

                                 SEQUENCE LISTING
                       

      <110> Tang, Y. Tom
        Wang, Jian-Rui
        Wang, Zhiwei
        Zhou, Ping
        Zhang, Jie
        Ghosh, Malabika
        Ren, Feiyan
        Asundi, Vinod
        Zhao, Qing A.
        Xue, Aidong J.
        Chen, Rui-hong
        Wehrman, Tom
        Ma, Yunqing
        Wang, Dunrui
        Weng, Gezhi


      <120> Novel Nucleic Acids and 
            Polypeptides



      <130> 819CIP/PCT

      <140> To Be Assigned
      <141> 2003-09-30
   
      <150> 60/416,186
      <151> 2002-10-02
      
      <150> PCT/US00/35017
      <151> 2000-12-22
  
      <150> PCT/US01/02623
      <151> 2001-01-25

      <150> PCT/US01/03800
      <151> 2001-02-05

      <150> PCT/US01/04927
      <151> 2001-02-26

      <150> PCT/US01/04941
      <151> 2001-03-05

      <150> PCT/US01/08631
      <151> 2001-03-30

      <150> PCT/US01/08656
      <151> 2001-04-18

      <150> 10/084,643
      <151> 2002-02-26


 
      <160> 2564

      <170> pt_FL_genes Version 6.0





      <210> 1
      <211> 1239
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(579)

      <400> 1
 cggcacgagc gactccccgc accactcagg gtcctgtgga cagctcacct agcggca        57                                                                 
 atg gct gca ggc tcc cgg acg tcc ctg ctc ctg gct ttt gcc ctg ctc      105
 Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu
   1               5                  10                  15

 tgc ctg ccc tgg ctt caa gag gct ggt gcc gtc caa acc gtt ccc tta      153
 Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu
              20                  25                  30

 tcc agg ctt ttt aaa gag gct atg ctc caa gcc cat cgc gca cac cag      201
 Ser Arg Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln
          35                  40                  45

 ctg gcc att gac acc tac cag gag ttt ata agc tct tgg gga atg ggt      249
 Leu Ala Ile Asp Thr Tyr Gln Glu Phe Ile Ser Ser Trp Gly Met Gly
      50                  55                  60

 gcg ggt cag ggg tgg caa gaa ggg gtg act ttc ccc cac tgg gga agt      297
 Ala Gly Gln Gly Trp Gln Glu Gly Val Thr Phe Pro His Trp Gly Ser
  65                  70                  75                  80

 aat ggg agg aga cta agg agc tca ggg ttg ttt tct gaa gcg aaa atg      345
 Asn Gly Arg Arg Leu Arg Ser Ser Gly Leu Phe Ser Glu Ala Lys Met
                  85                  90                  95

 cag gca gat gag cat agg ctg agc cag gtt ccc aga aga gta aca gtg      393
 Gln Ala Asp Glu His Arg Leu Ser Gln Val Pro Arg Arg Val Thr Val
             100                 105                 110

 gga gct ggt ctc cag cat aga aag cag tgg tcc ttc ttg gtg ggg ggt      441
 Gly Ala Gly Leu Gln His Arg Lys Gln Trp Ser Phe Leu Val Gly Gly
         115                 120                 125

 cct tcc cct agg aag aag cct ata tca caa agg aac aga agt att cat      489
 Pro Ser Pro Arg Lys Lys Pro Ile Ser Gln Arg Asn Arg Ser Ile His
     130                 135                 140

 tcc tgc atg act ccc aga cct cct tct gct tct cag act cta ttc cga      537
 Ser Cys Met Thr Pro Arg Pro Pro Ser Ala Ser Gln Thr Leu Phe Arg
 145                 150                 155                 160

 cat cct cca aca tgg agg aaa cgc agc aga aat cca act tag agctgct      586
 His Pro Pro Thr Trp Arg Lys Arg Ser Arg Asn Pro Thr 
                 165                 170

 ccacatctcc ctgctgctca tcgagtcgcg gctggagccc gtgcggttcc tcaggagtac    646

 cttcaccaac aacctggtgt atgacacctc ggacagcgat gactatcacc tcctaaagga    706

 cctagaggaa ggcatccaaa tgctgatggg ggtgagggtg gcaccagggg tccccaatcc    766

 tggaagccca ctggcttcga gggctggggg agagaaacac tgctgccctc ttttcagcag    826

 tcaggcgctg acccaagaga actcacctta ttcttcattt cccctcgtga atcctccagg    886

 cctttctcta caccctgaag gggaaggagg aaaatggata aatgagagag ggagggaaca    946

 gtgcccaagc gcttggtctc tccttctctt gcttcacttt gcagaggctg gaagacggca   1006

 gccacctgac tgggcagacc ctcaagcaga cctacagcaa gtttgacaca aactcgcaca   1066

 accatgacgc actgctcaag aactacgggc tgctccactg cttcaggaag gacatggaca   1126

 aggtcgagac attcctgcgc atggtgcagt gccgctctgt ggagggcagc tgtggcttct   1186

 aggggcccgc gtggcatcct gtgacccccc cccagccccc ccctcgccct gca          1239




      <210> 2
      <211> 1015
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(828)

      <400> 2
 cggcacgagc gactccccgc accactcagg gtcctgtgga cagctcacct agcggca        57                                                                 
 atg gct gca ggc tcc cgg acg tcc ctg ctc ctg gct ttt gcc ctg ctc      105
 Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu
   1               5                  10                  15

 tgc ctg ccc tgg ctt caa gag gct ggt gcc gtc caa acc gtt ccc tta      153
 Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu
              20                  25                  30

 tcc agg ctt ttt aaa gag gct atg ctc caa gcc cat cgc gca cac cag      201
 Ser Arg Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln
          35                  40                  45

 ctg gcc att gac acc tac cag gag ttt gaa gaa gcc tat atc aca aag      249
 Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Thr Lys
      50                  55                  60

 gaa cag aag tat tca ttc ctg cat gac tcc cag acc tcc ttc tgc ttc      297
 Glu Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe
  65                  70                  75                  80

 tca gac tct att ccg aca tcc tcc aac atg gag gaa acg cag cag aaa      345
 Ser Asp Ser Ile Pro Thr Ser Ser Asn Met Glu Glu Thr Gln Gln Lys
                  85                  90                  95

 tcc aac tta gag ctg ctc cac atc tcc ctg ctg ctc atc gag tcg cgg      393
 Ser Asn Leu Glu Leu Leu His Ile Ser Leu Leu Leu Ile Glu Ser Arg
             100                 105                 110

 ctg gag ccc gtg cgg ttc ctc agg agt acc ttc acc aac aac ctg gtg      441
 Leu Glu Pro Val Arg Phe Leu Arg Ser Thr Phe Thr Asn Asn Leu Val
         115                 120                 125

 tat gac acc tcg gac agc gat gac tat cac ctc cta aag gac cta gag      489
 Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu
     130                 135                 140

 gaa ggc atc caa atg ctg atg ggg gtg agg gtg gca cca ggg gtc ccc      537
 Glu Gly Ile Gln Met Leu Met Gly Val Arg Val Ala Pro Gly Val Pro
 145                 150                 155                 160

 aat cct gga agc cca ctg gct tcg agg gct ggg gga gag aaa cac tgc      585
 Asn Pro Gly Ser Pro Leu Ala Ser Arg Ala Gly Gly Glu Lys His Cys
                 165                 170                 175

 tgc cct ctt ttc agc agt cag gcg ctg acc caa gag aac tca cct tat      633
 Cys Pro Leu Phe Ser Ser Gln Ala Leu Thr Gln Glu Asn Ser Pro Tyr
             180                 185                 190

 tct tca ttt ccc ctc gtg aat cct cca ggc ctt tct cta cac cct gaa      681
 Ser Ser Phe Pro Leu Val Asn Pro Pro Gly Leu Ser Leu His Pro Glu
         195                 200                 205

 ggg gaa gga gga aaa tgg ata aat gag aga ggg agg gaa cag tgc cca      729
 Gly Glu Gly Gly Lys Trp Ile Asn Glu Arg Gly Arg Glu Gln Cys Pro
     210                 215                 220

 agc gct tgg tct ctc ctt ctc ttg ctt cac ttt gca gag gct gga aga      777
 Ser Ala Trp Ser Leu Leu Leu Leu Leu His Phe Ala Glu Ala Gly Arg
 225                 230                 235                 240

 cgg cag cca cct gac tgg gca gac cct caa gca gac cta cag caa gtt      825
 Arg Gln Pro Pro Asp Trp Ala Asp Pro Gln Ala Asp Leu Gln Gln Val
                 245                 250                 255

 tga caca aactcgcaca accatgacgc actgctcaag aactacgggc tgctccactg      882
 


 cttcaggaag gacatggaca aggtcgagac attcctgcgc atggtgcagt gccgctctgt    942

 ggagggcagc tgtggcttct aggggcccgc gtggcatcct gtgacccccc cccagccccc   1002

 ccctcgccct gca                                                      1015




      <210> 3
      <211> 997
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(120)

      <400> 3
 gagcatccca aggcccgact ccccgcacca ctcagggtcc tgtggacagc tcacctagcg     60

 gca  atg gct gca gga aga agc cta tat cac aaa gga aca gaa gta ttc     108
      Met Ala Ala Gly Arg Ser Leu Tyr His Lys Gly Thr Glu Val Phe
        1               5                  10                  15

 att cct gca tga ctc ccagacctcc ttctgcttct cagactctat tccgacatcc      163
 Ile Pro Ala 


 tccaacatgg aggaaacgca gcagaaatcc aacttagagc tgctccacat ctccctgctg    223

 ctcatcgagt cgcggctgga gcccgtgcgg ttcctcagga gtaccttcac caacaacctg    283

 gtgtatgaca cctcggacag cgatgactat cacctcctaa aggacctaga ggaaggcatc    343

 caaatgctga tggggaggct ggaagacggc agccacctga ctgggcagac cctcaagcag    403

 acctacagca agtttgacac aaactcgcac aaccatgacg cactgctcaa gaactacggg    463

 ctgctccact gcttcaggaa ggacatggac aaggtcgaga cattcctgcg catggtgcag    523

 tgccgctctg tggagggcag ctgtggcttc taggggcccg cgtggcatcc tgtgacccct    583

 ccccagtgcc tcttccctgg gccctgaagg tgccattccc aggggcccaa acaaaggcct    643

 ggtccttaat taacacttta acggttggaa tgggccagaa aaaagagaca gaacaaacaa    703

 cgaacaacac accatttgtg gcccggcacc gacgcccaca ggaacaagcg ttgcaagaac    763

 ccaccgcgat ggagtggacg cgcggagccg ccacagtgtg gtgaacggca gcaaggggtg    823

 ccaaaaggag gtgacccagg aggacaccgc ggcaggacac aaggggtggg atacccagca    883

 ctataaaaaa gccgcggggg acacacgaca gctgtgtaga acaccccagc agagcgtgcc    943

 cggaggccaa gaggacataa tcacagggag ccacagcgac ggcggataaa tacg          997




      <210> 4
      <211> 987
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(771)

      <400> 4
  atg gct cca ggc tcc cgg acg tcc ctg ctc ctg gct ttt gcc ctg ctc      48
  Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu
    1               5                  10                  15

 tgc ctg ccc tgg ctt caa gag gct ggt gcc gtc caa acc gtt ccg tta       96
 Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu
              20                  25                  30

 tcc agg ctt ttt gac cac gct atg ctc caa gcc cat cgc gcg cac cag      144
 Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln
          35                  40                  45

 ctg gcc att gac acc tac cag gag ttt gaa gaa acc tat atc cca aag      192
 Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys
      50                  55                  60

 gac cag aag tat tca ttc ctg cat gac tcc cag acc tcc ttc tgc ttc      240
 Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe
  65                  70                  75                  80

 tca gac tct att ccg aca ccc tcc aac atg gag gaa acg caa cag aaa      288
 Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys
                  85                  90                  95

 tcc aat cta gag ctg ctc cgc atc tcc ctg ctg ctc atc gag tcg tgg      336
 Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp
             100                 105                 110

 ctg gag ccc gtg cgg ttc ctc agg agt atg ttc gcc aac aac ctg gtg      384
 Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val
         115                 120                 125

 tat gac acc tcg gac agc gat gac tat cac ctc cta aag gac cta gag      432
 Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu
     130                 135                 140

 gaa ggc atc caa acg ctg atg ggg gtg agg gtg gcg cca ggg gtc acc      480
 Glu Gly Ile Gln Thr Leu Met Gly Val Arg Val Ala Pro Gly Val Thr
 145                 150                 155                 160

 aat cct gga acc cca ctg gct tcg agg gct ggg gga gag aaa tac tgc      528
 Asn Pro Gly Thr Pro Leu Ala Ser Arg Ala Gly Gly Glu Lys Tyr Cys
                 165                 170                 175

 tgc cct ctt ttt agc agt aag gcg ctg acc caa gag aac tca cct tat      576
 Cys Pro Leu Phe Ser Ser Lys Ala Leu Thr Gln Glu Asn Ser Pro Tyr
             180                 185                 190

 tct tca ttt cgc ctg gtg aat cct cca ggc ctt tct cta cac cct gaa      624
 Ser Ser Phe Arg Leu Val Asn Pro Pro Gly Leu Ser Leu His Pro Glu
         195                 200                 205

 ggg gag gga gga aaa tgg ata aat gag aga ggg agg gaa cag tgc cca      672
 Gly Glu Gly Gly Lys Trp Ile Asn Glu Arg Gly Arg Glu Gln Cys Pro
     210                 215                 220

 agc gct tgg cct ctc ctt ctc ttc ctt cac ttt gca gag gct gga aga      720
 Ser Ala Trp Pro Leu Leu Leu Phe Leu His Phe Ala Glu Ala Gly Arg
 225                 230                 235                 240

 cgg cag ccg ccg gac tgg gca gat cct caa gca gac cta cag caa gtt      768
 Arg Gln Pro Pro Asp Trp Ala Asp Pro Gln Ala Asp Leu Gln Gln Val
                 245                 250                 255

 tga caca aactcgcaca accatgacgc actgctcaag aactacgggc tgctctactg      825
 


 cttcaggaag gacatggaca aggtcgagac attcctgcgc atggtgcagt gccgctctgt    885

 ggagggcagc tgtggcttct aggtgcccga gtagcatcct gtgacccctc cccagtgcct    945

 ctcctggccc tgaaggtgcc actccagtgc ccaccagcct tg                       987




      <210> 5
      <211> 1479
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (150)..(1352)

      <400> 5
 taagaaagga gtagctgtaa tctgaagcct gctggacgct ggattagaag gcagcaaaaa     60

 aagctctgtg ctggctggag ccccctcagt gtgcaggctt agagggacta ggctgggtgt    120

 ggagctgcag cgtatccaca ggccccagg  atg cag gcc ctg gtg cta ctc ctc     173
                                  Met Gln Ala Leu Val Leu Leu Leu
                                    1               5

 tgc att gga gcc ctc ctc ggg cac agc agc tgc cag aac cct gcc agc      221
 Cys Ile Gly Ala Leu Leu Gly His Ser Ser Cys Gln Asn Pro Ala Ser
      10                  15                  20

 ccc ccg gag gag ggc tcc cca gac ccc gac agc aca ggg gcg ctg gtg      269
 Pro Pro Glu Glu Gly Ser Pro Asp Pro Asp Ser Thr Gly Ala Leu Val
  25                  30                  35                  40

 gag gag gag gat cct ttc ttc aaa gtc ccc gtg aac aag ctg gca gcg      317
 Glu Glu Glu Asp Pro Phe Phe Lys Val Pro Val Asn Lys Leu Ala Ala
                  45                  50                  55

 gct gtc tcc aac ttc ggc tat gac ctg tac cgg gtg cga tcc agc acg      365
 Ala Val Ser Asn Phe Gly Tyr Asp Leu Tyr Arg Val Arg Ser Ser Thr
              60                  65                  70

 agc ccc acg acc aac gtg ctc ctg tct cct ctc agt gtg gcc acg gcc      413
 Ser Pro Thr Thr Asn Val Leu Leu Ser Pro Leu Ser Val Ala Thr Ala
          75                  80                  85

 ctc tcg gcc ctc tcg ctg gga gcg gag cag cga aca gaa tcc atc att      461
 Leu Ser Ala Leu Ser Leu Gly Ala Glu Gln Arg Thr Glu Ser Ile Ile
      90                  95                 100

 cac cgg gct ctc tac tat gac ttg atc agc agc cca gac atc cat ggt      509
 His Arg Ala Leu Tyr Tyr Asp Leu Ile Ser Ser Pro Asp Ile His Gly
 105                 110                 115                 120

 acc tat aag gag ctc ctt gac acg gtc acc gcc ccc cag aag aac ctc      557
 Thr Tyr Lys Glu Leu Leu Asp Thr Val Thr Ala Pro Gln Lys Asn Leu
                 125                 130                 135

 aag agt gcc tcc cgg atc gtc ttt gag aag aag ctg cgc ata aaa tcc      605
 Lys Ser Ala Ser Arg Ile Val Phe Glu Lys Lys Leu Arg Ile Lys Ser
             140                 145                 150

 agc ttt gtg gca cct ctg gtg caa gag atc aac aac tgg gtg cag gcg      653
 Ser Phe Val Ala Pro Leu Val Gln Glu Ile Asn Asn Trp Val Gln Ala
         155                 160                 165

 cag atg aaa ggg aag ctc gcc agg tcc aca aag gaa att ccc gat gag      701
 Gln Met Lys Gly Lys Leu Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu
     170                 175                 180

 atc agc att ctc ctt ctc ggt gtg gcg cac ttc aag ggg cag tgg gta      749
 Ile Ser Ile Leu Leu Leu Gly Val Ala His Phe Lys Gly Gln Trp Val
 185                 190                 195                 200

 aca aag ttt gac tcc aga aag act tcc ctc gag gat ttc tac ttg gat      797
 Thr Lys Phe Asp Ser Arg Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp
                 205                 210                 215

 gaa gag agg acc gtg agg gtc ccc atg atg tcg gac cct aag gct gtt      845
 Glu Glu Arg Thr Val Arg Val Pro Met Met Ser Asp Pro Lys Ala Val
             220                 225                 230

 tta cgc tat ggc ttg gat tca gat ctc agc tgc aag att gcc cag ctg      893
 Leu Arg Tyr Gly Leu Asp Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu
         235                 240                 245

 ccc ttg acc gga agc atg agt atc atc ttc ttc ctg ccc ctg aaa gtg      941
 Pro Leu Thr Gly Ser Met Ser Ile Ile Phe Phe Leu Pro Leu Lys Val
     250                 255                 260

 acc cag aat ttg acc ttg ata gag gag agc ctc acc tcc gag ttc att      989
 Thr Gln Asn Leu Thr Leu Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile
 265                 270                 275                 280

 cat gac ata gac cga gaa ctg aag acc gtg cag gcg gtc ctc act gtc     1037
 His Asp Ile Asp Arg Glu Leu Lys Thr Val Gln Ala Val Leu Thr Val
                 285                 290                 295

 ccc aag ctg aag ctg agt tac gaa ggc gaa gtc acc aag tcc ctg cag     1085
 Pro Lys Leu Lys Leu Ser Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln
             300                 305                 310

 gag atg aag ctg caa tcc ttg ttt gat tca cca gac ttt agc aag atc     1133
 Glu Met Lys Leu Gln Ser Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile
         315                 320                 325

 aca ggc aaa ccc atc aag ctg act cag gtg gaa cac cgg gct ggc ttt     1181
 Thr Gly Lys Pro Ile Lys Leu Thr Gln Val Glu His Arg Ala Gly Phe
     330                 335                 340

 gag tgg aac gag gat ggg gcg gga acc acc ccc agc cca ggg ctg cag     1229
 Glu Trp Asn Glu Asp Gly Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln
 345                 350                 355                 360

 cct gcc cac ctc acc ttc ccg ctg gac tat cac ctt aac cag cct ttc     1277
 Pro Ala His Leu Thr Phe Pro Leu Asp Tyr His Leu Asn Gln Pro Phe
                 365                 370                 375

 atc ttc gta ctg agg gac aca gac aca ggg gcc ctt ctc ttc att ggc     1325
 Ile Phe Val Leu Arg Asp Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly
             380                 385                 390

 aag att ctg gac ccc agg ggc ccc taa tatcc cagtttaata ttccaatacc     1377
 Lys Ile Leu Asp Pro Arg Gly Pro 
         395                 400

 ctagaagaaa acccgaggga cagcagattc cacaggacac gaaggctgcc cctgtaaggt   1437

 ttcaatgcat acaataaaag agctttatcc ctaaaaaaaa aa                      1479




      <210> 6
      <211> 1730
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (381)..(1091)

      <400> 6
 gaaacaagcc agtgcaaggg gagcaaaaga gaaaaggagc caggctgggc ttcctgatcc     60

 cacagcatcg cagagctcgg gaggcacagc tcacagacac aggaaacaca ggactgctat    120

 tctgctcccc tgcccacggt gatctggtgc cagctggtgg aacagtgggt gatggcgtcc    180

 ctgctgcaag accagctgac cactgatcag gacttgctgc tgatgcagga aggcatgccg    240

 atgcgcaagt ctcaatctct gatgtggaga caatacgtaa tggccatgat tccgagttgc    300

 tgcgtagcct ggcagaggag ctccccctgg agcagggctt caccattgtc ttccatggcc    360

 gccgctccaa cctggacctg    atg gcc aac agt gtt gag gag gcc cag ata     410
                          Met Ala Asn Ser Val Glu Glu Ala Gln Ile
                            1               5                  10

 tgg atg cga ggg ctc cag ctg ttg gtg gat ctt gtc acc agc atg gac      458
 Trp Met Arg Gly Leu Gln Leu Leu Val Asp Leu Val Thr Ser Met Asp
                  15                  20                  25

 cat cag gag cgc ctg gac caa tgg ctg agc gat tgg ttt caa cgt gga      506
 His Gln Glu Arg Leu Asp Gln Trp Leu Ser Asp Trp Phe Gln Arg Gly
              30                  35                  40

 gac aaa aat cag gat ggt aag atg agt ttc caa gaa gtt cag cgg tta      554
 Asp Lys Asn Gln Asp Gly Lys Met Ser Phe Gln Glu Val Gln Arg Leu
          45                  50                  55

 ttg cac cta atg aat gtg gaa atg gac caa gaa tat gcc ttc agt ctt      602
 Leu His Leu Met Asn Val Glu Met Asp Gln Glu Tyr Ala Phe Ser Leu
      60                  65                  70

 ttt cag gca gca gac acg tcc cag tct gga acc ctg gaa gga gaa gaa      650
 Phe Gln Ala Ala Asp Thr Ser Gln Ser Gly Thr Leu Glu Gly Glu Glu
  75                  80                  85                  90

 ttc gta cag ttc tat aag gca ttg act aaa cgt gct gag gtg cag gaa      698
 Phe Val Gln Phe Tyr Lys Ala Leu Thr Lys Arg Ala Glu Val Gln Glu
                  95                 100                 105

 ctg ttt gaa agt ttt tca gct gat ggg cag aag ctg act ctg ctg gaa      746
 Leu Phe Glu Ser Phe Ser Ala Asp Gly Gln Lys Leu Thr Leu Leu Glu
             110                 115                 120

 ttt ttg gat ttc ctc caa gag gag cag aag gag aga gac tgc acc tct      794
 Phe Leu Asp Phe Leu Gln Glu Glu Gln Lys Glu Arg Asp Cys Thr Ser
         125                 130                 135

 gag ctt gct ctg gaa ctc att gac cgc tat gaa cct tca gac agt ggc      842
 Glu Leu Ala Leu Glu Leu Ile Asp Arg Tyr Glu Pro Ser Asp Ser Gly
     140                 145                 150

 aaa ctg cgg cat gtg ccg agt atg gat ggc ttc ctc agc tac ctc tgc      890
 Lys Leu Arg His Val Pro Ser Met Asp Gly Phe Leu Ser Tyr Leu Cys
 155                 160                 165                 170

 tct aag gat gga gac atc ttc aac cca gcc tgc ctc ccc atc tat cag      938
 Ser Lys Asp Gly Asp Ile Phe Asn Pro Ala Cys Leu Pro Ile Tyr Gln
                 175                 180                 185

 gat atg act caa ccc ctg aac cac tac ttc atc tgc tct tct cat aac      986
 Asp Met Thr Gln Pro Leu Asn His Tyr Phe Ile Cys Ser Ser His Asn
             190                 195                 200

 acc tac cta gtg ggg gac cag ctt tgc ggc cag agc agc gtc gag gga     1034
 Thr Tyr Leu Val Gly Asp Gln Leu Cys Gly Gln Ser Ser Val Glu Gly
         205                 210                 215

 tat ata cgg tgc agt ggt ggt aga gaa ggg gtc caa ctc atg aga ggg     1082
 Tyr Ile Arg Cys Ser Gly Gly Arg Glu Gly Val Gln Leu Met Arg Gly
     220                 225                 230

 acc atg tag aaaagtg aggggagctg tcagtgtcta acagattggg acagtgttgt     1138
 Thr Met 
 235

 gggggtttag gggctgagga gccctggata ccagagacac ttggaggaga tattgaagac   1198

 tggtgggaga atggtaatga aaccctatgg gtcaatggaa cttctctttc acaagctatg   1258

 aaactctcct ggaactcaga ggccctgaca gatttatatt taacaaatta ataaacagat   1318

 tgttaaatgg aaggcaatag agaataggag ttaaaaatat aggttctgga gtcagaccat   1378

 ctgaaattat atcctagctc cttcacttgg tactctgggg ctaagtattt aacgtctata   1438

 cctcagtctc cccatctgtg aaacagggat ggtaacagtg cctattctgt ctgggttgtt   1498

 gtgaagagat aattcatatg tcaatagcta ataagcagtt ctgattttat tgtgactaat   1558

 catggattag attgaatagt caagatatct ttctattacc agcctgagca gcataatgat   1618

 acctcatctc tacaaaaaat aaacaaaaag tagccacgtg tggtggcaca tgcgtgtagt   1678

 tccagtacca gggaggctga ggtgagaggt tcacctgagt ccagaggtcg ag           1730




      <210> 7
      <211> 2831
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(2109)

      <400> 7
 cccacgcgtc cgcccacgcg tccgcccacg cgtccgctcg gtgaacggcg cgcggggtct     60

 ctcctgagtg cgagctacgg gaccttcgcc     atg ccg ggg atg gta ctc ttc     111
                                      Met Pro Gly Met Val Leu Phe
                                        1               5

 ggc cgg cgc tgg gcc atc gcc agc gac gac ttg gtc ttc cca ggg ttc      159
 Gly Arg Arg Trp Ala Ile Ala Ser Asp Asp Leu Val Phe Pro Gly Phe
          10                  15                  20

 ttc gag ctg gtc gtg cga gtg ctg tgg tgg att ggc att ctg acg ttg      207
 Phe Glu Leu Val Val Arg Val Leu Trp Trp Ile Gly Ile Leu Thr Leu
      25                  30                  35

 tat ctc atg cac aga gga aag ctg gac tgt gct ggt gga gcc ttg ctc      255
 Tyr Leu Met His Arg Gly Lys Leu Asp Cys Ala Gly Gly Ala Leu Leu
  40                  45                  50                  55

 agc agt tac ttg atc gtc ctc atg att ctc ctg gca gtt gtc ata tgt      303
 Ser Ser Tyr Leu Ile Val Leu Met Ile Leu Leu Ala Val Val Ile Cys
                  60                  65                  70

 act gtg tca gcc atc atg tgt gtc agc atg aga gga acg att tgt aac      351
 Thr Val Ser Ala Ile Met Cys Val Ser Met Arg Gly Thr Ile Cys Asn
              75                  80                  85

 cct gga ccg cgg aag tct atg tct aag ctg ctt tac atc cgc ctg gcg      399
 Pro Gly Pro Arg Lys Ser Met Ser Lys Leu Leu Tyr Ile Arg Leu Ala
          90                  95                 100

 ctg ttt ttt cca gag atg gtc tgg gcc tct ctg ggg gct gcc tgg gtg      447
 Leu Phe Phe Pro Glu Met Val Trp Ala Ser Leu Gly Ala Ala Trp Val
     105                 110                 115

 gca gat ggt gtt cag tgc gac agg aca gtt gta aac ggc atc atc gca      495
 Ala Asp Gly Val Gln Cys Asp Arg Thr Val Val Asn Gly Ile Ile Ala
 120                 125                 130                 135

 acc gtc gtg gtc agt tgg atc atc atc gct gcc aca gtg gtt tcc att      543
 Thr Val Val Val Ser Trp Ile Ile Ile Ala Ala Thr Val Val Ser Ile
                 140                 145                 150

 atc att gtc ttt gac cct ctt ggg ggg aaa atg gct cca tat tcc tct      591
 Ile Ile Val Phe Asp Pro Leu Gly Gly Lys Met Ala Pro Tyr Ser Ser
             155                 160                 165

 gcc ggc ccc agc cac ctg gat agt cat gat tca agc cag tta ctt aat      639
 Ala Gly Pro Ser His Leu Asp Ser His Asp Ser Ser Gln Leu Leu Asn
         170                 175                 180

 ggc ctc aag aca gca gct aca agc gtg tgg gaa acc aga atc aag ctc      687
 Gly Leu Lys Thr Ala Ala Thr Ser Val Trp Glu Thr Arg Ile Lys Leu
     185                 190                 195

 ttg tgc tgt tgc att ggg aaa gac gac cat act cgg gtt gct ttt tcg      735
 Leu Cys Cys Cys Ile Gly Lys Asp Asp His Thr Arg Val Ala Phe Ser
 200                 205                 210                 215

 agt acg gca gag ctt ttc tca acc tac ttt tca gac aca gat ctg gtg      783
 Ser Thr Ala Glu Leu Phe Ser Thr Tyr Phe Ser Asp Thr Asp Leu Val
                 220                 225                 230

 ccc agc gac att gcg gcg ggc ctc gcc ctg ctt cat cag caa cag gac      831
 Pro Ser Asp Ile Ala Ala Gly Leu Ala Leu Leu His Gln Gln Gln Asp
             235                 240                 245

 aat atc agg aac aac caa gag cct gcc cag gtg gtc tgc cat gcc cca      879
 Asn Ile Arg Asn Asn Gln Glu Pro Ala Gln Val Val Cys His Ala Pro
         250                 255                 260

 ggg agc tcc cag gaa gct gat ctg gat gca gaa tta gaa aac tgc cat      927
 Gly Ser Ser Gln Glu Ala Asp Leu Asp Ala Glu Leu Glu Asn Cys His
     265                 270                 275

 cat tac atg cag ttt gca gca gcg gcc tat ggg tgg ccc ctc tac atc      975
 His Tyr Met Gln Phe Ala Ala Ala Ala Tyr Gly Trp Pro Leu Tyr Ile
 280                 285                 290                 295

 tac aga aac ccc ctc acg ggg ctg tgc agg att ggt ggt gac tgc tgc     1023
 Tyr Arg Asn Pro Leu Thr Gly Leu Cys Arg Ile Gly Gly Asp Cys Cys
                 300                 305                 310

 aga agc aga acc aca gac tat gac ttg gtc gga ggc gat cag ctc aac     1071
 Arg Ser Arg Thr Thr Asp Tyr Asp Leu Val Gly Gly Asp Gln Leu Asn
             315                 320                 325

 tgt cac ttc ggc tcc atc ctg cac acc aca ggg ctg cag tac agg gac     1119
 Cys His Phe Gly Ser Ile Leu His Thr Thr Gly Leu Gln Tyr Arg Asp
         330                 335                 340

 ttc atc cac gtc agc ttc cat gac aag gtt tac gag ctg ccg ttt tta     1167
 Phe Ile His Val Ser Phe His Asp Lys Val Tyr Glu Leu Pro Phe Leu
     345                 350                 355

 gtg gct ctg gat cac agg aaa gag tct gtt gtg gtc gct gtg agg ggg     1215
 Val Ala Leu Asp His Arg Lys Glu Ser Val Val Val Ala Val Arg Gly
 360                 365                 370                 375

 acc atg tct ctg cag gat gtc ctt acg gac ctg tca gcg gag agt gag     1263
 Thr Met Ser Leu Gln Asp Val Leu Thr Asp Leu Ser Ala Glu Ser Glu
                 380                 385                 390

 gtg ctg gac gtg gag tgt gag gtg cag gac cgc ctg gca cac aag ggt     1311
 Val Leu Asp Val Glu Cys Glu Val Gln Asp Arg Leu Ala His Lys Gly
             395                 400                 405

 att tct caa gct gcc aga tac gtt tac caa cga ctc atc aac gac ggg     1359
 Ile Ser Gln Ala Ala Arg Tyr Val Tyr Gln Arg Leu Ile Asn Asp Gly
         410                 415                 420

 att ttg agc caa gcc ttc agc att gct cct gag tac cgg ctg gtc ata     1407
 Ile Leu Ser Gln Ala Phe Ser Ile Ala Pro Glu Tyr Arg Leu Val Ile
     425                 430                 435

 gtg ggc cac agc ctc ggg gga ggg gcg gcc gcc ctg ctg gcc acc atg     1455
 Val Gly His Ser Leu Gly Gly Gly Ala Ala Ala Leu Leu Ala Thr Met
 440                 445                 450                 455

 ctc aga gcc gcc tac ccg cag gtc agg tgc tac gcc ttc tcc cca ccc     1503
 Leu Arg Ala Ala Tyr Pro Gln Val Arg Cys Tyr Ala Phe Ser Pro Pro
                 460                 465                 470

 cgg ggg ctg tgg agc aaa gct ctg cag gaa tat tct cag agc ttc atc     1551
 Arg Gly Leu Trp Ser Lys Ala Leu Gln Glu Tyr Ser Gln Ser Phe Ile
             475                 480                 485

 gtg tca ctc gtc ctg ggg aag gat gtg att ccc agg ctc agt gtg acc     1599
 Val Ser Leu Val Leu Gly Lys Asp Val Ile Pro Arg Leu Ser Val Thr
         490                 495                 500

 aac ttg gaa gat ctg aag aga aga atc ttg cga gtg gtc gcg cac tgc     1647
 Asn Leu Glu Asp Leu Lys Arg Arg Ile Leu Arg Val Val Ala His Cys
     505                 510                 515

 aat aaa ccc aag tac aag atc ttg ctg cac ggt ttg tgg tac gaa ctg     1695
 Asn Lys Pro Lys Tyr Lys Ile Leu Leu His Gly Leu Trp Tyr Glu Leu
 520                 525                 530                 535

 ttt gga gga aac ccc aac aac ttg ccc acg gag ctg gac ggg ggc gac     1743
 Phe Gly Gly Asn Pro Asn Asn Leu Pro Thr Glu Leu Asp Gly Gly Asp
                 540                 545                 550

 cag gaa gtc ctg aca cag cct ctt ctg ggg gag cag agc cta ctg acg     1791
 Gln Glu Val Leu Thr Gln Pro Leu Leu Gly Glu Gln Ser Leu Leu Thr
             555                 560                 565

 cgc tgg tcc ccg gcc tac agc ttc tcc agc gac tcc cca ctg gac tct     1839
 Arg Trp Ser Pro Ala Tyr Ser Phe Ser Ser Asp Ser Pro Leu Asp Ser
         570                 575                 580

 tct ccc aag tac ccc cct ctc tac cct ccc ggc agg atc atc cac ctg     1887
 Ser Pro Lys Tyr Pro Pro Leu Tyr Pro Pro Gly Arg Ile Ile His Leu
     585                 590                 595

 cag gag gag ggc gcc tcg ggg cgg ttt ggc tgc tgc tct gct gct cac     1935
 Gln Glu Glu Gly Ala Ser Gly Arg Phe Gly Cys Cys Ser Ala Ala His
 600                 605                 610                 615

 tat agc gcc aag tgg tca cac gaa gcg gaa ttc agc aaa ata ctc ata     1983
 Tyr Ser Ala Lys Trp Ser His Glu Ala Glu Phe Ser Lys Ile Leu Ile
                 620                 625                 630

 ggt ccg aag atg ctc acc gac cac atg cca gac atc ctg atg cgg gcc     2031
 Gly Pro Lys Met Leu Thr Asp His Met Pro Asp Ile Leu Met Arg Ala
             635                 640                 645

 ttg gac agc gtg gtc tcc gac aga gcg gcc tgc gtc tcc tgt cca gca     2079
 Leu Asp Ser Val Val Ser Asp Arg Ala Ala Cys Val Ser Cys Pro Ala
         650                 655                 660

 caa ggg gtc tcc agt gtg gac gtg gcc tga c cagggccact ggaaactgtc     2130
 Gln Gly Val Ser Ser Val Asp Val Ala 
     665                 670

 ccaggaacga tggactcacg cttttgtcct taaactgact taccatccga ggagttccca   2190

 tgacgccaaa acagcgaatg tccatcaaca ggaatcggat gggaacagaa ttccatggtc   2250

 tcaatgactt aagtttatgg gaagtcattg tggccataat ggtagcagaa gtagtgagca   2310

 cgctcaggtg ataggacgac tcctgagacc cagcgaccgt ggagacagcc tcgggaagcc   2370

 ctggcccgtg gatggatccc ttggctgtct gaggactgct ccagaagtgc gggaatccag   2430

 ggcccaccca gaagaccgtg aacagttcct tagcctccca ccccccaagg cagctctttt   2490

 catccaactc agtttacagg cgtggtttgt ttttcaaact gggcttcctg gatgtacaaa   2550

 tggaactgtg gtgagggtgc gggctggggt tttctcctgg gcgtcaccaa gggcagccct   2610

 gggctctggc tggggatgaa gacgaaaccc gatcgggaaa gtaagtggag cccccggccc   2670

 cgccgagcca cagcccccca actgcctatt cccactgccc agttgtttgt ccacatcagg   2730

 agttgctgat tgaattcttg ctactcttct ggctctgggg tcggccagtg gattcaggag   2790

 ttgaaacaat aaagcgcgcg tcacgatagt gaaaaaaaaa a                       2831




      <210> 8
      <211> 4401
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(2279)

      <400> 8
 ccgggtcgac gatttcgtcg ctgctggggg gcgacgtgtc ggcccccgaa ggcacgaag      59                                                                 
 atg ggc gcc gtg ccc tgc cgc cgg gct ctt ctg ctt tgc aac ggg atg      107
 Met Gly Ala Val Pro Cys Arg Arg Ala Leu Leu Leu Cys Asn Gly Met
   1               5                  10                  15

 agg tac aaa ctg ctg cag gag ggc gac att cag gtc tgt gtc atc cgg      155
 Arg Tyr Lys Leu Leu Gln Glu Gly Asp Ile Gln Val Cys Val Ile Arg
              20                  25                  30

 cac ccg cgg acc ttt ctc agc aag atc ctc acc tcg aaa ttc ctg agg      203
 His Pro Arg Thr Phe Leu Ser Lys Ile Leu Thr Ser Lys Phe Leu Arg
          35                  40                  45

 cgc tgg gag ccg cac cac cta acg ctg gcc gac aac agc ctg gcg tcc      251
 Arg Trp Glu Pro His His Leu Thr Leu Ala Asp Asn Ser Leu Ala Ser
      50                  55                  60

 gcc acg cca act ggg tac atg gaa aac tca gtc tcc tac agc gca att      299
 Ala Thr Pro Thr Gly Tyr Met Glu Asn Ser Val Ser Tyr Ser Ala Ile
  65                  70                  75                  80

 gaa gac gtt cag ctg ctg tcc tgg gag aat gcc ccg aag tac tgt tta      347
 Glu Asp Val Gln Leu Leu Ser Trp Glu Asn Ala Pro Lys Tyr Cys Leu
                  85                  90                  95

 cag ctc acg att cct ggg gga act gtc tta ctg cag gct gcc aat agc      395
 Gln Leu Thr Ile Pro Gly Gly Thr Val Leu Leu Gln Ala Ala Asn Ser
             100                 105                 110

 tac ctg cga gac cag tgg ttc cat tct ctg caa tgg aag aaa aag att      443
 Tyr Leu Arg Asp Gln Trp Phe His Ser Leu Gln Trp Lys Lys Lys Ile
         115                 120                 125

 tac aaa tat aag aaa gtg ctg agt aac cca agc cgc tgg gaa gtt gtc      491
 Tyr Lys Tyr Lys Lys Val Leu Ser Asn Pro Ser Arg Trp Glu Val Val
     130                 135                 140

 ttg aaa gag atc cgg acc ctg gtg gac atg gcc ctg aca tcc ccc ctg      539
 Leu Lys Glu Ile Arg Thr Leu Val Asp Met Ala Leu Thr Ser Pro Leu
 145                 150                 155                 160

 cag gat gac tcc atc aac cag gcc cca ctg gaa atc gtc tcg aaa ctg      587
 Gln Asp Asp Ser Ile Asn Gln Ala Pro Leu Glu Ile Val Ser Lys Leu
                 165                 170                 175

 ctc tca gag aac aca aac ttg acc acc cag gag cat gaa aac atc att      635
 Leu Ser Glu Asn Thr Asn Leu Thr Thr Gln Glu His Glu Asn Ile Ile
             180                 185                 190

 gtg gca atc gct cct ttg ctg gaa aac aac cac cca cca cca gat ctc      683
 Val Ala Ile Ala Pro Leu Leu Glu Asn Asn His Pro Pro Pro Asp Leu
         195                 200                 205

 tgt gaa ttc ttt tgc aag cac tgc aga gag cgg ccc cgg tcc atg gtg      731
 Cys Glu Phe Phe Cys Lys His Cys Arg Glu Arg Pro Arg Ser Met Val
     210                 215                 220

 gtc atc gag gtg ttc acc ccc gtg gtg cag cga atc ctc aag cat aac      779
 Val Ile Glu Val Phe Thr Pro Val Val Gln Arg Ile Leu Lys His Asn
 225                 230                 235                 240

 atg gac ttt ggg aag tgc ccg cga ctg agg ctg ttt act cag gag tac      827
 Met Asp Phe Gly Lys Cys Pro Arg Leu Arg Leu Phe Thr Gln Glu Tyr
                 245                 250                 255

 atc ctt gcc ttg aac gag ctc aac gcg ggg atg gaa gtg gtg aag aag      875
 Ile Leu Ala Leu Asn Glu Leu Asn Ala Gly Met Glu Val Val Lys Lys
             260                 265                 270

 ttc att cag agc atg cac ggc ccc aca ggg cac tgc ccc cac ccc cgg      923
 Phe Ile Gln Ser Met His Gly Pro Thr Gly His Cys Pro His Pro Arg
         275                 280                 285

 gtc ctg ccc aac ctg gtg gcc gtg tgc ctg gct gcc atc tac tcc tgc      971
 Val Leu Pro Asn Leu Val Ala Val Cys Leu Ala Ala Ile Tyr Ser Cys
     290                 295                 300

 tat gaa gag ttc atc aac agc cgc gac aat tcc cca agc ctg aag gaa     1019
 Tyr Glu Glu Phe Ile Asn Ser Arg Asp Asn Ser Pro Ser Leu Lys Glu
 305                 310                 315                 320

 atc cgg aac ggc tgc cag cag ccg tgc gac cgg aag ccc act tta cct     1067
 Ile Arg Asn Gly Cys Gln Gln Pro Cys Asp Arg Lys Pro Thr Leu Pro
                 325                 330                 335

 ctg cgc ctt ctg cac ccc agc ccg gac ctg gtg tct cag gaa gcc acg     1115
 Leu Arg Leu Leu His Pro Ser Pro Asp Leu Val Ser Gln Glu Ala Thr
             340                 345                 350

 ctg tct gag gcc cgg ctc aag tcg gtg gtc gtg gcc tcc agt gag atc     1163
 Leu Ser Glu Ala Arg Leu Lys Ser Val Val Val Ala Ser Ser Glu Ile
         355                 360                 365

 cac gtg gag gtg gaa cgc acc agc act gcc aag ccg gcg ctg acg gcc     1211
 His Val Glu Val Glu Arg Thr Ser Thr Ala Lys Pro Ala Leu Thr Ala
     370                 375                 380

 agc gca ggc aac gac agc gag ccc aac ctc atc gac tgc ctc atg gtc     1259
 Ser Ala Gly Asn Asp Ser Glu Pro Asn Leu Ile Asp Cys Leu Met Val
 385                 390                 395                 400

 agc ccc gcc tgc agc acc atg agc atc gag ctg ggc ccc cag gcc gac     1307
 Ser Pro Ala Cys Ser Thr Met Ser Ile Glu Leu Gly Pro Gln Ala Asp
                 405                 410                 415

 cgc acg ctc ggc tgc tac gtg gaa atc ctc aag ctg ctg tca gac tat     1355
 Arg Thr Leu Gly Cys Tyr Val Glu Ile Leu Lys Leu Leu Ser Asp Tyr
             420                 425                 430

 gat gac tgg aga ccg tct ctg gcc agt ttg ctt caa ccc att cca ttc     1403
 Asp Asp Trp Arg Pro Ser Leu Ala Ser Leu Leu Gln Pro Ile Pro Phe
         435                 440                 445

 ccc aaa gaa gct ctc gca cat gag aag ttc acc aag gaa ctg aag tac     1451
 Pro Lys Glu Ala Leu Ala His Glu Lys Phe Thr Lys Glu Leu Lys Tyr
     450                 455                 460

 gtg att cag agg ttc gcc gaa gac ccc agg caa gag gtc cac tca tgc     1499
 Val Ile Gln Arg Phe Ala Glu Asp Pro Arg Gln Glu Val His Ser Cys
 465                 470                 475                 480

 ctg ctg agc gtg cgg gcc ggc aaa gat ggc tgg ttc cag ctc tac agc     1547
 Leu Leu Ser Val Arg Ala Gly Lys Asp Gly Trp Phe Gln Leu Tyr Ser
                 485                 490                 495

 ccc gga ggg gtg gcc tgc gac gat gac ggg gag ctg ttc gcc agc atg     1595
 Pro Gly Gly Val Ala Cys Asp Asp Asp Gly Glu Leu Phe Ala Ser Met
             500                 505                 510

 gtg cac atc ctc atg ggc tcc tgt tac aag acc aaa aaa ttc ctg ctc     1643
 Val His Ile Leu Met Gly Ser Cys Tyr Lys Thr Lys Lys Phe Leu Leu
         515                 520                 525

 tcc ctg gca gaa aac aag ctg ggt ccc tgc atg ctc ctg gca ctg agg     1691
 Ser Leu Ala Glu Asn Lys Leu Gly Pro Cys Met Leu Leu Ala Leu Arg
     530                 535                 540

 ggg aac cag acc atg gtg gag atc ctg tgc ttg atg ctg gaa tac aac     1739
 Gly Asn Gln Thr Met Val Glu Ile Leu Cys Leu Met Leu Glu Tyr Asn
 545                 550                 555                 560

 atc atc gac aac aac gac acc caa ctg cag atc atc tca acc ctg gag     1787
 Ile Ile Asp Asn Asn Asp Thr Gln Leu Gln Ile Ile Ser Thr Leu Glu
                 565                 570                 575

 agc aca gac gtg ggg aag cgc atg tac gag cag ctg tgt gac cgg cag     1835
 Ser Thr Asp Val Gly Lys Arg Met Tyr Glu Gln Leu Cys Asp Arg Gln
             580                 585                 590

 cgg gag ctg aag gag ctg caa agg aaa ggc ggg ccc acc agg cta aca     1883
 Arg Glu Leu Lys Glu Leu Gln Arg Lys Gly Gly Pro Thr Arg Leu Thr
         595                 600                 605

 ctg ccc tcc aag tcc aca gac gct gac ttg gct cgt ttg ctg agc tcc     1931
 Leu Pro Ser Lys Ser Thr Asp Ala Asp Leu Ala Arg Leu Leu Ser Ser
     610                 615                 620

 ggc tcc ttc gga aac ctg gag aac ctc agt ttg gcc ttc acc aat gta     1979
 Gly Ser Phe Gly Asn Leu Glu Asn Leu Ser Leu Ala Phe Thr Asn Val
 625                 630                 635                 640

 acc agt gcc tgc gcc gag cac ctc atc aaa ctg cct tcg ctc aag cag     2027
 Thr Ser Ala Cys Ala Glu His Leu Ile Lys Leu Pro Ser Leu Lys Gln
                 645                 650                 655

 ctg aac ctg tgg tcc act cag ttt gga gac gct ggc ctt cgg ctc ctg     2075
 Leu Asn Leu Trp Ser Thr Gln Phe Gly Asp Ala Gly Leu Arg Leu Leu
             660                 665                 670

 tcg gaa cac ctc acc atg ctc cag gtg ctg aac ctg tgc gag acc ccg     2123
 Ser Glu His Leu Thr Met Leu Gln Val Leu Asn Leu Cys Glu Thr Pro
         675                 680                 685

 gtc aca gac gct ggc ctg ctg gcc ctg agc tcc atg aag agt ctc tgc     2171
 Val Thr Asp Ala Gly Leu Leu Ala Leu Ser Ser Met Lys Ser Leu Cys
     690                 695                 700

 agt tta aac atg aac agc acc aag ctc tca gct gac acc tac gaa gat     2219
 Ser Leu Asn Met Asn Ser Thr Lys Leu Ser Ala Asp Thr Tyr Glu Asp
 705                 710                 715                 720

 ctg aag gcc aag ctt ccc aat ttg aag gaa gtg gac gtc cgc tac acc     2267
 Leu Lys Ala Lys Leu Pro Asn Leu Lys Glu Val Asp Val Arg Tyr Thr
                 725                 730                 735

 gaa gcc tgg tga agc tcccagctca aggcaggaag acgtttgcaa ccgcgacaaa     2322
 Glu Ala Trp 


 ataactcttg actaacagcc gcagagcagc cggtcctggg gtcccaccct ggtgccctgg   2382

 ctgtgagata gatggggagt ctttctgggg gcggaggggg gagggggtgg ggagggggcc   2442

 cacaagcacg cccagcccac gccgaattct tttagcttcg taattggaac ctttgacctg   2502

 atctaaagtg gactttgtag caacaagagg agcatcagcg ggtcggggag gggtttgggg   2562

 gtgggctggg gggtggggga ccctttgtgg attttctttg cctttgtgtt tgatgccgtc   2622

 gtgtgggaaa agtcaactcc gatgccacca ttgcgggccg gacgaaggat gctttcttcc   2682

 tagaggctcc gagctgagct gcgaactcgc cccccgccct tgggacaaga agacccagtc   2742

 acatcactgc acccgtcctg tgtcctcacc attgctatgc aaagtgattc ttgttgtaca   2802

 taagatttaa ataatgcacc tatttaagac atgttgacaa attgcgggtc tgggacccgc   2862

 ctcttattta tgaagtcttt gaccgtcccc cccgcccgac cccaccgccc tcccgccccc   2922

 acctggcgtg tagtactgta taaaccagtc agctgtcggg ttagtggtag tattattgtt   2982

 atttttttaa aggaaacaaa cagacaacaa aaaaaaaaaa aaaaaaaaaa aacctccttg   3042

 gaaaaattaa ttgctttttc gtaatggatt ctctatgcta atgctctctc gtctgtctgt   3102

 ctgtctgccc actcccccac ccaccactgt gcgtttctga tttccaaatg tctccaactc   3162

 cctcacgagg tggggctcag gctggaggag gagggattaa gatccccttg ctccactaag   3222

 gcccaagctc tttctctcgg caccttttag acttgaatgg gaggctgcta acccgccctc   3282

 tccagtccac cccggtaaaa gagctgttcc ccacccccag ggagctcctg tccctgtcag   3342

 cctttgctgt cccctgtccc caacggagac tctgtcaccc ctgggctccc cctgccatcg   3402

 tgtgcttcac gtggccccat gcatgcccgc ctctctgcat ggtctcttgg gaaaagagag   3462

 atgtgtcgcc tccgccagtc cgactgccct ccccacccca cccccgccac cccccacatg   3522

 tgaccactgc aacgaagaca ctccttctgt ccccacctgc tccgaagaca aaccaacctc   3582

 cgtttctttt ataaacagtc ggctttttct taataagccc tcactgtaca gaacagcccg   3642

 ttgatggttt atttggggtc cccctctccc cccagccctt ttttctgttg gtttagcaca   3702

 aatacttccc tcctccggca cctccaaacc taccccacag tcagtgtact tgttttatat   3762

 atatttaatc ttattcaatg gaaaccatgc ttttgtcgtt ttatactttg ctaggtagac   3822

 tttattaccc ccccactatg ccctcatttt tttaaaaaag gaaaaaaaaa agaaactggg   3882

 ttccagtctt aattcatttt ccgtgccagg ttttatttcg tgtgtgtgtg agtgtgttct   3942

 gttttgtgtt ttgttttttg ttgttgtttt cagttgtttg gttttctttt ctttcccccc   4002

 tccggtccca tacttcacag cactctggtg cgggaagaag cagaagcaaa aaaaataaaa   4062

 ataaaaaaat aaataaaaat aaaaaaaata aaaaaggaaa aaaaaaaaga agaaacaaga   4122

 catgccacct ttcccctcgc actgttgctt ttcctgatgg ttaatactac tgtcacgtag   4182

 ctgtgtacaa agagatgtga aatactttca ggcaaaaata aactgtaagt gactcatcaa   4242

 aaaaaaaaaa agggggggcc gtttaaaaga atccaattta acgaacccgg gcaggcaacg   4302

 taaaattttt ttaatagggc caccaaaatt aaatcaatgg gccgcggttt aaaaacgcgg   4362

 gaatgggaaa aaccttgggg taaccaaatt aaatcgcct                          4401




      <210> 9
      <211> 214
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (26)..(214)

      <400> 9
 gccaggattt aagtttacct caaaa  atg gaa aat ttt ggc tgg gaa aat tac      52
                              Met Glu Asn Phe Gly Trp Glu Asn Tyr
                                1               5

 atg tgg gaa gac atc ttc agt gga gat ttt agt aat tac agt ttc agc      100
 Met Trp Glu Asp Ile Phe Ser Gly Asp Phe Ser Asn Tyr Ser Phe Ser
  10                  15                  20                  25

 tat gac cct acc cct ttt cta cta gat tct gcc cca tgt tgg cca gaa      148
 Tyr Asp Pro Thr Pro Phe Leu Leu Asp Ser Ala Pro Cys Trp Pro Glu
                  30                  35                  40

 tcc cta gaa atc aat tat gtt ttg atc atc atc tat gcc ctg atg ttt      196
 Ser Leu Glu Ile Asn Tyr Val Leu Ile Ile Ile Tyr Ala Leu Met Phe
              45                  50                  55

 cta ctg aac gtg atg tga                                              214
 Leu Leu Asn Val Met 
          60





      <210> 10
      <211> 2762
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (148)..(1602)

      <400> 10
 gtggggtcgt atcccgcggg tggaggccgg ggtggcgccg gccggggcgg gggagcccaa     60

 aagaccggct gccgcctgct ccccggaaaa gggcactcgt ctccgtgggt gtggcggagc    120

 gcgcggtgca tggaatgggc tatgtga    atg aaa aaa ggt atc cgt tat gaa     171
                                  Met Lys Lys Gly Ile Arg Tyr Glu
                                    1               5

 act tcc aga aaa acg agc tac att ttt cag cag ccg cag cac ggt cct      219
 Thr Ser Arg Lys Thr Ser Tyr Ile Phe Gln Gln Pro Gln His Gly Pro
      10                  15                  20

 tgg caa aca agg atg aga aaa ata tcc aac cac ggg agc ctg cgg gtg      267
 Trp Gln Thr Arg Met Arg Lys Ile Ser Asn His Gly Ser Leu Arg Val
  25                  30                  35                  40

 gcg aag gtg gca tac ccc ctg ggg ctg tgt gtg ggc gtg ttc atc tat      315
 Ala Lys Val Ala Tyr Pro Leu Gly Leu Cys Val Gly Val Phe Ile Tyr
                  45                  50                  55

 gtt gcc tac atc aag tgg cac cgg gcc acc gcc acc cag gcc ttc ttc      363
 Val Ala Tyr Ile Lys Trp His Arg Ala Thr Ala Thr Gln Ala Phe Phe
              60                  65                  70

 agc atc acc agg gca gcc ccg ggg gcc cgg tgg ggt cag cag gcc cac      411
 Ser Ile Thr Arg Ala Ala Pro Gly Ala Arg Trp Gly Gln Gln Ala His
          75                  80                  85

 agc ccc ctg ggg aca gct gca gac ggg cac gag gtc ttc tac ggg atc      459
 Ser Pro Leu Gly Thr Ala Ala Asp Gly His Glu Val Phe Tyr Gly Ile
      90                  95                 100

 atg ttt gat gca gga agc act ggc acc cga gta cac gtc ttc cag ttc      507
 Met Phe Asp Ala Gly Ser Thr Gly Thr Arg Val His Val Phe Gln Phe
 105                 110                 115                 120

 acc cgg ccc ccc aga gaa act ccc acg tta acc cac gaa acc ttc aaa      555
 Thr Arg Pro Pro Arg Glu Thr Pro Thr Leu Thr His Glu Thr Phe Lys
                 125                 130                 135

 gca gtg aag cca ggt ctt tct gcc tat gct gat gat gtt gaa aag agc      603
 Ala Val Lys Pro Gly Leu Ser Ala Tyr Ala Asp Asp Val Glu Lys Ser
             140                 145                 150

 gct cag gga atc cgg gaa cta ctg gat gtt gct aaa cag gac att ccg      651
 Ala Gln Gly Ile Arg Glu Leu Leu Asp Val Ala Lys Gln Asp Ile Pro
         155                 160                 165

 ttc gac ttc tgg aag gcc acc cct ctg gtc ctc aag gcc aca gct ggc      699
 Phe Asp Phe Trp Lys Ala Thr Pro Leu Val Leu Lys Ala Thr Ala Gly
     170                 175                 180

 tta cgc ctg tta cct gga gaa aag gcc cag aag tta ctg cag aag gtg      747
 Leu Arg Leu Leu Pro Gly Glu Lys Ala Gln Lys Leu Leu Gln Lys Val
 185                 190                 195                 200

 aaa gaa gta ttt aaa gca tcg cct ttc ctt gta ggg gat gac tgt gtt      795
 Lys Glu Val Phe Lys Ala Ser Pro Phe Leu Val Gly Asp Asp Cys Val
                 205                 210                 215

 tcc atc atg aac gga aca gat gaa ggc gtt tcg gcg tgg atc acc atc      843
 Ser Ile Met Asn Gly Thr Asp Glu Gly Val Ser Ala Trp Ile Thr Ile
             220                 225                 230

 aac ttc ctg aca ggc agc ttg aaa act cca gga ggg agc agc gtg ggc      891
 Asn Phe Leu Thr Gly Ser Leu Lys Thr Pro Gly Gly Ser Ser Val Gly
         235                 240                 245

 atg ctg gac ttg ggc gga gga tcc act cag atc gcc ttc ctg cca cgc      939
 Met Leu Asp Leu Gly Gly Gly Ser Thr Gln Ile Ala Phe Leu Pro Arg
     250                 255                 260

 gtg gag ggc acc ctg cag gcc tcc cca ccc ggc tac ctg acg gca ctg      987
 Val Glu Gly Thr Leu Gln Ala Ser Pro Pro Gly Tyr Leu Thr Ala Leu
 265                 270                 275                 280

 cgg atg ttt aac agg acc tac aag ctc tat tcc tac agc tac ctc ggg     1035
 Arg Met Phe Asn Arg Thr Tyr Lys Leu Tyr Ser Tyr Ser Tyr Leu Gly
                 285                 290                 295

 ctc ggg ctg atg tcg gca cgc ctg gcg atc ctg ggc ggc gtg gag ggg     1083
 Leu Gly Leu Met Ser Ala Arg Leu Ala Ile Leu Gly Gly Val Glu Gly
             300                 305                 310

 cag cct gct aag gat gga aag gag ttg gtc agc cct tgc ttg tct ccc     1131
 Gln Pro Ala Lys Asp Gly Lys Glu Leu Val Ser Pro Cys Leu Ser Pro
         315                 320                 325

 agt ttc aaa gga gag tgg gaa cac gca gaa gtc acg tac agg gtt tca     1179
 Ser Phe Lys Gly Glu Trp Glu His Ala Glu Val Thr Tyr Arg Val Ser
     330                 335                 340

 ggg cag aaa gca gcg gca agc ctg cac gag ctg tgt gct gcc aga gtg     1227
 Gly Gln Lys Ala Ala Ala Ser Leu His Glu Leu Cys Ala Ala Arg Val
 345                 350                 355                 360

 tca gag gtc ctt caa aac aga gtg cac agg acg gag gaa gtg aag cat     1275
 Ser Glu Val Leu Gln Asn Arg Val His Arg Thr Glu Glu Val Lys His
                 365                 370                 375

 gtg gac ttc tat gct ttc tcc tac tat tac gac ctt gca gct ggt gtg     1323
 Val Asp Phe Tyr Ala Phe Ser Tyr Tyr Tyr Asp Leu Ala Ala Gly Val
             380                 385                 390

 ggc ctc ata gat gcg gag aag gga ggc agc ctg gtg gtg ggg gac ttc     1371
 Gly Leu Ile Asp Ala Glu Lys Gly Gly Ser Leu Val Val Gly Asp Phe
         395                 400                 405

 gag atc gca gcc aag tac gtg tgt cgg acc ctg gag aca cag ccg cag     1419
 Glu Ile Ala Ala Lys Tyr Val Cys Arg Thr Leu Glu Thr Gln Pro Gln
     410                 415                 420

 agc agc ccc ttc tca tgc atg gac ctc acc tac gtc agc ctg cta ctc     1467
 Ser Ser Pro Phe Ser Cys Met Asp Leu Thr Tyr Val Ser Leu Leu Leu
 425                 430                 435                 440

 cag gag ttc ggc ttt ccc agg agc aaa gtg ctg aag ctc act cgg aaa     1515
 Gln Glu Phe Gly Phe Pro Arg Ser Lys Val Leu Lys Leu Thr Arg Lys
                 445                 450                 455

 att gac aat gtt gag acc agc tgg gct ctg ggg gcc att ttt cat tac     1563
 Ile Asp Asn Val Glu Thr Ser Trp Ala Leu Gly Ala Ile Phe His Tyr
             460                 465                 470

 atc gac tcc ctg aac aga cag aag agt cca gcc tca tag tggccgagcc      1612
 Ile Asp Ser Leu Asn Arg Gln Lys Ser Pro Ala Ser 
         475                 480

 atccctgtcc ccgtcagcag tgtctgtgtg tctgcataaa ccctcctgtc ctggacgtga   1672

 cttcatcctg aggagccaca gcacaggccg tgctggcact ttctgcacac tggctctggg   1732

 acttgcagaa ggcctggtgc tgccctggca tcagcctctt ccagtcacat ctggccagag   1792

 ggctgtctgg acctgggccc tgctcaatgc cacctgtctg cctgggctcc aagtgggcag   1852

 gaccaggaca gaaccacagg cacacactga gggggcagtg tggctccctg cctgtcccat   1912

 ccccatgccc cgtccgcggg gctgtggctg ctgctgtgca tgtccctgcg atgggagtct   1972

 tgtctcccag cctgtcagtt tcctccccag ggcagagctc cccttcctgc aagagtctgg   2032

 gaggcggtgc aggctgtcct ggctgctctg gggaagccga gggacagcca taacaccccc   2092

 gggacagtag gtctgggcgg caccactggg aactctggac ttgagtgtgt ttgctcttcc   2152

 ttgggtatga atgtgtgagt tcacccagag gcctgctctc ctcacacatt gtgtggtttg   2212

 gggttaatga tggagggaga cacctcttca tagacggcag gtgcccacct ttcagggagt   2272

 ctcccagcat gggcggatgc cgggcatgag ctgctgtaaa ctatttgtgg ctgtgctgct   2332

 tgagtgacgt ctctgtcgtg tgggtgccaa gtgcttgtgt agaaactgtg ttctgagccc   2392

 ccttttctgg acaccaactg tgtcctgtga atgtatcgct actgtgagct gttcccgcct   2452

 agccagggcc atgtcttagg tgcagctgtg ccacgggtca gctgagccac agtcccagaa   2512

 ccaagctctc ggtgtctcgg gccaccatcc gcccacctcg ggctgacccc acctcctcca   2572

 tggacagtgt gagccccggg ccgtgcatcc tgctcagtgt ggcgtcagtg tcggggctga   2632

 gccccttgag ctgcttcagt gaatgtacag tgcccggcac gagctgaacc tcatgtgttc   2692

 cactcccaat aaaaggttga caggggcttc tccttcaaaa aaaaaaaaaa aaaaaaaaaa   2752

 aaaaaaaaaa                                                          2762




      <210> 11
      <211> 1092
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1092)

      <400> 11
  atg ggc ccc ggc gag gcg ctg ctg gcg ggt ctc ctg gtg atg gta ctg      48
  Met Gly Pro Gly Glu Ala Leu Leu Ala Gly Leu Leu Val Met Val Leu
    1               5                  10                  15

 gcc gtg gcg ctg cta tcc aac gca ctg gtg ctg ctt tgt tgc gcc tac       96
 Ala Val Ala Leu Leu Ser Asn Ala Leu Val Leu Leu Cys Cys Ala Tyr
              20                  25                  30

 agc gct gag ctc cgc act cga gcc tca ggc gtc ctc ctg gtg aat ctg      144
 Ser Ala Glu Leu Arg Thr Arg Ala Ser Gly Val Leu Leu Val Asn Leu
          35                  40                  45

 tct ctg ggc cac ctg ctg ctg gcg gcg ctg gac atg ccc ttc acg ctg      192
 Ser Leu Gly His Leu Leu Leu Ala Ala Leu Asp Met Pro Phe Thr Leu
      50                  55                  60

 ctc ggt gtg atg cgc ggg cgg aca ccg tcg gcg ccc ggc gca tgc caa      240
 Leu Gly Val Met Arg Gly Arg Thr Pro Ser Ala Pro Gly Ala Cys Gln
  65                  70                  75                  80

 gtc att ggc ttc ctg gac acc ttc ctg gcg tcc aac gcg gcg ctg agc      288
 Val Ile Gly Phe Leu Asp Thr Phe Leu Ala Ser Asn Ala Ala Leu Ser
                  85                  90                  95

 gtg gcg gcg ctg agc gca gac cag tgg ctg gca gtg ggc ttc cca ctg      336
 Val Ala Ala Leu Ser Ala Asp Gln Trp Leu Ala Val Gly Phe Pro Leu
             100                 105                 110

 cgc tac gcc gga cgc ctg cga ccg cgc tat gcc ggc ctg ctg ctg ggc      384
 Arg Tyr Ala Gly Arg Leu Arg Pro Arg Tyr Ala Gly Leu Leu Leu Gly
         115                 120                 125

 tgt gcc tgg gga cag tcg ctg gcc ttc tca ggc gct gca ctt ggc tgc      432
 Cys Ala Trp Gly Gln Ser Leu Ala Phe Ser Gly Ala Ala Leu Gly Cys
     130                 135                 140

 tcg tgg ctt ggc tac agc agc gcc ttc gcg tcc tgt tcg ctg cgc ctg      480
 Ser Trp Leu Gly Tyr Ser Ser Ala Phe Ala Ser Cys Ser Leu Arg Leu
 145                 150                 155                 160

 ccg ccc gag cct gag cgt ccg cgc ttc gca gcc ttc acc gcc acg ctc      528
 Pro Pro Glu Pro Glu Arg Pro Arg Phe Ala Ala Phe Thr Ala Thr Leu
                 165                 170                 175

 cat gcc gtg ggc ttc gtg ctg ccg ctg gcg gtg ctc tgc ctc acc tcg      576
 His Ala Val Gly Phe Val Leu Pro Leu Ala Val Leu Cys Leu Thr Ser
             180                 185                 190

 ctc cag gtg cac cgg gtg gca cgc aga cac tgc cag cgc atg gac acc      624
 Leu Gln Val His Arg Val Ala Arg Arg His Cys Gln Arg Met Asp Thr
         195                 200                 205

 gtc acc atg aag gcg ctc gcg ctg ctc gcc gac ctg cac ccc agt gtg      672
 Val Thr Met Lys Ala Leu Ala Leu Leu Ala Asp Leu His Pro Ser Val
     210                 215                 220

 cgg cag cgc tgc ctc atc cag cag aag cgg cgc cgc cac cgc gcc acc      720
 Arg Gln Arg Cys Leu Ile Gln Gln Lys Arg Arg Arg His Arg Ala Thr
 225                 230                 235                 240

 agg aag att ggc att gct att gcg acc ttc ctc atc tgc ttt gcc ccg      768
 Arg Lys Ile Gly Ile Ala Ile Ala Thr Phe Leu Ile Cys Phe Ala Pro
                 245                 250                 255

 tat gtc atg acc agg ctg gcg gag ctc gtg ccc ttc gtc acc gtg aac      816
 Tyr Val Met Thr Arg Leu Ala Glu Leu Val Pro Phe Val Thr Val Asn
             260                 265                 270

 gcc cag tgg ggc atc ctc agc aag tgc ctg acc tac agc aag gcg gtg      864
 Ala Gln Trp Gly Ile Leu Ser Lys Cys Leu Thr Tyr Ser Lys Ala Val
         275                 280                 285

 gcc gac ccg ttc acg tac tct ctg ctc cgc cgg ccg ttc cgc caa gtc      912
 Ala Asp Pro Phe Thr Tyr Ser Leu Leu Arg Arg Pro Phe Arg Gln Val
     290                 295                 300

 ctg gcc ggc atg gtg cac cgg ctg ctg aag aga acc ccg cgc cca gca      960
 Leu Ala Gly Met Val His Arg Leu Leu Lys Arg Thr Pro Arg Pro Ala
 305                 310                 315                 320

 tcc acc cat gac agc tct ctg gat gtg gcc ggc atg gtg cac cag ctg     1008
 Ser Thr His Asp Ser Ser Leu Asp Val Ala Gly Met Val His Gln Leu
                 325                 330                 335

 ctg aag aga acc ccg cgc cca gcg tcc acc cac aac ggc tct gtg gac     1056
 Leu Lys Arg Thr Pro Arg Pro Ala Ser Thr His Asn Gly Ser Val Asp
             340                 345                 350

 aca gag aat gat tcc tgc ctg cag cag aca cac tga                     1092
 Thr Glu Asn Asp Ser Cys Leu Gln Gln Thr His 
         355                 360





      <210> 12
      <211> 996
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (38)..(982)

      <400> 12
 ccgaccacat ttcactctca ccgctgtggg aatccag atg cag gcc aag tac agc      55
                                          Met Gln Ala Lys Tyr Ser
                                            1               5

 agc acg atg gac atg ctg gat gat gat ggg gac acc acc atg agc ctg      103
 Ser Thr Met Asp Met Leu Asp Asp Asp Gly Asp Thr Thr Met Ser Leu
              10                  15                  20

 cat tct caa gcc tct gcc aca act cgg cat cca gag ccc cgg cgc aca      151
 His Ser Gln Ala Ser Ala Thr Thr Arg His Pro Glu Pro Arg Arg Thr
          25                  30                  35

 gag cac agg gct ccc tct tca acg tgg cga cca gtg gcc ctg acc ctg      199
 Glu His Arg Ala Pro Ser Ser Thr Trp Arg Pro Val Ala Leu Thr Leu
      40                  45                  50

 ctg act ttg tgc ttg gtg ctg ctg ata ggg ctg gca gcc ctg ggg ctt      247
 Leu Thr Leu Cys Leu Val Leu Leu Ile Gly Leu Ala Ala Leu Gly Leu
  55                  60                  65                  70

 ttg ttt ttt cag tac tac cag ctc tcc aat act ggt caa gac acc att      295
 Leu Phe Phe Gln Tyr Tyr Gln Leu Ser Asn Thr Gly Gln Asp Thr Ile
                  75                  80                  85

 tct caa atg gaa gaa aga tta gga aat acg tcc caa gag ttg caa tct      343
 Ser Gln Met Glu Glu Arg Leu Gly Asn Thr Ser Gln Glu Leu Gln Ser
              90                  95                 100

 ctt caa gtc cag aat ata aag ctt gca gga agt ctg cag cat gtg gct      391
 Leu Gln Val Gln Asn Ile Lys Leu Ala Gly Ser Leu Gln His Val Ala
         105                 110                 115

 gaa aaa ctc tgt cgt gag ctg tat aac aaa gct gga ggc tat aca aga      439
 Glu Lys Leu Cys Arg Glu Leu Tyr Asn Lys Ala Gly Gly Tyr Thr Arg
     120                 125                 130

 aac atg gtg cca gca tct gct tct tct gag agc ctc agg cag ctt cca      487
 Asn Met Val Pro Ala Ser Ala Ser Ser Glu Ser Leu Arg Gln Leu Pro
 135                 140                 145                 150

 cac atg ggg gaa agt gca gca gca cac agg tgc agc cct tgt aca gaa      535
 His Met Gly Glu Ser Ala Ala Ala His Arg Cys Ser Pro Cys Thr Glu
                 155                 160                 165

 caa tgg aaa tgg cat gga gac aat tgc tac cag ttc tat aaa gac agc      583
 Gln Trp Lys Trp His Gly Asp Asn Cys Tyr Gln Phe Tyr Lys Asp Ser
             170                 175                 180

 aaa agt tgg gag gac tgt aaa tat ttc tgc ctt agt gaa aac tct acc      631
 Lys Ser Trp Glu Asp Cys Lys Tyr Phe Cys Leu Ser Glu Asn Ser Thr
         185                 190                 195

 atg ctg aag ata aac aaa caa gaa gac ctg gaa ttt gcc gcg tct cag      679
 Met Leu Lys Ile Asn Lys Gln Glu Asp Leu Glu Phe Ala Ala Ser Gln
     200                 205                 210

 agc tac tct gag ttt ttc tac tct tat tgg aca ggg ctt ttg cgc cct      727
 Ser Tyr Ser Glu Phe Phe Tyr Ser Tyr Trp Thr Gly Leu Leu Arg Pro
 215                 220                 225                 230

 gac agt ggc aag gcc tgg ctg tgg atg gat gga acc cct ttc act tct      775
 Asp Ser Gly Lys Ala Trp Leu Trp Met Asp Gly Thr Pro Phe Thr Ser
                 235                 240                 245

 gaa ctg ttc cat att ata ata gat gtc acc agc cca aga agc aga gac      823
 Glu Leu Phe His Ile Ile Ile Asp Val Thr Ser Pro Arg Ser Arg Asp
             250                 255                 260

 tgt gtg gcc atc ctt aat ggg atg atc ttc tca aag gac tgc aaa gaa      871
 Cys Val Ala Ile Leu Asn Gly Met Ile Phe Ser Lys Asp Cys Lys Glu
         265                 270                 275

 ttg aag cgt tgt gtc tgt gag aga agg gca gga atg gtg aag cca gag      919
 Leu Lys Arg Cys Val Cys Glu Arg Arg Ala Gly Met Val Lys Pro Glu
     280                 285                 290

 agc ctc cat gtc ccc cct gaa aca tta ggc gaa ggt gac atg cat cat      967
 Ser Leu His Val Pro Pro Glu Thr Leu Gly Glu Gly Asp Met His His
 295                 300                 305                 310

 cat cat cat cat tag cctaggttct agac                                  996
 His His His His 






      <210> 13
      <211> 1780
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (480)..(662)

      <400> 13
 gacaactgtt tgcaatataa aaagctcatt tactgtaata tttatgatac agtgaatatg     60

 aaaatgcact ggtcagaagg cactctcaaa gagccgcact gctcctgaca tcgtccttag    120

 caatgaaatc acaaagacag ccaaagcagt cctgcttctt ggaaatcaga agctgccttt    180

 atcacatata aagccaaaca gggcataacc atgtcacgtg agcatgtcat caggcttctg    240

 aggacttgtt ctttataaaa aaagaccttc acaaaatatc ttggcttaga gatagcagtc    300

 tttattaaca aaggccacct aggctgacac ctgcagataa tcatctcctt ttctttgtct    360

 atgttgtaca ttttcatgat ataactttta actatgtcta gagaaggcag gctctgcaag    420

 agaggtgccc tttcaacccg ctcagtgccc tggacaggag atgctgtgtt aaactgtta     479                                                                 
 atg gat atc tat atg aga agc tca ttt ttg tat gct atc cct gca gtt      527
 Met Asp Ile Tyr Met Arg Ser Ser Phe Leu Tyr Ala Ile Pro Ala Val
   1               5                  10                  15

 ttt ttt ttt cta aca ggc cca tgt ttg aga ata aac aag tct gtg atg      575
 Phe Phe Phe Leu Thr Gly Pro Cys Leu Arg Ile Asn Lys Ser Val Met
              20                  25                  30

 tca gag aca aag gtg tat tct tca gtc tgc agg tgt gtg gca cct ccc      623
 Ser Glu Thr Lys Val Tyr Ser Ser Val Cys Arg Cys Val Ala Pro Pro
          35                  40                  45

 ttc tcc cct gca gcc ccc cac atc cag agc cgt tcc tga gagtgacatc       672
 Phe Ser Pro Ala Ala Pro His Ile Gln Ser Arg Ser 
      50                  55                  60

 atgcatcaag aaaacataac cttggtcctc aggtgaaccc ttggaacatt ctgtgaccgc    732

 ctgatgtcca ttctgagcca ccttggcaca catgcttaca ggcagcactg ctaagggttc    792

 aggtgcccca tggctgacag cccgagttgc ttctgtggac catcatgccg ctcggcacgt    852

 cctgagacag aagttgctgc aggaaggagc ttctggagag gtcctgtggc atgtgtgggg    912

 gtgtgtgtgt gtatgtttcc ttcttgaaca gacattccaa ctttagatgt gtttatagaa    972

 ctgacctttt tactaacaaa atacaatgat atatgttgga aactacttaa tatgcttttc   1032

 ctgcacacct tagcaataac tgtaggggtc tctgctagag ttgtttgtat gtacagcaat   1092

 tttgaacaaa ttgttttaaa tgtaatataa gagaattagt ttaaggaagt aaagagaatc   1152

 atttgcttgt gttacatttt cagtgaggat tcagtttaag agtcattctt aggacttcca   1212

 tttcctaata tttattcatg ggtaatgaag aaatggtttg cattttgtgg ccagtcctaa   1272

 tttattttcc agctgagccc taacttccgg ctcccaccta cctccacgga cttcctaaca   1332

 gagacttatg aataccagga tgtgtttttg ttaagtcagg ttcaattcgt tgcccctgtc   1392

 agttttatag agtgtgaggg tcactccatt aaagatctct cctgggtgga tcctacttgg   1452

 atgttcaggt gattttgaaa actgctaaca tttttaaaag gctagaacat cctttgactt   1512

 cttgaaaatc tgcatgtctg gcttgggttt tattaccaca tgcctgagtt cttcaagaat   1572

 ggaaggctca agtattctca tcttccattt gccaaacttc cttcctgatt tgagtcacat   1632

 gttccacttg gaaagaaagg gaacagagag cctcctccat ggacagtgta tgaatttcat   1692

 tgggaatctt gctctctccc gcctctatgc ctttctctct ttttaacctt actttacata   1752

 atattataga tgggccaaaa aaaaaaaa                                      1780




      <210> 14
      <211> 1601
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (246)..(1463)

      <400> 14
 gcgggctgcc gcgcaagggt ggcgcgcgcg cgttttcctt gttcctggtc aacaaagaaa     60

 tgtggagtgt cttggctgaa tcctcataca gacaagatca ttatggtgct gttaggttga    120

 aaaagtgata taataaagga accaaggaga aaattcagaa ggaaagaaaa aattgcctct    180

 gcaggtgtgc gagcaggatt gcttctgcaa caaaagcctc cacccagcca catcttggga    240

 aaaga    atg gcc act tct tgg ggc aca gtc ttt ttc atg ctg gtg gta     287
          Met Ala Thr Ser Trp Gly Thr Val Phe Phe Met Leu Val Val
            1               5                  10

 tcc tgt gtt tgc agc gct gtc tcc cac agg aac cag cag act tgg ttt      335
 Ser Cys Val Cys Ser Ala Val Ser His Arg Asn Gln Gln Thr Trp Phe
  15                  20                  25                  30

 gag ggt atc ttc ctg tct tcc atg tgc ccc atc aat gtc agc gcc agc      383
 Glu Gly Ile Phe Leu Ser Ser Met Cys Pro Ile Asn Val Ser Ala Ser
                  35                  40                  45

 acc ttg tat gga att atg ttt gat gca ggg agc act gga act cga att      431
 Thr Leu Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly Thr Arg Ile
              50                  55                  60

 cat gtt tac acc ttt gtg cag aaa atg cca gga cag ctt cca att cta      479
 His Val Tyr Thr Phe Val Gln Lys Met Pro Gly Gln Leu Pro Ile Leu
          65                  70                  75

 gaa ggg gaa gtt ttt gat tct gtg aag cca gga ctt tct gct ttt gta      527
 Glu Gly Glu Val Phe Asp Ser Val Lys Pro Gly Leu Ser Ala Phe Val
      80                  85                  90

 gat caa cct aag cag ggt gct gag acc gtt caa ggg ctc tta gag gtg      575
 Asp Gln Pro Lys Gln Gly Ala Glu Thr Val Gln Gly Leu Leu Glu Val
  95                 100                 105                 110

 gcc aaa gac tca atc ccc cga agt cac tgg aaa aag acc cca gtg gtc      623
 Ala Lys Asp Ser Ile Pro Arg Ser His Trp Lys Lys Thr Pro Val Val
                 115                 120                 125

 cta aag gca aca gca gga cta cgc tta ctg cca gaa cac aaa gcc aag      671
 Leu Lys Ala Thr Ala Gly Leu Arg Leu Leu Pro Glu His Lys Ala Lys
             130                 135                 140

 gct ctg ctc ttt gag gta aag gag atc ttc agg aag tca cct ttc ctg      719
 Ala Leu Leu Phe Glu Val Lys Glu Ile Phe Arg Lys Ser Pro Phe Leu
         145                 150                 155

 gta cca aag ggc agt gtt agc atc atg gat gga tcc gac gaa ggc ata      767
 Val Pro Lys Gly Ser Val Ser Ile Met Asp Gly Ser Asp Glu Gly Ile
     160                 165                 170

 tta gct tgg gtt act gtg aat ttt ctg aca ggt cag ctg cat ggc cac      815
 Leu Ala Trp Val Thr Val Asn Phe Leu Thr Gly Gln Leu His Gly His
 175                 180                 185                 190

 aga cag gag act gtg ggg acc ttg gac cta ggg gga gcc tcc acc caa      863
 Arg Gln Glu Thr Val Gly Thr Leu Asp Leu Gly Gly Ala Ser Thr Gln
                 195                 200                 205

 atc acg ttc ctg ccc cag ttt gag aaa act ctg gaa caa act cct agg      911
 Ile Thr Phe Leu Pro Gln Phe Glu Lys Thr Leu Glu Gln Thr Pro Arg
             210                 215                 220

 ggc tac ctc act tcc ttt gag atg ttt aac agc act tat aag ctc tat      959
 Gly Tyr Leu Thr Ser Phe Glu Met Phe Asn Ser Thr Tyr Lys Leu Tyr
         225                 230                 235

 aca cat agt tac ctg gga ttt gga ttg aaa gct gca aga cta gca acc     1007
 Thr His Ser Tyr Leu Gly Phe Gly Leu Lys Ala Ala Arg Leu Ala Thr
     240                 245                 250

 ctg gga gcc ctg gag aca gaa ggg act gat ggg cac act ttc cgg agt     1055
 Leu Gly Ala Leu Glu Thr Glu Gly Thr Asp Gly His Thr Phe Arg Ser
 255                 260                 265                 270

 gcc tgt tta ccg aga tgg ttg gaa gca gag tgg atc ttt ggg ggt gtg     1103
 Ala Cys Leu Pro Arg Trp Leu Glu Ala Glu Trp Ile Phe Gly Gly Val
                 275                 280                 285

 aaa tac cag tat ggt ggc aac caa gaa ggg gag gtg ggc ttt gag ccc     1151
 Lys Tyr Gln Tyr Gly Gly Asn Gln Glu Gly Glu Val Gly Phe Glu Pro
             290                 295                 300

 tgc tat gcc gaa gtg ctg agg gtg gta cga gga aaa ctt cac cag cca     1199
 Cys Tyr Ala Glu Val Leu Arg Val Val Arg Gly Lys Leu His Gln Pro
         305                 310                 315

 gag gag gtc cag aga ggt tcc ttc tat gct ttc tct tac tat tat gac     1247
 Glu Glu Val Gln Arg Gly Ser Phe Tyr Ala Phe Ser Tyr Tyr Tyr Asp
     320                 325                 330

 cga gct gtt gac aca gac atg att gat tat gaa aag ggg ggt att tta     1295
 Arg Ala Val Asp Thr Asp Met Ile Asp Tyr Glu Lys Gly Gly Ile Leu
 335                 340                 345                 350

 aaa gtt gaa gat ttt gaa aga aaa gcc agg gaa gtg tgt gat aac ttg     1343
 Lys Val Glu Asp Phe Glu Arg Lys Ala Arg Glu Val Cys Asp Asn Leu
                 355                 360                 365

 gaa aac ttc acc tca ggc agt cct ttc ctg tgc atg gat ctc agc tac     1391
 Glu Asn Phe Thr Ser Gly Ser Pro Phe Leu Cys Met Asp Leu Ser Tyr
             370                 375                 380

 atc aca gcc ctg tta aag gat ggc ttt ggc ttt gca gac agc aca gtc     1439
 Ile Thr Ala Leu Leu Lys Asp Gly Phe Gly Phe Ala Asp Ser Thr Val
         385                 390                 395

 tta cag gct gcc gta ctg agg tga tgggccaagc tggagatatc cccaaagccc    1493
 Leu Gln Ala Ala Val Leu Arg 
     400                 405

 atgttgacac cctgtcctgc aagcggatgg actctgtggg ctgcatccct aagaataaag   1553

 cagagttcag gtgtgacctc tggcagcaaa aaaaaaaaaa aaaaaaaa                1601




      <210> 15
      <211> 835
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (175)..(528)

      <400> 15
 gaacacaggt gcacaagcac ggatttcctc gtggctggcg aagaaaatgt ccttcctctg     60

 gggaaagcag ccctcgggtt cttgagcgga ggttcttggc ttggggtctg tggcacccgc    120

 ttgcccctgc tcgcccctcc caccggcttg gacggttgca gtgacgctga atga  atg     177
                                                              Met
                                                                1

 aat aca att gcc tgg gag tcc ggg gag cgt gaa gag acc cgg gac ctc      225
 Asn Thr Ile Ala Trp Glu Ser Gly Glu Arg Glu Glu Thr Arg Asp Leu
               5                  10                  15

 agg gaa ccc gcg cct gca ccc tcg ggg tcg gtc ccg tcc cgc ccg ggt      273
 Arg Glu Pro Ala Pro Ala Pro Ser Gly Ser Val Pro Ser Arg Pro Gly
          20                  25                  30

 tgg gtg ggg ctg ccg cga gtc gga aga ggt ggg atg ctg ctg cct ggc      321
 Trp Val Gly Leu Pro Arg Val Gly Arg Gly Gly Met Leu Leu Pro Gly
      35                  40                  45

 ggt gct gca gtg gcg gat ctt cag gag gag gtc ctg ggc ttc ggc tgg      369
 Gly Ala Ala Val Ala Asp Leu Gln Glu Glu Val Leu Gly Phe Gly Trp
  50                  55                  60                  65

 ggc acg ggg gcg gtc aac ggg gag cag agg cgg ggc gca gtt ggg aag      417
 Gly Thr Gly Ala Val Asn Gly Glu Gln Arg Arg Gly Ala Val Gly Lys
                  70                  75                  80

 cac gga gac aaa agg ggg aaa gaa gga ggg agc ggg aag cca aaa gcc      465
 His Gly Asp Lys Arg Gly Lys Glu Gly Gly Ser Gly Lys Pro Lys Ala
              85                  90                  95

 tac ggt acc gct att acc agg cgg aat ccc atc caa gta cta acc agt      513
 Tyr Gly Thr Ala Ile Thr Arg Arg Asn Pro Ile Gln Val Leu Thr Ser
         100                 105                 110

 ccc gac cct gct tag cttcaacaga tcagaggcga gccgggcgcg ttcagggtgg      568
 Pro Asp Pro Ala 
     115

 tgtggcctag acgccagcag cggcgcctgg ctgccccaag agcccggccc agccaagccc    628

 gcatgactcc aggcgtcatc gccaccccgg ggccgcgggt ctcggatcca ggacccccag    688

 aggcgctcgc ccgtgccccc gggcagctgt ctccctctac acccgaggac cgccggcctc    748

 ccagagagtc ccgccgtctc cggcggccag gcctggctca ggaccaatgt ggcaccgccc    808

 tgctgttgtt ggggggcgcc gccggag                                        835




      <210> 16
      <211> 3352
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1755)

      <400> 16
  atg gga ggc cgc gag ctg acg ata ggc gag att gat tgg aag cgg ccg      48
  Met Gly Gly Arg Glu Leu Thr Ile Gly Glu Ile Asp Trp Lys Arg Pro
    1               5                  10                  15

 tgg gct ctc gcc gcg agg ggc gtg gcg ccc ccg ccg ggc ttt ctg cct       96
 Trp Ala Leu Ala Ala Arg Gly Val Ala Pro Pro Pro Gly Phe Leu Pro
              20                  25                  30

 gcc cat ttc cca ccg ccg ggc ctg ggg cgg ggc gtt cag gag gct ctg      144
 Ala His Phe Pro Pro Pro Gly Leu Gly Arg Gly Val Gln Glu Ala Leu
          35                  40                  45

 gga aag gcg gcg gtg gcc ggc gcg ggg ggc gcg cag gcg cag agc ggc      192
 Gly Lys Ala Ala Val Ala Gly Ala Gly Gly Ala Gln Ala Gln Ser Gly
      50                  55                  60

 ggg ccg ggc gtc cgc aag gtg gcg ccc gcg ggg cgc ctg cgc gat gcg      240
 Gly Pro Gly Val Arg Lys Val Ala Pro Ala Gly Arg Leu Arg Asp Ala
  65                  70                  75                  80

 gcg ggg cga cag ctg cgg cgg cgg tgg cgg ccg ggc cgg gcc gga cgg      288
 Ala Gly Arg Gln Leu Arg Arg Arg Trp Arg Pro Gly Arg Ala Gly Arg
                  85                  90                  95

 cgc ctg cgt act gag ggg ggg acg cgg ccc ggc tgg ctg gct cct ggc      336
 Arg Leu Arg Thr Glu Gly Gly Thr Arg Pro Gly Trp Leu Ala Pro Gly
             100                 105                 110

 ggc ggc tgg gct ggg gcc gcg gtg gcg gca gcc gcg gcg gcg ggc ggc      384
 Gly Gly Trp Ala Gly Ala Ala Val Ala Ala Ala Ala Ala Ala Gly Gly
         115                 120                 125

 ggt tgg tcg tgc gcg gcg gcg gcg gcg ggt ccc gcg ggc ggc ggg gcg      432
 Gly Trp Ser Cys Ala Ala Ala Ala Ala Gly Pro Ala Gly Gly Gly Ala
     130                 135                 140

 ctg acg gcc ggg ggc gcg gcg gct gcg gcg ggc cgg gcg gcg ggc ggc      480
 Leu Thr Ala Gly Gly Ala Ala Ala Ala Ala Gly Arg Ala Ala Gly Gly
 145                 150                 155                 160

 gag cgg ggg aag atg gcg gag ctg ggg aag aag tac tgc gtg tac tgc      528
 Glu Arg Gly Lys Met Ala Glu Leu Gly Lys Lys Tyr Cys Val Tyr Cys
                 165                 170                 175

 ctg gcc gag gtg agc ccg ctg cgc ttc cgc tgc acc gag tgc cag gac      576
 Leu Ala Glu Val Ser Pro Leu Arg Phe Arg Cys Thr Glu Cys Gln Asp
             180                 185                 190

 atc gag ctg tgc ccc gag tgc ttc tcg gcc ggc gcc gag atc ggc cac      624
 Ile Glu Leu Cys Pro Glu Cys Phe Ser Ala Gly Ala Glu Ile Gly His
         195                 200                 205

 cac cgc cgc tac cac ggc tac cag ctg gtg gac ggc ggg cgc ttc acg      672
 His Arg Arg Tyr His Gly Tyr Gln Leu Val Asp Gly Gly Arg Phe Thr
     210                 215                 220

 ctc tgg ggg ccc gag gcc gag ggc ggc tgg acc agt cgc gag gag cag      720
 Leu Trp Gly Pro Glu Ala Glu Gly Gly Trp Thr Ser Arg Glu Glu Gln
 225                 230                 235                 240

 ctg ctg ctg gac gcc atc gag cag ttc ggc ttc gga aac tgg gaa gat      768
 Leu Leu Leu Asp Ala Ile Glu Gln Phe Gly Phe Gly Asn Trp Glu Asp
                 245                 250                 255

 atg gct gcc cac gtt ggt gct tcc cgg act ccc caa gag gtg atg gag      816
 Met Ala Ala His Val Gly Ala Ser Arg Thr Pro Gln Glu Val Met Glu
             260                 265                 270

 cat tac gtg agc atg tac atc cac ggg aac ctg ggg aag gcc tgc atc      864
 His Tyr Val Ser Met Tyr Ile His Gly Asn Leu Gly Lys Ala Cys Ile
         275                 280                 285

 ccc gac acc atc ccc aac cgc gtg aca gac cac acc tgt ccc agc gga      912
 Pro Asp Thr Ile Pro Asn Arg Val Thr Asp His Thr Cys Pro Ser Gly
     290                 295                 300

 ggc ccc ctc tca ccc agc ctc acc acc ccg ctg ccc ccg ctg gac atc      960
 Gly Pro Leu Ser Pro Ser Leu Thr Thr Pro Leu Pro Pro Leu Asp Ile
 305                 310                 315                 320

 tct gtg gct gag cag cag cag ctg ggc tac atg ccg ctg cgg gat gat     1008
 Ser Val Ala Glu Gln Gln Gln Leu Gly Tyr Met Pro Leu Arg Asp Asp
                 325                 330                 335

 tac gag atc gag tat gac cag gat gcc gag acg ctc atc agc ggg ctc     1056
 Tyr Glu Ile Glu Tyr Asp Gln Asp Ala Glu Thr Leu Ile Ser Gly Leu
             340                 345                 350

 tct gtc aac tat gat gac gac gac gtg gag atc gag ctg aag cgc gcc     1104
 Ser Val Asn Tyr Asp Asp Asp Asp Val Glu Ile Glu Leu Lys Arg Ala
         355                 360                 365

 cac gtg gac atg tac gtg cgg aag ctg aaa gag aga cag cgg cgg aag     1152
 His Val Asp Met Tyr Val Arg Lys Leu Lys Glu Arg Gln Arg Arg Lys
     370                 375                 380

 aac atc gcc cgt gac tac aat ctg gtg cca gcc ttc ctg ggg aag gac     1200
 Asn Ile Ala Arg Asp Tyr Asn Leu Val Pro Ala Phe Leu Gly Lys Asp
 385                 390                 395                 400

 aag aag gag aag gaa aag gcg ctg aag cgc aag atc acc aag gag gag     1248
 Lys Lys Glu Lys Glu Lys Ala Leu Lys Arg Lys Ile Thr Lys Glu Glu
                 405                 410                 415

 aag gag ctg cgc ctg aag ctg agg ccg ctg tac cag ttc atg tca tgc     1296
 Lys Glu Leu Arg Leu Lys Leu Arg Pro Leu Tyr Gln Phe Met Ser Cys
             420                 425                 430

 aag gag ttt gat gac ctt ttt gaa aac atg cac aaa gaa aaa atg ctc     1344
 Lys Glu Phe Asp Asp Leu Phe Glu Asn Met His Lys Glu Lys Met Leu
         435                 440                 445

 cgg gcc aag atc cga gaa ctg cag cgg tac cgg cga aac ggg atc acc     1392
 Arg Ala Lys Ile Arg Glu Leu Gln Arg Tyr Arg Arg Asn Gly Ile Thr
     450                 455                 460

 aag atg gaa gag tcg gca gag tac gag gca gcg cgg cat aaa cgg gag     1440
 Lys Met Glu Glu Ser Ala Glu Tyr Glu Ala Ala Arg His Lys Arg Glu
 465                 470                 475                 480

 aag agg aag gag aac aaa aac cta gcc ggc tcc aaa cgg gga aag gag     1488
 Lys Arg Lys Glu Asn Lys Asn Leu Ala Gly Ser Lys Arg Gly Lys Glu
                 485                 490                 495

 gac ggc aaa gac agc gag ttc gcc gcc att gag aac ctt cca ggc ttc     1536
 Asp Gly Lys Asp Ser Glu Phe Ala Ala Ile Glu Asn Leu Pro Gly Phe
             500                 505                 510

 gag ctc ctg tca gat cgc gag aag gtg ctc tgc agc tct tta aac ttg     1584
 Glu Leu Leu Ser Asp Arg Glu Lys Val Leu Cys Ser Ser Leu Asn Leu
         515                 520                 525

 agt cca gcc cgc tac gtg act gtg aag act att ata att aaa gac cac     1632
 Ser Pro Ala Arg Tyr Val Thr Val Lys Thr Ile Ile Ile Lys Asp His
     530                 535                 540

 ctc cag aag cgg caa gga atc ccc tcc aaa agc cgc ctt cct agc tac     1680
 Leu Gln Lys Arg Gln Gly Ile Pro Ser Lys Ser Arg Leu Pro Ser Tyr
 545                 550                 555                 560

 ctg gac aaa gtc cta aag aaa agg att ttg aat ttc ctc aca gaa agc     1728
 Leu Asp Lys Val Leu Lys Lys Arg Ile Leu Asn Phe Leu Thr Glu Ser
                 565                 570                 575

 ggc tgg atc tcc agg gac gcg tct tga agctg agacgctttg aaagccaggg     1780
 Gly Trp Ile Ser Arg Asp Ala Ser 
             580

 tgatgctcag acagtgtgcc agccaaaatg acttggggga ggggagccgc ttccccactg   1840

 ttgctctttt ttaaacaaat tgagttcctt tttttaagat agaaattctt ttcatggtcc   1900

 tctgaaagaa gcaatagtaa caatcttata ttggatcatg ggggaagcaa atgtgtgtat   1960

 tttaagtgag ttcctgcgag tcatacactg cgatgatgct ccgcctttac ccgttcagtt   2020

 gggagcttat tgtgagattg gatcatttcc ttttgagtgt tcttctcttt ggtacaaaac   2080

 ctattgtggg tgacaggagc agtgttttcc tgctggaccc gcaagccacc agctatttcc   2140

 tggtgacaca agctcttctc aggcggggct gcctgcaggc tcccgttttc tgagcccacg   2200

 ctgcccacag ctgaccccag cgcagccccg ggcacgcggc actttacatg ggggcagctt   2260

 gggcccagac tcctccgctg tgtagcagat gaggaaaatc aggccagagg acaacaggct   2320

 ggcgttttgt tgggaactga agaggaatct gttgaacaca gcgaccagat gaccttccat   2380

 ttcaccggcg gcagcagttt cagcgtgcag ttcccaaacc ccaaagctga ccctgcgccc   2440

 catttgaata cggccagagc ctgctggttc actttgggta gagccgtgcc tcttgggcag   2500

 gctcccatag tgaccacgtc cccacgaatg ggaaagcacg ttagtgggag ggacgtagga   2560

 cacgtgtgga ccgccaggcc ctctcagtcc attttccggg gctgctcggt gctgctgtta   2620

 agacgtgagt gcatttcact tggaagaacc cattgtacaa agttcaaggc taagagttct   2680

 gaattctggc gtcagcttcc tcaggatttt cttcagttgc aagtaccttt ccactgaaaa   2740

 tatgagcatg cccgcctggc tagtaggcat ctgtaagagt gtcgccaggc ccgcgccagc   2800

 tgaggcctca gactagccag gcaagagccg tctgaccagt tggctggcgg tggttctggt   2860

 ggagcacgag ggagcccggg tggtgccctg agcctcgagc tgctctctgt cactgtcttg   2920

 aatcagactc agaaatggct tcttcccagc cctgcctaca agtttttctc tggggtcctc   2980

 tttcaaggat gtccacggta ccttcctcct gaaacttgag gaagtctttt gtcttccagc   3040

 tgctcagggt tctctggtcc aagaccctgc tttaaagaga gtctttggcg tgctcagact   3100

 ccagcgctcc gttcttcaag gaggttgact tgcctctcgg gccccgtagg taccaagaga   3160

 ctgtttacct cccagaatgt ttgggcttga agttacatta aagtgaagtt atttgaaaga   3220

 aagaaaacct catcatttct aaggatgact taattactgt gccttttcct ttctttttac   3280

 acatcctact gtcccttagg gtaaaatttt cagcattaaa taaaacattt caaatatatt   3340

 gtaaaaaaaa aa                                                       3352




      <210> 17
      <211> 4876
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3183)

      <400> 17
  atg agc cct gcg gcc agc ctg ccg gct cag ccc agc cca gct ctg cca      48
  Met Ser Pro Ala Ala Ser Leu Pro Ala Gln Pro Ser Pro Ala Leu Pro
    1               5                  10                  15

 cag agc agc cac gcc agc agc acg tct gtt ttc tcg tcg ccc ggc tcc       96
 Gln Ser Ser His Ala Ser Ser Thr Ser Val Phe Ser Ser Pro Gly Ser
              20                  25                  30

 ggc ccc ggg act agt ggc gac tgc ctg ggg cgc cgg cga gac cat ggc      144
 Gly Pro Gly Thr Ser Gly Asp Cys Leu Gly Arg Arg Arg Asp His Gly
          35                  40                  45

 cga gaa gtt aag cgg gtc tgg tgg ccc ctg ggg ctg cca ccc cat ttg      192
 Arg Glu Val Lys Arg Val Trp Trp Pro Leu Gly Leu Pro Pro His Leu
      50                  55                  60

 ggt cat ctg gcc act gcc aga agc cct gtc cta gaa ggg aaa gag ctg      240
 Gly His Leu Ala Thr Ala Arg Ser Pro Val Leu Glu Gly Lys Glu Leu
  65                  70                  75                  80

 agg gac cgc gtg gag gaa cga gcc cca gaa ggc atg gac ctg ctg ctc      288
 Arg Asp Arg Val Glu Glu Arg Ala Pro Glu Gly Met Asp Leu Leu Leu
                  85                  90                  95

 ttc tct gtg gtt cag gcc ctt gcg acg tac aca cac ccg aga atg tgt      336
 Phe Ser Val Val Gln Ala Leu Ala Thr Tyr Thr His Pro Arg Met Cys
             100                 105                 110

 gtg tcc ctg tac gtg aac ccg agt gtg ccc acg tac acg tac cca act      384
 Val Ser Leu Tyr Val Asn Pro Ser Val Pro Thr Tyr Thr Tyr Pro Thr
         115                 120                 125

 gtc ctc atg tac acg tac ccg agt gtg ctc atg tac acg tac ccg agt      432
 Val Leu Met Tyr Thr Tyr Pro Ser Val Leu Met Tyr Thr Tyr Pro Ser
     130                 135                 140

 gtg ccc atg ttc atg tat ccg tgt gtg tac gta ccc gag tgt gtg tat      480
 Val Pro Met Phe Met Tyr Pro Cys Val Tyr Val Pro Glu Cys Val Tyr
 145                 150                 155                 160

 gtg cct gca tcc gtg ggc tct gag aag ctc ttt gcg ccg gga acc gat      528
 Val Pro Ala Ser Val Gly Ser Glu Lys Leu Phe Ala Pro Gly Thr Asp
                 165                 170                 175

 aaa ggc cct gcc aat gcc ggc aag gat ggg ccc tac tgc cct tca gca      576
 Lys Gly Pro Ala Asn Ala Gly Lys Asp Gly Pro Tyr Cys Pro Ser Ala
             180                 185                 190

 ggc atg gcc ttc acc tgc ctt caa gtt gga agc ctg ttc aca tca gag      624
 Gly Met Ala Phe Thr Cys Leu Gln Val Gly Ser Leu Phe Thr Ser Glu
         195                 200                 205

 cat cac agc aaa gca ggc gca gat ggg gtg gtg tca gaa ggg gcg tgc      672
 His His Ser Lys Ala Gly Ala Asp Gly Val Val Ser Glu Gly Ala Cys
     210                 215                 220

 atg gga cgg gcc ccg cct ctc tgt ggt cgc tgg gtg gtg gct gct gtg      720
 Met Gly Arg Ala Pro Pro Leu Cys Gly Arg Trp Val Val Ala Ala Val
 225                 230                 235                 240

 gaa ggc ctg gcc cca ggc cca gcg ctt gag aag tcg gag gcc aag gcc      768
 Glu Gly Leu Ala Pro Gly Pro Ala Leu Glu Lys Ser Glu Ala Lys Ala
                 245                 250                 255

 ggg ccg gtg ccc aag gtg tca ggc ctg gag cgc agc cgc gag ctc agc      816
 Gly Pro Val Pro Lys Val Ser Gly Leu Glu Arg Ser Arg Glu Leu Ser
             260                 265                 270

 gcc gag agc ttc ctg ccc act gcc agc ccc gcg ccc cat gcc gcg ccc      864
 Ala Glu Ser Phe Leu Pro Thr Ala Ser Pro Ala Pro His Ala Ala Pro
         275                 280                 285

 tgc ccg ggg ccc ccg ccc ggc tcc cgc gcc aat ccc ttg gtg aag aag      912
 Cys Pro Gly Pro Pro Pro Gly Ser Arg Ala Asn Pro Leu Val Lys Lys
     290                 295                 300

 gaa ccc ccc gcc ccg cac cgc cac acc ccg cag ccg cca ccc ccg cag      960
 Glu Pro Pro Ala Pro His Arg His Thr Pro Gln Pro Pro Pro Pro Gln
 305                 310                 315                 320

 ccc cgc ggc ctg ctc ccg aca cac gtg cct gca tcc ctg ggc gcc ttc     1008
 Pro Arg Gly Leu Leu Pro Thr His Val Pro Ala Ser Leu Gly Ala Phe
                 325                 330                 335

 gcg ggc cac agc cag gcg gca gcc aac ggc ctg cac ggc ctc agc agg     1056
 Ala Gly His Ser Gln Ala Ala Ala Asn Gly Leu His Gly Leu Ser Arg
             340                 345                 350

 agc agc agc gcc ccc ctg ggc ctg ggg aag cac gtg tcg ctg tcg cca     1104
 Ser Ser Ser Ala Pro Leu Gly Leu Gly Lys His Val Ser Leu Ser Pro
         355                 360                 365

 cac ggg ccg ggc ccc cac ctg tct acc tca cac ctg gcg ctc cgg tcc     1152
 His Gly Pro Gly Pro His Leu Ser Thr Ser His Leu Ala Leu Arg Ser
     370                 375                 380

 cag gcg cag cac cag ctc cac gcg gcc atg ttt gcc gca ccc ccg aca     1200
 Gln Ala Gln His Gln Leu His Ala Ala Met Phe Ala Ala Pro Pro Thr
 385                 390                 395                 400

 ctg ccc ccg ccc ccg gcg ctg ccg gcc agc agc ctg gtc ctc cca gga     1248
 Leu Pro Pro Pro Pro Ala Leu Pro Ala Ser Ser Leu Val Leu Pro Gly
                 405                 410                 415

 cac ccg gcc gat cac gag ctg ctc agg caa gag ctg aac acg cgg ttt     1296
 His Pro Ala Asp His Glu Leu Leu Arg Gln Glu Leu Asn Thr Arg Phe
             420                 425                 430

 ctg gtg cag agc gcc gag cgg cct ggc gcc tcc ctg ggc ccg ggg gct     1344
 Leu Val Gln Ser Ala Glu Arg Pro Gly Ala Ser Leu Gly Pro Gly Ala
         435                 440                 445

 ctg ctg cgg gcg gag ttc cat cag cac cag cac aca cac cag cac acg     1392
 Leu Leu Arg Ala Glu Phe His Gln His Gln His Thr His Gln His Thr
     450                 455                 460

 cac caa cac aca cac cag cac caa cac aca ttc gcc ccc ttc ccc gca     1440
 His Gln His Thr His Gln His Gln His Thr Phe Ala Pro Phe Pro Ala
 465                 470                 475                 480

 ggg ctg ccc ccg acg ccg ccc gcc gca ccc ccg ccg ttt gac aag tat     1488
 Gly Leu Pro Pro Thr Pro Pro Ala Ala Pro Pro Pro Phe Asp Lys Tyr
                 485                 490                 495

 gcg ccc aag ctg gac agc ccc tac ttc cga cat tcc agc gtg agt ttc     1536
 Ala Pro Lys Leu Asp Ser Pro Tyr Phe Arg His Ser Ser Val Ser Phe
             500                 505                 510

 ttc ccg tcc ttc cct cct gcc atc ccg gga ctg ccc acc ctg ctc cca     1584
 Phe Pro Ser Phe Pro Pro Ala Ile Pro Gly Leu Pro Thr Leu Leu Pro
         515                 520                 525

 cac ccc ggc ccc ttc ggg tcc ctg cag ggc gct ttt cag cct aag gtg     1632
 His Pro Gly Pro Phe Gly Ser Leu Gln Gly Ala Phe Gln Pro Lys Val
     530                 535                 540

 tct gac ccg tac cgg gcg gtg gtc aag gtg agc acg tgt tgg gaa ggc     1680
 Ser Asp Pro Tyr Arg Ala Val Val Lys Val Ser Thr Cys Trp Glu Gly
 545                 550                 555                 560

 ccg tgg caa ggg agg act ctg gtg ccc ccg ggg cgg cct cgg ggg gcc     1728
 Pro Trp Gln Gly Arg Thr Leu Val Pro Pro Gly Arg Pro Arg Gly Ala
                 565                 570                 575

 cgt gac agc agg agt ctg cag aaa aca tgg gtg ggg gtg gca cca gcc     1776
 Arg Asp Ser Arg Ser Leu Gln Lys Thr Trp Val Gly Val Ala Pro Ala
             580                 585                 590

 cca ctg agc gct tcc atc ctg tcg cag aag ccg ggg agg tgg tgt gcc     1824
 Pro Leu Ser Ala Ser Ile Leu Ser Gln Lys Pro Gly Arg Trp Cys Ala
         595                 600                 605

 gtg cac gtg cag atc gcc tgg cag atc tac cgt cac cag cag aag ata     1872
 Val His Val Gln Ile Ala Trp Gln Ile Tyr Arg His Gln Gln Lys Ile
     610                 615                 620

 aag gag atg cag ctg gac ccc cac aag ctg gag gtg ggt gca aag ctg     1920
 Lys Glu Met Gln Leu Asp Pro His Lys Leu Glu Val Gly Ala Lys Leu
 625                 630                 635                 640

 gac ctg ttc ggc aga ccc cct gcc ccg ggc gtg ttt gca ggc ttc cac     1968
 Asp Leu Phe Gly Arg Pro Pro Ala Pro Gly Val Phe Ala Gly Phe His
                 645                 650                 655

 tac cca cag gac ctg gcc cgg ccc ctc ttc ccc agc aca ggt gcc gcc     2016
 Tyr Pro Gln Asp Leu Ala Arg Pro Leu Phe Pro Ser Thr Gly Ala Ala
             660                 665                 670

 cat cct gcc tcc aac cca ttt gga ccc tca gcc cat cct ggc agc ttc     2064
 His Pro Ala Ser Asn Pro Phe Gly Pro Ser Ala His Pro Gly Ser Phe
         675                 680                 685

 ctg ccc act ggc ccc ctg aca gac cct ttc agc aga ccg agc acc ttt     2112
 Leu Pro Thr Gly Pro Leu Thr Asp Pro Phe Ser Arg Pro Ser Thr Phe
     690                 695                 700

 ggg ggc ctg ggc agc ctg agc agc cac gcc ttt ggg ggc ctg ggc agc     2160
 Gly Gly Leu Gly Ser Leu Ser Ser His Ala Phe Gly Gly Leu Gly Ser
 705                 710                 715                 720

 cat gca ctg gct ccc ggt ggc agc atc ttt gcc cca agg gag ggc tcc     2208
 His Ala Leu Ala Pro Gly Gly Ser Ile Phe Ala Pro Arg Glu Gly Ser
                 725                 730                 735

 tcc gtg cac ggc ctg ccc agc ccc cat gag gcc tgg aac cga ctg cac     2256
 Ser Val His Gly Leu Pro Ser Pro His Glu Ala Trp Asn Arg Leu His
             740                 745                 750

 cgg gca ccg ccc tcc ttc ccg gct ccg ccc ccg tgg ccc aag tcc gtg     2304
 Arg Ala Pro Pro Ser Phe Pro Ala Pro Pro Pro Trp Pro Lys Ser Val
         755                 760                 765

 gac gcg gag cgg gtg tca gcc ctg acc aac cat gac cga gag ccg gac     2352
 Asp Ala Glu Arg Val Ser Ala Leu Thr Asn His Asp Arg Glu Pro Asp
     770                 775                 780

 aat ggc aag gag gag cag gaa cgg gac ctc ctg gag aag acg cgc ctg     2400
 Asn Gly Lys Glu Glu Gln Glu Arg Asp Leu Leu Glu Lys Thr Arg Leu
 785                 790                 795                 800

 ctg agc cgg gcc tcg ccc gcc acc ccc gct ggc cac ccc gtc agc ggc     2448
 Leu Ser Arg Ala Ser Pro Ala Thr Pro Ala Gly His Pro Val Ser Gly
                 805                 810                 815

 ctc ctg ctc cgg gcc cag agc gag ctg ggc cgg tcc ggg gcc ccc gcg     2496
 Leu Leu Leu Arg Ala Gln Ser Glu Leu Gly Arg Ser Gly Ala Pro Ala
             820                 825                 830

 gag cgg gag gcc gaa cct cgg gtc aag gag agc cgc tcc ccg gcc aag     2544
 Glu Arg Glu Ala Glu Pro Arg Val Lys Glu Ser Arg Ser Pro Ala Lys
         835                 840                 845

 gag gag gtc gcc aag atg ccc gcg cgc gca tcc ccg ccc cac agc aag     2592
 Glu Glu Val Ala Lys Met Pro Ala Arg Ala Ser Pro Pro His Ser Lys
     850                 855                 860

 gcg gcc cct gga gac gtg aag gtc aag gag gag cgc ggg gag gac gag     2640
 Ala Ala Pro Gly Asp Val Lys Val Lys Glu Glu Arg Gly Glu Asp Glu
 865                 870                 875                 880

 gcc tcc gag ccc ccg gcg ggc ggc ctg cac ccc gcg ccc ctg cag ctc     2688
 Ala Ser Glu Pro Pro Ala Gly Gly Leu His Pro Ala Pro Leu Gln Leu
                 885                 890                 895

 ggc ctg ggc cgc gag cgc ctg ggc gcg ccg ggc ttc gcg tgg gag cct     2736
 Gly Leu Gly Arg Glu Arg Leu Gly Ala Pro Gly Phe Ala Trp Glu Pro
             900                 905                 910

 ttc cgc ggc ctg gag ctg cca cgt cgc gcc ttc ccc gct gcc gcc ccc     2784
 Phe Arg Gly Leu Glu Leu Pro Arg Arg Ala Phe Pro Ala Ala Ala Pro
         915                 920                 925

 gcc ccg ggc tcc gcc gcc ctc ttg gag ccc ccg gag cgc ccc tac cgc     2832
 Ala Pro Gly Ser Ala Ala Leu Leu Glu Pro Pro Glu Arg Pro Tyr Arg
     930                 935                 940

 gac cgc gag ccc cac ggc tac agc ccc gag cgc ctg cgc ggg gag ctg     2880
 Asp Arg Glu Pro His Gly Tyr Ser Pro Glu Arg Leu Arg Gly Glu Leu
 945                 950                 955                 960

 gag cgc gcg cgg gcc ccg cac ctg ccg ccc gcc gcc ccc gcc ttg gac     2928
 Glu Arg Ala Arg Ala Pro His Leu Pro Pro Ala Ala Pro Ala Leu Asp
                 965                 970                 975

 ggc gcg ctg ctg ccc tcg ctg gga gcc ctg cac ttc ccg cgc ctc tcg     2976
 Gly Ala Leu Leu Pro Ser Leu Gly Ala Leu His Phe Pro Arg Leu Ser
             980                 985                 990

 ccc gcc gcg ctg cac aat ggg ctc ctg gcg cgg acc ccg ccc gcc gcc     3024
 Pro Ala Ala Leu His Asn Gly Leu Leu Ala Arg Thr Pro Pro Ala Ala
         995                1000                1005

 gcc gcc ctc ggc gca ccg ccc ccc ctg gtg acg gcg gcc ggg ccc ccc     3072
 Ala Ala Leu Gly Ala Pro Pro Pro Leu Val Thr Ala Ala Gly Pro Pro
    1010                1015                1020

 acg ccc ccc ggg ccg ccg cgg agc cgg act act ccg ctg ggg ggc ctc     3120
 Thr Pro Pro Gly Pro Pro Arg Ser Arg Thr Thr Pro Leu Gly Gly Leu
1025                1030                1035                1040

 ggg ccg ggc gag gcg cgc gac tac tcc ccg tcc cga aat ccc ccg gag     3168
 Gly Pro Gly Glu Ala Arg Asp Tyr Ser Pro Ser Arg Asn Pro Pro Glu
                1045                1050                1055

 gtg gag gcg cgg tag ccccggggcc gcagacgcct ctccgagcgg agcgcaaccc     3223
 Val Glu Ala Arg 
            1060

 gctgtccgtc tctccatcag ttcctagaac tcaagcacag ctcccgccga tcctggggcg   3283

 gcgccgcctc tccacccgca gcctgcggag gcggggactt gggtgtcggc ttttctgagg   3343

 gtgatctttt gttttccgag tttgggattc ggctgttggg aaaaaaaaat cgcgtttgta   3403

 ccttttcccc ccacagatga gaagtgtttg taatggattt gtatttttct taattttatg   3463

 ctctttagac gtttaaaaga accaaaaaag aaacttttgc ttcttcgttt tcggttggga   3523

 tttgcagttt aatggcctca gatccttctc cagatcccca gggtttcttt gtcttattta   3583

 tggagaaaaa ccggtcactt tgtccagcgc actgtgaggc ccccactcag gccagccctg   3643

 gccccccctt ggtacttgga accgaagtta cagattatat taaaataata atgtacaaaa   3703

 ctttgttttt ttgccttatt atgcagaagt gtaatttctt ttttggtttg tttttttaaa   3763

 agcaaacgaa acgtgtaaat agtctgttga tataaatata tgacgttact aaattcttaa   3823

 tctagataga ctttataaaa accgtttcca gaaacccctc tggttgtttg tctaacatgg   3883

 tcacaaaaac ccaggcgctg ctggctgtaa acattatcag aagtttaatg gcagcaactt   3943

 tccttcaact atgcaagcgc ttcccggcgg ctctgctggt tgggggagga aggttccgcc   4003

 agcgacctcc cagcccctgg gtccgtggag gggttgggtc cccccagcag agcccctggg   4063

 ccagcagaac agcactcctg ggcggctcct gtgggcttca ggactggccg gctccagccg   4123

 caagggcgat gctgtggacg tttgtgtgga tggtgcagtg ttcttggaat ctgtagacca   4183

 gatcggtgga ggtatagaag tgcaagagtc taaaggctga ttacacacac acacacacac   4243

 acacacaaaa tcactgctgt gtgttttctt ccgcctgagg catcagcgtc acctcggtgt   4303

 ggtcgtcgcc tcccaggccc ttggcctggc ctcctctcag tttgggtttt gccctcaccc   4363

 acatgagccc ccccatgccc tgcccccctt gcggcctttt gtgttccccg atgtctgggc   4423

 tgtgtccctg ccgggattcc cagccttcgg ggtcagccgt cgagccactt gctttgctca   4483

 gttctgtgtt tcagccacat ttccacggtg gaccctgttt gttttaaata ttctgttccc   4543

 atgtcaatca gtgacgataa atacagcctt gatttggatg aaaaaaaaaa aaagaatgaa   4603

 acacacacag cacacatacc acccacccat acacaaccga caccgacaga ccacagagac   4663

 aaaagaaaga ccagacgagc aggggacgcc cacagtggcg cgcgggcgag caaaaaaaag   4723

 cgcagcacaa caaccggagc agacacgacg acagaagcac ggccccaacg ccgagcccac   4783

 actgcgcgga acacagacgg cggagaacaa accgggggcc accaccagta gcgagccgca   4843

 aacacacagc aaagacgggg gcacccgcga gag                                4876




      <210> 18
      <211> 978
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (368)..(805)

      <220>
      <221> misc_feature
      <222> (1)...(978)
      <223> n = a,t,c or g

      <400> 18
 gatgtgtnaa actgaggact gacgactgtg cgaccggncc ggaattcccg ggtcgaccca     60

 cgcgtccgcg gggcgcgccc ggaaacccca aggcccagac ggctctcaga tccggggact    120

 gcggataaat ggccttaggc cgcgggcagc gagatgttgc gttccggtgt gggtgtgggt    180

 gtgcctccga cggcgtttcg gtgccagtgt cgaggttctt tctgcttagc tacccggagc    240

 cgactacgga ggaggacacc tgagtttacg tctcttccat ctgctgctcg cctcagctgc    300

 ctgggtcccc gacgagagcc aggtgacact taactccgcc atctgcgttt tgagcactgt    360

 tctcata  atg gag ttt cct gat ttg ggg aag cat tgt tca gaa aag act     409
          Met Glu Phe Pro Asp Leu Gly Lys His Cys Ser Glu Lys Thr
            1               5                  10

 tgc aag cag cta gat ttt ctt cca gta aaa tgt gat gca tgt aaa caa      457
 Cys Lys Gln Leu Asp Phe Leu Pro Val Lys Cys Asp Ala Cys Lys Gln
  15                  20                  25                  30

 gat ttc tgt aaa gat cat ttt cca tac gct gca cat aag tgt ccg ttt      505
 Asp Phe Cys Lys Asp His Phe Pro Tyr Ala Ala His Lys Cys Pro Phe
                  35                  40                  45

 gca ttc cag aag gat gtg cac gtc cca gta tgc cca ctc tgt aat acc      553
 Ala Phe Gln Lys Asp Val His Val Pro Val Cys Pro Leu Cys Asn Thr
              50                  55                  60

 ccc atc cca gta aaa aag ggc cag ata cca gac gtg gtg gtt ggt gat      601
 Pro Ile Pro Val Lys Lys Gly Gln Ile Pro Asp Val Val Val Gly Asp
          65                  70                  75

 cac att gac aga gac tgt gac tct cac cct ggg aag aag aaa gag aag      649
 His Ile Asp Arg Asp Cys Asp Ser His Pro Gly Lys Lys Lys Glu Lys
      80                  85                  90

 att ttt aca tac cgt tgc tca aaa gag ggc tgc aag aag aaa gag atg      697
 Ile Phe Thr Tyr Arg Cys Ser Lys Glu Gly Cys Lys Lys Lys Glu Met
  95                 100                 105                 110

 ctg cag atg gta tgt gcc caa tgt cac ggc aac ttc tgt atc cag cac      745
 Leu Gln Met Val Cys Ala Gln Cys His Gly Asn Phe Cys Ile Gln His
                 115                 120                 125

 aga cac cct ttg gac cac agc tgc aga cac ggg agt cgc ccc acc atc      793
 Arg His Pro Leu Asp His Ser Cys Arg His Gly Ser Arg Pro Thr Ile
             130                 135                 140

 aaa gct ggg tga gaa gagactccgc tgcgatggct cggagcacgc agtagcatgc      848
 Lys Ala Gly 
         145

 gtggaagcag cttacactct agtgggaagt ggagccccat tgagcaccat cccacactgg    908

 ctgctgatct tgtttgttga gggagatggg actataataa aattgaatgc tgaagttgaa    968

 aaaaaaaaaa                                                           978




      <210> 19
      <211> 2880
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (227)..(1438)

      <400> 19
 gtcttcacca tcattacgcc aagcttggca cgagggcgcc ccagcgcatc gctccctact     60

 ccgcctctcg ggatccttta agaggcgggg cttggctgcc agctccgcgg cccgggcaaa    120

 aggctgggac tttactccgg gtggcggcga ggacgagtct gtgctccatc agctgccgca    180

 cccgccgcct cccgccccca aaccccatcc ccgcggttga gccacg   atg agc ggc     235
                                                      Met Ser Gly
                                                        1

 aga gtc ggc gat ctg agc ccc agg cag aag gag gca ttg gcc aag ttt      283
 Arg Val Gly Asp Leu Ser Pro Arg Gln Lys Glu Ala Leu Ala Lys Phe
       5                  10                  15

 cgg gag aat gtc cag gat gtg ctg ccg gcc ctg ccg aat cca gat gac      331
 Arg Glu Asn Val Gln Asp Val Leu Pro Ala Leu Pro Asn Pro Asp Asp
  20                  25                  30                  35

 tat ttt ctc ctg cgt tgg ctc cga gcc aga agc ttc gac ctg cag aag      379
 Tyr Phe Leu Leu Arg Trp Leu Arg Ala Arg Ser Phe Asp Leu Gln Lys
                  40                  45                  50

 tcg gag gcc atg ctc cgg aag cat gtg gag ttc cga aag caa aag gac      427
 Ser Glu Ala Met Leu Arg Lys His Val Glu Phe Arg Lys Gln Lys Asp
              55                  60                  65

 att gac aac atc att agc tgg cag cct cca gag gtg atc caa cag tat      475
 Ile Asp Asn Ile Ile Ser Trp Gln Pro Pro Glu Val Ile Gln Gln Tyr
          70                  75                  80

 ctg tca ggg ggt atg tgt ggc tat gac ctg gat ggc tgc cca gtc tgg      523
 Leu Ser Gly Gly Met Cys Gly Tyr Asp Leu Asp Gly Cys Pro Val Trp
      85                  90                  95

 tac gac ata att gga cct ctg gat gcc aag ggt ctg ctg ttc tca gcc      571
 Tyr Asp Ile Ile Gly Pro Leu Asp Ala Lys Gly Leu Leu Phe Ser Ala
 100                 105                 110                 115

 tcc aaa cag gac ctg ctg agg acc aag atg cgg gag tgt gag ctg ctt      619
 Ser Lys Gln Asp Leu Leu Arg Thr Lys Met Arg Glu Cys Glu Leu Leu
                 120                 125                 130

 ctg caa gag tgt gcc cac cag acc aca aag ttg ggg agg aag gtg gag      667
 Leu Gln Glu Cys Ala His Gln Thr Thr Lys Leu Gly Arg Lys Val Glu
             135                 140                 145

 acc atc acc ata att tat gac tgc gag ggg ctt ggc ctc aag cat ctc      715
 Thr Ile Thr Ile Ile Tyr Asp Cys Glu Gly Leu Gly Leu Lys His Leu
         150                 155                 160

 tgg aag cct gct gtg gag gcc tat gga gag ttt ctc tgc atg ttt gag      763
 Trp Lys Pro Ala Val Glu Ala Tyr Gly Glu Phe Leu Cys Met Phe Glu
     165                 170                 175

 gaa aat tat ccc gaa aca ctg aag cgt ctt ttt gtt gtt aaa gcc ccc      811
 Glu Asn Tyr Pro Glu Thr Leu Lys Arg Leu Phe Val Val Lys Ala Pro
 180                 185                 190                 195

 aaa ctg ttt cct gtg gcc tat aac ctc atc aaa ccc ttc ctg agt gag      859
 Lys Leu Phe Pro Val Ala Tyr Asn Leu Ile Lys Pro Phe Leu Ser Glu
                 200                 205                 210

 gac act cgt aag aag atc atg gtc ctg gga gca aat tgg aag gag gtt      907
 Asp Thr Arg Lys Lys Ile Met Val Leu Gly Ala Asn Trp Lys Glu Val
             215                 220                 225

 tta ctg aaa cat atc agc cct gac cag gtg cct gtg gag tat ggg ggc      955
 Leu Leu Lys His Ile Ser Pro Asp Gln Val Pro Val Glu Tyr Gly Gly
         230                 235                 240

 acc atg act gac cct gat gga aac ccc aag tgc aaa tcc aag atc aac     1003
 Thr Met Thr Asp Pro Asp Gly Asn Pro Lys Cys Lys Ser Lys Ile Asn
     245                 250                 255

 tac ggg ggt gac atc ccc agg aag tat tat gtg cga gac cag gtg aaa     1051
 Tyr Gly Gly Asp Ile Pro Arg Lys Tyr Tyr Val Arg Asp Gln Val Lys
 260                 265                 270                 275

 cag cag tat gaa cac agc gtg cag att tcc cgt ggc tcc tcc cac caa     1099
 Gln Gln Tyr Glu His Ser Val Gln Ile Ser Arg Gly Ser Ser His Gln
                 280                 285                 290

 gtg gag tat gag atc ctc ttc cct ggc tgt gtc ctc agg tgg cag ttt     1147
 Val Glu Tyr Glu Ile Leu Phe Pro Gly Cys Val Leu Arg Trp Gln Phe
             295                 300                 305

 atg tca gat gga gcg gat gtt ggt ttt ggg att ttc ctg aag acc aag     1195
 Met Ser Asp Gly Ala Asp Val Gly Phe Gly Ile Phe Leu Lys Thr Lys
         310                 315                 320

 atg gga gag agg cag cgg gca ggg gag atg aca gag gtg ctg ccc aac     1243
 Met Gly Glu Arg Gln Arg Ala Gly Glu Met Thr Glu Val Leu Pro Asn
     325                 330                 335

 cag agg tac aac tcc cac ctg gtc cct gaa gat ggg acc ctc acc tgc     1291
 Gln Arg Tyr Asn Ser His Leu Val Pro Glu Asp Gly Thr Leu Thr Cys
 340                 345                 350                 355

 agt gat cct ggc atc tat gtc ctg cgg ttt gac aac acc tac agc ttc     1339
 Ser Asp Pro Gly Ile Tyr Val Leu Arg Phe Asp Asn Thr Tyr Ser Phe
                 360                 365                 370

 att cat gcc aag aag gtc aat ttc act gtg gag gtc ctg ctt cca gac     1387
 Ile His Ala Lys Lys Val Asn Phe Thr Val Glu Val Leu Leu Pro Asp
             375                 380                 385

 aaa gcc tca gaa gag aag atg aaa cag ctg ggg gca ggc acc ccg aaa     1435
 Lys Ala Ser Glu Glu Lys Met Lys Gln Leu Gly Ala Gly Thr Pro Lys
         390                 395                 400

 taa cacc ttctcctata gcaggcctgg ccccctcagt gtctccctgt caatttctac     1492
 


 cccttgtagc agtcattttc gcacaaccct gaagcccaaa gaaactgggc tggaggacag   1552

 acctcaggag ctttcatttc agttaggcag aggaagagcg actgcagtgg gtctccgtgt   1612

 ctatcaaata cctaaggagt ccccaggagc tggctggcca tcgtgatagg atctgtctgt   1672

 cctgtaaact gtgccaactt cacctgtcca gggacagcga agctgggggt ggcggggggc   1732

 atgtaccaca gggtggcagc agggaaaaaa attagaaaag ggtgaaagat tgggacttaa   1792

 cacttcaggg aagtcagctg ccggggagaa acttgctcct aaatgaacac ataagtttag   1852

 atcgcaatga ggagtagcag ggtagctggt tgctagagtt acggtgggga tcagaaactc   1912

 ttccaaacat tttagcactg aggctggggt agcttttggc ttttcccagg tctcaggagg   1972

 tggcctgagt cagcacacat cttcccactc ggtagacagg ctggcctctc cctcactttg   2032

 agactttggc aactcctggg ccacacggcc tgcctctttg attactaatg attgtcagtg   2092

 actcagagct tcctgggact tcgggtaccc acccgctgtt ctccatgcaa acaaagcgcc   2152

 agggaaatga cccacaggga tcgcagctgc agggagggcc agggaggttg ggggtgggag   2212

 tgaatgctaa aagcagatcg tccagtgccc ttttcagtgc taccggcctc tcaccaagca   2272

 gtcctccatg tgagcaaccc cgagacaaaa atgctaagtg ggatcaagag agcagcactc   2332

 ggagagggtg tttgccagtc tgagtgtccc gcggtgcccg ccaacccgct tcctgactga   2392

 cctgagcaag gtcttactaa gcagtcccat ctctgtggga ggcatgcaac gcgtgcaggg   2452

 agttcaggtg ccggtcggcg tagccaggcc tggaggcccc ccaggcagga ggccgcccaa   2512

 aggcggggcc ggcgtctcgc agactagggg ctgggggcgg ccacagacgg cctcgaaacc   2572

 acagccctta ccccaatccc acgagccccg ccaacgaacc acaggtgctg ggctttagag   2632

 aacatgggaa ggcggcccca gacctggcgg gaacgccttt ccctcagagc caggccccgg   2692

 ccccgtctgg gaagctcatc ttgcgaagct gagggagctc agggcaaagg ccaggctagc   2752

 gcggaccgga aggggccgag gctgcacggg cctctgccag aacgctcagg acatcccggc   2812

 ctgggtttac aacgctgtta ggaaaattaa ccaatgaata aagcaacgtt cagtgcgcaa   2872

 aaaaaaaa                                                            2880




      <210> 20
      <211> 1230
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(1010)

      <400> 20
 tctgagctac agagggggac    atg gcg tgt aga ggc tgg gcg cag aga ggc      50
                          Met Ala Cys Arg Gly Trp Ala Gln Arg Gly
                            1               5                  10

 tgg ggc tgc ggc cag gcg tgg ggt gcg tcg gtg ggc ggc cgc agc tgc       98
 Trp Gly Cys Gly Gln Ala Trp Gly Ala Ser Val Gly Gly Arg Ser Cys
                  15                  20                  25

 gag gag ctc act gcg gtc cta acc ccg ccg cag ctc ctc gga cgc agg      146
 Glu Glu Leu Thr Ala Val Leu Thr Pro Pro Gln Leu Leu Gly Arg Arg
              30                  35                  40

 ttt aac ttc ttt att caa caa aaa tgc gga ttc aga aaa gca ccc agg      194
 Phe Asn Phe Phe Ile Gln Gln Lys Cys Gly Phe Arg Lys Ala Pro Arg
          45                  50                  55

 aag gtt gaa cct cga aga tca gac cca ggg aca agt ggt gaa gca tac      242
 Lys Val Glu Pro Arg Arg Ser Asp Pro Gly Thr Ser Gly Glu Ala Tyr
      60                  65                  70

 aag aga agt gct ttg att cct cct gtg gaa gaa aca gtc ttt tat cct      290
 Lys Arg Ser Ala Leu Ile Pro Pro Val Glu Glu Thr Val Phe Tyr Pro
  75                  80                  85                  90

 tct ccc tat cct ata agg agt ctc ata aaa cct tta ttt ttt act gtt      338
 Ser Pro Tyr Pro Ile Arg Ser Leu Ile Lys Pro Leu Phe Phe Thr Val
                  95                 100                 105

 ggg ttt aca ggc tgt gca ttt gga tca gct gct att tgg caa tat gaa      386
 Gly Phe Thr Gly Cys Ala Phe Gly Ser Ala Ala Ile Trp Gln Tyr Glu
             110                 115                 120

 tca ctg aaa tcc agg gtc cag agt tat ttt gat ggt ata aaa gct gat      434
 Ser Leu Lys Ser Arg Val Gln Ser Tyr Phe Asp Gly Ile Lys Ala Asp
         125                 130                 135

 tgg ttg gat agc ata aga cca caa aaa gaa gga gac ttc aga aag gag      482
 Trp Leu Asp Ser Ile Arg Pro Gln Lys Glu Gly Asp Phe Arg Lys Glu
     140                 145                 150

 att aac aag tgg tgg aat aac cta agt gat ggc cag cgg act gtg aca      530
 Ile Asn Lys Trp Trp Asn Asn Leu Ser Asp Gly Gln Arg Thr Val Thr
 155                 160                 165                 170

 ggt att ata gct gca aat gtc ctt gta ttc tgt tta tgg aga gta cct      578
 Gly Ile Ile Ala Ala Asn Val Leu Val Phe Cys Leu Trp Arg Val Pro
                 175                 180                 185

 tct ctg cag cgg aca atg atc aga tat ttc aca tcg aat cca gcc tca      626
 Ser Leu Gln Arg Thr Met Ile Arg Tyr Phe Thr Ser Asn Pro Ala Ser
             190                 195                 200

 agt gtt att tcc aat ttt gtc agt tac gtg ggt aaa gtt gcc aca gga      674
 Ser Val Ile Ser Asn Phe Val Ser Tyr Val Gly Lys Val Ala Thr Gly
         205                 210                 215

 aga tat gga cca tca ctt ggt gca tct ggt gcc atc atg aca gtc ctc      722
 Arg Tyr Gly Pro Ser Leu Gly Ala Ser Gly Ala Ile Met Thr Val Leu
     220                 225                 230

 gca gct gtc tgc act aag atc cca gaa ggg agg ctt gcc att att ttc      770
 Ala Ala Val Cys Thr Lys Ile Pro Glu Gly Arg Leu Ala Ile Ile Phe
 235                 240                 245                 250

 ctt ccg atg ttc acg ttc aca gca ggg aat gcc ctg aaa gcc att atc      818
 Leu Pro Met Phe Thr Phe Thr Ala Gly Asn Ala Leu Lys Ala Ile Ile
                 255                 260                 265

 gcc atg gat aca gca gga atg atc ctg gga tgg aaa ttt ttt gat cat      866
 Ala Met Asp Thr Ala Gly Met Ile Leu Gly Trp Lys Phe Phe Asp His
             270                 275                 280

 gcg gca cat ctt ggg gga gct ctt ttt gga ata tgg tat gtt act tac      914
 Ala Ala His Leu Gly Gly Ala Leu Phe Gly Ile Trp Tyr Val Thr Tyr
         285                 290                 295

 ggt cat gaa ctg att tgg aag aac agg gag ccg cta gtg aaa atc tgg      962
 Gly His Glu Leu Ile Trp Lys Asn Arg Glu Pro Leu Val Lys Ile Trp
     300                 305                 310

 cat gaa ata agg act aat ggc ccc aaa aaa gga ggt ggc tct aag taa     1010
 His Glu Ile Arg Thr Asn Gly Pro Lys Lys Gly Gly Gly Ser Lys 
 315                 320                 325

 aactgggatt ggacagtagt ggtgcatctg gtccttgccg cctgagagcc ccaggagaca   1070

 tcggctagag tgaccatggc tatgctcccg tctggaagat gccagcatct ggcctcccac   1130

 tgttttcagc tgtgtccccc agtccgtgtc tttttagaat gtgaatgatg ataaagttgt   1190

 gaaataaagg tttctatcta gtttgtaaaa aaaaaaaaaa                         1230




      <210> 21
      <211> 3568
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2940)

      <400> 21
  atg agg ggt tac cat ggc gac cga ggc agc cat ccc cgc cca gcc cgc      48
  Met Arg Gly Tyr His Gly Asp Arg Gly Ser His Pro Arg Pro Ala Arg
    1               5                  10                  15

 ttt gct gac caa cag cat atg gac gtg ggc cct gct gcc agg gcc cca       96
 Phe Ala Asp Gln Gln His Met Asp Val Gly Pro Ala Ala Arg Ala Pro
              20                  25                  30

 tac ctg ctg ggc tcc agg gag gcc ttc tcc acc gag ccc cgc ttc tgt      144
 Tyr Leu Leu Gly Ser Arg Glu Ala Phe Ser Thr Glu Pro Arg Phe Cys
          35                  40                  45

 gcc ccg aga gct ggc ctg gga cac att tct cct gaa ggg ccc ctg agc      192
 Ala Pro Arg Ala Gly Leu Gly His Ile Ser Pro Glu Gly Pro Leu Ser
      50                  55                  60

 ctg agt gag ggg ccg tcg gta ggc cct gag gga ggg cca gcg ggg gcc      240
 Leu Ser Glu Gly Pro Ser Val Gly Pro Glu Gly Gly Pro Ala Gly Ala
  65                  70                  75                  80

 ggg gtt ggg ggg ggt agc agc acc ttc ccc agg atg tac cct ggc cag      288
 Gly Val Gly Gly Gly Ser Ser Thr Phe Pro Arg Met Tyr Pro Gly Gln
                  85                  90                  95

 ggc ccc ttc gac acc tgt gaa gac tgt gtg ggc cac cca cag ggc aag      336
 Gly Pro Phe Asp Thr Cys Glu Asp Cys Val Gly His Pro Gln Gly Lys
             100                 105                 110

 ggt gcc ccc cgc ctg cct cct aca ctc ctg gat cag ttt gaa aag cag      384
 Gly Ala Pro Arg Leu Pro Pro Thr Leu Leu Asp Gln Phe Glu Lys Gln
         115                 120                 125

 ttg cca gtt caa caa gat ggc ttc cac aca cta cca tac cag cga ggg      432
 Leu Pro Val Gln Gln Asp Gly Phe His Thr Leu Pro Tyr Gln Arg Gly
     130                 135                 140

 cca gca ggg gca ggg ccc ggg cca gcg cca ggg acg ggc act gcc cca      480
 Pro Ala Gly Ala Gly Pro Gly Pro Ala Pro Gly Thr Gly Thr Ala Pro
 145                 150                 155                 160

 gag ccc cgc agt gag agc cct agc cgc atc cgg cac ctg gtt cat tct      528
 Glu Pro Arg Ser Glu Ser Pro Ser Arg Ile Arg His Leu Val His Ser
                 165                 170                 175

 gtg cag aag ctc ttt gcc aag tcc cac tct ctg gag gcg ccg ggg aag      576
 Val Gln Lys Leu Phe Ala Lys Ser His Ser Leu Glu Ala Pro Gly Lys
             180                 185                 190

 cgg gac tat aat ggg ccc aag gct gag gga aga ggt ggc tct gga gga      624
 Arg Asp Tyr Asn Gly Pro Lys Ala Glu Gly Arg Gly Gly Ser Gly Gly
         195                 200                 205

 gac agc tac ccc ggc ccg ggc tct gga ggc ccc cac acc tcc cat cac      672
 Asp Ser Tyr Pro Gly Pro Gly Ser Gly Gly Pro His Thr Ser His His
     210                 215                 220

 cac cat cac cac cac cat cac cac cac cac cag tcc cgg cac ggc aag      720
 His His His His His His His His His His Gln Ser Arg His Gly Lys
 225                 230                 235                 240

 agg agc aag agc aag gac cgc aag ggg gat ggg cgg cac cag gcc aag      768
 Arg Ser Lys Ser Lys Asp Arg Lys Gly Asp Gly Arg His Gln Ala Lys
                 245                 250                 255

 tcc aca ggc tgg tgg agt tcc gat gac aac ttg gac agt gat agc ggc      816
 Ser Thr Gly Trp Trp Ser Ser Asp Asp Asn Leu Asp Ser Asp Ser Gly
             260                 265                 270

 ttc ctg gcg ggt ggg agg ccc cct ggg gag cct ggt ggt ccc ttc tgc      864
 Phe Leu Ala Gly Gly Arg Pro Pro Gly Glu Pro Gly Gly Pro Phe Cys
         275                 280                 285

 ctg gag ggt cca gat ggg tcc tac cgg gac ttg agc ttc aag ggg cgc      912
 Leu Glu Gly Pro Asp Gly Ser Tyr Arg Asp Leu Ser Phe Lys Gly Arg
     290                 295                 300

 tcg ggc ggg tcg gaa ggc cgc tgc ctt gcc tgc act ggc atg tcc atg      960
 Ser Gly Gly Ser Glu Gly Arg Cys Leu Ala Cys Thr Gly Met Ser Met
 305                 310                 315                 320

 tca ctg gat gga cag tcg gtc aag cga agt gcc tgg cat acc atg atg     1008
 Ser Leu Asp Gly Gln Ser Val Lys Arg Ser Ala Trp His Thr Met Met
                 325                 330                 335

 gtc agc cag ggc cgg gat gga tac ccg ggg gcc ggg cca ggc aag ggg     1056
 Val Ser Gln Gly Arg Asp Gly Tyr Pro Gly Ala Gly Pro Gly Lys Gly
             340                 345                 350

 ctc ctg ggt ccg gag acc aag gcc aaa gcc agg act tat cac tat ctg     1104
 Leu Leu Gly Pro Glu Thr Lys Ala Lys Ala Arg Thr Tyr His Tyr Leu
         355                 360                 365

 cag gtg ccg caa gat gac tgg ggg ggt tac ccc acc ggt ggc aag gat     1152
 Gln Val Pro Gln Asp Asp Trp Gly Gly Tyr Pro Thr Gly Gly Lys Asp
     370                 375                 380

 ggg gag atc ccc tgc cgc agg atg cgg agc ggc agc tac atc aaa gcc     1200
 Gly Glu Ile Pro Cys Arg Arg Met Arg Ser Gly Ser Tyr Ile Lys Ala
 385                 390                 395                 400

 atg ggg gat gag gag agc gga gac tca gac ggc agc ccc aag aca tct     1248
 Met Gly Asp Glu Glu Ser Gly Asp Ser Asp Gly Ser Pro Lys Thr Ser
                 405                 410                 415

 ccc aaa gca gtc gcc cga cgc ttc acc acc cgt cgc tcc tcc agc gtg     1296
 Pro Lys Ala Val Ala Arg Arg Phe Thr Thr Arg Arg Ser Ser Ser Val
             420                 425                 430

 gac cag gcc agg atc agc tgc tgt gtc cca ccc cgg atc cac ccc cgg     1344
 Asp Gln Ala Arg Ile Ser Cys Cys Val Pro Pro Arg Ile His Pro Arg
         435                 440                 445

 agc tcc atc cct ggc tac agc cgt tcc ctc acc act gga cag ctc agc     1392
 Ser Ser Ile Pro Gly Tyr Ser Arg Ser Leu Thr Thr Gly Gln Leu Ser
     450                 455                 460

 gat gag ttg aac cag cag ctg gag gcc gtg tgc ggg tcg gtg ttt ggg     1440
 Asp Glu Leu Asn Gln Gln Leu Glu Ala Val Cys Gly Ser Val Phe Gly
 465                 470                 475                 480

 gag ctg gag tcc cag gcc gtg gac gcc ctg gac ctg ccc ggc tgt ttc     1488
 Glu Leu Glu Ser Gln Ala Val Asp Ala Leu Asp Leu Pro Gly Cys Phe
                 485                 490                 495

 cgc atg cgg agc cac agc tac ctc cgg gcc atc cag gcc ggc tgc tct     1536
 Arg Met Arg Ser His Ser Tyr Leu Arg Ala Ile Gln Ala Gly Cys Ser
             500                 505                 510

 caa gac gac gac tgc ctg ccc ctc ctc gct acc cct gcc gct gtc tca     1584
 Gln Asp Asp Asp Cys Leu Pro Leu Leu Ala Thr Pro Ala Ala Val Ser
         515                 520                 525

 ggg agg ccc ggc tcc tcc ttc aac ttc aga aag gcc ccg ccc ccc atc     1632
 Gly Arg Pro Gly Ser Ser Phe Asn Phe Arg Lys Ala Pro Pro Pro Ile
     530                 535                 540

 ccg ccg gga agc cag gcc ccg ccc cgc atc tcc atc acc gcc cag agc     1680
 Pro Pro Gly Ser Gln Ala Pro Pro Arg Ile Ser Ile Thr Ala Gln Ser
 545                 550                 555                 560

 agc acc gac tcc gcg cac gag agc ttc acg gcg gcc gag ggc ccc gcc     1728
 Ser Thr Asp Ser Ala His Glu Ser Phe Thr Ala Ala Glu Gly Pro Ala
                 565                 570                 575

 cgg cgc tgc agc tcc gcc gac ggg ctg gac ggc ccc gcc atg ggt gcg     1776
 Arg Arg Cys Ser Ser Ala Asp Gly Leu Asp Gly Pro Ala Met Gly Ala
             580                 585                 590

 cgc aca ctg gag ttg gcg ccg gtg ccg ccc cgg gcc agc ccc aag ccc     1824
 Arg Thr Leu Glu Leu Ala Pro Val Pro Pro Arg Ala Ser Pro Lys Pro
         595                 600                 605

 ccc aca ctc atc atc aag acc atc cct ggc agg gag gag ctg cgg agc     1872
 Pro Thr Leu Ile Ile Lys Thr Ile Pro Gly Arg Glu Glu Leu Arg Ser
     610                 615                 620

 ctg gcg cgg cag cgg aag tgg cgg ccg tcc att ggg gtg cag gtg gag     1920
 Leu Ala Arg Gln Arg Lys Trp Arg Pro Ser Ile Gly Val Gln Val Glu
 625                 630                 635                 640

 acg atc tca gat tcg gac acc gag aac agg agc cgg agg gag ttc cac     1968
 Thr Ile Ser Asp Ser Asp Thr Glu Asn Arg Ser Arg Arg Glu Phe His
                 645                 650                 655

 tct att ggc gtg cag gtg gaa gag gac aag agg cga gca agg ttc aag     2016
 Ser Ile Gly Val Gln Val Glu Glu Asp Lys Arg Arg Ala Arg Phe Lys
             660                 665                 670

 cgc tcc aat agt gtg acg gct ggc gtg cag gca gac ctg gag ctg gag     2064
 Arg Ser Asn Ser Val Thr Ala Gly Val Gln Ala Asp Leu Glu Leu Glu
         675                 680                 685

 ggc ctg gca ggc ctg gcc acg gtg gcc aca gaa gac aag gcc ctg cag     2112
 Gly Leu Ala Gly Leu Ala Thr Val Ala Thr Glu Asp Lys Ala Leu Gln
     690                 695                 700

 ttt gga cgc tcc ttc cag agg cac gcc tct gag ccc cag cct ggg ccc     2160
 Phe Gly Arg Ser Phe Gln Arg His Ala Ser Glu Pro Gln Pro Gly Pro
 705                 710                 715                 720

 cgg gcc ccc acc tac tca gtc ttc cgc acg gtc cac acg cag ggc cag     2208
 Arg Ala Pro Thr Tyr Ser Val Phe Arg Thr Val His Thr Gln Gly Gln
                 725                 730                 735

 tgg gcc tac cgc gag ggc tac cca ctg ccg tac gag ccg ccg gcc acc     2256
 Trp Ala Tyr Arg Glu Gly Tyr Pro Leu Pro Tyr Glu Pro Pro Ala Thr
             740                 745                 750

 gat ggg tcg ccc ggc cct gcc ccc gcc ccc acc ccc tgc cct ggg gcc     2304
 Asp Gly Ser Pro Gly Pro Ala Pro Ala Pro Thr Pro Cys Pro Gly Ala
         755                 760                 765

 ggc cgc cgt gac tcc tgg ata gag cgc ggt tca cgt agc ctc ccc gac     2352
 Gly Arg Arg Asp Ser Trp Ile Glu Arg Gly Ser Arg Ser Leu Pro Asp
     770                 775                 780

 tca ggc cgc gca tcc ccc tgc cca cgc gac ggc gag tgg ttc atc aag     2400
 Ser Gly Arg Ala Ser Pro Cys Pro Arg Asp Gly Glu Trp Phe Ile Lys
 785                 790                 795                 800

 atg ctg cgg gca gag gtg gag aag ctg gag cac tgg tgc cag cag atg     2448
 Met Leu Arg Ala Glu Val Glu Lys Leu Glu His Trp Cys Gln Gln Met
                 805                 810                 815

 gag cgt gag gcg gag gac tat gag cta ccc gag gag atc ctg gag aag     2496
 Glu Arg Glu Ala Glu Asp Tyr Glu Leu Pro Glu Glu Ile Leu Glu Lys
             820                 825                 830

 atc cgc agt gct gtg ggc agc aca caa ctt ctc ctg tcc cag aag gtt     2544
 Ile Arg Ser Ala Val Gly Ser Thr Gln Leu Leu Leu Ser Gln Lys Val
         835                 840                 845

 cag cag ttc ttc cgg ctg tgt cag caa agc atg gat ccc act gcg ttc     2592
 Gln Gln Phe Phe Arg Leu Cys Gln Gln Ser Met Asp Pro Thr Ala Phe
     850                 855                 860

 cct gtg ccc acc ttc cag gac ctg gcg ggt ttc tgg gac ctc cta cag     2640
 Pro Val Pro Thr Phe Gln Asp Leu Ala Gly Phe Trp Asp Leu Leu Gln
 865                 870                 875                 880

 ctc tcc atc gag gat gtg acc ctc aag ttc ctg gag cta cag caa ctc     2688
 Leu Ser Ile Glu Asp Val Thr Leu Lys Phe Leu Glu Leu Gln Gln Leu
                 885                 890                 895

 aag gcc aac agc tgg aaa ctc ctg gag cct aag gag gag aag aag gtc     2736
 Lys Ala Asn Ser Trp Lys Leu Leu Glu Pro Lys Glu Glu Lys Lys Val
             900                 905                 910

 cct ccg ccg ata cca aag aag ccc ctg cgg ggc cgg ggc gtg ccg gtg     2784
 Pro Pro Pro Ile Pro Lys Lys Pro Leu Arg Gly Arg Gly Val Pro Val
         915                 920                 925

 aag gag cgc tcc ctg gac tcc gtg gac cgg cag cgg cag gaa gcg cgc     2832
 Lys Glu Arg Ser Leu Asp Ser Val Asp Arg Gln Arg Gln Glu Ala Arg
     930                 935                 940

 aag cgg ctc ctg gcg gcc aag cgc gcc gct tcc ttc cgc cac agc tcg     2880
 Lys Arg Leu Leu Ala Ala Lys Arg Ala Ala Ser Phe Arg His Ser Ser
 945                 950                 955                 960

 gcc acc gag agc gcc gac agc atc gag att tac atc ccc gag gcc cag     2928
 Ala Thr Glu Ser Ala Asp Ser Ile Glu Ile Tyr Ile Pro Glu Ala Gln
                 965                 970                 975

 acc agg ctg tga ccg gtccggcccg cccagcccgg cccgggcccg cggttctcca     2983
 Thr Arg Leu 


 cccgtactgt acacccagcg tcgaggtcac tgtgaacgcg ggccgccccg tgcgcccgcc   3043

 ccaccggcac cggacgcccc ggcccccggg cccgtcacac tctcgtgggt tttttacctt   3103

 cctgatccca cgcgaaggcg cccgggctgg gcagggggcc gtgcctctcc gccctgcgcc   3163

 cctcacctgg atcccctgcc cacctggtcc gacgctttgt ccccacctcc tccccatggg   3223

 caccatctct gccattcttt cccccacggg ccaggccggg ccgggtccct catctgggct   3283

 ctgcgtcccc ccctccccca ccccgcgggg ctgggcttcg tggggatcaa gcttcgtggc   3343

 tttttatgaa gaatcccgaa ccctgcctag gagcccgccc caccctccca ggggctccat   3403

 cctcagccct ctgcccactg ggcccaggga ccacagtggc tggaccaacc caggaccagg   3463

 gcgcctgggc ctctcccctt tcccagcggc tggggagggg agatgggggc ttcccctcac   3523

 cacacctgtg gctgttccca catccccttg aatatcccag gaaaa                   3568




      <210> 22
      <211> 1794
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (80)..(1456)

      <400> 22
 gctaccctgg ggctgatagt tcacctgtct caggaaccac ctgagcccac agatcctgtg     60

 ggcagcggcc agggcagcc atg gct tgg gca agt agg ctg ggc ctg ctg ctg     112
                      Met Ala Trp Ala Ser Arg Leu Gly Leu Leu Leu
                        1               5                  10

 gca ctg ctg ctg ccc gtg gtc ggt gcc tcc acg cca ggc acc gtg gtc      160
 Ala Leu Leu Leu Pro Val Val Gly Ala Ser Thr Pro Gly Thr Val Val
              15                  20                  25

 cga ctc aac aag gca gca ttg agc tac gtg tct gaa att ggg aaa gcc      208
 Arg Leu Asn Lys Ala Ala Leu Ser Tyr Val Ser Glu Ile Gly Lys Ala
          30                  35                  40

 cct ctc cag cgg gcc ctg cag gtc act gtc cct cat ttc ctg gac tgg      256
 Pro Leu Gln Arg Ala Leu Gln Val Thr Val Pro His Phe Leu Asp Trp
      45                  50                  55

 agt gga gag gcg ctt cag ccc acc agg atc cgg att ctg aat gtc cat      304
 Ser Gly Glu Ala Leu Gln Pro Thr Arg Ile Arg Ile Leu Asn Val His
  60                  65                  70                  75

 gtg ccc cgc ctc cac ctg aaa ttc att gct ggt ttc gga gtg cgc ctg      352
 Val Pro Arg Leu His Leu Lys Phe Ile Ala Gly Phe Gly Val Arg Leu
                  80                  85                  90

 ctg gca gca gct aat ttt act ttc aag gtc ttt cgc gcc cca gag ccc      400
 Leu Ala Ala Ala Asn Phe Thr Phe Lys Val Phe Arg Ala Pro Glu Pro
              95                 100                 105

 ctg gag ctg acg ctg cct gtg gaa ctg ctg gct gac acc cgc gtg acc      448
 Leu Glu Leu Thr Leu Pro Val Glu Leu Leu Ala Asp Thr Arg Val Thr
         110                 115                 120

 cag agc tcc atc agg acc cct gtg gtc agc atc tct gcc tgc tct tta      496
 Gln Ser Ser Ile Arg Thr Pro Val Val Ser Ile Ser Ala Cys Ser Leu
     125                 130                 135

 ttc tcg ggc cac gcc aac gag ttt gat ggc agt aac agc acc tcc cac      544
 Phe Ser Gly His Ala Asn Glu Phe Asp Gly Ser Asn Ser Thr Ser His
 140                 145                 150                 155

 gcg ctg ctg gtc ctg gtg cag aag cac att aaa gct gtc ttg agt aac      592
 Ala Leu Leu Val Leu Val Gln Lys His Ile Lys Ala Val Leu Ser Asn
                 160                 165                 170

 aag ctg tgc ctg agc acc tcc aac ctg gtg cag ggt gtc aat gtc cac      640
 Lys Leu Cys Leu Ser Thr Ser Asn Leu Val Gln Gly Val Asn Val His
             175                 180                 185

 ctg ggc acc tta att ggc ctc aac ccc gtg ggt cct gag tcc cag atc      688
 Leu Gly Thr Leu Ile Gly Leu Asn Pro Val Gly Pro Glu Ser Gln Ile
         190                 195                 200

 cgc tat tcc atg gtc agt gtg ccc act gtc acc agt gac tac att tcc      736
 Arg Tyr Ser Met Val Ser Val Pro Thr Val Thr Ser Asp Tyr Ile Ser
     205                 210                 215

 ctg gaa gtc aat gct gtt ctc ttc ctg ctg ggc aag ccc atc atc ctg      784
 Leu Glu Val Asn Ala Val Leu Phe Leu Leu Gly Lys Pro Ile Ile Leu
 220                 225                 230                 235

 ccc acg gat gcc acc cct ttt gtg ttg cca agg cat gtg ggt acc gag      832
 Pro Thr Asp Ala Thr Pro Phe Val Leu Pro Arg His Val Gly Thr Glu
                 240                 245                 250

 ggc tcc atg gcc acc gtg ggc ctc tcc cag cag ctg ttt gac tct gcg      880
 Gly Ser Met Ala Thr Val Gly Leu Ser Gln Gln Leu Phe Asp Ser Ala
             255                 260                 265

 ctc ctg ctg ctg cag aag gcc ggt gcc ctc aac ctg gac atc aca ggg      928
 Leu Leu Leu Leu Gln Lys Ala Gly Ala Leu Asn Leu Asp Ile Thr Gly
         270                 275                 280

 cag ctg agg tcg gat gac aac ctg ctg aac acc tct gct ctg ggc cgg      976
 Gln Leu Arg Ser Asp Asp Asn Leu Leu Asn Thr Ser Ala Leu Gly Arg
     285                 290                 295

 ctc atc ccg gag gtg gcc cgc cag ttt ccc gag ccc atg cct gtg gtg     1024
 Leu Ile Pro Glu Val Ala Arg Gln Phe Pro Glu Pro Met Pro Val Val
 300                 305                 310                 315

 ctc aag gtg cgg ctg ggt gcc aca cct gtg gcc atg ctc cac aca aac     1072
 Leu Lys Val Arg Leu Gly Ala Thr Pro Val Ala Met Leu His Thr Asn
                 320                 325                 330

 aac gcc acc ctg cgg ctg cag ccc ttc gtg gag gtc ctg gcc aca gcc     1120
 Asn Ala Thr Leu Arg Leu Gln Pro Phe Val Glu Val Leu Ala Thr Ala
             335                 340                 345

 tcc aac tcg gct ttc cag tcc ctc ttc tcc ctg gat gtg gta gtg aac     1168
 Ser Asn Ser Ala Phe Gln Ser Leu Phe Ser Leu Asp Val Val Val Asn
         350                 355                 360

 ttg aga ctc cag ctc tct gtg tcc aag gtg aag ctt cag ggg acc acg     1216
 Leu Arg Leu Gln Leu Ser Val Ser Lys Val Lys Leu Gln Gly Thr Thr
     365                 370                 375

 tct gtg ctg ggg gat gtc cag ctc acg gtg gcc tcc tcc aac gtg ggc     1264
 Ser Val Leu Gly Asp Val Gln Leu Thr Val Ala Ser Ser Asn Val Gly
 380                 385                 390                 395

 ttc att gat aca gat cag gtg cgc aca ctg atg ggc acc gtt ttt gag     1312
 Phe Ile Asp Thr Asp Gln Val Arg Thr Leu Met Gly Thr Val Phe Glu
                 400                 405                 410

 aag ccc ctg ctg gac cat ctc aat gct ctc ttg gcc atg gga att gcc     1360
 Lys Pro Leu Leu Asp His Leu Asn Ala Leu Leu Ala Met Gly Ile Ala
             415                 420                 425

 ctc cct ggt gtg gtc aac ctc cac tat gtt gcc cct gag atc ttt gtc     1408
 Leu Pro Gly Val Val Asn Leu His Tyr Val Ala Pro Glu Ile Phe Val
         430                 435                 440

 tat gag ggc tac gtg gtg ata tcc agt gga ctc ttc tac cag agc tga     1456
 Tyr Glu Gly Tyr Val Val Ile Ser Ser Gly Leu Phe Tyr Gln Ser 
     445                 450                 455

 ggcaagacca ctgggaggcc tgagagtggg ccagctcgct gctcaggcga atttctcatt   1516

 tcaagccact ggggaaactg aggcaaaacc atacttagtc atcaccaaca agctggactg   1576

 cttagctggg ctgttttatc ttccctgagt gcctgggtct ccctccctca cttctgccct   1636

 ttcccttcct cctcctcttc tcctccctct tccctcatct cccccctcct tcctctgccc   1696

 caccccaggg gggagcagac tgctcctcca ggctgtatag acctgccctc ttgcattaaa   1756

 caacttctct tgagctgcaa ctttcaaaaa aaaaaaaa                           1794




      <210> 23
      <211> 1437
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (17)..(1159)

      <400> 23
 cccatgcgct cgggcc    atg gcg cgc ctg ggc gct gtg cgc tcc cac tac      49
                      Met Ala Arg Leu Gly Ala Val Arg Ser His Tyr
                        1               5                  10

 tgc gcc ctg ctg ctg gcc gcg gcg ctg gcc gtc tgc gcc ttc tac tac       97
 Cys Ala Leu Leu Leu Ala Ala Ala Leu Ala Val Cys Ala Phe Tyr Tyr
              15                  20                  25

 ctc ggc tca ggc cgg gag acc ttc tcc agc gcc acc aag agg ctg aag      145
 Leu Gly Ser Gly Arg Glu Thr Phe Ser Ser Ala Thr Lys Arg Leu Lys
          30                  35                  40

 gag gcc cgc gcc ggg gct ccc gcc gcg ccc tcg ccg ccc gcg ctg gag      193
 Glu Ala Arg Ala Gly Ala Pro Ala Ala Pro Ser Pro Pro Ala Leu Glu
      45                  50                  55

 cta gcg cgg ggc tcc gtg gcg cca gcc ccc ggc gcg aag gcc aag agc      241
 Leu Ala Arg Gly Ser Val Ala Pro Ala Pro Gly Ala Lys Ala Lys Ser
  60                  65                  70                  75

 ttg gag ggc ggc ggt gcc ggg ccg gtg gac tac cac ctg ctg atg atg      289
 Leu Glu Gly Gly Gly Ala Gly Pro Val Asp Tyr His Leu Leu Met Met
                  80                  85                  90

 ttc acc aag gcg gag cac aat gcc gcg ctg cag gcc aag gcc cgc gtc      337
 Phe Thr Lys Ala Glu His Asn Ala Ala Leu Gln Ala Lys Ala Arg Val
              95                 100                 105

 gcg ctg cgc tca ctg ctg cgc ctc gcc aag ttc gag gcg cac gag gtg      385
 Ala Leu Arg Ser Leu Leu Arg Leu Ala Lys Phe Glu Ala His Glu Val
         110                 115                 120

 ctt aac ctt cac ttc gtg agc gag gag gcc agc cgc gag gtg gcc aag      433
 Leu Asn Leu His Phe Val Ser Glu Glu Ala Ser Arg Glu Val Ala Lys
     125                 130                 135

 ggc ctg ctg cgg gag ctc ctg ccg ccc gcc gct ggc ttc aag tgc aag      481
 Gly Leu Leu Arg Glu Leu Leu Pro Pro Ala Ala Gly Phe Lys Cys Lys
 140                 145                 150                 155

 gtc atc ttc cac gat gtt gct gtg ctg acg gat aag ctc ttc ccc atc      529
 Val Ile Phe His Asp Val Ala Val Leu Thr Asp Lys Leu Phe Pro Ile
                 160                 165                 170

 gtg gag gcc atg cag aag cac ttc agt gct ggc ttg gga acc tac tac      577
 Val Glu Ala Met Gln Lys His Phe Ser Ala Gly Leu Gly Thr Tyr Tyr
             175                 180                 185

 agt gac tcc atc ttc ttc ctc tcg gtc gcc atg cat cag atc atg ccc      625
 Ser Asp Ser Ile Phe Phe Leu Ser Val Ala Met His Gln Ile Met Pro
         190                 195                 200

 aaa gag atc ctg cag atc att cag ctg gac cta gac ctg aag ttt aag      673
 Lys Glu Ile Leu Gln Ile Ile Gln Leu Asp Leu Asp Leu Lys Phe Lys
     205                 210                 215

 acc aac atc cgg gag ttg ttt gag gaa ttt gac agt ttc ctg cca ggc      721
 Thr Asn Ile Arg Glu Leu Phe Glu Glu Phe Asp Ser Phe Leu Pro Gly
 220                 225                 230                 235

 gcc atc atc ggc ata gcc cgg gag atg cag cca gtt tac agg cac aca      769
 Ala Ile Ile Gly Ile Ala Arg Glu Met Gln Pro Val Tyr Arg His Thr
                 240                 245                 250

 ttc tgg cag ttc cgc cat gag aac ccc cag acc cgg gtt ggg ggc ccg      817
 Phe Trp Gln Phe Arg His Glu Asn Pro Gln Thr Arg Val Gly Gly Pro
             255                 260                 265

 ccc ccc gag ggg ctg ccg ggc ttc aac agc ggg gtg atg ttg ctg aac      865
 Pro Pro Glu Gly Leu Pro Gly Phe Asn Ser Gly Val Met Leu Leu Asn
         270                 275                 280

 ctg gag gcc atg cgc cag tcc ccg ctc tac agc cgc ctg ctg gag ccg      913
 Leu Glu Ala Met Arg Gln Ser Pro Leu Tyr Ser Arg Leu Leu Glu Pro
     285                 290                 295

 gcg cag gtg cag cag ctg gcc gac aag tac cac ttc cgc ggc cac ctc      961
 Ala Gln Val Gln Gln Leu Ala Asp Lys Tyr His Phe Arg Gly His Leu
 300                 305                 310                 315

 ggg gac cag gac ttc ttc acc atg atc ggc atg gag cac ccc aag ctc     1009
 Gly Asp Gln Asp Phe Phe Thr Met Ile Gly Met Glu His Pro Lys Leu
                 320                 325                 330

 ttc cat gtg ctg gac tgt acc tgg aac cgg cag ctg tgc acc tgg tgg     1057
 Phe His Val Leu Asp Cys Thr Trp Asn Arg Gln Leu Cys Thr Trp Trp
             335                 340                 345

 agg gac cat ggc tac agt gac gtc ttc gag gcc tat ttc agg tgt gag     1105
 Arg Asp His Gly Tyr Ser Asp Val Phe Glu Ala Tyr Phe Arg Cys Glu
         350                 355                 360

 ggc cac gtc aag atc tac cac ggg aac tgc aac act ccc atc ccg gag     1153
 Gly His Val Lys Ile Tyr His Gly Asn Cys Asn Thr Pro Ile Pro Glu
     365                 370                 375

 gac tag gcgctccccg tgccttgccc ccggggcctc cagatctggg ggaaggacag      1209
 Asp 
 380

 ggttccttgg gacagaccca agggcagtgt ctgacccgct agagagacac cgcagggaag   1269

 tcctgtgatt aaggtgctga gacctcctgg ccgggcaggt cactgtgctg aaggccaccc   1329

 gcaaggactt ggctgtgcac tgctggtgct tgggacctta ttcctccagg gagccaggcg   1389

 acacaaagga caccgctttc ccgtgggcct gggaagcaag ccttgaga                1437




      <210> 24
      <211> 2855
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (379)..(654)

      <400> 24
 ccgcaccacc cgctcccact cgggtcttct ccctttctct gagagctctg tggggagtgt     60

 gaaaccggag cgggatggag ctggcctcct ggagacactc atctccagga agcagggcag    120

 gccaacctaa ttccctagag ggccgaagag ggaaaggagg ggccctatgc ttggacaggc    180

 tcctcgcagc tcggttccac tttgtcctcc acagctgaga aggtgagctc cctgggcaag    240

 aactggcacc gcttctgcct gaaatgtgag cgctgccaca gcatcctgtc ccctggcggg    300

 catgcagagc acaatgggag gccatactgc cacaagccat gctatggggc tctctttgga    360

 cccaggggcc ctccccat  atg aag aca ttc act ggg gag acc tcg ctg tcc     411
                      Met Lys Thr Phe Thr Gly Glu Thr Ser Leu Ser
                        1               5                  10

 cct ggc tgt ggg gag ccc gtc tat ttt gct gag aag gtg atg tca tta      459
 Pro Gly Cys Gly Glu Pro Val Tyr Phe Ala Glu Lys Val Met Ser Leu
              15                  20                  25

 ggc aga aat tgg cac cga ccg tgt ctg agg tgc cag cgt tgc cac aag      507
 Gly Arg Asn Trp His Arg Pro Cys Leu Arg Cys Gln Arg Cys His Lys
          30                  35                  40

 acc ctg act gct ggg agt cat gct gag cat gat gga gtc ccc tac tgc      555
 Thr Leu Thr Ala Gly Ser His Ala Glu His Asp Gly Val Pro Tyr Cys
      45                  50                  55

 cac gtc ccc tgc tac ggc tac ctg ttt ggc ccc aaa ggt gtg aac act      603
 His Val Pro Cys Tyr Gly Tyr Leu Phe Gly Pro Lys Gly Val Asn Thr
  60                  65                  70                  75

 ggc gat gtg ggc tgc tac atc tat gac cca gtg aag ata aaa ttc aaa      651
 Gly Asp Val Gly Cys Tyr Ile Tyr Asp Pro Val Lys Ile Lys Phe Lys
                  80                  85                  90

 tga gacg ctcacaaaaa aggtcaccct aactcaggcc tcccatcatg cccctcatgg      708
 


 tccaatggaa gctacaaaaa tctccagtcc catgggggtt ggggaaggtg ggatcttggg    768

 ggcctgggcc taggctccat ggtaggccag agagtctaga ctttctctgc caattttttc    828

 cctttcccat ttctatctgg ttagggaaca gcccgttttg aagggtatcc tcctcctggc    888

 catcacaacc cctttcccca gcacattctg gagcttcaag gtactcataa aacttgtgtt    948

 tattgaattt cagcctctgt ggcttcttca ataaaatgtt ggctcccatg ccttcaactc   1008

 ttctttgggc atgagaccag tgggtggagg atggggagtt gggttggtac atgcattccc   1068

 tgcaggtgcc tcggaggtag cagggcctgc catgagaaca aaaagctctg ttctttttgt   1128

 cccttgggcc tggcattggc agtcctagca ccacacagtg gaacagcatg cccaccagcc   1188

 ccattggtac cagaagtctc atatgctagt cctttcttta gcaccatctc tctttctctc   1248

 cacgtcctgg atggtctctg gcagctgtgc ctgcctcgtc tctggcagca ggagggcggt   1308

 gccggcagcc agcagggcga tccccccata agtaagcttg ggcagtgaca gccacactcc   1368

 atctagcaag gccgccagtg gggccaaaga gccccccagc cggcccacca gtgcagtcag   1428

 ccccatccct gtctgtctga gcaccgtagg gtacaactct gaagtgaaca ggtaggcagt   1488

 ggtgaaggca gcttcagaaa aagctttccc catcactgcc aggacagtgc tccaggactt   1548

 catatcggag gacactagca gtctagtgcc gaacgccagg gccgtgccca gcagtgtccc   1608

 ggcttgcgtg aggcggcgtc ctgcgtagcg caccgacaag tagaccagca gcttggaggg   1668

 cagttccaca gccccgaaca acagctgtgc ctggtaaacg ttcagcccca gccccgacac   1728

 atccagactc aggccgtaat aggagaagtt cactccgaac cacaccacca cgcagcacag   1788

 tgagatgtgt cggagccgtg gtgtgcggaa caggtctagg tatgaaggtc ttcggaccac   1848

 ccgttccccg gcggccactt tgctcacagc ctcctggctg aagctgtcct cacacactgg   1908

 ccgcccattg agcctggcac agtggagcaa gtacctgtgg gcctctttca catggccttg   1968

 ggtcagaagc cagcgtgcag actcaggcac ccaccagagg ctgaggatgc ctggggcaca   2028

 aggcagggtg acagctagca gaagccatcg ccagtcccgt atcaggtacc caaccagtgc   2088

 cagcagcatc acgccccctg tccagaaggt gctgctcagg actccagcca cggtgcggtg   2148

 ctccacatcc agccactcca gctccagtgg catcacgatg atggtaaaac cagccagggc   2208

 tgagccagta agggtgcggg tgatggcaaa cattacatag ctgacggagg ctgcagatgc   2268

 caggcccagc accagggtac tcacgtaggc taccagcagc agacgccgcc gcccaaacct   2328

 gtcggacaga tatccaaagg ccacagcccc caccagcaca ccggcgaaga agaaagtgga   2388

 cgcagctctg ttcagacctt tctgctcaca caccagatcc cactgggact cagttgcaat   2448

 ggtagaggag aattctgagt ggtcgtactc ccagccctga gagcagggca ctgtggcagg   2508

 ttcatcctcc agctccccac ggctctgcct ttcttccccc aacgtggtgt tggggagagc   2568

 ctggggatag gcaaagcgga ggcaggagct gagcgtgcca tcaggctccc ggggaagatg   2628

 ggcctccagc cacacatcct gatggctgaa gttggcaggg gcacccggca gggcacatcg   2688

 gtgggcaggc acggcagcca ggaagatggg caggaggaag tgcagtggta gcagcactcg   2748

 gggcagggcc agcagtgcca cattccgcag ttggaagggc ccaaagccgc ccacctgctc   2808

 cagcagctcc tcaaagccca tgctgctcac ccaccaaaaa aaaaaaa                 2855




      <210> 25
      <211> 1717
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (292)..(1482)

      <400> 25
 cctgggggcg cggagagggc gcccaggttc accgcgctct cagcgcgcac ttccgggcac     60

 ggtcagggcg tgacgtcggg aggagggcag acacgccgct ttttggatgc ctcctatgcc    120

 tggcgggagt cttgtctgag ctggcaccac cacacggccc acgacatctt cgcagggaag    180

 cctgtggacc ctctgccagg ctccacaaga ggtcaggaca gtgcagtgtg ttcacaaggc    240

 cagtttctga tcgtccgccc cgaggctgag gaccagtagg cagctcccaa g atg ggt     297
                                                          Met Gly
                                                            1

 gaa agg aaa ggg gtc aac aag tac tat cct cca gac ttc aac cct gag      345
 Glu Arg Lys Gly Val Asn Lys Tyr Tyr Pro Pro Asp Phe Asn Pro Glu
           5                  10                  15

 aag cat ggc tct ctc aac cga tac cac aac agc cac ccg ctt cgg gag      393
 Lys His Gly Ser Leu Asn Arg Tyr His Asn Ser His Pro Leu Arg Glu
      20                  25                  30

 cgg gct cgg aag ctg tca cag ggc atc ctc atc atc cga ttc gaa atg      441
 Arg Ala Arg Lys Leu Ser Gln Gly Ile Leu Ile Ile Arg Phe Glu Met
  35                  40                  45                  50

 cca tat aac atc tgg tgc gat ggc tgc aag aac cac atc ggc atg ggt      489
 Pro Tyr Asn Ile Trp Cys Asp Gly Cys Lys Asn His Ile Gly Met Gly
                  55                  60                  65

 gtt cgt tac aat gca gaa aag aag aag gtg ggc aat tac tac aca acc      537
 Val Arg Tyr Asn Ala Glu Lys Lys Lys Val Gly Asn Tyr Tyr Thr Thr
              70                  75                  80

 ccg atc tac agg ttc cgg atg aaa tgc cac ctc tgt gtc aac tac atc      585
 Pro Ile Tyr Arg Phe Arg Met Lys Cys His Leu Cys Val Asn Tyr Ile
          85                  90                  95

 gag atg cag acg gac ccc gcc aac tgc gac tac gtg atc gtg agt ggc      633
 Glu Met Gln Thr Asp Pro Ala Asn Cys Asp Tyr Val Ile Val Ser Gly
     100                 105                 110

 gcc cag cgc aag gag gag cgc tgg gac atg gcg gac aat gag cag gtg      681
 Ala Gln Arg Lys Glu Glu Arg Trp Asp Met Ala Asp Asn Glu Gln Val
 115                 120                 125                 130

 ctg acc aca gag cat gag aag aag cag aag ctg gag acg gac gcc atg      729
 Leu Thr Thr Glu His Glu Lys Lys Gln Lys Leu Glu Thr Asp Ala Met
                 135                 140                 145

 ttc cgg ctg gag cat ggc gag gcc gac cgc agc aca ctc aag aag gcg      777
 Phe Arg Leu Glu His Gly Glu Ala Asp Arg Ser Thr Leu Lys Lys Ala
             150                 155                 160

 ctg ccc aca ctg agc cac atc cag gag gcc cag agc gcc tgg aag gac      825
 Leu Pro Thr Leu Ser His Ile Gln Glu Ala Gln Ser Ala Trp Lys Asp
         165                 170                 175

 gac ttc gcc ctc aac agc atg ctg cgg aga agg ttc cgg gaa aag aaa      873
 Asp Phe Ala Leu Asn Ser Met Leu Arg Arg Arg Phe Arg Glu Lys Lys
     180                 185                 190

 aaa gcc atc cag gag gag gag gag aga gac cag gcc ttg cag gcc aag      921
 Lys Ala Ile Gln Glu Glu Glu Glu Arg Asp Gln Ala Leu Gln Ala Lys
 195                 200                 205                 210

 gcg agc ctg acc atc ccg ctg gtg ccc gag acg gaa gat gac cgc aag      969
 Ala Ser Leu Thr Ile Pro Leu Val Pro Glu Thr Glu Asp Asp Arg Lys
                 215                 220                 225

 ctg gcg gct ctg ctg aag ttc cac acc ctg gac tcc tac gag gac aag     1017
 Leu Ala Ala Leu Leu Lys Phe His Thr Leu Asp Ser Tyr Glu Asp Lys
             230                 235                 240

 cag aaa ctc aag cgg acc gag atc atc agc cgc tcc tgg ttc ccc tct     1065
 Gln Lys Leu Lys Arg Thr Glu Ile Ile Ser Arg Ser Trp Phe Pro Ser
         245                 250                 255

 gcc ccc gga tcc gcc tcc agc agc aag gtc agc ggc gtc ctg aag aag     1113
 Ala Pro Gly Ser Ala Ser Ser Ser Lys Val Ser Gly Val Leu Lys Lys
     260                 265                 270

 ctg gca cag agc cgc aga acc gcg ctt gcc acc tcc ccc atc acc gtc     1161
 Leu Ala Gln Ser Arg Arg Thr Ala Leu Ala Thr Ser Pro Ile Thr Val
 275                 280                 285                 290

 ggg gac ctg ggc atc gtg cgg cgg agg tct cgg gac gtc ccg gag agc     1209
 Gly Asp Leu Gly Ile Val Arg Arg Arg Ser Arg Asp Val Pro Glu Ser
                 295                 300                 305

 ccc cag cat gcg gcc gac acc ccc aag tct ggg gaa ccg cgg gta cca     1257
 Pro Gln His Ala Ala Asp Thr Pro Lys Ser Gly Glu Pro Arg Val Pro
             310                 315                 320

 gag gag gct gcc cag gac cgg ccc atg tcc ccc gga gac tgt cct ccg     1305
 Glu Glu Ala Ala Gln Asp Arg Pro Met Ser Pro Gly Asp Cys Pro Pro
         325                 330                 335

 gaa aca act gag acc ccc aag tgc agc agc ccg agg ggg cag gaa ggg     1353
 Glu Thr Thr Glu Thr Pro Lys Cys Ser Ser Pro Arg Gly Gln Glu Gly
     340                 345                 350

 agc cgt cag gac aag ccc ctg tcg cca gca ggc tcc tcc cag gag gca     1401
 Ser Arg Gln Asp Lys Pro Leu Ser Pro Ala Gly Ser Ser Gln Glu Ala
 355                 360                 365                 370

 gct gac acc ccc gac acg cgg cac ccc tgc agt ctc ggc tcc tcc ctc     1449
 Ala Asp Thr Pro Asp Thr Arg His Pro Cys Ser Leu Gly Ser Ser Leu
                 375                 380                 385

 gtg gcg gac tac tcc gac tcg gag agt gag tga gcgatccc catcctggag     1500
 Val Ala Asp Tyr Ser Asp Ser Glu Ser Glu 
             390                 395

 actggacccg ctctagaggc ccggacacac ccaggaggcc cctcacagac tgcagacccc   1560

 cggctcgccc accagccctg ggagagctca gatgccgcat cctccccaga ccgcgccttc   1620

 ctgcaaccgt ggagttattt atttggtcct ggtgagggtg tttgtgcctt gtgagactcc   1680

 gtacattaaa gacctgtctc ttcttaaaaa aaaaaaa                            1717




      <210> 26
      <211> 5139
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(5139)

      <400> 26
  atg ggg aga gac cag cgc gcg gtg gcc ggc cct gcc cta cgg cgg tgg      48
  Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp
    1               5                  10                  15

 ctg ctg ctg ggg aca gtg acc gtg ggg ttc ctc gcc cag agc gtc ttg       96
 Leu Leu Leu Gly Thr Val Thr Val Gly Phe Leu Ala Gln Ser Val Leu
              20                  25                  30

 gcg ggt gtg aag aag ttt gat gtg ccg tgt gga gga aga gat tgc agt      144
 Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser
          35                  40                  45

 ggg ggc tgc cag tgc tac cct gag aaa ggt gga cgt ggt cag cct ggg      192
 Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly
      50                  55                  60

 cca gtg ggc ccc cag ggg tac aat ggg cca cca gga tta caa gga ttc      240
 Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe
  65                  70                  75                  80

 ccg gga ctg cag gga cgt aaa gga gac aag ggt gaa agg gga gcc ccc      288
 Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro
                  85                  90                  95

 gga gta aca gga ccc aag ggc gac gtg gga gca aga ggc gtt tct gga      336
 Gly Val Thr Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser Gly
             100                 105                 110

 ttc cct ggt gcc gat gga att cct gga cac ccg ggg caa ggt ggg ccc      384
 Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln Gly Gly Pro
         115                 120                 125

 agg gga agg ccg ggc tac gat ggc tgc aac gga acc cag gga gac tca      432
 Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly Thr Gln Gly Asp Ser
     130                 135                 140

 ggt cca cag ggg ccc ccc ggc tct gag ggg ttc acc ggg cct ccc ggg      480
 Gly Pro Gln Gly Pro Pro Gly Ser Glu Gly Phe Thr Gly Pro Pro Gly
 145                 150                 155                 160

 ccc caa gga cca aaa ggg cag aaa ggt gag cct tat gca ctg cct aaa      528
 Pro Gln Gly Pro Lys Gly Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys
                 165                 170                 175

 gag gag cgc gac aga tat cgg ggt gaa cct gga gag cct gga ttg gtc      576
 Glu Glu Arg Asp Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val
             180                 185                 190

 ggt ttc cag gga cct ccc ggc cgc cct ggg cat gtg gga cag atg ggt      624
 Gly Phe Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly
         195                 200                 205

 cca gtt gga gct cca ggg aga cca gga cca cct gga ccc cct gga cca      672
 Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro
     210                 215                 220

 aaa gga cag caa ggc aac aga gga ctt ggt ttc tac gga gtt aag ggt      720
 Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys Gly
 225                 230                 235                 240

 gaa aag ggt gac gta ggg cag ccg gga ccc aac ggg att cca tca gac      768
 Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly Ile Pro Ser Asp
                 245                 250                 255

 acc ctc cac ccc atc atc gcg ccc aca gga gtc acc ttc cac cca gat      816
 Thr Leu His Pro Ile Ile Ala Pro Thr Gly Val Thr Phe His Pro Asp
             260                 265                 270

 cag tac aag ggt gaa aaa ggc agt gag ggg gaa cca gga ata aga ggc      864
 Gln Tyr Lys Gly Glu Lys Gly Ser Glu Gly Glu Pro Gly Ile Arg Gly
         275                 280                 285

 att tcc ttg aag gga gaa gaa gga atc atg ggc ttt cct gga ctt agg      912
 Ile Ser Leu Lys Gly Glu Glu Gly Ile Met Gly Phe Pro Gly Leu Arg
     290                 295                 300

 ggt tac cct ggc ttg agt ggt gaa aaa gga tca cca gga cag aag gga      960
 Gly Tyr Pro Gly Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly
 305                 310                 315                 320

 agc cga ggc ctg gat ggc tat caa ggg cct gat gga ccc cgg gga cct     1008
 Ser Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro
                 325                 330                 335

 aag gga gaa gcc gga gac cca ggg ccc cct gga cta cct gcc tac tcc     1056
 Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser
             340                 345                 350

 cct cac cct tcc cta gca aaa ggt gcc aga ggt gac cca gga ttc cca     1104
 Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly Phe Pro
         355                 360                 365

 ggg gcc caa ggg gag cca gga agc cag ggt gag cca gga gac ccg ggc     1152
 Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro Gly Asp Pro Gly
     370                 375                 380

 ctc cca ggt ccc cct ggc ctc tcc att gga gat gga gat cag agg aga     1200
 Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly Asp Gly Asp Gln Arg Arg
 385                 390                 395                 400

 ggc ctg ccg ggt gag atg gga ccc aag ggc ttc atc gga gac ccc ggc     1248
 Gly Leu Pro Gly Glu Met Gly Pro Lys Gly Phe Ile Gly Asp Pro Gly
                 405                 410                 415

 atc cct gcg ctc tac ggg ggc cca cct gga cct gat gga aag cga ggg     1296
 Ile Pro Ala Leu Tyr Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly
             420                 425                 430

 cct cca gga ccc ccc ggg ctc cct gga cca cct gga cct gat ggc ttc     1344
 Pro Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe
         435                 440                 445

 ctg ttt ggg ctg aaa gga gca aaa gga aga gca ggc ttc cct ggg ctt     1392
 Leu Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu
     450                 455                 460

 ccc ggc tcc cct gga gcc ccc gga cca aag ggg tgg aaa ggt gac gct     1440
 Pro Gly Ser Pro Gly Ala Pro Gly Pro Lys Gly Trp Lys Gly Asp Ala
 465                 470                 475                 480

 ggg gaa tgc aga tgt aca gaa ggc gac gaa gct atc aaa ggt ctt cca     1488
 Gly Glu Cys Arg Cys Thr Glu Gly Asp Glu Ala Ile Lys Gly Leu Pro
                 485                 490                 495

 gga ctg cca gga ccc aag ggc ttc gca ggc atc aac ggg gag ccg ggg     1536
 Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile Asn Gly Glu Pro Gly
             500                 505                 510

 agg aaa ggg gac aaa gga gac ccc ggc caa cac ggc ctc cct ggg ttc     1584
 Arg Lys Gly Asp Lys Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe
         515                 520                 525

 cca ggg ctc aag gga gtg cct ggc aac att ggt gct ccc gga ccc aaa     1632
 Pro Gly Leu Lys Gly Val Pro Gly Asn Ile Gly Ala Pro Gly Pro Lys
     530                 535                 540

 gga gca aaa gga gat tcc aga aca atc aca acc aaa ggt gag cgg gga     1680
 Gly Ala Lys Gly Asp Ser Arg Thr Ile Thr Thr Lys Gly Glu Arg Gly
 545                 550                 555                 560

 cag ccc ggc gtc cca ggt gtg ccc ggg atg aaa ggt gac gat ggc agc     1728
 Gln Pro Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser
                 565                 570                 575

 cca ggc cgc gat ggg ctc gat gga ttc ccc ggc ctc cca ggc cct ccc     1776
 Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro
             580                 585                 590

 ggt gat ggc atc aag ggc cct cca ggg gac cca ggt tat cca gga ata     1824
 Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly Ile
         595                 600                 605

 cct gga acg aag ggt act cca gga gaa atg ggc ccc cca gga ctg ggc     1872
 Pro Gly Thr Lys Gly Thr Pro Gly Glu Met Gly Pro Pro Gly Leu Gly
     610                 615                 620

 ctt ccc ggc ctc aaa ggc caa cgt ggt ttc cct gga gac gcc ggc tta     1920
 Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro Gly Asp Ala Gly Leu
 625                 630                 635                 640

 cct gga cca cca ggc ttc ctg ggc cct cct ggc ccc gca ggg acc cca     1968
 Pro Gly Pro Pro Gly Phe Leu Gly Pro Pro Gly Pro Ala Gly Thr Pro
                 645                 650                 655

 gga caa ata gat tgt gac aca gat gtg aaa agg gcc gtt gga ggt gac     2016
 Gly Gln Ile Asp Cys Asp Thr Asp Val Lys Arg Ala Val Gly Gly Asp
             660                 665                 670

 aga cag gag gcc atc cag cca ggt tgc ata gga ggg ccc aag gga ttg     2064
 Arg Gln Glu Ala Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu
         675                 680                 685

 cca ggc ctg cca gga ccc cca ggc ccc aca ggt gcc aaa ggc ctc cga     2112
 Pro Gly Leu Pro Gly Pro Pro Gly Pro Thr Gly Ala Lys Gly Leu Arg
     690                 695                 700

 gga atc cca ggc ttc gca gga gct gat gga gga cca ggg ccc agg ggc     2160
 Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly
 705                 710                 715                 720

 ttg cca gga gac gca ggt cgt gaa ggg ttc cca gga ccc cca ggg ttc     2208
 Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro Gly Phe
                 725                 730                 735

 ata gga ccc cga gga tcc aaa ggt gca gtg ggc ctc cct ggc cca gat     2256
 Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu Pro Gly Pro Asp
             740                 745                 750

 gga tcc cca ggt ccc atc ggc ctg cca ggg cca gat ggg ccc cct ggg     2304
 Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly Pro Asp Gly Pro Pro Gly
         755                 760                 765

 gaa agg ggc ctc cct gga gaa gtc ctg gga gct cag ccc ggg cca cgg     2352
 Glu Arg Gly Leu Pro Gly Glu Val Leu Gly Ala Gln Pro Gly Pro Arg
     770                 775                 780

 gga gat gct ggt gtg cct gga cag cct ggg ctt aaa ggc ctt ccc gga     2400
 Gly Asp Ala Gly Val Pro Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly
 785                 790                 795                 800

 gac aga ggc ccc cct gga ttc aga gga agc caa ggg atg cct ggg atg     2448
 Asp Arg Gly Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met
                 805                 810                 815

 cca ggg ctg aag ggc cag cca ggc ctc cca gga cct tcc ggc cag cca     2496
 Pro Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro
             820                 825                 830

 ggc ctg tat ggg cct cca gga ctg cat gga ttc cca gga gct cct ggc     2544
 Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly
         835                 840                 845

 caa gag ggg ccc ttg ggg ctg cca gga atc cca ggc cgt gaa ggt ctg     2592
 Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu Gly Leu
     850                 855                 860

 cct ggt gat aga ggg gac cct ggg gac aca ggc gct cct ggc cct gtg     2640
 Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala Pro Gly Pro Val
 865                 870                 875                 880

 ggc atg aaa ggt ctc tct ggt gac aga gga gat gct ggc ttc aca ggg     2688
 Gly Met Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala Gly Phe Thr Gly
                 885                 890                 895

 gag caa ggc cat cca gga agc cct gga ttt aaa gga att gat gga atg     2736
 Glu Gln Gly His Pro Gly Ser Pro Gly Phe Lys Gly Ile Asp Gly Met
             900                 905                 910

 cct ggg acc ccc ggg cta aaa gga gat aga ggc tca cct ggg atg gat     2784
 Pro Gly Thr Pro Gly Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp
         915                 920                 925

 ggt ttc caa ggc atg cct gga ctc aaa ggg aga ccc ggg ttt cca ggg     2832
 Gly Phe Gln Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly
     930                 935                 940

 agc aaa ggc gag gct gga ttt ttc gga ata ccc ggt ctg aag ggt ctg     2880
 Ser Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu
 945                 950                 955                 960

 gct ggt gag cca ggt ttt aaa ggc agc cga ggg gac cct ggg ccc cca     2928
 Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro Pro
                 965                 970                 975

 gga cca cct cct gtc atc ctg cca gga atg aaa gac att aaa gga gag     2976
 Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile Lys Gly Glu
             980                 985                 990

 aaa gga gat gaa ggg cct atg ggg ctg aaa gga tac ctg ggc gca aaa     3024
 Lys Gly Asp Glu Gly Pro Met Gly Leu Lys Gly Tyr Leu Gly Ala Lys
         995                1000                1005

 ggt atc caa gga atg cca ggc atc cca ggg ctg tca gga atc cct ggg     3072
 Gly Ile Gln Gly Met Pro Gly Ile Pro Gly Leu Ser Gly Ile Pro Gly
    1010                1015                1020

 ctg cct ggg agg ccc ggc cac atc aaa gga gtc aag gga gac atc gga     3120
 Leu Pro Gly Arg Pro Gly His Ile Lys Gly Val Lys Gly Asp Ile Gly
1025                1030                1035                1040

 gtc ccc ggc atc ccc ggt ttg cca gga ttc cct ggg gtg gct ggc ccc     3168
 Val Pro Gly Ile Pro Gly Leu Pro Gly Phe Pro Gly Val Ala Gly Pro
                1045                1050                1055

 cct gga att acg gga ttc cca gga ttc ata gga agc cgg ggt gac aaa     3216
 Pro Gly Ile Thr Gly Phe Pro Gly Phe Ile Gly Ser Arg Gly Asp Lys
            1060                1065                1070

 ggt gcc cca ggg aga gca ggc ctg tat ggc gag att ggc gcg act ggt     3264
 Gly Ala Pro Gly Arg Ala Gly Leu Tyr Gly Glu Ile Gly Ala Thr Gly
        1075                1080                1085

 gat ttc ggt gac atc ggg gac act ata aat tta cca gga aga cca ggc     3312
 Asp Phe Gly Asp Ile Gly Asp Thr Ile Asn Leu Pro Gly Arg Pro Gly
    1090                1095                1100

 ctg aag ggg gag cgg ggc acc act gga ata cca ggt ctg aag gga ttc     3360
 Leu Lys Gly Glu Arg Gly Thr Thr Gly Ile Pro Gly Leu Lys Gly Phe
1105                1110                1115                1120

 ttt gga gag aag gga aca gaa ggt gac atc ggc ttc cct ggg ata aca     3408
 Phe Gly Glu Lys Gly Thr Glu Gly Asp Ile Gly Phe Pro Gly Ile Thr
                1125                1130                1135

 ggc gtg act gga gtc caa ggc cct cct gga ctt aaa gga caa aca ggc     3456
 Gly Val Thr Gly Val Gln Gly Pro Pro Gly Leu Lys Gly Gln Thr Gly
            1140                1145                1150

 ttt cca ggg ctg act ggg cct cca ggg tcg cag gga gag ctg ggg cgg     3504
 Phe Pro Gly Leu Thr Gly Pro Pro Gly Ser Gln Gly Glu Leu Gly Arg
        1155                1160                1165

 att gga ctg cct ggt ggc aaa gga gat gat ggc tgg ccg gga gct ccg     3552
 Ile Gly Leu Pro Gly Gly Lys Gly Asp Asp Gly Trp Pro Gly Ala Pro
    1170                1175                1180

 ggc tta cca ggt ttt ccg gga ctc cgt ggg atc cgc ggc tta cac ggc     3600
 Gly Leu Pro Gly Phe Pro Gly Leu Arg Gly Ile Arg Gly Leu His Gly
1185                1190                1195                1200

 ttg cca ggc acc aag ggc ttt cca gga tcc cca ggt tct gac atc cac     3648
 Leu Pro Gly Thr Lys Gly Phe Pro Gly Ser Pro Gly Ser Asp Ile His
                1205                1210                1215

 gga gac cca ggc ttc cca ggc cct cct ggg gaa aga ggt gac cca gga     3696
 Gly Asp Pro Gly Phe Pro Gly Pro Pro Gly Glu Arg Gly Asp Pro Gly
            1220                1225                1230

 gag gcc aac acc ctt cca ggc cct gtg gga gtc cca gga cag aaa gga     3744
 Glu Ala Asn Thr Leu Pro Gly Pro Val Gly Val Pro Gly Gln Lys Gly
        1235                1240                1245

 gac caa gga gct cca ggg gaa cga ggc cca cct ggg agc cca gga ctt     3792
 Asp Gln Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Ser Pro Gly Leu
    1250                1255                1260

 cag ggg ttc cca ggc atc aca ccc cct tcc aac atc tct ggg gca cct     3840
 Gln Gly Phe Pro Gly Ile Thr Pro Pro Ser Asn Ile Ser Gly Ala Pro
1265                1270                1275                1280

 ggt gac aaa ggg gcg cca ggg ata ttt ggc ctg aaa ggt tat cgg ggc     3888
 Gly Asp Lys Gly Ala Pro Gly Ile Phe Gly Leu Lys Gly Tyr Arg Gly
                1285                1290                1295

 cca cca ggg cca cca ggt tct gct gct ctt cct gga agc aaa ggt gac     3936
 Pro Pro Gly Pro Pro Gly Ser Ala Ala Leu Pro Gly Ser Lys Gly Asp
            1300                1305                1310

 aca ggg aac cca gga gct cca gga acc cca ggg acc aaa gga tgg gcc     3984
 Thr Gly Asn Pro Gly Ala Pro Gly Thr Pro Gly Thr Lys Gly Trp Ala
        1315                1320                1325

 ggg gac tcc ggg ccc cag ggc agg cct ggt gtg ttt ggt ctc cca gga     4032
 Gly Asp Ser Gly Pro Gln Gly Arg Pro Gly Val Phe Gly Leu Pro Gly
    1330                1335                1340

 gaa aaa ggg ccc agg ggt gaa caa ggc ttc atg ggg aac act gga ccc     4080
 Glu Lys Gly Pro Arg Gly Glu Gln Gly Phe Met Gly Asn Thr Gly Pro
1345                1350                1355                1360

 acc ggg gcg gtg ggc gac aga ggc ccc aag gga ccc aag gga gac cca     4128
 Thr Gly Ala Val Gly Asp Arg Gly Pro Lys Gly Pro Lys Gly Asp Pro
                1365                1370                1375

 gga ttc cct ggt gcc ccc ggg act gtg gga gcc ccc ggg att gca gga     4176
 Gly Phe Pro Gly Ala Pro Gly Thr Val Gly Ala Pro Gly Ile Ala Gly
            1380                1385                1390

 atc ccc cag aag att gcc gtc caa cca ggg aca gtg ggt ccc cag ggg     4224
 Ile Pro Gln Lys Ile Ala Val Gln Pro Gly Thr Val Gly Pro Gln Gly
        1395                1400                1405

 agg cga ggc ccc cct ggg gca ccg ggg gag atg ggg ccc cag ggc ccc     4272
 Arg Arg Gly Pro Pro Gly Ala Pro Gly Glu Met Gly Pro Gln Gly Pro
    1410                1415                1420

 ccc gga gaa cca ggt ttt cgt ggg gct cca ggg aaa gct ggg ccc caa     4320
 Pro Gly Glu Pro Gly Phe Arg Gly Ala Pro Gly Lys Ala Gly Pro Gln
1425                1430                1435                1440

 gga aga ggt ggt gtg tct gct gtt ccc ggc ttc cgg gga gat gaa gga     4368
 Gly Arg Gly Gly Val Ser Ala Val Pro Gly Phe Arg Gly Asp Glu Gly
                1445                1450                1455

 ccc ata ggc cac cag ggg ccg att ggc caa gaa ggt gca cca ggc cgt     4416
 Pro Ile Gly His Gln Gly Pro Ile Gly Gln Glu Gly Ala Pro Gly Arg
            1460                1465                1470

 cca ggg agc ccg ggc ctg ccg ggt atg cca ggc cgc agc gtc agc atc     4464
 Pro Gly Ser Pro Gly Leu Pro Gly Met Pro Gly Arg Ser Val Ser Ile
        1475                1480                1485

 ggc tac ctc ctg gtg aag cac agc cag acg gac cag gag ccc atg tgc     4512
 Gly Tyr Leu Leu Val Lys His Ser Gln Thr Asp Gln Glu Pro Met Cys
    1490                1495                1500

 cca gtg ggc atg aac aaa ctc tgg agt gga tac agc ctg ctg tac ttc     4560
 Pro Val Gly Met Asn Lys Leu Trp Ser Gly Tyr Ser Leu Leu Tyr Phe
1505                1510                1515                1520

 gag ggc cag gag aag gcg cac aac cag gac ctg ggg ctg gcg ggc tcc     4608
 Glu Gly Gln Glu Lys Ala His Asn Gln Asp Leu Gly Leu Ala Gly Ser
                1525                1530                1535

 tgc ctg gcg cgg ttc agc acc atg ccc ttc ctg tac tgc aac cct ggt     4656
 Cys Leu Ala Arg Phe Ser Thr Met Pro Phe Leu Tyr Cys Asn Pro Gly
            1540                1545                1550

 gat gtc tgc tac tat gcc agc cgg aac gac aag tcc tac tgg ctc tct     4704
 Asp Val Cys Tyr Tyr Ala Ser Arg Asn Asp Lys Ser Tyr Trp Leu Ser
        1555                1560                1565

 acc act gcg ccg ctg ccc atg atg ccc gtg gcc gag gac gag atc aag     4752
 Thr Thr Ala Pro Leu Pro Met Met Pro Val Ala Glu Asp Glu Ile Lys
    1570                1575                1580

 ccc tac atc agc cgc tgt tct gtg tgt gag gcc ccg gcc atc gcc atc     4800
 Pro Tyr Ile Ser Arg Cys Ser Val Cys Glu Ala Pro Ala Ile Ala Ile
1585                1590                1595                1600

 gcg gtc cac agt cag gat gtc tcc atc cca cac tgc cca gct ggg tgg     4848
 Ala Val His Ser Gln Asp Val Ser Ile Pro His Cys Pro Ala Gly Trp
                1605                1610                1615

 cgg agt ttg tgg atc gga tat tcc ttc ctc atg cac acg gcg gcg gga     4896
 Arg Ser Leu Trp Ile Gly Tyr Ser Phe Leu Met His Thr Ala Ala Gly
            1620                1625                1630

 gac gaa ggc ggt ggc caa tca ctg gtg tca ccg ggc agc tgt cta gag     4944
 Asp Glu Gly Gly Gly Gln Ser Leu Val Ser Pro Gly Ser Cys Leu Glu
        1635                1640                1645

 gac ttc cgc gcc aca cca ttc atc gaa tgc aat gga ggc cgc ggc acc     4992
 Asp Phe Arg Ala Thr Pro Phe Ile Glu Cys Asn Gly Gly Arg Gly Thr
    1650                1655                1660

 tgc cac tac tac gcc aac aag tac agc ttc tgg ctg acc acc att ccc     5040
 Cys His Tyr Tyr Ala Asn Lys Tyr Ser Phe Trp Leu Thr Thr Ile Pro
1665                1670                1675                1680

 gag cag agc ttc cag ggc tcg ccc tcc gcc gac acg ctc aag gcc ggc     5088
 Glu Gln Ser Phe Gln Gly Ser Pro Ser Ala Asp Thr Leu Lys Ala Gly
                1685                1690                1695

 ctc atc cgc aca cac atc agc cgc tgc cag gtg tgc atg aag aac ctg     5136
 Leu Ile Arg Thr His Ile Ser Arg Cys Gln Val Cys Met Lys Asn Leu
            1700                1705                1710

 tga                                                                 5139
 






      <210> 27
      <211> 16545
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (862)..(14772)

      <400> 27
 aaagacagaa ccccagagaa aaacgctgcc aattcgttgc tttattgttc cctgcctggg     60

 gacctcaata gccttttcca ttaaccttcc cttcttacgc aacggttaat gactttgggg    120

 gttgttttgc tttctgtttc tgctgagtca ctaaattttg cctctttgtc cccaggtgct    180

 gctcagcata aaagttaaaa gtgcaattca ggaagtactg ggattctgtg tagagccgag    240

 gaaaccattt ccctaagaga agctctgttc cttggcttgt ccttccttcc cgggaaggaa    300

 gcttccgagg aacgaaggga gaagctttgt tttgcctgca gaagcagccc tgtgctcggc    360

 tgagggttct cagctggctg tgaactgcgg agcattgtag gcgcctggct ggctcaggcc    420

 aatgcagaag tctctccctt ctccaaagac ccaaatcccc acagaaccag cttcgagtta    480

 ctttcccttc aaggggatta aaataattgt gatttgtggc gctctccgtt cgcggtggta    540

 ttttcctgtt gtgttaaatg cctcttatta agtaatagat gtgatttatg tgaacgacga    600

 aggggtgtgt ggtggattcg gtgattaatc agtgaattcc catccgctgg catctctcac    660

 tgcccctctt gcgtgatgta agatcagacg taccctgcat tgaaaagtca agacacacgg    720

 gcgtctcgct cgcgctcaca cacgctctgc ctcctctctc cagcacgcgc gcatccctcc    780

 accttccaca tcctgctcca ggcaggagaa ggctgactgg ctggactcat tgagctgaag    840

 aatttccagt gacatttgta a  atg acg ccg ctc ggt tcc agg ctc caa gcg     891
                          Met Thr Pro Leu Gly Ser Arg Leu Gln Ala
                            1               5                  10

 gcc cct gcc gcc gcc gcc gcc gcc ggg ccg aag gtg ccg ccg agc agt      939
 Ala Pro Ala Ala Ala Ala Ala Ala Gly Pro Lys Val Pro Pro Ser Ser
                  15                  20                  25

 ctc cag cgc agg ctt cct tac cgg gcg acc aca atg tcc gag ttt ctc      987
 Leu Gln Arg Arg Leu Pro Tyr Arg Ala Thr Thr Met Ser Glu Phe Leu
              30                  35                  40

 ctc gcc tta ctc act ctc tcg gga tta ttg ccg att gcc agg gtg ctg     1035
 Leu Ala Leu Leu Thr Leu Ser Gly Leu Leu Pro Ile Ala Arg Val Leu
          45                  50                  55

 acc gtg gga gcc gac cga gat cag cag ttg tgt gat cct ggt gaa ttt     1083
 Thr Val Gly Ala Asp Arg Asp Gln Gln Leu Cys Asp Pro Gly Glu Phe
      60                  65                  70

 ctt tgc cac gat cac gtg act tgt gtc tcc cgg agc tgg ctg tgt gat     1131
 Leu Cys His Asp His Val Thr Cys Val Ser Arg Ser Trp Leu Cys Asp
  75                  80                  85                  90

 ggg gac cct gac tgc cct gat gat tca gac gag tct tta gat acc tgt     1179
 Gly Asp Pro Asp Cys Pro Asp Asp Ser Asp Glu Ser Leu Asp Thr Cys
                  95                 100                 105

 ccc gag gag gta gaa atc aag tgc ccc ttg aat cac att gct tgc ctt     1227
 Pro Glu Glu Val Glu Ile Lys Cys Pro Leu Asn His Ile Ala Cys Leu
             110                 115                 120

 ggt acc aac aaa tgt gtt cat tta tcc cag ctg tgc aat ggt gtc ttg     1275
 Gly Thr Asn Lys Cys Val His Leu Ser Gln Leu Cys Asn Gly Val Leu
         125                 130                 135

 gac tgc cca gat ggg tat gac gaa gga gta cat tgt cag gaa ctg tta     1323
 Asp Cys Pro Asp Gly Tyr Asp Glu Gly Val His Cys Gln Glu Leu Leu
     140                 145                 150

 tcc aat tgc caa cag ctg aat tgt cag tat aaa tgt aca atg gtc aga     1371
 Ser Asn Cys Gln Gln Leu Asn Cys Gln Tyr Lys Cys Thr Met Val Arg
 155                 160                 165                 170

 aat agt aca aga tgt tac tgt gag gat gga ttc gaa ata aca gaa gat     1419
 Asn Ser Thr Arg Cys Tyr Cys Glu Asp Gly Phe Glu Ile Thr Glu Asp
                 175                 180                 185

 ggg aga agc tgt aaa gat caa gat gaa tgt gct gtt tat ggt aca tgc     1467
 Gly Arg Ser Cys Lys Asp Gln Asp Glu Cys Ala Val Tyr Gly Thr Cys
             190                 195                 200

 agc cag acc tgc aga aac aca cat gga tcc tac act tgc agt tgt gtg     1515
 Ser Gln Thr Cys Arg Asn Thr His Gly Ser Tyr Thr Cys Ser Cys Val
         205                 210                 215

 gaa ggc tac cta atg cag cca gac aac aga tct tgc aag gct aaa att     1563
 Glu Gly Tyr Leu Met Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Ile
     220                 225                 230

 gaa cct aca gat aga cca cct ata cta tta att gca aat ttt gaa aca     1611
 Glu Pro Thr Asp Arg Pro Pro Ile Leu Leu Ile Ala Asn Phe Glu Thr
 235                 240                 245                 250

 att gag gtt ttc tat ctt aat gga agt aaa atg gca act cta agc tca     1659
 Ile Glu Val Phe Tyr Leu Asn Gly Ser Lys Met Ala Thr Leu Ser Ser
                 255                 260                 265

 gtc aat gga aat gaa att cat act ctg gat ttt att tat aat gaa gat     1707
 Val Asn Gly Asn Glu Ile His Thr Leu Asp Phe Ile Tyr Asn Glu Asp
             270                 275                 280

 gtg att tgt tgg att gaa tca aga gaa tct tca aat caa ctc aaa tgt     1755
 Val Ile Cys Trp Ile Glu Ser Arg Glu Ser Ser Asn Gln Leu Lys Cys
         285                 290                 295

 atc cag ata aca aaa gca gga gga tta aca gat gaa tgg aca atc aat     1803
 Ile Gln Ile Thr Lys Ala Gly Gly Leu Thr Asp Glu Trp Thr Ile Asn
     300                 305                 310

 att ctt caa tcc ttc cac aat gtg caa caa atg gcg att gac tgg ctc     1851
 Ile Leu Gln Ser Phe His Asn Val Gln Gln Met Ala Ile Asp Trp Leu
 315                 320                 325                 330

 act cga aat ctc tat ttt gtg gac cat gtc ggt gac cgg atc ttt gtt     1899
 Thr Arg Asn Leu Tyr Phe Val Asp His Val Gly Asp Arg Ile Phe Val
                 335                 340                 345

 tgt aat tcc aac ggt tct gta tgt gtc acc ctg att gat ctg gag ctt     1947
 Cys Asn Ser Asn Gly Ser Val Cys Val Thr Leu Ile Asp Leu Glu Leu
             350                 355                 360

 cac aat cct aaa gca ata gca gta gat cca ata gca gga aaa ctt ttc     1995
 His Asn Pro Lys Ala Ile Ala Val Asp Pro Ile Ala Gly Lys Leu Phe
         365                 370                 375

 ttt act gac tac ggg aat gtc gcc aaa gtg gag aga tgt gac atg gat     2043
 Phe Thr Asp Tyr Gly Asn Val Ala Lys Val Glu Arg Cys Asp Met Asp
     380                 385                 390

 ggg atg aac cga aca agg ata att gat tca aag aca gag cag cca gct     2091
 Gly Met Asn Arg Thr Arg Ile Ile Asp Ser Lys Thr Glu Gln Pro Ala
 395                 400                 405                 410

 gca ctg gca cta gac cta gtc aac aaa ttg gtt tac tgg gta gat ctt     2139
 Ala Leu Ala Leu Asp Leu Val Asn Lys Leu Val Tyr Trp Val Asp Leu
                 415                 420                 425

 tac ttg gac tat gtg gga gta gtg gac tat caa gga aaa aat aga cac     2187
 Tyr Leu Asp Tyr Val Gly Val Val Asp Tyr Gln Gly Lys Asn Arg His
             430                 435                 440

 act gtc att caa ggc aga caa gtc aga cat ctt tat ggt ata act gtg     2235
 Thr Val Ile Gln Gly Arg Gln Val Arg His Leu Tyr Gly Ile Thr Val
         445                 450                 455

 ttt gaa gat tat ttg tat gca acc aat tct gat aac tac aat atc gta     2283
 Phe Glu Asp Tyr Leu Tyr Ala Thr Asn Ser Asp Asn Tyr Asn Ile Val
     460                 465                 470

 agg ata aac cga ttt aat ggg act gat att cac tca tta att aaa att     2331
 Arg Ile Asn Arg Phe Asn Gly Thr Asp Ile His Ser Leu Ile Lys Ile
 475                 480                 485                 490

 gag aat gct tgg gga atc cga att tat caa aaa aga act caa cca aca     2379
 Glu Asn Ala Trp Gly Ile Arg Ile Tyr Gln Lys Arg Thr Gln Pro Thr
                 495                 500                 505

 gtc aga agc cat gca tgt gaa gtc gat cca tat gga atg cca ggg ggc     2427
 Val Arg Ser His Ala Cys Glu Val Asp Pro Tyr Gly Met Pro Gly Gly
             510                 515                 520

 tgt tca cac atc tgt cta ctc agc agc agt tac aaa act cgg act tgt     2475
 Cys Ser His Ile Cys Leu Leu Ser Ser Ser Tyr Lys Thr Arg Thr Cys
         525                 530                 535

 cgc tgc agg act ggc ttc aac ttg gga agt gat ggc agg tca tgc aaa     2523
 Arg Cys Arg Thr Gly Phe Asn Leu Gly Ser Asp Gly Arg Ser Cys Lys
     540                 545                 550

 aga cca aag aat gag ttg ttc ctc ttt tat ggg aaa gga cgc cca gga     2571
 Arg Pro Lys Asn Glu Leu Phe Leu Phe Tyr Gly Lys Gly Arg Pro Gly
 555                 560                 565                 570

 att gtt aga gga atg gac ttg aat acc aag ata gct gat gaa tac atg     2619
 Ile Val Arg Gly Met Asp Leu Asn Thr Lys Ile Ala Asp Glu Tyr Met
                 575                 580                 585

 atc ccc ata gaa aat ctg gta aac cct cgt gct tta gac ttt cac gca     2667
 Ile Pro Ile Glu Asn Leu Val Asn Pro Arg Ala Leu Asp Phe His Ala
             590                 595                 600

 gaa acc aat tac atc tac ttt gct gac acc acc agt ttc cta att ggc     2715
 Glu Thr Asn Tyr Ile Tyr Phe Ala Asp Thr Thr Ser Phe Leu Ile Gly
         605                 610                 615

 cgg cag aag ata gat ggc aca gag aga gaa acc atc ctg aaa gat gat     2763
 Arg Gln Lys Ile Asp Gly Thr Glu Arg Glu Thr Ile Leu Lys Asp Asp
     620                 625                 630

 ctg gat aat gta gag ggc att gct gtg gac tgg att gga aat aat ctt     2811
 Leu Asp Asn Val Glu Gly Ile Ala Val Asp Trp Ile Gly Asn Asn Leu
 635                 640                 645                 650

 tac tgg acc aat gat ggc cat agg aaa acc att aat gtg gct agg ctg     2859
 Tyr Trp Thr Asn Asp Gly His Arg Lys Thr Ile Asn Val Ala Arg Leu
                 655                 660                 665

 gaa aaa gct tct cag agt cgg aag act ctt tta gag ggt gaa atg tct     2907
 Glu Lys Ala Ser Gln Ser Arg Lys Thr Leu Leu Glu Gly Glu Met Ser
             670                 675                 680

 cat ccc aga gga att gtg gtg gat cca att aat ggt tgg atg tat tgg     2955
 His Pro Arg Gly Ile Val Val Asp Pro Ile Asn Gly Trp Met Tyr Trp
         685                 690                 695

 aca gac tgg gag gaa gat gaa ata gat gac agc gtg gga agg att gag     3003
 Thr Asp Trp Glu Glu Asp Glu Ile Asp Asp Ser Val Gly Arg Ile Glu
     700                 705                 710

 aag gcc tgg atg gat gga ttc aat cgg cag att ttt gtg act tca aag     3051
 Lys Ala Trp Met Asp Gly Phe Asn Arg Gln Ile Phe Val Thr Ser Lys
 715                 720                 725                 730

 atg ctg tgg cca aac ggt tta act ctg gac ttt cac acc aac aca tta     3099
 Met Leu Trp Pro Asn Gly Leu Thr Leu Asp Phe His Thr Asn Thr Leu
                 735                 740                 745

 tac tgg tgt gat gcc tat tac gat cat att gaa aaa gta ttt ttg aat     3147
 Tyr Trp Cys Asp Ala Tyr Tyr Asp His Ile Glu Lys Val Phe Leu Asn
             750                 755                 760

 ggg act cac agg aag att gtt tac agt ggg aga gag ttg aac cac cct     3195
 Gly Thr His Arg Lys Ile Val Tyr Ser Gly Arg Glu Leu Asn His Pro
         765                 770                 775

 ttc gga ctg tcg cat cat gga aat tat gtg ttc tgg act gat tat atg     3243
 Phe Gly Leu Ser His His Gly Asn Tyr Val Phe Trp Thr Asp Tyr Met
     780                 785                 790

 aat ggt tcc att ttt caa cta gat ttg ata aca agt gag gtg aca ttg     3291
 Asn Gly Ser Ile Phe Gln Leu Asp Leu Ile Thr Ser Glu Val Thr Leu
 795                 800                 805                 810

 ctg agg cat gaa aga cca ccc cta ttt ggg ctt cag att tat gat cca     3339
 Leu Arg His Glu Arg Pro Pro Leu Phe Gly Leu Gln Ile Tyr Asp Pro
                 815                 820                 825

 cga aag caa caa ggt gac aat atg tgc cga gta aat aat ggg ggc tgt     3387
 Arg Lys Gln Gln Gly Asp Asn Met Cys Arg Val Asn Asn Gly Gly Cys
             830                 835                 840

 agt aca ctt tgc ttg gct atc cca gga ggc cgg gtg tgt gct tgt gcc     3435
 Ser Thr Leu Cys Leu Ala Ile Pro Gly Gly Arg Val Cys Ala Cys Ala
         845                 850                 855

 gat aat caa ctt ttg gat gaa aat ggg aca act tgc aca ttt aat cct     3483
 Asp Asn Gln Leu Leu Asp Glu Asn Gly Thr Thr Cys Thr Phe Asn Pro
     860                 865                 870

 gga gaa gca cta cct cac ata tgt aaa gct gga gag ttt cgc tgc aaa     3531
 Gly Glu Ala Leu Pro His Ile Cys Lys Ala Gly Glu Phe Arg Cys Lys
 875                 880                 885                 890

 aac aga cac tgt atc caa gct cgg tgg aaa tgt gat ggc gac gat gac     3579
 Asn Arg His Cys Ile Gln Ala Arg Trp Lys Cys Asp Gly Asp Asp Asp
                 895                 900                 905

 tgc cta gac gga agc gat gag gat tca gta aac tgc ttc aat cat agc     3627
 Cys Leu Asp Gly Ser Asp Glu Asp Ser Val Asn Cys Phe Asn His Ser
             910                 915                 920

 tgt cct gat gat cag ttt aaa tgc cag aat aat cgc tgc atc ccc aag     3675
 Cys Pro Asp Asp Gln Phe Lys Cys Gln Asn Asn Arg Cys Ile Pro Lys
         925                 930                 935

 aga tgg ctt tgt gat gga gct aat gac tgt ggg agc aat gaa gat gaa     3723
 Arg Trp Leu Cys Asp Gly Ala Asn Asp Cys Gly Ser Asn Glu Asp Glu
     940                 945                 950

 tcc aat caa act tgc aca gcc aga aca tgc cag gta gac cag ttt tct     3771
 Ser Asn Gln Thr Cys Thr Ala Arg Thr Cys Gln Val Asp Gln Phe Ser
 955                 960                 965                 970

 tgc gga aat ggg cgt tgc att ccc aga gca tgg ctg tgt gac agg gaa     3819
 Cys Gly Asn Gly Arg Cys Ile Pro Arg Ala Trp Leu Cys Asp Arg Glu
                 975                 980                 985

 gac gac tgt ggt gac cag aca gat gaa atg gca tct tgt gaa ttc cca     3867
 Asp Asp Cys Gly Asp Gln Thr Asp Glu Met Ala Ser Cys Glu Phe Pro
             990                 995                1000

 act tgt gag cca cta acc caa ttc gta tgc aaa agt gga aga tgc att     3915
 Thr Cys Glu Pro Leu Thr Gln Phe Val Cys Lys Ser Gly Arg Cys Ile
        1005                1010                1015

 agc agc aaa tgg cac tgc gac tct gat gac gac tgt ggg gac ggg agt     3963
 Ser Ser Lys Trp His Cys Asp Ser Asp Asp Asp Cys Gly Asp Gly Ser
    1020                1025                1030

 gat gag gtg ggc tgt gtt cac tct tgc ttt gat aat cag ttc aga tgt     4011
 Asp Glu Val Gly Cys Val His Ser Cys Phe Asp Asn Gln Phe Arg Cys
1035                1040                1045                1050

 tcc agt ggc aga tgc atc cca ggc cac tgg gcc tgt gat ggt gac aat     4059
 Ser Ser Gly Arg Cys Ile Pro Gly His Trp Ala Cys Asp Gly Asp Asn
                1055                1060                1065

 gac tgt ggg gac ttc agt gat gaa gcc cag atc aat tgt act aaa gaa     4107
 Asp Cys Gly Asp Phe Ser Asp Glu Ala Gln Ile Asn Cys Thr Lys Glu
            1070                1075                1080

 gag att cat tct cct gct ggt tgt aac gga aat gaa ttt cag tgc cac     4155
 Glu Ile His Ser Pro Ala Gly Cys Asn Gly Asn Glu Phe Gln Cys His
        1085                1090                1095

 cct gat ggt aat tgc gtt cct gat ttg tgg cgc tgt gat gga gaa aaa     4203
 Pro Asp Gly Asn Cys Val Pro Asp Leu Trp Arg Cys Asp Gly Glu Lys
    1100                1105                1110

 gac tgt gaa gat ggt agt gat gaa aaa ggt tgc aat ggt acc ata cga     4251
 Asp Cys Glu Asp Gly Ser Asp Glu Lys Gly Cys Asn Gly Thr Ile Arg
1115                1120                1125                1130

 ttg tgt gac cac aaa acc aag ttt tcc tgt tgg agt aca ggg aga tgc     4299
 Leu Cys Asp His Lys Thr Lys Phe Ser Cys Trp Ser Thr Gly Arg Cys
                1135                1140                1145

 atc aac aaa gca tgg gtg tgt gat gga gat att gat tgc gaa gat cag     4347
 Ile Asn Lys Ala Trp Val Cys Asp Gly Asp Ile Asp Cys Glu Asp Gln
            1150                1155                1160

 tca gat gaa gat gac tgt gac agt ttc ttg tgt gga cca ccc aag cat     4395
 Ser Asp Glu Asp Asp Cys Asp Ser Phe Leu Cys Gly Pro Pro Lys His
        1165                1170                1175

 cct tgt gct aat gac acc tca gtc tgc ctg cag cca gag aaa ctc tgc     4443
 Pro Cys Ala Asn Asp Thr Ser Val Cys Leu Gln Pro Glu Lys Leu Cys
    1180                1185                1190

 aat ggg aaa aag gat tgt cct gat ggc tct gat gaa ggc tat ctc tgt     4491
 Asn Gly Lys Lys Asp Cys Pro Asp Gly Ser Asp Glu Gly Tyr Leu Cys
1195                1200                1205                1210

 gat gag tgt tcg ctg aac aat gga ggc tgt agc aac cac tgt tct gtt     4539
 Asp Glu Cys Ser Leu Asn Asn Gly Gly Cys Ser Asn His Cys Ser Val
                1215                1220                1225

 gtt cct gga aga gga att gtc tgt tcc tgc cct gaa gga ctt caa ctc     4587
 Val Pro Gly Arg Gly Ile Val Cys Ser Cys Pro Glu Gly Leu Gln Leu
            1230                1235                1240

 aac aaa gac aat aaa aca tgt gaa att gtg gat tat tgt agc aat cat     4635
 Asn Lys Asp Asn Lys Thr Cys Glu Ile Val Asp Tyr Cys Ser Asn His
        1245                1250                1255

 cta aag tgc agc caa gta tgt gag cag cac aag cac aca gtc aag tgc     4683
 Leu Lys Cys Ser Gln Val Cys Glu Gln His Lys His Thr Val Lys Cys
    1260                1265                1270

 tca tgt tat gaa ggt tgg aag ctg gat gta gac ggt gaa agt tgt aca     4731
 Ser Cys Tyr Glu Gly Trp Lys Leu Asp Val Asp Gly Glu Ser Cys Thr
1275                1280                1285                1290

 agt gtt gat cct ttt gaa gca ttc atc atc ttt tct att cgt cat gag     4779
 Ser Val Asp Pro Phe Glu Ala Phe Ile Ile Phe Ser Ile Arg His Glu
                1295                1300                1305

 atc aga agg att gat ctt cac aaa aga gac tat agt cta ctt gtt cct     4827
 Ile Arg Arg Ile Asp Leu His Lys Arg Asp Tyr Ser Leu Leu Val Pro
            1310                1315                1320

 gga ttg aga aac aca ata gca ctt gat ttt cac ttc aat caa agt tta     4875
 Gly Leu Arg Asn Thr Ile Ala Leu Asp Phe His Phe Asn Gln Ser Leu
        1325                1330                1335

 ctt tat tgg aca gat gtt gta gaa gac aga ata tac cgg gga aag ctt     4923
 Leu Tyr Trp Thr Asp Val Val Glu Asp Arg Ile Tyr Arg Gly Lys Leu
    1340                1345                1350

 tct gaa agt gga ggt gtc agt gcc att gaa gtg gtt gtg gag cat ggc     4971
 Ser Glu Ser Gly Gly Val Ser Ala Ile Glu Val Val Val Glu His Gly
1355                1360                1365                1370

 ctg gct act cca gaa ggc ctg aca gtc gac tgg ata gca gga aac ata     5019
 Leu Ala Thr Pro Glu Gly Leu Thr Val Asp Trp Ile Ala Gly Asn Ile
                1375                1380                1385

 tac tgg ata gac agc aat ctg gac caa atc gaa gtg gcc aaa cta gat     5067
 Tyr Trp Ile Asp Ser Asn Leu Asp Gln Ile Glu Val Ala Lys Leu Asp
            1390                1395                1400

 ggc tcc cta aga act aca cta ata gca gga gcc atg gaa cac ccc agg     5115
 Gly Ser Leu Arg Thr Thr Leu Ile Ala Gly Ala Met Glu His Pro Arg
        1405                1410                1415

 gcc att gct ttg gac cca aga tat gga att ctt ttc tgg aca gac tgg     5163
 Ala Ile Ala Leu Asp Pro Arg Tyr Gly Ile Leu Phe Trp Thr Asp Trp
    1420                1425                1430

 gat gca aat ttt cct cgc att gaa tct gcc tct atg agt ggt gct ggg     5211
 Asp Ala Asn Phe Pro Arg Ile Glu Ser Ala Ser Met Ser Gly Ala Gly
1435                1440                1445                1450

 aga aaa acc atc tat aaa gac atg aaa act ggg gct tgg cct aat gga     5259
 Arg Lys Thr Ile Tyr Lys Asp Met Lys Thr Gly Ala Trp Pro Asn Gly
                1455                1460                1465

 cta act gtg gac cac ttt gag aaa agg ata gtg tgg aca gac gcc agg     5307
 Leu Thr Val Asp His Phe Glu Lys Arg Ile Val Trp Thr Asp Ala Arg
            1470                1475                1480

 tca gat gct att tat tca gcc ctc tat gat gga aca aac atg ata gaa     5355
 Ser Asp Ala Ile Tyr Ser Ala Leu Tyr Asp Gly Thr Asn Met Ile Glu
        1485                1490                1495

 atc atc cga ggt cat gaa tac ctt tcc cat ccc ttt gct gtg tct cta     5403
 Ile Ile Arg Gly His Glu Tyr Leu Ser His Pro Phe Ala Val Ser Leu
    1500                1505                1510

 tat ggg agt gaa gtc tac tgg aca gac tgg agg acc aac aca ttg tcc     5451
 Tyr Gly Ser Glu Val Tyr Trp Thr Asp Trp Arg Thr Asn Thr Leu Ser
1515                1520                1525                1530

 aaa gcc aat aag tgg aca ggg cag aat gtc agt gtg att cag aaa acc     5499
 Lys Ala Asn Lys Trp Thr Gly Gln Asn Val Ser Val Ile Gln Lys Thr
                1535                1540                1545

 agt gca cag cca ttt gac ctt cag ata tac cat ccc agt cgc cag cca     5547
 Ser Ala Gln Pro Phe Asp Leu Gln Ile Tyr His Pro Ser Arg Gln Pro
            1550                1555                1560

 cag gct ccc aat cct tgt gca gct aat gat ggc aaa ggc ccc tgc tct     5595
 Gln Ala Pro Asn Pro Cys Ala Ala Asn Asp Gly Lys Gly Pro Cys Ser
        1565                1570                1575

 cac atg tgt cta atc aat cac aat agg agt gct gcc tgt gcg tgc ccc     5643
 His Met Cys Leu Ile Asn His Asn Arg Ser Ala Ala Cys Ala Cys Pro
    1580                1585                1590

 cac ttg atg aag ctt tct tca gac aag aag acc tgc tat gaa atg aaa     5691
 His Leu Met Lys Leu Ser Ser Asp Lys Lys Thr Cys Tyr Glu Met Lys
1595                1600                1605                1610

 aaa ttt ctt ctt tat gca aga cgt tct gaa atc aga gga gtg gat att     5739
 Lys Phe Leu Leu Tyr Ala Arg Arg Ser Glu Ile Arg Gly Val Asp Ile
                1615                1620                1625

 gac aat cca tac ttt aac ttc atc acg gca ttt aca gtc cct gat att     5787
 Asp Asn Pro Tyr Phe Asn Phe Ile Thr Ala Phe Thr Val Pro Asp Ile
            1630                1635                1640

 gat gac gtt act gtg ata gac ttc gat gca tct gag gaa cgt tta tac     5835
 Asp Asp Val Thr Val Ile Asp Phe Asp Ala Ser Glu Glu Arg Leu Tyr
        1645                1650                1655

 tgg aca gat att aaa aca caa acc att aaa cga gct ttt att aac gga     5883
 Trp Thr Asp Ile Lys Thr Gln Thr Ile Lys Arg Ala Phe Ile Asn Gly
    1660                1665                1670

 act ggg tta gaa act gtt att tca aga gat att cag agt atc aga ggg     5931
 Thr Gly Leu Glu Thr Val Ile Ser Arg Asp Ile Gln Ser Ile Arg Gly
1675                1680                1685                1690

 cta gca gtg gat tgg gtg tca cgt aat tta tac tgg att agc tca gaa     5979
 Leu Ala Val Asp Trp Val Ser Arg Asn Leu Tyr Trp Ile Ser Ser Glu
                1695                1700                1705

 ttt gat gaa acg caa att aat gtg gca agg cta gat ggc tct ttg aaa     6027
 Phe Asp Glu Thr Gln Ile Asn Val Ala Arg Leu Asp Gly Ser Leu Lys
            1710                1715                1720

 acc tca att atc cat gga atc gat aag cca cag tgt ctt gca gct cac     6075
 Thr Ser Ile Ile His Gly Ile Asp Lys Pro Gln Cys Leu Ala Ala His
        1725                1730                1735

 cca gtc agg gga aaa ctc tac tgg acc gat gga aac aca att aac atg     6123
 Pro Val Arg Gly Lys Leu Tyr Trp Thr Asp Gly Asn Thr Ile Asn Met
    1740                1745                1750

 gca aat atg gat ggc agt aat agc aag att ctg ttt cag aat cag aag     6171
 Ala Asn Met Asp Gly Ser Asn Ser Lys Ile Leu Phe Gln Asn Gln Lys
1755                1760                1765                1770

 gag cca gtt ggt cta tcg ata gac tat gtg gaa aac aag ctt tat tgg     6219
 Glu Pro Val Gly Leu Ser Ile Asp Tyr Val Glu Asn Lys Leu Tyr Trp
                1775                1780                1785

 atc agt tcg ggg aat gga acc ata aat aga tgc aac ctg gat ggt ggt     6267
 Ile Ser Ser Gly Asn Gly Thr Ile Asn Arg Cys Asn Leu Asp Gly Gly
            1790                1795                1800

 aat tta gaa gta atc gag tca atg aaa gaa gaa tta aca aaa gct aca     6315
 Asn Leu Glu Val Ile Glu Ser Met Lys Glu Glu Leu Thr Lys Ala Thr
        1805                1810                1815

 gcc cta acc atc atg gat aag aaa ctg tgg tgg gca gac caa aac tta     6363
 Ala Leu Thr Ile Met Asp Lys Lys Leu Trp Trp Ala Asp Gln Asn Leu
    1820                1825                1830

 gcc cag cta gga acc tgc agc aaa aga gac gga aga aac ccc acc atc     6411
 Ala Gln Leu Gly Thr Cys Ser Lys Arg Asp Gly Arg Asn Pro Thr Ile
1835                1840                1845                1850

 cta cgg aat aag act tct ggg gta gtt cat atg aaa gtc tat gat aaa     6459
 Leu Arg Asn Lys Thr Ser Gly Val Val His Met Lys Val Tyr Asp Lys
                1855                1860                1865

 gaa gca cag caa ggc agc aat tcc tgc caa cta aac aat ggt gga tgc     6507
 Glu Ala Gln Gln Gly Ser Asn Ser Cys Gln Leu Asn Asn Gly Gly Cys
            1870                1875                1880

 tct caa ctt tgt tta cca aca tct gaa act aca agg act tgt atg tgt     6555
 Ser Gln Leu Cys Leu Pro Thr Ser Glu Thr Thr Arg Thr Cys Met Cys
        1885                1890                1895

 aca gtg gga tat tat ctc caa aag aac cgt atg tca tgt caa ggt ata     6603
 Thr Val Gly Tyr Tyr Leu Gln Lys Asn Arg Met Ser Cys Gln Gly Ile
    1900                1905                1910

 gaa tca ttt ctt atg tac tct gtt cat gaa gga atc agg gga ata cct     6651
 Glu Ser Phe Leu Met Tyr Ser Val His Glu Gly Ile Arg Gly Ile Pro
1915                1920                1925                1930

 ctt gaa cca agt gac aaa atg gat gct ttg atg cct ata tca gga act     6699
 Leu Glu Pro Ser Asp Lys Met Asp Ala Leu Met Pro Ile Ser Gly Thr
                1935                1940                1945

 tca ttt gcc gtg gga ata gat ttc cat gca gaa aat gat acc atc tac     6747
 Ser Phe Ala Val Gly Ile Asp Phe His Ala Glu Asn Asp Thr Ile Tyr
            1950                1955                1960

 tgg aca gac atg ggc ttc aat aaa att agc aga gct aaa aga gat cag     6795
 Trp Thr Asp Met Gly Phe Asn Lys Ile Ser Arg Ala Lys Arg Asp Gln
        1965                1970                1975

 act tgg aaa gaa gat atc att acc aat ggc ttg gga aga gtg gaa ggg     6843
 Thr Trp Lys Glu Asp Ile Ile Thr Asn Gly Leu Gly Arg Val Glu Gly
    1980                1985                1990

 ata gct gtt gac tgg att gct ggt aac ata tat tgg aca gat cat ggt     6891
 Ile Ala Val Asp Trp Ile Ala Gly Asn Ile Tyr Trp Thr Asp His Gly
1995                2000                2005                2010

 ttc aac tta att gaa gtt gca aga ctc aat ggt tct ttc cgt tat gta     6939
 Phe Asn Leu Ile Glu Val Ala Arg Leu Asn Gly Ser Phe Arg Tyr Val
                2015                2020                2025

 att att tcc caa ggc ctg gat caa cca aga tct ata gct gtg cac cca     6987
 Ile Ile Ser Gln Gly Leu Asp Gln Pro Arg Ser Ile Ala Val His Pro
            2030                2035                2040

 gag aaa ggc ctc ttg ttc tgg act gaa tgg gga caa atg ccc tgt att     7035
 Glu Lys Gly Leu Leu Phe Trp Thr Glu Trp Gly Gln Met Pro Cys Ile
        2045                2050                2055

 gga aag gct cgc ttg gat ggc tca gag aag gtt gtc ctt gta agc atg     7083
 Gly Lys Ala Arg Leu Asp Gly Ser Glu Lys Val Val Leu Val Ser Met
    2060                2065                2070

 gga ata gca tgg ccg aat ggc atc tcc atc gac tat gag gaa aat aaa     7131
 Gly Ile Ala Trp Pro Asn Gly Ile Ser Ile Asp Tyr Glu Glu Asn Lys
2075                2080                2085                2090

 ttg tac tgg tgt gat gct cgc aca gac aag ata gag aga atc gac ctt     7179
 Leu Tyr Trp Cys Asp Ala Arg Thr Asp Lys Ile Glu Arg Ile Asp Leu
                2095                2100                2105

 gag act gga ggg aat cgc gag atg gtg ctg tca gga agc aat gtg gat     7227
 Glu Thr Gly Gly Asn Arg Glu Met Val Leu Ser Gly Ser Asn Val Asp
            2110                2115                2120

 atg ttt tca gtt gca gtc ttt ggg gct tac atc tac tgg tct gac aga     7275
 Met Phe Ser Val Ala Val Phe Gly Ala Tyr Ile Tyr Trp Ser Asp Arg
        2125                2130                2135

 gca cat gca aac ggg tct gtc aga agg ggc cac aag aat gat gcc aca     7323
 Ala His Ala Asn Gly Ser Val Arg Arg Gly His Lys Asn Asp Ala Thr
    2140                2145                2150

 gaa acg ata acc atg aga acc ggc ctt gga gtc aac ctg aag gag gtt     7371
 Glu Thr Ile Thr Met Arg Thr Gly Leu Gly Val Asn Leu Lys Glu Val
2155                2160                2165                2170

 aaa ata ttt aac cga gta aga gag aaa ggg acc aat gtt tgt gcc agg     7419
 Lys Ile Phe Asn Arg Val Arg Glu Lys Gly Thr Asn Val Cys Ala Arg
                2175                2180                2185

 gac aat ggt ggc tgt aag caa ctc tgt ctt tat cga gga aat tcc cgg     7467
 Asp Asn Gly Gly Cys Lys Gln Leu Cys Leu Tyr Arg Gly Asn Ser Arg
            2190                2195                2200

 aga act tgt gct tgt gcc cat gga tat ttg gca gaa gat gga gtt act     7515
 Arg Thr Cys Ala Cys Ala His Gly Tyr Leu Ala Glu Asp Gly Val Thr
        2205                2210                2215

 tgc ctg agg cat gaa ggc tat tta ctg tat tca gga aga aca ata tta     7563
 Cys Leu Arg His Glu Gly Tyr Leu Leu Tyr Ser Gly Arg Thr Ile Leu
    2220                2225                2230

 aaa agt ata cat ctt tct gat gaa acc aat tta aat tcc cca ata agg     7611
 Lys Ser Ile His Leu Ser Asp Glu Thr Asn Leu Asn Ser Pro Ile Arg
2235                2240                2245                2250

 cca tat gag aat cca cgt tat ttc aag aat gtc ata gcc ttg gct ttt     7659
 Pro Tyr Glu Asn Pro Arg Tyr Phe Lys Asn Val Ile Ala Leu Ala Phe
                2255                2260                2265

 gac tat aat caa aga aga aaa ggt acc aac cga atc ttt tac agt gat     7707
 Asp Tyr Asn Gln Arg Arg Lys Gly Thr Asn Arg Ile Phe Tyr Ser Asp
            2270                2275                2280

 gca cac ttt gga aat ata cag ctt att aaa gac aac tgg gaa gac aga     7755
 Ala His Phe Gly Asn Ile Gln Leu Ile Lys Asp Asn Trp Glu Asp Arg
        2285                2290                2295

 caa gta att gtt gaa aat gtg ggt tct gtg gaa gga ctt gcc tat cac     7803
 Gln Val Ile Val Glu Asn Val Gly Ser Val Glu Gly Leu Ala Tyr His
    2300                2305                2310

 aga gcc tgg gat aca ctg tac tgg aca agc tct acc acc tca tcc atc     7851
 Arg Ala Trp Asp Thr Leu Tyr Trp Thr Ser Ser Thr Thr Ser Ser Ile
2315                2320                2325                2330

 acc aga cac act gtg gac cag act cgg cct gga gca ttt gac agg gaa     7899
 Thr Arg His Thr Val Asp Gln Thr Arg Pro Gly Ala Phe Asp Arg Glu
                2335                2340                2345

 gct gtc atc acc atg tca gaa gat gac cat cca cat gtg cta gcc ttg     7947
 Ala Val Ile Thr Met Ser Glu Asp Asp His Pro His Val Leu Ala Leu
            2350                2355                2360

 gat gaa tgt caa aat tta atg ttt tgg acc aac tgg aat gaa caa cat     7995
 Asp Glu Cys Gln Asn Leu Met Phe Trp Thr Asn Trp Asn Glu Gln His
        2365                2370                2375

 cca agt atc atg aga tct act ctg act ggg aaa aat gct caa gtg gtg     8043
 Pro Ser Ile Met Arg Ser Thr Leu Thr Gly Lys Asn Ala Gln Val Val
    2380                2385                2390

 gtc agt aca gac ata ctc act cca aat gga ctt act atc gac tac cgt     8091
 Val Ser Thr Asp Ile Leu Thr Pro Asn Gly Leu Thr Ile Asp Tyr Arg
2395                2400                2405                2410

 gca gag aag ctg tat ttc tca gat ggc agt cta gga aaa att gaa agg     8139
 Ala Glu Lys Leu Tyr Phe Ser Asp Gly Ser Leu Gly Lys Ile Glu Arg
                2415                2420                2425

 tgt gaa tac gat gga tcc cag aga cat gtg ata gtt aaa tct ggg cca     8187
 Cys Glu Tyr Asp Gly Ser Gln Arg His Val Ile Val Lys Ser Gly Pro
            2430                2435                2440

 ggg act ttc ctc agt ttg gct gtt tat gac aat tat ata ttc tgg tcg     8235
 Gly Thr Phe Leu Ser Leu Ala Val Tyr Asp Asn Tyr Ile Phe Trp Ser
        2445                2450                2455

 gac tgg gga aga aga gct ata ctg cgg tcc aac aag tac aca gga gga     8283
 Asp Trp Gly Arg Arg Ala Ile Leu Arg Ser Asn Lys Tyr Thr Gly Gly
    2460                2465                2470

 gat aca aaa att ctt cgt tcc gat att cca cat cag cca atg gga atc     8331
 Asp Thr Lys Ile Leu Arg Ser Asp Ile Pro His Gln Pro Met Gly Ile
2475                2480                2485                2490

 ata gct gtt gcc aat gac acc aat agc tgt gaa ctt tct cca tgt gca     8379
 Ile Ala Val Ala Asn Asp Thr Asn Ser Cys Glu Leu Ser Pro Cys Ala
                2495                2500                2505

 tta ttg aat gga ggc tgc cat gac ttg tgc ctt tta act ccc aat ggg     8427
 Leu Leu Asn Gly Gly Cys His Asp Leu Cys Leu Leu Thr Pro Asn Gly
            2510                2515                2520

 aga gtg aat tgt tcc tgc aga ggg gac cga ata ttg cta gag gac aac     8475
 Arg Val Asn Cys Ser Cys Arg Gly Asp Arg Ile Leu Leu Glu Asp Asn
        2525                2530                2535

 aga tgt gtg act aaa aat tcc tcc tgc aac gct tat tcg gag ttt gaa     8523
 Arg Cys Val Thr Lys Asn Ser Ser Cys Asn Ala Tyr Ser Glu Phe Glu
    2540                2545                2550

 tgt gga aat ggt gag tgc att gac tac cag ctc acc tgt gat ggc att     8571
 Cys Gly Asn Gly Glu Cys Ile Asp Tyr Gln Leu Thr Cys Asp Gly Ile
2555                2560                2565                2570

 cct cac tgt aaa gat aaa tca gat gaa aaa ctg ctc tac tgt gaa aac     8619
 Pro His Cys Lys Asp Lys Ser Asp Glu Lys Leu Leu Tyr Cys Glu Asn
                2575                2580                2585

 aga agc tgt cga aga ggc ttc aag cca tgc tat aat cgc cgc tgc att     8667
 Arg Ser Cys Arg Arg Gly Phe Lys Pro Cys Tyr Asn Arg Arg Cys Ile
            2590                2595                2600

 cct cat ggc aag tta tgt gat gga gaa aat gac tgc gga gac aac tct     8715
 Pro His Gly Lys Leu Cys Asp Gly Glu Asn Asp Cys Gly Asp Asn Ser
        2605                2610                2615

 gat gaa tta gat tgt aaa gtt tca acc tgt gcc acg gtt gag ttc cgc     8763
 Asp Glu Leu Asp Cys Lys Val Ser Thr Cys Ala Thr Val Glu Phe Arg
    2620                2625                2630

 tgt gca gat ggg act tgt att cca aga tca gca cga tgc aac cag aac     8811
 Cys Ala Asp Gly Thr Cys Ile Pro Arg Ser Ala Arg Cys Asn Gln Asn
2635                2640                2645                2650

 ata gat tgt gca gat gct tca gat gaa aag aac tgc aat aac aca gac     8859
 Ile Asp Cys Ala Asp Ala Ser Asp Glu Lys Asn Cys Asn Asn Thr Asp
                2655                2660                2665

 tgc aca cat ttc tat aag ctt gga gtg aaa acc aca ggg ttc ata aga     8907
 Cys Thr His Phe Tyr Lys Leu Gly Val Lys Thr Thr Gly Phe Ile Arg
            2670                2675                2680

 tgt aat tct acc tca ctg tgt gtt ctg cca acc tgg ata tgc gac ggg     8955
 Cys Asn Ser Thr Ser Leu Cys Val Leu Pro Thr Trp Ile Cys Asp Gly
        2685                2690                2695

 tct aat gac tgt gga gac tat tca gat gaa tta aag tgc cca gtt cag     9003
 Ser Asn Asp Cys Gly Asp Tyr Ser Asp Glu Leu Lys Cys Pro Val Gln
    2700                2705                2710

 aac aaa cac aaa tgt gaa gaa aat tat ttt agt tgt cct agt gga aga     9051
 Asn Lys His Lys Cys Glu Glu Asn Tyr Phe Ser Cys Pro Ser Gly Arg
2715                2720                2725                2730

 tgc att ttg aat acc tgg ata tgc gat ggt cag aaa gat tgt gag gat     9099
 Cys Ile Leu Asn Thr Trp Ile Cys Asp Gly Gln Lys Asp Cys Glu Asp
                2735                2740                2745

 gga cgt gat gaa ttc cac tgt gat tct tct tgc tct tgg aac caa ttt     9147
 Gly Arg Asp Glu Phe His Cys Asp Ser Ser Cys Ser Trp Asn Gln Phe
            2750                2755                2760

 gct tgt tcc gca caa aaa tgt att tct aag cat tgg att tgt gat gga     9195
 Ala Cys Ser Ala Gln Lys Cys Ile Ser Lys His Trp Ile Cys Asp Gly
        2765                2770                2775

 gaa gat gac tgt ggg gat ggg tta gat gaa agt gac agc att tgt ggt     9243
 Glu Asp Asp Cys Gly Asp Gly Leu Asp Glu Ser Asp Ser Ile Cys Gly
    2780                2785                2790

 gcc ata acc tgt gct gct gac atg ttc agc tgc cag ggc tct cgt gcc     9291
 Ala Ile Thr Cys Ala Ala Asp Met Phe Ser Cys Gln Gly Ser Arg Ala
2795                2800                2805                2810

 tgc gtg ccc cga cat tgg ctt tgt gat ggt gaa agg gac tgt cca gat     9339
 Cys Val Pro Arg His Trp Leu Cys Asp Gly Glu Arg Asp Cys Pro Asp
                2815                2820                2825

 gga agc gat gag ctt tcc aca gca ggc tgc gct ccc aat aat aca tgt     9387
 Gly Ser Asp Glu Leu Ser Thr Ala Gly Cys Ala Pro Asn Asn Thr Cys
            2830                2835                2840

 gat gaa aat gct ttc atg tgc cat aat aaa gta tgc att ccc aag caa     9435
 Asp Glu Asn Ala Phe Met Cys His Asn Lys Val Cys Ile Pro Lys Gln
        2845                2850                2855

 ttt gtt tgt gac cat gat gac gac tgt gga gat ggc tct gat gag tca     9483
 Phe Val Cys Asp His Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu Ser
    2860                2865                2870

 ccg cag tgt gga tac cga cag tgt ggt aca gaa gaa ttt agt tgt gct     9531
 Pro Gln Cys Gly Tyr Arg Gln Cys Gly Thr Glu Glu Phe Ser Cys Ala
2875                2880                2885                2890

 gat ggg cgg tgt ctt cta aat act caa tgg cag tgt gat gga gac ttt     9579
 Asp Gly Arg Cys Leu Leu Asn Thr Gln Trp Gln Cys Asp Gly Asp Phe
                2895                2900                2905

 gac tgt cct gac cat tct gat gaa gca cct tta aac cca aag tgt aaa     9627
 Asp Cys Pro Asp His Ser Asp Glu Ala Pro Leu Asn Pro Lys Cys Lys
            2910                2915                2920

 agt gca gaa cag tca tgc aac agt tca ttt ttt atg tgc aaa aat ggc     9675
 Ser Ala Glu Gln Ser Cys Asn Ser Ser Phe Phe Met Cys Lys Asn Gly
        2925                2930                2935

 agg tgc att ccc agt gga ggt ctt tgt gac aat aag gat gac tgt ggc     9723
 Arg Cys Ile Pro Ser Gly Gly Leu Cys Asp Asn Lys Asp Asp Cys Gly
    2940                2945                2950

 gat ggt tca gat gag aga aac tgc cat ata aat gaa tgt ttg agt aag     9771
 Asp Gly Ser Asp Glu Arg Asn Cys His Ile Asn Glu Cys Leu Ser Lys
2955                2960                2965                2970

 aaa gtc agt gga tgt tct caa gat tgt caa gac ctt ccg gtc agt tat     9819
 Lys Val Ser Gly Cys Ser Gln Asp Cys Gln Asp Leu Pro Val Ser Tyr
                2975                2980                2985

 aag tgc aaa tgc tgg cct gga ttc caa ctg aag gat gac ggc aaa aca     9867
 Lys Cys Lys Cys Trp Pro Gly Phe Gln Leu Lys Asp Asp Gly Lys Thr
            2990                2995                3000

 tgt gta gac att gat gaa tgc tct tca ggc ttt ccc tgt agc cag caa     9915
 Cys Val Asp Ile Asp Glu Cys Ser Ser Gly Phe Pro Cys Ser Gln Gln
        3005                3010                3015

 tgc atc aat aca tac ggg act tac aag tgc ctc tgt aca gat ggg tat     9963
 Cys Ile Asn Thr Tyr Gly Thr Tyr Lys Cys Leu Cys Thr Asp Gly Tyr
    3020                3025                3030

 gaa ata caa cct gat aac cca aat ggc tgc aaa tcg ctc tca gat gaa    10011
 Glu Ile Gln Pro Asp Asn Pro Asn Gly Cys Lys Ser Leu Ser Asp Glu
3035                3040                3045                3050

 gaa cct ttt tta att ctt gct gat cat cat gag ata agg aaa att agc    10059
 Glu Pro Phe Leu Ile Leu Ala Asp His His Glu Ile Arg Lys Ile Ser
                3055                3060                3065

 act gat ggc tcc aac tac aca ctt tta aaa cag gga tta aac aat gtt    10107
 Thr Asp Gly Ser Asn Tyr Thr Leu Leu Lys Gln Gly Leu Asn Asn Val
            3070                3075                3080

 att gct ata gac ttt gat tac aga gaa gaa ttc atc tat tgg atc gat    10155
 Ile Ala Ile Asp Phe Asp Tyr Arg Glu Glu Phe Ile Tyr Trp Ile Asp
        3085                3090                3095

 tct agc cga ccc aat ggc agt cgc ata aat aga atg tgt tta aat gga    10203
 Ser Ser Arg Pro Asn Gly Ser Arg Ile Asn Arg Met Cys Leu Asn Gly
    3100                3105                3110

 agt gac att aag gta gtt cat aac aca gcg gtc ccc aat gca ctt gct    10251
 Ser Asp Ile Lys Val Val His Asn Thr Ala Val Pro Asn Ala Leu Ala
3115                3120                3125                3130

 gtc gat tgg att gga aaa aac ctc tat tgg tct gac aca gaa aaa aga    10299
 Val Asp Trp Ile Gly Lys Asn Leu Tyr Trp Ser Asp Thr Glu Lys Arg
                3135                3140                3145

 atc att gaa gta tcc aaa ctc aat ggc ttg tac cct act ata ctc gtt    10347
 Ile Ile Glu Val Ser Lys Leu Asn Gly Leu Tyr Pro Thr Ile Leu Val
            3150                3155                3160

 agc aaa agg ctg aag ttt ccc aga gac ttg tct tta gat cct caa gct    10395
 Ser Lys Arg Leu Lys Phe Pro Arg Asp Leu Ser Leu Asp Pro Gln Ala
        3165                3170                3175

 gga tat ttg tat tgg att gac tgc tgc gag tat cct cat att ggc cgt    10443
 Gly Tyr Leu Tyr Trp Ile Asp Cys Cys Glu Tyr Pro His Ile Gly Arg
    3180                3185                3190

 gtt gga atg gat gga acc aat cag agt gtt gtc ata gaa acc aag att    10491
 Val Gly Met Asp Gly Thr Asn Gln Ser Val Val Ile Glu Thr Lys Ile
3195                3200                3205                3210

 tct aga cct atg gca cta aca ata gat tat gtt aat cgt aga ctc tac    10539
 Ser Arg Pro Met Ala Leu Thr Ile Asp Tyr Val Asn Arg Arg Leu Tyr
                3215                3220                3225

 tgg gcc gat gaa aat cac att gaa ttt agc aac atg gat gga tct cat    10587
 Trp Ala Asp Glu Asn His Ile Glu Phe Ser Asn Met Asp Gly Ser His
            3230                3235                3240

 aga cac aaa gtc cct aat caa gat att cca ggg gtg att gca cta aca    10635
 Arg His Lys Val Pro Asn Gln Asp Ile Pro Gly Val Ile Ala Leu Thr
        3245                3250                3255

 ttg ttt gaa gac tac atc tac tgg act gat ggg aaa acc aag tca ctc    10683
 Leu Phe Glu Asp Tyr Ile Tyr Trp Thr Asp Gly Lys Thr Lys Ser Leu
    3260                3265                3270

 agc cgt gcc cat aaa aca tcg gga gca gac aga ctc tca ctg att tac    10731
 Ser Arg Ala His Lys Thr Ser Gly Ala Asp Arg Leu Ser Leu Ile Tyr
3275                3280                3285                3290

 tca tgg cat gcc atc aca gat atc cag gtg tat cat tct tat aga caa    10779
 Ser Trp His Ala Ile Thr Asp Ile Gln Val Tyr His Ser Tyr Arg Gln
                3295                3300                3305

 cct gat gtc tcc aaa cat ctc tgc atg ata aat aat ggt ggt tgc agt    10827
 Pro Asp Val Ser Lys His Leu Cys Met Ile Asn Asn Gly Gly Cys Ser
            3310                3315                3320

 cat ttg tgc ctt tta gcc cct gga aaa acc cac act tgt gca tgt ccc    10875
 His Leu Cys Leu Leu Ala Pro Gly Lys Thr His Thr Cys Ala Cys Pro
        3325                3330                3335

 act aac ttc tat ctg gca gct gat aat agg act tgc tta tcc aac tgc    10923
 Thr Asn Phe Tyr Leu Ala Ala Asp Asn Arg Thr Cys Leu Ser Asn Cys
    3340                3345                3350

 aca gcc agc cag ttt cgt tgc aaa act gac aaa tgt att cca ttc tgg    10971
 Thr Ala Ser Gln Phe Arg Cys Lys Thr Asp Lys Cys Ile Pro Phe Trp
3355                3360                3365                3370

 tgg aaa tgt gac acc gtg gat gac tgt ggt gat gga tct gat gaa cct    11019
 Trp Lys Cys Asp Thr Val Asp Asp Cys Gly Asp Gly Ser Asp Glu Pro
                3375                3380                3385

 gat gac tgt cct gaa ttt aga tgt cag cca ggc cga ttt cag tgt ggg    11067
 Asp Asp Cys Pro Glu Phe Arg Cys Gln Pro Gly Arg Phe Gln Cys Gly
            3390                3395                3400

 act gga ctc tgt gct cta cca gct ttc atc tgt gat gga gag aat gat    11115
 Thr Gly Leu Cys Ala Leu Pro Ala Phe Ile Cys Asp Gly Glu Asn Asp
        3405                3410                3415

 tgt gga gac aat tct gat gaa ctc aac tgt gac aca cat gtc tgc ctg    11163
 Cys Gly Asp Asn Ser Asp Glu Leu Asn Cys Asp Thr His Val Cys Leu
    3420                3425                3430

 tca ggt caa ttc aaa tgt acc aag aac cag aaa tgt atc cca gta aac    11211
 Ser Gly Gln Phe Lys Cys Thr Lys Asn Gln Lys Cys Ile Pro Val Asn
3435                3440                3445                3450

 tta aga tgt aat ggg caa gat gac tgt ggt gat gag gaa gat gaa aga    11259
 Leu Arg Cys Asn Gly Gln Asp Asp Cys Gly Asp Glu Glu Asp Glu Arg
                3455                3460                3465

 gac tgt cct gaa aac agc tgt tct cca gac tat ttc cag tgt aag act    11307
 Asp Cys Pro Glu Asn Ser Cys Ser Pro Asp Tyr Phe Gln Cys Lys Thr
            3470                3475                3480

 acg aag cat tgc att tcc aag ctg tgg gtt tgt gac gag gat cca gac    11355
 Thr Lys His Cys Ile Ser Lys Leu Trp Val Cys Asp Glu Asp Pro Asp
        3485                3490                3495

 tgt gca gat gca tca gac gag gcc aac tgc gat aaa aag act tgt gga    11403
 Cys Ala Asp Ala Ser Asp Glu Ala Asn Cys Asp Lys Lys Thr Cys Gly
    3500                3505                3510

 cct cat gaa ttc cag tgt aaa aac aac aac tgt att ccc gat cac tgg    11451
 Pro His Glu Phe Gln Cys Lys Asn Asn Asn Cys Ile Pro Asp His Trp
3515                3520                3525                3530

 cgg tgt gat agc caa aat gac tgc agt gat aat tca gat gaa gaa aac    11499
 Arg Cys Asp Ser Gln Asn Asp Cys Ser Asp Asn Ser Asp Glu Glu Asn
                3535                3540                3545

 tgt aag cca cag aca tgt aca ttg aaa gat ttc ctc tgt gcc aat ggg    11547
 Cys Lys Pro Gln Thr Cys Thr Leu Lys Asp Phe Leu Cys Ala Asn Gly
            3550                3555                3560

 gac tgt gtt tct tca agg ttt tgg tgt gat gga gat ttt gac tgt gca    11595
 Asp Cys Val Ser Ser Arg Phe Trp Cys Asp Gly Asp Phe Asp Cys Ala
        3565                3570                3575

 gat ggc tct gat gag aga aat tgt gag aca agt tgt tcc aaa gat cag    11643
 Asp Gly Ser Asp Glu Arg Asn Cys Glu Thr Ser Cys Ser Lys Asp Gln
    3580                3585                3590

 ttc cgg tgt tcc aat ggt cag tgt ata cca gca aaa tgg aaa tgt gat    11691
 Phe Arg Cys Ser Asn Gly Gln Cys Ile Pro Ala Lys Trp Lys Cys Asp
3595                3600                3605                3610

 ggc cat gaa gac tgc aaa tat ggg gaa gat gag aaa agc tgt gag cca    11739
 Gly His Glu Asp Cys Lys Tyr Gly Glu Asp Glu Lys Ser Cys Glu Pro
                3615                3620                3625

 gct tct cct act tgc tca tca cgt gaa tat ata tgt gcc agt gat gga    11787
 Ala Ser Pro Thr Cys Ser Ser Arg Glu Tyr Ile Cys Ala Ser Asp Gly
            3630                3635                3640

 tgt att tca gca tct ttg aaa tgt aat gga gaa tat gat tgt gct gat    11835
 Cys Ile Ser Ala Ser Leu Lys Cys Asn Gly Glu Tyr Asp Cys Ala Asp
        3645                3650                3655

 ggt tca gat gag atg gac tgt gtg act gaa tgt aag gaa gat cag ttt    11883
 Gly Ser Asp Glu Met Asp Cys Val Thr Glu Cys Lys Glu Asp Gln Phe
    3660                3665                3670

 cgg tgc aaa aat aaa gcc cac tgt att cca att aga tgg ctg tgt gat    11931
 Arg Cys Lys Asn Lys Ala His Cys Ile Pro Ile Arg Trp Leu Cys Asp
3675                3680                3685                3690

 gga att cat gac tgt gtg gat ggc agt gat gaa gag aac tgt gaa aga    11979
 Gly Ile His Asp Cys Val Asp Gly Ser Asp Glu Glu Asn Cys Glu Arg
                3695                3700                3705

 gga gga aat ata tgt aga gct gat gag ttc ctt tgc aat aat tct ctc    12027
 Gly Gly Asn Ile Cys Arg Ala Asp Glu Phe Leu Cys Asn Asn Ser Leu
            3710                3715                3720

 tgc aaa cta cat ttc tgg gtg tgt gat gga gag gac gac tgt gga gac    12075
 Cys Lys Leu His Phe Trp Val Cys Asp Gly Glu Asp Asp Cys Gly Asp
        3725                3730                3735

 aac tct gat gaa gcc cct gat atg tgt gtc aaa ttt ctt tgt cca tcc    12123
 Asn Ser Asp Glu Ala Pro Asp Met Cys Val Lys Phe Leu Cys Pro Ser
    3740                3745                3750

 acg aga cct cac aga tgc aga aat aac aga ata tgc cta cag tcg gag    12171
 Thr Arg Pro His Arg Cys Arg Asn Asn Arg Ile Cys Leu Gln Ser Glu
3755                3760                3765                3770

 caa atg tgc aat ggg att gat gaa tgc ggt gac aat tca gat gaa gat    12219
 Gln Met Cys Asn Gly Ile Asp Glu Cys Gly Asp Asn Ser Asp Glu Asp
                3775                3780                3785

 cac tgt ggt ggt aag ctg aca tat aaa gca agg cct tgt aaa aag gat    12267
 His Cys Gly Gly Lys Leu Thr Tyr Lys Ala Arg Pro Cys Lys Lys Asp
            3790                3795                3800

 gag ttt gct tgt agt aat aaa aaa tgc atc cct atg gat ctc cag tgt    12315
 Glu Phe Ala Cys Ser Asn Lys Lys Cys Ile Pro Met Asp Leu Gln Cys
        3805                3810                3815

 gat cga ctt gat gac tgc gga gat ggt tca gat gag caa gga tgc aga    12363
 Asp Arg Leu Asp Asp Cys Gly Asp Gly Ser Asp Glu Gln Gly Cys Arg
    3820                3825                3830

 ata gct cct act gaa tat acc tgt gaa gat aat gtg aat cca tgt gga    12411
 Ile Ala Pro Thr Glu Tyr Thr Cys Glu Asp Asn Val Asn Pro Cys Gly
3835                3840                3845                3850

 gat gat gca tat tgt aat caa ata aaa aca tct gtt ttc tgt cgc tgt    12459
 Asp Asp Ala Tyr Cys Asn Gln Ile Lys Thr Ser Val Phe Cys Arg Cys
                3855                3860                3865

 aag cct gga ttt cag aga aac atg aaa aac aga caa tgt gaa gac ctt    12507
 Lys Pro Gly Phe Gln Arg Asn Met Lys Asn Arg Gln Cys Glu Asp Leu
            3870                3875                3880

 aat gaa tgt ttg gtg ttt ggc aca tgt tcc cat caa tgt ata aat gtg    12555
 Asn Glu Cys Leu Val Phe Gly Thr Cys Ser His Gln Cys Ile Asn Val
        3885                3890                3895

 gaa gga tca tat aaa tgt gtg tgt gac cag aat ttt caa gaa aga aat    12603
 Glu Gly Ser Tyr Lys Cys Val Cys Asp Gln Asn Phe Gln Glu Arg Asn
    3900                3905                3910

 aac acc tgc ata gca gaa ggc tct gaa gat caa gtt ctc tac att gct    12651
 Asn Thr Cys Ile Ala Glu Gly Ser Glu Asp Gln Val Leu Tyr Ile Ala
3915                3920                3925                3930

 aat gac act gat atc ctg ggt ttt ata tat cca ttc aac tac agt ggc    12699
 Asn Asp Thr Asp Ile Leu Gly Phe Ile Tyr Pro Phe Asn Tyr Ser Gly
                3935                3940                3945

 gat cat caa caa att tct cat att gaa cat aat tca aga ata aca ggg    12747
 Asp His Gln Gln Ile Ser His Ile Glu His Asn Ser Arg Ile Thr Gly
            3950                3955                3960

 atg gat gta tat tat caa aga gat atg att att tgg agt act cag ttt    12795
 Met Asp Val Tyr Tyr Gln Arg Asp Met Ile Ile Trp Ser Thr Gln Phe
        3965                3970                3975

 aat cca ggc gga att ttc tac aaa agg atc cat ggc aga gaa aaa agg    12843
 Asn Pro Gly Gly Ile Phe Tyr Lys Arg Ile His Gly Arg Glu Lys Arg
    3980                3985                3990

 caa gca aac agt ggc ttg att tgt cct gaa ttt aaa agg ccc agg gac    12891
 Gln Ala Asn Ser Gly Leu Ile Cys Pro Glu Phe Lys Arg Pro Arg Asp
3995                4000                4005                4010

 att gca gtt gac tgg gtg gct gga aac att tac tgg act gat cat tct    12939
 Ile Ala Val Asp Trp Val Ala Gly Asn Ile Tyr Trp Thr Asp His Ser
                4015                4020                4025

 aga atg cat tgg ttc agt tac tac act act cac tgg acc agt ctg agg    12987
 Arg Met His Trp Phe Ser Tyr Tyr Thr Thr His Trp Thr Ser Leu Arg
            4030                4035                4040

 tac tct atc aac gta ggg cag ctg aat ggc ccc aac tgc acc aga ctc    13035
 Tyr Ser Ile Asn Val Gly Gln Leu Asn Gly Pro Asn Cys Thr Arg Leu
        4045                4050                4055

 tta aca aat atg gct gga gaa ccc tat gct att gca gta aat cct aaa    13083
 Leu Thr Asn Met Ala Gly Glu Pro Tyr Ala Ile Ala Val Asn Pro Lys
    4060                4065                4070

 aga ggg atg atg tac tgg act gtt gtt ggg gat cat tcc cat ata gaa    13131
 Arg Gly Met Met Tyr Trp Thr Val Val Gly Asp His Ser His Ile Glu
4075                4080                4085                4090

 gaa gca gcc atg gat ggt aca ctg aga agg att tta gta caa aag aac    13179
 Glu Ala Ala Met Asp Gly Thr Leu Arg Arg Ile Leu Val Gln Lys Asn
                4095                4100                4105

 tta cag aga ccc aca ggt ttg gct gtg gat tat ttt agt gaa cgc ata    13227
 Leu Gln Arg Pro Thr Gly Leu Ala Val Asp Tyr Phe Ser Glu Arg Ile
            4110                4115                4120

 tat tgg gct gac ttt gag ctc tcc atc att ggc agt gtt ctg tat gat    13275
 Tyr Trp Ala Asp Phe Glu Leu Ser Ile Ile Gly Ser Val Leu Tyr Asp
        4125                4130                4135

 ggc tct aat tca gta gtc tct gtc agc agc aaa caa ggt tta tta cat    13323
 Gly Ser Asn Ser Val Val Ser Val Ser Ser Lys Gln Gly Leu Leu His
    4140                4145                4150

 cca cat agg atc gat atc ttt gaa gat tat ata tat gga gca gga cct    13371
 Pro His Arg Ile Asp Ile Phe Glu Asp Tyr Ile Tyr Gly Ala Gly Pro
4155                4160                4165                4170

 aaa aat ggt gta ttt cga gtt caa aaa ttt ggc cat ggt tca gta gag    13419
 Lys Asn Gly Val Phe Arg Val Gln Lys Phe Gly His Gly Ser Val Glu
                4175                4180                4185

 tac tta gct tta aat att gat aaa aca aaa ggt gtt ttg ata tct cat    13467
 Tyr Leu Ala Leu Asn Ile Asp Lys Thr Lys Gly Val Leu Ile Ser His
            4190                4195                4200

 cgt tat aaa caa cta gat tta ccc aat cca tgc ttg gat tta gca tgc    13515
 Arg Tyr Lys Gln Leu Asp Leu Pro Asn Pro Cys Leu Asp Leu Ala Cys
        4205                4210                4215

 gaa ttt ctt tgc ttg cta aat cct tct ggg gcc act tgt gtg tgt cca    13563
 Glu Phe Leu Cys Leu Leu Asn Pro Ser Gly Ala Thr Cys Val Cys Pro
    4220                4225                4230

 gaa gga aaa tat ttg att aat ggc acc tgc aat gat gac agc ctg tta    13611
 Glu Gly Lys Tyr Leu Ile Asn Gly Thr Cys Asn Asp Asp Ser Leu Leu
4235                4240                4245                4250

 gat gat tca tgt aag tta act tgt gaa aat gga gga aga tgc att tta    13659
 Asp Asp Ser Cys Lys Leu Thr Cys Glu Asn Gly Gly Arg Cys Ile Leu
                4255                4260                4265

 aat gag aaa ggt gat ttg agg tgt cac tgt tgg ccc agt tat tca gga    13707
 Asn Glu Lys Gly Asp Leu Arg Cys His Cys Trp Pro Ser Tyr Ser Gly
            4270                4275                4280

 gaa aga tgt gaa gtc aac cac tgt agc aac tac tgc cag aat gga gga    13755
 Glu Arg Cys Glu Val Asn His Cys Ser Asn Tyr Cys Gln Asn Gly Gly
        4285                4290                4295

 act tgc gta cca tca gtt cta ggg aga ccc acc tgc agc tgt gca ctg    13803
 Thr Cys Val Pro Ser Val Leu Gly Arg Pro Thr Cys Ser Cys Ala Leu
    4300                4305                4310

 ggt ttc act ggg cca aac tgt ggt aag aca gtc tgt gag gat ttt tgt    13851
 Gly Phe Thr Gly Pro Asn Cys Gly Lys Thr Val Cys Glu Asp Phe Cys
4315                4320                4325                4330

 caa aat gga gga acc tgc att gtg act gct gga aac cag cct tac tgc    13899
 Gln Asn Gly Gly Thr Cys Ile Val Thr Ala Gly Asn Gln Pro Tyr Cys
                4335                4340                4345

 cac tgc cag ccg gaa tac acc gga gac aga tgt cag tac tac gtg tgc    13947
 His Cys Gln Pro Glu Tyr Thr Gly Asp Arg Cys Gln Tyr Tyr Val Cys
            4350                4355                4360

 cac cac tat tgt gtg aat tct gaa tca tgt acc att ggg gat gat gga    13995
 His His Tyr Cys Val Asn Ser Glu Ser Cys Thr Ile Gly Asp Asp Gly
        4365                4370                4375

 agt ctt gaa tgt gtc tgt cca acg cgc tat gaa gga cca aaa tgt gag    14043
 Ser Leu Glu Cys Val Cys Pro Thr Arg Tyr Glu Gly Pro Lys Cys Glu
    4380                4385                4390

 gtt gac aag tgt gta agg tgc cat ggg ggg cac tgc att ata aat aaa    14091
 Val Asp Lys Cys Val Arg Cys His Gly Gly His Cys Ile Ile Asn Lys
4395                4400                4405                4410

 gac agt gaa gat ata ttt tgc aac tgc act aat gga aag att gcc tct    14139
 Asp Ser Glu Asp Ile Phe Cys Asn Cys Thr Asn Gly Lys Ile Ala Ser
                4415                4420                4425

 agc tgt cag tta tgt gat ggc tac tgt tac aat ggt ggc aca tgc cag    14187
 Ser Cys Gln Leu Cys Asp Gly Tyr Cys Tyr Asn Gly Gly Thr Cys Gln
            4430                4435                4440

 ctg gac ccc gag aca aat gta cct gtg tgt cta tgc tcc acc aac tgg    14235
 Leu Asp Pro Glu Thr Asn Val Pro Val Cys Leu Cys Ser Thr Asn Trp
        4445                4450                4455

 tca ggc aca cag tgt gaa agg cca gcc cca aag agc agc aag tct gat    14283
 Ser Gly Thr Gln Cys Glu Arg Pro Ala Pro Lys Ser Ser Lys Ser Asp
    4460                4465                4470

 cat atc agc aca aga agc att gcc atc att gtg cct ctc gtc ctc ttg    14331
 His Ile Ser Thr Arg Ser Ile Ala Ile Ile Val Pro Leu Val Leu Leu
4475                4480                4485                4490

 gtg act ttg ata acc acc tta gta att ggt tta gtg ctt tgt aaa aga    14379
 Val Thr Leu Ile Thr Thr Leu Val Ile Gly Leu Val Leu Cys Lys Arg
                4495                4500                4505

 aaa aga agg aca aaa aca att aga aga caa cct att atc aat gga gga    14427
 Lys Arg Arg Thr Lys Thr Ile Arg Arg Gln Pro Ile Ile Asn Gly Gly
            4510                4515                4520

 ata aat gta gaa att ggc aat cca tct tat aac atg tat gag gta gat    14475
 Ile Asn Val Glu Ile Gly Asn Pro Ser Tyr Asn Met Tyr Glu Val Asp
        4525                4530                4535

 cat gat cac aac gat gga ggt ctt tta gat cct ggc ttt atg ata gac    14523
 His Asp His Asn Asp Gly Gly Leu Leu Asp Pro Gly Phe Met Ile Asp
    4540                4545                4550

 cca aca aag gcc agg tac ata ggg gga gga ccc agt gct ttc aag ctt    14571
 Pro Thr Lys Ala Arg Tyr Ile Gly Gly Gly Pro Ser Ala Phe Lys Leu
4555                4560                4565                4570

 cca cac aca gcg ccg ccc atc tac cta aac tct gat ttg aaa gga cca    14619
 Pro His Thr Ala Pro Pro Ile Tyr Leu Asn Ser Asp Leu Lys Gly Pro
                4575                4580                4585

 cta act gct ggg cca aca aat tac tcc aat ccg gta tat gca aaa tta    14667
 Leu Thr Ala Gly Pro Thr Asn Tyr Ser Asn Pro Val Tyr Ala Lys Leu
            4590                4595                4600

 tat atg gat ggg caa aac tgt cga aac tcc tta gga agt gtt gat gaa    14715
 Tyr Met Asp Gly Gln Asn Cys Arg Asn Ser Leu Gly Ser Val Asp Glu
        4605                4610                4615

 agg aaa gaa ctg ctt cca aag aaa ata gaa att ggt ata aga gag aca    14763
 Arg Lys Glu Leu Leu Pro Lys Lys Ile Glu Ile Gly Ile Arg Glu Thr
    4620                4625                4630

 gtg gca taa tcagtga tatcttttat atgctgtata aatgtataag aatattagga    14819
 Val Ala 
4635

 gtacatttgg tatgtcccaa caggtattat acgtggttgg catcagcatt acctctttct  14879

 ttatcttttt cctggttaat tgttttctga gttttttggg ttttattttt tgctgatgac  14939

 tattgattga ccatttgtat ggtattttta tgaaaaagaa ctgcactaca gtacaattta  14999

 caacaatgct gctgatatga cacacctttg aatttgttaa aattaaaaac aacgtattcc  15059

 tttgtagtgt gaatatgagc aatctatttt atatgaactt ttttggttgt acttaatcaa  15119

 cgaggagaat ctctgcactt ttccattata cggtttgaag gctgtaatac agtgtcattt  15179

 tatttttctg tttaaattga tggaaaaatg attgaatggt caactctctt ctttgtgccc  15239

 ataaagatcg attcagactc tgctgaaaat atatagctct cacaagttca gcatcacctg  15299

 ctttgaaatt agccttagat tgccaaccaa tagatgagaa ttttgaggaa aaaaattaaa  15359

 aatatgtaaa attaataatt tgcatgaaca cagatgacta cattttccaa aacttagtgg  15419

 actctatgtg atgtactaaa tgtatacacc ttgtaagcaa tagttatatt taggtggtag  15479

 aacatagcaa aaatataacc gaaagttggc cgactgcact tgctatggaa taagaccttt  15539

 tattctccct cagtctcgag ataaatagcc agcctagagc acaacagggc attgggtact  15599

 tgcatcttag gtatttcttc ccagtcacat ccattttgtg gaagattaac ccaacccctt  15659

 acactacact gaacactaaa gaataacata taagcacaca aattggtgac agaatttcaa  15719

 ttacgtgaac gcatcctctt tgctaggtca aaaacaaagg gcaaagcaga cattttagta  15779

 tacagagtga ttggcaaata ttttcaagat ttaatatgag caacccatta tttgccctat  15839

 ccaaaatata ttcaagggcc ttccaagttg tagaagaaca atgatcttcc cataatcaaa  15899

 agtggagagt cgaaatgctg tgccagttgc tctggtattc aggtttctct gggttttaca  15959

 gaacgcatgg accccattca cgtttggttt gtttatcttc aaatttgagt tgaaacgagt  16019

 gcgatttatt taagttgtat ataaaaataa aaggatagca tttttataca aatatcttta  16079

 aaggcacaaa agatttattc acaagttttg gagggctttt tgttcctctg atagacatga  16139

 ctgactttta gctgtcataa tgtattaacc taacagatga aatatgttaa atatgtggtt  16199

 gctctttatc cctttgtaca agcattaaaa aaactgctgt tttataagaa gactttttgt  16259

 tgtactatgt gcatgcatac tacctatttc taaactttgc catattgagg cctttataaa  16319

 ctattgattt atgtaatact agtgcaattt tgcttgaaca atgttatgca tatcataaac  16379

 tttttcaggt tcttgtttaa gtacattttt taaattgaac agtatttttc attttggtta  16439

 taatatagtc attttgccta tgtttctaca atgaagtgtt aaatacttta taaaaaattg  16499

 ttgactgact tatttaaatg aaattctaca tatttaaaaa aaaaaa                 16545




      <210> 28
      <211> 1144
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (149)..(727)

      <220>
      <221> misc_feature
      <222> (1)...(1144)
      <223> n = a,t,c or g

      <400> 28
 cacacgggcg cctcgctcgc gctcacacac gctctgcctc ctctctcccg cacgcgcgca     60

 tccctccacc ttccacatcc tgctccaggc aggagaaggc tgactggctg gactcattga    120

 gctgaagaat ttccagtgac atttgtaa   atg acg ccg ctc gat tcc agg ctc     172
                                  Met Thr Pro Leu Asp Ser Arg Leu
                                    1               5

 caa gcg gcc cct gcc gcc gcc gcc gcc gcc ggg ccg aag gtg ccg ccg      220
 Gln Ala Ala Pro Ala Ala Ala Ala Ala Ala Gly Pro Lys Val Pro Pro
      10                  15                  20

 agc agt ctc cag cgc agg ctt cct tac cgg gcg acc aca atg tcc gag      268
 Ser Ser Leu Gln Arg Arg Leu Pro Tyr Arg Ala Thr Thr Met Ser Glu
  25                  30                  35                  40

 ttt ctc ctc gcc tta ctc act ctc tcg gga tta ttg ccg att gcc agg      316
 Phe Leu Leu Ala Leu Leu Thr Leu Ser Gly Leu Leu Pro Ile Ala Arg
                  45                  50                  55

 gtg ctg acc gtg gga gcc gac cga gat cag cag ttg tgt gat cct ggt      364
 Val Leu Thr Val Gly Ala Asp Arg Asp Gln Gln Leu Cys Asp Pro Gly
              60                  65                  70

 gaa ttt ctt tgc cac gat cac gtg act tgt gtc tcc cag agc tgg ctg      412
 Glu Phe Leu Cys His Asp His Val Thr Cys Val Ser Gln Ser Trp Leu
          75                  80                  85

 tgt gat ggg gac cct gac tgc cct gat gat tca gac gag tct tta gat      460
 Cys Asp Gly Asp Pro Asp Cys Pro Asp Asp Ser Asp Glu Ser Leu Asp
      90                  95                 100

 acc tgt ccc gag gag gta gaa atc aag tgc ccc ttg aat cac att gct      508
 Thr Cys Pro Glu Glu Val Glu Ile Lys Cys Pro Leu Asn His Ile Ala
 105                 110                 115                 120

 tgc ctt ggc acc aac aaa tgt gtt cat tta tcc cag ctg tgc aat ggt      556
 Cys Leu Gly Thr Asn Lys Cys Val His Leu Ser Gln Leu Cys Asn Gly
                 125                 130                 135

 gtc ttg gac tgc cca gat ggg tat gac gaa gga gta cat tgt cag gaa      604
 Val Leu Asp Cys Pro Asp Gly Tyr Asp Glu Gly Val His Cys Gln Glu
             140                 145                 150

 ctg tta tcc aat tgc caa cag ctg aat tgt cag tat aaa tgt aca atg      652
 Leu Leu Ser Asn Cys Gln Gln Leu Asn Cys Gln Tyr Lys Cys Thr Met
         155                 160                 165

 gtc aga aat agt aca aga tgt tac tgt gag gat gga ttc gaa ata aca      700
 Val Arg Asn Ser Thr Arg Cys Tyr Cys Glu Asp Gly Phe Glu Ile Thr
     170                 175                 180

 gaa gat ggg att att aag aaa gca tga atttt actgccagac attttaatat      752
 Glu Asp Gly Ile Ile Lys Lys Ala 
 185                 190

 gcatttcaaa gctgcaagta ttatgtttga gcaaaaaaac accattagac aacacacaca    812

 cacacacaca cacacacaca aatttagact ttgaagttgg gctcttaaac aattatatgt    872

 ttcatataaa aaagtacttt tgagcaaaag acaaatgaga agtctttgtc acagcagatt    932

 gatatcacat cgtgttataa gcttgtttct ctgaacctct gcttaaacaa agaatttgaa    992

 ggaatgcttc gtcaaacaag tatttcagta agaagtatga aggaaaattt ttccttcata   1052

 atctttccat gatattagac tgttaacttt cttgtaattn tgtcttttta aaaatcaaca   1112

 tctaaattct acaatggtac aatattacct aa                                 1144




      <210> 29
      <211> 1785
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (425)..(1135)

      <400> 29
 gggggcagca tccggcggca gcggagcctg tggctccccc tgcgggctgc tcagcggcgt     60

 gcacagtcct gccggctggc ttgggtgggt ggtgggctgc gggtagggga ggggatggac    120

 cgagtcccgg cttgtcggga tgagggttcc ggaagatctg gccagtaaga ttctactccc    180

 tggctgtgca ccgggttccc tacccctgtc tacgtcggct ccgccacttc gcggcttgag    240

 actaaaagag catcccggca gggggccttc cagccccaaa gcagcctgtc cagagacccc    300

 caaattctga tcctgaagtt ggaggcctcc ggggatgttc ttttttaatc ttttagaagg    360

 gttagagggg ttgaggctgc ctgaccccag cctaatgggg taggtaggcc ttgggaagtg    420

 gagc atg ggg gca aag gat cca agc att gag cct tca tcc tct att ccc     469
      Met Gly Ala Lys Asp Pro Ser Ile Glu Pro Ser Ser Ser Ile Pro
        1               5                  10                  15

 cat cca gtg ggg tgc cga ggc tca ggc agc atg acg acg gag acc ttt      517
 His Pro Val Gly Cys Arg Gly Ser Gly Ser Met Thr Thr Glu Thr Phe
                  20                  25                  30

 gtg aag gat atc aag cct ggg ctc aag aat ctg aac ctt atc ttc att      565
 Val Lys Asp Ile Lys Pro Gly Leu Lys Asn Leu Asn Leu Ile Phe Ile
              35                  40                  45

 gtg ctg gag aca ggc cga gtg acc aag aca aag gac ggg cat gag gtt      613
 Val Leu Glu Thr Gly Arg Val Thr Lys Thr Lys Asp Gly His Glu Val
          50                  55                  60

 cgg acc tgc aaa gtg gcg gac aaa aca ggc agc atc aat atc tct gtc      661
 Arg Thr Cys Lys Val Ala Asp Lys Thr Gly Ser Ile Asn Ile Ser Val
      65                  70                  75

 tgg gac gat gtt ggc aat ctg atc cag cct ggg gac att atc cgg ctc      709
 Trp Asp Asp Val Gly Asn Leu Ile Gln Pro Gly Asp Ile Ile Arg Leu
  80                  85                  90                  95

 acc aaa ggg tac gct tca gtt ttc aaa ggt tgt ctg aca cta tat act      757
 Thr Lys Gly Tyr Ala Ser Val Phe Lys Gly Cys Leu Thr Leu Tyr Thr
                 100                 105                 110

 ggc cgt ggg ggt gat ctg cag aag att gga gaa ttc tgt atg gtt tat      805
 Gly Arg Gly Gly Asp Leu Gln Lys Ile Gly Glu Phe Cys Met Val Tyr
             115                 120                 125

 tct gag gtt cct aac ttc agt gag cca aac cca gag tac agc acc cag      853
 Ser Glu Val Pro Asn Phe Ser Glu Pro Asn Pro Glu Tyr Ser Thr Gln
         130                 135                 140

 cag gca ccc aac aag gcg gtg cag aac gac agc aac cct tca gct tcc      901
 Gln Ala Pro Asn Lys Ala Val Gln Asn Asp Ser Asn Pro Ser Ala Ser
     145                 150                 155

 cag cct acc act gga ccc tct gct gcc tct cca gcc tct gag aac cag      949
 Gln Pro Thr Thr Gly Pro Ser Ala Ala Ser Pro Ala Ser Glu Asn Gln
 160                 165                 170                 175

 aat ggg aat gga ctg agt gcc cca cca ggt ccc ggt ggt ggc cca cat      997
 Asn Gly Asn Gly Leu Ser Ala Pro Pro Gly Pro Gly Gly Gly Pro His
                 180                 185                 190

 ccc cct cat act ccc tcc cac cca ccc agc acc cga atc act cga agc     1045
 Pro Pro His Thr Pro Ser His Pro Pro Ser Thr Arg Ile Thr Arg Ser
             195                 200                 205

 cag ccc aac cac aca cct gca ggc ccg cct ggc cct tcc agc aac cct     1093
 Gln Pro Asn His Thr Pro Ala Gly Pro Pro Gly Pro Ser Ser Asn Pro
         210                 215                 220

 gtt agt aac ggc aaa gaa acc cgg agg agc agc aag aga tag catgaca     1142
 Val Ser Asn Gly Lys Glu Thr Arg Arg Ser Ser Lys Arg 
     225                 230                 235

 ttctttcttc ctgccaccaa ccacatccca agtgtcccct ggagagcaag atagccttcc   1202

 actgattggc tggtgtagca gtattttagc cactgaactt cagtggaggg tggtgagcag   1262

 tgtccttatc caccctaatc tcatactccc tcattgtcca gctgaactac ctgtcccctg   1322

 ggagtcagga ccctctgcct gctctctttc ctctttagaa atggcagtta ctggctgggc   1382

 gcagtggctc acgcttgtaa tcccagcact ttgggaagcc gaggtgggcg gatcacctga   1442

 ggtcgggagt tcaagaccag cctgaccaac atggagaaac cccgtgtcta ctaaaaatac   1502

 agaattagcc aggcatggtg gcgtatgcct gtaatcccag ctacttggga ggctgaggca   1562

 ggagaatctc ttgaaaccgg gaggcggagg ttgaggtgag ccgaaattgc accattgcac   1622

 tccagcctgg gcaataagag cgaaactcca tctcaaaaaa aaaaaaaaaa aaaaaagaaa   1682

 gaaatggcag ttaccatctg tttcttctgt gtgagacatg ggagtctaac tgaagtctct   1742

 ccttcctaat aaatgttacc actctaaaaa aaaaaaaaaa aaa                     1785




      <210> 30
      <211> 5560
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (311)..(5560)

      <400> 30
 tgtcgttgtt ctgagatata taagaggctt gagaaacttt tctgggaact cagctcacag     60

 gagtgtcccg cggaatgccc tgccgctttt cgccacagca tctctcttgc actccgcgtt    120

 caactggcta cctagagtct tttgctgatg ctacttgctt ttgccggact ggaggttctt    180

 tgaaatagca gaggtctcag accaagccgt cagctgaatc tttgctggcg ctccttaatc    240

 cctgtaaata tcattgcgtt tgcttcaccc cttccttctc tttatcacat cgttttaggg    300

 agccaggacc   atg gac tta gca cca gac agg gct act ggc cgc ccg tgg     349
              Met Asp Leu Ala Pro Asp Arg Ala Thr Gly Arg Pro Trp
                1               5                  10

 ctc ccg ttg cac act cta tca gta tct cag ctc ctt cga gtg ttt tgg      397
 Leu Pro Leu His Thr Leu Ser Val Ser Gln Leu Leu Arg Val Phe Trp
      15                  20                  25

 cta ctg tca ttg ctt ccg ggg cag gcc tgg gtc cac ggg gcc gag ccg      445
 Leu Leu Ser Leu Leu Pro Gly Gln Ala Trp Val His Gly Ala Glu Pro
  30                  35                  40                  45

 cgc cag gtg ttc caa gtg ctg gaa gag caa cct cca ggc act ctg gta      493
 Arg Gln Val Phe Gln Val Leu Glu Glu Gln Pro Pro Gly Thr Leu Val
                  50                  55                  60

 ggc acc atc cag acg cgc ccc ggc ttc acc tac agg ctc agc gaa agc      541
 Gly Thr Ile Gln Thr Arg Pro Gly Phe Thr Tyr Arg Leu Ser Glu Ser
              65                  70                  75

 cac gcc ctg ttt gcc ata aac agt agc acc gga gcc ctg tac acc acc      589
 His Ala Leu Phe Ala Ile Asn Ser Ser Thr Gly Ala Leu Tyr Thr Thr
          80                  85                  90

 tcc acc atc gac cgc gag agc ctg ccc agc gac gtg atc aac ctg gtg      637
 Ser Thr Ile Asp Arg Glu Ser Leu Pro Ser Asp Val Ile Asn Leu Val
      95                 100                 105

 gtc ctt tcc agc gcg ccc acc tac ccc acc gaa gtg cga gtg ctg gtg      685
 Val Leu Ser Ser Ala Pro Thr Tyr Pro Thr Glu Val Arg Val Leu Val
 110                 115                 120                 125

 cgg gac ctc aat gac aac gcc ccc gtt ttc ccg gac ccc tct atc gtg      733
 Arg Asp Leu Asn Asp Asn Ala Pro Val Phe Pro Asp Pro Ser Ile Val
                 130                 135                 140

 gtc act ttc aag gaa gac agt agc agc gga cgc caa gtc atc tta gac      781
 Val Thr Phe Lys Glu Asp Ser Ser Ser Gly Arg Gln Val Ile Leu Asp
             145                 150                 155

 acc gcc acc gac tcg gac atc ggc tca aac ggt gtg gac cac cgc tcc      829
 Thr Ala Thr Asp Ser Asp Ile Gly Ser Asn Gly Val Asp His Arg Ser
         160                 165                 170

 tac cgc atc atc cgc ggc aat gag gcg ggg cgc ttc cgt ctg gac atc      877
 Tyr Arg Ile Ile Arg Gly Asn Glu Ala Gly Arg Phe Arg Leu Asp Ile
     175                 180                 185

 acc ctg aac ccg agc ggc gag gga gcg ttc ctg cat ctg gtg tcc aag      925
 Thr Leu Asn Pro Ser Gly Glu Gly Ala Phe Leu His Leu Val Ser Lys
 190                 195                 200                 205

 ggc gga ctg gac cgt gag gtc act ccg cag tac cag ctc ctg gtt gag      973
 Gly Gly Leu Asp Arg Glu Val Thr Pro Gln Tyr Gln Leu Leu Val Glu
                 210                 215                 220

 gtg gag gac aag ggt gag cct aag cgg cgg ggc tac ctt cag gta aac     1021
 Val Glu Asp Lys Gly Glu Pro Lys Arg Arg Gly Tyr Leu Gln Val Asn
             225                 230                 235

 gtg act gtg caa gac att aat gac aac ccc ccg gtt ttt ggc agt tct     1069
 Val Thr Val Gln Asp Ile Asn Asp Asn Pro Pro Val Phe Gly Ser Ser
         240                 245                 250

 cac tac cag gcg ggg gtg cct gag gac gcg gtt gtg ggt tcc agc gtc     1117
 His Tyr Gln Ala Gly Val Pro Glu Asp Ala Val Val Gly Ser Ser Val
     255                 260                 265

 ctc cag gtg gcg gcg gcg gac gcg gac gag ggc acc aac gcg gac atc     1165
 Leu Gln Val Ala Ala Ala Asp Ala Asp Glu Gly Thr Asn Ala Asp Ile
 270                 275                 280                 285

 cgc tat cgc ctg cag gac gag ggg acc ccc ttc caa atg gac cct gag     1213
 Arg Tyr Arg Leu Gln Asp Glu Gly Thr Pro Phe Gln Met Asp Pro Glu
                 290                 295                 300

 acg gga ctt atc acg gtg cgg gag ccc ctg gac ttc gaa gct cgg cgc     1261
 Thr Gly Leu Ile Thr Val Arg Glu Pro Leu Asp Phe Glu Ala Arg Arg
             305                 310                 315

 caa tac tcg ctt acg gtg cag gcg atg gac aga ggc gtg cct tcc ctc     1309
 Gln Tyr Ser Leu Thr Val Gln Ala Met Asp Arg Gly Val Pro Ser Leu
         320                 325                 330

 act ggg cgc gcc gag gcg ctg att cag ctg ctg gac gtg aat gac aat     1357
 Thr Gly Arg Ala Glu Ala Leu Ile Gln Leu Leu Asp Val Asn Asp Asn
     335                 340                 345

 gac ccg gta gtg aag ttc cgc tac ttc ccg gcc acc tcg cgc tac gcc     1405
 Asp Pro Val Val Lys Phe Arg Tyr Phe Pro Ala Thr Ser Arg Tyr Ala
 350                 355                 360                 365

 tcg gta gat gag aat gct caa gtg ggc acc gtg gtg gct ctg ctc acc     1453
 Ser Val Asp Glu Asn Ala Gln Val Gly Thr Val Val Ala Leu Leu Thr
                 370                 375                 380

 gtg acg gac gca gat tct ccc gcg gcc aac ggg aac atc tcc gtg caa     1501
 Val Thr Asp Ala Asp Ser Pro Ala Ala Asn Gly Asn Ile Ser Val Gln
             385                 390                 395

 att ctc ggg ggc aat gag cag cgc cac ttt gaa gtg caa agc agc aaa     1549
 Ile Leu Gly Gly Asn Glu Gln Arg His Phe Glu Val Gln Ser Ser Lys
         400                 405                 410

 gtg ccg aac ctg agc cta atc aag gtg gcc agc gcc ttg gac cgc gag     1597
 Val Pro Asn Leu Ser Leu Ile Lys Val Ala Ser Ala Leu Asp Arg Glu
     415                 420                 425

 cgc atc cct tcc tac aac ctc aca gtt tcc gtc tct gat aac tac ggg     1645
 Arg Ile Pro Ser Tyr Asn Leu Thr Val Ser Val Ser Asp Asn Tyr Gly
 430                 435                 440                 445

 gcg ccc cct ggc gca gca gtc ctg gcg cgc tct tct gtg gca agc ctg     1693
 Ala Pro Pro Gly Ala Ala Val Leu Ala Arg Ser Ser Val Ala Ser Leu
                 450                 455                 460

 gtg att ttt gtt aat gac atc aat gac cat cct cct gtc ttt tca cag     1741
 Val Ile Phe Val Asn Asp Ile Asn Asp His Pro Pro Val Phe Ser Gln
             465                 470                 475

 caa gtg tac aga gtg aac ctg agc gag gag gcg cct ccg gga agc tat     1789
 Gln Val Tyr Arg Val Asn Leu Ser Glu Glu Ala Pro Pro Gly Ser Tyr
         480                 485                 490

 gtg agt ggg ata tct gcc act gat ggc gac tct ggt ctc aat gct aat     1837
 Val Ser Gly Ile Ser Ala Thr Asp Gly Asp Ser Gly Leu Asn Ala Asn
     495                 500                 505

 ctg cgt tac agc att gtc tct ggc aat gga ctg gga tgg ttc cat atc     1885
 Leu Arg Tyr Ser Ile Val Ser Gly Asn Gly Leu Gly Trp Phe His Ile
 510                 515                 520                 525

 agt gaa cat agc ggc ctc gtg acc act ggg tcc tct ggg ggc ctg gac     1933
 Ser Glu His Ser Gly Leu Val Thr Thr Gly Ser Ser Gly Gly Leu Asp
                 530                 535                 540

 cgt gaa ctt gct tcc cag att gtt ctg aat ata agt gcc cgg gac cag     1981
 Arg Glu Leu Ala Ser Gln Ile Val Leu Asn Ile Ser Ala Arg Asp Gln
             545                 550                 555

 gga gtt cac ccc aag gtg tcc tat gcc cag ctt gta gta act ctc cta     2029
 Gly Val His Pro Lys Val Ser Tyr Ala Gln Leu Val Val Thr Leu Leu
         560                 565                 570

 gat gtg aat gat gaa aag cca gta ttt agc cag cca gaa ggg tat gat     2077
 Asp Val Asn Asp Glu Lys Pro Val Phe Ser Gln Pro Glu Gly Tyr Asp
     575                 580                 585

 gtg tct gtg gtt gag aat gcc cca aca ggg aca gaa ctg ttg atg ctc     2125
 Val Ser Val Val Glu Asn Ala Pro Thr Gly Thr Glu Leu Leu Met Leu
 590                 595                 600                 605

 agg gca act gac ggg gac ctg ggt gac aac gga aca gtg cgc ttc tcc     2173
 Arg Ala Thr Asp Gly Asp Leu Gly Asp Asn Gly Thr Val Arg Phe Ser
                 610                 615                 620

 tta caa gag gca gag act gac cgg agg tcc ttc cgt ctg gat cct gtg     2221
 Leu Gln Glu Ala Glu Thr Asp Arg Arg Ser Phe Arg Leu Asp Pro Val
             625                 630                 635

 tct ggg agg ttg agt act att tcc tcc ttg gac aga gaa gag caa gcc     2269
 Ser Gly Arg Leu Ser Thr Ile Ser Ser Leu Asp Arg Glu Glu Gln Ala
         640                 645                 650

 ttc tac tcc ctg ttg gtt ctg gcc aca gat ctg ggc tcc cct ccc cag     2317
 Phe Tyr Ser Leu Leu Val Leu Ala Thr Asp Leu Gly Ser Pro Pro Gln
     655                 660                 665

 tca tca atg gct cgc ata aat gtg agt ctt ctg gat ata aat gat aac     2365
 Ser Ser Met Ala Arg Ile Asn Val Ser Leu Leu Asp Ile Asn Asp Asn
 670                 675                 680                 685

 agc cct gtc ttc tac ccg gtc caa tac ttt gct cac att aag gag aat     2413
 Ser Pro Val Phe Tyr Pro Val Gln Tyr Phe Ala His Ile Lys Glu Asn
                 690                 695                 700

 gag cct gga ggt agc tac atc acc act gtg tct gcc act gac cca gac     2461
 Glu Pro Gly Gly Ser Tyr Ile Thr Thr Val Ser Ala Thr Asp Pro Asp
             705                 710                 715

 ttg ggt acc aat ggt act gtc aaa tat agc ata tct gct ggg gac agg     2509
 Leu Gly Thr Asn Gly Thr Val Lys Tyr Ser Ile Ser Ala Gly Asp Arg
         720                 725                 730

 tct cgg ttt cag gtc aat gct cag agt ggg gtt att tct aca aga atg     2557
 Ser Arg Phe Gln Val Asn Ala Gln Ser Gly Val Ile Ser Thr Arg Met
     735                 740                 745

 gcc cta gac aga gaa gaa aaa aca gct tat cag ttg caa ata gta gct     2605
 Ala Leu Asp Arg Glu Glu Lys Thr Ala Tyr Gln Leu Gln Ile Val Ala
 750                 755                 760                 765

 act gat ggt ggc aat tta caa tct ccc aac cag gca ata gta acc atc     2653
 Thr Asp Gly Gly Asn Leu Gln Ser Pro Asn Gln Ala Ile Val Thr Ile
                 770                 775                 780

 act gta ttg gac act caa gac aac cca cct gta ttc agt cag gtt gcc     2701
 Thr Val Leu Asp Thr Gln Asp Asn Pro Pro Val Phe Ser Gln Val Ala
             785                 790                 795

 tac agc ttt gtg gtt ttt gag aac gtg gcg ctg gga tat cat gtg ggt     2749
 Tyr Ser Phe Val Val Phe Glu Asn Val Ala Leu Gly Tyr His Val Gly
         800                 805                 810

 agt gtg tct gca tcc acc atg gat ctc aat tcc aac atc agt tat ctc     2797
 Ser Val Ser Ala Ser Thr Met Asp Leu Asn Ser Asn Ile Ser Tyr Leu
     815                 820                 825

 att act act ggg gat cag aaa ggt atg ttt gct atc aac cag gtc act     2845
 Ile Thr Thr Gly Asp Gln Lys Gly Met Phe Ala Ile Asn Gln Val Thr
 830                 835                 840                 845

 ggg cag ctt acc aca gca aat gtg att gat aga gaa gag caa tcc ttt     2893
 Gly Gln Leu Thr Thr Ala Asn Val Ile Asp Arg Glu Glu Gln Ser Phe
                 850                 855                 860

 tat cag ctg aag gta gtg gcc agt ggg ggc aca gtg act gga gac act     2941
 Tyr Gln Leu Lys Val Val Ala Ser Gly Gly Thr Val Thr Gly Asp Thr
             865                 870                 875

 atg gtt aac ata aca gtt aag gat ttg aat gac aac tct ccc cat ttc     2989
 Met Val Asn Ile Thr Val Lys Asp Leu Asn Asp Asn Ser Pro His Phe
         880                 885                 890

 ctt cag gca ata gag agt gta aat gtg gtg gag aat tgg cag gca ggt     3037
 Leu Gln Ala Ile Glu Ser Val Asn Val Val Glu Asn Trp Gln Ala Gly
     895                 900                 905

 cac agc att ttc cag gcc aaa gct gtg gac cct gat gaa ggt gtc aat     3085
 His Ser Ile Phe Gln Ala Lys Ala Val Asp Pro Asp Glu Gly Val Asn
 910                 915                 920                 925

 ggc atg gta ctc tat agt ctg aag caa aac ccc aag aac ctg ttt gct     3133
 Gly Met Val Leu Tyr Ser Leu Lys Gln Asn Pro Lys Asn Leu Phe Ala
                 930                 935                 940

 atc aat gaa aag aat ggc act att agt ctg ctt ggg ccc ctg gat gtt     3181
 Ile Asn Glu Lys Asn Gly Thr Ile Ser Leu Leu Gly Pro Leu Asp Val
             945                 950                 955

 cat gct ggc tcc tac caa ata gag atc ttg gca tct gac atg ggt gtc     3229
 His Ala Gly Ser Tyr Gln Ile Glu Ile Leu Ala Ser Asp Met Gly Val
         960                 965                 970

 cca cag ctc tcc tct agt gtc atc cta aca gtt tat gtc cat gat gta     3277
 Pro Gln Leu Ser Ser Ser Val Ile Leu Thr Val Tyr Val His Asp Val
     975                 980                 985

 aat gac aat tca cca gtg ttt gac caa ctc tct tat gaa gtc acc ctt     3325
 Asn Asp Asn Ser Pro Val Phe Asp Gln Leu Ser Tyr Glu Val Thr Leu
 990                 995                1000                1005

 tct gag tca gaa cct gtg aat tct cga ttc ttt aaa gta caa gct tct     3373
 Ser Glu Ser Glu Pro Val Asn Ser Arg Phe Phe Lys Val Gln Ala Ser
                1010                1015                1020

 gat aag gat tca gga gca aat ggt gaa att gca tac acc att gct gaa     3421
 Asp Lys Asp Ser Gly Ala Asn Gly Glu Ile Ala Tyr Thr Ile Ala Glu
            1025                1030                1035

 gga aat aca ggg gat gct ttt ggc ata ttc cca gat ggt caa ttg tat     3469
 Gly Asn Thr Gly Asp Ala Phe Gly Ile Phe Pro Asp Gly Gln Leu Tyr
        1040                1045                1050

 ata aaa agt gaa ctg gac cgt gaa ctt caa gac aga tat gtt tta atg     3517
 Ile Lys Ser Glu Leu Asp Arg Glu Leu Gln Asp Arg Tyr Val Leu Met
    1055                1060                1065

 gtt gtt gct tct gac aga gca gtg gaa ccc ctt agt gct act gtg aat     3565
 Val Val Ala Ser Asp Arg Ala Val Glu Pro Leu Ser Ala Thr Val Asn
1070                1075                1080                1085

 gtt act gta att tta gaa gat gta aat gat aac aga cct ctt ttt aac     3613
 Val Thr Val Ile Leu Glu Asp Val Asn Asp Asn Arg Pro Leu Phe Asn
                1090                1095                1100

 agt acc aat tac aca ttt tac ttc gaa gaa gag cag agg gct ggg tcg     3661
 Ser Thr Asn Tyr Thr Phe Tyr Phe Glu Glu Glu Gln Arg Ala Gly Ser
            1105                1110                1115

 ttt gtg ggc aaa gta agt gct gta gat aaa gac ttt ggg cca aat gga     3709
 Phe Val Gly Lys Val Ser Ala Val Asp Lys Asp Phe Gly Pro Asn Gly
        1120                1125                1130

 gaa gta agg tat tct ttt gaa atg gtg cag cca gat ttt gag ttg cat     3757
 Glu Val Arg Tyr Ser Phe Glu Met Val Gln Pro Asp Phe Glu Leu His
    1135                1140                1145

 gcc atc agt ggg gaa att aca aat act cat cag ttt gac agg gag tct     3805
 Ala Ile Ser Gly Glu Ile Thr Asn Thr His Gln Phe Asp Arg Glu Ser
1150                1155                1160                1165

 ctt atg agg cgg aga ggg act gct gtg ttt agc ttt aca gtc ata gca     3853
 Leu Met Arg Arg Arg Gly Thr Ala Val Phe Ser Phe Thr Val Ile Ala
                1170                1175                1180

 aca gat cag ggg atc cct cag cct ctc aag gat cag gcc act gta cat     3901
 Thr Asp Gln Gly Ile Pro Gln Pro Leu Lys Asp Gln Ala Thr Val His
            1185                1190                1195

 gtt tac atg aag gat ata aat gat aat gct ccc aaa ttt tta aaa gac     3949
 Val Tyr Met Lys Asp Ile Asn Asp Asn Ala Pro Lys Phe Leu Lys Asp
        1200                1205                1210

 ttt tac caa gct aca ata tca gaa tca gca gcc aat ctg aca caa gtg     3997
 Phe Tyr Gln Ala Thr Ile Ser Glu Ser Ala Ala Asn Leu Thr Gln Val
    1215                1220                1225

 tta aga gta tct gcc tca gat gtt gat gaa ggt aat aat gga ctt att     4045
 Leu Arg Val Ser Ala Ser Asp Val Asp Glu Gly Asn Asn Gly Leu Ile
1230                1235                1240                1245

 cac tat tct ata ata aaa gga aat gaa gaa aga cag ttt gct ata gac     4093
 His Tyr Ser Ile Ile Lys Gly Asn Glu Glu Arg Gln Phe Ala Ile Asp
                1250                1255                1260

 agt acc tct ggt cag gta aca cta att ggc aaa tta gac tat gaa gca     4141
 Ser Thr Ser Gly Gln Val Thr Leu Ile Gly Lys Leu Asp Tyr Glu Ala
            1265                1270                1275

 aca cct gcc tat tcc ctt gta att caa gca gtg gat tca ggg aca atc     4189
 Thr Pro Ala Tyr Ser Leu Val Ile Gln Ala Val Asp Ser Gly Thr Ile
        1280                1285                1290

 ccc ctc aat tca acg tgt act tta aat att gat att tta gat gaa aat     4237
 Pro Leu Asn Ser Thr Cys Thr Leu Asn Ile Asp Ile Leu Asp Glu Asn
    1295                1300                1305

 gac aat acc cct tct ttc cct aaa tca aca ctc ttt gtt gat gtt ttg     4285
 Asp Asn Thr Pro Ser Phe Pro Lys Ser Thr Leu Phe Val Asp Val Leu
1310                1315                1320                1325

 gaa aac atg aga att ggt gaa ctc gtg tcc tct gtt act gca act gat     4333
 Glu Asn Met Arg Ile Gly Glu Leu Val Ser Ser Val Thr Ala Thr Asp
                1330                1335                1340

 tcc gat tca ggt gac aat gct gat tta tat tac agt att act ggg act     4381
 Ser Asp Ser Gly Asp Asn Ala Asp Leu Tyr Tyr Ser Ile Thr Gly Thr
            1345                1350                1355

 aac aac cac gga act ttt agc att agc cca aac act ggg agt att ttt     4429
 Asn Asn His Gly Thr Phe Ser Ile Ser Pro Asn Thr Gly Ser Ile Phe
        1360                1365                1370

 ctt gcc aaa aaa ctg gac ttt gaa aca cag tct ttg tat aaa tta aat     4477
 Leu Ala Lys Lys Leu Asp Phe Glu Thr Gln Ser Leu Tyr Lys Leu Asn
    1375                1380                1385

 ata aca gca aaa gac caa gga aga cct cct cgt tca tct aca atg tca     4525
 Ile Thr Ala Lys Asp Gln Gly Arg Pro Pro Arg Ser Ser Thr Met Ser
1390                1395                1400                1405

 gtg gtt att cac gtg agg gac ttt aat gac aat cct cct agc ttt cct     4573
 Val Val Ile His Val Arg Asp Phe Asn Asp Asn Pro Pro Ser Phe Pro
                1410                1415                1420

 cct gga gat att ttc aag tct att gtt gag aac att ccc att ggt aca     4621
 Pro Gly Asp Ile Phe Lys Ser Ile Val Glu Asn Ile Pro Ile Gly Thr
            1425                1430                1435

 tct gtc att tca gtg act gca cat gac cct gat gca gac att aat ggt     4669
 Ser Val Ile Ser Val Thr Ala His Asp Pro Asp Ala Asp Ile Asn Gly
        1440                1445                1450

 caa cta tcc tac aca atc att caa cag atg cca aga ggc aac cac ttt     4717
 Gln Leu Ser Tyr Thr Ile Ile Gln Gln Met Pro Arg Gly Asn His Phe
    1455                1460                1465

 acc ata gat gaa gtc aaa ggg act ata tat act aat gct gaa ata gat     4765
 Thr Ile Asp Glu Val Lys Gly Thr Ile Tyr Thr Asn Ala Glu Ile Asp
1470                1475                1480                1485

 cgg gaa ttt gct aat ctc ttt gag ttg act gta aaa gcc aat gat caa     4813
 Arg Glu Phe Ala Asn Leu Phe Glu Leu Thr Val Lys Ala Asn Asp Gln
                1490                1495                1500

 gct gtg cca ata gaa act aga cgg tat gct ttg aag aac gtg acc att     4861
 Ala Val Pro Ile Glu Thr Arg Arg Tyr Ala Leu Lys Asn Val Thr Ile
            1505                1510                1515

 ttg gtt aca gac ctc aat gac aat gtc cca atg ttt ata tca caa aac     4909
 Leu Val Thr Asp Leu Asn Asp Asn Val Pro Met Phe Ile Ser Gln Asn
        1520                1525                1530

 gcc ctt gct gca gac cca tca gct gtg att ggt tcc gtt ctg aca aca     4957
 Ala Leu Ala Ala Asp Pro Ser Ala Val Ile Gly Ser Val Leu Thr Thr
    1535                1540                1545

 att atg gct gct gac cca gat gaa ggt gct aat gga gaa ata gag tat     5005
 Ile Met Ala Ala Asp Pro Asp Glu Gly Ala Asn Gly Glu Ile Glu Tyr
1550                1555                1560                1565

 gag atc atc aat ggg gac aca gac acc ttc att gtt gat cgt tat agt     5053
 Glu Ile Ile Asn Gly Asp Thr Asp Thr Phe Ile Val Asp Arg Tyr Ser
                1570                1575                1580

 gga gac ctg aga gtg gct tca gcg ttg gtg cct tca cag ttg atc tac     5101
 Gly Asp Leu Arg Val Ala Ser Ala Leu Val Pro Ser Gln Leu Ile Tyr
            1585                1590                1595

 aat ctc ata gtt tca gca aca gac ctt ggg cct gaa agg agg aaa tcg     5149
 Asn Leu Ile Val Ser Ala Thr Asp Leu Gly Pro Glu Arg Arg Lys Ser
        1600                1605                1610

 acc act gaa ttg acc atc att ctt cag ggc ctt gat gga cct gtt ttt     5197
 Thr Thr Glu Leu Thr Ile Ile Leu Gln Gly Leu Asp Gly Pro Val Phe
    1615                1620                1625

 act caa ccc aaa tat ata act att ttg aag gaa gga gaa ccc att ggc     5245
 Thr Gln Pro Lys Tyr Ile Thr Ile Leu Lys Glu Gly Glu Pro Ile Gly
1630                1635                1640                1645

 aca aac gtg ata tca ata gaa gca gct agc ccc aga gga tct gag gcc     5293
 Thr Asn Val Ile Ser Ile Glu Ala Ala Ser Pro Arg Gly Ser Glu Ala
                1650                1655                1660

 cca gtg gag tat tat att gtt tca gtt cgt tgt gaa gaa aaa act gtt     5341
 Pro Val Glu Tyr Tyr Ile Val Ser Val Arg Cys Glu Glu Lys Thr Val
            1665                1670                1675

 gga cgc ctc ttt act att gga cga cat act ggt ata att cag acc gca     5389
 Gly Arg Leu Phe Thr Ile Gly Arg His Thr Gly Ile Ile Gln Thr Ala
        1680                1685                1690

 gcc att ctg gac cgg gag caa gga gca tgt ctt tac ctg gtg gat gtt     5437
 Ala Ile Leu Asp Arg Glu Gln Gly Ala Cys Leu Tyr Leu Val Asp Val
    1695                1700                1705

 tat gcc ata gaa aaa tca act gct ttt ccc aga aca cag aga gca gag     5485
 Tyr Ala Ile Glu Lys Ser Thr Ala Phe Pro Arg Thr Gln Arg Ala Glu
1710                1715                1720                1725

 gcc cct caa aga cat tct agt gtc agt cag cca aaa aca caa aca tca     5533
 Ala Pro Gln Arg His Ser Ser Val Ser Gln Pro Lys Thr Gln Thr Ser
                1730                1735                1740

 aat gtg gtt tgt gat act tgg cag tga                                 5560
 Asn Val Val Cys Asp Thr Trp Gln 
            1745





      <210> 31
      <211> 5743
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (311)..(5500)

      <400> 31
 tgtcgttgtt ctgagatata taagaggctt gagaaacttt tctgggaact cagctcacag     60

 gagtgtcccg cggaatgccc tgccgctttt cgccacagca tctctcttgc actccgcgtt    120

 caactggcta cctagagtct tttgctgatg ctacttgctt ttgccggact ggaggttctt    180

 tgaaatagca gaggtctcag accaagccgt cagctgaatc tttgctggcg ctccttaatc    240

 cctgtaaata tcattgcgtt tgcttcaccc cttccttctc tttatcacat cgttttaggg    300

 agccaggacc   atg gac tta gca cca gac agg gct act ggc cgc ccg tgg     349
              Met Asp Leu Ala Pro Asp Arg Ala Thr Gly Arg Pro Trp
                1               5                  10

 ctc ccg ttg cac act cta tca gta tct cag ctc ctt cga gtg ttt tgg      397
 Leu Pro Leu His Thr Leu Ser Val Ser Gln Leu Leu Arg Val Phe Trp
      15                  20                  25

 cta ctg tca ttg ctt ccg ggg cag gcc tgg gtc cac ggg gcc gag ccg      445
 Leu Leu Ser Leu Leu Pro Gly Gln Ala Trp Val His Gly Ala Glu Pro
  30                  35                  40                  45

 cgc cag gtg ttc caa gtg ctg gaa gag caa cct cca ggc act ctg gta      493
 Arg Gln Val Phe Gln Val Leu Glu Glu Gln Pro Pro Gly Thr Leu Val
                  50                  55                  60

 ggc acc atc cag acg cgc ccc ggc ttc acc tac agg ctc agc gaa agc      541
 Gly Thr Ile Gln Thr Arg Pro Gly Phe Thr Tyr Arg Leu Ser Glu Ser
              65                  70                  75

 cac gcc ctg ttt gcc ata aac agt agc acc gga gcc ctg tac acc acc      589
 His Ala Leu Phe Ala Ile Asn Ser Ser Thr Gly Ala Leu Tyr Thr Thr
          80                  85                  90

 tcc acc atc gac cgc gag agc ctg ccc agc gac gtg atc aac ctg gtg      637
 Ser Thr Ile Asp Arg Glu Ser Leu Pro Ser Asp Val Ile Asn Leu Val
      95                 100                 105

 gtc ctt tcc agc gcg ccc acc tac ccc acc gaa gtg cga gtg ctg gtg      685
 Val Leu Ser Ser Ala Pro Thr Tyr Pro Thr Glu Val Arg Val Leu Val
 110                 115                 120                 125

 cgg gac ctc aat gac aac gcc ccc gtt ttc ccg gac ccc tct atc gtg      733
 Arg Asp Leu Asn Asp Asn Ala Pro Val Phe Pro Asp Pro Ser Ile Val
                 130                 135                 140

 gtc act ttc aag gaa gac agt agc agc gga cgc caa gtc atc tta gac      781
 Val Thr Phe Lys Glu Asp Ser Ser Ser Gly Arg Gln Val Ile Leu Asp
             145                 150                 155

 acc gcc acc gac tcg gac atc ggc tca aac ggt gtg gac cac cgc tcc      829
 Thr Ala Thr Asp Ser Asp Ile Gly Ser Asn Gly Val Asp His Arg Ser
         160                 165                 170

 tac cgc atc atc cgc ggc aat gag gcg ggg cgc ttc cgt ctg gac atc      877
 Tyr Arg Ile Ile Arg Gly Asn Glu Ala Gly Arg Phe Arg Leu Asp Ile
     175                 180                 185

 acc ctg aac ccg agc ggc gag gga gcg ttc ctg cat ctg gtg tcc aag      925
 Thr Leu Asn Pro Ser Gly Glu Gly Ala Phe Leu His Leu Val Ser Lys
 190                 195                 200                 205

 ggc gga ctg gac cgt gag gtc act ccg cag tac cag ctc ctg gtt gag      973
 Gly Gly Leu Asp Arg Glu Val Thr Pro Gln Tyr Gln Leu Leu Val Glu
                 210                 215                 220

 gtg gag gac aag ggt gag cct aag cgg cgg ggc tac ctt cag gta aac     1021
 Val Glu Asp Lys Gly Glu Pro Lys Arg Arg Gly Tyr Leu Gln Val Asn
             225                 230                 235

 gtg act gtg caa gac att aat gac aac ccc ccg gtt ttt ggc agt tct     1069
 Val Thr Val Gln Asp Ile Asn Asp Asn Pro Pro Val Phe Gly Ser Ser
         240                 245                 250

 cac tac cag gcg ggg gtg cct gag gac gcg gtt gtg ggt tcc agc gtc     1117
 His Tyr Gln Ala Gly Val Pro Glu Asp Ala Val Val Gly Ser Ser Val
     255                 260                 265

 ctc cag gtg gcg gcg gcg gac gcg gac gag ggc acc aac gcg gac atc     1165
 Leu Gln Val Ala Ala Ala Asp Ala Asp Glu Gly Thr Asn Ala Asp Ile
 270                 275                 280                 285

 cgc tat cgc ctg cag gac gag ggg acc ccc ttc caa atg gac cct gag     1213
 Arg Tyr Arg Leu Gln Asp Glu Gly Thr Pro Phe Gln Met Asp Pro Glu
                 290                 295                 300

 acg gga ctt atc acg gtg cgg gag ccc ctg gac ttc gaa gct cgg cgc     1261
 Thr Gly Leu Ile Thr Val Arg Glu Pro Leu Asp Phe Glu Ala Arg Arg
             305                 310                 315

 caa tac tcg ctt acg gtg cag gcg atg gac aga ggc gtg cct tcc ctc     1309
 Gln Tyr Ser Leu Thr Val Gln Ala Met Asp Arg Gly Val Pro Ser Leu
         320                 325                 330

 act ggg cgc gcc gag gcg ctg att cag ctg ctg gac gtg aat gac aat     1357
 Thr Gly Arg Ala Glu Ala Leu Ile Gln Leu Leu Asp Val Asn Asp Asn
     335                 340                 345

 gac ccg gta gtg aag ttc cgc tac ttc ccg gcc acc tcg cgc tac gcc     1405
 Asp Pro Val Val Lys Phe Arg Tyr Phe Pro Ala Thr Ser Arg Tyr Ala
 350                 355                 360                 365

 tcg gta gat gag aat gct caa gtg ggc acc gtg gtg gct ctg ctc acc     1453
 Ser Val Asp Glu Asn Ala Gln Val Gly Thr Val Val Ala Leu Leu Thr
                 370                 375                 380

 gtg acg gac gca gat tct ccc gcg gcc aac ggg aac atc tcc gtg caa     1501
 Val Thr Asp Ala Asp Ser Pro Ala Ala Asn Gly Asn Ile Ser Val Gln
             385                 390                 395

 att ctc ggg ggc aat gag cag cgc cac ttt gaa gtg caa agc agc aaa     1549
 Ile Leu Gly Gly Asn Glu Gln Arg His Phe Glu Val Gln Ser Ser Lys
         400                 405                 410

 gtg ccg aac ctg agc cta atc aag gtg gcc agc gcc ttg gac cgc gag     1597
 Val Pro Asn Leu Ser Leu Ile Lys Val Ala Ser Ala Leu Asp Arg Glu
     415                 420                 425

 cgc atc cct tcc tac aac ctc aca gtt tcc gtc tct gat aac tac ggg     1645
 Arg Ile Pro Ser Tyr Asn Leu Thr Val Ser Val Ser Asp Asn Tyr Gly
 430                 435                 440                 445

 gcg ccc cct ggc gca gca gtc cag gcg cgc tct tct gtg gca agc ctg     1693
 Ala Pro Pro Gly Ala Ala Val Gln Ala Arg Ser Ser Val Ala Ser Leu
                 450                 455                 460

 gtg att ttt gtt aat gac atc aat gac cat cct cct gtc ttt tca cag     1741
 Val Ile Phe Val Asn Asp Ile Asn Asp His Pro Pro Val Phe Ser Gln
             465                 470                 475

 caa gtg tac aga gtg aac ctg agc gag gag gcg cct ccg gga agc tat     1789
 Gln Val Tyr Arg Val Asn Leu Ser Glu Glu Ala Pro Pro Gly Ser Tyr
         480                 485                 490

 gtg agt ggg ata tct gcc act gat ggc gac tct ggt ctc aat gct aat     1837
 Val Ser Gly Ile Ser Ala Thr Asp Gly Asp Ser Gly Leu Asn Ala Asn
     495                 500                 505

 ctg cgt tac agc att gtc tct ggc aat gga ctg gga tgg ttc cat atc     1885
 Leu Arg Tyr Ser Ile Val Ser Gly Asn Gly Leu Gly Trp Phe His Ile
 510                 515                 520                 525

 agt gaa cat agc ggc ctc gtg acc act ggg tcc tct ggg ggc ctg gac     1933
 Ser Glu His Ser Gly Leu Val Thr Thr Gly Ser Ser Gly Gly Leu Asp
                 530                 535                 540

 cgt gaa ctt gct tcc cag att gtt ctg aat ata agt gcc cgg gac cag     1981
 Arg Glu Leu Ala Ser Gln Ile Val Leu Asn Ile Ser Ala Arg Asp Gln
             545                 550                 555

 gga gtt cac ccc aag gtg tcc tat gcc cag ctt gta gta act ctc cta     2029
 Gly Val His Pro Lys Val Ser Tyr Ala Gln Leu Val Val Thr Leu Leu
         560                 565                 570

 gat gtg aat gat gaa aag cca gta ttt agc cag cca gaa ggg tat gat     2077
 Asp Val Asn Asp Glu Lys Pro Val Phe Ser Gln Pro Glu Gly Tyr Asp
     575                 580                 585

 gtg tct gtg gtt gag aat gcc cca aca ggg aca gaa ctg ttg atg ctc     2125
 Val Ser Val Val Glu Asn Ala Pro Thr Gly Thr Glu Leu Leu Met Leu
 590                 595                 600                 605

 agg gca act gac ggg gac ctg ggt gac aac gga aca gtg cgc ttc tcc     2173
 Arg Ala Thr Asp Gly Asp Leu Gly Asp Asn Gly Thr Val Arg Phe Ser
                 610                 615                 620

 tta caa gag gca gag act gac cgg agg tcc ttc cgt ctg gat cct gtg     2221
 Leu Gln Glu Ala Glu Thr Asp Arg Arg Ser Phe Arg Leu Asp Pro Val
             625                 630                 635

 tct ggg agg ttg agt act att tcc tcc ttg gac aga gaa gag caa gcc     2269
 Ser Gly Arg Leu Ser Thr Ile Ser Ser Leu Asp Arg Glu Glu Gln Ala
         640                 645                 650

 ttc tac tcc ctg ttg gtt ctg gcc aca gat ctg ggc tcc cct ccc cag     2317
 Phe Tyr Ser Leu Leu Val Leu Ala Thr Asp Leu Gly Ser Pro Pro Gln
     655                 660                 665

 tca tca atg gct cgc ata aat gtg agt ctt ctg gat ata aat gat aac     2365
 Ser Ser Met Ala Arg Ile Asn Val Ser Leu Leu Asp Ile Asn Asp Asn
 670                 675                 680                 685

 agc cct gtc ttc tac ccg gtc caa tac ttt gct cac att aag gag aat     2413
 Ser Pro Val Phe Tyr Pro Val Gln Tyr Phe Ala His Ile Lys Glu Asn
                 690                 695                 700

 gag cct gga ggt agc tac atc acc act gtg tct gcc act gac cca gac     2461
 Glu Pro Gly Gly Ser Tyr Ile Thr Thr Val Ser Ala Thr Asp Pro Asp
             705                 710                 715

 ttg ggt acc aat ggt act gtc aaa tat agc ata tct gct ggg gac agg     2509
 Leu Gly Thr Asn Gly Thr Val Lys Tyr Ser Ile Ser Ala Gly Asp Arg
         720                 725                 730

 tct cgg ttt cag gtc aat gct cag agt ggg gtt att tct aca aga atg     2557
 Ser Arg Phe Gln Val Asn Ala Gln Ser Gly Val Ile Ser Thr Arg Met
     735                 740                 745

 gcc cta gac aga gaa gaa aaa aca gct tat cag ttg caa ata gta gct     2605
 Ala Leu Asp Arg Glu Glu Lys Thr Ala Tyr Gln Leu Gln Ile Val Ala
 750                 755                 760                 765

 act gat ggt ggc aat tta caa tct ccc aac cag gca ata gta acc atc     2653
 Thr Asp Gly Gly Asn Leu Gln Ser Pro Asn Gln Ala Ile Val Thr Ile
                 770                 775                 780

 act gta ttg gac act caa gac aac cca cct gta ttc agt cag gtt gcc     2701
 Thr Val Leu Asp Thr Gln Asp Asn Pro Pro Val Phe Ser Gln Val Ala
             785                 790                 795

 tac agc ttt gtg gtt ttt gag aac gtg gcg ctg gga tat cat gtg ggt     2749
 Tyr Ser Phe Val Val Phe Glu Asn Val Ala Leu Gly Tyr His Val Gly
         800                 805                 810

 agt gtg tct gca tcc acc atg gat ctc aat tcc aac atc agt tat ctc     2797
 Ser Val Ser Ala Ser Thr Met Asp Leu Asn Ser Asn Ile Ser Tyr Leu
     815                 820                 825

 att act act ggg gat cag aaa ggt atg ttt gct atc aac cag gtc act     2845
 Ile Thr Thr Gly Asp Gln Lys Gly Met Phe Ala Ile Asn Gln Val Thr
 830                 835                 840                 845

 ggg cag ctt acc aca gca aat gtg att gat aga gaa gag caa tcc ttt     2893
 Gly Gln Leu Thr Thr Ala Asn Val Ile Asp Arg Glu Glu Gln Ser Phe
                 850                 855                 860

 tat cag ctg aag gta gtg gcc agt ggg ggc aca gtg act gga gac act     2941
 Tyr Gln Leu Lys Val Val Ala Ser Gly Gly Thr Val Thr Gly Asp Thr
             865                 870                 875

 atg gtt aac ata aca gtt aag gat ttg aat gac aac tct ccc cat ttc     2989
 Met Val Asn Ile Thr Val Lys Asp Leu Asn Asp Asn Ser Pro His Phe
         880                 885                 890

 ctt cag gca ata gag agt gta aat gtg gtg gag aat tgg cag gca ggt     3037
 Leu Gln Ala Ile Glu Ser Val Asn Val Val Glu Asn Trp Gln Ala Gly
     895                 900                 905

 cac agc att ttc cag gcc aaa gct gtg gac cct gat gaa ggt gtc aat     3085
 His Ser Ile Phe Gln Ala Lys Ala Val Asp Pro Asp Glu Gly Val Asn
 910                 915                 920                 925

 ggc atg gta ctc tat agt ctg aag caa aac ccc aag aac ctg ttt gct     3133
 Gly Met Val Leu Tyr Ser Leu Lys Gln Asn Pro Lys Asn Leu Phe Ala
                 930                 935                 940

 atc aat gaa aag aat ggc act att agt ctg ctt ggg ccc ctg gat gtt     3181
 Ile Asn Glu Lys Asn Gly Thr Ile Ser Leu Leu Gly Pro Leu Asp Val
             945                 950                 955

 cat gct ggc tcc tac caa ata gag atc ttg gca tct gac atg ggt gtc     3229
 His Ala Gly Ser Tyr Gln Ile Glu Ile Leu Ala Ser Asp Met Gly Val
         960                 965                 970

 cca cag ctc tcc tct agt gtc atc cta aca gtt tat gtc cat gat gta     3277
 Pro Gln Leu Ser Ser Ser Val Ile Leu Thr Val Tyr Val His Asp Val
     975                 980                 985

 aat gac aat tca cca gtg ttt gac caa ctc tct tat gaa gtc acc ctt     3325
 Asn Asp Asn Ser Pro Val Phe Asp Gln Leu Ser Tyr Glu Val Thr Leu
 990                 995                1000                1005

 tct gag tca gaa cct gtg aat tct cga ttc ttt aaa gta caa gct tct     3373
 Ser Glu Ser Glu Pro Val Asn Ser Arg Phe Phe Lys Val Gln Ala Ser
                1010                1015                1020

 gat aag gat tca gga gca aat ggt gaa att gca tac acc att gct gaa     3421
 Asp Lys Asp Ser Gly Ala Asn Gly Glu Ile Ala Tyr Thr Ile Ala Glu
            1025                1030                1035

 gga aat aca ggg gat gct ttt ggc ata ttc cca gat ggt caa ttg tat     3469
 Gly Asn Thr Gly Asp Ala Phe Gly Ile Phe Pro Asp Gly Gln Leu Tyr
        1040                1045                1050

 ata aaa agt gaa ctg gac cgt gaa ctt caa gac aga tat gtt tta atg     3517
 Ile Lys Ser Glu Leu Asp Arg Glu Leu Gln Asp Arg Tyr Val Leu Met
    1055                1060                1065

 gtt gtt gct tct gac aga gca gtg gaa ccc ctt agt gct act gtg aat     3565
 Val Val Ala Ser Asp Arg Ala Val Glu Pro Leu Ser Ala Thr Val Asn
1070                1075                1080                1085

 gtt act gta att tta gaa gat gta aat gat aac aga cct ctt ttt aac     3613
 Val Thr Val Ile Leu Glu Asp Val Asn Asp Asn Arg Pro Leu Phe Asn
                1090                1095                1100

 agt acc aat tac aca ttt tac ttc gaa gaa gag cag agg gct ggg tcg     3661
 Ser Thr Asn Tyr Thr Phe Tyr Phe Glu Glu Glu Gln Arg Ala Gly Ser
            1105                1110                1115

 ttt gtg ggc aaa gta agt gct gta gat aaa gac ttt ggg cca aat gga     3709
 Phe Val Gly Lys Val Ser Ala Val Asp Lys Asp Phe Gly Pro Asn Gly
        1120                1125                1130

 gaa gta agg tat tct ttt gaa atg gtg cag cca gat ttt gag ttg cat     3757
 Glu Val Arg Tyr Ser Phe Glu Met Val Gln Pro Asp Phe Glu Leu His
    1135                1140                1145

 gcc atc agt ggg gaa att aca aat act cat cag ttt gac agg gag tct     3805
 Ala Ile Ser Gly Glu Ile Thr Asn Thr His Gln Phe Asp Arg Glu Ser
1150                1155                1160                1165

 ctt atg agg cgg aga ggg act gct gtg ttt agc ttt aca gtc ata gca     3853
 Leu Met Arg Arg Arg Gly Thr Ala Val Phe Ser Phe Thr Val Ile Ala
                1170                1175                1180

 aca gat cag ggg atc cct cag cct ctc aag gat cag gcc act gta cat     3901
 Thr Asp Gln Gly Ile Pro Gln Pro Leu Lys Asp Gln Ala Thr Val His
            1185                1190                1195

 gtt tac atg aag gat ata aat gat aat gct ccc aaa ttt tta aaa gac     3949
 Val Tyr Met Lys Asp Ile Asn Asp Asn Ala Pro Lys Phe Leu Lys Asp
        1200                1205                1210

 ttt tac caa gct aca ata tca gaa tca gca gcc aat ctg aca caa gtg     3997
 Phe Tyr Gln Ala Thr Ile Ser Glu Ser Ala Ala Asn Leu Thr Gln Val
    1215                1220                1225

 tta aga gta tct gcc tca gat gtt gat gaa ggt aat aat gga ctt att     4045
 Leu Arg Val Ser Ala Ser Asp Val Asp Glu Gly Asn Asn Gly Leu Ile
1230                1235                1240                1245

 cac tat tct ata ata aaa gga aat gaa gaa aga cag ttt gct ata gac     4093
 His Tyr Ser Ile Ile Lys Gly Asn Glu Glu Arg Gln Phe Ala Ile Asp
                1250                1255                1260

 agt acc tct ggt cag gta aca cta att ggc aaa tta gac tat gaa gca     4141
 Ser Thr Ser Gly Gln Val Thr Leu Ile Gly Lys Leu Asp Tyr Glu Ala
            1265                1270                1275

 aca cct gcc tat tcc ctt gta att caa gca gtg gat tca ggg aca atc     4189
 Thr Pro Ala Tyr Ser Leu Val Ile Gln Ala Val Asp Ser Gly Thr Ile
        1280                1285                1290

 ccc ctc aat tca acg tgt act tta aat att gat att tta gat gaa aat     4237
 Pro Leu Asn Ser Thr Cys Thr Leu Asn Ile Asp Ile Leu Asp Glu Asn
    1295                1300                1305

 gac aat acc cct tct ttc cct aaa tca aca ctc ttt gtt gat gtt ttg     4285
 Asp Asn Thr Pro Ser Phe Pro Lys Ser Thr Leu Phe Val Asp Val Leu
1310                1315                1320                1325

 gaa aac atg aga att ggt gaa ctc gtg tcc tct gtt act gca act gat     4333
 Glu Asn Met Arg Ile Gly Glu Leu Val Ser Ser Val Thr Ala Thr Asp
                1330                1335                1340

 tcc gat tca ggt gac aat gct gat tta tat tac agt att act ggg act     4381
 Ser Asp Ser Gly Asp Asn Ala Asp Leu Tyr Tyr Ser Ile Thr Gly Thr
            1345                1350                1355

 aac aac cac gga act ttt agc att agc cca aac act ggg agt att ttt     4429
 Asn Asn His Gly Thr Phe Ser Ile Ser Pro Asn Thr Gly Ser Ile Phe
        1360                1365                1370

 ctt gcc aaa aaa ctg gac ttt gaa aca cag tct ttg tat aaa tta aat     4477
 Leu Ala Lys Lys Leu Asp Phe Glu Thr Gln Ser Leu Tyr Lys Leu Asn
    1375                1380                1385

 ata aca gca aaa gac caa gga aga cct cct cgt tca tct aca atg tca     4525
 Ile Thr Ala Lys Asp Gln Gly Arg Pro Pro Arg Ser Ser Thr Met Ser
1390                1395                1400                1405

 gtg gtt att cac gtg agg gac ttt aat gac aat cct cct agc ttt cct     4573
 Val Val Ile His Val Arg Asp Phe Asn Asp Asn Pro Pro Ser Phe Pro
                1410                1415                1420

 cct gga gat att ttc aag tct att gtt gag aac att ccc att ggt aca     4621
 Pro Gly Asp Ile Phe Lys Ser Ile Val Glu Asn Ile Pro Ile Gly Thr
            1425                1430                1435

 tct gtc att tca gtg act gca cat gac cct gat gca gac att aat ggt     4669
 Ser Val Ile Ser Val Thr Ala His Asp Pro Asp Ala Asp Ile Asn Gly
        1440                1445                1450

 caa cta tcc tac aca atc att caa cag atg cca aga ggc aac cac ttt     4717
 Gln Leu Ser Tyr Thr Ile Ile Gln Gln Met Pro Arg Gly Asn His Phe
    1455                1460                1465

 acc ata gat gaa gtc aaa ggg act ata tat act aat gct gaa ata gat     4765
 Thr Ile Asp Glu Val Lys Gly Thr Ile Tyr Thr Asn Ala Glu Ile Asp
1470                1475                1480                1485

 cgg gaa ttt gct aat ctc ttt gag ttg act gta aaa gcc aat gat caa     4813
 Arg Glu Phe Ala Asn Leu Phe Glu Leu Thr Val Lys Ala Asn Asp Gln
                1490                1495                1500

 gct gtg cca ata gaa act aga cgg tat gct ttg aag aac gtg acc att     4861
 Ala Val Pro Ile Glu Thr Arg Arg Tyr Ala Leu Lys Asn Val Thr Ile
            1505                1510                1515

 ttg gtt aca gac ctc aat gac aat gtc cca atg ttt ata tca caa aac     4909
 Leu Val Thr Asp Leu Asn Asp Asn Val Pro Met Phe Ile Ser Gln Asn
        1520                1525                1530

 gcc ctt gct gca gac cca tca gct gtg att ggt tcc gtt ctg aca aca     4957
 Ala Leu Ala Ala Asp Pro Ser Ala Val Ile Gly Ser Val Leu Thr Thr
    1535                1540                1545

 att atg gct gct gac cca gat gaa ggt gct aat gga gaa ata gag tat     5005
 Ile Met Ala Ala Asp Pro Asp Glu Gly Ala Asn Gly Glu Ile Glu Tyr
1550                1555                1560                1565

 gag atc atc aat ggg gac aca gac acc ttc att gtt gat cgt tat agt     5053
 Glu Ile Ile Asn Gly Asp Thr Asp Thr Phe Ile Val Asp Arg Tyr Ser
                1570                1575                1580

 gga gac ctg aga gtg gct tca gcg ttg gtg cct tca cag ttg atc tac     5101
 Gly Asp Leu Arg Val Ala Ser Ala Leu Val Pro Ser Gln Leu Ile Tyr
            1585                1590                1595

 aat ctc ata gtt tca gca aca gac ctt ggg cct gaa agg agg aaa tcg     5149
 Asn Leu Ile Val Ser Ala Thr Asp Leu Gly Pro Glu Arg Arg Lys Ser
        1600                1605                1610

 acc act gaa ttg acc atc att ctt cag ggc ctt gat gga cct gtt ttt     5197
 Thr Thr Glu Leu Thr Ile Ile Leu Gln Gly Leu Asp Gly Pro Val Phe
    1615                1620                1625

 act caa ccc aaa tat ata act att ttg aag gaa gga gaa ccc att ggc     5245
 Thr Gln Pro Lys Tyr Ile Thr Ile Leu Lys Glu Gly Glu Pro Ile Gly
1630                1635                1640                1645

 aca aac gtg ata tca ata gaa gca gct agc ccc aga gga tct gag gcc     5293
 Thr Asn Val Ile Ser Ile Glu Ala Ala Ser Pro Arg Gly Ser Glu Ala
                1650                1655                1660

 cca gtg gag tat tat att gtt tca gtt cgt tgt gaa gaa aaa act gtt     5341
 Pro Val Glu Tyr Tyr Ile Val Ser Val Arg Cys Glu Glu Lys Thr Val
            1665                1670                1675

 gga cgc ctc ttt act att gga cga cat act ggt ata att cag acc gca     5389
 Gly Arg Leu Phe Thr Ile Gly Arg His Thr Gly Ile Ile Gln Thr Ala
        1680                1685                1690

 gcc att ctg gac cgg gag caa gga gca tgt ctt tac ctg gtg gat gtt     5437
 Ala Ile Leu Asp Arg Glu Gln Gly Ala Cys Leu Tyr Leu Val Asp Val
    1695                1700                1705

 tat gcc ata gaa aaa tca act gct ttt ccc aga aca cag aga gca gag     5485
 Tyr Ala Ile Glu Lys Ser Thr Ala Phe Pro Arg Thr Gln Arg Ala Glu
1710                1715                1720                1725

 gta atg att ttg tag tcatttatta tttgttgatt tgctttttag aaaaatcatt     5540
 Val Met Ile Leu 


 ctctttatat ttactctcta taattgttta ccttcattgt ttattgttaa atttgtgaac   5600

 aggaacacct aaaaatgttc tgtcaaaggc taacagagag ttacataaac tttagtttta   5660

 atcttggttg caactaaaca acaaactttc ttttcacttt atattttact ttatagcaat   5720

 cacatatata aggttaagga gaa                                           5743




      <210> 32
      <211> 2774
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (153)..(2774)

      <400> 32
 atttcgtcga gaggcgccgc tggaccggga cgacctgtct agtccgttcg ccgccccacg     60

 tcccggtctg tggccacgcc tgcagctgga atggaggctc tctggaccct ttaaaaggca    120

 cccctgccct cctgaggtca gctgagcggt ta  atg cgg aag gtt aag aaa ctg     173
                                      Met Arg Lys Val Lys Lys Leu
                                        1               5

 cgc ctg gac aag gag aac acc gga agt tgg aga agc ttc tcg ctg aat      221
 Arg Leu Asp Lys Glu Asn Thr Gly Ser Trp Arg Ser Phe Ser Leu Asn
          10                  15                  20

 tcc gag ggg gct gag agg atg gcc acc acc ggg acc cca acg gcc gac      269
 Ser Glu Gly Ala Glu Arg Met Ala Thr Thr Gly Thr Pro Thr Ala Asp
      25                  30                  35

 cga ggc gac gca gcc gcc aca gat gac ccg gcc gcc cgc ttc cag gtg      317
 Arg Gly Asp Ala Ala Ala Thr Asp Asp Pro Ala Ala Arg Phe Gln Val
  40                  45                  50                  55

 cag aag cac tcg tgg gac ggg ctc cgg agc atc atc cac ggc agc cgc      365
 Gln Lys His Ser Trp Asp Gly Leu Arg Ser Ile Ile His Gly Ser Arg
                  60                  65                  70

 aag tac tcg ggc ctc att gtc aac aag gcg ccc cac gac ttc cag ttt      413
 Lys Tyr Ser Gly Leu Ile Val Asn Lys Ala Pro His Asp Phe Gln Phe
              75                  80                  85

 gtg cag aag acg gat gag tct ggg ccc cac tcc cac cgc ctc tac tac      461
 Val Gln Lys Thr Asp Glu Ser Gly Pro His Ser His Arg Leu Tyr Tyr
          90                  95                 100

 ctg ggt atg cca tat ggc agc cga gag aac tcc ctc ctc tac tct gag      509
 Leu Gly Met Pro Tyr Gly Ser Arg Glu Asn Ser Leu Leu Tyr Ser Glu
     105                 110                 115

 att ccc aag aag gtc cgg aaa gag gct ctg ctg ctc ctg tcc tgg aag      557
 Ile Pro Lys Lys Val Arg Lys Glu Ala Leu Leu Leu Leu Ser Trp Lys
 120                 125                 130                 135

 cag atg ctg gat cat ttc cag gcc acg ccc cac cat ggg gtc tac tct      605
 Gln Met Leu Asp His Phe Gln Ala Thr Pro His His Gly Val Tyr Ser
                 140                 145                 150

 cgg gag gag gag ctg ctg agg gag cgg aaa cgc ctg ggg gtc ttc ggc      653
 Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg Leu Gly Val Phe Gly
             155                 160                 165

 atc acc tcc tac gac ttc cac agc gag agt ggc ctc ttc ctc ttc cag      701
 Ile Thr Ser Tyr Asp Phe His Ser Glu Ser Gly Leu Phe Leu Phe Gln
         170                 175                 180

 gcc agc aac agc ctc ttc cac tgc cgc gac ggc ggc aag aac ggc ttc      749
 Ala Ser Asn Ser Leu Phe His Cys Arg Asp Gly Gly Lys Asn Gly Phe
     185                 190                 195

 atg gtg tcc cct atg aaa ccg ctg gaa atc aag acc cag tgc tca ggg      797
 Met Val Ser Pro Met Lys Pro Leu Glu Ile Lys Thr Gln Cys Ser Gly
 200                 205                 210                 215

 ccc cgg atg gac ccc aaa atc tgc cct gcc gac cct gcc ttc ttc tcc      845
 Pro Arg Met Asp Pro Lys Ile Cys Pro Ala Asp Pro Ala Phe Phe Ser
                 220                 225                 230

 ttc atc aat aac agc gac ctg tgg gtg gcc aac atc gag aca ggc gag      893
 Phe Ile Asn Asn Ser Asp Leu Trp Val Ala Asn Ile Glu Thr Gly Glu
             235                 240                 245

 gag cgg cgg ctg acc ttc tgc cac caa ggt tta tcc aat gtc ctg gat      941
 Glu Arg Arg Leu Thr Phe Cys His Gln Gly Leu Ser Asn Val Leu Asp
         250                 255                 260

 gac ccc aag tct gcg ggt gtg gcc acc ttc gtc ata cag gaa gag ttc      989
 Asp Pro Lys Ser Ala Gly Val Ala Thr Phe Val Ile Gln Glu Glu Phe
     265                 270                 275

 gac cgc ttc act ggg tac tgg tgg tgc ccc aca gcc tcc tgg gaa ggt     1037
 Asp Arg Phe Thr Gly Tyr Trp Trp Cys Pro Thr Ala Ser Trp Glu Gly
 280                 285                 290                 295

 tca gag ggc ctc aag acg ctg cga atc ctg tat gag gaa gtc gat gag     1085
 Ser Glu Gly Leu Lys Thr Leu Arg Ile Leu Tyr Glu Glu Val Asp Glu
                 300                 305                 310

 tcc gag gtg gag gtc att cac gtc ccc tct cct gcg cta gaa gaa agg     1133
 Ser Glu Val Glu Val Ile His Val Pro Ser Pro Ala Leu Glu Glu Arg
             315                 320                 325

 aag acg gac tcg tat cgg tac ccc agg aca ggc agc aag aat ccc aag     1181
 Lys Thr Asp Ser Tyr Arg Tyr Pro Arg Thr Gly Ser Lys Asn Pro Lys
         330                 335                 340

 att gcc ttg aaa ctg gct gag ttc cag act gac agc cag ggc aag atc     1229
 Ile Ala Leu Lys Leu Ala Glu Phe Gln Thr Asp Ser Gln Gly Lys Ile
     345                 350                 355

 gtc tcg acc cag gag aag gag ctg gtg cag ccc ttc agc tcg ctg ttc     1277
 Val Ser Thr Gln Glu Lys Glu Leu Val Gln Pro Phe Ser Ser Leu Phe
 360                 365                 370                 375

 ccg aag gtg gag tac atc gcc agg gcc ggg tgg acc cgg gat ggc aaa     1325
 Pro Lys Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr Arg Asp Gly Lys
                 380                 385                 390

 tac gcc tgg gcc atg ttc ctg gac cgg ccc cag cag tgg ctc cag ctc     1373
 Tyr Ala Trp Ala Met Phe Leu Asp Arg Pro Gln Gln Trp Leu Gln Leu
             395                 400                 405

 gtc ctc ctc ccc ccg gcc ctg ttc atc ccg agc aca gag aat gag gag     1421
 Val Leu Leu Pro Pro Ala Leu Phe Ile Pro Ser Thr Glu Asn Glu Glu
         410                 415                 420

 cag cgg cta gcc tct gcc aga gct gtc ccc agg aat gtc cag ccg tat     1469
 Gln Arg Leu Ala Ser Ala Arg Ala Val Pro Arg Asn Val Gln Pro Tyr
     425                 430                 435

 gtg gtg tac gag gag gtc acc aac gtc tgg atc aat gtt cat gac atc     1517
 Val Val Tyr Glu Glu Val Thr Asn Val Trp Ile Asn Val His Asp Ile
 440                 445                 450                 455

 ttc tat ccc ttc ccc caa tca gag gga gag gac gag ctc tgc ttt ctc     1565
 Phe Tyr Pro Phe Pro Gln Ser Glu Gly Glu Asp Glu Leu Cys Phe Leu
                 460                 465                 470

 cgc gcc aat gaa tgc aag acc ggc ttc tgc cat ttg tac aaa gtc acc     1613
 Arg Ala Asn Glu Cys Lys Thr Gly Phe Cys His Leu Tyr Lys Val Thr
             475                 480                 485

 gcc gtt tta aaa tcc cag ggc tac gat tgg agt gag ccc ttc agc ccc     1661
 Ala Val Leu Lys Ser Gln Gly Tyr Asp Trp Ser Glu Pro Phe Ser Pro
         490                 495                 500

 ggg gaa ggt gag cag agc ctg acg aat gct atc tgg gtc aat gag gag     1709
 Gly Glu Gly Glu Gln Ser Leu Thr Asn Ala Ile Trp Val Asn Glu Glu
     505                 510                 515

 acc aag ctg gtg tac ttc cag ggc acc aag gac acg ccg ctg gag cac     1757
 Thr Lys Leu Val Tyr Phe Gln Gly Thr Lys Asp Thr Pro Leu Glu His
 520                 525                 530                 535

 cac ctc tac gtg gtc agc tat gag gcg gcc ggc gag atc gta cgc ctc     1805
 His Leu Tyr Val Val Ser Tyr Glu Ala Ala Gly Glu Ile Val Arg Leu
                 540                 545                 550

 acc acg ccc ggc ttc tcc cat agc tgc tcc atg agc cag aac ttc gac     1853
 Thr Thr Pro Gly Phe Ser His Ser Cys Ser Met Ser Gln Asn Phe Asp
             555                 560                 565

 atg ttc gtc agc cac tac agc agc gtg agc acg ccg ccc tgc gtg cac     1901
 Met Phe Val Ser His Tyr Ser Ser Val Ser Thr Pro Pro Cys Val His
         570                 575                 580

 gtc tac aag ctg agc ggc ccc gac gac gac ccc ctg cac aag cag ccc     1949
 Val Tyr Lys Leu Ser Gly Pro Asp Asp Asp Pro Leu His Lys Gln Pro
     585                 590                 595

 cgc ttc tgg gct agc atg atg gag gca gcc aag atc ttc cat ttc cac     1997
 Arg Phe Trp Ala Ser Met Met Glu Ala Ala Lys Ile Phe His Phe His
 600                 605                 610                 615

 acg cgc tcg gat gtg cgg ctc tac ggc atg atc tac aag ccc cac gcc     2045
 Thr Arg Ser Asp Val Arg Leu Tyr Gly Met Ile Tyr Lys Pro His Ala
                 620                 625                 630

 ttg cag cca ggg aag aag cac ccc acc gtc ctc ttt gta tat gga ggc     2093
 Leu Gln Pro Gly Lys Lys His Pro Thr Val Leu Phe Val Tyr Gly Gly
             635                 640                 645

 ccc cag gtg cag ctg gtg aat aac tcc ttc aaa ggc atc aag tac ttg     2141
 Pro Gln Val Gln Leu Val Asn Asn Ser Phe Lys Gly Ile Lys Tyr Leu
         650                 655                 660

 cgg ctc aac aca ctg gcc tcc ctg ggc tac gcc gtg gtt gtg att gac     2189
 Arg Leu Asn Thr Leu Ala Ser Leu Gly Tyr Ala Val Val Val Ile Asp
     665                 670                 675

 ggc agg ggc tcc tgt cag cga ggg ctt cgg ttc gaa ggg gcc ctg aaa     2237
 Gly Arg Gly Ser Cys Gln Arg Gly Leu Arg Phe Glu Gly Ala Leu Lys
 680                 685                 690                 695

 aac caa atg ggc cag gtg gag atc gag gac cag gtg gag ggc ctg cag     2285
 Asn Gln Met Gly Gln Val Glu Ile Glu Asp Gln Val Glu Gly Leu Gln
                 700                 705                 710

 ttc gtg gcc gag aag tat ggc ttc atc gac ctg agc cga gtt gcc atc     2333
 Phe Val Ala Glu Lys Tyr Gly Phe Ile Asp Leu Ser Arg Val Ala Ile
             715                 720                 725

 cat ggc tgg tcc tac ggg ggc ttc ctc tcg ctc atg ggg cta atc cac     2381
 His Gly Trp Ser Tyr Gly Gly Phe Leu Ser Leu Met Gly Leu Ile His
         730                 735                 740

 aag ccc cag gtg ttc aag gtg gcc atc gcg ggt gcc ccg gtc acc gtc     2429
 Lys Pro Gln Val Phe Lys Val Ala Ile Ala Gly Ala Pro Val Thr Val
     745                 750                 755

 tgg atg gcc tac gac aca ggg tac act gag cgc tac atg gac gtc cct     2477
 Trp Met Ala Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met Asp Val Pro
 760                 765                 770                 775

 gag aac aac cag cac ggc tat gag gcg ggt tcc gtg gcc ctg cac gtg     2525
 Glu Asn Asn Gln His Gly Tyr Glu Ala Gly Ser Val Ala Leu His Val
                 780                 785                 790

 gag aag ctg ccc aat gag ccc aac cgc ttg ctt atc ctc cac ggc ttc     2573
 Glu Lys Leu Pro Asn Glu Pro Asn Arg Leu Leu Ile Leu His Gly Phe
             795                 800                 805

 ctg gac gaa aac gtg cac ttt ttc cac aca aac ttc ctc gtc tcc caa     2621
 Leu Asp Glu Asn Val His Phe Phe His Thr Asn Phe Leu Val Ser Gln
         810                 815                 820

 ctg atc cga gca ggg aaa cct tac cag ctc cag gtg gcc ctg cct cct     2669
 Leu Ile Arg Ala Gly Lys Pro Tyr Gln Leu Gln Val Ala Leu Pro Pro
     825                 830                 835

 gtc tcc ccg cag atc tac ccc aac gag aga cac agt att cgc tgc ccc     2717
 Val Ser Pro Gln Ile Tyr Pro Asn Glu Arg His Ser Ile Arg Cys Pro
 840                 845                 850                 855

 gag tcg ggc gag cac tat gaa gtc acg ttg ctg cac ttt cta cag gaa     2765
 Glu Ser Gly Glu His Tyr Glu Val Thr Leu Leu His Phe Leu Gln Glu
                 860                 865                 870

 tac ctc tga                                                         2774
 Tyr Leu 






      <210> 33
      <211> 2542
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (305)..(1438)

      <400> 33
 cttttccatt aatccactgg tttagtttcc agaacgcaat gtcagacctg aggtgacaga     60

 aaagggaaaa cgtgagagag tgtcttcttc cctgaagaga ggtgggcctg aggcttgaca    120

 gtggcgctgc ctgagtgacc tagccgctgg gctgggccct ggacagctga tcccaggttc    180

 ctgcacttgt cgccaccctt ccgtagtcca caggcctgat ggcggcggct gagccgatgg    240

 gcccggcaca ggttcccatg aactcagaag taattgtgga ccctatacag gttgttggca    300

 tgga atg gag gat gaa gag ata cct ttt gag cag agc ttt tct ata gga     349
      Met Glu Asp Glu Glu Ile Pro Phe Glu Gln Ser Phe Ser Ile Gly
        1               5                  10                  15

 atg tca cag atc agg att ccc aag gga ggt cct tct act cag aag gct      397
 Met Ser Gln Ile Arg Ile Pro Lys Gly Gly Pro Ser Thr Gln Lys Ala
                  20                  25                  30

 tac ccc tgt ggg aca tgt ggc ctg gtc tta aaa gac att ttg cac ttg      445
 Tyr Pro Cys Gly Thr Cys Gly Leu Val Leu Lys Asp Ile Leu His Leu
              35                  40                  45

 gct gag cac cag gaa aca cac cca ggg cag aaa cca tac atg tgt gtg      493
 Ala Glu His Gln Glu Thr His Pro Gly Gln Lys Pro Tyr Met Cys Val
          50                  55                  60

 ctg tgt ggg aaa cag ttc tgg ttc agt gca aac ctt cac cag cac cag      541
 Leu Cys Gly Lys Gln Phe Trp Phe Ser Ala Asn Leu His Gln His Gln
      65                  70                  75

 aag cag cac agt gga gag aaa ccc ttt aga agt gat aag agc agg ccc      589
 Lys Gln His Ser Gly Glu Lys Pro Phe Arg Ser Asp Lys Ser Arg Pro
  80                  85                  90                  95

 ttt ctt ctg aac aac tgt gct gtg caa tca ttg gag atg tct ttt gtg      637
 Phe Leu Leu Asn Asn Cys Ala Val Gln Ser Leu Glu Met Ser Phe Val
                 100                 105                 110

 aca ggg gag gct tgt aag gac ttc cta gcc agc tca agc att ttc gag      685
 Thr Gly Glu Ala Cys Lys Asp Phe Leu Ala Ser Ser Ser Ile Phe Glu
             115                 120                 125

 cac cat gcc cct cac aat gag tgg aag cca cac agc aac acc aag tgt      733
 His His Ala Pro His Asn Glu Trp Lys Pro His Ser Asn Thr Lys Cys
         130                 135                 140

 gag gag gcc tct cac tgt gga aaa agg cat tac aaa tgc agt gaa tgt      781
 Glu Glu Ala Ser His Cys Gly Lys Arg His Tyr Lys Cys Ser Glu Cys
     145                 150                 155

 ggg aaa acc ttc agc cgc aaa gac tca ctt gtt caa cac cag aga gtc      829
 Gly Lys Thr Phe Ser Arg Lys Asp Ser Leu Val Gln His Gln Arg Val
 160                 165                 170                 175

 cac act gga gaa agg cct tat gag tgc ggt gaa tgt ggg aaa acc ttt      877
 His Thr Gly Glu Arg Pro Tyr Glu Cys Gly Glu Cys Gly Lys Thr Phe
                 180                 185                 190

 agc cgc aaa ccc ata ctt gct cag cac cag aga atc cac act gga gaa      925
 Ser Arg Lys Pro Ile Leu Ala Gln His Gln Arg Ile His Thr Gly Glu
             195                 200                 205

 atg cct tat gag tgt ggc ata tgt ggg aaa gtt ttt aat cat agc tct      973
 Met Pro Tyr Glu Cys Gly Ile Cys Gly Lys Val Phe Asn His Ser Ser
         210                 215                 220

 aac ctt att gta cat caa aga gta cac act gga gca agg cct tac aag     1021
 Asn Leu Ile Val His Gln Arg Val His Thr Gly Ala Arg Pro Tyr Lys
     225                 230                 235

 tgc agt gaa tgt ggg aaa gcc tat agt cac aaa tct aca ctt gtt cag     1069
 Cys Ser Glu Cys Gly Lys Ala Tyr Ser His Lys Ser Thr Leu Val Gln
 240                 245                 250                 255

 cat gag agt atc cat act gga gaa agg cca tat gag tgc agc gaa tgt     1117
 His Glu Ser Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys
                 260                 265                 270

 gga aaa tac ttt ggt cac aaa tac aga ctc att aaa cat tgg agt gtt     1165
 Gly Lys Tyr Phe Gly His Lys Tyr Arg Leu Ile Lys His Trp Ser Val
             275                 280                 285

 cat act gga gca agg cct tat gag tgc atc gca tgt ggg aag ttc ttt     1213
 His Thr Gly Ala Arg Pro Tyr Glu Cys Ile Ala Cys Gly Lys Phe Phe
         290                 295                 300

 agc caa agc tct gac ctt att gca cat caa aga gtt cat aat ggt gaa     1261
 Ser Gln Ser Ser Asp Leu Ile Ala His Gln Arg Val His Asn Gly Glu
     305                 310                 315

 aag cct tat gtg tgc agt gaa tgt gga aaa gcc ttt agc cac aaa cat     1309
 Lys Pro Tyr Val Cys Ser Glu Cys Gly Lys Ala Phe Ser His Lys His
 320                 325                 330                 335

 gta ctt gtt cag cat cat aga att cac act gga gaa agg cca tat aag     1357
 Val Leu Val Gln His His Arg Ile His Thr Gly Glu Arg Pro Tyr Lys
                 340                 345                 350

 tgc agt gaa tgt ggg aag gcc ttc agg cag agg gct tcc ctc atc cgc     1405
 Cys Ser Glu Cys Gly Lys Ala Phe Arg Gln Arg Ala Ser Leu Ile Arg
             355                 360                 365

 cac tgg aaa att cac act gga gaa agg cct tag gatgggag ataattccgt     1456
 His Trp Lys Ile His Thr Gly Glu Arg Pro 
         370                 375

 ttccttgttc aacataataa ctgacatcag agagaagctc caagcatagc ctttatgtgt   1516

 agccgacagc cagaagtaga actttataca ctcaaacact caccctgggg aggttcttcc   1576

 gagtgccagc tatatgggaa gccttctgga gctatgctga attttctaga ctcttgctgg   1636

 aatttcgtca aggcagtgcc tgttagaagc catctgtctt tgtgctggaa gagtcctgcc   1696

 ttgtgccaaa gtaaccccaa tgtgtttcaa aagacagacc tctgtactat tcccttccct   1756

 ggagggaatc atcagtagcc tgaggccatc aaggattctc actttttttc tgccccacta   1816

 ctggtttaag catgagcatg acccagtttt agccagaaaa atgggagctt tgttctgctg   1876

 accactggca gaggtttccc ttcatggata tagttgatct cacatggcac ttgggacgaa   1936

 tttttctagc cttcaagaca cctgacctga aattggctgc ctcatatgct aggttcttgc   1996

 aaccaaatgc cttaatcttt tagattatct gaacatcttg aggtttctgt tcgctttgtg   2056

 ggttgggttg agaacagaat tgacgctacg ccagtatgaa gggaacgaac agctttcgtg   2116

 agagctccaa ctatctgtat ctctgcaagt gactcagtcc ggatggcaaa gactagctct   2176

 tattctagtg tcaagctgca cttacttgac tgcttcagct ctcctaggaa cagattgcca   2236

 gtctttgctc aggcctaatc ttattggtct atatgtacag atctctcctg ctgtaactcg   2296

 aggtcacccc aagagcagct gggccatctg ttgtgcatca tctactacct gtgctctgcg   2356

 gacacaaacc gtgaacttac acgctcccct tgatttccca ggcaaggatt acctgtacta   2416

 cttccccaag gctcccttga agcgcagaaa tactgaaacc tccgctggga cccctgtaac   2476

 gaactctcta gcaagatcaa gtcactcacg aagcggccgc acagaatcat tgggtatgct   2536

 ctaccg                                                              2542




      <210> 34
      <211> 799
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (189)..(710)

      <400> 34
 ccaagctggc tagcgtttaa acttaagctt ggtaccgagc tcggatccac tagtccagtg     60

 tggtggaatt ccttaaactg aagcaagttc ggtggacgcc ggcggcgccc tgatctaaag    120

 aaacgactca gggactgcgg cgcttgcacg tcaacgggag gtgtgagccc aaaggtctgg    180

 acccagaa atg gga cgt cgg tca tca gat act gaa gaa gaa agc aga agc     230
          Met Gly Arg Arg Ser Ser Asp Thr Glu Glu Glu Ser Arg Ser
            1               5                  10

 aag aga aaa aag aaa cac cgt aga cgg tcc tcc tcg agc agt tct tca      278
 Lys Arg Lys Lys Lys His Arg Arg Arg Ser Ser Ser Ser Ser Ser Ser
  15                  20                  25                  30

 gat agt aga aca tac agc cga aag aaa gga gga agg aaa tca aga tca      326
 Asp Ser Arg Thr Tyr Ser Arg Lys Lys Gly Gly Arg Lys Ser Arg Ser
                  35                  40                  45

 aag tca aga tct tgg tcc aga gat ctt cag cct cgt tca cat tct tat      374
 Lys Ser Arg Ser Trp Ser Arg Asp Leu Gln Pro Arg Ser His Ser Tyr
              50                  55                  60

 gat aga aga cgc agg cat cga tca agc agt agc tct tct tat ggc tcc      422
 Asp Arg Arg Arg Arg His Arg Ser Ser Ser Ser Ser Ser Tyr Gly Ser
          65                  70                  75

 aga agg aaa cga agt cga agt cgt tca agg ggt cga ggg aaa tcc tat      470
 Arg Arg Lys Arg Ser Arg Ser Arg Ser Arg Gly Arg Gly Lys Ser Tyr
      80                  85                  90

 aga gtt cag agg tct agg tca aaa agc aga aca aga agg tcc agg tca      518
 Arg Val Gln Arg Ser Arg Ser Lys Ser Arg Thr Arg Arg Ser Arg Ser
  95                 100                 105                 110

 aga cct cgt ctc cgt tct cat agt cgt agc agt gaa agg tcc agt cac      566
 Arg Pro Arg Leu Arg Ser His Ser Arg Ser Ser Glu Arg Ser Ser His
                 115                 120                 125

 aga aga acg cgt agt cgg tct cgg gat aga gaa cga cgt aag ggc aga      614
 Arg Arg Thr Arg Ser Arg Ser Arg Asp Arg Glu Arg Arg Lys Gly Arg
             130                 135                 140

 gat aaa gag aaa aga gaa aag gga gag gat aaa ggg aag gac aag gaa      662
 Asp Lys Glu Lys Arg Glu Lys Gly Glu Asp Lys Gly Lys Asp Lys Glu
         145                 150                 155

 tac ata aca tca aac gtg gga atc tgg aaa cat caa agc tgg att tag      710
 Tyr Ile Thr Ser Asn Val Gly Ile Trp Lys His Gln Ser Trp Ile 
     160                 165                 170

 aacatcttgc caccagctga acaggccaaa gccagactac agctggttct tgaagctgct    770

 gcaaaagctg atgaagcatt gaaagccaa                                      799




      <210> 35
      <211> 2191
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(1944)

      <400> 35
 gaccaccttc agcaacttga acatgaggtg gacccccctt tcacttccag gaaggtacat     60
                                                                 
 atg gaa act aca gtg tcc aga ccg gtc ctt tct cca acc cac atc aac      108
 Met Glu Thr Thr Val Ser Arg Pro Val Leu Ser Pro Thr His Ile Asn
   1               5                  10                  15

 gct aca gct tct gaa aca ttc aca gta ctt cag caa agg atg aga ata      156
 Ala Thr Ala Ser Glu Thr Phe Thr Val Leu Gln Gln Arg Met Arg Ile
              20                  25                  30

 gtt gag gaa cag acc agt tca ctg agg gat gac cta ata atg ttg gat      204
 Val Glu Glu Gln Thr Ser Ser Leu Arg Asp Asp Leu Ile Met Leu Asp
          35                  40                  45

 ttt ggt gaa aaa agg tcc cat gta aac agt ata aag gaa aga acg tca      252
 Phe Gly Glu Lys Arg Ser His Val Asn Ser Ile Lys Glu Arg Thr Ser
      50                  55                  60

 tca gtt ggt ttg cct agt gtt att cca aac tct aca cgc cgt gtg agc      300
 Ser Val Gly Leu Pro Ser Val Ile Pro Asn Ser Thr Arg Arg Val Ser
  65                  70                  75                  80

 ttt gca cct aac ctg cct tct atg aaa aca tct cag gat att gga gac      348
 Phe Ala Pro Asn Leu Pro Ser Met Lys Thr Ser Gln Asp Ile Gly Asp
                  85                  90                  95

 tct agg atc tct cta aag act ctt ttg aat gct att aaa acc atg gag      396
 Ser Arg Ile Ser Leu Lys Thr Leu Leu Asn Ala Ile Lys Thr Met Glu
             100                 105                 110

 gga aga ctg gaa ggc aaa ata gag att cta gcc tca aga cct tta ata      444
 Gly Arg Leu Glu Gly Lys Ile Glu Ile Leu Ala Ser Arg Pro Leu Ile
         115                 120                 125

 aat gat gaa tca cca aat ttt ctt aaa cag gac tcg gtg aaa tct att      492
 Asn Asp Glu Ser Pro Asn Phe Leu Lys Gln Asp Ser Val Lys Ser Ile
     130                 135                 140

 ctt gaa aga agt aaa gag gag ctg tcc cga aca gtg aag tgt cgt aat      540
 Leu Glu Arg Ser Lys Glu Glu Leu Ser Arg Thr Val Lys Cys Arg Asn
 145                 150                 155                 160

 gcg gcc ctg aaa gag agt cag aag ttg aaa gaa gac ctc gag gct gtg      588
 Ala Ala Leu Lys Glu Ser Gln Lys Leu Lys Glu Asp Leu Glu Ala Val
                 165                 170                 175

 gag gac agg gaa aac aag aag gca agg aat cag tcc ctt ctg acc gtg      636
 Glu Asp Arg Glu Asn Lys Lys Ala Arg Asn Gln Ser Leu Leu Thr Val
             180                 185                 190

 gga aac ttt cag cga caa ttg gca gaa gct aaa gaa gac aac tgc aaa      684
 Gly Asn Phe Gln Arg Gln Leu Ala Glu Ala Lys Glu Asp Asn Cys Lys
         195                 200                 205

 gtc aca atc atg ttg gag aat gtg ctg gct tct cac agt aag atg caa      732
 Val Thr Ile Met Leu Glu Asn Val Leu Ala Ser His Ser Lys Met Gln
     210                 215                 220

 ggt gct ctg gag aaa gta caa ata gag ctt ggg cgg agg gat tca gag      780
 Gly Ala Leu Glu Lys Val Gln Ile Glu Leu Gly Arg Arg Asp Ser Glu
 225                 230                 235                 240

 att gca ggc ctc aag aaa gaa agg gat ctc aat caa cag agg gtg cag      828
 Ile Ala Gly Leu Lys Lys Glu Arg Asp Leu Asn Gln Gln Arg Val Gln
                 245                 250                 255

 aag ctg gaa gct gaa gtg gac cag tgg cag gcc agg atg ctt gtc atg      876
 Lys Leu Glu Ala Glu Val Asp Gln Trp Gln Ala Arg Met Leu Val Met
             260                 265                 270

 gag gac cag cac aac agt gag att gaa tct cta caa aaa gct cta ggt      924
 Glu Asp Gln His Asn Ser Glu Ile Glu Ser Leu Gln Lys Ala Leu Gly
         275                 280                 285

 gta gct aga gaa gac aac agg aaa ctt gct atg agt ctg gaa caa gct      972
 Val Ala Arg Glu Asp Asn Arg Lys Leu Ala Met Ser Leu Glu Gln Ala
     290                 295                 300

 ctc cag aca aat aat cat ctg caa aca aag cta gat cac att caa gag     1020
 Leu Gln Thr Asn Asn His Leu Gln Thr Lys Leu Asp His Ile Gln Glu
 305                 310                 315                 320

 caa ttg gaa agc aaa gaa ctt gag cga cag aat ttg gaa acc ttc aaa     1068
 Gln Leu Glu Ser Lys Glu Leu Glu Arg Gln Asn Leu Glu Thr Phe Lys
                 325                 330                 335

 gac cgg atg act gaa gag tcc aaa gtg gaa gca gaa ttg cat gct gaa     1116
 Asp Arg Met Thr Glu Glu Ser Lys Val Glu Ala Glu Leu His Ala Glu
             340                 345                 350

 cgc ata gaa gct cta aga aag cag ttt caa acc gag aga gaa act aca     1164
 Arg Ile Glu Ala Leu Arg Lys Gln Phe Gln Thr Glu Arg Glu Thr Thr
         355                 360                 365

 aag aaa gtg gca caa cgg gaa gtg gct gag ctg aag aaa gcc ctt gat     1212
 Lys Lys Val Ala Gln Arg Glu Val Ala Glu Leu Lys Lys Ala Leu Asp
     370                 375                 380

 gaa gct aac ttc aga tca gtg gaa gtg tcc cgg acc aac cga gag ctg     1260
 Glu Ala Asn Phe Arg Ser Val Glu Val Ser Arg Thr Asn Arg Glu Leu
 385                 390                 395                 400

 cga cag aaa ctt gca gag cta gaa aaa ata cta gaa agt aac aag gag     1308
 Arg Gln Lys Leu Ala Glu Leu Glu Lys Ile Leu Glu Ser Asn Lys Glu
                 405                 410                 415

 aaa ata aag aat caa aag acc caa att aag ctc cac ttg tca gct aag     1356
 Lys Ile Lys Asn Gln Lys Thr Gln Ile Lys Leu His Leu Ser Ala Lys
             420                 425                 430

 gcg aat aat gct cag aat ata gaa agg atg aag caa ata gaa aaa gaa     1404
 Ala Asn Asn Ala Gln Asn Ile Glu Arg Met Lys Gln Ile Glu Lys Glu
         435                 440                 445

 ttg aag caa atg gag cta att aag gat caa tat caa aaa aag aac tat     1452
 Leu Lys Gln Met Glu Leu Ile Lys Asp Gln Tyr Gln Lys Lys Asn Tyr
     450                 455                 460

 gaa cag tct ttg agt atc cag aga ttt gtg tgt gaa atg act aac ctg     1500
 Glu Gln Ser Leu Ser Ile Gln Arg Phe Val Cys Glu Met Thr Asn Leu
 465                 470                 475                 480

 cag aaa gag atg cag atg ttg gct aag agc caa tat gat gcc tca gtg     1548
 Gln Lys Glu Met Gln Met Leu Ala Lys Ser Gln Tyr Asp Ala Ser Val
                 485                 490                 495

 cgg aat aaa cag caa gag ctg cac cta gaa gca gag cgg aaa ata agg     1596
 Arg Asn Lys Gln Gln Glu Leu His Leu Glu Ala Glu Arg Lys Ile Arg
             500                 505                 510

 cag gag cta gag aat cgg tgc cag gaa ttg gaa gaa act gtc aga cac     1644
 Gln Glu Leu Glu Asn Arg Cys Gln Glu Leu Glu Glu Thr Val Arg His
         515                 520                 525

 ctg aag aaa tgt aaa gag gca aca gag aat acg ctg aaa gaa gcc agt     1692
 Leu Lys Lys Cys Lys Glu Ala Thr Glu Asn Thr Leu Lys Glu Ala Ser
     530                 535                 540

 gtg gaa tca gaa cag ata aca gct aat ctg gaa gaa gct cat cgc tgg     1740
 Val Glu Ser Glu Gln Ile Thr Ala Asn Leu Glu Glu Ala His Arg Trp
 545                 550                 555                 560

 ttt aag cac agg ttt gat ggt cta caa ctt gag ctg aca aaa aac cgg     1788
 Phe Lys His Arg Phe Asp Gly Leu Gln Leu Glu Leu Thr Lys Asn Arg
                 565                 570                 575

 ttg cag agg cct tct ggg gaa gac agg tgg cag gaa aag gac caa gat     1836
 Leu Gln Arg Pro Ser Gly Glu Asp Arg Trp Gln Glu Lys Asp Gln Asp
             580                 585                 590

 gta aaa cat gat gtc atg tcc aac caa tct gtt ctg cat cga tgg gag     1884
 Val Lys His Asp Val Met Ser Asn Gln Ser Val Leu His Arg Trp Glu
         595                 600                 605

 aga aaa cag aat ctt agg ccc atg ccc aag aag tat cat tct gag gta     1932
 Arg Lys Gln Asn Leu Arg Pro Met Pro Lys Lys Tyr His Ser Glu Val
     610                 615                 620

 cag agg aag tga tgt ccttgacaag ggagcttctt tatgtgtagc tacactccat     1987
 Gln Arg Lys 
 625

 gattccaaga gcccagcagc cggggctggc ctgtttctag agtcataaga acatgaagtc   2047

 tttgatgtgg gctgaagatt ttggacctga gtttatcact ttatgaactc ttatatcagt   2107

 acaaaactac cccttttttt gtcccttttc acattttcca cccaataaat ttgtgttaat   2167

 ttgttgtatg ataaaaaaaa aaaa                                          2191




      <210> 36
      <211> 8546
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (409)..(8022)

      <220>
      <221> misc_feature
      <222> (1)...(8546)
      <223> n = a,t,c or g

      <400> 36
 cctccaagtg tcattggtcc taaatctgaa aatcttaccg tcgtggtgaa caatttcatc     60

 tctttgacct gtgaggtctc tggttttcca cctcctgacc tcagctggct caagaatgaa    120

 cagcccatca aactgaacac aaatactctc attgtgcctg gnggtcgaac tctacagatt    180

 attcgggcca aggtatcaga tggtggtgaa tacacttgta tagctatcaa tcaagctggc    240

 gaaagcaaga aaaagttttc cctgactgtt tatgtgcccc caagcattaa agaccatgac    300

 agtgaatctc tttctgtagt taatgtaaga gagggaactt ctgtgtcttt ggagtgngag    360

 tcgaacgctg tgccacctcc agtcatcact tggtataaga atgggcgg atg ata aca     417
                                                      Met Ile Thr
                                                        1

 gag tct act cat gtg gag att tta gct gat gga caa atg cta cac att      465
 Glu Ser Thr His Val Glu Ile Leu Ala Asp Gly Gln Met Leu His Ile
       5                  10                  15

 aag aaa gct gag gta tct gac aca ggc cag tat gta tgt aga gct ata      513
 Lys Lys Ala Glu Val Ser Asp Thr Gly Gln Tyr Val Cys Arg Ala Ile
  20                  25                  30                  35

 aat gta gca gga cgg gat gat aaa aat ttc cac ctc aat gta tat gtg      561
 Asn Val Ala Gly Arg Asp Asp Lys Asn Phe His Leu Asn Val Tyr Val
                  40                  45                  50

 cca ccc agt att gaa gga cct gaa aga gaa gtg att gtg gag acg atc      609
 Pro Pro Ser Ile Glu Gly Pro Glu Arg Glu Val Ile Val Glu Thr Ile
              55                  60                  65

 agc aat cct gtg aca tta aca tgt gat gcc act ggg atc cca cct ccc      657
 Ser Asn Pro Val Thr Leu Thr Cys Asp Ala Thr Gly Ile Pro Pro Pro
          70                  75                  80

 acg ata gca tgg tta aag aac cac aag cgc ata gaa aat tct gac tca      705
 Thr Ile Ala Trp Leu Lys Asn His Lys Arg Ile Glu Asn Ser Asp Ser
      85                  90                  95

 ctg gaa gtt cgt att ttg tct gga ggt agc aaa ctc cag att gcc cgg      753
 Leu Glu Val Arg Ile Leu Ser Gly Gly Ser Lys Leu Gln Ile Ala Arg
 100                 105                 110                 115

 tct cag cat tca gat agt gga aac tat aca tgt att gct tca aat atg      801
 Ser Gln His Ser Asp Ser Gly Asn Tyr Thr Cys Ile Ala Ser Asn Met
                 120                 125                 130

 gag gga aaa gcc cag aaa tat tac ttt ctt tca att caa gtt cct cca      849
 Glu Gly Lys Ala Gln Lys Tyr Tyr Phe Leu Ser Ile Gln Val Pro Pro
             135                 140                 145

 agt gtt gct ggt gct gaa att cca agt gat gtc agt gtc ctt cta gga      897
 Ser Val Ala Gly Ala Glu Ile Pro Ser Asp Val Ser Val Leu Leu Gly
         150                 155                 160

 gaa aat gtt gag ctg gtc tgc aat gca aat ggc att cct act cca ctt      945
 Glu Asn Val Glu Leu Val Cys Asn Ala Asn Gly Ile Pro Thr Pro Leu
     165                 170                 175

 att caa tgg ctt aaa gat gga aag ccc ata gct agt ggt gaa aca gaa      993
 Ile Gln Trp Leu Lys Asp Gly Lys Pro Ile Ala Ser Gly Glu Thr Glu
 180                 185                 190                 195

 aga atc cga gtg agt gca aat ggc agc aca tta aac att tat gga gct     1041
 Arg Ile Arg Val Ser Ala Asn Gly Ser Thr Leu Asn Ile Tyr Gly Ala
                 200                 205                 210

 ctt aca tct gac acg ggg aaa tac aca tgt gtt gct act aat ccc gct     1089
 Leu Thr Ser Asp Thr Gly Lys Tyr Thr Cys Val Ala Thr Asn Pro Ala
             215                 220                 225

 gga gaa gaa gac cga att ttt aac ttg aat gtc tat gtt aca cct aca     1137
 Gly Glu Glu Asp Arg Ile Phe Asn Leu Asn Val Tyr Val Thr Pro Thr
         230                 235                 240

 att agg ggt aat aaa gat gaa gca gag aaa cta atg act tta gtg gat     1185
 Ile Arg Gly Asn Lys Asp Glu Ala Glu Lys Leu Met Thr Leu Val Asp
     245                 250                 255

 act tca ata aat att gaa tgc aga gcc aca ggg acg cct cca cca cag     1233
 Thr Ser Ile Asn Ile Glu Cys Arg Ala Thr Gly Thr Pro Pro Pro Gln
 260                 265                 270                 275

 ata aac tgg ctg aag aat gga ctt cct ctg cct ctc tcc tcc cat atc     1281
 Ile Asn Trp Leu Lys Asn Gly Leu Pro Leu Pro Leu Ser Ser His Ile
                 280                 285                 290

 cgg tta ctg gca gca gga caa gtt atc agg att gtg aga gct cag gtg     1329
 Arg Leu Leu Ala Ala Gly Gln Val Ile Arg Ile Val Arg Ala Gln Val
             295                 300                 305

 tct gat gtc gct gtg tat act tgt gtg gcc tcc aac aga gct ggg gtg     1377
 Ser Asp Val Ala Val Tyr Thr Cys Val Ala Ser Asn Arg Ala Gly Val
         310                 315                 320

 gat aat aag cat tac aat ctt caa gtg ttt gca cca cca aat atg gac     1425
 Asp Asn Lys His Tyr Asn Leu Gln Val Phe Ala Pro Pro Asn Met Asp
     325                 330                 335

 aat tca atg ggg aca gag gaa atc aca gtt ctc aaa ggt agt tcc acc     1473
 Asn Ser Met Gly Thr Glu Glu Ile Thr Val Leu Lys Gly Ser Ser Thr
 340                 345                 350                 355

 tct atg gca tgc att act gat gga acc cca gct ccc agt atg gcc tgg     1521
 Ser Met Ala Cys Ile Thr Asp Gly Thr Pro Ala Pro Ser Met Ala Trp
                 360                 365                 370

 ctt aga gat ggc cag cct ctg ggg ctt gat gcc cat ctg aca gtc agc     1569
 Leu Arg Asp Gly Gln Pro Leu Gly Leu Asp Ala His Leu Thr Val Ser
             375                 380                 385

 acc cat gga atg gtc ctg cag ctc ctc aaa gca gag act gaa gat tcg     1617
 Thr His Gly Met Val Leu Gln Leu Leu Lys Ala Glu Thr Glu Asp Ser
         390                 395                 400

 gga aag tac acc tgc att gcc tca aat gaa gct gga gaa gtc agc aag     1665
 Gly Lys Tyr Thr Cys Ile Ala Ser Asn Glu Ala Gly Glu Val Ser Lys
     405                 410                 415

 cac ttt atc ctc aag gtc cta gaa cca cct cac att aat gga tct gaa     1713
 His Phe Ile Leu Lys Val Leu Glu Pro Pro His Ile Asn Gly Ser Glu
 420                 425                 430                 435

 gaa cat gaa gag ata tca gta att gtt aat aac cca ctt gaa ctt acc     1761
 Glu His Glu Glu Ile Ser Val Ile Val Asn Asn Pro Leu Glu Leu Thr
                 440                 445                 450

 tgc att gct tct gga atc cca gcc cct aaa atg acc tgg atg aaa gat     1809
 Cys Ile Ala Ser Gly Ile Pro Ala Pro Lys Met Thr Trp Met Lys Asp
             455                 460                 465

 ggc cgg ccc ctt cca cag acg gat caa gtg caa act cta gga gga gga     1857
 Gly Arg Pro Leu Pro Gln Thr Asp Gln Val Gln Thr Leu Gly Gly Gly
         470                 475                 480

 gag gtt ctt cga att tct act gct cag gtg gag gat aca gga aga tat     1905
 Glu Val Leu Arg Ile Ser Thr Ala Gln Val Glu Asp Thr Gly Arg Tyr
     485                 490                 495

 aca tgt ctg gca tcc agt cct gca gga gat gat gat aag gaa tat cta     1953
 Thr Cys Leu Ala Ser Ser Pro Ala Gly Asp Asp Asp Lys Glu Tyr Leu
 500                 505                 510                 515

 gtg aga gtg cat gta cct cct aat att gct gga act gat gag ccc cgg     2001
 Val Arg Val His Val Pro Pro Asn Ile Ala Gly Thr Asp Glu Pro Arg
                 520                 525                 530

 gat atc act gtg tta cgg aac aga caa gtg aca ttg gaa tgc aag tca     2049
 Asp Ile Thr Val Leu Arg Asn Arg Gln Val Thr Leu Glu Cys Lys Ser
             535                 540                 545

 gat gca gtg ccc cca cct gta att act tgg ctc aga aat gga gaa cgg     2097
 Asp Ala Val Pro Pro Pro Val Ile Thr Trp Leu Arg Asn Gly Glu Arg
         550                 555                 560

 tta cag gca aca cct cga gtg cga atc cta tct gga ggg aga tac ttg     2145
 Leu Gln Ala Thr Pro Arg Val Arg Ile Leu Ser Gly Gly Arg Tyr Leu
     565                 570                 575

 caa atc aac aat gct gac cta ggt gat aca gcc aat tat acc tgt gtt     2193
 Gln Ile Asn Asn Ala Asp Leu Gly Asp Thr Ala Asn Tyr Thr Cys Val
 580                 585                 590                 595

 gcc agc aac att gca gga aag act aca aga gaa ttt att ctc act gta     2241
 Ala Ser Asn Ile Ala Gly Lys Thr Thr Arg Glu Phe Ile Leu Thr Val
                 600                 605                 610

 aat gtt cct cca aac ata aag ggg ggc ccc cag agc ctt gta att ctt     2289
 Asn Val Pro Pro Asn Ile Lys Gly Gly Pro Gln Ser Leu Val Ile Leu
             615                 620                 625

 tta aat aag tca act gta ttg gaa tgc atc gct gaa ggt gtc cca act     2337
 Leu Asn Lys Ser Thr Val Leu Glu Cys Ile Ala Glu Gly Val Pro Thr
         630                 635                 640

 cca agg ata aca tgg aga aag gat gga gct gtt cta gct ggg aat cat     2385
 Pro Arg Ile Thr Trp Arg Lys Asp Gly Ala Val Leu Ala Gly Asn His
     645                 650                 655

 gca aga tat tcc atc ttg gaa aat gga ttc ctt cat att caa tca gca     2433
 Ala Arg Tyr Ser Ile Leu Glu Asn Gly Phe Leu His Ile Gln Ser Ala
 660                 665                 670                 675

 cat gtc act gac act gga cgg tat ttg tgt atg gcc acc aat gct gct     2481
 His Val Thr Asp Thr Gly Arg Tyr Leu Cys Met Ala Thr Asn Ala Ala
                 680                 685                 690

 gga aca gat cgc agg cga ata gat tta cag gtc cat gtt cct cca tct     2529
 Gly Thr Asp Arg Arg Arg Ile Asp Leu Gln Val His Val Pro Pro Ser
             695                 700                 705

 att gct ccg ggt cct acc aac atg act gta ata gta aat gtt caa act     2577
 Ile Ala Pro Gly Pro Thr Asn Met Thr Val Ile Val Asn Val Gln Thr
         710                 715                 720

 act ctg gct tgt gag gct act ggg ata cca aaa cca tca atc aat tgg     2625
 Thr Leu Ala Cys Glu Ala Thr Gly Ile Pro Lys Pro Ser Ile Asn Trp
     725                 730                 735

 aga aaa aat ggg cat ctt ctt aat gtg gat caa aat cag aac tca tac     2673
 Arg Lys Asn Gly His Leu Leu Asn Val Asp Gln Asn Gln Asn Ser Tyr
 740                 745                 750                 755

 agg ctc ctt tct tca ggt tca cta gta att att tcc cct tct gtg gat     2721
 Arg Leu Leu Ser Ser Gly Ser Leu Val Ile Ile Ser Pro Ser Val Asp
                 760                 765                 770

 gac act gca acc tat gaa tgt act gtg aca aac ggt gct gga gat gat     2769
 Asp Thr Ala Thr Tyr Glu Cys Thr Val Thr Asn Gly Ala Gly Asp Asp
             775                 780                 785

 aaa aga act gtg gat ctc act gtc caa gtt cca cct tcc ata gct gat     2817
 Lys Arg Thr Val Asp Leu Thr Val Gln Val Pro Pro Ser Ile Ala Asp
         790                 795                 800

 gag cct aca gat ttc cta gta acc aaa cat gcc cca gca gta att acc     2865
 Glu Pro Thr Asp Phe Leu Val Thr Lys His Ala Pro Ala Val Ile Thr
     805                 810                 815

 tgc act gct tcg gga gtt cca ttt ccc tca att cac tgg acc aaa aat     2913
 Cys Thr Ala Ser Gly Val Pro Phe Pro Ser Ile His Trp Thr Lys Asn
 820                 825                 830                 835

 ggt ata aga ctg ctt ccc agg gga gat ggc tat aga att ctg tcc tca     2961
 Gly Ile Arg Leu Leu Pro Arg Gly Asp Gly Tyr Arg Ile Leu Ser Ser
                 840                 845                 850

 gga gca att gaa ata ctt gcc acc caa tta aac cat gct gga aga tac     3009
 Gly Ala Ile Glu Ile Leu Ala Thr Gln Leu Asn His Ala Gly Arg Tyr
             855                 860                 865

 act tgt gtc gct agg aat gcg gct ggc tct gca cat cga cac gtg acc     3057
 Thr Cys Val Ala Arg Asn Ala Ala Gly Ser Ala His Arg His Val Thr
         870                 875                 880

 ctt cat gtt cat gag cct cca gtc att cag ccc caa cca agt gaa cta     3105
 Leu His Val His Glu Pro Pro Val Ile Gln Pro Gln Pro Ser Glu Leu
     885                 890                 895

 cac gtc att ctg aac aat cct att tta tta cca tgt gaa gca aca ggg     3153
 His Val Ile Leu Asn Asn Pro Ile Leu Leu Pro Cys Glu Ala Thr Gly
 900                 905                 910                 915

 aca ccc agt cct ttc att act tgg caa aaa gaa ggc atc aat gtt aac     3201
 Thr Pro Ser Pro Phe Ile Thr Trp Gln Lys Glu Gly Ile Asn Val Asn
                 920                 925                 930

 act tca ggc aga aac cat gca gtt ctt cct agt ggc ggc tta cag atc     3249
 Thr Ser Gly Arg Asn His Ala Val Leu Pro Ser Gly Gly Leu Gln Ile
             935                 940                 945

 tcc aga gct gtc cga gag gat gct ggc act tac atg tgt gtg gcc cag     3297
 Ser Arg Ala Val Arg Glu Asp Ala Gly Thr Tyr Met Cys Val Ala Gln
         950                 955                 960

 aac ccg gct ggt aca gcc ttg ggc aaa atc aag tta aat gtc caa gtt     3345
 Asn Pro Ala Gly Thr Ala Leu Gly Lys Ile Lys Leu Asn Val Gln Val
     965                 970                 975

 cct cca gtc att agc cct cat cta aag gaa tat gtt att gct gtg gac     3393
 Pro Pro Val Ile Ser Pro His Leu Lys Glu Tyr Val Ile Ala Val Asp
 980                 985                 990                 995

 aag ccc atc acg tta tcc tgt gaa gca gat ggc ctc cct ccg cct gac     3441
 Lys Pro Ile Thr Leu Ser Cys Glu Ala Asp Gly Leu Pro Pro Pro Asp
                1000                1005                1010

 att aca tgg cat aaa gat ggg cgt gca att gtg gaa tct atc cgc cag     3489
 Ile Thr Trp His Lys Asp Gly Arg Ala Ile Val Glu Ser Ile Arg Gln
            1015                1020                1025

 cgc gtc ctc agc tct ggc tct ctg caa ata aca ttt gtc cag cct ggt     3537
 Arg Val Leu Ser Ser Gly Ser Leu Gln Ile Thr Phe Val Gln Pro Gly
        1030                1035                1040

 gat gct ggc cat tac acg tgc atg gca gcc aat gta gca gga tca agc     3585
 Asp Ala Gly His Tyr Thr Cys Met Ala Ala Asn Val Ala Gly Ser Ser
    1045                1050                1055

 agc aca agc acc aag ctc acc gtc cat gta cca ccc agg atc aga agt     3633
 Ser Thr Ser Thr Lys Leu Thr Val His Val Pro Pro Arg Ile Arg Ser
1060                1065                1070                1075

 aca gaa gga cac tac acg gtc aat gag aat tca caa gcc att ctt cca     3681
 Thr Glu Gly His Tyr Thr Val Asn Glu Asn Ser Gln Ala Ile Leu Pro
                1080                1085                1090

 tgc gta gct gat gga atc ccc aca cca gca att aac tgg aaa aaa gac     3729
 Cys Val Ala Asp Gly Ile Pro Thr Pro Ala Ile Asn Trp Lys Lys Asp
            1095                1100                1105

 aat gtt ctt tta gct aac ttg tta gga aaa tac act gct gaa cca tat     3777
 Asn Val Leu Leu Ala Asn Leu Leu Gly Lys Tyr Thr Ala Glu Pro Tyr
        1110                1115                1120

 gga gaa ctc att tta gaa aat gtt gtg ctg gag gat tct ggc ttc tat     3825
 Gly Glu Leu Ile Leu Glu Asn Val Val Leu Glu Asp Ser Gly Phe Tyr
    1125                1130                1135

 acc tgt gtt gct aac aat gct gca ggt gaa gat aca cac act gtc agc     3873
 Thr Cys Val Ala Asn Asn Ala Ala Gly Glu Asp Thr His Thr Val Ser
1140                1145                1150                1155

 ctg act gtg cat gtt ctc ccc act ttt act gaa ctt cct gga gac gtg     3921
 Leu Thr Val His Val Leu Pro Thr Phe Thr Glu Leu Pro Gly Asp Val
                1160                1165                1170

 tca tta aat aaa gga gaa cag cta cga tta agc tgt aaa gct act ggt     3969
 Ser Leu Asn Lys Gly Glu Gln Leu Arg Leu Ser Cys Lys Ala Thr Gly
            1175                1180                1185

 att cca ttg ccc aaa tta aca tgg acc ttc aat aac aat att att cca     4017
 Ile Pro Leu Pro Lys Leu Thr Trp Thr Phe Asn Asn Asn Ile Ile Pro
        1190                1195                1200

 gcc cac ttt gac agt gtg aat gga cac agt gaa ctt gtt att gaa aga     4065
 Ala His Phe Asp Ser Val Asn Gly His Ser Glu Leu Val Ile Glu Arg
    1205                1210                1215

 gtg tca aaa gag gat tca ggt act tat gtg tgc acc gca gag aac agc     4113
 Val Ser Lys Glu Asp Ser Gly Thr Tyr Val Cys Thr Ala Glu Asn Ser
1220                1225                1230                1235

 gtt ggc ttt gtg aag gca att gga ttt gtg tat gtg aaa gaa cct cca     4161
 Val Gly Phe Val Lys Ala Ile Gly Phe Val Tyr Val Lys Glu Pro Pro
                1240                1245                1250

 gtc ttc aaa ggt gat tat cct tct cac tgg att gaa cca ctt ggt ggg     4209
 Val Phe Lys Gly Asp Tyr Pro Ser His Trp Ile Glu Pro Leu Gly Gly
            1255                1260                1265

 aat gca atc ctg aat tgt gag gtg aaa gga gac ccc acc cca acc atc     4257
 Asn Ala Ile Leu Asn Cys Glu Val Lys Gly Asp Pro Thr Pro Thr Ile
        1270                1275                1280

 cag tgg aac aga aag gga gtg gat att gaa att agc cac aga atc cgg     4305
 Gln Trp Asn Arg Lys Gly Val Asp Ile Glu Ile Ser His Arg Ile Arg
    1285                1290                1295

 caa ctg ggc aat ggc tcc ctg gcc atc tat ggc act gtt aat gaa gat     4353
 Gln Leu Gly Asn Gly Ser Leu Ala Ile Tyr Gly Thr Val Asn Glu Asp
1300                1305                1310                1315

 gcc ggt gac tat aca tgt gta gct acc aat gaa gct ggg gtg gtg gag     4401
 Ala Gly Asp Tyr Thr Cys Val Ala Thr Asn Glu Ala Gly Val Val Glu
                1320                1325                1330

 cgc agc atg agt ctg act ctg caa agt cct cct att atc act ctt gag     4449
 Arg Ser Met Ser Leu Thr Leu Gln Ser Pro Pro Ile Ile Thr Leu Glu
            1335                1340                1345

 cca gtg gaa act gtt att aat gct ggt ggc aaa atc ata ttg aat tgt     4497
 Pro Val Glu Thr Val Ile Asn Ala Gly Gly Lys Ile Ile Leu Asn Cys
        1350                1355                1360

 cag gca act gga gag cct caa cca acc att aca tgg tcc cgt caa ggg     4545
 Gln Ala Thr Gly Glu Pro Gln Pro Thr Ile Thr Trp Ser Arg Gln Gly
    1365                1370                1375

 cac tct att tcc tgg gat gac cgg gtt aac gtg ttg tcc aac aac tca     4593
 His Ser Ile Ser Trp Asp Asp Arg Val Asn Val Leu Ser Asn Asn Ser
1380                1385                1390                1395

 tta tat att gct gat gct cag aaa gaa gat acc tct gaa ttt gaa tgt     4641
 Leu Tyr Ile Ala Asp Ala Gln Lys Glu Asp Thr Ser Glu Phe Glu Cys
                1400                1405                1410

 gtt gct cga aac tta atg ggt tct gtc ctt gtc aga gtg cca gtc ata     4689
 Val Ala Arg Asn Leu Met Gly Ser Val Leu Val Arg Val Pro Val Ile
            1415                1420                1425

 gtc cag gtt cat ggt gga ttt tcc cag tgg tct gca tgg aga gcc tgc     4737
 Val Gln Val His Gly Gly Phe Ser Gln Trp Ser Ala Trp Arg Ala Cys
        1430                1435                1440

 agt gtc acc tgt gga aaa ggc atc caa aag agg agt cgt ctg tgc aac     4785
 Ser Val Thr Cys Gly Lys Gly Ile Gln Lys Arg Ser Arg Leu Cys Asn
    1445                1450                1455

 cag ccc ctt cca gcc aat ggt ggg aag ccc tgc caa ggt tca gat ttg     4833
 Gln Pro Leu Pro Ala Asn Gly Gly Lys Pro Cys Gln Gly Ser Asp Leu
1460                1465                1470                1475

 gaa atg cga aac tgt caa aat aag cct tgt cca gtg gat ggt agc tgg     4881
 Glu Met Arg Asn Cys Gln Asn Lys Pro Cys Pro Val Asp Gly Ser Trp
                1480                1485                1490

 tcg gaa tgg agt ctt tgg gaa gaa tgc aca agg agc tgt gga cgc ggc     4929
 Ser Glu Trp Ser Leu Trp Glu Glu Cys Thr Arg Ser Cys Gly Arg Gly
            1495                1500                1505

 aac caa acc agg acc agg act tgc aat aat cca tca gtt cag cat ggt     4977
 Asn Gln Thr Arg Thr Arg Thr Cys Asn Asn Pro Ser Val Gln His Gly
        1510                1515                1520

 ggg cgg cca tgt gaa ggg aat gct gtg gaa ata att atg tgc aac att     5025
 Gly Arg Pro Cys Glu Gly Asn Ala Val Glu Ile Ile Met Cys Asn Ile
    1525                1530                1535

 agg cct tgc cca gtt cat gga gca tgg agc gct tgg cag cct tgg gga     5073
 Arg Pro Cys Pro Val His Gly Ala Trp Ser Ala Trp Gln Pro Trp Gly
1540                1545                1550                1555

 aca tgc agc gaa agt tgt ggg aaa ggt act cag aca aga gca aga ctt     5121
 Thr Cys Ser Glu Ser Cys Gly Lys Gly Thr Gln Thr Arg Ala Arg Leu
                1560                1565                1570

 tgt aat aac cca cca cca gcg ttt ggt ggg tcc tac tgt gat gga gca     5169
 Cys Asn Asn Pro Pro Pro Ala Phe Gly Gly Ser Tyr Cys Asp Gly Ala
            1575                1580                1585

 gaa aca cag atg caa gtt tgc aat gaa aga aat tgt cca gtt cat ggc     5217
 Glu Thr Gln Met Gln Val Cys Asn Glu Arg Asn Cys Pro Val His Gly
        1590                1595                1600

 aag tgg gcg act tgg gcc agt tgg agt gcc tgt tct gtg tca tgt gga     5265
 Lys Trp Ala Thr Trp Ala Ser Trp Ser Ala Cys Ser Val Ser Cys Gly
    1605                1610                1615

 gga ggt gcc aga cag aga aca agg ggc tgc tcc gac cct gtg ccc cag     5313
 Gly Gly Ala Arg Gln Arg Thr Arg Gly Cys Ser Asp Pro Val Pro Gln
1620                1625                1630                1635

 tat gga gga agg aaa tgc gaa ggg agt gat gtc cag agt gat ttt tgc     5361
 Tyr Gly Gly Arg Lys Cys Glu Gly Ser Asp Val Gln Ser Asp Phe Cys
                1640                1645                1650

 aac agt gac cct tgc cca acc cat ggt aac tgg agt cct tgg agt ggc     5409
 Asn Ser Asp Pro Cys Pro Thr His Gly Asn Trp Ser Pro Trp Ser Gly
            1655                1660                1665

 tgg gga aca tgc agc cgg acg tgt aac gga ggg cag atg cgg cgg tac     5457
 Trp Gly Thr Cys Ser Arg Thr Cys Asn Gly Gly Gln Met Arg Arg Tyr
        1670                1675                1680

 cgc aca tgt gat aac cct cct ccc tcc aat ggg gga aga gct tgt ggg     5505
 Arg Thr Cys Asp Asn Pro Pro Pro Ser Asn Gly Gly Arg Ala Cys Gly
    1685                1690                1695

 gga cca gac tcc cag atc cag agg tgc aac act gac atg tgt cct gtg     5553
 Gly Pro Asp Ser Gln Ile Gln Arg Cys Asn Thr Asp Met Cys Pro Val
1700                1705                1710                1715

 gat gga agt tgg gga agc tgg cat agt tgg agc cag tgc tct gcc tcc     5601
 Asp Gly Ser Trp Gly Ser Trp His Ser Trp Ser Gln Cys Ser Ala Ser
                1720                1725                1730

 tgt gga gga ggt gaa aag act cgg aag cgg ctg tgc gac cat cct gtg     5649
 Cys Gly Gly Gly Glu Lys Thr Arg Lys Arg Leu Cys Asp His Pro Val
            1735                1740                1745

 cca gtt aaa ggt ggc cgt ccc tgt ccc gga gac act act cag gtg acc     5697
 Pro Val Lys Gly Gly Arg Pro Cys Pro Gly Asp Thr Thr Gln Val Thr
        1750                1755                1760

 agg tgc aat gta caa gca tgt cca ggt ggg ccc cag cga gcc aga gga     5745
 Arg Cys Asn Val Gln Ala Cys Pro Gly Gly Pro Gln Arg Ala Arg Gly
    1765                1770                1775

 agt gtt att gga aat att aat gat gtt gaa ttt gga att gct ttc ctt     5793
 Ser Val Ile Gly Asn Ile Asn Asp Val Glu Phe Gly Ile Ala Phe Leu
1780                1785                1790                1795

 aat gcc aca ata act gat agc cct aac tct gat act aga ata ata cgt     5841
 Asn Ala Thr Ile Thr Asp Ser Pro Asn Ser Asp Thr Arg Ile Ile Arg
                1800                1805                1810

 gcc aaa att acc aat gta cct cgt agt ctt ggt tca gca atg aga aag     5889
 Ala Lys Ile Thr Asn Val Pro Arg Ser Leu Gly Ser Ala Met Arg Lys
            1815                1820                1825

 ata gtt tct att cta aat ccc att tat tgg aca aca gca aag gaa ata     5937
 Ile Val Ser Ile Leu Asn Pro Ile Tyr Trp Thr Thr Ala Lys Glu Ile
        1830                1835                1840

 gga gaa gca gtc aat ggc ttt acc ctc acc aat gca gtc ttc aaa aga     5985
 Gly Glu Ala Val Asn Gly Phe Thr Leu Thr Asn Ala Val Phe Lys Arg
    1845                1850                1855

 gaa act caa gtg gaa ttt gca act gga gaa atc ttg cag atg agt cat     6033
 Glu Thr Gln Val Glu Phe Ala Thr Gly Glu Ile Leu Gln Met Ser His
1860                1865                1870                1875

 att gcc cgg ggc ttg gat tcc gat ggt tct ttg ctg cta gat atc gtt     6081
 Ile Ala Arg Gly Leu Asp Ser Asp Gly Ser Leu Leu Leu Asp Ile Val
                1880                1885                1890

 gtg agt ggc tat gtc cta cag ctt cag tca cct gct gaa gtc act gta     6129
 Val Ser Gly Tyr Val Leu Gln Leu Gln Ser Pro Ala Glu Val Thr Val
            1895                1900                1905

 aag gat tac aca gag gac tac att caa aca ggt cct ggg cag ctg tac     6177
 Lys Asp Tyr Thr Glu Asp Tyr Ile Gln Thr Gly Pro Gly Gln Leu Tyr
        1910                1915                1920

 gcc tac tca acc cgg ctg ttc acc att gat ggc atc agc atc cca tac     6225
 Ala Tyr Ser Thr Arg Leu Phe Thr Ile Asp Gly Ile Ser Ile Pro Tyr
    1925                1930                1935

 aca tgg aac cac acc gtt ttc tat gat cag gca cag gga aga atg cct     6273
 Thr Trp Asn His Thr Val Phe Tyr Asp Gln Ala Gln Gly Arg Met Pro
1940                1945                1950                1955

 ttc ttg gtt gaa aca ctt cat gca tcc tct gtg gaa tct gac tat aac     6321
 Phe Leu Val Glu Thr Leu His Ala Ser Ser Val Glu Ser Asp Tyr Asn
                1960                1965                1970

 cag ata gaa gag aca ctg ggt ttt aaa att cat gct tca ata tcc aaa     6369
 Gln Ile Glu Glu Thr Leu Gly Phe Lys Ile His Ala Ser Ile Ser Lys
            1975                1980                1985

 gga gat cgc agt aat cag tgc ccc tcc ggg ttt acc tta gac tca gtt     6417
 Gly Asp Arg Ser Asn Gln Cys Pro Ser Gly Phe Thr Leu Asp Ser Val
        1990                1995                2000

 gga cct ttt tgt gct gat gag gat gaa tgt gca gca ggg aat ccc tgc     6465
 Gly Pro Phe Cys Ala Asp Glu Asp Glu Cys Ala Ala Gly Asn Pro Cys
    2005                2010                2015

 tcc cat agc tgc cac aat gcc atg ggg act tac tac tgc tcc tgc cct     6513
 Ser His Ser Cys His Asn Ala Met Gly Thr Tyr Tyr Cys Ser Cys Pro
2020                2025                2030                2035

 aaa ggc ctc acc ata gct gca gat gga aga act tgt caa gat att gat     6561
 Lys Gly Leu Thr Ile Ala Ala Asp Gly Arg Thr Cys Gln Asp Ile Asp
                2040                2045                2050

 gag tgt gct ttg ggt agg cat acc tgc cac gct ggt cag gac tgt gac     6609
 Glu Cys Ala Leu Gly Arg His Thr Cys His Ala Gly Gln Asp Cys Asp
            2055                2060                2065

 aat acg att gga tct tat cgc tgt gtg gtc cgt tgt gga agt ggc ttt     6657
 Asn Thr Ile Gly Ser Tyr Arg Cys Val Val Arg Cys Gly Ser Gly Phe
        2070                2075                2080

 cga aga acc tct gat ggg ctg agt tgt caa gat att aat gaa tgt caa     6705
 Arg Arg Thr Ser Asp Gly Leu Ser Cys Gln Asp Ile Asn Glu Cys Gln
    2085                2090                2095

 gaa tcc agc ccc tgt cac cag cgc tgt ttc aat gcc ata gga agt ttc     6753
 Glu Ser Ser Pro Cys His Gln Arg Cys Phe Asn Ala Ile Gly Ser Phe
2100                2105                2110                2115

 cat tgt gga tgt gaa cct ggg tat cag ctc aaa ggc aga aaa tgc atg     6801
 His Cys Gly Cys Glu Pro Gly Tyr Gln Leu Lys Gly Arg Lys Cys Met
                2120                2125                2130

 gat gtg aac gag tgt aga caa aat gta tgc aga cca gat cag cac tgt     6849
 Asp Val Asn Glu Cys Arg Gln Asn Val Cys Arg Pro Asp Gln His Cys
            2135                2140                2145

 aag aac acc cgt ggt ggc tat aag tgc att gat ctt tgt cca aat gga     6897
 Lys Asn Thr Arg Gly Gly Tyr Lys Cys Ile Asp Leu Cys Pro Asn Gly
        2150                2155                2160

 atg acc aag gca gaa aat gga acc tgt att gat att gat gaa tgt aaa     6945
 Met Thr Lys Ala Glu Asn Gly Thr Cys Ile Asp Ile Asp Glu Cys Lys
    2165                2170                2175

 gat ggg acc cat cag tgc aga tat aac cag ata tgt gag aat aca aga     6993
 Asp Gly Thr His Gln Cys Arg Tyr Asn Gln Ile Cys Glu Asn Thr Arg
2180                2185                2190                2195

 ggc agc tat cgt tgt gta tgc cca aga ggt tat cgg tct caa gga gtt     7041
 Gly Ser Tyr Arg Cys Val Cys Pro Arg Gly Tyr Arg Ser Gln Gly Val
                2200                2205                2210

 gga aga ccc tgc atg gac att aat gaa tgt gaa caa gtg cct aaa cct     7089
 Gly Arg Pro Cys Met Asp Ile Asn Glu Cys Glu Gln Val Pro Lys Pro
            2215                2220                2225

 tgt gca cat cag tgc tcc aac acc ccc ggc agc ttc aag tgt atc tgt     7137
 Cys Ala His Gln Cys Ser Asn Thr Pro Gly Ser Phe Lys Cys Ile Cys
        2230                2235                2240

 cca cca gga caa cat tta tta ggg gac ggg aaa tct tgc gct gga ttg     7185
 Pro Pro Gly Gln His Leu Leu Gly Asp Gly Lys Ser Cys Ala Gly Leu
    2245                2250                2255

 gag agg ctg cca aat tat ggc act caa tac agt agc tat aac ctt gca     7233
 Glu Arg Leu Pro Asn Tyr Gly Thr Gln Tyr Ser Ser Tyr Asn Leu Ala
2260                2265                2270                2275

 cgg ttc tcc cct gtg aga aac aac tat caa cct caa cag cat tac aga     7281
 Arg Phe Ser Pro Val Arg Asn Asn Tyr Gln Pro Gln Gln His Tyr Arg
                2280                2285                2290

 cag tac tca cat ctc tac agc tcc tac tca gag tat aga aac agc aga     7329
 Gln Tyr Ser His Leu Tyr Ser Ser Tyr Ser Glu Tyr Arg Asn Ser Arg
            2295                2300                2305

 aca tct ctc tcc agg act aga agg act att agg aaa act tgc cct gaa     7377
 Thr Ser Leu Ser Arg Thr Arg Arg Thr Ile Arg Lys Thr Cys Pro Glu
        2310                2315                2320

 ggc tct gag gca agc cat gac aca tgt gta gat att gat gaa tgt gaa     7425
 Gly Ser Glu Ala Ser His Asp Thr Cys Val Asp Ile Asp Glu Cys Glu
    2325                2330                2335

 aat aca gat gcc tgc cag cat gag tgt aag aat acc ttt gga agt tat     7473
 Asn Thr Asp Ala Cys Gln His Glu Cys Lys Asn Thr Phe Gly Ser Tyr
2340                2345                2350                2355

 cag tgc atc tgc cca cct ggc tat caa ctc aca cac aat gga aag aca     7521
 Gln Cys Ile Cys Pro Pro Gly Tyr Gln Leu Thr His Asn Gly Lys Thr
                2360                2365                2370

 tgc caa gat atc gat gaa tgt ctg gag cag aat gtg cac tgt gga ccc     7569
 Cys Gln Asp Ile Asp Glu Cys Leu Glu Gln Asn Val His Cys Gly Pro
            2375                2380                2385

 aat cgc atg tgc ttc aac atg aga gga agc tac cag tgc atc gat aca     7617
 Asn Arg Met Cys Phe Asn Met Arg Gly Ser Tyr Gln Cys Ile Asp Thr
        2390                2395                2400

 ccc tgt cca ccc aac tac caa cgg gat cct gtt tca ggg ttc tgc ctc     7665
 Pro Cys Pro Pro Asn Tyr Gln Arg Asp Pro Val Ser Gly Phe Cys Leu
    2405                2410                2415

 aag aac tgt cca ccc aat gat ttg gaa tgt gcc ttg agc cca tat gcc     7713
 Lys Asn Cys Pro Pro Asn Asp Leu Glu Cys Ala Leu Ser Pro Tyr Ala
2420                2425                2430                2435

 ttg gaa tac aaa ctc gtc tcc ctc cca ttt gga ata gcc acc aat caa     7761
 Leu Glu Tyr Lys Leu Val Ser Leu Pro Phe Gly Ile Ala Thr Asn Gln
                2440                2445                2450

 gat tta atc cgg ctg gtt gca tac aca cag gat gga gtg atg cat ccc     7809
 Asp Leu Ile Arg Leu Val Ala Tyr Thr Gln Asp Gly Val Met His Pro
            2455                2460                2465

 agg aca act ttc ctc atg gta gat gag gaa cag act gtt cct ttt gcc     7857
 Arg Thr Thr Phe Leu Met Val Asp Glu Glu Gln Thr Val Pro Phe Ala
        2470                2475                2480

 ttg agg gat gaa aac ctg aaa gga gtg gtg tat aca aca cga cca cta     7905
 Leu Arg Asp Glu Asn Leu Lys Gly Val Val Tyr Thr Thr Arg Pro Leu
    2485                2490                2495

 cga gaa gca gag acc tac cgc atg agg gtc cga gcc tca tcc tac agt     7953
 Arg Glu Ala Glu Thr Tyr Arg Met Arg Val Arg Ala Ser Ser Tyr Ser
2500                2505                2510                2515

 gcc aat ggg acc att gaa tat cag acc aca ttc ata gtt tat ata gct     8001
 Ala Asn Gly Thr Ile Glu Tyr Gln Thr Thr Phe Ile Val Tyr Ile Ala
                2520                2525                2530

 gtg tcc gcc tat cca tac taa gg aactctccaa agcctattcc acatatttaa     8054
 Val Ser Ala Tyr Pro Tyr 
            2535

 accgcattaa tcatggcaat caagccccct tccagattac tgtctcttga acagttgcaa   8114

 tcttggcagc ttgaaaatgg tgctacactc tgttttgtgt gccttccttg gtacttctga   8174

 ggtattttca tgatcccacc atggtcatat cttgaagtat ggtctagaaa agtcccttat   8234

 tattttattt attacactgg agcagttact tcccaaagat tattctgaac atctaacagg   8294

 acatatcagt gatggtttac agtagtgtag tacctaagat cattttcctg aaagccaaac   8354

 caaacaacga aaaacaagaa caactaattc agaatcaaat agagtttttg agcatttgac   8414

 tatttttaga atcataaaat tagttactaa gtattttgat caaagcttat aaaataactt   8474

 acggagattt ttgtaagtat tgatacatta taataggact tgcctatttt catttttaag   8534

 aagaaaaacc cg                                                       8546




      <210> 37
      <211> 3190
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(2356)

      <400> 37
 tcagtgctgg cgcgtgaggc ggaggcgggc ggcggcggcg gcgcctgcgc ggtcggactc     60

 ggtcgacggt tcgcagggga ggaggcggcg ggaggcggag gaggcggcgg cg    atg     115
                                                              Met
                                                                1

 gag gtg aag cgg ctg aaa gtg acc gag ctg cgg tcg gag ctg cag cgg      163
 Glu Val Lys Arg Leu Lys Val Thr Glu Leu Arg Ser Glu Leu Gln Arg
               5                  10                  15

 cgg ggc ctg gac tcg cgc ggc ctc aag gtg gat ctg gcg cag cgg ctg      211
 Arg Gly Leu Asp Ser Arg Gly Leu Lys Val Asp Leu Ala Gln Arg Leu
          20                  25                  30

 cag gag gcg ctg gac gcc gag atg ctc gag gac gag gcc ggc ggc ggc      259
 Gln Glu Ala Leu Asp Ala Glu Met Leu Glu Asp Glu Ala Gly Gly Gly
      35                  40                  45

 ggg gcc ggg ccc ggc ggg gcc tgc aag gcg gag cct cgg cct gtg gcc      307
 Gly Ala Gly Pro Gly Gly Ala Cys Lys Ala Glu Pro Arg Pro Val Ala
  50                  55                  60                  65

 gcg tcg ggc ggc ggc ccg ggc ggg gac gag gag gag gac gaa gag gag      355
 Ala Ser Gly Gly Gly Pro Gly Gly Asp Glu Glu Glu Asp Glu Glu Glu
                  70                  75                  80

 gag gag gag gac gag gag gcg ctg ctt gag gac gag gac gag gag cca      403
 Glu Glu Glu Asp Glu Glu Ala Leu Leu Glu Asp Glu Asp Glu Glu Pro
              85                  90                  95

 ccc cct gct caa gcc ttg ggt cag gcc gcg cag ccg ccg ccg gag ccc      451
 Pro Pro Ala Gln Ala Leu Gly Gln Ala Ala Gln Pro Pro Pro Glu Pro
         100                 105                 110

 ccg gag gcg gca gcc atg gag gcc gcg gcc gag cca gat gct tcc gag      499
 Pro Glu Ala Ala Ala Met Glu Ala Ala Ala Glu Pro Asp Ala Ser Glu
     115                 120                 125

 aag ccg gcg gag gcc acg gcc ggg tca ggc ggg gta aat ggt ggc gaa      547
 Lys Pro Ala Glu Ala Thr Ala Gly Ser Gly Gly Val Asn Gly Gly Glu
 130                 135                 140                 145

 gag cag ggc ctc ggc aag agg gag gaa gac gaa ccc gag gag cgg agc      595
 Glu Gln Gly Leu Gly Lys Arg Glu Glu Asp Glu Pro Glu Glu Arg Ser
                 150                 155                 160

 ggg gac gag acg ccg gga tcc gag gtg ccg ggt gac aag gcc gcc gag      643
 Gly Asp Glu Thr Pro Gly Ser Glu Val Pro Gly Asp Lys Ala Ala Glu
             165                 170                 175

 gaa cag gga gat gac cag gat agt gaa aag tca aaa cca gca ggc tca      691
 Glu Gln Gly Asp Asp Gln Asp Ser Glu Lys Ser Lys Pro Ala Gly Ser
         180                 185                 190

 gat ggt gag cgg cgg ggg gta aag aga cag cgg gat gag aag gat gaa      739
 Asp Gly Glu Arg Arg Gly Val Lys Arg Gln Arg Asp Glu Lys Asp Glu
     195                 200                 205

 cat ggc cga gct tac tat gaa ttc cga gag gag gct tac cac agc cgc      787
 His Gly Arg Ala Tyr Tyr Glu Phe Arg Glu Glu Ala Tyr His Ser Arg
 210                 215                 220                 225

 tca aag tct cca ctg cct cct gaa gaa gag gca aaa gat gag gag gag      835
 Ser Lys Ser Pro Leu Pro Pro Glu Glu Glu Ala Lys Asp Glu Glu Glu
                 230                 235                 240

 gat caa act ctt gtg aac ctg gac acg tat acc tcg gat ctg cat ttt      883
 Asp Gln Thr Leu Val Asn Leu Asp Thr Tyr Thr Ser Asp Leu His Phe
             245                 250                 255

 caa gtg agc aaa gac cgc tat gga ggg cag cca ctt ttc tca gag aag      931
 Gln Val Ser Lys Asp Arg Tyr Gly Gly Gln Pro Leu Phe Ser Glu Lys
         260                 265                 270

 ttc ccc acc ctt tgg tct ggg gca agg agt act tac gga gtg aca aag      979
 Phe Pro Thr Leu Trp Ser Gly Ala Arg Ser Thr Tyr Gly Val Thr Lys
     275                 280                 285

 gga aaa gtc tgc ttt gag gca aag gta acc cag aat ctc cca atg aaa     1027
 Gly Lys Val Cys Phe Glu Ala Lys Val Thr Gln Asn Leu Pro Met Lys
 290                 295                 300                 305

 gaa ggc tgc aca gag gtc tct ctc ctt cga gtt ggg tgg tct gtt gat     1075
 Glu Gly Cys Thr Glu Val Ser Leu Leu Arg Val Gly Trp Ser Val Asp
                 310                 315                 320

 ttt tcc cgt cca cag ctt ggt gaa gat gaa ttc tct tac ggt ttc gat     1123
 Phe Ser Arg Pro Gln Leu Gly Glu Asp Glu Phe Ser Tyr Gly Phe Asp
             325                 330                 335

 gga cga gga ctc aag gca gaa aat gga caa ttt gag gaa ttt ggc cag     1171
 Gly Arg Gly Leu Lys Ala Glu Asn Gly Gln Phe Glu Glu Phe Gly Gln
         340                 345                 350

 act ttt ggg gag aat gat gtt att ggc tgc ttt gct aat ttt gag act     1219
 Thr Phe Gly Glu Asn Asp Val Ile Gly Cys Phe Ala Asn Phe Glu Thr
     355                 360                 365

 gaa gaa gta gaa ctt tcc ttc tcc aag aat gga gaa gac cta ggt gtg     1267
 Glu Glu Val Glu Leu Ser Phe Ser Lys Asn Gly Glu Asp Leu Gly Val
 370                 375                 380                 385

 gca ttc tgg atc agc aag gat tcc ctg gca gac cgg gcc ctt cta ccc     1315
 Ala Phe Trp Ile Ser Lys Asp Ser Leu Ala Asp Arg Ala Leu Leu Pro
                 390                 395                 400

 cat gtc ctc tgc aaa aat tgt gtt gta gaa tta aac ttc ggt cag aag     1363
 His Val Leu Cys Lys Asn Cys Val Val Glu Leu Asn Phe Gly Gln Lys
             405                 410                 415

 gag gag ccc ttc ttc cca cca cca gaa gag ttt gtg ttc att cat gct     1411
 Glu Glu Pro Phe Phe Pro Pro Pro Glu Glu Phe Val Phe Ile His Ala
         420                 425                 430

 gtg cct gtt gag gag cgt gta cgc act gca gtc cct ccc aag acc ata     1459
 Val Pro Val Glu Glu Arg Val Arg Thr Ala Val Pro Pro Lys Thr Ile
     435                 440                 445

 gag gaa tgt gag gtg att ctg atg gtg gga cta ccc gga tct gga aag     1507
 Glu Glu Cys Glu Val Ile Leu Met Val Gly Leu Pro Gly Ser Gly Lys
 450                 455                 460                 465

 acc cag tgg gca ctg aaa tat gca aaa gaa aac cct gag aaa aga tac     1555
 Thr Gln Trp Ala Leu Lys Tyr Ala Lys Glu Asn Pro Glu Lys Arg Tyr
                 470                 475                 480

 aat gtc ctg gga gct gag act gtg ctc aat caa atg agg atg aag ggt     1603
 Asn Val Leu Gly Ala Glu Thr Val Leu Asn Gln Met Arg Met Lys Gly
             485                 490                 495

 ctc gag gag cca gag atg gac ccc aaa agc cga gac ctt tta gtt cag     1651
 Leu Glu Glu Pro Glu Met Asp Pro Lys Ser Arg Asp Leu Leu Val Gln
         500                 505                 510

 caa gcc tcc cag tgc ctt agt aag ctg gtc cag att gct tcc cgg aca     1699
 Gln Ala Ser Gln Cys Leu Ser Lys Leu Val Gln Ile Ala Ser Arg Thr
     515                 520                 525

 aag agg aac ttt att ctt gat cag tgt aat gtg tac aat tct ggc caa     1747
 Lys Arg Asn Phe Ile Leu Asp Gln Cys Asn Val Tyr Asn Ser Gly Gln
 530                 535                 540                 545

 cgg cgg aag cta ttg ctg ttc aag acc ttc tct cgg aaa gtg gtg gtg     1795
 Arg Arg Lys Leu Leu Leu Phe Lys Thr Phe Ser Arg Lys Val Val Val
                 550                 555                 560

 gtt gtc cct aat gag gaa gat tgg aag aag agg ctg gag ttg agg aag     1843
 Val Val Pro Asn Glu Glu Asp Trp Lys Lys Arg Leu Glu Leu Arg Lys
             565                 570                 575

 gaa gta gag gga gat gat gtg cct gaa tct ata atg ctg gag atg aaa     1891
 Glu Val Glu Gly Asp Asp Val Pro Glu Ser Ile Met Leu Glu Met Lys
         580                 585                 590

 gcc aac ttc tct ttg cct gaa aaa tgc gac tat atg gat gag gtg aca     1939
 Ala Asn Phe Ser Leu Pro Glu Lys Cys Asp Tyr Met Asp Glu Val Thr
     595                 600                 605

 tat ggg gag ctg gag aag gag gaa gct cag ccc att gtc act aag tac     1987
 Tyr Gly Glu Leu Glu Lys Glu Glu Ala Gln Pro Ile Val Thr Lys Tyr
 610                 615                 620                 625

 aag gag gag gca agg aag ctt ctg ccc ccc tcc gag aag cgg aca aat     2035
 Lys Glu Glu Ala Arg Lys Leu Leu Pro Pro Ser Glu Lys Arg Thr Asn
                 630                 635                 640

 cgc cga aac aac cga aac aag cgt aac cgg cag aac cga agc cgg ggc     2083
 Arg Arg Asn Asn Arg Asn Lys Arg Asn Arg Gln Asn Arg Ser Arg Gly
             645                 650                 655

 caa ggc tat gtg ggc ggg cag cgc cga ggc tac gac aac cgg gcc tac     2131
 Gln Gly Tyr Val Gly Gly Gln Arg Arg Gly Tyr Asp Asn Arg Ala Tyr
         660                 665                 670

 ggg cag cag tac tgg ggg cag cct gga aac aga ggg ggt tac cgt aat     2179
 Gly Gln Gln Tyr Trp Gly Gln Pro Gly Asn Arg Gly Gly Tyr Arg Asn
     675                 680                 685

 ttc tat gat cga tac agg gga gac tat gat cga ttt tac ggg cga gat     2227
 Phe Tyr Asp Arg Tyr Arg Gly Asp Tyr Asp Arg Phe Tyr Gly Arg Asp
 690                 695                 700                 705

 tat gag tac aac aga tac aga gac tat tac aga caa tac aat cgg gat     2275
 Tyr Glu Tyr Asn Arg Tyr Arg Asp Tyr Tyr Arg Gln Tyr Asn Arg Asp
                 710                 715                 720

 tgg cag agt tac tac tac cac cac ccc cag gac aga gac cga tac tac     2323
 Trp Gln Ser Tyr Tyr Tyr His His Pro Gln Asp Arg Asp Arg Tyr Tyr
             725                 730                 735

 agg aat tac tac ggg tac caa ggg tat cgg tga agcccctg ccatggtcac     2374
 Arg Asn Tyr Tyr Gly Tyr Gln Gly Tyr Arg 
         740                 745

 ctgtcagcca tgaagctgaa tctctggggg tgccaggcac ccccgcaaaa cacaaccaag   2434

 gaaaacaggg gctgtcgggg tggggctgag ctgccgggga ggggtggtgg gggggggagg   2494

 gtggctccaa gcagggggtg ggggaaggcg gaaggggaaa ccaaacaaca aaactgtaca   2554

 tctgtgtcaa agttggtgca cacacgaata tggtcttata ctataagaac attacaaacc   2614

 tagttagcag attgtcatca cacaagcatt ggcgcagaag gcagcactta gggctgctgt   2674

 tctataacct acagccagaa cagggcaaag aaccggaaaa atgggacacc ttatggacca   2734

 tcctgacgca agctgggatg tgcagccaca gtacacggag actgaattca cggtggcgtg   2794

 ggaactgtca gcgcagacac acgcgaggca gcctcaacag gaggtacgga cacggaagag   2854

 gagtgacaca aggggaacct ggaaaccggg gagcccggaa caaagaaaac ggagtggcgc   2914

 ctaatacaaa cgcacggtgt gcaagacaat gaacaaaaca taaacgaggg cgcgccatca   2974

 aggcagacca cgaaaggggc ccgacaaatc agcacaccag actgggtgta ccagcggccc   3034

 cacgactagc caaaccacac cacacaccgg caaacaatca accagcagga aacacagagc   3094

 gacgagcacg acacacgtag cgatgacaga gaacacacag gcaccacgca aacagacaca   3154

 atgattagcg ccacatcatc gaacggacga agacag                             3190




      <210> 38
      <211> 4902
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4902)

      <400> 38
  atg gtt aaa aaa gag ata agc gtg cgt caa caa att cag gct ctt ctg      48
  Met Val Lys Lys Glu Ile Ser Val Arg Gln Gln Ile Gln Ala Leu Leu
    1               5                  10                  15

 tac aag aat ttt ctt aaa aaa tgg aga ata aaa aga gag gtg ctg gag       96
 Tyr Lys Asn Phe Leu Lys Lys Trp Arg Ile Lys Arg Glu Val Leu Glu
              20                  25                  30

 gaa tgg aca ata aca ttg ttt cta ggg cta tat ttg tgc atc ttt tcg      144
 Glu Trp Thr Ile Thr Leu Phe Leu Gly Leu Tyr Leu Cys Ile Phe Ser
          35                  40                  45

 gaa cac ttc aga gct acc cgt ttt cct gaa caa cct cct aaa gtc ctg      192
 Glu His Phe Arg Ala Thr Arg Phe Pro Glu Gln Pro Pro Lys Val Leu
      50                  55                  60

 gga agc gtg gat cag ttt aat gac tct ggc ctg gta gtg gca tat aca      240
 Gly Ser Val Asp Gln Phe Asn Asp Ser Gly Leu Val Val Ala Tyr Thr
  65                  70                  75                  80

 cca gtc agt aac ata aca caa agg ata atg aat aag atg gcc ttg gct      288
 Pro Val Ser Asn Ile Thr Gln Arg Ile Met Asn Lys Met Ala Leu Ala
                  85                  90                  95

 tcc ttt tac atg gta gga aga aca gtc att ggg aca cca gat gaa gag      336
 Ser Phe Tyr Met Val Gly Arg Thr Val Ile Gly Thr Pro Asp Glu Glu
             100                 105                 110

 acc atg gat ata gaa ctt cca aaa aaa tac cat gaa atg gtg gga gtt      384
 Thr Met Asp Ile Glu Leu Pro Lys Lys Tyr His Glu Met Val Gly Val
         115                 120                 125

 ata ttt agt gat act ttc tca tat cgc ctg aag ttt aat tgg gga tat      432
 Ile Phe Ser Asp Thr Phe Ser Tyr Arg Leu Lys Phe Asn Trp Gly Tyr
     130                 135                 140

 aga atc cca gtt ata aag gag cac tct gaa tac aca gcg cac tgt tgg      480
 Arg Ile Pro Val Ile Lys Glu His Ser Glu Tyr Thr Ala His Cys Trp
 145                 150                 155                 160

 gcc atg cat ggt gaa att ttt tgt tac ttg gca aag tac tgg cta aaa      528
 Ala Met His Gly Glu Ile Phe Cys Tyr Leu Ala Lys Tyr Trp Leu Lys
                 165                 170                 175

 ggg ttt gta gct ttt caa gct gca att aat gct gca att ata gaa gtc      576
 Gly Phe Val Ala Phe Gln Ala Ala Ile Asn Ala Ala Ile Ile Glu Val
             180                 185                 190

 aca aca aat cat tct gta atg gag gag ttg aca tca gtt att gga ata      624
 Thr Thr Asn His Ser Val Met Glu Glu Leu Thr Ser Val Ile Gly Ile
         195                 200                 205

 aat atg aag ata cca cct ttc att tct aag gga gaa att atg aat gaa      672
 Asn Met Lys Ile Pro Pro Phe Ile Ser Lys Gly Glu Ile Met Asn Glu
     210                 215                 220

 tgg ttt cat ttt act tgc tta gtt tct ttc tct tct ttt ata tac ttt      720
 Trp Phe His Phe Thr Cys Leu Val Ser Phe Ser Ser Phe Ile Tyr Phe
 225                 230                 235                 240

 gca tca tta aat gtt gca agg gaa aga gga aaa ttt aag aaa ctg atg      768
 Ala Ser Leu Asn Val Ala Arg Glu Arg Gly Lys Phe Lys Lys Leu Met
                 245                 250                 255

 aca gta atg ggt ctc cga gag tca gca ttc tgg ctc tcc tgg aga ttg      816
 Thr Val Met Gly Leu Arg Glu Ser Ala Phe Trp Leu Ser Trp Arg Leu
             260                 265                 270

 aca tac att tgc ttc atc ttc att atg tcc att ttt atg gct ctg gtc      864
 Thr Tyr Ile Cys Phe Ile Phe Ile Met Ser Ile Phe Met Ala Leu Val
         275                 280                 285

 ata aca tca atc tca att gta ttt cat act ggc ttc atg gtg ata ttc      912
 Ile Thr Ser Ile Ser Ile Val Phe His Thr Gly Phe Met Val Ile Phe
     290                 295                 300

 aca ctc tat agc tta tat ggc ctt tct ttg ata gca ttg gct ttc ctc      960
 Thr Leu Tyr Ser Leu Tyr Gly Leu Ser Leu Ile Ala Leu Ala Phe Leu
 305                 310                 315                 320

 atg agt gtt tta ata agg aaa cct atg ctc gct ggt ttg gct gga ttt     1008
 Met Ser Val Leu Ile Arg Lys Pro Met Leu Ala Gly Leu Ala Gly Phe
                 325                 330                 335

 ctc ttc act gta ttt tgg gga tgt ctg gga ttc act gtg tta tac aga     1056
 Leu Phe Thr Val Phe Trp Gly Cys Leu Gly Phe Thr Val Leu Tyr Arg
             340                 345                 350

 caa ctt cct tta tct ttg gga tgg gta tta agt ctt ctt agc cct ttt     1104
 Gln Leu Pro Leu Ser Leu Gly Trp Val Leu Ser Leu Leu Ser Pro Phe
         355                 360                 365

 gcc ttc act gct gga atg gcc cag gtt aca cac ctg gat aat tac tta     1152
 Ala Phe Thr Ala Gly Met Ala Gln Val Thr His Leu Asp Asn Tyr Leu
     370                 375                 380

 agt ggt gtt att ttt cct gat ccc tct ggg gat tca tac aaa atg ata     1200
 Ser Gly Val Ile Phe Pro Asp Pro Ser Gly Asp Ser Tyr Lys Met Ile
 385                 390                 395                 400

 gcc act ttt ttc att ttg gca ttt gat act ctt ttc tat ttg ata ttc     1248
 Ala Thr Phe Phe Ile Leu Ala Phe Asp Thr Leu Phe Tyr Leu Ile Phe
                 405                 410                 415

 aca tta tat ttt gag cga gtt tta cct gat aaa gat ggc cat ggg gat     1296
 Thr Leu Tyr Phe Glu Arg Val Leu Pro Asp Lys Asp Gly His Gly Asp
             420                 425                 430

 tct cca tta ttt ttc ctt aag tcc tca ttt tgg tcc aaa cat caa aat     1344
 Ser Pro Leu Phe Phe Leu Lys Ser Ser Phe Trp Ser Lys His Gln Asn
         435                 440                 445

 act cat cat gaa atc ttt gag aat gaa ata aat cct gag cat tcc tct     1392
 Thr His His Glu Ile Phe Glu Asn Glu Ile Asn Pro Glu His Ser Ser
     450                 455                 460

 gat gat tct ttt gaa ccg gtg tct cca gaa ttc cat gga aaa gaa gcc     1440
 Asp Asp Ser Phe Glu Pro Val Ser Pro Glu Phe His Gly Lys Glu Ala
 465                 470                 475                 480

 ata aga atc aga aat gtt ata aaa gaa tat aat gga aag act gga aaa     1488
 Ile Arg Ile Arg Asn Val Ile Lys Glu Tyr Asn Gly Lys Thr Gly Lys
                 485                 490                 495

 gta gaa gca ttg caa ggc ata ttt ttt gac ata tat gaa gga cag atc     1536
 Val Glu Ala Leu Gln Gly Ile Phe Phe Asp Ile Tyr Glu Gly Gln Ile
             500                 505                 510

 act gca ata ctt ggg cat aat gga gct ggt aaa tca aca ctg cta aac     1584
 Thr Ala Ile Leu Gly His Asn Gly Ala Gly Lys Ser Thr Leu Leu Asn
         515                 520                 525

 att ctt agt gga ttg tct gtt tct aca gaa gga tca gcc act att tat     1632
 Ile Leu Ser Gly Leu Ser Val Ser Thr Glu Gly Ser Ala Thr Ile Tyr
     530                 535                 540

 aat act caa ctc tct gaa ata act gac atg gaa gaa att aga aag aat     1680
 Asn Thr Gln Leu Ser Glu Ile Thr Asp Met Glu Glu Ile Arg Lys Asn
 545                 550                 555                 560

 att gga ttt tgt cca cag ttc aat ttt caa ttt gac ttc ctc act gtg     1728
 Ile Gly Phe Cys Pro Gln Phe Asn Phe Gln Phe Asp Phe Leu Thr Val
                 565                 570                 575

 aga gaa aac ctc agg gta ttt gct aaa ata aaa ggg att cag cca aag     1776
 Arg Glu Asn Leu Arg Val Phe Ala Lys Ile Lys Gly Ile Gln Pro Lys
             580                 585                 590

 gaa gtg gaa caa gag gta aaa aga att ata atg gaa tta gac atg caa     1824
 Glu Val Glu Gln Glu Val Lys Arg Ile Ile Met Glu Leu Asp Met Gln
         595                 600                 605

 agc att caa gac att att gct aaa aaa tta agt ggt ggg cag aag aga     1872
 Ser Ile Gln Asp Ile Ile Ala Lys Lys Leu Ser Gly Gly Gln Lys Arg
     610                 615                 620

 aaa cta aca cta ggg att gcc atc tta gga gat cct cag gtt ttg ctg     1920
 Lys Leu Thr Leu Gly Ile Ala Ile Leu Gly Asp Pro Gln Val Leu Leu
 625                 630                 635                 640

 cta gat gaa cca act gct gga ttg gat ccc ttt tca aga cac cga gtg     1968
 Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Phe Ser Arg His Arg Val
                 645                 650                 655

 tgg agc ctc ctg aag gag cat aaa gta gac cga ctt atc ctc ttc agt     2016
 Trp Ser Leu Leu Lys Glu His Lys Val Asp Arg Leu Ile Leu Phe Ser
             660                 665                 670

 acc caa ttc atg gat gag gct gac atc ttg gct gat agg aaa gta ttt     2064
 Thr Gln Phe Met Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Val Phe
         675                 680                 685

 ctg tct aat ggg aag ttg aaa tgt gca gga tca tct ttg ttt ctg aag     2112
 Leu Ser Asn Gly Lys Leu Lys Cys Ala Gly Ser Ser Leu Phe Leu Lys
     690                 695                 700

 cga aag tgg ggt att gga tat cat tta agt tta cac agg aat gaa atg     2160
 Arg Lys Trp Gly Ile Gly Tyr His Leu Ser Leu His Arg Asn Glu Met
 705                 710                 715                 720

 tgt gac aca gaa aaa atc aca tcc ctt att aag cag cac att cct gat     2208
 Cys Asp Thr Glu Lys Ile Thr Ser Leu Ile Lys Gln His Ile Pro Asp
                 725                 730                 735

 gcc aag tta aca aca gaa agt gaa gaa aaa ctt gta tat agt ttg cct     2256
 Ala Lys Leu Thr Thr Glu Ser Glu Glu Lys Leu Val Tyr Ser Leu Pro
             740                 745                 750

 ttg gaa aaa acg aac aaa ttt cca gat ctt tac agt gac ctt gat aag     2304
 Leu Glu Lys Thr Asn Lys Phe Pro Asp Leu Tyr Ser Asp Leu Asp Lys
         755                 760                 765

 tgt tct gac cag ggc ata agg aat tat gct gtt tca gtg aca tct ctg     2352
 Cys Ser Asp Gln Gly Ile Arg Asn Tyr Ala Val Ser Val Thr Ser Leu
     770                 775                 780

 aat gaa gta ttc ttg aac cta gaa gga aaa tca gca att gat gaa cca     2400
 Asn Glu Val Phe Leu Asn Leu Glu Gly Lys Ser Ala Ile Asp Glu Pro
 785                 790                 795                 800

 gat ttt gac att ggg aaa caa gag aaa ata cat gtg aca aga aat act     2448
 Asp Phe Asp Ile Gly Lys Gln Glu Lys Ile His Val Thr Arg Asn Thr
                 805                 810                 815

 gga gat gag tct gaa atg gaa cag gtt ctt tgt tct ctt cct gaa aca     2496
 Gly Asp Glu Ser Glu Met Glu Gln Val Leu Cys Ser Leu Pro Glu Thr
             820                 825                 830

 aga aag gct gtc agt agt gca gct ctc tgg aga cga caa atc tat gca     2544
 Arg Lys Ala Val Ser Ser Ala Ala Leu Trp Arg Arg Gln Ile Tyr Ala
         835                 840                 845

 gtg gca aca ctt cgc ttc tta aag tta agg cgt gaa agg aga gct ctt     2592
 Val Ala Thr Leu Arg Phe Leu Lys Leu Arg Arg Glu Arg Arg Ala Leu
     850                 855                 860

 ttg tgt ttg tta cta gta ctt gga att gct ttt atc ccc atc att cta     2640
 Leu Cys Leu Leu Leu Val Leu Gly Ile Ala Phe Ile Pro Ile Ile Leu
 865                 870                 875                 880

 gag aag ata atg tat aaa gta act cgt gaa act cat tgt tgg gag ttt     2688
 Glu Lys Ile Met Tyr Lys Val Thr Arg Glu Thr His Cys Trp Glu Phe
                 885                 890                 895

 tca ccc agt atg tat ttc ctt tct ctg gaa caa atc ccg aag acg cct     2736
 Ser Pro Ser Met Tyr Phe Leu Ser Leu Glu Gln Ile Pro Lys Thr Pro
             900                 905                 910

 ctt acc agc ctg tta atc gtt aat aat aca gga tca aat att gaa gac     2784
 Leu Thr Ser Leu Leu Ile Val Asn Asn Thr Gly Ser Asn Ile Glu Asp
         915                 920                 925

 ctc gtg cat tca ctg aag tgt cag gat ata gtt ttg gaa ata gat gac     2832
 Leu Val His Ser Leu Lys Cys Gln Asp Ile Val Leu Glu Ile Asp Asp
     930                 935                 940

 ttt aga aac aga aat ggc tca gat gat ccc tcc tac aat gga gcc atc     2880
 Phe Arg Asn Arg Asn Gly Ser Asp Asp Pro Ser Tyr Asn Gly Ala Ile
 945                 950                 955                 960

 ata gtg tct ggt gac cag aag gat tac aga ttt tct gtt gcg tgt aat     2928
 Ile Val Ser Gly Asp Gln Lys Asp Tyr Arg Phe Ser Val Ala Cys Asn
                 965                 970                 975

 acc aag aaa ttg aat tgt ttt cct gtt ctt atg gga att gtt agc aat     2976
 Thr Lys Lys Leu Asn Cys Phe Pro Val Leu Met Gly Ile Val Ser Asn
             980                 985                 990

 gcc ctt atg gga att ttt aac ttc acg gag ctt att caa acg gag agc     3024
 Ala Leu Met Gly Ile Phe Asn Phe Thr Glu Leu Ile Gln Thr Glu Ser
         995                1000                1005

 act tca ttt tct cgt gat gac ata gtg ctg gat ctt ggt ttt ata gat     3072
 Thr Ser Phe Ser Arg Asp Asp Ile Val Leu Asp Leu Gly Phe Ile Asp
    1010                1015                1020

 ggg tcc ata ttt ttg ttg ttg atc aca aac tgc gtt tct cct ttt atc     3120
 Gly Ser Ile Phe Leu Leu Leu Ile Thr Asn Cys Val Ser Pro Phe Ile
1025                1030                1035                1040

 ggc atg agc agc atc agc gat tat aaa aaa aat gtt caa tcc cag tta     3168
 Gly Met Ser Ser Ile Ser Asp Tyr Lys Lys Asn Val Gln Ser Gln Leu
                1045                1050                1055

 tgg att tca ggc ctc tgg cct tca gca tac tgg tgt gga cag gct ctg     3216
 Trp Ile Ser Gly Leu Trp Pro Ser Ala Tyr Trp Cys Gly Gln Ala Leu
            1060                1065                1070

 gtg gac att cca tta tac ttc ttg att ctc ttt tca ata cat tta att     3264
 Val Asp Ile Pro Leu Tyr Phe Leu Ile Leu Phe Ser Ile His Leu Ile
        1075                1080                1085

 tac tac ttc ata ttt ctg gga ttc cag ctt tca tgg gaa ctc atg ttt     3312
 Tyr Tyr Phe Ile Phe Leu Gly Phe Gln Leu Ser Trp Glu Leu Met Phe
    1090                1095                1100

 gtt ttg gtg gta tgc ata att ggt tgt gca gtt tct ctt ata ttc ctc     3360
 Val Leu Val Val Cys Ile Ile Gly Cys Ala Val Ser Leu Ile Phe Leu
1105                1110                1115                1120

 aca tat gtg ctt tca ttc atc ttt cgc aag tgg aga aaa aat aat ggc     3408
 Thr Tyr Val Leu Ser Phe Ile Phe Arg Lys Trp Arg Lys Asn Asn Gly
                1125                1130                1135

 ttt tgg tct ttt ggc ttt ttt att atc tta ata tgt gta tcc aca att     3456
 Phe Trp Ser Phe Gly Phe Phe Ile Ile Leu Ile Cys Val Ser Thr Ile
            1140                1145                1150

 atg gta tca act caa tat gaa aaa ctc aac tta att ttg tgc atg att     3504
 Met Val Ser Thr Gln Tyr Glu Lys Leu Asn Leu Ile Leu Cys Met Ile
        1155                1160                1165

 ttc ata cct tcc ttc act ttg ctg ggg tat gtc atg tta ttg atc cag     3552
 Phe Ile Pro Ser Phe Thr Leu Leu Gly Tyr Val Met Leu Leu Ile Gln
    1170                1175                1180

 ctc gac ttt atg aga aac ttg gac agt ctg gac aat aga ata aat gaa     3600
 Leu Asp Phe Met Arg Asn Leu Asp Ser Leu Asp Asn Arg Ile Asn Glu
1185                1190                1195                1200

 gtc aat aaa acc att ctt tta aca acc tta ata cca tac ctt cag agt     3648
 Val Asn Lys Thr Ile Leu Leu Thr Thr Leu Ile Pro Tyr Leu Gln Ser
                1205                1210                1215

 gtt att ttc ctt ttt gtc ata agg tgt ctg gaa atg aag tat gga aat     3696
 Val Ile Phe Leu Phe Val Ile Arg Cys Leu Glu Met Lys Tyr Gly Asn
            1220                1225                1230

 gaa ata atg aat aaa gac cca gtt ttc aga atc tct cca cgg agt aga     3744
 Glu Ile Met Asn Lys Asp Pro Val Phe Arg Ile Ser Pro Arg Ser Arg
        1235                1240                1245

 gaa act cat ccc aat ccg gaa gag ccc gaa gaa gaa gat gaa gat gtt     3792
 Glu Thr His Pro Asn Pro Glu Glu Pro Glu Glu Glu Asp Glu Asp Val
    1250                1255                1260

 caa gct gaa aga gtc caa gca gca aat gca ctc act gct cca aac ttg     3840
 Gln Ala Glu Arg Val Gln Ala Ala Asn Ala Leu Thr Ala Pro Asn Leu
1265                1270                1275                1280

 gag gag gaa cca gtc ata act gca agc tgt tta cac aag gaa tat tat     3888
 Glu Glu Glu Pro Val Ile Thr Ala Ser Cys Leu His Lys Glu Tyr Tyr
                1285                1290                1295

 gag aca aag aaa agt tgc ttt tca aca aga aag aag aaa ata gcc atc     3936
 Glu Thr Lys Lys Ser Cys Phe Ser Thr Arg Lys Lys Lys Ile Ala Ile
            1300                1305                1310

 aga aat gtt tcc ttt tgt gtt aaa aaa ggt gaa gtt ttg gga tta cta     3984
 Arg Asn Val Ser Phe Cys Val Lys Lys Gly Glu Val Leu Gly Leu Leu
        1315                1320                1325

 gga cac aat gga gct ggt aaa agt act tcc att aaa atg ata act ggg     4032
 Gly His Asn Gly Ala Gly Lys Ser Thr Ser Ile Lys Met Ile Thr Gly
    1330                1335                1340

 tgc aca aag cca act gca gga gtg gtg gtg tta caa ggc agc aga gca     4080
 Cys Thr Lys Pro Thr Ala Gly Val Val Val Leu Gln Gly Ser Arg Ala
1345                1350                1355                1360

 tca gta agg caa cag cat gac aac agc ctc aag ttc ttg ggg tac tgc     4128
 Ser Val Arg Gln Gln His Asp Asn Ser Leu Lys Phe Leu Gly Tyr Cys
                1365                1370                1375

 cct cag gag aac tca ctg tgg ccc aag ctt aca atg aaa gag cac ttg     4176
 Pro Gln Glu Asn Ser Leu Trp Pro Lys Leu Thr Met Lys Glu His Leu
            1380                1385                1390

 gag ttg tat gca gct gtg aaa gga ctg ggc aaa gaa gat gct gct ctc     4224
 Glu Leu Tyr Ala Ala Val Lys Gly Leu Gly Lys Glu Asp Ala Ala Leu
        1395                1400                1405

 agt att tca cga ttg gtg gaa gct ctt aag ctc cag gaa caa ctt aag     4272
 Ser Ile Ser Arg Leu Val Glu Ala Leu Lys Leu Gln Glu Gln Leu Lys
    1410                1415                1420

 gct cct gtg aaa act cta tca gag gga ata aag aga aag ctg tgc ttt     4320
 Ala Pro Val Lys Thr Leu Ser Glu Gly Ile Lys Arg Lys Leu Cys Phe
1425                1430                1435                1440

 gtg ctg agc atc ctg ggg aac cca tca gtg gtg ctt cta gat gag ccg     4368
 Val Leu Ser Ile Leu Gly Asn Pro Ser Val Val Leu Leu Asp Glu Pro
                1445                1450                1455

 ttc acc ggg atg gac ccc gag ggg cag cag caa atg tgg cag ata ctt     4416
 Phe Thr Gly Met Asp Pro Glu Gly Gln Gln Gln Met Trp Gln Ile Leu
            1460                1465                1470

 cag gct acc gtt aaa aac aag gag agg ggc acc ctc ttg acc acc cat     4464
 Gln Ala Thr Val Lys Asn Lys Glu Arg Gly Thr Leu Leu Thr Thr His
        1475                1480                1485

 tac atg tca gag gct gag gct gtg tgt gac cgt atg gcc atg atg gtg     4512
 Tyr Met Ser Glu Ala Glu Ala Val Cys Asp Arg Met Ala Met Met Val
    1490                1495                1500

 tca gga acg cta agg tgt att ggt tcc att caa cat ctg aaa aac aag     4560
 Ser Gly Thr Leu Arg Cys Ile Gly Ser Ile Gln His Leu Lys Asn Lys
1505                1510                1515                1520

 ttt ggt aga gat tat tta cta gaa ata aaa atg aaa gaa cct acc cag     4608
 Phe Gly Arg Asp Tyr Leu Leu Glu Ile Lys Met Lys Glu Pro Thr Gln
                1525                1530                1535

 gtg gaa gct ctc cac aca gag att ttg aag ctt ttc cca cag gct gct     4656
 Val Glu Ala Leu His Thr Glu Ile Leu Lys Leu Phe Pro Gln Ala Ala
            1540                1545                1550

 tgg cag gaa aga tat tcc tct tta atg gcg tat aag tta cct gtg gag     4704
 Trp Gln Glu Arg Tyr Ser Ser Leu Met Ala Tyr Lys Leu Pro Val Glu
        1555                1560                1565

 gat gtc cac cct cta tct cgg gcc ttt ttc aag tta gag gcg atg aaa     4752
 Asp Val His Pro Leu Ser Arg Ala Phe Phe Lys Leu Glu Ala Met Lys
    1570                1575                1580

 cag acc ttc aac ctg gag gaa tac agc ctc tct cag gct acc ttg gag     4800
 Gln Thr Phe Asn Leu Glu Glu Tyr Ser Leu Ser Gln Ala Thr Leu Glu
1585                1590                1595                1600

 cag gta ttc tta gaa ctc tgt aaa gag cag gag ctg gga aat gtt gat     4848
 Gln Val Phe Leu Glu Leu Cys Lys Glu Gln Glu Leu Gly Asn Val Asp
                1605                1610                1615

 gat aaa att gat aca aca gtt gaa tgg aaa ctt ctc cca cag gaa gac     4896
 Asp Lys Ile Asp Thr Thr Val Glu Trp Lys Leu Leu Pro Gln Glu Asp
            1620                1625                1630

 cct taa                                                             4902
 Pro 






      <210> 39
      <211> 2424
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (219)..(2369)

      <400> 39
 cgcgaattcc cgggtcgacg atttcgtcga gtccaaaatg gcggctctca ggctggcgcg     60

 ctccgtgctg ctggggcttt gaggtggtcg ccgggggtcc gggggaccct ttccccgccg    120

 cggaagccct agaggatgaa tcggggaccc tgctaaggtc tggcggcggg gctggagagc    180

 agtggcagca agggctgcgg tggcgtccac gcagcggg    atg tgc gag agt tac     233
                                              Met Cys Glu Ser Tyr
                                                1               5

 tcc agg tcg ttg ttg agg gtc tcg gtg gcg cag atc tgc cag gcg ctg      281
 Ser Arg Ser Leu Leu Arg Val Ser Val Ala Gln Ile Cys Gln Ala Leu
                  10                  15                  20

 ggc tgg gac tcg gtg cag ctc agc gcc tgc cac ctc ctc acg gac gtg      329
 Gly Trp Asp Ser Val Gln Leu Ser Ala Cys His Leu Leu Thr Asp Val
              25                  30                  35

 ctg cag cgc tat ctg cag cag ctg ggc cgg ggc tgc cat cgg tac tct      377
 Leu Gln Arg Tyr Leu Gln Gln Leu Gly Arg Gly Cys His Arg Tyr Ser
          40                  45                  50

 gag ctc tat ggc cga aca gac cca att ttg gat gat gtt ggt gaa gct      425
 Glu Leu Tyr Gly Arg Thr Asp Pro Ile Leu Asp Asp Val Gly Glu Ala
      55                  60                  65

 ttc cag ctg atg ggg gtt agt cta cat gaa cta gaa gac tat att cac      473
 Phe Gln Leu Met Gly Val Ser Leu His Glu Leu Glu Asp Tyr Ile His
  70                  75                  80                  85

 aac att gag cct gtc acc ttc cca cac caa att ccg tca ttt cct gtt      521
 Asn Ile Glu Pro Val Thr Phe Pro His Gln Ile Pro Ser Phe Pro Val
                  90                  95                 100

 agc aag aac aat gta ctt cag ttt cct caa cct gga agt aaa gat gca      569
 Ser Lys Asn Asn Val Leu Gln Phe Pro Gln Pro Gly Ser Lys Asp Ala
             105                 110                 115

 gag gaa aga aaa gaa tac att cct gat tac ctg cca ccc att gtg tct      617
 Glu Glu Arg Lys Glu Tyr Ile Pro Asp Tyr Leu Pro Pro Ile Val Ser
         120                 125                 130

 tct caa gaa gaa gaa gaa gaa gag cag gtg ccc act gat gga ggc aca      665
 Ser Gln Glu Glu Glu Glu Glu Glu Gln Val Pro Thr Asp Gly Gly Thr
     135                 140                 145

 tca gca gaa gcc atg cag gtt ccc ttg gaa gaa gat gat gaa ttg gag      713
 Ser Ala Glu Ala Met Gln Val Pro Leu Glu Glu Asp Asp Glu Leu Glu
 150                 155                 160                 165

 gag gaa gaa att att aat gat gag aat ttc ctg ggc aag aga cca ctg      761
 Glu Glu Glu Ile Ile Asn Asp Glu Asn Phe Leu Gly Lys Arg Pro Leu
                 170                 175                 180

 gat agt cct gaa gct gaa gaa ctg cca gcc atg aag cgg cct cgg cta      809
 Asp Ser Pro Glu Ala Glu Glu Leu Pro Ala Met Lys Arg Pro Arg Leu
             185                 190                 195

 tta agc act aaa ggg gac acg cta gat gtt gtg tta ttg gaa gct cga      857
 Leu Ser Thr Lys Gly Asp Thr Leu Asp Val Val Leu Leu Glu Ala Arg
         200                 205                 210

 gag cca ctc agc tca ata aat act caa aag atc cca cca atg ctt tct      905
 Glu Pro Leu Ser Ser Ile Asn Thr Gln Lys Ile Pro Pro Met Leu Ser
     215                 220                 225

 cca gtc cat gta cag gac agt aca gac ttg gca cct ccc tca ccc gag      953
 Pro Val His Val Gln Asp Ser Thr Asp Leu Ala Pro Pro Ser Pro Glu
 230                 235                 240                 245

 ccg cca atg ttg gct cca gtt gca aaa tca caa atg cca act gca aaa     1001
 Pro Pro Met Leu Ala Pro Val Ala Lys Ser Gln Met Pro Thr Ala Lys
                 250                 255                 260

 cca tta gaa aca aag tca ttt aca cct aaa aca aag act aaa act agc     1049
 Pro Leu Glu Thr Lys Ser Phe Thr Pro Lys Thr Lys Thr Lys Thr Ser
             265                 270                 275

 tct cca gga cag aag act aaa tca cct aaa acc gcc cag tca cca gca     1097
 Ser Pro Gly Gln Lys Thr Lys Ser Pro Lys Thr Ala Gln Ser Pro Ala
         280                 285                 290

 atg gtc gga agt cct att cga tca cca aaa act gta tcc aaa gaa aag     1145
 Met Val Gly Ser Pro Ile Arg Ser Pro Lys Thr Val Ser Lys Glu Lys
     295                 300                 305

 aaa tca cct gga cgt tcc aag agc ccc aag agt ccc aag agc ccc aag     1193
 Lys Ser Pro Gly Arg Ser Lys Ser Pro Lys Ser Pro Lys Ser Pro Lys
 310                 315                 320                 325

 gtc acg act cac att ccc caa aca cct gtg aga cct gaa acg ccc aac     1241
 Val Thr Thr His Ile Pro Gln Thr Pro Val Arg Pro Glu Thr Pro Asn
                 330                 335                 340

 agg act cct tca gct aca ctc agt gaa aaa atc agt aaa gag act atc     1289
 Arg Thr Pro Ser Ala Thr Leu Ser Glu Lys Ile Ser Lys Glu Thr Ile
             345                 350                 355

 cag gta aaa caa ata cag aca ccc cct gat gct ggg aaa ctg aac agt     1337
 Gln Val Lys Gln Ile Gln Thr Pro Pro Asp Ala Gly Lys Leu Asn Ser
         360                 365                 370

 gag aat cag ccg aaa aag gct gtg gta gca gat aaa acg att gag gcc     1385
 Glu Asn Gln Pro Lys Lys Ala Val Val Ala Asp Lys Thr Ile Glu Ala
     375                 380                 385

 tct atc gat gct gtg att gca cga gcc tgt gct gag cga gag cca gat     1433
 Ser Ile Asp Ala Val Ile Ala Arg Ala Cys Ala Glu Arg Glu Pro Asp
 390                 395                 400                 405

 cct ttc gaa ttt tct tct gga tcg gaa tct gaa gga gac att ttt act     1481
 Pro Phe Glu Phe Ser Ser Gly Ser Glu Ser Glu Gly Asp Ile Phe Thr
                 410                 415                 420

 agc cct aag aga att tca ggc ccg gag tgt act act ccc aaa gct tcc     1529
 Ser Pro Lys Arg Ile Ser Gly Pro Glu Cys Thr Thr Pro Lys Ala Ser
             425                 430                 435

 act tcc gcg aac aat ttc aca aag tca gga tcc act cct ctg cct ctt     1577
 Thr Ser Ala Asn Asn Phe Thr Lys Ser Gly Ser Thr Pro Leu Pro Leu
         440                 445                 450

 tcc ggt gga acc tca agt tcc gat aac tca tgg aca atg gat gcc tcc     1625
 Ser Gly Gly Thr Ser Ser Ser Asp Asn Ser Trp Thr Met Asp Ala Ser
     455                 460                 465

 att gat gag gtt gta cgt aaa gca aaa ctg gga aca cct tca aat atg     1673
 Ile Asp Glu Val Val Arg Lys Ala Lys Leu Gly Thr Pro Ser Asn Met
 470                 475                 480                 485

 ccc ccc aac ttt cct tat atc tct tct ccg tca gtg tct cct ccc act     1721
 Pro Pro Asn Phe Pro Tyr Ile Ser Ser Pro Ser Val Ser Pro Pro Thr
                 490                 495                 500

 ccc gaa cct ctc cac aag gtg tat gag gag aaa acc aag ctg cct tcc     1769
 Pro Glu Pro Leu His Lys Val Tyr Glu Glu Lys Thr Lys Leu Pro Ser
             505                 510                 515

 tcc gtg gag gta aag aag aag ttg aaa aag gaa cta aag act aaa atg     1817
 Ser Val Glu Val Lys Lys Lys Leu Lys Lys Glu Leu Lys Thr Lys Met
         520                 525                 530

 aaa aag aaa gaa aag cag aga gat agg gag agg gaa aaa gac aag aac     1865
 Lys Lys Lys Glu Lys Gln Arg Asp Arg Glu Arg Glu Lys Asp Lys Asn
     535                 540                 545

 aag gac aaa agt aag gag aag gat aaa gtg aaa gag aaa gag aaa gac     1913
 Lys Asp Lys Ser Lys Glu Lys Asp Lys Val Lys Glu Lys Glu Lys Asp
 550                 555                 560                 565

 aag gaa act ggc agg gaa aca aag tat ccc tgg aag gaa ttt ctt aaa     1961
 Lys Glu Thr Gly Arg Glu Thr Lys Tyr Pro Trp Lys Glu Phe Leu Lys
                 570                 575                 580

 gag gaa gag gca gat ccc tac aag ttt aaa atc aaa gaa ttt gaa gat     2009
 Glu Glu Glu Ala Asp Pro Tyr Lys Phe Lys Ile Lys Glu Phe Glu Asp
             585                 590                 595

 gtt gat ccc aaa gtg aaa ttg aaa gat gga ctt gtg agg aag gag aaa     2057
 Val Asp Pro Lys Val Lys Leu Lys Asp Gly Leu Val Arg Lys Glu Lys
         600                 605                 610

 gag aag cat aaa gat aag aag aaa gat aga gag aaa ggc aag aaa gat     2105
 Glu Lys His Lys Asp Lys Lys Lys Asp Arg Glu Lys Gly Lys Lys Asp
     615                 620                 625

 aaa gat aag aga gag aaa gaa aaa gtg aaa gat aaa ggc aga gaa gat     2153
 Lys Asp Lys Arg Glu Lys Glu Lys Val Lys Asp Lys Gly Arg Glu Asp
 630                 635                 640                 645

 aag atg aaa gcc cca gca ccc cca ctg gtg ttg ccc cca aaa gag ttg     2201
 Lys Met Lys Ala Pro Ala Pro Pro Leu Val Leu Pro Pro Lys Glu Leu
                 650                 655                 660

 gcc ctg ccc ttg ttc agc cct gcc aca gcc tcc agg gtc cca gcc atg     2249
 Ala Leu Pro Leu Phe Ser Pro Ala Thr Ala Ser Arg Val Pro Ala Met
             665                 670                 675

 ctg cca tct ttg ttg cca gtg ctt ccg gaa aaa ctg ttt gag gag aaa     2297
 Leu Pro Ser Leu Leu Pro Val Leu Pro Glu Lys Leu Phe Glu Glu Lys
         680                 685                 690

 gag aag ccg aag gag aaa gaa aag aaa aag gac aaa aag gag aaa aaa     2345
 Glu Lys Pro Lys Glu Lys Glu Lys Lys Lys Asp Lys Lys Glu Lys Lys
     695                 700                 705

 aaa aaa aaa ggg cgg ccg ctc tag agtatccctc gaggggccca agcttacgcg    2399
 Lys Lys Lys Gly Arg Pro Leu 
 710                 715

 tacccagctt tcttgtacaa agtgg                                         2424




      <210> 40
      <211> 2186
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (708)..(1346)

      <400> 40
 ttttggaagc cgtacgcttt gaagtaccgt tccggaattc ccgggtcgac ccacgcgtcc     60

 gcaaaatact tctctctcca ggtaattaaa caattctgat tgagaaacct gtgtaggaat    120

 gagccagtct tcctcctatc taggtaattt acttaaaatt cactgtttgg actcacaaat    180

 cataatgtaa gatatgagag taaatgtcat atatttgtat ttcacaagta ttttctaaca    240

 ggtgtttttg gaaaacatta tagggagtat tgctgaacat tcttcgctgt ggaattttca    300

 gtattagaaa gtgttgctaa attatcaaag ctgtttggat taaattatca gacaaatttt    360

 ttcagacctg tgtaatgaag tgattagatg tttagatcaa aggcaataat cttgaaatgt    420

 ttaattatat atataagttc ccagttacca ttgttgagca gtgagaagct tcaatcaaac    480

 aactcattta ttttcaaatc attgtttctg ttccagatca cagcctgcat cagactatgt    540

 tggtgtacgt cttttacaca gttcccattc cagtcatcac tgcttacatg actacatgaa    600

 aacatcaaaa agacaattgt gattctgctt attatctgtt ttatttttct tcttagcaaa    660

 ctttttctaa tacaattttt cttttgacta gacacaaaca gcacagc  atg att ctt     716
                                                      Met Ile Leu
                                                        1

 gtt ccc atg aac aca cct gga gta aaa ata ata agg cct ttg tca gtt      764
 Val Pro Met Asn Thr Pro Gly Val Lys Ile Ile Arg Pro Leu Ser Val
       5                  10                  15

 ttt ggc tac aca gat aat ttt cat gga gga cat ttt gag atc cat ttt      812
 Phe Gly Tyr Thr Asp Asn Phe His Gly Gly His Phe Glu Ile His Phe
  20                  25                  30                  35

 aat caa gtg cga gtt cct gcc aca aat cta ata cta ggt gaa ggt agg      860
 Asn Gln Val Arg Val Pro Ala Thr Asn Leu Ile Leu Gly Glu Gly Arg
                  40                  45                  50

 gga ttt gaa att tcc caa ggc cgc ctt gga cct ggc aga atc cac cac      908
 Gly Phe Glu Ile Ser Gln Gly Arg Leu Gly Pro Gly Arg Ile His His
              55                  60                  65

 tgt atg aga aca gta ggt ttg gcg gaa cgc gct ttg cag atc atg tgt      956
 Cys Met Arg Thr Val Gly Leu Ala Glu Arg Ala Leu Gln Ile Met Cys
          70                  75                  80

 gag cgg gca aca caa agg ata gct ttc aag aag aag ttg tat gca cat     1004
 Glu Arg Ala Thr Gln Arg Ile Ala Phe Lys Lys Lys Leu Tyr Ala His
      85                  90                  95

 gag gtt gtg gct cac tgg att gct gaa agc cgc att gcc att gag aag     1052
 Glu Val Val Ala His Trp Ile Ala Glu Ser Arg Ile Ala Ile Glu Lys
 100                 105                 110                 115

 atc cgc ttg ttg act ctg aaa gct gct cac agc atg gac act ctg ggc     1100
 Ile Arg Leu Leu Thr Leu Lys Ala Ala His Ser Met Asp Thr Leu Gly
                 120                 125                 130

 agt gct ggc gct aag aaa gag att gca atg atc aaa gtg gct gcc cca     1148
 Ser Ala Gly Ala Lys Lys Glu Ile Ala Met Ile Lys Val Ala Ala Pro
             135                 140                 145

 cgg gct gtc agc aaa atc gtt gac tgg gcc atc cag gtg tgc gga ggt     1196
 Arg Ala Val Ser Lys Ile Val Asp Trp Ala Ile Gln Val Cys Gly Gly
         150                 155                 160

 gct ggt gtt tcc cag gat tac cct ctg gct aac atg tat gct ata acc     1244
 Ala Gly Val Ser Gln Asp Tyr Pro Leu Ala Asn Met Tyr Ala Ile Thr
     165                 170                 175

 cga gtt ttg cgt tta gca gat gga cct gac gaa gtt cat ctt tca gca     1292
 Arg Val Leu Arg Leu Ala Asp Gly Pro Asp Glu Val His Leu Ser Ala
 180                 185                 190                 195

 atc gca aca atg gag ctg cgg gac caa gcc aaa aga ctg aca gcc aag     1340
 Ile Ala Thr Met Glu Leu Arg Asp Gln Ala Lys Arg Leu Thr Ala Lys
                 200                 205                 210

 ata taa ggagggtggc actgccacat cccactggca gaaactctcc tttatacaaa      1396
 Ile 


 cttcattggc tccaacattt gaatctcata tttttgtagc agtttgagca cagggttaat   1456

 tattcatttg tggtaaagat tatagcatct attttgatca gtgggtttta ttatttcaag   1516

 ggtcacacag ggttaagttc agtaagaaat gctgtagctg ttgtcattca atctagtgcc   1576

 tccttgaggc caggagttca ggaccagcct gggcaacata gcgagacccc cattgctaca   1636

 aaaaatttaa aaatgaaaca agtgtggtgg cacatgcttg tagtcctagc tacttgggag   1696

 gctgaggcag gaggattgct tgagtctagg agtttgaggt tacagtaagc tgtgatcgtg   1756

 acatggcctc cagcctgggt gaccgagtga gactgtttct aaaaataaaa aaaaaaaata   1816

 aatttcttct gaggtggggt ggaggtgggg agcaagaatt tgacctggct ctgatccctg   1876

 gtgtgttgtg tgggcctctt taacgtttgc cactgagcct taacctcact gtacttcact   1936

 gtacttcaca cgcattggtg ttaacatttt aatcttagaa gaccctgacc cactgagggt   1996

 ttgttgtgaa aattgctgaa gccacgtaaa agccccttga aatctgtaaa accccaagaa   2056

 agtactttat aaaaggtatc cttatttgaa gtggataaat cttgtaactc gaaaagttgt   2116

 gatttagaag acaggattgt ttttgaacat taggaattaa aggctatatc tggtccttaa   2176

 aaaaaaaaaa                                                          2186




      <210> 41
      <211> 2306
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(1807)

      <400> 41
 ctgcagggac agcacccggt aactgcgagt ggagcggagg acccgagcgg ctgaggagag     60

 aggaggcggc ggcttagctg ctacggggtc cggccggcgc cctcccgagg ggggctcagg    120

 aggaggaagg aggacccgtg cgaga  atg cct ctg ccc tgg agc ctt gcg ctc     172
                              Met Pro Leu Pro Trp Ser Leu Ala Leu
                                1               5

 ccg ctg ctg ctc tcc tgg gtg gca ggt ggt ttc ggg aac gcg gcc agt      220
 Pro Leu Leu Leu Ser Trp Val Ala Gly Gly Phe Gly Asn Ala Ala Ser
  10                  15                  20                  25

 gca agg cat cac ggg ttg tta gca tcg gca cgt cag cct ggg gtc tgt      268
 Ala Arg His His Gly Leu Leu Ala Ser Ala Arg Gln Pro Gly Val Cys
                  30                  35                  40

 cac tat gga act aaa ctg gcc tgc tgc tac ggc tgg aga aga aac agc      316
 His Tyr Gly Thr Lys Leu Ala Cys Cys Tyr Gly Trp Arg Arg Asn Ser
              45                  50                  55

 aag gga gtc tgt gaa gct aca tgc gaa cct gga tgt aag ttt ggt gag      364
 Lys Gly Val Cys Glu Ala Thr Cys Glu Pro Gly Cys Lys Phe Gly Glu
          60                  65                  70

 tgc gtg gga cca aac aaa tgc aga tgc ttt cca gga tac acc ggg aaa      412
 Cys Val Gly Pro Asn Lys Cys Arg Cys Phe Pro Gly Tyr Thr Gly Lys
      75                  80                  85

 acc tgc agt caa gat gtg aat gag tgt gga atg aaa ccc cgg cca tgc      460
 Thr Cys Ser Gln Asp Val Asn Glu Cys Gly Met Lys Pro Arg Pro Cys
  90                  95                 100                 105

 caa cac aga tgt gtg aat aca cac gga agc tac aag tgc ttt tgc ctc      508
 Gln His Arg Cys Val Asn Thr His Gly Ser Tyr Lys Cys Phe Cys Leu
                 110                 115                 120

 agt ggc cac atg ctc atg cca gat gct acg tgt gtg aac tct agg aca      556
 Ser Gly His Met Leu Met Pro Asp Ala Thr Cys Val Asn Ser Arg Thr
             125                 130                 135

 tgt gcc atg ata aac tgt cag tat agc tgt gaa gac aca gaa gaa ggg      604
 Cys Ala Met Ile Asn Cys Gln Tyr Ser Cys Glu Asp Thr Glu Glu Gly
         140                 145                 150

 cca cag tgc ctg tgt cca tcc tca gga ctc cgc ctg gcc cca aat gga      652
 Pro Gln Cys Leu Cys Pro Ser Ser Gly Leu Arg Leu Ala Pro Asn Gly
     155                 160                 165

 aga gac tgt cta gat att gat gaa tgt gcc tct ggt aaa gtc atc tgt      700
 Arg Asp Cys Leu Asp Ile Asp Glu Cys Ala Ser Gly Lys Val Ile Cys
 170                 175                 180                 185

 ccc tac aat cga aga tgt gtg aac aca ttt gga agc tac tac tgc aaa      748
 Pro Tyr Asn Arg Arg Cys Val Asn Thr Phe Gly Ser Tyr Tyr Cys Lys
                 190                 195                 200

 tgt cac att ggt ttc gaa ctg caa tat atc agt gga cga tat gac tgt      796
 Cys His Ile Gly Phe Glu Leu Gln Tyr Ile Ser Gly Arg Tyr Asp Cys
             205                 210                 215

 ata gat ata aat gaa tgt act atg gat agc cat acg tgc agc cac cat      844
 Ile Asp Ile Asn Glu Cys Thr Met Asp Ser His Thr Cys Ser His His
         220                 225                 230

 gcc aat tgc ttc aat acc caa ggg tcc ttc aag tgt aaa tgc aag cag      892
 Ala Asn Cys Phe Asn Thr Gln Gly Ser Phe Lys Cys Lys Cys Lys Gln
     235                 240                 245

 gga tat aaa ggc aat gga ctt cgg tgt tct gct atc cct gaa aat tct      940
 Gly Tyr Lys Gly Asn Gly Leu Arg Cys Ser Ala Ile Pro Glu Asn Ser
 250                 255                 260                 265

 gtg aag gaa gtc ctc aga gca cct ggt acc atc aaa gac aga atc aag      988
 Val Lys Glu Val Leu Arg Ala Pro Gly Thr Ile Lys Asp Arg Ile Lys
                 270                 275                 280

 aag ttg ctt gct cac aaa aac agc atg aaa aag aag gca aaa att aaa     1036
 Lys Leu Leu Ala His Lys Asn Ser Met Lys Lys Lys Ala Lys Ile Lys
             285                 290                 295

 aat gtt acc cca gaa ccc acc agg act cct acc cct aag gtg aac ttg     1084
 Asn Val Thr Pro Glu Pro Thr Arg Thr Pro Thr Pro Lys Val Asn Leu
         300                 305                 310

 cag ccc ttc aac tat gaa gag ata gtt tcc aga ggc ggg aac tct cat     1132
 Gln Pro Phe Asn Tyr Glu Glu Ile Val Ser Arg Gly Gly Asn Ser His
     315                 320                 325

 gga ggt aaa aaa ggg aat gaa gag aaa atg aaa gag ggg ctt gag gat     1180
 Gly Gly Lys Lys Gly Asn Glu Glu Lys Met Lys Glu Gly Leu Glu Asp
 330                 335                 340                 345

 gag aaa aga gaa gag aaa gcc ctg aag aat gac ata gag gag cga agc     1228
 Glu Lys Arg Glu Glu Lys Ala Leu Lys Asn Asp Ile Glu Glu Arg Ser
                 350                 355                 360

 ctg cga gga gat gtg ttt ttc cct aag gtg aat gaa gca ggt gaa ttc     1276
 Leu Arg Gly Asp Val Phe Phe Pro Lys Val Asn Glu Ala Gly Glu Phe
             365                 370                 375

 ggc ctg att ctg gtc caa agg aaa gcg cta act tcc aaa ctg gaa cat     1324
 Gly Leu Ile Leu Val Gln Arg Lys Ala Leu Thr Ser Lys Leu Glu His
         380                 385                 390

 aaa gat tta aat atc tcg gtt gac tgc agc ttc aat cat ggg atc tgt     1372
 Lys Asp Leu Asn Ile Ser Val Asp Cys Ser Phe Asn His Gly Ile Cys
     395                 400                 405

 gac tgg aaa cag gat aga gaa gat gat ttt gac tgg aat cct gct gat     1420
 Asp Trp Lys Gln Asp Arg Glu Asp Asp Phe Asp Trp Asn Pro Ala Asp
 410                 415                 420                 425

 cga gat aat gct att ggc ttc tat atg gca gtt ccg gcc ttg gca ggt     1468
 Arg Asp Asn Ala Ile Gly Phe Tyr Met Ala Val Pro Ala Leu Ala Gly
                 430                 435                 440

 cac aag aaa gac att ggc cga ttg aaa ctt ctc cta cct gac ctg caa     1516
 His Lys Lys Asp Ile Gly Arg Leu Lys Leu Leu Leu Pro Asp Leu Gln
             445                 450                 455

 ccc caa agc aac ttc tgt ttg ctc ttt gat tac cgg ctg gcc gga gac     1564
 Pro Gln Ser Asn Phe Cys Leu Leu Phe Asp Tyr Arg Leu Ala Gly Asp
         460                 465                 470

 aaa gtc ggg aaa ctt cga gtg ttt gtg aaa aac agt aac aat gcc ctg     1612
 Lys Val Gly Lys Leu Arg Val Phe Val Lys Asn Ser Asn Asn Ala Leu
     475                 480                 485

 gca tgg gag aag acc acg agt gag gat gaa aag tgg aag aca ggg aaa     1660
 Ala Trp Glu Lys Thr Thr Ser Glu Asp Glu Lys Trp Lys Thr Gly Lys
 490                 495                 500                 505

 att cag ttg tat caa gga act gat gct acc aaa agc atc att ttt gaa     1708
 Ile Gln Leu Tyr Gln Gly Thr Asp Ala Thr Lys Ser Ile Ile Phe Glu
                 510                 515                 520

 gca gaa cgt ggc aag ggc aaa acc ggc gaa atc gca gtg gat ggc gtc     1756
 Ala Glu Arg Gly Lys Gly Lys Thr Gly Glu Ile Ala Val Asp Gly Val
             525                 530                 535

 ttg ctt gtt tca ggc tta tgt cca gat agc ctt tta tct gtg gat gac     1804
 Leu Leu Val Ser Gly Leu Cys Pro Asp Ser Leu Leu Ser Val Asp Asp
         540                 545                 550

 tga atgt tactatcttt atatttgact ttgtatgtca gttccctggt ttttttgata     1861
 


 ttgsatcata ggacctctgg cattttaaaa ttactaagct gaaaaattgt aatgtaccaa   1921

 cagaaattat tattgtaaga tgcctttmtt gtataagata tgccaatatt tgctttaaat   1981

 atcatatcac tgtatcttct cagtcatttc tgaatctttc cacattatat tataaaatat   2041

 ggaaatgtca ggtttatctc ccctcctcag tatatctgat ttgtataagt aagttgatga   2101

 gcttctctct gcaacatttc tagaaaatag ahaaaaaagc acagagaaat gtttaactgt   2161

 ttgactctta tgatagtttt tggaaactat gacatcaaag atagactttt gcctaagtgg   2221

 cttagctggg tctttcatag ccaaacttgt atatttaaat tctttgtaat aataatatcc   2281

 aaatcatcaa aaaaaaaaaa aaaaa                                         2306




      <210> 42
      <211> 2082
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2082)

      <400> 42
  atg caa cag cca agt cac aaa ggc aca tta agc aaa gtg ggt gct gaa      48
  Met Gln Gln Pro Ser His Lys Gly Thr Leu Ser Lys Val Gly Ala Glu
    1               5                  10                  15

 aag cat cag gca gga ggc tgg aca ggc gag tca tgg ctg aaa ggc tta       96
 Lys His Gln Ala Gly Gly Trp Thr Gly Glu Ser Trp Leu Lys Gly Leu
              20                  25                  30

 gag gag gct aga gtt tct gag cta gga ttt gaa gaa gga gac tgc caa      144
 Glu Glu Ala Arg Val Ser Glu Leu Gly Phe Glu Glu Gly Asp Cys Gln
          35                  40                  45

 gga ttc gtg aaa acc acg tat tat aga caa aca gag gga atg agc aca      192
 Gly Phe Val Lys Thr Thr Tyr Tyr Arg Gln Thr Glu Gly Met Ser Thr
      50                  55                  60

 cag gct aga gca gca aag gaa act ttt ctg gta cat tct tac atc cag      240
 Gln Ala Arg Ala Ala Lys Glu Thr Phe Leu Val His Ser Tyr Ile Gln
  65                  70                  75                  80

 gcc act aat atc aga cta ggt aac aca gtc tta aca act ttt ctg gat      288
 Ala Thr Asn Ile Arg Leu Gly Asn Thr Val Leu Thr Thr Phe Leu Asp
                  85                  90                  95

 aat gaa gct aag att cag ggc aaa ctc tca tgc cag gag gtg ctg cac      336
 Asn Glu Ala Lys Ile Gln Gly Lys Leu Ser Cys Gln Glu Val Leu His
             100                 105                 110

 ctg tac tgt gac act tgc tct gta ccc atc tgt cgt gag tgc aca atg      384
 Leu Tyr Cys Asp Thr Cys Ser Val Pro Ile Cys Arg Glu Cys Thr Met
         115                 120                 125

 ggc cgg cat ggg ggc cac agc ttc atc tac ctc cag gag gca ctg cag      432
 Gly Arg His Gly Gly His Ser Phe Ile Tyr Leu Gln Glu Ala Leu Gln
     130                 135                 140

 gac tca cgg gca ctc acc atc cag ctg ctg gca gat gcc cag cag gga      480
 Asp Ser Arg Ala Leu Thr Ile Gln Leu Leu Ala Asp Ala Gln Gln Gly
 145                 150                 155                 160

 cga cag gca atc cag ctg agc atc gag cag gcc cag acg gtg gcg gaa      528
 Arg Gln Ala Ile Gln Leu Ser Ile Glu Gln Ala Gln Thr Val Ala Glu
                 165                 170                 175

 cag gtg gag atg aag gcg aag gtt gtg cag tcg gag gtc aaa gcc gtg      576
 Gln Val Glu Met Lys Ala Lys Val Val Gln Ser Glu Val Lys Ala Val
             180                 185                 190

 act gcg agg cat aag aaa gcc ctg gag gaa cgc gag tgt gag ctg ctg      624
 Thr Ala Arg His Lys Lys Ala Leu Glu Glu Arg Glu Cys Glu Leu Leu
         195                 200                 205

 tgg aag gta gaa aag atc cgc cag gtg aaa gcc aag tct ctg tac ctg      672
 Trp Lys Val Glu Lys Ile Arg Gln Val Lys Ala Lys Ser Leu Tyr Leu
     210                 215                 220

 cag gtg gag aag ctg cgg caa aac ctc aac aag ctt gag agc acc atc      720
 Gln Val Glu Lys Leu Arg Gln Asn Leu Asn Lys Leu Glu Ser Thr Ile
 225                 230                 235                 240

 agt gcc gtg cag cag gtc ctg gag gag ggt aga gcg cta gac atc cta      768
 Ser Ala Val Gln Gln Val Leu Glu Glu Gly Arg Ala Leu Asp Ile Leu
                 245                 250                 255

 ctg gcc cga gac cgg atg ctg gcc cag gtg cag gag ctg aag acc gtg      816
 Leu Ala Arg Asp Arg Met Leu Ala Gln Val Gln Glu Leu Lys Thr Val
             260                 265                 270

 cgg agc ctc ctg cag ccc cag gaa gac gac cga gtc atg ttc aca ccc      864
 Arg Ser Leu Leu Gln Pro Gln Glu Asp Asp Arg Val Met Phe Thr Pro
         275                 280                 285

 ccc gat cag gca ctg tac ctt gcc atc aag tct ttt ggc ttt gtt agc      912
 Pro Asp Gln Ala Leu Tyr Leu Ala Ile Lys Ser Phe Gly Phe Val Ser
     290                 295                 300

 agc ggg gcc ttt gcc cca ctc acc aag gcc aca ggc gat ggc ctc aag      960
 Ser Gly Ala Phe Ala Pro Leu Thr Lys Ala Thr Gly Asp Gly Leu Lys
 305                 310                 315                 320

 cgt gcc ctc cag ggt aag gtg gcc tcc ttc aca gtc att ggt tat gac     1008
 Arg Ala Leu Gln Gly Lys Val Ala Ser Phe Thr Val Ile Gly Tyr Asp
                 325                 330                 335

 cac gat ggt gag ccc cgc ctc tca gga ggc gac ctg atg tcg gct gtg     1056
 His Asp Gly Glu Pro Arg Leu Ser Gly Gly Asp Leu Met Ser Ala Val
             340                 345                 350

 gtc ctg ggc cct gat ggc aac ctg ttt ggt gca gag gtg agt gat cag     1104
 Val Leu Gly Pro Asp Gly Asn Leu Phe Gly Ala Glu Val Ser Asp Gln
         355                 360                 365

 cag aat ggg aca tac gtg gtg agt tac cga ccc cag ctg gag ggt gag     1152
 Gln Asn Gly Thr Tyr Val Val Ser Tyr Arg Pro Gln Leu Glu Gly Glu
     370                 375                 380

 cac ctg gta tct gtg aca ctg tgc aac cag cac att gag aac agc cct     1200
 His Leu Val Ser Val Thr Leu Cys Asn Gln His Ile Glu Asn Ser Pro
 385                 390                 395                 400

 ttc aag gtg gtg gtc aag tca ggc cgc agc tac gtg ggc att ggg ctc     1248
 Phe Lys Val Val Val Lys Ser Gly Arg Ser Tyr Val Gly Ile Gly Leu
                 405                 410                 415

 ccg ggc ctg agc ttc ggc agt gag ggt gac agc gat ggc aag ctc tgc     1296
 Pro Gly Leu Ser Phe Gly Ser Glu Gly Asp Ser Asp Gly Lys Leu Cys
             420                 425                 430

 cgc cct tgg ggt gtg agt gta gac aag gag ggc tac atc att gtc gcc     1344
 Arg Pro Trp Gly Val Ser Val Asp Lys Glu Gly Tyr Ile Ile Val Ala
         435                 440                 445

 gac cgc agc aac aac cgc atc cag gtg ttc aag ccc tgc ggc gcc ttc     1392
 Asp Arg Ser Asn Asn Arg Ile Gln Val Phe Lys Pro Cys Gly Ala Phe
     450                 455                 460

 cac cac aaa ttc ggc acc ctg ggc tcc cgg cct ggg cag ttc gac cga     1440
 His His Lys Phe Gly Thr Leu Gly Ser Arg Pro Gly Gln Phe Asp Arg
 465                 470                 475                 480

 cca gcc ggc gtg gcc tgt gac gcc tca cgc agg atc gtg gtg gct gac     1488
 Pro Ala Gly Val Ala Cys Asp Ala Ser Arg Arg Ile Val Val Ala Asp
                 485                 490                 495

 aag gac aat cat cgc atc cag atc ttc acg ttc gag ggc cag ttc ctc     1536
 Lys Asp Asn His Arg Ile Gln Ile Phe Thr Phe Glu Gly Gln Phe Leu
             500                 505                 510

 ctc aag ttt ggt gag aaa gga acc aag aat ggg cag ttc aac tac cct     1584
 Leu Lys Phe Gly Glu Lys Gly Thr Lys Asn Gly Gln Phe Asn Tyr Pro
         515                 520                 525

 tgg gat gtg gcg gtg aat tct gag ggc aag atc ctg gtc tca gac acg     1632
 Trp Asp Val Ala Val Asn Ser Glu Gly Lys Ile Leu Val Ser Asp Thr
     530                 535                 540

 agg aac cac cgg atc cag ctg ttt ggg cct gat ggt gtc ttc cta aac     1680
 Arg Asn His Arg Ile Gln Leu Phe Gly Pro Asp Gly Val Phe Leu Asn
 545                 550                 555                 560

 aag tat ggc ttc gag ggg gct ctc tgg aag cac ttt gac tcc cca cgg     1728
 Lys Tyr Gly Phe Glu Gly Ala Leu Trp Lys His Phe Asp Ser Pro Arg
                 565                 570                 575

 ggt gtg gcc ttc aac cat gag ggc cac ttg gtg gtc act gac ttc aac     1776
 Gly Val Ala Phe Asn His Glu Gly His Leu Val Val Thr Asp Phe Asn
             580                 585                 590

 aac cac cgg ctc ctg gtt att cac ccc gac tgc cag tct gca cgc ttt     1824
 Asn His Arg Leu Leu Val Ile His Pro Asp Cys Gln Ser Ala Arg Phe
         595                 600                 605

 ctg ggc tcg gag ggc aca ggc aat ggg cag ttc ctg cgc cca caa ggg     1872
 Leu Gly Ser Glu Gly Thr Gly Asn Gly Gln Phe Leu Arg Pro Gln Gly
     610                 615                 620

 gta gct gtg gac cag gaa ggg cgc atc att gtg gcg gat tcc agg aac     1920
 Val Ala Val Asp Gln Glu Gly Arg Ile Ile Val Ala Asp Ser Arg Asn
 625                 630                 635                 640

 cat cgg gta cag atg ttt gaa tcc aac ggc agc ttc ctg tgc aag ttt     1968
 His Arg Val Gln Met Phe Glu Ser Asn Gly Ser Phe Leu Cys Lys Phe
                 645                 650                 655

 ggt gct caa ggc agc ggc ttt ggg cag atg gac cgc cct tcc ggc atc     2016
 Gly Ala Gln Gly Ser Gly Phe Gly Gln Met Asp Arg Pro Ser Gly Ile
             660                 665                 670

 gcc atc acc ccc gac gga atg atc gtt gtg gtg gac ttt ggc aac aat     2064
 Ala Ile Thr Pro Asp Gly Met Ile Val Val Val Asp Phe Gly Asn Asn
         675                 680                 685

 cga atc ctc gtc ttc taa                                             2082
 Arg Ile Leu Val Phe 
     690





      <210> 43
      <211> 4470
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (425)..(3835)

      <400> 43
 cctagggtct gcaggagagg cggtggagcg ggcttgcctt cagggaaaag ggggctgcag     60

 gggcgcagct tcggcctgtg cgtgtgtctg gggtctgagg gcgaggctcc aggggcttgg    120

 tggcgtctga gcgcgtgtgg aggtccgggt ctctgcgtgt catcgtgcac gtgtcttcgc    180

 gcccactccg cagagccgca ggctgaggcc gggaagggtc gggggcgagg ccgcgtcgcc    240

 gcctccccga agccttttcc tgttgggggg gagggcccgc cagtgacggc cgggcctgtc    300

 acgtgggcct gacagctggg gagggggtgg ccggcgacaa tgtggtcccg aagcggccag    360

 cgccgggagc tgcagcgctg agacccccag cccgccccct cgggctcccg gccggggccc    420

 catc atg ttc tcc agg aag aaa cga gag ctc atg aaa acc cct tcc atc     469
      Met Phe Ser Arg Lys Lys Arg Glu Leu Met Lys Thr Pro Ser Ile
        1               5                  10                  15

 tcg aaa aag aac cgc gcg gga agc ccc agc ccg cag ccc tcg ggg gag      517
 Ser Lys Lys Asn Arg Ala Gly Ser Pro Ser Pro Gln Pro Ser Gly Glu
                  20                  25                  30

 ctg ccc agg aag gat ggg gct gac gcg gtg ttc ccc gga cca agc ctg      565
 Leu Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro Gly Pro Ser Leu
              35                  40                  45

 gag ccg ccc gct ggg tcc tcc ggc gtc aag gcc aca ggg acc ctc aag      613
 Glu Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Thr Gly Thr Leu Lys
          50                  55                  60

 cgg ccc acc agc ctg agc cgc cac gcc agc gcg gct ggc ttc ccc ctg      661
 Arg Pro Thr Ser Leu Ser Arg His Ala Ser Ala Ala Gly Phe Pro Leu
      65                  70                  75

 tcg ggt gct gcc tcc tgg aca ctg ggc cgg agc cac cgg agc cca ctg      709
 Ser Gly Ala Ala Ser Trp Thr Leu Gly Arg Ser His Arg Ser Pro Leu
  80                  85                  90                  95

 aca gcc gcc agc ccg ggc gag ctg ccc acc gag ggt gcc ggc ccg gac      757
 Thr Ala Ala Ser Pro Gly Glu Leu Pro Thr Glu Gly Ala Gly Pro Asp
                 100                 105                 110

 gtc gtc gag gac atc tcc cat ctg ctg gcg gac gtg gcc cgc ttc gct      805
 Val Val Glu Asp Ile Ser His Leu Leu Ala Asp Val Ala Arg Phe Ala
             115                 120                 125

 gag ggc ctt gag aaa ctt aag gag tgt gtg ttg cgt gac gac ctc ctt      853
 Glu Gly Leu Glu Lys Leu Lys Glu Cys Val Leu Arg Asp Asp Leu Leu
         130                 135                 140

 gag gcc cgc cgc ccg cgg gcc cac gag tgc ctg ggt gag gct ctg cgt      901
 Glu Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly Glu Ala Leu Arg
     145                 150                 155

 gtc atg cat cag atc atc tcc aag tac ccg ctg ctg aac acc gtg gag      949
 Val Met His Gln Ile Ile Ser Lys Tyr Pro Leu Leu Asn Thr Val Glu
 160                 165                 170                 175

 acg ctc acc gca gcc ggc acc ctc att gcc aag gtc aaa gcc ttc cat      997
 Thr Leu Thr Ala Ala Gly Thr Leu Ile Ala Lys Val Lys Ala Phe His
                 180                 185                 190

 tat gag agc aac aat gat ctg gag aaa cag gag ttc gag aag gcc ctg     1045
 Tyr Glu Ser Asn Asn Asp Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu
             195                 200                 205

 gag acg att gct gtg gcc ttc agt agc aca gtg tcc gag ttc ctc atg     1093
 Glu Thr Ile Ala Val Ala Phe Ser Ser Thr Val Ser Glu Phe Leu Met
         210                 215                 220

 ggt gaa gtg gac agc agc acc ctc cta gca gtg cct cct ggg gac tcg     1141
 Gly Glu Val Asp Ser Ser Thr Leu Leu Ala Val Pro Pro Gly Asp Ser
     225                 230                 235

 agc cag tcc atg gaa agc ctg tat gga ccg ggc agt gag ggc acg cct     1189
 Ser Gln Ser Met Glu Ser Leu Tyr Gly Pro Gly Ser Glu Gly Thr Pro
 240                 245                 250                 255

 ccc agc ctg gat gac tgt gac gcc ggc tgc ctg ccc gcc gag gag gtg     1237
 Pro Ser Leu Asp Asp Cys Asp Ala Gly Cys Leu Pro Ala Glu Glu Val
                 260                 265                 270

 gac gtg ctg cta cag cgc tgt gag ggg ggc gtg gat gcc gca ctg ctg     1285
 Asp Val Leu Leu Gln Arg Cys Glu Gly Gly Val Asp Ala Ala Leu Leu
             275                 280                 285

 tat gcc aag aac atg gcc aag tac atg aag gac ctc atc agc tac ctg     1333
 Tyr Ala Lys Asn Met Ala Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu
         290                 295                 300

 gag aag cgg acg acg ctg gag atg gag ttt gcc aag ggc ctg cag aag     1381
 Glu Lys Arg Thr Thr Leu Glu Met Glu Phe Ala Lys Gly Leu Gln Lys
     305                 310                 315

 atc gct cac aac tgc aga cag agc gtc atg cag gag ccc cac atg ccg     1429
 Ile Ala His Asn Cys Arg Gln Ser Val Met Gln Glu Pro His Met Pro
 320                 325                 330                 335

 ctc ctg tcc atc tac tcg ctg gcc ctg gag cag gac ctg gag ttc ggc     1477
 Leu Leu Ser Ile Tyr Ser Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly
                 340                 345                 350

 cac agc atg gtg cag gcg gtg ggc acc ttg cag acc cag acc ttc atg     1525
 His Ser Met Val Gln Ala Val Gly Thr Leu Gln Thr Gln Thr Phe Met
             355                 360                 365

 cag ccc ctg acc ctg cgg cgg ctt gaa cac gag aag cgc agg aag gag     1573
 Gln Pro Leu Thr Leu Arg Arg Leu Glu His Glu Lys Arg Arg Lys Glu
         370                 375                 380

 atc aag gag gcc tgg cac cgt gcc cag agg aag ctg caa gag gcg gag     1621
 Ile Lys Glu Ala Trp His Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu
     385                 390                 395

 tcc aac ctg cgc aag gcc aag cag ggt tac gtg cag cgc tgc gag gac     1669
 Ser Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp
 400                 405                 410                 415

 cac gac aag gct cgc ttc ctc gtg gcc aag gcg gag gag gag cag gct     1717
 His Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu Glu Glu Gln Ala
                 420                 425                 430

 ggc agc gcg ccg gga gca ggc ggc acg gcc acc aag acc ctg gac aag     1765
 Gly Ser Ala Pro Gly Ala Gly Gly Thr Ala Thr Lys Thr Leu Asp Lys
             435                 440                 445

 cgg cgg cgg ctg gag gag gag gcc aag aac aag gcg gag gaa gct atg     1813
 Arg Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala Glu Glu Ala Met
         450                 455                 460

 gcc acc tac cgc acc tgc gtg gcc gac gcg aag acg cag aag cag gag     1861
 Ala Thr Tyr Arg Thr Cys Val Ala Asp Ala Lys Thr Gln Lys Gln Glu
     465                 470                 475

 ctg gag gat acc aag gtg acg gcg ctg cgg cag atc cag gag gtc atc     1909
 Leu Glu Asp Thr Lys Val Thr Ala Leu Arg Gln Ile Gln Glu Val Ile
 480                 485                 490                 495

 cgg cag agc gac caa acc atc aag tcg gcc acg atc tcc tac tac cag     1957
 Arg Gln Ser Asp Gln Thr Ile Lys Ser Ala Thr Ile Ser Tyr Tyr Gln
                 500                 505                 510

 atg atg cat atg cag acg gcg ccg ctg ccc gtg cac ttc cag atg ctg     2005
 Met Met His Met Gln Thr Ala Pro Leu Pro Val His Phe Gln Met Leu
             515                 520                 525

 tgt gag agc agc aag ctg tat gac cca ggc cag cag tac gcc tcc cac     2053
 Cys Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His
         530                 535                 540

 gtg cgc cag ctg cag cgg gac cag gag ccc gat gtg cac tac gac ttt     2101
 Val Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val His Tyr Asp Phe
     545                 550                 555

 gag ccc cac gtc tcc gcc aac gcc tgg tcc ccc gtc atg cgt gcc cgg     2149
 Glu Pro His Val Ser Ala Asn Ala Trp Ser Pro Val Met Arg Ala Arg
 560                 565                 570                 575

 aag agc agc ttc aac gtg agt gat gtg gcg cgg ccg gag gct gcc ggg     2197
 Lys Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro Glu Ala Ala Gly
                 580                 585                 590

 agc ccc cca gaa gaa ggc ggg tgc act gag ggc aca cct gcc aag gac     2245
 Ser Pro Pro Glu Glu Gly Gly Cys Thr Glu Gly Thr Pro Ala Lys Asp
             595                 600                 605

 cac agg gcc ggg cga gga cac cag gtt cac aag tca tgg ccg ctc tcg     2293
 His Arg Ala Gly Arg Gly His Gln Val His Lys Ser Trp Pro Leu Ser
         610                 615                 620

 atc tca gac tcg gac agt ggg ctg gac ccc ggc cct ggc gca ggg gac     2341
 Ile Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp
     625                 630                 635

 ttt aag aag ttc gag cgg acg tca tcc agt ggt acc atg tcg tcc acg     2389
 Phe Lys Lys Phe Glu Arg Thr Ser Ser Ser Gly Thr Met Ser Ser Thr
 640                 645                 650                 655

 gag gag ctg gtg gac cca gac ggt gga gcc ggg gct tca gcc ttt gag     2437
 Glu Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu
                 660                 665                 670

 cag gct gac ctc aac ggc atg acc ccc gag ctg ccg gtg gcc gtg ccc     2485
 Gln Ala Asp Leu Asn Gly Met Thr Pro Glu Leu Pro Val Ala Val Pro
             675                 680                 685

 agt gga ccg ttc cgc cac gag ggg ctg tcc aag gcg gcc cgt act cac     2533
 Ser Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala Ala Arg Thr His
         690                 695                 700

 cgg ctc cgg aag ctc cgc acg ccc gcc aag tgc cgc gag tgc aac agc     2581
 Arg Leu Arg Lys Leu Arg Thr Pro Ala Lys Cys Arg Glu Cys Asn Ser
     705                 710                 715

 tac gtc tac ttc cag ggt gct gag tgt gaa gag tgc tgc ctg gcc tgc     2629
 Tyr Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys
 720                 725                 730                 735

 cac aag aaa tgt ctg gag acg ctg gcc ata cag tgc ggg cac aag aag     2677
 His Lys Lys Cys Leu Glu Thr Leu Ala Ile Gln Cys Gly His Lys Lys
                 740                 745                 750

 ctg caa ggc cgc ctg cag ctg ttc ggc cag gac ttc agc cac gcg gcc     2725
 Leu Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe Ser His Ala Ala
             755                 760                 765

 cgc agc gcc ccc gac ggc gtg ccc ttc atc gtc aag aag tgc gtc tgc     2773
 Arg Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys Lys Cys Val Cys
         770                 775                 780

 gag atc gag cgg cgg gcg ctg cgc acc aag ggc atc tac cgg gtc aat     2821
 Glu Ile Glu Arg Arg Ala Leu Arg Thr Lys Gly Ile Tyr Arg Val Asn
     785                 790                 795

 ggg gta aag aca cgc gtg gag aag ctg tgc cag gcc ttc gag aac ggc     2869
 Gly Val Lys Thr Arg Val Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly
 800                 805                 810                 815

 aag gag ctg gtc gag ctg tcg cag gcc tcg ccc cac gac atc agc aac     2917
 Lys Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His Asp Ile Ser Asn
                 820                 825                 830

 gtc ctc aag ctc tac ctg cgt cag ctt ccc gag ccg ctc atc tcc ttc     2965
 Val Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe
             835                 840                 845

 cgc ctc tac cac gag ctc gta ggg ctg gcc aag gac agc ctg aag gca     3013
 Arg Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp Ser Leu Lys Ala
         850                 855                 860

 gag gcc gag gcc aag gcg gcg tcc cgg ggc cgg cag gac ggc tcg gag     3061
 Glu Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu
     865                 870                 875

 agc gag gca gtg gcg gtg gcc ctg gca ggt cgg ctg cgg gag ctc ctg     3109
 Ser Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu
 880                 885                 890                 895

 cgg gac ctg ccg cct gag aac cgg gcc tcg ctg cag tac ctg ctg cgt     3157
 Arg Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg
                 900                 905                 910

 cac cta cgc agg atc gtg gag gtg gag cag gac aac aag atg acc ccc     3205
 His Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn Lys Met Thr Pro
             915                 920                 925

 ggg aac ctg ggc atc gtg ttc ggg ccc acg ctg ctt cgg cca cgg ccc     3253
 Gly Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Leu Arg Pro Arg Pro
         930                 935                 940

 acc gag gcc acc gtg tcc ctc tcc tcc ctg gtg gat tat ccc cat cag     3301
 Thr Glu Ala Thr Val Ser Leu Ser Ser Leu Val Asp Tyr Pro His Gln
     945                 950                 955

 gcc cgc gtc atc gag act ctc atc gtc cac tac ggc ctg gtc ttc gag     3349
 Ala Arg Val Ile Glu Thr Leu Ile Val His Tyr Gly Leu Val Phe Glu
 960                 965                 970                 975

 gag gag ccg gag gag acc ccc ggg ggc cag gac gag tca tcc aac cag     3397
 Glu Glu Pro Glu Glu Thr Pro Gly Gly Gln Asp Glu Ser Ser Asn Gln
                 980                 985                 990

 cga gct gag gta gtc gtc cag gtg ccg tac ctg gag gcg ggc gag gcg     3445
 Arg Ala Glu Val Val Val Gln Val Pro Tyr Leu Glu Ala Gly Glu Ala
             995                1000                1005

 gtg gtc tac ccg ctg cag gag gcg gcg gcg gac ggg tgc aga gaa tcc     3493
 Val Val Tyr Pro Leu Gln Glu Ala Ala Ala Asp Gly Cys Arg Glu Ser
        1010                1015                1020

 cga gtt gtg tcc aac gat tcg gac tcg gac cta gag gag gcc tcc gag     3541
 Arg Val Val Ser Asn Asp Ser Asp Ser Asp Leu Glu Glu Ala Ser Glu
    1025                1030                1035

 ctg ctg tcc tca tcg gag gcc agt gcc ctg ggc cac ctc agc ttc ctg     3589
 Leu Leu Ser Ser Ser Glu Ala Ser Ala Leu Gly His Leu Ser Phe Leu
1040                1045                1050                1055

 gag cag cag cag agc gag gcc agc cta gag gtg gct tct ggc agc cac     3637
 Glu Gln Gln Gln Ser Glu Ala Ser Leu Glu Val Ala Ser Gly Ser His
                1060                1065                1070

 agc ggc agt gag gag cag ctg gag gcc aca gcc cgg gag gac ggg gac     3685
 Ser Gly Ser Glu Glu Gln Leu Glu Ala Thr Ala Arg Glu Asp Gly Asp
            1075                1080                1085

 ggg gac gag gac ggc ccg gcc cag cag ctc tca gga ttc aac acc aac     3733
 Gly Asp Glu Asp Gly Pro Ala Gln Gln Leu Ser Gly Phe Asn Thr Asn
        1090                1095                1100

 cag tcc aac aac gtg ctg cag gcc cca ctg ccc ccc atg agg ctc cgt     3781
 Gln Ser Asn Asn Val Leu Gln Ala Pro Leu Pro Pro Met Arg Leu Arg
    1105                1110                1115

 ggc ggg cgg atg aca ctg ggc tcc tgc agg gaa agg cag ccg gaa ttc     3829
 Gly Gly Arg Met Thr Leu Gly Ser Cys Arg Glu Arg Gln Pro Glu Phe
1120                1125                1130                1135

 gtg tga gctggggtgg ggctgggacc acaggtggct tctctcttgc ctgctcctgt      3885
 Val 


 ccctccagca cgtcccctgc accacggcat agcttaggtg cgccgtcctg gggtcgctgc   3945

 cgagagcgcc tggacttcga cgtcccacca gcgggcgcct cctcccagag gcttccagga   4005

 gcacgagggc cttgcggcac aggactgtgc cctgtgctgt cccctgcacc ccggctcagc   4065

 tgagctgggg aacactgctg tcgtgtgaag tcacagtggc cttgttggtg cccacagggc   4125

 tgtgtggatg gaggaagctg tccctgccca gtgcatcccc caggtcatca cggggacgca   4185

 ggaggcaggc cctgccctgc cctctcctca caggtctgtt gcagggactc cagaaaccat   4245

 tctgggagcc gtggatgggg gcggagctgg ggtttggtgc agtttccagg gtgcagtaca   4305

 gcagggcctg aatactggcc ctggactccc ttttccagaa caccaggtgt ggccacctgg   4365

 ggctcaggta cacagtgggg tctctcggaa gccaccgtgt ggttctttca caggcacgtt   4425

 tattttgctg aaataaaaag tttttaatcg ggaaaaaaaa aaaaa                   4470




      <210> 44
      <211> 1750
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (99)..(923)

      <400> 44
 catgcctcag cgagcaggca tgtagatgta tatctgtcac aattgcaccc ttctaatacg     60

 actcactata tggcatcaaa gatcactaaa ttttagtt    atg att ata tca cat     113
                                              Met Ile Ile Ser His
                                                1               5

 ttt cca aaa tgt gtg gca gtt ttt gcc ctc ctt gct ctg agt gtt ggt      161
 Phe Pro Lys Cys Val Ala Val Phe Ala Leu Leu Ala Leu Ser Val Gly
                  10                  15                  20

 gca ctg gac act ttt att gct gca gta tat gag cat gcg gtg ata tta      209
 Ala Leu Asp Thr Phe Ile Ala Ala Val Tyr Glu His Ala Val Ile Leu
              25                  30                  35

 cca aac aga aca gaa aca cct gtt tca aaa gaa gaa gct ttg ctc ctg      257
 Pro Asn Arg Thr Glu Thr Pro Val Ser Lys Glu Glu Ala Leu Leu Leu
          40                  45                  50

 atg aac aag aac ata gat gtt ttg gag aaa gca gtt aag ctg gca gcg      305
 Met Asn Lys Asn Ile Asp Val Leu Glu Lys Ala Val Lys Leu Ala Ala
      55                  60                  65

 aag cag ggt gca cat atc att gtg acc cca gaa gat gga atc tat ggt      353
 Lys Gln Gly Ala His Ile Ile Val Thr Pro Glu Asp Gly Ile Tyr Gly
  70                  75                  80                  85

 tgg atc ttc acc agg gag agc att tac ccc tat cta gag gat ata cca      401
 Trp Ile Phe Thr Arg Glu Ser Ile Tyr Pro Tyr Leu Glu Asp Ile Pro
                  90                  95                 100

 gac cct gga gtg aac tgg att cca tgt aca gac ccc tgg aga ttc ggc      449
 Asp Pro Gly Val Asn Trp Ile Pro Cys Thr Asp Pro Trp Arg Phe Gly
             105                 110                 115

 aac aca cca gtg caa caa aga ctc agc tgc ctg gcc aag gac aac tct      497
 Asn Thr Pro Val Gln Gln Arg Leu Ser Cys Leu Ala Lys Asp Asn Ser
         120                 125                 130

 atc tat gtc gtg gct aat att ggg gac aag aag cca tgc aat gct agt      545
 Ile Tyr Val Val Ala Asn Ile Gly Asp Lys Lys Pro Cys Asn Ala Ser
     135                 140                 145

 gac tct cag tgt ccc cct gat ggc cgt tac caa tac aac act gat gtg      593
 Asp Ser Gln Cys Pro Pro Asp Gly Arg Tyr Gln Tyr Asn Thr Asp Val
 150                 155                 160                 165

 gtg ttt gat tct cag gga aaa ctg ttg gca cgc tac cat aag tac aat      641
 Val Phe Asp Ser Gln Gly Lys Leu Leu Ala Arg Tyr His Lys Tyr Asn
                 170                 175                 180

 ctt ttt gca cct gaa att cag ttt gat ttc ccc aag gat tca gaa ctt      689
 Leu Phe Ala Pro Glu Ile Gln Phe Asp Phe Pro Lys Asp Ser Glu Leu
             185                 190                 195

 gtg act ttt gac act ccc ttt ggg aag ttt ggc att ttt act tgc ttt      737
 Val Thr Phe Asp Thr Pro Phe Gly Lys Phe Gly Ile Phe Thr Cys Phe
         200                 205                 210

 gac att ttt tct cat gac cca gct gcg gtg gtg gtg gat gag ttt caa      785
 Asp Ile Phe Ser His Asp Pro Ala Ala Val Val Val Asp Glu Phe Gln
     215                 220                 225

 ttg aca gca ttc tct acc cca cag cat ggt aca aca cgc tgc ccc tcc      833
 Leu Thr Ala Phe Ser Thr Pro Gln His Gly Thr Thr Arg Cys Pro Ser
 230                 235                 240                 245

 tct cgg ctg ttc cct tcc att cag cat ggg cca agg cca tgg gag tca      881
 Ser Arg Leu Phe Pro Ser Ile Gln His Gly Pro Arg Pro Trp Glu Ser
                 250                 255                 260

 atc tac ttg ctg caa ata ccc aca aca cca gca tgc aca tga cagggag      930
 Ile Tyr Leu Leu Gln Ile Pro Thr Thr Pro Ala Cys Thr 
             265                 270

 tggaatctac gccccagaag cagtcaaggt gtaccactat gacatggaaa cagagagtgg    990

 tcagctgttg ctatcagaac tgaagtctcg gccccgccgt gagcccacct accctgcagc   1050

 tgttgactgg catgcgtatg ccagcagtgt caagccattt tcctctgaac agtcagattt   1110

 tctggggatg atttattttg atgagtttac cttcaccaag cttaagagaa atacaggaaa   1170

 ttacacagct tgccagaaag atctgtgttg tcacttaact tacaagatgt ctgagaagcg   1230

 aacagacgag atctatgccc taggtgcttt tgatggactg cacacagtag aaggccaata   1290

 ttacttacag atatgtgcat tactgaagtg tcaaaccact gacctggaaa cgtgtggaga   1350

 acctgtgggg tcagctttta ccaagtttga agacttctcc ctcagtggca catttggaac   1410

 gcgttatgtt ttcccacaga tcattctaag tgggagtcag cttgcccctg aaagacatta   1470

 tgagatttca agagatggac gcttgaggag ccgaagtgga gcccctttgc ctgtcttagt   1530

 tatggccctg tatggaagag tgtttgagaa ggaccctcca cgcttagggc agggatctgg   1590

 gaaattccag tgatctcctt tagcagagcc cttttaggat tagcctggct aagaaaggaa   1650

 gaaaaaaaag agatccgtta gtgtctgttt agaaaagatg ttataaactt acagaaacaa   1710

 atataataaa ctgaagcaga tttgaaaagc aaaaaaaaaa                         1750




      <210> 45
      <211> 5607
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (53)..(4885)

      <400> 45
 cggtaccggt ccggaattcc cgggtcgacg atttcgtcgg gacctggccg ag    atg      55
                                                              Met
                                                                1

 ggg agc cca gac gcc gcg gcg gtc gtg cgc aag gac agg ctg cac ccg      103
 Gly Ser Pro Asp Ala Ala Ala Val Val Arg Lys Asp Arg Leu His Pro
               5                  10                  15

 agg caa gtg aga tta tta gag acc ctg agc gaa tac gaa atc gtg tct      151
 Arg Gln Val Arg Leu Leu Glu Thr Leu Ser Glu Tyr Glu Ile Val Ser
          20                  25                  30

 ccc atc cga gtg aac gct ctc gga gaa ccc ttt ccc acg aac gtc cac      199
 Pro Ile Arg Val Asn Ala Leu Gly Glu Pro Phe Pro Thr Asn Val His
      35                  40                  45

 ttc aaa aga acg cga cgg agc att aac tct gcc act gac ccc tgg cct      247
 Phe Lys Arg Thr Arg Arg Ser Ile Asn Ser Ala Thr Asp Pro Trp Pro
  50                  55                  60                  65

 gcc ttc gcc tcc tcc tct tcc tcc tct acc tcc tcc cag gcg cat tac      295
 Ala Phe Ala Ser Ser Ser Ser Ser Ser Thr Ser Ser Gln Ala His Tyr
                  70                  75                  80

 cgc ctc tct gcc ttc ggc cag cag ttt cta ttt aat ctc acc gcc aat      343
 Arg Leu Ser Ala Phe Gly Gln Gln Phe Leu Phe Asn Leu Thr Ala Asn
              85                  90                  95

 gcc gga ttt atc gct cca ctg ttc act gtc acc ctc ctc ggg acg ccc      391
 Ala Gly Phe Ile Ala Pro Leu Phe Thr Val Thr Leu Leu Gly Thr Pro
         100                 105                 110

 ggg gtg aat cag acc aag ttt tat tcc gaa gag gaa gcg gaa ctc aag      439
 Gly Val Asn Gln Thr Lys Phe Tyr Ser Glu Glu Glu Ala Glu Leu Lys
     115                 120                 125

 cac tgt ttc tac aaa ggc tat gtc aat acc aac tcc gag cac acg gcc      487
 His Cys Phe Tyr Lys Gly Tyr Val Asn Thr Asn Ser Glu His Thr Ala
 130                 135                 140                 145

 gtc atc agc ctc tgc tca gga atg ctg ggc aca ttc cgg tct cat gat      535
 Val Ile Ser Leu Cys Ser Gly Met Leu Gly Thr Phe Arg Ser His Asp
                 150                 155                 160

 ggg gat tat ttt att gaa cca cta cag tct atg gat gaa caa gaa gat      583
 Gly Asp Tyr Phe Ile Glu Pro Leu Gln Ser Met Asp Glu Gln Glu Asp
             165                 170                 175

 gaa gag gaa caa aac aaa ccc cac atc att tat agg cgc agc gcc ccc      631
 Glu Glu Glu Gln Asn Lys Pro His Ile Ile Tyr Arg Arg Ser Ala Pro
         180                 185                 190

 cag aga gag ccc tca aca gga agg cat gca tgt gac acc tca gaa cac      679
 Gln Arg Glu Pro Ser Thr Gly Arg His Ala Cys Asp Thr Ser Glu His
     195                 200                 205

 aaa aat agg cac agt aaa gac aag aag aaa acc aga gca aga aaa tgg      727
 Lys Asn Arg His Ser Lys Asp Lys Lys Lys Thr Arg Ala Arg Lys Trp
 210                 215                 220                 225

 gga gaa agg att aac ctg gct ggt gac gta gca gca tta aac agc ggc      775
 Gly Glu Arg Ile Asn Leu Ala Gly Asp Val Ala Ala Leu Asn Ser Gly
                 230                 235                 240

 tta gca aca gag gca ttt tct gct tat ggt aat aag acg gac aac aca      823
 Leu Ala Thr Glu Ala Phe Ser Ala Tyr Gly Asn Lys Thr Asp Asn Thr
             245                 250                 255

 aga gaa aag agg acc cac aga agg aca aaa cgt ttt tta tcc tat cca      871
 Arg Glu Lys Arg Thr His Arg Arg Thr Lys Arg Phe Leu Ser Tyr Pro
         260                 265                 270

 cgg ttt gta gaa gtc ttg gtg gtg gca gac aac aga atg gtt tca tac      919
 Arg Phe Val Glu Val Leu Val Val Ala Asp Asn Arg Met Val Ser Tyr
     275                 280                 285

 cat gga gaa aac ctt caa cac tat att tta act tta atg tca att gta      967
 His Gly Glu Asn Leu Gln His Tyr Ile Leu Thr Leu Met Ser Ile Val
 290                 295                 300                 305

 gcc tct atc tat aaa gac cca agt att gga aat tta att aat att gtt     1015
 Ala Ser Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu Ile Asn Ile Val
                 310                 315                 320

 att gtg aac tta att gtg att cat aat gaa cag gat ggg cct tcc ata     1063
 Ile Val Asn Leu Ile Val Ile His Asn Glu Gln Asp Gly Pro Ser Ile
             325                 330                 335

 tct ttt aat gct cag aca aca tta aaa aac ttt tgc cag tgg cag cat     1111
 Ser Phe Asn Ala Gln Thr Thr Leu Lys Asn Phe Cys Gln Trp Gln His
         340                 345                 350

 tcg aag aac agt cca ggt gga atc cat cat gat act gct gtt ctc tta     1159
 Ser Lys Asn Ser Pro Gly Gly Ile His His Asp Thr Ala Val Leu Leu
     355                 360                 365

 aca aga cag gat atc tgc aga gct cac gac aaa tgt gat acc tta ggc     1207
 Thr Arg Gln Asp Ile Cys Arg Ala His Asp Lys Cys Asp Thr Leu Gly
 370                 375                 380                 385

 ctg gct gaa ctg gga acc att tgt gat ccc tat aga agc tgt tct att     1255
 Leu Ala Glu Leu Gly Thr Ile Cys Asp Pro Tyr Arg Ser Cys Ser Ile
                 390                 395                 400

 agt gaa gat agt gga ttg agt aca gct ttt acg atc gcc cat gag ctg     1303
 Ser Glu Asp Ser Gly Leu Ser Thr Ala Phe Thr Ile Ala His Glu Leu
             405                 410                 415

 ggc cat gtg ttt aac atg cct cat gat gac aac aac aaa tgt aaa gaa     1351
 Gly His Val Phe Asn Met Pro His Asp Asp Asn Asn Lys Cys Lys Glu
         420                 425                 430

 gaa gga gtt aag agt ccc cag cat gtc atg gct cca aca ctg aac ttc     1399
 Glu Gly Val Lys Ser Pro Gln His Val Met Ala Pro Thr Leu Asn Phe
     435                 440                 445

 tac acc aac ccc tgg atg tgg tca aag tgt agt cga aaa tat atc act     1447
 Tyr Thr Asn Pro Trp Met Trp Ser Lys Cys Ser Arg Lys Tyr Ile Thr
 450                 455                 460                 465

 gag ttt tta gac act ggt tat ggc gag tgt ttg ctt aac gaa cct gaa     1495
 Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu Asn Glu Pro Glu
                 470                 475                 480

 tcc aga ccc tac cct ttg cct gtc caa ctg cca ggc atc ctt tac aac     1543
 Ser Arg Pro Tyr Pro Leu Pro Val Gln Leu Pro Gly Ile Leu Tyr Asn
             485                 490                 495

 gtg aat aaa caa tgt gaa ttg att ttt gga cca ggt tct cag gtg tgc     1591
 Val Asn Lys Gln Cys Glu Leu Ile Phe Gly Pro Gly Ser Gln Val Cys
         500                 505                 510

 cca tat atg atg cag tgc aga cgg ctc tgg tgc aat aac gtc aat gga     1639
 Pro Tyr Met Met Gln Cys Arg Arg Leu Trp Cys Asn Asn Val Asn Gly
     515                 520                 525

 gta cac aaa ggc tgc cgg act cag cac aca ccc tgg gcc gat ggg acg     1687
 Val His Lys Gly Cys Arg Thr Gln His Thr Pro Trp Ala Asp Gly Thr
 530                 535                 540                 545

 gag tgc gag cct gga aag cac tgc aag tat gga ttt tgt gtt ccc aaa     1735
 Glu Cys Glu Pro Gly Lys His Cys Lys Tyr Gly Phe Cys Val Pro Lys
                 550                 555                 560

 gaa atg gat gtc ccc gtg aca gat gga tcc tgg gga agt tgg agt ccc     1783
 Glu Met Asp Val Pro Val Thr Asp Gly Ser Trp Gly Ser Trp Ser Pro
             565                 570                 575

 ttt gga acc tgc tcc aga aca tgt gga ggg ggc atc aaa aca gcc att     1831
 Phe Gly Thr Cys Ser Arg Thr Cys Gly Gly Gly Ile Lys Thr Ala Ile
         580                 585                 590

 cga gag tgc aac aga cca gaa cca aaa aat ggt gga aaa tac tgt gta     1879
 Arg Glu Cys Asn Arg Pro Glu Pro Lys Asn Gly Gly Lys Tyr Cys Val
     595                 600                 605

 gga cgt aga atg aaa ttt aag tcc tgc aac acg gag cca tgt ctc aag     1927
 Gly Arg Arg Met Lys Phe Lys Ser Cys Asn Thr Glu Pro Cys Leu Lys
 610                 615                 620                 625

 cag aag cga gac ttc cga gat gaa cag tgt gct cac ttt gac ggg aag     1975
 Gln Lys Arg Asp Phe Arg Asp Glu Gln Cys Ala His Phe Asp Gly Lys
                 630                 635                 640

 cat ttt aac atc aac ggt ctg ctt ccc aat gtg cgc tgg gtc cct aaa     2023
 His Phe Asn Ile Asn Gly Leu Leu Pro Asn Val Arg Trp Val Pro Lys
             645                 650                 655

 tac agt gga att ctg atg aag gac cgg tgc aag ttg ttc tgc aga gtg     2071
 Tyr Ser Gly Ile Leu Met Lys Asp Arg Cys Lys Leu Phe Cys Arg Val
         660                 665                 670

 gca ggg aac aca gcc tac tat cag ctt cga gac aga gtg ata gat gga     2119
 Ala Gly Asn Thr Ala Tyr Tyr Gln Leu Arg Asp Arg Val Ile Asp Gly
     675                 680                 685

 act cct tgt ggc cag gac aca aat gat atc tgt gtc cag ggc ctt tgc     2167
 Thr Pro Cys Gly Gln Asp Thr Asn Asp Ile Cys Val Gln Gly Leu Cys
 690                 695                 700                 705

 cgg caa gct gga tgc gat cat gtt tta aac tca aaa gcc cgg aga gat     2215
 Arg Gln Ala Gly Cys Asp His Val Leu Asn Ser Lys Ala Arg Arg Asp
                 710                 715                 720

 aaa tgt ggg gtt tgt ggt ggc gat aat tct tca tgc aaa aca gtg gca     2263
 Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Lys Thr Val Ala
             725                 730                 735

 gga aca ttt aat aca gta cat tat ggt tac aat act gtg gtc cga att     2311
 Gly Thr Phe Asn Thr Val His Tyr Gly Tyr Asn Thr Val Val Arg Ile
         740                 745                 750

 cca gct ggt gct acc aat att gat gtg cgg cag cac agt ttc tca ggg     2359
 Pro Ala Gly Ala Thr Asn Ile Asp Val Arg Gln His Ser Phe Ser Gly
     755                 760                 765

 gaa aca gac gat gac aac tac tta gct tta tca agc agt aaa ggt gaa     2407
 Glu Thr Asp Asp Asp Asn Tyr Leu Ala Leu Ser Ser Ser Lys Gly Glu
 770                 775                 780                 785

 ttc ttg cta aat gga aac ttt gtt gtc aca atg gcc aaa agg gaa att     2455
 Phe Leu Leu Asn Gly Asn Phe Val Val Thr Met Ala Lys Arg Glu Ile
                 790                 795                 800

 cgc att ggg aat gct gtg gta gag tac agt ggg tcc gag act gcc gta     2503
 Arg Ile Gly Asn Ala Val Val Glu Tyr Ser Gly Ser Glu Thr Ala Val
             805                 810                 815

 gaa aga att aac tca aca gat cgc att gag caa gaa ctt ttg ctt cag     2551
 Glu Arg Ile Asn Ser Thr Asp Arg Ile Glu Gln Glu Leu Leu Leu Gln
         820                 825                 830

 gtt ttg tcg gtg gga aag ttg tac aac ccc gat gta cgc tat tct ttc     2599
 Val Leu Ser Val Gly Lys Leu Tyr Asn Pro Asp Val Arg Tyr Ser Phe
     835                 840                 845

 aat att cca att gaa gat aaa cct cag cag ttt tac tgg aac agt cat     2647
 Asn Ile Pro Ile Glu Asp Lys Pro Gln Gln Phe Tyr Trp Asn Ser His
 850                 855                 860                 865

 ggg cca tgg caa gca tgc agt aaa ccc tgc caa ggg gaa cgg aaa cga     2695
 Gly Pro Trp Gln Ala Cys Ser Lys Pro Cys Gln Gly Glu Arg Lys Arg
                 870                 875                 880

 aaa ctt gtt tgc acc agg gaa tct gat cag ctt act gtt tct gat caa     2743
 Lys Leu Val Cys Thr Arg Glu Ser Asp Gln Leu Thr Val Ser Asp Gln
             885                 890                 895

 aga tgc gat cgg ctg ccc cag cct gga cac att act gaa ccc tgt ggt     2791
 Arg Cys Asp Arg Leu Pro Gln Pro Gly His Ile Thr Glu Pro Cys Gly
         900                 905                 910

 aca gac tgt gac ctg agg tgg cat gtt gcc agc agg agt gaa tgt agt     2839
 Thr Asp Cys Asp Leu Arg Trp His Val Ala Ser Arg Ser Glu Cys Ser
     915                 920                 925

 gcc cag tgt ggc ttg ggt tac cgc aca ttg gac atc tac tgt gcc aaa     2887
 Ala Gln Cys Gly Leu Gly Tyr Arg Thr Leu Asp Ile Tyr Cys Ala Lys
 930                 935                 940                 945

 tat agc agg ctg gat ggg aag act gag aag gtt gat gat ggt ttt tgc     2935
 Tyr Ser Arg Leu Asp Gly Lys Thr Glu Lys Val Asp Asp Gly Phe Cys
                 950                 955                 960

 agc agc cat ccc aaa cca agc aac cgt gaa aaa tgc tca ggg gaa tgt     2983
 Ser Ser His Pro Lys Pro Ser Asn Arg Glu Lys Cys Ser Gly Glu Cys
             965                 970                 975

 aac acg ggt ggc tgg cgc tat tct gcc tgg act gaa tgt tca aaa agc     3031
 Asn Thr Gly Gly Trp Arg Tyr Ser Ala Trp Thr Glu Cys Ser Lys Ser
         980                 985                 990

 tgt gac ggt ggg acc cag agg aga agg gct att tgt gtc aat acc cga     3079
 Cys Asp Gly Gly Thr Gln Arg Arg Arg Ala Ile Cys Val Asn Thr Arg
     995                1000                1005

 aat gat gta ctg gat gac agc aaa tgc aca cat caa gag aaa gtt acc     3127
 Asn Asp Val Leu Asp Asp Ser Lys Cys Thr His Gln Glu Lys Val Thr
1010                1015                1020                1025

 att cag agg tgc agt gag ttc cct tgt cca cag tgg aaa tct gga gac     3175
 Ile Gln Arg Cys Ser Glu Phe Pro Cys Pro Gln Trp Lys Ser Gly Asp
                1030                1035                1040

 tgg tca gag tgc ttg gtc acc tgt gga aaa ggg cat aag cac cgc cag     3223
 Trp Ser Glu Cys Leu Val Thr Cys Gly Lys Gly His Lys His Arg Gln
            1045                1050                1055

 gtc tgg tgt cag ttt ggt gaa gat cga tta aat gat aga atg tgt gac     3271
 Val Trp Cys Gln Phe Gly Glu Asp Arg Leu Asn Asp Arg Met Cys Asp
        1060                1065                1070

 cct gag acc aag cca aca tct atg cag act tgt cag cag ccg gaa tgt     3319
 Pro Glu Thr Lys Pro Thr Ser Met Gln Thr Cys Gln Gln Pro Glu Cys
    1075                1080                1085

 gca tcc tgg cag gcg ggt ccc tgg gga cag tgc agt gtc act tgt gga     3367
 Ala Ser Trp Gln Ala Gly Pro Trp Gly Gln Cys Ser Val Thr Cys Gly
1090                1095                1100                1105

 cag gga tac cag cta aga gca gtg aaa tgc atc att ggg act tat atg     3415
 Gln Gly Tyr Gln Leu Arg Ala Val Lys Cys Ile Ile Gly Thr Tyr Met
                1110                1115                1120

 tca gtg gta gat gac aat gac tgt aat gca gca act aga cca act gat     3463
 Ser Val Val Asp Asp Asn Asp Cys Asn Ala Ala Thr Arg Pro Thr Asp
            1125                1130                1135

 acc cag gac tgt gaa tta cca tca tgt cat cct ccc cca gct gcc ccg     3511
 Thr Gln Asp Cys Glu Leu Pro Ser Cys His Pro Pro Pro Ala Ala Pro
        1140                1145                1150

 gaa acg agg aga agc aca tac agt gca cca aga acc cag tgg cga ttt     3559
 Glu Thr Arg Arg Ser Thr Tyr Ser Ala Pro Arg Thr Gln Trp Arg Phe
    1155                1160                1165

 ggg tct tgg acc cca tgc tca gcc act tgt ggg aaa ggt acc cgg atg     3607
 Gly Ser Trp Thr Pro Cys Ser Ala Thr Cys Gly Lys Gly Thr Arg Met
1170                1175                1180                1185

 aga tac gtc agc tgc cga gat gag aat ggc tct gtg gct gac gag agt     3655
 Arg Tyr Val Ser Cys Arg Asp Glu Asn Gly Ser Val Ala Asp Glu Ser
                1190                1195                1200

 gcc tgt gct acc ctg cct aga cca gtg gca aag gaa gaa tgt tct gtg     3703
 Ala Cys Ala Thr Leu Pro Arg Pro Val Ala Lys Glu Glu Cys Ser Val
            1205                1210                1215

 aca ccc tgt ggg caa tgg aag gcc ttg gac tgg agc tct tgc tct gtg     3751
 Thr Pro Cys Gly Gln Trp Lys Ala Leu Asp Trp Ser Ser Cys Ser Val
        1220                1225                1230

 acc tgt ggg caa ggt agg gca acc cgg caa gtg atg tgt gtc aac tac     3799
 Thr Cys Gly Gln Gly Arg Ala Thr Arg Gln Val Met Cys Val Asn Tyr
    1235                1240                1245

 agt gac cac gtg atc gat cgg agt gag tgt gac cag gat tat atc cca     3847
 Ser Asp His Val Ile Asp Arg Ser Glu Cys Asp Gln Asp Tyr Ile Pro
1250                1255                1260                1265

 gaa act gac cag gac tgt tcc atg tca cca tgc cct caa agg acc cca     3895
 Glu Thr Asp Gln Asp Cys Ser Met Ser Pro Cys Pro Gln Arg Thr Pro
                1270                1275                1280

 gac agt ggc tta gct cag cac ccc ttc caa aat gag gac tat cgt ccc     3943
 Asp Ser Gly Leu Ala Gln His Pro Phe Gln Asn Glu Asp Tyr Arg Pro
            1285                1290                1295

 cgg agc gcc agc ccc agc cgc acc cat gtg ctc ggt gga aac cag tgg     3991
 Arg Ser Ala Ser Pro Ser Arg Thr His Val Leu Gly Gly Asn Gln Trp
        1300                1305                1310

 aga act ggc ccc tgg gga gca tgt tcc agt acc tgt gct ggc gga tcc     4039
 Arg Thr Gly Pro Trp Gly Ala Cys Ser Ser Thr Cys Ala Gly Gly Ser
    1315                1320                1325

 cag cgg cgt gtt gtt gta tgt cag gat gaa aat gga tac acc gca aac     4087
 Gln Arg Arg Val Val Val Cys Gln Asp Glu Asn Gly Tyr Thr Ala Asn
1330                1335                1340                1345

 gac tgt gtg gag aga ata aaa cct gat gag caa aga gcc tgt gaa tcc     4135
 Asp Cys Val Glu Arg Ile Lys Pro Asp Glu Gln Arg Ala Cys Glu Ser
                1350                1355                1360

 ggc cct tgt cct cag tgg gct tat ggc aac tgg gga gag tgc act aag     4183
 Gly Pro Cys Pro Gln Trp Ala Tyr Gly Asn Trp Gly Glu Cys Thr Lys
            1365                1370                1375

 ctg tgt ggt gga ggc ata aga aca aga ctg gtg gtc tgt cag cgg tcc     4231
 Leu Cys Gly Gly Gly Ile Arg Thr Arg Leu Val Val Cys Gln Arg Ser
        1380                1385                1390

 aac ggt gaa cgg ttt cca gat ttg agc tgt gaa att ctt gat aaa cct     4279
 Asn Gly Glu Arg Phe Pro Asp Leu Ser Cys Glu Ile Leu Asp Lys Pro
    1395                1400                1405

 ccc gat cgt gag cag tgt aac aca cat gct tgt cca cac gac gct gca     4327
 Pro Asp Arg Glu Gln Cys Asn Thr His Ala Cys Pro His Asp Ala Ala
1410                1415                1420                1425

 tgg agt act ggc cct tgg agc tcg tgt tct gtc tct tgt ggt cga ggg     4375
 Trp Ser Thr Gly Pro Trp Ser Ser Cys Ser Val Ser Cys Gly Arg Gly
                1430                1435                1440

 cat aaa caa cga aat gtt tac tgc atg gca aaa gat gga agc cat tta     4423
 His Lys Gln Arg Asn Val Tyr Cys Met Ala Lys Asp Gly Ser His Leu
            1445                1450                1455

 gaa agt gat tac tgt aag cac ctg gct aag cca cat ggg cac aga aag     4471
 Glu Ser Asp Tyr Cys Lys His Leu Ala Lys Pro His Gly His Arg Lys
        1460                1465                1470

 tgc cga gga gga aga tgc ccc aaa tgg aaa gct ggc gct tgg agt cag     4519
 Cys Arg Gly Gly Arg Cys Pro Lys Trp Lys Ala Gly Ala Trp Ser Gln
    1475                1480                1485

 tgc tct gtg tcc tgt ggc cga ggc gta cag cag agg cat gtg ggc tgt     4567
 Cys Ser Val Ser Cys Gly Arg Gly Val Gln Gln Arg His Val Gly Cys
1490                1495                1500                1505

 cag atc gga aca cac aaa ata gcc aga gag acc gag tgc aac cca tac     4615
 Gln Ile Gly Thr His Lys Ile Ala Arg Glu Thr Glu Cys Asn Pro Tyr
                1510                1515                1520

 acc aga ccg gag tcg gaa cgc gac tgc caa ggc cca cgg tgt ccc ctc     4663
 Thr Arg Pro Glu Ser Glu Arg Asp Cys Gln Gly Pro Arg Cys Pro Leu
            1525                1530                1535

 tac act tgg agg gca gag gaa tgg caa gaa tgc acc aag acc tgc ggc     4711
 Tyr Thr Trp Arg Ala Glu Glu Trp Gln Glu Cys Thr Lys Thr Cys Gly
        1540                1545                1550

 gaa ggc tcc agg tac cgc aag gtg gtg tgt gtg gat gac aac aaa aac     4759
 Glu Gly Ser Arg Tyr Arg Lys Val Val Cys Val Asp Asp Asn Lys Asn
    1555                1560                1565

 gag gtg cat ggg gca cgc tgt gac gtg agc aag cgg ccg gtg gac cgt     4807
 Glu Val His Gly Ala Arg Cys Asp Val Ser Lys Arg Pro Val Asp Arg
1570                1575                1580                1585

 gaa agc tgt agt ttg caa ccc tgc gag tat gtc tgg atc aca gga gaa     4855
 Glu Ser Cys Ser Leu Gln Pro Cys Glu Tyr Val Trp Ile Thr Gly Glu
                1590                1595                1600

 tgg tca gag gta ccg tcc tgg gaa ctg taa c catcgtcagc tcagccatgg     4906
 Trp Ser Glu Val Pro Ser Trp Glu Leu 
            1605                1610

 cctgagagtg gcagagggat gagtggaggg atgagtgcag gaatgtggga gacttgaggc   4966

 tacccgcccg atttgccact gtgaactgtg tgttttctga caagtcctca gctttcccaa   5026

 gctagaattc cttgtatgca aagcgggaga gatgtaagag atggtctcta agtcccttca   5086

 ggtctacatt ctgtgattca ccttgatgtc ctattggcat aaagaagaaa ttattacagg   5146

 ggctgcaaac tcataggatg ctgtgaggtg cctgaagaca gttaagtata agaaaatatt   5206

 gtagtgccag ggatacaaca aggagagatg gcaactgtga caaactagca catgctgtgt   5266

 gaagggagca gaatctcttt cactccagct gtggccatgc agaaatgtgg tctagcgtta   5326

 ccagacctga tttttcaaga gaggctaaaa atctggacta gtatgtgaga tttcctaact   5386

 tgaaaatggg ggctgaaatt tttggtttta aaacattgta aggggcaaac aaaccccttt   5446

 catgaaccag atgtgttgtg cctgtttaac aaacagcttc agaggaagaa aataattttc   5506

 tataatatcc gaagtatctc aagtaccatt ttttcatata tcttcctgtg cacaatgctt   5566

 atctagaccc tttttaatgg taataaacca gtagtaatca t                       5607




      <210> 46
      <211> 1755
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (153)..(1409)

      <400> 46
 gtgaagaagg cgggaagtta atcctcttcc aatcagctcc ccatctcgcc ctctggcggc     60

 tccggaccac aggccgagtt actctgatta ccgccatgct ccaagacccg cactgacagt    120

 ccccacgtga gggaccgcgg tgggagtcct aa  atg ggg gag gag ggg acg ggc     173
                                      Met Gly Glu Glu Gly Thr Gly
                                        1               5

 ggc act gtg cat ctg ctg tgc ctc gcg gcc tcc agc ggg gtc ccc cta      221
 Gly Thr Val His Leu Leu Cys Leu Ala Ala Ser Ser Gly Val Pro Leu
          10                  15                  20

 ttc tgc agg agc agt cgc ggc ggc gcc ccc gcc cgt cag cag ctc ccg      269
 Phe Cys Arg Ser Ser Arg Gly Gly Ala Pro Ala Arg Gln Gln Leu Pro
      25                  30                  35

 ttc tct gtc atc ggt tcc ctc aat gga gtc cac atg ttt ggg cag aat      317
 Phe Ser Val Ile Gly Ser Leu Asn Gly Val His Met Phe Gly Gln Asn
  40                  45                  50                  55

 ctg gag gtg cag ctg agc tct gcg agg acc gag aac acg act gtg gtg      365
 Leu Glu Val Gln Leu Ser Ser Ala Arg Thr Glu Asn Thr Thr Val Val
                  60                  65                  70

 tgg aaa agc ttc cat gac agc atc acc ctc att gtt ctg tca tct gag      413
 Trp Lys Ser Phe His Asp Ser Ile Thr Leu Ile Val Leu Ser Ser Glu
              75                  80                  85

 gtg ggc atc tct gag ctg agg ctg gag aga cta ctc caa atg gtg ttt      461
 Val Gly Ile Ser Glu Leu Arg Leu Glu Arg Leu Leu Gln Met Val Phe
          90                  95                 100

 gga gcc atg gtc ctt ctt gtg gga ctt gaa gaa ctg acc aat atc cgc      509
 Gly Ala Met Val Leu Leu Val Gly Leu Glu Glu Leu Thr Asn Ile Arg
     105                 110                 115

 aac gtg gag aga ctg aag aag gac ttg agg gcc agt tat tgc ctc atc      557
 Asn Val Glu Arg Leu Lys Lys Asp Leu Arg Ala Ser Tyr Cys Leu Ile
 120                 125                 130                 135

 gac agc ttc ctg ggg gac tcg gag ctc atc ggg gac ctg acc cag tgt      605
 Asp Ser Phe Leu Gly Asp Ser Glu Leu Ile Gly Asp Leu Thr Gln Cys
                 140                 145                 150

 gtg gac tgc gtg att cct cca gag ggg tcc ctc ttg cag gaa gcc ctc      653
 Val Asp Cys Val Ile Pro Pro Glu Gly Ser Leu Leu Gln Glu Ala Leu
             155                 160                 165

 tcc ggg ttc gct gag gcc gcg ggc acg acc ttc gtc agt ctg gtg gtg      701
 Ser Gly Phe Ala Glu Ala Ala Gly Thr Thr Phe Val Ser Leu Val Val
         170                 175                 180

 tcc ggc cgg gtg gtg gca gca aca gag ggt tgg tgg cgg ctg ggg acg      749
 Ser Gly Arg Val Val Ala Ala Thr Glu Gly Trp Trp Arg Leu Gly Thr
     185                 190                 195

 ccc gag gcc gtg ctg ctc ccc tgg ctg gtg ggg tcc ctg ccg ccg cag      797
 Pro Glu Ala Val Leu Leu Pro Trp Leu Val Gly Ser Leu Pro Pro Gln
 200                 205                 210                 215

 acc gct cgc gac tac ccg gtg tac ctg ccg cac ggg agc ccc acg gtc      845
 Thr Ala Arg Asp Tyr Pro Val Tyr Leu Pro His Gly Ser Pro Thr Val
                 220                 225                 230

 cca cac cgg ctc ctg acc ctg act ctg ctg ccg agc ctg gag ctg tgt      893
 Pro His Arg Leu Leu Thr Leu Thr Leu Leu Pro Ser Leu Glu Leu Cys
             235                 240                 245

 cta ctc tgc ggg ccg agc cca ccc ctc agc cag ttg tat cca cag ctt      941
 Leu Leu Cys Gly Pro Ser Pro Pro Leu Ser Gln Leu Tyr Pro Gln Leu
         250                 255                 260

 ctg gag cgc tgg tgg cag cca ctg ctg gac ccg ttg cgg gcc tgt ctg      989
 Leu Glu Arg Trp Trp Gln Pro Leu Leu Asp Pro Leu Arg Ala Cys Leu
     265                 270                 275

 ccg ttg gga ccc cgg gcg ctg ccc agt ggc ttc ccc ctt cac aca gac     1037
 Pro Leu Gly Pro Arg Ala Leu Pro Ser Gly Phe Pro Leu His Thr Asp
 280                 285                 290                 295

 atc ctc ggg ctg ctg ctc ctc cac ctg gaa ctg aag cgc tgc ctc ttc     1085
 Ile Leu Gly Leu Leu Leu Leu His Leu Glu Leu Lys Arg Cys Leu Phe
                 300                 305                 310

 acc gtg gag ccc ttg ggg gat aaa gag cct tca cca gaa cag cgc cgg     1133
 Thr Val Glu Pro Leu Gly Asp Lys Glu Pro Ser Pro Glu Gln Arg Arg
             315                 320                 325

 cgc ctc ctc cga aac ttc tat acc ctg gtc acc tcc acg cac ttc cca     1181
 Arg Leu Leu Arg Asn Phe Tyr Thr Leu Val Thr Ser Thr His Phe Pro
         330                 335                 340

 cca gag cca ggg cca cca gag aag aca gaa gat gag gtc tac cag gcc     1229
 Pro Glu Pro Gly Pro Pro Glu Lys Thr Glu Asp Glu Val Tyr Gln Ala
     345                 350                 355

 cag ctg ccc aga gct tgc tac ctg gtg ttg ggg act gag gaa cca ggc     1277
 Gln Leu Pro Arg Ala Cys Tyr Leu Val Leu Gly Thr Glu Glu Pro Gly
 360                 365                 370                 375

 aca gga gtg cgt ctg gtg gcc ttg cag ctg ggg ctt cgg cgg ctg ctg     1325
 Thr Gly Val Arg Leu Val Ala Leu Gln Leu Gly Leu Arg Arg Leu Leu
                 380                 385                 390

 ctg ctg ctg tct ccc cag agt ccc acc cat ggg ctg cga agc ctg gcc     1373
 Leu Leu Leu Ser Pro Gln Ser Pro Thr His Gly Leu Arg Ser Leu Ala
             395                 400                 405

 acc cac act ctg cat gcc ctc acc cca ctt ctt tga ctac ctagcagtgg     1423
 Thr His Thr Leu His Ala Leu Thr Pro Leu Leu 
         410                 415

 gtgatggaca cagacatggg gctgttagcg tctctctgtt tattcgctca caataataca   1483

 cagcccctgg atggggaggg ggcagtaaga ccacgaacgc ttaccttttg ctgccattat   1543

 gtactgtagc tcctgtgtgc gcgcttacat gtgattgacg ttacataagc agaggccctt   1603

 gctttgttcc tctcctccag gggactcata ttctggttgg agcgcctccc cggtgtccta   1663

 tcctgggggg gggggagggg cgccgtcttc cctacgcgca attcctgcag gaggtgccgc   1723

 gcccccgatc gcgttcggct gtcggcgcgg cc                                 1755




      <210> 47
      <211> 1839
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (191)..(1513)

      <400> 47
 tttctttgcc ctctgggagc tcacagttta tttagggaga taggctatac acaggaaaca     60

 gtaacaaggg ctgccagctc ccagccctcc ctcactccag ctgttctctc cagttcttcc    120

 agatgtcctc caggtgtctg ctgccccccc agggccccga ggccgccagg ccccaacctc    180

 acccccacgc   atg acg gtg cat gag ggg cag gag ctg gca ctg ggc tgc     229
              Met Thr Val His Glu Gly Gln Glu Leu Ala Leu Gly Cys
                1               5                  10

 ctg gcg agg aca agc aca cag aag cac aca cac ctg gca gtg tcc ttt      277
 Leu Ala Arg Thr Ser Thr Gln Lys His Thr His Leu Ala Val Ser Phe
      15                  20                  25

 ggg cga tct gtg ccc gag gca cca gtt ggg cgg tca act ctg cag gaa      325
 Gly Arg Ser Val Pro Glu Ala Pro Val Gly Arg Ser Thr Leu Gln Glu
  30                  35                  40                  45

 gtg gtg gga atc cgg tca gac ttg gcc gtg gag gct gga gct ccc tat      373
 Val Val Gly Ile Arg Ser Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr
                  50                  55                  60

 gct gag cga ttg gct gca ggg gag ctt cgt ctg ggc aag gaa ggg acc      421
 Ala Glu Arg Leu Ala Ala Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr
              65                  70                  75

 gat cgg tac cgc atg gta gta ggg ggt gcc cag gca ggg gac gca ggc      469
 Asp Arg Tyr Arg Met Val Val Gly Gly Ala Gln Ala Gly Asp Ala Gly
          80                  85                  90

 acc tac cac tgc act gcc gct gag tgg att cag gat cct gat ggc agc      517
 Thr Tyr His Cys Thr Ala Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser
      95                 100                 105

 tgg gcc cag att gca gag aaa agg gcc gtc ctg gcc cac gtg gat gtg      565
 Trp Ala Gln Ile Ala Glu Lys Arg Ala Val Leu Ala His Val Asp Val
 110                 115                 120                 125

 cag acg ctg tcc agc cag ctg gca gtg aca gtg ggg cct ggt gaa cgt      613
 Gln Thr Leu Ser Ser Gln Leu Ala Val Thr Val Gly Pro Gly Glu Arg
                 130                 135                 140

 cgg atc ggc cca ggg gag ccc ttg gaa ctg ctg tgc aat gtg tca ggg      661
 Arg Ile Gly Pro Gly Glu Pro Leu Glu Leu Leu Cys Asn Val Ser Gly
             145                 150                 155

 gca ctt ccc cca gca ggc cgt cat gct gca tac tct gta ggt tgg gag      709
 Ala Leu Pro Pro Ala Gly Arg His Ala Ala Tyr Ser Val Gly Trp Glu
         160                 165                 170

 atg gca cct gcg ggg gca cct ggg ccc ggc cgc ctg gta gcc cag ctg      757
 Met Ala Pro Ala Gly Ala Pro Gly Pro Gly Arg Leu Val Ala Gln Leu
     175                 180                 185

 gac aca gag ggt gtg ggc agc ctg ggc cct ggc tat gag ggc cga cac      805
 Asp Thr Glu Gly Val Gly Ser Leu Gly Pro Gly Tyr Glu Gly Arg His
 190                 195                 200                 205

 att gcc atg gag aag gtg gca tcc aga aca tac cgg cta cgg cta gag      853
 Ile Ala Met Glu Lys Val Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu
                 210                 215                 220

 gct gcc agg cct ggt gat gcg ggc acc tac cgc tgc ctc gcc aaa gcc      901
 Ala Ala Arg Pro Gly Asp Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala
             225                 230                 235

 tat gtt cga ggg tct ggg acc cgg ctt cgt gaa gca gcc agt gcc cgt      949
 Tyr Val Arg Gly Ser Gly Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg
         240                 245                 250

 tcc cgg cct ctc cct gta cat gtg cgg gag gaa ggt gtg gtg ctg gag      997
 Ser Arg Pro Leu Pro Val His Val Arg Glu Glu Gly Val Val Leu Glu
     255                 260                 265

 gct gtg gca tgg cta gca gga ggc aca gtg tac cgc ggg gag act gcc     1045
 Ala Val Ala Trp Leu Ala Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala
 270                 275                 280                 285

 tcc ctg ctg tgc aac atc tct gtg cgg ggt ggc ccc cca gga ctg cgg     1093
 Ser Leu Leu Cys Asn Ile Ser Val Arg Gly Gly Pro Pro Gly Leu Arg
                 290                 295                 300

 ctg gcc gcc agc tgg tgg gtg gag cga cca gag gac gga gag ctc agc     1141
 Leu Ala Ala Ser Trp Trp Val Glu Arg Pro Glu Asp Gly Glu Leu Ser
             305                 310                 315

 tct gtc cct gcc cag ctg gtg ggt ggc gta ggc cag gat ggt gtg gca     1189
 Ser Val Pro Ala Gln Leu Val Gly Gly Val Gly Gln Asp Gly Val Ala
         320                 325                 330

 gag ctg gga gtc cgg cct gga gga ggc cct gtc agc gta gag ctg gtg     1237
 Glu Leu Gly Val Arg Pro Gly Gly Gly Pro Val Ser Val Glu Leu Val
     335                 340                 345

 ggg ccc cga agc cat cgg ctg aga cta cac agc ttg ggg ccc gag gat     1285
 Gly Pro Arg Ser His Arg Leu Arg Leu His Ser Leu Gly Pro Glu Asp
 350                 355                 360                 365

 gaa ggc gtg tac cac tgt gcc ccc agc gcc tgg gtg cag cat gcc gac     1333
 Glu Gly Val Tyr His Cys Ala Pro Ser Ala Trp Val Gln His Ala Asp
                 370                 375                 380

 tac agc tgg tac cag gcg ggc agt gcc cgc tca ggg cct gtt aca gtc     1381
 Tyr Ser Trp Tyr Gln Ala Gly Ser Ala Arg Ser Gly Pro Val Thr Val
             385                 390                 395

 tac ccc tac atg cat gcc ctg gac acc cta ttt gtg cct ctg ctg gtg     1429
 Tyr Pro Tyr Met His Ala Leu Asp Thr Leu Phe Val Pro Leu Leu Val
         400                 405                 410

 ggt aca ggg gtg gcc cta gtc act ggt gcc act gtc ctt ggt acc atc     1477
 Gly Thr Gly Val Ala Leu Val Thr Gly Ala Thr Val Leu Gly Thr Ile
     415                 420                 425

 act tgc tgc ttc atg aag agg ctt cga aaa cgg tga tccc ttactcccca     1527
 Thr Cys Cys Phe Met Lys Arg Leu Arg Lys Arg 
 430                 435                 440

 gcccacaccg ggcacccttt tcaggtcttg caggtgtcga ctgtcttccg gcccagctcc   1587

 aagccctcct ctggttgcct ggacaccctc tccctctgtc cactcttcct ttaatttatt   1647

 tgacctccca ctacccagaa tgggagacgt gcctcccctt ccccactcct tccctcccaa   1707

 gcccctccct ctggccttct gttcttgatc tcttagggat cctataggga ggccatttcc   1767

 tgtcctggaa ttagtttttc taaaatgtga ataaacttgt tttataaaaa gcaaaaaaaa   1827

 aaaaaaaaaa aa                                                       1839




      <210> 48
      <211> 2981
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (158)..(1999)

      <220>
      <221> misc_feature
      <222> (1)...(2981)
      <223> n = a,t,c or g

      <400> 48
 ccacgcgtcc gttcggcagc tccagttcag ctcgctcggc gcacccacgc ctcgctgccc     60

 cgcttcctgc cctcaacctg ggcatgcgcc ccccaccctt ccggcccccc agaacccgcg    120

 ccatcccccg gagcctcccc agagctggcc gcgcagg atg ggc gcc ctc agg ccc     175
                                          Met Gly Ala Leu Arg Pro
                                            1               5

 acg ctg ctg ccg cct tcg ctg ccg ctg ctg ctg ctg cta atg cta gga      223
 Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu Leu Leu Leu Met Leu Gly
              10                  15                  20

 atg gga tgc tgg gcc cgg gag gtg ctg gtc ccc gag ggg ccc ttg tac      271
 Met Gly Cys Trp Ala Arg Glu Val Leu Val Pro Glu Gly Pro Leu Tyr
          25                  30                  35

 cgc gtg gct ggc aca gct gtc tcc atc tcc tgc aat gtg acc ggc tat      319
 Arg Val Ala Gly Thr Ala Val Ser Ile Ser Cys Asn Val Thr Gly Tyr
      40                  45                  50

 gag ggc cct gcc cag cag aac ttc gag tgg ttc ctg tat agg ccc gag      367
 Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp Phe Leu Tyr Arg Pro Glu
  55                  60                  65                  70

 gcc cca gat act gca ctg ggc att gtc agt acc aag gat acc cag ttc      415
 Ala Pro Asp Thr Ala Leu Gly Ile Val Ser Thr Lys Asp Thr Gln Phe
                  75                  80                  85

 tcc tat gct gtc ttc aag tcc cga gtg gtg gcg ggt gag gtg cag gtg      463
 Ser Tyr Ala Val Phe Lys Ser Arg Val Val Ala Gly Glu Val Gln Val
              90                  95                 100

 cag cgc cta caa ggt gat gcc gtg gtg ctc aag att gcc cgc ctg cag      511
 Gln Arg Leu Gln Gly Asp Ala Val Val Leu Lys Ile Ala Arg Leu Gln
         105                 110                 115

 gcc cag gat gcc ggc att tat gag tgc cac acc ccc tcc act gat acc      559
 Ala Gln Asp Ala Gly Ile Tyr Glu Cys His Thr Pro Ser Thr Asp Thr
     120                 125                 130

 cgc tac ctg ggc agc tac agc ggc aag gtg gag ctg aga gtt ctt cca      607
 Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val Glu Leu Arg Val Leu Pro
 135                 140                 145                 150

 gat gtc ctc cag gtg tct gct gcc ccc cca ggg ccc cga ggc cgc cag      655
 Asp Val Leu Gln Val Ser Ala Ala Pro Pro Gly Pro Arg Gly Arg Gln
                 155                 160                 165

 gcc cca acc tca ccc cca cgc atg acg gtg cat gag ggg cag gag ctg      703
 Ala Pro Thr Ser Pro Pro Arg Met Thr Val His Glu Gly Gln Glu Leu
             170                 175                 180

 gca ctg ggc tgc ctg gcg agg aca agc aca cag aag cac aca cac ctg      751
 Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr Gln Lys His Thr His Leu
         185                 190                 195

 gca gtg tcc ttt ggg cga tct gtg ccc gag gca cca gtt ggg cgg tca      799
 Ala Val Ser Phe Gly Arg Ser Val Pro Glu Ala Pro Val Gly Arg Ser
     200                 205                 210

 act ctg cag gaa gtg gtg gga atc cgg tca gac ttg gcc gtg gag gct      847
 Thr Leu Gln Glu Val Val Gly Ile Arg Ser Asp Leu Ala Val Glu Ala
 215                 220                 225                 230

 gga gct ccc tat gct gag cga ttg gct gca ggg gag ctt cgt ctg ggc      895
 Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala Gly Glu Leu Arg Leu Gly
                 235                 240                 245

 aag gaa ggg acc gat cgg tac cgc atg gta gta ggg ggt gcc cag gca      943
 Lys Glu Gly Thr Asp Arg Tyr Arg Met Val Val Gly Gly Ala Gln Ala
             250                 255                 260

 ggg gac gca ggc acc tac cac tgc act gcc gct gag tgg att cag gat      991
 Gly Asp Ala Gly Thr Tyr His Cys Thr Ala Ala Glu Trp Ile Gln Asp
         265                 270                 275

 cct gat ggc agc tgg gcc cag att gca gag aaa agg gcc gtc ctg gcc     1039
 Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu Lys Arg Ala Val Leu Ala
     280                 285                 290

 cac gtg gat gtg cag acg ctg tcc agc cag ctg gca gtg aca gtg ggg     1087
 His Val Asp Val Gln Thr Leu Ser Ser Gln Leu Ala Val Thr Val Gly
 295                 300                 305                 310

 cct ggt gaa cgt cgg atc ggc cca ggg gag ccc ttg gaa ctg ctg tgc     1135
 Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu Pro Leu Glu Leu Leu Cys
                 315                 320                 325

 aat gtg tca ggg gca ctt ccc cca gca ggc cgt cat gct gca tac tct     1183
 Asn Val Ser Gly Ala Leu Pro Pro Ala Gly Arg His Ala Ala Tyr Ser
             330                 335                 340

 gta ggt tgg gag atg gca cct gcg ggg gca cct ggg ccc ggc cgc ctg     1231
 Val Gly Trp Glu Met Ala Pro Ala Gly Ala Pro Gly Pro Gly Arg Leu
         345                 350                 355

 gta gcc cag ctg gac aca gag ggt gtg ggc agc ctg ggc cct ggc tat     1279
 Val Ala Gln Leu Asp Thr Glu Gly Val Gly Ser Leu Gly Pro Gly Tyr
     360                 365                 370

 gag ggc cga cac att gcc atg gag aag gtg gca tcc aga aca tac cgg     1327
 Glu Gly Arg His Ile Ala Met Glu Lys Val Ala Ser Arg Thr Tyr Arg
 375                 380                 385                 390

 cta cgg cta gag gct gcc agg cct ggt gat gcg ggc acc tac cgc tgc     1375
 Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp Ala Gly Thr Tyr Arg Cys
                 395                 400                 405

 ctc gcc aaa gcc tat gtt cga ggg tct ggg acc cgg ctt cgt gaa gca     1423
 Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly Thr Arg Leu Arg Glu Ala
             410                 415                 420

 gcc agt gcc cgt tcc cgg cct ctc cct gta cat gtg cgg gag gaa ggt     1471
 Ala Ser Ala Arg Ser Arg Pro Leu Pro Val His Val Arg Glu Glu Gly
         425                 430                 435

 gtg gtg ctg gag gct gtg gca tgg cta gca gga ggc aca gtg tac cgc     1519
 Val Val Leu Glu Ala Val Ala Trp Leu Ala Gly Gly Thr Val Tyr Arg
     440                 445                 450

 ggg gag act gcc tcc ctg ctg tgc aac atc tct gtg cgg ggt ggc ccc     1567
 Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile Ser Val Arg Gly Gly Pro
 455                 460                 465                 470

 cca gga ctg cgg ctg gcc gcc agc tgg tgg gtg gag cga cca gag gac     1615
 Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp Val Glu Arg Pro Glu Asp
                 475                 480                 485

 gga gag ctc agc tct gtc cct gcc cag ctg gtg ggt ggc gta ggc cag     1663
 Gly Glu Leu Ser Ser Val Pro Ala Gln Leu Val Gly Gly Val Gly Gln
             490                 495                 500

 gat ggt gtg gca gag ctg gga gtc cgg cct gga gga ggc cct gtc agc     1711
 Asp Gly Val Ala Glu Leu Gly Val Arg Pro Gly Gly Gly Pro Val Ser
         505                 510                 515

 gta gag ctg gtg ggg ccc cga agc cat cgg ctg aga cta cac agc ttg     1759
 Val Glu Leu Val Gly Pro Arg Ser His Arg Leu Arg Leu His Ser Leu
     520                 525                 530

 ggg ccc gag gat gaa ggc gtg tac cac tgt gcc ccc agc gcc tgg gtg     1807
 Gly Pro Glu Asp Glu Gly Val Tyr His Cys Ala Pro Ser Ala Trp Val
 535                 540                 545                 550

 cag cat gcc gac tac agc tgg tac cag gcg ggc agt gcc cgc tca ggg     1855
 Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala Gly Ser Ala Arg Ser Gly
                 555                 560                 565

 cct gtt aca gtc tac ccc tac atg cat gcc ctg gac acc cta ttt gtg     1903
 Pro Val Thr Val Tyr Pro Tyr Met His Ala Leu Asp Thr Leu Phe Val
             570                 575                 580

 cct ctg ctg gtg ggt aca ggg gtg gcc cta gtc act ggt gcc act gtc     1951
 Pro Leu Leu Val Gly Thr Gly Val Ala Leu Val Thr Gly Ala Thr Val
         585                 590                 595

 ctt ggt acc atc act tgc tgc ttc atg aag agg ctt cga aaa cgg tga     1999
 Leu Gly Thr Ile Thr Cys Cys Phe Met Lys Arg Leu Arg Lys Arg 
     600                 605                 610

 tcccttactc cccaggtctt gcaggtgtcg actgtcttcc ggcccagctc caagccctcc   2059

 tctggttgcc tggacaccct ctccctctgt ccactcttcc tttaatttat ttgacctccc   2119

 actacccaga atgggagacg tgcctcccct tccccactcc ttccctccca agcccctccc   2179

 tctggccttc tgttcttgat ctcttaggga tcctataggg aggccatttc ctgtcctgga   2239

 attagttttt ctaaaatgtg aataaacttg ttttataaaa aaaaaaaaaa aaaaaaaaaa   2299

 aaaaacccgc ccctttgatt taaagggccc cttaaaaccc cgtggaaaac cccggagggc   2359

 ccttttaagg gccccccctt ttgttgttgc cccccccccc ggcctttttt tgccctggga   2419

 ggggccccct ccccttgctt tttttaaaaa aaagaagaaa ttgcccccaa tttgtgggag   2479

 aagggtgctt tctattggtg gtaccaggcg ggcagtgccc gctcagggcc tgttacagtc   2539

 tacccctaca tgcatgccct ggacacccta tttgtgcctc tgctggtggg tacaggggtg   2599

 gccctagtca ctggtgccac tgtccttggt accatcactt gctgcttcat gaaaaggctt   2659

 cgaaaacggt gatcccttac tccccagccc acaccgggca cccttttcag gtcttgcagg   2719

 tgtcgactgt cttccggccc agctccaagc cctcctctgg ttgcctggac accctctccc   2779

 tctgtccact cttcctttaa tttatttgac ctcccacnac ccagaatggg agacgtgcct   2839

 ccccttcccc actccttccc tcccaagccc ctccctctgg ccttctgttc ttgatctctt   2899

 agggatccta tagggaggcc atttcctgtc ctggaattag tttttctaaa atgtgaataa   2959

 acttgtttta taaaaaaaaa aa                                            2981




      <210> 49
      <211> 2112
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (148)..(1077)

      <400> 49
 attcggcagc tccagttcag ctcgctcggc gcacccacgc ctcgctgccc cgcttcctgc     60

 cctcaacctg ggcatgcgcc ccccaccctt ccggcccccc agaacccgcg ccatcccccg    120

 gagcctcccc agagctggcc gcgcagg    atg ggc gcc ctc agg ccc acg ctg     171
                                  Met Gly Ala Leu Arg Pro Thr Leu
                                    1               5

 ctg ccg cct tcg ctg ccg ctg ctg ctg ctg cta atg cta gga atg gga      219
 Leu Pro Pro Ser Leu Pro Leu Leu Leu Leu Leu Met Leu Gly Met Gly
      10                  15                  20

 tgc tgg gcc cgg gag gtg ctg gtc ccc gag ggg ccc ttg tac cgc gtg      267
 Cys Trp Ala Arg Glu Val Leu Val Pro Glu Gly Pro Leu Tyr Arg Val
  25                  30                  35                  40

 gct ggc aca gct gtc tcc atc tcc tgc aat gtg acc ggc tat gag ggc      315
 Ala Gly Thr Ala Val Ser Ile Ser Cys Asn Val Thr Gly Tyr Glu Gly
                  45                  50                  55

 cct gcc cag cag aac ttc gag tgg ttc ctg tat agg ccc gag gcc cca      363
 Pro Ala Gln Gln Asn Phe Glu Trp Phe Leu Tyr Arg Pro Glu Ala Pro
              60                  65                  70

 gat act gca ctg ggc att gtc agt acc aag gat acc cag ttc tcc tat      411
 Asp Thr Ala Leu Gly Ile Val Ser Thr Lys Asp Thr Gln Phe Ser Tyr
          75                  80                  85

 gct gtc ttc aag tcc cga gtg gtg gcg ggt gag gtg cag gtg cag cgc      459
 Ala Val Phe Lys Ser Arg Val Val Ala Gly Glu Val Gln Val Gln Arg
      90                  95                 100

 cta caa ggt gat gcc gtg gtg ctc aag att gcc cgc ctg cag gcc cag      507
 Leu Gln Gly Asp Ala Val Val Leu Lys Ile Ala Arg Leu Gln Ala Gln
 105                 110                 115                 120

 gat gcc ggc att tat gag tgc cac acc ccc tcc act gat acc cgc tac      555
 Asp Ala Gly Ile Tyr Glu Cys His Thr Pro Ser Thr Asp Thr Arg Tyr
                 125                 130                 135

 ctg ggc agc tac agc ggc aag gtg gag ctg aga gtt ctc cca gat gtc      603
 Leu Gly Ser Tyr Ser Gly Lys Val Glu Leu Arg Val Leu Pro Asp Val
             140                 145                 150

 ctc cag gtg tct gct gcc ccc cca ggg ccc cga ggc cgc cag gcc cca      651
 Leu Gln Val Ser Ala Ala Pro Pro Gly Pro Arg Gly Arg Gln Ala Pro
         155                 160                 165

 acc tca ccc cca cgc atg acg gtg cat gag ggg cag gag ctg gca ctg      699
 Thr Ser Pro Pro Arg Met Thr Val His Glu Gly Gln Glu Leu Ala Leu
     170                 175                 180

 ggc tgc ctg gcg agg aca agc aca cag aag cac aca cac ctg gca gtg      747
 Gly Cys Leu Ala Arg Thr Ser Thr Gln Lys His Thr His Leu Ala Val
 185                 190                 195                 200

 tcc ttt ggg cga tct gtg ccc gag gca cca gtt ggg cgg tca act ctg      795
 Ser Phe Gly Arg Ser Val Pro Glu Ala Pro Val Gly Arg Ser Thr Leu
                 205                 210                 215

 cag gaa gtg gtg gga atc cgg tca gac ttg gcc gtg gag gct gga gct      843
 Gln Glu Val Val Gly Ile Arg Ser Asp Leu Ala Val Glu Ala Gly Ala
             220                 225                 230

 ccc tat gct gag cga ttg gct gca ggg gag ctt cgt ctg ggc aag gaa      891
 Pro Tyr Ala Glu Arg Leu Ala Ala Gly Glu Leu Arg Leu Gly Lys Glu
         235                 240                 245

 ggg acc gat cgg ccc agg gga gcc ctt gga act gct gtg caa tgt gtc      939
 Gly Thr Asp Arg Pro Arg Gly Ala Leu Gly Thr Ala Val Gln Cys Val
     250                 255                 260

 agg ggc act tcc ccc agc agg ccg tca tgc tgc ata ctc tgt agg ttg      987
 Arg Gly Thr Ser Pro Ser Arg Pro Ser Cys Cys Ile Leu Cys Arg Leu
 265                 270                 275                 280

 gga gat ggc acc tgc ggg ggc acc tgg gcc cgg ccg cct ggt agc cca     1035
 Gly Asp Gly Thr Cys Gly Gly Thr Trp Ala Arg Pro Pro Gly Ser Pro
                 285                 290                 295

 gct gga cac aga ggg tgt ggg cag cct ggg ccc tgg cta tga gggccga     1084
 Ala Gly His Arg Gly Cys Gly Gln Pro Gly Pro Trp Leu 
             300                 305

 cacattgcca tggagaaggt ggcatccaga acataccggc tacggctaga ggctgccagg   1144

 cctggtgatg cgggcaccta ccgctgcctc gccaaagcct atgttcgagg gtctgggacc   1204

 cggcttcgtg aagcagccag tgcccgttcc cggcctctcc ctgtacacgt gcgggaggaa   1264

 ggtgtggtgc tggaagctgt ggcatggcta gcaggaggca cagtgtaccg cggggagact   1324

 gcctccctgc tgtgcaacat ctctgtgcgg ggtggccccc caggactgcg gctggccgcc   1384

 agctggtggg tggagcgacc agaggatgga gagctcagct ctgtccctgc ccagctggtg   1444

 ggtggcgtag gccaggatgg tgtggcagag ctgggagtcc ggcctggagg aggccctgtc   1504

 agcgtagagc tggtggggcc ccgaagccat cggctgagac tacacagctt ggggcccgag   1564

 gatgaaggcg tgtaccactg tgcccccagc gcctgggtgc agcatgccga ctacagctgg   1624

 taccaggcgg gcagtgcccg ctcagggcct gttacagtct acccctacat gcatgccctg   1684

 gacaccctat ttgtgcctct gctggtgggt acaggggtgg ccctagtcac tggtgccact   1744

 gtccttggta ccatcacttg ctgcttcatg aagaggcttc gaaaacggtg atcccttact   1804

 ccccagccca caccgggcac ccttttcagg tcttgcaggt gtcgactgtc ttccggccca   1864

 gctccaagcc ctcctctggt tgcctggaca ccctctccct ctgtccactc ttcctttaat   1924

 ttatttgacc tcccactacc cagaatggga gacgtgcctc cccttcccca ctccttccct   1984

 cccaagcccc tccctctggc cttctgttct tgatctctta gggatcctat agggaggcca   2044

 tttcctgtcc tggaattagt ttttctaaaa tgtgaataaa cttgttttat aaaaagcaaa   2104

 aaaaaaaa                                                            2112




      <210> 50
      <211> 752
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (49)..(639)

      <400> 50
 cagaacccgc gccatccccc ggagcctccc cagagctggc cgcgcagg atg ggc gcc      57
                                                      Met Gly Ala
                                                        1

 ctc agg ccc acg ctg ctg ccg cct tcg ctg ccg ctg ctg ctg ctg cta      105
 Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu Leu Leu Leu
       5                  10                  15

 atg cta gga atg gga tgc tgg gcc cgg gag gtg ctg gtc ccc gag ggg      153
 Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val Pro Glu Gly
  20                  25                  30                  35

 ccc ttg tac cgc gtg gct ggc aca gct gtc tcc atc tcc tgc aat gtg      201
 Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser Cys Asn Val
                  40                  45                  50

 acc ggc tat gag ggc cct gcc cag cag aac ttc gag tgg ttc ctg tat      249
 Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp Phe Leu Tyr
              55                  60                  65

 agg ccc gag gcc cca gat act gca ctg ggc att gtc agt acc aag gat      297
 Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser Thr Lys Asp
          70                  75                  80

 acc cag ttc tcc tat gct gag cga ttg gct gca ggg gag ctt cgt ctg      345
 Thr Gln Phe Ser Tyr Ala Glu Arg Leu Ala Ala Gly Glu Leu Arg Leu
      85                  90                  95

 ggc aag gaa ggg acc gat cgg tac cgc atg gta gta ggg ggt gcc cag      393
 Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val Val Gly Gly Ala Gln
 100                 105                 110                 115

 gca ggg gac gca ggc acc tac cac tgc act gcc gct gag tgg att cag      441
 Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala Ala Glu Trp Ile Gln
                 120                 125                 130

 gat cct gat ggc agc tgg gcc cag att gca gag aaa agg gcc gtc ctg      489
 Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu Lys Arg Ala Val Leu
             135                 140                 145

 gcc cac gtg gat gtg cag acg ctg tgt aag tgc cac tta tac atc cca      537
 Ala His Val Asp Val Gln Thr Leu Cys Lys Cys His Leu Tyr Ile Pro
         150                 155                 160

 ctg tgg gag ctg gga ggg aca gta tcc tgg tgg gca ctg tgg cca cag      585
 Leu Trp Glu Leu Gly Gly Thr Val Ser Trp Trp Ala Leu Trp Pro Gln
     165                 170                 175

 ggg gta cca gat agc cat cat ctg act cca agg aac tca tct tcc aca      633
 Gly Val Pro Asp Ser His His Leu Thr Pro Arg Asn Ser Ser Ser Thr
 180                 185                 190                 195

 gag tga gcagccttgc tagcatttct ctcccccggc ccttgatggg ttttctctgc       689
 Glu 


 tcagaaattg ggtatagaga taggaggccc atgctgaggg gtgagattca agcccctaaa    749

 tag                                                                  752




      <210> 51
      <211> 2710
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(1135)

      <400> 51
 tactctcggg acctggggtg ggggtgcggt gacacctgtg ggcacagccc taggggacct     60

 ctttctcctg gacattgaag atatggccct ttggaggtga cccaggagag aaggg atg     118
                                                              Met
                                                                1

 aag gcc ttt ggt cct cca cat gag ggc ccc ctc caa gga ctc gtg gcc      166
 Lys Ala Phe Gly Pro Pro His Glu Gly Pro Leu Gln Gly Leu Val Ala
               5                  10                  15

 tcc cgc att gag act tat ggg ggc cgg cat cga gcc tct gct cag agc      214
 Ser Arg Ile Glu Thr Tyr Gly Gly Arg His Arg Ala Ser Ala Gln Ser
          20                  25                  30

 act act ggc aga ctc tat ccc cga gga tac cct gtg ctg gat ccc agt      262
 Thr Thr Gly Arg Leu Tyr Pro Arg Gly Tyr Pro Val Leu Asp Pro Ser
      35                  40                  45

 cgc cga cgc ctc cag cag tat gtc ccc ttt gcc agg ggt tct ggc cag      310
 Arg Arg Arg Leu Gln Gln Tyr Val Pro Phe Ala Arg Gly Ser Gly Gln
  50                  55                  60                  65

 gcc cga ggc ctg tca ccc atg aga ctg cga gat cca gag ccc gag aag      358
 Ala Arg Gly Leu Ser Pro Met Arg Leu Arg Asp Pro Glu Pro Glu Lys
                  70                  75                  80

 agg cac ggg ggc cat gtg ggg gct ggc ctg ctt cac tcc ccc aaa ctc      406
 Arg His Gly Gly His Val Gly Ala Gly Leu Leu His Ser Pro Lys Leu
              85                  90                  95

 aag gaa ctc acc aag gcc cat gag ctg gag gtg agg ctg cac act ttc      454
 Lys Glu Leu Thr Lys Ala His Glu Leu Glu Val Arg Leu His Thr Phe
         100                 105                 110

 agc atg ttt ggg atg ccc cgg ctg ccc cct gag gac cgg cgg cac tgg      502
 Ser Met Phe Gly Met Pro Arg Leu Pro Pro Glu Asp Arg Arg His Trp
     115                 120                 125

 gag ata gga gag ggt ggc gac agt ggc ctg acc atc gag aag tcc tgg      550
 Glu Ile Gly Glu Gly Gly Asp Ser Gly Leu Thr Ile Glu Lys Ser Trp
 130                 135                 140                 145

 agg gag ctg gtg cct ggg cac aag gag atg agc cag gag ctc tgc cac      598
 Arg Glu Leu Val Pro Gly His Lys Glu Met Ser Gln Glu Leu Cys His
                 150                 155                 160

 caa cag gag gcc ctg tgg gag ctc ctg acc acc gag ctg atc tac gtg      646
 Gln Gln Glu Ala Leu Trp Glu Leu Leu Thr Thr Glu Leu Ile Tyr Val
             165                 170                 175

 aga aag ctc aag atc atg act gat ctg cta gcc gcc ggc ctg ctg aac      694
 Arg Lys Leu Lys Ile Met Thr Asp Leu Leu Ala Ala Gly Leu Leu Asn
         180                 185                 190

 ctg cag cga gtg gga ctg ctg atg gaa gtg tca gct gag acc ctg ttt      742
 Leu Gln Arg Val Gly Leu Leu Met Glu Val Ser Ala Glu Thr Leu Phe
     195                 200                 205

 gga aat gtc ccc agc ctg att cga acc cac cgg agc ttt tgg gat gag      790
 Gly Asn Val Pro Ser Leu Ile Arg Thr His Arg Ser Phe Trp Asp Glu
 210                 215                 220                 225

 gtg ctg ggg ccc acc ctg gag gag act cgg gcc tcg ggc cag cct ctg      838
 Val Leu Gly Pro Thr Leu Glu Glu Thr Arg Ala Ser Gly Gln Pro Leu
                 230                 235                 240

 gac ccc att ggt ctg caa agt ggc ttc ctg acg ttt ggc cag cgg ttc      886
 Asp Pro Ile Gly Leu Gln Ser Gly Phe Leu Thr Phe Gly Gln Arg Phe
             245                 250                 255

 cac ccc tat gtc cag tac tgc ctc cga gtg aag cag acc atg gct tac      934
 His Pro Tyr Val Gln Tyr Cys Leu Arg Val Lys Gln Thr Met Ala Tyr
         260                 265                 270

 gcc cga gaa cag caa gaa act aac cct ctc ttc cat gcc ttc gtg cag      982
 Ala Arg Glu Gln Gln Glu Thr Asn Pro Leu Phe His Ala Phe Val Gln
     275                 280                 285

 tgg tgt gag aag cac aag cgc tct ggg agg cag atg ctc tgt gac ttg     1030
 Trp Cys Glu Lys His Lys Arg Ser Gly Arg Gln Met Leu Cys Asp Leu
 290                 295                 300                 305

 ctt atc aag ccc cac cag cgc atc acc aag tac cca ctg ctg ctc cat     1078
 Leu Ile Lys Pro His Gln Arg Ile Thr Lys Tyr Pro Leu Leu Leu His
                 310                 315                 320

 gct gtg ctc aag agg agc ccc gag gca cga gcc caa gag gcc ctg aat     1126
 Ala Val Leu Lys Arg Ser Pro Glu Ala Arg Ala Gln Glu Ala Leu Asn
             325                 330                 335

 gcc att tga agccgtg gagtcattcc tgcgacatat caatgggcag gtccgccagg     1182
 Ala Ile 


 gcgaagagca agagagcttg gcggctgcag cacaacgcat cgggccctac gaggtgctgg   1242

 agccacccag tgatgaggtg gagaagaacc tgcgcccatt ctccaccctg gacctgacgt   1302

 cccccatgct gggggttgca tctgagcaca ccagacagct gctgctggag gggcctgtgc   1362

 gagtgaagga gggacgagaa gggaagctgg acgtgtacct gttcctcttc tctgatgtgc   1422

 tccttgtgac caagccccag cgcaaggcgg acaaagccaa ggtcatccga ccccctctca   1482

 tgctggagaa gctcgtgtgc caacccctgc gagaccccaa cagcttcctg ctgatccacc   1542

 tcactgaatt ccagtgtgtc tccagcgccc tccttgtgca ctgtcccagt cctacagacc   1602

 gtgcccagtg gctggagaag acccagcagg cccaggccgc cctacagaag ctgaaggcag   1662

 aggagtatgt tcaacagaag agggagctcc tgaccctcta tcgggaccag gacagggagt   1722

 cccccagcac caggccctcc acgccttccc tggagggctc tcagagcagc gcagagggga   1782

 ggactcctga gttctcgacc attatccccc acctggtggt gacagaagac acagatgaag   1842

 atgctcccct tgtgccagat gatacctcag actctggcta cggcactttg atcccaggca   1902

 cccccacggg gtcccgctcc ccactgagcc gtctacgcca aagagccctt cggcgggacc   1962

 ctcgcctcac cttctccacc ctggaactcc gggacatccc tctgcgtccc caccctcccg   2022

 acccccaagc tcctcaacgc cgaagcgccc ccgaactgcc ggaaggaatc ctaaaaggag   2082

 gcagtcttcc ccaggaagac ccaccaacct ggtctgagga agaagatggg gcctccgagc   2142

 gagggaatgt ggtggtggaa acactccaca gggcccggct tcggggccag cttccctcct   2202

 ccccaaccca tgctgactct gccggggaaa gcccctggga gtcctcaggg gaggaggaag   2262

 aagaggggcc tctgttcctg aaagctggcc acacatccct gcgcccaatg cgggctgagg   2322

 acatgctcag agagatccgg gaggagctgg ccagccaaag gattgagggg gccgaggagc   2382

 cccgggacag caggccacgg aagctgactc gggcccagct gcagaggatg cgggggcccc   2442

 acatcattca gctggacacc cctctgtccg catcagaggt atgaggaatg cagaggacct   2502

 ttggcatgca tctctcccag aggagatctc tccccagtag tgctggtcac cctccggcat   2562

 ctgtgactct acctcaagga ccacatttcc caaaggaagc ctggcccagg caccctgcct   2622

 cctgctctgt ttggggatca agaactgtaa atttatgtat cataggtgca cctgagcccc   2682

 acagaaagtt gtgcataaaa atgactgc                                      2710




      <210> 52
      <211> 2737
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2007)

      <400> 52
  atg aca tgc cct ccc aca ggc ctg tat ggc ccc gag ggc atc cta cct      48
  Met Thr Cys Pro Pro Thr Gly Leu Tyr Gly Pro Glu Gly Ile Leu Pro
    1               5                  10                  15

 gca agg agg acg ctg cgg cct cag ggc aag ggg cgc tgg cag cag ctg       96
 Ala Arg Arg Thr Leu Arg Pro Gln Gly Lys Gly Arg Trp Gln Gln Leu
              20                  25                  30

 tgg gag acc ccg acg ctg ctg tgg gaa gcg ccg aga ctg ggg ctg gac      144
 Trp Glu Thr Pro Thr Leu Leu Trp Glu Ala Pro Arg Leu Gly Leu Asp
          35                  40                  45

 acg gcc cag ggc ctg gag ctg ctg agc ctg ctg ggt gca cta gtg gcc      192
 Thr Ala Gln Gly Leu Glu Leu Leu Ser Leu Leu Gly Ala Leu Val Ala
      50                  55                  60

 ctg gga gcc ctg ctg ctg agc cca ctg cgc cac cct gtc atc tac ttg      240
 Leu Gly Ala Leu Leu Leu Ser Pro Leu Arg His Pro Val Ile Tyr Leu
  65                  70                  75                  80

 ctg ctt tgg gcc gcc tac ctg gac tcc ctg ctg cta gag act ggc ttc      288
 Leu Leu Trp Ala Ala Tyr Leu Asp Ser Leu Leu Leu Glu Thr Gly Phe
                  85                  90                  95

 ctg gcc gtg ctg gtg gcc ccg ctg agg cca gcc tcc cac cgc aag gag      336
 Leu Ala Val Leu Val Ala Pro Leu Arg Pro Ala Ser His Arg Lys Glu
             100                 105                 110

 gcc ccc cag ggc agg cag gca ggg gcc ctg ccc cac gaa gac ctc ccc      384
 Ala Pro Gln Gly Arg Gln Ala Gly Ala Leu Pro His Glu Asp Leu Pro
         115                 120                 125

 ttc tgg ctg gtg cga tgg ctg ctg ttc cgc ctc atg ttc gcc tca ggc      432
 Phe Trp Leu Val Arg Trp Leu Leu Phe Arg Leu Met Phe Ala Ser Gly
     130                 135                 140

 gtg gtc aag ctg acc agc cgc tgc cct gcg tgg tgg ggg ctc act gcc      480
 Val Val Lys Leu Thr Ser Arg Cys Pro Ala Trp Trp Gly Leu Thr Ala
 145                 150                 155                 160

 ctc acc tac cac tac gag acc cag tgc ctg ccc acg ccc gcc gcc tgg      528
 Leu Thr Tyr His Tyr Glu Thr Gln Cys Leu Pro Thr Pro Ala Ala Trp
                 165                 170                 175

 ttc gca cac cac ctg ccg gtc tgg ctg cac aag ctc agc gtg gtg gcc      576
 Phe Ala His His Leu Pro Val Trp Leu His Lys Leu Ser Val Val Ala
             180                 185                 190

 acc ttc cta att gag atc gct gtg ccg ccc ctg ttc ttc gcc ccc att      624
 Thr Phe Leu Ile Glu Ile Ala Val Pro Pro Leu Phe Phe Ala Pro Ile
         195                 200                 205

 cga cgc ctg cgc ttg gct gct ttc tac tcg cag gtg ctg ctg cag gtc      672
 Arg Arg Leu Arg Leu Ala Ala Phe Tyr Ser Gln Val Leu Leu Gln Val
     210                 215                 220

 ctg att atc atc acc ggc aac tac aac ttc ttc aac ctg atg acg ctg      720
 Leu Ile Ile Ile Thr Gly Asn Tyr Asn Phe Phe Asn Leu Met Thr Leu
 225                 230                 235                 240

 gtg ctt acc act gcg ctg ctg gac gac cag cac ctg gct gct gag cct      768
 Val Leu Thr Thr Ala Leu Leu Asp Asp Gln His Leu Ala Ala Glu Pro
                 245                 250                 255

 ggc cac ggc agc cgc aag aag acg gcc acc tcc tgg ccc aag gcc ctg      816
 Gly His Gly Ser Arg Lys Lys Thr Ala Thr Ser Trp Pro Lys Ala Leu
             260                 265                 270

 ctg gcc acc ctg tcg ctg ctg ctg gaa cta gcc gtc tac ggg ctt ctg      864
 Leu Ala Thr Leu Ser Leu Leu Leu Glu Leu Ala Val Tyr Gly Leu Leu
         275                 280                 285

 gcc tat ggc act gtg cac tac ttt ggc ctg gag gtt gac tgg cag cag      912
 Ala Tyr Gly Thr Val His Tyr Phe Gly Leu Glu Val Asp Trp Gln Gln
     290                 295                 300

 cgc acc atc cac tcc aga acc act ttc acc ttc cac cag ttt tct cag      960
 Arg Thr Ile His Ser Arg Thr Thr Phe Thr Phe His Gln Phe Ser Gln
 305                 310                 315                 320

 tgg ctg aag aca ctg acg ctg ccc act gtg tgg ctg ggt gtg gcc tcc     1008
 Trp Leu Lys Thr Leu Thr Leu Pro Thr Val Trp Leu Gly Val Ala Ser
                 325                 330                 335

 ctg gtc tgg gag ctg ctg agt gcc ctg tgg agg tgg acc cag gtg cgg     1056
 Leu Val Trp Glu Leu Leu Ser Ala Leu Trp Arg Trp Thr Gln Val Arg
             340                 345                 350

 ggc tgg cta cgg aag ctc agt gct gta gtc caa ctg tcc ctt gtg ggc     1104
 Gly Trp Leu Arg Lys Leu Ser Ala Val Val Gln Leu Ser Leu Val Gly
         355                 360                 365

 act gcg acc gtg gcc ttg ttc ctg att agc ctg gtg ccg tac tcc tac     1152
 Thr Ala Thr Val Ala Leu Phe Leu Ile Ser Leu Val Pro Tyr Ser Tyr
     370                 375                 380

 gtg gag ccc ggg acc cac ggg cgc ctc tgg acc ggg gcc cac cgc ctg     1200
 Val Glu Pro Gly Thr His Gly Arg Leu Trp Thr Gly Ala His Arg Leu
 385                 390                 395                 400

 ttt ggt gcc gtg gag cac cta cag ctg gcc aac tcc tac ggc ctc ttc     1248
 Phe Gly Ala Val Glu His Leu Gln Leu Ala Asn Ser Tyr Gly Leu Phe
                 405                 410                 415

 cgc cgc atg act ggg ctt ggt gga cgg cct gag gtg gtg ctg gag ggc     1296
 Arg Arg Met Thr Gly Leu Gly Gly Arg Pro Glu Val Val Leu Glu Gly
             420                 425                 430

 agt tac gac ggc cac cac tgg acg gag atc gag ttc atg tac aag cct     1344
 Ser Tyr Asp Gly His His Trp Thr Glu Ile Glu Phe Met Tyr Lys Pro
         435                 440                 445

 ggg aac ctg agc cgg ccg ccc ccg gtt gtg gtg ccc cac cag cca cgc     1392
 Gly Asn Leu Ser Arg Pro Pro Pro Val Val Val Pro His Gln Pro Arg
     450                 455                 460

 ctg gac tgg cag atg tgg ttt gca gcc ctg ggc cca cac acg cac agc     1440
 Leu Asp Trp Gln Met Trp Phe Ala Ala Leu Gly Pro His Thr His Ser
 465                 470                 475                 480

 ccg tgg ttc aca agc ctg gtc ttg cgc ctg ctg cag ggc aag gag cca     1488
 Pro Trp Phe Thr Ser Leu Val Leu Arg Leu Leu Gln Gly Lys Glu Pro
                 485                 490                 495

 gtg atc cgc ctt gtc cag agc caa gtg gcc agg tat ccc ttc cac aag     1536
 Val Ile Arg Leu Val Gln Ser Gln Val Ala Arg Tyr Pro Phe His Lys
             500                 505                 510

 cag ccg ccc acc tac gtc cga gcc cag cgc tac aag tac tgg ttc tcc     1584
 Gln Pro Pro Thr Tyr Val Arg Ala Gln Arg Tyr Lys Tyr Trp Phe Ser
         515                 520                 525

 cag cct ggg gag cag ggc cag tgg tgg cgg cgc cag tgg gtg gag gag     1632
 Gln Pro Gly Glu Gln Gly Gln Trp Trp Arg Arg Gln Trp Val Glu Glu
     530                 535                 540

 ttc ttc cca tcc gtg tcc ctg ggg gac ccc acg ctg gag acg ctg ctc     1680
 Phe Phe Pro Ser Val Ser Leu Gly Asp Pro Thr Leu Glu Thr Leu Leu
 545                 550                 555                 560

 agg cag ttt gga cta cag gag aaa agc cca cct cgc acc cgc agc gcc     1728
 Arg Gln Phe Gly Leu Gln Glu Lys Ser Pro Pro Arg Thr Arg Ser Ala
                 565                 570                 575

 aac agc acc ctg gcc cag gcc ctc cac tgg act cgc tct cag ctg tct     1776
 Asn Ser Thr Leu Ala Gln Ala Leu His Trp Thr Arg Ser Gln Leu Ser
             580                 585                 590

 ccc ctg gag gcc ccc gcc ctg ctc tgg ggg ctc ctc atg gcc gtg ggg     1824
 Pro Leu Glu Ala Pro Ala Leu Leu Trp Gly Leu Leu Met Ala Val Gly
         595                 600                 605

 gct gtc aga ttt gtg cag gcc ctg cta gca ccc tgt tct ctc cgg tcc     1872
 Ala Val Arg Phe Val Gln Ala Leu Leu Ala Pro Cys Ser Leu Arg Ser
     610                 615                 620

 tcc ccg ctg gca cca gtc agc ggg gag aag cgc agg cca gcc tcc cag     1920
 Ser Pro Leu Ala Pro Val Ser Gly Glu Lys Arg Arg Pro Ala Ser Gln
 625                 630                 635                 640

 aaa gac tcc gga gct gcc tcc gaa cag gcc acc gca gcc ccc aac ccc     1968
 Lys Asp Ser Gly Ala Ala Ser Glu Gln Ala Thr Ala Ala Pro Asn Pro
                 645                 650                 655

 tgc tcc agt agt tcg agg acc acc cgg cga aag aag tag ctgtgttctc      2017
 Cys Ser Ser Ser Ser Arg Thr Thr Arg Arg Lys Lys 
             660                 665

 ccagctgcac gtcctgagag ggccaggtcg ccgggagtgc tctggcctcc ggcaggacag   2077

 gacccagcca ctgtgcctta gctgaccctg cagggccagg cacaggttgg ggggctgccc   2137

 ctggggtttg cagggtgctg cattgagggc tccaggcccc acccccacgc cagccatgcc   2197

 cctccccagg actcccacta ttgcctctgt gattggccca ggaggaaaac acgaccaagc   2257

 tcaagaccct tcccctgccc tgggctgtgg gggtctgagt ctagagcccc caaccctagg   2317

 ccccgtgcca gaggggaaga ggctgactcc caggggaaga ggggaagcac tgtcatcttc   2377

 cacgtcatct tcacaccagc ccatcctgcc ctttagatct gggacacaca aaacggagca   2437

 acagtgatcg ggcaacaaca acaacacaac taccaaacgg ccggcgaccc cacgaaactg   2497

 accccggagc gggccccaca caccgccgac aacccacaca ctcccggacc caagaggccc   2557

 caatcggagc agccaaccaa gactcggacg ccaccacgaa caccacgcgt cgagacgcca   2617

 acaccccacg ggacaccgcg cagagacaca ccagatgggc ggaacacgac aaccacccac   2677

 aaaacagcac ggacacaaac acaggtaata gacaaacgac caccgcacag caccatgcaa   2737




      <210> 53
      <211> 3700
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (251)..(2521)

      <400> 53
 attccgcacc aataaagcct tcaaactccc taatctgtgg tttgattcca cccgcgctgc     60

 aagtctctcc cacccaggtg cacatccact gagtagcgtc gctgcgacgg aagggggcgg    120

 ggcctgtggc gcgcagacgc agcttgaact cttgagaggt gggctggggc ttagccaacg    180

 gggcaagggg ggcgggaagg aggtggggtt tctcccagcc aatcgacggg cgcgccctcg    240

 ttgccgctct   atg ccg ctc cgc ccc ggc tcg ctg gtc cca gaa ggc gcc     289
              Met Pro Leu Arg Pro Gly Ser Leu Val Pro Glu Gly Ala
                1               5                  10

 ggg ttt ccc aag atg gcg gcg gac gtg tcc gtt act cac cgg ccc ccg      337
 Gly Phe Pro Lys Met Ala Ala Asp Val Ser Val Thr His Arg Pro Pro
      15                  20                  25

 ctg agc cct aag tct ggg gcc gaa gtc gaa gcc ggc gat gcc gcg gag      385
 Leu Ser Pro Lys Ser Gly Ala Glu Val Glu Ala Gly Asp Ala Ala Glu
  30                  35                  40                  45

 cgc cgg gcg ccg gaa gaa gag ctg ccg cct cta gat cca gaa gag atc      433
 Arg Arg Ala Pro Glu Glu Glu Leu Pro Pro Leu Asp Pro Glu Glu Ile
                  50                  55                  60

 cgg aaa cgc ctg gaa cac acc gag cgc cag ttc cgt aac cgc cgc aag      481
 Arg Lys Arg Leu Glu His Thr Glu Arg Gln Phe Arg Asn Arg Arg Lys
              65                  70                  75

 ata ctg atc cgg ggc ctc ccg ggg gac gtg acc aac cag gaa gta cat      529
 Ile Leu Ile Arg Gly Leu Pro Gly Asp Val Thr Asn Gln Glu Val His
          80                  85                  90

 gac ctg ctc agt gac tat gag ctc aaa tac tgt ttt gtg gac aaa tac      577
 Asp Leu Leu Ser Asp Tyr Glu Leu Lys Tyr Cys Phe Val Asp Lys Tyr
      95                 100                 105

 aaa ggg aca gcc ttc gtg acc ctg ctg aat ggg gag cag gcc gag gcc      625
 Lys Gly Thr Ala Phe Val Thr Leu Leu Asn Gly Glu Gln Ala Glu Ala
 110                 115                 120                 125

 gca atc aat gct ttc cac cag agc cgc ctg cgg gag cgt gaa ctg tcg      673
 Ala Ile Asn Ala Phe His Gln Ser Arg Leu Arg Glu Arg Glu Leu Ser
                 130                 135                 140

 gtg cag ctg cag ccc acg gat gcc ctg ctg tgt gtg gcc aac ctg ccc      721
 Val Gln Leu Gln Pro Thr Asp Ala Leu Leu Cys Val Ala Asn Leu Pro
             145                 150                 155

 ccc agc ctc aca cag cag cag ttc gag gag ctg gtg cgg ccc ttc ggc      769
 Pro Ser Leu Thr Gln Gln Gln Phe Glu Glu Leu Val Arg Pro Phe Gly
         160                 165                 170

 agc ctg gag cgc tgc ttc ctg gtc tac agt gag cgc act ggc caa tcc      817
 Ser Leu Glu Arg Cys Phe Leu Val Tyr Ser Glu Arg Thr Gly Gln Ser
     175                 180                 185

 aag ggc tat ggc ttt gct gag tac atg aag aag gac tcg gct gcc cgt      865
 Lys Gly Tyr Gly Phe Ala Glu Tyr Met Lys Lys Asp Ser Ala Ala Arg
 190                 195                 200                 205

 gcc aag tcg gac ctg ctg ggc aag ccg ctg gga cca cgc acc ctc tac      913
 Ala Lys Ser Asp Leu Leu Gly Lys Pro Leu Gly Pro Arg Thr Leu Tyr
                 210                 215                 220

 gtg cac tgg acg gat gcc ggg caa ctg acg cct gcc ctt ctc cac tcc      961
 Val His Trp Thr Asp Ala Gly Gln Leu Thr Pro Ala Leu Leu His Ser
             225                 230                 235

 cgc tgc ctc tgt gtg gac cgc ctg cca cct ggc ttc aac gat gtg gac     1009
 Arg Cys Leu Cys Val Asp Arg Leu Pro Pro Gly Phe Asn Asp Val Asp
         240                 245                 250

 gct ctg tgc cgg gcg ctg tca gct gtc cac agc ccc acc ttc tgc cag     1057
 Ala Leu Cys Arg Ala Leu Ser Ala Val His Ser Pro Thr Phe Cys Gln
     255                 260                 265

 ctg gcg tgc ggc cag gat ggg cag ctg aag ggc ttc gcg gtg ctg gag     1105
 Leu Ala Cys Gly Gln Asp Gly Gln Leu Lys Gly Phe Ala Val Leu Glu
 270                 275                 280                 285

 tat gag acg gct gag atg gcg gag gag gca cag cag cag gcg gac ggc     1153
 Tyr Glu Thr Ala Glu Met Ala Glu Glu Ala Gln Gln Gln Ala Asp Gly
                 290                 295                 300

 ctg tcc ctg ggg ggc agc cac ctg cga gtc tcc ttc tgc gcc cct ggg     1201
 Leu Ser Leu Gly Gly Ser His Leu Arg Val Ser Phe Cys Ala Pro Gly
             305                 310                 315

 ccc ccc ggc cgc agt atg ctg gcc gct ctc atc gct gcc cag gcc acg     1249
 Pro Pro Gly Arg Ser Met Leu Ala Ala Leu Ile Ala Ala Gln Ala Thr
         320                 325                 330

 gcc ctc aat cgg ggg aag gga ctc ctc ccc gag ccc aac atc ctg cag     1297
 Ala Leu Asn Arg Gly Lys Gly Leu Leu Pro Glu Pro Asn Ile Leu Gln
     335                 340                 345

 ctg ctc aac aac ctg ggc cca tcc gcg tcc ctc cag ctg ctg ctc aac     1345
 Leu Leu Asn Asn Leu Gly Pro Ser Ala Ser Leu Gln Leu Leu Leu Asn
 350                 355                 360                 365

 ccc ctg ctc cat ggc agt gcg ggg ggg aag cag ggc ctc ctg ggt gcc     1393
 Pro Leu Leu His Gly Ser Ala Gly Gly Lys Gln Gly Leu Leu Gly Ala
                 370                 375                 380

 ccc cca gcc atg ccg ctg ctc aat ggg cca gcc ctg tcc acg gcg ctg     1441
 Pro Pro Ala Met Pro Leu Leu Asn Gly Pro Ala Leu Ser Thr Ala Leu
             385                 390                 395

 ttg cag ctc gcc ctg cag acc cag ggc cag aag aag ccc ggc atc ctg     1489
 Leu Gln Leu Ala Leu Gln Thr Gln Gly Gln Lys Lys Pro Gly Ile Leu
         400                 405                 410

 gga gac tca ccc ctg ggc gcc ctc cag cct ggg gcc cag cca gcc aac     1537
 Gly Asp Ser Pro Leu Gly Ala Leu Gln Pro Gly Ala Gln Pro Ala Asn
     415                 420                 425

 ccc ctc ctc ggg gag ctg cct gca gga ggg ggc ctg ccc ccg gag ctg     1585
 Pro Leu Leu Gly Glu Leu Pro Ala Gly Gly Gly Leu Pro Pro Glu Leu
 430                 435                 440                 445

 ccg ccc cgg cga ggg aag cca cca ccc ctg ctg cca tcc gtg ctt ggc     1633
 Pro Pro Arg Arg Gly Lys Pro Pro Pro Leu Leu Pro Ser Val Leu Gly
                 450                 455                 460

 cct gct ggg ggt gac cgg gag gcc ctg ggc ttg ggt ccc cca gcg gcc     1681
 Pro Ala Gly Gly Asp Arg Glu Ala Leu Gly Leu Gly Pro Pro Ala Ala
             465                 470                 475

 cag ctc act cct ccc ccc gcc cct gtg ggg ctc cga ggc tct ggc ctc     1729
 Gln Leu Thr Pro Pro Pro Ala Pro Val Gly Leu Arg Gly Ser Gly Leu
         480                 485                 490

 aga ggc ctc cag aaa gac agt ggg cct ctg ccg acg ccc cct ggg gtc     1777
 Arg Gly Leu Gln Lys Asp Ser Gly Pro Leu Pro Thr Pro Pro Gly Val
     495                 500                 505

 tca ctg ctg ggg gag ccc ccc aag gac tac cgg att ccc ctg aat ccc     1825
 Ser Leu Leu Gly Glu Pro Pro Lys Asp Tyr Arg Ile Pro Leu Asn Pro
 510                 515                 520                 525

 tac ctg aac cta cac agc ctg ctc ccg gcc agc aac ctg gcg ggt aag     1873
 Tyr Leu Asn Leu His Ser Leu Leu Pro Ala Ser Asn Leu Ala Gly Lys
                 530                 535                 540

 gag gcc cgg ggc tgg gga ggc gcc ggg aga agc cgc cgc cca gct gag     1921
 Glu Ala Arg Gly Trp Gly Gly Ala Gly Arg Ser Arg Arg Pro Ala Glu
             545                 550                 555

 ggc ccc cca act aac ccc cca gcc cct gga ggt ggc agc agc agc agc     1969
 Gly Pro Pro Thr Asn Pro Pro Ala Pro Gly Gly Gly Ser Ser Ser Ser
         560                 565                 570

 aaa gcc ttc cag ctc aag tcc cgc ctg ctc agc ccc ctc agc agc gcc     2017
 Lys Ala Phe Gln Leu Lys Ser Arg Leu Leu Ser Pro Leu Ser Ser Ala
     575                 580                 585

 cgc ctg ccc ccc gaa cca gga ctg tct gac agc tac agc ttc gac tac     2065
 Arg Leu Pro Pro Glu Pro Gly Leu Ser Asp Ser Tyr Ser Phe Asp Tyr
 590                 595                 600                 605

 ccc tcg gac atg gga cct cgg cgg ctc ttc tcc cac cca cgg gaa cca     2113
 Pro Ser Asp Met Gly Pro Arg Arg Leu Phe Ser His Pro Arg Glu Pro
                 610                 615                 620

 gcc ctt ggg cct cac gga ccc agc cga cac aag atg tcc ccc ccg ccc     2161
 Ala Leu Gly Pro His Gly Pro Ser Arg His Lys Met Ser Pro Pro Pro
             625                 630                 635

 agt ggc ttc ggc gaa cgg agc agc ggt ggg agt ggc ggg ggc ccc ctg     2209
 Ser Gly Phe Gly Glu Arg Ser Ser Gly Gly Ser Gly Gly Gly Pro Leu
         640                 645                 650

 tct cac ttc tat tca ggc tcg ccc act tcc tac ttc acc agc ggc ctg     2257
 Ser His Phe Tyr Ser Gly Ser Pro Thr Ser Tyr Phe Thr Ser Gly Leu
     655                 660                 665

 cag gct ggc ctc aag cag agc cac ctc agt aag gca atc ggc tct tcc     2305
 Gln Ala Gly Leu Lys Gln Ser His Leu Ser Lys Ala Ile Gly Ser Ser
 670                 675                 680                 685

 ccg ctg ggg tcc gga gaa ggg ctc ctg ggc ctc agc ccc ggg cct aat     2353
 Pro Leu Gly Ser Gly Glu Gly Leu Leu Gly Leu Ser Pro Gly Pro Asn
                 690                 695                 700

 ggt cac agc cac ctg ctg aag acc cca ctg ggc ggc cag aaa cgc agc     2401
 Gly His Ser His Leu Leu Lys Thr Pro Leu Gly Gly Gln Lys Arg Ser
             705                 710                 715

 ttt gcc cac ctg ctg ccc tcg ccc gag ccc agc cca gaa ggc agc tat     2449
 Phe Ala His Leu Leu Pro Ser Pro Glu Pro Ser Pro Glu Gly Ser Tyr
         720                 725                 730

 gtg ggc cag cac tcc cag ggc ctc ggc ggc cac tac gcg gac tcc tac     2497
 Val Gly Gln His Ser Gln Gly Leu Gly Gly His Tyr Ala Asp Ser Tyr
     735                 740                 745

 ctg aag cgg aag agg att ttc taa gtggctggca ccagagataa ctcaagggcc    2551
 Leu Lys Arg Lys Arg Ile Phe 
 750                 755

 tgcaccaaat cgcttttggg ttttctgatg ttttgttttg tgtttttttt aaaccatttt   2611

 ctctctttcg gtaatagaaa aatctctgaa agactttact gaccaatcag ccggagcccc   2671

 aggagcccaa ggggtgtggg ggagtctgga ggcctcatta tgtctctggc ttgctcccca   2731

 cgctgaaacc ctgcagcctt aagagagagg ggccccggcc tgctctccct ccctcccccc   2791

 atctcctcct ccgctgtgcc cgtctctccg gagccctcct gcctcattgc tcctgtaatt   2851

 ttggcctttc gagtgccttg gaggtttccc tgacctcccg tgaagataca gagactgtct   2911

 cctttttttt taactttgac aactgacttc tgtttccttt tctaagtttt atttttcaaa   2971

 ccaccccgga cagcccccag ctctgattcc ttcaaggccc ggcctgtccg ggccaccatt   3031

 ccacaccttg cggtttgaaa cagctgtttt tcccacattt gctgcaggca tggctgtctc   3091

 ctgcccctgc ctgcccatct ggcctatacc ccagccgtgg ggcccggggt ccctgccgca   3151

 gccccctccc cttctgatgc cttaaaagct gggccccagg ccctgctggc cagagccaca   3211

 gatgccaagc tctgggagct tgactatgga ccaaacagct ctggcctagg gattgggcca   3271

 cctaccagga tctccacctg gggacagtaa agggcgaagc tcatcttggc gaaccgggcc   3331

 cacgcaccct acatacccgg ggcatccggg cagagatggg gaaacacaag gcacagtccc   3391

 agggggacag gcgcgagacg atcggacaat gagacaacac ccggagccgg aggcaacaca   3451

 agaagaaaga cacagacact cggcgggcac ccggacagac cgggaaggac acttcccccg   3511

 gcgcggaaac gacccgaaga gagacgggcg gacacgaaca ggacgacagg acgcgcgccc   3571

 cacgaggaga caaacaccga gtggcgccaa cagagaaaca accagcagac acagagcaga   3631

 ggagcgggaa gaaggcgcca ggcaccgagc accaacccca gctgccctga cgagagagac   3691

 ggaagaaag                                                           3700




      <210> 54
      <211> 513
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (241)..(483)

      <400> 54
 cggccgcgtc gacgcgggaa caaactagcc ctcaagacgg gaatagtagc caagaagcag     60

 aagacggagg atgaggtatt aacaagtaaa ggtgacgcgt gggccaagta catggcagaa    120

 gtgaaaaagt acaaagctca ccagtgcggt gacgatgata aaactcggcc cctggtgaaa    180

 tgacgcccct cccccacctg cccatggcct gggactctct gcgatgtaca taactattta    240
                                                                 
 atg cag cgg cag cgg cga cag cct tcc ctg aga gga ctt aaa agc aga      288
 Met Gln Arg Gln Arg Arg Gln Pro Ser Leu Arg Gly Leu Lys Ser Arg
   1               5                  10                  15

 agg aaa ccg aga tgc ttc ccg caa ccg tgg acg att ctc cag gac tct      336
 Arg Lys Pro Arg Cys Phe Pro Gln Pro Trp Thr Ile Leu Gln Asp Ser
              20                  25                  30

 ttt ttt acc ttg agc act tgc ctc gtg aga ctt cat aga aca gtg gtt      384
 Phe Phe Thr Leu Ser Thr Cys Leu Val Arg Leu His Arg Thr Val Val
          35                  40                  45

 tac tgt ccc ccc ctt ctc acc tcc tca ttc tct ctg gct ctt tct gtc      432
 Tyr Cys Pro Pro Leu Leu Thr Ser Ser Phe Ser Leu Ala Leu Ser Val
      50                  55                  60

 ttc ctc ttc tca ccc tcc tcc ctc ccc tta gcc atc act tct ggg aag      480
 Phe Leu Phe Ser Pro Ser Ser Leu Pro Leu Ala Ile Thr Ser Gly Lys
  65                  70                  75                  80

 taa agaacttgac ttagtgccgg aaaaaaaaaa                                 513
 






      <210> 55
      <211> 1015
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (137)..(1015)

      <400> 55
 gactctggct gtagtgtgac attcctgcct gcctgaggaa gaaatggtga gcaggggctg     60

 caattgcaga caagtgtcac ccagaagcca caagtttctg tgagcaccag gtctacaaac    120

 tacccaaggc atagca    atg gca tta tca ctg gaa gaa ttc gtc cac tcc     169
                      Met Ala Leu Ser Leu Glu Glu Phe Val His Ser
                        1               5                  10

 ctt gac ctc agg acc cta ccc agg gtt cta gaa atc cag gca ggc atc      217
 Leu Asp Leu Arg Thr Leu Pro Arg Val Leu Glu Ile Gln Ala Gly Ile
              15                  20                  25

 tat ctt gaa ggc tct att tat gaa atg ttt gga aat gaa tgc tgt ttt      265
 Tyr Leu Glu Gly Ser Ile Tyr Glu Met Phe Gly Asn Glu Cys Cys Phe
          30                  35                  40

 tca aca gga gaa gtg att aaa att act ggt ctc aaa gtt aag aag atc      313
 Ser Thr Gly Glu Val Ile Lys Ile Thr Gly Leu Lys Val Lys Lys Ile
      45                  50                  55

 ata gct gaa att tgt gag cag att gaa ggt tgt gag tct cta cag cca      361
 Ile Ala Glu Ile Cys Glu Gln Ile Glu Gly Cys Glu Ser Leu Gln Pro
  60                  65                  70                  75

 ttt gaa ctg cct atg aat ttt cca ggg act ttt gtt aaa aga agc aag      409
 Phe Glu Leu Pro Met Asn Phe Pro Gly Thr Phe Val Lys Arg Ser Lys
                  80                  85                  90

 gaa tgt ctt ttt aag att gtg gct gat aaa act cca tac ctt act atg      457
 Glu Cys Leu Phe Lys Ile Val Ala Asp Lys Thr Pro Tyr Leu Thr Met
              95                 100                 105

 gaa gaa atc aca agg acc att cat att gga cca agt aga cta ggg cat      505
 Glu Glu Ile Thr Arg Thr Ile His Ile Gly Pro Ser Arg Leu Gly His
         110                 115                 120

 cct tgc ttc tat cat cag aag gat ata aaa cta gag aac ctc atc ata      553
 Pro Cys Phe Tyr His Gln Lys Asp Ile Lys Leu Glu Asn Leu Ile Ile
     125                 130                 135

 aag cag ggt gag caa atc atg ctc aac tca gtt gaa gag att gat gga      601
 Lys Gln Gly Glu Gln Ile Met Leu Asn Ser Val Glu Glu Ile Asp Gly
 140                 145                 150                 155

 gaa ata atg gtg agc tgt gca gta gca agg aat cat caa act cac tca      649
 Glu Ile Met Val Ser Cys Ala Val Ala Arg Asn His Gln Thr His Ser
                 160                 165                 170

 ttt aat ttg cct ttg tca caa gaa gga gaa ttc tac gag tgt gaa gat      697
 Phe Asn Leu Pro Leu Ser Gln Glu Gly Glu Phe Tyr Glu Cys Glu Asp
             175                 180                 185

 gaa cgt att tac act cta aag gag att gtt gaa tgg aag att cct aag      745
 Glu Arg Ile Tyr Thr Leu Lys Glu Ile Val Glu Trp Lys Ile Pro Lys
         190                 195                 200

 aac aga aca aga act gta aac ctt aca gat ttt tca aat aag tgg gac      793
 Asn Arg Thr Arg Thr Val Asn Leu Thr Asp Phe Ser Asn Lys Trp Asp
     205                 210                 215

 tca acg aat cca ttt cct aaa gac ttt tat ggt acc ctg att ctc aag      841
 Ser Thr Asn Pro Phe Pro Lys Asp Phe Tyr Gly Thr Leu Ile Leu Lys
 220                 225                 230                 235

 cct gtt tat gaa att caa ggt gtg atg aaa tgt gag tat cca ctg aga      889
 Pro Val Tyr Glu Ile Gln Gly Val Met Lys Cys Glu Tyr Pro Leu Arg
                 240                 245                 250

 atg atg ttc tat gag cat gag cat tat ggg gtt tgg gaa aga aag att      937
 Met Met Phe Tyr Glu His Glu His Tyr Gly Val Trp Glu Arg Lys Ile
             255                 260                 265

 tta gag cct gaa gaa tgg gag tct gtc ttt att tca act att gag cct      985
 Leu Glu Pro Glu Glu Trp Glu Ser Val Phe Ile Ser Thr Ile Glu Pro
         270                 275                 280

 gtg aga gtt aga ttc ctc atc aat caa taa                             1015
 Val Arg Val Arg Phe Leu Ile Asn Gln 
     285                 290





      <210> 56
      <211> 2777
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1130)..(2260)

      <220>
      <221> misc_feature
      <222> (1)...(2777)
      <223> n = a,t,c or g

      <400> 56
 gatattataa gctgctttat ttttccacga atcntgacgt ctctgcaatg cacatgtgtg     60

 aaaatctgct actgaaacat agagcaagca aacactggca ggtgggtcaa aacgctactg    120

 gtagcaggag gaacgactaa agcaaagtat taccataagg ttaaaacata tggcctgaca    180

 aatgcctgcc agggacacta cacataagga atgtcttcag tgtcccttcg tggggccctg    240

 cagccacccc tgaattccct tggaccccta ggatagaagg ggtcctgtaa atttctttgc    300

 atccacaaaa acgcccccaa tttctgtttg ctttttctcc ttttatcctc caccctagcc    360

 atgttgtcaa attctcttat catgtcctca ttgctgaaat tcatatcatg tatggcttcc    420

 ttatattgct tgaggtactg agccagcccc ttgttggttt ttcttttggc tttcctgggt    480

 atatcatcct cagctgggcg ctttcctgca gcccttgttt cactttctgg ctctccctca    540

 ctctctggct ctctttcact gtctggctct ccttcaccct ctgcccttcc ccctctctct    600

 ggctttccct ctgtctttga tcctccctgc atctctgact ttcccttcct ctctgacttt    660

 ccttctcctt ttgcctttcc cgcactctct ggcttttctt tatcctttaa cggttcctca    720

 actctcttgc ccgtgttttc tgtgtttccc tcgttttcta acttcttgtc ttccagaata    780

 caagctactt ctggctttcc ctcgtgcggt ggctgttctt cattgtctat ctttccttga    840

 ttcgaaggca ttccttcatt ttcattgaag agtttttcca tgtcgagatt tcccctcctt    900

 ttcctttcct gcggggattc tggacaggtt gctcttcctt ttcaggcctc tcagagcgct    960

 gggaacaaca gacgcgcaga cctgcgggga cccaggacag gcctgtgcct cctgcggctc   1020

 gctgaagccc gctcgctgct cccccgccgc tcgtgccgaa ttcggcacga gccgcggagc   1080

 cgggcggagc tggcttgcgg ctcccggggc cggctctccg gccggagac    atg gcc    1135
                                                          Met Ala
                                                            1

 cgg ggg ccc ggc ccg cta ggc agg cct cgc ccc gat acg gtc gcc atg     1183
 Arg Gly Pro Gly Pro Leu Gly Arg Pro Arg Pro Asp Thr Val Ala Met
           5                  10                  15

 ccc aag aga gga aag cga ctc aag ttc cgg gcc cac gac gcc tgc tcc     1231
 Pro Lys Arg Gly Lys Arg Leu Lys Phe Arg Ala His Asp Ala Cys Ser
      20                  25                  30

 ggc cga gtg acc gtg gcg gat tac gcc aac tcg gat ccg gcg gtc gtg     1279
 Gly Arg Val Thr Val Ala Asp Tyr Ala Asn Ser Asp Pro Ala Val Val
  35                  40                  45                  50

 agg tct gga cga gtc aag aaa gcc gta gcc aac gct gtt cag cag gaa     1327
 Arg Ser Gly Arg Val Lys Lys Ala Val Ala Asn Ala Val Gln Gln Glu
                  55                  60                  65

 gta aaa tct ctt tgt ggc ttg gaa gcc tct cag gtt cct gca gag gaa     1375
 Val Lys Ser Leu Cys Gly Leu Glu Ala Ser Gln Val Pro Ala Glu Glu
              70                  75                  80

 gct ctt tct ggg gct ggt gag ccc tgt gac atc atc gac agc agt gat     1423
 Ala Leu Ser Gly Ala Gly Glu Pro Cys Asp Ile Ile Asp Ser Ser Asp
          85                  90                  95

 gag atg gat gcc cag gag gaa agc atc cat gag aga act gtc tcc aga     1471
 Glu Met Asp Ala Gln Glu Glu Ser Ile His Glu Arg Thr Val Ser Arg
     100                 105                 110

 aaa aag aaa agc aag aga cac aaa gaa gaa ctg gac ggg gct gga gga     1519
 Lys Lys Lys Ser Lys Arg His Lys Glu Glu Leu Asp Gly Ala Gly Gly
 115                 120                 125                 130

 gaa gag tat ccc atg gat att tgg cta ttg ctg gcc tcc tat atc cgt     1567
 Glu Glu Tyr Pro Met Asp Ile Trp Leu Leu Leu Ala Ser Tyr Ile Arg
                 135                 140                 145

 cct gag gac att gtg aat ttt tcc ctg att tgt aag aat gcc tgg act     1615
 Pro Glu Asp Ile Val Asn Phe Ser Leu Ile Cys Lys Asn Ala Trp Thr
             150                 155                 160

 gtc act tgc act gct gcc ttt tgg acc agg ttg tac cga agg cac tac     1663
 Val Thr Cys Thr Ala Ala Phe Trp Thr Arg Leu Tyr Arg Arg His Tyr
         165                 170                 175

 acg ctg gat gct tcc ctg cct ttg cgt ctg cga cca gag tca atg gag     1711
 Thr Leu Asp Ala Ser Leu Pro Leu Arg Leu Arg Pro Glu Ser Met Glu
     180                 185                 190

 aag ctg cgc tgt ctc cgg gct tgt gtg atc cga tct ctg tac cat atg     1759
 Lys Leu Arg Cys Leu Arg Ala Cys Val Ile Arg Ser Leu Tyr His Met
 195                 200                 205                 210

 tat gag cca ttt gct gct cga atc tcc aag aat cca gcc att cca gaa     1807
 Tyr Glu Pro Phe Ala Ala Arg Ile Ser Lys Asn Pro Ala Ile Pro Glu
                 215                 220                 225

 agc acc ccc agc aca tta aag aat tcc aaa tgc tta ctt ttc tgg tgc     1855
 Ser Thr Pro Ser Thr Leu Lys Asn Ser Lys Cys Leu Leu Phe Trp Cys
             230                 235                 240

 aga aag att gtt ggg aac aga cag gaa cca atg tgg gaa ttc aac ttc     1903
 Arg Lys Ile Val Gly Asn Arg Gln Glu Pro Met Trp Glu Phe Asn Phe
         245                 250                 255

 aag ttc aaa aaa cag tcc cct agg tta aag agc aag tgt aca gga gga     1951
 Lys Phe Lys Lys Gln Ser Pro Arg Leu Lys Ser Lys Cys Thr Gly Gly
     260                 265                 270

 ttg cag cct ccc gtt cag tac gaa gat gtt cat acc aat cca gac cag     1999
 Leu Gln Pro Pro Val Gln Tyr Glu Asp Val His Thr Asn Pro Asp Gln
 275                 280                 285                 290

 gac tgc tgc cta ctg cag gtc acc acc ctc aat ttc atc ttt att ccg     2047
 Asp Cys Cys Leu Leu Gln Val Thr Thr Leu Asn Phe Ile Phe Ile Pro
                 295                 300                 305

 att gtc atg gga atg ata ttt act ctg ttt act atc aat gtg agc acg     2095
 Ile Val Met Gly Met Ile Phe Thr Leu Phe Thr Ile Asn Val Ser Thr
             310                 315                 320

 gac atg cgg cat cat cga gtg aga ctg gtg ttc caa gat tcc cct gtc     2143
 Asp Met Arg His His Arg Val Arg Leu Val Phe Gln Asp Ser Pro Val
         325                 330                 335

 cat ggt ggt cgg aaa ctg cgc agt gaa cag ggt gtg caa gtc atc ctg     2191
 His Gly Gly Arg Lys Leu Arg Ser Glu Gln Gly Val Gln Val Ile Leu
     340                 345                 350

 gac cca gtg cac agc gtt cgg ctc ttt gac tgg tgg cat cct cag tac     2239
 Asp Pro Val His Ser Val Arg Leu Phe Asp Trp Trp His Pro Gln Tyr
 355                 360                 365                 370

 cca ttc tcc ctg aga gcg tag tt actgcttccc atcccttggg ggcagcctcg     2292
 Pro Phe Ser Leu Arg Ala 
                 375

 agtgtagtcc attagtaatc agattccagt ttggacaggg tggctggatt gtatatctcg   2352

 ttagtaatgt acatgctctt caggttctag ggctcctgtt aggggaggga gaaatgttga   2412

 atcaagaggg aaaacaacta ctatgattta taaacatatt ttaatgtaaa aatttgcatt   2472

 taaaaggagt ggccctgttt tctgtgttaa aaccccattt ggtgctattg agtttgttct   2532

 ttattctttt atcccagtga aaattgttga tcttgctgta gggaaaaatt aaactctttg   2592

 aatctccaaa caaggaagtt tcagcattcc cttatggatc agaggaacct tagaggcctg   2652

 aaattgttgc ttccagttta gctgcccctc aaattcaagt gaatattttc ccttctccct   2712

 ttacccttct ccagaaataa agcaggtgac agggttttca gaatcttaaa aaaaaaaaaa   2772

 aaaaa                                                               2777




      <210> 57
      <211> 3608
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(3449)

      <400> 57
 aattcttcat tcattttttc accatttatt cactcattca cttaccatct gttaaatcct     60

 ggacc    atg gtt ctg ctt ggt agt gag gat aca ata ctg agt aac aaa     107
          Met Val Leu Leu Gly Ser Glu Asp Thr Ile Leu Ser Asn Lys
            1               5                  10

 cag tcc cta cta gtt cct gtc cct gag gac ctg ccg tat gcc tgc aca      155
 Gln Ser Leu Leu Val Pro Val Pro Glu Asp Leu Pro Tyr Ala Cys Thr
  15                  20                  25                  30

 ttg cct gac cct atg ttt gcc att ggg aca caa aga gag tct tgc tgc      203
 Leu Pro Asp Pro Met Phe Ala Ile Gly Thr Gln Arg Glu Ser Cys Cys
                  35                  40                  45

 ccc gga tgt gat gac gtg cta ctg gaa gct tcc atc cag cag aca ggg      251
 Pro Gly Cys Asp Asp Val Leu Leu Glu Ala Ser Ile Gln Gln Thr Gly
              50                  55                  60

 aac cac agg gca cga aca aaa gag gtc atg tgg tgg cag gca cgc tac      299
 Asn His Arg Ala Arg Thr Lys Glu Val Met Trp Trp Gln Ala Arg Tyr
          65                  70                  75

 gct ttc aga aat gag ctc ttg aat tcg acc ttg cat gaa gtt ctt ctg      347
 Ala Phe Arg Asn Glu Leu Leu Asn Ser Thr Leu His Glu Val Leu Leu
      80                  85                  90

 gga atg ctg gga atg aac atc aca gca aca gta aga aga ttt ggc tgt      395
 Gly Met Leu Gly Met Asn Ile Thr Ala Thr Val Arg Arg Phe Gly Cys
  95                 100                 105                 110

 gta aag tgg agg gtg att tat gcc ctg aac acc cgc cag gat gag gct      443
 Val Lys Trp Arg Val Ile Tyr Ala Leu Asn Thr Arg Gln Asp Glu Ala
                 115                 120                 125

 gag gcc agc atg gag gcg ctg cgg gaa gcg cac cag gag gag ctc cag      491
 Glu Ala Ser Met Glu Ala Leu Arg Glu Ala His Gln Glu Glu Leu Gln
             130                 135                 140

 aat gcg gtg gca gag acc aag gcc agg ctc ctg cag gaa cag ggc tgc      539
 Asn Ala Val Ala Glu Thr Lys Ala Arg Leu Leu Gln Glu Gln Gly Cys
         145                 150                 155

 gca gag gag gaa gcc ctt cta cag cgc atc cag gcc ctg gag agc gcc      587
 Ala Glu Glu Glu Ala Leu Leu Gln Arg Ile Gln Ala Leu Glu Ser Ala
     160                 165                 170

 ctg gag ctg caa aag agg ctg acg gag gag gcg ctg gct gag tcg gcc      635
 Leu Glu Leu Gln Lys Arg Leu Thr Glu Glu Ala Leu Ala Glu Ser Ala
 175                 180                 185                 190

 tcg tgc agg ctg gag acg aag gag aga gag ctg agg gtg gag gca gag      683
 Ser Cys Arg Leu Glu Thr Lys Glu Arg Glu Leu Arg Val Glu Ala Glu
                 195                 200                 205

 cac gcc gag cga gtc ctc acg ctc tcc agg gaa atg ctg gag ctc aag      731
 His Ala Glu Arg Val Leu Thr Leu Ser Arg Glu Met Leu Glu Leu Lys
             210                 215                 220

 gct gac tac gag agg agg ctc cag cac ctg acg agc cac gag gct acc      779
 Ala Asp Tyr Glu Arg Arg Leu Gln His Leu Thr Ser His Glu Ala Thr
         225                 230                 235

 ccg cag ggc cgg ctg ccc cag gag agc cct gaa acc aag tcg gag cca      827
 Pro Gln Gly Arg Leu Pro Gln Glu Ser Pro Glu Thr Lys Ser Glu Pro
     240                 245                 250

 ggc cag ggc ccg gag atg cag gag gtc ctg cta gag gtg cag cgg ctg      875
 Gly Gln Gly Pro Glu Met Gln Glu Val Leu Leu Glu Val Gln Arg Leu
 255                 260                 265                 270

 cga gtg gag aac cag cag ctg agc aag gac tac gcc cgc aag gcc gag      923
 Arg Val Glu Asn Gln Gln Leu Ser Lys Asp Tyr Ala Arg Lys Ala Glu
                 275                 280                 285

 gag ctg cag gcc acc tac gag agg gaa aac gag gcc atc cgg cag gcc      971
 Glu Leu Gln Ala Thr Tyr Glu Arg Glu Asn Glu Ala Ile Arg Gln Ala
             290                 295                 300

 atg cag cag tcg gtg agc cag gcc ctg tgg cag tgg cag gag aag gag     1019
 Met Gln Gln Ser Val Ser Gln Ala Leu Trp Gln Trp Gln Glu Lys Glu
         305                 310                 315

 tcg gac ctc cgc aag aac ttc cag gtc cag gag tca gcc ctg cag gct     1067
 Ser Asp Leu Arg Lys Asn Phe Gln Val Gln Glu Ser Ala Leu Gln Ala
     320                 325                 330

 cag gtc cgg aag ctg gaa gga gac ctg gag cac aga ggc cgc aag ata     1115
 Gln Val Arg Lys Leu Glu Gly Asp Leu Glu His Arg Gly Arg Lys Ile
 335                 340                 345                 350

 agt gac ctg aag aag tac gcc cag aag ctg aag gag agg att cag gac     1163
 Ser Asp Leu Lys Lys Tyr Ala Gln Lys Leu Lys Glu Arg Ile Gln Asp
                 355                 360                 365

 ctg gat gtg cag ctt aag gag gct cga cag gag aat tca gag ttg aaa     1211
 Leu Asp Val Gln Leu Lys Glu Ala Arg Gln Glu Asn Ser Glu Leu Lys
             370                 375                 380

 ggc act gca aaa aaa ctt ggg gag aag ctg gct gtt gcc aaa gac aga     1259
 Gly Thr Ala Lys Lys Leu Gly Glu Lys Leu Ala Val Ala Lys Asp Arg
         385                 390                 395

 atg atg ctg cag gag tgt cgt ggg aca cag cag aca gat gcc atg aag     1307
 Met Met Leu Gln Glu Cys Arg Gly Thr Gln Gln Thr Asp Ala Met Lys
     400                 405                 410

 act gag tta gtt tca gag aac aaa gtc ctg cgg gaa gag aat gac ttg     1355
 Thr Glu Leu Val Ser Glu Asn Lys Val Leu Arg Glu Glu Asn Asp Leu
 415                 420                 425                 430

 gaa gcc ggc aat ctt cat cct cag cag gat caa agc tgt ctc aag gag     1403
 Glu Ala Gly Asn Leu His Pro Gln Gln Asp Gln Ser Cys Leu Lys Glu
                 435                 440                 445

 tgc cct tgc atg aaa gga ggc aca gat atg cag acc aag aaa gag gca     1451
 Cys Pro Cys Met Lys Gly Gly Thr Asp Met Gln Thr Lys Lys Glu Ala
             450                 455                 460

 agt gct gag aca gaa tat atg aag caa caa tat gaa gaa gac ctt cgt     1499
 Ser Ala Glu Thr Glu Tyr Met Lys Gln Gln Tyr Glu Glu Asp Leu Arg
         465                 470                 475

 aaa atc aaa cat cag aca gaa gag gag aag aaa cat ctc aaa gac cag     1547
 Lys Ile Lys His Gln Thr Glu Glu Glu Lys Lys His Leu Lys Asp Gln
     480                 485                 490

 cta gtg aag cga cta gaa gac ttg gta aag aag cac acc gtg gaa atc     1595
 Leu Val Lys Arg Leu Glu Asp Leu Val Lys Lys His Thr Val Glu Ile
 495                 500                 505                 510

 aaa tcc gtt cgc tcg tcc gtg gag gct gaa aga aag aaa ctg cag agg     1643
 Lys Ser Val Arg Ser Ser Val Glu Ala Glu Arg Lys Lys Leu Gln Arg
                 515                 520                 525

 gaa gta gaa gca cag ttg gag gaa gtg agg aag aaa tca gaa aag gag     1691
 Glu Val Glu Ala Gln Leu Glu Glu Val Arg Lys Lys Ser Glu Lys Glu
             530                 535                 540

 ata aag cag ctg gaa gaa gag aaa gca gcc ctc aat gtg aag ctt cag     1739
 Ile Lys Gln Leu Glu Glu Glu Lys Ala Ala Leu Asn Val Lys Leu Gln
         545                 550                 555

 aat tct ctg ctt gag gtt tta agg ctg gaa gaa ttt atc caa caa aat     1787
 Asn Ser Leu Leu Glu Val Leu Arg Leu Glu Glu Phe Ile Gln Gln Asn
     560                 565                 570

 aag aca cgc ccc aca gga gct gag gaa agt ccc cag gaa tta ggc cgc     1835
 Lys Thr Arg Pro Thr Gly Ala Glu Glu Ser Pro Gln Glu Leu Gly Arg
 575                 580                 585                 590

 cag cac tgc agc att ctg gag acc cag gat cca tgc ttg aag ctg gat     1883
 Gln His Cys Ser Ile Leu Glu Thr Gln Asp Pro Cys Leu Lys Leu Asp
                 595                 600                 605

 gaa act tcg ccg aga gga gag gag tat caa gat aag tta gca gct gaa     1931
 Glu Thr Ser Pro Arg Gly Glu Glu Tyr Gln Asp Lys Leu Ala Ala Glu
             610                 615                 620

 gaa gga acc agc agt gat gaa gaa gaa agg acc aaa gtg ctt ctc aag     1979
 Glu Gly Thr Ser Ser Asp Glu Glu Glu Arg Thr Lys Val Leu Leu Lys
         625                 630                 635

 gag gga agt gac cca caa cct cca ctg ggc tct ttg ttg aag gag aaa     2027
 Glu Gly Ser Asp Pro Gln Pro Pro Leu Gly Ser Leu Leu Lys Glu Lys
     640                 645                 650

 aca tcc aaa atc cag cgt cta gag gag gac tgg caa agc cag aag gcc     2075
 Thr Ser Lys Ile Gln Arg Leu Glu Glu Asp Trp Gln Ser Gln Lys Ala
 655                 660                 665                 670

 aaa ttg caa gcc cag gtc tca cag atg cag cag gct ctg gag cag tgc     2123
 Lys Leu Gln Ala Gln Val Ser Gln Met Gln Gln Ala Leu Glu Gln Cys
                 675                 680                 685

 acc agc aac tac agg gag gac ctg cag gca ctc aag cag ctc tcg gac     2171
 Thr Ser Asn Tyr Arg Glu Asp Leu Gln Ala Leu Lys Gln Leu Ser Asp
             690                 695                 700

 ctg gag agg gag aag ctg cag cgt gag ctc cag gag acc act cag cag     2219
 Leu Glu Arg Glu Lys Leu Gln Arg Glu Leu Gln Glu Thr Thr Gln Gln
         705                 710                 715

 aac cac gcc atg aaa gcc cag ctc gag gct tcc cac cag aga gcc ctg     2267
 Asn His Ala Met Lys Ala Gln Leu Glu Ala Ser His Gln Arg Ala Leu
     720                 725                 730

 cgc atg ctg gag aag gcc aga cat cag gaa ctc aag gcc aca gag gaa     2315
 Arg Met Leu Glu Lys Ala Arg His Gln Glu Leu Lys Ala Thr Glu Glu
 735                 740                 745                 750

 cgc ttg aag aag gaa tcc agc cac agc ctc cag atc caa cac cag aca     2363
 Arg Leu Lys Lys Glu Ser Ser His Ser Leu Gln Ile Gln His Gln Thr
                 755                 760                 765

 cac cga ctg gag ctc cag gcc ttg gag gaa aag gcc agg caa gag ctg     2411
 His Arg Leu Glu Leu Gln Ala Leu Glu Glu Lys Ala Arg Gln Glu Leu
             770                 775                 780

 cag gag gag cgt gag agg atg cag gca cag cag gcc ctg ctg cta gag     2459
 Gln Glu Glu Arg Glu Arg Met Gln Ala Gln Gln Ala Leu Leu Leu Glu
         785                 790                 795

 tcg ctc aga cag gag ctg tcg gag cag caa gct gcc tgt tct ggg cac     2507
 Ser Leu Arg Gln Glu Leu Ser Glu Gln Gln Ala Ala Cys Ser Gly His
     800                 805                 810

 cag aag gac ttg gag gca ctg cag gcc gag ctg agg gct ctg ggc aga     2555
 Gln Lys Asp Leu Glu Ala Leu Gln Ala Glu Leu Arg Ala Leu Gly Arg
 815                 820                 825                 830

 cag caa gcc agc agc cag tgt cca gga gac agc aag gat cac ata atc     2603
 Gln Gln Ala Ser Ser Gln Cys Pro Gly Asp Ser Lys Asp His Ile Ile
                 835                 840                 845

 gcc aca gag gag tgg ggc ggc ccg ggc cag gcc ggc tcc cca ccg ggc     2651
 Ala Thr Glu Glu Trp Gly Gly Pro Gly Gln Ala Gly Ser Pro Pro Gly
             850                 855                 860

 gct gct ggg cag ggt tcc ggc gag gga tgc ggg ctc tgg gag gag aac     2699
 Ala Ala Gly Gln Gly Ser Gly Glu Gly Cys Gly Leu Trp Glu Glu Asn
         865                 870                 875

 gcg cag ctc cag gac gcg gtg cgg cgg ctg cgc gcg gag gtg gag cag     2747
 Ala Gln Leu Gln Asp Ala Val Arg Arg Leu Arg Ala Glu Val Glu Gln
     880                 885                 890

 cat cag cag gag gcg cag aag ctc cga gac cag cgc agg ttc ctg gag     2795
 His Gln Gln Glu Ala Gln Lys Leu Arg Asp Gln Arg Arg Phe Leu Glu
 895                 900                 905                 910

 gag act cag caa gcc cag cgg gcc agg gag gtg gag aca ctg cgc cag     2843
 Glu Thr Gln Gln Ala Gln Arg Ala Arg Glu Val Glu Thr Leu Arg Gln
                 915                 920                 925

 gaa cac cgg aag gag atg cag gcc atg gtg gca gat ttc agt agt gcc     2891
 Glu His Arg Lys Glu Met Gln Ala Met Val Ala Asp Phe Ser Ser Ala
             930                 935                 940

 cag gcc cag ctc cag gcc cgg ctg gct gcc ctg gaa gcc gaa ctg aaa     2939
 Gln Ala Gln Leu Gln Ala Arg Leu Ala Ala Leu Glu Ala Glu Leu Lys
         945                 950                 955

 gat tcc gga gag aag cca ggg aag gga gcg tcc agg ccc gag gac ctt     2987
 Asp Ser Gly Glu Lys Pro Gly Lys Gly Ala Ser Arg Pro Glu Asp Leu
     960                 965                 970

 cag ctc att ggc cgc ctg cag acc cgc ctg aag gag aga gag gac atc     3035
 Gln Leu Ile Gly Arg Leu Gln Thr Arg Leu Lys Glu Arg Glu Asp Ile
 975                 980                 985                 990

 atc aag cag ctc acg gaa gag aga aga ttt cac tac gca gca ttc ccc     3083
 Ile Lys Gln Leu Thr Glu Glu Arg Arg Phe His Tyr Ala Ala Phe Pro
                 995                1000                1005

 agt gcc atg tcc cac cgg aat cgg tct ttc tct ttc aat cct cac ccg     3131
 Ser Ala Met Ser His Arg Asn Arg Ser Phe Ser Phe Asn Pro His Pro
            1010                1015                1020

 gga tat ttg acc cct tcc atg aag aaa aag aag gtg gag gac gtg ccc     3179
 Gly Tyr Leu Thr Pro Ser Met Lys Lys Lys Lys Val Glu Asp Val Pro
        1025                1030                1035

 agc cgc gtg gtc agc gtg ccg aac ctc gcc tcc tat gca aag aac ttt     3227
 Ser Arg Val Val Ser Val Pro Asn Leu Ala Ser Tyr Ala Lys Asn Phe
    1040                1045                1050

 ctg agt ggc gat ctg agt tcc agg att aat gcc cct cca ata act aca     3275
 Leu Ser Gly Asp Leu Ser Ser Arg Ile Asn Ala Pro Pro Ile Thr Thr
1055                1060                1065                1070

 tca ccc agc ttg gac cca agc ccc agc tgt ggc cgg acc tac aaa ccc     3323
 Ser Pro Ser Leu Asp Pro Ser Pro Ser Cys Gly Arg Thr Tyr Lys Pro
                1075                1080                1085

 aac cag tct aca gat gca aaa act gcc aca agg acc cca gat ggt gaa     3371
 Asn Gln Ser Thr Asp Ala Lys Thr Ala Thr Arg Thr Pro Asp Gly Glu
            1090                1095                1100

 acg gcc caa gcc aaa gaa gcc cag cag aaa cag ggc tct ccg cac cag     3419
 Thr Ala Gln Ala Lys Glu Ala Gln Gln Lys Gln Gly Ser Pro His Gln
        1105                1110                1115

 gaa tgg ttc acc aag tac ttt tct ttc taa g ctaacctttg ggatacatca     3470
 Glu Trp Phe Thr Lys Tyr Phe Ser Phe 
    1120                1125

 cagaggatac ttgaaaaaca tttattttaa atcatccgat tgaaggaatg aactaacacc   3530

 aaccaaccaa ataatatgct tatgatttat atatgatagc taaaacaaat tttggcgtta   3590

 acacttcata ctgttctc                                                 3608




      <210> 58
      <211> 5909
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (482)..(4093)

      <400> 58
 ggcagagcta acctctcaga ggacccgaag gagagggaga cggagacagg ggctaaaagg     60

 gaagggatag agggacagca cgcgagacgg aaaggagcgc ctcagagtct ctgaagcacg    120

 caagagataa ccgattagga atttttcggg caactgtcac ccggatagct gtcagagaat    180

 catcatcacc gcaactctga cgtttcctac aagaagttag agacttaagc agtattggca    240

 tcggatggaa atgggatgca tgctgctgtg gaaaatatcc ctgagctgaa gaagtgcaac    300

 tatgtgttgt gtgtgctaaa tgcccagaag aacccagacc cagtggcggc tgtctccaaa    360

 taagtgatga gatataatgc atcctccagt ccatgcacgc ttcctcttgc aatttgggca    420

 tcattcctca gtggaaacct ttaaaccctg aaatccagga aaagaaaata aatacattat    480

 c    atg gac ctg agg gat ttt tac ctg ttg gct gct ctg att gcc tgt     526
      Met Asp Leu Arg Asp Phe Tyr Leu Leu Ala Ala Leu Ile Ala Cys
        1               5                  10                  15

 tta agg ctg gat tcc gca ata gct caa gaa ctt att tac act att aga      574
 Leu Arg Leu Asp Ser Ala Ile Ala Gln Glu Leu Ile Tyr Thr Ile Arg
                  20                  25                  30

 gag gaa ttg cct gaa aat gtg ccc ata gga aac ata cca aag gat ctg      622
 Glu Glu Leu Pro Glu Asn Val Pro Ile Gly Asn Ile Pro Lys Asp Leu
              35                  40                  45

 aac att tct cac atc aat gct gcc aca ggg acc agc gcc agc ctt gtc      670
 Asn Ile Ser His Ile Asn Ala Ala Thr Gly Thr Ser Ala Ser Leu Val
          50                  55                  60

 tac aga ctg gtt tct aaa gct ggg gat gcc cct ttg gtg aaa gta tcc      718
 Tyr Arg Leu Val Ser Lys Ala Gly Asp Ala Pro Leu Val Lys Val Ser
      65                  70                  75

 agc agc act ggg gaa att ttc aca acc tcc aac aga ata gac aga gaa      766
 Ser Ser Thr Gly Glu Ile Phe Thr Thr Ser Asn Arg Ile Asp Arg Glu
  80                  85                  90                  95

 aaa ctc tgt gct ggc gcc tca tat gct gag gag aat gag tgt ttc ttt      814
 Lys Leu Cys Ala Gly Ala Ser Tyr Ala Glu Glu Asn Glu Cys Phe Phe
                 100                 105                 110

 gaa ctt gag gtg gtg atc ctc ccc aat gat ttc ttc agg ctg atc aaa      862
 Glu Leu Glu Val Val Ile Leu Pro Asn Asp Phe Phe Arg Leu Ile Lys
             115                 120                 125

 ata aaa ata att gtc aag gat acc aat gat aat gcc ccc atg ttt cca      910
 Ile Lys Ile Ile Val Lys Asp Thr Asn Asp Asn Ala Pro Met Phe Pro
         130                 135                 140

 tct cct gtc atc aat att tcc att cca gaa aac act ttg atc aac agc      958
 Ser Pro Val Ile Asn Ile Ser Ile Pro Glu Asn Thr Leu Ile Asn Ser
     145                 150                 155

 cgc ttt cca att cca tca gca aca gat cct gac aca ggc ttc aat ggt     1006
 Arg Phe Pro Ile Pro Ser Ala Thr Asp Pro Asp Thr Gly Phe Asn Gly
 160                 165                 170                 175

 gta cag cat tat gaa ttg tta aat ggg cag agt gtt ttt gga ctg gat     1054
 Val Gln His Tyr Glu Leu Leu Asn Gly Gln Ser Val Phe Gly Leu Asp
                 180                 185                 190

 atc gtg gaa act cca gag gga gag aag tgg cca caa ctg att gtt cag     1102
 Ile Val Glu Thr Pro Glu Gly Glu Lys Trp Pro Gln Leu Ile Val Gln
             195                 200                 205

 caa aac ttg gat aga gaa cag aaa gat acc tat gtg atg aaa atc aaa     1150
 Gln Asn Leu Asp Arg Glu Gln Lys Asp Thr Tyr Val Met Lys Ile Lys
         210                 215                 220

 gta gag gat gga ggc act cca cag aaa tcc agt acg gcc ata ctg cag     1198
 Val Glu Asp Gly Gly Thr Pro Gln Lys Ser Ser Thr Ala Ile Leu Gln
     225                 230                 235

 gtc aca gta agt gat gta aat gac aac agg cca gtg ttt aaa gag ggt     1246
 Val Thr Val Ser Asp Val Asn Asp Asn Arg Pro Val Phe Lys Glu Gly
 240                 245                 250                 255

 caa gtg gag gtg cat att cca gag aat gct ccc gta ggt acc tct gta     1294
 Gln Val Glu Val His Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val
                 260                 265                 270

 att cag ctc cat gcc act gat gca gat ata ggc agt aat gct gaa atc     1342
 Ile Gln Leu His Ala Thr Asp Ala Asp Ile Gly Ser Asn Ala Glu Ile
             275                 280                 285

 cgg tac att ttt ggt gcc cag gtc gcc cct gca acc aaa aga ctc ttt     1390
 Arg Tyr Ile Phe Gly Ala Gln Val Ala Pro Ala Thr Lys Arg Leu Phe
         290                 295                 300

 gct tta aat aat act act ggg ctg att aca gtt cag agg tcc tta gat     1438
 Ala Leu Asn Asn Thr Thr Gly Leu Ile Thr Val Gln Arg Ser Leu Asp
     305                 310                 315

 aga gag gag aca gcc att cac aaa gtg aca gtg ctg gct agt gac ggc     1486
 Arg Glu Glu Thr Ala Ile His Lys Val Thr Val Leu Ala Ser Asp Gly
 320                 325                 330                 335

 agc tcc act cct gct cga gca acg gtt acc atc aat gtc acc gat gta     1534
 Ser Ser Thr Pro Ala Arg Ala Thr Val Thr Ile Asn Val Thr Asp Val
                 340                 345                 350

 aat gat aac cct cct aat ata gac ctc agg tac att ata agt ccc atc     1582
 Asn Asp Asn Pro Pro Asn Ile Asp Leu Arg Tyr Ile Ile Ser Pro Ile
             355                 360                 365

 aat ggc acc gtg tat tta tct gag aaa gat cct gtc aat aca aag att     1630
 Asn Gly Thr Val Tyr Leu Ser Glu Lys Asp Pro Val Asn Thr Lys Ile
         370                 375                 380

 gcc cta att aca gtt tca gat aag gac aca gat gtg aat ggc aaa gtg     1678
 Ala Leu Ile Thr Val Ser Asp Lys Asp Thr Asp Val Asn Gly Lys Val
     385                 390                 395

 atc tgt ttt att gaa aga gag gtc cca ttt cat ttg aag gcg gta tat     1726
 Ile Cys Phe Ile Glu Arg Glu Val Pro Phe His Leu Lys Ala Val Tyr
 400                 405                 410                 415

 gac aac caa tat ttg tta gag acc tct tct ttg ttg gac tat gag ggc     1774
 Asp Asn Gln Tyr Leu Leu Glu Thr Ser Ser Leu Leu Asp Tyr Glu Gly
                 420                 425                 430

 acc aaa gaa ttc agc ttt aaa att gtt gcc tct gat tct ggg aag ccc     1822
 Thr Lys Glu Phe Ser Phe Lys Ile Val Ala Ser Asp Ser Gly Lys Pro
             435                 440                 445

 agt tta aat cag act gcc ctg gta agg gtt aag ctt gag gat gaa aat     1870
 Ser Leu Asn Gln Thr Ala Leu Val Arg Val Lys Leu Glu Asp Glu Asn
         450                 455                 460

 gac aac cca cca att ttc aac cag cct gta att gag ctg tca gtt tct     1918
 Asp Asn Pro Pro Ile Phe Asn Gln Pro Val Ile Glu Leu Ser Val Ser
     465                 470                 475

 gaa aac aac cga cgt ggg tta tac tta aca act att agt gcc aca gat     1966
 Glu Asn Asn Arg Arg Gly Leu Tyr Leu Thr Thr Ile Ser Ala Thr Asp
 480                 485                 490                 495

 gaa gac agt ggg aaa aat gca gac att gtt tat cag ctt gga ccg aat     2014
 Glu Asp Ser Gly Lys Asn Ala Asp Ile Val Tyr Gln Leu Gly Pro Asn
                 500                 505                 510

 gcc tcc ttc ttt gat ctg gac cga aaa aca gga gtt ttg aca gcc tcc     2062
 Ala Ser Phe Phe Asp Leu Asp Arg Lys Thr Gly Val Leu Thr Ala Ser
             515                 520                 525

 aga gta ttt gac aga gaa gaa caa gaa cga ttc att ttt aca gta act     2110
 Arg Val Phe Asp Arg Glu Glu Gln Glu Arg Phe Ile Phe Thr Val Thr
         530                 535                 540

 gcc agg gat aat ggg acc cct ccc ctc caa agc caa gcg gct gtg att     2158
 Ala Arg Asp Asn Gly Thr Pro Pro Leu Gln Ser Gln Ala Ala Val Ile
     545                 550                 555

 gtt act gtt ctg gat gag aat gac aat agc ccc aag ttt act cat aat     2206
 Val Thr Val Leu Asp Glu Asn Asp Asn Ser Pro Lys Phe Thr His Asn
 560                 565                 570                 575

 cat ttt caa ttt ttt gtg tct gag aat ctg cca aag tat agt act gtg     2254
 His Phe Gln Phe Phe Val Ser Glu Asn Leu Pro Lys Tyr Ser Thr Val
                 580                 585                 590

 ggg gta atc aca gtg aca gat gca gat gct gga gag aat aaa gct gtg     2302
 Gly Val Ile Thr Val Thr Asp Ala Asp Ala Gly Glu Asn Lys Ala Val
             595                 600                 605

 act ctt tcc att cta aat gac aat gat aat ttt gtg ttg gat ccc tat     2350
 Thr Leu Ser Ile Leu Asn Asp Asn Asp Asn Phe Val Leu Asp Pro Tyr
         610                 615                 620

 tct gga gtc ata aag tca aat gtc tca ttt gat aga gag cag cag agt     2398
 Ser Gly Val Ile Lys Ser Asn Val Ser Phe Asp Arg Glu Gln Gln Ser
     625                 630                 635

 tcc tac act ttt gat gtc aaa gcc act gat gga gga caa cca cct cgt     2446
 Ser Tyr Thr Phe Asp Val Lys Ala Thr Asp Gly Gly Gln Pro Pro Arg
 640                 645                 650                 655

 tcc tct act gca aaa gta act atc aac gtc atg gat gtc aat gac aac     2494
 Ser Ser Thr Ala Lys Val Thr Ile Asn Val Met Asp Val Asn Asp Asn
                 660                 665                 670

 agc cca gtt gtc att tct cca ccg tct aat act tcc ttt aag ttg gtg     2542
 Ser Pro Val Val Ile Ser Pro Pro Ser Asn Thr Ser Phe Lys Leu Val
             675                 680                 685

 ccc ctc tca gcc att cct ggc tcc gtg gta gca gaa gtt ttt gca gtg     2590
 Pro Leu Ser Ala Ile Pro Gly Ser Val Val Ala Glu Val Phe Ala Val
         690                 695                 700

 gat gtt gac act gga atg aac gct gaa cta aag tat act ata gtg agt     2638
 Asp Val Asp Thr Gly Met Asn Ala Glu Leu Lys Tyr Thr Ile Val Ser
     705                 710                 715

 gga aac aat aaa ggc tta ttc cgg att gat cca gta aca ggt aac att     2686
 Gly Asn Asn Lys Gly Leu Phe Arg Ile Asp Pro Val Thr Gly Asn Ile
 720                 725                 730                 735

 act ctg gaa gaa aaa cca gca cct act gat gtg gga ttg cat cgt ttg     2734
 Thr Leu Glu Glu Lys Pro Ala Pro Thr Asp Val Gly Leu His Arg Leu
                 740                 745                 750

 gtg gtc aac ata agt gac ctg ggg tac cct aag tct ttg cac acg ctt     2782
 Val Val Asn Ile Ser Asp Leu Gly Tyr Pro Lys Ser Leu His Thr Leu
             755                 760                 765

 gtg ctt gta ttc ctt tat gtt aac gac act gct gga aat gcc tcc tat     2830
 Val Leu Val Phe Leu Tyr Val Asn Asp Thr Ala Gly Asn Ala Ser Tyr
         770                 775                 780

 atc tat gac ttg atc cgc agg act atg gag acc ccg ttg gac agg aac     2878
 Ile Tyr Asp Leu Ile Arg Arg Thr Met Glu Thr Pro Leu Asp Arg Asn
     785                 790                 795

 ata ggg gat agt agc caa ccc tat caa aat gag gac tat cta acc atc     2926
 Ile Gly Asp Ser Ser Gln Pro Tyr Gln Asn Glu Asp Tyr Leu Thr Ile
 800                 805                 810                 815

 atg att gcc atc atc gcc ggt gcc atg gtg gtc att gtt gtg atc ttc     2974
 Met Ile Ala Ile Ile Ala Gly Ala Met Val Val Ile Val Val Ile Phe
                 820                 825                 830

 gtc acc gtt ctg gtg cgc tgt cgc cat gca tca agg ttc aaa gca gct     3022
 Val Thr Val Leu Val Arg Cys Arg His Ala Ser Arg Phe Lys Ala Ala
             835                 840                 845

 cag agg agc aag caa ggt gcc gaa tgg atg tcc cca aac cag gag aac     3070
 Gln Arg Ser Lys Gln Gly Ala Glu Trp Met Ser Pro Asn Gln Glu Asn
         850                 855                 860

 aag caa aac aag aaa aag aaa aga aag aaa agg aag tct ccc aaa agc     3118
 Lys Gln Asn Lys Lys Lys Lys Arg Lys Lys Arg Lys Ser Pro Lys Ser
     865                 870                 875

 tct ctt ttg aac ttt gtt act atc gaa gag tcc aaa ccc gat gat gca     3166
 Ser Leu Leu Asn Phe Val Thr Ile Glu Glu Ser Lys Pro Asp Asp Ala
 880                 885                 890                 895

 gtt cat gaa cct atc aat ggg aca ata agc ctg ccg gct gaa ctg gag     3214
 Val His Glu Pro Ile Asn Gly Thr Ile Ser Leu Pro Ala Glu Leu Glu
                 900                 905                 910

 gag caa agt ata gga aga ttt gac tgg ggc ccg gca cct cca aca aca     3262
 Glu Gln Ser Ile Gly Arg Phe Asp Trp Gly Pro Ala Pro Pro Thr Thr
             915                 920                 925

 ttc aag cct aac agt cct gac ctg gcc aag cac tac aaa tct gct tct     3310
 Phe Lys Pro Asn Ser Pro Asp Leu Ala Lys His Tyr Lys Ser Ala Ser
         930                 935                 940

 cca cag cct gct ttt cat ctc aaa cca gac act cca gtt tcc gtg aaa     3358
 Pro Gln Pro Ala Phe His Leu Lys Pro Asp Thr Pro Val Ser Val Lys
     945                 950                 955

 aag cac cac gtg att cag gaa ctc cct ttg gac aac acc ttt gtt ggg     3406
 Lys His His Val Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Gly
 960                 965                 970                 975

 ggt tgt gac acc ctt tct aaa cgc tct tcc act agt tca gat cac ttc     3454
 Gly Cys Asp Thr Leu Ser Lys Arg Ser Ser Thr Ser Ser Asp His Phe
                 980                 985                 990

 agt gcc tca gag tgc agt tcc caa gga ggc ttc aag aca aag ggc ccc     3502
 Ser Ala Ser Glu Cys Ser Ser Gln Gly Gly Phe Lys Thr Lys Gly Pro
             995                1000                1005

 tta cac acc aga cag tcg cag cgc cgt gtt acg ttt cat ctc cct gat     3550
 Leu His Thr Arg Gln Ser Gln Arg Arg Val Thr Phe His Leu Pro Asp
        1010                1015                1020

 ggc tcc cag gaa agc tgc agt gac agt ggt cta gga gac cat gag ccg     3598
 Gly Ser Gln Glu Ser Cys Ser Asp Ser Gly Leu Gly Asp His Glu Pro
    1025                1030                1035

 gtg ggt agt gga acc ctg atc tca cac cct ctt cct ctg gtt cag cca     3646
 Val Gly Ser Gly Thr Leu Ile Ser His Pro Leu Pro Leu Val Gln Pro
1040                1045                1050                1055

 cag gac gaa ttc tat gac cag gcc tct ccg gac aag agg act gaa gca     3694
 Gln Asp Glu Phe Tyr Asp Gln Ala Ser Pro Asp Lys Arg Thr Glu Ala
                1060                1065                1070

 gat ggc aac tct gat ccc aac tct gat ggg cct ttg ggt ccc cga gga     3742
 Asp Gly Asn Ser Asp Pro Asn Ser Asp Gly Pro Leu Gly Pro Arg Gly
            1075                1080                1085

 tta gct gaa gct aca gag atg tgc act caa gag tgc ttg gtt ttg ggt     3790
 Leu Ala Glu Ala Thr Glu Met Cys Thr Gln Glu Cys Leu Val Leu Gly
        1090                1095                1100

 cac tct gat aat tgc tgg atg cct cct ggc ttg ggt cca tat caa cac     3838
 His Ser Asp Asn Cys Trp Met Pro Pro Gly Leu Gly Pro Tyr Gln His
    1105                1110                1115

 ccc aaa tct cct ctc tca acc ttt gca ccc cag aaa gaa tgg gtg aag     3886
 Pro Lys Ser Pro Leu Ser Thr Phe Ala Pro Gln Lys Glu Trp Val Lys
1120                1125                1130                1135

 aag gac aag ctt gtg aat ggg cac acc ctg acc aga gcc tgg aaa gaa     3934
 Lys Asp Lys Leu Val Asn Gly His Thr Leu Thr Arg Ala Trp Lys Glu
                1140                1145                1150

 gac agc aac agg aac cag ttc aat gac cgt aag cag tat ggc tcc aat     3982
 Asp Ser Asn Arg Asn Gln Phe Asn Asp Arg Lys Gln Tyr Gly Ser Asn
            1155                1160                1165

 gaa ggc cat ttc aac aat ggc agc cac atg aca gac att cct ctg gca     4030
 Glu Gly His Phe Asn Asn Gly Ser His Met Thr Asp Ile Pro Leu Ala
        1170                1175                1180

 aat ctg aag tct tat aag caa gca gga ggt gct act gag agt cct aag     4078
 Asn Leu Lys Ser Tyr Lys Gln Ala Gly Gly Ala Thr Glu Ser Pro Lys
    1185                1190                1195

 gag cac caa ctc taa gaaaaggcta tatgggacct aataacttta aatagacatg     4133
 Glu His Gln Leu 
1200

 ctaataccgt gtgcgtcaga gctttatgta ttcaatagat ctctacaact atgccccttc   4193

 tagcagggat acctataact ttgtgttagc accatggaga atacaatgtt tttgcaacat   4253

 atgagagaag atagttctag ccatgcaatt ttgtttacta gaattgatta cactctccag   4313

 agatctctcc attgtgcaaa ttttttttat tattgcattt tattttgacc ctggactgct   4373

 gctatgaaca atagaatatg catttggaaa gtaagaaagt ttcatggatt agagtgactg   4433

 aaaaacatat ccagttagaa aattgtgctt tttttttttt ttttttttgt cattgatttg   4493

 tgctgggact gctatacttg acattatact gcaaacaaaa cttaaagaga taagcattaa   4553

 acctattgtg ctgttaacaa cgttagtgga cacttgtaag tcaatcagtg ttaaagtatt   4613

 tgtaaataga agcaagctat tattaacaac ttttgtgtac ttataatgtt cacctaaaaa   4673

 tgttgtagca taattctgtg ttttatggtt gcttctgtcc ttctttttat ttacctcttt   4733

 gttgttattt ttgttgcttc tttcagtgag gtgtttctgt gttagtagtc tgtcttgaca   4793

 cacattgttc aaacaatctc aagcacttgt gtttaaaaaa ggttctgaaa tcttgcttct   4853

 catatgatag cttatgatgc cggaattctg taaacaataa agatgaaaga aaaaatgaaa   4913

 actttataca aaaaaggact tctgcaaaag cttggaaatt cagaacctat tttttatcat   4973

 cttattttca aagtaggcaa aagcaaaatc acttaattag caccattaag tgagagagta   5033

 atggaaaacg gttatccacc aaaagtgata taatatcctg tacttgtcac tcatgtaaaa   5093

 ctaatgtatc aaaattagca tatatggaag aaaaatcact attcaaaaat agtttcaatt   5153

 gggcaaatgt gtgtctacaa ctttgttgaa atggcacagt ctgtgttgat cctcatatac   5213

 aataatgttg ttgtaacaca agtgttatta gaccatagcc acaaaatatt taatgtgttg   5273

 tgccttcatg atgtaacaga acattctcca ggtagggtag ttgggggaaa taaagggata   5333

 aatctctaat tattgctgtt taactgtttg ttatcatagt tggtcaatgc ctggcaggta   5393

 ccagcatatt gtcacttagg tcaaaccaat aaagtggcaa ctaatgttaa taagatttca   5453

 gttgcacgtg caaacaaatc caaattcgaa cattcttaga aggtttttgt taaggcatga   5513

 cagatgattt aaacaaataa atagcatgca acaaaatgtc tttattgaaa gaagtggaag   5573

 ttatcttaat gccacggttc accatcaatt taaaagtaaa aaaaccaaaa aaaaaacaaa   5633

 aaatttaaaa aaaaggtttg ctaatctgat agttaatttg ttcttaccaa aaaataaaat   5693

 tactttgtaa atagcagttc acatttttcc acagtataat ggaaaataat gggtaggggt   5753

 gcattgctta ttgaagtaca tttttgtcgg tttgtgaggg gtgtttgatg actttgacag   5813

 aataaatatc taaacaatta tccttgttac tgctttgcca gttctacgtt atttacaatt   5873

 attcagctct tgcaataaat gttctgaatt accaaa                             5909




      <210> 59
      <211> 1765
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(1390)

      <400> 59
 agttcagaag ctcaaagcag ttgcaggtgt g   atg att act gcc tct cac aac      52
                                      Met Ile Thr Ala Ser His Asn
                                        1               5

 cgc aag gaa gac aat gga tac aag gtt tac tgg gaa act ggt gct cag      100
 Arg Lys Glu Asp Asn Gly Tyr Lys Val Tyr Trp Glu Thr Gly Ala Gln
          10                  15                  20

 atc aca tct cct cat gat aaa gaa att cta aaa tgt ata gaa gaa tgt      148
 Ile Thr Ser Pro His Asp Lys Glu Ile Leu Lys Cys Ile Glu Glu Cys
      25                  30                  35

 gtg gaa ccc tgg aat ggt tcc tgg aat gat aat tta gtg gat acc agc      196
 Val Glu Pro Trp Asn Gly Ser Trp Asn Asp Asn Leu Val Asp Thr Ser
  40                  45                  50                  55

 ccg ctg aag aga gac cct ctg cag gac att tgc agg aga tac atg gaa      244
 Pro Leu Lys Arg Asp Pro Leu Gln Asp Ile Cys Arg Arg Tyr Met Glu
                  60                  65                  70

 gat ctg aaa aag atc tgt ttt tac agg gag tta aac tcg aag acc acc      292
 Asp Leu Lys Lys Ile Cys Phe Tyr Arg Glu Leu Asn Ser Lys Thr Thr
              75                  80                  85

 ttg aaa ttt gtg cac aca tct ttt cat ggg gtc gga cat gac tat gtg      340
 Leu Lys Phe Val His Thr Ser Phe His Gly Val Gly His Asp Tyr Val
          90                  95                 100

 cag ttg gct ttt aaa gtg ttt ggt ttt aag cct cca att cca gta cca      388
 Gln Leu Ala Phe Lys Val Phe Gly Phe Lys Pro Pro Ile Pro Val Pro
     105                 110                 115

 gaa caa aaa gat cct gat cca gac ttt tct acc gtt aaa tgt cca aat      436
 Glu Gln Lys Asp Pro Asp Pro Asp Phe Ser Thr Val Lys Cys Pro Asn
 120                 125                 130                 135

 cct gaa gaa gga gaa tct gtg ctg gaa ctt tcc ttg aga ctg gca gag      484
 Pro Glu Glu Gly Glu Ser Val Leu Glu Leu Ser Leu Arg Leu Ala Glu
                 140                 145                 150

 aaa gaa aat gcc cgg gta gtg cta gcc aca gat cct gat gca gac aga      532
 Lys Glu Asn Ala Arg Val Val Leu Ala Thr Asp Pro Asp Ala Asp Arg
             155                 160                 165

 ctg gca gca gca gaa ctt cag gag aat ggt tgt tgg aaa gtt ttc aca      580
 Leu Ala Ala Ala Glu Leu Gln Glu Asn Gly Cys Trp Lys Val Phe Thr
         170                 175                 180

 ggg aat gag ttg gca gct ttg ttt gga tgg tgg atg ttt gat tgc tgg      628
 Gly Asn Glu Leu Ala Ala Leu Phe Gly Trp Trp Met Phe Asp Cys Trp
     185                 190                 195

 aag aaa aat aaa tca aga aat gct gat gtg aag aac gtt tat atg tta      676
 Lys Lys Asn Lys Ser Arg Asn Ala Asp Val Lys Asn Val Tyr Met Leu
 200                 205                 210                 215

 gcc acc aca gtc tct tct aaa att ctg aag gca att gca ctt aaa gaa      724
 Ala Thr Thr Val Ser Ser Lys Ile Leu Lys Ala Ile Ala Leu Lys Glu
                 220                 225                 230

 gga ttt cat ttt gaa gaa aca tta cca ggt ttt aaa tgg att gga agt      772
 Gly Phe His Phe Glu Glu Thr Leu Pro Gly Phe Lys Trp Ile Gly Ser
             235                 240                 245

 agg ata ata gac ctc ctg gaa aat ggg aaa gaa gtc ctt ttt gca ttt      820
 Arg Ile Ile Asp Leu Leu Glu Asn Gly Lys Glu Val Leu Phe Ala Phe
         250                 255                 260

 gaa gag tct att ggt ttt ctc tgt gga act tca gtt ttg gat aaa gat      868
 Glu Glu Ser Ile Gly Phe Leu Cys Gly Thr Ser Val Leu Asp Lys Asp
     265                 270                 275

 ggg gtg agt gca gct gtt gtg gtt gct gag atg gca tct tac ctg gaa      916
 Gly Val Ser Ala Ala Val Val Val Ala Glu Met Ala Ser Tyr Leu Glu
 280                 285                 290                 295

 acc atg aat ata aca ttg aaa cag caa ctg gtt aag gtt tat gaa aaa      964
 Thr Met Asn Ile Thr Leu Lys Gln Gln Leu Val Lys Val Tyr Glu Lys
                 300                 305                 310

 tat ggt tat cat att tca aaa act tcc tat ttc ttg tgt tat gaa cca     1012
 Tyr Gly Tyr His Ile Ser Lys Thr Ser Tyr Phe Leu Cys Tyr Glu Pro
             315                 320                 325

 cct acc atc aaa agt ata ttt gaa agg ctt cgt aat ttt gat tct cca     1060
 Pro Thr Ile Lys Ser Ile Phe Glu Arg Leu Arg Asn Phe Asp Ser Pro
         330                 335                 340

 aaa gaa tat cca aaa ttt tgt gga aca ttt gct ata ttg cat gta cgg     1108
 Lys Glu Tyr Pro Lys Phe Cys Gly Thr Phe Ala Ile Leu His Val Arg
     345                 350                 355

 gac gtt acc act gga tat gac agt agc cag cct aat aag aaa tca gtg     1156
 Asp Val Thr Thr Gly Tyr Asp Ser Ser Gln Pro Asn Lys Lys Ser Val
 360                 365                 370                 375

 ctg cct gtg agt aaa aac agc caa atg att aca ttt act ttt caa aat     1204
 Leu Pro Val Ser Lys Asn Ser Gln Met Ile Thr Phe Thr Phe Gln Asn
                 380                 385                 390

 ggc tgt gtt gct acc ctt cgg aca agt gga aca gaa cca aag ata aag     1252
 Gly Cys Val Ala Thr Leu Arg Thr Ser Gly Thr Glu Pro Lys Ile Lys
             395                 400                 405

 tat tat gca gag atg tgt gcg tca cct gac cag agt gac act gct tta     1300
 Tyr Tyr Ala Glu Met Cys Ala Ser Pro Asp Gln Ser Asp Thr Ala Leu
         410                 415                 420

 ctg gag gaa gaa ctg aag aaa ctc att gat gct ctg ata gag aat ttt     1348
 Leu Glu Glu Glu Leu Lys Lys Leu Ile Asp Ala Leu Ile Glu Asn Phe
     425                 430                 435

 ctt cag cct agt aag aat gga ctg atc tgg cgt tct gtt tag gggtaca     1397
 Leu Gln Pro Ser Lys Asn Gly Leu Ile Trp Arg Ser Val 
 440                 445                 450

 ccaatatgtc atgacactgt gtgggcatat ggaacagagc aaccgagaac tgcatacatt   1457

 gaaccttgtg ttagcattct ctctctatct catctggccg agtatctttt tccttttatt   1517

 ttctttcttt ttggtcaact ggctagacta aacaaagtat aagtttgaaa tgaaatggtc   1577

 tagagggaaa tgattcaaat tttttcataa ttcaaacaaa agttattaca ctaaaagtat   1637

 tatagtaacg tattgtcctt ccgttaacag aaacatcaca attcaaaagt gagttttctt   1697

 attatagtgt gattaagcct agttctgtat ctcgtaattg tgtatagcat ggtaaaaaaa   1757

 aaaaaaaa                                                            1765




      <210> 60
      <211> 3670
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (416)..(2767)

      <400> 60
 ctctgggaga ccgggatcct ggctgctcag cgggaaggca gcaggcaagt ggtctaacgt     60

 tggcggcggt ggcggtggcg gcggcggcgg caccgacagt aaagcgggga gcaagagaat    120

 ttgaaaagag acatccgctc cctctcacac gctgaggggg aggcattcgc gtttccccaa    180

 agtgagaaag aaccacaaga aatcatgaag taaaaacttt ggaaagctgc cactggagat    240

 gttgcacaaa aacctggaat cttttaggag tctcctccca gtcgttgaag gtttggggag    300

 cagctgatac agcaaggagg gctcttgcaa ggattcaagc tccgagccct ggaggagcag    360

 cacggagcgg gagagcgtgg cgagagaatg aagaaaccaa tcgcccggga gaagc atg     418
                                                              Met
                                                                1

 agg tgg cag tgt ggc act cgg ttt aga ggg ctt cgg ccg gcg gtg gcc      466
 Arg Trp Gln Cys Gly Thr Arg Phe Arg Gly Leu Arg Pro Ala Val Ala
               5                  10                  15

 cca tgg aca gcc ctg ctg gca ctg ggc ctg cct ggc tgg gtg ttg gct      514
 Pro Trp Thr Ala Leu Leu Ala Leu Gly Leu Pro Gly Trp Val Leu Ala
          20                  25                  30

 gtc tca gcc acg gcg gct gct gtg gtc ccc gag cag cat gcc tcc gta      562
 Val Ser Ala Thr Ala Ala Ala Val Val Pro Glu Gln His Ala Ser Val
      35                  40                  45

 gct ggc cag cat ccc ctg gac tgg ctg ctc aca gac cgg ggc ccc ttc      610
 Ala Gly Gln His Pro Leu Asp Trp Leu Leu Thr Asp Arg Gly Pro Phe
  50                  55                  60                  65

 cac cgc gct cag gag tat gct gac ttc atg gag cgg tac cgc cag ggt      658
 His Arg Ala Gln Glu Tyr Ala Asp Phe Met Glu Arg Tyr Arg Gln Gly
                  70                  75                  80

 ttc acc acc agg tac agg att tat agg gag ttt gcc cgt tgg aag gtg      706
 Phe Thr Thr Arg Tyr Arg Ile Tyr Arg Glu Phe Ala Arg Trp Lys Val
              85                  90                  95

 aac aac ttg gct ctg gaa agg aag gac ttc ttc agt ttg cca ttg cct      754
 Asn Asn Leu Ala Leu Glu Arg Lys Asp Phe Phe Ser Leu Pro Leu Pro
         100                 105                 110

 ctt gcc cca gag ttt atc cgg aac att cgc ctc ctt gga agg aga ccc      802
 Leu Ala Pro Glu Phe Ile Arg Asn Ile Arg Leu Leu Gly Arg Arg Pro
     115                 120                 125

 aat ctg caa cag gtt aca gaa aat ctg att aaa aag tac ggc act cat      850
 Asn Leu Gln Gln Val Thr Glu Asn Leu Ile Lys Lys Tyr Gly Thr His
 130                 135                 140                 145

 ttc tta ctt tct gcc acc ctt gga gga gaa gag tcc ctg acc att ttt      898
 Phe Leu Leu Ser Ala Thr Leu Gly Gly Glu Glu Ser Leu Thr Ile Phe
                 150                 155                 160

 gtg gac aag cag aaa ctg gga aga aag aca gag aca aca gga ggt gcc      946
 Val Asp Lys Gln Lys Leu Gly Arg Lys Thr Glu Thr Thr Gly Gly Ala
             165                 170                 175

 tct ata atc ggg ggc agt ggg aac agc aca gct gtg tcc ctg gag acc      994
 Ser Ile Ile Gly Gly Ser Gly Asn Ser Thr Ala Val Ser Leu Glu Thr
         180                 185                 190

 ctg cac cag ctg gcc gcc tct tac ttc atc gac aga gag agc acg ctg     1042
 Leu His Gln Leu Ala Ala Ser Tyr Phe Ile Asp Arg Glu Ser Thr Leu
     195                 200                 205

 cga cgg ctg cac cat atc cag ata gcc acg ggg gcc atc aag gtc acc     1090
 Arg Arg Leu His His Ile Gln Ile Ala Thr Gly Ala Ile Lys Val Thr
 210                 215                 220                 225

 gag acc agg acc ggt cct ctg ggc tgc agc aac tat gac aat ctg gac     1138
 Glu Thr Arg Thr Gly Pro Leu Gly Cys Ser Asn Tyr Asp Asn Leu Asp
                 230                 235                 240

 tca gtc agt tct gtc ttg gta cag agt cca gag aac aaa gta cag tta     1186
 Ser Val Ser Ser Val Leu Val Gln Ser Pro Glu Asn Lys Val Gln Leu
             245                 250                 255

 ctt ggc ctt cag gtg ctg ctg cct gag tat ctg cgt gag cgc ttt gta     1234
 Leu Gly Leu Gln Val Leu Leu Pro Glu Tyr Leu Arg Glu Arg Phe Val
         260                 265                 270

 gct gca gca ctc agc tac atc aca tgc agc tct gag ggt gag ctc gtc     1282
 Ala Ala Ala Leu Ser Tyr Ile Thr Cys Ser Ser Glu Gly Glu Leu Val
     275                 280                 285

 tgc aag gag aat gac tgc tgg tgc aag tgc agc ccc acc ttc cct gaa     1330
 Cys Lys Glu Asn Asp Cys Trp Cys Lys Cys Ser Pro Thr Phe Pro Glu
 290                 295                 300                 305

 tgc aac tgc cct gat gct gac atc cag gcc atg gag gac agc ctg ctg     1378
 Cys Asn Cys Pro Asp Ala Asp Ile Gln Ala Met Glu Asp Ser Leu Leu
                 310                 315                 320

 cag atc cag gac tcc tgg gcc act cac aac cgg cag ttt gaa gag tca     1426
 Gln Ile Gln Asp Ser Trp Ala Thr His Asn Arg Gln Phe Glu Glu Ser
             325                 330                 335

 gaa gag ttc cag gcc ctg ctg aaa agg ctg ccc gat gac cgg ttc ctg     1474
 Glu Glu Phe Gln Ala Leu Leu Lys Arg Leu Pro Asp Asp Arg Phe Leu
         340                 345                 350

 aac tcc aca gct atc tcc cag ttc tgg gcc atg gac acc agc ctt cag     1522
 Asn Ser Thr Ala Ile Ser Gln Phe Trp Ala Met Asp Thr Ser Leu Gln
     355                 360                 365

 cac cgc tac cag cag ctg gga gct ggc ttg aaa gtg ctg ttc aaa aag     1570
 His Arg Tyr Gln Gln Leu Gly Ala Gly Leu Lys Val Leu Phe Lys Lys
 370                 375                 380                 385

 acc cat cgg atc cta cgc cgg ctc ttc aac ctc tgc aag cgc tgc cat     1618
 Thr His Arg Ile Leu Arg Arg Leu Phe Asn Leu Cys Lys Arg Cys His
                 390                 395                 400

 cgc cag cct cgc ttc cgc ctg ccc aag gag agg tcc ttg tcc tac tgg     1666
 Arg Gln Pro Arg Phe Arg Leu Pro Lys Glu Arg Ser Leu Ser Tyr Trp
             405                 410                 415

 tgg aac cga atc cag tcc ctc ctc tac tgt ggg gaa agc acc ttt cct     1714
 Trp Asn Arg Ile Gln Ser Leu Leu Tyr Cys Gly Glu Ser Thr Phe Pro
         420                 425                 430

 ggc act ttc ctg gaa cag agc cac agc tgc acc tgc ccc tat gac caa     1762
 Gly Thr Phe Leu Glu Gln Ser His Ser Cys Thr Cys Pro Tyr Asp Gln
     435                 440                 445

 tct tcc tgc cag ggc ccc atc cca tgt gcc ttg ggc gaa ggg ccc gcg     1810
 Ser Ser Cys Gln Gly Pro Ile Pro Cys Ala Leu Gly Glu Gly Pro Ala
 450                 455                 460                 465

 tgt gcc cac tgt gct cca gac aat agc aca cgc tgt ggg agc tgc aac     1858
 Cys Ala His Cys Ala Pro Asp Asn Ser Thr Arg Cys Gly Ser Cys Asn
                 470                 475                 480

 ccg ggc tat gtg ctg gcc cag ggg ctg tgc cgg cca gag gtg gcc gag     1906
 Pro Gly Tyr Val Leu Ala Gln Gly Leu Cys Arg Pro Glu Val Ala Glu
             485                 490                 495

 tcc ctg gaa aac ttt ctt ggg ctg gag aca gac ttg cag gac ctg gag     1954
 Ser Leu Glu Asn Phe Leu Gly Leu Glu Thr Asp Leu Gln Asp Leu Glu
         500                 505                 510

 cta aag tac ctg ctg cag aag cag gat agc cgc att gag gta cac tcc     2002
 Leu Lys Tyr Leu Leu Gln Lys Gln Asp Ser Arg Ile Glu Val His Ser
     515                 520                 525

 atc ttc atc agc aat gac atg cgg ctg ggc agc tgg ttt gac cct tcc     2050
 Ile Phe Ile Ser Asn Asp Met Arg Leu Gly Ser Trp Phe Asp Pro Ser
 530                 535                 540                 545

 tgg agg aag cgc atg ctg ctc acc ctg aag agc aac aag tac aag cct     2098
 Trp Arg Lys Arg Met Leu Leu Thr Leu Lys Ser Asn Lys Tyr Lys Pro
                 550                 555                 560

 ggg ctg gtg cac gtg atg ttg gcc ttg tcc ttg cag atc tgt ctc acc     2146
 Gly Leu Val His Val Met Leu Ala Leu Ser Leu Gln Ile Cys Leu Thr
             565                 570                 575

 aag aac agc acc ctg gag cct gtc atg gcc atc tac gtc aac ccc ttt     2194
 Lys Asn Ser Thr Leu Glu Pro Val Met Ala Ile Tyr Val Asn Pro Phe
         580                 585                 590

 ggg ggc agc cac tct gag agc tgg ttc atg cct gtg aat gag ggc agc     2242
 Gly Gly Ser His Ser Glu Ser Trp Phe Met Pro Val Asn Glu Gly Ser
     595                 600                 605

 ttt cct gac tgg gaa agg act aac gtg gat gca gct gcc cag tgc caa     2290
 Phe Pro Asp Trp Glu Arg Thr Asn Val Asp Ala Ala Ala Gln Cys Gln
 610                 615                 620                 625

 aac tgg act atc acc ttg ggg aat agg tgg aag act ttc ttt gag aca     2338
 Asn Trp Thr Ile Thr Leu Gly Asn Arg Trp Lys Thr Phe Phe Glu Thr
                 630                 635                 640

 gtt cat gtt tac cta cgg agc cga atc aag tcc ctg gat gac agc tcc     2386
 Val His Val Tyr Leu Arg Ser Arg Ile Lys Ser Leu Asp Asp Ser Ser
             645                 650                 655

 aat gag aca atc tac tat gag ccc ctg gag atg act gat ccc tct aag     2434
 Asn Glu Thr Ile Tyr Tyr Glu Pro Leu Glu Met Thr Asp Pro Ser Lys
         660                 665                 670

 aat ttg ggt tac atg aaa att aac acc ttg cag gtc ttt ggc tac agc     2482
 Asn Leu Gly Tyr Met Lys Ile Asn Thr Leu Gln Val Phe Gly Tyr Ser
     675                 680                 685

 ctg ccc ttt gac cca gat gct atc cgg gac tta att ctc cag ttg gac     2530
 Leu Pro Phe Asp Pro Asp Ala Ile Arg Asp Leu Ile Leu Gln Leu Asp
 690                 695                 700                 705

 tac cca tat act caa ggt tcc cag gac tct gca ctc ttg cag ctc att     2578
 Tyr Pro Tyr Thr Gln Gly Ser Gln Asp Ser Ala Leu Leu Gln Leu Ile
                 710                 715                 720

 gag ctc agg gac cgg gtg aac cag ctt tct cca cct ggc aaa gtc cga     2626
 Glu Leu Arg Asp Arg Val Asn Gln Leu Ser Pro Pro Gly Lys Val Arg
             725                 730                 735

 ctt gac ctt ttc tcc tgc ttg ctc cgg cat cgg ctt aag ctg gcc aac     2674
 Leu Asp Leu Phe Ser Cys Leu Leu Arg His Arg Leu Lys Leu Ala Asn
         740                 745                 750

 aat gag gtg ggc agg atc cag tcc tcc ctg agg gct ttc aat tct aag     2722
 Asn Glu Val Gly Arg Ile Gln Ser Ser Leu Arg Ala Phe Asn Ser Lys
     755                 760                 765

 ctg cca aac cct gtg gaa tat gag acc ggc aaa ctc tgt agc taa tgg     2770
 Leu Pro Asn Pro Val Glu Tyr Glu Thr Gly Lys Leu Cys Ser 
 770                 775                 780

 gcggcccact tcagcactgg gcaaggaggg gatccatgaa tctggggtac aaagataatc   2830

 taagccctca ccttagtgcc aacagggtgt gctcccacga gactttcagc atccagtaga   2890

 tgggacctcg aggctcgagc tgaagcaggc gagagagaaa cagctactgc gtgcgtgcgc   2950

 gcacgcatac acacacacac acacacactg gcacagggag gctacaacta agcagcctca   3010

 gatctgtaaa gttgattggt gctttctaaa atgaatgcaa ttgaaagaaa ggagccaagg   3070

 aagagattaa gaaaaagaac cagctgaacc atgaaacaaa caaaaatcct aaaagtgatt   3130

 cttgtcattc aagaaagcaa gaggggacaa caatgggagg ggtcggagct cttccttccc   3190

 ctctgtggag tcacttttgt attcttttta accagatttc ttaaaatgtt gttgttttgt   3250

 gaatcctgac attggttctt acttttgtat gctgcctcct ctgtgccctc ccagacgctg   3310

 actgggaaac acaagaagta caaccaacag gaaccagcgc caagggcagg cagcggcctc   3370

 cttgctcccc tcccttactc ctccctctgc tgcctcctcc ccccaccaag tttcagggcc   3430

 ctggattgtt cccagttccc attgtggtcc cttcagagct cctttccaac agcatctctc   3490

 tgtcgaagaa agaagctctg tcaagttaga gagagacaat gtgtaggaaa tgttcttttt   3550

 taaaaaaaaa taacaaaaac aaaacaaaac tatttatttt gtgattgttt tccttgttaa   3610

 tctgctccaa ccacctgaac atctaagtaa acatttatct ggtttaatat aaaaaaaaaa   3670




      <210> 61
      <211> 1991
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(1891)

      <400> 61
 ggaattaccg ttttacttac gtggactcga cgacctcata cctgtgagtg aatatttggt     60

 actgagagtc accaacccca ttgtggactg ggtctaccaa atagagagac tatgt atg     118
                                                              Met
                                                                1

 caa ttt tca aac atg cct att ggt tat aga gat tca aca cct caa cag      166
 Gln Phe Ser Asn Met Pro Ile Gly Tyr Arg Asp Ser Thr Pro Gln Gln
               5                  10                  15

 tgg gct gta tcc atg agg aaa gat ggc aag ttt tac tgt cag ttg gtt      214
 Trp Ala Val Ser Met Arg Lys Asp Gly Lys Phe Tyr Cys Gln Leu Val
          20                  25                  30

 ata tgt tct cat ttt gct caa gac ctt tgg cca gag cag ggc aga gaa      262
 Ile Cys Ser His Phe Ala Gln Asp Leu Trp Pro Glu Gln Gly Arg Glu
      35                  40                  45

 gat tct ttc caa aaa gtg ata ttg aga aga tat gaa aaa tgt gga cat      310
 Asp Ser Phe Gln Lys Val Ile Leu Arg Arg Tyr Glu Lys Cys Gly His
  50                  55                  60                  65

 gag aat tta cag tta aaa att ggt tgt acc aat gtg gat gag tgt aat      358
 Glu Asn Leu Gln Leu Lys Ile Gly Cys Thr Asn Val Asp Glu Cys Asn
                  70                  75                  80

 ctg cac aaa gaa tgt tat gat gaa cta aac cag tgt ttg aca act acc      406
 Leu His Lys Glu Cys Tyr Asp Glu Leu Asn Gln Cys Leu Thr Thr Thr
              85                  90                  95

 cag agt gaa ata ttt caa tat gat aaa tat gtg aat gtc ttt tat aaa      454
 Gln Ser Glu Ile Phe Gln Tyr Asp Lys Tyr Val Asn Val Phe Tyr Lys
         100                 105                 110

 ttt tca aat cca aat ata caa aag ata aga cat act gga aag aag cct      502
 Phe Ser Asn Pro Asn Ile Gln Lys Ile Arg His Thr Gly Lys Lys Pro
     115                 120                 125

 ttc aaa tgt aaa aaa tgt gac aaa tcg ttt tgc atg ctt tta cac cta      550
 Phe Lys Cys Lys Lys Cys Asp Lys Ser Phe Cys Met Leu Leu His Leu
 130                 135                 140                 145

 act caa cat aaa aga att cat att agg gaa aat tct tac caa tgt gaa      598
 Thr Gln His Lys Arg Ile His Ile Arg Glu Asn Ser Tyr Gln Cys Glu
                 150                 155                 160

 gaa tgt ggt aaa gtc ttt aac tgg ttc tca acc ctt act aga cac aga      646
 Glu Cys Gly Lys Val Phe Asn Trp Phe Ser Thr Leu Thr Arg His Arg
             165                 170                 175

 aga att cat act gga gag aaa ccc tac aaa tgt gaa caa tgt ggc aaa      694
 Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Gln Cys Gly Lys
         180                 185                 190

 gct ttt aag cag tcc tca acc ctt act aca cat aag ata att cat act      742
 Ala Phe Lys Gln Ser Ser Thr Leu Thr Thr His Lys Ile Ile His Thr
     195                 200                 205

 gga gag aaa ccc tac aga tgt gaa gaa tgt ggc aaa acc ttt aac cgg      790
 Gly Glu Lys Pro Tyr Arg Cys Glu Glu Cys Gly Lys Thr Phe Asn Arg
 210                 215                 220                 225

 tcc tca cac ctt act aca cat aaa aga att cat act gga gag aaa ccc      838
 Ser Ser His Leu Thr Thr His Lys Arg Ile His Thr Gly Glu Lys Pro
                 230                 235                 240

 tac aga tgt gaa gaa tgt ggc aga gct ttt aac cgg tcc tca cac ctt      886
 Tyr Arg Cys Glu Glu Cys Gly Arg Ala Phe Asn Arg Ser Ser His Leu
             245                 250                 255

 act aca cat aag att att cat act gga gag aaa ccc tac aaa tgt gaa      934
 Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
         260                 265                 270

 gaa tgt ggc aaa gct ttt aac caa tcc tca acc ctt act aca cat aag      982
 Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser Thr Leu Thr Thr His Lys
     275                 280                 285

 ata att cat gct gga gag aaa cct tac aaa tgt gaa gaa tgt ggc aaa     1030
 Ile Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
 290                 295                 300                 305

 gct ttt tac cga ttc tca tac ctt act aaa cat aag ata att cat act     1078
 Ala Phe Tyr Arg Phe Ser Tyr Leu Thr Lys His Lys Ile Ile His Thr
                 310                 315                 320

 gga gag aaa ttc tac aaa tgt gaa gaa tgt ggc aaa ggc ttt aat tgg     1126
 Gly Glu Lys Phe Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Asn Trp
             325                 330                 335

 tcc tcg acc ctt act aaa cat aaa aga att cat act gga gag aaa ccc     1174
 Ser Ser Thr Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro
         340                 345                 350

 tac aaa tgt gaa caa tgt ggc aaa gct ttt aat gag tcc tca aac ctt     1222
 Tyr Lys Cys Glu Gln Cys Gly Lys Ala Phe Asn Glu Ser Ser Asn Leu
     355                 360                 365

 act gca cat aag ata att cat act gga gag aaa ccc tac aaa tgt gaa     1270
 Thr Ala His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
 370                 375                 380                 385

 gaa tgt ggc aaa gcc ttt aac cgg tcc cca aaa ctt act gca cat aag     1318
 Glu Cys Gly Lys Ala Phe Asn Arg Ser Pro Lys Leu Thr Ala His Lys
                 390                 395                 400

 gta att cat tct gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa     1366
 Val Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
             405                 410                 415

 gct ttt aac caa ttc tca aac ctt act aaa cat aag ata act cat att     1414
 Ala Phe Asn Gln Phe Ser Asn Leu Thr Lys His Lys Ile Thr His Ile
         420                 425                 430

 gga gat aca tct tac aaa tac cta gaa tgt gat aaa gcc ttt agc cag     1462
 Gly Asp Thr Ser Tyr Lys Tyr Leu Glu Cys Asp Lys Ala Phe Ser Gln
     435                 440                 445

 tct tca act ctt act aaa cat aag gta att cat act gga gag aaa ccc     1510
 Ser Ser Thr Leu Thr Lys His Lys Val Ile His Thr Gly Glu Lys Pro
 450                 455                 460                 465

 tac aac tgt gaa gaa tac ggc aaa gct ttc aac cag tcc tca aac ctt     1558
 Tyr Asn Cys Glu Glu Tyr Gly Lys Ala Phe Asn Gln Ser Ser Asn Leu
                 470                 475                 480

 att gaa caa aag gaa ccc tat gag tgt gaa gaa tgt ggc aaa gcc ttc     1606
 Ile Glu Gln Lys Glu Pro Tyr Glu Cys Glu Glu Cys Gly Lys Ala Phe
             485                 490                 495

 aac cag tcc tca atc ctt act aca cat agg aga att cat act gga gag     1654
 Asn Gln Ser Ser Ile Leu Thr Thr His Arg Arg Ile His Thr Gly Glu
         500                 505                 510

 aaa ttc tac aaa tgt gaa gaa tgt ggc aaa gct ttt aag tgc tcc tct     1702
 Lys Phe Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Cys Ser Ser
     515                 520                 525

 aac ctt act aca cat aag aaa att cat act gga gag aga ccc tac aaa     1750
 Asn Leu Thr Thr His Lys Lys Ile His Thr Gly Glu Arg Pro Tyr Lys
 530                 535                 540                 545

 tgt gaa gaa tgt ggc aaa gcc ttc aac cag tcc tca atc ctt act aca     1798
 Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser Ile Leu Thr Thr
                 550                 555                 560

 cat gag aga atc ata ctg gag aga aat tct aca aat gtg aag aat gtg     1846
 His Glu Arg Ile Ile Leu Glu Arg Asn Ser Thr Asn Val Lys Asn Val
             565                 570                 575

 gca aag cct tca agc ggt cct cac acc tta cta cac ata aga taa ttc     1894
 Ala Lys Pro Ser Ser Gly Pro His Thr Leu Leu His Ile Arg 
         580                 585                 590

 atactggaga gaaattctac aaatgtgaat aatgtgacac agcttttaag catttctcta   1954

 accttactac acataagaaa attcatactg gaaaaaa                            1991




      <210> 62
      <211> 2299
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (162)..(1874)

      <400> 62
 tttttggcgg ggcctttgtc cctcgctgtg gcctgagctc caggtctcgt cttcagcgct     60

 ctgtgtcctc tgctcctaga ggtccaggct ctgtggccct gtgacctgca ggtattggga    120

 gatctacagc taagacgcca ggaacccctg gaagcctaga a    atg gag aac ctg     173
                                                  Met Glu Asn Leu
                                                    1

 aag tct gga gtg tat cct ctc aag gaa gca agt gga tgc cct ggg gct      221
 Lys Ser Gly Val Tyr Pro Leu Lys Glu Ala Ser Gly Cys Pro Gly Ala
   5                  10                  15                  20

 gac agg aat ctt ctg gtg tac tct ttt tat gaa aag ggg cca ttg aca      269
 Asp Arg Asn Leu Leu Val Tyr Ser Phe Tyr Glu Lys Gly Pro Leu Thr
                  25                  30                  35

 ttt agg gat gtg gcc ata gaa ttt tct ctg gag gag tgg caa tgc ctg      317
 Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu Glu Trp Gln Cys Leu
              40                  45                  50

 gac act gct cag cag gat ttg tat aga aaa gtg atg tta gag aac tac      365
 Asp Thr Ala Gln Gln Asp Leu Tyr Arg Lys Val Met Leu Glu Asn Tyr
          55                  60                  65

 aga aac ctg gtc ttc ttg gca ggt att gct gtt tct aag cca gac ctg      413
 Arg Asn Leu Val Phe Leu Ala Gly Ile Ala Val Ser Lys Pro Asp Leu
      70                  75                  80

 atc acc tgt cta gag caa gga aaa gag ccc tgg aat atg aag aga cat      461
 Ile Thr Cys Leu Glu Gln Gly Lys Glu Pro Trp Asn Met Lys Arg His
  85                  90                  95                 100

 gcg atg gta gat caa ccc cca gtt aca tat tct cat ttt gcc caa gac      509
 Ala Met Val Asp Gln Pro Pro Val Thr Tyr Ser His Phe Ala Gln Asp
                 105                 110                 115

 ctt tgg cca gag cag ggc ata aaa gat tct ttc caa gaa gtc ata ttg      557
 Leu Trp Pro Glu Gln Gly Ile Lys Asp Ser Phe Gln Glu Val Ile Leu
             120                 125                 130

 aga aga tat gga aaa tgt gga cat gaa gat tta cag tta aga aca ggc      605
 Arg Arg Tyr Gly Lys Cys Gly His Glu Asp Leu Gln Leu Arg Thr Gly
         135                 140                 145

 tgt aga agt gtg gat gag tgt aat ctg cac aaa gaa tgt tat gat gaa      653
 Cys Arg Ser Val Asp Glu Cys Asn Leu His Lys Glu Cys Tyr Asp Glu
     150                 155                 160

 cta aac cag tgt ttg aca act acc cag agt gaa ata ttt caa tat gat      701
 Leu Asn Gln Cys Leu Thr Thr Thr Gln Ser Glu Ile Phe Gln Tyr Asp
 165                 170                 175                 180

 aaa tat gtg aat gtc ttt tat aaa ttt tca aat cca aat ata caa aag      749
 Lys Tyr Val Asn Val Phe Tyr Lys Phe Ser Asn Pro Asn Ile Gln Lys
                 185                 190                 195

 ata aga cat act gga aag aag cct ttc aaa tgt aaa aaa tgt gac aaa      797
 Ile Arg His Thr Gly Lys Lys Pro Phe Lys Cys Lys Lys Cys Asp Lys
             200                 205                 210

 tcg ttt tgc atg ctt tta cac cta act caa cat aaa aga att cat att      845
 Ser Phe Cys Met Leu Leu His Leu Thr Gln His Lys Arg Ile His Ile
         215                 220                 225

 agg gaa aat tct tac caa tgt gaa gaa tgt ggt aaa gtc ttt aac tgg      893
 Arg Glu Asn Ser Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Asn Trp
     230                 235                 240

 ttc tca acc ctt act aga cac aga aga att cat act gga gag aaa ccc      941
 Phe Ser Thr Leu Thr Arg His Arg Arg Ile His Thr Gly Glu Lys Pro
 245                 250                 255                 260

 tac aaa tgt gaa caa tgt ggc aaa gct ttt aag cag tcc tca acc ctt      989
 Tyr Lys Cys Glu Gln Cys Gly Lys Ala Phe Lys Gln Ser Ser Thr Leu
                 265                 270                 275

 act aca cat aag ata att cat act gga gag aaa ccc tac aga tgt gaa     1037
 Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Glu
             280                 285                 290

 gaa tgt ggc aaa acc ttt aac cgg tcc tca cac ctt act aca cat aaa     1085
 Glu Cys Gly Lys Thr Phe Asn Arg Ser Ser His Leu Thr Thr His Lys
         295                 300                 305

 aga att cat act gga gag aaa ccc tac aga tgt gaa gaa tgt ggc aga     1133
 Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Glu Glu Cys Gly Arg
     310                 315                 320

 gct ttt aac cgg tcc tca cac ctt act aca cat aag att att cat act     1181
 Ala Phe Asn Arg Ser Ser His Leu Thr Thr His Lys Ile Ile His Thr
 325                 330                 335                 340

 gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa gct ttt aac caa     1229
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln
                 345                 350                 355

 tcc tca acc ctt act aca cat aag ata att cat gct gga gag aaa cct     1277
 Ser Ser Thr Leu Thr Thr His Lys Ile Ile His Ala Gly Glu Lys Pro
             360                 365                 370

 tac aaa tgt gaa gaa tgt ggc aaa gct ttt tac cga ttc tca tac ctt     1325
 Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Tyr Arg Phe Ser Tyr Leu
         375                 380                 385

 act aaa cat aag ata att cat act gga gag aaa ttc tac aaa tgt gaa     1373
 Thr Lys His Lys Ile Ile His Thr Gly Glu Lys Phe Tyr Lys Cys Glu
     390                 395                 400

 gaa tgt ggc aaa ggc ttt aat tgg tcc tcg acc ctt act aaa cat aaa     1421
 Glu Cys Gly Lys Gly Phe Asn Trp Ser Ser Thr Leu Thr Lys His Lys
 405                 410                 415                 420

 aga att cat act gga gag aaa ccc tac aaa tgt gaa caa tgt ggc aaa     1469
 Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Gln Cys Gly Lys
                 425                 430                 435

 gct ttt aat gag tcc tca aac ctt act gca cat aag ata att cat act     1517
 Ala Phe Asn Glu Ser Ser Asn Leu Thr Ala His Lys Ile Ile His Thr
             440                 445                 450

 gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa gcc ttt aac cgg     1565
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg
         455                 460                 465

 tcc cca aaa ctt act gca cat aag gta att cat tct gga gag aaa ccc     1613
 Ser Pro Lys Leu Thr Ala His Lys Val Ile His Ser Gly Glu Lys Pro
     470                 475                 480

 tac aaa tgt gaa gaa tgt ggc aaa gct ttt aac caa ttc tca aac ctt     1661
 Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Phe Ser Asn Leu
 485                 490                 495                 500

 act aaa cat aag ata act cat att gga gat aca tct tac aaa tac cta     1709
 Thr Lys His Lys Ile Thr His Ile Gly Asp Thr Ser Tyr Lys Tyr Leu
                 505                 510                 515

 gaa tgt gat aaa gcc ttt agc cag tct tca act ctt act aaa cat aag     1757
 Glu Cys Asp Lys Ala Phe Ser Gln Ser Ser Thr Leu Thr Lys His Lys
             520                 525                 530

 gta att cat act gga gag aaa ccc tac aac tgt gaa gaa tac ggc aaa     1805
 Val Ile His Thr Gly Glu Lys Pro Tyr Asn Cys Glu Glu Tyr Gly Lys
         535                 540                 545

 gct ttc aac cag tcc tca aac ctt att gaa caa agt aat tca tac tgg     1853
 Ala Phe Asn Gln Ser Ser Asn Leu Ile Glu Gln Ser Asn Ser Tyr Trp
     550                 555                 560

 aga gaa acc cta caa atg tga ag attgtggcaa agcctctaac ccgtcctgaa     1906
 Arg Glu Thr Leu Gln Met 
 565                 570

 ttcttactaa acataagaac attcatactg aagaggaacc ctatgagtgt gaagaatatg   1966

 gcaaagcctt caacaagtcc tcaattctta ccagacataa gataattctg gctgggtgcg   2026

 gtggctcaca cctgtaatcc cagcactttg ggaggctgag acgggtgaat tacatgaggt   2086

 tgggagttcg agaccagcct gaccaacatg gtgaaatcct gtctctacta aaaatacaaa   2146

 attagccatg cgtagtggtg catgcctgta atcccagcta ctcgggaggc tgaggcagga   2206

 gaattgcttg aacccgggag gcagaggttg aagtgagctg agatcgcgcc attgcactcc   2266

 agcctgggca acaagagtgg cactccatct cag                                2299




      <210> 63
      <211> 606
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(606)

      <400> 63
  atg gtg acg ctt gct gaa ctg ctg gtg ctc ctg gcc gct ctc ctg gcc      48
  Met Val Thr Leu Ala Glu Leu Leu Val Leu Leu Ala Ala Leu Leu Ala
    1               5                  10                  15

 acg gtc tcg ggc tat ttc gtt agc atc gac gcc cat gct gaa gag tgc       96
 Thr Val Ser Gly Tyr Phe Val Ser Ile Asp Ala His Ala Glu Glu Cys
              20                  25                  30

 ttc ttt gag cgg gtc acc tcg ggc acc aag atg ggc ctc atc ttc gag      144
 Phe Phe Glu Arg Val Thr Ser Gly Thr Lys Met Gly Leu Ile Phe Glu
          35                  40                  45

 gtg gcg gag ggc ggc ttc ctg gac atc gac gtg gag att aca gga cca      192
 Val Ala Glu Gly Gly Phe Leu Asp Ile Asp Val Glu Ile Thr Gly Pro
      50                  55                  60

 gat aac aaa ggc att tac aaa gga gac aga gaa tcc agt ggg aaa tac      240
 Asp Asn Lys Gly Ile Tyr Lys Gly Asp Arg Glu Ser Ser Gly Lys Tyr
  65                  70                  75                  80

 aca ttt gct gct cac atg gat gga aca tac aaa ttt tgt ttt agt atc      288
 Thr Phe Ala Ala His Met Asp Gly Thr Tyr Lys Phe Cys Phe Ser Ile
                  85                  90                  95

 cgg atg tcc gcc atg act cca aaa ata gtg atg ttc acc att gat att      336
 Arg Met Ser Ala Met Thr Pro Lys Ile Val Met Phe Thr Ile Asp Ile
             100                 105                 110

 ggg gag gct cca aaa gga caa gat atg gaa aca gaa gct cac cag aac      384
 Gly Glu Ala Pro Lys Gly Gln Asp Met Glu Thr Glu Ala His Gln Asn
         115                 120                 125

 aag cta gaa gaa atg atc aat gag cta gca gtg gcg atg aca gct gta      432
 Lys Leu Glu Glu Met Ile Asn Glu Leu Ala Val Ala Met Thr Ala Val
     130                 135                 140

 aag cac gaa cag gaa tac atg gaa gtc cgg gag aga ata cac aga gcc      480
 Lys His Glu Gln Glu Tyr Met Glu Val Arg Glu Arg Ile His Arg Ala
 145                 150                 155                 160

 atc aac gac aac aca aac agc aga gtg gtc ctt tgg tcc ttc ttt gaa      528
 Ile Asn Asp Asn Thr Asn Ser Arg Val Val Leu Trp Ser Phe Phe Glu
                 165                 170                 175

 gct ctt gtt cta gtt gcc atg aca ttg gga cag atc tac tac ctg aag      576
 Ala Leu Val Leu Val Ala Met Thr Leu Gly Gln Ile Tyr Tyr Leu Lys
             180                 185                 190

 aga ttt ttt gaa gtc cgg aga gtt gtt taa                              606
 Arg Phe Phe Glu Val Arg Arg Val Val 
         195                 200





      <210> 64
      <211> 1569
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (9)..(1229)

      <400> 64
 caacggtg atg gcg ggc aag cgg tcc ggc tgg agc cgg gcg gct ctc ctc      50
          Met Ala Gly Lys Arg Ser Gly Trp Ser Arg Ala Ala Leu Leu
            1               5                  10

 cag ctc ctt ctc ggc gtg aac ctg gtg gtg atg ccg ccc acc cgg gcc       98
 Gln Leu Leu Leu Gly Val Asn Leu Val Val Met Pro Pro Thr Arg Ala
  15                  20                  25                  30

 cgg agt ctg cgc ttc gtt acc ttg ctg tac cgc cat gga gac cgt tca      146
 Arg Ser Leu Arg Phe Val Thr Leu Leu Tyr Arg His Gly Asp Arg Ser
                  35                  40                  45

 cca gtg aag aca tat ccc aag gac ccc tat cag gaa gaa gaa tgg ccc      194
 Pro Val Lys Thr Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Glu Trp Pro
              50                  55                  60

 cag ggg ttt ggt cag tta acc aag gag ggg atg cta cag cac tgg gaa      242
 Gln Gly Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His Trp Glu
          65                  70                  75

 ctg ggc cag gcc ctg cgg cag cgc tat cac ggc ttc cta aac acc tct      290
 Leu Gly Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn Thr Ser
      80                  85                  90

 tat cac cgg caa gag gtt tat gtg cga agc aca gac ttt gac cgg act      338
 Tyr His Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp Arg Thr
  95                 100                 105                 110

 ctc atg agt gct gag gcc aac ctg gct gga ctc ttc cct ccc aac ggg      386
 Leu Met Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro Asn Gly
                 115                 120                 125

 atg cag cgc ttc aac ccg aac atc tcg tgg cag cct att cct gtg cac      434
 Met Gln Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His
             130                 135                 140

 act gtg ccc atc act gag gac agg ctg ctg aag ttc ccg ttg ggc cca      482
 Thr Val Pro Ile Thr Glu Asp Arg Leu Leu Lys Phe Pro Leu Gly Pro
         145                 150                 155

 tgt ccc cgt tat gag cag ctg cag aac gag acc cgg cag aca cca gag      530
 Cys Pro Arg Tyr Glu Gln Leu Gln Asn Glu Thr Arg Gln Thr Pro Glu
     160                 165                 170

 tat cag aat gag agt tct cgg aat gca caa ttt ctg gac atg gtg gcc      578
 Tyr Gln Asn Glu Ser Ser Arg Asn Ala Gln Phe Leu Asp Met Val Ala
 175                 180                 185                 190

 aac gag aca ggg ctt aca gac ctg aca ctg gag acc gtc tgg aat gtc      626
 Asn Glu Thr Gly Leu Thr Asp Leu Thr Leu Glu Thr Val Trp Asn Val
                 195                 200                 205

 tat gac aca ctc ttc tgt gag caa acg cac ggg ctg cgc ctg ccg ccc      674
 Tyr Asp Thr Leu Phe Cys Glu Gln Thr His Gly Leu Arg Leu Pro Pro
             210                 215                 220

 tgg gcc tca ccc caa acc atg cag cgt ctc agc cgg cta aag gac ttc      722
 Trp Ala Ser Pro Gln Thr Met Gln Arg Leu Ser Arg Leu Lys Asp Phe
         225                 230                 235

 agc ttc cgc ttc ctc ttc gga atc tac cag cag gcg gag aag gcc cgg      770
 Ser Phe Arg Phe Leu Phe Gly Ile Tyr Gln Gln Ala Glu Lys Ala Arg
     240                 245                 250

 ctt cag ggg gga gtc ctg ctg gct cag ata agg aag aac ctg acc cta      818
 Leu Gln Gly Gly Val Leu Leu Ala Gln Ile Arg Lys Asn Leu Thr Leu
 255                 260                 265                 270

 atg gcg acc acc tcc cag ctc ccc aag ctg ctg gtt tac tct gcg cac      866
 Met Ala Thr Thr Ser Gln Leu Pro Lys Leu Leu Val Tyr Ser Ala His
                 275                 280                 285

 gac act acc ctg gtt gcc ctg caa atg gca ctg gat gtc tac aat ggt      914
 Asp Thr Thr Leu Val Ala Leu Gln Met Ala Leu Asp Val Tyr Asn Gly
             290                 295                 300

 gaa caa gcc ccc tac gcc tcc tgc cac ata ttt gaa ctg tac cag gaa      962
 Glu Gln Ala Pro Tyr Ala Ser Cys His Ile Phe Glu Leu Tyr Gln Glu
         305                 310                 315

 gat tct ggg aat ttc tca gtg gag atg tac ttt cgg aac gag agt gac     1010
 Asp Ser Gly Asn Phe Ser Val Glu Met Tyr Phe Arg Asn Glu Ser Asp
     320                 325                 330

 aag gcc ccc tgg ccg ctc agc ctg cct ggc tgc cct cac cgc tgc cca     1058
 Lys Ala Pro Trp Pro Leu Ser Leu Pro Gly Cys Pro His Arg Cys Pro
 335                 340                 345                 350

 ctg cag gac ttc ctt cgc ctc aca gag ccc gtc gtg ccc aag gat tgg     1106
 Leu Gln Asp Phe Leu Arg Leu Thr Glu Pro Val Val Pro Lys Asp Trp
                 355                 360                 365

 cag cag gag tgc cag ctg gca agc ggt cct gca gac aca gtg ctg ctc     1154
 Gln Gln Glu Cys Gln Leu Ala Ser Gly Pro Ala Asp Thr Val Leu Leu
             370                 375                 380

 ctc acc gtc ctc ttc cgg atg cag gcc cag cct cct ggc tac cgc cac     1202
 Leu Thr Val Leu Phe Arg Met Gln Ala Gln Pro Pro Gly Tyr Arg His
         385                 390                 395

 gtc gca gat ggg gag gac cac gcc tga caacc actcagcccc cttccctcca     1254
 Val Ala Asp Gly Glu Asp His Ala 
     400                 405

 cctcctaggg gaggtgggct gggccctcgc tcctgactgt tgctgctccc cagcccatgg   1314

 acaggagatc ctgggttggg cctccctctg atgaccccag ccagatgagc gagtggggct   1374

 cagcgtggcc catggtgcct gtcactcagc attcccatgc ctgatgttta ccaagtgctg   1434

 tgttggacac tggctttctc caaacaggat ttgcctcctc cacgctccct acacacctga   1494

 gatgtaaact ggcagtcagt gttcactcag gacctaggat tagaaaatgg cagagttggt   1554

 gctggatcca ccttg                                                    1569




      <210> 65
      <211> 2877
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2877)

      <400> 65
  atg ccc cgg ggg ttg gaa caa aag acg ctc ctg ccc tgt gcg gcc gcc      48
  Met Pro Arg Gly Leu Glu Gln Lys Thr Leu Leu Pro Cys Ala Ala Ala
    1               5                  10                  15

 ccg ggc gtg tac acc tgc gtg aac tac atg ttc aca gac gtg tgc aca       96
 Pro Gly Val Tyr Thr Cys Val Asn Tyr Met Phe Thr Asp Val Cys Thr
              20                  25                  30

 agt gtg cat cgg ctt tgc ttg gtg gac att tgg caa acg aca atg gag      144
 Ser Val His Arg Leu Cys Leu Val Asp Ile Trp Gln Thr Thr Met Glu
          35                  40                  45

 gca aag aaa cct ctc tgc atc ccc aag tgc gca cct gcg cag ccc cac      192
 Ala Lys Lys Pro Leu Cys Ile Pro Lys Cys Ala Pro Ala Gln Pro His
      50                  55                  60

 tgt cag gct gtc ctg gtg gga gtg ggc tct gag gag gat ggc cta ccc      240
 Cys Gln Ala Val Leu Val Gly Val Gly Ser Glu Glu Asp Gly Leu Pro
  65                  70                  75                  80

 gtc ttt cca gcg gac cat gcc gct tgc agc tgt gag gtt ggg gga gcc      288
 Val Phe Pro Ala Asp His Ala Ala Cys Ser Cys Glu Val Gly Gly Ala
                  85                  90                  95

 ggg ggc gtc tct ccc cag ctg gtc tgg gtc ctc ctg gtg ctg cca gga      336
 Gly Gly Val Ser Pro Gln Leu Val Trp Val Leu Leu Val Leu Pro Gly
             100                 105                 110

 ccg aga gca gct gcc cta ctg ccc cca ccc tgt ccc aca gtg cat ggg      384
 Pro Arg Ala Ala Ala Leu Leu Pro Pro Pro Cys Pro Thr Val His Gly
         115                 120                 125

 tgc cag acc tgg atg ggc tgc agt agt gca gtg ggg gcg acc att gac      432
 Cys Gln Thr Trp Met Gly Cys Ser Ser Ala Val Gly Ala Thr Ile Asp
     130                 135                 140

 gag gtg gag acg gac gtg gtg gag att gag gcc aaa ctg gac aag ctg      480
 Glu Val Glu Thr Asp Val Val Glu Ile Glu Ala Lys Leu Asp Lys Leu
 145                 150                 155                 160

 gtg aag ctg tgc agt ggc atg gtg gaa gcc ggt aag gcc tac gtc agc      528
 Val Lys Leu Cys Ser Gly Met Val Glu Ala Gly Lys Ala Tyr Val Ser
                 165                 170                 175

 acc agc agg ctt ttc gtg agc ggc gtc cgc gac ctg tcc cag cag tgc      576
 Thr Ser Arg Leu Phe Val Ser Gly Val Arg Asp Leu Ser Gln Gln Cys
             180                 185                 190

 cag ggc gac acc gtc atc tcg gaa tgt ctg cag agg ttc gct gac agc      624
 Gln Gly Asp Thr Val Ile Ser Glu Cys Leu Gln Arg Phe Ala Asp Ser
         195                 200                 205

 cta cag gag gtg gtg aac tac cac atg atc ctg ttt gac cag gcc cag      672
 Leu Gln Glu Val Val Asn Tyr His Met Ile Leu Phe Asp Gln Ala Gln
     210                 215                 220

 agg tcc gtg cgg cag cag ctc cag agc ttt gtc aaa gag gat gtg cgg      720
 Arg Ser Val Arg Gln Gln Leu Gln Ser Phe Val Lys Glu Asp Val Arg
 225                 230                 235                 240

 aag ttc aag gag aca aag aag cag ttt gac aag gtg cgg gag gac ctg      768
 Lys Phe Lys Glu Thr Lys Lys Gln Phe Asp Lys Val Arg Glu Asp Leu
                 245                 250                 255

 gag ctg tcc ctg gtg agg aac gcc cag gcc ccg agg cac cgg ccc cac      816
 Glu Leu Ser Leu Val Arg Asn Ala Gln Ala Pro Arg His Arg Pro His
             260                 265                 270

 gag gtg gag gaa gcc acc ggg gcc ctc acc ctc acc agg aag tgc ttc      864
 Glu Val Glu Glu Ala Thr Gly Ala Leu Thr Leu Thr Arg Lys Cys Phe
         275                 280                 285

 cgc cac ctg gca ctg gac tat gtg ctc cag atc aat gtt ctg cag gcc      912
 Arg His Leu Ala Leu Asp Tyr Val Leu Gln Ile Asn Val Leu Gln Ala
     290                 295                 300

 aag aag aag ttt gag atc ctg gac tct atg ctg tcc ttc atg cac gcc      960
 Lys Lys Lys Phe Glu Ile Leu Asp Ser Met Leu Ser Phe Met His Ala
 305                 310                 315                 320

 cag tcc agc ttc ttc cag cag ggc tac agc ctc ctg cac cag ctg gac     1008
 Gln Ser Ser Phe Phe Gln Gln Gly Tyr Ser Leu Leu His Gln Leu Asp
                 325                 330                 335

 ccc tac atg aag aag ctg gca gcc gag ctg gac cag ctg gtg atc gac     1056
 Pro Tyr Met Lys Lys Leu Ala Ala Glu Leu Asp Gln Leu Val Ile Asp
             340                 345                 350

 tct gcg gtg gaa aag cgt gag atg gag cga aag cac gcc gcc atc cag     1104
 Ser Ala Val Glu Lys Arg Glu Met Glu Arg Lys His Ala Ala Ile Gln
         355                 360                 365

 cag cgg acg ctg ctg cag gac ttc tcc tac gat gag tcc aaa gtg gag     1152
 Gln Arg Thr Leu Leu Gln Asp Phe Ser Tyr Asp Glu Ser Lys Val Glu
     370                 375                 380

 ttt gac gtg gac gcg ccc agt ggg gtg gtg atg gag ggc tac ctc ttc     1200
 Phe Asp Val Asp Ala Pro Ser Gly Val Val Met Glu Gly Tyr Leu Phe
 385                 390                 395                 400

 aag agg gcc agc aac gct ttc aag aca tgg aac cgg cgc tgg ttc tcc     1248
 Lys Arg Ala Ser Asn Ala Phe Lys Thr Trp Asn Arg Arg Trp Phe Ser
                 405                 410                 415

 att cag aac agc cag ctg gtc tac cag aag aag ctc aag gat gcc ctc     1296
 Ile Gln Asn Ser Gln Leu Val Tyr Gln Lys Lys Leu Lys Asp Ala Leu
             420                 425                 430

 acc gtg gtg gtg gat gac ctc cgc ctg tgc tct gtg aag ccg tgt gag     1344
 Thr Val Val Val Asp Asp Leu Arg Leu Cys Ser Val Lys Pro Cys Glu
         435                 440                 445

 gac atc gag cgg agg ttc tgc ttc gag gtg ctg tca ccc acc aag agc     1392
 Asp Ile Glu Arg Arg Phe Cys Phe Glu Val Leu Ser Pro Thr Lys Ser
     450                 455                 460

 tgc atg ctg cag gct gac tcc gag aag ctg cgg caa gcc tgg gtc cag     1440
 Cys Met Leu Gln Ala Asp Ser Glu Lys Leu Arg Gln Ala Trp Val Gln
 465                 470                 475                 480

 gct gtg cag gcc agc atc gcc tcc gcc tac cgc gag agc cct gac agt     1488
 Ala Val Gln Ala Ser Ile Ala Ser Ala Tyr Arg Glu Ser Pro Asp Ser
                 485                 490                 495

 tgc tat agc gag agg ctg gac cgc aca gca tcc ccg tcc acg agc agc     1536
 Cys Tyr Ser Glu Arg Leu Asp Arg Thr Ala Ser Pro Ser Thr Ser Ser
             500                 505                 510

 atc gac tcc gcc acc gac act cgg gag cgt ggc gtg aag ggc gag agt     1584
 Ile Asp Ser Ala Thr Asp Thr Arg Glu Arg Gly Val Lys Gly Glu Ser
         515                 520                 525

 gtg ctg cag cgt gtg cag agt gtg gcc ggc aac agc cag tgc ggc gac     1632
 Val Leu Gln Arg Val Gln Ser Val Ala Gly Asn Ser Gln Cys Gly Asp
     530                 535                 540

 tgc ggc cag ccg gac ccc cgc tgg gcc agc atc aac ctg ggc gtg ctg     1680
 Cys Gly Gln Pro Asp Pro Arg Trp Ala Ser Ile Asn Leu Gly Val Leu
 545                 550                 555                 560

 ctc tgc att gag tgc tcc ggc atc cac agg agc ttg ggt gtc cac tgc     1728
 Leu Cys Ile Glu Cys Ser Gly Ile His Arg Ser Leu Gly Val His Cys
                 565                 570                 575

 tcc aag gtg cgg tcc ctg acg ctg gac tcg tgg gag cct gag ctg cta     1776
 Ser Lys Val Arg Ser Leu Thr Leu Asp Ser Trp Glu Pro Glu Leu Leu
             580                 585                 590

 aag ctg atg tgt gag ctt gga aac agc gct gtg aat cag atc tat gag     1824
 Lys Leu Met Cys Glu Leu Gly Asn Ser Ala Val Asn Gln Ile Tyr Glu
         595                 600                 605

 gcc cag tgt gag ggt gca ggc agc agg aaa ccc aca gcc agc agc tcc     1872
 Ala Gln Cys Glu Gly Ala Gly Ser Arg Lys Pro Thr Ala Ser Ser Ser
     610                 615                 620

 cgg cag gac aag gag gcc tgg atc aag gac aaa tac gtg gaa aag aag     1920
 Arg Gln Asp Lys Glu Ala Trp Ile Lys Asp Lys Tyr Val Glu Lys Lys
 625                 630                 635                 640

 ttt ctg cgg aag gcg ccc atg gca cca gcc ctg gag gcc cca aga cgc     1968
 Phe Leu Arg Lys Ala Pro Met Ala Pro Ala Leu Glu Ala Pro Arg Arg
                 645                 650                 655

 tgg agg gtg cag aag tgc ctg cgg ccc cac agc tct ccc cgc gct ccc     2016
 Trp Arg Val Gln Lys Cys Leu Arg Pro His Ser Ser Pro Arg Ala Pro
             660                 665                 670

 act gcc cgc cgc aag gtc cgg ctt gag ccc gtt ctg ccc tgt gtg gcc     2064
 Thr Ala Arg Arg Lys Val Arg Leu Glu Pro Val Leu Pro Cys Val Ala
         675                 680                 685

 gct ctg tcc tca gtg ggc acc ctg gat cgt aag ttc cgc cga gac tcc     2112
 Ala Leu Ser Ser Val Gly Thr Leu Asp Arg Lys Phe Arg Arg Asp Ser
     690                 695                 700

 ctc ttc tgt ccc gac gag ctg gac tcg ctc ttc tcc tac ttc gac gca     2160
 Leu Phe Cys Pro Asp Glu Leu Asp Ser Leu Phe Ser Tyr Phe Asp Ala
 705                 710                 715                 720

 ggg gcc gca ggg gct ggc cct cgc agt ctg agt agc gac agt ggc ctt     2208
 Gly Ala Ala Gly Ala Gly Pro Arg Ser Leu Ser Ser Asp Ser Gly Leu
                 725                 730                 735

 ggg ggc agc tcg gat ggc agc tcg gac gtc ctg gct ttc ggc tcg ggc     2256
 Gly Gly Ser Ser Asp Gly Ser Ser Asp Val Leu Ala Phe Gly Ser Gly
             740                 745                 750

 tct gtg gtg gac agc gtc act gag gag gag ggt gca gag tcg gag gag     2304
 Ser Val Val Asp Ser Val Thr Glu Glu Glu Gly Ala Glu Ser Glu Glu
         755                 760                 765

 tcc agc ggt gag gca gac ggg gac act gag gcc gag gcc tgg ggc ctg     2352
 Ser Ser Gly Glu Ala Asp Gly Asp Thr Glu Ala Glu Ala Trp Gly Leu
     770                 775                 780

 gcg gac gtg cgc gag ctg cac ccg ggg ctc ttg gcg cac cgc gca gcg     2400
 Ala Asp Val Arg Glu Leu His Pro Gly Leu Leu Ala His Arg Ala Ala
 785                 790                 795                 800

 cgt gcc cgc gac ctt cct gcg ctg gcg gcg gcg ctg gcc cac ggg gcc     2448
 Arg Ala Arg Asp Leu Pro Ala Leu Ala Ala Ala Leu Ala His Gly Ala
                 805                 810                 815

 gag gtc aac tgg gcg gac gcg gag gat gag ggc aag acg ccg ctg gtg     2496
 Glu Val Asn Trp Ala Asp Ala Glu Asp Glu Gly Lys Thr Pro Leu Val
             820                 825                 830

 cag gcc gtg cta ggg ggc tcc ttg atc gtc tgt gag ttc ctg ctg caa     2544
 Gln Ala Val Leu Gly Gly Ser Leu Ile Val Cys Glu Phe Leu Leu Gln
         835                 840                 845

 aac gga gcg gac gtg aac caa aga gac agc cgg ggc cgg gcg ccc ctg     2592
 Asn Gly Ala Asp Val Asn Gln Arg Asp Ser Arg Gly Arg Ala Pro Leu
     850                 855                 860

 cac cac gcc acg ctg ctg ggc cgc acc ggc cag gtt tgc ctg ttc ctg     2640
 His His Ala Thr Leu Leu Gly Arg Thr Gly Gln Val Cys Leu Phe Leu
 865                 870                 875                 880

 aag cgg ggc gcg gac cag cac gcc ctg gac caa gag cag cgg gac ccg     2688
 Lys Arg Gly Ala Asp Gln His Ala Leu Asp Gln Glu Gln Arg Asp Pro
                 885                 890                 895

 ttg gcc atc gca gtg cag gcg gcc aac gct gac atc gtg aca ctg ctc     2736
 Leu Ala Ile Ala Val Gln Ala Ala Asn Ala Asp Ile Val Thr Leu Leu
             900                 905                 910

 cgt ctg gcg cgc atg gcg gag gaa atg cgc gag gcc gag gct gcc cct     2784
 Arg Leu Ala Arg Met Ala Glu Glu Met Arg Glu Ala Glu Ala Ala Pro
         915                 920                 925

 ggt ccc ccg ggc gcc ctg gcg ggc agc ccc acg gag ctc cag ttc cgc     2832
 Gly Pro Pro Gly Ala Leu Ala Gly Ser Pro Thr Glu Leu Gln Phe Arg
     930                 935                 940

 agg tgt atc cag gag ttc atc agc ctc cac ctg gaa gag agc tag         2877
 Arg Cys Ile Gln Glu Phe Ile Ser Leu His Leu Glu Glu Ser 
 945                 950                 955





      <210> 66
      <211> 1463
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (126)..(677)

      <400> 66
 gcggcccatt gattgattgc atgagcatat aactatctat tcgatgatga agatacccca     60

 ccaaacccaa aaaaagagat ctctcgagga tccgaattcg cggccgcgtc gaccttcgcg    120

 caggg    atg gag ccg gaa gag ggg acg ccc ttg tgg cgg ctg cag aag     167
          Met Glu Pro Glu Glu Gly Thr Pro Leu Trp Arg Leu Gln Lys
            1               5                  10

 ctg ccg gcc gag ctg ggc ccg cag ctt ctt cac aaa ata att gat ggc      215
 Leu Pro Ala Glu Leu Gly Pro Gln Leu Leu His Lys Ile Ile Asp Gly
  15                  20                  25                  30

 att tgt ggt cga gct tat cct gtg tac caa gat tat cac act gtt tgg      263
 Ile Cys Gly Arg Ala Tyr Pro Val Tyr Gln Asp Tyr His Thr Val Trp
                  35                  40                  45

 gaa tca gaa gaa tgg atg cac gtt tta gaa gat att gcc aaa ttt ttc      311
 Glu Ser Glu Glu Trp Met His Val Leu Glu Asp Ile Ala Lys Phe Phe
              50                  55                  60

 aaa gcc ata gtt ggt aaa aac tta cct gat gaa gag ata ttt cag cag      359
 Lys Ala Ile Val Gly Lys Asn Leu Pro Asp Glu Glu Ile Phe Gln Gln
          65                  70                  75

 ttg aat cag ttg aat tca ctt cat caa gaa act atc atg aaa tgc gtg      407
 Leu Asn Gln Leu Asn Ser Leu His Gln Glu Thr Ile Met Lys Cys Val
      80                  85                  90

 aaa agt agg aaa gat gaa atc aaa cag gct ctg tca aga gaa ata gtt      455
 Lys Ser Arg Lys Asp Glu Ile Lys Gln Ala Leu Ser Arg Glu Ile Val
  95                 100                 105                 110

 gct att tcc tct gca cag cta cag gat ttt gat tgg cag gta aag ctt      503
 Ala Ile Ser Ser Ala Gln Leu Gln Asp Phe Asp Trp Gln Val Lys Leu
                 115                 120                 125

 gca ctt tcc agt gac aag att gct gca tta cga atg cca ctt tta agc      551
 Ala Leu Ser Ser Asp Lys Ile Ala Ala Leu Arg Met Pro Leu Leu Ser
             130                 135                 140

 ctg cat cta gat gta aaa gaa aat ggt gaa gta aaa cct tat tct att      599
 Leu His Leu Asp Val Lys Glu Asn Gly Glu Val Lys Pro Tyr Ser Ile
         145                 150                 155

 gaa atg agt aga gag gag ctg cag aat cta ata cag tcc ttg gaa gca      647
 Glu Met Ser Arg Glu Glu Leu Gln Asn Leu Ile Gln Ser Leu Glu Ala
     160                 165                 170

 gcg aat aag gtg gtc ctg cag ttg aaa taa c tggaaatgat gaataccagt      698
 Ala Asn Lys Val Val Leu Gln Leu Lys 
 175                 180

 cctatcagat tttattgctc caacttatat ggcagagtga atactgcgtg ttcagaaacc    758

 ttgtgatgtc ttgactgttg caccaggctg agaaagcagc aatattgata ttataaagat    818

 aaaaatttat caacattcct taacaggaaa ttacatggtt gagaggaaat gcataaaatg    878

 aaagatgaaa aatctatagt agcagtttat attttcatga ttgttttgcc tcatttatta    938

 aatatttgag aaatctttgg agatacatag ttttattgaa agctaaaaat aggttctaaa    998

 gtaatgtaaa aatataaagc acaaatatac ttgaatattg cttaaagaat tgtgtgaata   1058

 gcaacatata ttatggatat atactttgtg atatttttaa aaaataattt tttcaaagaa   1118

 tgtataagct gcatatataa ctcaggagat tccatgtctt tctcatattt cagaggaaag   1178

 attataaaat ataaaatttc ttagagaaca cctctttgtc agagataaac aagaacaaat   1238

 actctaaact tatgtgaaca gttttgagtt tatgaattct agaaactaaa atcaagaata   1298

 cagaaaaatg aaaataacat tttacttctg cgcttctatg tttgggaaac attgctctga   1358

 taaaaaatag ctgtcattat gcagtgtgta tattcaaata tgagataaga ctatgtacac   1418

 atccactttt gttaataaac tcaatattga ataaaaaaaa aaaaa                   1463




      <210> 67
      <211> 2466
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (10)..(2451)

      <400> 67
 agcgggtgt    atg aga ggc gca ggg atc ggc ggg agg aag gct gtc gga      48
              Met Arg Gly Ala Gly Ile Gly Gly Arg Lys Ala Val Gly
                1               5                  10

 gcc aat caa gcc gcc tcc aga ccc cgg cac gtc gcc tgg gct gcg cgc       96
 Ala Asn Gln Ala Ala Ser Arg Pro Arg His Val Ala Trp Ala Ala Arg
      15                  20                  25

 tcc gac tgc gcc tcc gcc cgc gcg cct ccc ggc ctc gcc cga ggg tgc      144
 Ser Asp Cys Ala Ser Ala Arg Ala Pro Pro Gly Leu Ala Arg Gly Cys
  30                  35                  40                  45

 ctg ggc agg cga gga ccc cag gtt cag cag ctg gac atg gag aac caa      192
 Leu Gly Arg Arg Gly Pro Gln Val Gln Gln Leu Asp Met Glu Asn Gln
                  50                  55                  60

 cgc tca tca cct ctg tcg ttc ccc agt gtt cca caa gaa gaa acc tta      240
 Arg Ser Ser Pro Leu Ser Phe Pro Ser Val Pro Gln Glu Glu Thr Leu
              65                  70                  75

 cgt cag gcc cct gct gga ctc ccc cga gaa act ctg ttc caa tcc cgc      288
 Arg Gln Ala Pro Ala Gly Leu Pro Arg Glu Thr Leu Phe Gln Ser Arg
          80                  85                  90

 gtt ctt cct ccc aaa gaa att cct tct ttg tct ccc acc att ccc cgt      336
 Val Leu Pro Pro Lys Glu Ile Pro Ser Leu Ser Pro Thr Ile Pro Arg
      95                 100                 105

 caa ggc tcc ctg ccc caa act tcc agt gct ccc aag caa gag act tct      384
 Gln Gly Ser Leu Pro Gln Thr Ser Ser Ala Pro Lys Gln Glu Thr Ser
 110                 115                 120                 125

 ggc cgg atg cca cat gtg ctc cag aag gga ccc tca ctc ctg tgt tct      432
 Gly Arg Met Pro His Val Leu Gln Lys Gly Pro Ser Leu Leu Cys Ser
                 130                 135                 140

 gcc gct tct gag caa gag act tct ctc cag ggc ccc ctg gct tcc cag      480
 Ala Ala Ser Glu Gln Glu Thr Ser Leu Gln Gly Pro Leu Ala Ser Gln
             145                 150                 155

 gaa ggg acc cag tat cca ccc cca gct gct gct gaa caa gaa gtc tcc      528
 Glu Gly Thr Gln Tyr Pro Pro Pro Ala Ala Ala Glu Gln Glu Val Ser
         160                 165                 170

 ctt ctc tcc cac tcc ccc cac cac cag gaa gcc ccc gtt cac tcc cct      576
 Leu Leu Ser His Ser Pro His His Gln Glu Ala Pro Val His Ser Pro
     175                 180                 185

 gaa gct cct gag aaa gac ccc ctg acc ctt tcc cca aca gtt ccc gag      624
 Glu Ala Pro Glu Lys Asp Pro Leu Thr Leu Ser Pro Thr Val Pro Glu
 190                 195                 200                 205

 act gac atg gac ccg ctg ctc cag agc ccg gtt tcc caa aag gac acc      672
 Thr Asp Met Asp Pro Leu Leu Gln Ser Pro Val Ser Gln Lys Asp Thr
                 210                 215                 220

 cct ttc cag atc tct tct gca gtc cag aag gaa cag ccg ctc ccc acg      720
 Pro Phe Gln Ile Ser Ser Ala Val Gln Lys Glu Gln Pro Leu Pro Thr
             225                 230                 235

 gca gag atc acc cgc ttg gct gtg tgg gct gcc gtc caa gca gtg gag      768
 Ala Glu Ile Thr Arg Leu Ala Val Trp Ala Ala Val Gln Ala Val Glu
         240                 245                 250

 agg aag ctg gag gcc cag gcc atg agg cta ctg acc ctg gaa ggc agg      816
 Arg Lys Leu Glu Ala Gln Ala Met Arg Leu Leu Thr Leu Glu Gly Arg
     255                 260                 265

 acg ggg aca aat gaa aag aag ata gcc gac tgc gag aag aca gcc gtg      864
 Thr Gly Thr Asn Glu Lys Lys Ile Ala Asp Cys Glu Lys Thr Ala Val
 270                 275                 280                 285

 gag ttc gcg aac cat ctg gag agc aag tgg gtc gtg ttg ggg acc ctg      912
 Glu Phe Ala Asn His Leu Glu Ser Lys Trp Val Val Leu Gly Thr Leu
                 290                 295                 300

 ctg cag gag tat ggg ctg ctg cag agg cgg ctg gag aac atg gag aac      960
 Leu Gln Glu Tyr Gly Leu Leu Gln Arg Arg Leu Glu Asn Met Glu Asn
             305                 310                 315

 ctg ctg aaa aac aga aat ttc tgg atc ctg cgg ctg ccc ccc ggc agc     1008
 Leu Leu Lys Asn Arg Asn Phe Trp Ile Leu Arg Leu Pro Pro Gly Ser
         320                 325                 330

 aat gga gaa gtt ccc aag gtc cct gtc aca ttt gat gat gtt gct gtg     1056
 Asn Gly Glu Val Pro Lys Val Pro Val Thr Phe Asp Asp Val Ala Val
     335                 340                 345

 cac ttc tcg gag cag gag tgg gga aac ctg tct gag tgg cag aag gag     1104
 His Phe Ser Glu Gln Glu Trp Gly Asn Leu Ser Glu Trp Gln Lys Glu
 350                 355                 360                 365

 ctc tac aag aac gtg atg agg ggc aac tac gag tcc ctg gtt tcc atg     1152
 Leu Tyr Lys Asn Val Met Arg Gly Asn Tyr Glu Ser Leu Val Ser Met
                 370                 375                 380

 gac tat gca att tcc aaa cca gac ctc atg tca cag atg gag cgc ggg     1200
 Asp Tyr Ala Ile Ser Lys Pro Asp Leu Met Ser Gln Met Glu Arg Gly
             385                 390                 395

 gag cgg ccc acc atg cag gag cag gaa gac tct gag gag ggc gaa acg     1248
 Glu Arg Pro Thr Met Gln Glu Gln Glu Asp Ser Glu Glu Gly Glu Thr
         400                 405                 410

 ccg aca gat ccc agt gct gcg cac gat ggg atc gtg att aag atc gag     1296
 Pro Thr Asp Pro Ser Ala Ala His Asp Gly Ile Val Ile Lys Ile Glu
     415                 420                 425

 gta cag acc aac gac gag ggc tca gaa agt ttg gag aca cct gag ccc     1344
 Val Gln Thr Asn Asp Glu Gly Ser Glu Ser Leu Glu Thr Pro Glu Pro
 430                 435                 440                 445

 ctg atg gga cag gtg gaa gag cac ggc ttc cag gac tca gag ctg ggt     1392
 Leu Met Gly Gln Val Glu Glu His Gly Phe Gln Asp Ser Glu Leu Gly
                 450                 455                 460

 gac ccc tgt ggg gaa cag cca gac ctg gac atg cag gag cca gag aac     1440
 Asp Pro Cys Gly Glu Gln Pro Asp Leu Asp Met Gln Glu Pro Glu Asn
             465                 470                 475

 acg ctg gag gag tcc acg gaa ggc tcc agc gag ttc agc gaa ctg aag     1488
 Thr Leu Glu Glu Ser Thr Glu Gly Ser Ser Glu Phe Ser Glu Leu Lys
         480                 485                 490

 cag atg ctg gtg cag cag agg aac tgc acg gag ggg atc gtg atc aag     1536
 Gln Met Leu Val Gln Gln Arg Asn Cys Thr Glu Gly Ile Val Ile Lys
     495                 500                 505

 aca gag gaa caa gac gag gag gaa gaa gag gag gag gag gat gag ctg     1584
 Thr Glu Glu Gln Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Leu
 510                 515                 520                 525

 ccg cag cac ttg caa tcc ctt ggg cag ctg tcc ggg aga tat gag gcc     1632
 Pro Gln His Leu Gln Ser Leu Gly Gln Leu Ser Gly Arg Tyr Glu Ala
                 530                 535                 540

 agt atg tac cag acc ccg ctg ccc ggg gag atg tcc ccc gag ggc gag     1680
 Ser Met Tyr Gln Thr Pro Leu Pro Gly Glu Met Ser Pro Glu Gly Glu
             545                 550                 555

 gag agc ccc ccg ccc ctg cag cta gga aac ccc gca gtg aaa agg ctg     1728
 Glu Ser Pro Pro Pro Leu Gln Leu Gly Asn Pro Ala Val Lys Arg Leu
         560                 565                 570

 gcg ccc tcc gtg cac ggt gag cgg cac ctg agc gag aac cgc ggg gcc     1776
 Ala Pro Ser Val His Gly Glu Arg His Leu Ser Glu Asn Arg Gly Ala
     575                 580                 585

 tcg agc cag cag cag cgg aac cgg cgc ggc gag cgg ccc ttc aca tgc     1824
 Ser Ser Gln Gln Gln Arg Asn Arg Arg Gly Glu Arg Pro Phe Thr Cys
 590                 595                 600                 605

 atg gag tgc ggc aag agc ttc cgc ctg aag atc aac ctc atc atc cac     1872
 Met Glu Cys Gly Lys Ser Phe Arg Leu Lys Ile Asn Leu Ile Ile His
                 610                 615                 620

 cag cgc aac cac atc aag gag ggg ccc tac gag tgc gcc gaa tgc gag     1920
 Gln Arg Asn His Ile Lys Glu Gly Pro Tyr Glu Cys Ala Glu Cys Glu
             625                 630                 635

 atc agc ttc cgg cac aag caa cag ctc acg ctg cac cag cgc atc cac     1968
 Ile Ser Phe Arg His Lys Gln Gln Leu Thr Leu His Gln Arg Ile His
         640                 645                 650

 cgc gtg cgc gga ggc tgc gtc tca ccc gaa cgc ggg ccc acg ttc aac     2016
 Arg Val Arg Gly Gly Cys Val Ser Pro Glu Arg Gly Pro Thr Phe Asn
     655                 660                 665

 ccc aag cac gcg ctc aag ccg cgt ccc aag tca ccc agc tct ggt agc     2064
 Pro Lys His Ala Leu Lys Pro Arg Pro Lys Ser Pro Ser Ser Gly Ser
 670                 675                 680                 685

 ggc ggc ggt ggc cct aag ccc tac aag tgc ccc gag tgc gac agc agc     2112
 Gly Gly Gly Gly Pro Lys Pro Tyr Lys Cys Pro Glu Cys Asp Ser Ser
                 690                 695                 700

 ttc agc cac aag tcc agc ctg acc aaa cac cag atc acg cac acg ggt     2160
 Phe Ser His Lys Ser Ser Leu Thr Lys His Gln Ile Thr His Thr Gly
             705                 710                 715

 gag cgg ccc tac acg tgc ccc gag tgc aag aag agc ttc cgc ctg cac     2208
 Glu Arg Pro Tyr Thr Cys Pro Glu Cys Lys Lys Ser Phe Arg Leu His
         720                 725                 730

 atc agc ttg gtg atc cat cag cgc gtg cac gcg ggc aag cat gag gtc     2256
 Ile Ser Leu Val Ile His Gln Arg Val His Ala Gly Lys His Glu Val
     735                 740                 745

 tcc ttc atc tgc agc ctg tgc ggc aag agc ttc agc cgc ccc tcg cac     2304
 Ser Phe Ile Cys Ser Leu Cys Gly Lys Ser Phe Ser Arg Pro Ser His
 750                 755                 760                 765

 ctg ctg cgc cac cag cgg act cac aca ggc gag cgg ccc ttc aag tgc     2352
 Leu Leu Arg His Gln Arg Thr His Thr Gly Glu Arg Pro Phe Lys Cys
                 770                 775                 780

 ccc gag tgc gag aag agc ttc agc gag aag tcc aag ctc acc aac cac     2400
 Pro Glu Cys Glu Lys Ser Phe Ser Glu Lys Ser Lys Leu Thr Asn His
             785                 790                 795

 tgc cgc gtg cac tcg cgc gca gcg gcc cgc caa gct cta tct ccc tcc     2448
 Cys Arg Val His Ser Arg Ala Ala Ala Arg Gln Ala Leu Ser Pro Ser
         800                 805                 810

 tag ctgcggcctt aattc                                                2466
 






      <210> 68
      <211> 5408
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (76)..(2364)

      <400> 68
 cggacgcgtg ggggcctgga gcccgctcta ggtgggtgtc ccctcggtgc ttcccagctg     60

 ccgtctgcac cagcc atg gac tgc tac acg gcg aac tgg aac cca ctc ggg     111
                  Met Asp Cys Tyr Thr Ala Asn Trp Asn Pro Leu Gly
                    1               5                  10

 gac tct gcc ttt tac cgg aaa tat gag ctg tac agc atg gac tgg gac      159
 Asp Ser Ala Phe Tyr Arg Lys Tyr Glu Leu Tyr Ser Met Asp Trp Asp
          15                  20                  25

 ctg aag gag gaa ctc agg gat tgc ctg gtg gct gct gca ccc tat ggg      207
 Leu Lys Glu Glu Leu Arg Asp Cys Leu Val Ala Ala Ala Pro Tyr Gly
      30                  35                  40

 ggc ccc att gca ctg ctg agg aac ccc tgg cgg aag gag aaa gct gct      255
 Gly Pro Ile Ala Leu Leu Arg Asn Pro Trp Arg Lys Glu Lys Ala Ala
  45                  50                  55                  60

 agt gtg agg cca gtg ctc gat ata tac tct gct tcc ggc atg cct ctg      303
 Ser Val Arg Pro Val Leu Asp Ile Tyr Ser Ala Ser Gly Met Pro Leu
                  65                  70                  75

 gcc agc ctg ctg tgg aag agt gga ccc gtg gtg tcc ctg ggc tgg tca      351
 Ala Ser Leu Leu Trp Lys Ser Gly Pro Val Val Ser Leu Gly Trp Ser
              80                  85                  90

 gct gag gag gag ctg ctc tgt gtg cag gaa gat ggt gct gta ctg gtt      399
 Ala Glu Glu Glu Leu Leu Cys Val Gln Glu Asp Gly Ala Val Leu Val
          95                 100                 105

 tat ggg ctt cat ggt gac ttc cgg aga cac ttc agc atg ggc aat gaa      447
 Tyr Gly Leu His Gly Asp Phe Arg Arg His Phe Ser Met Gly Asn Glu
     110                 115                 120

 gtg ctc cag aac cgg gtt ctg gat gcc cgg atc ttt cac act gag ttt      495
 Val Leu Gln Asn Arg Val Leu Asp Ala Arg Ile Phe His Thr Glu Phe
 125                 130                 135                 140

 ggt tcc gga gtg gcc atc ctc aca ggg gcc cac cgc ttc acc ctc agt      543
 Gly Ser Gly Val Ala Ile Leu Thr Gly Ala His Arg Phe Thr Leu Ser
                 145                 150                 155

 gcc aat gtg ggt gac ctc aaa ctc cgc cgg atg cca gag gtg cca ggt      591
 Ala Asn Val Gly Asp Leu Lys Leu Arg Arg Met Pro Glu Val Pro Gly
             160                 165                 170

 ctg caa agt gca ccc tcc tgc tgg act gtg ctg tgc cag gac cga gtg      639
 Leu Gln Ser Ala Pro Ser Cys Trp Thr Val Leu Cys Gln Asp Arg Val
         175                 180                 185

 gca cac att ctt ctg gct gtg ggg cct gac ctt tac ctc ttg gac cat      687
 Ala His Ile Leu Leu Ala Val Gly Pro Asp Leu Tyr Leu Leu Asp His
     190                 195                 200

 gca gcc tgc tcc gca gtg acg ccc cct ggc ctg gcc cca gga gta agc      735
 Ala Ala Cys Ser Ala Val Thr Pro Pro Gly Leu Ala Pro Gly Val Ser
 205                 210                 215                 220

 agc ttc cta cag atg gct gtc tcc ttc acc tac cga cac ctg gca ctc      783
 Ser Phe Leu Gln Met Ala Val Ser Phe Thr Tyr Arg His Leu Ala Leu
                 225                 230                 235

 ttc aca gac aca ggc tac atc tgg atg ggg aca gca tca ctc aag gag      831
 Phe Thr Asp Thr Gly Tyr Ile Trp Met Gly Thr Ala Ser Leu Lys Glu
             240                 245                 250

 aag cta tgt gag ttc aac tgc aac atc cgg gca cct cca aag cag atg      879
 Lys Leu Cys Glu Phe Asn Cys Asn Ile Arg Ala Pro Pro Lys Gln Met
         255                 260                 265

 gtc tgg tgc agc cgt cct cgt agc aag gag agg gcc gtg gtg gtg gcc      927
 Val Trp Cys Ser Arg Pro Arg Ser Lys Glu Arg Ala Val Val Val Ala
     270                 275                 280

 tgg gaa agg cgg ctg atg gtg gtg ggc gat gca ccc gag agc atc cag      975
 Trp Glu Arg Arg Leu Met Val Val Gly Asp Ala Pro Glu Ser Ile Gln
 285                 290                 295                 300

 ttt gtg ctg gat gag gac tcc tac ctg gtg cct gag ctc gat ggg gtc     1023
 Phe Val Leu Asp Glu Asp Ser Tyr Leu Val Pro Glu Leu Asp Gly Val
                 305                 310                 315

 cgc atc ttc tcc cgc agc acc cac gag ttc ctg cat gag gtt cca gcg     1071
 Arg Ile Phe Ser Arg Ser Thr His Glu Phe Leu His Glu Val Pro Ala
             320                 325                 330

 gcc agc gag gaa atc ttc aaa att gcc tca atg gcc ccc ggg gcg ctg     1119
 Ala Ser Glu Glu Ile Phe Lys Ile Ala Ser Met Ala Pro Gly Ala Leu
         335                 340                 345

 ctc ctg gag gct cag aag gag tat gag aaa gag agc cag aag gcg gac     1167
 Leu Leu Glu Ala Gln Lys Glu Tyr Glu Lys Glu Ser Gln Lys Ala Asp
     350                 355                 360

 gag tac ctg cgg gag atc cag gag ctg ggc cag ctg acc cag gcc gtg     1215
 Glu Tyr Leu Arg Glu Ile Gln Glu Leu Gly Gln Leu Thr Gln Ala Val
 365                 370                 375                 380

 cag cag tgc att gag gct gca gga cat gag cac cag cca gac atg cag     1263
 Gln Gln Cys Ile Glu Ala Ala Gly His Glu His Gln Pro Asp Met Gln
                 385                 390                 395

 aag agt ctg ctc agg gcc gcc tcc ttc gga aag tgt ttc ctg gac aga     1311
 Lys Ser Leu Leu Arg Ala Ala Ser Phe Gly Lys Cys Phe Leu Asp Arg
             400                 405                 410

 ttt cca ccc gac agc ttc gtg cac atg tgt cag gac ctg cgt gtg ctc     1359
 Phe Pro Pro Asp Ser Phe Val His Met Cys Gln Asp Leu Arg Val Leu
         415                 420                 425

 aat gct gtt cgg gac tat cac atc ggg atc ccg ctc acc tat agc caa     1407
 Asn Ala Val Arg Asp Tyr His Ile Gly Ile Pro Leu Thr Tyr Ser Gln
     430                 435                 440

 tat aag cag ctc acc atc cag gtg ctg ctg gac agg ctc gtg ttg cgg     1455
 Tyr Lys Gln Leu Thr Ile Gln Val Leu Leu Asp Arg Leu Val Leu Arg
 445                 450                 455                 460

 aga ctt tac ccc ctg gcc atc cag ata tgc gag tac ttg cgc ctt cct     1503
 Arg Leu Tyr Pro Leu Ala Ile Gln Ile Cys Glu Tyr Leu Arg Leu Pro
                 465                 470                 475

 gaa gta cag ggc gtc agc agg atc ctg gcc cac tgg gcc tgc tac aag     1551
 Glu Val Gln Gly Val Ser Arg Ile Leu Ala His Trp Ala Cys Tyr Lys
             480                 485                 490

 gtg caa cag aag gat gtc tca gat gag gat gtg gct cga gcc att aac     1599
 Val Gln Gln Lys Asp Val Ser Asp Glu Asp Val Ala Arg Ala Ile Asn
         495                 500                 505

 cag aag ctg ggg gac acg cct ggt gtc tct tac tcc gac att gct gca     1647
 Gln Lys Leu Gly Asp Thr Pro Gly Val Ser Tyr Ser Asp Ile Ala Ala
     510                 515                 520

 cga gcc tat ggt tgt ggc cgc acg gag ctg gcc atc aag ctg ctg gag     1695
 Arg Ala Tyr Gly Cys Gly Arg Thr Glu Leu Ala Ile Lys Leu Leu Glu
 525                 530                 535                 540

 tat gag cca cgc tca ggg gag cag ggg gac act cct gat gtg gct tac     1743
 Tyr Glu Pro Arg Ser Gly Glu Gln Gly Asp Thr Pro Asp Val Ala Tyr
                 545                 550                 555

 tcc gac att gct gca cga gcc tat ggt tgt ggg cgc acg gag ctg gcc     1791
 Ser Asp Ile Ala Ala Arg Ala Tyr Gly Cys Gly Arg Thr Glu Leu Ala
             560                 565                 570

 atc aag ctg ctg gag tat gag cca cgc tca ggg gag cag gta ccc ctt     1839
 Ile Lys Leu Leu Glu Tyr Glu Pro Arg Ser Gly Glu Gln Val Pro Leu
         575                 580                 585

 ctc cta aag atg aag agg agc aaa ctg gca cta agc aag gcc atc gag     1887
 Leu Leu Lys Met Lys Arg Ser Lys Leu Ala Leu Ser Lys Ala Ile Glu
     590                 595                 600

 agc ggg gac act gac ctg gtg ttc acg gtg ttg ctg cac ctg aag aac     1935
 Ser Gly Asp Thr Asp Leu Val Phe Thr Val Leu Leu His Leu Lys Asn
 605                 610                 615                 620

 gag ctg aac cga gga gat ttt ttc atg acc ctt cgg aat cag ccc atg     1983
 Glu Leu Asn Arg Gly Asp Phe Phe Met Thr Leu Arg Asn Gln Pro Met
                 625                 630                 635

 gcc ctc agt ttg tac cga cag ttc tgt aag cat cag gag cta gag acg     2031
 Ala Leu Ser Leu Tyr Arg Gln Phe Cys Lys His Gln Glu Leu Glu Thr
             640                 645                 650

 ctg aag gac ctt tac aat cag gat gac aat cac cag gaa ttg ggc agc     2079
 Leu Lys Asp Leu Tyr Asn Gln Asp Asp Asn His Gln Glu Leu Gly Ser
         655                 660                 665

 ttc cac atc cga gcc agc tat gct gca gaa gag cgt att gag ggg cga     2127
 Phe His Ile Arg Ala Ser Tyr Ala Ala Glu Glu Arg Ile Glu Gly Arg
     670                 675                 680

 gta gca gct ctg cag aca gcc gcc gat gcc ttc tac aag gcc aag aat     2175
 Val Ala Ala Leu Gln Thr Ala Ala Asp Ala Phe Tyr Lys Ala Lys Asn
 685                 690                 695                 700

 gag ttt gca gcc aag gct aca gag gat caa atg cgg ctc cta cgg ctg     2223
 Glu Phe Ala Ala Lys Ala Thr Glu Asp Gln Met Arg Leu Leu Arg Leu
                 705                 710                 715

 cag cgg cgc cta gaa gac gag ctg ggg ggc cag ttc cta gac ctg tct     2271
 Gln Arg Arg Leu Glu Asp Glu Leu Gly Gly Gln Phe Leu Asp Leu Ser
             720                 725                 730

 cta cat gac aca gtt acc acc ctc att ctt ggc ggt cac aac aag cgt     2319
 Leu His Asp Thr Val Thr Thr Leu Ile Leu Gly Gly His Asn Lys Arg
         735                 740                 745

 gca gag cag ctg gca cgt gac ttc cgc atc cct gac aag agg tga cac     2367
 Ala Glu Gln Leu Ala Arg Asp Phe Arg Ile Pro Asp Lys Arg 
     750                 755                 760

 aactaaaaaa aaacaaaggt atttatggaa ttccactgag tggtaatgga tgatgcagtt   2427

 caaataacta aggacacatg ttcaaagagc ataattaact ttttaaaaga agctaacaag   2487

 catggattcc tggttcattc ttgttctgct cggcagtggt ctgatatgtg tcagtgccaa   2547

 caatgctacc acagttgcac cttctgtagg aattacaaga ttaattaact catcaacggc   2607

 agaaccagtt aaagaagagg ccaaaacttc aaatccaact tcttcactaa cttctctttc   2667

 tgtggcacca acattcagcc caaatataac tctgggaccc acctatttaa ccactgtcaa   2727

 ttcttcagac tctgacaatg ggaccacaag aacagcaagc accaattcta taggcattac   2787

 aatttcacca aatggaacgt ggcttccaga taaccagttc acggatgcca gaacagaacc   2847

 ctgggagggg aattccagca ccgcagcaac cactccagaa actttccctc cttcaggtaa   2907

 ttctgactcg aaggacagaa gagatgagac accaattatt gcggtgatgg tggccctgtc   2967

 ctctctgcta gtgatcgtgt ttattatcat agttttgtac atgttaaggt ttaagaaata   3027

 caagcaagct gggagccatt ccaattcttt ccgcttatcc aacggccgca ctgaggatgt   3087

 ggagccccag agtgtgccac ttctggccag atccccaagc accaacagga aatacccacc   3147

 cctgcccgtg gacaagctgg aagaggaaat taaccggaga atggcagacg acaataagct   3207

 cttcagggag gaattcaacg ctctccctgc atgtcctatc caggccacct gtgaggctgc   3267

 ttccaaggag gaaaacaagg aaaaaaatcg atatgtaaac atcttgcctt atgaccactc   3327

 tagagtccac ctgacaccgg ttgaaggggt tccagattct gattacatca atgcttcatt   3387

 catcaacggt taccaagaaa agaacaaatt cattgctgca caaggaccaa aagaagaaac   3447

 ggtgaatgat ttctggcgga tgatctggga acaaaacaca gccaccatcg tcatggttac   3507

 caacctgaag gagagaaagg agtgcaagtg cgcccagtac tggccagacc aaggctgctg   3567

 gacctatggg aatattcggg tgtctgtaga ggatgtgact gtcctggtgg actacacagt   3627

 acggaagttc tgcatccagc aggtgggcga catgaccaac agaaagccac agcgcctcat   3687

 cactcagttc cactttacca gctggccaga ctttggggtg ccttttaccc cgatcggcat   3747

 gctcaagttc ctcaagaagg tgaaggcctg taaccctcag tatgcagggg ccatcgtggt   3807

 ccactgcagt gcaggtgtag ggcgtacagg tacctttgtc gtcattgatg ccatgctgga   3867

 catgatgcat acagaacgga aggtggacgt gtatggcttt gtgagccgga tccgggcaca   3927

 gcgctgccag atggtgcaaa ccgatatgca gtatgtcttc atataccaag cccttctgga   3987

 gcattatctc tatggagata cagaactgga agtgacctct ctagaaaccc acctgcagaa   4047

 aatttacaac aaaatcccag ggaccagcaa caatggatta gaggaggagt ttaagaagtt   4107

 aacatcaatc aaaatccaga atgacaagat gcggactgga aaccttccag ccaacatgaa   4167

 gaagaaccgt gttttacaga tcattccata tgaattcaac agagtgatca ttccagttaa   4227

 gcggggcgaa gagaatacag actatgtgaa cgcatccttt attgatggct accggcagaa   4287

 ggactcctat atcgccagcc agggccctct tctccacaca attgaggact tctggcgaat   4347

 gatctgggag tggaaatcct gctctatcgt gatgctaaca gaactggagg agagaggcca   4407

 ggagaagtgt gcccagtact ggccatctga tggactggtg tcctatggag atattacagt   4467

 ggaactgaag aaggaggagg aatgtgagag ctacaccgtc cgagacctcc tggtcaccaa   4527

 caccagggag aataagagcc ggcagatccg gcagttccac ttccatggct ggcctgaagt   4587

 gggcatcccc agtgacggaa agggcatgat cagcatcatc gccgccgtgc agaagcagca   4647

 gcagcagtca gggaaccacc ccatcaccgt gcactgcagc gccggggcag gaaggacggg   4707

 gaccttctgt gccctgagca ccgtcctgga gcgtgtgaaa gcagagggga ttttggatgt   4767

 cttccagact gtcaagagcc tgcggctaca gaggccacac atggtccaga cactggaaca   4827

 gtatgagttc tgctacaagg tggtgcagga gtatattgat gcattctcag attatgccaa   4887

 cttcaagtaa gcggcaacaa gggtccgtgg accaggagga ttgcctttaa tattttgtaa   4947

 tattctgttt tgttaatata ccccaaattg tgtatatatc ttataactgt tttagaaatt   5007

 ggtacatagg cttctattac ctattaggtg gaaattttat atgtaaatgt gttagcactg   5067

 atagtccttt ttccaatgtt ttattgggga attaaatagt gtgatgtttg gattgatatc   5127

 gtgaaatcct cagccgagaa attgggctgg attgcgcttt ggttaataca tctttcccta   5187

 aagaagataa acacaaaatc cattccaggt agctcggcac caactaagaa aaaaagcaca   5247

 aagttctcag agctctcgag gaaagtggtt gtccccgtac caccatgcac tgtaaatatc   5307

 cctcccctct ctccctggtc ccctccccca tccccaccac tgatatcatg gggagtaata   5367

 ggaccagagc ggtatctctg gcaccacact agcccgaatt c                       5408




      <210> 69
      <211> 2182
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (366)..(1628)

      <400> 69
 aaggatctta attaaattaa tccccccccc cccgctcggc tagcagcctg ggcacacgga     60

 cagacggact gacggactct cgagcggaca gcgcagctag cggggcgcgg gcgctgggcg    120

 tcgacggcca gccccagcct tccccgcccc gtcgcgcccc gccccgtccc gtcggggccg    180

 atggctcctc ccgaggcccg cagcccgggc ggcgcagggt agagcgccgc ggcccggcca    240

 cgcagcccgg ggactcccgg gccctcccgg agccccgcgg ggtccccgcc gtgcatccgg    300

 cgggctcagg gagcgagtgg gagcgccctc cccccgctgc cccctccccc gagcatcgag    360

 acaag    atg ctg ccc ggg ctc agg cgc ctg ctg caa gct ccc gcc tcg     407
          Met Leu Pro Gly Leu Arg Arg Leu Leu Gln Ala Pro Ala Ser
            1               5                  10

 gcc tgc ctc ctg ctg atg ctc ctg gcc ctg ccc ctg gcg gcc ccc agc      455
 Ala Cys Leu Leu Leu Met Leu Leu Ala Leu Pro Leu Ala Ala Pro Ser
  15                  20                  25                  30

 tgc ccc atg ctc tgc acc tgc tac tca tcc ccg ccc acc gtg agc tgc      503
 Cys Pro Met Leu Cys Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys
                  35                  40                  45

 cag gcc aac aac ttc tcc tct gtg ccg ctg tcc ctg cca ccc agc act      551
 Gln Ala Asn Asn Phe Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr
              50                  55                  60

 cag cga ctc ttc ctg cag aac aac ctc atc cgc acg ctg cgg cca ggc      599
 Gln Arg Leu Phe Leu Gln Asn Asn Leu Ile Arg Thr Leu Arg Pro Gly
          65                  70                  75

 acc ttt ggg tcc aac ctg ctc acc ctg tgg ctc ttc tcc aac aac ctc      647
 Thr Phe Gly Ser Asn Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu
      80                  85                  90

 tcc acc atc tac ccg ggc act ttc cgc cac ttg caa gcc ctg gag gag      695
 Ser Thr Ile Tyr Pro Gly Thr Phe Arg His Leu Gln Ala Leu Glu Glu
  95                 100                 105                 110

 ctg gac ctc ggt gac aac cgg cac ctg cgc tcg ctg gag ccc gac acc      743
 Leu Asp Leu Gly Asp Asn Arg His Leu Arg Ser Leu Glu Pro Asp Thr
                 115                 120                 125

 ttc cag ggc ctg gag cgg ctg cag tcg ctg cat ttg tac cgc tgc cag      791
 Phe Gln Gly Leu Glu Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln
             130                 135                 140

 ctc agc agc ctg ccc ggc aac atc ttc cga ggc ctg gtc agc ctg cag      839
 Leu Ser Ser Leu Pro Gly Asn Ile Phe Arg Gly Leu Val Ser Leu Gln
         145                 150                 155

 tac ctc tac ctc cag gag aac agc ctg ctc cac cta cag gat gac ttg      887
 Tyr Leu Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln Asp Asp Leu
     160                 165                 170

 ttc gcg gac ctg gcc aac ctg agc cac ctc ttc ctc cac ggg aac cgc      935
 Phe Ala Asp Leu Ala Asn Leu Ser His Leu Phe Leu His Gly Asn Arg
 175                 180                 185                 190

 ctg cgg ctg ctc aca gag cac gtg ttt cgc ggc ctg ggc agc ctg gac      983
 Leu Arg Leu Leu Thr Glu His Val Phe Arg Gly Leu Gly Ser Leu Asp
                 195                 200                 205

 cgg ctg ctg ctg cac ggg aac cgg ctg cag ggc gtg cac cgc gcg gcc     1031
 Arg Leu Leu Leu His Gly Asn Arg Leu Gln Gly Val His Arg Ala Ala
             210                 215                 220

 ttc cgc ggc ctc agc cgc ctc acc atc ctc tac ctg ttc aac aac agc     1079
 Phe Arg Gly Leu Ser Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser
         225                 230                 235

 ctg gcc tcg ctg ccc ggc gag gcg ctc gcc gac ctg ccc tcg ctc gag     1127
 Leu Ala Ser Leu Pro Gly Glu Ala Leu Ala Asp Leu Pro Ser Leu Glu
     240                 245                 250

 ttc ctg cgg ctc aac gct aac ccc tgg gcg tgc gac tgc cgc gcg cgg     1175
 Phe Leu Arg Leu Asn Ala Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg
 255                 260                 265                 270

 ccg ctc tgg gcc tgg ttc cag cgc gcg cgc gtg tcc agc tcc gac gtg     1223
 Pro Leu Trp Ala Trp Phe Gln Arg Ala Arg Val Ser Ser Ser Asp Val
                 275                 280                 285

 acc tgc gcc acc ccc ccg gag cgc cag ggc cga gac ctg cgc gcg ctc     1271
 Thr Cys Ala Thr Pro Pro Glu Arg Gln Gly Arg Asp Leu Arg Ala Leu
             290                 295                 300

 cgc gag gcc gac ttc cag gcg tgt ccg ccc gcg gca ccc acg cgg ccg     1319
 Arg Glu Ala Asp Phe Gln Ala Cys Pro Pro Ala Ala Pro Thr Arg Pro
         305                 310                 315

 ggc agc cgc gcc cgc ggc aac agc tcc tcc aac cac ctg tac ggg gtg     1367
 Gly Ser Arg Ala Arg Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val
     320                 325                 330

 gcc gag gcc ggg gcg ccc cca gcc gat ccc tcc acc ctc tac cga gat     1415
 Ala Glu Ala Gly Ala Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp
 335                 340                 345                 350

 ctg cct gcc gaa gac tcg cgg ggg cgc cag ggc ggg gac gcg cct act     1463
 Leu Pro Ala Glu Asp Ser Arg Gly Arg Gln Gly Gly Asp Ala Pro Thr
                 355                 360                 365

 gag gac gac tac tgg ggg ggc tac ggg ggt gag gac cag cga ggg gag     1511
 Glu Asp Asp Tyr Trp Gly Gly Tyr Gly Gly Glu Asp Gln Arg Gly Glu
             370                 375                 380

 cag atg tgc ccc ggc gct gcc tgc cag gcg ccc ccg gac tcc cga ggc     1559
 Gln Met Cys Pro Gly Ala Ala Cys Gln Ala Pro Pro Asp Ser Arg Gly
         385                 390                 395

 cct gcg ctc tcg gcc ggg ctc ccc agc cct ctg ctt tgc ctc ctg ctc     1607
 Pro Ala Leu Ser Ala Gly Leu Pro Ser Pro Leu Leu Cys Leu Leu Leu
     400                 405                 410

 ctg gtg ccc cac cac ctc tga ct gcggtgctga gatcgaagag gccagtgtcc     1660
 Leu Val Pro His His Leu 
 415                 420

 gatccccgct tcccgtccac ccggggctgc ggctccggcc ccagtcgccc caccttccct   1720

 ggccttgctg cctccctttc ccctcccagc tcctctcctc cccggggagc aggccgctct   1780

 ccttgcctgc cccctgggct gtcctgactt gtggcagccc caagagggcg tgtgtggtgg   1840

 ctcagccctg ccctccccag ttctggccat taactcttcc ccatcccaag gctggggtgg   1900

 ggccccccag gcagccgctg acccgcactc ctaagggccc acagcggaca ccagaggggc   1960

 ttttgtctgc agagcgtctt ccaccagcag agcctttgga agctccccca gggagcccac   2020

 ccaggaccct ttgggggatg cctcagtcag ggccaggctg accctgaccc tgcttaccct   2080

 agtcccctca actcctgaca ctggaggaat acttttctcc taagtctacc ctggaacact   2140

 tttaggggca ctggagagaa ctttcctctc cactgtggac ct                      2182




      <210> 70
      <211> 4526
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4526)

      <400> 70
  atg tgg gct cag ctc ctt cta gga atg ttg gcc cta tca cca gcc att      48
  Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile
    1               5                  10                  15

 gca gaa gaa ctt cca aac tac ctg gtg aca tta cca gcc cgg cta aat       96
 Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn
              20                  25                  30

 ttc ccc tcc gtt cag aag gtt tgt ttg gac ctg agc cct ggg tac agt      144
 Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser
          35                  40                  45

 gat gtt aaa ttc acg gtt act ctg gag acc aag gac aag acc cag aag      192
 Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys
      50                  55                  60

 ttg cta gaa tac tct gga ctg aag aag agg cac tta cat tgt atc tcc      240
 Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser
  65                  70                  75                  80

 ttt ctt gta cca cct cct gct ggt ggc aca gaa gaa gtg gcc aca atc      288
 Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile
                  85                  90                  95

 cgg gtg tcg gga gtt gga aat aac atc agc ttt gag gag aag aaa aag      336
 Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys
             100                 105                 110

 gtt cta att cag agg cag ggg aac ggc acc ttt gta cag act gac aaa      384
 Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys
         115                 120                 125

 cct ctc tac acc cca ggg cag caa gtg tat ttc cgc att gtc acc atg      432
 Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met
     130                 135                 140

 gat agc aac ttc gtt cca gtg aat gac aag tac tcc atg gtg gaa cta      480
 Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu
 145                 150                 155                 160

 cag gat cca aat agc aac agg att gca cag tgg ctg gaa gtg gta cct      528
 Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro
                 165                 170                 175

 gag caa ggc att gta gac ctg tcc ttc caa ctg gca cca gag gca atg      576
 Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met
             180                 185                 190

 ctg ggc acc tac act gtg gca gtg gct gag ggc aag acc ttt ggt act      624
 Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr
         195                 200                 205

 ttc agt gtg gag gaa tat gtg ctg ccg aag ttt aag gtg gaa gtg gtg      672
 Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val
     210                 215                 220

 gaa ccc aag gag tta tca acg gtg cag gaa tct ttc tta gta aaa att      720
 Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile
 225                 230                 235                 240

 tgt tgt agg tac acc tat gga aag ccc atg cta ggg gca gtg cag gta      768
 Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val
                 245                 250                 255

 tct gtg tgt cag aag gca aat act tac tgg tat cga gag gtg gaa cgg      816
 Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg
             260                 265                 270

 gaa cag ctt cct gac aaa tgc agg aac ctc tct gga cag act gac aaa      864
 Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys
         275                 280                 285

 aca gga tgt ttc tca gca cct gtg gac atg gcc acc ttt gac ctc att      912
 Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile
     290                 295                 300

 gga tat gcg tac agc cat caa atc aat att gtg gct act gtt gtg gag      960
 Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu
 305                 310                 315                 320

 gaa ggg aca ggt gtg gag gcc aat gcc act cag aat atc tac att tct     1008
 Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser
                 325                 330                 335

 cca caa atg gga tca atg acc ttt gaa gac acc agc aat ttt tac cat     1056
 Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His
             340                 345                 350

 cca aat ttc ccc ttc agt ggg aag ata aga gtt agg ggc cat gat gac     1104
 Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp
         355                 360                 365

 tcc ttc ctc aag aac cat cta gtg ttt ctg gtg att tat ggc aca aat     1152
 Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn
     370                 375                 380

 gga acc ttc aac cag acc ctg gtt act gat aac aat ggc cta gct ccc     1200
 Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro
 385                 390                 395                 400

 ttt acc ttg gag aca tcc ggt tgg aat ggg aca gac gtt tct ctg gag     1248
 Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu
                 405                 410                 415

 gga aag ttt caa atg gaa gac tta gta tat aat ccg gaa caa gtg cca     1296
 Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro
             420                 425                 430

 cgt tac tac caa aat gcc tac ctg cac ctg cga ccc ttc tac agc aca     1344
 Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr
         435                 440                 445

 acc cgc agc ttc ctt ggc atc cac cgg cta aac ggc ccc ttg aaa tgt     1392
 Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys
     450                 455                 460

 ggc cag ccc cag gaa gtg ctg gtg gat tat tac atc gac ccg gcc gat     1440
 Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp
 465                 470                 475                 480

 gca agc cct gac caa gag atc agc ttc tcc tac tat tta ata ggg aaa     1488
 Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys
                 485                 490                 495

 gga agt ttg gtg atg gag ggg cag aaa cac ctg aac tct aag aag aaa     1536
 Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys
             500                 505                 510

 gga ctg aaa gcc tcc ttc tct ctc tca ctg acc ttc act tcg aga ctg     1584
 Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu
         515                 520                 525

 gcc cct gat cct tcc ctg gtg atc tat gcc att ttt ccc agt gga ggt     1632
 Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly
     530                 535                 540

 gtt gta gct gac aaa att cag ttc tca gtc ggg atg tgc ttt gac aat     1680
 Val Val Ala Asp Lys Ile Gln Phe Ser Val Gly Met Cys Phe Asp Asn
 545                 550                 555                 560

 cag gtt tcc ctt ggc ttc tcc ccc tcc cag cag ctt cca gga gca gaa     1728
 Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu
                 565                 570                 575

 gtg gag ctg cag ctg cag gca gct ccc gga tcc ctg tgt gcg ctc cgg     1776
 Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg
             580                 585                 590

 gcg gtg gat gag agt gtc tta ctg ctt agg cca gac aga gag ctg agc     1824
 Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser
         595                 600                 605

 aac cgc tct gtc tat ggg atg ttt cca ttc tgg tat ggt cac tac ccc     1872
 Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro
     610                 615                 620

 tat caa gtg gct gag tat gat cag tgt cca gtg tct ggc cca tgg gac     1920
 Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp
 625                 630                 635                 640

 ttt cct cag ccc ctc att gac cca atg ccc caa ggg cat tcg agc cag     1968
 Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln
                 645                 650                 655

 cgt tcc att atc tgg agg ccc tcg ttc tct gaa ggc acg gac ctt ttc     2016
 Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe
             660                 665                 670

 agc ttt ttc cgg gac gtg ggc ctg aaa ata ctg tcc aat gcc aaa atc     2064
 Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile
         675                 680                 685

 aag aag cca gta gat tgc agt cac aga tct cca gaa tac agc act gct     2112
 Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala
     690                 695                 700

 atg ggt ggc ggt ggt cat cca gag gct ttt gag tca tca act cct tta     2160
 Met Gly Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro Leu
 705                 710                 715                 720

 cat caa gca gag gat tct cag gtc cgc cag tac ttc cca gag acc tgg     2208
 His Gln Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr Trp
                 725                 730                 735

 ctc tgg gat ctg ttt cct att ggt aac tcg ggg aag gag gcg gtc cac     2256
 Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val His
             740                 745                 750

 gtc aca gtt cct gac gcc atc acc gag tgg aag gcg atg agt ttc tgc     2304
 Val Thr Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe Cys
         755                 760                 765

 act tcc cag tca aga ggc ttc ggg ctt tca ccc act gtt gga cta act     2352
 Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu Thr
     770                 775                 780

 gct ttc aag ccg ttc ttt gtt gac ctg act ctc cct tac tca gta gtc     2400
 Ala Phe Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val Val
 785                 790                 795                 800

 cgt ggg gaa tcc ttt cgt ctt act gcc acc atc ttc aat tac cta aag     2448
 Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu Lys
                 805                 810                 815

 gat tgc atc agg gtt cag act gac ctg gct aaa tcg cat gag tac cag     2496
 Asp Cys Ile Arg Val Gln Thr Asp Leu Ala Lys Ser His Glu Tyr Gln
             820                 825                 830

 cta gaa tca tgg gca gat tct cag acc tcc agt tgt ctc tgt gct gat     2544
 Leu Glu Ser Trp Ala Asp Ser Gln Thr Ser Ser Cys Leu Cys Ala Asp
         835                 840                 845

 gac gca aaa acc cac cac tgg aac atc aca gct gtc aaa ttg ggt cac     2592
 Asp Ala Lys Thr His His Trp Asn Ile Thr Ala Val Lys Leu Gly His
     850                 855                 860

 att aac ttt act att agt aca aag att ctg gac agc aat gaa cca tgt     2640
 Ile Asn Phe Thr Ile Ser Thr Lys Ile Leu Asp Ser Asn Glu Pro Cys
 865                 870                 875                 880

 ggg ggc cag aag ggg ttt gtt ccc caa aag ggc cga agt gac acg ctc     2688
 Gly Gly Gln Lys Gly Phe Val Pro Gln Lys Gly Arg Ser Asp Thr Leu
                 885                 890                 895

 atc aag cca gtt ctc gtc aaa cct gag gga gtc ctg gtg gag aag aca     2736
 Ile Lys Pro Val Leu Val Lys Pro Glu Gly Val Leu Val Glu Lys Thr
             900                 905                 910

 cac agc tca ttg ctg tgc cca aaa gga aag gtg gca tct gaa tct gtc     2784
 His Ser Ser Leu Leu Cys Pro Lys Gly Lys Val Ala Ser Glu Ser Val
         915                 920                 925

 tcc ctg gag ctc cca gtg gac att gtt cct gac tcg acc aag gct tat     2832
 Ser Leu Glu Leu Pro Val Asp Ile Val Pro Asp Ser Thr Lys Ala Tyr
     930                 935                 940

 gtt acg gtt ctg ggt aag cag tta gag att ctt gac tca gaa agg aaa     2880
 Val Thr Val Leu Gly Lys Gln Leu Glu Ile Leu Asp Ser Glu Arg Lys
 945                 950                 955                 960

 agg cga atg gag gct gca aag gtg tgg aga gac att atg ggc aca gcc     2928
 Arg Arg Met Glu Ala Ala Lys Val Trp Arg Asp Ile Met Gly Thr Ala
                 965                 970                 975

 ctg cag aac ctg gat ggt ctg gtg cag atg ccc agt ggc tgt ggc gag     2976
 Leu Gln Asn Leu Asp Gly Leu Val Gln Met Pro Ser Gly Cys Gly Glu
             980                 985                 990

 cag aac atg gtc ttg ttt gct ccc atc atc tat gtc ttg cag tac ctg     3024
 Gln Asn Met Val Leu Phe Ala Pro Ile Ile Tyr Val Leu Gln Tyr Leu
         995                1000                1005

 gag aag gca ggg ctg ctg acg gag gag atc agg tct cgg gca gtg ggt     3072
 Glu Lys Ala Gly Leu Leu Thr Glu Glu Ile Arg Ser Arg Ala Val Gly
    1010                1015                1020

 ttc ctg gaa ata ggg tac cag aag gag ctg atg tac aaa cac agc aat     3120
 Phe Leu Glu Ile Gly Tyr Gln Lys Glu Leu Met Tyr Lys His Ser Asn
1025                1030                1035                1040

 ggc tca tac agt gcc ttt ggg gag cga gat gga aat gga aac aca tgg     3168
 Gly Ser Tyr Ser Ala Phe Gly Glu Arg Asp Gly Asn Gly Asn Thr Trp
                1045                1050                1055

 ctg aca gcg ttt gtc aca aaa tgc ttt ggc caa gct cag aaa ttc atc     3216
 Leu Thr Ala Phe Val Thr Lys Cys Phe Gly Gln Ala Gln Lys Phe Ile
            1060                1065                1070

 ttc att gat ccc aag aac atc cag gat gct ctc aag tgg atg gca gga     3264
 Phe Ile Asp Pro Lys Asn Ile Gln Asp Ala Leu Lys Trp Met Ala Gly
        1075                1080                1085

 aac cag ctc ccc agt ggc tgc tat gcc aac gtg gga aat ctc ctt cac     3312
 Asn Gln Leu Pro Ser Gly Cys Tyr Ala Asn Val Gly Asn Leu Leu His
    1090                1095                1100

 aca gct atg aag ggt ggt gtt gat gat gag gtc tcc ttg act gcg tat     3360
 Thr Ala Met Lys Gly Gly Val Asp Asp Glu Val Ser Leu Thr Ala Tyr
1105                1110                1115                1120

 gtc aca gct gca ttg ctg gag atg gga aag gat gta gat gac cca atg     3408
 Val Thr Ala Ala Leu Leu Glu Met Gly Lys Asp Val Asp Asp Pro Met
                1125                1130                1135

 gtg agt cag ggt cta cgg tgt ctc aag aat tcg gcc acc tcc acg acc     3456
 Val Ser Gln Gly Leu Arg Cys Leu Lys Asn Ser Ala Thr Ser Thr Thr
            1140                1145                1150

 aac ctc tac aca cag gcc ctg ttg gct tac att ttc tcc ctg gct ggg     3504
 Asn Leu Tyr Thr Gln Ala Leu Leu Ala Tyr Ile Phe Ser Leu Ala Gly
        1155                1160                1165

 gaa atg gac atc aga aac att ctc ctt aaa cag tta gat caa cag gct     3552
 Glu Met Asp Ile Arg Asn Ile Leu Leu Lys Gln Leu Asp Gln Gln Ala
    1170                1175                1180

 atc atc tca gga gaa tcc att tac tgg agc cag aaa cct act cca tca     3600
 Ile Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser
1185                1190                1195                1200

 tcg aac gcc agc cct tgg tct gag cct gcg gct gta gat gtg gaa ctc     3648
 Ser Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu
                1205                1210                1215

 aca gca tat gca ttg ttg gcc cag ctt acc aag ccc agc ctg act caa     3696
 Thr Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln
            1220                1225                1230

 aag gag ata gcg aag gcc act agc ata gtg gct tgg ttg gcc aag caa     3744
 Lys Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln
        1235                1240                1245

 cac aat gca tat ggg ggc ttc tct tct act cag gat act gta gtt gct     3792
 His Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala
    1250                1255                1260

 ctc caa gct ctt gcc aaa tat gcc act acc gcc tac atg cca tct gag     3840
 Leu Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Met Pro Ser Glu
1265                1270                1275                1280

 gag atc aac ctg gtt gta aaa tcc act gag aat ttc cag cgc aca ttc     3888
 Glu Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe
                1285                1290                1295

 aac ata cag tca gtt aac aga ttg gta ttt cag cag gat acc ctg ccc     3936
 Asn Ile Gln Ser Val Asn Arg Leu Val Phe Gln Gln Asp Thr Leu Pro
            1300                1305                1310

 aat gtc cct gga atg tac acg ttg gag gcc tca ggc cag ggc tgt gtc     3984
 Asn Val Pro Gly Met Tyr Thr Leu Glu Ala Ser Gly Gln Gly Cys Val
        1315                1320                1325

 tat gtg cag acg gtg ttg aga tac aat att ctc cct ccc aca aat atg     4032
 Tyr Val Gln Thr Val Leu Arg Tyr Asn Ile Leu Pro Pro Thr Asn Met
    1330                1335                1340

 aag acc ttt agt ctt agt gtg gaa ata gga aaa gct aga tgt gag caa     4080
 Lys Thr Phe Ser Leu Ser Val Glu Ile Gly Lys Ala Arg Cys Glu Gln
1345                1350                1355                1360

 ccg act tca cct cga tcc ttg act ctc act att cac acc agt tat gtg     4128
 Pro Thr Ser Pro Arg Ser Leu Thr Leu Thr Ile His Thr Ser Tyr Val
                1365                1370                1375

 ggg agc cgt agc tct tcc aat atg gct att gtg gaa gtg aag atg cta     4176
 Gly Ser Arg Ser Ser Ser Asn Met Ala Ile Val Glu Val Lys Met Leu
            1380                1385                1390

 tct ggg ttc agt ccc atg gag ggc acc aat cag tta ctt ctc cag caa     4224
 Ser Gly Phe Ser Pro Met Glu Gly Thr Asn Gln Leu Leu Leu Gln Gln
        1395                1400                1405

 ccc ctg gtg aag aag gtt gaa ttt gga act gac aca ctt aac att tac     4272
 Pro Leu Val Lys Lys Val Glu Phe Gly Thr Asp Thr Leu Asn Ile Tyr
    1410                1415                1420

 ttg gat gag ctc att aag aac act cag act tac acc ttc acc atc agc     4320
 Leu Asp Glu Leu Ile Lys Asn Thr Gln Thr Tyr Thr Phe Thr Ile Ser
1425                1430                1435                1440

 caa agt gtg ctg gtc acc aac ttg aaa cca gca acc atc aag gtc tat     4368
 Gln Ser Val Leu Val Thr Asn Leu Lys Pro Ala Thr Ile Lys Val Tyr
                1445                1450                1455

 gac tac tac cta cca ggt tct ttt aaa tta tct cag tac aca att gtg     4416
 Asp Tyr Tyr Leu Pro Gly Ser Phe Lys Leu Ser Gln Tyr Thr Ile Val
            1460                1465                1470

 tgg tcc atg aac aat gac agc ata gtg gac tct gtg gca cgg cac cca     4464
 Trp Ser Met Asn Asn Asp Ser Ile Val Asp Ser Val Ala Arg His Pro
        1475                1480                1485

 gaa cca ccc cct ttc aag aca gaa gca ttt att cct tca ctt cct ggg     4512
 Glu Pro Pro Pro Phe Lys Thr Glu Ala Phe Ile Pro Ser Leu Pro Gly
    1490                1495                1500

 agt gtt aac aac tg                                                  4526
 Ser Val Asn Asn 
1505





      <210> 71
      <211> 1626
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(1311)

      <400> 71
 ggcacgagga aaatcaagat aaaa   atg ttc aca att aag ctc ctt ctt ttt      51
                              Met Phe Thr Ile Lys Leu Leu Leu Phe
                                1               5

 att gtt cct cta gtt att tcc tcc aga att gat caa gac aat tca tca       99
 Ile Val Pro Leu Val Ile Ser Ser Arg Ile Asp Gln Asp Asn Ser Ser
  10                  15                  20                  25

 ttt gat tct cta tct cca gag cca aaa tca aga ttt gct atg tta gac      147
 Phe Asp Ser Leu Ser Pro Glu Pro Lys Ser Arg Phe Ala Met Leu Asp
                  30                  35                  40

 gat gta aaa att tta gcc aat ggc ctc ctt cag ttg gga cat ggt ctt      195
 Asp Val Lys Ile Leu Ala Asn Gly Leu Leu Gln Leu Gly His Gly Leu
              45                  50                  55

 aaa gac ttt gtc cat aag acg aag ggc caa att aat gac ata ttt caa      243
 Lys Asp Phe Val His Lys Thr Lys Gly Gln Ile Asn Asp Ile Phe Gln
          60                  65                  70

 aaa ctc aac ata ttt gat cag tct ttt tat gat cta tcg ctg caa acc      291
 Lys Leu Asn Ile Phe Asp Gln Ser Phe Tyr Asp Leu Ser Leu Gln Thr
      75                  80                  85

 agt gaa atc aaa gaa gaa gaa aag gaa ctg aga aga act aca tat aaa      339
 Ser Glu Ile Lys Glu Glu Glu Lys Glu Leu Arg Arg Thr Thr Tyr Lys
  90                  95                 100                 105

 cta caa gtc aaa aat gaa gag gta aag aat atg tca ctt gaa ctc aac      387
 Leu Gln Val Lys Asn Glu Glu Val Lys Asn Met Ser Leu Glu Leu Asn
                 110                 115                 120

 tca aaa ctt gaa agc ctc cta gaa gaa aaa att cta ctt caa caa aaa      435
 Ser Lys Leu Glu Ser Leu Leu Glu Glu Lys Ile Leu Leu Gln Gln Lys
             125                 130                 135

 gtg aaa tat tta gaa gag caa cta act aac tta att caa aat caa cct      483
 Val Lys Tyr Leu Glu Glu Gln Leu Thr Asn Leu Ile Gln Asn Gln Pro
         140                 145                 150

 gaa act cca gaa cac cca gaa gta act tca ctt aaa act ttt gta gaa      531
 Glu Thr Pro Glu His Pro Glu Val Thr Ser Leu Lys Thr Phe Val Glu
     155                 160                 165

 aaa caa gat aat agc atc aaa gac ctt ctc cag acc gtg gaa gac caa      579
 Lys Gln Asp Asn Ser Ile Lys Asp Leu Leu Gln Thr Val Glu Asp Gln
 170                 175                 180                 185

 tat aaa caa tta aac caa cag cat agt caa ata aaa gaa ata gaa aat      627
 Tyr Lys Gln Leu Asn Gln Gln His Ser Gln Ile Lys Glu Ile Glu Asn
                 190                 195                 200

 cag ctc aga agg act agt att caa gaa ccc aca gaa att tct cta tct      675
 Gln Leu Arg Arg Thr Ser Ile Gln Glu Pro Thr Glu Ile Ser Leu Ser
             205                 210                 215

 tcc aag cca aga gca cca aga act act ccc ttt ctt cag ttg aat gaa      723
 Ser Lys Pro Arg Ala Pro Arg Thr Thr Pro Phe Leu Gln Leu Asn Glu
         220                 225                 230

 ata aga aat gta aaa cat gat ggc att cct gct gaa tgt acc acc att      771
 Ile Arg Asn Val Lys His Asp Gly Ile Pro Ala Glu Cys Thr Thr Ile
     235                 240                 245

 tat aac aga ggt gaa cat aca agt ggc atg tat gcc atc aga ccc agc      819
 Tyr Asn Arg Gly Glu His Thr Ser Gly Met Tyr Ala Ile Arg Pro Ser
 250                 255                 260                 265

 aac tct caa gtt ttt cat gtc tac tgt gat gtt ata tca gga gaa ttt      867
 Asn Ser Gln Val Phe His Val Tyr Cys Asp Val Ile Ser Gly Glu Phe
                 270                 275                 280

 tgg ttg ggc cta gag aag ata tac tcc ata gtg aag caa tct aat tat      915
 Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile Val Lys Gln Ser Asn Tyr
             285                 290                 295

 gtt tta cga att gag ttg gaa gac tgg aaa gac aac aaa cat tat att      963
 Val Leu Arg Ile Glu Leu Glu Asp Trp Lys Asp Asn Lys His Tyr Ile
         300                 305                 310

 gaa tat tct ttt tac ttg gga aat cac gaa acc aac tat acg cta cat     1011
 Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu Thr Asn Tyr Thr Leu His
     315                 320                 325

 cta gtt gcg att act ggc aat gtc ccc aat gca atc ccg gaa aac aaa     1059
 Leu Val Ala Ile Thr Gly Asn Val Pro Asn Ala Ile Pro Glu Asn Lys
 330                 335                 340                 345

 gat ttg gtg ttt tct act tgg gat cac aaa gca aaa gga cac ttc aac     1107
 Asp Leu Val Phe Ser Thr Trp Asp His Lys Ala Lys Gly His Phe Asn
                 350                 355                 360

 tgt cca gag ggt tat tca gga ggc tgg tgg tgg cat gat gag tgt gga     1155
 Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp Trp His Asp Glu Cys Gly
             365                 370                 375

 gaa aac aac cta aat ggt aaa tat aac aaa cca aga gca aaa tct aag     1203
 Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys Pro Arg Ala Lys Ser Lys
         380                 385                 390

 cca gag agg aga aga gga tta tct tgg aag tct caa aat gga agg tta     1251
 Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys Ser Gln Asn Gly Arg Leu
     395                 400                 405

 tac tct ata aaa tca acc aaa atg ttg atc cat cca aca gat tca gaa     1299
 Tyr Ser Ile Lys Ser Thr Lys Met Leu Ile His Pro Thr Asp Ser Glu
 410                 415                 420                 425

 agc ttt gaa tga act gaggcaaatt taaaaggcaa taatttaaac attaacctca     1354
 Ser Phe Glu 


 ttccaagtta atgtggtcta ataatctggt attaaatcct taagagaaag cttgagaaat   1414

 agattttttt tatcttaaag tcactgtcta tttaagatta aacatacaat cacataacct   1474

 taaagaatac cgtttacatt tctcaatcaa aattcttata atactatttg ttttaaattt   1534

 tgtgatgtgg gaatcaattt tagatggtca caatctagat tataatcaat aggtgaactt   1594

 attaaataac ttttctaaat aaaaaaaaaa aa                                 1626




      <210> 72
      <211> 5357
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(3264)

      <400> 72
 tttcgtggaa gcagggactt gctgagagct gaacatctct gtttgatttg ctgtaacatg     60

 taaagcgaaa ctgggacatt ttactttaca gtctattaaa ggttatacaa aacttaaaag    120

 aagcagcaat tctattcgct tgttattgga cttgaaactc cctttgacct cggaaag       177                                                                 
 atg agg ttg cca tgg gaa ctg ctg gta ctg caa tca ttc att ttg tgc      225
 Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys
   1               5                  10                  15

 ctt gca gat gat tcc aca ctg cat ggc ccg att ttt att caa gaa cca      273
 Leu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro
              20                  25                  30

 agt cct gta atg ttc cct ttg gat tct gag gag aaa aaa gtg aag ctc      321
 Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu
          35                  40                  45

 aat tgt gaa gtt aaa gga aat cca aaa cct cat tat agg tgg aag tta      369
 Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Tyr Arg Trp Lys Leu
      50                  55                  60

 aat gga aca gat gtt gac act ggt atg gat ttc cgc tac agt gtt gtt      417
 Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val
  65                  70                  75                  80

 gaa ggg agc ttg ttg atc aat aac ccc aat aaa acc caa gat gct gga      465
 Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly
                  85                  90                  95

 acg tac cag tgc aca gcg aca aac tcg ttt gga aca att gtt agc aga      513
 Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg
             100                 105                 110

 gaa gca aag ctt cag ttt gct tat ctt gaa aat ttt aaa acc aaa atg      561
 Glu Ala Lys Leu Gln Phe Ala Tyr Leu Glu Asn Phe Lys Thr Lys Met
         115                 120                 125

 agg agt aca gtg tct gtg cgt gaa ggc cag gga gtt gtg ctg ctc tgc      609
 Arg Ser Thr Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Leu Cys
     130                 135                 140

 ggc ccc cca cca cac tct gga gaa ctg tca tat gct tgg atc ttc aat      657
 Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn
 145                 150                 155                 160

 gaa tac cca tcg ttt gtt gaa gaa gat agt cgg aga ttt gtc tcc cag      705
 Glu Tyr Pro Ser Phe Val Glu Glu Asp Ser Arg Arg Phe Val Ser Gln
                 165                 170                 175

 gag aca ggg cac ctc tac ata tct aag gtg gag ccg tct gat gtg gga      753
 Glu Thr Gly His Leu Tyr Ile Ser Lys Val Glu Pro Ser Asp Val Gly
             180                 185                 190

 aat tac aca tgt gtg gtg aca agt atg gtg aca aat gcc cga gtg ctg      801
 Asn Tyr Thr Cys Val Val Thr Ser Met Val Thr Asn Ala Arg Val Leu
         195                 200                 205

 ggc tct cca act cct ttg gtg cta cgt tct gat ggt gtg atg ggt gaa      849
 Gly Ser Pro Thr Pro Leu Val Leu Arg Ser Asp Gly Val Met Gly Glu
     210                 215                 220

 tat gaa cct aaa ata gaa gtt cag ttt cca gaa act ctt cca gca gct      897
 Tyr Glu Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Leu Pro Ala Ala
 225                 230                 235                 240

 aaa ggt tcg act gtg aaa ttg gaa tgt ttt gcc ctt gga aat ccc ata      945
 Lys Gly Ser Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Ile
                 245                 250                 255

 cct cag att aat tgg aga aga agt gat ggg ctg cca ttt tcc agc aaa      993
 Pro Gln Ile Asn Trp Arg Arg Ser Asp Gly Leu Pro Phe Ser Ser Lys
             260                 265                 270

 att aaa tta agg aag ttc agt ggt gtg ctt gaa atc ccc aac ttc caa     1041
 Ile Lys Leu Arg Lys Phe Ser Gly Val Leu Glu Ile Pro Asn Phe Gln
         275                 280                 285

 cag gaa gat gca ggt tcc tat gaa tgc att gct gag aat tca cga gga     1089
 Gln Glu Asp Ala Gly Ser Tyr Glu Cys Ile Ala Glu Asn Ser Arg Gly
     290                 295                 300

 aaa aat gtt gcc aga ggg cgt ctc act tac tat gca aag ccc cat tgg     1137
 Lys Asn Val Ala Arg Gly Arg Leu Thr Tyr Tyr Ala Lys Pro His Trp
 305                 310                 315                 320

 gtt caa ctc ata aag gat gtg gaa ata gcc gtg gag gac agt ctt tat     1185
 Val Gln Leu Ile Lys Asp Val Glu Ile Ala Val Glu Asp Ser Leu Tyr
                 325                 330                 335

 tgg gaa tgc agg gca agc ggc aag ccc aag cct tcc tac cga tgg ctg     1233
 Trp Glu Cys Arg Ala Ser Gly Lys Pro Lys Pro Ser Tyr Arg Trp Leu
             340                 345                 350

 aaa aat gga gca gcc ctg gtg cta gag gag aga aca cag ata gaa aat     1281
 Lys Asn Gly Ala Ala Leu Val Leu Glu Glu Arg Thr Gln Ile Glu Asn
         355                 360                 365

 ggt gcc ctt aca ata tca aac cta agt gtg act gat tct ggc atg ttc     1329
 Gly Ala Leu Thr Ile Ser Asn Leu Ser Val Thr Asp Ser Gly Met Phe
     370                 375                 380

 cag tgc ata gca gaa aac aaa cat ggc ctt gtt tat tcc agt gct gag     1377
 Gln Cys Ile Ala Glu Asn Lys His Gly Leu Val Tyr Ser Ser Ala Glu
 385                 390                 395                 400

 ctc aaa gtt gtt gct tct gct cca gat ttt tca aag aat cca atg aag     1425
 Leu Lys Val Val Ala Ser Ala Pro Asp Phe Ser Lys Asn Pro Met Lys
                 405                 410                 415

 aag ttg gtt cag gtg cag gtg ggc agc ctg gtc agc ttg gat tgt aaa     1473
 Lys Leu Val Gln Val Gln Val Gly Ser Leu Val Ser Leu Asp Cys Lys
             420                 425                 430

 ccc aga gcc tcc cca agg gca ctc tct tcc tgg aag aag ggg gat gtg     1521
 Pro Arg Ala Ser Pro Arg Ala Leu Ser Ser Trp Lys Lys Gly Asp Val
         435                 440                 445

 agc gtg cag gag cat gaa aga att tct ttg tta aac gat gga gga ctc     1569
 Ser Val Gln Glu His Glu Arg Ile Ser Leu Leu Asn Asp Gly Gly Leu
     450                 455                 460

 aaa ata gcc aat gtg act aaa gct gat gct gga act tac acc tgc atg     1617
 Lys Ile Ala Asn Val Thr Lys Ala Asp Ala Gly Thr Tyr Thr Cys Met
 465                 470                 475                 480

 gca gaa aac cag ttt ggg aaa gca aat ggc aca aca cat ttg gtt gtt     1665
 Ala Glu Asn Gln Phe Gly Lys Ala Asn Gly Thr Thr His Leu Val Val
                 485                 490                 495

 acg gaa cca aca aga ata act ttg gca cca tct aac atg gat gtt tct     1713
 Thr Glu Pro Thr Arg Ile Thr Leu Ala Pro Ser Asn Met Asp Val Ser
             500                 505                 510

 gtt ggt gaa agc gtc ata ttg ccc tgc cag gta caa cat gac ccg ctg     1761
 Val Gly Glu Ser Val Ile Leu Pro Cys Gln Val Gln His Asp Pro Leu
         515                 520                 525

 tta gac atc atc ttt acc tgg tat ttc aat ggg gcc ctt gca gat ttt     1809
 Leu Asp Ile Ile Phe Thr Trp Tyr Phe Asn Gly Ala Leu Ala Asp Phe
     530                 535                 540

 aag aaa gat gga tct cac ttt gag aaa gtt ggt ggg agt tca tct ggt     1857
 Lys Lys Asp Gly Ser His Phe Glu Lys Val Gly Gly Ser Ser Ser Gly
 545                 550                 555                 560

 gat tta atg atc aga aac att cag ctg aaa cac agt ggg aaa tat gtt     1905
 Asp Leu Met Ile Arg Asn Ile Gln Leu Lys His Ser Gly Lys Tyr Val
                 565                 570                 575

 tgt atg gtg caa acg ggg gtg gac agt gtt tca tct gct gct gac ctc     1953
 Cys Met Val Gln Thr Gly Val Asp Ser Val Ser Ser Ala Ala Asp Leu
             580                 585                 590

 ata gta aga ggt tca cct gga cca cca gaa aat gtg aag gta gat gaa     2001
 Ile Val Arg Gly Ser Pro Gly Pro Pro Glu Asn Val Lys Val Asp Glu
         595                 600                 605

 att aca gac aca aca gcc caa ctc tct tgg aaa gaa ggt aaa gac aac     2049
 Ile Thr Asp Thr Thr Ala Gln Leu Ser Trp Lys Glu Gly Lys Asp Asn
     610                 615                 620

 cat agc cca gtt ata tcc tat tct atc cag gct cgg aca cct ttc tcc     2097
 His Ser Pro Val Ile Ser Tyr Ser Ile Gln Ala Arg Thr Pro Phe Ser
 625                 630                 635                 640

 gtg ggt tgg caa acc gtc aca aca gtg cct gag gtc atc gat ggg aag     2145
 Val Gly Trp Gln Thr Val Thr Thr Val Pro Glu Val Ile Asp Gly Lys
                 645                 650                 655

 acg cac aca gcc act gta gtt gag tta aac cca tgg gtg gaa tat gaa     2193
 Thr His Thr Ala Thr Val Val Glu Leu Asn Pro Trp Val Glu Tyr Glu
             660                 665                 670

 ttt cgg gtt gta gcc agt aac aaa att gga ggt gga gaa cca agt tta     2241
 Phe Arg Val Val Ala Ser Asn Lys Ile Gly Gly Gly Glu Pro Ser Leu
         675                 680                 685

 ccc tca gaa aaa gta aga act gaa gag gca gtt cca gaa gtg cct cct     2289
 Pro Ser Glu Lys Val Arg Thr Glu Glu Ala Val Pro Glu Val Pro Pro
     690                 695                 700

 tct gaa gtc aat gga gga ggc gga agc cgg tct gaa ctt gtg ata acc     2337
 Ser Glu Val Asn Gly Gly Gly Gly Ser Arg Ser Glu Leu Val Ile Thr
 705                 710                 715                 720

 tgg gat cca gtc cct gaa gaa cta cag aat ggt gaa ggt ttt ggg tat     2385
 Trp Asp Pro Val Pro Glu Glu Leu Gln Asn Gly Glu Gly Phe Gly Tyr
                 725                 730                 735

 gtt gtt gct ttc cgc cct ctt ggg gtt acc acc tgg atc cag aca gtg     2433
 Val Val Ala Phe Arg Pro Leu Gly Val Thr Thr Trp Ile Gln Thr Val
             740                 745                 750

 gtg aca tcc cct gac acc cca aga tat gtc ttt agg aat gaa agc atc     2481
 Val Thr Ser Pro Asp Thr Pro Arg Tyr Val Phe Arg Asn Glu Ser Ile
         755                 760                 765

 gtg cca tat tca cca tat gaa gtt aaa gtg ggt gtt tat aat aac aaa     2529
 Val Pro Tyr Ser Pro Tyr Glu Val Lys Val Gly Val Tyr Asn Asn Lys
     770                 775                 780

 ggt gaa gga cca ttt agc cca gtg aca aca gtg ttc tct gca gaa gaa     2577
 Gly Glu Gly Pro Phe Ser Pro Val Thr Thr Val Phe Ser Ala Glu Glu
 785                 790                 795                 800

 gag cct aca gtg gcc cca tct caa gtc tct gca aat agc cta tct tcc     2625
 Glu Pro Thr Val Ala Pro Ser Gln Val Ser Ala Asn Ser Leu Ser Ser
                 805                 810                 815

 tca gaa att gag gtt tca tgg aac acc att cct tgg aag ttg agc aat     2673
 Ser Glu Ile Glu Val Ser Trp Asn Thr Ile Pro Trp Lys Leu Ser Asn
             820                 825                 830

 gga cat tta ctg ggc tat gag gtg cgg tac tgg aat ggg ggt gga aag     2721
 Gly His Leu Leu Gly Tyr Glu Val Arg Tyr Trp Asn Gly Gly Gly Lys
         835                 840                 845

 gag gaa tca tcc agt aag atg aaa gtg gca gga aat gag aca tca gcc     2769
 Glu Glu Ser Ser Ser Lys Met Lys Val Ala Gly Asn Glu Thr Ser Ala
     850                 855                 860

 aga cta cgg ggc ctg aag agc aac ctg gcc tat tac acg gct gtc cgg     2817
 Arg Leu Arg Gly Leu Lys Ser Asn Leu Ala Tyr Tyr Thr Ala Val Arg
 865                 870                 875                 880

 gct tac aac agt gcc ggc gct ggg cct ttt agc gcc aca gtt aat gta     2865
 Ala Tyr Asn Ser Ala Gly Ala Gly Pro Phe Ser Ala Thr Val Asn Val
                 885                 890                 895

 acc acc aag aaa acg cct ccc agt cag cca cca gga aat gtt gtt tgg     2913
 Thr Thr Lys Lys Thr Pro Pro Ser Gln Pro Pro Gly Asn Val Val Trp
             900                 905                 910

 aat gcc aca gac act aaa gtg tta ctt aat tgg gag caa gtt aaa gcc     2961
 Asn Ala Thr Asp Thr Lys Val Leu Leu Asn Trp Glu Gln Val Lys Ala
         915                 920                 925

 atg gag aat gag tca gaa gta aca gga tat aaa gtt ttc tat agg act     3009
 Met Glu Asn Glu Ser Glu Val Thr Gly Tyr Lys Val Phe Tyr Arg Thr
     930                 935                 940

 agc agt caa aat aac gta caa gta ctg aac aca aat aaa act tca gct     3057
 Ser Ser Gln Asn Asn Val Gln Val Leu Asn Thr Asn Lys Thr Ser Ala
 945                 950                 955                 960

 gaa ctt gtg ctg ccc att aaa gag gac tac att att gaa gtc aag gcc     3105
 Glu Leu Val Leu Pro Ile Lys Glu Asp Tyr Ile Ile Glu Val Lys Ala
                 965                 970                 975

 aca aca gat gga ggg gat ggg acc agt agt gaa cag atc agg att cca     3153
 Thr Thr Asp Gly Gly Asp Gly Thr Ser Ser Glu Gln Ile Arg Ile Pro
             980                 985                 990

 cga ata acc agt atg gat gca aga gga tcc act tca gcc atc tcg aat     3201
 Arg Ile Thr Ser Met Asp Ala Arg Gly Ser Thr Ser Ala Ile Ser Asn
         995                1000                1005

 gtc cac cct atg tca agt tat atg cct ata gta ctg ttc tta att gta     3249
 Val His Pro Met Ser Ser Tyr Met Pro Ile Val Leu Phe Leu Ile Val
    1010                1015                1020

 tat gtc ctg tgg tga tattaactcc tttttattat ttattggaaa gttatttggt     3304
 Tyr Val Leu Trp 
1025

 taccaaaaaa agtgctttca tgaaatgcag ggattatgca tgtttttttc aactcttatt   3364

 tttaactttc tacttcatta taggtaaata tgaatataat taaaaaaaca gtaaatcctt   3424

 ttaggggaat ctgaaatgcc ttaatattaa cttgataaac caaaggaatt tacatattac   3484

 atacttcaga cttttgatat aaatgttctt aaactatgag tttaagcact gcctatggat   3544

 aaagactcac acactctcac atgtacacac acacgcatga gaatttcttt ttacattgaa   3604

 aaactctttc atttaattca aatgctattt tcccattata atagcattat ttggaagact   3664

 taaccagtat caatttgaaa tgctgattta agtccccaag gatgaaaaat acattttaaa   3724

 aattattttg ttggagagga gtggcatgtg attcaaaaga gcattgttgg aaaatgctac   3784

 tgtggggctt agaagaatga tgtttggttt ggtatgctgc taactagttg taagacttta   3844

 caaatcactt tgccatctgt acctctcaat tattcctcta taaaatatgg agataataat   3904

 acctatctga tcagactttg ccccatgaat tagtttttaa aagataaaga ctgaagtatg   3964

 aaagtgcttt tgtcacccca aatgcaattg acccatgcaa aatattagca tgaatttatt   4024

 taatcacata aaagtcatga agaccagcca gattttcaag cttcattctg tttcattcag   4084

 ttatattcca aaattcaaat gatcacattt tattctttct caaaaaaaaa aagttttttt   4144

 aaattaaaaa aggaattgtt tccttcacag ctatgaataa gctttcaggt tttattaaaa   4204

 cctagaggaa aaaatcagga atgacctgaa tctcaaccca aatattaaac aaaatccaca   4264

 taatccctca tttcaatttc caattccatt aagggaccct ctctttttgg atggcagaga   4324

 tggtttttta atgaaatccc accatctatc tgagtgagtc tggcaggctt tttagttcct   4384

 gagttaaatt tgtaatagaa ccaaggcaat gctgctgact ttgatatgta tgactcagtc   4444

 tttcaatatg tggttttcaa aaaattgttg aagacgtgac ttcatagcaa tatatagaga   4504

 ataaattaaa atcagcagat tgagttttca acattgcaaa atcagttttt tacctctttc   4564

 ctaccaattt cacattttgc agaaacttgt tcatatttcc aacaatatca gaattagaaa   4624

 acagttcaga taacaagaaa gattaaaaat tagggaaatt ctgatatcac cataaagcac   4684

 tattttacat ttagagatta catttaagat aaagtcatca tacacaaaaa caataaatat   4744

 ttataacttt ctctataagg tccgcatata ctgtatatat tgaaacaatc tgaatgacta   4804

 gtagatttca tatgaccatt gttatttcca ctttctccaa tacttgtatt ttatgctaca   4864

 tgtaatgaag ttggaccttt ttattattta gtaattccta tatgttccta tacttttcat   4924

 tttcaagatg attgctctat tgtttcatgt tgtttctagc aatatatctc catgagatat   4984

 gcactttgtt tcatattgaa aagtataaaa tttatctttc aattcctgtg tgtgtatcct   5044

 atggttatct gtatgtatta ttttctattc taataaaatt tataacaagc aaaaaaaaaa   5104

 aaaaacacac acaaagtaga acacaagaaa agagggggcg ccgcaaaaag gatccgccag   5164

 gggagccaac aataacaata cccccaatgt cgtgcgtaac aacaggccac aaaagggggt   5224

 gcgtacaaag agaagcacac gcgcgcagtt atacagacgc gatgaagagc gaaacactga   5284

 cgaggagaat aggagagaca ccaacacggg cggaagacat gcggcagcgc gacgaaatta   5344

 acacacgaga aat                                                      5357




      <210> 73
      <211> 3605
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1076)..(3235)

      <400> 73
 gatatggagc ggctgctggg ctgtaaaacc aggtgtgtgg atcgctttac ccagaagctt     60

 ggaaagcgcc aatattaacc tgcttccagg tacatcacaa ggtcaagaga gtgtcttgca    120

 gccctcttgt ttccgtgtat ctacaccttc ttctcttggc cagaaggata tttacgtttt    180

 ggttcacagc atttgaagcc aaaagttcag cccttcgaac tggtttgcta tacaaaacaa    240

 aacaaaacaa ataaggtaat gaggattgct tattaaactg cttaacaaaa tccccgactc    300

 ttcctcagcc ctttctcggc tccctcctcc ccaccaaaat gtcaccagct cttgaattac    360

 gtggattcgg gttggaggag aacttgaagg aaacgtgatt aaagggctat gcgagaacgc    420

 tctctttgct gcccgcggtc cggtgggctt cgaagccaat cgtgagaagg accggttccc    480

 tccgtgctgc ttcctccccg tgcagtgctg ggtgtgcgtg tgcgagtgtg agtgcaagtg    540

 cgcgcgcgcc cgggtgcgag tgtgtgtgag tgtgagcgtg tgtctgtgtg tgcgtgcgcg    600

 gccgccctgc ctctgcccgc tccccgggcg cggagccgcg ggtttcatgg ggcgattgca    660

 gcgattcccc cacccagagc gacctgcggg cagcggcggc agtggcagga gccgcctttc    720

 cgattcccta cgatgcgggt gctgagctat ggcaaagggc agcgaagtga cgagcgagac    780

 ccgcgtacga ctgtgaaagc cacctggagc caccttgccg ggattgtacc tgcaggcaga    840

 aagtcttcct acgaccgtct tttcccttag aggcaccaga atccctgtaa ccattcatcc    900

 aggtgttgag aagatatgta gcagccgagc acccatcttt tgacaccgtc ctctgaaatc    960

 agctttggag atgctttcac tctgtccgtc ttctgcagca gccaggcaga gtgccgactc   1020

 cttcacagcc gtgaggaact cttcaggctc cagaagctct taaacctgat ctaca atg    1078
                                                              Met
                                                                1

 gaa aaa att ctt ttt tat ctg ttt ctc att ggc ata gca gtg aaa gct     1126
 Glu Lys Ile Leu Phe Tyr Leu Phe Leu Ile Gly Ile Ala Val Lys Ala
               5                  10                  15

 cag atc tgt cca aag cgt tgt gtc tgt cag att ttg tct cct aat ctt     1174
 Gln Ile Cys Pro Lys Arg Cys Val Cys Gln Ile Leu Ser Pro Asn Leu
          20                  25                  30

 gca acc ctt tgt gcc aag aaa ggg ctt tta ttt gtt cca cca aac att     1222
 Ala Thr Leu Cys Ala Lys Lys Gly Leu Leu Phe Val Pro Pro Asn Ile
      35                  40                  45

 gac aga aga act gtg gaa ctg cgg ttg gca gac aat ttt gtt aca aat     1270
 Asp Arg Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Val Thr Asn
  50                  55                  60                  65

 att aaa agg aaa gat ttt gcc aat atg acc agc ttg gtg gac ctg act     1318
 Ile Lys Arg Lys Asp Phe Ala Asn Met Thr Ser Leu Val Asp Leu Thr
                  70                  75                  80

 cta tcc agg aat aca ata agt ttt att aca cct cat gct ttc gct gac     1366
 Leu Ser Arg Asn Thr Ile Ser Phe Ile Thr Pro His Ala Phe Ala Asp
              85                  90                  95

 cta cga aat ttg agg gct ttg cat ttg aat agc aac aga ttg act aaa     1414
 Leu Arg Asn Leu Arg Ala Leu His Leu Asn Ser Asn Arg Leu Thr Lys
         100                 105                 110

 att aca aat gat atg ttc agt ggt ctt tcc aat ctt cat cat ttg ata     1462
 Ile Thr Asn Asp Met Phe Ser Gly Leu Ser Asn Leu His His Leu Ile
     115                 120                 125

 ctg aac aac aat cag ctg act tta att tcc tct aca gcg ttt gat gat     1510
 Leu Asn Asn Asn Gln Leu Thr Leu Ile Ser Ser Thr Ala Phe Asp Asp
 130                 135                 140                 145

 gtc ttc gcc ctt gag gag ctg gat ctg tcc tat aat aat cta gaa acc     1558
 Val Phe Ala Leu Glu Glu Leu Asp Leu Ser Tyr Asn Asn Leu Glu Thr
                 150                 155                 160

 att cct tgg gat gct gtt gag aag atg gtt agc ttg cat acc ctt agt     1606
 Ile Pro Trp Asp Ala Val Glu Lys Met Val Ser Leu His Thr Leu Ser
             165                 170                 175

 ttg gat cac aat atg att gat aac att cct aag ggg acc ttc tcc cat     1654
 Leu Asp His Asn Met Ile Asp Asn Ile Pro Lys Gly Thr Phe Ser His
         180                 185                 190

 ttg cac aag atg act cgg tta gat gtg aca tca aat aaa ttg cag aag     1702
 Leu His Lys Met Thr Arg Leu Asp Val Thr Ser Asn Lys Leu Gln Lys
     195                 200                 205

 cta cca cct gac cct ctc ttt cag cga gct cag gta cta gca acc tca     1750
 Leu Pro Pro Asp Pro Leu Phe Gln Arg Ala Gln Val Leu Ala Thr Ser
 210                 215                 220                 225

 gga atc ata agc cca tct act ttt gca tta agt ttt ggt gga aac ccc     1798
 Gly Ile Ile Ser Pro Ser Thr Phe Ala Leu Ser Phe Gly Gly Asn Pro
                 230                 235                 240

 ttg cat tgc aat tgt gaa ttg ttg tgg ttg agg cgt ctg tcc aga gaa     1846
 Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Ser Arg Glu
             245                 250                 255

 gat gac tta gag acc tgt gct tct cct cca ctt tta act ggc cgc tac     1894
 Asp Asp Leu Glu Thr Cys Ala Ser Pro Pro Leu Leu Thr Gly Arg Tyr
         260                 265                 270

 ttt tgg tca att cct gaa gaa gag ttt ttg tgt gag cct cct ctc att     1942
 Phe Trp Ser Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu Ile
     275                 280                 285

 act cgt cat aca cat gag atg aga gtc ctg gag gga caa agg gca aca     1990
 Thr Arg His Thr His Glu Met Arg Val Leu Glu Gly Gln Arg Ala Thr
 290                 295                 300                 305

 ctg agg tgc aaa gcc agg gga gac cct gag cct gca att cac tgg att     2038
 Leu Arg Cys Lys Ala Arg Gly Asp Pro Glu Pro Ala Ile His Trp Ile
                 310                 315                 320

 tct cct gaa ggg aag ctt att tca aat gca aca aga tct ctg gtg tat     2086
 Ser Pro Glu Gly Lys Leu Ile Ser Asn Ala Thr Arg Ser Leu Val Tyr
             325                 330                 335

 gat aac gga aca ctt gac att ctt atc aca act gta aag gat aca ggt     2134
 Asp Asn Gly Thr Leu Asp Ile Leu Ile Thr Thr Val Lys Asp Thr Gly
         340                 345                 350

 gct ttt acc tgc att gct tcc aat cct gct ggg gaa gca aca caa ata     2182
 Ala Phe Thr Cys Ile Ala Ser Asn Pro Ala Gly Glu Ala Thr Gln Ile
     355                 360                 365

 gtg gat ctt cat ata att aag ctc cct cac tta cta aat agt aca aac     2230
 Val Asp Leu His Ile Ile Lys Leu Pro His Leu Leu Asn Ser Thr Asn
 370                 375                 380                 385

 cat atc cat gag cct gat cct ggt tct tca gat atc tca act tct acc     2278
 His Ile His Glu Pro Asp Pro Gly Ser Ser Asp Ile Ser Thr Ser Thr
                 390                 395                 400

 aag tca ggt tct aat aca agc agt agt aat ggt gat act aaa ttg agt     2326
 Lys Ser Gly Ser Asn Thr Ser Ser Ser Asn Gly Asp Thr Lys Leu Ser
             405                 410                 415

 caa gat aaa att gtg gtg gca gaa gct aca tca tca acg gca cta ctt     2374
 Gln Asp Lys Ile Val Val Ala Glu Ala Thr Ser Ser Thr Ala Leu Leu
         420                 425                 430

 aaa ttt aat ttt caa aga aat atc cct gga ata cgt atg ttt caa atc     2422
 Lys Phe Asn Phe Gln Arg Asn Ile Pro Gly Ile Arg Met Phe Gln Ile
     435                 440                 445

 cag tac aat ggt act tat gat gac acc ctt gtt tac aga atg ata cct     2470
 Gln Tyr Asn Gly Thr Tyr Asp Asp Thr Leu Val Tyr Arg Met Ile Pro
 450                 455                 460                 465

 cct acg agc aaa act ttt ctg gtc aat aat ctg gct gct gga act atg     2518
 Pro Thr Ser Lys Thr Phe Leu Val Asn Asn Leu Ala Ala Gly Thr Met
                 470                 475                 480

 tat gac ttg tgt gtc ttg gcc ata tat gat gat ggc atc act tcc ctc     2566
 Tyr Asp Leu Cys Val Leu Ala Ile Tyr Asp Asp Gly Ile Thr Ser Leu
             485                 490                 495

 act gcc aca aga gtc gtg ggt tgc atc cag ttt act acg gaa cag gat     2614
 Thr Ala Thr Arg Val Val Gly Cys Ile Gln Phe Thr Thr Glu Gln Asp
         500                 505                 510

 tat gtg cgt tgc cat ttc atg cag tct cag ttt ttg gga ggc acc atg     2662
 Tyr Val Arg Cys His Phe Met Gln Ser Gln Phe Leu Gly Gly Thr Met
     515                 520                 525

 att att att att ggt gga atc att gta gca tct gtg ctg gta ttc atc     2710
 Ile Ile Ile Ile Gly Gly Ile Ile Val Ala Ser Val Leu Val Phe Ile
 530                 535                 540                 545

 att att ctg atg atc cgg tat aag gtt tgc aac aat aat ggg caa cac     2758
 Ile Ile Leu Met Ile Arg Tyr Lys Val Cys Asn Asn Asn Gly Gln His
                 550                 555                 560

 aag gtc acc aag gtt agc aat gtt tat tcc caa act aac ggg gct caa     2806
 Lys Val Thr Lys Val Ser Asn Val Tyr Ser Gln Thr Asn Gly Ala Gln
             565                 570                 575

 ata caa ggc tgt agt gta acg ctg ccc cag tcc gtg tcc aaa caa gct     2854
 Ile Gln Gly Cys Ser Val Thr Leu Pro Gln Ser Val Ser Lys Gln Ala
         580                 585                 590

 gtg gga cac gaa gag aat gcc cag tgt tgt aaa gct acc agt gac aat     2902
 Val Gly His Glu Glu Asn Ala Gln Cys Cys Lys Ala Thr Ser Asp Asn
     595                 600                 605

 gtg att caa tct tca gaa act tgt tcg agt cag gac tcc tct acc act     2950
 Val Ile Gln Ser Ser Glu Thr Cys Ser Ser Gln Asp Ser Ser Thr Thr
 610                 615                 620                 625

 acc tct gct ttg cct cct tcc tgg act tca agc act tct gtg tcc caa     2998
 Thr Ser Ala Leu Pro Pro Ser Trp Thr Ser Ser Thr Ser Val Ser Gln
                 630                 635                 640

 aag cag aaa aga aag act ggc aca aag cca agt aca gaa cca cag aat     3046
 Lys Gln Lys Arg Lys Thr Gly Thr Lys Pro Ser Thr Glu Pro Gln Asn
             645                 650                 655

 gaa gcc gtc aca aat gtt gaa tcc caa aac act aac agg aac aac tca     3094
 Glu Ala Val Thr Asn Val Glu Ser Gln Asn Thr Asn Arg Asn Asn Ser
         660                 665                 670

 act gcc ttg cag tta gct agc cgt cct ccc gat tct gtc aca gag ggg     3142
 Thr Ala Leu Gln Leu Ala Ser Arg Pro Pro Asp Ser Val Thr Glu Gly
     675                 680                 685

 ccc acg tct aaa aga gca cat ata aag cca aat gct ttg ctg act aat     3190
 Pro Thr Ser Lys Arg Ala His Ile Lys Pro Asn Ala Leu Leu Thr Asn
 690                 695                 700                 705

 gtt gac cag att gtc cag gaa aca cag agg ctg gag tta atc tga aga     3238
 Val Asp Gln Ile Val Gln Glu Thr Gln Arg Leu Glu Leu Ile 
                 710                 715

 gcaccacttc tcctctctct cctgaaaaaa tttgccactg atatttttac tggataaaat   3298

 tcaaaaatgt ttcaattcac aaaggctaat tgttgaactg gtgtcgtaga agaaattgtc   3358

 tacaggagcc aaggtgaaag tctctgatga cggcggaact ggctccatta gaccatggtt   3418

 catcctcttt taaaaccaaa tttttttttc ttctggccta caagtatttt ttttttaaaa   3478

 aagaaaaaaa gcctacattg gcatcaagtt ctgtatcaat ccatcttaca ttgccatcca   3538

 tgatttaaca gactgtagaa tcttgaataa tctatatcac tttaacaaat aaatgtttta   3598

 ctatgac                                                             3605




      <210> 74
      <211> 3776
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (173)..(2512)

      <400> 74
 cctttactac agaataaata ttaatacttg ttaagcaaac aagtgaaatt atttctctat     60

 tctagattgc atacaaatat tattctagta ggaatatgaa tatgaattaa atcactggat    120

 gctaacattc tattttgtgt cttccgttac aggctcttaa acctgatcta ca    atg     175
                                                              Met
                                                                1

 gaa aaa att ctt ttt tat ctg ttt ctc att ggc ata gca gtg aaa gct      223
 Glu Lys Ile Leu Phe Tyr Leu Phe Leu Ile Gly Ile Ala Val Lys Ala
               5                  10                  15

 cag atc tgt cca aag cgt tgt gtc tgt cag att ttg tct cct aat ctt      271
 Gln Ile Cys Pro Lys Arg Cys Val Cys Gln Ile Leu Ser Pro Asn Leu
          20                  25                  30

 gca acc ctt tgt gcc aag aaa ggg ctt tta ttt gtt cca cca aac att      319
 Ala Thr Leu Cys Ala Lys Lys Gly Leu Leu Phe Val Pro Pro Asn Ile
      35                  40                  45

 gac aga aga act gtg gaa ctg cgg ttg gca gac aat ttt gtt aca aat      367
 Asp Arg Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Val Thr Asn
  50                  55                  60                  65

 att aaa agg aaa gat ttt gcc aat atg acc agc ttg gtg gac ctg act      415
 Ile Lys Arg Lys Asp Phe Ala Asn Met Thr Ser Leu Val Asp Leu Thr
                  70                  75                  80

 cta tcc agg aat aca ata agt ttt att aca cct cat gct ttc gct gac      463
 Leu Ser Arg Asn Thr Ile Ser Phe Ile Thr Pro His Ala Phe Ala Asp
              85                  90                  95

 cta cga aat ttg agg gct ttg cat ttg aat agc aac aga ttg act aaa      511
 Leu Arg Asn Leu Arg Ala Leu His Leu Asn Ser Asn Arg Leu Thr Lys
         100                 105                 110

 att aca aat gat atg ttc agt ggt ctt tcc aat ctt cat cat ttg ata      559
 Ile Thr Asn Asp Met Phe Ser Gly Leu Ser Asn Leu His His Leu Ile
     115                 120                 125

 ctg aac aac aat cag ctg act tta att tcc tct aca gcg ttt gat gat      607
 Leu Asn Asn Asn Gln Leu Thr Leu Ile Ser Ser Thr Ala Phe Asp Asp
 130                 135                 140                 145

 gtc ttc gcc ctt gag gag ctg gat ctg tcc tat aat aat cta gaa acc      655
 Val Phe Ala Leu Glu Glu Leu Asp Leu Ser Tyr Asn Asn Leu Glu Thr
                 150                 155                 160

 att cct tgg gat gct gtt gag aag atg gtt agc ttg cat acc ctt agt      703
 Ile Pro Trp Asp Ala Val Glu Lys Met Val Ser Leu His Thr Leu Ser
             165                 170                 175

 ttg gat cac aat atg att gat aac att cct aag ggg acc ttc tcc cat      751
 Leu Asp His Asn Met Ile Asp Asn Ile Pro Lys Gly Thr Phe Ser His
         180                 185                 190

 ttg cac aag atg act cgg tta gat gtg aca tca aat aaa ttg cag aag      799
 Leu His Lys Met Thr Arg Leu Asp Val Thr Ser Asn Lys Leu Gln Lys
     195                 200                 205

 cta cca cct gac cct ctc ttt cag cga gct cag gta cta gca acc tca      847
 Leu Pro Pro Asp Pro Leu Phe Gln Arg Ala Gln Val Leu Ala Thr Ser
 210                 215                 220                 225

 gga atc ata agc cca tct act ttt gca tta agt ttt ggt gga aac ccc      895
 Gly Ile Ile Ser Pro Ser Thr Phe Ala Leu Ser Phe Gly Gly Asn Pro
                 230                 235                 240

 ttg cat tgc aat tgt gaa ttg ttg tgg ttg agg cgt ctg tcc aga gaa      943
 Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Ser Arg Glu
             245                 250                 255

 gat gac tta gag acc tgt gct tct cct cca ctt tta act ggc cgc tac      991
 Asp Asp Leu Glu Thr Cys Ala Ser Pro Pro Leu Leu Thr Gly Arg Tyr
         260                 265                 270

 ttt tgg tca att cct gaa gaa gag ttt ttg tgt gag cct cct ctc att     1039
 Phe Trp Ser Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu Ile
     275                 280                 285

 act cgt cat aca cat gag atg aga gtc ctg gag gga caa agg gca aca     1087
 Thr Arg His Thr His Glu Met Arg Val Leu Glu Gly Gln Arg Ala Thr
 290                 295                 300                 305

 ctg agg tgc aaa gcc agg gga gac cct gag cct gca att cac tgg att     1135
 Leu Arg Cys Lys Ala Arg Gly Asp Pro Glu Pro Ala Ile His Trp Ile
                 310                 315                 320

 tct cct gaa ggg aag ctt att tca aat gca aca aga tct ctg gtg tat     1183
 Ser Pro Glu Gly Lys Leu Ile Ser Asn Ala Thr Arg Ser Leu Val Tyr
             325                 330                 335

 gat aac gga aca ctt gac att ctt atc aca act gta aag gat aca ggt     1231
 Asp Asn Gly Thr Leu Asp Ile Leu Ile Thr Thr Val Lys Asp Thr Gly
         340                 345                 350

 gct ttt acc tgc att gct tcc aat cct gct ggg gaa gca aca caa ata     1279
 Ala Phe Thr Cys Ile Ala Ser Asn Pro Ala Gly Glu Ala Thr Gln Ile
     355                 360                 365

 gtg gat ctt cat ata att aag ctc cct cac tta cta aat agt aca aac     1327
 Val Asp Leu His Ile Ile Lys Leu Pro His Leu Leu Asn Ser Thr Asn
 370                 375                 380                 385

 cat atc cat gag cct gat cct ggt tct tca gat atc tca act tct acc     1375
 His Ile His Glu Pro Asp Pro Gly Ser Ser Asp Ile Ser Thr Ser Thr
                 390                 395                 400

 aag tca ggt tct aat aca agc agt agt aat ggt gat act aaa ttg agt     1423
 Lys Ser Gly Ser Asn Thr Ser Ser Ser Asn Gly Asp Thr Lys Leu Ser
             405                 410                 415

 caa gat aaa att gtg gtg gca gaa gct aca tca tca acg gca cta ctt     1471
 Gln Asp Lys Ile Val Val Ala Glu Ala Thr Ser Ser Thr Ala Leu Leu
         420                 425                 430

 aaa ttt aat ttt caa aga aat atc cct gga ata cgt atg ttt caa atc     1519
 Lys Phe Asn Phe Gln Arg Asn Ile Pro Gly Ile Arg Met Phe Gln Ile
     435                 440                 445

 cag tac aat ggt act tat gat gac acc ctt gtt tac agg ttg tcc ctc     1567
 Gln Tyr Asn Gly Thr Tyr Asp Asp Thr Leu Val Tyr Arg Leu Ser Leu
 450                 455                 460                 465

 aga atg ata cct cct acg agc aaa act ttt ctg gtc aat aat ctg gct     1615
 Arg Met Ile Pro Pro Thr Ser Lys Thr Phe Leu Val Asn Asn Leu Ala
                 470                 475                 480

 gct gga act atg tat gac ttg tgt gtc ttg gcc ata tat gat gat ggc     1663
 Ala Gly Thr Met Tyr Asp Leu Cys Val Leu Ala Ile Tyr Asp Asp Gly
             485                 490                 495

 atc act tcc ctc act gcc aca aga gtc gtg ggt tgc atc cag ttt act     1711
 Ile Thr Ser Leu Thr Ala Thr Arg Val Val Gly Cys Ile Gln Phe Thr
         500                 505                 510

 acg gaa cag gat tat gtg cgt tgc cat ttc atg cag tct cag ttt ttg     1759
 Thr Glu Gln Asp Tyr Val Arg Cys His Phe Met Gln Ser Gln Phe Leu
     515                 520                 525

 gga ggc acc atg att att att att ggt gga atc att gta gca tct gtg     1807
 Gly Gly Thr Met Ile Ile Ile Ile Gly Gly Ile Ile Val Ala Ser Val
 530                 535                 540                 545

 ctg gta ttc atc att att ctg atg atc cgg tat aag gtt tgc aac aat     1855
 Leu Val Phe Ile Ile Ile Leu Met Ile Arg Tyr Lys Val Cys Asn Asn
                 550                 555                 560

 aat ggg caa cac aag gtc acc aag gtt agc aat gtt tat tcc caa act     1903
 Asn Gly Gln His Lys Val Thr Lys Val Ser Asn Val Tyr Ser Gln Thr
             565                 570                 575

 aac ggg gct caa ata caa ggc tgt agt gta acg ctg ccc cag tcc gtg     1951
 Asn Gly Ala Gln Ile Gln Gly Cys Ser Val Thr Leu Pro Gln Ser Val
         580                 585                 590

 tcc aaa caa gct gtg gga cac gaa gag aat gcc cag tgt tgt aaa gct     1999
 Ser Lys Gln Ala Val Gly His Glu Glu Asn Ala Gln Cys Cys Lys Ala
     595                 600                 605

 acc agt gac aat gtg att caa tct tca gaa act tgt tcg agt cag gac     2047
 Thr Ser Asp Asn Val Ile Gln Ser Ser Glu Thr Cys Ser Ser Gln Asp
 610                 615                 620                 625

 tcc tct acc act acc tct gct ttg cct cct tcc tgg act tca agc act     2095
 Ser Ser Thr Thr Thr Ser Ala Leu Pro Pro Ser Trp Thr Ser Ser Thr
                 630                 635                 640

 tct gtg tcc caa aag cag aaa aga aag act ggc aca aag cca agt aca     2143
 Ser Val Ser Gln Lys Gln Lys Arg Lys Thr Gly Thr Lys Pro Ser Thr
             645                 650                 655

 gaa cca cag aat gaa gcc gtc aca aat gtt gaa tcc caa aac act aac     2191
 Glu Pro Gln Asn Glu Ala Val Thr Asn Val Glu Ser Gln Asn Thr Asn
         660                 665                 670

 agg aac aac tca act gcc ttg cag tta gct agc cgt cct ccc gat tct     2239
 Arg Asn Asn Ser Thr Ala Leu Gln Leu Ala Ser Arg Pro Pro Asp Ser
     675                 680                 685

 gtc aca gag ggg ccc acg tct aaa aga gca cat ata aag cca agt aag     2287
 Val Thr Glu Gly Pro Thr Ser Lys Arg Ala His Ile Lys Pro Ser Lys
 690                 695                 700                 705

 ttt atc act ttg cct gct gag aga tcc gga gca agg cac aag tac tcc     2335
 Phe Ile Thr Leu Pro Ala Glu Arg Ser Gly Ala Arg His Lys Tyr Ser
                 710                 715                 720

 ctc aat gga gaa tta aag gaa tac tat tgt tat att aac tcg ccg aac     2383
 Leu Asn Gly Glu Leu Lys Glu Tyr Tyr Cys Tyr Ile Asn Ser Pro Asn
             725                 730                 735

 aca tgt gga ctg ttt cct aaa aga agc atg tct atg aat gtg atg ttt     2431
 Thr Cys Gly Leu Phe Pro Lys Arg Ser Met Ser Met Asn Val Met Phe
         740                 745                 750

 att cag tct gac tgt tct gat ggt cat agt gcg aaa ggc aac ttc tca     2479
 Ile Gln Ser Asp Cys Ser Asp Gly His Ser Ala Lys Gly Asn Phe Ser
     755                 760                 765

 aat tct gag gga cta ctg gaa agc tct gtg taa tttataat ttctttttca     2530
 Asn Ser Glu Gly Leu Leu Glu Ser Ser Val 
 770                 775

 tgaaaaatca ttttgagaac tcacatagaa gattggaatt tgcaattcca atgctgtgta   2590

 taaatcaacc ttctcaggta cagtatatat atatacacat atataactat atatatgtat   2650

 gtatgtatat gtatactgga aggaaacata aataaaatgg ataagggaaa aagcatgaca   2710

 tagcagcagt gcctttccct attctaggac caactcctag gactagcaac agcagattaa   2770

 aaaaatgaaa attgttgtag aaaaaagtat tgcataaaaa atgatatttc tctaatttta   2830

 caaagggcca cctatggata attgatattt ttaataagta gactgtatat tttctttcaa   2890

 tggtaatagt gtttcctttg tttttaggga aatgttgtag agaacaactt catgttgcta   2950

 aattatttaa aatacaatat tcaattagta taccgagtta atgttaaaat tagttcactt   3010

 ctaaacaaca tccttggtgc aggtgcctta atggttgtaa gatatttctc ctctatgata   3070

 cacctttttc agtggaaaga agaaagtgca atttatttcg catttatgaa aactctaatc   3130

 agttttcagt cacaggctac aaattcctat gcatctacat ggacatatga agatgttttc   3190

 attcatttaa tacacatttt ttgaatgaat gagttttatg ttgttcttaa tacaagataa   3250

 agagggagac aaacatacaa gactgccttt atcaaagggg tgtttatttt tatcaccaag   3310

 taaaatttaa aaacttctaa tggtgttctc attatattta taagtcataa aagtcattgc   3370

 tcattaagca gatagtggat tttttttttc ccatttgcac tatagttttt gcatttgaat   3430

 gttttccttt taaagtaaat gcatttgcta ttttaaccaa aaactgtgat aaatctaact   3490

 agaaatcatg ctgcttagtg agaatacata attttttaaa acaggatttt aaatttagta   3550

 gaaactaatg ttgctcctgg ataatatgga attattagaa atttactgaa attaaggtct   3610

 atagataaat gtttctattc actccttgaa aaacttaatt atataataat ttgatggtgt   3670

 tctattaaag atctataaac agttaccatc aaagaggttt tattttgttt tgttttgaga   3730

 ataaggctca cctgagaact gacccattgc tttgcacaaa agaaat                  3776




      <210> 75
      <211> 5714
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (272)..(4312)

      <400> 75
 ctgcacgacc ggtccggaat tcccgggtcg acgatttcgt gatcatagct gggggaggct     60

 gagcgtggga gcggtgctgc cagtcctgcc tgaaaacgcg aaatgagtct tgcttggttc    120

 tccctccact gggcgtgaga gcccctgccc aggaggccca ggacaaatgg ccccatagtg    180

 gaaactggga agcttttagg catctgatca gagcgggagc cagccggggg accacagtgc    240

 tggacaggcc aaccaactca aacttgaaga c   atg aaa tcc cca agg aga acc     292
                                      Met Lys Ser Pro Arg Arg Thr
                                        1               5

 act ttg tgc ctc atg ttt att gtg att tat tct tcc aaa gct gca ctg      340
 Thr Leu Cys Leu Met Phe Ile Val Ile Tyr Ser Ser Lys Ala Ala Leu
          10                  15                  20

 aac tgg aat tac gag tct act att cat cct ttg agt ctt cat gaa cat      388
 Asn Trp Asn Tyr Glu Ser Thr Ile His Pro Leu Ser Leu His Glu His
      25                  30                  35

 gaa cca gct ggt gaa gag gca ctg agg caa aaa cga gcc gtt gcc aca      436
 Glu Pro Ala Gly Glu Glu Ala Leu Arg Gln Lys Arg Ala Val Ala Thr
  40                  45                  50                  55

 aaa agt cct acg gct gaa gaa tac act gtt aat att gag atc agt ttt      484
 Lys Ser Pro Thr Ala Glu Glu Tyr Thr Val Asn Ile Glu Ile Ser Phe
                  60                  65                  70

 gaa aat gca tcc ttc ctg gat cct atc aaa gcc tac ttg aac agc ctc      532
 Glu Asn Ala Ser Phe Leu Asp Pro Ile Lys Ala Tyr Leu Asn Ser Leu
              75                  80                  85

 agt ttt cca att cat ggg aat aac act gac caa att act gac att ttg      580
 Ser Phe Pro Ile His Gly Asn Asn Thr Asp Gln Ile Thr Asp Ile Leu
          90                  95                 100

 agc ata aat gtg aca aca gtc tgc aga cct gct gga aat gaa atc tgg      628
 Ser Ile Asn Val Thr Thr Val Cys Arg Pro Ala Gly Asn Glu Ile Trp
     105                 110                 115

 tgc tcc tgc gag aca ggt tat ggg tgg cct cgg gaa agg tgt ctt cac      676
 Cys Ser Cys Glu Thr Gly Tyr Gly Trp Pro Arg Glu Arg Cys Leu His
 120                 125                 130                 135

 aat ctc att tgt caa gag cgt gac gtc ttc ctc cca ggg cac cat agc      724
 Asn Leu Ile Cys Gln Glu Arg Asp Val Phe Leu Pro Gly His His Ser
                 140                 145                 150

 agt tgc ctt aaa gaa ctg cct ccc aat gga cct ttt tgc ctg ctt cag      772
 Ser Cys Leu Lys Glu Leu Pro Pro Asn Gly Pro Phe Cys Leu Leu Gln
             155                 160                 165

 gaa gat gtt acc ctg aac atg aga gtc aga cta aat gta ggc ttt caa      820
 Glu Asp Val Thr Leu Asn Met Arg Val Arg Leu Asn Val Gly Phe Gln
         170                 175                 180

 gaa gac ctc atg aac act tcc tcc gcc ctc tat agg tcc tac aag acc      868
 Glu Asp Leu Met Asn Thr Ser Ser Ala Leu Tyr Arg Ser Tyr Lys Thr
     185                 190                 195

 gac ttg gaa aca gcg ttc cgg aag ggt tac gga att tta cca ggc ttc      916
 Asp Leu Glu Thr Ala Phe Arg Lys Gly Tyr Gly Ile Leu Pro Gly Phe
 200                 205                 210                 215

 aag ggc gtg act gtg aca ggg ttc aag tct gga agt gtg gtt gtg aca      964
 Lys Gly Val Thr Val Thr Gly Phe Lys Ser Gly Ser Val Val Val Thr
                 220                 225                 230

 tat gaa gtc aag act aca cca cca tca ctt gag tta ata cat aaa gcc     1012
 Tyr Glu Val Lys Thr Thr Pro Pro Ser Leu Glu Leu Ile His Lys Ala
             235                 240                 245

 aat gaa caa gtt gta cag agc ctc aat cag acc tac aaa atg gac tac     1060
 Asn Glu Gln Val Val Gln Ser Leu Asn Gln Thr Tyr Lys Met Asp Tyr
         250                 255                 260

 aac tcc ttt caa gca gtt act atc aat gaa agc aat ttc ttt gtc aca     1108
 Asn Ser Phe Gln Ala Val Thr Ile Asn Glu Ser Asn Phe Phe Val Thr
     265                 270                 275

 cca gaa atc atc ttt gaa ggg gac aca gtc agt ctg gtg tgt gaa aag     1156
 Pro Glu Ile Ile Phe Glu Gly Asp Thr Val Ser Leu Val Cys Glu Lys
 280                 285                 290                 295

 gaa gtt ttg tcc tcc aat gtg tct tgg cgc tat gaa gaa cag cag ttg     1204
 Glu Val Leu Ser Ser Asn Val Ser Trp Arg Tyr Glu Glu Gln Gln Leu
                 300                 305                 310

 gaa atc cag aac agc agc aga ttc tcg att tac acc gca ctt ttc aac     1252
 Glu Ile Gln Asn Ser Ser Arg Phe Ser Ile Tyr Thr Ala Leu Phe Asn
             315                 320                 325

 aac atg act tcg gtg tcc aag ctc acc atc cac aac atc act cca ggt     1300
 Asn Met Thr Ser Val Ser Lys Leu Thr Ile His Asn Ile Thr Pro Gly
         330                 335                 340

 gat gca ggt gaa tat gtt tgc aaa ctg ata tta gac att ttt gaa tat     1348
 Asp Ala Gly Glu Tyr Val Cys Lys Leu Ile Leu Asp Ile Phe Glu Tyr
     345                 350                 355

 gag tgc aag aag aaa ata gat gtt atg ccc atc caa att ttg gca aat     1396
 Glu Cys Lys Lys Lys Ile Asp Val Met Pro Ile Gln Ile Leu Ala Asn
 360                 365                 370                 375

 gaa gaa atg aag gtg atg tgc gac aac aat cct gta tct ttg aac tgc     1444
 Glu Glu Met Lys Val Met Cys Asp Asn Asn Pro Val Ser Leu Asn Cys
                 380                 385                 390

 tgc agt cag ggt aat gtt aat tgg agc aaa gta gaa tgg aag cag gaa     1492
 Cys Ser Gln Gly Asn Val Asn Trp Ser Lys Val Glu Trp Lys Gln Glu
             395                 400                 405

 gga aaa ata aat att cca gga acc cct gag aca gac ata gat tct agc     1540
 Gly Lys Ile Asn Ile Pro Gly Thr Pro Glu Thr Asp Ile Asp Ser Ser
         410                 415                 420

 tgc agc aga tac acc ctc aag gct gat gga acc cag tgc cca agc ggg     1588
 Cys Ser Arg Tyr Thr Leu Lys Ala Asp Gly Thr Gln Cys Pro Ser Gly
     425                 430                 435

 tcg tct gga aca aca gtc atc tac act tgt gag ttc atc agt gcc tat     1636
 Ser Ser Gly Thr Thr Val Ile Tyr Thr Cys Glu Phe Ile Ser Ala Tyr
 440                 445                 450                 455

 gga gcc aga ggc agt gca aac ata aaa gtg aca ttc atc tct gtg gcc     1684
 Gly Ala Arg Gly Ser Ala Asn Ile Lys Val Thr Phe Ile Ser Val Ala
                 460                 465                 470

 aat cta aca ata acc ccg gac cca att tct gtt tct gag gga caa aac     1732
 Asn Leu Thr Ile Thr Pro Asp Pro Ile Ser Val Ser Glu Gly Gln Asn
             475                 480                 485

 ttt tct ata aaa tgc atc agt gat gtg agt aac tat gat gag gtt tat     1780
 Phe Ser Ile Lys Cys Ile Ser Asp Val Ser Asn Tyr Asp Glu Val Tyr
         490                 495                 500

 tgg aac act tct gct gga att aaa ata tac caa aga ttt tat acc acg     1828
 Trp Asn Thr Ser Ala Gly Ile Lys Ile Tyr Gln Arg Phe Tyr Thr Thr
     505                 510                 515

 agg agg tat ctt gat gga gca gaa tca gta ctg aca gtc aag acc tcg     1876
 Arg Arg Tyr Leu Asp Gly Ala Glu Ser Val Leu Thr Val Lys Thr Ser
 520                 525                 530                 535

 acc agg gag tgg aat gga acc tat cac tgc ata ttt aga tat aag aat     1924
 Thr Arg Glu Trp Asn Gly Thr Tyr His Cys Ile Phe Arg Tyr Lys Asn
                 540                 545                 550

 tca tac agt att gca acc aaa gac gtc att gtt cac ccg ctg cct cta     1972
 Ser Tyr Ser Ile Ala Thr Lys Asp Val Ile Val His Pro Leu Pro Leu
             555                 560                 565

 aag ctg aac atc atg gtt gat cct ttg gaa gct act gtt tca tgc agt     2020
 Lys Leu Asn Ile Met Val Asp Pro Leu Glu Ala Thr Val Ser Cys Ser
         570                 575                 580

 ggt tcc cat cac atc aag tgc tgc ata gag gag gat gga gac tac aaa     2068
 Gly Ser His His Ile Lys Cys Cys Ile Glu Glu Asp Gly Asp Tyr Lys
     585                 590                 595

 gtt act ttc cat atg ggt tcc tca tcc ctt cct gct gca aaa gaa gtt     2116
 Val Thr Phe His Met Gly Ser Ser Ser Leu Pro Ala Ala Lys Glu Val
 600                 605                 610                 615

 aac aaa aaa caa gtg tgc tac aaa cac aat ttc aat gca agc tca gtt     2164
 Asn Lys Lys Gln Val Cys Tyr Lys His Asn Phe Asn Ala Ser Ser Val
                 620                 625                 630

 tcc tgg tgt tca aaa act gtt gat gtg tgt tgt cac ttt acc aat gct     2212
 Ser Trp Cys Ser Lys Thr Val Asp Val Cys Cys His Phe Thr Asn Ala
             635                 640                 645

 gct aat aat tca gtt tgg agc cca tct atg aag ctg aat ctg gtt cct     2260
 Ala Asn Asn Ser Val Trp Ser Pro Ser Met Lys Leu Asn Leu Val Pro
         650                 655                 660

 ggg gaa aac atc aca tgc cag gat ccc gta ata ggt gtc gga gag ccg     2308
 Gly Glu Asn Ile Thr Cys Gln Asp Pro Val Ile Gly Val Gly Glu Pro
     665                 670                 675

 ggg aaa gtc atc cag aag cta tgc cgg ttc tca aac gtt ccc agc agc     2356
 Gly Lys Val Ile Gln Lys Leu Cys Arg Phe Ser Asn Val Pro Ser Ser
 680                 685                 690                 695

 cct gag agt ccc att ggc ggg acc atc act tac aaa tgt gta ggc tcc     2404
 Pro Glu Ser Pro Ile Gly Gly Thr Ile Thr Tyr Lys Cys Val Gly Ser
                 700                 705                 710

 cag tgg gag gag aag aga aat gac tgc atc tct gcc cca ata aac agt     2452
 Gln Trp Glu Glu Lys Arg Asn Asp Cys Ile Ser Ala Pro Ile Asn Ser
             715                 720                 725

 ctg ctc cag atg gct aag gct ttg atc aag agc ccc tct cag gat gag     2500
 Leu Leu Gln Met Ala Lys Ala Leu Ile Lys Ser Pro Ser Gln Asp Glu
         730                 735                 740

 atg ctc cct aca tac ctg aag gat ctt tct att agc ata gac aaa gcg     2548
 Met Leu Pro Thr Tyr Leu Lys Asp Leu Ser Ile Ser Ile Asp Lys Ala
     745                 750                 755

 gaa cat gaa atc agc tct tct cct ggg agt ctg gga gcc att att aac     2596
 Glu His Glu Ile Ser Ser Ser Pro Gly Ser Leu Gly Ala Ile Ile Asn
 760                 765                 770                 775

 atc ctt gat ctg ctc tca aca gtt cca acc caa gta aat tca gaa atg     2644
 Ile Leu Asp Leu Leu Ser Thr Val Pro Thr Gln Val Asn Ser Glu Met
                 780                 785                 790

 atg acg cac gtg ctc tct acg gtt aat gtc atc ctt ggc aag ccc gtc     2692
 Met Thr His Val Leu Ser Thr Val Asn Val Ile Leu Gly Lys Pro Val
             795                 800                 805

 ttg aac acc tgg aag gtt tta caa cag caa tgg acc aat cag agt tca     2740
 Leu Asn Thr Trp Lys Val Leu Gln Gln Gln Trp Thr Asn Gln Ser Ser
         810                 815                 820

 cag cta cta cat tca gtg gaa aga ttt tcc caa gca tta cag tca gga     2788
 Gln Leu Leu His Ser Val Glu Arg Phe Ser Gln Ala Leu Gln Ser Gly
     825                 830                 835

 gat agc cct cct ttg tcc ttc tcc caa act aat gtg cag atg agc agc     2836
 Asp Ser Pro Pro Leu Ser Phe Ser Gln Thr Asn Val Gln Met Ser Ser
 840                 845                 850                 855

 acg gta atc aag tcc agc cac cca gaa acc tat caa cag agg ttt gtt     2884
 Thr Val Ile Lys Ser Ser His Pro Glu Thr Tyr Gln Gln Arg Phe Val
                 860                 865                 870

 ttc cca tac ttt gac ctc tgg ggc aat gtg gtc att gac aag agc tat     2932
 Phe Pro Tyr Phe Asp Leu Trp Gly Asn Val Val Ile Asp Lys Ser Tyr
             875                 880                 885

 cta gaa aac ttg cag tcg gat tcg tct att gtc acc atg gct ttc cca     2980
 Leu Glu Asn Leu Gln Ser Asp Ser Ser Ile Val Thr Met Ala Phe Pro
         890                 895                 900

 act ctc caa gcc atc ctt gct cag gat atc cag gaa aat aac ttt gca     3028
 Thr Leu Gln Ala Ile Leu Ala Gln Asp Ile Gln Glu Asn Asn Phe Ala
     905                 910                 915

 gag agc tta gtg atg aca acc act gtc agc cac aat acg act atg cca     3076
 Glu Ser Leu Val Met Thr Thr Thr Val Ser His Asn Thr Thr Met Pro
 920                 925                 930                 935

 ttc agg att tca atg act ttt aag aac aat agc cct tca ggc ggc gaa     3124
 Phe Arg Ile Ser Met Thr Phe Lys Asn Asn Ser Pro Ser Gly Gly Glu
                 940                 945                 950

 acg aag tgt gtc ttc tgg aac ttc agg ctt gcc aac aac aca ggg ggg     3172
 Thr Lys Cys Val Phe Trp Asn Phe Arg Leu Ala Asn Asn Thr Gly Gly
             955                 960                 965

 tgg gac agc agt ggg tgc tat gtt gaa gaa ggt gat ggg gac aat gtc     3220
 Trp Asp Ser Ser Gly Cys Tyr Val Glu Glu Gly Asp Gly Asp Asn Val
         970                 975                 980

 acc tgt atc tgt gac cac cta aca tca ttc tcc atc ctc atg tcc cct     3268
 Thr Cys Ile Cys Asp His Leu Thr Ser Phe Ser Ile Leu Met Ser Pro
     985                 990                 995

 gac tcc cca gat cct agt tct ctc ctg gga ata ctc ctg gat att att     3316
 Asp Ser Pro Asp Pro Ser Ser Leu Leu Gly Ile Leu Leu Asp Ile Ile
1000                1005                1010                1015

 tct tat gtt ggg gtg ggc ttt tcc atc ttg agc ttg gca gcc tgt cta     3364
 Ser Tyr Val Gly Val Gly Phe Ser Ile Leu Ser Leu Ala Ala Cys Leu
                1020                1025                1030

 gtt gtg gaa gct gtg gtg tgg aaa tcg gtg acc aag aat cgg act tct     3412
 Val Val Glu Ala Val Val Trp Lys Ser Val Thr Lys Asn Arg Thr Ser
            1035                1040                1045

 tat atg cgc cac acc tgc ata gtg aat atc gct gcc tcc ctt ctg gtc     3460
 Tyr Met Arg His Thr Cys Ile Val Asn Ile Ala Ala Ser Leu Leu Val
        1050                1055                1060

 gcc aac acc tgg ttc att gtg gtc gct gcc atc cag gac aat cgc tac     3508
 Ala Asn Thr Trp Phe Ile Val Val Ala Ala Ile Gln Asp Asn Arg Tyr
    1065                1070                1075

 ata ctc tgc aag aca gcc tgt gtg gct gcc acc ttc ttc atc cac ttc     3556
 Ile Leu Cys Lys Thr Ala Cys Val Ala Ala Thr Phe Phe Ile His Phe
1080                1085                1090                1095

 ttc tac ctc agc gtc ttc ttc tgg atg ctg aca ctg ggc ctc atg ctg     3604
 Phe Tyr Leu Ser Val Phe Phe Trp Met Leu Thr Leu Gly Leu Met Leu
                1100                1105                1110

 ttc tat cgc ctg gtt ttc att ctg cat gaa aca agc agg tcc act cag     3652
 Phe Tyr Arg Leu Val Phe Ile Leu His Glu Thr Ser Arg Ser Thr Gln
            1115                1120                1125

 aaa gcc att gcc ttc tgt ctt ggc tat ggc tgc cca ctt gcc atc tcg     3700
 Lys Ala Ile Ala Phe Cys Leu Gly Tyr Gly Cys Pro Leu Ala Ile Ser
        1130                1135                1140

 gtc atc acg ctg gga gcc acc cag ccc cgg gaa gtc tat acg agg aag     3748
 Val Ile Thr Leu Gly Ala Thr Gln Pro Arg Glu Val Tyr Thr Arg Lys
    1145                1150                1155

 aat gtc tgt tgg ctc aac tgg gag gac acc aag gcc ctg ctg gct ttc     3796
 Asn Val Cys Trp Leu Asn Trp Glu Asp Thr Lys Ala Leu Leu Ala Phe
1160                1165                1170                1175

 gcc atc cca gca ctg atc att gtg gtg gtg aac ata acc atc act att     3844
 Ala Ile Pro Ala Leu Ile Ile Val Val Val Asn Ile Thr Ile Thr Ile
                1180                1185                1190

 gtg gtc atc acc aag atc ctg agg cct tcc att gga gac aag cca tgc     3892
 Val Val Ile Thr Lys Ile Leu Arg Pro Ser Ile Gly Asp Lys Pro Cys
            1195                1200                1205

 aag cag gag aag agc agc ctg ttt cag atc agc aag agc att ggg gtc     3940
 Lys Gln Glu Lys Ser Ser Leu Phe Gln Ile Ser Lys Ser Ile Gly Val
        1210                1215                1220

 ctc aca cca ctc ttg ggc ctc act tgg ggt ttt ggt ctc acc act gtg     3988
 Leu Thr Pro Leu Leu Gly Leu Thr Trp Gly Phe Gly Leu Thr Thr Val
    1225                1230                1235

 ttc cca ggg acc aac ctt gtg ttc cat atc ata ttt gcc atc ctc aat     4036
 Phe Pro Gly Thr Asn Leu Val Phe His Ile Ile Phe Ala Ile Leu Asn
1240                1245                1250                1255

 gtc ttc cag gga tta ttc att tta ctc ttt gga tgc ctc tgg gat ctg     4084
 Val Phe Gln Gly Leu Phe Ile Leu Leu Phe Gly Cys Leu Trp Asp Leu
                1260                1265                1270

 aag gta cag gaa gct ttg ctg aat aag ttt tca ttg tcg aga tgg tct     4132
 Lys Val Gln Glu Ala Leu Leu Asn Lys Phe Ser Leu Ser Arg Trp Ser
            1275                1280                1285

 tca cag cac tca aag tca aca tcc ctg ggt tca tcc aca cct gtg ttt     4180
 Ser Gln His Ser Lys Ser Thr Ser Leu Gly Ser Ser Thr Pro Val Phe
        1290                1295                1300

 tct atg agt tct cca ata tca agg aga ttt aac aat ttg ttt ggt aaa     4228
 Ser Met Ser Ser Pro Ile Ser Arg Arg Phe Asn Asn Leu Phe Gly Lys
    1305                1310                1315

 aca gga acg tat aat gtt tcc acc cca gaa gca acc agc tca tcc ctg     4276
 Thr Gly Thr Tyr Asn Val Ser Thr Pro Glu Ala Thr Ser Ser Ser Leu
1320                1325                1330                1335

 gaa aac tca tcc agt gct tct tcg ttg ctc aac taa gaac aggataatcc     4326
 Glu Asn Ser Ser Ser Ala Ser Ser Leu Leu Asn 
                1340                1345

 aacctacgtg acctcccggg gacagtggct gtgcttttaa aaagagatgc ttgcaaagca   4386

 atggggaacg tgttctcggg gcaggtttcc gggagcagat gccaaaaaga ctttttcata   4446

 gagaagaggc tttcttttgt aaagacagaa taaaaataat tgttatgttt ctgtttgttc   4506

 cctccccctc ccccttgtgt gataccacat gtgtatagta tttaagtgaa actcaagccc   4566

 tcaaggccca acttctctgt ctatattgta atatagaatt tcgaagagac attttcactt   4626

 tttacacatt gggcacaaag ataagctttg attaaagtag taagtaaaag gctacctagg   4686

 aaatacttca gtgaattcta agaaggaagg aaggaaggaa ggaaggaaag aagggaggga   4746

 aacagggaga aagggaaaaa gaagaaaaag agaaagatga aaataggaac aaataaagac   4806

 aaacaacatt aagggccata ttgtaagatt tccatgttaa tgatctaata taatcactca   4866

 gtgcaacatt gagaattttt ttttaatggc tcaaaaatgg aaactgaaag caagtcatgg   4926

 ggaatgaata ctttgggcag tatcttcctc atgtcttctt agctaagagg aggaaaaaaa   4986

 ggctgaaaaa atagggagga aattccttca tcagaacgac ttcaagtgga taacaatatt   5046

 tataagaaat gaatggaagg aaatatgatc ctcctgagac taactttgta tgttaaggtt   5106

 tgaactaagt gaatgtatct gcagaggaag tattacaaag atatgtcatt agatccaagt   5166

 gctgattaaa tttttatagt ttatcagaaa agccttatat tttagtttgt tccacatttt   5226

 gaaagcaaaa aatatatatt tgatataccc ttcaattgcc aaatttgata tgttgcactg   5286

 aagacagacc ctgtcatata tttaatggct tcaagcaggt acttctctgt gcattataga   5346

 atagatttta ataatcttat agcattgtat attattattg ctgttgtcac tgttattatt   5406

 attgtggata ctggcccttg gtgtgttgca tagctcccta tgtattctct gtttccatct   5466

 ttaagttccc agaccaatat acattaagag ttttgcatgg tctaaattgt gtttattcca   5526

 accacgtgga aagctcctgg aaagaaattt tacattcggt tgttctgtgc tcctaatgac   5586

 acttgacctt gttgaacaaa tggcagagcc tttcccaagg atttgattgt ttgtgaatta   5646

 tctgcatgtg tgcttttttt tggtgtgtat ttcattaaaa aatataaata tttatgaaaa   5706

 aaaaaaaa                                                            5714




      <210> 76
      <211> 1461
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1317)

      <400> 76
  atg aat aca ttg tca tca aca ggg caa ggc aat aca gaa gtg atc cac      48
  Met Asn Thr Leu Ser Ser Thr Gly Gln Gly Asn Thr Glu Val Ile His
    1               5                  10                  15

 aca ggg aca ttg cag aga caa gca agt tat cac att gga gca ttt tgc       96
 Thr Gly Thr Leu Gln Arg Gln Ala Ser Tyr His Ile Gly Ala Phe Cys
              20                  25                  30

 tcc cag gaa att gag aaa gac att cat gac ttt gtg ttt cag tgg caa      144
 Ser Gln Glu Ile Glu Lys Asp Ile His Asp Phe Val Phe Gln Trp Gln
          35                  40                  45

 gaa gat gaa aca aat gac cat gaa gca ccc atg aca gaa ata aaa aag      192
 Glu Asp Glu Thr Asn Asp His Glu Ala Pro Met Thr Glu Ile Lys Lys
      50                  55                  60

 ttg act agt agt aca gac cga tat gat caa agg cat gct gga aac aag      240
 Leu Thr Ser Ser Thr Asp Arg Tyr Asp Gln Arg His Ala Gly Asn Lys
  65                  70                  75                  80

 cct att aaa ggt cag ctt gaa tca aga ttt cat ttg cat ttg cga aga      288
 Pro Ile Lys Gly Gln Leu Glu Ser Arg Phe His Leu His Leu Arg Arg
                  85                  90                  95

 cat agg aga att cat act gga gag aaa cct tac aaa tgt gaa gaa tgt      336
 His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys
             100                 105                 110

 gag aaa gtt ttc agt tgc aaa tca cat ctt gaa ata cat agg ata att      384
 Glu Lys Val Phe Ser Cys Lys Ser His Leu Glu Ile His Arg Ile Ile
         115                 120                 125

 cat act gga gag aaa cca tac aaa tgt aag gtt tgc gac aag gct ttt      432
 His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Val Cys Asp Lys Ala Phe
     130                 135                 140

 aag cat gat tca cac ctg gca aaa cat act aga att cac agg gga gac      480
 Lys His Asp Ser His Leu Ala Lys His Thr Arg Ile His Arg Gly Asp
 145                 150                 155                 160

 aaa cat tac aca tgt aat gaa tgt ggc aag gtt ttt gat caa aaa gca      528
 Lys His Tyr Thr Cys Asn Glu Cys Gly Lys Val Phe Asp Gln Lys Ala
                 165                 170                 175

 acc ctt gca tgt cat cat aga agt cat act gga gag aaa cct tat aag      576
 Thr Leu Ala Cys His His Arg Ser His Thr Gly Glu Lys Pro Tyr Lys
             180                 185                 190

 tgt aat gag tgt ggc aag acc ttt agt cag aca tca cac ctt gtg tac      624
 Cys Asn Glu Cys Gly Lys Thr Phe Ser Gln Thr Ser His Leu Val Tyr
         195                 200                 205

 cat cat aga ctg cat act gga gag aaa cct tac aaa tgt aat gag tgt      672
 His His Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys
     210                 215                 220

 ggc aag acc ttc gct cga aat tca gtc ctc gta att cat aag gca gtt      720
 Gly Lys Thr Phe Ala Arg Asn Ser Val Leu Val Ile His Lys Ala Val
 225                 230                 235                 240

 cat act gca gag aaa ccc tat aag tgt aat gaa tgt ggc aag gtt ttt      768
 His Thr Ala Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe
                 245                 250                 255

 aag caa cga gca act ctt gca gga cat cgt aga gtt cac act gga gag      816
 Lys Gln Arg Ala Thr Leu Ala Gly His Arg Arg Val His Thr Gly Glu
             260                 265                 270

 aaa cct tac aga tgt gaa gaa tgc gac aaa gtt ttc agt cgc aaa tca      864
 Lys Pro Tyr Arg Cys Glu Glu Cys Asp Lys Val Phe Ser Arg Lys Ser
         275                 280                 285

 cat ctt gaa aga cat agg agg att cat act gga gag aaa cca tac aaa      912
 His Leu Glu Arg His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Lys
     290                 295                 300

 tgt aag gtt tgt gac aag gct ttc cgg agt gat tca cgt ctt gca gaa      960
 Cys Lys Val Cys Asp Lys Ala Phe Arg Ser Asp Ser Arg Leu Ala Glu
 305                 310                 315                 320

 cat cag aga gtt cat act gga gag aga cct tac aca tgt aat gaa tgt     1008
 His Gln Arg Val His Thr Gly Glu Arg Pro Tyr Thr Cys Asn Glu Cys
                 325                 330                 335

 ggc aag gtt ttt agt aca aaa gca tac ctc gca tgt cat caa aaa ctt     1056
 Gly Lys Val Phe Ser Thr Lys Ala Tyr Leu Ala Cys His Gln Lys Leu
             340                 345                 350

 cat act gga gag aaa ctt tac gaa tgt gaa gaa tgt gac aaa gtt tac     1104
 His Thr Gly Glu Lys Leu Tyr Glu Cys Glu Glu Cys Asp Lys Val Tyr
         355                 360                 365

 att cgc aaa tca cac ctt gaa aga cat agg agg att cat aca gga gag     1152
 Ile Arg Lys Ser His Leu Glu Arg His Arg Arg Ile His Thr Gly Glu
     370                 375                 380

 aaa cct cac aag tgt ggt gat tgt ggt aaa gcc ttt aat tca cct tca     1200
 Lys Pro His Lys Cys Gly Asp Cys Gly Lys Ala Phe Asn Ser Pro Ser
 385                 390                 395                 400

 cac ctt att agg cat cag aga atc cat act gga cag aaa tct tac aaa     1248
 His Leu Ile Arg His Gln Arg Ile His Thr Gly Gln Lys Ser Tyr Lys
                 405                 410                 415

 tgt cat cag tgt ggc aag gtc ttc agt ctg aga tca ccc ctt gca gaa     1296
 Cys His Gln Cys Gly Lys Val Phe Ser Leu Arg Ser Pro Leu Ala Glu
             420                 425                 430

 tat cag aaa att cat ttt tga ga tgattgttcc aaatgcaatg agtatagcaa     1349
 Tyr Gln Lys Ile His Phe 
         435

 accatcaagc attaattggc attagagtca attcagcatt gacttgagtt tgaattgact   1409

 taacattgag ttcaagcatt aattgacatt aaagtgttta tgttaagaag at           1461




      <210> 77
      <211> 3442
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (339)..(3359)

      <400> 77
 aaagatatgc tttttttttc ttttttaagg aaaaaatatc ccatggctgt taaggtttct     60

 gttattattt gttttttcta tttttatttg gacagtacag aaaactgtgt ttcaaaatag    120

 ttgatggctt tccatttttc tacctcccag cttatttttt tctagcacaa ttctttatat    180

 gtaaccccag gctgtctaaa ggagagggaa acagtggtaa aacagtgctg tgggcttctg    240

 aagagaattt tgggtgagtc ataaagaggt ttgttttgtt tttttatttt ccagggattg    300

 ttgtctgtga ggtgcctaac aacaagttag ataaattc    atg gga atc ctt tct     353
                                              Met Gly Ile Leu Ser
                                                1               5

 tgg aaa gac agc aag cat tcc ctc aac aat gag aag ata atc ctg aga      401
 Trp Lys Asp Ser Lys His Ser Leu Asn Asn Glu Lys Ile Ile Leu Arg
                  10                  15                  20

 ggc tgc atc ctg aga aat acc agc tgg tgt ttt gga atg gtt att ttt      449
 Gly Cys Ile Leu Arg Asn Thr Ser Trp Cys Phe Gly Met Val Ile Phe
              25                  30                  35

 gca ggt cct gac act aaa cta atg cag aat agt ggt aag aca aag ttt      497
 Ala Gly Pro Asp Thr Lys Leu Met Gln Asn Ser Gly Lys Thr Lys Phe
          40                  45                  50

 aaa agg aca agc att gat aga ttg atg aat act cta gta cta tgg gta      545
 Lys Arg Thr Ser Ile Asp Arg Leu Met Asn Thr Leu Val Leu Trp Val
      55                  60                  65

 att ttt ggg ttt ctg ata tgc ttg gga att att ctt gca ata gga aat      593
 Ile Phe Gly Phe Leu Ile Cys Leu Gly Ile Ile Leu Ala Ile Gly Asn
  70                  75                  80                  85

 tca atc tgg gag agt caa act ggg gac caa ttc aga act ttc ctc ttt      641
 Ser Ile Trp Glu Ser Gln Thr Gly Asp Gln Phe Arg Thr Phe Leu Phe
                  90                  95                 100

 tgg aat gaa gga gag aag agc tct gtg ttc tcc gga ttc tta aca ttc      689
 Trp Asn Glu Gly Glu Lys Ser Ser Val Phe Ser Gly Phe Leu Thr Phe
             105                 110                 115

 tgg tca tat att att att ctc aat aca gtt gta ccc att tcc tta tat      737
 Trp Ser Tyr Ile Ile Ile Leu Asn Thr Val Val Pro Ile Ser Leu Tyr
         120                 125                 130

 gtg agt gtg gaa gta att cgt cta gga cac agt tat ttt ata aac tgg      785
 Val Ser Val Glu Val Ile Arg Leu Gly His Ser Tyr Phe Ile Asn Trp
     135                 140                 145

 gac cgg aag atg tat tat tct cga aaa gca ata cct gca gtg gct cga      833
 Asp Arg Lys Met Tyr Tyr Ser Arg Lys Ala Ile Pro Ala Val Ala Arg
 150                 155                 160                 165

 acg acc acg ctc aat gag gaa ctg ggg cag att gag tac att ttc tcc      881
 Thr Thr Thr Leu Asn Glu Glu Leu Gly Gln Ile Glu Tyr Ile Phe Ser
                 170                 175                 180

 gac aaa acg ggt acc ctc act caa aac atc atg acc ttt aaa aga tgt      929
 Asp Lys Thr Gly Thr Leu Thr Gln Asn Ile Met Thr Phe Lys Arg Cys
             185                 190                 195

 tcc att aat ggg aga atc tat ggt gaa gta cat gat gac ctg gat cag      977
 Ser Ile Asn Gly Arg Ile Tyr Gly Glu Val His Asp Asp Leu Asp Gln
         200                 205                 210

 aag aca gaa ata act cag gaa aaa gag cct gtg gat ttc tca gtc aaa     1025
 Lys Thr Glu Ile Thr Gln Glu Lys Glu Pro Val Asp Phe Ser Val Lys
     215                 220                 225

 tct caa gcg gat aga gaa ttt cag ttc ttt gac cac aat ctg atg gaa     1073
 Ser Gln Ala Asp Arg Glu Phe Gln Phe Phe Asp His Asn Leu Met Glu
 230                 235                 240                 245

 tcc att aaa atg ggt gat ccc aaa gtt cat gaa ttc ctt agg tta ctt     1121
 Ser Ile Lys Met Gly Asp Pro Lys Val His Glu Phe Leu Arg Leu Leu
                 250                 255                 260

 gct ctc tgc cac act gta atg tca gaa gag aat agc gca ggt aag gga     1169
 Ala Leu Cys His Thr Val Met Ser Glu Glu Asn Ser Ala Gly Lys Gly
             265                 270                 275

 gag ctg att tac caa gtt cag tca cct gat gaa ggg gct cta gtg act     1217
 Glu Leu Ile Tyr Gln Val Gln Ser Pro Asp Glu Gly Ala Leu Val Thr
         280                 285                 290

 gcc gct aga aat ttt ggg ttc att ttt aaa tcc cgg acc cca gag acc     1265
 Ala Ala Arg Asn Phe Gly Phe Ile Phe Lys Ser Arg Thr Pro Glu Thr
     295                 300                 305

 ata aca ata gaa gaa ttg gga aca cta gtt act tat caa tta ctt gcc     1313
 Ile Thr Ile Glu Glu Leu Gly Thr Leu Val Thr Tyr Gln Leu Leu Ala
 310                 315                 320                 325

 ttt ttg gat ttc aac aac acc aga aaa agg atg tct gtc ata gtt cga     1361
 Phe Leu Asp Phe Asn Asn Thr Arg Lys Arg Met Ser Val Ile Val Arg
                 330                 335                 340

 aac cca gaa gga cag ata aag ctt tat tcc aaa gga gca gat act att     1409
 Asn Pro Glu Gly Gln Ile Lys Leu Tyr Ser Lys Gly Ala Asp Thr Ile
             345                 350                 355

 ctg ttt gaa aaa ctt cat cct tcc aat gaa gtc ctt ttg tct ttg acg     1457
 Leu Phe Glu Lys Leu His Pro Ser Asn Glu Val Leu Leu Ser Leu Thr
         360                 365                 370

 tca gac cac ctc agt cat ctc tgg cag gaa ttt gca ggg gaa ggc ctt     1505
 Ser Asp His Leu Ser His Leu Trp Gln Glu Phe Ala Gly Glu Gly Leu
     375                 380                 385

 cgg acc ttg gcc atc gca tac aga gac ctg gat gac aag tac ttt aaa     1553
 Arg Thr Leu Ala Ile Ala Tyr Arg Asp Leu Asp Asp Lys Tyr Phe Lys
 390                 395                 400                 405

 gag tgg cat aag atg ctt gaa gat gcg aat gct gcc aca gaa gag agg     1601
 Glu Trp His Lys Met Leu Glu Asp Ala Asn Ala Ala Thr Glu Glu Arg
                 410                 415                 420

 gat gaa cga ata gct ggg cta tat gaa gaa att gaa aga gat ttg atg     1649
 Asp Glu Arg Ile Ala Gly Leu Tyr Glu Glu Ile Glu Arg Asp Leu Met
             425                 430                 435

 cta cta ggt gcc act gct gta gaa gat aag tta cag gag ggt gtt att     1697
 Leu Leu Gly Ala Thr Ala Val Glu Asp Lys Leu Gln Glu Gly Val Ile
         440                 445                 450

 gaa aca gtt aca agt tta tca cta gcc aat att aag atc tgg gtc cta     1745
 Glu Thr Val Thr Ser Leu Ser Leu Ala Asn Ile Lys Ile Trp Val Leu
     455                 460                 465

 aca gga gac aaa caa gaa act gcc atc aac atc ggt tat gcc tgc aac     1793
 Thr Gly Asp Lys Gln Glu Thr Ala Ile Asn Ile Gly Tyr Ala Cys Asn
 470                 475                 480                 485

 atg ctg act gac gac atg aat gat gtg ttt gtg ata gca ggg aat aat     1841
 Met Leu Thr Asp Asp Met Asn Asp Val Phe Val Ile Ala Gly Asn Asn
                 490                 495                 500

 gct gtg gaa gtg aga gaa gaa aga aat ttt tcc aat ggc cat gta gtt     1889
 Ala Val Glu Val Arg Glu Glu Arg Asn Phe Ser Asn Gly His Val Val
             505                 510                 515

 tgt gaa aaa aag cag cag ctg gag ttg gat tct att gta gaa gaa acc     1937
 Cys Glu Lys Lys Gln Gln Leu Glu Leu Asp Ser Ile Val Glu Glu Thr
         520                 525                 530

 ata aca gga gat tat gcc tta atc ata aat ggc cac agt ttg gct cat     1985
 Ile Thr Gly Asp Tyr Ala Leu Ile Ile Asn Gly His Ser Leu Ala His
     535                 540                 545

 gcc cta gaa agt gat gtc aag aat gat ctc cta gaa ctt gct tgc atg     2033
 Ala Leu Glu Ser Asp Val Lys Asn Asp Leu Leu Glu Leu Ala Cys Met
 550                 555                 560                 565

 tgt aag act gta att tgc tgc agg gtc act cca ctc cag aaa gcc caa     2081
 Cys Lys Thr Val Ile Cys Cys Arg Val Thr Pro Leu Gln Lys Ala Gln
                 570                 575                 580

 gtg gta gag ctg gtg aag aag tac aga aat gct gtt act ttg gcc att     2129
 Val Val Glu Leu Val Lys Lys Tyr Arg Asn Ala Val Thr Leu Ala Ile
             585                 590                 595

 ggt gat gga gcc aat gat gtc agc atg att aaa agt aag agg ata cac     2177
 Gly Asp Gly Ala Asn Asp Val Ser Met Ile Lys Ser Lys Arg Ile His
         600                 605                 610

 att ggt gtt ggc atc agc ggc cag gaa gga ttg caa gca gtc tta gcc     2225
 Ile Gly Val Gly Ile Ser Gly Gln Glu Gly Leu Gln Ala Val Leu Ala
     615                 620                 625

 agc gac tat tca ttt gca cag ttt aga tat ctc caa agg ctt ctc ctt     2273
 Ser Asp Tyr Ser Phe Ala Gln Phe Arg Tyr Leu Gln Arg Leu Leu Leu
 630                 635                 640                 645

 gtt cat gga agg tgg tct tat ttc cga atg tgc aaa ttc tta tgc tat     2321
 Val His Gly Arg Trp Ser Tyr Phe Arg Met Cys Lys Phe Leu Cys Tyr
                 650                 655                 660

 ttc ttc tat aag aat ttt gca ttt aca ctt gtg cat ttc tgg ttt ggt     2369
 Phe Phe Tyr Lys Asn Phe Ala Phe Thr Leu Val His Phe Trp Phe Gly
             665                 670                 675

 ttc ttc tgt ggt ttc tca gcc cag gtt gtt tat gac cag tgg ttc atc     2417
 Phe Phe Cys Gly Phe Ser Ala Gln Val Val Tyr Asp Gln Trp Phe Ile
         680                 685                 690

 acc ctt ttt aac att gtt tac aca tca ctg cct gtt tta gcc atg ggg     2465
 Thr Leu Phe Asn Ile Val Tyr Thr Ser Leu Pro Val Leu Ala Met Gly
     695                 700                 705

 att ttt gac cag gat gtg agt gac cag aac agc gtg gac tgt ccc cag     2513
 Ile Phe Asp Gln Asp Val Ser Asp Gln Asn Ser Val Asp Cys Pro Gln
 710                 715                 720                 725

 ctc tac aaa cca gga cag ctg aat ctg ctt ttt aac aag cgt aaa ttt     2561
 Leu Tyr Lys Pro Gly Gln Leu Asn Leu Leu Phe Asn Lys Arg Lys Phe
                 730                 735                 740

 ttc att tgc gtg ttg cat gga atc tac acc tca tta gtc ctt ttc ttc     2609
 Phe Ile Cys Val Leu His Gly Ile Tyr Thr Ser Leu Val Leu Phe Phe
             745                 750                 755

 atc ccc tat ggg gcc ttt tac aac gtg gct gga gaa gat ggg caa cat     2657
 Ile Pro Tyr Gly Ala Phe Tyr Asn Val Ala Gly Glu Asp Gly Gln His
         760                 765                 770

 att gct gac tac cag tcc ttt gca gtt acc atg gcc aca tct ttg gtc     2705
 Ile Ala Asp Tyr Gln Ser Phe Ala Val Thr Met Ala Thr Ser Leu Val
     775                 780                 785

 att gtg gtc agt gtg cag ata gcc ttg gat acc agt tac tgg act ttc     2753
 Ile Val Val Ser Val Gln Ile Ala Leu Asp Thr Ser Tyr Trp Thr Phe
 790                 795                 800                 805

 att aat cac gtc ttc atc tgg ggg agc att gcc att tat ttc tcc att     2801
 Ile Asn His Val Phe Ile Trp Gly Ser Ile Ala Ile Tyr Phe Ser Ile
                 810                 815                 820

 tta ttt aca atg cac agt aat ggc atc ttt ggc atc ttc cca aac cag     2849
 Leu Phe Thr Met His Ser Asn Gly Ile Phe Gly Ile Phe Pro Asn Gln
             825                 830                 835

 ttt ttg ata ggt aat gca cga cat tcc ctg acc cag aag tgc atc tgg     2897
 Phe Leu Ile Gly Asn Ala Arg His Ser Leu Thr Gln Lys Cys Ile Trp
         840                 845                 850

 ctt gta att ctc tta aca aca gtg gct tca gtt atg cca gtg gtg gca     2945
 Leu Val Ile Leu Leu Thr Thr Val Ala Ser Val Met Pro Val Val Ala
     855                 860                 865

 ttc aga ttt ttg aag gtg gat tta tac cca acc ctg agt gat cag gta     2993
 Phe Arg Phe Leu Lys Val Asp Leu Tyr Pro Thr Leu Ser Asp Gln Val
 870                 875                 880                 885

 atc cgc cgg tgg cag aag gct caa aag aag gca agg cct cca agt agc     3041
 Ile Arg Arg Trp Gln Lys Ala Gln Lys Lys Ala Arg Pro Pro Ser Ser
                 890                 895                 900

 cga agg cct cgg acc cgc agg tca agc tca aga agg tct ggc tat gct     3089
 Arg Arg Pro Arg Thr Arg Arg Ser Ser Ser Arg Arg Ser Gly Tyr Ala
             905                 910                 915

 ttt gct cac caa gaa ggc tat gga gag ctt atc aca tct gga aaa aat     3137
 Phe Ala His Gln Glu Gly Tyr Gly Glu Leu Ile Thr Ser Gly Lys Asn
         920                 925                 930

 atg cga gct aaa aat cca ccc cca aca tca ggg ctg gaa aag aca cat     3185
 Met Arg Ala Lys Asn Pro Pro Pro Thr Ser Gly Leu Glu Lys Thr His
     935                 940                 945

 tat aat agc act agc tgg att gaa aat tta tgt aag aaa acc aca gac     3233
 Tyr Asn Ser Thr Ser Trp Ile Glu Asn Leu Cys Lys Lys Thr Thr Asp
 950                 955                 960                 965

 acc gtg agc agc ttt agc cag gat aaa aca gtg aaa act gtg agt caa     3281
 Thr Val Ser Ser Phe Ser Gln Asp Lys Thr Val Lys Thr Val Ser Gln
                 970                 975                 980

 tat gaa ttt aaa cca cgt agt tat ctt ttc act tca ggt gga gct gaa     3329
 Tyr Glu Phe Lys Pro Arg Ser Tyr Leu Phe Thr Ser Gly Gly Ala Glu
             985                 990                 995

 att ctg ctg gct cca gag ttt gag att tga g gcaagaggtg gggcaggcag     3380
 Ile Leu Leu Ala Pro Glu Phe Glu Ile 
        1000                1005

 attgcctcac ttaacttaaa tctgcggcag acaactgcca gtgcccatca aacaggagtg   3440

 tg                                                                  3442




      <210> 78
      <211> 1505
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (324)..(1016)

      <220>
      <221> misc_feature
      <222> (1)...(1505)
      <223> n = a,t,c or g

      <400> 78
 ctccactcca ctccactcca ctccactcca ctccactcca ctccactcca ctccagtttg     60

 gacgaggcct tagaggcatc agcgtatcac tttcctcgta agtcgggagt gatggaacga    120

 ccaccctgta gtgcggttgt gagaattgag atgaggcttg gctcatattg agtgctcagc    180

 tttcctggct tatagacagt ggaggggcgt ggccccacca tgcaccccaa gggtctcaga    240

 ctcaagggcc agcaggagga gttggcgggg agccttgggc ccctctggcc tcagccggat    300

 ttcccagcca aacgcagaga gag    atg ccc tgg acc atc ttg ctc ttt gca     350
                              Met Pro Trp Thr Ile Leu Leu Phe Ala
                                1               5

 gct ggc tcc ttg gcg atc cca gca cca tcc atc cgg ctg gtg ccc ccg      398
 Ala Gly Ser Leu Ala Ile Pro Ala Pro Ser Ile Arg Leu Val Pro Pro
  10                  15                  20                  25

 tac cca agc agc caa gag gac ccc atc cac atc gca tgc atg gcc cct      446
 Tyr Pro Ser Ser Gln Glu Asp Pro Ile His Ile Ala Cys Met Ala Pro
                  30                  35                  40

 ggg aac ttc ccg ggg gcg aat ttc aca ctg tat cga ggg ggg cag gtg      494
 Gly Asn Phe Pro Gly Ala Asn Phe Thr Leu Tyr Arg Gly Gly Gln Val
              45                  50                  55

 gtc cag ctc ctg cag gcc ccc acg gac cag cgc ggg gtg aca ttt aac      542
 Val Gln Leu Leu Gln Ala Pro Thr Asp Gln Arg Gly Val Thr Phe Asn
          60                  65                  70

 ctg agc ggc ggc agc agc aag gct cca ggg gga ccc ttc cac tgc cag      590
 Leu Ser Gly Gly Ser Ser Lys Ala Pro Gly Gly Pro Phe His Cys Gln
      75                  80                  85

 tat gga gtg tta ggt gag ctc aac cag tcc cag ctg tca gac ctc agc      638
 Tyr Gly Val Leu Gly Glu Leu Asn Gln Ser Gln Leu Ser Asp Leu Ser
  90                  95                 100                 105

 gag ccc gtg aac gtc tcc ttc cca gtg ccc act tgg atc ttg gtg ctc      686
 Glu Pro Val Asn Val Ser Phe Pro Val Pro Thr Trp Ile Leu Val Leu
                 110                 115                 120

 tcc ctg agc ctg gct ggt gcc ctc ttc ctc ctt gct ggg ctg gtg gct      734
 Ser Leu Ser Leu Ala Gly Ala Leu Phe Leu Leu Ala Gly Leu Val Ala
             125                 130                 135

 gtt gcc ctg gtg gtc aga aaa gtt aaa ctc aga aat tta cag aag aaa      782
 Val Ala Leu Val Val Arg Lys Val Lys Leu Arg Asn Leu Gln Lys Lys
         140                 145                 150

 aga gat cga gaa tcc tgc tgg gcc cag att aac ttc gac agc aca gac      830
 Arg Asp Arg Glu Ser Cys Trp Ala Gln Ile Asn Phe Asp Ser Thr Asp
     155                 160                 165

 atg tcc ttc gat aac tcc ctg ttt acc gtc tcc gcg aaa acg atg cca      878
 Met Ser Phe Asp Asn Ser Leu Phe Thr Val Ser Ala Lys Thr Met Pro
 170                 175                 180                 185

 gaa gaa gac ccg gcc acc ttg gat gat cac tca ggc acc act gcc acc      926
 Glu Glu Asp Pro Ala Thr Leu Asp Asp His Ser Gly Thr Thr Ala Thr
                 190                 195                 200

 ccc agc aac tcc agg acc cgg aag agg ccc act tcc acg tcc tcc tcg      974
 Pro Ser Asn Ser Arg Thr Arg Lys Arg Pro Thr Ser Thr Ser Ser Ser
             205                 210                 215

 cct gag acc ccc gaa ttc agc act ttc cgg gcc tgc cag tga ggctgag     1023
 Pro Glu Thr Pro Glu Phe Ser Thr Phe Arg Ala Cys Gln 
         220                 225                 230

 gactggggga cccctctgtc tccaggcatt cgggggcctg aggtccctcc agctacttct   1083

 gggggggctc tgtcagccac tttctcaggg aattggacag aggaaaggaa ggggaaccct   1143

 ggccttggga ttttcatcac agaggagtgg gagaggggac acaggcatgg gcctggcact   1203

 atacagacaa caggaagttc ccctctcgac cttcggctcc tcaggaccac cagagaagga   1263

 gatgtcagga ccccttcttg tcccccagct gggccataag acgtcccagg tctctgcaca   1323

 cccgtggaat tcctcccttc cccagtgggt ttttgagcat agggtgccct tgggtgtgtt   1383

 gtgtgtctgc ctgctggctt gcttaagtta ttaatctcag aacaacgaca gcggccgctc   1443

 tagaggatcc aagcttacgt acgcgtgcat gcccatgaac ttaatngnan gagcgggggg   1503

 cg                                                                  1505




      <210> 79
      <211> 1447
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (298)..(1029)

      <400> 79
 ctccagtgca agctaaaatt accctcacta aagggaataa gcttgcggcc gcaccaattt     60

 tttttttttt tttttttttt tttttgctta aaaaaaagcc atgacggctc tcccacaatt    120

 catcttccct gcgccatctt tgtattattt ctaatttatt ttggatgtca aaaggcactg    180

 atgaagatat tttctctgga gtctccttct ttctaacccg gctctcccga tgtgaaccga    240

 gccgtcgtcc gcccgccgcc gccgccgccg ccgccgccgc ccgccccgca gcccacc       297                                                                 
 atg tct cgc cgc aag caa ggc aaa ccc cag cac tta agc aaa cgg gaa      345
 Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu
   1               5                  10                  15

 ttc tcg ccc gag cct ctt gaa gcc att ctt aca gat gat gaa cca gac      393
 Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp
              20                  25                  30

 cac ggc ccg ttg gga gct cca gaa ggg gat cat gac ctc ctc acc tgt      441
 His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys
          35                  40                  45

 ggg cag tgc cag atg aac ttc cca ttg ggg gac att ctt att ttt atc      489
 Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile
      50                  55                  60

 gag cac aaa cgg aaa caa tgc aat ggc agc ctc tgc tta gaa aaa gct      537
 Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala
  65                  70                  75                  80

 gtg gat aag cca cct tcc cct tca cca atc gag atg aaa aaa gca tcc      585
 Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser
                  85                  90                  95

 aat ccc gtg gag gtt ggc atc cag gtc acg cca gag gat gac gat tgt      633
 Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys
             100                 105                 110

 tta tca acg tca tct aga gga att tgc ccc aaa cag gaa cac ata gca      681
 Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala
         115                 120                 125

 gat aaa ctt ctg cac tgg agg ggc ctc tcc tcc cct cgt tct gca cat      729
 Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His
     130                 135                 140

 gga gct cta atc ccc acg cct ggg atg agt gca gaa tat gcc ccg cag      777
 Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln
 145                 150                 155                 160

 ggt att tgt aaa gat gag ccc agc agc tac aca tgt aca act tgc aaa      825
 Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys
                 165                 170                 175

 cag cca ttc acc agt gca tgg ttt ctc ttg caa cac gca cag aac act      873
 Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr
             180                 185                 190

 cat gga tta aga atc tac tta gaa agc gaa cac gga agt ccc ctg acc      921
 His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr
         195                 200                 205

 ccg cgg gtt ctt cac aca ccc cca ttc ggc gta gta ccc aga gag ctc      969
 Pro Arg Val Leu His Thr Pro Pro Phe Gly Val Val Pro Arg Glu Leu
     210                 215                 220

 aag atg tgt ggc agt ttt cgg atg gaa gct cga gag ccc tta agt tct     1017
 Lys Met Cys Gly Ser Phe Arg Met Glu Ala Arg Glu Pro Leu Ser Ser
 225                 230                 235                 240

 gag aaa att tga agc ccccaggggt ggggtggacg cgtgccgccc agtcgacgtc     1072
 Glu Lys Ile 


 agcgtggtct gtcatcctgc tagtttgtga tgttttctga cagtagcctc caagaagccg   1132

 ttgtgcgaag acagagtcct gcagagtcct tccagcctag gcctgcagcg ccattttatt   1192

 tatatttttt aataaaaagt aaaaacaaaa aaacagaccc acattggaac agtgaatcag   1252

 tcccatagag agggcccgtg gaccatcgct gtcatgagtg atgccctggc ccttctgaaa   1312

 ccagccaacc taattacctg tattgtggaa atgcgcatga gtccccaacc ccttgtttct   1372

 atacattcta tgttgtcttt taaaaagtgt gcttaacatt gacacaataa atgttggagc   1432

 tttaaaaaaa aaaaa                                                    1447




      <210> 80
      <211> 2108
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(1212)

      <400> 80
 cggacgcgtg ggcggacgcg tggggtgagg cacagatgag taacgtgaat ttgtccgtct     60

 ccgacttctg gagatttatt ttttttagat gaggtgttgc tgtgttgccc aagctggact    120

 tgaaccccta ggctcaagca atccttccac ctcagtctcc caagtagcag ggactacaga    180

 gtg  atg atg cgg gtg tgc tgg ttg gtg aga cag gac agc cgg cac cag     228
      Met Met Arg Val Cys Trp Leu Val Arg Gln Asp Ser Arg His Gln
        1               5                  10                  15

 cga atc aga ctt cca cat ttg gaa gca gtt gtg att ggg cgt ggc cca      276
 Arg Ile Arg Leu Pro His Leu Glu Ala Val Val Ile Gly Arg Gly Pro
                  20                  25                  30

 gag acc aag atc act gat aag aaa tgt tct cga cag caa gta cag ttg      324
 Glu Thr Lys Ile Thr Asp Lys Lys Cys Ser Arg Gln Gln Val Gln Leu
              35                  40                  45

 aaa gca gag tgt aac aag gga tat gtc aag gta aag cag gta gga gtc      372
 Lys Ala Glu Cys Asn Lys Gly Tyr Val Lys Val Lys Gln Val Gly Val
          50                  55                  60

 aat ccc acc agc att gac tca gtc gta att ggg aag gac caa gag gtg      420
 Asn Pro Thr Ser Ile Asp Ser Val Val Ile Gly Lys Asp Gln Glu Val
      65                  70                  75

 aag ctg cag cct ggc cag gtt ctc cac atg gtg aat gaa ctt tat cca      468
 Lys Leu Gln Pro Gly Gln Val Leu His Met Val Asn Glu Leu Tyr Pro
  80                  85                  90                  95

 tat att gta gag ttt gag gaa gag gca aag aac cct ggc ctg gaa aca      516
 Tyr Ile Val Glu Phe Glu Glu Glu Ala Lys Asn Pro Gly Leu Glu Thr
                 100                 105                 110

 cac agg aag aga aag aga tca ggc aac agt gat tct ata gaa agg gat      564
 His Arg Lys Arg Lys Arg Ser Gly Asn Ser Asp Ser Ile Glu Arg Asp
             115                 120                 125

 gct gct cag gaa gct gag gct ggg aca ggg ctg gaa cct ggg agc aac      612
 Ala Ala Gln Glu Ala Glu Ala Gly Thr Gly Leu Glu Pro Gly Ser Asn
         130                 135                 140

 tct ggc caa tgc tct gtg ccc cta aag aag gga aaa gat gca cct atc      660
 Ser Gly Gln Cys Ser Val Pro Leu Lys Lys Gly Lys Asp Ala Pro Ile
     145                 150                 155

 aaa aag gaa tcc ctg ggc cac tgg agt caa ggc ttg aag att tct atg      708
 Lys Lys Glu Ser Leu Gly His Trp Ser Gln Gly Leu Lys Ile Ser Met
 160                 165                 170                 175

 cag gac ccc aaa atg cag gtt tac aaa gat gag cag gtg gtg gtg ata      756
 Gln Asp Pro Lys Met Gln Val Tyr Lys Asp Glu Gln Val Val Val Ile
                 180                 185                 190

 aag gat aaa tac cca aag gcc cgt tac cat tgg ctg gtc tta ccg tgg      804
 Lys Asp Lys Tyr Pro Lys Ala Arg Tyr His Trp Leu Val Leu Pro Trp
             195                 200                 205

 acc tcc att tcc agt ctg aag gct gtg gcc agg gaa cac ctt gaa ctc      852
 Thr Ser Ile Ser Ser Leu Lys Ala Val Ala Arg Glu His Leu Glu Leu
         210                 215                 220

 ctt aag cat atg cac act gtg ggg gaa aag gtg att gta gat ttt gct      900
 Leu Lys His Met His Thr Val Gly Glu Lys Val Ile Val Asp Phe Ala
     225                 230                 235

 ggg tcc agc aaa ctc cgc ttc cga ttg ggc tac cac gcc att ccg agt      948
 Gly Ser Ser Lys Leu Arg Phe Arg Leu Gly Tyr His Ala Ile Pro Ser
 240                 245                 250                 255

 atg agc cat gta cat ctt cat gtg atc agc cag gat ttt gat tct cct      996
 Met Ser His Val His Leu His Val Ile Ser Gln Asp Phe Asp Ser Pro
                 260                 265                 270

 tgc ctt aaa aac aaa aaa cat tgg aat tct ttc aat aca gaa tac ttc     1044
 Cys Leu Lys Asn Lys Lys His Trp Asn Ser Phe Asn Thr Glu Tyr Phe
             275                 280                 285

 cta gaa tca caa gct gtg atc gag atg gta caa gag gct ggt aga gta     1092
 Leu Glu Ser Gln Ala Val Ile Glu Met Val Gln Glu Ala Gly Arg Val
         290                 295                 300

 act gtc cga gat ggg atg cct gag ctc ttg aag ctg ccc ctt cgt tgt     1140
 Thr Val Arg Asp Gly Met Pro Glu Leu Leu Lys Leu Pro Leu Arg Cys
     305                 310                 315

 cat gag tgc cag cag ctg ctg cct tcc att cct cag ctg aaa gaa cat     1188
 His Glu Cys Gln Gln Leu Leu Pro Ser Ile Pro Gln Leu Lys Glu His
 320                 325                 330                 335

 ctc agg aag cac tgg aca cag tga ttctgcagag cctgagctgc tgctgtggtg    1242
 Leu Arg Lys His Trp Thr Gln 
                 340

 tggcccactg gagcaaactg ctggcaccta ttctgggttg cttgtgaact tctactcatt   1302

 tcctaaatta aaacatgcag ctttttcaca aatttattct attattgagt ggccacaatg   1362

 tagagtggct caaagtactt caggattagg aatttgggtt tgtcatagat gtattctctg   1422

 gtgagggtgg ctgggatata cctgacccac catcttcaga aggacccatg tcaggtctga   1482

 ccattgggag caaagccatg ttcacactga cctaatgcag agtatggaag cattgggctg   1542

 gttatacatt tctgtttctt agatttatcc tccgcctctg taggcatgga caacctttaa   1602

 tcagagcatc tagagtggcc tcttgtttat cctgaagata ctgatgggtc ttgttttctg   1662

 ttagtctgtt ttgtaatatt cttttccctt ccttcatggg gaggcttagt ttgtccagtc   1722

 cttccatgcc cttctatccc agattaccta aatgttccct tctcaggaat tctgtctcat   1782

 cagttcttca cagtgagaaa agaggctaga tgatggtgtg gggggttgga gttttcttct   1842

 aataccgagg gttcctggct gtgaggaaac agccacatgt tcgtcatgat tgagctgtga   1902

 agtcttcttg gacctgttgt ctgaaaataa agttaatttg tttgaggcat ctctcttaag   1962

 taggtggaaa ctattgaagt tcagctaaca atcacagcat aggttctgat gcatggaaag   2022

 gtggttggtg aatgaaaaag ttgcgtagag ccactacttt ctttttccct gagaataaat   2082

 ttggataaaa caaaaaaaaa aaaaaa                                        2108




      <210> 81
      <211> 519
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(264)

      <400> 81
 gctatgcgcg gcttcccggc gctcgtggaa tcttctggag cccttttctc cactcagcga     60

 gcctgagagt gcggaagtct ccggctggtg gggcatggcc caggagcact agtg  atg     117
                                                              Met
                                                                1

 atg cgg gtg tgc tgg ttg gtg aga cag gac agc cgg cac cag cga atc      165
 Met Arg Val Cys Trp Leu Val Arg Gln Asp Ser Arg His Gln Arg Ile
               5                  10                  15

 aga ctt cca cat ttg gaa gca gtt gtg att ggg cgt ggc cca gag acc      213
 Arg Leu Pro His Leu Glu Ala Val Val Ile Gly Arg Gly Pro Glu Thr
          20                  25                  30

 aag atc act gat aag aaa tgt tct cga cag caa gtt gaa agc aga gtg      261
 Lys Ile Thr Asp Lys Lys Cys Ser Arg Gln Gln Val Glu Ser Arg Val
      35                  40                  45

 taa caag ggatatgtca aggtaaagca gagtttgagg aagaggcaaa gaaccctggc      318
 


 ctggaaacac acaggaagag aaagagatca ggcaacagtg attctataga aagggatgct    378

 gctcaggaag ctgaggctgg gacagggctg gaacctggga gcaactctgg ccaatgctct    438

 gtgcccctaa agaagggaaa agatgcacct atcaaaaagg aatccctggg ccactggagt    498

 caaggcttga agatttctat g                                              519




      <210> 82
      <211> 524
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(372)

      <400> 82
 gctatgcgcg gcttcccggc gctcgtggaa tcttctggag cccttttctc cactcagcga     60

 gcctgagagt gcggaagtct ccggctggtg gggcatggcc caggagcact agtg  atg     117
                                                              Met
                                                                1

 atg cgg gtg tgc tgg ttg gtg aga cag gac agc cgg cac cag cga atc      165
 Met Arg Val Cys Trp Leu Val Arg Gln Asp Ser Arg His Gln Arg Ile
               5                  10                  15

 aga ctt cca cat ttg gaa gca gtt gtg att ggg cgt ggc cca gag acc      213
 Arg Leu Pro His Leu Glu Ala Val Val Ile Gly Arg Gly Pro Glu Thr
          20                  25                  30

 aag atc act gat aag aaa tgt tct cga cag caa gta cag ttg aaa gca      261
 Lys Ile Thr Asp Lys Lys Cys Ser Arg Gln Gln Val Gln Leu Lys Ala
      35                  40                  45

 gag tgt aac aag gga tat gtc aag gta aag cag agt ttg agg aag agg      309
 Glu Cys Asn Lys Gly Tyr Val Lys Val Lys Gln Ser Leu Arg Lys Arg
  50                  55                  60                  65

 caa aga acc ctg gcc tgg aaa cac aca gga aga gaa aga gat cag gca      357
 Gln Arg Thr Leu Ala Trp Lys His Thr Gly Arg Glu Arg Asp Gln Ala
                  70                  75                  80

 aca gtg att cta tag aaagggatgc tgctcaggaa gctgaggctg ggacagggct      412
 Thr Val Ile Leu 
              85

 ggaacctggg agcaactctg gccaatgctc tgtgccccta aagaagggaa aagatgcacc    472

 tatcaaaaag gaatccctgg gccactggag tcaaggcttg aagatttcta tg            524




      <210> 83
      <211> 1062
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (319)..(1008)

      <220>
      <221> misc_feature
      <222> (1)...(1062)
      <223> n = a,t,c or g

      <400> 83
 agggcnnnta ctgtttcact actcagtgtg gtggaattcg cgtctgtatg atcttcggag     60

 cctgctgcat cggacctcgg ccagtgtgag cggcaagagg ataggagatt atctttctta    120

 tcgcgatggg acgggaaagg gcagttgggg tcggagtcgg cggcagagtg cagagcgcgg    180

 gcggtggagg ccctggagca gcgggctagg ggcggaaccg agtgcctgtc aggcgcgtct    240

 ggagctcttg ggcccgccga ggagatcgca gcgtacaggc agctcgccta ctgcgtaaag    300

 cgaaccccag cataaaag  atg aca aca gca gcc agg cca acc ttt gaa cct     351
                      Met Thr Thr Ala Ala Arg Pro Thr Phe Glu Pro
                        1               5                  10

 gcc aga ggt gga agg gga aaa gga gaa ggt gat ttg agc caa ctt tca      399
 Ala Arg Gly Gly Arg Gly Lys Gly Glu Gly Asp Leu Ser Gln Leu Ser
              15                  20                  25

 aag cag tat tca agc aga gac cta ccc tct cat aca aag ata aaa tac      447
 Lys Gln Tyr Ser Ser Arg Asp Leu Pro Ser His Thr Lys Ile Lys Tyr
          30                  35                  40

 aga cag act act cag gat gcc cct gaa gag gtt cgt aac cgt gac ttc      495
 Arg Gln Thr Thr Gln Asp Ala Pro Glu Glu Val Arg Asn Arg Asp Phe
      45                  50                  55

 agg aga gag ttg gaa gaa aga gag aga gct gct gca aga gag aaa aat      543
 Arg Arg Glu Leu Glu Glu Arg Glu Arg Ala Ala Ala Arg Glu Lys Asn
  60                  65                  70                  75

 agg gat cgt cca acc cga gaa cat aca acc tcc tct tca gtg tca aaa      591
 Arg Asp Arg Pro Thr Arg Glu His Thr Thr Ser Ser Ser Val Ser Lys
                  80                  85                  90

 aag cca cgg tta gac cag att cct gcc gcc aac ctt gat gca gat gac      639
 Lys Pro Arg Leu Asp Gln Ile Pro Ala Ala Asn Leu Asp Ala Asp Asp
              95                 100                 105

 cct cta aca gat gag gaa gat gaa gat ttt gaa gaa gaa agt gat gat      687
 Pro Leu Thr Asp Glu Glu Asp Glu Asp Phe Glu Glu Glu Ser Asp Asp
         110                 115                 120

 gat gat act gca gct ctt ctt gca gaa ctg gaa aaa att aaa aaa gaa      735
 Asp Asp Thr Ala Ala Leu Leu Ala Glu Leu Glu Lys Ile Lys Lys Glu
     125                 130                 135

 aga gct gaa gag cag gcc agg aag gaa caa gaa caa aaa gct gaa gaa      783
 Arg Ala Glu Glu Gln Ala Arg Lys Glu Gln Glu Gln Lys Ala Glu Glu
 140                 145                 150                 155

 gag agg att cgt atg gaa aac att ctg agc gga aac cct ctc ctt aat      831
 Glu Arg Ile Arg Met Glu Asn Ile Leu Ser Gly Asn Pro Leu Leu Asn
                 160                 165                 170

 ctc act ggc cca tcc cag cct cag gcc aac ttc aaa gtt aaa aga agg      879
 Leu Thr Gly Pro Ser Gln Pro Gln Ala Asn Phe Lys Val Lys Arg Arg
             175                 180                 185

 tgg gat gat gac gtt gtc ttc aag aac tgt gca aaa ggt gta gat gac      927
 Trp Asp Asp Asp Val Val Phe Lys Asn Cys Ala Lys Gly Val Asp Asp
         190                 195                 200

 cag aag aaa gac aaa aga ttt gta aat gac aca ctg cga tct gaa ttt      975
 Gln Lys Lys Asp Lys Arg Phe Val Asn Asp Thr Leu Arg Ser Glu Phe
     205                 210                 215

 cac aaa aag ttc atg gag aaa tat att aaa tag tacagttt tatgtgctta     1026
 His Lys Lys Phe Met Glu Lys Tyr Ile Lys 
 220                 225

 attaaagact gtaaaacgta aaggatcaaa aaaaaa                             1062




      <210> 84
      <211> 1078
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2)..(1078)

      <400> 84
 g    agc gcc cac aac agc cac gtg gtc tgc ggg atg act ggg ctt ccc      46
      Ser Ala His Asn Ser His Val Val Cys Gly Met Thr Gly Leu Pro
        1               5                  10                  15

 cag cga aaa gag ggt caa cgc ggc ctt cta cag gcc cgt gtc cgt cta       94
 Gln Arg Lys Glu Gly Gln Arg Gly Leu Leu Gln Ala Arg Val Arg Leu
                  20                  25                  30

 aag ggc ggc gcc cac cct gga gag ggc cgg gta gaa gtc ctg aag gcc      142
 Lys Gly Gly Ala His Pro Gly Glu Gly Arg Val Glu Val Leu Lys Ala
              35                  40                  45

 agc aca tgg ggc aca gtc tgt gac cgc aag tgg gac ctg cat gca gcc      190
 Ser Thr Trp Gly Thr Val Cys Asp Arg Lys Trp Asp Leu His Ala Ala
          50                  55                  60

 agc gtg gtg tgt cgg gag ctg ggc ttc ggg agt gct cga gaa gct ctg      238
 Ser Val Val Cys Arg Glu Leu Gly Phe Gly Ser Ala Arg Glu Ala Leu
      65                  70                  75

 agt ggc gct cgc atg ggg cag ggc atg ggt gct atc cac ctg agt gaa      286
 Ser Gly Ala Arg Met Gly Gln Gly Met Gly Ala Ile His Leu Ser Glu
  80                  85                  90                  95

 gtt cgc tgc tct gga cag gag ctc tcc ctc tgg aag tgc ccc cac aag      334
 Val Arg Cys Ser Gly Gln Glu Leu Ser Leu Trp Lys Cys Pro His Lys
                 100                 105                 110

 aac atc aca gct gag gat tgt tca cat agc cag gat gcc ggg gtc cgg      382
 Asn Ile Thr Ala Glu Asp Cys Ser His Ser Gln Asp Ala Gly Val Arg
             115                 120                 125

 tgc aac cta cct tac act ggg gca gag acc agg atc cga ctc agt ggg      430
 Cys Asn Leu Pro Tyr Thr Gly Ala Glu Thr Arg Ile Arg Leu Ser Gly
         130                 135                 140

 ggc cgc agc caa cat gag ggg cga gtc gag gtg caa ata ggg gga cct      478
 Gly Arg Ser Gln His Glu Gly Arg Val Glu Val Gln Ile Gly Gly Pro
     145                 150                 155

 ggg ccc ctt cgc tgg ggc ctc atc tgt ggg gat gac tgg ggg acc ctg      526
 Gly Pro Leu Arg Trp Gly Leu Ile Cys Gly Asp Asp Trp Gly Thr Leu
 160                 165                 170                 175

 gag gcc atg gtg gcc tgt agg caa ctg ggt ctg ggc tac gcc aac cac      574
 Glu Ala Met Val Ala Cys Arg Gln Leu Gly Leu Gly Tyr Ala Asn His
                 180                 185                 190

 ggc ctg cag gag acc tgg tac tgg gac tct ggg aat ata aca gag gtg      622
 Gly Leu Gln Glu Thr Trp Tyr Trp Asp Ser Gly Asn Ile Thr Glu Val
             195                 200                 205

 gtg atg agt gga gtg cgc tgc aca ggg act gag ctg tcc ctg gat cag      670
 Val Met Ser Gly Val Arg Cys Thr Gly Thr Glu Leu Ser Leu Asp Gln
         210                 215                 220

 tgt gcc cat cat ggc acc cac atc acc tgc aag agg aca ggg acc cgc      718
 Cys Ala His His Gly Thr His Ile Thr Cys Lys Arg Thr Gly Thr Arg
     225                 230                 235

 ttc act gct gga gtc atc tgt tct gag act gca tca gat ctg ttg ctg      766
 Phe Thr Ala Gly Val Ile Cys Ser Glu Thr Ala Ser Asp Leu Leu Leu
 240                 245                 250                 255

 cac tca gca ctg gtg cag gag acc gcc tac atc gaa gac cgg ccc ctg      814
 His Ser Ala Leu Val Gln Glu Thr Ala Tyr Ile Glu Asp Arg Pro Leu
                 260                 265                 270

 cat atg ttg tac tgt gct gcg gaa gag aac tgc ctg gcc agc tca gcc      862
 His Met Leu Tyr Cys Ala Ala Glu Glu Asn Cys Leu Ala Ser Ser Ala
             275                 280                 285

 cgc tca gcc aac tgg ccc tat ggt cac cgg cgt ctg ctc cga ttc tgc      910
 Arg Ser Ala Asn Trp Pro Tyr Gly His Arg Arg Leu Leu Arg Phe Cys
         290                 295                 300

 tcc cag atc cac aac ctg gga cga gct gac ttc agg ccc aag gct ggg      958
 Ser Gln Ile His Asn Leu Gly Arg Ala Asp Phe Arg Pro Lys Ala Gly
     305                 310                 315

 cgc cac tcc tgg gtg tgg cac gag tgc cat ggg cat tac cac agc acg     1006
 Arg His Ser Trp Val Trp His Glu Cys His Gly His Tyr His Ser Thr
 320                 325                 330                 335

 gac ttc ttc act cac tat gat atc ctc acc cca cac ggc acc aag gtg     1054
 Asp Phe Phe Thr His Tyr Asp Ile Leu Thr Pro His Gly Thr Lys Val
                 340                 345                 350

 gct gag ggc cac aaa gct agt ttc                                     1078
 Ala Glu Gly His Lys Ala Ser Phe 
             355





      <210> 85
      <211> 2897
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (825)..(2636)

      <400> 85
 gaggtgaggg aggcggctcg gcgcgagccg cacaacccgg ccgtcgggcc ccgccgccca     60

 gggctgagtc tcccatctcg cccctcggtc cgcagggcct gcgatggagc ctgcagcccc    120

 gggtcgcgtc cctccctgag cgcccccgtc ggcggccatg ctgccccgag ggcgcccccg    180

 ggtcgctggg ggccgccgcg ctgttgctgc tgctgctgct gctcggattc ctcctgttcg    240

 gtggggacct ggggtgtgag cgccgcgagc ctggcgggcg agcgggggcc ccgggatgct    300

 tccccggccc gctcatgcca cgtgtccccc cagacgggag gctgcggaga gccgccgccc    360

 tcgacggaga cccgggggcc ggccccgggg accacaaccg ctccgactgc ggcccgcagc    420

 cgccgccgcc gcccaagtgc gaggtaggtg cgcgcggccc tggcggcggg agtcctgggg    480

 gcgccgcccc cgagcccggc ctcttggaca tctgcgggaa tcacagtacc tggcgtctgt    540

 ccagcactgg ccagccggct ggggcgcacc tcgaacgtgc agctcctctg ctcccgacct    600

 catttcccca tttgaaatga agggttggct cctgctgccc cctccgcaca ctgttccggg    660

 ctctgctgcg gggtggggca gctcaacatg ggtcctcacc gcctagcgga gcacgggggg    720

 gcctggctgt ccgaccctgg ggcgtccctc cccagctctt gcatgtggcc atcgtgtgtg    780

 cggggcataa ctccagccga gacgtcatca ccctggtgaa gtcc atg ctc ttc tac     836
                                                  Met Leu Phe Tyr
                                                    1

 agg aaa aat cca ctg cac ctc cac ttg gtg act gac gcc gtg gcc aga      884
 Arg Lys Asn Pro Leu His Leu His Leu Val Thr Asp Ala Val Ala Arg
   5                  10                  15                  20

 aac atc ctg gag acg ctc ttc cac aca tgg atg gtg cct gct gtc cgt      932
 Asn Ile Leu Glu Thr Leu Phe His Thr Trp Met Val Pro Ala Val Arg
                  25                  30                  35

 gtc agc ttt tat cat gcc gac cag ctc aag ccc cag gtc tcc tgg atc      980
 Val Ser Phe Tyr His Ala Asp Gln Leu Lys Pro Gln Val Ser Trp Ile
              40                  45                  50

 ccc aac aag cac tac tcc ggc ctc tat ggg cta atg aag ctg gtg ctg     1028
 Pro Asn Lys His Tyr Ser Gly Leu Tyr Gly Leu Met Lys Leu Val Leu
          55                  60                  65

 ccc agt gcc ttg cct gct gag ctg gcc cgc gtc att gtc ctg gac acg     1076
 Pro Ser Ala Leu Pro Ala Glu Leu Ala Arg Val Ile Val Leu Asp Thr
      70                  75                  80

 gat gtc acc ttc gcc tct gac atc tcg gag ctc tgg gcc ctc ttt gct     1124
 Asp Val Thr Phe Ala Ser Asp Ile Ser Glu Leu Trp Ala Leu Phe Ala
  85                  90                  95                 100

 cac ttt tct gac acg cag gcg atc ggt ctt gtg gag aac cag agt gac     1172
 His Phe Ser Asp Thr Gln Ala Ile Gly Leu Val Glu Asn Gln Ser Asp
                 105                 110                 115

 tgg tac ctg ggc aac ctc tgg aag aac cac agg ccc tgg cct gcc ttg     1220
 Trp Tyr Leu Gly Asn Leu Trp Lys Asn His Arg Pro Trp Pro Ala Leu
             120                 125                 130

 ggc cgg gga ttt aac aca ggt gtg atc ctg ctg cgg ctg gac cgg ctc     1268
 Gly Arg Gly Phe Asn Thr Gly Val Ile Leu Leu Arg Leu Asp Arg Leu
         135                 140                 145

 cgg cag gct ggc tgg gag cag atg tgg agg ctg aca gcc agg cgg gag     1316
 Arg Gln Ala Gly Trp Glu Gln Met Trp Arg Leu Thr Ala Arg Arg Glu
     150                 155                 160

 ctc ctt agc ctg cct gcc acc tca ctg gct gac cag gac atc ttc aac     1364
 Leu Leu Ser Leu Pro Ala Thr Ser Leu Ala Asp Gln Asp Ile Phe Asn
 165                 170                 175                 180

 gct gtg atc aag gag cac ccg ggg cta gtg cag cgt ctg cct tgt gtc     1412
 Ala Val Ile Lys Glu His Pro Gly Leu Val Gln Arg Leu Pro Cys Val
                 185                 190                 195

 tgg aat gtg cag ctg tca gat cac aca ctg gcc gag cgc tgc tac tct     1460
 Trp Asn Val Gln Leu Ser Asp His Thr Leu Ala Glu Arg Cys Tyr Ser
             200                 205                 210

 gag gcg tct gac ctc aag gtg atc cac tgg aac tca cca aag aag ctt     1508
 Glu Ala Ser Asp Leu Lys Val Ile His Trp Asn Ser Pro Lys Lys Leu
         215                 220                 225

 cgg gtg aag aac aag cat gtg gaa ttc ttc cgc aat ttc tac ctg acc     1556
 Arg Val Lys Asn Lys His Val Glu Phe Phe Arg Asn Phe Tyr Leu Thr
     230                 235                 240

 ttc ctg gag tac gat ggg aac ctg ctg cgg aga gag ctc ttt gtg tgc     1604
 Phe Leu Glu Tyr Asp Gly Asn Leu Leu Arg Arg Glu Leu Phe Val Cys
 245                 250                 255                 260

 ccc agc cag ccc cca cct ggt gct gag cag ttg cag cag gcc ctg gca     1652
 Pro Ser Gln Pro Pro Pro Gly Ala Glu Gln Leu Gln Gln Ala Leu Ala
                 265                 270                 275

 caa ctg gac gag gaa gac ccc tgc ttt gag ttc cgg cag cag cag ctc     1700
 Gln Leu Asp Glu Glu Asp Pro Cys Phe Glu Phe Arg Gln Gln Gln Leu
             280                 285                 290

 act gtg cac cgt gtg cat gtc act ttc ctg ccc cat gaa ccg cca ccc     1748
 Thr Val His Arg Val His Val Thr Phe Leu Pro His Glu Pro Pro Pro
         295                 300                 305

 ccc cgg cct cac gat gtc acc ctt gtg gcc cag ctg tcc atg gac cgg     1796
 Pro Arg Pro His Asp Val Thr Leu Val Ala Gln Leu Ser Met Asp Arg
     310                 315                 320

 ctg cag atg ttg gaa gcc ctg tgc agg cac tgg cct ggc ccc atg agc     1844
 Leu Gln Met Leu Glu Ala Leu Cys Arg His Trp Pro Gly Pro Met Ser
 325                 330                 335                 340

 ctg gcc ttg tac ctg aca gac gca gaa gct cag cag ttc ctg cat ttc     1892
 Leu Ala Leu Tyr Leu Thr Asp Ala Glu Ala Gln Gln Phe Leu His Phe
                 345                 350                 355

 gtc gag gcc tca cca gtg ctt gct gcc cgg cag gac gtg gcc tac cat     1940
 Val Glu Ala Ser Pro Val Leu Ala Ala Arg Gln Asp Val Ala Tyr His
             360                 365                 370

 gtg gtg tac cgt gag ggg ccc cta tac ccc gtc aac cag ctt cgc aac     1988
 Val Val Tyr Arg Glu Gly Pro Leu Tyr Pro Val Asn Gln Leu Arg Asn
         375                 380                 385

 gtg gcc ttg gcc cag gcc ctc acg cct tac gtc ttc ctc agt gac att     2036
 Val Ala Leu Ala Gln Ala Leu Thr Pro Tyr Val Phe Leu Ser Asp Ile
     390                 395                 400

 gac ttc ctg cct gcc tat tct ctc tac gac tac ctc agg gcc tcc att     2084
 Asp Phe Leu Pro Ala Tyr Ser Leu Tyr Asp Tyr Leu Arg Ala Ser Ile
 405                 410                 415                 420

 gag cag ctg ggg ctg ggc agc cgg cgc aag gca gca ctg gtg gtg ccg     2132
 Glu Gln Leu Gly Leu Gly Ser Arg Arg Lys Ala Ala Leu Val Val Pro
                 425                 430                 435

 gca ttc gag acc ctg cgc tac cgc ttc agc ttc ccc cat tcc aag gtg     2180
 Ala Phe Glu Thr Leu Arg Tyr Arg Phe Ser Phe Pro His Ser Lys Val
             440                 445                 450

 gag ctg ttg gcc ttg ctg gat gcg ggc act ctc tac acc ttc agg tac     2228
 Glu Leu Leu Ala Leu Leu Asp Ala Gly Thr Leu Tyr Thr Phe Arg Tyr
         455                 460                 465

 cac gag tgg ccc cga ggc cac gca ccc aca gac tat gcc cgc tgg cgg     2276
 His Glu Trp Pro Arg Gly His Ala Pro Thr Asp Tyr Ala Arg Trp Arg
     470                 475                 480

 gag gct cag gcc ccg tac cgt gtg caa tgg gcg gcc aac tat gaa ccc     2324
 Glu Ala Gln Ala Pro Tyr Arg Val Gln Trp Ala Ala Asn Tyr Glu Pro
 485                 490                 495                 500

 tac gtg gtg gtg cca cga gac tgt ccc cgc tat gat cct cgc ttt gtg     2372
 Tyr Val Val Val Pro Arg Asp Cys Pro Arg Tyr Asp Pro Arg Phe Val
                 505                 510                 515

 ggc ttc ggc tgg aac aaa gtg gcc cac att gtg gag ctg gat gcc cag     2420
 Gly Phe Gly Trp Asn Lys Val Ala His Ile Val Glu Leu Asp Ala Gln
             520                 525                 530

 gaa tat gag ctc ctg gtg ctg ccc gag gcc ttc acc atc cat ctg ccc     2468
 Glu Tyr Glu Leu Leu Val Leu Pro Glu Ala Phe Thr Ile His Leu Pro
         535                 540                 545

 cac gct cca agc ctg gac atc tcc cgc ttc cgc tcc agc ccc acc tat     2516
 His Ala Pro Ser Leu Asp Ile Ser Arg Phe Arg Ser Ser Pro Thr Tyr
     550                 555                 560

 cgt gac tgc ctc cag gcc ctc aag gac gaa ttc cac cag gac ttg tcc     2564
 Arg Asp Cys Leu Gln Ala Leu Lys Asp Glu Phe His Gln Asp Leu Ser
 565                 570                 575                 580

 cgc cac cat ggg gct gct gcc ctc aaa tac ctc cca gcc ctg cag cag     2612
 Arg His His Gly Ala Ala Ala Leu Lys Tyr Leu Pro Ala Leu Gln Gln
                 585                 590                 595

 ccc cag agc cct gcc cga ggc tga ggctgggccg gcgctgcccc tcatcttagc    2666
 Pro Gln Ser Pro Ala Arg Gly 
             600

 attgggcaga caccagggca acctgccctc cgccatccct gctatttaaa ttatttaagg   2726

 tctctgggaa gggctggggc agagcatctg tggggtgggg tcttcccctt gctgctattg   2786

 tatggctggg gactggtctc tctctgcccc agccagtttg gggctggttc ccccatcttg   2846

 aattgtttat ccctttttca taattaaagt tttaaaacat caaaaaaaaa a            2897




      <210> 86
      <211> 1714
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(1497)

      <400> 86
 ctactatagg gaatttggcc ctcgaggcca gaattcggca cgagggctgt tgtgcgcgcc     60

 caggggtccc gcgggttttc gggcgcaggg tggcgcccgc ggcaggcggc ggcc  atg     117
                                                              Met
                                                                1

 aac ttc tcc gag gta ttc aag ctc tcc agc tta ctc tgc aag ttc tcc      165
 Asn Phe Ser Glu Val Phe Lys Leu Ser Ser Leu Leu Cys Lys Phe Ser
               5                  10                  15

 ccg gac ggc aag tac ctg gct tcc tgt gtc cag tac cgg tta gtg gtc      213
 Pro Asp Gly Lys Tyr Leu Ala Ser Cys Val Gln Tyr Arg Leu Val Val
          20                  25                  30

 cgg gat gtg aac acc ctt cag atc ctt cag ctg tac acg tgc cta gac      261
 Arg Asp Val Asn Thr Leu Gln Ile Leu Gln Leu Tyr Thr Cys Leu Asp
      35                  40                  45

 cag atc cag cac atc gag tgg tcg gca gac tcg ctc ttc atc ctg tgc      309
 Gln Ile Gln His Ile Glu Trp Ser Ala Asp Ser Leu Phe Ile Leu Cys
  50                  55                  60                  65

 gcc atg tac aag cga ggg ctg gtg cag gtc tgg tct tta gag cag ccc      357
 Ala Met Tyr Lys Arg Gly Leu Val Gln Val Trp Ser Leu Glu Gln Pro
                  70                  75                  80

 gaa tgg cac tgc aaa ata gac gag ggc tca gcc ggg ctg gtg gcc tcg      405
 Glu Trp His Cys Lys Ile Asp Glu Gly Ser Ala Gly Leu Val Ala Ser
              85                  90                  95

 tgc tgg agc ccg gac ggg cgc cac att ctc aac acc acg gaa ttc cat      453
 Cys Trp Ser Pro Asp Gly Arg His Ile Leu Asn Thr Thr Glu Phe His
         100                 105                 110

 ctg cgg ata acc gtc tgg tcc ttg tgc aca aaa tcc gtg tct tac atc      501
 Leu Arg Ile Thr Val Trp Ser Leu Cys Thr Lys Ser Val Ser Tyr Ile
     115                 120                 125

 aaa tac ccg aaa gct tgt ccg cag gga atc acc ttc acc agg gac ggc      549
 Lys Tyr Pro Lys Ala Cys Pro Gln Gly Ile Thr Phe Thr Arg Asp Gly
 130                 135                 140                 145

 cgc tac atg gcg ctg gca gaa cgg cgc gac tgc aaa gat tac gtg agc      597
 Arg Tyr Met Ala Leu Ala Glu Arg Arg Asp Cys Lys Asp Tyr Val Ser
                 150                 155                 160

 atc ttc gtc tgc agt gat tgg cag ctc ctg cgg cat ttt gat acg gac      645
 Ile Phe Val Cys Ser Asp Trp Gln Leu Leu Arg His Phe Asp Thr Asp
             165                 170                 175

 acc cag gat ctc aca ggg att gag tgg gcc cca aac ggc tgt gtg ctg      693
 Thr Gln Asp Leu Thr Gly Ile Glu Trp Ala Pro Asn Gly Cys Val Leu
         180                 185                 190

 gca gtg tgg gac acc tgc ttg gag tac aag att ctg ctg tac tca ttg      741
 Ala Val Trp Asp Thr Cys Leu Glu Tyr Lys Ile Leu Leu Tyr Ser Leu
     195                 200                 205

 gat ggc cgg ttg ttg tcc acg tac agc gct tac gag tgg tcc ctg ggc      789
 Asp Gly Arg Leu Leu Ser Thr Tyr Ser Ala Tyr Glu Trp Ser Leu Gly
 210                 215                 220                 225

 atc aag tct gtg gcc tgg agc ccc agc agt cag ttc ctg gca gtt ggg      837
 Ile Lys Ser Val Ala Trp Ser Pro Ser Ser Gln Phe Leu Ala Val Gly
                 230                 235                 240

 agc tat gat gga aag gtg cgc atc ctt aat cac gtg act tgg aaa atg      885
 Ser Tyr Asp Gly Lys Val Arg Ile Leu Asn His Val Thr Trp Lys Met
             245                 250                 255

 atc acg gag ttt ggg cat cct gca gcc att aat gat ccc aag ata gtg      933
 Ile Thr Glu Phe Gly His Pro Ala Ala Ile Asn Asp Pro Lys Ile Val
         260                 265                 270

 gtg tat aag gag gcc gag aag agc cca cag ctg gga ctg ggc tgc ctc      981
 Val Tyr Lys Glu Ala Glu Lys Ser Pro Gln Leu Gly Leu Gly Cys Leu
     275                 280                 285

 tcc ttc ccg ccg ccc cgg gcc ggg gcc ggc cct ctc ccg agc tca gag     1029
 Ser Phe Pro Pro Pro Arg Ala Gly Ala Gly Pro Leu Pro Ser Ser Glu
 290                 295                 300                 305

 agt aaa tat gag atc gcc tct gtc cca gtc tcc tta cag aca ctg aaa     1077
 Ser Lys Tyr Glu Ile Ala Ser Val Pro Val Ser Leu Gln Thr Leu Lys
                 310                 315                 320

 cct gtt acc gac aga gca aac ccg aaa atc ggc ata gga atg ctg gca     1125
 Pro Val Thr Asp Arg Ala Asn Pro Lys Ile Gly Ile Gly Met Leu Ala
             325                 330                 335

 ttt agt cct gac agc tac ttc ctg gcg aca agg aac gac aac att ccc     1173
 Phe Ser Pro Asp Ser Tyr Phe Leu Ala Thr Arg Asn Asp Asn Ile Pro
         340                 345                 350

 aat gcc gtc tgg gtc tgg gac att cag aag ctg agg ctg ttc gcg gtg     1221
 Asn Ala Val Trp Val Trp Asp Ile Gln Lys Leu Arg Leu Phe Ala Val
     355                 360                 365

 ctc gag cag ctg tcc cca gtg cgc gcg ttt cag tgg gac ccg cag cag     1269
 Leu Glu Gln Leu Ser Pro Val Arg Ala Phe Gln Trp Asp Pro Gln Gln
 370                 375                 380                 385

 ccg cgg ctg gcc atc tgc acg gga ggc agc agg ctc tac ctg tgg tcc     1317
 Pro Arg Leu Ala Ile Cys Thr Gly Gly Ser Arg Leu Tyr Leu Trp Ser
                 390                 395                 400

 cca gcg ggc tgc atg tcg gtg cag gtg cct ggg gaa ggc gac ttt gca     1365
 Pro Ala Gly Cys Met Ser Val Gln Val Pro Gly Glu Gly Asp Phe Ala
             405                 410                 415

 gtg ctc tct ctg tgc tgg cat tta agc gga gac tcg atg gcc ctc ctc     1413
 Val Leu Ser Leu Cys Trp His Leu Ser Gly Asp Ser Met Ala Leu Leu
         420                 425                 430

 agc aag gat cac ttc tgc ctc tgc ttc ctg gag aca gag gca gtg gtc     1461
 Ser Lys Asp His Phe Cys Leu Cys Phe Leu Glu Thr Glu Ala Val Val
     435                 440                 445

 ggc aca gcc tgc aga cag ctg ggc ggc cac acg tag cagc ggtgcactaa     1511
 Gly Thr Ala Cys Arg Gln Leu Gly Gly His Thr 
 450                 455                 460

 cgtgtgcaga aacagggcta ctctgtgttt ccagtgtggg aaaaaacaca gcttcaccag   1571

 gaggttctcc actgtggtgg tctggattca gtgattgatt ctatttttct atagcaaagc   1631

 atttttgtaa atatgtatgg tataaaactg tagttttatt atttaaaata aatacttgct   1691

 gatttataca actaaaaaaa aaa                                           1714




      <210> 87
      <211> 2362
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (326)..(2176)

      <400> 87
 cggactcgta ctctatggtt gtccgcgctc tgcgcttcct ctctagccgc cagtgctcta     60

 tgctccgcgg tcgcgggccg ccagcctcca gccggccagc cgcgaggggt gcgcagaggg    120

 aggcggggcg gaaaggcgag aggtgtctcc tccaccggag ccaggggaga cccgagcaag    180

 ctccgtgaca gcacgtcggc cgccatgtcg ccgagtgggg ctggaaacag acccggcgcc    240

 cagcggtagc cctccttgcg cctccgattc ccagacatgg aaggtcttta atgtaacttt    300

 aaatggttca ccaaaggatg ctcta  atg gat gac agc gat act cct aca tat     352
                              Met Asp Asp Ser Asp Thr Pro Thr Tyr
                                1               5

 tat ctg caa ata gaa cca caa gat gga tgt cat cct ggt gac agc gtg      400
 Tyr Leu Gln Ile Glu Pro Gln Asp Gly Cys His Pro Gly Asp Ser Val
  10                  15                  20                  25

 gaa agg agt gtg acc tgt ctg cct tct gca tca gat gaa aat gaa aat      448
 Glu Arg Ser Val Thr Cys Leu Pro Ser Ala Ser Asp Glu Asn Glu Asn
                  30                  35                  40

 cag ctt gac ggg gac ggg cat gag cat ctg acc agc agt gac agt gcg      496
 Gln Leu Asp Gly Asp Gly His Glu His Leu Thr Ser Ser Asp Ser Ala
              45                  50                  55

 atg gga aag ccc caa gtg tct gag cag gac agt ctc aat aat aat gaa      544
 Met Gly Lys Pro Gln Val Ser Glu Gln Asp Ser Leu Asn Asn Asn Glu
          60                  65                  70

 agc tgc aca ttg agc tgc gag gtg gct gca ggt gag aac tcg caa aac      592
 Ser Cys Thr Leu Ser Cys Glu Val Ala Ala Gly Glu Asn Ser Gln Asn
      75                  80                  85

 acc ctt tgt gaa gcc tcc aga gat gaa cag gcc ttc ttg gga aag gac      640
 Thr Leu Cys Glu Ala Ser Arg Asp Glu Gln Ala Phe Leu Gly Lys Asp
  90                  95                 100                 105

 aaa aaa att cct gga aaa aga agt cca aga agc aaa aaa ggg act gct      688
 Lys Lys Ile Pro Gly Lys Arg Ser Pro Arg Ser Lys Lys Gly Thr Ala
                 110                 115                 120

 aag aag ata cca cca gga ctt ttt tca gga gat att gca cct tta atg      736
 Lys Lys Ile Pro Pro Gly Leu Phe Ser Gly Asp Ile Ala Pro Leu Met
             125                 130                 135

 caa gaa aaa gta cta agc gca gtc aca tat gct gtt gat gat gaa gaa      784
 Gln Glu Lys Val Leu Ser Ala Val Thr Tyr Ala Val Asp Asp Glu Glu
         140                 145                 150

 gct gct gaa gta aat gct aat gag cag cca gag gcg cca aag ctt gtt      832
 Ala Ala Glu Val Asn Ala Asn Glu Gln Pro Glu Ala Pro Lys Leu Val
     155                 160                 165

 ctg cag tct ctg ttt tca ctt ata cga ggt gaa gtt gag cag ttg gat      880
 Leu Gln Ser Leu Phe Ser Leu Ile Arg Gly Glu Val Glu Gln Leu Asp
 170                 175                 180                 185

 tca aga gca ctt ccc ctt tgc ctt cat cag ata gca gaa tcc tat ttc      928
 Ser Arg Ala Leu Pro Leu Cys Leu His Gln Ile Ala Glu Ser Tyr Phe
                 190                 195                 200

 cag gag gag gac tat gag aaa gca atg aaa ttc att cag cta gaa cga      976
 Gln Glu Glu Asp Tyr Glu Lys Ala Met Lys Phe Ile Gln Leu Glu Arg
             205                 210                 215

 ttg tat cat gag caa ttg ctc gca aat ctt tct gcc att caa gaa cag     1024
 Leu Tyr His Glu Gln Leu Leu Ala Asn Leu Ser Ala Ile Gln Glu Gln
         220                 225                 230

 tgg gaa aca aaa tgg aaa act gtg caa cca cat aca gtt acg gct cta     1072
 Trp Glu Thr Lys Trp Lys Thr Val Gln Pro His Thr Val Thr Ala Leu
     235                 240                 245

 agg aat tca gaa aag gga ttt aat ggt gaa gat ttt gaa cgg ctt acg     1120
 Arg Asn Ser Glu Lys Gly Phe Asn Gly Glu Asp Phe Glu Arg Leu Thr
 250                 255                 260                 265

 aaa att tgt gca aca cat caa gat cct ctt tta tcc aaa cat aag ata     1168
 Lys Ile Cys Ala Thr His Gln Asp Pro Leu Leu Ser Lys His Lys Ile
                 270                 275                 280

 gca gct gtg gag aag tcc cag gaa agg aaa tgc tcc acg cag tta cta     1216
 Ala Ala Val Glu Lys Ser Gln Glu Arg Lys Cys Ser Thr Gln Leu Leu
             285                 290                 295

 gtg tct gaa gat cca aag gaa gga gga gct acc acc aaa gag tca gag     1264
 Val Ser Glu Asp Pro Lys Glu Gly Gly Ala Thr Thr Lys Glu Ser Glu
         300                 305                 310

 agt aaa act tgt ctc ggc aca gag tca agt aaa gaa agc caa cat aca     1312
 Ser Lys Thr Cys Leu Gly Thr Glu Ser Ser Lys Glu Ser Gln His Thr
     315                 320                 325

 gtg gag ccc ctg ggg agc agt ccc tgc tgt cat cag atg gac gtg caa     1360
 Val Glu Pro Leu Gly Ser Ser Pro Cys Cys His Gln Met Asp Val Gln
 330                 335                 340                 345

 aca gat tcc cca agc ctt tcg gta act gca gga aag gac cac atg gag     1408
 Thr Asp Ser Pro Ser Leu Ser Val Thr Ala Gly Lys Asp His Met Glu
                 350                 355                 360

 gag ctg ctc tgc agc gct gaa gcc acg tta gcg ctc cac acc cag tcc     1456
 Glu Leu Leu Cys Ser Ala Glu Ala Thr Leu Ala Leu His Thr Gln Ser
             365                 370                 375

 tcc gag aca gca ggg agc ccg tct ggg cca gac tct tct gag gat gct     1504
 Ser Glu Thr Ala Gly Ser Pro Ser Gly Pro Asp Ser Ser Glu Asp Ala
         380                 385                 390

 tgt gag gat gac agt cgc ttg cag ctg gct caa aca gag gcc tgc cag     1552
 Cys Glu Asp Asp Ser Arg Leu Gln Leu Ala Gln Thr Glu Ala Cys Gln
     395                 400                 405

 gat gtg gcc aga ata gag ggc att gct gaa gac cct aag gtg ttt ctt     1600
 Asp Val Ala Arg Ile Glu Gly Ile Ala Glu Asp Pro Lys Val Phe Leu
 410                 415                 420                 425

 tcc agc aag tca aag aca gag ccg ttg att tca cca ggc tgt gac cgt     1648
 Ser Ser Lys Ser Lys Thr Glu Pro Leu Ile Ser Pro Gly Cys Asp Arg
                 430                 435                 440

 ata cct cct gca ttg att tct gag ggt aaa tat tca cag gct cag agg     1696
 Ile Pro Pro Ala Leu Ile Ser Glu Gly Lys Tyr Ser Gln Ala Gln Arg
             445                 450                 455

 aaa gaa ctc cgt ttg cca ctt cgg gat gct tct gag gcg ttg ccc aca     1744
 Lys Glu Leu Arg Leu Pro Leu Arg Asp Ala Ser Glu Ala Leu Pro Thr
         460                 465                 470

 gac caa ctt gag aac aat gaa tta aat gag ctg cag cag cct gat ctt     1792
 Asp Gln Leu Glu Asn Asn Glu Leu Asn Glu Leu Gln Gln Pro Asp Leu
     475                 480                 485

 aca gac agt gat gga aaa tca cca cag gcg cag gct gac tca gac ggt     1840
 Thr Asp Ser Asp Gly Lys Ser Pro Gln Ala Gln Ala Asp Ser Asp Gly
 490                 495                 500                 505

 tct gag aat gtg ctc tgt gga aat aat caa ata tct gac tta ggc ata     1888
 Ser Glu Asn Val Leu Cys Gly Asn Asn Gln Ile Ser Asp Leu Gly Ile
                 510                 515                 520

 ctg ctt cca gag gtg tgt atg gcc cca gag gaa aag gga gat aaa gac     1936
 Leu Leu Pro Glu Val Cys Met Ala Pro Glu Glu Lys Gly Asp Lys Asp
             525                 530                 535

 gac caa ctc aac aaa gaa aca gaa gac tat ttg aac agc ctt tta gaa     1984
 Asp Gln Leu Asn Lys Glu Thr Glu Asp Tyr Leu Asn Ser Leu Leu Glu
         540                 545                 550

 gga tgt tta aaa gat act gaa gat tcc ctt tcc tat gaa gat aac caa     2032
 Gly Cys Leu Lys Asp Thr Glu Asp Ser Leu Ser Tyr Glu Asp Asn Gln
     555                 560                 565

 gac gac gac tcc gat ctc ctt caa gat ctc tct cct gaa gaa gca tcc     2080
 Asp Asp Asp Ser Asp Leu Leu Gln Asp Leu Ser Pro Glu Glu Ala Ser
 570                 575                 580                 585

 tat agt ctc cag gag aat ctg cct tct gat gag agc tgt ctt tct ctt     2128
 Tyr Ser Leu Gln Glu Asn Leu Pro Ser Asp Glu Ser Cys Leu Ser Leu
                 590                 595                 600

 gat gat ctt gcc aaa agg ata gag att gca gag gta aat cag aga tga     2176
 Asp Asp Leu Ala Lys Arg Ile Glu Ile Ala Glu Val Asn Gln Arg 
             605                 610                 615

 agtacaatta aaagtaaaat ggcatttaaa aaacatatat atgtattaaa tattgccttg   2236

 tttttgtaag ttttcccttg tctcaaacat gagggaaaat tctagttaac gtaagctttt   2296

 aattattagt agtttttaca tttgtatgta ttgaataaaa tgacttttaa tcataaaaaa   2356

 aaaaaa                                                              2362




      <210> 88
      <211> 1393
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(1127)

      <400> 88
 cacagggccg ctcagaggcc gccgca atg ctc ccc tct ttg cag gag tcg atg      53
                              Met Leu Pro Ser Leu Gln Glu Ser Met
                                1               5

 gat gga gat gaa aag gaa cta gag agc agc gaa gag gga ggc tca gcc      101
 Asp Gly Asp Glu Lys Glu Leu Glu Ser Ser Glu Glu Gly Gly Ser Ala
  10                  15                  20                  25

 gag gag cgg aga ctc gag ccg ccg tcc agc agc cac tac tgt ctt tac      149
 Glu Glu Arg Arg Leu Glu Pro Pro Ser Ser Ser His Tyr Cys Leu Tyr
                  30                  35                  40

 agc tat cgc gga agc aga ttg gca cag caa cga ggg gac agt gag gac      197
 Ser Tyr Arg Gly Ser Arg Leu Ala Gln Gln Arg Gly Asp Ser Glu Asp
              45                  50                  55

 gga agc cca agt ggc aca aat gca gaa act ccc tct ggt gat gat ttc      245
 Gly Ser Pro Ser Gly Thr Asn Ala Glu Thr Pro Ser Gly Asp Asp Phe
          60                  65                  70

 agc ctc tcc ttg gca gat act aat cta cca tcc gaa gtg gag cca gag      293
 Ser Leu Ser Leu Ala Asp Thr Asn Leu Pro Ser Glu Val Glu Pro Glu
      75                  80                  85

 ctg cgc agt ttc att gct aag cgt ctt tca aga ggt gca gtc ttt gaa      341
 Leu Arg Ser Phe Ile Ala Lys Arg Leu Ser Arg Gly Ala Val Phe Glu
  90                  95                 100                 105

 ggg ctg ggt aat gtt gca tct gtg gag cta aaa att cca ggt tac cga      389
 Gly Leu Gly Asn Val Ala Ser Val Glu Leu Lys Ile Pro Gly Tyr Arg
                 110                 115                 120

 gtt ggt tgt tat tac tgc ctt ttc caa aat gaa aaa ctg ctt cct gaa      437
 Val Gly Cys Tyr Tyr Cys Leu Phe Gln Asn Glu Lys Leu Leu Pro Glu
             125                 130                 135

 aca gta acg ata gac tct gaa cgt aac cct tca gaa tat gtg gtc tgt      485
 Thr Val Thr Ile Asp Ser Glu Arg Asn Pro Ser Glu Tyr Val Val Cys
         140                 145                 150

 ttt tta gga ggg tct gaa aaa gga ctt gag ctt ttc agg ctt gaa ttg      533
 Phe Leu Gly Gly Ser Glu Lys Gly Leu Glu Leu Phe Arg Leu Glu Leu
     155                 160                 165

 gac aag tac att caa ggg ctg aaa aat aac atg aat tgt gag gca agg      581
 Asp Lys Tyr Ile Gln Gly Leu Lys Asn Asn Met Asn Cys Glu Ala Arg
 170                 175                 180                 185

 ggc ctg gag agt cac ata aaa tcc tat ctg agc agc tgg ttt gag gat      629
 Gly Leu Glu Ser His Ile Lys Ser Tyr Leu Ser Ser Trp Phe Glu Asp
                 190                 195                 200

 gtt gta tgc cca atc caa agg gtt gtt ctt ctc ttt cag gaa aag ctt      677
 Val Val Cys Pro Ile Gln Arg Val Val Leu Leu Phe Gln Glu Lys Leu
             205                 210                 215

 acc ttt ctg cta cat gct gct ttg agt tac act cct gtt gaa gtt aaa      725
 Thr Phe Leu Leu His Ala Ala Leu Ser Tyr Thr Pro Val Glu Val Lys
         220                 225                 230

 gaa tca gat gaa aaa aca aag aga gac att aac agg ttt ctg agt gtg      773
 Glu Ser Asp Glu Lys Thr Lys Arg Asp Ile Asn Arg Phe Leu Ser Val
     235                 240                 245

 gcc agt ctt caa gga ctt att cat gaa ggc acc atg act tct ttg tgc      821
 Ala Ser Leu Gln Gly Leu Ile His Glu Gly Thr Met Thr Ser Leu Cys
 250                 255                 260                 265

 atg gcc atg aca gag gag cag cat aag tct gtg gtc atc gat tgc agc      869
 Met Ala Met Thr Glu Glu Gln His Lys Ser Val Val Ile Asp Cys Ser
                 270                 275                 280

 agc tcc cag cct cag ttc tgc aat gca gga agt aac cgg ttt tgt gag      917
 Ser Ser Gln Pro Gln Phe Cys Asn Ala Gly Ser Asn Arg Phe Cys Glu
             285                 290                 295

 gat tgg atg caa gct ttt tta aat ggt gcc aaa gga ggt aac cct ttt      965
 Asp Trp Met Gln Ala Phe Leu Asn Gly Ala Lys Gly Gly Asn Pro Phe
         300                 305                 310

 ctt ttc cga caa gta ctg gag aac ttt aaa cta aag gcc ata caa gac     1013
 Leu Phe Arg Gln Val Leu Glu Asn Phe Lys Leu Lys Ala Ile Gln Asp
     315                 320                 325

 aca aac aat ttg aag aga ttt atc cga cag gca gaa atg aat cat tat     1061
 Thr Asn Asn Leu Lys Arg Phe Ile Arg Gln Ala Glu Met Asn His Tyr
 330                 335                 340                 345

 gct ttg ttt aaa tgt tac atg ttc cta aag aac tgt ggt agt gga gat     1109
 Ala Leu Phe Lys Cys Tyr Met Phe Leu Lys Asn Cys Gly Ser Gly Asp
                 350                 355                 360

 act ttt gaa gat tgt taa agtgga acatgaagaa atgcctgaag ccaaaaatgt     1163
 Thr Phe Glu Asp Cys 
             365

 gatagctgtc cttgaagaat tcatgaaaga agctcttgac caaagttttt gatcatatgt   1223

 tttgagataa ttgtatgatc aagttgtata tttaagtctt agtgtttgaa attgcagtta   1283

 taattgttca taggattgct atttaagatg atttgaaact caatccagat tttctttttg   1343

 tattttacca atttaactta aataaaaatc tgaagaacaa aaaaaaaaaa              1393




      <210> 89
      <211> 2714
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (259)..(1596)

      <400> 89
 gggagaggga gctctcgggt cggggctagg gaaggctgaa ccccgctcgg cccgggtgaa     60

 agggcggtga cggcactggg tggggccgag ctccagggct ggctgctggg ctgctaaggg    120

 aactgtgagc cgctcagagc cgcgcgcctc ccgggcgggg cggggccggc cgtgggagtc    180

 cgcgcgtgcc cgcgccgagc tgcctgctcc ggcggcttcg ctgctagctc gcggcgacgt    240

 cgggccgatt ttcccagg  atg aca gag ctg agg cag agg gtg gcc cat gag     291
                      Met Thr Glu Leu Arg Gln Arg Val Ala His Glu
                        1               5                  10

 ccg gtt gcg cca ccc gag gac aag gag tca gag tca gaa gca aag gta      339
 Pro Val Ala Pro Pro Glu Asp Lys Glu Ser Glu Ser Glu Ala Lys Val
              15                  20                  25

 gat gga gag act gca tcg gac agt gag agc cgg gca gaa tcc gca ccc      387
 Asp Gly Glu Thr Ala Ser Asp Ser Glu Ser Arg Ala Glu Ser Ala Pro
          30                  35                  40

 ctg cca gtc tct gca gat gat acc ccg gag gtc ctc aat agg gcc ctt      435
 Leu Pro Val Ser Ala Asp Asp Thr Pro Glu Val Leu Asn Arg Ala Leu
      45                  50                  55

 tcc aac ttg tct tca aga tgg aag aac tgg tgg gtg aga ggc atc ctg      483
 Ser Asn Leu Ser Ser Arg Trp Lys Asn Trp Trp Val Arg Gly Ile Leu
  60                  65                  70                  75

 act ttg gcc atg att gca ttt ttc ttc atc atc att tac ctg gga cca      531
 Thr Leu Ala Met Ile Ala Phe Phe Phe Ile Ile Ile Tyr Leu Gly Pro
                  80                  85                  90

 atg gtt ttg atg ata atc gtg atg tgc gtt cag att aag tgt ttc cat      579
 Met Val Leu Met Ile Ile Val Met Cys Val Gln Ile Lys Cys Phe His
              95                 100                 105

 gag ata atc act att ggc tac aac gtc tac cac tca tat gat ctg ccc      627
 Glu Ile Ile Thr Ile Gly Tyr Asn Val Tyr His Ser Tyr Asp Leu Pro
         110                 115                 120

 tgg ttc agg acg ctc agc tgg tac ttt ctc ctg tgt gta aac tat ttc      675
 Trp Phe Arg Thr Leu Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe
     125                 130                 135

 ttc tat ggt gag aca gtg acg gat tac ttc ttc acc ctg gtc cag aga      723
 Phe Tyr Gly Glu Thr Val Thr Asp Tyr Phe Phe Thr Leu Val Gln Arg
 140                 145                 150                 155

 gaa gag cct ttg cgg att ctc agt aaa tac cac cgg ttc att tcc ttt      771
 Glu Glu Pro Leu Arg Ile Leu Ser Lys Tyr His Arg Phe Ile Ser Phe
                 160                 165                 170

 act ctc tat cta ata gga ttc tgc atg ttt gta ctg agt ctg gtc aag      819
 Thr Leu Tyr Leu Ile Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys
             175                 180                 185

 aag cat tat cga ctg cag ttc tac atg ttt ggc tgg acc cat gtg aca      867
 Lys His Tyr Arg Leu Gln Phe Tyr Met Phe Gly Trp Thr His Val Thr
         190                 195                 200

 ttg ctg att gtt gta aca cag tca cat ctt gtt atc cac aac cta ttt      915
 Leu Leu Ile Val Val Thr Gln Ser His Leu Val Ile His Asn Leu Phe
     205                 210                 215

 gaa gga atg atc tgg ttc att gtc ccc ata tct tgt gtg atc tgt aat      963
 Glu Gly Met Ile Trp Phe Ile Val Pro Ile Ser Cys Val Ile Cys Asn
 220                 225                 230                 235

 gac atc atg gcc tat atg ttt ggc ttt ttc ttt ggt cgg acc cca ctc     1011
 Asp Ile Met Ala Tyr Met Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu
                 240                 245                 250

 atc aag ctg tcc ccg aag aag acc tgg gaa ggc ttc att ggg ggc ttc     1059
 Ile Lys Leu Ser Pro Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe
             255                 260                 265

 ttt gct act gtg gtg ttt ggc ctt ctg ctg tcc tat gtg atg tcc ggg     1107
 Phe Ala Thr Val Val Phe Gly Leu Leu Leu Ser Tyr Val Met Ser Gly
         270                 275                 280

 tac aga tgc ttt gtc tgc cct gtg gag tac aac aat gac acc aac agc     1155
 Tyr Arg Cys Phe Val Cys Pro Val Glu Tyr Asn Asn Asp Thr Asn Ser
     285                 290                 295

 ttc act gtg gac tgt gag ccc tcg gac ctg ttt cgc ctg cag gag tac     1203
 Phe Thr Val Asp Cys Glu Pro Ser Asp Leu Phe Arg Leu Gln Glu Tyr
 300                 305                 310                 315

 aac att cct ggg gtg atc cag tca gtc att ggc tgg aaa acg gtc cgg     1251
 Asn Ile Pro Gly Val Ile Gln Ser Val Ile Gly Trp Lys Thr Val Arg
                 320                 325                 330

 atg tac ccc ttc cag att cac agc atc gct ctc tcc acc ttt gcc tcg     1299
 Met Tyr Pro Phe Gln Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser
             335                 340                 345

 ctc att ggc ccc ttt gga gga ttc ttc gca agt gga ttc aaa cga gcc     1347
 Leu Ile Gly Pro Phe Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala
         350                 355                 360

 ttt aaa atc aaa gac ttt gcc aat acc att cct ggc cat gga ggc atc     1395
 Phe Lys Ile Lys Asp Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile
     365                 370                 375

 atg gat cgc ttt gac tgc cag tat ctg atg gcc acc ttt gtc aat gta     1443
 Met Asp Arg Phe Asp Cys Gln Tyr Leu Met Ala Thr Phe Val Asn Val
 380                 385                 390                 395

 tac atc gcc agt ttt atc aga ggc cct aac cca agc aaa ctg att cag     1491
 Tyr Ile Ala Ser Phe Ile Arg Gly Pro Asn Pro Ser Lys Leu Ile Gln
                 400                 405                 410

 cag ttc ctg act tta cgg cca gat cag cag ctc cac atc ttc aac acg     1539
 Gln Phe Leu Thr Leu Arg Pro Asp Gln Gln Leu His Ile Phe Asn Thr
             415                 420                 425

 ctg cgg tct cat ctg atc gac aaa ggg atg ctg aca tcc acc aca gag     1587
 Leu Arg Ser His Leu Ile Asp Lys Gly Met Leu Thr Ser Thr Thr Glu
         430                 435                 440

 gac gag tag gggccac ccagggccag gagaacagga acagaactga gcaggggcag     1643
 Asp Glu 
     445

 gtctccaagg caagcccagc tggtgtgact tagacaatga cgaggcttca actcactgtc   1703

 tttttttttt tttttggagg gtatttttta tttgtgggtt caaaaaatct gtatatacag   1763

 tctatgtgtt tagaatttgt gttgtaagta aactacagct ttgagttgga aagaagtcac   1823

 gggttgtaaa accatttgga tttttttaaa acaaaagtat taataatctg gaagacagtg   1883

 ttgcccaggt caggagtgtt ttcttggtgg ttccagcccc catcaattga actgtttctg   1943

 ggctcagtca gacacagaca ttcatctgtg tctgaccaaa tcaggggact tccccacctg   2003

 tggtgggagg cacagcttag atgttttgta cacctggtct tttctagaaa tccctgcttg   2063

 gagctgcaga agggttgcct tctgtaggtc ggaggaatgg aggcttacta accaggtaag   2123

 ccttctatgc atccacacca aaatcctgca gaatgtaagt aagctctgct ttataagatg   2183

 ggttcacctt catcgcagac tgaaagtttc agtttttatt tttttcagaa agcacgaaaa   2243

 attatttata atagtctgga gaaaaaacac actgtaatat ttcaagtgta tgcagtagaa   2303

 tgtactgtaa ctgagccctt tcccacatgt ctaggctcca atgtctcctg taggtccacc   2363

 taactgtgtg ttttcaggga caatgccatc catgtttgtg ctgtagactt gctgctgctg   2423

 aatcctttct ggggactttc tcatcgggca gggagcagag ggcttctcgt tcatgcaccc   2483

 tttgcctgaa cacccatgta gctgctgtgt tgtgtatata ttactcttaa gaggagtgtg   2543

 tgtgtctgtg tttgttttaa aagtcactta tttcttacag tgatttcaat tgcaccatga   2603

 cttcttcact aaaaccacaa agtcctgctt aaaactatgg aaaacctaac ctgattagag   2663

 ccttgactat tttgaagatt aaatgcacac tttttatata aaaaaaaaaa a            2714




      <210> 90
      <211> 2113
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (173)..(1462)

      <400> 90
 caatgaggac acactgcatg atcactgtgg ttggtccaca tgcaaccagt aagcacccca     60

 gtccctggct cgctccctag atgacccctg gccagcctgg gcctcctgca tccgcagtga    120

 ggtggggtcc agcctgtgat ggggaggaag gaagccccag gcagacaggc cc    atg     175
                                                              Met
                                                                1

 gtc aca agg ccc cct cca cag gcc aga ctg gcg gcc ttg aaa cgg cca      223
 Val Thr Arg Pro Pro Pro Gln Ala Arg Leu Ala Ala Leu Lys Arg Pro
               5                  10                  15

 gac gac gtc cca ctc agc ctc tct ccc agc aag cgg gcg tgt gcc tcc      271
 Asp Asp Val Pro Leu Ser Leu Ser Pro Ser Lys Arg Ala Cys Ala Ser
          20                  25                  30

 ccg tcg gcc cag gtg gag ggc agc cct gtg gca ggc tcc gat ggc agc      319
 Pro Ser Ala Gln Val Glu Gly Ser Pro Val Ala Gly Ser Asp Gly Ser
      35                  40                  45

 cag cct gct gtg aag ctg gag ccc ctg cac ttc ctg cag tgc cac agc      367
 Gln Pro Ala Val Lys Leu Glu Pro Leu His Phe Leu Gln Cys His Ser
  50                  55                  60                  65

 aag aac aac agc ccc cag gac ctc gag acc cag ctg tgg gcc tgt gcc      415
 Lys Asn Asn Ser Pro Gln Asp Leu Glu Thr Gln Leu Trp Ala Cys Ala
                  70                  75                  80

 ttc gag ccg gcc tgg gag gag ggg gcc aca tcc cag acc gtg gcc acg      463
 Phe Glu Pro Ala Trp Glu Glu Gly Ala Thr Ser Gln Thr Val Ala Thr
              85                  90                  95

 tgc ggc ggg gag gct gtg tgc gta att gat tgc cag acg ggc atc gtg      511
 Cys Gly Gly Glu Ala Val Cys Val Ile Asp Cys Gln Thr Gly Ile Val
         100                 105                 110

 ctc cac aag tac aag gca ccc ggc gag gag ttc ttt tct gtg gcc tgg      559
 Leu His Lys Tyr Lys Ala Pro Gly Glu Glu Phe Phe Ser Val Ala Trp
     115                 120                 125

 acc gct ctg atg gtg gtc aca cag gct ggc cac aag aag cgc tgg agt      607
 Thr Ala Leu Met Val Val Thr Gln Ala Gly His Lys Lys Arg Trp Ser
 130                 135                 140                 145

 gtg ctg gcg gct gca ggc cta cgg ggc ctg gtc cgg ctg ctg cac gtg      655
 Val Leu Ala Ala Ala Gly Leu Arg Gly Leu Val Arg Leu Leu His Val
                 150                 155                 160

 cgt gcc ggc ttc tgc tgc ggg gtc atc cga gcc cac aag aag gcc atc      703
 Arg Ala Gly Phe Cys Cys Gly Val Ile Arg Ala His Lys Lys Ala Ile
             165                 170                 175

 gcc acc ctg tgc ttc agc ccc gcc cac gag acc cat ctc ttc acg gcc      751
 Ala Thr Leu Cys Phe Ser Pro Ala His Glu Thr His Leu Phe Thr Ala
         180                 185                 190

 tcc tat gac aag cgg atc atc ctc tgg gac atc ggg gtg ccc aac cag      799
 Ser Tyr Asp Lys Arg Ile Ile Leu Trp Asp Ile Gly Val Pro Asn Gln
     195                 200                 205

 gac tac gaa ttc cag gcc agc cag ctg ctc aca ctg gac acc acc tct      847
 Asp Tyr Glu Phe Gln Ala Ser Gln Leu Leu Thr Leu Asp Thr Thr Ser
 210                 215                 220                 225

 atc ccc ctg cgc ctc tgc cct gtc gcc tcc tgc ccg gac gcc cgc ctg      895
 Ile Pro Leu Arg Leu Cys Pro Val Ala Ser Cys Pro Asp Ala Arg Leu
                 230                 235                 240

 ctg gcc ggc tgc gag ggc ggc tgc tgc tgc tgg gac gtg cgg ctg gac      943
 Leu Ala Gly Cys Glu Gly Gly Cys Cys Cys Trp Asp Val Arg Leu Asp
             245                 250                 255

 cag ccc caa aag agg agg gtg tgt gaa gtg gaa ttc gtc ttc tct gag      991
 Gln Pro Gln Lys Arg Arg Val Cys Glu Val Glu Phe Val Phe Ser Glu
         260                 265                 270

 ggc tcc gag gca tct gga cgg aga gtg gat ggg ctg gca ttt gtg aat     1039
 Gly Ser Glu Ala Ser Gly Arg Arg Val Asp Gly Leu Ala Phe Val Asn
     275                 280                 285

 gag gac atc gtg gcc tcc aag ggg agc ggc ctg ggc acc atc tgc ctg     1087
 Glu Asp Ile Val Ala Ser Lys Gly Ser Gly Leu Gly Thr Ile Cys Leu
 290                 295                 300                 305

 tgg agc tgg agg cag acg tgg ggg ggc cgg ggc agc cag tcc aca gtg     1135
 Trp Ser Trp Arg Gln Thr Trp Gly Gly Arg Gly Ser Gln Ser Thr Val
                 310                 315                 320

 gca gtg gtg gtc ctg gcg cgg ctg caa tgg tcg tcc acc gag ttg gcc     1183
 Ala Val Val Val Leu Ala Arg Leu Gln Trp Ser Ser Thr Glu Leu Ala
             325                 330                 335

 tac ttc tcg ctc agc gcc tgc cct gat aag ggg att gtg ctc tgt ggg     1231
 Tyr Phe Ser Leu Ser Ala Cys Pro Asp Lys Gly Ile Val Leu Cys Gly
         340                 345                 350

 gat gag gag ggc aac gtg tgg ctc tac gac gtc agc aac atc ctg aag     1279
 Asp Glu Glu Gly Asn Val Trp Leu Tyr Asp Val Ser Asn Ile Leu Lys
     355                 360                 365

 cag cca ccc ctg ctg ccg gca gcc ctg cag gcc ccc aca cag atc ctg     1327
 Gln Pro Pro Leu Leu Pro Ala Ala Leu Gln Ala Pro Thr Gln Ile Leu
 370                 375                 380                 385

 aag tgg ccc cag ccc tgg gcc ctt ggc cag gtg gtg acc aag acc atg     1375
 Lys Trp Pro Gln Pro Trp Ala Leu Gly Gln Val Val Thr Lys Thr Met
                 390                 395                 400

 gtg aac aca gtg gtg gcc aat gcc tcc ttc acc tac ctc acc gcc ctg     1423
 Val Asn Thr Val Val Ala Asn Ala Ser Phe Thr Tyr Leu Thr Ala Leu
             405                 410                 415

 acg gac tcc aac atc gta gcc atc tgg ggg agg atg tag cctcacacca      1472
 Thr Asp Ser Asn Ile Val Ala Ile Trp Gly Arg Met 
         420                 425

 tcgcaaagga ccagggacac agctaactaa cttattcagc tttgggccga tgggggtggg   1532

 gggggtcttt cagtgaatat ttttattaaa ctctactgtg gacaagaaaa acacacagcc   1592

 agaaaccccg agaactacac accaaccaac cggcggggcg cctccacaaa tacccccgag   1652

 cggggccaga tatgaccccc ccccgacctt cccttctcac agaggtggcc acataagggc   1712

 agcacgcaca taacacacgt cgcacacagc ccccgccagc tcacaccaca ggtgcgggac   1772

 ggggaaacac cgaagagacg gcggaaactt ggacggagga gacccacagc gagggggggc   1832

 cacctaggtg gcaaacgcca ccacagacaa gtaagcgcgg cggggaacat acaccttcac   1892

 cgtcgtcagg tggatgacca gaccgcatgg cgcgcggtga gcatgcgcaa cggcattgtc   1952

 ttcgacaatt cacgcccgca gacaaggcgg cacagcagac gacgcaccac cacgaaaccg   2012

 cgcacgacac accgcaagcg ggcagcggac acgaccgagc gcgagcgaac ccacgccatc   2072

 aggcgtcagc aacgtcgctc acacgagccg caacgctgca c                       2113




      <210> 91
      <211> 1871
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1668)

      <400> 91
  atg gac gtc agc tct gag cac act aag gac ccc ggc ggg gaa ggc gga      48
  Met Asp Val Ser Ser Glu His Thr Lys Asp Pro Gly Gly Glu Gly Gly
    1               5                  10                  15

 gac ggg gaa agc ctg gcc gcg cgg ccg tcc aag atc aag gcc agc tct       96
 Asp Gly Glu Ser Leu Ala Ala Arg Pro Ser Lys Ile Lys Ala Ser Ser
              20                  25                  30

 ggc cct ccg acc tct ccc gaa ccc ggg gag ctg gag tcg gag ccg gag      144
 Gly Pro Pro Thr Ser Pro Glu Pro Gly Glu Leu Glu Ser Glu Pro Glu
          35                  40                  45

 gag gag gag gag gag caa gcg gct tcg cag gga ggc acc gcc gcg gac      192
 Glu Glu Glu Glu Glu Gln Ala Ala Ser Gln Gly Gly Thr Ala Ala Asp
      50                  55                  60

 gag cag gcc gag gcc ccg aaa ggg cta acg gca gcc gag gct gcg ggc      240
 Glu Gln Ala Glu Ala Pro Lys Gly Leu Thr Ala Ala Glu Ala Ala Gly
  65                  70                  75                  80

 gag gag ggg cct gga gag ccg ggg agg ccg gcc gag ccc cag ccc gag      288
 Glu Glu Gly Pro Gly Glu Pro Gly Arg Pro Ala Glu Pro Gln Pro Glu
                  85                  90                  95

 ccc gaa gag ccg gcc gag gtt ggg gct gag gag ccc gcc cag ccg gag      336
 Pro Glu Glu Pro Ala Glu Val Gly Ala Glu Glu Pro Ala Gln Pro Glu
             100                 105                 110

 ccc gga gcc ggg ccc gag gaa cta gag gcg gag gcg ggg gcg gag gaa      384
 Pro Gly Ala Gly Pro Glu Glu Leu Glu Ala Glu Ala Gly Ala Glu Glu
         115                 120                 125

 ctg gag cag gcg gca gag ggg aag gaa gtc agg ttc cag gcc tct ctg      432
 Leu Glu Gln Ala Ala Glu Gly Lys Glu Val Arg Phe Gln Ala Ser Leu
     130                 135                 140

 ccg ctg acc agg atc gat gag gaa gag gct gct gca gcc ccg gag gcc      480
 Pro Leu Thr Arg Ile Asp Glu Glu Glu Ala Ala Ala Ala Pro Glu Ala
 145                 150                 155                 160

 gag aca gag cgg gtg gag ggg gag gaa gag gac aag gag gag acg cag      528
 Glu Thr Glu Arg Val Glu Gly Glu Glu Glu Asp Lys Glu Glu Thr Gln
                 165                 170                 175

 aga gac ggc gcg gag agc aag gag agg gat ggg gaa gga cgc ccg gcc      576
 Arg Asp Gly Ala Glu Ser Lys Glu Arg Asp Gly Glu Gly Arg Pro Ala
             180                 185                 190

 aaa agc cag gaa gag ggg aag cgc ctc tat gga agg gac gag ttt gag      624
 Lys Ser Gln Glu Glu Gly Lys Arg Leu Tyr Gly Arg Asp Glu Phe Glu
         195                 200                 205

 gac ctc gag tgg tcc gag gag gtc cag aag ctg cag gag cag cag ctg      672
 Asp Leu Glu Trp Ser Glu Glu Val Gln Lys Leu Gln Glu Gln Gln Leu
     210                 215                 220

 cgc agc gac ctc ctg gac cag tac cgt tcc ctg ctg gtg gag cgg aac      720
 Arg Ser Asp Leu Leu Asp Gln Tyr Arg Ser Leu Leu Val Glu Arg Asn
 225                 230                 235                 240

 cgc tcc cag cgc tac aac cta tac ctg cag cac aag atc ttc gag gcg      768
 Arg Ser Gln Arg Tyr Asn Leu Tyr Leu Gln His Lys Ile Phe Glu Ala
                 245                 250                 255

 ctg cgc aga aag aag ggc ctg gag gcc gct gag gtg gct gac cgg ggc      816
 Leu Arg Arg Lys Lys Gly Leu Glu Ala Ala Glu Val Ala Asp Arg Gly
             260                 265                 270

 gca gag gcc gag gcc ccc gag aaa gag caa gcg tac ctg cgc cat ctg      864
 Ala Glu Ala Glu Ala Pro Glu Lys Glu Gln Ala Tyr Leu Arg His Leu
         275                 280                 285

 ggc atg ctg gag gag ctg aag aag cag cag gca gac gac ctg cag tgg      912
 Gly Met Leu Glu Glu Leu Lys Lys Gln Gln Ala Asp Asp Leu Gln Trp
     290                 295                 300

 tac cac cag gag ctg ggc cag ttg aag cgg cag tgc cag gag aag ctc      960
 Tyr His Gln Glu Leu Gly Gln Leu Lys Arg Gln Cys Gln Glu Lys Leu
 305                 310                 315                 320

 acc agg gtg gag aag gag tgg cga cgc ttc cag gca ctc aag aag cag     1008
 Thr Arg Val Glu Lys Glu Trp Arg Arg Phe Gln Ala Leu Lys Lys Gln
                 325                 330                 335

 gtg gtg atg cag gcc atg ggc agc tgt cgg atg agg ggc ggg cgc cag     1056
 Val Val Met Gln Ala Met Gly Ser Cys Arg Met Arg Gly Gly Arg Gln
             340                 345                 350

 gct gct ctg cga gag gtg gag cag atc cag gcg ttg gag gat aaa aag     1104
 Ala Ala Leu Arg Glu Val Glu Gln Ile Gln Ala Leu Glu Asp Lys Lys
         355                 360                 365

 gag aag gag atg agc gcc gtg cgg ctg gag aac att cag ctg aag cag     1152
 Glu Lys Glu Met Ser Ala Val Arg Leu Glu Asn Ile Gln Leu Lys Gln
     370                 375                 380

 agc ctg gtg cat ttt gaa acc agg atg agg acc cag gag gac ctg acc     1200
 Ser Leu Val His Phe Glu Thr Arg Met Arg Thr Gln Glu Asp Leu Thr
 385                 390                 395                 400

 cag ggt ctg ctt ctt att gac ttt gaa cag ctg aag att gag aac caa     1248
 Gln Gly Leu Leu Leu Ile Asp Phe Glu Gln Leu Lys Ile Glu Asn Gln
                 405                 410                 415

 acc ttc aat gag aaa att gag gaa cga aat gag gaa ctt tta aaa ctt     1296
 Thr Phe Asn Glu Lys Ile Glu Glu Arg Asn Glu Glu Leu Leu Lys Leu
             420                 425                 430

 cgc agc aag gtg acc aac agt gtg caa gta ata acc cac gtg aag gaa     1344
 Arg Ser Lys Val Thr Asn Ser Val Gln Val Ile Thr His Val Lys Glu
         435                 440                 445

 aag ctg cac ttc atg gac atg gag aac gcg tgc aaa aag aca cag ctg     1392
 Lys Leu His Phe Met Asp Met Glu Asn Ala Cys Lys Lys Thr Gln Leu
     450                 455                 460

 gca gaa atc gag gcc cag gcc gcc cta gga aga gac atc ctg acc aag     1440
 Ala Glu Ile Glu Ala Gln Ala Ala Leu Gly Arg Asp Ile Leu Thr Lys
 465                 470                 475                 480

 acg aag caa gcc cga gag ggg ctg cgg acg gac aac atc aga ctg aat     1488
 Thr Lys Gln Ala Arg Glu Gly Leu Arg Thr Asp Asn Ile Arg Leu Asn
                 485                 490                 495

 cag aag tgc ggc ctt cta ggc aag gac tca ctt ctt cgg gac ttg gaa     1536
 Gln Lys Cys Gly Leu Leu Gly Lys Asp Ser Leu Leu Arg Asp Leu Glu
             500                 505                 510

 gaa aag gtg gac aag acc gaa ctg ctt cac cgg cgc ctg gaa tcc ctg     1584
 Glu Lys Val Asp Lys Thr Glu Leu Leu His Arg Arg Leu Glu Ser Leu
         515                 520                 525

 aag cgc cac cac gct agc ctc act ttg tcc tgc aga ggc gtg agg cag     1632
 Lys Arg His His Ala Ser Leu Thr Leu Ser Cys Arg Gly Val Arg Gln
     530                 535                 540

 aag atc agg gag gcc aaa gcc ttt ctc cct tct tga ccag atcgatgaga     1682
 Lys Ile Arg Glu Ala Lys Ala Phe Leu Pro Ser 
 545                 550                 555

 agagtctgca aaacacttca tcctcaggac gtgctgtcct gctttatttt accttcggtg   1742

 ctattaaaaa ggcctgtgtc atttgggacg ggactctatt ttggatttat ctcaaaacgt   1802

 tttagcttcc caataagtgc ttgaccccaa ccttgggtaa gaagtttatt tggggattga   1862

 ccaaaaaaa                                                           1871




      <210> 92
      <211> 4925
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (276)..(1847)

      <400> 92
 cgggggagaa caaattggct tggtctgagt cctgtttgct ttctggcact gtgtgggctg     60

 tcgatgctgg agcctgagct gcagcctgat gcctgtggcc gagcctgggc ctgggcctgt    120

 tgcccagtga tgcgctgctg gattattgct tgtgctgtgc caggctgggg tgtcgactgt    180

 gtgtccctga atgccctgct gcccctggtg ccatgcaatg gtgatgcccc tgctgcagtg    240

 cctgctgctg catccggagg cggccgggcc ccgcc   atg gcc ggg gtc agc tac     293
                                          Met Ala Gly Val Ser Tyr
                                            1               5

 gcg gcg ccc tgg tgg gtg agc ctc ctg cac cgg ctg ccc cac ttc gac      341
 Ala Ala Pro Trp Trp Val Ser Leu Leu His Arg Leu Pro His Phe Asp
              10                  15                  20

 ctg agc tgg gag gcc act agc agc cag ttc cgg ccc gag gac acc gac      389
 Leu Ser Trp Glu Ala Thr Ser Ser Gln Phe Arg Pro Glu Asp Thr Asp
          25                  30                  35

 tac cag cag gcc ctg ctg ctc ctg ggg gcc gcc gcc ctg gcc tgc ctc      437
 Tyr Gln Gln Ala Leu Leu Leu Leu Gly Ala Ala Ala Leu Ala Cys Leu
      40                  45                  50

 gcc ctg gac ctc ctc ttc ctg ctc ttc tac tcc ttc tgg ctg tgc tgc      485
 Ala Leu Asp Leu Leu Phe Leu Leu Phe Tyr Ser Phe Trp Leu Cys Cys
  55                  60                  65                  70

 cgg cgg cgc aag agc gag gag cac ctg gac gcc gac tgc tgc tgc acg      533
 Arg Arg Arg Lys Ser Glu Glu His Leu Asp Ala Asp Cys Cys Cys Thr
                  75                  80                  85

 gcc tgg tgt gtc atc atc gcc acg ctg gtg tgc agc gcc ggc atc gca      581
 Ala Trp Cys Val Ile Ile Ala Thr Leu Val Cys Ser Ala Gly Ile Ala
              90                  95                 100

 gtg gga ttc tac ggc aac ggg gag acc agt gat ggc atc cat agg gcc      629
 Val Gly Phe Tyr Gly Asn Gly Glu Thr Ser Asp Gly Ile His Arg Ala
         105                 110                 115

 acc tac tcg ctc cgc cac gcc aac cgc acg gtg gcc ggg gtc cag gac      677
 Thr Tyr Ser Leu Arg His Ala Asn Arg Thr Val Ala Gly Val Gln Asp
     120                 125                 130

 cgc gtg tgg gac acg gcg gtg ggg ctg aac cac acg gcg gag ccc agc      725
 Arg Val Trp Asp Thr Ala Val Gly Leu Asn His Thr Ala Glu Pro Ser
 135                 140                 145                 150

 ctg cag acc ctg gag cgg cag ctg gcc ggg cgg ccc gag ccc ctg cga      773
 Leu Gln Thr Leu Glu Arg Gln Leu Ala Gly Arg Pro Glu Pro Leu Arg
                 155                 160                 165

 gcc gta cag agg ctg cag ggc ctg ctg gag acg ctg ctg ggc tac acg      821
 Ala Val Gln Arg Leu Gln Gly Leu Leu Glu Thr Leu Leu Gly Tyr Thr
             170                 175                 180

 gcc gcc atc ccc ttt tgg agg aac acg gcg gtg tcg ctg gag gtg ctg      869
 Ala Ala Ile Pro Phe Trp Arg Asn Thr Ala Val Ser Leu Glu Val Leu
         185                 190                 195

 gcg gag cag gtg gat ctc tac gac tgg tac agg tgg ctg ggc tac ctg      917
 Ala Glu Gln Val Asp Leu Tyr Asp Trp Tyr Arg Trp Leu Gly Tyr Leu
     200                 205                 210

 ggc ctg ctg ctg ctg gac gtc atc atc tgc ctc ctg gtg ctg gtt ggc      965
 Gly Leu Leu Leu Leu Asp Val Ile Ile Cys Leu Leu Val Leu Val Gly
 215                 220                 225                 230

 ctc atc cgc agc tcc aag ggc atc ctg gtg ggg gtc tgc ctg ctg gga     1013
 Leu Ile Arg Ser Ser Lys Gly Ile Leu Val Gly Val Cys Leu Leu Gly
                 235                 240                 245

 gtc ctg gcc ctg gtc atc agc tgg ggc gcg ctg ggc ttg gag ctg gct     1061
 Val Leu Ala Leu Val Ile Ser Trp Gly Ala Leu Gly Leu Glu Leu Ala
             250                 255                 260

 gtg tcc gtg ggc tcc agc gac ttc tgt gtg gac cct gac gcc tac gtg     1109
 Val Ser Val Gly Ser Ser Asp Phe Cys Val Asp Pro Asp Ala Tyr Val
         265                 270                 275

 acc aaa atg gtg gag gag tac tcg gtg ctg agt ggg gac atc ctg cag     1157
 Thr Lys Met Val Glu Glu Tyr Ser Val Leu Ser Gly Asp Ile Leu Gln
     280                 285                 290

 tac tac ctg gcc tgc tcg ccc cgc gcc gcc aac ccc ttc cag cag aag     1205
 Tyr Tyr Leu Ala Cys Ser Pro Arg Ala Ala Asn Pro Phe Gln Gln Lys
 295                 300                 305                 310

 ctg tcg ggc agc cac aag gca ctg gtg gag atg cag gat gtc gtg gct     1253
 Leu Ser Gly Ser His Lys Ala Leu Val Glu Met Gln Asp Val Val Ala
                 315                 320                 325

 gag ctt ctg agg acc gtc ccc tgg gag cag ccg gcc act aag gac ccc     1301
 Glu Leu Leu Arg Thr Val Pro Trp Glu Gln Pro Ala Thr Lys Asp Pro
             330                 335                 340

 ctc ctc cgc gtc cag gag gtg ctg aat ggc acg gag gtg aac ctg cag     1349
 Leu Leu Arg Val Gln Glu Val Leu Asn Gly Thr Glu Val Asn Leu Gln
         345                 350                 355

 cac ctc acc gcc ctg gtg gac tgc cgc agc ctg cat ctg gac tac gtg     1397
 His Leu Thr Ala Leu Val Asp Cys Arg Ser Leu His Leu Asp Tyr Val
     360                 365                 370

 caa gcg ctg acc ggc ttc tgc tat gac ggc gtg gag ggc ctc atc tac     1445
 Gln Ala Leu Thr Gly Phe Cys Tyr Asp Gly Val Glu Gly Leu Ile Tyr
 375                 380                 385                 390

 ctg gcc ctc ttc tcc ttc gtc aca gcc ctc atg ttc agc tcc atc gtc     1493
 Leu Ala Leu Phe Ser Phe Val Thr Ala Leu Met Phe Ser Ser Ile Val
                 395                 400                 405

 tgc agc gtc ccg cac acc tgg cag caa aag aga ggc cct gat gag gac     1541
 Cys Ser Val Pro His Thr Trp Gln Gln Lys Arg Gly Pro Asp Glu Asp
             410                 415                 420

 ggg gag gag gag gcc gct cca ggg ccg cgg cag gcg cac gac agc ctc     1589
 Gly Glu Glu Glu Ala Ala Pro Gly Pro Arg Gln Ala His Asp Ser Leu
         425                 430                 435

 tac cgc gtc cac atg ccc agc ctg tac agc tgt ggc agc agc tac ggc     1637
 Tyr Arg Val His Met Pro Ser Leu Tyr Ser Cys Gly Ser Ser Tyr Gly
     440                 445                 450

 agt gag acc agc atc ccg gcc gcg gcc cac acc gtc agc aac gcc ccg     1685
 Ser Glu Thr Ser Ile Pro Ala Ala Ala His Thr Val Ser Asn Ala Pro
 455                 460                 465                 470

 gtc act gag tac atg agc cag aac gct aat ttc cag aac ccc cgc tgt     1733
 Val Thr Glu Tyr Met Ser Gln Asn Ala Asn Phe Gln Asn Pro Arg Cys
                 475                 480                 485

 gag aac acc cca ctc att ggg cgc gag tcc ccg ccg ccc tca tac acc     1781
 Glu Asn Thr Pro Leu Ile Gly Arg Glu Ser Pro Pro Pro Ser Tyr Thr
             490                 495                 500

 tcc agc atg aga gcc aaa tac ctc gcc acg agc cag cct cgc cct gac     1829
 Ser Ser Met Arg Ala Lys Tyr Leu Ala Thr Ser Gln Pro Arg Pro Asp
         505                 510                 515

 tcc agc ggc agc cac tag accgcg cccggcagcc acccacccca cgtgccaact     1883
 Ser Ser Gly Ser His 
     520

 tcccctcccc gtgccagcac tgccgcttcc acctgggcca cccaccggac cctcgcacgc   1943

 cgtgccaggc ctgccccaga cgcgtctgca ggccgcttgc cctcctgtcc cctccccgca   2003

 ggggcacagt ggagacgcag gggctctggg cccgtaccgc caactcgggt cacacctgaa   2063

 cgctgctgcc agccgatgcc ccagccctgc acgccaccca ctatcccggc acgctccctc   2123

 tgcagatggt cgccgcacct acaagccctg gccgcaccca acctgtgttg ttgccgcccg   2183

 gcccttccct ccacagctct ccttcctccc gcccggcact tctgtggacc ccttcttagt   2243

 tcacaggcac ggctggggcc gctctgtgct ggcgcctgct ggccactgag ggacagggac   2303

 acgtgccacc tgctcatctc tgccctgagg tcaccccgtg gtccctccac gtgcccatct   2363

 ctctgcagtg ccctcctcgc ctgtgcagcc cgcccaccca caggctcacc cctcctgccg   2423

 gctgccagag gccccctcca gcagggcctc tctccgttgc cccagcttca ctctctccct   2483

 cagcacctgc cctgctggag gccccagccc tccgtggaca gcaggggcca cgtggagccc   2543

 gggccgctca cccgccaccc agtgctggcc gccttcttgg tgccaaaccc ccttccccca   2603

 cccagagact gggcagctgt gtctggttcg ttctttgcac taaccacatt tgtcatctct   2663

 agggcaggct ggggctgcgg gctgaggggg accgctggca ccccccttcc ctcccttctt   2723

 ggttccattt ccatccatga caggtacagc atcccaggag cccggcctga ggggctggac   2783

 ccgagccggc tgtgaacatc cctcagcccc tgctgtcccc ccttgggact aaccactaac   2843

 ctcaccccca aactccacgg gtgcccctag ctggcccaga gccggcagtg tgagcccaag   2903

 tccgggctgg agccgaggcc ggagcagctg tctgggagtc aaggctgcag tagcgtttct   2963

 tcatggggtg ctccaggggg tgccacagac cgacaggcag cccaagggcc tggacacccc   3023

 tccccaggca ggtgctgccc caggaggact gtcctcggga atgaacctcc cgcgggcttt   3083

 ggactgaggt ccctgtggcc tcggtctcct ccccatgaag tgggagcgag gctccccaat   3143

 ggtgcttttg gctttagtgt acgatgtttg ctgtgcttcc cgccgtggag ggcagagcca   3203

 ccccacatca ggatcggacg tgctacccct cccggtcccg gccctggccc agccagccca   3263

 gccctcgagg ctcgatgcct gtgccaaggc caggggcagc cagagggcag ctggatggcc   3323

 acgtgcaggg gtcaaggctg ggccctgcag tggggcgggc cgccagcccc agcagtttac   3383

 agacgcatgg ctcttcctcc cagagcagcc ggcagctacc tggaccggaa atgtcctcat   3443

 cccctccctg gggccaggct ctgccctggc cttcctctgt gaacccctcc tttctttgtg   3503

 ctggtgtctg ggaccaaaaa gggggaatat gggagggcag agtggggagg ggagtccatg   3563

 ggcctggggc cccaagccgg ggcgtctgag ctccccaggc atgaccaaac ctcagtggag   3623

 gggcctctgc ttcaggcccc gcctggctga cattctgagc ccccctcgga ggccccgcca   3683

 cagccaacct gcccagtctt tcctctgggc ttgacccgcc aggggagttc tccaggccta   3743

 gggccaggag agaggccctg gcaccctggc gtgggtgccc gccaaacgcc ctgcgaccgc   3803

 tcagaagcac aaatgctgtc catggccgtg aggctgcctg ccaggtgaat ggacatagcg   3863

 tgagaggcgg tgaggccagg gcttccagcc tcgtgctgtc tcgggactcc tgaccgtggt   3923

 gtgcgtgtgt gcccgtctgt gactttctac tcaccaaggt tgaagaaagg aaacggggaa   3983

 aatcaaaagg ggttcaaacc ccacctcagt aggtggaggg gagcgcctgc cattggttgt   4043

 atttttgttc tgagttttcg gtgccgtgtt cctaactact ccatcccatg acctcgccac   4103

 acctactggg gcatctggct ggtgcctgct gccatggcca gcccccactc tcaccctgca   4163

 cagggggtct tgcagccccc aggcccacag cctcgttggg aggacagggt ggccctgggg   4223

 acaagaggga ggagcccagg ggcttacctc actgagagtg ctccccagca ggcatccact   4283

 accccagggc cccccacatg tcatggcaag gttggtagtg aatgggcctg gttgggagca   4343

 gcccctggcc cattgcccac ccacccatct cactatgcaa ttcgagttcc aagcaacatt   4403

 tgctcctgcc ctggggccag ctctgcccca gccctgagag gggtggtgag gcagccccct   4463

 ggaccccaga accccagaca agggggcagg cgggggacca gggcctctcc tgtgggatct   4523

 ttgttttgtg tttaaccata atggttgtgt actgaaccac ttcatatttg ttatatataa   4583

 tatatatata tataatctcc ttaagactca gcctcctggt ttaccccccc ggcctgggca   4643

 tctgacctcc cccaccccag tgtgatttaa catccaggaa ctgaggcctg aaccattttg   4703

 catttccccc tcctccagcc tctgtagggc catggctgta tgtactgtcg ctgtgttttt   4763

 ttgttttttt agaactgggt ttgggggctg atttttattt ctttgggggc tttttttctt   4823

 ggcaaatact aaaaatctcg tcaatgtaat ttctgtggtt tctattcagc ttgggtttca   4883

 tgttttaaaa taaattttaa aaagcaaaaa aaaaaaaaaa aa                      4925




      <210> 93
      <211> 1351
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (398)..(940)

      <400> 93
 ccacggacta catacgacat tatatgcgac tcactatagg gaccactttg tacaagaaag     60

 ctgggtacgc gtaagcttgg gcccctcgag gtattctcta gagcggccgc cctttttttt    120

 tttttttttt tttttttttt tttttttctg aaaacaagtt ttatttaaat aagggtttaa    180

 atacattaca cataacatta aaactgaagg ggaaaaaaaa accaaaaacc agtttgttac    240

 ttcacatggc attgggcagc tgctgctatt aagttgcaag ctcttcctgg gggcctggcc    300

 ccccctgtgt ggccgctaca agccctggcg taagcatggg gtctttgtgc tcctcaccac    360

 agccacctcc gttgccatat gggtggtgtg gatcgtc atg tat act tac ggc aac     415
                                          Met Tyr Thr Tyr Gly Asn
                                            1               5

 aag caa cac aac agt ccc acc tgg gat gac ccc acg ctg gcc atc gcc      463
 Lys Gln His Asn Ser Pro Thr Trp Asp Asp Pro Thr Leu Ala Ile Ala
              10                  15                  20

 ctc gcc gcc aat gcc tgg gcc ttc gtc ctc ttt tac gta atc ccc gag      511
 Leu Ala Ala Asn Ala Trp Ala Phe Val Leu Phe Tyr Val Ile Pro Glu
          25                  30                  35

 gtc tcc cag gtg acc aag tcc atc cca aag caa agc tac cag ggg gac      559
 Val Ser Gln Val Thr Lys Ser Ile Pro Lys Gln Ser Tyr Gln Gly Asp
      40                  45                  50

 atg tac ccc acc cgg ggc gtg ggc tat gag acc atc ctg aaa gag cag      607
 Met Tyr Pro Thr Arg Gly Val Gly Tyr Glu Thr Ile Leu Lys Glu Gln
  55                  60                  65                  70

 aag ggt cag agc atg ttc gtg gag aac aag gcc ttt tcc atg gat gag      655
 Lys Gly Gln Ser Met Phe Val Glu Asn Lys Ala Phe Ser Met Asp Glu
                  75                  80                  85

 ccg gtt gca gct aaa agg ccg gtg tca cca tac agc ggg tac aat ggg      703
 Pro Val Ala Ala Lys Arg Pro Val Ser Pro Tyr Ser Gly Tyr Asn Gly
              90                  95                 100

 cag ctg ctg acc agt gtg tac cag ccc act gag atg gcc ctg atg cac      751
 Gln Leu Leu Thr Ser Val Tyr Gln Pro Thr Glu Met Ala Leu Met His
         105                 110                 115

 aaa gtt ccg tcc gaa gga gct tac gac atc atc ctc cca cgg gcc acc      799
 Lys Val Pro Ser Glu Gly Ala Tyr Asp Ile Ile Leu Pro Arg Ala Thr
     120                 125                 130

 gcc aac agc cag gtg atg ggc agt gcc aac tcg acc ctg cgg gct gaa      847
 Ala Asn Ser Gln Val Met Gly Ser Ala Asn Ser Thr Leu Arg Ala Glu
 135                 140                 145                 150

 gac atg tac tcg gcc cag agc cac cag gcg gcc aca ccg ccg aaa gac      895
 Asp Met Tyr Ser Ala Gln Ser His Gln Ala Ala Thr Pro Pro Lys Asp
                 155                 160                 165

 ggc aag aac tct cag gtc ttt aga aac ccc tac gtg tgg gac tga gtc      943
 Gly Lys Asn Ser Gln Val Phe Arg Asn Pro Tyr Val Trp Asp 
             170                 175                 180

 agcggtggcg aggagaggcg ggcggatttg gggagggccc tgaggacctg gccccgggca   1003

 agggactctc caggctcctc ctccccctgg caggcccagc aacatgtgcc ccagatctgg   1063

 aagggcctcc ctctctgcca gtgtttgggt gggtgtcatg ggtgtcccca cccactcctc   1123

 agtgtttgtg gagtcgagga gccaacccca gcctcctgcc aggatcacct cggcggtcac   1183

 actccagcca aatagtgttc tcggggtggt ggctgggcag cgcctatgtt tctctggaga   1243

 ttcctgcaac ctcaagagac ttcccaggcg ctcaggcctg gatcttgctc ctctgtgagg   1303

 aacaagggtg cctaataaat acatttctgc tttattaaaa aaaaaaaa                1351




      <210> 94
      <211> 926
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(579)

      <400> 94
 cgcttgtgaa actggaaggc tgcc   atg gct agc cca gcc gcc tcc tcg gtg      51
                              Met Ala Ser Pro Ala Ala Ser Ser Val
                                1               5

 cga cca ccg agg ccc aag aaa gag ccg cag acg ctc gtc atc ccc aag       99
 Arg Pro Pro Arg Pro Lys Lys Glu Pro Gln Thr Leu Val Ile Pro Lys
  10                  15                  20                  25

 aat gcg gcg gag gag cag aag ctc aag ctg gag cgg ctc atg aag aac      147
 Asn Ala Ala Glu Glu Gln Lys Leu Lys Leu Glu Arg Leu Met Lys Asn
                  30                  35                  40

 ccg gac aaa gca gtt cca att cca gag aaa atg agt gaa tgg gca cct      195
 Pro Asp Lys Ala Val Pro Ile Pro Glu Lys Met Ser Glu Trp Ala Pro
              45                  50                  55

 cga cct ccc cca gaa ttt gtc cga gat gtc atg ggt tca agt gct ggg      243
 Arg Pro Pro Pro Glu Phe Val Arg Asp Val Met Gly Ser Ser Ala Gly
          60                  65                  70

 gcc ggc agt gga gag ttc cac gtg tac aga cat ctg cgc cgg aga gaa      291
 Ala Gly Ser Gly Glu Phe His Val Tyr Arg His Leu Arg Arg Arg Glu
      75                  80                  85

 tat cag cga cag gac tac atg gat gcc atg gct gag aag caa aaa ttg      339
 Tyr Gln Arg Gln Asp Tyr Met Asp Ala Met Ala Glu Lys Gln Lys Leu
  90                  95                 100                 105

 gat gca gag ttt cag aaa aga ctg gaa aag aat aaa att gct gca gag      387
 Asp Ala Glu Phe Gln Lys Arg Leu Glu Lys Asn Lys Ile Ala Ala Glu
                 110                 115                 120

 gag cag acc gca aag cgc cgg aag aag cgc cag aag tta aaa gag aag      435
 Glu Gln Thr Ala Lys Arg Arg Lys Lys Arg Gln Lys Leu Lys Glu Lys
             125                 130                 135

 aaa tta ctg gca aag aag atg aaa ctt gaa cag aag aaa caa gaa gga      483
 Lys Leu Leu Ala Lys Lys Met Lys Leu Glu Gln Lys Lys Gln Glu Gly
         140                 145                 150

 ccc ggt cag ccc aag gag cag ggg tcc agc agc tct gcg gag gca tct      531
 Pro Gly Gln Pro Lys Glu Gln Gly Ser Ser Ser Ser Ala Glu Ala Ser
     155                 160                 165

 gga aca gag gag gag gag gaa gtg ccc agt ttc acc atg ggg cga tga      579
 Gly Thr Glu Glu Glu Glu Glu Val Pro Ser Phe Thr Met Gly Arg 
 170                 175                 180

 caatgtttgc cacagcctct gcctggaacc tggctcgtgc tgtgaccaga agggaaaggc    639

 ggctgtttgg ctctttctcc cccgcaagga cccgctgacc cgctggatgg agagcaaagg    699

 agacccctcc cgagccgctc acagtcctgt atttggcagg tttgggagcc tgaggggcca    759

 tctccctgac actcagaggc actgccttgc agacaccatc cgtgctcctg gtaaaggggg    819

 acagagagcc tcaccttgcc acatatttga acagtgatga gtttggggct ggtttctggg    879

 aagggaacgt ttatttagta aagagcagaa cacccttaaa aaaaaaa                  926




      <210> 95
      <211> 938
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (98)..(562)

      <400> 95
 atttggccct cgagcaagaa gttcggcacg aggcggcacg aggcgaggcc cgggtgagaa     60

 acgggggaga cgcgaggggc ggacgttgtg gaggaag atg gct gcc gcc tgg ggg     115
                                          Met Ala Ala Ala Trp Gly
                                            1               5

 tcg tcc cta acg gcc gcg acg cag aga gcg gtc act ccc tgg ccg agg      163
 Ser Ser Leu Thr Ala Ala Thr Gln Arg Ala Val Thr Pro Trp Pro Arg
              10                  15                  20

 ggc agg ctc ctc acg gcc tcc ctg gga ccc cag gcg cgt cgg gag gcg      211
 Gly Arg Leu Leu Thr Ala Ser Leu Gly Pro Gln Ala Arg Arg Glu Ala
          25                  30                  35

 tcg tcc tcc agc ccc gag gcc ggc gaa ggg cag atc cgc ctc aca gac      259
 Ser Ser Ser Ser Pro Glu Ala Gly Glu Gly Gln Ile Arg Leu Thr Asp
      40                  45                  50

 agt tgc gtc cag agg ctt ttg gaa atc acc gaa ggg tca gaa ttc ctc      307
 Ser Cys Val Gln Arg Leu Leu Glu Ile Thr Glu Gly Ser Glu Phe Leu
  55                  60                  65                  70

 agg ctg caa gtg gag gga ggt gga tgc tcc gga ttc caa tac aaa ttt      355
 Arg Leu Gln Val Glu Gly Gly Gly Cys Ser Gly Phe Gln Tyr Lys Phe
                  75                  80                  85

 tca ctg gat aca gtt atc aac ccc gac gac agg gta ttt gaa cag ggt      403
 Ser Leu Asp Thr Val Ile Asn Pro Asp Asp Arg Val Phe Glu Gln Gly
              90                  95                 100

 ggg gca aga gtg gtg gtt gac tct gat agc ttg gcc ttc gtg aaa ggg      451
 Gly Ala Arg Val Val Val Asp Ser Asp Ser Leu Ala Phe Val Lys Gly
         105                 110                 115

 gcc cag gtg gac ttc agc caa gaa ctg atc cga agc tca ttt caa gtg      499
 Ala Gln Val Asp Phe Ser Gln Glu Leu Ile Arg Ser Ser Phe Gln Val
     120                 125                 130

 ttg aac aat cct caa gca cag caa ggc tgc tcc tgt ggg tca tct ttc      547
 Leu Asn Asn Pro Gln Ala Gln Gln Gly Cys Ser Cys Gly Ser Ser Phe
 135                 140                 145                 150

 tct atc aaa ctt tga tgtgatgact ggtgactctg ggattgtcac cagttgtacc      602
 Ser Ile Lys Leu 


 aatttgaaga acctggaatt agtagaattc tagaagttta cttctaatca tgtccctctc    662

 aattttattt cccgcagtcc aggagtgtta tgttttgcca ctattatttt cagaatgtga    722

 agattttact cttggcttaa tttttccctc cactcagtgc taaggctgag cctccagatg    782

 ctgttacctc agatttaatc actggttgaa actccgtata atctgtagag cctccatggc    842

 tctaaaattt ggaattaact tctcttgcct taagagctgc ttgtacatat gtggatagct    902

 atgtataaaa gcttcatttt aaagaaaaaa aaaaaa                              938




      <210> 96
      <211> 1878
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (379)..(903)

      <400> 96
 cgtaccggtc cggaattccc gggtcgatcc acgcgtccgg cataccgact gggggatgcc     60

 agctcatatc tctcgtatac tgtcaccgac gcgcaatata ctggccggcg tgttacaacg    120

 tcccgacggt gacaaccctg actttacccc ggttaggcgg ggcgatgatt atcctaccgg    180

 gggccctggt gaccaacttg ctgcggtttt tgttcctggg gctgagtgcc ctcgcgcccc    240

 cctcgcgggc ccagctgcaa ctgcgacttg cccgccaacc ggttgcaggc ggtggaggga    300

 ggggaagtgg tgcttccagc gtggtacacc ttgcacgggg aggtgtcttc atcccagcca    360

 tgggaggtgc cctttgtg  atg tgg ttc ttc aaa cag aaa gaa aag gag gat     411
                      Met Trp Phe Phe Lys Gln Lys Glu Lys Glu Asp
                        1               5                  10

 cag gtg ttg tcc tac atc aat ggg gtc aca aca agc aaa cct gga gta      459
 Gln Val Leu Ser Tyr Ile Asn Gly Val Thr Thr Ser Lys Pro Gly Val
              15                  20                  25

 tcc ttg gtc tac tcc atg ccc tcc cgg aac ctg tcc ctg cgg ctg gag      507
 Ser Leu Val Tyr Ser Met Pro Ser Arg Asn Leu Ser Leu Arg Leu Glu
          30                  35                  40

 ggt ctc cag gag aaa gac tct ggc ccc tac agc tgc tcc gtg aat gtg      555
 Gly Leu Gln Glu Lys Asp Ser Gly Pro Tyr Ser Cys Ser Val Asn Val
      45                  50                  55

 caa gac aaa caa ggc aaa tct agg ggc cac agc atc aaa acc tta gaa      603
 Gln Asp Lys Gln Gly Lys Ser Arg Gly His Ser Ile Lys Thr Leu Glu
  60                  65                  70                  75

 ctc aat gta ctg gtt cct cca gct cct cca tcc tgc cgt ctc cag ggt      651
 Leu Asn Val Leu Val Pro Pro Ala Pro Pro Ser Cys Arg Leu Gln Gly
                  80                  85                  90

 gtg ccc cat gtg ggg gca aac gtg acc ctg agc tgc cag tct cca agg      699
 Val Pro His Val Gly Ala Asn Val Thr Leu Ser Cys Gln Ser Pro Arg
              95                 100                 105

 agt aag ccc gct gtc caa tac cag tgg gat cgg cag ctt cca tcc ttc      747
 Ser Lys Pro Ala Val Gln Tyr Gln Trp Asp Arg Gln Leu Pro Ser Phe
         110                 115                 120

 cag act ttc ttt gca cca gca tta gat gtc atc cgt ggg tct tta agc      795
 Gln Thr Phe Phe Ala Pro Ala Leu Asp Val Ile Arg Gly Ser Leu Ser
     125                 130                 135

 ctc acc aac ctt tcc tct tcc atg gct gga gtc tat gtc tgc aag gcc      843
 Leu Thr Asn Leu Ser Ser Ser Met Ala Gly Val Tyr Val Cys Lys Ala
 140                 145                 150                 155

 cac aat gag gtg ggc act gcc caa tgt aat gtg acg ctg gaa gtg agc      891
 His Asn Glu Val Gly Thr Ala Gln Cys Asn Val Thr Leu Glu Val Ser
                 160                 165                 170

 aca ggt cag tga ggg ggcctggagc tgcagtggtt gctggagctg ttgtgggtac      946
 Thr Gly Gln 


 cctggttgga ctggggttgc tggctgggct ggtcctcttg taccaccgcc ggggcaaggc   1006

 cctggaggag ccagccaatg atatcaagga ggatgccatt gctccccgga ccctgccctg   1066

 gcccaagagc tcagacacaa tctccaagaa tgggaccctt tcctctgtca cctccgcacg   1126

 agccctccgg ccaccccatg gccctcccag gcctggtgca ttgaccccca cgcccagtct   1186

 ctccagccag gccctgccct caccaagact gcccacgaca gatggggccc acccacaacc   1246

 aatatccccc atccctggtg gggtttcttc ctctggcttg agccgcatgg gtgctgtgcc   1306

 tgtgatggtg cctgcccaga gtcaagctgg ctctctggta tgatgacccc accactcatt   1366

 ggctaaagga tttggggtct ctccttccta taggggtcac ctctagcaca gaggcctgag   1426

 tcatgggaaa gagtcacact cctgaccctt agtactctgc ccccacctct ctttactgtg   1486

 ggaaaaccat ctcagtaaga cctaagtgtc caggagacag aaggagaaga ggaagtggat   1546

 ctggaattgg gaggagcctc cacccacccc tgactcctcc ttatgaagcc agctgctgaa   1606

 attagctact caccaagagt gaggggcaga gacttccagt cactgagtct cccaggcccc   1666

 cttgatctgt accccacccc tatctaacac cacccttggc tcccactcca gctccctgta   1726

 ttgatataac ctgtcaggct ggcttggtta ggttttactg gggcagagga tagggaatct   1786

 cttattaaaa ctaacatgaa atatgtgttg ttttcatttg caaatttaaa taaagataca   1846

 taatgtttgt atgagataag aaaaaaaaaa aa                                 1878




      <210> 97
      <211> 896
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(588)

      <400> 97
  atg gcg ccg gcc gcg tcc agg ctg cgg gcc gaa gcc ggg ctc ggg gcg      48
  Met Ala Pro Ala Ala Ser Arg Leu Arg Ala Glu Ala Gly Leu Gly Ala
    1               5                  10                  15

 ctg ccg cgg cgg gcg ctc gcc cag tac ttg ctc ttc ctg cgg ctc tac       96
 Leu Pro Arg Arg Ala Leu Ala Gln Tyr Leu Leu Phe Leu Arg Leu Tyr
              20                  25                  30

 ccg gtg ctc acc aag gcg gcc acc agt ggc att ttg tca gca ctt ggg      144
 Pro Val Leu Thr Lys Ala Ala Thr Ser Gly Ile Leu Ser Ala Leu Gly
          35                  40                  45

 aac ttc ctg gcc cag atg att gag aag aag cgg aaa aaa gaa aac tct      192
 Asn Phe Leu Ala Gln Met Ile Glu Lys Lys Arg Lys Lys Glu Asn Ser
      50                  55                  60

 aga agt ctg gat gtc ggt ggg cct ctg aga tat gcc gtt tac ggg ttc      240
 Arg Ser Leu Asp Val Gly Gly Pro Leu Arg Tyr Ala Val Tyr Gly Phe
  65                  70                  75                  80

 ttc ttc aca ggg ccg ctg agt cac ttc ttc tac ttc ttc atg gaa cat      288
 Phe Phe Thr Gly Pro Leu Ser His Phe Phe Tyr Phe Phe Met Glu His
                  85                  90                  95

 tgg atc cct cct gag gtc ccc ctg gca ggg ctc agg agg ctt ctc ctg      336
 Trp Ile Pro Pro Glu Val Pro Leu Ala Gly Leu Arg Arg Leu Leu Leu
             100                 105                 110

 gac cgc ctc gtc ttt gca ccg gcc ttc ctc atg ttg ttc ttc ctc atc      384
 Asp Arg Leu Val Phe Ala Pro Ala Phe Leu Met Leu Phe Phe Leu Ile
         115                 120                 125

 atg aac ttt ctg gag ggg aaa gac gcc tca gcc ttc gcc gcc aag atg      432
 Met Asn Phe Leu Glu Gly Lys Asp Ala Ser Ala Phe Ala Ala Lys Met
     130                 135                 140

 agg ggg ggc ttc tgg ccg gcg ctg agg atg aac tgg cgg gtg tgg acg      480
 Arg Gly Gly Phe Trp Pro Ala Leu Arg Met Asn Trp Arg Val Trp Thr
 145                 150                 155                 160

 cca cta cag ttc atc aac atc aac tac gtc cct ctg aag ttc cgg gtg      528
 Pro Leu Gln Phe Ile Asn Ile Asn Tyr Val Pro Leu Lys Phe Arg Val
                 165                 170                 175

 ctc ttc gcc aac ctg gca gct ctg ttc tgg tat gcc tac ctg gcc tcc      576
 Leu Phe Ala Asn Leu Ala Ala Leu Phe Trp Tyr Ala Tyr Leu Ala Ser
             180                 185                 190

 ttg ggg aag tga cga ccgctgggag aacatcaggt gcactgtgga cgtgggtctg      631
 Leu Gly Lys 
         195

 ggggtctcac ccgcccagcg agagcagaac caatccagtc aggatgtcac tgactctaaa    691

 tcaggtgatt caagatgccc aaaaatgatg gatagagaaa cagaaatctc tgaatgtcag    751

 aaccctgtct tttaaaaagg cagtcgctgc cttcaggtgg tgctgcccca gaaacttaaa    811

 atttagtcga ggcagtttca attgttactg tggaccgaat taggatcaca ataaacgata    871

 atgcaggttc ttcaaaaaaa aaaaa                                          896




      <210> 98
      <211> 1888
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (346)..(1098)

      <400> 98
 ccacgcgtcg cacggtcaca ctgcagcatc agcacccggt gaatgtggtt ctcttcccat     60

 gtcagaattt tgtgagctcc acacgggcag ggttgcatct gtttgattct ctgattgatg    120

 ctaagcccca tgtccctggc acaggatggc tgcttggcag tagggagtgg atgaaccagt    180

 agtacccagg gctgccaggc agggccctgc aggggacaga cccaagggct gatatgggga    240

 cacctgctga ggggggaatt taccacggta agggcagggc tgggaggctg ggcagccagt    300

 ttcaccctcg cacaggctgc ctggcaagac cagcggctgg aggtg    atg tcc tca     354
                                                      Met Ser Ser
                                                        1

 gta gag aac ggt ggc cac tgg aaa cgt gtg gcc aga agg gga aac gct      402
 Val Glu Asn Gly Gly His Trp Lys Arg Val Ala Arg Arg Gly Asn Ala
       5                  10                  15

 cgg gcc tct ggt ggg ggc cag cct ggg gtg ggg tcg gcc agg gtc agc      450
 Arg Ala Ser Gly Gly Gly Gln Pro Gly Val Gly Ser Ala Arg Val Ser
  20                  25                  30                  35

 tgc ctt tcc ttc atg ctg ggg agg aga tgt tgt gtg cat gtg aga aag      498
 Cys Leu Ser Phe Met Leu Gly Arg Arg Cys Cys Val His Val Arg Lys
                  40                  45                  50

 cat ttg ata gca tgc caa aag ttt cct cca tta tgt gcg tgt caa gtg      546
 His Leu Ile Ala Cys Gln Lys Phe Pro Pro Leu Cys Ala Cys Gln Val
              55                  60                  65

 ttt gac cag gtc aga act ctt gtt cta tgc gaa tgt gct cac gca gac      594
 Phe Asp Gln Val Arg Thr Leu Val Leu Cys Glu Cys Ala His Ala Asp
          70                  75                  80

 aga agc gga ggg gct ccg tcg ctc tgc cct cac gcc gct gaa ccg cga      642
 Arg Ser Gly Gly Ala Pro Ser Leu Cys Pro His Ala Ala Glu Pro Arg
      85                  90                  95

 ggg tct ccc gct cct cag gct tgc ggc tcg gcc gcg aag tgt gtc agg      690
 Gly Ser Pro Ala Pro Gln Ala Cys Gly Ser Ala Ala Lys Cys Val Arg
 100                 105                 110                 115

 tgt gca tcc tgg gtg ctc ctt tgt gct ctg tcc tac ggt gac aca ggc      738
 Cys Ala Ser Trp Val Leu Leu Cys Ala Leu Ser Tyr Gly Asp Thr Gly
                 120                 125                 130

 ggc gtg ggg tta gac agg tac cgg tca gac tac ggt gac aca ggc ggc      786
 Gly Val Gly Leu Asp Arg Tyr Arg Ser Asp Tyr Gly Asp Thr Gly Gly
             135                 140                 145

 gtg cgg tta gac agg tac cgg tca gat tac ggt ggc aca ggc ggc gtg      834
 Val Arg Leu Asp Arg Tyr Arg Ser Asp Tyr Gly Gly Thr Gly Gly Val
         150                 155                 160

 ggg tta gac agg tac cgg tca gat tac ggt ggc aca ggc ggc gtg ggg      882
 Gly Leu Asp Arg Tyr Arg Ser Asp Tyr Gly Gly Thr Gly Gly Val Gly
     165                 170                 175

 tta gac agg tac cgg tca gat tac ggt ggc aca ggc ggc gtg ggg tta      930
 Leu Asp Arg Tyr Arg Ser Asp Tyr Gly Gly Thr Gly Gly Val Gly Leu
 180                 185                 190                 195

 gac agg tac cgg tca gat tac ggt gac aca ggc ggc gtg ggg tta gac      978
 Asp Arg Tyr Arg Ser Asp Tyr Gly Asp Thr Gly Gly Val Gly Leu Asp
                 200                 205                 210

 agg tac cgg tca gat tac ggt ggc aca ggc tgc gtg ggg tta gac agg     1026
 Arg Tyr Arg Ser Asp Tyr Gly Gly Thr Gly Cys Val Gly Leu Asp Arg
             215                 220                 225

 tac cgg tca gat tac ggt ggc aca ggc ggc gtg ggg tta gac agg tac     1074
 Tyr Arg Ser Asp Tyr Gly Gly Thr Gly Gly Val Gly Leu Asp Arg Tyr
         230                 235                 240

 tgg tca gat gca cgg gct ccc taa acccctgctg tggcttcggc agtaaagaca    1128
 Trp Ser Asp Ala Arg Ala Pro 
     245                 250

 ggacgcaccc atgtcacaag aggagcacag gcaggggtgt tggtgttggg gcagccctca   1188

 gggtctccag accccagccc cactcacaca gcagcctagg aaggaagggc agagtcccag   1248

 gtgtcagctg gtgggtctcc caggagctgc ccctccctgg aagtcacagg acaggaatga   1308

 cagatcaggg aactgcagga agctgccacc tctggggtca gaatatgccc agcctgcggg   1368

 ggctctctat cggggtcttc gagagccaga cagcctgcct tgtgctgcat acctggcttt   1428

 gctctgtgca gaacccagca cacgtgattt tgtgtgacat gccagcagcc tggctcccag   1488

 gacaggaggc ctgccctggg ggaggggctg caggaggagg gggggcaggc acccatgagt   1548

 ctgtccagcc ttgtcacaga tgcatcgccc agcctgcggt cctgatttca gctcacctca   1608

 gagtaaatca gaataaactg cacccagact ttcacgaatg catgttgacg ctttcagttc   1668

 acccctttct ttgctaactt tcttcctatt ttcttctaat gcgagagctt attaattcca   1728

 tatttatcat tttgaataac ttttctcctt tttagtaaca aaatgtactt cactcttagt   1788

 aaaatgtatt tactatttta gtaacaaaaa tatacttgcc taatcatgtt taaaatatag   1848

 tgatgtgaaa aattcaaaaa aaaaaaaaaa aaaaaaaaaa                         1888




      <210> 99
      <211> 1892
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(1797)

      <400> 99
 ggagaagtag gccaa atg gga cct aca ggc cct cga gga cca gtg gga att      51
                  Met Gly Pro Thr Gly Pro Arg Gly Pro Val Gly Ile
                    1               5                  10

 gga gta caa ggt cca aag ggt gac gaa ggc aag aaa ggg agc aaa gga       99
 Gly Val Gln Gly Pro Lys Gly Asp Glu Gly Lys Lys Gly Ser Lys Gly
          15                  20                  25

 aat caa gga cag agg gga ctt cca ggg ccc gaa gga cca aag ggt gaa      147
 Asn Gln Gly Gln Arg Gly Leu Pro Gly Pro Glu Gly Pro Lys Gly Glu
      30                  35                  40

 ccg ggc att atg ggc cct ttt gga atg cct gga aca tca att cct gga      195
 Pro Gly Ile Met Gly Pro Phe Gly Met Pro Gly Thr Ser Ile Pro Gly
  45                  50                  55                  60

 cca cct ggg cca aag gga gat aga gga gga cct ggg ata cct gga ttt      243
 Pro Pro Gly Pro Lys Gly Asp Arg Gly Gly Pro Gly Ile Pro Gly Phe
                  65                  70                  75

 aag gga gaa cct gga ctt tct att cga gga cca aag ggt gtc caa ggc      291
 Lys Gly Glu Pro Gly Leu Ser Ile Arg Gly Pro Lys Gly Val Gln Gly
              80                  85                  90

 cct cgg gga cca gtg ggt gct cca gga ctc aaa ggt gat ggc tat cct      339
 Pro Arg Gly Pro Val Gly Ala Pro Gly Leu Lys Gly Asp Gly Tyr Pro
          95                 100                 105

 ggt gtg cct gga cct cgt gga tta cca gga ccc cct ggg ccg atg ggt      387
 Gly Val Pro Gly Pro Arg Gly Leu Pro Gly Pro Pro Gly Pro Met Gly
     110                 115                 120

 tta cgt gga gtg gga gac act gga gca aag gga gag cct ggg gtc aga      435
 Leu Arg Gly Val Gly Asp Thr Gly Ala Lys Gly Glu Pro Gly Val Arg
 125                 130                 135                 140

 ggc cct cca ggt cct tct ggg cct cgg ggc gta gga acc caa ggg cca      483
 Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Val Gly Thr Gln Gly Pro
                 145                 150                 155

 aag ggt gat act ggg cag aaa ggc ttg cct ggc cct cct ggc ccc cct      531
 Lys Gly Asp Thr Gly Gln Lys Gly Leu Pro Gly Pro Pro Gly Pro Pro
             160                 165                 170

 ggc tat gga tca cag gga att aaa ggg gaa caa gga cca caa ggc ttc      579
 Gly Tyr Gly Ser Gln Gly Ile Lys Gly Glu Gln Gly Pro Gln Gly Phe
         175                 180                 185

 cca ggc cca aag ggc aca atg ggc cat ggc ctc cca ggc cag aag gga      627
 Pro Gly Pro Lys Gly Thr Met Gly His Gly Leu Pro Gly Gln Lys Gly
     190                 195                 200

 gag cac gga gaa cgg ggc gat gtg gga aag aaa ggt gat aaa gga gaa      675
 Glu His Gly Glu Arg Gly Asp Val Gly Lys Lys Gly Asp Lys Gly Glu
 205                 210                 215                 220

 att gga gag cct gga tct cca gga aaa cag ggt tta caa gga ccc aaa      723
 Ile Gly Glu Pro Gly Ser Pro Gly Lys Gln Gly Leu Gln Gly Pro Lys
                 225                 230                 235

 gga gac cta gga ctt aca aaa gaa gaa att atc aaa ctt att aca gaa      771
 Gly Asp Leu Gly Leu Thr Lys Glu Glu Ile Ile Lys Leu Ile Thr Glu
             240                 245                 250

 ata tgt ggt tgt ggg ccc aaa tgc aaa gag act cca cta gag ctg gtg      819
 Ile Cys Gly Cys Gly Pro Lys Cys Lys Glu Thr Pro Leu Glu Leu Val
         255                 260                 265

 ttt gtg atc gac agc tca gaa agc gtg ggg cca gag aac ttt cag atc      867
 Phe Val Ile Asp Ser Ser Glu Ser Val Gly Pro Glu Asn Phe Gln Ile
     270                 275                 280

 att aaa aat ttt gtg aag act atg gct gac cgg gtt gct ctg gac ctt      915
 Ile Lys Asn Phe Val Lys Thr Met Ala Asp Arg Val Ala Leu Asp Leu
 285                 290                 295                 300

 gcc acg gcc cgc ata ggc ata atc aac tat agc cat aag gtg gag aag      963
 Ala Thr Ala Arg Ile Gly Ile Ile Asn Tyr Ser His Lys Val Glu Lys
                 305                 310                 315

 gtg gct aat ttg aag cag ttc tcc agc aag gat gac ttc aag ttg gct     1011
 Val Ala Asn Leu Lys Gln Phe Ser Ser Lys Asp Asp Phe Lys Leu Ala
             320                 325                 330

 gtg gac aac atg cag tat ctg ggg gaa ggc aca tac aca gcc act gct     1059
 Val Asp Asn Met Gln Tyr Leu Gly Glu Gly Thr Tyr Thr Ala Thr Ala
         335                 340                 345

 ctg caa gca gcc aac gac atg ttt gaa gat gca agg cca ggt gta aaa     1107
 Leu Gln Ala Ala Asn Asp Met Phe Glu Asp Ala Arg Pro Gly Val Lys
     350                 355                 360

 aaa gtg gcc ttg gtc atc act gat gga cag aca gat tct cgt gat aaa     1155
 Lys Val Ala Leu Val Ile Thr Asp Gly Gln Thr Asp Ser Arg Asp Lys
 365                 370                 375                 380

 gag aaa ctg aca gag gtg gtg aag aat gcc agt gac acc aat gtg gag     1203
 Glu Lys Leu Thr Glu Val Val Lys Asn Ala Ser Asp Thr Asn Val Glu
                 385                 390                 395

 ata ttt gtg ata ggg gtg gtg aag aaa aat gat ccc aac ttt gaa ata     1251
 Ile Phe Val Ile Gly Val Val Lys Lys Asn Asp Pro Asn Phe Glu Ile
             400                 405                 410

 ttc cac aaa gaa atg aat cta att gct act gac cca gag cat gtt tac     1299
 Phe His Lys Glu Met Asn Leu Ile Ala Thr Asp Pro Glu His Val Tyr
         415                 420                 425

 cag ttt gat gat ttc ttt acc ctg caa gac acc ctg aag caa aaa ttg     1347
 Gln Phe Asp Asp Phe Phe Thr Leu Gln Asp Thr Leu Lys Gln Lys Leu
     430                 435                 440

 ttt caa aaa att tgt gag gat ttt gat tcc tat ctc gtt caa att ttt     1395
 Phe Gln Lys Ile Cys Glu Asp Phe Asp Ser Tyr Leu Val Gln Ile Phe
 445                 450                 455                 460

 ggt tca tcg tca cct caa cct gga ttt ggg atg tca ggg gaa gaa ctc     1443
 Gly Ser Ser Ser Pro Gln Pro Gly Phe Gly Met Ser Gly Glu Glu Leu
                 465                 470                 475

 agt gaa tct act cca gag cct caa aaa gaa att tct gag tca ttg agt     1491
 Ser Glu Ser Thr Pro Glu Pro Gln Lys Glu Ile Ser Glu Ser Leu Ser
             480                 485                 490

 gtc acc aga gac cag gat gaa gat gat aag gct cca gag cca acg tgg     1539
 Val Thr Arg Asp Gln Asp Glu Asp Asp Lys Ala Pro Glu Pro Thr Trp
         495                 500                 505

 gct gat gat ctg cct gcc act acc tca tct gag gcc acc acc acc ccc     1587
 Ala Asp Asp Leu Pro Ala Thr Thr Ser Ser Glu Ala Thr Thr Thr Pro
     510                 515                 520

 agg cca ctg ctc agc acc cct gtg gat ggg gca gag gat cct aga tgt     1635
 Arg Pro Leu Leu Ser Thr Pro Val Asp Gly Ala Glu Asp Pro Arg Cys
 525                 530                 535                 540

 ttg gaa gcc ttg aag cct gga aac tgt ggt gaa tat gtg gtt cga tgg     1683
 Leu Glu Ala Leu Lys Pro Gly Asn Cys Gly Glu Tyr Val Val Arg Trp
                 545                 550                 555

 tat tat gac aaa cag gtc aac tct tgt gcc cga ttt tgg ttc agt ggc     1731
 Tyr Tyr Asp Lys Gln Val Asn Ser Cys Ala Arg Phe Trp Phe Ser Gly
             560                 565                 570

 tgt aat ggc tca gga aat aga ttc aac agt gaa aag gaa tgt caa gaa     1779
 Cys Asn Gly Ser Gly Asn Arg Phe Asn Ser Glu Lys Glu Cys Gln Glu
         575                 580                 585

 acc tgc att caa gga tga gcaagt aaattggcct gtctctatca aaagcataga     1833
 Thr Cys Ile Gln Gly 
     590

 actccctaat ttccacatat tcacccaata caaatacagc actataaaaa aaaaaaaaa    1892




      <210> 100
      <211> 933
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(933)

      <400> 100
  atg agg agg aca gct ttg atc ctg ggc tct gga ctt ctc tca ttt gtg      48
  Met Arg Arg Thr Ala Leu Ile Leu Gly Ser Gly Leu Leu Ser Phe Val
    1               5                  10                  15

 gcc ttc tgg aac tca gtg aca tgg cat ctt cag aga ttt tgg ggt gct       96
 Ala Phe Trp Asn Ser Val Thr Trp His Leu Gln Arg Phe Trp Gly Ala
              20                  25                  30

 tct ggc tac ttt tgg caa gcc cag tgg gag agg ctg ctg act aca ttt      144
 Ser Gly Tyr Phe Trp Gln Ala Gln Trp Glu Arg Leu Leu Thr Thr Phe
          35                  40                  45

 gaa ggg aag gag tgg atc ctc ttc ttt ata ggt gcc atc caa gtg cct      192
 Glu Gly Lys Glu Trp Ile Leu Phe Phe Ile Gly Ala Ile Gln Val Pro
      50                  55                  60

 tgt ctc ttc ttc tgg agc ttc aat ggg ctt cta ttg gtg gtt gac aca      240
 Cys Leu Phe Phe Trp Ser Phe Asn Gly Leu Leu Leu Val Val Asp Thr
  65                  70                  75                  80

 aca gga aaa cct aac ttc atc tct cgc tac cga att cag gtc ggc aag      288
 Thr Gly Lys Pro Asn Phe Ile Ser Arg Tyr Arg Ile Gln Val Gly Lys
                  85                  90                  95

 aat gaa cct gtg gat cct gtg aaa ctg cgc cag tct atc cgc aca gtt      336
 Asn Glu Pro Val Asp Pro Val Lys Leu Arg Gln Ser Ile Arg Thr Val
             100                 105                 110

 ctt ttc aac cag tgc atg ata tct ttc ccc atg gtg gtc ttc ctc tat      384
 Leu Phe Asn Gln Cys Met Ile Ser Phe Pro Met Val Val Phe Leu Tyr
         115                 120                 125

 ccc ttc ctc aaa tgg tgg aga gac ccc tgc cgc cgt gag cta ccc acc      432
 Pro Phe Leu Lys Trp Trp Arg Asp Pro Cys Arg Arg Glu Leu Pro Thr
     130                 135                 140

 ttc cac tgg ttc ctc ctg gag ctg gcc atc ttc acg ctg atc gag gaa      480
 Phe His Trp Phe Leu Leu Glu Leu Ala Ile Phe Thr Leu Ile Glu Glu
 145                 150                 155                 160

 gtc ttg ttc tac tat tca cac cgg ctc ctt cac cac cca aca ttc tac      528
 Val Leu Phe Tyr Tyr Ser His Arg Leu Leu His His Pro Thr Phe Tyr
                 165                 170                 175

 aag aaa atc cac aag aaa cac cat gag tgg aca gct ccc att ggc gtg      576
 Lys Lys Ile His Lys Lys His His Glu Trp Thr Ala Pro Ile Gly Val
             180                 185                 190

 atc tct ctc tat gcc cac cct ata gag cat gca gtc tcc aac atg cta      624
 Ile Ser Leu Tyr Ala His Pro Ile Glu His Ala Val Ser Asn Met Leu
         195                 200                 205

 ccg gtg ata gtg ggc cca tta gta atg ggc tcc cac ttg tcc tcc atc      672
 Pro Val Ile Val Gly Pro Leu Val Met Gly Ser His Leu Ser Ser Ile
     210                 215                 220

 acc atg tgg ttt tcc ttg gcc ctc atc atc acc acc atc tcc cac tgt      720
 Thr Met Trp Phe Ser Leu Ala Leu Ile Ile Thr Thr Ile Ser His Cys
 225                 230                 235                 240

 ggc tac cac ctt ccc ttc ctg cct tcg cct gaa ttc cac gac tac cac      768
 Gly Tyr His Leu Pro Phe Leu Pro Ser Pro Glu Phe His Asp Tyr His
                 245                 250                 255

 cat ctc aag ttc aac cag tgc tat ggg gtg ctg ggt gtg ctg gac cac      816
 His Leu Lys Phe Asn Gln Cys Tyr Gly Val Leu Gly Val Leu Asp His
             260                 265                 270

 ctc cat ggg act gac acc atg ttc aag cag acc aag gcc tac gag aga      864
 Leu His Gly Thr Asp Thr Met Phe Lys Gln Thr Lys Ala Tyr Glu Arg
         275                 280                 285

 cat gtc ctc ctg ctg ggc ttc acc ccg ctc tct gag agc atc cca gac      912
 His Val Leu Leu Leu Gly Phe Thr Pro Leu Ser Glu Ser Ile Pro Asp
     290                 295                 300

 tcc cca aag agg atg gag tga                                          933
 Ser Pro Lys Arg Met Glu 
 305                 310





      <210> 101
      <211> 6571
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1223)..(6304)

      <400> 101
 ctcctgaatc aattttgcat gagaggattg aacaagagat tgagatggaa atgaaagaat     60

 tattctctga gggggaatct gaacattcag aaagggatac acgtgacgcc ttttcagatt    120

 ctgaagacat agaccacaaa tccatggctg ctaaaagata tgcaagtaga atatcatcta    180

 caagctcctg gcctgaatat tttaagcctt cttttaccca gaaacttaca tttaaatatg    240

 ttttagaggg tgaaccggtt gtttttacat gtagattaat tgcctgtcca actccagaaa    300

 tgacttggtt tcataacaat cggcccatcc caacaggtct tcgtcggatt ataaaagctg    360

 agagtgattt acaccatcac tcttccagct tagagattaa aagggtccaa gacagagatt    420

 ctggaagtta taggttacta gcaattaata gtgaagggtc tgcagaatca actgcatcat    480

 tgcttgttat ccaaaagggc aagatgagaa atatttagaa tttctgaaaa gagcagaacg    540

 gacacatgaa aatgtggagg ctttagttga aaggggagaa gataggataa aggttgacct    600

 gaggtttact ggctctccct ttaacaaaaa acaagatgtg gaacaaaagg gaatgatgag    660

 aactatacat tttaagacaa tgagttctgc caagaaaaca gattacatgt atgatgaaga    720

 atatttagaa agtaaatctg acataagagg ttggcttaat gtaggtgaaa gtttcctgga    780

 caaggagacc aaagtgaagt tgcaacgttt aagggaggct agaaaaacat taatggagaa    840

 aaagaaatta tctcttttag atacgtcttc tgaaataagc tcaagaactt tgagaagtga    900

 agctagtgat aaagatattc tgttctctag agaggacatg aaaatcagat ctatgtctga    960

 tctagctgaa agttataagg tagatcattc agctgagagt attgtgcaaa atccacatgc   1020

 cctttctaat caaatggatc aaaatataga atctgaggaa cttcccacaa gctttcaaac   1080

 tattgttgat gaagaaattt tccagactga aataagaatg agccaagaag cactggtaaa   1140

 ggaaagtcta ccaaaagacc atttatatgg tgaaattcta gtaaatgaaa atacccaagc   1200

 aagaggacag ctggaagaaa tt atg gcc aat act aca att gga gag tca tcc    1252
                          Met Ala Asn Thr Thr Ile Gly Glu Ser Ser
                            1               5                  10

 aca tat atc act aat gta tgt gag aag gag gaa gta tat gag act cct     1300
 Thr Tyr Ile Thr Asn Val Cys Glu Lys Glu Glu Val Tyr Glu Thr Pro
                  15                  20                  25

 gaa aat gtg tct caa gct att aca cca cat gcc agc gaa tct ttt ggt     1348
 Glu Asn Val Ser Gln Ala Ile Thr Pro His Ala Ser Glu Ser Phe Gly
              30                  35                  40

 aca ctt gta aat gtt gaa gaa agt gaa gaa ata gct agt gaa aga ata     1396
 Thr Leu Val Asn Val Glu Glu Ser Glu Glu Ile Ala Ser Glu Arg Ile
          45                  50                  55

 aaa aag gat gat ttg aga gaa tta caa ctc tct gct tct aca cga att     1444
 Lys Lys Asp Asp Leu Arg Glu Leu Gln Leu Ser Ala Ser Thr Arg Ile
      60                  65                  70

 gat gaa ttc aaa acc gaa cag aag gaa gaa aac atg aga ttt ttt gaa     1492
 Asp Glu Phe Lys Thr Glu Gln Lys Glu Glu Asn Met Arg Phe Phe Glu
  75                  80                  85                  90

 aat tct ttt cga aaa cgc cca caa cgt tgc cca cct tca ttt ctt caa     1540
 Asn Ser Phe Arg Lys Arg Pro Gln Arg Cys Pro Pro Ser Phe Leu Gln
                  95                 100                 105

 gaa att gaa tct caa gaa gtt tat gaa ggt gac agt tgt aat ttt gtg     1588
 Glu Ile Glu Ser Gln Glu Val Tyr Glu Gly Asp Ser Cys Asn Phe Val
             110                 115                 120

 tgt cat ttt caa gga tat cct caa cct ata gtg acg tgg tat aac aat     1636
 Cys His Phe Gln Gly Tyr Pro Gln Pro Ile Val Thr Trp Tyr Asn Asn
         125                 130                 135

 gac atg cca atc cca cgt aat caa aac ttt atc att cat tcg ttg gaa     1684
 Asp Met Pro Ile Pro Arg Asn Gln Asn Phe Ile Ile His Ser Leu Glu
     140                 145                 150

 aac tat tca ata tta act ctt tca tct gtt cat cat cag aat gaa ggt     1732
 Asn Tyr Ser Ile Leu Thr Leu Ser Ser Val His His Gln Asn Glu Gly
 155                 160                 165                 170

 tct att act tgt gtg cta ttt aac caa tat gga aca gta aaa aca acc     1780
 Ser Ile Thr Cys Val Leu Phe Asn Gln Tyr Gly Thr Val Lys Thr Thr
                 175                 180                 185

 agt atg ctt aaa gtg aaa gca aaa caa aaa cat gat gtc aaa gca cat     1828
 Ser Met Leu Lys Val Lys Ala Lys Gln Lys His Asp Val Lys Ala His
             190                 195                 200

 aaa gtc cca gtg ttc cat gac tac ttg gat gag gaa gaa gag tta gca     1876
 Lys Val Pro Val Phe His Asp Tyr Leu Asp Glu Glu Glu Glu Leu Ala
         205                 210                 215

 ttg gtg ttt gac caa gca aaa ggc gcc cat cca tct atg agt caa gag     1924
 Leu Val Phe Asp Gln Ala Lys Gly Ala His Pro Ser Met Ser Gln Glu
     220                 225                 230

 ggc caa aca aat ctt cat ttg tta aaa act aac cca cca gtt cct ccc     1972
 Gly Gln Thr Asn Leu His Leu Leu Lys Thr Asn Pro Pro Val Pro Pro
 235                 240                 245                 250

 tct gga gac aca gaa ttg ctt tcc ttt cct gta gaa att cag gta aca     2020
 Ser Gly Asp Thr Glu Leu Leu Ser Phe Pro Val Glu Ile Gln Val Thr
                 255                 260                 265

 gca gct act cct atc cca gaa cag gat aaa gag tct aaa gaa gtg ttt     2068
 Ala Ala Thr Pro Ile Pro Glu Gln Asp Lys Glu Ser Lys Glu Val Phe
             270                 275                 280

 caa act gag gag ctg gaa cct aaa gca atg cct caa gat caa gtt act     2116
 Gln Thr Glu Glu Leu Glu Pro Lys Ala Met Pro Gln Asp Gln Val Thr
         285                 290                 295

 caa tca cca aaa cac aga ttt gta ttt ttg tct gat att act aat gaa     2164
 Gln Ser Pro Lys His Arg Phe Val Phe Leu Ser Asp Ile Thr Asn Glu
     300                 305                 310

 cca cca aaa atg tta caa gaa atg cca aag cat gcc agg tgt aga gaa     2212
 Pro Pro Lys Met Leu Gln Glu Met Pro Lys His Ala Arg Cys Arg Glu
 315                 320                 325                 330

 ggg gat tcc atc att ctt gaa tgt tta ata tct ggt gag ccc cag cca     2260
 Gly Asp Ser Ile Ile Leu Glu Cys Leu Ile Ser Gly Glu Pro Gln Pro
                 335                 340                 345

 gtt gta aca tgg ttt caa aat gga gtc ctt tta aag cag aac cag aag     2308
 Val Val Thr Trp Phe Gln Asn Gly Val Leu Leu Lys Gln Asn Gln Lys
             350                 355                 360

 ttt cag ttt gaa gaa gtt aat tgt agc cac caa tta tat att aag gat     2356
 Phe Gln Phe Glu Glu Val Asn Cys Ser His Gln Leu Tyr Ile Lys Asp
         365                 370                 375

 gtt aat tct caa gat tct gga aaa tat aaa tgt gtt gct gaa aac aat     2404
 Val Asn Ser Gln Asp Ser Gly Lys Tyr Lys Cys Val Ala Glu Asn Asn
     380                 385                 390

 tca ggg gca gtt gaa agt gtt tca gat cta aca gtg gag cct gtc act     2452
 Ser Gly Ala Val Glu Ser Val Ser Asp Leu Thr Val Glu Pro Val Thr
 395                 400                 405                 410

 tat aga gaa aat agt caa ttc gaa aat att ggt gaa att tat gga aaa     2500
 Tyr Arg Glu Asn Ser Gln Phe Glu Asn Ile Gly Glu Ile Tyr Gly Lys
                 415                 420                 425

 tat tcc aga gat cag caa ctg caa gac cag gga gaa tct gta agg gca     2548
 Tyr Ser Arg Asp Gln Gln Leu Gln Asp Gln Gly Glu Ser Val Arg Ala
             430                 435                 440

 cat ttt tat gat tat cca gct ggt ccc ttt act ccc tgg aca aat gta     2596
 His Phe Tyr Asp Tyr Pro Ala Gly Pro Phe Thr Pro Trp Thr Asn Val
         445                 450                 455

 aaa gaa tat tca gta agg gac tat ttt caa agc ctt gag act att gag     2644
 Lys Glu Tyr Ser Val Arg Asp Tyr Phe Gln Ser Leu Glu Thr Ile Glu
     460                 465                 470

 caa ata gac cag aaa gag cag gtg cgt tgc ata cct tct aga gaa aaa     2692
 Gln Ile Asp Gln Lys Glu Gln Val Arg Cys Ile Pro Ser Arg Glu Lys
 475                 480                 485                 490

 att ccc aga ttt gtg cat ggt gct tca aga acc ata aaa atc agc aag     2740
 Ile Pro Arg Phe Val His Gly Ala Ser Arg Thr Ile Lys Ile Ser Lys
                 495                 500                 505

 ccc atc agg gct gaa ttc ata caa tgt cag gct gaa ggg aaa gag aga     2788
 Pro Ile Arg Ala Glu Phe Ile Gln Cys Gln Ala Glu Gly Lys Glu Arg
             510                 515                 520

 cat gta agt gaa aaa tca aag ctg cac caa gca gag ggt act gtt tat     2836
 His Val Ser Glu Lys Ser Lys Leu His Gln Ala Glu Gly Thr Val Tyr
         525                 530                 535

 cca ttt gtt gat gat ttc agt gat gtc act att aag aaa gaa ata aga     2884
 Pro Phe Val Asp Asp Phe Ser Asp Val Thr Ile Lys Lys Glu Ile Arg
     540                 545                 550

 aat aat ttt gga aaa ctt ggt aga tca gaa aag gaa aat gta caa gaa     2932
 Asn Asn Phe Gly Lys Leu Gly Arg Ser Glu Lys Glu Asn Val Gln Glu
 555                 560                 565                 570

 tgt gcc caa agt gac tat tta cca aat att cac tct gag aga att tct     2980
 Cys Ala Gln Ser Asp Tyr Leu Pro Asn Ile His Ser Glu Arg Ile Ser
                 575                 580                 585

 gac agt tac aat aca aaa gat tca tct gcc att gta tat gaa gaa tcc     3028
 Asp Ser Tyr Asn Thr Lys Asp Ser Ser Ala Ile Val Tyr Glu Glu Ser
             590                 595                 600

 ctt ggt gaa gag ata cac tac ccg ggg aaa aag gtg aag cat aga att     3076
 Leu Gly Glu Glu Ile His Tyr Pro Gly Lys Lys Val Lys His Arg Ile
         605                 610                 615

 atc gaa ttt gaa aaa tta cat gta gaa aaa gga gtt cta gaa aaa aga     3124
 Ile Glu Phe Glu Lys Leu His Val Glu Lys Gly Val Leu Glu Lys Arg
     620                 625                 630

 cct acc aga aca tca att gtt aat cct cct caa aag aag att gat gac     3172
 Pro Thr Arg Thr Ser Ile Val Asn Pro Pro Gln Lys Lys Ile Asp Asp
 635                 640                 645                 650

 aaa gcc ttt tca tta aag caa aga gaa tca aga tca agc aat cta aat     3220
 Lys Ala Phe Ser Leu Lys Gln Arg Glu Ser Arg Ser Ser Asn Leu Asn
                 655                 660                 665

 gca aat atg tat cag gca gag aaa atg tct cca aat act gaa tca gat     3268
 Ala Asn Met Tyr Gln Ala Glu Lys Met Ser Pro Asn Thr Glu Ser Asp
             670                 675                 680

 tca tct aac att gca ata aat tta aag ctg ctt tcc tct caa act cat     3316
 Ser Ser Asn Ile Ala Ile Asn Leu Lys Leu Leu Ser Ser Gln Thr His
         685                 690                 695

 aaa gaa ttt gac gca caa gaa agg gaa caa cag gaa aaa ata agt ctt     3364
 Lys Glu Phe Asp Ala Gln Glu Arg Glu Gln Gln Glu Lys Ile Ser Leu
     700                 705                 710

 ata gat aaa cct gca att tct aaa aga gct gaa cat gaa tca cct att     3412
 Ile Asp Lys Pro Ala Ile Ser Lys Arg Ala Glu His Glu Ser Pro Ile
 715                 720                 725                 730

 aca ttt gac tta aag cag ttt cac act caa ata aaa cac aca gat gtg     3460
 Thr Phe Asp Leu Lys Gln Phe His Thr Gln Ile Lys His Thr Asp Val
                 735                 740                 745

 aaa ttc caa gaa tta gat agt ggt caa cca gaa gaa gct tat ttt aaa     3508
 Lys Phe Gln Glu Leu Asp Ser Gly Gln Pro Glu Glu Ala Tyr Phe Lys
             750                 755                 760

 atc caa cat cct gct gac act gag aac att gta ttt gat cta aaa caa     3556
 Ile Gln His Pro Ala Asp Thr Glu Asn Ile Val Phe Asp Leu Lys Gln
         765                 770                 775

 atg tat tct cat ata gga gat cca gct ctg gag ttc caa ggg caa gaa     3604
 Met Tyr Ser His Ile Gly Asp Pro Ala Leu Glu Phe Gln Gly Gln Glu
     780                 785                 790

 act agg gaa cag cag gaa ata cat tat aaa gaa aaa att cct agc cct     3652
 Thr Arg Glu Gln Gln Glu Ile His Tyr Lys Glu Lys Ile Pro Ser Pro
 795                 800                 805                 810

 gaa acg tta caa cct gac aca cac aat atc tct aaa agt gtg caa aat     3700
 Glu Thr Leu Gln Pro Asp Thr His Asn Ile Ser Lys Ser Val Gln Asn
                 815                 820                 825

 aat gta ttt gcc agt caa gaa att tct tcc agt caa gag ctt tca aat     3748
 Asn Val Phe Ala Ser Gln Glu Ile Ser Ser Ser Gln Glu Leu Ser Asn
             830                 835                 840

 aga act atg gtg gag aaa agt agt att gat gaa aat tcc att tct tta     3796
 Arg Thr Met Val Glu Lys Ser Ser Ile Asp Glu Asn Ser Ile Ser Leu
         845                 850                 855

 gaa aaa gaa gtc cga cat gta cag gaa caa aac tta gac att tta aaa     3844
 Glu Lys Glu Val Arg His Val Gln Glu Gln Asn Leu Asp Ile Leu Lys
     860                 865                 870

 act gat ctt tct ctt aaa tcc ttt tct gaa gaa atc tat agt gaa tca     3892
 Thr Asp Leu Ser Leu Lys Ser Phe Ser Glu Glu Ile Tyr Ser Glu Ser
 875                 880                 885                 890

 tgt gcc cta ctt cca acc tca tct gca gat ata gaa gaa act gat ctt     3940
 Cys Ala Leu Leu Pro Thr Ser Ser Ala Asp Ile Glu Glu Thr Asp Leu
                 895                 900                 905

 tct gag aaa agt tgt cct cta gaa aat gga ggc aga agt tcc atc tca     3988
 Ser Glu Lys Ser Cys Pro Leu Glu Asn Gly Gly Arg Ser Ser Ile Ser
             910                 915                 920

 cat ttg aaa aaa gca gca agt gag gaa aag cct tta ggg gtt ggt gaa     4036
 His Leu Lys Lys Ala Ala Ser Glu Glu Lys Pro Leu Gly Val Gly Glu
         925                 930                 935

 atg gaa gaa gaa tgc act cta gaa cca gag ttg gca gca ttt cca aag     4084
 Met Glu Glu Glu Cys Thr Leu Glu Pro Glu Leu Ala Ala Phe Pro Lys
     940                 945                 950

 cag gat ggt ggg aca cag gaa tat aca gat gcc act ttg gaa gac cac     4132
 Gln Asp Gly Gly Thr Gln Glu Tyr Thr Asp Ala Thr Leu Glu Asp His
 955                 960                 965                 970

 aga ggt gat gtt cag gaa gct gac aca ctc cat aga cag ctc tcc ctg     4180
 Arg Gly Asp Val Gln Glu Ala Asp Thr Leu His Arg Gln Leu Ser Leu
                 975                 980                 985

 agt cag tgc ttc cca ctc ttg atg act gaa gaa caa cag aat cca ggt     4228
 Ser Gln Cys Phe Pro Leu Leu Met Thr Glu Glu Gln Gln Asn Pro Gly
             990                 995                1000

 gaa caa ata agt aca aac att cat gcc tct gga gaa gaa aaa tgt tat     4276
 Glu Gln Ile Ser Thr Asn Ile His Ala Ser Gly Glu Glu Lys Cys Tyr
        1005                1010                1015

 gaa gaa gtt caa gtt cag aat gaa gct tct ttc tcc act tta gaa gga     4324
 Glu Glu Val Gln Val Gln Asn Glu Ala Ser Phe Ser Thr Leu Glu Gly
    1020                1025                1030

 gaa atg ata gaa act agt ttt tct caa aat att cct aaa tta gat gag     4372
 Glu Met Ile Glu Thr Ser Phe Ser Gln Asn Ile Pro Lys Leu Asp Glu
1035                1040                1045                1050

 gca cat acc act gag gca gca gaa tct gag acc tcc cta aca caa tat     4420
 Ala His Thr Thr Glu Ala Ala Glu Ser Glu Thr Ser Leu Thr Gln Tyr
                1055                1060                1065

 tta ctt gct gct gga aag cgt gag gtt cct gaa act aaa gac acc aga     4468
 Leu Leu Ala Ala Gly Lys Arg Glu Val Pro Glu Thr Lys Asp Thr Arg
            1070                1075                1080

 gac cag gca aag ctt gtc cag agt gaa tca atc act tca atg gag gtg     4516
 Asp Gln Ala Lys Leu Val Gln Ser Glu Ser Ile Thr Ser Met Glu Val
        1085                1090                1095

 gaa gaa gta act ttc aac act gtg tat gaa tac tac aac cag aaa cag     4564
 Glu Glu Val Thr Phe Asn Thr Val Tyr Glu Tyr Tyr Asn Gln Lys Gln
    1100                1105                1110

 gaa tca cta ggt cgt cca ctt tct cct gag tct gac att tcc att ggt     4612
 Glu Ser Leu Gly Arg Pro Leu Ser Pro Glu Ser Asp Ile Ser Ile Gly
1115                1120                1125                1130

 gtg gga agt aca acc agt gaa gaa ata tct gag tta gat cag ttt tat     4660
 Val Gly Ser Thr Thr Ser Glu Glu Ile Ser Glu Leu Asp Gln Phe Tyr
                1135                1140                1145

 acc cca cca tca tct gtt gaa tat ttt gaa tct cca aag tcc cct gac     4708
 Thr Pro Pro Ser Ser Val Glu Tyr Phe Glu Ser Pro Lys Ser Pro Asp
            1150                1155                1160

 tta tat ttt aat cct tca gat ata act aaa caa tcc tca ata cat tca     4756
 Leu Tyr Phe Asn Pro Ser Asp Ile Thr Lys Gln Ser Ser Ile His Ser
        1165                1170                1175

 gga ggt gag aca gtt gaa aga tat tcc aca cct tta ggg gaa gtt gct     4804
 Gly Gly Glu Thr Val Glu Arg Tyr Ser Thr Pro Leu Gly Glu Val Ala
    1180                1185                1190

 gaa aga tat tca aca cct tcc gaa ggt gag gta gga gaa aga tac tcc     4852
 Glu Arg Tyr Ser Thr Pro Ser Glu Gly Glu Val Gly Glu Arg Tyr Ser
1195                1200                1205                1210

 aca ccc cca ggg gag aca cta gag aga tac tcc aca cct cca gga gag     4900
 Thr Pro Pro Gly Glu Thr Leu Glu Arg Tyr Ser Thr Pro Pro Gly Glu
                1215                1220                1225

 act cta gag aga tac tcc aca ccc cca gga gag act cta gag aga tat     4948
 Thr Leu Glu Arg Tyr Ser Thr Pro Pro Gly Glu Thr Leu Glu Arg Tyr
            1230                1235                1240

 tcc aca ccc cca gga gag act ctg gag aga tac tcc aca ccc cca gga     4996
 Ser Thr Pro Pro Gly Glu Thr Leu Glu Arg Tyr Ser Thr Pro Pro Gly
        1245                1250                1255

 gag act cta gag cga tat tcc aca ccc cca ggg gag gca cta gag aga     5044
 Glu Thr Leu Glu Arg Tyr Ser Thr Pro Pro Gly Glu Ala Leu Glu Arg
    1260                1265                1270

 tat tct att cct act gga gga cca aac ccc act ggt act ttt aaa aca     5092
 Tyr Ser Ile Pro Thr Gly Gly Pro Asn Pro Thr Gly Thr Phe Lys Thr
1275                1280                1285                1290

 tat cca tca aaa ata gaa agg gaa gac ggt aca cca aat gag cat ttc     5140
 Tyr Pro Ser Lys Ile Glu Arg Glu Asp Gly Thr Pro Asn Glu His Phe
                1295                1300                1305

 tac aca cct aca gaa gag agg ggt tca gct tat gaa ata tgg cgt tcc     5188
 Tyr Thr Pro Thr Glu Glu Arg Gly Ser Ala Tyr Glu Ile Trp Arg Ser
            1310                1315                1320

 gat tca ttt ggt aca ccc aat gaa gcc att gag cca aaa gac aat gaa     5236
 Asp Ser Phe Gly Thr Pro Asn Glu Ala Ile Glu Pro Lys Asp Asn Glu
        1325                1330                1335

 atg cct cca tct ttt att gaa cct ctg acc aaa agg aag gta tat gaa     5284
 Met Pro Pro Ser Phe Ile Glu Pro Leu Thr Lys Arg Lys Val Tyr Glu
    1340                1345                1350

 aac aca aca cta ggc ttc att gtt gaa gtt gaa ggt ctt cca gtt cct     5332
 Asn Thr Thr Leu Gly Phe Ile Val Glu Val Glu Gly Leu Pro Val Pro
1355                1360                1365                1370

 ggt gtg aaa tgg tat cga aat aaa tct tta cta gag cca gat gaa aga     5380
 Gly Val Lys Trp Tyr Arg Asn Lys Ser Leu Leu Glu Pro Asp Glu Arg
                1375                1380                1385

 atc aaa atg gaa aga gtg ggt aat gtg tgt tca ctg gaa att tct aac     5428
 Ile Lys Met Glu Arg Val Gly Asn Val Cys Ser Leu Glu Ile Ser Asn
            1390                1395                1400

 att caa aaa gga gaa ggg gga gag tac atg tgt cat gct gta aac atc     5476
 Ile Gln Lys Gly Glu Gly Gly Glu Tyr Met Cys His Ala Val Asn Ile
        1405                1410                1415

 ata ggg gaa gca aag agc ttt gca aat gta gac ata atg ccc cag gaa     5524
 Ile Gly Glu Ala Lys Ser Phe Ala Asn Val Asp Ile Met Pro Gln Glu
    1420                1425                1430

 gaa aga gtg gtg gca cta cca cct cca gta aca cat cag cat gtc atg     5572
 Glu Arg Val Val Ala Leu Pro Pro Pro Val Thr His Gln His Val Met
1435                1440                1445                1450

 gag ttt gat ttg gaa cac acc aca tca tca aga aca cct tct cct caa     5620
 Glu Phe Asp Leu Glu His Thr Thr Ser Ser Arg Thr Pro Ser Pro Gln
                1455                1460                1465

 gaa att gtc ctg gaa gtt gaa tta agt gaa aaa gac gtt aaa gaa ttt     5668
 Glu Ile Val Leu Glu Val Glu Leu Ser Glu Lys Asp Val Lys Glu Phe
            1470                1475                1480

 gag aag cag gtg aaa ata gtg aca gtt ccc gaa ttt act cct gac cat     5716
 Glu Lys Gln Val Lys Ile Val Thr Val Pro Glu Phe Thr Pro Asp His
        1485                1490                1495

 aaa agt atg att gtg agt cta gat gtt ctt cca ttt aat ttt gta gat     5764
 Lys Ser Met Ile Val Ser Leu Asp Val Leu Pro Phe Asn Phe Val Asp
    1500                1505                1510

 cca aat atg gat tca agg gag gga gaa gac aaa gaa cta aaa att gat     5812
 Pro Asn Met Asp Ser Arg Glu Gly Glu Asp Lys Glu Leu Lys Ile Asp
1515                1520                1525                1530

 tta gaa gta ttt gaa atg cct cct cgc ttt ata atg cct att tgt gat     5860
 Leu Glu Val Phe Glu Met Pro Pro Arg Phe Ile Met Pro Ile Cys Asp
                1535                1540                1545

 ttt aaa att cca gaa aat tca gat gct gta ttc aaa tgt tca gtc ata     5908
 Phe Lys Ile Pro Glu Asn Ser Asp Ala Val Phe Lys Cys Ser Val Ile
            1550                1555                1560

 ggg atc ccg act ccc gaa gtt aag tgg tat aaa gaa tat atg tgt att     5956
 Gly Ile Pro Thr Pro Glu Val Lys Trp Tyr Lys Glu Tyr Met Cys Ile
        1565                1570                1575

 gag cca gat aat att aaa tac gtg att agc gag gag aag gga agt cac     6004
 Glu Pro Asp Asn Ile Lys Tyr Val Ile Ser Glu Glu Lys Gly Ser His
    1580                1585                1590

 act ctt aaa att cga aat gtc tgt ctt tct gat agt gca aca tac agg     6052
 Thr Leu Lys Ile Arg Asn Val Cys Leu Ser Asp Ser Ala Thr Tyr Arg
1595                1600                1605                1610

 tgc aga gct gtg aat tgt gta gga gag gct atc tgt cgg gga ttc ctc     6100
 Cys Arg Ala Val Asn Cys Val Gly Glu Ala Ile Cys Arg Gly Phe Leu
                1615                1620                1625

 acc atg gga gat tct gaa ata ttt gct gtg ata gca aag aaa agc aaa     6148
 Thr Met Gly Asp Ser Glu Ile Phe Ala Val Ile Ala Lys Lys Ser Lys
            1630                1635                1640

 gtg act tta agc agt tta atg gaa gaa ttg gtc tta aag agc aac tac     6196
 Val Thr Leu Ser Ser Leu Met Glu Glu Leu Val Leu Lys Ser Asn Tyr
        1645                1650                1655

 aca gac agt ttt ttt gaa ttt cag gtg gtg gaa ggg cct ccc agg ttt     6244
 Thr Asp Ser Phe Phe Glu Phe Gln Val Val Glu Gly Pro Pro Arg Phe
    1660                1665                1670

 atc aaa ggt att tct gac tgt tat gca cca ata ggt aca gca gca tat     6292
 Ile Lys Gly Ile Ser Asp Cys Tyr Ala Pro Ile Gly Thr Ala Ala Tyr
1675                1680                1685                1690

 ttt cag tgc tag tcg tggctctcca agaaccacgg tttactggta caacagatgg     6347
 Phe Gln Cys 


 gcaaattggt ccaggagaaa ggtcaccggt gcaggcaagc gggccaggtc cccaaccggt   6407

 taacagcgtc gaacaaggta caggacaact ggggtgtccc acaacaccga ggcgtgaggt   6467

 ggccccacca aacgtcgggg cccaaacaag agggcataac tgggataaac agccgtaagc   6527

 caaccacaca ttcatgggtg atacgagaga aggaacactg gggg                    6571




      <210> 102
      <211> 2480
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (77)..(2254)

      <400> 102
 ccgggtcgag ccacgcgtcc ggctggaggc agttgcttcc ctgtagaggg tccggctgcg     60

 gccagtattt tgtgtc    atg act tct caa gag aag aca gaa gag tat cct     109
                      Met Thr Ser Gln Glu Lys Thr Glu Glu Tyr Pro
                        1               5                  10

 ttt gca gat ata ttt gat gaa gat gaa act gaa agg aat ttt ttg ttg      157
 Phe Ala Asp Ile Phe Asp Glu Asp Glu Thr Glu Arg Asn Phe Leu Leu
              15                  20                  25

 tcc aaa cct gtt tgc ttt gtt gta ttt ggg aaa cca ggt gtt ggg aaa      205
 Ser Lys Pro Val Cys Phe Val Val Phe Gly Lys Pro Gly Val Gly Lys
          30                  35                  40

 aca aca tta gcc cgt tac ata aca cag gca tgg aaa tgt att cgt gtt      253
 Thr Thr Leu Ala Arg Tyr Ile Thr Gln Ala Trp Lys Cys Ile Arg Val
      45                  50                  55

 gaa gct ttg cca att tta gaa gaa cag att gct gct gaa acc gaa tca      301
 Glu Ala Leu Pro Ile Leu Glu Glu Gln Ile Ala Ala Glu Thr Glu Ser
  60                  65                  70                  75

 gga gtt atg ttg caa tca atg ttg atc agc ggt caa agc att cca gat      349
 Gly Val Met Leu Gln Ser Met Leu Ile Ser Gly Gln Ser Ile Pro Asp
                  80                  85                  90

 gaa ctt gtc ata aag cta atg ttg gag aag ctc aac tcc cca gaa gtc      397
 Glu Leu Val Ile Lys Leu Met Leu Glu Lys Leu Asn Ser Pro Glu Val
              95                 100                 105

 tgt cac ttt ggt tat att atc act gaa ata cca tca ctt tca cag gat      445
 Cys His Phe Gly Tyr Ile Ile Thr Glu Ile Pro Ser Leu Ser Gln Asp
         110                 115                 120

 gcc atg act acc tta cag caa ata gaa tta att aaa aac tta aac ctg      493
 Ala Met Thr Thr Leu Gln Gln Ile Glu Leu Ile Lys Asn Leu Asn Leu
     125                 130                 135

 aaa cct gat gtt ata atc aat ata aag tgt cct gac tat gat ttg tgc      541
 Lys Pro Asp Val Ile Ile Asn Ile Lys Cys Pro Asp Tyr Asp Leu Cys
 140                 145                 150                 155

 cag aga att tct ggg caa aga cag cac aat aat acg gga tac ata tac      589
 Gln Arg Ile Ser Gly Gln Arg Gln His Asn Asn Thr Gly Tyr Ile Tyr
                 160                 165                 170

 agt aga gac cag tgg gat cct gaa gtc att gag aat cat agg aaa aag      637
 Ser Arg Asp Gln Trp Asp Pro Glu Val Ile Glu Asn His Arg Lys Lys
             175                 180                 185

 aag aaa gaa gcc caa aag gac gga aaa gga gaa gag gaa gaa gag gaa      685
 Lys Lys Glu Ala Gln Lys Asp Gly Lys Gly Glu Glu Glu Glu Glu Glu
         190                 195                 200

 gaa gag caa gaa gaa gaa gag gca ttt att gcc gaa atg cag atg gtg      733
 Glu Glu Gln Glu Glu Glu Glu Ala Phe Ile Ala Glu Met Gln Met Val
     205                 210                 215

 gct gaa att ctt cat cat cta gtt cag agg cct gaa gat tat ttg gaa      781
 Ala Glu Ile Leu His His Leu Val Gln Arg Pro Glu Asp Tyr Leu Glu
 220                 225                 230                 235

 aat gtt gaa aac att gtt aag ctt tat aag gaa aca att ctc caa act      829
 Asn Val Glu Asn Ile Val Lys Leu Tyr Lys Glu Thr Ile Leu Gln Thr
                 240                 245                 250

 tta gaa gaa gta atg gct gaa cac aat ccc cag tat ctc att ggg cta      877
 Leu Glu Glu Val Met Ala Glu His Asn Pro Gln Tyr Leu Ile Gly Leu
             255                 260                 265

 aat gga aat aaa cca gca gag gag ctc ttt atg att gtt atg gat cga      925
 Asn Gly Asn Lys Pro Ala Glu Glu Leu Phe Met Ile Val Met Asp Arg
         270                 275                 280

 ctt aaa tat ctg aac cta aaa aga gca gct att cta acc aaa ctt cag      973
 Leu Lys Tyr Leu Asn Leu Lys Arg Ala Ala Ile Leu Thr Lys Leu Gln
     285                 290                 295

 ggt gca gag gaa gaa att aat gac aca atg gaa aat gat gag cta ttt     1021
 Gly Ala Glu Glu Glu Ile Asn Asp Thr Met Glu Asn Asp Glu Leu Phe
 300                 305                 310                 315

 cgt act ctt gca tct tat aaa ctt att gca cca aga tac aga tgg caa     1069
 Arg Thr Leu Ala Ser Tyr Lys Leu Ile Ala Pro Arg Tyr Arg Trp Gln
                 320                 325                 330

 aga agt aaa tgg gga cgt aca tgt cct gtg aat tta aaa gat ggt aac     1117
 Arg Ser Lys Trp Gly Arg Thr Cys Pro Val Asn Leu Lys Asp Gly Asn
             335                 340                 345

 att tat tca gga tta cca gat tat tct gtg agt ttt cta ggt aaa atc     1165
 Ile Tyr Ser Gly Leu Pro Asp Tyr Ser Val Ser Phe Leu Gly Lys Ile
         350                 355                 360

 tac tgt ctt tca tca gaa gaa gca tta aaa cca ttt ttg ttg aac cca     1213
 Tyr Cys Leu Ser Ser Glu Glu Ala Leu Lys Pro Phe Leu Leu Asn Pro
     365                 370                 375

 cgt ccc tat ctg ctt cca cct atg cca gga cca cca tgt aaa gta ttc     1261
 Arg Pro Tyr Leu Leu Pro Pro Met Pro Gly Pro Pro Cys Lys Val Phe
 380                 385                 390                 395

 ata ctt gga cct caa tat tca ggg aaa aca aca ctt tgc aat atg ctt     1309
 Ile Leu Gly Pro Gln Tyr Ser Gly Lys Thr Thr Leu Cys Asn Met Leu
                 400                 405                 410

 gca gaa aat tac aaa gga aag gta gtc gac tat gcc caa ctt gtt cag     1357
 Ala Glu Asn Tyr Lys Gly Lys Val Val Asp Tyr Ala Gln Leu Val Gln
             415                 420                 425

 cca cgt ttt gat aaa gcc cgt gaa aca tta gta gaa aat acc ata gct     1405
 Pro Arg Phe Asp Lys Ala Arg Glu Thr Leu Val Glu Asn Thr Ile Ala
         430                 435                 440

 gag gcc act gca gca gca att aaa gtt gtg aaa gaa aag ctt ctc agg     1453
 Glu Ala Thr Ala Ala Ala Ile Lys Val Val Lys Glu Lys Leu Leu Arg
     445                 450                 455

 gaa ctg caa gct aga aaa caa gct gaa aca gct tta aga gaa ttt caa     1501
 Glu Leu Gln Ala Arg Lys Gln Ala Glu Thr Ala Leu Arg Glu Phe Gln
 460                 465                 470                 475

 agg caa tat gaa aaa atg gag ttt gga gta ttc cca atg gag gca aca     1549
 Arg Gln Tyr Glu Lys Met Glu Phe Gly Val Phe Pro Met Glu Ala Thr
                 480                 485                 490

 cac tca tca att gat gaa gaa ggg tac att caa ggc tcc caa agg gac     1597
 His Ser Ser Ile Asp Glu Glu Gly Tyr Ile Gln Gly Ser Gln Arg Asp
             495                 500                 505

 aga ggc agc tct tta gtg gac acc gaa gaa gcc aaa aca aag tca gaa     1645
 Arg Gly Ser Ser Leu Val Asp Thr Glu Glu Ala Lys Thr Lys Ser Glu
         510                 515                 520

 aat gtc ctc cat gat caa gct gct aaa gtt gat aaa gat gat gga aaa     1693
 Asn Val Leu His Asp Gln Ala Ala Lys Val Asp Lys Asp Asp Gly Lys
     525                 530                 535

 gaa act ggt gaa aca ttc aca ttt aaa agg cat tct caa gat gct agt     1741
 Glu Thr Gly Glu Thr Phe Thr Phe Lys Arg His Ser Gln Asp Ala Ser
 540                 545                 550                 555

 caa gat gta aag ttg tat tca gat aca gcc cca aca gaa gac ttg ata     1789
 Gln Asp Val Lys Leu Tyr Ser Asp Thr Ala Pro Thr Glu Asp Leu Ile
                 560                 565                 570

 gaa gag gta act gca gat cat cca gag gtt gtg acc atg att gaa gag     1837
 Glu Glu Val Thr Ala Asp His Pro Glu Val Val Thr Met Ile Glu Glu
             575                 580                 585

 act ata aaa atg tca cag gat ata aac ttt gaa cag cca tat gaa aaa     1885
 Thr Ile Lys Met Ser Gln Asp Ile Asn Phe Glu Gln Pro Tyr Glu Lys
         590                 595                 600

 cat gct gaa atc tta cag gaa gtc ctt gga gag gta atg gaa gaa aac     1933
 His Ala Glu Ile Leu Gln Glu Val Leu Gly Glu Val Met Glu Glu Asn
     605                 610                 615

 aag gat agg ttt cct ggt gcc cca aaa tat gga ggc tgg att gtg gac     1981
 Lys Asp Arg Phe Pro Gly Ala Pro Lys Tyr Gly Gly Trp Ile Val Asp
 620                 625                 630                 635

 aac tgc cct att gta aaa gaa ttg tgg atg gcc tta atc aag aaa gga     2029
 Asn Cys Pro Ile Val Lys Glu Leu Trp Met Ala Leu Ile Lys Lys Gly
                 640                 645                 650

 att ata cct gat ttg gtc atc tat tta tca gat aca gaa aac aat gga     2077
 Ile Ile Pro Asp Leu Val Ile Tyr Leu Ser Asp Thr Glu Asn Asn Gly
             655                 660                 665

 aaa tgt tta ttt aat aga ata tat tta cag aag aaa tct gaa att gac     2125
 Lys Cys Leu Phe Asn Arg Ile Tyr Leu Gln Lys Lys Ser Glu Ile Asp
         670                 675                 680

 tct aag att tta gaa aga tta tta gaa gaa cta caa aag aaa aaa aaa     2173
 Ser Lys Ile Leu Glu Arg Leu Leu Glu Glu Leu Gln Lys Lys Lys Lys
     685                 690                 695

 aga aga aga aga agc aag aaa agc cac aga aga gga att gag act cga     2221
 Arg Arg Arg Arg Ser Lys Lys Ser His Arg Arg Gly Ile Glu Thr Arg
 700                 705                 710                 715

 aga aga aaa tcg aag gct acc tgg aac tta tga aagtgaag gcaaaaggca     2272
 Arg Arg Lys Ser Lys Ala Thr Trp Asn Leu 
                 720                 725

 agcacagatt gctatgactg atgatgtgtc atggtattgt tactgcaagc aattgcagta   2332

 tttcaagtga attatagact gggtgatcac atttcccaat ttgtccatga gagcccaggt   2392

 ttatgcctat attcttgaag tctttatagt accttttatt cttaaagtgt tccagtttgt   2452

 atactaaata atattgttac tgaagtaa                                      2480




      <210> 103
      <211> 381
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(253)

      <400> 103
 ttttttataa tgccaacttt gtacaaaaaa gcaggcttta attaaggagg ttaacacc       58                                                                 
 atg gaa aga tgc aat tct agt act ttg tta gga aac tgc att aaa gca      106
 Met Glu Arg Cys Asn Ser Ser Thr Leu Leu Gly Asn Cys Ile Lys Ala
   1               5                  10                  15

 gtt ctg cct tgt ata atc tgt aag tac cta tta aga caa aat act tct      154
 Val Leu Pro Cys Ile Ile Cys Lys Tyr Leu Leu Arg Gln Asn Thr Ser
              20                  25                  30

 aaa gat act tat gaa atg tat aca tat ttt ttc ttg cac gtt aca aag      202
 Lys Asp Thr Tyr Glu Met Tyr Thr Tyr Phe Phe Leu His Val Thr Lys
          35                  40                  45

 aaa ata ctc aat tgc ata aca cgg atg ttt gac aaa ctt ttt ttt ttt      250
 Lys Ile Leu Asn Cys Ile Thr Arg Met Phe Asp Lys Leu Phe Phe Phe
      50                  55                  60

 taa tgca tttctttctt tcatgagaca ttgaaaccac tgatagctca tttcacccta      307
 


 tcttaaaccc ttcaccgagg tacctgctag ctatcttacc cagctttctt gtacaaagtt    367

 ggcattataa aaaa                                                      381




      <210> 104
      <211> 1821
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (139)..(1197)

      <400> 104
 tctctccccg tagtgagaaa gccacgtgct tccagctgtg tgggacaggt cagcacttat     60

 caccccgcac ctgtctctcc aggacattcc acagccgtgg tcagtctgcc cggctcccag    120

 caacacctct cagcgaac  atg ttt gta gcc ctg cac tcc tac tca gcc cat     171
                      Met Phe Val Ala Leu His Ser Tyr Ser Ala His
                        1               5                  10

 gga ccc gat gag ctg gac ctg caa aag gga gaa ggc gtc agg gtc ctg      219
 Gly Pro Asp Glu Leu Asp Leu Gln Lys Gly Glu Gly Val Arg Val Leu
              15                  20                  25

 ggg aag tgc cag gac ggc tgg ctc agg ggc gtc tcc ttg gtc acc ggg      267
 Gly Lys Cys Gln Asp Gly Trp Leu Arg Gly Val Ser Leu Val Thr Gly
          30                  35                  40

 cga gtc ggc atc ttc cca aac aat tac gtc atc ccc att ttc aga aag      315
 Arg Val Gly Ile Phe Pro Asn Asn Tyr Val Ile Pro Ile Phe Arg Lys
      45                  50                  55

 acc tct agt ttt cca gac tcc cgg agc cct ggt ctc tac acc aca tgg      363
 Thr Ser Ser Phe Pro Asp Ser Arg Ser Pro Gly Leu Tyr Thr Thr Trp
  60                  65                  70                  75

 acg tta tcc acc tcc tct gtg tcc tcc caa ggc agc att tca gaa ggt      411
 Thr Leu Ser Thr Ser Ser Val Ser Ser Gln Gly Ser Ile Ser Glu Gly
                  80                  85                  90

 gat cca cgg caa agc cgt ccc ttc aaa tcc gtc ttt gtg ccc act gcc      459
 Asp Pro Arg Gln Ser Arg Pro Phe Lys Ser Val Phe Val Pro Thr Ala
              95                 100                 105

 ata gtc aac ccc gtg aga agc aca gcc ggc cct ggg act tta gga caa      507
 Ile Val Asn Pro Val Arg Ser Thr Ala Gly Pro Gly Thr Leu Gly Gln
         110                 115                 120

 ggg tct ctt cgg aaa ggg cgg agc agc atg aga aag agt aag tgg tgg      555
 Gly Ser Leu Arg Lys Gly Arg Ser Ser Met Arg Lys Ser Lys Trp Trp
     125                 130                 135

 cag aga gat gga tcc ctg cag aga ccc ctc cag tcc ggg atc ccc act      603
 Gln Arg Asp Gly Ser Leu Gln Arg Pro Leu Gln Ser Gly Ile Pro Thr
 140                 145                 150                 155

 ctc gtg gta ggc tcc ctc aga cgc agc ccc acc atg gtc ctt cgg cct      651
 Leu Val Val Gly Ser Leu Arg Arg Ser Pro Thr Met Val Leu Arg Pro
                 160                 165                 170

 cag cag ttc caa ttc tac cag cca cag ggg atc ccc tcc tcc ccc tca      699
 Gln Gln Phe Gln Phe Tyr Gln Pro Gln Gly Ile Pro Ser Ser Pro Ser
             175                 180                 185

 gcc gtg gtg gtg gag atg ggg tcc aag cct gcc ctc acg ggg gag ccc      747
 Ala Val Val Val Glu Met Gly Ser Lys Pro Ala Leu Thr Gly Glu Pro
         190                 195                 200

 gcc ctc acg tgc atc agc agg ggc agt gag gcc cgg atc cac tcc gcg      795
 Ala Leu Thr Cys Ile Ser Arg Gly Ser Glu Ala Arg Ile His Ser Ala
     205                 210                 215

 gcc agc tcc ctc att atg gaa gac aaa gaa atc ccc atc aag agt gag      843
 Ala Ser Ser Leu Ile Met Glu Asp Lys Glu Ile Pro Ile Lys Ser Glu
 220                 225                 230                 235

 cct ctg cca aaa ccg ccc gca tct gcc cca cca tcc atc ctg gtg aaa      891
 Pro Leu Pro Lys Pro Pro Ala Ser Ala Pro Pro Ser Ile Leu Val Lys
                 240                 245                 250

 cca gaa aac tca aga aat ggc atc gaa aag caa gtc aaa acc gtg aga      939
 Pro Glu Asn Ser Arg Asn Gly Ile Glu Lys Gln Val Lys Thr Val Arg
             255                 260                 265

 ttt cag aat tac agc cct cct ccc acc aaa cat tac acc tcc cat ccc      987
 Phe Gln Asn Tyr Ser Pro Pro Pro Thr Lys His Tyr Thr Ser His Pro
         270                 275                 280

 acc tcc gga aag cct gaa cag cca gcc acc ctc aag gcg tcc cag cct     1035
 Thr Ser Gly Lys Pro Glu Gln Pro Ala Thr Leu Lys Ala Ser Gln Pro
     285                 290                 295

 gaa gca gcg tcc ttg ggc cca gag atg acc gtc cta ttt gcc cac cga     1083
 Glu Ala Ala Ser Leu Gly Pro Glu Met Thr Val Leu Phe Ala His Arg
 300                 305                 310                 315

 agt ggc tgc cac tcc gga cag cag aca gac ctc cgg aga aag tca gct     1131
 Ser Gly Cys His Ser Gly Gln Gln Thr Asp Leu Arg Arg Lys Ser Ala
                 320                 325                 330

 ctt gcc aag gcc aca acc ctg gtg tcc act gcc tca ggc acg cag acc     1179
 Leu Ala Lys Ala Thr Thr Leu Val Ser Thr Ala Ser Gly Thr Gln Thr
             335                 340                 345

 gtg ttt ccc agc aaa tga acctac gggtggcttt tcctagaccc caaagaggtg     1233
 Val Phe Pro Ser Lys 
         350

 aattgcattt aaatacagtc tgcctccact gagggcatcc tgccattctt tggggacttg   1293

 agcatgggtc cttgttcttc ctatttcacc tccaggaaag caaaagtggg agcagaaatt   1353

 cctgccctgg gtgggaggat agatggcgtg gccttccaaa catacaaaca taatgatttg   1413

 atgccacaaa gctcgcttac tcagaccaag gagtgaaaaa ttgtcgtgcc cactttatgc   1473

 cccagcatgg agtatgtggc ctcttgtcat ccccgtgtta ctgtgtagaa tttctatggt   1533

 gtcctaaagg gggctgcagc aggggtgtga caacggtggg attgttggcg ttgcttcttt   1593

 gaccttacaa tatcctcaac aagcattaga acaacttctg ccatcttctg gggcctgtac   1653

 actggccact agtagctgcc atatcttttt ccctctgtaa agtcataatc ctggctgcaa   1713

 agggaggatt tctgcgcggg gtgtgaggtg gatactttga acattctgag aacccaataa   1773

 aactagaagg agcaatcagt ccaacttaaa caaagatcat taattaac                1821




      <210> 105
      <211> 1902
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (214)..(1491)

      <400> 105
 aggcatcttc cctatcttgt tgtagagcca aacctcaccg caagacacct tttagagaag     60

 aacaaaggtc gccagtcatc ctgcacaaaa aacctgtccc tggtgtcctc gtcctccaga    120

 ggcaacacgt ctaccctccg taggggccca gggtccagga ggaaggtgcc tgggcagttt    180

 tccatcacaa cagccttgaa cactctcaac cgg atg gtc cat tct cct tca ggg     234
                                      Met Val His Ser Pro Ser Gly
                                        1               5

 cgc cat atg gta gag atc agc acc cca gtg ctc atc agc tcc agc aac      282
 Arg His Met Val Glu Ile Ser Thr Pro Val Leu Ile Ser Ser Ser Asn
          10                  15                  20

 ccc tct gtg atc acc cag ccc atg gag aaa gca gac gtt cct tcc agc      330
 Pro Ser Val Ile Thr Gln Pro Met Glu Lys Ala Asp Val Pro Ser Ser
      25                  30                  35

 tgt gtg gga cag gtc agc act tat cac ccc gca cct gtc tct cca gga      378
 Cys Val Gly Gln Val Ser Thr Tyr His Pro Ala Pro Val Ser Pro Gly
  40                  45                  50                  55

 cat tcc aca gcc gtg gtc agt ctg cct ggc tcc cag caa cac ctc tca      426
 His Ser Thr Ala Val Val Ser Leu Pro Gly Ser Gln Gln His Leu Ser
                  60                  65                  70

 gcg aac atg ttt gta gcc ctg cac tcc tac tca gcc cat gga ccc gat      474
 Ala Asn Met Phe Val Ala Leu His Ser Tyr Ser Ala His Gly Pro Asp
              75                  80                  85

 gag ctg gac ctg caa aag gga gaa ggc gtc agg gtc ctg ggg aag tgc      522
 Glu Leu Asp Leu Gln Lys Gly Glu Gly Val Arg Val Leu Gly Lys Cys
          90                  95                 100

 cag gac ggc tgg ctc agg ggc gtc tcc ttg gtc acc ggg cga gtc ggc      570
 Gln Asp Gly Trp Leu Arg Gly Val Ser Leu Val Thr Gly Arg Val Gly
     105                 110                 115

 atc ttc cca aac aat tac gtc atc ccc att ttc aga aag acc tct agt      618
 Ile Phe Pro Asn Asn Tyr Val Ile Pro Ile Phe Arg Lys Thr Ser Ser
 120                 125                 130                 135

 ttt cca gac tcc cgg agc cct ggt ctc tac acc aca tgg acg tta tcc      666
 Phe Pro Asp Ser Arg Ser Pro Gly Leu Tyr Thr Thr Trp Thr Leu Ser
                 140                 145                 150

 acc tcc tct gtg tcc tcc caa ggc agc att tca gaa ggt gat cca cgg      714
 Thr Ser Ser Val Ser Ser Gln Gly Ser Ile Ser Glu Gly Asp Pro Arg
             155                 160                 165

 caa agc cgt ccc ttc aaa tcc gtc ttt gtg ccc act gcc ata gtc aac      762
 Gln Ser Arg Pro Phe Lys Ser Val Phe Val Pro Thr Ala Ile Val Asn
         170                 175                 180

 ccc gtg aga agc aca gcc ggc cct ggg act tta gga caa ggg tct ctt      810
 Pro Val Arg Ser Thr Ala Gly Pro Gly Thr Leu Gly Gln Gly Ser Leu
     185                 190                 195

 cgg aaa ggg cgg agc agc atg aga aag agt aag tgg tgg cag aga gat      858
 Arg Lys Gly Arg Ser Ser Met Arg Lys Ser Lys Trp Trp Gln Arg Asp
 200                 205                 210                 215

 gga tcc ctg cag aga ccc ctc cag tcc ggg atc ccc act ctc gtg gta      906
 Gly Ser Leu Gln Arg Pro Leu Gln Ser Gly Ile Pro Thr Leu Val Val
                 220                 225                 230

 ggc tcc ctc aga cgc agc ccc acc atg gtc ctt cgg cct cag cag ttc      954
 Gly Ser Leu Arg Arg Ser Pro Thr Met Val Leu Arg Pro Gln Gln Phe
             235                 240                 245

 caa ttc tac cag cca cag ggg atc ccc tcc tcc ccc tca gcc gtg gtg     1002
 Gln Phe Tyr Gln Pro Gln Gly Ile Pro Ser Ser Pro Ser Ala Val Val
         250                 255                 260

 gtg gag atg ggg tcc aag cct gcc ctc acg ggg gag ccc gcc ctc acg     1050
 Val Glu Met Gly Ser Lys Pro Ala Leu Thr Gly Glu Pro Ala Leu Thr
     265                 270                 275

 tgc atc agc agg ggc agt gag gcc cgg atc cac tcc gcg gcc agc tcc     1098
 Cys Ile Ser Arg Gly Ser Glu Ala Arg Ile His Ser Ala Ala Ser Ser
 280                 285                 290                 295

 ctc att atg gaa gac aaa gaa atc ccc atc aag agt gag cct ctg cca     1146
 Leu Ile Met Glu Asp Lys Glu Ile Pro Ile Lys Ser Glu Pro Leu Pro
                 300                 305                 310

 aaa ccg ccc gca tct gcc cca cca tcc atc ctg gtg aaa cca gaa aac     1194
 Lys Pro Pro Ala Ser Ala Pro Pro Ser Ile Leu Val Lys Pro Glu Asn
             315                 320                 325

 tca aga aat ggc atc gaa aag caa gtc aaa acc gtg aga ttt cag aat     1242
 Ser Arg Asn Gly Ile Glu Lys Gln Val Lys Thr Val Arg Phe Gln Asn
         330                 335                 340

 tac agc cct cct ccc acc aaa cat tac acc tcc cat ccc acc tcc gga     1290
 Tyr Ser Pro Pro Pro Thr Lys His Tyr Thr Ser His Pro Thr Ser Gly
     345                 350                 355

 aag cct gaa cag cca gcc acc ctc aag gcg tcc cag cct gaa gca gcg     1338
 Lys Pro Glu Gln Pro Ala Thr Leu Lys Ala Ser Gln Pro Glu Ala Ala
 360                 365                 370                 375

 tcc ttg ggc cca gag atg acc gtc cta ttt gcc cac cga agt ggc tgc     1386
 Ser Leu Gly Pro Glu Met Thr Val Leu Phe Ala His Arg Ser Gly Cys
                 380                 385                 390

 cac tcc gga cag cag aca gac ctc cgg aga aag tca gct ctt gcc aag     1434
 His Ser Gly Gln Gln Thr Asp Leu Arg Arg Lys Ser Ala Leu Ala Lys
             395                 400                 405

 gcc aca acc ctg gtg tcc act gcc tca ggc acg cag acc gtg ttt ccc     1482
 Ala Thr Thr Leu Val Ser Thr Ala Ser Gly Thr Gln Thr Val Phe Pro
         410                 415                 420

 agc aaa tga acctacg ggtggctttt cctagacccc aaagaggtga attgcattta     1538
 Ser Lys 
     425

 aatacagtct gcctccactg agggcatcct gccattcttt ggggacttga gcatgggtcc   1598

 ttgttcttcc tatttcacct ccaggaaagc aaaagtggga gcagaaattc ctgccctggg   1658

 tgggaggata gatggcgtgg ccttccaaac atacaaacat aatgatttga tgccacaaag   1718

 ctcgcttact cagaccaagg agtgaaaaat tgtcgtgccc actttatgcc ccagcatgga   1778

 gtatgtggcc tcttgtcatc cccgtgttac tgtgtagaat ttctatggtg tcctaaaggg   1838

 ggctgcagca ggggtgtgac aacggtggga ttgttggcgt tgcttctttg accttacaat   1898

 atcc                                                                1902




      <210> 106
      <211> 872
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (174)..(545)

      <400> 106
 ccgtgtgtcg tgagtgcata gcattgtccc agtggaaaca ggcatggggg taccaccgcc     60

 gtgctgtacc ttacgctgtc tacccaaggc tccctgcctg catgcatggt tcttgagctt    120

 ggagcgggcc gatagcgtcc aaaccatgcg cagtgtcggc tcccgaggag aag   atg     176
                                                              Met
                                                                1

 tca cgt atg ctg ctg ctc ctg cgg cca tca gcc cac gac atg gcc ggc      224
 Ser Arg Met Leu Leu Leu Leu Arg Pro Ser Ala His Asp Met Ala Gly
               5                  10                  15

 gat ttc gtc cca ccc cac cca cag acg gcc ttc tgc aat tcc gac ctc      272
 Asp Phe Val Pro Pro His Pro Gln Thr Ala Phe Cys Asn Ser Asp Leu
          20                  25                  30

 gtc atc agg gcc aag ttc gtg ggg aca cca gaa gtc aac cag acc acc      320
 Val Ile Arg Ala Lys Phe Val Gly Thr Pro Glu Val Asn Gln Thr Thr
      35                  40                  45

 tta tac cag cgt tat gag atc aag atg acc aag atg tat aaa ggg ttc      368
 Leu Tyr Gln Arg Tyr Glu Ile Lys Met Thr Lys Met Tyr Lys Gly Phe
  50                  55                  60                  65

 caa gcc tta ggg gat gcc gct gac atc cgg ttc gtc tac acc ccc gcc      416
 Gln Ala Leu Gly Asp Ala Ala Asp Ile Arg Phe Val Tyr Thr Pro Ala
                  70                  75                  80

 atg gaa agt gtc tgc gga tac ttc cac agg tcc cac aac cgc agc gag      464
 Met Glu Ser Val Cys Gly Tyr Phe His Arg Ser His Asn Arg Ser Glu
              85                  90                  95

 gag ttt ctc att gct gga aaa ctg cag gat gga ctc ttg cac atc act      512
 Glu Phe Leu Ile Ala Gly Lys Leu Gln Asp Gly Leu Leu His Ile Thr
         100                 105                 110

 acc tgc agt ttg tgg ctc cct gga aca gcc tga gcttagct cagcgccggg      563
 Thr Cys Ser Leu Trp Leu Pro Gly Thr Ala 
     115                 120

 gcttcaccaa gacctacact gttggctggg aggaatgcac agtgtttccc tgtttatcca    623

 tcccctgcaa actgcagagt ggcactcatt gcttgtggac ggaccagctc ctccaaggct    683

 ctgaaaaggg cttacagtcc cgtcaccttg cctgcctgct cgggagccag ggctgtgcac    743

 ctggcagtcc ctgcggtccc agatagcctg aatcctgccg gagtggaagc tgaaggcctg    803

 caccaggtgt tccaccctgt ttcccactcc catctttctt ccggacaatg aatttacgag    863

 ttaccaccc                                                            872




      <210> 107
      <211> 1816
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (180)..(1046)

      <400> 107
 ccgcacgagg gaaagaacat taggaatgcc ttttagtgcc ttgcttcctg aactagctca     60

 cagtagcccg gcggcccagg gcaatccgac cacatttcac tctcaccgct gtaggaatcc    120

 agatgcaggc caagtacagc agcacgaggg acatgctgga tgatgatggg gacaccacc     179                                                                 
 atg agc ctg cat tct caa gcc tct gcc aca act cgg cat cca gag ccc      227
 Met Ser Leu His Ser Gln Ala Ser Ala Thr Thr Arg His Pro Glu Pro
   1               5                  10                  15

 cgg cgc aca gag cac agg gct ccc tct tca acg tgg cga cca gtg gcc      275
 Arg Arg Thr Glu His Arg Ala Pro Ser Ser Thr Trp Arg Pro Val Ala
              20                  25                  30

 ctg acc ctg ctg act ttg tgc ttg gtg ctg ctg ata ggg ctg gca gcc      323
 Leu Thr Leu Leu Thr Leu Cys Leu Val Leu Leu Ile Gly Leu Ala Ala
          35                  40                  45

 ctg ggg ctt ttg ttt ttt cag tac tac cag ctc tcc aat act ggt caa      371
 Leu Gly Leu Leu Phe Phe Gln Tyr Tyr Gln Leu Ser Asn Thr Gly Gln
      50                  55                  60

 gac acc att tct caa atg gaa gaa aga tta gga aat acg tcc caa gag      419
 Asp Thr Ile Ser Gln Met Glu Glu Arg Leu Gly Asn Thr Ser Gln Glu
  65                  70                  75                  80

 ttg caa tct ctt caa gtc cag aat ata aag ctt gca gga agt ctg cag      467
 Leu Gln Ser Leu Gln Val Gln Asn Ile Lys Leu Ala Gly Ser Leu Gln
                  85                  90                  95

 cat gtg gct gaa aaa ctc tgt cgt gag ctg tat aac aaa gct gga ggc      515
 His Val Ala Glu Lys Leu Cys Arg Glu Leu Tyr Asn Lys Ala Gly Gly
             100                 105                 110

 tat aca aga aac atg gtg cca gca tct gct tct tct gag agc ctc agg      563
 Tyr Thr Arg Asn Met Val Pro Ala Ser Ala Ser Ser Glu Ser Leu Arg
         115                 120                 125

 cag ctt cca cac atg ggg gaa agt gca gca gca cac agg tgc agc cct      611
 Gln Leu Pro His Met Gly Glu Ser Ala Ala Ala His Arg Cys Ser Pro
     130                 135                 140

 tgt aca gaa caa tgg aaa tgg cat gga gac aat tgc tac cag ttc tat      659
 Cys Thr Glu Gln Trp Lys Trp His Gly Asp Asn Cys Tyr Gln Phe Tyr
 145                 150                 155                 160

 aaa gac agc aaa agt tgg gag gac tgt aaa tat ttc tgc ctt agt gaa      707
 Lys Asp Ser Lys Ser Trp Glu Asp Cys Lys Tyr Phe Cys Leu Ser Glu
                 165                 170                 175

 aac tct acc atg ctg aag ata aac aaa caa gaa gac ctg gaa ttt gcc      755
 Asn Ser Thr Met Leu Lys Ile Asn Lys Gln Glu Asp Leu Glu Phe Ala
             180                 185                 190

 gcg tct cag agc tac tct gag ttt ttc tac tct tat tgg aca ggg ctt      803
 Ala Ser Gln Ser Tyr Ser Glu Phe Phe Tyr Ser Tyr Trp Thr Gly Leu
         195                 200                 205

 ttg cgc cct gac agt ggc aag gcc tgg ctg tgg atg gat gga acc cct      851
 Leu Arg Pro Asp Ser Gly Lys Ala Trp Leu Trp Met Asp Gly Thr Pro
     210                 215                 220

 ttc act tct gaa ctg ttc cat att ata ata gat gtc acc agc cca aga      899
 Phe Thr Ser Glu Leu Phe His Ile Ile Ile Asp Val Thr Ser Pro Arg
 225                 230                 235                 240

 agc aga gac tgt gtg gcc atc ctt aat ggg atg atc ttc tca aag gac      947
 Ser Arg Asp Cys Val Ala Ile Leu Asn Gly Met Ile Phe Ser Lys Asp
                 245                 250                 255

 tgc aaa gaa ttg aag cgt tgt gtc tgt gag aga agg gca gga atg gtg      995
 Cys Lys Glu Leu Lys Arg Cys Val Cys Glu Arg Arg Ala Gly Met Val
             260                 265                 270

 aag cca gag agc ctc cat gtc ccc cct gaa aca tta ggc gaa ggt gac     1043
 Lys Pro Glu Ser Leu His Val Pro Pro Glu Thr Leu Gly Glu Gly Asp
         275                 280                 285

 tga ttcg ccctctgcaa ctacaaatag cagagtgagc caggcggtgc caaagcaagg     1100
 


 gctagttgag acattgggaa atggaacata atcaggaaag actatctctc tgactagtac   1160

 aaaatgggtt ctcgtgtttc ctgttcagga tcaccagcat ttctgagctt gggtttatgc   1220

 acgtatttaa cagtcacaag aagtcttatt tacatgccac caaccaacct cagaaaccca   1280

 taatgtcatc tgccttcttg gcttagagat aacttttagc tctctttctt ctcaatgtct   1340

 aatatcacct ccctgttttc atgtcttcct tacacttggt ggaataagaa actttttgaa   1400

 gtagaggaaa tacattgagg taacatcctt ttctctgaca gtcaagtagt ccatcagaaa   1460

 ttggcagtca cttcccagat tgtaccagca aatacacaag gaattctttt tgtttgtttc   1520

 agttcatact agtcccttcc caatccatca gtaaagaccc catctgcctt gtccatgccg   1580

 tttcccaaca gggatgtcac ttgatatgag aatctcaaat ctcaatgcct tataagcatt   1640

 ccttcctgtg tccattaaga ctctgataat tgtctcccct ccataggaat ttctcccagg   1700

 aaagaaatat atccccatct ccgtttcata tcagaactac cgtccccgat attcccttca   1760

 gagagattaa agaccagaaa aaaggggggc tttttttttg cacctgtaat agtttc       1816




      <210> 108
      <211> 2408
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (218)..(1567)

      <400> 108
 tttcgtggta tttctgctcc tgcagctctt ctgtgttggc tgtggattct gtgggaaagt     60

 cctggtgtgg ccctgtgaca tgagccattg gcttaatgtc aaggtcattc tagaagagct    120

 catagtgaga ggccatgagg taacagtatt gactcactca aagccttcgt taattgacta    180

 caggaagcct tctgcattga aatttgaggt ggtccat atg cca cag gac aga aca     235
                                          Met Pro Gln Asp Arg Thr
                                            1               5

 gaa gaa aat gaa ata ttt gtt gac cta gct ctg aat gtc ttg cca ggc      283
 Glu Glu Asn Glu Ile Phe Val Asp Leu Ala Leu Asn Val Leu Pro Gly
              10                  15                  20

 tta tca acc tgg caa tca gtt ata aaa tta aat gat ttt ttt gtt gaa      331
 Leu Ser Thr Trp Gln Ser Val Ile Lys Leu Asn Asp Phe Phe Val Glu
          25                  30                  35

 ata aga gga act tta aaa atg atg tgt gag agc ttt atc tac aat cag      379
 Ile Arg Gly Thr Leu Lys Met Met Cys Glu Ser Phe Ile Tyr Asn Gln
      40                  45                  50

 acg ctt atg aag aag cta cag gaa acc aac tac gat gta atg ctt ata      427
 Thr Leu Met Lys Lys Leu Gln Glu Thr Asn Tyr Asp Val Met Leu Ile
  55                  60                  65                  70

 gac cct gtg att ccc tgt gga gac ctg atg gct gag ttg ctt gca gtc      475
 Asp Pro Val Ile Pro Cys Gly Asp Leu Met Ala Glu Leu Leu Ala Val
                  75                  80                  85

 cct ttt gtg ctc aca ctt aga att tct gta gga ggc aat atg gag cga      523
 Pro Phe Val Leu Thr Leu Arg Ile Ser Val Gly Gly Asn Met Glu Arg
              90                  95                 100

 agc tgt ggg aaa ctt cca gct cca ctt tcc tat gta ccc gtg cct atg      571
 Ser Cys Gly Lys Leu Pro Ala Pro Leu Ser Tyr Val Pro Val Pro Met
         105                 110                 115

 aca gga cta aca gac aga atg acc ttt ctg gaa aga gta aaa aat tca      619
 Thr Gly Leu Thr Asp Arg Met Thr Phe Leu Glu Arg Val Lys Asn Ser
     120                 125                 130

 atg ctt tca gtt ttg ttc cac ttc tgg att cag gat tac gac tat cat      667
 Met Leu Ser Val Leu Phe His Phe Trp Ile Gln Asp Tyr Asp Tyr His
 135                 140                 145                 150

 ttt tgg gaa gag ttt tat agt aag gca tta gga agg ccc act aca tta      715
 Phe Trp Glu Glu Phe Tyr Ser Lys Ala Leu Gly Arg Pro Thr Thr Leu
                 155                 160                 165

 tgt gag act gtg gga aaa gct gag ata tgg cta ata cga aca tat tgg      763
 Cys Glu Thr Val Gly Lys Ala Glu Ile Trp Leu Ile Arg Thr Tyr Trp
             170                 175                 180

 gat ttt gaa ttt cct caa cca tac caa cct aac ttt gag ttt gtt gga      811
 Asp Phe Glu Phe Pro Gln Pro Tyr Gln Pro Asn Phe Glu Phe Val Gly
         185                 190                 195

 gga ttg cac tgt aaa cct gcc aaa gct ttg cct aag gaa atg gaa aat      859
 Gly Leu His Cys Lys Pro Ala Lys Ala Leu Pro Lys Glu Met Glu Asn
     200                 205                 210

 ttt gtc cag agt tca ggg gaa gat ggt att gtg gtg ttt tct ctg ggg      907
 Phe Val Gln Ser Ser Gly Glu Asp Gly Ile Val Val Phe Ser Leu Gly
 215                 220                 225                 230

 tca ctg ttt caa aat gtt aca gaa gaa aag gct aat atc att gct tca      955
 Ser Leu Phe Gln Asn Val Thr Glu Glu Lys Ala Asn Ile Ile Ala Ser
                 235                 240                 245

 gcc ctt gcc cag atc cca cag aag gtg tta tgg agg tac aaa gga aaa     1003
 Ala Leu Ala Gln Ile Pro Gln Lys Val Leu Trp Arg Tyr Lys Gly Lys
             250                 255                 260

 aaa cca tcc aca tta gga gcc aat act cgg ctg tat gat tgg ata ccc     1051
 Lys Pro Ser Thr Leu Gly Ala Asn Thr Arg Leu Tyr Asp Trp Ile Pro
         265                 270                 275

 cag aat gat ctt ctt ggt cat ccc aaa acc aaa gct ttt atc act cat     1099
 Gln Asn Asp Leu Leu Gly His Pro Lys Thr Lys Ala Phe Ile Thr His
     280                 285                 290

 ggt gga atg aat ggg atc tat gaa gct att tac cat ggg gtc cct atg     1147
 Gly Gly Met Asn Gly Ile Tyr Glu Ala Ile Tyr His Gly Val Pro Met
 295                 300                 305                 310

 gtg gga gtt ccc ata ttt ggt gat cag ctt gat aac ata gct cac atg     1195
 Val Gly Val Pro Ile Phe Gly Asp Gln Leu Asp Asn Ile Ala His Met
                 315                 320                 325

 aag gcc aaa gga gca gct gta gaa ata aac ttc aaa act atg aca agc     1243
 Lys Ala Lys Gly Ala Ala Val Glu Ile Asn Phe Lys Thr Met Thr Ser
             330                 335                 340

 gaa gat tta ctg agg gct ttg aga aca gtc att acc gat tcc tct tat     1291
 Glu Asp Leu Leu Arg Ala Leu Arg Thr Val Ile Thr Asp Ser Ser Tyr
         345                 350                 355

 aaa gag aat gct atg aga tta tca aga att cac cat gat caa cct gta     1339
 Lys Glu Asn Ala Met Arg Leu Ser Arg Ile His His Asp Gln Pro Val
     360                 365                 370

 aag ccc cta gat cga gca gtc ttc tgg atc gag ttt gtc atg cgc cac     1387
 Lys Pro Leu Asp Arg Ala Val Phe Trp Ile Glu Phe Val Met Arg His
 375                 380                 385                 390

 aaa gga gcc aag cac ctg cga tca gct gcc cat gac ctc acc tgg ttc     1435
 Lys Gly Ala Lys His Leu Arg Ser Ala Ala His Asp Leu Thr Trp Phe
                 395                 400                 405

 cag cac tac tct ata gat gtg att ggg ttc ctg ctg acc tgt gtg gca     1483
 Gln His Tyr Ser Ile Asp Val Ile Gly Phe Leu Leu Thr Cys Val Ala
             410                 415                 420

 act gct ata ttc ttg ttc aca aaa tgt ttt tta ttt tcc tgt caa aaa     1531
 Thr Ala Ile Phe Leu Phe Thr Lys Cys Phe Leu Phe Ser Cys Gln Lys
         425                 430                 435

 ttt aat aaa act aga aag ata gaa aag agg gaa tag atct ttccaaattc     1581
 Phe Asn Lys Thr Arg Lys Ile Glu Lys Arg Glu 
     440                 445

 aagaaagacc tgatggggta atcctgttaa ttccagccac atagaatttg gtgaaaacct   1641

 tgctattttc atattatcta ttctgttatt ttatcttagc tatatagcct agaattccat   1701

 gatcatgagg ttgtgagtat atctcattct ttcgttgtat tttcctaggt gtctttactc   1761

 tcttctctca ctttgtgaca caaggacatg aatacatcta aattttccta tttctgatat   1821

 gactgttttg atgatgtcat tacttctata accttaagtg atagggtgac atgcaatatg   1881

 attattcctg gtgtgcgccc aaacacatgg atataaagag gtaaaaaact taaaattcac   1941

 aaaattcagt aaaccacaca aatcaggtaa gtgttctatg agattagctg gctatgagaa   2001

 acataatgat gtttcttttt caatttaaat aagcctttct acatagccag catcagtgat   2061

 ctcagaaaat aaattgctaa taatgatgac atggcattat gcttagaaaa gtttgctata   2121

 tttccaacat acctcatcta gatgtcatgg cctactattt ctgccatcac tcaagcaaca   2181

 tttttctgtg tgctcttgat gatacaatag accagtccgt caaattacta acaagaacac   2241

 tacatacatc tctttacata gccgaaaatg tcgataagat attccagggt aacccagcag   2301

 tcattctgac gatacggtac cattagaact tatgtggtta aatgctgatt ttataaaatt   2361

 ctaggtctga tggtcactta ctaaacacaa catttacatg cctattc                 2408




      <210> 109
      <211> 1385
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (391)..(912)

      <400> 109
 gtcttgccct caggaggaag ctggacgggc aggccggggt gctcccacct ggtgattggt     60

 gcgcaggctg tccatctgct tctggaacac cgccacccac aggtctttgc acaagaactt    120

 gaggacatcc agctcctccc tgaaggccag cgtctcccgg ggcagcctgg tggggcagta    180

 ccaagctgaa gccgtggggc caggccagga atagggagga agacaggccc gactcctgca    240

 tggagcaatg caaccctccc cgcccggggc ctgcccagcc ctgccagcca tgctggggga    300

 tagcatgagg ggccgctctc acctctcgcc tagagcctgg cccacacgga accccatacc    360

 ctccaggacc gacaggctca tcttctgtcc     atg gcg gat act gtg ttg ttt     411
                                      Met Ala Asp Thr Val Leu Phe
                                        1               5

 gag ttt ctt cac acg gag atg gtg gct gag ctg tgg gct cac gac ccc      459
 Glu Phe Leu His Thr Glu Met Val Ala Glu Leu Trp Ala His Asp Pro
          10                  15                  20

 gac ccc ggc ccg ggg gtg agc gcc ggg ctc cgt ggg gag gaa gcg ggg      507
 Asp Pro Gly Pro Gly Val Ser Ala Gly Leu Arg Gly Glu Glu Ala Gly
      25                  30                  35

 gcc acc aag gga cag aag atg agc ctg tcg gtc ctg gag ggt atg ggg      555
 Ala Thr Lys Gly Gln Lys Met Ser Leu Ser Val Leu Glu Gly Met Gly
  40                  45                  50                  55

 ttc cgt gtg ggc cag gct cta ggc gag agg ctg ccc cgg gag acg ctg      603
 Phe Arg Val Gly Gln Ala Leu Gly Glu Arg Leu Pro Arg Glu Thr Leu
                  60                  65                  70

 gcc ttc agg gag gag ctg gat gtc ctc aag ttc ttg tgc aaa gac ctg      651
 Ala Phe Arg Glu Glu Leu Asp Val Leu Lys Phe Leu Cys Lys Asp Leu
              75                  80                  85

 tgg gtg gcg gtg ttc cag aag cag atg gac agc ctg cgc acc aat cac      699
 Trp Val Ala Val Phe Gln Lys Gln Met Asp Ser Leu Arg Thr Asn His
          90                  95                 100

 cag ggg acc tac gtc ctg caa gac aac agc ttc ccc ctc ctc ctc ccg      747
 Gln Gly Thr Tyr Val Leu Gln Asp Asn Ser Phe Pro Leu Leu Leu Pro
     105                 110                 115

 atg gcc tct ggc ctg cag tat ctg gag gaa gca ccc aag ttc ctg gcc      795
 Met Ala Ser Gly Leu Gln Tyr Leu Glu Glu Ala Pro Lys Phe Leu Ala
 120                 125                 130                 135

 ttc acc tgc ggc ctc ctg cgc ggc gcc ctc tat acc ctg ggc att gag      843
 Phe Thr Cys Gly Leu Leu Arg Gly Ala Leu Tyr Thr Leu Gly Ile Glu
                 140                 145                 150

 agc gtg gtc acc gcc tcc gtg gca gcc ctg ccc gtc tgt aag ttc cag      891
 Ser Val Val Thr Ala Ser Val Ala Ala Leu Pro Val Cys Lys Phe Gln
             155                 160                 165

 gtg gtg att ccg aaa tcc taa gc ctgcctcgca cctgctgagc cgcactgctg      944
 Val Val Ile Pro Lys Ser 
         170

 cccctggcct caccggcctc aggagacggt ggggccgctg catttcgggg tggtcttggg   1004

 aatcccaggc cctaggggtc acatttgctc aggaagtggg tatcaaattg aggtgggggt   1064

 gtcagaggag gcaaaggggt cccagctgcg gtcaggactg tggtgggatt cccgcctcgg   1124

 cagcgtcact gcccagtagc tgctcaataa aggctgtgtg tgtggaaaca cacagcgggg   1184

 tcgggaaagg gtccgttttc atggaccgga aaaccagaaa ttcgaaacgg ggccctctgg   1244

 ggcataaaac cggaaaggcc gccaaggtgc ttcaacacgc tcgaaaggca caaggacacg   1304

 acaggcgtgg cgtcgccacg gcgcaatggc acaggtgtcg aaccatccgg cacccacaca   1364

 tcgcgacccc agaggaacgc g                                             1385




      <210> 110
      <211> 1709
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (50)..(1177)

      <400> 110
 cggacgcgtg ggcagagagt gcgcgccctg agtcgcaggc cgaggagac    atg gct      55
                                                          Met Ala
                                                            1

 gca ctt cgt gac gct gag ata cag aag gac gtg cag acc tac tac ggg      103
 Ala Leu Arg Asp Ala Glu Ile Gln Lys Asp Val Gln Thr Tyr Tyr Gly
           5                  10                  15

 cag gtg ctg aag aga tcg gca gac ctc cag acc aac ggc tgt gtc acc      151
 Gln Val Leu Lys Arg Ser Ala Asp Leu Gln Thr Asn Gly Cys Val Thr
      20                  25                  30

 aca gcc agg ccg gtc ccc aag cac atc cgg gaa gcc ttg caa aat gta      199
 Thr Ala Arg Pro Val Pro Lys His Ile Arg Glu Ala Leu Gln Asn Val
  35                  40                  45                  50

 cac gaa gaa gta gcc cta aga tat tat ggc tgt ggt ctg gtg atc cct      247
 His Glu Glu Val Ala Leu Arg Tyr Tyr Gly Cys Gly Leu Val Ile Pro
                  55                  60                  65

 gag cat cta gaa aac tgc tgg att ttg gat ctg ggt agt gga agt ggc      295
 Glu His Leu Glu Asn Cys Trp Ile Leu Asp Leu Gly Ser Gly Ser Gly
              70                  75                  80

 aga gat tgc tat gta ctt agc cag ctg gtt ggt gaa aaa gga cac gtg      343
 Arg Asp Cys Tyr Val Leu Ser Gln Leu Val Gly Glu Lys Gly His Val
          85                  90                  95

 act gga ata gac atg acc aaa ggc cag gtg gaa gtg gct gaa aag tat      391
 Thr Gly Ile Asp Met Thr Lys Gly Gln Val Glu Val Ala Glu Lys Tyr
     100                 105                 110

 ctt gac tat cac atg gaa aaa tat ggc ttc cag gca tct aat gtg act      439
 Leu Asp Tyr His Met Glu Lys Tyr Gly Phe Gln Ala Ser Asn Val Thr
 115                 120                 125                 130

 ttt att cat ggc tac att gag aag ttg gga gag gct gga atc aag aat      487
 Phe Ile His Gly Tyr Ile Glu Lys Leu Gly Glu Ala Gly Ile Lys Asn
                 135                 140                 145

 gag agc cat gat att gtt gta tca aac tgt gtt att aac ctt gtg cct      535
 Glu Ser His Asp Ile Val Val Ser Asn Cys Val Ile Asn Leu Val Pro
             150                 155                 160

 gat aaa caa caa gtg ctt cag gag gca tat cgg gtg ctg aag cat ggt      583
 Asp Lys Gln Gln Val Leu Gln Glu Ala Tyr Arg Val Leu Lys His Gly
         165                 170                 175

 ggg gag tta tat ttc agt gac gtc tat acg agc ctt gaa ctg cca gaa      631
 Gly Glu Leu Tyr Phe Ser Asp Val Tyr Thr Ser Leu Glu Leu Pro Glu
     180                 185                 190

 gaa atc agg aca cac aaa gtt tta tgg ggt gag tgt ctg ggt ggt gct      679
 Glu Ile Arg Thr His Lys Val Leu Trp Gly Glu Cys Leu Gly Gly Ala
 195                 200                 205                 210

 tta tac tgg aag gaa ctt gct gtc ctt gct caa aaa att ggg ttc tgc      727
 Leu Tyr Trp Lys Glu Leu Ala Val Leu Ala Gln Lys Ile Gly Phe Cys
                 215                 220                 225

 cct cca cgt ttg gtc act gcc aat ctc att aca att caa aac aag gaa      775
 Pro Pro Arg Leu Val Thr Ala Asn Leu Ile Thr Ile Gln Asn Lys Glu
             230                 235                 240

 ctg gaa aga gtt atc ggt gac tgt cgt ttt gtt tct gca aca ttt cgc      823
 Leu Glu Arg Val Ile Gly Asp Cys Arg Phe Val Ser Ala Thr Phe Arg
         245                 250                 255

 ctc ttc aaa cac tct aag aca gga cca acc aag aga tgc caa gtt att      871
 Leu Phe Lys His Ser Lys Thr Gly Pro Thr Lys Arg Cys Gln Val Ile
     260                 265                 270

 tac aat gga gga att aca gga cat gaa aaa gaa cta atg ttt gat gcc      919
 Tyr Asn Gly Gly Ile Thr Gly His Glu Lys Glu Leu Met Phe Asp Ala
 275                 280                 285                 290

 aat ttt aca ttt aag gaa ggt gaa att gtt gaa gtg gat gaa gaa aca      967
 Asn Phe Thr Phe Lys Glu Gly Glu Ile Val Glu Val Asp Glu Glu Thr
                 295                 300                 305

 gca gct atc ttg aag aat tca aga ttt gct caa gat ttt ctg atc aga     1015
 Ala Ala Ile Leu Lys Asn Ser Arg Phe Ala Gln Asp Phe Leu Ile Arg
             310                 315                 320

 cca att gga gag aag ttg cca aca tct gga ggc tgt tct gct ttg gag     1063
 Pro Ile Gly Glu Lys Leu Pro Thr Ser Gly Gly Cys Ser Ala Leu Glu
         325                 330                 335

 tta aag gat ata atc aca gat cca ttt aag ctt gca gaa gag tct gac     1111
 Leu Lys Asp Ile Ile Thr Asp Pro Phe Lys Leu Ala Glu Glu Ser Asp
     340                 345                 350

 agt atg aag tcc aga tgt gtc cct gat gct gct gga ggc tgc tgt ggc     1159
 Ser Met Lys Ser Arg Cys Val Pro Asp Ala Ala Gly Gly Cys Cys Gly
 355                 360                 365                 370

 aca aag aaa agc tgc taa atctat agccaaccag gggaccacag tagtgggcaa     1213
 Thr Lys Lys Ser Cys 
                 375

 gagtgatctg catgtttttt aacctgcttt tccccatagc acagaccata agaaacaaca   1273

 aatggagcca ctgcgcccgg ccataaatga attattttta agaggcattg attaaagatt   1333

 cacagcaaat cactagttaa gcagattttt tttctatttc ctacttcaaa gttctggtgc   1393

 cacatagtgg tcagaaatgg aacagagaag ctgtcttaag ccttgttcaa gaagcaggaa   1453

 aggcatcaga agaagtaaca gttggcagag ggtctcagga aaaacatctt ccttctgatc   1513

 ttttgcatag caccttctgg aattttcatc atgtttgctt attaaacaaa gctcctactg   1573

 ccatcatact aatcatgcaa aaagattgcc aaatcatgtt tggtaggagg acttttgagg   1633

 tagcttttga acaaatgttt ttttcttttt tctttttttt tgcaataaag aaaacaaatt   1693

 aatcataaaa aaaaaa                                                   1709




      <210> 111
      <211> 3595
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (628)..(2949)

      <400> 111
 cttttttctg agagattcaa agcctccacg actctgtttc ccccgtccct tctgaattta     60

 atttgcacta agtcatttgc actggttgga gttgtggaga cggccttgag tctcggtgcg    120

 agtgtgcgtg agtgtgagcc accttggcaa gtgcctgcgc agggcccggc cgccctccat    180

 ctgggccggg tgactgggcg ccggctgtgt gcccgaggcc tcaccctgcc ctcgcctagt    240

 ctggaagctc cgaccgacat cacggagcag ccttcaagca ttccattacg ccccatctcg    300

 ctctgtgccc ctccccacca gggcttcagc aggagccctg gactcatcat caataaacac    360

 tgttacagca aaaaaaaaaa aaaaaaactc gaacggtgta gaaccggggg agacgcagag    420

 agggcctccg gggaggacac aggaagactt ggggaacatg cacaggggcg aggctccccg    480

 ggcacaccga gaaagcgcgg cccggggccc agaggcgcag tctccgcaac ctcgaaggcc    540

 tatgccgcga acccgcactc gttcgtgttc acgcgaggct gcacgggtcg caacatccgg    600

 cagctcagcc tggacgtgcg gcgggtc    atg gag ccg ctc act gcc agc cgt     651
                                  Met Glu Pro Leu Thr Ala Ser Arg
                                    1               5

 ctg cag gtt cgt aag aag aac tcg ctg aag gac tgc gtg gca gtg gct      699
 Leu Gln Val Arg Lys Lys Asn Ser Leu Lys Asp Cys Val Ala Val Ala
      10                  15                  20

 ggg ccc ctc ggg gtc aca cac ttt ctg atc ctg agc aaa aca gag acc      747
 Gly Pro Leu Gly Val Thr His Phe Leu Ile Leu Ser Lys Thr Glu Thr
  25                  30                  35                  40

 aat gtc tac ttt aag ctg atg cgc ctc cca gga ggc ccc acc ttg acc      795
 Asn Val Tyr Phe Lys Leu Met Arg Leu Pro Gly Gly Pro Thr Leu Thr
                  45                  50                  55

 ttc cag gtc aag aag tac tcg ctg gtg cgt gat gtg gtc tcc tca ctg      843
 Phe Gln Val Lys Lys Tyr Ser Leu Val Arg Asp Val Val Ser Ser Leu
              60                  65                  70

 cgc cgg cac cgc atg cac gag cag cag ttt gcc cac cca ccc ctc ctg      891
 Arg Arg His Arg Met His Glu Gln Gln Phe Ala His Pro Pro Leu Leu
          75                  80                  85

 gta ctc aac agc ttt ggc ccc cat ggt atg cat gtg aag ctc atg gcc      939
 Val Leu Asn Ser Phe Gly Pro His Gly Met His Val Lys Leu Met Ala
      90                  95                 100

 acc atg ttc cag aac ctg ttc ccc tcc atc aac gtg cac aag gtg aac      987
 Thr Met Phe Gln Asn Leu Phe Pro Ser Ile Asn Val His Lys Val Asn
 105                 110                 115                 120

 ctg aac acc atc aag cgc tgc ctc ctc atc gac tac aac ccc gac tcc     1035
 Leu Asn Thr Ile Lys Arg Cys Leu Leu Ile Asp Tyr Asn Pro Asp Ser
                 125                 130                 135

 cag gag ctg gac ttc cgc cac tat agc atc aaa gtt gtt cct gtg ggc     1083
 Gln Glu Leu Asp Phe Arg His Tyr Ser Ile Lys Val Val Pro Val Gly
             140                 145                 150

 gcg agt cgc ggg atg aag aag ctg ctc cag gag aag ttc ccc aac atg     1131
 Ala Ser Arg Gly Met Lys Lys Leu Leu Gln Glu Lys Phe Pro Asn Met
         155                 160                 165

 agc cgc ctg cag gac atc agc gag ctg ctg gcc acg ggc gcg ggg ctg     1179
 Ser Arg Leu Gln Asp Ile Ser Glu Leu Leu Ala Thr Gly Ala Gly Leu
     170                 175                 180

 tcg gag agc gag gca gag cct gac ggc gac cac aac atc aca gag ctg     1227
 Ser Glu Ser Glu Ala Glu Pro Asp Gly Asp His Asn Ile Thr Glu Leu
 185                 190                 195                 200

 cct cag gct gtc gct ggc cgt ggc aac atg cgg gcc cag cag agt gca     1275
 Pro Gln Ala Val Ala Gly Arg Gly Asn Met Arg Ala Gln Gln Ser Ala
                 205                 210                 215

 gtg cgg ctc acc gag atc ggc ccg cgg atg aca ctg cag ctc atc aag     1323
 Val Arg Leu Thr Glu Ile Gly Pro Arg Met Thr Leu Gln Leu Ile Lys
             220                 225                 230

 gtc cag gag ggc gtc ggg gag ggc aaa gtg atg ttc cac agt ttt gtg     1371
 Val Gln Glu Gly Val Gly Glu Gly Lys Val Met Phe His Ser Phe Val
         235                 240                 245

 agc aag acg gag gag gag ctg cag gcc atc ctg gaa gcc aag gag aag     1419
 Ser Lys Thr Glu Glu Glu Leu Gln Ala Ile Leu Glu Ala Lys Glu Lys
     250                 255                 260

 aag ctg cgg ctg aag gcg cag agg cag gcc cag cag gcc cag aat gtg     1467
 Lys Leu Arg Leu Lys Ala Gln Arg Gln Ala Gln Gln Ala Gln Asn Val
 265                 270                 275                 280

 cag cgc aag cag gag cag cgg gag gcc cac aga aag aag agc ctg gag     1515
 Gln Arg Lys Gln Glu Gln Arg Glu Ala His Arg Lys Lys Ser Leu Glu
                 285                 290                 295

 ggc atg aag aag gca cgg gtc ggg ggt agt gat gaa gag gcc tct ggg     1563
 Gly Met Lys Lys Ala Arg Val Gly Gly Ser Asp Glu Glu Ala Ser Gly
             300                 305                 310

 atc cct tca agg acg gcg agc ctg gag ttg ggt gag gac gat gat gaa     1611
 Ile Pro Ser Arg Thr Ala Ser Leu Glu Leu Gly Glu Asp Asp Asp Glu
         315                 320                 325

 cag gaa gat gat gac atc gag tat ttc tgc cag gcg gtg ggc gag gcg     1659
 Gln Glu Asp Asp Asp Ile Glu Tyr Phe Cys Gln Ala Val Gly Glu Ala
     330                 335                 340

 ccc agt gag gac ctg ttc ccc gag gcc aag cag aaa cgg ctt gcc aag     1707
 Pro Ser Glu Asp Leu Phe Pro Glu Ala Lys Gln Lys Arg Leu Ala Lys
 345                 350                 355                 360

 tct cca ggg cgg aag cgg aag cgg tgg gaa atg gat cga ggc agg ggt     1755
 Ser Pro Gly Arg Lys Arg Lys Arg Trp Glu Met Asp Arg Gly Arg Gly
                 365                 370                 375

 cgc ctt tgt gac cag aag ttt ccc aag acc aag gac aag tcc cag gga     1803
 Arg Leu Cys Asp Gln Lys Phe Pro Lys Thr Lys Asp Lys Ser Gln Gly
             380                 385                 390

 gcc cag gcc agg cgg ggg ccc aga ggg gct tcc cgg gat ggt gcc aag     1851
 Ala Gln Ala Arg Arg Gly Pro Arg Gly Ala Ser Arg Asp Gly Ala Lys
         395                 400                 405

 tcc tgc cct gcc aac ttc ttg gca gct gcc gac gac aaa ctc agt ggg     1899
 Ser Cys Pro Ala Asn Phe Leu Ala Ala Ala Asp Asp Lys Leu Ser Gly
     410                 415                 420

 ttc cag ggg gac ttc ctg tgg ccc ata ctg gtg gtt gag ttc ctg gtg     1947
 Phe Gln Gly Asp Phe Leu Trp Pro Ile Leu Val Val Glu Phe Leu Val
 425                 430                 435                 440

 gcc gtg gcc agc aat ggc ctg gcc ctg tac cgc ttc agc atc cgg aag     1995
 Ala Val Ala Ser Asn Gly Leu Ala Leu Tyr Arg Phe Ser Ile Arg Lys
                 445                 450                 455

 cag cgc cca tgg cac ccc gcc gtg gtc ttc tct gtc cag ctg gca gtc     2043
 Gln Arg Pro Trp His Pro Ala Val Val Phe Ser Val Gln Leu Ala Val
             460                 465                 470

 agc gac ctg ctc tgc gcc ctg acg ctg ccc ccg ctg gcc gcc tac ctc     2091
 Ser Asp Leu Leu Cys Ala Leu Thr Leu Pro Pro Leu Ala Ala Tyr Leu
         475                 480                 485

 tat ccc ccc aag cac tgg cgc tat ggg gag gcc gcg tgc cgc ctg gag     2139
 Tyr Pro Pro Lys His Trp Arg Tyr Gly Glu Ala Ala Cys Arg Leu Glu
     490                 495                 500

 cgc ttc ctc ttc acc tgc aac ctg ctg ggc agc gtc atc ttc atc acc     2187
 Arg Phe Leu Phe Thr Cys Asn Leu Leu Gly Ser Val Ile Phe Ile Thr
 505                 510                 515                 520

 tgc atc agc ctc aac cgc tac ctg ggc atc gtg cac ccc ttc ttc gcc     2235
 Cys Ile Ser Leu Asn Arg Tyr Leu Gly Ile Val His Pro Phe Phe Ala
                 525                 530                 535

 cga agc cac ctg cga ccc aag cac gcc tgg gcc gtg agc gct gcc ggc     2283
 Arg Ser His Leu Arg Pro Lys His Ala Trp Ala Val Ser Ala Ala Gly
             540                 545                 550

 tgg gtc ctg gcc gcc ctg ctg gcc atg ccc aca ctc agc ttc tcc cac     2331
 Trp Val Leu Ala Ala Leu Leu Ala Met Pro Thr Leu Ser Phe Ser His
         555                 560                 565

 ctg aag agg ccg cag cag ggg gcg ggc aac tgc agc gtg gcc agg ccc     2379
 Leu Lys Arg Pro Gln Gln Gly Ala Gly Asn Cys Ser Val Ala Arg Pro
     570                 575                 580

 gag gcc tgc atc aag tgt ctg ggg aca gca gac cac ggg ctg gcg gcc     2427
 Glu Ala Cys Ile Lys Cys Leu Gly Thr Ala Asp His Gly Leu Ala Ala
 585                 590                 595                 600

 tac aga gcg tat agc ctg gtg ctg gcg ggg ttg ggc tgc ggc ctg ccg     2475
 Tyr Arg Ala Tyr Ser Leu Val Leu Ala Gly Leu Gly Cys Gly Leu Pro
                 605                 610                 615

 ctg ctg ctc acg ctg gca gcc tac ggc gcc ctc ggg cgg gcc gtg cta     2523
 Leu Leu Leu Thr Leu Ala Ala Tyr Gly Ala Leu Gly Arg Ala Val Leu
             620                 625                 630

 cgc agc cca ggc atg act gtg gcc gag aag ctg cgt gtg gca gcg ttg     2571
 Arg Ser Pro Gly Met Thr Val Ala Glu Lys Leu Arg Val Ala Ala Leu
         635                 640                 645

 gtg gcc agt ggt gtg gcc ctc tac gcc agc tcc tat gtg ccc tac cac     2619
 Val Ala Ser Gly Val Ala Leu Tyr Ala Ser Ser Tyr Val Pro Tyr His
     650                 655                 660

 atc atg cgg gtg ctc aac gtg gat gct cgg cgg cgc tgg agc acc cgc     2667
 Ile Met Arg Val Leu Asn Val Asp Ala Arg Arg Arg Trp Ser Thr Arg
 665                 670                 675                 680

 tgc ccg agc ttt gca gac ata gcc cag gcc aca gca gcc ctg gag ctg     2715
 Cys Pro Ser Phe Ala Asp Ile Ala Gln Ala Thr Ala Ala Leu Glu Leu
                 685                 690                 695

 ggg ccc tac gtg ggc tac cag gtg atg cgg ggc ctc atg ccc ctg gcc     2763
 Gly Pro Tyr Val Gly Tyr Gln Val Met Arg Gly Leu Met Pro Leu Ala
             700                 705                 710

 ttc tgt gtc cac cct cta ctc tac atg gcc gca gtg ccc agc ctg ggc     2811
 Phe Cys Val His Pro Leu Leu Tyr Met Ala Ala Val Pro Ser Leu Gly
         715                 720                 725

 tgc tgc tgc cga cac tgc ccc ggc tac agg gac agc tgg aac cca gag     2859
 Cys Cys Cys Arg His Cys Pro Gly Tyr Arg Asp Ser Trp Asn Pro Glu
     730                 735                 740

 gac gcc aag agc act ggc caa gcc ctg ccc ctc aat gcc aca gcc gcc     2907
 Asp Ala Lys Ser Thr Gly Gln Ala Leu Pro Leu Asn Ala Thr Ala Ala
 745                 750                 755                 760

 cct aaa ccg tca gag ccc cag tcc cgt gag ctg agc caa tga tgtggcc     2956
 Pro Lys Pro Ser Glu Pro Gln Ser Arg Glu Leu Ser Gln 
                 765                 770

 tagcggaagc tgcctcctca ccctaggtgt tgctggagaa ccctgagggc agggcccgag   3016

 ccccgacaca tcccttcccc caaaaagcaa cacctgtgct tgcagccagg tcaggcccag   3076

 ctgcagccca ggcaggagca gtcgcctttc ccacccacag cgctggccac agggctccct   3136

 gcagggtcag ggaccagacc acgcccagag gaggggaggc actggccccc gccacaggac   3196

 tggagacgca agaacaaaaa gaaccaagta gagagagtgg agctgcttta ttgcccttgg   3256

 agcccgcgct ctcggaggct gtcttctgtc gccaagggtc ccggaccgag tacacagtgg   3316

 cagctggctt agttggtgga cggcctgggg taggggaggg tggcaggtat aagacttctg   3376

 ggggcacccc aagaccccag acacccaagt ggcatcttgg gggtgggtgg gcagaggacg   3436

 gggtaatgtg aggacgaagc gggcacggag ccagatggcc agtctccagg cctggtccac   3496

 ggactggcag ggaccccagg cacaagagct gccacccctc tgcccggttt tggaaaaaaa   3556

 caataaagga ctgtcccctc aaaaccaaaa aaaaaaaaa                          3595




      <210> 112
      <211> 1377
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (108)..(596)

      <400> 112
 gaggaagttc aagggcgaga gtgagtacca gcagaaggct gggagtctgt agtttgttcc     60

 tgctgccagg ctccactgag gggaacgggg acctgtctga agagaag  atg ccc ctg     116
                                                      Met Pro Leu
                                                        1

 ctg aca ctc tac ctg ctc ctc ttc tgg ctc tca ggc tac tcc att gcc      164
 Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr Ser Ile Ala
       5                  10                  15

 act caa atc acc ggt cca aca aca gtg aat ggc ttg gag cgg ggc tcc      212
 Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu Arg Gly Ser
  20                  25                  30                  35

 ttg acc gtg cag tgt gtt tac aga tca ggc tgg gag acc tac ttg aag      260
 Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr Tyr Leu Lys
                  40                  45                  50

 tgg tgg tgt cga gga gct att tgg cgt gac tgc aag atc ctt gtt aaa      308
 Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile Leu Val Lys
              55                  60                  65

 acc agt ggg tca gag cag gag gtg aag agg gac cgg gtg tcc atc aag      356
 Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val Ser Ile Lys
          70                  75                  80

 gac aat cag aaa aac cgc acg ttc act gtg acc atg gag gat ctc atg      404
 Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu Asp Leu Met
      85                  90                  95

 aaa act gat gct gac act tac tgg tgt gga att gag aaa act gga aat      452
 Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys Thr Gly Asn
 100                 105                 110                 115

 gac ctt ggg gtc aca gtt caa gtg acc att gac cca gca cca gtc acc      500
 Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala Pro Val Thr
                 120                 125                 130

 caa gaa gaa act agc agc tcc cca act ctg acc ggc cac cac ttg gac      548
 Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His His Leu Asp
             135                 140                 145

 aac agg tac tgc agc ccc tgg agg gcg acc tct gct atg cag acc tga      596
 Asn Arg Tyr Cys Ser Pro Trp Arg Ala Thr Ser Ala Met Gln Thr 
         150                 155                 160

 ccctgcagct ggccggaacc tccccgcaaa aggctaccac gaagctttcc tctgcccagg    656

 ttgaccaggt ggaagtggaa tatgtcacca tggcttcctt gccgaaggag gacatttcct    716

 atgcatctct gaccttgggt gctgaggatc aggaaccgac ctactgcaac atgggccacc    776

 tcagtagcca cctccccggc aggggccctg aggagcccac ggaatacagc accatcagca    836

 ggccttagcc tgcactccag gctccttctt ggaccccagg ctgtgagcac actcctgcct    896

 catcgaccgt ctgccccctg ctcccctcat caggaccaac ccggggactg gtgcctctgc    956

 ctgatcagcc agcattgccc ctagctctgg gttgggcttg gggccaagtc tcagggggct   1016

 tctaggagtt ggggttttct aaacgtcccc tcctctccta catagttgag gagggggcta   1076

 gggatatgct ctggggcttt catgggaatg atgaagatga taatgaaaaa aatgttatca   1136

 ttattatcat gacggaccat tatcgtaata caatgaacgc ttaatttatt gcctacccac   1196

 atgttatggg cctgaataat ggccccccaa agaaaattgg gtcctaatcc tcagaaccgt   1256

 ggagtggtac cttctgggga cacagaggga aaggtccaca tgttaggaag ttgaaggctt   1316

 ttcaaaaaga aaggctgatc atggccgagg ccggtgggcc ccgaattacg ccccaagggg   1376

 c                                                                   1377




      <210> 113
      <211> 1804
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (280)..(768)

      <400> 113
 cccgggtcga ccatttcgtg gcaaaagtgg ctccaggtgc agaaggttgg agttcagtgg     60

 tgcgatctgg gttcactgca acctctgccg cctgggttca agtgattctc ctacctcggc    120

 ctcccgagtc actgggatta cagtctcttt cacccatggg aagtgactga aggaggaagt    180

 tcaagggcga gagtgagtac cagcagaagg ctgggagtct gtagtttgtt cctgctgcca    240

 ggctccactg aggggaacgg ggacctgtct gaagagaag   atg ccc ctg ctg aca     294
                                              Met Pro Leu Leu Thr
                                                1               5

 ctc tac ctg ctc ctc ttc tgg ctc tca ggc tac tcc att gcc act caa      342
 Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr Ser Ile Ala Thr Gln
                  10                  15                  20

 atc acc ggt cca aca aca gtg aat ggc ttg gag cgg ggc tcc ttg acc      390
 Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu Arg Gly Ser Leu Thr
              25                  30                  35

 gtg cag tgt gtt tac aga tca ggc tgg gag acc tac ttg aag tgg tgg      438
 Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr Tyr Leu Lys Trp Trp
          40                  45                  50

 tgt cga gga gct att tgg cgt gac tgc aag atc ctt gtt aaa acc agt      486
 Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile Leu Val Lys Thr Ser
      55                  60                  65

 ggg tca gag cag gag gtg aag agg gac cgg gtg tcc atc aag gac aat      534
 Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val Ser Ile Lys Asp Asn
  70                  75                  80                  85

 cag aaa aac cgc acg ttc act gtg acc atg gag gat ctc atg aaa act      582
 Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu Asp Leu Met Lys Thr
                  90                  95                 100

 gat gct gac act tac tgg tgt gga att gag aaa act gga aat gac ctt      630
 Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys Thr Gly Asn Asp Leu
             105                 110                 115

 ggg gtc aca gtt caa gtg acc att gac cca gca cca gtc acc caa gaa      678
 Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala Pro Val Thr Gln Glu
         120                 125                 130

 gaa act agc agc tcc cca act ctg acc ggc cac cac ttg gac aac agg      726
 Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His His Leu Asp Asn Arg
     135                 140                 145

 tac tgc agc ccc tgg agg gcg acc tct gct atg cag acc tga ccctgca      775
 Tyr Cys Ser Pro Trp Arg Ala Thr Ser Ala Met Gln Thr 
 150                 155                 160

 gctggccgga acctccccgc aaaaggctac cacgaagctt tcctctgccc aggttgacca    835

 ggtggaagtg gaatatgtca ccatggcttc cttgccgaag gaggacattt cctatgcatc    895

 tctgaccttg ggtgctgagg atcaggaacc gacctactgc aacatgggcc acctcagtag    955

 ccacctcccc ggcaggggcc ctgaggagcc cacggaatac agcaccatca gcaggcctta   1015

 gcctgcactc caggctcctt cttggacccc aggctgtgag cacactcctg cctcatcgac   1075

 cgtctgcccc ctgctcccct catcaggacc aacccgggga ctggtgcctc tgcctgatca   1135

 gccagcattg cccctagctc tgggttgggc ttggggccaa gtctcagggg gcttctagga   1195

 gttggggttt tctaaacgtc ccctcctctc ctacatagtt gaggaggggg ctagggatat   1255

 gctctggggc tttcatggga atgatgaaga tgataatgag aaaaatgtta tcattattat   1315

 catgaagtac cattatcgta atacaatgaa cctttattta ttgcctacca catgttatgg   1375

 gctgaataat ggcccccaaa gatatctgtg tcctaatcct cagaacctgt gactgttacc   1435

 ttctgtggca gaaagggaca gtgcagatgt atgtaagtta aggactttga gatagagagg   1495

 ttattcttgc tgattcaggt gggcccaaaa tatcaccaca agggtcctca taagaaagag   1555

 gccagaaggt caaagaggta gagacaaagt gatgatggaa gtggacgtgg gtgtgacgtg   1615

 agcaggggcc atgaatgccg cagccttcag atgccagaaa gggaaaggaa tggattcccc   1675

 tgcctggagc ctccaaaaga aaccagccct gcccacgcct tgacttgagc ccattgaaac   1735

 tgatcttgag ctcctggcct ccagaattgc aggagaataa atttgtgttg tttttaatga   1795

 aaaaaaaaa                                                           1804




      <210> 114
      <211> 1051
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (37)..(954)

      <400> 114
 tccactgagg ggaacgggga cctgtctgaa gagaag  atg ccc ctg ctg aca ctc      54
                                          Met Pro Leu Leu Thr Leu
                                            1               5

 tac ctg ctc ctc ttc tgg ctc tca ggc tac tcc att gcc act caa atc      102
 Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr Ser Ile Ala Thr Gln Ile
              10                  15                  20

 acc ggt cca aca aca gtg aat ggc ttg gag cgg ggc tcc ttg acc gtg      150
 Thr Gly Pro Thr Thr Val Asn Gly Leu Glu Arg Gly Ser Leu Thr Val
          25                  30                  35

 cag tgt gtt tac aga tca ggc tgg gag acc tac ttg aag tgg tgg tgt      198
 Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr Tyr Leu Lys Trp Trp Cys
      40                  45                  50

 cga gga gct att tgg cgt gac tgc aag atc ctt gtt aaa acc agt ggg      246
 Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile Leu Val Lys Thr Ser Gly
  55                  60                  65                  70

 tca gag cag gag gtg aag agg gac cgg gtg tcc atc aag gac aat cag      294
 Ser Glu Gln Glu Val Lys Arg Asp Arg Val Ser Ile Lys Asp Asn Gln
                  75                  80                  85

 aaa aac cgc acg ttc act gtg acc atg gag gat ctc atg aaa act gat      342
 Lys Asn Arg Thr Phe Thr Val Thr Met Glu Asp Leu Met Lys Thr Asp
              90                  95                 100

 gct gac act tac tgg tgt gga att gag aaa act gga aat gac ctt ggg      390
 Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys Thr Gly Asn Asp Leu Gly
         105                 110                 115

 gtc aca gtt caa gtg acc att gac cca gcg tcg act cct gcc ccc acc      438
 Val Thr Val Gln Val Thr Ile Asp Pro Ala Ser Thr Pro Ala Pro Thr
     120                 125                 130

 acg cct acc tcc act acg ttt aca gca cca gtc acc caa gaa gaa act      486
 Thr Pro Thr Ser Thr Thr Phe Thr Ala Pro Val Thr Gln Glu Glu Thr
 135                 140                 145                 150

 agc agc tcc cca act ctg acc ggc cac cac ttg gac aac agg cac aag      534
 Ser Ser Ser Pro Thr Leu Thr Gly His His Leu Asp Asn Arg His Lys
                 155                 160                 165

 ctc ctg aag ctc agt gtc ctc ctg ccc ctc atc ttc acc ata ttg ctg      582
 Leu Leu Lys Leu Ser Val Leu Leu Pro Leu Ile Phe Thr Ile Leu Leu
             170                 175                 180

 ctg ctt ttg gtg gcc gcc tca ctc ttg gct tgg agg atg atg aag tac      630
 Leu Leu Leu Val Ala Ala Ser Leu Leu Ala Trp Arg Met Met Lys Tyr
         185                 190                 195

 cag cag aaa gca gcc ggg atg tcc cca gag cag gta ctg cag ccc ctg      678
 Gln Gln Lys Ala Ala Gly Met Ser Pro Glu Gln Val Leu Gln Pro Leu
     200                 205                 210

 gag ggc gac ctc tgc tat gca gac ctg acc ctg cag ctg gcc gga acc      726
 Glu Gly Asp Leu Cys Tyr Ala Asp Leu Thr Leu Gln Leu Ala Gly Thr
 215                 220                 225                 230

 tcc ccg caa aag gct acc acg aag ctt tcc tct gcc cag gtt gac cag      774
 Ser Pro Gln Lys Ala Thr Thr Lys Leu Ser Ser Ala Gln Val Asp Gln
                 235                 240                 245

 gtg gaa gtg gaa tat gtc acc atg gct tcc ttg ccg aag gag gac att      822
 Val Glu Val Glu Tyr Val Thr Met Ala Ser Leu Pro Lys Glu Asp Ile
             250                 255                 260

 tcc tat gca tct ctg acc ttg ggt gct gag gat cag gaa ccg acc tac      870
 Ser Tyr Ala Ser Leu Thr Leu Gly Ala Glu Asp Gln Glu Pro Thr Tyr
         265                 270                 275

 tgc aac atg ggc cac ctc agt agc cac ctc ccc ggc agg ggc cct gag      918
 Cys Asn Met Gly His Leu Ser Ser His Leu Pro Gly Arg Gly Pro Glu
     280                 285                 290

 gag ccc acg gaa tac agc acc atc agc agg cct tag cctg cactccaggc      968
 Glu Pro Thr Glu Tyr Ser Thr Ile Ser Arg Pro 
 295                 300                 305

 tccttcttgg accccaggct gtgagcacac tcctgcctca tcgaccgtct gccccctgct   1028

 cccttaataa ggaccacccg gga                                           1051




      <210> 115
      <211> 1835
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (234)..(1463)

      <400> 115
 attgattcta attagcacat tttgtgcctc agctagtagc tccccgttaa gctctgcctg     60

 gagagttttt ttttagattc catcctgctc ataaacactg ccacctcctc cctccttctc    120

 tctttacaaa tgttacaaca caatcagaaa tttcctcttt tctttccttc ctgcattttc    180

 agcaggttcc cttgcgtcag aagcccagga ggaaaactca aggttttctc acg   atg     236
                                                              Met
                                                                1

 agt cgg agg agg ata tcg tgt aaa gat ctg ggc cat gct gac tgc caa      284
 Ser Arg Arg Arg Ile Ser Cys Lys Asp Leu Gly His Ala Asp Cys Gln
               5                  10                  15

 ggg tgg ctg tat aag aaa aag gaa aag gga agt ttc cta agc aac aaa      332
 Gly Trp Leu Tyr Lys Lys Lys Glu Lys Gly Ser Phe Leu Ser Asn Lys
          20                  25                  30

 tgg aaa aag ttc tgg gtg ata ctg aag ggg tcg tca ctg tac tgg tat      380
 Trp Lys Lys Phe Trp Val Ile Leu Lys Gly Ser Ser Leu Tyr Trp Tyr
      35                  40                  45

 agc aat caa atg gca gag aaa gct gat gga ttt gtc aac ctg cct gat      428
 Ser Asn Gln Met Ala Glu Lys Ala Asp Gly Phe Val Asn Leu Pro Asp
  50                  55                  60                  65

 ttc act gtg gaa aga gca tct gaa tgc aag aaa aag cat gct ttt aag      476
 Phe Thr Val Glu Arg Ala Ser Glu Cys Lys Lys Lys His Ala Phe Lys
                  70                  75                  80

 atc agc cat cca cag atc aag acc ttt tat ttt gca gct gag aat gtg      524
 Ile Ser His Pro Gln Ile Lys Thr Phe Tyr Phe Ala Ala Glu Asn Val
              85                  90                  95

 cag gaa atg aac gtg tgg tta aat aaa ctt gga tcg gct gta atc cat      572
 Gln Glu Met Asn Val Trp Leu Asn Lys Leu Gly Ser Ala Val Ile His
         100                 105                 110

 cag gaa tcc act aca aag gat gaa gaa tgt tac agt gaa agt gaa cag      620
 Gln Glu Ser Thr Thr Lys Asp Glu Glu Cys Tyr Ser Glu Ser Glu Gln
     115                 120                 125

 gaa gat cca gaa ata gct gcg gag aca cca ccc cct cct cac gct tcc      668
 Glu Asp Pro Glu Ile Ala Ala Glu Thr Pro Pro Pro Pro His Ala Ser
 130                 135                 140                 145

 cag act cag tct ttg act gca cag cag gca tct tca tcc tca ccc agc      716
 Gln Thr Gln Ser Leu Thr Ala Gln Gln Ala Ser Ser Ser Ser Pro Ser
                 150                 155                 160

 ctg agt gga acg tcg tat tct ttc tct tcc ctg gaa aat aca gtg aag      764
 Leu Ser Gly Thr Ser Tyr Ser Phe Ser Ser Leu Glu Asn Thr Val Lys
             165                 170                 175

 aca ccc agc agt ttt cct tcc tcc tta tct aaa gag aga caa tcc ttg      812
 Thr Pro Ser Ser Phe Pro Ser Ser Leu Ser Lys Glu Arg Gln Ser Leu
         180                 185                 190

 cct gac aca gtt aac agt ttg tct gct gct gaa gat gag gga caa cca      860
 Pro Asp Thr Val Asn Ser Leu Ser Ala Ala Glu Asp Glu Gly Gln Pro
     195                 200                 205

 ata acg ttt gct gtg caa gtt cat tca cct gta ccc tca gag gca ggc      908
 Ile Thr Phe Ala Val Gln Val His Ser Pro Val Pro Ser Glu Ala Gly
 210                 215                 220                 225

 atc cac aag gcc ctg gaa aac agt ttt gtc aca tca gaa agt gga ttt      956
 Ile His Lys Ala Leu Glu Asn Ser Phe Val Thr Ser Glu Ser Gly Phe
                 230                 235                 240

 ttg aac tct tta tct agt gat gat act tct tca ttg agt agc aat cat     1004
 Leu Asn Ser Leu Ser Ser Asp Asp Thr Ser Ser Leu Ser Ser Asn His
             245                 250                 255

 gac cat ctt act gtc cca gat aag cct gct gga tca aag atc atg gac     1052
 Asp His Leu Thr Val Pro Asp Lys Pro Ala Gly Ser Lys Ile Met Asp
         260                 265                 270

 aaa gaa gag aca aaa gtg tct gaa gat gat gaa atg gag aag ctg tac     1100
 Lys Glu Glu Thr Lys Val Ser Glu Asp Asp Glu Met Glu Lys Leu Tyr
     275                 280                 285

 aaa tca tta gag caa gct agt cta tct cct ctt ggg gac cga cga cct     1148
 Lys Ser Leu Glu Gln Ala Ser Leu Ser Pro Leu Gly Asp Arg Arg Pro
 290                 295                 300                 305

 tcg act aaa aag gag ttg aga aaa tcc ttt gtt aag cgg tgt aaa aat     1196
 Ser Thr Lys Lys Glu Leu Arg Lys Ser Phe Val Lys Arg Cys Lys Asn
                 310                 315                 320

 cca tct ata aac gag aaa ctc cac aaa atc cga aca ttg aat agc aca     1244
 Pro Ser Ile Asn Glu Lys Leu His Lys Ile Arg Thr Leu Asn Ser Thr
             325                 330                 335

 tta aag tgt aaa gaa cat gat ctg gcc atg att aac cag ttg ctg gat     1292
 Leu Lys Cys Lys Glu His Asp Leu Ala Met Ile Asn Gln Leu Leu Asp
         340                 345                 350

 gac ccg aag ctg aca gcc agg aaa tac aga gag tgg aaa gtc atg aac     1340
 Asp Pro Lys Leu Thr Ala Arg Lys Tyr Arg Glu Trp Lys Val Met Asn
     355                 360                 365

 acc ctg ctg atc cag gac atc tat cag cag cag cgg gct tcg cct gcc     1388
 Thr Leu Leu Ile Gln Asp Ile Tyr Gln Gln Gln Arg Ala Ser Pro Ala
 370                 375                 380                 385

 cct gat gac act gat gac acc ccc cag gaa ctc aag aaa tca cct tct     1436
 Pro Asp Asp Thr Asp Asp Thr Pro Gln Glu Leu Lys Lys Ser Pro Ser
                 390                 395                 400

 tct ccc tct gtt gaa aat tcc att tga gacaa agtcagggtt ttctcctctt     1488
 Ser Pro Ser Val Glu Asn Ser Ile 
             405

 atattttatc acaagcaact cttcaagatg ttgcaaaagc ttacattttt ccttaaaagg   1548

 aaaactgaaa cccagtcctt caagcatcag cttcccatct aaagatgcac gttagatgaa   1608

 gataatcacc gaatacacca gggctcctca tttcagtcgt aacgcatcca ttgagattgg   1668

 aatgattgag ttcagttgaa aggcgttttt tgtgttccta ctgggagctc acggtgatgt   1728

 ggggctctag gggggatgtg agaaatgtct cttctgttca ttgctctcca gagaatgcta   1788

 tggacaagaa tcaaatttta ccaggagtaa ttgcccatgg aaacatt                 1835




      <210> 116
      <211> 631
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (156)..(437)

      <220>
      <221> misc_feature
      <222> (1)...(631)
      <223> n = a,t,c or g

      <400> 116
 ncaagattcg gcacgagggt gaaaatctgt gtgctccctc cggcgagaga ctttgtcagc     60

 tccagcacag taacatctga ataaagtcaa aactcaacta ccaggtggaa gtccaagaat    120

 ctgagtggag gctcaccgag gcgaaggggc caacc   atg gga aag gag agt gga     173
                                          Met Gly Lys Glu Ser Gly
                                            1               5

 tgg gac tca gtt gtg gct gtg ggg act gtg ctc gtg gcg ctc agt gcc      221
 Trp Asp Ser Val Val Ala Val Gly Thr Val Leu Val Ala Leu Ser Ala
              10                  15                  20

 atg ggc ttc acc tca gta gga atc gcc gca tcc tcc ata gca gcc aag      269
 Met Gly Phe Thr Ser Val Gly Ile Ala Ala Ser Ser Ile Ala Ala Lys
          25                  30                  35

 atg atg tct aca gca gcc att gcc aac ggg ggc gga gtt gct gct ggc      317
 Met Met Ser Thr Ala Ala Ile Ala Asn Gly Gly Gly Val Ala Ala Gly
      40                  45                  50

 agt ctg gtg gct att ctg cag tca gtg ggg gca gct gga ctc tct gtg      365
 Ser Leu Val Ala Ile Leu Gln Ser Val Gly Ala Ala Gly Leu Ser Val
  55                  60                  65                  70

 aca tct aaa gtt atc ggg ggc ttt gct ggg aca gct ctt ggg gcc tgg      413
 Thr Ser Lys Val Ile Gly Gly Phe Ala Gly Thr Ala Leu Gly Ala Trp
                  75                  80                  85

 ctg ggt tca ccc cct tcc agc tga acaccacact gaggcaggga gttggctctc     467
 Leu Gly Ser Pro Pro Ser Ser 
              90

 ttggtggaga tgactttcct gggcctctgg atgacaatct tccaaaggac aagtctccta    527

 ctcccaaaac tatttaagga agcatgaaaa ataaagatgc tggttatctt caaaaaaaaa    587

 aaaaaaaaac tcgagggggg gcaccggtac ccgaattcgc ccta                     631




      <210> 117
      <211> 793
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (324)..(641)

      <400> 117
 ctttactcct gccagcttgg gaaaaggccg gagaaggtga aattctgtgt gctccctccg     60

 gcgagagact ttgtcagctc ccgcacagta acgtggaagt ccaagaatcc gagtggaggc    120

 tcaccgaggc gaaggggcca accatgggaa aggagagtgg atgggactca ggaaggcttt    180

 tggcctgagc tgctgagagg atggattccg ggttcagcag tgacttgggc cagagcagag    240

 gcagagagac aagttaggaa gctcctccag tcatcccact gagagacgcg ggtggcttgg    300

 tccgggactg gagctgcaga agt    atg agg atg gtc aga ctg gat att tct     350
                              Met Arg Met Val Arg Leu Asp Ile Ser
                                1               5

 gaa ggc agg gct gct gta gca gct gtg gtc gga gga gtt gtg gct gtg      398
 Glu Gly Arg Ala Ala Val Ala Ala Val Val Gly Gly Val Val Ala Val
  10                  15                  20                  25

 ggg act gtg ctc gtg gcg ctc agt gcc atg ggc ttc acc tca gta gga      446
 Gly Thr Val Leu Val Ala Leu Ser Ala Met Gly Phe Thr Ser Val Gly
                  30                  35                  40

 atc gcc gca tcc tcc ata gca gcc aag atg atg tct aca gca gcc att      494
 Ile Ala Ala Ser Ser Ile Ala Ala Lys Met Met Ser Thr Ala Ala Ile
              45                  50                  55

 gcc aac ggg ggc gga gtt gct gct ggc agt ctg gtg gct att ctg cag      542
 Ala Asn Gly Gly Gly Val Ala Ala Gly Ser Leu Val Ala Ile Leu Gln
          60                  65                  70

 tca gtg ggg gca gct gga ctc tct gtg aca tct aaa gtt atc ggg ggc      590
 Ser Val Gly Ala Ala Gly Leu Ser Val Thr Ser Lys Val Ile Gly Gly
      75                  80                  85

 ttt gct ggg aca gct ctt ggg gcc tgg ctg ggt tca ccc cct tcc agc      638
 Phe Ala Gly Thr Ala Leu Gly Ala Trp Leu Gly Ser Pro Pro Ser Ser
  90                  95                 100                 105

 tga acac cacactgagg cagggagttg gctctcttgg tggagatgac tttcctgggc      695
 


 ctctggatga caatcttcca aaggacaagt ctcctactcc caaaactatt taaggaagca    755

 tgaaaaataa agatgctggt tatcttcaaa aaaaaaaa                            793




      <210> 118
      <211> 2692
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (18)..(2435)

      <400> 118
 tgtcagtgtc gggattc   atg gca gcc tca ggg gtg ccc aga gga tgc gac      50
                      Met Ala Ala Ser Gly Val Pro Arg Gly Cys Asp
                        1               5                  10

 atc ctc atc gtc tac agc ccg gat gcc gag gaa tgg tgc cag tac ctg       98
 Ile Leu Ile Val Tyr Ser Pro Asp Ala Glu Glu Trp Cys Gln Tyr Leu
              15                  20                  25

 cag acc ctg ttc ctg tcc agt cgg cag gtc cgc agc cag aag ata ctg      146
 Gln Thr Leu Phe Leu Ser Ser Arg Gln Val Arg Ser Gln Lys Ile Leu
          30                  35                  40

 act cac agg ctg ggc ccc gag gcc tcc ttc tcg gca gag gac cta agc      194
 Thr His Arg Leu Gly Pro Glu Ala Ser Phe Ser Ala Glu Asp Leu Ser
      45                  50                  55

 ctt ttc ctc agc acc cgc tgt gtc gtg gtg ctg ctg tcc gcg gag ctg      242
 Leu Phe Leu Ser Thr Arg Cys Val Val Val Leu Leu Ser Ala Glu Leu
  60                  65                  70                  75

 gtg cag cac ttc cac aag ccc gcc ttg ctg ccc ctg ctg cag aga gct      290
 Val Gln His Phe His Lys Pro Ala Leu Leu Pro Leu Leu Gln Arg Ala
                  80                  85                  90

 ttc cat cct ccg cac cgc gtg gtc agg ctg ctc tgc ggc gtg cgg gac      338
 Phe His Pro Pro His Arg Val Val Arg Leu Leu Cys Gly Val Arg Asp
              95                 100                 105

 agc gag gag ttc cta gac ttc ttt cca gat tgg gcc cat tgg cag gag      386
 Ser Glu Glu Phe Leu Asp Phe Phe Pro Asp Trp Ala His Trp Gln Glu
         110                 115                 120

 ctc acc tgt gac gat gag cca gag acc tac gtg gca gct gtg aaa aaa      434
 Leu Thr Cys Asp Asp Glu Pro Glu Thr Tyr Val Ala Ala Val Lys Lys
     125                 130                 135

 gcc att tcc gaa gat tct ggc tgt gac tca gtc act gac act gag cct      482
 Ala Ile Ser Glu Asp Ser Gly Cys Asp Ser Val Thr Asp Thr Glu Pro
 140                 145                 150                 155

 gag gac gag aag gtt gtt tcc tac tcg aag cag cag aac ctg ccg acg      530
 Glu Asp Glu Lys Val Val Ser Tyr Ser Lys Gln Gln Asn Leu Pro Thr
                 160                 165                 170

 gtg act tca cct ggg aac ctg atg gtg gtg cag ccg gac cgc att cgc      578
 Val Thr Ser Pro Gly Asn Leu Met Val Val Gln Pro Asp Arg Ile Arg
             175                 180                 185

 tgt ggg gca gaa acc act gtc tat gtt att gtg aga tgt aag ctg gat      626
 Cys Gly Ala Glu Thr Thr Val Tyr Val Ile Val Arg Cys Lys Leu Asp
         190                 195                 200

 gac agg gtg gcg aca gaa gca gag ttt tct cct gag gat tct ccc tct      674
 Asp Arg Val Ala Thr Glu Ala Glu Phe Ser Pro Glu Asp Ser Pro Ser
     205                 210                 215

 gta agg atg gaa gcc aag gtg gag aat gag tac acc att tca gtg aag      722
 Val Arg Met Glu Ala Lys Val Glu Asn Glu Tyr Thr Ile Ser Val Lys
 220                 225                 230                 235

 gct ccc aac ctt tca tct ggg aac gtt tct ctg aag ata tat tct gga      770
 Ala Pro Asn Leu Ser Ser Gly Asn Val Ser Leu Lys Ile Tyr Ser Gly
                 240                 245                 250

 gac tta gtg gtg tgt gaa acc gtt atc agc tat tat act gac atg gaa      818
 Asp Leu Val Val Cys Glu Thr Val Ile Ser Tyr Tyr Thr Asp Met Glu
             255                 260                 265

 gaa att ggg aat tta ttg tcc aat gcc gcg aat cct gtg gaa ttc atg      866
 Glu Ile Gly Asn Leu Leu Ser Asn Ala Ala Asn Pro Val Glu Phe Met
         270                 275                 280

 tgt cag gcc ttt aaa att gtg ccc tac aac aca gag acc ctt gat aaa      914
 Cys Gln Ala Phe Lys Ile Val Pro Tyr Asn Thr Glu Thr Leu Asp Lys
     285                 290                 295

 ctg cta acc gaa tcc ctg aag aac aat atc cct gca agc gga ctg cac      962
 Leu Leu Thr Glu Ser Leu Lys Asn Asn Ile Pro Ala Ser Gly Leu His
 300                 305                 310                 315

 ctc ttt gga atc aac cag ctg gaa gaa gaa gat atg atg aca aat cag     1010
 Leu Phe Gly Ile Asn Gln Leu Glu Glu Glu Asp Met Met Thr Asn Gln
                 320                 325                 330

 agg gat gaa gag ctg ccc acc ctg ttg cat ttt gct gcg aag tat gga     1058
 Arg Asp Glu Glu Leu Pro Thr Leu Leu His Phe Ala Ala Lys Tyr Gly
             335                 340                 345

 ctg aag aac ctc act gcc ttg ttg ctc acc tgc cca gga gcc ctg cag     1106
 Leu Lys Asn Leu Thr Ala Leu Leu Leu Thr Cys Pro Gly Ala Leu Gln
         350                 355                 360

 gcg tac agc gtg gcc aac aag cat ggc cac tac ccc aac acc atc gct     1154
 Ala Tyr Ser Val Ala Asn Lys His Gly His Tyr Pro Asn Thr Ile Ala
     365                 370                 375

 gag aaa cac ggc ttc agg gac ctg cgg cag ttc atc gac gag tat gtg     1202
 Glu Lys His Gly Phe Arg Asp Leu Arg Gln Phe Ile Asp Glu Tyr Val
 380                 385                 390                 395

 gaa acg gtg gac atg ctc aag agt cac att aaa gag gaa ctg atg cac     1250
 Glu Thr Val Asp Met Leu Lys Ser His Ile Lys Glu Glu Leu Met His
                 400                 405                 410

 ggg gag gag gct gat gct gtg tac gag tcc atg gcc cac ctt tcc aca     1298
 Gly Glu Glu Ala Asp Ala Val Tyr Glu Ser Met Ala His Leu Ser Thr
             415                 420                 425

 gac ctg ctt atg aaa tgc tcg ctc aac ccc ggc tgt gac gag gat ctc     1346
 Asp Leu Leu Met Lys Cys Ser Leu Asn Pro Gly Cys Asp Glu Asp Leu
         430                 435                 440

 tat gag tcc atg gct gcc ttt gtc cca gct gcc act gaa gac ctc tat     1394
 Tyr Glu Ser Met Ala Ala Phe Val Pro Ala Ala Thr Glu Asp Leu Tyr
     445                 450                 455

 gtt gaa atg ctt cag gcc agt aca tct aac cca atc cct gga gat ggt     1442
 Val Glu Met Leu Gln Ala Ser Thr Ser Asn Pro Ile Pro Gly Asp Gly
 460                 465                 470                 475

 ttc tct cgg gcc act aag gac tct atg atc cgc aag ttt tta gaa ggc     1490
 Phe Ser Arg Ala Thr Lys Asp Ser Met Ile Arg Lys Phe Leu Glu Gly
                 480                 485                 490

 aac agc atg gga atg acc aat ctg gag aga gat cag tgc cat ctt ggt     1538
 Asn Ser Met Gly Met Thr Asn Leu Glu Arg Asp Gln Cys His Leu Gly
             495                 500                 505

 cag gaa gaa gat gtt tat cac acg gtg gat gac gat gag gcc ttt tct     1586
 Gln Glu Glu Asp Val Tyr His Thr Val Asp Asp Asp Glu Ala Phe Ser
         510                 515                 520

 gtg gac ctg gcc agc agg ccc cct gtc cca gtg ccc aga cca gag acc     1634
 Val Asp Leu Ala Ser Arg Pro Pro Val Pro Val Pro Arg Pro Glu Thr
     525                 530                 535

 act gct cct ggt gct cac cag ctg cct gac aac gaa cca tac att ttt     1682
 Thr Ala Pro Gly Ala His Gln Leu Pro Asp Asn Glu Pro Tyr Ile Phe
 540                 545                 550                 555

 aaa gtt ttt gca gaa aaa agt caa gag cgg cct ggg aat ttc tac gtt     1730
 Lys Val Phe Ala Glu Lys Ser Gln Glu Arg Pro Gly Asn Phe Tyr Val
                 560                 565                 570

 tcc tca gag agc atc agg aaa ggg ccg ccc gtc aga cca tgg agg gac     1778
 Ser Ser Glu Ser Ile Arg Lys Gly Pro Pro Val Arg Pro Trp Arg Asp
             575                 580                 585

 agg ccc cag tcg agt ata tat gac cct ttt gcg gga atg aaa acg cca     1826
 Arg Pro Gln Ser Ser Ile Tyr Asp Pro Phe Ala Gly Met Lys Thr Pro
         590                 595                 600

 ggc cag cgg cag ctt atc acc ctc cag gag cag gtg aag ctg ggc att     1874
 Gly Gln Arg Gln Leu Ile Thr Leu Gln Glu Gln Val Lys Leu Gly Ile
     605                 610                 615

 gtc aac gtg gat gag gct gtg ctc cac ttc aaa gag tgg cag ctc aac     1922
 Val Asn Val Asp Glu Ala Val Leu His Phe Lys Glu Trp Gln Leu Asn
 620                 625                 630                 635

 cag aag aaa cga tcg gag tcc ttt cgt ttc cag cag gaa aat ctt aaa     1970
 Gln Lys Lys Arg Ser Glu Ser Phe Arg Phe Gln Gln Glu Asn Leu Lys
                 640                 645                 650

 cgg cta aga gac agc atc acc cga aga cag aga gag aag caa aaa tca     2018
 Arg Leu Arg Asp Ser Ile Thr Arg Arg Gln Arg Glu Lys Gln Lys Ser
             655                 660                 665

 gga aag cag aca gac ttg gag atc acg gtc cca att cgg cac tca cag     2066
 Gly Lys Gln Thr Asp Leu Glu Ile Thr Val Pro Ile Arg His Ser Gln
         670                 675                 680

 cac ctg cct gca aaa gtg gag ttt gga gtc tat gag agt ggc ccc agg     2114
 His Leu Pro Ala Lys Val Glu Phe Gly Val Tyr Glu Ser Gly Pro Arg
     685                 690                 695

 aaa agt gtc att ccc cct agg acg gag ctg aga cga gga gac tgg aaa     2162
 Lys Ser Val Ile Pro Pro Arg Thr Glu Leu Arg Arg Gly Asp Trp Lys
 700                 705                 710                 715

 aca gac agc acc tcc agc aca gca agt agc aca agt aac cgc tcc agc     2210
 Thr Asp Ser Thr Ser Ser Thr Ala Ser Ser Thr Ser Asn Arg Ser Ser
                 720                 725                 730

 acc cgg agc ctc ctc agt gtg agc agc ggg atg gaa ggg gac aac gag     2258
 Thr Arg Ser Leu Leu Ser Val Ser Ser Gly Met Glu Gly Asp Asn Glu
             735                 740                 745

 gat aat gaa gtc cct gag gtt acc aga agt cgc agt cca ggc ccc cca     2306
 Asp Asn Glu Val Pro Glu Val Thr Arg Ser Arg Ser Pro Gly Pro Pro
         750                 755                 760

 caa gtg gat ggg aca ccc acc atg tcc ctc gag aga ccc ccc agg gtg     2354
 Gln Val Asp Gly Thr Pro Thr Met Ser Leu Glu Arg Pro Pro Arg Val
     765                 770                 775

 cct ccg aga gct gcc tca cag agg cct ccg acc agg gag acc ttc cat     2402
 Pro Pro Arg Ala Ala Ser Gln Arg Pro Pro Thr Arg Glu Thr Phe His
 780                 785                 790                 795

 cct cct cca cct gtt cca ccc aga gga cgc tga ttccacct cctaaaacct     2453
 Pro Pro Pro Pro Val Pro Pro Arg Gly Arg 
                 800                 805

 gcctacttca ggactttaag actcacagtc ttcagcctgt taatgatgtc ttcatgttga   2513

 gttttatagc atgactgttg accttaagat ccattctcat tgctgataat gctgcagccc   2573

 tgctggtttg ggcttgcctc gaagatttta ttaaggcaca agcacagagt cagaaagcta   2633

 aataaaaaaa tgaaactttt ttgagtaata aaaatgaaaa gacgctgaaa aaaaaaaaa    2692




      <210> 119
      <211> 2017
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (943)..(1245)

      <400> 119
 agttctgggt tcagcccctt gagcttttgg tagaagaatc ttcatgaatc taataaataa     60

 ataaaacaaa taatgtaaga gctgaagacg gttgagctca tgtgagttta tataccaaag    120

 cattttcttc ctgggaagaa aaggtatctt ctatatattt tggtttccta aatttagatc    180

 tagaaataca ccattgtttt gttagagtgt attcttaggg tgtgtatgtg gggaggcaga    240

 ttgtaagcaa ccgattcaaa atttacctgg aacttcatag aataatgtca atgcttttta    300

 ggtagaaaaa tcattaccta caaatagggg atacattatg aacgtatttc aactaagcaa    360

 aagcatagtc aagtgccttc ataatgctaa attttagatg ttgcactgat gagatatttt    420

 ccctacaaat aaaagaccaa agtgtacaaa acctcaggac atgtggctga gttagaatta    480

 caatgcagct gtcatttttg catttcctgg ctttcatgaa tcattactag tgatcctctg    540

 tcatttaaat cagttgagaa catggattta tcttaatttt caccctttgt ttcccttttt    600

 catgataaca gtttgagata tgatgatgta aagtgtttct acttataatg gtttcagcct    660

 tgtcccttgg cagcctaaat cttctggcta attcactgat cagttaaata gtcgaggtta    720

 ttattattat aataattatt ttacatttat atagcacttt cctccaaggg gctcaaggca    780

 ttttacacac agtaaattac caaataggaa ttaatcctta tatcaccctg tggggtaggt    840

 acagtcacat aaatgaaatt ctacggaagt actgcctgtg tcacagtgct gagctctacc    900

 ccaaccccca gtgaacctgc cctgcctacc tgaagatgaa ga   atg ctg ttg gca     954
                                                  Met Leu Leu Ala
                                                    1

 tgg cag gga aaa gct gga aga aag atc ttg gga aaa tgg ccc gct gtc     1002
 Trp Gln Gly Lys Ala Gly Arg Lys Ile Leu Gly Lys Trp Pro Ala Val
   5                  10                  15                  20

 ctt act ttg gtg ctt tgg gct atc tgg aaa atg ata cta ttg aga gca     1050
 Leu Thr Leu Val Leu Trp Ala Ile Trp Lys Met Ile Leu Leu Arg Ala
                  25                  30                  35

 gct aag cat gtc ttg ata tgc aat tta cag ata agt ttc acc tat atg     1098
 Ala Lys His Val Leu Ile Cys Asn Leu Gln Ile Ser Phe Thr Tyr Met
              40                  45                  50

 gtt tta ttt aat cct gac aca aga caa ggt ggg atg tgg ttc tca aac     1146
 Val Leu Phe Asn Pro Asp Thr Arg Gln Gly Gly Met Trp Phe Ser Asn
          55                  60                  65

 ttc tgt gtg tat gga aat cac ttg gga gtg agt tta aaa ttc aga ttc     1194
 Phe Cys Val Tyr Gly Asn His Leu Gly Val Ser Leu Lys Phe Arg Phe
      70                  75                  80

 caa gaa ttt cta gct cat gga ggt tct aat aat tca aga aag ggc cat     1242
 Gln Glu Phe Leu Ala His Gly Gly Ser Asn Asn Ser Arg Lys Gly His
  85                  90                  95                 100

 tga catc tgaatttttg cctcagttga ttttgagtca cgtgatgttt acccatattt     1299
 


 tgtgaaactt gagctgatta aggaagaatt gttagtccca atctacatat cagaaaatga   1359

 tggctcaagc aggtaacatg tcacagtatt tggcagaggc tggactataa accaagtttt   1419

 gaaattccaa aactcatact cttttaatta cgctacagcg cttccaggaa agggaaaaca   1479

 gagaagccaa tacaacagga tttaaatgta aaggaaagga gagaacagtt agatatgcat   1539

 gtgagacact ttacagtaag gtaggctggc gtctactggc cctcttggaa cctcgagttg   1599

 atttgtgctg cctggatgga gaagaccatc atcttttggg cagggctgga ctgttccttg   1659

 gcagcttgtt ccttggtttc agaactacct tgttccctgt agccaacaag tcagtcaact   1719

 aactctaatc cagcaagtac ctgatggatt tgcaatgttt aatttttcat cctgcccaca   1779

 aaatgagtct cctccttaat agatgctgcc accaaaataa aagctggatt ttgccaggaa   1839

 accaagaaaa gttcttttaa taagcttcct gtttacgtga gtgggccctt tatgggatgg   1899

 gatgggtttt acgtttttta tttgaagcat tcttactcca tttctaaaag aatatattta   1959

 ttaaaaaaaa agatctttaa ttaagcgagt gcaagattat tccatttagt gagtgttt     2017




      <210> 120
      <211> 1541
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(1069)

      <400> 120
 ccgggtcgac ccacgcgtcc gaacattgac tgcctcaagg tctcaagcac cagtcttcac     60

 cgcggaaagc   atg ttg tgg ctg ttc caa tcg ctc ctg ttt gtc ttc tgc     109
              Met Leu Trp Leu Phe Gln Ser Leu Leu Phe Val Phe Cys
                1               5                  10

 ttt ggc cca ggg aat gta gtt tca caa agc agc tta acc cca ttg atg      157
 Phe Gly Pro Gly Asn Val Val Ser Gln Ser Ser Leu Thr Pro Leu Met
      15                  20                  25

 gtg aac ggg att ctg ggg gag tca gta act ctt ccc ctg gag ttt cct      205
 Val Asn Gly Ile Leu Gly Glu Ser Val Thr Leu Pro Leu Glu Phe Pro
  30                  35                  40                  45

 gca gga gag aag gtc aac ttc atc act tgg ctt ttc aat gaa aca tct      253
 Ala Gly Glu Lys Val Asn Phe Ile Thr Trp Leu Phe Asn Glu Thr Ser
                  50                  55                  60

 ctt gcc ttc ata gta ccc cat gaa acc aaa agt cca gaa atc cac gtg      301
 Leu Ala Phe Ile Val Pro His Glu Thr Lys Ser Pro Glu Ile His Val
              65                  70                  75

 act aat ccg aaa cag gga aag cga ctg aac ttc acc cag tcc tac tcc      349
 Thr Asn Pro Lys Gln Gly Lys Arg Leu Asn Phe Thr Gln Ser Tyr Ser
          80                  85                  90

 ctg caa ctc agc aac ctg aag atg gaa gac aca ggc tct tac aga gcc      397
 Leu Gln Leu Ser Asn Leu Lys Met Glu Asp Thr Gly Ser Tyr Arg Ala
      95                 100                 105

 cag ata tcc aca aag acc tct gca aag ctg tcc agt tac act ctg agg      445
 Gln Ile Ser Thr Lys Thr Ser Ala Lys Leu Ser Ser Tyr Thr Leu Arg
 110                 115                 120                 125

 ata tta aga caa ctg agg aac ata caa gtt acc aat cac agt cag cta      493
 Ile Leu Arg Gln Leu Arg Asn Ile Gln Val Thr Asn His Ser Gln Leu
                 130                 135                 140

 ttt cag aat atg acc tgt gag ctc cat ctg act tgc tct gtg gag gat      541
 Phe Gln Asn Met Thr Cys Glu Leu His Leu Thr Cys Ser Val Glu Asp
             145                 150                 155

 gca gat gac aat gtc tca ttc aga tgg gag gcc ttg gga aac aca ctt      589
 Ala Asp Asp Asn Val Ser Phe Arg Trp Glu Ala Leu Gly Asn Thr Leu
         160                 165                 170

 tca agt cag cca aac ctc act gtc tcc tgg gac ccc agg att tcc agt      637
 Ser Ser Gln Pro Asn Leu Thr Val Ser Trp Asp Pro Arg Ile Ser Ser
     175                 180                 185

 gaa cag gac tac acc tgc ata gca gag aat gct gtc agt aat tta tcc      685
 Glu Gln Asp Tyr Thr Cys Ile Ala Glu Asn Ala Val Ser Asn Leu Ser
 190                 195                 200                 205

 ttc tct gtc tct gcc cag aag ctt tgc gaa gat gtt aaa att caa tat      733
 Phe Ser Val Ser Ala Gln Lys Leu Cys Glu Asp Val Lys Ile Gln Tyr
                 210                 215                 220

 aca gat acc aaa atg att ctg ttt atg gtt tct ggg ata tgc ata gtc      781
 Thr Asp Thr Lys Met Ile Leu Phe Met Val Ser Gly Ile Cys Ile Val
             225                 230                 235

 ttc ggt ttc atc ata ctg ctg tta ctt gtt ttg agg aaa aga aga gat      829
 Phe Gly Phe Ile Ile Leu Leu Leu Leu Val Leu Arg Lys Arg Arg Asp
         240                 245                 250

 tcc cta tct ttg tct act cag cga aca cag ggc ccc gca gag tcc gca      877
 Ser Leu Ser Leu Ser Thr Gln Arg Thr Gln Gly Pro Ala Glu Ser Ala
     255                 260                 265

 agg aac cta gag tat gtt tca gtg tct cca acg aac aac act gtg tat      925
 Arg Asn Leu Glu Tyr Val Ser Val Ser Pro Thr Asn Asn Thr Val Tyr
 270                 275                 280                 285

 gct tca gtc act cat tca aac agg gaa aca gaa atc tgg aca cct aga      973
 Ala Ser Val Thr His Ser Asn Arg Glu Thr Glu Ile Trp Thr Pro Arg
                 290                 295                 300

 gaa aat gat act atc aca att tac tcc aca att aat cat tcc aaa gag     1021
 Glu Asn Asp Thr Ile Thr Ile Tyr Ser Thr Ile Asn His Ser Lys Glu
             305                 310                 315

 agt aaa ccc act ttt tcc agg gca act gcc ctt gac aat gtc gtg taa     1069
 Ser Lys Pro Thr Phe Ser Arg Ala Thr Ala Leu Asp Asn Val Val 
         320                 325                 330

 gttgctgaaa ggcctcagag gaattcggga atgacacgtc ttctgatccc atgagacaga   1129

 acaaagaaca ggaagcttgg ttcctgttgt tcctggcaac agaatttgaa tatctaggat   1189

 aggatgatca cctccagtcc ttcggactta aacctgccta cctgagtcaa acacctaagg   1249

 ataacatcat ttccagcatg tggttcaaat aatattttcc aatccacttc aggccaaaac   1309

 atgctaaaga taacacacca gcacattgac tctctctttg ataactaagc aaatggaatt   1369

 atggttgaca gagagtttat gatccagaag acaaccactt ctctcctttt agaaagcagc   1429

 aggattgact tattgagaaa taatgcagtg tgttggttac atgtgtagtc tctggagttg   1489

 gatgggccca tcctgataca agttgagcat tccttgtctg aaatgcttgg ag           1541




      <210> 121
      <211> 854
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (441)..(614)

      <400> 121
 gcttgagaaa agtgaagagg tgaaaaaagc tgcatatgca aaaggagatc agcagcttcg     60

 tgtttaaggt tggggtaggg aagtggggaa aactggggac tggactggcc tacccatgca    120

 tctttgggat gaattaatca tttgcttgtg gactgatttt tgtttttcac ctattgaggt    180

 ataatttgca tatgataaaa taagcccatt tctgtgtgta atttaatgac tgttagtaaa    240

 tttgccaagt tgtacaccca tagtgcctcc tcttcttcct aacaccatct catttctctg    300

 tttttggcac cccagtgttt gattgcatcg aggtctatgc ccctggcttc aaggactctg    360

 tggttggcag agacatcctc acaccaccag atttggagag aatcttcggg cttcctggag    420

 ggaacatatt ccactgcgcc    atg tcc ctg gac cag ctc tac ttc gcc cgc     470
                          Met Ser Leu Asp Gln Leu Tyr Phe Ala Arg
                            1               5                  10

 ccc gtg ccc ctg cat tct ggc tac cgc tgc cct ctc cag ggc ctg tat      518
 Pro Val Pro Leu His Ser Gly Tyr Arg Cys Pro Leu Gln Gly Leu Tyr
                  15                  20                  25

 ctc tgt gga agt ggg gct cat cct gga gga ggt gtg atg gga gct gct      566
 Leu Cys Gly Ser Gly Ala His Pro Gly Gly Gly Val Met Gly Ala Ala
              30                  35                  40

 ggg cga aat gca gca cat gtg gcc ttt agg gac ctc aag agc atg tga      614
 Gly Arg Asn Ala Ala His Val Ala Phe Arg Asp Leu Lys Ser Met 
          45                  50                  55

 ccctgaacca gctctgaccc aggaagaaga ctccacccct gaattccaag tgctccattg    674

 gatcagcttc ccaggaagtt cagcttcggg ttagtacata aggccaccac aatgctcaag    734

 aaattatttt agaaaaaacg tacgagttac atttagtgca agttgacctt atgcccatgc    794

 ctccatacat ggactggttc tgttttatta aaactaatat ttcatacaga aaaaaaaaaa    854




      <210> 122
      <211> 778
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (144)..(482)

      <220>
      <221> misc_feature
      <222> (1)...(778)
      <223> n = a,t,c or g

      <400> 122
 ccctctagat gcatgctcga gcggccgcca gtgtgatgga tatctgcaga attcgccctt     60

 actcactata gggctcgagc ggccgcccgg gcaggtcgtc agtctagaag gataagagaa    120

 agaaagttaa gcaactacag gaa    atg gct ttg gga gtt cca ata tca gtc     170
                              Met Ala Leu Gly Val Pro Ile Ser Val
                                1               5

 tat ctt tta ttc aac gca atg aca gca ctg acc gaa gag gca gcc gtg      218
 Tyr Leu Leu Phe Asn Ala Met Thr Ala Leu Thr Glu Glu Ala Ala Val
  10                  15                  20                  25

 act gta aca cct cca atc aca gcc cag caa ggt aac tgg aca gtt aac      266
 Thr Val Thr Pro Pro Ile Thr Ala Gln Gln Gly Asn Trp Thr Val Asn
                  30                  35                  40

 aaa aca gaa gct gac aac ata gaa gga ccc ata gcc ttg aag ttc tca      314
 Lys Thr Glu Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser
              45                  50                  55

 cac ctt tgc ctg gaa gat cat aac agt tac tgc atc aac ggt gct tgt      362
 His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys
          60                  65                  70

 gca ttc cac cat gag cta gag aaa gcc atc tgc agg tgt ttt act ggt      410
 Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys Phe Thr Gly
      75                  80                  85

 tat act gga gaa agg tgt cta aaa ttg aaa tcg cct tac aat gtc tgt      458
 Tyr Thr Gly Glu Arg Cys Leu Lys Leu Lys Ser Pro Tyr Asn Val Cys
  90                  95                 100                 105

 tct gga gaa aga cga cca ctg tga ggcctttgtg aagaattttc atcaaggcat     512
 Ser Gly Glu Arg Arg Pro Leu 
                 110

 ctgtagagat cagtgagccc aaaattaaag ttttcagatg aaacaacaaa acttgtcaag    572

 ctgactagac tcgaaaataa tgaaagttgg gatcacaatg aaatgagaag ataaaattca    632

 gcgttggcct ttagactttg ccatccttaa ggagtgatgg aagccaagtg aacaagcctc    692

 agtgacacaa gtcaaattca tagtttcact ctgggttttt tgttgttgtg tggntattat    752

 tctcactaca gaaagactga gtttca                                         778




      <210> 123
      <211> 402
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(402)

      <400> 123
  atg gct ttg gga gtt cca ata tca gtc tat ctt tta ttc aac gca atg      48
  Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met
    1               5                  10                  15

 aca gca ctg acc gaa gag gca gcc gtg act gta aca cct cca atc aca       96
 Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr
              20                  25                  30

 gcc cag caa ggt aac tgg aca gtt aac aaa aca gaa gct gac aac ata      144
 Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile
          35                  40                  45

 gaa gga ccc ata gcc ttg aag ttc tca cac ctt tgc ctg gaa gat cat      192
 Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His
      50                  55                  60

 aac agt tac tgc atc aac ggt gct tgt gca ttc cac cat gag cta gag      240
 Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu
  65                  70                  75                  80

 aaa gcc atc tgc agg tgt ttt act ggt tat act gga gaa agg tgt cta      288
 Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Leu
                  85                  90                  95

 aaa ttg aaa tcg cct tac aat gtc tgt tct gga gaa aga cga cca ctt      336
 Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu
             100                 105                 110

 tat cag tgg aat tac ctg gtg acc att cat tcg gac cga act act gga      384
 Tyr Gln Trp Asn Tyr Leu Val Thr Ile His Ser Asp Arg Thr Thr Gly
         115                 120                 125

 atg tct cct act gaa taa                                              402
 Met Ser Pro Thr Glu 
     130





      <210> 124
      <211> 1475
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (336)..(674)

      <400> 124
 tatcgccccc caagtgtgat gggattcgcc cctaagcagt ggtaccatcg aggagtctgc     60

 gggtaccaac gtgaatatgc ccacaggtaa caggaaacca gtgtttcaaa agaaaacttg    120

 atcacattgc tagataatac aggtatccta accaagtgcg tgagcgccca gaggctttct    180

 gctgctgcca gaagtacata tttttttgat tggtaagaac tgccagatga cgcttcatga    240

 aatataaatg caacaaagac tcagagagct caataaaaac cttccacccg tcagtctaga    300

 aggataagag aaagaaagtt aagcaactac aggaa   atg gct ttg gga gtt cca     353
                                          Met Ala Leu Gly Val Pro
                                            1               5

 ata tca gtc tat ctt tta ttc aac gca atg aca gca ctg acc gaa gag      401
 Ile Ser Val Tyr Leu Leu Phe Asn Ala Met Thr Ala Leu Thr Glu Glu
              10                  15                  20

 gca gcc gtg act gta aca cct cca atc aca gcc cag caa ggt aac tgg      449
 Ala Ala Val Thr Val Thr Pro Pro Ile Thr Ala Gln Gln Gly Asn Trp
          25                  30                  35

 aca gtt aac aaa aca gaa gct gac aac ata gaa gga ccc ata gcc ttg      497
 Thr Val Asn Lys Thr Glu Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu
      40                  45                  50

 aag ttc tca cac ctt tgc ctg gaa gat cat aac agt tac tgc atc aac      545
 Lys Phe Ser His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn
  55                  60                  65                  70

 ggt gct tgt gca ttc cac cat gag cta gag aaa gcc atc tgc agg tgt      593
 Gly Ala Cys Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys
                  75                  80                  85

 ttt act ggt tat act gga gaa agg tgt cta aaa ttg aaa tcg cct tac      641
 Phe Thr Gly Tyr Thr Gly Glu Arg Cys Leu Lys Leu Lys Ser Pro Tyr
              90                  95                 100

 aat gtc tgt tct gga gaa aga cga cca ctg tga ggcctttg tgaagaattt      692
 Asn Val Cys Ser Gly Glu Arg Arg Pro Leu 
         105                 110

 tcatcaaggc atctgtagag atcagtgagc ccaaaattaa agttttcaga tgaaacaaca    752

 aaacttgtca agctgactag actcgaaaat aatgaaagtt gggatcacaa tgaaatgaga    812

 agataaaatt cagcgttggc ctttagactt tgccatcctt aaggagtgat ggaagccaag    872

 tgaacaagcc tcagtgacac aagtcaaatt catagtttca ctctgggttt tttgttgttg    932

 tgtggttatt attctcacta cagaaagact gagtttcatg ctcctggcta tgtcagatgt    992

 gaattttcat gggaataata atcaaccttg cagcaagcca aagcaatgcc tcgcttgggt   1052

 tcttcatgtt cttactaccc agcgtttttt accacctaga tgggcctctc taagtctatt   1112

 tgctcaatga accttatccc aaacttgttg ttttcatggt gtctgaaaga atgtgatgtc   1172

 agcttttaga atgaaatcag tgttaaggta cctccagtga accaaacatg tgtcttaaat   1232

 ctaagccact gaaaacagaa gggaatgtcc aaggcaaata caaatcatac acagcttgta   1292

 acaacataca gcctttctat gtgaaataat ggaataaact aaagagtttc tgaagactga   1352

 agctatctgg atatcaagtc tggagtaggc aaagcatttc catttctaca tggattataa   1412

 aactttgtgt tggactcatt ggtccctaat gcttttgttc atcacgtgga cgcgtccgcg   1472

 aat                                                                 1475




      <210> 125
      <211> 844
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(582)

      <400> 125
  atg gcg cct cct ctg cga ccc ctc gcc cgg ctg cga ccg ccg ggg atg      48
  Met Ala Pro Pro Leu Arg Pro Leu Ala Arg Leu Arg Pro Pro Gly Met
    1               5                  10                  15

 ctg ctc cgc gcg ctc ctg ctc ctg ctg ctg ctc agt cct ttg cca ggg       96
 Leu Leu Arg Ala Leu Leu Leu Leu Leu Leu Leu Ser Pro Leu Pro Gly
              20                  25                  30

 ctg cga gag gga ata ggt gaa ctc ata acc cca atc ggc acc agc ttg      144
 Leu Arg Glu Gly Ile Gly Glu Leu Ile Thr Pro Ile Gly Thr Ser Leu
          35                  40                  45

 ccg gat ctg gat cca gcc agg agg aga tgg gag ggt gga att ggc agg      192
 Pro Asp Leu Asp Pro Ala Arg Arg Arg Trp Glu Gly Gly Ile Gly Arg
      50                  55                  60

 gtt gga agt gaa gtg gcc gat ttg tgc ccc gga aag gag ggg gga aaa      240
 Val Gly Ser Glu Val Ala Asp Leu Cys Pro Gly Lys Glu Gly Gly Lys
  65                  70                  75                  80

 gtc ccc gaa gct gaa aag gaa gga gtg tgg tgc ttt agc gaa ctg tct      288
 Val Pro Glu Ala Glu Lys Glu Gly Val Trp Cys Phe Ser Glu Leu Ser
                  85                  90                  95

 ttt gta aaa gaa cca cag gat gta act gtc aca aga aag gac cca gtc      336
 Phe Val Lys Glu Pro Gln Asp Val Thr Val Thr Arg Lys Asp Pro Val
             100                 105                 110

 gtt tta gat tgc cag gct cac gga gaa gtt cct att aag gtc aca tgg      384
 Val Leu Asp Cys Gln Ala His Gly Glu Val Pro Ile Lys Val Thr Trp
         115                 120                 125

 ttg aaa aat gga gca aaa atg tct gaa aat aaa cgg atc gag gtt ctt      432
 Leu Lys Asn Gly Ala Lys Met Ser Glu Asn Lys Arg Ile Glu Val Leu
     130                 135                 140

 tct aac ggc tct tta tac atc agt gag gtg gaa ggc agg cga gga gag      480
 Ser Asn Gly Ser Leu Tyr Ile Ser Glu Val Glu Gly Arg Arg Gly Glu
 145                 150                 155                 160

 cag tcc gat gaa gga ttt tat cag tgc ttg gca atg aac aaa tat gga      528
 Gln Ser Asp Glu Gly Phe Tyr Gln Cys Leu Ala Met Asn Lys Tyr Gly
                 165                 170                 175

 gcc att ctt agt caa aaa gct cat ctt gcc tta tca agg ata ggg agt      576
 Ala Ile Leu Ser Gln Lys Ala His Leu Ala Leu Ser Arg Ile Gly Ser
             180                 185                 190

 aca tag tggaggtggc cagataggcc atgagaagat gaagcatttg tcatgaccac       632
 Thr 


 acattgtttc caggacctcc tgagaagcct gatagaatcc tagggcttcc agaaacactt    692

 ttggaaaaac acagagcttt ctaacttcat aaataaaatg tgaatggtgt gtgataggtg    752

 taacaaacaa aatgtcagaa ctggcttttt aaatatcttt agatttttgc atctctatag    812

 aaattatcac taataataaa tatgtacatg cg                                  844




      <210> 126
      <211> 871
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (274)..(660)

      <400> 126
 aggctctcca ggcactgtcc cctaagtgac agctgttact gcctgggaga gctcaagtgc     60

 aaagactatc ctgttctccc ataaagagga ggaaaaggaa gatacagaaa tcggtgctgc    120

 tcccaacagc agatcaaggc agtcgtcagg aactcaggat ccggggggtc ttcacggctt    180

 ctctgcccag gggccagaac cgaggaggcc aggagggctg ctggggctaa ggggtctaag    240

 gacctcgttg cacacgctac caggagcagg ggc atg gag cac agt gag ggg gct     294
                                      Met Glu His Ser Glu Gly Ala
                                        1               5

 ccc gga gac cca gcc ggt act gtg gta ccc cag gag ctg ctg gaa gag      342
 Pro Gly Asp Pro Ala Gly Thr Val Val Pro Gln Glu Leu Leu Glu Glu
          10                  15                  20

 atg ctt tgg ttt ttt cgt gtg gaa gat gca tct ccc tgg aat cat tcc      390
 Met Leu Trp Phe Phe Arg Val Glu Asp Ala Ser Pro Trp Asn His Ser
      25                  30                  35

 atc ctt gcc ctg gca gct gtg gtg gtc att ata agc atg gtc ctc ctg      438
 Ile Leu Ala Leu Ala Ala Val Val Val Ile Ile Ser Met Val Leu Leu
  40                  45                  50                  55

 gga aga agc atc cag gca agc aga aaa gaa aag atg cag cca cca gaa      486
 Gly Arg Ser Ile Gln Ala Ser Arg Lys Glu Lys Met Gln Pro Pro Glu
                  60                  65                  70

 aaa gaa act cca gaa gtc ctg cat ttg gat gag gcc aag gat cac aac      534
 Lys Glu Thr Pro Glu Val Leu His Leu Asp Glu Ala Lys Asp His Asn
              75                  80                  85

 agc cta aac aac cta aga gaa act ttg ctc tca gaa aag cca aac ttg      582
 Ser Leu Asn Asn Leu Arg Glu Thr Leu Leu Ser Glu Lys Pro Asn Leu
          90                  95                 100

 gcc cag gtg gaa ctt gag tta aaa gag aga gat gtg ctg tca gtt ttc      630
 Ala Gln Val Glu Leu Glu Leu Lys Glu Arg Asp Val Leu Ser Val Phe
     105                 110                 115

 ctt ccg gat gta cca gaa act gag agc tag t gagggttcag agaagcccca      681
 Leu Pro Asp Val Pro Glu Thr Glu Ser 
 120                 125

 tcctaagcca gacacatgat gtgggctcag ctcagtggcc tgaaacctct caggttttag    741

 agtctctccc aagaagccgc ttttttcttt ttctttcttt cttttttttt ttcttagcag    801

 atacaatgaa tgaactgcaa gcaaactaaa attctgttat taaaaaaaat cttttattaa    861

 aaaaaaaaaa                                                           871




      <210> 127
      <211> 639
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(639)

      <400> 127
  atg gca gca gcc gcc atc cca gct ttg ctt ctg tgc ctc ccg ctt ctg      48
  Met Ala Ala Ala Ala Ile Pro Ala Leu Leu Leu Cys Leu Pro Leu Leu
    1               5                  10                  15

 ttc ctg ctg ttc ggc tgg tcc cgg gct agg cga gac gac cct cac tct       96
 Phe Leu Leu Phe Gly Trp Ser Arg Ala Arg Arg Asp Asp Pro His Ser
              20                  25                  30

 ctt tgc tat gac atc acc gtc atc cct aag ttc aga cct gga cca cgg      144
 Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg
          35                  40                  45

 tgg tgt gcg gtt caa ggc cag gtg gat gaa aag act ttt ctt cac tat      192
 Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr
      50                  55                  60

 gac tgt ggc aac aag aca gtc aca ccc gtc agt ccc ctg ggg aag aaa      240
 Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys
  65                  70                  75                  80

 cta aat gtc aca acg gcc tgg aaa gca cag aac cca gta ctg aga gag      288
 Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu
                  85                  90                  95

 gtg gtg gac ata ctt aca gag caa ctg cgt gac att cag ctg gag aat      336
 Val Val Asp Ile Leu Thr Glu Gln Leu Arg Asp Ile Gln Leu Glu Asn
             100                 105                 110

 tac aca ccc aag gaa ccc ctc acc ctg cag gca agg atg tct tgt gag      384
 Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu
         115                 120                 125

 cag aaa gct gaa gga cac agc agt gga tct tgg cag ttc agt atc gat      432
 Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln Phe Ser Ile Asp
     130                 135                 140

 gga cag atc ttc cta ctc ttt gac tca gag aag aga atg tgg aca acg      480
 Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg Met Trp Thr Thr
 145                 150                 155                 160

 gtt cat cct gga gcc aga aag atg aaa gaa aag tgg gag aat gac aag      528
 Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys
                 165                 170                 175

 gat gtg gcc atg tcc ttc cat tac atc tca atg gga gac tgc ata gga      576
 Asp Val Ala Met Ser Phe His Tyr Ile Ser Met Gly Asp Cys Ile Gly
             180                 185                 190

 tgg ctt gag gac ttc ttg atg ggc atg gac agc acc ctg gag cca agt      624
 Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser
         195                 200                 205

 gca gga gac aca tag                                                  639
 Ala Gly Asp Thr 
     210





      <210> 128
      <211> 2464
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(1743)

      <220>
      <221> misc_feature
      <222> (1)...(2464)
      <223> n = a,t,c or g

      <400> 128
 gtaagtgcgg tggaattcgt gctccatggg aaagatttcc aagtagattg caaagcttcc     60

 ggctccccag tgccttagat atcttggagt ttgcttgatg gaacc    atg atc aac     114
                                                      Met Ile Asn
                                                        1

 aat gca atg caa gcc gat gac agt ggc cac agg act agg aga tat acc      162
 Asn Ala Met Gln Ala Asp Asp Ser Gly His Arg Thr Arg Arg Tyr Thr
       5                  10                  15

 ctt ttc aac aat gga act tta tac ttc aac aaa gtt ggg gta gcg gag      210
 Leu Phe Asn Asn Gly Thr Leu Tyr Phe Asn Lys Val Gly Val Ala Glu
  20                  25                  30                  35

 gaa gga gat tat act tgc tat gcc cag aac acc cta ggg aaa gat gaa      258
 Glu Gly Asp Tyr Thr Cys Tyr Ala Gln Asn Thr Leu Gly Lys Asp Glu
                  40                  45                  50

 atg aag gtc cac tta aca gtt ata aca gct gct ccc cgg ata agg cag      306
 Met Lys Val His Leu Thr Val Ile Thr Ala Ala Pro Arg Ile Arg Gln
              55                  60                  65

 agt aac aaa acc aac aag aga atc aaa gct gga gac aca gct gtc ctt      354
 Ser Asn Lys Thr Asn Lys Arg Ile Lys Ala Gly Asp Thr Ala Val Leu
          70                  75                  80

 gac tgt gag gtc act ggg gat ccc aaa cca aaa ata ttt tgg ttg ctg      402
 Asp Cys Glu Val Thr Gly Asp Pro Lys Pro Lys Ile Phe Trp Leu Leu
      85                  90                  95

 cct tcc aat gac atg att tcc ttc tcc att gat agg tac aca ttt cat      450
 Pro Ser Asn Asp Met Ile Ser Phe Ser Ile Asp Arg Tyr Thr Phe His
 100                 105                 110                 115

 gcc aat ggg tct ttg acc atc aac aaa gtg aaa ctg ctc gat tct gga      498
 Ala Asn Gly Ser Leu Thr Ile Asn Lys Val Lys Leu Leu Asp Ser Gly
                 120                 125                 130

 gag tac gta tgt gta gcc cga aat ccc agt ggg gat gac acc aaa atg      546
 Glu Tyr Val Cys Val Ala Arg Asn Pro Ser Gly Asp Asp Thr Lys Met
             135                 140                 145

 tac aaa ctg gat gtg gtc tct aaa cct cca tta atc aat ggt ctg tat      594
 Tyr Lys Leu Asp Val Val Ser Lys Pro Pro Leu Ile Asn Gly Leu Tyr
         150                 155                 160

 aca aat aga act gtt att aaa gcc aca gct gtg aga cat tcc aaa aaa      642
 Thr Asn Arg Thr Val Ile Lys Ala Thr Ala Val Arg His Ser Lys Lys
     165                 170                 175

 cac ttt gac tgc aga gct gaa ggg aca cca tct cct gaa gtc atg tgg      690
 His Phe Asp Cys Arg Ala Glu Gly Thr Pro Ser Pro Glu Val Met Trp
 180                 185                 190                 195

 atc atg cca gac aat att ttc ctc aca gcc cca tac tat gga agc aga      738
 Ile Met Pro Asp Asn Ile Phe Leu Thr Ala Pro Tyr Tyr Gly Ser Arg
                 200                 205                 210

 atc aca gtc cat aaa aat gga acc ttg gaa att agg aat gtg agg ctt      786
 Ile Thr Val His Lys Asn Gly Thr Leu Glu Ile Arg Asn Val Arg Leu
             215                 220                 225

 tca gat tca gcc gac ttt atc tgt gtg gcc cga aat gaa ggt gga gag      834
 Ser Asp Ser Ala Asp Phe Ile Cys Val Ala Arg Asn Glu Gly Gly Glu
         230                 235                 240

 agc gtg ttg gta gta cag tta gaa gta ctg gaa atg ctg aga aga ccg      882
 Ser Val Leu Val Val Gln Leu Glu Val Leu Glu Met Leu Arg Arg Pro
     245                 250                 255

 aca ttt aga aat cca ttt aat gaa aaa ata gtt gcc cag ctg gga aag      930
 Thr Phe Arg Asn Pro Phe Asn Glu Lys Ile Val Ala Gln Leu Gly Lys
 260                 265                 270                 275

 tcc aca gca ttg aat tgc tct gtt gat ggt aac cca cca cct gaa ata      978
 Ser Thr Ala Leu Asn Cys Ser Val Asp Gly Asn Pro Pro Pro Glu Ile
                 280                 285                 290

 atc tgg att tta cca aat ggc aca cga ttt tcc aat gga cca caa agt     1026
 Ile Trp Ile Leu Pro Asn Gly Thr Arg Phe Ser Asn Gly Pro Gln Ser
             295                 300                 305

 tat cag tat ctg ata gca agc aat ggt tct ttt atc att tct aaa aca     1074
 Tyr Gln Tyr Leu Ile Ala Ser Asn Gly Ser Phe Ile Ile Ser Lys Thr
         310                 315                 320

 act cgg gag gat gca gga aaa tat cgc tgt gca gct agg aat aaa gtt     1122
 Thr Arg Glu Asp Ala Gly Lys Tyr Arg Cys Ala Ala Arg Asn Lys Val
     325                 330                 335

 ggc tat att gag aaa tta gtc ata tta gaa att ggc cag aag cca gtt     1170
 Gly Tyr Ile Glu Lys Leu Val Ile Leu Glu Ile Gly Gln Lys Pro Val
 340                 345                 350                 355

 att ctt acc tat gca cca ggg aca gta aaa ggc atc agt gga gaa tct     1218
 Ile Leu Thr Tyr Ala Pro Gly Thr Val Lys Gly Ile Ser Gly Glu Ser
                 360                 365                 370

 cta tca ctg cat tgt gtg tct gat gga atc cct aag cca aat atc aaa     1266
 Leu Ser Leu His Cys Val Ser Asp Gly Ile Pro Lys Pro Asn Ile Lys
             375                 380                 385

 tgg act atg cca agt ggt tat gta gta gac agg cct caa att aat ggg     1314
 Trp Thr Met Pro Ser Gly Tyr Val Val Asp Arg Pro Gln Ile Asn Gly
         390                 395                 400

 aaa tac ata ttg cat gac aat ggc acc tta gtc att aaa gaa gca aca     1362
 Lys Tyr Ile Leu His Asp Asn Gly Thr Leu Val Ile Lys Glu Ala Thr
     405                 410                 415

 gct tat gac aga gga aac tat atc tgt aag gct caa aat agt gtt ggt     1410
 Ala Tyr Asp Arg Gly Asn Tyr Ile Cys Lys Ala Gln Asn Ser Val Gly
 420                 425                 430                 435

 cat aca ctg att act gtt cca gta atg att gta gcc tac cct ccc cga     1458
 His Thr Leu Ile Thr Val Pro Val Met Ile Val Ala Tyr Pro Pro Arg
                 440                 445                 450

 att aca aat cgt cca ccc agg agt att gtc acc agg aca ggg gca gcc     1506
 Ile Thr Asn Arg Pro Pro Arg Ser Ile Val Thr Arg Thr Gly Ala Ala
             455                 460                 465

 ttt cag ctc cac tgt gtg gcc ttg gga gtt ccc aag cca gaa atc acg     1554
 Phe Gln Leu His Cys Val Ala Leu Gly Val Pro Lys Pro Glu Ile Thr
         470                 475                 480

 tgg gag atg cct gac cac tcc ctt ctc tca acg gca agt aaa gag agg     1602
 Trp Glu Met Pro Asp His Ser Leu Leu Ser Thr Ala Ser Lys Glu Arg
     485                 490                 495

 aca cat gga agt gag cag ctt cac tta caa ggt acc cta gtc att cag     1650
 Thr His Gly Ser Glu Gln Leu His Leu Gln Gly Thr Leu Val Ile Gln
 500                 505                 510                 515

 aat ccc caa acc tcc gat tct ggg ata tac aaa tgc aca gca aag aac     1698
 Asn Pro Gln Thr Ser Asp Ser Gly Ile Tyr Lys Cys Thr Ala Lys Asn
                 520                 525                 530

 cca ctt ggt agt gat tat gca gca acg tat att caa gta atc tga cat     1746
 Pro Leu Gly Ser Asp Tyr Ala Ala Thr Tyr Ile Gln Val Ile 
             535                 540                 545

 gaaataataa agtcaacaac atctgggcag aatttatttt ttggaagaag tttaatcaaa   1806

 ggcagccata ggcatgtaaa tgaatttgaa tacatttaca gtattaaatt tacaatgaac   1866

 atgcaaaata aaaggacttg taaataaatg cattatgaac tgatgatact gatttattta   1926

 atggatctca aaacaaactt ttaacttaag gcacttttat tttgccaaca aataacaata   1986

 aacaaacatt gaaacggttc actataaaat aacaaatggc taatgtacct gaatttttca   2046

 gtaaaaaaat gaacttctaa taccagttgc ctagtgtcca cctcctatca atgttacaag   2106

 catggcactc agaacagaga caatggaaaa tattaaatct gcaatcttta tgatgtaaat   2166

 ttaccatcct gatgtataaa tattttgtgg tttataaatt tttttgctaa aacctaaaaa   2226

 aaaaaaaaaa aaaaaaaaaa nggggggggc ctttttaaag gatcaaattt tacttcccgg   2286

 tgtttggaaa aaaaaaattt ttttttgggg gccccaaaat taatttccgg ggccgggttt   2346

 taaaaacgtg gggatgggaa aaaccttggg tttcccaaat taaaacgctt tggaaaaaat   2406

 cccctttttc acattggggg aataaccaaa aaaaggccgg gnnnnnattt nattatac     2464




      <210> 129
      <211> 7996
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(7287)

      <400> 129
  atg aaa gac acc aag tgt gcg gga cat aga agg aac agc gta tgc cag      48
  Met Lys Asp Thr Lys Cys Ala Gly His Arg Arg Asn Ser Val Cys Gln
    1               5                  10                  15

 agc caa tgg ggc atg gca ggg ttg agg aat gga aag gat ttc cat ggg       96
 Ser Gln Trp Gly Met Ala Gly Leu Arg Asn Gly Lys Asp Phe His Gly
              20                  25                  30

 gct gga acc gag gga atg ggg gtg ata tgg tca gat gta ata aaa tgc      144
 Ala Gly Thr Glu Gly Met Gly Val Ile Trp Ser Asp Val Ile Lys Cys
          35                  40                  45

 aaa aaa gat aga agt ccc tct agt gct cag cag tgt cca ctt tgc atg      192
 Lys Lys Asp Arg Ser Pro Ser Ser Ala Gln Gln Cys Pro Leu Cys Met
      50                  55                  60

 aac cct agg act tct aaa ggc aag ccg tta gct atg gtc tca gct gca      240
 Asn Pro Arg Thr Ser Lys Gly Lys Pro Leu Ala Met Val Ser Ala Ala
  65                  70                  75                  80

 gct ttc cag tgt gcc aag cca acc att gac tca tcc ctg aaa tca aag      288
 Ala Phe Gln Cys Ala Lys Pro Thr Ile Asp Ser Ser Leu Lys Ser Lys
                  85                  90                  95

 agc ctg act att ctg gaa gac agt agt tct gct ttc atc tct ccc caa      336
 Ser Leu Thr Ile Leu Glu Asp Ser Ser Ser Ala Phe Ile Ser Pro Gln
             100                 105                 110

 ggt ttc atg gca ccc ttt ggc tcc ctc act ttg aat atg aca gat cag      384
 Gly Phe Met Ala Pro Phe Gly Ser Leu Thr Leu Asn Met Thr Asp Gln
         115                 120                 125

 tct gga aat gaa gct aac atg gtc tgc agt att caa aag ccc tca agg      432
 Ser Gly Asn Glu Ala Asn Met Val Cys Ser Ile Gln Lys Pro Ser Arg
     130                 135                 140

 aca tca ccc att gca ttc act gaa gaa aat gac tac atc gtg cta aat      480
 Thr Ser Pro Ile Ala Phe Thr Glu Glu Asn Asp Tyr Ile Val Leu Asn
 145                 150                 155                 160

 act tca ttt tca aca ttt ttg gtg tgc aac ata gat tac ggt cac att      528
 Thr Ser Phe Ser Thr Phe Leu Val Cys Asn Ile Asp Tyr Gly His Ile
                 165                 170                 175

 cag cca gtg tgg caa att ttg gct ttg tac agt gat tct cct ctg ata      576
 Gln Pro Val Trp Gln Ile Leu Ala Leu Tyr Ser Asp Ser Pro Leu Ile
             180                 185                 190

 cta gaa agg agc cac ttg ctt agt gaa aca ccg cag ctc tat tac aaa      624
 Leu Glu Arg Ser His Leu Leu Ser Glu Thr Pro Gln Leu Tyr Tyr Lys
         195                 200                 205

 tat aaa cag gtg gct cct aag cct gaa gac att ttt acc aac ata gag      672
 Tyr Lys Gln Val Ala Pro Lys Pro Glu Asp Ile Phe Thr Asn Ile Glu
     210                 215                 220

 gca gat ctc aga gca gat ccc tct tgg tta atg caa gac caa att tcc      720
 Ala Asp Leu Arg Ala Asp Pro Ser Trp Leu Met Gln Asp Gln Ile Ser
 225                 230                 235                 240

 ttg cag ctg aac aga act gcc acc aca ttc agt aca tta cag atc cag      768
 Leu Gln Leu Asn Arg Thr Ala Thr Thr Phe Ser Thr Leu Gln Ile Gln
                 245                 250                 255

 tac tcc agt gat gct caa atc act tta cca aga gca gag atg agg cca      816
 Tyr Ser Ser Asp Ala Gln Ile Thr Leu Pro Arg Ala Glu Met Arg Pro
             260                 265                 270

 gtg aaa cac aaa tgg act atg att tca agg gat aac aat act aag ctg      864
 Val Lys His Lys Trp Thr Met Ile Ser Arg Asp Asn Asn Thr Lys Leu
         275                 280                 285

 gaa cat act gtc ttg gta ggt gga acc gtt ggc ctg aac tgc cca ggc      912
 Glu His Thr Val Leu Val Gly Gly Thr Val Gly Leu Asn Cys Pro Gly
     290                 295                 300

 caa gga gac ccc acc cca cac gtg gat tgg ctt cta gct gat gga agt      960
 Gln Gly Asp Pro Thr Pro His Val Asp Trp Leu Leu Ala Asp Gly Ser
 305                 310                 315                 320

 aaa gtg aga gcc cct tat gtc agt gag gat gga cgg atc cta ata gac     1008
 Lys Val Arg Ala Pro Tyr Val Ser Glu Asp Gly Arg Ile Leu Ile Asp
                 325                 330                 335

 aaa agt gga aaa ttg gaa ctc cag atg gct gat agt ttt gac aca ggc     1056
 Lys Ser Gly Lys Leu Glu Leu Gln Met Ala Asp Ser Phe Asp Thr Gly
             340                 345                 350

 gta tat cac tgt ata agc agc aat tat gat gat gca gat att ctc acc     1104
 Val Tyr His Cys Ile Ser Ser Asn Tyr Asp Asp Ala Asp Ile Leu Thr
         355                 360                 365

 tat agg ata act gtg gta gaa cct ttg gtc gaa gcc tat cag gaa aat     1152
 Tyr Arg Ile Thr Val Val Glu Pro Leu Val Glu Ala Tyr Gln Glu Asn
     370                 375                 380

 ggg att cat cac aca gtt ttc att ggt gaa aca ctt gat ctt cca tgc     1200
 Gly Ile His His Thr Val Phe Ile Gly Glu Thr Leu Asp Leu Pro Cys
 385                 390                 395                 400

 cat tct act ggt atc cca gat gcc tct att agc tgg gtt att cca gga     1248
 His Ser Thr Gly Ile Pro Asp Ala Ser Ile Ser Trp Val Ile Pro Gly
                 405                 410                 415

 aac aat gtg ctc tat cag tca tca aga gac aag aaa gtt cta aac aat     1296
 Asn Asn Val Leu Tyr Gln Ser Ser Arg Asp Lys Lys Val Leu Asn Asn
             420                 425                 430

 ggc aca tta aga ata tta cag gtc acc ccg aaa gac caa ggt tat tat     1344
 Gly Thr Leu Arg Ile Leu Gln Val Thr Pro Lys Asp Gln Gly Tyr Tyr
         435                 440                 445

 cgc tgt gtg gca gcc aac cca tca ggg gtt gat ttt ttg att ttc caa     1392
 Arg Cys Val Ala Ala Asn Pro Ser Gly Val Asp Phe Leu Ile Phe Gln
     450                 455                 460

 gtt tca gtc aag atg aaa gga caa agg ccc ttg gag cat gat gga gaa     1440
 Val Ser Val Lys Met Lys Gly Gln Arg Pro Leu Glu His Asp Gly Glu
 465                 470                 475                 480

 aca gag gga tct gga ctt gat gag tcc aat cct att gct cat ctt aag     1488
 Thr Glu Gly Ser Gly Leu Asp Glu Ser Asn Pro Ile Ala His Leu Lys
                 485                 490                 495

 gag cca cca ggt gca caa ctc cgt aca tct gct ctg atg gag gct gag     1536
 Glu Pro Pro Gly Ala Gln Leu Arg Thr Ser Ala Leu Met Glu Ala Glu
             500                 505                 510

 gtt gga aaa cac acc tca agc aca agt aag agg cac aac tat cgg gaa     1584
 Val Gly Lys His Thr Ser Ser Thr Ser Lys Arg His Asn Tyr Arg Glu
         515                 520                 525

 tta aca ctc cag cga cgt gga gat tca aca cat cga cgt ttt agg gag     1632
 Leu Thr Leu Gln Arg Arg Gly Asp Ser Thr His Arg Arg Phe Arg Glu
     530                 535                 540

 aat agg agg cat ttc cct ccc tct gct agg aga att gac cca caa cat     1680
 Asn Arg Arg His Phe Pro Pro Ser Ala Arg Arg Ile Asp Pro Gln His
 545                 550                 555                 560

 tgg gcg gca ctg ttg gag aaa gct aaa aag aat gct atg cca gac aag     1728
 Trp Ala Ala Leu Leu Glu Lys Ala Lys Lys Asn Ala Met Pro Asp Lys
                 565                 570                 575

 cga gaa aat acc aca gtg agc cca ccc cca gtg gtc acc caa ctc cca     1776
 Arg Glu Asn Thr Thr Val Ser Pro Pro Pro Val Val Thr Gln Leu Pro
             580                 585                 590

 aac ata cct ggt gaa gaa gac gat tcc tca ggc atg ctc gct cta cat     1824
 Asn Ile Pro Gly Glu Glu Asp Asp Ser Ser Gly Met Leu Ala Leu His
         595                 600                 605

 gag gaa ttt atg gtc ccg gcc act aaa gct ttg aac ctt cca gca agg     1872
 Glu Glu Phe Met Val Pro Ala Thr Lys Ala Leu Asn Leu Pro Ala Arg
     610                 615                 620

 aca gtg act gct gac tcc aga aca ata tct gat agt cct atg aca aac     1920
 Thr Val Thr Ala Asp Ser Arg Thr Ile Ser Asp Ser Pro Met Thr Asn
 625                 630                 635                 640

 ata aat tat ggc aca gaa ttc tct cct gtt gtg aat tca caa ata cta     1968
 Ile Asn Tyr Gly Thr Glu Phe Ser Pro Val Val Asn Ser Gln Ile Leu
                 645                 650                 655

 cca cct gaa gaa ccc aca gat ttc aaa ctg tct act gct att aaa act     2016
 Pro Pro Glu Glu Pro Thr Asp Phe Lys Leu Ser Thr Ala Ile Lys Thr
             660                 665                 670

 aca gcc atg tca aag aat ata aac cca acc atg tca agc caa ata caa     2064
 Thr Ala Met Ser Lys Asn Ile Asn Pro Thr Met Ser Ser Gln Ile Gln
         675                 680                 685

 ggc aca acc aat caa cat tca tcc act gtc ttt cca ctg cta ctt gga     2112
 Gly Thr Thr Asn Gln His Ser Ser Thr Val Phe Pro Leu Leu Leu Gly
     690                 695                 700

 gca act gaa ttt cag gac tct gac cag atg gga aga gga aga gag cat     2160
 Ala Thr Glu Phe Gln Asp Ser Asp Gln Met Gly Arg Gly Arg Glu His
 705                 710                 715                 720

 ttc caa agt aga ccc cca ata aca gta agg act atg atc aaa gat gtc     2208
 Phe Gln Ser Arg Pro Pro Ile Thr Val Arg Thr Met Ile Lys Asp Val
                 725                 730                 735

 aat gtc aaa atg ctt agt agc acc acc aac aaa cta tta tta gag tca     2256
 Asn Val Lys Met Leu Ser Ser Thr Thr Asn Lys Leu Leu Leu Glu Ser
             740                 745                 750

 gta aat acc aca aat agt cat cag aca tct gta aga gaa gtg agt gaa     2304
 Val Asn Thr Thr Asn Ser His Gln Thr Ser Val Arg Glu Val Ser Glu
         755                 760                 765

 ccc agg cac aat cac ttc tat tct cac act act caa ata ctt agc acc     2352
 Pro Arg His Asn His Phe Tyr Ser His Thr Thr Gln Ile Leu Ser Thr
     770                 775                 780

 tcc acg ttc cct tca gat cca cac aca gct gct cat tct cag ttt ccg     2400
 Ser Thr Phe Pro Ser Asp Pro His Thr Ala Ala His Ser Gln Phe Pro
 785                 790                 795                 800

 atc cct aga aat agt aca gtt aac atc ccg ctg ttc aga cgc ttt ggg     2448
 Ile Pro Arg Asn Ser Thr Val Asn Ile Pro Leu Phe Arg Arg Phe Gly
                 805                 810                 815

 agg cag agg aaa att ggc gga agg ggg cgg att atc agc cca tat aga     2496
 Arg Gln Arg Lys Ile Gly Gly Arg Gly Arg Ile Ile Ser Pro Tyr Arg
             820                 825                 830

 act cca gtt ctg cga cgg cat aga tac agc att ttc agg tca aca acc     2544
 Thr Pro Val Leu Arg Arg His Arg Tyr Ser Ile Phe Arg Ser Thr Thr
         835                 840                 845

 aga ggt tct tct gaa aaa agc act act gca ttc tca gcc aca gtg ctc     2592
 Arg Gly Ser Ser Glu Lys Ser Thr Thr Ala Phe Ser Ala Thr Val Leu
     850                 855                 860

 aat gtg aca tgt ctg tcc tgt ctt ccc agg gag agg ctc acc act gcc     2640
 Asn Val Thr Cys Leu Ser Cys Leu Pro Arg Glu Arg Leu Thr Thr Ala
 865                 870                 875                 880

 aca gca gca ttg tct ttt cca agt gct gct ccc atc acc ttc ccc aaa     2688
 Thr Ala Ala Leu Ser Phe Pro Ser Ala Ala Pro Ile Thr Phe Pro Lys
                 885                 890                 895

 gct gac att gct aga gtc cca tca gaa gag tct aca act cta gtc cag     2736
 Ala Asp Ile Ala Arg Val Pro Ser Glu Glu Ser Thr Thr Leu Val Gln
             900                 905                 910

 aat cca cta tta cta ctt gag aac aaa ccc agt gta gag aaa aca aca     2784
 Asn Pro Leu Leu Leu Leu Glu Asn Lys Pro Ser Val Glu Lys Thr Thr
         915                 920                 925

 ccc aca ata aaa tat ttc agg act gaa att tcc caa gtg act cca act     2832
 Pro Thr Ile Lys Tyr Phe Arg Thr Glu Ile Ser Gln Val Thr Pro Thr
     930                 935                 940

 ggt gca gtc atg aca tat gct cca aca tcc ata ccc atg gaa aaa act     2880
 Gly Ala Val Met Thr Tyr Ala Pro Thr Ser Ile Pro Met Glu Lys Thr
 945                 950                 955                 960

 cac aaa gta aac gcc agt tac cca cgt gtg tct agc acc aat gaa gct     2928
 His Lys Val Asn Ala Ser Tyr Pro Arg Val Ser Ser Thr Asn Glu Ala
                 965                 970                 975

 aaa aga gat tca gtg att aca tcg tca ctt tca ggt gct atc acc aag     2976
 Lys Arg Asp Ser Val Ile Thr Ser Ser Leu Ser Gly Ala Ile Thr Lys
             980                 985                 990

 cca cca atg act att ata gcc att aca agg ttt tca aga agg aaa att     3024
 Pro Pro Met Thr Ile Ile Ala Ile Thr Arg Phe Ser Arg Arg Lys Ile
         995                1000                1005

 ccc tgg caa cag aac ttt gta aat aac cat aac cca aaa ggc aga tta     3072
 Pro Trp Gln Gln Asn Phe Val Asn Asn His Asn Pro Lys Gly Arg Leu
    1010                1015                1020

 agg aat caa cat aaa gtt agt tta caa aaa agc aca gct gtg atg ctt     3120
 Arg Asn Gln His Lys Val Ser Leu Gln Lys Ser Thr Ala Val Met Leu
1025                1030                1035                1040

 cct aaa aca tct cct gct tta ccc aga gac aaa gtc tcc cct ttc cat     3168
 Pro Lys Thr Ser Pro Ala Leu Pro Arg Asp Lys Val Ser Pro Phe His
                1045                1050                1055

 ttc acc aca ctt tca aca agt gtg atg caa att cca tct aat acc ttg     3216
 Phe Thr Thr Leu Ser Thr Ser Val Met Gln Ile Pro Ser Asn Thr Leu
            1060                1065                1070

 act acc gct cac cac act acg acc aaa aca cac aat cct gga agt ctt     3264
 Thr Thr Ala His His Thr Thr Thr Lys Thr His Asn Pro Gly Ser Leu
        1075                1080                1085

 cca aca aag aag gag ctt ccc ttc cca ccc ctt aac cct atg ctt cct     3312
 Pro Thr Lys Lys Glu Leu Pro Phe Pro Pro Leu Asn Pro Met Leu Pro
    1090                1095                1100

 agt att ata agc aaa gac tca agt aca aaa agc atc ata tca acg caa     3360
 Ser Ile Ile Ser Lys Asp Ser Ser Thr Lys Ser Ile Ile Ser Thr Gln
1105                1110                1115                1120

 aca gca ata cca gca aca act cct acc ttc cct gca tct gtc atc act     3408
 Thr Ala Ile Pro Ala Thr Thr Pro Thr Phe Pro Ala Ser Val Ile Thr
                1125                1130                1135

 tat gaa acc caa aca gag aga tct aga gca caa aca ata caa aga gaa     3456
 Tyr Glu Thr Gln Thr Glu Arg Ser Arg Ala Gln Thr Ile Gln Arg Glu
            1140                1145                1150

 cag gag cct caa aag aag aac agg act gac cca aac atc tct cca gac     3504
 Gln Glu Pro Gln Lys Lys Asn Arg Thr Asp Pro Asn Ile Ser Pro Asp
        1155                1160                1165

 cag agt tct ggc ttc act aca ccc act gct atg aca cct cct gtt cta     3552
 Gln Ser Ser Gly Phe Thr Thr Pro Thr Ala Met Thr Pro Pro Val Leu
    1170                1175                1180

 acc aca gcc gaa act tca gtc aag ccc agt gtc tct gca ttc act cat     3600
 Thr Thr Ala Glu Thr Ser Val Lys Pro Ser Val Ser Ala Phe Thr His
1185                1190                1195                1200

 tcc cca cca gaa aac aca act ggg att tca agc aca atc agt ttt cat     3648
 Ser Pro Pro Glu Asn Thr Thr Gly Ile Ser Ser Thr Ile Ser Phe His
                1205                1210                1215

 tca aga act ctt aat ctg aca gat gtg att gaa gaa cta gcc caa gca     3696
 Ser Arg Thr Leu Asn Leu Thr Asp Val Ile Glu Glu Leu Ala Gln Ala
            1220                1225                1230

 agt act cag act ttg aag agc aca att gct tct gaa aca act ttg tcc     3744
 Ser Thr Gln Thr Leu Lys Ser Thr Ile Ala Ser Glu Thr Thr Leu Ser
        1235                1240                1245

 agc aaa tca cac cag agt acc aca act agg aaa gca atc att aga cac     3792
 Ser Lys Ser His Gln Ser Thr Thr Thr Arg Lys Ala Ile Ile Arg His
    1250                1255                1260

 tca acc ata cca cca ttc ttg agc agc agt gct act cta atg cca gtt     3840
 Ser Thr Ile Pro Pro Phe Leu Ser Ser Ser Ala Thr Leu Met Pro Val
1265                1270                1275                1280

 ccc atc tcc cct ccc ttt act cag aga gca gtt act gac aac gtg gcg     3888
 Pro Ile Ser Pro Pro Phe Thr Gln Arg Ala Val Thr Asp Asn Val Ala
                1285                1290                1295

 act ccc att tcc ggg ctt atg aca aat aca gtg gtc aag ctg cac gaa     3936
 Thr Pro Ile Ser Gly Leu Met Thr Asn Thr Val Val Lys Leu His Glu
            1300                1305                1310

 tcc tca agg cac aat gct aaa cca cag caa tta gta gca gag gtt gca     3984
 Ser Ser Arg His Asn Ala Lys Pro Gln Gln Leu Val Ala Glu Val Ala
        1315                1320                1325

 aca tcc ccc aag gtt cac cca aat gcc aag ttc aca att gga acc act     4032
 Thr Ser Pro Lys Val His Pro Asn Ala Lys Phe Thr Ile Gly Thr Thr
    1330                1335                1340

 cac ttc atc tac tct aat ctg tta cat tct act ccc atg cca gca cta     4080
 His Phe Ile Tyr Ser Asn Leu Leu His Ser Thr Pro Met Pro Ala Leu
1345                1350                1355                1360

 aca aca gtt aaa tca cag aat tct aaa tta act cca tct ccc tgg gca     4128
 Thr Thr Val Lys Ser Gln Asn Ser Lys Leu Thr Pro Ser Pro Trp Ala
                1365                1370                1375

 gaa aac caa ttt tgg cac aaa cca tac tca gaa att gct gaa aaa ggc     4176
 Glu Asn Gln Phe Trp His Lys Pro Tyr Ser Glu Ile Ala Glu Lys Gly
            1380                1385                1390

 aaa aag cca gaa gta agc atg ttg gct act aca ggc ctg tcc gag gcc     4224
 Lys Lys Pro Glu Val Ser Met Leu Ala Thr Thr Gly Leu Ser Glu Ala
        1395                1400                1405

 acc act ctt gtt tca gat tgg gat gga cag aag aac aca aag aag agt     4272
 Thr Thr Leu Val Ser Asp Trp Asp Gly Gln Lys Asn Thr Lys Lys Ser
    1410                1415                1420

 gac ttt gat aag aaa cca gtt caa gaa gca aca act tcc aaa ctc ctt     4320
 Asp Phe Asp Lys Lys Pro Val Gln Glu Ala Thr Thr Ser Lys Leu Leu
1425                1430                1435                1440

 ccc ttt gac tct ttg tct agg tat ata ttt gaa aag ccc agg ata gtt     4368
 Pro Phe Asp Ser Leu Ser Arg Tyr Ile Phe Glu Lys Pro Arg Ile Val
                1445                1450                1455

 gga gga aaa gct gca agt ttt act att cca gct aac tca gat gcc ttt     4416
 Gly Gly Lys Ala Ala Ser Phe Thr Ile Pro Ala Asn Ser Asp Ala Phe
            1460                1465                1470

 ctt ccc tgt gaa gct gtt gga aat ccc ctg ccc acc att cat tgg acc     4464
 Leu Pro Cys Glu Ala Val Gly Asn Pro Leu Pro Thr Ile His Trp Thr
        1475                1480                1485

 aga gtc cca tca gga ctt gat tta tct aag agg aaa cag aat agc agg     4512
 Arg Val Pro Ser Gly Leu Asp Leu Ser Lys Arg Lys Gln Asn Ser Arg
    1490                1495                1500

 gtc cag gtt ctc ccc aat ggt acc ctg tcc atc cag agg gtg gaa att     4560
 Val Gln Val Leu Pro Asn Gly Thr Leu Ser Ile Gln Arg Val Glu Ile
1505                1510                1515                1520

 cag gac cgc gga cag tac ttg tgt tcc gca tcc aat ctg ttt ggc aca     4608
 Gln Asp Arg Gly Gln Tyr Leu Cys Ser Ala Ser Asn Leu Phe Gly Thr
                1525                1530                1535

 gac cac ctt cat gtc acc ttg tct gtg gtt tcc tat cct ccc agg atc     4656
 Asp His Leu His Val Thr Leu Ser Val Val Ser Tyr Pro Pro Arg Ile
            1540                1545                1550

 ctg gag aga cgt acc aaa gag atc aca gtt cat tcc gga agc act gtg     4704
 Leu Glu Arg Arg Thr Lys Glu Ile Thr Val His Ser Gly Ser Thr Val
        1555                1560                1565

 gaa ctg aag tgc aga gca gaa ggt agg cca agc cct aca gtt acc tgg     4752
 Glu Leu Lys Cys Arg Ala Glu Gly Arg Pro Ser Pro Thr Val Thr Trp
    1570                1575                1580

 att ctt gca aac caa aca gtt gtc tca gaa tca tcc cag gga agt agg     4800
 Ile Leu Ala Asn Gln Thr Val Val Ser Glu Ser Ser Gln Gly Ser Arg
1585                1590                1595                1600

 cag gct gtg gtg acg gtt gac gga aca ttg gtc ctc cac aat ctc agt     4848
 Gln Ala Val Val Thr Val Asp Gly Thr Leu Val Leu His Asn Leu Ser
                1605                1610                1615

 att tat gac cgt ggc ttt tac aaa tgt gtg gcc agc aac cca ggt ggc     4896
 Ile Tyr Asp Arg Gly Phe Tyr Lys Cys Val Ala Ser Asn Pro Gly Gly
            1620                1625                1630

 cag gat tca ctg ctg gtt aaa ata caa gtc att gca gca cca cct gtt     4944
 Gln Asp Ser Leu Leu Val Lys Ile Gln Val Ile Ala Ala Pro Pro Val
        1635                1640                1645

 att cta gag caa agg agg caa gtc att gta ggc act tgg ggt gaa agt     4992
 Ile Leu Glu Gln Arg Arg Gln Val Ile Val Gly Thr Trp Gly Glu Ser
    1650                1655                1660

 tta aaa ctg ccc tgt act gca aaa gga act cct cag ccc agc gtt tac     5040
 Leu Lys Leu Pro Cys Thr Ala Lys Gly Thr Pro Gln Pro Ser Val Tyr
1665                1670                1675                1680

 tgg gtc ctc tct gat ggc act gaa gtg aaa cca tta cag ttt acc aat     5088
 Trp Val Leu Ser Asp Gly Thr Glu Val Lys Pro Leu Gln Phe Thr Asn
                1685                1690                1695

 tcc aag ttg ttc tta ttt tca aat ggg act ttg tat ata aga aac cta     5136
 Ser Lys Leu Phe Leu Phe Ser Asn Gly Thr Leu Tyr Ile Arg Asn Leu
            1700                1705                1710

 gcc tct tca gac agg ggc act tat gaa tgc att gct acc agt tcc act     5184
 Ala Ser Ser Asp Arg Gly Thr Tyr Glu Cys Ile Ala Thr Ser Ser Thr
        1715                1720                1725

 ggt tcg gag cga aga gta gta atg ctt aca atg gaa gag cga gtg acc     5232
 Gly Ser Glu Arg Arg Val Val Met Leu Thr Met Glu Glu Arg Val Thr
    1730                1735                1740

 agc ccc agg ata gaa gct gca tcc cag aaa agg act gaa gtg aat ttt     5280
 Ser Pro Arg Ile Glu Ala Ala Ser Gln Lys Arg Thr Glu Val Asn Phe
1745                1750                1755                1760

 ggg gac aaa tta cta ctg aac tgc tca gcc act ggg gag ccc aaa ccc     5328
 Gly Asp Lys Leu Leu Leu Asn Cys Ser Ala Thr Gly Glu Pro Lys Pro
                1765                1770                1775

 caa ata atg tgg agg tta cca tcc aag gct gtg gtc gac cag cag cat     5376
 Gln Ile Met Trp Arg Leu Pro Ser Lys Ala Val Val Asp Gln Gln His
            1780                1785                1790

 aga gtg ggc agc tgg atc cac gtc tac cct aat gga tcc ctg ttt att     5424
 Arg Val Gly Ser Trp Ile His Val Tyr Pro Asn Gly Ser Leu Phe Ile
        1795                1800                1805

 gga tca gta aca gaa aaa gac agt ggt gtc tac ttg tgt gtg gca aga     5472
 Gly Ser Val Thr Glu Lys Asp Ser Gly Val Tyr Leu Cys Val Ala Arg
    1810                1815                1820

 aac aaa atg ggg gat gat ctg ata ctg atg cat gtt agc cta aga ctg     5520
 Asn Lys Met Gly Asp Asp Leu Ile Leu Met His Val Ser Leu Arg Leu
1825                1830                1835                1840

 aaa cct gcc aaa att gac cac aag cag tat ttt aga aag caa gtg ctc     5568
 Lys Pro Ala Lys Ile Asp His Lys Gln Tyr Phe Arg Lys Gln Val Leu
                1845                1850                1855

 cat ggg aaa gat ttc caa gta gat tgc aaa gct tcc ggc tcc cca gtg     5616
 His Gly Lys Asp Phe Gln Val Asp Cys Lys Ala Ser Gly Ser Pro Val
            1860                1865                1870

 cca gag ata tct tgg agt ttg cct gat gga acc atg atc aac aat gca     5664
 Pro Glu Ile Ser Trp Ser Leu Pro Asp Gly Thr Met Ile Asn Asn Ala
        1875                1880                1885

 atg caa gcc gat gac agt ggc cac agg act agg aga tat acc ctt ttc     5712
 Met Gln Ala Asp Asp Ser Gly His Arg Thr Arg Arg Tyr Thr Leu Phe
    1890                1895                1900

 aac aat gga act tta tac ttc aac aaa gtt ggg gta gcg gag gaa gga     5760
 Asn Asn Gly Thr Leu Tyr Phe Asn Lys Val Gly Val Ala Glu Glu Gly
1905                1910                1915                1920

 gat tat act tgc tat gcc cag aac acc cta ggg aaa gat gaa atg aag     5808
 Asp Tyr Thr Cys Tyr Ala Gln Asn Thr Leu Gly Lys Asp Glu Met Lys
                1925                1930                1935

 gtc cac tta aca gtt ata aca gct gct ccc cgg ata agg cag agt aac     5856
 Val His Leu Thr Val Ile Thr Ala Ala Pro Arg Ile Arg Gln Ser Asn
            1940                1945                1950

 aaa acc aac aag aga atc aaa gct gga gac aca gct gtc ctt gac tgt     5904
 Lys Thr Asn Lys Arg Ile Lys Ala Gly Asp Thr Ala Val Leu Asp Cys
        1955                1960                1965

 gag gtc act ggg gat ccc aaa cca aaa ata ttt tgg ttg ctg cct tcc     5952
 Glu Val Thr Gly Asp Pro Lys Pro Lys Ile Phe Trp Leu Leu Pro Ser
    1970                1975                1980

 aat gac atg att tcc ttc tcc att gat agg tac aca ttt cat gcc aat     6000
 Asn Asp Met Ile Ser Phe Ser Ile Asp Arg Tyr Thr Phe His Ala Asn
1985                1990                1995                2000

 ggg tct ttg acc atc aac aaa gtg aaa ctg ctc gat tct gga gag tac     6048
 Gly Ser Leu Thr Ile Asn Lys Val Lys Leu Leu Asp Ser Gly Glu Tyr
                2005                2010                2015

 gta tgt gta gcc cga aat ccc agt ggg gat gac acc aaa atg tac aaa     6096
 Val Cys Val Ala Arg Asn Pro Ser Gly Asp Asp Thr Lys Met Tyr Lys
            2020                2025                2030

 ctg gat gtg gtc tct aaa cct cca tta atc aat ggt ctg tat aca aac     6144
 Leu Asp Val Val Ser Lys Pro Pro Leu Ile Asn Gly Leu Tyr Thr Asn
        2035                2040                2045

 aga act gtt att aaa gcc aca gct gtg aga cat tcc aaa aaa cac ttt     6192
 Arg Thr Val Ile Lys Ala Thr Ala Val Arg His Ser Lys Lys His Phe
    2050                2055                2060

 gac tgc aga gct gaa ggg aca cca tct cct gaa gtc atg tgg atc atg     6240
 Asp Cys Arg Ala Glu Gly Thr Pro Ser Pro Glu Val Met Trp Ile Met
2065                2070                2075                2080

 cca gac aat att ttc ctc aca gcc cca tac tat gga agc aga atc aca     6288
 Pro Asp Asn Ile Phe Leu Thr Ala Pro Tyr Tyr Gly Ser Arg Ile Thr
                2085                2090                2095

 gtc cat aaa aat gga acc ttg gaa att agg aat gtg agg ctt tca gat     6336
 Val His Lys Asn Gly Thr Leu Glu Ile Arg Asn Val Arg Leu Ser Asp
            2100                2105                2110

 tca gcc gac ttt atc tgt gtg gcc cga aat gaa ggt gga gag agc gtg     6384
 Ser Ala Asp Phe Ile Cys Val Ala Arg Asn Glu Gly Gly Glu Ser Val
        2115                2120                2125

 ttg gta gta cag tta gaa gta ctg gaa atg ctg aga aga ccg aca ttt     6432
 Leu Val Val Gln Leu Glu Val Leu Glu Met Leu Arg Arg Pro Thr Phe
    2130                2135                2140

 aga aat cca ttt aat gaa aaa ata gtt gcc cag ctg gga aag tcc aca     6480
 Arg Asn Pro Phe Asn Glu Lys Ile Val Ala Gln Leu Gly Lys Ser Thr
2145                2150                2155                2160

 gca ttg aat tgc tct gtt gat ggt aac cca cca cct gaa ata atc tgg     6528
 Ala Leu Asn Cys Ser Val Asp Gly Asn Pro Pro Pro Glu Ile Ile Trp
                2165                2170                2175

 att tta cca aat ggc aca cga ttt tcc aat gga cca caa agt tat cag     6576
 Ile Leu Pro Asn Gly Thr Arg Phe Ser Asn Gly Pro Gln Ser Tyr Gln
            2180                2185                2190

 tat ctg ata gca agc aat ggt tct ttt atc att tct aaa aca act cgg     6624
 Tyr Leu Ile Ala Ser Asn Gly Ser Phe Ile Ile Ser Lys Thr Thr Arg
        2195                2200                2205

 gag gat gca gga aaa tat cgc tgt gca gct agg aat aaa gtt ggc tat     6672
 Glu Asp Ala Gly Lys Tyr Arg Cys Ala Ala Arg Asn Lys Val Gly Tyr
    2210                2215                2220

 att gag aaa tta gtc ata tta gaa att ggc cag aag cca gtt att ctt     6720
 Ile Glu Lys Leu Val Ile Leu Glu Ile Gly Gln Lys Pro Val Ile Leu
2225                2230                2235                2240

 acc tat gca cca ggg aca gta aaa ggc atc agt gga gaa tct cta tca     6768
 Thr Tyr Ala Pro Gly Thr Val Lys Gly Ile Ser Gly Glu Ser Leu Ser
                2245                2250                2255

 ctg cat tgt gtg tct gat gga atc cct aag cca aat atc aaa tgg act     6816
 Leu His Cys Val Ser Asp Gly Ile Pro Lys Pro Asn Ile Lys Trp Thr
            2260                2265                2270

 atg cca agt ggt tat gta gta gac agg cct caa att aat ggg aaa tac     6864
 Met Pro Ser Gly Tyr Val Val Asp Arg Pro Gln Ile Asn Gly Lys Tyr
        2275                2280                2285

 ata ttg cat gac aat ggc acc tta gtc att aaa gaa gca aca gct tat     6912
 Ile Leu His Asp Asn Gly Thr Leu Val Ile Lys Glu Ala Thr Ala Tyr
    2290                2295                2300

 gac aga gga aac tat atc tgt aag gct caa aat agt gtt ggt cat aca     6960
 Asp Arg Gly Asn Tyr Ile Cys Lys Ala Gln Asn Ser Val Gly His Thr
2305                2310                2315                2320

 ctg att act gtt cca gta atg att gta gcc tac cct ccc cga att aca     7008
 Leu Ile Thr Val Pro Val Met Ile Val Ala Tyr Pro Pro Arg Ile Thr
                2325                2330                2335

 aat cgt cca ccc agg agt att gtc acc agg aca ggg gca gcc ttt cag     7056
 Asn Arg Pro Pro Arg Ser Ile Val Thr Arg Thr Gly Ala Ala Phe Gln
            2340                2345                2350

 ctc cac tgt gtg gcc ttg gga gtt ccc aag cca gaa atc acg tgg gag     7104
 Leu His Cys Val Ala Leu Gly Val Pro Lys Pro Glu Ile Thr Trp Glu
        2355                2360                2365

 atg cct gac cac tcc ctt ctc tca acg gca agt aaa gag agg aca cat     7152
 Met Pro Asp His Ser Leu Leu Ser Thr Ala Ser Lys Glu Arg Thr His
    2370                2375                2380

 gga agt gag cag ctt cac tta caa ggt acc cta gtc att cag aat ccc     7200
 Gly Ser Glu Gln Leu His Leu Gln Gly Thr Leu Val Ile Gln Asn Pro
2385                2390                2395                2400

 caa acc tcc gat tct ggg ata tac aaa tgc aca gca aag aac cca ctt     7248
 Gln Thr Ser Asp Ser Gly Ile Tyr Lys Cys Thr Ala Lys Asn Pro Leu
                2405                2410                2415

 ggt agt gat tat gca gca acg tat att caa gta atc tga catgaaataa      7297
 Gly Ser Asp Tyr Ala Ala Thr Tyr Ile Gln Val Ile 
            2420                2425

 taaagtcaac aacatctggg cagaatttat tttttggaag aagtttaatc aaaggcagcc   7357

 ataggcatgt aaatgaattt gaatacattt acagtattaa atttacaatg aacatgcaaa   7417

 ataaaaggac ttgtaaataa atgcattatg aactgatgat actgatttat ttaatggatc   7477

 tcaaaacaaa cttttaactt aaggcacttt tattttgcca acaaataaca ataaacaaac   7537

 attgaaacgg ttcactataa aataacaaat ggctaatgta cctgaatttt tcagtaaaaa   7597

 aatgaacttc taataccagt tgcctagtgt ccacctccta tcaatgttac aagcatggca   7657

 ctcagaacag agacaatgga aaatattaaa tctgcaatct ttatgatgta aatttaccat   7717

 cctgatgtat aaatattttg tggtttataa atttttttgc taaaacctac agaaaataag   7777

 cactgaactg tcttatgatt caccatttgt tcacactgaa aattttcatt gatggggaat   7837

 acaaaaatgt tttaataact gcatttaaaa ataaatgcag gctcactttt ccacatgtaa   7897

 aaagcaatgt aatacctgca catcataaaa tgtgaaaagg gggttatttt tgtccaaata   7957

 cacccattaa aaaggtttta aaaataaaaa aaaaaaaaa                          7996




      <210> 130
      <211> 8782
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (202)..(8073)

      <400> 130
 cttgatcata aagcgcagtg tgaggccagc agcacacact atagttttgt aaagagtgca     60

 tatgaccaca aagggtagga atggaattga ccacttacga cccttaaaga aggtctccca    120

 gattcccaga gtgagtgtgt ggtggtcctg ggactttgct ccaccactct ttataactct    180

 gaggtatgat gttttttcag g  atg aag gta aaa ggc aga gga atc acc tgc     231
                          Met Lys Val Lys Gly Arg Gly Ile Thr Cys
                            1               5                  10

 ttg ctg gtc tcc ttt gct gtg atc tgc ctg gtc gcc acc cct ggg ggc      279
 Leu Leu Val Ser Phe Ala Val Ile Cys Leu Val Ala Thr Pro Gly Gly
                  15                  20                  25

 aag gcc tgt cct cgc cgc tgt gcc tgt tat atg cct acg gag gta cac      327
 Lys Ala Cys Pro Arg Arg Cys Ala Cys Tyr Met Pro Thr Glu Val His
              30                  35                  40

 tgc aca ttt cgg tac ctg act tcc atc cca gac agc atc ccg ccc aat      375
 Cys Thr Phe Arg Tyr Leu Thr Ser Ile Pro Asp Ser Ile Pro Pro Asn
          45                  50                  55

 gtg gaa cgc atc aat tta gga tac aac agc ttg gtt aga ttg atg gaa      423
 Val Glu Arg Ile Asn Leu Gly Tyr Asn Ser Leu Val Arg Leu Met Glu
      60                  65                  70

 aca gat ttt tct ggc ctg acc aaa ctg gag tta ctc atg ctt cac agc      471
 Thr Asp Phe Ser Gly Leu Thr Lys Leu Glu Leu Leu Met Leu His Ser
  75                  80                  85                  90

 aat ggc att cac aca atc cct gac aag acc ttc tca gat ttg cag gcc      519
 Asn Gly Ile His Thr Ile Pro Asp Lys Thr Phe Ser Asp Leu Gln Ala
                  95                 100                 105

 ttg cag gtc tta aaa atg agc tat aat aaa gtc cga aaa ctt cag aaa      567
 Leu Gln Val Leu Lys Met Ser Tyr Asn Lys Val Arg Lys Leu Gln Lys
             110                 115                 120

 gat act ttt tat ggc ctc agg agc ttg aca cga ttg cac atg gac cac      615
 Asp Thr Phe Tyr Gly Leu Arg Ser Leu Thr Arg Leu His Met Asp His
         125                 130                 135

 aac aat att gag ttt ata aac cca gag gtt ttt tat ggg ctc aac ttt      663
 Asn Asn Ile Glu Phe Ile Asn Pro Glu Val Phe Tyr Gly Leu Asn Phe
     140                 145                 150

 ctc cgc ctg gtg cac ttg gaa gga aat cag ctc act aag ctc cac cca      711
 Leu Arg Leu Val His Leu Glu Gly Asn Gln Leu Thr Lys Leu His Pro
 155                 160                 165                 170

 gat aca ttt gtc tct ttg agc tac ctc cag ata ttt aaa atc tct ttc      759
 Asp Thr Phe Val Ser Leu Ser Tyr Leu Gln Ile Phe Lys Ile Ser Phe
                 175                 180                 185

 att aag ttc cta tac ttg tct gat aac ttc ctg acc tcc ctc cct caa      807
 Ile Lys Phe Leu Tyr Leu Ser Asp Asn Phe Leu Thr Ser Leu Pro Gln
             190                 195                 200

 gag atg gtc tcc tat atg cct gac cta gac agc ctt tac ctg cat gga      855
 Glu Met Val Ser Tyr Met Pro Asp Leu Asp Ser Leu Tyr Leu His Gly
         205                 210                 215

 aac cca tgg acc tgt gat tgc cat tta aag tgg ttg tct gac tgg ata      903
 Asn Pro Trp Thr Cys Asp Cys His Leu Lys Trp Leu Ser Asp Trp Ile
     220                 225                 230

 cag gag aag cca gat gta ata aaa tgc aaa aaa gat aga agt ccc tct      951
 Gln Glu Lys Pro Asp Val Ile Lys Cys Lys Lys Asp Arg Ser Pro Ser
 235                 240                 245                 250

 agt gct cag cag tgt cca ctt tgc atg aac cct agg act tct aaa ggc      999
 Ser Ala Gln Gln Cys Pro Leu Cys Met Asn Pro Arg Thr Ser Lys Gly
                 255                 260                 265

 aag ccg tta gct atg gtc tca gct gca gct ttc cag tgt gcc aag cca     1047
 Lys Pro Leu Ala Met Val Ser Ala Ala Ala Phe Gln Cys Ala Lys Pro
             270                 275                 280

 acc att gac tca tcc ctg aaa tca aag agc ctg act att ctg gaa gac     1095
 Thr Ile Asp Ser Ser Leu Lys Ser Lys Ser Leu Thr Ile Leu Glu Asp
         285                 290                 295

 agt agt tct gct ttc atc tct ccc caa ggt ttc atg gca ccc ttt ggc     1143
 Ser Ser Ser Ala Phe Ile Ser Pro Gln Gly Phe Met Ala Pro Phe Gly
     300                 305                 310

 tcc ctc act ttg aat atg aca gat cag tct gga aat gaa gct aac atg     1191
 Ser Leu Thr Leu Asn Met Thr Asp Gln Ser Gly Asn Glu Ala Asn Met
 315                 320                 325                 330

 gtc tgc agt att caa aag ccc tca agg aca tca ccc att gca ttc act     1239
 Val Cys Ser Ile Gln Lys Pro Ser Arg Thr Ser Pro Ile Ala Phe Thr
                 335                 340                 345

 gaa gaa aat gac tac atc gtg cta aat act tca ttt tca aca ttt ttg     1287
 Glu Glu Asn Asp Tyr Ile Val Leu Asn Thr Ser Phe Ser Thr Phe Leu
             350                 355                 360

 gtg tgc aac ata gat tac ggt cac att cag cca gtg tgg caa att ttg     1335
 Val Cys Asn Ile Asp Tyr Gly His Ile Gln Pro Val Trp Gln Ile Leu
         365                 370                 375

 gct ttg tac agt gat tct cct ctg ata cta gaa agg agc cac ttg ctt     1383
 Ala Leu Tyr Ser Asp Ser Pro Leu Ile Leu Glu Arg Ser His Leu Leu
     380                 385                 390

 agt gaa aca ccg cag ctc tat tac aaa tat aaa cag gtg gct cct aag     1431
 Ser Glu Thr Pro Gln Leu Tyr Tyr Lys Tyr Lys Gln Val Ala Pro Lys
 395                 400                 405                 410

 cct gaa gac att ttt acc aac ata gag gca gat ctc aga gca gat ccc     1479
 Pro Glu Asp Ile Phe Thr Asn Ile Glu Ala Asp Leu Arg Ala Asp Pro
                 415                 420                 425

 tct tgg tta atg caa gac caa att tcc ttg cag ctg aac aga act gcc     1527
 Ser Trp Leu Met Gln Asp Gln Ile Ser Leu Gln Leu Asn Arg Thr Ala
             430                 435                 440

 acc aca ttc agt aca tta cag atc cag tac tcc agt gat gct caa atc     1575
 Thr Thr Phe Ser Thr Leu Gln Ile Gln Tyr Ser Ser Asp Ala Gln Ile
         445                 450                 455

 act tta cca aga gca gag atg agg cca gtg aaa cac aaa tgg act atg     1623
 Thr Leu Pro Arg Ala Glu Met Arg Pro Val Lys His Lys Trp Thr Met
     460                 465                 470

 att tca agg gat aac aat act aag ctg gaa cat act gtc ttg gta ggt     1671
 Ile Ser Arg Asp Asn Asn Thr Lys Leu Glu His Thr Val Leu Val Gly
 475                 480                 485                 490

 gga acc gtt ggc ctg aac tgc cca ggc caa gga gac ccc acc cca cac     1719
 Gly Thr Val Gly Leu Asn Cys Pro Gly Gln Gly Asp Pro Thr Pro His
                 495                 500                 505

 gtg gat tgg ctt cta gct gat gga agt aaa gtg aga gcc cct tat gtc     1767
 Val Asp Trp Leu Leu Ala Asp Gly Ser Lys Val Arg Ala Pro Tyr Val
             510                 515                 520

 agt gag gat gga cgg atc cta ata gac aaa agt gga aaa ttg gaa ctc     1815
 Ser Glu Asp Gly Arg Ile Leu Ile Asp Lys Ser Gly Lys Leu Glu Leu
         525                 530                 535

 cag atg gct gat agt ttt gac aca ggc gta tat cac tgt ata agc agc     1863
 Gln Met Ala Asp Ser Phe Asp Thr Gly Val Tyr His Cys Ile Ser Ser
     540                 545                 550

 aat tat gat gat gca gat att ctc acc tat agg ata act gtg gta gaa     1911
 Asn Tyr Asp Asp Ala Asp Ile Leu Thr Tyr Arg Ile Thr Val Val Glu
 555                 560                 565                 570

 cct ttg gtc gaa gcc tat cag gaa aat ggg att cat cac aca gtt ttc     1959
 Pro Leu Val Glu Ala Tyr Gln Glu Asn Gly Ile His His Thr Val Phe
                 575                 580                 585

 att ggt gaa aca ctt gat ctt cca tgc cat tct act ggt atc cca gat     2007
 Ile Gly Glu Thr Leu Asp Leu Pro Cys His Ser Thr Gly Ile Pro Asp
             590                 595                 600

 gcc tct att agc tgg gtt att cca gga aac aat gtg ctc tat cag tca     2055
 Ala Ser Ile Ser Trp Val Ile Pro Gly Asn Asn Val Leu Tyr Gln Ser
         605                 610                 615

 tca aga gac aag aaa gtt cta aac aat ggc aca tta aga ata tta cag     2103
 Ser Arg Asp Lys Lys Val Leu Asn Asn Gly Thr Leu Arg Ile Leu Gln
     620                 625                 630

 gtc acc ccg aaa gac caa ggt tat tat cgc tgt gtg gca gcc aac cca     2151
 Val Thr Pro Lys Asp Gln Gly Tyr Tyr Arg Cys Val Ala Ala Asn Pro
 635                 640                 645                 650

 tca ggg gtt gat ttt ttg att ttc caa gtt tca gtc aag atg aaa gga     2199
 Ser Gly Val Asp Phe Leu Ile Phe Gln Val Ser Val Lys Met Lys Gly
                 655                 660                 665

 caa agg ccc ttg gag cat gat gga gaa aca gag gga tct gga ctt gat     2247
 Gln Arg Pro Leu Glu His Asp Gly Glu Thr Glu Gly Ser Gly Leu Asp
             670                 675                 680

 gag tcc aat cct att gct cat ctt aag gag cca cca ggt gca caa ctc     2295
 Glu Ser Asn Pro Ile Ala His Leu Lys Glu Pro Pro Gly Ala Gln Leu
         685                 690                 695

 cgt aca tct gct ctg atg gag gct gag gtt gga aaa cac acc tca agc     2343
 Arg Thr Ser Ala Leu Met Glu Ala Glu Val Gly Lys His Thr Ser Ser
     700                 705                 710

 aca agt aag agg cac aac tat cgg gaa tta aca ctc cag cga cgt gga     2391
 Thr Ser Lys Arg His Asn Tyr Arg Glu Leu Thr Leu Gln Arg Arg Gly
 715                 720                 725                 730

 gat tca aca cat cga cgt ttt agg gag aat agg agg cat ttc cct ccc     2439
 Asp Ser Thr His Arg Arg Phe Arg Glu Asn Arg Arg His Phe Pro Pro
                 735                 740                 745

 tct gct agg aga att gac cca caa cat tgg gcg gca ctg ttg gag aaa     2487
 Ser Ala Arg Arg Ile Asp Pro Gln His Trp Ala Ala Leu Leu Glu Lys
             750                 755                 760

 gct aaa aag aat gct atg cca gac aag cga gaa aat acc aca gtg agc     2535
 Ala Lys Lys Asn Ala Met Pro Asp Lys Arg Glu Asn Thr Thr Val Ser
         765                 770                 775

 cca ccc cca gtg gtc acc caa ctc cca aac ata cct ggt gaa gaa gac     2583
 Pro Pro Pro Val Val Thr Gln Leu Pro Asn Ile Pro Gly Glu Glu Asp
     780                 785                 790

 gat tcc tca ggc atg ctc gct cta cat gag gaa ttt atg gtc ccg gcc     2631
 Asp Ser Ser Gly Met Leu Ala Leu His Glu Glu Phe Met Val Pro Ala
 795                 800                 805                 810

 act aaa gct ttg aac ctt cca gca agg aca gtg act gct gac tcc aga     2679
 Thr Lys Ala Leu Asn Leu Pro Ala Arg Thr Val Thr Ala Asp Ser Arg
                 815                 820                 825

 aca ata tct gat agt cct atg aca aac ata aat tat ggc aca gaa ttc     2727
 Thr Ile Ser Asp Ser Pro Met Thr Asn Ile Asn Tyr Gly Thr Glu Phe
             830                 835                 840

 tct cct gtt gtg aat tca caa ata cta cca cct gaa gaa ccc aca gat     2775
 Ser Pro Val Val Asn Ser Gln Ile Leu Pro Pro Glu Glu Pro Thr Asp
         845                 850                 855

 ttc aaa ctg tct act gct att aaa act aca gcc atg tca aag aat ata     2823
 Phe Lys Leu Ser Thr Ala Ile Lys Thr Thr Ala Met Ser Lys Asn Ile
     860                 865                 870

 aac cca acc atg tca agc caa ata caa ggc aca acc aat caa cat tca     2871
 Asn Pro Thr Met Ser Ser Gln Ile Gln Gly Thr Thr Asn Gln His Ser
 875                 880                 885                 890

 tcc act gtc ttt cca ctg cta ctt gga gca act gaa ttt cag gac tct     2919
 Ser Thr Val Phe Pro Leu Leu Leu Gly Ala Thr Glu Phe Gln Asp Ser
                 895                 900                 905

 gac cag atg gga aga gga aga gag cat ttc caa agt aga ccc cca ata     2967
 Asp Gln Met Gly Arg Gly Arg Glu His Phe Gln Ser Arg Pro Pro Ile
             910                 915                 920

 aca gta agg act atg atc aaa gat gtc aat gtc aaa atg ctt agt agc     3015
 Thr Val Arg Thr Met Ile Lys Asp Val Asn Val Lys Met Leu Ser Ser
         925                 930                 935

 acc acc aac aaa cta tta tta gag tca gta aat acc aca aat agt cat     3063
 Thr Thr Asn Lys Leu Leu Leu Glu Ser Val Asn Thr Thr Asn Ser His
     940                 945                 950

 cag aca tct gta aga gaa gtg agt gaa ccc agg cac aat cac ttc tat     3111
 Gln Thr Ser Val Arg Glu Val Ser Glu Pro Arg His Asn His Phe Tyr
 955                 960                 965                 970

 tct cac act act caa ata ctt agc acc tcc acg ttc cct tca gat cca     3159
 Ser His Thr Thr Gln Ile Leu Ser Thr Ser Thr Phe Pro Ser Asp Pro
                 975                 980                 985

 cac aca gct gct cat tct cag ttt ccg atc cct aga aat agt aca gtt     3207
 His Thr Ala Ala His Ser Gln Phe Pro Ile Pro Arg Asn Ser Thr Val
             990                 995                1000

 aac atc ccg ctg ttc aga cgc ttt ggg agg cag agg aaa att ggc gga     3255
 Asn Ile Pro Leu Phe Arg Arg Phe Gly Arg Gln Arg Lys Ile Gly Gly
        1005                1010                1015

 agg ggg cgg att atc agc cca tat aga act cca gtt ctg cga cgg cat     3303
 Arg Gly Arg Ile Ile Ser Pro Tyr Arg Thr Pro Val Leu Arg Arg His
    1020                1025                1030

 aga tac agc att ttc agg tca aca acc aga ggt tct tct gaa aaa agc     3351
 Arg Tyr Ser Ile Phe Arg Ser Thr Thr Arg Gly Ser Ser Glu Lys Ser
1035                1040                1045                1050

 act act gca ttc tca gcc aca gtg ctc aat gtg aca tgt ctg tcc tgt     3399
 Thr Thr Ala Phe Ser Ala Thr Val Leu Asn Val Thr Cys Leu Ser Cys
                1055                1060                1065

 ctt ccc agg gag agg ctc acc act gcc aca gca gca ttg tct ttt cca     3447
 Leu Pro Arg Glu Arg Leu Thr Thr Ala Thr Ala Ala Leu Ser Phe Pro
            1070                1075                1080

 agt gct gct ccc atc acc ttc ccc aaa gct gac att gct aga gtc cca     3495
 Ser Ala Ala Pro Ile Thr Phe Pro Lys Ala Asp Ile Ala Arg Val Pro
        1085                1090                1095

 tca gaa gag tct aca act cta gtc cag aat cca cta tta cta ctt gag     3543
 Ser Glu Glu Ser Thr Thr Leu Val Gln Asn Pro Leu Leu Leu Leu Glu
    1100                1105                1110

 aac aaa ccc agt gta gag aaa aca aca ccc aca ata aaa tat ttc agg     3591
 Asn Lys Pro Ser Val Glu Lys Thr Thr Pro Thr Ile Lys Tyr Phe Arg
1115                1120                1125                1130

 act gaa att tcc caa gtg act cca act ggt gca gtc atg aca tat gct     3639
 Thr Glu Ile Ser Gln Val Thr Pro Thr Gly Ala Val Met Thr Tyr Ala
                1135                1140                1145

 cca aca tcc ata ccc atg gaa aaa act cac aaa gta aac gcc agt tac     3687
 Pro Thr Ser Ile Pro Met Glu Lys Thr His Lys Val Asn Ala Ser Tyr
            1150                1155                1160

 cca cgt gtg tct agc acc aat gaa gct aaa aga gat tca gtg att aca     3735
 Pro Arg Val Ser Ser Thr Asn Glu Ala Lys Arg Asp Ser Val Ile Thr
        1165                1170                1175

 tcg tca ctt tca ggt gct atc acc aag cca cca atg act att ata gcc     3783
 Ser Ser Leu Ser Gly Ala Ile Thr Lys Pro Pro Met Thr Ile Ile Ala
    1180                1185                1190

 att aca agg ttt tca aga agg aaa att ccc tgg caa cag aac ttt gta     3831
 Ile Thr Arg Phe Ser Arg Arg Lys Ile Pro Trp Gln Gln Asn Phe Val
1195                1200                1205                1210

 aat aac cat aac cca aaa ggc aga tta agg aat caa cat aaa gtt agt     3879
 Asn Asn His Asn Pro Lys Gly Arg Leu Arg Asn Gln His Lys Val Ser
                1215                1220                1225

 tta caa aaa agc aca gct gtg atg ctt cct aaa aca tct cct gct tta     3927
 Leu Gln Lys Ser Thr Ala Val Met Leu Pro Lys Thr Ser Pro Ala Leu
            1230                1235                1240

 ccc aga gac aaa gtc tcc cct ttc cat ttc acc aca ctt tca aca agt     3975
 Pro Arg Asp Lys Val Ser Pro Phe His Phe Thr Thr Leu Ser Thr Ser
        1245                1250                1255

 gtg atg caa att cca tct aat acc ttg act acc gct cac cac act acg     4023
 Val Met Gln Ile Pro Ser Asn Thr Leu Thr Thr Ala His His Thr Thr
    1260                1265                1270

 acc aaa aca cac aat cct gga agt ctt cca aca aag aag gag ctt ccc     4071
 Thr Lys Thr His Asn Pro Gly Ser Leu Pro Thr Lys Lys Glu Leu Pro
1275                1280                1285                1290

 ttc cca ccc ctt aac cct atg ctt cct agt att ata agc aaa gac tca     4119
 Phe Pro Pro Leu Asn Pro Met Leu Pro Ser Ile Ile Ser Lys Asp Ser
                1295                1300                1305

 agt aca aaa agc atc ata tca acg caa aca gca ata cca gca aca act     4167
 Ser Thr Lys Ser Ile Ile Ser Thr Gln Thr Ala Ile Pro Ala Thr Thr
            1310                1315                1320

 cct acc ttc cct gca tct gtc atc act tat gaa acc caa aca gag aga     4215
 Pro Thr Phe Pro Ala Ser Val Ile Thr Tyr Glu Thr Gln Thr Glu Arg
        1325                1330                1335

 tct aga gca caa aca ata caa aga gaa cag gag cct caa aag aag aac     4263
 Ser Arg Ala Gln Thr Ile Gln Arg Glu Gln Glu Pro Gln Lys Lys Asn
    1340                1345                1350

 agg act gac cca aac atc tct cca gac cag agt tct ggc ttc act aca     4311
 Arg Thr Asp Pro Asn Ile Ser Pro Asp Gln Ser Ser Gly Phe Thr Thr
1355                1360                1365                1370

 ccc act gct atg aca cct cct gtt cta acc aca gcc gaa act tca gtc     4359
 Pro Thr Ala Met Thr Pro Pro Val Leu Thr Thr Ala Glu Thr Ser Val
                1375                1380                1385

 aag ccc agt gtc tct gca ttc act cat tcc cca cca gaa aac aca act     4407
 Lys Pro Ser Val Ser Ala Phe Thr His Ser Pro Pro Glu Asn Thr Thr
            1390                1395                1400

 ggg att tca agc aca atc agt ttt cat tca aga act ctt aat ctg aca     4455
 Gly Ile Ser Ser Thr Ile Ser Phe His Ser Arg Thr Leu Asn Leu Thr
        1405                1410                1415

 gat gtg att gaa gaa cta gcc caa gca agt act cag act ttg aag agc     4503
 Asp Val Ile Glu Glu Leu Ala Gln Ala Ser Thr Gln Thr Leu Lys Ser
    1420                1425                1430

 aca att gct tct gaa aca act ttg tcc agc aaa tca cac cag agt acc     4551
 Thr Ile Ala Ser Glu Thr Thr Leu Ser Ser Lys Ser His Gln Ser Thr
1435                1440                1445                1450

 aca act agg aaa gca atc att aga cac tca acc ata cca cca ttc ttg     4599
 Thr Thr Arg Lys Ala Ile Ile Arg His Ser Thr Ile Pro Pro Phe Leu
                1455                1460                1465

 agc agc agt gct act cta atg cca gtt ccc atc tcc cct ccc ttt act     4647
 Ser Ser Ser Ala Thr Leu Met Pro Val Pro Ile Ser Pro Pro Phe Thr
            1470                1475                1480

 cag aga gca gtt act gac aac gtg gcg act ccc att tcc ggg ctt atg     4695
 Gln Arg Ala Val Thr Asp Asn Val Ala Thr Pro Ile Ser Gly Leu Met
        1485                1490                1495

 aca aat aca gtg gtc aag ctg cac gaa tcc tca agg cac aat gct aaa     4743
 Thr Asn Thr Val Val Lys Leu His Glu Ser Ser Arg His Asn Ala Lys
    1500                1505                1510

 cca cag caa tta gta gca gag gtt gca aca tcc ccc aag gtt cac cca     4791
 Pro Gln Gln Leu Val Ala Glu Val Ala Thr Ser Pro Lys Val His Pro
1515                1520                1525                1530

 aat gcc aag ttc aca att gga acc act cac ttc atc tac tct aat ctg     4839
 Asn Ala Lys Phe Thr Ile Gly Thr Thr His Phe Ile Tyr Ser Asn Leu
                1535                1540                1545

 tta cat tct act ccc atg cca gca cta aca aca gtt aaa tca cag aat     4887
 Leu His Ser Thr Pro Met Pro Ala Leu Thr Thr Val Lys Ser Gln Asn
            1550                1555                1560

 tct aaa tta act cca tct ccc tgg gca gaa aac caa ttt tgg cac aaa     4935
 Ser Lys Leu Thr Pro Ser Pro Trp Ala Glu Asn Gln Phe Trp His Lys
        1565                1570                1575

 cca tac tca gaa att gct gaa aaa ggc aaa aag cca gaa gta agc atg     4983
 Pro Tyr Ser Glu Ile Ala Glu Lys Gly Lys Lys Pro Glu Val Ser Met
    1580                1585                1590

 ttg gct act aca ggc ctg tcc gag gcc acc act ctt gtt tca gat tgg     5031
 Leu Ala Thr Thr Gly Leu Ser Glu Ala Thr Thr Leu Val Ser Asp Trp
1595                1600                1605                1610

 gat gga cag aag aac aca aag aag agt gac ttt gat aag aaa cca gtt     5079
 Asp Gly Gln Lys Asn Thr Lys Lys Ser Asp Phe Asp Lys Lys Pro Val
                1615                1620                1625

 caa gaa gca aca act tcc aaa ctc ctt ccc ttt gac tct ttg tct agg     5127
 Gln Glu Ala Thr Thr Ser Lys Leu Leu Pro Phe Asp Ser Leu Ser Arg
            1630                1635                1640

 tat ata ttt gaa aag ccc agg ata gtt gga gga aaa gct gca agt ttt     5175
 Tyr Ile Phe Glu Lys Pro Arg Ile Val Gly Gly Lys Ala Ala Ser Phe
        1645                1650                1655

 act att cca gct aac tca gat gcc ttt ctt ccc tgt gaa gct gtt gga     5223
 Thr Ile Pro Ala Asn Ser Asp Ala Phe Leu Pro Cys Glu Ala Val Gly
    1660                1665                1670

 aat ccc ctg ccc acc att cat tgg acc aga gtc cca tca gga ctt gat     5271
 Asn Pro Leu Pro Thr Ile His Trp Thr Arg Val Pro Ser Gly Leu Asp
1675                1680                1685                1690

 tta tct aag agg aaa cag aat agc agg gtc cag gtt ctc ccc aat ggt     5319
 Leu Ser Lys Arg Lys Gln Asn Ser Arg Val Gln Val Leu Pro Asn Gly
                1695                1700                1705

 acc ctg tcc atc cag agg gtg gaa att cag gac cgc gga cag tac ttg     5367
 Thr Leu Ser Ile Gln Arg Val Glu Ile Gln Asp Arg Gly Gln Tyr Leu
            1710                1715                1720

 tgt tcc gca tcc aat ctg ttt ggc aca gac cac ctt cat gtc acc ttg     5415
 Cys Ser Ala Ser Asn Leu Phe Gly Thr Asp His Leu His Val Thr Leu
        1725                1730                1735

 tct gtg gtt tcc tat cct ccc agg atc ctg gag aga cgt acc aaa gag     5463
 Ser Val Val Ser Tyr Pro Pro Arg Ile Leu Glu Arg Arg Thr Lys Glu
    1740                1745                1750

 atc aca gtt cat tcc gga agc act gtg gaa ctg aag tgc aga gca gaa     5511
 Ile Thr Val His Ser Gly Ser Thr Val Glu Leu Lys Cys Arg Ala Glu
1755                1760                1765                1770

 ggt agg cca agc cct aca gtt acc tgg att ctt gca aac caa aca gtt     5559
 Gly Arg Pro Ser Pro Thr Val Thr Trp Ile Leu Ala Asn Gln Thr Val
                1775                1780                1785

 gtc tca gaa tca tcc cag gga agt agg cag gct gtg gtg acg gtt gac     5607
 Val Ser Glu Ser Ser Gln Gly Ser Arg Gln Ala Val Val Thr Val Asp
            1790                1795                1800

 gga aca ttg gtc ctc cac aat ctc agt att tat gac cgt ggc ttt tac     5655
 Gly Thr Leu Val Leu His Asn Leu Ser Ile Tyr Asp Arg Gly Phe Tyr
        1805                1810                1815

 aaa tgt gtg gcc agc aac cca ggt ggc cag gat tca ctg ctg gtt aaa     5703
 Lys Cys Val Ala Ser Asn Pro Gly Gly Gln Asp Ser Leu Leu Val Lys
    1820                1825                1830

 ata caa gtc att gca gca cca cct gtt att cta gag caa agg agg caa     5751
 Ile Gln Val Ile Ala Ala Pro Pro Val Ile Leu Glu Gln Arg Arg Gln
1835                1840                1845                1850

 gtc att gta ggc act tgg ggt gaa agt tta aaa ctg ccc tgt act gca     5799
 Val Ile Val Gly Thr Trp Gly Glu Ser Leu Lys Leu Pro Cys Thr Ala
                1855                1860                1865

 aaa gga act cct cag ccc agc gtt tac tgg gtc ctc tct gat ggc act     5847
 Lys Gly Thr Pro Gln Pro Ser Val Tyr Trp Val Leu Ser Asp Gly Thr
            1870                1875                1880

 gaa gtg aaa cca tta cag ttt acc aat tcc aag ttg ttc tta ttt tca     5895
 Glu Val Lys Pro Leu Gln Phe Thr Asn Ser Lys Leu Phe Leu Phe Ser
        1885                1890                1895

 aat ggg act ttg tat ata aga aac cta gcc tct tca gac agg ggc act     5943
 Asn Gly Thr Leu Tyr Ile Arg Asn Leu Ala Ser Ser Asp Arg Gly Thr
    1900                1905                1910

 tat gaa tgc att gct acc agt tcc act ggt tcg gag cga aga gta gta     5991
 Tyr Glu Cys Ile Ala Thr Ser Ser Thr Gly Ser Glu Arg Arg Val Val
1915                1920                1925                1930

 atg ctt aca atg gaa gag cga gtg acc agc ccc agg ata gaa gct gca     6039
 Met Leu Thr Met Glu Glu Arg Val Thr Ser Pro Arg Ile Glu Ala Ala
                1935                1940                1945

 tcc cag aaa agg act gaa gtg aat ttt ggg gac aaa tta cta ctg aac     6087
 Ser Gln Lys Arg Thr Glu Val Asn Phe Gly Asp Lys Leu Leu Leu Asn
            1950                1955                1960

 tgc tca gcc act ggg gag ccc aaa ccc caa ata atg tgg agg tta cca     6135
 Cys Ser Ala Thr Gly Glu Pro Lys Pro Gln Ile Met Trp Arg Leu Pro
        1965                1970                1975

 tcc aag gct gtg gtc gac cag cag cat aga gtg ggc agc tgg atc cac     6183
 Ser Lys Ala Val Val Asp Gln Gln His Arg Val Gly Ser Trp Ile His
    1980                1985                1990

 gtc tac cct aat gga tcc ctg ttt att gga tca gta aca gaa aaa gac     6231
 Val Tyr Pro Asn Gly Ser Leu Phe Ile Gly Ser Val Thr Glu Lys Asp
1995                2000                2005                2010

 agt ggt gtc tac ttg tgt gtg gca aga aac aaa atg ggg gat gat ctg     6279
 Ser Gly Val Tyr Leu Cys Val Ala Arg Asn Lys Met Gly Asp Asp Leu
                2015                2020                2025

 ata ctg atg cat gtt agc cta aga ctg aaa cct gcc aaa att gac cac     6327
 Ile Leu Met His Val Ser Leu Arg Leu Lys Pro Ala Lys Ile Asp His
            2030                2035                2040

 aag cag tat ttt aga aag caa gtg ctc cat ggg aaa gat ttc caa gta     6375
 Lys Gln Tyr Phe Arg Lys Gln Val Leu His Gly Lys Asp Phe Gln Val
        2045                2050                2055

 gat tgc aaa gct tcc ggc tcc cca gtg cca gag ata tct tgg agt ttg     6423
 Asp Cys Lys Ala Ser Gly Ser Pro Val Pro Glu Ile Ser Trp Ser Leu
    2060                2065                2070

 cct gat gga acc atg atc aac aat gca atg caa gcc gat gac agt ggc     6471
 Pro Asp Gly Thr Met Ile Asn Asn Ala Met Gln Ala Asp Asp Ser Gly
2075                2080                2085                2090

 cac agg act agg aga tat acc ctt ttc aac aat gga act tta tac ttc     6519
 His Arg Thr Arg Arg Tyr Thr Leu Phe Asn Asn Gly Thr Leu Tyr Phe
                2095                2100                2105

 aac aaa gtt ggg gta gcg gag gaa gga gat tat act tgc tat gcc cag     6567
 Asn Lys Val Gly Val Ala Glu Glu Gly Asp Tyr Thr Cys Tyr Ala Gln
            2110                2115                2120

 aac acc cta ggg aaa gat gaa atg aag gtc cac tta aca gtt ata aca     6615
 Asn Thr Leu Gly Lys Asp Glu Met Lys Val His Leu Thr Val Ile Thr
        2125                2130                2135

 gct gct ccc cgg ata agg cag agt aac aaa acc aac aag aga atc aaa     6663
 Ala Ala Pro Arg Ile Arg Gln Ser Asn Lys Thr Asn Lys Arg Ile Lys
    2140                2145                2150

 gct gga gac aca gct gtc ctt gac tgt gag gtc act ggg gat ccc aaa     6711
 Ala Gly Asp Thr Ala Val Leu Asp Cys Glu Val Thr Gly Asp Pro Lys
2155                2160                2165                2170

 cca aaa ata ttt tgg ttg ctg cct tcc aat gac atg att tcc ttc tcc     6759
 Pro Lys Ile Phe Trp Leu Leu Pro Ser Asn Asp Met Ile Ser Phe Ser
                2175                2180                2185

 att gat agg tac aca ttt cat gcc aat ggg tct ttg acc atc aac aaa     6807
 Ile Asp Arg Tyr Thr Phe His Ala Asn Gly Ser Leu Thr Ile Asn Lys
            2190                2195                2200

 gtg aaa ctg ctc gat tct gga gag tac gta tgt gta gcc cga aat ccc     6855
 Val Lys Leu Leu Asp Ser Gly Glu Tyr Val Cys Val Ala Arg Asn Pro
        2205                2210                2215

 agt ggg gat gac acc aaa atg tac aaa ctg gat gtg gtc tct aaa cct     6903
 Ser Gly Asp Asp Thr Lys Met Tyr Lys Leu Asp Val Val Ser Lys Pro
    2220                2225                2230

 cca tta atc aat ggt ctg tat aca aac aga act gtt att aaa gcc aca     6951
 Pro Leu Ile Asn Gly Leu Tyr Thr Asn Arg Thr Val Ile Lys Ala Thr
2235                2240                2245                2250

 gct gtg aga cat tcc aaa aaa cac ttt gac tgc aga gct gaa ggg aca     6999
 Ala Val Arg His Ser Lys Lys His Phe Asp Cys Arg Ala Glu Gly Thr
                2255                2260                2265

 cca tct cct gaa gtc atg tgg atc atg cca gac aat att ttc ctc aca     7047
 Pro Ser Pro Glu Val Met Trp Ile Met Pro Asp Asn Ile Phe Leu Thr
            2270                2275                2280

 gcc cca tac tat gga agc aga atc aca gtc cat aaa aat gga acc ttg     7095
 Ala Pro Tyr Tyr Gly Ser Arg Ile Thr Val His Lys Asn Gly Thr Leu
        2285                2290                2295

 gaa att agg aat gtg agg ctt tca gat tca gcc gac ttt atc tgt gtg     7143
 Glu Ile Arg Asn Val Arg Leu Ser Asp Ser Ala Asp Phe Ile Cys Val
    2300                2305                2310

 gcc cga aat gaa ggt gga gag agc gtg ttg gta gta cag tta gaa gta     7191
 Ala Arg Asn Glu Gly Gly Glu Ser Val Leu Val Val Gln Leu Glu Val
2315                2320                2325                2330

 ctg gaa atg ctg aga aga ccg aca ttt aga aat cca ttt aat gaa aaa     7239
 Leu Glu Met Leu Arg Arg Pro Thr Phe Arg Asn Pro Phe Asn Glu Lys
                2335                2340                2345

 ata gtt gcc cag ctg gga aag tcc aca gca ttg aat tgc tct gtt gat     7287
 Ile Val Ala Gln Leu Gly Lys Ser Thr Ala Leu Asn Cys Ser Val Asp
            2350                2355                2360

 ggt aac cca cca cct gaa ata atc tgg att tta cca aat ggc aca cga     7335
 Gly Asn Pro Pro Pro Glu Ile Ile Trp Ile Leu Pro Asn Gly Thr Arg
        2365                2370                2375

 ttt tcc aat gga cca caa agt tat cag tat ctg ata gca agc aat ggt     7383
 Phe Ser Asn Gly Pro Gln Ser Tyr Gln Tyr Leu Ile Ala Ser Asn Gly
    2380                2385                2390

 tct ttt atc att tct aaa aca act cgg gag gat gca gga aaa tat cgc     7431
 Ser Phe Ile Ile Ser Lys Thr Thr Arg Glu Asp Ala Gly Lys Tyr Arg
2395                2400                2405                2410

 tgt gca gct agg aat aaa gtt ggc tat att gag aaa tta gtc ata tta     7479
 Cys Ala Ala Arg Asn Lys Val Gly Tyr Ile Glu Lys Leu Val Ile Leu
                2415                2420                2425

 gaa att ggc cag aag cca gtt att ctt acc tat gca cca ggg aca gta     7527
 Glu Ile Gly Gln Lys Pro Val Ile Leu Thr Tyr Ala Pro Gly Thr Val
            2430                2435                2440

 aaa ggc atc agt gga gaa tct cta tca ctg cat tgt gtg tct gat gga     7575
 Lys Gly Ile Ser Gly Glu Ser Leu Ser Leu His Cys Val Ser Asp Gly
        2445                2450                2455

 atc cct aag cca aat atc aaa tgg act atg cca agt ggt tat gta gta     7623
 Ile Pro Lys Pro Asn Ile Lys Trp Thr Met Pro Ser Gly Tyr Val Val
    2460                2465                2470

 gac agg cct caa att aat ggg aaa tac ata ttg cat gac aat ggc acc     7671
 Asp Arg Pro Gln Ile Asn Gly Lys Tyr Ile Leu His Asp Asn Gly Thr
2475                2480                2485                2490

 tta gtc att aaa gaa gca aca gct tat gac aga gga aac tat atc tgt     7719
 Leu Val Ile Lys Glu Ala Thr Ala Tyr Asp Arg Gly Asn Tyr Ile Cys
                2495                2500                2505

 aag gct caa aat agt gtt ggt cat aca ctg att act gtt cca gta atg     7767
 Lys Ala Gln Asn Ser Val Gly His Thr Leu Ile Thr Val Pro Val Met
            2510                2515                2520

 att gta gcc tac cct ccc cga att aca aat cgt cca ccc agg agt att     7815
 Ile Val Ala Tyr Pro Pro Arg Ile Thr Asn Arg Pro Pro Arg Ser Ile
        2525                2530                2535

 gtc acc agg aca ggg gca gcc ttt cag ctc cac tgt gtg gcc ttg gga     7863
 Val Thr Arg Thr Gly Ala Ala Phe Gln Leu His Cys Val Ala Leu Gly
    2540                2545                2550

 gtt ccc aag cca gaa atc acg tgg gag atg cct gac cac tcc ctt ctc     7911
 Val Pro Lys Pro Glu Ile Thr Trp Glu Met Pro Asp His Ser Leu Leu
2555                2560                2565                2570

 tca acg gca agt aaa gag agg aca cat gga agt gag cag ctt cac tta     7959
 Ser Thr Ala Ser Lys Glu Arg Thr His Gly Ser Glu Gln Leu His Leu
                2575                2580                2585

 caa ggt acc cta gtc att cag aat ccc caa acc tcc gat tct ggg ata     8007
 Gln Gly Thr Leu Val Ile Gln Asn Pro Gln Thr Ser Asp Ser Gly Ile
            2590                2595                2600

 tac aaa tgc aca gca aag aac cca ctt ggt agt gat tat gca gca acg     8055
 Tyr Lys Cys Thr Ala Lys Asn Pro Leu Gly Ser Asp Tyr Ala Ala Thr
        2605                2610                2615

 tat att caa gta atc tga catgaa ataataaagt caacaacatc tgggcagaat     8109
 Tyr Ile Gln Val Ile 
    2620

 ttattttttg gaagaagttt aatcaaaggc agccataggc atgtaaatga atttgaatac   8169

 atttacagta ttaaatttac aatgaacatg caaaataaaa ggacttgtaa ataaatgcat   8229

 tatgaactga tgatactgat ttatttaatg gatctcaaaa caaactttta acttaaggca   8289

 cttttatttt gccaacaaat aacaataaac aaacattgaa acggttcact ataaaataac   8349

 aaatggctaa tgtacctgaa tttttcagta aaaaaatgaa cttctaatac cagttgccta   8409

 gtgtccacct cctatcaatg ttacaagcat ggcactcaga acagagacaa tggaaaatat   8469

 taaatctgca atctttatga tgtaaattta ccatcctgat gtataaatat tttgtggttt   8529

 ataaattttt ttgctaaaac ctacagaaaa taagcactga actgtcttat gattcaccat   8589

 ttgttcacac tgaaaatttt cattgatggg gaatacaaaa atgttttaat aactgcattt   8649

 aaaaataaat gcaggctcac ttttccacat gtaaaaagca atgtaatacc tgcacatcat   8709

 aaaatgtgaa aagggggtta tttttgtcca aatacaccca ttaaaaaggt tttaaaaata   8769

 aaaaaaaaaa aaa                                                      8782




      <210> 131
      <211> 2640
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2142)..(2618)

      <400> 131
 acttgtcatg gcgactgtcc agctttgtgc caggagcctc gcaggggttg atgggattgg     60

 ggttttcccc tcccatgtgc tcaagactgg cgctaaaagt tttgagcttc tcaaaagtct    120

 agagccaccg tccagggagc aggtagctgc tgggctccgg ggacactttg cgttcgggct    180

 gggagcgtgc tttccacgac ggtgacacgc ttccctggat tggcagccag actgccttcc    240

 gggtcactgc catggaggag ccgcagtcag atcctagcgt cgagccccct ctgagtcagg    300

 aaacattttc agacctatgg aaactacttc ctgaaaacaa cgttctgtcc cccttgccgt    360

 cccaagcaat ggatgatttg atgctgtccc cggacgatat tgaacaatgg ttcactgaag    420

 acccaggtcc agatgaagct cccagaatgc cagaggctgc tccccgcgtg gcccctgcac    480

 cagcagctcc tacaccggcg gcccctgcac cagccccctc ctggcccctg tcatcttctg    540

 tcccttccca gaaaacctac cagggcagct acggtttccg tctgggcttc ttgcattctg    600

 ggacagccaa gtctgtgact tgcacgtact cccctgccct caacaagatg ttttgccaac    660

 tggccaagac ctgccctgtg cagctgtggg ttgattccac acccccgccc ggcacccgcg    720

 tccgcgccat ggccatctac aagcagtcac agcacatgac ggaggttgtg aggcgctgcc    780

 cccaccatga gcgctgctca gatagcgatg gtctggcccc tcctcagcat cttatccgag    840

 tggaaggaaa tttgcgtgtg gagtatttgg atgacagaaa cacttttcga catagtgtgg    900

 tggtgcccta tgagccgcct gaggttggct ctgactgtac caccatccac tacaactaca    960

 tgtgtaacag ttcctgcatg ggcggcatga accggaggcc catcctcacc atcatcacac   1020

 tggaagactc cagtggtaat ctactgggac ggaacagctt tgaggtgcgt gtttgtgcct   1080

 gtcctgggag agaccggcgc acagaggaag agaatctccg caagaaaggg gagcctcacc   1140

 acgagctgcc cccagggagc actaagcgag cactgcccaa caacaccagc tcctctcccc   1200

 agccaaagaa gaaaccactg gatggagaat atttcaccct tcagatccgt gggcgtgagc   1260

 gcttcgagat gttccgagag ctgaatgagg ccttggaact caaggatgcc caggctggga   1320

 aggagccagg ggggagcagg gctcactcca gccacctgaa gtccaaaaag ggtcagtcta   1380

 cctcccgcca taaaaaactc atgttcaaga cagaagggcc tgactcagac tgacattctc   1440

 cacttcttgt tccccactga cagcctccca cccccatctc tccctcccct gccattttgg   1500

 gttttgggtc tttgaaccct tgcttgcaat aggtgtgcgt cagaagcacc caggacttcc   1560

 atttgctttg tcccggggct ccactgaaca agttggcctg cactggtgtt ttgttgtggg   1620

 gaggaggatg gggagtagga cataccagct tagattttaa ggtttttact gtgagggatg   1680

 tttgggagat gtaagaaatg ttcttgcagt taagggttag tttacaatca gccacattct   1740

 aggtaggtag gggcccactt caccgtacta accagggaag ctgtccctca ctgttgaatt   1800

 ttctctaact tcaaggccca tatctgtgaa atgctggcat ttgcacctac ctcacagagt   1860

 gcattgtgag ggttaatgaa ataatgtaca tctggccttg aaaccacctt ttattacatg   1920

 gggtctagaa cttgaccccc ttgagggtgc ttgttccctc tccctctccc tgttggctgg   1980

 tgggttggta gtttctacag ttgggcagct ggttaggtag agggagttgt caagtctctg   2040

 ctggcccagc caaaccctgt ctgacaacct cttggtgaac cttagtacct aaaaggaaat   2100

 ctcaccccat cccacaccct ggaggatttc atctcttgta t    atg atg atc tgg    2153
                                                  Met Met Ile Trp
                                                    1

 atc cac caa gac ttg ttt tat gct cag ggt caa ttt ctt ttt tct ttt     2201
 Ile His Gln Asp Leu Phe Tyr Ala Gln Gly Gln Phe Leu Phe Ser Phe
   5                  10                  15                  20

 ttt ttt ttt ttt ttc ttt ttc ttt gag act ggg tct cgc ttt gtt gcc     2249
 Phe Phe Phe Phe Phe Phe Phe Phe Glu Thr Gly Ser Arg Phe Val Ala
                  25                  30                  35

 cag gct gga gtg gag tgg cgt gat ctt ggc tta ctg cag cct ttg cct     2297
 Gln Ala Gly Val Glu Trp Arg Asp Leu Gly Leu Leu Gln Pro Leu Pro
              40                  45                  50

 ccc cgg ctc gag cag tcc tgc ctc agc ctc cgg agt agc tgg gac cac     2345
 Pro Arg Leu Glu Gln Ser Cys Leu Ser Leu Arg Ser Ser Trp Asp His
          55                  60                  65

 agg ttc atg cca cca tgg cca gcc aac ttt tgc atg ttt tgt aga gat     2393
 Arg Phe Met Pro Pro Trp Pro Ala Asn Phe Cys Met Phe Cys Arg Asp
      70                  75                  80

 ggg gtc tca cag tgt tgc cca ggc tgg tct caa act cct ggg ctc agg     2441
 Gly Val Ser Gln Cys Cys Pro Gly Trp Ser Gln Thr Pro Gly Leu Arg
  85                  90                  95                 100

 cga tcc acc tgt ctc agc ctc cca gag tgc tgg gat tac aat tgt gag     2489
 Arg Ser Thr Cys Leu Ser Leu Pro Glu Cys Trp Asp Tyr Asn Cys Glu
                 105                 110                 115

 cca cca cgt cca gct gga agg gtc aac atc ttt tac att ctg caa gca     2537
 Pro Pro Arg Pro Ala Gly Arg Val Asn Ile Phe Tyr Ile Leu Gln Ala
             120                 125                 130

 cat ctg cat ttt cac ccc acc ctt ccc ctc ctt ctc cct ttt tat atc     2585
 His Leu His Phe His Pro Thr Leu Pro Leu Leu Leu Pro Phe Tyr Ile
         135                 140                 145

 cca ttt tta tat cga tct ctt att tta caa taa aactttgc tgccaaaaaa     2636
 Pro Phe Leu Tyr Arg Ser Leu Ile Leu Gln 
     150                 155

 aaaa                                                                2640




      <210> 132
      <211> 1885
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (14)..(1114)

      <400> 132
 agcagagcag ata   atg gca agc atg gct gcc gtg ctc acc tgg gct ctg      49
                  Met Ala Ser Met Ala Ala Val Leu Thr Trp Ala Leu
                    1               5                  10

 gct ctt ctt tca gcg ttt tcg gcc acc cag gca cgg aaa ggc ttc tgg       97
 Ala Leu Leu Ser Ala Phe Ser Ala Thr Gln Ala Arg Lys Gly Phe Trp
          15                  20                  25

 gac tac ttc agc cag acc agc ggg gac aaa ggc agg gtg gag cag atc      145
 Asp Tyr Phe Ser Gln Thr Ser Gly Asp Lys Gly Arg Val Glu Gln Ile
      30                  35                  40

 cat cag cag aag atg gct cgc gag ccc gcg acc ctg aaa gac agc ctt      193
 His Gln Gln Lys Met Ala Arg Glu Pro Ala Thr Leu Lys Asp Ser Leu
  45                  50                  55                  60

 gag caa gac ctc aac aat atg aac aag ttc ctg gaa aag ctg agg cct      241
 Glu Gln Asp Leu Asn Asn Met Asn Lys Phe Leu Glu Lys Leu Arg Pro
                  65                  70                  75

 ctg agt ggg agc gag gct cct cgg ctc cca cag gac ccg gtg ggc atg      289
 Leu Ser Gly Ser Glu Ala Pro Arg Leu Pro Gln Asp Pro Val Gly Met
              80                  85                  90

 cgg cgg cag ctg cag gag gag ttg gag gag gtg aag gct cgc ctc cag      337
 Arg Arg Gln Leu Gln Glu Glu Leu Glu Glu Val Lys Ala Arg Leu Gln
          95                 100                 105

 ccc tac atg gca gag gcg cac gag ctg gtg ggc tgg aat ttg gag ggc      385
 Pro Tyr Met Ala Glu Ala His Glu Leu Val Gly Trp Asn Leu Glu Gly
     110                 115                 120

 ttg cgg cag caa ctg aag ccc tac acg atg gat ctg atg gag cag gtg      433
 Leu Arg Gln Gln Leu Lys Pro Tyr Thr Met Asp Leu Met Glu Gln Val
 125                 130                 135                 140

 gcc ctg cgc gtg cag gag ctg cag gag cag ttg cgc gtg gtg ggg gaa      481
 Ala Leu Arg Val Gln Glu Leu Gln Glu Gln Leu Arg Val Val Gly Glu
                 145                 150                 155

 gac acc aag gcc cag ttg ctg ggg ggc gtg gac gag gct tgg gct ttg      529
 Asp Thr Lys Ala Gln Leu Leu Gly Gly Val Asp Glu Ala Trp Ala Leu
             160                 165                 170

 ctg cag gga ctg cag agc cgc gtg gtg cac cac acc ggc cgc ttc aaa      577
 Leu Gln Gly Leu Gln Ser Arg Val Val His His Thr Gly Arg Phe Lys
         175                 180                 185

 gag ctc ttc cac cca tac gcc gag agc ctg gtg agc ggc atc ggg cgc      625
 Glu Leu Phe His Pro Tyr Ala Glu Ser Leu Val Ser Gly Ile Gly Arg
     190                 195                 200

 cac gtg cag gag ctg cac cgc agt gtg gct ccg cac gcc ccc gcc agc      673
 His Val Gln Glu Leu His Arg Ser Val Ala Pro His Ala Pro Ala Ser
 205                 210                 215                 220

 ccc gcg cgc ctc agt cgc tgc gtg cag gtg ctc tcc cgg aag ctc acg      721
 Pro Ala Arg Leu Ser Arg Cys Val Gln Val Leu Ser Arg Lys Leu Thr
                 225                 230                 235

 ctc aag gcc aag gcc ctg cac gca cgc atc cag cag aac ctg gac cag      769
 Leu Lys Ala Lys Ala Leu His Ala Arg Ile Gln Gln Asn Leu Asp Gln
             240                 245                 250

 ctg cgc gaa gag ctc agc aga gcc ttt gca ggc act ggg act gag gaa      817
 Leu Arg Glu Glu Leu Ser Arg Ala Phe Ala Gly Thr Gly Thr Glu Glu
         255                 260                 265

 ggg gcc ggc ccg gac ccc cag atg ctc tcc gag gag gtg cgc cag cga      865
 Gly Ala Gly Pro Asp Pro Gln Met Leu Ser Glu Glu Val Arg Gln Arg
     270                 275                 280

 ctt cag gct ttc cgc cag gac acc tac ctg cag ata gct gcc ttc act      913
 Leu Gln Ala Phe Arg Gln Asp Thr Tyr Leu Gln Ile Ala Ala Phe Thr
 285                 290                 295                 300

 cgc gcc atc gac cag gag act gag gag gtc cag cag cag ctg gcg cca      961
 Arg Ala Ile Asp Gln Glu Thr Glu Glu Val Gln Gln Gln Leu Ala Pro
                 305                 310                 315

 cct cca cca ggc cac agt gcc ttc gcc cca gag ttt caa caa aca gac     1009
 Pro Pro Pro Gly His Ser Ala Phe Ala Pro Glu Phe Gln Gln Thr Asp
             320                 325                 330

 agt ggc aag gtt ctg agc aag ctg cag gcc cgt ctg gat gac ctg tgg     1057
 Ser Gly Lys Val Leu Ser Lys Leu Gln Ala Arg Leu Asp Asp Leu Trp
         335                 340                 345

 gaa gac atc act cac agc ctt cat gac cag ggc cac agc cat ctg ggg     1105
 Glu Asp Ile Thr His Ser Leu His Asp Gln Gly His Ser His Leu Gly
     350                 355                 360

 gac ccc tga ggatcta cctgcccagg cccattccca gctccttgtc tggggagcct     1161
 Asp Pro 
 365

 tggctctgag cctctagcat ggttcagtcc ttgaaagtgg cctgttgggt ggagggtgga   1221

 aggtcctgtg caggacaggg aggccaccaa aggggctgct gtctcctgca tatccagcct   1281

 cctgcgactc cccaatctgg atgcattaca ttcaccaggc tttgcaaacc cagcctccca   1341

 gtgctcattt gggaatgctc atgagttact ccattcaagg gtgagggagt agggagggag   1401

 aggcaccatg catgtgggtg attatctgca agcctgtttg ccgtgatgct ggaagcctgt   1461

 gccactacat cctggagttt ggctctagtc acttctggct gcctggtggc cactgctaca   1521

 gctggtccac agagaggagc acttgtctcc ccagggctgc catggcagct atcaggggaa   1581

 tagaagggag aaagagaata tcatggggag aacatgtgat ggtgtgtgaa tatccctgct   1641

 ggctctgatg ctggtgggta cgaaaggtgt gggctgtgat aggagagggc agagcccatg   1701

 tttcctgaca tagctctaca cctaaataag ggactgaacc ctcccaactg cgggagctcc   1761

 ttaaaccctc tggggagcat actgtgtgct ctccccatct ccagcccctc cctctgggtt   1821

 cccaagttga agcctagact tctggctcaa atgaaataga tgtttatgat agaaaaaaaa   1881

 aaaa                                                                1885




      <210> 133
      <211> 1858
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(1146)

      <220>
      <221> misc_feature
      <222> (1)...(1858)
      <223> n = a,t,c or g

      <400> 133
 cccacgcgtc cgggcctccc tccacctgtc ttctcagagc agata    atg gca agc      54
                                                      Met Ala Ser
                                                        1

 atg gct gcc gtg ctc acc tgg gct ctg gct ctt ctt tca gcg ttt tcg      102
 Met Ala Ala Val Leu Thr Trp Ala Leu Ala Leu Leu Ser Ala Phe Ser
       5                  10                  15

 gcc acc cag gca cgg aaa ggc ttc tgg gac tac ttc agc cag acc agc      150
 Ala Thr Gln Ala Arg Lys Gly Phe Trp Asp Tyr Phe Ser Gln Thr Ser
  20                  25                  30                  35

 ggg gac aaa ggc agg gtg gag cag atc cat cag cag aag atg gct cgc      198
 Gly Asp Lys Gly Arg Val Glu Gln Ile His Gln Gln Lys Met Ala Arg
                  40                  45                  50

 gag ccc gcg acc ctg aaa gac agc ctt gag caa gac ctc aac aat atg      246
 Glu Pro Ala Thr Leu Lys Asp Ser Leu Glu Gln Asp Leu Asn Asn Met
              55                  60                  65

 aac aag ttc ctg gaa aag ctg agg cct ctg agt ggg agc gag gct cct      294
 Asn Lys Phe Leu Glu Lys Leu Arg Pro Leu Ser Gly Ser Glu Ala Pro
          70                  75                  80

 cgg ctc cca cag gac ccg gtg ggc atg cgg cgg cag ctg cag gag gag      342
 Arg Leu Pro Gln Asp Pro Val Gly Met Arg Arg Gln Leu Gln Glu Glu
      85                  90                  95

 ttg gag gag gtg aag gct cgc ctc cag ccc tac atg gca gag gcg cac      390
 Leu Glu Glu Val Lys Ala Arg Leu Gln Pro Tyr Met Ala Glu Ala His
 100                 105                 110                 115

 gag ctg gtg ggc tgg aat ttg gag ggc ttg cgg cag caa ctg aag ccc      438
 Glu Leu Val Gly Trp Asn Leu Glu Gly Leu Arg Gln Gln Leu Lys Pro
                 120                 125                 130

 tac acg atg gat ctg atg gag cag gtg gcc ctg cgc gtg cag gag ctg      486
 Tyr Thr Met Asp Leu Met Glu Gln Val Ala Leu Arg Val Gln Glu Leu
             135                 140                 145

 cag gag cag ttg cgc gtg gtg ggg gaa gac acc aag gcc cag ttg ctg      534
 Gln Glu Gln Leu Arg Val Val Gly Glu Asp Thr Lys Ala Gln Leu Leu
         150                 155                 160

 ggg ggc gtg gac gag gct tgg gct ttg ctg cag gga ctg cag agc cgc      582
 Gly Gly Val Asp Glu Ala Trp Ala Leu Leu Gln Gly Leu Gln Ser Arg
     165                 170                 175

 gtg gtg cac cac acc ggc cgc ttc aaa gag ctc ttc cac cca tac gcc      630
 Val Val His His Thr Gly Arg Phe Lys Glu Leu Phe His Pro Tyr Ala
 180                 185                 190                 195

 gag agc ctg gtg agc ggc atc ggg cgc cac gtg cag gag ctg cac cgc      678
 Glu Ser Leu Val Ser Gly Ile Gly Arg His Val Gln Glu Leu His Arg
                 200                 205                 210

 agt gtg gct ccg cac gcc ccc gcc agc ccc gcg cgc ctc agt cgc tgc      726
 Ser Val Ala Pro His Ala Pro Ala Ser Pro Ala Arg Leu Ser Arg Cys
             215                 220                 225

 gtg cag gtg ctc tcc cgg aag ctc acg ctc aag gcc aag gcc ctg cac      774
 Val Gln Val Leu Ser Arg Lys Leu Thr Leu Lys Ala Lys Ala Leu His
         230                 235                 240

 gca cgc atc cag cag aac ctg gac cag ctg cgc gaa gag ctc agc aga      822
 Ala Arg Ile Gln Gln Asn Leu Asp Gln Leu Arg Glu Glu Leu Ser Arg
     245                 250                 255

 gcc ttt gca ggc act ggg act gag gaa ggg gcc ggc ccg gac ccc cag      870
 Ala Phe Ala Gly Thr Gly Thr Glu Glu Gly Ala Gly Pro Asp Pro Gln
 260                 265                 270                 275

 atg ctc tcc gag gag gtg cgc cag cga ctt cag gct ttc cgc cag gac      918
 Met Leu Ser Glu Glu Val Arg Gln Arg Leu Gln Ala Phe Arg Gln Asp
                 280                 285                 290

 acc tac ctg cag ata gct gcc ttc act cgc gcc atc gac cag gag act      966
 Thr Tyr Leu Gln Ile Ala Ala Phe Thr Arg Ala Ile Asp Gln Glu Thr
             295                 300                 305

 gag gag gtc cag cag cag ctg gcg cca cct cca cca ggc cac agt gcc     1014
 Glu Glu Val Gln Gln Gln Leu Ala Pro Pro Pro Pro Gly His Ser Ala
         310                 315                 320

 ttc gcc cca gag ttt caa caa aca gac agt ggc aag gtt ctg agc aag     1062
 Phe Ala Pro Glu Phe Gln Gln Thr Asp Ser Gly Lys Val Leu Ser Lys
     325                 330                 335

 ctg cag gcc cgt ctg gat gac ctg tgg gaa gac atc act cac agc ctt     1110
 Leu Gln Ala Arg Leu Asp Asp Leu Trp Glu Asp Ile Thr His Ser Leu
 340                 345                 350                 355

 cat gac cag ggc cac agc cat ctg ggg gac ccc tga ggat ctacctgccc     1160
 His Asp Gln Gly His Ser His Leu Gly Asp Pro 
                 360                 365

 aggcccattc ccagctcctt gtctggggag ccttggctct gagcctctag catggttcag   1220

 tccttgaaag tggcctgttg ggtggagggt ggaaggtcct gtgcaggaca gggaggccac   1280

 caaaggggct gctgtctcct gcatatccag cctcctgcga ctccccaatc tggatgcatt   1340

 acattcacca ggctttgcaa acccagcctc ccagtgctca tttgggaatg ctcatgagtt   1400

 actccattca agggtgaggg agtagggagg gagaggcacc atgcatgtgg gtgattatct   1460

 gcaagcctgt ttgccgtgat gctggaagcc tgtgccacta catcctggag tttggctcta   1520

 gtcacttctg gctgcctggt ggccactgct acagctggtc cacagagagg agcacttgtc   1580

 tccccagggc tgccatggca gctatcaggg gaatagaagg gagaaagaga atatcatggg   1640

 gagaacatgt gatggtgtgt gaatatccct gctggctctg atgctggtgg gtacgaaagg   1700

 tgtgggctgg gataagagag ggcagagccc atgttttctg acataactct acacctanat   1760

 aagggactga acccttccaa ctgcgggagc tccttaaacc cttctgggga gcatactggg   1820

 ggctcttccc catcttcagc cccttcctct gggttccc                           1858




      <210> 134
      <211> 1457
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (138)..(1133)

      <400> 134
 attgtactgg agcttatcgg atttcacctg tagatgtaaa tagtagacct tcctcctgcc     60

 ttactaattt tcttctaaat ggtcgttctg ttttattgga acaaccacga aagtcaggtt    120

 ctaaagtcat tagtcat   atg ctt agt agc cat gga gga gag att ttt ttg     170
                      Met Leu Ser Ser His Gly Gly Glu Ile Phe Leu
                        1               5                  10

 cac gtc ctt agc agt tct cga tcc att cta gaa gat cca cct tca att      218
 His Val Leu Ser Ser Ser Arg Ser Ile Leu Glu Asp Pro Pro Ser Ile
              15                  20                  25

 agt gaa gga tgt gga gga aga gtt aca gac tac cgg att aca gat ttt      266
 Ser Glu Gly Cys Gly Gly Arg Val Thr Asp Tyr Arg Ile Thr Asp Phe
          30                  35                  40

 ggt gaa ttt atg agg gaa aac aga tta act cct ttt cta gac ccc aga      314
 Gly Glu Phe Met Arg Glu Asn Arg Leu Thr Pro Phe Leu Asp Pro Arg
      45                  50                  55

 tat aaa atc gat gga agt ctt gag gtc cct ttg gaa cga gca aaa gat      362
 Tyr Lys Ile Asp Gly Ser Leu Glu Val Pro Leu Glu Arg Ala Lys Asp
  60                  65                  70                  75

 cag tta gaa aaa cat acc cgt tac tgg cct atg atc att tca caa acc      410
 Gln Leu Glu Lys His Thr Arg Tyr Trp Pro Met Ile Ile Ser Gln Thr
                  80                  85                  90

 acc att ttt aac atg caa gcg gta gtt cca tta gcc agt gtt att gtg      458
 Thr Ile Phe Asn Met Gln Ala Val Val Pro Leu Ala Ser Val Ile Val
              95                 100                 105

 aaa gaa tct ctg aca gaa gaa gat gtg tta aac tgt caa aaa aca ata      506
 Lys Glu Ser Leu Thr Glu Glu Asp Val Leu Asn Cys Gln Lys Thr Ile
         110                 115                 120

 tac aac tta gtt gat atg gaa aga aaa aat gat cct cta cct att tcc      554
 Tyr Asn Leu Val Asp Met Glu Arg Lys Asn Asp Pro Leu Pro Ile Ser
     125                 130                 135

 aca gtt ggt aca aga gga aag ggc cct aaa aga gat gaa caa tac cgt      602
 Thr Val Gly Thr Arg Gly Lys Gly Pro Lys Arg Asp Glu Gln Tyr Arg
 140                 145                 150                 155

 atc atg tgg aat gaa tta gaa acc ctt gtc aga gcc cat atc aac aac      650
 Ile Met Trp Asn Glu Leu Glu Thr Leu Val Arg Ala His Ile Asn Asn
                 160                 165                 170

 tca gag aaa cat caa aga gtc ttg gaa tgt ctg atg gca tgc agg agc      698
 Ser Glu Lys His Gln Arg Val Leu Glu Cys Leu Met Ala Cys Arg Ser
             175                 180                 185

 aaa ccc cca gaa gag gaa gaa cga aag aaa cga gga aga aag agg gaa      746
 Lys Pro Pro Glu Glu Glu Glu Arg Lys Lys Arg Gly Arg Lys Arg Glu
         190                 195                 200

 gac aaa gag gac aag tca gag aaa gca gtg aaa gat tat gaa cag gaa      794
 Asp Lys Glu Asp Lys Ser Glu Lys Ala Val Lys Asp Tyr Glu Gln Glu
     205                 210                 215

 aag tct tgg caa gac tca gag aga tta aaa gga atc tta gaa cgt gga      842
 Lys Ser Trp Gln Asp Ser Glu Arg Leu Lys Gly Ile Leu Glu Arg Gly
 220                 225                 230                 235

 aaa gaa gaa ttg gct gaa gct gag att ata aaa gat tcg cct gat tcc      890
 Lys Glu Glu Leu Ala Glu Ala Glu Ile Ile Lys Asp Ser Pro Asp Ser
                 240                 245                 250

 cca gaa cct cca aac aaa aaa ccc ctt gtt gaa atg gat gaa act cca      938
 Pro Glu Pro Pro Asn Lys Lys Pro Leu Val Glu Met Asp Glu Thr Pro
             255                 260                 265

 caa gtg gaa aaa tca aaa ggg cca gtg tcg tta tta tcc ttg tgg agt      986
 Gln Val Glu Lys Ser Lys Gly Pro Val Ser Leu Leu Ser Leu Trp Ser
         270                 275                 280

 aat aga atc aat act gcc aat tcc aga aaa cat cag gaa ttt gct gga     1034
 Asn Arg Ile Asn Thr Ala Asn Ser Arg Lys His Gln Glu Phe Ala Gly
     285                 290                 295

 cgt ttg aac tct gtt aat aac aga gct gaa cta tat caa cat ctt aaa     1082
 Arg Leu Asn Ser Val Asn Asn Arg Ala Glu Leu Tyr Gln His Leu Lys
 300                 305                 310                 315

 gag gaa aat ggg atg gag aca aca gaa aat gga aaa gcc agc cgg cag     1130
 Glu Glu Asn Gly Met Glu Thr Thr Glu Asn Gly Lys Ala Ser Arg Gln
                 320                 325                 330

 tga agag tgacttgaag aactaaattt agcatattgc aaaaatattt tgtgcggaat     1187
 


 tcgatataag tacttttaca gcaagatggt atagttatgt tgcctggact ggtttttaca   1247

 tttttaaaat atttcagctg tcatttttgt actaattata aaattggcac ataattcaaa   1307

 aatatacatt tgagatgatt tgtcctccca aattatacaa gtttatttta tggtataaag   1367

 tgttctctct ggaaatgttt ttaaaaaaat tcttaggctt ctctttgcga aataaaacta   1427

 ttaaaatatt tgaaatgcaa aaaaaaaaaa                                    1457




      <210> 135
      <211> 1931
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (18)..(455)

      <400> 135
 gaagcttctc gaggacc   atg gaa ctt gca ctg ctg tgt ggg ctg gtg gtg      50
                      Met Glu Leu Ala Leu Leu Cys Gly Leu Val Val
                        1               5                  10

 atg gct ggt gtg att cca atc cag ggc ggg atc ctg aac ctg aac aag       98
 Met Ala Gly Val Ile Pro Ile Gln Gly Gly Ile Leu Asn Leu Asn Lys
              15                  20                  25

 atg gtc aag caa gtg act ggg aaa atg ccc atc ctc tcc tac tgg ccc      146
 Met Val Lys Gln Val Thr Gly Lys Met Pro Ile Leu Ser Tyr Trp Pro
          30                  35                  40

 tac ggc tgt cac tgc gga cta ggt ggc aga ggc caa ccc aaa gat gcc      194
 Tyr Gly Cys His Cys Gly Leu Gly Gly Arg Gly Gln Pro Lys Asp Ala
      45                  50                  55

 acg gac tgg tgc tgc cag acc cat gac tgc tgc tat gac cac ctg aag      242
 Thr Asp Trp Cys Cys Gln Thr His Asp Cys Cys Tyr Asp His Leu Lys
  60                  65                  70                  75

 acc cag ggg tgc ggc atc tac aag gac tat tac aga tac aac ttt tcc      290
 Thr Gln Gly Cys Gly Ile Tyr Lys Asp Tyr Tyr Arg Tyr Asn Phe Ser
                  80                  85                  90

 cag ggg aac atc cac tgc tct gac aag gga agc tgg tgt gag cag cag      338
 Gln Gly Asn Ile His Cys Ser Asp Lys Gly Ser Trp Cys Glu Gln Gln
              95                 100                 105

 ctg tgt gcc tgt gac aag gag gtg gcc ttc tgc ctg aag cgc aac ctg      386
 Leu Cys Ala Cys Asp Lys Glu Val Ala Phe Cys Leu Lys Arg Asn Leu
         110                 115                 120

 gac acc tac cag aag cga ctg cgt ttc tac tgg cgg ccc cac tgc cgg      434
 Asp Thr Tyr Gln Lys Arg Leu Arg Phe Tyr Trp Arg Pro His Cys Arg
     125                 130                 135

 ggg cag acc cct ggg tgc tag aa gcccacaccc tctaccctgt tcctcagcat      487
 Gly Gln Thr Pro Gly Cys 
 140                 145

 ggagctctgg catccccacc tcagtatcta acctgaacca gcctggcttt tcaaacactc    547

 cggggggagg tagtcccagc ctcccccgga accctctacc aatgccttct gaccttctga    607

 agctttccga atcctcccag ttgaggcagt agctgtgtcc tctgagggtg gatgggaatc    667

 ttgggagaag cccaagcaag ggagccctca gaggtggtgt ttggaccaaa gcatcggggt    727

 gggggagggg tctgccgctg tcccccacct gctggccccc ttgtccttcc tcaccccctc    787

 caatatagtc tcggagctac aaccgcagca gccactataa agggcaatat tgatctttct    847

 gtccatgtgg ctctatcttt taaaacctca aggccctcca ctgtcctaag ataaagcctc    907

 tcataggcac tggggaccct gcacagtctg gccatgtgac cctctcccca ggcaagctct    967

 gaagtccctg caggtggagg ccatgcctgt cttaaactca gttgcatccc tggtgcccaa   1027

 agcaacacca gaaccaagaa ggagctccat aaatccttct tgggtgaagc ctagacaaag   1087

 ccgccaggtc ttgtggctcc aggcaccaga gccttgagta ctttctcctg cctccaggca   1147

 ttggctcagg gtgaattaca aggggctact gaatggctat tactttcatc acgactgatc   1207

 cccacctcct cagggtcaaa gggctacttt ctggaagtct ccccaggctg actccttctc   1267

 cctgactgca agggctcact ccctcctcca agctcccaca atgcttcatg gctctgccgc   1327

 ttacctagct tggcctagag tggcaaatgg aacttctctg atctccccca actagactgg   1387

 agcccccgaa ggatggagac catgtctgtg ccatctctgt ttcccctgtt ttcccacata   1447

 ctaggtgctc aattcatgcc tgtgaatggc gtgagcccat aatggataca cagaggttgc   1507

 agcagatggt gtgggtacct cacccagata tcttccaggc ccaaggcccc tctccctgag   1567

 tgaggccagg tgttggcagc caactgctcc aatctgcctc cttcccctaa atactgccct   1627

 ggtctagtgg gagctgcctt ccccctgccc cacctctccc accaagaggc cacctgtcac   1687

 tcatggccag gagagtgaca ccatggaggg tacaattgcc agctcccccg tgtctgtgca   1747

 gcattgtctg ggttgaatga cactctcaaa ttgttcctgg gatcgggctg aggccaggcc   1807

 tctcctggaa ccacctctct gcttggtctg accccttggc ctatccagtt ttcctggttc   1867

 cctcacaggt ttctccagaa agtactccct cagtaaagca tttgcacaag aaaaaaaaaa   1927

 aaaa                                                                1931




      <210> 136
      <211> 821
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(545)

      <400> 136
 tccagcacca ggaagagtgg ctctaggagg gagaggagcc cagggactga cccaag         56                                                                 
 atg ccg ttg act cca gag ccg ccc tct ggg cgc gtg gag ggg ccc ccc      104
 Met Pro Leu Thr Pro Glu Pro Pro Ser Gly Arg Val Glu Gly Pro Pro
   1               5                  10                  15

 gca tgg gaa gca gcc cca tgg ccc tca ctg ccc tgt ggg ccc tgc atc      152
 Ala Trp Glu Ala Ala Pro Trp Pro Ser Leu Pro Cys Gly Pro Cys Ile
              20                  25                  30

 ccc atc atg ctg gtc ctg gcc acc ctg gct gcg ctc ttc atc ctc acc      200
 Pro Ile Met Leu Val Leu Ala Thr Leu Ala Ala Leu Phe Ile Leu Thr
          35                  40                  45

 acc gct gtg ttg gct gaa cgc ctg ttc cgc cgt gct ctc cgc cca gac      248
 Thr Ala Val Leu Ala Glu Arg Leu Phe Arg Arg Ala Leu Arg Pro Asp
      50                  55                  60

 ccc agc cac cgt gca ccc acc ctg gtg tgg cgc cca gga gga gag ctg      296
 Pro Ser His Arg Ala Pro Thr Leu Val Trp Arg Pro Gly Gly Glu Leu
  65                  70                  75                  80

 tgg att gag ccc atg ggc acc gcc cga gag cgc tct gag gac tgg tat      344
 Trp Ile Glu Pro Met Gly Thr Ala Arg Glu Arg Ser Glu Asp Trp Tyr
                  85                  90                  95

 ggc tct gcg gtc ccc ctg ctg aca gat cgg gcc cct gag cct ccc acc      392
 Gly Ser Ala Val Pro Leu Leu Thr Asp Arg Ala Pro Glu Pro Pro Thr
             100                 105                 110

 cag gtg ggc act ttg gag gcc cga gca aca gcc ccc aca ctg agc cac      440
 Gln Val Gly Thr Leu Glu Ala Arg Ala Thr Ala Pro Thr Leu Ser His
         115                 120                 125

 tca gaa ccc aaa gta ctg cat ccc agc aga ctt ggg acc ccg cag acc      488
 Ser Glu Pro Lys Val Leu His Pro Ser Arg Leu Gly Thr Pro Gln Thr
     130                 135                 140

 gat act gga ggt ccc aag cac acg gag aca cct atc tgg ggg ccc aca      536
 Asp Thr Gly Gly Pro Lys His Thr Glu Thr Pro Ile Trp Gly Pro Thr
 145                 150                 155                 160

 gaa cca tga ggagggc gagagcacca caccgacagc agagccatgg tgagactggg      592
 Glu Pro 


 cttgaaccac agagacaaaa gagccaacag agcccaaaag gtcagataag aggagcaccc    652

 acaaggccaa aggacggaaa cacagagcac gcggacgccc aggaatccat gaacatggcg    712

 agccaaccac accaaaagcg tccaaccaca gcgaccagga atcgacagac aaaacacgag    772

 aaagcgtaga agggccggaa caaggagatg gagaatcaga aaacccaag                821




      <210> 137
      <211> 2020
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (182)..(1390)

      <400> 137
 gcctgcgtta gatgcccctg aattaccggg tcgacccacg cgtccgggat cccgaccagt     60

 cctgaccgca cgggggccgc ggccacgggg cgcaggggcc atggtgcgcg gcaggatctc    120

 ccggctctcg gtccgggacg tgcgcttccc cacgtcgctt gggggccacg gcgcggacgc    180

 c    atg cac acg gac cct gac tac tcg gct gcc tat gtc gtc ata gaa     226
      Met His Thr Asp Pro Asp Tyr Ser Ala Ala Tyr Val Val Ile Glu
        1               5                  10                  15

 act gat gca gaa gat gga atc aag ggg tgt gga att acc ttc act ctg      274
 Thr Asp Ala Glu Asp Gly Ile Lys Gly Cys Gly Ile Thr Phe Thr Leu
                  20                  25                  30

 gga aaa ggc act gaa gtt gtt gtc tgt gct gtg aat gcc ctc gcc cac      322
 Gly Lys Gly Thr Glu Val Val Val Cys Ala Val Asn Ala Leu Ala His
              35                  40                  45

 cat gtg ctc aac aag gac ctc aag gac att gtt ggt gac ttc aga ggc      370
 His Val Leu Asn Lys Asp Leu Lys Asp Ile Val Gly Asp Phe Arg Gly
          50                  55                  60

 ttc tat agg cag ctc aca agt gat ggg cag ctc aga tgg att ggt cca      418
 Phe Tyr Arg Gln Leu Thr Ser Asp Gly Gln Leu Arg Trp Ile Gly Pro
      65                  70                  75

 gaa aag ggc gtg gtg cac ctg gcg aca gcg gcc gtc cta aac gcg gtg      466
 Glu Lys Gly Val Val His Leu Ala Thr Ala Ala Val Leu Asn Ala Val
  80                  85                  90                  95

 tgg gac ttg tgg gcc aag cag gag gga aag cct gtc tgg aag tta ctt      514
 Trp Asp Leu Trp Ala Lys Gln Glu Gly Lys Pro Val Trp Lys Leu Leu
                 100                 105                 110

 gtg gac atg gat ccc agg atg ctg gta tcc tgc ata gat ttc agg tac      562
 Val Asp Met Asp Pro Arg Met Leu Val Ser Cys Ile Asp Phe Arg Tyr
             115                 120                 125

 atc act gat gtc ctg act gag gag gat gcc cta gaa ata ctg cag aaa      610
 Ile Thr Asp Val Leu Thr Glu Glu Asp Ala Leu Glu Ile Leu Gln Lys
         130                 135                 140

 ggt caa att ggt aaa aaa gaa aga gag aag caa atg ctg gca caa gga      658
 Gly Gln Ile Gly Lys Lys Glu Arg Glu Lys Gln Met Leu Ala Gln Gly
     145                 150                 155

 tac cct gct tac acg aca tcg tgc gcc tgg ctg ggg tac tca gat gac      706
 Tyr Pro Ala Tyr Thr Thr Ser Cys Ala Trp Leu Gly Tyr Ser Asp Asp
 160                 165                 170                 175

 acg ttg aag cag ctc tgt gcc cag gcg ctg aag gat ggc tgg acc agg      754
 Thr Leu Lys Gln Leu Cys Ala Gln Ala Leu Lys Asp Gly Trp Thr Arg
                 180                 185                 190

 ttt aaa gta aag gtg ggt gct gat ctc cag gat gac atg cga aga tgc      802
 Phe Lys Val Lys Val Gly Ala Asp Leu Gln Asp Asp Met Arg Arg Cys
             195                 200                 205

 caa atc atc cga gac atg att gga ccg gaa aag act ttg atg atg gat      850
 Gln Ile Ile Arg Asp Met Ile Gly Pro Glu Lys Thr Leu Met Met Asp
         210                 215                 220

 gcc aac cag cgc tgg gat gtg cct gag gcg gtg gag tgg atg tcc aag      898
 Ala Asn Gln Arg Trp Asp Val Pro Glu Ala Val Glu Trp Met Ser Lys
     225                 230                 235

 ctg gcc aag ttc aag cca ttg tgg att gag gag cca acc tcc cct gat      946
 Leu Ala Lys Phe Lys Pro Leu Trp Ile Glu Glu Pro Thr Ser Pro Asp
 240                 245                 250                 255

 gac att ctg ggg cac gcc acc att tcc aag tgc cac aat aga gtg ata      994
 Asp Ile Leu Gly His Ala Thr Ile Ser Lys Cys His Asn Arg Val Ile
                 260                 265                 270

 ttt aag caa ctc cta cag gcg aag gcc ctg cag ttc ctc cag att gac     1042
 Phe Lys Gln Leu Leu Gln Ala Lys Ala Leu Gln Phe Leu Gln Ile Asp
             275                 280                 285

 agt tgc aga ctg ggc agt gtc aat gag aac ctc tca gta ttg ctg atg     1090
 Ser Cys Arg Leu Gly Ser Val Asn Glu Asn Leu Ser Val Leu Leu Met
         290                 295                 300

 gcc aaa aag ttt gaa att cct gtt tgc ccc cat gct ggt gga gtt ggc     1138
 Ala Lys Lys Phe Glu Ile Pro Val Cys Pro His Ala Gly Gly Val Gly
     305                 310                 315

 ctc tgt gaa ctg gtg cag cac ctg att ata ttt gac tac ata tca gtt     1186
 Leu Cys Glu Leu Val Gln His Leu Ile Ile Phe Asp Tyr Ile Ser Val
 320                 325                 330                 335

 tct gca agc ctt gaa aat agg gtg tgt gag tat gtt gac cac ctg cat     1234
 Ser Ala Ser Leu Glu Asn Arg Val Cys Glu Tyr Val Asp His Leu His
                 340                 345                 350

 gag cat ttc aag tat ccc gtg atg atc cag cgg gct tcc tac atg cct     1282
 Glu His Phe Lys Tyr Pro Val Met Ile Gln Arg Ala Ser Tyr Met Pro
             355                 360                 365

 ccc aag gat ccc ggc tac tca aca gaa atg aag gag gaa tct gta aag     1330
 Pro Lys Asp Pro Gly Tyr Ser Thr Glu Met Lys Glu Glu Ser Val Lys
         370                 375                 380

 aaa cac cag tat cca gat ggt gaa gtt tgg aag aaa ctc ctt cct gct     1378
 Lys His Gln Tyr Pro Asp Gly Glu Val Trp Lys Lys Leu Leu Pro Ala
     385                 390                 395

 caa gaa aat taa gtg ctcagcccca acaacttttt tctttctgaa gtgaaagggc     1433
 Gln Glu Asn 
 400

 ttaaaatttc ttggaaatag ttttacaaaa atggatttaa aaaatcctac cgatcaagat   1493

 gagttcagct agaagtcata ccaccctcag gaatcagcta agtaattatt acttgattct   1553

 tttagcaaat caatgcacgt tatcctactt aatccttaaa taagtttaga tttaactaac   1613

 ccaaagtcca ggaggatgtt cttacaaaaa tagctatatc aagggctggc acctagacat   1673

 taaactgtaa tttgaaaata agcaacatgt tgcataactt gttggaataa ttccttgttc   1733

 tgtttaacac ttgtcataaa ttagcagaat aaaaatagtc gtgcaacacc gggggtatct   1793

 ggtatgcaac gaagggaaaa atatttcact gattaacccc gaagtggttt tgcatctttt   1853

 ccttgcttaa tctaagcata ttattagaga agtcacacca tgctgaagct aatgagggca   1913

 aaatggtagt ccatagatta ttttaaaata accctttaag gttataaaag tttaaaaaaa   1973

 aaaaaaaaaa attctgcggt ccaagcttat tccctttagt gaggtta                 2020




      <210> 138
      <211> 1293
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (133)..(1119)

      <400> 138
 agcgccatct gctcgcggcg ccgcctcctg ctcctcccgc tgctgctgcc gctgccgccc     60

 tgagtcactg cctgcgcagc tccggccgcc tggctcccca tactagtcgc cgatatttgg    120

 agttcttaca ac    atg gca gac att gac aac ctg cct agg gta gtt aaa     168
                  Met Ala Asp Ile Asp Asn Leu Pro Arg Val Val Lys
                    1               5                  10

 aga cga gtg aat gct ctc aaa aac ctg caa gtt aaa tgt gca cag ata      216
 Arg Arg Val Asn Ala Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile
          15                  20                  25

 gaa gcc aaa ttc tat gag gaa gtt cac gat ctt gaa agg aag tat gct      264
 Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala
      30                  35                  40

 gtt ctc tat cag cct cta ttt gat aag cga ttt gaa att att aat gca      312
 Val Leu Tyr Gln Pro Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala
  45                  50                  55                  60

 att tat gaa cct acg gaa gaa gaa tgt gaa tgg aaa cca gat gaa gaa      360
 Ile Tyr Glu Pro Thr Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu
                  65                  70                  75

 gat gag att tcg gag gaa ttg aaa gaa aag gcc aag att gaa gat gag      408
 Asp Glu Ile Ser Glu Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu
              80                  85                  90

 aaa aag gat gaa gaa aaa gaa gac ccc aaa gga att cct gaa ttt tgg      456
 Lys Lys Asp Glu Glu Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp
          95                 100                 105

 tta act gtt ttt aag aat gtt gac ttg ctc agt gat atg gtt cag gaa      504
 Leu Thr Val Phe Lys Asn Val Asp Leu Leu Ser Asp Met Val Gln Glu
     110                 115                 120

 cac gat gaa cct att ctg aag cac ttg aaa gat att aaa gtg aag ttc      552
 His Asp Glu Pro Ile Leu Lys His Leu Lys Asp Ile Lys Val Lys Phe
 125                 130                 135                 140

 tca gat gct ggc cag cct atg agt ttt gtc tta gaa ttt cac ttt gaa      600
 Ser Asp Ala Gly Gln Pro Met Ser Phe Val Leu Glu Phe His Phe Glu
                 145                 150                 155

 ccc aat gaa tat ttt aca aat gaa gtg ctg aca aag aca tac agg atg      648
 Pro Asn Glu Tyr Phe Thr Asn Glu Val Leu Thr Lys Thr Tyr Arg Met
             160                 165                 170

 agg tca gaa cca gat gat tct gat ccc ttt tct ttt gat gga cca gaa      696
 Arg Ser Glu Pro Asp Asp Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu
         175                 180                 185

 att atg ggt tgt aca ggg tgc cag ata gat tgg aaa aaa gga aag aat      744
 Ile Met Gly Cys Thr Gly Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn
     190                 195                 200

 gtc act ttg aaa act att aag aag aag cag aaa cac aag gga cgt ggg      792
 Val Thr Leu Lys Thr Ile Lys Lys Lys Gln Lys His Lys Gly Arg Gly
 205                 210                 215                 220

 aca gtt cgt act gtg act aaa aca gtt tcc aat gac tct ttc ttt aac      840
 Thr Val Arg Thr Val Thr Lys Thr Val Ser Asn Asp Ser Phe Phe Asn
                 225                 230                 235

 ttt ttt gcc cct cct gaa gtt cct gag agt gga gat ctg gat gat gat      888
 Phe Phe Ala Pro Pro Glu Val Pro Glu Ser Gly Asp Leu Asp Asp Asp
             240                 245                 250

 gct gaa gct atc ctt gct gca gac ttc gaa att ggt cac ttt tta cgt      936
 Ala Glu Ala Ile Leu Ala Ala Asp Phe Glu Ile Gly His Phe Leu Arg
         255                 260                 265

 gag cgt ata atc cca aga tca gtg tta tat ttt act gga gaa gct att      984
 Glu Arg Ile Ile Pro Arg Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile
     270                 275                 280

 gaa gat gat gat gat gat tat gat gaa gaa ggt gaa gaa gcg gat gag     1032
 Glu Asp Asp Asp Asp Asp Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu
 285                 290                 295                 300

 gaa ggg gaa gaa gaa gga gat gag gaa aat gat cca gac tat gac cca     1080
 Glu Gly Glu Glu Glu Gly Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro
                 305                 310                 315

 aag aag gat caa aac cca gca gag tgc aag cag cag tga agcaggatgt      1129
 Lys Lys Asp Gln Asn Pro Ala Glu Cys Lys Gln Gln 
             320                 325

 atgtggcctt gaggataacc tgcactggtc taccttctgc ttccctggaa aggatgaatt   1189

 tacatcattt gacaagccta ttttcaagtt atttgttgtt tgtttgcttg tttttgtttt   1249

 tgcagctaaa ataaaaattt caaatacaaa aaaaaaaaaa aaaa                    1293




      <210> 139
      <211> 1411
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(1266)

      <400> 139
 attcccgggt cgacgatttc gtggagcccg gccgctgctc gcgggctgag tgtctgtcgc     60

 tgctgccgcc tccacccagc ctccgcc    atg gac ctc ttc ggg gac ctg ccg     111
                                  Met Asp Leu Phe Gly Asp Leu Pro
                                    1               5

 gag ccc gag cgc tcg ccg cgc ccg gct gcc ggg aaa gaa gct cac aaa      159
 Glu Pro Glu Arg Ser Pro Arg Pro Ala Ala Gly Lys Glu Ala His Lys
      10                  15                  20

 gga ccc ctg ctc ttt gat gac ctc cct ccg gcc agc agt act gac tca      207
 Gly Pro Leu Leu Phe Asp Asp Leu Pro Pro Ala Ser Ser Thr Asp Ser
  25                  30                  35                  40

 gga tca ggg gga cct ttg ctt ttt gat gat ctc cca ccc gct agc agt      255
 Gly Ser Gly Gly Pro Leu Leu Phe Asp Asp Leu Pro Pro Ala Ser Ser
                  45                  50                  55

 ggc gat tca ggt tct ctt gcc aca tca ata tcc cag atg gta aag act      303
 Gly Asp Ser Gly Ser Leu Ala Thr Ser Ile Ser Gln Met Val Lys Thr
              60                  65                  70

 gaa ggg aaa gga gca aag aga aaa acc tcc gag gaa gag aag aat ggc      351
 Glu Gly Lys Gly Ala Lys Arg Lys Thr Ser Glu Glu Glu Lys Asn Gly
          75                  80                  85

 agt gaa gag ctt gtg gaa aag aaa gtt tgt aaa gcc tct tcg gtg atc      399
 Ser Glu Glu Leu Val Glu Lys Lys Val Cys Lys Ala Ser Ser Val Ile
      90                  95                 100

 ttt ggt ctg aag ggc tat gtg gct gag cgg aag ggt gag agg gag gag      447
 Phe Gly Leu Lys Gly Tyr Val Ala Glu Arg Lys Gly Glu Arg Glu Glu
 105                 110                 115                 120

 atg cag gat gcc cac gtc atc ctg aac gac atc acc gag gag tgt agg      495
 Met Gln Asp Ala His Val Ile Leu Asn Asp Ile Thr Glu Glu Cys Arg
                 125                 130                 135

 ccc cca tcg tcc ctc att act cgg gtt tca tat ttt gct gtt ttt gat      543
 Pro Pro Ser Ser Leu Ile Thr Arg Val Ser Tyr Phe Ala Val Phe Asp
             140                 145                 150

 gga cat gga gga att cga gcc tca aaa ttt gct gca cag aat ttg cat      591
 Gly His Gly Gly Ile Arg Ala Ser Lys Phe Ala Ala Gln Asn Leu His
         155                 160                 165

 caa aac tta atc aga aaa ttt cct aaa gga gat gta atc agt gta gag      639
 Gln Asn Leu Ile Arg Lys Phe Pro Lys Gly Asp Val Ile Ser Val Glu
     170                 175                 180

 aaa acc gtg aag aga tgc ctt ttg gac act ttc aag cat act gat gaa      687
 Lys Thr Val Lys Arg Cys Leu Leu Asp Thr Phe Lys His Thr Asp Glu
 185                 190                 195                 200

 gag ttc ctt aaa caa gct tcc agc cag aag cct gcc tgg aaa gat ggg      735
 Glu Phe Leu Lys Gln Ala Ser Ser Gln Lys Pro Ala Trp Lys Asp Gly
                 205                 210                 215

 tcc act gcc acg tgt gtt ctg gct gta gac aac att ctt tat att gcc      783
 Ser Thr Ala Thr Cys Val Leu Ala Val Asp Asn Ile Leu Tyr Ile Ala
             220                 225                 230

 aac ctc gga gat agt cgg gca atc ttg tgt cgt tat aat gag gag agt      831
 Asn Leu Gly Asp Ser Arg Ala Ile Leu Cys Arg Tyr Asn Glu Glu Ser
         235                 240                 245

 caa aaa cat gca gcc tta agc ctc agc aaa gag cat aat cca act cag      879
 Gln Lys His Ala Ala Leu Ser Leu Ser Lys Glu His Asn Pro Thr Gln
     250                 255                 260

 tat gaa gag cgg atg agg ata cag aag gct gga gga aac gtc agg gat      927
 Tyr Glu Glu Arg Met Arg Ile Gln Lys Ala Gly Gly Asn Val Arg Asp
 265                 270                 275                 280

 ggg cgt gtt ttg ggc gtg cta gag gtg tca cgc tcc att ggg gac ggg      975
 Gly Arg Val Leu Gly Val Leu Glu Val Ser Arg Ser Ile Gly Asp Gly
                 285                 290                 295

 cag tac aag cgc tgc ggt gtc acc tct gtg ccc gac atc aga cgc tgc     1023
 Gln Tyr Lys Arg Cys Gly Val Thr Ser Val Pro Asp Ile Arg Arg Cys
             300                 305                 310

 cag ctg acc ccc aat gac agg ttc att ttg ttg gcc tgt gat ggg ctc     1071
 Gln Leu Thr Pro Asn Asp Arg Phe Ile Leu Leu Ala Cys Asp Gly Leu
         315                 320                 325

 ttc aag gtc ttt acc cca gaa gaa gcc gtg aac ttc atc ttg tcc tgt     1119
 Phe Lys Val Phe Thr Pro Glu Glu Ala Val Asn Phe Ile Leu Ser Cys
     330                 335                 340

 ctc gag gat gaa aag atc cag acc cgg gaa ggg aag tcc gca gcc gaa     1167
 Leu Glu Asp Glu Lys Ile Gln Thr Arg Glu Gly Lys Ser Ala Ala Glu
 345                 350                 355                 360

 gcc cgc tac gaa gca gcc tgc aac agg ctg gcc aac aag gcg gtg cag     1215
 Ala Arg Tyr Glu Ala Ala Cys Asn Arg Leu Ala Asn Lys Ala Val Gln
                 365                 370                 375

 cgg ggc tcg gcc gac aac gtc act gtg atg gtg gtg cgg ata ggg cac     1263
 Arg Gly Ser Ala Asp Asn Val Thr Val Met Val Val Arg Ile Gly His
             380                 385                 390

 tga gggg tggcgcgcgg ccaggagcac gcatggtatt gacttaaaag gttcattttg     1320
 


 tgtgtgtgca cattgtgtgt tttgtgtact cctgtgggac tcccatggtt gtaaataaag   1380

 gtttctcttt ttttttccta aaaaaaaaaa a                                  1411




      <210> 140
      <211> 2076
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (454)..(1161)

      <400> 140
 gggccactgt gtgaacacag aaggtgggtt tgtgtgcgag tgtgggccgg gcatgcagct     60

 gtctgccgac cgccacagct gccaagacac tgacgaatgc ctagggactc cctgtcagca    120

 gagatgtaaa aacagcattg gcagctacaa gtgttcctgt cgaactggct tccaccttca    180

 tggcaaccgg cactcctgtg tagatacacc ccaaggattc ctctctgctc acccattttc    240

 ttggctgcct ttgctcccct tgatgtaaac gagtgtcgga ggccattgga gaggcgagtc    300

 tgtcaccatt cctgccacaa caccgtgggc agcttcctat gcacatgccg acctggcttc    360

 aggctccgag ctgaccgcgt gtcctgtgaa gctttcccga aagccgtgct ggccccatct    420

 gccatcctgc aaccccggca acacccgtcc aag atg ctt ctg ttg ctt cct gag     474
                                      Met Leu Leu Leu Leu Pro Glu
                                        1               5

 gcc ggc cgg cct gcc ctg tcc cca gga cat agc cct cct tct ggg gct      522
 Ala Gly Arg Pro Ala Leu Ser Pro Gly His Ser Pro Pro Ser Gly Ala
          10                  15                  20

 cca ggg ccc cca gcc gga gtc agg acc acc cgc ctg cca tct ccc acc      570
 Pro Gly Pro Pro Ala Gly Val Arg Thr Thr Arg Leu Pro Ser Pro Thr
      25                  30                  35

 cca cga cta ccc aca tcc tcc cct tct gcc cct gtg tgg ctg ctg tcc      618
 Pro Arg Leu Pro Thr Ser Ser Pro Ser Ala Pro Val Trp Leu Leu Ser
  40                  45                  50                  55

 acc ctg ctg gcc acc cca gtg cct act gcc tcc ctg ctg ggg aac ctc      666
 Thr Leu Leu Ala Thr Pro Val Pro Thr Ala Ser Leu Leu Gly Asn Leu
                  60                  65                  70

 aga ccc ccc tca ctc ctt cag ggg gag gtg atg ggg acc cct tcc tca      714
 Arg Pro Pro Ser Leu Leu Gln Gly Glu Val Met Gly Thr Pro Ser Ser
              75                  80                  85

 ccc agg ggc cct gag tcc ccc cga ctg gca gca ggg ccc tct ccc tgc      762
 Pro Arg Gly Pro Glu Ser Pro Arg Leu Ala Ala Gly Pro Ser Pro Cys
          90                  95                 100

 tgg cac ctg gga gcc atg cat gaa tca agg agt cgc tgg aca gag cct      810
 Trp His Leu Gly Ala Met His Glu Ser Arg Ser Arg Trp Thr Glu Pro
     105                 110                 115

 ggg tgt tcc cag tgc tgg tgc gag gac ggg aag gtg acc tgt gaa aag      858
 Gly Cys Ser Gln Cys Trp Cys Glu Asp Gly Lys Val Thr Cys Glu Lys
 120                 125                 130                 135

 gtg agg tgt gaa gct gct tgt tcc cac cca att ccc tcc aga gat ggt      906
 Val Arg Cys Glu Ala Ala Cys Ser His Pro Ile Pro Ser Arg Asp Gly
                 140                 145                 150

 ggg tgc tgc cca tcg tgc aca ggc tgt ttt cac agt ggt gtc gtc cga      954
 Gly Cys Cys Pro Ser Cys Thr Gly Cys Phe His Ser Gly Val Val Arg
             155                 160                 165

 gct gaa ggg gat gtg ttt tca cct ccc aat gag aac tgc acc gtc tgt     1002
 Ala Glu Gly Asp Val Phe Ser Pro Pro Asn Glu Asn Cys Thr Val Cys
         170                 175                 180

 gtc tgt ctg gct gga aac gtg tcc tgc atc tct cct gag tgt cct tct     1050
 Val Cys Leu Ala Gly Asn Val Ser Cys Ile Ser Pro Glu Cys Pro Ser
     185                 190                 195

 ggc ccc tgt cag acc ccc ccc aca gac gga ttg ctg tac ttg tgt tcc     1098
 Gly Pro Cys Gln Thr Pro Pro Thr Asp Gly Leu Leu Tyr Leu Cys Ser
 200                 205                 210                 215

 agt gag atg cta ttt cca cgg ccg gtg gta cgc aga cgg ggc tgt gtt     1146
 Ser Glu Met Leu Phe Pro Arg Pro Val Val Arg Arg Arg Gly Cys Val
                 220                 225                 230

 cag tgg ggg tgg tga cgagtgtacc acctgtgttt gccagaatgg ggaggtggag     1201
 Gln Trp Gly Trp 
             235

 tgctccttca tgccctgccc tgagctggcc tgcccccgag aagagtggcg gctgggccct   1261

 gggcagtgtt gcttcacctg ccaggagccc acaccctcga caggctgctc tcttgacgac   1321

 aacggggttg agtttccgat tggacagatc tggtcgcctg gtgacccctg tgagttatgc   1381

 atctgccagg gcggggaggc aggggccggt gtctccggtg gggtcttggt gaagttcctc   1441

 cttcctccag gcagatggct cggtgagctg caagaggaca gactgtgtgg actcctgccc   1501

 tcacccgatc cggatccctg gacagtgctg cccagactgt tcagcaggct gcacctacac   1561

 aggcagaatc ttctataaca acgagacctt cccgtctgtg ctggacccat gtctgagctg   1621

 catctgcctg ctgggctcag cggcctgttc ccccgtggac tgccccatca cctgtaccta   1681

 ccctttccac cctgacgggg agtgctgccc cgtgtgccga gactgcaact acgagggaag   1741

 gaaggtggcg aatggccagg tgttcacctt ggatgatgaa ccctgcaccc ggtgcacgtg   1801

 ccagctggga gaggtgagct gtgagaaggt tccctgccag cgggcctgtg ccgaccctgc   1861

 cctgcttcct ggggactgct gctcttcctg tccagattcc ctgtctcctc tggaagaaaa   1921

 gcaggggctc tcccctcacg gaaatgtggc attcagcaaa gctggtcgga gcctgcatgg   1981

 agacactgag gcccctgtca actgtagctc ctgtcctggg cccccgacag catcaccctc   2041

 gaggccggtg cttcaactcc tccagctgta ttcgc                              2076




      <210> 141
      <211> 1788
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (833)..(1417)

      <400> 141
 atttggccct cgaggccaag aattcggcac gagggatcca aggtcaaaaa aacaaattca     60

 tcaattcagc acaccaccaa ctcacaggct aagcatctta ctgctaattc attgatgctg    120

 ccatttgtca agtgccaaat tgaattattg atttgtcaat aatttccttc cgttggttac    180

 ttatatagta tattgcaatt cttgttgctg aagtcagcta cactttttct atttgaaaaa    240

 caatttcttg catttgggat ttcaggtata gtgattgtta caaatatgaa ggacttgaat    300

 taacagcaag ttttcaagta aaactttact tatgtataac tgaatgagtt cttaaagaca    360

 tttactaaca attttccaca aactaaaaat ttataaaaca ataaataaaa tagactttaa    420

 aaaaaagcgt gtcacacagc tgcttgtttt ttgtttgttt ctttgtttgt tttttagtag    480

 tgaaatggtg aaaaatcaga caatggtcac agagttcctc ctactgggat ttctcctggg    540

 cccaaggatt cagatgctcc tctttgggct cttctccctg ttctatgtct tcaccctgct    600

 ggggaatggg accatcctgg ggctcatctc actggactcc agactccaca cccccatgta    660

 cttcttcctc tcacacctgg ccgtcgtcaa catcgcctat gcctgcaaca cagtgcccca    720

 gatgctggtg aacctcctgc atccagccaa gcccatctcc tttgctggct gcatgacata    780

 gacctttctc tttttgagtt ttgcacatac tgaatgcctc ctgttggtgc tg    atg     835
                                                              Met
                                                                1

 tcc tac gat cgg tac gtg gcc atc tgc cac cct ctc cga tat ttc atc      883
 Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Phe Ile
               5                  10                  15

 atc atg acc tgg aaa gtc tgc atc act ctg gcc atc act tcc tgg aca      931
 Ile Met Thr Trp Lys Val Cys Ile Thr Leu Ala Ile Thr Ser Trp Thr
          20                  25                  30

 tgt ggc tcc ctc ctg gct atg gtc cat gtg agc ctc atc cta aga ctg      979
 Cys Gly Ser Leu Leu Ala Met Val His Val Ser Leu Ile Leu Arg Leu
      35                  40                  45

 ccc ttt tgt ggg cct cgt gaa atc aac cac ttc ttc tgt gaa atc ctg     1027
 Pro Phe Cys Gly Pro Arg Glu Ile Asn His Phe Phe Cys Glu Ile Leu
  50                  55                  60                  65

 tct gtc ctc agg ctg gcc tgt gct gat acc tgg ctc aac cag gtg gtc     1075
 Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp Leu Asn Gln Val Val
                  70                  75                  80

 atc ttt gca gcc tgc atg ttc atc ctg gtg gga cca ctc tgc ctg gtg     1123
 Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly Pro Leu Cys Leu Val
              85                  90                  95

 ctg gtc tcc tac tca cac atc ctg gcg gcc atc ctg agg atc cag tct     1171
 Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile Leu Arg Ile Gln Ser
         100                 105                 110

 ggg gag ggc cgc aga aag gcc ttc tcc acc tgc tcc tcc cac ctc tgc     1219
 Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser His Leu Cys
     115                 120                 125

 gta gtg gga ctc ttc ttt ggc agc gcc atc gtc atg tac atg gcc cct     1267
 Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val Met Tyr Met Ala Pro
 130                 135                 140                 145

 aag tcc cgc cat cct gag gag cag cag aag gtc ctt ttt cta ttt tac     1315
 Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val Leu Phe Leu Phe Tyr
                 150                 155                 160

 agt tct ttc aac ccg atg cta aac ccc ctg att tac aac ctg agg aat     1363
 Ser Ser Phe Asn Pro Met Leu Asn Pro Leu Ile Tyr Asn Leu Arg Asn
             165                 170                 175

 gta gag gtc aag ggt gcc ctg agg aga gca ctg tgc aag gaa agt cat     1411
 Val Glu Val Lys Gly Ala Leu Arg Arg Ala Leu Cys Lys Glu Ser His
         180                 185                 190

 tcc taa gaggtgtgac atttgaactg ccagcctcag ttgtcacgtg gactcttgat      1467
 Ser 


 gcccaattat tgcctcaatc cagaaaagtt tacttctctt tatctgtgct ttactgacag   1527

 aagggcaagt cttctctcgt tttttgcaga taaaatttta gatgtgttgc attcattggg   1587

 tttctatgag atgtggtttt atcagacaat tttttctttt atttcacaat tactttaata   1647

 tctgtaaaat aaagaattat tttaattcat tttcccagtc ccaaaagtta aatacaggcc   1707

 acttacttct ttaaccaaat gatatagttt ggctctgtgt ccccacccaa atctcatgtc   1767

 aaattgtaat ccccgcatgt g                                             1788




      <210> 142
      <211> 1782
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (485)..(1411)

      <400> 142
 atttggccct cgaggccaag aattcggcac gagggatcca aggtcaaaaa aacaaattca     60

 tcaattcagc acaccaccaa ctcacaggct aagcatctta ctgctaattc attgatgctg    120

 ccatttgtca agtgccaaat tgaattattg atttgtcaat aatttccttc cgttggttac    180

 ttatatagta tattgcaatt cttgttgctg aagtcagcta cactttttct atttgaaaaa    240

 caatttcttg catttgggat ttcaggtata gtgattgtta caaatatgaa ggacttgaat    300

 taacagcaag ttttcaagta aaactttact tatgtataac tgaatgagtt cttaaagaca    360

 tttactaaca attttccaca aactaaaaat ttataaaaca ataaataaaa tagactttaa    420

 aaaaaagcgt gtcacacagc tgcttgtttt ttgtttgttt ctttgtttgt tttttagtag    480

 tgaa atg gtg aaa aat cag aca atg gtc aca gag ttc ctc cta ctg gga     529
      Met Val Lys Asn Gln Thr Met Val Thr Glu Phe Leu Leu Leu Gly
        1               5                  10                  15

 ttt ctc ctg ggc cca agg att cag atg ctc ctc ttt ggg ctc ttc tcc      577
 Phe Leu Leu Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser
                  20                  25                  30

 ctg ttc tat atc ttc acc ctg ctg ggg aac ggg gcc atc ctg ggg ctc      625
 Leu Phe Tyr Ile Phe Thr Leu Leu Gly Asn Gly Ala Ile Leu Gly Leu
              35                  40                  45

 atc tca ctg gac tcc aga ctc cat acc ccc atg tac ttc ttc ctc tca      673
 Ile Ser Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser
          50                  55                  60

 cac ctg gct gtc gtc gac atc gcc tac acc cgc aac acg gtg ccc cag      721
 His Leu Ala Val Val Asp Ile Ala Tyr Thr Arg Asn Thr Val Pro Gln
      65                  70                  75

 atg ctg gcg aac ctc ctg cat cca gcc aag ccc atc tcc ttt gct ggt      769
 Met Leu Ala Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly
  80                  85                  90                  95

 tgc atg acg cag acc ttt ctc tgt ttg agt ttt gga cac agc gaa tgt      817
 Cys Met Thr Gln Thr Phe Leu Cys Leu Ser Phe Gly His Ser Glu Cys
                 100                 105                 110

 ctc ctg ctg gtg ctg atg tcc tac gat cgt tac gtg gcc atc tgc cac      865
 Leu Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His
             115                 120                 125

 cct ctc cga tac tcc gtc atc atg acc tgc tgc atc act ctg gcc atc      913
 Pro Leu Arg Tyr Ser Val Ile Met Thr Cys Cys Ile Thr Leu Ala Ile
         130                 135                 140

 act tcc tgg aca tgt ggc tcc ctc ctg gct atg gtc cat gtg agc ctc      961
 Thr Ser Trp Thr Cys Gly Ser Leu Leu Ala Met Val His Val Ser Leu
     145                 150                 155

 atc cta aga ctg ccc ttt tgt ggg cct cgt gaa atc aac cac ttc ttc     1009
 Ile Leu Arg Leu Pro Phe Cys Gly Pro Arg Glu Ile Asn His Phe Phe
 160                 165                 170                 175

 tgt gaa atc ctg tct gtc ctc agg ctg gcc tgt gct gat acc tgg ctc     1057
 Cys Glu Ile Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp Leu
                 180                 185                 190

 aac cag gtg gtc atc ttt gca gcc tgc atg ttc atc ctg gtg gga cca     1105
 Asn Gln Val Val Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly Pro
             195                 200                 205

 ctc tgc ctg gtg ctg gtc tcc tac tca cac atc ctg gcg gcc atc ctg     1153
 Leu Cys Leu Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile Leu
         210                 215                 220

 agg atc cag tct ggg gag ggc cgc aga aag gcc ttc tcc acc tgc tcc     1201
 Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser
     225                 230                 235

 tcc cac ctc tgc gta gtg gga ctc ttc ttt ggc agc gcc atc gtc atg     1249
 Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val Met
 240                 245                 250                 255

 tac atg gcc cct aag tcc cgc cat cct gag gag cag cag aag gtc ctt     1297
 Tyr Met Ala Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val Leu
                 260                 265                 270

 ttt cta ttt tac agt tct ttc aac ccg atg cta aac ccc ctg att tac     1345
 Phe Leu Phe Tyr Ser Ser Phe Asn Pro Met Leu Asn Pro Leu Ile Tyr
             275                 280                 285

 aac ctg agg aat gta gag gtc aag ggt gcc ctg agg aga gca ctg tgc     1393
 Asn Leu Arg Asn Val Glu Val Lys Gly Ala Leu Arg Arg Ala Leu Cys
         290                 295                 300

 aag gaa agt cat tcc taa gaggtg tgacatttga actgccagcc tcagttgtca     1447
 Lys Glu Ser His Ser 
     305

 cgtggactct tgatgcccaa ttattgcctc aatccagaaa agtttacttc tctttatctg   1507

 tgctttactg acagaagggc aagtcttctc tcgttttttg cagataaaat tttagatgtg   1567

 ttgcattcat tgggtttcta tgagatgtgg ttttatcaga caattttttc ttttatttca   1627

 caattacttt aatatctgta aaataaagaa ttattttaat tcattttccc agtcccaaaa   1687

 gttaaataca ggccacttac ttctttaacc aaatgatata gtttggctct gtgtccccac   1747

 ccaaatctca tgtcaaattg taatccccgc atgtg                              1782




      <210> 143
      <211> 395
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(275)

      <220>
      <221> misc_feature
      <222> (1)...(395)
      <223> n = a,t,c or g

      <400> 143
 gtccggattg atcaagagcc    gcc tgt cca gtg tta tgt agg ggc aac ggg      50
                          Ala Cys Pro Val Leu Cys Arg Gly Asn Gly
                            1               5                  10

 cag tac tcc aag ggc cgt tgc ctg tgt ttc agc ggc tgt aag ggc acc       98
 Gln Tyr Ser Lys Gly Arg Cys Leu Cys Phe Ser Gly Cys Lys Gly Thr
                  15                  20                  25

 gag tgt gat gtg ccg act acc cag tgt att gac cca cag tgc ggg gga      146
 Glu Cys Asp Val Pro Thr Thr Gln Cys Ile Asp Pro Gln Cys Gly Gly
              30                  35                  40

 cgt ggg att tgt atc atg ggc tct tgt gct tgc aac tca gga tac aaa      194
 Arg Gly Ile Cys Ile Met Gly Ser Cys Ala Cys Asn Ser Gly Tyr Lys
          45                  50                  55

 gga gaa agt tgt gaa gaa gca cca aga tac att cca gag aag gaa aga      242
 Gly Glu Ser Cys Glu Glu Ala Pro Arg Tyr Ile Pro Glu Lys Glu Arg
      60                  65                  70

 aaa aaa aaa aag gcc tcc aac ttg cat gtt tag gagaaatg gccggacata      293
 Lys Lys Lys Lys Ala Ser Asn Leu His Val 
  75                  80

 gcctaccaaa gtggtggttc ttcgggattt tttggacaag gggggtaact aggaactttt    353

 cttttttact aaaacactga ggttcggggg gtttattttg an                       395




      <210> 144
      <211> 3216
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(2374)

      <400> 144
 ggagaccggc tcggtctctc tctctcccag tggactagaa ggagcagaga gttatgctgt     60

 ttctcccatt ctttacagct caccggatgt aaaagaactc tggctagaga ccctccaagg    120

 acagaggcac agccacacgg gagtgaaatc cacccctgga cagtcagccg caatactg      178                                                                 
 atg aag ctg aga agc agc cac aat gct tca aaa aca cta aac gcc aat      226
 Met Lys Leu Arg Ser Ser His Asn Ala Ser Lys Thr Leu Asn Ala Asn
   1               5                  10                  15

 aat atg gag aca cta atc gaa tgt caa tca gag ggt gat atc aag gaa      274
 Asn Met Glu Thr Leu Ile Glu Cys Gln Ser Glu Gly Asp Ile Lys Glu
              20                  25                  30

 cat ccc ctg ttg gca tca tgt gag agt gaa gac agt att tgc cag ctc      322
 His Pro Leu Leu Ala Ser Cys Glu Ser Glu Asp Ser Ile Cys Gln Leu
          35                  40                  45

 att gaa gtt aag aag aga aag aag gtg ctg tcc tgg ccc ttt ctc atg      370
 Ile Glu Val Lys Lys Arg Lys Lys Val Leu Ser Trp Pro Phe Leu Met
      50                  55                  60

 aga agg ctc tcc cct gca tca gat ttt tct ggg gct ttg gag aca gac      418
 Arg Arg Leu Ser Pro Ala Ser Asp Phe Ser Gly Ala Leu Glu Thr Asp
  65                  70                  75                  80

 ttg aaa gca tcg cta ttt gat cag ccc ttg tca att atc tgc ggt gac      466
 Leu Lys Ala Ser Leu Phe Asp Gln Pro Leu Ser Ile Ile Cys Gly Asp
                  85                  90                  95

 agt gac aca ctc ccc aga ccc atc cag gac att ctc act att cta tgc      514
 Ser Asp Thr Leu Pro Arg Pro Ile Gln Asp Ile Leu Thr Ile Leu Cys
             100                 105                 110

 ctt aaa ggc cct tca acg gaa ggg ata ttc agg aga gca gcc aac gag      562
 Leu Lys Gly Pro Ser Thr Glu Gly Ile Phe Arg Arg Ala Ala Asn Glu
         115                 120                 125

 aaa gcc cgt aag gag ctg aag gag gag ctc aac tct ggg gat gcg gtg      610
 Lys Ala Arg Lys Glu Leu Lys Glu Glu Leu Asn Ser Gly Asp Ala Val
     130                 135                 140

 gat ctg gag agg ctc ccc gtg cac ctc ctc gct gtg gtc ttt aag gac      658
 Asp Leu Glu Arg Leu Pro Val His Leu Leu Ala Val Val Phe Lys Asp
 145                 150                 155                 160

 ttc ctc aga agt atc ccc cgg aag cta ctt tca agc gac ctc ttt gag      706
 Phe Leu Arg Ser Ile Pro Arg Lys Leu Leu Ser Ser Asp Leu Phe Glu
                 165                 170                 175

 gag tgg atg ggt gct ctg gag atg cag gac gag gag gac aga atc gag      754
 Glu Trp Met Gly Ala Leu Glu Met Gln Asp Glu Glu Asp Arg Ile Glu
             180                 185                 190

 gcc ctg aaa cag gtt gca gat aag ctc ccc cgg ccc aac ctc ctg cta      802
 Ala Leu Lys Gln Val Ala Asp Lys Leu Pro Arg Pro Asn Leu Leu Leu
         195                 200                 205

 ctc aag cac ttg gtc tat gtg ctg cac ctc atc agc aag aac tct gag      850
 Leu Lys His Leu Val Tyr Val Leu His Leu Ile Ser Lys Asn Ser Glu
     210                 215                 220

 gtg aac agg atg gac tcc agc aat ctg gcc atc tgc att gga ccc aac      898
 Val Asn Arg Met Asp Ser Ser Asn Leu Ala Ile Cys Ile Gly Pro Asn
 225                 230                 235                 240

 atg ctc acc ctg gag aat gac cag agc ctg tca ttt gaa gcc cag aag      946
 Met Leu Thr Leu Glu Asn Asp Gln Ser Leu Ser Phe Glu Ala Gln Lys
                 245                 250                 255

 gac ctg aac aac aag gtg aag aca ctg gtg gaa ttc ctc att gat aac      994
 Asp Leu Asn Asn Lys Val Lys Thr Leu Val Glu Phe Leu Ile Asp Asn
             260                 265                 270

 tgc ttt gaa ata ttt ggg gag aac att cca gtg cat tcc agt atc act     1042
 Cys Phe Glu Ile Phe Gly Glu Asn Ile Pro Val His Ser Ser Ile Thr
         275                 280                 285

 tct gat gac tcc ctg gag cac act gac agt tca gat gtg tcg acc ctg     1090
 Ser Asp Asp Ser Leu Glu His Thr Asp Ser Ser Asp Val Ser Thr Leu
     290                 295                 300

 cag aat gac tca gcc tac gac agc aac gac cct gat gtg gaa tcc aac     1138
 Gln Asn Asp Ser Ala Tyr Asp Ser Asn Asp Pro Asp Val Glu Ser Asn
 305                 310                 315                 320

 agc agc agt ggc atc agc tct ccc agc agg cag ccc cag gtg ccc atg     1186
 Ser Ser Ser Gly Ile Ser Ser Pro Ser Arg Gln Pro Gln Val Pro Met
                 325                 330                 335

 gcc aca gct gct ggc ttg gat agc gcg ggc cca cag gat gcc cga gag     1234
 Ala Thr Ala Ala Gly Leu Asp Ser Ala Gly Pro Gln Asp Ala Arg Glu
             340                 345                 350

 gtc agc cca gag ccc att gtg agc acc gtg gcc agg ctg aaa agc tcc     1282
 Val Ser Pro Glu Pro Ile Val Ser Thr Val Ala Arg Leu Lys Ser Ser
         355                 360                 365

 ctc gca cag ccc gat agg aga tac tca gag ccc agc atg cca tcc tcc     1330
 Leu Ala Gln Pro Asp Arg Arg Tyr Ser Glu Pro Ser Met Pro Ser Ser
     370                 375                 380

 cag gag tgc ctc gag agc cgg gtg aca aac caa aca cta aca aag agt     1378
 Gln Glu Cys Leu Glu Ser Arg Val Thr Asn Gln Thr Leu Thr Lys Ser
 385                 390                 395                 400

 gaa ggg gac ttc ccc gtg ccc cgg gta ggc tct cgt ttg gaa agt gag     1426
 Glu Gly Asp Phe Pro Val Pro Arg Val Gly Ser Arg Leu Glu Ser Glu
                 405                 410                 415

 gag gct gaa gac cca ttt cca gag gag gtc ttc cct gca gtg caa ggc     1474
 Glu Ala Glu Asp Pro Phe Pro Glu Glu Val Phe Pro Ala Val Gln Gly
             420                 425                 430

 aaa acc aag agg ccg gtg gac ctg aag atc aag aac ttg gcc ccg ggt     1522
 Lys Thr Lys Arg Pro Val Asp Leu Lys Ile Lys Asn Leu Ala Pro Gly
         435                 440                 445

 tcg gtg ctc ccg cgg gca ctg gtt ctc aaa gcc ttc tcc agc agc tcg     1570
 Ser Val Leu Pro Arg Ala Leu Val Leu Lys Ala Phe Ser Ser Ser Ser
     450                 455                 460

 ctg gac gcg tcc tct gac agc tcg ccc gtg gct tct cct tcc agt ccc     1618
 Leu Asp Ala Ser Ser Asp Ser Ser Pro Val Ala Ser Pro Ser Ser Pro
 465                 470                 475                 480

 aaa aga aat ttc ttc agc aga cat cag tct ttc acc aca aag aca gag     1666
 Lys Arg Asn Phe Phe Ser Arg His Gln Ser Phe Thr Thr Lys Thr Glu
                 485                 490                 495

 aaa ggc aag ccc agc cga gaa att aaa aag cac tcc atg tct ttc acc     1714
 Lys Gly Lys Pro Ser Arg Glu Ile Lys Lys His Ser Met Ser Phe Thr
             500                 505                 510

 ttt gcc cct cac aaa aaa gtg ctg acc aaa aac ctc agc gcg ggc tct     1762
 Phe Ala Pro His Lys Lys Val Leu Thr Lys Asn Leu Ser Ala Gly Ser
         515                 520                 525

 ggg aaa tcg caa gac ttt acc agg gac cac gtc ccg agg ggt gtc aga     1810
 Gly Lys Ser Gln Asp Phe Thr Arg Asp His Val Pro Arg Gly Val Arg
     530                 535                 540

 aag gaa agc cag ctt gcc ggc cga atc gtg cag gaa aat ggg tgt gaa     1858
 Lys Glu Ser Gln Leu Ala Gly Arg Ile Val Gln Glu Asn Gly Cys Glu
 545                 550                 555                 560

 acc cac aac caa aca gcc cgc ggc ttc tgc ctg aga ccc cac gcc ctc     1906
 Thr His Asn Gln Thr Ala Arg Gly Phe Cys Leu Arg Pro His Ala Leu
                 565                 570                 575

 tcg gtg gat gat gtg ttc cag gga gct gac tgg gag agg cct gga agc     1954
 Ser Val Asp Asp Val Phe Gln Gly Ala Asp Trp Glu Arg Pro Gly Ser
             580                 585                 590

 cca ccc tct tat gaa gag gcc atg cag ggc ccg gca gcc aga cta gtg     2002
 Pro Pro Ser Tyr Glu Glu Ala Met Gln Gly Pro Ala Ala Arg Leu Val
         595                 600                 605

 gcc tcc gag agc cag acc gtg ggg agc atg acg gtg ggg agc atg agg     2050
 Ala Ser Glu Ser Gln Thr Val Gly Ser Met Thr Val Gly Ser Met Arg
     610                 615                 620

 gcg agg atg ctg gag gcg cac tgc ctc cta ccc cct ctt cca cct gct     2098
 Ala Arg Met Leu Glu Ala His Cys Leu Leu Pro Pro Leu Pro Pro Ala
 625                 630                 635                 640

 cac cac gta gag gac tca aga cac agg ggc agc aaa gag cca ctc cct     2146
 His His Val Glu Asp Ser Arg His Arg Gly Ser Lys Glu Pro Leu Pro
                 645                 650                 655

 ggc cac gga ctc tct ccc ctg cct gag cga tgg aaa cag agc aga act     2194
 Gly His Gly Leu Ser Pro Leu Pro Glu Arg Trp Lys Gln Ser Arg Thr
             660                 665                 670

 gtc cat gct tct ggg gac tct ctg ggg cac gtg tct ggc cca ggg aga     2242
 Val His Ala Ser Gly Asp Ser Leu Gly His Val Ser Gly Pro Gly Arg
         675                 680                 685

 cct gag ctc ctc ccg ctg agg acc gtc tcc gag tcc gtg cag agg aat     2290
 Pro Glu Leu Leu Pro Leu Arg Thr Val Ser Glu Ser Val Gln Arg Asn
     690                 695                 700

 aag cgg gac tgt ctc gtg cga cga tgt agc cag ccg gtc ttt gag gct     2338
 Lys Arg Asp Cys Leu Val Arg Arg Cys Ser Gln Pro Val Phe Glu Ala
 705                 710                 715                 720

 gac caa ttc caa tat gcc aaa gaa tcg tat att tag gagg gaggccatac     2388
 Asp Gln Phe Gln Tyr Ala Lys Glu Ser Tyr Ile 
                 725                 730

 gccatgccat agcttgtgct atctgtaaat atgagacttg taaagaactg cctgtagatt   2448

 gtttttaaaa ggtcttgaat aagctccttg agaaagttgt ggaaagccct cctcagtgag   2508

 gatagctaca ccatggccat ggcgcatcag atagtctctg tgtacctgga tttgtgcaat   2568

 atgtaaaaat gtatcaaatg tattatagat aaggtgttag gtgcaaagga tgtctgataa   2628

 tccctgcaca cgttttgaac ttgcagtgaa gtacactgct gttccttgct tcctggggca   2688

 cttttctctt ggttagtgtt taaaaattat cttcgctttt ttaatgtggc ctcaaatgtc   2748

 atgccaattt tcacatcttc cacaaactcc atttagggag aaatgtttaa atctctggta   2808

 taagtttact ccataccaga gtaaactata tattactcta tataagcagt cttgcaataa   2868

 ctaatcacca ccatagaaga aagaaacaga ctgcaaggaa cagagttgag tgtctggagt   2928

 catcaaaggc attaaaaact ccagtaaaag ctggggccgt agcaaaaatc atgaaaaaca   2988

 cttcaacgtg tcctttcaat catccaatta aatgtgggta gattaatgaa aatgtattac   3048

 atcaatatta actcatctat agcactttga gtatctttgt agttcatgat atcctatcct   3108

 ataatgtgga ggtaaatgat tttatatgca ttgggggtca tatataaaac ttcaatgtaa   3168

 tttcactaca ataaattgcc ttccttattt gaaagtaaaa aaaaaaaa                3216




      <210> 145
      <211> 695
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (274)..(606)

      <400> 145
 taccggtccg gaattcccgg gtcgacccac gcgtccgccc acgcgtccgc ccacgcgtcc     60

 gctagaagca agaggctgat tcagcgaatg tcttaaaaca ctagtcatca gataacaagg    120

 ctacagcctc gtgaactgga aaataagcaa tctgccagat attttgatgg aaagaaggaa    180

 aatttatgtg agattttaga tattagagac aactaagatg aaaaaacaga agttgatttt    240

 attttggaag actaagctca gtgtggtggt gct atg tca gac ttc agt ggt gtg     294
                                      Met Ser Asp Phe Ser Gly Val
                                        1               5

 atc ctc agt cct ggg ttt cct gga aac tat ccc agc agt tta gat tgc      342
 Ile Leu Ser Pro Gly Phe Pro Gly Asn Tyr Pro Ser Ser Leu Asp Cys
          10                  15                  20

 aca tgg aca ata aat cta ccc ata ggt ttt ggt gta cat ctc cag ttt      390
 Thr Trp Thr Ile Asn Leu Pro Ile Gly Phe Gly Val His Leu Gln Phe
      25                  30                  35

 gta aat ttt tct aca gaa acc ata cat gat tat ttg gaa gta cga agt      438
 Val Asn Phe Ser Thr Glu Thr Ile His Asp Tyr Leu Glu Val Arg Ser
  40                  45                  50                  55

 gga tcc tca gaa act agt act gtt att ggc cgg ctt agt ggt cct caa      486
 Gly Ser Ser Glu Thr Ser Thr Val Ile Gly Arg Leu Ser Gly Pro Gln
                  60                  65                  70

 ata cca tct tcc tta ttc agc acc acc cat gaa acc agc tta tat ttt      534
 Ile Pro Ser Ser Leu Phe Ser Thr Thr His Glu Thr Ser Leu Tyr Phe
              75                  80                  85

 cac agt gac tat tca caa aac aaa caa ggg ttt cat att gta tac caa      582
 His Ser Asp Tyr Ser Gln Asn Lys Gln Gly Phe His Ile Val Tyr Gln
          90                  95                 100

 ggt aag aga aat aat aaa aaa tga aaatttatat aaccccaaat cagctattag     636
 Gly Lys Arg Asn Asn Lys Lys 
     105                 110

 aaatatttaa ctgagtctaa ttattttctg tattctgttt tagaaagaaa aaaaaaaaa     695




      <210> 146
      <211> 754
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (237)..(569)

      <400> 146
 cccacgcgtc cgcccacgcg tccgctagaa gcaagaggct gattcagcga atgtcttaaa     60

 acactagtca tcagataaca aggctacagc ctcgtgaact ggaaaataag caatctgcca    120

 gatattttga tggaaagaag gaaaatttat gtgagatttt agatattaga gacaactaag    180

 atgaaaaaac agaagttgat tttattttgg aagactaagc tcagtgtggt ggtgct        236                                                                 
 atg tca gac ttc agt ggt gtg atc ctc agt cct ggg ttt cct gga aac      284
 Met Ser Asp Phe Ser Gly Val Ile Leu Ser Pro Gly Phe Pro Gly Asn
   1               5                  10                  15

 tat ccc agc agt tta gat tgc aca tgg aca ata aat cta ccc ata ggt      332
 Tyr Pro Ser Ser Leu Asp Cys Thr Trp Thr Ile Asn Leu Pro Ile Gly
              20                  25                  30

 ttt ggt gta cat ctc cag ttt gta aat ttt tct aca gaa acc ata cat      380
 Phe Gly Val His Leu Gln Phe Val Asn Phe Ser Thr Glu Thr Ile His
          35                  40                  45

 gat tat ttg gaa gta cga agt gga tcc tca gaa act agt act gtt att      428
 Asp Tyr Leu Glu Val Arg Ser Gly Ser Ser Glu Thr Ser Thr Val Ile
      50                  55                  60

 ggc cgg ctt agt ggt cct caa ata cca tct tcc tta ttc agc acc acc      476
 Gly Arg Leu Ser Gly Pro Gln Ile Pro Ser Ser Leu Phe Ser Thr Thr
  65                  70                  75                  80

 cat gaa acc agc tta tat ttt cac agt gac tat tca caa aac aaa caa      524
 His Glu Thr Ser Leu Tyr Phe His Ser Asp Tyr Ser Gln Asn Lys Gln
                  85                  90                  95

 ggg ttt cat att gta tac caa ggt aag aga aat aat aaa aaa tga aaa      572
 Gly Phe His Ile Val Tyr Gln Gly Lys Arg Asn Asn Lys Lys 
             100                 105                 110

 tttatataac cccaaatcag ctattagaaa tatttaactg agtctaatta ttttctgtat    632

 tctgttttag aaagaaaaaa aaaaaaaaaa gggggggccg ttttaaagga tccctggggg    692

 ggcccaagtt tacgcgggca tgcgacgtaa aagctttttc cttataggga gccgaataat    752

 aa                                                                   754




      <210> 147
      <211> 1684
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (436)..(1389)

      <400> 147
 agtactttcc tcactgcacg ctcttgcccc tactcttttc tctagtgccc gtgttcttcc     60

 cgacgcctga cctggcccgc ccgcctttcc agtctggccg ggcgggggcc tgaagcacgg    120

 cggctcgggc cgtgggaccg tgttcacacc ctttccagaa attcttggct ggtaaccgcg    180

 aaaccgactg gagcaggagc tgggagaact ggagaaaact gctctaatct cacttgactc    240

 cagctaggag ctgatgctgc atcgtaataa catttgcaga gcgctttcac aggcgctgga    300

 gtgacttgtc tgagattcct ccagaactga gccctttgtt ggaaccatac cccagcccat    360

 ggtcccatga ctaggtggat agtactcctt gtacctcctg caacccagaa ccctggctga    420

 ccactttgaa ggagg atg ctc cag cag gtc aat ggc cac aat ccg ggg tct     471
                  Met Leu Gln Gln Val Asn Gly His Asn Pro Gly Ser
                    1               5                  10

 gat ggc caa gcc agg gag tac ctc aga gaa gac ctg cag gag ttc ctg      519
 Asp Gly Gln Ala Arg Glu Tyr Leu Arg Glu Asp Leu Gln Glu Phe Leu
          15                  20                  25

 ggt ggg gag gtc ctg ctg tac aaa ctg gat gac ctc acc agg gtg aat      567
 Gly Gly Glu Val Leu Leu Tyr Lys Leu Asp Asp Leu Thr Arg Val Asn
      30                  35                  40

 cct gtg aca cta gag aca gtc ctg agg tgc ctg cag gcc cgg tac atg      615
 Pro Val Thr Leu Glu Thr Val Leu Arg Cys Leu Gln Ala Arg Tyr Met
  45                  50                  55                  60

 gca gac aca ttc tac acc aat gct ggc tgc acc ctg gta gcc ttg aac      663
 Ala Asp Thr Phe Tyr Thr Asn Ala Gly Cys Thr Leu Val Ala Leu Asn
                  65                  70                  75

 ccc ttc aag cct gtt cct cag ctc tac tcg ccc gag cta atg aga gag      711
 Pro Phe Lys Pro Val Pro Gln Leu Tyr Ser Pro Glu Leu Met Arg Glu
              80                  85                  90

 tac cat gct gcg cct cag ccc cag aaa ctg aag ccc cat gtg ttc act      759
 Tyr His Ala Ala Pro Gln Pro Gln Lys Leu Lys Pro His Val Phe Thr
          95                 100                 105

 gtg ggt gaa cag acc tac agg aat gtc aag agc ctg att gaa cca gtc      807
 Val Gly Glu Gln Thr Tyr Arg Asn Val Lys Ser Leu Ile Glu Pro Val
     110                 115                 120

 aac cag tct att gtt gtc agt gga gag agt ggt gct gga aag aca tgg      855
 Asn Gln Ser Ile Val Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Trp
 125                 130                 135                 140

 acg tct cgc tgc cta atg aag ttc tat gct gtg gtg gcc acc tca cct      903
 Thr Ser Arg Cys Leu Met Lys Phe Tyr Ala Val Val Ala Thr Ser Pro
                 145                 150                 155

 gca tct tgg gag agc cac aag att gca gag agg ata gaa cag agg atc      951
 Ala Ser Trp Glu Ser His Lys Ile Ala Glu Arg Ile Glu Gln Arg Ile
             160                 165                 170

 ctg aac tcc aac cct gtc atg gaa gct ttt ggg aat gcg tgt aca ctg      999
 Leu Asn Ser Asn Pro Val Met Glu Ala Phe Gly Asn Ala Cys Thr Leu
         175                 180                 185

 agg aat aac aac agc agt cgc ttt ggg aag ttc atc cag ctc cag ctg     1047
 Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys Phe Ile Gln Leu Gln Leu
     190                 195                 200

 aac agg gct cag caa atg act gga gcc gca gtc cag acc tac ctc cta     1095
 Asn Arg Ala Gln Gln Met Thr Gly Ala Ala Val Gln Thr Tyr Leu Leu
 205                 210                 215                 220

 gag aaa act cga gtg gcc tgc cag gct tcc agt gag agg aac ttc cac     1143
 Glu Lys Thr Arg Val Ala Cys Gln Ala Ser Ser Glu Arg Asn Phe His
                 225                 230                 235

 atc ttc tat cag att tgc aaa gga gcc agt gag gac gag agg ctc cag     1191
 Ile Phe Tyr Gln Ile Cys Lys Gly Ala Ser Glu Asp Glu Arg Leu Gln
             240                 245                 250

 tgg cac ctt cct gag gga gct gcc ttc tcc tgg ctg ccc aac cca gag     1239
 Trp His Leu Pro Glu Gly Ala Ala Phe Ser Trp Leu Pro Asn Pro Glu
         255                 260                 265

 agg agc tta gaa gag gat tgt ttt gag gtg acc aga gag gcc atg ctc     1287
 Arg Ser Leu Glu Glu Asp Cys Phe Glu Val Thr Arg Glu Ala Met Leu
     270                 275                 280

 cat ttg ggc att gac acc cct acc cag aac aac atc ttt aag gtc aga     1335
 His Leu Gly Ile Asp Thr Pro Thr Gln Asn Asn Ile Phe Lys Val Arg
 285                 290                 295                 300

 aga aaa gcc acg cca ctt aag ttt ggc aga gat gac ggg cag ccc ttt     1383
 Arg Lys Ala Thr Pro Leu Lys Phe Gly Arg Asp Asp Gly Gln Pro Phe
                 305                 310                 315

 gca tag agcttttccc tggacttgga gttggtcttt ccctgaggat ctaggacttt      1439
 Ala 


 gggcccttct gtgctacctc caaggaatca gtcacctctg ttctgctgag tctggagacc   1499

 aggtggtggg gtggacgggg cataaggaag agtgatgcat acacagtgct agagtacaga   1559

 atgcagtaag tgatccatgg gggcagagag caaggtaccg catgatcaga agagagaact   1619

 agtgctaccg ccttgcttgt ctagtacatt aaaacttaca agtcatgttc aaaaaaaaaa   1679

 aaaaa                                                               1684




      <210> 148
      <211> 2025
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (436)..(1689)

      <400> 148
 agtactttcc tcactgcacg ctcttgcccc tactcttttc tctagtgccc gtgttcttcc     60

 cgacgcctga cctggcccgc ccgcctttcc agtctggccg ggcgggggcc tgaagcacgg    120

 cggctcgggc cgtgggaccg tgttcacacc ctttccagaa attcttggct ggtaaccgcg    180

 aaaccgactg gagcaggagc tgggagaact ggagaaaact gctctaatct cacttgactc    240

 cagctaggag ctgatgctgc atcgtaataa catttgcaga gcgctttcac aggcgctgga    300

 gtgacttgtc tgagattcct ccagaactga gccctttgtt ggaaccatac cccagcccat    360

 ggtcccatga ctaggtggat agtactcctt gtacctcctg caacccagaa ccctggctga    420

 ccactttgaa ggagg atg ctc cag cag gtc aat ggc cac aat ccg ggg tct     471
                  Met Leu Gln Gln Val Asn Gly His Asn Pro Gly Ser
                    1               5                  10

 gat ggc caa gcc agg gag tac ctc aga gaa gac ctg cag gag ttc ctg      519
 Asp Gly Gln Ala Arg Glu Tyr Leu Arg Glu Asp Leu Gln Glu Phe Leu
          15                  20                  25

 ggt ggg gag gtc ctg ctg tac aaa ctg gat gac ctc acc agg gtg aat      567
 Gly Gly Glu Val Leu Leu Tyr Lys Leu Asp Asp Leu Thr Arg Val Asn
      30                  35                  40

 cct gtg aca cta gag aca gtc ctg agg tgc ctg cag gcc cgg tac atg      615
 Pro Val Thr Leu Glu Thr Val Leu Arg Cys Leu Gln Ala Arg Tyr Met
  45                  50                  55                  60

 gca gac aca ttc tac acc aat gct ggc tgc acc ctg gta gcc ttg aac      663
 Ala Asp Thr Phe Tyr Thr Asn Ala Gly Cys Thr Leu Val Ala Leu Asn
                  65                  70                  75

 ccc ttc aag cct gtt cct cag ctc tac tcg ccc gag cta atg aga gag      711
 Pro Phe Lys Pro Val Pro Gln Leu Tyr Ser Pro Glu Leu Met Arg Glu
              80                  85                  90

 tac cat gct gcg cct cag ccc cag aaa ctg aag ccc cat gtg ttc act      759
 Tyr His Ala Ala Pro Gln Pro Gln Lys Leu Lys Pro His Val Phe Thr
          95                 100                 105

 gtg ggt gaa cag acc tac agg aat gtc aag agc ctg att gaa cca gtc      807
 Val Gly Glu Gln Thr Tyr Arg Asn Val Lys Ser Leu Ile Glu Pro Val
     110                 115                 120

 aac cag tct att gtt gtc agt gga gag agt ggt gct gga aag aca tgg      855
 Asn Gln Ser Ile Val Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Trp
 125                 130                 135                 140

 acg tct cgc tgc cta atg aag ttt tat gct gtg gtg gcc gcc tca cct      903
 Thr Ser Arg Cys Leu Met Lys Phe Tyr Ala Val Val Ala Ala Ser Pro
                 145                 150                 155

 gca tct tgg gag agc cac aag att gca gag agg ata gaa cag agg atc      951
 Ala Ser Trp Glu Ser His Lys Ile Ala Glu Arg Ile Glu Gln Arg Ile
             160                 165                 170

 ctg aac tcc aac cct gtc atg gaa gct ttt ggg aat gcg tgt aca ctg      999
 Leu Asn Ser Asn Pro Val Met Glu Ala Phe Gly Asn Ala Cys Thr Leu
         175                 180                 185

 agg aat aac aac agc agt cgc ttt ggg aag ttc atc cag ctc cag ctg     1047
 Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys Phe Ile Gln Leu Gln Leu
     190                 195                 200

 aac agg gct cag caa atg act gga gcc gca gtc cag acc tac ctc cta     1095
 Asn Arg Ala Gln Gln Met Thr Gly Ala Ala Val Gln Thr Tyr Leu Leu
 205                 210                 215                 220

 gag aaa act cga gtg gcc tgc cag gct tcc agt gag agg aac ttc cac     1143
 Glu Lys Thr Arg Val Ala Cys Gln Ala Ser Ser Glu Arg Asn Phe His
                 225                 230                 235

 atc ttc tat cag att tgc aaa gga gcc agt gag gac gag agg ctc cag     1191
 Ile Phe Tyr Gln Ile Cys Lys Gly Ala Ser Glu Asp Glu Arg Leu Gln
             240                 245                 250

 tgg cac ctt cct gag gga gct gcc ttc tcc tgg ctg ccc aac cca gag     1239
 Trp His Leu Pro Glu Gly Ala Ala Phe Ser Trp Leu Pro Asn Pro Glu
         255                 260                 265

 agg agc tta gaa gag gat tgt ttt gag gtg acc aga gag gcc atg ctc     1287
 Arg Ser Leu Glu Glu Asp Cys Phe Glu Val Thr Arg Glu Ala Met Leu
     270                 275                 280

 cat ttg ggc att gac acc cct acc cag aac aac atc ttt aag gtc cta     1335
 His Leu Gly Ile Asp Thr Pro Thr Gln Asn Asn Ile Phe Lys Val Leu
 285                 290                 295                 300

 gct gga ctg ctg cac ctt ggc aat atc cag ttt gct gcc tcc gag gat     1383
 Ala Gly Leu Leu His Leu Gly Asn Ile Gln Phe Ala Ala Ser Glu Asp
                 305                 310                 315

 gaa gcc cag ccc tgc cag ccg atg gat gat gcc aag tac tct gtc agg     1431
 Glu Ala Gln Pro Cys Gln Pro Met Asp Asp Ala Lys Tyr Ser Val Arg
             320                 325                 330

 acg gca gcc tcg ctg ctg ggg ctc cca gag gac gtg ctg ctg gag atg     1479
 Thr Ala Ala Ser Leu Leu Gly Leu Pro Glu Asp Val Leu Leu Glu Met
         335                 340                 345

 gtg cag att aga acc atc agg gca ggc aga cag cag cag gtg ttc cgg     1527
 Val Gln Ile Arg Thr Ile Arg Ala Gly Arg Gln Gln Gln Val Phe Arg
     350                 355                 360

 aag ccc tgc gcc cga gcc gag tgt gac acc cgt aga gac tgc ctg gcc     1575
 Lys Pro Cys Ala Arg Ala Glu Cys Asp Thr Arg Arg Asp Cys Leu Ala
 365                 370                 375                 380

 aaa ctg atc tat gcg cgg ttg ttg act ggg ctg gta tca cgt gat caa     1623
 Lys Leu Ile Tyr Ala Arg Leu Leu Thr Gly Leu Val Ser Arg Asp Gln
                 385                 390                 395

 agc aac atc tcg ggc aga cac gac tcg tgg aac cac tta cat agg ctg     1671
 Ser Asn Ile Ser Gly Arg His Asp Ser Trp Asn His Leu His Arg Leu
             400                 405                 410

 ctg aat gcg atg gct tga cacaat tctgtacaac agactgcaac agatgggctt     1725
 Leu Asn Ala Met Ala 
         415

 aaatagacca agaaaacctg aagaagcatt tgcgggcacc tacgtaagag ccaacgtagc   1785

 ataaccaaga cgggccggag aagcacacaa aaatacacgg acacaaccgc agagagccaa   1845

 aataaaggag accacacaaa agacacacta aaacgaagag agcaaacaaa caaagagaca   1905

 acaagacaag aaaataccga gcgagccctg agacaaaaac aagcaaacga gaaacggcac   1965

 aaccagaacg acagaaacca caagagatac caacgacata caacagacag acaacacgta   2025




      <210> 149
      <211> 681
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (420)..(584)

      <400> 149
 gcccaactgg atttctccct ggtgctccaa atgactttgt acaagtgctg gagttagcac     60

 ctccctctgc ccttaactgg cggaaatggg ttcattttcc attattgcaa gagaatggaa    120

 gtcttaatag aaggaagcag gagtgattag ttcgggttaa agcaaaagtg tgtcatgaac    180

 ttggattccc tgaagtcagt tttgtcaggt tcatggccca ctttgctaca gcatcagagt    240

 gaagcacgcc tgtctaggtt ctccagtgac agaaagatcc tgaagcatgg actaacatgc    300

 tctctggagc ttagtactcc agagctagat cctgatgggt ctctaaggtt ccctccaaga    360

 agacaaggac aggagacttg ggaaggacca atggtaattt aagtggctct taaaaagtc     419                                                                 
 atg caa cat gtt tct gga cac gtt cct gat cct att gcg ata atg tat      467
 Met Gln His Val Ser Gly His Val Pro Asp Pro Ile Ala Ile Met Tyr
   1               5                  10                  15

 gtg tgc cct ccc tgt ggg cac acc acc tgg gca tta gga ctg aaa ttc      515
 Val Cys Pro Pro Cys Gly His Thr Thr Trp Ala Leu Gly Leu Lys Phe
              20                  25                  30

 ctg agt tct tcc tct caa aat ttc tgt gca cca gta tta ttc ctc att      563
 Leu Ser Ser Ser Ser Gln Asn Phe Cys Ala Pro Val Leu Phe Leu Ile
          35                  40                  45

 tta cat aca gga ggc aac taa ga ctcatacagg gctcaactga ataagaggct      616
 Leu His Thr Gly Gly Asn 
      50

 taagaggata aactggagca gaaataagcc ttaggtgctg cccagtttac acttcctggg    676

 atgga                                                                681




      <210> 150
      <211> 3726
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (631)..(1959)

      <400> 150
 gaatccaact ggactttatt tgacacagaa tacaatatgg ctacagaaac agcaaactga     60

 aaaaacaaag cagaaaaaaa cacagttcca tccaatttgt aattaggtaa cagcagggaa    120

 agtcattaaa tgaataacaa aacaattaag cttgatggaa gaagtctttt cctagtgccc    180

 atacttttgg aattcccact ctctgttgtc caatggacac acctgtcgtg ttttgagcca    240

 gcgagagatg cagtggaagt gaaaagcatg gttacagact ccccatgcga cagtacactc    300

 ttctgaagta gcggacgcct ggttagcttg acattctatg caaagatcca taatgtggtt    360

 cctgcagatg gcacagttat caaccacaat atcccaggcc cagagggcta ctgcattcca    420

 ctttttcact tcaaagcgct tcttgcccgc gccgctgttg gtgccgctcg gggtatccac    480

 atccatcgct gcgggctcac aaagcggcca gacgctcggc ggcggcgtgt ggcaggagcg    540

 caggggcgcg agccggcgat cagccttccc ggcgaccgtg ccgcgggagc tcgagcaact    600

 cggactaggg gacccgggcc ggcccccaag     atg ccg gcg atc gcg gtg ttg     651
                                      Met Pro Ala Ile Ala Val Leu
                                        1               5

 gcg gcg gcc gcc gcg gcg tgg tgc ttc ctc caa gtc gag agc cgg cac      699
 Ala Ala Ala Ala Ala Ala Trp Cys Phe Leu Gln Val Glu Ser Arg His
          10                  15                  20

 ctg gac gcg ctc gcc gga ggc gcg ggc ccc aac cac ggc aat ttc cta      747
 Leu Asp Ala Leu Ala Gly Gly Ala Gly Pro Asn His Gly Asn Phe Leu
      25                  30                  35

 gac aat gac cag tgg ctg agc acc gtc tcc cag tac gac cgg gac aag      795
 Asp Asn Asp Gln Trp Leu Ser Thr Val Ser Gln Tyr Asp Arg Asp Lys
  40                  45                  50                  55

 tac tgg aac cgc ttt cga gac gaa gtt gag gat gat tat ttc aga aac      843
 Tyr Trp Asn Arg Phe Arg Asp Glu Val Glu Asp Asp Tyr Phe Arg Asn
                  60                  65                  70

 tgg aat ccc aac aag ccc ttt gac caa gcc ctg gac cca tcc aag gac      891
 Trp Asn Pro Asn Lys Pro Phe Asp Gln Ala Leu Asp Pro Ser Lys Asp
              75                  80                  85

 ccc tgc ctg aag gta aaa tgc agc cct cac aaa gtg tgt gtg acc cag      939
 Pro Cys Leu Lys Val Lys Cys Ser Pro His Lys Val Cys Val Thr Gln
          90                  95                 100

 gac tac cag acc gcc ctg tgt gtc agc cgc aag cac ctg ctc ccc agg      987
 Asp Tyr Gln Thr Ala Leu Cys Val Ser Arg Lys His Leu Leu Pro Arg
     105                 110                 115

 caa aag aag ggg aac gtg gcc cag aaa cac tgg gtt gga cct tcg aat     1035
 Gln Lys Lys Gly Asn Val Ala Gln Lys His Trp Val Gly Pro Ser Asn
 120                 125                 130                 135

 ttg gtc aag tgc aag ccc tgt ccc gtg gca cag tca gcc atg gtc tgc     1083
 Leu Val Lys Cys Lys Pro Cys Pro Val Ala Gln Ser Ala Met Val Cys
                 140                 145                 150

 ggc tca gat ggc cac tcc tac aca tcc aag tgc aaa ttg gag ttc cat     1131
 Gly Ser Asp Gly His Ser Tyr Thr Ser Lys Cys Lys Leu Glu Phe His
             155                 160                 165

 gct tgt tct act ggc aaa agc ctc gcc acc ctc tgt gat ggg ccc tgt     1179
 Ala Cys Ser Thr Gly Lys Ser Leu Ala Thr Leu Cys Asp Gly Pro Cys
         170                 175                 180

 ccc tgt ctc cca gag cct gag cca cca aag cac aag gca gaa agg agt     1227
 Pro Cys Leu Pro Glu Pro Glu Pro Pro Lys His Lys Ala Glu Arg Ser
     185                 190                 195

 gcc tgc aca gac aag gag ttg cgg aac ctt gcc tcc cgg ctg aag gat     1275
 Ala Cys Thr Asp Lys Glu Leu Arg Asn Leu Ala Ser Arg Leu Lys Asp
 200                 205                 210                 215

 tgg ttt gga gct ctc cac gag gat gcg aac aga gtc atc aag ccc acc     1323
 Trp Phe Gly Ala Leu His Glu Asp Ala Asn Arg Val Ile Lys Pro Thr
                 220                 225                 230

 agc tcc aac aca gcc caa ggc agg ttt gac act agc atc ctg ccc atc     1371
 Ser Ser Asn Thr Ala Gln Gly Arg Phe Asp Thr Ser Ile Leu Pro Ile
             235                 240                 245

 tgc aag gac tcc ctg ggc tgg atg ttc aac aag ttg gac atg aac tat     1419
 Cys Lys Asp Ser Leu Gly Trp Met Phe Asn Lys Leu Asp Met Asn Tyr
         250                 255                 260

 gac ctc ctg ctt gac cct tca gag atc aat gcc atc tac ctg gat aag     1467
 Asp Leu Leu Leu Asp Pro Ser Glu Ile Asn Ala Ile Tyr Leu Asp Lys
     265                 270                 275

 tac gag ccc tgt atc aag cct ctt ttc aac tcg tgt gac tcc ttc aag     1515
 Tyr Glu Pro Cys Ile Lys Pro Leu Phe Asn Ser Cys Asp Ser Phe Lys
 280                 285                 290                 295

 gat ggc aag ctt tct aac aat gag tgg tgc tac tgc ttc cag aag cct     1563
 Asp Gly Lys Leu Ser Asn Asn Glu Trp Cys Tyr Cys Phe Gln Lys Pro
                 300                 305                 310

 gga ggt ctc cct tgc cag aat gaa atg aac aga att cag aag ctg agt     1611
 Gly Gly Leu Pro Cys Gln Asn Glu Met Asn Arg Ile Gln Lys Leu Ser
             315                 320                 325

 aag ggg aaa agc ctg ttg ggg gcc ttc ata cct cgg tgt aat gag gag     1659
 Lys Gly Lys Ser Leu Leu Gly Ala Phe Ile Pro Arg Cys Asn Glu Glu
         330                 335                 340

 ggc tat tac aaa gcc aca cag tgc cac ggc agc acg ggg cag tgc tgg     1707
 Gly Tyr Tyr Lys Ala Thr Gln Cys His Gly Ser Thr Gly Gln Cys Trp
     345                 350                 355

 tgt gtg gac aaa tat ggg aat gag ttg gct ggc tcc agg aaa cag ggt     1755
 Cys Val Asp Lys Tyr Gly Asn Glu Leu Ala Gly Ser Arg Lys Gln Gly
 360                 365                 370                 375

 gct gtg agc tgt gaa gag gag cag gaa acc tca ggg gat ttt ggc agt     1803
 Ala Val Ser Cys Glu Glu Glu Gln Glu Thr Ser Gly Asp Phe Gly Ser
                 380                 385                 390

 ggt ggg tcc gtg gtc ctg ctg gat gac cta gaa tat gaa cgg gag ctg     1851
 Gly Gly Ser Val Val Leu Leu Asp Asp Leu Glu Tyr Glu Arg Glu Leu
             395                 400                 405

 gga cca aag gac aaa gag ggg aag ctg agg gtg cac acc cga gcc gtg     1899
 Gly Pro Lys Asp Lys Glu Gly Lys Leu Arg Val His Thr Arg Ala Val
         410                 415                 420

 aca gag gat gat gag gat gag gat gat gac aaa gag gat gag gtc ggg     1947
 Thr Glu Asp Asp Glu Asp Glu Asp Asp Asp Lys Glu Asp Glu Val Gly
     425                 430                 435

 tac ata tgg tag tgc ccacaagaaa gaggacacaa gttttgcaca aaattgcaag     2002
 Tyr Ile Trp 
 440

 tcacttccta ttcctgcatt tgtatctaag actccaaggc accaaggtct cttctccatt   2062

 gttgctctct atacccgacc taaggtttgg aagacaactg cttgttccca gaggattctg   2122

 attttgcata tgtttgtatg ggagaaaggg tgttgtgttt tttttttttg ttgttgttta   2182

 ttttttggat agggaagtca ttggcttaat tagagcctcc ttcctttctg tgagattttt   2242

 ccaacaagca tgtgatttac gtggaattct gacagtgcag ggagccccca ccctcttaaa   2302

 tgtcaaagac cctttttgat tacccacact ggtggttatt acagcatggt tcccagcctt   2362

 acagtgtcta agtgcttctc ttgtgtcctg tagatgttgt gaaaaagaaa aaaacaaaaa   2422

 atacaccaca ctgtactttt tccccctgcc cccgttactg ccggtgatta ttattaaaaa   2482

 ttagtttttt tcacatcatt atatctggct tcctataaac aacagcctta attcagtcaa   2542

 gactcccttt ggggaattca ttttattaaa aattggtgtc tggatacttc cctgtacatg   2602

 cataaatatg catgcatgta cagaaagact gtatgtgtgt gccttgcaca cacacccata   2662

 cctctcagaa aaagtgggta tcttaaaaac tcgaaaaaca atgataaatt tctcagcttg   2722

 tccagacctg gaacaaaatt tctggaataa gaaatttgta ttaaagtcct tttttgcact   2782

 aacagttggc tcttgtagcc tgcaggctga ggaagtctct tctctgtgca tcagcagagt   2842

 tactgaaagc ctctgattga gaaaaaacct ccgtctgcct aaatcacttt tctcgcagaa   2902

 gccatgcgac tcccacacga cacgggcagc ttcacaagcc atctctttca tttctgcttg   2962

 aagccccctt ggctgcagca atcctgtctg ccataggttt cttccttcct tacctactca   3022

 agggcttttt ctaaggcatg cacacatatc tcctgttctc tgagagtacc atggtgttcc   3082

 ttaaaagaag aaaatttcta attctgaact caatgttttg cttttactcc ctttctactg   3142

 acaaatcatg ataagggcac aaaagctgta cagatttttt tttttaacca ctcaatccca   3202

 aatggaggcc tacaaagaac atcgtaataa cacatggaag caaaccccgg gtttttaaga   3262

 gcaaattctg tccccccctc actcccccaa gtgacaagat actaatgaag aaagttcttc   3322

 accatagtgt ttgttttaac taaactcatt ggagtctagt tccaaatttg gtagggtcat   3382

 catctctaca ttccttagga tttctctccc tatcaagctg gcccagatac aagtaccaaa   3442

 cagtagtctc tgaagttccc ccatttcctt cagtaccagt ctataagcta ctgtccgcca   3502

 ctgattttca tctatcaggg tgtcctaatc agaatcagcc acccaagcaa gcctctctgg   3562

 cccacatatc tatctcttgc cttcccccat gaacttcagc ctgtccacac aaaagccaca   3622

 taaactcaag caagaaatat gttcagccaa aacatgatta tagtggcagc tgaccaatcc   3682

 cccaccccaa tcaacctcta tgctttcttc ttaaaaaaaa aaaa                    3726




      <210> 151
      <211> 2934
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(1721)

      <400> 151
 cgcgccgcac c atg gcg ccc acc ctg gcc act gcc cat cgg cgc cgc tgg      50
              Met Ala Pro Thr Leu Ala Thr Ala His Arg Arg Arg Trp
                1               5                  10

 tgg atg gcc tgc acg gcc gtg ctg gag aac ctc ctc ttc tcg gca gtc       98
 Trp Met Ala Cys Thr Ala Val Leu Glu Asn Leu Leu Phe Ser Ala Val
      15                  20                  25

 ctc ctg ggc tgg ggc tcg ctg ctc atc atg ctc aag tca gag ggc ttt      146
 Leu Leu Gly Trp Gly Ser Leu Leu Ile Met Leu Lys Ser Glu Gly Phe
  30                  35                  40                  45

 tac tcc tac ctg tgt acc gag cca gag aat gtc acc aat ggc aca gtg      194
 Tyr Ser Tyr Leu Cys Thr Glu Pro Glu Asn Val Thr Asn Gly Thr Val
                  50                  55                  60

 ggc ggc aca gca gag ccg ggg cac gag gag gtg agc tgg atg aac ggc      242
 Gly Gly Thr Ala Glu Pro Gly His Glu Glu Val Ser Trp Met Asn Gly
              65                  70                  75

 tgg ctc agc tgc cag gcc cag gac gag atg cta aat ttg gcc ttc act      290
 Trp Leu Ser Cys Gln Ala Gln Asp Glu Met Leu Asn Leu Ala Phe Thr
          80                  85                  90

 gtg ggc tcc ttt ctg ctc agt gcc atc acc ctg ccc ctg ggt atc gtc      338
 Val Gly Ser Phe Leu Leu Ser Ala Ile Thr Leu Pro Leu Gly Ile Val
      95                 100                 105

 atg gac aag tat ggc ccg agg aag ctc agg ctg ctg ggc agc gcc tgc      386
 Met Asp Lys Tyr Gly Pro Arg Lys Leu Arg Leu Leu Gly Ser Ala Cys
 110                 115                 120                 125

 ttc gcg gtt tcc tgc ttg ctg att gcg tac gga gca aga aaa cca aac      434
 Phe Ala Val Ser Cys Leu Leu Ile Ala Tyr Gly Ala Arg Lys Pro Asn
                 130                 135                 140

 gct ctc tcc gtg ctc acc ttc atc gcc ctg gct ctg aat ggc ttt ggt      482
 Ala Leu Ser Val Leu Thr Phe Ile Ala Leu Ala Leu Asn Gly Phe Gly
             145                 150                 155

 ggg atg tgt atg acc ttc acc tca tta aca ctg ccc aac atg ttc ggc      530
 Gly Met Cys Met Thr Phe Thr Ser Leu Thr Leu Pro Asn Met Phe Gly
         160                 165                 170

 gac ctt cgg ttc acg ttt att gcc ttg atg att ggg tcc tac gcc tcc      578
 Asp Leu Arg Phe Thr Phe Ile Ala Leu Met Ile Gly Ser Tyr Ala Ser
     175                 180                 185

 tcg gca gtc acc ttt cca gga atc aag ctc atc tat gat gct ggt gtc      626
 Ser Ala Val Thr Phe Pro Gly Ile Lys Leu Ile Tyr Asp Ala Gly Val
 190                 195                 200                 205

 tcc ttc atc gtc gtc ctc gtg gtc tgg gcc ggc tgc tcc ggg ctg gtt      674
 Ser Phe Ile Val Val Leu Val Val Trp Ala Gly Cys Ser Gly Leu Val
                 210                 215                 220

 ttc ctc aac tgc ttc ttt aac tgg ccc ctt gag ccc ttc ccg ggg ccg      722
 Phe Leu Asn Cys Phe Phe Asn Trp Pro Leu Glu Pro Phe Pro Gly Pro
             225                 230                 235

 gag gac atg gac tac tcg gtg aag atc aag ttc agc tgg ctg ggc ttt      770
 Glu Asp Met Asp Tyr Ser Val Lys Ile Lys Phe Ser Trp Leu Gly Phe
         240                 245                 250

 gac cac aag atc aca ggg aag cag ttc tac aag cag gtg acc acg gtg      818
 Asp His Lys Ile Thr Gly Lys Gln Phe Tyr Lys Gln Val Thr Thr Val
     255                 260                 265

 ggc cgg cgc ctg agt gtg ggc agc tcc atg agg agt gcc aag gag cag      866
 Gly Arg Arg Leu Ser Val Gly Ser Ser Met Arg Ser Ala Lys Glu Gln
 270                 275                 280                 285

 gtg gcg ctg cag gag ggc cac aag ctg tgc ctg tcc acc gtc gac ctg      914
 Val Ala Leu Gln Glu Gly His Lys Leu Cys Leu Ser Thr Val Asp Leu
                 290                 295                 300

 gag gtg aag tgc cag ccg gat gct gca gtg gcc ccc tcc ttc atg cac      962
 Glu Val Lys Cys Gln Pro Asp Ala Ala Val Ala Pro Ser Phe Met His
             305                 310                 315

 agc gtg ttc agc ccc atc ctg ctg ctc agc ctg gtc acc atg tgc gtc     1010
 Ser Val Phe Ser Pro Ile Leu Leu Leu Ser Leu Val Thr Met Cys Val
         320                 325                 330

 acg cag ctg cgg ctc atc ttc tac atg ggg gct atg aac aac atc ctc     1058
 Thr Gln Leu Arg Leu Ile Phe Tyr Met Gly Ala Met Asn Asn Ile Leu
     335                 340                 345

 aag ttc ctg gtc agc ggc gac cag aag aca gtt ggc ctc tac acc tcc     1106
 Lys Phe Leu Val Ser Gly Asp Gln Lys Thr Val Gly Leu Tyr Thr Ser
 350                 355                 360                 365

 atc ttc ggc gtg ctc cag ctg ctg tgc ctg ctg acg gcc ccc gtc att     1154
 Ile Phe Gly Val Leu Gln Leu Leu Cys Leu Leu Thr Ala Pro Val Ile
                 370                 375                 380

 ggc tac atc atg gac tgg agg ctg aag gag tgt gaa gac gcc tcc gag     1202
 Gly Tyr Ile Met Asp Trp Arg Leu Lys Glu Cys Glu Asp Ala Ser Glu
             385                 390                 395

 gag ccc gag gag aaa gac gcc aac caa ggc gag aag aaa aag aag aag     1250
 Glu Pro Glu Glu Lys Asp Ala Asn Gln Gly Glu Lys Lys Lys Lys Lys
         400                 405                 410

 cgg gac cgg cag atc cag aag atc act aat gcc atg cgg gcc ttc gcc     1298
 Arg Asp Arg Gln Ile Gln Lys Ile Thr Asn Ala Met Arg Ala Phe Ala
     415                 420                 425

 ttc acc aac ctg ctg ctc gtg ggc ttt ggg gtg acc tgc ctc att ccc     1346
 Phe Thr Asn Leu Leu Leu Val Gly Phe Gly Val Thr Cys Leu Ile Pro
 430                 435                 440                 445

 aac ctg cct ctc cag atc ctc tcc ttc atc ctg cac aca atc gtg cga     1394
 Asn Leu Pro Leu Gln Ile Leu Ser Phe Ile Leu His Thr Ile Val Arg
                 450                 455                 460

 gga ttc atc cac tcc gct gtc ggg ggc ctg tac gct gcc gtg tac ccc     1442
 Gly Phe Ile His Ser Ala Val Gly Gly Leu Tyr Ala Ala Val Tyr Pro
             465                 470                 475

 tcc acc cag ttc ggc agc ctc acg gga ctg cag tct ctg atc agc gcg     1490
 Ser Thr Gln Phe Gly Ser Leu Thr Gly Leu Gln Ser Leu Ile Ser Ala
         480                 485                 490

 ctc ttc gcc ctt ctg cag cag ccg ctg ttt ctg gcc atg atg ggt cct     1538
 Leu Phe Ala Leu Leu Gln Gln Pro Leu Phe Leu Ala Met Met Gly Pro
     495                 500                 505

 ctc cag gga gac cct ctg tgg gtg aac gtg ggg ctg ctc ctt ctc agc     1586
 Leu Gln Gly Asp Pro Leu Trp Val Asn Val Gly Leu Leu Leu Leu Ser
 510                 515                 520                 525

 ctg ctg ggc ttc tgc ctc ccg ctc tac ctg atc tgc tac cgg cgc cag     1634
 Leu Leu Gly Phe Cys Leu Pro Leu Tyr Leu Ile Cys Tyr Arg Arg Gln
                 530                 535                 540

 ctg gag cgg cag ctg cag cag agg cag gag gat gac aaa ctc ttc ctc     1682
 Leu Glu Arg Gln Leu Gln Gln Arg Gln Glu Asp Asp Lys Leu Phe Leu
             545                 550                 555

 aaa atc aac ggc tcg tcc aac cag gag gcc ttc gtg tag tggctgccgc      1731
 Lys Ile Asn Gly Ser Ser Asn Gln Glu Ala Phe Val 
         560                 565

 ctcggaactg cggtctcctg cctgtgcttc agtgactgac ccctgtcctg cccctccaga   1791

 gtaccccacg cacccccagg accttcgccg tctccgtgcc agcgttcacg ctccctcccg   1851

 gggccctgcc tcggagctct gtggtggaag gacgggagag ggccccggac acgcgcgttt   1911

 tctcctgccg aacgcagggg ctgccctgac tttgctctgc cgccccccgg ggacccgggg   1971

 cctggggtct ctgtggtgcc tgcagcagga gccaggaacg cccggcaggc aggcgctctc   2031

 ccgccagtgt ctggattctg cctcttgcca aagcagaggg ggctgccatc ccctgcctgc   2091

 cacctgcccc tcggctgcat gcccacagcc gtacctgcct gaggacaaag gcttgcactg   2151

 tctcgcccgc gcctggcccc caccccctcc ccggccagcc tgaggctgcc tgaggaagga   2211

 aggacccgct tcctgttgtc ggtgctaatt cctttgtaat tccagccccc tgtcgcctgt   2271

 ccagggcctg cccacccgtt ggaggccggt ggagaagccc cacctggctt atgccctgga   2331

 gagggtttag cgggctgggt ggacccctcg cctcctcccc gagggccaat gccgcggaca   2391

 cgttttcact gtcaccctcg ttctgtctgc cacctgaagg gaatttgagg accgccgcca   2451

 gggcaccccg tacatacaca cagctgcttt tgtggaggtg gacgaaaggc tgtggccggc   2511

 agacgtggag gtccaggccg gggtggggac gtgggtgggt ccgaggggtg tgtggggtcg   2571

 gggtgggctc taggagttag cccttatccc cactgaccag gcgggagccg ccaggcctgc   2631

 agctgggcca gtgcccagga gccatcctgg cgtggggcca ggagcttgtc caaggccaca   2691

 ggcccacagc accccctgcc ggcgggctcc gtggggccct ggagctgatg acgggggagg   2751

 cccgtccgcc tggcccacca acccgcccac cttgactgcc cccagaagtg tgtcttgaga   2811

 cctcctgggc gtgcttagag gggtgagttg tgtttggatt tttagttatt ttctcttcag   2871

 ttttattaga cttctttttt ataaagcaat aaatccattt tcctccgggt aaaaaaaaaa   2931

 aaa                                                                 2934




      <210> 152
      <211> 3225
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (300)..(2009)

      <400> 152
 gtctcgggcg cgggcgggag ggcacctgta ggtccctggg agaggcagcc ctcggatctg     60

 cccctgccca cctcacgctg cgttccatgc tggccccagg cgatgtcagt cctgctgcag    120

 gccaggacta gttccacggc cctgagcatg cgttagcccc ttcttgcctc catgcctcag    180

 tttacctcgg agtgagctgc gggagacgtc tccctgcctg gccggggcgg ctctgtcgta    240

 gcggagggca caggtggtgc agagccggag ccggagccgg agccgcgccg cgccgcacc     299                                                                 
 atg gcg ccc acc ctg gcc act gcc cat cgg cgc cgc tgg tgg atg gcc      347
 Met Ala Pro Thr Leu Ala Thr Ala His Arg Arg Arg Trp Trp Met Ala
   1               5                  10                  15

 tgc acg gcc gtg ctg gag aac ctc ctc ttc tcg gca gtc ctc ctg ggc      395
 Cys Thr Ala Val Leu Glu Asn Leu Leu Phe Ser Ala Val Leu Leu Gly
              20                  25                  30

 tgg ggc tcg ctg ctc atc atg ctc aag tca gag ggc ttt tac tcc tac      443
 Trp Gly Ser Leu Leu Ile Met Leu Lys Ser Glu Gly Phe Tyr Ser Tyr
          35                  40                  45

 ctg tgt acc gag cca gag aat gtc acc aat ggc aca gtg ggc ggc aca      491
 Leu Cys Thr Glu Pro Glu Asn Val Thr Asn Gly Thr Val Gly Gly Thr
      50                  55                  60

 gca gag ccg ggg cac gag gag gtg agc tgg atg aac ggc tgg ctc agc      539
 Ala Glu Pro Gly His Glu Glu Val Ser Trp Met Asn Gly Trp Leu Ser
  65                  70                  75                  80

 tgc cag gcc cag gac gag atg cta aat ttg gcc ttc act gtg ggc tcc      587
 Cys Gln Ala Gln Asp Glu Met Leu Asn Leu Ala Phe Thr Val Gly Ser
                  85                  90                  95

 ttt ctg ctc agt gcc atc acc ctg ccc ctg ggt atc gtc atg gac aag      635
 Phe Leu Leu Ser Ala Ile Thr Leu Pro Leu Gly Ile Val Met Asp Lys
             100                 105                 110

 tat ggc ccg agg aag ctc agg ctg ctg ggc agc gcc tgc ttc gcg gtt      683
 Tyr Gly Pro Arg Lys Leu Arg Leu Leu Gly Ser Ala Cys Phe Ala Val
         115                 120                 125

 tcc tgc ttg ctg att gcg tac gga gca agt aaa cca aac gct ctc tcc      731
 Ser Cys Leu Leu Ile Ala Tyr Gly Ala Ser Lys Pro Asn Ala Leu Ser
     130                 135                 140

 gtg ctc atc ttc atc gcc ctg gct ctg aat ggc ttt ggt ggg atg tgt      779
 Val Leu Ile Phe Ile Ala Leu Ala Leu Asn Gly Phe Gly Gly Met Cys
 145                 150                 155                 160

 atg acc ttc acc tca tta aca ctg ccc aac atg ttc ggc gac ctt cgg      827
 Met Thr Phe Thr Ser Leu Thr Leu Pro Asn Met Phe Gly Asp Leu Arg
                 165                 170                 175

 tcc acg ttt att gcc ttg atg att ggg tcc tac gcc tcc tcg gca gtc      875
 Ser Thr Phe Ile Ala Leu Met Ile Gly Ser Tyr Ala Ser Ser Ala Val
             180                 185                 190

 acc ttt cca gga atc aag ctc atc tat gat gct ggt gtc tcc ttc atc      923
 Thr Phe Pro Gly Ile Lys Leu Ile Tyr Asp Ala Gly Val Ser Phe Ile
         195                 200                 205

 gtc gtc ctc gtg gtc tgg gcc ggc tgc tcc ggg ctg gtt ttc ctc aac      971
 Val Val Leu Val Val Trp Ala Gly Cys Ser Gly Leu Val Phe Leu Asn
     210                 215                 220

 tgc ttc ttt aac tgg ccc ctt gag ccc ttc ccg ggg ccg gag gac atg     1019
 Cys Phe Phe Asn Trp Pro Leu Glu Pro Phe Pro Gly Pro Glu Asp Met
 225                 230                 235                 240

 gac tac tcg gtg aag atc aag ttc agc tgg ctg ggc ttt gac cac aag     1067
 Asp Tyr Ser Val Lys Ile Lys Phe Ser Trp Leu Gly Phe Asp His Lys
                 245                 250                 255

 atc aca ggg aag cag ttc tac aag cag gtg acc acg gtg ggc cgg cgc     1115
 Ile Thr Gly Lys Gln Phe Tyr Lys Gln Val Thr Thr Val Gly Arg Arg
             260                 265                 270

 ctg agt gtg ggc agc tcc atg agg agt gcc aag gag cag gtg gcg ctg     1163
 Leu Ser Val Gly Ser Ser Met Arg Ser Ala Lys Glu Gln Val Ala Leu
         275                 280                 285

 cag gag ggc cac aag ctg tgc ctg tcc acc gtc gac ctg gag gtg aag     1211
 Gln Glu Gly His Lys Leu Cys Leu Ser Thr Val Asp Leu Glu Val Lys
     290                 295                 300

 tgc cag ccg gat gcc gca gtg gcc ccc tcc ttc atg cac agc gtg ttc     1259
 Cys Gln Pro Asp Ala Ala Val Ala Pro Ser Phe Met His Ser Val Phe
 305                 310                 315                 320

 agc ccc atc ctg ctg ctc agc ctg gtc acc atg tgc gtc acg cag ctg     1307
 Ser Pro Ile Leu Leu Leu Ser Leu Val Thr Met Cys Val Thr Gln Leu
                 325                 330                 335

 cgg ctc atc ttc tac atg ggg gct atg aac aac atc ctc aag ttc ctg     1355
 Arg Leu Ile Phe Tyr Met Gly Ala Met Asn Asn Ile Leu Lys Phe Leu
             340                 345                 350

 gtc agc ggc gac cag aag aca gtt ggc ctc tac acc tcc atc ttc ggc     1403
 Val Ser Gly Asp Gln Lys Thr Val Gly Leu Tyr Thr Ser Ile Phe Gly
         355                 360                 365

 gtg ctc cag ctg ctg tgc ctg ctg acg gcc ccc gtc att ggc tac atc     1451
 Val Leu Gln Leu Leu Cys Leu Leu Thr Ala Pro Val Ile Gly Tyr Ile
     370                 375                 380

 atg gac tgg agg ctg aag gag tgt gaa gac gcc tcc gag gag ccc gag     1499
 Met Asp Trp Arg Leu Lys Glu Cys Glu Asp Ala Ser Glu Glu Pro Glu
 385                 390                 395                 400

 gag aaa gac gcc aac caa ggc gag aag aaa aag aag aag cgg gac cgg     1547
 Glu Lys Asp Ala Asn Gln Gly Glu Lys Lys Lys Lys Lys Arg Asp Arg
                 405                 410                 415

 cag atc cag aag atc act aat gcc atg cgg gcc ttc gcc ttc acc aac     1595
 Gln Ile Gln Lys Ile Thr Asn Ala Met Arg Ala Phe Ala Phe Thr Asn
             420                 425                 430

 ctg ctg ctc gtg ggc ttt ggg gtg acc tgc ctc att ccc aac ctg cct     1643
 Leu Leu Leu Val Gly Phe Gly Val Thr Cys Leu Ile Pro Asn Leu Pro
         435                 440                 445

 ctc cag atc ctc tcc ttc atc ctg cac aca atc gtg cga gga ttc atc     1691
 Leu Gln Ile Leu Ser Phe Ile Leu His Thr Ile Val Arg Gly Phe Ile
     450                 455                 460

 cac tcc gct gtc ggg ggc ctg tac gct gcc gtg tac ccc tcc acc cag     1739
 His Ser Ala Val Gly Gly Leu Tyr Ala Ala Val Tyr Pro Ser Thr Gln
 465                 470                 475                 480

 ttc ggc agc ctc acg gga ctg cag tct ctg atc agc gcg ctc ttc gcc     1787
 Phe Gly Ser Leu Thr Gly Leu Gln Ser Leu Ile Ser Ala Leu Phe Ala
                 485                 490                 495

 ctt ctg cag cag ccg ctg ttt ctg gcc atg atg ggt cct ctc cag gga     1835
 Leu Leu Gln Gln Pro Leu Phe Leu Ala Met Met Gly Pro Leu Gln Gly
             500                 505                 510

 gac cct ctg tgg gtg aac gtg ggg ctg ctc ctt ctc agc ctg ctg ggc     1883
 Asp Pro Leu Trp Val Asn Val Gly Leu Leu Leu Leu Ser Leu Leu Gly
         515                 520                 525

 ttc tgc ctc ccg ctc tac ctg atc tgc tac cgg cgc cag ctg gag cgg     1931
 Phe Cys Leu Pro Leu Tyr Leu Ile Cys Tyr Arg Arg Gln Leu Glu Arg
     530                 535                 540

 cag ctg cag cag agg cag gag gat gac aaa ctc ttc ctc aaa atc aac     1979
 Gln Leu Gln Gln Arg Gln Glu Asp Asp Lys Leu Phe Leu Lys Ile Asn
 545                 550                 555                 560

 ggc tcg tcc aac cag gag gcc ttc gtg tag t ggctgccgcc tcggaactgc     2030
 Gly Ser Ser Asn Gln Glu Ala Phe Val 
                 565

 ggtctcctgc ctgtgcttca gtgactgacc cctgtcctgc ccctccagag taccccacgc   2090

 acccccagga ccttcgccgt ctccgtgcca gcgttcacgc tccctcccgg ggccctgcct   2150

 cggagctctg tggtggaagg acgggagagg gccccggaca cgcgcgtttt ctcctgccga   2210

 acgcaggggc tgccctgact ttgctctgcc gccccccggg gacccggggc ctggggtctc   2270

 tgtggtgcct gcagcaggag ccaggaacgc ccggcaggca ggcgctctcc cgccagtgtc   2330

 tggattctgc ctcttgccaa agcagagggg gctgccatcc cctgcctgcc acctgcccct   2390

 cggctgcatg cccacagccg tacctgcctg aggacaaagg cttgcactgt ctcgcccgcg   2450

 cctggccccc accccctccc cggccagcct gaggctgcct gaggaaggaa ggacccgctt   2510

 cctgttgtcg gtgctaattc ctttgtaatt ccagccccct gtcgcctgtc cagggcctgc   2570

 ccacccgttg gaggccggtg gagaagcccc acctggctta tgccctggag agggtttagc   2630

 gggctgggtg gacccctcgc ctcctccccg agggccaatg ccgcggacac gttttcactg   2690

 tcaccctcgt tctgtctgcc acctgaaggg aatttgagga ccgccgccag ggcaccccgt   2750

 acatacacac agctgctttt gtggaggtgg acgaaaggct gtggccggca gacgtggagg   2810

 tccaggccgg ggtggggacg tgggtgggtc cgaggggtgt gtggggtcgg ggtgggctct   2870

 aggagttagc ccttatcccc actgaccagg cgggagccgc caggcctgca gctgggccag   2930

 tgcccaggag ccatcctggc gtggggccag gagcttgtcc aaggccacag gcccacagca   2990

 ccccctgccg gcgggctccg tggggccctg gagctgatga cgggggaggc ccgtccgcct   3050

 ggcccaccaa cccgcccacc ttgactgccc ccagaagtgt gtcttgagac ctcctgggcg   3110

 tgcttagagg ggtgagttgt gtttggattt ttagttattt tctcttcagt tttattagac   3170

 ttctttttta taaagcaata aatccatttt cctccgggta aaaaaaaaaa aaaaa        3225




      <210> 153
      <211> 733
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (249)..(626)

      <400> 153
 ttgaacgcct gcggcaccgg tccggaattc ccgggtcgac ccacgcgtcc ggctacgcag     60

 ccttcggtgc agtcgtcact cgtgtctcgc taccagctcc ccgctgccct gcgctcggcg    120

 ggctggcatc cggcccgggg gaaagcggac cagcccttct gcaggtctgc ggggccaagt    180

 gtcccggcgg cgcacctcgt ggcgagaatc gggagaagga ggagactaca aggataggcc    240

 caggagta atg gag tcc aaa gag aaa cga gca gta aac agt ctc agc atg     290
          Met Glu Ser Lys Glu Lys Arg Ala Val Asn Ser Leu Ser Met
            1               5                  10

 gaa aat gcc aac caa gaa aat gaa gaa aag gag caa gtt gct aat aaa      338
 Glu Asn Ala Asn Gln Glu Asn Glu Glu Lys Glu Gln Val Ala Asn Lys
  15                  20                  25                  30

 ggg gag ccc ttg gcc ctc cct ttg gat gct ggt gaa tac tgt gtg cct      386
 Gly Glu Pro Leu Ala Leu Pro Leu Asp Ala Gly Glu Tyr Cys Val Pro
                  35                  40                  45

 aga gga aat cgt agg cgg ttc cgc gtt agg cag ccc atc ctg cag tat      434
 Arg Gly Asn Arg Arg Arg Phe Arg Val Arg Gln Pro Ile Leu Gln Tyr
              50                  55                  60

 aga tgg gat atg atg cat agg ctt gga gaa cca cag gca agg atg aga      482
 Arg Trp Asp Met Met His Arg Leu Gly Glu Pro Gln Ala Arg Met Arg
          65                  70                  75

 gaa gag aat atg gaa agg att ggg gag gag gtg aga cag ctg atg gaa      530
 Glu Glu Asn Met Glu Arg Ile Gly Glu Glu Val Arg Gln Leu Met Glu
      80                  85                  90

 aag ctg agg gaa aag cag ttg agt cat agt ctg cgg gca gtc agc act      578
 Lys Leu Arg Glu Lys Gln Leu Ser His Ser Leu Arg Ala Val Ser Thr
  95                 100                 105                 110

 gac ccc cct cac cat gac cat cat gat gag ttt tgc ctt atg ccc tga      626
 Asp Pro Pro His His Asp His His Asp Glu Phe Cys Leu Met Pro 
                 115                 120                 125

 atcctgatgg tttccctaaa gttttacgga aacagacccc tgctttcgaa tttacatgtt    686

 catgatgtgc ccttgttgta aaccttacct gtcacttgtt taggtgg                  733




      <210> 154
      <211> 2204
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (186)..(2054)

      <400> 154
 cagtggtaac aacgcagagt agcggggggg gtggaggtca gcagtgccac agaacaaact     60

 ggagttaaga aatgtcgttc ttcagattta aaaagaaaac ctttactgaa tcagctgagt    120

 gttaataata cgaatttcct tttcttgcca attctgatct gaacagaaaa tccaagaaca    180

 gggat    atg tgt gga tta cag ttt tct ctg cct tgc cta cga ctg ttt     227
          Met Cys Gly Leu Gln Phe Ser Leu Pro Cys Leu Arg Leu Phe
            1               5                  10

 ctg gtt gtt acc tgt tat ctt tta tta tta ctc cac aaa gaa ata ctt      275
 Leu Val Val Thr Cys Tyr Leu Leu Leu Leu Leu His Lys Glu Ile Leu
  15                  20                  25                  30

 gga tgt tcg tct gtt tgt cag ctc tgc act ggg aga caa att aac tgc      323
 Gly Cys Ser Ser Val Cys Gln Leu Cys Thr Gly Arg Gln Ile Asn Cys
                  35                  40                  45

 cgt aac tta ggc ctt tcg agt att cct aag aat ttt cct gaa agt aca      371
 Arg Asn Leu Gly Leu Ser Ser Ile Pro Lys Asn Phe Pro Glu Ser Thr
              50                  55                  60

 gtt ttt ctg tat ctg act ggg aat aat ata tct tat ata aat gaa agt      419
 Val Phe Leu Tyr Leu Thr Gly Asn Asn Ile Ser Tyr Ile Asn Glu Ser
          65                  70                  75

 gaa tta aca gga ctt cat tct ctt gta gca ttg tat ttg gat aat tct      467
 Glu Leu Thr Gly Leu His Ser Leu Val Ala Leu Tyr Leu Asp Asn Ser
      80                  85                  90

 aac att ctg tat gta tat cca aaa gcc ttt gtt caa ttg agg cat cta      515
 Asn Ile Leu Tyr Val Tyr Pro Lys Ala Phe Val Gln Leu Arg His Leu
  95                 100                 105                 110

 tat ttt cta ttt cta aat aat aat ttc atc aaa cgc tta gat cct gga      563
 Tyr Phe Leu Phe Leu Asn Asn Asn Phe Ile Lys Arg Leu Asp Pro Gly
                 115                 120                 125

 ata ttt aag gga ctt tta aat ctt cgt aat tta tat tta cag tat aat      611
 Ile Phe Lys Gly Leu Leu Asn Leu Arg Asn Leu Tyr Leu Gln Tyr Asn
             130                 135                 140

 cag gta tct ttt gtt ccg aga gga gta ttt aat gat cta gtt tca gtt      659
 Gln Val Ser Phe Val Pro Arg Gly Val Phe Asn Asp Leu Val Ser Val
         145                 150                 155

 cag tac tta aat cta caa agg aat cgc ctc act gtc ctt ggg agt ggt      707
 Gln Tyr Leu Asn Leu Gln Arg Asn Arg Leu Thr Val Leu Gly Ser Gly
     160                 165                 170

 acc ttt gtt ggt atg gtt gct ctt cgg ata ctt gat tta tca aac aat      755
 Thr Phe Val Gly Met Val Ala Leu Arg Ile Leu Asp Leu Ser Asn Asn
 175                 180                 185                 190

 aac att ttg agg ata tca gaa tca ggc ttt caa cat ctt gaa aac ctt      803
 Asn Ile Leu Arg Ile Ser Glu Ser Gly Phe Gln His Leu Glu Asn Leu
                 195                 200                 205

 gct tgt ttg tat tta gga agt aat aat tta aca aaa gta cca tca aat      851
 Ala Cys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Lys Val Pro Ser Asn
             210                 215                 220

 gcc ttt gaa gta ctt aaa agt ctt aga aga ctt tct ttg tct cat aat      899
 Ala Phe Glu Val Leu Lys Ser Leu Arg Arg Leu Ser Leu Ser His Asn
         225                 230                 235

 cct att gaa gca ata cag ccc ttt gca ttt aaa gga ctt gcc aat ctg      947
 Pro Ile Glu Ala Ile Gln Pro Phe Ala Phe Lys Gly Leu Ala Asn Leu
     240                 245                 250

 gaa tac ctc ctc ctg aaa aat tca aga att agg aat gtt act agg gat      995
 Glu Tyr Leu Leu Leu Lys Asn Ser Arg Ile Arg Asn Val Thr Arg Asp
 255                 260                 265                 270

 ggg ttt agt gga att aat aat ctt aaa cat ttg atc tta agt cat aat     1043
 Gly Phe Ser Gly Ile Asn Asn Leu Lys His Leu Ile Leu Ser His Asn
                 275                 280                 285

 gat tta gag aat tta aat tct gac aca ttc agt ttg tta aag aat tta     1091
 Asp Leu Glu Asn Leu Asn Ser Asp Thr Phe Ser Leu Leu Lys Asn Leu
             290                 295                 300

 att tac ctt aag tta gat aga aac aga ata att agc att gat aat gat     1139
 Ile Tyr Leu Lys Leu Asp Arg Asn Arg Ile Ile Ser Ile Asp Asn Asp
         305                 310                 315

 aca ttt gaa aat atg gga gca tct ttg aag atc ctt aat ctg tca ttt     1187
 Thr Phe Glu Asn Met Gly Ala Ser Leu Lys Ile Leu Asn Leu Ser Phe
     320                 325                 330

 aat aat ctt aca gcc ttg cat cca agg gtc ctt aag ccg ttg tct tca     1235
 Asn Asn Leu Thr Ala Leu His Pro Arg Val Leu Lys Pro Leu Ser Ser
 335                 340                 345                 350

 ttg att cat ctt cag gca aat tct aat cct tgg gaa tgt aac tgc aaa     1283
 Leu Ile His Leu Gln Ala Asn Ser Asn Pro Trp Glu Cys Asn Cys Lys
                 355                 360                 365

 ctt ttg ggc ctt cga gac tgg cta gca tct tca gcc att act cta aac     1331
 Leu Leu Gly Leu Arg Asp Trp Leu Ala Ser Ser Ala Ile Thr Leu Asn
             370                 375                 380

 atc tat tgt cag aat ccc cca tcc atg cgt ggc aga gca tta cgt tat     1379
 Ile Tyr Cys Gln Asn Pro Pro Ser Met Arg Gly Arg Ala Leu Arg Tyr
         385                 390                 395

 att aac att aca aat tgt gtt aca tct tca ata aat gta tcc aga gct     1427
 Ile Asn Ile Thr Asn Cys Val Thr Ser Ser Ile Asn Val Ser Arg Ala
     400                 405                 410

 tgg gct gtt gta aaa tct cct cat att cat cac aag act act gcg cta     1475
 Trp Ala Val Val Lys Ser Pro His Ile His His Lys Thr Thr Ala Leu
 415                 420                 425                 430

 atg atg gcc tgg cat aaa gta acc aca aat ggc agt cct ctg gaa aat     1523
 Met Met Ala Trp His Lys Val Thr Thr Asn Gly Ser Pro Leu Glu Asn
                 435                 440                 445

 act gag act gag aac att act ttc tgg gaa cga att cct act tca cct     1571
 Thr Glu Thr Glu Asn Ile Thr Phe Trp Glu Arg Ile Pro Thr Ser Pro
             450                 455                 460

 gct ggt aga ttt ttt caa gag aat gcc ttt ggt aat cca tta gag act     1619
 Ala Gly Arg Phe Phe Gln Glu Asn Ala Phe Gly Asn Pro Leu Glu Thr
         465                 470                 475

 aca gca gtg tta cct gtg caa ata caa ctt act act tct gtt acc ttg     1667
 Thr Ala Val Leu Pro Val Gln Ile Gln Leu Thr Thr Ser Val Thr Leu
     480                 485                 490

 aac ttg gaa aaa aac agt gct cta ccg aat gat gct gct tca atg tca     1715
 Asn Leu Glu Lys Asn Ser Ala Leu Pro Asn Asp Ala Ala Ser Met Ser
 495                 500                 505                 510

 ggg aaa aca tct cta att tgt aca caa gaa gtt gag aag ttg aat gag     1763
 Gly Lys Thr Ser Leu Ile Cys Thr Gln Glu Val Glu Lys Leu Asn Glu
                 515                 520                 525

 gct ttt gac att ttg cta gct ttt ttc atc tta gct tgt gtt tta atc     1811
 Ala Phe Asp Ile Leu Leu Ala Phe Phe Ile Leu Ala Cys Val Leu Ile
             530                 535                 540

 att ttt ttg atc tac aaa gtt gtt cag ttt aaa caa aaa cta aag gca     1859
 Ile Phe Leu Ile Tyr Lys Val Val Gln Phe Lys Gln Lys Leu Lys Ala
         545                 550                 555

 tca gaa aac tca agg gaa aat aga ctt gaa tac tac agc ttt tat cag     1907
 Ser Glu Asn Ser Arg Glu Asn Arg Leu Glu Tyr Tyr Ser Phe Tyr Gln
     560                 565                 570

 tca gca agg tat aat gta act gcc tca att tgt aac act tcc cca aat     1955
 Ser Ala Arg Tyr Asn Val Thr Ala Ser Ile Cys Asn Thr Ser Pro Asn
 575                 580                 585                 590

 tct cta gaa agt cct ggc ttg gag cag att cga ctt cat aaa caa att     2003
 Ser Leu Glu Ser Pro Gly Leu Glu Gln Ile Arg Leu His Lys Gln Ile
                 595                 600                 605

 gtt cct gaa aat gag gca cag gtc att ctt ttt gaa cat tct gct tta     2051
 Val Pro Glu Asn Glu Ala Gln Val Ile Leu Phe Glu His Ser Ala Leu
             610                 615                 620

 taa ctca actaaatatt gtctataaga aacttcagtg ccatggacat gatttaaact     2108
 


 gaaacctcct tatataatta tatactttag ttggaaatat aatgaattat atgaggttag   2168

 cattattaaa atatgttttt aataaaaaaa aaaaaa                             2204




      <210> 155
      <211> 1262
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (350)..(715)

      <400> 155
 cgcgcttcct gtgaggtcag gtgggaggaa accgcctgga gccgccggga gtggacgccg     60

 ccgaggcccg gagtcgcgcc tgcagacaca gcatctactc agcgtgggtc acctctgtga    120

 acatcactga ctgcaagcct ccctcaattt ctggtaaatt ttttccttca agctttttga    180

 ggtcaggggg aaaatcctcc acagatcttc acgagtctgg tcccagatca ctaacagcta    240

 aaggttttgt ggtggggaga acttctgtgc cacttggctt ccattagcct gcccaccctg    300

 accacacaat gcaggtgcag cccatcaggg acccacagcg cctgggagg    atg gtg     355
                                                          Met Val
                                                            1

 cgg atc ttg gcc aat ggg gaa atc gtg cag gat gac gac ccc cga gtg      403
 Arg Ile Leu Ala Asn Gly Glu Ile Val Gln Asp Asp Asp Pro Arg Val
           5                  10                  15

 agg acc act acc cag cca cca aga ggt agc att cct cga cag agc ttc      451
 Arg Thr Thr Thr Gln Pro Pro Arg Gly Ser Ile Pro Arg Gln Ser Phe
      20                  25                  30

 ttc aac agg ggc cat ggt gct ccc cca ggg ggt cct ggc ccc cgc cag      499
 Phe Asn Arg Gly His Gly Ala Pro Pro Gly Gly Pro Gly Pro Arg Gln
  35                  40                  45                  50

 cag cag gca ggt gcc agg ctg ggt gct gct cag tcc ccc ttc aat gac      547
 Gln Gln Ala Gly Ala Arg Leu Gly Ala Ala Gln Ser Pro Phe Asn Asp
                  55                  60                  65

 ctc aac cgg cag ctg gtg aac atg ggc ttt ccg cag tgg cat ctt ggc      595
 Leu Asn Arg Gln Leu Val Asn Met Gly Phe Pro Gln Trp His Leu Gly
              70                  75                  80

 aac cat gct gtg gag ccg gtg acc tcc atc ctg ctc ctc ttc ctg ctc      643
 Asn His Ala Val Glu Pro Val Thr Ser Ile Leu Leu Leu Phe Leu Leu
          85                  90                  95

 atg atg ctt ggt gtt cgt ggc ctc ctc ctg gtt ggc ctt gtc tac ctg      691
 Met Met Leu Gly Val Arg Gly Leu Leu Leu Val Gly Leu Val Tyr Leu
     100                 105                 110

 gtg tcc cac ctg agt cag cgg tga cctctgaggg ctgatagggg tgggtttgtt     745
 Val Ser His Leu Ser Gln Arg 
 115                 120

 gagagggact tgctgggcct tggtgtgaga gcaggcatat ttggagggga tctggtggtg    805

 ccttgaaggt atgatcagag aggggaccac aggtgtgtgt ttcccctttg tgttaagcgt    865

 gaggcagagg gagacgttag tccagcattt ccaaagtgtg ggtgggtccg ttggttcccg    925

 agatactttt aggtggtatg gggcctgcat taagtggcac aaaatcagag caagaaagcg    985

 atgcccttcc caattctctc aatcctttta tgccgagaag atctcagctg gatgccaaca   1045

 tgttccgatg cctgtggaag acatgccgac gtctcctctg cctagggagc aggacttggg   1105

 cttagggcag gtggaaaaaa ttccagactt ttttagcact gtttttgttt taatggtata   1165

 tttttattgg ctactttatt gtttaggaca agtggtagtg gcattctatt tattgtgacc   1225

 ttttcaataa atagatttaa gtaaaaaaaa aaaaaaa                            1262




      <210> 156
      <211> 1422
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1422)

      <400> 156
  atg ccc agc att ttt ggg gtc aaa aac aaa ggg gac ggg aaa agc tcg      48
  Met Pro Ser Ile Phe Gly Val Lys Asn Lys Gly Asp Gly Lys Ser Ser
    1               5                  10                  15

 ggt ccg acg ggg ctg gtg agg agc agg acc cac gac gga ctt gcc gag       96
 Gly Pro Thr Gly Leu Val Arg Ser Arg Thr His Asp Gly Leu Ala Glu
              20                  25                  30

 gtg ctg gtg ctg gag agc ggc agg aag gag gag ccg cgc ggc ggg ggc      144
 Val Leu Val Leu Glu Ser Gly Arg Lys Glu Glu Pro Arg Gly Gly Gly
          35                  40                  45

 gac agc ggc ggg ggc ggc ggg ggg cgg ccg aac ccg ggg ccc ccc aga      192
 Asp Ser Gly Gly Gly Gly Gly Gly Arg Pro Asn Pro Gly Pro Pro Arg
      50                  55                  60

 gcc gca ggg ccc ggc ggg ggc tcc ctc gcc agc agc tcg gtg gcc aag      240
 Ala Ala Gly Pro Gly Gly Gly Ser Leu Ala Ser Ser Ser Val Ala Lys
  65                  70                  75                  80

 tcg cac agc ttc ttc tcg ctg ctg aag aag aac ggg cgc tcg gaa aac      288
 Ser His Ser Phe Phe Ser Leu Leu Lys Lys Asn Gly Arg Ser Glu Asn
                  85                  90                  95

 ggc aag gga gag cct gtg gac gcg agc aag gcc ggc ggc aaa caa aag      336
 Gly Lys Gly Glu Pro Val Asp Ala Ser Lys Ala Gly Gly Lys Gln Lys
             100                 105                 110

 cgg ggg ctg cgg ggg ctg ttc agc ggc atg cgc tgg cac agg aaa gac      384
 Arg Gly Leu Arg Gly Leu Phe Ser Gly Met Arg Trp His Arg Lys Asp
         115                 120                 125

 aag cgg gcc aag gcg gag gcc gcg gag ggg cgc gcg ccc ggg ggc ggc      432
 Lys Arg Ala Lys Ala Glu Ala Ala Glu Gly Arg Ala Pro Gly Gly Gly
     130                 135                 140

 ttg atc cta ccc ggc tcg ctc acc gcc agc ctg gag tgc gtc aag gag      480
 Leu Ile Leu Pro Gly Ser Leu Thr Ala Ser Leu Glu Cys Val Lys Glu
 145                 150                 155                 160

 gag acg ccc aga gcc gcg cgc gag ccg gag gag ccc agc cag gac gcc      528
 Glu Thr Pro Arg Ala Ala Arg Glu Pro Glu Glu Pro Ser Gln Asp Ala
                 165                 170                 175

 ccg cga gac cca gca ggc tgt gga gat att att gca gac caa gag gaa      576
 Pro Arg Asp Pro Ala Gly Cys Gly Asp Ile Ile Ala Asp Gln Glu Glu
             180                 185                 190

 gag gca ggt ccc agc tgt gac aag cat gtc ccc ggg cca ggc aag ccg      624
 Glu Ala Gly Pro Ser Cys Asp Lys His Val Pro Gly Pro Gly Lys Pro
         195                 200                 205

 gct ctg tct aaa aag aac ccc ggc gtg gtg gcc tac caa gga ggc ggg      672
 Ala Leu Ser Lys Lys Asn Pro Gly Val Val Ala Tyr Gln Gly Gly Gly
     210                 215                 220

 gaa gag atg gcc agc ccg gac gag gtg gac gac acc tat cta cag gag      720
 Glu Glu Met Ala Ser Pro Asp Glu Val Asp Asp Thr Tyr Leu Gln Glu
 225                 230                 235                 240

 ttc tgg gac atg ctc tcc cag acc gag gag cag gga ccc gag ccc cag      768
 Phe Trp Asp Met Leu Ser Gln Thr Glu Glu Gln Gly Pro Glu Pro Gln
                 245                 250                 255

 gag ggc gcg gct aag gtg gca gct gcg ctg gaa acc aag gtg gtg ccc      816
 Glu Gly Ala Ala Lys Val Ala Ala Ala Leu Glu Thr Lys Val Val Pro
             260                 265                 270

 gag acc ccc aaa gac acc agg tgt gtg gaa gcg gcc aag gac gcg tcc      864
 Glu Thr Pro Lys Asp Thr Arg Cys Val Glu Ala Ala Lys Asp Ala Ser
         275                 280                 285

 tcg gtc aag cgc agg agg ctc aac cgg att ccc atc gag ccc cat cct      912
 Ser Val Lys Arg Arg Arg Leu Asn Arg Ile Pro Ile Glu Pro His Pro
     290                 295                 300

 aag gag gag ccc aag cac ccg gag aag gag cag cag gaa ggc gtc ccc      960
 Lys Glu Glu Pro Lys His Pro Glu Lys Glu Gln Gln Glu Gly Val Pro
 305                 310                 315                 320

 aac agc gac gag ggc tac tgg gac tcc acc acg cca ggc cca gag gaa     1008
 Asn Ser Asp Glu Gly Tyr Trp Asp Ser Thr Thr Pro Gly Pro Glu Glu
                 325                 330                 335

 gac agc tcg agc agc ggg aag aag gcg ggc atc ccc cgg gat agc tac     1056
 Asp Ser Ser Ser Ser Gly Lys Lys Ala Gly Ile Pro Arg Asp Ser Tyr
             340                 345                 350

 agc ggg gac gcg ctc tat gat ctc tat gct gac ccg gac gga agt cca     1104
 Ser Gly Asp Ala Leu Tyr Asp Leu Tyr Ala Asp Pro Asp Gly Ser Pro
         355                 360                 365

 gca acc ctt cct gga ggg aag gac aac gag gag acg tcc tcc ctg tcc     1152
 Ala Thr Leu Pro Gly Gly Lys Asp Asn Glu Glu Thr Ser Ser Leu Ser
     370                 375                 380

 cgg tta aag ccc gta tct cca ggc acc atc acc tgt cca ctg cga aca     1200
 Arg Leu Lys Pro Val Ser Pro Gly Thr Ile Thr Cys Pro Leu Arg Thr
 385                 390                 395                 400

 cca ggc agc ttg ctg aag gac tct aag atc cct att agc atc aag cac     1248
 Pro Gly Ser Leu Leu Lys Asp Ser Lys Ile Pro Ile Ser Ile Lys His
                 405                 410                 415

 ctg acc aac ctt cca tct agc cat ccc gtg gtg cac cag caa ccc tcc     1296
 Leu Thr Asn Leu Pro Ser Ser His Pro Val Val His Gln Gln Pro Ser
             420                 425                 430

 agg agt gag atg ccc aga aca aaa atc ccg gtt tcc aaa gtg ctg gtc     1344
 Arg Ser Glu Met Pro Arg Thr Lys Ile Pro Val Ser Lys Val Leu Val
         435                 440                 445

 cgc aga gtc agc aac cgg ggc ttg gct ggg acc acc atc aga gca acg     1392
 Arg Arg Val Ser Asn Arg Gly Leu Ala Gly Thr Thr Ile Arg Ala Thr
     450                 455                 460

 gcc tgc cac gac agt gcc aaa aag ttg tga                             1422
 Ala Cys His Asp Ser Ala Lys Lys Leu 
 465                 470





      <210> 157
      <211> 3219
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (634)..(2709)

      <400> 157
 ggacgcggcc ggcggggcgg acgggagcgg gccgcgcgtg gcggcggcga tgggcgaggg     60

 cgggctgccc ccggccttcc agctgctgct gcgcgcgtgt gaccaggcga cacggagacg    120

 gcgcggcggc tgctggagcc gggggcggcg gagccagccg agcgcggcgc ggagccggag    180

 gcgggcgcgg agccggcggg ggccgaggtg gctgggcccg gggccgcagc ggcgggggca    240

 gtcggggctc cggtgcccgt ggattgctcg gacgaggcgg gcaacaccgc actgcagttc    300

 gccgcggccg ggggccacga accgctggtg cgcttcctgc tgcgccgcgg tgcctcggtc    360

 aacagccgca accactatgg ctggagcgcg ctcatgcagg cggccagatt tgggcatgtg    420

 agtgtggcac acctcctgtt ggatcacggg gctgatgtca atgcccagaa ccggctgggg    480

 gccagtgtgc tcactgtggc ttctcggggc ggccacctgg gtgtggtgaa gctgctcctg    540

 gaagccggtg cctttgtgga ccatcaccac ccttcaggcg agcaactggg gttgggcggc    600

 agcagggatg agcccttgga catcacagcc ctg atg gct gcc atc cag cac ggg     654
                                      Met Ala Ala Ile Gln His Gly
                                        1               5

 cac gag gcc gtg gtg cgt cta ctg atg gag tgg ggc gcg gac ccc aac      702
 His Glu Ala Val Val Arg Leu Leu Met Glu Trp Gly Ala Asp Pro Asn
          10                  15                  20

 cac gca gcc cgg acc gtg ggc tgg agc ccg ctg atg ctg gcc gca ctc      750
 His Ala Ala Arg Thr Val Gly Trp Ser Pro Leu Met Leu Ala Ala Leu
      25                  30                  35

 act ggg cgg ctt gga gtg gcc cag cag ctg gtg gag aag ggc gcc aac      798
 Thr Gly Arg Leu Gly Val Ala Gln Gln Leu Val Glu Lys Gly Ala Asn
  40                  45                  50                  55

 cct gac cac ctc agc gtg ctg gag aag acc gcc ttc gag gtt gca ctg      846
 Pro Asp His Leu Ser Val Leu Glu Lys Thr Ala Phe Glu Val Ala Leu
                  60                  65                  70

 gac tgc aag cac agg gac ctt gta gac tac ctg gac ccg ctg acc acc      894
 Asp Cys Lys His Arg Asp Leu Val Asp Tyr Leu Asp Pro Leu Thr Thr
              75                  80                  85

 gtc agg ccc aaa aca gat gag gag aaa agg cga cct gat att ttc cat      942
 Val Arg Pro Lys Thr Asp Glu Glu Lys Arg Arg Pro Asp Ile Phe His
          90                  95                 100

 gca ttg aaa atg gga aac ttc cag ctg gtc aaa gag att gcc gat gaa      990
 Ala Leu Lys Met Gly Asn Phe Gln Leu Val Lys Glu Ile Ala Asp Glu
     105                 110                 115

 gac ccc agc cac gtg aac ttg gtc aat ggg gac ggg gcg acg cca ctg     1038
 Asp Pro Ser His Val Asn Leu Val Asn Gly Asp Gly Ala Thr Pro Leu
 120                 125                 130                 135

 atg cta gca gct gtt acg ggg cag ctg gct ctg gtg cag ctg ctg gtg     1086
 Met Leu Ala Ala Val Thr Gly Gln Leu Ala Leu Val Gln Leu Leu Val
                 140                 145                 150

 gag agg cac gcg gat gtt gac aag cag gac agc gtg cat ggc tgg acg     1134
 Glu Arg His Ala Asp Val Asp Lys Gln Asp Ser Val His Gly Trp Thr
             155                 160                 165

 gcc ctc atg cag gca acc tac cat ggg aat aag gaa att gtg aaa tat     1182
 Ala Leu Met Gln Ala Thr Tyr His Gly Asn Lys Glu Ile Val Lys Tyr
         170                 175                 180

 ctg cta aac caa ggg gcc gat gtc act ctt cgt gca aaa aat gga tac     1230
 Leu Leu Asn Gln Gly Ala Asp Val Thr Leu Arg Ala Lys Asn Gly Tyr
     185                 190                 195

 acg gcc ttt gac ctg gtg atg ctg ctg aat gat ccc gac acg gaa ctt     1278
 Thr Ala Phe Asp Leu Val Met Leu Leu Asn Asp Pro Asp Thr Glu Leu
 200                 205                 210                 215

 gtt cga ctg ctg gca tct gtc tgc atg cag gtg aat aaa gac aaa ggc     1326
 Val Arg Leu Leu Ala Ser Val Cys Met Gln Val Asn Lys Asp Lys Gly
                 220                 225                 230

 cgg ccg agc cac cag cct ccc ctg ccc cac tcg aag gtc cga cag ccc     1374
 Arg Pro Ser His Gln Pro Pro Leu Pro His Ser Lys Val Arg Gln Pro
             235                 240                 245

 tgg agc atc cca gtg ctg ccc gat gac aag ggt gga ctg aag tcc tgg     1422
 Trp Ser Ile Pro Val Leu Pro Asp Asp Lys Gly Gly Leu Lys Ser Trp
         250                 255                 260

 tgg aac cga atg tcc aat cgg ttc cga aag ctc aaa ctg atg cag acg     1470
 Trp Asn Arg Met Ser Asn Arg Phe Arg Lys Leu Lys Leu Met Gln Thr
     265                 270                 275

 ctg ccc cgt ggg ctg tcc agc aac cag cct ttg cct ttc tct gac gag     1518
 Leu Pro Arg Gly Leu Ser Ser Asn Gln Pro Leu Pro Phe Ser Asp Glu
 280                 285                 290                 295

 cct gag cca gct ctg gac tcc aca atg agg gct gcc ccc cag gac aag     1566
 Pro Glu Pro Ala Leu Asp Ser Thr Met Arg Ala Ala Pro Gln Asp Lys
                 300                 305                 310

 aca agc cgc tct gca ctc cct gat gcg gcc cct gtg acc aaa gac aat     1614
 Thr Ser Arg Ser Ala Leu Pro Asp Ala Ala Pro Val Thr Lys Asp Asn
             315                 320                 325

 ggt cct ggg agc aca aga gga gaa aag gaa gac acg tta ttg aca acc     1662
 Gly Pro Gly Ser Thr Arg Gly Glu Lys Glu Asp Thr Leu Leu Thr Thr
         330                 335                 340

 atg ctt cga aac gga gct ccc ctc acc aga ctc ccg agt gac aag ctg     1710
 Met Leu Arg Asn Gly Ala Pro Leu Thr Arg Leu Pro Ser Asp Lys Leu
     345                 350                 355

 aaa gca gtc atc ccc cca ttc cta ccc cct tcc agt ttt gag ctg tgg     1758
 Lys Ala Val Ile Pro Pro Phe Leu Pro Pro Ser Ser Phe Glu Leu Trp
 360                 365                 370                 375

 agc tct gat cgg tcc cgg acg cgt cac aac ggg aag gca gac ccc atg     1806
 Ser Ser Asp Arg Ser Arg Thr Arg His Asn Gly Lys Ala Asp Pro Met
                 380                 385                 390

 aag act gcg ctg ccc cag aga gcc agc agg ggc cac ccc gtg ggc ggc     1854
 Lys Thr Ala Leu Pro Gln Arg Ala Ser Arg Gly His Pro Val Gly Gly
             395                 400                 405

 ggg ggc aca gac act aca ccc gtc agg cct gtt aaa ttt cca agc ctc     1902
 Gly Gly Thr Asp Thr Thr Pro Val Arg Pro Val Lys Phe Pro Ser Leu
         410                 415                 420

 ccc aga agc cca gcc tct tct gcc aat tct gga aac ttc aac cac tcg     1950
 Pro Arg Ser Pro Ala Ser Ser Ala Asn Ser Gly Asn Phe Asn His Ser
     425                 430                 435

 cct cat tca tcg ggc ggc tcc agt ggg ata ggt gtg agc cgg cac ggt     1998
 Pro His Ser Ser Gly Gly Ser Ser Gly Ile Gly Val Ser Arg His Gly
 440                 445                 450                 455

 ggg gag ctg ctt aac cgc tca ggt ggc agc ata gac aat gtc ttg tcc     2046
 Gly Glu Leu Leu Asn Arg Ser Gly Gly Ser Ile Asp Asn Val Leu Ser
                 460                 465                 470

 caa atc gct gcc cag agg aag aaa gca gcc gga tta ttg gag cag aaa     2094
 Gln Ile Ala Ala Gln Arg Lys Lys Ala Ala Gly Leu Leu Glu Gln Lys
             475                 480                 485

 ccc agc cat cgg tca agc cct gtg ggg cca gca ccg ggg tcc agc ccg     2142
 Pro Ser His Arg Ser Ser Pro Val Gly Pro Ala Pro Gly Ser Ser Pro
         490                 495                 500

 tct gag ctt cca gcc tcc cct gca ggt ggc agc gct cct gtt ggc aag     2190
 Ser Glu Leu Pro Ala Ser Pro Ala Gly Gly Ser Ala Pro Val Gly Lys
     505                 510                 515

 cag aaa ttg gag acc agc aaa agg cct cca tct gga act tcc act acc     2238
 Gln Lys Leu Glu Thr Ser Lys Arg Pro Pro Ser Gly Thr Ser Thr Thr
 520                 525                 530                 535

 tcc aag agc acc tct cca acc ctc acg ccc tcc ccc tca ccc aaa ggg     2286
 Ser Lys Ser Thr Ser Pro Thr Leu Thr Pro Ser Pro Ser Pro Lys Gly
                 540                 545                 550

 cac act gca gag tcc tca gtg tct tcc tcg tca tcc cat cgg cag tcc     2334
 His Thr Ala Glu Ser Ser Val Ser Ser Ser Ser Ser His Arg Gln Ser
             555                 560                 565

 aag agc agt ggg ggc tcc agc agt ggc acc atc aca gat gag gat gaa     2382
 Lys Ser Ser Gly Gly Ser Ser Ser Gly Thr Ile Thr Asp Glu Asp Glu
         570                 575                 580

 ctg act gga atc ctt aag aaa tta tca ctt gag aaa tat cag ccc att     2430
 Leu Thr Gly Ile Leu Lys Lys Leu Ser Leu Glu Lys Tyr Gln Pro Ile
     585                 590                 595

 ttt gag gaa caa gag gtg gac atg gaa gcg ttc ctc aca ctg act gac     2478
 Phe Glu Glu Gln Glu Val Asp Met Glu Ala Phe Leu Thr Leu Thr Asp
 600                 605                 610                 615

 ggt gac ttg aag gag ctg gga att aag aca gat ggg tcc agg cag cag     2526
 Gly Asp Leu Lys Glu Leu Gly Ile Lys Thr Asp Gly Ser Arg Gln Gln
                 620                 625                 630

 att ctg gca gcg att tct gaa ctg aac gca ggc aag gga cgc gag aga     2574
 Ile Leu Ala Ala Ile Ser Glu Leu Asn Ala Gly Lys Gly Arg Glu Arg
             635                 640                 645

 caa att tta cag gaa acc att cac aac ttt cac tct tcc ttt gag agc     2622
 Gln Ile Leu Gln Glu Thr Ile His Asn Phe His Ser Ser Phe Glu Ser
         650                 655                 660

 agt gcc agc aac acc agg gcc cct ggc aac agc ccc tcc atg gtt ggg     2670
 Ser Ala Ser Asn Thr Arg Ala Pro Gly Asn Ser Pro Ser Met Val Gly
     665                 670                 675

 tgg gtg agg cca gaa gaa act gcc tcc ggc aag agg tag cagccgctca      2719
 Trp Val Arg Pro Glu Glu Thr Ala Ser Gly Lys Arg 
 680                 685                 690

 ggtggctctg ctggcatcgg agcccacaga agtgaggagt ggccgatgga cctgccctcc   2779

 aaatgtgcct gactctgggt cttgctgtca ctggatttcc tggcatggca gacagaaaga   2839

 aagatagttt gaccaagtcg tagaagctga tccagcgggt aaaaaggggg cagggaactc   2899

 gtccctttta ttcttgcctc agagctgcct gaagacatgg gccaggccgg aggctggaca   2959

 actttggata acgctgacct gtacttccaa gtaaatgcct cctgaagagc ccgggaccct   3019

 tcctgggaga attctgcagc cagaatgaag gtgccatcag caggaggcac tgtgaagcac   3079

 catcctgtcg ctgtccttgt ccattcctag caagttaatc gtgtcttgtt aaccagcagt   3139

 tcctgttcaa cgtgtaaaga gacctgatgt tttccctaat aaagctgata acagaaaaaa   3199

 aaaaaaaaaa aaaaagatct                                               3219




      <210> 158
      <211> 1333
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (280)..(1326)

      <400> 158
 gagatccaca cagctcggac cggctggatc ttgctcagtc tctgtcagag gaagatccct     60

 tggaggaggc cccgcagcga catggaggga gctgctttgc tgaaagtctt tgtcctctgc    120

 atctggaacc aaaatcactt cccggaattg accaactggt agactcgcct agaggggaag    180

 cattgtgtcc tagttgaggc taacagtcag tatccagcct caacattcag cagaggcccc    240

 agatcagcgt ctgagccagg ccaacaatga ccaaggagg   atg gga tcc tgg gtg     294
                                              Met Gly Ser Trp Val
                                                1               5

 cag ctc atc aca agc gtc ggg gtg cag caa aac cat cca ggc tgg aca      342
 Gln Leu Ile Thr Ser Val Gly Val Gln Gln Asn His Pro Gly Trp Thr
                  10                  15                  20

 gtg gct gga cag ttc caa gaa aag aaa cgc ttc act gaa gaa gtc att      390
 Val Ala Gly Gln Phe Gln Glu Lys Lys Arg Phe Thr Glu Glu Val Ile
              25                  30                  35

 gaa tac ttc cag aag aaa gtt agc cca gtg cat ctg aaa atc ctg ctg      438
 Glu Tyr Phe Gln Lys Lys Val Ser Pro Val His Leu Lys Ile Leu Leu
          40                  45                  50

 act agc gat gaa gcc tgg aag aga ttc gtg cgt gtg gct gaa ttg ccc      486
 Thr Ser Asp Glu Ala Trp Lys Arg Phe Val Arg Val Ala Glu Leu Pro
      55                  60                  65

 agg gaa gaa gca gat gct ctc tat gaa gct ctg aag aat ctt aca cca      534
 Arg Glu Glu Ala Asp Ala Leu Tyr Glu Ala Leu Lys Asn Leu Thr Pro
  70                  75                  80                  85

 tat gtg gct att gag gac aaa gac atg cag caa aaa gaa cag cag ttt      582
 Tyr Val Ala Ile Glu Asp Lys Asp Met Gln Gln Lys Glu Gln Gln Phe
                  90                  95                 100

 agg gag tgg ttt ttg aaa gag ttt cct caa atc aga tgg aag att cag      630
 Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Ile Arg Trp Lys Ile Gln
             105                 110                 115

 gag tcc ata gaa agg ctt cgt gtc att gca aat gag att gaa aag gtc      678
 Glu Ser Ile Glu Arg Leu Arg Val Ile Ala Asn Glu Ile Glu Lys Val
         120                 125                 130

 cac aga ggc tgc gtc atc gcc aat gtg gtg tct ggc tcc act ggc atc      726
 His Arg Gly Cys Val Ile Ala Asn Val Val Ser Gly Ser Thr Gly Ile
     135                 140                 145

 ctg tct gtc att ggc gtt atg ttg gca cca ttt aca gca ggg ctg agc      774
 Leu Ser Val Ile Gly Val Met Leu Ala Pro Phe Thr Ala Gly Leu Ser
 150                 155                 160                 165

 ctg agc att act gca gct ggg gta ggg ctg gga ata gca tct gcc acg      822
 Leu Ser Ile Thr Ala Ala Gly Val Gly Leu Gly Ile Ala Ser Ala Thr
                 170                 175                 180

 gct ggg atc gcc tcc agc atc gtg gag aac aca tac aca agg tca gca      870
 Ala Gly Ile Ala Ser Ser Ile Val Glu Asn Thr Tyr Thr Arg Ser Ala
             185                 190                 195

 gaa ctc aca gcc agc agg ctg act gca acc agc act gac caa ttg gag      918
 Glu Leu Thr Ala Ser Arg Leu Thr Ala Thr Ser Thr Asp Gln Leu Glu
         200                 205                 210

 gca tta agg gac att ctg cgt gac atc aca ccc aat gtg ctt tct ttt      966
 Ala Leu Arg Asp Ile Leu Arg Asp Ile Thr Pro Asn Val Leu Ser Phe
     215                 220                 225

 gca ctt gat ttt gac gaa gcc aca aaa atg att gcg aat gat gtc cat     1014
 Ala Leu Asp Phe Asp Glu Ala Thr Lys Met Ile Ala Asn Asp Val His
 230                 235                 240                 245

 aca ctc agg aga tct aaa gcc act gtt gga cgc cct ttg att gct tgg     1062
 Thr Leu Arg Arg Ser Lys Ala Thr Val Gly Arg Pro Leu Ile Ala Trp
                 250                 255                 260

 cga tat gta cct ata aat gtt gtt gag aca ctg aga aca cgt ggg gcc     1110
 Arg Tyr Val Pro Ile Asn Val Val Glu Thr Leu Arg Thr Arg Gly Ala
             265                 270                 275

 ccc acc cgg ata gtg aga aaa gta gcc cgg aac ctg ggc aag gcc act     1158
 Pro Thr Arg Ile Val Arg Lys Val Ala Arg Asn Leu Gly Lys Ala Thr
         280                 285                 290

 tca ggt gtc ctt gtt gtg ctg gat gta gtc aac ctt gtg caa gac tca     1206
 Ser Gly Val Leu Val Val Leu Asp Val Val Asn Leu Val Gln Asp Ser
     295                 300                 305

 ctg gac ttg cac aag ggg gca aaa tcc gag tct gct gag tcg ctg agg     1254
 Leu Asp Leu His Lys Gly Ala Lys Ser Glu Ser Ala Glu Ser Leu Arg
 310                 315                 320                 325

 cag tgg gct cag gag ctg gag gag aat ctc aat gag ctc acc cat atc     1302
 Gln Trp Ala Gln Glu Leu Glu Glu Asn Leu Asn Glu Leu Thr His Ile
                 330                 335                 340

 cat cag agt cta aaa gca ggc tag gcccaat                             1333
 His Gln Ser Leu Lys Ala Gly 
             345





      <210> 159
      <211> 2105
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (181)..(1227)

      <220>
      <221> misc_feature
      <222> (1)...(2105)
      <223> n = a,t,c or g

      <400> 159
 gccaggagcc atgtgggttt ttctaggaac caaaatcact tcccggaatt gaccaactgg     60

 tagactcgcc tagaggggaa gcattgtgtc ctagttgagg ctaacagtca gtatccagcc    120

 tcaacattca gcagaggccc cagatcagcg tctgagccag gccaacaatg accaaggagg    180
                                                                 
 atg gga tcc tgg gtg cag ctc atc aca agc gtc ggg gtg cag caa aac      228
 Met Gly Ser Trp Val Gln Leu Ile Thr Ser Val Gly Val Gln Gln Asn
   1               5                  10                  15

 cat cca ggc tgg aca gtg gct gga cag ttc caa gaa aag aaa cgc ttc      276
 His Pro Gly Trp Thr Val Ala Gly Gln Phe Gln Glu Lys Lys Arg Phe
              20                  25                  30

 act gaa gaa gtc att gaa tac ttc cag aag aaa gtt agc cca gtg cat      324
 Thr Glu Glu Val Ile Glu Tyr Phe Gln Lys Lys Val Ser Pro Val His
          35                  40                  45

 ctg aaa atc ctg ctg act agc gat gaa gcc tgg aag aga ttc gtg cgt      372
 Leu Lys Ile Leu Leu Thr Ser Asp Glu Ala Trp Lys Arg Phe Val Arg
      50                  55                  60

 gtg gct gaa ttg ccc agg gaa gaa gca gat gct ctc tat gaa gct ctg      420
 Val Ala Glu Leu Pro Arg Glu Glu Ala Asp Ala Leu Tyr Glu Ala Leu
  65                  70                  75                  80

 aag aat ctt aca cca tat gtg gct att gag gac aaa gac atg cag caa      468
 Lys Asn Leu Thr Pro Tyr Val Ala Ile Glu Asp Lys Asp Met Gln Gln
                  85                  90                  95

 aaa gaa cag cag ttt agg gag tgg ttt ttg aaa gag ttt cct caa atc      516
 Lys Glu Gln Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Ile
             100                 105                 110

 aga tgg aag att cag gag tcc ata gaa agg ctt cgt gtc att gca aat      564
 Arg Trp Lys Ile Gln Glu Ser Ile Glu Arg Leu Arg Val Ile Ala Asn
         115                 120                 125

 gag att gaa aag gtc cac aga ggc tgc gtc atc gcc aat gtg gtg tct      612
 Glu Ile Glu Lys Val His Arg Gly Cys Val Ile Ala Asn Val Val Ser
     130                 135                 140

 ggc tcc act ggc atc ctg tct gtc att ggc gtt atg ttg gca cca ttt      660
 Gly Ser Thr Gly Ile Leu Ser Val Ile Gly Val Met Leu Ala Pro Phe
 145                 150                 155                 160

 aca gca ggg ctg agc ctg agc att act gca gct ggg gta ggg ctg gga      708
 Thr Ala Gly Leu Ser Leu Ser Ile Thr Ala Ala Gly Val Gly Leu Gly
                 165                 170                 175

 ata gca tct gcc acg gct ggg atc gcc tcc agc atc gtg gag aac aca      756
 Ile Ala Ser Ala Thr Ala Gly Ile Ala Ser Ser Ile Val Glu Asn Thr
             180                 185                 190

 tac aca agg tca gca gaa ctc aca gcc agc agg ctg act gca acc agc      804
 Tyr Thr Arg Ser Ala Glu Leu Thr Ala Ser Arg Leu Thr Ala Thr Ser
         195                 200                 205

 act gac caa ttg gag gca tta agg gac att ctg cat gac atc aca ccc      852
 Thr Asp Gln Leu Glu Ala Leu Arg Asp Ile Leu His Asp Ile Thr Pro
     210                 215                 220

 aat gtg ctt tcc ttt gca ctt gat ttt gac gaa gcc aca aaa atg att      900
 Asn Val Leu Ser Phe Ala Leu Asp Phe Asp Glu Ala Thr Lys Met Ile
 225                 230                 235                 240

 gcg aat gat gtc cat aca ctc agg aga tct aaa gcc act gtt gga cgc      948
 Ala Asn Asp Val His Thr Leu Arg Arg Ser Lys Ala Thr Val Gly Arg
                 245                 250                 255

 cct ttg att gct tgg cga tat gta cct ata aat gtt gtt gag aca ctg      996
 Pro Leu Ile Ala Trp Arg Tyr Val Pro Ile Asn Val Val Glu Thr Leu
             260                 265                 270

 aga aca cgt ggg gcc ccc acc cgg ata gtg aga aaa gta gcc cgg aac     1044
 Arg Thr Arg Gly Ala Pro Thr Arg Ile Val Arg Lys Val Ala Arg Asn
         275                 280                 285

 ctg ggc aag gcc act tca ggt gtc ctt gtt gtg ctg gat gta gtc aac     1092
 Leu Gly Lys Ala Thr Ser Gly Val Leu Val Val Leu Asp Val Val Asn
     290                 295                 300

 ctt gtg caa gac tca ctg gac ttg cac aag ggg gca aaa tcc gag tct     1140
 Leu Val Gln Asp Ser Leu Asp Leu His Lys Gly Ala Lys Ser Glu Ser
 305                 310                 315                 320

 gct gag tcg ctg agg cag tgg gct cag gag ctg gag gag aat ctc aat     1188
 Ala Glu Ser Leu Arg Gln Trp Ala Gln Glu Leu Glu Glu Asn Leu Asn
                 325                 330                 335

 gag ctc acc cat atc cat cag agt cta aaa gca ggc tag gcccaattgt      1237
 Glu Leu Thr His Ile His Gln Ser Leu Lys Ala Gly 
             340                 345

 tgcgggaagt cagggacccc aaacggaggg actggctgaa gccatggcag aagaacgtgg   1297

 attgtgaaga tttcatggac atttattagt tccccaaatt aatactttta taatttccta   1357

 tgcctgtctt taccgcaatc tctaaacaca aattgtgaag atttcatgga cacttatcac   1417

 ttccccaatc aatacccttg tgatttctta tgcctgtctt tactttaatc tcctaatcct   1477

 gtcagctgag gaggatgtat gtcacctcag gaccatgtga taattgcgtt aactgcacaa   1537

 attgtagagc atgtgtgttt gaacaatatg aaatctgggc accttgaaaa aagaacagga   1597

 taacagcaat tgttcaggga ataagagaga taaccttaaa ctctgaccaa cagtgagccg   1657

 ggtggaacag agtcatattt ctcttctttc aaaagcaaat gggagaaata tcgctgaatt   1717

 ctttttctca gcaaggaaca tccctgagaa agagaatgca cccctgaggg tgggtctata   1777

 aatggcctcc ttgggtgtgg ccatcttcta tggtcgagac tgtagggatg aaataaaccc   1837

 cagtctccca tagtgctccc aggcttatta ggaagaggaa attcccgcct aataaatttt   1897

 ggtcagaccg gttgctctca aaaccctgtc tcctgataag atgttatcaa tgacaatggt   1957

 gcctgaaacc tcattagcaa ttntaatttc tccccggtcc tgtggtcctg tgatctcacc   2017

 ctgcctccac ttgccttgtg atattctatt accttgngaa gaggtgatct ttgtgaccac   2077

 accctatcat acactccctt ccttttga                                      2105




      <210> 160
      <211> 1699
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (171)..(1547)

      <400> 160
 tcttcgtcgc cgctctctct ctcacctctc agggaaaggg ggggacatag gggcgtcgcg     60

 gggccccggc gaatgcgccc cccgccgcct ctcgggctgc gccgcctcac tatagggctc    120

 gagcggccgc cgccggcagg tctcgcgggg atgaagcacc ggccgtgaag   atg gag     176
                                                          Met Glu
                                                            1

 gtg acc tgc ctt cta ctt ctg gcg ctg atc ccc ttc cac tgc cgg gga      224
 Val Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys Arg Gly
           5                  10                  15

 caa gga gtc tac gct cca gcc cag gcg cag atc gtg cat gcg ggc cag      272
 Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala Gly Gln
      20                  25                  30

 gca tgt gtg gtg aaa gag gac aat atc agc gag cgt gtc tac acc atc      320
 Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr Thr Ile
  35                  40                  45                  50

 cgg gag ggg gac acc ctc atg ctg cag tgc ctt gta aca ggg cac cct      368
 Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly His Pro
                  55                  60                  65

 cga ccc cag gta cgg tgg acc aag acg gca ggt agc gcc tcg gac aag      416
 Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser Asp Lys
              70                  75                  80

 ttc cag gag aca tcg gtg ttc aac gag acg ctg cgc atc gag cgt att      464
 Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu Arg Ile
          85                  90                  95

 gca cgc acg cag ggc ggc cgc tac tac tgc aag gct gag aac ggc gtg      512
 Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn Gly Val
     100                 105                 110

 ggg gtg ccg gcc atc aag tcc atc cgc gtg gac gtg cag tac ctg gat      560
 Gly Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr Leu Asp
 115                 120                 125                 130

 gag cca atg ctg acg gtg cac cag acg gtg agc gat gtg cga ggc aac      608
 Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg Gly Asn
                 135                 140                 145

 ttc tac cag gag aag acg gtg ttc ctg cgc tgt act gtc aac tcc aac      656
 Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn Ser Asn
             150                 155                 160

 cca cct gcc cgc ttc atc tgg aag cgg ggt tcc gat acc cta tcc cac      704
 Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu Ser His
         165                 170                 175

 agc cag gac aat ggg gtt gac atc tat gag ccc ctc tac act cag ggg      752
 Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr Gln Gly
     180                 185                 190

 gag acc aag gtc ctg aag ctg aag aac ctg cgg ccc cag gac tat gcc      800
 Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp Tyr Ala
 195                 200                 205                 210

 agc tac acc tgc cag gtg tct gtg cgt aac gtg tgc ggc atc cca gac      848
 Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile Pro Asp
                 215                 220                 225

 aag gcc atc acc ttc cgg ctc acc aac acc acg gca cca cca gcc ctg      896
 Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro Ala Leu
             230                 235                 240

 aag ctg tct gtg aac gaa act ctg gtg gtg aac cct ggg gag aat gtg      944
 Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu Asn Val
         245                 250                 255

 acg gtg cag tgt ctg ctg aca ggc ggt gat ccc ctc ccc cag ctg cag      992
 Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln Leu Gln
     260                 265                 270

 tgg tcc cat ggg cct ggc cca ctg ccc ctg ggt gct ctg gcc cag ggt     1040
 Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala Gln Gly
 275                 280                 285                 290

 ggc acc ctc agc atc cct tca gtg cag gcc cgg gac tct ggc tac tac     1088
 Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly Tyr Tyr
                 295                 300                 305

 aac tgc aca gcc acc aac aat gtg ggc aac cct gcc aag aag act gtc     1136
 Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys Thr Val
             310                 315                 320

 aac ctg ctg gtg cga tcc atg aag aac gct aca ttc cag atc act cct     1184
 Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile Thr Pro
         325                 330                 335

 gac gtg atc aaa gag agt gag aac atc cag ctg ggc cag gac ctg aag     1232
 Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp Leu Lys
     340                 345                 350

 cta tcg tgc cac gtg gat gca gtg ccc cag gag aag gtg acc tac cag     1280
 Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr Tyr Gln
 355                 360                 365                 370

 tgg ttc aag aat ggc aag ccg gca cgc atg tcc aag cgg ctg ctg gtg     1328
 Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu Leu Val
                 375                 380                 385

 acc cgc aat gat cct gag ctg ccc gca gtc acc agc agc cta gag ctc     1376
 Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu Glu Leu
             390                 395                 400

 att gac ctg cac ttc agt gac tat ggc acc tac ctg tgc atg gct tct     1424
 Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met Ala Ser
         405                 410                 415

 ttc cca ggg gca ccc gtg ccc gac ctc agc gtc gag gtc aac atc tcc     1472
 Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn Ile Ser
     420                 425                 430

 tct gag aca ggt ggg cag ctg gag ggg cac tgc gga aat gtg agg ggg     1520
 Ser Glu Thr Gly Gly Gln Leu Glu Gly His Cys Gly Asn Val Arg Gly
 435                 440                 445                 450

 gtg gag agg ccc aca gac agg agg tag tgggg aggcaacggc ttgggaaagg     1572
 Val Glu Arg Pro Thr Asp Arg Arg 
                 455

 gaagccagag tgaggaggcc accacttgtt catgccacgt gcttttattg agtccctgtt   1632

 aatatgccag gcactgtgct aggtcctggg gtagagtggt gggcaaaaca ggctcagaac   1692

 aacgaca                                                             1699




      <210> 161
      <211> 3312
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (169)..(3036)

      <400> 161
 ggtcgccgcc acctccgcct cttcagtctc ctggtcttcg tcgccgctct ctctctcacc     60

 tctcagggaa agggggggac ataggggcgt cgcggggccc cggcgaatgc gccccccgcc    120

 gcctctcggg ctgcgccgcc tcgcggggat gaagcaccgg ccgtgaag atg gag gtg     177
                                                      Met Glu Val
                                                        1

 acc tgc ctt cta ctt ctg gcg ctg atc ccc ttc cac tgc cgg gga caa      225
 Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys Arg Gly Gln
       5                  10                  15

 gga gtc tac gct cca gcc cag gcg cag atc gtg cat gcg ggc cag gca      273
 Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala Gly Gln Ala
  20                  25                  30                  35

 tgt gtg gtg aaa gag gac aat atc agc gag cgt gtc tac acc atc cgg      321
 Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr Thr Ile Arg
                  40                  45                  50

 gag ggg gac acc ctc atg ctg cag tgc ctt gta aca ggg cac cct cga      369
 Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly His Pro Arg
              55                  60                  65

 ccc cag gta cgg tgg acc aag acg gca ggt agc gcc tcg gac aag ttc      417
 Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser Asp Lys Phe
          70                  75                  80

 cag gag aca tcg gtg ttc aac gag acg ctg cgc atc gag cgt att gca      465
 Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu Arg Ile Ala
      85                  90                  95

 cgc acg cag ggc ggc cgc tac tac tgc aag gct gag aac ggc gtg ggg      513
 Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn Gly Val Gly
 100                 105                 110                 115

 gtg ccg gcc atc aag tcc atc cgc gtg gac gtg cag tac ctg gat gag      561
 Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr Leu Asp Glu
                 120                 125                 130

 cca atg ctg acg gtg cac cag acg gtg agc gat gtg cga ggc aac ttc      609
 Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg Gly Asn Phe
             135                 140                 145

 tac cag gag aag acg gtg ttc ctg cgc tgt act gtc aac tcc aac cca      657
 Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn Ser Asn Pro
         150                 155                 160

 cct gcc cgc ttc atc tgg aag cgg ggt tcc gat acc cta tcc cac agc      705
 Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu Ser His Ser
     165                 170                 175

 cag gac aat ggg gtt gac atc tat gag ccc ctc tac act cag ggg gag      753
 Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr Gln Gly Glu
 180                 185                 190                 195

 acc aag gtc ctg aag ctg aag aac ctg cgg ccc cag gac tat gcc agc      801
 Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp Tyr Ala Ser
                 200                 205                 210

 tac acc tgc cag gtg tct gtg cgt aac gtg tgc ggc atc cca gac aag      849
 Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile Pro Asp Lys
             215                 220                 225

 gcc atc acc ttc cgg ctc acc aac acc acg gca cca cca gcc ctg aag      897
 Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro Ala Leu Lys
         230                 235                 240

 ctg tct gtg aac gaa act ctg gtg gtg aac cct ggg gag aat gtg acg      945
 Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu Asn Val Thr
     245                 250                 255

 gtg cag tgt ctg ctg aca ggc ggt gat ccc ctc ccc cag ctg cag tgg      993
 Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln Leu Gln Trp
 260                 265                 270                 275

 tcc cat ggg cct ggc cca ctg ccc ctg ggt gct ctg gcc cag ggt ggc     1041
 Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala Gln Gly Gly
                 280                 285                 290

 acc ctc agc atc cct tca gtg cag gcc cgg gac tct ggc tac tac aac     1089
 Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly Tyr Tyr Asn
             295                 300                 305

 tgc aca gcc acc aac aat gtg ggc aac cct gcc aag aag act gtc aac     1137
 Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys Thr Val Asn
         310                 315                 320

 ctg ctg gtg cga tcc atg aag aac gct aca ttc cag atc act cct gac     1185
 Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile Thr Pro Asp
     325                 330                 335

 gtg atc aaa gag agt gag aac atc cag ctg ggc cag gac ctg aag cta     1233
 Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp Leu Lys Leu
 340                 345                 350                 355

 tcg tgc cac gtg gat gca gtg ccc cag gag aag gtg acc tac cag tgg     1281
 Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr Tyr Gln Trp
                 360                 365                 370

 ttc aag aat ggc aag ccg gca cgc atg tcc aag cgg ctg ctg gtg acc     1329
 Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu Leu Val Thr
             375                 380                 385

 cgc aat gat cct gag ctg ccc gca gtc acc agc agc cta gag ctc att     1377
 Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu Glu Leu Ile
         390                 395                 400

 gac ctg cac ttc agt gac tat ggc acc tac ctg tgc atg gct tct ttc     1425
 Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met Ala Ser Phe
     405                 410                 415

 cca ggg gca ccc gtg ccc gac ctc agc gtc gag gtc aac atc tcc tct     1473
 Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn Ile Ser Ser
 420                 425                 430                 435

 gag aca gtg ccg ccc acc atc agt gtg ccc aag ggt agg gcc gtg gtg     1521
 Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg Ala Val Val
                 440                 445                 450

 acc gtg cgc gag gga tcg cct gcc gag ctg caa tgc gag gtg cgg ggc     1569
 Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu Val Arg Gly
             455                 460                 465

 aag ccg cgg ccg cca gtg ctc tgg tcc cgc gtg gac aag gag gct gca     1617
 Lys Pro Arg Pro Pro Val Leu Trp Ser Arg Val Asp Lys Glu Ala Ala
         470                 475                 480

 ctg ctg ccc tcg ggg ctg ccc ctg gag gag act ccg gac ggg aag ctg     1665
 Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu Thr Pro Asp Gly Lys Leu
     485                 490                 495

 cgg ctg gag cga gtg agc cga gac atg agc ggg acc tac cgc tgc cag     1713
 Arg Leu Glu Arg Val Ser Arg Asp Met Ser Gly Thr Tyr Arg Cys Gln
 500                 505                 510                 515

 acg gcc cgc tat aat ggc ttc aac gtg cgc ccc cgt gag gcc cag gtg     1761
 Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg Pro Arg Glu Ala Gln Val
                 520                 525                 530

 cag ctg aac gtg cag ttc ccg ccg gag gtg gag ccc agt tcc cag gac     1809
 Gln Leu Asn Val Gln Phe Pro Pro Glu Val Glu Pro Ser Ser Gln Asp
             535                 540                 545

 gtg cgc cag gcg ctg ggc cgg ccc gtg ctc ctg cgc tgc tcg ctg ctg     1857
 Val Arg Gln Ala Leu Gly Arg Pro Val Leu Leu Arg Cys Ser Leu Leu
         550                 555                 560

 cga ggc agc ccc cag cgc atc gcc tcg gct gtg tgg cgt ttc aaa ggg     1905
 Arg Gly Ser Pro Gln Arg Ile Ala Ser Ala Val Trp Arg Phe Lys Gly
     565                 570                 575

 cag ctg ctg ccg ccg ccg cct gtt gtt ccc gcc gcc gcc gag gcg ccg     1953
 Gln Leu Leu Pro Pro Pro Pro Val Val Pro Ala Ala Ala Glu Ala Pro
 580                 585                 590                 595

 gat cac gcg gag ctg cgc ctc gac gcc gta act cgc gac agc agc ggc     2001
 Asp His Ala Glu Leu Arg Leu Asp Ala Val Thr Arg Asp Ser Ser Gly
                 600                 605                 610

 agc tac gag tgc agc gtc tcc aac gat gtg ggc tcg gct gcc tgc ctc     2049
 Ser Tyr Glu Cys Ser Val Ser Asn Asp Val Gly Ser Ala Ala Cys Leu
             615                 620                 625

 ttc cag gtc tcc gcc aaa gcc tac agc ccg gag ttt tac ttc gac acc     2097
 Phe Gln Val Ser Ala Lys Ala Tyr Ser Pro Glu Phe Tyr Phe Asp Thr
         630                 635                 640

 ccc aac ccc acc cgc agc cac aag ctg tcc aag aac tac tcc tac gtg     2145
 Pro Asn Pro Thr Arg Ser His Lys Leu Ser Lys Asn Tyr Ser Tyr Val
     645                 650                 655

 ctg cag tgg act cag agg gag ccc gac gct gtc gac cct gtg ctc aac     2193
 Leu Gln Trp Thr Gln Arg Glu Pro Asp Ala Val Asp Pro Val Leu Asn
 660                 665                 670                 675

 tac aga ctc agc atc cgc cag ttg aac cag cac aat gcg gtg gtc aag     2241
 Tyr Arg Leu Ser Ile Arg Gln Leu Asn Gln His Asn Ala Val Val Lys
                 680                 685                 690

 gcc atc ccg gtc cgg cgt gtg gag aag ggg cag ctg ctg gag tac atc     2289
 Ala Ile Pro Val Arg Arg Val Glu Lys Gly Gln Leu Leu Glu Tyr Ile
             695                 700                 705

 ctg acc gat ctc cgt gtg ccc cac agc tat gag gtc cgc ctc aca ccc     2337
 Leu Thr Asp Leu Arg Val Pro His Ser Tyr Glu Val Arg Leu Thr Pro
         710                 715                 720

 tat acc acc ttc ggg gct ggt gac atg gcc tcc cgc atc atc cac tac     2385
 Tyr Thr Thr Phe Gly Ala Gly Asp Met Ala Ser Arg Ile Ile His Tyr
     725                 730                 735

 aca gag ccc atc aac tct ccg aac ctt tca gac aac acc tgc cac ttt     2433
 Thr Glu Pro Ile Asn Ser Pro Asn Leu Ser Asp Asn Thr Cys His Phe
 740                 745                 750                 755

 gag gat gag aag atc tgt ggc tat acc cag gac ctg aca gac aac ttt     2481
 Glu Asp Glu Lys Ile Cys Gly Tyr Thr Gln Asp Leu Thr Asp Asn Phe
                 760                 765                 770

 gac tgg acg cgg cag aat gcc ctc acc cag aac ccc aaa cgc tcc ccc     2529
 Asp Trp Thr Arg Gln Asn Ala Leu Thr Gln Asn Pro Lys Arg Ser Pro
             775                 780                 785

 aac act ggt ccc ccc acc gac ata agt ggc acc cct gag ggc tac tac     2577
 Asn Thr Gly Pro Pro Thr Asp Ile Ser Gly Thr Pro Glu Gly Tyr Tyr
         790                 795                 800

 atg ttc atc gag aca tcg agg cct cgg gag ctg ggg gac cgt gca agg     2625
 Met Phe Ile Glu Thr Ser Arg Pro Arg Glu Leu Gly Asp Arg Ala Arg
     805                 810                 815

 tta gtg agt ccc ctc tac aat gcc agc gcc aag ttc tac tgt gtc tcc     2673
 Leu Val Ser Pro Leu Tyr Asn Ala Ser Ala Lys Phe Tyr Cys Val Ser
 820                 825                 830                 835

 ttc ttc tac cac atg tac ggg aaa cac atc ggc tcc ctc aac ctc ctg     2721
 Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu Asn Leu Leu
                 840                 845                 850

 gtg cgg tcc cgg aac aaa ggg gct ctg gac acg cac gcc tgg tct ctc     2769
 Val Arg Ser Arg Asn Lys Gly Ala Leu Asp Thr His Ala Trp Ser Leu
             855                 860                 865

 agt ggc aat aag ggc aat gtg tgg cag cag gcc cat gtg ccc atc agc     2817
 Ser Gly Asn Lys Gly Asn Val Trp Gln Gln Ala His Val Pro Ile Ser
         870                 875                 880

 ccc agt ggg ccc ttc cag att att ttt gag ggg gtt cga ggc ccg ggc     2865
 Pro Ser Gly Pro Phe Gln Ile Ile Phe Glu Gly Val Arg Gly Pro Gly
     885                 890                 895

 tac ctg ggg gat att gcc ata gat gac gtc aca ctg aag aag ggg gag     2913
 Tyr Leu Gly Asp Ile Ala Ile Asp Asp Val Thr Leu Lys Lys Gly Glu
 900                 905                 910                 915

 tgt ccc cgg aag cag acg gat ccc aat aaa gtg gtg gtg atg ccg ggc     2961
 Cys Pro Arg Lys Gln Thr Asp Pro Asn Lys Val Val Val Met Pro Gly
                 920                 925                 930

 agt gga gcc ccc tgc cag tcc agc cca cag ctg tgg ggg ccc atg gcc     3009
 Ser Gly Ala Pro Cys Gln Ser Ser Pro Gln Leu Trp Gly Pro Met Ala
             935                 940                 945

 atc ttc ctc ttg gcg ttg cag aga tga tgaga gctgtgtggc caccccccca     3061
 Ile Phe Leu Leu Ala Leu Gln Arg 
         950                 955

 accttgcccc cggcacacca aagtgtccac attgtaccaa agactgaccc ccgccagctg   3121

 gggtgcccag gggcagggcc ggcccgccag ggagggggcc tgcattggct gcaaggatga   3181

 gcagagaaca aggacagagg ccaggcactg aggccctgga gacagctgtt ccacttgcac   3241

 acacgcacac actcatgctc acacacacag agatatatta aagcacaagt ttctatctga   3301

 aaaaaaaaaa a                                                        3312




      <210> 162
      <211> 1638
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(1590)

      <400> 162
 tttggcacga ggccgcgttg ttcctgtgtt gggggcggc   atg gag cgg gag ccg      54
                                              Met Glu Arg Glu Pro
                                                1               5

 ggc gcc gcg gga gtt cgc cgg gct ctg ggc cgc cgg ctg gag gcg gtg      102
 Gly Ala Ala Gly Val Arg Arg Ala Leu Gly Arg Arg Leu Glu Ala Val
                  10                  15                  20

 ctg gcg agc cgc agt gag gcc aac gcc gtg ttc gac atc ctg gcc gtg      150
 Leu Ala Ser Arg Ser Glu Ala Asn Ala Val Phe Asp Ile Leu Ala Val
              25                  30                  35

 ctg cag tct gag gac cag gag gag atc cag gaa gca gtc cgc acg tgc      198
 Leu Gln Ser Glu Asp Gln Glu Glu Ile Gln Glu Ala Val Arg Thr Cys
          40                  45                  50

 agc cgt ctt ttc ggg gcc ttg ctg gag cgg gga gag ctg ttt gtg ggc      246
 Ser Arg Leu Phe Gly Ala Leu Leu Glu Arg Gly Glu Leu Phe Val Gly
      55                  60                  65

 cag ctg ccc tct gag gag atg gtc atg aca ggg tcc cag gga gcc aca      294
 Gln Leu Pro Ser Glu Glu Met Val Met Thr Gly Ser Gln Gly Ala Thr
  70                  75                  80                  85

 cgg aag tac aag gtg tgg atg aga cac cgc tat cac agc tgc tgc aat      342
 Arg Lys Tyr Lys Val Trp Met Arg His Arg Tyr His Ser Cys Cys Asn
                  90                  95                 100

 cgc ttg gga gag ctc ctg ggc cac ccc tcc ttt cag gtc aag gag ctg      390
 Arg Leu Gly Glu Leu Leu Gly His Pro Ser Phe Gln Val Lys Glu Leu
             105                 110                 115

 gcc ctc agc gca ctc ctg aag ttc gtg cag ctg gaa gga gcg cac ccc      438
 Ala Leu Ser Ala Leu Leu Lys Phe Val Gln Leu Glu Gly Ala His Pro
         120                 125                 130

 ctg gag aag tcc aag tgg gaa ggc aac tac ctg ttc ccc cga gag ctc      486
 Leu Glu Lys Ser Lys Trp Glu Gly Asn Tyr Leu Phe Pro Arg Glu Leu
     135                 140                 145

 ttc aag ttg gtg gtg gga ggc ctg ctg tct cct gag gag gac cag agc      534
 Phe Lys Leu Val Val Gly Gly Leu Leu Ser Pro Glu Glu Asp Gln Ser
 150                 155                 160                 165

 ctg ctc ctg tcc cag ttc cgg gag tac ctg gac tac gac gac acc cgc      582
 Leu Leu Leu Ser Gln Phe Arg Glu Tyr Leu Asp Tyr Asp Asp Thr Arg
                 170                 175                 180

 tac cac acc atg cag gca gcc gtg gat gcc gtg gcc cgg gtc act ggc      630
 Tyr His Thr Met Gln Ala Ala Val Asp Ala Val Ala Arg Val Thr Gly
             185                 190                 195

 cag cac ccc gag gtg ccc ccc gcc ttt tgg aac aat gcc ttc acg ctg      678
 Gln His Pro Glu Val Pro Pro Ala Phe Trp Asn Asn Ala Phe Thr Leu
         200                 205                 210

 ctg tct gcc gtg agc ctg ccc cgc cgg gag ccc acc gtc tcc agc ttc      726
 Leu Ser Ala Val Ser Leu Pro Arg Arg Glu Pro Thr Val Ser Ser Phe
     215                 220                 225

 tat gtg aag cgg gcg gag ctg tgg gac acc tgg aag gtt gct cac ctg      774
 Tyr Val Lys Arg Ala Glu Leu Trp Asp Thr Trp Lys Val Ala His Leu
 230                 235                 240                 245

 aag gag cac agg agg gtt ttc cag gcc atg tgg ctc agc ttc ctc aag      822
 Lys Glu His Arg Arg Val Phe Gln Ala Met Trp Leu Ser Phe Leu Lys
                 250                 255                 260

 cac aag ctg ccc ctc agc ctc tac aag aag gtg ctg ctg att gtg cat      870
 His Lys Leu Pro Leu Ser Leu Tyr Lys Lys Val Leu Leu Ile Val His
             265                 270                 275

 gac gcc atc ctg ccg cag ctg gcg cag ccc acg ctc atg atc gac ttc      918
 Asp Ala Ile Leu Pro Gln Leu Ala Gln Pro Thr Leu Met Ile Asp Phe
         280                 285                 290

 ctc acc cgc gcc tgc gac ctc ggg ggg gcc ctc agc ctc ttg gcc ttg      966
 Leu Thr Arg Ala Cys Asp Leu Gly Gly Ala Leu Ser Leu Leu Ala Leu
     295                 300                 305

 aac ggg ctg ttc atc ttg att cac aaa cac aac ctg gag tac cct gac     1014
 Asn Gly Leu Phe Ile Leu Ile His Lys His Asn Leu Glu Tyr Pro Asp
 310                 315                 320                 325

 ttc tac cgg aag ctc tac ggc ctc ttg gac ccc tct gtc ttt cac gtc     1062
 Phe Tyr Arg Lys Leu Tyr Gly Leu Leu Asp Pro Ser Val Phe His Val
                 330                 335                 340

 aag tac cgc gcc cgc ttc ttc cac ctg gct gac ctc ttc ctg tcc tcc     1110
 Lys Tyr Arg Ala Arg Phe Phe His Leu Ala Asp Leu Phe Leu Ser Ser
             345                 350                 355

 tcc cac ctc ccc gcc tac ctg gtg gcc gcc ttc gcc aag cgg ctg gcc     1158
 Ser His Leu Pro Ala Tyr Leu Val Ala Ala Phe Ala Lys Arg Leu Ala
         360                 365                 370

 cgc ctg gcc ctg acg gct ccc cct gag gcc ctg ctc atg gtc ctg cct     1206
 Arg Leu Ala Leu Thr Ala Pro Pro Glu Ala Leu Leu Met Val Leu Pro
     375                 380                 385

 ttc atc tgt aac ctg ctg cgc cgg cac cct gcc tgc cgg gtc ctc gtg     1254
 Phe Ile Cys Asn Leu Leu Arg Arg His Pro Ala Cys Arg Val Leu Val
 390                 395                 400                 405

 cac cgt cca cac ggc cct gag ttg gac gcc gac ccc tac gac cct gga     1302
 His Arg Pro His Gly Pro Glu Leu Asp Ala Asp Pro Tyr Asp Pro Gly
                 410                 415                 420

 gag gag gac cca gcc cag agc cgg gcc ttg gag agc tcc ctg tgg gag     1350
 Glu Glu Asp Pro Ala Gln Ser Arg Ala Leu Glu Ser Ser Leu Trp Glu
             425                 430                 435

 ctt cag gcc ctc cag cgc cac tac cac cct gag gtg tcc aaa gcc gcc     1398
 Leu Gln Ala Leu Gln Arg His Tyr His Pro Glu Val Ser Lys Ala Ala
         440                 445                 450

 agc gtc atc aac cag gcc ctg tcc atg cct gag gtc agc atc gcg cca     1446
 Ser Val Ile Asn Gln Ala Leu Ser Met Pro Glu Val Ser Ile Ala Pro
     455                 460                 465

 ctg ctg gag ctc acg gcc tac gag atc ttt gag cgg gac ctg aag aag     1494
 Leu Leu Glu Leu Thr Ala Tyr Glu Ile Phe Glu Arg Asp Leu Lys Lys
 470                 475                 480                 485

 aag ggg ccc gag ccg gtg cca ctg gag ttt atc cca gcc cag ggc ctg     1542
 Lys Gly Pro Glu Pro Val Pro Leu Glu Phe Ile Pro Ala Gln Gly Leu
                 490                 495                 500

 ctg gga cgg ccg ggt gaa ctc tgt gcc cag cac ttc acg ctc agc tga     1590
 Leu Gly Arg Pro Gly Glu Leu Cys Ala Gln His Phe Thr Leu Ser 
             505                 510                 515

 ccctggccca cctgtgaata aatctcagct gaccccaaaa aaaaaaaa                1638




      <210> 163
      <211> 4820
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4803)

      <400> 163
  atg cac gac gct ttc gag cca gtg ccg atc cta gaa aag ctg cct ctg      48
  Met His Asp Ala Phe Glu Pro Val Pro Ile Leu Glu Lys Leu Pro Leu
    1               5                  10                  15

 caa atc gac tgt ctg gct gcc tgg gag gaa tgg ctt ctt gtg gga acc       96
 Gln Ile Asp Cys Leu Ala Ala Trp Glu Glu Trp Leu Leu Val Gly Thr
              20                  25                  30

 aaa caa gga cat ctt ctt ctc tat agg att cgg aag gac gtt gtg cca      144
 Lys Gln Gly His Leu Leu Leu Tyr Arg Ile Arg Lys Asp Val Val Pro
          35                  40                  45

 gca gat gta gca tca cct gaa agc ggc agt tgc aac aga ttt gaa gtg      192
 Ala Asp Val Ala Ser Pro Glu Ser Gly Ser Cys Asn Arg Phe Glu Val
      50                  55                  60

 aca cta gag aaa tcc aat aag aac ttc tcc aaa aag att cag cag cac      240
 Thr Leu Glu Lys Ser Asn Lys Asn Phe Ser Lys Lys Ile Gln Gln His
  65                  70                  75                  80

 aca gag acc ggt gag gag gtg tta cgg atg tgt gtg gca gta aaa aag      288
 Thr Glu Thr Gly Glu Glu Val Leu Arg Met Cys Val Ala Val Lys Lys
                  85                  90                  95

 aag ctg cag ctc tat ttc tgg aag gac agg gaa ttt cat gaa ttg cag      336
 Lys Leu Gln Leu Tyr Phe Trp Lys Asp Arg Glu Phe His Glu Leu Gln
             100                 105                 110

 gtg gat gga aag ggg tcc atc aaa gag ctc ttt cca aca gga aaa cag      384
 Val Asp Gly Lys Gly Ser Ile Lys Glu Leu Phe Pro Thr Gly Lys Gln
         115                 120                 125

 ctg gag ccc tta gtt gca cct ctg gca gat gga aaa gtg gct gtg ggc      432
 Leu Glu Pro Leu Val Ala Pro Leu Ala Asp Gly Lys Val Ala Val Gly
     130                 135                 140

 cag gat gat ctc acc gtg gta ctc aat gag gaa ggg atc tgc aca cag      480
 Gln Asp Asp Leu Thr Val Val Leu Asn Glu Glu Gly Ile Cys Thr Gln
 145                 150                 155                 160

 aaa tgt gcc ctg aac tgg acg gac ata cca gtg gcc atg gag cac cag      528
 Lys Cys Ala Leu Asn Trp Thr Asp Ile Pro Val Ala Met Glu His Gln
                 165                 170                 175

 cct ccc tac atc att gca gtg ttg cct cga tat gtt gag atc cga aca      576
 Pro Pro Tyr Ile Ile Ala Val Leu Pro Arg Tyr Val Glu Ile Arg Thr
             180                 185                 190

 ttt gaa ccg agg ctt ctg gtc caa agc att gaa ttg caa agg ccc cgt      624
 Phe Glu Pro Arg Leu Leu Val Gln Ser Ile Glu Leu Gln Arg Pro Arg
         195                 200                 205

 ttc att acc tca gga gga tca aac att atc tat gtg gcc agc aat cat      672
 Phe Ile Thr Ser Gly Gly Ser Asn Ile Ile Tyr Val Ala Ser Asn His
     210                 215                 220

 ttt gtt tgg aga ctc atc cct gtc ccc atg gca acc caa atc caa caa      720
 Phe Val Trp Arg Leu Ile Pro Val Pro Met Ala Thr Gln Ile Gln Gln
 225                 230                 235                 240

 ctt ctc cag gac aag cag ttt gaa ttg gct ctg cag ctc gca gaa atg      768
 Leu Leu Gln Asp Lys Gln Phe Glu Leu Ala Leu Gln Leu Ala Glu Met
                 245                 250                 255

 aaa gat gat tct gac agt gaa aag cag caa caa att cat cac atc aag      816
 Lys Asp Asp Ser Asp Ser Glu Lys Gln Gln Gln Ile His His Ile Lys
             260                 265                 270

 aac ttg tat gcc ttc aac ctc ttc tgc cag aag cgt ttt gat gag tcc      864
 Asn Leu Tyr Ala Phe Asn Leu Phe Cys Gln Lys Arg Phe Asp Glu Ser
         275                 280                 285

 atg cag gtc ttt gct aaa ctt ggc aca gac tac aga aag cag ttg cag      912
 Met Gln Val Phe Ala Lys Leu Gly Thr Asp Tyr Arg Lys Gln Leu Gln
     290                 295                 300

 tat ccc aac cca ttg cct gtg ctc tcc ggg gct gaa ttg gag aag gct      960
 Tyr Pro Asn Pro Leu Pro Val Leu Ser Gly Ala Glu Leu Glu Lys Ala
 305                 310                 315                 320

 cac tta gct ctg att gac tac ctg aca cag aaa cga agt caa ttg gta     1008
 His Leu Ala Leu Ile Asp Tyr Leu Thr Gln Lys Arg Ser Gln Leu Val
                 325                 330                 335

 aag aag ctg aat gac tct gat cac cag tca agc acc tca ccg ctc atg     1056
 Lys Lys Leu Asn Asp Ser Asp His Gln Ser Ser Thr Ser Pro Leu Met
             340                 345                 350

 gaa ggc act ccc acc atc aaa tcc aag aag aag ctg cta caa atc atc     1104
 Glu Gly Thr Pro Thr Ile Lys Ser Lys Lys Lys Leu Leu Gln Ile Ile
         355                 360                 365

 gac acc acc ctg ctc aag tgc tat ctc cat aca aat gtg gcc ctg gtg     1152
 Asp Thr Thr Leu Leu Lys Cys Tyr Leu His Thr Asn Val Ala Leu Val
     370                 375                 380

 gcc ccc ttg cta cgc ctg gag aac aat cac tgc cac atc gag gag agc     1200
 Ala Pro Leu Leu Arg Leu Glu Asn Asn His Cys His Ile Glu Glu Ser
 385                 390                 395                 400

 gag cac gtg cta aag aag gct cac aag tac agt gag ctt atc atc ctg     1248
 Glu His Val Leu Lys Lys Ala His Lys Tyr Ser Glu Leu Ile Ile Leu
                 405                 410                 415

 tat gag aag aag ggg ctc cac gag aaa gct ctg cag gtg ctc gtg gac     1296
 Tyr Glu Lys Lys Gly Leu His Glu Lys Ala Leu Gln Val Leu Val Asp
             420                 425                 430

 cag tcc aag aaa gcc aac tcc cct ctg aaa ggc cac gag agg aca gtg     1344
 Gln Ser Lys Lys Ala Asn Ser Pro Leu Lys Gly His Glu Arg Thr Val
         435                 440                 445

 cag tat ctg cag cat ctg ggc aca gaa aac ctg cat ttg att ttc tcc     1392
 Gln Tyr Leu Gln His Leu Gly Thr Glu Asn Leu His Leu Ile Phe Ser
     450                 455                 460

 tac tca gtg tgg gtg ctg aga gac ttc cca gaa gat ggc ctg aag ata     1440
 Tyr Ser Val Trp Val Leu Arg Asp Phe Pro Glu Asp Gly Leu Lys Ile
 465                 470                 475                 480

 ttt act gaa gat ctc ccg gaa gtg gag tct ctg cca cgt gat cga gtc     1488
 Phe Thr Glu Asp Leu Pro Glu Val Glu Ser Leu Pro Arg Asp Arg Val
                 485                 490                 495

 ctc ggc ttc tta ata gag aat ttt aag ggt ctg gct att cct tat ctg     1536
 Leu Gly Phe Leu Ile Glu Asn Phe Lys Gly Leu Ala Ile Pro Tyr Leu
             500                 505                 510

 gaa cac atc atc cat gtt tgg gag gag aca ggc tct cgg ttc cac aac     1584
 Glu His Ile Ile His Val Trp Glu Glu Thr Gly Ser Arg Phe His Asn
         515                 520                 525

 tgc ctg atc cag cta tac tgt gag aag gtg caa ggt ctg atg aag gag     1632
 Cys Leu Ile Gln Leu Tyr Cys Glu Lys Val Gln Gly Leu Met Lys Glu
     530                 535                 540

 tat ctc ctg tcc ttc cct gca ggc aaa acc cca gtc cca gct gga gag     1680
 Tyr Leu Leu Ser Phe Pro Ala Gly Lys Thr Pro Val Pro Ala Gly Glu
 545                 550                 555                 560

 gaa gag ggt gag ctg gga gaa tac cgg caa aag ctc ctc atg ttc ttg     1728
 Glu Glu Gly Glu Leu Gly Glu Tyr Arg Gln Lys Leu Leu Met Phe Leu
                 565                 570                 575

 gag att tcc agc tac tat gat cca ggc cgg ctc atc tgt gat ttt ccc     1776
 Glu Ile Ser Ser Tyr Tyr Asp Pro Gly Arg Leu Ile Cys Asp Phe Pro
             580                 585                 590

 ttt gat ggc ctc tta gaa gaa cga gct ctc ctg ttg ggg cgc atg ggg     1824
 Phe Asp Gly Leu Leu Glu Glu Arg Ala Leu Leu Leu Gly Arg Met Gly
         595                 600                 605

 aaa cat gaa caa gct ctt ttc att tat gtc cac atc ttg aag gat aca     1872
 Lys His Glu Gln Ala Leu Phe Ile Tyr Val His Ile Leu Lys Asp Thr
     610                 615                 620

 agg atg gct gag gag tac tgc cac aaa cac tat gac cga aac aaa gat     1920
 Arg Met Ala Glu Glu Tyr Cys His Lys His Tyr Asp Arg Asn Lys Asp
 625                 630                 635                 640

 ggc aac aaa gat gtg tat ctg tcc ctg ctt cgg atg tac ctg tcg ccc     1968
 Gly Asn Lys Asp Val Tyr Leu Ser Leu Leu Arg Met Tyr Leu Ser Pro
                 645                 650                 655

 ccc agc att cac tgc ctg ggg cca atc aag ctg gaa cta ctg gag cca     2016
 Pro Ser Ile His Cys Leu Gly Pro Ile Lys Leu Glu Leu Leu Glu Pro
             660                 665                 670

 aaa gcc aac ctc cag gcc gct ctg cag gtc ctc gag cta cac cac agc     2064
 Lys Ala Asn Leu Gln Ala Ala Leu Gln Val Leu Glu Leu His His Ser
         675                 680                 685

 aaa ctg gac acc acc aag gcc ctc aac ctt ctg cca gca aac act cag     2112
 Lys Leu Asp Thr Thr Lys Ala Leu Asn Leu Leu Pro Ala Asn Thr Gln
     690                 695                 700

 atc aat gac ata cgc atc ttc ctg gaa aag gtc ttg gaa gaa aat gca     2160
 Ile Asn Asp Ile Arg Ile Phe Leu Glu Lys Val Leu Glu Glu Asn Ala
 705                 710                 715                 720

 caa aag aaa cgg ttc aat caa gtg ctc aag aac ctt ctc cat gca gaa     2208
 Gln Lys Lys Arg Phe Asn Gln Val Leu Lys Asn Leu Leu His Ala Glu
                 725                 730                 735

 ttc ctg agg gtc cag gaa gag cgg att tta cac cag cag gtg aag tgc     2256
 Phe Leu Arg Val Gln Glu Glu Arg Ile Leu His Gln Gln Val Lys Cys
             740                 745                 750

 atc atc aca gag gag aag gtg tgc atg gtg tgt aag aag aag att ggg     2304
 Ile Ile Thr Glu Glu Lys Val Cys Met Val Cys Lys Lys Lys Ile Gly
         755                 760                 765

 aac agt gca ttt gca aga tac ccc aat gga gtg gtc gtc cat tac ttc     2352
 Asn Ser Ala Phe Ala Arg Tyr Pro Asn Gly Val Val Val His Tyr Phe
     770                 775                 780

 tgt tcc aaa gag cgg gaa acc tac cca tac tat gac ctc cag gtg aag     2400
 Cys Ser Lys Glu Arg Glu Thr Tyr Pro Tyr Tyr Asp Leu Gln Val Lys
 785                 790                 795                 800

 gtg ctg agg gcc aca aac atc cgg ggc aca gac ctg ctg tcc aaa gcc     2448
 Val Leu Arg Ala Thr Asn Ile Arg Gly Thr Asp Leu Leu Ser Lys Ala
                 805                 810                 815

 gac tgc tat gtg caa ctg tgg ctg ccc acg gcg tcc cca agc cct gcc     2496
 Asp Cys Tyr Val Gln Leu Trp Leu Pro Thr Ala Ser Pro Ser Pro Ala
             820                 825                 830

 cag act agg ata gtg gcc aac tgc agt gac ccc gag tgg aat gag acc     2544
 Gln Thr Arg Ile Val Ala Asn Cys Ser Asp Pro Glu Trp Asn Glu Thr
         835                 840                 845

 ttc cac tac cag atc cat ggt gct gtg aag aac gtc ctg gag ctc acc     2592
 Phe His Tyr Gln Ile His Gly Ala Val Lys Asn Val Leu Glu Leu Thr
     850                 855                 860

 ctt tat gac aag gac atc ctg ggc agc gac cag ctc tcc ctg ctc ctg     2640
 Leu Tyr Asp Lys Asp Ile Leu Gly Ser Asp Gln Leu Ser Leu Leu Leu
 865                 870                 875                 880

 ttt gac ctg aga agc ctc aag tgt ggc caa cct cac aaa cac acc ttc     2688
 Phe Asp Leu Arg Ser Leu Lys Cys Gly Gln Pro His Lys His Thr Phe
                 885                 890                 895

 cca ctc aac cac cag gat tca caa gag ctg cag gtg gaa ttt gtt ctg     2736
 Pro Leu Asn His Gln Asp Ser Gln Glu Leu Gln Val Glu Phe Val Leu
             900                 905                 910

 gag aag agc cag gtg cct gca tct gaa gtc atc acc aac ggg gtt ctg     2784
 Glu Lys Ser Gln Val Pro Ala Ser Glu Val Ile Thr Asn Gly Val Leu
         915                 920                 925

 gtg gct cac ccc tgt ctg aga atc cag ggc acg ctc cgg gga gat ggg     2832
 Val Ala His Pro Cys Leu Arg Ile Gln Gly Thr Leu Arg Gly Asp Gly
     930                 935                 940

 aca gcc cca cgg gaa gag tac ggc tct agg cag ctc cag ctg gca gtg     2880
 Thr Ala Pro Arg Glu Glu Tyr Gly Ser Arg Gln Leu Gln Leu Ala Val
 945                 950                 955                 960

 cct gga gcc tac gag aag cca cag ctc ttg ccc ctg cag cct ccc aca     2928
 Pro Gly Ala Tyr Glu Lys Pro Gln Leu Leu Pro Leu Gln Pro Pro Thr
                 965                 970                 975

 gag cca ggc ctc cca ccc acc ttt acc ttc cac gtg aac cca gtg ctg     2976
 Glu Pro Gly Leu Pro Pro Thr Phe Thr Phe His Val Asn Pro Val Leu
             980                 985                 990

 agc tcc agg cta cac gtg gag ctg atg gag ctg ctg gca gct gtg cag     3024
 Ser Ser Arg Leu His Val Glu Leu Met Glu Leu Leu Ala Ala Val Gln
         995                1000                1005

 agt ggc ccc agc gca gag ttg gag gct cag acc agc aag ctg ggc gag     3072
 Ser Gly Pro Ser Ala Glu Leu Glu Ala Gln Thr Ser Lys Leu Gly Glu
    1010                1015                1020

 ggg ggc atc ctg ctc tcc tct ctg ccc cta ggc cag gag gaa cag tgt     3120
 Gly Gly Ile Leu Leu Ser Ser Leu Pro Leu Gly Gln Glu Glu Gln Cys
1025                1030                1035                1040

 tct gtg gcc ctg ggg gag ggg gag gga gtg gct ctg agc atg acg gtg     3168
 Ser Val Ala Leu Gly Glu Gly Glu Gly Val Ala Leu Ser Met Thr Val
                1045                1050                1055

 gaa atg agc tcc ggg gac cta gac cta cgc ctt ggc ttt gac ctc tct     3216
 Glu Met Ser Ser Gly Asp Leu Asp Leu Arg Leu Gly Phe Asp Leu Ser
            1060                1065                1070

 gac ggg gag cag gag ttt ctg gac agg agg aag cag gtc gtg tcc aag     3264
 Asp Gly Glu Gln Glu Phe Leu Asp Arg Arg Lys Gln Val Val Ser Lys
        1075                1080                1085

 gcc ctg cag caa gtg ctg gga ttg agt gag gct ctg gac agt ggc cag     3312
 Ala Leu Gln Gln Val Leu Gly Leu Ser Glu Ala Leu Asp Ser Gly Gln
    1090                1095                1100

 gtg cct gta gtg gct gtg ttg ggt tcc ggg ggt gga acc cga gcc atg     3360
 Val Pro Val Val Ala Val Leu Gly Ser Gly Gly Gly Thr Arg Ala Met
1105                1110                1115                1120

 tct tct ctg tac ggc agc ctg gca ggg ttg cag gag ctc ggc ctt cta     3408
 Ser Ser Leu Tyr Gly Ser Leu Ala Gly Leu Gln Glu Leu Gly Leu Leu
                1125                1130                1135

 gac act gtg acc tac ctg agt ggg gtc tct ggg tct acc tgg tgc atc     3456
 Asp Thr Val Thr Tyr Leu Ser Gly Val Ser Gly Ser Thr Trp Cys Ile
            1140                1145                1150

 tcc aca ctc tac agg gac cca gcc tgg tcc cag gtg gcc ttg cag ggc     3504
 Ser Thr Leu Tyr Arg Asp Pro Ala Trp Ser Gln Val Ala Leu Gln Gly
        1155                1160                1165

 ccc att gag cgt gcc cag gtt cac gtc tgc agc agt aag atg gga gct     3552
 Pro Ile Glu Arg Ala Gln Val His Val Cys Ser Ser Lys Met Gly Ala
    1170                1175                1180

 ttg tcc acg gag cgg cta cag tac tac act cag gaa ctg ggg gtc cgg     3600
 Leu Ser Thr Glu Arg Leu Gln Tyr Tyr Thr Gln Glu Leu Gly Val Arg
1185                1190                1195                1200

 gag cgc agt ggc cac agc gtg tcc ctc atc gac ctc tgg ggc ctc ctt     3648
 Glu Arg Ser Gly His Ser Val Ser Leu Ile Asp Leu Trp Gly Leu Leu
                1205                1210                1215

 gtt gag tat ctc ctg tac cag gag gag aac cct gcc aag ctg tct gac     3696
 Val Glu Tyr Leu Leu Tyr Gln Glu Glu Asn Pro Ala Lys Leu Ser Asp
            1220                1225                1230

 caa cag aag gcg gtc cgc cag ggt caa aac cct tac ccc att tac acc     3744
 Gln Gln Lys Ala Val Arg Gln Gly Gln Asn Pro Tyr Pro Ile Tyr Thr
        1235                1240                1245

 agt gtc aac gtc cgc acc aac ttg agt ggg gaa gat ttt gca aag tgg     3792
 Ser Val Asn Val Arg Thr Asn Leu Ser Gly Glu Asp Phe Ala Lys Trp
    1250                1255                1260

 tgc gag ttc acg ccc tat aag gtt ggc ttc ccc aag tac ggg gct tat     3840
 Cys Glu Phe Thr Pro Tyr Lys Val Gly Phe Pro Lys Tyr Gly Ala Tyr
1265                1270                1275                1280

 gtt ccc acc gag ctc ttc ggc tca gaa ctc ttc atg gga cga ttg ctg     3888
 Val Pro Thr Glu Leu Phe Gly Ser Glu Leu Phe Met Gly Arg Leu Leu
                1285                1290                1295

 cag ctc cag cct gaa ccc cgg atc tgt tac ctg caa ggt atg tgg ggc     3936
 Gln Leu Gln Pro Glu Pro Arg Ile Cys Tyr Leu Gln Gly Met Trp Gly
            1300                1305                1310

 agc gcc ttt gcc acc agc ctg gat gag atc ttc cta aag acc gcc ggc     3984
 Ser Ala Phe Ala Thr Ser Leu Asp Glu Ile Phe Leu Lys Thr Ala Gly
        1315                1320                1325

 tcg ggc ctc agc ttc ctg gag tgg tac aga ggc agt gtg aat atc aca     4032
 Ser Gly Leu Ser Phe Leu Glu Trp Tyr Arg Gly Ser Val Asn Ile Thr
    1330                1335                1340

 gac gac tgc cag aag cct cag ctg cac aac ccc tcg agg ctg cga acg     4080
 Asp Asp Cys Gln Lys Pro Gln Leu His Asn Pro Ser Arg Leu Arg Thr
1345                1350                1355                1360

 agg ctc ctc acc cca cag ggg ccc ttc tcc cag gct gtg ctg gac ata     4128
 Arg Leu Leu Thr Pro Gln Gly Pro Phe Ser Gln Ala Val Leu Asp Ile
                1365                1370                1375

 ttc acc tcc cgc ttc act tcc gcc cag agc ttt aac ttc acc cgg ggt     4176
 Phe Thr Ser Arg Phe Thr Ser Ala Gln Ser Phe Asn Phe Thr Arg Gly
            1380                1385                1390

 ctc tgc ttg cac aag gac tat gtg gct ggc agg gag ttc gtg gcc tgg     4224
 Leu Cys Leu His Lys Asp Tyr Val Ala Gly Arg Glu Phe Val Ala Trp
        1395                1400                1405

 aaa gac aca cac ccg gac gcc ttc ccc aac cag ctc acc ccc atg cgg     4272
 Lys Asp Thr His Pro Asp Ala Phe Pro Asn Gln Leu Thr Pro Met Arg
    1410                1415                1420

 gac tgc ctg tac ctg gtg gac gga ggc ttt gcc atc aac tct ccg ttc     4320
 Asp Cys Leu Tyr Leu Val Asp Gly Gly Phe Ala Ile Asn Ser Pro Phe
1425                1430                1435                1440

 cca ctg gct ctg ctg cct cag aga gca gtg gac ctc att ctg tcc ttt     4368
 Pro Leu Ala Leu Leu Pro Gln Arg Ala Val Asp Leu Ile Leu Ser Phe
                1445                1450                1455

 gac tat tcc ttg gaa gcc cct ttt gag gtc ttg aag atg aca gag aag     4416
 Asp Tyr Ser Leu Glu Ala Pro Phe Glu Val Leu Lys Met Thr Glu Lys
            1460                1465                1470

 tac tgc ctg gac cga gga atc ccc ttc cct agc atc gag gtg ggc cct     4464
 Tyr Cys Leu Asp Arg Gly Ile Pro Phe Pro Ser Ile Glu Val Gly Pro
        1475                1480                1485

 gag gac gtg gag gag gcc cgt gag tgc tat ctg ttt gcc aag gct gag     4512
 Glu Asp Val Glu Glu Ala Arg Glu Cys Tyr Leu Phe Ala Lys Ala Glu
    1490                1495                1500

 gac ccc cgc tcc ccc att gtg ctg cac ttc ccc ctg gtt aac cgt acc     4560
 Asp Pro Arg Ser Pro Ile Val Leu His Phe Pro Leu Val Asn Arg Thr
1505                1510                1515                1520

 ttc cgc aca cac ctg gcc cca ggt gtg gag cga caa aca gct gag gag     4608
 Phe Arg Thr His Leu Ala Pro Gly Val Glu Arg Gln Thr Ala Glu Glu
                1525                1530                1535

 aag gcc ttt ggg gac ttt gtc atc aac agg cca gac acc ccc tat ggc     4656
 Lys Ala Phe Gly Asp Phe Val Ile Asn Arg Pro Asp Thr Pro Tyr Gly
            1540                1545                1550

 atg atg aac ttc acc tat gag ccc cag gac ttt tat cgg ctg gtg gcc     4704
 Met Met Asn Phe Thr Tyr Glu Pro Gln Asp Phe Tyr Arg Leu Val Ala
        1555                1560                1565

 ctc agt cga tac aac gtc ctg aac aac gtg gag acc ttg aag tgc gcc     4752
 Leu Ser Arg Tyr Asn Val Leu Asn Asn Val Glu Thr Leu Lys Cys Ala
    1570                1575                1580

 ctc cag ctg gct ctg gac cgg cac cag gct cgg gag agg gca ggg gcc     4800
 Leu Gln Leu Ala Leu Asp Arg His Gln Ala Arg Glu Arg Ala Gly Ala
1585                1590                1595                1600

 tga ccctcagaac aacgaca                                              4820
 






      <210> 164
      <211> 2914
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(2627)

      <400> 164
 gtcacacctg agccagcagt ttgtgcaacc agaggagcgc aggcagggtt ccctgctggg     60

 gcccgggctg cccagcc   atg ctt tgg gca ctc tgg cca agg tgg ctg gca     110
                      Met Leu Trp Ala Leu Trp Pro Arg Trp Leu Ala
                        1               5                  10

 gac aag atg ctg ccc ctc ctg ggg gca gtg ctg ctt cag aag aga gag      158
 Asp Lys Met Leu Pro Leu Leu Gly Ala Val Leu Leu Gln Lys Arg Glu
              15                  20                  25

 aag agg ggc cct ctg tgg agg cac tgg cgg cgg gaa acc tac cca tac      206
 Lys Arg Gly Pro Leu Trp Arg His Trp Arg Arg Glu Thr Tyr Pro Tyr
          30                  35                  40

 tat gac ctc cag gtg aag gtg ctg agg gcc aca aac atc cgg ggc aca      254
 Tyr Asp Leu Gln Val Lys Val Leu Arg Ala Thr Asn Ile Arg Gly Thr
      45                  50                  55

 gac ctg ctg tcc aaa gcc gac tgc tat gtg caa ctg tgg ctg ccc acg      302
 Asp Leu Leu Ser Lys Ala Asp Cys Tyr Val Gln Leu Trp Leu Pro Thr
  60                  65                  70                  75

 gcg tcc cca agc cct gcc cag act agg ata gtg gcc aac tgc agt gac      350
 Ala Ser Pro Ser Pro Ala Gln Thr Arg Ile Val Ala Asn Cys Ser Asp
                  80                  85                  90

 ccc gag tgg aat gag acc ttc cac tac cag atc cat ggt gct gtg aag      398
 Pro Glu Trp Asn Glu Thr Phe His Tyr Gln Ile His Gly Ala Val Lys
              95                 100                 105

 aac gtc ctg gag ctc acc ctc tat gac aag gac atc ctg ggc agc gac      446
 Asn Val Leu Glu Leu Thr Leu Tyr Asp Lys Asp Ile Leu Gly Ser Asp
         110                 115                 120

 cag ctc tct ctg ctc ctg ttt gac ctg aga agc ctc aag tgt ggc caa      494
 Gln Leu Ser Leu Leu Leu Phe Asp Leu Arg Ser Leu Lys Cys Gly Gln
     125                 130                 135

 cct cac aaa cac acc ttc cca ctc aac cac cag gat tca caa gag ctg      542
 Pro His Lys His Thr Phe Pro Leu Asn His Gln Asp Ser Gln Glu Leu
 140                 145                 150                 155

 cag gtg gaa ttt gtt ctg gag aag agc cag gtg cct gca tct gaa gtc      590
 Gln Val Glu Phe Val Leu Glu Lys Ser Gln Val Pro Ala Ser Glu Val
                 160                 165                 170

 atc acc aac ggg gtt ctg gtg gct cac ccc tgt ctg aga atc cag ggc      638
 Ile Thr Asn Gly Val Leu Val Ala His Pro Cys Leu Arg Ile Gln Gly
             175                 180                 185

 acg ctc cgg gga gat ggg aca gcc cca cgg gaa gag tac ggc tct agg      686
 Thr Leu Arg Gly Asp Gly Thr Ala Pro Arg Glu Glu Tyr Gly Ser Arg
         190                 195                 200

 cag ctc cag ctg gca gtg cct gga gcc tac gag aag cca cag ctc ttg      734
 Gln Leu Gln Leu Ala Val Pro Gly Ala Tyr Glu Lys Pro Gln Leu Leu
     205                 210                 215

 ccc ctg cag cct ccc aca gag cca ggc ctc cca ccc agc ttt acc ttc      782
 Pro Leu Gln Pro Pro Thr Glu Pro Gly Leu Pro Pro Ser Phe Thr Phe
 220                 225                 230                 235

 cac gtg aac cca gtg ctg agc tcc agg cta cac gtg gag ctg atg gag      830
 His Val Asn Pro Val Leu Ser Ser Arg Leu His Val Glu Leu Met Glu
                 240                 245                 250

 ctg ctg gca gct gtg cag agt ggc ccc agc gca gag ttg gag gct cag      878
 Leu Leu Ala Ala Val Gln Ser Gly Pro Ser Ala Glu Leu Glu Ala Gln
             255                 260                 265

 acc agc aag ctg ggc gag ggg ggc atc ctg ctc tcc tct ctg ccc cta      926
 Thr Ser Lys Leu Gly Glu Gly Gly Ile Leu Leu Ser Ser Leu Pro Leu
         270                 275                 280

 ggc cag gag gaa cag tgt tct gtg gcc ctg ggg gag ggc cag gag gtg      974
 Gly Gln Glu Glu Gln Cys Ser Val Ala Leu Gly Glu Gly Gln Glu Val
     285                 290                 295

 gct ctg agc atg aag gtg gaa atg agc tcc ggg gac cta gac cta cgc     1022
 Ala Leu Ser Met Lys Val Glu Met Ser Ser Gly Asp Leu Asp Leu Arg
 300                 305                 310                 315

 ctt ggc ttt gac ctc tct gac ggg gag cag gag ttt ctg gac agg agg     1070
 Leu Gly Phe Asp Leu Ser Asp Gly Glu Gln Glu Phe Leu Asp Arg Arg
                 320                 325                 330

 aag cag gtc gtg tcc aag gcc ctg cag caa gtg ctg gga ttg agt gag     1118
 Lys Gln Val Val Ser Lys Ala Leu Gln Gln Val Leu Gly Leu Ser Glu
             335                 340                 345

 gct ctg gac agt acc cag gtg cct gta gtg gct gtg ttg ggt tcc ggg     1166
 Ala Leu Asp Ser Thr Gln Val Pro Val Val Ala Val Leu Gly Ser Gly
         350                 355                 360

 ggt gga acc cga gcc atg tct tct ctg tac ggc agc ctg gca ggg ttg     1214
 Gly Gly Thr Arg Ala Met Ser Ser Leu Tyr Gly Ser Leu Ala Gly Leu
     365                 370                 375

 cag gag ctc ggc ctt cta gac act gtg acc tac ctg agt ggg gtc tct     1262
 Gln Glu Leu Gly Leu Leu Asp Thr Val Thr Tyr Leu Ser Gly Val Ser
 380                 385                 390                 395

 ggg tct acc tgg tgc atc tcc aca ctc tac agg gac cca gcc tgg tcc     1310
 Gly Ser Thr Trp Cys Ile Ser Thr Leu Tyr Arg Asp Pro Ala Trp Ser
                 400                 405                 410

 cag gtg gcc ttg cag ggc ccc att gag cgt gcc cag gtt cac gtc tgc     1358
 Gln Val Ala Leu Gln Gly Pro Ile Glu Arg Ala Gln Val His Val Cys
             415                 420                 425

 agc agt aag atg gga gct ttg tcc acg gag cgg cta cag tac tac act     1406
 Ser Ser Lys Met Gly Ala Leu Ser Thr Glu Arg Leu Gln Tyr Tyr Thr
         430                 435                 440

 cag gaa ctg ggg gtc cgg gag cgc agt ggc cac agt gtg tcc ctc atc     1454
 Gln Glu Leu Gly Val Arg Glu Arg Ser Gly His Ser Val Ser Leu Ile
     445                 450                 455

 gac ctc tgg ggc ctc ctt gtt gag tat ctc ctg tac cag gag gag aac     1502
 Asp Leu Trp Gly Leu Leu Val Glu Tyr Leu Leu Tyr Gln Glu Glu Asn
 460                 465                 470                 475

 cct gcc aag ctg tct gac caa cag gag gcg gtc cgc cag ggt cag aac     1550
 Pro Ala Lys Leu Ser Asp Gln Gln Glu Ala Val Arg Gln Gly Gln Asn
                 480                 485                 490

 cct tac ccc att tac acc agt gtc aac gtc cgc acc aac ttg agt ggg     1598
 Pro Tyr Pro Ile Tyr Thr Ser Val Asn Val Arg Thr Asn Leu Ser Gly
             495                 500                 505

 gaa gat ttt gca gag tgg tgc gag ttc acg ccc tat gag gtt ggc ttc     1646
 Glu Asp Phe Ala Glu Trp Cys Glu Phe Thr Pro Tyr Glu Val Gly Phe
         510                 515                 520

 ccc aag tac ggg gct tat gtt ccc acc gag ctc ttc ggc tca gaa ctc     1694
 Pro Lys Tyr Gly Ala Tyr Val Pro Thr Glu Leu Phe Gly Ser Glu Leu
     525                 530                 535

 ttc atg gga cga ttg ctg cag ctc cag cct gaa ccc cgg atc tgt tac     1742
 Phe Met Gly Arg Leu Leu Gln Leu Gln Pro Glu Pro Arg Ile Cys Tyr
 540                 545                 550                 555

 ctg caa ggt atg tgg ggc agc gcc ttt gcc acc agc ctg gat gag atc     1790
 Leu Gln Gly Met Trp Gly Ser Ala Phe Ala Thr Ser Leu Asp Glu Ile
                 560                 565                 570

 ttc cta aag acc gcc ggc tcg ggc ctc agc ttc ctg gag tgg tac aga     1838
 Phe Leu Lys Thr Ala Gly Ser Gly Leu Ser Phe Leu Glu Trp Tyr Arg
             575                 580                 585

 ggc agt gtg aat atc aca gac gac tgc cag aag cct cag ctg cac aac     1886
 Gly Ser Val Asn Ile Thr Asp Asp Cys Gln Lys Pro Gln Leu His Asn
         590                 595                 600

 ccc tcg agg ctg cga acg agg ctc ctc acc cca cag ggg ccc ttc tcc     1934
 Pro Ser Arg Leu Arg Thr Arg Leu Leu Thr Pro Gln Gly Pro Phe Ser
     605                 610                 615

 cag gct gtg ctg gac ata ttc acc tcc cgc ttc act tcc gcc cag agc     1982
 Gln Ala Val Leu Asp Ile Phe Thr Ser Arg Phe Thr Ser Ala Gln Ser
 620                 625                 630                 635

 ttt aac ttc acc cgg ggt ctc tgc ttg cac aag gac tat gtg gct ggc     2030
 Phe Asn Phe Thr Arg Gly Leu Cys Leu His Lys Asp Tyr Val Ala Gly
                 640                 645                 650

 agg gag ttc gtg gcc tgg aaa gac aca cac ccg gac gcc ttc ccc aac     2078
 Arg Glu Phe Val Ala Trp Lys Asp Thr His Pro Asp Ala Phe Pro Asn
             655                 660                 665

 cag ctc acc ccc atg cgg gac tgc ctg tac ctg gtg gac gga ggc ttt     2126
 Gln Leu Thr Pro Met Arg Asp Cys Leu Tyr Leu Val Asp Gly Gly Phe
         670                 675                 680

 gcc atc aac tct ccg ttc cca ctg gct ctg ctg cct cag aga gca gtg     2174
 Ala Ile Asn Ser Pro Phe Pro Leu Ala Leu Leu Pro Gln Arg Ala Val
     685                 690                 695

 gac ctc att ctg tcc ttt gac tat tcc ttg gaa gcc cct ttt gag gtc     2222
 Asp Leu Ile Leu Ser Phe Asp Tyr Ser Leu Glu Ala Pro Phe Glu Val
 700                 705                 710                 715

 ttg aag atg aca gag aag tac tgc ctg gac cga gga atc ccc ttc cct     2270
 Leu Lys Met Thr Glu Lys Tyr Cys Leu Asp Arg Gly Ile Pro Phe Pro
                 720                 725                 730

 agc atc gag gtg ggc cct gag gac gtg gag gag gcc cgt gag tgc tat     2318
 Ser Ile Glu Val Gly Pro Glu Asp Val Glu Glu Ala Arg Glu Cys Tyr
             735                 740                 745

 ctg ttt gcc aag gct gag gac ccc cgc tcc ccc att gtg ctg cac ttc     2366
 Leu Phe Ala Lys Ala Glu Asp Pro Arg Ser Pro Ile Val Leu His Phe
         750                 755                 760

 ccc ctg gtt aac cgt acc ttc cgc aca cac ctg gcc cca ggt gtg gag     2414
 Pro Leu Val Asn Arg Thr Phe Arg Thr His Leu Ala Pro Gly Val Glu
     765                 770                 775

 cga caa aca gct gag gag aag gcc ttt ggg gac ttt gtc atc aac agg     2462
 Arg Gln Thr Ala Glu Glu Lys Ala Phe Gly Asp Phe Val Ile Asn Arg
 780                 785                 790                 795

 cca gac acc ccc tat ggc atg atg aac ttc acc tat gag ccc cag gac     2510
 Pro Asp Thr Pro Tyr Gly Met Met Asn Phe Thr Tyr Glu Pro Gln Asp
                 800                 805                 810

 ttt tat cgg ctg gtg gcc ctc agt cga tac aac gtc ctg aac aac gtg     2558
 Phe Tyr Arg Leu Val Ala Leu Ser Arg Tyr Asn Val Leu Asn Asn Val
             815                 820                 825

 gag acc ttg aag tgc gcc ctc cag ctg gct ctg gac cgg cac cag gct     2606
 Glu Thr Leu Lys Cys Ala Leu Gln Leu Ala Leu Asp Arg His Gln Ala
         830                 835                 840

 cgg gag agg gca ggg gcc tga cc aaggcaggaa gcggaggact gtgacagaga     2659
 Arg Glu Arg Ala Gly Ala 
     845

 ggagacacac tgctcatggt cagggcttgt agagggagga gcgatgggga ctctgtgcag   2719

 gatctgcttc ccttctctcc aggacctgcc tcgaggtgcc ccaggccccg gaaagctctt   2779

 gcagaattgc agcttggact ggggcagggc tctccttgtg tgtttttgga gaagatgggc   2839

 agtagatcgc tccagggact cttggggatg tagggcagaa gagaacagca ctcatttcac   2899

 aaaaaaaaaa aaaaa                                                    2914




      <210> 165
      <211> 1645
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(662)

      <400> 165
 cggggcggcg ggggcgattg gacttggtgg gtcccgggcc aggggcgggc gccgcc         56                                                                 
 atg ggt aac ctg ttc ggc cgc aag aag cag agc cgc gtc acg gag cag      104
 Met Gly Asn Leu Phe Gly Arg Lys Lys Gln Ser Arg Val Thr Glu Gln
   1               5                  10                  15

 gac aag gcc atc ctg caa ctg aag cag cag cgg gac aag ctg agg cag      152
 Asp Lys Ala Ile Leu Gln Leu Lys Gln Gln Arg Asp Lys Leu Arg Gln
              20                  25                  30

 tac cag aag agg atc gcc cag cag ctg gag cgc gag cgc gcc ctg gcc      200
 Tyr Gln Lys Arg Ile Ala Gln Gln Leu Glu Arg Glu Arg Ala Leu Ala
          35                  40                  45

 cgg cag ctg ctg cgg gac ggc agg aag gaa cgg gcc aag ctg ctg ctc      248
 Arg Gln Leu Leu Arg Asp Gly Arg Lys Glu Arg Ala Lys Leu Leu Leu
      50                  55                  60

 aag aag aag cga tac cag gag cag ctc ctg gac agg acg gag aac cag      296
 Lys Lys Lys Arg Tyr Gln Glu Gln Leu Leu Asp Arg Thr Glu Asn Gln
  65                  70                  75                  80

 atc agc agc ctg gag gcc atg gtt cag agt att gag ttc acc cag atc      344
 Ile Ser Ser Leu Glu Ala Met Val Gln Ser Ile Glu Phe Thr Gln Ile
                  85                  90                  95

 gaa atg aaa gtg atg gag ggg ctg cag ttt gga aat gag tgt ctg aac      392
 Glu Met Lys Val Met Glu Gly Leu Gln Phe Gly Asn Glu Cys Leu Asn
             100                 105                 110

 aag atg cac cag gtg atg tcc att gaa gag gtg gag agg atc ctg gac      440
 Lys Met His Gln Val Met Ser Ile Glu Glu Val Glu Arg Ile Leu Asp
         115                 120                 125

 gag acg cag gag gcc gtg gag tac cag cgg caa ata gac gag ctc ctg      488
 Glu Thr Gln Glu Ala Val Glu Tyr Gln Arg Gln Ile Asp Glu Leu Leu
     130                 135                 140

 gca gga agc ttc act cag gag gat gaa gac gcc atc ctg gag gag ctg      536
 Ala Gly Ser Phe Thr Gln Glu Asp Glu Asp Ala Ile Leu Glu Glu Leu
 145                 150                 155                 160

 agc gca atc act cag gaa caa ata gag ctg cca gag gtt ccc tcc gag      584
 Ser Ala Ile Thr Gln Glu Gln Ile Glu Leu Pro Glu Val Pro Ser Glu
                 165                 170                 175

 ccc ctt cct gag aag atc cca gaa aac gtc cct gtc aag gcc agg ccc      632
 Pro Leu Pro Glu Lys Ile Pro Glu Asn Val Pro Val Lys Ala Arg Pro
             180                 185                 190

 agg cag gcg gag ctg gtg gca gct tcg taa c gtggcctcgt cttgtgggac      683
 Arg Gln Ala Glu Leu Val Ala Ala Ser 
         195                 200

 tcacggggat gccccaggga ctgtggccca cagagagttt gggtcacggc cagcccctga    743

 ccgggttccc tggagcccag tgcgcacggt gctgagcaga gctgcagcca cgcaggcgca    803

 ttgcaggagg actccagagc gtctcctgga gaccttgagc ctgaacgcac tcaggcgcca    863

 ctggcctgct ctcagtccgg attaactctc gaccgagccc agcttctgcc ggatgtgggc    923

 tcctccggtg gccgaggccc aggcccaacg cctctggtgc tgttcccctg cagtcccagc    983

 cccgcgtggc tcgcgctcgt ctgtgaggaa gacacctcca gaccttgggg tccccgcgct   1043

 tcctcttgct cctcgctgct cccattagct ggtgcaggct tccgttaagg ggtccctccc   1103

 ttggcctggc ttcccggcgc acctcagctt ccctgctggt ggggggatcc ccaggagacc   1163

 agcatgtgct gaacctctct gtgcctctgc ctccgcaccc tagacaccca cctccagttt   1223

 gaaggtggcg ggccaggggc tttcttgctg aattgacgac tccgagagcc ctgactcccg   1283

 ccttgccact cacggctctg tccactaggg ctcagccctg ctgagaaagg acctccgatg   1343

 cttgggagac gctgctccgg caggtgcagc cccggaagtt tgtccatggg ggtccccgcg   1403

 gctggggctc atggaactgc gagacccggg accctcctgc cctgcgggtc cccgagccac   1463

 cagcagccag gaccggaggc tgtggggcat ggcgtgactt ctcgtgcaca gggctggttt   1523

 ggttatgaga cgatctcgct gggaccgccc ctgcccgtgg aaagccacaa ggacaaaggg   1583

 agcggccacc tcgaccccca gacaggccgg cccgtattaa agttggccct gcaaaaaaaa   1643

 aa                                                                  1645




      <210> 166
      <211> 720
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (323)..(691)

      <400> 166
 gcttaaaaag aggccgattt catctcaaac cctggtgcag aggtcctagg cagagtggga     60

 aacttgccct ggagaagcag aagcagagac caaatggcta tctagtaagg atgttttata    120

 atgaatcctt cattccttta aagagcccat tattttctga ggcttcatgg gatgcgtaat    180

 agcccatgcc ttcactgcta agcataaaac atggagctct tagtagcctc taagacaatc    240

 atcgtcattc ccacgattgc cttcatcaag gccaggtact aaagaagtgc tcaagaaata    300

 cacatttctg atacaacagc tg atg tat ttt tat ccc att tat aga atg agt     352
                          Met Tyr Phe Tyr Pro Ile Tyr Arg Met Ser
                            1               5                  10

 gag atg ata ttt cga aga ata aag atg ccc tgg ctt tgg ctt gat ctc      400
 Glu Met Ile Phe Arg Arg Ile Lys Met Pro Trp Leu Trp Leu Asp Leu
                  15                  20                  25

 tgg tac ctt atg ttt aaa gaa gga tgg gaa cac aaa aag agc ctt cag      448
 Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys Ser Leu Gln
              30                  35                  40

 atc cta cat act ttt acc aac agt gtc atc gcg gaa cgg gcc aat gaa      496
 Ile Leu His Thr Phe Thr Asn Ser Val Ile Ala Glu Arg Ala Asn Glu
          45                  50                  55

 atg aac gcc aat gaa gac tgt aga ggt gat ggc agg ggc tct gcc ccc      544
 Met Asn Ala Asn Glu Asp Cys Arg Gly Asp Gly Arg Gly Ser Ala Pro
      60                  65                  70

 tcc aaa aat aaa cgc agg gcc ttt ctt gac ttg ctt tta agt gtg act      592
 Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu Ser Val Thr
  75                  80                  85                  90

 gat gac gaa ggg aac agg cta agt cat gaa gat att cga gaa gaa gtt      640
 Asp Asp Glu Gly Asn Arg Leu Ser His Glu Asp Ile Arg Glu Glu Val
                  95                 100                 105

 gac acc ttc atg ttt gag gta ttg tat att gtt agg ttc aga tat cat      688
 Asp Thr Phe Met Phe Glu Val Leu Tyr Ile Val Arg Phe Arg Tyr His
             110                 115                 120

 taa acaaatttca gttaaaaaaa aaaaaaaag                                  720
 






      <210> 167
      <211> 1525
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(1525)

      <400> 167
 gtgc atg tgg gca gct gag gcc tgg gtc agg ggc act gca cct cgg ccc      49
      Met Trp Ala Ala Glu Ala Trp Val Arg Gly Thr Ala Pro Arg Pro
        1               5                  10                  15

 ctc tgc tca tct tgg gca ggt gac cca ggt gga gct cag gcc cga ggc       97
 Leu Cys Ser Ser Trp Ala Gly Asp Pro Gly Gly Ala Gln Ala Arg Gly
                  20                  25                  30

 ccc cca aag atg gcg gac aag gtg gtc cca cgg cag gtg gcc cgg ctg      145
 Pro Pro Lys Met Ala Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu
              35                  40                  45

 ggc cgc act gtg cgg ctg cag tgc cca gtg gag ggg gac ccg ccg ccg      193
 Gly Arg Thr Val Arg Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro
          50                  55                  60

 ctg acc atg tgg acc aag gat ggc cgc acc atc cac agc ggc tgg agc      241
 Leu Thr Met Trp Thr Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser
      65                  70                  75

 cgc ttc cgc gtg ctg ccg cag ggg ctg aag gtg aag cag gtg gag cgg      289
 Arg Phe Arg Val Leu Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg
  80                  85                  90                  95

 gag gat gcc ggc gtg tac gtg tgc aag gcc acc aac ggc ttc ggc agc      337
 Glu Asp Ala Gly Val Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser
                 100                 105                 110

 ctg agc gtc aac tac acc ctc gtc gtg ctg gat gac att agc cca ggg      385
 Leu Ser Val Asn Tyr Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly
             115                 120                 125

 aag gag agc ctg ggg ccc gac agc tcc tct ggg ggt caa gag gac ccc      433
 Lys Glu Ser Leu Gly Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro
         130                 135                 140

 gcc agc cag cag tgg gca cga ccg cgc ttc aca cag ccc tcc aag atg      481
 Ala Ser Gln Gln Trp Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met
     145                 150                 155

 agg cgc cgg gtg atc gca cgg ccc gtg ggt agc tcc gtg cgg ctc aag      529
 Arg Arg Arg Val Ile Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys
 160                 165                 170                 175

 tgc gtg gcc agc ggg cac cct cgg ccc gac atc acg tgg atg aag gac      577
 Cys Val Ala Ser Gly His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp
                 180                 185                 190

 gac cag gcc ttg acg cgc cca gag gcc gct gag ccc agg aag aag aag      625
 Asp Gln Ala Leu Thr Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys
             195                 200                 205

 tgg aca ctg agc ctg aag aac ctg cgg ccg gag gac agc ggc aaa tac      673
 Trp Thr Leu Ser Leu Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr
         210                 215                 220

 acc tgc cgc gtg tcg aac cgc gcg ggc gcc atc aac gcc acc tac aag      721
 Thr Cys Arg Val Ser Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys
     225                 230                 235

 gtg gat gtg atc cag cgg acc cgt tcc aag ccc gtg ctc aca ggc acg      769
 Val Asp Val Ile Gln Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr
 240                 245                 250                 255

 cac ccc gtg aac acg acg gtg gac ttc ggg ggg acc acg tcc ttc cag      817
 His Pro Val Asn Thr Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln
                 260                 265                 270

 tgc aag gtg cgc agc gac gtg aag ccg gtg atc cag tgg ctg aag cgc      865
 Cys Lys Val Arg Ser Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg
             275                 280                 285

 gtg gag tac ggc gcc gag ggc cgc cac aac tcc acc atc gat gtg ggc      913
 Val Glu Tyr Gly Ala Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly
         290                 295                 300

 ggc cag aag ttt gtg gtg ctg ccc acg ggt gac gtg tgg tcg cgg ccc      961
 Gly Gln Lys Phe Val Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro
     305                 310                 315

 gac ggc tcc tac ctc aat aag ctg ctc atc acc cgt gcc cgc cag gac     1009
 Asp Gly Ser Tyr Leu Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp
 320                 325                 330                 335

 gat gcg ggc atg tac atc tgc ctt ggc gcc aac acc atg ggc tac agc     1057
 Asp Ala Gly Met Tyr Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser
                 340                 345                 350

 ttc cgc agc gcc ttc ctc acc gtg ctg cca gac cca aaa ccg cca ggg     1105
 Phe Arg Ser Ala Phe Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly
             355                 360                 365

 cca cct gtg gcc tcc tcg tcc tcg gcc act agc ctg ccg tgg ccc gtg     1153
 Pro Pro Val Ala Ser Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val
         370                 375                 380

 gtc atc ggc atc cca gcc ggc gct gtc ttc atc ctg ggc acc ctg ctc     1201
 Val Ile Gly Ile Pro Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu
     385                 390                 395

 ctg tgg ctt tgc cag gcc cag aag aag ccg tgc acc ccc gcg cct gcc     1249
 Leu Trp Leu Cys Gln Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala
 400                 405                 410                 415

 cct ccc ctg cct ggg cac cgc ccg ccg ggg acg gcc cgc gac cgc agc     1297
 Pro Pro Leu Pro Gly His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser
                 420                 425                 430

 gga gac aag gac ctt ccc tcg ttg gcc gcc ctc agc gct ggc cct ggt     1345
 Gly Asp Lys Asp Leu Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly
             435                 440                 445

 gtg ggg ctg tgt gag gag cat ggg tct ccg gca gcc ccc cag cac tta     1393
 Val Gly Leu Cys Glu Glu His Gly Ser Pro Ala Ala Pro Gln His Leu
         450                 455                 460

 ctg ggc cca ggc cca gtt gct ggc cct aag ttg tac ccc aaa ctc tac     1441
 Leu Gly Pro Gly Pro Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr
     465                 470                 475

 aca gac atc cac aca cac aca tac aca cac ccc cac ctc ctg caa tta     1489
 Thr Asp Ile His Thr His Thr Tyr Thr His Pro His Leu Leu Gln Leu
 480                 485                 490                 495

 aac agt agc atc aca aaa aat aaa aaa aaa aaa taa                     1525
 Asn Ser Ser Ile Thr Lys Asn Lys Lys Lys Lys 
                 500                 505





      <210> 168
      <211> 3375
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (150)..(1664)

      <400> 168
 gccgccccgc cccgagaccg ggcccggggg cgcggggcgg cgggatgcgg cgcccggggc     60

 ggcgatgacc gcggagcgca cgccgcgggc ccggccctga ccccgccgcc cgcccgctga    120

 gccccccgcc gaggtccgga caggccgag  atg acg ccg agc ccc ctg ttg ctg     173
                                  Met Thr Pro Ser Pro Leu Leu Leu
                                    1               5

 ctc ctg ctg ccg ccg ctg ctg ctg ggg gcc ttc cca ccg gcc gcc gcc      221
 Leu Leu Leu Pro Pro Leu Leu Leu Gly Ala Phe Pro Pro Ala Ala Ala
      10                  15                  20

 gcc cga ggc ccc cca aag atg gcg gac aag gtg gtc cca cgg cag gtg      269
 Ala Arg Gly Pro Pro Lys Met Ala Asp Lys Val Val Pro Arg Gln Val
  25                  30                  35                  40

 gcc cgg ctg ggc cgc act gtg cgg ctg cag tgc cca gtg gag ggg gac      317
 Ala Arg Leu Gly Arg Thr Val Arg Leu Gln Cys Pro Val Glu Gly Asp
                  45                  50                  55

 ccg ccg ccg ctg acc atg tgg acc aag gat ggc cgc acc atc cac agc      365
 Pro Pro Pro Leu Thr Met Trp Thr Lys Asp Gly Arg Thr Ile His Ser
              60                  65                  70

 ggc tgg agc cgc ttc cgc gtg ctg ccg cag ggg ctg aag gtg aag cag      413
 Gly Trp Ser Arg Phe Arg Val Leu Pro Gln Gly Leu Lys Val Lys Gln
          75                  80                  85

 gtg gag cgg gag gat gcc ggc gtg tac gtg tgc aag gcc acc aac ggc      461
 Val Glu Arg Glu Asp Ala Gly Val Tyr Val Cys Lys Ala Thr Asn Gly
      90                  95                 100

 ttc ggc agc ctg agc gtc aac tac acc ctc gtc gtg ctg gat gac att      509
 Phe Gly Ser Leu Ser Val Asn Tyr Thr Leu Val Val Leu Asp Asp Ile
 105                 110                 115                 120

 agc cca ggg aag gag agc ctg ggg ccc gac agc tcc tct ggg ggt caa      557
 Ser Pro Gly Lys Glu Ser Leu Gly Pro Asp Ser Ser Ser Gly Gly Gln
                 125                 130                 135

 gag gac ccc gcc agc cag cag tgg gca cga ccg cgc ttc aca cag ccc      605
 Glu Asp Pro Ala Ser Gln Gln Trp Ala Arg Pro Arg Phe Thr Gln Pro
             140                 145                 150

 tcc aag atg agg cgc cgg gtg atc gca cgg ccc gtg ggt agc tcc gtg      653
 Ser Lys Met Arg Arg Arg Val Ile Ala Arg Pro Val Gly Ser Ser Val
         155                 160                 165

 cgg ctc aag tgc gtg gcc agc ggg cac cct cgg ccc gac atc acg tgg      701
 Arg Leu Lys Cys Val Ala Ser Gly His Pro Arg Pro Asp Ile Thr Trp
     170                 175                 180

 atg aag gac gac cag gcc ttg acg cgc cca gag gcc gct gag ccc agg      749
 Met Lys Asp Asp Gln Ala Leu Thr Arg Pro Glu Ala Ala Glu Pro Arg
 185                 190                 195                 200

 aag aag aag tgg aca ctg agc ctg aag aac ctg cgg ccg gag gac agc      797
 Lys Lys Lys Trp Thr Leu Ser Leu Lys Asn Leu Arg Pro Glu Asp Ser
                 205                 210                 215

 ggc aaa tac acc tgc cgc gtg tcg aac cgc gcg ggc gcc atc aac gcc      845
 Gly Lys Tyr Thr Cys Arg Val Ser Asn Arg Ala Gly Ala Ile Asn Ala
             220                 225                 230

 acc tac aag gtg gat gtg atc cag cgg acc cgt tcc aag ccc gtg ctc      893
 Thr Tyr Lys Val Asp Val Ile Gln Arg Thr Arg Ser Lys Pro Val Leu
         235                 240                 245

 aca ggc acg cac ccc gtg aac acg acg gtg gac ttc ggg ggg acc acg      941
 Thr Gly Thr His Pro Val Asn Thr Thr Val Asp Phe Gly Gly Thr Thr
     250                 255                 260

 tcc ttc cag tgc aag gtg cgc agc gac gtg aag ccg gtg atc cag tgg      989
 Ser Phe Gln Cys Lys Val Arg Ser Asp Val Lys Pro Val Ile Gln Trp
 265                 270                 275                 280

 ctg aag cgc gtg gag tac ggc gcc gag ggc cgc cac aac tcc acc atc     1037
 Leu Lys Arg Val Glu Tyr Gly Ala Glu Gly Arg His Asn Ser Thr Ile
                 285                 290                 295

 gat gtg ggc ggc cag aag ttt gtg gtg ctg ccc acg ggt gac gtg tgg     1085
 Asp Val Gly Gly Gln Lys Phe Val Val Leu Pro Thr Gly Asp Val Trp
             300                 305                 310

 tcg cgg ccc gac ggc tcc tac ctc aat aag ctg ctc atc acc cgt gcc     1133
 Ser Arg Pro Asp Gly Ser Tyr Leu Asn Lys Leu Leu Ile Thr Arg Ala
         315                 320                 325

 cgc cag gac gat gcg ggc atg tac atc tgc ctt ggc gcc aac acc atg     1181
 Arg Gln Asp Asp Ala Gly Met Tyr Ile Cys Leu Gly Ala Asn Thr Met
     330                 335                 340

 ggc tac agc ttc cgc agc gcc ttc ctc acc gtg ctg cca gac cca aaa     1229
 Gly Tyr Ser Phe Arg Ser Ala Phe Leu Thr Val Leu Pro Asp Pro Lys
 345                 350                 355                 360

 ccg cca ggg cca cct gtg gcc tcc tcg tcc tcg gcc act agc ctg ccg     1277
 Pro Pro Gly Pro Pro Val Ala Ser Ser Ser Ser Ala Thr Ser Leu Pro
                 365                 370                 375

 tgg ccc gtg gtc atc ggc atc cca gcc ggc gct gtc ttc atc ctg ggc     1325
 Trp Pro Val Val Ile Gly Ile Pro Ala Gly Ala Val Phe Ile Leu Gly
             380                 385                 390

 acc ctg ctc ctg tgg ctt tgc cag gcc cag aag aag ccg tgc acc ccc     1373
 Thr Leu Leu Leu Trp Leu Cys Gln Ala Gln Lys Lys Pro Cys Thr Pro
         395                 400                 405

 gcg cct gcc cct ccc ctg cct ggg cac cgc ccg ccg ggg acg gcc cgc     1421
 Ala Pro Ala Pro Pro Leu Pro Gly His Arg Pro Pro Gly Thr Ala Arg
     410                 415                 420

 gac cgc agc gga gac aag gac ctt ccc tcg ttg gcc gcc ctc agc gct     1469
 Asp Arg Ser Gly Asp Lys Asp Leu Pro Ser Leu Ala Ala Leu Ser Ala
 425                 430                 435                 440

 ggc cct ggt gtg ggg ctg tgt gag gag cat ggg tct ccg gca gcc ccc     1517
 Gly Pro Gly Val Gly Leu Cys Glu Glu His Gly Ser Pro Ala Ala Pro
                 445                 450                 455

 cag cac tta ctg ggc cca ggc cca gtt gct ggc cct aag ttg tac ccc     1565
 Gln His Leu Leu Gly Pro Gly Pro Val Ala Gly Pro Lys Leu Tyr Pro
             460                 465                 470

 aaa ctc tac aca gac atc cac aca cac aca cac aca cac tct cac aca     1613
 Lys Leu Tyr Thr Asp Ile His Thr His Thr His Thr His Ser His Thr
         475                 480                 485

 cac tca cac gtg gag ggc aag gtc cac cag cac atc cac tat cag tgc     1661
 His Ser His Val Glu Gly Lys Val His Gln His Ile His Tyr Gln Cys
     490                 495                 500

 tag acgg caccgtatct gcagtgggca cgggggggcc ggccagacag gcagactggg     1718
 


 aggatggagg acggagctgc agacgaaggc aggggaccca tggcgaggag gaatggccag   1778

 caccccaggc agtctgtgtg tgaggcatag cccctggaca cacacacaca gacacacaca   1838

 ctacctggat gcatgtatgc acacacatgc gcgcacacgt gctccctgaa ggcacacgta   1898

 cgcacacacg cacatgcaca gatatgccgc ctgggcacac agataagctg cccaaatgca   1958

 cgcacacgca cagagacatg ccagaacata caaggacatg ctgcctgaac atacacacgc   2018

 acacccatgc gcagatgtgc tgcctggaca cacacacaca cacggatatg ctgtctggac   2078

 gcacacacgt gcagatatgg tatccggaca cacacgtgca cagatatgct gcctggacac   2138

 acagataatg ctgccttgac acacacatgc acggatattg cctggacaca cacacacaca   2198

 cgcgtgcaca gatatgctgt ctggacacgc acacacatgc agatatgctg cctggacaca   2258

 cacttccaga cacacgtgca caggcgcaga tatgctgcct ggacacacgc agatatgctg   2318

 tctagtcaca cacacacgca gacatgctgt ccggacacac acacgcatgc acagatatgc   2378

 tgtccggaca cacacacgca cgcagatatg ctgcctggac acacacacag ataatgctgc   2438

 ctcaacactc acacacgtgc agatattgcc tggacacaca catgtgcaca gatatgctgt   2498

 ctggacatgc acacacgtgc agatatgctg tccggataca cacgcacgca cacatgcaga   2558

 tatgctgcct gggcacacac ttccggacac acatgcacac acaggtgcag atatgctgcc   2618

 tggacacacg cagactgacg tgcttttggg agggtgtgcc gtgaagcctg cagtacgtgt   2678

 gccgtgaggc tcatagttga tgagggactt tccctgctcc accgtcactc ccccaactct   2738

 gcccgcctct gtccccgcct cagtccccgc ctccatcccc gcctctgtcc cctggccttg   2798

 gcggctattt ttgccacctg ccttgggtgc ccaggagtcc cctactgctg tgggctgggg   2858

 ttgggggcac agcagcccca agcctgagag gctggagccc atggctagtg gctcatcccc   2918

 actgcattct ccccctgaca cagagaaggg gccttggtat ttatatttaa gaaatgaaga   2978

 taatattaat aatgatggaa ggaagactgg gttgcaggga ctgtggtctc tcctggggcc   3038

 cgggacccgc ctggtctttc agccatgctg atgaccacac cccgtccagg cagaaacaac   3098

 cccaccatgt cgtgctggcc cagatccccg taattaatgt agaggtgagc tgaagcccgt   3158

 atattagtta ttcggtaaac atgaagtgct ctttcaaaaa gacacaaaca cacaaaaaaa   3218

 agggggggca aaaatccggg gggcaagatg cgcacccttt ctgacagggc caagagggta   3278

 aagcacaggc gcgttaacgc gggaaagcgc gggttgggac cctctggggg tgggcaccac   3338

 ataccgagaa agttgtcgcc gcgggtgaca acaaaac                            3375




      <210> 169
      <211> 3182
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(422)

      <400> 169
 gcggccgcga ccccaggtcc ggacaggccg ag  atg acg ccg agc ccc ctg ttg      53
                                      Met Thr Pro Ser Pro Leu Leu
                                        1               5

 ctg ctc ctg ctg ccg ccg ctg ctg ctg ggg gcc ttc cca ccg gcc gcc      101
 Leu Leu Leu Leu Pro Pro Leu Leu Leu Gly Ala Phe Pro Pro Ala Ala
          10                  15                  20

 gcc gcc cga ggc ccc cca aag atg gcg gac aag gtg gtc cca cgg cag      149
 Ala Ala Arg Gly Pro Pro Lys Met Ala Asp Lys Val Val Pro Arg Gln
      25                  30                  35

 gtg gcc cgg ctg ggc cgc act gtg cgg ctg cag tgc cca gtg gag ggg      197
 Val Ala Arg Leu Gly Arg Thr Val Arg Leu Gln Cys Pro Val Glu Gly
  40                  45                  50                  55

 gac ccg ccg ccg ctg acc atg tgg acc aag gat ggc cgc acc atc cac      245
 Asp Pro Pro Pro Leu Thr Met Trp Thr Lys Asp Gly Arg Thr Ile His
                  60                  65                  70

 agc ggc tgg agc cgc ttc cgc gtg ctg ccg cag ggg ctg aag gtg aag      293
 Ser Gly Trp Ser Arg Phe Arg Val Leu Pro Gln Gly Leu Lys Val Lys
              75                  80                  85

 cag gtg gag cgg gag gat gcc ggc gtg tac gtg tgc aag gcc acc aac      341
 Gln Val Glu Arg Glu Asp Ala Gly Val Tyr Val Cys Lys Ala Thr Asn
          90                  95                 100

 ggc ttc ggc agc ctg agc gtc aag agg acc ccg cca gcc agc agt ggg      389
 Gly Phe Gly Ser Leu Ser Val Lys Arg Thr Pro Pro Ala Ser Ser Gly
     105                 110                 115

 cac gac cgc gct tca cac agc cct cca aga tga ggcgccgg gtgatcgcac      440
 His Asp Arg Ala Ser His Ser Pro Pro Arg 
 120                 125

 ggcccgtggg tagctccgtg cggctcaagt gcgtggccag cgggcaccct cggcccgaca    500

 tcacgtggat gaaggacgac caggccttga cgcgcccaga ggccgctgag cccaggaaga    560

 agaagtggac actgagcctg aagaacctgc ggccggagga cagcggcaaa tacacctgcc    620

 gcgtgtcgaa ccgcgcgggc gccatcaacg ccacctacaa ggtggatgtg atccagcgga    680

 cccgttccaa gcccgtgctc acaggcacgc accccgtgaa cacgacggtg gacttcgggg    740

 ggaccacgtc cttccagtgc aaggtgcgca gcgacgtgaa gccggtgatc cagtggctga    800

 agcgcgtgga gtacggcgcc gagggccgcc acaactccac catcgatgtg ggcggccaga    860

 agtttgtggt gctgcccacg ggtgacgtgt ggtcgcggcc cgacggctcc tacctcaata    920

 agctgctcat cacccgtgcc cgccaggacg atgcgggcat gtacatctgc cttggcgcca    980

 acaccatggg ctacagcttc cgcagcgcct tcctcaccgt gctgccagac ccaaaaccgc   1040

 cagggccacc tgtggcctcc tcgtcctcgg ccactagcct gccgtggccc gtggtcatcg   1100

 gcatcccagc cggcgctgtc ttcatcctgg gcaccctgct cctgtggctt tgccaggccc   1160

 agaagaagcc gtgcaccccc gcgcctgccc ctcccctgcc tgggcaccgc ccgccgggga   1220

 cggcccgcga ccgcagcgga gacaaggacc ttccctcgtt ggccgccctc agcgctggcc   1280

 ctggtgtggg gctgtgtgag gagcatgggt ctccggcagc cccccagcac ttactgggcc   1340

 caggcccagt tgctggccct aagttgtacc ccaaactcta cacagacatc cacacacaca   1400

 cacacacaca ctctcacaca cactcacacg tggagggcaa ggtccaccag cacatccact   1460

 atcagtgcta gacggcaccg tatctgcagt gggcacgggg gggccggcca gacaggcaga   1520

 ctgggaggat ggaggacgga gctgcagacg aaggcagggg acccatggcg aggaggaatg   1580

 gccagcaccc caggcagtct gtgtgtgagg catagcccct ggacacacac acacagacac   1640

 acacactacc tggatgcatg tatgcacaca catgcgcgca cacgtgctcc ctgaaggcac   1700

 acgtacgcac acacgcacat gcacagatat gccgcctggg cacacagata agctgcccaa   1760

 atgcacgcac acgcacagag acatgccaga acatacaagg acatgctgcc tgaacataca   1820

 cacgcacacc catgcgcaga tgtgctgcct ggacacacac acacacacgg atatgctgtc   1880

 tggacgcaca cacgtgcaga tatggtatcc ggacacacac gtgcacagat atgctgcctg   1940

 gacacacaga taatgctgcc ttgacacaca catgcacgga tattgcctgg acacacacac   2000

 acacacgcgt gcacagatat gctgtctgga cacgcacaca catgcagata tgctgcctgg   2060

 acacacactt ccagacacac gtgcacaggc gcagatatgc tgcctggaca cacgcagata   2120

 tgctgtctag tcacacacac acgcagacat gctgtccgga cacacacacg catgcacaga   2180

 tatgctgtcc ggacacacac acgcacgcag atatgctgcc tggacacaca cacagataat   2240

 gctgcctcaa cactcacaca cgtgcagata ttgcctggac acacacatgt gcacagatat   2300

 gctgtctgga catgcacaca cgtgcagata tgctgtccgg atacacacgc acgcacacat   2360

 gcagatatgc tgcctgggca cacacttccg gacacacatg cacacacagg tgcagatatg   2420

 ctgcctggac acacgcagac tgacgtgctt ttgggagggt gtgccgtgaa gcctgcagta   2480

 cgtgtgccgt gaggctcata gttgatgagg gactttccct gctccaccgt cactccccca   2540

 actctgcccg cctctgtccc cgcctcagtc cccgcctcca tccccgcctc tgtcccctgg   2600

 ccttggcggc tatttttgcc acctgccttg ggtgcccagg agtcccctac tgctgtgggc   2660

 tggggttggg ggcacagcag ccccaagcct gagaggctgg agcccatggc tagtggctca   2720

 tccccactgc attctccccc tgacacagag aaggggcctt ggtatttata tttaagaaat   2780

 gaagataata ttaataatga tggaaggaag actgggttgc agggactgtg gtctctcctg   2840

 gggcccggga cccgcctggt ctttcagcca tgctgatgac cacaccccgt ccaggcagaa   2900

 acaaccccac catgtcgtgc tggcccagat ccccgtaatt aatgtagagg tgagctgaag   2960

 cccgtatatt agttattcgg taaacatgaa gtgctctttc aaaaagacac aaacacacaa   3020

 aaaaaagggg gggcaaaaat ccggggggca agatgcgcac cctttctgac agggccaaga   3080

 gggtaaagca caggcgcgtt aacgcgggaa agcgcgggtt gggaccctct gggggtgggc   3140

 accacatacc gagaaagttg tcgccgcggg tgacaacaaa ac                      3182




      <210> 170
      <211> 1812
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (19)..(1248)

      <400> 170
 tgactattaa gcgggata  atg cgt gtt atg cac ttg gca ccc ggg cct ggc      51
                      Met Arg Val Met His Leu Ala Pro Gly Pro Gly
                        1               5                  10

 agt ccc tcg gag ctc agg gcg ccc tcg cgc gac gtc ctg ctg gtc tct       99
 Ser Pro Ser Glu Leu Arg Ala Pro Ser Arg Asp Val Leu Leu Val Ser
              15                  20                  25

 gcc atc atc acc gtc agc ctt agc gtc act gtc gtc ctc tgc ggc ctc      147
 Ala Ile Ile Thr Val Ser Leu Ser Val Thr Val Val Leu Cys Gly Leu
          30                  35                  40

 tgc cac tgg tgt cag cgc aaa ctg ggc aaa cgc tac aag aat tcc ttg      195
 Cys His Trp Cys Gln Arg Lys Leu Gly Lys Arg Tyr Lys Asn Ser Leu
      45                  50                  55

 gag acg gtg ggc acg cca gac tca ggg cgt ggg cgc agt gag aag aag      243
 Glu Thr Val Gly Thr Pro Asp Ser Gly Arg Gly Arg Ser Glu Lys Lys
  60                  65                  70                  75

 gct atc aag ttg cct gca gga ggg aag gcg gtg aac aca gcc ccc gtg      291
 Ala Ile Lys Leu Pro Ala Gly Gly Lys Ala Val Asn Thr Ala Pro Val
                  80                  85                  90

 cca ggc cag aca ccc cac gat gag tcc gac cgc cgg acc gag cca cgt      339
 Pro Gly Gln Thr Pro His Asp Glu Ser Asp Arg Arg Thr Glu Pro Arg
              95                 100                 105

 tcc tcc gtc tca gac ctc gtc aac tcc ctc acc agc gag atg ctc atg      387
 Ser Ser Val Ser Asp Leu Val Asn Ser Leu Thr Ser Glu Met Leu Met
         110                 115                 120

 ctc tcc cca ggc tcc gag gag gat gag gcc cac gag ggt tgc agc cga      435
 Leu Ser Pro Gly Ser Glu Glu Asp Glu Ala His Glu Gly Cys Ser Arg
     125                 130                 135

 gag aac ctg ggc cgg atc cag ttc agt gtc ggc tac aac ttc cag gag      483
 Glu Asn Leu Gly Arg Ile Gln Phe Ser Val Gly Tyr Asn Phe Gln Glu
 140                 145                 150                 155

 tcc acg ctc acc ctg aag atc atg aag gcc cag gag ctg ccg gcc aag      531
 Ser Thr Leu Thr Leu Lys Ile Met Lys Ala Gln Glu Leu Pro Ala Lys
                 160                 165                 170

 gac ttc agc ggc acc agc gac ccc ttc gtc aag atc tac ctg ctg ccc      579
 Asp Phe Ser Gly Thr Ser Asp Pro Phe Val Lys Ile Tyr Leu Leu Pro
             175                 180                 185

 gac aag aag cac aag ctg aag acc aag gtg aag cgg aag aac cta aac      627
 Asp Lys Lys His Lys Leu Lys Thr Lys Val Lys Arg Lys Asn Leu Asn
         190                 195                 200

 ccc cac tgg aac gag acc ttc ctc ttt gaa ggt ttt ccc tat gag aag      675
 Pro His Trp Asn Glu Thr Phe Leu Phe Glu Gly Phe Pro Tyr Glu Lys
     205                 210                 215

 gtg gtg cag agg atc ctc tac ctc caa gtc ctg gac tat gac cgc ttc      723
 Val Val Gln Arg Ile Leu Tyr Leu Gln Val Leu Asp Tyr Asp Arg Phe
 220                 225                 230                 235

 agc cgc aac gac ccc att ggg gag gtg tcc atc ccc ctt aac aag gtg      771
 Ser Arg Asn Asp Pro Ile Gly Glu Val Ser Ile Pro Leu Asn Lys Val
                 240                 245                 250

 gac ctg acc cag atg cag acc ttc tgg aag gat ctg aag cca tgc agc      819
 Asp Leu Thr Gln Met Gln Thr Phe Trp Lys Asp Leu Lys Pro Cys Ser
             255                 260                 265

 gat ggg agt ggg agc cga ggg gag ctg ctc ttg tct ctc tgc tac aac      867
 Asp Gly Ser Gly Ser Arg Gly Glu Leu Leu Leu Ser Leu Cys Tyr Asn
         270                 275                 280

 ccc tct gcc aac tcc atc atc gtg aac atc atc aaa gcc cgg aac ctc      915
 Pro Ser Ala Asn Ser Ile Ile Val Asn Ile Ile Lys Ala Arg Asn Leu
     285                 290                 295

 aaa gcc atg gac atc ggg ggc aca tca gac ccc tac gtg aag gta tgg      963
 Lys Ala Met Asp Ile Gly Gly Thr Ser Asp Pro Tyr Val Lys Val Trp
 300                 305                 310                 315

 ctg atg tac aag gac aag cgg gtg gag aag aag aag acg gtg acg atg     1011
 Leu Met Tyr Lys Asp Lys Arg Val Glu Lys Lys Lys Thr Val Thr Met
                 320                 325                 330

 aag agg aac ctg aac ccc atc ttc aat gag tcc ttc gcc ttc gat atc     1059
 Lys Arg Asn Leu Asn Pro Ile Phe Asn Glu Ser Phe Ala Phe Asp Ile
             335                 340                 345

 ccc acg gag aag ctg agg gag acg acc atc atc atc act gtc atg gac     1107
 Pro Thr Glu Lys Leu Arg Glu Thr Thr Ile Ile Ile Thr Val Met Asp
         350                 355                 360

 aag gac aag ctc agc cgc aat gac gtc atc ggc aag atc tac ctg tcc     1155
 Lys Asp Lys Leu Ser Arg Asn Asp Val Ile Gly Lys Ile Tyr Leu Ser
     365                 370                 375

 tgg aag agc ggg cca ggg gag gtg aag cac tgg aag gac atg att gcc     1203
 Trp Lys Ser Gly Pro Gly Glu Val Lys His Trp Lys Asp Met Ile Ala
 380                 385                 390                 395

 cgt ccc cgg cag ccc gtg gcc cag tgg cac cag ctg aag gcc tga gtg     1251
 Arg Pro Arg Gln Pro Val Ala Gln Trp His Gln Leu Lys Ala 
                 400                 405

 gggccaaggg aggcccaggg ggccgagggc ccaggtcccc atcatgccct caccacttta   1311

 tgcacaacgc ccggcctgag ccccctgcca tagggagggg aggaccctga gggctcagcc   1371

 agggaggggt cccaggactc aactgggccc cgtttctagg aagtaccagc cccatccccc   1431

 acagtccagc tccggggaag gggctctggg aggcattttc ctgctttgcc ccttttcttc   1491

 ctgacttact aatactaaag aagttggggg agctcgagag ccagacggcc agacaggcag   1551

 acccctccag aggcccgcca ggtgggcatg gtcccccatt ttctttaagg cagcacctgg   1611

 agtggagaga ggccactccc tctccagccc ccgatgtgga cccggggagg ggaggctgag   1671

 gcgtttggcc ccggcctggc caggagaggc ccatccccag ggcagtttca ggtgccggct   1731

 gggccctgaa tgtcgaggat agtatatagc ccgctcctgg gtcctggagc tgtgagcgtt   1791

 tgtactcgta aaaaaaaaaa a                                             1812




      <210> 171
      <211> 5115
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (327)..(5108)

      <400> 171
 gaattccggg agcgggcggg ctgcgaggcc gcggggcatg cgggaggcgg aggggtggga     60

 ccgggtggct gcgcccattc cacacccgcc gaaagcggac actgtcagct gaatcactcc    120

 ccttttagga ggagggaggg ggaaaaggtg tctagctaat ttctgcttaa aaaagcacag    180

 gagatcgcgg gtcagctttg cagtcgctgc cttctcgcgc ctgaccatgc acccctgcat    240

 cttcctgctg ggcacaggcg agcgctttat ttctggagct gagggctaaa acttttttca    300

 cttttcttct cctcaacatc tgaatc atg cca tgt gcc cag agg agc tgg ctt     353
                              Met Pro Cys Ala Gln Arg Ser Trp Leu
                                1               5

 gca aac ctt tcc gtg gtg gct cag ctc ctt aac ttt ggg gcg ctt tgc      401
 Ala Asn Leu Ser Val Val Ala Gln Leu Leu Asn Phe Gly Ala Leu Cys
  10                  15                  20                  25

 tat ggg aga cag cct cag cca ggc ccg gtt cgc ttc ccg gac agg agg      449
 Tyr Gly Arg Gln Pro Gln Pro Gly Pro Val Arg Phe Pro Asp Arg Arg
                  30                  35                  40

 caa gag cat ttt atc aag ggc ctg cca gaa tac cac gtg gtg ggt cca      497
 Gln Glu His Phe Ile Lys Gly Leu Pro Glu Tyr His Val Val Gly Pro
              45                  50                  55

 gtc cga gta gat gcc agt ggg cat ttt ttg tca tat ggc ttg cac tat      545
 Val Arg Val Asp Ala Ser Gly His Phe Leu Ser Tyr Gly Leu His Tyr
          60                  65                  70

 ccc atc acg agc agc agg agg aag aga gat ttg gat ggc tca gag gac      593
 Pro Ile Thr Ser Ser Arg Arg Lys Arg Asp Leu Asp Gly Ser Glu Asp
      75                  80                  85

 tgg gtg tac tac aga att tct cac gag gag aag gac ctg ttt ttt aac      641
 Trp Val Tyr Tyr Arg Ile Ser His Glu Glu Lys Asp Leu Phe Phe Asn
  90                  95                 100                 105

 ttg acg gtc aat caa gga ttt ctt tcc aat agc tac atc atg gag aag      689
 Leu Thr Val Asn Gln Gly Phe Leu Ser Asn Ser Tyr Ile Met Glu Lys
                 110                 115                 120

 aga tat ggg aac ctc tcc cat gtt aag atg atg gct tcc tct gcc ccc      737
 Arg Tyr Gly Asn Leu Ser His Val Lys Met Met Ala Ser Ser Ala Pro
             125                 130                 135

 ctc tgc cat ctc agt ggc acg gtt cta cag cag ggc acc aga gtt ggg      785
 Leu Cys His Leu Ser Gly Thr Val Leu Gln Gln Gly Thr Arg Val Gly
         140                 145                 150

 acg gca gcc ctc agt gcc tgc cat gga ctg act gga ttt ttc caa cta      833
 Thr Ala Ala Leu Ser Ala Cys His Gly Leu Thr Gly Phe Phe Gln Leu
     155                 160                 165

 cca cat gga gac ttt ttc att gaa ccc gtg aag aag cat cca ctg gtt      881
 Pro His Gly Asp Phe Phe Ile Glu Pro Val Lys Lys His Pro Leu Val
 170                 175                 180                 185

 gag gga ggg tac cac ccg cac atc gtt tac agg agg cag aaa gtt cca      929
 Glu Gly Gly Tyr His Pro His Ile Val Tyr Arg Arg Gln Lys Val Pro
                 190                 195                 200

 gaa acc aag gag cca acc tgt gga tta aag gac agt gtt aac atc tcc      977
 Glu Thr Lys Glu Pro Thr Cys Gly Leu Lys Asp Ser Val Asn Ile Ser
             205                 210                 215

 cag aag caa gag cta tgg cgg gag aag tgg gag agg cac aac ttg cca     1025
 Gln Lys Gln Glu Leu Trp Arg Glu Lys Trp Glu Arg His Asn Leu Pro
         220                 225                 230

 agc aga agc ctc tct cgg cgt tcc atc agc aag gag aga tgg gtg gag     1073
 Ser Arg Ser Leu Ser Arg Arg Ser Ile Ser Lys Glu Arg Trp Val Glu
     235                 240                 245

 aca ctg gtg gtg gcc gac aca aag atg att gaa tac cat ggg agt gag     1121
 Thr Leu Val Val Ala Asp Thr Lys Met Ile Glu Tyr His Gly Ser Glu
 250                 255                 260                 265

 aat gtg gag tcc tac atc ctc acc atc atg aac atg gtc act ggg ttg     1169
 Asn Val Glu Ser Tyr Ile Leu Thr Ile Met Asn Met Val Thr Gly Leu
                 270                 275                 280

 ttc cat aac cca agc att ggc aat gca att cac att gtt gtg gtt cgg     1217
 Phe His Asn Pro Ser Ile Gly Asn Ala Ile His Ile Val Val Val Arg
             285                 290                 295

 ctc att cta ctc gaa gaa gaa gag caa gga ctg aaa ata gtt cac cat     1265
 Leu Ile Leu Leu Glu Glu Glu Glu Gln Gly Leu Lys Ile Val His His
         300                 305                 310

 gca gaa aag aca ctg tct agc ttc tgc aag tgg cag aag agt atc aat     1313
 Ala Glu Lys Thr Leu Ser Ser Phe Cys Lys Trp Gln Lys Ser Ile Asn
     315                 320                 325

 ccc aag agt gac ctc aat cct gtt cat cac gac gtg gct gtc ctt ctc     1361
 Pro Lys Ser Asp Leu Asn Pro Val His His Asp Val Ala Val Leu Leu
 330                 335                 340                 345

 acc aga aag gac atc tgt gct ggt ttc aat cgc ccc tgc gag acc ctg     1409
 Thr Arg Lys Asp Ile Cys Ala Gly Phe Asn Arg Pro Cys Glu Thr Leu
                 350                 355                 360

 ggc ctg tct cac ctt tca gga atg tgt cag cct cac cgc agt tgt aac     1457
 Gly Leu Ser His Leu Ser Gly Met Cys Gln Pro His Arg Ser Cys Asn
             365                 370                 375

 atc aat gaa gat tcg gga ctc cct ctg gct ttc aca att gcc cat gag     1505
 Ile Asn Glu Asp Ser Gly Leu Pro Leu Ala Phe Thr Ile Ala His Glu
         380                 385                 390

 cta gga cac agc ttc ggc atc cag cat gat ggg aaa gaa aat gac tgt     1553
 Leu Gly His Ser Phe Gly Ile Gln His Asp Gly Lys Glu Asn Asp Cys
     395                 400                 405

 gag cct gtg ggc aga cat ccg tac atc atg tcc cgc cag ctc cag tac     1601
 Glu Pro Val Gly Arg His Pro Tyr Ile Met Ser Arg Gln Leu Gln Tyr
 410                 415                 420                 425

 gat ccc act ccg ctg aca tgg tcc aag tgc agc gag gag tac atc acc     1649
 Asp Pro Thr Pro Leu Thr Trp Ser Lys Cys Ser Glu Glu Tyr Ile Thr
                 430                 435                 440

 cgc ttc ttg gac cga ggc tgg ggg ttc tgt ctt gat gac ata cct aaa     1697
 Arg Phe Leu Asp Arg Gly Trp Gly Phe Cys Leu Asp Asp Ile Pro Lys
             445                 450                 455

 aag aaa ggc ttg aag tcc aag gtc att gcc ccc gga gtg atc tat gat     1745
 Lys Lys Gly Leu Lys Ser Lys Val Ile Ala Pro Gly Val Ile Tyr Asp
         460                 465                 470

 gtt cac cac cag tgc cag cta caa tat gga ccc aat gct acc ttc tgc     1793
 Val His His Gln Cys Gln Leu Gln Tyr Gly Pro Asn Ala Thr Phe Cys
     475                 480                 485

 cag gaa gta gaa aac gtc tgc cag aca ctg tgg tgc tcc gtg aag ggc     1841
 Gln Glu Val Glu Asn Val Cys Gln Thr Leu Trp Cys Ser Val Lys Gly
 490                 495                 500                 505

 ttt tgt cgc tct aag ctg gac gct gct gca gat gga act caa tgt ggt     1889
 Phe Cys Arg Ser Lys Leu Asp Ala Ala Ala Asp Gly Thr Gln Cys Gly
                 510                 515                 520

 gag aag aag tgg tgt atg gca ggc aag tgc atc aca gtg ggg aag aaa     1937
 Glu Lys Lys Trp Cys Met Ala Gly Lys Cys Ile Thr Val Gly Lys Lys
             525                 530                 535

 cca gag agc att cct gga ggc tgg ggc cgc tgg tca ccc tgg tcc cac     1985
 Pro Glu Ser Ile Pro Gly Gly Trp Gly Arg Trp Ser Pro Trp Ser His
         540                 545                 550

 tgt tcc agg acc tgt ggg gct gga gtc cag agc gca gag agg ctc tgc     2033
 Cys Ser Arg Thr Cys Gly Ala Gly Val Gln Ser Ala Glu Arg Leu Cys
     555                 560                 565

 aac aac ccc gag cca aag ttt gga ggg aaa tat tgc act gga gaa aga     2081
 Asn Asn Pro Glu Pro Lys Phe Gly Gly Lys Tyr Cys Thr Gly Glu Arg
 570                 575                 580                 585

 aaa cgc tat cgc ttg tgc aac gtc cac ccc tgt cgc tca gag gca cca     2129
 Lys Arg Tyr Arg Leu Cys Asn Val His Pro Cys Arg Ser Glu Ala Pro
                 590                 595                 600

 aca ttt cgg cag atg cag tgc agt gaa ttt gac act gtt ccc tac aag     2177
 Thr Phe Arg Gln Met Gln Cys Ser Glu Phe Asp Thr Val Pro Tyr Lys
             605                 610                 615

 aat gaa ctc tac cac tgg ttt ccc att ttt aac cca gca cat cct tgt     2225
 Asn Glu Leu Tyr His Trp Phe Pro Ile Phe Asn Pro Ala His Pro Cys
         620                 625                 630

 gag ctc tac tgc cga ccc ata gat ggc cag ttt tct gag aaa atg ctg     2273
 Glu Leu Tyr Cys Arg Pro Ile Asp Gly Gln Phe Ser Glu Lys Met Leu
     635                 640                 645

 gat gct gtc att gat ggt acc cct tgc ttt gaa ggc ggc aac agc aga     2321
 Asp Ala Val Ile Asp Gly Thr Pro Cys Phe Glu Gly Gly Asn Ser Arg
 650                 655                 660                 665

 aat gtc tgt att aat ggc ata tgt aag atg gtt ggc tgt gac tat gag     2369
 Asn Val Cys Ile Asn Gly Ile Cys Lys Met Val Gly Cys Asp Tyr Glu
                 670                 675                 680

 atc gat tcc aat gcc acc gag gat cgc tgc ggt gtg tgc ctg gga gat     2417
 Ile Asp Ser Asn Ala Thr Glu Asp Arg Cys Gly Val Cys Leu Gly Asp
             685                 690                 695

 ggc tct tcc tgc cag act gtg aga aag atg ttt aag cag aag gaa gga     2465
 Gly Ser Ser Cys Gln Thr Val Arg Lys Met Phe Lys Gln Lys Glu Gly
         700                 705                 710

 tct ggt tat gtt gac att ggg ctc att cca aaa gga gca agg gac ata     2513
 Ser Gly Tyr Val Asp Ile Gly Leu Ile Pro Lys Gly Ala Arg Asp Ile
     715                 720                 725

 aga gtg atg gaa att gag gga gct gga aac ttc ctg gcc atc agg agt     2561
 Arg Val Met Glu Ile Glu Gly Ala Gly Asn Phe Leu Ala Ile Arg Ser
 730                 735                 740                 745

 gaa gat cct gaa aaa tat tac ctg aat gga ggg ttt att atc cag tgg     2609
 Glu Asp Pro Glu Lys Tyr Tyr Leu Asn Gly Gly Phe Ile Ile Gln Trp
                 750                 755                 760

 aac ggg aac tat aag ctg gca ggg act gtc ttt cag tat gac agg aaa     2657
 Asn Gly Asn Tyr Lys Leu Ala Gly Thr Val Phe Gln Tyr Asp Arg Lys
             765                 770                 775

 gga gac ctg gaa aag ctg atg gcc aca ggt ccc acc aat gag tct gtg     2705
 Gly Asp Leu Glu Lys Leu Met Ala Thr Gly Pro Thr Asn Glu Ser Val
         780                 785                 790

 tgg atc cag ctt cta ttc cag gtg act aac cct ggc atc aag tat gag     2753
 Trp Ile Gln Leu Leu Phe Gln Val Thr Asn Pro Gly Ile Lys Tyr Glu
     795                 800                 805

 tac aca atc cag aaa gat ggc ctt gac aat gat gtt gag cag atg tac     2801
 Tyr Thr Ile Gln Lys Asp Gly Leu Asp Asn Asp Val Glu Gln Met Tyr
 810                 815                 820                 825

 ttc tgg cag tac ggc cac tgg aca gag tgc agt gtg acc tgc ggg aca     2849
 Phe Trp Gln Tyr Gly His Trp Thr Glu Cys Ser Val Thr Cys Gly Thr
                 830                 835                 840

 ggt atc cgc cgc caa act gcc cat tgc ata aag aag ggc cgc ggg atg     2897
 Gly Ile Arg Arg Gln Thr Ala His Cys Ile Lys Lys Gly Arg Gly Met
             845                 850                 855

 gtg aaa gct aca ttc tgt gac cca gaa aca cag ccc aat ggg aga cag     2945
 Val Lys Ala Thr Phe Cys Asp Pro Glu Thr Gln Pro Asn Gly Arg Gln
         860                 865                 870

 aag aag tgc cat gaa aag gct tgt cca ccc agg tgg tgg gca ggg gag     2993
 Lys Lys Cys His Glu Lys Ala Cys Pro Pro Arg Trp Trp Ala Gly Glu
     875                 880                 885

 tgg gaa gca tgc tcg gcg aca tgc ggg ccc cac ggg gag aag aag cga     3041
 Trp Glu Ala Cys Ser Ala Thr Cys Gly Pro His Gly Glu Lys Lys Arg
 890                 895                 900                 905

 acc gtg ctg tgc atc cag acc atg gtc tct gac gag cag gct ctc ccg     3089
 Thr Val Leu Cys Ile Gln Thr Met Val Ser Asp Glu Gln Ala Leu Pro
                 910                 915                 920

 ccc aca gac tgc cag cac ctg ctg aag ccc aag acc ctc ctt tcc tgc     3137
 Pro Thr Asp Cys Gln His Leu Leu Lys Pro Lys Thr Leu Leu Ser Cys
             925                 930                 935

 aac aga gac atc ctg tgc ccc tcg gac tgg aca gtg ggc aac tgg agt     3185
 Asn Arg Asp Ile Leu Cys Pro Ser Asp Trp Thr Val Gly Asn Trp Ser
         940                 945                 950

 gag tgt tct gtt tcc tgt ggt ggt gga gtg cgg att cgc agt gtc aca     3233
 Glu Cys Ser Val Ser Cys Gly Gly Gly Val Arg Ile Arg Ser Val Thr
     955                 960                 965

 tgt gcc aag aac cat gat gaa cct tgc gat gtg aca agg aaa ccc aac     3281
 Cys Ala Lys Asn His Asp Glu Pro Cys Asp Val Thr Arg Lys Pro Asn
 970                 975                 980                 985

 agc cga gct ctg tgt ggc ctc cag caa tgc cct tct agc cgg aga gtt     3329
 Ser Arg Ala Leu Cys Gly Leu Gln Gln Cys Pro Ser Ser Arg Arg Val
                 990                 995                1000

 ctg aaa cca aac aaa ggc act att tcc aat gga aaa aac cca cca aca     3377
 Leu Lys Pro Asn Lys Gly Thr Ile Ser Asn Gly Lys Asn Pro Pro Thr
            1005                1010                1015

 cta aag ccc gtc cct cca cct aca tcc agg ccc aga atg ctg acc aca     3425
 Leu Lys Pro Val Pro Pro Pro Thr Ser Arg Pro Arg Met Leu Thr Thr
        1020                1025                1030

 ccc aca ggg cct gag tct atg agc aca agc act cca gca atc agc agc     3473
 Pro Thr Gly Pro Glu Ser Met Ser Thr Ser Thr Pro Ala Ile Ser Ser
    1035                1040                1045

 cct agt cct acc aca gcc tcc aaa gaa gga gac ctg ggt ggg aaa cag     3521
 Pro Ser Pro Thr Thr Ala Ser Lys Glu Gly Asp Leu Gly Gly Lys Gln
1050                1055                1060                1065

 tgg caa gat agc tca acc caa cct gag ctg agc tct cgc tat ctc att     3569
 Trp Gln Asp Ser Ser Thr Gln Pro Glu Leu Ser Ser Arg Tyr Leu Ile
                1070                1075                1080

 tcc act gga agc act tcc cag ccc atc ctc act tcc caa tcc ttg agc     3617
 Ser Thr Gly Ser Thr Ser Gln Pro Ile Leu Thr Ser Gln Ser Leu Ser
            1085                1090                1095

 att cag cca agt gag gaa aat gtt tcc agt tca gat act ggt cct acc     3665
 Ile Gln Pro Ser Glu Glu Asn Val Ser Ser Ser Asp Thr Gly Pro Thr
        1100                1105                1110

 tcg gag gga ggc ctt gta gct aca aca aca agt ggt tct ggc ttg tca     3713
 Ser Glu Gly Gly Leu Val Ala Thr Thr Thr Ser Gly Ser Gly Leu Ser
    1115                1120                1125

 tct tcc cgc aac cct atc act tgg cct gtg act cca ttt tac aat acc     3761
 Ser Ser Arg Asn Pro Ile Thr Trp Pro Val Thr Pro Phe Tyr Asn Thr
1130                1135                1140                1145

 ttg acc aaa ggt cca gaa atg gag att cac agt ggc tca ggg gaa gaa     3809
 Leu Thr Lys Gly Pro Glu Met Glu Ile His Ser Gly Ser Gly Glu Glu
                1150                1155                1160

 aga gaa cag cct gag gac aaa gat gaa agc aat cct gta ata tgg acc     3857
 Arg Glu Gln Pro Glu Asp Lys Asp Glu Ser Asn Pro Val Ile Trp Thr
            1165                1170                1175

 aag atc aga gta cct gga aat gac gct cca gtg gaa agt aca gaa atg     3905
 Lys Ile Arg Val Pro Gly Asn Asp Ala Pro Val Glu Ser Thr Glu Met
        1180                1185                1190

 cca ctt gca cct cca cta aca cca gat ctc agc agg gag tcc tgg tgg     3953
 Pro Leu Ala Pro Pro Leu Thr Pro Asp Leu Ser Arg Glu Ser Trp Trp
    1195                1200                1205

 cca ccc ttc agc aca gta atg gaa gga ctg ctc ccc agc caa agg ccc     4001
 Pro Pro Phe Ser Thr Val Met Glu Gly Leu Leu Pro Ser Gln Arg Pro
1210                1215                1220                1225

 act act tcc gaa act ggg aca ccc aga gtt gag ggg atg gtt act gaa     4049
 Thr Thr Ser Glu Thr Gly Thr Pro Arg Val Glu Gly Met Val Thr Glu
                1230                1235                1240

 aag cca gcc aac act ctg ctc cct ctg gga gga gac cac cag cca gaa     4097
 Lys Pro Ala Asn Thr Leu Leu Pro Leu Gly Gly Asp His Gln Pro Glu
            1245                1250                1255

 ccc tca gga aag acg gca aac cgt aac cac ctg aaa ctt cca aac aac     4145
 Pro Ser Gly Lys Thr Ala Asn Arg Asn His Leu Lys Leu Pro Asn Asn
        1260                1265                1270

 atg aac caa aca aaa agt tct gaa cca gtc ctg act gag gag gat gca     4193
 Met Asn Gln Thr Lys Ser Ser Glu Pro Val Leu Thr Glu Glu Asp Ala
    1275                1280                1285

 aca agt ctg att act gag ggc ttt ttg cta aat gcc tcc aat tac aag     4241
 Thr Ser Leu Ile Thr Glu Gly Phe Leu Leu Asn Ala Ser Asn Tyr Lys
1290                1295                1300                1305

 cag ctc aca aac ggc cac ggc tct gca cac tgg atc gtc gga aac tgg     4289
 Gln Leu Thr Asn Gly His Gly Ser Ala His Trp Ile Val Gly Asn Trp
                1310                1315                1320

 agc gag tgc tcc acc aca tgt ggc ctg ggg gcc tac tgg aaa agg gtg     4337
 Ser Glu Cys Ser Thr Thr Cys Gly Leu Gly Ala Tyr Trp Lys Arg Val
            1325                1330                1335

 gag tgc acc acc cag atg gat tct gac tgt gcg gcc atc cag aga cct     4385
 Glu Cys Thr Thr Gln Met Asp Ser Asp Cys Ala Ala Ile Gln Arg Pro
        1340                1345                1350

 gac cct gca aaa aga tgc cac ctc cgt ccc tgt gct ggc tgg aaa gtg     4433
 Asp Pro Ala Lys Arg Cys His Leu Arg Pro Cys Ala Gly Trp Lys Val
    1355                1360                1365

 gga aac tgg agc aag tgc tcc aga aac tgc agt ggg ggc ttc aag ata     4481
 Gly Asn Trp Ser Lys Cys Ser Arg Asn Cys Ser Gly Gly Phe Lys Ile
1370                1375                1380                1385

 cgc gag att cag tgc gtg gac agc cgg gac cac cgg aac ctg agg cca     4529
 Arg Glu Ile Gln Cys Val Asp Ser Arg Asp His Arg Asn Leu Arg Pro
                1390                1395                1400

 ttt cac tgc cag ttc ctg gcc ggc att cct ccc cca ttg agc atg agc     4577
 Phe His Cys Gln Phe Leu Ala Gly Ile Pro Pro Pro Leu Ser Met Ser
            1405                1410                1415

 tgt aac ccg gag ccc tgt gag gcg tgg cag gtg gag cct tgg agc cag     4625
 Cys Asn Pro Glu Pro Cys Glu Ala Trp Gln Val Glu Pro Trp Ser Gln
        1420                1425                1430

 tgc tcc agg tcc tgt gga ggt gga gtt cag gag aga gga gtg ttc tgt     4673
 Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Glu Arg Gly Val Phe Cys
    1435                1440                1445

 cca gga ggc ctc tgt gat tgg aca aaa aga ccc aca tcc acc atg tct     4721
 Pro Gly Gly Leu Cys Asp Trp Thr Lys Arg Pro Thr Ser Thr Met Ser
1450                1455                1460                1465

 tgc aat gag cac ctg tgc tgt cac tgg gcc act ggg aac tgg gac ctg     4769
 Cys Asn Glu His Leu Cys Cys His Trp Ala Thr Gly Asn Trp Asp Leu
                1470                1475                1480

 tgt tcc act tcc tgt gga ggt ggc ttt cag aag agg att gtc caa tgt     4817
 Cys Ser Thr Ser Cys Gly Gly Gly Phe Gln Lys Arg Ile Val Gln Cys
            1485                1490                1495

 gtg ccc tca gag ggc aat aaa act gaa gac caa gac caa tgt cta tgt     4865
 Val Pro Ser Glu Gly Asn Lys Thr Glu Asp Gln Asp Gln Cys Leu Cys
        1500                1505                1510

 gat cac aaa ccc aga cct cca gaa ttc aaa aaa tgc aac cag cag gcc     4913
 Asp His Lys Pro Arg Pro Pro Glu Phe Lys Lys Cys Asn Gln Gln Ala
    1515                1520                1525

 tgc aag aaa agt gcc gat tta ctt tgc act aag gac aaa ctg tca gcc     4961
 Cys Lys Lys Ser Ala Asp Leu Leu Cys Thr Lys Asp Lys Leu Ser Ala
1530                1535                1540                1545

 agt ttc tgc cag aca ctg aaa gcc atg aag aaa tgt tct gtg ccc acc     5009
 Ser Phe Cys Gln Thr Leu Lys Ala Met Lys Lys Cys Ser Val Pro Thr
                1550                1555                1560

 gtg agg gct gag tgc tgc ttc tcg tgt ccc cag aca cac atc aca cac     5057
 Val Arg Ala Glu Cys Cys Phe Ser Cys Pro Gln Thr His Ile Thr His
            1565                1570                1575

 acc caa agg caa aga agg caa cgg ttg ctc caa aag tca aaa gaa ctc     5105
 Thr Gln Arg Gln Arg Arg Gln Arg Leu Leu Gln Lys Ser Lys Glu Leu
        1580                1585                1590

 taa gcccaaa                                                         5115
 






      <210> 172
      <211> 213
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (10)..(162)

      <400> 172
 cccttcacc    atg gga aag gag agt gga tgg gac tca ggc agg gct gct      48
              Met Gly Lys Glu Ser Gly Trp Asp Ser Gly Arg Ala Ala
                1               5                  10

 gta gca gct gtg gtc gga gga ggg gca gct gga ctc tct gtg aca tct       96
 Val Ala Ala Val Val Gly Gly Gly Ala Ala Gly Leu Ser Val Thr Ser
      15                  20                  25

 aaa gtt atc ggg ggc ttt gct ggg aca gct ctt ggg gcc tgg ctg ggt      144
 Lys Val Ile Gly Gly Phe Ala Gly Thr Ala Leu Gly Ala Trp Leu Gly
  30                  35                  40                  45

 tca ccc cct tcc agc tga acacca cacctaggtg atcaattaat ccagcaaggg      198
 Ser Pro Pro Ser Ser 
                  50

 caattctgca gatat                                                     213




      <210> 173
      <211> 2539
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (281)..(1270)

      <400> 173
 ccgccggctt tgtgtgccgc gcgcgcggcc cgggccgccc gcgcctcgcc tgggttccgg     60

 ggccgccgct gacccgcccg ggctccgagc gccgcgcccg ccgggccggc cccgcctcct    120

 gccctcctcc gcctccgcct cctcctgccg ccgggcgggc gggctgcagc cgccctccgc    180

 gctcgcctgc cagctccctc gccgcgcgtc cgtcctccgt cctcccgggc cagccagcca    240

 gccagccagc cgggccggcg gcgggcacca ggccgtcccg  atg ccc gag cca ggc     295
                                              Met Pro Glu Pro Gly
                                                1               5

 ccc agg atg aac ggc ttc tcg ctg ggc gag ctg tgc tgg ctc ttc tgc      343
 Pro Arg Met Asn Gly Phe Ser Leu Gly Glu Leu Cys Trp Leu Phe Cys
                  10                  15                  20

 tgc ccg ccc tgc ccg agc cgc atc gcc gcc aag ctg gcc ttc ctg ccg      391
 Cys Pro Pro Cys Pro Ser Arg Ile Ala Ala Lys Leu Ala Phe Leu Pro
              25                  30                  35

 ccc gag ccc acc tac acg gtg ctg gcg ccg gag cag cgc gcc gcc ggc      439
 Pro Glu Pro Thr Tyr Thr Val Leu Ala Pro Glu Gln Arg Ala Ala Gly
          40                  45                  50

 gcg tcc gcc ccg gcc ccg gcc cag gct acc gcc gcc gcc gcc gcg gcc      487
 Ala Ser Ala Pro Ala Pro Ala Gln Ala Thr Ala Ala Ala Ala Ala Ala
      55                  60                  65

 cag ccg gca ccg cag cag ccc gag gag ggc gcg ggc gcg ggg ccc ggt      535
 Gln Pro Ala Pro Gln Gln Pro Glu Glu Gly Ala Gly Ala Gly Pro Gly
  70                  75                  80                  85

 gcg tgc agc ctg cac ctc agc gag cgc gcc gac tgg cag tac tcg cag      583
 Ala Cys Ser Leu His Leu Ser Glu Arg Ala Asp Trp Gln Tyr Ser Gln
                  90                  95                 100

 cgc gag ctg gac gcc gtc gag gtc ttc ttc tcg cgc acg gcc cgg gac      631
 Arg Glu Leu Asp Ala Val Glu Val Phe Phe Ser Arg Thr Ala Arg Asp
             105                 110                 115

 aac cgg ctc ggc tgc atg ttc gtg cgc tgc gcg ccc tcc agc cgc tac      679
 Asn Arg Leu Gly Cys Met Phe Val Arg Cys Ala Pro Ser Ser Arg Tyr
         120                 125                 130

 acg ctg ctc ttc tcg cac ggc aac gcc ggg gac ctg ggc cag atg tgc      727
 Thr Leu Leu Phe Ser His Gly Asn Ala Gly Asp Leu Gly Gln Met Cys
     135                 140                 145

 agc ttc tac att ggc ctc ggc tcc cgc atc aac tgc aac atc ttc tcc      775
 Ser Phe Tyr Ile Gly Leu Gly Ser Arg Ile Asn Cys Asn Ile Phe Ser
 150                 155                 160                 165

 tac gac tac tcg gga tac ggc gtc agc tcg ggc aag ccc tcc gag aag      823
 Tyr Asp Tyr Ser Gly Tyr Gly Val Ser Ser Gly Lys Pro Ser Glu Lys
                 170                 175                 180

 aac ctc tac gcc gac atc gac gcc gcg tgg cag gcg ctg cgc acc cgg      871
 Asn Leu Tyr Ala Asp Ile Asp Ala Ala Trp Gln Ala Leu Arg Thr Arg
             185                 190                 195

 tat ggc gtg agt ccc gag aac att atc ctc tat ggt cag agc att ggg      919
 Tyr Gly Val Ser Pro Glu Asn Ile Ile Leu Tyr Gly Gln Ser Ile Gly
         200                 205                 210

 act gtc ccc acg gta gac ttg gcc tcg agg tat gaa tgc gca gcg gta      967
 Thr Val Pro Thr Val Asp Leu Ala Ser Arg Tyr Glu Cys Ala Ala Val
     215                 220                 225

 att ctc cat tcc cct ctg atg tct ggt ttg cgt gtg gct ttt ccg gat     1015
 Ile Leu His Ser Pro Leu Met Ser Gly Leu Arg Val Ala Phe Pro Asp
 230                 235                 240                 245

 acc agg aaa aca tac tgc ttt gat gct ttc ccc agc att gac aag ata     1063
 Thr Arg Lys Thr Tyr Cys Phe Asp Ala Phe Pro Ser Ile Asp Lys Ile
                 250                 255                 260

 tct aaa gtc acc tct cct gtg ttg gtc att cat ggt aca gag gat gag     1111
 Ser Lys Val Thr Ser Pro Val Leu Val Ile His Gly Thr Glu Asp Glu
             265                 270                 275

 gtc atc gat ttc tcc cat ggc cta gcg atg tac gag cgc tgt ccc cga     1159
 Val Ile Asp Phe Ser His Gly Leu Ala Met Tyr Glu Arg Cys Pro Arg
         280                 285                 290

 gcc gtg gag ccc ctt tgg gtt gaa ggg gct ggg cat aat gac ata gag     1207
 Ala Val Glu Pro Leu Trp Val Glu Gly Ala Gly His Asn Asp Ile Glu
     295                 300                 305

 ctt tat gca caa tac cta gaa aga cta aaa cag ttc ata tct cac gaa     1255
 Leu Tyr Ala Gln Tyr Leu Glu Arg Leu Lys Gln Phe Ile Ser His Glu
 310                 315                 320                 325

 ctt cct aat tcc tga agacaacaac ttgatcttac ctcatttact gtgaacagaa     1310
 Leu Pro Asn Ser 


 gagtcctctg ttttgcacat gctttaactg ggtagctgta aaggcttgat aaccatgaag   1370

 aagtgcccaa cctttagggt gttctaatca aagagctgat gaaatctcag tcttttgtat   1430

 ctagaggtgg ttctgctaat tcacacaaca cgttaaactg aacagtcgtg attcccagct   1490

 tcattacctt gcaggaatgg gaatgagagc tgaatgtagg gacaattttc tagtgctgta   1550

 taaagtagcc tcgcatctgt ttctcaacct tatccatcat ttctgacatt catgcaggac   1610

 ttgccctgtt gccaccaatg ttctcggtat ttcacatgca gctctctttc tgccactgga   1670

 tacatgggtt caatccattt gtgaagctgt gatagtgtaa ctggaaagct agtgtggtga   1730

 aaattccttt attatttttt gttaacatgc tgatctttcc cggacaaatg aactgaaggg   1790

 taatttactg gaactctcgt gtacagcttc atcaactgta accatataaa tataactgga   1850

 atattcttaa acaaaaagaa actaggggtt tttttaagtg taaatttatt actagccaac   1910

 agagttttac tattttgatt gtctggttgg tttaacaaag agcctagctg actttccttc   1970

 tgtaaagtcc tccttgtagg cttttttaaa gtactgtaca tatttgcaat cacattgtgc   2030

 atagattctt aatggtagat atgatttctt ttgtcaggct acaacaatga actgcagatt   2090

 ccttgtttgt aatgtaaatg attgaataca ttttgttaat atgtttttat tcctatgttt   2150

 tgctattaaa aattttataa catttccaag acaaaaattc caagtttatg ctttgaagaa   2210

 tttatgtaat taaaatttca ctaaactaat ctttttagtt taggaattat ttgggttttg   2270

 acactggaag ttgcgccaaa taagcatcag aaataggaga tgcttaacat tgctatacta   2330

 cttgtgttgg ttaggggttt ggatttgggg gttctttggt tttaattttt ttttccacat   2390

 ttaaaagcct taaatgtact gtaagcctca gatcgttgta caactggact gcggttgatt   2450

 gccagtttgt gtactgttgc ttggatgcgg cacagtggtt ggtaatggaa taaaggatgc   2510

 atggatcaga aaaaaaaaaa aaaaaaaaa                                     2539




      <210> 174
      <211> 2238
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(969)

      <400> 174
  atg aac ggc ttc tcg ctg ggt gag ctg tgc tgg ctc ttc tgc tgc ccg      48
  Met Asn Gly Phe Ser Leu Gly Glu Leu Cys Trp Leu Phe Cys Cys Pro
    1               5                  10                  15

 ccc tgc ccg agc cgc atc gcc gcc aag ctg gcc ttc ctg ccg ccc gag       96
 Pro Cys Pro Ser Arg Ile Ala Ala Lys Leu Ala Phe Leu Pro Pro Glu
              20                  25                  30

 ccc acc tac acg gtg ctg gcg ccg gag cag cgc ggc gcc ggc gcg tcc      144
 Pro Thr Tyr Thr Val Leu Ala Pro Glu Gln Arg Gly Ala Gly Ala Ser
          35                  40                  45

 gcc ccg gcc ccg gcc cag gct acc gcc gcc gcc gcc gcg gcc cag ccg      192
 Ala Pro Ala Pro Ala Gln Ala Thr Ala Ala Ala Ala Ala Ala Gln Pro
      50                  55                  60

 gca ccg cag cag ccc gag gag ggc gcg ggc gcg ggg ccc ggt gcg tgc      240
 Ala Pro Gln Gln Pro Glu Glu Gly Ala Gly Ala Gly Pro Gly Ala Cys
  65                  70                  75                  80

 agc ctg cac ctc agc gag cgc gcc gac tgg cag tac tcg cag cgc gag      288
 Ser Leu His Leu Ser Glu Arg Ala Asp Trp Gln Tyr Ser Gln Arg Glu
                  85                  90                  95

 ctg gac gcc gtc gag gtc ttc ttc tcg cgc acg gcc cgg gac aac cgg      336
 Leu Asp Ala Val Glu Val Phe Phe Ser Arg Thr Ala Arg Asp Asn Arg
             100                 105                 110

 ctc ggc tgc atg ttc gtg cgc tgc gcg ccc tcc agc cgc tac acg ctg      384
 Leu Gly Cys Met Phe Val Arg Cys Ala Pro Ser Ser Arg Tyr Thr Leu
         115                 120                 125

 ctc ttc tcg cac ggc aac gcc ggg gac ctg ggc cag atg tgc agc ttc      432
 Leu Phe Ser His Gly Asn Ala Gly Asp Leu Gly Gln Met Cys Ser Phe
     130                 135                 140

 tac att ggc ctc ggc tcc cgc atc aac tgc aac atc ttc tcc tac gac      480
 Tyr Ile Gly Leu Gly Ser Arg Ile Asn Cys Asn Ile Phe Ser Tyr Asp
 145                 150                 155                 160

 tac tcg gga tac ggc gtc agc tcg ggc aag ccc tcc gag aag aac ctc      528
 Tyr Ser Gly Tyr Gly Val Ser Ser Gly Lys Pro Ser Glu Lys Asn Leu
                 165                 170                 175

 tac gcc gac atc gac gcc gcg tgg cag gcg ctg cgc acc cgg tat ggc      576
 Tyr Ala Asp Ile Asp Ala Ala Trp Gln Ala Leu Arg Thr Arg Tyr Gly
             180                 185                 190

 gtg agt ccc gag aac att atc ctc tat ggt cag agc att ggg act gtc      624
 Val Ser Pro Glu Asn Ile Ile Leu Tyr Gly Gln Ser Ile Gly Thr Val
         195                 200                 205

 ccc acg gta gac ttg gcc tcg agg tat gaa tgc gca gcg gta att ctc      672
 Pro Thr Val Asp Leu Ala Ser Arg Tyr Glu Cys Ala Ala Val Ile Leu
     210                 215                 220

 cat tcc cct ctg atg tct ggt ttg cgt gtg gct ttt ccg gat acc agg      720
 His Ser Pro Leu Met Ser Gly Leu Arg Val Ala Phe Pro Asp Thr Arg
 225                 230                 235                 240

 aaa aca tac tgc ttt gat gct ttc ccc agc att gac aag ata tct aaa      768
 Lys Thr Tyr Cys Phe Asp Ala Phe Pro Ser Ile Asp Lys Ile Ser Lys
                 245                 250                 255

 gtc acc tct cct gtg ttg gtc att cat ggt aca gag gat gag gtc atc      816
 Val Thr Ser Pro Val Leu Val Ile His Gly Thr Glu Asp Glu Val Ile
             260                 265                 270

 gat ttc tcc cat ggc cta gcg atg tac gag cgc tgt ccc cga gcc gtg      864
 Asp Phe Ser His Gly Leu Ala Met Tyr Glu Arg Cys Pro Arg Ala Val
         275                 280                 285

 gag ccc ctt tgg gtt gaa ggg gct ggg cat aat gac ata gag ctt tat      912
 Glu Pro Leu Trp Val Glu Gly Ala Gly His Asn Asp Ile Glu Leu Tyr
     290                 295                 300

 gca caa tac cta gaa aga cta aaa cag ttc ata tct cac gaa ctt cct      960
 Ala Gln Tyr Leu Glu Arg Leu Lys Gln Phe Ile Ser His Glu Leu Pro
 305                 310                 315                 320

 aat tcc tga agacaac aacttgatct tacctcattt actgtgaaca gaagagtcct     1016
 Asn Ser 


 ctgttttgca catgctttaa ctgggtagct gtaaaggctt gataaccatg aagaagtgcc   1076

 caacctttag ggtgttctaa tcaaagagct gatgaaatct cagtcttttg tatctagagg   1136

 tggttctgct aattcacaca acacgttaaa ctgaacagtc gtgattccca gcttcattac   1196

 cttgcaggaa tgggaatgag agctgaatgt agggacaatt ttctagtgct gtataaagta   1256

 gcctcgcatc tgtttctcaa ccttatccat catttctgac attcatgcag gacttgccct   1316

 gttgccacca atgttctcgg tatttcacat gcagctctct ttctgccact ggatacatgg   1376

 gttcaatcca tttgtgaagc tgtgatagtg taactggaaa gctagtgtgg tgaaaattcc   1436

 tttattattt tttgttaaca tgctgatctt tcccggacaa atgaactgaa gggtaattta   1496

 ctggaactct cgtgtacagc ttcatcaact gtaaccatat aaatataact ggaatattct   1556

 taaacaaaaa gaaactaggg gtttttttaa gtgtaaattt attactagcc aacagagttt   1616

 tactattttg attgtctggt tggtttaaca aagagcctag ctgactttcc ttctgtaaag   1676

 tcctccttgt aggctttttt aaagtactgt acatatttgc aatcacattg tgcatagatt   1736

 cttaatggta gatatgattt cttttgtcag gctacaacaa tgaactgcag attccttgtt   1796

 tgtaatgtaa atgattgaat acattttgtt aatatgtttt tattcctatg ttttgctatt   1856

 aaaaatttta taacatttcc aagacaaaaa ttccaagttt atgctttgaa gaatttatgt   1916

 aattaaaatt tcactaaact aatcttttta gtttaggaat tatttgggtt ttgacactgg   1976

 aagttgcgcc aaataagcat cagaaatagg agatgcttaa cattgctata ctacttgtgt   2036

 tggttagggg tttggatttg ggggttcttt ggttttaatt tttttttcca catttaaaag   2096

 ccttaaatgt actgtaagcc tcagatcgtt gtacaactgg actgcggttg attgccagtt   2156

 tgtgtactgt tgcttggatg cggcacagtg gttggtaatg gaataaagga tgcatggatc   2216

 agaaaaaaaa aaaaaaaaaa aa                                            2238




      <210> 175
      <211> 2991
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1308)

      <400> 175
  atg act ttg gtg att aag ttt cca cat tcg aat ttt ggg ggg ctt att      48
  Met Thr Leu Val Ile Lys Phe Pro His Ser Asn Phe Gly Gly Leu Ile
    1               5                  10                  15

 cag att gca gca gtg tcc agg ccg cgc agc tcc cct gac gac ctg aag       96
 Gln Ile Ala Ala Val Ser Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys
              20                  25                  30

 gcc ctg act cgc aat gtg aac cgg ctg aat gag agc ttc cgg gac ttg      144
 Ala Leu Thr Arg Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu
          35                  40                  45

 cag ctg cgg ctg ctg cag gct ccg ctg caa gcg gac ctg acg gag cag      192
 Gln Leu Arg Leu Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln
      50                  55                  60

 gtg tgg aag gtg cag gac gcg ctg cag aac cag tca gac tcg ttg ctg      240
 Val Trp Lys Val Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu
  65                  70                  75                  80

 gcg ctg gcg ggc gca gtg cag cgg ctg gag ggc gcg ctg tgg ggg ctg      288
 Ala Leu Ala Gly Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu
                  85                  90                  95

 cag gcg cag gcg gtg cag acc gag cag gcg gtg gcc ctg ctg cgg gac      336
 Gln Ala Gln Ala Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg Asp
             100                 105                 110

 cgc acg ggc cag cag agc gac acg gcg cag ctg gag ctc tac cag ctg      384
 Arg Thr Gly Gln Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu
         115                 120                 125

 cag gtg gag agc aac agt agc cag ctg ctg ctg agg cgc cac gcg ggc      432
 Gln Val Glu Ser Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala Gly
     130                 135                 140

 ctg ctg gac ggg ctg gcg cgc agg gtg ggc atc ctg ggc gag gag ctg      480
 Leu Leu Asp Gly Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu Leu
 145                 150                 155                 160

 gcc gac gtg ggc ggc gtg ctg cgc ggc ctc aac cac agc ctg tcc tac      528
 Ala Asp Val Gly Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser Tyr
                 165                 170                 175

 gac gtg gcc ctc cac tgc acg cgg ctg cag gac ctg cgg gtg ctg gtg      576
 Asp Val Ala Leu His Cys Thr Arg Leu Gln Asp Leu Arg Val Leu Val
             180                 185                 190

 agc aac gcc agc gag gac acg cgc cgc ctg cgc ctg gcg cac gta ggc      624
 Ser Asn Ala Ser Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val Gly
         195                 200                 205

 atg gag ctg cag ctg aag cag gag ctg gcc atg ctc aac gcg gtc acc      672
 Met Glu Leu Gln Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val Thr
     210                 215                 220

 gag gac ctg cgc ctc aag gac tgg gag cac tcc atc gca ctg cgg aac      720
 Glu Asp Leu Arg Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg Asn
 225                 230                 235                 240

 atc tcc ctc gcg aaa ggg cca ccg gga ccc aaa ggt gat cag ggg cat      768
 Ile Ser Leu Ala Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly His
                 245                 250                 255

 gaa gga aag gaa ggc agg cct ggc atc cct gga ttg cct gga ctt cga      816
 Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg
             260                 265                 270

 ggt ctg ccc ggg gag aga ggt acc cca gga ttg ccc ggg ccc aag ggc      864
 Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly
         275                 280                 285

 gat gat ggg aag ctg ggg gcc aca gga cca atg ggc atg cgt ggg ttc      912
 Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe
     290                 295                 300

 aaa ggt gac cga ggc cca aaa gga gag aaa gga gag aaa gga gac aga      960
 Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg
 305                 310                 315                 320

 gct ggg gat gcc agt ggc gtg gag gcc ccg atg atg atc cgc ctg gtg     1008
 Ala Gly Asp Ala Ser Gly Val Glu Ala Pro Met Met Ile Arg Leu Val
                 325                 330                 335

 aat ggc tca ggt ccg cac gag ggc cgc gtg gaa gtg tac cac gac cgg     1056
 Asn Gly Ser Gly Pro His Glu Gly Arg Val Glu Val Tyr His Asp Arg
             340                 345                 350

 cgc tgg ggc acc gtg tgt gac gac ggc tgg gac aag aag gac gga gac     1104
 Arg Trp Gly Thr Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp
         355                 360                 365

 gtg gtg tgc cgc atg ctc gcg tcg cgg tcg tgg agg agg tgt acc gca     1152
 Val Val Cys Arg Met Leu Ala Ser Arg Ser Trp Arg Arg Cys Thr Ala
     370                 375                 380

 cag cgt cga tcc gga cca ggc act cac agg atc tgg atg gat gac gtt     1200
 Gln Arg Arg Ser Gly Pro Gly Thr His Arg Ile Trp Met Asp Asp Val
 385                 390                 395                 400

 ccc tgc aag gca cca gag gaa acc att ttc cgc tgc agc ttc tcc aaa     1248
 Pro Cys Lys Ala Pro Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys
                 405                 410                 415

 tgg ggg gtg aca aac tgt gga cat gcc gaa gat gcc agc gtg aca tgc     1296
 Trp Gly Val Thr Asn Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys
             420                 425                 430

 aac aga cac tga aag tgggcagagc ccaagttcgg ggtcctgcac agagcaccct     1351
 Asn Arg His 
         435

 tcctgcatcc ctggggtggg gcacagctcg gggccatcct gaccatgcct cgaccacacc   1411

 ccgtccagca ttctcagtcc tcacacctgc atcccaggac cgtgggggcc ggtcgtcatt   1471

 tccctcttga acatgtgctc cgaagtataa ctctgggacc tactgcccgt ctctctcttc   1531

 caccaggttc ctgcatgagg agccctgatc aactggatca ccactttgcc cagcctctga   1591

 acaccatgca ccaggcctca atatcccagt tccctttggc cttttagtta caggtgaatg   1651

 ctgagaatgt gtcagagaca agtgcagcag cagcgatggt tggtagtata gatcatttac   1711

 tcttcagaca attcccaaac ctccattagt ccaagagttt ctacatcttc ctccccagca   1771

 agaggcaacg tcaagtgatg aatttccccc ctttactctg cctctgctcc ccatttgcta   1831

 gtttgaggaa gtgacataga ggagaagcca gctgtagggg caagagggaa atgcaagtca   1891

 cctgcaggaa tccagctaga tttggagaag ggaatgaaac taacattgaa tgactaccat   1951

 ggcacgctaa atagtatctt gggtgccaaa ttcatgtatc cacttagctg cattggtcca   2011

 gggcatgtca gtctggatac agccttacct ccaggtagca cttaactggt ccattcacct   2071

 agactgcaag taagaagaca aaatgactga gaccgtgtgc ccacctgaac ttattgtctt   2131

 tacttggcct gagctaaaag cttgggtgca ggacctgtgt aactagaaag ttgcctactt   2191

 cagaacctcc agggcgtgag tgcaaggtca aacatgactg gcttccaggc cgaccatcaa   2251

 tgtaggagga gagctgatgt ggagggtgac atgggggctg cccatgttaa acctgagtcc   2311

 agtgctctgg cattgggcag tcacggttaa agccaagtca tgtgtgtctc agctgtttgg   2371

 aggtgatgat tttgcatctt ccaagcctct tcaggtgtga atctgtggtc aggaaaacac   2431

 aagtcctaat ggaaccctta ggggggaagg aaatgaagat tccctataac ctctgggggt   2491

 ggggagtagg aataaggggc cttgggcctc cataaatctg caatctgcac cctcctccta   2551

 gagacaggga gatcgtgttc tgctttttac atgaggagca gaactgggcc atacacgtgt   2611

 tcaagaacta ggggagctac ctggtagcaa gtgagtgcag acccacctca ccttggggga   2671

 atctcaaact cataggcctc agatacacga tcacctgtca tatcaggtga gcactggcct   2731

 gcttggggag agacctgggc ccctccaggt gtaggaacag caacactcct ggctgacaac   2791

 taagccaata tggccctagg tcattcttgc ttccaatatg cttgccactc cttaaatgtc   2851

 ctaatgatga gaaactctct ttctgaccaa ttgctatgtt tacataacac gcatgtactc   2911

 atgcatccct tgccagagcc catatatgta tgcatatata aacatagcac tttttactac   2971

 atagctcagc acattgcaag                                               2991




      <210> 176
      <211> 2885
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (417)..(1904)

      <220>
      <221> misc_feature
      <222> (1)...(2885)
      <223> n = a,t,c or g

      <400> 176
 agagcagctg cagttcgcat ctcaggcagt acctagagga gctgccggtg cctcctcaga     60

 acatctcctg atcgctaccc aggaccaggc accaaggaca gggagtccca ggcgcacacc    120

 ccccattctg ggtcccccag gcccagaccc ccactctgcc acaggttgca tcttgacctg    180

 gtcctcctgc agaagtggcc cctgtggtcc tgctctgaga ctcgtccctg ggcgcccctg    240

 cagccccttt ctatgactcc atctggattt ggctggctgt ggggacgcgg tccgaggggc    300

 ggcctggctc tcagcgtggt ggcagccagc tctctggcca ccatggcaaa tgctgagatc    360

 tgaggggaca aggctctaca gcctcagcca ggggcactca gctgttgcag ggtgtg        416                                                                 
 atg gag aac aaa gct atg tac cta cac acc gtc agc gac tgt gac acc      464
 Met Glu Asn Lys Ala Met Tyr Leu His Thr Val Ser Asp Cys Asp Thr
   1               5                  10                  15

 agc tcc atc tgt gag gat tcc ttt gat ggc agg agc ctg tcc aag ctg      512
 Ser Ser Ile Cys Glu Asp Ser Phe Asp Gly Arg Ser Leu Ser Lys Leu
              20                  25                  30

 aac ctg tgt gag gat ggt cca tgt cac aaa cgg cgg gca agc atc tgc      560
 Asn Leu Cys Glu Asp Gly Pro Cys His Lys Arg Arg Ala Ser Ile Cys
          35                  40                  45

 tgt acc cag ctg ggg tcc ctg tcg gcc ctg aag cat gct gtc ctg ggg      608
 Cys Thr Gln Leu Gly Ser Leu Ser Ala Leu Lys His Ala Val Leu Gly
      50                  55                  60

 ctc tac ctg ctg gtc ttc ctg att ctt gtg ggc atc ttc atc tta gca      656
 Leu Tyr Leu Leu Val Phe Leu Ile Leu Val Gly Ile Phe Ile Leu Ala
  65                  70                  75                  80

 gtg tcc agg ccg cgc agc tcc cct gac gac ctg aag gcc ctg act cgc      704
 Val Ser Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr Arg
                  85                  90                  95

 aat gtg aac cgg ctg aat gag agc ttc cgg gac ttg cag ctg cgg ctg      752
 Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu Arg Leu
             100                 105                 110

 ctg cag gct ccg ctg caa gcg gac ctg acg gag cag gtg tgg aag gtg      800
 Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys Val
         115                 120                 125

 cag gac gcg ctg cag aac cag tca gac tcg ttg ctg gcg ctg gcg ggc      848
 Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu Ala Gly
     130                 135                 140

 gca gtg cag cgg ctg gag ggc gcg cta tgg ggg ctg cag gcg cag gcg      896
 Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Gln Ala Gln Ala
 145                 150                 155                 160

 gtg cag acc gag cag gcg gtg gcc ctg ctg cgg gac cgc acg ggc cag      944
 Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg Asp Arg Thr Gly Gln
                 165                 170                 175

 cag agc gac acg gcg cag ctg gag ctc tac cag ctg cag gtg gag agc      992
 Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu Ser
             180                 185                 190

 aac agt agc cag ctg ctg ctg agg cgc cac gcg ggc ctg ctg gac ggg     1040
 Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala Gly Leu Leu Asp Gly
         195                 200                 205

 ctg gcg cgc agg gtg ggc atc ctg ggc gag gag ctg gcc gac gtg ggc     1088
 Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu Leu Ala Asp Val Gly
     210                 215                 220

 ggc gtg ctg cgc ggc ctc aac cac agc ctg tcc tac gac gtg gcc ctc     1136
 Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala Leu
 225                 230                 235                 240

 cac tgc acg cgg ctg cag gac ctg cgg gtg ctg gtg agc aac gcc agc     1184
 His Cys Thr Arg Leu Gln Asp Leu Arg Val Leu Val Ser Asn Ala Ser
                 245                 250                 255

 gag gac acg cgc cgc ctg cgc ctg gcg cac gta ggc atg gag ctg cag     1232
 Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val Gly Met Glu Leu Gln
             260                 265                 270

 ctg aag cag gag ctg gcc atg ctc aac gcg gtc acc gag gac ctg cgc     1280
 Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val Thr Glu Asp Leu Arg
         275                 280                 285

 ctc aag gac tgg gag cac tcc atc gca ctg cgg aac atc tcc ctc gcg     1328
 Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Ser Leu Ala
     290                 295                 300

 aaa ggg cca ccg gga ccc aaa ggt gat cag ggg gat gaa gga aag gaa     1376
 Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu
 305                 310                 315                 320

 ggc agg cct ggc atc cct gga ttg cct gga ctt cga ggt ctg ccc ggg     1424
 Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly
                 325                 330                 335

 gag aga ggt acc cca gga ttg ccc ggg ccc aag ggc gat gat ggg aag     1472
 Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys
             340                 345                 350

 ctg ggg gcc aca gga cca atg ggc atg cgt ggg ttc aaa ggt gac cga     1520
 Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg
         355                 360                 365

 ggc cca aaa gga gag aaa gga gag aaa gga gac aga gct ggg gat gcc     1568
 Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala
     370                 375                 380

 agt ggc gtg gag gcc ccg atg atg atc cgc ctg gtg aat ggc tca ggt     1616
 Ser Gly Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly
 385                 390                 395                 400

 ccg cac gag ggc cgc gtg gaa gtg tac cac gac cgg cgt tgg ggc acc     1664
 Pro His Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr
                 405                 410                 415

 gtg tgt gac gac ggc tgg gac aag aag gac gga gac gtg gtg tgc cgc     1712
 Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg
             420                 425                 430

 atg ctc ggc ttc cgc ggt gtg gag gag gtg tac cgc aca gct cga ttc     1760
 Met Leu Gly Phe Arg Gly Val Glu Glu Val Tyr Arg Thr Ala Arg Phe
         435                 440                 445

 ggg caa ggc act ggg agg atc tgg atg gat gac gtt gcc tgc aag ggc     1808
 Gly Gln Gly Thr Gly Arg Ile Trp Met Asp Asp Val Ala Cys Lys Gly
     450                 455                 460

 aca gag gaa acc att ttc cgc tgc agc ttc tcc aaa tgg ggg gtg aca     1856
 Thr Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys Trp Gly Val Thr
 465                 470                 475                 480

 aac tgt gga cat gcc gaa gat gcc agc gtg aca tgc aac aga cac tga     1904
 Asn Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys Asn Arg His 
                 485                 490                 495

 aagtgggcag agcccaagtt cggggtcctg cacagagcac ccttcctgca tccctggggt   1964

 ggggcacagc tcggggccat cctgaccatg cctcgaccac accccgtcca gcattctcag   2024

 tcctcacacc tgcatcccag gaccgtgggg gccggtcgtc atttccctct tgaacatgtg   2084

 ctccgaagta taactctggg acctactgcc cgtctctctc ttccaccagg ttcctgcatg   2144

 aggagccctg atcaactgga tcaccacttt gcccagcctc tgaacaccat gcaccaggcc   2204

 tcaatatccc agttcccttt ggccttttag ttacaggtga atgctgagaa tgtgtcagag   2264

 acaagtgcag cagcagcgat ggttggtagt atagatcatt tactcttcag acaattccca   2324

 aacctccatt agtccaagag tttctacatc ttcctcccca gcaagaggca acgtcaagtg   2384

 atgaatttcc cccctttact ctgcctctgc tccccatttg ctagtttgag gaagtgacat   2444

 agaggagaag ccagctgtag gggcaagagg gaaatgcaag tcacctgcag gaatccagct   2504

 agatttggag aagggaatga aactaacatt gaatgactac catggcacgc taaatagtat   2564

 cttgggtgcc aaattcatgt atccacttag ctgcattggt ccagggcatg tcagtctgga   2624

 tacagcctta cctccaggta gcacttaact ggtccattca cctagactgc aagtaagaag   2684

 acaaaatgac tgagaccgtg tgcccacctg aacttattgt ctttacttgg cctgagctaa   2744

 aagcttgggt gcaggacctg tgtaactaga aagttgccta cttcagaacc tccagggcgt   2804

 gagtgcaagg tcaaacatga ctggcttcag gccgaccatc aatgtangaa gagagctgat   2864

 gntgaggctg acatgacggc t                                             2885




      <210> 177
      <211> 1891
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (603)..(866)

      <400> 177
 tttcacattt acatcacttt tattacagtg cactgttata attgttctat ttgcagttat     60

 tgtttatctc ttgctgtccc tgatttataa atagaacttt atcataggta tatatgtata    120

 ggaaaaaaca gtgtatagag gtgtctatac tatccatggt ttcagacgtt cactgggggt    180

 cttggaacgt atgtcccatg ggtaagaggg aactactata ttttctaatt ctatacattt    240

 cttattgctt atctgtcctg tcattctgcc cttgaatatt acacacacaa aaaaatcaag    300

 ctgacaaaaa gctattagac tactttttac tactaaaatg aagaaaatta attttatgaa    360

 tctggctcac actgaaagaa tatttattaa cactaccaat cagagatcca atgacagaaa    420

 cactgtctgg aatacaaaaa gaacaaaaaa tgaggtcatt tgaattgccc tgaaaaactc    480

 caaattcttc aagatggtgt acttgtatct atattctgaa gtactagtgt tttaatttta    540

 actaaaaatt aaataagagt ttgttttttt tttttttgag acggagtctt tctctgtcac    600

 cc   atg ctg gag tgc agt ggc aca atc ttg gct cat tgt aac ctc cac     647
      Met Leu Glu Cys Ser Gly Thr Ile Leu Ala His Cys Asn Leu His
        1               5                  10                  15

 ctc cca ggt tca agc aat gct cct gcc tca gcc tcc cga gta gct agg      695
 Leu Pro Gly Ser Ser Asn Ala Pro Ala Ser Ala Ser Arg Val Ala Arg
                  20                  25                  30

 att aca ggc gca cac cac cac gcc agg cta att ttt gta ttt tta gta      743
 Ile Thr Gly Ala His His His Ala Arg Leu Ile Phe Val Phe Leu Val
              35                  40                  45

 gag atg ggg ttt cac caa act gct ggc cat gct ggt ctt gaa ctc ctg      791
 Glu Met Gly Phe His Gln Thr Ala Gly His Ala Gly Leu Glu Leu Leu
          50                  55                  60

 aca tca ggt gat atg ccc gcc ttg gcc tcc caa agt gct ggg att aca      839
 Thr Ser Gly Asp Met Pro Ala Leu Ala Ser Gln Ser Ala Gly Ile Thr
      65                  70                  75

 ggc atg agc cac agc acc tgg ccg taa atgag agtttttatg tgcaagtaaa      891
 Gly Met Ser His Ser Thr Trp Pro 
  80                  85

 ggcagttaaa taactttcag taataaaatg catcacaata tttcacaggt ttaaaacaca    951

 acctggttac ctttttgaat aaaataacat ttggaagaag gcatagctac ttttaaaagc   1011

 tattctatgc tttccttgtg tttgaaattt caagaaaaaa taaaatgata aatcacaaaa   1071

 ttaaaaatgc caaattcaag ttaattccta taattcttcc attttgttat gaatattctg   1131

 taatatcaaa cattcatttt taatgtgcta aaaatatggg tttacaaaat atgaacaggt   1191

 aatttttaaa gagtaaatta tgttaagaac tttattattt tcgattcatt ttatagggta   1251

 gtaaaataat acttcttcaa aatcatttaa atgttattga tgccattgca aaatcattat   1311

 aaataaattt tctccattat ccaatcacat ctagataaca ttgaatatgt acaggtttct   1371

 ctggataggt accaaaaggt accacatttt atacagactt aattgtgaaa gctgggtgaa   1431

 ataaattttc agatcaaaat tttttttaag tttaaatcat tcactcttta aatttcagac   1491

 agtgtcagtg tgactcttac ttttaaagga aaaaaattag tttaaaattt aatagccaca   1551

 gatttaataa ttttttactt taacacttaa tgtacatttt catgagcagt aattaagata   1611

 tgttgaaatt ttaaatgtga aagatttcaa agtttcagta tgttaacatt actcttcaaa   1671

 tgttcttaat atatatataa acacttacaa attatagata caactagttg tatatctaca   1731

 atacatatat gaacaccatt cttcttctct agccatattt atatgaggat aaagtaataa   1791

 atctctgtgc tattcaagga aaaaaaatga atgctttaaa aaataaatcc ctcgtgccga   1851

 attcttgcct cgagggccaa attccctata gtgagtcgta                         1891




      <210> 178
      <211> 2707
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (3)..(1820)

      <400> 178
 gt   atg tat gca ctg tac agg aaa aaa cat aat gga tat agg gtt aag      47
      Met Tyr Ala Leu Tyr Arg Lys Lys His Asn Gly Tyr Arg Val Lys
        1               5                  10                  15

 tat gat tca gag ttt cag gca tcc atg gtg tgg ggg gtg tct tgg aac       95
 Tyr Asp Ser Glu Phe Gln Ala Ser Met Val Trp Gly Val Ser Trp Asn
                  20                  25                  30

 ata tcg ccc ata gat gag gga tta ctg tat att tat aaa aga cat aag      143
 Ile Ser Pro Ile Asp Glu Gly Leu Leu Tyr Ile Tyr Lys Arg His Lys
              35                  40                  45

 gaa ttt act act gaa gta gac aaa ggg tgt gag aca aac ata caa atg      191
 Glu Phe Thr Thr Glu Val Asp Lys Gly Cys Glu Thr Asn Ile Gln Met
          50                  55                  60

 aaa gat gat aaa atc aag aaa gtt gac aat cat cta cag atg cac tca      239
 Lys Asp Asp Lys Ile Lys Lys Val Asp Asn His Leu Gln Met His Ser
      65                  70                  75

 caa aag caa aga tgt ctg aag aga gtg gaa caa tgc cat aaa cat aat      287
 Gln Lys Gln Arg Cys Leu Lys Arg Val Glu Gln Cys His Lys His Asn
  80                  85                  90                  95

 gca ttt gga aac atc att cat cag agg aaa agt gat ttt cct tta agg      335
 Ala Phe Gly Asn Ile Ile His Gln Arg Lys Ser Asp Phe Pro Leu Arg
                 100                 105                 110

 caa aat cat gat aca ttt gac tta cat ggg aaa ata ctg aaa tca aat      383
 Gln Asn His Asp Thr Phe Asp Leu His Gly Lys Ile Leu Lys Ser Asn
             115                 120                 125

 tta agt tta gtc aac cag aac aaa agg tat gaa atc aag aat tct gtg      431
 Leu Ser Leu Val Asn Gln Asn Lys Arg Tyr Glu Ile Lys Asn Ser Val
         130                 135                 140

 ggg gtt aat gga gat ggg aaa tcc ttc ctt cat gcc aag cat gaa caa      479
 Gly Val Asn Gly Asp Gly Lys Ser Phe Leu His Ala Lys His Glu Gln
     145                 150                 155

 ttt cat aat gaa atg aac ttc ccc gaa ggt gga aat tct gtg aat aca      527
 Phe His Asn Glu Met Asn Phe Pro Glu Gly Gly Asn Ser Val Asn Thr
 160                 165                 170                 175

 aat tca caa ttc att aag cat cag cga act caa aac ata gat aaa ccc      575
 Asn Ser Gln Phe Ile Lys His Gln Arg Thr Gln Asn Ile Asp Lys Pro
                 180                 185                 190

 cat gta tgc act gag tgt ggg aag gct ttc ctc aag aag tct cgc ctc      623
 His Val Cys Thr Glu Cys Gly Lys Ala Phe Leu Lys Lys Ser Arg Leu
             195                 200                 205

 atc tat cat cag aga gtt cac act ggg gag aaa cct cat gga tgc agt      671
 Ile Tyr His Gln Arg Val His Thr Gly Glu Lys Pro His Gly Cys Ser
         210                 215                 220

 ata tgt ggg aaa gcc ttc tcc aga aag tcc ggg ctc act gaa cac cag      719
 Ile Cys Gly Lys Ala Phe Ser Arg Lys Ser Gly Leu Thr Glu His Gln
     225                 230                 235

 aga aac cac aca gga gag aaa ccc tat gaa tgc act gaa tgt gac aaa      767
 Arg Asn His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Asp Lys
 240                 245                 250                 255

 gca ttc cgc tgg aaa tca cag ctc aat gca cac cag aaa att cat aca      815
 Ala Phe Arg Trp Lys Ser Gln Leu Asn Ala His Gln Lys Ile His Thr
                 260                 265                 270

 gga gag aag tca tat ata tgc agt gat tgt gga aaa ggc ttc atc aag      863
 Gly Glu Lys Ser Tyr Ile Cys Ser Asp Cys Gly Lys Gly Phe Ile Lys
             275                 280                 285

 aag tct cgg ctc att aat cat cag aga gtt cat aca gga gag aaa cca      911
 Lys Ser Arg Leu Ile Asn His Gln Arg Val His Thr Gly Glu Lys Pro
         290                 295                 300

 cat gga tgc agc ctg tgt ggg aag gcc ttc tcc aaa agg tcc agg ctc      959
 His Gly Cys Ser Leu Cys Gly Lys Ala Phe Ser Lys Arg Ser Arg Leu
     305                 310                 315

 act gaa cac cag aga act cat aca gga gag aaa ccc tat gaa tgc act     1007
 Thr Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Thr
 320                 325                 330                 335

 gaa tgt gac aaa gca ttc cgc tgg aaa tca cag ctc aat gca cat cag     1055
 Glu Cys Asp Lys Ala Phe Arg Trp Lys Ser Gln Leu Asn Ala His Gln
                 340                 345                 350

 aaa gct cac aca gga gag aag tca tat ata tgc cgt gat tgt gga aaa     1103
 Lys Ala His Thr Gly Glu Lys Ser Tyr Ile Cys Arg Asp Cys Gly Lys
             355                 360                 365

 ggc ttc att cag aag gga aat ctc att gta cat cag cga att cat act     1151
 Gly Phe Ile Gln Lys Gly Asn Leu Ile Val His Gln Arg Ile His Thr
         370                 375                 380

 gga gaa aaa ccc tat ata tgc aat gaa tgt gga aaa ggc ttc atc caa     1199
 Gly Glu Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Gly Phe Ile Gln
     385                 390                 395

 aag ggc aac ctc ctt att cat cga cgt act cac act gga gag aaa ccc     1247
 Lys Gly Asn Leu Leu Ile His Arg Arg Thr His Thr Gly Glu Lys Pro
 400                 405                 410                 415

 tat gta tgc aat gaa tgt ggg aaa ggc ttc agc cag aag aca tgt tta     1295
 Tyr Val Cys Asn Glu Cys Gly Lys Gly Phe Ser Gln Lys Thr Cys Leu
                 420                 425                 430

 ata tcc cat cag aga ttt cac aca gga aag aca ccc ttt gta tgt act     1343
 Ile Ser His Gln Arg Phe His Thr Gly Lys Thr Pro Phe Val Cys Thr
             435                 440                 445

 gag tgt gga aaa tcc tgc tca cac aag tca ggt ctc att aac cac cag     1391
 Glu Cys Gly Lys Ser Cys Ser His Lys Ser Gly Leu Ile Asn His Gln
         450                 455                 460

 aga att cac aca gga gag aaa ccc tat aca tgc agt gac tgt ggg aaa     1439
 Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Ser Asp Cys Gly Lys
     465                 470                 475

 gct ttc aga gat aaa tca tgt ctc aac aga cat cgg aga act cat aca     1487
 Ala Phe Arg Asp Lys Ser Cys Leu Asn Arg His Arg Arg Thr His Thr
 480                 485                 490                 495

 ggg gag aga ccg tat gga tgc tct gat tgt ggg aaa gct ttc tcc cac     1535
 Gly Glu Arg Pro Tyr Gly Cys Ser Asp Cys Gly Lys Ala Phe Ser His
                 500                 505                 510

 ttg tca tgc ctt gtt tat cat aag gga atg ctg cat gca aga gag aaa     1583
 Leu Ser Cys Leu Val Tyr His Lys Gly Met Leu His Ala Arg Glu Lys
             515                 520                 525

 tgt gta ggt tca gtc aaa ttg gaa aat cct tgc tca gag agt cat agc     1631
 Cys Val Gly Ser Val Lys Leu Glu Asn Pro Cys Ser Glu Ser His Ser
         530                 535                 540

 tta tca cat aca cgt gat ctc ata cag gat aaa gac tct gtt aac atg     1679
 Leu Ser His Thr Arg Asp Leu Ile Gln Asp Lys Asp Ser Val Asn Met
     545                 550                 555

 gtg act ctg cag atg cct tct gtg gca gct cag acc tca tta act aac     1727
 Val Thr Leu Gln Met Pro Ser Val Ala Ala Gln Thr Ser Leu Thr Asn
 560                 565                 570                 575

 agt gcg ttc caa gca gag agc aaa gta gcc att gtg agc cag cct gtt     1775
 Ser Ala Phe Gln Ala Glu Ser Lys Val Ala Ile Val Ser Gln Pro Val
                 580                 585                 590

 gcc aga agt tca gtc tca gca gat agt aga att tgc aca gaa taa aaa     1823
 Ala Arg Ser Ser Val Ser Ala Asp Ser Arg Ile Cys Thr Glu 
             595                 600                 605

 ccatatgaat gcagtgaatg tggtagtgct ttcagtgatc aattacatca tatgtcacaa   1883

 aaaaacacag aggaacaaac tgatatattc aaggtggaaa gcccttgaat aaaaccttat   1943

 ggctaataag catatactca gagaaaaata gtatgaagtg gagactggga aattctttta   2003

 tgggaagata gatcttctca tcagtgacca tagatcacat cttcagtgag cttatagttg   2063

 gtagaaatat aatgatcatg gaaaagtcct tgttcagaaa cagtacgcca gtaggtatca   2123

 gggggtttac acaggagaga aacttttgga agacctttga aggctatgaa tgtggcaggg   2183

 ttgctagtgg tacattctgc cttatcctca gagggaatca tatagaaata aaactatgaa   2243

 aatgtaacta gaacatcttc atcaaaatat gaaagaacac acgaagcaaa taagccctgt   2303

 gaaaaggagt attttagaga tttcgatcag aaatctaaca tcattatatg gcagataata   2363

 tacaggatgt gtattttagg acaatatacc ttgaatcact agttgatatg tcaatgacta   2423

 attaaaaggg gttgtcagtg ttacacatca ttggttaaat ttatagcaca atgtacctct   2483

 tccccctttt ttgataagag tcttctattc ccaaccaaga tcattatatg attagctctt   2543

 gtgtttcttt gattccaaat ttcttcactt gttatttcag actactgaag ctcttcaaaa   2603

 ggaaaaatgt atttaattta ataatgtaac acaacaagtt tggatgtgtt taactttata   2663

 aataatcacc ccagaggaat gaagttcaaa acttgtgaat aacc                    2707




      <210> 179
      <211> 2334
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2334)

      <400> 179
  atg ctc aag ctg caa gac ctc tac aca tct cca tgt gct gaa act cct      48
  Met Leu Lys Leu Gln Asp Leu Tyr Thr Ser Pro Cys Ala Glu Thr Pro
    1               5                  10                  15

 cca agc aca ctg tca ggg act ctg tgg gag aga agc tgc cgg aca atc       96
 Pro Ser Thr Leu Ser Gly Thr Leu Trp Glu Arg Ser Cys Arg Thr Ile
              20                  25                  30

 tgc cta atc ctt gac ttc atc gcc cgt ggc aga att gga aac cgc ccc      144
 Cys Leu Ile Leu Asp Phe Ile Ala Arg Gly Arg Ile Gly Asn Arg Pro
          35                  40                  45

 aca aac ctt ggc ata agg tgc aag acg gaa aca gta ggt gcc atc ggg      192
 Thr Asn Leu Gly Ile Arg Cys Lys Thr Glu Thr Val Gly Ala Ile Gly
      50                  55                  60

 ccg gtc cac cag cag ttg aag att ctc ccc aat gct gag ggc aaa aag      240
 Pro Val His Gln Gln Leu Lys Ile Leu Pro Asn Ala Glu Gly Lys Lys
  65                  70                  75                  80

 agg act gga gac cgc gcc cga acg aac cgg tct ccg gca ccg cgc ccc      288
 Arg Thr Gly Asp Arg Ala Arg Thr Asn Arg Ser Pro Ala Pro Arg Pro
                  85                  90                  95

 cac tcc acc ttg gcc acc aca ccc aca cac tcc cgc gtc cgc ccc gcg      336
 His Ser Thr Leu Ala Thr Thr Pro Thr His Ser Arg Val Arg Pro Ala
             100                 105                 110

 cgc tcc tac tat ttc gct atc ttc tca aac atg aca cgg gtc tcc tct      384
 Arg Ser Tyr Tyr Phe Ala Ile Phe Ser Asn Met Thr Arg Val Ser Ser
         115                 120                 125

 tca gtc aaa ggc cgc att ttt ccc cct ggg ttg gaa cac cgg atc ctc      432
 Ser Val Lys Gly Arg Ile Phe Pro Pro Gly Leu Glu His Arg Ile Leu
     130                 135                 140

 gtg cct tgt tcg gag tca gcg ccc ctt gtg gtc cgg aag gga agt gac      480
 Val Pro Cys Ser Glu Ser Ala Pro Leu Val Val Arg Lys Gly Ser Asp
 145                 150                 155                 160

 gtt gtt gct ggg aag atg gcg acc gcg gcg act atc cca tcg gta gcc      528
 Val Val Ala Gly Lys Met Ala Thr Ala Ala Thr Ile Pro Ser Val Ala
                 165                 170                 175

 acg gcc aca gca gcg gct ctc ggc gag gtg gag gat gaa ggg ctc ctg      576
 Thr Ala Thr Ala Ala Ala Leu Gly Glu Val Glu Asp Glu Gly Leu Leu
             180                 185                 190

 gcg tcg ctg ttc cgg gac cgc ttc ccc gag gcc cag tgg cgc gag cgg      624
 Ala Ser Leu Phe Arg Asp Arg Phe Pro Glu Ala Gln Trp Arg Glu Arg
         195                 200                 205

 ccc gat gtg ggc cgc tac ctc cgg gag ttg agc ggc tcg ggg ctg gag      672
 Pro Asp Val Gly Arg Tyr Leu Arg Glu Leu Ser Gly Ser Gly Leu Glu
     210                 215                 220

 cgg ctg cgg cgc gag ccc gag cgc ctg gcg gag gag cgg gcg cag ctg      720
 Arg Leu Arg Arg Glu Pro Glu Arg Leu Ala Glu Glu Arg Ala Gln Leu
 225                 230                 235                 240

 ctg cag cag acg cgc gac ttg gcc ttc gct aac tac aag acc ttc atc      768
 Leu Gln Gln Thr Arg Asp Leu Ala Phe Ala Asn Tyr Lys Thr Phe Ile
                 245                 250                 255

 cgc ggc gcc gag tgc acc gag cgc atc cac cgc ctg ttt ggc gac gtg      816
 Arg Gly Ala Glu Cys Thr Glu Arg Ile His Arg Leu Phe Gly Asp Val
             260                 265                 270

 gag gcg tcg ctc ggc cgc ctg ctc gac cgt ttg ccc agc ttc cag cag      864
 Glu Ala Ser Leu Gly Arg Leu Leu Asp Arg Leu Pro Ser Phe Gln Gln
         275                 280                 285

 agc tgc agg aac ttt gtg aag gaa gcc gag gag atc agc tcc aac cgc      912
 Ser Cys Arg Asn Phe Val Lys Glu Ala Glu Glu Ile Ser Ser Asn Arg
     290                 295                 300

 cgg atg aat agc ctg acc cta aac cgg cac aca gaa att ttg gaa ata      960
 Arg Met Asn Ser Leu Thr Leu Asn Arg His Thr Glu Ile Leu Glu Ile
 305                 310                 315                 320

 ctg gag att cct cag ctc atg gac acc tgt gtc cgg aac agt tat tat     1008
 Leu Glu Ile Pro Gln Leu Met Asp Thr Cys Val Arg Asn Ser Tyr Tyr
                 325                 330                 335

 gaa gag gcc ctg gag ctt gca gcc tac gta cgc cga ctg gag agg aaa     1056
 Glu Glu Ala Leu Glu Leu Ala Ala Tyr Val Arg Arg Leu Glu Arg Lys
             340                 345                 350

 tac tct tcc atc cct gtc atc cag ggc atc gtg aac gaa gtg cgc cag     1104
 Tyr Ser Ser Ile Pro Val Ile Gln Gly Ile Val Asn Glu Val Arg Gln
         355                 360                 365

 tcc atg cag ctg atg ctg agc cag ctg atc cag caa ctg agg acc aac     1152
 Ser Met Gln Leu Met Leu Ser Gln Leu Ile Gln Gln Leu Arg Thr Asn
     370                 375                 380

 atc cag ctt cct gcc tgc ctc cgt gtc att ggc tac ctg cgg cgc atg     1200
 Ile Gln Leu Pro Ala Cys Leu Arg Val Ile Gly Tyr Leu Arg Arg Met
 385                 390                 395                 400

 gac gtc ttc act gag gct gag ttg agg gtg aag ttt ctt cag gcc cga     1248
 Asp Val Phe Thr Glu Ala Glu Leu Arg Val Lys Phe Leu Gln Ala Arg
                 405                 410                 415

 gat gct tgg ctc cgg tcc atc ctg act gcc att cct aat gat gat ccc     1296
 Asp Ala Trp Leu Arg Ser Ile Leu Thr Ala Ile Pro Asn Asp Asp Pro
             420                 425                 430

 tat ttc cat att aca aaa acc atc gag gcc tcc cgt gtc cat ctc ttt     1344
 Tyr Phe His Ile Thr Lys Thr Ile Glu Ala Ser Arg Val His Leu Phe
         435                 440                 445

 gat atc atc acc cag tac cgt gcc atc ttc tca gac gag gac cca ctg     1392
 Asp Ile Ile Thr Gln Tyr Arg Ala Ile Phe Ser Asp Glu Asp Pro Leu
     450                 455                 460

 ctg ccc cct gcc atg ggt gag cac act gtg aat gag agt gcc atc ttc     1440
 Leu Pro Pro Ala Met Gly Glu His Thr Val Asn Glu Ser Ala Ile Phe
 465                 470                 475                 480

 cat ggc tgg gtg cta cag aag gtc tca caa ttc ctg cag gtg ctg gag     1488
 His Gly Trp Val Leu Gln Lys Val Ser Gln Phe Leu Gln Val Leu Glu
                 485                 490                 495

 acc gac ctt tac cgg ggc ata ggc ggc cac ctg gac tct ctg ctg ggc     1536
 Thr Asp Leu Tyr Arg Gly Ile Gly Gly His Leu Asp Ser Leu Leu Gly
             500                 505                 510

 cag tgc atg tac ttt ggg ctg tcc ttc agc cgg gtg gga gct gat ttc     1584
 Gln Cys Met Tyr Phe Gly Leu Ser Phe Ser Arg Val Gly Ala Asp Phe
         515                 520                 525

 cgg ggt cag ttg gct cct gtt ttc cag cgg gtg gcc atc agc act ttc     1632
 Arg Gly Gln Leu Ala Pro Val Phe Gln Arg Val Ala Ile Ser Thr Phe
     530                 535                 540

 cag aaa gca att cag gaa aca gtg gag aaa ttc cag gaa gaa atg aac     1680
 Gln Lys Ala Ile Gln Glu Thr Val Glu Lys Phe Gln Glu Glu Met Asn
 545                 550                 555                 560

 tcc tac atg ctc atc tcg gct cca gcc atc ctg ggc acc agt aac atg     1728
 Ser Tyr Met Leu Ile Ser Ala Pro Ala Ile Leu Gly Thr Ser Asn Met
                 565                 570                 575

 cct gct gct gtg cca gcc acc cag ccg ggg acg ctg cag cca ccc atg     1776
 Pro Ala Ala Val Pro Ala Thr Gln Pro Gly Thr Leu Gln Pro Pro Met
             580                 585                 590

 gtg ctc cta gat ttc cca ccc ctc gcc tgc ttt ctc aac aat att ctg     1824
 Val Leu Leu Asp Phe Pro Pro Leu Ala Cys Phe Leu Asn Asn Ile Leu
         595                 600                 605

 gtt gcc ttc aat gat ctg cgc ctc tgc tgc cct gtg gcc ctg gcg cag     1872
 Val Ala Phe Asn Asp Leu Arg Leu Cys Cys Pro Val Ala Leu Ala Gln
     610                 615                 620

 gat gtg act ggg gcc ttg gaa gat gcc ctt gcc aag gta act aaa ata     1920
 Asp Val Thr Gly Ala Leu Glu Asp Ala Leu Ala Lys Val Thr Lys Ile
 625                 630                 635                 640

 atc ctg gcc ttc cat cgc gct gaa gag gct gcc ttc agc agc ggg gag     1968
 Ile Leu Ala Phe His Arg Ala Glu Glu Ala Ala Phe Ser Ser Gly Glu
                 645                 650                 655

 caa gag ctc ttt gtc cag ttc tgc act gtc ttc ctg gaa gac ctt gtt     2016
 Gln Glu Leu Phe Val Gln Phe Cys Thr Val Phe Leu Glu Asp Leu Val
             660                 665                 670

 ccg tat tta aat cgc tgt ctc caa gtc ctt ttt cca cca gct cag ata     2064
 Pro Tyr Leu Asn Arg Cys Leu Gln Val Leu Phe Pro Pro Ala Gln Ile
         675                 680                 685

 gca cag act tta ggc att cct ccc act cag ctc tcc aag tac ggt aac     2112
 Ala Gln Thr Leu Gly Ile Pro Pro Thr Gln Leu Ser Lys Tyr Gly Asn
     690                 695                 700

 cta ggg cat gtg aac atc ggc gcc att cag gag ccc ctc gcc ttt atc     2160
 Leu Gly His Val Asn Ile Gly Ala Ile Gln Glu Pro Leu Ala Phe Ile
 705                 710                 715                 720

 ctg cca aag aga gag acg ctt ttc acc ctg gat gac cag gcg ctg ggg     2208
 Leu Pro Lys Arg Glu Thr Leu Phe Thr Leu Asp Asp Gln Ala Leu Gly
                 725                 730                 735

 ccc gag ctc aca gct cca gca cca gag cct ccc gcc gag gag cca cgc     2256
 Pro Glu Leu Thr Ala Pro Ala Pro Glu Pro Pro Ala Glu Glu Pro Arg
             740                 745                 750

 ctg gag ccc gcg ggc cca gcc tgc ccg gag gga ggg cga gcg gag acg     2304
 Leu Glu Pro Ala Gly Pro Ala Cys Pro Glu Gly Gly Arg Ala Glu Thr
         755                 760                 765

 cag gcc gaa ccg ccc agc gtg ggg ccc tag                             2334
 Gln Ala Glu Pro Pro Ser Val Gly Pro 
     770                 775





      <210> 180
      <211> 1083
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (293)..(805)

      <400> 180
 cgcctgcacg accggtccgg aattcccggg tcgacccacg cgtccgaagg gcgaactgat     60

 ggccaaggcg agactacgaa tcccagcaag cagtacgcga cgcgaggacg caggaggagg    120

 agcccggagc tgcagccacc ggggagccag ggtctctgtc acccaggctg gagtgtagtg    180

 gcgcaatctc agctggctgg agccttgacc tccttgggct caagctatcc tcccacctca    240

 gcctctcaaa tagctgggac tacaggcagc aaagcacctg ctctgagtgg cc    atg     295
                                                              Met
                                                                1

 ggg aag cga tac ttc tgt gac tac tgc gac cgc tcc ttc cag gac aac      343
 Gly Lys Arg Tyr Phe Cys Asp Tyr Cys Asp Arg Ser Phe Gln Asp Asn
               5                  10                  15

 ctc cac aac cgc aag aag cac ctg aac ggg ctg cag cac ctc aag gcc      391
 Leu His Asn Arg Lys Lys His Leu Asn Gly Leu Gln His Leu Lys Ala
          20                  25                  30

 aag aag gtc tgg tac gac atg ttc cga gat gca gct gcc atc ttg ctg      439
 Lys Lys Val Trp Tyr Asp Met Phe Arg Asp Ala Ala Ala Ile Leu Leu
      35                  40                  45

 gat gag cag aac aag cgg ccc tgc agg aag ttt cta ctg aca ggc cag      487
 Asp Glu Gln Asn Lys Arg Pro Cys Arg Lys Phe Leu Leu Thr Gly Gln
  50                  55                  60                  65

 tgc gac ttt ggc tcc aac tgc aga ttt tcc cac atg tca gag cga gac      535
 Cys Asp Phe Gly Ser Asn Cys Arg Phe Ser His Met Ser Glu Arg Asp
                  70                  75                  80

 ctg cag gag ctg agc atc cag gtg gag gag gag agg cga gcc agg gag      583
 Leu Gln Glu Leu Ser Ile Gln Val Glu Glu Glu Arg Arg Ala Arg Glu
              85                  90                  95

 tgg cta cta gat gct cct gag ctc ccc gag ggc cat ctg gag gac tgg      631
 Trp Leu Leu Asp Ala Pro Glu Leu Pro Glu Gly His Leu Glu Asp Trp
         100                 105                 110

 ctg gag aag aga gcc aag cgg ctg agc tca gcc cca agt agc agg gct      679
 Leu Glu Lys Arg Ala Lys Arg Leu Ser Ser Ala Pro Ser Ser Arg Ala
     115                 120                 125

 gaa ccc atc aga acc act gtc ttc cag tac ccc gtg ggc tgg cca cca      727
 Glu Pro Ile Arg Thr Thr Val Phe Gln Tyr Pro Val Gly Trp Pro Pro
 130                 135                 140                 145

 gtt cag gag ctg cct cca tcc ctg cgg gca ccc cca cct ggg ggg tgg      775
 Val Gln Glu Leu Pro Pro Ser Leu Arg Ala Pro Pro Pro Gly Gly Trp
                 150                 155                 160

 cct ctg cag ccc aga gtc cag tgg ggc tga g ccccttgccc ccgactgacc      826
 Pro Leu Gln Pro Arg Val Gln Trp Gly 
             165                 170

 cccacgtggt cacttttctc atcagtcaca ataggaagcc aagcccggtt cctgctacgc    886

 cccatggagg ctccgagacc atctgcccag cctcactgag gctcaggaca cggccacacc    946

 aagtgcagcc ctcgtcctgg gtctgcaccg ggcagctctc ccctcactct cctccacctg   1006

 cccccctgct tcttaagaag atgggggaga aaacttccaa atgtttataa agaaagtctg   1066

 tcaccaaaaa aaaaaaa                                                  1083




      <210> 181
      <211> 1650
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1443)

      <400> 181
  atg atc tct gat caa gga cag tta act cac cac ctg act tct gca aac      48
  Met Ile Ser Asp Gln Gly Gln Leu Thr His His Leu Thr Ser Ala Asn
    1               5                  10                  15

 acg ctt aac aaa gac ttt ttt tgt gga gga cga ttg ggg cct gtg cag       96
 Thr Leu Asn Lys Asp Phe Phe Cys Gly Gly Arg Leu Gly Pro Val Gln
              20                  25                  30

 acc tgg tat cag cca cca gca ttt cag tgc aag ggt tta gcg gcg gcg      144
 Thr Trp Tyr Gln Pro Pro Ala Phe Gln Cys Lys Gly Leu Ala Ala Ala
          35                  40                  45

 gac gga gag ggg cct ctg cta ccc aag aag cag aag cgg ccg gcg acg      192
 Asp Gly Glu Gly Pro Leu Leu Pro Lys Lys Gln Lys Arg Pro Ala Thr
      50                  55                  60

 cgt cgc agg ctg gtg cac tat ctg aag ggc cgg gag gta gga gcg cgg      240
 Arg Arg Arg Leu Val His Tyr Leu Lys Gly Arg Glu Val Gly Ala Arg
  65                  70                  75                  80

 ggc cca gcc ggg ctc cag ggc ttc gag ggc gag ctg cgg ggc tac gcc      288
 Gly Pro Ala Gly Leu Gln Gly Phe Glu Gly Glu Leu Arg Gly Tyr Ala
                  85                  90                  95

 gtc cag agg ctg ccc gag ctg ctg acg gag cgc cag ctg gac ctg ggc      336
 Val Gln Arg Leu Pro Glu Leu Leu Thr Glu Arg Gln Leu Asp Leu Gly
             100                 105                 110

 acc ctc aac aag gtg ttc gcg tca cag tgg ctg aac gcc agg cag gtg      384
 Thr Leu Asn Lys Val Phe Ala Ser Gln Trp Leu Asn Ala Arg Gln Val
         115                 120                 125

 gtg tgc ggc acc aag tgt aat acg ctg ttt gtg gtg gac gtg cag tca      432
 Val Cys Gly Thr Lys Cys Asn Thr Leu Phe Val Val Asp Val Gln Ser
     130                 135                 140

 ggc cac atc acg cgc atc ccc ctc atg cgg gac aag gag gcc ggg ctg      480
 Gly His Ile Thr Arg Ile Pro Leu Met Arg Asp Lys Glu Ala Gly Leu
 145                 150                 155                 160

 gcc cag gcc cac cag ggc tgc ggc atc cat gcc atc gag ctg aat ccc      528
 Ala Gln Ala His Gln Gly Cys Gly Ile His Ala Ile Glu Leu Asn Pro
                 165                 170                 175

 tcc aag acg ctt ctg gcc acc ggc ggc gaa aac ccc aac agc ctg gcc      576
 Ser Lys Thr Leu Leu Ala Thr Gly Gly Glu Asn Pro Asn Ser Leu Ala
             180                 185                 190

 atc tac cag ctg ccc acc ctg gac ccc ctg tgc ctg ggc gac cgc cat      624
 Ile Tyr Gln Leu Pro Thr Leu Asp Pro Leu Cys Leu Gly Asp Arg His
         195                 200                 205

 ggc cac aag gac tgg atc ttc gca gtc gcc tgg ctg agt gac acc gta      672
 Gly His Lys Asp Trp Ile Phe Ala Val Ala Trp Leu Ser Asp Thr Val
     210                 215                 220

 gct gtg agc ggc tcc cgc gac ggc acc gtg gct ctg tgg cgg atg gac      720
 Ala Val Ser Gly Ser Arg Asp Gly Thr Val Ala Leu Trp Arg Met Asp
 225                 230                 235                 240

 cca gac atg ttt aat ggc agc att gcc tgg cac agc gag gtg ggt ctc      768
 Pro Asp Met Phe Asn Gly Ser Ile Ala Trp His Ser Glu Val Gly Leu
                 245                 250                 255

 cca gta tat gcc cac atc cgt ccg agg gat gtg gag gcc atc ccc agg      816
 Pro Val Tyr Ala His Ile Arg Pro Arg Asp Val Glu Ala Ile Pro Arg
             260                 265                 270

 gcc agc acc aac ccc agc aac cgc aag gta cgg gcc ctg gcc ttc agc      864
 Ala Ser Thr Asn Pro Ser Asn Arg Lys Val Arg Ala Leu Ala Phe Ser
         275                 280                 285

 ggc aag aac cag gag ctg gga gcg gtg tcc ttg gac ggc tac ttc cac      912
 Gly Lys Asn Gln Glu Leu Gly Ala Val Ser Leu Asp Gly Tyr Phe His
     290                 295                 300

 ctg tgg aaa gcc cgg agc aca cta tcc agg ctc ctg tcc atc agg ctg      960
 Leu Trp Lys Ala Arg Ser Thr Leu Ser Arg Leu Leu Ser Ile Arg Leu
 305                 310                 315                 320

 ccc tac tgc cga gag aat gtg tgc ctg acc tac tgt gat gag ttg tcc     1008
 Pro Tyr Cys Arg Glu Asn Val Cys Leu Thr Tyr Cys Asp Glu Leu Ser
                 325                 330                 335

 ctg tac gct gtg ggc tct cag tcc cac gtc tcc ttc ctg gat ccg cgc     1056
 Leu Tyr Ala Val Gly Ser Gln Ser His Val Ser Phe Leu Asp Pro Arg
             340                 345                 350

 cag cgc cag cag aac atc cgg ccc ctg tgc tct cga gag ggt ggc aca     1104
 Gln Arg Gln Gln Asn Ile Arg Pro Leu Cys Ser Arg Glu Gly Gly Thr
         355                 360                 365

 ggc gtg cgg tcg ctg agc ttc tac cag cac atc atc act gtg ggc acc     1152
 Gly Val Arg Ser Leu Ser Phe Tyr Gln His Ile Ile Thr Val Gly Thr
     370                 375                 380

 ggc cat ggt tcc ctg ctc ttc tat gac atc cgc gcc cag aag ttc ctg     1200
 Gly His Gly Ser Leu Leu Phe Tyr Asp Ile Arg Ala Gln Lys Phe Leu
 385                 390                 395                 400

 gag gag agg gcc tct tcc agc ctg gac tcc atg ccg ggg ccc gca ggg     1248
 Glu Glu Arg Ala Ser Ser Ser Leu Asp Ser Met Pro Gly Pro Ala Gly
                 405                 410                 415

 agg aag ctc aag ctt gcc tgc ggc aga ggc tgg ctc aac caa gat gac     1296
 Arg Lys Leu Lys Leu Ala Cys Gly Arg Gly Trp Leu Asn Gln Asp Asp
             420                 425                 430

 gtc tgg gtg aac tac ttt ggt ggc atg gga gag ttc ccc aat gcg ctc     1344
 Val Trp Val Asn Tyr Phe Gly Gly Met Gly Glu Phe Pro Asn Ala Leu
         435                 440                 445

 tac acc cac tgc tac aac tgg ccg gag atg aag ctc ttt gtg gct ggg     1392
 Tyr Thr His Cys Tyr Asn Trp Pro Glu Met Lys Leu Phe Val Ala Gly
     450                 455                 460

 ggg cct ctc cct tca ggc ctc cat ggg aac tac gca ggc ctc tgg agt     1440
 Gly Pro Leu Pro Ser Gly Leu His Gly Asn Tyr Ala Gly Leu Trp Ser
 465                 470                 475                 480

 taa ggat ggacgccttg ttctcaaagt gcacaggtgg aaccagtcca acttacgtgt     1497
 


 gcttaatgta ttaggcagag aaagaaagag agagagcggg agcgagagag cacaagtggt   1557

 cctttcggca gtcaaaactt tggctttaaa actctcattc acgtttccca acagcagtat   1617

 atttttgcct tctcattcac agagttttgg cta                                1650




      <210> 182
      <211> 3230
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (218)..(1693)

      <400> 182
 cccgctgacg cccccgaccc tgccgccttc ttcgtccgcc tccagaggcg cccgacgtcc     60

 cgacagctcc tggagtgaga ccaggactga gaacagggag aggcgacccg acccccaggg    120

 cccggtgctc aggacagcac acagagccgc tgaaaacgac tgaagagagc aagggatttc    180

 ctgggacatc tggctctgga gagtaaaagg ccaagct atg ata gca act ggt gga     235
                                          Met Ile Ala Thr Gly Gly
                                            1               5

 gtg ata act ggc ctg gcc gcc ttg aaa agg caa gac tct gcc aga tca      283
 Val Ile Thr Gly Leu Ala Ala Leu Lys Arg Gln Asp Ser Ala Arg Ser
              10                  15                  20

 cag cag cat gtc aac ctc agc ccg tct cct gct acc caa gag aag aag      331
 Gln Gln His Val Asn Leu Ser Pro Ser Pro Ala Thr Gln Glu Lys Lys
          25                  30                  35

 ccc atc agg cgc cgg ccc cgg gca gat gtt gtg gtt gtt cgt ggc aaa      379
 Pro Ile Arg Arg Arg Pro Arg Ala Asp Val Val Val Val Arg Gly Lys
      40                  45                  50

 atc cgg ctt tat tcc cca tct ggt ttt ttt ctt att tta gga gtg ctc      427
 Ile Arg Leu Tyr Ser Pro Ser Gly Phe Phe Leu Ile Leu Gly Val Leu
  55                  60                  65                  70

 atc tcc att ata gga att gct atg gcc gtt ctt gga tat tgg ccc caa      475
 Ile Ser Ile Ile Gly Ile Ala Met Ala Val Leu Gly Tyr Trp Pro Gln
                  75                  80                  85

 aaa gaa cat ttt att gat gct gaa aca aca ctg tca aca aat gaa act      523
 Lys Glu His Phe Ile Asp Ala Glu Thr Thr Leu Ser Thr Asn Glu Thr
              90                  95                 100

 cag gtc att cgg aat gaa ggc ggt gtg gtg gtt cgc ttc ttt gag cag      571
 Gln Val Ile Arg Asn Glu Gly Gly Val Val Val Arg Phe Phe Glu Gln
         105                 110                 115

 cat ttg cat tct gat aag atg aaa atg ctt ggc cca ttc acc atg ggg      619
 His Leu His Ser Asp Lys Met Lys Met Leu Gly Pro Phe Thr Met Gly
     120                 125                 130

 att ggc att ttc att ttc att tgt gct aat gcc att ctt cat gaa aac      667
 Ile Gly Ile Phe Ile Phe Ile Cys Ala Asn Ala Ile Leu His Glu Asn
 135                 140                 145                 150

 cgt gac aaa gag acc aaa atc ata cac atg agg gat atc tat tcc aca      715
 Arg Asp Lys Glu Thr Lys Ile Ile His Met Arg Asp Ile Tyr Ser Thr
                 155                 160                 165

 gtc att gac att cac acg cta aga atc aag gag caa agg caa atg aac      763
 Val Ile Asp Ile His Thr Leu Arg Ile Lys Glu Gln Arg Gln Met Asn
             170                 175                 180

 ggc atg tac act ggt ttg atg gga gaa aca gaa gta aaa cag aat ggg      811
 Gly Met Tyr Thr Gly Leu Met Gly Glu Thr Glu Val Lys Gln Asn Gly
         185                 190                 195

 agc tcc tgt gcc tcg aga ttg gca gca aat acg atc gcc tct ttc tcg      859
 Ser Ser Cys Ala Ser Arg Leu Ala Ala Asn Thr Ile Ala Ser Phe Ser
     200                 205                 210

 ggt ttt cgg agc agt ttt cga atg gac agc tcc gtg gag gag gat gaa      907
 Gly Phe Arg Ser Ser Phe Arg Met Asp Ser Ser Val Glu Glu Asp Glu
 215                 220                 225                 230

 ctt atg tta aat gaa ggt aag agt tct ggg cat ctt atg ccc cct ttg      955
 Leu Met Leu Asn Glu Gly Lys Ser Ser Gly His Leu Met Pro Pro Leu
                 235                 240                 245

 ctc tct gac agc tct gtg tct gtc ttt ggc ctc tat cca cct cct tcc     1003
 Leu Ser Asp Ser Ser Val Ser Val Phe Gly Leu Tyr Pro Pro Pro Ser
             250                 255                 260

 aag aca act gat gat aag acc agc ggc tct aag aaa tgt gaa acc aag     1051
 Lys Thr Thr Asp Asp Lys Thr Ser Gly Ser Lys Lys Cys Glu Thr Lys
         265                 270                 275

 tca att gtg tca tcg tcc atc agt gct ttt aca ttg cct gtg atc aaa     1099
 Ser Ile Val Ser Ser Ser Ile Ser Ala Phe Thr Leu Pro Val Ile Lys
     280                 285                 290

 ctt aat aac tgt gtt att gat gag ccc agt ata gat aac atc act gaa     1147
 Leu Asn Asn Cys Val Ile Asp Glu Pro Ser Ile Asp Asn Ile Thr Glu
 295                 300                 305                 310

 gat gct gac aac ctc aaa agt agg tca agg aat ttg tca atg gat tcc     1195
 Asp Ala Asp Asn Leu Lys Ser Arg Ser Arg Asn Leu Ser Met Asp Ser
                 315                 320                 325

 ctt gtg gtt cct ttg ccc aac acc agt gaa tcc ttc cag ccc gtc agc     1243
 Leu Val Val Pro Leu Pro Asn Thr Ser Glu Ser Phe Gln Pro Val Ser
             330                 335                 340

 aca gtg cta cca agg aat aat tcc att ggg gag tcg ttg tcg agt cag     1291
 Thr Val Leu Pro Arg Asn Asn Ser Ile Gly Glu Ser Leu Ser Ser Gln
         345                 350                 355

 tac aag tca tct atg gct ctc gga cct ggg gct gga cag ctc ttg tct     1339
 Tyr Lys Ser Ser Met Ala Leu Gly Pro Gly Ala Gly Gln Leu Leu Ser
     360                 365                 370

 cct ggg gct gcc aga aga cag ttt ggg tcc aat aca tcc ttg cat ttg     1387
 Pro Gly Ala Ala Arg Arg Gln Phe Gly Ser Asn Thr Ser Leu His Leu
 375                 380                 385                 390

 ctc tcg tca cac tca aag tcc ttg gac tta gac cgg ggt ccc tcc act     1435
 Leu Ser Ser His Ser Lys Ser Leu Asp Leu Asp Arg Gly Pro Ser Thr
                 395                 400                 405

 cta act gtt cag gca gaa caa cgg aaa cat cca agt tgg cct agg ttg     1483
 Leu Thr Val Gln Ala Glu Gln Arg Lys His Pro Ser Trp Pro Arg Leu
             410                 415                 420

 gat cgg aac aac agc aag gga tat atg aaa cta gag aac aaa gaa gac     1531
 Asp Arg Asn Asn Ser Lys Gly Tyr Met Lys Leu Glu Asn Lys Glu Asp
         425                 430                 435

 ccg atg gat agg ttg ctt gtg ccc caa gtt gcc atc aaa aag gac ttt     1579
 Pro Met Asp Arg Leu Leu Val Pro Gln Val Ala Ile Lys Lys Asp Phe
     440                 445                 450

 acc aat aag gag aag ctt ctt atg att tca aga tct cac aat aat ttg     1627
 Thr Asn Lys Glu Lys Leu Leu Met Ile Ser Arg Ser His Asn Asn Leu
 455                 460                 465                 470

 agt ttt gaa cat gat gag ttt ttg agt aac aac cta aag agg gga act     1675
 Ser Phe Glu His Asp Glu Phe Leu Ser Asn Asn Leu Lys Arg Gly Thr
                 475                 480                 485

 tct gaa aca agg ttt taa tgttaa aagaatatat cattttacaa gggtatatat     1729
 Ser Glu Thr Arg Phe 
             490

 tttaaaacga ttttcactgg tgtttccttc ttaaagtatt ggctgtaagc ctttttaatc   1789

 aaatggtttg tagtgtatta gaattggctg cttagttctg taatgaagat ggttgtatgt   1849

 ttgggttact tgtgactgca gtactctatg ttaccacaca tgattttatt tttctcttcc   1909

 tttgaaagca tgatctcttt tattaatatg aatgcaaaat gcttgcatcc aaattaaagc   1969

 ttattttctt tacttttaag ttctttgatt gccctattca taaaatgaaa tgtccagtat   2029

 ggaaaacata gggtaccaaa gtgtggacca ggagtacaaa ttcagtccca atactcaata   2089

 cgtattatag atgactatga gtgcaaacct taggatgtga ttttctgaat aattgttctt   2149

 tgtaggattt ggttacatta tttaaaatga aaaagatcta gttttagtgt gagctcagta   2209

 atgttaattg gttaagttca ttgtgaatct tgagttttag ataagtagtt atttttttca   2269

 atatcacttc tgtttttagt gatattatat caagaaacaa cgtattcaag agccatggct   2329

 gacagtgcca gatatactta gggataaaca tcaaaatgca attatagttg ctataacgtt   2389

 agatactcgg aatcaaaatt tatttgcaag ctgacttgat aaactaaatg aaccaataaa   2449

 atttgtagaa atgctatcct gaaataatta tatacatgaa gacaatgttg actaatgaat   2509

 taagatacat tatatactag ttaatgctaa ctagtctcag tacctgtttt tagccatctg   2569

 ttactgtcca atagcacctc attcccacat tctattttcc cccggtattc tttagatcct   2629

 agtatttgga aaacaatcgg ctaaccttga catttctttt taccttcata tgccactatc   2689

 tcggtagttc aaaaaaattt agttcttgat aaattgcctt gaagtttacc ttgtgctgga   2749

 gagccttatg ataactccaa agactttctt acggtataat acatgttgtt taggattgtg   2809

 tttcttagtc actgaagata ataaatatta aaatggatgt tttcatcaga aaattttcat   2869

 gttttccttt aaggtaacat aattgtaaga attgtttaat aaaatactca ggaaattcta   2929

 aaggtttctc ctaataccta aacatttctg aacatcagta ttgcagttgt ggaagagcag   2989

 aaggaggata catttgtttg tgttgctccc caaaattcca ccttgcattt gcatcacaaa   3049

 cttccctcaa ttgaggcagt tttctttgtt agaacattaa gtctgtgtat tgtaatagag   3109

 tgggctcaat attttactat aaagcattta ataaactgtt attaatagaa gtttgtgttc   3169

 ttcacacctt tgctattgct ttttaaataa aatgtacatt tctgcttaaa aaaaaaaaaa   3229

 a                                                                   3230




      <210> 183
      <211> 1981
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (268)..(1812)

      <220>
      <221> misc_feature
      <222> (1)...(1981)
      <223> n = a,t,c or g

      <400> 183
 gcacgagttt cttttctctc ctcttctctc tctccttcct attttcattc tatctctttt     60

 cctcactctc tttttctccc ccttgaaggc actgttacta gaaatagaga gctctggggc    120

 ttgctgaagc catgggcagt caccactcca ggattcccct tttagcgcct cctccccatc    180

 ttaatctcaa agtccagcag gatagtgagc agttagagcc cggcctccaa tctgcttcca    240

 tgggggttgg ctttctgagt gggagaa    atg act cta atc tgg aga cat ttg     291
                                  Met Thr Leu Ile Trp Arg His Leu
                                    1               5

 ctg aga ccc ttg tgc ctg gtc act tcc gct ccc agg atc ctt gag atg      339
 Leu Arg Pro Leu Cys Leu Val Thr Ser Ala Pro Arg Ile Leu Glu Met
      10                  15                  20

 cat cct ttc ctg agc cta ggt act tcc cgg aca tca gta acc aag ctc      387
 His Pro Phe Leu Ser Leu Gly Thr Ser Arg Thr Ser Val Thr Lys Leu
  25                  30                  35                  40

 agt ctt cat aca aag ccc aga atg cct cca tgt gac ttc atg cct gaa      435
 Ser Leu His Thr Lys Pro Arg Met Pro Pro Cys Asp Phe Met Pro Glu
                  45                  50                  55

 aga tac cag tcc ctt ggc tac aac cgt gtc ctg gaa atc cac aag gaa      483
 Arg Tyr Gln Ser Leu Gly Tyr Asn Arg Val Leu Glu Ile His Lys Glu
              60                  65                  70

 cat ctt tct cct gtg gtg acg gca tat ttc cag aaa ccc ctg ctg ctc      531
 His Leu Ser Pro Val Val Thr Ala Tyr Phe Gln Lys Pro Leu Leu Leu
          75                  80                  85

 cac cag ggg cac atg gag tgg ctc ttt gat gct gaa gga agc aga tac      579
 His Gln Gly His Met Glu Trp Leu Phe Asp Ala Glu Gly Ser Arg Tyr
      90                  95                 100

 ctg gat ttt ttt tcc ggg att gtt act gtc agt gtt ggc cat tgc cac      627
 Leu Asp Phe Phe Ser Gly Ile Val Thr Val Ser Val Gly His Cys His
 105                 110                 115                 120

 cca aag gtg aat gca gtg gca caa aag cag ctc ggc cgc ctg tgg cat      675
 Pro Lys Val Asn Ala Val Ala Gln Lys Gln Leu Gly Arg Leu Trp His
                 125                 130                 135

 aca agc acc gtc ttc ttc cac cct cca atg cat gaa tat gca gag aag      723
 Thr Ser Thr Val Phe Phe His Pro Pro Met His Glu Tyr Ala Glu Lys
             140                 145                 150

 ctt gcc gca ctt ctt cct gag cct ctt aag gtc att ttc ttg gtg aac      771
 Leu Ala Ala Leu Leu Pro Glu Pro Leu Lys Val Ile Phe Leu Val Asn
         155                 160                 165

 agt ggc tca gaa gcc aat gag ctg gcc atg ctg atg gcc agg gcg cac      819
 Ser Gly Ser Glu Ala Asn Glu Leu Ala Met Leu Met Ala Arg Ala His
     170                 175                 180

 tca aac aac ata gac atc att tct ttc aga gga gcc tac cat gga tgc      867
 Ser Asn Asn Ile Asp Ile Ile Ser Phe Arg Gly Ala Tyr His Gly Cys
 185                 190                 195                 200

 agt cct tac aca ctt ggc ttg aca aac gta ggg acc tac aag atg gaa      915
 Ser Pro Tyr Thr Leu Gly Leu Thr Asn Val Gly Thr Tyr Lys Met Glu
                 205                 210                 215

 ctc cct ggt ggg aca ggt tgc caa cca aca atg tgt cca gat gtt ttt      963
 Leu Pro Gly Gly Thr Gly Cys Gln Pro Thr Met Cys Pro Asp Val Phe
             220                 225                 230

 cgt ggc cct tgg gga gga agc cac tgt cga gat tct cca gtg caa aca     1011
 Arg Gly Pro Trp Gly Gly Ser His Cys Arg Asp Ser Pro Val Gln Thr
         235                 240                 245

 atc agg aag tgc agc tgt gca cca gac tgc tgc caa gct aaa gat cag     1059
 Ile Arg Lys Cys Ser Cys Ala Pro Asp Cys Cys Gln Ala Lys Asp Gln
     250                 255                 260

 tat att gag caa ttc aaa gat acg ctg agc aca tct gtg gcc aag tca     1107
 Tyr Ile Glu Gln Phe Lys Asp Thr Leu Ser Thr Ser Val Ala Lys Ser
 265                 270                 275                 280

 att gct gga ttt ttc gca gaa cct att caa ggt gtg aat gga gtt gtc     1155
 Ile Ala Gly Phe Phe Ala Glu Pro Ile Gln Gly Val Asn Gly Val Val
                 285                 290                 295

 cag tac cca aag ggg ttt cta aag gaa gcc ttt gag ctg gtg cga gca     1203
 Gln Tyr Pro Lys Gly Phe Leu Lys Glu Ala Phe Glu Leu Val Arg Ala
             300                 305                 310

 agg gga ggc gtg tgc att gca gat gaa gtg cag aca gga ttt gga agg     1251
 Arg Gly Gly Val Cys Ile Ala Asp Glu Val Gln Thr Gly Phe Gly Arg
         315                 320                 325

 ttg ggc tct cac ttc tgg ggc ttc caa acc cac gat gtc ctg cct gac     1299
 Leu Gly Ser His Phe Trp Gly Phe Gln Thr His Asp Val Leu Pro Asp
     330                 335                 340

 att gtc acc atg gct aaa ggg att ggg aat ggc ttt ccc atg gca gca     1347
 Ile Val Thr Met Ala Lys Gly Ile Gly Asn Gly Phe Pro Met Ala Ala
 345                 350                 355                 360

 gtc ata acc act cca gag att gcc aaa tct ttg gcg aaa tgc ctg cag     1395
 Val Ile Thr Thr Pro Glu Ile Ala Lys Ser Leu Ala Lys Cys Leu Gln
                 365                 370                 375

 cac ttc aac acc ttt gga ggg aac ccc atg gcc tgt gcc att gga tct     1443
 His Phe Asn Thr Phe Gly Gly Asn Pro Met Ala Cys Ala Ile Gly Ser
             380                 385                 390

 gct gtg ctt gag gtg att aaa gaa gaa aat cta cag gaa aac agt caa     1491
 Ala Val Leu Glu Val Ile Lys Glu Glu Asn Leu Gln Glu Asn Ser Gln
         395                 400                 405

 gaa gtt ggg acc tac atg tta cta aag ttt gct aag ctg cgg gat gaa     1539
 Glu Val Gly Thr Tyr Met Leu Leu Lys Phe Ala Lys Leu Arg Asp Glu
     410                 415                 420

 ttt gaa att gtt gga gac gtc cga ggc aaa ggt ctc atg ata ggc ata     1587
 Phe Glu Ile Val Gly Asp Val Arg Gly Lys Gly Leu Met Ile Gly Ile
 425                 430                 435                 440

 gaa atg gtg cag gat aag ata agc tgt cgg cct ctt ccc cgt gaa gaa     1635
 Glu Met Val Gln Asp Lys Ile Ser Cys Arg Pro Leu Pro Arg Glu Glu
                 445                 450                 455

 gta aat cag atc cat gag gac tgc aag cac atg gga ctc ctc gtt ggc     1683
 Val Asn Gln Ile His Glu Asp Cys Lys His Met Gly Leu Leu Val Gly
             460                 465                 470

 aga ggc agc att ttt tct cag aca ttt cgc att gcg ccc tca atg tgc     1731
 Arg Gly Ser Ile Phe Ser Gln Thr Phe Arg Ile Ala Pro Ser Met Cys
         475                 480                 485

 atc act aaa cca gaa gtt gat ttt gca gta gaa gta ttt cgt tct gcc     1779
 Ile Thr Lys Pro Glu Val Asp Phe Ala Val Glu Val Phe Arg Ser Ala
     490                 495                 500

 tta acc caa cac atg gaa aga aga gct aag taa cattgtca gaaataaata     1830
 Leu Thr Gln His Met Glu Arg Arg Ala Lys 
 505                 510

 aaaccacaag tctcaagaat ttgccacgta tgttcaaggg tgaatttgaa gaatttcaga   1890

 accactggta tccagagaaa gcctgcagct ctccacagga gctgtaaaag tcatgggttg   1950

 antgcctacc caaccntttt tgtttggcgg g                                  1981




      <210> 184
      <211> 1673
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (268)..(1503)

      <220>
      <221> misc_feature
      <222> (1)...(1673)
      <223> n = a,t,c or g

      <400> 184
 gcacgagttt cttttctctc ctcttctctc tctccttcct attttcattc tatctctttt     60

 cctcactctc tttttctccc ccttgaaggc actgttacta gaaatagaga gctctggggc    120

 ttgctgaagc catgggcagt caccactcca ggattcccct tttagcgcct cctccccatc    180

 ttaatctcaa agtccagcag gatagtgagc agttagagcc cggcctccaa tctgcttcca    240

 tgggggttgg ctttctgagt gggagaa    atg act cta atc tgg aga cat ttg     291
                                  Met Thr Leu Ile Trp Arg His Leu
                                    1               5

 ctg aga ccc ttg tgc ctg gtc act tcc gct ccc agg atc ctt gag atg      339
 Leu Arg Pro Leu Cys Leu Val Thr Ser Ala Pro Arg Ile Leu Glu Met
      10                  15                  20

 cat cct ttc ctg agc cta ggt act tcc cgg aca tca gta acc aag ctc      387
 His Pro Phe Leu Ser Leu Gly Thr Ser Arg Thr Ser Val Thr Lys Leu
  25                  30                  35                  40

 agt ctt cat aca aag ccc aga atg cct cca tgt gac ttc atg cct gaa      435
 Ser Leu His Thr Lys Pro Arg Met Pro Pro Cys Asp Phe Met Pro Glu
                  45                  50                  55

 aga tac cag gtc att ttc ttg gtg aac agt ggc tca gaa gcc aat gag      483
 Arg Tyr Gln Val Ile Phe Leu Val Asn Ser Gly Ser Glu Ala Asn Glu
              60                  65                  70

 ctg gcc atg ctg atg gcc agg gcg cac tca aac aac ata gac atc att      531
 Leu Ala Met Leu Met Ala Arg Ala His Ser Asn Asn Ile Asp Ile Ile
          75                  80                  85

 tct ttc aga gga gcc tac cat gga tgc agt cct tac aca ctt ggc ttg      579
 Ser Phe Arg Gly Ala Tyr His Gly Cys Ser Pro Tyr Thr Leu Gly Leu
      90                  95                 100

 aca aac gta ggg atc tac aag atg gaa ctc cct ggt ggg aca ggt tgc      627
 Thr Asn Val Gly Ile Tyr Lys Met Glu Leu Pro Gly Gly Thr Gly Cys
 105                 110                 115                 120

 caa cca aca atg tgt cca gat gtt ttt cgt ggc cct tgg gga gga agc      675
 Gln Pro Thr Met Cys Pro Asp Val Phe Arg Gly Pro Trp Gly Gly Ser
                 125                 130                 135

 cac tgt cga gat tct cca gtg caa aca atc agg aag tgc agc tgt gca      723
 His Cys Arg Asp Ser Pro Val Gln Thr Ile Arg Lys Cys Ser Cys Ala
             140                 145                 150

 cca gac tgc tgc caa gct aaa gat cag tat att gag caa ttc aaa gat      771
 Pro Asp Cys Cys Gln Ala Lys Asp Gln Tyr Ile Glu Gln Phe Lys Asp
         155                 160                 165

 acg ctg agc aca tct gtg gcc aag tca att gct gga ttt ttc gca gaa      819
 Thr Leu Ser Thr Ser Val Ala Lys Ser Ile Ala Gly Phe Phe Ala Glu
     170                 175                 180

 cct att caa ggt gtg aat gga gtt gtc cag tac cca aag ggg ttt cta      867
 Pro Ile Gln Gly Val Asn Gly Val Val Gln Tyr Pro Lys Gly Phe Leu
 185                 190                 195                 200

 aag gaa gcc ttt gag ctg gtg cga gca agg gga ggc gtg tgc att gca      915
 Lys Glu Ala Phe Glu Leu Val Arg Ala Arg Gly Gly Val Cys Ile Ala
                 205                 210                 215

 gat gaa gtg cag aca gga ttt gga agg ttg ggc tct cac ttc tgg ggc      963
 Asp Glu Val Gln Thr Gly Phe Gly Arg Leu Gly Ser His Phe Trp Gly
             220                 225                 230

 ttc caa acc cac gat gtc ctg cct gac att gtc acc atg gct aaa ggg     1011
 Phe Gln Thr His Asp Val Leu Pro Asp Ile Val Thr Met Ala Lys Gly
         235                 240                 245

 att ggg aat ggc ttt ccc atg gca gca gtc ata acc act cca gag att     1059
 Ile Gly Asn Gly Phe Pro Met Ala Ala Val Ile Thr Thr Pro Glu Ile
     250                 255                 260

 gcc aaa tct ttg gcg aaa tgc ctg cag cac ttc aac acc ttt gga ggg     1107
 Ala Lys Ser Leu Ala Lys Cys Leu Gln His Phe Asn Thr Phe Gly Gly
 265                 270                 275                 280

 aac ccc atg gcc tgt gcc att gga tct gct gtg ctt gag gtg att aaa     1155
 Asn Pro Met Ala Cys Ala Ile Gly Ser Ala Val Leu Glu Val Ile Lys
                 285                 290                 295

 gaa gaa aat cta cag gaa aac agt caa gaa gtt ggg acc tac atg tta     1203
 Glu Glu Asn Leu Gln Glu Asn Ser Gln Glu Val Gly Thr Tyr Met Leu
             300                 305                 310

 cta aag ttt gct aag ctg cgg gat gaa ttt gaa att gtt gga gac gtc     1251
 Leu Lys Phe Ala Lys Leu Arg Asp Glu Phe Glu Ile Val Gly Asp Val
         315                 320                 325

 cga ggc aaa ggc ctc atg ata ggc ata gaa atg gtg cag gat aag ata     1299
 Arg Gly Lys Gly Leu Met Ile Gly Ile Glu Met Val Gln Asp Lys Ile
     330                 335                 340

 agc tgt cgg cct ctt ccc cgt gaa gaa gta aat cag atc cat gag gac     1347
 Ser Cys Arg Pro Leu Pro Arg Glu Glu Val Asn Gln Ile His Glu Asp
 345                 350                 355                 360

 tgc aag cac atg gga ctc ctc gtt ggc aga ggc agc att ttt tct cag     1395
 Cys Lys His Met Gly Leu Leu Val Gly Arg Gly Ser Ile Phe Ser Gln
                 365                 370                 375

 aca ttt cgc att gcg ccc tca atg tgc atc act aaa cca gaa gtt gat     1443
 Thr Phe Arg Ile Ala Pro Ser Met Cys Ile Thr Lys Pro Glu Val Asp
             380                 385                 390

 ttt gca gta gaa gta ttt cgt tct gcc tta acc caa cac atg gaa aga     1491
 Phe Ala Val Glu Val Phe Arg Ser Ala Leu Thr Gln His Met Glu Arg
         395                 400                 405

 aga gct aag taa cat tgtcagaaat aaataaaacc acaagtctca agaatttgcc     1546
 Arg Ala Lys 
     410

 acgtatgttc aagggtgaat ttgaagaatt tcagaaccac tggtatccag agaaagcctg   1606

 cagctctcca cagggngctg ttaaagtccn gggttgantg cctacccaac cntttttgtt   1666

 tggcggg                                                             1673




      <210> 185
      <211> 1076
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(987)

      <400> 185
  atg ctg atg tgc agg cag ccg atg aaa cga tgg aag gac aga aga aca      48
  Met Leu Met Cys Arg Gln Pro Met Lys Arg Trp Lys Asp Arg Arg Thr
    1               5                  10                  15

 ggc ctg ttg ctg cca ttg gtc ctc ctg ttg ttt ggg gca tgt agc tca       96
 Gly Leu Leu Leu Pro Leu Val Leu Leu Leu Phe Gly Ala Cys Ser Ser
              20                  25                  30

 ctg gca tgg gta tgt ggc cgg cga atg agt agc aga tcc caa caa ctt      144
 Leu Ala Trp Val Cys Gly Arg Arg Met Ser Ser Arg Ser Gln Gln Leu
          35                  40                  45

 aac aat gct tct gct atc gtg gaa ggc aaa cct gct tct gct atc gtg      192
 Asn Asn Ala Ser Ala Ile Val Glu Gly Lys Pro Ala Ser Ala Ile Val
      50                  55                  60

 gga ggc aaa cct gca aac atc ttg gag ttc ccc tgg cat gtg ggg att      240
 Gly Gly Lys Pro Ala Asn Ile Leu Glu Phe Pro Trp His Val Gly Ile
  65                  70                  75                  80

 atg aat cat ggt agt cat ctc tgt ggg gga tct att ctc aat gag tgg      288
 Met Asn His Gly Ser His Leu Cys Gly Gly Ser Ile Leu Asn Glu Trp
                  85                  90                  95

 tgg gtt cta tct gca tcc cat tgc ttc gac caa cta aac aac tct aaa      336
 Trp Val Leu Ser Ala Ser His Cys Phe Asp Gln Leu Asn Asn Ser Lys
             100                 105                 110

 ttg gag atc att cat ggc act gaa gac ctc agc aca aag ggc ata aag      384
 Leu Glu Ile Ile His Gly Thr Glu Asp Leu Ser Thr Lys Gly Ile Lys
         115                 120                 125

 tat cag aaa gtg gac aag tta ttc ttg cac cca aag ttt gat gac tgg      432
 Tyr Gln Lys Val Asp Lys Leu Phe Leu His Pro Lys Phe Asp Asp Trp
     130                 135                 140

 ctc ctg gac aac gac ata gct ttg ctc ttg ctc aaa tcc cca tta aac      480
 Leu Leu Asp Asn Asp Ile Ala Leu Leu Leu Leu Lys Ser Pro Leu Asn
 145                 150                 155                 160

 ttg agt gtc aac agg ata cct atc tgc act tca gaa atc tct gac ata      528
 Leu Ser Val Asn Arg Ile Pro Ile Cys Thr Ser Glu Ile Ser Asp Ile
                 165                 170                 175

 cag gca tgg agg aac tgc tgg gtg aca gga tgg ggc att act aat act      576
 Gln Ala Trp Arg Asn Cys Trp Val Thr Gly Trp Gly Ile Thr Asn Thr
             180                 185                 190

 agt gaa aaa gga gtc caa ccc aca att ctg cag gca gtc aaa gtg gat      624
 Ser Glu Lys Gly Val Gln Pro Thr Ile Leu Gln Ala Val Lys Val Asp
         195                 200                 205

 ctg tac aga tgg gat tgg tgt ggc tat att ttg tct cta tta acc aag      672
 Leu Tyr Arg Trp Asp Trp Cys Gly Tyr Ile Leu Ser Leu Leu Thr Lys
     210                 215                 220

 aat atg ctg tgt gct ggg act caa gat cct ggg aag gat gcc tgc cag      720
 Asn Met Leu Cys Ala Gly Thr Gln Asp Pro Gly Lys Asp Ala Cys Gln
 225                 230                 235                 240

 ggc gac agt gga gga gct ctc gtt tgc aac aaa aag aga aac aca gcc      768
 Gly Asp Ser Gly Gly Ala Leu Val Cys Asn Lys Lys Arg Asn Thr Ala
                 245                 250                 255

 att tgg tac cag gtg ggc att gtc agc tgg ggc atg ggc tgt ggc aag      816
 Ile Trp Tyr Gln Val Gly Ile Val Ser Trp Gly Met Gly Cys Gly Lys
             260                 265                 270

 aag aat ctg cca gga gta tac acc aag gtg tca cac tat gtg agg tgg      864
 Lys Asn Leu Pro Gly Val Tyr Thr Lys Val Ser His Tyr Val Arg Trp
         275                 280                 285

 atc agc aag cag aca gcg aag gcg ggg agg cct tat atg tat gag cag      912
 Ile Ser Lys Gln Thr Ala Lys Ala Gly Arg Pro Tyr Met Tyr Glu Gln
     290                 295                 300

 aac tct gcg tgc cct ttg gtg ctc tct tgc cgg gct atc ttg gtc cta      960
 Asn Ser Ala Cys Pro Leu Val Leu Ser Cys Arg Ala Ile Leu Val Leu
 305                 310                 315                 320

 tat ttt gga atg ttt ctt cta acc tga tgatt aaacgtgaga actgcaaatg     1012
 Tyr Phe Gly Met Phe Leu Leu Thr 
                 325

 ccaaaaaaaa aaaaaaaagg gggcgcccgg ttctaaagaa tcccttgggg ggccccaaaa   1072

 ttta                                                                1076




      <210> 186
      <211> 2731
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (47)..(847)

      <400> 186
 gtcggcggcg gcggggccgg tcgatggccc gggcggcggc ggcggc   atg cgg ctc      55
                                                      Met Arg Leu
                                                        1

 ctg ttc ctg gcg gtg ctg cgg cca cac acc ggc aac gcg gtc acg gcc      103
 Leu Phe Leu Ala Val Leu Arg Pro His Thr Gly Asn Ala Val Thr Ala
       5                  10                  15

 cag cgc gtt cgg gcc cat cta gag gct gca ggg cac gtg tgc gtt ttg      151
 Gln Arg Val Arg Ala His Leu Glu Ala Ala Gly His Val Cys Val Leu
  20                  25                  30                  35

 aag gat gcc ttt gac ttt gaa agc cga tct gag att gca aac ctc atc      199
 Lys Asp Ala Phe Asp Phe Glu Ser Arg Ser Glu Ile Ala Asn Leu Ile
                  40                  45                  50

 ttg gct gag aac tgc gag gct gcc ctg gct ctt cat ctc tat agg gga      247
 Leu Ala Glu Asn Cys Glu Ala Ala Leu Ala Leu His Leu Tyr Arg Gly
              55                  60                  65

 ggc agg ctt ttg caa ggc cac cga atc cct ttt gga gtc atc ttt ggt      295
 Gly Arg Leu Leu Gln Gly His Arg Ile Pro Phe Gly Val Ile Phe Gly
          70                  75                  80

 gga act gat gta aat gaa gat gcc aac cag gcg gaa aaa aac aca gtc      343
 Gly Thr Asp Val Asn Glu Asp Ala Asn Gln Ala Glu Lys Asn Thr Val
      85                  90                  95

 atg ggc aga gtt ctt gag gaa gcc aga ttt gct gtc gct ttc aca gag      391
 Met Gly Arg Val Leu Glu Glu Ala Arg Phe Ala Val Ala Phe Thr Glu
 100                 105                 110                 115

 tca atg aag gaa atg gca caa gcg cag tgg gtc gat cca gtg ttt aca      439
 Ser Met Lys Glu Met Ala Gln Ala Gln Trp Val Asp Pro Val Phe Thr
                 120                 125                 130

 agg gaa gtg aaa gcc aaa gtg aaa aga gcc gct ggg gta cga ttg att      487
 Arg Glu Val Lys Ala Lys Val Lys Arg Ala Ala Gly Val Arg Leu Ile
             135                 140                 145

 gga gag atg cct caa gaa gat ctg cac gcg gtg gtg aag aat tgc ttc      535
 Gly Glu Met Pro Gln Glu Asp Leu His Ala Val Val Lys Asn Cys Phe
         150                 155                 160

 gcg gtg gtg aat agc tct gtc tct gaa ggc atg tca gct gca att ttg      583
 Ala Val Val Asn Ser Ser Val Ser Glu Gly Met Ser Ala Ala Ile Leu
     165                 170                 175

 gag gca atg gat tta gaa gta ccg gta ttg gcc agg aac atc ccc ggg      631
 Glu Ala Met Asp Leu Glu Val Pro Val Leu Ala Arg Asn Ile Pro Gly
 180                 185                 190                 195

 aat gct gcc gtg gtg aag cat gaa gtc aca ggg cta ctg ttt tcc aat      679
 Asn Ala Ala Val Val Lys His Glu Val Thr Gly Leu Leu Phe Ser Asn
                 200                 205                 210

 cct cag gag ttt gtt cat ctg gca aag aga ctg gtt agt gat cct gca      727
 Pro Gln Glu Phe Val His Leu Ala Lys Arg Leu Val Ser Asp Pro Ala
             215                 220                 225

 tta gaa aag gaa atc gta gtg aac gga agg gaa tac gtg aga atg tat      775
 Leu Glu Lys Glu Ile Val Val Asn Gly Arg Glu Tyr Val Arg Met Tyr
         230                 235                 240

 cat tca tgg cag gtg gaa aga gac acc tac caa cag ctc atc agg aag      823
 His Ser Trp Gln Val Glu Arg Asp Thr Tyr Gln Gln Leu Ile Arg Lys
     245                 250                 255

 ctg gaa gga agc act gaa gat tga gggccccgcc tcatcagaca cctgctctct     877
 Leu Glu Gly Ser Thr Glu Asp 
 260                 265

 gacacacagc tctgggtgca cactcagaga cagagttctg gatcacgtgg gcccagtgca    937

 gttcaaataa aaccagcctc agcggaatcc tagaaaatgt tagtcgtgag tccccagagc    997

 cactgcattc atcccatatc cttctgtgcg ttcagatgct gtcccaggcg tgttcaccag   1057

 ccagtcctga tggaggtgca tgagtgactg ggttgactgg gacagggaaa ggggaactgg   1117

 ttttcaggga atttgggaga gaatttgatt acctgcctta gggctttggt gtggacaata   1177

 gaggcttatt ttcaagcagt catggttcag actcctcccg cctgccttct gaccaacctc   1237

 tccccatcgt tgccagtttg aaaggcaaaa gcaaaacaga cgtgtcagct gagccgagtc   1297

 ctcgcaggat ttttgttgtg atctcaggac tctgacaggc acgtgggtga cccgaggctt   1357

 ctctgaacac tagaaagcgc tgtgagtgag ctcacgcccg gcacagctca cttttcaatg   1417

 gtggaattga aagttgtgct ttttagaaaa gtggccaggc tgcccgcagg ccccgcccac   1477

 ctcttggctg aatttgagtg gaaaaccagg aaggaacaag cgccacgtca cgcatagcct   1537

 gcaaatcgcc cgcgtgaccc tgagatggag gcctgaggct ttgggtccag ggtgggctct   1597

 tccccttccc acatcaggga cccggggatg gatgtcggaa gggtcaccag cctccagcct   1657

 ttggcaggat ggagcttggg tctgcagggc tttgcagcca cacagcgagg tcagtccggg   1717

 gccagccgcg ccatcatggt aatggtggcc tcgccccatc catgtcatcc atgtcacatg   1777

 aggacgtgca gtcttccttg tcctctccta gtggaatttg cctgggagaa cctccactga   1837

 atactgaaat tgttgcatgc ctgtggattc cttacgacaa tggggaacgc ggtgtttccc   1897

 acctcttgtg ggtagaaagc agtctgcttt gaggaggcga gaaggcaaag ccagggcagg   1957

 gcgttgctgt gggaagcgtt cggtgaaagc gggtttcgac gcttaggagg gccgagggag   2017

 aagattccac cagcattgtc cttgcttcaa gttttaggat gtctgaactt tcagctttca   2077

 tgttttcaac catcattttt ttaatggcac aacctacatc ttgtttttaa aagaagtagc   2137

 ctcaaattaa actccttaaa ctctgatgcc ctggggatga gaacaactag cttggatctc   2197

 gtgccgtgta attcaatgtt tcattccgct gcctccatca tgtaatagaa tcgctttcca   2257

 gaaaggcagt taactggaag cagcagaggc tcccagccgt gagaggactg ctcaacaatg   2317

 ccccccatcg ccgccccccc acccctcgca ccccttgtgt tttccctctg aggggcccaa   2377

 gggttatggc tttcatgtct aggtgtgggg acagaggagg gagaggcaga tcctgggccg   2437

 ggagaggatg gcctggtctg aatctggagt aattaatgcc acccaaagaa aaggccctgc   2497

 caggtccaat gttgtcttag atctgatgat gctgctattt acaaaacact gatcgtccga   2557

 aagcttgaat ctgttcctcc tcgaatgacc ctgtagatgc ctgacctcca ccgtacctcc   2617

 acatcactat tcatgtcctt ctaggaaaat gtgcacatgc ctcacgcact atgtgggaag   2677

 ggcgtgtttt taaattaata aagtgtgtca ccattagcca tacgaaaaaa aaaa         2731




      <210> 187
      <211> 442
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (7)..(282)

      <400> 187
 ctgctg   atg aga gag ctg ctg aat aaa act aca ttt tac ctg cct atg      48
          Met Arg Glu Leu Leu Asn Lys Thr Thr Phe Tyr Leu Pro Met
            1               5                  10

 gcc cgc cag gtt ttc ttt cag cta tcg ccc atc cac cca gtc ccc tcg       96
 Ala Arg Gln Val Phe Phe Gln Leu Ser Pro Ile His Pro Val Pro Ser
  15                  20                  25                  30

 aac ctc agc atg ggc tgg aac ctg acc ctg ggc atg aca ttt ggc ata      144
 Asn Leu Ser Met Gly Trp Asn Leu Thr Leu Gly Met Thr Phe Gly Ile
                  35                  40                  45

 gtt gtg gac ctg aca cct gtg ttt gtc cta gtc ctg ttt ctc cct gcc      192
 Val Val Asp Leu Thr Pro Val Phe Val Leu Val Leu Phe Leu Pro Ala
              50                  55                  60

 ttc ctg ttc ctc tcg ctg ccc tca tgg tca ctc cca agg gat cca acc      240
 Phe Leu Phe Leu Ser Leu Pro Ser Trp Ser Leu Pro Arg Asp Pro Thr
          65                  70                  75

 cat gtt aag tat ggg ctg gag gac tgc atg aat gcc tca tga tcttccc      289
 His Val Lys Tyr Gly Leu Glu Asp Cys Met Asn Ala Ser 
      80                  85                  90

 agaggcaaag gcacctactg ccttccaagg tcagtgggag gttgggatca acactgttta    349

 ttatgcttag gacaaaaaag atagggagaa agatgtgcaa ccttacaggt catctttctg    409

 ggatagaaca caatgggtct tctcctgcct cct                                 442




      <210> 188
      <211> 1148
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(1144)

      <400> 188
 ggcggcg  atg tcg ctc gtg ctg cta agc ctg gcc gcg ctg tgc agg agc      49
          Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser
            1               5                  10

 gcc gta ccc cga gag ccg acc gtt caa tgt ggc tct gaa act ggg cca       97
 Ala Val Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro
  15                  20                  25                  30

 tct cca gag tgg atg cta caa cat gat cta atc ccg gga gac ttg agg      145
 Ser Pro Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg
                  35                  40                  45

 gac ctc cga gta gaa cct gtt aca act agt gtt gca aca ggg gac tat      193
 Asp Leu Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr
              50                  55                  60

 tca att ttg atg aat gta agc tgg gta ctc cgg gca gat gcc agc atc      241
 Ser Ile Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile
          65                  70                  75

 cgc ttg ttg aag gcc acc aag att tgt gtg acg ggc aaa agc aac ttc      289
 Arg Leu Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe
      80                  85                  90

 cag tcc tac agc tgt gtg agg tgc aat tac aca gag gcc ttc cag act      337
 Gln Ser Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr
  95                 100                 105                 110

 cag acc aga ccc tct ggt ggt aaa tgg aca ttt tcc tat atc ggc ttc      385
 Gln Thr Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe
                 115                 120                 125

 cct gta gag ctg aac aca gtc tat ttc att ggg gcc cat aat att cct      433
 Pro Val Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro
             130                 135                 140

 aat gca aat atg aat gaa gat ggc cct tcc atg tct gtg aat ttc acc      481
 Asn Ala Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr
         145                 150                 155

 tca cca ggc tgc cta gac cac ata atg aaa tat aaa aaa aag tgt gtc      529
 Ser Pro Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val
     160                 165                 170

 aag gcc gga agc ctg tgg gat ccg aac atc act gct tgt aag aag aat      577
 Lys Ala Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn
 175                 180                 185                 190

 gag gag aca gta gaa gtg aac ttc aca acc act ccc ctg gga aac aga      625
 Glu Glu Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg
                 195                 200                 205

 tac atg gct ctt atc caa cac agc act atc atc ggg ttt tct cag gtg      673
 Tyr Met Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val
             210                 215                 220

 ttt gag cca cac cag aag aaa caa acg cga gct tca gtg gtg att cca      721
 Phe Glu Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro
         225                 230                 235

 gtg act ggg gat agt gaa ggt gct acg gtg cag ctg act cca tat ttt      769
 Val Thr Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe
     240                 245                 250

 cct act tgt ggc agc gac tgc atc cga cat aaa gga aca gtt gtg ctc      817
 Pro Thr Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu
 255                 260                 265                 270

 tgc cca caa aca ggc gtc cct ttc cct ctg gat aac aac aaa agc aag      865
 Cys Pro Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys
                 275                 280                 285

 ccg gga ggc tgg ctg cct ctc ctc ctg ctg tct ctg ctg gtg gcc aca      913
 Pro Gly Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr
             290                 295                 300

 tgg gtg ctg gtg gca ggg atc tat cta atg tgg agg cac gaa agg atc      961
 Trp Val Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile
         305                 310                 315

 aag aag act tcc ttt tct acc acc aca cta ctg ccc ccc att aag gtt     1009
 Lys Lys Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val
     320                 325                 330

 ctt gtg gtt tac cca tct gaa ata tgt ttc cat cac aca att tgt tac     1057
 Leu Val Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr
 335                 340                 345                 350

 ttc act gaa ttt ctt caa aac cat tgc aga agt gag gtc atc ctt gaa     1105
 Phe Thr Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu
                 355                 360                 365

 aag tgg caa aaa aaa aaa aaa aaa aaa att ttt ttt tag gcgc            1148
 Lys Trp Gln Lys Lys Lys Lys Lys Lys Ile Phe Phe 
             370                 375





      <210> 189
      <211> 5334
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (449)..(3895)

      <400> 189
 cagcatccga gggacacagc cctcctgcag tccccagcca caccccctgc gtggcccgcc     60

 ttgtcccaga aacgctgaca tgacggctga gtgccagcct cgggttttcc acgccaggaa    120

 ccctggaggg gaggcggagt gtgccagttt ttagacctgt ccacggcagc gctgagaggg    180

 atggagggga cggggtgctg gtgtgagtcg cttcagggag tccgccccac acgaagccac    240

 ctccccagag gccacgccaa cagcaccgcc cctgctcccc tgctcccctg ctccgaccta    300

 aagtgaaacc tgaaacctgg ctgctttgct gcggtcaccc gggcacccag aggccgacct    360

 tttgggtcag gggagggaag ggagatgcgg atgggagtgg ctctcctgcc gagtccggag    420

 gcagcggctg aggctccagc ccctccct   atg tct gca gcg tcc gtg tgc ctg     472
                                  Met Ser Ala Ala Ser Val Cys Leu
                                    1               5

 gcc ctg cgc ccc tgc ctc aac ggc ggc aag tgc atc gac gac tgc gtc      520
 Ala Leu Arg Pro Cys Leu Asn Gly Gly Lys Cys Ile Asp Asp Cys Val
      10                  15                  20

 acg ggc aac ccc tcc tac acc tgc tcc tgc ctc tcg ggc ttc acg ggg      568
 Thr Gly Asn Pro Ser Tyr Thr Cys Ser Cys Leu Ser Gly Phe Thr Gly
  25                  30                  35                  40

 cgg agg tgc cac ctg gac gtg aac gaa tgt gcc tcc cag ccc tgt cag      616
 Arg Arg Cys His Leu Asp Val Asn Glu Cys Ala Ser Gln Pro Cys Gln
                  45                  50                  55

 aat ggt ggg acc tgt act cac ggc atc aac agt ttc cgc tgc cag tgc      664
 Asn Gly Gly Thr Cys Thr His Gly Ile Asn Ser Phe Arg Cys Gln Cys
              60                  65                  70

 ccg gct ggc ttt ggg gga ccc acc tgt gag aca gcc caa tcc ccc tgt      712
 Pro Ala Gly Phe Gly Gly Pro Thr Cys Glu Thr Ala Gln Ser Pro Cys
          75                  80                  85

 gac acc aaa gag tgt caa cat ggt ggc cag tgc cag gtg gag aac ggc      760
 Asp Thr Lys Glu Cys Gln His Gly Gly Gln Cys Gln Val Glu Asn Gly
      90                  95                 100

 tct gcg gtg tgt gtg tgc cag gcc gga tac acc gga gca gcc tgc gag      808
 Ser Ala Val Cys Val Cys Gln Ala Gly Tyr Thr Gly Ala Ala Cys Glu
 105                 110                 115                 120

 atg gat gtg gac gac tgc agc cct gac ccc tgc ctg aat gga ggc tct      856
 Met Asp Val Asp Asp Cys Ser Pro Asp Pro Cys Leu Asn Gly Gly Ser
                 125                 130                 135

 tgt gtt gac cta gtg ggg aat tac acc tgc ttg tgt gcc gag ccc ttc      904
 Cys Val Asp Leu Val Gly Asn Tyr Thr Cys Leu Cys Ala Glu Pro Phe
             140                 145                 150

 aag gga ctt cgc tgt gag aca gga gac cat cca gtg cca gac gcc tgc      952
 Lys Gly Leu Arg Cys Glu Thr Gly Asp His Pro Val Pro Asp Ala Cys
         155                 160                 165

 ctc tcg gcc cct tgc cac aat ggg ggc acc tgt gtg gat gcg gac cag     1000
 Leu Ser Ala Pro Cys His Asn Gly Gly Thr Cys Val Asp Ala Asp Gln
     170                 175                 180

 ggc tac gtg tgc gag tgc ccc gaa ggc ttc atg ggc ctg gac tgc agg     1048
 Gly Tyr Val Cys Glu Cys Pro Glu Gly Phe Met Gly Leu Asp Cys Arg
 185                 190                 195                 200

 gag aga gtc ccc gat gac tgt gag tgc cgc aac gga ggc aga tgc ctg     1096
 Glu Arg Val Pro Asp Asp Cys Glu Cys Arg Asn Gly Gly Arg Cys Leu
                 205                 210                 215

 ggc gcc aac acc acc ctc tgc cag tgc ccc ctg gga ttc ttt ggg ctt     1144
 Gly Ala Asn Thr Thr Leu Cys Gln Cys Pro Leu Gly Phe Phe Gly Leu
             220                 225                 230

 ctc tgt gaa ttt gaa atc aca gcc atg ccc tgc aac atg aac aca cag     1192
 Leu Cys Glu Phe Glu Ile Thr Ala Met Pro Cys Asn Met Asn Thr Gln
         235                 240                 245

 tgc cca gat ggg ggc tac tgc atg gag cac ggc ggg agc tac ctc tgc     1240
 Cys Pro Asp Gly Gly Tyr Cys Met Glu His Gly Gly Ser Tyr Leu Cys
     250                 255                 260

 gtc tgc cac acc gac cac aat gcc agc cac tcc ctg cca tca ccc tgc     1288
 Val Cys His Thr Asp His Asn Ala Ser His Ser Leu Pro Ser Pro Cys
 265                 270                 275                 280

 gac tcg gac ccc tgc ttc aac gga ggc tcc tgc gat gcc cat gac gac     1336
 Asp Ser Asp Pro Cys Phe Asn Gly Gly Ser Cys Asp Ala His Asp Asp
                 285                 290                 295

 tcc tac acc tgc gag tgc ccg cgc ggg ttc cac ggc aag cac tgc gag     1384
 Ser Tyr Thr Cys Glu Cys Pro Arg Gly Phe His Gly Lys His Cys Glu
             300                 305                 310

 aaa gcc cgg cca cac ctg tgc agc tca ggg ccc tgc cgg aac ggg ggc     1432
 Lys Ala Arg Pro His Leu Cys Ser Ser Gly Pro Cys Arg Asn Gly Gly
         315                 320                 325

 acg tgc aag gag gcg ggc ggc gag tac cac tgc agc tgc ccc tac cgc     1480
 Thr Cys Lys Glu Ala Gly Gly Glu Tyr His Cys Ser Cys Pro Tyr Arg
     330                 335                 340

 ttc act ggg agg cac tgt gag atc ggg aag cca gac tcg tgt gcc tct     1528
 Phe Thr Gly Arg His Cys Glu Ile Gly Lys Pro Asp Ser Cys Ala Ser
 345                 350                 355                 360

 ggc ccc tgt cac aac ggc ggc acc tgc ttc cac tac att ggc aaa tac     1576
 Gly Pro Cys His Asn Gly Gly Thr Cys Phe His Tyr Ile Gly Lys Tyr
                 365                 370                 375

 aag tgt gac tgt ccc cca ggc ttc tcc ggg cgg cac tgc gag ata gcc     1624
 Lys Cys Asp Cys Pro Pro Gly Phe Ser Gly Arg His Cys Glu Ile Ala
             380                 385                 390

 ccc tcc ccc tgc ttc cgg agc ccg tgt gtg aat ggg ggc acc tgc gag     1672
 Pro Ser Pro Cys Phe Arg Ser Pro Cys Val Asn Gly Gly Thr Cys Glu
         395                 400                 405

 gac cgg gac acg gat ttc ttc tgc cac tgc caa gca ggg tac atg gga     1720
 Asp Arg Asp Thr Asp Phe Phe Cys His Cys Gln Ala Gly Tyr Met Gly
     410                 415                 420

 cgc cgg tgc cag gca gag gtg gac tgc ggc ccc ccg gag gag gtg aag     1768
 Arg Arg Cys Gln Ala Glu Val Asp Cys Gly Pro Pro Glu Glu Val Lys
 425                 430                 435                 440

 cac gcc aca ctg cgc ttc aac ggc acg cgg ctg ggc gcg gtg gcc ctg     1816
 His Ala Thr Leu Arg Phe Asn Gly Thr Arg Leu Gly Ala Val Ala Leu
                 445                 450                 455

 tat gca tgt gac cgt ggc tac agc ctg agc gcc ccc agc cgc atc cgg     1864
 Tyr Ala Cys Asp Arg Gly Tyr Ser Leu Ser Ala Pro Ser Arg Ile Arg
             460                 465                 470

 gtc tgc cag cca cac ggt gtc tgg agt gag cct ccc cag tgc ctt gaa     1912
 Val Cys Gln Pro His Gly Val Trp Ser Glu Pro Pro Gln Cys Leu Glu
         475                 480                 485

 atc gat gag tgc cgg tct cag ccg tgc ctg cat ggg ggc tct tgt cag     1960
 Ile Asp Glu Cys Arg Ser Gln Pro Cys Leu His Gly Gly Ser Cys Gln
     490                 495                 500

 gac cgc gtt gct ggg tac ctg tgc ctc tgc agc aca ggc tat gag ggc     2008
 Asp Arg Val Ala Gly Tyr Leu Cys Leu Cys Ser Thr Gly Tyr Glu Gly
 505                 510                 515                 520

 gcc cac tgt gag ctg gag agg gat gag tgc cga gct cac ccg tgc aga     2056
 Ala His Cys Glu Leu Glu Arg Asp Glu Cys Arg Ala His Pro Cys Arg
                 525                 530                 535

 aat gga ggg tcc tgc agg aac ctc cca ggg gcc tat gtc tgc cgg tgc     2104
 Asn Gly Gly Ser Cys Arg Asn Leu Pro Gly Ala Tyr Val Cys Arg Cys
             540                 545                 550

 cct gca ggc ttc gtt gga gtc cac tgt gag aca gag gtg gac gcc tgc     2152
 Pro Ala Gly Phe Val Gly Val His Cys Glu Thr Glu Val Asp Ala Cys
         555                 560                 565

 gac tcc agc ccc tgc cag cat gga ggc cgg tgt gag agc ggc ggc ggg     2200
 Asp Ser Ser Pro Cys Gln His Gly Gly Arg Cys Glu Ser Gly Gly Gly
     570                 575                 580

 gcc tac ctg tgc gtc tgc cca gag agc ttc ttc ggc tac cac tgc gag     2248
 Ala Tyr Leu Cys Val Cys Pro Glu Ser Phe Phe Gly Tyr His Cys Glu
 585                 590                 595                 600

 aca gtg agt gac ccc tgc ttc tcc agc ccc tgt ggg ggc cgt ggc tat     2296
 Thr Val Ser Asp Pro Cys Phe Ser Ser Pro Cys Gly Gly Arg Gly Tyr
                 605                 610                 615

 tgc ctg gcc agc aac ggc tcc cac agc tgc acc tgc aaa gtg ggc tac     2344
 Cys Leu Ala Ser Asn Gly Ser His Ser Cys Thr Cys Lys Val Gly Tyr
             620                 625                 630

 acg ggc gag gac tgc gcc aaa gag ctc ttc cca ccg acg gcc ctc aag     2392
 Thr Gly Glu Asp Cys Ala Lys Glu Leu Phe Pro Pro Thr Ala Leu Lys
         635                 640                 645

 atg gag aga gtg gag gag agt ggg gtc tct atc tcc tgg aac ccg ccc     2440
 Met Glu Arg Val Glu Glu Ser Gly Val Ser Ile Ser Trp Asn Pro Pro
     650                 655                 660

 aat ggt cca gcc gcc agg cag atg ctt gat ggc tac gcg gtc acc tac     2488
 Asn Gly Pro Ala Ala Arg Gln Met Leu Asp Gly Tyr Ala Val Thr Tyr
 665                 670                 675                 680

 gtc tcc tcc gac ggc tcc tac cgc cgc aca gac ttt gtg gac agg acc     2536
 Val Ser Ser Asp Gly Ser Tyr Arg Arg Thr Asp Phe Val Asp Arg Thr
                 685                 690                 695

 cgc tcc tcg cac cag ctc cag gcc ctg gcg gcc ggc agg gcc tac aac     2584
 Arg Ser Ser His Gln Leu Gln Ala Leu Ala Ala Gly Arg Ala Tyr Asn
             700                 705                 710

 atc tcc gtc ttc tca gtg aag cga aac agt aac aac aag aat gac atc     2632
 Ile Ser Val Phe Ser Val Lys Arg Asn Ser Asn Asn Lys Asn Asp Ile
         715                 720                 725

 agc agg cct gcc gtg ctg ctg gcc cgc acg cga ccc cgc cct gtg gaa     2680
 Ser Arg Pro Ala Val Leu Leu Ala Arg Thr Arg Pro Arg Pro Val Glu
     730                 735                 740

 ggc ttc gag gtc acc aat gtg acg gct agc acc atc tca gtg cag tgg     2728
 Gly Phe Glu Val Thr Asn Val Thr Ala Ser Thr Ile Ser Val Gln Trp
 745                 750                 755                 760

 gcc ctg cac agg atc cgc cat gcc acc gtc agt ggg gtc cgt gtg tcc     2776
 Ala Leu His Arg Ile Arg His Ala Thr Val Ser Gly Val Arg Val Ser
                 765                 770                 775

 atc cgc cac cct gag gcc ctc agg gac cag gcc acc gat gtg gac agg     2824
 Ile Arg His Pro Glu Ala Leu Arg Asp Gln Ala Thr Asp Val Asp Arg
             780                 785                 790

 agt gtg gac agg ttc acc ttt agg gcc ctg ctg cct ggg aag agg tac     2872
 Ser Val Asp Arg Phe Thr Phe Arg Ala Leu Leu Pro Gly Lys Arg Tyr
         795                 800                 805

 acc atc cag ctg acc acc ctc agt ggg ctc agg gga gag gag cac ccc     2920
 Thr Ile Gln Leu Thr Thr Leu Ser Gly Leu Arg Gly Glu Glu His Pro
     810                 815                 820

 aca gag agc ctg gcc acc gcg ccg acg cac gtg tgg acc cgg ccc ctg     2968
 Thr Glu Ser Leu Ala Thr Ala Pro Thr His Val Trp Thr Arg Pro Leu
 825                 830                 835                 840

 cct cca gca aac ctg acc gcc gcc cga gtc act gcc acc tct gcc cac     3016
 Pro Pro Ala Asn Leu Thr Ala Ala Arg Val Thr Ala Thr Ser Ala His
                 845                 850                 855

 gtg gtc tgg gat gcc ccg act cca ggc agc ttg ctg gag gct tat gtc     3064
 Val Val Trp Asp Ala Pro Thr Pro Gly Ser Leu Leu Glu Ala Tyr Val
             860                 865                 870

 atc aat gtg acc acc agc cag agc acc aag agc cgc tat gtc ccc aac     3112
 Ile Asn Val Thr Thr Ser Gln Ser Thr Lys Ser Arg Tyr Val Pro Asn
         875                 880                 885

 ggg aag ctg gcg tcc tac acg gtg cgc gac ctg ctg ccg gga cgg cgg     3160
 Gly Lys Leu Ala Ser Tyr Thr Val Arg Asp Leu Leu Pro Gly Arg Arg
     890                 895                 900

 tac cag ctc tct gtg ata gca gtg cag agc acg gag ctc ggg ccg cag     3208
 Tyr Gln Leu Ser Val Ile Ala Val Gln Ser Thr Glu Leu Gly Pro Gln
 905                 910                 915                 920

 cac agc gag ccc gcc cac ctc tac atc atc acc tcc ccc agg gat ggc     3256
 His Ser Glu Pro Ala His Leu Tyr Ile Ile Thr Ser Pro Arg Asp Gly
                 925                 930                 935

 gct gac aga cgc tgg cac cag gga gga cac cac cct cgg gtg ctc aag     3304
 Ala Asp Arg Arg Trp His Gln Gly Gly His His Pro Arg Val Leu Lys
             940                 945                 950

 aac aga ccg ccc ccg gcg cgc ctg ccg gag ctg cgc ctg ctc aat gac     3352
 Asn Arg Pro Pro Pro Ala Arg Leu Pro Glu Leu Arg Leu Leu Asn Asp
         955                 960                 965

 cac agc gcc ccc gag acc ccc acc cag ccc ccc agg ttc tcg gag ctt     3400
 His Ser Ala Pro Glu Thr Pro Thr Gln Pro Pro Arg Phe Ser Glu Leu
     970                 975                 980

 gtg gac ggc aga gga aga gtg agc gcc agg ttc ggt ggc tca ccc agc     3448
 Val Asp Gly Arg Gly Arg Val Ser Ala Arg Phe Gly Gly Ser Pro Ser
 985                 990                 995                1000

 aaa gca gcc acc gtg aga tca caa ccc aca gcc tcg gcg cag ctc gag     3496
 Lys Ala Ala Thr Val Arg Ser Gln Pro Thr Ala Ser Ala Gln Leu Glu
                1005                1010                1015

 aac atg gag gaa gcc ccc aag cgg gtc agc ctg gcc ctc cag ctc cct     3544
 Asn Met Glu Glu Ala Pro Lys Arg Val Ser Leu Ala Leu Gln Leu Pro
            1020                1025                1030

 gaa cac ggc agc aag gac atc gga aac gtc cct ggc aac tgt tca gaa     3592
 Glu His Gly Ser Lys Asp Ile Gly Asn Val Pro Gly Asn Cys Ser Glu
        1035                1040                1045

 aac ccc tgt cag aac gga ggc act tgt gtg ccg ggc gca gac gcc cac     3640
 Asn Pro Cys Gln Asn Gly Gly Thr Cys Val Pro Gly Ala Asp Ala His
    1050                1055                1060

 agc tgt gac tgc ggg cca ggg ttc aaa ggc aga cgc tgc gag ctc gcc     3688
 Ser Cys Asp Cys Gly Pro Gly Phe Lys Gly Arg Arg Cys Glu Leu Ala
1065                1070                1075                1080

 tgt ata aag gtg tcc cgc ccc tgc aca agg ctg ttc tcc gag aca aag     3736
 Cys Ile Lys Val Ser Arg Pro Cys Thr Arg Leu Phe Ser Glu Thr Lys
                1085                1090                1095

 gcc ttt cca gtc tgg gag gga ggc gtc tgt cac cac gtg tat aaa aga     3784
 Ala Phe Pro Val Trp Glu Gly Gly Val Cys His His Val Tyr Lys Arg
            1100                1105                1110

 gtc tac cga gtt cac caa gac atc tgc ttc aaa gag agc tgt gaa agc     3832
 Val Tyr Arg Val His Gln Asp Ile Cys Phe Lys Glu Ser Cys Glu Ser
        1115                1120                1125

 aca agc ctc aag aag acc cca aac agg aaa caa agt aag agt cag aca     3880
 Thr Ser Leu Lys Lys Thr Pro Asn Arg Lys Gln Ser Lys Ser Gln Thr
    1130                1135                1140

 ctg gag aaa tct taa ggatttaaga cgttcttgtt acactccacc aacctcacga     3935
 Leu Glu Lys Ser 
1145

 gtttctaaca cccaggaaga tgaggtctaa aaactggatg aaaaaggaca ccctgagaaa   3995

 aggtcctagc tggagtcagt cccctctgtg acctctctcc tcaggcctct agaggacaga   4055

 tggccaggcc tgtgcacaca ccagcccacc ctgagagacc cctctgggac caaccacctg   4115

 tgagtcctgc gatgcgttta agcagcctgt gccctcaccc aagctgcagt tcctgaaggt   4175

 gtagtctgtg tctctgcgga tgagatgaca gctcgccatt ccccggaatc agtgaggctg   4235

 tcagtcagcc acgcttctgc agtatgcaga aacctgttct tagactccaa agccagagaa   4295

 agaattctcc cttcgaggcc caacaaattg agaaggaact gtgatggacc acttccaaaa   4355

 cagagacggg ggcaggggct gaagggcaga gaccaggtga tgtcagaagg aaagccgggt   4415

 tgcagacaca gccgcccctg ctctggtcct ccagcgtgtt tatgacgctc gtgcaggtcg   4475

 acgagccatc ctatggacta gttaacacta aggtggagtt cagacttttt tagacaacgg   4535

 cgcgactggc agcctttctc tatcaagggt cagacggtaa acgttttcag ctttgcagac   4595

 cagaggtccc tgtggctaca gtagcgcaga cacagccaca ggcatgtcat tgaatggctg   4655

 cggctatgtt ccaataaaaa cttatttaca ataacaggtg gtggccaaat tggcccatgg   4715

 gccttatttg gtgaaccctg ttctatgaga tcacctaggc ttcagcctta aacagtggaa   4775

 gccatcccct gaatgacaag tcacaagggt atcaaagaaa gacccctgaa ttttcatgga   4835

 aaaagctatt cagacccctg cttggaaagc taaggcacac tgccacgaag cagcaaggac   4895

 gccttacaag tctcagtgca acagagatgg acacctgggc tgggctggac aatgtttaag   4955

 gttcctttta gtccatgact caagtgatac tgttttaggc tatcaggtag taaacacgat   5015

 cttagacatc cccatctttg taagcagaac agtacggcac ttcaccacat ctgcttccca   5075

 ccatgcttct aagcagctgt cttccccctg ctaatgttac aaccaaagca gccaccccac   5135

 ctcctctcgt gttgagcctc acgaccgctg acccagctgg aaagccagcg ccctgccgcg   5195

 tcaccctgac tctgctcaga gccagcattc cagccacaaa gagggcctcc ttcctttcct   5255

 ctttcataaa aatgtttttt gaagagttag agtatatttt aggcttttta tctttattaa   5315

 aatttcatgt gcatgtgta                                                5334




      <210> 190
      <211> 1334
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (697)..(1173)

      <400> 190
 gtgaagagat agtggggatg tgggtgtgtt gtgctggttt tgttcggtgt tttgttgttg     60

 ggtgtgtggc gtgcgtgggg tgatgtgttg gtgggtgtgt cgtgataggg agcttggtct    120

 ggagagaggg ccatggtgtg atgaggaaaa tgttgagtcg aaggtaccaa aggcgagact    180

 gtatcgaaat tggggaagag caatagggag atgtgatgga caattgtgga gttgatggaa    240

 attggcgagc ggggtattgg agtccagtga atgggaatgg ggcgatggaa tgaggggatg    300

 gattgaggga atggatggaa tgggggatga gggatggggc cgcagcatcc ccctctccgg    360

 tacccagtgt aggtcacaat aatttaaaga cactatagac atttcgacgc tatataacaa    420

 cataagttaa ccaggttcct tgcagaggct gccgggccta tggactcagg tgtgttctgg    480

 gacttgggga aggtaagggg atggggccag gctgagggtg gggcattcac ggtggcccgg    540

 agactcagag cgtccaggca tggttagagg cacatgggct ggaccacagg gccagagccc    600

 aggagggacc cacttgcccc aggctgagcc caggcccttg gcttgtcggc tgctcaagaa    660

 cacattccta cgggcttcca agagaacaca ccctaa  atg ggg gcc agg ccg tgg     714
                                          Met Gly Ala Arg Pro Trp
                                            1               5

 gca gtg ggg gtg cac cag gag cca gct gca gac cat cct ctc tgg cct      762
 Ala Val Gly Val His Gln Glu Pro Ala Ala Asp His Pro Leu Trp Pro
              10                  15                  20

 cgg aca agt tcc tcc ctc tgt cac tca tgc tcc tca gag aca ggg gtg      810
 Arg Thr Ser Ser Ser Leu Cys His Ser Cys Ser Ser Glu Thr Gly Val
          25                  30                  35

 gga gca tcc aga aag gac atg tcc agc tct gga tcc aga ttt tct cag      858
 Gly Ala Ser Arg Lys Asp Met Ser Ser Ser Gly Ser Arg Phe Ser Gln
      40                  45                  50

 cac tgg ggt cag ggt aaa agg acc agg aca ggg cta ggc gaa gcc tca      906
 His Trp Gly Gln Gly Lys Arg Thr Arg Thr Gly Leu Gly Glu Ala Ser
  55                  60                  65                  70

 aag gca ccg agg gga gtg cag gcc cca atg agg ctg tca ggg ggt gga      954
 Lys Ala Pro Arg Gly Val Gln Ala Pro Met Arg Leu Ser Gly Gly Gly
                  75                  80                  85

 ggg agc agc caa gtg cct caa ggc atg gga gct acc tac tgc cac ccc     1002
 Gly Ser Ser Gln Val Pro Gln Gly Met Gly Ala Thr Tyr Cys His Pro
              90                  95                 100

 ggg cat cct gat gtg ttc tcc cag gtc cag agc ccc agg ctg ggc agg     1050
 Gly His Pro Asp Val Phe Ser Gln Val Gln Ser Pro Arg Leu Gly Arg
         105                 110                 115

 aga aag gtg gaa gcc tcc agt cac agc tgc agg gtc tct ggt agg tcc     1098
 Arg Lys Val Glu Ala Ser Ser His Ser Cys Arg Val Ser Gly Arg Ser
     120                 125                 130

 ttg tgc cac tct ggg cct cag agt tcc cat ctg tca agt ggg aca aac     1146
 Leu Cys His Ser Gly Pro Gln Ser Ser His Leu Ser Ser Gly Thr Asn
 135                 140                 145                 150

 atc cct gac cac tca cca cct gcc tga ccccc gcggcagcac tgtcccaggg     1198
 Ile Pro Asp His Ser Pro Pro Ala 
                 155

 gtcaggctgg ctccaggggg aagggggtct ctgtaaactg gaggtgccag gccgggaggg   1258

 tgacaggatg agggagggaa cgaaggactc ctggaacctg acgtgggtga tattttgatt   1318

 tgcttgatat tatttt                                                   1334




      <210> 191
      <211> 2056
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (350)..(1876)

      <400> 191
 acggctgcga gaagacgaca gaaggggggg tagagtgttt gggtagcatt aaaacagtga     60

 gtgccctgtg agaagcacag tgcctgggtg cagcactttg catcagctct gattttgaaa    120

 tcagacacag aaggctttga agccggccag taaggggttg tcaggcagtt gactaatgct    180

 cttgatttga atcggaggct gctgtgaaaa gggatgcagc ttctgctagc cactgtgaac    240

 ttctgaatct cactagggtt gggtctgctt tggggcactc agataacccc agtatttcca    300

 aaccagcttt cccttttgct tcaggacata tcttacccaa gcctgcact    atg gag     355
                                                          Met Glu
                                                            1

 aag tgg gac ggt aat gag ggc acc tca gct ttt cac atg cct gag tgg      403
 Lys Trp Asp Gly Asn Glu Gly Thr Ser Ala Phe His Met Pro Glu Trp
           5                  10                  15

 atg atc cag ttt gct gac cag aag caa gaa ttc aac aaa cgt ccc acc      451
 Met Ile Gln Phe Ala Asp Gln Lys Gln Glu Phe Asn Lys Arg Pro Thr
      20                  25                  30

 aaa att gga cgt cgc tct ttg tct cgt tcc att tct cag tca tct act      499
 Lys Ile Gly Arg Arg Ser Leu Ser Arg Ser Ile Ser Gln Ser Ser Thr
  35                  40                  45                  50

 gac agc tac agc tca gcg gct tca tat aca gat agc tct gat gat gag      547
 Asp Ser Tyr Ser Ser Ala Ala Ser Tyr Thr Asp Ser Ser Asp Asp Glu
                  55                  60                  65

 aca tcg ccc agg gac aag cag caa aag aac tct aag gga agc agt gac      595
 Thr Ser Pro Arg Asp Lys Gln Gln Lys Asn Ser Lys Gly Ser Ser Asp
              70                  75                  80

 ttc tgt gtt aag aac atc aaa cag gca gag ttt gga cga aga gaa att      643
 Phe Cys Val Lys Asn Ile Lys Gln Ala Glu Phe Gly Arg Arg Glu Ile
          85                  90                  95

 gaa att gct gaa caa gaa atg cct gca ttg atg gct ttg agg aag aga      691
 Glu Ile Ala Glu Gln Glu Met Pro Ala Leu Met Ala Leu Arg Lys Arg
     100                 105                 110

 gct caa gga gaa aag cct ttg gct gga gcc aaa atc gtg ggt tgc aca      739
 Ala Gln Gly Glu Lys Pro Leu Ala Gly Ala Lys Ile Val Gly Cys Thr
 115                 120                 125                 130

 cac atc act gct cag act gct gtg ctt atg gaa act ctg ggt gct ctg      787
 His Ile Thr Ala Gln Thr Ala Val Leu Met Glu Thr Leu Gly Ala Leu
                 135                 140                 145

 ggg gcc cag tgc cga tgg gct gcc tgc aac atc tat tcc act ctc aat      835
 Gly Ala Gln Cys Arg Trp Ala Ala Cys Asn Ile Tyr Ser Thr Leu Asn
             150                 155                 160

 gaa gtg gct gct gct cta gca gaa agt gga ttt cct gtt ttt gcc tgg      883
 Glu Val Ala Ala Ala Leu Ala Glu Ser Gly Phe Pro Val Phe Ala Trp
         165                 170                 175

 aag gga gag tca gaa gat gac ttc tgg tgg tgt atc gat aga tgt gtg      931
 Lys Gly Glu Ser Glu Asp Asp Phe Trp Trp Cys Ile Asp Arg Cys Val
     180                 185                 190

 aat gtg gag ggc tgg cag cca aac atg atc ttg gat gat gga ggg gat      979
 Asn Val Glu Gly Trp Gln Pro Asn Met Ile Leu Asp Asp Gly Gly Asp
 195                 200                 205                 210

 ctt acc cac tgg att tat aaa aag tat ccc aac atg ttt aag aaa atc     1027
 Leu Thr His Trp Ile Tyr Lys Lys Tyr Pro Asn Met Phe Lys Lys Ile
                 215                 220                 225

 aag ggc ata gta gag gag agt gtt act gga gtt cac agg ctg tac caa     1075
 Lys Gly Ile Val Glu Glu Ser Val Thr Gly Val His Arg Leu Tyr Gln
             230                 235                 240

 ctg tcc aaa gct ggg aag ctg tgt gtt cca gcc atg aat gtc aat gac     1123
 Leu Ser Lys Ala Gly Lys Leu Cys Val Pro Ala Met Asn Val Asn Asp
         245                 250                 255

 tca gtc acc aaa cag aaa ttt gac aac ctc tac tgt tgc cgt gaa tca     1171
 Ser Val Thr Lys Gln Lys Phe Asp Asn Leu Tyr Cys Cys Arg Glu Ser
     260                 265                 270

 att ctt gat gga ctt aaa agg aca aca gac atg atg ttt ggt gga aag     1219
 Ile Leu Asp Gly Leu Lys Arg Thr Thr Asp Met Met Phe Gly Gly Lys
 275                 280                 285                 290

 caa gtg gta gtc tgt ggc tat gga gag gtg ggg aaa ggg tgc tgt gct     1267
 Gln Val Val Val Cys Gly Tyr Gly Glu Val Gly Lys Gly Cys Cys Ala
                 295                 300                 305

 gcc ctg aaa gcc atg ggc tcc att gtg tat gta act gaa att gac ccc     1315
 Ala Leu Lys Ala Met Gly Ser Ile Val Tyr Val Thr Glu Ile Asp Pro
             310                 315                 320

 atc tgt gcc ctg caa gcc tgt atg gat gga ttt cga ctg gtg aaa tta     1363
 Ile Cys Ala Leu Gln Ala Cys Met Asp Gly Phe Arg Leu Val Lys Leu
         325                 330                 335

 aat gag gtc atc cga caa gtg gac att gtt att acc tgt aca ggt aac     1411
 Asn Glu Val Ile Arg Gln Val Asp Ile Val Ile Thr Cys Thr Gly Asn
     340                 345                 350

 aag aat gtg gta acc aga gag cac ttg gac cgt atg aag aat agc tgc     1459
 Lys Asn Val Val Thr Arg Glu His Leu Asp Arg Met Lys Asn Ser Cys
 355                 360                 365                 370

 atc gtt tgt aac atg gga cat tcc aac aca gag att gac gtg gcg agt     1507
 Ile Val Cys Asn Met Gly His Ser Asn Thr Glu Ile Asp Val Ala Ser
                 375                 380                 385

 ctg cgg aca cca gaa ctg acc tgg gag cga gtg aga tct caa gtt gac     1555
 Leu Arg Thr Pro Glu Leu Thr Trp Glu Arg Val Arg Ser Gln Val Asp
             390                 395                 400

 cat gtg ata tgg cct gat ggc aag agg ata gta ctg ctg gca gag ggc     1603
 His Val Ile Trp Pro Asp Gly Lys Arg Ile Val Leu Leu Ala Glu Gly
         405                 410                 415

 cgc ctg ctg aac ctt agc tgc tcc aca gtg cct aca ttt gtg ctc tca     1651
 Arg Leu Leu Asn Leu Ser Cys Ser Thr Val Pro Thr Phe Val Leu Ser
     420                 425                 430

 atc act gct act act cag gct ctt gcc ttg ata gag ctt tac aat gct     1699
 Ile Thr Ala Thr Thr Gln Ala Leu Ala Leu Ile Glu Leu Tyr Asn Ala
 435                 440                 445                 450

 cct gag ggt cgc tat aag cag gat gtc tac ctg ttg ccc aag aag atg     1747
 Pro Glu Gly Arg Tyr Lys Gln Asp Val Tyr Leu Leu Pro Lys Lys Met
                 455                 460                 465

 gat gag tat gtg gcc agc cta cac ctg cct acc ttt gat gcc cac ttg     1795
 Asp Glu Tyr Val Ala Ser Leu His Leu Pro Thr Phe Asp Ala His Leu
             470                 475                 480

 aca gag ctg aca gat gaa cag gcc aag tat ctg gga ctc aac aag aat     1843
 Thr Glu Leu Thr Asp Glu Gln Ala Lys Tyr Leu Gly Leu Asn Lys Asn
         485                 490                 495

 ggg ccc ttc aag cct aat tac tac agg tat taa gttcctgt aactcaaacc     1894
 Gly Pro Phe Lys Pro Asn Tyr Tyr Arg Tyr 
     500                 505

 agaattttta aggaatagaa ctccaagcct tttctccact actatacaag aaagaattca   1954

 gcaagctgct tctccaatca aagctgcctg ccgtgctcac cctgtgtgtt aggttattta   2014

 tttattaaaa tcaagaatcc tgtgcctgca aaaaaaaaaa aa                      2056




      <210> 192
      <211> 1149
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (252)..(521)

      <400> 192
 ttcgctgacg acgatttacg attcttgaag aaaccgtctc tactaaaaat gcagaaacct     60

 agccgggcgt ggtggcacgt gcctgtggtc ccagctgctc gggaggctga ggcaagagga    120

 tggcttgaac tcgggaggca gaggttgtgg tgagccgaga tcacagcact gcactccagc    180

 ctgggtgaca agagcaagac tccgtctcaa aataaataaa taaaaataaa aaataaacat    240

 gatgatcaca g atg cag tca cat ttt ctg agt tct tgt ctc tct gcc agt     290
              Met Gln Ser His Phe Leu Ser Ser Cys Leu Ser Ala Ser
                1               5                  10

 gcc acc cag ata gcc tca caa aac ttt gac cca gcc act gtt agt gtc      338
 Ala Thr Gln Ile Ala Ser Gln Asn Phe Asp Pro Ala Thr Val Ser Val
      15                  20                  25

 gcc acc gcc cat aaa gga gct gag ccc agc agg ggc act gcc tgg ggc      386
 Ala Thr Ala His Lys Gly Ala Glu Pro Ser Arg Gly Thr Ala Trp Gly
  30                  35                  40                  45

 cct gta gcc aaa agg cta cag cag gag ctg atg acc ctc atg atg cct      434
 Pro Val Ala Lys Arg Leu Gln Gln Glu Leu Met Thr Leu Met Met Pro
                  50                  55                  60

 ggt gac aaa aga att tct gcc tac cct gaa agc ctt atc aaa tgg aca      482
 Gly Asp Lys Arg Ile Ser Ala Tyr Pro Glu Ser Leu Ile Lys Trp Thr
              65                  70                  75

 cca tcc atg aag cag ctg gca cag tgt atg aag atc tga ggtataagct       531
 Pro Ser Met Lys Gln Leu Ala Gln Cys Met Lys Ile 
          80                  85

 cttgctggag ttcctcaatg actacccacc tttacgatgc acccacagtg aagttcctca    591

 caccctgcta ccaccctaac gtggacaccc agggtaacat atgcctggac atcctgaagg    651

 agaagtggtc tgccccgtat gatatcagga ccatcctgct ctctatccag tgcctgctag    711

 gacaactcaa cattgatagc cctttgaaca cacatgctac caagctctgg gaaaacccca    771

 tagctttaag aagtacctgc aagggtcagg cgcagtggct cacacctgta atcccagcac    831

 tttgggaggc cgaggtgggt ggatggatca cctgacgtag agagtccaag gcctgacaaa    891

 catggagaaa tgtcatccct atttaaaaaa ataaaaaaat tagccaagtg tggtggcgca    951

 tgcctgtaat cccagctact cgggaggctg aggcaggaga atcacttgaa cctgggaggt   1011

 ggaggttgca gtgagccgag atctcgctat tgcactccag cctgggcaac aagagtgaaa   1071

 ctctgcctca aaagaaagtt atataatata aaaatataaa taaggaagta cctgcaagaa   1131

 agctactcaa agtaggtc                                                 1149




      <210> 193
      <211> 2921
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (38)..(2542)

      <400> 193
 ggtcgacgat ttcgtagccc cttaccttcc tgacccc atg aag cac aca ctg gct      55
                                          Met Lys His Thr Leu Ala
                                            1               5

 ctg ctg gct ccc ctg ctg ggc ctg ggc ctg ggg ctg gcc ctg agt cag      103
 Leu Leu Ala Pro Leu Leu Gly Leu Gly Leu Gly Leu Ala Leu Ser Gln
              10                  15                  20

 ctg gct gca ggg gcc aca gac tgc aag ttc ctt ggc ccg gca gag cac      151
 Leu Ala Ala Gly Ala Thr Asp Cys Lys Phe Leu Gly Pro Ala Glu His
          25                  30                  35

 ctg aca ttc acc cca gca gcc agg gcc cgg tgg ctg gcc cct cga gtt      199
 Leu Thr Phe Thr Pro Ala Ala Arg Ala Arg Trp Leu Ala Pro Arg Val
      40                  45                  50

 cgt gcg cca gga ctc ctg gac tcc ctc tat ggc acc gtg cgc cgc ttc      247
 Arg Ala Pro Gly Leu Leu Asp Ser Leu Tyr Gly Thr Val Arg Arg Phe
  55                  60                  65                  70

 ctc tcg gtg gtg cag ctc aat cct ttc cct tca gag ttg gta aag gcc      295
 Leu Ser Val Val Gln Leu Asn Pro Phe Pro Ser Glu Leu Val Lys Ala
                  75                  80                  85

 cta ctg aat gag ctg gcc tcc gtg aag gtg aat gag gtg gtg cgg tac      343
 Leu Leu Asn Glu Leu Ala Ser Val Lys Val Asn Glu Val Val Arg Tyr
              90                  95                 100

 gag gcg ggc tac gtg gta tgc gct gtg atc gcg ggc ctc tac ctg ctg      391
 Glu Ala Gly Tyr Val Val Cys Ala Val Ile Ala Gly Leu Tyr Leu Leu
         105                 110                 115

 ctg gtg ccc act gcc ggg ctt tgc ttc tgc tgc tgc cgc tgc cac cgg      439
 Leu Val Pro Thr Ala Gly Leu Cys Phe Cys Cys Cys Arg Cys His Arg
     120                 125                 130

 cgc tgc ggg gga cga gtg aag aca gag cac aag gcg ctg gcc tgt gag      487
 Arg Cys Gly Gly Arg Val Lys Thr Glu His Lys Ala Leu Ala Cys Glu
 135                 140                 145                 150

 cgc gcg gcc ctc atg gtc ttc ctg ctg ctg acc acc ctc ttg ctg ctg      535
 Arg Ala Ala Leu Met Val Phe Leu Leu Leu Thr Thr Leu Leu Leu Leu
                 155                 160                 165

 att ggt gtg gtc tgt gcc ttt gtc acc aac cag cgc acg cat gaa cag      583
 Ile Gly Val Val Cys Ala Phe Val Thr Asn Gln Arg Thr His Glu Gln
             170                 175                 180

 atg ggc ccc agc atc gag gcc atg cct gag acc ctg ctc agc ctc tgg      631
 Met Gly Pro Ser Ile Glu Ala Met Pro Glu Thr Leu Leu Ser Leu Trp
         185                 190                 195

 ggc ctg gtc tct gat gtc ccc caa gag ctg cag gcc gtg gca cag caa      679
 Gly Leu Val Ser Asp Val Pro Gln Glu Leu Gln Ala Val Ala Gln Gln
     200                 205                 210

 ttc tcc ctg ccc cag gag caa gtc tca gag gag ctg gat ggt gtt ggt      727
 Phe Ser Leu Pro Gln Glu Gln Val Ser Glu Glu Leu Asp Gly Val Gly
 215                 220                 225                 230

 gtg agc att ggg agc gcg atc cac act cag ctc agg agc tcc gtg tac      775
 Val Ser Ile Gly Ser Ala Ile His Thr Gln Leu Arg Ser Ser Val Tyr
                 235                 240                 245

 ccc ttg ctg gcg gcc gtg ggc agt ttg ggc cag gtc ctg cag gtc tcc      823
 Pro Leu Leu Ala Ala Val Gly Ser Leu Gly Gln Val Leu Gln Val Ser
             250                 255                 260

 gtg cac cac ctg caa acc ttg aat gct aca gtg gta gag ctg cag gcc      871
 Val His His Leu Gln Thr Leu Asn Ala Thr Val Val Glu Leu Gln Ala
         265                 270                 275

 ggg cag cag gac ctg gag cca gcc atc cgg gaa cac cgg gac cgc ctc      919
 Gly Gln Gln Asp Leu Glu Pro Ala Ile Arg Glu His Arg Asp Arg Leu
     280                 285                 290

 ctt gag ctg ctg cag gag gcc agg tgc cag gga gat tgt gca ggg gcc      967
 Leu Glu Leu Leu Gln Glu Ala Arg Cys Gln Gly Asp Cys Ala Gly Ala
 295                 300                 305                 310

 ctg agc tgg gcc cgc acc ctg gag ctg ggt gct gac ttc agc cag gtg     1015
 Leu Ser Trp Ala Arg Thr Leu Glu Leu Gly Ala Asp Phe Ser Gln Val
                 315                 320                 325

 ccc tct gtg gac cat gtc ctg cac cag cta aaa ggt gtc ccc gag gcc     1063
 Pro Ser Val Asp His Val Leu His Gln Leu Lys Gly Val Pro Glu Ala
             330                 335                 340

 aac ttc tcc agc atg gtc cag gag gag aac agc acc ttc aac gcc ctt     1111
 Asn Phe Ser Ser Met Val Gln Glu Glu Asn Ser Thr Phe Asn Ala Leu
         345                 350                 355

 cca gcc ctg gct gcc atg cag aca tcc agc gtg gtg caa gag ctg aag     1159
 Pro Ala Leu Ala Ala Met Gln Thr Ser Ser Val Val Gln Glu Leu Lys
     360                 365                 370

 aag gca gtg gcc cag cag ccg gaa ggg gtg agg aca ctg gct gaa ggg     1207
 Lys Ala Val Ala Gln Gln Pro Glu Gly Val Arg Thr Leu Ala Glu Gly
 375                 380                 385                 390

 ttc ccg ggc ttg gag gca gct tcc cgc tgg gcc cag gca ctg cag gag     1255
 Phe Pro Gly Leu Glu Ala Ala Ser Arg Trp Ala Gln Ala Leu Gln Glu
                 395                 400                 405

 gtg gag gag agc agc cgc ccc tac ctg cag gag gtg cag aga tac gag     1303
 Val Glu Glu Ser Ser Arg Pro Tyr Leu Gln Glu Val Gln Arg Tyr Glu
             410                 415                 420

 acc tac agg tgg atc gtg ggc tgc gtg ctg tgc tcc gtg gtc cta ttc     1351
 Thr Tyr Arg Trp Ile Val Gly Cys Val Leu Cys Ser Val Val Leu Phe
         425                 430                 435

 gtg gtg ctc tgc aac ctg ctg ggc ctc aat ctg ggc atc tgg ggc ctg     1399
 Val Val Leu Cys Asn Leu Leu Gly Leu Asn Leu Gly Ile Trp Gly Leu
     440                 445                 450

 tct gcc agg gac gac ccc agc cac cca gaa gcc aag ggc gag gct gga     1447
 Ser Ala Arg Asp Asp Pro Ser His Pro Glu Ala Lys Gly Glu Ala Gly
 455                 460                 465                 470

 gcc cgc ttc ctc atg gca ggt gtg ggc ctc agc ttc ctc ttt gct gca     1495
 Ala Arg Phe Leu Met Ala Gly Val Gly Leu Ser Phe Leu Phe Ala Ala
                 475                 480                 485

 ccc ctc atc ctc ctg gtg ttc gcc acc ttc ctg gtg ggt ggc aac gtg     1543
 Pro Leu Ile Leu Leu Val Phe Ala Thr Phe Leu Val Gly Gly Asn Val
             490                 495                 500

 cag acg ctg gtg tgc cag agc tgg gag aac agc gag ctc ttt gag ttt     1591
 Gln Thr Leu Val Cys Gln Ser Trp Glu Asn Ser Glu Leu Phe Glu Phe
         505                 510                 515

 gca gac acc cca ggg aac ctg ccc ccg tcc atg aac ctg tcg caa ctt     1639
 Ala Asp Thr Pro Gly Asn Leu Pro Pro Ser Met Asn Leu Ser Gln Leu
     520                 525                 530

 ctt ggc ctg agg aag aac atc agc atc cac caa gcc tat cag cag tgc     1687
 Leu Gly Leu Arg Lys Asn Ile Ser Ile His Gln Ala Tyr Gln Gln Cys
 535                 540                 545                 550

 aag gaa ggg gca gcg ctc tgg aca gtc ctg cag ctc aac gac tcc tac     1735
 Lys Glu Gly Ala Ala Leu Trp Thr Val Leu Gln Leu Asn Asp Ser Tyr
                 555                 560                 565

 gac ctg gag gag cac ctg gat atc aac cag tat acc aac aag cta cgg     1783
 Asp Leu Glu Glu His Leu Asp Ile Asn Gln Tyr Thr Asn Lys Leu Arg
             570                 575                 580

 cag gag ttg cag agc ctg aaa gta gac aca cag agc ctg gac ctg ctg     1831
 Gln Glu Leu Gln Ser Leu Lys Val Asp Thr Gln Ser Leu Asp Leu Leu
         585                 590                 595

 agc tca gcc gcc cgc cgg gac ctg gag gcc ctg cag agc agt ggg ctt     1879
 Ser Ser Ala Ala Arg Arg Asp Leu Glu Ala Leu Gln Ser Ser Gly Leu
     600                 605                 610

 cag cgc atc cac tac ccc gac ttc ctc gtt cag atc cag agg ccc gtg     1927
 Gln Arg Ile His Tyr Pro Asp Phe Leu Val Gln Ile Gln Arg Pro Val
 615                 620                 625                 630

 gtg aag acc agc atg gag cag ctg gcc cag gag ctg caa gga ctg gcc     1975
 Val Lys Thr Ser Met Glu Gln Leu Ala Gln Glu Leu Gln Gly Leu Ala
                 635                 640                 645

 cag gcc caa gac aat tct gtg ctg ggg cag cgg ctg cag gag gag gcc     2023
 Gln Ala Gln Asp Asn Ser Val Leu Gly Gln Arg Leu Gln Glu Glu Ala
             650                 655                 660

 caa gga ctc aga aac ctt cac cag gag aag gtc gtc ccc cag cag agc     2071
 Gln Gly Leu Arg Asn Leu His Gln Glu Lys Val Val Pro Gln Gln Ser
         665                 670                 675

 ctt gtg gca aag ctc aac ctc agc gtc agg gcc ctg gag tcc tct gcc     2119
 Leu Val Ala Lys Leu Asn Leu Ser Val Arg Ala Leu Glu Ser Ser Ala
     680                 685                 690

 ccg aat ctc cag ctg gag acc tca gat gtc cta gcc aat gtc acc tac     2167
 Pro Asn Leu Gln Leu Glu Thr Ser Asp Val Leu Ala Asn Val Thr Tyr
 695                 700                 705                 710

 ctg aaa gga gag ctg cct gcc tgg gca gcc agg atc ctg agg aat gtg     2215
 Leu Lys Gly Glu Leu Pro Ala Trp Ala Ala Arg Ile Leu Arg Asn Val
                 715                 720                 725

 agt gag tgt ttc ctg gcc cgg gag atg ggc tac ttc tcc cag tac gtg     2263
 Ser Glu Cys Phe Leu Ala Arg Glu Met Gly Tyr Phe Ser Gln Tyr Val
             730                 735                 740

 gcc tgg gtg aga gag gag gtg act cag cgc att gcc acc tgc cag ccc     2311
 Ala Trp Val Arg Glu Glu Val Thr Gln Arg Ile Ala Thr Cys Gln Pro
         745                 750                 755

 ctc tcc gga gcc ctg gac aac agc cgt gtg atc ctg tgt gac atg atg     2359
 Leu Ser Gly Ala Leu Asp Asn Ser Arg Val Ile Leu Cys Asp Met Met
     760                 765                 770

 gct gac ccc tgg aat gcc ttc tgg ttc tgc ctg gca tgg tgc acc ttc     2407
 Ala Asp Pro Trp Asn Ala Phe Trp Phe Cys Leu Ala Trp Cys Thr Phe
 775                 780                 785                 790

 ttc ctg atc ccc agc atc atc ttt gcc gtc aag acc tcc aaa tac ttc     2455
 Phe Leu Ile Pro Ser Ile Ile Phe Ala Val Lys Thr Ser Lys Tyr Phe
                 795                 800                 805

 cgt cct atc cgg aaa cgc ctc agc tcc acc agc tct gag gag act cag     2503
 Arg Pro Ile Arg Lys Arg Leu Ser Ser Thr Ser Ser Glu Glu Thr Gln
             810                 815                 820

 ctc ttc cac atc ccc cgg gtt acc tcc ctg aag ctg tag ggccttgtgg      2552
 Leu Phe His Ile Pro Arg Val Thr Ser Leu Lys Leu 
         825                 830

 gtgggttttc cccaactcgc ttaattgctc cctgccaggg attaagggag tggggtgggg   2612

 aggggctggg gtctggggtt tccagggcct aggagggcag gaaggcttgg ggacatggtg   2672

 gagtctgggt attgggtgtg gcccatccag cagtggggct gacagccctg ttctcccctc   2732

 cctccccttc acccgtttcc ttcttaatcc ctgacagggt gaggtgaccc tgaggctgcc   2792

 tgtcctcccc tttgatttag cctgggccac aggacttcgg tagctcttgc cccagagccc   2852

 aggctggcat ccaggcctgg actgtcccca gttccggctt acctggcccc accttgcctg   2912

 ctcctttcc                                                           2921




      <210> 194
      <211> 1824
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(1206)

      <400> 194
 tgatatttga agaagtgttt tcatctatcc aagaaaaat   atg atg tct cca tcc      54
                                              Met Met Ser Pro Ser
                                                1               5

 caa gcc tca ctc tta ttc tta aat gta tgt att ttt att tgt gga gaa      102
 Gln Ala Ser Leu Leu Phe Leu Asn Val Cys Ile Phe Ile Cys Gly Glu
                  10                  15                  20

 gct gta caa ggt aac tgt gta cat cat tct acg gac tct tca gta gtt      150
 Ala Val Gln Gly Asn Cys Val His His Ser Thr Asp Ser Ser Val Val
              25                  30                  35

 aac att gta gaa gat gga tct aat gca aaa gat gaa agt aaa agt aat      198
 Asn Ile Val Glu Asp Gly Ser Asn Ala Lys Asp Glu Ser Lys Ser Asn
          40                  45                  50

 gat act gtt tgt aag gaa gac tgt gag gaa tca tgt gat gtt aaa act      246
 Asp Thr Val Cys Lys Glu Asp Cys Glu Glu Ser Cys Asp Val Lys Thr
      55                  60                  65

 aaa att aca cga gaa gaa aaa cat ttc atg tgt aga aat ttg caa aat      294
 Lys Ile Thr Arg Glu Glu Lys His Phe Met Cys Arg Asn Leu Gln Asn
  70                  75                  80                  85

 tct att gtt tcc tac aca aga agt acc aaa aaa cta cta agg aat atg      342
 Ser Ile Val Ser Tyr Thr Arg Ser Thr Lys Lys Leu Leu Arg Asn Met
                  90                  95                 100

 atg gat gag caa caa gct tcc ttg gat tat tta tct aat cag gtt aac      390
 Met Asp Glu Gln Gln Ala Ser Leu Asp Tyr Leu Ser Asn Gln Val Asn
             105                 110                 115

 gag ctc atg aat aga gtt ctc ctt ttg act aca gaa gtt ttt aga aaa      438
 Glu Leu Met Asn Arg Val Leu Leu Leu Thr Thr Glu Val Phe Arg Lys
         120                 125                 130

 cag ctg gat cct ttt cct cac aga cct gtt cag tca cat ggt tta gat      486
 Gln Leu Asp Pro Phe Pro His Arg Pro Val Gln Ser His Gly Leu Asp
     135                 140                 145

 tgc act gat att aag gat acc att ggc tct gtc acc aaa aca ccg agt      534
 Cys Thr Asp Ile Lys Asp Thr Ile Gly Ser Val Thr Lys Thr Pro Ser
 150                 155                 160                 165

 ggt tta tac ata att cac cca gaa gga tct agc tac cca ttt gag gta      582
 Gly Leu Tyr Ile Ile His Pro Glu Gly Ser Ser Tyr Pro Phe Glu Val
                 170                 175                 180

 atg tgt gac atg gat tac aga gga ggt gga tgg act gtg ata cag aaa      630
 Met Cys Asp Met Asp Tyr Arg Gly Gly Gly Trp Thr Val Ile Gln Lys
             185                 190                 195

 aga att gat ggg ata att gat ttc cag agg ttg tgg tgt gat tat ctg      678
 Arg Ile Asp Gly Ile Ile Asp Phe Gln Arg Leu Trp Cys Asp Tyr Leu
         200                 205                 210

 gat gga ttt gga gat ctt cta gga gaa ttt tgg cta gga ctg aaa aag      726
 Asp Gly Phe Gly Asp Leu Leu Gly Glu Phe Trp Leu Gly Leu Lys Lys
     215                 220                 225

 att ttt tat ata gta aat cag aaa aat acc agt ttt atg ctg tat gtg      774
 Ile Phe Tyr Ile Val Asn Gln Lys Asn Thr Ser Phe Met Leu Tyr Val
 230                 235                 240                 245

 gct ttg gaa tct gaa gat gac act ctt gct tat gca tca tat gat aat      822
 Ala Leu Glu Ser Glu Asp Asp Thr Leu Ala Tyr Ala Ser Tyr Asp Asn
                 250                 255                 260

 ttt tgg cta gag gat gaa acg aga ttt ttt aaa atg cac tta gga cgg      870
 Phe Trp Leu Glu Asp Glu Thr Arg Phe Phe Lys Met His Leu Gly Arg
             265                 270                 275

 tat tca gga aat gct ggt gat gca ttc cgg ggt ctc aaa aaa gaa gat      918
 Tyr Ser Gly Asn Ala Gly Asp Ala Phe Arg Gly Leu Lys Lys Glu Asp
         280                 285                 290

 aat caa aat gca atg cct ttt agc aca tca gat gtt gat aat gat ggg      966
 Asn Gln Asn Ala Met Pro Phe Ser Thr Ser Asp Val Asp Asn Asp Gly
     295                 300                 305

 tgt cgc cct gca tgc ctg gtc aat ggt cag tct gtg aag agc tgc agt     1014
 Cys Arg Pro Ala Cys Leu Val Asn Gly Gln Ser Val Lys Ser Cys Ser
 310                 315                 320                 325

 cac ctc cat aac aag acc ggc tgg tgg ttt aac gag tgt ggt cta gca     1062
 His Leu His Asn Lys Thr Gly Trp Trp Phe Asn Glu Cys Gly Leu Ala
                 330                 335                 340

 aat cta aat ggc att cat cac ttc tct gga aaa ttg ctt gca act gga     1110
 Asn Leu Asn Gly Ile His His Phe Ser Gly Lys Leu Leu Ala Thr Gly
             345                 350                 355

 att caa tgg ggc acg tgg acc aaa aac aac tca cct gtc aag att aaa     1158
 Ile Gln Trp Gly Thr Trp Thr Lys Asn Asn Ser Pro Val Lys Ile Lys
         360                 365                 370

 tct gtt tca atg aaa att aga aga atg tac aat cca tat ttt aaa taa     1206
 Ser Val Ser Met Lys Ile Arg Arg Met Tyr Asn Pro Tyr Phe Lys 
     375                 380                 385

 tctcatttaa cattgtaatg caagttctac aatgataata tattaaagat ttttaaaagt   1266

 ttatcttttc acttagtgtt tcaaacatat taggcaaaat ttaactgtag atggcattta   1326

 gatgttatga gtttaattag aaaacttcaa ttttgtagta ttctataaaa gaaaacatgg   1386

 cttattgtat gtttttactt ctgactatat taacaatata caatgaaatt tgtttcaagt   1446

 gaactacaac ttgtcttcct aaaatttata gtgattttaa aggattttgc cttttctttg   1506

 aagcattttt aaaccataat atgttgtaag gaaaattgaa gggaatattt tacttatttt   1566

 tatactttat atgattatat aatctacaga taatttctac tgaagacagt tacaataaat   1626

 aactttatgc agattaatat ataagctaca catgatgtaa aaaccttact atttctaggt   1686

 gatgccatac cattttaaaa gtagtaagag tttgctgccc aaatagtttt tcttgttttc   1746

 atatctaatc atggttaact attttgttat tgtttgtaat aaatatatgt acttttatat   1806

 cctgaaaaaa aaaaaaaa                                                 1824




      <210> 195
      <211> 2352
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (340)..(1506)

      <400> 195
 ccagacgagc tacctaagaa cagctaaaag agcacacccg tctatgtagc aaaatagtgg     60

 gaagatttat aggtagaggc gacaaaccta ccgagcctgg tgatagctgg ttgtccaaga    120

 tagaatctta gttcaacttt aaatttgccc acagaaccct ctaaatcccc ttgtaaattt    180

 aactgttagt ccaaagagga acagctcttt ggacactagg aaaaaacctt gtagagagag    240

 taaaaaattt aacacccata gtaggcctaa aagcagccac caaaaaaaaa gcggcctgac    300

 tgatatttga agaagtgttt tcatctatcc aagaaaaat   atg atg tct cca tcc     354
                                              Met Met Ser Pro Ser
                                                1               5

 caa gcc tca ctc tta ttc tta aat gta tgt att ttt att tgt gga gaa      402
 Gln Ala Ser Leu Leu Phe Leu Asn Val Cys Ile Phe Ile Cys Gly Glu
                  10                  15                  20

 gtt gta caa ggt aac tgt gta cat cat tct acg gac tct tca gta gtt      450
 Val Val Gln Gly Asn Cys Val His His Ser Thr Asp Ser Ser Val Val
              25                  30                  35

 aac att gta gaa gat gga tct aat gca aaa gat gaa agt aaa agt aat      498
 Asn Ile Val Glu Asp Gly Ser Asn Ala Lys Asp Glu Ser Lys Ser Asn
          40                  45                  50

 gat act gtt tgt aag gaa gac tgt gag gaa tca tgt gat gtt aaa act      546
 Asp Thr Val Cys Lys Glu Asp Cys Glu Glu Ser Cys Asp Val Lys Thr
      55                  60                  65

 aaa att aca cga gaa gaa aaa cat ttc atg tgt aga aat ttg caa aat      594
 Lys Ile Thr Arg Glu Glu Lys His Phe Met Cys Arg Asn Leu Gln Asn
  70                  75                  80                  85

 tct att gtt tcc tac aca aga agt acc aaa aaa cta cta agg aat atg      642
 Ser Ile Val Ser Tyr Thr Arg Ser Thr Lys Lys Leu Leu Arg Asn Met
                  90                  95                 100

 atg gat gag caa caa gct tcc ttg gat tat tta tct aat cag gtt aac      690
 Met Asp Glu Gln Gln Ala Ser Leu Asp Tyr Leu Ser Asn Gln Val Asn
             105                 110                 115

 gag ctc atg aat aga gtt ctc ctt ttg act aca gaa gtt ttt aga aaa      738
 Glu Leu Met Asn Arg Val Leu Leu Leu Thr Thr Glu Val Phe Arg Lys
         120                 125                 130

 cag ctg gat cct ttt cct cac aga cct gtt cag tca cat ggt tta gat      786
 Gln Leu Asp Pro Phe Pro His Arg Pro Val Gln Ser His Gly Leu Asp
     135                 140                 145

 tgc act gat att aag gat acc att ggc tct gtc acc aaa aca ccg agt      834
 Cys Thr Asp Ile Lys Asp Thr Ile Gly Ser Val Thr Lys Thr Pro Ser
 150                 155                 160                 165

 ggt tta tac ata att cac cca gaa gga tct agc tac cca ttt gag gta      882
 Gly Leu Tyr Ile Ile His Pro Glu Gly Ser Ser Tyr Pro Phe Glu Val
                 170                 175                 180

 atg tgt gac atg gat tac aga gga ggt gga tgg act gtg ata cag aaa      930
 Met Cys Asp Met Asp Tyr Arg Gly Gly Gly Trp Thr Val Ile Gln Lys
             185                 190                 195

 aga att gat ggg ata att gat ttc cag agg ttg tgg tgt gat tat ctg      978
 Arg Ile Asp Gly Ile Ile Asp Phe Gln Arg Leu Trp Cys Asp Tyr Leu
         200                 205                 210

 gat gga ttt gga gat ctt cta gga gaa ttt tgg cta gga ctg aaa aag     1026
 Asp Gly Phe Gly Asp Leu Leu Gly Glu Phe Trp Leu Gly Leu Lys Lys
     215                 220                 225

 att ttt tat ata gta aat cag aaa aat acc agt ttt atg ctg tat gtg     1074
 Ile Phe Tyr Ile Val Asn Gln Lys Asn Thr Ser Phe Met Leu Tyr Val
 230                 235                 240                 245

 gct ttg gaa tct gaa gat gac act ctt gct tat gca tca tat gat aat     1122
 Ala Leu Glu Ser Glu Asp Asp Thr Leu Ala Tyr Ala Ser Tyr Asp Asn
                 250                 255                 260

 ttt tgg cta gag gat gaa acg aga ttt ttt aaa atg cac tta gga cgg     1170
 Phe Trp Leu Glu Asp Glu Thr Arg Phe Phe Lys Met His Leu Gly Arg
             265                 270                 275

 tat tca gga aat gct ggt gat gca ttc cgg ggt ctc aaa aaa gaa gat     1218
 Tyr Ser Gly Asn Ala Gly Asp Ala Phe Arg Gly Leu Lys Lys Glu Asp
         280                 285                 290

 aat caa aat gca atg cct ttt agc aca tca gat gtt gat aat gat ggg     1266
 Asn Gln Asn Ala Met Pro Phe Ser Thr Ser Asp Val Asp Asn Asp Gly
     295                 300                 305

 tgt cgc cct gca tgc ctg gtc aat ggt cag tct gtg aag agc tgc agt     1314
 Cys Arg Pro Ala Cys Leu Val Asn Gly Gln Ser Val Lys Ser Cys Ser
 310                 315                 320                 325

 cac ctc cat aac aag acc ggc tgg tgg ttt aac gag tgt ggt cta gca     1362
 His Leu His Asn Lys Thr Gly Trp Trp Phe Asn Glu Cys Gly Leu Ala
                 330                 335                 340

 aat cta aat ggc att cat cac ttc tct gga aaa ttg ctt gca act gga     1410
 Asn Leu Asn Gly Ile His His Phe Ser Gly Lys Leu Leu Ala Thr Gly
             345                 350                 355

 att caa tgg ggc acg tgg acc aaa aac aac tca cct gtc aag att aaa     1458
 Ile Gln Trp Gly Thr Trp Thr Lys Asn Asn Ser Pro Val Lys Ile Lys
         360                 365                 370

 tct gtt tca atg aaa att aga aga atg tac aat cca tat ttt aaa taa     1506
 Ser Val Ser Met Lys Ile Arg Arg Met Tyr Asn Pro Tyr Phe Lys 
     375                 380                 385

 tctcatttaa cattgtaatg caagttctac aatgataata tattaaagat ttttaaaagt   1566

 ttatcttttc acttagtgtt tcaaacatat taggcaaaat ttaactgtag atggcattta   1626

 gatgttatga gtttaattag aaaacttcaa ttttgtagta ttctataaaa gaaaacatgg   1686

 cttattgtat gtttttactt ctgactatat taacaatata caatgaaatt tgtttcaagt   1746

 gaactacaac ttgtcttcct aaaatttata gtgattttaa aggattttgc cttttctttg   1806

 aagcattttt aaaccataat atgttgtaag gaaaattgaa gggaatattt tacttatttt   1866

 tatactttat atgattatat aatctacaga taatttctac tgaagacagt tacaataaat   1926

 aactttatgc agattaatat ataagctaca catgatgtaa aaaccttact atttctaggt   1986

 gatgccatac cattttaaaa gtagtaagag tttgctgccc aaatagtttt tcttgttttc   2046

 atatctaatc atggttaact attttgttat tgtttgtaat aaatatatgt acttttatat   2106

 cctgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaagg ggcgcccctt   2166

 taatttaaag gggcccttta aaccccgggt aaacccccgg agggggcttt tatagggccc   2226

 ccccttggtg tgtgcccccc ccccggggtt ttttttgacg gggggggggc cccccccact   2286

 tttttttttt taaaaaaaag agaaaattcc ccccttttgt gggaaggggg gttttttttt   2346

 ttgggg                                                              2352




      <210> 196
      <211> 2352
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (340)..(1506)

      <400> 196
 ccagacgagc tacctaagaa cagctaaaag agcacacccg tctatgtagc aaaatagtgg     60

 gaagatttat aggtagaggc gacaaaccta ccgagcctgg tgatagctgg ttgtccaaga    120

 tagaatctta gttcaacttt aaatttgccc acagaaccct ctaaatcccc ttgtaaattt    180

 aactgttagt ccaaagagga acagctcttt ggacactagg aaaaaacctt gtagagagag    240

 taaaaaattt aacacccata gtaggcctaa aagcagccac caaaaaaaaa gcggcctgac    300

 tgatatttga agaagtgttt tcatctatcc aagaaaaat   atg atg tct cca tcc     354
                                              Met Met Ser Pro Ser
                                                1               5

 caa gcc tca ctc tta ttc tta aat gta tgt att ttt att tgt gga gaa      402
 Gln Ala Ser Leu Leu Phe Leu Asn Val Cys Ile Phe Ile Cys Gly Glu
                  10                  15                  20

 gtt gta caa ggt aac tgt gta cat cat tct acg gac tct tca gta gtt      450
 Val Val Gln Gly Asn Cys Val His His Ser Thr Asp Ser Ser Val Val
              25                  30                  35

 aac att gta gaa gat gga tct aat gca aaa gat gaa agt aaa agt aat      498
 Asn Ile Val Glu Asp Gly Ser Asn Ala Lys Asp Glu Ser Lys Ser Asn
          40                  45                  50

 gat act gtt tgt aag gaa gac tgt gag gaa tca tgt gat gtt aaa act      546
 Asp Thr Val Cys Lys Glu Asp Cys Glu Glu Ser Cys Asp Val Lys Thr
      55                  60                  65

 aaa att aca cga gaa gaa aaa cat ttc atg tgt aga aat ttg caa aat      594
 Lys Ile Thr Arg Glu Glu Lys His Phe Met Cys Arg Asn Leu Gln Asn
  70                  75                  80                  85

 tct att gtt tcc tac aca aga agt acc aaa aaa cta cta agg aat atg      642
 Ser Ile Val Ser Tyr Thr Arg Ser Thr Lys Lys Leu Leu Arg Asn Met
                  90                  95                 100

 atg gat gag caa caa gct tcc ttg gat tat tta tct aat cag gtt aac      690
 Met Asp Glu Gln Gln Ala Ser Leu Asp Tyr Leu Ser Asn Gln Val Asn
             105                 110                 115

 gag ctc atg aat aga gtt ctc ctt ttg act aca gaa gtt ttt aga aaa      738
 Glu Leu Met Asn Arg Val Leu Leu Leu Thr Thr Glu Val Phe Arg Lys
         120                 125                 130

 cag ctg gat cct ttt cct cac aga cct gtt cag tca cat ggt tta gat      786
 Gln Leu Asp Pro Phe Pro His Arg Pro Val Gln Ser His Gly Leu Asp
     135                 140                 145

 tgc act gat att aag gat acc att ggc tct gtc acc aaa aca ccg agt      834
 Cys Thr Asp Ile Lys Asp Thr Ile Gly Ser Val Thr Lys Thr Pro Ser
 150                 155                 160                 165

 ggt tta tac ata att cac cca gaa gga tct agc tac cca ttt gag gta      882
 Gly Leu Tyr Ile Ile His Pro Glu Gly Ser Ser Tyr Pro Phe Glu Val
                 170                 175                 180

 atg tgt gac atg gat tac aga gga ggt gga tgg act gtg ata cag aaa      930
 Met Cys Asp Met Asp Tyr Arg Gly Gly Gly Trp Thr Val Ile Gln Lys
             185                 190                 195

 aga att gat ggg ata att gat ttc cag agg ttg tgg tgt gat tat ctg      978
 Arg Ile Asp Gly Ile Ile Asp Phe Gln Arg Leu Trp Cys Asp Tyr Leu
         200                 205                 210

 gat gga ttt gga gat ctt cta gga gaa ttt tgg cta gga ctg aaa aag     1026
 Asp Gly Phe Gly Asp Leu Leu Gly Glu Phe Trp Leu Gly Leu Lys Lys
     215                 220                 225

 att ttt tat ata gta aat cag aaa aat acc agt ttt atg ctg tat gtg     1074
 Ile Phe Tyr Ile Val Asn Gln Lys Asn Thr Ser Phe Met Leu Tyr Val
 230                 235                 240                 245

 gct ttg gaa tct gaa gat gac act ctt gct tat gca tca tat gat aat     1122
 Ala Leu Glu Ser Glu Asp Asp Thr Leu Ala Tyr Ala Ser Tyr Asp Asn
                 250                 255                 260

 ttt tgg cta gag gat gaa acg aga ttt ttt aaa atg cac tta gga cgg     1170
 Phe Trp Leu Glu Asp Glu Thr Arg Phe Phe Lys Met His Leu Gly Arg
             265                 270                 275

 tat tca gga aat gct ggt gat gca ttc cgg ggt ctc aaa aaa gaa gat     1218
 Tyr Ser Gly Asn Ala Gly Asp Ala Phe Arg Gly Leu Lys Lys Glu Asp
         280                 285                 290

 aat caa aat gca atg cct ttt agc aca tca gat gtt gat aat gat ggg     1266
 Asn Gln Asn Ala Met Pro Phe Ser Thr Ser Asp Val Asp Asn Asp Gly
     295                 300                 305

 tgt cgc cct gca tgc ctg gtc aat ggt cag tct gtg aag agc tgc agt     1314
 Cys Arg Pro Ala Cys Leu Val Asn Gly Gln Ser Val Lys Ser Cys Ser
 310                 315                 320                 325

 cac ctc cat aac aag acc ggc tgg tgg ttt aac gag tgt ggt cta gca     1362
 His Leu His Asn Lys Thr Gly Trp Trp Phe Asn Glu Cys Gly Leu Ala
                 330                 335                 340

 aat cta aat ggc att cat cac ttc tct gga aaa ttg ctt gca act gga     1410
 Asn Leu Asn Gly Ile His His Phe Ser Gly Lys Leu Leu Ala Thr Gly
             345                 350                 355

 att caa tgg ggc acg tgg acc aaa aac aac tca cct gtc aag att aaa     1458
 Ile Gln Trp Gly Thr Trp Thr Lys Asn Asn Ser Pro Val Lys Ile Lys
         360                 365                 370

 tct gtt tca atg aaa att aga aga atg tac aat cca tat ttt aaa taa     1506
 Ser Val Ser Met Lys Ile Arg Arg Met Tyr Asn Pro Tyr Phe Lys 
     375                 380                 385

 tctcatttaa cattgtaatg caagttctac aatgataata tattaaagat ttttaaaagt   1566

 ttatcttttc acttagtgtt tcaaacatat taggcaaaat ttaactgtag atggcattta   1626

 gatgttatga gtttaattag aaaacttcaa ttttgtagta ttctataaaa gaaaacatgg   1686

 cttattgtat gtttttactt ctgactatat taacaatata caatgaaatt tgtttcaagt   1746

 gaactacaac ttgtcttcct aaaatttata gtgattttaa aggattttgc cttttctttg   1806

 aagcattttt aaaccataat atgttgtaag gaaaattgaa gggaatattt tacttatttt   1866

 tatactttat atgattatat aatctacaga taatttctac tgaagacagt tacaataaat   1926

 aactttatgc agattaatat ataagctaca catgatgtaa aaaccttact atttctaggt   1986

 gatgccatac cattttaaaa gtagtaagag tttgctgccc aaatagtttt tcttgttttc   2046

 atatctaatc atggttaact attttgttat tgtttgtaat aaatatatgt acttttatat   2106

 cctgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaagg ggcgcccctt   2166

 taatttaaag gggcccttta aaccccgggt aaacccccgg agggggcttt tatagggccc   2226

 ccccttggtg tgtgcccccc ccccggggtt ttttttgacg gggggggggc cccccccact   2286

 tttttttttt taaaaaaaag agaaaattcc ccccttttgt gggaaggggg gttttttttt   2346

 ttgggg                                                              2352




      <210> 197
      <211> 901
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (497)..(841)

      <400> 197
 tccatcttga aaaatgcatg atttaataat gagaaatctt ataggaatca ttccacctaa     60

 agagaactat gctatagaaa ggcgggctat actttctgga aggaataaaa caagtagtaa    120

 aaaaaaaaaa gtaagcatcg gtatcaatat cgcattcttt taaaaggtaa tgcatgcatt    180

 gtgacctaat cctcttgtat gaggctttgg aaaagaacca ggaatggcat agagagaaaa    240

 actttcattc caaaattaat ctccagacaa aggggataga aacaaagtaa acaacatctc    300

 ctgctgcttt cagagtgaga cggggccaaa tagttaccac agatgagcag cttcatggac    360

 tactgtttag gttcttgtga atcagtccag tgtaaaaaat cacctattat taatccaact    420

 ccattctcta tagaagagtt tcttaaagta gtccacagat gacttactat aggatcgcct    480

 ggaaagcttg ttagaa    atg cac att cct ggt gtc tac cca aat caa tgg     529
                      Met His Ile Pro Gly Val Tyr Pro Asn Gln Trp
                        1               5                  10

 aat aca aat ttt tat tta ttt att tat ttt gag gca gaa tct cac tct      577
 Asn Thr Asn Phe Tyr Leu Phe Ile Tyr Phe Glu Ala Glu Ser His Ser
              15                  20                  25

 gtc gcc cag act gga cta cag tgg cgc cat ctc ggc tca ctg caa ctt      625
 Val Ala Gln Thr Gly Leu Gln Trp Arg His Leu Gly Ser Leu Gln Leu
          30                  35                  40

 ccg cct ccc agg ttc aag cga ttc tcc tgc ctc agc ctc ccg agt agg      673
 Pro Pro Pro Arg Phe Lys Arg Phe Ser Cys Leu Ser Leu Pro Ser Arg
      45                  50                  55

 tgg gat tat agg cac acg cca tca tgc cca gct aat ttt ttt gta ctt      721
 Trp Asp Tyr Arg His Thr Pro Ser Cys Pro Ala Asn Phe Phe Val Leu
  60                  65                  70                  75

 tta gta gag acg ggg ttt cac cat gtc gac caa gct ggt ctt gat ctc      769
 Leu Val Glu Thr Gly Phe His His Val Asp Gln Ala Gly Leu Asp Leu
                  80                  85                  90

 ctg act tca agt gat tca ccc gcc ttg gcc tcc aaa agt gct agg att      817
 Leu Thr Ser Ser Asp Ser Pro Ala Leu Ala Ser Lys Ser Ala Arg Ile
              95                 100                 105

 aca ggc gtg agc cac cat gcc tag cctgggaata ccctcgtgcc aagctgaggg     871
 Thr Gly Val Ser His His Ala 
         110

 tgatcaaatc gaagggttca aaagttggcg                                     901




      <210> 198
      <211> 987
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(355)

      <400> 198
 tccgccgccc ctcctcctcg tccctccctc aaggcccgga agcgaaagcc tctccacctc     60

 ttccgagcgg ggtcacggcc cggccgtcgg taacctggtt tccgagagtg ccgggcggtc    120

 ggcgggtcag ggcagcccgg ggcctgacgc c   atg tcc cgg aac ctg cgc acc     172
                                      Met Ser Arg Asn Leu Arg Thr
                                        1               5

 gcg ctc att ttc ggc ggc ttc atc tcc ctg atc ggc gcc gcc ttc tat      220
 Ala Leu Ile Phe Gly Gly Phe Ile Ser Leu Ile Gly Ala Ala Phe Tyr
          10                  15                  20

 ccc atc tac ttc cgg ccc cta atg aga ttg gag gag tac aag aag gaa      268
 Pro Ile Tyr Phe Arg Pro Leu Met Arg Leu Glu Glu Tyr Lys Lys Glu
      25                  30                  35

 caa gct ata aat cgg gct gga att gtt caa gag gat gtg cag cca cca      316
 Gln Ala Ile Asn Arg Ala Gly Ile Val Gln Glu Asp Val Gln Pro Pro
  40                  45                  50                  55

 ggg tta aaa gtg tgg tct gat cca ttt ggc agg aaa tga gagggctgtc       365
 Gly Leu Lys Val Trp Ser Asp Pro Phe Gly Arg Lys 
                  60                  65

 atcagctctg attaagaaag gagatttctt catgctttcg attctgcatg gggtacagcc    425

 agtcacctca ccagagaatg acggctggag aagaaaactc tgtaatacca taaataagag    485

 tgcttgtaat aaaagactgt gcacaaggat taatatttcc cttcttaagt atcaaaagaa    545

 ctctggaaca aattatacca ttaggaaggt tttcatgatt cagttgattt tccaaaaatg    605

 aagctatctc acccagctgg gtttggagga gcaatctgct tattattctg tcgttaccac    665

 ttactcaagc gagctgtgat atgaatacaa gcaaccagtg ggctcgggaa ggtccgggtc    725

 tcttctgcca tcttccagat aagagatttc agtaaaaaac tgccatgctg agctgcctta    785

 tagagctctt cgaaaatgtt cgagttgata aagctctttg aggacaaggt acttcgtgca    845

 cctcatgctg aagattgcac catgttggaa aataaatatg aagcaagtca aactagatgc    905

 atacacttgt gtagaaatca ataatcaatt aatagaagtg aaaaaataga cattaaaatg    965

 atttatttct aaaaaaaaaa aa                                             987




      <210> 199
      <211> 2131
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (236)..(1741)

      <400> 199
 ggaacgagga ggtggagaat tgagagcacg atgcatacac aggtgtttct gagtagtaat     60

 tagatcgctg tgaaggaaaa agcacacctt tgagttttca cctgtgaaca ctatagcgct    120

 gagagagaca gtctgaaagc agaggaagac atcgatcagt aacaccaaga gacaccaaag    180

 ttgaaagttt tgttttcttt ccctctgttt tatttttccc ccgtgtgtcc ctact atg     238
                                                              Met
                                                                1

 gtc aga aag cct gtt gtg tcc acc atc tcc aaa gga ggt tac ctg cag      286
 Val Arg Lys Pro Val Val Ser Thr Ile Ser Lys Gly Gly Tyr Leu Gln
               5                  10                  15

 gga aat gtt aac ggg agg ctg cct tcc ctg ggc aac aag gag cca cct      334
 Gly Asn Val Asn Gly Arg Leu Pro Ser Leu Gly Asn Lys Glu Pro Pro
          20                  25                  30

 ggg cag gag aaa gtg cag ctg aag agg aaa gtc act tta ctg agg gga      382
 Gly Gln Glu Lys Val Gln Leu Lys Arg Lys Val Thr Leu Leu Arg Gly
      35                  40                  45

 gtc tcc att atc att ggc acc atc att gga gca gga atc ttc atc tct      430
 Val Ser Ile Ile Ile Gly Thr Ile Ile Gly Ala Gly Ile Phe Ile Ser
  50                  55                  60                  65

 cct aag ggc gtg ctc cag aac acg ggc agc gtg ggc atg tct ctg acc      478
 Pro Lys Gly Val Leu Gln Asn Thr Gly Ser Val Gly Met Ser Leu Thr
                  70                  75                  80

 atc tgg acg gtg tgt ggg gtc ctg tca cta ttt gga gct ttg tct tat      526
 Ile Trp Thr Val Cys Gly Val Leu Ser Leu Phe Gly Ala Leu Ser Tyr
              85                  90                  95

 gct gaa ttg gga aca act ata aag aaa tct gga ggt cat tac aca tat      574
 Ala Glu Leu Gly Thr Thr Ile Lys Lys Ser Gly Gly His Tyr Thr Tyr
         100                 105                 110

 att ttg gaa gtc ttt ggt cca tta cca gct ttt gta cga gtc tgg gtg      622
 Ile Leu Glu Val Phe Gly Pro Leu Pro Ala Phe Val Arg Val Trp Val
     115                 120                 125

 gaa ctc ctc ata ata cgc cct gca gct act gct gtg ata tcc ctg gca      670
 Glu Leu Leu Ile Ile Arg Pro Ala Ala Thr Ala Val Ile Ser Leu Ala
 130                 135                 140                 145

 ttt gga cgc tac att ctg gaa cca ttt ttt att caa tgt gaa atc cct      718
 Phe Gly Arg Tyr Ile Leu Glu Pro Phe Phe Ile Gln Cys Glu Ile Pro
                 150                 155                 160

 gaa ctt gcg atc aag ctc att aca gct gtg ggc ata act gta gtg atg      766
 Glu Leu Ala Ile Lys Leu Ile Thr Ala Val Gly Ile Thr Val Val Met
             165                 170                 175

 gtc cta aat agc atg agt gtc agc tgg agc gcc cgg atc cag att ttc      814
 Val Leu Asn Ser Met Ser Val Ser Trp Ser Ala Arg Ile Gln Ile Phe
         180                 185                 190

 tta acc ttt tgc aag ctc aca gca att ctg ata att ata gtc cct gga      862
 Leu Thr Phe Cys Lys Leu Thr Ala Ile Leu Ile Ile Ile Val Pro Gly
     195                 200                 205

 gtt atg cag cta att aaa ggt caa acg cag aac ttt aaa gac gcg ttt      910
 Val Met Gln Leu Ile Lys Gly Gln Thr Gln Asn Phe Lys Asp Ala Phe
 210                 215                 220                 225

 tca gga aga gat tca agt att acg cgg ttg cca ctg gct ttt tat tat      958
 Ser Gly Arg Asp Ser Ser Ile Thr Arg Leu Pro Leu Ala Phe Tyr Tyr
                 230                 235                 240

 gga atg tat gca tat gct ggc tgg ttt tac ctc aac ttt gtt act gaa     1006
 Gly Met Tyr Ala Tyr Ala Gly Trp Phe Tyr Leu Asn Phe Val Thr Glu
             245                 250                 255

 gaa gta gaa aac cct gaa aaa acc att ccc ctt gca ata tgt ata tcc     1054
 Glu Val Glu Asn Pro Glu Lys Thr Ile Pro Leu Ala Ile Cys Ile Ser
         260                 265                 270

 atg gcc att gtc acc att ggc tat gtg ctg aca aat gtg gcc tac ttt     1102
 Met Ala Ile Val Thr Ile Gly Tyr Val Leu Thr Asn Val Ala Tyr Phe
     275                 280                 285

 acg acc att aat gct gag gag ctg ctg ctt tca aat gca gtg gca gtg     1150
 Thr Thr Ile Asn Ala Glu Glu Leu Leu Leu Ser Asn Ala Val Ala Val
 290                 295                 300                 305

 acc ttt tct gag cgg cta ctg gga aat ttc tca tta gca gtt ccg atc     1198
 Thr Phe Ser Glu Arg Leu Leu Gly Asn Phe Ser Leu Ala Val Pro Ile
                 310                 315                 320

 ttt gtt gcc ctc tcc tgc ttt ggc tcc atg aac ggt ggt gtg ttt gct     1246
 Phe Val Ala Leu Ser Cys Phe Gly Ser Met Asn Gly Gly Val Phe Ala
             325                 330                 335

 gtc tcc agg tta ttc tat gtt gcg tct cga gag ggt cac ctt cca gaa     1294
 Val Ser Arg Leu Phe Tyr Val Ala Ser Arg Glu Gly His Leu Pro Glu
         340                 345                 350

 atc ctc tcc atg att cat gtc cgc aag cac act cct cta cca gct gtt     1342
 Ile Leu Ser Met Ile His Val Arg Lys His Thr Pro Leu Pro Ala Val
     355                 360                 365

 att gtt ttg cac cct ttg aca atg ata atg ctc ttc tct gga gac ctc     1390
 Ile Val Leu His Pro Leu Thr Met Ile Met Leu Phe Ser Gly Asp Leu
 370                 375                 380                 385

 gac agt ctt ttg aat ttc ctc agt ttt gcc agg tgg ctt ttt att ggg     1438
 Asp Ser Leu Leu Asn Phe Leu Ser Phe Ala Arg Trp Leu Phe Ile Gly
                 390                 395                 400

 ctg gca gtt gct ggg ctg att tat ctt cga tac aaa tgc cca gat atg     1486
 Leu Ala Val Ala Gly Leu Ile Tyr Leu Arg Tyr Lys Cys Pro Asp Met
             405                 410                 415

 cat cgt cct ttc aag gtg cca ctg ttc atc cca gct ttg ttt tcc ttc     1534
 His Arg Pro Phe Lys Val Pro Leu Phe Ile Pro Ala Leu Phe Ser Phe
         420                 425                 430

 aca tgc ctc ttc atg gtt gcc ctt tcc ctc tat tcg gac cca ttt agt     1582
 Thr Cys Leu Phe Met Val Ala Leu Ser Leu Tyr Ser Asp Pro Phe Ser
     435                 440                 445

 aca ggg att ggc ttc gtc atc act ctg act gga gtc cct gcg tat tat     1630
 Thr Gly Ile Gly Phe Val Ile Thr Leu Thr Gly Val Pro Ala Tyr Tyr
 450                 455                 460                 465

 ctc ttt att ata tgg gac aag aaa ccc agg tgg ttt aga ata atg tca     1678
 Leu Phe Ile Ile Trp Asp Lys Lys Pro Arg Trp Phe Arg Ile Met Ser
                 470                 475                 480

 gag aaa ata acc aga aca tta caa ata ata ctg gaa gtt gta cca gaa     1726
 Glu Lys Ile Thr Arg Thr Leu Gln Ile Ile Leu Glu Val Val Pro Glu
             485                 490                 495

 gaa gat aag tta tga actaatggac ttgagatctt ggcaatctgc ccaaggggag     1781
 Glu Asp Lys Leu 
         500

 acacaaaata gggattttta cttcattttc tgaaagtcta gagaattaca actttggtga   1841

 taaacaaaag gagtcagtta tttttattca tatattttag catattcgaa ctaatttcta   1901

 agaaatttag ttataactct atgtagttat agaaagtgaa tatgcagtta ttctatgagt   1961

 cgcacaattc ttgagtctct gatacctacc tattggggtt aggagaaaag actagacaat   2021

 tactatgtgg tcattctcta caacatatgt tagcacggca aagaaccttc aaattgaaga   2081

 ctgagatttt tctgtatata tgggttttgg aaagatggtt ttacacacta              2131




      <210> 200
      <211> 1986
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1986)

      <400> 200
  atg gtg gaa ggt gaa ggg gaa gca ggc acc ttc ttc aca agg tgg cag      48
  Met Val Glu Gly Glu Gly Glu Ala Gly Thr Phe Phe Thr Arg Trp Gln
    1               5                  10                  15

 gag gga atg tct gcg aga acg agg aag tgc cac act tta aaa cca tca       96
 Glu Gly Met Ser Ala Arg Thr Arg Lys Cys His Thr Leu Lys Pro Ser
              20                  25                  30

 gct ctc gtg aga act cac aaa cta tca gaa cag cgt gga tct gaa act      144
 Ala Leu Val Arg Thr His Lys Leu Ser Glu Gln Arg Gly Ser Glu Thr
          35                  40                  45

 cag cac cga ggc tct gct ccc cac tct gag agt gat cta cca gag cag      192
 Gln His Arg Gly Ser Ala Pro His Ser Glu Ser Asp Leu Pro Glu Gln
      50                  55                  60

 gaa gag gag att ctg gga tct gat gat gat gag caa gaa gat cct aat      240
 Glu Glu Glu Ile Leu Gly Ser Asp Asp Asp Glu Gln Glu Asp Pro Asn
  65                  70                  75                  80

 gat tat tgt aaa gga ggt tat cat ctt gtg aaa att gga gat cta ttc      288
 Asp Tyr Cys Lys Gly Gly Tyr His Leu Val Lys Ile Gly Asp Leu Phe
                  85                  90                  95

 aat ggg aga tac cat gtg atc cga aag tta ggc tgg gga cac ttt tca      336
 Asn Gly Arg Tyr His Val Ile Arg Lys Leu Gly Trp Gly His Phe Ser
             100                 105                 110

 aca gta tgg tta tca tgg gat att cag ggg aag aaa ttt gtg gca atg      384
 Thr Val Trp Leu Ser Trp Asp Ile Gln Gly Lys Lys Phe Val Ala Met
         115                 120                 125

 aaa gta gtt aaa agt gct gaa cat tac act gaa aca gca cta gat gaa      432
 Lys Val Val Lys Ser Ala Glu His Tyr Thr Glu Thr Ala Leu Asp Glu
     130                 135                 140

 atc cgg ttg ctg aag tca gtg tta cag ggt ctt gat tat tta cat acc      480
 Ile Arg Leu Leu Lys Ser Val Leu Gln Gly Leu Asp Tyr Leu His Thr
 145                 150                 155                 160

 aag tgc cgt atc atc cac act gac att aaa cca gag aac atc tta ttg      528
 Lys Cys Arg Ile Ile His Thr Asp Ile Lys Pro Glu Asn Ile Leu Leu
                 165                 170                 175

 tca gtg aat gag cag tac att cgg agg ctg gct gca gaa gca aca gaa      576
 Ser Val Asn Glu Gln Tyr Ile Arg Arg Leu Ala Ala Glu Ala Thr Glu
             180                 185                 190

 tgg cag cga tct gga gct cct ccg cct tcc gga tct gca gtc agt act      624
 Trp Gln Arg Ser Gly Ala Pro Pro Pro Ser Gly Ser Ala Val Ser Thr
         195                 200                 205

 gct ccc cag cct aaa cca gct gac aaa atg tca aag aat aag aag aag      672
 Ala Pro Gln Pro Lys Pro Ala Asp Lys Met Ser Lys Asn Lys Lys Lys
     210                 215                 220

 aaa ttg aag aag aag cag aag cgc cag gca gaa tta cta gag aag cga      720
 Lys Leu Lys Lys Lys Gln Lys Arg Gln Ala Glu Leu Leu Glu Lys Arg
 225                 230                 235                 240

 atg cag gaa att gag gaa atg gag aaa gag tcg ggc cct ggg caa aaa      768
 Met Gln Glu Ile Glu Glu Met Glu Lys Glu Ser Gly Pro Gly Gln Lys
                 245                 250                 255

 aga cca aac aag caa gaa gaa tca gag agt cct gtt gaa aga ccc ttg      816
 Arg Pro Asn Lys Gln Glu Glu Ser Glu Ser Pro Val Glu Arg Pro Leu
             260                 265                 270

 aaa gag aac cca cct aat aaa atg acc caa gaa aaa ctt gaa gag tca      864
 Lys Glu Asn Pro Pro Asn Lys Met Thr Gln Glu Lys Leu Glu Glu Ser
         275                 280                 285

 agt acc att ggc cag gat caa acg ctt atg gaa cgt gat aca gag ggt      912
 Ser Thr Ile Gly Gln Asp Gln Thr Leu Met Glu Arg Asp Thr Glu Gly
     290                 295                 300

 ggt gca gca gaa att aat tgc aat gga gtg att gaa gtc att aat tat      960
 Gly Ala Ala Glu Ile Asn Cys Asn Gly Val Ile Glu Val Ile Asn Tyr
 305                 310                 315                 320

 act cag aac agt aat aat gaa aca ttg aga cat aaa gag gat cta cat     1008
 Thr Gln Asn Ser Asn Asn Glu Thr Leu Arg His Lys Glu Asp Leu His
                 325                 330                 335

 aat gct aat gac tgt gat gtc caa aat ttg aat cag gaa tct agt ttc     1056
 Asn Ala Asn Asp Cys Asp Val Gln Asn Leu Asn Gln Glu Ser Ser Phe
             340                 345                 350

 cta agc tcc caa aat gga gac agc agc aca tct caa gaa aca gac tct     1104
 Leu Ser Ser Gln Asn Gly Asp Ser Ser Thr Ser Gln Glu Thr Asp Ser
         355                 360                 365

 tgt aca cct ata aca tct gag gtg tca gac acc atg gtg tgc cag tct     1152
 Cys Thr Pro Ile Thr Ser Glu Val Ser Asp Thr Met Val Cys Gln Ser
     370                 375                 380

 tcc tca act gta ggt cag tca ttc agt gaa caa cac att agc caa ctt     1200
 Ser Ser Thr Val Gly Gln Ser Phe Ser Glu Gln His Ile Ser Gln Leu
 385                 390                 395                 400

 caa gaa agc att cgg gca gag ata ccc tgt gaa gat gaa caa gag caa     1248
 Gln Glu Ser Ile Arg Ala Glu Ile Pro Cys Glu Asp Glu Gln Glu Gln
                 405                 410                 415

 gaa cat aac gga cca ctg gac aac aaa gga aaa tcc acg gct gga aat     1296
 Glu His Asn Gly Pro Leu Asp Asn Lys Gly Lys Ser Thr Ala Gly Asn
             420                 425                 430

 ttt ctt gtt aat ccc ctt gag cca aaa aat gca gaa aag ctc aag gtg     1344
 Phe Leu Val Asn Pro Leu Glu Pro Lys Asn Ala Glu Lys Leu Lys Val
         435                 440                 445

 aag att gct gac ctt gga aat gct tgt tgg gtg cac aaa cat ttc act     1392
 Lys Ile Ala Asp Leu Gly Asn Ala Cys Trp Val His Lys His Phe Thr
     450                 455                 460

 gaa gat att caa aca agg caa tat cgt tcc ttg gaa gtt cta atc gga     1440
 Glu Asp Ile Gln Thr Arg Gln Tyr Arg Ser Leu Glu Val Leu Ile Gly
 465                 470                 475                 480

 tct ggc tat aat acc cct gct gac att tgg agc acg gca tgc atg agc     1488
 Ser Gly Tyr Asn Thr Pro Ala Asp Ile Trp Ser Thr Ala Cys Met Ser
                 485                 490                 495

 act aaa cac cag gac tgg tta ctt aat tat gtt act tct cca tat cta     1536
 Thr Lys His Gln Asp Trp Leu Leu Asn Tyr Val Thr Ser Pro Tyr Leu
             500                 505                 510

 aga cga gca gcc ttt gaa ctg gcc aca ggt gac tat ttg ttt gaa cct     1584
 Arg Arg Ala Ala Phe Glu Leu Ala Thr Gly Asp Tyr Leu Phe Glu Pro
         515                 520                 525

 cat tca ggg gaa gag tac act cga gat gaa gac cac att gtg cac att     1632
 His Ser Gly Glu Glu Tyr Thr Arg Asp Glu Asp His Ile Val His Ile
     530                 535                 540

 ata gag ctg ata ggc aga att cca aga cgc ttt tcc ctc agt ggg aaa     1680
 Ile Glu Leu Ile Gly Arg Ile Pro Arg Arg Phe Ser Leu Ser Gly Lys
 545                 550                 555                 560

 tat tca caa gac ttc ttc agt cac aga gat cac att gca ttg atc ata     1728
 Tyr Ser Gln Asp Phe Phe Ser His Arg Asp His Ile Ala Leu Ile Ile
                 565                 570                 575

 gaa ctt ctg ggg aag gtg cct cgc aag ctc att gtg gca gga aaa tat     1776
 Glu Leu Leu Gly Lys Val Pro Arg Lys Leu Ile Val Ala Gly Lys Tyr
             580                 585                 590

 tcc aag gaa ttt ttc acc aaa aaa ggt gac ctg aaa cat atc acg aag     1824
 Ser Lys Glu Phe Phe Thr Lys Lys Gly Asp Leu Lys His Ile Thr Lys
         595                 600                 605

 ctg aaa cct tgg ggc ctt ttt gag gtt cta gtg gag aag tat gag tgg     1872
 Leu Lys Pro Trp Gly Leu Phe Glu Val Leu Val Glu Lys Tyr Glu Trp
     610                 615                 620

 tcg cag gaa gag gca gct ggc ttc aca gat ttc tta ctg ccc atg ttg     1920
 Ser Gln Glu Glu Ala Ala Gly Phe Thr Asp Phe Leu Leu Pro Met Leu
 625                 630                 635                 640

 gag ctg atc cct gag aag aga gcc act gcc gcc gag tgt ctc cgg cac     1968
 Glu Leu Ile Pro Glu Lys Arg Ala Thr Ala Ala Glu Cys Leu Arg His
                 645                 650                 655

 cct tgg ctt aac tcc taa                                             1986
 Pro Trp Leu Asn Ser 
             660





      <210> 201
      <211> 762
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(414)

      <400> 201
  atg att aat cca gag ctg cgg gat ggc aga gct gat ggc ttc ata cat      48
  Met Ile Asn Pro Glu Leu Arg Asp Gly Arg Ala Asp Gly Phe Ile His
    1               5                  10                  15

 cgg ata gcc aca tgg tcc aag cat gct aaa cct gtg gca tgt tca ggg       96
 Arg Ile Ala Thr Trp Ser Lys His Ala Lys Pro Val Ala Cys Ser Gly
              20                  25                  30

 gac tgg ctt gga gtg aga gat aag tgt ttc tat ttt tct gat gat acc      144
 Asp Trp Leu Gly Val Arg Asp Lys Cys Phe Tyr Phe Ser Asp Asp Thr
          35                  40                  45

 aga aat tgg aca gcc agt aaa ata ttt tgt agt ttg cag aaa gca gaa      192
 Arg Asn Trp Thr Ala Ser Lys Ile Phe Cys Ser Leu Gln Lys Ala Glu
      50                  55                  60

 ctt gct cag att gat aca caa gaa gac atg gaa ttt ttg aag agg tac      240
 Leu Ala Gln Ile Asp Thr Gln Glu Asp Met Glu Phe Leu Lys Arg Tyr
  65                  70                  75                  80

 gca gga act gat atg cac tgg att gga cta agc agg aaa caa gga gat      288
 Ala Gly Thr Asp Met His Trp Ile Gly Leu Ser Arg Lys Gln Gly Asp
                  85                  90                  95

 tct tgg aaa tgg aca aat ggc acc aca ttc aat ggc cat caa act cca      336
 Ser Trp Lys Trp Thr Asn Gly Thr Thr Phe Asn Gly His Gln Thr Pro
             100                 105                 110

 aat ggt ctt gca act gga gcc tcc gac aat ggc ttc ttc tgc tgg gac      384
 Asn Gly Leu Ala Thr Gly Ala Ser Asp Asn Gly Phe Phe Cys Trp Asp
         115                 120                 125

 ccc tta gat agg cct ctg agg gag ctc tga c tgccgtttcc ccaaaacaat      435
 Pro Leu Asp Arg Pro Leu Arg Glu Leu 
     130                 135

 gtcccctgtc agcaggaagc agttaaatca gtcttcatcc ttatccttaa tataacggca    495

 gttagatgta cttacaccac tggttccatt gtgcgtcaag atcgcatctc tctggcaaat    555

 gcccttaaat gtggagctac agtcttcaga atacacccag tttcctgtga taacggcaca    615

 gctcctgtca tcagttggtc caatcactga aaacaattct ggaactaaaa agtgttcatc    675

 tatccacatc cataggttcc cttggaatgt aacatatagt ccaatccaac caaaatgtcc    735

 agtttttaaa ctgttctgta tgaactc                                        762




      <210> 202
      <211> 4817
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (110)..(4501)

      <400> 202
 acggaatatt cctgggttgc tggctctctg tgacaatttg gctactctgg aaacattggt     60

 ttatgaagcc aggtgtgatg taactctaac cctgaaagaa ctccagcag    atg aaa     115
                                                          Met Lys
                                                            1

 gac att gaa aaa cta aga tta ctg atg aat agt tgt tct gag gat aaa      163
 Asp Ile Glu Lys Leu Arg Leu Leu Met Asn Ser Cys Ser Glu Asp Lys
           5                  10                  15

 tat gtg aca agt gcc tac cag tgg atg gtt ccc ttt ctt cat cgt tgt      211
 Tyr Val Thr Ser Ala Tyr Gln Trp Met Val Pro Phe Leu His Arg Cys
      20                  25                  30

 gag aaa cag tcg cct ggt gtg gct aat gag cta tta aaa gaa tat tta      259
 Glu Lys Gln Ser Pro Gly Val Ala Asn Glu Leu Leu Lys Glu Tyr Leu
  35                  40                  45                  50

 gta act tta gct aaa ggg gac tta aaa ttt ccc ctg aag ata ttt cag      307
 Val Thr Leu Ala Lys Gly Asp Leu Lys Phe Pro Leu Lys Ile Phe Gln
                  55                  60                  65

 cat tcc aaa cca gat ctg cag caa aaa att att cct gat cag gac caa      355
 His Ser Lys Pro Asp Leu Gln Gln Lys Ile Ile Pro Asp Gln Asp Gln
              70                  75                  80

 ctg atg gca ata gca cta gag tgc atc tat acc tgt gaa cga aat gat      403
 Leu Met Ala Ile Ala Leu Glu Cys Ile Tyr Thr Cys Glu Arg Asn Asp
          85                  90                  95

 caa ctc tgt ctt tgc tat gac cta cta gaa tgt ctg cca gaa aga gga      451
 Gln Leu Cys Leu Cys Tyr Asp Leu Leu Glu Cys Leu Pro Glu Arg Gly
     100                 105                 110

 tat ggt gat aag aca gag gca acc aca aag ctt cat gac atg gta gac      499
 Tyr Gly Asp Lys Thr Glu Ala Thr Thr Lys Leu His Asp Met Val Asp
 115                 120                 125                 130

 caa ctg gaa caa att ctc agt gtg tca gag ctt ttg gaa aaa cat gga      547
 Gln Leu Glu Gln Ile Leu Ser Val Ser Glu Leu Leu Glu Lys His Gly
                 135                 140                 145

 ctc gag aaa cca att tca ttt gtt aaa aac act caa tct agc tca gaa      595
 Leu Glu Lys Pro Ile Ser Phe Val Lys Asn Thr Gln Ser Ser Ser Glu
             150                 155                 160

 gag gca cgc aag ctg atg gtt aga ttg acg agg cac act ggc cgg aag      643
 Glu Ala Arg Lys Leu Met Val Arg Leu Thr Arg His Thr Gly Arg Lys
         165                 170                 175

 cag cct cct gtc agt gag tct cat tgg aga acg ttg ctg caa gac atg      691
 Gln Pro Pro Val Ser Glu Ser His Trp Arg Thr Leu Leu Gln Asp Met
     180                 185                 190

 tta act atg cag cag aat gta tac aca tgt cta gat tct gat gcc tgc      739
 Leu Thr Met Gln Gln Asn Val Tyr Thr Cys Leu Asp Ser Asp Ala Cys
 195                 200                 205                 210

 tat gag ata ttt aca gaa agc ctt ctg tgc tct agt cgc ctt gaa aac      787
 Tyr Glu Ile Phe Thr Glu Ser Leu Leu Cys Ser Ser Arg Leu Glu Asn
                 215                 220                 225

 atc cac ctg gct gga cag atg atg cac tgc agt gct tgt tca gaa aat      835
 Ile His Leu Ala Gly Gln Met Met His Cys Ser Ala Cys Ser Glu Asn
             230                 235                 240

 cct cca gct ggt ata gcc cat aaa ggg aaa ccc cac tac agg gtc agc      883
 Pro Pro Ala Gly Ile Ala His Lys Gly Lys Pro His Tyr Arg Val Ser
         245                 250                 255

 tac gaa aag agt att gac ttg gtt ttg gct gcc agc aga gag tac ttc      931
 Tyr Glu Lys Ser Ile Asp Leu Val Leu Ala Ala Ser Arg Glu Tyr Phe
     260                 265                 270

 aat tct tct acc aac ctc act gat agc tgc atg gat cta gcc agg tgc      979
 Asn Ser Ser Thr Asn Leu Thr Asp Ser Cys Met Asp Leu Ala Arg Cys
 275                 280                 285                 290

 tgc tta caa ctg ata aca gac aga ccc cct gcc att caa gag gag cta     1027
 Cys Leu Gln Leu Ile Thr Asp Arg Pro Pro Ala Ile Gln Glu Glu Leu
                 295                 300                 305

 gat ctt atc caa gcc gtt gga tgt ctt gaa gaa ttt ggg gta aag atc     1075
 Asp Leu Ile Gln Ala Val Gly Cys Leu Glu Glu Phe Gly Val Lys Ile
             310                 315                 320

 ctg cct ttg caa gtg cga ttg tgc cct gat cgg atc agt ctc atc aag     1123
 Leu Pro Leu Gln Val Arg Leu Cys Pro Asp Arg Ile Ser Leu Ile Lys
         325                 330                 335

 gag tgt att tcc cag tcc ccc aca tgc tat aaa caa tcc acc aag ctt     1171
 Glu Cys Ile Ser Gln Ser Pro Thr Cys Tyr Lys Gln Ser Thr Lys Leu
     340                 345                 350

 ctg ggc ctt gct gag ctg ctg agg gtt gca ggt gag aac cca gaa gaa     1219
 Leu Gly Leu Ala Glu Leu Leu Arg Val Ala Gly Glu Asn Pro Glu Glu
 355                 360                 365                 370

 agg cgg gga cag gtt cta atc ctt tta gtg gag cag gca ctt cgc ttc     1267
 Arg Arg Gly Gln Val Leu Ile Leu Leu Val Glu Gln Ala Leu Arg Phe
                 375                 380                 385

 cat gac tac aaa gca gcc agt atg cat tgt cag gag ctg atg gcc aca     1315
 His Asp Tyr Lys Ala Ala Ser Met His Cys Gln Glu Leu Met Ala Thr
             390                 395                 400

 ggt tat cct aaa agt tgg gat gtt tgt agc cag tta gga caa tca gaa     1363
 Gly Tyr Pro Lys Ser Trp Asp Val Cys Ser Gln Leu Gly Gln Ser Glu
         405                 410                 415

 ggt tac cag gac ttg gcc act cgt caa gag ctc atg gct ttt gct ttg     1411
 Gly Tyr Gln Asp Leu Ala Thr Arg Gln Glu Leu Met Ala Phe Ala Leu
     420                 425                 430

 aca cat tgc cct cct agc agc att gaa ctt ctt ttg gca gct agc agc     1459
 Thr His Cys Pro Pro Ser Ser Ile Glu Leu Leu Leu Ala Ala Ser Ser
 435                 440                 445                 450

 tct ctg cag aca gaa att ctt tat caa aga gtg aat ttc cag atc cat     1507
 Ser Leu Gln Thr Glu Ile Leu Tyr Gln Arg Val Asn Phe Gln Ile His
                 455                 460                 465

 cat gaa gga ggg gaa aat atc agt gct tca cca tta act agt aaa gca     1555
 His Glu Gly Gly Glu Asn Ile Ser Ala Ser Pro Leu Thr Ser Lys Ala
             470                 475                 480

 gta caa gag gat gaa gta ggt gtt cca ggt agc aat tca gct gac cta     1603
 Val Gln Glu Asp Glu Val Gly Val Pro Gly Ser Asn Ser Ala Asp Leu
         485                 490                 495

 ttg cgc tgg acc act gct acc acc atg aaa gtc ctt tcc aac acc aca     1651
 Leu Arg Trp Thr Thr Ala Thr Thr Met Lys Val Leu Ser Asn Thr Thr
     500                 505                 510

 acc acc acc aaa gcg gtg ctg cag gcc gtc agt gat ggg cag tgg tgg     1699
 Thr Thr Thr Lys Ala Val Leu Gln Ala Val Ser Asp Gly Gln Trp Trp
 515                 520                 525                 530

 aag aag tct tta act tac ctt cga ccc ctt cag ggg caa aaa tgt ggt     1747
 Lys Lys Ser Leu Thr Tyr Leu Arg Pro Leu Gln Gly Gln Lys Cys Gly
                 535                 540                 545

 ggt gca tat caa atc gga act aca gcc aat gaa gat cta gag aaa caa     1795
 Gly Ala Tyr Gln Ile Gly Thr Thr Ala Asn Glu Asp Leu Glu Lys Gln
             550                 555                 560

 ggg tgt cat cct ttt tat gaa tct gtc atc tca aat cct ttt gtc gct     1843
 Gly Cys His Pro Phe Tyr Glu Ser Val Ile Ser Asn Pro Phe Val Ala
         565                 570                 575

 gag tct gaa ggg acc tat gac acc tat cag cat gtt cca gtg gaa agc     1891
 Glu Ser Glu Gly Thr Tyr Asp Thr Tyr Gln His Val Pro Val Glu Ser
     580                 585                 590

 ttt gca gaa gta ttg ctg aga act gga aaa ttg gca gag gct aaa aat     1939
 Phe Ala Glu Val Leu Leu Arg Thr Gly Lys Leu Ala Glu Ala Lys Asn
 595                 600                 605                 610

 aaa gga gaa gta ttt cca aca act gaa gtt ctc ttg caa cta gca agt     1987
 Lys Gly Glu Val Phe Pro Thr Thr Glu Val Leu Leu Gln Leu Ala Ser
                 615                 620                 625

 gaa gcc ttg cca aat gac atg acc ttg gct ctt gct tac ctt ctt gcc     2035
 Glu Ala Leu Pro Asn Asp Met Thr Leu Ala Leu Ala Tyr Leu Leu Ala
             630                 635                 640

 tta cca caa gtg tta gat gct aac cgg tgc ttt gaa aag cag tcc ccc     2083
 Leu Pro Gln Val Leu Asp Ala Asn Arg Cys Phe Glu Lys Gln Ser Pro
         645                 650                 655

 tct gca tta tct ctc cag ctg gca gcg tat tac tat agc ctc cag atc     2131
 Ser Ala Leu Ser Leu Gln Leu Ala Ala Tyr Tyr Tyr Ser Leu Gln Ile
     660                 665                 670

 tat gcc cga ttg gcc cca tgt ttc agg gac aag tgc cat cct ctt tac     2179
 Tyr Ala Arg Leu Ala Pro Cys Phe Arg Asp Lys Cys His Pro Leu Tyr
 675                 680                 685                 690

 agg gct gat ccc aaa gaa cta atc aag atg gtc acc agg cat gtg act     2227
 Arg Ala Asp Pro Lys Glu Leu Ile Lys Met Val Thr Arg His Val Thr
                 695                 700                 705

 cga cat gag cac gaa gcc tgg cct gaa gac ctt att tca ctg acc aag     2275
 Arg His Glu His Glu Ala Trp Pro Glu Asp Leu Ile Ser Leu Thr Lys
             710                 715                 720

 cag tta cac tgc tac aat gaa cgt ctc ctg gat ttc act cag gcg cag     2323
 Gln Leu His Cys Tyr Asn Glu Arg Leu Leu Asp Phe Thr Gln Ala Gln
         725                 730                 735

 atc ctt cag ggc ctt cgg aag ggt gtg gac gtg cag cgg ttt act gca     2371
 Ile Leu Gln Gly Leu Arg Lys Gly Val Asp Val Gln Arg Phe Thr Ala
     740                 745                 750

 gat gac cag tat aaa agg gaa act atc ctt ggt ctg gca gaa act cta     2419
 Asp Asp Gln Tyr Lys Arg Glu Thr Ile Leu Gly Leu Ala Glu Thr Leu
 755                 760                 765                 770

 gag gaa agc gtc tac agc att gct att tct ctg gca caa cgt tac agt     2467
 Glu Glu Ser Val Tyr Ser Ile Ala Ile Ser Leu Ala Gln Arg Tyr Ser
                 775                 780                 785

 gtc tcc cgc tgg gaa gtt ttt atg acc cat ttg gag ttc ctc ttc acg     2515
 Val Ser Arg Trp Glu Val Phe Met Thr His Leu Glu Phe Leu Phe Thr
             790                 795                 800

 gac agt ggt ttg tcc aca cta gaa att gaa aat aga gcc caa gac ctt     2563
 Asp Ser Gly Leu Ser Thr Leu Glu Ile Glu Asn Arg Ala Gln Asp Leu
         805                 810                 815

 cat ctc ttt gag act ttg aag act gat cca gaa gcc ttt cac cag cac     2611
 His Leu Phe Glu Thr Leu Lys Thr Asp Pro Glu Ala Phe His Gln His
     820                 825                 830

 atg gtc aag tat att tac cct act att ggt ggc ttt gat cac gaa agg     2659
 Met Val Lys Tyr Ile Tyr Pro Thr Ile Gly Gly Phe Asp His Glu Arg
 835                 840                 845                 850

 ctg cag tat tat ttc act ctt ctg gaa aac tgt ggc tgt gca gat ttg     2707
 Leu Gln Tyr Tyr Phe Thr Leu Leu Glu Asn Cys Gly Cys Ala Asp Leu
                 855                 860                 865

 ggg aac tgt gcc att aaa cca gaa acc cac att cga ctg ctg aag aag     2755
 Gly Asn Cys Ala Ile Lys Pro Glu Thr His Ile Arg Leu Leu Lys Lys
             870                 875                 880

 ttt aag gtt gtt gca tca ggt ctt aat tac aaa aag ctg aca gat gaa     2803
 Phe Lys Val Val Ala Ser Gly Leu Asn Tyr Lys Lys Leu Thr Asp Glu
         885                 890                 895

 aac atg agt cct ctt gaa gca ttg gag cca gtt ctt tca agt caa aat     2851
 Asn Met Ser Pro Leu Glu Ala Leu Glu Pro Val Leu Ser Ser Gln Asn
     900                 905                 910

 atc ttg tct att tcc aaa ctt gtt ccc aaa atc cct gaa aag gat gga     2899
 Ile Leu Ser Ile Ser Lys Leu Val Pro Lys Ile Pro Glu Lys Asp Gly
 915                 920                 925                 930

 cag atg ctt tcc cca agc tct ctg tac acc atc tgg tta cag aag ttg     2947
 Gln Met Leu Ser Pro Ser Ser Leu Tyr Thr Ile Trp Leu Gln Lys Leu
                 935                 940                 945

 ttc tgg act gga gac cct cat ctc att aaa caa gtc cca ggc tct tca     2995
 Phe Trp Thr Gly Asp Pro His Leu Ile Lys Gln Val Pro Gly Ser Ser
             950                 955                 960

 ccg gag tgg ctt cat gcc tat gat gtc tgc atg aag tac ttt gat cgt     3043
 Pro Glu Trp Leu His Ala Tyr Asp Val Cys Met Lys Tyr Phe Asp Arg
         965                 970                 975

 ctc cac cca ggt gac ctc atc act gtg gta gat gca gtt aca ttt tct     3091
 Leu His Pro Gly Asp Leu Ile Thr Val Val Asp Ala Val Thr Phe Ser
     980                 985                 990

 cca aaa gct gtg acc aag ctg tct gtg gaa gcc cgt aaa gag atg act     3139
 Pro Lys Ala Val Thr Lys Leu Ser Val Glu Ala Arg Lys Glu Met Thr
 995                1000                1005                1010

 aga aag gct att aag aca gtc aaa cat ttt att gag aag cca agg aaa     3187
 Arg Lys Ala Ile Lys Thr Val Lys His Phe Ile Glu Lys Pro Arg Lys
                1015                1020                1025

 aga aac tca gaa gac gaa gct caa gaa gct aag gat tct aaa gtt acc     3235
 Arg Asn Ser Glu Asp Glu Ala Gln Glu Ala Lys Asp Ser Lys Val Thr
            1030                1035                1040

 tat gca gat act ttg aat cat ctg gag aaa tca ctt gcc cac ctg gaa     3283
 Tyr Ala Asp Thr Leu Asn His Leu Glu Lys Ser Leu Ala His Leu Glu
        1045                1050                1055

 acc ctg agc cac agc ttc atc ctt tct ctg aag aat agt gag cag gaa     3331
 Thr Leu Ser His Ser Phe Ile Leu Ser Leu Lys Asn Ser Glu Gln Glu
    1060                1065                1070

 aca ctg caa aaa tac agt cac ctc tat gat ctg tcc cga tca gaa aaa     3379
 Thr Leu Gln Lys Tyr Ser His Leu Tyr Asp Leu Ser Arg Ser Glu Lys
1075                1080                1085                1090

 gag aaa ctt cat gat gaa gct gtg gct att tgt tta gat ggt cag cct     3427
 Glu Lys Leu His Asp Glu Ala Val Ala Ile Cys Leu Asp Gly Gln Pro
                1095                1100                1105

 cta gca atg att cag cag ctg cta gag gtg gca gtt ggc cct ctt gac     3475
 Leu Ala Met Ile Gln Gln Leu Leu Glu Val Ala Val Gly Pro Leu Asp
            1110                1115                1120

 atc tca ccc aag gat ata gtg cag agt gca atc atg aaa ata att tct     3523
 Ile Ser Pro Lys Asp Ile Val Gln Ser Ala Ile Met Lys Ile Ile Ser
        1125                1130                1135

 gca ttg agt ggt ggc agt gct gac ctt ggt ggg cca agg gac cca ctg     3571
 Ala Leu Ser Gly Gly Ser Ala Asp Leu Gly Gly Pro Arg Asp Pro Leu
    1140                1145                1150

 aag gtc ctg gaa ggt gtt gtt gca gca gtc cac gcc agt gtg gac aag     3619
 Lys Val Leu Glu Gly Val Val Ala Ala Val His Ala Ser Val Asp Lys
1155                1160                1165                1170

 ggt gag gag ctg gtt tca cct gag gac ctg ctg gag tgg ctg cgg cct     3667
 Gly Glu Glu Leu Val Ser Pro Glu Asp Leu Leu Glu Trp Leu Arg Pro
                1175                1180                1185

 ttc tgt gct gat gac gcc tgg ccg gtg cgg ccc cgc att cac gtg ctg     3715
 Phe Cys Ala Asp Asp Ala Trp Pro Val Arg Pro Arg Ile His Val Leu
            1190                1195                1200

 cag att ttg ggg caa tca ttt cac ctg act gag gag gac agc aag ctc     3763
 Gln Ile Leu Gly Gln Ser Phe His Leu Thr Glu Glu Asp Ser Lys Leu
        1205                1210                1215

 ctc gtg ttc ttt aga act gaa gcc att ctc aaa gcc tcc tgg ccc cag     3811
 Leu Val Phe Phe Arg Thr Glu Ala Ile Leu Lys Ala Ser Trp Pro Gln
    1220                1225                1230

 aga cag gta gac ata gct gac att gag aat gaa gag aac cgc tac tgt     3859
 Arg Gln Val Asp Ile Ala Asp Ile Glu Asn Glu Glu Asn Arg Tyr Cys
1235                1240                1245                1250

 cta ttc atg gaa ctc ctg gaa tct agt cac cac gag gct gaa ttt cag     3907
 Leu Phe Met Glu Leu Leu Glu Ser Ser His His Glu Ala Glu Phe Gln
                1255                1260                1265

 cac ttg gtt tta ctt ttg caa gct tgg cca cct atg aaa agt gaa tat     3955
 His Leu Val Leu Leu Leu Gln Ala Trp Pro Pro Met Lys Ser Glu Tyr
            1270                1275                1280

 gtc ata acc aat aat cca tgg gtg aga cta gct aca gtg atg cta acc     4003
 Val Ile Thr Asn Asn Pro Trp Val Arg Leu Ala Thr Val Met Leu Thr
        1285                1290                1295

 aga tgt acg atg gag aac aag gaa gga ttg ggg aat gaa gtt ttg aaa     4051
 Arg Cys Thr Met Glu Asn Lys Glu Gly Leu Gly Asn Glu Val Leu Lys
    1300                1305                1310

 atg tgt cgc tct ttg tat aac acc aag cag atg ctg cct gca gag ggt     4099
 Met Cys Arg Ser Leu Tyr Asn Thr Lys Gln Met Leu Pro Ala Glu Gly
1315                1320                1325                1330

 gtg aag gag ctg tgt ctg ctg ctg ctt aac cag tcc ctc ctg ctt cca     4147
 Val Lys Glu Leu Cys Leu Leu Leu Leu Asn Gln Ser Leu Leu Leu Pro
                1335                1340                1345

 tct ctg aaa ctt ctc ctc gag agc cga gat gag cat ctg cac gag atg     4195
 Ser Leu Lys Leu Leu Leu Glu Ser Arg Asp Glu His Leu His Glu Met
            1350                1355                1360

 gca ctg gag caa atc acg gca gtc act acg gtg aat gat tcc aat tgt     4243
 Ala Leu Glu Gln Ile Thr Ala Val Thr Thr Val Asn Asp Ser Asn Cys
        1365                1370                1375

 gac caa gaa ctt ctt tcc ctg ctc ctg gat gcc aag ctg ctg gtg aag     4291
 Asp Gln Glu Leu Leu Ser Leu Leu Leu Asp Ala Lys Leu Leu Val Lys
    1380                1385                1390

 tgt gtc tcc act ccc ttc tat cca cgt att gtt gac cac ctc ttg gct     4339
 Cys Val Ser Thr Pro Phe Tyr Pro Arg Ile Val Asp His Leu Leu Ala
1395                1400                1405                1410

 agc ctc cag caa ggg cgc tgg gat gca gag gag ctg ggc aga cac ctg     4387
 Ser Leu Gln Gln Gly Arg Trp Asp Ala Glu Glu Leu Gly Arg His Leu
                1415                1420                1425

 cgg gag gcc ggc cat gaa gcc gaa gcc ggg tct ctc ctt ctg gcc gtg     4435
 Arg Glu Ala Gly His Glu Ala Glu Ala Gly Ser Leu Leu Leu Ala Val
            1430                1435                1440

 agg ggg act cac cag gcc ttc aga acc ttc agt aca gcc ctc cgc gca     4483
 Arg Gly Thr His Gln Ala Phe Arg Thr Phe Ser Thr Ala Leu Arg Ala
        1445                1450                1455

 gca cag cac tgg gtg tga gggcca cctgtggccc tgctccttag cagaaaaagc     4537
 Ala Gln His Trp Val 
    1460

 atctggagtt gaatgctgtt cccagaagca acatgtgtat ctgccgattg ttctccatgg   4597

 ttccaacaaa ttgcaaataa aactgtatgg aaacgaaaaa aaatatcggc ctcgtggcct   4657

 cacggagtag ctctggagcg cttctttaag aagggaataa tgaccagcgt atgactcatg   4717

 acctgtggta ggcggaggag cggtcagttc cttaaggcgg tcggttacca agaatggata   4777

 ctggaaaact gcgcatgcca cgcgtaacaa agcttgtttt                         4817




      <210> 203
      <211> 4688
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (110)..(4372)

      <400> 203
 acggaatatt cctgggttgc tggctctctg tgacaatttg gctactctgg aaacattggt     60

 ttatgaagcc aggtgtgatg taactctaac cctgaaagaa ctccagcag    atg aaa     115
                                                          Met Lys
                                                            1

 gac att gaa aaa cta aga tta ctg atg aat agt tgt tct gag gat aaa      163
 Asp Ile Glu Lys Leu Arg Leu Leu Met Asn Ser Cys Ser Glu Asp Lys
           5                  10                  15

 tat gtg aca agt gcc tac cag tgg atg gtt ccc ttt ctt cat cgt tgt      211
 Tyr Val Thr Ser Ala Tyr Gln Trp Met Val Pro Phe Leu His Arg Cys
      20                  25                  30

 gag aaa cag tcg cct ggt gtg gct aat gag cta tta aaa gaa tat tta      259
 Glu Lys Gln Ser Pro Gly Val Ala Asn Glu Leu Leu Lys Glu Tyr Leu
  35                  40                  45                  50

 gta act tta gct aaa ggg gac tta aaa ttt ccc ctg aag ata ttt cag      307
 Val Thr Leu Ala Lys Gly Asp Leu Lys Phe Pro Leu Lys Ile Phe Gln
                  55                  60                  65

 cat tcc aaa cca gat ctg cag caa aaa att att cct gat cag gac caa      355
 His Ser Lys Pro Asp Leu Gln Gln Lys Ile Ile Pro Asp Gln Asp Gln
              70                  75                  80

 ctg atg gca ata gca cta gag tgc atc tat acc tgt gaa cga aat gat      403
 Leu Met Ala Ile Ala Leu Glu Cys Ile Tyr Thr Cys Glu Arg Asn Asp
          85                  90                  95

 caa ctc tgt ctt tgc tat gac cta cta gaa tgt ctg cca gaa aga gga      451
 Gln Leu Cys Leu Cys Tyr Asp Leu Leu Glu Cys Leu Pro Glu Arg Gly
     100                 105                 110

 tat ggt gat aag aca gag gca acc aca aag ctt cat gac atg gta gac      499
 Tyr Gly Asp Lys Thr Glu Ala Thr Thr Lys Leu His Asp Met Val Asp
 115                 120                 125                 130

 caa ctg gaa caa att ctc agt gtg tca gag ctt ttg gaa aaa cat gga      547
 Gln Leu Glu Gln Ile Leu Ser Val Ser Glu Leu Leu Glu Lys His Gly
                 135                 140                 145

 ctc gag aaa cca att tca ttt gtt aaa aac act caa tct agc tca gaa      595
 Leu Glu Lys Pro Ile Ser Phe Val Lys Asn Thr Gln Ser Ser Ser Glu
             150                 155                 160

 gag gca cgc aag ctg atg gtt aga ttg acg agg cac act ggc cgg aag      643
 Glu Ala Arg Lys Leu Met Val Arg Leu Thr Arg His Thr Gly Arg Lys
         165                 170                 175

 cag cct cct gtc agt gag tct cat tgg aga acg ttg ctg caa gac atg      691
 Gln Pro Pro Val Ser Glu Ser His Trp Arg Thr Leu Leu Gln Asp Met
     180                 185                 190

 tta act atg cag cag aat gta tac aca tgt cta gat tct gat gcc tgc      739
 Leu Thr Met Gln Gln Asn Val Tyr Thr Cys Leu Asp Ser Asp Ala Cys
 195                 200                 205                 210

 tat gag ata ttt aca gaa agc ctt ctg tgc tct agt cgc ctt gaa aac      787
 Tyr Glu Ile Phe Thr Glu Ser Leu Leu Cys Ser Ser Arg Leu Glu Asn
                 215                 220                 225

 atc cac ctg gct gga cag atg atg cac tgc agt gct tgt tca gaa aat      835
 Ile His Leu Ala Gly Gln Met Met His Cys Ser Ala Cys Ser Glu Asn
             230                 235                 240

 cct cca gct ggt ata gcc cat aaa ggg aaa ccc cac tac agg gtc agc      883
 Pro Pro Ala Gly Ile Ala His Lys Gly Lys Pro His Tyr Arg Val Ser
         245                 250                 255

 tac gaa aag agt att gac ttg gtt ttg gct gcc agc aga gag tac ttc      931
 Tyr Glu Lys Ser Ile Asp Leu Val Leu Ala Ala Ser Arg Glu Tyr Phe
     260                 265                 270

 aat tct tct acc aac ctc act gat agc tgc atg gat cta gcc agg tgc      979
 Asn Ser Ser Thr Asn Leu Thr Asp Ser Cys Met Asp Leu Ala Arg Cys
 275                 280                 285                 290

 tgc tta caa ctg ata aca gac aga ccc cct gcc att caa gag gag cta     1027
 Cys Leu Gln Leu Ile Thr Asp Arg Pro Pro Ala Ile Gln Glu Glu Leu
                 295                 300                 305

 gat ctt atc caa gcc gtt gga tgt ctt gaa gaa ttt ggg gta aag atc     1075
 Asp Leu Ile Gln Ala Val Gly Cys Leu Glu Glu Phe Gly Val Lys Ile
             310                 315                 320

 ctg cct ttg caa gtg cga ttg tgc cct gat cgg atc agt ctc atc aag     1123
 Leu Pro Leu Gln Val Arg Leu Cys Pro Asp Arg Ile Ser Leu Ile Lys
         325                 330                 335

 gag tgt att tcc cag tcc ccc aca tgc tat aaa caa tcc acc aag ctt     1171
 Glu Cys Ile Ser Gln Ser Pro Thr Cys Tyr Lys Gln Ser Thr Lys Leu
     340                 345                 350

 ctg ggc ctt gct gag ctg ctg agg gtt gca ggt gag aac cca gaa gaa     1219
 Leu Gly Leu Ala Glu Leu Leu Arg Val Ala Gly Glu Asn Pro Glu Glu
 355                 360                 365                 370

 agg cgg gga cag gtt cta atc ctt tta gtg gag cag gca ctt cgc ttc     1267
 Arg Arg Gly Gln Val Leu Ile Leu Leu Val Glu Gln Ala Leu Arg Phe
                 375                 380                 385

 cat gac tac aaa gca gcc agt atg cat tgt cag gag ctg atg gcc aca     1315
 His Asp Tyr Lys Ala Ala Ser Met His Cys Gln Glu Leu Met Ala Thr
             390                 395                 400

 ggt tat cct aaa agt tgg gat gtt tgt agc cag tta gga caa tca gaa     1363
 Gly Tyr Pro Lys Ser Trp Asp Val Cys Ser Gln Leu Gly Gln Ser Glu
         405                 410                 415

 ggt tac cag gac ttg gcc act cgt caa gag ctc atg gct ttt gct ttg     1411
 Gly Tyr Gln Asp Leu Ala Thr Arg Gln Glu Leu Met Ala Phe Ala Leu
     420                 425                 430

 aca cat tgc cct cct agc agc att gaa ctt ctt ttg gca gct agc agc     1459
 Thr His Cys Pro Pro Ser Ser Ile Glu Leu Leu Leu Ala Ala Ser Ser
 435                 440                 445                 450

 tct ctg cag aca gaa att ctt tat caa aga gtg aat ttc cag atc cat     1507
 Ser Leu Gln Thr Glu Ile Leu Tyr Gln Arg Val Asn Phe Gln Ile His
                 455                 460                 465

 cat gaa gga ggg gaa aat atc agt gct tca cca tta act agt aaa gca     1555
 His Glu Gly Gly Glu Asn Ile Ser Ala Ser Pro Leu Thr Ser Lys Ala
             470                 475                 480

 gta caa gag gat gaa gta ggt gtt cca ggt agc aat tca gct gac cta     1603
 Val Gln Glu Asp Glu Val Gly Val Pro Gly Ser Asn Ser Ala Asp Leu
         485                 490                 495

 ttg cgc tgg acc act gct acc acc atg aaa gtc ctt tcc aac acc aca     1651
 Leu Arg Trp Thr Thr Ala Thr Thr Met Lys Val Leu Ser Asn Thr Thr
     500                 505                 510

 acc acc acc aaa gcg gtg ctg cag gcc gtc agt gat ggg cag tgg tgg     1699
 Thr Thr Thr Lys Ala Val Leu Gln Ala Val Ser Asp Gly Gln Trp Trp
 515                 520                 525                 530

 aag aag tct tta act tac ctt cga ccc ctt cag ggg caa aaa tgt ggt     1747
 Lys Lys Ser Leu Thr Tyr Leu Arg Pro Leu Gln Gly Gln Lys Cys Gly
                 535                 540                 545

 ggt gca tat caa atc gga act aca gcc aat gaa gat cta gag aaa caa     1795
 Gly Ala Tyr Gln Ile Gly Thr Thr Ala Asn Glu Asp Leu Glu Lys Gln
             550                 555                 560

 ggg tgt cat cct ttt tat gaa tct gtc atc tca aat cct ttt gtc gct     1843
 Gly Cys His Pro Phe Tyr Glu Ser Val Ile Ser Asn Pro Phe Val Ala
         565                 570                 575

 gag tct gaa ggg acc tat gac acc tat cag cat gtt cca gtg gaa agc     1891
 Glu Ser Glu Gly Thr Tyr Asp Thr Tyr Gln His Val Pro Val Glu Ser
     580                 585                 590

 ttt gca gaa gta ttg ctg aga act gga aaa ttg gca gag gct aaa aat     1939
 Phe Ala Glu Val Leu Leu Arg Thr Gly Lys Leu Ala Glu Ala Lys Asn
 595                 600                 605                 610

 aaa gga gaa gta ttt cca aca act gaa gtt ctc ttg caa cta gca agt     1987
 Lys Gly Glu Val Phe Pro Thr Thr Glu Val Leu Leu Gln Leu Ala Ser
                 615                 620                 625

 gaa gcc ttg cca aat gac atg acc ttg gct ctt gct tac ctt ctt gcc     2035
 Glu Ala Leu Pro Asn Asp Met Thr Leu Ala Leu Ala Tyr Leu Leu Ala
             630                 635                 640

 tta cca caa gtg tta gat gct aac cgg tgc ttt gaa aag cag tcc ccc     2083
 Leu Pro Gln Val Leu Asp Ala Asn Arg Cys Phe Glu Lys Gln Ser Pro
         645                 650                 655

 tct gca tta tct ctc cag ctg gca gcg tat tac tat agc ctc cag atc     2131
 Ser Ala Leu Ser Leu Gln Leu Ala Ala Tyr Tyr Tyr Ser Leu Gln Ile
     660                 665                 670

 tat gcc cga ttg gcc cca tgt ttc agg gac aag tgc cat cct ctt tac     2179
 Tyr Ala Arg Leu Ala Pro Cys Phe Arg Asp Lys Cys His Pro Leu Tyr
 675                 680                 685                 690

 agg gct gat ccc aaa gaa cta atc aag atg gtc acc agg cat gtg act     2227
 Arg Ala Asp Pro Lys Glu Leu Ile Lys Met Val Thr Arg His Val Thr
                 695                 700                 705

 cga cat gag cac gaa gcc tgg cct gaa gac ctt att tca ctg acc aag     2275
 Arg His Glu His Glu Ala Trp Pro Glu Asp Leu Ile Ser Leu Thr Lys
             710                 715                 720

 cag tta cac tgc tac aat gaa cgt ctc ctg gat ttc act cag gcg cag     2323
 Gln Leu His Cys Tyr Asn Glu Arg Leu Leu Asp Phe Thr Gln Ala Gln
         725                 730                 735

 atc ctt cag ggc ctt cgg aag ggt gtg gac gtg cag cgg ttt act gca     2371
 Ile Leu Gln Gly Leu Arg Lys Gly Val Asp Val Gln Arg Phe Thr Ala
     740                 745                 750

 gat gac cag tat aaa agg gaa act atc ctt ggt ctg gca gaa act cta     2419
 Asp Asp Gln Tyr Lys Arg Glu Thr Ile Leu Gly Leu Ala Glu Thr Leu
 755                 760                 765                 770

 gag gaa agc gtc tac agc att gct att tct ctg gca caa cgt tac agt     2467
 Glu Glu Ser Val Tyr Ser Ile Ala Ile Ser Leu Ala Gln Arg Tyr Ser
                 775                 780                 785

 gtc tcc cgc tgg gaa gtt ttt atg acc cat ttg gag ttc ctc ttc acg     2515
 Val Ser Arg Trp Glu Val Phe Met Thr His Leu Glu Phe Leu Phe Thr
             790                 795                 800

 gac agt ggt ttg tcc aca cta gaa att gaa aat aga gcc caa gac ctt     2563
 Asp Ser Gly Leu Ser Thr Leu Glu Ile Glu Asn Arg Ala Gln Asp Leu
         805                 810                 815

 cat ctc ttt gag act ttg aag act gat cca gaa gcc ttt cac cag cac     2611
 His Leu Phe Glu Thr Leu Lys Thr Asp Pro Glu Ala Phe His Gln His
     820                 825                 830

 atg gtc aag tat att tac cct act att ggt ggc ttt gat cac gaa agg     2659
 Met Val Lys Tyr Ile Tyr Pro Thr Ile Gly Gly Phe Asp His Glu Arg
 835                 840                 845                 850

 ctg cag tat tat ttc act ctt ctg gaa aac tgt ggc tgt gca gat ttg     2707
 Leu Gln Tyr Tyr Phe Thr Leu Leu Glu Asn Cys Gly Cys Ala Asp Leu
                 855                 860                 865

 ggg aac tgt gcc att aaa cca gaa acc cac att cga ctg ctg aag aag     2755
 Gly Asn Cys Ala Ile Lys Pro Glu Thr His Ile Arg Leu Leu Lys Lys
             870                 875                 880

 ttt aag gtt gtt gca tca ggt ctt aat tac aaa aag ctg aca gat gaa     2803
 Phe Lys Val Val Ala Ser Gly Leu Asn Tyr Lys Lys Leu Thr Asp Glu
         885                 890                 895

 aac atg agt cct ctt gaa gca ttg gag cca gtt ctt tca agt caa aat     2851
 Asn Met Ser Pro Leu Glu Ala Leu Glu Pro Val Leu Ser Ser Gln Asn
     900                 905                 910

 atc ttg tct att tcc aaa ctt gtt ccc aaa atc cct gaa aag gat gga     2899
 Ile Leu Ser Ile Ser Lys Leu Val Pro Lys Ile Pro Glu Lys Asp Gly
 915                 920                 925                 930

 cag atg ctt tcc cca agc tct ctg tac acc atc tgg tta cag aag ttg     2947
 Gln Met Leu Ser Pro Ser Ser Leu Tyr Thr Ile Trp Leu Gln Lys Leu
                 935                 940                 945

 ttc tgg act gga gac cct cat ctc att aaa caa gtc cca ggc tct tca     2995
 Phe Trp Thr Gly Asp Pro His Leu Ile Lys Gln Val Pro Gly Ser Ser
             950                 955                 960

 ccg gag tgg ctt cat gcc tat gat gtc tgc atg aag tac ttt gat cgt     3043
 Pro Glu Trp Leu His Ala Tyr Asp Val Cys Met Lys Tyr Phe Asp Arg
         965                 970                 975

 ctc cac cca ggt gac ctc atc act gtg gta gat gca gtt aca ttt tct     3091
 Leu His Pro Gly Asp Leu Ile Thr Val Val Asp Ala Val Thr Phe Ser
     980                 985                 990

 cca aaa gct gtg acc aag ctg tct gtg gaa gcc cgt aaa gag atg act     3139
 Pro Lys Ala Val Thr Lys Leu Ser Val Glu Ala Arg Lys Glu Met Thr
 995                1000                1005                1010

 aga aag gct att aag aca gtc aaa cat ttt att gag aag cca agg aaa     3187
 Arg Lys Ala Ile Lys Thr Val Lys His Phe Ile Glu Lys Pro Arg Lys
                1015                1020                1025

 aga aac tca gaa gac gaa gct caa gaa gct aag gat tct aaa gtt acc     3235
 Arg Asn Ser Glu Asp Glu Ala Gln Glu Ala Lys Asp Ser Lys Val Thr
            1030                1035                1040

 tat gca gat act ttg aat cat ctg gag aaa tca ctt gcc cac ctg gaa     3283
 Tyr Ala Asp Thr Leu Asn His Leu Glu Lys Ser Leu Ala His Leu Glu
        1045                1050                1055

 acc ctg agc cac agc ttc atc ctt tct ctg aag aat agt gag cag gaa     3331
 Thr Leu Ser His Ser Phe Ile Leu Ser Leu Lys Asn Ser Glu Gln Glu
    1060                1065                1070

 aca ctg caa aaa tac agt cac ctc tat gat ctg tcc cga tca gaa aaa     3379
 Thr Leu Gln Lys Tyr Ser His Leu Tyr Asp Leu Ser Arg Ser Glu Lys
1075                1080                1085                1090

 gag aaa ctt cat gat gaa gct gtg gct att tgt tta gat ggt cag cct     3427
 Glu Lys Leu His Asp Glu Ala Val Ala Ile Cys Leu Asp Gly Gln Pro
                1095                1100                1105

 cta gca atg att cag cag ctg cta gag gtg gca gtt ggc cct ctt gac     3475
 Leu Ala Met Ile Gln Gln Leu Leu Glu Val Ala Val Gly Pro Leu Asp
            1110                1115                1120

 atc tca ccc aag gat ata gtg cag agt gca atc atg aaa ata att tct     3523
 Ile Ser Pro Lys Asp Ile Val Gln Ser Ala Ile Met Lys Ile Ile Ser
        1125                1130                1135

 gca ttg agt ggt ggc agt gct gac ctt ggt ggg cca agg gac cca ctg     3571
 Ala Leu Ser Gly Gly Ser Ala Asp Leu Gly Gly Pro Arg Asp Pro Leu
    1140                1145                1150

 aag gtc ctg gaa ggt gtt gtt gca gca gtc cac gcc agt gtg gac aag     3619
 Lys Val Leu Glu Gly Val Val Ala Ala Val His Ala Ser Val Asp Lys
1155                1160                1165                1170

 ggt gag gag ctg gtt tca cct gag gac ctg ctg gag tgg ctg cgg cct     3667
 Gly Glu Glu Leu Val Ser Pro Glu Asp Leu Leu Glu Trp Leu Arg Pro
                1175                1180                1185

 ttc tgt gct gat gac gcc tgg ccg gtg cgg ccc cgc att cac gtg ctg     3715
 Phe Cys Ala Asp Asp Ala Trp Pro Val Arg Pro Arg Ile His Val Leu
            1190                1195                1200

 cag att ttg ggg caa tca ttt cac ctg act gag gag gac agc aag ctc     3763
 Gln Ile Leu Gly Gln Ser Phe His Leu Thr Glu Glu Asp Ser Lys Leu
        1205                1210                1215

 ctc gtg ttc ttt aga act gaa gcc att ctc aaa gcc tcc tgg ccc cag     3811
 Leu Val Phe Phe Arg Thr Glu Ala Ile Leu Lys Ala Ser Trp Pro Gln
    1220                1225                1230

 aga cag gta gac ata gct gac att gag aat gaa gag aac cgc tac tgt     3859
 Arg Gln Val Asp Ile Ala Asp Ile Glu Asn Glu Glu Asn Arg Tyr Cys
1235                1240                1245                1250

 cta ttc atg gaa ctc ctg gaa tct agt cac cac gag gct gaa ttt cag     3907
 Leu Phe Met Glu Leu Leu Glu Ser Ser His His Glu Ala Glu Phe Gln
                1255                1260                1265

 cac ttg gtt tta ctt ttg caa gct tgg cca cct atg aaa agt gaa tat     3955
 His Leu Val Leu Leu Leu Gln Ala Trp Pro Pro Met Lys Ser Glu Tyr
            1270                1275                1280

 gtc ata acc aat aat cca tgg gtg aga cta gct aca gtg atg cta acc     4003
 Val Ile Thr Asn Asn Pro Trp Val Arg Leu Ala Thr Val Met Leu Thr
        1285                1290                1295

 aga tgt acg atg gag aac aag gaa gga ttg ggg aat gaa gtt ttg aaa     4051
 Arg Cys Thr Met Glu Asn Lys Glu Gly Leu Gly Asn Glu Val Leu Lys
    1300                1305                1310

 atg tgt cgc tct ttg tat aac acc aag cag atg ctg cct gca gag gtg     4099
 Met Cys Arg Ser Leu Tyr Asn Thr Lys Gln Met Leu Pro Ala Glu Val
1315                1320                1325                1330

 aat gat tcc aat tgt gac caa gaa ctt ctt tcc ctg ctc ctg gat gcc     4147
 Asn Asp Ser Asn Cys Asp Gln Glu Leu Leu Ser Leu Leu Leu Asp Ala
                1335                1340                1345

 aag ctg ctg gtg aag tgt gtc tcc act ccc ttc tat cca cgt att gtt     4195
 Lys Leu Leu Val Lys Cys Val Ser Thr Pro Phe Tyr Pro Arg Ile Val
            1350                1355                1360

 gac cac ctc ttg gct agc ctc cag caa ggg cgc tgg gat gca gag gag     4243
 Asp His Leu Leu Ala Ser Leu Gln Gln Gly Arg Trp Asp Ala Glu Glu
        1365                1370                1375

 ctg ggc aga cac ctg cgg gag gcc ggc cat gaa gcc gaa gcc ggg tct     4291
 Leu Gly Arg His Leu Arg Glu Ala Gly His Glu Ala Glu Ala Gly Ser
    1380                1385                1390

 ctc ctt ctg gcc gtg agg ggg act cac cag gcc ttc aga acc ttc agt     4339
 Leu Leu Leu Ala Val Arg Gly Thr His Gln Ala Phe Arg Thr Phe Ser
1395                1400                1405                1410

 aca gcc ctc cgc gca gca cag cac tgg gtg tga gggccacc tgtggccctg     4390
 Thr Ala Leu Arg Ala Ala Gln His Trp Val 
                1415                1420

 ctccttagca gaaaaagcat ctggagttga atgctgttcc cagaagcaac atgtgtatct   4450

 gccgattgtt ctccatggtt ccaacaaatt gcaaataaaa ctgtatggaa acgaaaaaaa   4510

 atatcggcct cgtggcctca cggagtagct ctggagcgct tctttaagaa gggaataatg   4570

 accagcgtat gactcatgac ctgtggtagg cggaggagcg gtcagttcct taaggcggtc   4630

 ggttaccaag aatggatact ggaaaactgc gcatgccacg cgtaacaaag cttgtttt     4688




      <210> 204
      <211> 1086
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1086)

      <400> 204
  atg gct cag cgg tgc gtt tgc gtg ctg gcc ctg gtg gct atg ctg ctc      48
  Met Ala Gln Arg Cys Val Cys Val Leu Ala Leu Val Ala Met Leu Leu
    1               5                  10                  15

 cta gtt ttc cct acc gtc tcc aga tcg atg ggc ccg agg agc ggg gag       96
 Leu Val Phe Pro Thr Val Ser Arg Ser Met Gly Pro Arg Ser Gly Glu
              20                  25                  30

 cat caa agg gcg tcg cga atc cct tct cag ttc agc aaa gag gaa cgc      144
 His Gln Arg Ala Ser Arg Ile Pro Ser Gln Phe Ser Lys Glu Glu Arg
          35                  40                  45

 gtc gcg atg aaa gag gcg ctg aaa ggt gcc atc cag att cca aca gtg      192
 Val Ala Met Lys Glu Ala Leu Lys Gly Ala Ile Gln Ile Pro Thr Val
      50                  55                  60

 act ttt agc tct gag aag tcc aat act aca gcc ctg gct gag ttc gga      240
 Thr Phe Ser Ser Glu Lys Ser Asn Thr Thr Ala Leu Ala Glu Phe Gly
  65                  70                  75                  80

 aaa tac att cat aaa gtc ttt cct aca gtg gtc agc acc agc ttt atc      288
 Lys Tyr Ile His Lys Val Phe Pro Thr Val Val Ser Thr Ser Phe Ile
                  85                  90                  95

 cag cat gaa gtc gtg gaa gag tat agc cac ctg ttc act atc caa ggc      336
 Gln His Glu Val Val Glu Glu Tyr Ser His Leu Phe Thr Ile Gln Gly
             100                 105                 110

 tcg gac ccc agc ttg cag ccc tac ctg ctg atg gct cac ttt gat gtg      384
 Ser Asp Pro Ser Leu Gln Pro Tyr Leu Leu Met Ala His Phe Asp Val
         115                 120                 125

 gtg cct gcc cct gaa gaa ggc tgg gag gtg ccc cca ttc tct ggg ttg      432
 Val Pro Ala Pro Glu Glu Gly Trp Glu Val Pro Pro Phe Ser Gly Leu
     130                 135                 140

 gag cgt gat ggc gtc atc tat ggt tgg ggc aca ctg gac gac aag aac      480
 Glu Arg Asp Gly Val Ile Tyr Gly Trp Gly Thr Leu Asp Asp Lys Asn
 145                 150                 155                 160

 tct gtg atg gca tta ctg cag gcc ttg gag ctc ctg ctg atc agg aag      528
 Ser Val Met Ala Leu Leu Gln Ala Leu Glu Leu Leu Leu Ile Arg Lys
                 165                 170                 175

 tac atc ccc cga aga tct ttc ttc att tct ctg ggc cat gat gag gag      576
 Tyr Ile Pro Arg Arg Ser Phe Phe Ile Ser Leu Gly His Asp Glu Glu
             180                 185                 190

 tca tca ggg aca ggg gct cag agg atc tca gcc ctg cta cag tca agg      624
 Ser Ser Gly Thr Gly Ala Gln Arg Ile Ser Ala Leu Leu Gln Ser Arg
         195                 200                 205

 ggc gtc cag cta gcc ttc att gtg gac gag ggg ggc ttc atc ttg gat      672
 Gly Val Gln Leu Ala Phe Ile Val Asp Glu Gly Gly Phe Ile Leu Asp
     210                 215                 220

 gat ttc att cct aac ttc aag aag ccc atc gcc ttg att gca gtc tca      720
 Asp Phe Ile Pro Asn Phe Lys Lys Pro Ile Ala Leu Ile Ala Val Ser
 225                 230                 235                 240

 gag aag ggt tcc atg aac ctc atg ctg caa gta aac atg act tca ggc      768
 Glu Lys Gly Ser Met Asn Leu Met Leu Gln Val Asn Met Thr Ser Gly
                 245                 250                 255

 cac tct tca gct cct cca aag gag aca agc att ggc atc ctt gca gct      816
 His Ser Ser Ala Pro Pro Lys Glu Thr Ser Ile Gly Ile Leu Ala Ala
             260                 265                 270

 gct gtc agc cga ttg gag cag aca cca atg cct atc ata ttt gga agc      864
 Ala Val Ser Arg Leu Glu Gln Thr Pro Met Pro Ile Ile Phe Gly Ser
         275                 280                 285

 ggg aca gtg gtg act gta ttg cag caa ctg gca aat gag gtt tat gga      912
 Gly Thr Val Val Thr Val Leu Gln Gln Leu Ala Asn Glu Val Tyr Gly
     290                 295                 300

 gag aaa tcc ctt aac caa tgc aat aat cag gac cac cac ggc act cac      960
 Glu Lys Ser Leu Asn Gln Cys Asn Asn Gln Asp His His Gly Thr His
 305                 310                 315                 320

 cat att caa agc agg ggt caa gtt caa tgt cat ccc ccc agt ggc cca     1008
 His Ile Gln Ser Arg Gly Gln Val Gln Cys His Pro Pro Ser Gly Pro
                 325                 330                 335

 ggc cac agt caa ctt ccg gat tca ccc tgg aca gac agt cca aga ggt     1056
 Gly His Ser Gln Leu Pro Asp Ser Pro Trp Thr Asp Ser Pro Arg Gly
             340                 345                 350

 cct aga act cac gaa gaa cat tgt ggc tga                             1086
 Pro Arg Thr His Glu Glu His Cys Gly 
         355                 360





      <210> 205
      <211> 1566
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (123)..(1220)

      <220>
      <221> misc_feature
      <222> (1)...(1566)
      <223> n = a,t,c or g

      <400> 205
 gggcgccagt tgcgnaagca catccggtnn nctggccgta ccgactggga aaacagctga     60

 ccttggggct ggtgggcccc ttttgagtag gaggggctgc tgcaggctcc tccacaggcg    120

 tc   atg gcc ctc cga ttc ctc ttg ggc ttt ctg ctt gcc ggt gtt gac     167
      Met Ala Leu Arg Phe Leu Leu Gly Phe Leu Leu Ala Gly Val Asp
        1               5                  10                  15

 ctg ggt gtc tac ctg atg cgc ctg gag ctg tgc gac cca acc cag agg      215
 Leu Gly Val Tyr Leu Met Arg Leu Glu Leu Cys Asp Pro Thr Gln Arg
                  20                  25                  30

 ctt cgg gtg gcc ctg gca ggg gag ttg gtg ggg gtg gga ggg cac ttc      263
 Leu Arg Val Ala Leu Ala Gly Glu Leu Val Gly Val Gly Gly His Phe
              35                  40                  45

 ctg ttc ctg ggc ctg gcc ctt gtc tct aag gat tgg cga ttc cta cag      311
 Leu Phe Leu Gly Leu Ala Leu Val Ser Lys Asp Trp Arg Phe Leu Gln
          50                  55                  60

 cga atg atc acc gct ccc tgc atc ctc ttc ctg ttt tat ggc tgg cct      359
 Arg Met Ile Thr Ala Pro Cys Ile Leu Phe Leu Phe Tyr Gly Trp Pro
      65                  70                  75

 ggt ttg ttc ctg gag tcc gca cgg tgg ctg ata gtg aag cgg cag att      407
 Gly Leu Phe Leu Glu Ser Ala Arg Trp Leu Ile Val Lys Arg Gln Ile
  80                  85                  90                  95

 gag gag gct cag tct gtg ctg agg atc ctg gct gag cga aac cgg ccc      455
 Glu Glu Ala Gln Ser Val Leu Arg Ile Leu Ala Glu Arg Asn Arg Pro
                 100                 105                 110

 cat ggg cag atg ctg ggg gag gag gcc cag gag gcc ctg cag gac ctg      503
 His Gly Gln Met Leu Gly Glu Glu Ala Gln Glu Ala Leu Gln Asp Leu
             115                 120                 125

 gag aat acc tgc cct ctc cct gca aca tcc tcc ttt tcc ttt gct tcc      551
 Glu Asn Thr Cys Pro Leu Pro Ala Thr Ser Ser Phe Ser Phe Ala Ser
         130                 135                 140

 ctc ctc aac tac cgc aac atc tgg aaa aat ctg ctt atc ctg ggc ttc      599
 Leu Leu Asn Tyr Arg Asn Ile Trp Lys Asn Leu Leu Ile Leu Gly Phe
     145                 150                 155

 acc aac ttc att gcc cat gcc att cgc cac tgc tac cag cct gtg gga      647
 Thr Asn Phe Ile Ala His Ala Ile Arg His Cys Tyr Gln Pro Val Gly
 160                 165                 170                 175

 gga gga ggg agc cca tcg gac ttc tac ctg tgc tct ctg ctg gcc agc      695
 Gly Gly Gly Ser Pro Ser Asp Phe Tyr Leu Cys Ser Leu Leu Ala Ser
                 180                 185                 190

 ggc acc gca gcc ctg gcc tgt gtc ttc ctg ggg gtc acc gtg gac cga      743
 Gly Thr Ala Ala Leu Ala Cys Val Phe Leu Gly Val Thr Val Asp Arg
             195                 200                 205

 ttt ggc cgc cgg ggc atc ctt ctt ctc tcc atg acc ctt acc ggc att      791
 Phe Gly Arg Arg Gly Ile Leu Leu Leu Ser Met Thr Leu Thr Gly Ile
         210                 215                 220

 gct tcc ctg gtc ctg ctg ggc ctg tgg gat ctg aac gag gct gcc atc      839
 Ala Ser Leu Val Leu Leu Gly Leu Trp Asp Leu Asn Glu Ala Ala Ile
     225                 230                 235

 acc act ttc tct gtc ctt ggg ctc ttc tcc tcc caa gct gcc gcc atc      887
 Thr Thr Phe Ser Val Leu Gly Leu Phe Ser Ser Gln Ala Ala Ala Ile
 240                 245                 250                 255

 ctc agc acc ctc ctt gct gct gag gtc atc ccc acc act gtc cgg ggc      935
 Leu Ser Thr Leu Leu Ala Ala Glu Val Ile Pro Thr Thr Val Arg Gly
                 260                 265                 270

 cgt ggc ctg ggc ctg atc atg gct cta ggg gcg ctt gga gga ctg agc      983
 Arg Gly Leu Gly Leu Ile Met Ala Leu Gly Ala Leu Gly Gly Leu Ser
             275                 280                 285

 ggc ccg gcc cag cgc ctc cac atg ggc cat gga gcc ttc ctg cag cac     1031
 Gly Pro Ala Gln Arg Leu His Met Gly His Gly Ala Phe Leu Gln His
         290                 295                 300

 gtg gtg ctg gcg gcc tgc gcc ctc ctc tgc att ctc agc att atg ctg     1079
 Val Val Leu Ala Ala Cys Ala Leu Leu Cys Ile Leu Ser Ile Met Leu
     305                 310                 315

 ctg ccg gag acc aag cgc aag ctc ctg ccc gag gtg ctc cgg gac ggg     1127
 Leu Pro Glu Thr Lys Arg Lys Leu Leu Pro Glu Val Leu Arg Asp Gly
 320                 325                 330                 335

 gag ctg tgt cgc cgg cct tcc ctg ctg cgg cag cca ccc cct acc cgc     1175
 Glu Leu Cys Arg Arg Pro Ser Leu Leu Arg Gln Pro Pro Pro Thr Arg
                 340                 345                 350

 tgt gac cac gtc ccg ctg ctt gcc acc ccc aac cct gcc ctc tga gcg     1223
 Cys Asp His Val Pro Leu Leu Ala Thr Pro Asn Pro Ala Leu 
             355                 360                 365

 gcctctgagt accctggcgg gaggctggcc cacacagaaa ggtggcaaga agatcgggaa   1283

 gactgagtag ggaaggcagg gctgcccaga agtctcagag gcacctcacg ccagccatcg   1343

 cggagagctc agagggccgt ccccaccctg cctcctccct gctgctttgc attcacttcc   1403

 ttggccagag tcaggggaca gggagagagc tccacactgt aaccactggg tctgggctcc   1463

 atcctgcgcc caaagacatc cacccagacc tcattatttc ttgctctatc attctgtttc   1523

 aataaagaca tttggaataa acgagcatat cataaaaaaa aaa                     1566




      <210> 206
      <211> 2233
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(604)

      <400> 206
 ggaggaaaac gacctggtgc agactccgcg gggcctgagt gatctggaga taggg atg      58
                                                              Met
                                                                1

 tac gcc ctc ctg ggg gtg ttc tgc ctg gcc atc ctc gtc ttc ctg atc      106
 Tyr Ala Leu Leu Gly Val Phe Cys Leu Ala Ile Leu Val Phe Leu Ile
               5                  10                  15

 aac tgc gcc acc ttt gcc ctg aag tac agg cac aag caa gtg ccc ctg      154
 Asn Cys Ala Thr Phe Ala Leu Lys Tyr Arg His Lys Gln Val Pro Leu
          20                  25                  30

 gaa ggt cag gcc tcc atg acc cac tct cac gac tgg gtg tgg ctt ggc      202
 Glu Gly Gln Ala Ser Met Thr His Ser His Asp Trp Val Trp Leu Gly
      35                  40                  45

 aat gag gcc gaa ctc ctg gag agc atg ggg gat gcg ccg ccg ccc cag      250
 Asn Glu Ala Glu Leu Leu Glu Ser Met Gly Asp Ala Pro Pro Pro Gln
  50                  55                  60                  65

 gac gag cac acc acc atc ata gac cgc gga ccg ggg gcc tgc gag gag      298
 Asp Glu His Thr Thr Ile Ile Asp Arg Gly Pro Gly Ala Cys Glu Glu
                  70                  75                  80

 agc aac cat ctc ctg ctc aat ggt ggc tcc cac aag cac gtg cag agc      346
 Ser Asn His Leu Leu Leu Asn Gly Gly Ser His Lys His Val Gln Ser
              85                  90                  95

 cag att cac agg tca gcc gac tcc ggg ggg cgg cag ggc aga gaa cag      394
 Gln Ile His Arg Ser Ala Asp Ser Gly Gly Arg Gln Gly Arg Glu Gln
         100                 105                 110

 aag cag gac ccc ctg cac tcg ccc acc tcc aag agg aag aag gtg aaa      442
 Lys Gln Asp Pro Leu His Ser Pro Thr Ser Lys Arg Lys Lys Val Lys
     115                 120                 125

 ttt acc acc ttt acc acc atc ccc ccg gac gac agc tgc ccc acg gtg      490
 Phe Thr Thr Phe Thr Thr Ile Pro Pro Asp Asp Ser Cys Pro Thr Val
 130                 135                 140                 145

 aac tcc atc gtc agc agc aat gat gag gac atc aaa tgg gtg tgt caa      538
 Asn Ser Ile Val Ser Ser Asn Asp Glu Asp Ile Lys Trp Val Cys Gln
                 150                 155                 160

 gac gtg gct gtg ggt gcc ccc aag gaa ctt aga aac tat ctg gag aaa      586
 Asp Val Ala Val Gly Ala Pro Lys Glu Leu Arg Asn Tyr Leu Glu Lys
             165                 170                 175

 ctc aaa gat aag gct tag gcccct ctagccaaag ggccctgccc agatgccttc      640
 Leu Lys Asp Lys Ala 
         180

 cttgtactgg aaactggccc aagtggggca gaaggcgttg tcagtggggt taagaaggga    700

 cggtcccagg gtccatgcta gaccagttgg aaagttttga agtcaggaaa agacgttttt    760

 gtatcaaggg atttttagca gttaatggtg gtggattttt aaaggtcagg ggaataaagt    820

 ctggggcatg gggagtgcag accaagttac tgaactgcac aggcaaaatt aggaaggtta    880

 ttttatgagt caaaacatac tacagacaag ctaccaaaaa ttatttgtta aaaaatgcaa    940

 caagacaaat aaaaagagaa ataatcatct gtttatattt ctaataaagg agcaaaatat   1000

 aaaaatagga cctgctaaga gacattttcc attctaattc acgattcact tttccaagga   1060

 cagccttcaa ctgtcaccac acagctgggg gggagtcatt tcttaacaag ggatgcctct   1120

 tgggatagaa ctagggagtt ttaaatcttt acttgatcat cttttatttt cttttccact   1180

 ttttcctttt ctctctctct ctgtgtccta gacttccatt gcatttatat ttaatgttta   1240

 tttctgagaa tcaagcagta tatttttcct aaatgaaaca taaattatat tcctattcat   1300

 tagataggtt cctaggaaca atgccaatta atccattgtt taagtagtaa cttgaatgtt   1360

 tttctatatc cctccagctt tgttgatagt ggcgggtttt gtacaattgg agggagccct   1420

 cagagccttc tgggggagga gaggaactgt ccttaatcca tcaccactac catagggcaa   1480

 agccagcagg tgtggccctg tgaggggctg tacagacggg atgtggccag gagaacagag   1540

 ccccacctgg accacctgac ccctcgggat tccacccctg tcatcgtggg gatgttccta   1600

 tataggagaa agttgggtta aatcaaaaaa gaggccacgc ccaggtgtaa tcagagccaa   1660

 cctggtgggc tgggtctatc acaagacata actgatgctg aacatgaaca aagataaaaa   1720

 ctgtttggag ggtttttgag ttgtttttct tatgttgttg ggtggggtat accagcataa   1780

 actctaaaga taaaatctat gttagattgt caatcaactg tgtttttgaa cagcataatt   1840

 gtgtagcagc acattgcaaa aatgcattca tccaaagcga cacatgtggc aacgtagacc   1900

 acgccagtga aataagcccc ttcgtgatca cctgactcca gttctccgtg tgctccattg   1960

 gctgcggctg caggaggaag atgcctgaca gccctcatgc tctccgcagg ggggcgctca   2020

 caaagatgcc aggggtgttt attgtgttta tttttttaat tactaaaatc agtagctaag   2080

 aaagggtcct tgaagcctcc taacctgggt tggacctttg aaaaatatat ttgtagcaca   2140

 tattatagat ggaaagaaga agatatttat ttatacctgt gatgccaatt gtcattaaaa   2200

 ggcttttcat ggcttgacaa gtcaaaaaaa aaa                                2233




      <210> 207
      <211> 915
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (214)..(777)

      <400> 207
 tcggctgggc gtgcgctcgc tccccgaagc cggggctggg ccggatgccg ggcgagggct     60

 gggagctggg ccgggtccgg ggacagcggg cgaggggcag ctgccggagc cgggcagcca    120

 ggccgctcag ggcaggggac agctggcgcc tggttctgct ggtctccggg gcccagatgt    180

 gaggcggcgg cgcccccggc ccgagagcgc acg atg ggg gcc ccg ctc gcc gta     234
                                      Met Gly Ala Pro Leu Ala Val
                                        1               5

 gcg ctg ggc gcc ctc cac tac ctg gca ctt ttc ctg caa ctc ggc ggc      282
 Ala Leu Gly Ala Leu His Tyr Leu Ala Leu Phe Leu Gln Leu Gly Gly
          10                  15                  20

 gcc acg cgg ccc gcc ggc cac gcg ccc tgg gac aac cac gtc tcc ggc      330
 Ala Thr Arg Pro Ala Gly His Ala Pro Trp Asp Asn His Val Ser Gly
      25                  30                  35

 cac gcc ctg ttc aca gag aca ccc cat gac atg aca gca cgg acg ggc      378
 His Ala Leu Phe Thr Glu Thr Pro His Asp Met Thr Ala Arg Thr Gly
  40                  45                  50                  55

 gag gac gtg gag atg gcc tgc tcc ttc cgc ggc agc ggc tcc ccc tcc      426
 Glu Asp Val Glu Met Ala Cys Ser Phe Arg Gly Ser Gly Ser Pro Ser
                  60                  65                  70

 tac tcg ctg gag atc cag tgg tgg tat gta cgg agc cac cgg gac tgg      474
 Tyr Ser Leu Glu Ile Gln Trp Trp Tyr Val Arg Ser His Arg Asp Trp
              75                  80                  85

 acc gac aag cag gcg tgg gcc tcg aac cag gtg gtc aag gtg gtg ggc      522
 Thr Asp Lys Gln Ala Trp Ala Ser Asn Gln Val Val Lys Val Val Gly
          90                  95                 100

 agc aac atc tcc cac aag ctg cgc ctg tcc cgg gtg aag ccc acg gac      570
 Ser Asn Ile Ser His Lys Leu Arg Leu Ser Arg Val Lys Pro Thr Asp
     105                 110                 115

 gaa ggc acc tac gag tgc cgc gtc atc gac ttc agc gac ggc aag gcc      618
 Glu Gly Thr Tyr Glu Cys Arg Val Ile Asp Phe Ser Asp Gly Lys Ala
 120                 125                 130                 135

 cgg cac cac aag gtc aag gcc tac ctg cgg gtg cag cca ggg gag aac      666
 Arg His His Lys Val Lys Ala Tyr Leu Arg Val Gln Pro Gly Glu Asn
                 140                 145                 150

 tcc gtc ctg cat ctg ccc gaa gcc cct ccc gcc gcg ccc gcc ccg ccg      714
 Ser Val Leu His Leu Pro Glu Ala Pro Pro Ala Ala Pro Ala Pro Pro
             155                 160                 165

 ccc ccc aag cca ggt aag gag ctg agg aag cgc tcg gtg gac cag gag      762
 Pro Pro Lys Pro Gly Lys Glu Leu Arg Lys Arg Ser Val Asp Gln Glu
         170                 175                 180

 gcc tgc agc ctc tag actgatgccc ctgcccccgc ccatccgccc ccacgctgta      817
 Ala Cys Ser Leu 
     185

 cagagtgcat gaggagccgc cggaccaccg gggaccgact gcctgcgtcc agccgcgccc    877

 catccccgag gccgcctgtg ggcaccatgt cggccctc                            915




      <210> 208
      <211> 4325
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (223)..(3762)

      <400> 208
 attctttgga atactactgc tagaagtctg acttaagacc cagcttatgg gccacatggc     60

 acccagctgc ttctgcagag aaggcaggcc actgatgggt acagcaaagt gtggtgctgc    120

 tggccaagcc aaagacccgt gtaggatgac tgggcctctg ccccttgtgg gtgttgccac    180

 tgtgcttgag tgcctggtga agaatgtgat gggatcacta gc   atg tct gcg gag     234
                                                  Met Ser Ala Glu
                                                    1

 agc ggc cct ggg acg aga ttg aga aat ctg cca gta atg ggg gat gga      282
 Ser Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val Met Gly Asp Gly
   5                  10                  15                  20

 cta gaa act tcc caa atg tct aca aca cag gcc cag gcc caa ccc cag      330
 Leu Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln Ala Gln Pro Gln
                  25                  30                  35

 cca gcc aac gca gcc agc acc aac ccc ccg ccc cca gag acc tcc aac      378
 Pro Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro Glu Thr Ser Asn
              40                  45                  50

 cct aac aag ccc aag agg cag acc aac caa ctg caa tac ctg ctc aga      426
 Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln Tyr Leu Leu Arg
          55                  60                  65

 gtg gtg ctc aag aca cta tgg aaa cac cag ttt gca tgg cct ttc cag      474
 Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala Trp Pro Phe Gln
      70                  75                  80

 cag cct gtg gat gcc gtc aag ctg aac ctc cct gat tac tat aag atc      522
 Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp Tyr Tyr Lys Ile
  85                  90                  95                 100

 att aaa acg cct atg gat atg gga aca ata aag aag cgc ttg gaa aac      570
 Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn
                 105                 110                 115

 aac tat tac tgg aat gct cag gaa tgt atc cag gac ttc aac act atg      618
 Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp Phe Asn Thr Met
             120                 125                 130

 ttt aca aat tgt tac atc tac aac aag cct gga gat gac ata gtc tta      666
 Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp Asp Ile Val Leu
         135                 140                 145

 atg gca gaa gct ctg gaa aag ctc ttc ttg caa aaa ata aat gag cta      714
 Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys Ile Asn Glu Leu
     150                 155                 160

 ccc aca gaa gaa acc gag atc atg ata gtc cag gca aaa gga aga gga      762
 Pro Thr Glu Glu Thr Glu Ile Met Ile Val Gln Ala Lys Gly Arg Gly
 165                 170                 175                 180

 cgt ggg agg aaa gaa aca ggg aca gca aaa cct ggc gtt tcc acg gta      810
 Arg Gly Arg Lys Glu Thr Gly Thr Ala Lys Pro Gly Val Ser Thr Val
                 185                 190                 195

 cca aac aca act caa gca tcg act cct ccg cag acc cag acc cct cag      858
 Pro Asn Thr Thr Gln Ala Ser Thr Pro Pro Gln Thr Gln Thr Pro Gln
             200                 205                 210

 ccg aat cct cct cct gtg cag gcc acg cct cac ccc ttc cct gcc gtc      906
 Pro Asn Pro Pro Pro Val Gln Ala Thr Pro His Pro Phe Pro Ala Val
         215                 220                 225

 acc ccg gac ctc atc gtc cag acc cct gtc atg aca gtg gtg cct ccc      954
 Thr Pro Asp Leu Ile Val Gln Thr Pro Val Met Thr Val Val Pro Pro
     230                 235                 240

 cag cca ctg cag acg ccc ccg cca gtg ccc ccc cag cca caa ccc cca     1002
 Gln Pro Leu Gln Thr Pro Pro Pro Val Pro Pro Gln Pro Gln Pro Pro
 245                 250                 255                 260

 ccc gct cca gct ccc cag ccc gta cag agc cac cca ccc atc atc gcg     1050
 Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro Pro Ile Ile Ala
                 265                 270                 275

 gcc acc cca cag cct gtg aag aca aag aag gga gtg aag agg aaa gca     1098
 Ala Thr Pro Gln Pro Val Lys Thr Lys Lys Gly Val Lys Arg Lys Ala
             280                 285                 290

 gac acc acc acc ccc acc acc att gac ccc att cac gag cca ccc tcg     1146
 Asp Thr Thr Thr Pro Thr Thr Ile Asp Pro Ile His Glu Pro Pro Ser
         295                 300                 305

 ctg ccc ccg gag ccc aag acc acc aag ctg ggc cag cgg cgg gag agc     1194
 Leu Pro Pro Glu Pro Lys Thr Thr Lys Leu Gly Gln Arg Arg Glu Ser
     310                 315                 320

 agc cgg cct gtg aaa cct cca aag aag gac gtg ccc gac tct cag cag     1242
 Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro Asp Ser Gln Gln
 325                 330                 335                 340

 cac cca gca cca gag aag agc agc aag gtc tcg gag cag ctc aag tgc     1290
 His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu Gln Leu Lys Cys
                 345                 350                 355

 tgc agc ggc atc ctc aag gag atg ttt gcc aag aag cac gcc gcc tac     1338
 Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys His Ala Ala Tyr
             360                 365                 370

 gcc tgg ccc ttc tac aag cct gtg gac gtg gag gca ctg ggc cta cac     1386
 Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala Leu Gly Leu His
         375                 380                 385

 gac tac tgt gac atc atc aag cac ccc atg gac atg agc aca atc aag     1434
 Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met Ser Thr Ile Lys
     390                 395                 400

 tct aaa ctg gag gcc cgt gag tac cgt gat gct cag gag ttt ggt gct     1482
 Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln Glu Phe Gly Ala
 405                 410                 415                 420

 gac gtc cga ttg atg ttc tcc aac tgc tat aag tac aac cct cct gac     1530
 Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp
                 425                 430                 435

 cat gag gtg gtg gcc atg gcc cgc aag ctc cag gat gtg ttc gaa atg     1578
 His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp Val Phe Glu Met
             440                 445                 450

 cgc ttt gcc aag atg ccg gac gag cct gag gag cca gtg gtg gcc gtg     1626
 Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro Val Val Ala Val
         455                 460                 465

 tcc tcc ccg gca gtg ccc cct ccc acc aag gtt gtg gcc ccg ccc tca     1674
 Ser Ser Pro Ala Val Pro Pro Pro Thr Lys Val Val Ala Pro Pro Ser
     470                 475                 480

 tcc agc gac agc agc agc gat agc tcc tcg gac agt gac agt tcg act     1722
 Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser Asp Ser Ser Thr
 485                 490                 495                 500

 gat gac tct gag gag gag cga gcc cag cgg ctg gct gag ctc cag gag     1770
 Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala Glu Leu Gln Glu
                 505                 510                 515

 cag ctc aaa gcc gtg cac gag cag ctt gca gcc ctc tct cag ccc cag     1818
 Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu Ser Gln Pro Gln
             520                 525                 530

 cag aac aaa cca aag aaa aag gag aaa gac aag aag gaa aag aaa aaa     1866
 Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys Glu Lys Lys Lys
         535                 540                 545

 gaa aag cac aaa agg aaa gag gaa gtg gaa gag aat aaa aaa agc aaa     1914
 Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn Lys Lys Ser Lys
     550                 555                 560

 gcc aag gaa cct cct cct aaa aag acg aag aaa aat aat agc agc aac     1962
 Ala Lys Glu Pro Pro Pro Lys Lys Thr Lys Lys Asn Asn Ser Ser Asn
 565                 570                 575                 580

 agc aat gtg agc aag aag gag cca gcg ccc atg aag agc aag ccc cct     2010
 Ser Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys Ser Lys Pro Pro
                 585                 590                 595

 ccc acg tat gag tcg gag gaa gag gac aag tgc aag cct atg tcc tat     2058
 Pro Thr Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys Pro Met Ser Tyr
             600                 605                 610

 gag gag aag cgg cag ctc agc ttg gac atc aac aag ctc ccc ggc gag     2106
 Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys Leu Pro Gly Glu
         615                 620                 625

 aag ctg ggc cgc gtg gtg cac atc atc cag tca cgg gag ccc tcc ctg     2154
 Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu
     630                 635                 640

 aag aat tcc aac ccc gac gag att gaa atc gac ttt gag acc ctg aag     2202
 Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys
 645                 650                 655                 660

 ccg tcc aca ctg cgt gag ctg gag cgc tat gtc acc tcc tgt ttg cgg     2250
 Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Thr Ser Cys Leu Arg
                 665                 670                 675

 aag aaa agg aaa cct caa gct gag aaa gtt gat gtg att gcc ggc tcc     2298
 Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val Ile Ala Gly Ser
             680                 685                 690

 tcc aag atg aag ggc ttc tcg tcc tca gag tcg gag agc tcc agt gag     2346
 Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu Ser Ser Ser Glu
         695                 700                 705

 tcc agc tcc tct gac agc gaa gac tcc gaa aca gag ttg gct ccg aag     2394
 Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Thr Glu Leu Ala Pro Lys
     710                 715                 720

 tca aaa aag aag ggg cac ccc ggg agg gag cag aag aag cac cat cat     2442
 Ser Lys Lys Lys Gly His Pro Gly Arg Glu Gln Lys Lys His His His
 725                 730                 735                 740

 cac cac cat cag cag atg cag cag gcc ccg gct cct gtg ccc cag cag     2490
 His His His Gln Gln Met Gln Gln Ala Pro Ala Pro Val Pro Gln Gln
                 745                 750                 755

 ccg ccc ccg cct ccc cag cag ccc cca ccg cct cca cct ccg cag cag     2538
 Pro Pro Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro Pro Pro Gln Gln
             760                 765                 770

 caa cag cag ccg cca ccc ccg cct ccc cca ccc tcc atg ccg cag cag     2586
 Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Ser Met Pro Gln Gln
         775                 780                 785

 gca gcc ccg gcg atg aag tcc tcg ccc cca ccc ttc att gcc acc cag     2634
 Ala Ala Pro Ala Met Lys Ser Ser Pro Pro Pro Phe Ile Ala Thr Gln
     790                 795                 800

 gtg ccc gtc ctg gag ccc cag ctc cca ggc agc gtc ttt gac ccc atc     2682
 Val Pro Val Leu Glu Pro Gln Leu Pro Gly Ser Val Phe Asp Pro Ile
 805                 810                 815                 820

 ggc cac ttc acc cag ccc atc ctg cac ctg ccg cag cct gag ctg ccc     2730
 Gly His Phe Thr Gln Pro Ile Leu His Leu Pro Gln Pro Glu Leu Pro
                 825                 830                 835

 cct cac ctg ccc cag ccg cct gag cac agc act cca ccc cat ctc aac     2778
 Pro His Leu Pro Gln Pro Pro Glu His Ser Thr Pro Pro His Leu Asn
             840                 845                 850

 cag cac gca gtg gtc tct cct cca gct ttg cac aac gca cta ccc cag     2826
 Gln His Ala Val Val Ser Pro Pro Ala Leu His Asn Ala Leu Pro Gln
         855                 860                 865

 cag cca tca cgg ccc agc aac cga gcc gct gcc ctg cct ccc aag ccc     2874
 Gln Pro Ser Arg Pro Ser Asn Arg Ala Ala Ala Leu Pro Pro Lys Pro
     870                 875                 880

 gcc cgg ccc cca gcc gtg tca cca gcc ttg acc caa aca ccc ctg ctc     2922
 Ala Arg Pro Pro Ala Val Ser Pro Ala Leu Thr Gln Thr Pro Leu Leu
 885                 890                 895                 900

 cca cag ccc ccc atg gcc caa ccc ccc caa gtg ctg ctg gag gat gaa     2970
 Pro Gln Pro Pro Met Ala Gln Pro Pro Gln Val Leu Leu Glu Asp Glu
                 905                 910                 915

 gag cca cct gcc cca ccc ctc acc tcc atg cag atg cag ctg tac ctg     3018
 Glu Pro Pro Ala Pro Pro Leu Thr Ser Met Gln Met Gln Leu Tyr Leu
             920                 925                 930

 cag cag ctg cag aag gtg cag ccc cct acg ccg cta ctc cct tcc gtg     3066
 Gln Gln Leu Gln Lys Val Gln Pro Pro Thr Pro Leu Leu Pro Ser Val
         935                 940                 945

 aag gtg cag tcc cag ccc cca ccc ccc ctg ccg ccc cca ccc cac ccc     3114
 Lys Val Gln Ser Gln Pro Pro Pro Pro Leu Pro Pro Pro Pro His Pro
     950                 955                 960

 tct gtg cag cag cag ctg cag cag cag ccg cca cca ccc cca cca ccc     3162
 Ser Val Gln Gln Gln Leu Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro
 965                 970                 975                 980

 cag ccc cag cct cca ccc cag cag cag cat cag ccc cct cca cgg ccc     3210
 Gln Pro Gln Pro Pro Pro Gln Gln Gln His Gln Pro Pro Pro Arg Pro
                 985                 990                 995

 gtg cac ttg cag ccc atg cag ttt tcc acc cac atc caa cag ccc ccg     3258
 Val His Leu Gln Pro Met Gln Phe Ser Thr His Ile Gln Gln Pro Pro
            1000                1005                1010

 cca ccc cag ggc cag cag ccc ccc cat ccg ccc cca ggc cag cag cca     3306
 Pro Pro Gln Gly Gln Gln Pro Pro His Pro Pro Pro Gly Gln Gln Pro
        1015                1020                1025

 ccc ccg ccg cag cct gcc aag cct cag caa gtc atc cag cac cac cat     3354
 Pro Pro Pro Gln Pro Ala Lys Pro Gln Gln Val Ile Gln His His His
    1030                1035                1040

 tca ccc cgg cac cac aag tcg gac ccc tac tca acc ggt cac ctc cgc     3402
 Ser Pro Arg His His Lys Ser Asp Pro Tyr Ser Thr Gly His Leu Arg
1045                1050                1055                1060

 gaa gcc ccc tcc ccg ctt atg ata cat tcc ccc cag atg tca cag ttc     3450
 Glu Ala Pro Ser Pro Leu Met Ile His Ser Pro Gln Met Ser Gln Phe
                1065                1070                1075

 cag agc ctg acc cac cag tct cca ccc cag caa aac gtc cag cct aag     3498
 Gln Ser Leu Thr His Gln Ser Pro Pro Gln Gln Asn Val Gln Pro Lys
            1080                1085                1090

 aaa cag gag ctg cgt gct gcc tcc gtg gtc cag ccc cag ccc ctc gtg     3546
 Lys Gln Glu Leu Arg Ala Ala Ser Val Val Gln Pro Gln Pro Leu Val
        1095                1100                1105

 gtg gtg aag gag gag aag atc cac tca ccc atc atc cgc agc gag ccc     3594
 Val Val Lys Glu Glu Lys Ile His Ser Pro Ile Ile Arg Ser Glu Pro
    1110                1115                1120

 ttc agc ccc tcg ctg cgg ccg gag ccc ccc aag cac ccg gag agc atc     3642
 Phe Ser Pro Ser Leu Arg Pro Glu Pro Pro Lys His Pro Glu Ser Ile
1125                1130                1135                1140

 aag gcc ccc gtc cac ctg ccc cag cgg ccg gaa atg aag cct gtg gat     3690
 Lys Ala Pro Val His Leu Pro Gln Arg Pro Glu Met Lys Pro Val Asp
                1145                1150                1155

 gtc ggg agg cct gtg atc cgg ccc cca gag cag aac gca ccg cca cca     3738
 Val Gly Arg Pro Val Ile Arg Pro Pro Glu Gln Asn Ala Pro Pro Pro
            1160                1165                1170

 ggg gcc cct gac aag gac aaa tag aaacaggagc cgaagactcc agttgcgccc    3792
 Gly Ala Pro Asp Lys Asp Lys 
        1175

 aaaaaggacc tgaaaatcaa gaacatgggc tcctgggcca gcctagtgca gaagcatccg   3852

 accaccccct cctccacagc caagtcatcc agcgacagct tcgagcagtt ccgccgcgcc   3912

 gctcgggaga aagaggagcg tgagaaggcc ctgaaggctc aggccgagca cgctgagaag   3972

 gagaaggagc ggctgcggca ggagcgcatg aggagccgag aggacgagga tgcgctggag   4032

 caggcccggc gggcccatga ggaggcacgt cggcgccagg agcagcagca gcagcagcgc   4092

 caggagcaac agcagcagca gcaacagcaa gcagctgcgg tggctgccgc cgccacccca   4152

 caggcccaga gctcccagcc ccagtccatg ctggaccagc agagggagtt ggcccggaag   4212

 cgggagcagg agcgaagacg ccgggaagcc atggcagcta ccattgacat gaatttccag   4272

 agtgatctat tgtcaatatt tgaagaaaat cttttctgag cgcaaaaaaa aaa          4325




      <210> 209
      <211> 1597
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (101)..(1537)

      <400> 209
 ctgatagtga cctgttcgtt gcaacaaatt gatgagcaat gcttttttat aatgccaact     60

 ttgtacaaaa aagcaggctt taattaagga ggttaacacc  atg agt cct cca ctg     115
                                              Met Ser Pro Pro Leu
                                                1               5

 ctg aag ctt ggc gct gtg ctt agt acc atg gca atg atc tca aac tgg      163
 Leu Lys Leu Gly Ala Val Leu Ser Thr Met Ala Met Ile Ser Asn Trp
                  10                  15                  20

 atg tcc caa act ctc cca tcc ttg gtg gga ctg aac acc acg agg ctg      211
 Met Ser Gln Thr Leu Pro Ser Leu Val Gly Leu Asn Thr Thr Arg Leu
              25                  30                  35

 tcg act ccg gat acc tta act cag att agt cct aaa gaa ggg tgg cag      259
 Ser Thr Pro Asp Thr Leu Thr Gln Ile Ser Pro Lys Glu Gly Trp Gln
          40                  45                  50

 gtg tac agc tca gct cag gat cct gat ggg cgg tgc att tgc aca gtt      307
 Val Tyr Ser Ser Ala Gln Asp Pro Asp Gly Arg Cys Ile Cys Thr Val
      55                  60                  65

 gtt gct cca gaa caa aac ctg tgt tcc cgg gat gcc aaa agc agg caa      355
 Val Ala Pro Glu Gln Asn Leu Cys Ser Arg Asp Ala Lys Ser Arg Gln
  70                  75                  80                  85

 ctt cgc caa cta ctg gaa aag gtt cag aac atg tcc cag tct att gaa      403
 Leu Arg Gln Leu Leu Glu Lys Val Gln Asn Met Ser Gln Ser Ile Glu
                  90                  95                 100

 gtc tta aac ttg aga act cag aga gat ttc caa tat gtt tta aaa atg      451
 Val Leu Asn Leu Arg Thr Gln Arg Asp Phe Gln Tyr Val Leu Lys Met
             105                 110                 115

 gaa acc caa atg aaa ggg ctg aag gca aaa ttt cgg cag att gaa gat      499
 Glu Thr Gln Met Lys Gly Leu Lys Ala Lys Phe Arg Gln Ile Glu Asp
         120                 125                 130

 gat cga aag aca ctt atg acc aag cat ttt cag gag ttg aaa gag aaa      547
 Asp Arg Lys Thr Leu Met Thr Lys His Phe Gln Glu Leu Lys Glu Lys
     135                 140                 145

 ctg gac gag ctc ctg cct ttg atc ccc gtg ctg gaa cag tac aaa aca      595
 Leu Asp Glu Leu Leu Pro Leu Ile Pro Val Leu Glu Gln Tyr Lys Thr
 150                 155                 160                 165

 gat gct aag tta atc acc cag ttc aag gag gaa ata agg aat ctg tct      643
 Asp Ala Lys Leu Ile Thr Gln Phe Lys Glu Glu Ile Arg Asn Leu Ser
                 170                 175                 180

 gct gtc ctc act ggt att cag gag gaa att ggt gcc tat gac tac gag      691
 Ala Val Leu Thr Gly Ile Gln Glu Glu Ile Gly Ala Tyr Asp Tyr Glu
             185                 190                 195

 gaa cta cac caa aga gtg ctg aac ttg gaa aca aga ctt cgt gac tgc      739
 Glu Leu His Gln Arg Val Leu Asn Leu Glu Thr Arg Leu Arg Asp Cys
         200                 205                 210

 atg aaa aag cta aca tgt ggc aaa ctg atg aaa atc aca ggc cca gtt      787
 Met Lys Lys Leu Thr Cys Gly Lys Leu Met Lys Ile Thr Gly Pro Val
     215                 220                 225

 aca gtc aag aca tct gga acc cga ttt ggt gct tgg atg aca gac cct      835
 Thr Val Lys Thr Ser Gly Thr Arg Phe Gly Ala Trp Met Thr Asp Pro
 230                 235                 240                 245

 tta gca tct gag aaa aac aac aga gtc tgg tac atg gac agt tat act      883
 Leu Ala Ser Glu Lys Asn Asn Arg Val Trp Tyr Met Asp Ser Tyr Thr
                 250                 255                 260

 aac aat aaa att gtt cgt gaa tac aaa tca att gca gac ttt gtc agt      931
 Asn Asn Lys Ile Val Arg Glu Tyr Lys Ser Ile Ala Asp Phe Val Ser
             265                 270                 275

 ggg gct gaa tca agg aca tac aac ctt cct ttc aag tgg gca gga act      979
 Gly Ala Glu Ser Arg Thr Tyr Asn Leu Pro Phe Lys Trp Ala Gly Thr
         280                 285                 290

 aac cat gtt gtc tac aat ggc tca ctc tat ttt aac aag tat cag agt     1027
 Asn His Val Val Tyr Asn Gly Ser Leu Tyr Phe Asn Lys Tyr Gln Ser
     295                 300                 305

 aat atc atc atc aaa tac agc ttt gat atg ggg aga gtg ctt gcc caa     1075
 Asn Ile Ile Ile Lys Tyr Ser Phe Asp Met Gly Arg Val Leu Ala Gln
 310                 315                 320                 325

 cga agc ctg gag tat gct ggt ttt cat aat gtt tac ccc tac aca tgg     1123
 Arg Ser Leu Glu Tyr Ala Gly Phe His Asn Val Tyr Pro Tyr Thr Trp
                 330                 335                 340

 ggt gga ttc tct gac atc gac cta atg gct gat gaa atc ggg ctg tgg     1171
 Gly Gly Phe Ser Asp Ile Asp Leu Met Ala Asp Glu Ile Gly Leu Trp
             345                 350                 355

 gct gtg tat gca act aac cag aat gca ggc aat att gtc atc agc caa     1219
 Ala Val Tyr Ala Thr Asn Gln Asn Ala Gly Asn Ile Val Ile Ser Gln
         360                 365                 370

 ctt aac caa gat acc ttg gag gtg atg aag agc tgg agc act ggc tac     1267
 Leu Asn Gln Asp Thr Leu Glu Val Met Lys Ser Trp Ser Thr Gly Tyr
     375                 380                 385

 ccc aag aga agt gca ggg gaa tct ttc atg atc tgt ggg aca ctg tat     1315
 Pro Lys Arg Ser Ala Gly Glu Ser Phe Met Ile Cys Gly Thr Leu Tyr
 390                 395                 400                 405

 gtc acc aac tcc cac tta act gga gcc aag gtg tat tat tcc tat tcc     1363
 Val Thr Asn Ser His Leu Thr Gly Ala Lys Val Tyr Tyr Ser Tyr Ser
                 410                 415                 420

 acc aaa acc tcc aca tat gag tac aca gac att ccc ttc cat aac caa     1411
 Thr Lys Thr Ser Thr Tyr Glu Tyr Thr Asp Ile Pro Phe His Asn Gln
             425                 430                 435

 tac ttt cac ata tcc atg ctt gac tac aat gca aga gat cga gct ctc     1459
 Tyr Phe His Ile Ser Met Leu Asp Tyr Asn Ala Arg Asp Arg Ala Leu
         440                 445                 450

 tat gcc tgg aac aat ggc cac cag gtg ctg ttc aat gtc acc ctt ttc     1507
 Tyr Ala Trp Asn Asn Gly His Gln Val Leu Phe Asn Val Thr Leu Phe
     455                 460                 465

 cat atc atc aag aca gag gat gac aca tag t atataaaccg aggtacctgc     1558
 His Ile Ile Lys Thr Glu Asp Asp Thr 
 470                 475

 tagcacacat acccagcttt cttgtacaaa gtggtcccc                          1597




      <210> 210
      <211> 4755
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (367)..(2907)

      <400> 210
 gtactgtcca ctgtgctgtc ggtgctgaac ctgagacgcg agcggaccag ttgctccagc     60

 acctgaaggc aacgccctct tgcaccctct gtgccctgtg ggacccgctt caccaacagg    120

 acccatatca acttgacaaa ggagtgtggt atcggacgtg ggagagagtc ctctgtttgc    180

 cacctgggcg ctcattcagg cgtgactttg gagatttcta tagttttaga ccaaactatt    240

 ttttttcccc agctaagacg atcttttgag agtttttttt tttattgtga tttatatttc    300

 cacagcgttt aggaatcttt ctgggggact tttgtgactg ttaaaataag gtgaaaagca    360

 ataagg   atg ttt aag tgc tgg tca gtt gtc ttg gtt ctc gga ttc att     408
          Met Phe Lys Cys Trp Ser Val Val Leu Val Leu Gly Phe Ile
            1               5                  10

 ttt ctg gag tcg gaa gga agg cca acc aaa gaa gga gga tat ggc ctt      456
 Phe Leu Glu Ser Glu Gly Arg Pro Thr Lys Glu Gly Gly Tyr Gly Leu
  15                  20                  25                  30

 aaa tcc tat cag cct cta atg aga ttg cga cat aag gaa aaa aat caa      504
 Lys Ser Tyr Gln Pro Leu Met Arg Leu Arg His Lys Glu Lys Asn Gln
                  35                  40                  45

 gaa agt tca aga gtc aaa gga ttt atg att cag gat ggc cct ttt gga      552
 Glu Ser Ser Arg Val Lys Gly Phe Met Ile Gln Asp Gly Pro Phe Gly
              50                  55                  60

 tct tgt gaa aat aag tac tgt ggt ttg gga aga cac tgt gtt acc agc      600
 Ser Cys Glu Asn Lys Tyr Cys Gly Leu Gly Arg His Cys Val Thr Ser
          65                  70                  75

 aga gag aca ggg caa gca gaa tgt gcc tgt atg gac ctt tgc aaa cgt      648
 Arg Glu Thr Gly Gln Ala Glu Cys Ala Cys Met Asp Leu Cys Lys Arg
      80                  85                  90

 cac tac aaa cct gtg tgt gga tct gac gga gaa ttc tat gaa aac cac      696
 His Tyr Lys Pro Val Cys Gly Ser Asp Gly Glu Phe Tyr Glu Asn His
  95                 100                 105                 110

 tgt gaa gtg cac aga gct gct tgc ctg aaa aaa caa aag att acc att      744
 Cys Glu Val His Arg Ala Ala Cys Leu Lys Lys Gln Lys Ile Thr Ile
                 115                 120                 125

 gtt cac aat gaa gac tgc ttc ttt aaa gga gat aag tgc aag act act      792
 Val His Asn Glu Asp Cys Phe Phe Lys Gly Asp Lys Cys Lys Thr Thr
             130                 135                 140

 gaa tac agc aag atg aaa aat atg cta tta gat tta caa aat caa aaa      840
 Glu Tyr Ser Lys Met Lys Asn Met Leu Leu Asp Leu Gln Asn Gln Lys
         145                 150                 155

 tat att atg caa gaa aat gaa aat cct aat ggc gac gac ata tct cgg      888
 Tyr Ile Met Gln Glu Asn Glu Asn Pro Asn Gly Asp Asp Ile Ser Arg
     160                 165                 170

 aag aag cta ttg gtg gat caa atg ttt aaa tat ttt gat gca gac agt      936
 Lys Lys Leu Leu Val Asp Gln Met Phe Lys Tyr Phe Asp Ala Asp Ser
 175                 180                 185                 190

 aat gga ctt gta gat att aat gaa cta act cag gtg ata aaa cag gaa      984
 Asn Gly Leu Val Asp Ile Asn Glu Leu Thr Gln Val Ile Lys Gln Glu
                 195                 200                 205

 gaa ctt ggc aag gat ctc ttt gat tgt act ttg tat gtt cta ttg aaa     1032
 Glu Leu Gly Lys Asp Leu Phe Asp Cys Thr Leu Tyr Val Leu Leu Lys
             210                 215                 220

 tat gat gat ttt aat gct gac aag cac ctg gct ctt gaa gaa ttt tat     1080
 Tyr Asp Asp Phe Asn Ala Asp Lys His Leu Ala Leu Glu Glu Phe Tyr
         225                 230                 235

 aga gca ttc caa gtg atc cag ttg agt ctg cca gaa gat caa aaa cta     1128
 Arg Ala Phe Gln Val Ile Gln Leu Ser Leu Pro Glu Asp Gln Lys Leu
     240                 245                 250

 agc atc act gca gca act gtg gga caa agt gct gtt ctg agc tgt gcc     1176
 Ser Ile Thr Ala Ala Thr Val Gly Gln Ser Ala Val Leu Ser Cys Ala
 255                 260                 265                 270

 att caa gga acc ctg aga cct ccc att atc tgg aaa agg aac aat att     1224
 Ile Gln Gly Thr Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn Asn Ile
                 275                 280                 285

 att cta aat aat tta gat ttg gaa gac atc aat gac ttt gga gat gat     1272
 Ile Leu Asn Asn Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly Asp Asp
             290                 295                 300

 ggg tcc ttg tat att act aag gtt acc aca act cac gtt ggc aat tac     1320
 Gly Ser Leu Tyr Ile Thr Lys Val Thr Thr Thr His Val Gly Asn Tyr
         305                 310                 315

 acc tgc tat gca gat ggc tat gaa caa gtc tat cag act cac atc ttc     1368
 Thr Cys Tyr Ala Asp Gly Tyr Glu Gln Val Tyr Gln Thr His Ile Phe
     320                 325                 330

 caa gtg aat gtt cct cca gtc atc cgg gtg tat cca gag agt cag gct     1416
 Gln Val Asn Val Pro Pro Val Ile Arg Val Tyr Pro Glu Ser Gln Ala
 335                 340                 345                 350

 aga gag cct ggg gta act gcc agt ctt agg tgc cat gca gag ggc ata     1464
 Arg Glu Pro Gly Val Thr Ala Ser Leu Arg Cys His Ala Glu Gly Ile
                 355                 360                 365

 cca aag cct cag ctt ggc tgg ttg aag aat gga att gat att aca cca     1512
 Pro Lys Pro Gln Leu Gly Trp Leu Lys Asn Gly Ile Asp Ile Thr Pro
             370                 375                 380

 aag ctt tcc aaa caa ctc acg ctt caa gca aat ggc agt gag gtt cac     1560
 Lys Leu Ser Lys Gln Leu Thr Leu Gln Ala Asn Gly Ser Glu Val His
         385                 390                 395

 ata agc aat gtg cgc tat gaa gat act gga gca tac act tgt atc gca     1608
 Ile Ser Asn Val Arg Tyr Glu Asp Thr Gly Ala Tyr Thr Cys Ile Ala
     400                 405                 410

 aag aat gaa gca gga gtg gat gaa gac atc tct tct ctt ttt gtg gaa     1656
 Lys Asn Glu Ala Gly Val Asp Glu Asp Ile Ser Ser Leu Phe Val Glu
 415                 420                 425                 430

 gac tct gct aga aag acc cta gct aac ata tta tgg aga gaa gaa ggt     1704
 Asp Ser Ala Arg Lys Thr Leu Ala Asn Ile Leu Trp Arg Glu Glu Gly
                 435                 440                 445

 ctg gga att ggg aac atg ttc tat gtt ttt tat gaa gat gga atc aaa     1752
 Leu Gly Ile Gly Asn Met Phe Tyr Val Phe Tyr Glu Asp Gly Ile Lys
             450                 455                 460

 gtg ata caa ccc ata gaa tgt gaa ttt cag agg cac att aag cct agt     1800
 Val Ile Gln Pro Ile Glu Cys Glu Phe Gln Arg His Ile Lys Pro Ser
         465                 470                 475

 gaa aag ctc ctt gga ttt cag gat gaa gtc tgt ccc aaa gct gag gga     1848
 Glu Lys Leu Leu Gly Phe Gln Asp Glu Val Cys Pro Lys Ala Glu Gly
     480                 485                 490

 gat gaa gtt cag agg tgt gtg tgg gca tca gct gtt aat gtc aaa gac     1896
 Asp Glu Val Gln Arg Cys Val Trp Ala Ser Ala Val Asn Val Lys Asp
 495                 500                 505                 510

 aag ttc att tat gtt gca cag cca act ttg gac aga gtc ctt att gtt     1944
 Lys Phe Ile Tyr Val Ala Gln Pro Thr Leu Asp Arg Val Leu Ile Val
                 515                 520                 525

 gat gtg cag tcc caa aaa gtt gtt cag gca gtg agc aca gac cct gtc     1992
 Asp Val Gln Ser Gln Lys Val Val Gln Ala Val Ser Thr Asp Pro Val
             530                 535                 540

 cca gtt aaa tta cac tat gac aaa tca cat gat cag gtc tgg gtg cta     2040
 Pro Val Lys Leu His Tyr Asp Lys Ser His Asp Gln Val Trp Val Leu
         545                 550                 555

 agc tgg ggt acc ttg gag aag aca tca cca aca cta cag gta att acc     2088
 Ser Trp Gly Thr Leu Glu Lys Thr Ser Pro Thr Leu Gln Val Ile Thr
     560                 565                 570

 ctg gcc agt ggg aat gtg cct cac cac acg atc cac acc caa cca gtg     2136
 Leu Ala Ser Gly Asn Val Pro His His Thr Ile His Thr Gln Pro Val
 575                 580                 585                 590

 gga aag caa ttt gac aga gtg gat gat ttt ttc att ccc acc aca aca     2184
 Gly Lys Gln Phe Asp Arg Val Asp Asp Phe Phe Ile Pro Thr Thr Thr
                 595                 600                 605

 ctc att atc acc cat atg agg ttt gga ttt att ctt cat aaa gat gaa     2232
 Leu Ile Ile Thr His Met Arg Phe Gly Phe Ile Leu His Lys Asp Glu
             610                 615                 620

 gct gca cta caa aaa att gat ctt gaa acc atg tca tac atc aag aca     2280
 Ala Ala Leu Gln Lys Ile Asp Leu Glu Thr Met Ser Tyr Ile Lys Thr
         625                 630                 635

 att aac ttg aag gac tat aag tgc gtt cct cag tca ttg gca tat aca     2328
 Ile Asn Leu Lys Asp Tyr Lys Cys Val Pro Gln Ser Leu Ala Tyr Thr
     640                 645                 650

 cac ttg gga ggc tac tac ttc att ggc tgc aaa cct gac agc acc gga     2376
 His Leu Gly Gly Tyr Tyr Phe Ile Gly Cys Lys Pro Asp Ser Thr Gly
 655                 660                 665                 670

 gca gtt tcc cca cag gtc atg gtg gac ggt gta act gac tca gtc att     2424
 Ala Val Ser Pro Gln Val Met Val Asp Gly Val Thr Asp Ser Val Ile
                 675                 680                 685

 ggg ttc aat agt gat gtg acg ggc act cca tat gtc tct cca gat ggc     2472
 Gly Phe Asn Ser Asp Val Thr Gly Thr Pro Tyr Val Ser Pro Asp Gly
             690                 695                 700

 cac tac ctt gtc agc att aat gat gtg aaa ggt ctt gta agg gtt cag     2520
 His Tyr Leu Val Ser Ile Asn Asp Val Lys Gly Leu Val Arg Val Gln
         705                 710                 715

 tac att acc atc aga gga gaa ata cag gag gct ttt gat att tac aca     2568
 Tyr Ile Thr Ile Arg Gly Glu Ile Gln Glu Ala Phe Asp Ile Tyr Thr
     720                 725                 730

 aat ctg cac ata tct gat ctg gca ttt caa cca tcc ttt act gaa gcc     2616
 Asn Leu His Ile Ser Asp Leu Ala Phe Gln Pro Ser Phe Thr Glu Ala
 735                 740                 745                 750

 cac caa tat aac atc tac ggt agt tca agc aca caa act gat gtg ctc     2664
 His Gln Tyr Asn Ile Tyr Gly Ser Ser Ser Thr Gln Thr Asp Val Leu
                 755                 760                 765

 ttt gtg gag ctc tct tct ggg aag gtc aag atg ata aag agt ctc aag     2712
 Phe Val Glu Leu Ser Ser Gly Lys Val Lys Met Ile Lys Ser Leu Lys
             770                 775                 780

 gaa cca ctc aag gca gaa gaa tgg cct tgg aac cgg aaa aac agg caa     2760
 Glu Pro Leu Lys Ala Glu Glu Trp Pro Trp Asn Arg Lys Asn Arg Gln
         785                 790                 795

 atc cag gac agt ggc ttg ttt ggt caa tac ctg atg aca cct tcc aag     2808
 Ile Gln Asp Ser Gly Leu Phe Gly Gln Tyr Leu Met Thr Pro Ser Lys
     800                 805                 810

 gac tct ctc ttc atc cta gat gga cga ctc aat aaa tta aac tgt gag     2856
 Asp Ser Leu Phe Ile Leu Asp Gly Arg Leu Asn Lys Leu Asn Cys Glu
 815                 820                 825                 830

 atc act gaa gtt gaa aaa gga aat aca gtc att tgg gtt gga gat gcc     2904
 Ile Thr Glu Val Glu Lys Gly Asn Thr Val Ile Trp Val Gly Asp Ala
                 835                 840                 845

 taa aaac cctacgatac aattattgaa tgaagcgttt tacaatacat tgcacttaat     2961
 


 ccattgttta aatttacaac ttaactttcc aagtttatat cctagtcaaa caaaatttac   3021

 ttggttggtc caaataaaat aaattgtttt tgactaagtg actaagacat acacaattaa   3081

 ttatattggt taattagaaa tactcagcac aatatttaat gagaaatcac atcagtcaca   3141

 agaatcaaat atgtaaatta tgctttaaac aataaagtag gatttaaatc atttaaaaaa   3201

 ctaaactgca gggaatttca gatgacataa agcattattt cattttgagg gtagtttatt   3261

 ttttttctct gtccttttgg tatgattaaa caagaaataa aaggtgttgt ggaaacttaa   3321

 aattcttaat tcaaaatatt cggtcctgtc cactgtttat aatattttgt gccttgaagg   3381

 gaatgtcaca ggaggaaaag gaagactaaa gcctgcatac taaatgctct cataactata   3441

 aatctcttgt tgttaaaaaa catctcttgc accaaatcct gtcttcagtc ttttgtttaa   3501

 ccctcaatga actaccaatt gaaggcataa gttggtctta ggttgtatac aggtgtcaaa   3561

 ctccacttga catttactgt ataatctgca gcatgctata gaaagtgggg aggaagggag   3621

 gaaaaataat tacagtcaaa atatttgcaa tctatctact cattttgctt tcaatcacta   3681

 gagtgcatta tgtttttaat gcaagtttgt ctgggatgtc aactgcctac agatgtttat   3741

 tactagcaga atagattatt tattaataga ttgtttcttt tcatatagtc caatgtttca   3801

 tcatcaggaa ctttcggttt taaaaaagaa acattacttt tgtctgctaa agtaaaccat   3861

 atatagggaa attaacacct aggaaaagaa aactggcaag agaattgatg aggtattagt   3921

 ggcttagaag aattagtaat ataagttggg aataaagggg tagcccgaca gtggtaagta   3981

 aaaatgtagt actccattgt ttttgctatt taaatataat gtatcaaaaa cctttattct   4041

 aaaatttcca caaatgattc cttttatcca tcttcttgta atcctaaaag catcttctca   4101

 ctatgtgctg tagtttgaaa cctaacgaat cctcctactt gagacactgt agaaaagtaa   4161

 aaattgttgc ttctgttttg ttttaagagg aaatgagaag gccagcagaa gtagattaaa   4221

 actagagagc tggtttatta aaataagcag ataattatcc aggcttaaag taatagctta   4281

 catgttttga aaatccttgt acttattttt gtttttattg ttgcaaaaaa atgttaatgg   4341

 gctgttgaaa tgacctccat ttacttaagg taatccaata aggtcttttt taaatataca   4401

 aattttactc aagtttaaat tgtataaaac tgcttagaaa cctgaaattt tatagtgtgt   4461

 aatatcttat gtgtatatag catcctgagc tgtgtgatac agtagatttc ttcttagcag   4521

 aaacatgcga ggtagattta ataaacaaca aaaatcagct tatgtttcta cttattgaat   4581

 ctgctttact ttttagcaat tttcttcctt gtgaacatga accatataaa gtgtctgtga   4641

 cttaatgatt tcatgtaagt ctgtcgcata catccttctt ttgtagctta caccatgtgg   4701

 atgctctgtc tgtagacact gcttgataaa aggagaataa acctcttaca tttt         4755




      <210> 211
      <211> 1662
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (210)..(1472)

      <220>
      <221> misc_feature
      <222> (1)...(1662)
      <223> n = a,t,c or g

      <400> 211
 cctgccctcc caaagaaaca cccctcatcc agtctcttcc agcctagaga tcctggccta     60

 cccctccgcc aaagcgcgca ctgagtgcaa accccagagt caatccctgt cccggctccg    120

 ccccccgcgt ccgaatcccg cccagccggg ccctcaagcc cagtcgggac tcgagcctag    180

 ggaggcgagg ttcccgcacc ggatagaaa  atg tca ctg aaa ttc aca aat gca     233
                                  Met Ser Leu Lys Phe Thr Asn Ala
                                    1               5

 aaa cgg att gaa gga ctt gat agt aat gtg tgg att gaa ttt acc aaa      281
 Lys Arg Ile Glu Gly Leu Asp Ser Asn Val Trp Ile Glu Phe Thr Lys
      10                  15                  20

 ttg gct gca gac cct tct gtt gtg aat ctt ggc caa ggc ttt cca gat      329
 Leu Ala Ala Asp Pro Ser Val Val Asn Leu Gly Gln Gly Phe Pro Asp
  25                  30                  35                  40

 ata tcc cct cct aca tat gta aaa gaa gaa tta tca aag att gca gca      377
 Ile Ser Pro Pro Thr Tyr Val Lys Glu Glu Leu Ser Lys Ile Ala Ala
                  45                  50                  55

 atc gat agc ctg aat cag tat aca cga ggc ttt ggc cat cca tca ctt      425
 Ile Asp Ser Leu Asn Gln Tyr Thr Arg Gly Phe Gly His Pro Ser Leu
              60                  65                  70

 gtg aaa gct ctg tcc tat ctg tat gaa aag ctt tat caa aag caa att      473
 Val Lys Ala Leu Ser Tyr Leu Tyr Glu Lys Leu Tyr Gln Lys Gln Ile
          75                  80                  85

 gat tca aat aaa gaa atc ctt gtg aca gta gga gca tat gga tct ctt      521
 Asp Ser Asn Lys Glu Ile Leu Val Thr Val Gly Ala Tyr Gly Ser Leu
      90                  95                 100

 ttt aac acc att caa gca tta att gat gag gga gat gaa gtc ata cta      569
 Phe Asn Thr Ile Gln Ala Leu Ile Asp Glu Gly Asp Glu Val Ile Leu
 105                 110                 115                 120

 ata gtg cct ttc tat gac tgc tat gag ccc atg gtg aga atg gct gga      617
 Ile Val Pro Phe Tyr Asp Cys Tyr Glu Pro Met Val Arg Met Ala Gly
                 125                 130                 135

 gca aca cct gtt ttt att ccc ctg aga tct aaa cct gtt tat gga aaa      665
 Ala Thr Pro Val Phe Ile Pro Leu Arg Ser Lys Pro Val Tyr Gly Lys
             140                 145                 150

 aga tgg tct agt tct gac tgg aca tta gat cct caa gaa ctg gaa agt      713
 Arg Trp Ser Ser Ser Asp Trp Thr Leu Asp Pro Gln Glu Leu Glu Ser
         155                 160                 165

 aaa ttt aat tcc aaa acc aaa gct att ata cta aat act cca cat aac      761
 Lys Phe Asn Ser Lys Thr Lys Ala Ile Ile Leu Asn Thr Pro His Asn
     170                 175                 180

 cca ctt ggc aag gtg tat aac aga gag gaa ctg caa gta att gct gac      809
 Pro Leu Gly Lys Val Tyr Asn Arg Glu Glu Leu Gln Val Ile Ala Asp
 185                 190                 195                 200

 ctt tgc atc aaa tat gac aca ctc tgc atc agc gat gag gtt tat gaa      857
 Leu Cys Ile Lys Tyr Asp Thr Leu Cys Ile Ser Asp Glu Val Tyr Glu
                 205                 210                 215

 tgg ctt gta tat tct gga aat aag cac tta aaa ata gct act ttt cca      905
 Trp Leu Val Tyr Ser Gly Asn Lys His Leu Lys Ile Ala Thr Phe Pro
             220                 225                 230

 ggt atg tgg gag aga aca ata aca ata gga agt gct gga aag act ttc      953
 Gly Met Trp Glu Arg Thr Ile Thr Ile Gly Ser Ala Gly Lys Thr Phe
         235                 240                 245

 agt gta act ggc tgg aag ctt ggc tgg tcc att ggt cca aat cat ttg     1001
 Ser Val Thr Gly Trp Lys Leu Gly Trp Ser Ile Gly Pro Asn His Leu
     250                 255                 260

 ata aaa cat tta cag aca gtt caa caa aac acg att tat act tgt gca     1049
 Ile Lys His Leu Gln Thr Val Gln Gln Asn Thr Ile Tyr Thr Cys Ala
 265                 270                 275                 280

 act cct tta cag gaa gcc ttg gct caa gct ttc tgg att gac atc aag     1097
 Thr Pro Leu Gln Glu Ala Leu Ala Gln Ala Phe Trp Ile Asp Ile Lys
                 285                 290                 295

 cgc atg gat gac cca caa tgt tac ttt aat tct ttg ccg aaa gag tta     1145
 Arg Met Asp Asp Pro Gln Cys Tyr Phe Asn Ser Leu Pro Lys Glu Leu
             300                 305                 310

 gaa gta aaa aga gat cgg atg gta cgt tta ctt gaa agt gtt ggc cta     1193
 Glu Val Lys Arg Asp Arg Met Val Arg Leu Leu Glu Ser Val Gly Leu
         315                 320                 325

 aaa ccc ata gtt cct gat gga gga tac atc atc atc gct gat gtg tct     1241
 Lys Pro Ile Val Pro Asp Gly Gly Tyr Ile Ile Ile Ala Asp Val Ser
     330                 335                 340

 ttg cta gat cca gac ctc tct gat atg aag aat aat gag cct tat gac     1289
 Leu Leu Asp Pro Asp Leu Ser Asp Met Lys Asn Asn Glu Pro Tyr Asp
 345                 350                 355                 360

 tat aag ttt gtg aaa tgg atg act aaa cat aag aaa cta tca gcc atc     1337
 Tyr Lys Phe Val Lys Trp Met Thr Lys His Lys Lys Leu Ser Ala Ile
                 365                 370                 375

 ccc gtt tca gca ttc tgt aac tca gag act aaa tca cag ttt gag aag     1385
 Pro Val Ser Ala Phe Cys Asn Ser Glu Thr Lys Ser Gln Phe Glu Lys
             380                 385                 390

 ttt gtg cgt ttt tgc ttc att aaa aaa gac agc aca ctg gat gct gct     1433
 Phe Val Arg Phe Cys Phe Ile Lys Lys Asp Ser Thr Leu Asp Ala Ala
         395                 400                 405

 gaa gaa atc atc aag gca tgg agt gta cag aag tct tga tttgtgcaga      1482
 Glu Glu Ile Ile Lys Ala Trp Ser Val Gln Lys Ser 
     410                 415                 420

 atggattaat gtttctgtta gatgacctag tatgggaatt gttacttagt gctgccacct   1542

 gctgggatgt taaaagaatg taggaagcga ggcctgggan gtgaaggcag ccctcttccc   1602

 tttcatgcca cagctagcca tgaggggtga atgtcttata ttaataaggn tgggcagtgc   1662




      <210> 212
      <211> 3499
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (99)..(1820)

      <400> 212
 cggcgggcgg gcggaggata gcgcgggcgc ggcacctgcg ggcccgaggg tctggctgtc     60

 gcagcgccgg gccgccccga ctccgagcgg ctgctgag    atg agt gca gtg tcg     113
                                              Met Ser Ala Val Ser
                                                1               5

 cag ccc cag gct gct ccc agc ccg ctg gag aag tcg ccc agc acg gcg      161
 Gln Pro Gln Ala Ala Pro Ser Pro Leu Glu Lys Ser Pro Ser Thr Ala
                  10                  15                  20

 atc ctg tgc aac acg tgt ggg aat gtg tgc aag ggc gag gtg ctg cgg      209
 Ile Leu Cys Asn Thr Cys Gly Asn Val Cys Lys Gly Glu Val Leu Arg
              25                  30                  35

 gtg cag gac aag tac ttc cac atc aag tgc ttc gtc tgt aaa gca tgt      257
 Val Gln Asp Lys Tyr Phe His Ile Lys Cys Phe Val Cys Lys Ala Cys
          40                  45                  50

 ggc tgc gac ctg gcc gag ggc ggc ttc ttc gtg cgg cag ggc gag tac      305
 Gly Cys Asp Leu Ala Glu Gly Gly Phe Phe Val Arg Gln Gly Glu Tyr
      55                  60                  65

 atc tgc acg ctg gac tac cag agg ctc tac ggc acc cgc tgc ttc agc      353
 Ile Cys Thr Leu Asp Tyr Gln Arg Leu Tyr Gly Thr Arg Cys Phe Ser
  70                  75                  80                  85

 tgc gac cag ttc att gag ggt gag gtg gtg tcg gcg ctg ggc aag acc      401
 Cys Asp Gln Phe Ile Glu Gly Glu Val Val Ser Ala Leu Gly Lys Thr
                  90                  95                 100

 tac cac ccc gac tgc ttc gtg tgt gcc gtc tgc cgg ctg ccc ttc ccc      449
 Tyr His Pro Asp Cys Phe Val Cys Ala Val Cys Arg Leu Pro Phe Pro
             105                 110                 115

 ccc ggg gac cga gtg acc ttc aac ggg aag gaa tgc atg tgc cag aag      497
 Pro Gly Asp Arg Val Thr Phe Asn Gly Lys Glu Cys Met Cys Gln Lys
         120                 125                 130

 tgt tcc ctg ccc gta tcg gtg ggc agc agc gcg cac ctg tcc cag ggc      545
 Cys Ser Leu Pro Val Ser Val Gly Ser Ser Ala His Leu Ser Gln Gly
     135                 140                 145

 ctc cga agt tgt ggg ggc tgc ggc aca gaa atc aag aat ggc cag gcc      593
 Leu Arg Ser Cys Gly Gly Cys Gly Thr Glu Ile Lys Asn Gly Gln Ala
 150                 155                 160                 165

 ctg gta gcc ttg gac aag cac tgg cac ttg ggc tgt ttt aag tgc aag      641
 Leu Val Ala Leu Asp Lys His Trp His Leu Gly Cys Phe Lys Cys Lys
                 170                 175                 180

 agc tgt ggg aag ctc ctg aat gcc gag tac atc agc aag gat ggg ctg      689
 Ser Cys Gly Lys Leu Leu Asn Ala Glu Tyr Ile Ser Lys Asp Gly Leu
             185                 190                 195

 ccc tac tgc gaa gct gac tat cac gcc aag ttc ggc atc cgc tgt gac      737
 Pro Tyr Cys Glu Ala Asp Tyr His Ala Lys Phe Gly Ile Arg Cys Asp
         200                 205                 210

 agc tgt gag aaa tac atc acg ggg cgc gtg ctg gag gcc gga gag aag      785
 Ser Cys Glu Lys Tyr Ile Thr Gly Arg Val Leu Glu Ala Gly Glu Lys
     215                 220                 225

 cac tac cac cct tcc tgc gcg cta tgt gtc agg tgc ggc cag atg ttt      833
 His Tyr His Pro Ser Cys Ala Leu Cys Val Arg Cys Gly Gln Met Phe
 230                 235                 240                 245

 gca gaa ggc gaa gag atg tat ctt caa ggt tcc tcc atc tgg cat ccg      881
 Ala Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Ser Ile Trp His Pro
                 250                 255                 260

 gcg tgt cga caa gca gcc aga act gaa gac aga aac aag gaa acc aga      929
 Ala Cys Arg Gln Ala Ala Arg Thr Glu Asp Arg Asn Lys Glu Thr Arg
             265                 270                 275

 act tcc tca gag agc atc att tct gtc cct gct tcc agc acc tca ggg      977
 Thr Ser Ser Glu Ser Ile Ile Ser Val Pro Ala Ser Ser Thr Ser Gly
         280                 285                 290

 tct ccg agc cgt gtg att tat gcc aag ctt ggt ggt gag atc ctg gac     1025
 Ser Pro Ser Arg Val Ile Tyr Ala Lys Leu Gly Gly Glu Ile Leu Asp
     295                 300                 305

 tac agg gac ttg gca gcc ctt cct aaa agt aag gcc atc tat gac atc     1073
 Tyr Arg Asp Leu Ala Ala Leu Pro Lys Ser Lys Ala Ile Tyr Asp Ile
 310                 315                 320                 325

 gac cgc ccc gac atg atc tcc tac tca ccc tac atc agc cac tct gca     1121
 Asp Arg Pro Asp Met Ile Ser Tyr Ser Pro Tyr Ile Ser His Ser Ala
                 330                 335                 340

 ggg gac agg cag agc tac ggc gag ggg gat cag gat gac cgg tcc tac     1169
 Gly Asp Arg Gln Ser Tyr Gly Glu Gly Asp Gln Asp Asp Arg Ser Tyr
             345                 350                 355

 aag cag tgc cgg acc tcc agc cca agc tcc act ggg tcg gtt agc ctc     1217
 Lys Gln Cys Arg Thr Ser Ser Pro Ser Ser Thr Gly Ser Val Ser Leu
         360                 365                 370

 ggg cgc tac act ccg acc tca cgg tca cca cag cac tac agc cgt cca     1265
 Gly Arg Tyr Thr Pro Thr Ser Arg Ser Pro Gln His Tyr Ser Arg Pro
     375                 380                 385

 ggc agt gaa agt ggc cgg agc acc ccc agc ctc tcc gtg ctc tct gac     1313
 Gly Ser Glu Ser Gly Arg Ser Thr Pro Ser Leu Ser Val Leu Ser Asp
 390                 395                 400                 405

 agc aag ccg ccc ccc tcc acc tac cag cag gca cct cgc cac ttc cac     1361
 Ser Lys Pro Pro Pro Ser Thr Tyr Gln Gln Ala Pro Arg His Phe His
                 410                 415                 420

 gtc cca gac act ggc gta aaa gat aac atc tat agg aaa ccc cct atc     1409
 Val Pro Asp Thr Gly Val Lys Asp Asn Ile Tyr Arg Lys Pro Pro Ile
             425                 430                 435

 tac aga cag cat gct gcc agg cga tcg gat ggg gag gat gga agc ttg     1457
 Tyr Arg Gln His Ala Ala Arg Arg Ser Asp Gly Glu Asp Gly Ser Leu
         440                 445                 450

 gac cag gat aac agg aag cag aag agc agc tgg ctg atg ctc aag ggg     1505
 Asp Gln Asp Asn Arg Lys Gln Lys Ser Ser Trp Leu Met Leu Lys Gly
     455                 460                 465

 gat gca gac aca agg acc aat tct cca gac ctg gac acc cag tcc ttg     1553
 Asp Ala Asp Thr Arg Thr Asn Ser Pro Asp Leu Asp Thr Gln Ser Leu
 470                 475                 480                 485

 tcc cac agc agc ggg acc gac aga gac cct ctc caa agg atg gca ggg     1601
 Ser His Ser Ser Gly Thr Asp Arg Asp Pro Leu Gln Arg Met Ala Gly
                 490                 495                 500

 gac agc ttt cac tca caa tac aag atc tat ccg tat gac tcc ctc atc     1649
 Asp Ser Phe His Ser Gln Tyr Lys Ile Tyr Pro Tyr Asp Ser Leu Ile
             505                 510                 515

 gtc aca aac cga att cgc gtg aaa ctg ccc aaa gac gtg gac cgg acg     1697
 Val Thr Asn Arg Ile Arg Val Lys Leu Pro Lys Asp Val Asp Arg Thr
         520                 525                 530

 aga ctg gag aga cac ttg tcg ccc gag gag ttc cag gaa gtg ttt ggg     1745
 Arg Leu Glu Arg His Leu Ser Pro Glu Glu Phe Gln Glu Val Phe Gly
     535                 540                 545

 atg agc atc gag gag ttt gac cgc ctg gcc ctc tgg aag agg aat gac     1793
 Met Ser Ile Glu Glu Phe Asp Arg Leu Ala Leu Trp Lys Arg Asn Asp
 550                 555                 560                 565

 ctt aag aag aaa gcc ctt ttg ttc tga cggct gccagcctgc cccactggtg     1845
 Leu Lys Lys Lys Ala Leu Leu Phe 
                 570

 tgtgccgggc gccgaggcca ggggcccctg gcgagaaccg cacacacccc tcccacacac   1905

 cttgctctgg cttctctgtg tccatggggt gggcgggagg gggtccccca gcaggtgcgg   1965

 cccctgcacc tgccggcgac actcctgccg gtagtttagg gccgagacgg ctagcttcac   2025

 gccacccttc cccgctgtgg cttggtgtca gggagaggct gtagagtggc tgtgtcgggc   2085

 atcagatgga gcacacaggt ggcttgcagc ccagcccagc cttcccagcg ttctcgaggt   2145

 gccctggccc cggtgctggg cacgtggggg acagaggtgg ccgggacgtg agctgtgagg   2205

 cttgttgatg acgggtgctg acaccatcat cgggggtggg cacacggccc ttcggagcct   2265

 gggcagcctg gcctcacagg cagactcgca gatggggcag tgagcgtctg ggacagtgcc   2325

 aagagtgggg tgtgtgattt ttgcaggcgt ctgtgatggg tctctttagg gacaaatgtc   2385

 aacaagggac aagacagggc accttccgcc agcgcccctc catgcgctgc gttcctcctc   2445

 cagatcgacc cctagatgcc tacacaatat ctttaaagta acacagaagt ttttatttta   2505

 ttaaaaagta tagcctactt aaacgcgaga tgacatatat agagtttaat tttacggtcc   2565

 ctccgcaggg gagcggcctc cagccttatt ctccaccgct cggatctgtg tggtttcagt   2625

 ctgttcttgg tgtggtcctc atacacagag ctccctgtct agtttctttt ctttttcttt   2685

 tttctttttc tcgtcacaca ggtaacctta aagacagacc cctctaaaga acgctttgta   2745

 aatacatgtg aggtatagcc accactgttt tccttgctgt tatttttcca agtcttgggg   2805

 agaaaacatc ctcctctgat ggccaaagcc ctggaatcaa gggtttccac gtaccctgcc   2865

 taatacccga cgtagctctt gatgcaccgt ccttgtgctg tggctggcgg tgtctcagcc   2925

 tgaaacataa accccacatg ccccaggagc gatgtgctcc ctgaaacaga caaccacacg   2985

 ctgttgggga gagaaggatg gagataggat ggagatagga tggagatgtg gctcttctca   3045

 tctttgaagc cagcagggca tcccggagca ggaggctggc cgggctcccc aagcgaaggc   3105

 gttggtgtct gtcattaggt gtgtgttagg gtgcagcacc ggccgtcaca ggatgctgat   3165

 aagcgcgctg agaggtggat gaaacaccaa agtctgtttc cccgtccgca gtgggtgttg   3225

 cctctttgtg tgtgtcccga tgttcctgcc tgtgagtcgg ccttactccg tttccttagc   3285

 gcccatgaca cgccaagtcc cgtttcgcac tcggcttctc acccgcccag ctcggctagg   3345

 gagggggagt ttttagcacc taatatgctt cctgccattg cgcaatctga gcctgagcaa   3405

 ctggaaaccc ccatttctca ttagtgcaat gtcatatctg atcccaggaa gcctggaaaa   3465

 taaaagacga tgcattataa aaaaaaaaaa aaaa                               3499




      <210> 213
      <211> 4506
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (426)..(2372)

      <400> 213
 gacagcaagg cgtatgtgac cattctctag aatatttaag ctcgagaatc tcagagcgga     60

 agctgcaagg ctcctggctg cctgccagcc gagggaatct ggagaaacca ttcctggggc    120

 cgcgtggccc cgtcgtgccc ttgttctgcc ctcggaatgg ccttcactca gcacatcctg    180

 agaacagccc tctgaagccc agggtcgtga ccgtagtgaa gctgggtggg cagcgccccc    240

 gaaagatcac tctgctcctc aacaggcgat cagtgcagac gttcgagcag ctcttagctg    300

 acatctcaga agccttgggc tctcccagat ggaagaatga ccgtgtgagg aaactgttta    360

 acctcaaggg cagggaaatc aggagcgtct ctgatttctt cagggaaggg gatgctttca    420

 tagct    atg ggc aaa gaa cca ctg aca ctg aag agc att cag gtg gct     467
          Met Gly Lys Glu Pro Leu Thr Leu Lys Ser Ile Gln Val Ala
            1               5                  10

 gta gaa gaa ctg tac ccc aac aaa gcc cgg gcc ctg aca ctg gcc cag      515
 Val Glu Glu Leu Tyr Pro Asn Lys Ala Arg Ala Leu Thr Leu Ala Gln
  15                  20                  25                  30

 cac agc cgt gcc cct tct cca agg ctg agg agc agg ctg ttt agc aag      563
 His Ser Arg Ala Pro Ser Pro Arg Leu Arg Ser Arg Leu Phe Ser Lys
                  35                  40                  45

 gct ctg aaa gga gac cac cgc tgt ggg gag acc gag acc ccc aag agc      611
 Ala Leu Lys Gly Asp His Arg Cys Gly Glu Thr Glu Thr Pro Lys Ser
              50                  55                  60

 tgc agc gaa gtt gca gga tgc aag gca gcc atg agg cac cag ggg aag      659
 Cys Ser Glu Val Ala Gly Cys Lys Ala Ala Met Arg His Gln Gly Lys
          65                  70                  75

 atc ccc gag gag ctt tca cta gat gac aga gcg agg acc cag aag aag      707
 Ile Pro Glu Glu Leu Ser Leu Asp Asp Arg Ala Arg Thr Gln Lys Lys
      80                  85                  90

 tgg ggg agg ggg aaa tgg gag cca gaa ccc agt agc aag ccc ccc agg      755
 Trp Gly Arg Gly Lys Trp Glu Pro Glu Pro Ser Ser Lys Pro Pro Arg
  95                 100                 105                 110

 gaa gcc act ctg gaa gag agg cac gca agg gga gag aag cat ctt ggg      803
 Glu Ala Thr Leu Glu Glu Arg His Ala Arg Gly Glu Lys His Leu Gly
                 115                 120                 125

 gtg gag att gaa aag acc tcg ggt gaa att atc aga tgc gag aag tgc      851
 Val Glu Ile Glu Lys Thr Ser Gly Glu Ile Ile Arg Cys Glu Lys Cys
             130                 135                 140

 aag aga gag agg gag ctt cag cag agc ctg gag cgt gag agg ctt tct      899
 Lys Arg Glu Arg Glu Leu Gln Gln Ser Leu Glu Arg Glu Arg Leu Ser
         145                 150                 155

 ctg ggg acc agt gag ctg gat atg ggg aag ggc cca atg tat gat gtg      947
 Leu Gly Thr Ser Glu Leu Asp Met Gly Lys Gly Pro Met Tyr Asp Val
     160                 165                 170

 gag aag ctg gtg agg acc aga agc tgc agg agg tct ccc gag gca aat      995
 Glu Lys Leu Val Arg Thr Arg Ser Cys Arg Arg Ser Pro Glu Ala Asn
 175                 180                 185                 190

 cct gca agt ggg gag gaa ggg tgg aag ggt gac agc cac agg agc agc     1043
 Pro Ala Ser Gly Glu Glu Gly Trp Lys Gly Asp Ser His Arg Ser Ser
                 195                 200                 205

 ccc agg aat ccc act caa gag ctg agg aga ccc agc aag agc atg gac     1091
 Pro Arg Asn Pro Thr Gln Glu Leu Arg Arg Pro Ser Lys Ser Met Asp
             210                 215                 220

 aag aaa gag gac aga ggc cca gag gat caa gaa agc cat gct cag gga     1139
 Lys Lys Glu Asp Arg Gly Pro Glu Asp Gln Glu Ser His Ala Gln Gly
         225                 230                 235

 gca gcc aag gcc aag aag gac ctt gtg gaa gtt ctt cct gtc aca gag     1187
 Ala Ala Lys Ala Lys Lys Asp Leu Val Glu Val Leu Pro Val Thr Glu
     240                 245                 250

 gag ggg ctg agg gag gtg aag aag gac acc agg ccc atg agc agg agc     1235
 Glu Gly Leu Arg Glu Val Lys Lys Asp Thr Arg Pro Met Ser Arg Ser
 255                 260                 265                 270

 aaa cat ggt ggc tgg ctc ctg aga gag cac cag gcg ggc ttt gag aag     1283
 Lys His Gly Gly Trp Leu Leu Arg Glu His Gln Ala Gly Phe Glu Lys
                 275                 280                 285

 ctc cgc agg acc cga gga gaa gag aag gag gca gag aag gag aaa aag     1331
 Leu Arg Arg Thr Arg Gly Glu Glu Lys Glu Ala Glu Lys Glu Lys Lys
             290                 295                 300

 cca tgt atg tct gga ggc aga agg atg act ctc aga gat gac caa cct     1379
 Pro Cys Met Ser Gly Gly Arg Arg Met Thr Leu Arg Asp Asp Gln Pro
         305                 310                 315

 gca aag cta gaa aag gag ccc aag acg agg cca gaa gag aac aag cca     1427
 Ala Lys Leu Glu Lys Glu Pro Lys Thr Arg Pro Glu Glu Asn Lys Pro
     320                 325                 330

 gag cgg ccc agc ggt cgg aag cca cgg ccc atg ggc atc att gcc gcc     1475
 Glu Arg Pro Ser Gly Arg Lys Pro Arg Pro Met Gly Ile Ile Ala Ala
 335                 340                 345                 350

 aat gtg gaa aag cat tat gag act ggc cgg gtc att ggg gat ggg aac     1523
 Asn Val Glu Lys His Tyr Glu Thr Gly Arg Val Ile Gly Asp Gly Asn
                 355                 360                 365

 ttt gct gtc gtg aag gag tgc aga cac cgc gag acc agg cag gcc tat     1571
 Phe Ala Val Val Lys Glu Cys Arg His Arg Glu Thr Arg Gln Ala Tyr
             370                 375                 380

 gcg atg aag atc att gac aag tcc aga ctc aag ggc aag gag gac atg     1619
 Ala Met Lys Ile Ile Asp Lys Ser Arg Leu Lys Gly Lys Glu Asp Met
         385                 390                 395

 gtg gac agt gag atc ttg atc atc cag agc ctc tct cac ccc aac atc     1667
 Val Asp Ser Glu Ile Leu Ile Ile Gln Ser Leu Ser His Pro Asn Ile
     400                 405                 410

 gtg aaa ttg cat gaa gtc tac gaa aca gac atg gaa atc tac ctg atc     1715
 Val Lys Leu His Glu Val Tyr Glu Thr Asp Met Glu Ile Tyr Leu Ile
 415                 420                 425                 430

 ctg gag tac gtg cag gga gga gac ctt ttt gac gcc atc ata gaa agt     1763
 Leu Glu Tyr Val Gln Gly Gly Asp Leu Phe Asp Ala Ile Ile Glu Ser
                 435                 440                 445

 gtg aag ttc ccg gag ccc gat gct gcc ctc atg atc atg gac tta tgc     1811
 Val Lys Phe Pro Glu Pro Asp Ala Ala Leu Met Ile Met Asp Leu Cys
             450                 455                 460

 aaa gcc ctc gtc cac atg cac gac aag agc att gtc cac cgg gac ctc     1859
 Lys Ala Leu Val His Met His Asp Lys Ser Ile Val His Arg Asp Leu
         465                 470                 475

 aag ccg gaa aac ctt ttg gtt cag cga aat gag gac aaa tct act acc     1907
 Lys Pro Glu Asn Leu Leu Val Gln Arg Asn Glu Asp Lys Ser Thr Thr
     480                 485                 490

 ttg aaa ttg gct gat ttt gga ctt gca aag cat gtg gtg aga cct ata     1955
 Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys His Val Val Arg Pro Ile
 495                 500                 505                 510

 ttt act gtg tgt ggg acc cca act tac gta gct ccc gaa att ctt tct     2003
 Phe Thr Val Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Leu Ser
                 515                 520                 525

 gag aaa ggt tat gga ctg gag gtg gac atg tgg gct gct ggc gtg atc     2051
 Glu Lys Gly Tyr Gly Leu Glu Val Asp Met Trp Ala Ala Gly Val Ile
             530                 535                 540

 ctc tat atc ctg ctg tgt ggc ttt ccc cca ttc cgc agc cct gag agg     2099
 Leu Tyr Ile Leu Leu Cys Gly Phe Pro Pro Phe Arg Ser Pro Glu Arg
         545                 550                 555

 gac cag gac gag ctc ttt aac atc atc cag ctg ggc cac ttt gag ttc     2147
 Asp Gln Asp Glu Leu Phe Asn Ile Ile Gln Leu Gly His Phe Glu Phe
     560                 565                 570

 ctc ccc cct tac tgg gac aat atc tct gat gct gct aaa gat ctg gtg     2195
 Leu Pro Pro Tyr Trp Asp Asn Ile Ser Asp Ala Ala Lys Asp Leu Val
 575                 580                 585                 590

 agc cgg ttg ctg gtg gta gac ccc aaa aag cgc tac aca gct cat cag     2243
 Ser Arg Leu Leu Val Val Asp Pro Lys Lys Arg Tyr Thr Ala His Gln
                 595                 600                 605

 gtt ctt cag cac ccc tgg atc gaa aca gct ggc aag acc aat aca gtg     2291
 Val Leu Gln His Pro Trp Ile Glu Thr Ala Gly Lys Thr Asn Thr Val
             610                 615                 620

 aaa cga cag aag cag gtg tcc ccc agc agc gag ggt cac ttc cgg agc     2339
 Lys Arg Gln Lys Gln Val Ser Pro Ser Ser Glu Gly His Phe Arg Ser
         625                 630                 635

 cag cac aag agg gtt gtg gag cag gta tca tag tcaccacc ttgggaatct     2390
 Gln His Lys Arg Val Val Glu Gln Val Ser 
     640                 645

 gtccagcccc cagttctgct caaggacaga gaaaaggata gaagtttgag agaaaaacaa   2450

 tgaaagaggc ttcttcacat aattggtgaa tcagagggag agacactgag tatattttaa   2510

 agcatattaa aaaaattaag tcaatgttaa atgtcacaac atatttttag atttgtatat   2570

 ttaaagcctt taatacattt ttggggggta agcattgtca tcagtgagga attttggtaa   2630

 taatgatgtg ttttgcttcc cctttgtaac caagtttatt ctgtactaca ggagtggtgc   2690

 ttaccagggt ctaaactccc cctgtgagat taataaggtg cattgtggtc tttctgtgtt   2750

 aataaaatgt gctctgaata acagaagtgg gcctgtattc tgattacttc tttgtgctgg   2810

 tgatgacagc cagggaatga attatagttc aggcatatct cctgaagctg atatgactac   2870

 atatagatgt gaaggacact tgattagttg acaagacctg tttatttagg atgcactaat   2930

 cttggtctct tgcatttcag tcttaccaaa aatcagtttt ggtgcagtct gagacatgga   2990

 aagaaaaaaa acaaaccatt gaatcattct tgctcctgca ataccgttat actgcttttc   3050

 agccccaatt atccctgagc ctgagtcatt tctatgtgaa gtcaggcgct caggctgtga   3110

 ccgtgttaac attttcagat cacgagggag ccatttagta cattcatatg tcagaaatgc   3170

 agtaaatgga ttacactggg gctccaagga gctcagagtt caagcacaat cctacctgca   3230

 gggcatacac ccaggacaca ttccagattt ctgtgctgaa atattggtct ttgcagatga   3290

 ttctgggagt ctgtgtgagc tgacagcaag acatatccta atatttccca aattgacctt   3350

 cctagattat gaatgacctg gttagtaggc cacaaaatct agtcaagagt gtggcttttt   3410

 cacgtctacc ttccctaaca gttttggagc catctgggcg gaggcgtgtg ttagttagga   3470

 aaaccggaac agtactagag aattcaacat aaggaattgc ttaatcaggt tttggaaaat   3530

 ggaagaagca caaaggaggc tctggtataa tttagagata gtaactgcag gaagtggctc   3590

 ctgttctttg gagaaccaag ggaagaagtt ggggttatta gaacctattg aaggagaaat   3650

 ttcttgtagt ggacactgta gtatgccact caggtcctcc aagactgaag ggaataagct   3710

 ccttggggtg ctgctggatg atggctctca gctttcagcc ctctacagga attaccctcc   3770

 actggaagag acacctttca gctccctcct gaagcaggct atatcaaatg actagtccct   3830

 gtagggtatg gtggctcagc tcctttgtcc caaacaggga caatactgaa gggccatcca   3890

 actacggacc tgcccatggg ggttggctga actgttggtt gagactgcat catagcccac   3950

 tttctccctt gcccaatcct gcttctttcc tttcccttcc agaggtaatg atcctgagac   4010

 cactccctaa taagcctttt ggatgctaat ctggatttta gagttggctt ctcgggaaac   4070

 caaaccgttg acacccccta gaaacttgaa accacatcaa agaagtacca gctggtgctt   4130

 taacctcaga agcttggaga aggggccctg tggagcaggg actcagaccc ctgaggagtg   4190

 ggtgctgccc agcaggcagt gtaatgggac tcattctgaa cacgtgaaag aggctggaag   4250

 ctggattcag ttgctactag aacatatttt gataaagaca ccagtaacct tcatttcact   4310

 aaatccaaaa gagaattttc aatcctcaaa ttagcatcac ttgaccctat tgaccacttt   4370

 ctctttgaat aatttctcct gttgactacc atgatgtcac atttttctgg tttttttttc   4430

 tcctatacct ttggatctct tgtatagatt cagtcttctt ccagttgcta aaagctgtag   4490

 ttccatcctt agtggc                                                   4506




      <210> 214
      <211> 4652
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (11)..(2518)

      <400> 214
 cctcacaatc   atg gcg gaa ggc aag gaa ggg caa gtc cca tct tac atg      49
              Met Ala Glu Gly Lys Glu Gly Gln Val Pro Ser Tyr Met
                1               5                  10

 gat ggc agc agg caa aga gag aat gag gaa gat gca aaa gcg gaa acc       97
 Asp Gly Ser Arg Gln Arg Glu Asn Glu Glu Asp Ala Lys Ala Glu Thr
      15                  20                  25

 cct gat gta acc atc aga tct tat gag att tat tca cta cca tgg aac      145
 Pro Asp Val Thr Ile Arg Ser Tyr Glu Ile Tyr Ser Leu Pro Trp Asn
  30                  35                  40                  45

 aga cag caa ggc gta tgt gac cat tct cta gaa tat tta agc tcg aga      193
 Arg Gln Gln Gly Val Cys Asp His Ser Leu Glu Tyr Leu Ser Ser Arg
                  50                  55                  60

 atc tca gag cgg aag ctg caa ggc tcc tgg ctg cct gcc agc cga ggg      241
 Ile Ser Glu Arg Lys Leu Gln Gly Ser Trp Leu Pro Ala Ser Arg Gly
              65                  70                  75

 aat ctg gag aaa cca ttc ctg ggg ccg cgt ggc ccc gtc gtg ccc ttg      289
 Asn Leu Glu Lys Pro Phe Leu Gly Pro Arg Gly Pro Val Val Pro Leu
          80                  85                  90

 ttc tgc cct cgg aat ggc ctt cac tca gca cat cct gag aac agc cct      337
 Phe Cys Pro Arg Asn Gly Leu His Ser Ala His Pro Glu Asn Ser Pro
      95                 100                 105

 ctg aag ccc agg gtc gtg acc gta gtg aag ctg ggt ggg cag cgc ccc      385
 Leu Lys Pro Arg Val Val Thr Val Val Lys Leu Gly Gly Gln Arg Pro
 110                 115                 120                 125

 cga aag atc act ctg ctc ctc aac agg cga tca gtg cag acg ttc gag      433
 Arg Lys Ile Thr Leu Leu Leu Asn Arg Arg Ser Val Gln Thr Phe Glu
                 130                 135                 140

 cag ctc tta gct gac atc tca gaa gcc ttg ggc tct ccc aga tgg aag      481
 Gln Leu Leu Ala Asp Ile Ser Glu Ala Leu Gly Ser Pro Arg Trp Lys
             145                 150                 155

 aat gac cgt gtg agg aaa ctg ttt aac ctc aag ggc agg gaa atc agg      529
 Asn Asp Arg Val Arg Lys Leu Phe Asn Leu Lys Gly Arg Glu Ile Arg
         160                 165                 170

 agc gtc tct gat ttc ttc agg gaa ggg gat gct ttc ata gct atg ggc      577
 Ser Val Ser Asp Phe Phe Arg Glu Gly Asp Ala Phe Ile Ala Met Gly
     175                 180                 185

 aaa gaa cca ctg aca ctg aag agc att cag gtg gct gta gaa gaa ctg      625
 Lys Glu Pro Leu Thr Leu Lys Ser Ile Gln Val Ala Val Glu Glu Leu
 190                 195                 200                 205

 tac ccc aac aaa gcc cgg gcc ctg aca ctg gcc cag cac agc cgt gcc      673
 Tyr Pro Asn Lys Ala Arg Ala Leu Thr Leu Ala Gln His Ser Arg Ala
                 210                 215                 220

 cct tct cca agg ctg agg agc agg ctg ttt agc aag gct ctg aaa gga      721
 Pro Ser Pro Arg Leu Arg Ser Arg Leu Phe Ser Lys Ala Leu Lys Gly
             225                 230                 235

 gac cac cgc tgt ggg gag acc gag acc ccc aag agc tgc agc gaa gtt      769
 Asp His Arg Cys Gly Glu Thr Glu Thr Pro Lys Ser Cys Ser Glu Val
         240                 245                 250

 gca gga tgc aag gca gcc atg agg cac cag ggg aag atc ccc gag gag      817
 Ala Gly Cys Lys Ala Ala Met Arg His Gln Gly Lys Ile Pro Glu Glu
     255                 260                 265

 ctt tca cta gat gac aga gcg agg acc cag aag aag tgg ggg agg ggg      865
 Leu Ser Leu Asp Asp Arg Ala Arg Thr Gln Lys Lys Trp Gly Arg Gly
 270                 275                 280                 285

 aaa tgg gag cca gaa ccc agt agc aag ccc ccc agg gaa gcc act ctg      913
 Lys Trp Glu Pro Glu Pro Ser Ser Lys Pro Pro Arg Glu Ala Thr Leu
                 290                 295                 300

 gaa gag agg cac gca agg gga gag aag cat ctt ggg gtg gag att gaa      961
 Glu Glu Arg His Ala Arg Gly Glu Lys His Leu Gly Val Glu Ile Glu
             305                 310                 315

 aag acc tcg ggt gaa att atc aga tgc gag aag tgc aag aga gag agg     1009
 Lys Thr Ser Gly Glu Ile Ile Arg Cys Glu Lys Cys Lys Arg Glu Arg
         320                 325                 330

 gag ctt cag cag agc ctg gag cgt gag agg ctt tct ctg ggg acc agt     1057
 Glu Leu Gln Gln Ser Leu Glu Arg Glu Arg Leu Ser Leu Gly Thr Ser
     335                 340                 345

 gag ctg gat atg ggg aag ggc cca atg tat gat gtg gag aag ctg gtg     1105
 Glu Leu Asp Met Gly Lys Gly Pro Met Tyr Asp Val Glu Lys Leu Val
 350                 355                 360                 365

 agg acc aga agc tgc agg agg tct ccc gag gca aat cct gca agt ggg     1153
 Arg Thr Arg Ser Cys Arg Arg Ser Pro Glu Ala Asn Pro Ala Ser Gly
                 370                 375                 380

 gag gaa ggg tgg aag ggt gac agc cac agg agc agc ccc agg aat ccc     1201
 Glu Glu Gly Trp Lys Gly Asp Ser His Arg Ser Ser Pro Arg Asn Pro
             385                 390                 395

 act caa gag ctg agg aga ccc agc aag agc atg gac aag aaa gag gac     1249
 Thr Gln Glu Leu Arg Arg Pro Ser Lys Ser Met Asp Lys Lys Glu Asp
         400                 405                 410

 aga ggc cca gag gat caa gaa agc cat gct cag gga gca gcc aag gcc     1297
 Arg Gly Pro Glu Asp Gln Glu Ser His Ala Gln Gly Ala Ala Lys Ala
     415                 420                 425

 aag aag gac ctt gtg gaa gtt ctt cct gtc aca gag gag ggg ctg agg     1345
 Lys Lys Asp Leu Val Glu Val Leu Pro Val Thr Glu Glu Gly Leu Arg
 430                 435                 440                 445

 gag gtg aag aag gac acc agg ccc atg agc agg agc aaa cat ggt ggc     1393
 Glu Val Lys Lys Asp Thr Arg Pro Met Ser Arg Ser Lys His Gly Gly
                 450                 455                 460

 tgg ctc ctg aga gag cac cag gcg ggc ttt gag aag ctc cgc agg acc     1441
 Trp Leu Leu Arg Glu His Gln Ala Gly Phe Glu Lys Leu Arg Arg Thr
             465                 470                 475

 cga gga gaa gag aag gag gca gag aag gag aaa aag cca tgt atg tct     1489
 Arg Gly Glu Glu Lys Glu Ala Glu Lys Glu Lys Lys Pro Cys Met Ser
         480                 485                 490

 gga ggc aga agg atg act ctc aga gat gac caa cct gca aag cta gaa     1537
 Gly Gly Arg Arg Met Thr Leu Arg Asp Asp Gln Pro Ala Lys Leu Glu
     495                 500                 505

 aag gag ccc aag acg agg cca gaa gag aac aag cca gag cgg ccc agc     1585
 Lys Glu Pro Lys Thr Arg Pro Glu Glu Asn Lys Pro Glu Arg Pro Ser
 510                 515                 520                 525

 ggt cgg aag cca cgg ccc atg ggc atc att gcc gcc aat gtg gaa aag     1633
 Gly Arg Lys Pro Arg Pro Met Gly Ile Ile Ala Ala Asn Val Glu Lys
                 530                 535                 540

 cat tat gag act ggc cgg gtc att ggg gat ggg aac ttt gct gtc gtg     1681
 His Tyr Glu Thr Gly Arg Val Ile Gly Asp Gly Asn Phe Ala Val Val
             545                 550                 555

 aag gag tgc aga cac cgc gag acc agg cag gcc tat gcg atg aag atc     1729
 Lys Glu Cys Arg His Arg Glu Thr Arg Gln Ala Tyr Ala Met Lys Ile
         560                 565                 570

 att gac aag tcc aga ctc aag ggc aag gag gac atg gtg gac agt gag     1777
 Ile Asp Lys Ser Arg Leu Lys Gly Lys Glu Asp Met Val Asp Ser Glu
     575                 580                 585

 atc ttg atc atc cag agc ctc tct cac ccc aac atc gtg aaa ttg cat     1825
 Ile Leu Ile Ile Gln Ser Leu Ser His Pro Asn Ile Val Lys Leu His
 590                 595                 600                 605

 gaa gtc tac gaa aca gac atg gaa atc tac ctg atc ctg gag tac gtg     1873
 Glu Val Tyr Glu Thr Asp Met Glu Ile Tyr Leu Ile Leu Glu Tyr Val
                 610                 615                 620

 cag gga gga gac ctt ttt gac gcc atc ata gaa agt gtg aag ttc ccg     1921
 Gln Gly Gly Asp Leu Phe Asp Ala Ile Ile Glu Ser Val Lys Phe Pro
             625                 630                 635

 gag ccc gat gct gcc ctc atg atc atg gac tta tgc aaa gcc ctc gtc     1969
 Glu Pro Asp Ala Ala Leu Met Ile Met Asp Leu Cys Lys Ala Leu Val
         640                 645                 650

 cac atg cac gac aag agc att gtc cac cgg gac ctc aag ccg gaa aac     2017
 His Met His Asp Lys Ser Ile Val His Arg Asp Leu Lys Pro Glu Asn
     655                 660                 665

 ctt ttg gtt cag cga aat gag gac aaa tct act acc ttg aaa ttg gct     2065
 Leu Leu Val Gln Arg Asn Glu Asp Lys Ser Thr Thr Leu Lys Leu Ala
 670                 675                 680                 685

 gat ttt gga ctt gca aag cat gtg gtg aga cct ata ttt act gtg tgt     2113
 Asp Phe Gly Leu Ala Lys His Val Val Arg Pro Ile Phe Thr Val Cys
                 690                 695                 700

 ggg acc cca act tac gta gct ccc gaa att ctt tct gag aaa ggt tat     2161
 Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Leu Ser Glu Lys Gly Tyr
             705                 710                 715

 gga ctg gag gtg gac atg tgg gct gct ggc gtg atc ctc tat atc ctg     2209
 Gly Leu Glu Val Asp Met Trp Ala Ala Gly Val Ile Leu Tyr Ile Leu
         720                 725                 730

 ctg tgt ggc ttt ccc cca ttc cgc agc cct gag agg gac cag gac gag     2257
 Leu Cys Gly Phe Pro Pro Phe Arg Ser Pro Glu Arg Asp Gln Asp Glu
     735                 740                 745

 ctc ttt aac atc atc cag ctg ggc cac ttt gag ttc ctc ccc cct tac     2305
 Leu Phe Asn Ile Ile Gln Leu Gly His Phe Glu Phe Leu Pro Pro Tyr
 750                 755                 760                 765

 tgg gac aat atc tct gat gct gct aaa gat ctg gtg agc cgg ttg ctg     2353
 Trp Asp Asn Ile Ser Asp Ala Ala Lys Asp Leu Val Ser Arg Leu Leu
                 770                 775                 780

 gtg gta gac ccc aaa aag cgc tac aca gct cat cag gtt ctt cag cac     2401
 Val Val Asp Pro Lys Lys Arg Tyr Thr Ala His Gln Val Leu Gln His
             785                 790                 795

 ccc tgg atc gaa aca gct ggc aag acc aat aca gtg aaa cga cag aag     2449
 Pro Trp Ile Glu Thr Ala Gly Lys Thr Asn Thr Val Lys Arg Gln Lys
         800                 805                 810

 cag gtg tcc ccc agc agc gag ggt cac ttc cgg agc cag cac aag agg     2497
 Gln Val Ser Pro Ser Ser Glu Gly His Phe Arg Ser Gln His Lys Arg
     815                 820                 825

 gtt gtg gag cag gta tca tag tc accaccttgg gaatctgtcc agcccccagt     2550
 Val Val Glu Gln Val Ser 
 830                 835

 tctgctcaag gacagagaaa aggatagaag tttgagagaa aaacaatgaa agaggcttct   2610

 tcacataatt ggtgaatcag agggagagac actgagtata ttttaaagca tattaaaaaa   2670

 attaagtcaa tgttaaatgt cacaacatat ttttagattt gtatatttaa agcctttaat   2730

 acatttttgg ggggtaagca ttgtcatcag tgaggaattt tggtaataat gatgtgtttt   2790

 gcttcccctt tgtaaccaag tttattctgt actacaggag tggtgcttac cagggtctaa   2850

 actccccctg tgagattaat aaggtgcatt gtggtctttc tgtgttaata aaatgtgctc   2910

 tgaataacag aagtgggcct gtattctgat tacttctttg tgctggtgat gacagccagg   2970

 gaatgaatta tagttcaggc atatctcctg aagctgatat gactacatat agatgtgaag   3030

 gacacttgat tagttgacaa gacctgttta tttaggatgc actaatcttg gtctcttgca   3090

 tttcagtctt accaaaaatc agttttggtg cagtctgaga catggaaaga aaaaaaacaa   3150

 accattgaat cattcttgct cctgcaatac cgttatactg cttttcagcc ccaattatcc   3210

 ctgagcctga gtcatttcta tgtgaagtca ggcgctcagg ctgtgaccgt gttaacattt   3270

 tcagatcacg agggagccat ttagtacatt catatgtcag aaatgcagta aatggattac   3330

 actggggctc caaggagctc agagttcaag cacaatccta cctgcagggc atacacccag   3390

 gacacattcc agatttctgt gctgaaatat tggtctttgc agatgattct gggagtctgt   3450

 gtgagctgac agcaagacat atcctaatat ttcccaaatt gaccttccta gattatgaat   3510

 gacctggtta gtaggccaca aaatctagtc aagagtgtgg ctttttcacg tctaccttcc   3570

 ctaacagttt tggagccatc tgggcggagg cgtgtgttag ttaggaaaac cggaacagta   3630

 ctagagaatt caacataagg aattgcttaa tcaggttttg gaaaatggaa gaagcacaaa   3690

 ggaggctctg gtataattta gagatagtaa ctgcaggaag tggctcctgt tctttggaga   3750

 accaagggaa gaagttgggg ttattagaac ctattgaagg agaaatttct tgtagtggac   3810

 actgtagtat gccactcagg tcctccaaga ctgaagggaa taagctcctt ggggtgctgc   3870

 tggatgatgg ctctcagctt tcagccctct acaggaatta ccctccactg gaagagacac   3930

 ctttcagctc cctcctgaag caggctatat caaatgacta gtccctgtag ggtatggtgg   3990

 ctcagctcct ttgtcccaaa cagggacaat actgaagggc catccaacta cggacctgcc   4050

 catgggggtt ggctgaactg ttggttgaga ctgcatcata gcccactttc tcccttgccc   4110

 aatcctgctt ctttcctttc ccttccagag gtaatgatcc tgagaccact ccctaataag   4170

 ccttttggat gctaatctgg attttagagt tggcttctcg ggaaaccaaa ccgttgacac   4230

 cccctagaaa cttgaaacca catcaaagaa gtaccagctg gtgctttaac ctcagaagct   4290

 tggagaaggg gccctgtgga gcagggactc agacccctga ggagtgggtg ctgcccagca   4350

 ggcagtgtaa tgggactcat tctgaacacg tgaaagaggc tggaagctgg attcagttgc   4410

 tactagaaca tattttgata aagacaccag taaccttcat ttcactaaat ccaaaagaga   4470

 attttcaatc ctcaaattag catcacttga ccctattgac cactttctct ttgaataatt   4530

 tctcctgttg actaccatga tgtcacattt ttctggtttt tttttctcct atacctttgg   4590

 atctcttgta tagattcagt cttcttccag ttgctaaaag ctgtagttcc atccttagtg   4650

 gc                                                                  4652




      <210> 215
      <211> 2492
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (403)..(1536)

      <220>
      <221> misc_feature
      <222> (1)...(2492)
      <223> n = a,t,c or g

      <400> 215
 cctgtactga ctctaggaag ggctggagtt gttttgaatg ggcgcccgta agagaggtgg     60

 gcaagtacgt gttacagacg gccacgccgc cctttaggcg gtcaaggtgg ggcgagcaga    120

 cgttcgcccc cctgcagtcg gccgggtcac tacccaagag cctttggagg cggaagcatg    180

 gaacggtctg caaacgttcc cgagcgggcc tctggcggct ctggcgggcg tttcgaactt    240

 gggcgccggg cacacgccca gtcccgagag cgctgagggt tcccttagcg tcgccctcac    300

 cccggccaac ccgcggggcg ccagagtcct ggccctttaa acgccgcgcg tgcctcggcg    360

 tcttcgtttc gcgcgcccgc ccgcggcgcc ggcggagcga ac   atg gac ccg gct     414
                                                  Met Asp Pro Ala
                                                    1

 gcg cgg gtg gtg cgg gcg ctg tgg cct ggt ggg tgc gcc ttg gcc tgg      462
 Ala Arg Val Val Arg Ala Leu Trp Pro Gly Gly Cys Ala Leu Ala Trp
   5                  10                  15                  20

 agg ctg gga ggc cgc ccc cag ccg ctg cta ccc acg cag agc cgg gct      510
 Arg Leu Gly Gly Arg Pro Gln Pro Leu Leu Pro Thr Gln Ser Arg Ala
                  25                  30                  35

 ggc ttc gcg ggg gcg gcg ggc ggc ccg agc ccc gtg gct gca gct cgt      558
 Gly Phe Ala Gly Ala Ala Gly Gly Pro Ser Pro Val Ala Ala Ala Arg
              40                  45                  50

 aag ggg agc ccg cgg ctg ctg gga gct gcg gcg ctg gcc ctg ggg gga      606
 Lys Gly Ser Pro Arg Leu Leu Gly Ala Ala Ala Leu Ala Leu Gly Gly
          55                  60                  65

 gcc ctg ggg ctg tac cac acg gcg cgg tgg cac ctg cgc gcc cag gac      654
 Ala Leu Gly Leu Tyr His Thr Ala Arg Trp His Leu Arg Ala Gln Asp
      70                  75                  80

 ctc cac gca gag cgc tca gcc gcg cag ctc tcc ctg tcc agc cgc ctg      702
 Leu His Ala Glu Arg Ser Ala Ala Gln Leu Ser Leu Ser Ser Arg Leu
  85                  90                  95                 100

 cag ctg acc ctg tac cag tac aag acg tgt ccc ttc tgc agc aag gtc      750
 Gln Leu Thr Leu Tyr Gln Tyr Lys Thr Cys Pro Phe Cys Ser Lys Val
                 105                 110                 115

 cga gcc ttc ctc gac ttc cat gcc ctg ccc tac cag gtg gtg gag gtg      798
 Arg Ala Phe Leu Asp Phe His Ala Leu Pro Tyr Gln Val Val Glu Val
             120                 125                 130

 aac cct gtg cgc agg gct gag atc aag ttc tcc tcc tac aga aag gtg      846
 Asn Pro Val Arg Arg Ala Glu Ile Lys Phe Ser Ser Tyr Arg Lys Val
         135                 140                 145

 ccc atc ctg gtg gcc cag gaa gga gaa agc tcg caa caa cta aat gac      894
 Pro Ile Leu Val Ala Gln Glu Gly Glu Ser Ser Gln Gln Leu Asn Asp
     150                 155                 160

 tcc tct gtc atc atc agc gcc ctc aag acc tac ctg gtg tcg ggg cag      942
 Ser Ser Val Ile Ile Ser Ala Leu Lys Thr Tyr Leu Val Ser Gly Gln
 165                 170                 175                 180

 ccc ctg gaa gag atc atc acc tac tac cca gcc atg aag gct gtg aac      990
 Pro Leu Glu Glu Ile Ile Thr Tyr Tyr Pro Ala Met Lys Ala Val Asn
                 185                 190                 195

 gag cag ggc aag gag gtg acc gag ttc ggc aat aag tac tgg ctc atg     1038
 Glu Gln Gly Lys Glu Val Thr Glu Phe Gly Asn Lys Tyr Trp Leu Met
             200                 205                 210

 ctc aac gag aag gag gcc cag caa gtg tat ggt ggg aag gag gcc agg     1086
 Leu Asn Glu Lys Glu Ala Gln Gln Val Tyr Gly Gly Lys Glu Ala Arg
         215                 220                 225

 acg gag gag atg aag tgg cgg cag tgg gcg gac gac tgg ctg gtg cac     1134
 Thr Glu Glu Met Lys Trp Arg Gln Trp Ala Asp Asp Trp Leu Val His
     230                 235                 240

 ctg atc tcc ccc aat gtg tac cgc acg ccc acc gag gct ctg gcg tcc     1182
 Leu Ile Ser Pro Asn Val Tyr Arg Thr Pro Thr Glu Ala Leu Ala Ser
 245                 250                 255                 260

 ttt gac tac att gtc cgc gag ggc aag ttc gga gcc gtg gag ggt gcc     1230
 Phe Asp Tyr Ile Val Arg Glu Gly Lys Phe Gly Ala Val Glu Gly Ala
                 265                 270                 275

 gtg gcc aag tac atg ggt gca gcg gcc atg tac ctc atc agc aag cga     1278
 Val Ala Lys Tyr Met Gly Ala Ala Ala Met Tyr Leu Ile Ser Lys Arg
             280                 285                 290

 ctc aag agc agg cac cgc ctc cag gac aac gtg cgc gag gac ctc tat     1326
 Leu Lys Ser Arg His Arg Leu Gln Asp Asn Val Arg Glu Asp Leu Tyr
         295                 300                 305

 gag gct gct gac aag tgg gtg gct gct gtg ggc aag gac cgg ccc ttc     1374
 Glu Ala Ala Asp Lys Trp Val Ala Ala Val Gly Lys Asp Arg Pro Phe
     310                 315                 320

 atg ggg ggc cag aag ccg aat ctc gct gat ttg gcg gtg tat ggc gtg     1422
 Met Gly Gly Gln Lys Pro Asn Leu Ala Asp Leu Ala Val Tyr Gly Val
 325                 330                 335                 340

 ctg cgt gtg atg gag ggg ctg gat gca ttc gat gac ctg atg cag cac     1470
 Leu Arg Val Met Glu Gly Leu Asp Ala Phe Asp Asp Leu Met Gln His
                 345                 350                 355

 acg cac atc cag ccc tgg tac ctg cgg gtg gag agg gcc atc acc gag     1518
 Thr His Ile Gln Pro Trp Tyr Leu Arg Val Glu Arg Ala Ile Thr Glu
             360                 365                 370

 gcc tcc cca gcg cac tga atgtcc ccgcgcagag cagagggaag gcagcggaag     1572
 Ala Ser Pro Ala His 
         375

 acgccagctg ccagggcctg gggccactgg gccagcgcct ggcgatactg gttgggggca   1632

 ggatcattct gccccttgtc cacgcacccc caccagccct ctcgcttcta acacagggca   1692

 cctgctgggg ctcagggatg ttagggacga gttccagccc tgccactgcc ctggggcgac   1752

 ccctccctgt ccctgcctcc ctgctctgcc gcccctcttc ctggaccctc agtggctgtc   1812

 ccatggctac atcctgtggg tgggggccct cgacaggaca gcaggacggt ttgttttcag   1872

 tggaatccca tccctgggtt cccctggttc ccactcttcc caagcctccc nnnnnnnnnn   1932

 nnnnnnnnnn nnnaaggaaa ggtttgtggc gcctgtcatg gcaggcatct catggacaaa   1992

 aaaaacactg agaacacaga aagaaaaaac acggttgggc cgcctgctgg cccgtgaaag   2052

 aggttcaaaa acccattggt tgggcgcccg ggcccaatca ggtagcgcac acggggcaag   2112

 cgggccaagg aaacccgcgc agacagacga ggggggcata cacccaaata aaacggcggg   2172

 ggaccacggg cttcggacca aacccgaggg aacgggggcc acaggggaac acacagaggg   2232

 tcacggagcg aatatccgca caggagagag gaaaggcgca agcacatcaa cacgcggcag   2292

 gaccagacag ggacgagggg cgagggggag cggccggcga cacgagcgcg aagacaaaca   2352

 agcagggacg accagcggca ctcacaagga acacgcgagc ggggtggcga cgagaaggca   2412

 aagcaaatca gggcgtgagg acacgcgggg acggacgaga aacggcacac cgacgggaca   2472

 ccgcccgcag cccacaaaaa                                               2492




      <210> 216
      <211> 959
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (13)..(750)

      <400> 216
 ggcagaggca tc    atg gag ggt ccc cgg gga tgg ctg gtg ctc tct gtg      48
                  Met Glu Gly Pro Arg Gly Trp Leu Val Leu Ser Val
                    1               5                  10

 ctg gcc ata tcg ctg gcc tct atg gtg acc gag gac ttg tgc cga gca       96
 Leu Ala Ile Ser Leu Ala Ser Met Val Thr Glu Asp Leu Cys Arg Ala
          15                  20                  25

 cca gac ggg aag aaa ggg gag gca gga aga cct ggc aga cgg ggg cgg      144
 Pro Asp Gly Lys Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg
      30                  35                  40

 cca ggc ctc aag ggg gag caa ggg gag ccg ggg gcc cct ggc atc cgg      192
 Pro Gly Leu Lys Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg
  45                  50                  55                  60

 aca ggc atc caa ggc ctt aaa gga gac cag ggg gaa cct ggg ccc tct      240
 Thr Gly Ile Gln Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser
                  65                  70                  75

 gga aac ccc ggc aag gtg ggc tac cca ggg ccc agc ggc ccc ctc gga      288
 Gly Asn Pro Gly Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly
              80                  85                  90

 gcc cgt ggc atc ccg gga att aaa ggc acc aag ggc agc cca gga aac      336
 Ala Arg Gly Ile Pro Gly Ile Lys Gly Thr Lys Gly Ser Pro Gly Asn
          95                 100                 105

 atc aag gac cag ccg agg cca gcc ttc tcc gcc att cgg cgg aac ccc      384
 Ile Lys Asp Gln Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro
     110                 115                 120

 cca atg ggg ggc aac gtg gtc atc ttc gac acg gtc atc acc aac cag      432
 Pro Met Gly Gly Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln
 125                 130                 135                 140

 gaa gaa ccg tac cag aac cac tcc ggc cga ttc gtc tgc act gta ccc      480
 Glu Glu Pro Tyr Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro
                 145                 150                 155

 ggc tac tac tac ttc acc ttc cag gtg ctg tcc cag tgg gaa atc tgc      528
 Gly Tyr Tyr Tyr Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys
             160                 165                 170

 ctg tcc atc gtc tcc tcc tca agg ggc cag gtc cga cgc tcc ctg ggc      576
 Leu Ser Ile Val Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly
         175                 180                 185

 ttc tgt gac acc acc aac aag ggg ctc ttc cag gtg gtg tca ggg ggc      624
 Phe Cys Asp Thr Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly
     190                 195                 200

 atg gtg ctt cag ctg cag cag ggt gac cag gtc tgg gtt gaa aaa gac      672
 Met Val Leu Gln Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp
 205                 210                 215                 220

 ccc aaa aag ggt cac att tac cag ggc tct gag gcc gac agc gtc ttc      720
 Pro Lys Lys Gly His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe
                 225                 230                 235

 agc ggc ttc ctc atc ttc cca tct gcc tga g ccagggaagg accccctccc      771
 Ser Gly Phe Leu Ile Phe Pro Ser Ala 
             240                 245

 ccacccacct ctctggcttc catgctccgc ctgtaaaatg ggggcgctat tgcttcagct    831

 gctgaaggga gggggctggc tctgagagcc ccaggactgg ctgccccgtg acacatgctc    891

 taagaagctc gtttcttaga cctcttcctg gaataaacat ctgtgtctgt gtctgctgaa    951

 aaaaaaaa                                                             959




      <210> 217
      <211> 876
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(692)

      <400> 217
 ggcagcggcg cttcctggtg gtcagggcgc cc  atg gcg ctg tcc tgg ctg cag      53
                                      Met Ala Leu Ser Trp Leu Gln
                                        1               5

 cgc gtc gag ctt gcg ctc ttt gct gcc gcc ttc ctg tgc ggg gcc gtg      101
 Arg Val Glu Leu Ala Leu Phe Ala Ala Ala Phe Leu Cys Gly Ala Val
          10                  15                  20

 gcg gcc gcg gcg atg act cgg acc cag ggc tcc ttc agt ggt aga tgt      149
 Ala Ala Ala Ala Met Thr Arg Thr Gln Gly Ser Phe Ser Gly Arg Cys
      25                  30                  35

 ccc ctg tat ggt gtg gcc acc ctg aat ggc tcc tcc ctg gcc tta tcc      197
 Pro Leu Tyr Gly Val Ala Thr Leu Asn Gly Ser Ser Leu Ala Leu Ser
  40                  45                  50                  55

 cgt ccc tca gca cca tcc ctg tgc tac ttt gta gct ggg gcc tct ggc      245
 Arg Pro Ser Ala Pro Ser Leu Cys Tyr Phe Val Ala Gly Ala Ser Gly
                  60                  65                  70

 ctc ttg gcc ctc tac tgc ctc ctg ctt ttg ctc ttc tgg atc tac agc      293
 Leu Leu Ala Leu Tyr Cys Leu Leu Leu Leu Leu Phe Trp Ile Tyr Ser
              75                  80                  85

 agc tgc atc gag gac tcc cac aga ggt gct ata ggg ctg cgc att gca      341
 Ser Cys Ile Glu Asp Ser His Arg Gly Ala Ile Gly Leu Arg Ile Ala
          90                  95                 100

 ctg gcc atc tca gct ata gcc gtc ttc ctg gtc ttg gtg tct gcc tgt      389
 Leu Ala Ile Ser Ala Ile Ala Val Phe Leu Val Leu Val Ser Ala Cys
     105                 110                 115

 atc ctt cga ttt ggc acc agg tct ctc tgc aac tcc atc atc tcc ttg      437
 Ile Leu Arg Phe Gly Thr Arg Ser Leu Cys Asn Ser Ile Ile Ser Leu
 120                 125                 130                 135

 aac act aca att agc tgt tct gaa gcc cag aaa att cca tgg aca ccc      485
 Asn Thr Thr Ile Ser Cys Ser Glu Ala Gln Lys Ile Pro Trp Thr Pro
                 140                 145                 150

 cct gga act gct ctg cag ttt tac tcc aac cta cac aat gct gaa acc      533
 Pro Gly Thr Ala Leu Gln Phe Tyr Ser Asn Leu His Asn Ala Glu Thr
             155                 160                 165

 tct tct tgg gtg aat ttg gta ttg tgg tgt gtg gtc ttg gtg ctc cag      581
 Ser Ser Trp Val Asn Leu Val Leu Trp Cys Val Val Leu Val Leu Gln
         170                 175                 180

 gtc gtg cag tgg aag tct gaa gcc acc cca tac cgg cct ctg gag agg      629
 Val Val Gln Trp Lys Ser Glu Ala Thr Pro Tyr Arg Pro Leu Glu Arg
     185                 190                 195

 ggt gac cct gag tgg agc tct gag aca gat gct ctc gtt ggg tca cgc      677
 Gly Asp Pro Glu Trp Ser Ser Glu Thr Asp Ala Leu Val Gly Ser Arg
 200                 205                 210                 215

 ctt tcc cat tcc tga agaataagcg gagtgcttcc tgcagccgaa gactccatgc      732
 Leu Ser His Ser 


 ccaagtgcct gtaatccccc ccctcaaggc cctgtttatg ttgggagtct tagttttcct    792

 ttcgttgggg ggtggggggg aaacataatg acaggccccc ctccacctct tcctgcagct    852

 gtttttgtac caaaatatta tatt                                           876




      <210> 218
      <211> 3345
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (36)..(2873)

      <400> 218
 ggcgccgccg cggagcctcc cgggccgccg cgatc   atg tcg gac cag gcg ccc      53
                                          Met Ser Asp Gln Ala Pro
                                            1               5

 aaa gtt cct gag gag atg ttc agg gag gtc aag tat tac gcg gtg ggc      101
 Lys Val Pro Glu Glu Met Phe Arg Glu Val Lys Tyr Tyr Ala Val Gly
              10                  15                  20

 gac atc gac ccg cag gtt att cag ctt ctc aag gct gga aaa gcg aag      149
 Asp Ile Asp Pro Gln Val Ile Gln Leu Leu Lys Ala Gly Lys Ala Lys
          25                  30                  35

 gaa gtt tcc tac aat gca cta gcc tca cac ata atc tca gag gat ggg      197
 Glu Val Ser Tyr Asn Ala Leu Ala Ser His Ile Ile Ser Glu Asp Gly
      40                  45                  50

 gac aat cca gag gtg gga gaa gct cgg gaa gtc ttt gac tta cct gtt      245
 Asp Asn Pro Glu Val Gly Glu Ala Arg Glu Val Phe Asp Leu Pro Val
  55                  60                  65                  70

 gta aag cct tct tgg gtg att ctg tcc gtt cag tgt gga act ctt ctg      293
 Val Lys Pro Ser Trp Val Ile Leu Ser Val Gln Cys Gly Thr Leu Leu
                  75                  80                  85

 cca gta aat ggt ttt tct cca gaa tca tgt cag att ttt ttt gga atc      341
 Pro Val Asn Gly Phe Ser Pro Glu Ser Cys Gln Ile Phe Phe Gly Ile
              90                  95                 100

 act gcc tgc ctt tct cag gtg tca tct gaa gac aga agt gcc ctg tgg      389
 Thr Ala Cys Leu Ser Gln Val Ser Ser Glu Asp Arg Ser Ala Leu Trp
         105                 110                 115

 gct ttg gtt acg ttc tat ggg gga gat tgc cag cta acc ctc aat aag      437
 Ala Leu Val Thr Phe Tyr Gly Gly Asp Cys Gln Leu Thr Leu Asn Lys
     120                 125                 130

 aaa tgc acg cat ttg att gtt cca gag cca aag ggg gag aaa tac gaa      485
 Lys Cys Thr His Leu Ile Val Pro Glu Pro Lys Gly Glu Lys Tyr Glu
 135                 140                 145                 150

 tgt gct tta aag cga gca agt att aaa att gtg act cct gac tgg gtt      533
 Cys Ala Leu Lys Arg Ala Ser Ile Lys Ile Val Thr Pro Asp Trp Val
                 155                 160                 165

 ctg gat tgc gta tca gag aaa acc aaa aag gac gaa gca ttt tat cat      581
 Leu Asp Cys Val Ser Glu Lys Thr Lys Lys Asp Glu Ala Phe Tyr His
             170                 175                 180

 cct cgt ctg att att tat gaa gag gaa gaa gag gaa gag gaa gag gag      629
 Pro Arg Leu Ile Ile Tyr Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
         185                 190                 195

 gag gaa gta gaa aat gag gaa caa gat tct cag aat gag ggt agt aca      677
 Glu Glu Val Glu Asn Glu Glu Gln Asp Ser Gln Asn Glu Gly Ser Thr
     200                 205                 210

 gat gag aag tca agc cct gcc agc tct caa gaa ggg tct cct tca ggt      725
 Asp Glu Lys Ser Ser Pro Ala Ser Ser Gln Glu Gly Ser Pro Ser Gly
 215                 220                 225                 230

 gac cag cag ttt tca cct aaa tcc aac act gaa aaa tct aaa ggg gaa      773
 Asp Gln Gln Phe Ser Pro Lys Ser Asn Thr Glu Lys Ser Lys Gly Glu
                 235                 240                 245

 tta atg ttt gat gat tct tca gat tca tca ccg gaa aaa cag gag aga      821
 Leu Met Phe Asp Asp Ser Ser Asp Ser Ser Pro Glu Lys Gln Glu Arg
             250                 255                 260

 aat tta aac tgg acc ccg gcc gaa gtc cca cag tta gct gca gca aaa      869
 Asn Leu Asn Trp Thr Pro Ala Glu Val Pro Gln Leu Ala Ala Ala Lys
         265                 270                 275

 cgc agg ctg cct cag gga aag gag cct ggg ttg att aac ttg tgt gcc      917
 Arg Arg Leu Pro Gln Gly Lys Glu Pro Gly Leu Ile Asn Leu Cys Ala
     280                 285                 290

 aat gtc cca ccc gtc cca ggt aac att ttg ccc cct gag gtc cgg ggt      965
 Asn Val Pro Pro Val Pro Gly Asn Ile Leu Pro Pro Glu Val Arg Gly
 295                 300                 305                 310

 aat tta atg gct gct gga caa aac ctc caa agt tct gaa aga tca gaa     1013
 Asn Leu Met Ala Ala Gly Gln Asn Leu Gln Ser Ser Glu Arg Ser Glu
                 315                 320                 325

 atg ata gct acc tgg agt cca gct gta cgg aca ctg agg aat att act     1061
 Met Ile Ala Thr Trp Ser Pro Ala Val Arg Thr Leu Arg Asn Ile Thr
             330                 335                 340

 aat aat gct gac att cag cag atg aac cgg cca tca aat gta gca cat     1109
 Asn Asn Ala Asp Ile Gln Gln Met Asn Arg Pro Ser Asn Val Ala His
         345                 350                 355

 atc tta cag act ctt tca gca cct acg aaa aat tta gaa cag cag gtg     1157
 Ile Leu Gln Thr Leu Ser Ala Pro Thr Lys Asn Leu Glu Gln Gln Val
     360                 365                 370

 aat cac agc cag cag gga cat aca aat gcc aat gca gtg ctg ttt agc     1205
 Asn His Ser Gln Gln Gly His Thr Asn Ala Asn Ala Val Leu Phe Ser
 375                 380                 385                 390

 caa gtg aaa gtg act cca gag aca cac atg cta cag cag cag cag cag     1253
 Gln Val Lys Val Thr Pro Glu Thr His Met Leu Gln Gln Gln Gln Gln
                 395                 400                 405

 gcc cag cag cag cag cag cag cac ccg gtt tta cac ctt cag ccc cag     1301
 Ala Gln Gln Gln Gln Gln Gln His Pro Val Leu His Leu Gln Pro Gln
             410                 415                 420

 cag ata atg cag ctc cag cag cag cag cag cag cag atc tct cag caa     1349
 Gln Ile Met Gln Leu Gln Gln Gln Gln Gln Gln Gln Ile Ser Gln Gln
         425                 430                 435

 cct tac ccc cag cag ccg ccg cat cca ttt tca cag cag cag cag cag     1397
 Pro Tyr Pro Gln Gln Pro Pro His Pro Phe Ser Gln Gln Gln Gln Gln
     440                 445                 450

 caa cag cag cca cca cca tcg cct cag cag cat cag ctt ttt gga cat     1445
 Gln Gln Gln Pro Pro Pro Ser Pro Gln Gln His Gln Leu Phe Gly His
 455                 460                 465                 470

 gat cca gca gtg gag att cca gaa gaa ggc ttc tta ttg gga tgt gtg     1493
 Asp Pro Ala Val Glu Ile Pro Glu Glu Gly Phe Leu Leu Gly Cys Val
                 475                 480                 485

 ttt gca att gcg gat tat cca gag cag atg tct gat aag caa ctg ctg     1541
 Phe Ala Ile Ala Asp Tyr Pro Glu Gln Met Ser Asp Lys Gln Leu Leu
             490                 495                 500

 gcc acc tgg aaa agg ata atc cag gca cat ggc ggc act gtt gac ccc     1589
 Ala Thr Trp Lys Arg Ile Ile Gln Ala His Gly Gly Thr Val Asp Pro
         505                 510                 515

 acc ttc acg agt cga tgc acg cac ctt ctc tgt gag agt caa gtc agc     1637
 Thr Phe Thr Ser Arg Cys Thr His Leu Leu Cys Glu Ser Gln Val Ser
     520                 525                 530

 agc gcg tat gca cag gca ata aga gaa aga aag aga tgt gtt act gca     1685
 Ser Ala Tyr Ala Gln Ala Ile Arg Glu Arg Lys Arg Cys Val Thr Ala
 535                 540                 545                 550

 cac tgg tta aac aca gtc tta aag aag aag aaa atg gta ccg ccg cac     1733
 His Trp Leu Asn Thr Val Leu Lys Lys Lys Lys Met Val Pro Pro His
                 555                 560                 565

 cga gcc ctt cac ttc cca gtg gcc ttc cca cca gga gga aag cca tgt     1781
 Arg Ala Leu His Phe Pro Val Ala Phe Pro Pro Gly Gly Lys Pro Cys
             570                 575                 580

 tca cag cat att att tct gtg act gga ttt gtt gat agt gac aga gat     1829
 Ser Gln His Ile Ile Ser Val Thr Gly Phe Val Asp Ser Asp Arg Asp
         585                 590                 595

 gac cta aaa tta atg gct tat ttg gca ggt gcc aaa tat acg ggt tat     1877
 Asp Leu Lys Leu Met Ala Tyr Leu Ala Gly Ala Lys Tyr Thr Gly Tyr
     600                 605                 610

 cta tgc cgc agc aac aca gtc ctc atc tgt aaa gaa cca act ggt tta     1925
 Leu Cys Arg Ser Asn Thr Val Leu Ile Cys Lys Glu Pro Thr Gly Leu
 615                 620                 625                 630

 aag tat gaa aaa gcc aaa gag tgg agg ata ccc tgt gtc aac gcc cag     1973
 Lys Tyr Glu Lys Ala Lys Glu Trp Arg Ile Pro Cys Val Asn Ala Gln
                 635                 640                 645

 tgg ctt ggc gac att ctt ctg gga aac ttt gag gca ctg agg cag att     2021
 Trp Leu Gly Asp Ile Leu Leu Gly Asn Phe Glu Ala Leu Arg Gln Ile
             650                 655                 660

 cag tat agt cgc tac acg gca ttc agt ctg cag gat cca ttt gcc cct     2069
 Gln Tyr Ser Arg Tyr Thr Ala Phe Ser Leu Gln Asp Pro Phe Ala Pro
         665                 670                 675

 acc cag cat tta gtt tta aat ctt tta gat gct tgg aga gtt ccc tta     2117
 Thr Gln His Leu Val Leu Asn Leu Leu Asp Ala Trp Arg Val Pro Leu
     680                 685                 690

 aaa gtg tct gca gag ttg ttg atg agt ata aga cta cct ccc aaa ctg     2165
 Lys Val Ser Ala Glu Leu Leu Met Ser Ile Arg Leu Pro Pro Lys Leu
 695                 700                 705                 710

 aaa cag aat gaa gta gct aat gtc cag cct tct tcc aaa aga gcc aga     2213
 Lys Gln Asn Glu Val Ala Asn Val Gln Pro Ser Ser Lys Arg Ala Arg
                 715                 720                 725

 att gaa gac gta cca cct ccc act aaa aag cta act cca gaa ttg acc     2261
 Ile Glu Asp Val Pro Pro Pro Thr Lys Lys Leu Thr Pro Glu Leu Thr
             730                 735                 740

 cct ttt gtg ctt ttc act gga ttc gag cct gtc cag gtt caa cag tat     2309
 Pro Phe Val Leu Phe Thr Gly Phe Glu Pro Val Gln Val Gln Gln Tyr
         745                 750                 755

 att aag aag ctc tac att ctt ggt gga gag gtt gcg gag tct gca cag     2357
 Ile Lys Lys Leu Tyr Ile Leu Gly Gly Glu Val Ala Glu Ser Ala Gln
     760                 765                 770

 aag tgc aca cac ctc att gcc agc aaa gtg act cgc acc gtg aag ttc     2405
 Lys Cys Thr His Leu Ile Ala Ser Lys Val Thr Arg Thr Val Lys Phe
 775                 780                 785                 790

 ctg acg gcg att tct gtc gtg aag cac ata gtg acg cca gag tgg ctg     2453
 Leu Thr Ala Ile Ser Val Val Lys His Ile Val Thr Pro Glu Trp Leu
                 795                 800                 805

 gaa gaa tgc ttc agg tgt cag aag ttc att gat gag cag aac tac att     2501
 Glu Glu Cys Phe Arg Cys Gln Lys Phe Ile Asp Glu Gln Asn Tyr Ile
             810                 815                 820

 ctc cga gat gct gag gca gaa gta ctt ttc tct ttc agc ttg gaa gaa     2549
 Leu Arg Asp Ala Glu Ala Glu Val Leu Phe Ser Phe Ser Leu Glu Glu
         825                 830                 835

 tcc tta aaa cgg gca cac gtt tct cca ctc ttt aag gca aaa tat ttt     2597
 Ser Leu Lys Arg Ala His Val Ser Pro Leu Phe Lys Ala Lys Tyr Phe
     840                 845                 850

 tac atc aca cct gga atc tgc cca agt ctt tcc act atg aag gca atc     2645
 Tyr Ile Thr Pro Gly Ile Cys Pro Ser Leu Ser Thr Met Lys Ala Ile
 855                 860                 865                 870

 gta gag tgt gca gga gga aag gtg tta tcc aag cag cca tct ttc cgg     2693
 Val Glu Cys Ala Gly Gly Lys Val Leu Ser Lys Gln Pro Ser Phe Arg
                 875                 880                 885

 aag ctc atg gag cac aag cag aac tcg agt ttg tcg gaa ata att tta     2741
 Lys Leu Met Glu His Lys Gln Asn Ser Ser Leu Ser Glu Ile Ile Leu
             890                 895                 900

 ata tcc tgt gaa aat gac ctt cat tta tgc cga gaa tat ttt gcc aga     2789
 Ile Ser Cys Glu Asn Asp Leu His Leu Cys Arg Glu Tyr Phe Ala Arg
         905                 910                 915

 ggc ata gat gtt cac aat gca gag ttc gtt ctg act gga gtg ctc act     2837
 Gly Ile Asp Val His Asn Ala Glu Phe Val Leu Thr Gly Val Leu Thr
     920                 925                 930

 caa acg ctg gac tat gaa tca tat aag ttt aac tga tggc gtctaggctg     2887
 Gln Thr Leu Asp Tyr Glu Ser Tyr Lys Phe Asn 
 935                 940                 945

 ccgtgcatgt cgactcctgc ggtgcggggc tggctgtctg gctggcgagg agctgctgcg   2947

 cttccttcac atgctcttgt tttccagctg ctttcctggg ggatcagact gtgaagcagg   3007

 aagacagata taataaatat actgcatctt tttaagatgt gcaattttat tctgaggaaa   3067

 cataaattat gttttgtatt atatgacttt aagagcccac attaggtttt atgattcatt   3127

 tgccaggttt ttaaatgttt tcacaaaact gttacgggac ttcaactaga aataaaatgg   3187

 tgtaaataaa gaccttgcta tctctaaatt atggatgtta aagatttgaa atgttttgta   3247

 ctttgattat ttttatttct tatactctgt tttcttttat attgatatct tgcccacatt   3307

 ttaaataaat gtacttttga acttaaaaaa aaaaaaaa                           3345




      <210> 219
      <211> 3508
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (36)..(479)

      <400> 219
 ggcgccgccg cggagcctcc cgggccgccg cgatc   atg tcg gac cag gcg ccc      53
                                          Met Ser Asp Gln Ala Pro
                                            1               5

 aaa gtt cct gag gag atg ttc agg gag gtc aag tat tac gcg gtg ggc      101
 Lys Val Pro Glu Glu Met Phe Arg Glu Val Lys Tyr Tyr Ala Val Gly
              10                  15                  20

 gac atc gac ccg cag gtt att cag ctt ctc aag gct gga aaa gcg aag      149
 Asp Ile Asp Pro Gln Val Ile Gln Leu Leu Lys Ala Gly Lys Ala Lys
          25                  30                  35

 gaa gtt tcc tac aat gca cta gcc tca cac ata atc tca gag gat ggg      197
 Glu Val Ser Tyr Asn Ala Leu Ala Ser His Ile Ile Ser Glu Asp Gly
      40                  45                  50

 gac aat cca gag gtg gga gaa gct cgg gaa gtc ttt gac tta cct gtt      245
 Asp Asn Pro Glu Val Gly Glu Ala Arg Glu Val Phe Asp Leu Pro Val
  55                  60                  65                  70

 gta aag cct tct tgg gtg att ctg tcc gtt cag tgt gga act ctt ctg      293
 Val Lys Pro Ser Trp Val Ile Leu Ser Val Gln Cys Gly Thr Leu Leu
                  75                  80                  85

 cca gta aat ggt ttt tct cca gaa tca tgt cag att ttt ttt gga atc      341
 Pro Val Asn Gly Phe Ser Pro Glu Ser Cys Gln Ile Phe Phe Gly Ile
              90                  95                 100

 act gcc tgc ctt tct cag ggt gtt gat aca agc tgg agc tct ttg ttg      389
 Thr Ala Cys Leu Ser Gln Gly Val Asp Thr Ser Trp Ser Ser Leu Leu
         105                 110                 115

 gag tct tcc aga gct ctc cca agg aga ggt agg gaa ggg agc ttg tcc      437
 Glu Ser Ser Arg Ala Leu Pro Arg Arg Gly Arg Glu Gly Ser Leu Ser
     120                 125                 130

 agc aga agt tgg gaa gca cag aga tca tct gcc ttc ttc tga cccggta      486
 Ser Arg Ser Trp Glu Ala Gln Arg Ser Ser Ala Phe Phe 
 135                 140                 145

 ttgatgcagg ctgaggcctc tgttgtaatg tgctgggtgt catctgaaga cagaagtgcc    546

 ctgtgggctt tggttacgtt ctatggggga gattgccagc taaccctcaa taagaaatgc    606

 acgcatttga ttgttccaga gccaaagggg gagaaatacg aatgtgcttt aaagcgagca    666

 agtattaaaa ttgtgactcc tgactgggtt ctggattgcg tatcagagaa aaccaaaaag    726

 gacgaagcat tttatcatcc tcgtctgatt atttatgaag aggaagaaga ggaagaggaa    786

 gaggaggagg aagtagaaaa tgaggaacaa gattctcaga atgagggtag tacagatgag    846

 aagtcaagcc ctgccagctc tcaagaaggg tctccttcag gtgaccagca gttttcacct    906

 aaatccaaca ctgaaaaatc taaaggggaa ttaatgtttg atgattcttc agattcatca    966

 ccggaaaaac aggagagaaa tttaaactgg accccggccg aagtcccaca gttagctgca   1026

 gcaaaacgca ggctgcctca gggaaaggag cctgggttga ttaacttgtg tgccaatgtc   1086

 ccacccgtcc caggtaacat tttgccccct gaggtccggg gtaatttaat ggctgctgga   1146

 caaaacctcc aaagttctga aagatcagaa atgatagcta cctggagtcc agctgtacgg   1206

 acactgagga atattactaa taatgctgac attcagcaga tgaaccggcc atcaaatgta   1266

 gcacatatct tacagactct ttcagcacct acgaaaaatt tagaacagca ggtgaatcac   1326

 agccagcagg gacatacaaa tgccaatgca gtgctgttta gccaagtgaa agtgactcca   1386

 gagacacaca tgctacagca gcagcagcag gcccagcagc agcagcagca gcacccggtt   1446

 ttacaccttc agccccagca gataatgcag ctccagcagc agcagcagca gcagatctct   1506

 cagcaacctt acccccagca gccgccgcat ccattttcac agcagcagca gcagcaacag   1566

 cagccaccac catcgcctca gcagcatcag ctttttggac atgatccagc agtggagatt   1626

 ccagaagaag gcttcttatt gggatgtgtg tttgcaattg cggattatcc agagcagatg   1686

 tctgataagc aactgctggc cacctggaaa aggataatcc aggcacatgg cggcactgtt   1746

 gaccccacct tcacgagtcg atgcacgcac cttctctgtg agagtcaagt cagcagcgcg   1806

 tatgcacagg caataagaga aagaaagaga tgtgttactg cacactggtt aaacacagtc   1866

 ttaaagaaga agaaaatggt accgccgcac cgagcccttc acttcccagt ggccttccca   1926

 ccaggaggaa agccatgttc acagcatatt atttctgtga ctggatttgt tgatagtgac   1986

 agagatgacc taaaattaat ggcttatttg gcaggtgcca aatatacggg ttatctatgc   2046

 cgcagcaaca cagtcctcat ctgtaaagaa ccaactggtt taaagtatga aaaagccaaa   2106

 gagtggagga taccctgtgt caacgcccag tggcttggcg acattcttct gggaaacttt   2166

 gaggcactga ggcagattca gtatagtcgc tacacggcat tcagtctgca ggatccattt   2226

 gcccctaccc agcatttagt tttaaatctt ttagatgctt ggagagttcc cttaaaagtg   2286

 tctgcagagt tgttgatgag tataagacta cctcccaaac tgaaacagaa tgaagtagct   2346

 aatgtccagc cttcttccaa aagagccaga attgaagacg taccacctcc cactaaaaag   2406

 ctaactccag aattgacccc ttttgtgctt ttcactggat tcgagcctgt ccaggttcaa   2466

 cagtatatta agaagctcta cattcttggt ggagaggttg cggagtctgc acagaagtgc   2526

 acacacctca ttgccagcaa agtgactcgc accgtgaagt tcctgacggc gatttctgtc   2586

 gtgaagcaca tagtgacgcc agagtggctg gaagaatgct tcaggtgtca gaagttcatt   2646

 gatgagcaga actacattct ccgagatgct gaggcagaag tacttttctc tttcagcttg   2706

 gaagaatcct taaaacgggc acacgtttct ccactcttta aggcaaaata tttttacatc   2766

 acacctggaa tctgcccaag tctttccact atgaaggcaa tcgtagagtg tgcaggagga   2826

 aaggtgttat ccaagcagcc atctttccgg aagctcatgg agcacaagca gaactcgagt   2886

 ttgtcggaaa taattttaat atcctgtgaa aatgaccttc atttatgccg agaatatttt   2946

 gccagaggca tagatgttca caatgcagag ttcgttctga ctggagtgct cactcaaacg   3006

 ctggactatg aatcatataa gtttaactga tggcgtctag gctgccgtgc atgtcgactc   3066

 ctgcggtgcg gggctggctg tctggctggc gaggagctgc tgcgcttcct tcacatgctc   3126

 ttgttttcca gctgctttcc tgggggatca gactgtgaag caggaagaca gatataataa   3186

 atatactgca tctttttaag atgtgcaatt ttattctgag gaaacataaa ttatgttttg   3246

 tattatatga ctttaagagc ccacattagg ttttatgatt catttgccag gtttttaaat   3306

 gttttcacaa aactgttacg ggacttcaac tagaaataaa atggtgtaaa taaagacctt   3366

 gctatctcta aattatggat gttaaagatt tgaaatgttt tgtactttga ttatttttat   3426

 ttcttatact ctgttttctt ttatattgat atcttgccca cattttaaat aaatgtactt   3486

 ttgaacttaa aaaaaaaaaa aa                                            3508




      <210> 220
      <211> 1148
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (102)..(959)

      <400> 220
 actcgcgtcc ctgcgccgtg cctgcctcgc gctccctgtt acggcgttcg tccccgggcc     60

 tggcgcccgc gtccggcccg gctccgcggc ggcctggtcc g    atg gct cct cag     113
                                                  Met Ala Pro Gln
                                                    1

 cgg agg gcc gca acc aag gcg ccc gag ggc aac gga gcg gcc gag cgc      161
 Arg Arg Ala Ala Thr Lys Ala Pro Glu Gly Asn Gly Ala Ala Glu Arg
   5                  10                  15                  20

 cgg aac cgg agc agc acc aag aag gac cga gcc ccg cgg gag gtg cag      209
 Arg Asn Arg Ser Ser Thr Lys Lys Asp Arg Ala Pro Arg Glu Val Gln
                  25                  30                  35

 agg ctg tgg cag agg ccg tgg cta agg acc gcg ggc ctg ggg gct ggc      257
 Arg Leu Trp Gln Arg Pro Trp Leu Arg Thr Ala Gly Leu Gly Ala Gly
              40                  45                  50

 ttt gtg ctc acc gca ctc ctg ctc tgg agc agc ttg ggg gcc gac gac      305
 Phe Val Leu Thr Ala Leu Leu Leu Trp Ser Ser Leu Gly Ala Asp Asp
          55                  60                  65

 ggg gtc gca gag gtc ctg gcc cgc cgt ggc gag gtc gtg gca ggg aga      353
 Gly Val Ala Glu Val Leu Ala Arg Arg Gly Glu Val Val Ala Gly Arg
      70                  75                  80

 ttc atc gag gtg ccc tgc tct gag gac tac gac agt cac cgc agg ttc      401
 Phe Ile Glu Val Pro Cys Ser Glu Asp Tyr Asp Ser His Arg Arg Phe
  85                  90                  95                 100

 gaa ggc tgc act ccc cga aag tgc ggc aga ggt gtc acc gat gtc gtc      449
 Glu Gly Cys Thr Pro Arg Lys Cys Gly Arg Gly Val Thr Asp Val Val
                 105                 110                 115

 atc acc agg gag gaa gcg gag cgg att cgc agc gta gct gaa aag ggg      497
 Ile Thr Arg Glu Glu Ala Glu Arg Ile Arg Ser Val Ala Glu Lys Gly
             120                 125                 130

 ctc tcc ctg gga gga tct gac gga ggg gca tcc att ctg gac ttg cac      545
 Leu Ser Leu Gly Gly Ser Asp Gly Gly Ala Ser Ile Leu Asp Leu His
         135                 140                 145

 tca ggg gcc ctg tct gtc ggg aag cac ttt gtg aac ctg tac aga tac      593
 Ser Gly Ala Leu Ser Val Gly Lys His Phe Val Asn Leu Tyr Arg Tyr
     150                 155                 160

 ttc ggg gat aaa ata cag aac atc ttc tca gag gag gac ttc cgg tta      641
 Phe Gly Asp Lys Ile Gln Asn Ile Phe Ser Glu Glu Asp Phe Arg Leu
 165                 170                 175                 180

 tac cgc acg gaa gcg cgg acg gcg cac gac gag tac tgg cat gcg cac      689
 Tyr Arg Thr Glu Ala Arg Thr Ala His Asp Glu Tyr Trp His Ala His
                 185                 190                 195

 gtg gac aag gtg acc tac ggc tcc ttc gac tac acc tcg ctg ctg tac      737
 Val Asp Lys Val Thr Tyr Gly Ser Phe Asp Tyr Thr Ser Leu Leu Tyr
             200                 205                 210

 ctc tcc aac tac ctg gag gac ttc ggc gga ggg cgg ttc atg ttc atg      785
 Leu Ser Asn Tyr Leu Glu Asp Phe Gly Gly Gly Arg Phe Met Phe Met
         215                 220                 225

 gag gag ggt gcc aac aag acg gtg gag ccg aga gct ggt cgc gtc tcc      833
 Glu Glu Gly Ala Asn Lys Thr Val Glu Pro Arg Ala Gly Arg Val Ser
     230                 235                 240

 ttc ttc acc tcg ggg tcc gag aac cta cac cgc gtg gag aag gtc cac      881
 Phe Phe Thr Ser Gly Ser Glu Asn Leu His Arg Val Glu Lys Val His
 245                 250                 255                 260

 tgg ggc acc cgt tac gcc att acc atc gcc ttc agc tgc aac ccc gac      929
 Trp Gly Thr Arg Tyr Ala Ile Thr Ile Ala Phe Ser Cys Asn Pro Asp
                 265                 270                 275

 cat ggc atc gag gac cca gcg ttc ccg tag c cagcagccgg gccaaggtaa      980
 His Gly Ile Glu Asp Pro Ala Phe Pro 
             280                 285

 cttcaggagg gcccgtgtgg aggcagccgc gccagtcgtg cacccacccc cacgtccacc   1040

 cgctcctgtt gcacagagtg ccttaggaat tctctgattt tgatttgctg acgtgttaat   1100

 cttttcatct gtgagtaaat gaagggaacc agcaaaaaaa aaaaaaaa                1148




      <210> 221
      <211> 1502
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (452)..(1354)

      <400> 221
 aaccacctgc ccgtttgtgg atggttgctc ttcggatact tgatttttta tacataacat     60

 tttgaggata tcagaatcag gctttcaaca tcttgaaaac cttgcttgtt tgtatttagg    120

 aagtaataat ttaacaaaag taccatcaaa tgcctttgaa gtacttaaaa gtcttagaag    180

 actttctttg tctcataatc ctattgaagc aatacagccc tttgcattta aaggacttgc    240

 caatctggaa tacctcctcc tgaaaaattc aagaattagg aatgttacta gggatgggtt    300

 tagtggaatt aataatctta aacatttgat cttaagtcat aatgatttag agaatttaaa    360

 ttctgacaca ttcagtttgt taaagaattt aatttacctt aagttagata gaaacagaat    420

 aattagcatt gataatgata catttgaaaa t   atg gga gca tct ttg aag atc     472
                                      Met Gly Ala Ser Leu Lys Ile
                                        1               5

 ctt aat ctg tca ttt aat aat ctt aca gcc ttg cat cca agg gtc ctt      520
 Leu Asn Leu Ser Phe Asn Asn Leu Thr Ala Leu His Pro Arg Val Leu
          10                  15                  20

 aag ccg ttg tct tca ttg att cat ctt cag gca aat tct aat cct tgg      568
 Lys Pro Leu Ser Ser Leu Ile His Leu Gln Ala Asn Ser Asn Pro Trp
      25                  30                  35

 gaa tgt aac tgc aaa ctt ttg ggc ctt cga gac tgg cta gca tct tca      616
 Glu Cys Asn Cys Lys Leu Leu Gly Leu Arg Asp Trp Leu Ala Ser Ser
  40                  45                  50                  55

 gcc att act cta aac atc tat tgt cag aat ccc cca tcc atg cgt ggc      664
 Ala Ile Thr Leu Asn Ile Tyr Cys Gln Asn Pro Pro Ser Met Arg Gly
                  60                  65                  70

 aga gca tta cgt tat att aac att aca aat tgt gtt aca tct tca ata      712
 Arg Ala Leu Arg Tyr Ile Asn Ile Thr Asn Cys Val Thr Ser Ser Ile
              75                  80                  85

 aat gta tcc aga gct tgg gct gtt gta aaa tct cct cat att cat cac      760
 Asn Val Ser Arg Ala Trp Ala Val Val Lys Ser Pro His Ile His His
          90                  95                 100

 aag act act gcg cta atg atg gcc tgg cat aaa gta acc aca aat ggc      808
 Lys Thr Thr Ala Leu Met Met Ala Trp His Lys Val Thr Thr Asn Gly
     105                 110                 115

 agt cct ctg gaa aat act gag act gag aac att act ttc tgg gaa cga      856
 Ser Pro Leu Glu Asn Thr Glu Thr Glu Asn Ile Thr Phe Trp Glu Arg
 120                 125                 130                 135

 att cct act tca cct gct ggt aga ttt ttt caa gag aat gcc ttt ggt      904
 Ile Pro Thr Ser Pro Ala Gly Arg Phe Phe Gln Glu Asn Ala Phe Gly
                 140                 145                 150

 aat cca tta gag act aca gca gtg tta cct gtg caa ata caa ctt act      952
 Asn Pro Leu Glu Thr Thr Ala Val Leu Pro Val Gln Ile Gln Leu Thr
             155                 160                 165

 act tct gtt acc ttg aac ttg gaa aaa aac agt gct cta ccg aat gat     1000
 Thr Ser Val Thr Leu Asn Leu Glu Lys Asn Ser Ala Leu Pro Asn Asp
         170                 175                 180

 gct gct tca atg tca ggg aaa aca tct cta att tgt aca caa gaa gtt     1048
 Ala Ala Ser Met Ser Gly Lys Thr Ser Leu Ile Cys Thr Gln Glu Val
     185                 190                 195

 gag aag ttg aat gag gct ttt gac att ttg cta gct ttt ttc atc tta     1096
 Glu Lys Leu Asn Glu Ala Phe Asp Ile Leu Leu Ala Phe Phe Ile Leu
 200                 205                 210                 215

 gct tgt gtt tta atc att ttt ttg atc tac aaa gtt gtt cag ttt aaa     1144
 Ala Cys Val Leu Ile Ile Phe Leu Ile Tyr Lys Val Val Gln Phe Lys
                 220                 225                 230

 caa aaa cta aag gca tca gaa aac tca agg gaa aat aga ctt gaa tac     1192
 Gln Lys Leu Lys Ala Ser Glu Asn Ser Arg Glu Asn Arg Leu Glu Tyr
             235                 240                 245

 tac agc ttt tat cag tca gca agg tat aat gta act gcc tca att tgt     1240
 Tyr Ser Phe Tyr Gln Ser Ala Arg Tyr Asn Val Thr Ala Ser Ile Cys
         250                 255                 260

 aac act tcc cca aat tct cta gaa agt cct ggc ttg gag cag att cga     1288
 Asn Thr Ser Pro Asn Ser Leu Glu Ser Pro Gly Leu Glu Gln Ile Arg
     265                 270                 275

 ctt cat aaa caa att gtt cct gaa aat gag gca cag gtc att ctt ttt     1336
 Leu His Lys Gln Ile Val Pro Glu Asn Glu Ala Gln Val Ile Leu Phe
 280                 285                 290                 295

 gaa cat tct gct tta taa ctcaac taaatattgt ctataagaaa cttcagtgcc     1390
 Glu His Ser Ala Leu 
                 300

 atggacatga tttaaactga aacctcctta tataattata tactttagtt ggaaatataa   1450

 tgaattatat gaggttagca ttattaaaat atgtttttaa taaaaaaaaa aa           1502




      <210> 222
      <211> 936
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(724)

      <400> 222
 ggctgtccga ctcaacatat cctatcctcc tcagaacttg acc  atg act gtc ttc      55
                                                  Met Thr Val Phe
                                                    1

 caa gga gat ggc aca gca tcc aca acc ttg agg aat ggc tcg gcc ctt      103
 Gln Gly Asp Gly Thr Ala Ser Thr Thr Leu Arg Asn Gly Ser Ala Leu
   5                  10                  15                  20

 tca gtc ctg gag ggc cag tcc ctg cac ctt gtc tgt gct gtc gac agc      151
 Ser Val Leu Glu Gly Gln Ser Leu His Leu Val Cys Ala Val Asp Ser
                  25                  30                  35

 aat ccc cct gcc agg ctg agc tgg acc tgg ggg agc ctg acc ctg agc      199
 Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp Gly Ser Leu Thr Leu Ser
              40                  45                  50

 ccc tca cag tcc tcg aac ctt ggg gtg ctg gag ctg cct cga gtg cat      247
 Pro Ser Gln Ser Ser Asn Leu Gly Val Leu Glu Leu Pro Arg Val His
          55                  60                  65

 gtg aag gat gaa ggg gaa ttc acc tgc cga gct cag aac cct cta ggc      295
 Val Lys Asp Glu Gly Glu Phe Thr Cys Arg Ala Gln Asn Pro Leu Gly
      70                  75                  80

 tcc cag cac att tcc ctg agc ctc tcc ctg caa aac gag tac aca ggc      343
 Ser Gln His Ile Ser Leu Ser Leu Ser Leu Gln Asn Glu Tyr Thr Gly
  85                  90                  95                 100

 aaa atg agg cct ata tca gga gtg acg cta ggg gca ttc ggg gga gct      391
 Lys Met Arg Pro Ile Ser Gly Val Thr Leu Gly Ala Phe Gly Gly Ala
                 105                 110                 115

 gga gcc aca gcc ctg gtc ttc ctg tac ttc tgc atc atc ttc gtt gta      439
 Gly Ala Thr Ala Leu Val Phe Leu Tyr Phe Cys Ile Ile Phe Val Val
             120                 125                 130

 gtg agg tcc tgc agg aag aaa tcg gca agg cca gca gtg ggc gtg ggg      487
 Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Val Gly Val Gly
         135                 140                 145

 gat aca ggc atg gag gac gca aac gct gtc agg ggc tca gcc tct cag      535
 Asp Thr Gly Met Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser Gln
     150                 155                 160

 gga ccc ctg att gaa tcc ccg gca gat gac agc ccc cca cac cat gct      583
 Gly Pro Leu Ile Glu Ser Pro Ala Asp Asp Ser Pro Pro His His Ala
 165                 170                 175                 180

 ccg cca gcc ctg gcc acc ccc tcc cca gag gaa gga gag atc cag tat      631
 Pro Pro Ala Leu Ala Thr Pro Ser Pro Glu Glu Gly Glu Ile Gln Tyr
                 185                 190                 195

 gca tcc ctc agc ttc cac aaa gcg agg cct cag tac cca cag gaa cag      679
 Ala Ser Leu Ser Phe His Lys Ala Arg Pro Gln Tyr Pro Gln Glu Gln
             200                 205                 210

 gag gcc atc ggc tat gag tac tcc gag atc aac atc ccc aag tga gaa      727
 Glu Ala Ile Gly Tyr Glu Tyr Ser Glu Ile Asn Ile Pro Lys 
         215                 220                 225

 actgcagaga ctcaggcctg tttgagggct cacgacccct gcagcaaaga agcccgagac    787

 tgattccttt agaattaaca gccctccatg ctgtgcaaca ggacatcaaa acttattcct    847

 cttgtcaaac tgaaaatgcg tgcctaatga ccaaactctc cctttctcca tccaatcggg    907

 ccacactccc cgcccccggg ctttgggac                                      936




      <210> 223
      <211> 896
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (284)..(841)

      <220>
      <221> misc_feature
      <222> (1)...(896)
      <223> n = a,t,c or g

      <400> 223
 tagaannact gatagccgta cgcatgcgct accggtccgg aattcccggg tcgacgattt     60

 cgtcacccga acagtctctc ctcctcacag aagcctgtag ctgggcatcc aagaagaagc    120

 agcctcattt gttttctggt gtcatcgtag gtggccacct atggcttttg ggcttctcac    180

 ctggggcggg tgggttctgc accaccctcc caccctcctt cctccgtgtg gacgatagag    240

 ccacatccag caccacggac gtggggccca agcccccgtg aag  atg gtg tcc tgg     295
                                                  Met Val Ser Trp
                                                    1

 atg atc tcc aga gcc gtg gtg ctg gtg ttt gga atg ctt tat cct gca      343
 Met Ile Ser Arg Ala Val Val Leu Val Phe Gly Met Leu Tyr Pro Ala
   5                  10                  15                  20

 tat tat tca tac aaa gct gtg aaa aca aaa aac gtg aag gaa tat gtt      391
 Tyr Tyr Ser Tyr Lys Ala Val Lys Thr Lys Asn Val Lys Glu Tyr Val
                  25                  30                  35

 cga tgg atg atg tac tgg att gtt ttt gct ctc tat act gtg att gaa      439
 Arg Trp Met Met Tyr Trp Ile Val Phe Ala Leu Tyr Thr Val Ile Glu
              40                  45                  50

 aca gta gcc gat caa aca gtt gct tgg ttt ccc ctg tac tat gag ctg      487
 Thr Val Ala Asp Gln Thr Val Ala Trp Phe Pro Leu Tyr Tyr Glu Leu
          55                  60                  65

 aag att gct ttt gtc ata tgg ctg ctt tct ccc tat acc aaa gga gca      535
 Lys Ile Ala Phe Val Ile Trp Leu Leu Ser Pro Tyr Thr Lys Gly Ala
      70                  75                  80

 agt tta ata tat aga aaa ttc ctt cat cca ctt ctt tct tca aag gaa      583
 Ser Leu Ile Tyr Arg Lys Phe Leu His Pro Leu Leu Ser Ser Lys Glu
  85                  90                  95                 100

 agg gag att gat gat tat att gta caa gca aag gaa cga ggc tat gaa      631
 Arg Glu Ile Asp Asp Tyr Ile Val Gln Ala Lys Glu Arg Gly Tyr Glu
                 105                 110                 115

 acc atg gta aac ttt gga cgg caa ggt tta aac ctt gca gct act gct      679
 Thr Met Val Asn Phe Gly Arg Gln Gly Leu Asn Leu Ala Ala Thr Ala
             120                 125                 130

 gct gtt act gca gca gta aag agc caa gga gca ata act gaa cgt tta      727
 Ala Val Thr Ala Ala Val Lys Ser Gln Gly Ala Ile Thr Glu Arg Leu
         135                 140                 145

 aga agc ttc agt atg cat gat tta aca act atc caa ggt gat gag cct      775
 Arg Ser Phe Ser Met His Asp Leu Thr Thr Ile Gln Gly Asp Glu Pro
     150                 155                 160

 gtg gga caa aga cca tac caa cct cta cca gaa gca aaa aaa aaa aaa      823
 Val Gly Gln Arg Pro Tyr Gln Pro Leu Pro Glu Ala Lys Lys Lys Lys
 165                 170                 175                 180

 aaa agg cgg ccg ctc tag agtatc cctcgagggg cccaagctta agcgtaccca      877
 Lys Arg Arg Pro Leu 
                 185

 gctttcttgt acaaagtgg                                                 896




      <210> 224
      <211> 5022
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (261)..(4784)

      <400> 224
 aaaaagttat atccattagt acggcaagat agtgaggtgg cattatacaa taatcaaggt     60

 atgcatcaag aagggtacgg aggtcgaata cactacaacc gccccccagt gtgttggaat    120

 tcgcctttaa gcagtggtat ccctgcagag tacgcgggga gtccagcagc caccatcacc    180

 accactgcgg ttgctgctgc agctgcagct gctgctctcc ctccggctgc ttcttcgcgt    240

 ggccagcagc gaatggagcg    atg gag ccc aga ctg ttc tgc tgg acc act     290
                          Met Glu Pro Arg Leu Phe Cys Trp Thr Thr
                            1               5                  10

 ctc ttt ctc ctg gcc ggg tgg tgc ctg cca ggg ttg ccc tgc ccc agc      338
 Leu Phe Leu Leu Ala Gly Trp Cys Leu Pro Gly Leu Pro Cys Pro Ser
                  15                  20                  25

 cgg tgc ctt tgc ttt aag agc acc gtc cgc tgc atg cac ttg atg ctg      386
 Arg Cys Leu Cys Phe Lys Ser Thr Val Arg Cys Met His Leu Met Leu
              30                  35                  40

 gac cac att cct cag gta cca cag cag acc aca gtt cta gac ttg agg      434
 Asp His Ile Pro Gln Val Pro Gln Gln Thr Thr Val Leu Asp Leu Arg
          45                  50                  55

 ttt aac aga ata aga gaa att cca ggg agc gcc ttc aag aaa ctc aag      482
 Phe Asn Arg Ile Arg Glu Ile Pro Gly Ser Ala Phe Lys Lys Leu Lys
      60                  65                  70

 aat ttg aac aca ctt tac ctg tat aag aac cac atc aga aag att tcc      530
 Asn Leu Asn Thr Leu Tyr Leu Tyr Lys Asn His Ile Arg Lys Ile Ser
  75                  80                  85                  90

 aga aat gct ttt gaa gga ctt gaa aat ttg cta tat ctg tat att cat      578
 Arg Asn Ala Phe Glu Gly Leu Glu Asn Leu Leu Tyr Leu Tyr Ile His
                  95                 100                 105

 ttc aac caa cta gaa atg cta cag cca gag acc ttt gga gac ctt ctg      626
 Phe Asn Gln Leu Glu Met Leu Gln Pro Glu Thr Phe Gly Asp Leu Leu
             110                 115                 120

 aga tta gag cga cta ttt ttg cat aac aac aaa tta tct aaa att cca      674
 Arg Leu Glu Arg Leu Phe Leu His Asn Asn Lys Leu Ser Lys Ile Pro
         125                 130                 135

 gct ggg agc ttt tct aat ctg gat tca tta aaa aga ttg cgt ctg gat      722
 Ala Gly Ser Phe Ser Asn Leu Asp Ser Leu Lys Arg Leu Arg Leu Asp
     140                 145                 150

 tcc aac gcc ctg gtt tgt gac tgt gat ctg atg tgg ctg ggg gag ctt      770
 Ser Asn Ala Leu Val Cys Asp Cys Asp Leu Met Trp Leu Gly Glu Leu
 155                 160                 165                 170

 tta caa ggc ttt gcc caa cac ggc cac acc cag gct gcg gct acc tgc      818
 Leu Gln Gly Phe Ala Gln His Gly His Thr Gln Ala Ala Ala Thr Cys
                 175                 180                 185

 gaa tat ccc agg aga ctc cat ggg cgt gca gtt gct tca gta aca gta      866
 Glu Tyr Pro Arg Arg Leu His Gly Arg Ala Val Ala Ser Val Thr Val
             190                 195                 200

 gag gaa ttc aat tgc cag agc ccc cga att act ttt gag ccg cag gat      914
 Glu Glu Phe Asn Cys Gln Ser Pro Arg Ile Thr Phe Glu Pro Gln Asp
         205                 210                 215

 gtg gag gta cca tca gga aat acc gtc tac ttc acc tgc cgg gcg gaa      962
 Val Glu Val Pro Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu
     220                 225                 230

 gga aac ccc aaa cct gag att att tgg ata cac aac aac cac tca ttg     1010
 Gly Asn Pro Lys Pro Glu Ile Ile Trp Ile His Asn Asn His Ser Leu
 235                 240                 245                 250

 gat ttg gaa gat gat act cga ctt aat gtg ttt gat gat ggc aca ctc     1058
 Asp Leu Glu Asp Asp Thr Arg Leu Asn Val Phe Asp Asp Gly Thr Leu
                 255                 260                 265

 atg atc cga aac acc aga gag tca gac caa ggt gtc tat cag tgc atg     1106
 Met Ile Arg Asn Thr Arg Glu Ser Asp Gln Gly Val Tyr Gln Cys Met
             270                 275                 280

 gcc aga aat tcc gct ggg gaa gcc aag aca cag agt gcc atg ctc aga     1154
 Ala Arg Asn Ser Ala Gly Glu Ala Lys Thr Gln Ser Ala Met Leu Arg
         285                 290                 295

 tac tcc agt ctt cca gcc aaa cca ggc ttt gta atc cag cct cag gac     1202
 Tyr Ser Ser Leu Pro Ala Lys Pro Gly Phe Val Ile Gln Pro Gln Asp
     300                 305                 310

 aca gag gtt tta act ggc acc agc aca act ttg gaa tgt atg gcc aca     1250
 Thr Glu Val Leu Thr Gly Thr Ser Thr Thr Leu Glu Cys Met Ala Thr
 315                 320                 325                 330

 ggc cac cca cac cct ctt atc act tgg acc agg gac aat gga ttg gag     1298
 Gly His Pro His Pro Leu Ile Thr Trp Thr Arg Asp Asn Gly Leu Glu
                 335                 340                 345

 ttg gat gga tcc agg cat gtg gca acg tcc agt gga ctt tac tta cag     1346
 Leu Asp Gly Ser Arg His Val Ala Thr Ser Ser Gly Leu Tyr Leu Gln
             350                 355                 360

 aac atc aca caa cgg gat cat ggt cga ttt acc tgt cat gcc aac aat     1394
 Asn Ile Thr Gln Arg Asp His Gly Arg Phe Thr Cys His Ala Asn Asn
         365                 370                 375

 agc cac ggc act gtt caa gct gca gca aac ata att gta caa gct cct     1442
 Ser His Gly Thr Val Gln Ala Ala Ala Asn Ile Ile Val Gln Ala Pro
     380                 385                 390

 cca caa ttt aca gta acc ccc aag gat caa gtg gtg ctg gaa gaa cat     1490
 Pro Gln Phe Thr Val Thr Pro Lys Asp Gln Val Val Leu Glu Glu His
 395                 400                 405                 410

 gct gta gag tgg ctc tgt gaa gct gac ggc aac cca cct cct gtt att     1538
 Ala Val Glu Trp Leu Cys Glu Ala Asp Gly Asn Pro Pro Pro Val Ile
                 415                 420                 425

 gtc tgg aca aaa aca ggt att aga aca tct gca gga ggg cag ctc cct     1586
 Val Trp Thr Lys Thr Gly Ile Arg Thr Ser Ala Gly Gly Gln Leu Pro
             430                 435                 440

 gtg gaa ggc cag cat aca gtt ctc tcc tct ggc act ttg aga att gac     1634
 Val Glu Gly Gln His Thr Val Leu Ser Ser Gly Thr Leu Arg Ile Asp
         445                 450                 455

 cgt gca gca cag cac gat caa ggc caa tat gaa tgt caa gca gtc agt     1682
 Arg Ala Ala Gln His Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser
     460                 465                 470

 tcg ttg ggg gtg aaa aag gtg tct gtg cag ctg act gta aaa ccc aaa     1730
 Ser Leu Gly Val Lys Lys Val Ser Val Gln Leu Thr Val Lys Pro Lys
 475                 480                 485                 490

 ggc cct agc agc aac act aag aca gct gga aaa gcc ccc tta ata ccc     1778
 Gly Pro Ser Ser Asn Thr Lys Thr Ala Gly Lys Ala Pro Leu Ile Pro
                 495                 500                 505

 tgc tgt gtt ttc agg ccc ttc ctg gtc tca gct ctt gca gtg ttt act     1826
 Cys Cys Val Phe Arg Pro Phe Leu Val Ser Ala Leu Ala Val Phe Thr
             510                 515                 520

 caa ctt cct cag gat aca agt gtc gag gtt gga aag aat ata aac att     1874
 Gln Leu Pro Gln Asp Thr Ser Val Glu Val Gly Lys Asn Ile Asn Ile
         525                 530                 535

 tca tgt cat gct caa gga gaa cca cag ccc ata att act tgg aat aag     1922
 Ser Cys His Ala Gln Gly Glu Pro Gln Pro Ile Ile Thr Trp Asn Lys
     540                 545                 550

 gaa ggt gtg aag att act gag agt ggt aaa ttc cat gtg gat gat gaa     1970
 Glu Gly Val Lys Ile Thr Glu Ser Gly Lys Phe His Val Asp Asp Glu
 555                 560                 565                 570

 ggc acg ttg act atc tac gac gca ggg ttc cct gac cag gga aga tat     2018
 Gly Thr Leu Thr Ile Tyr Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr
                 575                 580                 585

 gaa tgt gtg gct cgg aat tct ttt ggc ctt gct gtg acc aac atg ttt     2066
 Glu Cys Val Ala Arg Asn Ser Phe Gly Leu Ala Val Thr Asn Met Phe
             590                 595                 600

 ctt aca gtc acg ggc tgt gac cag tat tgg ggg ttg ggg acc tct gtc     2114
 Leu Thr Val Thr Gly Cys Asp Gln Tyr Trp Gly Leu Gly Thr Ser Val
         605                 610                 615

 ata gga tct tcg aac ctc agt gag gag cac gga ttt att ctg aag gcg     2162
 Ile Gly Ser Ser Asn Leu Ser Glu Glu His Gly Phe Ile Leu Lys Ala
     620                 625                 630

 ctg ggg ttg gga acc cct ggt cta gct ata cag ggt aga caa gct ggc     2210
 Leu Gly Leu Gly Thr Pro Gly Leu Ala Ile Gln Gly Arg Gln Ala Gly
 635                 640                 645                 650

 gat gac ttt gtt gaa tct tcc att ctt gat gct gta cag aga gtt gac     2258
 Asp Asp Phe Val Glu Ser Ser Ile Leu Asp Ala Val Gln Arg Val Asp
                 655                 660                 665

 agt gca att aac tcc aca cga aga cat ttg ttt tca caa aaa cct cac     2306
 Ser Ala Ile Asn Ser Thr Arg Arg His Leu Phe Ser Gln Lys Pro His
             670                 675                 680

 acc tcc agt gac ctg ctg gct caa ttt cat tac ccg cgt gac cca ctg     2354
 Thr Ser Ser Asp Leu Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu
         685                 690                 695

 att gtg gaa atg gca aga gca ggg gag att ttt gag cac acg ctg cag     2402
 Ile Val Glu Met Ala Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln
     700                 705                 710

 ctg ata cgg gaa cgt gtg aag cag ggg ctc act gtg gac ttg gaa ggc     2450
 Leu Ile Arg Glu Arg Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly
 715                 720                 725                 730

 aaa gaa ttc cgg tac aat gac ttg gtg tcc ccg cgc tcc ctc agc ctc     2498
 Lys Glu Phe Arg Tyr Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu
                 735                 740                 745

 atc gcc aat tta tct gga tgc aca gct cgc agg cct ctg cca aac tgc     2546
 Ile Ala Asn Leu Ser Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys
             750                 755                 760

 tcc aac cgg tgt ttc cat gcg aag tac cgc gcc cac gac ggc acg tgc     2594
 Ser Asn Arg Cys Phe His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys
         765                 770                 775

 aac aac ctg cag cag ccc acg tgg ggc gcg gcg ctg acc gcc ttc gcg     2642
 Asn Asn Leu Gln Gln Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala
     780                 785                 790

 cgc ctg ctg cag cca gcc tac cgg gac ggc atc cgc gcg ccc cgc ggg     2690
 Arg Leu Leu Gln Pro Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly
 795                 800                 805                 810

 ctc ggc ctt cct gtg ggc tcc cgc cag ccc ctc ccg ccg ccc cgg ctg     2738
 Leu Gly Leu Pro Val Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu
                 815                 820                 825

 gtc gcc aca gtg tgg gcg cgc gcg gcg gcc gtc acc ccc gac cac agc     2786
 Val Ala Thr Val Trp Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser
             830                 835                 840

 tac acg cgc atg ctc atg cac tgg ggc tgg ttt cta gag cac gac ttg     2834
 Tyr Thr Arg Met Leu Met His Trp Gly Trp Phe Leu Glu His Asp Leu
         845                 850                 855

 gac cac aca gtg cct gcg ctg agc aca gcc cgc ttc tcg gat ggg cgg     2882
 Asp His Thr Val Pro Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg
     860                 865                 870

 ccg tgc agc tcc gtc tgc acc aac gac cct cct tgt ttc ccc atg aac     2930
 Pro Cys Ser Ser Val Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn
 875                 880                 885                 890

 acc cgg cac gcc gac ccc cgg ggc acc cac gcg ccc tgc atg ctc ttc     2978
 Thr Arg His Ala Asp Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe
                 895                 900                 905

 gcg cgc tcc agc ccc gcg tgt gcc agc ggc cgt ccc tct gcg acg gtg     3026
 Ala Arg Ser Ser Pro Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val
             910                 915                 920

 gat tca gtc tat gca cga gag cag atc aac cag caa aca gcc tac atc     3074
 Asp Ser Val Tyr Ala Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile
         925                 930                 935

 gat ggc tcc aac gtt tac ggg agc tcg gag cgg gaa tcc cag gct ctc     3122
 Asp Gly Ser Asn Val Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu
     940                 945                 950

 aga gac cct tcg gtg cct cgg ggt ctc ctg aag aca ggc ttt cct tgg     3170
 Arg Asp Pro Ser Val Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp
 955                 960                 965                 970

 cct ccc tcc gga aag ccc tta ttg ccc ttt tct aca ggc cca ccc acc     3218
 Pro Pro Ser Gly Lys Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr
                 975                 980                 985

 gag tgc gcg cga cag gag cag gag agc ccc tgt ttc ctg gcc ggg gac     3266
 Glu Cys Ala Arg Gln Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp
             990                 995                1000

 cac cgg gcc aac gag cat ctg gct ctg gcc gcc atg cac acc ctg tgg     3314
 His Arg Ala Asn Glu His Leu Ala Leu Ala Ala Met His Thr Leu Trp
        1005                1010                1015

 ttc cgg gaa cac aac agg gtg gcc acg gag ctg tcc gcc ctg aac ccc     3362
 Phe Arg Glu His Asn Arg Val Ala Thr Glu Leu Ser Ala Leu Asn Pro
    1020                1025                1030

 cac tgg gag gga aac acg gtt tac cag gaa gcc agg aag atc gtg ggc     3410
 His Trp Glu Gly Asn Thr Val Tyr Gln Glu Ala Arg Lys Ile Val Gly
1035                1040                1045                1050

 gcg gag ctg cag cac atc acc tac agc cac tgg ctg cct aag gtc ctg     3458
 Ala Glu Leu Gln His Ile Thr Tyr Ser His Trp Leu Pro Lys Val Leu
                1055                1060                1065

 ggg gac cct ggc act agg atg ctg agg ggt tac cga ggc tac aac ccc     3506
 Gly Asp Pro Gly Thr Arg Met Leu Arg Gly Tyr Arg Gly Tyr Asn Pro
            1070                1075                1080

 aac gtg aat gca ggc atc att aac tct ttt gct act gca gcc ttt aga     3554
 Asn Val Asn Ala Gly Ile Ile Asn Ser Phe Ala Thr Ala Ala Phe Arg
        1085                1090                1095

 ttt ggc cac aca tta atc aat cct att ctt tac cga ctg aat gcc acc     3602
 Phe Gly His Thr Leu Ile Asn Pro Ile Leu Tyr Arg Leu Asn Ala Thr
    1100                1105                1110

 tta ggt gaa att tcc gaa ggc cac ctt ccg ttc cat aaa gcg ctc ttt     3650
 Leu Gly Glu Ile Ser Glu Gly His Leu Pro Phe His Lys Ala Leu Phe
1115                1120                1125                1130

 tca ccg tcc aga ata atc aag gaa ggt ggg ata gac ccg gtt ctc cgg     3698
 Ser Pro Ser Arg Ile Ile Lys Glu Gly Gly Ile Asp Pro Val Leu Arg
                1135                1140                1145

 ggg ctg ttt ggc gtg gct gct aaa tgg cgg gca ccc tcc tac ctt ctc     3746
 Gly Leu Phe Gly Val Ala Ala Lys Trp Arg Ala Pro Ser Tyr Leu Leu
            1150                1155                1160

 agt cct gag ctg acc cag agg ctc ttc tcc gcg gct tat tct gcg gcc     3794
 Ser Pro Glu Leu Thr Gln Arg Leu Phe Ser Ala Ala Tyr Ser Ala Ala
        1165                1170                1175

 gtg gat tcg gct gcc acc atc att caa agg ggt aga gac cac ggg atc     3842
 Val Asp Ser Ala Ala Thr Ile Ile Gln Arg Gly Arg Asp His Gly Ile
    1180                1185                1190

 cca cca tat gtt gac ttc aga gtt ttc tgt aat ttg act tca gtt aag     3890
 Pro Pro Tyr Val Asp Phe Arg Val Phe Cys Asn Leu Thr Ser Val Lys
1195                1200                1205                1210

 aac ttt gag gat ctt caa aat gaa att aaa gat tca gag att aga caa     3938
 Asn Phe Glu Asp Leu Gln Asn Glu Ile Lys Asp Ser Glu Ile Arg Gln
                1215                1220                1225

 aaa ctg aga aag ttg tac ggc tct cca ggt gac att gac ctc tgg ccc     3986
 Lys Leu Arg Lys Leu Tyr Gly Ser Pro Gly Asp Ile Asp Leu Trp Pro
            1230                1235                1240

 gcc ctt atg gtt gaa gac ctg att cct ggt aca aga gtg gga cca aca     4034
 Ala Leu Met Val Glu Asp Leu Ile Pro Gly Thr Arg Val Gly Pro Thr
        1245                1250                1255

 ctt atg tgc ctg ttt gtt acc cag ttt cag cgg cta aga gat gga gat     4082
 Leu Met Cys Leu Phe Val Thr Gln Phe Gln Arg Leu Arg Asp Gly Asp
    1260                1265                1270

 agg ttc tgg tat gaa aac cct gga gta ttt acc ccg gca caa ctc act     4130
 Arg Phe Trp Tyr Glu Asn Pro Gly Val Phe Thr Pro Ala Gln Leu Thr
1275                1280                1285                1290

 cag ctg aag cag gcg tcc ctg agc cgg gtg ctt tgt gac aat ggt gac     4178
 Gln Leu Lys Gln Ala Ser Leu Ser Arg Val Leu Cys Asp Asn Gly Asp
                1295                1300                1305

 agc att cag caa gtg cag gct gat gtc ttt gta aag gca gaa tac cca     4226
 Ser Ile Gln Gln Val Gln Ala Asp Val Phe Val Lys Ala Glu Tyr Pro
            1310                1315                1320

 cag gat tac ctg aac tgc agc gag atc ccg aag gtg gac ctg cga gtg     4274
 Gln Asp Tyr Leu Asn Cys Ser Glu Ile Pro Lys Val Asp Leu Arg Val
        1325                1330                1335

 tgg caa gac tgc tgt gca gac tgt agg agt aga gga cag ttc aga gca     4322
 Trp Gln Asp Cys Cys Ala Asp Cys Arg Ser Arg Gly Gln Phe Arg Ala
    1340                1345                1350

 gtg acg caa gag tct caa aag aaa cgc tca gct caa tac agc tat cct     4370
 Val Thr Gln Glu Ser Gln Lys Lys Arg Ser Ala Gln Tyr Ser Tyr Pro
1355                1360                1365                1370

 gtt gat aag gat atg gag tta agt cat cta aga agt agg caa caa gat     4418
 Val Asp Lys Asp Met Glu Leu Ser His Leu Arg Ser Arg Gln Gln Asp
                1375                1380                1385

 aaa ata tat gtg ggt gaa gat gct aga aat gtg aca gtt ctg gca aaa     4466
 Lys Ile Tyr Val Gly Glu Asp Ala Arg Asn Val Thr Val Leu Ala Lys
            1390                1395                1400

 aca aag ttc tcc caa gat ttc agc acg ttt gca gcg gaa att cag gaa     4514
 Thr Lys Phe Ser Gln Asp Phe Ser Thr Phe Ala Ala Glu Ile Gln Glu
        1405                1410                1415

 acc atc aca gca ctc aga gag cag ata aac aag ctg gag gca cgc ctg     4562
 Thr Ile Thr Ala Leu Arg Glu Gln Ile Asn Lys Leu Glu Ala Arg Leu
    1420                1425                1430

 agg cag gca ggg tgt aca gat gtt aga ggg gtt cca agg aag gcc gag     4610
 Arg Gln Ala Gly Cys Thr Asp Val Arg Gly Val Pro Arg Lys Ala Glu
1435                1440                1445                1450

 gag cgc tgg atg aaa gaa gac tgc act cac tgc att tgt gag agt ggc     4658
 Glu Arg Trp Met Lys Glu Asp Cys Thr His Cys Ile Cys Glu Ser Gly
                1455                1460                1465

 cag gtc acc tgt gtg gtg gag att tgt ccc ccg gct ccc tgt ccc agt     4706
 Gln Val Thr Cys Val Val Glu Ile Cys Pro Pro Ala Pro Cys Pro Ser
            1470                1475                1480

 cct gaa ttg gtg aaa gga acc tgc tgt cca gtt tgc aga gac cga gga     4754
 Pro Glu Leu Val Lys Gly Thr Cys Cys Pro Val Cys Arg Asp Arg Gly
        1485                1490                1495

 atg cca agt gat tcc cca gag aag cgc taa t aaaagttttg tgctgttgag     4805
 Met Pro Ser Asp Ser Pro Glu Lys Arg 
    1500                1505

 ccccaaatgg gaaatttctc aggaagagac atttaggact tcagaacttt taacttgtag   4865

 tcacattgtt gatatggaaa ccactgactt aagcaactta gttcatctaa tcttacatat   4925

 acttacgatc ttttattttt tcattttcta acataccttg aaataattca aaactaaaag   4985

 caataaagtg catatgaagt gtttgatcat aagaaat                            5022




      <210> 225
      <211> 4866
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(4628)

      <400> 225
 cggcgccagg g atg gat atc tgc aga acc tgc ctt cgt aga cga ctc act      50
              Met Asp Ile Cys Arg Thr Cys Leu Arg Arg Arg Leu Thr
                1               5                  10

 ata tgc tgc tct ccc tcc ggc tgc ttc ttc gcg tgg cca gca gcg aat       98
 Ile Cys Cys Ser Pro Ser Gly Cys Phe Phe Ala Trp Pro Ala Ala Asn
      15                  20                  25

 gga gcg atg gag ccc aga ctg ttc tgc tgg acc act ctc ttt ctc ctg      146
 Gly Ala Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu
  30                  35                  40                  45

 gcc ggg tgg tgc ctg cca ggg ttg ccc tgc ccc agc cgg tgc ctt tgc      194
 Ala Gly Trp Cys Leu Pro Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys
                  50                  55                  60

 ttt aag agc acc gtc cgc tgc atg cac ttg atg ctg gac cac att cct      242
 Phe Lys Ser Thr Val Arg Cys Met His Leu Met Leu Asp His Ile Pro
              65                  70                  75

 cag gta cca cag cag acc aca gtt cta gac ttg agg ttt aac aga ata      290
 Gln Val Pro Gln Gln Thr Thr Val Leu Asp Leu Arg Phe Asn Arg Ile
          80                  85                  90

 aga gaa att cca ggg agc gcc ttc aag aaa ctc aag aat ttg aac aca      338
 Arg Glu Ile Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr
      95                 100                 105

 ctt tac ctg tat aag aac cac atc aga aag att tcc aga aat gct ttt      386
 Leu Tyr Leu Tyr Lys Asn His Ile Arg Lys Ile Ser Arg Asn Ala Phe
 110                 115                 120                 125

 gaa gga ctt gaa aat ttg cta tat ctg tat att cat ttc aac caa cta      434
 Glu Gly Leu Glu Asn Leu Leu Tyr Leu Tyr Ile His Phe Asn Gln Leu
                 130                 135                 140

 gaa atg cta cag cca gag acc ttt gga gac ctt ctg aga tta gag cga      482
 Glu Met Leu Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg
             145                 150                 155

 cta ttt ttg cat aac aac aaa tta tct aaa att cca gct ggg agc ttt      530
 Leu Phe Leu His Asn Asn Lys Leu Ser Lys Ile Pro Ala Gly Ser Phe
         160                 165                 170

 tct aat ctg gat tca tta aaa aga ttg cgt ctg gat tcc aac gcc ctg      578
 Ser Asn Leu Asp Ser Leu Lys Arg Leu Arg Leu Asp Ser Asn Ala Leu
     175                 180                 185

 gtt tgt gac tgt gat ctg atg tgg ctg ggg gag ctt tta caa ggc ttt      626
 Val Cys Asp Cys Asp Leu Met Trp Leu Gly Glu Leu Leu Gln Gly Phe
 190                 195                 200                 205

 gcc caa cac ggc cac acc cag gct gcg gct acc tgc gaa tat ccc agg      674
 Ala Gln His Gly His Thr Gln Ala Ala Ala Thr Cys Glu Tyr Pro Arg
                 210                 215                 220

 aga ctc cat ggg cgt gca gtt gct tca gta aca gta gag gaa ttc aat      722
 Arg Leu His Gly Arg Ala Val Ala Ser Val Thr Val Glu Glu Phe Asn
             225                 230                 235

 tgc cag agc ccc cga att act ttt gag ccg cag gat gtg gag gta cca      770
 Cys Gln Ser Pro Arg Ile Thr Phe Glu Pro Gln Asp Val Glu Val Pro
         240                 245                 250

 tca gga aat acc gtc tac ttc acc tgc cgg gcg gaa gga aac ccc aaa      818
 Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys
     255                 260                 265

 cct gag att att tgg ata cac aac aac cac tca ttg gat ttg gaa gat      866
 Pro Glu Ile Ile Trp Ile His Asn Asn His Ser Leu Asp Leu Glu Asp
 270                 275                 280                 285

 gat act cga ctt aat gtg ttt gat gat ggc aca ctc atg atc cga aac      914
 Asp Thr Arg Leu Asn Val Phe Asp Asp Gly Thr Leu Met Ile Arg Asn
                 290                 295                 300

 acc aga gag tca gac caa ggt gtc tat cag tgc atg gcc aga aat tcc      962
 Thr Arg Glu Ser Asp Gln Gly Val Tyr Gln Cys Met Ala Arg Asn Ser
             305                 310                 315

 gct ggg gaa gcc aag aca cag agt gcc atg ctc aga tac tcc agt ctt     1010
 Ala Gly Glu Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu
         320                 325                 330

 cca gcc aaa cca ggc ttt gta atc cag cct cag gac aca gag gtt tta     1058
 Pro Ala Lys Pro Gly Phe Val Ile Gln Pro Gln Asp Thr Glu Val Leu
     335                 340                 345

 act ggc acc agc aca act ttg gaa tgt atg gcc aca ggc cac cca cac     1106
 Thr Gly Thr Ser Thr Thr Leu Glu Cys Met Ala Thr Gly His Pro His
 350                 355                 360                 365

 cct ctt atc act tgg acc agg gac aat gga ttg gag ttg gat gga tcc     1154
 Pro Leu Ile Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser
                 370                 375                 380

 agg cat gtg gca acg tcc agt gga ctt tac tta cag aac atc aca caa     1202
 Arg His Val Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln
             385                 390                 395

 cgg gat cat ggt cga ttt acc tgt cat gcc aac aat agc cac ggc act     1250
 Arg Asp His Gly Arg Phe Thr Cys His Ala Asn Asn Ser His Gly Thr
         400                 405                 410

 gtt caa gct gca gca aac ata att gta caa gct cct cca caa ttt aca     1298
 Val Gln Ala Ala Ala Asn Ile Ile Val Gln Ala Pro Pro Gln Phe Thr
     415                 420                 425

 gta acc ccc aag gat caa gtg gtg ctg gaa gaa cat gct gta gag tgg     1346
 Val Thr Pro Lys Asp Gln Val Val Leu Glu Glu His Ala Val Glu Trp
 430                 435                 440                 445

 ctc tgt gaa gct gac ggc aac cca cct cct gtt att gtc tgg aca aaa     1394
 Leu Cys Glu Ala Asp Gly Asn Pro Pro Pro Val Ile Val Trp Thr Lys
                 450                 455                 460

 aca ggt att aga aca tct gca gga ggg cag ctc cct gtg gaa ggc cag     1442
 Thr Gly Ile Arg Thr Ser Ala Gly Gly Gln Leu Pro Val Glu Gly Gln
             465                 470                 475

 cat aca gtt ctc tcc tct ggc act ttg aga att gac cgt gca gca cag     1490
 His Thr Val Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala Gln
         480                 485                 490

 cac gat caa ggc caa tat gaa tgt caa gca gtc agt tcg ttg ggg gtg     1538
 His Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly Val
     495                 500                 505

 aaa aag gtg tct gtg cag ctg act gta aaa ccc aaa ggc cct agc agc     1586
 Lys Lys Val Ser Val Gln Leu Thr Val Lys Pro Lys Gly Pro Ser Ser
 510                 515                 520                 525

 aac act aag aca gct gga aaa gcc ccc tta ata ccc tgc tgt gtt ttc     1634
 Asn Thr Lys Thr Ala Gly Lys Ala Pro Leu Ile Pro Cys Cys Val Phe
                 530                 535                 540

 agg ccc ttc ctg gtc tca gct ctt gca gtg ttt act caa ctt cct cag     1682
 Arg Pro Phe Leu Val Ser Ala Leu Ala Val Phe Thr Gln Leu Pro Gln
             545                 550                 555

 gat aca agt gtc gag gtt gga aag aat ata aac att tca tgt cat gct     1730
 Asp Thr Ser Val Glu Val Gly Lys Asn Ile Asn Ile Ser Cys His Ala
         560                 565                 570

 caa gga gaa cca cag ccc ata att act tgg aat aag gaa ggt gtg aag     1778
 Gln Gly Glu Pro Gln Pro Ile Ile Thr Trp Asn Lys Glu Gly Val Lys
     575                 580                 585

 att act gag agt ggt aaa ttc cat gtg gat gat gaa ggc acg ttg act     1826
 Ile Thr Glu Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr
 590                 595                 600                 605

 atc tac gac gca ggg ttc cct gac cag gga aga tat gaa tgt gtg gct     1874
 Ile Tyr Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala
                 610                 615                 620

 cgg aat tct ttt ggc ctt gct gtg acc aac atg ttt ctt aca gtc acg     1922
 Arg Asn Ser Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr
             625                 630                 635

 ggc tgt gac cag tat tgg ggg ttg ggg acc tct gtc ata gga tct tcg     1970
 Gly Cys Asp Gln Tyr Trp Gly Leu Gly Thr Ser Val Ile Gly Ser Ser
         640                 645                 650

 aac ctc agt gag gag cac gga ttt att ctg aag gcg ctg ggg ttg gga     2018
 Asn Leu Ser Glu Glu His Gly Phe Ile Leu Lys Ala Leu Gly Leu Gly
     655                 660                 665

 acc cct ggt cta gct ata cag ggt aga caa gct ggc gat gac ttt gtt     2066
 Thr Pro Gly Leu Ala Ile Gln Gly Arg Gln Ala Gly Asp Asp Phe Val
 670                 675                 680                 685

 gaa tct tcc att ctt gat gct gta cag aga gtt gac agt gca att aac     2114
 Glu Ser Ser Ile Leu Asp Ala Val Gln Arg Val Asp Ser Ala Ile Asn
                 690                 695                 700

 tcc aca cga aga cat ttg ttt tca caa aaa cct cac acc tcc agt gac     2162
 Ser Thr Arg Arg His Leu Phe Ser Gln Lys Pro His Thr Ser Ser Asp
             705                 710                 715

 ctg ctg gct caa ttt cat tac ccg cgt gac cca ctg att gtg gaa atg     2210
 Leu Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile Val Glu Met
         720                 725                 730

 gca aga gca ggg gag att ttt gag cac acg ctg cag ctg ata cgg gaa     2258
 Ala Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu Ile Arg Glu
     735                 740                 745

 cgt gtg aag cag ggg ctc act gtg gac ttg gaa ggc aaa gaa ttc cgg     2306
 Arg Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys Glu Phe Arg
 750                 755                 760                 765

 tac aat gac ttg gtg tcc ccg cgc tcc ctc agc ctc atc gcc aat tta     2354
 Tyr Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu
                 770                 775                 780

 tct gga tgc aca gct cgc agg cct ctg cca aac tgc tcc aac cgg tgt     2402
 Ser Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys
             785                 790                 795

 ttc cat gcg aag tac cgc gcc cac gac ggc acg tgc aac aac ctg cag     2450
 Phe His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn Asn Leu Gln
         800                 805                 810

 cag ccc acg tgg ggc gcg gcg ctg acc gcc ttc gcg cgc ctg ctg cag     2498
 Gln Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln
     815                 820                 825

 cca gcc tac cgg gac ggc atc cgc gcg ccc cgc ggg ctc ggc ctt cct     2546
 Pro Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro
 830                 835                 840                 845

 gtg ggc tcc cgc cag ccc ctc ccg ccg ccc cgg ctg gtc gcc aca gtg     2594
 Val Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val Ala Thr Val
                 850                 855                 860

 tgg gcg cgc gcg gcg gcc gtc acc ccc gac cac agc tac acg cgc atg     2642
 Trp Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr Thr Arg Met
             865                 870                 875

 ctc atg cac tgg ggc tgg ttt cta gag cac gac ttg gac cac aca gtg     2690
 Leu Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp His Thr Val
         880                 885                 890

 cct gcg ctg agc aca gcc cgc ttc tcg gat ggg cgg ccg tgc agc tcc     2738
 Pro Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser
     895                 900                 905

 gtc tgc acc aac gac cct cct tgt ttc ccc atg aac acc cgg cac gcc     2786
 Val Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr Arg His Ala
 910                 915                 920                 925

 gac ccc cgg ggc acc cac gcg ccc tgc atg ctc ttc gcg cgc tcc agc     2834
 Asp Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala Arg Ser Ser
                 930                 935                 940

 ccc gcg tgt gcc agc ggc cgt ccc tct gcg acg gtg gat tca gtc tat     2882
 Pro Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp Ser Val Tyr
             945                 950                 955

 gca cga gag cag atc aac cag caa aca gcc tac atc gat ggc tcc aac     2930
 Ala Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn
         960                 965                 970

 gtt tac ggg agc tcg gag cgg gaa tcc cag gct ctc aga gac cct tcg     2978
 Val Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser
     975                 980                 985

 gtg cct cgg ggt ctc ctg aag aca ggc ttt cct tgg cct ccc tcc gga     3026
 Val Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro Pro Ser Gly
 990                 995                1000                1005

 aag ccc tta ttg ccc ttt tct aca ggc cca ccc acc gag tgc gcg cga     3074
 Lys Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu Cys Ala Arg
                1010                1015                1020

 cag gag cag gag agc ccc tgt ttc ctg gcc ggg gac cac cgg gcc aac     3122
 Gln Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His Arg Ala Asn
            1025                1030                1035

 gag cat ctg gct ctg gcc gcc atg cac acc ctg tgg ttc cgg gaa cac     3170
 Glu His Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe Arg Glu His
        1040                1045                1050

 aac agg gtg gcc acg gag ctg tcc gcc ctg aac ccc cac tgg gag gga     3218
 Asn Arg Val Ala Thr Glu Leu Ser Ala Leu Asn Pro His Trp Glu Gly
    1055                1060                1065

 aac acg gtt tac cag gaa gcc agg aag atc gtg ggc gcg gag ctg cag     3266
 Asn Thr Val Tyr Gln Glu Ala Arg Lys Ile Val Gly Ala Glu Leu Gln
1070                1075                1080                1085

 cac atc acc tac agc cac tgg ctg cct aag gtc ctg ggg gac cct ggc     3314
 His Ile Thr Tyr Ser His Trp Leu Pro Lys Val Leu Gly Asp Pro Gly
                1090                1095                1100

 act agg atg ctg agg ggt tac cga ggc tac aac ccc aac gtg aat gca     3362
 Thr Arg Met Leu Arg Gly Tyr Arg Gly Tyr Asn Pro Asn Val Asn Ala
            1105                1110                1115

 ggc atc att aac tct ttt gct act gca gcc ttt aga ttt ggc cac aca     3410
 Gly Ile Ile Asn Ser Phe Ala Thr Ala Ala Phe Arg Phe Gly His Thr
        1120                1125                1130

 tta atc aat cct att ctt tac cga ctg aat gcc acc tta ggt gaa att     3458
 Leu Ile Asn Pro Ile Leu Tyr Arg Leu Asn Ala Thr Leu Gly Glu Ile
    1135                1140                1145

 tcc gaa ggc cac ctt ccg ttc cat aaa gcg ctc ttt tca ccg tcc aga     3506
 Ser Glu Gly His Leu Pro Phe His Lys Ala Leu Phe Ser Pro Ser Arg
1150                1155                1160                1165

 ata atc aag gaa ggt ggg ata gac ccg gtt ctc cgg ggg ctg ttt ggc     3554
 Ile Ile Lys Glu Gly Gly Ile Asp Pro Val Leu Arg Gly Leu Phe Gly
                1170                1175                1180

 gtg gct gct aaa tgg cgg gca ccc tcc tac ctt ctc agt cct gag ctg     3602
 Val Ala Ala Lys Trp Arg Ala Pro Ser Tyr Leu Leu Ser Pro Glu Leu
            1185                1190                1195

 acc cag agg ctc ttc tcc gcg gct tat tct gcg gcc gtg gat tcg gct     3650
 Thr Gln Arg Leu Phe Ser Ala Ala Tyr Ser Ala Ala Val Asp Ser Ala
        1200                1205                1210

 gcc acc atc att caa agg ggt aga gac cac ggg atc cca cca tat gtt     3698
 Ala Thr Ile Ile Gln Arg Gly Arg Asp His Gly Ile Pro Pro Tyr Val
    1215                1220                1225

 gac ttc aga gtt ttc tgt aat ttg act tca gtt aag aac ttt gag gat     3746
 Asp Phe Arg Val Phe Cys Asn Leu Thr Ser Val Lys Asn Phe Glu Asp
1230                1235                1240                1245

 ctt caa aat gaa att aaa gat tca gag att aga caa aaa ctg aga aag     3794
 Leu Gln Asn Glu Ile Lys Asp Ser Glu Ile Arg Gln Lys Leu Arg Lys
                1250                1255                1260

 ttg tac ggc tct cca ggt gac att gac ctc tgg ccc gcc ctt atg gtt     3842
 Leu Tyr Gly Ser Pro Gly Asp Ile Asp Leu Trp Pro Ala Leu Met Val
            1265                1270                1275

 gaa gac ctg att cct ggt aca aga gtg gga cca aca ctt atg tgc ctg     3890
 Glu Asp Leu Ile Pro Gly Thr Arg Val Gly Pro Thr Leu Met Cys Leu
        1280                1285                1290

 ttt gtt acc cag ttt cag cgg cta aga gat gga gat agg ttc tgg tat     3938
 Phe Val Thr Gln Phe Gln Arg Leu Arg Asp Gly Asp Arg Phe Trp Tyr
    1295                1300                1305

 gaa aac cct gga gta ttt acc ccg gca caa ctc act cag ctg aag cag     3986
 Glu Asn Pro Gly Val Phe Thr Pro Ala Gln Leu Thr Gln Leu Lys Gln
1310                1315                1320                1325

 gcg tcc ctg agc cgg gtg ctt tgt gac aat ggt gac agc att cag caa     4034
 Ala Ser Leu Ser Arg Val Leu Cys Asp Asn Gly Asp Ser Ile Gln Gln
                1330                1335                1340

 gtg cag gct gat gtc ttt gta aag gca gaa tac cca cag gat tac ctg     4082
 Val Gln Ala Asp Val Phe Val Lys Ala Glu Tyr Pro Gln Asp Tyr Leu
            1345                1350                1355

 aac tgc agc gag atc ccg aag gtg gac ctg cga gtg tgg caa gac tgc     4130
 Asn Cys Ser Glu Ile Pro Lys Val Asp Leu Arg Val Trp Gln Asp Cys
        1360                1365                1370

 tgt gca gac tgt agg agt aga gga cag ttc aga gca gtg acg caa gag     4178
 Cys Ala Asp Cys Arg Ser Arg Gly Gln Phe Arg Ala Val Thr Gln Glu
    1375                1380                1385

 tct caa aag aaa cgc tca gct caa tac agc tat cct gtt gat aag gat     4226
 Ser Gln Lys Lys Arg Ser Ala Gln Tyr Ser Tyr Pro Val Asp Lys Asp
1390                1395                1400                1405

 atg gag tta agt cat cta aga agt agg caa caa gat aaa ata tat gtg     4274
 Met Glu Leu Ser His Leu Arg Ser Arg Gln Gln Asp Lys Ile Tyr Val
                1410                1415                1420

 ggt gaa gat gct aga aat gtg aca gtt ctg gca aaa aca aag ttc tcc     4322
 Gly Glu Asp Ala Arg Asn Val Thr Val Leu Ala Lys Thr Lys Phe Ser
            1425                1430                1435

 caa gat ttc agc acg ttt gca gcg gaa att cag gaa acc atc aca gca     4370
 Gln Asp Phe Ser Thr Phe Ala Ala Glu Ile Gln Glu Thr Ile Thr Ala
        1440                1445                1450

 ctc aga gag cag ata aac aag ctg gag gca cgc ctg agg cag gca ggg     4418
 Leu Arg Glu Gln Ile Asn Lys Leu Glu Ala Arg Leu Arg Gln Ala Gly
    1455                1460                1465

 tgt aca gat gtt aga ggg gtt cca agg aag gcc gag gag cgc tgg atg     4466
 Cys Thr Asp Val Arg Gly Val Pro Arg Lys Ala Glu Glu Arg Trp Met
1470                1475                1480                1485

 aaa gaa gac tgc act cac tgc att tgt gag agt ggc cag gtc acc tgt     4514
 Lys Glu Asp Cys Thr His Cys Ile Cys Glu Ser Gly Gln Val Thr Cys
                1490                1495                1500

 gtg gtg gag att tgt ccc ccg gct ccc tgt ccc agt cct gaa ttg gtg     4562
 Val Val Glu Ile Cys Pro Pro Ala Pro Cys Pro Ser Pro Glu Leu Val
            1505                1510                1515

 aaa gga acc tgc tgt cca gtt tgc aga gac cga gga atg cca agt gat     4610
 Lys Gly Thr Cys Cys Pro Val Cys Arg Asp Arg Gly Met Pro Ser Asp
        1520                1525                1530

 tcc cca gag aag cgc taa taaaag ttttgtgctg ttgagcccca aatgggaaat     4664
 Ser Pro Glu Lys Arg 
    1535

 ttctcaggaa gagacattta ggacttcaga acttttaact tgtagtcaca ttgttgatat   4724

 ggaaaccact gacttaagca acttagttca tctaatctta catatactta cgatctttta   4784

 ttttttcatt ttctaacata ccttgaaata attcaaaact aaaagcaata aagtgcatat   4844

 gaagtgtttg atcataagaa at                                            4866




      <210> 226
      <211> 4543
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(4305)

      <400> 226
 gagtccagca gccaccatca ccaccactgc ggttgctgct gcagctgcag ctgctgctct     60

 ccctccggct gcttcttcgc gtggccagca gcgaatggag cg   atg gag ccc aga     114
                                                  Met Glu Pro Arg
                                                    1

 ctg ttc tgc tgg acc act ctc ttt ctc ctg gcc ggg tgg tgc ctg cca      162
 Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly Trp Cys Leu Pro
   5                  10                  15                  20

 ggg ttg ccc tgc ccc agc cgg tgc ctt tgc ttt aag agc acc gtc cgc      210
 Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe Lys Ser Thr Val Arg
                  25                  30                  35

 tgc atg cac ttg atg ctg gac cac att cct cag gta cca cag cag acc      258
 Cys Met His Leu Met Leu Asp His Ile Pro Gln Val Pro Gln Gln Thr
              40                  45                  50

 aca gtt cta gac ttg agg ttt aac aga ata aga gaa att cca ggg agc      306
 Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile Pro Gly Ser
          55                  60                  65

 gcc ttc aag aaa ctc aag aat ttg aac aca ctt ctg ctg aac aac aac      354
 Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu Leu Leu Asn Asn Asn
      70                  75                  80

 cac atc aga aag att tcc aga aat gct ttt gaa gga ctt gaa aat ttg      402
 His Ile Arg Lys Ile Ser Arg Asn Ala Phe Glu Gly Leu Glu Asn Leu
  85                  90                  95                 100

 cta tat ctg tac ctg tat aag aat gaa atc cat gca cta gat aag caa      450
 Leu Tyr Leu Tyr Leu Tyr Lys Asn Glu Ile His Ala Leu Asp Lys Gln
                 105                 110                 115

 aca ttt aaa gga ctc ata tct ttg gaa cat ctg tat att cat ttc aac      498
 Thr Phe Lys Gly Leu Ile Ser Leu Glu His Leu Tyr Ile His Phe Asn
             120                 125                 130

 caa cta gaa atg cta cag cca gag acc ttt gga gac ctt ctg aga tta      546
 Gln Leu Glu Met Leu Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu
         135                 140                 145

 gag cga ctg gat gaa gcc cac ttg atc atg gtg gat aag ctt ttt gat      594
 Glu Arg Leu Asp Glu Ala His Leu Ile Met Val Asp Lys Leu Phe Asp
     150                 155                 160

 gtg ctg ctg gat tcg gtt tgc cag tat ttt att gag gat ttt tgc atc      642
 Val Leu Leu Asp Ser Val Cys Gln Tyr Phe Ile Glu Asp Phe Cys Ile
 165                 170                 175                 180

 gat gtt cat cag gag agc ccc cga att act ttt gag ccg cag gat gtg      690
 Asp Val His Gln Glu Ser Pro Arg Ile Thr Phe Glu Pro Gln Asp Val
                 185                 190                 195

 gag gta cca tca gga aat acc gtc tac ttc acc tgc cgg gcg gaa gga      738
 Glu Val Pro Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly
             200                 205                 210

 aac ccc aaa cct gag att att tgg ata cac aac aac cac tca ttg gat      786
 Asn Pro Lys Pro Glu Ile Ile Trp Ile His Asn Asn His Ser Leu Asp
         215                 220                 225

 ttg gaa gat gat act cga ctt aat gtg ttt gat gat ggc aca ctc atg      834
 Leu Glu Asp Asp Thr Arg Leu Asn Val Phe Asp Asp Gly Thr Leu Met
     230                 235                 240

 atc cga aac acc aga gag tca gac caa ggt gtc tat cag tgc atg gcc      882
 Ile Arg Asn Thr Arg Glu Ser Asp Gln Gly Val Tyr Gln Cys Met Ala
 245                 250                 255                 260

 aga aat tcc gct ggg gaa gcc aag aca cag agt gcc atg ctc aga tac      930
 Arg Asn Ser Ala Gly Glu Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr
                 265                 270                 275

 tcc agt ctt cca gcc aaa cca agc ttt gta atc cag cct cag gac aca      978
 Ser Ser Leu Pro Ala Lys Pro Ser Phe Val Ile Gln Pro Gln Asp Thr
             280                 285                 290

 gag gtt tta att ggc acc agc aca act ttg gaa tgt atg gcc aca ggc     1026
 Glu Val Leu Ile Gly Thr Ser Thr Thr Leu Glu Cys Met Ala Thr Gly
         295                 300                 305

 cac cca cac cct ctt atc act tgg acc agg gac aat gga ttg gag ctg     1074
 His Pro His Pro Leu Ile Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu
     310                 315                 320

 gat gga tcc agg cac gtg gca acg tcc agt gga ctt tac tta cag aac     1122
 Asp Gly Ser Arg His Val Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn
 325                 330                 335                 340

 atc aca caa cgg gat cat ggt cga ttt acc tgt cat gcc aac aat agc     1170
 Ile Thr Gln Arg Asp His Gly Arg Phe Thr Cys His Ala Asn Asn Ser
                 345                 350                 355

 cac ggc act gtt caa gct gca gca aac ata att gta caa gct cct cca     1218
 His Gly Thr Val Gln Ala Ala Ala Asn Ile Ile Val Gln Ala Pro Pro
             360                 365                 370

 caa ttt aca gta acc ccc aag gat caa gtg gtg ctg gaa gaa cat gct     1266
 Gln Phe Thr Val Thr Pro Lys Asp Gln Val Val Leu Glu Glu His Ala
         375                 380                 385

 gta gag tgg ctc tgt gaa gct gac ggc aac cca cct cct gtt att gtc     1314
 Val Glu Trp Leu Cys Glu Ala Asp Gly Asn Pro Pro Pro Val Ile Val
     390                 395                 400

 tgg aca aaa aca ggt att aga aca tct gca gga ggg cag ctc cct gtg     1362
 Trp Thr Lys Thr Gly Ile Arg Thr Ser Ala Gly Gly Gln Leu Pro Val
 405                 410                 415                 420

 gaa ggc cag cat aca gtt ctc tcc tct ggc act ttg aga att gac cgt     1410
 Glu Gly Gln His Thr Val Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg
                 425                 430                 435

 gca gca cag cac gat caa ggc caa tat gaa tgt caa gca gtc agt tcg     1458
 Ala Ala Gln His Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser
             440                 445                 450

 ttg ggg gtg aaa aag gtg tct gtg cag ctg act gta aaa ccc aaa ggt     1506
 Leu Gly Val Lys Lys Val Ser Val Gln Leu Thr Val Lys Pro Lys Gly
         455                 460                 465

 cca ttt atg caa atg aag gat tca aac ttg ctg agt tct gat tgg ttg     1554
 Pro Phe Met Gln Met Lys Asp Ser Asn Leu Leu Ser Ser Asp Trp Leu
     470                 475                 480

 gtt cag gta agc tct gaa ggt ctt gaa gtt aaa aag gaa ggt gtg cag     1602
 Val Gln Val Ser Ser Glu Gly Leu Glu Val Lys Lys Glu Gly Val Gln
 485                 490                 495                 500

 att act gag agt ggt aaa ttc cat gtg gat gat gaa ggc acg ctg act     1650
 Ile Thr Glu Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr
                 505                 510                 515

 atc tac gac gca ggg ttc cct gac cag gga aga tat gaa tgt gtg gct     1698
 Ile Tyr Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala
             520                 525                 530

 cgg aat tct ttt ggc ctt gct gtg acc aac atg ttt ctt aca gtc acg     1746
 Arg Asn Ser Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr
         535                 540                 545

 gtc tct gaa aaa aca gtg gag ctc tcc agg gca atg aat tgg ttt cca     1794
 Val Ser Glu Lys Thr Val Glu Leu Ser Arg Ala Met Asn Trp Phe Pro
     550                 555                 560

 tgt tta atg atg caa agt gat gaa aaa cct cac acc tcc agt gac ctg     1842
 Cys Leu Met Met Gln Ser Asp Glu Lys Pro His Thr Ser Ser Asp Leu
 565                 570                 575                 580

 ctg gct caa ttt cat tac ccg cgt gac cca ctg att gtg gaa atg gca     1890
 Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile Val Glu Met Ala
                 585                 590                 595

 aga gca ggg gag att ttt gag cac acg ctg cag ctg ata cgg gaa cgt     1938
 Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu Ile Arg Glu Arg
             600                 605                 610

 gtg aag cag ggg ctc act gtg gac ttg gaa ggc aaa gaa ttc cgg tac     1986
 Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr
         615                 620                 625

 aat gac ttg gtg tcc ccg cgc tcc ctc agc ctc atc gcc aat tta tct     2034
 Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser
     630                 635                 640

 gga tgc aca gct cgc agg cct ctg cca aac tgc tcc aac cgg tgt ttc     2082
 Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe
 645                 650                 655                 660

 cat gcg aag tac cgc gcc cac gac ggc acg tgc aac aac ctg cag cag     2130
 His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn Asn Leu Gln Gln
                 665                 670                 675

 ccc acg tgg ggc gcg gcg ctg acc gcc ttc gcg cgc ctg ctg cag cca     2178
 Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro
             680                 685                 690

 gcc tac cgg gac ggc atc cgc gcg ccc cgc ggg ctc ggc ctt cct gtg     2226
 Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro Val
         695                 700                 705

 ggc tcc cgc cag ccc ctc ccg ccg ccc cgg ctg gtc gcc aca gtg tgg     2274
 Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val Ala Thr Val Trp
     710                 715                 720

 gcg cgc gcg gcg gcc gtc acc ccc gac cac agc tac acg cgc atg ctc     2322
 Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr Thr Arg Met Leu
 725                 730                 735                 740

 atg cac tgg ggc tgg ttt cta gag cac gac ttg gac cac aca gtg cct     2370
 Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp His Thr Val Pro
                 745                 750                 755

 gcg ctg agc aca gcc cgc ttc tcg gat ggg cgg ccg tgc agc tcc gtc     2418
 Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser Val
             760                 765                 770

 tgc acc aac gac cct cct tgt ttc ccc atg aac acc cgg cac gcc gac     2466
 Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr Arg His Ala Asp
         775                 780                 785

 ccc cgg ggc acc cac gcg ccc tgc atg ctc ttc gcg cgc tcc agc ccc     2514
 Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala Arg Ser Ser Pro
     790                 795                 800

 gcg tgt gcc agc ggc cgt ccc tct gcg acg gtg gat tca gtc tat gca     2562
 Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp Ser Val Tyr Ala
 805                 810                 815                 820

 cga gag cag atc aac cag caa aca gcc tac atc gat ggc tcc aac gtt     2610
 Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val
                 825                 830                 835

 tac ggg agc tcg gag cgg gaa tcc cag gct ctc aga gac cct tcg gtg     2658
 Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser Val
             840                 845                 850

 cct cgg ggt ctc ctg aag aca ggc ttt cct tgg cct ccc tcc gga aag     2706
 Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys
         855                 860                 865

 ccc tta ttg ccc ttt tct aca ggc cca ccc acc gag tgc gcg cga cag     2754
 Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln
     870                 875                 880

 gag cag gag agc ccc tgt ttc ctg gcc ggg gac cac cgg gcc aac gag     2802
 Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His Arg Ala Asn Glu
 885                 890                 895                 900

 cat ctg gct ctg gcc gcc atg cac acc ctg tgg ttc cgg gaa cac aac     2850
 His Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe Arg Glu His Asn
                 905                 910                 915

 agg gtg gcc acg gag ctg tcc gcc ctg aac ccc cac tgg gag gga aac     2898
 Arg Val Ala Thr Glu Leu Ser Ala Leu Asn Pro His Trp Glu Gly Asn
             920                 925                 930

 acg gtt tac cag gaa gcc agg aag atc gtg ggc gcg gag ctg cag cac     2946
 Thr Val Tyr Gln Glu Ala Arg Lys Ile Val Gly Ala Glu Leu Gln His
         935                 940                 945

 atc acc tac agc cac tgg ctg cct aag gtc ctg ggg gac cct ggc act     2994
 Ile Thr Tyr Ser His Trp Leu Pro Lys Val Leu Gly Asp Pro Gly Thr
     950                 955                 960

 agg atg ctg agg ggt tac cga ggc tac aac ccc aac gtg aat gca ggc     3042
 Arg Met Leu Arg Gly Tyr Arg Gly Tyr Asn Pro Asn Val Asn Ala Gly
 965                 970                 975                 980

 atc att aac tct ttt gct act gca gcc ttt aga ttt ggc cac aca tta     3090
 Ile Ile Asn Ser Phe Ala Thr Ala Ala Phe Arg Phe Gly His Thr Leu
                 985                 990                 995

 atc aat cct att ctt tac cga ctg aat gcc acc tta ggt gaa att tcc     3138
 Ile Asn Pro Ile Leu Tyr Arg Leu Asn Ala Thr Leu Gly Glu Ile Ser
            1000                1005                1010

 gaa ggc cac ctt ccg ttc cat aaa gcg ctc ttt tca ccg tcc aga ata     3186
 Glu Gly His Leu Pro Phe His Lys Ala Leu Phe Ser Pro Ser Arg Ile
        1015                1020                1025

 atc aag gaa ggt ggg ata gac ccg gtt ctc cgg ggg ctg ttt ggc gtg     3234
 Ile Lys Glu Gly Gly Ile Asp Pro Val Leu Arg Gly Leu Phe Gly Val
    1030                1035                1040

 gct gct aaa tgg cgg gca ccc tcc tac ctt ctc agt cct gag ctg acc     3282
 Ala Ala Lys Trp Arg Ala Pro Ser Tyr Leu Leu Ser Pro Glu Leu Thr
1045                1050                1055                1060

 cag agg ctc ttc tcc gcg gct tat tct gcg gcc gtg gat tcg gct gcc     3330
 Gln Arg Leu Phe Ser Ala Ala Tyr Ser Ala Ala Val Asp Ser Ala Ala
                1065                1070                1075

 acc atc att caa agg ggt aga gac cac ggg atc cca cca tat gtt gac     3378
 Thr Ile Ile Gln Arg Gly Arg Asp His Gly Ile Pro Pro Tyr Val Asp
            1080                1085                1090

 ttc aga gtt ttc tgt aat ttg act tca gtt aag aac ttt gag gat ctt     3426
 Phe Arg Val Phe Cys Asn Leu Thr Ser Val Lys Asn Phe Glu Asp Leu
        1095                1100                1105

 caa aat gaa att aaa gat tca gag att aga caa aaa ctg aga aag ttg     3474
 Gln Asn Glu Ile Lys Asp Ser Glu Ile Arg Gln Lys Leu Arg Lys Leu
    1110                1115                1120

 tac ggc tct cca ggt gac att gac ctc tgg ccc gcc ctt atg gtt gaa     3522
 Tyr Gly Ser Pro Gly Asp Ile Asp Leu Trp Pro Ala Leu Met Val Glu
1125                1130                1135                1140

 gac ctg att cct ggt aca aga gtg gga cca aca ctt atg tgc ctg ttt     3570
 Asp Leu Ile Pro Gly Thr Arg Val Gly Pro Thr Leu Met Cys Leu Phe
                1145                1150                1155

 gtt acc cag ttt cag cgg cta aga gat gga gat agg ttc tgg tat gaa     3618
 Val Thr Gln Phe Gln Arg Leu Arg Asp Gly Asp Arg Phe Trp Tyr Glu
            1160                1165                1170

 aac cct gga gta ttt acc ccg gca caa ctc act cag ctg aag cag gcg     3666
 Asn Pro Gly Val Phe Thr Pro Ala Gln Leu Thr Gln Leu Lys Gln Ala
        1175                1180                1185

 tcc ctg agc cgg gtg ctt tgt gac aat ggt gac agc att cag caa gtg     3714
 Ser Leu Ser Arg Val Leu Cys Asp Asn Gly Asp Ser Ile Gln Gln Val
    1190                1195                1200

 cag gct gat gtc ttt gta aag gca gaa tac cca cag gat tac ctg aac     3762
 Gln Ala Asp Val Phe Val Lys Ala Glu Tyr Pro Gln Asp Tyr Leu Asn
1205                1210                1215                1220

 tgc agc gag atc ccg aag gtg gac ctg cga gtg tgg caa gac tgc tgt     3810
 Cys Ser Glu Ile Pro Lys Val Asp Leu Arg Val Trp Gln Asp Cys Cys
                1225                1230                1235

 gca gac tgt agg agt aga gga cag ttc aga gca gtg acg caa gag tct     3858
 Ala Asp Cys Arg Ser Arg Gly Gln Phe Arg Ala Val Thr Gln Glu Ser
            1240                1245                1250

 caa aag aaa cgc tca gct caa tac agc tat cct gtt gat aag gat atg     3906
 Gln Lys Lys Arg Ser Ala Gln Tyr Ser Tyr Pro Val Asp Lys Asp Met
        1255                1260                1265

 gag tta agt cat cta aga agt agg caa caa gat aaa ata tat gtg ggt     3954
 Glu Leu Ser His Leu Arg Ser Arg Gln Gln Asp Lys Ile Tyr Val Gly
    1270                1275                1280

 gaa gat gct aga aat gtg aca gtt ctg gca aaa aca aag ttc tcc caa     4002
 Glu Asp Ala Arg Asn Val Thr Val Leu Ala Lys Thr Lys Phe Ser Gln
1285                1290                1295                1300

 gat ttc agc acg ttt gca gcg gaa att cag gaa acc atc aca gca ctc     4050
 Asp Phe Ser Thr Phe Ala Ala Glu Ile Gln Glu Thr Ile Thr Ala Leu
                1305                1310                1315

 aga gag cag ata aac aag ctg gag gca cgc ctg agg cag gca ggg tgt     4098
 Arg Glu Gln Ile Asn Lys Leu Glu Ala Arg Leu Arg Gln Ala Gly Cys
            1320                1325                1330

 aca gat gtt aga ggg gtt cca agg aag gcc gag gag cgc tgg atg aaa     4146
 Thr Asp Val Arg Gly Val Pro Arg Lys Ala Glu Glu Arg Trp Met Lys
        1335                1340                1345

 gaa gac tgc act cac tgc att tgt gag agt ggc cag gtc acc tgt gtg     4194
 Glu Asp Cys Thr His Cys Ile Cys Glu Ser Gly Gln Val Thr Cys Val
    1350                1355                1360

 gtg gag att tgt ccc ccg gct ccc tgt ccc agt cct gaa ttg gtg aaa     4242
 Val Glu Ile Cys Pro Pro Ala Pro Cys Pro Ser Pro Glu Leu Val Lys
1365                1370                1375                1380

 gga acc tgc tgt cca gtt tgc aga gac cga gga atg cca agt gat tcc     4290
 Gly Thr Cys Cys Pro Val Cys Arg Asp Arg Gly Met Pro Ser Asp Ser
                1385                1390                1395

 cca gag aag cgc taa taaaagtttt gtgctgttga gccccaaatg ggaaatttct     4345
 Pro Glu Lys Arg 
            1400

 caggaagaga catttaggac ttcagaactt ttaacttgta gtcacattgt tgatatggaa   4405

 accactgact taagcaactt agttcatcta atcttacata tacttacgat cttttatttt   4465

 ttcattttct aacatacctt gaaataattc aaaactaaaa gcaataaagt gcatatgaag   4525

 tgtttgatca taagaaat                                                 4543




      <210> 227
      <211> 3252
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3252)

      <400> 227
  atg ccg ctg cac tcc agc ctg ggc aac aga cct ggt cat agt gaa gag      48
  Met Pro Leu His Ser Ser Leu Gly Asn Arg Pro Gly His Ser Glu Glu
    1               5                  10                  15

 gtg ctg ccc ggc aac ccc gtg aga cct gat gtc cgc gtg tgt gtg ccc       96
 Val Leu Pro Gly Asn Pro Val Arg Pro Asp Val Arg Val Cys Val Pro
              20                  25                  30

 cca ggc tac agc ggc gag ctg tgc gag gtg gac gag gac gag tgt gca      144
 Pro Gly Tyr Ser Gly Glu Leu Cys Glu Val Asp Glu Asp Glu Cys Ala
          35                  40                  45

 tcg agc ccc tgc cag cat ggg ggc cga tgc ctg cag cgc tct gac ccg      192
 Ser Ser Pro Cys Gln His Gly Gly Arg Cys Leu Gln Arg Ser Asp Pro
      50                  55                  60

 gcc ctc tac ggg ggt gtc cag gcc gcc ttc cct ggc gcc ttc agc ttc      240
 Ala Leu Tyr Gly Gly Val Gln Ala Ala Phe Pro Gly Ala Phe Ser Phe
  65                  70                  75                  80

 cgc cat gct gcg ggt ttc ctg tgc cac tgc cct cct ggc ttt gag gga      288
 Arg His Ala Ala Gly Phe Leu Cys His Cys Pro Pro Gly Phe Glu Gly
                  85                  90                  95

 gcc gac tgc ggt gtg gag gtg gac gag tgt gcc tca cgg cca tgc ctc      336
 Ala Asp Cys Gly Val Glu Val Asp Glu Cys Ala Ser Arg Pro Cys Leu
             100                 105                 110

 aac gga ggc cac tgc cag gac ctg ccc aat ggc ttc cag tgt cac tgc      384
 Asn Gly Gly His Cys Gln Asp Leu Pro Asn Gly Phe Gln Cys His Cys
         115                 120                 125

 cca gat ggc tac gca ggt gtc tgg ggt ggg gtg ggc cct ggg acc atc      432
 Pro Asp Gly Tyr Ala Gly Val Trp Gly Gly Val Gly Pro Gly Thr Ile
     130                 135                 140

 aga att ggt ggt cct cag aca tta ctg aac ctt ggc ttt gtc tct ccc      480
 Arg Ile Gly Gly Pro Gln Thr Leu Leu Asn Leu Gly Phe Val Ser Pro
 145                 150                 155                 160

 aaa ggg ccg aca tgt gag gaa gat gtg gat gaa tgc ctg tcg gat ccc      528
 Lys Gly Pro Thr Cys Glu Glu Asp Val Asp Glu Cys Leu Ser Asp Pro
                 165                 170                 175

 tgc ctg cac ggc gga acc tgc agt gac act gtg gca ggc tat atc tgc      576
 Cys Leu His Gly Gly Thr Cys Ser Asp Thr Val Ala Gly Tyr Ile Cys
             180                 185                 190

 agg tgc cca gag acc tgg ggt ggg cgc gac tgt tct gtg cag ctc act      624
 Arg Cys Pro Glu Thr Trp Gly Gly Arg Asp Cys Ser Val Gln Leu Thr
         195                 200                 205

 ggc tgc cag ggc cac acc tgc ccg ctg gct gcc acc tgc atc cct atc      672
 Gly Cys Gln Gly His Thr Cys Pro Leu Ala Ala Thr Cys Ile Pro Ile
     210                 215                 220

 ttc gag tct ggg gtc cac agt tac gtc tgc cac tgc cca cct ggt acc      720
 Phe Glu Ser Gly Val His Ser Tyr Val Cys His Cys Pro Pro Gly Thr
 225                 230                 235                 240

 cat gga ccg ttc tgt ggc cag aat acc acc ttc tct gtg atg gct ggg      768
 His Gly Pro Phe Cys Gly Gln Asn Thr Thr Phe Ser Val Met Ala Gly
                 245                 250                 255

 agc ccc att cag gca tca gtg cca gct ggt ggc ccc ctg ggt ctg gca      816
 Ser Pro Ile Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly Leu Ala
             260                 265                 270

 ctg agg ttt cgc acc aca ctg ccc gct ggg acc ttg gcc act cgc aat      864
 Leu Arg Phe Arg Thr Thr Leu Pro Ala Gly Thr Leu Ala Thr Arg Asn
         275                 280                 285

 gac acc aag gaa agc ttg gag ctg gca ttg gtg gca gcc aca ctt cag      912
 Asp Thr Lys Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Thr Leu Gln
     290                 295                 300

 gcc aca ctc tgg agc tac agc acc act gtg ctt gtc ctg aga ctg ccg      960
 Ala Thr Leu Trp Ser Tyr Ser Thr Thr Val Leu Val Leu Arg Leu Pro
 305                 310                 315                 320

 gac ctg gcc cta aac gat ggc cat tgg cac cag gtg gag gtt gtg ctc     1008
 Asp Leu Ala Leu Asn Asp Gly His Trp His Gln Val Glu Val Val Leu
                 325                 330                 335

 cat cta gcg acc ctg gag cta cgg ctc tgg cat gag ggc tgc cct gcc     1056
 His Leu Ala Thr Leu Glu Leu Arg Leu Trp His Glu Gly Cys Pro Ala
             340                 345                 350

 cgg ctc tgt gtg gcc tct ggt cct gtg gcc ctg gct tcc acg gct tcg     1104
 Arg Leu Cys Val Ala Ser Gly Pro Val Ala Leu Ala Ser Thr Ala Ser
         355                 360                 365

 gca act ccg ctg cct gcc ggg atc tcc tct gcc cag ctg ggg gac gcg     1152
 Ala Thr Pro Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly Asp Ala
     370                 375                 380

 acc ttt gca ggc tgc ctc cag gac gtg cgt gtg gat ggc cac ctc ctg     1200
 Thr Phe Ala Gly Cys Leu Gln Asp Val Arg Val Asp Gly His Leu Leu
 385                 390                 395                 400

 ctg cct gag gat ctc gag att cct gct gcc acc ttt ggc ttg gga ggc     1248
 Leu Pro Glu Asp Leu Glu Ile Pro Ala Ala Thr Phe Gly Leu Gly Gly
                 405                 410                 415

 gcc cca agc tct gcc tcc ttt ctg ctc caa gag ctg cca ggt ccc aac     1296
 Ala Pro Ser Ser Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro Asn
             420                 425                 430

 ctc aca gtg tct ttc ctt ctc cgc act cgg gag tcc gct ggc ctg ttg     1344
 Leu Thr Val Ser Phe Leu Leu Arg Thr Arg Glu Ser Ala Gly Leu Leu
         435                 440                 445

 ctc cag ttt gcc aat gac tcc gca gct ggc cta aca gta ttc ctg agt     1392
 Leu Gln Phe Ala Asn Asp Ser Ala Ala Gly Leu Thr Val Phe Leu Ser
     450                 455                 460

 gag ggt cgg atc cgg gct gag gcg ccg ggc agt cct gct gta gtg ctc     1440
 Glu Gly Arg Ile Arg Ala Glu Ala Pro Gly Ser Pro Ala Val Val Leu
 465                 470                 475                 480

 cct ggg cgc tgg gat gat ggg ctc cgt cac ctg gtg atg ctc agc ttc     1488
 Pro Gly Arg Trp Asp Asp Gly Leu Arg His Leu Val Met Leu Ser Phe
                 485                 490                 495

 ggg cct gac cag ctg cag gac ctg ggg cag cac gtg cac gtg ggt ggg     1536
 Gly Pro Asp Gln Leu Gln Asp Leu Gly Gln His Val His Val Gly Gly
             500                 505                 510

 agg ctc ctt gct gcc gac agc cag ccc tgg ggt ggg ccc ttc cga ggc     1584
 Arg Leu Leu Ala Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg Gly
         515                 520                 525

 tgc ctc cag gac ctg cga ctc gat ggc tgc cac ctc ccc ttc ttt cct     1632
 Cys Leu Gln Asp Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe Pro
     530                 535                 540

 ctg cca ctg gat aac tca agc cag ccc agc gag ctc ggc ggc agg cag     1680
 Leu Pro Leu Asp Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg Gln
 545                 550                 555                 560

 tcc tgg aac ctc act gcg ggc tgc gtc tcc gag gac atg tgc agt cct     1728
 Ser Trp Asn Leu Thr Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro
                 565                 570                 575

 gac ccc tgt ttc aat ggt ggg act tgc ctc gtc acc tgg aat gac ttc     1776
 Asp Pro Cys Phe Asn Gly Gly Thr Cys Leu Val Thr Trp Asn Asp Phe
             580                 585                 590

 cac tgt acc tgc cct gcc aat ttc acg ggg cct acg tgt gcc cag cag     1824
 His Cys Thr Cys Pro Ala Asn Phe Thr Gly Pro Thr Cys Ala Gln Gln
         595                 600                 605

 ctg tgg tgt ccc ggc cag ccc tgt ctc cca cct gcc acg tgt gag gag     1872
 Leu Trp Cys Pro Gly Gln Pro Cys Leu Pro Pro Ala Thr Cys Glu Glu
     610                 615                 620

 gtc cct gat ggc ttt gtg tgt gtg gcg gag gcc acg ttc cgc gag ggt     1920
 Val Pro Asp Gly Phe Val Cys Val Ala Glu Ala Thr Phe Arg Glu Gly
 625                 630                 635                 640

 ccc ccc gcc gcg ttc agc ggg cac aac gcg tcg tca ggg cgc ttg ctc     1968
 Pro Pro Ala Ala Phe Ser Gly His Asn Ala Ser Ser Gly Arg Leu Leu
                 645                 650                 655

 ggc ggc ctg tcg ctg gcc ttt cgc acg cgc gac tcc gag gcc tgg ctg     2016
 Gly Gly Leu Ser Leu Ala Phe Arg Thr Arg Asp Ser Glu Ala Trp Leu
             660                 665                 670

 ctg cgt gcc gcg gcg ggc gcc ctg gaa ggc gtg tgg ctg gcg gtg cgc     2064
 Leu Arg Ala Ala Ala Gly Ala Leu Glu Gly Val Trp Leu Ala Val Arg
         675                 680                 685

 aat ggc tcg ctg gcg ggg ggc gtg cgc gga ggc cat ggc ctg ccc ggc     2112
 Asn Gly Ser Leu Ala Gly Gly Val Arg Gly Gly His Gly Leu Pro Gly
     690                 695                 700

 gct gtg ctg ccc ata ccg ggg ccg cgc gtg gcc gat ggt gcc tgg cac     2160
 Ala Val Leu Pro Ile Pro Gly Pro Arg Val Ala Asp Gly Ala Trp His
 705                 710                 715                 720

 cgc gtg cgt ctg gcc atg gag cgc ccg gcg gcc gcc acc tcg cgc tgg     2208
 Arg Val Arg Leu Ala Met Glu Arg Pro Ala Ala Ala Thr Ser Arg Trp
                 725                 730                 735

 ctg ctg tgg ctg gat ggt gcc gcc acc ccg gtg gcg ctg cgc ggc ctg     2256
 Leu Leu Trp Leu Asp Gly Ala Ala Thr Pro Val Ala Leu Arg Gly Leu
             740                 745                 750

 gcc agt gac ctg ggc ttc ctg cag ggc ccg ggt gct gtg cgc atc ctg     2304
 Ala Ser Asp Leu Gly Phe Leu Gln Gly Pro Gly Ala Val Arg Ile Leu
         755                 760                 765

 ctg gct gag aac ttc acc ggc tgc ttg ggc cgc gtg gcg ctg ggc ggc     2352
 Leu Ala Glu Asn Phe Thr Gly Cys Leu Gly Arg Val Ala Leu Gly Gly
     770                 775                 780

 ctg ccc ctg ccc ttg gcg cgg ccc cgg ccc ggc gcg gcc cct ggc gcc     2400
 Leu Pro Leu Pro Leu Ala Arg Pro Arg Pro Gly Ala Ala Pro Gly Ala
 785                 790                 795                 800

 cga gag cac ttc gcc tct tgg cct ggg acg ccg gcc ccg atc ctc ggc     2448
 Arg Glu His Phe Ala Ser Trp Pro Gly Thr Pro Ala Pro Ile Leu Gly
                 805                 810                 815

 tgc cgc ggc gcg ccc gtg tgt gcg ccc tcg ccc tgt ctg cac gac ggt     2496
 Cys Arg Gly Ala Pro Val Cys Ala Pro Ser Pro Cys Leu His Asp Gly
             820                 825                 830

 gcc tgc cgt gac ctc ttc gac gcc ttt gcc tgc gcc tgc ggc ccg ggg     2544
 Ala Cys Arg Asp Leu Phe Asp Ala Phe Ala Cys Ala Cys Gly Pro Gly
         835                 840                 845

 tgg gaa ggc ccg cgc tgc gaa gcc cac gtc gac ccc tgt cac tcc gcc     2592
 Trp Glu Gly Pro Arg Cys Glu Ala His Val Asp Pro Cys His Ser Ala
     850                 855                 860

 ccc tgc gcc cgt ggc cgc tgt cac acg cac ccc gac ggc cgc ttc gag     2640
 Pro Cys Ala Arg Gly Arg Cys His Thr His Pro Asp Gly Arg Phe Glu
 865                 870                 875                 880

 tgc cgc tgc ccg cct ggc ttc ggg ggc ccg cgc tgc agg ttg cct gtc     2688
 Cys Arg Cys Pro Pro Gly Phe Gly Gly Pro Arg Cys Arg Leu Pro Val
                 885                 890                 895

 cca tcc aag gag tgc agc ctg aat gtc acc tgc ctc gat ggc agc cca     2736
 Pro Ser Lys Glu Cys Ser Leu Asn Val Thr Cys Leu Asp Gly Ser Pro
             900                 905                 910

 tgt gag ggt ggc tct ccc gct gcc aac tgc agc tgc ctg gag ggt ctt     2784
 Cys Glu Gly Gly Ser Pro Ala Ala Asn Cys Ser Cys Leu Glu Gly Leu
         915                 920                 925

 gct ggc cag agg tgt cag gtc ccc act ctc ccc tgt gaa gcc aac ccc     2832
 Ala Gly Gln Arg Cys Gln Val Pro Thr Leu Pro Cys Glu Ala Asn Pro
     930                 935                 940

 tgc ttg aat ggg ggc acc tgc cgg gca gct gga ggg gtg tct gaa tgt     2880
 Cys Leu Asn Gly Gly Thr Cys Arg Ala Ala Gly Gly Val Ser Glu Cys
 945                 950                 955                 960

 atc tgc aat gcc aga ttc tcc ggc cag ttc tgt gaa gtg gcg aag ggc     2928
 Ile Cys Asn Ala Arg Phe Ser Gly Gln Phe Cys Glu Val Ala Lys Gly
                 965                 970                 975

 ctg ccc ctg ccg ctg cca ttc cca ctg ctg gag gtg gcc gta cct gca     2976
 Leu Pro Leu Pro Leu Pro Phe Pro Leu Leu Glu Val Ala Val Pro Ala
             980                 985                 990

 gcc tgt gcc tgc ctc ctc ctc ctc ctc ctg ggc ctc ctt tca ggg atc     3024
 Ala Cys Ala Cys Leu Leu Leu Leu Leu Leu Gly Leu Leu Ser Gly Ile
         995                1000                1005

 ctg gca gcc cga aag cgc cgc cag tct gag ggc acc tac agc cca agc     3072
 Leu Ala Ala Arg Lys Arg Arg Gln Ser Glu Gly Thr Tyr Ser Pro Ser
    1010                1015                1020

 cag cag gag gtg gct ggg gcc cgg ctg gag atg gac agt gtc ctc aag     3120
 Gln Gln Glu Val Ala Gly Ala Arg Leu Glu Met Asp Ser Val Leu Lys
1025                1030                1035                1040

 ggc tgt tgt gag gat cag aga gga cga cag tgg gga aag aat ctg gaa     3168
 Gly Cys Cys Glu Asp Gln Arg Gly Arg Gln Trp Gly Lys Asn Leu Glu
                1045                1050                1055

 gtc ttc aac tgc cgt ctg atg gga agg acc gtc tgg gtg tcc ttc tgg     3216
 Val Phe Asn Cys Arg Leu Met Gly Arg Thr Val Trp Val Ser Phe Trp
            1060                1065                1070

 gat gag gat gac aga gca acc ctt ctc ctg ccc tga                     3252
 Asp Glu Asp Asp Arg Ala Thr Leu Leu Leu Pro 
        1075                1080





      <210> 228
      <211> 270
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(270)

      <400> 228
  atg aac atg gct tat ggc agc ctc cac ctc ctg ggc tca agc ggt cct      48
  Met Asn Met Ala Tyr Gly Ser Leu His Leu Leu Gly Ser Ser Gly Pro
    1               5                  10                  15

 ccc acc tca gcc tcc cga gta gct agg acc aca ggc atg agc cac cat       96
 Pro Thr Ser Ala Ser Arg Val Ala Arg Thr Thr Gly Met Ser His His
              20                  25                  30

 gtc cgg cta att ttt aaa aaa tat ttt ttt gta gag acg agg tct cac      144
 Val Arg Leu Ile Phe Lys Lys Tyr Phe Phe Val Glu Thr Arg Ser His
          35                  40                  45

 tat gtt gct cag acc agt ctt gaa ttc ctg gac tca agc aat cct ccc      192
 Tyr Val Ala Gln Thr Ser Leu Glu Phe Leu Asp Ser Ser Asn Pro Pro
      50                  55                  60

 acc tca gcc tcc caa aat gct ggg att tat agg tat gag cca ctg tgc      240
 Thr Ser Ala Ser Gln Asn Ala Gly Ile Tyr Arg Tyr Glu Pro Leu Cys
  65                  70                  75                  80

 cca gcc aat gca aac att ttc att agt taa                              270
 Pro Ala Asn Ala Asn Ile Phe Ile Ser 
                  85





      <210> 229
      <211> 4505
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(1901)

      <400> 229
 agaaa    atg ttg cca gtt gat ggg gaa gaa agg aag tcg gag ggc tca      47
          Met Leu Pro Val Asp Gly Glu Glu Arg Lys Ser Glu Gly Ser
            1               5                  10

 gac act gag ggg gac aga aca tct cca tgt gca gtc tca tct gct acc       95
 Asp Thr Glu Gly Asp Arg Thr Ser Pro Cys Ala Val Ser Ser Ala Thr
  15                  20                  25                  30

 ctg aag gat ctg gag gta gga ggc tct ggg cgg agg tgc agt gac ccc      143
 Leu Lys Asp Leu Glu Val Gly Gly Ser Gly Arg Arg Cys Ser Asp Pro
                  35                  40                  45

 gca ggc cag ccc tcc aac ctc ctc ccg cag cgg gga ctg ggt gcc cct      191
 Ala Gly Gln Pro Ser Asn Leu Leu Pro Gln Arg Gly Leu Gly Ala Pro
              50                  55                  60

 ctg cca gct gag aca gcc cac aca caa ccc agc cct aat gat cgt tct      239
 Leu Pro Ala Glu Thr Ala His Thr Gln Pro Ser Pro Asn Asp Arg Ser
          65                  70                  75

 ctc tac ctc tcc ccc aag tcc tcc tcc gcc tcc tcc tct ctg cat gcg      287
 Leu Tyr Leu Ser Pro Lys Ser Ser Ser Ala Ser Ser Ser Leu His Ala
      80                  85                  90

 cgt cag agc ccg tgc caa gaa caa gca gca gtc ctg aac tcg agg tcc      335
 Arg Gln Ser Pro Cys Gln Glu Gln Ala Ala Val Leu Asn Ser Arg Ser
  95                 100                 105                 110

 ata aaa atc agt cga ctg aat gac acc atc aaa tct ttg aaa caa cag      383
 Ile Lys Ile Ser Arg Leu Asn Asp Thr Ile Lys Ser Leu Lys Gln Gln
                 115                 120                 125

 aag aaa caa gtg gaa cat cag ctg gaa gaa gaa aag aaa gca aac aat      431
 Lys Lys Gln Val Glu His Gln Leu Glu Glu Glu Lys Lys Ala Asn Asn
             130                 135                 140

 gag aaa cag aaa gct gaa agg gag cta gag ggt caa atc cag aga ttg      479
 Glu Lys Gln Lys Ala Glu Arg Glu Leu Glu Gly Gln Ile Gln Arg Leu
         145                 150                 155

 aac aca gag aaa aag aaa cta aat acg gac ctg tat cac atg aaa cat      527
 Asn Thr Glu Lys Lys Lys Leu Asn Thr Asp Leu Tyr His Met Lys His
     160                 165                 170

 tct ctc aga tac ttt gaa gaa gag tcc aag gat ctg gcc ggc cgc ctg      575
 Ser Leu Arg Tyr Phe Glu Glu Glu Ser Lys Asp Leu Ala Gly Arg Leu
 175                 180                 185                 190

 caa cgt tca tcg cag cgt ata gga gag tta gag tgg tct ctc tgt gct      623
 Gln Arg Ser Ser Gln Arg Ile Gly Glu Leu Glu Trp Ser Leu Cys Ala
                 195                 200                 205

 gtc gcc gcc aca cag aag aag aag ccg gat ggg ttc tcg agc cgc agt      671
 Val Ala Ala Thr Gln Lys Lys Lys Pro Asp Gly Phe Ser Ser Arg Ser
             210                 215                 220

 aaa gca ctt ctc aag cgg cag tta gag cag tcc ata cgg gag cag ata      719
 Lys Ala Leu Leu Lys Arg Gln Leu Glu Gln Ser Ile Arg Glu Gln Ile
         225                 230                 235

 ctg ctg aaa gga cac gtg aca cag ttg aag gag tcg ctt aaa gaa gtc      767
 Leu Leu Lys Gly His Val Thr Gln Leu Lys Glu Ser Leu Lys Glu Val
     240                 245                 250

 cag ctg gag aga gat caa tat gct gaa caa ata aaa gga gag agg gcc      815
 Gln Leu Glu Arg Asp Gln Tyr Ala Glu Gln Ile Lys Gly Glu Arg Ala
 255                 260                 265                 270

 cag tgg cag cag agg atg agg aaa atg tcg cag gag gtt tgc aca ttg      863
 Gln Trp Gln Gln Arg Met Arg Lys Met Ser Gln Glu Val Cys Thr Leu
                 275                 280                 285

 aag gag gag aag aag cat gat acg cat cgg gta gag gag ctg gag agg      911
 Lys Glu Glu Lys Lys His Asp Thr His Arg Val Glu Glu Leu Glu Arg
             290                 295                 300

 agc ttg tcc aga ctc aaa aac cag atg gct gag cca ctg ccc ccg gat      959
 Ser Leu Ser Arg Leu Lys Asn Gln Met Ala Glu Pro Leu Pro Pro Asp
         305                 310                 315

 gcc cca gca gtg tcc tct gag gtg gag ctg caa gac ctg agg aag gag     1007
 Ala Pro Ala Val Ser Ser Glu Val Glu Leu Gln Asp Leu Arg Lys Glu
     320                 325                 330

 ctg gag aga gtg gca gga gag ctc cag gct cag gtg gaa aac aat cag     1055
 Leu Glu Arg Val Ala Gly Glu Leu Gln Ala Gln Val Glu Asn Asn Gln
 335                 340                 345                 350

 tgc atc agt ctc ctg aac cgt ggg caa aag gag agg ctt cgc gag cag     1103
 Cys Ile Ser Leu Leu Asn Arg Gly Gln Lys Glu Arg Leu Arg Glu Gln
                 355                 360                 365

 gag gag agg ctt cag gag cag cag gag agg ctt cgg gaa cag gag aag     1151
 Glu Glu Arg Leu Gln Glu Gln Gln Glu Arg Leu Arg Glu Gln Glu Lys
             370                 375                 380

 agg ctt cag cag ctg gcc gag cca cag agc gac ttg gag gag ctg aag     1199
 Arg Leu Gln Gln Leu Ala Glu Pro Gln Ser Asp Leu Glu Glu Leu Lys
         385                 390                 395

 cac gag aac aag agc gca ctg cag ttg gag cag caa gta aag gag ctg     1247
 His Glu Asn Lys Ser Ala Leu Gln Leu Glu Gln Gln Val Lys Glu Leu
     400                 405                 410

 cag gag aag ctg ggc cag gtg atg gag acg ctc acc tcg gcc gag aag     1295
 Gln Glu Lys Leu Gly Gln Val Met Glu Thr Leu Thr Ser Ala Glu Lys
 415                 420                 425                 430

 gag cca gag gca gca gtc cca gcc tca ggg act ggg ggc gag tct agc     1343
 Glu Pro Glu Ala Ala Val Pro Ala Ser Gly Thr Gly Gly Glu Ser Ser
                 435                 440                 445

 ggc ctt atg gac ctc ctg gag gag aag gcg gac ctg agg gag cat gtg     1391
 Gly Leu Met Asp Leu Leu Glu Glu Lys Ala Asp Leu Arg Glu His Val
             450                 455                 460

 gag aaa ctg gaa ctt gga ttc atc cag tac cgg aga gag aga tgc cat     1439
 Glu Lys Leu Glu Leu Gly Phe Ile Gln Tyr Arg Arg Glu Arg Cys His
         465                 470                 475

 cag aac gta cat cgc ctt cta aca gag cca ggg gac agt gcc aaa gat     1487
 Gln Asn Val His Arg Leu Leu Thr Glu Pro Gly Asp Ser Ala Lys Asp
     480                 485                 490

 gcg tca ccg gga gga ggc cat cat cag gct ggc cca gga caa gga gga     1535
 Ala Ser Pro Gly Gly Gly His His Gln Ala Gly Pro Gly Gln Gly Gly
 495                 500                 505                 510

 gag gaa ggt gaa gct gct gga gct gca gga gat ggt gtt gcg gct tgt     1583
 Glu Glu Gly Glu Ala Ala Gly Ala Ala Gly Asp Gly Val Ala Ala Cys
                 515                 520                 525

 ggc agc tac aac gag ggg cac ggc aaa ttc ctg gcc gct gcc cgg aac     1631
 Gly Ser Tyr Asn Glu Gly His Gly Lys Phe Leu Ala Ala Ala Arg Asn
             530                 535                 540

 cct gct gct gaa ccc agt cca gga gcc cca gcc ccc cag gag ctc ggg     1679
 Pro Ala Ala Glu Pro Ser Pro Gly Ala Pro Ala Pro Gln Glu Leu Gly
         545                 550                 555

 gct gcc gac aag cat ggt gat ctt tgt gag gcg agc ctc acc aac agc     1727
 Ala Ala Asp Lys His Gly Asp Leu Cys Glu Ala Ser Leu Thr Asn Ser
     560                 565                 570

 gtg gag cct gca caa gga gaa gcc agg gag ggt tct tcc cag gac aac     1775
 Val Glu Pro Ala Gln Gly Glu Ala Arg Glu Gly Ser Ser Gln Asp Asn
 575                 580                 585                 590

 cct act gca cag cca gtc gtg cag ctc ctt ggt gag atg cag gac cac     1823
 Pro Thr Ala Gln Pro Val Val Gln Leu Leu Gly Glu Met Gln Asp His
                 595                 600                 605

 cag gag cac cca ggc ttg ggc agc aac tgc tgt gtg cca tgc ttt tgc     1871
 Gln Glu His Pro Gly Leu Gly Ser Asn Cys Cys Val Pro Cys Phe Cys
             610                 615                 620

 tgg gct tgg ctg ccg aga aga agg aga taa a caccaccatc atcaaagagc     1922
 Trp Ala Trp Leu Pro Arg Arg Arg Arg 
         625                 630

 tgctcaagaa atttttaaaa acgaaacaaa gttatggggt taatctccta cacaattcat   1982

 ttacttcatt tgaatgttag agctactcat gattatttgt gtttctaatt tatagtttaa   2042

 gtttatttgt aaaaagttaa aagagagtgg gtctctgtgg ctctcactga tgttcactct   2102

 ggcatccttc agcatttttc ttttttcatt tcataattgt aggtcattag catgcatatc   2162

 gagtttgccc ttacgtggtg ggagttcaaa cacacaaaga cccactcttt gcacaaaact   2222

 gttctcgctg gtttggaata ggctcccgtg cttttctaat gttattgcag catggatgtc   2282

 cattacagaa ttcagataaa atttgctaat gttctgctat gatgtttgat ctcatcttaa   2342

 tcacagtgag ctcttctata gctcaatatg cggtttgccc tcaagtgtgc actgtttatt   2402

 actttgtaat atgccactgt gagtactgac atttagagct gtttaaaggc caagaactgg   2462

 aaacagcctt tcctccattt tctgtgtatt ggtgatggga gtgataacct tttgggggag   2522

 ctttctaaat ctcacagaag aggaaagtgg cctgctctgg caggtatgtg caggatacag   2582

 tgtgtttcat ctgttccggt gccaagaatg agcagtgtac tgtggcagtt ccctttggat   2642

 ttgtatgtgc tctgggctca tgaagatatt gcatcgtgag ctgcagcagt tgcactcttt   2702

 ttcaatgacc taaaaagggc ttatttccga ggaatgaaag gctgccatca ttggctgtgg   2762

 gtgtgaaaaa cctttcctag cttagagcat ttgtatctac aatacatttt aaagtcagag   2822

 ttcgtgttcc ctgttttaat cacatgacta cctgtcccag tacacgaaag ggcgctggtt   2882

 ggcattcttc ttaatgtatt tagtgaagat cataagaaat cctttaagag tttaaatgtc   2942

 tctgaaacag gcatacaggc tctagtcaag aatgaattag agtgaaggaa agctgtgtga   3002

 cacctggcat tcctctctgt tcatggagct tctttgaggc ttgaagtttg attttactat   3062

 ctagacctct ctggctaata cctattcttc aaccacctcg gttactctga cataggaatt   3122

 tacttctttt ccttgagtgg aaaacacttt agaaagtaat aacaaacatt attataaact   3182

 aatatatgtg agagtactta gttgaaacaa aaaggaattt tagtagacag tattatatta   3242

 tctttgaaaa tcaaggagaa gtttatgcaa cttaaaatgt ttacacactg tggtgcaatc   3302

 tactgtttgt gaatgtctgt attatcagga aacatgtcta tacgatcgca gagttgtatt   3362

 tcctcacaaa cttctttacg aagagtgaaa tacgtttttg tacctctcat tttcagtcag   3422

 ggacatactt tgtgcaatat ttctgtgatt gtgcctatgc atgatgaatg aatgcatttc   3482

 aatcatacat tgcctaaatc ataacttgat gatgcttggg aaagaatcaa cagttaaaac   3542

 ttcatgaagt tctaatgtct gtgttccaaa acacatcaca ttattaggtt gtagggagat   3602

 atgtaggtgt gctccctggg gtggggagtt ttctagttac tagaccatct ccatttttag   3662

 cacttggcag cctcatgatc cttttataaa tgtgagatta acaggagagc agcaatacga   3722

 ttttgccaat ggaataacag atttgccggc attcactgaa agagggcaga tattgggtcc   3782

 ttgtaacttc aactgactct tccaaattgt atgaatttat caatgtatta cacaaatcca   3842

 gtttcagaat gataaaaaat gttagaccaa ataatgcggc taattaacag tcgtatgatt   3902

 tctagcccat gggtttaaaa ctgtatccta aagagtcatt ttaaaataat ataaatatta   3962

 aaaaatgtaa ctgctatctt aatgttctga aataaaacat tttaaaatat aaatcctgta   4022

 gtttaaaagg aagaaatggt gggaaggaaa agtagagaaa gaaatgccaa ttacaggcca   4082

 aagcgttatt tgccaagttt tcttagaatg aattttacca atgtatgagt tcttgttaac   4142

 agaatgtgta acggaaatac tgaaagactt ttgcttaaag tggcattatt gactgctgat   4202

 gtgatgctac tgtaatgcaa taaattttta aattgttgca aaaaaaaaaa aaaagggggg   4262

 cccttttaaa agaacccttg gggggcccaa atttaacggg ggatggaaac gtaaaatttt   4322

 ttttttttag ggggggctta ataaaaccct ccttgggaat ttttggaaaa aaaccttttt   4382

 tttggggggg gaaaaaattg gcccaacctc cctacaaaat ttaaagcctt aagggaaaaa   4442

 aaaaattttt aaggggaaaa gggggaaaaa caaccccaat accctcgctg ttaaaaaaat   4502

 ggg                                                                 4505




      <210> 230
      <211> 2492
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(1248)

      <400> 230
 ggcacgaggc gctcgccagc cgtccccgcg ccccgcgtcc ccgcgcagcc gcctcctggc     60

 ctcgggcgcc gcgcatccag gaaggaagca gccaccctcg cc   atg gcc tcc ccg     114
                                                  Met Ala Ser Pro
                                                    1

 ccc gcc tgc ccc tcg gag gag gac gag agc ctg aag ggc tgt gag ctg      162
 Pro Ala Cys Pro Ser Glu Glu Asp Glu Ser Leu Lys Gly Cys Glu Leu
   5                  10                  15                  20

 tac gtg cag ctg cac ggg atc cag cag gtc ctc aaa gac tgt atc gtc      210
 Tyr Val Gln Leu His Gly Ile Gln Gln Val Leu Lys Asp Cys Ile Val
                  25                  30                  35

 cac ctc tgc atc tcc aag ccc gaa cgc ccc atg aag ttc ctc cgg gag      258
 His Leu Cys Ile Ser Lys Pro Glu Arg Pro Met Lys Phe Leu Arg Glu
              40                  45                  50

 cac ttc gag aag ctg gag aag gaa gaa aac agg cag att ttg gcg cgg      306
 His Phe Glu Lys Leu Glu Lys Glu Glu Asn Arg Gln Ile Leu Ala Arg
          55                  60                  65

 caa aag tca aac tca cag tcg gac tcc cat gat gag gag gtg tcg ccc      354
 Gln Lys Ser Asn Ser Gln Ser Asp Ser His Asp Glu Glu Val Ser Pro
      70                  75                  80

 acc ccc ccg aac cct gtg gtg aag gcc cgc cgc cgg cga gga ggc gtg      402
 Thr Pro Pro Asn Pro Val Val Lys Ala Arg Arg Arg Arg Gly Gly Val
  85                  90                  95                 100

 agt gcc gag gtg tac acc gag gag gac gcc gtg tcc tac gtc agg aag      450
 Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Val Ser Tyr Val Arg Lys
                 105                 110                 115

 gtg att ccc aag gac tac aaa acc atg act gcg ctg gcc aag gcc atc      498
 Val Ile Pro Lys Asp Tyr Lys Thr Met Thr Ala Leu Ala Lys Ala Ile
             120                 125                 130

 tcc aag aac gtg ctc ttc gct cac ctg gat gac aac gag agg agt gac      546
 Ser Lys Asn Val Leu Phe Ala His Leu Asp Asp Asn Glu Arg Ser Asp
         135                 140                 145

 ata ttc gat gcc atg ttc cct gtc act cac atc gct ggg gag act gtt      594
 Ile Phe Asp Ala Met Phe Pro Val Thr His Ile Ala Gly Glu Thr Val
     150                 155                 160

 ata cag caa ggg aat gaa gga gac aac ttc tat gtc gtt gat caa ggg      642
 Ile Gln Gln Gly Asn Glu Gly Asp Asn Phe Tyr Val Val Asp Gln Gly
 165                 170                 175                 180

 gaa gtg gat gtg tac gtg aac gga gag tgg gtg acc aac atc agc gag      690
 Glu Val Asp Val Tyr Val Asn Gly Glu Trp Val Thr Asn Ile Ser Glu
                 185                 190                 195

 gga ggc agc ttc ggg gag ctg gcg ctc atc tac ggc acc ccc agg gct      738
 Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly Thr Pro Arg Ala
             200                 205                 210

 gcg acc gtg aaa gcc aag acg gac ctc aag ctc tgg ggg atc gac cgg      786
 Ala Thr Val Lys Ala Lys Thr Asp Leu Lys Leu Trp Gly Ile Asp Arg
         215                 220                 225

 gac agc tac cgg cgc atc ctt atg ggc agc acg ctg agg aaa cgc aag      834
 Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu Arg Lys Arg Lys
     230                 235                 240

 atg tac gag gag ttc ctc agc aag gtc tcc atc cta gag tcc ctg gag      882
 Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu Glu Ser Leu Glu
 245                 250                 255                 260

 aag tgg gag cgt ctg acc gtg gcg gat gcg ctg gag ccc gtc cag ttt      930
 Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu Pro Val Gln Phe
                 265                 270                 275

 gaa gat gga gag aaa att gtg gtc cag gga gag cct ggg gac gac ttt      978
 Glu Asp Gly Glu Lys Ile Val Val Gln Gly Glu Pro Gly Asp Asp Phe
             280                 285                 290

 tac atc atc acg gag ggc acc gcg tcc gtg ctg cag cgc cgg tcc ccc     1026
 Tyr Ile Ile Thr Glu Gly Thr Ala Ser Val Leu Gln Arg Arg Ser Pro
         295                 300                 305

 aat gag gag tac gtg gag gtg ggg cgc ctg gga ccc tct gac tac ttc     1074
 Asn Glu Glu Tyr Val Glu Val Gly Arg Leu Gly Pro Ser Asp Tyr Phe
     310                 315                 320

 ggg gag att gca ctg ctg ctg aac cgg ccc cgg gcg gcc act gtc gtg     1122
 Gly Glu Ile Ala Leu Leu Leu Asn Arg Pro Arg Ala Ala Thr Val Val
 325                 330                 335                 340

 gcc cgg ggg ccc ctc aag tgt gtg aag ctg gac cgg ccc cgc ttc gag     1170
 Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg Pro Arg Phe Glu
                 345                 350                 355

 cgt gtg ctg ggg ccc tgc tct gag atc ctc aag agg aac att cag cgt     1218
 Arg Val Leu Gly Pro Cys Ser Glu Ile Leu Lys Arg Asn Ile Gln Arg
             360                 365                 370

 tac aac agc ttc atc tcc ctc acc gtc tga g cacagctccc gccctgcagc     1269
 Tyr Asn Ser Phe Ile Ser Leu Thr Val 
         375                 380

 cccagctccc cagtgtggtg gccgtgccct gctcgtctgt gtcgggggcc cgggagccgc   1329

 tgtgtgaggt gtgggccggg tggggctggg tcccggcagc gtgaggactg ccccttcccc   1389

 ggactcactt tttggaataa atgatcacct tgtgcatttc caaatcaaag gacaagcgga   1449

 caaaatgcat cccaagatca aggaagggac aggccagctt cctccccaca cgcctccccg   1509

 gctgcctctg tgggcttctg ctggggggcc caccccaccc ctgccagtct cctgggagat   1569

 gcttgaggat cggtcctccc cagaaccagg ccagggacgt tgcccctggg gcctggtgac   1629

 cctgtgaggt caggtccccc agattgaggt ctgagtgtgg gcaagtgtgt caaaaggggc   1689

 tgcccccagg ggagatgagg ctgagagcag ggagttgagg ccgaagaagt caaggcccct   1749

 cccgcaaatg tgtacccctg cccgcgccac tgcaccccgc cgcaccccca cctccccggg   1809

 ggccctgctg cggatcgcgg agtgggagag tctctgagct atgagattga tcttgcccct   1869

 aattggagag gaagccgggc gccaagacac acggggctcc tgccttggga gccagggccg   1929

 cggccgcagg tagaccccag tagggggggc cgggctcgaa gttcctttgg gaggggctgg   1989

 cgggactcca gcaggccgtc ctcacctttc ttagaaagtc cacccagggc aagttgatgt   2049

 tgggggaaag cagaagtcaa gccagccgcg ggccccacac gccccgaccc gctcaaccga   2109

 cttgtccctt aaatgtgtct tggatcccgc agtgatgacg tgagccagcc aggcccgaaa   2169

 gggtgaggcc agtgcagaga agcttcccag gggattcctg ggttcccccg aaagacaagc   2229

 gaggtcattg cagttcaccc gatgttgctc ctgtcccgtg cgtcccgggg aggctgtcct   2289

 tggtccgagg ctgctcgttg cagcccctcc cctgctggcg gttacgatgc gtggggtccc   2349

 cctccccacc cagccccggc cacgtcgccg tgtcccgcct gtgcctgtga cgtccctgtg   2409

 gacctgtgag ccatcccccc cccttatctc tgctctgaat actgcatgaa gcattaaacg   2469

 tgcaatgaag tacaaaaaaa aaa                                           2492




      <210> 231
      <211> 2669
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (420)..(2384)

      <400> 231
 gcaagcccag catcagcctc tcagcccccg acatcctgcc tctacactgc accatccgcc     60

 ggcaaccgct cccggacagc ggccaggccg cggggaggct ggtcctggag cccatccccg    120

 gggcgcacat ctccgtcaac ttctccgagg tggggcacag gaccgtggtg ctgcaccacg    180

 gggacctgct ctccctgggg ctctactacc tgctgctatt caaggacccc gcgcaggccc    240

 agcccctgcc cgcccgggcc ttggcgcgcc tccgggctgt gccgcagagc tgccggctgt    300

 gcggggccgc gctcggggcc cggggagccg cctcccctac tcaggccgcc ctgccccggc    360

 gccagcagct gctcctggag tttgagcccc acctggagga cacgctgctg cagaggatc     419                                                                 
 atg acg ttg atc gag ccg ggg ggc gac gac cac aag ctg acc ccc gcc      467
 Met Thr Leu Ile Glu Pro Gly Gly Asp Asp His Lys Leu Thr Pro Ala
   1               5                  10                  15

 ttc ctc ctg tgc ctc tgc atc cag cac tcg gcc acc cac ttc cag ccg      515
 Phe Leu Leu Cys Leu Cys Ile Gln His Ser Ala Thr His Phe Gln Pro
              20                  25                  30

 ggc aca ttc ggg cag ctc ctg ctc aag ata gcc agg ctg atc cgc gag      563
 Gly Thr Phe Gly Gln Leu Leu Leu Lys Ile Ala Arg Leu Ile Arg Glu
          35                  40                  45

 act gtc tgg gag aaa acc aaa gaa cta gca gag aag cag gcg caa ctc      611
 Thr Val Trp Glu Lys Thr Lys Glu Leu Ala Glu Lys Gln Ala Gln Leu
      50                  55                  60

 cag gag ccc atc tcg ctg gcc agc tgc gcc atg gct gat ctg gtt cca      659
 Gln Glu Pro Ile Ser Leu Ala Ser Cys Ala Met Ala Asp Leu Val Pro
  65                  70                  75                  80

 gac ttg cag ccc att ctt ttc tgg atg tct aac tcc atc gag ctc ctg      707
 Asp Leu Gln Pro Ile Leu Phe Trp Met Ser Asn Ser Ile Glu Leu Leu
                  85                  90                  95

 tac ttt atc cag cag aaa tgc cca ctc tac atg cag agc atg gag gag      755
 Tyr Phe Ile Gln Gln Lys Cys Pro Leu Tyr Met Gln Ser Met Glu Glu
             100                 105                 110

 cag ctg gac atc aca ggc tcg aag gaa tcg ctg ttc tcc tgc acg ctg      803
 Gln Leu Asp Ile Thr Gly Ser Lys Glu Ser Leu Phe Ser Cys Thr Leu
         115                 120                 125

 acg gcc agc gag gag gcc atg gcg gtg ctg gag gag gtg gtg ctg tac      851
 Thr Ala Ser Glu Glu Ala Met Ala Val Leu Glu Glu Val Val Leu Tyr
     130                 135                 140

 gcc ttc cag cag tgc gtc tac tat gtc tcc aag tcc ctg tac atc tgc      899
 Ala Phe Gln Gln Cys Val Tyr Tyr Val Ser Lys Ser Leu Tyr Ile Cys
 145                 150                 155                 160

 ctc ccg gca ctc ctg gag tgc ccg cca ttc cag acg gag cgc cgt gag      947
 Leu Pro Ala Leu Leu Glu Cys Pro Pro Phe Gln Thr Glu Arg Arg Glu
                 165                 170                 175

 agc tgg tcc tcg gcc ccc gaa ctg ccc gag gag ctg cgc cgc gtg gtg      995
 Ser Trp Ser Ser Ala Pro Glu Leu Pro Glu Glu Leu Arg Arg Val Val
             180                 185                 190

 tct gtg tac cag gca gcc ctg gac ctc ctg cgg cag ctg cag gtg cac     1043
 Ser Val Tyr Gln Ala Ala Leu Asp Leu Leu Arg Gln Leu Gln Val His
         195                 200                 205

 ccc gag gtg gcc tcg cag atg ctc gcc tac ctc ttc ttc ttc tcc ggg     1091
 Pro Glu Val Ala Ser Gln Met Leu Ala Tyr Leu Phe Phe Phe Ser Gly
     210                 215                 220

 aca ctg ctt ctc aac cag ctc ctc gac agg ggc ccc tcc ctg agc tgc     1139
 Thr Leu Leu Leu Asn Gln Leu Leu Asp Arg Gly Pro Ser Leu Ser Cys
 225                 230                 235                 240

 ttc cac tgg ccc aga ggt gtc cag gcc tgc gcc cgc ctg cag cag ctc     1187
 Phe His Trp Pro Arg Gly Val Gln Ala Cys Ala Arg Leu Gln Gln Leu
                 245                 250                 255

 ctg gag tgg atg cgg agc gcc ggc ttc ggg gcg gct gga gag cac ttc     1235
 Leu Glu Trp Met Arg Ser Ala Gly Phe Gly Ala Ala Gly Glu His Phe
             260                 265                 270

 ttc cag aag ctc tcc tgc acc ctc aac ctg ctg gcc aca ccc agg gcc     1283
 Phe Gln Lys Leu Ser Cys Thr Leu Asn Leu Leu Ala Thr Pro Arg Ala
         275                 280                 285

 cag ctc atc cag atg agc tgg aca gcc ctg cgg gct gcg ttc ccc gca     1331
 Gln Leu Ile Gln Met Ser Trp Thr Ala Leu Arg Ala Ala Phe Pro Ala
     290                 295                 300

 ctg agc cca gca cag ctg cac cgg ctg ctg act cac tac cag ctg gcc     1379
 Leu Ser Pro Ala Gln Leu His Arg Leu Leu Thr His Tyr Gln Leu Ala
 305                 310                 315                 320

 tcg gcc atg ggc ccc atg agc acc tgg gag cca ggg gcc cag gac agc     1427
 Ser Ala Met Gly Pro Met Ser Thr Trp Glu Pro Gly Ala Gln Asp Ser
                 325                 330                 335

 ccc gag gcc ttc agg tca gag gat gtt ctg gag tcc tac gaa aac ccc     1475
 Pro Glu Ala Phe Arg Ser Glu Asp Val Leu Glu Ser Tyr Glu Asn Pro
             340                 345                 350

 cca ccc atc gtc ctg ccc agc gac ggc ttc cag gtg gac ttg gaa gcc     1523
 Pro Pro Ile Val Leu Pro Ser Asp Gly Phe Gln Val Asp Leu Glu Ala
         355                 360                 365

 aac tgc ctg gac gac agc atc tac cag cac ctg ctc tac gtc cgc cac     1571
 Asn Cys Leu Asp Asp Ser Ile Tyr Gln His Leu Leu Tyr Val Arg His
     370                 375                 380

 ttt ctg tgg ggt ctg cgg agc aga gcc agc ccc ggc agc cct ggc agg     1619
 Phe Leu Trp Gly Leu Arg Ser Arg Ala Ser Pro Gly Ser Pro Gly Arg
 385                 390                 395                 400

 cct ggc agt ggg gcc tcc cag cca gtg tgc ccc gag ggt atg cac cac     1667
 Pro Gly Ser Gly Ala Ser Gln Pro Val Cys Pro Glu Gly Met His His
                 405                 410                 415

 gtg gtc ctt gac ggg cac ctg gag gcc ccg agc tgc ccc ctg gct ccc     1715
 Val Val Leu Asp Gly His Leu Glu Ala Pro Ser Cys Pro Leu Ala Pro
             420                 425                 430

 agg gac cct ggc cca gca gcc cgg gaa gtg gcc ccg gag cgt act ctt     1763
 Arg Asp Pro Gly Pro Ala Ala Arg Glu Val Ala Pro Glu Arg Thr Leu
         435                 440                 445

 ccc ttg agg ggg gct ccc tgg gca cag gcc ccc cct gga agg caa ccc     1811
 Pro Leu Arg Gly Ala Pro Trp Ala Gln Ala Pro Pro Gly Arg Gln Pro
     450                 455                 460

 ggc cgt ggg ggc tcc cag gct ggc ccc ccg cac acg gac tcg tcc tgc     1859
 Gly Arg Gly Gly Ser Gln Ala Gly Pro Pro His Thr Asp Ser Ser Cys
 465                 470                 475                 480

 ttg ctc acg cct ccc agc act cca ctt ggc cct gag cct ggg gac ccc     1907
 Leu Leu Thr Pro Pro Ser Thr Pro Leu Gly Pro Glu Pro Gly Asp Pro
                 485                 490                 495

 gac tgg cca gag tcc ggc ggc ccc tgt gga aaa gcg ctc cca gag agg     1955
 Asp Trp Pro Glu Ser Gly Gly Pro Cys Gly Lys Ala Leu Pro Glu Arg
             500                 505                 510

 cag agg aac gga ctc agc ggc ctc cgg ggt gca gct ccg gaa gga gac     2003
 Gln Arg Asn Gly Leu Ser Gly Leu Arg Gly Ala Ala Pro Glu Gly Asp
         515                 520                 525

 tct gca gcc ctt gcg gag gag tcc cct cca gcc ccg tcc agc cgc agc     2051
 Ser Ala Ala Leu Ala Glu Glu Ser Pro Pro Ala Pro Ser Ser Arg Ser
     530                 535                 540

 tcc agc acc gag gac ttc tgc tac gtc ttc acg gtg gag ctg gaa cga     2099
 Ser Ser Thr Glu Asp Phe Cys Tyr Val Phe Thr Val Glu Leu Glu Arg
 545                 550                 555                 560

 ggc ccc tcc ggg ctg ggg atg ggc ctg atc gac ggg atg cac acg cac     2147
 Gly Pro Ser Gly Leu Gly Met Gly Leu Ile Asp Gly Met His Thr His
                 565                 570                 575

 ctg ggc gcc ccc ggg ctc tac atc cag acc ctg ctc ccg ggc agc ccc     2195
 Leu Gly Ala Pro Gly Leu Tyr Ile Gln Thr Leu Leu Pro Gly Ser Pro
             580                 585                 590

 gca gcg gcc gac ggg cgc ctg tcg ctg ggg gac cgt atc ctg gag gtg     2243
 Ala Ala Ala Asp Gly Arg Leu Ser Leu Gly Asp Arg Ile Leu Glu Val
         595                 600                 605

 aat ggc agc agc ctc ctg ggc ctt ggc tac ctg aga gct gtg gac ctg     2291
 Asn Gly Ser Ser Leu Leu Gly Leu Gly Tyr Leu Arg Ala Val Asp Leu
     610                 615                 620

 atc cgt cat ggc ggg aag aag atg cgg ttc ctg gtc gcg aag tcc gac     2339
 Ile Arg His Gly Gly Lys Lys Met Arg Phe Leu Val Ala Lys Ser Asp
 625                 630                 635                 640

 gtg gaa aca gcc aag aag atc cat ttc cgc acg ccc cct ctc tag ggg     2387
 Val Glu Thr Ala Lys Lys Ile His Phe Arg Thr Pro Pro Leu 
                 645                 650

 ggctgcgagg acacccccac aggcccggca cccggtccca cctggtgaca ctgggcttcc   2447

 tcccgccttc gtccctgttt tgtaactgac caagttgggt cccgggtggg gagcctcacc   2507

 ctggggacat gcctgttgat aacatgcatc tcagtgtagg ttctatttat atggcagatg   2567

 acgtgaaatt gtgatgtttg ttacagagct tttatgttta aagacttcaa tggagaagta   2627

 cggttcaata aactattttt cccgttctta aaaaaaaaaa aa                      2669




      <210> 232
      <211> 2302
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1944)

      <400> 232
  atg ggc aag tac acg gtc cgc gta gcc acc ggg gat ttg ctc ctg gcg      48
  Met Gly Lys Tyr Thr Val Arg Val Ala Thr Gly Asp Leu Leu Leu Ala
    1               5                  10                  15

 ggc tct ccc aac ctg gtg cag cta tgg ctg gtg ggc gag cac ggg gag       96
 Gly Ser Pro Asn Leu Val Gln Leu Trp Leu Val Gly Glu His Gly Glu
              20                  25                  30

 gca gac cta ggg aag cag ctg cca ccg gtg tgg gga aag gag gca gag      144
 Ala Asp Leu Gly Lys Gln Leu Pro Pro Val Trp Gly Lys Glu Ala Glu
          35                  40                  45

 ttt gag atc gac gtc ccc ctg cac ctg ggg cgc ctc ctg atg gtg aag      192
 Phe Glu Ile Asp Val Pro Leu His Leu Gly Arg Leu Leu Met Val Lys
      50                  55                  60

 ctg cgc aaa cac aac gtg ctg ttg agt ctc gac tgg ttc tgc aag tgg      240
 Leu Arg Lys His Asn Val Leu Leu Ser Leu Asp Trp Phe Cys Lys Trp
  65                  70                  75                  80

 atc tca gtg cag ggc ccg ggg acc caa ggc gag gcc ttt ttc ccc tgc      288
 Ile Ser Val Gln Gly Pro Gly Thr Gln Gly Glu Ala Phe Phe Pro Cys
                  85                  90                  95

 tac cgc tgg gtg cag ggc cac gga att atc tgc ctg cct gag ggt act      336
 Tyr Arg Trp Val Gln Gly His Gly Ile Ile Cys Leu Pro Glu Gly Thr
             100                 105                 110

 gcc cgg acc gtg agt gat gac ccc cag aac ctg ttt aag aaa tat cgg      384
 Ala Arg Thr Val Ser Asp Asp Pro Gln Asn Leu Phe Lys Lys Tyr Arg
         115                 120                 125

 gaa cag gag ctc gag gaa aga agg aag gct tcc tcc agg tgg ggc tcc      432
 Glu Gln Glu Leu Glu Glu Arg Arg Lys Ala Ser Ser Arg Trp Gly Ser
     130                 135                 140

 tgg aaa gat ggg tta atc ctg cct ata gca ggg aat agg caa ccg gac      480
 Trp Lys Asp Gly Leu Ile Leu Pro Ile Ala Gly Asn Arg Gln Pro Asp
 145                 150                 155                 160

 ctt cct agg gac gag cga ttc ctc gag gat aag gat tta gac ttt aat      528
 Leu Pro Arg Asp Glu Arg Phe Leu Glu Asp Lys Asp Leu Asp Phe Asn
                 165                 170                 175

 gtc tcc cta gca aaa ggg gac ttg gcc att aag ggg aca ctg gat ttc      576
 Val Ser Leu Ala Lys Gly Asp Leu Ala Ile Lys Gly Thr Leu Asp Phe
             180                 185                 190

 ata aat tgt gtg aaa agg ctg gaa gat ttc aaa aaa ata ttc cca cat      624
 Ile Asn Cys Val Lys Arg Leu Glu Asp Phe Lys Lys Ile Phe Pro His
         195                 200                 205

 gga aag act gtc ctg gct gag cgg gtt tat gat tct tgg aag aat gat      672
 Gly Lys Thr Val Leu Ala Glu Arg Val Tyr Asp Ser Trp Lys Asn Asp
     210                 215                 220

 gcc ttc ttt ggg tac cag ttt ctc aat ggt gca aac ccc atg ctc ctg      720
 Ala Phe Phe Gly Tyr Gln Phe Leu Asn Gly Ala Asn Pro Met Leu Leu
 225                 230                 235                 240

 agg tgt tct tca agg ctc cca gcc tgc ctg gtg ctg cct cca ggg atg      768
 Arg Cys Ser Ser Arg Leu Pro Ala Cys Leu Val Leu Pro Pro Gly Met
                 245                 250                 255

 gaa gac ttg aag acc cag ctg gag aaa gaa ctc cag gct gga tct ctg      816
 Glu Asp Leu Lys Thr Gln Leu Glu Lys Glu Leu Gln Ala Gly Ser Leu
             260                 265                 270

 ttt gaa gtg gat ttc tcc ttg ctg gat gga gtc aag cct aat gtc atc      864
 Phe Glu Val Asp Phe Ser Leu Leu Asp Gly Val Lys Pro Asn Val Ile
         275                 280                 285

 att ttt aag cag caa tgc gtg gca gcc cct ttg gtc atg ctg aag ctt      912
 Ile Phe Lys Gln Gln Cys Val Ala Ala Pro Leu Val Met Leu Lys Leu
     290                 295                 300

 cag cct gat gga gga ctc tta ccc atg gtc atc cag ctc cag cca cct      960
 Gln Pro Asp Gly Gly Leu Leu Pro Met Val Ile Gln Leu Gln Pro Pro
 305                 310                 315                 320

 cac gga tgt ccc cca cct ctg ctc ttt ctg ccc tcg cat ccc ccc atg     1008
 His Gly Cys Pro Pro Pro Leu Leu Phe Leu Pro Ser His Pro Pro Met
                 325                 330                 335

 gcc tgg ctc ctg gcc aag acc tgg gtc cgg agc tct gat ttc cag ctg     1056
 Ala Trp Leu Leu Ala Lys Thr Trp Val Arg Ser Ser Asp Phe Gln Leu
             340                 345                 350

 cag cag tta cag tca cat ctg ctg agg gga cac ttg att gct gag gtt     1104
 Gln Gln Leu Gln Ser His Leu Leu Arg Gly His Leu Ile Ala Glu Val
         355                 360                 365

 att gct gtg gct aca atg aga agc ttg cct agc ctc cat cct atc tac     1152
 Ile Ala Val Ala Thr Met Arg Ser Leu Pro Ser Leu His Pro Ile Tyr
     370                 375                 380

 aag ctc ctg atc ccc cac ttc cgc tac acc atg gcg atc aac acg ctg     1200
 Lys Leu Leu Ile Pro His Phe Arg Tyr Thr Met Ala Ile Asn Thr Leu
 385                 390                 395                 400

 gcc cag agt agt ctt gtc tcc gaa tgg gga att ttt gac ctg gtg gtg     1248
 Ala Gln Ser Ser Leu Val Ser Glu Trp Gly Ile Phe Asp Leu Val Val
                 405                 410                 415

 agc act ggt agt gga agc cac gtg gac att ctt cag aga gcc atg gct     1296
 Ser Thr Gly Ser Gly Ser His Val Asp Ile Leu Gln Arg Ala Met Ala
             420                 425                 430

 tgt ttg acc tat cat tcc ctc tgt cct cct gat gac ctg gct gac cgt     1344
 Cys Leu Thr Tyr His Ser Leu Cys Pro Pro Asp Asp Leu Ala Asp Arg
         435                 440                 445

 ggg ctc ctg gat gtg aaa tct tct ttt tat ggc gat gcc atc agg ctg     1392
 Gly Leu Leu Asp Val Lys Ser Ser Phe Tyr Gly Asp Ala Ile Arg Leu
     450                 455                 460

 tgg gga atc atc agc cgg tac atg gag ggg atg gtt ggg ctt ttc tac     1440
 Trp Gly Ile Ile Ser Arg Tyr Met Glu Gly Met Val Gly Leu Phe Tyr
 465                 470                 475                 480

 aat agt gac caa gcc atg aag gat gat cta gag ctg cag gcc tgg tgc     1488
 Asn Ser Asp Gln Ala Met Lys Asp Asp Leu Glu Leu Gln Ala Trp Cys
                 485                 490                 495

 aga gag atg act gag act gga ctg cag agg gcc caa gac cag ggg ttc     1536
 Arg Glu Met Thr Glu Thr Gly Leu Gln Arg Ala Gln Asp Gln Gly Phe
             500                 505                 510

 ctc atc tcc tta gag tcc cgg gct cag ctc tgc cac ttt gtc acc atg     1584
 Leu Ile Ser Leu Glu Ser Arg Ala Gln Leu Cys His Phe Val Thr Met
         515                 520                 525

 tgc atc ttc aca tgc aca ggt cag cat gct tct aac cac ctg ggc cag     1632
 Cys Ile Phe Thr Cys Thr Gly Gln His Ala Ser Asn His Leu Gly Gln
     530                 535                 540

 ctg gac tgg tac tcc tgg atc cct aat ggc cca tgc acc atg cag aag     1680
 Leu Asp Trp Tyr Ser Trp Ile Pro Asn Gly Pro Cys Thr Met Gln Lys
 545                 550                 555                 560

 ccc cca ccc atc tct aag gat gtg aca gag aag gat ata gtg gac tta     1728
 Pro Pro Pro Ile Ser Lys Asp Val Thr Glu Lys Asp Ile Val Asp Leu
                 565                 570                 575

 ctg ccc aat ctc cac cag gca cgt atg caa aag acc ttc aca aag ttc     1776
 Leu Pro Asn Leu His Gln Ala Arg Met Gln Lys Thr Phe Thr Lys Phe
             580                 585                 590

 ctt ggc aga cgc cag cct gtc atg gtg aga agc aaa cat gag gag aaa     1824
 Leu Gly Arg Arg Gln Pro Val Met Val Arg Ser Lys His Glu Glu Lys
         595                 600                 605

 tat ttc tct ggt cct gag ccc caa gct gtg ctg aga caa ttc cag gag     1872
 Tyr Phe Ser Gly Pro Glu Pro Gln Ala Val Leu Arg Gln Phe Gln Glu
     610                 615                 620

 gaa ctg gct tcc atg gac aag gag att gag gtc cgg aat gca gtc ctg     1920
 Glu Leu Ala Ser Met Asp Lys Glu Ile Glu Val Arg Asn Ala Val Leu
 625                 630                 635                 640

 gac ctg ccc tgt gag tac ctt tga cccagcatgg tagagaacag cgtgaccatc    1974
 Asp Leu Pro Cys Glu Tyr Leu 
                 645

 tgagaggcct tgcccgcctc agctccaaag ctccaccatc cctgagtgcc tttgagtatt   2034

 ccgtcctcct cacatcctct ggtgaacaaa ttgtccccaa agctttgtgg tcagggtatc   2094

 cagagctgct caccacacaa ctatggggaa tacacagtga tggtccccat tgcatttgga   2154

 agtggcatcc cccaaagctg ccctacctta aatgtccatc cagtcctgca cttcctcacc   2214

 ccgatccctg cacacctcct cattgccaaa ggacctggct tagatacaag taaaaatata   2274

 tgattaaata acaaaaaaaa aaaaaaaa                                      2302




      <210> 233
      <211> 2218
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(882)

      <400> 233
  atg ggc aag tac acg gtc cgc gta gcc acc ggg gat ttg ctc ctg gcg      48
  Met Gly Lys Tyr Thr Val Arg Val Ala Thr Gly Asp Leu Leu Leu Ala
    1               5                  10                  15

 ggc tct ccc aac ctg gtg cag cta tgg ctg gtg ggc gag cac ggg gag       96
 Gly Ser Pro Asn Leu Val Gln Leu Trp Leu Val Gly Glu His Gly Glu
              20                  25                  30

 gca gac cta ggg aag cag ctg cca ccg gtg tgg gga aag gag gca gag      144
 Ala Asp Leu Gly Lys Gln Leu Pro Pro Val Trp Gly Lys Glu Ala Glu
          35                  40                  45

 ttt gag atc gac gtc ccc ctg cac ctg ggg cgc ctc ctg atg gtg aag      192
 Phe Glu Ile Asp Val Pro Leu His Leu Gly Arg Leu Leu Met Val Lys
      50                  55                  60

 ctg cgc aaa cac aac gtg ctg ttg agt ctc gac tgg ttc tgc aag tgg      240
 Leu Arg Lys His Asn Val Leu Leu Ser Leu Asp Trp Phe Cys Lys Trp
  65                  70                  75                  80

 atc tca gtg cag ggc ccg ggg acc caa ggc gag gcc ttt ttc ccc tgc      288
 Ile Ser Val Gln Gly Pro Gly Thr Gln Gly Glu Ala Phe Phe Pro Cys
                  85                  90                  95

 tac cgc tgg gtg cag ggc cac gga att atc tgc ctg cct gag ggt agg      336
 Tyr Arg Trp Val Gln Gly His Gly Ile Ile Cys Leu Pro Glu Gly Arg
             100                 105                 110

 tgg ggc tcc tgg aaa gat ggg tta atc ctg cct ata gca ggg aat agg      384
 Trp Gly Ser Trp Lys Asp Gly Leu Ile Leu Pro Ile Ala Gly Asn Arg
         115                 120                 125

 caa ccg gac ctt cct agg gac gag cga ttc ctc gag gat aag gat tta      432
 Gln Pro Asp Leu Pro Arg Asp Glu Arg Phe Leu Glu Asp Lys Asp Leu
     130                 135                 140

 gac ttt aat gtc tcc cta gca aaa ggg ttg aag gac ttg gcc att aag      480
 Asp Phe Asn Val Ser Leu Ala Lys Gly Leu Lys Asp Leu Ala Ile Lys
 145                 150                 155                 160

 ggg aca ctg gat ttc ata aat tgt gtg aaa agg ctg gaa gat ttc aaa      528
 Gly Thr Leu Asp Phe Ile Asn Cys Val Lys Arg Leu Glu Asp Phe Lys
                 165                 170                 175

 aaa ata ttc cca cat gga aag act gtc ctg gct gag cgg gtt tat gat      576
 Lys Ile Phe Pro His Gly Lys Thr Val Leu Ala Glu Arg Val Tyr Asp
             180                 185                 190

 tct tgg aag aat gat gcc ttc ttt ggg tac cag ttt ctc aat ggt gca      624
 Ser Trp Lys Asn Asp Ala Phe Phe Gly Tyr Gln Phe Leu Asn Gly Ala
         195                 200                 205

 aac ccc atg ctc ctg agg tgt tct tca agg ctc cca gcc tgc ctg gtg      672
 Asn Pro Met Leu Leu Arg Cys Ser Ser Arg Leu Pro Ala Cys Leu Val
     210                 215                 220

 ctg cct cca ggg atg gaa gac ttg aag acc cag ctg gag aaa gaa ctc      720
 Leu Pro Pro Gly Met Glu Asp Leu Lys Thr Gln Leu Glu Lys Glu Leu
 225                 230                 235                 240

 cag gct gga tct ctg ttt gaa gtg gat ttc tcc ttg ctg gat gga gtc      768
 Gln Ala Gly Ser Leu Phe Glu Val Asp Phe Ser Leu Leu Asp Gly Val
                 245                 250                 255

 aag cct aat gtc atc att ttt aag cag caa tgc gtg gca gcc cct ttg      816
 Lys Pro Asn Val Ile Ile Phe Lys Gln Gln Cys Val Ala Ala Pro Leu
             260                 265                 270

 gtc atg ctg aag ctt cag cct gat gga gga ctc tta ccc atg gtc atc      864
 Val Met Leu Lys Leu Gln Pro Asp Gly Gly Leu Leu Pro Met Val Ile
         275                 280                 285

 cag ctc cag cca cct tga cacgga tgtcccccac ctctgctctt tctgccctcg      918
 Gln Leu Gln Pro Pro 
     290

 catcccccca tggcctggct cctggccaag acctgggtcc ggagctctga tttccagctg    978

 cagcagttac agtcacatct gctgagggga cacttgattg ctgaggttat tgctgtggct   1038

 acaatgagaa gcttgcctag cctccatcct atctacaagc tcctgatccc ccacttccgc   1098

 tacaccatgg cgatcaacac gctggcccag agtagtcttg tctccgaatg gggaattttt   1158

 gacctggtgg tgagcactgg tagtggaagc cacgtggaca ttcttcagag agccatggct   1218

 tgtttgacct atcattccct ctgtcctcct gatgacctgg ctgaccgtgg gctcctggat   1278

 gtgaaatctt ctttttatgg ctaagatgcc atcaggctgt ggggaatcat cagccgggat   1338

 acgtggaggg gatggttggg cttttctaca atagtgacca agccatgaag gatgatctag   1398

 agctgcaggc ctggtgcaga gagatgactg agactggact gcagagggcc caagaccagg   1458

 ggttcctcat ctccttagag tcccgggctc agctctgcca ctttgtcacc atgtgcatct   1518

 tcacatgcac aggtcagcat gcttctaacc acctgggcca gctggactgg tactcctgga   1578

 tccctaatgg cccatgcacc atgcagaagc ccccgcccat ctctaaggat gtgacagaga   1638

 aggatatagt ggacttactg cccaatctcc accaggcacg tatgcaaaag accttcacaa   1698

 agttccttgg cagacgccag cctgtcatgc atgaggagaa atatttctct ggtcctgagc   1758

 cccaagctgt gctgagacaa ttccaggagg aactggcttc catggacaag gagattgagg   1818

 tccggaatgc agtcctggac ctgccctgtg agtacctttg acccagcatg gtagagaaca   1878

 gcgtgaccat ctgagaggcc ttgcccgcct cagctccaaa gctccaccat ccctgagtgc   1938

 ctttgagtat tccgtcctcc tcacatcctc tggtgaacaa attgtcccca aagctttgtg   1998

 gtcagggtat ccagagctgc tcaccacaca actatgggga atacacagtg atggtcccca   2058

 ttgcatttgg aagtggcatc ccccaaagct gccctacctt aaatgtccat ccagtcctgc   2118

 acttcctcac cccgatccct gcacacctcc tcattgccaa aggacctggc ttagatacaa   2178

 gtaaaaatat atgattaaat aacaaaaaaa aaaaaaaaaa                         2218




      <210> 234
      <211> 2311
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(969)

      <400> 234
  atg ggc aag tac acg gtc cgc gta gcc acc ggg gat ttg ctc ctg gcg      48
  Met Gly Lys Tyr Thr Val Arg Val Ala Thr Gly Asp Leu Leu Leu Ala
    1               5                  10                  15

 ggc tct ccc aac ctg gtg cag cta tgg ctg gtg ggc gag cac ggg gag       96
 Gly Ser Pro Asn Leu Val Gln Leu Trp Leu Val Gly Glu His Gly Glu
              20                  25                  30

 gca gac cta ggg aag cag ctg cca ccg gtg tgg gga aag gag gca gag      144
 Ala Asp Leu Gly Lys Gln Leu Pro Pro Val Trp Gly Lys Glu Ala Glu
          35                  40                  45

 ttt gag atc gac gtc ccc ctg cac ctg ggg cgc ctc ctg atg gtg aag      192
 Phe Glu Ile Asp Val Pro Leu His Leu Gly Arg Leu Leu Met Val Lys
      50                  55                  60

 ctg cgc aaa cac aac gtg ctg ttg agt ctc gac tgg ttc tgc aag tgg      240
 Leu Arg Lys His Asn Val Leu Leu Ser Leu Asp Trp Phe Cys Lys Trp
  65                  70                  75                  80

 atc tca gtg cag ggc ccg ggg acc caa ggc gag gcc ttt ttc ccc tgc      288
 Ile Ser Val Gln Gly Pro Gly Thr Gln Gly Glu Ala Phe Phe Pro Cys
                  85                  90                  95

 tac cgc tgg gtg cag ggc cac gga att atc tgc ctg cct gag ggt act      336
 Tyr Arg Trp Val Gln Gly His Gly Ile Ile Cys Leu Pro Glu Gly Thr
             100                 105                 110

 gcc cgg acc gtg agt gat gac ccc cag aac ctg ttt aag aaa tat cgg      384
 Ala Arg Thr Val Ser Asp Asp Pro Gln Asn Leu Phe Lys Lys Tyr Arg
         115                 120                 125

 gaa cag gag ctc gag gaa aga agg aag gct tcc tcc agg tgg ggc tcc      432
 Glu Gln Glu Leu Glu Glu Arg Arg Lys Ala Ser Ser Arg Trp Gly Ser
     130                 135                 140

 tgg aaa gat ggg tta atc ctg cct ata gca ggg aat agg caa ccg gac      480
 Trp Lys Asp Gly Leu Ile Leu Pro Ile Ala Gly Asn Arg Gln Pro Asp
 145                 150                 155                 160

 ctt cct agg gac gag cga ttc ctc gag gat aag gat tta gac ttt aat      528
 Leu Pro Arg Asp Glu Arg Phe Leu Glu Asp Lys Asp Leu Asp Phe Asn
                 165                 170                 175

 gtc tcc cta gca aaa ggg ttg aag gac ttg gcc att aag ggg aca ctg      576
 Val Ser Leu Ala Lys Gly Leu Lys Asp Leu Ala Ile Lys Gly Thr Leu
             180                 185                 190

 gat ttc ata aat tgt gtg aaa agg ctg gaa gat ttc aaa aaa ata ttc      624
 Asp Phe Ile Asn Cys Val Lys Arg Leu Glu Asp Phe Lys Lys Ile Phe
         195                 200                 205

 cca cat gga aag act gtc ctg gct gag cgg gtt tat gat tct tgg aag      672
 Pro His Gly Lys Thr Val Leu Ala Glu Arg Val Tyr Asp Ser Trp Lys
     210                 215                 220

 aat gat gcc ttc ttt ggg tac cag ttt ctc aat ggt gca aac ccc atg      720
 Asn Asp Ala Phe Phe Gly Tyr Gln Phe Leu Asn Gly Ala Asn Pro Met
 225                 230                 235                 240

 ctc ctg agg tgt tct tca agg ctc cca gcc tgc ctg gtg ctg cct cca      768
 Leu Leu Arg Cys Ser Ser Arg Leu Pro Ala Cys Leu Val Leu Pro Pro
                 245                 250                 255

 ggg atg gaa gac ttg aag acc cag ctg gag aaa gaa ctc cag gct gga      816
 Gly Met Glu Asp Leu Lys Thr Gln Leu Glu Lys Glu Leu Gln Ala Gly
             260                 265                 270

 tct ctg ttt gaa gtg gat ttc tcc ttg ctg gat gga gtc aag cct aat      864
 Ser Leu Phe Glu Val Asp Phe Ser Leu Leu Asp Gly Val Lys Pro Asn
         275                 280                 285

 gtc atc att ttt aag cag caa tgc gtg gca gcc cct ttg gtc atg ctg      912
 Val Ile Ile Phe Lys Gln Gln Cys Val Ala Ala Pro Leu Val Met Leu
     290                 295                 300

 aag ctt cag cct gat gga gga ctc tta ccc atg gtc atc cag ctc cag      960
 Lys Leu Gln Pro Asp Gly Gly Leu Leu Pro Met Val Ile Gln Leu Gln
 305                 310                 315                 320

 cca cct tga cacggat gtcccccacc tctgctcttt ctgccctcgc atccccccat     1016
 Pro Pro 


 ggcctggctc ctggccaaga cctgggtccg gagctctgat ttccagctgc agcagttaca   1076

 gtcacatctg ctgaggggac acttgattgc tgaggttatt gctgtggcta caatgagaag   1136

 cttgcctagc ctccatccta tctacaagct cctgatcccc cacttccgct acaccatggc   1196

 gatcaacacg ctggcccaga gtagtcttgt ctccgaatgg ggaatttttg acctggtggt   1256

 gagcactggt agtggaagcc acgtggacat tcttcagaga gccatggctt gtttgaccta   1316

 tcattccctc tgtcctcctg atgacctggc tgaccgtggg ctcctggatg tgaaatcttc   1376

 tttttatggc gatgccatca ggctgtgggg aatcatcagc cggtacatgg aggggatggt   1436

 tgggcttttc tacaatagtg accaagccat gaaggatgat ctagagctgc aggcctggtg   1496

 cagagagatg actgagactg gactgcagag ggcccaagac caggggttcc tcatctcctt   1556

 agagtcccgg gctcagctct gccactttgt caccatgtgc atcttcacat gcacaggtca   1616

 gcatgcttct aaccacctgg gccagctgga ctggtactcc tggatcccta atggcccatg   1676

 caccatgcag aagcccccac ccatctctaa ggatgtgaca gagaaggata tagtggactt   1736

 actgcccaat ctccaccagg cacgtatgca aaagaccttc acaaagttcc ttggcagacg   1796

 ccagcctgtc atggtgagaa gcaaacatga ggagaaatat ttctctggtc ctgagcccca   1856

 agctgtgctg agacaattcc aggaggaact ggcttccatg gacaaggaga ttgaggtccg   1916

 gaatgcagtc ctggacctgc cctgtgagta cctttgaccc agcatggtag agaacagcgt   1976

 gaccatctga gaggccttgc ccgcctcagc tccaaagctc caccatccct gagtgccttt   2036

 gagtattccg tcctcctcac atcctctggt gaacaaattg tccccaaagc tttgtggtca   2096

 gggtatccag agctgctcac cacacaacta tggggaatac acagtgatgg tccccattgc   2156

 atttggaagt ggcatccccc aaagctgccc taccttaaat gtccatccag tcctgcactt   2216

 cctcaccccg atccctgcac acctcctcat tgccaaagga cctggcttag atacaagtaa   2276

 aaatatatga ttaaataaca aaaaaaaaaa aaaaa                              2311




      <210> 235
      <211> 2403
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (214)..(2403)

      <400> 235
 agcggacggg tgtacacagc agcggcgccg cggcccgcag ccccgcggcg gcggcaaagg     60

 taaccgaccc gccctggggt gctgcgtgcg ctgcctgctc ccgcctgagg aaaacactgc    120

 ccatggcgca aggccgggag cgcgacgaag gcccccactc cgccggcggc gcgtccttgt    180

 ccgtgagatg ggtgcaagga ttccctaagc aga atg ttc att ttg tca acg aca     234
                                      Met Phe Ile Leu Ser Thr Thr
                                        1               5

 aca cca ttt gct acc ctt gtg gga act tat gta ata ttt att aat att      282
 Thr Pro Phe Ala Thr Leu Val Gly Thr Tyr Val Ile Phe Ile Asn Ile
          10                  15                  20

 gaa acc aag aaa aag act gta ctg cag tgt agt aat gga att gtg ggc      330
 Glu Thr Lys Lys Lys Thr Val Leu Gln Cys Ser Asn Gly Ile Val Gly
      25                  30                  35

 gtc atg gca act aac atc ccc tgt gaa gtt gtg gct ttt tct gac cgg      378
 Val Met Ala Thr Asn Ile Pro Cys Glu Val Val Ala Phe Ser Asp Arg
  40                  45                  50                  55

 aag cta aaa cct ctc atc tac gta tac agc ttt cca gga ttg acc aga      426
 Lys Leu Lys Pro Leu Ile Tyr Val Tyr Ser Phe Pro Gly Leu Thr Arg
                  60                  65                  70

 agg acc aaa ttg aaa ggc aac att ctc ctg gac tac act tta ctt tca      474
 Arg Thr Lys Leu Lys Gly Asn Ile Leu Leu Asp Tyr Thr Leu Leu Ser
              75                  80                  85

 ttc agt tac tgt ggc acc tac ctg gct agt tac tcc tct ctc cca gaa      522
 Phe Ser Tyr Cys Gly Thr Tyr Leu Ala Ser Tyr Ser Ser Leu Pro Glu
          90                  95                 100

 ttt gaa ctg gcc ctt tgg aac tgg gaa tcg agt atc att ttg tgt aag      570
 Phe Glu Leu Ala Leu Trp Asn Trp Glu Ser Ser Ile Ile Leu Cys Lys
     105                 110                 115

 aaa tca cag cct gga atg gat gtg aac caa atg tct ttt aac ccc atg      618
 Lys Ser Gln Pro Gly Met Asp Val Asn Gln Met Ser Phe Asn Pro Met
 120                 125                 130                 135

 aac tgg cgc cag ctg tgc tta tca agt cca agt aca gtg agc gtg tgg      666
 Asn Trp Arg Gln Leu Cys Leu Ser Ser Pro Ser Thr Val Ser Val Trp
                 140                 145                 150

 acc att gaa aga agt aac cag gag cat tgt ttc aga gca agg tcg gtg      714
 Thr Ile Glu Arg Ser Asn Gln Glu His Cys Phe Arg Ala Arg Ser Val
             155                 160                 165

 aaa tta cct cta gaa gat ggg tca ttt ttt aat gaa acg gat gtc gtt      762
 Lys Leu Pro Leu Glu Asp Gly Ser Phe Phe Asn Glu Thr Asp Val Val
         170                 175                 180

 ttc ccc cag tcg ttg ccg aaa gat ctc atc tat ggt ccc gtg ctg cca      810
 Phe Pro Gln Ser Leu Pro Lys Asp Leu Ile Tyr Gly Pro Val Leu Pro
     185                 190                 195

 ctg tca gcc att gcc ggg ctg gta ggc aaa gag gca gag act ttc cgg      858
 Leu Ser Ala Ile Ala Gly Leu Val Gly Lys Glu Ala Glu Thr Phe Arg
 200                 205                 210                 215

 ccg aaa gat gat cta tat cct ttg ctt cac ccg act atg cat tgc tgg      906
 Pro Lys Asp Asp Leu Tyr Pro Leu Leu His Pro Thr Met His Cys Trp
                 220                 225                 230

 act cca aca agt gac ttg tac att ggc tgt gaa gag ggt cat ctt tta      954
 Thr Pro Thr Ser Asp Leu Tyr Ile Gly Cys Glu Glu Gly His Leu Leu
             235                 240                 245

 atg att aat gga gac acc ttg caa gtg act gta ctt aat aag ata gaa     1002
 Met Ile Asn Gly Asp Thr Leu Gln Val Thr Val Leu Asn Lys Ile Glu
         250                 255                 260

 gag gaa tcg cca ttg gaa gac aga aga aat ttt atc agt cca gta acc     1050
 Glu Glu Ser Pro Leu Glu Asp Arg Arg Asn Phe Ile Ser Pro Val Thr
     265                 270                 275

 ttg gta tat cag aag gag ggc gtg ctg gct tct gga att gat ggc ttt     1098
 Leu Val Tyr Gln Lys Glu Gly Val Leu Ala Ser Gly Ile Asp Gly Phe
 280                 285                 290                 295

 gtg tat tct ttt att att aaa gat aga agt tac atg atc gag gat ttt     1146
 Val Tyr Ser Phe Ile Ile Lys Asp Arg Ser Tyr Met Ile Glu Asp Phe
                 300                 305                 310

 ctt gag att gaa aga cct gta gaa cat atg aca ttt tct ccc aat tat     1194
 Leu Glu Ile Glu Arg Pro Val Glu His Met Thr Phe Ser Pro Asn Tyr
             315                 320                 325

 aca gtg ttg ctg att caa aca gac aag gga tct gtt tat atc tac act     1242
 Thr Val Leu Leu Ile Gln Thr Asp Lys Gly Ser Val Tyr Ile Tyr Thr
         330                 335                 340

 ttt ggt aag gag cca acc tta aat aaa gtc cta gat gct tgt gat ggg     1290
 Phe Gly Lys Glu Pro Thr Leu Asn Lys Val Leu Asp Ala Cys Asp Gly
     345                 350                 355

 aaa ttt cag gca att gac ttt atc aca cct gga acc caa tac ttc atg     1338
 Lys Phe Gln Ala Ile Asp Phe Ile Thr Pro Gly Thr Gln Tyr Phe Met
 360                 365                 370                 375

 aca ctt aca tat tca ggg gaa att tgt gtt tgg tgg ctg gag gat tgt     1386
 Thr Leu Thr Tyr Ser Gly Glu Ile Cys Val Trp Trp Leu Glu Asp Cys
                 380                 385                 390

 gct tgt gta agc aag att tat ctg aat acc cta gca acg gtt ctg gct     1434
 Ala Cys Val Ser Lys Ile Tyr Leu Asn Thr Leu Ala Thr Val Leu Ala
             395                 400                 405

 tgc tgt cca tcc tcc ctc tct gca gcc gtg ggc acg gag gat ggc tcg     1482
 Cys Cys Pro Ser Ser Leu Ser Ala Ala Val Gly Thr Glu Asp Gly Ser
         410                 415                 420

 gtc tac ttc atc agc gta tat gat aag gaa tcc cct cag gtc gtg cac     1530
 Val Tyr Phe Ile Ser Val Tyr Asp Lys Glu Ser Pro Gln Val Val His
     425                 430                 435

 aag gcc ttt ctc tcg gaa tcg tcc gtg cag cac gtc gtt tat gat cag     1578
 Lys Ala Phe Leu Ser Glu Ser Ser Val Gln His Val Val Tyr Asp Gln
 440                 445                 450                 455

 caa gga ata ttt ctg tta gtt gga aca gca gaa gga aaa gtc ttt att     1626
 Gln Gly Ile Phe Leu Leu Val Gly Thr Ala Glu Gly Lys Val Phe Ile
                 460                 465                 470

 atc aat gcc aac tcc tca agc tca ttt cag att att gga ttc aca gag     1674
 Ile Asn Ala Asn Ser Ser Ser Ser Phe Gln Ile Ile Gly Phe Thr Glu
             475                 480                 485

 gtg gcc aaa gac att tta cag ata tcc aca gtg tct ctt tta gaa aca     1722
 Val Ala Lys Asp Ile Leu Gln Ile Ser Thr Val Ser Leu Leu Glu Thr
         490                 495                 500

 gac ata gtg gaa gtg atg gtg ctt tcc tcg ctt cca gaa gca ggg aga     1770
 Asp Ile Val Glu Val Met Val Leu Ser Ser Leu Pro Glu Ala Gly Arg
     505                 510                 515

 agc agg ttg gag atg ttc aca ctg cct aca tta ctg cca caa gtt tcc     1818
 Ser Arg Leu Glu Met Phe Thr Leu Pro Thr Leu Leu Pro Gln Val Ser
 520                 525                 530                 535

 aca acc ttt gct gat gaa aga gga agg ctg aaa gat gaa atc att cat     1866
 Thr Thr Phe Ala Asp Glu Arg Gly Arg Leu Lys Asp Glu Ile Ile His
                 540                 545                 550

 aag tac ctg tat gag ttg gag cac gct ctg tcc tct gca gtc ttg ggc     1914
 Lys Tyr Leu Tyr Glu Leu Glu His Ala Leu Ser Ser Ala Val Leu Gly
             555                 560                 565

 ttt caa agt aac caa ata tat ggc ttc tgt agt caa gtg cca tac atc     1962
 Phe Gln Ser Asn Gln Ile Tyr Gly Phe Cys Ser Gln Val Pro Tyr Ile
         570                 575                 580

 tgt agc tac ctt ctt cct gaa gaa gaa cat acc ggt atc tac att ctt     2010
 Cys Ser Tyr Leu Leu Pro Glu Glu Glu His Thr Gly Ile Tyr Ile Leu
     585                 590                 595

 aaa cca tac aaa aaa gta caa agc aga cag tat gga cct gga ctg ctc     2058
 Lys Pro Tyr Lys Lys Val Gln Ser Arg Gln Tyr Gly Pro Gly Leu Leu
 600                 605                 610                 615

 tat ctg tct tca cat gga ttg tgg ctc ata aca ata gct aaa tgt gga     2106
 Tyr Leu Ser Ser His Gly Leu Trp Leu Ile Thr Ile Ala Lys Cys Gly
                 620                 625                 630

 att ctg tgt atc cga gac gtt tat act ttg ggt cat ggg att cag tca     2154
 Ile Leu Cys Ile Arg Asp Val Tyr Thr Leu Gly His Gly Ile Gln Ser
             635                 640                 645

 atg aga att tca atg gat gga caa aac att ctg gtg aat ggg aga gat     2202
 Met Arg Ile Ser Met Asp Gly Gln Asn Ile Leu Val Asn Gly Arg Asp
         650                 655                 660

 gat ggc acc ctt gtc tac cta aag tgg aag tac gta cag tat tca aca     2250
 Asp Gly Thr Leu Val Tyr Leu Lys Trp Lys Tyr Val Gln Tyr Ser Thr
     665                 670                 675

 tgt ctg tct ttt tct acc atg tat cag aaa cag aag gca agc act gac     2298
 Cys Leu Ser Phe Ser Thr Met Tyr Gln Lys Gln Lys Ala Ser Thr Asp
 680                 685                 690                 695

 tta tca caa gat gaa tta gtt cta acc gat gtt aag aag gaa att cct     2346
 Leu Ser Gln Asp Glu Leu Val Leu Thr Asp Val Lys Lys Glu Ile Pro
                 700                 705                 710

 tgg ata caa caa aaa agc caa gag gta ttt gtg aaa cat ggg gta ggt     2394
 Trp Ile Gln Gln Lys Ser Gln Glu Val Phe Val Lys His Gly Val Gly
             715                 720                 725

 ttg aaa tag                                                         2403
 Leu Lys 






      <210> 236
      <211> 948
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(948)

      <400> 236
 cggtgagcgc ggcccgggcc ggac   atg gcg gcg ctc tac gcc tgc acc aag      51
                              Met Ala Ala Leu Tyr Ala Cys Thr Lys
                                1               5

 tgc cac cag cgc ttc ccc ttc gag gcg ctg tct cag ggg cag cag ctg       99
 Cys His Gln Arg Phe Pro Phe Glu Ala Leu Ser Gln Gly Gln Gln Leu
  10                  15                  20                  25

 tgc aag gaa tgt cgg att gca cac cct gtt gtg aag tgc acc tac tgc      147
 Cys Lys Glu Cys Arg Ile Ala His Pro Val Val Lys Cys Thr Tyr Cys
                  30                  35                  40

 agg act gag tac cag cag gag agt aaa acc aat aca ata tgc aag aaa      195
 Arg Thr Glu Tyr Gln Gln Glu Ser Lys Thr Asn Thr Ile Cys Lys Lys
              45                  50                  55

 tgt gct cag aac gtg cag ttg tat gga acg ccc aaa cct tgt cag tat      243
 Cys Ala Gln Asn Val Gln Leu Tyr Gly Thr Pro Lys Pro Cys Gln Tyr
          60                  65                  70

 tgc aac ata att gca gca ttt att ggg aat aaa tgc cag cgc tgc aca      291
 Cys Asn Ile Ile Ala Ala Phe Ile Gly Asn Lys Cys Gln Arg Cys Thr
      75                  80                  85

 aat tca gaa aag aag tat gga cca ccc tat tct tgt gaa cag tgc aag      339
 Asn Ser Glu Lys Lys Tyr Gly Pro Pro Tyr Ser Cys Glu Gln Cys Lys
  90                  95                 100                 105

 cag cag tgt gca ttt gac agg aaa gat gat aga aag aag gta gat ggg      387
 Gln Gln Cys Ala Phe Asp Arg Lys Asp Asp Arg Lys Lys Val Asp Gly
                 110                 115                 120

 aaa ttg ctg tgc tgg ctg tgc aca ctt tca tac aaa cgg gtc ctt cag      435
 Lys Leu Leu Cys Trp Leu Cys Thr Leu Ser Tyr Lys Arg Val Leu Gln
             125                 130                 135

 aag acc aaa gag cag agg aaa cac ctg agt agc tct tct cgt gct ggc      483
 Lys Thr Lys Glu Gln Arg Lys His Leu Ser Ser Ser Ser Arg Ala Gly
         140                 145                 150

 cac cag gag aag gag cag tat agt cgc ctg agt ggg ggg ggc cat tat      531
 His Gln Glu Lys Glu Gln Tyr Ser Arg Leu Ser Gly Gly Gly His Tyr
     155                 160                 165

 aac agc cag aaa aca ctt tct aca tct tca att caa aat gaa atc cca      579
 Asn Ser Gln Lys Thr Leu Ser Thr Ser Ser Ile Gln Asn Glu Ile Pro
 170                 175                 180                 185

 aag aaa aag tcc aag ttt gag tca atc aca act aat gga gac agc ttc      627
 Lys Lys Lys Ser Lys Phe Glu Ser Ile Thr Thr Asn Gly Asp Ser Phe
                 190                 195                 200

 tcc cca gac ctg gct ctg gac tca cca ggc act gac cac ttt gtc atc      675
 Ser Pro Asp Leu Ala Leu Asp Ser Pro Gly Thr Asp His Phe Val Ile
             205                 210                 215

 att gcc caa ctg aag gaa gaa gtg gct acc ctg aag aag atg ttg cat      723
 Ile Ala Gln Leu Lys Glu Glu Val Ala Thr Leu Lys Lys Met Leu His
         220                 225                 230

 caa aag gat caa atg att tta gag aaa gag aag aag att aca gag ttg      771
 Gln Lys Asp Gln Met Ile Leu Glu Lys Glu Lys Lys Ile Thr Glu Leu
     235                 240                 245

 aag gct gat ttt cag tac cag gaa tcg cag atg aga gcc aaa atg aac      819
 Lys Ala Asp Phe Gln Tyr Gln Glu Ser Gln Met Arg Ala Lys Met Asn
 250                 255                 260                 265

 cag atg gag aaa acc cac aaa gaa gtc aca gaa caa ctg cag gcc aaa      867
 Gln Met Glu Lys Thr His Lys Glu Val Thr Glu Gln Leu Gln Ala Lys
                 270                 275                 280

 aac cga gag ctc ctg aag cag gca gct gct ttg tcc aag agc aag aag      915
 Asn Arg Glu Leu Leu Lys Gln Ala Ala Ala Leu Ser Lys Ser Lys Lys
             285                 290                 295

 tca gag aag tca gga gct ata acc tct cca tga                          948
 Ser Glu Lys Ser Gly Ala Ile Thr Ser Pro 
         300                 305





      <210> 237
      <211> 700
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(550)

      <400> 237
 cctcgagatc cctagtcagt gtcgtggaat tcgtgacgta tgacacaaga aagtactgtg     60

 catgtcgtag catcagggag ggccccaggg atctgggctg gtctggctgt tgagagggcc    120

 actagggaga cttttgtgat caggt  atg ccc ctg tgg gca tcc cag aac ccc     172
                              Met Pro Leu Trp Ala Ser Gln Asn Pro
                                1               5

 tta tcc ctt tcc aca gga gcc atg tgt gag ata cct gcc cag gct gta      220
 Leu Ser Leu Ser Thr Gly Ala Met Cys Glu Ile Pro Ala Gln Ala Val
  10                  15                  20                  25

 cct gga cat aca cgt aag agg gtt ctc cct ggg gga ggg agg tct tgg      268
 Pro Gly His Thr Arg Lys Arg Val Leu Pro Gly Gly Gly Arg Ser Trp
                  30                  35                  40

 gct gag gga ctc agg tct gaa cct ctg ctg ctg gct gtg tgg cac aga      316
 Ala Glu Gly Leu Arg Ser Glu Pro Leu Leu Leu Ala Val Trp His Arg
              45                  50                  55

 gtc agg gag aga tct tat gca gct cag tcc ctg ttc ctc ttg cta ctg      364
 Val Arg Glu Arg Ser Tyr Ala Ala Gln Ser Leu Phe Leu Leu Leu Leu
          60                  65                  70

 act tct ccc aca agc ccc ctc ccc att gtc cac tcc cag aat tac tgt      412
 Thr Ser Pro Thr Ser Pro Leu Pro Ile Val His Ser Gln Asn Tyr Cys
      75                  80                  85

 gtg ctg gac aag ctg cgg gac ttt gtg gcc tcg ccc ccg tgt tgg aaa      460
 Val Leu Asp Lys Leu Arg Asp Phe Val Ala Ser Pro Pro Cys Trp Lys
  90                  95                 100                 105

 gtg gcc cag gta gat tcc ttg aag gac aaa gca cgg aag ctg tac acc      508
 Val Ala Gln Val Asp Ser Leu Lys Asp Lys Ala Arg Lys Leu Tyr Thr
                 110                 115                 120

 atc atg aac tcg ttc tgc agg aga gta agt gga tgc cat tga aagtcta      557
 Ile Met Asn Ser Phe Cys Arg Arg Val Ser Gly Cys His 
             125                 130

 ttttctactt gctatcagcc aagactttct gagcttttca aagaggagag ttgggaggag    617

 atggtgacaa ggaagaggag cagagatgtt tcgcagatgc tttcagttca caaagccctt    677

 tctcaaccat ggttgccttg ttg                                            700




      <210> 238
      <211> 700
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(550)

      <400> 238
 cctcgagatc cctagtcagt gtcgtggaat tcgtgacgta tgacacaaga aagtactgtg     60

 catgtcgtag catcagggag ggccccaggg atctgggctg gtctggctgt tgagagggcc    120

 actagggaga cttttgtgat caggt  atg ccc ctg tgg gca tcc cag aac ccc     172
                              Met Pro Leu Trp Ala Ser Gln Asn Pro
                                1               5

 tta tcc ctt tcc aca gga gcc atg tgt gag ata cct gcc cag gct gta      220
 Leu Ser Leu Ser Thr Gly Ala Met Cys Glu Ile Pro Ala Gln Ala Val
  10                  15                  20                  25

 cct gga cat aca cgt aag agg gtt ctc cct ggg gga ggg agg tct tgg      268
 Pro Gly His Thr Arg Lys Arg Val Leu Pro Gly Gly Gly Arg Ser Trp
                  30                  35                  40

 gct gag gga ctc agg tct gaa cct ctg ctg ctg gct gtg tgg cac aga      316
 Ala Glu Gly Leu Arg Ser Glu Pro Leu Leu Leu Ala Val Trp His Arg
              45                  50                  55

 gtc agg gag aga tct tat gca gct cag tcc ctg ttc ctc ttg cta ctg      364
 Val Arg Glu Arg Ser Tyr Ala Ala Gln Ser Leu Phe Leu Leu Leu Leu
          60                  65                  70

 act tct ccc aca agc ccc ctc ccc att gtc cac tcc cag aat tac tgt      412
 Thr Ser Pro Thr Ser Pro Leu Pro Ile Val His Ser Gln Asn Tyr Cys
      75                  80                  85

 gtg ctg gac aag ctg cgg gac ttt gtg gcc tcg ccc ccg tgt tgg aaa      460
 Val Leu Asp Lys Leu Arg Asp Phe Val Ala Ser Pro Pro Cys Trp Lys
  90                  95                 100                 105

 gtg gcc cag gta gat tcc ttg aag gac aaa gca cgg aag ctg tac acc      508
 Val Ala Gln Val Asp Ser Leu Lys Asp Lys Ala Arg Lys Leu Tyr Thr
                 110                 115                 120

 atc atg aac tcg ttc tgc agg aga gta agt gga tgc cat tga aagtcta      557
 Ile Met Asn Ser Phe Cys Arg Arg Val Ser Gly Cys His 
             125                 130

 ttttctactt gctatcagcc aagactttct gagcttttca aagaggagag ttgggaggag    617

 atggtgacaa ggaagaggag cagagatgtt tcgcagatgc tttcagttca caaagccctt    677

 tctcaaccat ggttgccttg ttg                                            700




      <210> 239
      <211> 870
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(616)

      <220>
      <221> misc_feature
      <222> (1)...(870)
      <223> n = a,t,c or g

      <400> 239
 cctcgagatc cctagtcagt gtcgtggaat tcgtgacgta tgacacaaga aagtactgtg     60

 catgtcgtag catcagggag ggccccaggg atctgggctg gtctggctgt tgagagggcc    120

 actagggaga cttttgtgat caggt  atg ccc ctg tgg gca tcc cag aac ccc     172
                              Met Pro Leu Trp Ala Ser Gln Asn Pro
                                1               5

 tta tcc ctt tcc aca gga gcc atg tgt gag ata cct gcc cag gct gta      220
 Leu Ser Leu Ser Thr Gly Ala Met Cys Glu Ile Pro Ala Gln Ala Val
  10                  15                  20                  25

 cct gga cat aca cgt aag agg gtt ctc cct ggg gga ggg agg tct tgg      268
 Pro Gly His Thr Arg Lys Arg Val Leu Pro Gly Gly Gly Arg Ser Trp
                  30                  35                  40

 gct gag gga ctc agg tct gaa cct ctg ctg ctg gct gtg tgg cac aga      316
 Ala Glu Gly Leu Arg Ser Glu Pro Leu Leu Leu Ala Val Trp His Arg
              45                  50                  55

 gtc agg gag aga tct tat gca gct cag tcc ctg ttc ctc ttg cta ctg      364
 Val Arg Glu Arg Ser Tyr Ala Ala Gln Ser Leu Phe Leu Leu Leu Leu
          60                  65                  70

 act tct ccc aca agc ccc ctc ccc att gtc cac tcc cag aat tac tgt      412
 Thr Ser Pro Thr Ser Pro Leu Pro Ile Val His Ser Gln Asn Tyr Cys
      75                  80                  85

 gtg ctg gac aag ctg cgg gac ttt gtg gcc tcg ccc ccg tgt tgg aaa      460
 Val Leu Asp Lys Leu Arg Asp Phe Val Ala Ser Pro Pro Cys Trp Lys
  90                  95                 100                 105

 gtg gcc cag gta gat tcc ttg aag gac aaa gca cgg aag ctg tac acc      508
 Val Ala Gln Val Asp Ser Leu Lys Asp Lys Ala Arg Lys Leu Tyr Thr
                 110                 115                 120

 atc atg aac tcg ttc tgc agg aga gat ttg gta ttc ctg ttg gat gac      556
 Ile Met Asn Ser Phe Cys Arg Arg Asp Leu Val Phe Leu Leu Asp Asp
             125                 130                 135

 tgc aat gcc ttg gaa tac cca atc cca gtg act acg gtc ctg cca gat      604
 Cys Asn Ala Leu Glu Tyr Pro Ile Pro Val Thr Thr Val Leu Pro Asp
         140                 145                 150

 cgt cag cgc taa ggg aactgagacc agagaaagaa cccaagagaa ctaaagttat      659
 Arg Gln Arg 
     155

 gtcagctacc cagacttaat gggccagagc catgaccctc acaggtcttg tgttagttgt    719

 atctgaaact gttatgtatc tctctacctt ctggaaaaca gggctggtat tcctacccag    779

 gaacctcctt ttgaggcata ggagttaggc aaccatggnt tctnatttcc cttgaantca    839

 tgtctttncc agggttggtt taggattaca c                                   870




      <210> 240
      <211> 821
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(242)

      <400> 240
 gcacc    atg agg acg cct ggg cct ctg ccc gtg ctg ctg ctg ctc ctg      47
          Met Arg Thr Pro Gly Pro Leu Pro Val Leu Leu Leu Leu Leu
            1               5                  10

 gcg gga gcc ccc gcc gcg cgg ccc act ccc ccg acc tgc tac tcc cgc       95
 Ala Gly Ala Pro Ala Ala Arg Pro Thr Pro Pro Thr Cys Tyr Ser Arg
  15                  20                  25                  30

 atg cgg gcc ctg agc cag gag atc acc cgc gac ttc aac ctc ctg cag      143
 Met Arg Ala Leu Ser Gln Glu Ile Thr Arg Asp Phe Asn Leu Leu Gln
                  35                  40                  45

 gtc tcg gag ccc tcg gat ttg gta ttc ctg ttg gat gac tgc aat gcc      191
 Val Ser Glu Pro Ser Asp Leu Val Phe Leu Leu Asp Asp Cys Asn Ala
              50                  55                  60

 ttg gaa tac cca atc cca gtg act acg gtc ctg cca gat cgt cag cgc      239
 Leu Glu Tyr Pro Ile Pro Val Thr Thr Val Leu Pro Asp Arg Gln Arg
          65                  70                  75

 taa ggga actgagacca gagaaagaac ccaagagaac taaagttatg tcagctaccc      296
 


 agacttaatg ggccagagcc atgaccctca caggtcttgt gttagttgta tctgaaactg    356

 ttatgtatct ctctaccttc tggaaaacag ggctggtatt cctacccagg aacctccttt    416

 gagcatagag ttagcaacca tgcttctcat tcccttgact catgtcttgc caggatggtt    476

 agatacacag catgttgatt tggtcactaa aaagaagaaa aggactaaca agcttcactt    536

 ttatgaacaa ctattttgag aacatgcaca atagtaagtt tttattactg gtttaatgga    596

 gtaatggtac ttttattctt tcttgataga aacctgctta catttaacca agcttctatt    656

 atgccttttt ctaacacaga ctttcttcac tgtctttcat ttaaaaagaa attaatgctc    716

 ttaagatata tattttacgt agtgctgaca ggacccactc tttcattgaa aggtgatgaa    776

 aatcaaataa agaatctctt cacatgagaa aaaaaaaaaa aaaaa                    821




      <210> 241
      <211> 947
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(434)

      <400> 241
 gcacc    atg agg acg cct ggg cct ctg ccc gtg ctg ctg ctg ctc ctg      47
          Met Arg Thr Pro Gly Pro Leu Pro Val Leu Leu Leu Leu Leu
            1               5                  10

 gcg gga gcc ccc gcc gcg cgg ccc act ccc ccg acc tgc tac tcc cgc       95
 Ala Gly Ala Pro Ala Ala Arg Pro Thr Pro Pro Thr Cys Tyr Ser Arg
  15                  20                  25                  30

 atg cgg gcc ctg agc cag gag atc acc cgc gac ttc aac ctc ctg cag      143
 Met Arg Ala Leu Ser Gln Glu Ile Thr Arg Asp Phe Asn Leu Leu Gln
                  35                  40                  45

 gtc tcg gag ccc tcg gag cca tgt gtg aga tac ctg ccc agg ctg tac      191
 Val Ser Glu Pro Ser Glu Pro Cys Val Arg Tyr Leu Pro Arg Leu Tyr
              50                  55                  60

 ctg gac ata cac aat tac tgt gtg ctg gac aag ctg cgg gac ttt gtg      239
 Leu Asp Ile His Asn Tyr Cys Val Leu Asp Lys Leu Arg Asp Phe Val
          65                  70                  75

 gcc tcg ccc ccg tgt tgg aaa gtg gcc cag gta gat tcc ttg aag gac      287
 Ala Ser Pro Pro Cys Trp Lys Val Ala Gln Val Asp Ser Leu Lys Asp
      80                  85                  90

 aaa gca cgg aag ctg tac acc atc atg aac tcg ttc tgc agg aga gat      335
 Lys Ala Arg Lys Leu Tyr Thr Ile Met Asn Ser Phe Cys Arg Arg Asp
  95                 100                 105                 110

 ttg gat gac tac ggt cct gcc aga tcg tca gcg cta agg gaa ctg aga      383
 Leu Asp Asp Tyr Gly Pro Ala Arg Ser Ser Ala Leu Arg Glu Leu Arg
                 115                 120                 125

 cca gag aaa gaa ccc aag aga act aaa gtt atg tca gct acc cag act      431
 Pro Glu Lys Glu Pro Lys Arg Thr Lys Val Met Ser Ala Thr Gln Thr
             130                 135                 140

 taa tggg ccagagccat gaccctcaca ggtcttgtgt tagttgtatc tgaaactgtt      488
 


 atgtatctct ctaccttctg gaaaacaggg ctggtattcc tacccaggaa cctcctttga    548

 gcatagagtt agcaaccatg cttctcattc ccttgactca tgtcttgcca ggatggttag    608

 atacacagca tgttgatttg gtcactaaaa agaagaaaag gactaacaag cttcactttt    668

 atgaacaact attttgagaa catgcacaat agtatgtttt tattactggt ttaatggagt    728

 aatggtactt ttattctttc ttgatagaaa cctgcttaca tttaaccaag cttctattat    788

 gcctttttct aacacagact ttcttcactg tctttcattt aaaaagaaat taatgctctt    848

 aagatatata ttttacgtag tgctgacagg acccactctt tcattgaaag gtgatgaaaa    908

 tcaaataaag aatctcttcc ccttaaaaaa aaaaaaaaa                           947




      <210> 242
      <211> 2067
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (240)..(1817)

      <220>
      <221> misc_feature
      <222> (1)...(2067)
      <223> n = a,t,c or g

      <400> 242
 cggaatggac tgtccgggtc gacgatttcg tctccgccag acctgctgcc agcttgcccg     60

 gtccagccct gagagagcct cgaacgccag ctgcgagggt catgagccag agagccccgg    120

 ggcgccgcgc ggagagcaag cggagatagc gactttgcgc cccccagccc tcgccttctt    180

 gcatcgcgtt ccccgcatcc tcgggtcctt ctgtcctttc cgctgtcccc accgccgcc     239                                                                 
 atg gcc acc ttg ctc cgc agc aag ctg tcc aac gtg gcc acg tcc gtg      287
 Met Ala Thr Leu Leu Arg Ser Lys Leu Ser Asn Val Ala Thr Ser Val
   1               5                  10                  15

 tcc aac aag tcc cag gcc aag atg agc ggc atg ttc gcc agg atg ggt      335
 Ser Asn Lys Ser Gln Ala Lys Met Ser Gly Met Phe Ala Arg Met Gly
              20                  25                  30

 ttt cag gcg gcc acg gat gag gag gcg gtg ggc ttc gcg cat tgc gac      383
 Phe Gln Ala Ala Thr Asp Glu Glu Ala Val Gly Phe Ala His Cys Asp
          35                  40                  45

 gac ctc gac ttt gag cac cgc cag ggc ctg cag atg gac atc ctg aaa      431
 Asp Leu Asp Phe Glu His Arg Gln Gly Leu Gln Met Asp Ile Leu Lys
      50                  55                  60

 gcc gag gga gag ccc tgc ggg gac gag ggc gct gaa gcg cac gtc gag      479
 Ala Glu Gly Glu Pro Cys Gly Asp Glu Gly Ala Glu Ala His Val Glu
  65                  70                  75                  80

 gga gac atc cat tat cag cga ggc agc gga gct cct ctg ccg ccc tcc      527
 Gly Asp Ile His Tyr Gln Arg Gly Ser Gly Ala Pro Leu Pro Pro Ser
                  85                  90                  95

 ggc tcc aag gac cag gtg gga ggt ggt ggc gaa ttc ggg ggc cac gac      575
 Gly Ser Lys Asp Gln Val Gly Gly Gly Gly Glu Phe Gly Gly His Asp
             100                 105                 110

 aag ccc aaa atc acg gcg tgg gag gca ggc tgg aac gtg acc aac gcc      623
 Lys Pro Lys Ile Thr Ala Trp Glu Ala Gly Trp Asn Val Thr Asn Ala
         115                 120                 125

 atc cag ggc atg ttc gtg ctg ggc cta ccc tac gcc atc ctg cac ggc      671
 Ile Gln Gly Met Phe Val Leu Gly Leu Pro Tyr Ala Ile Leu His Gly
     130                 135                 140

 ggc tac ctg ggg ttg ttt ctc atc atc ttc gcc gcc gtt gtg tgc tgc      719
 Gly Tyr Leu Gly Leu Phe Leu Ile Ile Phe Ala Ala Val Val Cys Cys
 145                 150                 155                 160

 tac acc ggc aag atc ctc atc gcg tgc ctg tac gag gag aat gaa gac      767
 Tyr Thr Gly Lys Ile Leu Ile Ala Cys Leu Tyr Glu Glu Asn Glu Asp
                 165                 170                 175

 ggc gag gtg gtg cgc gtg cgg gac tcg tac gtg gcc ata gcc aac gcc      815
 Gly Glu Val Val Arg Val Arg Asp Ser Tyr Val Ala Ile Ala Asn Ala
             180                 185                 190

 tgc tgc gcc ccg cgc ttc cca acg ctg ggc ggc cga gtg gtg aac gta      863
 Cys Cys Ala Pro Arg Phe Pro Thr Leu Gly Gly Arg Val Val Asn Val
         195                 200                 205

 gcg cag atc atc gag ctg gtg atg acg tgc atc ctg tac gtg gtg gtg      911
 Ala Gln Ile Ile Glu Leu Val Met Thr Cys Ile Leu Tyr Val Val Val
     210                 215                 220

 agt ggc aac ctc atg tac aac agc ttc ccg ggg ctg ccc gtg tcg cag      959
 Ser Gly Asn Leu Met Tyr Asn Ser Phe Pro Gly Leu Pro Val Ser Gln
 225                 230                 235                 240

 aag tcc tgg tcc att atc gcc acg gcc gtg ctg ctg cct tgc gcc ttc     1007
 Lys Ser Trp Ser Ile Ile Ala Thr Ala Val Leu Leu Pro Cys Ala Phe
                 245                 250                 255

 ctt aag aac ctc aag gcc gtg tcc aag ttc agt ctg ctg tgc act ctg     1055
 Leu Lys Asn Leu Lys Ala Val Ser Lys Phe Ser Leu Leu Cys Thr Leu
             260                 265                 270

 gcc cac ttc gtc atc aat atc ctg gtc ata gcc tac tgt cta tcg cgg     1103
 Ala His Phe Val Ile Asn Ile Leu Val Ile Ala Tyr Cys Leu Ser Arg
         275                 280                 285

 gcg cgc gac tgg gcc tgg gag aag gtc aag ttc tac atc gac gtc aag     1151
 Ala Arg Asp Trp Ala Trp Glu Lys Val Lys Phe Tyr Ile Asp Val Lys
     290                 295                 300

 aag ttc ccc atc tcc att ggc atc atc gtg ttc agc tac acg tct cag     1199
 Lys Phe Pro Ile Ser Ile Gly Ile Ile Val Phe Ser Tyr Thr Ser Gln
 305                 310                 315                 320

 atc ttc ctg cct tcg ctg gag ggc aat atg cag cag ccc agc gag ttc     1247
 Ile Phe Leu Pro Ser Leu Glu Gly Asn Met Gln Gln Pro Ser Glu Phe
                 325                 330                 335

 cac tgc atg atg aac tgg acg cac atc gca gcc tgc gtg ctc aag ggc     1295
 His Cys Met Met Asn Trp Thr His Ile Ala Ala Cys Val Leu Lys Gly
             340                 345                 350

 ctc ttc gcg ctc gtc gcc tac ctc acc tgg gcc gac gag acc aag gag     1343
 Leu Phe Ala Leu Val Ala Tyr Leu Thr Trp Ala Asp Glu Thr Lys Glu
         355                 360                 365

 gtc atc acg gat aac ctg ccc ggc tcc atc cgc gcc gtg gtc aac atc     1391
 Val Ile Thr Asp Asn Leu Pro Gly Ser Ile Arg Ala Val Val Asn Ile
     370                 375                 380

 ttt ctg gtg gcc aag gcg ctg ttg tcc tat cct ctg cca ttc ttt gcc     1439
 Phe Leu Val Ala Lys Ala Leu Leu Ser Tyr Pro Leu Pro Phe Phe Ala
 385                 390                 395                 400

 gct gtc gag gtg ctg gag aag tcg ctc ttc cag gaa ggc agc cgc gcc     1487
 Ala Val Glu Val Leu Glu Lys Ser Leu Phe Gln Glu Gly Ser Arg Ala
                 405                 410                 415

 ttt ttc ccg gcc tgc tac agc ggc gac ggg cgc ctg aag tcc tgg ggg     1535
 Phe Phe Pro Ala Cys Tyr Ser Gly Asp Gly Arg Leu Lys Ser Trp Gly
             420                 425                 430

 ctg acg ctg cgc tgc gcg ctc gtc gtc ttc acg ctg ctc atg gcc att     1583
 Leu Thr Leu Arg Cys Ala Leu Val Val Phe Thr Leu Leu Met Ala Ile
         435                 440                 445

 tat gtg ccg cac ttc gcg ctg ctc atg ggc ctc acc ggc agc ctc acg     1631
 Tyr Val Pro His Phe Ala Leu Leu Met Gly Leu Thr Gly Ser Leu Thr
     450                 455                 460

 ggc gcc ggc ctc tgt ttc ttg ctg ccc agc ctc ttt cac ctg cgc ctg     1679
 Gly Ala Gly Leu Cys Phe Leu Leu Pro Ser Leu Phe His Leu Arg Leu
 465                 470                 475                 480

 ctc tgg cgc aag ctg ctg tgg cac caa gtc ttc ttc gac gtc gcc atc     1727
 Leu Trp Arg Lys Leu Leu Trp His Gln Val Phe Phe Asp Val Ala Ile
                 485                 490                 495

 ttc gtc atc ggc ggc atc tgc agc gtg tcc ggc ttc gtg cac tcc ctc     1775
 Phe Val Ile Gly Gly Ile Cys Ser Val Ser Gly Phe Val His Ser Leu
             500                 505                 510

 gag ggc ctc atc gaa gcc tac cga acc aac gcg gag gac tag ggcgcaa     1824
 Glu Gly Leu Ile Glu Ala Tyr Arg Thr Asn Ala Glu Asp 
         515                 520                 525

 gggcgagccc ccgccgcgct tctgcgctct ctcccttctc ccctcacccc gcccccacca   1884

 gcccagtgcg ccctgccgcc gcgcttggga ggccaagctt taaacatctc tggttcctag   1944

 tttctgatta ttcggggatg ggggggatgg gaggggacag ggattcacga tccatcgcgt   2004

 ctgcgtttct gttgtccttt cttttccaca acaccctggg tttgggggga ggcggngtgc   2064

 att                                                                 2067




      <210> 243
      <211> 1439
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (98)..(1249)

      <400> 243
 gcggagggcg aggaggagca gaggagcaca cagatgaagc aggtgtccac gcgtccggcc     60

 gtccatccgt ccgtccctcc tggggccggc gctgacc atg ccc agc ggc tgc cgc     115
                                          Met Pro Ser Gly Cys Arg
                                            1               5

 tgc ctg cat ctc gtg tgc ctg ttg tgc att ctg ggg gct ccc ggt cag      163
 Cys Leu His Leu Val Cys Leu Leu Cys Ile Leu Gly Ala Pro Gly Gln
              10                  15                  20

 cct gtc cga gcc gat gac tgc agc tcc cac tgt gac ctg gcc cac ggc      211
 Pro Val Arg Ala Asp Asp Cys Ser Ser His Cys Asp Leu Ala His Gly
          25                  30                  35

 tgc tgt gca cct gac ggc tcc tgc agg tgt gac ccg ggc tgg gag ggg      259
 Cys Cys Ala Pro Asp Gly Ser Cys Arg Cys Asp Pro Gly Trp Glu Gly
      40                  45                  50

 ctg cac tgt gag cgc tgt gtg agg atg cct ggc tgc cag cac ggt acc      307
 Leu His Cys Glu Arg Cys Val Arg Met Pro Gly Cys Gln His Gly Thr
  55                  60                  65                  70

 tgc cac cag cca tgg cag tgc atc tgc cac agt ggc tgg gca ggc aag      355
 Cys His Gln Pro Trp Gln Cys Ile Cys His Ser Gly Trp Ala Gly Lys
                  75                  80                  85

 ttc tgt gac aaa gat gaa cat atc tgt acc acg cag tcc ccc tgc cag      403
 Phe Cys Asp Lys Asp Glu His Ile Cys Thr Thr Gln Ser Pro Cys Gln
              90                  95                 100

 aat gga ggc cag tgc atg tat gac ggg ggc ggt gag tac cat tgt gtg      451
 Asn Gly Gly Gln Cys Met Tyr Asp Gly Gly Gly Glu Tyr His Cys Val
         105                 110                 115

 tgc tta cca ggc ttc cat ggg cgt gac tgc gag cgc aag gct gga ccc      499
 Cys Leu Pro Gly Phe His Gly Arg Asp Cys Glu Arg Lys Ala Gly Pro
     120                 125                 130

 tgt gaa cag gca ggc tcc cca tgc cgc aat ggc ggg cag tgc cag gac      547
 Cys Glu Gln Ala Gly Ser Pro Cys Arg Asn Gly Gly Gln Cys Gln Asp
 135                 140                 145                 150

 gac cag ggc ttt gct ctc aac ttc acg tgc cgc tgc ttg gtg ggc ttt      595
 Asp Gln Gly Phe Ala Leu Asn Phe Thr Cys Arg Cys Leu Val Gly Phe
                 155                 160                 165

 gtg ggt gcc cgc tgt gag gta aat gtg gat gac tgc ctg atg cgg cct      643
 Val Gly Ala Arg Cys Glu Val Asn Val Asp Asp Cys Leu Met Arg Pro
             170                 175                 180

 tgt gct aac ggt gcc acc tgc ctt gac ggc ata aac cgc ttc tcc tgc      691
 Cys Ala Asn Gly Ala Thr Cys Leu Asp Gly Ile Asn Arg Phe Ser Cys
         185                 190                 195

 ctc tgt cct gag ggc ttt gct gga cgc ttc tgc acc atc aac ctg gat      739
 Leu Cys Pro Glu Gly Phe Ala Gly Arg Phe Cys Thr Ile Asn Leu Asp
     200                 205                 210

 gac tgt gcc agc cgc cca tgc cag aga ggg gcc cgc tgt cgg gac cgt      787
 Asp Cys Ala Ser Arg Pro Cys Gln Arg Gly Ala Arg Cys Arg Asp Arg
 215                 220                 225                 230

 gtc cac gac ttc gac tgc ctc tgc ccc agt ggc tat ggt ggc aag acc      835
 Val His Asp Phe Asp Cys Leu Cys Pro Ser Gly Tyr Gly Gly Lys Thr
                 235                 240                 245

 tgt gag ctt gtc tta cct gtc cca gac ccc cca acc aca gtg gac acc      883
 Cys Glu Leu Val Leu Pro Val Pro Asp Pro Pro Thr Thr Val Asp Thr
             250                 255                 260

 cct cta ggg ccc acc tca gct gta gtg gta cct gcc acg ggg cca gcc      931
 Pro Leu Gly Pro Thr Ser Ala Val Val Val Pro Ala Thr Gly Pro Ala
         265                 270                 275

 ccc cac agc gca ggg gct ggt ctg ctg cgg atc tca gtg aag gag gtg      979
 Pro His Ser Ala Gly Ala Gly Leu Leu Arg Ile Ser Val Lys Glu Val
     280                 285                 290

 gtg cgg agg caa gag gct ggg cta ggt gag cct agc ttg gtg gcc ctg     1027
 Val Arg Arg Gln Glu Ala Gly Leu Gly Glu Pro Ser Leu Val Ala Leu
 295                 300                 305                 310

 gtg gtg ttt ggg gcc ctc act gct gcc ctg gtt ctg gct act gtg ttg     1075
 Val Val Phe Gly Ala Leu Thr Ala Ala Leu Val Leu Ala Thr Val Leu
                 315                 320                 325

 ctg acc ctg agg gcc tgg cgc cgg ggt gtc tgc ccc cct gga ccc tgt     1123
 Leu Thr Leu Arg Ala Trp Arg Arg Gly Val Cys Pro Pro Gly Pro Cys
             330                 335                 340

 tgc tac cct gcc cca cac tat gct cca gcg tgc cag gac cag gag tgt     1171
 Cys Tyr Pro Ala Pro His Tyr Ala Pro Ala Cys Gln Asp Gln Glu Cys
         345                 350                 355

 cag gtt agc atg ctg cca gca ggg ctc ccc ctg cca cgt gac ttg ccc     1219
 Gln Val Ser Met Leu Pro Ala Gly Leu Pro Leu Pro Arg Asp Leu Pro
     360                 365                 370

 cct gag cct gga aag acc aca gca ctg tga t ggaggtgggg gctttctggc     1270
 Pro Glu Pro Gly Lys Thr Thr Ala Leu 
 375                 380

 ccccttcctc acctcttcca cccctcagac tggagtggtc cgttctcacc acccttcagc   1330

 ttgggtacac acacagagga gacctcagcc tcacaccaga aatattattt ttttaataca   1390

 cagaatgtaa gatggaattt tatcaaataa aactatgaaa atgcaaaaa               1439




      <210> 244
      <211> 1635
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1635)

      <400> 244
  atg tcg aag gcg gcc gga ggc gcg gcg gcg gct gcg gcg gcg gcg gaa      48
  Met Ser Lys Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Ala Ala Glu
    1               5                  10                  15

 agt tgt tcc cca gcc ccg gcc ggc tcg tcc gcg gcc ccg ccc gcg ccg       96
 Ser Cys Ser Pro Ala Pro Ala Gly Ser Ser Ala Ala Pro Pro Ala Pro
              20                  25                  30

 gtg gag gac ctg tcc aaa gtg tcg gac gag gag ctg ctg cag tgg agc      144
 Val Glu Asp Leu Ser Lys Val Ser Asp Glu Glu Leu Leu Gln Trp Ser
          35                  40                  45

 aag gag gag ctg atc cgc agc ctg cgg cgc gcc gag gcg gag aag gtg      192
 Lys Glu Glu Leu Ile Arg Ser Leu Arg Arg Ala Glu Ala Glu Lys Val
      50                  55                  60

 agc gcg atg ctg gac cac agc aac ctc atc cgc gag gtg aac cgc cgc      240
 Ser Ala Met Leu Asp His Ser Asn Leu Ile Arg Glu Val Asn Arg Arg
  65                  70                  75                  80

 ctg cag ctg cac ctc ggc gag atc cgc ggc ctc aag gtt gac tgg ggg      288
 Leu Gln Leu His Leu Gly Glu Ile Arg Gly Leu Lys Val Asp Trp Gly
                  85                  90                  95

 aaa gag gag gag caa aga gac tca gta tgg aag gag cag cat ttt gac      336
 Lys Glu Glu Glu Gln Arg Asp Ser Val Trp Lys Glu Gln His Phe Asp
             100                 105                 110

 aga gta ccc caa gtg ttg gaa gcc aga cac aaa cga aat cac tgc agg      384
 Arg Val Pro Gln Val Leu Glu Ala Arg His Lys Arg Asn His Cys Arg
         115                 120                 125

 gac ttc agg gag caa att ccc gaa ggc aca agc tgt tct ttt ccc ctt      432
 Asp Phe Arg Glu Gln Ile Pro Glu Gly Thr Ser Cys Ser Phe Pro Leu
     130                 135                 140

 tcc act cct atc ccc aca tat cag aca gta gat gct gtt ccg gaa ttg      480
 Ser Thr Pro Ile Pro Thr Tyr Gln Thr Val Asp Ala Val Pro Glu Leu
 145                 150                 155                 160

 cct cag tgc tcc agc tct ggg att ctg ggg caa gaa aga gtg gga aga      528
 Pro Gln Cys Ser Ser Ser Gly Ile Leu Gly Gln Glu Arg Val Gly Arg
                 165                 170                 175

 gtg gaa tgc tca agg ctc acc tat gtg ctg ggc cca gtt cag gat atc      576
 Val Glu Cys Ser Arg Leu Thr Tyr Val Leu Gly Pro Val Gln Asp Ile
             180                 185                 190

 aac cag aaa ctc cag gaa gac aac cag gaa ctg agg gac ctc tgc tgt      624
 Asn Gln Lys Leu Gln Glu Asp Asn Gln Glu Leu Arg Asp Leu Cys Cys
         195                 200                 205

 ttc ctg gat gat gac cgg cag aaa ggc aag agg gtg tct cgg gag tgg      672
 Phe Leu Asp Asp Asp Arg Gln Lys Gly Lys Arg Val Ser Arg Glu Trp
     210                 215                 220

 cag aga ctg ggt cgc tac act gcc ggg gtg atg cac aag gaa gtg gcc      720
 Gln Arg Leu Gly Arg Tyr Thr Ala Gly Val Met His Lys Glu Val Ala
 225                 230                 235                 240

 tta tac ctg cag aag ctg aaa gac ctg gag gtg aag cag gag gaa gtg      768
 Leu Tyr Leu Gln Lys Leu Lys Asp Leu Glu Val Lys Gln Glu Glu Val
                 245                 250                 255

 gtg aag gag aac atg gag ctc aag gag ctc tgt gtg cta cta gat gag      816
 Val Lys Glu Asn Met Glu Leu Lys Glu Leu Cys Val Leu Leu Asp Glu
             260                 265                 270

 gag aag ggt gca ggc tgc gca ggc agc cgc tgc tcc atc gac agc cag      864
 Glu Lys Gly Ala Gly Cys Ala Gly Ser Arg Cys Ser Ile Asp Ser Gln
         275                 280                 285

 gcc agc ctg tgc caa ctc aca gcc tcc acc gca ccc tac gtg cgg gat      912
 Ala Ser Leu Cys Gln Leu Thr Ala Ser Thr Ala Pro Tyr Val Arg Asp
     290                 295                 300

 gtg ggt gac ggc agc agc acc tcc agc act ggc agc act gac agc ccg      960
 Val Gly Asp Gly Ser Ser Thr Ser Ser Thr Gly Ser Thr Asp Ser Pro
 305                 310                 315                 320

 gac cac cac aag cac cac gcg agc agt ggc agc ccg gag cac ctg cag     1008
 Asp His His Lys His His Ala Ser Ser Gly Ser Pro Glu His Leu Gln
                 325                 330                 335

 aag ccc cgg agc gag ggc agc ccg gag cac tcc aag cac agg agc gcc     1056
 Lys Pro Arg Ser Glu Gly Ser Pro Glu His Ser Lys His Arg Ser Ala
             340                 345                 350

 agc ccc gag cat cca cag aaa ccc aga gcc tgt gga acc cca gat cgc     1104
 Ser Pro Glu His Pro Gln Lys Pro Arg Ala Cys Gly Thr Pro Asp Arg
         355                 360                 365

 ccc aaa gca ctc aaa gga cct agc ccg gag cac cac aaa ccc ttg tgc     1152
 Pro Lys Ala Leu Lys Gly Pro Ser Pro Glu His His Lys Pro Leu Cys
     370                 375                 380

 aag ggc agc ccc gaa cag caa agg cac ccg cat cca ggg agc agc ccc     1200
 Lys Gly Ser Pro Glu Gln Gln Arg His Pro His Pro Gly Ser Ser Pro
 385                 390                 395                 400

 gaa acg ctg ccc aag cac gtg ctg agt ggg agc ccg gaa cac ttc cag     1248
 Glu Thr Leu Pro Lys His Val Leu Ser Gly Ser Pro Glu His Phe Gln
                 405                 410                 415

 aag cac cgg tca ggg agc agc cct gaa cac gcc agg cac agt gga ggg     1296
 Lys His Arg Ser Gly Ser Ser Pro Glu His Ala Arg His Ser Gly Gly
             420                 425                 430

 agc ccg gag cat ctt cag aaa cac gct ctt ggg ggg agc cta gag cat     1344
 Ser Pro Glu His Leu Gln Lys His Ala Leu Gly Gly Ser Leu Glu His
         435                 440                 445

 ctc ccc aga gcc agg ggc acc agc ccg gag cac ctc aaa caa cat tat     1392
 Leu Pro Arg Ala Arg Gly Thr Ser Pro Glu His Leu Lys Gln His Tyr
     450                 455                 460

 gga ggg agc cct gat cac aaa cac gga gga ggc agt gga gga agt gga     1440
 Gly Gly Ser Pro Asp His Lys His Gly Gly Gly Ser Gly Gly Ser Gly
 465                 470                 475                 480

 ggc agc ggc gga ggc agc agg gag ggc acc ctc aga cgg cag gca cag     1488
 Gly Ser Gly Gly Gly Ser Arg Glu Gly Thr Leu Arg Arg Gln Ala Gln
                 485                 490                 495

 gag gac ggg tca ccc cat cac cgg aat gtc tac agt ggc atg aac gac     1536
 Glu Asp Gly Ser Pro His His Arg Asn Val Tyr Ser Gly Met Asn Asp
             500                 505                 510

 agc aaa tgc caa ttc acc cat cca ccc aaa cag aat aat aag acc ctg     1584
 Ser Lys Cys Gln Phe Thr His Pro Pro Lys Gln Asn Asn Lys Thr Leu
         515                 520                 525

 aaa ggc aag tca tta gtc ata tct gcg gat gat gga tta gat gtg att     1632
 Lys Gly Lys Ser Leu Val Ile Ser Ala Asp Asp Gly Leu Asp Val Ile
     530                 535                 540

 taa                                                                 1635
 






      <210> 245
      <211> 1596
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (874)..(1392)

      <220>
      <221> misc_feature
      <222> (1)...(1596)
      <223> n = a,t,c or g

      <400> 245
 aaagacagan aacaacccag ggaaaggaaa tggaataaaa tagcctaaat gcatgaggta     60

 ggcccctaat ctgacaacac gccggacagc tcaacttagg acttgctctc aagccaacac    120

 aactacaaaa ttgtaggcag ctacaaccgc tccttgatta aatgcgacaa actggaggga    180

 aaaagtcact tacaaatacc tacatgctgg tttttaatgc aactctcagt gtggttttcc    240

 gagggggctg caaagaggga agtagtggaa gaaacgagtt ctaaaatgag gcgctctcgt    300

 aggaggcaac aagtaagctc tgccccaaag ctccttttaa aaccaacata aatgagtaac    360

 agaagaaaag gattttgggt ccaggaagta ggctcattct ccataaccat cggaaaggaa    420

 gaggcccagg cagcgctcca catcctgacc ctagctttta acaccatcgt tttggggaga    480

 ggagaggagg aacgcaccca cagtgaggtc tccacccaac acttctccga ccccagcttc    540

 agcctggcgc accttccttc ccaaacccgc ctctcccgcc tcggagaccc cctcctcctc    600

 cctgccacca aaggccacgc agcccccatc tagccagtcc tcacggaccc tggaccaaga    660

 cgcgcctcct ggaggccgag actgcccgaa acccggcccc tgcgtccacc gggagcgcca    720

 cactctggca gctgaccggc ggctgtcgcc gggggtaagg ttaccgctcc gcttccgcgg    780

 ctggcctgcg acccggccac ctgcagggcc tggcaggcgc ccgaactcat ccttcccttg    840

 cctggtatca ttttctcagt tctcccaaaa gcc atg tcc cgg ccc ttg ctc atc     894
                                      Met Ser Arg Pro Leu Leu Ile
                                        1               5

 acc ttc acc cca gcc act gac ccc agc gac ctc tgg aag gat ggg cag      942
 Thr Phe Thr Pro Ala Thr Asp Pro Ser Asp Leu Trp Lys Asp Gly Gln
          10                  15                  20

 cag cag cca cag ccc gag aag cca gag tcc acc ctg gat ggg gct gca      990
 Gln Gln Pro Gln Pro Glu Lys Pro Glu Ser Thr Leu Asp Gly Ala Ala
      25                  30                  35

 gcc cga gct ttc tat gag gcc ctg att ggg gat gag agc agc gct cct     1038
 Ala Arg Ala Phe Tyr Glu Ala Leu Ile Gly Asp Glu Ser Ser Ala Pro
  40                  45                  50                  55

 gac tcc cag aga tct cag act gaa cct gcc aga gaa aga aag aga aag     1086
 Asp Ser Gln Arg Ser Gln Thr Glu Pro Ala Arg Glu Arg Lys Arg Lys
                  60                  65                  70

 aaa aga aga ata atg aag gca cca gca gca gaa gca gtg gca gaa gga     1134
 Lys Arg Arg Ile Met Lys Ala Pro Ala Ala Glu Ala Val Ala Glu Gly
              75                  80                  85

 gca tca gga aga cat gga caa ggg aga tcc ctt gag gct gag gat aag     1182
 Ala Ser Gly Arg His Gly Gln Gly Arg Ser Leu Glu Ala Glu Asp Lys
          90                  95                 100

 atg act cac cgg ata ctg agg gca gcc cag gag ggg gac ctg cca gaa     1230
 Met Thr His Arg Ile Leu Arg Ala Ala Gln Glu Gly Asp Leu Pro Glu
     105                 110                 115

 ctt agg aga ctg ctg gaa ccg cat gag gca gga gga gct ggg ggg aat     1278
 Leu Arg Arg Leu Leu Glu Pro His Glu Ala Gly Gly Ala Gly Gly Asn
 120                 125                 130                 135

 atc aac gcc cgg gat gcc ttc tgg tgg acc cca ctg atg tgt gct gct     1326
 Ile Asn Ala Arg Asp Ala Phe Trp Trp Thr Pro Leu Met Cys Ala Ala
                 140                 145                 150

 cga gcg ggc cag ggg gca gct gtg agc tat ctc ctg ggc gtg ggg gct     1374
 Arg Ala Gly Gln Gly Ala Ala Val Ser Tyr Leu Leu Gly Val Gly Ala
             155                 160                 165

 gct ggg tgg ggt ctg tga gttgag tggcggtgcg gtcaagtcgg ctgagaactg     1428
 Ala Gly Trp Gly Leu 
         170

 gttcctggag tacccgtgtc gggactggga gaaagggccc ggaaacggtt ctatcctcct   1488

 gtttggggaa gtggcccctt cgatttcccg gttccggtct cggcttgcgg gccccccccc   1548

 tggggccccc cggtaggggg gggggggggc cggggggccc cccaaaaa                1596




      <210> 246
      <211> 1644
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(961)

      <400> 246
 cgagtggccc cctggcagcc ctcaggccct ccggcagcct ggccgggccc gagtggcc       58                                                                 
 atg gca gca ctg gtg tgg ctg ctg gcg gga gcc agc atg tca agc ctc      106
 Met Ala Ala Leu Val Trp Leu Leu Ala Gly Ala Ser Met Ser Ser Leu
   1               5                  10                  15

 aac aag tgg atc ttc aca gtg cac ggc ttt ggg cgg ccc ctg ctg ctg      154
 Asn Lys Trp Ile Phe Thr Val His Gly Phe Gly Arg Pro Leu Leu Leu
              20                  25                  30

 tcg gcc ctg cac atg ctg gtg gca gcc ctg gca tgc cac cgg ggg gca      202
 Ser Ala Leu His Met Leu Val Ala Ala Leu Ala Cys His Arg Gly Ala
          35                  40                  45

 cgg cgc ccc atg cca ggc ggc act cgc tgc cga gtc cta ctg ctc agt      250
 Arg Arg Pro Met Pro Gly Gly Thr Arg Cys Arg Val Leu Leu Leu Ser
      50                  55                  60

 ctc acc ttt ggc acg tcc atg gcc tgc ggc aac gtg ggc cta agg gct      298
 Leu Thr Phe Gly Thr Ser Met Ala Cys Gly Asn Val Gly Leu Arg Ala
  65                  70                  75                  80

 gtg ccc ctg gac ctg gca caa ctg gtt act acc acc aca cct ctg ttc      346
 Val Pro Leu Asp Leu Ala Gln Leu Val Thr Thr Thr Thr Pro Leu Phe
                  85                  90                  95

 acc ctg gcc ctg tcg gcg ctg ctg ctg ggc cgc cgc cac cac cca ctt      394
 Thr Leu Ala Leu Ser Ala Leu Leu Leu Gly Arg Arg His His Pro Leu
             100                 105                 110

 cag ttg gcc gcc atg ggt ccg ctc tgc ctg ggg gcc gcc tgc agc ctg      442
 Gln Leu Ala Ala Met Gly Pro Leu Cys Leu Gly Ala Ala Cys Ser Leu
         115                 120                 125

 gct gga gag ttc cgg aca ccc cct acc ggc tgt ggc ttc ctg ctc gca      490
 Ala Gly Glu Phe Arg Thr Pro Pro Thr Gly Cys Gly Phe Leu Leu Ala
     130                 135                 140

 gcc acc tgc ctc cgc gga ctc aag tcg gtt cag caa agt gcc ctg ctg      538
 Ala Thr Cys Leu Arg Gly Leu Lys Ser Val Gln Gln Ser Ala Leu Leu
 145                 150                 155                 160

 cag gag gag agg ctg gac gcg gtg acc ctg ctt tac gcc acc tcg ctg      586
 Gln Glu Glu Arg Leu Asp Ala Val Thr Leu Leu Tyr Ala Thr Ser Leu
                 165                 170                 175

 ccc agc ttc tgc ctg ctg gcg ggt gca gcc ctg gtg ctg gag gct ggc      634
 Pro Ser Phe Cys Leu Leu Ala Gly Ala Ala Leu Val Leu Glu Ala Gly
             180                 185                 190

 gtt gcc cca ccg ccc act gct ggc gac tct cgc ctc tgg gcc tgc atc      682
 Val Ala Pro Pro Pro Thr Ala Gly Asp Ser Arg Leu Trp Ala Cys Ile
         195                 200                 205

 ctg ctc agc tgc ctc ctg tct gtt ctc tat aac ctg gcc agc ttc tcc      730
 Leu Leu Ser Cys Leu Leu Ser Val Leu Tyr Asn Leu Ala Ser Phe Ser
     210                 215                 220

 ctg ctg gcc ctc acc tct gcc ctc acc gtc cac gtc ctg ggc aac ctc      778
 Leu Leu Ala Leu Thr Ser Ala Leu Thr Val His Val Leu Gly Asn Leu
 225                 230                 235                 240

 acc gtg gtg ggc aac ctc atc ctg tcc cgg ctg ttg ttt ggc agc cgc      826
 Thr Val Val Gly Asn Leu Ile Leu Ser Arg Leu Leu Phe Gly Ser Arg
                 245                 250                 255

 ctc agt gcc ctc agc tac gtg ggc atc gca ctc act ctt tca gga atg      874
 Leu Ser Ala Leu Ser Tyr Val Gly Ile Ala Leu Thr Leu Ser Gly Met
             260                 265                 270

 ttc ctt tac cac aac tgc gag ttc gtg gcc tcc tgg gct gcc cgt cgg      922
 Phe Leu Tyr His Asn Cys Glu Phe Val Ala Ser Trp Ala Ala Arg Arg
         275                 280                 285

 ggg ctg tgg cgg agg gac cag ccc agc aag ggt ctt tga gacctggggg       971
 Gly Leu Trp Arg Arg Asp Gln Pro Ser Lys Gly Leu 
     290                 295                 300

 atctcaggag ccacctggga tggccctggc ctgaatccag cctccgctgt ggccatagaa   1031

 ggaatggaga acagggctgg gcatggtggc tcacgcctat aatcccagca cttccagagt   1091

 ccgaggtggg tggatcacct gaggccagga gttcgagacc agcctggcta acatggcaaa   1151

 acctcatctc tactaaaaat agaaaaatta gctgggcatg gtggcgcgtg cctatagtcc   1211

 cagctacatg ggaggctaag gtgggaggat cacttgagcc ctggagatcg aggctgcagt   1271

 aagccaagat cgcatgctac tgcactccag cctgggagac agagcgagac gctgtctcaa   1331

 ttaaaaaaaa aaaaaagtgg agaactggca gtgacctcta ctgggggcca tggcagggag   1391

 gggagccttc tggaagggct gccttggaga ttggaatggg gactcccagg gagacctgcg   1451

 ttccatccct gcctgcctca cccctgccac agactctgca caccactgga gtggtgggtc   1511

 caagcctggc acagtccctg tgcttgtcag agtcattatt atgattaata tcaattacga   1571

 tgccaaaaat tgctgggcaa actttgaaga cctcaacttg ttacaatgac gatgatgatg   1631

 attcttggcg gtg                                                      1644




      <210> 247
      <211> 2153
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (198)..(1166)

      <400> 247
 ctctctcctg cttcctccct tagggctgac tgtgctcagc ctgccagctc tgacatgtgc     60

 tgtctcccac cctctgactc ccctcaagct gcagtgggac tggaagactg gcaggaagct    120

 agggtacaac tggaacacag gcaggtcgac ctgcagtccc taggcctggc cccgtccctc    180

 catgtacaca catatac   atg ttg gca cac aca cag tgg cac aca tgc caa     230
                      Met Leu Ala His Thr Gln Trp His Thr Cys Gln
                        1               5                  10

 aga ctc tct cag ctg aca cac aga tcc att ctc aag tat cta ctg ata      278
 Arg Leu Ser Gln Leu Thr His Arg Ser Ile Leu Lys Tyr Leu Leu Ile
              15                  20                  25

 gac act cat gcg tgc caa gtc ctc atc ctc aaa cat aca cat gcc tct      326
 Asp Thr His Ala Cys Gln Val Leu Ile Leu Lys His Thr His Ala Ser
          30                  35                  40

 ctt tct ctc ccg tct tgc cag gag tgt ttc ccc tcc tcc atc ccc tct      374
 Leu Ser Leu Pro Ser Cys Gln Glu Cys Phe Pro Ser Ser Ile Pro Ser
      45                  50                  55

 gcc tcc cat ctg gtg tcc cac cct cac ccc cca ccc agc cca agg tgg      422
 Ala Ser His Leu Val Ser His Pro His Pro Pro Pro Ser Pro Arg Trp
  60                  65                  70                  75

 gga cag aca cct gag ggg ctg cca gct gct tcc ccg tgt ggg ccc ggg      470
 Gly Gln Thr Pro Glu Gly Leu Pro Ala Ala Ser Pro Cys Gly Pro Gly
                  80                  85                  90

 ccg cgc tca tgc ttc tcg tcc atc ctg ccc aca ggg gac tcg tgg ggg      518
 Pro Arg Ser Cys Phe Ser Ser Ile Leu Pro Thr Gly Asp Ser Trp Gly
              95                 100                 105

 atg tta gcg tgc ctg tgc acg gtg ctc tgg cac ctc cct gca gtg cca      566
 Met Leu Ala Cys Leu Cys Thr Val Leu Trp His Leu Pro Ala Val Pro
         110                 115                 120

 gct ctc aat cgc aca ggg gac cca ggg cct ggc ccc tcc atc cag aaa      614
 Ala Leu Asn Arg Thr Gly Asp Pro Gly Pro Gly Pro Ser Ile Gln Lys
     125                 130                 135

 acc tat gac ctc acc cgc tac ctg gag cac caa ctc cgc agc ttg gct      662
 Thr Tyr Asp Leu Thr Arg Tyr Leu Glu His Gln Leu Arg Ser Leu Ala
 140                 145                 150                 155

 ggg acc tat ctg aac tac ctg ggc ccc cct ttc aac gag cca gac ttc      710
 Gly Thr Tyr Leu Asn Tyr Leu Gly Pro Pro Phe Asn Glu Pro Asp Phe
                 160                 165                 170

 aac cct ccc cgc ctg ggg gca gag act ctg ccc agg gcc act gtt gac      758
 Asn Pro Pro Arg Leu Gly Ala Glu Thr Leu Pro Arg Ala Thr Val Asp
             175                 180                 185

 ttg gag gtg tgg cga agc ctc aat gac aaa ctg cgg ctg acc cag aac      806
 Leu Glu Val Trp Arg Ser Leu Asn Asp Lys Leu Arg Leu Thr Gln Asn
         190                 195                 200

 tac gag gcc tac agc cac ctt ctg tgt tac ttg cgt ggc ctc aac cgt      854
 Tyr Glu Ala Tyr Ser His Leu Leu Cys Tyr Leu Arg Gly Leu Asn Arg
     205                 210                 215

 cag gct gcc act gct gag ctg cgc cgc agc ctg gcc cac ttc tgc acc      902
 Gln Ala Ala Thr Ala Glu Leu Arg Arg Ser Leu Ala His Phe Cys Thr
 220                 225                 230                 235

 agc ctc cag ggc ctg ctg ggc agc att gcg ggc gtc atg gca gct ctg      950
 Ser Leu Gln Gly Leu Leu Gly Ser Ile Ala Gly Val Met Ala Ala Leu
                 240                 245                 250

 ggc tac cca ctg ccc cag ccg ctg cct ggg act gaa ccc act tgg act      998
 Gly Tyr Pro Leu Pro Gln Pro Leu Pro Gly Thr Glu Pro Thr Trp Thr
             255                 260                 265

 cct ggc cct gcc cac agt gac ttc ctc cag aag atg gac gac ttc tgg     1046
 Pro Gly Pro Ala His Ser Asp Phe Leu Gln Lys Met Asp Asp Phe Trp
         270                 275                 280

 ctg ctg aag gag ctg cag acc tgg ctg tgg cgc tcg gcc aag gac ttc     1094
 Leu Leu Lys Glu Leu Gln Thr Trp Leu Trp Arg Ser Ala Lys Asp Phe
     285                 290                 295

 aac cgg ctc aag aag aag atg cag cct cca gca gct gca gtc acc ctg     1142
 Asn Arg Leu Lys Lys Lys Met Gln Pro Pro Ala Ala Ala Val Thr Leu
 300                 305                 310                 315

 cac ctg ggg gct cat ggc ttc tga cttctgacct tctcctcttc gctccccctt    1196
 His Leu Gly Ala His Gly Phe 
                 320

 caaaccctgc tcccactttg tgagagccag ccctgtatgc caacacctgt tgagccagga   1256

 gacagaagct gtgagcctct ggccctttcc tggaccggct gggcgtgtga tgcgatcagc   1316

 cctgtctcct ccccacctcc caaaggtcta ccgagctggg gaggaggtac agtaggccct   1376

 gtcctgtcct gtttctacag gaagtcatgc tcgagggagt gtgaagtggt tcaggttggt   1436

 gcagaggcgc tcatggcctc ctggcttctt gcctaccact tggccagtgc ccacccagcc   1496

 cctcaggtgg cacatctgga gggcaggggt tgaggggcca ccaccacaca tgcctttctg   1556

 gggtgaagcc ctttggctgc cccactctcc ttggatgggt gttgctccct tatccccaaa   1616

 tcactctata catccaattc aggaaacaaa catggtggca attctacaca aaaagagatg   1676

 agattaacag tgcagggttg gggtctgcat tggaggtgcc ctataaacca gaagagaaaa   1736

 tactgaaagc acaggggcag ggacagacca gaccagaccc aggagtctcc aaagcacaga   1796

 gtggcaaaca aaacccgagc tgagcatcag gaccttgcct cgaattgtct tccagtatta   1856

 cggtgcctct tctctgcccc ctttcccagg gtatctgtgg gttgccaggc tggggagggc   1916

 aaccatagcc acaccacagg atttcctgaa agtttacaat gcagtagcat tttggggtgt   1976

 agggtggcag ctccccaagg ccctgccccc cagccccacc cactcatgac tctaagtgtg   2036

 ttgtattaat atttatttat ttggagatgt tatttattag atgatattta ttgcagaatt   2096

 tctattcttg tattaacaaa taaaatgctt gccccagaaa aaaaaaaaaa aaaaaaa      2153




      <210> 248
      <211> 558
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(558)

      <400> 248
 ttttttataa tgccaacttt gtacaaaaaa gcaggctccg cggccgcccc cttcacc        57                                                                 
 atg tcc ttc act gta tcc atg gca atc ggg ctg gta ctt gga gga ttt      105
 Met Ser Phe Thr Val Ser Met Ala Ile Gly Leu Val Leu Gly Gly Phe
   1               5                  10                  15

 att tgg gct gtg ttc att tgt ctg tct cga aga aga aga gcc agt gct      153
 Ile Trp Ala Val Phe Ile Cys Leu Ser Arg Arg Arg Arg Ala Ser Ala
              20                  25                  30

 ccc atc tca cag tgg agt tca agc agg aga tct agg tct tct tac acc      201
 Pro Ile Ser Gln Trp Ser Ser Ser Arg Arg Ser Arg Ser Ser Tyr Thr
          35                  40                  45

 cac ggc ctc aac aga act gga ttt tac cgc cac agt ggc tgt gaa cgt      249
 His Gly Leu Asn Arg Thr Gly Phe Tyr Arg His Ser Gly Cys Glu Arg
      50                  55                  60

 cga agc aac ctc agc ctg gcc agt ctc acc ttc cag cga caa gct tcc      297
 Arg Ser Asn Leu Ser Leu Ala Ser Leu Thr Phe Gln Arg Gln Ala Ser
  65                  70                  75                  80

 ctg gaa caa gca aat tcc ttt cca aga aaa tca agt ttc aga gct tct      345
 Leu Glu Gln Ala Asn Ser Phe Pro Arg Lys Ser Ser Phe Arg Ala Ser
                  85                  90                  95

 act ttc cat ccc ttt ctg caa tgt cca cca ctt cct gtg gaa att gag      393
 Thr Phe His Pro Phe Leu Gln Cys Pro Pro Leu Pro Val Glu Ile Glu
             100                 105                 110

 agt cag ctg gtg act ctc cct tct tcc aat atc tct ccc acc atc agc      441
 Ser Gln Leu Val Thr Leu Pro Ser Ser Asn Ile Ser Pro Thr Ile Ser
         115                 120                 125

 act tcc cac agt ctg agc cgt cct gac tac tgg tcc agt aac agt ctt      489
 Thr Ser His Ser Leu Ser Arg Pro Asp Tyr Trp Ser Ser Asn Ser Leu
     130                 135                 140

 cga gtg ggc ctt tca aca ccg ccc cca cct gcc tat gag tcc atc atc      537
 Arg Val Gly Leu Ser Thr Pro Pro Pro Pro Ala Tyr Glu Ser Ile Ile
 145                 150                 155                 160

 aag gca ttc cca gat tcc tga                                          558
 Lys Ala Phe Pro Asp Ser 
                 165





      <210> 249
      <211> 3064
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(1031)

      <400> 249
 aattcggcac gagccgacgc cac    atg gcg gcg ccc agt ggc gtc cac ctg      50
                              Met Ala Ala Pro Ser Gly Val His Leu
                                1               5

 ctc gtc cgc aga ggt tct cat aga att ttc tct tca cca ctc aat cat       98
 Leu Val Arg Arg Gly Ser His Arg Ile Phe Ser Ser Pro Leu Asn His
  10                  15                  20                  25

 atc tac tta cac aag cag tca agc agt caa caa aga aga aat ttc ttt      146
 Ile Tyr Leu His Lys Gln Ser Ser Ser Gln Gln Arg Arg Asn Phe Phe
                  30                  35                  40

 ttt cgg aga caa aga gat att tca cac agt ata gtt ttg ccg gct gca      194
 Phe Arg Arg Gln Arg Asp Ile Ser His Ser Ile Val Leu Pro Ala Ala
              45                  50                  55

 gtt tct tca gct cat ccg gtt cct aag cac ata aag aag cca gac tat      242
 Val Ser Ser Ala His Pro Val Pro Lys His Ile Lys Lys Pro Asp Tyr
          60                  65                  70

 gtg acg aca ggc att gta cca gac tgg gga gac agc ata gaa gtt aag      290
 Val Thr Thr Gly Ile Val Pro Asp Trp Gly Asp Ser Ile Glu Val Lys
      75                  80                  85

 aat gaa gat cag att caa ggg ctt cat cag gct tgt cag ctg gcc cgc      338
 Asn Glu Asp Gln Ile Gln Gly Leu His Gln Ala Cys Gln Leu Ala Arg
  90                  95                 100                 105

 cac gtc ctc ctc ttg gct ggg aag agt tta aag gtt gac atg aca act      386
 His Val Leu Leu Leu Ala Gly Lys Ser Leu Lys Val Asp Met Thr Thr
                 110                 115                 120

 gaa gag ata gat gct ctt gtt cat cgg gaa atc atc agt cat aat gcc      434
 Glu Glu Ile Asp Ala Leu Val His Arg Glu Ile Ile Ser His Asn Ala
             125                 130                 135

 tat ccc tca cct cta ggc tat gga ggt ttt cca aaa tct gtt tgt acc      482
 Tyr Pro Ser Pro Leu Gly Tyr Gly Gly Phe Pro Lys Ser Val Cys Thr
         140                 145                 150

 tct gta aac aac gtg ctc tgt cat ggt att cct gac agt cga cct ctt      530
 Ser Val Asn Asn Val Leu Cys His Gly Ile Pro Asp Ser Arg Pro Leu
     155                 160                 165

 cag gat gga gat att atc aac att gat gtc aca gtc tat tac aat ggc      578
 Gln Asp Gly Asp Ile Ile Asn Ile Asp Val Thr Val Tyr Tyr Asn Gly
 170                 175                 180                 185

 tac cat gga gac acc tct gaa aca ttt ttg gtg ggc aat gtg gac gaa      626
 Tyr His Gly Asp Thr Ser Glu Thr Phe Leu Val Gly Asn Val Asp Glu
                 190                 195                 200

 tgt ggt aaa aag tta gtg gag gtt gcc agg agg tgt aga gat gaa gca      674
 Cys Gly Lys Lys Leu Val Glu Val Ala Arg Arg Cys Arg Asp Glu Ala
             205                 210                 215

 att gca gct tgc aga gca ggg gct ccc ttc tct gta att gga aac aca      722
 Ile Ala Ala Cys Arg Ala Gly Ala Pro Phe Ser Val Ile Gly Asn Thr
         220                 225                 230

 atc agc cac ata act cat cag aat ggt ttt caa gtc tgt cca cat ttt      770
 Ile Ser His Ile Thr His Gln Asn Gly Phe Gln Val Cys Pro His Phe
     235                 240                 245

 gtg gga cat gga ata gga tct tac ttt cat gga cat cca gaa att tgg      818
 Val Gly His Gly Ile Gly Ser Tyr Phe His Gly His Pro Glu Ile Trp
 250                 255                 260                 265

 cat cat gca aac gac agt gat cta ccc atg gag gag ggc atg gca ttc      866
 His His Ala Asn Asp Ser Asp Leu Pro Met Glu Glu Gly Met Ala Phe
                 270                 275                 280

 act ata gag cca atc atc acg gag gga tcc cct gaa ttt aaa gtc ctg      914
 Thr Ile Glu Pro Ile Ile Thr Glu Gly Ser Pro Glu Phe Lys Val Leu
             285                 290                 295

 gag gat gca tgg act gtg gtc tcc cta gac aat caa agg tcg gcg cag      962
 Glu Asp Ala Trp Thr Val Val Ser Leu Asp Asn Gln Arg Ser Ala Gln
         300                 305                 310

 ttc gag cac acg gtt ctg atc acg tcg agg ggc gcg cag atc ctg acc     1010
 Phe Glu His Thr Val Leu Ile Thr Ser Arg Gly Ala Gln Ile Leu Thr
     315                 320                 325

 aaa cta ccc cat gag gcc tga gg agccgcccga aggtcgcggt gacctggtgc     1063
 Lys Leu Pro His Glu Ala 
 330                 335

 ctttttaaat aaattgctga aatttggctg gagaactttt agaagaaaca gggaaatgac   1123

 cggtggtgcg gtaacctgcg tggctcctga tagcgtttgg aagaacgcgg gggagactga   1183

 agagcaactg ggaactcgga tctgaagccc tgctggggtc gcgcggcttt ggaaaaacaa   1243

 atcctggccc tggactcggt ttcccagcgc ggtcaacgca tctggagggg actggaggaa   1303

 acccccttgt tggaagagat tccaagagaa gcacggtttt ctctttccct tgccctgact   1363

 gttggagtaa aaaacctctt aaatccattg tatcagaggt ccttacctct ctgacagtta   1423

 caatgatctt tgtatctgaa ctttgcacgt ctgccgaaaa atccgaacct gttgactggg   1483

 atttttaaga atccgtttct cccttttgtg tattccatat tggccggccc caaggatgct   1543

 cgcagaagcc agcccccaac cccagccctt ccgtatcttt cccctccatc gcggctttgc   1603

 gatgaaagat tagcccgcga acagaggcat tgattacaaa catgtccttg gcagtggact   1663

 ctgggcctgg cattcttcag gtttctgtca atccagaaac gcgactttcc tggacccctg   1723

 cggctcttcc tcccccgccc acatccagcc ctccaaggcc agtccagagg tgaagtttga   1783

 ggccctcccc ccacccaccc cacacgcacg cacgcacgct agaccgtttg ctgcactagg   1843

 aattcgagct tgggccccac tcgcccaggt gtgaacagtg gctgattagt gggcggtcta   1903

 gtctctaaaa tgacccctcc ccagactggc ccttctcgca tcgggacccg cgcttgcacg   1963

 ctgcaggagc cgcaaacgtc agctgttctg gaaaccgaga gggtcccaga gagaggagat   2023

 acgggcgcat ttgagagcaa gggcctactt ggccgggact gaagcttgcg agttgagctc   2083

 cagttcggcc ggcagttcca tcccgcttca ggaacaggaa tccaagggcc cacgctctgt   2143

 ctgccaaggg ccattcctgc ccggagcacc ctcctttccc ttgcgcttgc tctccggtac   2203

 ctgttcctca cctgagctca agggcaggga gaggccgggc ctctggcagt ccacgaagga   2263

 agccgtctgc cttcggttat gattttagga acaagtccaa cgagggtgtt caagcagtta   2323

 atggttgtgc taactcttgt ttctactgaa gcgggttttg caaagctgac atcccttaaa   2383

 gataacttgg gctttcggaa gcggcaagga aatggcacct gtagttgcca ggacaggtgg   2443

 tgtcctcggc caggactaag agccagctca tctttgtaac attcataata cgggaaactg   2503

 aggaccaggt ggctcggaaa agagatgagt tccagctttt acctaacaca gggttctctc   2563

 gtcgtccccc aacccctcca gctcggcttc tttgtgtcca gggttgtaga tttttggata   2623

 gaggtgtttc tgattctagt gagtctgaga actggaaaag accaaggagg ggttgatgat   2683

 ttacaaggtc catagaaaaa ctttttgtgt ggtcggaagt tggccaagca gaggcccaca   2743

 gcctgatgct actgcccccc acccccccaa agatctgaat tccctaaaga tcaagagggt   2803

 tcagctggcc ttgggagatg tttgctggag aatgacttca gttttctcct aaggcaatca   2863

 gattgcaacc attagcattg tatcttatct gcaaatcagt ttactccgag gttccccaag   2923

 gatagtttta ttaggaccac aggactttac taaccactga ggtaacacgc tgcttgtgca   2983

 gcaattattt tgaggtggag gtatttatgg gacaagttta taattccatt tattaaaggg   3043

 actaacctaa aaaaaaaaaa a                                             3064




      <210> 250
      <211> 1788
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (149)..(1075)

      <400> 250
 gcgcccagtc cgcgggccgc gccgccgctc ccgccgctcc cgccgctccc gcagccgccc     60

 cgccgcccgc ccggagcccc gcgtccctag gcctggctcc cgcctgcccg agacccgccc    120

 agcctgcccc gctcagccgc cagagaag   atg cgg ctg ctc ccg gaa tgg ttc     172
                                  Met Arg Leu Leu Pro Glu Trp Phe
                                    1               5

 ctc ttg ctc ttt ggc ccg tgg ctc ctt agg aag gcc gtc agt gcc cag      220
 Leu Leu Leu Phe Gly Pro Trp Leu Leu Arg Lys Ala Val Ser Ala Gln
      10                  15                  20

 ata cca gag tcc gga agg ccg cag tac ctg ggg ctg cgc ccc gcc gcg      268
 Ile Pro Glu Ser Gly Arg Pro Gln Tyr Leu Gly Leu Arg Pro Ala Ala
  25                  30                  35                  40

 gcc gga gcg ggt gcc ccc ggc cag cag ctc cca gag cca agg tct tcg      316
 Ala Gly Ala Gly Ala Pro Gly Gln Gln Leu Pro Glu Pro Arg Ser Ser
                  45                  50                  55

 gac ggc cta ggc gtg ggc cgc gcc tgg agc tgg gcc tgg ccg acc aac      364
 Asp Gly Leu Gly Val Gly Arg Ala Trp Ser Trp Ala Trp Pro Thr Asn
              60                  65                  70

 cac acg ggg gcg ctg gcc cgg gca ggg gca gcc ggg gcg ttg ccc gcg      412
 His Thr Gly Ala Leu Ala Arg Ala Gly Ala Ala Gly Ala Leu Pro Ala
          75                  80                  85

 cag cgc acc aag agg aag ccg tcc atc aag gcg gcg cgc gcc aaa aag      460
 Gln Arg Thr Lys Arg Lys Pro Ser Ile Lys Ala Ala Arg Ala Lys Lys
      90                  95                 100

 atc ttc ggc tgg ggg gac ttc tac ttt cgg gtg cat acc ctc aag ttt      508
 Ile Phe Gly Trp Gly Asp Phe Tyr Phe Arg Val His Thr Leu Lys Phe
 105                 110                 115                 120

 tcg ctg ctg gtg acc ggc aag atc gtg gac cat gtg aac ggt acc ttc      556
 Ser Leu Leu Val Thr Gly Lys Ile Val Asp His Val Asn Gly Thr Phe
                 125                 130                 135

 agt gtg tat ttc cgc cac aac tcg tcc agc ctg ggc aac ctc agt gtc      604
 Ser Val Tyr Phe Arg His Asn Ser Ser Ser Leu Gly Asn Leu Ser Val
             140                 145                 150

 agc atc gtg ccg ccc tcc aag cgt gtc gag ttc gga gga gtc tgg ctg      652
 Ser Ile Val Pro Pro Ser Lys Arg Val Glu Phe Gly Gly Val Trp Leu
         155                 160                 165

 ccc ggg cct gtc ccc cac cct ctg cag tct acg ctc gcc ctg gag ggg      700
 Pro Gly Pro Val Pro His Pro Leu Gln Ser Thr Leu Ala Leu Glu Gly
     170                 175                 180

 gtg ctt cct ggg ctg ggg ccc ccg ctg ggg atg gca gca gca gcg gcg      748
 Val Leu Pro Gly Leu Gly Pro Pro Leu Gly Met Ala Ala Ala Ala Ala
 185                 190                 195                 200

 ggg ccg ggg ctt ggg ggc tcc ctc ggg ggc gca ctg gcg ggg ccg ctt      796
 Gly Pro Gly Leu Gly Gly Ser Leu Gly Gly Ala Leu Ala Gly Pro Leu
                 205                 210                 215

 ggg ggc gcg ttg gga gtg cct ggg gcc aaa gag tca cgc gct ttc aat      844
 Gly Gly Ala Leu Gly Val Pro Gly Ala Lys Glu Ser Arg Ala Phe Asn
             220                 225                 230

 tgc cac gtg gag tat gag aag aca aac cgc gcg cgc aag cac cga ccg      892
 Cys His Val Glu Tyr Glu Lys Thr Asn Arg Ala Arg Lys His Arg Pro
         235                 240                 245

 tgc ctg tac gac ccg tcg cag gtg tgc ttc acc gag cac acg cag agc      940
 Cys Leu Tyr Asp Pro Ser Gln Val Cys Phe Thr Glu His Thr Gln Ser
     250                 255                 260

 cag gcc gcc tgg ctc tgt gcc aag ccc ttc aaa gtc atc tgt atc ttc      988
 Gln Ala Ala Trp Leu Cys Ala Lys Pro Phe Lys Val Ile Cys Ile Phe
 265                 270                 275                 280

 gtc tct ttc ctc agc ttt gac tac aaa ctg gtg cag aag gtg tgc cca     1036
 Val Ser Phe Leu Ser Phe Asp Tyr Lys Leu Val Gln Lys Val Cys Pro
                 285                 290                 295

 gac tat aac ttc cag agt gag cac ccc tac ttc gga tag cgcccctccc      1085
 Asp Tyr Asn Phe Gln Ser Glu His Pro Tyr Phe Gly 
             300                 305

 cagccagtcc tgagcctccc gccaaatccc agcctcacta ggtgggaccc ccttcccagt   1145

 gttctgccgc tcctgtggcc atgtcgccca ctccttccac tctgggggcg gaggggaatg   1205

 gcttctcggg accctcagct agcgtgggtg cccttttcct tatgcggagt gcccgcaagg   1265

 ctggggtagc cccctccagt acaccccaaa gtgaaaggga taagagtgca gccccagaat   1325

 aggcggggct tggaggcggt cccaatgtcc cctgggtcca cagtgggtcc ccttttcacc   1385

 cttggcgcta ggctgcgcac tccctttccc cgcagcttta ataactcctg gcctggcacc   1445

 ctcaccccac cctgactttc ccatccccca gcgcttgtcc tgcttcaccc taccccgcct   1505

 aagactgtaa aggcctaaaa acctcggcct gtcctcccac cattctgcct gccatatgcc   1565

 tgtccccttt tcctccaaac cctattaggg taccggaagc agaacccctg ggctgaggcc   1625

 ctggccctgc ccccggcccc tgcccctgcc cgcccccctc cagtccaggc agtcgagctc   1685

 cacctgccct ctcctgctgc ttcctctcgg tgatattttt tctacgccaa aacagacggg   1745

 aaagggaaca aaataaagtg aaatccaata caaaaaaaaa aaa                     1788




      <210> 251
      <211> 755
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (221)..(406)

      <400> 251
 gcacattaac aatgtcgtta ggtaacaggg aatttttcag ctccattata atcctatggg     60

 accaccatca tatgatacag tccatcattg accgagatgt cattaagagg tacatcaaca    120

 gaaataatgt atattatgta caaaaataaa tgaattaaaa ttaaatgaat acttgataaa    180

 tgacaagtta taaaagtcaa tttctgattc taaaaaatac  atg tta ata ttt ttt     235
                                              Met Leu Ile Phe Phe
                                                1               5

 cta cag agc atg gaa aat aca tta gat gtt ata gaa cat ttg gca aat      283
 Leu Gln Ser Met Glu Asn Thr Leu Asp Val Ile Glu His Leu Ala Asn
                  10                  15                  20

 aat gtt aaa gaa aag tta tca gag aag cag gct tat tca ttt caa cta      331
 Asn Val Lys Glu Lys Leu Ser Glu Lys Gln Ala Tyr Ser Phe Gln Leu
              25                  30                  35

 agt aaa gaa acg gag gag cag aag cca aaa tta gaa aga gtg acc aaa      379
 Ser Lys Glu Thr Glu Glu Gln Lys Pro Lys Leu Glu Arg Val Thr Lys
          40                  45                  50

 cag gta tcg ata tct ttt aaa aac tga ccttt catatttaca tttttgaagt      431
 Gln Val Ser Ile Ser Phe Lys Asn 
      55                  60

 cccaaatcct ccttcatcta ttaaaaatat taaattctgg taaacacgtt tatagaataa    491

 ttgactatta tttaccaaca gtgtgcaaaa ctcacaaagg aaatccgtct tttgaaagac    551

 acaaaagatg aaacaatgga agaacaagac atcaaacttc gtgaaatgaa acagtttcac    611

 aaagttattg atgaaatgtt agttgatatc atagaagaaa atactgagat ccgtattatc    671

 cttcaaacat actttcaaca ggtaatacag caccttctat taaatatttc ttaaaaactt    731

 catgaaaata aaaactttca tgac                                           755




      <210> 252
      <211> 2983
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2405)..(2827)

      <400> 252
 agtctggccg ccatgttgga gctttcgctg ttcggggccc ggcctgctcc gggccctccc     60

 agcgtcgccg ctagctgact tagggctccc gcccacactg cgcacggcct tgctgagggc    120

 cggctcgtag tgggaggctt cgcgttcacc tgaacatttc cgcctcctct ggatggggga    180

 tgagaggcgg ggctgatgca tcgcagcagt cctggaccct gacttcggac ttggagaaga    240

 aacgccgagg aggaacggga gttagggggt tagcagcttg gcgcgctggg agccggccac    300

 ccctggtctc cggacttcac ttcccaggag gcctcgcgcg cgactggaag tgctgcgagc    360

 ctataagaag gcgaggcggc acccgccgct ctgctctggg gcggcattgc cagccggctg    420

 taggcattca gggcagtgtc ttctgcatct cctaggaacc tcgggagcgg cagctccggc    480

 gcctggtagc gagaggcggg ttccggagat cccggcctca cttcgtccca ctgtggttag    540

 gggtgagtcc tgcaaatgtt aagtgatttg ctcaaggtgc ccatttcgca ggaattggag    600

 cccaggccag ttctctgagc ctatcattag ggctaaagga gtgcgtgatc agaatggtgt    660

 ctggacggtt ctacttgtcc tgcctgctgc tggggtccct gggctctatg tgcatcctct    720

 tcactatcta ctggatgcag tactggcgtg gtggctttgc ctggaatggc agcatctaca    780

 tgttcaactg gcacccagtg cttatggttg ctggcatggt ggtattctat ggaggtgcgt    840

 cactggtgta ccgcctgccc cagtcgtggg tggggcccaa actgccctgg aaactcctcc    900

 atgcagcgct gcacctgatg gccttcgtcc tcactgttgt ggggctggtt gctgtcttta    960

 cgtttcacaa ccatggaagg actgccaacc tctactccct tcacagctgg ctgggcatca   1020

 ccactgtctt cctcttcgcc tgccagtggt tcctgggctt tgctgtcttc ctcctgccct   1080

 gggcgtccat gtggctgcgc agcctcctaa aacctatcca cgtctttttt ggagccgcca   1140

 tcctctctct gtccatcgca tccgtcattt cgggcattaa tgagaagctt ttcttcagtt   1200

 tgaaaaacac caccaggcca taccacagcc tgcccagtga ggcggtcttt gccaacagca   1260

 ccgggatgct ggtggtggcc tttgggctgc tggtgctcta catccttctg gcttcatctt   1320

 ggaagcgccc agagccgggg atcctgaccg acagacagcc cctgctgcat gatggggagt   1380

 gaagcagcag gaaggggctc ccaagagctc ctggtggtgc agcctgtgct cccctcagaa   1440

 gctctgctct tcccagggct cccggctggt ttcagcaggc gactttcttc caatgctggg   1500

 cccagacttc ttgcctgggt gctggcctgc cctctccggc cgcttgctgc ctgtctgctt   1560

 tccttggtgg ctttgcctgg gtgctgggcc tgccctctcc ggccgcttgc tgcctgtctg   1620

 ctttccttgg tggctttgcc tgggtgctgg gcctgccttc tctggctgct tgctgcctgt   1680

 ctgctttcct tggtggcttt ggcttctgca ctccttggcg tcagcctctc aggtcctcca   1740

 ttcacacgag gtcctcctcg ctctggccgc tcttgctgct cctgtctgaa gaaatcagac   1800

 tgatttcctc ttaagactcc tagggatgtg gtgaagagct gggactcaag tgcagtccac   1860

 ggtgtgaaac atgagggagg tgaggtgtcc gtccacttcc cccataaagg tgtgcatttc   1920

 agttaggctg ccccgccaca gagcaggctt catctgctct gccatccagc cccatctgga   1980

 tgtgaggtgg ggtggagaca tcatggggtg attgcagaaa gggggagtgg cggcccacgc   2040

 agcttctgct gaggagctga ccgctctgag ctgttctgtt tcgtattgct gctctgtgtc   2100

 tgcatgtatt gtgaccgtgc ggctccacct cttccagctg ctgctacagc tgaggcctgg   2160

 atcccggcct ttccctgtga cttacgtgtc tgtcaccggc aggcagccct acaaatcctg   2220

 gtgacctgct ctcccaagaa cagagcctgt ccccagatgt cccagtagcg atgagtaaca   2280

 gaggtggctg tggacttcct ctacttctcc ttgctggatc agggccttcc tgcctcccgc   2340

 tgggcaggtc tggccttgct ctcttggcag ggccccagcc cctctgacca ctctgcagct   2400

 cacc atg cag ctg atg cca aag ttg tgg tgt cca gtg tgc agc agc cct    2449
      Met Gln Leu Met Pro Lys Leu Trp Cys Pro Val Cys Ser Ser Pro
        1               5                  10                  15

 ggg agc cac tgc cac ctt cag agg ggt tcc ttg ctg aga ccc aca ttg     2497
 Gly Ser His Cys His Leu Gln Arg Gly Ser Leu Leu Arg Pro Thr Leu
                  20                  25                  30

 ctt cac ctg gcc cca cca tgg ctg ctt gcc tgg ccc aac cta gcg ttc     2545
 Leu His Leu Ala Pro Pro Trp Leu Leu Ala Trp Pro Asn Leu Ala Phe
              35                  40                  45

 tgt gcc atg cta gag ctt gag ctg ttg ctc ttc ttc agg gga gga aat     2593
 Cys Ala Met Leu Glu Leu Glu Leu Leu Leu Phe Phe Arg Gly Gly Asn
          50                  55                  60

 agg gtg gag agc ggg aag ggt ctt gct cct aag tgt tgc tgc tgt ggc     2641
 Arg Val Glu Ser Gly Lys Gly Leu Ala Pro Lys Cys Cys Cys Cys Gly
      65                  70                  75

 ttt ttt gcc ttc tcc aaa gac gca ctg cca ggt ccc aag ctt cag act     2689
 Phe Phe Ala Phe Ser Lys Asp Ala Leu Pro Gly Pro Lys Leu Gln Thr
  80                  85                  90                  95

 gct gtg ctt agt aag caa gtg aga agc ctg ggg ttt gga gcc cac cta     2737
 Ala Val Leu Ser Lys Gln Val Arg Ser Leu Gly Phe Gly Ala His Leu
                 100                 105                 110

 ctc tct ggc agc atc agc atc cta ctc ctg gca aca tca ggc caa cgt     2785
 Leu Ser Gly Ser Ile Ser Ile Leu Leu Leu Ala Thr Ser Gly Gln Arg
             115                 120                 125

 cca ccc cag cct cac att gcc aga tgt tgg cag aag ggc taa tattgac     2834
 Pro Pro Gln Pro His Ile Ala Arg Cys Trp Gln Lys Gly 
         130                 135                 140

 cgtcttgact ggctggagcc ttcaaagcca ctgggatgtc ctccaggcac ctgggtccca   2894

 tgaccagctc cccgtctcca taggggtagg catttcactg gtttatgaag ctcgagtttc   2954

 attaaatatg ttaagaatca aaaaaaaaa                                     2983




      <210> 253
      <211> 811
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (258)..(770)

      <400> 253
 ggggggcggg ggggtgtttt caaggggaat ggctggaggg tctcaggaga ggaaggtggg     60

 tggagtagtg gtggggctca gcaaggaggt gaggaggagg ggcagctctg agaccccagg    120

 actacagata gacaggagtc ctttccggca ggcactgtga ggagcagggt gggcttcacc    180

 ttcctctctc tcccagcagt tctcaaggca ccacaaaaca actgccagcc tcccttcttc    240

 atccactctt tcaggca   atg act gac cca ctg tgc cat ctg agc agc ctc     290
                      Met Thr Asp Pro Leu Cys His Leu Ser Ser Leu
                        1               5                  10

 acg ctg tcc cac tgc aaa ctc cct gac gcg gtc tgc cga gac ctt tct      338
 Thr Leu Ser His Cys Lys Leu Pro Asp Ala Val Cys Arg Asp Leu Ser
              15                  20                  25

 gag gcc ctg agg gca gcc ccc gca ctg acg gag ctg ggc ctc ctc cac      386
 Glu Ala Leu Arg Ala Ala Pro Ala Leu Thr Glu Leu Gly Leu Leu His
          30                  35                  40

 aac agg ctc agt gag gca gga ctg cgt atg ctg agt gag ggc cta gcc      434
 Asn Arg Leu Ser Glu Ala Gly Leu Arg Met Leu Ser Glu Gly Leu Ala
      45                  50                  55

 tgg ccg cag tgc agg gtg cag acg gtc agg gta cag ctg cct gac ccc      482
 Trp Pro Gln Cys Arg Val Gln Thr Val Arg Val Gln Leu Pro Asp Pro
  60                  65                  70                  75

 cag cga ggg ctc cag tac ctg gtg ggt atg ctt cgg cag agc ccc gcc      530
 Gln Arg Gly Leu Gln Tyr Leu Val Gly Met Leu Arg Gln Ser Pro Ala
                  80                  85                  90

 ctg acc acc ctg gat ctc agt ggc tgc caa ctg ccc gcc ccc atg gtg      578
 Leu Thr Thr Leu Asp Leu Ser Gly Cys Gln Leu Pro Ala Pro Met Val
              95                 100                 105

 acc tac ctg tgt gca gtc ctg cag cac cag gga tgc ggc ctg cag acc      626
 Thr Tyr Leu Cys Ala Val Leu Gln His Gln Gly Cys Gly Leu Gln Thr
         110                 115                 120

 ctc agt ctg gcc tct gtg gag ctg agc gag cag tca cta cag gag ctt      674
 Leu Ser Leu Ala Ser Val Glu Leu Ser Glu Gln Ser Leu Gln Glu Leu
     125                 130                 135

 cag gct gtg aag aga gca aag ccg gat ctg gtc atc gca cac cca gcg      722
 Gln Ala Val Lys Arg Ala Lys Pro Asp Leu Val Ile Ala His Pro Ala
 140                 145                 150                 155

 ctg gac ggc cac cca caa cct ccc aag gaa ctc atc tcg acc ttc tga      770
 Leu Asp Gly His Pro Gln Pro Pro Lys Glu Leu Ile Ser Thr Phe 
                 160                 165                 170

 ggctctggtg gccagagcag ggtggaagac cctagtcaaa g                        811




      <210> 254
      <211> 823
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (102)..(725)

      <400> 254
 ccccggggag cccggcgggc gccggcgcgc ccccccccca ccccacgtct cgtcgcgcgc     60

 gcgtccgctg ggggcgggcg gctggcagct gtggcgccga c    atg gct gcg ctg     113
                                                  Met Ala Ala Leu
                                                    1

 gtg gag ccg ctg ggg ctg gag cgg gac gtg tcc cgg gcg gtt gag ctc      161
 Val Glu Pro Leu Gly Leu Glu Arg Asp Val Ser Arg Ala Val Glu Leu
   5                  10                  15                  20

 ctc gag cgg ctc cag cgc agc ggg gag ctg ccg ccg cag aag ctg cag      209
 Leu Glu Arg Leu Gln Arg Ser Gly Glu Leu Pro Pro Gln Lys Leu Gln
                  25                  30                  35

 gcc ctc cag cga gtt ctg cag agc cgc ttc tgc tcc gct atc cga gag      257
 Ala Leu Gln Arg Val Leu Gln Ser Arg Phe Cys Ser Ala Ile Arg Glu
              40                  45                  50

 gtg tat gag cag ctt tat gac acg ctg gac atc acc ggc agc gcc gag      305
 Val Tyr Glu Gln Leu Tyr Asp Thr Leu Asp Ile Thr Gly Ser Ala Glu
          55                  60                  65

 atc cga gcc cat gcc aca gcc aag gcc aca gtg gct gcc ttc aca gcc      353
 Ile Arg Ala His Ala Thr Ala Lys Ala Thr Val Ala Ala Phe Thr Ala
      70                  75                  80

 agc gag ggc cac gca cat ccc agg gta gtg gag cta ccc aag acg gat      401
 Ser Glu Gly His Ala His Pro Arg Val Val Glu Leu Pro Lys Thr Asp
  85                  90                  95                 100

 gag ggc cta ggc ttc aac atc atg ggt ggc aaa gag caa aac tcg ccc      449
 Glu Gly Leu Gly Phe Asn Ile Met Gly Gly Lys Glu Gln Asn Ser Pro
                 105                 110                 115

 atc tac atc tcc cgg gtc atc cca ggg ggt gtg gct gac cgc cat gga      497
 Ile Tyr Ile Ser Arg Val Ile Pro Gly Gly Val Ala Asp Arg His Gly
             120                 125                 130

 ggc ctc aag cgt ggg gat caa ctg ttg tcg gtg aac ggt gtg agc gtt      545
 Gly Leu Lys Arg Gly Asp Gln Leu Leu Ser Val Asn Gly Val Ser Val
         135                 140                 145

 gag ggt gag cag cat gag aag gcg gtg gag ctg ctg aag gcg gcc cag      593
 Glu Gly Glu Gln His Glu Lys Ala Val Glu Leu Leu Lys Ala Ala Gln
     150                 155                 160

 ggc tcg gtg aag ctg gtt gtc cgt tac aca ccg cga gtg ctg gag gag      641
 Gly Ser Val Lys Leu Val Val Arg Tyr Thr Pro Arg Val Leu Glu Glu
 165                 170                 175                 180

 atg gag gcc cgg ttc gag aag atg cgc tct gcc cgc cgg cgc caa cag      689
 Met Glu Ala Arg Phe Glu Lys Met Arg Ser Ala Arg Arg Arg Gln Gln
                 185                 190                 195

 cat cag agc tac tcg tcc ttg gag tct cga ggt tga aacc acagatctgg      739
 His Gln Ser Tyr Ser Ser Leu Glu Ser Arg Gly 
             200                 205

 acgttcacgt gcactctctt cctgtacagt atttattgtt cctggcactt tatttaaaga    799

 tatttgaccc tcaaaaaaaa aaaa                                           823




      <210> 255
      <211> 440
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(440)

      <400> 255
  atg gcg cag cta gag ggt tac tgt ttc tcg gcc gcc ttg agc tgt acc      48
  Met Ala Gln Leu Glu Gly Tyr Cys Phe Ser Ala Ala Leu Ser Cys Thr
    1               5                  10                  15

 ttt tta gtg tcc tgc ctc ctc ttc tcc gcc ttc agc tgg gcg ctg cga       96
 Phe Leu Val Ser Cys Leu Leu Phe Ser Ala Phe Ser Trp Ala Leu Arg
              20                  25                  30

 gag ccc tac atg gac gag atc ttc cac ctg cct cag gcg cag cgc tac      144
 Glu Pro Tyr Met Asp Glu Ile Phe His Leu Pro Gln Ala Gln Arg Tyr
          35                  40                  45

 tgt gag ggc cat ttc tcc ctt tcc cag tgg gat ccc atg att act aca      192
 Cys Glu Gly His Phe Ser Leu Ser Gln Trp Asp Pro Met Ile Thr Thr
      50                  55                  60

 tta cct ggc ttg tac ctg gtg tca gtt gga gtg gtc aaa cct gcc att      240
 Leu Pro Gly Leu Tyr Leu Val Ser Val Gly Val Val Lys Pro Ala Ile
  65                  70                  75                  80

 tgg atc ttt gga tgg tct gaa cat gtt gtc tgc tcc att ggg atg ctc      288
 Trp Ile Phe Gly Trp Ser Glu His Val Val Cys Ser Ile Gly Met Leu
                  85                  90                  95

 aga ttt gtt aat ctt ctc ttc agt gtt ggc aac ttc tat tta cta tat      336
 Arg Phe Val Asn Leu Leu Phe Ser Val Gly Asn Phe Tyr Leu Leu Tyr
             100                 105                 110

 ttg ctt ttc cac aag gta caa ccc aga aac aag gct gcc tca agt atc      384
 Leu Leu Phe His Lys Val Gln Pro Arg Asn Lys Ala Ala Ser Ser Ile
         115                 120                 125

 cag aga gtc ttg tca aca tta aca cta gca gta ttt cca aca ctc tat      432
 Gln Arg Val Leu Ser Thr Leu Thr Leu Ala Val Phe Pro Thr Leu Tyr
     130                 135                 140

 ttt ttt aa                                                           440
 Phe Phe 
 145





      <210> 256
      <211> 3246
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (141)..(1736)

      <220>
      <221> misc_feature
      <222> (1)...(3246)
      <223> n = a,t,c or g

      <400> 256
 ggtgcactga cnctgaggca ctcggcaagg acnnnngggt ngacccacgc gtccgcggac     60

 gcgtgggctc ggagccgttg ggtcggatcc tgctattccg gcgcctccac tccgtccccc    120

 gcgggtctgc tctgtgtgcc    atg gac ggc att gtc cca gat ata gcc gtt     170
                          Met Asp Gly Ile Val Pro Asp Ile Ala Val
                            1               5                  10

 ggt aca aag cgg gga tct gac gag ctt ttc tct act tgt gtc act aac      218
 Gly Thr Lys Arg Gly Ser Asp Glu Leu Phe Ser Thr Cys Val Thr Asn
                  15                  20                  25

 gga ccg ttt atc atg agc agc aac tcg gct tct gca gca aac gga aat      266
 Gly Pro Phe Ile Met Ser Ser Asn Ser Ala Ser Ala Ala Asn Gly Asn
              30                  35                  40

 gac agc aag aag ttc aaa ggt gac agc cga agt gca ggc gtc ccc tct      314
 Asp Ser Lys Lys Phe Lys Gly Asp Ser Arg Ser Ala Gly Val Pro Ser
          45                  50                  55

 aga gtg atc cac atc cgg aag ctc ccc atc gac gtc acg gag ggg gaa      362
 Arg Val Ile His Ile Arg Lys Leu Pro Ile Asp Val Thr Glu Gly Glu
      60                  65                  70

 gtc atc tcc ctg ggg ctg ccc ttt ggg aag gtc acc aac ctc ctg atg      410
 Val Ile Ser Leu Gly Leu Pro Phe Gly Lys Val Thr Asn Leu Leu Met
  75                  80                  85                  90

 ctg aag ggg aaa aac cag gcc ttc atc gag atg aac acg gag gag gct      458
 Leu Lys Gly Lys Asn Gln Ala Phe Ile Glu Met Asn Thr Glu Glu Ala
                  95                 100                 105

 gcc aac acc atg gtg aac tac tac acc tcg gtg acc cct gtg ctg cgc      506
 Ala Asn Thr Met Val Asn Tyr Tyr Thr Ser Val Thr Pro Val Leu Arg
             110                 115                 120

 ggc cag ccc atc tac atc cag ttc tcc aac cac aag gag ctg aag acc      554
 Gly Gln Pro Ile Tyr Ile Gln Phe Ser Asn His Lys Glu Leu Lys Thr
         125                 130                 135

 gac agc tct ccc aac cag gcg cgg gcc cag gcg gcc ctg cag gcg gtg      602
 Asp Ser Ser Pro Asn Gln Ala Arg Ala Gln Ala Ala Leu Gln Ala Val
     140                 145                 150

 aac tcg gtc cag tcg ggg aac ctg gcc ttg gct gcc tcg gcg gcg gcc      650
 Asn Ser Val Gln Ser Gly Asn Leu Ala Leu Ala Ala Ser Ala Ala Ala
 155                 160                 165                 170

 gtg gac gca ggg atg gcg atg gcc ggg cag agc ccc gtg ctc agg atc      698
 Val Asp Ala Gly Met Ala Met Ala Gly Gln Ser Pro Val Leu Arg Ile
                 175                 180                 185

 atc gtg gag aac ctc ttc tac cct gtg acc ctg gat gtg ctg cac cag      746
 Ile Val Glu Asn Leu Phe Tyr Pro Val Thr Leu Asp Val Leu His Gln
             190                 195                 200

 att ttc tcc aag ttc ggc aca gtg ttg aag atc atc acc ttc acc aag      794
 Ile Phe Ser Lys Phe Gly Thr Val Leu Lys Ile Ile Thr Phe Thr Lys
         205                 210                 215

 aac aac cag ttc cag gcc ctg ctg cag tat gcg gac ccc gtg agc gcc      842
 Asn Asn Gln Phe Gln Ala Leu Leu Gln Tyr Ala Asp Pro Val Ser Ala
     220                 225                 230

 cag cac gcc aag ctg tcg ctg gac ggg cag aac atc tac aac gcc tgc      890
 Gln His Ala Lys Leu Ser Leu Asp Gly Gln Asn Ile Tyr Asn Ala Cys
 235                 240                 245                 250

 tgc acg ctg cgc atc gac ttt tcc aag ctc acc agc ctc aac gtc aag      938
 Cys Thr Leu Arg Ile Asp Phe Ser Lys Leu Thr Ser Leu Asn Val Lys
                 255                 260                 265

 tac aac aat gac aag agc cgt gac tac aca cgc cca gac ctg cct tcc      986
 Tyr Asn Asn Asp Lys Ser Arg Asp Tyr Thr Arg Pro Asp Leu Pro Ser
             270                 275                 280

 ggg gac agc cag ccc tcg ctg gac cag acc atg gcc gcg gcc ttc ggc     1034
 Gly Asp Ser Gln Pro Ser Leu Asp Gln Thr Met Ala Ala Ala Phe Gly
         285                 290                 295

 ctt tcc gtt ccg aac gtc cac ggc gcc ctg gcc ccc ctg gcc atc ccc     1082
 Leu Ser Val Pro Asn Val His Gly Ala Leu Ala Pro Leu Ala Ile Pro
     300                 305                 310

 tcg gcg gcg gcg gca gct gcg gcg gca ggt cgg atc gcc atc ccg ggc     1130
 Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Ile Ala Ile Pro Gly
 315                 320                 325                 330

 ctg gcg ggg gca gga aat tct gta ttg ctg gtc agc aac ctc aac cca     1178
 Leu Ala Gly Ala Gly Asn Ser Val Leu Leu Val Ser Asn Leu Asn Pro
                 335                 340                 345

 gag aga gtc aca ccc caa agc ctc ttt att ctt ttc ggc gtc tac ggt     1226
 Glu Arg Val Thr Pro Gln Ser Leu Phe Ile Leu Phe Gly Val Tyr Gly
             350                 355                 360

 gac gtg cag cgc gtg aag atc ctg ttc aat aag aag gag aac gcc cta     1274
 Asp Val Gln Arg Val Lys Ile Leu Phe Asn Lys Lys Glu Asn Ala Leu
         365                 370                 375

 gtg cag atg gcg gac ggc aac cag gcc cag ctg gcc atg agc cac ctg     1322
 Val Gln Met Ala Asp Gly Asn Gln Ala Gln Leu Ala Met Ser His Leu
     380                 385                 390

 aac ggg cac aag ctg cac ggg aag ccc atc cgc atc acg ctc tcg aag     1370
 Asn Gly His Lys Leu His Gly Lys Pro Ile Arg Ile Thr Leu Ser Lys
 395                 400                 405                 410

 cac cag aac gtg cag ctg ccc cgc gag ggc cag gag gac cag ggc ctg     1418
 His Gln Asn Val Gln Leu Pro Arg Glu Gly Gln Glu Asp Gln Gly Leu
                 415                 420                 425

 acc aag gac tac ggc aac tca ccc ctg cac cgc ttc aag aag ccg ggc     1466
 Thr Lys Asp Tyr Gly Asn Ser Pro Leu His Arg Phe Lys Lys Pro Gly
             430                 435                 440

 tcc aag aac ttc cag aac ata ttc ccg ccc tcg gcc acg ctg cac ctc     1514
 Ser Lys Asn Phe Gln Asn Ile Phe Pro Pro Ser Ala Thr Leu His Leu
         445                 450                 455

 tcc aac atc ccg ccc tca gtc tcc gag gag gat ctc aag gtc ctg ttt     1562
 Ser Asn Ile Pro Pro Ser Val Ser Glu Glu Asp Leu Lys Val Leu Phe
     460                 465                 470

 tcc agc aat ggg ggc gtc gtc aaa gga ttc aag ttc ttc cag aag gac     1610
 Ser Ser Asn Gly Gly Val Val Lys Gly Phe Lys Phe Phe Gln Lys Asp
 475                 480                 485                 490

 cgc aag atg gca ctg atc cag atg ggc tcc gtg gag gag gcg gtc cag     1658
 Arg Lys Met Ala Leu Ile Gln Met Gly Ser Val Glu Glu Ala Val Gln
                 495                 500                 505

 gcc ctc att gac ctg cac aac cac gac ctc ggg gag aac cac cac ctg     1706
 Ala Leu Ile Asp Leu His Asn His Asp Leu Gly Glu Asn His His Leu
             510                 515                 520

 cgg gtc tcc ttc tcc aag tcc acc atc tag g ggcacaggcc cccacggccg     1757
 Arg Val Ser Phe Ser Lys Ser Thr Ile 
         525                 530

 gggccccctg gcgacaactt ccatcattcc agagaaaagc cactttaaaa acagctgaag   1817

 tgaccttagc agaccagaga ttttattttt ttaaagagaa atcagtttac ctgtttttaa   1877

 aaaaattaaa tctagttcac cttgctcacc ctgcggtgac agggacagct caggctcttg   1937

 gtgactgtgg cagcgggagt tcccggccct ccacacccgg ggccagaccc tcggggccat   1997

 gccttggtgg ggcctgtgtc gggcgtgggg cctgcaggtg ggcgccccga ccacgacttg   2057

 gcttccttgt gccttaaaaa acctgccttc ctgcagccac acacccaccc ggggtgtcct   2117

 ggggacccaa ggggtggggg ggtcacacca gagagaggca gggggcctgg ccggctcctg   2177

 caggatcatg cagctggggc cgcggcggcc gcggctgcga gcaccccaac cccagccctc   2237

 taatcaagtc acgtgattct cccttcaccc cgcccccagg gccttccctt ctgcccccag   2297

 gcgggctccc cgctgctcca gctgcggagc tggtcgacat aatctctgta ttatatactt   2357

 tgcagttgca gacgtctgtg cctagcaata tttccagttg accaaatatt ctaatctttt   2417

 ttcatttata tgcaaaagaa atagttttaa gtaacttttt atagcaagat gatacaatgg   2477

 tatgagtgta atctaaactt ccttgtggta ttaccttgta tgctgttact tttattttat   2537

 tccttgtaat taagtcacag gcaggaccca gtttccagag agcaggcggg gccgcccagt   2597

 gggtcaggca cagggagccc cggtcctatc ttagagcccc tgagcttcag ggaaggggcg   2657

 ggcgtgtcgc cgcctctggc atcgcctccg gttgccttac accacgcctt cacctgcagt   2717

 cgcctagaaa acttgctctc aaacttcagg gttttttctt ccttcaaatt ttggaccaaa   2777

 gtctcatttc tgtgttttgc ctgcctctga tgctgggacc cggaaggcgg gcgctcctcc   2837

 tgtcttctct gtgctctttc taccgccccc gcgtcctgtc ccgggggctc tcctaggatc   2897

 ccctttccgt aaaagcgtgt aacaagggtg taaatattta taatttttta tacctgttgt   2957

 gagacccgag gggcggcggc gcggtttttt atggtgacac aaatgtatat tttgctaaca   3017

 gcaattccag gctcagtatt gtgaccgcgg agccacaggg gaccccacgc acattccgtt   3077

 gccttacccg atggcttgtg acgcggagag aaccgattaa aaccgtttga gaaactcctc   3137

 ccttgtctag ccctgtgttc gctgtggacg ctgtagaggc aggttggcca gtctgtacct   3197

 ggacttcgaa taaatcttct gtatcctcgc tccgttcaaa aaaaaaaaa               3246




      <210> 257
      <211> 2345
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (190)..(1854)

      <220>
      <221> misc_feature
      <222> (1)...(2345)
      <223> n = a,t,c or g

      <400> 257
 cctctatatg catgctcgag cgcggncgca gtgtgatgga tatctgcaga attcggctta     60

 ctcactatag ggctcgagcg gccgcccggg caggtgagga gagaggaggc ggcggcttag    120

 ctgctacggg gtccgggccg gcgccctccc gaggggggct caggaggagg aaggaggacc    180

 cgtgcgaga    atg cct ctg ccc tgg agc ctt gcg ctc ccg ctg ctg ctc     228
              Met Pro Leu Pro Trp Ser Leu Ala Leu Pro Leu Leu Leu
                1               5                  10

 tcc tgg gtg gca ggt ggt ttc ggg aac gcg gcc agt gca agg cat cat      276
 Ser Trp Val Ala Gly Gly Phe Gly Asn Ala Ala Ser Ala Arg His His
      15                  20                  25

 cac ggg ttg tta gca tcg gca cgt cag cct ggg gtc tgt cac tat gga      324
 His Gly Leu Leu Ala Ser Ala Arg Gln Pro Gly Val Cys His Tyr Gly
  30                  35                  40                  45

 act aaa ctg gcc tgc tgc tac ggc tgg aga aga aac agc aag gga gtc      372
 Thr Lys Leu Ala Cys Cys Tyr Gly Trp Arg Arg Asn Ser Lys Gly Val
                  50                  55                  60

 tgt gaa gct aca tgc gaa cct gga tgt aag ttt ggt gag tgc gtg gga      420
 Cys Glu Ala Thr Cys Glu Pro Gly Cys Lys Phe Gly Glu Cys Val Gly
              65                  70                  75

 cca aac aaa tgc aga tgc ttt cca gga tac acc ggg aaa acc tgc agt      468
 Pro Asn Lys Cys Arg Cys Phe Pro Gly Tyr Thr Gly Lys Thr Cys Ser
          80                  85                  90

 caa gat gtg aat gag tgt gga atg aaa ccc cgg cca tgc caa cac aga      516
 Gln Asp Val Asn Glu Cys Gly Met Lys Pro Arg Pro Cys Gln His Arg
      95                 100                 105

 tgt gtg aat aca cac gga agc tac aag tgc ttt tgc ctc agt ggc cac      564
 Cys Val Asn Thr His Gly Ser Tyr Lys Cys Phe Cys Leu Ser Gly His
 110                 115                 120                 125

 atg ctc atg cca gat gct acg tgt gtg aac tct agg aca tgt gcc atg      612
 Met Leu Met Pro Asp Ala Thr Cys Val Asn Ser Arg Thr Cys Ala Met
                 130                 135                 140

 ata aac tgt cag tac agc tgt gaa gac aca gaa gaa ggg cca cag tgc      660
 Ile Asn Cys Gln Tyr Ser Cys Glu Asp Thr Glu Glu Gly Pro Gln Cys
             145                 150                 155

 ctg tgt cca tcc tca gga ctc cgc ctg gcc cca aat gga aga gac tgt      708
 Leu Cys Pro Ser Ser Gly Leu Arg Leu Ala Pro Asn Gly Arg Asp Cys
         160                 165                 170

 cta gat att gat gaa tgt gcc tct ggt aaa gtc atc tgt ccc tac aat      756
 Leu Asp Ile Asp Glu Cys Ala Ser Gly Lys Val Ile Cys Pro Tyr Asn
     175                 180                 185

 cga aga tgt gtg aac aca ttt gga agc tac tac tgc aaa tgt cac att      804
 Arg Arg Cys Val Asn Thr Phe Gly Ser Tyr Tyr Cys Lys Cys His Ile
 190                 195                 200                 205

 ggt ttc gaa ctg caa tat atc agt gga cga tat gac tgt ata gat ata      852
 Gly Phe Glu Leu Gln Tyr Ile Ser Gly Arg Tyr Asp Cys Ile Asp Ile
                 210                 215                 220

 aat gaa tgt act atg gat agc cat acg tgc agc cac cat gcc aat tgc      900
 Asn Glu Cys Thr Met Asp Ser His Thr Cys Ser His His Ala Asn Cys
             225                 230                 235

 ttc aat acc caa ggg tcc ttc aag tgt aaa tgc aag cag gga tat aaa      948
 Phe Asn Thr Gln Gly Ser Phe Lys Cys Lys Cys Lys Gln Gly Tyr Lys
         240                 245                 250

 ggc aat gga ctt cgg tgt tct gct atc cct gaa aat tct gtg aag gaa      996
 Gly Asn Gly Leu Arg Cys Ser Ala Ile Pro Glu Asn Ser Val Lys Glu
     255                 260                 265

 gtc ctc aga gca cct ggt acc atc aaa gac aga atc aag aag ttg ctt     1044
 Val Leu Arg Ala Pro Gly Thr Ile Lys Asp Arg Ile Lys Lys Leu Leu
 270                 275                 280                 285

 gct cac aaa aac agt atg aaa aag aag gca aaa att aaa aat gtt acc     1092
 Ala His Lys Asn Ser Met Lys Lys Lys Ala Lys Ile Lys Asn Val Thr
                 290                 295                 300

 cca gaa ccc acc agg act cct acc cct aag gtg aac ttg cag ccc ttc     1140
 Pro Glu Pro Thr Arg Thr Pro Thr Pro Lys Val Asn Leu Gln Pro Phe
             305                 310                 315

 aac tat gaa gag ata gtt tcc aga ggc ggg aac tct cat gga ggt aaa     1188
 Asn Tyr Glu Glu Ile Val Ser Arg Gly Gly Asn Ser His Gly Gly Lys
         320                 325                 330

 aaa ggg aat gaa gag aaa atg aaa gag ggg ctt gag gat gag aaa aga     1236
 Lys Gly Asn Glu Glu Lys Met Lys Glu Gly Leu Glu Asp Glu Lys Arg
     335                 340                 345

 gaa gag aaa gcc ctg aag aat gac ata gag gag cga agc ctg cga gga     1284
 Glu Glu Lys Ala Leu Lys Asn Asp Ile Glu Glu Arg Ser Leu Arg Gly
 350                 355                 360                 365

 gat gtg ttt ttc cct aag gtg aat gaa gca ggt gaa ttc ggc ctg att     1332
 Asp Val Phe Phe Pro Lys Val Asn Glu Ala Gly Glu Phe Gly Leu Ile
                 370                 375                 380

 ctg gtc caa agg aaa gcg cta act tcc aaa ctg gaa cat aaa gat tta     1380
 Leu Val Gln Arg Lys Ala Leu Thr Ser Lys Leu Glu His Lys Asp Leu
             385                 390                 395

 aat atc tcg gtt gac tgc agc ttc aat cat ggg atc tgt gac tgg aaa     1428
 Asn Ile Ser Val Asp Cys Ser Phe Asn His Gly Ile Cys Asp Trp Lys
         400                 405                 410

 cag gat aga gaa gat gat ttt gac tgg aat cct gct gat cga gat aat     1476
 Gln Asp Arg Glu Asp Asp Phe Asp Trp Asn Pro Ala Asp Arg Asp Asn
     415                 420                 425

 gct att ggc ttc tat atg gca gtt ccg gcc ttg gca ggt cac aag aaa     1524
 Ala Ile Gly Phe Tyr Met Ala Val Pro Ala Leu Ala Gly His Lys Lys
 430                 435                 440                 445

 gac att ggc cga ttg aaa ctt ctc cta cct gac ctg caa ccc caa agc     1572
 Asp Ile Gly Arg Leu Lys Leu Leu Leu Pro Asp Leu Gln Pro Gln Ser
                 450                 455                 460

 aac ttc tgt ttg ctc ttt gat tac cgg ctg gcc gga gac aaa gtc ggg     1620
 Asn Phe Cys Leu Leu Phe Asp Tyr Arg Leu Ala Gly Asp Lys Val Gly
             465                 470                 475

 aaa ctt cga gtg ttt gtg aaa aac agt aac aat gcc ctg gca tgg gag     1668
 Lys Leu Arg Val Phe Val Lys Asn Ser Asn Asn Ala Leu Ala Trp Glu
         480                 485                 490

 aag acc acg agt gag gat gaa aag tgg aag aca ggg aaa att cag ttg     1716
 Lys Thr Thr Ser Glu Asp Glu Lys Trp Lys Thr Gly Lys Ile Gln Leu
     495                 500                 505

 tat caa gga act gat gct acc aaa agc atc att ttt gaa gca gaa cgt     1764
 Tyr Gln Gly Thr Asp Ala Thr Lys Ser Ile Ile Phe Glu Ala Glu Arg
 510                 515                 520                 525

 ggc aag ggc aaa acc ggc gaa atc gca gtg gat ggc gtc ttg ctt gtt     1812
 Gly Lys Gly Lys Thr Gly Glu Ile Ala Val Asp Gly Val Leu Leu Val
                 530                 535                 540

 tca ggc tta tgt cca gat agc ctt tta tct gtg gat gac tga atgttac     1861
 Ser Gly Leu Cys Pro Asp Ser Leu Leu Ser Val Asp Asp 
             545                 550

 tatctttata tttgactttg tatgtcagtt ccctggtttt tttgatattg catcatagga   1921

 cctctggcat tttagaatta ctagctgaaa aattgtaatg taccaacaga aatattattg   1981

 taagatgcct ttcttgtata agatatgcca atatttgctt taaatatcat atcactgtat   2041

 cttctcagtc atttctgaat ctttccacat tatattataa aatatggaaa tgtcagttta   2101

 tctcccctcc tcagtatatc tgatttgtat aagtaagttg atgagcttct ctctacaaca   2161

 tttctagaaa atagaaaaaa aagcacagag aaatgtttaa ctgtttgact cttatgatac   2221

 ttcttggaaa ctatgacatc aaagatagac ttttgcctaa gtggcttagc tgggtctttc   2281

 atagccaaac ttgtatattt aaattctttg taataataat atccaaatca tcaaaaaaaa   2341

 aaaa                                                                2345




      <210> 258
      <211> 2360
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (190)..(1869)

      <220>
      <221> misc_feature
      <222> (1)...(2360)
      <223> n = a,t,c or g

      <400> 258
 cctctatatg catgctcgag cgcggncgca gtgtgatgga tatctgcaga attcggctta     60

 ctcactatag ggctcgagcg gccgcccggg caggtgagga gagaggaggc ggcggcttag    120

 ctgctacggg gtccgggccg gcgccctccc gaggggggct caggaggagg aaggaggacc    180

 cgtgcgaga    atg cct ctg ccc tgg agc ctt gcg ctc ccg ctg ctg ctc     228
              Met Pro Leu Pro Trp Ser Leu Ala Leu Pro Leu Leu Leu
                1               5                  10

 tcc tgg gtg gca ggt ggt ttc ggg aac gcg gcc agt gca agg ggt tct      276
 Ser Trp Val Ala Gly Gly Phe Gly Asn Ala Ala Ser Ala Arg Gly Ser
      15                  20                  25

 cat cat cat cat cat cac ggg ttg tta gca tcg gca cgt cag cct ggg      324
 His His His His His His Gly Leu Leu Ala Ser Ala Arg Gln Pro Gly
  30                  35                  40                  45

 gtc tgt cac tat gga act aaa ctg gcc tgc tgc tac ggc tgg aga aga      372
 Val Cys His Tyr Gly Thr Lys Leu Ala Cys Cys Tyr Gly Trp Arg Arg
                  50                  55                  60

 aac agc aag gga gtc tgt gaa gct aca tgc gaa cct gga tgt aag ttt      420
 Asn Ser Lys Gly Val Cys Glu Ala Thr Cys Glu Pro Gly Cys Lys Phe
              65                  70                  75

 ggt gag tgc gtg gga cca aac aaa tgc aga tgc ttt cca gga tac acc      468
 Gly Glu Cys Val Gly Pro Asn Lys Cys Arg Cys Phe Pro Gly Tyr Thr
          80                  85                  90

 ggg aaa acc tgc agt caa gat gtg aat gag tgt gga atg aaa ccc cgg      516
 Gly Lys Thr Cys Ser Gln Asp Val Asn Glu Cys Gly Met Lys Pro Arg
      95                 100                 105

 cca tgc caa cac aga tgt gtg aat aca cac gga agc tac aag tgc ttt      564
 Pro Cys Gln His Arg Cys Val Asn Thr His Gly Ser Tyr Lys Cys Phe
 110                 115                 120                 125

 tgc ctc agt ggc cac atg ctc atg cca gat gct acg tgt gtg aac tct      612
 Cys Leu Ser Gly His Met Leu Met Pro Asp Ala Thr Cys Val Asn Ser
                 130                 135                 140

 agg aca tgt gcc atg ata aac tgt cag tac agc tgt gaa gac aca gaa      660
 Arg Thr Cys Ala Met Ile Asn Cys Gln Tyr Ser Cys Glu Asp Thr Glu
             145                 150                 155

 gaa ggg cca cag tgc ctg tgt cca tcc tca gga ctc cgc ctg gcc cca      708
 Glu Gly Pro Gln Cys Leu Cys Pro Ser Ser Gly Leu Arg Leu Ala Pro
         160                 165                 170

 aat gga aga gac tgt cta gat att gat gaa tgt gcc tct ggt aaa gtc      756
 Asn Gly Arg Asp Cys Leu Asp Ile Asp Glu Cys Ala Ser Gly Lys Val
     175                 180                 185

 atc tgt ccc tac aat cga aga tgt gtg aac aca ttt gga agc tac tac      804
 Ile Cys Pro Tyr Asn Arg Arg Cys Val Asn Thr Phe Gly Ser Tyr Tyr
 190                 195                 200                 205

 tgc aaa tgt cac att ggt ttc gaa ctg caa tat atc agt gga cga tat      852
 Cys Lys Cys His Ile Gly Phe Glu Leu Gln Tyr Ile Ser Gly Arg Tyr
                 210                 215                 220

 gac tgt ata gat ata aat gaa tgt act atg gat agc cat acg tgc agc      900
 Asp Cys Ile Asp Ile Asn Glu Cys Thr Met Asp Ser His Thr Cys Ser
             225                 230                 235

 cac cat gcc aat tgc ttc aat acc caa ggg tcc ttc aag tgt aaa tgc      948
 His His Ala Asn Cys Phe Asn Thr Gln Gly Ser Phe Lys Cys Lys Cys
         240                 245                 250

 aag cag gga tat aaa ggc aat gga ctt cgg tgt tct gct atc cct gaa      996
 Lys Gln Gly Tyr Lys Gly Asn Gly Leu Arg Cys Ser Ala Ile Pro Glu
     255                 260                 265

 aat tct gtg aag gaa gtc ctc aga gca cct ggt acc atc aaa gac aga     1044
 Asn Ser Val Lys Glu Val Leu Arg Ala Pro Gly Thr Ile Lys Asp Arg
 270                 275                 280                 285

 atc aag aag ttg ctt gct cac aaa aac agt atg aaa aag aag gca aaa     1092
 Ile Lys Lys Leu Leu Ala His Lys Asn Ser Met Lys Lys Lys Ala Lys
                 290                 295                 300

 att aaa aat gtt acc cca gaa ccc acc agg act cct acc cct aag gtg     1140
 Ile Lys Asn Val Thr Pro Glu Pro Thr Arg Thr Pro Thr Pro Lys Val
             305                 310                 315

 aac ttg cag ccc ttc aac tat gaa gag ata gtt tcc aga ggc ggg aac     1188
 Asn Leu Gln Pro Phe Asn Tyr Glu Glu Ile Val Ser Arg Gly Gly Asn
         320                 325                 330

 tct cat gga ggt aaa aaa ggg aat gaa gag aaa atg aaa gag ggg ctt     1236
 Ser His Gly Gly Lys Lys Gly Asn Glu Glu Lys Met Lys Glu Gly Leu
     335                 340                 345

 gag gat gag aaa aga gaa gag aaa gcc ctg aag aat gac ata gag gag     1284
 Glu Asp Glu Lys Arg Glu Glu Lys Ala Leu Lys Asn Asp Ile Glu Glu
 350                 355                 360                 365

 cga agc ctg cga gga gat gtg ttt ttc cct aag gtg aat gaa gca ggt     1332
 Arg Ser Leu Arg Gly Asp Val Phe Phe Pro Lys Val Asn Glu Ala Gly
                 370                 375                 380

 gaa ttc ggc ctg att ctg gtc caa agg aaa gcg cta act tcc aaa ctg     1380
 Glu Phe Gly Leu Ile Leu Val Gln Arg Lys Ala Leu Thr Ser Lys Leu
             385                 390                 395

 gaa cat aaa gat tta aat atc tcg gtt gac tgc agc ttc aat cat ggg     1428
 Glu His Lys Asp Leu Asn Ile Ser Val Asp Cys Ser Phe Asn His Gly
         400                 405                 410

 atc tgt gac tgg aaa cag gat aga gaa gat gat ttt gac tgg aat cct     1476
 Ile Cys Asp Trp Lys Gln Asp Arg Glu Asp Asp Phe Asp Trp Asn Pro
     415                 420                 425

 gct gat cga gat aat gct att ggc ttc tat atg gca gtt ccg gcc ttg     1524
 Ala Asp Arg Asp Asn Ala Ile Gly Phe Tyr Met Ala Val Pro Ala Leu
 430                 435                 440                 445

 gca ggt cac aag aaa gac att ggc cga ttg aaa ctt ctc cta cct gac     1572
 Ala Gly His Lys Lys Asp Ile Gly Arg Leu Lys Leu Leu Leu Pro Asp
                 450                 455                 460

 ctg caa ccc caa agc aac ttc tgt ttg ctc ttt gat tac cgg ctg gcc     1620
 Leu Gln Pro Gln Ser Asn Phe Cys Leu Leu Phe Asp Tyr Arg Leu Ala
             465                 470                 475

 gga gac aaa gtc ggg aaa ctt cga gtg ttt gtg aaa aac agt aac aat     1668
 Gly Asp Lys Val Gly Lys Leu Arg Val Phe Val Lys Asn Ser Asn Asn
         480                 485                 490

 gcc ctg gca tgg gag aag acc acg agt gag gat gaa aag tgg aag aca     1716
 Ala Leu Ala Trp Glu Lys Thr Thr Ser Glu Asp Glu Lys Trp Lys Thr
     495                 500                 505

 ggg aaa att cag ttg tat caa gga act gat gct acc aaa agc atc att     1764
 Gly Lys Ile Gln Leu Tyr Gln Gly Thr Asp Ala Thr Lys Ser Ile Ile
 510                 515                 520                 525

 ttt gaa gca gaa cgt ggc aag ggc aaa acc ggc gaa atc gca gtg gat     1812
 Phe Glu Ala Glu Arg Gly Lys Gly Lys Thr Gly Glu Ile Ala Val Asp
                 530                 535                 540

 ggc gtc ttg ctt gtt tca ggc tta tgt cca gat agc ctt tta tct gtg     1860
 Gly Val Leu Leu Val Ser Gly Leu Cys Pro Asp Ser Leu Leu Ser Val
             545                 550                 555

 gat gac tga atgttac tatctttata tttgactttg tatgtcagtt ccctggtttt     1916
 Asp Asp 


 tttgatattg catcatagga cctctggcat tttagaatta ctagctgaaa aattgtaatg   1976

 taccaacaga aatattattg taagatgcct ttcttgtata agatatgcca atatttgctt   2036

 taaatatcat atcactgtat cttctcagtc atttctgaat ctttccacat tatattataa   2096

 aatatggaaa tgtcagttta tctcccctcc tcagtatatc tgatttgtat aagtaagttg   2156

 atgagcttct ctctacaaca tttctagaaa atagaaaaaa aagcacagag aaatgtttaa   2216

 ctgtttgact cttatgatac ttcttggaaa ctatgacatc aaagatagac ttttgcctaa   2276

 gtggcttagc tgggtctttc atagccaaac ttgtatattt aaattctttg taataataat   2336

 atccaaatca tcaaaaaaaa aaaa                                          2360




      <210> 259
      <211> 3756
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (37)..(3444)

      <400> 259
 atgttttata agtattgaca ttacacagtg ttaaca  atg cat cca cag agc ttg      54
                                          Met His Pro Gln Ser Leu
                                            1               5

 gct gaa gag gaa ata aaa aca gaa cag gag gtg gta gag ggc atg gat      102
 Ala Glu Glu Glu Ile Lys Thr Glu Gln Glu Val Val Glu Gly Met Asp
              10                  15                  20

 atc tct act cgc tcc aaa gat cct ggc tct gca gag aga aca gcc cag      150
 Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser Ala Glu Arg Thr Ala Gln
          25                  30                  35

 aaa aga aag ttc ccc agc cct cca cat tct tcc aat ggc cac tcg ccg      198
 Lys Arg Lys Phe Pro Ser Pro Pro His Ser Ser Asn Gly His Ser Pro
      40                  45                  50

 cag gac aca tca aca agc ccc att aaa aag aaa aag aaa cct ggc tta      246
 Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys Lys Lys Lys Pro Gly Leu
  55                  60                  65                  70

 ctg aac agt aac aat aag gag cag gat gga cgg aat gat ttc tac tgc      294
 Leu Asn Ser Asn Asn Lys Glu Gln Asp Gly Arg Asn Asp Phe Tyr Cys
                  75                  80                  85

 tgg gtt tgt cac cgg gaa ggc caa gtc ctt tgc tgt gag ctc tgt ccc      342
 Trp Val Cys His Arg Glu Gly Gln Val Leu Cys Cys Glu Leu Cys Pro
              90                  95                 100

 cgg gtt tat cac gct aag tgt ctg aga ctg aca tcg gaa cca gag ggg      390
 Arg Val Tyr His Ala Lys Cys Leu Arg Leu Thr Ser Glu Pro Glu Gly
         105                 110                 115

 gac tgg ttt tgt cct gaa tgt gag aaa att aca gta gca gaa tgc atc      438
 Asp Trp Phe Cys Pro Glu Cys Glu Lys Ile Thr Val Ala Glu Cys Ile
     120                 125                 130

 gag acc cag agt aaa gcc atg aca atg ctc acc att gaa cag tta tcc      486
 Glu Thr Gln Ser Lys Ala Met Thr Met Leu Thr Ile Glu Gln Leu Ser
 135                 140                 145                 150

 tac ctg ctc aag ttt gcc att cag aaa atg aaa cag cca ggg aca gat      534
 Tyr Leu Leu Lys Phe Ala Ile Gln Lys Met Lys Gln Pro Gly Thr Asp
                 155                 160                 165

 gca ttc cag aag ccc gtt cca ttg gaa cag cac cct gac tat gcg gaa      582
 Ala Phe Gln Lys Pro Val Pro Leu Glu Gln His Pro Asp Tyr Ala Glu
             170                 175                 180

 tac atc ttc cat cca atg gac ctt tgt aca ttg gaa aag aat gcg aaa      630
 Tyr Ile Phe His Pro Met Asp Leu Cys Thr Leu Glu Lys Asn Ala Lys
         185                 190                 195

 aag aaa atg tat ggc tgc aca gaa gcc ttc ctg gct gat gca aag tgg      678
 Lys Lys Met Tyr Gly Cys Thr Glu Ala Phe Leu Ala Asp Ala Lys Trp
     200                 205                 210

 att ttg cac aac tgc atc att tat aat ggg gga aat cac aaa ttg acg      726
 Ile Leu His Asn Cys Ile Ile Tyr Asn Gly Gly Asn His Lys Leu Thr
 215                 220                 225                 230

 caa ata gcg aaa gta gtc atc aaa atc tgt gaa cat gag atg aat gaa      774
 Gln Ile Ala Lys Val Val Ile Lys Ile Cys Glu His Glu Met Asn Glu
                 235                 240                 245

 atc gaa gta tgt cca gaa tgt tat cta gct gct tgc caa aaa cga gat      822
 Ile Glu Val Cys Pro Glu Cys Tyr Leu Ala Ala Cys Gln Lys Arg Asp
             250                 255                 260

 aac tgg ttt tgt gag cct tgt agc aat cca cat cct ttg gtc tgg gcc      870
 Asn Trp Phe Cys Glu Pro Cys Ser Asn Pro His Pro Leu Val Trp Ala
         265                 270                 275

 aaa ctg aag ggg ttt cca ttc tgg cct gca aaa gct cta agg gat aaa      918
 Lys Leu Lys Gly Phe Pro Phe Trp Pro Ala Lys Ala Leu Arg Asp Lys
     280                 285                 290

 gac ggg cag gtc gat gcc cga ttc ttt gga caa cat gac agg gcc tgg      966
 Asp Gly Gln Val Asp Ala Arg Phe Phe Gly Gln His Asp Arg Ala Trp
 295                 300                 305                 310

 gtt cca ata aat aat tgc tac ctc atg tct aaa gaa att cct ttt tct     1014
 Val Pro Ile Asn Asn Cys Tyr Leu Met Ser Lys Glu Ile Pro Phe Ser
                 315                 320                 325

 gtg aaa aag act aag agc atc ttc aac agt gcc atg caa gag atg gag     1062
 Val Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu
             330                 335                 340

 gtt tac gtg gag aac atc cgc agg aag ttt ggg gtt ttt aat tac tct     1110
 Val Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser
         345                 350                 355

 cca ttt agg aca ccc tac aca ccc aac agc cag tat caa atg ctg ctc     1158
 Pro Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu
     360                 365                 370

 gat ccc acc aac ccc agc gcc ggc act gcc aag ata gac aag cag gag     1206
 Asp Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu
 375                 380                 385                 390

 aag gtc aag ctc aac ttt gac atg acg gca tcc ccc aag atc ctg atg     1254
 Lys Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met
                 395                 400                 405

 agc aag cct gtg ctg agt ggg ggc aca ggc cgc cgg att tcc ttg tcg     1302
 Ser Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser
             410                 415                 420

 gat atg ccg cgc tcc ccc atg agc aca aac tct tct gtg cac acg ggc     1350
 Asp Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly
         425                 430                 435

 tcc gac gtg gag cag gat gct gag aag aag gcc acg tcg agc cac ttc     1398
 Ser Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe
     440                 445                 450

 agt gcg agc gag gag tcc atg gac ttc ctg gat aag agc aca gct tca     1446
 Ser Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser
 455                 460                 465                 470

 cca gcc tcc acc aag acg gga caa gca ggg agt tta tcc ggc agc cca     1494
 Pro Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro
                 475                 480                 485

 aag ccc ttc tct cct caa ctg tca gct cct atc acg acg aaa acg gac     1542
 Lys Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp
             490                 495                 500

 aaa acc tcc acc acc ggc agc atc ctg aat ctt aac ctg gat cga agc     1590
 Lys Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser
         505                 510                 515

 aaa gct gag atg gat ttg aag gag ctg agc gag tcg gtc cag caa cag     1638
 Lys Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln
     520                 525                 530

 tcc acc cct gtt cct ctc atc tct ccc aag cgc cag att cgt agc agg     1686
 Ser Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg
 535                 540                 545                 550

 ttc cag ctg aat ctt gac aag acc ata gag agt tgc aaa gca caa tta     1734
 Phe Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu
                 555                 560                 565

 ggc ata aat gaa atc tcg gaa gat gtc tat acg gcc gta gag cac agc     1782
 Gly Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser
             570                 575                 580

 gat tcg gag gat tct gag aag tca gat agt agc gat agt gag tat atc     1830
 Asp Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile
         585                 590                 595

 agt gat gat gag cag aag tct aag aac gag cca gaa gac aca gag gac     1878
 Ser Asp Asp Glu Gln Lys Ser Lys Asn Glu Pro Glu Asp Thr Glu Asp
     600                 605                 610

 aaa gaa ggt tgt cag atg gac aaa gag cca tct gct gtt aaa aaa aag     1926
 Lys Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val Lys Lys Lys
 615                 620                 625                 630

 ccc aag cct aca aac cca gtg gag att aaa gag gag ctg aaa agc acg     1974
 Pro Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu Lys Ser Thr
                 635                 640                 645

 tca cca gcc agc gag aag gca gac cct gga gca gtc aag gac aag gcc     2022
 Ser Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys Asp Lys Ala
             650                 655                 660

 agc cct gag cct gag aag gac ttt tcc gaa aag gca aaa cct tca cct     2070
 Ser Pro Glu Pro Glu Lys Asp Phe Ser Glu Lys Ala Lys Pro Ser Pro
         665                 670                 675

 cac ccc ata aag gat aaa ctg aag gga aaa gat gag acg gat tcc cca     2118
 His Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser Pro
     680                 685                 690

 aca gtc cat ttg ggc ctg gac tct gat tca gag agc gaa ctt gtc ata     2166
 Thr Val His Leu Gly Leu Asp Ser Asp Ser Glu Ser Glu Leu Val Ile
 695                 700                 705                 710

 gat tta gga gaa gac cat tct ggg cgg gag ggt cga aaa aat aag aag     2214
 Asp Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys Asn Lys Lys
                 715                 720                 725

 gaa ccc aaa gaa cca tct ccc aaa cag gat gtt gta ggt aaa act cca     2262
 Glu Pro Lys Glu Pro Ser Pro Lys Gln Asp Val Val Gly Lys Thr Pro
             730                 735                 740

 cca tcc acg acg gtg ggc agc cat tct ccc ccg gaa aca ccg gtg ctc     2310
 Pro Ser Thr Thr Val Gly Ser His Ser Pro Pro Glu Thr Pro Val Leu
         745                 750                 755

 acc cgc tct tcc gcc caa act tcc gcg gct ggc gcc aca gcc acc acc     2358
 Thr Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr Thr
     760                 765                 770

 agc acg tcc tcc acg gtc acc gtc acg gcc ccg gcc ccc gcc gcc aca     2406
 Ser Thr Ser Ser Thr Val Thr Val Thr Ala Pro Ala Pro Ala Ala Thr
 775                 780                 785                 790

 gga agc cca gtg aaa aag cag agg ccg ctt tta ccg aag gag act gcc     2454
 Gly Ser Pro Val Lys Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr Ala
                 795                 800                 805

 ccg gcc gtg cag cgg gtc gtg tgg aac tca tca act gtc cag cag aag     2502
 Pro Ala Val Gln Arg Val Val Trp Asn Ser Ser Thr Val Gln Gln Lys
             810                 815                 820

 gag atc aca cag agc cca tcc acg tcc acc atc acc ctg gtg acc agc     2550
 Glu Ile Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu Val Thr Ser
         825                 830                 835

 aca cag tca tcg ccc ctg gtc acc agc tcg ggg tcc atg agc acc ctt     2598
 Thr Gln Ser Ser Pro Leu Val Thr Ser Ser Gly Ser Met Ser Thr Leu
     840                 845                 850

 gtg tcc tca gtc aac gct gac ctg ccc atc gcc act gcc tca gct gat     2646
 Val Ser Ser Val Asn Ala Asp Leu Pro Ile Ala Thr Ala Ser Ala Asp
 855                 860                 865                 870

 gtc gcc gct gat att gcc aag tac act agc aaa atg atg gat gca ata     2694
 Val Ala Ala Asp Ile Ala Lys Tyr Thr Ser Lys Met Met Asp Ala Ile
                 875                 880                 885

 aaa gga aca atg aca gaa ata tac aac gat ctt tct aaa aac act act     2742
 Lys Gly Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys Asn Thr Thr
             890                 895                 900

 gga agc aca ata gct gag att cgc agg ctg agg atc gag ata gag aag     2790
 Gly Ser Thr Ile Ala Glu Ile Arg Arg Leu Arg Ile Glu Ile Glu Lys
         905                 910                 915

 ctc cag tgg ctg cac cag caa gag ctc tcc gaa atg aaa cac aac tta     2838
 Leu Gln Trp Leu His Gln Gln Glu Leu Ser Glu Met Lys His Asn Leu
     920                 925                 930

 gag ctg acc atg gcg gag atg cgg cag agc ctg gag cag gag cgg gac     2886
 Glu Leu Thr Met Ala Glu Met Arg Gln Ser Leu Glu Gln Glu Arg Asp
 935                 940                 945                 950

 cgg ctc atc gcc gag gtg aag aag cag ctg gag ttg gag aag cag cag     2934
 Arg Leu Ile Ala Glu Val Lys Lys Gln Leu Glu Leu Glu Lys Gln Gln
                 955                 960                 965

 gcg gtg gat gag acc aag aag aag cag tgg tgc gcc aac tgc aag aag     2982
 Ala Val Asp Glu Thr Lys Lys Lys Gln Trp Cys Ala Asn Cys Lys Lys
             970                 975                 980

 gag gcc atc ttt tac tgc tgt tgg aac acc agc tac tgt gac tac ccc     3030
 Glu Ala Ile Phe Tyr Cys Cys Trp Asn Thr Ser Tyr Cys Asp Tyr Pro
         985                 990                 995

 tgc cag caa gcc cac tgg cct gag cac atg aag tcc tgc acc cag tca     3078
 Cys Gln Gln Ala His Trp Pro Glu His Met Lys Ser Cys Thr Gln Ser
    1000                1005                1010

 gct act gct cct cag cag gaa gcg gat gct gag gtg aac aca gaa aca     3126
 Ala Thr Ala Pro Gln Gln Glu Ala Asp Ala Glu Val Asn Thr Glu Thr
1015                1020                1025                1030

 cta aat aag tcc tcc cag ggg agc tcc tcg agc aca caa tca gca cct     3174
 Leu Asn Lys Ser Ser Gln Gly Ser Ser Ser Ser Thr Gln Ser Ala Pro
                1035                1040                1045

 tca gaa acg gcc agc gcc tcc aaa gag aag gag acg tca gct gag aaa     3222
 Ser Glu Thr Ala Ser Ala Ser Lys Glu Lys Glu Thr Ser Ala Glu Lys
            1050                1055                1060

 agc aag gag agt ggc tcg acc ctt gac ctt tct ggc tcc aga gag acg     3270
 Ser Lys Glu Ser Gly Ser Thr Leu Asp Leu Ser Gly Ser Arg Glu Thr
        1065                1070                1075

 ccc tcc tcc att ctc tta ggc tcc aac caa ggc tct gac cat tcc cgg     3318
 Pro Ser Ser Ile Leu Leu Gly Ser Asn Gln Gly Ser Asp His Ser Arg
    1080                1085                1090

 agt aat aaa tcc agt tgg agc agc agt gat gag aag agg gga tcg aca     3366
 Ser Asn Lys Ser Ser Trp Ser Ser Ser Asp Glu Lys Arg Gly Ser Thr
1095                1100                1105                1110

 cgt tcc gat cac aac acc agt acc agc acg aag agc ctc ctc ccg aaa     3414
 Arg Ser Asp His Asn Thr Ser Thr Ser Thr Lys Ser Leu Leu Pro Lys
                1115                1120                1125

 gag tct cgg ctg gac acc ttc tgg gac tag c agtgaatcgg gacacaaacc     3465
 Glu Ser Arg Leu Asp Thr Phe Trp Asp 
            1130                1135

 acccacccca ttgggagaaa aacccagacg ccaggaaaag aagaaacaac aaaggcagga   3525

 gaacagccac tttcagactt gaaaatgaca aaaccctcag ttgagcctga gcccccggcg   3585

 cgggggctgc tacactacag gacacccagc atcggctttg actgcagact gttcacccac   3645

 acgagccctg tgcttttggt gtaaataatg tacaatttgt ggatgtcatt gaatctagag   3705

 gactttcccc tttttatatt tgtattaact ttaacttatt aaaaaaaaaa a            3756




      <210> 260
      <211> 3767
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (37)..(2256)

      <400> 260
 atgttttata agtattgaca ttacacagtg ttaaca  atg cat cca cag agc ttg      54
                                          Met His Pro Gln Ser Leu
                                            1               5

 gct gaa gag gaa ata aaa aca gaa cag gag gtg gta gag ggc atg gat      102
 Ala Glu Glu Glu Ile Lys Thr Glu Gln Glu Val Val Glu Gly Met Asp
              10                  15                  20

 atc tct act cgc tcc aaa gat cct ggc tct gca gag aga aca gcc cag      150
 Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser Ala Glu Arg Thr Ala Gln
          25                  30                  35

 aaa aga aag ttc ccc agc cct cca cat tct tcc aat ggc cac tcg ccg      198
 Lys Arg Lys Phe Pro Ser Pro Pro His Ser Ser Asn Gly His Ser Pro
      40                  45                  50

 cag gac aca tca aca agc ccc att aaa aag aaa aag aaa cct ggc tta      246
 Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys Lys Lys Lys Pro Gly Leu
  55                  60                  65                  70

 ctg aac agt aac aat aag gag cag gat gga cgg aat gat ttc tac tgc      294
 Leu Asn Ser Asn Asn Lys Glu Gln Asp Gly Arg Asn Asp Phe Tyr Cys
                  75                  80                  85

 tgg gtt tgt cac cgg gaa ggc caa gtc ctt tgc tgt gag ctc tgt ccc      342
 Trp Val Cys His Arg Glu Gly Gln Val Leu Cys Cys Glu Leu Cys Pro
              90                  95                 100

 cgg gtt tat cac gct aag tgt ctg aga ctg aca tcg gaa cca gag ggg      390
 Arg Val Tyr His Ala Lys Cys Leu Arg Leu Thr Ser Glu Pro Glu Gly
         105                 110                 115

 gac tgg ttt tgt cct gaa tgt gag aaa att aca gta gca gaa tgc atc      438
 Asp Trp Phe Cys Pro Glu Cys Glu Lys Ile Thr Val Ala Glu Cys Ile
     120                 125                 130

 gag acc cag agt aaa gcc atg aca atg ctc acc att gaa cag tta tcc      486
 Glu Thr Gln Ser Lys Ala Met Thr Met Leu Thr Ile Glu Gln Leu Ser
 135                 140                 145                 150

 tac ctg ctc aag ttt gcc att cag aaa atg aaa cag cca ggg aca gat      534
 Tyr Leu Leu Lys Phe Ala Ile Gln Lys Met Lys Gln Pro Gly Thr Asp
                 155                 160                 165

 gca ttc cag aag ccc gtt cca ttg gaa cag cac cct gac tat gcg gaa      582
 Ala Phe Gln Lys Pro Val Pro Leu Glu Gln His Pro Asp Tyr Ala Glu
             170                 175                 180

 tac atc ttc cat cca atg gac ctt tgt aca ttg gaa aag aat gcg aaa      630
 Tyr Ile Phe His Pro Met Asp Leu Cys Thr Leu Glu Lys Asn Ala Lys
         185                 190                 195

 aag aaa atg tat ggc tgc aca gaa gcc ttc ctg gct gat gca aag tgg      678
 Lys Lys Met Tyr Gly Cys Thr Glu Ala Phe Leu Ala Asp Ala Lys Trp
     200                 205                 210

 att ttg cac aac tgc atc att tat aat ggg gga aat cac aaa ttg acg      726
 Ile Leu His Asn Cys Ile Ile Tyr Asn Gly Gly Asn His Lys Leu Thr
 215                 220                 225                 230

 caa ata gcg aaa gta gtc atc aaa atc tgt gaa cat gag atg aat gaa      774
 Gln Ile Ala Lys Val Val Ile Lys Ile Cys Glu His Glu Met Asn Glu
                 235                 240                 245

 atc gaa gta tgt cca gaa tgt tat cta gct gct tgc caa aaa cga gat      822
 Ile Glu Val Cys Pro Glu Cys Tyr Leu Ala Ala Cys Gln Lys Arg Asp
             250                 255                 260

 aac tgg ttt tgt gag cct tgt agc aat cca cat cct ttg gtc tgg gcc      870
 Asn Trp Phe Cys Glu Pro Cys Ser Asn Pro His Pro Leu Val Trp Ala
         265                 270                 275

 aaa ctg aag ggg ttt cca ttc tgg cct gca aaa gct cta agg gat aaa      918
 Lys Leu Lys Gly Phe Pro Phe Trp Pro Ala Lys Ala Leu Arg Asp Lys
     280                 285                 290

 gac ggg cag gtc gat gcc cga ttc ttt gga caa cat gac agg gcc tgg      966
 Asp Gly Gln Val Asp Ala Arg Phe Phe Gly Gln His Asp Arg Ala Trp
 295                 300                 305                 310

 gtt cca ata aat aat tgc tac ctc atg tct aaa gaa att cct ttt tct     1014
 Val Pro Ile Asn Asn Cys Tyr Leu Met Ser Lys Glu Ile Pro Phe Ser
                 315                 320                 325

 gtg aaa aag act aag agc atc ttc aac agt gcc atg caa gag atg gag     1062
 Val Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu
             330                 335                 340

 gtt tac gtg gag aac atc cgc agg aag ttt ggg gtt ttt aat tac tct     1110
 Val Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser
         345                 350                 355

 cca ttt agg aca ccc tac aca ccc aac agc cag tat caa atg ctg ctc     1158
 Pro Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu
     360                 365                 370

 gat ccc acc aac ccc agc gcc ggc act gcc aag ata gac aag cag gag     1206
 Asp Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu
 375                 380                 385                 390

 aag gtc aag ctc aac ttt gac atg acg gca tcc ccc aag atc ctg atg     1254
 Lys Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met
                 395                 400                 405

 agc aag cct gtg ctg agt ggg ggc aca ggc cgc cgg att tcc ttg tcg     1302
 Ser Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser
             410                 415                 420

 gat atg ccg cgc tcc ccc atg agc aca aac tct tct gtg cac acg ggc     1350
 Asp Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly
         425                 430                 435

 tcc gac gtg gag cag gat gct gag aag aag gcc acg tcg agc cac ttc     1398
 Ser Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe
     440                 445                 450

 agt gcg agc gag gag tcc atg gac ttc ctg gat aag agc aca gct tca     1446
 Ser Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser
 455                 460                 465                 470

 cca gcc tcc acc aag acg gga caa gca ggg agt tta tcc ggc agc cca     1494
 Pro Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro
                 475                 480                 485

 aag ccc ttc tct cct caa ctg tca gct cct atc acg acg aaa acg gac     1542
 Lys Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp
             490                 495                 500

 aaa acc tcc acc acc ggc agc atc ctg aat ctt aac ctg gat cga agc     1590
 Lys Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser
         505                 510                 515

 aaa gct gag atg gat ttg aag gag ctg agc gag tcg gtc cag caa cag     1638
 Lys Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln
     520                 525                 530

 tcc acc cct gtt cct ctc atc tct ccc aag cgc cag att cgt agc agg     1686
 Ser Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg
 535                 540                 545                 550

 ttc cag ctg aat ctt gac aag acc ata gag agt tgc aaa gca caa tta     1734
 Phe Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu
                 555                 560                 565

 ggc ata aat gaa atc tcg gaa gat gtc tat acg gcc gta gag cac agc     1782
 Gly Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser
             570                 575                 580

 gat tcg gag gat tct gag aag tca gat agt agc gat agt gag tat atc     1830
 Asp Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile
         585                 590                 595

 agt gat gat gag cag aag tct aag aac gag cca gaa gac aca gag gac     1878
 Ser Asp Asp Glu Gln Lys Ser Lys Asn Glu Pro Glu Asp Thr Glu Asp
     600                 605                 610

 aaa gaa ggt tgt cag atg gac aaa gag cca tct gct gtt aaa aaa aag     1926
 Lys Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val Lys Lys Lys
 615                 620                 625                 630

 ccc aag cct aca aac cca gtg gag att aaa gag gag ctg aaa agc acg     1974
 Pro Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu Lys Ser Thr
                 635                 640                 645

 tca cca gcc agc gag aag gca gac cct gga gca gtc aag gac aag gcc     2022
 Ser Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys Asp Lys Ala
             650                 655                 660

 agc cct gag cct gag aag gac ttt tcc gaa aag gca aaa cct tca cct     2070
 Ser Pro Glu Pro Glu Lys Asp Phe Ser Glu Lys Ala Lys Pro Ser Pro
         665                 670                 675

 cac ccc ata aag gat aaa ctg aag gga aaa gat gag acg gat tcc cca     2118
 His Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser Pro
     680                 685                 690

 aca gtc cat ttg ggc ctg gac tct gat tca gag agc gaa ctt gtc ata     2166
 Thr Val His Leu Gly Leu Asp Ser Asp Ser Glu Ser Glu Leu Val Ile
 695                 700                 705                 710

 gat tta gga gaa gac cat tct ggg cgg gag ggt cga aaa aat aag aag     2214
 Asp Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys Asn Lys Lys
                 715                 720                 725

 gaa ccc aaa gaa cca tct ccc aaa cag gat ggc att ggc tag ttgtagg     2263
 Glu Pro Lys Glu Pro Ser Pro Lys Gln Asp Gly Ile Gly 
             730                 735

 taaaactcca ccatccacga cggtgggcag ccattctccc ccggaaacac cggtgctcac   2323

 ccgctcttcc gcccaaactt ccgcggctgg cgccacagcc accaccagca cgtcctccac   2383

 ggtcaccgtc acggccccgg cccccgccgc cacaggaagc ccagtgaaaa agcagaggcc   2443

 gcttttaccg aaggagactg ccccggccgt gcagcgggtc gtgtggaact catcaactgt   2503

 ccagcagaag gagatcacac agagcccatc cacgtccacc atcaccctgg tgaccagcac   2563

 acagtcatcg cccctggtca ccagctcggg gtccatgagc acccttgtgt cctcagtcaa   2623

 cgctgacctg cccatcgcca ctgcctcagc tgatgtcgcc gctgatattg ccaagtacac   2683

 tagcaaaatg atggatgcaa taaaaggaac aatgacagaa atatacaacg atctttctaa   2743

 aaacactact ggaagcacaa tagctgagat tcgcaggctg aggatcgaga tagagaagct   2803

 ccagtggctg caccagcaag agctctccga aatgaaacac aacttagagc tgaccatggc   2863

 ggagatgcgg cagagcctgg agcaggagcg ggaccggctc atcgccgagg tgaagaagca   2923

 gctggagttg gagaagcagc aggcggtgga tgagaccaag aagaagcagt ggtgcgccaa   2983

 ctgcaagaag gaggccatct tttactgctg ttggaacacc agctactgtg actacccctg   3043

 ccagcaagcc cactggcctg agcacatgaa gtcctgcacc cagtcagcta ctgctcctca   3103

 gcaggaagcg gatgctgagg tgaacacaga aacactaaat aagtcctccc aggggagctc   3163

 ctcgagcaca caatcagcac cttcagaaac ggccagcgcc tccaaagaga aggagacgtc   3223

 agctgagaaa agcaaggaga gtggctcgac ccttgacctt tctggctcca gagagacgcc   3283

 ctcctccatt ctcttaggct ccaaccaagg ctctgaccat tcccggagta ataaatccag   3343

 ttggagcagc agtgatgaga agaggggatc gacacgttcc gatcacaaca ccagtaccag   3403

 cacgaagagc ctcctcccga aagagtctcg gctggacacc ttctgggact agcagtgaat   3463

 cgggacacaa accacccacc ccattgggag aaaaacccag acgccaggaa aagaagaaac   3523

 aacaaaggca ggagaacagc cactttcaga cttgaaaatg acaaaaccct cagttgagcc   3583

 tgagcccccg gcgcgggggc tgctacacta caggacaccc agcatcggct ttgactgcag   3643

 actgttcacc cacacgagcc ctgtgctttt ggtgtaaata atgtacaatt tgtggatgtc   3703

 attgaatcta gaggactttc ccctttttat atttgtatta actttaactt attaaaaaaa   3763

 aaaa                                                                3767




      <210> 261
      <211> 3914
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (37)..(3582)

      <400> 261
 atgttttata agtattgaca ttacacagtg ttaaca  atg cat cca cag agc ttg      54
                                          Met His Pro Gln Ser Leu
                                            1               5

 gct gaa gag gaa ata aaa aca gaa cag gag gtg gta gag ggc atg gat      102
 Ala Glu Glu Glu Ile Lys Thr Glu Gln Glu Val Val Glu Gly Met Asp
              10                  15                  20

 atc tct act cgc tcc aaa gat cct ggc tct gca gag aga aca gcc cag      150
 Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser Ala Glu Arg Thr Ala Gln
          25                  30                  35

 aaa aga aag ttc ccc agc cct cca cat tct tcc aat ggc cac tcg ccg      198
 Lys Arg Lys Phe Pro Ser Pro Pro His Ser Ser Asn Gly His Ser Pro
      40                  45                  50

 cag gac aca tca aca agc ccc att aaa aag aaa aag aaa cct ggc tta      246
 Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys Lys Lys Lys Pro Gly Leu
  55                  60                  65                  70

 ctg aac agt aac aat aag gag cag gat gga cgg aat gat ttc tac tgc      294
 Leu Asn Ser Asn Asn Lys Glu Gln Asp Gly Arg Asn Asp Phe Tyr Cys
                  75                  80                  85

 tgg gtt tgt cac cgg gaa ggc caa gtc ctt tgc tgt gag ctc tgt ccc      342
 Trp Val Cys His Arg Glu Gly Gln Val Leu Cys Cys Glu Leu Cys Pro
              90                  95                 100

 cgg gtt tat cac gct aag tgt ctg aga ctg aca tcg gaa cca gag ggg      390
 Arg Val Tyr His Ala Lys Cys Leu Arg Leu Thr Ser Glu Pro Glu Gly
         105                 110                 115

 gac tgg ttt tgt cct gaa tgt gag aaa att aca gta gca gaa tgc atc      438
 Asp Trp Phe Cys Pro Glu Cys Glu Lys Ile Thr Val Ala Glu Cys Ile
     120                 125                 130

 gag acc cag agt aaa gcc atg aca atg ctc acc att gaa cag tta tcc      486
 Glu Thr Gln Ser Lys Ala Met Thr Met Leu Thr Ile Glu Gln Leu Ser
 135                 140                 145                 150

 tac ctg ctc aag ttt gcc att cag aaa atg aaa cag cca ggg aca gat      534
 Tyr Leu Leu Lys Phe Ala Ile Gln Lys Met Lys Gln Pro Gly Thr Asp
                 155                 160                 165

 gca ttc cag aag ccc gtt cca ttg gaa cag cac cct gac tat gcg gaa      582
 Ala Phe Gln Lys Pro Val Pro Leu Glu Gln His Pro Asp Tyr Ala Glu
             170                 175                 180

 tac atc ttc cat cca atg gac ctt tgt aca ttg gaa aag aat gcg aaa      630
 Tyr Ile Phe His Pro Met Asp Leu Cys Thr Leu Glu Lys Asn Ala Lys
         185                 190                 195

 aag aaa atg tat ggc tgc aca gaa gcc ttc ctg gct gat gca aag tgg      678
 Lys Lys Met Tyr Gly Cys Thr Glu Ala Phe Leu Ala Asp Ala Lys Trp
     200                 205                 210

 att ttg cac aac tgc atc att tat aat ggg gga aat cac aaa ttg acg      726
 Ile Leu His Asn Cys Ile Ile Tyr Asn Gly Gly Asn His Lys Leu Thr
 215                 220                 225                 230

 caa ata gcg aaa gta gtc atc aaa atc tgt gaa cat gag atg aat gaa      774
 Gln Ile Ala Lys Val Val Ile Lys Ile Cys Glu His Glu Met Asn Glu
                 235                 240                 245

 atc gaa gta tgt cca gaa tgt tat cta gct gct tgc caa aaa cga gat      822
 Ile Glu Val Cys Pro Glu Cys Tyr Leu Ala Ala Cys Gln Lys Arg Asp
             250                 255                 260

 aac tgg ttt tgt gag cct tgt agc aat cca cat cct ttg gtc tgg gcc      870
 Asn Trp Phe Cys Glu Pro Cys Ser Asn Pro His Pro Leu Val Trp Ala
         265                 270                 275

 aaa ctg aag ggg ttt cca ttc tgg cct gca aaa gct cta agg gat aaa      918
 Lys Leu Lys Gly Phe Pro Phe Trp Pro Ala Lys Ala Leu Arg Asp Lys
     280                 285                 290

 gac ggg cag gtc gat gcc cga ttc ttt gga caa cat gac agg gcc tgg      966
 Asp Gly Gln Val Asp Ala Arg Phe Phe Gly Gln His Asp Arg Ala Trp
 295                 300                 305                 310

 gtt cca ata aat aat tgc tac ctc atg tct aaa gaa att cct ttt tct     1014
 Val Pro Ile Asn Asn Cys Tyr Leu Met Ser Lys Glu Ile Pro Phe Ser
                 315                 320                 325

 gtg aaa aag act aag agc atc ttc aac agt gcc atg caa gag atg gag     1062
 Val Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu
             330                 335                 340

 gtt tac gtg gag aac atc cgc agg aag ttt ggg gtt ttt aat tac tct     1110
 Val Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser
         345                 350                 355

 cca ttt agg aca ccc tac aca ccc aac agc cag tat caa atg ctg ctc     1158
 Pro Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu
     360                 365                 370

 gat ccc acc aac ccc agc gcc ggc act gcc aag ata gac aag cag gag     1206
 Asp Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu
 375                 380                 385                 390

 aag gtc aag ctc aac ttt gac atg acg gca tcc ccc aag atc ctg atg     1254
 Lys Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met
                 395                 400                 405

 agc aag cct gtg ctg agt ggg ggc aca ggc cgc cgg att tcc ttg tcg     1302
 Ser Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser
             410                 415                 420

 gat atg ccg cgc tcc ccc atg agc aca aac tct tct gtg cac acg ggc     1350
 Asp Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly
         425                 430                 435

 tcc gac gtg gag cag gat gct gag aag aag gcc acg tcg agc cac ttc     1398
 Ser Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe
     440                 445                 450

 agt gcg agc gag gag tcc atg gac ttc ctg gat aag agc aca gct tca     1446
 Ser Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser
 455                 460                 465                 470

 cca gcc tcc acc aag acg gga caa gca ggg agt tta tcc ggc agc cca     1494
 Pro Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro
                 475                 480                 485

 aag ccc ttc tct cct caa ctg tca gct cct atc acg acg aaa acg gac     1542
 Lys Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp
             490                 495                 500

 aaa acc tcc acc acc ggc agc atc ctg aat ctt aac ctg gat cga agc     1590
 Lys Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser
         505                 510                 515

 aaa gct gag atg gat ttg aag gag ctg agc gag tcg gtc cag caa cag     1638
 Lys Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln
     520                 525                 530

 tcc acc cct gtt cct ctc atc tct ccc aag cgc cag att cgt agc agg     1686
 Ser Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg
 535                 540                 545                 550

 ttc cag ctg aat ctt gac aag acc ata gag agt tgc aaa gca caa tta     1734
 Phe Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu
                 555                 560                 565

 ggc ata aat gaa atc tcg gaa gat gtc tat acg gcc gta gag cac agc     1782
 Gly Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser
             570                 575                 580

 gat tcg gag gat tct gag aag tca gat agt agc gat agt gag tat atc     1830
 Asp Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile
         585                 590                 595

 agt gat gat gag cag aag tct aag aac gag cca gaa gac aca gag gac     1878
 Ser Asp Asp Glu Gln Lys Ser Lys Asn Glu Pro Glu Asp Thr Glu Asp
     600                 605                 610

 aaa gaa ggt tgt cag atg gac aaa gag cca tct gct gtt aaa aaa aag     1926
 Lys Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val Lys Lys Lys
 615                 620                 625                 630

 ccc aag cct aca aac cca gtg gag att aaa gag gag ctg aaa agc acg     1974
 Pro Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu Lys Ser Thr
                 635                 640                 645

 tca cca gcc agc gag aag gca gac cct gga gca gtc aag gac aag gcc     2022
 Ser Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys Asp Lys Ala
             650                 655                 660

 agc cct gag cct gag aag gac ttt tcc gaa aag gca aaa cct tca cct     2070
 Ser Pro Glu Pro Glu Lys Asp Phe Ser Glu Lys Ala Lys Pro Ser Pro
         665                 670                 675

 cac ccc ata aag gat aaa ctg aag gga aaa gat gag acg gat tcc cca     2118
 His Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser Pro
     680                 685                 690

 aca gtc cat ttg ggc ctg gac tct gat tca gag agc gaa ctt gtc ata     2166
 Thr Val His Leu Gly Leu Asp Ser Asp Ser Glu Ser Glu Leu Val Ile
 695                 700                 705                 710

 gat tta gga gaa gac cat tct ggg cgg gag ggt cga aaa aat aag aag     2214
 Asp Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys Asn Lys Lys
                 715                 720                 725

 gaa ccc aaa gaa cca tct ccc aaa cag gat gtt gta ggt aaa act cca     2262
 Glu Pro Lys Glu Pro Ser Pro Lys Gln Asp Val Val Gly Lys Thr Pro
             730                 735                 740

 cca tcc acg acg gtg ggc agc cat tct ccc ccg gaa aca ccg gtg ctc     2310
 Pro Ser Thr Thr Val Gly Ser His Ser Pro Pro Glu Thr Pro Val Leu
         745                 750                 755

 acc cgc tct tcc gcc caa act tcc gcg gct ggc gcc aca gcc acc acc     2358
 Thr Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr Thr
     760                 765                 770

 agc acg tcc tcc acg gtc acc gtc acg gcc ccg gcc ccc gcc gcc aca     2406
 Ser Thr Ser Ser Thr Val Thr Val Thr Ala Pro Ala Pro Ala Ala Thr
 775                 780                 785                 790

 gga agc cca gtg aaa aag cag agg ccg ctt tta ccg aag gag act gcc     2454
 Gly Ser Pro Val Lys Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr Ala
                 795                 800                 805

 ccg gcc gtg cag cgg gtc gtg tgg aac tca tca agt aag ttt caa acg     2502
 Pro Ala Val Gln Arg Val Val Trp Asn Ser Ser Ser Lys Phe Gln Thr
             810                 815                 820

 tcc tcc caa aag tgg cac atg cag aag atg cag cgt cag cag cag cag     2550
 Ser Ser Gln Lys Trp His Met Gln Lys Met Gln Arg Gln Gln Gln Gln
         825                 830                 835

 cag cag cag caa aac cag cag cag cag cct cag tct tcc cag ggg acg     2598
 Gln Gln Gln Gln Asn Gln Gln Gln Gln Pro Gln Ser Ser Gln Gly Thr
     840                 845                 850

 aga tat cag acc aga cag gct gtg aaa gct gtc cag cag aag gag atc     2646
 Arg Tyr Gln Thr Arg Gln Ala Val Lys Ala Val Gln Gln Lys Glu Ile
 855                 860                 865                 870

 aca cag agc cca tcc acg tcc acc atc acc ctg gtg acc agc aca cag     2694
 Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu Val Thr Ser Thr Gln
                 875                 880                 885

 tca tcg ccc ctg gtc acc agc tcg ggg tcc atg agc acc ctt gtg tcc     2742
 Ser Ser Pro Leu Val Thr Ser Ser Gly Ser Met Ser Thr Leu Val Ser
             890                 895                 900

 tca gtc aac gct gac ctg ccc atc gcc act gcc tca gct gat gtc gcc     2790
 Ser Val Asn Ala Asp Leu Pro Ile Ala Thr Ala Ser Ala Asp Val Ala
         905                 910                 915

 gct gat att gcc aag tac act agc aaa atg atg gat gca ata aaa gga     2838
 Ala Asp Ile Ala Lys Tyr Thr Ser Lys Met Met Asp Ala Ile Lys Gly
     920                 925                 930

 aca atg aca gaa ata tac aac gat ctt tct aaa aac act act gga agc     2886
 Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys Asn Thr Thr Gly Ser
 935                 940                 945                 950

 aca ata gct gag att cgc agg ctg agg atc gag ata gag aag ctc cag     2934
 Thr Ile Ala Glu Ile Arg Arg Leu Arg Ile Glu Ile Glu Lys Leu Gln
                 955                 960                 965

 tgg ctg cac cag caa gag ctc tcc gaa atg aaa cac aac tta gag ctg     2982
 Trp Leu His Gln Gln Glu Leu Ser Glu Met Lys His Asn Leu Glu Leu
             970                 975                 980

 acc atg gcg gag atg cgg cag agc ctg gag cag gag cgg gac cgg ctc     3030
 Thr Met Ala Glu Met Arg Gln Ser Leu Glu Gln Glu Arg Asp Arg Leu
         985                 990                 995

 atc gcc gag gtg aag aag cag ctg gag ttg gag aag cag cag gcg gtg     3078
 Ile Ala Glu Val Lys Lys Gln Leu Glu Leu Glu Lys Gln Gln Ala Val
    1000                1005                1010

 gat gag acc aag aag aag cag tgg tgc gcc aac tgc aag aag gag gcc     3126
 Asp Glu Thr Lys Lys Lys Gln Trp Cys Ala Asn Cys Lys Lys Glu Ala
1015                1020                1025                1030

 atc ttt tac tgc tgt tgg aac acc agc tac tgt gac tac ccc tgc cag     3174
 Ile Phe Tyr Cys Cys Trp Asn Thr Ser Tyr Cys Asp Tyr Pro Cys Gln
                1035                1040                1045

 caa gcc cac tgg cct gag cac atg aag tcc tgc acc cag tca gct act     3222
 Gln Ala His Trp Pro Glu His Met Lys Ser Cys Thr Gln Ser Ala Thr
            1050                1055                1060

 gct cct cag cag gaa gcg gat gct gag gtg aac aca gaa aca cta aat     3270
 Ala Pro Gln Gln Glu Ala Asp Ala Glu Val Asn Thr Glu Thr Leu Asn
        1065                1070                1075

 aag tcc tcc cag ggg agc tcc tcg agc aca caa tca gca cct tca gaa     3318
 Lys Ser Ser Gln Gly Ser Ser Ser Ser Thr Gln Ser Ala Pro Ser Glu
    1080                1085                1090

 acg gcc agc gcc tcc aaa gag aag gag acg tca gct gag aaa agc aag     3366
 Thr Ala Ser Ala Ser Lys Glu Lys Glu Thr Ser Ala Glu Lys Ser Lys
1095                1100                1105                1110

 gag agt ggc tcg acc ctt gac ctt tct ggc tcc aga gag acg ccc tcc     3414
 Glu Ser Gly Ser Thr Leu Asp Leu Ser Gly Ser Arg Glu Thr Pro Ser
                1115                1120                1125

 tcc att ctc tta ggc tcc aac caa ggc tct gac cat tcc cgg agt aat     3462
 Ser Ile Leu Leu Gly Ser Asn Gln Gly Ser Asp His Ser Arg Ser Asn
            1130                1135                1140

 aaa tcc agt tgg agc agc agt gat gag aag agg gga tcg aca cgt tcc     3510
 Lys Ser Ser Trp Ser Ser Ser Asp Glu Lys Arg Gly Ser Thr Arg Ser
        1145                1150                1155

 gat cac aac acc agt acc agc acg aag agc ctc ctc ccg aaa gag tct     3558
 Asp His Asn Thr Ser Thr Ser Thr Lys Ser Leu Leu Pro Lys Glu Ser
    1160                1165                1170

 cgg ctg gac acc ttc tgg gac tag cagtgaatcg ggacacaaac cacccacccc    3612
 Arg Leu Asp Thr Phe Trp Asp 
1175                1180

 attgggagaa aaacccagac gccaggaaaa gaagaaacaa caaaggcagg agaacagcca   3672

 ctttcagact tgaaaatgac aaaaccctca gttgagcctg agcccccggc gcgggggctg   3732

 ctacactaca ggacacccag catcggcttt gactgcagac tgttcaccca cacgagccct   3792

 gtgcttttgg tgtaaataat gtacaatttg tggatgtcat tgaatctaga ggactttccc   3852

 ctttttatat ttgtattaac tttaacttat taaaaaaaaa aaaagaaaaa gaaaaacgat   3912

 tt                                                                  3914




      <210> 262
      <211> 4128
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (255)..(3815)

      <400> 262
 ggagtgtaga ggaaataaaa tcatgtctgt ggctcatgac agcattccat attcagttgt     60

 tgggttgtgt tgttgttgtt gtgtgtgttt ttaataatac catgtaactg tttaaaaaaa    120

 tttccttttt gatcaagtcc caaatctgcc agcctgttct ctcttcctaa ctgtggaaaa    180

 atgagacggt tgcttgaaca tttgttggct tggctgaaga ggaaataaaa acagaacagg    240

 aggtggtaga gggc  atg gat atc tct act cgc tcc aaa gat cct ggc tct     290
                  Met Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser
                    1               5                  10

 gca gag aga aca gcc cag aaa aga aag ttc ccc agc cct cca cat tct      338
 Ala Glu Arg Thr Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser
          15                  20                  25

 tcc aat ggc cac tcg ccg cag gac aca tca aca agc ccc att aaa aag      386
 Ser Asn Gly His Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys
      30                  35                  40

 aaa aag aaa cct ggc tta ctg aac agt aac aat aag gag cag tca gaa      434
 Lys Lys Lys Pro Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Ser Glu
  45                  50                  55                  60

 cta aga cat ggt ccg ttt tac tat atg aag cag cca ctc acc aca gac      482
 Leu Arg His Gly Pro Phe Tyr Tyr Met Lys Gln Pro Leu Thr Thr Asp
                  65                  70                  75

 cct gtt gat gtt gta ccg cag gat gga cgg aat gat ttc tac tgc tgg      530
 Pro Val Asp Val Val Pro Gln Asp Gly Arg Asn Asp Phe Tyr Cys Trp
              80                  85                  90

 gtt tgt cac cgg gaa ggc caa gtc ctt tgc tgt gag ctc tgt ccc cgg      578
 Val Cys His Arg Glu Gly Gln Val Leu Cys Cys Glu Leu Cys Pro Arg
          95                 100                 105

 gtt tat cac gct aag tgt ctg aga ctg aca tcg gaa cca gag ggg gac      626
 Val Tyr His Ala Lys Cys Leu Arg Leu Thr Ser Glu Pro Glu Gly Asp
     110                 115                 120

 tgg ttt tgt cct gaa tgt gag aaa att aca gta gca gaa tgc atc gag      674
 Trp Phe Cys Pro Glu Cys Glu Lys Ile Thr Val Ala Glu Cys Ile Glu
 125                 130                 135                 140

 acc cag agt aaa gcc atg aca atg ctc acc att gaa cag tta tcc tac      722
 Thr Gln Ser Lys Ala Met Thr Met Leu Thr Ile Glu Gln Leu Ser Tyr
                 145                 150                 155

 ctg ctc aag ttt gcc att cag aaa atg aaa cag cca ggg aca gat gca      770
 Leu Leu Lys Phe Ala Ile Gln Lys Met Lys Gln Pro Gly Thr Asp Ala
             160                 165                 170

 ttc cag aag ccc gtt cca ttg gaa cag cac cct gac tat gcg gaa tac      818
 Phe Gln Lys Pro Val Pro Leu Glu Gln His Pro Asp Tyr Ala Glu Tyr
         175                 180                 185

 atc ttc cat cca atg gac ctt tgt aca ttg gaa aag aat gcg aaa aag      866
 Ile Phe His Pro Met Asp Leu Cys Thr Leu Glu Lys Asn Ala Lys Lys
     190                 195                 200

 aaa atg tat ggc tgc aca gaa gcc ttc ctg gct gat gca aag tgg att      914
 Lys Met Tyr Gly Cys Thr Glu Ala Phe Leu Ala Asp Ala Lys Trp Ile
 205                 210                 215                 220

 ttg cac aac tgc atc att tat aat ggg gga aat cac aaa ttg acg caa      962
 Leu His Asn Cys Ile Ile Tyr Asn Gly Gly Asn His Lys Leu Thr Gln
                 225                 230                 235

 ata gcg aaa gta gtc atc aaa atc tgt gaa cat gag atg aat gaa atc     1010
 Ile Ala Lys Val Val Ile Lys Ile Cys Glu His Glu Met Asn Glu Ile
             240                 245                 250

 gaa gta tgt cca gaa tgt tat cta gct gct tgc caa aaa cga gat aac     1058
 Glu Val Cys Pro Glu Cys Tyr Leu Ala Ala Cys Gln Lys Arg Asp Asn
         255                 260                 265

 tgg ttt tgt gag cct tgt agc aat cca cat cct ttg gtc tgg gcc aaa     1106
 Trp Phe Cys Glu Pro Cys Ser Asn Pro His Pro Leu Val Trp Ala Lys
     270                 275                 280

 ctg aag ggg ttt cca ttc tgg cct gca aaa gct cta agg gat aaa gac     1154
 Leu Lys Gly Phe Pro Phe Trp Pro Ala Lys Ala Leu Arg Asp Lys Asp
 285                 290                 295                 300

 ggg cag gtc gat gcc cga ttc ttt gga caa cat gac agg gcc tgg gtt     1202
 Gly Gln Val Asp Ala Arg Phe Phe Gly Gln His Asp Arg Ala Trp Val
                 305                 310                 315

 cca ata aat aat tgc tac ctc atg tct aaa gaa att cct ttt tct gtg     1250
 Pro Ile Asn Asn Cys Tyr Leu Met Ser Lys Glu Ile Pro Phe Ser Val
             320                 325                 330

 aaa aag act aag agc atc ttc aac agt gcc atg caa gag atg gag gtt     1298
 Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu Val
         335                 340                 345

 tac gtg gag aac atc cgc agg aag ttt ggg gtt ttt aat tac tct cca     1346
 Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser Pro
     350                 355                 360

 ttt agg aca ccc tac aca ccc aac agc cag tat caa atg ctg ctc gat     1394
 Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu Asp
 365                 370                 375                 380

 ccc acc aac ccc agc gcc ggc act gcc aag ata gac aag cag gag aag     1442
 Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu Lys
                 385                 390                 395

 gtc aag ctc aac ttt gac atg acg gca tcc ccc aag atc ctg atg agc     1490
 Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met Ser
             400                 405                 410

 aag cct gtg ctg agt ggg ggc aca ggc cgc cgg att tcc ttg tcg gat     1538
 Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser Asp
         415                 420                 425

 atg ccg cgc tcc ccc atg agc aca aac tct tct gtg cac acg ggc tcc     1586
 Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly Ser
     430                 435                 440

 gac gtg gag cag gat gct gag aag aag gcc acg tcg agc cac ttc agt     1634
 Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe Ser
 445                 450                 455                 460

 gcg agc gag gag tcc atg gac ttc ctg gat aag agc aca gct tca cca     1682
 Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser Pro
                 465                 470                 475

 gcc tcc acc aag acg gga caa gca ggg agt tta tcc ggc agc cca aag     1730
 Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro Lys
             480                 485                 490

 ccc ttc tct cct caa ctg tca gct cct atc acg acg aaa acg gac aaa     1778
 Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp Lys
         495                 500                 505

 acc tcc acc acc ggc agc atc ctg aat ctt aac ctg gat cga agc aaa     1826
 Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser Lys
     510                 515                 520

 gct gag atg gat ttg aag gag ctg agc gag tcg gtc cag caa cag tcc     1874
 Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln Ser
 525                 530                 535                 540

 acc cct gtt cct ctc atc tct ccc aag cgc cag att cgt agc agg ttc     1922
 Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg Phe
                 545                 550                 555

 cag ctg aat ctt gac aag acc ata gag agt tgc aaa gca caa tta ggc     1970
 Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu Gly
             560                 565                 570

 ata aat gaa atc tcg gaa gat gtc tat acg gcc gta gag cac agc gat     2018
 Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser Asp
         575                 580                 585

 tcg gag gat tct gag aag tca gat agt agc gat agt gag tat atc agt     2066
 Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile Ser
     590                 595                 600

 gat gat gag cag aag tct aag aac gag cca gaa gac aca gag gac aaa     2114
 Asp Asp Glu Gln Lys Ser Lys Asn Glu Pro Glu Asp Thr Glu Asp Lys
 605                 610                 615                 620

 gaa ggt tgt cag atg gac aaa gag cca tct gct gtt aaa aaa aag ccc     2162
 Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val Lys Lys Lys Pro
                 625                 630                 635

 aag cct aca aac cca gtg gag att aaa gag gag ctg aaa agc acg tca     2210
 Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu Lys Ser Thr Ser
             640                 645                 650

 cca gcc agc gag aag gca gac cct gga gca gtc aag gac aag gcc agc     2258
 Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys Asp Lys Ala Ser
         655                 660                 665

 cct gag cct gag aag gac ttt tcc gaa aag gca aaa cct tca cct cac     2306
 Pro Glu Pro Glu Lys Asp Phe Ser Glu Lys Ala Lys Pro Ser Pro His
     670                 675                 680

 ccc ata aag gat aaa ctg aag gga aaa gat gag acg gat tcc cca aca     2354
 Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser Pro Thr
 685                 690                 695                 700

 gtc cat ttg ggc ctg gac tct gat tca gag agc gaa ctt gtc ata gat     2402
 Val His Leu Gly Leu Asp Ser Asp Ser Glu Ser Glu Leu Val Ile Asp
                 705                 710                 715

 tta gga gaa gac cat tct ggg cgg gag ggt cga aaa aat aag aag gaa     2450
 Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys Asn Lys Lys Glu
             720                 725                 730

 ccc aaa gaa cca tct ccc aaa cag gat gtt gta ggt aaa act cca cca     2498
 Pro Lys Glu Pro Ser Pro Lys Gln Asp Val Val Gly Lys Thr Pro Pro
         735                 740                 745

 tcc acg acg gtg ggc agc cat tct ccc ccg gaa aca ccg gtg ctc acc     2546
 Ser Thr Thr Val Gly Ser His Ser Pro Pro Glu Thr Pro Val Leu Thr
     750                 755                 760

 cgc tct tcc gcc caa act tcc gcg gct ggc gcc aca gcc acc acc agc     2594
 Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr Thr Ser
 765                 770                 775                 780

 acg tcc tcc acg gtc acc gtc acg gcc ccg gcc ccc gcc gcc aca gga     2642
 Thr Ser Ser Thr Val Thr Val Thr Ala Pro Ala Pro Ala Ala Thr Gly
                 785                 790                 795

 agc cca gtg aaa aag cag agg ccg ctt tta ccg aag gag act gcc ccg     2690
 Ser Pro Val Lys Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr Ala Pro
             800                 805                 810

 gcc gtg cag cgg gtc gtg tgg aac tca tca agt aag ttt caa acg tcc     2738
 Ala Val Gln Arg Val Val Trp Asn Ser Ser Ser Lys Phe Gln Thr Ser
         815                 820                 825

 tcc caa aag tgg cac atg cag aag atg cag cgt cag cag cag cag cag     2786
 Ser Gln Lys Trp His Met Gln Lys Met Gln Arg Gln Gln Gln Gln Gln
     830                 835                 840

 cag cag caa aac cag cag cag cag cct cag tct tcc cag ggg acg aga     2834
 Gln Gln Gln Asn Gln Gln Gln Gln Pro Gln Ser Ser Gln Gly Thr Arg
 845                 850                 855                 860

 tat cag acc aga cag gct gtg aaa gct gtc cag cag aag gag atc aca     2882
 Tyr Gln Thr Arg Gln Ala Val Lys Ala Val Gln Gln Lys Glu Ile Thr
                 865                 870                 875

 cag agc cca tcc acg tcc acc atc acc ctg gtg acc agc aca cag tca     2930
 Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu Val Thr Ser Thr Gln Ser
             880                 885                 890

 tcg ccc ctg gtc acc agc tcg ggg tcc atg agc acc ctt gtg tcc tca     2978
 Ser Pro Leu Val Thr Ser Ser Gly Ser Met Ser Thr Leu Val Ser Ser
         895                 900                 905

 gtc aac gct gac ctg ccc atc gcc act gcc tca gct gat gtc gcc gct     3026
 Val Asn Ala Asp Leu Pro Ile Ala Thr Ala Ser Ala Asp Val Ala Ala
     910                 915                 920

 gat att gcc aag tac act agc aaa atg atg gat gca ata aaa gga aca     3074
 Asp Ile Ala Lys Tyr Thr Ser Lys Met Met Asp Ala Ile Lys Gly Thr
 925                 930                 935                 940

 atg aca gaa ata tac aac gat ctt tct aaa aac act act gga agc aca     3122
 Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys Asn Thr Thr Gly Ser Thr
                 945                 950                 955

 ata gct gag att cgc agg ctg agg atc gag ata gag aag ctc cag tgg     3170
 Ile Ala Glu Ile Arg Arg Leu Arg Ile Glu Ile Glu Lys Leu Gln Trp
             960                 965                 970

 ctg cac cag caa gag ctc tcc gaa atg aaa cac aac tta gag ctg acc     3218
 Leu His Gln Gln Glu Leu Ser Glu Met Lys His Asn Leu Glu Leu Thr
         975                 980                 985

 atg gcg gag atg cgg cag agc ctg gag cag gag cgg gac cgg ctc atc     3266
 Met Ala Glu Met Arg Gln Ser Leu Glu Gln Glu Arg Asp Arg Leu Ile
     990                 995                1000

 gcc gag gtg aag aag cag ctg gag ttg gag aag cag cag gcg gtg gat     3314
 Ala Glu Val Lys Lys Gln Leu Glu Leu Glu Lys Gln Gln Ala Val Asp
1005                1010                1015                1020

 gag acc aag aag aag cag tgg tgc gcc aac tgc aag aag gag gcc atc     3362
 Glu Thr Lys Lys Lys Gln Trp Cys Ala Asn Cys Lys Lys Glu Ala Ile
                1025                1030                1035

 ttt tac tgc tgt tgg aac acc agc tac tgt gac tac ccc tgc cag caa     3410
 Phe Tyr Cys Cys Trp Asn Thr Ser Tyr Cys Asp Tyr Pro Cys Gln Gln
            1040                1045                1050

 gcc cac tgg cct gag cac atg aag tcc tgc acc cag tca gct act gct     3458
 Ala His Trp Pro Glu His Met Lys Ser Cys Thr Gln Ser Ala Thr Ala
        1055                1060                1065

 cct cag cag gaa gcg gat gct gag gtg aac aca gaa aca cta aat aag     3506
 Pro Gln Gln Glu Ala Asp Ala Glu Val Asn Thr Glu Thr Leu Asn Lys
    1070                1075                1080

 tcc tcc cag ggg agc tcc tcg agc aca caa tca gca cct tca gaa acg     3554
 Ser Ser Gln Gly Ser Ser Ser Ser Thr Gln Ser Ala Pro Ser Glu Thr
1085                1090                1095                1100

 gcc agc gcc tcc aaa gag aag gag acg tca gct gag aaa agc aag gag     3602
 Ala Ser Ala Ser Lys Glu Lys Glu Thr Ser Ala Glu Lys Ser Lys Glu
                1105                1110                1115

 agt ggc tcg acc ctt gac ctt tct ggc tcc aga gag acg ccc tcc tcc     3650
 Ser Gly Ser Thr Leu Asp Leu Ser Gly Ser Arg Glu Thr Pro Ser Ser
            1120                1125                1130

 att ctc tta ggc tcc aac caa ggc tct gac cat tcc cgg agt aat aaa     3698
 Ile Leu Leu Gly Ser Asn Gln Gly Ser Asp His Ser Arg Ser Asn Lys
        1135                1140                1145

 tcc agt tgg agc agc agt gat gag aag agg gga tcg aca cgt tcc gat     3746
 Ser Ser Trp Ser Ser Ser Asp Glu Lys Arg Gly Ser Thr Arg Ser Asp
    1150                1155                1160

 cac aac acc agt acc agc acg aag agc ctc ctc ccg aaa gag tct cgg     3794
 His Asn Thr Ser Thr Ser Thr Lys Ser Leu Leu Pro Lys Glu Ser Arg
1165                1170                1175                1180

 ctg gac acc ttc tgg gac tag ca gtgaatcggg acacaaacca cccaccccat     3847
 Leu Asp Thr Phe Trp Asp 
                1185

 tgggagaaaa acccagacgc caggaaaaga agaaacaaca aaggcaggag aacagccact   3907

 ttcagacttg aaaatgacaa aaccctcagt tgagcctgag cccccggcgc gggggctgct   3967

 acactacagg acacccagca tcggctttga ctgcagactg ttcacccaca cgagccctgt   4027

 gcttttggtg taaataatgt acaatttgtg gatgtcattg aatctagagg actttcccct   4087

 ttttatattt gtattaactt taacttatta aaaaaaaaaa a                       4128




      <210> 263
      <211> 1416
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1416)

      <400> 263
  atg gtg ctg gac tca ggg gct cag gcg tat gat cag gca ccc ccc agc      48
  Met Val Leu Asp Ser Gly Ala Gln Ala Tyr Asp Gln Ala Pro Pro Ser
    1               5                  10                  15

 ccg cct acc agt ccc cca tcc ctg cgc cat agg ctg aag ccc tca gac       96
 Pro Pro Thr Ser Pro Pro Ser Leu Arg His Arg Leu Lys Pro Ser Asp
              20                  25                  30

 cga gat ggg cca cca ctg tac ccc tgg tct cag tcc ctg gcc ttg ccc      144
 Arg Asp Gly Pro Pro Leu Tyr Pro Trp Ser Gln Ser Leu Ala Leu Pro
          35                  40                  45

 ctg gct ctg gca gtc ccc cca gcg ctg cag ccc cag cct gag cag cag      192
 Leu Ala Leu Ala Val Pro Pro Ala Leu Gln Pro Gln Pro Glu Gln Gln
      50                  55                  60

 ccg ttc tca cag atg ctc ctg ggc cac cgt ggc cac atg cgt cgc agt      240
 Pro Phe Ser Gln Met Leu Leu Gly His Arg Gly His Met Arg Arg Ser
  65                  70                  75                  80

 gag agc acc tac tct gta aat agt act ggc cgg cgg ggg cgt ggc acc      288
 Glu Ser Thr Tyr Ser Val Asn Ser Thr Gly Arg Arg Gly Arg Gly Thr
                  85                  90                  95

 ctg gga cgg cct cca cct gga cgg gga cgg aac cca ggt ggg ggc acc      336
 Leu Gly Arg Pro Pro Pro Gly Arg Gly Arg Asn Pro Gly Gly Gly Thr
             100                 105                 110

 ctg cgg cct gca gcc tcc ctg cct cac att gct aag act caa agg gat      384
 Leu Arg Pro Ala Ala Ser Leu Pro His Ile Ala Lys Thr Gln Arg Asp
         115                 120                 125

 gca ggc cat att gcc agc aag agc ccc tgc atg ttg gtg gcc ctg cgg      432
 Ala Gly His Ile Ala Ser Lys Ser Pro Cys Met Leu Val Ala Leu Arg
     130                 135                 140

 cca acc aac atg gac cgt gag cga gac aag ttc ttc cag tcc cat tac      480
 Pro Thr Asn Met Asp Arg Glu Arg Asp Lys Phe Phe Gln Ser His Tyr
 145                 150                 155                 160

 acc tac aat cca cag ttt gag tac cag gag ccc atg ccc acg gct gtg      528
 Thr Tyr Asn Pro Gln Phe Glu Tyr Gln Glu Pro Met Pro Thr Ala Val
                 165                 170                 175

 ctg gaa aag tac tgc gag gcc tct gga cag ttc atc cat cag gca gtt      576
 Leu Glu Lys Tyr Cys Glu Ala Ser Gly Gln Phe Ile His Gln Ala Val
             180                 185                 190

 ggc atc att gag gct gtt ctg gag aag ttt gga acc tat gaa cac ttt      624
 Gly Ile Ile Glu Ala Val Leu Glu Lys Phe Gly Thr Tyr Glu His Phe
         195                 200                 205

 gag gct gcc act ggg ggg cag ctg ctc acc aag tgc cag ata tgg tcg      672
 Glu Ala Ala Thr Gly Gly Gln Leu Leu Thr Lys Cys Gln Ile Trp Ser
     210                 215                 220

 att gtg cgc aaa tac atg cag aag gag ggc tgc gct ggg gag gtt gtg      720
 Ile Val Arg Lys Tyr Met Gln Lys Glu Gly Cys Ala Gly Glu Val Val
 225                 230                 235                 240

 gtg cag ctg agt gag gac ctg ctg tcc cag gca gtg atg atg gtg gag      768
 Val Gln Leu Ser Glu Asp Leu Leu Ser Gln Ala Val Met Met Val Glu
                 245                 250                 255

 aac agc cgg ccc aca ttg gcg atc aac ctg acc gga gcc cgc cag tac      816
 Asn Ser Arg Pro Thr Leu Ala Ile Asn Leu Thr Gly Ala Arg Gln Tyr
             260                 265                 270

 tgg ttg gag ggc atg ctg cgg cat gag ata ggc acc cac tac ctg cgg      864
 Trp Leu Glu Gly Met Leu Arg His Glu Ile Gly Thr His Tyr Leu Arg
         275                 280                 285

 ggc gtg aac aac gcg cgc cag ccg tgg cac aac gcg gag ggc cgg ctg      912
 Gly Val Asn Asn Ala Arg Gln Pro Trp His Asn Ala Glu Gly Arg Leu
     290                 295                 300

 cgg tac ggg ctg cgg ccg gcg aac ccc acg gag gag ggc ctg gcc agc      960
 Arg Tyr Gly Leu Arg Pro Ala Asn Pro Thr Glu Glu Gly Leu Ala Ser
 305                 310                 315                 320

 ctg cac agc gtg ctg ttc cgc aag cag ccg ttc ctg tgg cgc gct gca     1008
 Leu His Ser Val Leu Phe Arg Lys Gln Pro Phe Leu Trp Arg Ala Ala
                 325                 330                 335

 ctg ctc tac tac acc atc cac cgc gcc gcg cgc atg tcc ttc cgt cag     1056
 Leu Leu Tyr Tyr Thr Ile His Arg Ala Ala Arg Met Ser Phe Arg Gln
             340                 345                 350

 ctc ttc cag gac ctg gag cgc tac gtg cag gac gcc gat gtg cgc tgg     1104
 Leu Phe Gln Asp Leu Glu Arg Tyr Val Gln Asp Ala Asp Val Arg Trp
         355                 360                 365

 gag tac tgc gtg cgc gcc aag cgc ggc cag acc gac acc tcg ctg cca     1152
 Glu Tyr Cys Val Arg Ala Lys Arg Gly Gln Thr Asp Thr Ser Leu Pro
     370                 375                 380

 ggt tgt ttc agc aag gac cag gtg tac ctg aac ggc atc ctg tgc att     1200
 Gly Cys Phe Ser Lys Asp Gln Val Tyr Leu Asn Gly Ile Leu Cys Ile
 385                 390                 395                 400

 ctg gga cat cgc cag acc atc gat ttc ccg ctg ctg acc tca ctg ggc     1248
 Leu Gly His Arg Gln Thr Ile Asp Phe Pro Leu Leu Thr Ser Leu Gly
                 405                 410                 415

 aag gtg tcc tat gag gat gtg gac cac ctg cgg ccc cat ggg gtg ctg     1296
 Lys Val Ser Tyr Glu Asp Val Asp His Leu Arg Pro His Gly Val Leu
             420                 425                 430

 gat aat acc cgg atg ccc cac ctt atg cag gac ttg gca cgc tac cgg     1344
 Asp Asn Thr Arg Met Pro His Leu Met Gln Asp Leu Ala Arg Tyr Arg
         435                 440                 445

 cag cag ctg aag cac atc atg gcc acc aac cgg ctg gat gtg gcg gag     1392
 Gln Gln Leu Lys His Ile Met Ala Thr Asn Arg Leu Asp Val Ala Glu
     450                 455                 460

 ctg ggt cgc ctg ctg ccc gac tga                                     1416
 Leu Gly Arg Leu Leu Pro Asp 
 465                 470





      <210> 264
      <211> 2284
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1403)..(1588)

      <400> 264
 aatgaaagtg gaaatgtatt aattttaaat cctataaaat taatacagaa aatataatga     60

 ttgggtcatt taactatatt tttttaaata aactgaaaga taaagaacac aacacttcac    120

 acattttata tttctcttac atactctgga atcatacaca gttcttttta aagcacaaca    180

 ttaaaacctt taaaaggtat ttaagggttt ggtcaagtga atatgataaa acatacttgt    240

 ctgtataaag agaaaatgaa attgtagtca ctgttatgta ctgacattag ttacaaccta    300

 gttttaattc ttaaaacaat tttgattagc aaagctaaaa aaaaatggat gtttcagtta    360

 aatgttttaa agaggtacag atttttacaa ggacataata taagttattg ttctgtagaa    420

 atatcctatt aaatattgta tgtccctccc tctgtacact ttgtaaagaa agtaaaatac    480

 ataaaaagaa aatcatatag ggatgtgtga cattattgta attgtgtact tgagaataac    540

 gtgcaaaaat aaaaatcaga atattttcct gttattgaat gtttagtcta tttgatacca    600

 gtactaagtt aatgcttttt ctcaaggaaa aaaaatgtac agtttttgta aacctaataa    660

 acatcaaaag cagtggatta ttttcatccc cccatttctt aatttctttt tcacagcagt    720

 ggaatgcaaa gtgcttgatt gctttgaatt ttgtgactcg gatgcaaata ctggtaatat    780

 ttcagttctg tgaatttgca agtaatattt cagagaagtt aagaggtgat tggtgagtcc    840

 tttgatgagc atgtccttgg aattcatttt ttcttttatc ttcataaagg atttgtttta    900

 ttagcatctc caattcccct gagataaatt actcatgcat aaagtggttt ttgagagcac    960

 ttaaagttca tttcagtatt aatttacagc atatttaatc agtggggact gttaccacct   1020

 ccacaacaga aatcatgccc tcgagttacc ccactgcgcc cagtttagag gactagtaga   1080

 tgctaacata ctagggaatg gtcattgcca cagttaaaaa tcggcagtta agtaaatgtc   1140

 aggagtcaaa agagatagag ttgtgccatc tttgatttta tagacaagat tctgcagttc   1200

 ttccaactgt atgaacaaac gtttgcctaa tagttgaaac aataaattaa aattttaggt   1260

 aaatgacgaa gggaatgtgg tgaatgtcac tgtccagagc cataaatcag acaaaaccat   1320

 acatagcatg ctgaaaaact tttgtaatgg aacacccaac aaatgacacc taacctgtct   1380

 gtgatccaac aagtccgata ac atg ctg ctg tat ttg tat tct ctg gga atc    1432
                          Met Leu Leu Tyr Leu Tyr Ser Leu Gly Ile
                            1               5                  10

 tca gta tta ata att tca ttt ccc aca aat tct agc att cat gta agg     1480
 Ser Val Leu Ile Ile Ser Phe Pro Thr Asn Ser Ser Ile His Val Arg
                  15                  20                  25

 aaa aac atg gct aat caa tat ctt aaa ggg gca atc ttt cag agc agt     1528
 Lys Asn Met Ala Asn Gln Tyr Leu Lys Gly Ala Ile Phe Gln Ser Ser
              30                  35                  40

 ggt ttt caa agt gtg gcc gga cag cat tgg cag cat ctt aat ctc ctg     1576
 Gly Phe Gln Ser Val Ala Gly Gln His Trp Gln His Leu Asn Leu Leu
          45                  50                  55

 gga ctt tgt taa aaa tgcaaattct cagccccaac cctaatccta cctgaattgg     1631
 Gly Leu Cys 
      60

 gaaactggcg tgggacccat cagtctttgt tgtaacatgc tctccaagcg agtctgatgc   1691

 ctgatcaaac ttgcgaaaca cttttagagc acttgaggaa cctaaaagat gactggttca   1751

 gcattttgtg tggtagataa gaaagaaatt atcacaaaaa atcagaaatg aacagtgaga   1811

 gaaaaatagg accccagaca gtttatacct tccatttgct gttttaaaag tgtgagcctg   1871

 ccaagtcaac aagtatgcct ttagcgcaca tgtaaatagc ctgcacttcc taaatctcgt   1931

 gtggcctccc atggttacat tcttcaaagg taaactgagt tgagaggaag attcagcatt   1991

 taaaagagaa gggttgaaaa agattgtgtg tgtgtgtgtg tgtgtttaat tggcccaggg   2051

 ttacttaaat aaatcataac cattttgcca cattctgtaa ctgtttagct aaggtcaaat   2111

 taagtttacc ctatggattt tgtttcatct tttgtttcgt gtatatactg tttgcctttt   2171

 tcataaaaat cttggatttg ttatatattg ttcctgttat ttttgacatc tttgctattg   2231

 taaataaatt actattttgt tttaaaaaaa aaaaaaataa aaaaaaaaaa aaa          2284




      <210> 265
      <211> 1165
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(1124)

      <400> 265
 cggtcgcctt ggcgtgattt cgacttaaat cttcagcgac aggggaccgc cagccgcaca     60

 gccacttggt gctcaccacg cgcttcctct tcggactgct gagcgcggag cgg   atg     116
                                                              Met
                                                                1

 cgc gac atc gag cgc cac ttc ggc tgc atg gtt tca gag cgt gtg aag      164
 Arg Asp Ile Glu Arg His Phe Gly Cys Met Val Ser Glu Arg Val Lys
               5                  10                  15

 cag gag gcc ctg cgg tgg gtg cag gga cag gga cag ggc tgc ccc gga      212
 Gln Glu Ala Leu Arg Trp Val Gln Gly Gln Gly Gln Gly Cys Pro Gly
          20                  25                  30

 gtg gca cca gag gtg acc gag ggg gcc aaa ggg ctc gag gac acc gaa      260
 Val Ala Pro Glu Val Thr Glu Gly Ala Lys Gly Leu Glu Asp Thr Glu
      35                  40                  45

 gag cca gag gag gag gag gag gga gag gag ccc aac tac cca ctg gag      308
 Glu Pro Glu Glu Glu Glu Glu Gly Glu Glu Pro Asn Tyr Pro Leu Glu
  50                  55                  60                  65

 ttg ctg tac tgc ctg tac gag acg cag gag gac gcg ttt gtg cgc caa      356
 Leu Leu Tyr Cys Leu Tyr Glu Thr Gln Glu Asp Ala Phe Val Arg Gln
                  70                  75                  80

 gcc ctg tgc cgg ttc ccg gag ctg gcg ctg cag cga gtg cgc ttc tgc      404
 Ala Leu Cys Arg Phe Pro Glu Leu Ala Leu Gln Arg Val Arg Phe Cys
              85                  90                  95

 cgc atg gac gtg gct gtt ctg agc tac tgc gtg agg tgc tgc cct gct      452
 Arg Met Asp Val Ala Val Leu Ser Tyr Cys Val Arg Cys Cys Pro Ala
         100                 105                 110

 gga cag gca ctg cgg ctg atc agc tgc aga ttg gtt gct gcg cag gag      500
 Gly Gln Ala Leu Arg Leu Ile Ser Cys Arg Leu Val Ala Ala Gln Glu
     115                 120                 125

 aag aag aag aag agc ctg ggg aag cgg ctc cag gcc agc ctg ggt ggc      548
 Lys Lys Lys Lys Ser Leu Gly Lys Arg Leu Gln Ala Ser Leu Gly Gly
 130                 135                 140                 145

 ggc agt tct caa ggc acc aca aaa caa ctg cca gcc tcc ctt ctt cat      596
 Gly Ser Ser Gln Gly Thr Thr Lys Gln Leu Pro Ala Ser Leu Leu His
                 150                 155                 160

 cca ctc ttt cag gca atg act gac cca ctg tgc cat ctg agc agc ctc      644
 Pro Leu Phe Gln Ala Met Thr Asp Pro Leu Cys His Leu Ser Ser Leu
             165                 170                 175

 acg ctg tcc cac tgc aaa ctc cct gac gcg gtc tgc cga gac ctt tct      692
 Thr Leu Ser His Cys Lys Leu Pro Asp Ala Val Cys Arg Asp Leu Ser
         180                 185                 190

 gag gcc ctg agg gca gcc ccc gca ctg acg gag ctg ggc ctc ctc cac      740
 Glu Ala Leu Arg Ala Ala Pro Ala Leu Thr Glu Leu Gly Leu Leu His
     195                 200                 205

 aac agg ctc agt gag gca gga ctg cgt atg ctg agt gag ggc cta gcc      788
 Asn Arg Leu Ser Glu Ala Gly Leu Arg Met Leu Ser Glu Gly Leu Ala
 210                 215                 220                 225

 tgg ccg cag tgc agg gtg cag acg gtc agg gta cag ctg cct gac ccc      836
 Trp Pro Gln Cys Arg Val Gln Thr Val Arg Val Gln Leu Pro Asp Pro
                 230                 235                 240

 cag cga ggg ctc cag tac ctg gtg ggt atg ctt cgg cag agc ccc gcc      884
 Gln Arg Gly Leu Gln Tyr Leu Val Gly Met Leu Arg Gln Ser Pro Ala
             245                 250                 255

 ctg acc acc ctg gat ctc agt ggc tgc caa ctg ccc gcc ccc atg gtg      932
 Leu Thr Thr Leu Asp Leu Ser Gly Cys Gln Leu Pro Ala Pro Met Val
         260                 265                 270

 acc tac ctg tgt gca gtc ctg cag cac cag gga tgc ggc ctg cag acc      980
 Thr Tyr Leu Cys Ala Val Leu Gln His Gln Gly Cys Gly Leu Gln Thr
     275                 280                 285

 ctc agt ctg gcc tct gtg gag ctg agc gag cag tca cta cag gag ctt     1028
 Leu Ser Leu Ala Ser Val Glu Leu Ser Glu Gln Ser Leu Gln Glu Leu
 290                 295                 300                 305

 cag gct gtg aag aga gca aag ccg gat ctg gtc atc gca cac cca gcg     1076
 Gln Ala Val Lys Arg Ala Lys Pro Asp Leu Val Ile Ala His Pro Ala
                 310                 315                 320

 ctg gac ggc cac cca caa cct ccc aag gaa ctc atc tcg acc ttc tga     1124
 Leu Asp Gly His Pro Gln Pro Pro Lys Glu Leu Ile Ser Thr Phe 
             325                 330                 335

 ggctctggtg gccagagcag ggtggaagac cctagtcaaa a                       1165




      <210> 266
      <211> 4380
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(4380)

      <400> 266
 atgtggcgcc cacccacaga tgccgcagcc tgcggggggt gtgggggcgg gggggcgggg     60

 agtcgtcttg aatctggctt gtgttca    atg acc agt gtt gac cac ggc aga     111
                                  Met Thr Ser Val Asp His Gly Arg
                                    1               5

 gca gca caa gcg gga ggt gct gac ggt ccc tgg gcg cag cgg ctg gac      159
 Ala Ala Gln Ala Gly Gly Ala Asp Gly Pro Trp Ala Gln Arg Leu Asp
      10                  15                  20

 gct ggc ggt ccg agc agc gca tgt gcc ctg ctg ccc gcc aag gac cca      207
 Ala Gly Gly Pro Ser Ser Ala Cys Ala Leu Leu Pro Ala Lys Asp Pro
  25                  30                  35                  40

 gag ccc cct gag ccc ccg ccc acc acg gag ccc tcc cag ggg tgt agg      255
 Glu Pro Pro Glu Pro Pro Pro Thr Thr Glu Pro Ser Gln Gly Cys Arg
                  45                  50                  55

 gcc cgg tgg cgg cgc gct tgg gct ttt cta gcc att gac gaa ccc cgt      303
 Ala Arg Trp Arg Arg Ala Trp Ala Phe Leu Ala Ile Asp Glu Pro Arg
              60                  65                  70

 cct gtt ttt cgg agt ttt gag ggc tca gag ggc cgc ggc ggg agc gga      351
 Pro Val Phe Arg Ser Phe Glu Gly Ser Glu Gly Arg Gly Gly Ser Gly
          75                  80                  85

 tcc ctg gac cct cgc cct ccc tac ccc gca ccc ccg tcc cag cct ggg      399
 Ser Leu Asp Pro Arg Pro Pro Tyr Pro Ala Pro Pro Ser Gln Pro Gly
      90                  95                 100

 cca gag ccg ccg cgg gtc ccg gcg cgg ccg gca ggg ggc gcg cgc gga      447
 Pro Glu Pro Pro Arg Val Pro Ala Arg Pro Ala Gly Gly Ala Arg Gly
 105                 110                 115                 120

 cag acg cct gca ccc gac cct gga act ggc gtc ttt tcc tcg cta atc      495
 Gln Thr Pro Ala Pro Asp Pro Gly Thr Gly Val Phe Ser Ser Leu Ile
                 125                 130                 135

 tgc gag gaa aaa aaa aat gtt ttt cag ggc aac gcg agg gaa gaa ggt      543
 Cys Glu Glu Lys Lys Asn Val Phe Gln Gly Asn Ala Arg Glu Glu Gly
             140                 145                 150

 ggc ggc tcc cac tcg ctt ctc cct cgg gtc ggg tcc gag ctg cca ggc      591
 Gly Gly Ser His Ser Leu Leu Pro Arg Val Gly Ser Glu Leu Pro Gly
         155                 160                 165

 cgc atg cca ctc cct gac ggg gcg cgg acc ccg ggg ggc gtc tgc cgg      639
 Arg Met Pro Leu Pro Asp Gly Ala Arg Thr Pro Gly Gly Val Cys Arg
     170                 175                 180

 gag gcg cgc ggc ggg ggc tac acc aac cgg acc ttc gag ttt gac gac      687
 Glu Ala Arg Gly Gly Gly Tyr Thr Asn Arg Thr Phe Glu Phe Asp Asp
 185                 190                 195                 200

 ggc caa tgc gcc ccc agg cgg ccc tgc gcg ggg gac ggc gcg ctc ctg      735
 Gly Gln Cys Ala Pro Arg Arg Pro Cys Ala Gly Asp Gly Ala Leu Leu
                 205                 210                 215

 gac acc gcc ggc ttc aag atg agc gac ctg gac tcc gag gtg ctg ccc      783
 Asp Thr Ala Gly Phe Lys Met Ser Asp Leu Asp Ser Glu Val Leu Pro
             220                 225                 230

 ttg ccg ccg cgc tac cgc ttc cgg gac ctg ctg ctg ggc gac ccg tcc      831
 Leu Pro Pro Arg Tyr Arg Phe Arg Asp Leu Leu Leu Gly Asp Pro Ser
         235                 240                 245

 ttc cag aac gac gac agg gtc cag gtg gag ttc tac gtc aac gag aac      879
 Phe Gln Asn Asp Asp Arg Val Gln Val Glu Phe Tyr Val Asn Glu Asn
     250                 255                 260

 acc ttc aag gag cgg ctc aag ctg ttc ttc atc aaa aac caa aga tcg      927
 Thr Phe Lys Glu Arg Leu Lys Leu Phe Phe Ile Lys Asn Gln Arg Ser
 265                 270                 275                 280

 agc ctg agg atc cgg ctg ttc aac ttc tcc ctg aag ctg ctc acc tgc      975
 Ser Leu Arg Ile Arg Leu Phe Asn Phe Ser Leu Lys Leu Leu Thr Cys
                 285                 290                 295

 ctg ctc tac att gtg cgc gtc ctg ctc gat gac ccg gcc ctg ggc atc     1023
 Leu Leu Tyr Ile Val Arg Val Leu Leu Asp Asp Pro Ala Leu Gly Ile
             300                 305                 310

 gga tgc tgg ggc tgc cca aag cag aac tac tcc ttc aat gac tcg tcc     1071
 Gly Cys Trp Gly Cys Pro Lys Gln Asn Tyr Ser Phe Asn Asp Ser Ser
         315                 320                 325

 tcc gag atc aac tgg gct cct att ctg tgg gtg gag aga aag atg aca     1119
 Ser Glu Ile Asn Trp Ala Pro Ile Leu Trp Val Glu Arg Lys Met Thr
     330                 335                 340

 ctg tgg gcg atc cag gtc atc gtg gcc ata ata agc ttc ctg gag acg     1167
 Leu Trp Ala Ile Gln Val Ile Val Ala Ile Ile Ser Phe Leu Glu Thr
 345                 350                 355                 360

 atg ctt ctc atc tac ctc agc tac aaa ggc aac atc tgg gag cag atc     1215
 Met Leu Leu Ile Tyr Leu Ser Tyr Lys Gly Asn Ile Trp Glu Gln Ile
                 365                 370                 375

 ttc cgc gtg tcc ttc gtc ctg gag atg atc aac act ctg ccc ttc atc     1263
 Phe Arg Val Ser Phe Val Leu Glu Met Ile Asn Thr Leu Pro Phe Ile
             380                 385                 390

 atc acg atc ttc tgg ccg ccg ctg cgg aac ctg ttc atc ccc gtc ttt     1311
 Ile Thr Ile Phe Trp Pro Pro Leu Arg Asn Leu Phe Ile Pro Val Phe
         395                 400                 405

 ctg aac tgc tgg ctg gcc aag cac gcg ctg gaa aac atg att aat gac     1359
 Leu Asn Cys Trp Leu Ala Lys His Ala Leu Glu Asn Met Ile Asn Asp
     410                 415                 420

 ttc cac cgt gcc atc ctg cgg aca cag tca gcc atg ttc aac cag gtc     1407
 Phe His Arg Ala Ile Leu Arg Thr Gln Ser Ala Met Phe Asn Gln Val
 425                 430                 435                 440

 ctc atc ctc ttc tgc acc ctg ctg tgc ctc gtt ttc acg ggg acc tgc     1455
 Leu Ile Leu Phe Cys Thr Leu Leu Cys Leu Val Phe Thr Gly Thr Cys
                 445                 450                 455

 ggc atc cag cac ctg gag cgg gcg ggc gag aac ctg tcc ctc ctg acc     1503
 Gly Ile Gln His Leu Glu Arg Ala Gly Glu Asn Leu Ser Leu Leu Thr
             460                 465                 470

 tcc ttc tac ttc tgc atc gtc acc ttc tcc acc gtg ggc tac ggt gac     1551
 Ser Phe Tyr Phe Cys Ile Val Thr Phe Ser Thr Val Gly Tyr Gly Asp
         475                 480                 485

 gtc acg ccc aag atc tgg cca tcg cag ctg ctg gtg gtc atc atg atc     1599
 Val Thr Pro Lys Ile Trp Pro Ser Gln Leu Leu Val Val Ile Met Ile
     490                 495                 500

 tgc gtg gcc ctc gtg gtg ctc cca ctg cag ttc gag gag ctc gtc tac     1647
 Cys Val Ala Leu Val Val Leu Pro Leu Gln Phe Glu Glu Leu Val Tyr
 505                 510                 515                 520

 ctc tgg atg gag cgg cag aag tca ggg ggc aac tac agc cgc cac cgt     1695
 Leu Trp Met Glu Arg Gln Lys Ser Gly Gly Asn Tyr Ser Arg His Arg
                 525                 530                 535

 gcg cag acg gag aag cac gtg gtc ctg tgt gtc agc tcc ctc aag atc     1743
 Ala Gln Thr Glu Lys His Val Val Leu Cys Val Ser Ser Leu Lys Ile
             540                 545                 550

 gac ctt ctc atg gac ttc ctg aac gag ttc tac gcc cac ccc cgg ctc     1791
 Asp Leu Leu Met Asp Phe Leu Asn Glu Phe Tyr Ala His Pro Arg Leu
         555                 560                 565

 cag gac tat tac gtg gtc atc ctg tgc ccc acg gag atg gat gtc cag     1839
 Gln Asp Tyr Tyr Val Val Ile Leu Cys Pro Thr Glu Met Asp Val Gln
     570                 575                 580

 gtg cgc aga gtc ctg cag atc cct ctg tgg tcc cag cgg gtc atc tac     1887
 Val Arg Arg Val Leu Gln Ile Pro Leu Trp Ser Gln Arg Val Ile Tyr
 585                 590                 595                 600

 ctc cag ggc tct gca ctc aaa gac cag gac ctc atg cga gcc aag atg     1935
 Leu Gln Gly Ser Ala Leu Lys Asp Gln Asp Leu Met Arg Ala Lys Met
                 605                 610                 615

 gac aat ggg gag gcc tgc ttc atc ctc agc agc agg aac gag gtg gac     1983
 Asp Asn Gly Glu Ala Cys Phe Ile Leu Ser Ser Arg Asn Glu Val Asp
             620                 625                 630

 cgc acg gct gca gac cac cag acc atc ctg cgc gcc tgg gcc gtg aag     2031
 Arg Thr Ala Ala Asp His Gln Thr Ile Leu Arg Ala Trp Ala Val Lys
         635                 640                 645

 gac ttc gcc ccc aac tgc ccc ctc tac gtc cag atc ctc aaa cct gaa     2079
 Asp Phe Ala Pro Asn Cys Pro Leu Tyr Val Gln Ile Leu Lys Pro Glu
     650                 655                 660

 aac aag ttt cac gtc aag ttt gct gac cac gtg gtg tgt gag gag gag     2127
 Asn Lys Phe His Val Lys Phe Ala Asp His Val Val Cys Glu Glu Glu
 665                 670                 675                 680

 tgc aag tac gcc atg ctg gcg ctg aac tgc atc tgc ccg gcg acc tcc     2175
 Cys Lys Tyr Ala Met Leu Ala Leu Asn Cys Ile Cys Pro Ala Thr Ser
                 685                 690                 695

 acc ctc atc acc ctg ctg gtg cac acg tcc cgc ggc cag gag gga cag     2223
 Thr Leu Ile Thr Leu Leu Val His Thr Ser Arg Gly Gln Glu Gly Gln
             700                 705                 710

 gag tct ccg gag cag tgg cag cgc atg tat ggg cgc tgc tcc ggc aac     2271
 Glu Ser Pro Glu Gln Trp Gln Arg Met Tyr Gly Arg Cys Ser Gly Asn
         715                 720                 725

 gag gtg tac cac atc cgc atg ggt gac agc aag ttc ttc cgc gag tac     2319
 Glu Val Tyr His Ile Arg Met Gly Asp Ser Lys Phe Phe Arg Glu Tyr
     730                 735                 740

 gag ggc aag agc ttc acc tac gcg gcc ttc cac gcc cac aag aag tat     2367
 Glu Gly Lys Ser Phe Thr Tyr Ala Ala Phe His Ala His Lys Lys Tyr
 745                 750                 755                 760

 ggc gtg tgc ctc atc ggg ctg aag cgg gag gac aac aag agc atc ctg     2415
 Gly Val Cys Leu Ile Gly Leu Lys Arg Glu Asp Asn Lys Ser Ile Leu
                 765                 770                 775

 ctg aac ccg ggg ccc cgg cac atc ctg gcc gcc tct gac acc tgc ttc     2463
 Leu Asn Pro Gly Pro Arg His Ile Leu Ala Ala Ser Asp Thr Cys Phe
             780                 785                 790

 tac atc aac atc acc aag gag gag aac tcg gcc ttc atc ttc aag cag     2511
 Tyr Ile Asn Ile Thr Lys Glu Glu Asn Ser Ala Phe Ile Phe Lys Gln
         795                 800                 805

 gag gag aag cgg aag aag agg gcc ttc tcg ggg cag ggg ctg cac gag     2559
 Glu Glu Lys Arg Lys Lys Arg Ala Phe Ser Gly Gln Gly Leu His Glu
     810                 815                 820

 ggt ccg gcc cgc ctg ccc gtg cac agc atc atc gcc tcc atg ggg aca     2607
 Gly Pro Ala Arg Leu Pro Val His Ser Ile Ile Ala Ser Met Gly Thr
 825                 830                 835                 840

 gtg gcc atg gac ctg cag ggc aca gag cac cgg cct acg cag agc ggc     2655
 Val Ala Met Asp Leu Gln Gly Thr Glu His Arg Pro Thr Gln Ser Gly
                 845                 850                 855

 ggt ggg ggc ggg ggc agc aag ctg gca ctg ccc acg gag aac ggc tcg     2703
 Gly Gly Gly Gly Gly Ser Lys Leu Ala Leu Pro Thr Glu Asn Gly Ser
             860                 865                 870

 ggc agc cgg cgg ccc agc atc gcg ccc gtc ctg gaa ctg gcc gac agc     2751
 Gly Ser Arg Arg Pro Ser Ile Ala Pro Val Leu Glu Leu Ala Asp Ser
         875                 880                 885

 tca gcc ctg ctg ccc tgc gac ctg ctg agc gac cag tcg gag gat gag     2799
 Ser Ala Leu Leu Pro Cys Asp Leu Leu Ser Asp Gln Ser Glu Asp Glu
     890                 895                 900

 gtg acg ccg tcg gac gac gag ggg ctc tcc gtg gta gag tat gtg aag     2847
 Val Thr Pro Ser Asp Asp Glu Gly Leu Ser Val Val Glu Tyr Val Lys
 905                 910                 915                 920

 ggc tac cct ccc aac tcg ccc tac atc ggc agc tcc cca acc ctg tgc     2895
 Gly Tyr Pro Pro Asn Ser Pro Tyr Ile Gly Ser Ser Pro Thr Leu Cys
                 925                 930                 935

 cac ctc ctg cct gtg aaa gcc ccc ttc tgc tgc ctg cgg ctg gac aag     2943
 His Leu Leu Pro Val Lys Ala Pro Phe Cys Cys Leu Arg Leu Asp Lys
             940                 945                 950

 ggc tgc aag cac aac agc tat gaa gac gcc aag gcc tac ggg ttc aag     2991
 Gly Cys Lys His Asn Ser Tyr Glu Asp Ala Lys Ala Tyr Gly Phe Lys
         955                 960                 965

 aac aag ctg atc atc gtc tcg gca gag acg gcc ggc aat ggg ctg tac     3039
 Asn Lys Leu Ile Ile Val Ser Ala Glu Thr Ala Gly Asn Gly Leu Tyr
     970                 975                 980

 aac ttc atc gtg cca ctg cgg gcc tac tac aga tcc cgc aag gag ctg     3087
 Asn Phe Ile Val Pro Leu Arg Ala Tyr Tyr Arg Ser Arg Lys Glu Leu
 985                 990                 995                1000

 aac ccc atc gtg ctg ctg ctg gac aac aag ccc gac cac cac ttc ctg     3135
 Asn Pro Ile Val Leu Leu Leu Asp Asn Lys Pro Asp His His Phe Leu
                1005                1010                1015

 gaa gcc atc tgc tgc ttc ccc atg gtc tac tac atg gag ggc tct gtg     3183
 Glu Ala Ile Cys Cys Phe Pro Met Val Tyr Tyr Met Glu Gly Ser Val
            1020                1025                1030

 gac aac ctg gac agc ctg ctg cag tgt ggc atc atc tat gcg gac aac     3231
 Asp Asn Leu Asp Ser Leu Leu Gln Cys Gly Ile Ile Tyr Ala Asp Asn
        1035                1040                1045

 ctg gtg gtg gtg gac aag gag agc acc atg agc gcc gag gag gac tac     3279
 Leu Val Val Val Asp Lys Glu Ser Thr Met Ser Ala Glu Glu Asp Tyr
    1050                1055                1060

 atg gcg gac gcc aag acc atc gtc aac gtg cag acc atg ttc cgg ctc     3327
 Met Ala Asp Ala Lys Thr Ile Val Asn Val Gln Thr Met Phe Arg Leu
1065                1070                1075                1080

 ttc ccc agc ctc agc atc acc acg gag ctc acc cac cct tcc aac atg     3375
 Phe Pro Ser Leu Ser Ile Thr Thr Glu Leu Thr His Pro Ser Asn Met
                1085                1090                1095

 cgc ttc atg cag ttc cgc gcc aag gac agc tac tct ctg gct ctt tcc     3423
 Arg Phe Met Gln Phe Arg Ala Lys Asp Ser Tyr Ser Leu Ala Leu Ser
            1100                1105                1110

 aaa cta gaa aag agg gag cga gag aat ggc tcc aac ctg gcc ttc atg     3471
 Lys Leu Glu Lys Arg Glu Arg Glu Asn Gly Ser Asn Leu Ala Phe Met
        1115                1120                1125

 ttc cgc ctg ccg ttc gcc gcc ggc cgc gtc ttc agc atc agc atg ttg     3519
 Phe Arg Leu Pro Phe Ala Ala Gly Arg Val Phe Ser Ile Ser Met Leu
    1130                1135                1140

 gac aca ctg ctc tac cag tcc ttc gtg aag gac tac atg atc acc atc     3567
 Asp Thr Leu Leu Tyr Gln Ser Phe Val Lys Asp Tyr Met Ile Thr Ile
1145                1150                1155                1160

 acc cgg ctg ctg ctg ggc ctg gac acc acg ccg ggc tcg ggg tac ctc     3615
 Thr Arg Leu Leu Leu Gly Leu Asp Thr Thr Pro Gly Ser Gly Tyr Leu
                1165                1170                1175

 tgt gcc atg aaa atc acc gag ggc gac ctg tgg atc cgc acg tac ggc     3663
 Cys Ala Met Lys Ile Thr Glu Gly Asp Leu Trp Ile Arg Thr Tyr Gly
            1180                1185                1190

 cgc ctc ttc cag aag ctc tgc tcc tcc agc gcc gag atc ccc att ggc     3711
 Arg Leu Phe Gln Lys Leu Cys Ser Ser Ser Ala Glu Ile Pro Ile Gly
        1195                1200                1205

 atc tac cgg aca gag agc cac gtc ttc tcc acc tcg gag gtt ctg ggg     3759
 Ile Tyr Arg Thr Glu Ser His Val Phe Ser Thr Ser Glu Val Leu Gly
    1210                1215                1220

 cag cct ggg ggc tgg gac tgt ggc agc ccc tgt cct tcc cag atc tcg     3807
 Gln Pro Gly Gly Trp Asp Cys Gly Ser Pro Cys Pro Ser Gln Ile Ser
1225                1230                1235                1240

 gtg aac gtg gag gac tgt gag gac aca cgg gaa gtg aag ggg ccc tgg     3855
 Val Asn Val Glu Asp Cys Glu Asp Thr Arg Glu Val Lys Gly Pro Trp
                1245                1250                1255

 ggc tcc cgc gct ggc acc gga ggc agc tcc cag ggc cgc cac acg ggc     3903
 Gly Ser Arg Ala Gly Thr Gly Gly Ser Ser Gln Gly Arg His Thr Gly
            1260                1265                1270

 ggc ggt gac ccc gca gag cac cca ctg cta cgg cgc aag agc ctg cag     3951
 Gly Gly Asp Pro Ala Glu His Pro Leu Leu Arg Arg Lys Ser Leu Gln
        1275                1280                1285

 tgg gcc cgg agg ctg agc cgc aag gcg ccc aag cag gca ggc cgg gcg     3999
 Trp Ala Arg Arg Leu Ser Arg Lys Ala Pro Lys Gln Ala Gly Arg Ala
    1290                1295                1300

 gcg gcc gcg gag tgg atc agc cag cag cgc ctc agc ctg tac cgg cgc     4047
 Ala Ala Ala Glu Trp Ile Ser Gln Gln Arg Leu Ser Leu Tyr Arg Arg
1305                1310                1315                1320

 tct gag cgc cag gag ctc tcc gag ctg gtg aag aac cgc atg aag cac     4095
 Ser Glu Arg Gln Glu Leu Ser Glu Leu Val Lys Asn Arg Met Lys His
                1325                1330                1335

 ctg ggg ctg ccc acc acc ggc tac gag gac gta gca aat tta aca gcc     4143
 Leu Gly Leu Pro Thr Thr Gly Tyr Glu Asp Val Ala Asn Leu Thr Ala
            1340                1345                1350

 agt gat gtc atg aat cgg gta aac ctg gga tat ttg caa ggt aat tct     4191
 Ser Asp Val Met Asn Arg Val Asn Leu Gly Tyr Leu Gln Gly Asn Ser
        1355                1360                1365

 gcc ctg gcg ggt gcc gac cac cgc aca acg ggg ctc gcc aac cct tca     4239
 Ala Leu Ala Gly Ala Asp His Arg Thr Thr Gly Leu Ala Asn Pro Ser
    1370                1375                1380

 ccg ccg gca gcc ttg ctg cgc cat ccc ggc cag gca ggc cct cag gca     4287
 Pro Pro Ala Ala Leu Leu Arg His Pro Gly Gln Ala Gly Pro Gln Ala
1385                1390                1395                1400

 cac ctg ctg cca gcc ttc acc aag cac cgt gga cac gcg aag cta gtc     4335
 His Leu Leu Pro Ala Phe Thr Lys His Arg Gly His Ala Lys Leu Val
                1405                1410                1415

 ctc tgc gac cat cct ggg cag cca gga cca gtg cca tgt gac tga         4380
 Leu Cys Asp His Pro Gly Gln Pro Gly Pro Val Pro Cys Asp 
            1420                1425                1430





      <210> 267
      <211> 3482
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(2477)

      <400> 267
 cggacgcgtg ggtccggcgg cctgaggctg caccgggcac gggtcggccg caatccagcc     60

 tgggcggagc cggagttgcg agccgctgcc tagaggccga ggagctcaca gct   atg     116
                                                              Met
                                                                1

 ggc tgg agg ccc cgg aga gct cgg ggg acc ccg ttg ctg ctg ctg cta      164
 Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu Leu
               5                  10                  15

 cta ctg ctg ctg ctc tgg cca gtg cca ggc gcc ggg gtg ctt caa gga      212
 Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln Gly
          20                  25                  30

 cat atc cct ggg cag cca gtc acc ccg cac tgg gtc ctg gat gga caa      260
 His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly Gln
      35                  40                  45

 ccc tgg cgc acc gtc agc ctg gag gag ccg gtc tcg aag cca gac atg      308
 Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp Met
  50                  55                  60                  65

 ggg ctg gtg gcc ctg gag gct gaa ggc cag gag ctc ctg ctt gag ctg      356
 Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu Leu
                  70                  75                  80

 gag aag aac cac agg ctg ctg gcc cca gga tac ata gaa acc cac tac      404
 Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His Tyr
              85                  90                  95

 ggc cca gat ggg cag cca gtg gtg ctg gcc ccc aac cac acg gat cat      452
 Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp His
         100                 105                 110

 tgc cac tac caa ggg cga gta agg ggc ttc ccc gac tcc tgg gta gtc      500
 Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val Val
     115                 120                 125

 ctc tgc acc tgc tct ggg atg agt ggc ctg atc acc ctc agc agg aat      548
 Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg Asn
 130                 135                 140                 145

 gcc agc tat tat ctg cgt ccc tgg cca ccc cgg ggc tcc aag gac ttc      596
 Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp Phe
                 150                 155                 160

 tca acc cac gag atc ttt cgg atg gag cag ctg ctc acc tgg aaa gga      644
 Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys Gly
             165                 170                 175

 acc tgt ggc cac agg gat cct ggg aac aaa gcg ggc atg acc agc ctt      692
 Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser Leu
         180                 185                 190

 cct ggt ggt ccc cag agc agg ggc agg cga gaa gcg cgc agg acc cgg      740
 Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr Arg
     195                 200                 205

 aag tac ctg gaa ctg tac att gtg gca gac cac acc ctg ttc ttg act      788
 Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu Thr
 210                 215                 220                 225

 cgg cac cga aac ttg aac cac acc aaa cag cgt ctc ctg gaa gtc gcc      836
 Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val Ala
                 230                 235                 240

 aac tac gtg gac cag ctt ctc agg act ctg gac att cag gtg gcg ctg      884
 Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala Leu
             245                 250                 255

 acc ggc ctg gag gtg tgg acc gag cgg gac cgc agc cgc gtc acg cag      932
 Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val Thr Gln
         260                 265                 270

 gac gcc aac gcc acg ctc tgg gcc ttc ctg cag tgg cgc cgg ggg ctg      980
 Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg Gly Leu
     275                 280                 285

 tgg gcg cag cgg ccc cac gac tcc gcg cag ctg ctc acg ggc cgc gcc     1028
 Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly Arg Ala
 290                 295                 300                 305

 ttc cag ggc gcc aca gtg ggc ctg gcg ccc gtc gag ggc atg tgc cgc     1076
 Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met Cys Arg
                 310                 315                 320

 gcc gag agc tcg gga ggc gtg agc acg gac cac tcg gag ctc ccc atc     1124
 Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu Pro Ile
             325                 330                 335

 ggc gcc gca gcc acc atg gcc cat gag atc ggc cac agc ctc ggc ctc     1172
 Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu Gly Leu
         340                 345                 350

 agc cac gac ccc gac ggc tgc tgc gtg gag gct gcg gcc gag tcc gga     1220
 Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu Ser Gly
     355                 360                 365

 ggc tgc gtc atg gct gcg gcc acc ggg cac ccg ttt ccg cgc gtg ttc     1268
 Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg Val Phe
 370                 375                 380                 385

 agc gcc tgc agc cgc cgc cag ctg cgc gcc ttc ttc cgc aag ggg ggc     1316
 Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys Gly Gly
                 390                 395                 400

 ggc gct tgc ctc tcc aat gcc ccg gac ccc gga ctc ccg gtg ccg ccg     1364
 Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val Pro Pro
             405                 410                 415

 gcg ctc tgc ggg aac ggc ttc gtg gaa gcg ggc gag gag tgt gac tgc     1412
 Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp Cys
         420                 425                 430

 ggc cct ggc cag gag tgc cgc gac ctc tgc tgc ttt gct cac aac tgc     1460
 Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His Asn Cys
     435                 440                 445

 tcg ctg cgc ccg ggg gcc cag tgc gcc cac ggg gac tgc tgc gtg cgc     1508
 Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys Val Arg
 450                 455                 460                 465

 tgc ctg ctg aag ccg gct gga gcg ctg tgc cgc cag gcc atg ggt gac     1556
 Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met Gly Asp
                 470                 475                 480

 tgt gac ctc cct gag ttt tgc acg ggc acc tcc tcc cac tgt ccc cca     1604
 Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys Pro Pro
             485                 490                 495

 gac gtt tac cta ctg gac ggc tca ccc tgt gcc agg ggc agt ggc tac     1652
 Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly Tyr
         500                 505                 510

 tgc tgg gat ggc gca tgt ccc acg ctg gag cag cag tgc cag cag ctc     1700
 Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln Leu
     515                 520                 525

 tgg ggg cct ggc tcc cac cca gct ccc gag gcc tgt ttc cag gtg gtg     1748
 Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln Val Val
 530                 535                 540                 545

 aac tct gcg gga gat gct cat gga aac tgc ggc cag gac agc gag ggc     1796
 Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser Glu Gly
                 550                 555                 560

 cac ttc ctg ccc tgt gca ggg agg gat gcc ctg tgt ggg aag ctg cag     1844
 His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu Gln
             565                 570                 575

 tgc cag ggt gga aag ccc agc ctg ctc gca ccg cac atg gtg cca gtg     1892
 Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val Pro Val
         580                 585                 590

 gac tct acc gtt cac cta gat ggc cag gaa gtg act tgt cgg gga gcc     1940
 Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg Gly Ala
     595                 600                 605

 ttg gca ctc ccc agt gcc cag ctg gac ctg ctt ggc ctg ggc ctg gta     1988
 Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu Val
 610                 615                 620                 625

 gag cca ggc acc cag tgt gga cct aga atg gtt tgc aat agc aac cat     2036
 Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Asn Ser Asn His
                 630                 635                 640

 aac tgc cac tgt gct cca ggc tgg gct cca ccc ttc tgt gac aag cca     2084
 Asn Cys His Cys Ala Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys Pro
             645                 650                 655

 ggc ttt ggt ggc agc atg gac agt ggc cct gtg cag gct gaa aac cat     2132
 Gly Phe Gly Gly Ser Met Asp Ser Gly Pro Val Gln Ala Glu Asn His
         660                 665                 670

 gac acc ttc ctg ctg gcc atg ctc ctc agc gtc ctg ctg cct ctg ctc     2180
 Asp Thr Phe Leu Leu Ala Met Leu Leu Ser Val Leu Leu Pro Leu Leu
     675                 680                 685

 cca ggg gcc ggc ctg gcc tgg tgt tgc tac cga ctc cca gga gcc cat     2228
 Pro Gly Ala Gly Leu Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala His
 690                 695                 700                 705

 ctg cag cga tgc agc tgg ggc tgc aga agg gac cct gcg tgc agt ggc     2276
 Leu Gln Arg Cys Ser Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser Gly
                 710                 715                 720

 ccc aaa gat ggc cca cac agg gac cac ccc ctg ggc ggc gtt cac ccc     2324
 Pro Lys Asp Gly Pro His Arg Asp His Pro Leu Gly Gly Val His Pro
             725                 730                 735

 atg gag ttg ggc ccc aca gcc act gga cag ccc tgg ccc ctg gac cct     2372
 Met Glu Leu Gly Pro Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp Pro
         740                 745                 750

 gag aac tct cat gag ccc agc agc cac cct gag aag cct ctg cca gca     2420
 Glu Asn Ser His Glu Pro Ser Ser His Pro Glu Lys Pro Leu Pro Ala
     755                 760                 765

 gtc tcg cct gac ccc caa gca gat caa gtc cag atg cca aga tcc tgc     2468
 Val Ser Pro Asp Pro Gln Ala Asp Gln Val Gln Met Pro Arg Ser Cys
 770                 775                 780                 785

 ctc tgg tga gaggtag ctcctaaaat gaacagattt aaagacaggt ggccactgac     2524
 Leu Trp 


 agccactcca ggaacttgaa ctgcaggggc agagccagtg aatcaccgga cctccagcac   2584

 ctgcaggcag cttggaagtt tcttccccga gtggagcttc gacccaccca ctccaggaac   2644

 ccagagccac attagaagtt cctgagggct ggagaacact gcttgggcac actctccagc   2704

 tcaataaacc atcagtccca gaagcaaagg tcacacagcc cctgacctcc ctcaccagtg   2764

 gaggctgggt agtgctggcc atcccaaaag ggctctgtcc tgggagtctg gtgtgtctcc   2824

 tacatgcaat ttccacggac ccagctctgt ggagggcatg actgctggcc agaagctagt   2884

 ggtcctgggg ccctatggtt cgactgagtc cacactcccc tgcagcctgg ctggcctctg   2944

 caaacaaaca taattttggg gaccttcctt cctgtttctt cccaccctgt cttctcccct   3004

 aggtggttcc tgagccccca cccccaatcc cagtgctaca cctgaggttc tggagctcag   3064

 aatctgacag cctctccccc attctgtgtg tgtccggggg acagagggaa ccatttaaga   3124

 aaagatacca aagtagaagt caaaagaaag acatgttggc tataggcgtg gtggctcatg   3184

 cctataatcc cagcactttg ggaagccggg gtaggaggat caccagaggc cagcaggtcc   3244

 acaccagcct gggcaacaca gcaagacacc gcatctacag aaaaatttta aaattagctg   3304

 ggcgtggtgg tgtgtacctg taggcctagc tgctcaggag gctgaagcag gaggatcact   3364

 tgagcctgag ttcaacactg cagtgagcta tggtggcacc actgcactcc agcctgggtg   3424

 acagagcaag accctgtctc taaaataaat tttaaaagga cttaaaaaaa aaaaaaaa     3482




      <210> 268
      <211> 800
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (126)..(566)

      <400> 268
 agcgggggcg gagcgcgggg cgccggctgc tctggcggct cccgcggctc cggctggcgg     60

 cttcgggccc tgcacctgtg actctcggcc gcgctcgccc tcggcccgcc cggcgccgca    120

 gcccc    atg gcc ccg tcc agg ctg cag ctc ggc ctc cgc gcc gcc tac     167
          Met Ala Pro Ser Arg Leu Gln Leu Gly Leu Arg Ala Ala Tyr
            1               5                  10

 tcc ggc atc agc tcc gtg gcc ggc ttc tcc atc ttc ctc gtc tgg acg      215
 Ser Gly Ile Ser Ser Val Ala Gly Phe Ser Ile Phe Leu Val Trp Thr
  15                  20                  25                  30

 gtg gtc tac cga cag ccg ggg acc gcg gcc atg gga ggg ctc gca ggg      263
 Val Val Tyr Arg Gln Pro Gly Thr Ala Ala Met Gly Gly Leu Ala Gly
                  35                  40                  45

 gtg ctg gca ctg tgg gtc ctg gtg acg cac gtg atg tac atg caa gat      311
 Val Leu Ala Leu Trp Val Leu Val Thr His Val Met Tyr Met Gln Asp
              50                  55                  60

 tat tgg agg acc tgg ctc aag ggg ctg cgc ggc ttc ttc ttc gtg ggc      359
 Tyr Trp Arg Thr Trp Leu Lys Gly Leu Arg Gly Phe Phe Phe Val Gly
          65                  70                  75

 gtc ctc ttc tcg gcc gtc tcc atc gct gcc ttc tgc acc ttc ctc gtg      407
 Val Leu Phe Ser Ala Val Ser Ile Ala Ala Phe Cys Thr Phe Leu Val
      80                  85                  90

 ctg gcc atc acc cgg cat cag agc ctc aca gac ccc acc agc tac tac      455
 Leu Ala Ile Thr Arg His Gln Ser Leu Thr Asp Pro Thr Ser Tyr Tyr
  95                 100                 105                 110

 ctc tcc agc gtc tgg agc ttc att tcc ttc aag tgg gcc ttc ctg ctc      503
 Leu Ser Ser Val Trp Ser Phe Ile Ser Phe Lys Trp Ala Phe Leu Leu
                 115                 120                 125

 agc ctc tat gcc cac cgc tac cgg gct gac ttt gct gac atc agc atc      551
 Ser Leu Tyr Ala His Arg Tyr Arg Ala Asp Phe Ala Asp Ile Ser Ile
             130                 135                 140

 ctc agc gat ttc tga cccagggggt gaggtctctg caccctgggg gggccttagg      606
 Leu Ser Asp Phe 
         145

 acctggactc agcctctgag atgttgggag aggctactcc caccccctgg tgaccccaga    666

 actgtggcag aaaatacaca gcaggacgag tgtggtctcc caggaagctg tcctgcccgt    726

 cccctttcga ggaaacctga gtgtggtaga gaggggatcc tgccatgttg ctcctcatca    786

 gcctggccag aggg                                                      800




      <210> 269
      <211> 1924
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1515)

      <400> 269
  atg gcc ctg cag aat gcc ctc tac acc ggg gac ctg gca agg ttg cag      48
  Met Ala Leu Gln Asn Ala Leu Tyr Thr Gly Asp Leu Ala Arg Leu Gln
    1               5                  10                  15

 gag ctg ttc ccc ccg cac agc aca gcc gac ctg ctg ctg gag agc cgg       96
 Glu Leu Phe Pro Pro His Ser Thr Ala Asp Leu Leu Leu Glu Ser Arg
              20                  25                  30

 gcc gca gag cct cgc tgg agc agc cac cag agg gaa gag tgc aag ggg      144
 Ala Ala Glu Pro Arg Trp Ser Ser His Gln Arg Glu Glu Cys Lys Gly
          35                  40                  45

 cag gga gag ccc ctc gat gac aga cac ccc ctc tgt gcc agg ctg gtg      192
 Gln Gly Glu Pro Leu Asp Asp Arg His Pro Leu Cys Ala Arg Leu Val
      50                  55                  60

 gag aag ccc agc aga ggg tct gag gag cac ctc aag tct ggc ccg gga      240
 Glu Lys Pro Ser Arg Gly Ser Glu Glu His Leu Lys Ser Gly Pro Gly
  65                  70                  75                  80

 ccc atc gtc acc cgc aca gcc tca gga cct gcc ctt gcc ttc tgg cag      288
 Pro Ile Val Thr Arg Thr Ala Ser Gly Pro Ala Leu Ala Phe Trp Gln
                  85                  90                  95

 gca gtg ctg gct ggg gac gtg ggc tgt gtc tcc cgc atc ctc gcg gac      336
 Ala Val Leu Ala Gly Asp Val Gly Cys Val Ser Arg Ile Leu Ala Asp
             100                 105                 110

 tcc agt act ggc ctg gct cct gat tcc gtc ttt gat acc agc gac cca      384
 Ser Ser Thr Gly Leu Ala Pro Asp Ser Val Phe Asp Thr Ser Asp Pro
         115                 120                 125

 gag cga tgg agg gat ttc cgc ttc aac atc cgt gct ctg aga ctc tgg      432
 Glu Arg Trp Arg Asp Phe Arg Phe Asn Ile Arg Ala Leu Arg Leu Trp
     130                 135                 140

 tct ctg aca tac gaa gag gag ctg acc acc cca ctg cat gtg gca gcc      480
 Ser Leu Thr Tyr Glu Glu Glu Leu Thr Thr Pro Leu His Val Ala Ala
 145                 150                 155                 160

 agc cgt ggc cac acg gaa gtc ctg cgg ctg ctg ctg agg cgg cga gca      528
 Ser Arg Gly His Thr Glu Val Leu Arg Leu Leu Leu Arg Arg Arg Ala
                 165                 170                 175

 agg cca gac agt gcc cct ggg ggc cgc acc gcc ctg cac gag gcc tgt      576
 Arg Pro Asp Ser Ala Pro Gly Gly Arg Thr Ala Leu His Glu Ala Cys
             180                 185                 190

 gct gca ggc cac act gcc tgt gtt cat gtg ctg ctg gtg gca gga gcc      624
 Ala Ala Gly His Thr Ala Cys Val His Val Leu Leu Val Ala Gly Ala
         195                 200                 205

 gac ccc aac atc gct gac cag gat ggg aaa cgc ccc ctg cat ctc tgc      672
 Asp Pro Asn Ile Ala Asp Gln Asp Gly Lys Arg Pro Leu His Leu Cys
     210                 215                 220

 cgg ggg cct ggc acc ctt gag tgt gcg gag ctg ctc ctc agg ttt gga      720
 Arg Gly Pro Gly Thr Leu Glu Cys Ala Glu Leu Leu Leu Arg Phe Gly
 225                 230                 235                 240

 gcg aga gtg gat ggt cgg tcc gag gaa gaa gag gag acc cct ttg cat      768
 Ala Arg Val Asp Gly Arg Ser Glu Glu Glu Glu Glu Thr Pro Leu His
                 245                 250                 255

 gtg gcc gcc cgg ctt ggc cat gtg gag ctg gca gat ctg ctt cta aga      816
 Val Ala Ala Arg Leu Gly His Val Glu Leu Ala Asp Leu Leu Leu Arg
             260                 265                 270

 cgg ggg gca tgt cct gat gcc cgc aat gcc gaa ggc tgg acc cca ctg      864
 Arg Gly Ala Cys Pro Asp Ala Arg Asn Ala Glu Gly Trp Thr Pro Leu
         275                 280                 285

 ctg gct gcc tgt gac gtc cgc tgc cag tcc atc acc gat gcc gag gcc      912
 Leu Ala Ala Cys Asp Val Arg Cys Gln Ser Ile Thr Asp Ala Glu Ala
     290                 295                 300

 acc acc gcc cgc tgc ctg cag ctg tgc agc ttg ctg ctt tca gct gga      960
 Thr Thr Ala Arg Cys Leu Gln Leu Cys Ser Leu Leu Leu Ser Ala Gly
 305                 310                 315                 320

 gca gac gct gat gct gcc gac cag gac aag cag cga ccc ctg cac ctg     1008
 Ala Asp Ala Asp Ala Ala Asp Gln Asp Lys Gln Arg Pro Leu His Leu
                 325                 330                 335

 gcc tgc cgc cgt ggc cat gca gct gtc gtg gag ctg ctc ctg tcc tgt     1056
 Ala Cys Arg Arg Gly His Ala Ala Val Val Glu Leu Leu Leu Ser Cys
             340                 345                 350

 ggt gtc agc gcc aac acc atg gac tat ggg gga cac acg ccc ctg cac     1104
 Gly Val Ser Ala Asn Thr Met Asp Tyr Gly Gly His Thr Pro Leu His
         355                 360                 365

 tgt gct ctg cag ggc cca gct gca gcc ctg gcc cag agc ccc gag cac     1152
 Cys Ala Leu Gln Gly Pro Ala Ala Ala Leu Ala Gln Ser Pro Glu His
     370                 375                 380

 gtg gtt cgg gct ctg ctc aac cat ggc gcc gtc cgt gtc tgg cca ggg     1200
 Val Val Arg Ala Leu Leu Asn His Gly Ala Val Arg Val Trp Pro Gly
 385                 390                 395                 400

 gcc ctc ccc aag gta gtg ctg gag cgc tgg agc acg tgc cct cgg acc     1248
 Ala Leu Pro Lys Val Val Leu Glu Arg Trp Ser Thr Cys Pro Arg Thr
                 405                 410                 415

 atc gag gtc ctg atg aac acc tac agt gtt gtg cag ctt ccc gag gag     1296
 Ile Glu Val Leu Met Asn Thr Tyr Ser Val Val Gln Leu Pro Glu Glu
             420                 425                 430

 gcc gtc ggc ctg gtg act cct gaa act ctg cag aaa cat cag cgt ttc     1344
 Ala Val Gly Leu Val Thr Pro Glu Thr Leu Gln Lys His Gln Arg Phe
         435                 440                 445

 tac tcc tcc ctc ttc gcc ttg gtg agg cag ccc agg tcg ctg cag cat     1392
 Tyr Ser Ser Leu Phe Ala Leu Val Arg Gln Pro Arg Ser Leu Gln His
     450                 455                 460

 ttg agc cgc tgt gcg ctc cgc tcc cac ctg gag ggc agc ctg ccc caa     1440
 Leu Ser Arg Cys Ala Leu Arg Ser His Leu Glu Gly Ser Leu Pro Gln
 465                 470                 475                 480

 gcg ctg ccc cgc ctc ccc ctg cca ccg cgc ctg ctc cgc tac ctg cag     1488
 Ala Leu Pro Arg Leu Pro Leu Pro Pro Arg Leu Leu Arg Tyr Leu Gln
                 485                 490                 495

 ctg gat ttt gag ggc gtg ctc tac tag atgtc cacggccttt tgagagggcc     1540
 Leu Asp Phe Glu Gly Val Leu Tyr 
             500

 tgaaagcaga tgccccagcc tgcagagggc gcgcctctgc actaactctg gcccggtagc   1600

 cctgccagca ggaggctcag ctccgcagca ggtctggatg ctgcaatgtc catggccttt   1660

 tgagagggcc tgaaagcaga tgccccagcc tgcagagggc gcgcctctgc actaactcag   1720

 gccaggtagc cctggcagca ggaggcccag ctccgcaggc aggtgtggat gctgcaattc   1780

 ccaatgcaga gaagcggacc gacagcggca gccgggtgat gtctgatgaa gacacactcc   1840

 tactggggct ctcctgaggc ccccttctag cctgtgcaaa ccctgtatgt gcattaaaaa   1900

 tctccagttc tgtgaaaaaa ataa                                          1924




      <210> 270
      <211> 1128
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (392)..(907)

      <400> 270
 cagggccgca cagcaggagg taagcaggcc aaccaacaag cattaacgcc tgagctctgc     60

 ctcctgtcag atcagcagtg gcattggatt ctcaaaagag caggaaccct attgtgaagt    120

 gcagatgcga aggatctagg ttgtggtctc ctaatgagaa tctaatgcct ctgaaagcat    180

 tccctccctg accccatttt tcgtggaaaa attatcttcc accaaactgg tggccaaaag    240

 gttgtggatg ctgatataga agacatgtaa atgaaaacaa taaatggaat taaaaattta    300

 gagaaatgct cagaaaaatg aaaactattt gtgctccatt aaagccatgc atagatagaa    360

 tgtcttcata gaacctagga tccaaggttc t   atg aag acc tca gct caa cca     412
                                      Met Lys Thr Ser Ala Gln Pro
                                        1               5

 ggc caa aag cat cct gat ttc tca atg gcc ctc ctc ttc cct cta ctg      460
 Gly Gln Lys His Pro Asp Phe Ser Met Ala Leu Leu Phe Pro Leu Leu
          10                  15                  20

 gca gcc cta gag gtg tgc agc tgt ggc tct tct gga tct cta gga tat      508
 Ala Ala Leu Glu Val Cys Ser Cys Gly Ser Ser Gly Ser Leu Gly Tyr
      25                  30                  35

 aac ctg cct cag aac cat ggc ctg cta ggc agg aac acc ttg gtg ctt      556
 Asn Leu Pro Gln Asn His Gly Leu Leu Gly Arg Asn Thr Leu Val Leu
  40                  45                  50                  55

 ttg ggc caa atg agg aga atc tct ccc ttc ttg tgt cta aag gac aga      604
 Leu Gly Gln Met Arg Arg Ile Ser Pro Phe Leu Cys Leu Lys Asp Arg
                  60                  65                  70

 agt gac ttc aga ttc ccc cag gag aag gtg gaa gtc atc cag ttg cag      652
 Ser Asp Phe Arg Phe Pro Gln Glu Lys Val Glu Val Ile Gln Leu Gln
              75                  80                  85

 aag gcc cat gct atg tct ttc ctc tat gat gtg tta cag cag gtc ttc      700
 Lys Ala His Ala Met Ser Phe Leu Tyr Asp Val Leu Gln Gln Val Phe
          90                  95                 100

 aac ttc tca cac aaa gcg ctc ctc tgc tgc atg gaa cat gac ctt cct      748
 Asn Phe Ser His Lys Ala Leu Leu Cys Cys Met Glu His Asp Leu Pro
     105                 110                 115

 gga cca act cca cac ttt acg tca tca gca gct gga aca cct gga gac      796
 Gly Pro Thr Pro His Phe Thr Ser Ser Ala Ala Gly Thr Pro Gly Asp
 120                 125                 130                 135

 ctg ctt ggt gca gga gat ggg aga agg aga agc tgg ggg cag tgg gtg      844
 Leu Leu Gly Ala Gly Asp Gly Arg Arg Arg Ser Trp Gly Gln Trp Val
                 140                 145                 150

 att gag ggc tct aca ctg gcc ttg agg agg tat ttc cag gaa tcc atc      892
 Ile Glu Gly Ser Thr Leu Ala Leu Arg Arg Tyr Phe Gln Glu Ser Ile
             155                 160                 165

 tct acc ttg gaa tga atcctctgtc ctccagagtt tggttttgtg tccacaacac      947
 Ser Thr Leu Glu 
         170

 attctttgtc caatcagcat tgctatcgtg gaagttttga tttcactcaa ccacacggta   1007

 tgaggaccag aaaccaagct cctcctggga ggccgccctg gtccccgaga ggggcgcgcg   1067

 ggagtggacg ttcccgcacc ttcgccacga aatcgtcgac ccggaaattc cgggcggtat   1127

 c                                                                   1128




      <210> 271
      <211> 1187
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (218)..(1096)

      <400> 271
 gaattcctct tctggaaaag ctgggaagcc tccgtgtgga gccacaaaga ggtccatcgc     60

 tgacagtgaa gaatcggagg cctacaagtc cctctttacc actcacagct ccgccaagcg    120

 ctccaaggag gagtctgccc actgggtcac ccacacgtcc tactgcttct gaagcccgca    180

 ctgccaccgc tcctgcccca gaagctccac ggggcac atg gca tct ccc tct gct     235
                                          Met Ala Ser Pro Ser Ala
                                            1               5

 cat cac aat gtc tgg atc aaa caa atg aaa aac aaa aac atg atg gcc      283
 His His Asn Val Trp Ile Lys Gln Met Lys Asn Lys Asn Met Met Ala
              10                  15                  20

 tct ccc agc aaa gct cca ggg ttg gaa aga gtc ccc tgg cag gga att      331
 Ser Pro Ser Lys Ala Pro Gly Leu Glu Arg Val Pro Trp Gln Gly Ile
          25                  30                  35

 ggc acc ccg tcg tgc cca tcc tct ctc tct gac tgc ctg ctg gaa atg      379
 Gly Thr Pro Ser Cys Pro Ser Ser Leu Ser Asp Cys Leu Leu Glu Met
      40                  45                  50

 ccc cca tct ccc ttt gag tcc tcc tcc tgg gca acc cct gtg acc tgt      427
 Pro Pro Ser Pro Phe Glu Ser Ser Ser Trp Ala Thr Pro Val Thr Cys
  55                  60                  65                  70

 aac ctc tgt cct gaa atc atc aca atg gcc agg gtg gcc tca gct cag      475
 Asn Leu Cys Pro Glu Ile Ile Thr Met Ala Arg Val Ala Ser Ala Gln
                  75                  80                  85

 ggc ctc tgt gac atc acc aag ggc ctg gca cca ggt gcc cag tct tcc      523
 Gly Leu Cys Asp Ile Thr Lys Gly Leu Ala Pro Gly Ala Gln Ser Ser
              90                  95                 100

 agt tgc gag ggc aag caa acc cgt cat gag caa ctc cct tcc cca tct      571
 Ser Cys Glu Gly Lys Gln Thr Arg His Glu Gln Leu Pro Ser Pro Ser
         105                 110                 115

 ctg ctc acc atg tgg acg ctg aaa tcg tcc ctg gtc ctg ctt ctg tgc      619
 Leu Leu Thr Met Trp Thr Leu Lys Ser Ser Leu Val Leu Leu Leu Cys
     120                 125                 130

 ctc acc tgc agc tat gcc ttt atg ttc tct tct ctg aga cag aaa act      667
 Leu Thr Cys Ser Tyr Ala Phe Met Phe Ser Ser Leu Arg Gln Lys Thr
 135                 140                 145                 150

 agc gaa ccc cag ggg aag gtg caa tac gga gag cac ttt cgg att cgg      715
 Ser Glu Pro Gln Gly Lys Val Gln Tyr Gly Glu His Phe Arg Ile Arg
                 155                 160                 165

 cag aat cta cca gag cac acc caa ggc tgg ctt ggg agc aaa tgg ctc      763
 Gln Asn Leu Pro Glu His Thr Gln Gly Trp Leu Gly Ser Lys Trp Leu
             170                 175                 180

 tgg ctt ctt ttt gtt gtt gtg ccg ttt gtg ata ctg cag tgt caa aga      811
 Trp Leu Leu Phe Val Val Val Pro Phe Val Ile Leu Gln Cys Gln Arg
         185                 190                 195

 gac agt gag aag aat aag gag cag agt cct cct ggc ctt cga ggc ggc      859
 Asp Ser Glu Lys Asn Lys Glu Gln Ser Pro Pro Gly Leu Arg Gly Gly
     200                 205                 210

 caa ctt cac tct cca tta aag aaa aaa aga aat gct tcc ccc aac aaa      907
 Gln Leu His Ser Pro Leu Lys Lys Lys Arg Asn Ala Ser Pro Asn Lys
 215                 220                 225                 230

 gac tgt gca ttc aat acc tta atg gaa ctc gag gtg gag ctt atg aaa      955
 Asp Cys Ala Phe Asn Thr Leu Met Glu Leu Glu Val Glu Leu Met Lys
                 235                 240                 245

 ttt gtg tcc aaa gtg cgg aat ctt aaa cgt gcc atg gca aca ggt agt     1003
 Phe Val Ser Lys Val Arg Asn Leu Lys Arg Ala Met Ala Thr Gly Ser
             250                 255                 260

 ggc agt aac ctc agg ctt cga aag tca gag atg cct gca gat cca tac     1051
 Gly Ser Asn Leu Arg Leu Arg Lys Ser Glu Met Pro Ala Asp Pro Tyr
         265                 270                 275

 cat gtc acg atc tgt gaa ata tgg gga gaa gaa agc tct agc tga atg     1099
 His Val Thr Ile Cys Glu Ile Trp Gly Glu Glu Ser Ser Ser 
     280                 285                 290

 gatttgtgtg tcaggagaga aaaaagttga gtgttgacaa actgtatgca aactaataaa   1159

 actattctga agaaaagaaa aaaaaaaa                                      1187




      <210> 272
      <211> 1019
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(605)

      <400> 272
 ggaacccata cttgctggtc tgatcc atg cac aag gcg ggg ctg cta ggc ctc      53
                              Met His Lys Ala Gly Leu Leu Gly Leu
                                1               5

 tgt gcc cgg gct tgg aat tcg gtg cgg atg gcc agc tcc ggg atg acc      101
 Cys Ala Arg Ala Trp Asn Ser Val Arg Met Ala Ser Ser Gly Met Thr
  10                  15                  20                  25

 cgc cgg gac ccg ctc gca aat aag gtg gcc ctg gta acg gcc tcc acc      149
 Arg Arg Asp Pro Leu Ala Asn Lys Val Ala Leu Val Thr Ala Ser Thr
                  30                  35                  40

 gac ggg atc ggc ttc gcc atc gcc cgg cgt ttg gcc cag gac ggg gcc      197
 Asp Gly Ile Gly Phe Ala Ile Ala Arg Arg Leu Ala Gln Asp Gly Ala
              45                  50                  55

 cat gtg gtc gtc agc agc cgg aag cag cag aat gtg gac cag gcg gtg      245
 His Val Val Val Ser Ser Arg Lys Gln Gln Asn Val Asp Gln Ala Val
          60                  65                  70

 gcc acg ctg cag ggg gag ggg ctg agc gtg acg ggc acc gtg tgc cat      293
 Ala Thr Leu Gln Gly Glu Gly Leu Ser Val Thr Gly Thr Val Cys His
      75                  80                  85

 gtg ggg aag gcg gag gac cgg gag cgg ctg gtg gcc acg gct gtg aag      341
 Val Gly Lys Ala Glu Asp Arg Glu Arg Leu Val Ala Thr Ala Val Lys
  90                  95                 100                 105

 ctt cat gga ggt atc gat atc cta gtc tcc aat gct gct gtc aac cct      389
 Leu His Gly Gly Ile Asp Ile Leu Val Ser Asn Ala Ala Val Asn Pro
                 110                 115                 120

 ttc ttt gga agc ata atg gat gtc act gag gag gtg tgg gac aag ctc      437
 Phe Phe Gly Ser Ile Met Asp Val Thr Glu Glu Val Trp Asp Lys Leu
             125                 130                 135

 tgg atg gac aag gaa aaa gag gaa agc atg aaa gaa acc ctg cgg ata      485
 Trp Met Asp Lys Glu Lys Glu Glu Ser Met Lys Glu Thr Leu Arg Ile
         140                 145                 150

 aga agg tta ggc gag cca gag gat tgt gct ggc atc gtg tct ttc ctg      533
 Arg Arg Leu Gly Glu Pro Glu Asp Cys Ala Gly Ile Val Ser Phe Leu
     155                 160                 165

 tgc tct gaa gat gcc agc tac atc act ggg gaa aca gtg gtg gtg ggt      581
 Cys Ser Glu Asp Ala Ser Tyr Ile Thr Gly Glu Thr Val Val Val Gly
 170                 175                 180                 185

 gga gga acc ccg tcc cgc ctc tga ggaccgggag acagcccaca ggccagagtt     635
 Gly Gly Thr Pro Ser Arg Leu 
                 190

 gggctctagc tcctggtgct gttcctgcat tcacccactg gcctttccca cctctgctca    695

 ccttactgtt cacctcatca aatcagttct gccctgtgaa aagatccagc cttccctgcc    755

 gtcaaggtgg cgtcttactc gggattcctg ctgttgttgt ggccttgggt aaaggcctcc    815

 cctgagaaca caggacaggc ctgctgacaa ggctgagtct accttggcaa agaccaagat    875

 attttttcct gggccactgg ggaatctgag gggtgatggg agagaaggaa cctggagtgg    935

 aaggagcaga gttgcaaatt aacaacttgt aaatgaggtg caaataaaat gcagatgatt    995

 gcgcggcttt gaaaaaaaaa aaaa                                          1019




      <210> 273
      <211> 1749
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1446)

      <400> 273
  atg cag gcc cag gac ggg ctc cag gtg tcg ccg gcc cag gac ggg cac      48
  Met Gln Ala Gln Asp Gly Leu Gln Val Ser Pro Ala Gln Asp Gly His
    1               5                  10                  15

 cag gtg acg ctg gcc cag gac ggg ctc cag gtg acg cag acc cag gac       96
 Gln Val Thr Leu Ala Gln Asp Gly Leu Gln Val Thr Gln Thr Gln Asp
              20                  25                  30

 gag ctc cac gtg acg cag gca cag gac tgg ctt cag gtg tcg ctg gca      144
 Glu Leu His Val Thr Gln Ala Gln Asp Trp Leu Gln Val Ser Leu Ala
          35                  40                  45

 cag gac ggg ctt cag atg tgc act cct gac gct ggg aat tca ccc gac      192
 Gln Asp Gly Leu Gln Met Cys Thr Pro Asp Ala Gly Asn Ser Pro Asp
      50                  55                  60

 tgg gcc agt gcc att cgc gtc gca gct ctg gac tgc atg gaa gag aag      240
 Trp Ala Ser Ala Ile Arg Val Ala Ala Leu Asp Cys Met Glu Glu Lys
  65                  70                  75                  80

 aac cag gcc gtg tgc cat gac tac gac atc cac ttc tac ccc acc ttc      288
 Asn Gln Ala Val Cys His Asp Tyr Asp Ile His Phe Tyr Pro Thr Phe
                  85                  90                  95

 cgg gct ggg acg ggg ctg ctg tcc ctg ggt gta tgc ctg ccc cac gag      336
 Arg Ala Gly Thr Gly Leu Leu Ser Leu Gly Val Cys Leu Pro His Glu
             100                 105                 110

 gac agc cgc aca cac agc tct gac cct ggt gtg ctt ccg gca gga cct      384
 Asp Ser Arg Thr His Ser Ser Asp Pro Gly Val Leu Pro Ala Gly Pro
         115                 120                 125

 gac cga gag ctg cga aca gtc aga cag acg atg att gac ttc ctg cag      432
 Asp Arg Glu Leu Arg Thr Val Arg Gln Thr Met Ile Asp Phe Leu Gln
     130                 135                 140

 aac cac acg gaa gga agc cgg ccc cct gcc tgc ccg cgc cta gac ccc      480
 Asn His Thr Glu Gly Ser Arg Pro Pro Ala Cys Pro Arg Leu Asp Pro
 145                 150                 155                 160

 att cag ccc agt gat gtt ctt tcc ctt ctt gac aac cgt ggc agc cat      528
 Ile Gln Pro Ser Asp Val Leu Ser Leu Leu Asp Asn Arg Gly Ser His
                 165                 170                 175

 tac gtg gct att gtc ttt gaa agc aac agc tcc tac ctt gga cgg gag      576
 Tyr Val Ala Ile Val Phe Glu Ser Asn Ser Ser Tyr Leu Gly Arg Glu
             180                 185                 190

 gtg atc tta gac ctg atc ccg tat gaa agc atc gtg gtg acc cga gca      624
 Val Ile Leu Asp Leu Ile Pro Tyr Glu Ser Ile Val Val Thr Arg Ala
         195                 200                 205

 ctg gac ggg gac aaa gca ttt ctg gag aaa ctt ggt gtt tct tca gtc      672
 Leu Asp Gly Asp Lys Ala Phe Leu Glu Lys Leu Gly Val Ser Ser Val
     210                 215                 220

 cct tcg tgt tac ctg atc tac cca aat ggg tcg cat gga ttg att aac      720
 Pro Ser Cys Tyr Leu Ile Tyr Pro Asn Gly Ser His Gly Leu Ile Asn
 225                 230                 235                 240

 gtg tcg aag ctg tac acg gtg gac ctg gag tca ggg cta cac tac ctc      768
 Val Ser Lys Leu Tyr Thr Val Asp Leu Glu Ser Gly Leu His Tyr Leu
                 245                 250                 255

 ctg cgg gtg gag ctg gca gcc cac aag tcc ctg gcc gga gca gag ctg      816
 Leu Arg Val Glu Leu Ala Ala His Lys Ser Leu Ala Gly Ala Glu Leu
             260                 265                 270

 aag acg ctc aag gac ttt gtg act gtc ttg gcc aag ctg ttc cct gga      864
 Lys Thr Leu Lys Asp Phe Val Thr Val Leu Ala Lys Leu Phe Pro Gly
         275                 280                 285

 cgg ccg cca gtc aag aag ctg ttg gag atg ctg cag gag tgg ctg gcc      912
 Arg Pro Pro Val Lys Lys Leu Leu Glu Met Leu Gln Glu Trp Leu Ala
     290                 295                 300

 agc ctt ccc ctg gac agg atc ccc tac aac gcc gtg ctt gac ctg gtc      960
 Ser Leu Pro Leu Asp Arg Ile Pro Tyr Asn Ala Val Leu Asp Leu Val
 305                 310                 315                 320

 aac aac aag atg cgg att tct gga ata ttc ctt act aat cac ata aag     1008
 Asn Asn Lys Met Arg Ile Ser Gly Ile Phe Leu Thr Asn His Ile Lys
                 325                 330                 335

 tgg gtt gga tgt caa gga agc cga tct gag ttg agg ggt tac ccg tgt     1056
 Trp Val Gly Cys Gln Gly Ser Arg Ser Glu Leu Arg Gly Tyr Pro Cys
             340                 345                 350

 tct ctc tgg aaa ctg ttc cac act ttg act gtt gaa gcc tcg acc cac     1104
 Ser Leu Trp Lys Leu Phe His Thr Leu Thr Val Glu Ala Ser Thr His
         355                 360                 365

 cca gat gca ctg gtt ggc aca ggc ttt gaa gac gac ccc cag gct gtg     1152
 Pro Asp Ala Leu Val Gly Thr Gly Phe Glu Asp Asp Pro Gln Ala Val
     370                 375                 380

 ctg cag aca atg agg agg tac gtt cac acc ttc ttt ggg tgt aag gaa     1200
 Leu Gln Thr Met Arg Arg Tyr Val His Thr Phe Phe Gly Cys Lys Glu
 385                 390                 395                 400

 tgt ggt gag cac ttt gag gaa atg gct aaa gaa tcc atg gac tcg gtg     1248
 Cys Gly Glu His Phe Glu Glu Met Ala Lys Glu Ser Met Asp Ser Val
                 405                 410                 415

 aaa acc cca gac caa gcc atc ctc tgg ctg tgg aag aag cat aat atg     1296
 Lys Thr Pro Asp Gln Ala Ile Leu Trp Leu Trp Lys Lys His Asn Met
             420                 425                 430

 gtg aac ggc cgc ctg gca ggt gag aag ccc ctg ggc atg ggg ggc tca     1344
 Val Asn Gly Arg Leu Ala Gly Glu Lys Pro Leu Gly Met Gly Gly Ser
         435                 440                 445

 gca cgg gcg gag gga ggc cct ggt cct ggg aca gca agg acg gca cgg     1392
 Ala Arg Ala Glu Gly Gly Pro Gly Pro Gly Thr Ala Arg Thr Ala Arg
     450                 455                 460

 ctg ccg tgg ggc ttg tcc ctg agc ttt gcg gcc tcg tgc cac cca ctg     1440
 Leu Pro Trp Gly Leu Ser Leu Ser Phe Ala Ala Ser Cys His Pro Leu
 465                 470                 475                 480

 tgc tga cgggatcagg acttgggtgg ctgagagctg ccagagctgc agcctttccc      1496
 Cys 


 aggctgcttc tgtccccggc tttctagatg cttctctcac tccgggggct cttcgacccc   1556

 gtggaaatgg gtgtggctct ttcttccccc atcggtaccc actggtagcc cgttagactc   1616

 tgaagatgtt tttgactctg gaaagcttgg aacgtaatta atttttgatg aggaatttta   1676

 gtagtatgga aatctgttgt ccaaacgtaa accaaacctc tcaaagtgct ttgttttgtt   1736

 aaaaaaaaaa aaa                                                      1749




      <210> 274
      <211> 1347
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1281)

      <400> 274
  atg gcc ggc ctg ggg ttt tgg ggc cac cct gct gga cct ctc ctg ctg      48
  Met Ala Gly Leu Gly Phe Trp Gly His Pro Ala Gly Pro Leu Leu Leu
    1               5                  10                  15

 ctg ctg ctg ctg gtg ctg cca ccc cgg gcc ctg cca gaa gga ccc ctg       96
 Leu Leu Leu Leu Val Leu Pro Pro Arg Ala Leu Pro Glu Gly Pro Leu
              20                  25                  30

 gtg ttc gtg gct ctg gta ttc cgc cat ggc gac cgg gcc ccg ctg gcc      144
 Val Phe Val Ala Leu Val Phe Arg His Gly Asp Arg Ala Pro Leu Ala
          35                  40                  45

 tcc tac ccc atg gac cca cac aag gag gtg gcc tcc acc ctg tgg cca      192
 Ser Tyr Pro Met Asp Pro His Lys Glu Val Ala Ser Thr Leu Trp Pro
      50                  55                  60

 cga ggc ctg ggc cag ctg acc acg gag ggg gtc cgc cag cag ctg gag      240
 Arg Gly Leu Gly Gln Leu Thr Thr Glu Gly Val Arg Gln Gln Leu Glu
  65                  70                  75                  80

 ctg ggc cgc ttc ctg agg agc cgc tac gag gcc ttc ctg agt ccg gag      288
 Leu Gly Arg Phe Leu Arg Ser Arg Tyr Glu Ala Phe Leu Ser Pro Glu
                  85                  90                  95

 tac cgg cgg gag gag gtg tac atc cgc agc acg gac ttt gac cgc acg      336
 Tyr Arg Arg Glu Glu Val Tyr Ile Arg Ser Thr Asp Phe Asp Arg Thr
             100                 105                 110

 ctg gag agt gcc cag gcc aac ctt gcc ggg ctg ttt ccc gag gct gct      384
 Leu Glu Ser Ala Gln Ala Asn Leu Ala Gly Leu Phe Pro Glu Ala Ala
         115                 120                 125

 cca ggg agc ccc gag gcc cgc tgg agg ccg atc ccg gtg cac acg gtg      432
 Pro Gly Ser Pro Glu Ala Arg Trp Arg Pro Ile Pro Val His Thr Val
     130                 135                 140

 ccc gtg gct gag gat aag ctg ctg agg ttc ccc atg cgc agc tgt ccc      480
 Pro Val Ala Glu Asp Lys Leu Leu Arg Phe Pro Met Arg Ser Cys Pro
 145                 150                 155                 160

 cga tac cac gag ctg ctg cgg gag gcc acc gag gcc gcc gag tac cag      528
 Arg Tyr His Glu Leu Leu Arg Glu Ala Thr Glu Ala Ala Glu Tyr Gln
                 165                 170                 175

 gag gcc ctg gag ggc tgg acg ggc ttc ctg agt cgc ctg gag aac ttc      576
 Glu Ala Leu Glu Gly Trp Thr Gly Phe Leu Ser Arg Leu Glu Asn Phe
             180                 185                 190

 acg gga ctg tcg ctg gtt gga gag cca ctg cgc agg gca tgg aag gtt      624
 Thr Gly Leu Ser Leu Val Gly Glu Pro Leu Arg Arg Ala Trp Lys Val
         195                 200                 205

 ctg gac acc ctc atg tgc cag caa gcc cac ggt ctt cca cta cca gcc      672
 Leu Asp Thr Leu Met Cys Gln Gln Ala His Gly Leu Pro Leu Pro Ala
     210                 215                 220

 tgg gcc tcc cca gat gtc ctg cgg act ctt gcc cag atc tcg gct ttg      720
 Trp Ala Ser Pro Asp Val Leu Arg Thr Leu Ala Gln Ile Ser Ala Leu
 225                 230                 235                 240

 gat att gga gcc cac gtg ggc cca ccc cgg gca gca gag aag gcc cag      768
 Asp Ile Gly Ala His Val Gly Pro Pro Arg Ala Ala Glu Lys Ala Gln
                 245                 250                 255

 ctg aca ggg ggg atc ctg ctg aat gct atc ctt gca aac ttc tcc cgg      816
 Leu Thr Gly Gly Ile Leu Leu Asn Ala Ile Leu Ala Asn Phe Ser Arg
             260                 265                 270

 gtc cag cgc ctg ggg ctg ccc ctc aag atg gtc atg tac tca gct cat      864
 Val Gln Arg Leu Gly Leu Pro Leu Lys Met Val Met Tyr Ser Ala His
         275                 280                 285

 gac agc acc ctg ctg gcc ctc cag ggg gcc ctg ggc ctc tat gat gga      912
 Asp Ser Thr Leu Leu Ala Leu Gln Gly Ala Leu Gly Leu Tyr Asp Gly
     290                 295                 300

 cac acc ccg cca tat gct gcc tgc ctc ggc ttt gag ttc cgg aag cac      960
 His Thr Pro Pro Tyr Ala Ala Cys Leu Gly Phe Glu Phe Arg Lys His
 305                 310                 315                 320

 ctg ggg aat ccc gcc aaa gat gga ggg aat gtc acc gtc tcc ctc ttc     1008
 Leu Gly Asn Pro Ala Lys Asp Gly Gly Asn Val Thr Val Ser Leu Phe
                 325                 330                 335

 tac cgc aat gac tcc gcc cac ctg ccc ctg cct ctc agc ctc ccc ggg     1056
 Tyr Arg Asn Asp Ser Ala His Leu Pro Leu Pro Leu Ser Leu Pro Gly
             340                 345                 350

 tgc ccg gcc ccc tgt cca cta ggc cgc ttc tac cag ctg act gcc ccg     1104
 Cys Pro Ala Pro Cys Pro Leu Gly Arg Phe Tyr Gln Leu Thr Ala Pro
         355                 360                 365

 gcc cgg cct ccc gcc cat ggg gtc tcc tgc cat ggc ccc tat gag gct     1152
 Ala Arg Pro Pro Ala His Gly Val Ser Cys His Gly Pro Tyr Glu Ala
     370                 375                 380

 gcc atc ccc cca gct cca gtg gtg ccc ctg ctg gcc gga gct gta gct     1200
 Ala Ile Pro Pro Ala Pro Val Val Pro Leu Leu Ala Gly Ala Val Ala
 385                 390                 395                 400

 gtg ctg gtg gca ctc agc ttg ggg ctg ggc ctg ctg gcc tgg aga cca     1248
 Val Leu Val Ala Leu Ser Leu Gly Leu Gly Leu Leu Ala Trp Arg Pro
                 405                 410                 415

 ggg tgc ctg cgg gcc ttg ggg ggc ccc gtg tga gccagaaa ccagggcttc     1299
 Gly Cys Leu Arg Ala Leu Gly Gly Pro Val 
             420                 425

 cctaccccca gctgacactg gaccccaaca tgtatgctca gtagctgc                1347




      <210> 275
      <211> 1153
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(1052)

      <400> 275
 ggcaccacca ctgacctggg acagtgaatc tgagcatcgc tacagccttt gca   atg      56
                                                              Met
                                                                1

 ctc tcc ctg ggg acc aag gct gac act cac gat gaa atc ctg gag ggc      104
 Leu Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly
               5                  10                  15

 ctg aat ttc aac ctc acg gag att ccg gag gct cag atc cat gaa ggc      152
 Leu Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly
          20                  25                  30

 ttc cag gaa ctc ctc cgt acc ctc aac cag cca gac agc cag ctc cag      200
 Phe Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln
      35                  40                  45

 ctg acc acc ggc aat ggc ctg ttc ctc agc gag ggc ctg aag cta gtg      248
 Leu Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val
  50                  55                  60                  65

 gat aag ttt ttg gag gat gtt aaa aag ttg tac cac tca gaa gcc ttc      296
 Asp Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe
                  70                  75                  80

 act gtc aac ttc ggg gac acc gaa gag gcc aag aaa cag atc aac gat      344
 Thr Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp
              85                  90                  95

 tac gtg gag aag ggt act caa ggg aaa att gtg gat ttg gtc aag gag      392
 Tyr Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu
         100                 105                 110

 ctt gac aga gac aca gtt ttt gct ctg gtg aat tac atc ttc ttt aaa      440
 Leu Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys
     115                 120                 125

 ggc aaa tgg gag aga ccc ttt gaa gtc aag gac acc gag gaa gag gac      488
 Gly Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp
 130                 135                 140                 145

 ttc cac gtg gac cag gtg acc acc gtg aag gtg cct atg atg aag cgt      536
 Phe His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg
                 150                 155                 160

 tta ggc atg ttt aac atc cag cac tgt aag aag ctg tcc agc tgg gtg      584
 Leu Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val
             165                 170                 175

 ctg ctg atg aaa tac ctg ggc aat gcc acc gcc atc ttc ttc ctg cct      632
 Leu Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro
         180                 185                 190

 gat gag ggg aaa cta cag cac ctg gaa aat gaa ctc acc cac gat atc      680
 Asp Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile
     195                 200                 205

 atc acc aag ttc ctg gaa aat gaa gac aga agg tct gcc agc tta cat      728
 Ile Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His
 210                 215                 220                 225

 tta ccc aaa ctg tcc att act gga acc tat gat ctg aag agc gtc ctg      776
 Leu Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu
                 230                 235                 240

 ggt caa ctg ggc atc act aag gtc ttc agc aat ggg gct gac ctc tcc      824
 Gly Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser
             245                 250                 255

 ggg gtc aca gag gag gca ccc ctg aag ctc tcc aag gcc gtg cat aag      872
 Gly Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys
         260                 265                 270

 gct gtg ctg acc atc gac gag aaa ggg act gaa gct gct ggg gcc atg      920
 Ala Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met
     275                 280                 285

 ttt tta gag gcc ata ccc atg tct atc ccc ccc gag gtc aag ttc aac      968
 Phe Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn
 290                 295                 300                 305

 aaa ccc ttt gtc ttc tta atg att gaa caa aat acc aag tct ccc ctc     1016
 Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu
                 310                 315                 320

 ttc atg gga aaa gtg gtg aat ccc acc caa aaa taa ctgc ctctcgctcc     1066
 Phe Met Gly Lys Val Val Asn Pro Thr Gln Lys 
             325                 330

 tcaacccctc ccctccatcc ctggccccct ccctggatga cattaaagaa gggttgagct   1126

 ggtccctgcc tgcaaaaaaa aaaaaaa                                       1153




      <210> 276
      <211> 2385
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1082)..(2284)

      <400> 276
 ctggagatac cggggctgaa gcatatggag tcacccagcc cggtgtccat gtccttggat     60

 aggccattgc ttttagagct ggagatgggt gcacaggctg atgtggctag ggatggccac    120

 tttcctggga ctttgatggt agatgtccga aggtcaatct cttttttatg aatattcttc    180

 atataatcac ctaagcttga ataataggtg agcacgccat cggaacacag ggtgacgtat    240

 ttctttttcc atgtcttcag ccattttcca cttcgcttta agagcatgcc ctgtttaatg    300

 gggatggctc tgccgctccc gatggtgtca gcatgattct ccggggcttt cctctctttg    360

 tctgggtcac tccctttctc agatgtaaac aggttggacc agcgcatgga ccgcttgcaa    420

 acgggggtgg gtgtgttggc agtgggagga acactgaact gagggtcctc ctggctggtg    480

 ctgggagtcg gtggaatgga ggaggaatag ttatttaaac tcccacctcc atttcttttc    540

 ttcataatgt gcacggtgga aaccgcaaat gagtgtaact gttcatcagg tatgctcaaa    600

 gatctatctg catctctttg tgtgatatga tgaggtatct ccaaggtcac agatattatt    660

 gtcattgtaa gataatgctg gatggctgtg ctgtcatcaa ggaatattgt cgaacacgag    720

 ctgtattgtt gactgaaacg ctcagtagat acatggtttg tacagttgct tcttcttatt    780

 tctacaacat ctgtttgaga gttcctctgg aatattgtgc ttgcctctgg attggcagaa    840

 gagttaaact ccaaagcatc tgtttgagag ttcctctgga atattgtgct tgcctctgga    900

 ttggcagaaa ggttaaactc caaagcttca ggcatctccc ggtcacgaac ctggtgcatg    960

 tggaggtcct caccaacttc aacagtcacc tcagcaggct gtacagcagc agccatgggc   1020

 gctcctgcca tcctgtcctc agcttcaggc accaccactg acctgggaca gtgaatcgac   1080

 a    atg ccg tct tct gtc tcg tgg ggc atc ctc ctg ctg gca ggc ctg    1126
      Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu
        1               5                  10                  15

 tgc tgc ctg gtc cct gtc tcc ctg gct gag gat ccc cag gga gat gct     1174
 Cys Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala
                  20                  25                  30

 gcc cag aag aca gat aca tcc cac cat gat cag gat cac cca acc ttc     1222
 Ala Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe
              35                  40                  45

 aac aag atc acc ccc aac ctg gct gag ttc gcc ttc agc cta tac cgc     1270
 Asn Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg
          50                  55                  60

 cag ctg gca cac cag tcc aac agc acc aat atc ttc ttc tcc cca gtg     1318
 Gln Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val
      65                  70                  75

 agc atc gct aca gcc ttt gca atg ctc tcc ctg ggg acc aag gct gac     1366
 Ser Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp
  80                  85                  90                  95

 act cac gat gaa atc ctg gag ggc ctg aat ttc aac ctc acg gag att     1414
 Thr His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile
                 100                 105                 110

 ccg gag gct cag atc cat gaa ggc ttc cag gaa ctc ctc cgt acc ctc     1462
 Pro Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu
             115                 120                 125

 aac cag cca gac agc cag ctc cag ctg acc acc ggc aat ggc ctg ttc     1510
 Asn Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe
         130                 135                 140

 ctc agc gag ggc ctg aag cta gtg gat aag ttt ttg gag gat gtt aaa     1558
 Leu Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys
     145                 150                 155

 aag ttg tac cac tca gaa gcc ttc act gtc aac ttc ggg gac acc gaa     1606
 Lys Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu
 160                 165                 170                 175

 gag gcc aag aaa cag atc aac gat tac gtg gag aag ggt act caa ggg     1654
 Glu Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly
                 180                 185                 190

 aat tac atc ttc ttt aaa ggc aaa tgg gag aga ccc ttt gaa gtc aag     1702
 Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val Lys
             195                 200                 205

 gac acc gag gaa gag gac ttc cac gtg gac cag gtg acc acc gtg aag     1750
 Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val Lys
         210                 215                 220

 gtg cct atg atg aag cgt tta ggc atg ttt aac atc cag cac tgt aag     1798
 Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys Lys
     225                 230                 235

 aag ctg tcc agc tgg gtg ctg ctg atg aaa tac ctg ggc aat gcc acc     1846
 Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala Thr
 240                 245                 250                 255

 gcc atc ttc ttc ctg cct gat gag ggg aaa cta cag cac ctg gaa aat     1894
 Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu Asn
                 260                 265                 270

 gaa ctc acc cac gat atc atc acc aag ttc ctg gaa aat gaa gac aga     1942
 Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp Arg
             275                 280                 285

 agg tct gcc agc tta cat tta ccc aaa ctg tcc att act gga acc tat     1990
 Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr Tyr
         290                 295                 300

 gat ctg aag agc gtc ctg ggt caa ctg ggc atc act aag gtc ttc agc     2038
 Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe Ser
     305                 310                 315

 aat ggg gct gac ctc tcc ggg gtc aca gag gag gca ccc ctg aag ctc     2086
 Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys Leu
 320                 325                 330                 335

 tcc aag gcc gtg cat aag gct gtg ctg acc atc gac gag aaa ggg act     2134
 Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr
                 340                 345                 350

 gaa gct gct ggg gcc atg ttt tta gag gcc ata ccc atg tct atc ccc     2182
 Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro
             355                 360                 365

 ccc gag gtc aag ttc aac aaa ccc ttt gtc ttc tta atg att gaa caa     2230
 Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln
         370                 375                 380

 aat acc aag tct ccc ctc ttc atg gga aaa gtg gtg aat ccc acc caa     2278
 Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln
     385                 390                 395

 aaa taa ctgcctctcg ctcctcaacc cctcccctcc atccctggcc ccctccctgg      2334
 Lys 
 400

 atgacattaa agaagggttg agctggtccc tgcctgcaaa aaaaaaaaaa a            2385




      <210> 277
      <211> 2385
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1082)..(2284)

      <400> 277
 ctggagatac cggggctgaa gcatatggag tcacccagcc cggtgtccat gtccttggat     60

 aggccattgc ttttagagct ggagatgggt gcacaggctg atgtggctag ggatggccac    120

 tttcctggga ctttgatggt agatgtccga aggtcaatct cttttttatg aatattcttc    180

 atataatcac ctaagcttga ataataggtg agcacgccat cggaacacag ggtgacgtat    240

 ttctttttcc atgtcttcag ccattttcca cttcgcttta agagcatgcc ctgtttaatg    300

 gggatggctc tgccgctccc gatggtgtca gcatgattct ccggggcttt cctctctttg    360

 tctgggtcac tccctttctc agatgtaaac aggttggacc agcgcatgga ccgcttgcaa    420

 acgggggtgg gtgtgttggc agtgggagga acactgaact gagggtcctc ctggctggtg    480

 ctgggagtcg gtggaatgga ggaggaatag ttatttaaac tcccacctcc atttcttttc    540

 ttcataatgt gcacggtgga aaccgcaaat gagtgtaact gttcatcagg tatgctcaaa    600

 gatctatctg catctctttg tgtgatatga tgaggtatct ccaaggtcac agatattatt    660

 gtcattgtaa gataatgctg gatggctgtg ctgtcatcaa ggaatattgt cgaacacgag    720

 ctgtattgtt gactgaaacg ctcagtagat acatggtttg tacagttgct tcttcttatt    780

 tctacaacat ctgtttgaga gttcctctgg aatattgtgc ttgcctctgg attggcagaa    840

 gagttaaact ccaaagcatc tgtttgagag ttcctctgga atattgtgct tgcctctgga    900

 ttggcagaaa ggttaaactc caaagcttca ggcatctccc ggtcacgaac ctggtgcatg    960

 tggaggtcct caccaacttc aacagtcacc tcagcaggct gtacagcagc agccatgggc   1020

 gctcctgcca tcctgtcctc agcttcaggc accaccactg acctgggaca gtgaatcgac   1080

 a    atg ccg tct tct gtc tcg tgg ggc atc ctc ctg ctg gca ggc ctg    1126
      Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu
        1               5                  10                  15

 tgc tgc ctg gtc cct gtc tcc ctg gct gag gat ccc cag gga gat gct     1174
 Cys Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala
                  20                  25                  30

 gcc cag aag aca gat aca tcc cac cat gat cag gat cac cca acc ttc     1222
 Ala Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe
              35                  40                  45

 aac aag atc acc ccc aac ctg gct gag ttc gcc ttc agc cta tac cgc     1270
 Asn Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg
          50                  55                  60

 cag ctg gca cac cag tcc aac agc acc aat atc ttc ttc tcc cca gtg     1318
 Gln Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val
      65                  70                  75

 agc atc gct aca gcc ttt gca atg ctc tcc ctg ggg acc aag gct gac     1366
 Ser Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp
  80                  85                  90                  95

 act cac gat gaa atc ctg gag ggc ctg aat ttc aac ctc acg gag att     1414
 Thr His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile
                 100                 105                 110

 ccg gag gct cag atc cat gaa ggc ttc cag gaa ctc ctc cgt acc ctc     1462
 Pro Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu
             115                 120                 125

 aac cag cca gac agc cag ctc cag ctg acc acc ggc aat ggc ctg ttc     1510
 Asn Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe
         130                 135                 140

 ctc agc gag ggc ctg aag cta gtg gat aag ttt ttg gag gat gtt acc     1558
 Leu Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Thr
     145                 150                 155

 aag aaa cag atc aac gat tac gtg gag aag ggt act caa ggg aaa att     1606
 Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys Ile
 160                 165                 170                 175

 gtg gat ttg gtc aag gag ctt gac aga gac aca gtt ttt gct ctg gtg     1654
 Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu Val
                 180                 185                 190

 aat tac atc ttc ttt aaa ggc aaa tgg gag aga ccc ttt gaa gtc aag     1702
 Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val Lys
             195                 200                 205

 gac acc gag gaa gag gac ttc cac gtg gac cag gtg acc acc gtg aag     1750
 Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val Lys
         210                 215                 220

 gtg cct atg atg aag cgt tta ggc atg ttt aac atc cag cac tgt aag     1798
 Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys Lys
     225                 230                 235

 aag ctg tcc agc tgg gtg ctg ctg atg aaa tac ctg ggc aat gcc acc     1846
 Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala Thr
 240                 245                 250                 255

 gcc atc ttc ttc ctg cct gat gag ggg aaa cta cag cac ctg gaa aat     1894
 Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu Asn
                 260                 265                 270

 gaa ctc acc cac gat atc atc acc aag ttc ctg gaa aat gaa gac aga     1942
 Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp Arg
             275                 280                 285

 agg tct gcc agc tta cat tta ccc aaa ctg tcc att act gga acc tat     1990
 Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr Tyr
         290                 295                 300

 gat ctg aag agc gtc ctg ggt caa ctg ggc atc act aag gtc ttc agc     2038
 Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe Ser
     305                 310                 315

 aat ggg gct gac ctc tcc ggg gtc aca gag gag gca ccc ctg aag ctc     2086
 Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys Leu
 320                 325                 330                 335

 tcc aag gcc gtg cat aag gct gtg ctg acc atc gac gag aaa ggg act     2134
 Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr
                 340                 345                 350

 gaa gct gct ggg gcc atg ttt tta gag gcc ata ccc atg tct atc ccc     2182
 Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro
             355                 360                 365

 ccc gag gtc aag ttc aac aaa ccc ttt gtc ttc tta atg att gaa caa     2230
 Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln
         370                 375                 380

 aat acc aag tct ccc ctc ttc atg gga aaa gtg gtg aat ccc acc caa     2278
 Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln
     385                 390                 395

 aaa taa ctgcctctcg ctcctcaacc cctcccctcc atccctggcc ccctccctgg      2334
 Lys 
 400

 atgacattaa agaagggttg agctggtccc tgcctgcaaa aaaaaaaaaa a            2385




      <210> 278
      <211> 2385
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1082)..(2284)

      <400> 278
 ctggagatac cggggctgaa gcatatggag tcacccagcc cggtgtccat gtccttggat     60

 aggccattgc ttttagagct ggagatgggt gcacaggctg atgtggctag ggatggccac    120

 tttcctggga ctttgatggt agatgtccga aggtcaatct cttttttatg aatattcttc    180

 atataatcac ctaagcttga ataataggtg agcacgccat cggaacacag ggtgacgtat    240

 ttctttttcc atgtcttcag ccattttcca cttcgcttta agagcatgcc ctgtttaatg    300

 gggatggctc tgccgctccc gatggtgtca gcatgattct ccggggcttt cctctctttg    360

 tctgggtcac tccctttctc agatgtaaac aggttggacc agcgcatgga ccgcttgcaa    420

 acgggggtgg gtgtgttggc agtgggagga acactgaact gagggtcctc ctggctggtg    480

 ctgggagtcg gtggaatgga ggaggaatag ttatttaaac tcccacctcc atttcttttc    540

 ttcataatgt gcacggtgga aaccgcaaat gagtgtaact gttcatcagg tatgctcaaa    600

 gatctatctg catctctttg tgtgatatga tgaggtatct ccaaggtcac agatattatt    660

 gtcattgtaa gataatgctg gatggctgtg ctgtcatcaa ggaatattgt cgaacacgag    720

 ctgtattgtt gactgaaacg ctcagtagat acatggtttg tacagttgct tcttcttatt    780

 tctacaacat ctgtttgaga gttcctctgg aatattgtgc ttgcctctgg attggcagaa    840

 gagttaaact ccaaagcatc tgtttgagag ttcctctgga atattgtgct tgcctctgga    900

 ttggcagaaa ggttaaactc caaagcttca ggcatctccc ggtcacgaac ctggtgcatg    960

 tggaggtcct caccaacttc aacagtcacc tcagcaggct gtacagcagc agccatgggc   1020

 gctcctgcca tcctgtcctc agcttcaggc accaccactg acctgggaca gtgaatcgac   1080

 a    atg ccg tct tct gtc tcg tgg ggc atc ctc ctg ctg gca ggc ctg    1126
      Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu
        1               5                  10                  15

 tgc tgc ctg gtc cct gtc tcc ctg gct gag gat ccc cag gga gat gct     1174
 Cys Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala
                  20                  25                  30

 gcc cag aag aca gat aca tcc cac cat gat cag gat cac cca acc ttc     1222
 Ala Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe
              35                  40                  45

 aac aag atc acc ccc aac ctg gct gag ttc gcc ttc agc cta tac cgc     1270
 Asn Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg
          50                  55                  60

 cag ctg gca cac cag tcc aac agc acc aat atc ttc ttc tcc cca gtg     1318
 Gln Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val
      65                  70                  75

 agc atc gct aca gcc ttt gca atg ctc tcc ctg ggg acc aag gct gac     1366
 Ser Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp
  80                  85                  90                  95

 act cac gat gaa atc ctg gag ggc ctg aat ttc aac ctc acg gag att     1414
 Thr His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile
                 100                 105                 110

 ccg gag gct cag atc cat gaa ggc ttc cag gaa ctc ctc cgt acc ctc     1462
 Pro Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu
             115                 120                 125

 aac cag cca gac agc cag ctc cag ctg acc acc ggc aat ggc ctg ttc     1510
 Asn Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe
         130                 135                 140

 ctc agc gag ggc ctg aag cta gtg gat aag ttt ttg gag gat gtt aaa     1558
 Leu Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys
     145                 150                 155

 aag ttg tac cac tca gaa gcc ttc act gtc aac ttc ggg gac acc gaa     1606
 Lys Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu
 160                 165                 170                 175

 gag gcc aag aaa cag atc aac gat tac gtg gag aag ggt act caa ggg     1654
 Glu Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly
                 180                 185                 190

 aaa att gtg gat ttg gtc aag gag ctt gac aga gac aca gtt ttt gct     1702
 Lys Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala
             195                 200                 205

 ctg gtg aat tac atc ttc ttt aaa ggc aaa tgg gag aga ccc ttt gaa     1750
 Leu Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu
         210                 215                 220

 gtc aag gac acc gag gaa gag gac ttc cac gtg gac cag gtg acc acc     1798
 Val Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr
     225                 230                 235

 gtg aag gtg cct atg atg aag cgt tta ggc atg ttt aac atc cag cac     1846
 Val Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His
 240                 245                 250                 255

 tgt aag aag ctg tcc agc tgg gtg ctg ctg atg aaa tac ctg ggc aat     1894
 Cys Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn
                 260                 265                 270

 gcc acc gcc atc ttc ttc ctg cct gat gag ggg aaa cta cag cac ctg     1942
 Ala Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu
             275                 280                 285

 gaa aat gaa ctc acc cac gat atc atc acc aag ttc ctg gga acc tat     1990
 Glu Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Gly Thr Tyr
         290                 295                 300

 gat ctg aag agc gtc ctg ggt caa ctg ggc atc act aag gtc ttc agc     2038
 Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe Ser
     305                 310                 315

 aat ggg gct gac ctc tcc ggg gtc aca gag gag gca ccc ctg aag ctc     2086
 Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys Leu
 320                 325                 330                 335

 tcc aag gcc gtg cat aag gct gtg ctg acc atc gac gag aaa ggg act     2134
 Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr
                 340                 345                 350

 gaa gct gct ggg gcc atg ttt tta gag gcc ata ccc atg tct atc ccc     2182
 Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro
             355                 360                 365

 ccc gag gtc aag ttc aac aaa ccc ttt gtc ttc tta atg att gaa caa     2230
 Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln
         370                 375                 380

 aat acc aag tct ccc ctc ttc atg gga aaa gtg gtg aat ccc acc caa     2278
 Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln
     385                 390                 395

 aaa taa ctgcctctcg ctcctcaacc cctcccctcc atccctggcc ccctccctgg      2334
 Lys 
 400

 atgacattaa agaagggttg agctggtccc tgcctgcaaa aaaaaaaaaa a            2385




      <210> 279
      <211> 1736
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (298)..(1314)

      <400> 279
 caacgccctg cctttctctg gctcagattc agaggaggag ttccactgcg gactgccgct     60

 tcttcaccct ctgggcttcg gaagcagcac ctctggctcc cctgcaccca gtcctcagtc    120

 ttgtggccct ggtctgcccc tttatcacat gtcttgagca ccctctcagc acacagcacc    180

 gttctgagcg ctgaggtgcg accatgcata gaagagacaa gaatccctgg ttccgcatgg    240

 cttccctcaa cacctacgtt tccaggccat ggcttgggtt cagaagaatc accctcc       297                                                                 
 atg cga ggg gaa gaa tgc ccc ctg gac ctg gac ctg gac ctg gac ctg      345
 Met Arg Gly Glu Glu Cys Pro Leu Asp Leu Asp Leu Asp Leu Asp Leu
   1               5                  10                  15

 gac ctg gac ctg gac ctg gcc cag gcc aca ggc tgg gat tct gca gag      393
 Asp Leu Asp Leu Asp Leu Ala Gln Ala Thr Gly Trp Asp Ser Ala Glu
              20                  25                  30

 gct cta act cgg gcc act cag ctg tcg gcg gcc cgg agg aat ctg ctt      441
 Ala Leu Thr Arg Ala Thr Gln Leu Ser Ala Ala Arg Arg Asn Leu Leu
          35                  40                  45

 tgt tat ggc ttt cag gat cta aaa gag agg aga agc ctt aca cat cga      489
 Cys Tyr Gly Phe Gln Asp Leu Lys Glu Arg Arg Ser Leu Thr His Arg
      50                  55                  60

 atc agc act tca gaa aca gga act aac agt aag cag cat aga gat tta      537
 Ile Ser Thr Ser Glu Thr Gly Thr Asn Ser Lys Gln His Arg Asp Leu
  65                  70                  75                  80

 ctt aca agg gca gaa agt gcc ctg acg cag gct tac agt tgg cta ctc      585
 Leu Thr Arg Ala Glu Ser Ala Leu Thr Gln Ala Tyr Ser Trp Leu Leu
                  85                  90                  95

 aga gcc caa ata tcg atc gaa agt ggg gag ggc ggt aga ggg gcc gct      633
 Arg Ala Gln Ile Ser Ile Glu Ser Gly Glu Gly Gly Arg Gly Ala Ala
             100                 105                 110

 gct aac cca tca gga gag aag ctg gac gac tgc tgc cga gag gat gct      681
 Ala Asn Pro Ser Gly Glu Lys Leu Asp Asp Cys Cys Arg Glu Asp Ala
         115                 120                 125

 ggc tac atg gta gaa gcc caa agg ctc tcc aag agg aat atg gca ggg      729
 Gly Tyr Met Val Glu Ala Gln Arg Leu Ser Lys Arg Asn Met Ala Gly
     130                 135                 140

 tct gct tcc tca tct ctt tca agg gag ggt gat tct tct gaa ccc aag      777
 Ser Ala Ser Ser Ser Leu Ser Arg Glu Gly Asp Ser Ser Glu Pro Lys
 145                 150                 155                 160

 cca tgg cct gga aac gta ggt gtt gag gga agc cat gcg gaa cca ggg      825
 Pro Trp Pro Gly Asn Val Gly Val Glu Gly Ser His Ala Glu Pro Gly
                 165                 170                 175

 att ctt gtc tct tct atg cat ggt cgc acc tca gcg ctc aga acg gtg      873
 Ile Leu Val Ser Ser Met His Gly Arg Thr Ser Ala Leu Arg Thr Val
             180                 185                 190

 ctg tgt gct gag agg gtg ctc aag aca tgt gat aaa ggg gca gac cag      921
 Leu Cys Ala Glu Arg Val Leu Lys Thr Cys Asp Lys Gly Ala Asp Gln
         195                 200                 205

 ggc cac aag act gag gac tgg gtg cag ggg agc cag agg tgc tgc ttc      969
 Gly His Lys Thr Glu Asp Trp Val Gln Gly Ser Gln Arg Cys Cys Phe
     210                 215                 220

 cga agc cca gag ggt gaa gaa gcg gca gtc cgc agt gga act cct cct     1017
 Arg Ser Pro Glu Gly Glu Glu Ala Ala Val Arg Ser Gly Thr Pro Pro
 225                 230                 235                 240

 ctg aat ctg agc cag aga aag gca ggg cgt tgt aac cag cca gct tgg     1065
 Leu Asn Leu Ser Gln Arg Lys Ala Gly Arg Cys Asn Gln Pro Ala Trp
                 245                 250                 255

 agc agc atg cct cta acc gag gaa cag gaa ggg ctg gct ggt ccc aaa     1113
 Ser Ser Met Pro Leu Thr Glu Glu Gln Glu Gly Leu Ala Gly Pro Lys
             260                 265                 270

 tgg acc cag gca gat att aag ctc cta ccc ttc ata tcc aag aat cga     1161
 Trp Thr Gln Ala Asp Ile Lys Leu Leu Pro Phe Ile Ser Lys Asn Arg
         275                 280                 285

 aag gaa gta gac cta aca ctt ggt cag atg ctt tgg att gaa atc atg     1209
 Lys Glu Val Asp Leu Thr Leu Gly Gln Met Leu Trp Ile Glu Ile Met
     290                 295                 300

 agg tct ttc gat aca agc agc aat ctg gaa gtg aca gac aca gat ttc     1257
 Arg Ser Phe Asp Thr Ser Ser Asn Leu Glu Val Thr Asp Thr Asp Phe
 305                 310                 315                 320

 ttc ctg gac acc atg gac aaa gca cag gca ggt ccc gag ttt ggc caa     1305
 Phe Leu Asp Thr Met Asp Lys Ala Gln Ala Gly Pro Glu Phe Gly Gln
                 325                 330                 335

 aga acg tga ctggctg atggacagga ctaaactacc ccttcgccca ctttcttcct     1361
 Arg Thr 


 tttgtccttt gaacacaggc agccctttct ttctgactat acttatgcta aatccttgtt   1421

 tgtctgccca tttcctcaat gcagtgccca ctgagatggg gatataaagc tgtctgcaca   1481

 aggtcacaaa gcacagtagc atcagagctg gagtcagggc tctgctcttg tgatttgcaa   1541

 tcctgttctc ttgccaaggg gccaagctgc ttccagtacc caaagggaac atccaatagc   1601

 ttattttgat cacagagagt tgagtcaaga aggaactgat cctatgctga caaactgaat   1661

 gaatgtgaac tgctgccact tccgcacaat acatcaggac gaggctccat gctactctgt   1721

 cagctccacc actgc                                                    1736




      <210> 280
      <211> 3172
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(2495)

      <400> 280
 gctctgctga tggacatagg cccagaatca ttaactgatt tatttgggcc   atg tca      56
                                                          Met Ser
                                                            1

 ctg gtg gca tta tta aaa gac tct gcc aac atc ctg cct tta tgg aaa      104
 Leu Val Ala Leu Leu Lys Asp Ser Ala Asn Ile Leu Pro Leu Trp Lys
           5                  10                  15

 aac caa gtg gcc ttg gaa gag gct aag ata aag ttt caa act tgg gct      152
 Asn Gln Val Ala Leu Glu Glu Ala Lys Ile Lys Phe Gln Thr Trp Ala
      20                  25                  30

 cca cag aag tgg aac tta agg ctg ggg cta gta cca gga cct tca tgt      200
 Pro Gln Lys Trp Asn Leu Arg Leu Gly Leu Val Pro Gly Pro Ser Cys
  35                  40                  45                  50

 atc agg tta gag att ttg atg ctt ttg gtg att ttt gtg cca agc atg      248
 Ile Arg Leu Glu Ile Leu Met Leu Leu Val Ile Phe Val Pro Ser Met
                  55                  60                  65

 tac tgt cac ctg gga tca atc tat tac tct ttc tat gaa ata att att      296
 Tyr Cys His Leu Gly Ser Ile Tyr Tyr Ser Phe Tyr Glu Ile Ile Ile
              70                  75                  80

 cca aag agg ctg aca gtc cag gga gga gat agc cca gtg gaa gga ctg      344
 Pro Lys Arg Leu Thr Val Gln Gly Gly Asp Ser Pro Val Glu Gly Leu
          85                  90                  95

 tcc tac ttg tta ctt atg caa ggc cag aag cac ctg gtt cat ctg aag      392
 Ser Tyr Leu Leu Leu Met Gln Gly Gln Lys His Leu Val His Leu Lys
     100                 105                 110

 gtg aag aga aac cat ttt gtg aat aac ttt cca gtc tac agt tac cac      440
 Val Lys Arg Asn His Phe Val Asn Asn Phe Pro Val Tyr Ser Tyr His
 115                 120                 125                 130

 aat ggc ctc ctg ggg caa gaa tcg cct ttc atc tca cat gac tgc cac      488
 Asn Gly Leu Leu Gly Gln Glu Ser Pro Phe Ile Ser His Asp Cys His
                 135                 140                 145

 tat gaa ggc tac ata gaa gga gtg tca ggt tct ttt gtt tct gtc aac      536
 Tyr Glu Gly Tyr Ile Glu Gly Val Ser Gly Ser Phe Val Ser Val Asn
             150                 155                 160

 atc tgt gca ggt ctc agg ggc atc atc ctc ctg att aag gag gaa aaa      584
 Ile Cys Ala Gly Leu Arg Gly Ile Ile Leu Leu Ile Lys Glu Glu Lys
         165                 170                 175

 tct tac agc att gag ccc atg gac tct tca aga cgg ttt gaa cat gtg      632
 Ser Tyr Ser Ile Glu Pro Met Asp Ser Ser Arg Arg Phe Glu His Val
     180                 185                 190

 tta tac acc atg gca cat caa gcg aga gtc tcc tgt ggt gtc act agc      680
 Leu Tyr Thr Met Ala His Gln Ala Arg Val Ser Cys Gly Val Thr Ser
 195                 200                 205                 210

 tgg caa caa ggg agc agg aag cct cat gat cta cag gca ctg tcc tac      728
 Trp Gln Gln Gly Ser Arg Lys Pro His Asp Leu Gln Ala Leu Ser Tyr
                 215                 220                 225

 ttg tgg tca cac aaa aag tac gtg gag atg ttt gtc gtg gtc aac aac      776
 Leu Trp Ser His Lys Lys Tyr Val Glu Met Phe Val Val Val Asn Asn
             230                 235                 240

 cag cgg ttc cag atg tgg ggc agt aac gtc aat gag acg gtc cag aca      824
 Gln Arg Phe Gln Met Trp Gly Ser Asn Val Asn Glu Thr Val Gln Thr
         245                 250                 255

 gta gtg gat gtc att gct ctg gcc aac agc ttc act agg gga ata aac      872
 Val Val Asp Val Ile Ala Leu Ala Asn Ser Phe Thr Arg Gly Ile Asn
     260                 265                 270

 aca gag gtg gtg ctg gct gga atg gag att tgg acc gag ggg gac cta      920
 Thr Glu Val Val Leu Ala Gly Met Glu Ile Trp Thr Glu Gly Asp Leu
 275                 280                 285                 290

 ata gat gtc aca gtg gac ttg caa atc aca ctc agg aat ttc aat cac      968
 Ile Asp Val Thr Val Asp Leu Gln Ile Thr Leu Arg Asn Phe Asn His
                 295                 300                 305

 tgg aga caa gag atg ctc ttc cat cgt gca aaa cac gat gtt gcc cac     1016
 Trp Arg Gln Glu Met Leu Phe His Arg Ala Lys His Asp Val Ala His
             310                 315                 320

 atg atc gtt ggg cat cac cct gga cag aat atg ggc cag gcc ttt ctc     1064
 Met Ile Val Gly His His Pro Gly Gln Asn Met Gly Gln Ala Phe Leu
         325                 330                 335

 agt ggt gcc tgc tca agc ggt ttt gcg gca gct gtt gaa tcc ttc cat     1112
 Ser Gly Ala Cys Ser Ser Gly Phe Ala Ala Ala Val Glu Ser Phe His
     340                 345                 350

 cat gaa gat gtg ctg ttg ttt gca gcc ctg atg gcc cat gag ctc ggg     1160
 His Glu Asp Val Leu Leu Phe Ala Ala Leu Met Ala His Glu Leu Gly
 355                 360                 365                 370

 cac aac ctg ggt att cag cac gac cac tcg gcc tgc ttt tgt aaa gat     1208
 His Asn Leu Gly Ile Gln His Asp His Ser Ala Cys Phe Cys Lys Asp
                 375                 380                 385

 aag cac ttt tgc ctc atg cat gaa aat atc aca aaa gaa agt ggc ttc     1256
 Lys His Phe Cys Leu Met His Glu Asn Ile Thr Lys Glu Ser Gly Phe
             390                 395                 400

 agc agc tgc agc tct gac tac ttc tac cag ttc ctt cga gaa cac aaa     1304
 Ser Ser Cys Ser Ser Asp Tyr Phe Tyr Gln Phe Leu Arg Glu His Lys
         405                 410                 415

 ggg gcc tgc cta ttt aac aag cca cgg ccc agg ggc cgc aag cgt agg     1352
 Gly Ala Cys Leu Phe Asn Lys Pro Arg Pro Arg Gly Arg Lys Arg Arg
     420                 425                 430

 gat tct gcc tgt gga aat ggt gtg gtg gag gac acg gag cag tgt gac     1400
 Asp Ser Ala Cys Gly Asn Gly Val Val Glu Asp Thr Glu Gln Cys Asp
 435                 440                 445                 450

 tgt ggt tct cta tgt cag cat cat gca tgc tgt gat gaa aac tgt ata     1448
 Cys Gly Ser Leu Cys Gln His His Ala Cys Cys Asp Glu Asn Cys Ile
                 455                 460                 465

 ctg aag gcg aaa gca gag tgc agt gat ggt cca tgt tgt cat aag tgt     1496
 Leu Lys Ala Lys Ala Glu Cys Ser Asp Gly Pro Cys Cys His Lys Cys
             470                 475                 480

 aaa ttt cac cgt aag gga tat cct tgc tgt cct tct agt cgt tcc tgt     1544
 Lys Phe His Arg Lys Gly Tyr Pro Cys Cys Pro Ser Ser Arg Ser Cys
         485                 490                 495

 gat ctc cca gaa ttt tgc aat ggt aca tct gca tta tgc ccc aac aac     1592
 Asp Leu Pro Glu Phe Cys Asn Gly Thr Ser Ala Leu Cys Pro Asn Asn
     500                 505                 510

 agg cat aag caa gat ggc tca aaa tgt cat aca att tac gag tgc ctt     1640
 Arg His Lys Gln Asp Gly Ser Lys Cys His Thr Ile Tyr Glu Cys Leu
 515                 520                 525                 530

 aaa gtt cat tgt atg gac cct aat aat cag tgc tta caa tta tat gga     1688
 Lys Val His Cys Met Asp Pro Asn Asn Gln Cys Leu Gln Leu Tyr Gly
                 535                 540                 545

 tat ggt gca aaa tca gcc tca caa gag tgt tac aat tca atg aac agc     1736
 Tyr Gly Ala Lys Ser Ala Ser Gln Glu Cys Tyr Asn Ser Met Asn Ser
             550                 555                 560

 aaa ggg gac caa ttt gga aac tgt ggc att tct acc agt cct ggg tca     1784
 Lys Gly Asp Gln Phe Gly Asn Cys Gly Ile Ser Thr Ser Pro Gly Ser
         565                 570                 575

 caa tat gtt cgg tgt tca gat ggt aat ata ttt tgt ggg aaa ctt ata     1832
 Gln Tyr Val Arg Cys Ser Asp Gly Asn Ile Phe Cys Gly Lys Leu Ile
     580                 585                 590

 tgt tca ggt att aca ggc tta cca aaa atc aat ctc caa cat aca atg     1880
 Cys Ser Gly Ile Thr Gly Leu Pro Lys Ile Asn Leu Gln His Thr Met
 595                 600                 605                 610

 att cag gtc cct cag gga gat ggc tca tgt tgg agc atg gat gcc tat     1928
 Ile Gln Val Pro Gln Gly Asp Gly Ser Cys Trp Ser Met Asp Ala Tyr
                 615                 620                 625

 atg agt act gac att cct gat gaa gga gat gtg cac aat ggc act tac     1976
 Met Ser Thr Asp Ile Pro Asp Glu Gly Asp Val His Asn Gly Thr Tyr
             630                 635                 640

 tgt gca cca aac aaa gtc tgc ctg aat tcc gcc tgc aca gat aaa acc     2024
 Cys Ala Pro Asn Lys Val Cys Leu Asn Ser Ala Cys Thr Asp Lys Thr
         645                 650                 655

 cca gtg att tct gcc tgc aac cca gaa aaa acg tgt aat ggg aag gga     2072
 Pro Val Ile Ser Ala Cys Asn Pro Glu Lys Thr Cys Asn Gly Lys Gly
     660                 665                 670

 gtt tgt aat gat tta ggg cac tgc cac tgt aat gaa ggg cat gcc ccc     2120
 Val Cys Asn Asp Leu Gly His Cys His Cys Asn Glu Gly His Ala Pro
 675                 680                 685                 690

 cct gac tgt gtt act gca gga agt gga ggt agt gtg gac agt ggc cct     2168
 Pro Asp Cys Val Thr Ala Gly Ser Gly Gly Ser Val Asp Ser Gly Pro
                 695                 700                 705

 cct ggt aag cta ggt ggg aca cct tca gga gaa ggt gaa aat cac aat     2216
 Pro Gly Lys Leu Gly Gly Thr Pro Ser Gly Glu Gly Glu Asn His Asn
             710                 715                 720

 atg act cat tcc aga cgt gaa gaa cat gct gta gac atg atg ata tta     2264
 Met Thr His Ser Arg Arg Glu Glu His Ala Val Asp Met Met Ile Leu
         725                 730                 735

 tca ttc att ata ctt ttt ata ata tta tta tta agt aca att att tgt     2312
 Ser Phe Ile Ile Leu Phe Ile Ile Leu Leu Leu Ser Thr Ile Ile Cys
     740                 745                 750

 atc tgc ttg ctt aaa aaa tca cca gag gct gcc ccg gca gaa gct cct     2360
 Ile Cys Leu Leu Lys Lys Ser Pro Glu Ala Ala Pro Ala Glu Ala Pro
 755                 760                 765                 770

 cca gca gtg gct cca cca ccg gcc cca gaa ata aag cca gaa gca gca     2408
 Pro Ala Val Ala Pro Pro Pro Ala Pro Glu Ile Lys Pro Glu Ala Ala
                 775                 780                 785

 gaa gtg gcc aca gaa gaa aaa gaa gag aag gag gaa gaa aaa gaa gag     2456
 Glu Val Ala Thr Glu Glu Lys Glu Glu Lys Glu Glu Glu Lys Glu Glu
             790                 795                 800

 gag gag gag gaa gaa gag gag gaa gaa tca gat tcc taa ggttagaaat      2505
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Ser Asp Ser 
         805                 810

 agggagatga agccaagtat atcaaactcc tcaagtactg agtgggaatg agatgtttgg   2565

 tgaagtagaa atagatagct ttagtggctc tgactcagat atactgatgt agaaggaagg   2625

 attctttcac ttttattatt tattttggta attaaattta cattaattta atatgttaaa   2685

 tattttagta ccttttgctt tttcacattt catttgaacc attaacatgc atctttggac   2745

 atcaatgtcc ttgtcttttt ggcccaattg ttttagtcac cagaaacttt ttcaggacat   2805

 gctatcttct atttgtttga catacagaat catatgtacc tgaatttatt actaactctg   2865

 ggattttcat tttaagtaac aactacctat tatgtgagga cagttgttta tgtgattggt   2925

 tgttctaact tgccctataa atgtgcattc atcaaaggag aagtttttaa atccaaaaac   2985

 aaataaaacc cgattcatat tagacaactc ttcaggttcc acatggtata gttactgagt   3045

 ccactttatt ctggggcact gtgggaggga ctatatcaaa gtagaagacc ctgattgccc   3105

 gtaggttaag aggtcagcat tgaggtcacc tgctttccaa atctggcaga tgtttaatat   3165

 gatatat                                                             3172




      <210> 281
      <211> 498
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(389)

      <400> 281
 ccttgaaaag ctggtacgcc tgcaggtacc ggtccggaat tcccgggtcg acccacgcgt     60

 ccggtctaaa tcactcatca ttggttaaag ccgagctcac agcagaataa gccacc        116                                                                 
 atg agg ctg tcg gtg tgt ctc ctg ctg ctc acg ctg gcc ctt tgc tgc      164
 Met Arg Leu Ser Val Cys Leu Leu Leu Leu Thr Leu Ala Leu Cys Cys
   1               5                  10                  15

 tac cgg gca aat gca gtg gtc tgc caa gct ctt ggt tct gaa atc aca      212
 Tyr Arg Ala Asn Ala Val Val Cys Gln Ala Leu Gly Ser Glu Ile Thr
              20                  25                  30

 ggc ttc tta tta gct gga aaa cct gtg ttc aag ttc caa ctt gcc aaa      260
 Gly Phe Leu Leu Ala Gly Lys Pro Val Phe Lys Phe Gln Leu Ala Lys
          35                  40                  45

 ttt aag gca cct ctg gaa gct gtt gca gcc aag atg gaa gtg aag aaa      308
 Phe Lys Ala Pro Leu Glu Ala Val Ala Ala Lys Met Glu Val Lys Lys
      50                  55                  60

 tgc gtg gat acg atg gcc tat gag aaa aga gtg cta att aca aaa aca      356
 Cys Val Asp Thr Met Ala Tyr Glu Lys Arg Val Leu Ile Thr Lys Thr
  65                  70                  75                  80

 ttg gga aaa ata gca gag aaa tgt gat cgc tga gatgtaaa aagtttttaa      407
 Leu Gly Lys Ile Ala Glu Lys Cys Asp Arg 
                  85                  90

 tgctagtttc caccatcttt caatgatacc ctgatcttca ctgcagaatg taaaggtttc    467

 aacgtcttgc tctaataaat cacttgccct g                                   498




      <210> 282
      <211> 2797
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (83)..(1672)

      <400> 282
 acccacgcgt ctggccgcgg gccgcctctg cggcagcgct agtcgccttc tccgaatcgg     60

 ctccgcacag ctaggagaaa ag atg ttc act gtg ctg acc cgc caa cca tgt     112
                          Met Phe Thr Val Leu Thr Arg Gln Pro Cys
                            1               5                  10

 gag caa gca ggc ctc aag gcc ctc tac cga act cca acc atc att gcc      160
 Glu Gln Ala Gly Leu Lys Ala Leu Tyr Arg Thr Pro Thr Ile Ile Ala
                  15                  20                  25

 ttg gtg gtc ttg ctt gtg agt att gtg gta ctt gtg agt atc act gtc      208
 Leu Val Val Leu Leu Val Ser Ile Val Val Leu Val Ser Ile Thr Val
              30                  35                  40

 atc cag atc cac aag caa gag gtc ctc cct cca gga ctg aag tat ggt      256
 Ile Gln Ile His Lys Gln Glu Val Leu Pro Pro Gly Leu Lys Tyr Gly
          45                  50                  55

 att gtg ctg gat gcc ggg tct tca aga acc aca gtc tac gtg tat caa      304
 Ile Val Leu Asp Ala Gly Ser Ser Arg Thr Thr Val Tyr Val Tyr Gln
      60                  65                  70

 tgg cca gca gaa aaa gag aat aat acc gga gtg gtc agt caa acc ttc      352
 Trp Pro Ala Glu Lys Glu Asn Asn Thr Gly Val Val Ser Gln Thr Phe
  75                  80                  85                  90

 aaa tgt agt gtg aaa ggc tct gga atc tcc agc tat gga aat aac ccc      400
 Lys Cys Ser Val Lys Gly Ser Gly Ile Ser Ser Tyr Gly Asn Asn Pro
                  95                 100                 105

 caa gat gtc ccc aga gcc ttt gag gag tgt atg caa aaa gtc aag ggg      448
 Gln Asp Val Pro Arg Ala Phe Glu Glu Cys Met Gln Lys Val Lys Gly
             110                 115                 120

 cag gtt cca tcc cac ctc cac gga tcc acc ccc att cac ctg gga gcc      496
 Gln Val Pro Ser His Leu His Gly Ser Thr Pro Ile His Leu Gly Ala
         125                 130                 135

 acg gct ggg atg cgc ttg ctg agg ttg caa aat gaa aca gca gct aat      544
 Thr Ala Gly Met Arg Leu Leu Arg Leu Gln Asn Glu Thr Ala Ala Asn
     140                 145                 150

 gaa gtc ctt gaa agc atc caa agc tac ttc aag tcc cag ccc ttt gac      592
 Glu Val Leu Glu Ser Ile Gln Ser Tyr Phe Lys Ser Gln Pro Phe Asp
 155                 160                 165                 170

 ttt agg ggt gct caa atc att tct ggg caa gaa gaa ggg gta tat gga      640
 Phe Arg Gly Ala Gln Ile Ile Ser Gly Gln Glu Glu Gly Val Tyr Gly
                 175                 180                 185

 tgg att aca gcc aac tat tta atg gga aat ttc ctg gag aag aac ctg      688
 Trp Ile Thr Ala Asn Tyr Leu Met Gly Asn Phe Leu Glu Lys Asn Leu
             190                 195                 200

 tgg cac atg tgg gtg cac ccg cat gga gtg gaa acc acg ggt gcc ctg      736
 Trp His Met Trp Val His Pro His Gly Val Glu Thr Thr Gly Ala Leu
         205                 210                 215

 gac tta ggt ggt gcc tcc acc caa ata tcc ttc gtg gca gga gag aag      784
 Asp Leu Gly Gly Ala Ser Thr Gln Ile Ser Phe Val Ala Gly Glu Lys
     220                 225                 230

 atg gat ctg aac acc agc gac atc atg cag gtg tcc ctg tat ggc tac      832
 Met Asp Leu Asn Thr Ser Asp Ile Met Gln Val Ser Leu Tyr Gly Tyr
 235                 240                 245                 250

 gta tac acg ctc tac aca cac agc ttc cag tgc tat ggc cgg aat gag      880
 Val Tyr Thr Leu Tyr Thr His Ser Phe Gln Cys Tyr Gly Arg Asn Glu
                 255                 260                 265

 gct gag aag aag ttt ctg gca atg ctc ctg cag aat tct cct acc aaa      928
 Ala Glu Lys Lys Phe Leu Ala Met Leu Leu Gln Asn Ser Pro Thr Lys
             270                 275                 280

 aac cat ctc acc aat ccc tgt tac cct cgg gat tat agc atc agc ttc      976
 Asn His Leu Thr Asn Pro Cys Tyr Pro Arg Asp Tyr Ser Ile Ser Phe
         285                 290                 295

 acc atg ggc cat gta ttt gat agc ctg tgc act gtg gac cag agg cca     1024
 Thr Met Gly His Val Phe Asp Ser Leu Cys Thr Val Asp Gln Arg Pro
     300                 305                 310

 gaa agt tat aac ccc aat gat gtc atc act ttt gaa gga act ggg gac     1072
 Glu Ser Tyr Asn Pro Asn Asp Val Ile Thr Phe Glu Gly Thr Gly Asp
 315                 320                 325                 330

 cca tct ctg tgt aag gag aag gtg gct tcc ata ttt gac ttc aaa gct     1120
 Pro Ser Leu Cys Lys Glu Lys Val Ala Ser Ile Phe Asp Phe Lys Ala
                 335                 340                 345

 tgc cat gat caa gaa acc tgt tct ttt gat ggg gtt tat cag cca aag     1168
 Cys His Asp Gln Glu Thr Cys Ser Phe Asp Gly Val Tyr Gln Pro Lys
             350                 355                 360

 att aaa ggg cca ttt gtg gct ttt gca gga ttc tac tac aca gcc agt     1216
 Ile Lys Gly Pro Phe Val Ala Phe Ala Gly Phe Tyr Tyr Thr Ala Ser
         365                 370                 375

 gct tta aat ctt tca ggt agc ttt tcc ctg gac acc ttc aac tcc agc     1264
 Ala Leu Asn Leu Ser Gly Ser Phe Ser Leu Asp Thr Phe Asn Ser Ser
     380                 385                 390

 acc tgg aat ttc tgc tca cag aat tgg agt cag ctc cca ctg ctg ctc     1312
 Thr Trp Asn Phe Cys Ser Gln Asn Trp Ser Gln Leu Pro Leu Leu Leu
 395                 400                 405                 410

 ccc aaa ttt gat gag gta tat gcc cgc tct tac tgc ttc tca gcc aac     1360
 Pro Lys Phe Asp Glu Val Tyr Ala Arg Ser Tyr Cys Phe Ser Ala Asn
                 415                 420                 425

 tac atc tac cac ttg ttt gtg aac ggt tac aaa ttc aca gag gag act     1408
 Tyr Ile Tyr His Leu Phe Val Asn Gly Tyr Lys Phe Thr Glu Glu Thr
             430                 435                 440

 tgg ccc caa ata cac ttt gaa aaa gaa gtg ggg aat agc agc ata gcc     1456
 Trp Pro Gln Ile His Phe Glu Lys Glu Val Gly Asn Ser Ser Ile Ala
         445                 450                 455

 tgg tct ctt ggc tac atg ctc agc ctg acc aac cag atc cca gct gaa     1504
 Trp Ser Leu Gly Tyr Met Leu Ser Leu Thr Asn Gln Ile Pro Ala Glu
     460                 465                 470

 agc cct ctg atc cgt ctg ccc ata gaa cca cct gtc ttt gtg ggc acc     1552
 Ser Pro Leu Ile Arg Leu Pro Ile Glu Pro Pro Val Phe Val Gly Thr
 475                 480                 485                 490

 ctc gct ttc ttc aca gtg gca gcc ttg ctg tgt ctg gca ttt ctt gca     1600
 Leu Ala Phe Phe Thr Val Ala Ala Leu Leu Cys Leu Ala Phe Leu Ala
                 495                 500                 505

 tac ctg tgt tca gca acc aga aga aag agg cac tcc gag cat gcc ttt     1648
 Tyr Leu Cys Ser Ala Thr Arg Arg Lys Arg His Ser Glu His Ala Phe
             510                 515                 520

 gac cat gca gtg gat tct gac tga gccttcaaag cagctcctgg agtccaatgg    1702
 Asp His Ala Val Asp Ser Asp 
         525

 ctgcttagag tcagcctggg tggcaccagg caatgcaggt gaagtggctg ccttcaggaa   1762

 atacaactaa ctaaaatcaa acacctaggt cacgtgcctc tcaaatactg atttctgcca   1822

 cagcacctct tgaggcatcc cttggctatt ctgtgcatat tgttcttcag agacctcact   1882

 acccacatgc tgatctattg gggaacagag aagagacagg ccactaaggt caggctcttt   1942

 atattaagtt ccccagagga agagtaagtt gagaaggtat cagtttaatg ttgaagaatt   2002

 gacctcaggg ctcagtttcc atttccctcc ctcagtattc ttcctggcaa gatacccatt   2062

 aagcatttcg ccaatcagaa tctcatttta tagtttttcc cattggtctt taactaagac   2122

 tttcttgtag caatctcgta agcagtgaac cccctcagat cagtagaata tagtatctgg   2182

 gggagaagac ttacttcctt cagggcagca gccacagcca ggcttctgtc atacaggtag   2242

 atcccgaagc acagagacat aaaaaaggtc tcccagaaaa ctatagacca ttctccaagt   2302

 ggaattccca cttagggctc tggtcactag attgcaacct gtgtgtttgt catcatcctc   2362

 atctcaccat tgtattgcta tgccctccca taaaaacaca ttgatcccta gcaagattat   2422

 tgcattccag attttactgc ctttgctagg cttttgctta gcaaagggct gactttccat   2482

 tgttatcatg gtgtatatat ttttgtcacc attcccacaa gtatacttga tgttgtcata   2542

 gaacgaacat cctactctat gatttactaa ccaattactt tcccagatca tagacctctc   2602

 tgcatagtag tcataggtct tgactttggg gaaagaaaag gaagctgcag gaatatttat   2662

 ctccaaagtc gaatgagaaa gaactccagc aaatccaatg gctacaaact aaaaatcagc   2722

 attatttcat attgctgttt cttagctgaa tatggaataa agaactatta ttttattttg   2782

 aaaaaaaaaa aaaaa                                                    2797




      <210> 283
      <211> 843
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (86)..(703)

      <400> 283
 ccggcggtga gaatccaggg agaggagcgg aaacagaaga ggggcagaag accggggcac     60

 ttgtgggttg cagagcccct cagcc  atg ttg gga gcc aag cca cac tgg cta     112
                              Met Leu Gly Ala Lys Pro His Trp Leu
                                1               5

 cca ggt ccc cta cac agt ccc ggg ctg ccc ttg gtt ctg gtg ctt ctg      160
 Pro Gly Pro Leu His Ser Pro Gly Leu Pro Leu Val Leu Val Leu Leu
  10                  15                  20                  25

 gcc ctg ggg gcc ggg tgg gcc cag gag ggg tca gag ccc gtc ctg ctg      208
 Ala Leu Gly Ala Gly Trp Ala Gln Glu Gly Ser Glu Pro Val Leu Leu
                  30                  35                  40

 gag ggg gag tgc ctg gtg gtc tgt gag cct ggc cga gct gct gca ggg      256
 Glu Gly Glu Cys Leu Val Val Cys Glu Pro Gly Arg Ala Ala Ala Gly
              45                  50                  55

 ggg ccc ggg gga gca gcc ctg gga gag gca ccc cct ggg cga gtg gca      304
 Gly Pro Gly Gly Ala Ala Leu Gly Glu Ala Pro Pro Gly Arg Val Ala
          60                  65                  70

 ttt gct gcg gtc cga agc cac cac cat gag cca gca ggg gaa acc ggc      352
 Phe Ala Ala Val Arg Ser His His His Glu Pro Ala Gly Glu Thr Gly
      75                  80                  85

 aat ggc acc agt ggg gcc atc tac ttc gac cag gta atg gtg aac gag      400
 Asn Gly Thr Ser Gly Ala Ile Tyr Phe Asp Gln Val Met Val Asn Glu
  90                  95                 100                 105

 ggc ggt ggc ttt gac cgg gcc tct ggc tcc ttc gta gcc cct gtc cgg      448
 Gly Gly Gly Phe Asp Arg Ala Ser Gly Ser Phe Val Ala Pro Val Arg
                 110                 115                 120

 ggt gtc tac agc ttc cgg ttc cat gtg gtg aag gtg tac aac cgc caa      496
 Gly Val Tyr Ser Phe Arg Phe His Val Val Lys Val Tyr Asn Arg Gln
             125                 130                 135

 act gtc cag gtg agc ctg gtg ctg aac acg tgg cct gtc atc tca gcc      544
 Thr Val Gln Val Ser Leu Val Leu Asn Thr Trp Pro Val Ile Ser Ala
         140                 145                 150

 ttt gcc aat gat cct gac gtg acc cgg gag gca gcc acc agc tct gtg      592
 Phe Ala Asn Asp Pro Asp Val Thr Arg Glu Ala Ala Thr Ser Ser Val
     155                 160                 165

 cta ctg ccc ttg gac cct ggg gac cga gtg tct ctg cgc ctg cgt cgg      640
 Leu Leu Pro Leu Asp Pro Gly Asp Arg Val Ser Leu Arg Leu Arg Arg
 170                 175                 180                 185

 ggg aat cta ctg ggt ggt tgg aaa tac tca agt ttc tct ggc ttc ctc      688
 Gly Asn Leu Leu Gly Gly Trp Lys Tyr Ser Ser Phe Ser Gly Phe Leu
                 190                 195                 200

 atc ttc cct ctc tga ggacccaagt ctttcaagca caagaatcca gcccctgaca      743
 Ile Phe Pro Leu 
             205

 actttcttct gccctctctt gccccagaaa cagcagaggc aggagagaga ctccctctgg    803

 ctcctccggt tcccccaccc cagcttcctg ctcaatgctg                          843




      <210> 284
      <211> 879
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (42)..(758)

      <400> 284
 ggctcgccgg gaccagatcc gcgagcccgt cagcctgcgc c    atg ggc tgc gac      53
                                                  Met Gly Cys Asp
                                                    1

 ggc cgc gtg tcg ggg ctg ctc cgc cgc aac ctg cag ccc acg ctc acc      101
 Gly Arg Val Ser Gly Leu Leu Arg Arg Asn Leu Gln Pro Thr Leu Thr
   5                  10                  15                  20

 tac tgg agc gtc ttc ttc agc ttc ggc ctg tgc atc gcc ttc ctg ggg      149
 Tyr Trp Ser Val Phe Phe Ser Phe Gly Leu Cys Ile Ala Phe Leu Gly
                  25                  30                  35

 ccc acg ctg ctg gac ctg cgc tgt cag acg cac agc tcg ctg ccc cag      197
 Pro Thr Leu Leu Asp Leu Arg Cys Gln Thr His Ser Ser Leu Pro Gln
              40                  45                  50

 atc tcc tgg gtc ttc ttc tcg cag cag ctc tgc ctc ctg ctg ggc agc      245
 Ile Ser Trp Val Phe Phe Ser Gln Gln Leu Cys Leu Leu Leu Gly Ser
          55                  60                  65

 gcc ctc ggg ggc gtc ttc aaa agg acc ctg gcc cag tca cta tgg gcc      293
 Ala Leu Gly Gly Val Phe Lys Arg Thr Leu Ala Gln Ser Leu Trp Ala
      70                  75                  80

 ctg ttc acc tcc tct ctg gcc atc tcc ctg gtg ttt gcc gtc atc ccc      341
 Leu Phe Thr Ser Ser Leu Ala Ile Ser Leu Val Phe Ala Val Ile Pro
  85                  90                  95                 100

 ttc tgc cgc gac gtg aag gtg ctg gcc tca gtc atg gcg ctg gcg ggc      389
 Phe Cys Arg Asp Val Lys Val Leu Ala Ser Val Met Ala Leu Ala Gly
                 105                 110                 115

 ttg gcc atg ggc tgc atc gac acc gtg gcc aac atg cag ctg gta agg      437
 Leu Ala Met Gly Cys Ile Asp Thr Val Ala Asn Met Gln Leu Val Arg
             120                 125                 130

 atg tac cag aag gac tcg gcc gtc ttc ctc cag gtg ctc cat ttc ttc      485
 Met Tyr Gln Lys Asp Ser Ala Val Phe Leu Gln Val Leu His Phe Phe
         135                 140                 145

 gtg ggc ttt ggt gct ctg ctg agc ccc ctt att gct gac cct ttc ctg      533
 Val Gly Phe Gly Ala Leu Leu Ser Pro Leu Ile Ala Asp Pro Phe Leu
     150                 155                 160

 tct gag gcc aac tgc ttg cct gcc aat agc acg gcc aac acc acc tcc      581
 Ser Glu Ala Asn Cys Leu Pro Ala Asn Ser Thr Ala Asn Thr Thr Ser
 165                 170                 175                 180

 cga ggc cac ctg ttc cat gtc tcc agg gtg ctg ggc cag cac cac gta      629
 Arg Gly His Leu Phe His Val Ser Arg Val Leu Gly Gln His His Val
                 185                 190                 195

 gat gcc aag cct tgg tcc aac cag acg ttc cca ggg ctg act cca aag      677
 Asp Ala Lys Pro Trp Ser Asn Gln Thr Phe Pro Gly Leu Thr Pro Lys
             200                 205                 210

 gac ggg gca ggg acc cgg agt gtc cta tgc ctt ctg gat cat ggc cat      725
 Asp Gly Ala Gly Thr Arg Ser Val Leu Cys Leu Leu Asp His Gly His
         215                 220                 225

 cat caa tct tcc agt gcc cat tgg ctg tgc tga tgctgctg tccaaggagc      776
 His Gln Ser Ser Ser Ala His Trp Leu Cys 
     230                 235

 ggctgctgac ctgctgtccc ccagaggagg ccctgcttct gtctctgatg agcttgcctt    836

 ggaaaacaca gcctctgaga aggaagatgc ttctccatgc cca                      879




      <210> 285
      <211> 2791
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (402)..(2051)

      <400> 285
 catatgttag ccaacggaat gatccccacc atattagaca atcaggctgg ctaggttggg     60

 catggtggtt cacacctgta attccagcac tttgggaggc caaggcatgt ggatcacttg    120

 aggtctggag ttcagaccag cctggccaac atggtgaaac cccatctgta ctaagaatac    180

 aaaattagct ggacgtgatg gtgcacgtat gtaatcccag ctattcagga ggctgaggca    240

 ggagaattgc ttgaacccgg gaggcagagg ttgcagtgag ccaagatcgt tccactgcac    300

 tctagcctgg gcaacagaga gagactccat ctagagttcc agcaactttg taggctgaga    360

 caggaaaatc gcttgaggcc aggagttcta ggctacagtg t    atg atg att gtg     413
                                                  Met Met Ile Val
                                                    1

 cct gtg aat agc cac tgc act cca gcc tgg gca aca aaa cga gcc tcc      461
 Pro Val Asn Ser His Cys Thr Pro Ala Trp Ala Thr Lys Arg Ala Ser
   5                  10                  15                  20

 atc tca aga ttg agc caa aaa gaa aac ctg aag aga cca gta aca ggt      509
 Ile Ser Arg Leu Ser Gln Lys Glu Asn Leu Lys Arg Pro Val Thr Gly
                  25                  30                  35

 aac aag att gca ccc atc atg cca ctg cat tca agc ctg ggt tac agg      557
 Asn Lys Ile Ala Pro Ile Met Pro Leu His Ser Ser Leu Gly Tyr Arg
              40                  45                  50

 gcc aga ccc tac tgg agc gtc ttc ttc agc ttc ggc ctg tgc atc gcc      605
 Ala Arg Pro Tyr Trp Ser Val Phe Phe Ser Phe Gly Leu Cys Ile Ala
          55                  60                  65

 ttc ctg ggg ccc acg ctg ctg gac ctg cgc tgt cag acg cac agc tcg      653
 Phe Leu Gly Pro Thr Leu Leu Asp Leu Arg Cys Gln Thr His Ser Ser
      70                  75                  80

 ctg ccc cag atc tcc tgg gtc ttc ttc tcg cag cag ctc tgc ctc ctg      701
 Leu Pro Gln Ile Ser Trp Val Phe Phe Ser Gln Gln Leu Cys Leu Leu
  85                  90                  95                 100

 ctg ggc agc gcc ctc ggg ggc gtc ttc aaa agg acc ctg gcc cag tca      749
 Leu Gly Ser Ala Leu Gly Gly Val Phe Lys Arg Thr Leu Ala Gln Ser
                 105                 110                 115

 cta tgg gcc ctg ttc acc tcc tct ctg gcc atc tcc ctg gtg ttt gcc      797
 Leu Trp Ala Leu Phe Thr Ser Ser Leu Ala Ile Ser Leu Val Phe Ala
             120                 125                 130

 gtc atc ccc ttc tgc cgc gac gtg aag gtg ctg gcc tca gtc atg gcg      845
 Val Ile Pro Phe Cys Arg Asp Val Lys Val Leu Ala Ser Val Met Ala
         135                 140                 145

 ctg gcg ggc ttg gcc atg ggc tgc atc gac acc gtg gcc aac atg cag      893
 Leu Ala Gly Leu Ala Met Gly Cys Ile Asp Thr Val Ala Asn Met Gln
     150                 155                 160

 ctg gta agg atg tac cag aag gac tcg gcc gtc ttc ctc cag gtg ctc      941
 Leu Val Arg Met Tyr Gln Lys Asp Ser Ala Val Phe Leu Gln Val Leu
 165                 170                 175                 180

 cat ttc ttc gtg ggc ttt ggt gct ctg ctg agc ccc ctt att gct gac      989
 His Phe Phe Val Gly Phe Gly Ala Leu Leu Ser Pro Leu Ile Ala Asp
                 185                 190                 195

 cct ttc ctg tct gag gcc aac tgc ttg cct gcc aat agc acg gcc aac     1037
 Pro Phe Leu Ser Glu Ala Asn Cys Leu Pro Ala Asn Ser Thr Ala Asn
             200                 205                 210

 acc acc tcc cga ggc cac ctg ttc cat gtc tcc agg gtg ctg ggc cag     1085
 Thr Thr Ser Arg Gly His Leu Phe His Val Ser Arg Val Leu Gly Gln
         215                 220                 225

 cac cac gta gat gcc aag cct tgg tcc aac cag acg ttc cca ggg ctg     1133
 His His Val Asp Ala Lys Pro Trp Ser Asn Gln Thr Phe Pro Gly Leu
     230                 235                 240

 act cca aag gac ggg gca ggg acc cga gtg tcc tat gcc ttc tgg atc     1181
 Thr Pro Lys Asp Gly Ala Gly Thr Arg Val Ser Tyr Ala Phe Trp Ile
 245                 250                 255                 260

 atg gcc atc atc aat ctt cca gtg ccc acg gct gtg ctg atg ctg ctg     1229
 Met Ala Ile Ile Asn Leu Pro Val Pro Thr Ala Val Leu Met Leu Leu
                 265                 270                 275

 tcc aag gag cgg ctg ctg acc tgc tgt ccc cag agg agg ccc ctg ctt     1277
 Ser Lys Glu Arg Leu Leu Thr Cys Cys Pro Gln Arg Arg Pro Leu Leu
             280                 285                 290

 ctg tct gct gat gag ctt gcc ttg gag aca cag cct cct gag aag gaa     1325
 Leu Ser Ala Asp Glu Leu Ala Leu Glu Thr Gln Pro Pro Glu Lys Glu
         295                 300                 305

 gat gcc tcc tca ctg ccc cca aag ttt cag tca cac cta ggg cat gag     1373
 Asp Ala Ser Ser Leu Pro Pro Lys Phe Gln Ser His Leu Gly His Glu
     310                 315                 320

 gac ctg ttc agc tgc tgc caa agg aag aac ctc aga gga gcc cct tat     1421
 Asp Leu Phe Ser Cys Cys Gln Arg Lys Asn Leu Arg Gly Ala Pro Tyr
 325                 330                 335                 340

 tcc ttc ttt gcc atc cac atc acg ggc gcc ctg gta ctg ttc atg acg     1469
 Ser Phe Phe Ala Ile His Ile Thr Gly Ala Leu Val Leu Phe Met Thr
                 345                 350                 355

 gat ggg ttg acg ggt gcc tat tcc gcc ttc gtg tac agc tat gct gtg     1517
 Asp Gly Leu Thr Gly Ala Tyr Ser Ala Phe Val Tyr Ser Tyr Ala Val
             360                 365                 370

 gag aag ccc ctg tct gtg gga cac aag gtg gct ggc tac ctc ccc agc     1565
 Glu Lys Pro Leu Ser Val Gly His Lys Val Ala Gly Tyr Leu Pro Ser
         375                 380                 385

 ctc ttc tgg ggc ttc atc aca ctg ggc cgg ctc ctc tcc att ccc ata     1613
 Leu Phe Trp Gly Phe Ile Thr Leu Gly Arg Leu Leu Ser Ile Pro Ile
     390                 395                 400

 tcc tca aga atg aag ccg gcc acc atg gtt ttc atc aac gtg gtt ggc     1661
 Ser Ser Arg Met Lys Pro Ala Thr Met Val Phe Ile Asn Val Val Gly
 405                 410                 415                 420

 gtg gtg gtg acg ttc ctg gtg ctg ctt att ttc tcc tac aac gtc gtc     1709
 Val Val Val Thr Phe Leu Val Leu Leu Ile Phe Ser Tyr Asn Val Val
                 425                 430                 435

 ttc ctg ttc gtg ggg acg gca agc ctg ggc ctg ttt ctc agc agc acc     1757
 Phe Leu Phe Val Gly Thr Ala Ser Leu Gly Leu Phe Leu Ser Ser Thr
             440                 445                 450

 ttc ccc agc atg ctg gcc tac acg gag gac tcg ctg cag tac aaa ggc     1805
 Phe Pro Ser Met Leu Ala Tyr Thr Glu Asp Ser Leu Gln Tyr Lys Gly
         455                 460                 465

 tgt gca acc aca gtg ctg gtg aca ggg gca gga gtt ggc gag atg gtg     1853
 Cys Ala Thr Thr Val Leu Val Thr Gly Ala Gly Val Gly Glu Met Val
     470                 475                 480

 ctg cag atg ctg gtt ggt tcg ata ttc cag gct cag ggc agc tat agt     1901
 Leu Gln Met Leu Val Gly Ser Ile Phe Gln Ala Gln Gly Ser Tyr Ser
 485                 490                 495                 500

 ttc ctg gtc tgt ggc gtg atc ttt ggt tgt ctg gct ttt acc ttc tat     1949
 Phe Leu Val Cys Gly Val Ile Phe Gly Cys Leu Ala Phe Thr Phe Tyr
                 505                 510                 515

 atc ttg ctc ctg ttt ttc cac agg atg cac cct gga ctc cca tca gtt     1997
 Ile Leu Leu Leu Phe Phe His Arg Met His Pro Gly Leu Pro Ser Val
             520                 525                 530

 cct acc caa gac aga tca att gga atg gaa aac tct gag tgc tac cag     2045
 Pro Thr Gln Asp Arg Ser Ile Gly Met Glu Asn Ser Glu Cys Tyr Gln
         535                 540                 545

 agg taa aactgggtga agaaggcaag agaagacttt cagcctcttg atcaccagca      2101
 Arg 


 cgaccatact gtttcagaaa gctgggtggt ggtggaggcg ctctctcaat ggctattcaa   2161

 gtcttctcca ctaaaacttg gttgggtaga ggaaattaaa ttgagtcctg gtacctggtc   2221

 aaaatcatta gaagtttacc tggcttctca agttatcttc ttccctggtt cagactgttg   2281

 gtaagagctg tccagatacc cagatgggaa ggaaggagac agccgcgcgc ttcactccat   2341

 ttgtcacctc atgcatgggc catactctgg gtttgagatc attcttcatt gaagtttgta   2401

 aaaataggtt gaaattgtaa agctccatga tcactgctat atgtagatat atttcaattt   2461

 aagcaaaaca agctgcaagt tattccctgg catgctcaaa ggattttcgt gcttttcact   2521

 taatagtcca aagtctctta aattcctgct gcagacatca atagcttatc tatattctca   2581

 aacaccaaaa ggaaaagttg aatcttgctc tctttggtat actaatgtag tggtatgcta   2641

 agctggctca taccaactta gaaaagctga ttgtaaaatt ttcattttga cagctggtta   2701

 ttaaatgcag ccattattaa aaatcaaatc atacaaactt ataattaaat caattacatt   2761

 taaaacaaag gtaataaata ttcaaagcat                                    2791




      <210> 286
      <211> 2026
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (284)..(2026)

      <400> 286
 gcgagggagg attccccggc cggcgcccgc ccccgggcta aagtgcggcg cgggtggggc     60

 tggtcacgcg cctggcttcc tgcagtgcga acctgggaaa tccaggcgac ttcgcagttg    120

 ccgaagggat ctgaagaagt gggatgtgca aaagcgccgg ctggaaatcc cggctgtgtc    180

 tccgtcaact ctttacgcaa cagaggtctc cccctgccct tggtttctac cgggccgcct    240

 gctcccactc ggcgaaaaaa attacacaac agcagccgcg gcg  atg acg tgg agg     295
                                                  Met Thr Trp Arg
                                                    1

 gct gcc gcc tcc acg tgc gcg gcg ctc ctg att ctg ctg tgg gcg ctg      343
 Ala Ala Ala Ser Thr Cys Ala Ala Leu Leu Ile Leu Leu Trp Ala Leu
   5                  10                  15                  20

 acg acc gaa ggt gat ctg aaa gta gag atg atg gca ggg ggg act cag      391
 Thr Thr Glu Gly Asp Leu Lys Val Glu Met Met Ala Gly Gly Thr Gln
                  25                  30                  35

 atc aca ccc ctg aat gac aat gtc acc ata ttc tgc aat atc ttt tat      439
 Ile Thr Pro Leu Asn Asp Asn Val Thr Ile Phe Cys Asn Ile Phe Tyr
              40                  45                  50

 tcc caa ccc ctc aac atc acg tct atg ggt atc acc tgg ttt tgg aag      487
 Ser Gln Pro Leu Asn Ile Thr Ser Met Gly Ile Thr Trp Phe Trp Lys
          55                  60                  65

 agt ctg acg ttt gac aaa gaa gtc aaa gtc ttt gaa ttt ttt gga gat      535
 Ser Leu Thr Phe Asp Lys Glu Val Lys Val Phe Glu Phe Phe Gly Asp
      70                  75                  80

 cac caa gag gca ttc cga cct gga gcc att gtg tct cca tgg agg ctg      583
 His Gln Glu Ala Phe Arg Pro Gly Ala Ile Val Ser Pro Trp Arg Leu
  85                  90                  95                 100

 aag agt ggg gac gcc tca ctg cgg ctg cct gga atc cag ctg gag gaa      631
 Lys Ser Gly Asp Ala Ser Leu Arg Leu Pro Gly Ile Gln Leu Glu Glu
                 105                 110                 115

 gca gga gag tac cga tgt gag gtg gtg gtc acc cct ctg aag gca cag      679
 Ala Gly Glu Tyr Arg Cys Glu Val Val Val Thr Pro Leu Lys Ala Gln
             120                 125                 130

 gga aca gtc cag ctt gaa gtt gtg gct tcc cca gcc agc aga ttg ttg      727
 Gly Thr Val Gln Leu Glu Val Val Ala Ser Pro Ala Ser Arg Leu Leu
         135                 140                 145

 ctg gat caa gtg ggc atg aaa gag aat gaa gac aaa tat atg tgt gag      775
 Leu Asp Gln Val Gly Met Lys Glu Asn Glu Asp Lys Tyr Met Cys Glu
     150                 155                 160

 tca agt ggg ttc tac cca gag gct att aat ata aca tgg gag aag cag      823
 Ser Ser Gly Phe Tyr Pro Glu Ala Ile Asn Ile Thr Trp Glu Lys Gln
 165                 170                 175                 180

 acc cag aag ttt ccc cat ccc ata gag att tct gag gat gtc atc act      871
 Thr Gln Lys Phe Pro His Pro Ile Glu Ile Ser Glu Asp Val Ile Thr
                 185                 190                 195

 ggt ccc acc atc aag aat atg gat ggc aca ttt aat gtc act agc tgc      919
 Gly Pro Thr Ile Lys Asn Met Asp Gly Thr Phe Asn Val Thr Ser Cys
             200                 205                 210

 ttg aag ctg aac tcc tct cag gaa gac cct ggg act gtc tac cag tgt      967
 Leu Lys Leu Asn Ser Ser Gln Glu Asp Pro Gly Thr Val Tyr Gln Cys
         215                 220                 225

 gtg gta cgg cat gcg tcc ttg cat acc ccc ttg agg agc aac ttt acc     1015
 Val Val Arg His Ala Ser Leu His Thr Pro Leu Arg Ser Asn Phe Thr
     230                 235                 240

 ctg act gct gct cgg cac agt ctt tct gaa act gag aag aca gat aat     1063
 Leu Thr Ala Ala Arg His Ser Leu Ser Glu Thr Glu Lys Thr Asp Asn
 245                 250                 255                 260

 ttt tcc att cat tgg tgg cct att tca ttc att ggt gtt gga ctg gtt     1111
 Phe Ser Ile His Trp Trp Pro Ile Ser Phe Ile Gly Val Gly Leu Val
                 265                 270                 275

 tta tta att gtt ttg att cct tgg aaa aag gta agg ggc tcc aaa gca     1159
 Leu Leu Ile Val Leu Ile Pro Trp Lys Lys Val Arg Gly Ser Lys Ala
             280                 285                 290

 aag ttc agc cct gtg tct tgg gct agt aaa aag ctt tta gag cag ctg     1207
 Lys Phe Ser Pro Val Ser Trp Ala Ser Lys Lys Leu Leu Glu Gln Leu
         295                 300                 305

 ctg cca acc tta caa gcc tca agg gac agg cct gct gga aag gac ttt     1255
 Leu Pro Thr Leu Gln Ala Ser Arg Asp Arg Pro Ala Gly Lys Asp Phe
     310                 315                 320

 gtc agt ccc tct tca cca tca ggt gtt ggg aat gtt ggc tgt gtt cca     1303
 Val Ser Pro Ser Ser Pro Ser Gly Val Gly Asn Val Gly Cys Val Pro
 325                 330                 335                 340

 atc cag ttt cct atc aca gag gac cta gct gtc aca tac cat ctg acc     1351
 Ile Gln Phe Pro Ile Thr Glu Asp Leu Ala Val Thr Tyr His Leu Thr
                 345                 350                 355

 tct gta tgg tgg ttt gtg act ctg ggg gtc ttg ccc caa tcc aac tac     1399
 Ser Val Trp Trp Phe Val Thr Leu Gly Val Leu Pro Gln Ser Asn Tyr
             360                 365                 370

 tgc aca atc tct ccc atg gtt cta ggg aat ctc agg agc ctt atg ggc     1447
 Cys Thr Ile Ser Pro Met Val Leu Gly Asn Leu Arg Ser Leu Met Gly
         375                 380                 385

 caa gta ggt cta gga aac cag cag ggc aga gag cta gga cct tgt gca     1495
 Gln Val Gly Leu Gly Asn Gln Gln Gly Arg Glu Leu Gly Pro Cys Ala
     390                 395                 400

 gag aaa cag gta gcc ctg cag gca gca gaa aaa ttc aga gat gaa caa     1543
 Glu Lys Gln Val Ala Leu Gln Ala Ala Glu Lys Phe Arg Asp Glu Gln
 405                 410                 415                 420

 cat gtc ttc tat agc cac tca ata agg aaa gaa ggt atg ttt ata cct     1591
 His Val Phe Tyr Ser His Ser Ile Arg Lys Glu Gly Met Phe Ile Pro
                 425                 430                 435

 cac ata aat aat tca att gag gga cag cta att ttg aaa gac aag ttt     1639
 His Ile Asn Asn Ser Ile Glu Gly Gln Leu Ile Leu Lys Asp Lys Phe
             440                 445                 450

 att act cag aca gcc cct gat atc aga agg aag cta gag aaa cag gcc     1687
 Ile Thr Gln Thr Ala Pro Asp Ile Arg Arg Lys Leu Glu Lys Gln Ala
         455                 460                 465

 atg gga tta gat agc acc tta caa aac ctc ctg aag gta gcc acc tcg     1735
 Met Gly Leu Asp Ser Thr Leu Gln Asn Leu Leu Lys Val Ala Thr Ser
     470                 475                 480

 gtc ttt tat aat agg gac cag gag gag gcc cag ggg aag gag agg aaa     1783
 Val Phe Tyr Asn Arg Asp Gln Glu Glu Ala Gln Gly Lys Glu Arg Lys
 485                 490                 495                 500

 cac aag aaa aag gca gag act ctg gtg gcc act ttg tat aaa acc cag     1831
 His Lys Lys Lys Ala Glu Thr Leu Val Ala Thr Leu Tyr Lys Thr Gln
                 505                 510                 515

 tat ccc caa ggt aca cct gct agt tgc tac caa tgt ggc aaa cta ggg     1879
 Tyr Pro Gln Gly Thr Pro Ala Ser Cys Tyr Gln Cys Gly Lys Leu Gly
             520                 525                 530

 cac ttc aaa agg gac tgc cca ggc agc aag aag aag cca cct caa ccc     1927
 His Phe Lys Arg Asp Cys Pro Gly Ser Lys Lys Lys Pro Pro Gln Pro
         535                 540                 545

 tgt cca gta tac aat ggg gac cac tgg aag gca gac tgt cct ggg aag     1975
 Cys Pro Val Tyr Asn Gly Asp His Trp Lys Ala Asp Cys Pro Gly Lys
     550                 555                 560

 cat agg tca ctg agt cca gag cca gtc tca caa atg gtc cag cag gac     2023
 His Arg Ser Leu Ser Pro Glu Pro Val Ser Gln Met Val Gln Gln Asp
 565                 570                 575                 580

 tga                                                                 2026
 






      <210> 287
      <211> 3070
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (202)..(1671)

      <400> 287
 agcggcggca gcagcggccg cggcgacagc tccagctccg gctccggctc cggctccggc     60

 tccggctccc gcgcctgccc cgctcggccc agcgcgcccg ggctccgcgc cccgaccccg    120

 ccgccgcgcc tgccgggggc ctcgggcgcc cccgccgccc gcctcacgct gaagttcctg    180

 gccgtgctgc tggccgcggg c  atg ctg gcg ttc ctc ggt gcc gtc atc tgc     231
                          Met Leu Ala Phe Leu Gly Ala Val Ile Cys
                            1               5                  10

 atc atc gcc agc gtg ccc ctg gcg gcc agc ccg gcg cgg gcg ctg ccc      279
 Ile Ile Ala Ser Val Pro Leu Ala Ala Ser Pro Ala Arg Ala Leu Pro
                  15                  20                  25

 ggc ggc gcc gac aat gct tcg gtc gcc tcg ggc gcc gcc gcg tcc ccg      327
 Gly Gly Ala Asp Asn Ala Ser Val Ala Ser Gly Ala Ala Ala Ser Pro
              30                  35                  40

 ggc ccg cag cgg agc ctg agc gcg ctg cac ggc gcg ggc ggt tca gcc      375
 Gly Pro Gln Arg Ser Leu Ser Ala Leu His Gly Ala Gly Gly Ser Ala
          45                  50                  55

 ggg ccc ccc gcg ctg ccc ggg gca ccc gcg gcc agc gcg cac ccg ctg      423
 Gly Pro Pro Ala Leu Pro Gly Ala Pro Ala Ala Ser Ala His Pro Leu
      60                  65                  70

 ccg ccc ggg ccc ctg ttc agc cgc ttc ctg tgc acg ccg ctg gct gct      471
 Pro Pro Gly Pro Leu Phe Ser Arg Phe Leu Cys Thr Pro Leu Ala Ala
  75                  80                  85                  90

 gcc tgc ccg tcg ggg gcc cag cag ggg gac gcg gcg ggc gct gcg ccg      519
 Ala Cys Pro Ser Gly Ala Gln Gln Gly Asp Ala Ala Gly Ala Ala Pro
                  95                 100                 105

 ggc gag cgc gaa gag ctg ctg ctg ctg cag agc acg gcc gag cag ctg      567
 Gly Glu Arg Glu Glu Leu Leu Leu Leu Gln Ser Thr Ala Glu Gln Leu
             110                 115                 120

 cgc cag acg gcg ctg cag cag gag gcg cgc atc cgc gcc gac cag gac      615
 Arg Gln Thr Ala Leu Gln Gln Glu Ala Arg Ile Arg Ala Asp Gln Asp
         125                 130                 135

 acc atc cgt gag ctc acc ggc aag ctg ggc cgc tgc gag agc ggc ctg      663
 Thr Ile Arg Glu Leu Thr Gly Lys Leu Gly Arg Cys Glu Ser Gly Leu
     140                 145                 150

 ccg cgc ggc ctc cag ggc gcc ggg ccc cgc cgc gac acc atg gcc gac      711
 Pro Arg Gly Leu Gln Gly Ala Gly Pro Arg Arg Asp Thr Met Ala Asp
 155                 160                 165                 170

 ggg ccc tgg gac tcg cct gcg ctc att ctg gag ctg gag gac gcc gtg      759
 Gly Pro Trp Asp Ser Pro Ala Leu Ile Leu Glu Leu Glu Asp Ala Val
                 175                 180                 185

 cgc gcc ctg cgg gac cgc atc gac cgc ctg gag cag gag ctt cca gcc      807
 Arg Ala Leu Arg Asp Arg Ile Asp Arg Leu Glu Gln Glu Leu Pro Ala
             190                 195                 200

 cgt gtg aac ctc tca gct gcc cca gcc cca gtc tct gct gtg ccc acc      855
 Arg Val Asn Leu Ser Ala Ala Pro Ala Pro Val Ser Ala Val Pro Thr
         205                 210                 215

 ggc cta cac tcc aag atg gac cag ctg gag ggg cag ctg ctg gcc cag      903
 Gly Leu His Ser Lys Met Asp Gln Leu Glu Gly Gln Leu Leu Ala Gln
     220                 225                 230

 gtg ctg gca ctg gag aag gag cgt gtg gcc ctc agc cac agc agc cgc      951
 Val Leu Ala Leu Glu Lys Glu Arg Val Ala Leu Ser His Ser Ser Arg
 235                 240                 245                 250

 cgg cag agg cag gaa gtg gaa aag gag ttg gac gtc ctg cag ggt cgt      999
 Arg Gln Arg Gln Glu Val Glu Lys Glu Leu Asp Val Leu Gln Gly Arg
                 255                 260                 265

 gtg gct gag ctg gag cac ggg tcc tca gcc tac agt cct cca gat gcc     1047
 Val Ala Glu Leu Glu His Gly Ser Ser Ala Tyr Ser Pro Pro Asp Ala
             270                 275                 280

 ttc aag atc agc atc ccc atc cgt aac aac tac atg tac gcc cgc gtg     1095
 Phe Lys Ile Ser Ile Pro Ile Arg Asn Asn Tyr Met Tyr Ala Arg Val
         285                 290                 295

 cgg aag gct ctg ccc gag ctc tac gca ttc acc gcc tgc atg tgg ctg     1143
 Arg Lys Ala Leu Pro Glu Leu Tyr Ala Phe Thr Ala Cys Met Trp Leu
     300                 305                 310

 cgg tcc agg tcc agc ggc acc ggc cag ggc acc ccc ttc tcc tac tca     1191
 Arg Ser Arg Ser Ser Gly Thr Gly Gln Gly Thr Pro Phe Ser Tyr Ser
 315                 320                 325                 330

 gtg ccc ggg cag gcc aac gag att gta ctg cta gag gcg ggc cat gag     1239
 Val Pro Gly Gln Ala Asn Glu Ile Val Leu Leu Glu Ala Gly His Glu
                 335                 340                 345

 ccc atg gag ctg ctg atc aac gac aag gtg gcc cag ctg ccc ctg agc     1287
 Pro Met Glu Leu Leu Ile Asn Asp Lys Val Ala Gln Leu Pro Leu Ser
             350                 355                 360

 ctg aag gac aat ggc tgg cac cac atc tgc atc gcc tgg acc aca agg     1335
 Leu Lys Asp Asn Gly Trp His His Ile Cys Ile Ala Trp Thr Thr Arg
         365                 370                 375

 gat ggc cta tgg tct gcc tac cag gac ggg gag ctg cag ggc tcc ggt     1383
 Asp Gly Leu Trp Ser Ala Tyr Gln Asp Gly Glu Leu Gln Gly Ser Gly
     380                 385                 390

 gag aac ctg gct gcc tgg cac ccc atc aag cct cat ggg atc ctt atc     1431
 Glu Asn Leu Ala Ala Trp His Pro Ile Lys Pro His Gly Ile Leu Ile
 395                 400                 405                 410

 ttg ggc cag gag cag gat acc ctg ggt ggc cgg ttt gat gcc acc cag     1479
 Leu Gly Gln Glu Gln Asp Thr Leu Gly Gly Arg Phe Asp Ala Thr Gln
                 415                 420                 425

 gcc ttt gtc ggt gac att gcc cag ttt aac ctg tgg gac cac gcc ctg     1527
 Ala Phe Val Gly Asp Ile Ala Gln Phe Asn Leu Trp Asp His Ala Leu
             430                 435                 440

 aca cca gcc cag gtc ctg ggc att gcc aac tgc act gcg cca ctg ctg     1575
 Thr Pro Ala Gln Val Leu Gly Ile Ala Asn Cys Thr Ala Pro Leu Leu
         445                 450                 455

 ggc aac gtc ctt ccc tgg gaa gac aag ttg gtg gag gcc ttt ggg ggt     1623
 Gly Asn Val Leu Pro Trp Glu Asp Lys Leu Val Glu Ala Phe Gly Gly
     460                 465                 470

 gca aca aag gct gcc ttc gat gtc tgc aag ggg agg gcc aag gca tga     1671
 Ala Thr Lys Ala Ala Phe Asp Val Cys Lys Gly Arg Ala Lys Ala 
 475                 480                 485

 ggggccacct catccagggc ccctcccttg cctgccactt tggggacttg aggggggtca   1731

 tattccctcc tcagcctgcc cacgcactgg ccttccctcc tgccccactc ctggctgtgc   1791

 ctcccatttc ccctcacctg tacccacacc tccagaatgc cctgccctgc gagtgtgtcc   1851

 cctgtcccca cctgagtggg gaggagcgtc tcaagtgaac agtgggagcc tgcccacctg   1911

 gcactgcact ggagttgtct cttaccccac cctccctgcc catcaactgt atctgatttc   1971

 actaattttg acagcacccc cagtagggta ggattgtgta tgagggggac cccactatct   2031

 cagtggtggg ggtggccgcc cgcccccttg tcccccatgc aacaggccca gtggcttccc   2091

 cttcagggcc acaacaggct gtagaagggg atgacgagga catcagaggt tagacttacc   2151

 ctcctccctc tttccaccag ctgccagtca agggcagtgg gatctcgatg gagcctcccc   2211

 cccccccacc catgcctccc tcttcctcct ctttcctcct ctctttgtgt gtagcggttt   2271

 gaatgttggt tccatgcctg gcccagcccc acctcagtct ccaggacatt cctttcccag   2331

 ctccagcctg gagggaaggg gacaaagacc ccaggaggcc aaagggctgc agtcacccct   2391

 tgtgctcacc catagtgatg gccactggta tagtcatcgc tctccctcca tgccaaggac   2451

 aggacttgga ccgcttcagc ctgggctggg agcagcccta aggtagaggc ctcatggccc   2511

 aggagacccc acctctggca gagccacatt acctaccctg tgcatggtcc tggggcagca   2571

 aggaagaagc tcagagggtg gggagaagca tgaagcagtg agcagagcac tgggtgagag   2631

 ggagaagacc ttggttccta gccagccctg ctaatgtgct gtgtggcctt ctgtaagtcc   2691

 ctgccctctc tgggcctggc cttcctcatt cgtgagctga ggccctcgct ttggtcattt   2751

 gctctccaga ttgggtgtga gcttctctgt gattccaggt ggatatgtgg ggaaagctct   2811

 ggtgaccctg ggcttcgcag gggtagatcc caggactcgg cagtggatgg gatgcagcca   2871

 gtcatgggtt agggtcagca gagactcaga gtccagggca aggttcaagg cagactaacc   2931

 tcatgcatgg attgtaaaaa accagctccc tttggatcaa cccagcctgg cacccttgcc   2991

 tgtctgagag tgtctcaaag ggctgatggc ttcctggtcc ccttgagtca tcaccagctt   3051

 ccccaagaga gtgtcagaa                                                3070




      <210> 288
      <211> 7397
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (185)..(2623)

      <400> 288
 cagtggtgca tcatgtctga aagaatggaa tacgaccagg cgggccgcat cacatccagg     60

 atcttcgctg atgggaagac atggagctac acatacttag agaagtccat ggtgctgcta    120

 ctacacagcc agaggcaagt atatctttga gttcgacaag aatgaccgcc tctcttctgt    180

 gacg atg ccc aac gtg gcg cgg cag aaa cta gag acc atc cgc tca gtg     229
      Met Pro Asn Val Ala Arg Gln Lys Leu Glu Thr Ile Arg Ser Val
        1               5                  10                  15

 ggc tac tac aga aac atc tat cag ccc cct gag ggc aat gcc tca gtc      277
 Gly Tyr Tyr Arg Asn Ile Tyr Gln Pro Pro Glu Gly Asn Ala Ser Val
                  20                  25                  30

 ata cag gac ttc act gag gat ggg cac ctc ctt cac acc ttc tac ctg      325
 Ile Gln Asp Phe Thr Glu Asp Gly His Leu Leu His Thr Phe Tyr Leu
              35                  40                  45

 ggc act ggc cgc agg gtg ata tac aag tat ggc aaa ctg tca aag ctg      373
 Gly Thr Gly Arg Arg Val Ile Tyr Lys Tyr Gly Lys Leu Ser Lys Leu
          50                  55                  60

 gca gag acg ctc tat gac acc acc aag gtc agt ttc acc tat gac gag      421
 Ala Glu Thr Leu Tyr Asp Thr Thr Lys Val Ser Phe Thr Tyr Asp Glu
      65                  70                  75

 acg gca ggc atg ctg aag acc atc aac cta cag aat gag ggc ttc acc      469
 Thr Ala Gly Met Leu Lys Thr Ile Asn Leu Gln Asn Glu Gly Phe Thr
  80                  85                  90                  95

 tgc acc atc cgc tac cgt cag att ggg ccc ctg att gac cga cag atc      517
 Cys Thr Ile Arg Tyr Arg Gln Ile Gly Pro Leu Ile Asp Arg Gln Ile
                 100                 105                 110

 ttc cgc ttc act gag gaa ggc atg gtc aac gcc cgt ttt gac tac aac      565
 Phe Arg Phe Thr Glu Glu Gly Met Val Asn Ala Arg Phe Asp Tyr Asn
             115                 120                 125

 tat gac aac agc ttc cgg gtg acc agc atg cag gct gtg atc aac gag      613
 Tyr Asp Asn Ser Phe Arg Val Thr Ser Met Gln Ala Val Ile Asn Glu
         130                 135                 140

 acc cca ctg ccc att gat ctc tat cgc tat gat gat gtg tca ggc aag      661
 Thr Pro Leu Pro Ile Asp Leu Tyr Arg Tyr Asp Asp Val Ser Gly Lys
     145                 150                 155

 aca gag cag ttt ggg aag ttt ggt gtc att tac tat gac att aac cag      709
 Thr Glu Gln Phe Gly Lys Phe Gly Val Ile Tyr Tyr Asp Ile Asn Gln
 160                 165                 170                 175

 atc atc acc aca cct gtc atg acc cac acc aag cat ttt gat gca tat      757
 Ile Ile Thr Thr Pro Val Met Thr His Thr Lys His Phe Asp Ala Tyr
                 180                 185                 190

 ggc agg atg aag gaa gtg cag tat gag atc ttc cgc tcg ctc atg tac      805
 Gly Arg Met Lys Glu Val Gln Tyr Glu Ile Phe Arg Ser Leu Met Tyr
             195                 200                 205

 tgg atg acc gtc cag tat gat aac atg ggg cga gta gtg aag aag gag      853
 Trp Met Thr Val Gln Tyr Asp Asn Met Gly Arg Val Val Lys Lys Glu
         210                 215                 220

 ctg aag gta gga ccc tac gcc aat acc act cgc tac tcc tat gag tat      901
 Leu Lys Val Gly Pro Tyr Ala Asn Thr Thr Arg Tyr Ser Tyr Glu Tyr
     225                 230                 235

 gat gct gac ggc cag ctg cag aca gtc tcc atc aat gac aag cca ctc      949
 Asp Ala Asp Gly Gln Leu Gln Thr Val Ser Ile Asn Asp Lys Pro Leu
 240                 245                 250                 255

 tgg cgc tac agc tac gac ctc aat ggg aac ctg cac tta ctg agc cct      997
 Trp Arg Tyr Ser Tyr Asp Leu Asn Gly Asn Leu His Leu Leu Ser Pro
                 260                 265                 270

 ggg aac agt gca cgg ctc aca cca cta cgg tat gac atc cgc gac cgc     1045
 Gly Asn Ser Ala Arg Leu Thr Pro Leu Arg Tyr Asp Ile Arg Asp Arg
             275                 280                 285

 atc act cgg ctg ggt gac gtg caa tac aag atg gat gag gat ggc ttc     1093
 Ile Thr Arg Leu Gly Asp Val Gln Tyr Lys Met Asp Glu Asp Gly Phe
         290                 295                 300

 ctg agg cag cgg ggc ggt gat atc ttt gag tac aac tca gct ggc ctg     1141
 Leu Arg Gln Arg Gly Gly Asp Ile Phe Glu Tyr Asn Ser Ala Gly Leu
     305                 310                 315

 ctc atc aag gcc tac aac cgg gct ggc agc tgg agt gtc agg tac cgc     1189
 Leu Ile Lys Ala Tyr Asn Arg Ala Gly Ser Trp Ser Val Arg Tyr Arg
 320                 325                 330                 335

 tac gat ggc ctg ggg cgg cgc gtg tcc agc aag agc agc cac agc cac     1237
 Tyr Asp Gly Leu Gly Arg Arg Val Ser Ser Lys Ser Ser His Ser His
                 340                 345                 350

 cac ctg cag ttc ttc tat gca gac ctg acc aac ccc acc aag gtc acc     1285
 His Leu Gln Phe Phe Tyr Ala Asp Leu Thr Asn Pro Thr Lys Val Thr
             355                 360                 365

 cac ctg tac aac cac tcc agc tct gag atc acc tcc ctc tac tac gac     1333
 His Leu Tyr Asn His Ser Ser Ser Glu Ile Thr Ser Leu Tyr Tyr Asp
         370                 375                 380

 ttg caa gga cac ctc ttt gcc atg gag ctg agc agt ggt gat gag ttt     1381
 Leu Gln Gly His Leu Phe Ala Met Glu Leu Ser Ser Gly Asp Glu Phe
     385                 390                 395

 tac ata gct tgt gac aac atc ggg acc cct ctt gct gtc ttt agt gga     1429
 Tyr Ile Ala Cys Asp Asn Ile Gly Thr Pro Leu Ala Val Phe Ser Gly
 400                 405                 410                 415

 aca ggt ttg atg atc aag caa atc ctg tac aca gcc tat ggg gag atc     1477
 Thr Gly Leu Met Ile Lys Gln Ile Leu Tyr Thr Ala Tyr Gly Glu Ile
                 420                 425                 430

 tac atg gat acc aac ccc aac ttt caa atc atc ata ggc tac cat ggt     1525
 Tyr Met Asp Thr Asn Pro Asn Phe Gln Ile Ile Ile Gly Tyr His Gly
             435                 440                 445

 ggc ctc tat gat cca ctc acc aag ctt gtc cac atg ggc cgg cga gat     1573
 Gly Leu Tyr Asp Pro Leu Thr Lys Leu Val His Met Gly Arg Arg Asp
         450                 455                 460

 tat gat gtg ctg gcc gga cgc tgg act agc cca gac cac gag ctg tgg     1621
 Tyr Asp Val Leu Ala Gly Arg Trp Thr Ser Pro Asp His Glu Leu Trp
     465                 470                 475

 aag cac ctt agt agc agc aac gtc atg cct ttt aat ctc tat atg ttc     1669
 Lys His Leu Ser Ser Ser Asn Val Met Pro Phe Asn Leu Tyr Met Phe
 480                 485                 490                 495

 aaa aac aac aac ccc atc agc aac tcc cag gac atc aag tgc ttc atg     1717
 Lys Asn Asn Asn Pro Ile Ser Asn Ser Gln Asp Ile Lys Cys Phe Met
                 500                 505                 510

 aca gat gtt aac agc tgg ctg ctc acc ttt gga ttc cag cta cac aac     1765
 Thr Asp Val Asn Ser Trp Leu Leu Thr Phe Gly Phe Gln Leu His Asn
             515                 520                 525

 gtg atc cct ggt tat ccc aaa cca gac atg gat gcc atg gaa ccc tcc     1813
 Val Ile Pro Gly Tyr Pro Lys Pro Asp Met Asp Ala Met Glu Pro Ser
         530                 535                 540

 tac gag ctt atc cac aca cag atg aaa acg cag gag tgg gac aac agc     1861
 Tyr Glu Leu Ile His Thr Gln Met Lys Thr Gln Glu Trp Asp Asn Ser
     545                 550                 555

 aag tct atc ctc ggg gta cag tgt gaa gta cag aag cag ctc aag gcc     1909
 Lys Ser Ile Leu Gly Val Gln Cys Glu Val Gln Lys Gln Leu Lys Ala
 560                 565                 570                 575

 ttt gtc acc tta gaa cgg ttt gac cag ctc tat ggc tcc aca atc acc     1957
 Phe Val Thr Leu Glu Arg Phe Asp Gln Leu Tyr Gly Ser Thr Ile Thr
                 580                 585                 590

 agc tgc ctg cag gct cca aag acc aag aag ttt gca tcc agc ggc tca     2005
 Ser Cys Leu Gln Ala Pro Lys Thr Lys Lys Phe Ala Ser Ser Gly Ser
             595                 600                 605

 gtc ttt ggc aag ggg gtc aag ttt gcc ttg aag gat ggc cga gtg acc     2053
 Val Phe Gly Lys Gly Val Lys Phe Ala Leu Lys Asp Gly Arg Val Thr
         610                 615                 620

 aca gac atc atc agt gtg gcc aat gag gat ggg cga agg gtt gct gcc     2101
 Thr Asp Ile Ile Ser Val Ala Asn Glu Asp Gly Arg Arg Val Ala Ala
     625                 630                 635

 atc ttg aac cat gcc cac tac cta gag aac ctg cac ttc acc att gat     2149
 Ile Leu Asn His Ala His Tyr Leu Glu Asn Leu His Phe Thr Ile Asp
 640                 645                 650                 655

 ggg gtg gat acc cat tac ttt gtg aaa cca gga cct tca gaa ggt gac     2197
 Gly Val Asp Thr His Tyr Phe Val Lys Pro Gly Pro Ser Glu Gly Asp
                 660                 665                 670

 ctg gcc atc ctg ggc ctc agt ggg ggg cgg cga acc ctg gag aat ggg     2245
 Leu Ala Ile Leu Gly Leu Ser Gly Gly Arg Arg Thr Leu Glu Asn Gly
             675                 680                 685

 gtc aac gtc act gtg tcc cag atc aac aca gta ctt agt ggc agg act     2293
 Val Asn Val Thr Val Ser Gln Ile Asn Thr Val Leu Ser Gly Arg Thr
         690                 695                 700

 aga cgc tac aca gac atc cag ctc cag tac ggg gca ctg tgc ttg aac     2341
 Arg Arg Tyr Thr Asp Ile Gln Leu Gln Tyr Gly Ala Leu Cys Leu Asn
     705                 710                 715

 aca cgc tac ggg aca acg ttg gat gag gag aag gca cgg gtc ctg gag     2389
 Thr Arg Tyr Gly Thr Thr Leu Asp Glu Glu Lys Ala Arg Val Leu Glu
 720                 725                 730                 735

 ctg gcc cgg cag aga gcc gtg cgc caa gcg tgg gcc cgc gag cag cag     2437
 Leu Ala Arg Gln Arg Ala Val Arg Gln Ala Trp Ala Arg Glu Gln Gln
                 740                 745                 750

 aga ctg cgg gaa ggg gag gaa ggc ctg cgg gcc tgg aca gag ggg gag     2485
 Arg Leu Arg Glu Gly Glu Glu Gly Leu Arg Ala Trp Thr Glu Gly Glu
             755                 760                 765

 aag cag cag gtg ctg agc aca ggg cgg gtg caa ggc tac gac ggc ttt     2533
 Lys Gln Gln Val Leu Ser Thr Gly Arg Val Gln Gly Tyr Asp Gly Phe
         770                 775                 780

 ttc gtg atc tct gtc gag cag tac cca gaa ctg tca gac agc gcc aac     2581
 Phe Val Ile Ser Val Glu Gln Tyr Pro Glu Leu Ser Asp Ser Ala Asn
     785                 790                 795

 aac atc cac ttc atg aga cag agc gag atg ggc cgg agg tga cagagag     2630
 Asn Ile His Phe Met Arg Gln Ser Glu Met Gly Arg Arg 
 800                 805                 810

 gaccaaggac ttcttgccaa agacagctac tcttttgtgg ccgcatacct gactgtgttg   2690

 tacttttaaa aaaatgattt tttaacaagt gcagaaacaa aaagatactg gttgcattgt   2750

 aactcatgca acatcctttt ttttagaaaa gaaaaacaca gatttggcct tcgcacattt   2810

 tttgcaaaga acagaaggta tttttttctg tagtgtgatc acaatgaaaa ctttattgtc   2870

 ttttgttccc tttttccttg aggatttttc ccttgtcgtt tggggtatgt atctcctctc   2930

 tgagatgcat ctcctggggt gtgtcctcgt ctgtccctag gtacccagtg tgatgtggga   2990

 catgaatgtc tgtgctaact tgtctcatgt gcaacccttt cttcttcgac tggggtcggg   3050

 caggagtaaa gggagtgatg ggccagtaca acaccccttc caagggggcc tgggaggagg   3110

 gtctgtagga cctgaggctc cttggcaggg ctcctgcaga agagtggtgg atttcttctc   3170

 accttgttct ctgcctccag aggatcatag atggcttcat cttgctccag ggaatttcat   3230

 ggtgttgttc agcacctttt ttaagctgcc ccaaactcct gttcaagctt tctattttga   3290

 tgctgaatga aaccccctac cacttttgca aatcctgtgt agttgtcggt gccaccccca   3350

 tgctgggata gagaaagtgt ctcccaggtc ctttccccca gaccagtgac ataacatcct   3410

 gggctcagag tcccatcctc ccgggaggga aagcacccag gatgcctgtg attggttggt   3470

 cctccatgat gttcctgttc atctcctcct ttctcccaaa gccagatgtg agaacgagca   3530

 ctgcacagca agccttcaat gtgggcacca tgtccacaga acagaaggcc acccatggca   3590

 aaggcatggc agtggtggcg agggcaccag cctgccttcc gaggcaaagc cctctctcta   3650

 tgactttgag tatcttccct ccaccactca gccgccacca ctgagacgta ggaatgtgga   3710

 gggaggtgct tggtggcctt tgattctgga aaaatgctta acaaaaaaag ccagccaaag   3770

 agaggaaggc ataagctaag catccttcta accagttccc aaagtcccat ctgcctccat   3830

 gtaccagctg atcgcagagc tggactgggg caggctgggc ttccaggaaa ttcctgaagt   3890

 tctgaaacag cttcccctct agagaagccc acccaatgtg ttttttagtg acaggaagaa   3950

 aggagggaag agctgatgtg gtgtggcctg cccatatcat acaaccccac caggagcagg   4010

 gcagttccca aggtgggtgc ccgtagatct gggaggccag gctggcatga ttcctgtgaa   4070

 gaactgtgcc tgtgtcgtca gggagaggcc tgagccctct cagaagcagg gacagcccac   4130

 acctgaagag cacgcccaag ctgaggcagc agccagcagg ctgggggagc agtgagggca   4190

 gggggagtca cagccagagc tgggagcccc ttgttcaagg attccattcc tggttcatcc   4250

 gcctaattac cattgtcatt accactcaca ggaggctctg ggagatggga ggggaagcca   4310

 aatgcttcct tttaagctgg gcttcttaga aaatggaact tttatgggtt acatttacat   4370

 taagtgtgga aaatgaattc tgagtctgag ctattccccg tggaaacctt gttggactga   4430

 taagctcatg gcacctctat agccttactc acatagtctt cagaatatta cacaagttaa   4490

 tgaaactgag aaggtctgac tgcatgagga tcggagcagc atgtagtctg ggttctgcct   4550

 ggcagaggga ggcaaccaaa acttcttggg gagaagagat ttcgccttaa cgtcatccca   4610

 ctgggattag aggatgtgtt tcgctaagtg ctcttcctgt ttccaaaaaa aaagccaccc   4670

 tgctgcagca gtgcgctttg gcctgcttgt ccactggttg cccattgccc ctggatccag   4730

 agctctactg agtcagatac agtgctctgc aggcctgctg tgggaggcat gagctggaga   4790

 tgggggctcc catctggcag gatcattctt ggatgagatg gaaaacagtt tggcctgaag   4850

 aacacaagtt ttgtcctcca gaagggactt acgcctctca aaatgtactc ttcataccaa   4910

 gggcccttgg gcaaagtgct cctgcccagt tgatcagtcc catcctggct gcctgacatc   4970

 agtgaagacc tgctggggat gtctgctcag aggtcaggaa cggcatgcgg tccacaggaa   5030

 ccagctccct acgcttcccc cacgccctgt ccctcctcca cagccccctc cccaaaggaa   5090

 tagggtggac ttttagggat caaaaacaga attattgggt gtttcatttc tttttttctt   5150

 tctttctttt ttttttcata gagatggggt ctcactatgt tgcccaggct gttctcaaac   5210

 tcctggcctc aggcgatcca ccttggcctc ctgaagtgct ggggttacag gtgtgagcca   5270

 ctgcgcctgg actgagtgtt tgtttcttta aaggatctta tatttttcct gtgctacata   5330

 ccaccacagc agcccagctt ctgtggggag agaagttgaa ggatcccgaa gctttagaaa   5390

 aaggatctca gctgtggcac aggcagtgtt atgcgcctca ctgccacatt ggtgctgttg   5450

 tattgaaggt ggtgcttctg gccttggccc ttttgagttg gtttccattt gggctgcagg   5510

 tgactcagtg actccctcct caagctgtcc tcctgctaag accagcagtc acaaacccat   5570

 ggcaagggtg agtgtgaagg cctaaccctg tgcctatgta ataggctcca agcatcgact   5630

 cccatcctga gaggaccggc ccttttgaca ctcaccaacc aaatctgttc attcgataga   5690

 gtgaccaggc ctccctcacc tgcccaggtg tatgatccta cagttcctgc cttctctcct   5750

 accccgcaca gctgccaact ggtcctacat cctcagcccc tctgccacca ccttaaatag   5810

 gactttactg attccccaac tttgtttttt tgtaggatga gatttccttt ttatcccacc   5870

 cccccacacc ccaaacagac attgctggag ggcagactgg aggaagggga aggcatgcag   5930

 gtaaattact gccttgtcag cctctgaccc tcatctctca gaattgttgg ctgagaatta   5990

 acccaaggac cacaccagtg cctgatttct acttagggag agaggattgg aaacgatccc   6050

 taagaaactg actgagggtg agaatggcca ggaggtgtgt gtccaaataa ccaggagggg   6110

 gcacagaaga tgatggcaag gcagactggg cagtgttttg tagacacaga acaaagaatc   6170

 agaatttgaa aaaagaagaa aaacaaatct tcgcagctgc aactttaaag tatcaccttt   6230

 atagatggca gggatttcca ttatgcaaat ggaatctaag atttcaatgt gaaatcttag   6290

 aatgcagttt taccacttgc agtcttgtat ttgtggtggc catgtggtga gggcggtgat   6350

 gctgagcttt ctgcccagga ggaatgagct ttcaagctct cagcagggtg tcagacttgg   6410

 ggatttgagc atccactgct caaagtccag gctattctcc agtcctcacg gcagccacta   6470

 agcccaggag ccagacctgg cccggggaca catctcctga gggatcccag aaagaaccca   6530

 gtctttcctt tcccttgggg tccttgttag aatgaaaacc tctctattta aggcacatca   6590

 ttcccagcta ggtttataca cttgtctata ttttactgga ggaaagggaa ttaaaaaaga   6650

 actctgcagt tcaaggccct ttcatttaac cttccaaaaa cagcaaactc attttaaaga   6710

 ctcattgctg aggtgataga gagaaacctt atcctctcca acctttacat tcacaaaaac   6770

 catccttgtg tacttgactg ccctagacag tggtgactct taggtttcat tacgaatgtg   6830

 gaatatcaga gtgtgggaag gcccaggaga gggccaatgt tgtgtttctt accccctctg   6890

 gaatgccaaa ggcaaggtac taggtgacct cctggtcccc aagaaaatgt gatttattct   6950

 gagggcgaac agccaaggga ggactagtct ggagcacgct cggccgtcct ggcaggagct   7010

 gagcctcagg tgtctggtgg tgccccagca gccctggatt cacccaacac cagaatccca   7070

 cttttctaaa tccacctgtt gttctgagca cctctgaacc cgcagcttcg gcaaaaggag   7130

 tctgtaccaa gctgcttctg gatgaccaac actggagact ctggccttac catgtggaaa   7190

 tcattttcct gaagtctgga actaattttg agaagttttt ttctcaacac ttttgtgttt   7250

 ctaacactgt atcttgactg tgtaaatacc aacaaggctg taaataaatg cagatgtaga   7310

 taccttctag aaaaaaaaaa gcataaaaac aaaaccagaa gtgatcccgt gtagccttcg   7370

 ttgacaaata aagactattt tgtgttt                                       7397




      <210> 289
      <211> 4992
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (929)..(3157)

      <400> 289
 ggtatctgta cgtcttcgaa cctccgactt tcgttcttga ttaatgaaaa cattcttggc     60

 aaatgctttc gctctggtcc gtcttgcgcc ggtccaagaa tttcacctct agcggcgcaa    120

 tacgaatgcc cccggccgtc cctcttaatc atggcctcag ttccgaaaac caacaaaata    180

 gaaccgcggt cctattccat tattcctagc tgcggtatcc aggcggctcg ggcctgcttt    240

 gaacactcta attttttcaa agtaaacgtt cgggccccgc gggacactca gctaagagca    300

 tcgagggggc gccgagaggc aaggccgagc tctaggccgg ccggcggtgg cggcggcgag    360

 gccgggactc gggcttaggg cctgctgtgg aggcagcggc ggacgccgag ctaagcagtt    420

 tctctggaaa cccccctggt aagtgtggag gaggcgggac actctgaccc aagacgaaag    480

 gcctgtagct ccagccaaag aaaataaacc ttaggaggga gaaggaaaaa aaaatccatc    540

 agctgttcct gagaacagcc tgcattggaa tctacagaga ggacaactaa tgtgagtgag    600

 gaagtgactg tatgtggact gtggagaaag taagtcacgt gggcccttga ggacctggac    660

 tgggttagga acagttgtac tttcagaggt gaggtgtcga gaagggaaag tgaatgtggt    720

 ctggagtgtg tccttggcct tggctccaca gggtgtgctt tcctctgggg ccgtcaggga    780

 gctcatccct tgtgttctgc cagggtgggg tacggggttt gacactgagg agggtaacct    840

 gctggctgga gcggcagagc agtggccttg atttgtcttt tggaagattt taaaaaccaa    900

 aaagcataaa cattctggtc cttcagca   atg ctt tct ctg aag aaa tac tta     952
                                  Met Leu Ser Leu Lys Lys Tyr Leu
                                    1               5

 acg gaa gga ctt ctc cag ttc acc att ctg ctg agt ttg att ggg gta     1000
 Thr Glu Gly Leu Leu Gln Phe Thr Ile Leu Leu Ser Leu Ile Gly Val
      10                  15                  20

 cgg gtg gac gtg gat act tac ctg acc tca cag ctt ccc cca ctc cgg     1048
 Arg Val Asp Val Asp Thr Tyr Leu Thr Ser Gln Leu Pro Pro Leu Arg
  25                  30                  35                  40

 gag atc atc ctg ggg ccc agt tct gcc tat act cag acc cag ttc cac     1096
 Glu Ile Ile Leu Gly Pro Ser Ser Ala Tyr Thr Gln Thr Gln Phe His
                  45                  50                  55

 aac ctg agg aat acc ttg gat ggc tat ggt atc cac ccc aag agc ata     1144
 Asn Leu Arg Asn Thr Leu Asp Gly Tyr Gly Ile His Pro Lys Ser Ile
              60                  65                  70

 gac ctg gac aat tac ttc act gcc cgg cgg ctc ctc agt cag gtg agg     1192
 Asp Leu Asp Asn Tyr Phe Thr Ala Arg Arg Leu Leu Ser Gln Val Arg
          75                  80                  85

 gcc ctg gac agg ttc cag gtg cca acc act gag gta aat gcc tgg ctg     1240
 Ala Leu Asp Arg Phe Gln Val Pro Thr Thr Glu Val Asn Ala Trp Leu
      90                  95                 100

 gtt cac cga gac cca gag ggg tct gtc tct ggc agt cag ccc aac tca     1288
 Val His Arg Asp Pro Glu Gly Ser Val Ser Gly Ser Gln Pro Asn Ser
 105                 110                 115                 120

 ggc ctc gcc ctc gag agt tcc agt ggc ctc caa gat gtg aca ggc cca     1336
 Gly Leu Ala Leu Glu Ser Ser Ser Gly Leu Gln Asp Val Thr Gly Pro
                 125                 130                 135

 gac aac ggg gtg cga gaa agc gaa acg gag cag gga ttc ggt gaa gat     1384
 Asp Asn Gly Val Arg Glu Ser Glu Thr Glu Gln Gly Phe Gly Glu Asp
             140                 145                 150

 ttg gag gat ttg ggg gct gta gcc ccc cca gtc agt gga gac tta acc     1432
 Leu Glu Asp Leu Gly Ala Val Ala Pro Pro Val Ser Gly Asp Leu Thr
         155                 160                 165

 aaa gag gac ata gat ctg att gac atc ctt tgg cga cag gat att gat     1480
 Lys Glu Asp Ile Asp Leu Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp
     170                 175                 180

 ctg ggg gct ggg cgt gag gtt ttt gac tat agt cac cgc cag aag gag     1528
 Leu Gly Ala Gly Arg Glu Val Phe Asp Tyr Ser His Arg Gln Lys Glu
 185                 190                 195                 200

 cag gat gtg gag aag gag ctg cga gat gga ggc gag cag gac acc tgg     1576
 Gln Asp Val Glu Lys Glu Leu Arg Asp Gly Gly Glu Gln Asp Thr Trp
                 205                 210                 215

 gca ggc gag ggc gcg gaa gct ctg gca cgg aac ctg cta gtg gat gga     1624
 Ala Gly Glu Gly Ala Glu Ala Leu Ala Arg Asn Leu Leu Val Asp Gly
             220                 225                 230

 gag act ggg gag agc ttc cct gca cag ttt cca gca gac att tcc agc     1672
 Glu Thr Gly Glu Ser Phe Pro Ala Gln Phe Pro Ala Asp Ile Ser Ser
         235                 240                 245

 ata aca gaa gca gtg cct agt gag agt gag ccc cct gct ctt caa aac     1720
 Ile Thr Glu Ala Val Pro Ser Glu Ser Glu Pro Pro Ala Leu Gln Asn
     250                 255                 260

 aac ctc ttg tct cct ctt ctg acc ggg aca gag tca cca ttt gat ttg     1768
 Asn Leu Leu Ser Pro Leu Leu Thr Gly Thr Glu Ser Pro Phe Asp Leu
 265                 270                 275                 280

 gaa cag cag tgg caa gat ctc atg tcc atc atg gaa atg cag gcc atg     1816
 Glu Gln Gln Trp Gln Asp Leu Met Ser Ile Met Glu Met Gln Ala Met
                 285                 290                 295

 gaa gtg aac aca tca gca agt gaa atc ctg tac agt gcc cct cct gga     1864
 Glu Val Asn Thr Ser Ala Ser Glu Ile Leu Tyr Ser Ala Pro Pro Gly
             300                 305                 310

 gac cca ctg agc acc aac tac agc ctt gcc ccc aac act ccc atc aat     1912
 Asp Pro Leu Ser Thr Asn Tyr Ser Leu Ala Pro Asn Thr Pro Ile Asn
         315                 320                 325

 cag aat gtc agc ctg cat cag gcg tcc ctg ggg ggc tgc agc cag gac     1960
 Gln Asn Val Ser Leu His Gln Ala Ser Leu Gly Gly Cys Ser Gln Asp
     330                 335                 340

 ttc tta ctc ttc agc ccc gag gtg gaa agc ctg cct gtg gcc agt agc     2008
 Phe Leu Leu Phe Ser Pro Glu Val Glu Ser Leu Pro Val Ala Ser Ser
 345                 350                 355                 360

 tcc acg ctg ctc ccg ttg gcc ccc agc aat tct acc agc ctc aac tcc     2056
 Ser Thr Leu Leu Pro Leu Ala Pro Ser Asn Ser Thr Ser Leu Asn Ser
                 365                 370                 375

 acc ttc ggc tcc acc aac ctg aca ggg ctc ttc ttt cca ccc cag ctc     2104
 Thr Phe Gly Ser Thr Asn Leu Thr Gly Leu Phe Phe Pro Pro Gln Leu
             380                 385                 390

 aat ggc aca gcc aat gac aca gca ggc cca gag ctg cct gac cct ttg     2152
 Asn Gly Thr Ala Asn Asp Thr Ala Gly Pro Glu Leu Pro Asp Pro Leu
         395                 400                 405

 ggg ggt ctg tta gat gaa gct atg ttg gat gag atc agc ctt atg gac     2200
 Gly Gly Leu Leu Asp Glu Ala Met Leu Asp Glu Ile Ser Leu Met Asp
     410                 415                 420

 ctg gcc att gaa gaa ggc ttt aac cct gtg cag gcc tcc cag ctg gag     2248
 Leu Ala Ile Glu Glu Gly Phe Asn Pro Val Gln Ala Ser Gln Leu Glu
 425                 430                 435                 440

 gag gaa ttt gac tct gac tca ggc ctt tcc tta gac tcg agc cat agc     2296
 Glu Glu Phe Asp Ser Asp Ser Gly Leu Ser Leu Asp Ser Ser His Ser
                 445                 450                 455

 cct tct tcc cta agc agc tct gaa ggc agt tct tcc tct tct tcc tcc     2344
 Pro Ser Ser Leu Ser Ser Ser Glu Gly Ser Ser Ser Ser Ser Ser Ser
             460                 465                 470

 tcc tct tcc tct tct tcc tct gct tct tcc tct gcc tct tcc tcc ttt     2392
 Ser Ser Ser Ser Ser Ser Ser Ala Ser Ser Ser Ala Ser Ser Ser Phe
         475                 480                 485

 tct gag gaa ggt gcg gtt ggc tac agc tct gac tct gag acc ctg gat     2440
 Ser Glu Glu Gly Ala Val Gly Tyr Ser Ser Asp Ser Glu Thr Leu Asp
     490                 495                 500

 ctg gaa gag gcc gag ggt gct gtg ggc tac cag cct gag tat tcc aag     2488
 Leu Glu Glu Ala Glu Gly Ala Val Gly Tyr Gln Pro Glu Tyr Ser Lys
 505                 510                 515                 520

 ttc tgc cgc atg agc tac cag gat cca gct cag ctc tca tgc ctg ccc     2536
 Phe Cys Arg Met Ser Tyr Gln Asp Pro Ala Gln Leu Ser Cys Leu Pro
                 525                 530                 535

 tac ctg gag cac gtg ggc cac aac cac aca tac aac atg gca ccc agt     2584
 Tyr Leu Glu His Val Gly His Asn His Thr Tyr Asn Met Ala Pro Ser
             540                 545                 550

 gcc ctg gac tca gcc gac ctg cca cca ccc agt gcc ctc aag aaa ggc     2632
 Ala Leu Asp Ser Ala Asp Leu Pro Pro Pro Ser Ala Leu Lys Lys Gly
         555                 560                 565

 agc aag gag aag cag gct gac ttc ctg gac aag cag atg agc cgg gat     2680
 Ser Lys Glu Lys Gln Ala Asp Phe Leu Asp Lys Gln Met Ser Arg Asp
     570                 575                 580

 gag cac cga gcc cga gcc atg aag atc cct ttc acc aat gac aaa atc     2728
 Glu His Arg Ala Arg Ala Met Lys Ile Pro Phe Thr Asn Asp Lys Ile
 585                 590                 595                 600

 atc aac ctg cct gtg gag gag ttc aat gaa ctg ctg tcc aaa tac cag     2776
 Ile Asn Leu Pro Val Glu Glu Phe Asn Glu Leu Leu Ser Lys Tyr Gln
                 605                 610                 615

 ttg agt gaa gcc cag ctg agc ctc atc cga gac atc cgg cgc cgg ggc     2824
 Leu Ser Glu Ala Gln Leu Ser Leu Ile Arg Asp Ile Arg Arg Arg Gly
             620                 625                 630

 aag aac aag atg gcg gcg cag aac tgc cgc aag cgc aag ctg gac acc     2872
 Lys Asn Lys Met Ala Ala Gln Asn Cys Arg Lys Arg Lys Leu Asp Thr
         635                 640                 645

 atc ctg aat ctg gag cgt gat gtg gag gac ctg cag cgt gac aaa gcc     2920
 Ile Leu Asn Leu Glu Arg Asp Val Glu Asp Leu Gln Arg Asp Lys Ala
     650                 655                 660

 cgg ctg ctg cgg gag aaa gtg gag ttc ctg cgc tcc ctg cga cag atg     2968
 Arg Leu Leu Arg Glu Lys Val Glu Phe Leu Arg Ser Leu Arg Gln Met
 665                 670                 675                 680

 aag cag aag gtc cag agc ctg tac cag gag gtg ttt ggg cgg ctg cga     3016
 Lys Gln Lys Val Gln Ser Leu Tyr Gln Glu Val Phe Gly Arg Leu Arg
                 685                 690                 695

 gat gag aac gga cga ccc tac tcg ccc agt cag tat gcg ctc cag tac     3064
 Asp Glu Asn Gly Arg Pro Tyr Ser Pro Ser Gln Tyr Ala Leu Gln Tyr
             700                 705                 710

 gcc ggg gac ggc agt gtc ctc ctc atc ccc cgc acg atg gcc gac cag     3112
 Ala Gly Asp Gly Ser Val Leu Leu Ile Pro Arg Thr Met Ala Asp Gln
         715                 720                 725

 cag gcc cgg cgg cag gag agg aag cca aag gac cgg aga aag tga gcc     3160
 Gln Ala Arg Arg Gln Glu Arg Lys Pro Lys Asp Arg Arg Lys 
     730                 735                 740

 tggggaagaa gggggtttga agcccaccaa gaccgaaact ggagaagggc tggacctgga   3220

 cctggacctg gacctacagc ggggacttaa atgccttctt atccaatata tcttctcaga   3280

 tgggatgact gcgggtcagt gtacaggaag aggcaggcac tggctggctc agctccactc   3340

 gggtggagtg gaagtggcca gaccatttag acggacaggg tcctcaccct acccctttcc   3400

 tgtgaggcag gggtggtggt ggagttgctg gaggtagagg agctatgtgg agcaaaggcc   3460

 gacagagggg aaggaatgga cctgtgagag gaagggaagg tggcagaaag tctcatttca   3520

 ggaaggaggg atagaaggaa ggaaggaagg aacccccccc cccccgaaaa aaaaatcaaa   3580

 gcgggaagaa aatcagaggg aaggttaagg ttggctctgg ccaggattcc aggcagcagg   3640

 ttggagtgac tggtgggcct agatcactgg tgtgataaac cccatttcac cccggggggg   3700

 gtggggtaca cagacacagg gtgggggtgg ggaggggcgg tgttaactct ttctgctcct   3760

 tgcattttga catccctgaa ggggagctct tggatatcat tggccatgtt tcaatcgaat   3820

 ggagccactg ggccccaaca ctggctttga gatttagagt caaagggtag agtgaacagg   3880

 aaagggtcac gtggtcccat gttgcaacag ccccaacata cgcatgtcat tcactgcctt   3940

 gccactccat ctccctccgt gctccagcca cccctgagct gaggctccca ttgtctccat   4000

 cagagcctgc atgtgtatgc cgtcctcccc tggtccggtg tttgtgttcc ccacccctca   4060

 cagactgcct gagctcttct gtaagctggg gtagggtgat ggcagtgctc cgggaactgg   4120

 gcctgcagcc ttcctcttct gggactgctg tgaggcagag gaatgatgga gaatctagtg   4180

 tagcagcctc caggcaggat tcagcacaac actggggagt cacccttccc tcgggcctct   4240

 gcctaccaac aactgggctt atcactggga aaacacaaaa aattacacaa cccagcaaca   4300

 acaaaagaac tagtcctctt agaatttctt gcgctttgat ttttttaggg cttgtgccct   4360

 gtttcactta tagggtctag aatgcttgtg ttgagtaaaa aggagatgcc caatattcaa   4420

 agctgctaaa tgttctcttt gccataaaga ctccgtgtaa ctgtgtgaac acttgggatt   4480

 tttctcctct gtcccgaggt cgtcgtctgc tttctttttt gggtttcttt ctagaagatt   4540

 gagaagtgca tatgacaggc tgagagcacc tccccaaaca cacaagctct cagccacagg   4600

 cagcttctcc acagccccag cttcgcacag gctcctggag ggctgcctgg gggaggcaga   4660

 catgggagtg ccaaggtggc cagatggttc caggactaca atgtctttat ttttaactgt   4720

 ttgccactgc tgccctcacc cctgcccggc tctggagtac cgtctgcccc agacaagtgg   4780

 gagtgaaatg ggggtggggg gaagcactga ttcccagtta gggggtgcct aactgagcag   4840

 tagggataga aggtgtgaac ctgggagtgc ttttataaat tattttcctt gtagatttta   4900

 tttttaattt atctctgtga cctgccaggg agaggggaga gagagagaga tgctgttgag   4960

 cacatgacaa aataaaataa aatggatgat tc                                 4992




      <210> 290
      <211> 5313
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (200)..(5248)

      <400> 290
 atttggccct cgaggccaag aattcggcac gagactaaaa ttgccatagg acagactgac     60

 aacatcatct atgtctacaa gattggagaa gattggggtg acaagaaagt catctgcaac    120

 aagttcatcc agacggtaaa gttcagacca gtccctggaa ccttaggatg aacaaacata    180

 gtatggcagg aagagctat atg gtg aag ggc atg gct ttt tct cct gat tcc     232
                      Met Val Lys Gly Met Ala Phe Ser Pro Asp Ser
                        1               5                  10

 act aaa att gcc ata gga cag act gac aac atc atc tat gtc tac aag      280
 Thr Lys Ile Ala Ile Gly Gln Thr Asp Asn Ile Ile Tyr Val Tyr Lys
              15                  20                  25

 att gga gaa gat tgc ggt gac aag aaa gtc atc tgc aac aag ttc atc      328
 Ile Gly Glu Asp Cys Gly Asp Lys Lys Val Ile Cys Asn Lys Phe Ile
          30                  35                  40

 cat acg agt gct gtc act tgt ctg caa tgg ccg gca gaa tac atc att      376
 His Thr Ser Ala Val Thr Cys Leu Gln Trp Pro Ala Glu Tyr Ile Ile
      45                  50                  55

 gtc ttt gga ctg gct gaa ggg aag gtt cgt tta gca aac acc aaa act      424
 Val Phe Gly Leu Ala Glu Gly Lys Val Arg Leu Ala Asn Thr Lys Thr
  60                  65                  70                  75

 aat aaa tca tct acc atc tat ggg aca gag tct tac gtg gtg tcc ctg      472
 Asn Lys Ser Ser Thr Ile Tyr Gly Thr Glu Ser Tyr Val Val Ser Leu
                  80                  85                  90

 aca aca aat tgc tct ggg aaa gga att ctc tct ggt cat gca gat ggt      520
 Thr Thr Asn Cys Ser Gly Lys Gly Ile Leu Ser Gly His Ala Asp Gly
              95                 100                 105

 acc atc gtt agg tat ttc ttt gat gat gaa ggc tct gga gag tca cag      568
 Thr Ile Val Arg Tyr Phe Phe Asp Asp Glu Gly Ser Gly Glu Ser Gln
         110                 115                 120

 gag aag ttg gtt aac cac ccg tgt cca ccc tat gcc ttg gca tgg gca      616
 Glu Lys Leu Val Asn His Pro Cys Pro Pro Tyr Ala Leu Ala Trp Ala
     125                 130                 135

 acc aat agc atc gtg gct gca ggc tgt gat cgg aaa att gta gcc tat      664
 Thr Asn Ser Ile Val Ala Ala Gly Cys Asp Arg Lys Ile Val Ala Tyr
 140                 145                 150                 155

 gga aaa gaa ggt cac atg cta caa act ttt gat tat agc cgt gac cct      712
 Gly Lys Glu Gly His Met Leu Gln Thr Phe Asp Tyr Ser Arg Asp Pro
                 160                 165                 170

 cag gag cgg gag ttc acc aca gct gta tca agt cct ggg ggc cag tct      760
 Gln Glu Arg Glu Phe Thr Thr Ala Val Ser Ser Pro Gly Gly Gln Ser
             175                 180                 185

 gtt gtg cta gga agt tat gac agg ctt cgg gtg ttc aac tgg atc cct      808
 Val Val Leu Gly Ser Tyr Asp Arg Leu Arg Val Phe Asn Trp Ile Pro
         190                 195                 200

 cga aga agc atc tgg gaa gag gca aag ccc aag gag att acc aat tta      856
 Arg Arg Ser Ile Trp Glu Glu Ala Lys Pro Lys Glu Ile Thr Asn Leu
     205                 210                 215

 tac acc atc act gcc ttg gcc tgg aag cgg gat ggc tca cgg ctc tgt      904
 Tyr Thr Ile Thr Ala Leu Ala Trp Lys Arg Asp Gly Ser Arg Leu Cys
 220                 225                 230                 235

 gtg ggc aca cta tgt ggt ggg gtg gaa cag ttt gac tgc tgc ctc cga      952
 Val Gly Thr Leu Cys Gly Gly Val Glu Gln Phe Asp Cys Cys Leu Arg
                 240                 245                 250

 agg agt att tac aag aac aag ttt gag ttg acg tat gtg gga cct agc     1000
 Arg Ser Ile Tyr Lys Asn Lys Phe Glu Leu Thr Tyr Val Gly Pro Ser
             255                 260                 265

 cag gtg att gtg aag aac ctg tca tca gga acc cga gtg gtg ctc aag     1048
 Gln Val Ile Val Lys Asn Leu Ser Ser Gly Thr Arg Val Val Leu Lys
         270                 275                 280

 tca cac tat ggc tat gag gtg gaa gag gtg aaa atc cta gga aag gaa     1096
 Ser His Tyr Gly Tyr Glu Val Glu Glu Val Lys Ile Leu Gly Lys Glu
     285                 290                 295

 cgt tac ttg gtg gct cac aca tca gaa aca ctg ctg ctg ggg gac ctg     1144
 Arg Tyr Leu Val Ala His Thr Ser Glu Thr Leu Leu Leu Gly Asp Leu
 300                 305                 310                 315

 aac act aat cgg ctt agt gag ata gcc tgg caa gga tct ggt ggc aat     1192
 Asn Thr Asn Arg Leu Ser Glu Ile Ala Trp Gln Gly Ser Gly Gly Asn
                 320                 325                 330

 gag aag tat ttc ttt gaa aat gag aat gta tgc atg atc ttc aat gcc     1240
 Glu Lys Tyr Phe Phe Glu Asn Glu Asn Val Cys Met Ile Phe Asn Ala
             335                 340                 345

 gga gag cta acc ctg gtg gaa tat ggg aat aat gac acc ctg ggt tct     1288
 Gly Glu Leu Thr Leu Val Glu Tyr Gly Asn Asn Asp Thr Leu Gly Ser
         350                 355                 360

 gta cgc act gaa ttc atg aac ccc cac ctc atc agt gtt cgt att aat     1336
 Val Arg Thr Glu Phe Met Asn Pro His Leu Ile Ser Val Arg Ile Asn
     365                 370                 375

 gag agg tgt cag cga gga aca gaa gat aat aag aaa ttg gct tat ctt     1384
 Glu Arg Cys Gln Arg Gly Thr Glu Asp Asn Lys Lys Leu Ala Tyr Leu
 380                 385                 390                 395

 att gat att aag act att gct ata gtg gat ctg att ggt ggc tac aac     1432
 Ile Asp Ile Lys Thr Ile Ala Ile Val Asp Leu Ile Gly Gly Tyr Asn
                 400                 405                 410

 att ggc acc gtc agc cat gag agc cgt gtg gat tgg ctg gaa ctt aat     1480
 Ile Gly Thr Val Ser His Glu Ser Arg Val Asp Trp Leu Glu Leu Asn
             415                 420                 425

 gag act gga cac aag ctc ctc ttc agg gac cgg aaa ctt cgt ttg cat     1528
 Glu Thr Gly His Lys Leu Leu Phe Arg Asp Arg Lys Leu Arg Leu His
         430                 435                 440

 ctg tat gat att gaa agc tgc tct aag aca atg atc ctc aac ttc tgc     1576
 Leu Tyr Asp Ile Glu Ser Cys Ser Lys Thr Met Ile Leu Asn Phe Cys
     445                 450                 455

 tcc tat atg cag tgg gtc cca gga agt gac gtg ctg gta gct cag aac     1624
 Ser Tyr Met Gln Trp Val Pro Gly Ser Asp Val Leu Val Ala Gln Asn
 460                 465                 470                 475

 cga aac agt ctg tgt gta tgg tac aac att gag gca cct gag aga gtc     1672
 Arg Asn Ser Leu Cys Val Trp Tyr Asn Ile Glu Ala Pro Glu Arg Val
                 480                 485                 490

 acc atg ttc act att agg ggt gat gtt ata ggt ctg gag cgg ggc ggg     1720
 Thr Met Phe Thr Ile Arg Gly Asp Val Ile Gly Leu Glu Arg Gly Gly
             495                 500                 505

 gga aag acc gag gtg atg gtg atg gaa ggt gtg act act gtt gcc tac     1768
 Gly Lys Thr Glu Val Met Val Met Glu Gly Val Thr Thr Val Ala Tyr
         510                 515                 520

 aca ttg gat gag ggc ctc atc gag ttt gga aca gcc att gat gat ggc     1816
 Thr Leu Asp Glu Gly Leu Ile Glu Phe Gly Thr Ala Ile Asp Asp Gly
     525                 530                 535

 aac tac atc cgg gca aca gcc ttc tta gag act ctg gaa atg acc cca     1864
 Asn Tyr Ile Arg Ala Thr Ala Phe Leu Glu Thr Leu Glu Met Thr Pro
 540                 545                 550                 555

 gaa aca gag gca atg tgg aaa acc ttg agt aaa ctg gca cta gag gca     1912
 Glu Thr Glu Ala Met Trp Lys Thr Leu Ser Lys Leu Ala Leu Glu Ala
                 560                 565                 570

 agg caa cta cac att gcg gag agg tgc ttt tct gct ttg ggc caa gta     1960
 Arg Gln Leu His Ile Ala Glu Arg Cys Phe Ser Ala Leu Gly Gln Val
             575                 580                 585

 gca aaa gct cga ttc ctg cat gag acc aat gag att gca gat caa gta     2008
 Ala Lys Ala Arg Phe Leu His Glu Thr Asn Glu Ile Ala Asp Gln Val
         590                 595                 600

 tcc cgg gaa tat ggc gga gaa gga aca gac ttt tat cag gtc cga gca     2056
 Ser Arg Glu Tyr Gly Gly Glu Gly Thr Asp Phe Tyr Gln Val Arg Ala
     605                 610                 615

 cgt cta gcc atg ctg gaa aag aac tac aaa ctg gct gaa atg atc ttt     2104
 Arg Leu Ala Met Leu Glu Lys Asn Tyr Lys Leu Ala Glu Met Ile Phe
 620                 625                 630                 635

 ttg gaa cag aat gct gtg gag gag gcc atg ggc atg tac cag gag cta     2152
 Leu Glu Gln Asn Ala Val Glu Glu Ala Met Gly Met Tyr Gln Glu Leu
                 640                 645                 650

 cac cgt tgg gat gag tgt atc gct gtg gct gaa gcc aag ggg cac cca     2200
 His Arg Trp Asp Glu Cys Ile Ala Val Ala Glu Ala Lys Gly His Pro
             655                 660                 665

 gcc ctg gag aag cta cgt cgt agt tac tac cag tgg ctg atg gac aca     2248
 Ala Leu Glu Lys Leu Arg Arg Ser Tyr Tyr Gln Trp Leu Met Asp Thr
         670                 675                 680

 cag caa gag gag cga gca ggt gaa cta cag gag agc caa ggg gat ggg     2296
 Gln Gln Glu Glu Arg Ala Gly Glu Leu Gln Glu Ser Gln Gly Asp Gly
     685                 690                 695

 cta gca gcc atc agc ctc tac ctc aaa gct ggg ctc cct gcc aaa gct     2344
 Leu Ala Ala Ile Ser Leu Tyr Leu Lys Ala Gly Leu Pro Ala Lys Ala
 700                 705                 710                 715

 gct cgg ctg gtg ctg acc cga gag gaa ctg cta gcc aac aca gag ctg     2392
 Ala Arg Leu Val Leu Thr Arg Glu Glu Leu Leu Ala Asn Thr Glu Leu
                 720                 725                 730

 gta gaa cac atc act gca gcc ctt atc aag ggg gaa ctc tac gaa agg     2440
 Val Glu His Ile Thr Ala Ala Leu Ile Lys Gly Glu Leu Tyr Glu Arg
             735                 740                 745

 gca ggt gat ctc ttt gag aag att cac aat cca cag aag gcc ctg gag     2488
 Ala Gly Asp Leu Phe Glu Lys Ile His Asn Pro Gln Lys Ala Leu Glu
         750                 755                 760

 tgc tac cgt aaa ggc aac gca ttc atg aaa gcg gta gag ctg gct cga     2536
 Cys Tyr Arg Lys Gly Asn Ala Phe Met Lys Ala Val Glu Leu Ala Arg
     765                 770                 775

 ttg gcc ttc cca gtg gag gtg gtg aaa cta gag gag gca tgg ggg gac     2584
 Leu Ala Phe Pro Val Glu Val Val Lys Leu Glu Glu Ala Trp Gly Asp
 780                 785                 790                 795

 cac ctg gtg cag cag aag cag ctt gat gca gcc att aat cac tac atc     2632
 His Leu Val Gln Gln Lys Gln Leu Asp Ala Ala Ile Asn His Tyr Ile
                 800                 805                 810

 gaa gcc agg tgc tcc att aag gca att gag gcc gcc ctg ggt gcc cgc     2680
 Glu Ala Arg Cys Ser Ile Lys Ala Ile Glu Ala Ala Leu Gly Ala Arg
             815                 820                 825

 cag tgg aag aag gca att tat ata tta gat cta cag gac cgg aac act     2728
 Gln Trp Lys Lys Ala Ile Tyr Ile Leu Asp Leu Gln Asp Arg Asn Thr
         830                 835                 840

 gca tcc aaa tac tat cct ctc gtg gcc caa cac tat gca tcc ctg cag     2776
 Ala Ser Lys Tyr Tyr Pro Leu Val Ala Gln His Tyr Ala Ser Leu Gln
     845                 850                 855

 gag tat gag att gct gag gag ctc tat act aag gga gat cgg aca aaa     2824
 Glu Tyr Glu Ile Ala Glu Glu Leu Tyr Thr Lys Gly Asp Arg Thr Lys
 860                 865                 870                 875

 gat gcc ata gac atg tac acc cag gct ggt cgt tgg gaa caa gcc cac     2872
 Asp Ala Ile Asp Met Tyr Thr Gln Ala Gly Arg Trp Glu Gln Ala His
                 880                 885                 890

 aag ctg gcg atg aaa tgc atg aga cca gaa gat gtg tca gtg cta tac     2920
 Lys Leu Ala Met Lys Cys Met Arg Pro Glu Asp Val Ser Val Leu Tyr
             895                 900                 905

 atc act cag gcc cag gaa atg gag aag cag ggc aag tac cgt gag gct     2968
 Ile Thr Gln Ala Gln Glu Met Glu Lys Gln Gly Lys Tyr Arg Glu Ala
         910                 915                 920

 gaa agg cta tat gtg aca gta caa gag cct gat ctt gcc atc acc atg     3016
 Glu Arg Leu Tyr Val Thr Val Gln Glu Pro Asp Leu Ala Ile Thr Met
     925                 930                 935

 tac aaa aag cac aag ttg tat gat gac atg atc cgc ctg gta ggg aag     3064
 Tyr Lys Lys His Lys Leu Tyr Asp Asp Met Ile Arg Leu Val Gly Lys
 940                 945                 950                 955

 cac cat cca gat ctc ctc agt gat aca cac cta cat ctg ggc aag gag     3112
 His His Pro Asp Leu Leu Ser Asp Thr His Leu His Leu Gly Lys Glu
                 960                 965                 970

 ctg gag gct gaa ggc cga cta cag gag gct gag tac cac tac ctc gag     3160
 Leu Glu Ala Glu Gly Arg Leu Gln Glu Ala Glu Tyr His Tyr Leu Glu
             975                 980                 985

 gcc cag gaa tgg aag gca aca gtg aac atg tac cgg gcc agt ggg ctt     3208
 Ala Gln Glu Trp Lys Ala Thr Val Asn Met Tyr Arg Ala Ser Gly Leu
         990                 995                1000

 tgg gaa gag gcc tac agg gtg gcc aga act caa gga ggg gct aat gcc     3256
 Trp Glu Glu Ala Tyr Arg Val Ala Arg Thr Gln Gly Gly Ala Asn Ala
    1005                1010                1015

 cac aaa cac gtg gcc tat ctg tgg gca aag agc ctg gga gga gag gct     3304
 His Lys His Val Ala Tyr Leu Trp Ala Lys Ser Leu Gly Gly Glu Ala
1020                1025                1030                1035

 gca gtt aga ctg ctt aat aag ctg gga ctc ctg gaa gct gct gtt gac     3352
 Ala Val Arg Leu Leu Asn Lys Leu Gly Leu Leu Glu Ala Ala Val Asp
                1040                1045                1050

 cac gct gca gac aat tgc tcc ttt gaa ttt gcg ttt gaa ctc tct cgg     3400
 His Ala Ala Asp Asn Cys Ser Phe Glu Phe Ala Phe Glu Leu Ser Arg
            1055                1060                1065

 ctg gcc ctc aag cac aaa acc ccc gag gtt cat ctc aaa tat gct atg     3448
 Leu Ala Leu Lys His Lys Thr Pro Glu Val His Leu Lys Tyr Ala Met
        1070                1075                1080

 ttc ctg gag gat gag ggt aaa ttc gaa gag gct gaa gct gaa ttc atc     3496
 Phe Leu Glu Asp Glu Gly Lys Phe Glu Glu Ala Glu Ala Glu Phe Ile
    1085                1090                1095

 aga gct ggt aaa ccc aag gag gca gtc ctc atg ttt gtc cat aac cag     3544
 Arg Ala Gly Lys Pro Lys Glu Ala Val Leu Met Phe Val His Asn Gln
1100                1105                1110                1115

 gat tgg gag gca gct cag cgt gtg gct gag gct cac gac cct gac agt     3592
 Asp Trp Glu Ala Ala Gln Arg Val Ala Glu Ala His Asp Pro Asp Ser
                1120                1125                1130

 gtc gcc gag gtg ctt gtg gga cag gcc cgg ggg gcc ttg gag gag aag     3640
 Val Ala Glu Val Leu Val Gly Gln Ala Arg Gly Ala Leu Glu Glu Lys
            1135                1140                1145

 gac ttt cag aaa gca gaa ggg ctg ctg ctc cgg gcc cag aga cca ggc     3688
 Asp Phe Gln Lys Ala Glu Gly Leu Leu Leu Arg Ala Gln Arg Pro Gly
        1150                1155                1160

 ctg gcc ctc aat tat tat aag gag gct gga tta tgg agt gac gct ctg     3736
 Leu Ala Leu Asn Tyr Tyr Lys Glu Ala Gly Leu Trp Ser Asp Ala Leu
    1165                1170                1175

 cgc atc tgc aag gac tat gtg ccc agc cag ctg gag gct ctg cag gaa     3784
 Arg Ile Cys Lys Asp Tyr Val Pro Ser Gln Leu Glu Ala Leu Gln Glu
1180                1185                1190                1195

 gaa tat gag cgg gaa gct act aag aag ggg gcc agg ggt gtg gag gga     3832
 Glu Tyr Glu Arg Glu Ala Thr Lys Lys Gly Ala Arg Gly Val Glu Gly
                1200                1205                1210

 ttt gtg gaa caa gct cga cac tgg gag cag gct gga gag tac agc cgt     3880
 Phe Val Glu Gln Ala Arg His Trp Glu Gln Ala Gly Glu Tyr Ser Arg
            1215                1220                1225

 gcc gtg gac tgc tac ctc aaa gtg cga gac tct gga aac agc ggc ctg     3928
 Ala Val Asp Cys Tyr Leu Lys Val Arg Asp Ser Gly Asn Ser Gly Leu
        1230                1235                1240

 gcg gag aag tgc tgg atg aag gca gct gaa ctc tcc atc aag ttt ctg     3976
 Ala Glu Lys Cys Trp Met Lys Ala Ala Glu Leu Ser Ile Lys Phe Leu
    1245                1250                1255

 cct ccc caa cgt aat atg gaa gtc gtt ctg gct gta gga ccc cag ctg     4024
 Pro Pro Gln Arg Asn Met Glu Val Val Leu Ala Val Gly Pro Gln Leu
1260                1265                1270                1275

 att gga att gga aag cac agt gca gct gca gag ctc tat ctg aat ctg     4072
 Ile Gly Ile Gly Lys His Ser Ala Ala Ala Glu Leu Tyr Leu Asn Leu
                1280                1285                1290

 gac ctt gtc aag gaa gca atc gat gct ttc atc gag ggt gag gag tgg     4120
 Asp Leu Val Lys Glu Ala Ile Asp Ala Phe Ile Glu Gly Glu Glu Trp
            1295                1300                1305

 aac aag gcg aag cgt gta gct aag gag tta gat ccc agg tat gaa gac     4168
 Asn Lys Ala Lys Arg Val Ala Lys Glu Leu Asp Pro Arg Tyr Glu Asp
        1310                1315                1320

 tat gtg gac cag cat tat aaa gag ttc ctc aag aat cag ggc aaa gtg     4216
 Tyr Val Asp Gln His Tyr Lys Glu Phe Leu Lys Asn Gln Gly Lys Val
    1325                1330                1335

 gac tcg ctg gtg ggt gtg gat gtg ata gct gct ttg gac ctg tat gtg     4264
 Asp Ser Leu Val Gly Val Asp Val Ile Ala Ala Leu Asp Leu Tyr Val
1340                1345                1350                1355

 gag cag ggc cag tgg gac aag tgc att gaa aca gct acc aag cag aac     4312
 Glu Gln Gly Gln Trp Asp Lys Cys Ile Glu Thr Ala Thr Lys Gln Asn
                1360                1365                1370

 tac aag att ctg cac aag tat gtg gct ttg tat gca act cac ttg atc     4360
 Tyr Lys Ile Leu His Lys Tyr Val Ala Leu Tyr Ala Thr His Leu Ile
            1375                1380                1385

 cgg gag ggt agc tct gcc cag gca ttg gcc ctg tat gta cag cac gga     4408
 Arg Glu Gly Ser Ser Ala Gln Ala Leu Ala Leu Tyr Val Gln His Gly
        1390                1395                1400

 gcc cct gct aac cca cag aac ttc aat atc tac aaa agg atc ttc act     4456
 Ala Pro Ala Asn Pro Gln Asn Phe Asn Ile Tyr Lys Arg Ile Phe Thr
    1405                1410                1415

 gac atg gtg agc tct cct gga acc aac tgt gcc gag gcc tat cat agc     4504
 Asp Met Val Ser Ser Pro Gly Thr Asn Cys Ala Glu Ala Tyr His Ser
1420                1425                1430                1435

 tgg gct gat ctt cga gat gtc ctc ttc aac ctg ttt gaa aac ctg gtg     4552
 Trp Ala Asp Leu Arg Asp Val Leu Phe Asn Leu Phe Glu Asn Leu Val
                1440                1445                1450

 aag tcc agt gag gca aac tct cca gcc cat gag gag ttc aag acg atg     4600
 Lys Ser Ser Glu Ala Asn Ser Pro Ala His Glu Glu Phe Lys Thr Met
            1455                1460                1465

 ctg ctg atc gct cat tac tat gcc acg cgc tct gca gcc cag agt gtc     4648
 Leu Leu Ile Ala His Tyr Tyr Ala Thr Arg Ser Ala Ala Gln Ser Val
        1470                1475                1480

 aaa cag ctg gaa acc gtg gct gcc agg ctt tct gtt tca ctc ttg cgt     4696
 Lys Gln Leu Glu Thr Val Ala Ala Arg Leu Ser Val Ser Leu Leu Arg
    1485                1490                1495

 cac acc cag cta cta cct gta gac aaa gcc ttc tat gaa gca ggc att     4744
 His Thr Gln Leu Leu Pro Val Asp Lys Ala Phe Tyr Glu Ala Gly Ile
1500                1505                1510                1515

 gct gcc aag gca gtt ggc tgg gat aac atg gca ttc atc ttc ctc aat     4792
 Ala Ala Lys Ala Val Gly Trp Asp Asn Met Ala Phe Ile Phe Leu Asn
                1520                1525                1530

 cgc ttt ttg gac ctg acc gat gca atc gag gaa ggg act cta gat ggc     4840
 Arg Phe Leu Asp Leu Thr Asp Ala Ile Glu Glu Gly Thr Leu Asp Gly
            1535                1540                1545

 ctt gac cac tct gat ttt cag gat aca gac att ccc ttt gag gtg cca     4888
 Leu Asp His Ser Asp Phe Gln Asp Thr Asp Ile Pro Phe Glu Val Pro
        1550                1555                1560

 ctc cca gct aag cag cat gta ccg gag gct gag aga gaa gag gtt cga     4936
 Leu Pro Ala Lys Gln His Val Pro Glu Ala Glu Arg Glu Glu Val Arg
    1565                1570                1575

 gac tgg gtg ctt aca gtc tcc atg gac cag cgg ctg gag cag gtt ctg     4984
 Asp Trp Val Leu Thr Val Ser Met Asp Gln Arg Leu Glu Gln Val Leu
1580                1585                1590                1595

 cct cgg gat gag cgt ggc gcc tac gag gcc tcc cta gtg gca gcg agc     5032
 Pro Arg Asp Glu Arg Gly Ala Tyr Glu Ala Ser Leu Val Ala Ala Ser
                1600                1605                1610

 act ggt gtt cga gcc ctg ccc tgc ctt att aca gga tac ccc att ctg     5080
 Thr Gly Val Arg Ala Leu Pro Cys Leu Ile Thr Gly Tyr Pro Ile Leu
            1615                1620                1625

 agg aac aaa att gaa ttt aag cgg cca ggg aag gct gct aac aag gac     5128
 Arg Asn Lys Ile Glu Phe Lys Arg Pro Gly Lys Ala Ala Asn Lys Asp
        1630                1635                1640

 aac tgg aat aaa ttc ctt atg gcc atc aag acc tcc cac agc cca gtg     5176
 Asn Trp Asn Lys Phe Leu Met Ala Ile Lys Thr Ser His Ser Pro Val
    1645                1650                1655

 tgc cag gac gtg ctg aaa ttc atc agt cag tgg tgt gga ggg ctc ccc     5224
 Cys Gln Asp Val Leu Lys Phe Ile Ser Gln Trp Cys Gly Gly Leu Pro
1660                1665                1670                1675

 agc acc agc ttt tcc ttt cag tag ttggtagagc tgaggaagag ttagggcctc    5278
 Ser Thr Ser Phe Ser Phe Gln 
                1680

 tccctcatta aagttttata aataaaaaaa aaaaa                              5313




      <210> 291
      <211> 1897
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(1414)

      <400> 291
 aaatgca  atg gca cat cgt gat tct gag atg aaa gaa gaa tgt cta agg      49
          Met Ala His Arg Asp Ser Glu Met Lys Glu Glu Cys Leu Arg
            1               5                  10

 gaa gac ctg aag ttt tac ttc atg agc cct tgt gaa aaa tac cga gcc       97
 Glu Asp Leu Lys Phe Tyr Phe Met Ser Pro Cys Glu Lys Tyr Arg Ala
  15                  20                  25                  30

 aga cgc cag att ccg tgg aaa ctg ggt ttg cag att ttg aag ata gtc      145
 Arg Arg Gln Ile Pro Trp Lys Leu Gly Leu Gln Ile Leu Lys Ile Val
                  35                  40                  45

 atg gtc acc aca cag tat cat cag cta aag gac att acc ctg ggg acc      193
 Met Val Thr Thr Gln Tyr His Gln Leu Lys Asp Ile Thr Leu Gly Thr
              50                  55                  60

 ctt ggt tat gga gaa aat gaa gac aat aga att ggc tta aaa gtc tgt      241
 Leu Gly Tyr Gly Glu Asn Glu Asp Asn Arg Ile Gly Leu Lys Val Cys
          65                  70                  75

 aag cag cat tac aag aaa ggg acc atg ttt cct tct aat gag aca ctg      289
 Lys Gln His Tyr Lys Lys Gly Thr Met Phe Pro Ser Asn Glu Thr Leu
      80                  85                  90

 aat att gac aac gac gtt gag ctc gat tgt gtt caa tta gac ctt cag      337
 Asn Ile Asp Asn Asp Val Glu Leu Asp Cys Val Gln Leu Asp Leu Gln
  95                 100                 105                 110

 gac ctc tcc aag aag cct ccg gac tgg aag aac tca tca ttc ttc aga      385
 Asp Leu Ser Lys Lys Pro Pro Asp Trp Lys Asn Ser Ser Phe Phe Arg
                 115                 120                 125

 ctg gaa ttt tat cga tac gca gag atc agg ggc ata ttt tct aag tcc      433
 Leu Glu Phe Tyr Arg Tyr Ala Glu Ile Arg Gly Ile Phe Ser Lys Ser
             130                 135                 140

 aag tat agg ttg cca att ttc tgt gaa aag aaa cta acc ttt gtc aaa      481
 Lys Tyr Arg Leu Pro Ile Phe Cys Glu Lys Lys Leu Thr Phe Val Lys
         145                 150                 155

 tat gtg att tgg aat atc att ata aag atc aaa atg atg gaa att tcc      529
 Tyr Val Ile Trp Asn Ile Ile Ile Lys Ile Lys Met Met Glu Ile Ser
     160                 165                 170

 aag cta gtc agt caa atg cat ttc cag aac act cag aaa aat gct cag      577
 Lys Leu Val Ser Gln Met His Phe Gln Asn Thr Gln Lys Asn Ala Gln
 175                 180                 185                 190

 tat gtc ctg gtg ttt gat gca ttt gtc att gtg att tgc ttg gca tct      625
 Tyr Val Leu Val Phe Asp Ala Phe Val Ile Val Ile Cys Leu Ala Ser
                 195                 200                 205

 ctt att ctg tgt aca aga tcc att gtt ctt gct cta agg tta cgg aag      673
 Leu Ile Leu Cys Thr Arg Ser Ile Val Leu Ala Leu Arg Leu Arg Lys
             210                 215                 220

 aga ttt cta aat ttc ttc ctg gag aag tac aag cgg cct gtg tgt gac      721
 Arg Phe Leu Asn Phe Phe Leu Glu Lys Tyr Lys Arg Pro Val Cys Asp
         225                 230                 235

 acc gac cag tgg gag ttc atc aac ggc tgg tat gtc ctg gtg att atc      769
 Thr Asp Gln Trp Glu Phe Ile Asn Gly Trp Tyr Val Leu Val Ile Ile
     240                 245                 250

 agc gac cta atg aca atc att ggc tcc ata tta aaa atg gaa atc aaa      817
 Ser Asp Leu Met Thr Ile Ile Gly Ser Ile Leu Lys Met Glu Ile Lys
 255                 260                 265                 270

 gca aag aat ctc aca aac tat gat ctc tgc agc att ttt ctt gga acc      865
 Ala Lys Asn Leu Thr Asn Tyr Asp Leu Cys Ser Ile Phe Leu Gly Thr
                 275                 280                 285

 tct acg ctc ttg gtt tgg gtt gga gtc atc aga tac ctg ggt tat ttc      913
 Ser Thr Leu Leu Val Trp Val Gly Val Ile Arg Tyr Leu Gly Tyr Phe
             290                 295                 300

 cag gca tat aat gtg ctg att tta aca atg cag gcc tca ctg cca aaa      961
 Gln Ala Tyr Asn Val Leu Ile Leu Thr Met Gln Ala Ser Leu Pro Lys
         305                 310                 315

 gtt ctt cgg ttt tgt gct tgt gct ggt atg att tat ctg ggt tac aca     1009
 Val Leu Arg Phe Cys Ala Cys Ala Gly Met Ile Tyr Leu Gly Tyr Thr
     320                 325                 330

 ttc tgt ggc tgg att gtc tta gga cca tac cat gac aag ttt gaa aat     1057
 Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp Lys Phe Glu Asn
 335                 340                 345                 350

 ctg aac aca gtt gct gag tgt ctg ttt tct ctg gtc aac ggt gat gac     1105
 Leu Asn Thr Val Ala Glu Cys Leu Phe Ser Leu Val Asn Gly Asp Asp
                 355                 360                 365

 atg ttt gca acc ttt gcc caa atc cag cag aag agc atc ttg gtg tgg     1153
 Met Phe Ala Thr Phe Ala Gln Ile Gln Gln Lys Ser Ile Leu Val Trp
             370                 375                 380

 ctg ttc agt cgt ctg tat tta tat tcc ttc atc agc ctt ttt ata tat     1201
 Leu Phe Ser Arg Leu Tyr Leu Tyr Ser Phe Ile Ser Leu Phe Ile Tyr
         385                 390                 395

 atg att ctc agt ctt ttt att gca ctt att aca gat tct tat gac acc     1249
 Met Ile Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp Ser Tyr Asp Thr
     400                 405                 410

 att aag aaa ttc caa cag aat ggg ttt cct gaa acg gat ttg cag gaa     1297
 Ile Lys Lys Phe Gln Gln Asn Gly Phe Pro Glu Thr Asp Leu Gln Glu
 415                 420                 425                 430

 ttc ctg aag gaa tgc agt agc aaa gaa gag tat cag aaa gag tcc tca     1345
 Phe Leu Lys Glu Cys Ser Ser Lys Glu Glu Tyr Gln Lys Glu Ser Ser
                 435                 440                 445

 gcc ttc ctg tcc tgc atc tgc tgt cgg agg agg aaa aga agt gat gat     1393
 Ala Phe Leu Ser Cys Ile Cys Cys Arg Arg Arg Lys Arg Ser Asp Asp
             450                 455                 460

 cac ttg ata cct att agc taa ag ttctgctaaa gatgattaaa gttcaggcat     1446
 His Leu Ile Pro Ile Ser 
         465

 ccttatccag cagctgagca gaggaacccc aaatgacttg gacaagcagt tccaaaatga   1506

 ctctcttatt taatgtggag tgggaaagag gactcacagt tagccagctg accatgactg   1566

 aagttccagc tttacttgtt ataaaacttg aatgataaag aatagaccat gggctactac   1626

 tgggcattag tgcaatataa ccagccgata ataaaatttc tctattagtc tgttacttta   1686

 tgacatgatc tcggaatggc aaagattcat ttccagaagt gtgcgaaata atagttctta   1746

 ccctgttaat tacacattgt gcgtcctcgg ccccaaggga ctggcacaaa gggaactgcg   1806

 gtggaaaaca tttgttaata ccgggctcgg tcacaaaaga cccggtgggg catccattta   1866

 agagtcacgg gcgaactaca cgggcaagac c                                  1897




      <210> 292
      <211> 1640
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1629)

      <400> 292
  atg gca cat cgt gat tct gag atg aaa gaa gaa tgt cta agg gaa gac      48
  Met Ala His Arg Asp Ser Glu Met Lys Glu Glu Cys Leu Arg Glu Asp
    1               5                  10                  15

 ctg aag ttt tac ttc atg agc cct tgt gaa aaa tac cga gcc aga cgc       96
 Leu Lys Phe Tyr Phe Met Ser Pro Cys Glu Lys Tyr Arg Ala Arg Arg
              20                  25                  30

 cag att ccg tgg aaa ctg ggt ttg cag att ttg aag ata gtc atg gtc      144
 Gln Ile Pro Trp Lys Leu Gly Leu Gln Ile Leu Lys Ile Val Met Val
          35                  40                  45

 acc aca cag ctt gtt cgt ttt ggt tta agt aac cag ctg gtg gtt gct      192
 Thr Thr Gln Leu Val Arg Phe Gly Leu Ser Asn Gln Leu Val Val Ala
      50                  55                  60

 ttc aaa gaa gat aac act gtt gct ttt aag cac ttg ttt ttg aaa gga      240
 Phe Lys Glu Asp Asn Thr Val Ala Phe Lys His Leu Phe Leu Lys Gly
  65                  70                  75                  80

 tat tct ggt aca gat gaa gat gac tac agc tgc agt gta tat act caa      288
 Tyr Ser Gly Thr Asp Glu Asp Asp Tyr Ser Cys Ser Val Tyr Thr Gln
                  85                  90                  95

 gag gat gcc tat gag agc atc ttt ttt gct att aat cag tat cat cag      336
 Glu Asp Ala Tyr Glu Ser Ile Phe Phe Ala Ile Asn Gln Tyr His Gln
             100                 105                 110

 cta aag gac att acc ctg ggg acc ctt ggt tat gga gaa aat gaa gac      384
 Leu Lys Asp Ile Thr Leu Gly Thr Leu Gly Tyr Gly Glu Asn Glu Asp
         115                 120                 125

 aat aga att ggc tta aaa gtc tgt aag cag cat tac aag aaa ggg acc      432
 Asn Arg Ile Gly Leu Lys Val Cys Lys Gln His Tyr Lys Lys Gly Thr
     130                 135                 140

 atg ttt cct tct aat gag aca ctg aat att gac aac gac gtt gag ctc      480
 Met Phe Pro Ser Asn Glu Thr Leu Asn Ile Asp Asn Asp Val Glu Leu
 145                 150                 155                 160

 gat tgt gtt caa tta gac ctt cag gac ctc tcc aag aag cct ccg gac      528
 Asp Cys Val Gln Leu Asp Leu Gln Asp Leu Ser Lys Lys Pro Pro Asp
                 165                 170                 175

 tgg aag aac tca tca ttc ttc aga ctg gaa ttt tat cgg ctc tta cag      576
 Trp Lys Asn Ser Ser Phe Phe Arg Leu Glu Phe Tyr Arg Leu Leu Gln
             180                 185                 190

 gtt gaa atc tcc ttt cat ctt aaa ggc att gac cta cag aca att cat      624
 Val Glu Ile Ser Phe His Leu Lys Gly Ile Asp Leu Gln Thr Ile His
         195                 200                 205

 tcc cgt gag tta cca gac tgt tat gtc ttt cag aat acg gca agt atc      672
 Ser Arg Glu Leu Pro Asp Cys Tyr Val Phe Gln Asn Thr Ala Ser Ile
     210                 215                 220

 ttt att atc ttt gac aat aaa gct cac agt ggc aaa atc aaa atc tat      720
 Phe Ile Ile Phe Asp Asn Lys Ala His Ser Gly Lys Ile Lys Ile Tyr
 225                 230                 235                 240

 ttt gac agt gat gcc aaa att gaa gaa tgt aaa gac ttg aac ata ttt      768
 Phe Asp Ser Asp Ala Lys Ile Glu Glu Cys Lys Asp Leu Asn Ile Phe
                 245                 250                 255

 gga tct act cag aaa aat gct cag tat gtc ctg gtg ttt gat gca ttt      816
 Gly Ser Thr Gln Lys Asn Ala Gln Tyr Val Leu Val Phe Asp Ala Phe
             260                 265                 270

 gtc att gtg att tgc ttg gca tct ctt att ctg tgt aca aga tcc att      864
 Val Ile Val Ile Cys Leu Ala Ser Leu Ile Leu Cys Thr Arg Ser Ile
         275                 280                 285

 gtt ctt gct cta agg tta cgg aag aga ttt cta aat ttc ttc ctg gag      912
 Val Leu Ala Leu Arg Leu Arg Lys Arg Phe Leu Asn Phe Phe Leu Glu
     290                 295                 300

 aag tac aag cgg cct gtg tgt gac acc gac cag tgg gag ttc atc aac      960
 Lys Tyr Lys Arg Pro Val Cys Asp Thr Asp Gln Trp Glu Phe Ile Asn
 305                 310                 315                 320

 ggc tgg tat gtc ctg gtg att atc agc gac cta atg aca atc att ggc     1008
 Gly Trp Tyr Val Leu Val Ile Ile Ser Asp Leu Met Thr Ile Ile Gly
                 325                 330                 335

 tcc ata tta aaa atg gaa atc aaa gca aag aat ctc aca aac tat gat     1056
 Ser Ile Leu Lys Met Glu Ile Lys Ala Lys Asn Leu Thr Asn Tyr Asp
             340                 345                 350

 ctc tgc agc att ttt ctt gga acc tct acg ctc ttg gtt tgg gtt gga     1104
 Leu Cys Ser Ile Phe Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly
         355                 360                 365

 gtc atc aga tac ctg ggt tat ttc cag gca tat aat gtg ctg att tta     1152
 Val Ile Arg Tyr Leu Gly Tyr Phe Gln Ala Tyr Asn Val Leu Ile Leu
     370                 375                 380

 aca atg cag gcc tca ctg cca aaa gtt ctt cgg ttt tgt gct tgt gct     1200
 Thr Met Gln Ala Ser Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala
 385                 390                 395                 400

 ggt atg att tat ctg ggt tac aca ttc tgt ggc tgg att gtc tta gga     1248
 Gly Met Ile Tyr Leu Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly
                 405                 410                 415

 cca tac cat gac aag ttt gaa aat ctg aac aca gtt gct gag tgt ctg     1296
 Pro Tyr His Asp Lys Phe Glu Asn Leu Asn Thr Val Ala Glu Cys Leu
             420                 425                 430

 ttt tct ctg gtc aac ggt gat gac atg ttt gca acc ttt gcc caa atc     1344
 Phe Ser Leu Val Asn Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile
         435                 440                 445

 cag cag aag agc atc ttg gtg tgg ctg ttc agt cgt ctg tat tta tat     1392
 Gln Gln Lys Ser Ile Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr
     450                 455                 460

 tcc ttc atc agc ctt ttt ata tat atg att ctc agt ctt ttt att gca     1440
 Ser Phe Ile Ser Leu Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala
 465                 470                 475                 480

 ctt att aca gat tct tat gac acc att aag aaa ttc caa cag aat ggg     1488
 Leu Ile Thr Asp Ser Tyr Asp Thr Ile Lys Lys Phe Gln Gln Asn Gly
                 485                 490                 495

 ttt cct gaa acg gat ttg cag gaa ttc ctg aag gaa tgc agt agc aaa     1536
 Phe Pro Glu Thr Asp Leu Gln Glu Phe Leu Lys Glu Cys Ser Ser Lys
             500                 505                 510

 gaa gag tat cag aaa gag tcc tca gcc ttc ctg tcc tgc atc tgc tgt     1584
 Glu Glu Tyr Gln Lys Glu Ser Ser Ala Phe Leu Ser Cys Ile Cys Cys
         515                 520                 525

 cgg agg agg aaa aga agt gat gat cac ttg ata cct att agc taa agt     1632
 Arg Arg Arg Lys Arg Ser Asp Asp His Leu Ile Pro Ile Ser 
     530                 535                 540

 tctgctaa                                                            1640




      <210> 293
      <211> 8405
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (227)..(7927)

      <400> 293
 tgcagcgagt ctgaggagcc gaggaaggca gggaagatgg cgatcctcca ttgctgagac     60

 ccggcagaag cacatgagac tcccaaacaa cttccacaac aataacccga gcaggaagag    120

 gagaaagaga aagaggataa ggaggcggtg gggctggaga acccgaagca cctcccggcg    180

 ccgggacgct tcttctgttc ctaatgtgag aggctagacc cagatc   atg gag gtg     235
                                                      Met Glu Val
                                                        1

 ctt cag tgt gat ggc tgt gat ttc cga gcc ccg tct tat gaa gat ctc      283
 Leu Gln Cys Asp Gly Cys Asp Phe Arg Ala Pro Ser Tyr Glu Asp Leu
       5                  10                  15

 aag gca cac att cag gat gtc cac acg gca ttt ctg cag cca act gat      331
 Lys Ala His Ile Gln Asp Val His Thr Ala Phe Leu Gln Pro Thr Asp
  20                  25                  30                  35

 gtt gct gag gac aat gtg aat gag cta cga tgt ggg tcc gtg aat gcc      379
 Val Ala Glu Asp Asn Val Asn Glu Leu Arg Cys Gly Ser Val Asn Ala
                  40                  45                  50

 agt aat cag aca gag gtg gag ttt tct tct ata aag gat gaa ttt gcc      427
 Ser Asn Gln Thr Glu Val Glu Phe Ser Ser Ile Lys Asp Glu Phe Ala
              55                  60                  65

 att gca gaa gat tta tca ggt caa aat gca act tca ttg ggg acc gga      475
 Ile Ala Glu Asp Leu Ser Gly Gln Asn Ala Thr Ser Leu Gly Thr Gly
          70                  75                  80

 ggt tac tat ggc cac agt cca gga tat tat ggt cag cat att gcc gct      523
 Gly Tyr Tyr Gly His Ser Pro Gly Tyr Tyr Gly Gln His Ile Ala Ala
      85                  90                  95

 aat ccc aaa cca aca aac aag ttt ttt caa tgc aag ttc tgt gta cgc      571
 Asn Pro Lys Pro Thr Asn Lys Phe Phe Gln Cys Lys Phe Cys Val Arg
 100                 105                 110                 115

 tac ttc agg tca aaa aac ctc ctc ata gaa cac act aga aag gtc cat      619
 Tyr Phe Arg Ser Lys Asn Leu Leu Ile Glu His Thr Arg Lys Val His
                 120                 125                 130

 gga gct caa gct gaa ggg agt tca tca gga ccc cct gtc ccg gga tcc      667
 Gly Ala Gln Ala Glu Gly Ser Ser Ser Gly Pro Pro Val Pro Gly Ser
             135                 140                 145

 tta aat tat aat atc atg atg cac gag gga ttt gga aag gtc ttc tct      715
 Leu Asn Tyr Asn Ile Met Met His Glu Gly Phe Gly Lys Val Phe Ser
         150                 155                 160

 tgc cag ttt tgc aca tac aag tca cca aga agg gca aga ata att aag      763
 Cys Gln Phe Cys Thr Tyr Lys Ser Pro Arg Arg Ala Arg Ile Ile Lys
     165                 170                 175

 cat cag aag atg tat cac aaa aac aat ttg aag gag acc act gct ccc      811
 His Gln Lys Met Tyr His Lys Asn Asn Leu Lys Glu Thr Thr Ala Pro
 180                 185                 190                 195

 cca cct gct cct gct cca atg cca gac cct gtg gtt ccg ccc gta tca      859
 Pro Pro Ala Pro Ala Pro Met Pro Asp Pro Val Val Pro Pro Val Ser
                 200                 205                 210

 ctg cag gac ccc tgc aag gaa ctg cca gca gag gtt gtg gag cgc agc      907
 Leu Gln Asp Pro Cys Lys Glu Leu Pro Ala Glu Val Val Glu Arg Ser
             215                 220                 225

 atc tta gag tct atg gtc aag cct ttg acc aaa tct cga ggc aac ttt      955
 Ile Leu Glu Ser Met Val Lys Pro Leu Thr Lys Ser Arg Gly Asn Phe
         230                 235                 240

 tgt tgt gag tgg tgc agc tac cag acc ccc cgc cga gaa cgc tgg tgt     1003
 Cys Cys Glu Trp Cys Ser Tyr Gln Thr Pro Arg Arg Glu Arg Trp Cys
     245                 250                 255

 gac cac atg atg aat aaa cac cgc agt atg gtc aag atc ctt tcc agt     1051
 Asp His Met Met Asn Lys His Arg Ser Met Val Lys Ile Leu Ser Ser
 260                 265                 270                 275

 ctc aga cag caa caa gaa gga act aat cta cct gat gtg ccg aac aag     1099
 Leu Arg Gln Gln Gln Glu Gly Thr Asn Leu Pro Asp Val Pro Asn Lys
                 280                 285                 290

 agt gcc ccc agc ccc act tcc aac tcc acc tat ctg acc atg aat gct     1147
 Ser Ala Pro Ser Pro Thr Ser Asn Ser Thr Tyr Leu Thr Met Asn Ala
             295                 300                 305

 gca agc cgg gag ata ccc aat act acc gtc tcc aac ttc agg ggc tcc     1195
 Ala Ser Arg Glu Ile Pro Asn Thr Thr Val Ser Asn Phe Arg Gly Ser
         310                 315                 320

 atg ggc aac tcc atc atg aga ccc aat tct tca gct tcc aag ttt tcg     1243
 Met Gly Asn Ser Ile Met Arg Pro Asn Ser Ser Ala Ser Lys Phe Ser
     325                 330                 335

 ccc atg tct tac cct cag atg aag ccg aag tca cct cac aat tct ggt     1291
 Pro Met Ser Tyr Pro Gln Met Lys Pro Lys Ser Pro His Asn Ser Gly
 340                 345                 350                 355

 cta gtt aac ttg aca gag aga tcc cgt tat gga atg act gac atg acc     1339
 Leu Val Asn Leu Thr Glu Arg Ser Arg Tyr Gly Met Thr Asp Met Thr
                 360                 365                 370

 aat tct tct gct gac ctg gaa act aac agc atg cta aat gac tct agt     1387
 Asn Ser Ser Ala Asp Leu Glu Thr Asn Ser Met Leu Asn Asp Ser Ser
             375                 380                 385

 tct gat gaa gag tta aat gaa ata gac agt gag aat ggt tta agt gct     1435
 Ser Asp Glu Glu Leu Asn Glu Ile Asp Ser Glu Asn Gly Leu Ser Ala
         390                 395                 400

 atg gat cac cag aca tca ggc ctg tct gca gag cag ctg atg ggc tca     1483
 Met Asp His Gln Thr Ser Gly Leu Ser Ala Glu Gln Leu Met Gly Ser
     405                 410                 415

 gat ggc aac aaa tta ttg gag acc aag ggg att cca ttt aga aga ttc     1531
 Asp Gly Asn Lys Leu Leu Glu Thr Lys Gly Ile Pro Phe Arg Arg Phe
 420                 425                 430                 435

 atg aat agg ttc cag tgc ccc ttt tgt cct ttc ctc acc atg cat cga     1579
 Met Asn Arg Phe Gln Cys Pro Phe Cys Pro Phe Leu Thr Met His Arg
                 440                 445                 450

 cgt agc atc tct cgt cac ata gaa aac atc cac tta tct gga aag aca     1627
 Arg Ser Ile Ser Arg His Ile Glu Asn Ile His Leu Ser Gly Lys Thr
             455                 460                 465

 gct gtc tac aaa tgt gac gaa tgt ccg ttt act tgc aag agc tcg ttg     1675
 Ala Val Tyr Lys Cys Asp Glu Cys Pro Phe Thr Cys Lys Ser Ser Leu
         470                 475                 480

 aaa ctt ggg gct cac aaa cag tgt cac acg ggt aca acg tca gat tgg     1723
 Lys Leu Gly Ala His Lys Gln Cys His Thr Gly Thr Thr Ser Asp Trp
     485                 490                 495

 gat gct gtg aat tcc cag agt gaa agc att tct tcc tca ctg aat gaa     1771
 Asp Ala Val Asn Ser Gln Ser Glu Ser Ile Ser Ser Ser Leu Asn Glu
 500                 505                 510                 515

 ggt gtg gtg tct tat gag agc tca agc atc aat ggt aga aag tca gga     1819
 Gly Val Val Ser Tyr Glu Ser Ser Ser Ile Asn Gly Arg Lys Ser Gly
                 520                 525                 530

 gtc atg ttg gat ccc ttg cag cag caa cag cca ccg cag cca cca cca     1867
 Val Met Leu Asp Pro Leu Gln Gln Gln Gln Pro Pro Gln Pro Pro Pro
             535                 540                 545

 ccg ccg ccg cca cca cca cca tca cag cca cag cca ctg cag cag cca     1915
 Pro Pro Pro Pro Pro Pro Pro Ser Gln Pro Gln Pro Leu Gln Gln Pro
         550                 555                 560

 cag cca cca cag ctg cag cca cca cat cag gtg cca ccc cag cca caa     1963
 Gln Pro Pro Gln Leu Gln Pro Pro His Gln Val Pro Pro Gln Pro Gln
     565                 570                 575

 aca cag cca cca cca acg cag cag cca cag cca ccc aca caa gcc gca     2011
 Thr Gln Pro Pro Pro Thr Gln Gln Pro Gln Pro Pro Thr Gln Ala Ala
 580                 585                 590                 595

 cct ctg cac cca tac aaa tgc acc atg tgt aat tac tcc acc aca act     2059
 Pro Leu His Pro Tyr Lys Cys Thr Met Cys Asn Tyr Ser Thr Thr Thr
                 600                 605                 610

 ctg aaa ggg cta aga gtc cat cag cag cat aaa cat tca ttc tgt gac     2107
 Leu Lys Gly Leu Arg Val His Gln Gln His Lys His Ser Phe Cys Asp
             615                 620                 625

 aac ttg cca aaa ttc gag ggg cag ccc tca agc cta cca ttg gaa aat     2155
 Asn Leu Pro Lys Phe Glu Gly Gln Pro Ser Ser Leu Pro Leu Glu Asn
         630                 635                 640

 gag aca gac agc cac ccc tct tcc agc aac act gtg aag aaa agt cag     2203
 Glu Thr Asp Ser His Pro Ser Ser Ser Asn Thr Val Lys Lys Ser Gln
     645                 650                 655

 acc tca att ctt ggg ttg tcc tcc aag aac aat ttt gta gct aaa gcc     2251
 Thr Ser Ile Leu Gly Leu Ser Ser Lys Asn Asn Phe Val Ala Lys Ala
 660                 665                 670                 675

 tct agg aag ctc gcc aat gac ttt cct cta gat ttg tca ccc gtg aag     2299
 Ser Arg Lys Leu Ala Asn Asp Phe Pro Leu Asp Leu Ser Pro Val Lys
                 680                 685                 690

 aag aga acc agg att gac gag ata gca agc aac ctt cag agc aaa att     2347
 Lys Arg Thr Arg Ile Asp Glu Ile Ala Ser Asn Leu Gln Ser Lys Ile
             695                 700                 705

 aac caa acc aaa cag cag gaa gat gca gtg atc aat gtt gag gat gat     2395
 Asn Gln Thr Lys Gln Gln Glu Asp Ala Val Ile Asn Val Glu Asp Asp
         710                 715                 720

 gaa aag gaa gag gaa gac aac gaa gtc gag ata gag gtt gag ttg gac     2443
 Glu Lys Glu Glu Glu Asp Asn Glu Val Glu Ile Glu Val Glu Leu Asp
     725                 730                 735

 agg gag gaa gaa ccg aca gaa ccc atc ata gag gtt ccc act tcc ttt     2491
 Arg Glu Glu Glu Pro Thr Glu Pro Ile Ile Glu Val Pro Thr Ser Phe
 740                 745                 750                 755

 tct gcc caa cag ata tgg gta aga gat acc agt gag ccc cag aaa gag     2539
 Ser Ala Gln Gln Ile Trp Val Arg Asp Thr Ser Glu Pro Gln Lys Glu
                 760                 765                 770

 ccc aac ttc aga aac atc acc cac gat tac aat gcc acc aat ggg gct     2587
 Pro Asn Phe Arg Asn Ile Thr His Asp Tyr Asn Ala Thr Asn Gly Ala
             775                 780                 785

 gag att gag ctc acc ctt tct gaa gat gaa gag gat tat tat ggc tcc     2635
 Glu Ile Glu Leu Thr Leu Ser Glu Asp Glu Glu Asp Tyr Tyr Gly Ser
         790                 795                 800

 tca aca aac ttg aaa gat cac caa gtt tcc aat act gct ctg ctg aat     2683
 Ser Thr Asn Leu Lys Asp His Gln Val Ser Asn Thr Ala Leu Leu Asn
     805                 810                 815

 acc caa act ccc atc tat ggg act gag cac aat agt gaa aac aca gac     2731
 Thr Gln Thr Pro Ile Tyr Gly Thr Glu His Asn Ser Glu Asn Thr Asp
 820                 825                 830                 835

 ttt ggt gac tct gga agg ctt tac tat tgt aaa cac tgt gac ttt aac     2779
 Phe Gly Asp Ser Gly Arg Leu Tyr Tyr Cys Lys His Cys Asp Phe Asn
                 840                 845                 850

 aac aaa tct gcc cgg agt gtt agc acc cac tac caa cga atg cac cca     2827
 Asn Lys Ser Ala Arg Ser Val Ser Thr His Tyr Gln Arg Met His Pro
             855                 860                 865

 tac att aaa ttc agc ttt agg tac atc ttg gac ccc aat gat cac agt     2875
 Tyr Ile Lys Phe Ser Phe Arg Tyr Ile Leu Asp Pro Asn Asp His Ser
         870                 875                 880

 gca gtg tac agg tgc ctg gaa tgc tac atc gat tac acc aac ttc gaa     2923
 Ala Val Tyr Arg Cys Leu Glu Cys Tyr Ile Asp Tyr Thr Asn Phe Glu
     885                 890                 895

 gat ctc cag cag cat tat ggc gag cac cac cca gaa gcc atg aat gta     2971
 Asp Leu Gln Gln His Tyr Gly Glu His His Pro Glu Ala Met Asn Val
 900                 905                 910                 915

 ctc aac ttt gat cac tcg gac ctg atc tac cgg tgt cgg ttt tgt tca     3019
 Leu Asn Phe Asp His Ser Asp Leu Ile Tyr Arg Cys Arg Phe Cys Ser
                 920                 925                 930

 tac acg agc ccg aat gtt aga agc ctg atg cca cat tac caa aga atg     3067
 Tyr Thr Ser Pro Asn Val Arg Ser Leu Met Pro His Tyr Gln Arg Met
             935                 940                 945

 cat ccc acg gtg aag atc aac aac gcg atg ata ttt tca agc tat gtc     3115
 His Pro Thr Val Lys Ile Asn Asn Ala Met Ile Phe Ser Ser Tyr Val
         950                 955                 960

 gtg gag cag cag gaa ggg ctg aat aca gaa tcc cag acc ctg agg gag     3163
 Val Glu Gln Gln Glu Gly Leu Asn Thr Glu Ser Gln Thr Leu Arg Glu
     965                 970                 975

 att ctg aat tcg gct ccc aag aac atg gcg act tcc aca cct gtg gct     3211
 Ile Leu Asn Ser Ala Pro Lys Asn Met Ala Thr Ser Thr Pro Val Ala
 980                 985                 990                 995

 cgt ggt ggt ggt ttg cca gct acg ttc aac aaa aac act cct aag acc     3259
 Arg Gly Gly Gly Leu Pro Ala Thr Phe Asn Lys Asn Thr Pro Lys Thr
                1000                1005                1010

 ttt act cct gaa tgt gaa aat cag aag gac cct ttg gtc aac act gtt     3307
 Phe Thr Pro Glu Cys Glu Asn Gln Lys Asp Pro Leu Val Asn Thr Val
            1015                1020                1025

 gtt gtt tat gat tgt gat gtt tgt tcg ttt gca agc ccc aac atg cat     3355
 Val Val Tyr Asp Cys Asp Val Cys Ser Phe Ala Ser Pro Asn Met His
        1030                1035                1040

 tct gtc ttg gtt cat tat cag aag aaa cac ccc gaa gaa aag gct tcc     3403
 Ser Val Leu Val His Tyr Gln Lys Lys His Pro Glu Glu Lys Ala Ser
    1045                1050                1055

 tac ttt agg atc cag aaa act atg cga atg gtg tct gtg gac agg ggc     3451
 Tyr Phe Arg Ile Gln Lys Thr Met Arg Met Val Ser Val Asp Arg Gly
1060                1065                1070                1075

 tct gcc ctt tct caa tta tca ttt gag gtg ggt gct cca atg tct ccc     3499
 Ser Ala Leu Ser Gln Leu Ser Phe Glu Val Gly Ala Pro Met Ser Pro
                1080                1085                1090

 aaa atg tcc aac atg ggt tcc cca ccc ccc cca caa ccc ccg cca cca     3547
 Lys Met Ser Asn Met Gly Ser Pro Pro Pro Pro Gln Pro Pro Pro Pro
            1095                1100                1105

 gac ctc agt act gag ctt tac tac tgc aaa cac tgt tcc tac agc aat     3595
 Asp Leu Ser Thr Glu Leu Tyr Tyr Cys Lys His Cys Ser Tyr Ser Asn
        1110                1115                1120

 cgg tca gtt gtg gga gtg ctt gtc cac tac cag aaa aga cac cca gaa     3643
 Arg Ser Val Val Gly Val Leu Val His Tyr Gln Lys Arg His Pro Glu
    1125                1130                1135

 ata aag gtt act gcc aaa tat atc aga cag gct cct ccc aca gct gca     3691
 Ile Lys Val Thr Ala Lys Tyr Ile Arg Gln Ala Pro Pro Thr Ala Ala
1140                1145                1150                1155

 atg atg aga ggg gtc gaa ggg ccc caa ggc tcc ccc cgg cca ccc gcc     3739
 Met Met Arg Gly Val Glu Gly Pro Gln Gly Ser Pro Arg Pro Pro Ala
                1160                1165                1170

 ccc ata caa cag ctg aac cga agc agc tct gag aga gat ggc cct cct     3787
 Pro Ile Gln Gln Leu Asn Arg Ser Ser Ser Glu Arg Asp Gly Pro Pro
            1175                1180                1185

 gtg gag aat gag atg ttc ttt tgc cag cac tgt gat tat ggg aac cgg     3835
 Val Glu Asn Glu Met Phe Phe Cys Gln His Cys Asp Tyr Gly Asn Arg
        1190                1195                1200

 acg gtc aaa ggg gta ctc att cat tat cag aag aag cac cga gac ttc     3883
 Thr Val Lys Gly Val Leu Ile His Tyr Gln Lys Lys His Arg Asp Phe
    1205                1210                1215

 aag gcc aat gca gat gtg atc cgg cag cat acg gcc acc att cga agc     3931
 Lys Ala Asn Ala Asp Val Ile Arg Gln His Thr Ala Thr Ile Arg Ser
1220                1225                1230                1235

 ctc tgc gac cga aat cag aag aag cct gcc agc tgc gtg ctt gtc tcc     3979
 Leu Cys Asp Arg Asn Gln Lys Lys Pro Ala Ser Cys Val Leu Val Ser
                1240                1245                1250

 ccc tct aat ctg gag cgg gac aaa acg aaa ctc cga gca ctc aaa tgt     4027
 Pro Ser Asn Leu Glu Arg Asp Lys Thr Lys Leu Arg Ala Leu Lys Cys
            1255                1260                1265

 agg cag tgc tca tat acc tcc ccc tac ttc tat gca ctg agg aag cat     4075
 Arg Gln Cys Ser Tyr Thr Ser Pro Tyr Phe Tyr Ala Leu Arg Lys His
        1270                1275                1280

 atc aag aaa gac cac ccc gcc ctg aaa gcc aca gtc acg tcc atc atg     4123
 Ile Lys Lys Asp His Pro Ala Leu Lys Ala Thr Val Thr Ser Ile Met
    1285                1290                1295

 cga tgg gca ttt cta gat ggc ttg ata gaa gct ggc tac cac tgc gag     4171
 Arg Trp Ala Phe Leu Asp Gly Leu Ile Glu Ala Gly Tyr His Cys Glu
1300                1305                1310                1315

 tgg tgc atc tac tcc cat acg gag ccc aac ggt ttg ctc ctg cat tac     4219
 Trp Cys Ile Tyr Ser His Thr Glu Pro Asn Gly Leu Leu Leu His Tyr
                1320                1325                1330

 caa cgg agg cat cca gaa cac tat gtt gat tac acc tac atg gct act     4267
 Gln Arg Arg His Pro Glu His Tyr Val Asp Tyr Thr Tyr Met Ala Thr
            1335                1340                1345

 aaa ctg tgg gct ggg cca gac cca tcc cct ccc tct ctc aca atg cca     4315
 Lys Leu Trp Ala Gly Pro Asp Pro Ser Pro Pro Ser Leu Thr Met Pro
        1350                1355                1360

 gcc gaa gcc aaa acc tac aga tgc agg gac tgt gtt ttc gaa gct gtt     4363
 Ala Glu Ala Lys Thr Tyr Arg Cys Arg Asp Cys Val Phe Glu Ala Val
    1365                1370                1375

 tcc atc tgg gac acc act aat cac tac caa gca ttc cac ccc tgg gcc     4411
 Ser Ile Trp Asp Thr Thr Asn His Tyr Gln Ala Phe His Pro Trp Ala
1380                1385                1390                1395

 atg aat ggt gat gag tca gtg cta ctg gac atc atc aag gag aaa gat     4459
 Met Asn Gly Asp Glu Ser Val Leu Leu Asp Ile Ile Lys Glu Lys Asp
                1400                1405                1410

 gct gtg gag aag ccc att ctt tca tcc gaa gag ttg gca ggc cct gtg     4507
 Ala Val Glu Lys Pro Ile Leu Ser Ser Glu Glu Leu Ala Gly Pro Val
            1415                1420                1425

 aat tgt gaa aac agt ata ccc acc cct ttc ccg gag cag gaa gct gaa     4555
 Asn Cys Glu Asn Ser Ile Pro Thr Pro Phe Pro Glu Gln Glu Ala Glu
        1430                1435                1440

 tgt cca gag gat gca aga ctg tcc cct gag aaa agc ctg cag cta gct     4603
 Cys Pro Glu Asp Ala Arg Leu Ser Pro Glu Lys Ser Leu Gln Leu Ala
    1445                1450                1455

 tca gcc aac ccc gcc ata tcc tcc acc cca tac cag tgc acg gta tgc     4651
 Ser Ala Asn Pro Ala Ile Ser Ser Thr Pro Tyr Gln Cys Thr Val Cys
1460                1465                1470                1475

 caa tct gag tat aac aac ttg cac ggc ctt ctc act cat tat ggg aag     4699
 Gln Ser Glu Tyr Asn Asn Leu His Gly Leu Leu Thr His Tyr Gly Lys
                1480                1485                1490

 aag cac cct ggc atg aaa gtg aag gct gct gac ttt gcc cag gac att     4747
 Lys His Pro Gly Met Lys Val Lys Ala Ala Asp Phe Ala Gln Asp Ile
            1495                1500                1505

 gac atc aac cca ggt gcc gtc tac aaa tgc agg cat tgc cca tac atc     4795
 Asp Ile Asn Pro Gly Ala Val Tyr Lys Cys Arg His Cys Pro Tyr Ile
        1510                1515                1520

 aac acc cgc atc cac ggc gta ctg acc cac tac cag aag cga cac ccg     4843
 Asn Thr Arg Ile His Gly Val Leu Thr His Tyr Gln Lys Arg His Pro
    1525                1530                1535

 tcc atc aag gtg acc gct gag gac ttt gtg cac gac gta gag cag tct     4891
 Ser Ile Lys Val Thr Ala Glu Asp Phe Val His Asp Val Glu Gln Ser
1540                1545                1550                1555

 gct gac ata tcc cag aat gac gtg gag gag acg agc agg atc ttc aag     4939
 Ala Asp Ile Ser Gln Asn Asp Val Glu Glu Thr Ser Arg Ile Phe Lys
                1560                1565                1570

 caa ggg tat ggc gcc tac cgg tgc aaa ctg tgt ccg tac aca cac ggc     4987
 Gln Gly Tyr Gly Ala Tyr Arg Cys Lys Leu Cys Pro Tyr Thr His Gly
            1575                1580                1585

 act ttg gag aaa cta aaa atc cac tac gag aag tat cac aat cag cct     5035
 Thr Leu Glu Lys Leu Lys Ile His Tyr Glu Lys Tyr His Asn Gln Pro
        1590                1595                1600

 gaa ttt gat gtc ttt tcc cag tcg ccc ccg aag ctg cca gtc ccc ctc     5083
 Glu Phe Asp Val Phe Ser Gln Ser Pro Pro Lys Leu Pro Val Pro Leu
    1605                1610                1615

 gag ccc gag atg acc act gaa gtg agc cct tcc caa gtc tcc atc act     5131
 Glu Pro Glu Met Thr Thr Glu Val Ser Pro Ser Gln Val Ser Ile Thr
1620                1625                1630                1635

 gag gag gag gtg gga gag gag ccc gtg tcc act tct cac ttc tct acc     5179
 Glu Glu Glu Val Gly Glu Glu Pro Val Ser Thr Ser His Phe Ser Thr
                1640                1645                1650

 tcc cac ctg gtc tcc cac act gtg ttc cgg tgc cag ctc tgc aag tac     5227
 Ser His Leu Val Ser His Thr Val Phe Arg Cys Gln Leu Cys Lys Tyr
            1655                1660                1665

 ttc tgc tcc acg agg aag ggg atc gcc agg cac tac cgc atc aag cac     5275
 Phe Cys Ser Thr Arg Lys Gly Ile Ala Arg His Tyr Arg Ile Lys His
        1670                1675                1680

 aat aat gtc cga gcc cag cca gaa ggc aag aac aac ctc ttc aag tgt     5323
 Asn Asn Val Arg Ala Gln Pro Glu Gly Lys Asn Asn Leu Phe Lys Cys
    1685                1690                1695

 gcc ctg tgt gcc tac acc aac ccc atc cgc aaa ggt ctg gca gcc cac     5371
 Ala Leu Cys Ala Tyr Thr Asn Pro Ile Arg Lys Gly Leu Ala Ala His
1700                1705                1710                1715

 tac cag aag cgc cac gac att gat gcg tat tac act cac tgc ttg gca     5419
 Tyr Gln Lys Arg His Asp Ile Asp Ala Tyr Tyr Thr His Cys Leu Ala
                1720                1725                1730

 gcc tcc agg acc atc agc gac aag ccc aac aaa gtg atc atc cca tcc     5467
 Ala Ser Arg Thr Ile Ser Asp Lys Pro Asn Lys Val Ile Ile Pro Ser
            1735                1740                1745

 ccg ccc aag gac gac tcc cct cag ctg agc gag gaa ctc cgg cgg gca     5515
 Pro Pro Lys Asp Asp Ser Pro Gln Leu Ser Glu Glu Leu Arg Arg Ala
        1750                1755                1760

 gtg gag aag aaa aag tgc tcc ttg tgc tct ttc cag tcg ttc agc aag     5563
 Val Glu Lys Lys Lys Cys Ser Leu Cys Ser Phe Gln Ser Phe Ser Lys
    1765                1770                1775

 aag ggc atc gtg tcc cat tac atg aaa cgc cac cca ggg gtg ttc cca     5611
 Lys Gly Ile Val Ser His Tyr Met Lys Arg His Pro Gly Val Phe Pro
1780                1785                1790                1795

 aag aag cag cac gcc agc aag ttg ggg ggc tac ttc acg gcc gtc tat     5659
 Lys Lys Gln His Ala Ser Lys Leu Gly Gly Tyr Phe Thr Ala Val Tyr
                1800                1805                1810

 gca gat gag cat gag aag ccc aca ctg atg gaa gaa gag gag aga ggc     5707
 Ala Asp Glu His Glu Lys Pro Thr Leu Met Glu Glu Glu Glu Arg Gly
            1815                1820                1825

 aac ttt gag aaa gcc gag gtg gag ggt gaa gct cag gaa atc gag tgg     5755
 Asn Phe Glu Lys Ala Glu Val Glu Gly Glu Ala Gln Glu Ile Glu Trp
        1830                1835                1840

 ctc cca ttc cgc tgc atc aaa tgc ttc aag ctg tcc ttt agc act gca     5803
 Leu Pro Phe Arg Cys Ile Lys Cys Phe Lys Leu Ser Phe Ser Thr Ala
    1845                1850                1855

 gag ctg ctg tgc atg cat tac act gac cac cac agt cgg gac cta aag     5851
 Glu Leu Leu Cys Met His Tyr Thr Asp His His Ser Arg Asp Leu Lys
1860                1865                1870                1875

 agg gac ttc atc att ctg ggc aac ggc ccc cgc ttg cag aac tcc acc     5899
 Arg Asp Phe Ile Ile Leu Gly Asn Gly Pro Arg Leu Gln Asn Ser Thr
                1880                1885                1890

 tac cag tgt aag cac tgt gat agc aaa ctg caa agc aca gcc gag ctg     5947
 Tyr Gln Cys Lys His Cys Asp Ser Lys Leu Gln Ser Thr Ala Glu Leu
            1895                1900                1905

 acc tca cac ttg aac att cac aat gag gaa ttc cag aag cgt gcc aaa     5995
 Thr Ser His Leu Asn Ile His Asn Glu Glu Phe Gln Lys Arg Ala Lys
        1910                1915                1920

 cgt cag gag agg agg aaa cag ctt ttg agc aag cag aaa tat gca gat     6043
 Arg Gln Glu Arg Arg Lys Gln Leu Leu Ser Lys Gln Lys Tyr Ala Asp
    1925                1930                1935

 ggt gct ttt gca gat ttc aaa caa gag agg cct ttt ggt cac tta gaa     6091
 Gly Ala Phe Ala Asp Phe Lys Gln Glu Arg Pro Phe Gly His Leu Glu
1940                1945                1950                1955

 gag gtg cca aag atc aag gag agg aaa gtg gtg ggc tac aaa tgt aaa     6139
 Glu Val Pro Lys Ile Lys Glu Arg Lys Val Val Gly Tyr Lys Cys Lys
                1960                1965                1970

 ttc tgt gtg gaa gtg cac cca acg ctc cga gcc atc tgc aat cac ctc     6187
 Phe Cys Val Glu Val His Pro Thr Leu Arg Ala Ile Cys Asn His Leu
            1975                1980                1985

 cga aag cac gtc cag tat ggc aat gtc cca gct gtg tca gct gct gtg     6235
 Arg Lys His Val Gln Tyr Gly Asn Val Pro Ala Val Ser Ala Ala Val
        1990                1995                2000

 aag gag gcg gat gac cct gcc cac ttg ttc ctg gat gga ttg gaa gca     6283
 Lys Glu Ala Asp Asp Pro Ala His Leu Phe Leu Asp Gly Leu Glu Ala
    2005                2010                2015

 gcc aaa gac gcc agt ggc gcc ctg gtg ggc cgg gtg gat ggt gaa cac     6331
 Ala Lys Asp Ala Ser Gly Ala Leu Val Gly Arg Val Asp Gly Glu His
2020                2025                2030                2035

 tgc ttg ctt gat gga atg ttg gag gat gaa acc cgg ccg ggg gga tac     6379
 Cys Leu Leu Asp Gly Met Leu Glu Asp Glu Thr Arg Pro Gly Gly Tyr
                2040                2045                2050

 cat tgc agt caa tgt gac aga gtc ctg atg tcc atg cag ggg ctg cgt     6427
 His Cys Ser Gln Cys Asp Arg Val Leu Met Ser Met Gln Gly Leu Arg
            2055                2060                2065

 tct cat gag agg agc cac ctg gcc ctg gcc atg ttt acc cgc gag gac     6475
 Ser His Glu Arg Ser His Leu Ala Leu Ala Met Phe Thr Arg Glu Asp
        2070                2075                2080

 aag tac agc tgc cag tat tgc tcg ttt gtt tct gct ttc agg cac aat     6523
 Lys Tyr Ser Cys Gln Tyr Cys Ser Phe Val Ser Ala Phe Arg His Asn
    2085                2090                2095

 ttg gat cgc cat atg caa acc cac cac gga cac cat aaa cca ttc cga     6571
 Leu Asp Arg His Met Gln Thr His His Gly His His Lys Pro Phe Arg
2100                2105                2110                2115

 tgc aaa ctc tgc tcc ttc aag tcc tcc tat aac agc cgg ctg aaa aca     6619
 Cys Lys Leu Cys Ser Phe Lys Ser Ser Tyr Asn Ser Arg Leu Lys Thr
                2120                2125                2130

 cat ata ctc aaa gct cat gct ggt gag cat gcc tac aag tgt tct tgg     6667
 His Ile Leu Lys Ala His Ala Gly Glu His Ala Tyr Lys Cys Ser Trp
            2135                2140                2145

 tgc tca ttc tcc acc atg aca atc agc cag ctg aag gaa cac tcc ctc     6715
 Cys Ser Phe Ser Thr Met Thr Ile Ser Gln Leu Lys Glu His Ser Leu
        2150                2155                2160

 aag gtc cac gga aaa gcc ctg acc ctc ccc agg cca cgg atc gtc agt     6763
 Lys Val His Gly Lys Ala Leu Thr Leu Pro Arg Pro Arg Ile Val Ser
    2165                2170                2175

 ctc ctc tcc tca cac tcc cac cac tcc tcc caa aaa gct acc ccg gct     6811
 Leu Leu Ser Ser His Ser His His Ser Ser Gln Lys Ala Thr Pro Ala
2180                2185                2190                2195

 gaa gaa gtg gaa gac tcc aat gac tca tca tat tca gag ccc cca gat     6859
 Glu Glu Val Glu Asp Ser Asn Asp Ser Ser Tyr Ser Glu Pro Pro Asp
                2200                2205                2210

 gtt cag cag cag ttg aac cac tat cag tca gct gcc ctg gca agg aac     6907
 Val Gln Gln Gln Leu Asn His Tyr Gln Ser Ala Ala Leu Ala Arg Asn
            2215                2220                2225

 aac agc cgt gtt agc cct gtg cct ctt tct ggg gct gct gct ggc act     6955
 Asn Ser Arg Val Ser Pro Val Pro Leu Ser Gly Ala Ala Ala Gly Thr
        2230                2235                2240

 gag cag aaa act gaa gcc gtg ctt cac tgc gaa ttc tgt gaa ttc tcc     7003
 Glu Gln Lys Thr Glu Ala Val Leu His Cys Glu Phe Cys Glu Phe Ser
    2245                2250                2255

 tcc ggc tac atc cag agc atc agg cgt cat tac cgg gac aag cat ggt     7051
 Ser Gly Tyr Ile Gln Ser Ile Arg Arg His Tyr Arg Asp Lys His Gly
2260                2265                2270                2275

 ggg aag aag ctt ttc aag tgc aaa gac tgc tcc ttt tac aca ggc ttt     7099
 Gly Lys Lys Leu Phe Lys Cys Lys Asp Cys Ser Phe Tyr Thr Gly Phe
                2280                2285                2290

 aaa tct gct ttt act atg cac gtg gaa gct ggg cac tca gca gtt ccc     7147
 Lys Ser Ala Phe Thr Met His Val Glu Ala Gly His Ser Ala Val Pro
            2295                2300                2305

 gag gag ggc ccc aaa gat ctt cgc tgt cct ctc tgc ctc tat cac acc     7195
 Glu Glu Gly Pro Lys Asp Leu Arg Cys Pro Leu Cys Leu Tyr His Thr
        2310                2315                2320

 aaa tac aag cgc aac atg att gac cac atc gtg ctg cac cga gaa gag     7243
 Lys Tyr Lys Arg Asn Met Ile Asp His Ile Val Leu His Arg Glu Glu
    2325                2330                2335

 cgt gtt gtc ccc att gaa gtt tgc cgg tcc aaa ctg tcc aaa tac ttg     7291
 Arg Val Val Pro Ile Glu Val Cys Arg Ser Lys Leu Ser Lys Tyr Leu
2340                2345                2350                2355

 cag gga gta gtt ttc cgc tgt gat aag tgt acc ttc acc tgc tcc agt     7339
 Gln Gly Val Val Phe Arg Cys Asp Lys Cys Thr Phe Thr Cys Ser Ser
                2360                2365                2370

 gat gag agc ctc cag caa cat ata gaa aag cac aat gaa ctg aaa cct     7387
 Asp Glu Ser Leu Gln Gln His Ile Glu Lys His Asn Glu Leu Lys Pro
            2375                2380                2385

 tac aaa tgc cag ctc tgc tac tat gag acc aag cac acg gag gaa ctg     7435
 Tyr Lys Cys Gln Leu Cys Tyr Tyr Glu Thr Lys His Thr Glu Glu Leu
        2390                2395                2400

 gac agc cac ctt cgg gat gag cat aag gta agc cgt aac ttt gag ctg     7483
 Asp Ser His Leu Arg Asp Glu His Lys Val Ser Arg Asn Phe Glu Leu
    2405                2410                2415

 gtt gga cgg gtt aac ttg gat cag ctg gaa cag atg aag gag aaa atg     7531
 Val Gly Arg Val Asn Leu Asp Gln Leu Glu Gln Met Lys Glu Lys Met
2420                2425                2430                2435

 gag agc tcc agc agc gat gat gag gac aag gaa gaa gaa atg aac agc     7579
 Glu Ser Ser Ser Ser Asp Asp Glu Asp Lys Glu Glu Glu Met Asn Ser
                2440                2445                2450

 aag gct gaa gac aga gag ctg atg aga ttt tct gac cac ggg gct gct     7627
 Lys Ala Glu Asp Arg Glu Leu Met Arg Phe Ser Asp His Gly Ala Ala
            2455                2460                2465

 ctt aac act gag aag cgt ttt cca tgt gaa ttt tgt gga cgg gcg ttt     7675
 Leu Asn Thr Glu Lys Arg Phe Pro Cys Glu Phe Cys Gly Arg Ala Phe
        2470                2475                2480

 tca cag ggc tct gag tgg gaa aga cat gtg ctg aga cac ggc atg gca     7723
 Ser Gln Gly Ser Glu Trp Glu Arg His Val Leu Arg His Gly Met Ala
    2485                2490                2495

 ttg aat gac acc aag cag gtg agc aga gaa gaa atc cac cca aaa gag     7771
 Leu Asn Asp Thr Lys Gln Val Ser Arg Glu Glu Ile His Pro Lys Glu
2500                2505                2510                2515

 atc atg gag aac agt gtt aaa atg ccc tcc ata gag gaa aag gaa gat     7819
 Ile Met Glu Asn Ser Val Lys Met Pro Ser Ile Glu Glu Lys Glu Asp
                2520                2525                2530

 gac gag gcc att ggg ata gac ttt tcc cta aag aat gaa aca gta gcc     7867
 Asp Glu Ala Ile Gly Ile Asp Phe Ser Leu Lys Asn Glu Thr Val Ala
            2535                2540                2545

 atc tgt gta gta act gcc gac aaa tct ctc ctg gag aat gca gag gcc     7915
 Ile Cys Val Val Thr Ala Asp Lys Ser Leu Leu Glu Asn Ala Glu Ala
        2550                2555                2560

 aaa aaa gaa tga gcg tttggtgaaa ttcttaatca aaccttactt gaacagtgat     7970
 Lys Lys Glu 
    2565

 gaaaaagtgg gagggctggc tttggctgag aagggaggga cagaaaagag aagacagaac   8030

 aaagctgctt tttaggactg aacaatctat tttcaaagca ctggtacctg tgtgagtgag   8090

 tatgtaaatt aaagttattt aaatggttgg aatatgtggc tccttttcca tcactacatc   8150

 ttttcttccg gatcttcatc atggaagttt catttgttgc ggaatatgga agcacctccc   8210

 aatggtacgg tgcaccctgt ggtggtcttg gacagtatgt ggaaacagaa gctccatgac   8270

 ggtagaagac ttctcattgg ggagcaactt ttttacgcac aacttttggt gcgtttttct   8330

 agttttaata ccttaagctt tttcaagacc taactgcagc cgctttggga aaaaaaaaca   8390

 aaaaacaaaa aacag                                                    8405




      <210> 294
      <211> 577
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (50)..(448)

      <400> 294
 gcaaggcatt ggcagcctga gctattttgg gacactttct ctgctgtgg    atg cca      55
                                                          Met Pro
                                                            1

 ctt ttg gaa tac gcc agg aac atg cta agg acc tgg agc tct cta ccc      103
 Leu Leu Glu Tyr Ala Arg Asn Met Leu Arg Thr Trp Ser Ser Leu Pro
           5                  10                  15

 tgg acc cgt ttt cgg gtt tgc ttg ctc tct ctc tct ctc ttt ctc tgg      151
 Trp Thr Arg Phe Arg Val Cys Leu Leu Ser Leu Ser Leu Phe Leu Trp
      20                  25                  30

 gct aat cgt tta gag gac agt cgc tcc tgc caa cct aat ccc atg agc      199
 Ala Asn Arg Leu Glu Asp Ser Arg Ser Cys Gln Pro Asn Pro Met Ser
  35                  40                  45                  50

 ctg act acc ttg ccg ggc cac agg ctc aaa gaa gca gtg tgg ctg cca      247
 Leu Thr Thr Leu Pro Gly His Arg Leu Lys Glu Ala Val Trp Leu Pro
                  55                  60                  65

 gca ccc tca cgc acc atg agt cct cac ctt gac cct aat caa ctt ggg      295
 Ala Pro Ser Arg Thr Met Ser Pro His Leu Asp Pro Asn Gln Leu Gly
              70                  75                  80

 att ctc ctc aaa gta ctt aga aag gaa aag gaa gac ggt gac tac cct      343
 Ile Leu Leu Lys Val Leu Arg Lys Glu Lys Glu Asp Gly Asp Tyr Pro
          85                  90                  95

 gac atg atg gcc acc cac ccg agc tcc agg tat gaa gcc tgc tcc tct      391
 Asp Met Met Ala Thr His Pro Ser Ser Arg Tyr Glu Ala Cys Ser Ser
     100                 105                 110

 gga att act cta ggt atg ttt act tta ttc ttt cat cat ttt aac aaa      439
 Gly Ile Thr Leu Gly Met Phe Thr Leu Phe Phe His His Phe Asn Lys
 115                 120                 125                 130

 tat gta taa ggctgct gcccacagga acttaaaaat attcagccgc catgtctcac      495
 Tyr Val 


 gcataggtaa ggaattcata tctcttctta cataaccaac aaagcaaatg cagcttaagt    555

 acagcctgga aaaaaaaaaa aa                                             577




      <210> 295
      <211> 665
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (50)..(274)

      <400> 295
 gcaaggcatt ggcagcctga gctattttgg gacactttct ctgctgtgg    atg cca      55
                                                          Met Pro
                                                            1

 ctt ttg gaa tac gcc agg aac atg cta agg acc tgg agc tct cta ccc      103
 Leu Leu Glu Tyr Ala Arg Asn Met Leu Arg Thr Trp Ser Ser Leu Pro
           5                  10                  15

 tgg acc cgt ttt cgg gtt tgc ttg ctc tct ctc tct ctc ttt ctc tgg      151
 Trp Thr Arg Phe Arg Val Cys Leu Leu Ser Leu Ser Leu Phe Leu Trp
      20                  25                  30

 gct aat cgt tta gag gac agt cgc tcc tgc caa cct aat ccc atg agc      199
 Ala Asn Arg Leu Glu Asp Ser Arg Ser Cys Gln Pro Asn Pro Met Ser
  35                  40                  45                  50

 ctg act acc ttg ccg ggc cac agg ctc aaa gaa gca gtg tgg ctg cca      247
 Leu Thr Thr Leu Pro Gly His Arg Leu Lys Glu Ala Val Trp Leu Pro
                  55                  60                  65

 gca ccc tca cgg atc atc act tcc taa tctga tgcaactgac tcggcaggca      299
 Ala Pro Ser Arg Ile Ile Thr Ser 
              70

 ttcgggagcc tgtaagctcc attttcctgt tccaaattct tctgcacctc accatgagtc    359

 ctcaccttga ccctaatcaa cttgggattc tcctcaaagt acttagaaag gaaaaggaag    419

 ccggtgccta ccctgacatg atggccaccc acccgagctc caggtatgaa gcctgctcct    479

 ctggaattac tctaggtatg tttactttat tctttcatca ttttaacaaa tatgtataag    539

 gctgctgccc acaggaactt aaaaatattc agccgccatg tctcacgcat aggtaaggaa    599

 ttcatatctc ttcttacata accaacaaag caaatgcagc ttaagtacag cctggaaaaa    659

 aaaaaa                                                               665




      <210> 296
      <211> 1973
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(1386)

      <400> 296
 cgccgctctc cggccctcgc cctgtccgcc gccaccgccg ccgccgccag agtcgcc        57                                                                 
 atg cag atc ccg cgc gcc gct ctt ctc ccg ctg ctg ctg ctg ctg ctg      105
 Met Gln Ile Pro Arg Ala Ala Leu Leu Pro Leu Leu Leu Leu Leu Leu
   1               5                  10                  15

 gcg gcg ccc gcc cgg gac gcg tgc ggg tgc tgc gag gtg tgc ggc gcg      153
 Ala Ala Pro Ala Arg Asp Ala Cys Gly Cys Cys Glu Val Cys Gly Ala
              20                  25                  30

 ccc gag ggc gcc gcg tgc ggc ctg cag gag ggc ccg tgc ggc gag ggg      201
 Pro Glu Gly Ala Ala Cys Gly Leu Gln Glu Gly Pro Cys Gly Glu Gly
          35                  40                  45

 ctg cag tgc gtg gtg ccc ttc ggg gtg cca gcc tcg gcc acg gtg cgg      249
 Leu Gln Cys Val Val Pro Phe Gly Val Pro Ala Ser Ala Thr Val Arg
      50                  55                  60

 cgg cgc gcg cag gcc ggc ctc tgt gtg tgc gcc agc agc gag ccg gtg      297
 Arg Arg Ala Gln Ala Gly Leu Cys Val Cys Ala Ser Ser Glu Pro Val
  65                  70                  75                  80

 tgc ggc agc gac gcc aac acc tac gcc aac ctg tgc cag ctg cgc gcc      345
 Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn Leu Cys Gln Leu Arg Ala
                  85                  90                  95

 gcc agc cgc cgc tcc gag agg ctg cac cgg ccg ccg gtc atc gtc ctg      393
 Ala Ser Arg Arg Ser Glu Arg Leu His Arg Pro Pro Val Ile Val Leu
             100                 105                 110

 cag cgc gga gcc tgc ggc caa ggg cag gaa gat ccc aac agt ttg cgc      441
 Gln Arg Gly Ala Cys Gly Gln Gly Gln Glu Asp Pro Asn Ser Leu Arg
         115                 120                 125

 cat aaa tat aac ttt atc gcg gac gtg gtg gag aag atc gcc cct gcc      489
 His Lys Tyr Asn Phe Ile Ala Asp Val Val Glu Lys Ile Ala Pro Ala
     130                 135                 140

 gtg gtt cat atc gaa ttg ttt cgc aag ctt ccg ttt tct aaa cga gag      537
 Val Val His Ile Glu Leu Phe Arg Lys Leu Pro Phe Ser Lys Arg Glu
 145                 150                 155                 160

 gtg ccg gtg gct agt ggg tct ggg ttt att gtg tcg gaa gat gga ctg      585
 Val Pro Val Ala Ser Gly Ser Gly Phe Ile Val Ser Glu Asp Gly Leu
                 165                 170                 175

 atc gtg aca aat gcc cac gtg gtg acc aac aag cac cgg gtc aaa gtt      633
 Ile Val Thr Asn Ala His Val Val Thr Asn Lys His Arg Val Lys Val
             180                 185                 190

 gag ctg aag aac ggt gcc act tac gaa gcc aaa atc aag gat gtg gat      681
 Glu Leu Lys Asn Gly Ala Thr Tyr Glu Ala Lys Ile Lys Asp Val Asp
         195                 200                 205

 gag aaa gca gac atc gca ctc atc aaa att gac cac cag ggc aag ctg      729
 Glu Lys Ala Asp Ile Ala Leu Ile Lys Ile Asp His Gln Gly Lys Leu
     210                 215                 220

 cct gtc ctg ctg ctt ggc cgc tcc tca gag ctg cgg ccg gga gag ttc      777
 Pro Val Leu Leu Leu Gly Arg Ser Ser Glu Leu Arg Pro Gly Glu Phe
 225                 230                 235                 240

 gtg gtc gcc atc gga agc ccg ttt tcc ctt caa aac aca gtc acc acc      825
 Val Val Ala Ile Gly Ser Pro Phe Ser Leu Gln Asn Thr Val Thr Thr
                 245                 250                 255

 ggg atc gtg agc acc acc cag cga ggc ggc aaa gag ctg ggg ctc cgc      873
 Gly Ile Val Ser Thr Thr Gln Arg Gly Gly Lys Glu Leu Gly Leu Arg
             260                 265                 270

 aac tca gac atg gac tac atc cag acc gac gcc atc atc aac tat gga      921
 Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp Ala Ile Ile Asn Tyr Gly
         275                 280                 285

 aac tcg gga ggc ccg tta gta aac ctg gac ggt gaa gtg att gga att      969
 Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Ile
     290                 295                 300

 aac act ttg aaa gtg aca gct gga atc tcc ttt gca atc cca tct gat     1017
 Asn Thr Leu Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp
 305                 310                 315                 320

 aag att aaa aag ttc ctc acg gag tcc cat gac cga cag gcc aaa gga     1065
 Lys Ile Lys Lys Phe Leu Thr Glu Ser His Asp Arg Gln Ala Lys Gly
                 325                 330                 335

 aaa gcc atc acc aag aag aag tat att ggt atc cga atg atg tca ctc     1113
 Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly Ile Arg Met Met Ser Leu
             340                 345                 350

 acg tcc agc aaa gcc aaa gag ctg aag gac cgg cac cgg gac ttc cca     1161
 Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp Arg His Arg Asp Phe Pro
         355                 360                 365

 gac gtg atc tca gga gcg tat ata att gaa gta att cct gat acc cca     1209
 Asp Val Ile Ser Gly Ala Tyr Ile Ile Glu Val Ile Pro Asp Thr Pro
     370                 375                 380

 gca gaa gct ggt ggt ctc aag gaa aac gac gtc ata atc agc atc aat     1257
 Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp Val Ile Ile Ser Ile Asn
 385                 390                 395                 400

 gga cag tcc gtg gtc tcc gcc aat gat gtc agc gac gtc att aaa agg     1305
 Gly Gln Ser Val Val Ser Ala Asn Asp Val Ser Asp Val Ile Lys Arg
                 405                 410                 415

 gaa agc acc ctg aac atg gtg gtc cgc agg ggt aat gaa gat atc atg     1353
 Glu Ser Thr Leu Asn Met Val Val Arg Arg Gly Asn Glu Asp Ile Met
             420                 425                 430

 atc aca gtg att ccc gaa gaa att gac cca tag gcagaggc atgagctgga     1404
 Ile Thr Val Ile Pro Glu Glu Ile Asp Pro 
         435                 440

 cttcatgttt ccctcaaaga ctctcccgtg gatgacggat gaggactctg ggctgctgga   1464

 ataggacact caagactttt gactgccatt ttgtttgttc agtggagact ccctggccaa   1524

 cagaatcctt cttgatagtt tgcaggcaaa acaaatgtaa tgttgcagat ccgcaggcag   1584

 aagctctgcc cttctgtatc ctatgtatgc agtgtgcttt ttcttgccag cttgggccat   1644

 tcttgcttag acagtcagca tttgtctcct cctttaactg agtcatcatc ttagtccaac   1704

 taatgcagtc gatacaatgc gtagatagaa gaagccccac gggagccagg atgggactgg   1764

 tcgtgtttgt gcttttctcc aagtcagcac ccaaaggtca atgcacagag accccgggtg   1824

 ggtgagcgct ggcttctcaa acggccgaag ttgcctcttt taggaatctc tttggaattg   1884

 ggagcacgat gactctgagt ttgagctatt aaagtacttc ttacacattg aaaaaaaaaa   1944

 aaaaaaaaaa aaaaaaaaaa aaaaaaaag                                     1973




      <210> 297
      <211> 1269
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1269)

      <400> 297
  atg agg ggc ctt gtg gta ttc ctt gca gtc ttt gct ctc tct gag gtc      48
  Met Arg Gly Leu Val Val Phe Leu Ala Val Phe Ala Leu Ser Glu Val
    1               5                  10                  15

 aat gcc atc acc agg gtt cct ctg cac aaa ggg aag tcg ctg agg agg       96
 Asn Ala Ile Thr Arg Val Pro Leu His Lys Gly Lys Ser Leu Arg Arg
              20                  25                  30

 gcc ctg aag gag cgc agg ctc ctg gag gac ttc ctg agg aat cac cat      144
 Ala Leu Lys Glu Arg Arg Leu Leu Glu Asp Phe Leu Arg Asn His His
          35                  40                  45

 tat gca gtc agc agg aag cac tcc agc tct ggg gtg gtg gcc agc gag      192
 Tyr Ala Val Ser Arg Lys His Ser Ser Ser Gly Val Val Ala Ser Glu
      50                  55                  60

 tct ctg acc aac tac ctg gat tgt cag tac ttt ggg aag atc tac atc      240
 Ser Leu Thr Asn Tyr Leu Asp Cys Gln Tyr Phe Gly Lys Ile Tyr Ile
  65                  70                  75                  80

 ggg acc ctt ccc cag aag ttc acc ttg gtg ttt gat aca ggc tcc ccg      288
 Gly Thr Leu Pro Gln Lys Phe Thr Leu Val Phe Asp Thr Gly Ser Pro
                  85                  90                  95

 gat atc tgg gtg ccc tct gtc tac tgc aac agt gat gcc tgt cag aga      336
 Asp Ile Trp Val Pro Ser Val Tyr Cys Asn Ser Asp Ala Cys Gln Arg
             100                 105                 110

 att gcc agt att gag gcc ata ttc tta caa ggc ctg ctg agg ggt tcg      384
 Ile Ala Ser Ile Glu Ala Ile Phe Leu Gln Gly Leu Leu Arg Gly Ser
         115                 120                 125

 gcc ctg gct ggc acc gtg agt ggt gag aag att cta agg gcc cca cta      432
 Ala Leu Ala Gly Thr Val Ser Gly Glu Lys Ile Leu Arg Ala Pro Leu
     130                 135                 140

 act ctg ggt ctg tgt ttc aga aaa cca cca acg ctt cga tcc gtc caa      480
 Thr Leu Gly Leu Cys Phe Arg Lys Pro Pro Thr Leu Arg Ser Val Gln
 145                 150                 155                 160

 gtc ctc cac cca cag aac atg ggc aag tcc ctg tcc atc cag tat ggc      528
 Val Leu His Pro Gln Asn Met Gly Lys Ser Leu Ser Ile Gln Tyr Gly
                 165                 170                 175

 aca ggc agc atg cgg ggc ttg ctg ggc tat gac act gtc acc gac cta      576
 Thr Gly Ser Met Arg Gly Leu Leu Gly Tyr Asp Thr Val Thr Asp Leu
             180                 185                 190

 gtg gag gtc atg att ctc ttg cag gtc tcc aac att gtg gac ccc cac      624
 Val Glu Val Met Ile Leu Leu Gln Val Ser Asn Ile Val Asp Pro His
         195                 200                 205

 cag act gtg ggt ctg agc acc cag gaa cct ggc gac gtc ttc acc tac      672
 Gln Thr Val Gly Leu Ser Thr Gln Glu Pro Gly Asp Val Phe Thr Tyr
     210                 215                 220

 tcc gag ttt gat ggg atc ctg ggg ctg gcc tat ccc tct ctt gcc tct      720
 Ser Glu Phe Asp Gly Ile Leu Gly Leu Ala Tyr Pro Ser Leu Ala Ser
 225                 230                 235                 240

 gag aat gac cag ggg agc atg ctc acg ctg agg gcc att gat ctg tcg      768
 Glu Asn Asp Gln Gly Ser Met Leu Thr Leu Arg Ala Ile Asp Leu Ser
                 245                 250                 255

 tac tac aca ggc tcc ctg cac tgg ata ccc atg act gca aga ata ctg      816
 Tyr Tyr Thr Gly Ser Leu His Trp Ile Pro Met Thr Ala Arg Ile Leu
             260                 265                 270

 gca gtt cac tgt gga cag gaa gga cct ggg gag gga ggg ctg gat gag      864
 Ala Val His Cys Gly Gln Glu Gly Pro Gly Glu Gly Gly Leu Asp Glu
         275                 280                 285

 gcc atc ttg cat acc ttt gga agt gtc atc att gac ggc gtg gtg gtg      912
 Ala Ile Leu His Thr Phe Gly Ser Val Ile Ile Asp Gly Val Val Val
     290                 295                 300

 gcc tgt gac ggt ggc tgt cag gcc atc ctg gac acc ggc acc tcc ctg      960
 Ala Cys Asp Gly Gly Cys Gln Ala Ile Leu Asp Thr Gly Thr Ser Leu
 305                 310                 315                 320

 ctg gtg ggg cct ggt ggc aac atc ctc aac atc cag cag gcc att gga     1008
 Leu Val Gly Pro Gly Gly Asn Ile Leu Asn Ile Gln Gln Ala Ile Gly
                 325                 330                 335

 gcc act gcg ggc cag tac aat gag ttt gac atc gac tgc ggg cgc ctg     1056
 Ala Thr Ala Gly Gln Tyr Asn Glu Phe Asp Ile Asp Cys Gly Arg Leu
             340                 345                 350

 agc agc att ccc acg gct gtc ttc gag atc cac ggc aag aag tac ccc     1104
 Ser Ser Ile Pro Thr Ala Val Phe Glu Ile His Gly Lys Lys Tyr Pro
         355                 360                 365

 ctg cca ccc tcc gcc tat acc agc cag gac cag ggc ttc tgc acc agt     1152
 Leu Pro Pro Ser Ala Tyr Thr Ser Gln Asp Gln Gly Phe Cys Thr Ser
     370                 375                 380

 ggt ttc cag ggt gac tat agt tcc cag cag tgg atc ctg ggg aat gtc     1200
 Gly Phe Gln Gly Asp Tyr Ser Ser Gln Gln Trp Ile Leu Gly Asn Val
 385                 390                 395                 400

 ttc atc tgg gag tat tac agt gtc ttt gac agg acc aat aac cgt gtg     1248
 Phe Ile Trp Glu Tyr Tyr Ser Val Phe Asp Arg Thr Asn Asn Arg Val
                 405                 410                 415

 ggg ctg gcg aag gct gtc tga                                         1269
 Gly Leu Ala Lys Ala Val 
             420





      <210> 298
      <211> 3077
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (169)..(666)

      <400> 298
 ggccgggctg cggcagaggc ggcggcggcg ccccgctccg ggtgaggttg ccggggccgt     60

 gcgcgctgat ctgcgagtga agagggacga gggaaaagaa acaaagccac agacgcaact    120

 tgagactccc gcatcccaaa agaagcacca gatcagcaaa aaaagaag atg ggc ccc     177
                                                      Met Gly Pro
                                                        1

 ccg agc ctc gtg ctg tgc ttg ctg tcc gca act gtg ttc tcc ctg ctg      225
 Pro Ser Leu Val Leu Cys Leu Leu Ser Ala Thr Val Phe Ser Leu Leu
       5                  10                  15

 ggt gga agc tcg gcc ttc ctg tcg cac cac cgc ctg aaa ggc agg ttt      273
 Gly Gly Ser Ser Ala Phe Leu Ser His His Arg Leu Lys Gly Arg Phe
  20                  25                  30                  35

 cag agg gac cgc agg aac atc cgc ccc aac atc atc ctg gtg ctg acg      321
 Gln Arg Asp Arg Arg Asn Ile Arg Pro Asn Ile Ile Leu Val Leu Thr
                  40                  45                  50

 gac gac cag gat gtg gag ctg gct ttc ttc ggg aag tat ctt aat gaa      369
 Asp Asp Gln Asp Val Glu Leu Ala Phe Phe Gly Lys Tyr Leu Asn Glu
              55                  60                  65

 tac aac ggc tcc tac gtg cca ccc ggc tgg aag gag tgg gtc gga ctc      417
 Tyr Asn Gly Ser Tyr Val Pro Pro Gly Trp Lys Glu Trp Val Gly Leu
          70                  75                  80

 ctt aaa aac tcc cgc ttt tat aac tac acg ctg tgt cgg aac ggg gtg      465
 Leu Lys Asn Ser Arg Phe Tyr Asn Tyr Thr Leu Cys Arg Asn Gly Val
      85                  90                  95

 aaa gag aag cac ggc tcc gac tac tcc aag cac gcc gag cta caa cta      513
 Lys Glu Lys His Gly Ser Asp Tyr Ser Lys His Ala Glu Leu Gln Leu
 100                 105                 110                 115

 cgc gcc caa ccc gga caa aca ctg gat cat gcg cta cac ggg gcc cat      561
 Arg Ala Gln Pro Gly Gln Thr Leu Asp His Ala Leu His Gly Ala His
                 120                 125                 130

 gaa gcc cat cca cat gga att cac caa cat gct cca gcg gaa gcg ctt      609
 Glu Ala His Pro His Gly Ile His Gln His Ala Pro Ala Glu Ala Leu
             135                 140                 145

 gca gac cct cat gtc ggt gga cga ctc cat gga gac gat tta caa cat      657
 Ala Asp Pro His Val Gly Gly Arg Leu His Gly Asp Asp Leu Gln His
         150                 155                 160

 gct ggt tga gacgggc gagctggaca acacgtacat cgtatacacc gccgaccacg      713
 Ala Gly 
     165

 gttaccacat cggccagttt ggcctggtga aagggaaatc catgccatat gagtttgaca    773

 tcagggtccc gttctacgtg aggggcccca acgtggaagc cggctgtctg aatccccaca    833

 tcgtcctcaa cattgacctg gcccccacca tcctggacat tgcaggcctg gacatacctg    893

 cggatatgga cgggaaatcc atcctcaagc tgctggacac ggagcggccg gtgaatcggt    953

 ttcacttgaa aaagaagatg agggtctggc gggactcctt cttggtggag agaggcaagc   1013

 tgctacacaa gagagacaat gacaaggtgg acgcccagga ggagaacttt ctgcccaagt   1073

 accagcgtgt gaaggacctg tgtcagcgtg ctgagtacca gacggcgtgt gagcagctgg   1133

 gacagaagtg gcagtgtgtg gaggacgcca cggggaagct gaagctgcat aagtgcaagg   1193

 gccccatgcg gctgggcggc agcagagccc tctccaacct cgtgcccaag tactacgggc   1253

 agggcagcga ggcctgcacc tgtgacagcg gggactacaa gctcagcctg gccggacgcc   1313

 ggaaaaaact cttcaagaag aagtacaagg ccagctatgt ccgcagtcgc tccatccgct   1373

 cagtggccat cgaggtggac ggcagggtgt accacgtagg cctgggtgat gccgcccagc   1433

 cccgaaacct caccaagcgg cactggccag gggcccctga ggaccaagat gacaaggatg   1493

 gtggggactt cagtggcact ggaggccttc ccgactactc agccgccaac cccattaaag   1553

 tgacacatcg gtgctacatc ctagagaacg acacagtcca gtgtgacctg gacctgtaca   1613

 agtccctgca ggcctggaaa gaccacaagc tgcacatcga ccacgagatt gaaaccctgc   1673

 agaacaaaat taagaacctg agggaagtcc gaggtcacct gaagaaaaag cggccagaag   1733

 aatgtgactg tcacaaaatc agctaccaca cccagcacaa aggccgcctc aagcacagag   1793

 gctccagtct gcatcctttc aggaagggcc tgcaagagaa ggacaaggtg tggctgttgc   1853

 gggagcagaa gcgcaagaag aaactccgca agctgctcaa gcgcctgcag aacaacgaca   1913

 cgtgcagcat gccaggcctc acgtgcttca cccacgacaa ccagcactgg cagacggcgc   1973

 ctttctggac actggggcct ttctgtgcct gcaccagcgc caacaataac acgtactggt   2033

 gcatgaggac catcaatgag actcacaatt tcctcttctg tgaatttgca actggcttcc   2093

 tagagtactt tgatctcaac acagacccct accagctgat gaatgcagtg aacacactgg   2153

 acagggatgt cctcaaccag ctacacgtac agctcatgga gctgaggagc tgcaagggtt   2213

 acaagcagtg taacccccgg actcgaaaca tggacctggg acttaaagat ggaggaagct   2273

 atgagcaata caggcagttt cagcgtcgaa agtggccaga aatgaagaga ccttcttcca   2333

 aatcactggg acaactgtgg gaaggctggg aaggttaaga aacaacagag gtggacctcc   2393

 aaaaacatag aggcatcacc tgactgcaca ggcaatgaaa aaccatgtgg gtgatttcca   2453

 gcagacctgt gctattggcc aggaggcctg agaaagcaag cacgcactct cagtcaacat   2513

 gacagattct ggaggataac cagcaggagc agagataact tcaggaagtc catttttgcc   2573

 cctgcttttg ctttggatta tacctcacca gctgcacaaa atgcattttt tcgtatcaaa   2633

 aagtcaccac taaccctccc ccagaagctc acaaaggaaa acggagagag cgagcgagag   2693

 agatttcctt ggaaatttct cccaagggcg aaagtcattg gaatttttaa atcatagggg   2753

 aaaagcagtc ctgttctaaa tcctcttatt cttttggttt gtcacaaaga aggaactaag   2813

 aagcaggaca gaggcaacgt ggagaggctg aaaacagtgc agagacgttt gacaatgagt   2873

 cagtagcaca aaagagatga catttaccta gcactataaa ccctggttgc ctctgaagaa   2933

 actgccttca ttgtatatat gtgactattt acatgtaatc aacatgggaa cttttagggg   2993

 aacctaataa gaaatcccaa ttttcaggag tggtggtgtc aataaacgct ctgtggccag   3053

 tgtaaaagaa aaaaaaaaaa aaaa                                          3077




      <210> 299
      <211> 451
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(338)

      <400> 299
 tctttgattt tatattatta ggagcaaaag taaatgaagc ccaggaaaac acctttggga     60

 acaaactctt cctttgatgg aaa    atg cag agg ccc ttc ctc tct gtg ccg     110
                              Met Gln Arg Pro Phe Leu Ser Val Pro
                                1               5

 tgc ttg ctc ctc tta cct gcc cgg gtg gtt tgg ggg tgt tgg tgt ttc      158
 Cys Leu Leu Leu Leu Pro Ala Arg Val Val Trp Gly Cys Trp Cys Phe
  10                  15                  20                  25

 ctc cct gga gaa gat ggg gga ggc tgt ccc act ccc agc tct ggc aga      206
 Leu Pro Gly Glu Asp Gly Gly Gly Cys Pro Thr Pro Ser Ser Gly Arg
                  30                  35                  40

 atc aag ctg ttg cag cag tgc ctt ctt cat cct tcc tta cga tca atc      254
 Ile Lys Leu Leu Gln Gln Cys Leu Leu His Pro Ser Leu Arg Ser Ile
              45                  50                  55

 aca gtc tcc aga aga tca gct caa ttg ctg tgc agg tta aaa cta cag      302
 Thr Val Ser Arg Arg Ser Ala Gln Leu Leu Cys Arg Leu Lys Leu Gln
          60                  65                  70

 aac cac atc cca aag gta cct ggt aag aat gtt tga aaga tcttccattt      352
 Asn His Ile Pro Lys Val Pro Gly Lys Asn Val 
      75                  80

 ctaggaaccc cagtcctgct tctccgcaat ggcacatgct tccactccat ccatactggc    412

 atcctcaaat aaacagatat gtatacataa aaaaaaaaa                           451




      <210> 300
      <211> 1342
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(1218)

      <400> 300
 agtggtaaca acgcagagta acgcggggat tctcaaggac acttgatcca ctgccagaga     60

 ggcccagaat tttctaactt actgtgtggc aga atg aag cct ctg ctt gaa acc     114
                                      Met Lys Pro Leu Leu Glu Thr
                                        1               5

 ctt tat ctt ttg ggg atg ctg gtt cct gga ggg ctg gga tat gat aga      162
 Leu Tyr Leu Leu Gly Met Leu Val Pro Gly Gly Leu Gly Tyr Asp Arg
          10                  15                  20

 tcc tta gcc caa cac aga caa gag att gtg gac aag tca gtg agt cca      210
 Ser Leu Ala Gln His Arg Gln Glu Ile Val Asp Lys Ser Val Ser Pro
      25                  30                  35

 tgg agc ctg gag acg tat tcc tat aac ata tac cac ccc atg gga gag      258
 Trp Ser Leu Glu Thr Tyr Ser Tyr Asn Ile Tyr His Pro Met Gly Glu
  40                  45                  50                  55

 atc tat gag tgg atg aga gag atc agt gag aag tac aag gaa gtg gtg      306
 Ile Tyr Glu Trp Met Arg Glu Ile Ser Glu Lys Tyr Lys Glu Val Val
                  60                  65                  70

 aca cag cat ttc cta gga gtg acc tat gag acc cac ccc ata tat tat      354
 Thr Gln His Phe Leu Gly Val Thr Tyr Glu Thr His Pro Ile Tyr Tyr
              75                  80                  85

 ctg aag atc agc caa cca tct ggt aat ccc aag aaa atc att tgg atg      402
 Leu Lys Ile Ser Gln Pro Ser Gly Asn Pro Lys Lys Ile Ile Trp Met
          90                  95                 100

 gac tgt gga att cac gcc aga gaa tgg att gct cct gct ttt tgc caa      450
 Asp Cys Gly Ile His Ala Arg Glu Trp Ile Ala Pro Ala Phe Cys Gln
     105                 110                 115

 tgg ttc gtc aaa gaa att cta caa aac cat aaa gac aac tca agg ata      498
 Trp Phe Val Lys Glu Ile Leu Gln Asn His Lys Asp Asn Ser Arg Ile
 120                 125                 130                 135

 cgc aag ctc ctt agg aac ctg gac ttc tat gtc ctt cca gtt ctt aac      546
 Arg Lys Leu Leu Arg Asn Leu Asp Phe Tyr Val Leu Pro Val Leu Asn
                 140                 145                 150

 ata gat ggt tat atc tac act tgg aca act gat cgt ctt tgg agg aaa      594
 Ile Asp Gly Tyr Ile Tyr Thr Trp Thr Thr Asp Arg Leu Trp Arg Lys
             155                 160                 165

 tcc cgt tca ccc cat aat aat ggc aca tgt ttt ggg acg gat ctc aat      642
 Ser Arg Ser Pro His Asn Asn Gly Thr Cys Phe Gly Thr Asp Leu Asn
         170                 175                 180

 cga aat ttc aat gct tct tgg tgt agt att ggt gcc tct aga aac tgc      690
 Arg Asn Phe Asn Ala Ser Trp Cys Ser Ile Gly Ala Ser Arg Asn Cys
     185                 190                 195

 caa gat caa aca ttc tgt ggg aca ggg cca gtg tct gaa cca gag act      738
 Gln Asp Gln Thr Phe Cys Gly Thr Gly Pro Val Ser Glu Pro Glu Thr
 200                 205                 210                 215

 aaa gct gtt gcc agc ttc ata gag agc aag aag gat gat att ttg tgc      786
 Lys Ala Val Ala Ser Phe Ile Glu Ser Lys Lys Asp Asp Ile Leu Cys
                 220                 225                 230

 ttc ctg acc atg cac tct tat ggg cag tta att ctc aca cct tac ggc      834
 Phe Leu Thr Met His Ser Tyr Gly Gln Leu Ile Leu Thr Pro Tyr Gly
             235                 240                 245

 tac acc aaa aat aaa tca agt aac cac cca gaa atg att caa gtt gga      882
 Tyr Thr Lys Asn Lys Ser Ser Asn His Pro Glu Met Ile Gln Val Gly
         250                 255                 260

 cag aag gca gca aat gca ttg aaa gca aag tat gga acc aat tat aga      930
 Gln Lys Ala Ala Asn Ala Leu Lys Ala Lys Tyr Gly Thr Asn Tyr Arg
     265                 270                 275

 gtt gga tcg agt gca gat att tta tat gcc tca tca ggg tct tca aga      978
 Val Gly Ser Ser Ala Asp Ile Leu Tyr Ala Ser Ser Gly Ser Ser Arg
 280                 285                 290                 295

 gat tgg gcc cga gac att ggg att ccc ttc tca tat acg ttt gag ctg     1026
 Asp Trp Ala Arg Asp Ile Gly Ile Pro Phe Ser Tyr Thr Phe Glu Leu
                 300                 305                 310

 agg gac agt gga aca tat ggg ttt gtt ctg cca gaa gct cag atc cag     1074
 Arg Asp Ser Gly Thr Tyr Gly Phe Val Leu Pro Glu Ala Gln Ile Gln
             315                 320                 325

 ccc acc tgt gag gag acc atg gag gct gtg ctg tca gtc ctg gat gat     1122
 Pro Thr Cys Glu Glu Thr Met Glu Ala Val Leu Ser Val Leu Asp Asp
         330                 335                 340

 gtg tat gcg aaa cac tgg cac tcg gac agt gct gga agg gtg aca tct     1170
 Val Tyr Ala Lys His Trp His Ser Asp Ser Ala Gly Arg Val Thr Ser
     345                 350                 355

 gcc act atg ctg ctg ggc ctg ctg gtg tcc tgc atg tct ctt ctc taa     1218
 Ala Thr Met Leu Leu Gly Leu Leu Val Ser Cys Met Ser Leu Leu 
 360                 365                 370

 gtgcattctg cccaggcctg ctcaacccca gtggcatgag tgtggctgga ggaacggtgt   1278

 gttatggttg taaagaaacc aaataattta actaaaaata cttcctattt caaaaaaaaa   1338

 aaaa                                                                1342




      <210> 301
      <211> 1327
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(1203)

      <400> 301
 acttgatgca ttcattctca aggacacttg atccactgcc agagaggccc agaattttct     60

 aacttactgt gtggcaga  atg aag cct ctg ctt gaa acc ctt tat ctt ttg     111
                      Met Lys Pro Leu Leu Glu Thr Leu Tyr Leu Leu
                        1               5                  10

 ggg atg ctg gtt cct gga ggg ctg gga tat gat aga tcc tta gcc caa      159
 Gly Met Leu Val Pro Gly Gly Leu Gly Tyr Asp Arg Ser Leu Ala Gln
              15                  20                  25

 cac aga caa gag att gtg gac aag tca gtg agt cca tgg agc ctg gag      207
 His Arg Gln Glu Ile Val Asp Lys Ser Val Ser Pro Trp Ser Leu Glu
          30                  35                  40

 acg tat tcc tat aac ata tac cac ccc atg gga gag atc tat gag tgg      255
 Thr Tyr Ser Tyr Asn Ile Tyr His Pro Met Gly Glu Ile Tyr Glu Trp
      45                  50                  55

 atg aga gag atc agt gag aag tac aag gaa gtg gtg aca cag cat ttc      303
 Met Arg Glu Ile Ser Glu Lys Tyr Lys Glu Val Val Thr Gln His Phe
  60                  65                  70                  75

 cta gga gtg acc tat gag acc cac ccc ata tat tat ctg aag atc agc      351
 Leu Gly Val Thr Tyr Glu Thr His Pro Ile Tyr Tyr Leu Lys Ile Ser
                  80                  85                  90

 caa cca tct ggt aat ccc aag aaa atc att tgg atg gac tgt gga att      399
 Gln Pro Ser Gly Asn Pro Lys Lys Ile Ile Trp Met Asp Cys Gly Ile
              95                 100                 105

 cac gcc aga gaa tgg att gct cct gct ttt tgc caa tgg ttc gtc aaa      447
 His Ala Arg Glu Trp Ile Ala Pro Ala Phe Cys Gln Trp Phe Val Lys
         110                 115                 120

 gaa att cta caa aac cat aaa gac aac tca agg ata cgc aag ctc ctt      495
 Glu Ile Leu Gln Asn His Lys Asp Asn Ser Arg Ile Arg Lys Leu Leu
     125                 130                 135

 agg aac ctg gac ttc tat gtc ctt cca gtt ctt aac ata gat ggt tat      543
 Arg Asn Leu Asp Phe Tyr Val Leu Pro Val Leu Asn Ile Asp Gly Tyr
 140                 145                 150                 155

 atc tac act tgg aca act gat cgt ctt tgg agg aaa tcc cgt tca ccc      591
 Ile Tyr Thr Trp Thr Thr Asp Arg Leu Trp Arg Lys Ser Arg Ser Pro
                 160                 165                 170

 cat aat aat ggc aca tgt ttt ggg acg gat ctc aat cga aat ttc aat      639
 His Asn Asn Gly Thr Cys Phe Gly Thr Asp Leu Asn Arg Asn Phe Asn
             175                 180                 185

 gct tct tgg tgt agt att ggt gcc tct aga aac tgc caa gat caa aca      687
 Ala Ser Trp Cys Ser Ile Gly Ala Ser Arg Asn Cys Gln Asp Gln Thr
         190                 195                 200

 ttc tgt ggg aca ggg cca gtg tct gaa cca gag act aaa gct gtt gcc      735
 Phe Cys Gly Thr Gly Pro Val Ser Glu Pro Glu Thr Lys Ala Val Ala
     205                 210                 215

 agc ttc ata gag agc aag aag gat gat att ttg tgc ttc ctg acc atg      783
 Ser Phe Ile Glu Ser Lys Lys Asp Asp Ile Leu Cys Phe Leu Thr Met
 220                 225                 230                 235

 cac tct tat ggg cag tta att ctc aca cct tac ggc tac acc aaa aat      831
 His Ser Tyr Gly Gln Leu Ile Leu Thr Pro Tyr Gly Tyr Thr Lys Asn
                 240                 245                 250

 aaa tca agt aac cac cca gaa atg att caa gtt gga cag aag gca gca      879
 Lys Ser Ser Asn His Pro Glu Met Ile Gln Val Gly Gln Lys Ala Ala
             255                 260                 265

 aat gca ttg aaa gca aag tat gga acc aat tat aga gtt gga tcg agt      927
 Asn Ala Leu Lys Ala Lys Tyr Gly Thr Asn Tyr Arg Val Gly Ser Ser
         270                 275                 280

 gca gat att tta tat gcc tca tca ggg tct tca aga gat tgg gcc cga      975
 Ala Asp Ile Leu Tyr Ala Ser Ser Gly Ser Ser Arg Asp Trp Ala Arg
     285                 290                 295

 gac att ggg att ccc ttc tca tat acg ttt gag ctg agg gac agt gga     1023
 Asp Ile Gly Ile Pro Phe Ser Tyr Thr Phe Glu Leu Arg Asp Ser Gly
 300                 305                 310                 315

 aca tat ggg ttt gtt ctg cca gaa gct cag atc cag ccc acc tgt gag     1071
 Thr Tyr Gly Phe Val Leu Pro Glu Ala Gln Ile Gln Pro Thr Cys Glu
                 320                 325                 330

 gag acc atg gag gct gtg ctg tca gtc ctg gat gat gtg tat gcg aaa     1119
 Glu Thr Met Glu Ala Val Leu Ser Val Leu Asp Asp Val Tyr Ala Lys
             335                 340                 345

 cac tgg cac tcg gac agt gct gga agg gtg aca tct gcc act atg ctg     1167
 His Trp His Ser Asp Ser Ala Gly Arg Val Thr Ser Ala Thr Met Leu
         350                 355                 360

 ctg ggc ctg ctg gtg tcc tgc atg tct ctt ctc taa gtgc attctgccca     1217
 Leu Gly Leu Leu Val Ser Cys Met Ser Leu Leu 
     365                 370

 ggcctgctca accccagtgg catgagtgtg gctggaggaa cggtgtgtta tggttgtaaa   1277

 gaaaccaaat aatttaacta aaaatacttc ctatttcaaa aaaaaaaaaa              1327




      <210> 302
      <211> 1027
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(563)

      <220>
      <221> misc_feature
      <222> (1)...(1027)
      <223> n = a,t,c or g

      <400> 302
 gggggatcga gaccattgnn ntttgtagtc actatcagtg cggtggaatt cccggcaag      59                                                                 
 atg gcg gcg gct ggg gct ggc cgt ctg agg cgg gtg gca tcg gct ctg      107
 Met Ala Ala Ala Gly Ala Gly Arg Leu Arg Arg Val Ala Ser Ala Leu
   1               5                  10                  15

 ctg ctg cgg agc ccc cgc ctg ccc gcc cgg gag ctg tcg gcc ccg gcc      155
 Leu Leu Arg Ser Pro Arg Leu Pro Ala Arg Glu Leu Ser Ala Pro Ala
              20                  25                  30

 cga ctc tat cac aag aag gtt gtt gat cat tat gaa aat cct aga aac      203
 Arg Leu Tyr His Lys Lys Val Val Asp His Tyr Glu Asn Pro Arg Asn
          35                  40                  45

 gtg ggg tcc ctt gac aag aca tct aaa aat gtt gga act gga ctg gtg      251
 Val Gly Ser Leu Asp Lys Thr Ser Lys Asn Val Gly Thr Gly Leu Val
      50                  55                  60

 ggg gct cca gca tgt ggt gac gta atg aaa tta cag att caa gtg gat      299
 Gly Ala Pro Ala Cys Gly Asp Val Met Lys Leu Gln Ile Gln Val Asp
  65                  70                  75                  80

 gaa aag ggg aag att gtg gat gct agg ttt aaa aca ttt ggc tgt ggt      347
 Glu Lys Gly Lys Ile Val Asp Ala Arg Phe Lys Thr Phe Gly Cys Gly
                  85                  90                  95

 tcc gca att gcc tcc agc tca tta gcc act gaa tgg gtg aaa gga aag      395
 Ser Ala Ile Ala Ser Ser Ser Leu Ala Thr Glu Trp Val Lys Gly Lys
             100                 105                 110

 acg gtg gag gaa gcc ttg act atc aaa aac aca gat atc gcc aag gag      443
 Thr Val Glu Glu Ala Leu Thr Ile Lys Asn Thr Asp Ile Ala Lys Glu
         115                 120                 125

 ctc tgc ctt cct ccc gtg aaa ctg cac tgc tcc atg ctg gct gaa gat      491
 Leu Cys Leu Pro Pro Val Lys Leu His Cys Ser Met Leu Ala Glu Asp
     130                 135                 140

 gca atc aag gcc gcc ctg gct gat tac aaa ttg aaa caa gaa ccc aaa      539
 Ala Ile Lys Ala Ala Leu Ala Asp Tyr Lys Leu Lys Gln Glu Pro Lys
 145                 150                 155                 160

 aaa gga gag gca gag aag aaa tga gccctccctc ggcgaagcct ccagcaggcc     593
 Lys Gly Glu Ala Glu Lys Lys 
                 165

 acaccagctg tttcccacct gctgtgcagt caccttagat gttcagaagc cgcttcctct    653

 ccactgaaga gctatgagat acgcacaata cttgctgttc acgttatgac tctcatgcaa    713

 gcaaaataca cagtttcatt gttctgaatc ctgtggtttc tttcagccca cttttatcgc    773

 cttaacctag ttaatgtata ttttgaattg tgtgtatgac ctcagaactg aaattgataa    833

 tgaagttgca agttttgata gcccgtgaag tgcataagta tctaatttta cctgaattga    893

 tttgggggga aattaccagt agaatgcctt ggtctgaata tttgatagaa ccaattgttg    953

 tacataaaac agatctgcgc atatatatat atgtataaaa aataataaaa taatggaaga   1013

 tgaaaaaaaa aaaa                                                     1027




      <210> 303
      <211> 1534
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (403)..(1272)

      <400> 303
 aatttgtaaa aaatttttgt aaaaagtttg acataccatt aatatagggg aataataatg     60

 tggtcagggt aactaagcac aatagcatca ccagaatatg tgtatctgct gttaagcaac    120

 atcatcaaca aataaggtta ggctttcagt ccccacctat gatgttattt tttgattaaa    180

 aggtttctag actttttgtt tgtttgtttg ttttattaag gccggaagaa acatcagaat    240

 cgattgaggg accaggaaat ggggcctcta gggaagagaa ggcattctgc tagatggctt    300

 ttaaaaatat ttccgccaga gtcacttgtc tcattaacaa cagtttttgt cttagaagtc    360

 tctctgtgat tttataaact agcatgattt tgttatgaat gc   atg ctg ctc tgg     414
                                                  Met Leu Leu Trp
                                                    1

 ttc tct aat aag ccc aac atg cat ttg cat cat gtc ggc aat aag cac      462
 Phe Ser Asn Lys Pro Asn Met His Leu His His Val Gly Asn Lys His
   5                  10                  15                  20

 ttt ttt tgc tgt gtt aac aat gtc atc ttc att gtt gtg tgc ctg tgt      510
 Phe Phe Cys Cys Val Asn Asn Val Ile Phe Ile Val Val Cys Leu Cys
                  25                  30                  35

 ttt gac tgt gac ctg tca cat gag gtt ggg tgt gga att ttc cac ttg      558
 Phe Asp Cys Asp Leu Ser His Glu Val Gly Cys Gly Ile Phe His Leu
              40                  45                  50

 tgg cat cgt gtt gga gct caa aaa gtt ttg gat ttt gga cca ttt cgg      606
 Trp His Arg Val Gly Ala Gln Lys Val Leu Asp Phe Gly Pro Phe Arg
          55                  60                  65

 att tcg gat ttt tgg att agg aat tct caa cct gtg cta tca gcc agg      654
 Ile Ser Asp Phe Trp Ile Arg Asn Ser Gln Pro Val Leu Ser Ala Arg
      70                  75                  80

 agg ctg gcg cgg cga gcg ctg ttc ggg gct gga ggg ggt aag gcc ggc      702
 Arg Leu Ala Arg Arg Ala Leu Phe Gly Ala Gly Gly Gly Lys Ala Gly
  85                  90                  95                 100

 aag ggc ggc ctg acc ctc cag gag gcc atc cag cgg ctg cgg gac acg      750
 Lys Gly Gly Leu Thr Leu Gln Glu Ala Ile Gln Arg Leu Arg Asp Thr
                 105                 110                 115

 gag gag atg tta agc aag aaa cag gag ttc ctg gag aag aaa atc gag      798
 Glu Glu Met Leu Ser Lys Lys Gln Glu Phe Leu Glu Lys Lys Ile Glu
             120                 125                 130

 cag agg cac ggc acc aaa aac aag ccc gcg gcc ctc cag gca ctg aag      846
 Gln Arg His Gly Thr Lys Asn Lys Pro Ala Ala Leu Gln Ala Leu Lys
         135                 140                 145

 cgt aag aag agg tat gag aag cag ctg gcg cag atc gac ggt aca tta      894
 Arg Lys Lys Arg Tyr Glu Lys Gln Leu Ala Gln Ile Asp Gly Thr Leu
     150                 155                 160

 tca acc atc gag ttc cag cag cag gcc ctg gag aat gcc aac acc aat      942
 Ser Thr Ile Glu Phe Gln Gln Gln Ala Leu Glu Asn Ala Asn Thr Asn
 165                 170                 175                 180

 acc gag gtg ctc aag aac atg ggc tct gca gcc aag gcc aag aag gcg      990
 Thr Glu Val Leu Lys Asn Met Gly Ser Ala Ala Lys Ala Lys Lys Ala
                 185                 190                 195

 gcc cac gac aac atg gac atc gat aaa gtt gat gag tta atg cag gac     1038
 Ala His Asp Asn Met Asp Ile Asp Lys Val Asp Glu Leu Met Gln Asp
             200                 205                 210

 att gct gac cag caa gaa ctt ggg gag gag att tca aca gca att tcg     1086
 Ile Ala Asp Gln Gln Glu Leu Gly Glu Glu Ile Ser Thr Ala Ile Ser
         215                 220                 225

 aaa cct gta ggg ttt gga gaa aag tct gac gag gat gag ctc atg gcg     1134
 Lys Pro Val Gly Phe Gly Glu Lys Ser Asp Glu Asp Glu Leu Met Ala
     230                 235                 240

 gaa tta gaa gaa cta gaa cag gag gaa cca gac aag aat ttg ctg gaa     1182
 Glu Leu Glu Glu Leu Glu Gln Glu Glu Pro Asp Lys Asn Leu Leu Glu
 245                 250                 255                 260

 gtc agt ggc ccc gaa aca gtc cct cta cca aat gtt ccc tct ata gcc     1230
 Val Ser Gly Pro Glu Thr Val Pro Leu Pro Asn Val Pro Ser Ile Ala
                 265                 270                 275

 cta cca tca aaa cct gcc aag aag agg aag acg acg aca tga aggattt     1279
 Leu Pro Ser Lys Pro Ala Lys Lys Arg Lys Thr Thr Thr 
             280                 285

 ggagaactgg gctgggtcca gcgcgggcag gatggatgtg gtgcaggcag gttccatcgc   1339

 tctcgactct cactccaaag cagtagggcc gcattgctgc tcgctctctg catagcatgg   1399

 tctgcaccta gtgggatggg tgggggcggg tagagggggg ttgcggggca cgggggctgt   1459

 gggggagaag tgcctgctgt ttataatgtt gaatttctgt aaaataaact gtgtttgcaa   1519

 atccaaaaaa aaaaa                                                    1534




      <210> 304
      <211> 571
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(489)

      <400> 304
  atg gag agg ctc gtc cta acc ctg tgc acc ctc ccg ctg gct gtg gcg      48
  Met Glu Arg Leu Val Leu Thr Leu Cys Thr Leu Pro Leu Ala Val Ala
    1               5                  10                  15

 tct gct ggc tgc gcc acg acg cca gct cgc aac ctg agc tgc tac cag       96
 Ser Ala Gly Cys Ala Thr Thr Pro Ala Arg Asn Leu Ser Cys Tyr Gln
              20                  25                  30

 tgc ttc aag gtc agc agc tgg acg gag tgc ccg ccc acc tgg tgc agc      144
 Cys Phe Lys Val Ser Ser Trp Thr Glu Cys Pro Pro Thr Trp Cys Ser
          35                  40                  45

 ccg ctg gac caa gtc tgc atc tcc aac gag gtg gtc gtc tct ttt aaa      192
 Pro Leu Asp Gln Val Cys Ile Ser Asn Glu Val Val Val Ser Phe Lys
      50                  55                  60

 tgg agt gta cgc gtc ctg ctc agc aaa cgc tgt gct ccc aga tgt ccc      240
 Trp Ser Val Arg Val Leu Leu Ser Lys Arg Cys Ala Pro Arg Cys Pro
  65                  70                  75                  80

 aac gac aac atg aag ttc gaa tgg tcg ccg gcc ccc atg gtg caa ggc      288
 Asn Asp Asn Met Lys Phe Glu Trp Ser Pro Ala Pro Met Val Gln Gly
                  85                  90                  95

 gtg atc acc agg cgc tgc tgt tcc tgg gct ctc tgc aac agg gca ctg      336
 Val Ile Thr Arg Arg Cys Cys Ser Trp Ala Leu Cys Asn Arg Ala Leu
             100                 105                 110

 acc cca cag gag ggg cgc tgg gcc ctg cga ggg ggg ctc ctg ctc cag      384
 Thr Pro Gln Glu Gly Arg Trp Ala Leu Arg Gly Gly Leu Leu Leu Gln
         115                 120                 125

 gac cct tcg agg ggc aga aga acc tgg gtg cgg cca cag ctg ggg ctc      432
 Asp Pro Ser Arg Gly Arg Arg Thr Trp Val Arg Pro Gln Leu Gly Leu
     130                 135                 140

 cca ctc tgc ctt ccc att tcc agc ccc ctc tgc cca agg gaa acc cag      480
 Pro Leu Cys Leu Pro Ile Ser Ser Pro Leu Cys Pro Arg Glu Thr Gln
 145                 150                 155                 160

 gaa gga taa cactgtg ggtgccccca cctgtgcatt gggaccacga ccttcaccct      536
 Glu Gly 


 cttggagaca ataaactctc atgcccccaa aaaaa                               571




      <210> 305
      <211> 1846
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (120)..(1121)

      <400> 305
 gaccgtcccg gaattcccgg gtcgacccac gcgtccggga agataaggcg gcgcgggaag     60

 aggacacagg gtgggctgga gctcaaatct aactggactc tcgctcctgc tggctggac     119                                                                 
 atg gag gat ttg gag gaa gat gta agg ttt att gtg gat gag acc ttg      167
 Met Glu Asp Leu Glu Glu Asp Val Arg Phe Ile Val Asp Glu Thr Leu
   1               5                  10                  15

 gac ttt ggg ggg ctg tca cca tct gac agc cgt gag gag gaa gac ata      215
 Asp Phe Gly Gly Leu Ser Pro Ser Asp Ser Arg Glu Glu Glu Asp Ile
              20                  25                  30

 aca gtg ttg gtg act cca gag aaa cca ctt cga cgg tgc ctc tcc cac      263
 Thr Val Leu Val Thr Pro Glu Lys Pro Leu Arg Arg Cys Leu Ser His
          35                  40                  45

 cga agt gac cca aat gca gtg gca cct gcc ccc cag ggt gtg agg ctc      311
 Arg Ser Asp Pro Asn Ala Val Ala Pro Ala Pro Gln Gly Val Arg Leu
      50                  55                  60

 agc cta tgc ccc ctc agt cca gag aag ctg gag gag atc ctc gat gag      359
 Ser Leu Cys Pro Leu Ser Pro Glu Lys Leu Glu Glu Ile Leu Asp Glu
  65                  70                  75                  80

 gcc aac cgg ctg gcc gct cag ctg gag cag tgt gcc ctg cag gat cgg      407
 Ala Asn Arg Leu Ala Ala Gln Leu Glu Gln Cys Ala Leu Gln Asp Arg
                  85                  90                  95

 gag agc gca ggc gag ggc ctg ggg cct cgc cga gtg aag ccc agt cct      455
 Glu Ser Ala Gly Glu Gly Leu Gly Pro Arg Arg Val Lys Pro Ser Pro
             100                 105                 110

 cgg cgg gag acc ttt gtg ctg gag gat agt cct gtc cga gac ctg ctg      503
 Arg Arg Glu Thr Phe Val Leu Glu Asp Ser Pro Val Arg Asp Leu Leu
         115                 120                 125

 ccc act gtg aac tct ttg acg cgg agc acc ccc tcc cca agc agc ctg      551
 Pro Thr Val Asn Ser Leu Thr Arg Ser Thr Pro Ser Pro Ser Ser Leu
     130                 135                 140

 acg cct cga ctc cgg agt aat gat agg aag ggg tca gtc agg gct ctc      599
 Thr Pro Arg Leu Arg Ser Asn Asp Arg Lys Gly Ser Val Arg Ala Leu
 145                 150                 155                 160

 cgg gct aca tct gga aag agg ccc tcc aac atg aag agg gag tca ccc      647
 Arg Ala Thr Ser Gly Lys Arg Pro Ser Asn Met Lys Arg Glu Ser Pro
                 165                 170                 175

 act tgc aat ctg ttc cct gca tcc aaa agc cca gca tct tct cct ctt      695
 Thr Cys Asn Leu Phe Pro Ala Ser Lys Ser Pro Ala Ser Ser Pro Leu
             180                 185                 190

 acc cga tcg act ccc cca gtc cgg ggg aga gcc ggg ccc agt ggg aga      743
 Thr Arg Ser Thr Pro Pro Val Arg Gly Arg Ala Gly Pro Ser Gly Arg
         195                 200                 205

 gca gca gcc agc cca ccc acc ccc atc aga tcc gtc ctg gcc cca cag      791
 Ala Ala Ala Ser Pro Pro Thr Pro Ile Arg Ser Val Leu Ala Pro Gln
     210                 215                 220

 cct tct acc agc aac tct caa cgc ctg ccc cgg ccg cag gga gca gct      839
 Pro Ser Thr Ser Asn Ser Gln Arg Leu Pro Arg Pro Gln Gly Ala Ala
 225                 230                 235                 240

 gct aaa tct tcc agt caa ctg ccc att ccc tcg gcc atc ccc agg cct      887
 Ala Lys Ser Ser Ser Gln Leu Pro Ile Pro Ser Ala Ile Pro Arg Pro
                 245                 250                 255

 gcc agc cga atg cca ctc acc agc cgg agt gtg cca cct ggc aga ggt      935
 Ala Ser Arg Met Pro Leu Thr Ser Arg Ser Val Pro Pro Gly Arg Gly
             260                 265                 270

 gcc cta cct ccg gat tct ctg tca act cga aaa ggg ctt cca aga cca      983
 Ala Leu Pro Pro Asp Ser Leu Ser Thr Arg Lys Gly Leu Pro Arg Pro
         275                 280                 285

 agc act gca gga cac aga gtg cgg gaa agt gga cac aag gtt cct gtt     1031
 Ser Thr Ala Gly His Arg Val Arg Glu Ser Gly His Lys Val Pro Val
     290                 295                 300

 tcc cag cga cta aat ctt cct gtc atg ggt gcc act cgc agc aat ctg     1079
 Ser Gln Arg Leu Asn Leu Pro Val Met Gly Ala Thr Arg Ser Asn Leu
 305                 310                 315                 320

 cag ccc ccc agg aaa gtg gca gtc cca gga cct acc agg taa agagatc     1128
 Gln Pro Pro Arg Lys Val Ala Val Pro Gly Pro Thr Arg 
                 325                 330

 aggacagcaa gcaagacttc agtagcaaac cactacagtc agtacctgga ctcgcctcta   1188

 cccagcagac cctgactcca gcagattctg gcccagggac gggaggaaga gatgccacca   1248

 gggctggtct cccaggagta gagaccatgg gaaatggggt ggattaggat tgagctggag   1308

 aagacttaaa ctctctgggt tgaaagaaga ttaggggaaa agaggtcacc ttccagcagt   1368

 gaaatgaaca aatagaaggt gagaagtaca ggcaagtggt ttgtctttat ccacccccac   1428

 tgttgtggtc agccccagag aattttatct tcttccttgg cattggttca ctggacattt   1488

 ccatgtgagc ggcctccgta gctaacctcc ctgccctctg aggagccatc ttcctgaatc   1548

 gcattctcta ctggactctg gcctgcttgg agaggtggca gcaggcacct ggtcttcaga   1608

 aattgtttcc tgtgaattct gtgactccta ataggccagt ttgtgataag cttactctat   1668

 gagtcttcat ttttctaaaa taaagtgaat gtatttttat attctctgta tatctggaag   1728

 ttgatcctgc tcctatttct ttcttttttt ttagacagaa tcttgctctg tcacccaaga   1788

 tcgcgccact gcattccagc ctggtggcag agtgagactc catctcaaaa aaaaaaaa     1846




      <210> 306
      <211> 1039
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(966)

      <400> 306
 attgtaatct gtacgcctgc aggtaccggt ccggaattcc cgggtcgacc cacgcgtccg     60

 ggcagcttgg ag    atg tcg tcg gat ggg gaa ccc ctg agc cgc atg gac     108
                  Met Ser Ser Asp Gly Glu Pro Leu Ser Arg Met Asp
                    1               5                  10

 tcg gag gac agc ata agc agt act ata atg gat gta gac agc aca att      156
 Ser Glu Asp Ser Ile Ser Ser Thr Ile Met Asp Val Asp Ser Thr Ile
          15                  20                  25

 tcc agt ggg cgt tca act cca gca atg atg aat gga caa gga agc act      204
 Ser Ser Gly Arg Ser Thr Pro Ala Met Met Asn Gly Gln Gly Ser Thr
      30                  35                  40

 act tct tca agc aaa aat att gcc tat aat tgt tgt tgg gac cag tgc      252
 Thr Ser Ser Ser Lys Asn Ile Ala Tyr Asn Cys Cys Trp Asp Gln Cys
  45                  50                  55                  60

 cag gct tgc ttc aac tct agc cca gat ctg gca gat cac atc cgt tcc      300
 Gln Ala Cys Phe Asn Ser Ser Pro Asp Leu Ala Asp His Ile Arg Ser
                  65                  70                  75

 ata cat gta gat ggt cag cga gga ggg gta ttt gtt tgc tta tgg aaa      348
 Ile His Val Asp Gly Gln Arg Gly Gly Val Phe Val Cys Leu Trp Lys
              80                  85                  90

 ggt tgt aaa gta tat aac act cca tct acc agt caa agt tgg tta caa      396
 Gly Cys Lys Val Tyr Asn Thr Pro Ser Thr Ser Gln Ser Trp Leu Gln
          95                 100                 105

 agg cat atg ctg aca cac agt gga gac aaa cct ttc aag tgt gtt gtt      444
 Arg His Met Leu Thr His Ser Gly Asp Lys Pro Phe Lys Cys Val Val
     110                 115                 120

 ggt ggc tgc aat gcc agc ttt gct tct cag gga ggg cta gct cgt cat      492
 Gly Gly Cys Asn Ala Ser Phe Ala Ser Gln Gly Gly Leu Ala Arg His
 125                 130                 135                 140

 gta ccc aca cac ttc agt cag cag aac tcc tca aaa gtt tct agc cag      540
 Val Pro Thr His Phe Ser Gln Gln Asn Ser Ser Lys Val Ser Ser Gln
                 145                 150                 155

 cca aag gcc aaa gaa gaa tct cct tct aaa gct gga atg aac aaa agg      588
 Pro Lys Ala Lys Glu Glu Ser Pro Ser Lys Ala Gly Met Asn Lys Arg
             160                 165                 170

 agg aaa tta aag aac aaa aga cga cgc tca tta cca cgg cca cat gat      636
 Arg Lys Leu Lys Asn Lys Arg Arg Arg Ser Leu Pro Arg Pro His Asp
         175                 180                 185

 ttc ttc gat gca caa aca ctg gat gcg ata aga cat cga gcc ata tgc      684
 Phe Phe Asp Ala Gln Thr Leu Asp Ala Ile Arg His Arg Ala Ile Cys
     190                 195                 200

 ttt aac ctc tca gct cat ata gaa agt tta ggg aag gga cac agt gtt      732
 Phe Asn Leu Ser Ala His Ile Glu Ser Leu Gly Lys Gly His Ser Val
 205                 210                 215                 220

 gtt ttt cat agt act gta ata gct aag aga aaa gaa gat tct ggg aag      780
 Val Phe His Ser Thr Val Ile Ala Lys Arg Lys Glu Asp Ser Gly Lys
                 225                 230                 235

 atc aaa ctt ttg ctt cat tgg atg cct gaa gac att ctg cct gat gtg      828
 Ile Lys Leu Leu Leu His Trp Met Pro Glu Asp Ile Leu Pro Asp Val
             240                 245                 250

 tgg gtg aat gaa agt gaa cga cat cag tta aaa act aaa gta gtt cat      876
 Trp Val Asn Glu Ser Glu Arg His Gln Leu Lys Thr Lys Val Val His
         255                 260                 265

 tta tca aag cta ccc aaa gat act gcc ttg ctt ttg gac cca aac ata      924
 Leu Ser Lys Leu Pro Lys Asp Thr Ala Leu Leu Leu Asp Pro Asn Ile
     270                 275                 280

 tac aga aca atg ccg cag aag agg ttg aag aga aga cac taa ggatcat      973
 Tyr Arg Thr Met Pro Gln Lys Arg Leu Lys Arg Arg His 
 285                 290                 295

 gtgaaagagc tccctacgaa atcgtcgaca gcgaagtcga cccgggagat tccgggcgag   1033

 tgcctg                                                              1039




      <210> 307
      <211> 4671
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (930)..(2606)

      <400> 307
 gcggccgcag acaaagggcg gctcgcgccc gggccgccac gctctcgggc tctgcctcgg     60

 gaaggagact tggtctgaaa gatgccacat tcctgcagcc tctcttggtg cagtggaata    120

 cagtcttggg cgaggtggcg tggatgagct ggtgaaagag gatgctgccc acatccaaag    180

 gctccagagg atcctggcct ggcagctgag ctcccctgca tttggaacct caggcgtaac    240

 ttggtgtaga gctcatgaaa ggtgcttgtg tttctccagc ttttttcacc agtgcttacc    300

 agactggctc aggttttgga atctaaggtg agctggtaga aacaggagag gtagaaagaa    360

 gcccctggat gcctccagaa ttcattgatg ggatccctgc atactgcttg gaacacagaa    420

 agaggctgtg acacagctga gctttggagc atcttaagga gctcagctca gcaaacaact    480

 cttgcatttc agccagaaag agcctcttgt aacaaagtat tcaaagggga gagtttctgc    540

 atcttttact ttgcagtcca ctatggtaga aaacttgaca ttccatagat aatgatactg    600

 ggttttcttt ccaagatgcc agctttaaaa gaaatatgag ccattctaag ctttaagaag    660

 ggttcaggaa acacaggaat tagtagacag ccctcccaat gcaggttaag acgacagcct    720

 gcgcccccaa ctagcacagc tcagcgagca tgaccatatg ccattctcgt ctccagagag    780

 ctggtggcag tgacctcact aggagaaaac acatccctca gccgtgggac ttgacagaat    840

 gaggtgcgcg agggaggccg ctagccgaga cttggccttt cctgactgcc cctgtgttac    900

 ctgggcagct ccagatcact gagcccaca  atg gct gag aag ggt gac tgc atc     953
                                  Met Ala Glu Lys Gly Asp Cys Ile
                                    1               5

 gcc agt gtc tat ggg tat gac ctc ggt ggg cgc ttt gtt gac ttc caa     1001
 Ala Ser Val Tyr Gly Tyr Asp Leu Gly Gly Arg Phe Val Asp Phe Gln
      10                  15                  20

 ccc ctg ggc ttc ggt gtc aat ggt ttg gtg ctg tcg gcc gtg gac agc     1049
 Pro Leu Gly Phe Gly Val Asn Gly Leu Val Leu Ser Ala Val Asp Ser
  25                  30                  35                  40

 cgg gcc tgc cgg aag gtc gct gtg aag aag att gcc ctg agc gat gcc     1097
 Arg Ala Cys Arg Lys Val Ala Val Lys Lys Ile Ala Leu Ser Asp Ala
                  45                  50                  55

 cgc agc atg aag cac gcg ctc cga gag atc aag atc att cgg cgc ctg     1145
 Arg Ser Met Lys His Ala Leu Arg Glu Ile Lys Ile Ile Arg Arg Leu
              60                  65                  70

 gac cac gac aac atc gtc aaa gtg tac gag gtg ctc ggt ccc aag ggc     1193
 Asp His Asp Asn Ile Val Lys Val Tyr Glu Val Leu Gly Pro Lys Gly
          75                  80                  85

 act gac ctg cag ggt gag ctg ttc aag ttc agc gtg gcg tac atc gtc     1241
 Thr Asp Leu Gln Gly Glu Leu Phe Lys Phe Ser Val Ala Tyr Ile Val
      90                  95                 100

 cag gag tac atg gag acc gac ctg gca cgc ctg ctg gag cag ggc acg     1289
 Gln Glu Tyr Met Glu Thr Asp Leu Ala Arg Leu Leu Glu Gln Gly Thr
 105                 110                 115                 120

 ctg gca gaa gag cat gcc aag ctg ttc atg tac cag ctg ctc cgc ggg     1337
 Leu Ala Glu Glu His Ala Lys Leu Phe Met Tyr Gln Leu Leu Arg Gly
                 125                 130                 135

 ctc aag tac atc cac tcc gcc aac gtg ctg cac agg gac ctg aag ccc     1385
 Leu Lys Tyr Ile His Ser Ala Asn Val Leu His Arg Asp Leu Lys Pro
             140                 145                 150

 gcc aac atc ttc atc agc aca gag gac ctc gtg ctc aag att ggg gat     1433
 Ala Asn Ile Phe Ile Ser Thr Glu Asp Leu Val Leu Lys Ile Gly Asp
         155                 160                 165

 ttc ggg ttg gca agg atc gtt gat cag cat tac tcc cac aag ggt tat     1481
 Phe Gly Leu Ala Arg Ile Val Asp Gln His Tyr Ser His Lys Gly Tyr
     170                 175                 180

 ctg tca gaa ggg ttg gta aca aag tgg tac cgt tcc cca cga ctg ctc     1529
 Leu Ser Glu Gly Leu Val Thr Lys Trp Tyr Arg Ser Pro Arg Leu Leu
 185                 190                 195                 200

 ctt tcc ccc aat aac tac acc aaa gcc atc gac atg tgg gcc gcc ggc     1577
 Leu Ser Pro Asn Asn Tyr Thr Lys Ala Ile Asp Met Trp Ala Ala Gly
                 205                 210                 215

 tgc atc ctg gct gag atg ctt acg ggg aga atg ctc ttt gct ggg gcc     1625
 Cys Ile Leu Ala Glu Met Leu Thr Gly Arg Met Leu Phe Ala Gly Ala
             220                 225                 230

 cat gag ctg gag cag atg caa ctc atc ctg gag acc atc cct gta atc     1673
 His Glu Leu Glu Gln Met Gln Leu Ile Leu Glu Thr Ile Pro Val Ile
         235                 240                 245

 cgg gag gaa gac aag gac gag ctg ctc agg gtg atg cct tcc ttt gtc     1721
 Arg Glu Glu Asp Lys Asp Glu Leu Leu Arg Val Met Pro Ser Phe Val
     250                 255                 260

 agc agc acc tgg gag gtg aag agg cct ctg cgc aag ctg ctc cct gaa     1769
 Ser Ser Thr Trp Glu Val Lys Arg Pro Leu Arg Lys Leu Leu Pro Glu
 265                 270                 275                 280

 gtg aac agt gaa gcc atc gac ttt ctg gag aag atc ctg acc ttt aac     1817
 Val Asn Ser Glu Ala Ile Asp Phe Leu Glu Lys Ile Leu Thr Phe Asn
                 285                 290                 295

 ccc atg gat cgc cta aca gct gag atg ggg ctg caa cac ccc tac atg     1865
 Pro Met Asp Arg Leu Thr Ala Glu Met Gly Leu Gln His Pro Tyr Met
             300                 305                 310

 agc cca tac tcg tgc cct gag gac gag ccc acc tca caa cac ccc ttc     1913
 Ser Pro Tyr Ser Cys Pro Glu Asp Glu Pro Thr Ser Gln His Pro Phe
         315                 320                 325

 cgc att gag gat gag atc gac gac atc gtg ctg atg gcc gct aac cag     1961
 Arg Ile Glu Asp Glu Ile Asp Asp Ile Val Leu Met Ala Ala Asn Gln
     330                 335                 340

 agc cag ctg tcc aac tgg gac acg tgc agt tcc agg tac cct gtg agc     2009
 Ser Gln Leu Ser Asn Trp Asp Thr Cys Ser Ser Arg Tyr Pro Val Ser
 345                 350                 355                 360

 ctg tcg tcg gac ctg gag tgg cgg cct gac cgg tgc cag gac gcc agc     2057
 Leu Ser Ser Asp Leu Glu Trp Arg Pro Asp Arg Cys Gln Asp Ala Ser
                 365                 370                 375

 gag gta cag cgc gac ccg cgc gcg ggt tcg gcg cca ctg gct gag aac     2105
 Glu Val Gln Arg Asp Pro Arg Ala Gly Ser Ala Pro Leu Ala Glu Asn
             380                 385                 390

 gtg cag gtg gac ccg cgc aag gac tcg cac agc agc tcc gag cgc ttc     2153
 Val Gln Val Asp Pro Arg Lys Asp Ser His Ser Ser Ser Glu Arg Phe
         395                 400                 405

 cta gag cag tcg cac tcg tcc atg gag cgc gcc ttc gag gcc gac tac     2201
 Leu Glu Gln Ser His Ser Ser Met Glu Arg Ala Phe Glu Ala Asp Tyr
     410                 415                 420

 ggg cgc tcc tgc gac tac aag gtg ggg tcg ccg tcc tac ctg gac aag     2249
 Gly Arg Ser Cys Asp Tyr Lys Val Gly Ser Pro Ser Tyr Leu Asp Lys
 425                 430                 435                 440

 ctg ctg tgg cgc gac aac aag ccg cac cac tac tcg gag ccc aag ctc     2297
 Leu Leu Trp Arg Asp Asn Lys Pro His His Tyr Ser Glu Pro Lys Leu
                 445                 450                 455

 atc ctg gac ctg tcg cac tgg aag cag gcg gcc ggc gcg ccc ccc acg     2345
 Ile Leu Asp Leu Ser His Trp Lys Gln Ala Ala Gly Ala Pro Pro Thr
             460                 465                 470

 gcc acg ggg ctg gcg gac acg ggg gcg cgc gag gac gag ccg gcc agc     2393
 Ala Thr Gly Leu Ala Asp Thr Gly Ala Arg Glu Asp Glu Pro Ala Ser
         475                 480                 485

 ctc ttc ctg gag atc gcg cag tgg gtc aag agc acg cag ggc gcc cag     2441
 Leu Phe Leu Glu Ile Ala Gln Trp Val Lys Ser Thr Gln Gly Ala Gln
     490                 495                 500

 agc acg cca gcc cgc ccg ccg acg acc ccg agc gcc gct tgt ctg cct     2489
 Ser Thr Pro Ala Arg Pro Pro Thr Thr Pro Ser Ala Ala Cys Leu Pro
 505                 510                 515                 520

 cgc ccc ccg ccg ccc ggc ccc ggt gga cgg cgg cgc cag ccc cca gtt     2537
 Arg Pro Pro Pro Pro Gly Pro Gly Gly Arg Arg Arg Gln Pro Pro Val
                 525                 530                 535

 cga cct gga cgt gtt cat ctc ccg cgc cct gaa gct ctg cac caa gcc     2585
 Arg Pro Gly Arg Val His Leu Pro Arg Pro Glu Ala Leu His Gln Ala
             540                 545                 550

 cga gga cct gcc gga caa taa ac tgggcgacct caatggtgcg tgcatccccg     2638
 Arg Gly Pro Ala Gly Gln 
         555

 agcaccctgg cgacctcgtg cagaccgagg ccttctccaa agaaaggtgg tgagggcgga   2698

 ggggccgctc caggccccac agagcaggag acccccagag aaagccgggg ctggcaggag   2758

 gcggccgcct ccgccctctc tgctgccttg gggttggcag aacacgtgaa ggatccgagg   2818

 agcgagagga atgtccattt cttaaactgc cttaataact agcctttaac ctgtgggagc   2878

 gggtttgaac aggaccctgg cttaggggtt gatcactttc ctagcaaagg ggagaccaca   2938

 tgtggtgcac agggaagaaa cggctttaga cagcagtctg cgggccccac ctgggtggca   2998

 ggatgccgag aaatcttgca gaggtagctc cgaaaccatc tggcccaact agcctcaact   3058

 gacagctgag gaaaggcaat taggcccaga gaggcagaga cactcgctta agatcacagg   3118

 cttagtgtga ggacgagctt gaaatcccag tctcctggcc cccaggccag ggtctgtcca   3178

 ccatagaatg tcttcctcta ctggggtcgt tctggctttt tgttagaaac ttggtctgag   3238

 atgtttcttc cctgtccatt accattcgat gttcttttat tcagagcaat gtttcttgta   3298

 ttctgaaact ggaaactgaa ccagtttgtt tctcctagtc accaagcata ctttcctggc   3358

 tccccaagta cttaaatgtt ctcatctgtc gcacccctgt atttgcctca cccctgcatg   3418

 gtcggaaatc ttcgtttcag gtcagaacag cctggggtct gtgggtaaaa tcagcccttc   3478

 tcccaggcct gtgcacacac cccctcagca ctccctatgc actttcctga cacgcaaaga   3538

 cacagccctc tttccccact gggcgtccta ccccagtgag gttgaaggca ccaattccaa   3598

 gaatccctcc aacctccctg ccagcactcc cccttcaccc cacacccggc ccccccacct   3658

 aaccacagcg cctctccaga cctacctcgg gacctaatgt tctctacatg aactgctcat   3718

 ttggaggaca gcagtgaggt cctgccatag agcaaatgtg ttaggagaga aggtttcaca   3778

 tgggacccaa catccttcat caatactttc ctgagtttga tcatccattt agccttgaca   3838

 aacagcagac cctacagaga tgtgttggag agcacgtcgt gaccttgggg gcaaggaatc   3898

 cagaaaggta ggaagatatg aaaagagagg tgtcaacagc aagggctctt aggggtcagg   3958

 caccagcatg gagacctcat gacaaaggaa gggactcaaa gcagcaatgc ccctcatagt   4018

 gtaggctaag gtgagtttgg tgcatgcaaa cctgtgtgct cacccacaga gcatggggta   4078

 atggtgtgta gacacaggcc ctctgcagaa gcgtggggtg gggacactga cagcccctat   4138

 ctggtcccca ggaacattct accatttctg ccactggtgt tcagctcctt ctcttccccc   4198

 aacactccca aagataccca caggaagtcc agccagtttc caggtagagg attccaccag   4258

 ttggtcttgg gctgcgttca ccctcacatc acagcacctt aaatctaatc agcaaactat   4318

 aatttgtacg ttgaaacctg caacacatta gaaacttata tttaaaaaca gaattaatca   4378

 cactgaccaa cttttaaatg gaaaatatgt aaataggaag tgtttgggtt ttgttttttc   4438

 tttaagaaaa agaaatgtac accactcctc atgtgccatt ttgtcctcag agggcggctt   4498

 tacttttttg gtaaaggaac aagctgctgg ccttgaccag gagttcatat ataactgtta   4558

 ttacagagga attgttataa ctactaatgt ttttaaaaaa tttattaaac attattaaac   4618

 ttgatcaggt caggccaaat aaagttttat tggaacacag aaaaaaaaaa aaa          4671




      <210> 308
      <211> 4717
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (452)..(3799)

      <400> 308
 tgtggggaaa aacaattgaa gccgtatttg taagctgtac gcctgcaggt accggtccgg     60

 aattcccggg tcgacccacg cgtccgcaga attctcaaag ctgacggatc ggtggcagaa    120

 tgctgtccag ggtgttcggc agaggaaggg tgacgttgat gggctggtga ggcagtggca    180

 agatttcact acttctgtgg agaacttgtt tcgcttcctc actgacacca gccacctgct    240

 atctgcagtg aagggccagg agcgcttcag cctataccaa accagaagtc tgatccatga    300

 gctgaagaat aaagaaattc attttcaaag gaggcgaact acctgtgccc taaccttgga    360

 agctggagaa aagttactgc tcacaactga cctgaaaact aaagagtctg tgggtaggag    420

 aatcagtcaa cttcaggaca gctggaaaga c   atg gag ccc cag ctg gca gag     472
                                      Met Glu Pro Gln Leu Ala Glu
                                        1               5

 atg att aag cag ttc cag agc act gta gag acc tgg gac cag tgt gaa      520
 Met Ile Lys Gln Phe Gln Ser Thr Val Glu Thr Trp Asp Gln Cys Glu
          10                  15                  20

 aag aaa atc aag gag ttg aaa agc agg ctg caa gtt tta aag gca caa      568
 Lys Lys Ile Lys Glu Leu Lys Ser Arg Leu Gln Val Leu Lys Ala Gln
      25                  30                  35

 agt gaa gat cct ctt cca gag ctt cac gag gac ctc cat aac gaa aaa      616
 Ser Glu Asp Pro Leu Pro Glu Leu His Glu Asp Leu His Asn Glu Lys
  40                  45                  50                  55

 gag ctg att aag gaa cta gaa cag tct ttg gct agc tgg act cag aac      664
 Glu Leu Ile Lys Glu Leu Glu Gln Ser Leu Ala Ser Trp Thr Gln Asn
                  60                  65                  70

 ttg aaa gaa ctt caa act atg aag gcg gac tta acc cgg cac gtt ctc      712
 Leu Lys Glu Leu Gln Thr Met Lys Ala Asp Leu Thr Arg His Val Leu
              75                  80                  85

 gtg gaa gat gtg atg gtt ttg aag gag caa ata gag cat ttg cac aga      760
 Val Glu Asp Val Met Val Leu Lys Glu Gln Ile Glu His Leu His Arg
          90                  95                 100

 caa tgg gag gac ctc tgc tta agg gtg gcc ata cgt aaa cag gag att      808
 Gln Trp Glu Asp Leu Cys Leu Arg Val Ala Ile Arg Lys Gln Glu Ile
     105                 110                 115

 gaa gac aga ctc aat aca tgg gtt gta ttc aat gaa aaa aat aaa gag      856
 Glu Asp Arg Leu Asn Thr Trp Val Val Phe Asn Glu Lys Asn Lys Glu
 120                 125                 130                 135

 ttg tgt gcc tgg ctg gtg cag atg gaa aac aaa gtt cta cag aca gcg      904
 Leu Cys Ala Trp Leu Val Gln Met Glu Asn Lys Val Leu Gln Thr Ala
                 140                 145                 150

 gac att agt att gaa gaa atg att gaa aag tta cag aag gac tgc atg      952
 Asp Ile Ser Ile Glu Glu Met Ile Glu Lys Leu Gln Lys Asp Cys Met
             155                 160                 165

 gaa gaa ata aac ttg ttt agt gaa aac aag tta cag tta aag cag atg     1000
 Glu Glu Ile Asn Leu Phe Ser Glu Asn Lys Leu Gln Leu Lys Gln Met
         170                 175                 180

 ggt gac cag ttg atc aag gcc agc aac aaa tca aga gca gct gag atc     1048
 Gly Asp Gln Leu Ile Lys Ala Ser Asn Lys Ser Arg Ala Ala Glu Ile
     185                 190                 195

 gat gac aag ctc aac aaa att aac gat cgt tgg caa cat ctt ttt gat     1096
 Asp Asp Lys Leu Asn Lys Ile Asn Asp Arg Trp Gln His Leu Phe Asp
 200                 205                 210                 215

 gtc atc gga tca agg gtg aag aag ctg aag gag acc ttt gct ttt att     1144
 Val Ile Gly Ser Arg Val Lys Lys Leu Lys Glu Thr Phe Ala Phe Ile
                 220                 225                 230

 cag cag ttg gac aaa aac atg agc aac ctt cgc acc tgg ttg gct cga     1192
 Gln Gln Leu Asp Lys Asn Met Ser Asn Leu Arg Thr Trp Leu Ala Arg
             235                 240                 245

 att gag tct gag ctt tcc aag cct gtt gtt tat gat gtc tgc gat gat     1240
 Ile Glu Ser Glu Leu Ser Lys Pro Val Val Tyr Asp Val Cys Asp Asp
         250                 255                 260

 caa gag atc cag aag agg ctc gct gag cag cag gat cta cag cga gat     1288
 Gln Glu Ile Gln Lys Arg Leu Ala Glu Gln Gln Asp Leu Gln Arg Asp
     265                 270                 275

 att gaa caa cac agc gca ggg gtg gag tcc gtg ttt aac atc tgt gac     1336
 Ile Glu Gln His Ser Ala Gly Val Glu Ser Val Phe Asn Ile Cys Asp
 280                 285                 290                 295

 gtc cta ctg cac gac tcc gat gcc tgt gca aat gag acc gag tgt gac     1384
 Val Leu Leu His Asp Ser Asp Ala Cys Ala Asn Glu Thr Glu Cys Asp
                 300                 305                 310

 tcg atc cag cag acc acc agg agc ctg gac aga cgc tgg agg aac att     1432
 Ser Ile Gln Gln Thr Thr Arg Ser Leu Asp Arg Arg Trp Arg Asn Ile
             315                 320                 325

 tgt gcc atg tcc atg gag cgg cgc atg aaa atc gag gag acg tgg cgc     1480
 Cys Ala Met Ser Met Glu Arg Arg Met Lys Ile Glu Glu Thr Trp Arg
         330                 335                 340

 ctg tgg cag aag ttt tta gac gac tat tct cgc ttt gag gac tgg ctc     1528
 Leu Trp Gln Lys Phe Leu Asp Asp Tyr Ser Arg Phe Glu Asp Trp Leu
     345                 350                 355

 aag tca gct gag agg acg gca gcc tgc cca aat tcc tca gag gtg ttg     1576
 Lys Ser Ala Glu Arg Thr Ala Ala Cys Pro Asn Ser Ser Glu Val Leu
 360                 365                 370                 375

 tac acg agt gcc aaa gag gaa ctg aag agg ttt gag gcc ttt cag cgg     1624
 Tyr Thr Ser Ala Lys Glu Glu Leu Lys Arg Phe Glu Ala Phe Gln Arg
                 380                 385                 390

 cag att cat gag cgg ctc act cag ctg gag ctc atc aac aag cag tac     1672
 Gln Ile His Glu Arg Leu Thr Gln Leu Glu Leu Ile Asn Lys Gln Tyr
             395                 400                 405

 cgg cgg ctg gcc cgg gag aac cgc aca gac acg gcc agc agg ctg aag     1720
 Arg Arg Leu Ala Arg Glu Asn Arg Thr Asp Thr Ala Ser Arg Leu Lys
         410                 415                 420

 cag atg gtc cac gag ggc aac cag cgc tgg gac aac ctt cag agg cgg     1768
 Gln Met Val His Glu Gly Asn Gln Arg Trp Asp Asn Leu Gln Arg Arg
     425                 430                 435

 gtc aca gcc gtc ctg cgg aga ctc agg cat ttc acc aac cag agg gaa     1816
 Val Thr Ala Val Leu Arg Arg Leu Arg His Phe Thr Asn Gln Arg Glu
 440                 445                 450                 455

 gaa ttt gag ggc acc agg gag agc att ctg gtg tgg ctc aca gag atg     1864
 Glu Phe Glu Gly Thr Arg Glu Ser Ile Leu Val Trp Leu Thr Glu Met
                 460                 465                 470

 gac ctg cag ctg acc aac gtg gag cac ttc tca gag agt gac gcc gat     1912
 Asp Leu Gln Leu Thr Asn Val Glu His Phe Ser Glu Ser Asp Ala Asp
             475                 480                 485

 gac aag atg cgc caa ctg aat ggc ttc caa cag gaa att aca tta aat     1960
 Asp Lys Met Arg Gln Leu Asn Gly Phe Gln Gln Glu Ile Thr Leu Asn
         490                 495                 500

 acc aac aag att gat cag ctc att gtg ttt ggg gag cag ctg att cag     2008
 Thr Asn Lys Ile Asp Gln Leu Ile Val Phe Gly Glu Gln Leu Ile Gln
     505                 510                 515

 aag agc gag ccc ctg gat gct gtg ctg att gag gat gag ctg gag gaa     2056
 Lys Ser Glu Pro Leu Asp Ala Val Leu Ile Glu Asp Glu Leu Glu Glu
 520                 525                 530                 535

 ctc cac cgc tac tgc cag gag gtg ttt gga agg gtc tcc cgg ttc cac     2104
 Leu His Arg Tyr Cys Gln Glu Val Phe Gly Arg Val Ser Arg Phe His
                 540                 545                 550

 cgg cgg ctc acc tcc tgc act ccg ggc ttg gaa gat gaa aag gag gcc     2152
 Arg Arg Leu Thr Ser Cys Thr Pro Gly Leu Glu Asp Glu Lys Glu Ala
             555                 560                 565

 tct gag aat gaa aca gac atg gaa gac ccc aga gaa atc cag act gat     2200
 Ser Glu Asn Glu Thr Asp Met Glu Asp Pro Arg Glu Ile Gln Thr Asp
         570                 575                 580

 tct tgg cgt aaa cgg gga gag agc gag gaa ccg tca tct cct cag tcc     2248
 Ser Trp Arg Lys Arg Gly Glu Ser Glu Glu Pro Ser Ser Pro Gln Ser
     585                 590                 595

 ctg tgt cat cta gtg gcc cca ggg cac gag cgg tct ggc tgc gag acc     2296
 Leu Cys His Leu Val Ala Pro Gly His Glu Arg Ser Gly Cys Glu Thr
 600                 605                 610                 615

 cct gtc agc gtg gac tcc atc ccc ctg gag tgg gac cac aca ggc gac     2344
 Pro Val Ser Val Asp Ser Ile Pro Leu Glu Trp Asp His Thr Gly Asp
                 620                 625                 630

 gtg ggg ggc tcc tcc tct cac gaa gag gac gag gag ggc cca tac tac     2392
 Val Gly Gly Ser Ser Ser His Glu Glu Asp Glu Glu Gly Pro Tyr Tyr
             635                 640                 645

 agc gca ctg tca gat gta gaa atc cct gaa aat cct gag gca tat ctt     2440
 Ser Ala Leu Ser Asp Val Glu Ile Pro Glu Asn Pro Glu Ala Tyr Leu
         650                 655                 660

 aaa atg acc aca aaa act ttg aaa gcg tct tct ggt aaa tcc att tcg     2488
 Lys Met Thr Thr Lys Thr Leu Lys Ala Ser Ser Gly Lys Ser Ile Ser
     665                 670                 675

 gat ggc cac tcg tgg cat gtt ccc gac agc cct tcc tgt ccc gag cat     2536
 Asp Gly His Ser Trp His Val Pro Asp Ser Pro Ser Cys Pro Glu His
 680                 685                 690                 695

 cac tac aag caa atg gaa ggt gac agg aat gtt cca cct gtt ccc cct     2584
 His Tyr Lys Gln Met Glu Gly Asp Arg Asn Val Pro Pro Val Pro Pro
                 700                 705                 710

 gcg tcc agc acc cct tat aaa cca ccc tat gga aag cta cta tta cct     2632
 Ala Ser Ser Thr Pro Tyr Lys Pro Pro Tyr Gly Lys Leu Leu Leu Pro
             715                 720                 725

 cca ggc acg gat ggt ggc aaa gaa ggc ccg cga gtc ctg aat ggc aac     2680
 Pro Gly Thr Asp Gly Gly Lys Glu Gly Pro Arg Val Leu Asn Gly Asn
         730                 735                 740

 cca cag cag gaa gac ggg gga ctg gcc ggt atc aca gag cag cag tca     2728
 Pro Gln Gln Glu Asp Gly Gly Leu Ala Gly Ile Thr Glu Gln Gln Ser
     745                 750                 755

 ggt gcc ttc gac aga tgg gag atg att caa gca cag gag ctt cac aat     2776
 Gly Ala Phe Asp Arg Trp Glu Met Ile Gln Ala Gln Glu Leu His Asn
 760                 765                 770                 775

 aag ctc aaa ata aaa caa aat ttg caa cag ctg aac tct gat atc agc     2824
 Lys Leu Lys Ile Lys Gln Asn Leu Gln Gln Leu Asn Ser Asp Ile Ser
                 780                 785                 790

 gcc atc act act tgg ctg aaa aaa act gaa gca gag ctg gaa atg tta     2872
 Ala Ile Thr Thr Trp Leu Lys Lys Thr Glu Ala Glu Leu Glu Met Leu
             795                 800                 805

 aag atg gca aag cct ccc tct gat atc cag gaa ata gaa ctg aga gtg     2920
 Lys Met Ala Lys Pro Pro Ser Asp Ile Gln Glu Ile Glu Leu Arg Val
         810                 815                 820

 aag aga ctg cag gag ata ctg aaa gcc ttt gac act tac aag gca tta     2968
 Lys Arg Leu Gln Glu Ile Leu Lys Ala Phe Asp Thr Tyr Lys Ala Leu
     825                 830                 835

 gtg gtc tct gtc aac gtg agc agc aag gaa ttt ctg caa acc gag agc     3016
 Val Val Ser Val Asn Val Ser Ser Lys Glu Phe Leu Gln Thr Glu Ser
 840                 845                 850                 855

 ccc gaa tcc aca gag ctc caa agt aga ctc cgc cag ctg agc ctg ctc     3064
 Pro Glu Ser Thr Glu Leu Gln Ser Arg Leu Arg Gln Leu Ser Leu Leu
                 860                 865                 870

 tgg gaa gca gca cag ggc gca gtg gac agc tgg aga ggg ggc tta cga     3112
 Trp Glu Ala Ala Gln Gly Ala Val Asp Ser Trp Arg Gly Gly Leu Arg
             875                 880                 885

 cag tcg ctc atg cag tgc cag gac ttc cac cag ttg agt caa aat ctg     3160
 Gln Ser Leu Met Gln Cys Gln Asp Phe His Gln Leu Ser Gln Asn Leu
         890                 895                 900

 ctg ctg tgg tta gcg agt gcc aag aac cgg agg cag aag gct cat gtc     3208
 Leu Leu Trp Leu Ala Ser Ala Lys Asn Arg Arg Gln Lys Ala His Val
     905                 910                 915

 acc gat cca aag gca gac ccc cgg gct ctc cta gag tgt cgg agg gaa     3256
 Thr Asp Pro Lys Ala Asp Pro Arg Ala Leu Leu Glu Cys Arg Arg Glu
 920                 925                 930                 935

 cta atg caa ctg gaa aag gag ctg gta gaa cgt caa cct caa gtg gac     3304
 Leu Met Gln Leu Glu Lys Glu Leu Val Glu Arg Gln Pro Gln Val Asp
                 940                 945                 950

 atg tta cag gag att tca aac agc ctt ctc att aag gga cat gga gaa     3352
 Met Leu Gln Glu Ile Ser Asn Ser Leu Leu Ile Lys Gly His Gly Glu
             955                 960                 965

 gac tgt att gaa gct gaa gaa aag gtg cat gtt att gag aag aaa ctc     3400
 Asp Cys Ile Glu Ala Glu Glu Lys Val His Val Ile Glu Lys Lys Leu
         970                 975                 980

 aaa cag tta cgg gag caa gtg tcc caa gat tta atg gcc ttg cag gga     3448
 Lys Gln Leu Arg Glu Gln Val Ser Gln Asp Leu Met Ala Leu Gln Gly
     985                 990                 995

 acc cag aac cca gcc tca ccc ctg ccc agc ttc gac gag gta gac tcg     3496
 Thr Gln Asn Pro Ala Ser Pro Leu Pro Ser Phe Asp Glu Val Asp Ser
1000                1005                1010                1015

 ggg gac cag cct cct gca aca tcc gtg cca gct ccc cga gca aag cag     3544
 Gly Asp Gln Pro Pro Ala Thr Ser Val Pro Ala Pro Arg Ala Lys Gln
                1020                1025                1030

 ttc aga gca gtg aga act aca gaa ggc gag gag gag aca gag agc agg     3592
 Phe Arg Ala Val Arg Thr Thr Glu Gly Glu Glu Glu Thr Glu Ser Arg
            1035                1040                1045

 gtc ccc ggc agc aca cgg cca cag cgc tcc ttc ctc tca agg gtg gtc     3640
 Val Pro Gly Ser Thr Arg Pro Gln Arg Ser Phe Leu Ser Arg Val Val
        1050                1055                1060

 cgg gca gcc cta ccc ctg cag ctg ctc ctc ctg ctg ctg ctg ctc ctg     3688
 Arg Ala Ala Leu Pro Leu Gln Leu Leu Leu Leu Leu Leu Leu Leu Leu
    1065                1070                1075

 gcc tgc ctg ctg ccc tcc tcc gaa gaa gac tac agc tgc act cag gcc     3736
 Ala Cys Leu Leu Pro Ser Ser Glu Glu Asp Tyr Ser Cys Thr Gln Ala
1080                1085                1090                1095

 aac aac ttt gcc cgg tcc ttt tac ccc atg ctg agg tac acc aat ggg     3784
 Asn Asn Phe Ala Arg Ser Phe Tyr Pro Met Leu Arg Tyr Thr Asn Gly
                1100                1105                1110

 cca ccc ccc aca tag agggcatagc tggccacagt gctacaccac ctgcctgatt     3839
 Pro Pro Pro Thr 
            1115

 gccaagggtg cccagcacgt ggccccagac caatctgagt gacttagtgt tggcaaggtc   3899

 ccgggacctg tgcagacttc ttctgggctt acacagcacg ggctccctgg agcccagggc   3959

 agctttcaga ttgtgttcct ccccaggagc agggaacctg tgtggcaggt gccccgggta   4019

 ctttggcaga actagttgat tagtttaggg atctctggaa atgtcagttt cctgaagagc   4079

 caagcacttt gtgaattctg gtttgtttgt aaaacagcat tattataatg taggtatggt   4139

 caatgagcag tggtgtccat cacatatatt atagaagcaa gcgagcacat tccaccctag   4199

 aaatggttca gaaactcata ggcaccctta gctgatggaa acaatcaatc atatttaata   4259

 cgcttagaat cagttttact ccaatcagct ggcaattttg agctgccggt tatacaccaa   4319

 aatgttctgt tcagtaccta gctctgctct tttatattgc tttaaatttt taaagaaatt   4379

 atattgcatg gatgtggtta tttgtgcata ttttttaaca atgcccaatc tgtatgaata   4439

 atgtaaactt cgattttttt ttaaaaaaat tagattttag ctggagcttt tgactaatgt   4499

 aaagtaaatg ccaaactacc gacttgatag ggatgttttt gtaagttaat tttctaagac   4559

 tttttcacat ccaaagtgat gctttgcttt gggttttaac tgtttggcca cggcgggggt   4619

 gggggcgggg ggttggtaca aaaacttgaa gctgtttgtg atatgtacaa ctcagatgtt   4679

 tctcattaaa aaacaaaatt agccagaaaa aaaaaaaa                           4717




      <210> 309
      <211> 1164
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (191)..(763)

      <220>
      <221> misc_feature
      <222> (1)...(1164)
      <223> n = a,t,c or g

      <400> 309
 aaggatcctt aattttatta tccccccccc ccgagctgcc actgctgtag cttctgccac     60

 ctgccacgac cgggcctctc cctggcgttt ggtcacctct gcttcattct ccaccgcgcc    120

 tatggtccct cttggagcca gcgtggcggg cctggcggct cccgggtggt gagagagcgg    180

 tccgggaacg   atg aag gcc tcg cag tgc tgc tgc tgt ctc agc cac ctc     229
              Met Lys Ala Ser Gln Cys Cys Cys Cys Leu Ser His Leu
                1               5                  10

 ttg gct tcc gtc ctc ctc ctg ctg ttg ctg cct gaa cta agc ggg ccc      277
 Leu Ala Ser Val Leu Leu Leu Leu Leu Leu Pro Glu Leu Ser Gly Pro
      15                  20                  25

 ctg gca gtc ctg ctg cag gca gcc gag gcc gcg cca ggt ctt ggg cct      325
 Leu Ala Val Leu Leu Gln Ala Ala Glu Ala Ala Pro Gly Leu Gly Pro
  30                  35                  40                  45

 cct gac cct aga cca cgg aca tta ccg ccg ctg cca ccg ggc cct acc      373
 Pro Asp Pro Arg Pro Arg Thr Leu Pro Pro Leu Pro Pro Gly Pro Thr
                  50                  55                  60

 cct gcc cag cag ccg ggc cgt ggt ctg gct gaa gct gcg ggg ccg cgg      421
 Pro Ala Gln Gln Pro Gly Arg Gly Leu Ala Glu Ala Ala Gly Pro Arg
              65                  70                  75

 ggc tcc gag gga ggc aat ggc agc aac cct gtg gcc ggg ctt gag acg      469
 Gly Ser Glu Gly Gly Asn Gly Ser Asn Pro Val Ala Gly Leu Glu Thr
          80                  85                  90

 gac gat cac gga ggg aag gcc ggg gaa ggc tcg gtg ggt ggc ggc ctt      517
 Asp Asp His Gly Gly Lys Ala Gly Glu Gly Ser Val Gly Gly Gly Leu
      95                 100                 105

 gct gtg agc ccc aac cct ggc gac aag ccc atg acc cag cgg gcc ctg      565
 Ala Val Ser Pro Asn Pro Gly Asp Lys Pro Met Thr Gln Arg Ala Leu
 110                 115                 120                 125

 acc gtg ttg atg gtg gtg agc ggc gcg gtg ctg gtg tac ttc gtg gtc      613
 Thr Val Leu Met Val Val Ser Gly Ala Val Leu Val Tyr Phe Val Val
                 130                 135                 140

 agg acg gtc agg atg aga aga aga aac cga aag act agg aga tat gga      661
 Arg Thr Val Arg Met Arg Arg Arg Asn Arg Lys Thr Arg Arg Tyr Gly
             145                 150                 155

 gtt ttg gac act aac ata gaa aat atg gaa ttg aca cct tta gaa cag      709
 Val Leu Asp Thr Asn Ile Glu Asn Met Glu Leu Thr Pro Leu Glu Gln
         160                 165                 170

 gat gat gag gat gat gac aac acg ttg ttt gat gcc aat cat cct cga      757
 Asp Asp Glu Asp Asp Asp Asn Thr Leu Phe Asp Ala Asn His Pro Arg
     175                 180                 185

 aga taa gaatgtgcct tttgatgaaa gaactttatc tttctacaat gaagagtgga       813
 Arg 
 190

 atttctatgt ttaaggaata agaagccact atatcaatgt tgggggggta tttaagttac    873

 atatatttta acaaccttta atttgctgtt gcaataaata ccgtatcctt ttattatatc    933

 tttatatgta tagaagtact ctgttaatgg gctcagagat gttggggata aagtatactg    993

 taataattta tctgtttgaa aattactata aaacggtgtt ttctgatcgg tttttgtttc   1053

 ctgcttacca tatgattgta aattgttnta tgtattaatc agttaatgct taatattttt   1113

 gctgatgtca tatgttaaag agctttttcc aacaccctgg gggtgtattt t            1164




      <210> 310
      <211> 1898
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (458)..(1321)

      <400> 310
 cctcactgcg ctaggagccc cactaaaccc agcggagcgg agcctggcgg gaggcagcgc     60

 cgcggagcca gcgccggacg ccgcaagcag actccccggc cagcgcaagc actccctggc    120

 cggcgccgga ccctcggggc gccggattcg tcttgtgtgc cccacgtcat gcgcgcgggc    180

 gtccgcggct ctcccgacca gccccagcgc ggtgggccca ggctcagagg tcccggcgcc    240

 tctcgctgaa gtagttgggt agccggggct gggggtcgcc acgtcggggg cgcggccagg    300

 acccgcggag ccggtccccg agcgcgggga gcggggccgc ccgcgccgcc ccaccattac    360

 ctccccgggc ggcaaggagg agctggtggc ggtcgcctcc cggctgtggc agcggcggcg    420

 gcgtgcctgc ctggcggccg tcggcgtact cttggcc atg gcg ctc ggg ctg ctc     475
                                          Met Ala Leu Gly Leu Leu
                                            1               5

 atc gcc gtg ccg ctg ctg ctg cag gcg gcg ccc cga ggc gcc gcg cac      523
 Ile Ala Val Pro Leu Leu Leu Gln Ala Ala Pro Arg Gly Ala Ala His
              10                  15                  20

 tat gag atg atg ggc acc tgc cgc atg atc tgc gac cct tac act gcc      571
 Tyr Glu Met Met Gly Thr Cys Arg Met Ile Cys Asp Pro Tyr Thr Ala
          25                  30                  35

 gcg ccc ggc ggg gag ccc ccg ggt gca aag gcg cag cca ccc gga ccc      619
 Ala Pro Gly Gly Glu Pro Pro Gly Ala Lys Ala Gln Pro Pro Gly Pro
      40                  45                  50

 agc acc gcc gcc ctg gaa gtc atg cag gac ctc agc gcc aac cct cct      667
 Ser Thr Ala Ala Leu Glu Val Met Gln Asp Leu Ser Ala Asn Pro Pro
  55                  60                  65                  70

 cct cct ttc atc cag gga ccc aag ggc gac ccg ggg cga ccg ggc aag      715
 Pro Pro Phe Ile Gln Gly Pro Lys Gly Asp Pro Gly Arg Pro Gly Lys
                  75                  80                  85

 cca ggg ccg cgg ggg ccc cct gga gag ccg ggc ccg cct gga ccc agg      763
 Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly Pro Arg
              90                  95                 100

 ggc cct ccg gga gag aag ggc gac tcg ggg agg ccc ggg ctg cca ggg      811
 Gly Pro Pro Gly Glu Lys Gly Asp Ser Gly Arg Pro Gly Leu Pro Gly
         105                 110                 115

 ctg caa ctg acg gcg ggc acg gcc agc ggc gtc ggg gtg gtg ggc ggc      859
 Leu Gln Leu Thr Ala Gly Thr Ala Ser Gly Val Gly Val Val Gly Gly
     120                 125                 130

 ggg gcc ggg gta ggt ggc gat tcc gag ggt gaa gtg acc agt gcg ctg      907
 Gly Ala Gly Val Gly Gly Asp Ser Glu Gly Glu Val Thr Ser Ala Leu
 135                 140                 145                 150

 agc gcc acc ttc agc ggc ccc aag atc gcc ttc tat gtg ggt ctc aag      955
 Ser Ala Thr Phe Ser Gly Pro Lys Ile Ala Phe Tyr Val Gly Leu Lys
                 155                 160                 165

 agc ccc cac gaa ggc tat gag gtg ctg aag ttc gat gac gtg gtc acc     1003
 Ser Pro His Glu Gly Tyr Glu Val Leu Lys Phe Asp Asp Val Val Thr
             170                 175                 180

 aac ctc ggc aat cac tat gac ccc acc acg ggc aag ttc agc tgc cag     1051
 Asn Leu Gly Asn His Tyr Asp Pro Thr Thr Gly Lys Phe Ser Cys Gln
         185                 190                 195

 gta cgc ggc atc tac ttc ttc acc tac cac atc ctc atg cgc ggc ggc     1099
 Val Arg Gly Ile Tyr Phe Phe Thr Tyr His Ile Leu Met Arg Gly Gly
     200                 205                 210

 gac ggc acc agc atg tgg gcg gac ctc tgc aag aac ggg cag gtc cgg     1147
 Asp Gly Thr Ser Met Trp Ala Asp Leu Cys Lys Asn Gly Gln Val Arg
 215                 220                 225                 230

 gcc agc gcc att gca cag gac gcc gac cag aac tac gac tac gcc agt     1195
 Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln Asn Tyr Asp Tyr Ala Ser
                 235                 240                 245

 aac agc gtg gtg ctg cac ttg gat tca ggg gac gaa gtg tat gtg aag     1243
 Asn Ser Val Val Leu His Leu Asp Ser Gly Asp Glu Val Tyr Val Lys
             250                 255                 260

 ctg gat ggc ggg aag gct cac gga ggc aat aat aac aag tac agc acg     1291
 Leu Asp Gly Gly Lys Ala His Gly Gly Asn Asn Asn Lys Tyr Ser Thr
         265                 270                 275

 ttc tcg ggc ttt ctt ctg tac ccg gat tag g ggcgcggggg gtgcgaggcg     1342
 Phe Ser Gly Phe Leu Leu Tyr Pro Asp 
     280                 285

 gggtggctgc aggccgcccg gtctccgccc gggcgcggct ccttggcaaa ggccactctc   1402

 gattcataac acttcctgac atctcctttg gaaaagacaa atccctgcgt cctccctgcc   1462

 ccgctcctgg cctcagtgcg tctgcgaccc accacgctca gggctgtgct cctggtctcc   1522

 atccccatcc cggcaaggga ggaagggacg cccgagccct tgaggcggcg gcacagactt   1582

 tgcaaacctg attagactgg acaggcaggg ccgggagcct gccctcctca gacagcctcc   1642

 tcccagtgcc tagaagcgga gggctccggg ccctggccag ggaggtaggc cagagggagc   1702

 gcgggcttcc tggggcgtcc ttctttgtga cccgaaatac ttgtgcagat ttccctgtcc   1762

 atcagccaaa accccaccca cagcagaatt ccagcaaaca gaaaattcac ctctccacac   1822

 cgcattccct cctgactcag actcaccgcg atgcattaaa ttatgttttt agactttgaa   1882

 aaaaaaaaaa aaaaaa                                                   1898




      <210> 311
      <211> 1492
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (337)..(1374)

      <400> 311
 gaattcccca ccagagcctg gtgatgtggt tgtacctgct gctatcagtg gtcaattctg     60

 tgtgctgagg cccacaaaga agtcacattt ctttctctga agatgataaa agcggaggca    120

 tctctcaatc tggaaggggc tagctgggca tgaaggtggt ggcagaggct cccctagacc    180

 ccggtttgca ccgttcctct ggcactgtgg gacagaagtg gacttgctgg aagccaggag    240

 atcacatgaa tgttaatgat caccttgttg tggtctttgc cctagagtga cagcccgtgc    300

 ttcaaagagc atgaatatac ggagtttggg aaatgg  atg gat ggc tgg gag acc     354
                                          Met Asp Gly Trp Glu Thr
                                            1               5

 agg agg aaa agg att cca ggt cac gac tgg tgt gtc ctc agg ctg ggg      402
 Arg Arg Lys Arg Ile Pro Gly His Asp Trp Cys Val Leu Arg Leu Gly
              10                  15                  20

 atc caa gga gtc atc cgg ggc ttc gac gtg gac gtt tct tac ttc acg      450
 Ile Gln Gly Val Ile Arg Gly Phe Asp Val Asp Val Ser Tyr Phe Thr
          25                  30                  35

 gga gat tac gct cct cga gtg tcc att caa gca gca aac ttg gaa gaa      498
 Gly Asp Tyr Ala Pro Arg Val Ser Ile Gln Ala Ala Asn Leu Glu Glu
      40                  45                  50

 gat aaa cta cca gaa atc cca gaa aga gga acc agg aca gga gct gca      546
 Asp Lys Leu Pro Glu Ile Pro Glu Arg Gly Thr Arg Thr Gly Ala Ala
  55                  60                  65                  70

 gcc act cct gag gag ttt gaa gcc att gct gag cta aaa tcc gac gac      594
 Ala Thr Pro Glu Glu Phe Glu Ala Ile Ala Glu Leu Lys Ser Asp Asp
                  75                  80                  85

 tgg agt tac ttg gtt ccc atg act gag ctt aag cca gga aac cct gct      642
 Trp Ser Tyr Leu Val Pro Met Thr Glu Leu Lys Pro Gly Asn Pro Ala
              90                  95                 100

 tcc ggc cac aac tat ttt ctt gtc aat tcc cag cag aga tgg act cat      690
 Ser Gly His Asn Tyr Phe Leu Val Asn Ser Gln Gln Arg Trp Thr His
         105                 110                 115

 atc aga ctc aac att ttc cca gat ggt gga att gca cga ctt aga gta      738
 Ile Arg Leu Asn Ile Phe Pro Asp Gly Gly Ile Ala Arg Leu Arg Val
     120                 125                 130

 ttc ggt act gga caa aaa gac tgg act gca act gac ccc aaa gaa cct      786
 Phe Gly Thr Gly Gln Lys Asp Trp Thr Ala Thr Asp Pro Lys Glu Pro
 135                 140                 145                 150

 gca gac cta gtg gcc atc gct ttt ggg ggt gtc tgt gta gga tta agt      834
 Ala Asp Leu Val Ala Ile Ala Phe Gly Gly Val Cys Val Gly Leu Ser
                 155                 160                 165

 aat gct aag ttt ggg cac cca aac aat ata ata gga gtt ggc ggg gca      882
 Asn Ala Lys Phe Gly His Pro Asn Asn Ile Ile Gly Val Gly Gly Ala
             170                 175                 180

 aag tct atg gcg gat ggt tgg gaa act gca aga agg ctg gac cgg cca      930
 Lys Ser Met Ala Asp Gly Trp Glu Thr Ala Arg Arg Leu Asp Arg Pro
         185                 190                 195

 cca ata tta gaa aat gat gag aat ggc att ctc ttg gtt ccg ggt tgt      978
 Pro Ile Leu Glu Asn Asp Glu Asn Gly Ile Leu Leu Val Pro Gly Cys
     200                 205                 210

 gaa tgg gca gtt ttc cga ttg gca cat cct gga gta ata act cga att     1026
 Glu Trp Ala Val Phe Arg Leu Ala His Pro Gly Val Ile Thr Arg Ile
 215                 220                 225                 230

 gaa att gac aca aaa tat ttt gaa ggc aat gct cct gac agc tgt aaa     1074
 Glu Ile Asp Thr Lys Tyr Phe Glu Gly Asn Ala Pro Asp Ser Cys Lys
                 235                 240                 245

 gtg gat ggg tgc atc ctg aca act cag gaa gaa gcc gtg atc agg caa     1122
 Val Asp Gly Cys Ile Leu Thr Thr Gln Glu Glu Ala Val Ile Arg Gln
             250                 255                 260

 aag tgg att ctc ccg gcc cac aag tgg aaa cca ctg ctt cca gtg acc     1170
 Lys Trp Ile Leu Pro Ala His Lys Trp Lys Pro Leu Leu Pro Val Thr
         265                 270                 275

 aag ttg tct ccc aac caa agt cat ctg ttc gat agc ctg acc cta gag     1218
 Lys Leu Ser Pro Asn Gln Ser His Leu Phe Asp Ser Leu Thr Leu Glu
     280                 285                 290

 ctc caa gat gtc atc act cac gcc agg ctc acc atc gtc ccc gac ggg     1266
 Leu Gln Asp Val Ile Thr His Ala Arg Leu Thr Ile Val Pro Asp Gly
 295                 300                 305                 310

 gga gtg agc cgc ctt cgg ctc cgg ggc ttc ccc agc tcc atc tgc ctc     1314
 Gly Val Ser Arg Leu Arg Leu Arg Gly Phe Pro Ser Ser Ile Cys Leu
                 315                 320                 325

 ctg agg ccc cgg gag aag ccc atg ttg aag ttc tcg gtg agc ttc aaa     1362
 Leu Arg Pro Arg Glu Lys Pro Met Leu Lys Phe Ser Val Ser Phe Lys
             330                 335                 340

 gca aac cct taa cac acacaaagcc ccggtgtcgg acacacagca gtaatttccc     1417
 Ala Asn Pro 
         345

 agtcatagtc ttcttttcaa atgttttgaa cacctggtga tttaataaag tggtcgtctc   1477

 acaaaaaaaa aaaaa                                                    1492




      <210> 312
      <211> 1872
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (231)..(1808)

      <400> 312
 tcaggctgcc tgatctgccc agctttccag ctttcctctg gattccggcc tctggtcatc     60

 cctccccacc ctctctccaa ggccctctcc tggtctccct tcttctagaa ccccttcctc    120

 cacctccctc tctgcagaac ttctccttta ccccccaccc cccaccactg ccccctttcc    180

 ttttctgacc tccttttgga gggctcagcg ctgcccagac cataggagag   atg tgg     236
                                                          Met Trp
                                                            1

 gag gct cag ttc ctg ggc ttg ctg ttt ctg cag ccg ctt tgg gtg gct      284
 Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp Val Ala
           5                  10                  15

 cca gtg aag cct ctc cag cca ggg gct gag gtc ccg gtg gtg tgg gcc      332
 Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val Trp Ala
      20                  25                  30

 cag gag ggg gct cct gcc cag ctc ccc tgc agc ccc aca atc ccc ctc      380
 Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile Pro Leu
  35                  40                  45                  50

 cag gat ctc agc ctt ctg cga aga gca ggg gtc act tgg cag cat cag      428
 Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln His Gln
                  55                  60                  65

 cca gac agt ggc ccg ccc gct gcc gcc ccc ggc cat ccc ctg gcc ccc      476
 Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu Ala Pro
              70                  75                  80

 ggc cct cac ccg gcg gcg ccc tcc tcc tgg ggg ccc agg ccc cgc cgc      524
 Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro Arg Arg
          85                  90                  95

 tac acg gtg ctg agc gtg ggt ccc gga ggc ctg cgc agc ggg agg ctg      572
 Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly Arg Leu
     100                 105                 110

 ccc ctg cag ccc cgc gtc cag ctg gat gag cgc ggc cgg cag cgc ggg      620
 Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln Arg Gly
 115                 120                 125                 130

 gac ttc tcg cta tgg ctg cgc cca gcc cgg cgc gcg gac gcc ggc gag      668
 Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala Gly Glu
                 135                 140                 145

 tac cgc gcc gcg gtg cac ctc agg gac cgc gcc ctc tcc tgc cgc ctc      716
 Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys Arg Leu
             150                 155                 160

 cgt ctg cgc ctg ggc cag gcc tcg atg act gcc agc ccc cca gga tct      764
 Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro Gly Ser
         165                 170                 175

 ctc aga gcc tcc gac tgg gtc att ttg aac tgc tcc ttc agc cgc cct      812
 Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser Arg Pro
     180                 185                 190

 gac cgc cca gcc tct gtg cat tgg ttc cgg aac cgg ggc cag ggc cga      860
 Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln Gly Arg
 195                 200                 205                 210

 gtc cct gtc cgg gag tcc ccc cat cac cac tta gcg gaa agc ttc ctc      908
 Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser Phe Leu
                 215                 220                 225

 ttc ctg ccc caa gtc agc ccc atg gac tct ggg ccc tgg ggc tgc atc      956
 Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly Cys Ile
             230                 235                 240

 ctc acc tac aga gat ggc ttc aac gtc tcc atc atg tat aac ctc act     1004
 Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn Leu Thr
         245                 250                 255

 gtt ctg ggt ctg gag ccc cca act ccc ttg aca gtg tac gct gga gca     1052
 Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala Gly Ala
     260                 265                 270

 ggt tcc agg gtg ggg ctg ccc tgc cgc ctg cct gct ggt gtg ggg acc     1100
 Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val Gly Thr
 275                 280                 285                 290

 cgg tct ttc ctc act gcc aag tgg act cct cct ggg gga ggc cct gac     1148
 Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro Asp
                 295                 300                 305

 ctc ctg gtg act gga gac aat ggc gac ttt acc ctt cga cta gag gat     1196
 Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu Glu Asp
             310                 315                 320

 gtg agc cag gcc cag gct ggg acc tac acc tgc cat atc cat ctg cag     1244
 Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His Leu Gln
         325                 330                 335

 gaa cag cag ctc aat gcc act gtc aca ttg gca atc atc aca gtg act     1292
 Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr Val Thr
     340                 345                 350

 ccc aaa tcc ttt ggg tca cct gga tcc ctg ggg aag ctg ctt tgt gag     1340
 Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu Cys Glu
 355                 360                 365                 370

 gtg act cca gta tct gga caa gaa cgc ttt gtg tgg agc tct ctg gac     1388
 Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser Leu Asp
                 375                 380                 385

 acc cca tcc cag agg agt ttc tca gga cct tgg ctg gag gca cag gag     1436
 Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala Gln Glu
             390                 395                 400

 gcc cag ctc ctt tcc cag cct tgg caa tgc cag ctg tac cag ggg gag     1484
 Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln Gly Glu
         405                 410                 415

 agg ctt ctt gga gca gca gtg tac ttc aca gag ctg tct agc cca ggt     1532
 Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser Pro Gly
     420                 425                 430

 gcc caa cgc tct ggg aga gcc cca ggt gcc ctc cca gca ggc cac ctc     1580
 Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly His Leu
 435                 440                 445                 450

 ctg ctg ttt ctc acc ctt ggt gtc ctt tct ctg ctc ctt ttg gtg act     1628
 Leu Leu Phe Leu Thr Leu Gly Val Leu Ser Leu Leu Leu Leu Val Thr
                 455                 460                 465

 gga gcc ttt ggc ttt cac ctt tgg aga aga cag tgg cga cca aga cga     1676
 Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro Arg Arg
             470                 475                 480

 ttt tct gcc tta gag caa ggg att cac cct cgc cag gct cag agc aag     1724
 Phe Ser Ala Leu Glu Gln Gly Ile His Pro Arg Gln Ala Gln Ser Lys
         485                 490                 495

 ata gag gag ctg gag caa gaa ccg gag ccg gag ccg gag ccg gaa ccg     1772
 Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro
     500                 505                 510

 gag ccc gag ccc gag ccc gag ccg gag cag ctc tga cctg gagctgaggc     1822
 Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
 515                 520                 525

 agccagcaga tctcagcagc ccagtccaaa taaacgtcct gtctagcagc              1872




      <210> 313
      <211> 3857
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (147)..(3857)

      <400> 313
 atagaaaagc tgtgacgcct gcacgtaccg gtccggaatt cccgggtcga cgatttcgtg     60

 tcgcgccctc gagggagcca gctgggccat ggccgcgagg caggggtgag accggcggcc    120

 acccgggagc cctccgcacc cgcacc atg cag aag agc gtg cgc tac aac gag     173
                              Met Gln Lys Ser Val Arg Tyr Asn Glu
                                1               5

 ggg cac gcc ctg tac ctg gcc ttt ctg gcg cgc aag gag ggc acc aag      221
 Gly His Ala Leu Tyr Leu Ala Phe Leu Ala Arg Lys Glu Gly Thr Lys
  10                  15                  20                  25

 cgc ggc ttc ctg agt aag aag acg gcc gag gcg agc cgc tgg cac gag      269
 Arg Gly Phe Leu Ser Lys Lys Thr Ala Glu Ala Ser Arg Trp His Glu
                  30                  35                  40

 aag tgg ttc gcc ctc tac cag aat gtg ctc ttc tac ttc gag ggc gag      317
 Lys Trp Phe Ala Leu Tyr Gln Asn Val Leu Phe Tyr Phe Glu Gly Glu
              45                  50                  55

 cag agc tgc cgc ccg gcg ggc atg tac ctc ctg gag ggc tgc agc tgc      365
 Gln Ser Cys Arg Pro Ala Gly Met Tyr Leu Leu Glu Gly Cys Ser Cys
          60                  65                  70

 gaa cga acg ccc gcg cca ccc agg gcc ggc gcc ggg cag gga ggc gtc      413
 Glu Arg Thr Pro Ala Pro Pro Arg Ala Gly Ala Gly Gln Gly Gly Val
      75                  80                  85

 cga gac gcg ctg gac aag cag tat tac ttt act gtt ctt ttt ggc cat      461
 Arg Asp Ala Leu Asp Lys Gln Tyr Tyr Phe Thr Val Leu Phe Gly His
  90                  95                 100                 105

 gaa ggt cag aag cca ctg gag ctg cgc tgt gag gag gag cag gat ggt      509
 Glu Gly Gln Lys Pro Leu Glu Leu Arg Cys Glu Glu Glu Gln Asp Gly
                 110                 115                 120

 aaa gag tgg atg gag gcc att cac caa gcc agt tat gca gac att ttg      557
 Lys Glu Trp Met Glu Ala Ile His Gln Ala Ser Tyr Ala Asp Ile Leu
             125                 130                 135

 att gag agg gaa gta tta atg cag aag tac att cat cta gtt cag atc      605
 Ile Glu Arg Glu Val Leu Met Gln Lys Tyr Ile His Leu Val Gln Ile
         140                 145                 150

 gta gag aca gaa aaa att gca gct aac caa ctc cga cat caa ctt gaa      653
 Val Glu Thr Glu Lys Ile Ala Ala Asn Gln Leu Arg His Gln Leu Glu
     155                 160                 165

 gat caa gac aca gaa atc gaa agg ctt aaa tca gag att att gct ctt      701
 Asp Gln Asp Thr Glu Ile Glu Arg Leu Lys Ser Glu Ile Ile Ala Leu
 170                 175                 180                 185

 aat aaa acc aaa gaa cga atg cga cct tac caa agc aac caa gaa gac      749
 Asn Lys Thr Lys Glu Arg Met Arg Pro Tyr Gln Ser Asn Gln Glu Asp
                 190                 195                 200

 gaa gat cca gac atc aag aag att aaa aag gtt cag agc ttc atg cga      797
 Glu Asp Pro Asp Ile Lys Lys Ile Lys Lys Val Gln Ser Phe Met Arg
             205                 210                 215

 gga tgg ttg tgc aga agg aaa tgg aag acc atc gtg cag gat tac att      845
 Gly Trp Leu Cys Arg Arg Lys Trp Lys Thr Ile Val Gln Asp Tyr Ile
         220                 225                 230

 tgt tct cct cat gct gaa agt atg agg aag aga aac cag att gtg ttc      893
 Cys Ser Pro His Ala Glu Ser Met Arg Lys Arg Asn Gln Ile Val Phe
     235                 240                 245

 acc atg gtg gag gca gag tca gag tac gtt cac cag ctc tac atc ctg      941
 Thr Met Val Glu Ala Glu Ser Glu Tyr Val His Gln Leu Tyr Ile Leu
 250                 255                 260                 265

 gtc aat ggc ttt ctc cgg ccc ctg cgt atg gcc gcc agc tcc aag aag      989
 Val Asn Gly Phe Leu Arg Pro Leu Arg Met Ala Ala Ser Ser Lys Lys
                 270                 275                 280

 ccc ccc atc agc cac gac gac gtc agc agt att ttt ctt aac agt gaa     1037
 Pro Pro Ile Ser His Asp Asp Val Ser Ser Ile Phe Leu Asn Ser Glu
             285                 290                 295

 aca atc atg ttt ctt cat gaa ata ttt cat caa gga cta aag gca agg     1085
 Thr Ile Met Phe Leu His Glu Ile Phe His Gln Gly Leu Lys Ala Arg
         300                 305                 310

 ata gca aac tgg ccc act tta att tta gct gat ctg ttt gat att ttg     1133
 Ile Ala Asn Trp Pro Thr Leu Ile Leu Ala Asp Leu Phe Asp Ile Leu
     315                 320                 325

 ctc ccc atg ctg aac att tat caa gaa ttt gtg cgt aat cac cag tac     1181
 Leu Pro Met Leu Asn Ile Tyr Gln Glu Phe Val Arg Asn His Gln Tyr
 330                 335                 340                 345

 agc ctg caa gtt ctc gcc aat tgt aag caa aac aga gat ttt gac aaa     1229
 Ser Leu Gln Val Leu Ala Asn Cys Lys Gln Asn Arg Asp Phe Asp Lys
                 350                 355                 360

 ctc tta aaa cag tat gaa gcc aat cca gcc tgt gag ggg agg atg ctg     1277
 Leu Leu Lys Gln Tyr Glu Ala Asn Pro Ala Cys Glu Gly Arg Met Leu
             365                 370                 375

 gag aca ttc ttg acc tat ccc atg ttt cag atc ccc aga tat atc atc     1325
 Glu Thr Phe Leu Thr Tyr Pro Met Phe Gln Ile Pro Arg Tyr Ile Ile
         380                 385                 390

 aca ctc cat gag ctc ctt gct cac aca ccc cat gag cat gtg gaa agg     1373
 Thr Leu His Glu Leu Leu Ala His Thr Pro His Glu His Val Glu Arg
     395                 400                 405

 aaa agc ctg gag ttt gcc aaa tca aag cta gag gaa cta tcc aga gta     1421
 Lys Ser Leu Glu Phe Ala Lys Ser Lys Leu Glu Glu Leu Ser Arg Val
 410                 415                 420                 425

 atg cac gat gaa gtc agc gac act gaa aac ata agg aaa aac ctt gcc     1469
 Met His Asp Glu Val Ser Asp Thr Glu Asn Ile Arg Lys Asn Leu Ala
                 430                 435                 440

 atc gaa aga atg atc gtg gag ggc tgt gac atc ttg ctg gac acc agc     1517
 Ile Glu Arg Met Ile Val Glu Gly Cys Asp Ile Leu Leu Asp Thr Ser
             445                 450                 455

 caa acg ttc atc cgc caa ggt tct ctt att caa gta cct tcc gtt gag     1565
 Gln Thr Phe Ile Arg Gln Gly Ser Leu Ile Gln Val Pro Ser Val Glu
         460                 465                 470

 agg ggg aaa ctt agt aaa gtt cgc ctg ggt tcg ttg tct ttg aaa aag     1613
 Arg Gly Lys Leu Ser Lys Val Arg Leu Gly Ser Leu Ser Leu Lys Lys
     475                 480                 485

 gaa gga gag aga caa tgc ttc tta ttt aca aaa cac ttt tta ata tgt     1661
 Glu Gly Glu Arg Gln Cys Phe Leu Phe Thr Lys His Phe Leu Ile Cys
 490                 495                 500                 505

 aca aga agt tca gga ggg aag ctt cat ctg ctc aag aca ggt ggg gtt     1709
 Thr Arg Ser Ser Gly Gly Lys Leu His Leu Leu Lys Thr Gly Gly Val
                 510                 515                 520

 ctg tct cta ata gac tgc aca ttg att gag gag cca gat gca agc gat     1757
 Leu Ser Leu Ile Asp Cys Thr Leu Ile Glu Glu Pro Asp Ala Ser Asp
             525                 530                 535

 gat gac tct aaa ggt tct ggg caa gtg ttt ggg cac ctg gat ttt aaa     1805
 Asp Asp Ser Lys Gly Ser Gly Gln Val Phe Gly His Leu Asp Phe Lys
         540                 545                 550

 ata gtg gtg gag cct cct gac cgt gcc gcc ttc act gtt gtc ttg tta     1853
 Ile Val Val Glu Pro Pro Asp Arg Ala Ala Phe Thr Val Val Leu Leu
     555                 560                 565

 gca ccc tca cgc cag gag aaa gct gcc tgg atg agt gac atc agt cag     1901
 Ala Pro Ser Arg Gln Glu Lys Ala Ala Trp Met Ser Asp Ile Ser Gln
 570                 575                 580                 585

 tgt gtg gac aat ata cga tgt aat ggt tta atg act ata gtg ttt gaa     1949
 Cys Val Asp Asn Ile Arg Cys Asn Gly Leu Met Thr Ile Val Phe Glu
                 590                 595                 600

 gag aat tcc aaa gtc act gtg cca cat atg att aag tct gat gcc cgt     1997
 Glu Asn Ser Lys Val Thr Val Pro His Met Ile Lys Ser Asp Ala Arg
             605                 610                 615

 ctt cat aaa gac gac act gac att tgc ttc agt aaa aca ctc aac tcc     2045
 Leu His Lys Asp Asp Thr Asp Ile Cys Phe Ser Lys Thr Leu Asn Ser
         620                 625                 630

 tgc aaa gtg ccc cag atc cgt tat gcc agc gtg gag cgc ctc ttg gaa     2093
 Cys Lys Val Pro Gln Ile Arg Tyr Ala Ser Val Glu Arg Leu Leu Glu
     635                 640                 645

 cga ctg aca gac ttg cgg ttt ctt agt att gat ttc ctc aac acc ttt     2141
 Arg Leu Thr Asp Leu Arg Phe Leu Ser Ile Asp Phe Leu Asn Thr Phe
 650                 655                 660                 665

 ctg cac acc tat cgt att ttc act act gcc gct gtg gtg ctg ggg aaa     2189
 Leu His Thr Tyr Arg Ile Phe Thr Thr Ala Ala Val Val Leu Gly Lys
                 670                 675                 680

 ctc tcc gac ata tac aag agg cct ttc acc tcc atc cct gtc agg tca     2237
 Leu Ser Asp Ile Tyr Lys Arg Pro Phe Thr Ser Ile Pro Val Arg Ser
             685                 690                 695

 ttg gaa ttg ttt ttt gct acc agc cag aac aac aga ggt gaa cat ttg     2285
 Leu Glu Leu Phe Phe Ala Thr Ser Gln Asn Asn Arg Gly Glu His Leu
         700                 705                 710

 gtg gat ggc aaa tcc cca cgt ctg tgt cgc aaa ttc tct tcc ccg cca     2333
 Val Asp Gly Lys Ser Pro Arg Leu Cys Arg Lys Phe Ser Ser Pro Pro
     715                 720                 725

 cca ctg gct gtg tcc aga aca tct tcc cca gtg agg gcc aga aag ctg     2381
 Pro Leu Ala Val Ser Arg Thr Ser Ser Pro Val Arg Ala Arg Lys Leu
 730                 735                 740                 745

 tct ttg act tct ccc ttg aac tca aag ata gga gca ttg gac ctg aca     2429
 Ser Leu Thr Ser Pro Leu Asn Ser Lys Ile Gly Ala Leu Asp Leu Thr
                 750                 755                 760

 act tcc agc agt ccc acc acc acc acc cag agt ccc gct gcg tct cca     2477
 Thr Ser Ser Ser Pro Thr Thr Thr Thr Gln Ser Pro Ala Ala Ser Pro
             765                 770                 775

 cca cca cac act ggt cag ata cca ctg gat ctc agc aga ggc ctc tct     2525
 Pro Pro His Thr Gly Gln Ile Pro Leu Asp Leu Ser Arg Gly Leu Ser
         780                 785                 790

 tct cca gag caa agc ccg gga acg gta gaa gag aat gtc gat aac cca     2573
 Ser Pro Glu Gln Ser Pro Gly Thr Val Glu Glu Asn Val Asp Asn Pro
     795                 800                 805

 cgc gtg gat ctg tgt aac aag cta aaa cga agt att caa gca gca gtc     2621
 Arg Val Asp Leu Cys Asn Lys Leu Lys Arg Ser Ile Gln Ala Ala Val
 810                 815                 820                 825

 cta gag tct gca cca gcg gac cga gca gga gtg gaa agc tcc cct gca     2669
 Leu Glu Ser Ala Pro Ala Asp Arg Ala Gly Val Glu Ser Ser Pro Ala
                 830                 835                 840

 gcg gac acc aca gaa ctt tca cct tgc aga tcc ccc tca act cct cgg     2717
 Ala Asp Thr Thr Glu Leu Ser Pro Cys Arg Ser Pro Ser Thr Pro Arg
             845                 850                 855

 cac ctc cgc tat cga cag cct gga gga cag acg gcg gac aat gcc cac     2765
 His Leu Arg Tyr Arg Gln Pro Gly Gly Gln Thr Ala Asp Asn Ala His
         860                 865                 870

 tgc tct gtt tca ccg gct tct gct ttt gca ata gcc aca gct gca gca     2813
 Cys Ser Val Ser Pro Ala Ser Ala Phe Ala Ile Ala Thr Ala Ala Ala
     875                 880                 885

 gga cat ggg agt cca cca ggc ttt aac aac acc gag aga aca tgt gat     2861
 Gly His Gly Ser Pro Pro Gly Phe Asn Asn Thr Glu Arg Thr Cys Asp
 890                 895                 900                 905

 aaa gag ttt att ata cgg aga acg gct acc aat cga gtt ctg aac gtc     2909
 Lys Glu Phe Ile Ile Arg Arg Thr Ala Thr Asn Arg Val Leu Asn Val
                 910                 915                 920

 ctc cgt cac tgg gtc tca aag cac gca cag gat ttc gaa ctc aac aat     2957
 Leu Arg His Trp Val Ser Lys His Ala Gln Asp Phe Glu Leu Asn Asn
             925                 930                 935

 gaa cta aag atg aat gtc cta aat ttg cta gaa gaa gtt ttg cga gac     3005
 Glu Leu Lys Met Asn Val Leu Asn Leu Leu Glu Glu Val Leu Arg Asp
         940                 945                 950

 cca gac ctt ctt ccc caa gaa agg aaa gcc gcc gcg aat atc ctc agg     3053
 Pro Asp Leu Leu Pro Gln Glu Arg Lys Ala Ala Ala Asn Ile Leu Arg
     955                 960                 965

 gcc ctt tca caa gat gac caa gat gac atc cac cta aaa tta gag gat     3101
 Ala Leu Ser Gln Asp Asp Gln Asp Asp Ile His Leu Lys Leu Glu Asp
 970                 975                 980                 985

 ata att caa atg act gac tgc atg aag gcc gaa tgc ttt gag tcc ttg     3149
 Ile Ile Gln Met Thr Asp Cys Met Lys Ala Glu Cys Phe Glu Ser Leu
                 990                 995                1000

 tcg gcc atg gag ctg gca gaa cag atc acc ctc ctg gac cat gtc att     3197
 Ser Ala Met Glu Leu Ala Glu Gln Ile Thr Leu Leu Asp His Val Ile
            1005                1010                1015

 ttc aga agc att ccc tac gag gag ttt ctt ggg cag ggg tgg atg aag     3245
 Phe Arg Ser Ile Pro Tyr Glu Glu Phe Leu Gly Gln Gly Trp Met Lys
        1020                1025                1030

 ctg gat aaa aac gaa aga act cct tac att atg aaa acc agc caa cac     3293
 Leu Asp Lys Asn Glu Arg Thr Pro Tyr Ile Met Lys Thr Ser Gln His
    1035                1040                1045

 ttc aat gac atg agt aac ctg gtg gcc tcc cag ata atg aac tat gct     3341
 Phe Asn Asp Met Ser Asn Leu Val Ala Ser Gln Ile Met Asn Tyr Ala
1050                1055                1060                1065

 gat gtc agc tcc cgt gcc aac gcc atc gag aaa tgg gtg gca gtg gcg     3389
 Asp Val Ser Ser Arg Ala Asn Ala Ile Glu Lys Trp Val Ala Val Ala
                1070                1075                1080

 gac atc tgc cga tgc ctg cac aac tac aac ggc gtg ctg gag atc acc     3437
 Asp Ile Cys Arg Cys Leu His Asn Tyr Asn Gly Val Leu Glu Ile Thr
            1085                1090                1095

 tcg gcc tta aac aga agt gcc atc tac agg ctg aag aaa acc tgg gcc     3485
 Ser Ala Leu Asn Arg Ser Ala Ile Tyr Arg Leu Lys Lys Thr Trp Ala
        1100                1105                1110

 aag gtc tct aag cag aca aaa gct cta atg gac aaa ctt caa aag act     3533
 Lys Val Ser Lys Gln Thr Lys Ala Leu Met Asp Lys Leu Gln Lys Thr
    1115                1120                1125

 gtt tcc tct gaa gga aga ttt aaa aat ctt aga gaa acc ctt aaa aat     3581
 Val Ser Ser Glu Gly Arg Phe Lys Asn Leu Arg Glu Thr Leu Lys Asn
1130                1135                1140                1145

 tgt aac cct cct gca gtt cct tat ctt ggg atg tac ttg aca gac ctg     3629
 Cys Asn Pro Pro Ala Val Pro Tyr Leu Gly Met Tyr Leu Thr Asp Leu
                1150                1155                1160

 gca ttt att gaa gaa gga aca cca aac ttt act gag gaa ggc ctt gtc     3677
 Ala Phe Ile Glu Glu Gly Thr Pro Asn Phe Thr Glu Glu Gly Leu Val
            1165                1170                1175

 aat ttc tcc aaa atg aga atg ata tca cac atc atc aga gag ata cgc     3725
 Asn Phe Ser Lys Met Arg Met Ile Ser His Ile Ile Arg Glu Ile Arg
        1180                1185                1190

 cag ttc cag cag act tcc tac aga ata gat cat cag cca aag gtc gca     3773
 Gln Phe Gln Gln Thr Ser Tyr Arg Ile Asp His Gln Pro Lys Val Ala
    1195                1200                1205

 cag tac ttg ctt gac aaa gac ctt atc ata gat gaa gat acg cta tat     3821
 Gln Tyr Leu Leu Asp Lys Asp Leu Ile Ile Asp Glu Asp Thr Leu Tyr
1210                1215                1220                1225

 gag ctg tca ctc aaa att gaa cct cga ctc cct gct                     3857
 Glu Leu Ser Leu Lys Ile Glu Pro Arg Leu Pro Ala 
                1230                1235





      <210> 314
      <211> 6267
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(4994)

      <400> 314
 gtgaatcggc cgagggaaga ttctgccgat tccacgtaga cctgaaccat ttctcagtga     60

 ggcaa    atg ctc gcc acc acg tcc ccg gcg ctg atg aat ggc agt ggg     107
          Met Leu Ala Thr Thr Ser Pro Ala Leu Met Asn Gly Ser Gly
            1               5                  10

 cag agc cca tct gtc ctc aag ggc atc ctt cat gaa gcc gcc atg cag      155
 Gln Ser Pro Ser Val Leu Lys Gly Ile Leu His Glu Ala Ala Met Gln
  15                  20                  25                  30

 tat ccg aag cag gga ata ttt tca gtc act tgt cct cat cca gat ata      203
 Tyr Pro Lys Gln Gly Ile Phe Ser Val Thr Cys Pro His Pro Asp Ile
                  35                  40                  45

 ttt ctt gtg gcc aga att gaa aaa gtc ctt cag ggg agc atc aca cat      251
 Phe Leu Val Ala Arg Ile Glu Lys Val Leu Gln Gly Ser Ile Thr His
              50                  55                  60

 tgc gct gag cca tat atg aaa agt tca gac tct tct aag gtg gcc cag      299
 Cys Ala Glu Pro Tyr Met Lys Ser Ser Asp Ser Ser Lys Val Ala Gln
          65                  70                  75

 aag gtg ctg aag aat gcc aag cag gca tgc caa aga cta gga cag tat      347
 Lys Val Leu Lys Asn Ala Lys Gln Ala Cys Gln Arg Leu Gly Gln Tyr
      80                  85                  90

 aga atg cca ttt gct tgg gca gca agg aca ttg ttt aag gat gca tct      395
 Arg Met Pro Phe Ala Trp Ala Ala Arg Thr Leu Phe Lys Asp Ala Ser
  95                 100                 105                 110

 gga aat ctt gac aaa aat gcc aga ttt tct gcc atc tac agg caa gac      443
 Gly Asn Leu Asp Lys Asn Ala Arg Phe Ser Ala Ile Tyr Arg Gln Asp
                 115                 120                 125

 agc aat aag cta tcc aat gat gac atg ctc aag tta ctt gca gac ttt      491
 Ser Asn Lys Leu Ser Asn Asp Asp Met Leu Lys Leu Leu Ala Asp Phe
             130                 135                 140

 cgg aaa cct gag aag atg gct aag ctc cca gtg att tta ggc aat cta      539
 Arg Lys Pro Glu Lys Met Ala Lys Leu Pro Val Ile Leu Gly Asn Leu
         145                 150                 155

 gac att aca att gat aat gtt tcc tca gac ttc cct aat tat gtt aat      587
 Asp Ile Thr Ile Asp Asn Val Ser Ser Asp Phe Pro Asn Tyr Val Asn
     160                 165                 170

 tca tca tac att ccc aca aaa caa ttt gaa acc tgc agt aaa act ccc      635
 Ser Ser Tyr Ile Pro Thr Lys Gln Phe Glu Thr Cys Ser Lys Thr Pro
 175                 180                 185                 190

 atc acg ttt gaa gtg gag gaa ttt gtg ccc tgc ata cca aaa cac act      683
 Ile Thr Phe Glu Val Glu Glu Phe Val Pro Cys Ile Pro Lys His Thr
                 195                 200                 205

 cag cct tac acc atc tac acc aat cac ctt tac gtt tat cct aag tac      731
 Gln Pro Tyr Thr Ile Tyr Thr Asn His Leu Tyr Val Tyr Pro Lys Tyr
             210                 215                 220

 ttg aaa tac gac agt cag aag tct ttt gcc aag gct aga aat att gcg      779
 Leu Lys Tyr Asp Ser Gln Lys Ser Phe Ala Lys Ala Arg Asn Ile Ala
         225                 230                 235

 att tgc att gaa ttc aaa gat tca gat gag gaa gac tct cag ccc ctt      827
 Ile Cys Ile Glu Phe Lys Asp Ser Asp Glu Glu Asp Ser Gln Pro Leu
     240                 245                 250

 aag tgc att tat ggc aga cct ggt ggg cca gtt ttc aca aga agc gcc      875
 Lys Cys Ile Tyr Gly Arg Pro Gly Gly Pro Val Phe Thr Arg Ser Ala
 255                 260                 265                 270

 ttt gct gca gtt tta cac cat cac caa aac cca gaa ttt tat gat gag      923
 Phe Ala Ala Val Leu His His His Gln Asn Pro Glu Phe Tyr Asp Glu
                 275                 280                 285

 att aaa ata gag ttg ccc act cag ctg cat gaa aag cac cac ctg ttg      971
 Ile Lys Ile Glu Leu Pro Thr Gln Leu His Glu Lys His His Leu Leu
             290                 295                 300

 ctc aca ttc ttc cat gtc agc tgt gac aac tca agt aaa gga agc acg     1019
 Leu Thr Phe Phe His Val Ser Cys Asp Asn Ser Ser Lys Gly Ser Thr
         305                 310                 315

 aag aag agg gat gtc gtt gaa acc caa gtt ggc tac tcc tgg ctt ccc     1067
 Lys Lys Arg Asp Val Val Glu Thr Gln Val Gly Tyr Ser Trp Leu Pro
     320                 325                 330

 ctc ctg aaa gac gga agg gtg gtg aca agc gag cag cac atc ccg gtc     1115
 Leu Leu Lys Asp Gly Arg Val Val Thr Ser Glu Gln His Ile Pro Val
 335                 340                 345                 350

 tcg gcg aac ctt cct tcg ggc tat ctt ggc tac cag gag ctt ggg atg     1163
 Ser Ala Asn Leu Pro Ser Gly Tyr Leu Gly Tyr Gln Glu Leu Gly Met
                 355                 360                 365

 ggc agg cat tat ggt ccg gaa att aaa tgg gta gat gga ggc aag cca     1211
 Gly Arg His Tyr Gly Pro Glu Ile Lys Trp Val Asp Gly Gly Lys Pro
             370                 375                 380

 ctg ctg aaa att tcc act cat ctg gtt tct aca gtg tat act cag gat     1259
 Leu Leu Lys Ile Ser Thr His Leu Val Ser Thr Val Tyr Thr Gln Asp
         385                 390                 395

 cag cat tta cat aat ttt ttc cag tac tgt cag aaa acc gaa tct gga     1307
 Gln His Leu His Asn Phe Phe Gln Tyr Cys Gln Lys Thr Glu Ser Gly
     400                 405                 410

 gcc caa gcc tta gga aac gaa ctt gta aag tac ctt aag agt ctg cat     1355
 Ala Gln Ala Leu Gly Asn Glu Leu Val Lys Tyr Leu Lys Ser Leu His
 415                 420                 425                 430

 gcg atg gaa ggc cac gtg atg atc gcc ttc ttg ccc act atc cta aac     1403
 Ala Met Glu Gly His Val Met Ile Ala Phe Leu Pro Thr Ile Leu Asn
                 435                 440                 445

 cag ctg ttc cga gtc ctc acc aga gcc aca cag gaa gaa gtc gcg gtt     1451
 Gln Leu Phe Arg Val Leu Thr Arg Ala Thr Gln Glu Glu Val Ala Val
             450                 455                 460

 aac gtg act cgg gtc att att cat gtg gtt gcc cag tgc cat gag gaa     1499
 Asn Val Thr Arg Val Ile Ile His Val Val Ala Gln Cys His Glu Glu
         465                 470                 475

 gga ttg gag agc cac ttg agg tca tat gtt aag tac gcg tat aag gct     1547
 Gly Leu Glu Ser His Leu Arg Ser Tyr Val Lys Tyr Ala Tyr Lys Ala
     480                 485                 490

 gag cca tat gtt gcc tct gaa tac aag aca gtg cat gaa gaa ctg acc     1595
 Glu Pro Tyr Val Ala Ser Glu Tyr Lys Thr Val His Glu Glu Leu Thr
 495                 500                 505                 510

 aaa tcc atg acc acg att ctc aag cct tct gcc gat ttc ctc acc agc     1643
 Lys Ser Met Thr Thr Ile Leu Lys Pro Ser Ala Asp Phe Leu Thr Ser
                 515                 520                 525

 aac aaa cta ctg aag tac tca tgg ttt ttc ttt gat gta ctg atc aaa     1691
 Asn Lys Leu Leu Lys Tyr Ser Trp Phe Phe Phe Asp Val Leu Ile Lys
             530                 535                 540

 tct atg gct cag cat ttg ata gag aac tcc aaa gtt aag ttg ctg cga     1739
 Ser Met Ala Gln His Leu Ile Glu Asn Ser Lys Val Lys Leu Leu Arg
         545                 550                 555

 aac cag aga ttt cct gca tcc tat cat cat gca gtg gaa acc gtt gta     1787
 Asn Gln Arg Phe Pro Ala Ser Tyr His His Ala Val Glu Thr Val Val
     560                 565                 570

 aat atg ctg atg cca cac atc act cag aag ttt cga gat aat cca gag     1835
 Asn Met Leu Met Pro His Ile Thr Gln Lys Phe Arg Asp Asn Pro Glu
 575                 580                 585                 590

 gca tct aag aac gcg aat cat agc ctt gct gtc ttc atc aag aga tgt     1883
 Ala Ser Lys Asn Ala Asn His Ser Leu Ala Val Phe Ile Lys Arg Cys
                 595                 600                 605

 ttc acc ttc atg gac agg ggc ttt gtc ttc aag cag atc aac aac tac     1931
 Phe Thr Phe Met Asp Arg Gly Phe Val Phe Lys Gln Ile Asn Asn Tyr
             610                 615                 620

 att agc tgt ttt gct cct gga gac cca aag acc ctc ttt gaa tac aag     1979
 Ile Ser Cys Phe Ala Pro Gly Asp Pro Lys Thr Leu Phe Glu Tyr Lys
         625                 630                 635

 ttt gaa ttt ctc cgt gta gtg tgc aac cat gaa cat tat att ccg ttg     2027
 Phe Glu Phe Leu Arg Val Val Cys Asn His Glu His Tyr Ile Pro Leu
     640                 645                 650

 aac tta cca atg cca ttt gga aaa ggc agg att caa aga tac caa gac     2075
 Asn Leu Pro Met Pro Phe Gly Lys Gly Arg Ile Gln Arg Tyr Gln Asp
 655                 660                 665                 670

 ctc cag ctt gac tac tca tta aca gat gag ttc tgc aga aac cac ttc     2123
 Leu Gln Leu Asp Tyr Ser Leu Thr Asp Glu Phe Cys Arg Asn His Phe
                 675                 680                 685

 ttg gtg gga ctg tta ctg agg gag gtg ggg aca gcc ctc cag gag ttc     2171
 Leu Val Gly Leu Leu Leu Arg Glu Val Gly Thr Ala Leu Gln Glu Phe
             690                 695                 700

 cgg gag gtc cgt ctg atc gcc atc agt gtg ctc aag aac ctg ctg ata     2219
 Arg Glu Val Arg Leu Ile Ala Ile Ser Val Leu Lys Asn Leu Leu Ile
         705                 710                 715

 aag cat tct ttt gat gac aga tat gct tca agg agc cat cag gca agg     2267
 Lys His Ser Phe Asp Asp Arg Tyr Ala Ser Arg Ser His Gln Ala Arg
     720                 725                 730

 ata gcc acc ctc tac ctg cct ctg ttt ggt ctg ctg att gaa aac gtc     2315
 Ile Ala Thr Leu Tyr Leu Pro Leu Phe Gly Leu Leu Ile Glu Asn Val
 735                 740                 745                 750

 cag cgg atc aat gtg agg gat gtg tca ccc ttc cct gtg aac gcg ggc     2363
 Gln Arg Ile Asn Val Arg Asp Val Ser Pro Phe Pro Val Asn Ala Gly
                 755                 760                 765

 atg act gtg aag gat gaa tcc ctg gct cta cca gct gtg aat ccg ctg     2411
 Met Thr Val Lys Asp Glu Ser Leu Ala Leu Pro Ala Val Asn Pro Leu
             770                 775                 780

 gtg acg ccg cag aag gga agc acc ctg gac aac agc ctg cac aag gac     2459
 Val Thr Pro Gln Lys Gly Ser Thr Leu Asp Asn Ser Leu His Lys Asp
         785                 790                 795

 ctg ctg ggc gcc atc tcc ggc att gct tct cca tat aca acc tca act     2507
 Leu Leu Gly Ala Ile Ser Gly Ile Ala Ser Pro Tyr Thr Thr Ser Thr
     800                 805                 810

 cca aac atc aac agt gtg aga aat gct gat tcg aga gga tct ctc ata     2555
 Pro Asn Ile Asn Ser Val Arg Asn Ala Asp Ser Arg Gly Ser Leu Ile
 815                 820                 825                 830

 agc aca gat tcg ggt aac agc ctt cca gaa agg aat agt gag aag agc     2603
 Ser Thr Asp Ser Gly Asn Ser Leu Pro Glu Arg Asn Ser Glu Lys Ser
                 835                 840                 845

 aat tcc ctg gat aag cac caa caa agt agc aca ttg gga aat tcc gtg     2651
 Asn Ser Leu Asp Lys His Gln Gln Ser Ser Thr Leu Gly Asn Ser Val
             850                 855                 860

 gtt cgc tgt gat aaa ctt gac cag tct gag att aag agc cta ctg atg     2699
 Val Arg Cys Asp Lys Leu Asp Gln Ser Glu Ile Lys Ser Leu Leu Met
         865                 870                 875

 tgt ttc ctc tac atc tta aag agc atg tct gat gat gct ttg ttt aca     2747
 Cys Phe Leu Tyr Ile Leu Lys Ser Met Ser Asp Asp Ala Leu Phe Thr
     880                 885                 890

 tat tgg aac aag gct tca aca tct gaa ctt atg gat ttt ttt aca ata     2795
 Tyr Trp Asn Lys Ala Ser Thr Ser Glu Leu Met Asp Phe Phe Thr Ile
 895                 900                 905                 910

 tct gaa gtc tgc ctg cac cag ttc cag tac atg ggg aag cga tac ata     2843
 Ser Glu Val Cys Leu His Gln Phe Gln Tyr Met Gly Lys Arg Tyr Ile
                 915                 920                 925

 gcc aga aca gga atg atg cat gcc aga ttg cag cag ctg ggc agc ctg     2891
 Ala Arg Thr Gly Met Met His Ala Arg Leu Gln Gln Leu Gly Ser Leu
             930                 935                 940

 gat aac tct ctc act ttt aac cac agc tat ggc cac tcg gac gca gat     2939
 Asp Asn Ser Leu Thr Phe Asn His Ser Tyr Gly His Ser Asp Ala Asp
         945                 950                 955

 gtt ctg cac cag tca tta ctt gaa gcc aac att gct act gag gtt tgc     2987
 Val Leu His Gln Ser Leu Leu Glu Ala Asn Ile Ala Thr Glu Val Cys
     960                 965                 970

 ctg aca gct ctg gac acg ctt tct cta ttt aca ttg gcg ttt aag aac     3035
 Leu Thr Ala Leu Asp Thr Leu Ser Leu Phe Thr Leu Ala Phe Lys Asn
 975                 980                 985                 990

 cag ctc ctg gcc gac cat gga cat aat cct ctc atg aaa aaa gtt ttt     3083
 Gln Leu Leu Ala Asp His Gly His Asn Pro Leu Met Lys Lys Val Phe
                 995                1000                1005

 gat gtc tac ctg tgt ttt ctt caa aaa cat cag tct gaa acg gct tta     3131
 Asp Val Tyr Leu Cys Phe Leu Gln Lys His Gln Ser Glu Thr Ala Leu
            1010                1015                1020

 aaa aat gtc ttc act gcc tta agg tcc tta att tat aag ttt ccc tca     3179
 Lys Asn Val Phe Thr Ala Leu Arg Ser Leu Ile Tyr Lys Phe Pro Ser
        1025                1030                1035

 aca ttc tat gaa ggg aga gcg gac atg tgt gcg gct ctg tgt tac gag     3227
 Thr Phe Tyr Glu Gly Arg Ala Asp Met Cys Ala Ala Leu Cys Tyr Glu
    1040                1045                1050

 att ctc aag tgc tgt aac tcc aag ctg agc tcc atc agg acg gag gcc     3275
 Ile Leu Lys Cys Cys Asn Ser Lys Leu Ser Ser Ile Arg Thr Glu Ala
1055                1060                1065                1070

 tcc cag ctg ctc tac ttc ctg atg agg aac aac ttt gat tac act gga     3323
 Ser Gln Leu Leu Tyr Phe Leu Met Arg Asn Asn Phe Asp Tyr Thr Gly
                1075                1080                1085

 aag aag tcc ttt gtc cgg aca cat ttg caa gtc atc ata tct gtc agc     3371
 Lys Lys Ser Phe Val Arg Thr His Leu Gln Val Ile Ile Ser Val Ser
            1090                1095                1100

 cag ctg ata gca gac gtt gtt ggc att ggg gga acc aga ttc cag cag     3419
 Gln Leu Ile Ala Asp Val Val Gly Ile Gly Gly Thr Arg Phe Gln Gln
        1105                1110                1115

 tcc ctg tcc atc atc aac aac tgt gcc aac agt gac cgg ctt att aag     3467
 Ser Leu Ser Ile Ile Asn Asn Cys Ala Asn Ser Asp Arg Leu Ile Lys
    1120                1125                1130

 cac acc agc ttc tcc tct gat gtg aag gac tta acc aaa agg ata cgc     3515
 His Thr Ser Phe Ser Ser Asp Val Lys Asp Leu Thr Lys Arg Ile Arg
1135                1140                1145                1150

 acg gtg cta atg gcc acc gcc cag atg aag gag cat gag aac gac cca     3563
 Thr Val Leu Met Ala Thr Ala Gln Met Lys Glu His Glu Asn Asp Pro
                1155                1160                1165

 gag atg ctg gtg gac ctc cag tac agc ctg gcc aaa tcc tat gcc agc     3611
 Glu Met Leu Val Asp Leu Gln Tyr Ser Leu Ala Lys Ser Tyr Ala Ser
            1170                1175                1180

 acg ccc gag ctc agg aag acg tgg ctc gac agc atg gcc agg atc cat     3659
 Thr Pro Glu Leu Arg Lys Thr Trp Leu Asp Ser Met Ala Arg Ile His
        1185                1190                1195

 gtc aaa aat ggc gat ctc tca gag gca gca atg tgc tat gtc cac gta     3707
 Val Lys Asn Gly Asp Leu Ser Glu Ala Ala Met Cys Tyr Val His Val
    1200                1205                1210

 aca gcc cta gtg gca gaa tat ctc aca cgg aaa gaa gca gtc cag tgg     3755
 Thr Ala Leu Val Ala Glu Tyr Leu Thr Arg Lys Glu Ala Val Gln Trp
1215                1220                1225                1230

 gag ccg ccc ctt ctc ccc cac agc cat agc gcc tgc ctg agg agg agc     3803
 Glu Pro Pro Leu Leu Pro His Ser His Ser Ala Cys Leu Arg Arg Ser
                1235                1240                1245

 cgg gga ggc gtg ttt aga caa gga tgc acc gcc ttc agg gtc att acc     3851
 Arg Gly Gly Val Phe Arg Gln Gly Cys Thr Ala Phe Arg Val Ile Thr
            1250                1255                1260

 cca aac atc gac gag gag gcc tcc atg atg gaa gac gtg ggg atg cag     3899
 Pro Asn Ile Asp Glu Glu Ala Ser Met Met Glu Asp Val Gly Met Gln
        1265                1270                1275

 gat gtc cat ttc aac gag gat gtg ctg atg gag ctc ctt gag cag tgc     3947
 Asp Val His Phe Asn Glu Asp Val Leu Met Glu Leu Leu Glu Gln Cys
    1280                1285                1290

 gca gat gga ctc tgg aaa gcc gag cgc tac gag ctc att gcc gac atc     3995
 Ala Asp Gly Leu Trp Lys Ala Glu Arg Tyr Glu Leu Ile Ala Asp Ile
1295                1300                1305                1310

 tac aaa ctt atc atc ccc att tat gag aag cgg agg gat ttt gag agg     4043
 Tyr Lys Leu Ile Ile Pro Ile Tyr Glu Lys Arg Arg Asp Phe Glu Arg
                1315                1320                1325

 ctg gcc cat ctg tat gac acg ctg cac cgg gcc tac agc aaa gtg acc     4091
 Leu Ala His Leu Tyr Asp Thr Leu His Arg Ala Tyr Ser Lys Val Thr
            1330                1335                1340

 gag gtc atg cac tcg ggc cgc agg ctt ctg ggg acc tac ttc cgg gta     4139
 Glu Val Met His Ser Gly Arg Arg Leu Leu Gly Thr Tyr Phe Arg Val
        1345                1350                1355

 gcc ttc ttc ggg cag gca gcg caa tac cag ttt aca gac agt gaa aca     4187
 Ala Phe Phe Gly Gln Ala Ala Gln Tyr Gln Phe Thr Asp Ser Glu Thr
    1360                1365                1370

 gat gtg gag gga ttc ttt gaa gat gaa gat gga aag gag tat att tac     4235
 Asp Val Glu Gly Phe Phe Glu Asp Glu Asp Gly Lys Glu Tyr Ile Tyr
1375                1380                1385                1390

 aag gaa ccc aaa ctc aca ccg ctg tcg gaa att tct cag aga ctc ctt     4283
 Lys Glu Pro Lys Leu Thr Pro Leu Ser Glu Ile Ser Gln Arg Leu Leu
                1395                1400                1405

 aaa ctg tac tcg gat aaa ttt ggt tct gaa aat gtc aaa atg ata cag     4331
 Lys Leu Tyr Ser Asp Lys Phe Gly Ser Glu Asn Val Lys Met Ile Gln
            1410                1415                1420

 gat tct ggc aag gtc aac cct aag gat ctg gat tct aag tat gcc tac     4379
 Asp Ser Gly Lys Val Asn Pro Lys Asp Leu Asp Ser Lys Tyr Ala Tyr
        1425                1430                1435

 atc cag gtg act cac gtc atc ccc ttc ttt gac gaa aaa gag ttg caa     4427
 Ile Gln Val Thr His Val Ile Pro Phe Phe Asp Glu Lys Glu Leu Gln
    1440                1445                1450

 gaa agg aaa aca gag ttt gag aga tcc cac aac atc cgc cgc ttc atg     4475
 Glu Arg Lys Thr Glu Phe Glu Arg Ser His Asn Ile Arg Arg Phe Met
1455                1460                1465                1470

 ttt gag atg cca ttt acg cag acc ggg aag agg cag ggc ggg gtg gaa     4523
 Phe Glu Met Pro Phe Thr Gln Thr Gly Lys Arg Gln Gly Gly Val Glu
                1475                1480                1485

 gag cag tgc aaa cgg cgc acc atc ctg aca gcc ata cac tgc ttc cct     4571
 Glu Gln Cys Lys Arg Arg Thr Ile Leu Thr Ala Ile His Cys Phe Pro
            1490                1495                1500

 tat gtg aag aag cgc atc cct gtc atg tac cag cac cac act gac ctg     4619
 Tyr Val Lys Lys Arg Ile Pro Val Met Tyr Gln His His Thr Asp Leu
        1505                1510                1515

 aac ccc atc gag gtg gcc att gac gag atg agt aag aag gtg gcg gag     4667
 Asn Pro Ile Glu Val Ala Ile Asp Glu Met Ser Lys Lys Val Ala Glu
    1520                1525                1530

 ctc cgg cag ctg tgc tcc tcg gcc gag gtg gac atg atc aaa ctg cag     4715
 Leu Arg Gln Leu Cys Ser Ser Ala Glu Val Asp Met Ile Lys Leu Gln
1535                1540                1545                1550

 ctc aaa ctc cag ggc agc gtg agt gtt cag gtc aat gct ggc cca cta     4763
 Leu Lys Leu Gln Gly Ser Val Ser Val Gln Val Asn Ala Gly Pro Leu
                1555                1560                1565

 gca tat gcg cga gct ttc tta gat gat aca aac aca aag cga tat cct     4811
 Ala Tyr Ala Arg Ala Phe Leu Asp Asp Thr Asn Thr Lys Arg Tyr Pro
            1570                1575                1580

 gac aat aaa gtg aag ctg ctt aag gaa gtt ttc agg caa ttt gtg gaa     4859
 Asp Asn Lys Val Lys Leu Leu Lys Glu Val Phe Arg Gln Phe Val Glu
        1585                1590                1595

 gct tgc ggt caa gcc tta gcg gta aac gaa cgt ctg att aaa gaa gac     4907
 Ala Cys Gly Gln Ala Leu Ala Val Asn Glu Arg Leu Ile Lys Glu Asp
    1600                1605                1610

 cag ctc gag tat cag gaa gaa atg aaa gcc aac tac agg gaa atg gcg     4955
 Gln Leu Glu Tyr Gln Glu Glu Met Lys Ala Asn Tyr Arg Glu Met Ala
1615                1620                1625                1630

 aag gag ctt tct gaa atc atg cat gag cag ctg gga tga tctgccccct      5004
 Lys Glu Leu Ser Glu Ile Met His Glu Gln Leu Gly 
                1635                1640

 ggaggagaag acgagcgtct taccgaattc ccttcacatc ttcaacgcca tcagtgggac   5064

 tccaacaagc acaatggttc acgggatgac cagctcgtct tcggtcgtgt gattacatct   5124

 catggcccgt gtgtggggac ttgctttgtc atttgcaaac tcaggatgct ttccaaagcc   5184

 aatcactggg gagaccgagc acagggagga ccaaggggaa ggggagagaa aggaaataaa   5244

 gaacaacgtt atttcttaac agactttcta taggagttgt aagaaggtgc acatattttt   5304

 ttaaatctca ctggcaatat tcaaagtttt cattgtgtct taacaaaggt gtggtagaca   5364

 ctcttgagct ggacttagat tttattcttc cttgcagagt agtgttagaa tagatggcct   5424

 acagaaaaaa aaggttctgg gatctacatg gcagggaggg ctgcactgac attgatgcct   5484

 gggggacctt ttgcctcgag gctgagctgg aaaatcttga aaatattttt tttttcctgt   5544

 ggcacattca ggttgaatac aagaactatt tttgtgacta gtttttgatg acctaaggga   5604

 actgaccatt gtaatttttg taccagtgaa ccaggagatt tagtgctttt atattcattt   5664

 ccttgcattt aagaaaatat gaaagcttaa ggaattatgt gagcttaaaa ctagtcaagc   5724

 agtttagaac caaaggccta tattaataac cgcaactatg ctgaaaagta caaagtagta   5784

 cagtatattg ttatgtacat atcattgtta atacagtcct ggcattctgt acatatatgt   5844

 attacatttc tacattttta atactcacat gggcttatgc attaagttta attgtgataa   5904

 atttgtgctg ttccagtata tgcaatacac tttaatgttt tattcttgta cataaaaatg   5964

 tgcaatatgg agatgtatac agtctttact atattaggtt tataaacagt tttaagaatt   6024

 tcatcctttt gccaaaatgg tggagtatgt aattggtaaa tcataaatcc tgtggtgaat   6084

 ggtggtgtac tttaaagctg tcaccatgtt atattttctt ttaagacatt aatttagtaa   6144

 ttttatattt gggaaaataa aggtttttaa ttttatttaa ctggaatcac tgccctgctg   6204

 taattaaaca ttctgtacca catctgtatt aaaaagacat tgctgaccat taaaaaaaaa   6264

 aaa                                                                 6267




      <210> 315
      <211> 1861
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (186)..(1058)

      <400> 315
 agactgcggg cctgcgggga agggcgaagc ggggcgggac cgggggcggg agcagcgcgg     60

 ggcgggaccc tacccgcggc ccacgcggag ccaggaggcg cggactacag ctcccggcct    120

 gccccgcgtg cggtccccgc ccgcccccag cgcccgggag gaggatgcag acgccgcggc    180

 cggcg    atg agg atg gag gcc ggg gag gca gcg ccg ccg gcg ggg gcg     227
          Met Arg Met Glu Ala Gly Glu Ala Ala Pro Pro Ala Gly Ala
            1               5                  10

 ggc ggc cgc gcc gca ggc ggc tgg ggc aag tgg gtg cgg ctc aac gtg      275
 Gly Gly Arg Ala Ala Gly Gly Trp Gly Lys Trp Val Arg Leu Asn Val
  15                  20                  25                  30

 ggg ggc acg gtg ttc ctg acc acc cgg cag acg ctg tgc cgc gag cag      323
 Gly Gly Thr Val Phe Leu Thr Thr Arg Gln Thr Leu Cys Arg Glu Gln
                  35                  40                  45

 aag tcc ttc ctc agc cgc ctg tgc cag ggg gaa gag ctg cag tcg gac      371
 Lys Ser Phe Leu Ser Arg Leu Cys Gln Gly Glu Glu Leu Gln Ser Asp
              50                  55                  60

 cgg gat gag acc ggg gcc tac ctc att gac cgt gac ccc acc tac ttc      419
 Arg Asp Glu Thr Gly Ala Tyr Leu Ile Asp Arg Asp Pro Thr Tyr Phe
          65                  70                  75

 ggg ccc atc ctg aac ttc ctc cgg cat ggc aag ctg gtg ctg gac aag      467
 Gly Pro Ile Leu Asn Phe Leu Arg His Gly Lys Leu Val Leu Asp Lys
      80                  85                  90

 gac atg gct gag gag ggg gtc ctg gag gaa gcc gag ttc tac aac atc      515
 Asp Met Ala Glu Glu Gly Val Leu Glu Glu Ala Glu Phe Tyr Asn Ile
  95                 100                 105                 110

 ggc ccg ctg atc cgc atc atc aaa gac cgg atg gaa gag aag gac tac      563
 Gly Pro Leu Ile Arg Ile Ile Lys Asp Arg Met Glu Glu Lys Asp Tyr
                 115                 120                 125

 acg gtc acc cag gtc cca ccc aag cat gtg tac cgc gtg ctg cag tgc      611
 Thr Val Thr Gln Val Pro Pro Lys His Val Tyr Arg Val Leu Gln Cys
             130                 135                 140

 cag gag gag gag ctc acg caa atg gtc tcc acc atg tct gat ggc tgg      659
 Gln Glu Glu Glu Leu Thr Gln Met Val Ser Thr Met Ser Asp Gly Trp
         145                 150                 155

 cgc ttc gag cag ctg gtg aac atc ggc tcc tcc tac aac tac ggc agc      707
 Arg Phe Glu Gln Leu Val Asn Ile Gly Ser Ser Tyr Asn Tyr Gly Ser
     160                 165                 170

 gag gac cag gca gag ttc ctg tgt gtg gtg tcc aag gag ctc cac agc      755
 Glu Asp Gln Ala Glu Phe Leu Cys Val Val Ser Lys Glu Leu His Ser
 175                 180                 185                 190

 acc cca aac ggg ctg agc tca gag tcc agc cgc aaa acc aag agc acg      803
 Thr Pro Asn Gly Leu Ser Ser Glu Ser Ser Arg Lys Thr Lys Ser Thr
                 195                 200                 205

 gag gag cag ctg gag gag cag cag cag cag gag gag gag gtg gag gag      851
 Glu Glu Gln Leu Glu Glu Gln Gln Gln Gln Glu Glu Glu Val Glu Glu
             210                 215                 220

 gtg gag gtg gaa cag gtg cag gtg gag gca gat gca cag gag aaa ggt      899
 Val Glu Val Glu Gln Val Gln Val Glu Ala Asp Ala Gln Glu Lys Gly
         225                 230                 235

 tcc cgt ccg cac cct ctc aga cct gag gct gag ctt gca gtg agg gct      947
 Ser Arg Pro His Pro Leu Arg Pro Glu Ala Glu Leu Ala Val Arg Ala
     240                 245                 250

 tct cct cgg ccc ctc gcc cgc ccc cag agc tgc cat ccc tgc tgt tac      995
 Ser Pro Arg Pro Leu Ala Arg Pro Gln Ser Cys His Pro Cys Cys Tyr
 255                 260                 265                 270

 aag cca gag gca ccc gga tgt gag gcc cca gat cac ctc cag gga ctt     1043
 Lys Pro Glu Ala Pro Gly Cys Glu Ala Pro Asp His Leu Gln Gly Leu
                 275                 280                 285

 ggg gtt ccc atc tga aatcctttat ttttgtacca tggggtgggc cccgggcctg     1098
 Gly Val Pro Ile 
             290

 agaaggaaga agcaccctct ccccggcctc ctctgtctgc acccgtgggg ctgtgactta   1158

 ctcctgcctc caggggcggg gcggggcccc cctgggacct cttaaggccc aaggtgggcc   1218

 ccaggacctc tgggcagagt ggactgctca tggcagatgt gtggcaatgt ctggctgtgt   1278

 ctctccggca cctgcgtccc ctctcccggg ctcccctgct gcatggtgga tgtgctcctt   1338

 cctggcccgg tcacattgcc tccttgagcc ttagtccagg gggtcactcc tcccacccca   1398

 cctacctcac agggttgttg tgagggtgca cagaggagca aagtccctga aggccctcag   1458

 gcagtatata ggggccgccc accttcagct gccctgggat gggaaggacc cagcccgacc   1518

 cctgggcata acactgtgtt tgcaaatgga gattcaggta ttggggatgc aggttgtggg   1578

 gagctggcct ggcagagtag gggtagttgg cttggccttc tctttggtga tcccaccccc   1638

 agccatttgc attgctggcc cagcgcctgg cctggggggc ggggagaggc agcagaaggg   1698

 gctgggcagg ggcggtggag gactcaggaa ctgcccgggg agagtgggta tggcggctga   1758

 gccaggggcc ctcctgtgtt tgacttcccg ggatgggtcc ttgcttctca gctgtgtccg   1818

 accccaccat gtaataaaac ccaaaggaac aaaaaaaaaa aaa                     1861




      <210> 316
      <211> 2946
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (201)..(2372)

      <400> 316
 gggcatgcgg taccgctccg gaattaccgg gtcgacgatc tcgagtggct agagctgaaa     60

 ggcgaccgct ggtgtcaaac atcttagctc aaatatctgg gaacgattgc gcgctgagga    120

 agaccctttg ggacttgtag ctccactccg gggaacggac tcgccgggac tgacagttgc    180

 cggaagtgag gctgcgggga    atg gcc gcc gct gcg acc atg gcg gct gcg     230
                          Met Ala Ala Ala Ala Thr Met Ala Ala Ala
                            1               5                  10

 gcc cgg gaa ctg gtg ttg cgg gct ggg acc tca gat atg gag gag gaa      278
 Ala Arg Glu Leu Val Leu Arg Ala Gly Thr Ser Asp Met Glu Glu Glu
                  15                  20                  25

 gag ggc ccg ctg gcg ggt ggt cct ggg ctc cag gaa cca ctg caa ctt      326
 Glu Gly Pro Leu Ala Gly Gly Pro Gly Leu Gln Glu Pro Leu Gln Leu
              30                  35                  40

 ggg gag ttg gat atc act tct gat gaa ttc atc ctg gat gaa gtg gat      374
 Gly Glu Leu Asp Ile Thr Ser Asp Glu Phe Ile Leu Asp Glu Val Asp
          45                  50                  55

 gtt cac att cag gca aat ctg gag gat gag tta gta aag gaa gct ctt      422
 Val His Ile Gln Ala Asn Leu Glu Asp Glu Leu Val Lys Glu Ala Leu
      60                  65                  70

 aaa acg ggt gta gat ctc cgt cac tat tca aag caa gtt gag ctg gag      470
 Lys Thr Gly Val Asp Leu Arg His Tyr Ser Lys Gln Val Glu Leu Glu
  75                  80                  85                  90

 cta cag cag att gaa cag aaa tcc att cgg gat tat att caa gag agt      518
 Leu Gln Gln Ile Glu Gln Lys Ser Ile Arg Asp Tyr Ile Gln Glu Ser
                  95                 100                 105

 gag aat ata gca tct cta cac aac cag atc aca gcc tgt gat gct gtc      566
 Glu Asn Ile Ala Ser Leu His Asn Gln Ile Thr Ala Cys Asp Ala Val
             110                 115                 120

 ctg gag cga atg gag cag atg ttg gga gct ttt cag agt gac ctc agc      614
 Leu Glu Arg Met Glu Gln Met Leu Gly Ala Phe Gln Ser Asp Leu Ser
         125                 130                 135

 tcc atc agc tct gag atc cgg aca ctg cag gaa cag tca gga gcc atg      662
 Ser Ile Ser Ser Glu Ile Arg Thr Leu Gln Glu Gln Ser Gly Ala Met
     140                 145                 150

 aac att cga ctt cga aat cgc cag gca gtt cgg ggg aaa ctt ggg gag      710
 Asn Ile Arg Leu Arg Asn Arg Gln Ala Val Arg Gly Lys Leu Gly Glu
 155                 160                 165                 170

 ctt gtt gat ggt ctg gtg gtg cct tct gct ctg gtc acg gca att ctg      758
 Leu Val Asp Gly Leu Val Val Pro Ser Ala Leu Val Thr Ala Ile Leu
                 175                 180                 185

 gag gct cca gtg aca gag ccc agg ttc ttg gag cag cta cag gag ctg      806
 Glu Ala Pro Val Thr Glu Pro Arg Phe Leu Glu Gln Leu Gln Glu Leu
             190                 195                 200

 gat gcc aag gca gcc gca gtc aga gag cag gaa gct aga ggc aca gca      854
 Asp Ala Lys Ala Ala Ala Val Arg Glu Gln Glu Ala Arg Gly Thr Ala
         205                 210                 215

 gcc tgc gca gat gtc aga ggc gtg ctc gat cgg ctc cgg gtc aag gca      902
 Ala Cys Ala Asp Val Arg Gly Val Leu Asp Arg Leu Arg Val Lys Ala
     220                 225                 230

 gtg acg aag atc cga gag ttt atc ctc cag aag att tat tcc ttc agg      950
 Val Thr Lys Ile Arg Glu Phe Ile Leu Gln Lys Ile Tyr Ser Phe Arg
 235                 240                 245                 250

 aaa ccc atg acc aac tat cag atc ccc cag acg gcc ctg ctg aag tac      998
 Lys Pro Met Thr Asn Tyr Gln Ile Pro Gln Thr Ala Leu Leu Lys Tyr
                 255                 260                 265

 agg ttc ttc tat cag ttt ctg ctg ggc aat gaa cga gca aca gca aag     1046
 Arg Phe Phe Tyr Gln Phe Leu Leu Gly Asn Glu Arg Ala Thr Ala Lys
             270                 275                 280

 gag atc agg gat gaa tat gtg gag acg ctg agc aag att tac ctg tct     1094
 Glu Ile Arg Asp Glu Tyr Val Glu Thr Leu Ser Lys Ile Tyr Leu Ser
         285                 290                 295

 tac tac cgc tct tac ctg ggg cgg ctc atg aag gtg cag tat gag gaa     1142
 Tyr Tyr Arg Ser Tyr Leu Gly Arg Leu Met Lys Val Gln Tyr Glu Glu
     300                 305                 310

 gtc gct gag aaa gat gat cta atg ggt gtg gaa gat aca gca aag aaa     1190
 Val Ala Glu Lys Asp Asp Leu Met Gly Val Glu Asp Thr Ala Lys Lys
 315                 320                 325                 330

 gga ttc ttc tca aag cca tcg ctc cgc agc agg aac acc att ttc acc     1238
 Gly Phe Phe Ser Lys Pro Ser Leu Arg Ser Arg Asn Thr Ile Phe Thr
                 335                 340                 345

 cta gga acc cgc ggc tct gtc atc tcc ccc act gaa ctt gag gcc ccc     1286
 Leu Gly Thr Arg Gly Ser Val Ile Ser Pro Thr Glu Leu Glu Ala Pro
             350                 355                 360

 atc ctg gtg cct cac aca gcg cag cgc gga gag cag agg tat cca ttt     1334
 Ile Leu Val Pro His Thr Ala Gln Arg Gly Glu Gln Arg Tyr Pro Phe
         365                 370                 375

 gag gcc ctc ttc cgc agc cag cac tac gcc ctc cta gac aat tcc tgc     1382
 Glu Ala Leu Phe Arg Ser Gln His Tyr Ala Leu Leu Asp Asn Ser Cys
     380                 385                 390

 cgc gaa tac ctt ttc atc tgt gaa ttt ttt gtt gtg tct ggc cca gct     1430
 Arg Glu Tyr Leu Phe Ile Cys Glu Phe Phe Val Val Ser Gly Pro Ala
 395                 400                 405                 410

 gca cac gac ctg ttc cat gct gtc atg ggc cgt aca ctc agc atg acc     1478
 Ala His Asp Leu Phe His Ala Val Met Gly Arg Thr Leu Ser Met Thr
                 415                 420                 425

 ctg aaa cac ctg gat tct tat cta gct gac tgc tac gat gcc att gct     1526
 Leu Lys His Leu Asp Ser Tyr Leu Ala Asp Cys Tyr Asp Ala Ile Ala
             430                 435                 440

 gtt ttt ctc tgt atc cac att gtt ctc cgg ttc cgt aac att gca gca     1574
 Val Phe Leu Cys Ile His Ile Val Leu Arg Phe Arg Asn Ile Ala Ala
         445                 450                 455

 aag agg gat gtt cct gcc ctg gac agg tac tgg gaa cag gtg ctt gcc     1622
 Lys Arg Asp Val Pro Ala Leu Asp Arg Tyr Trp Glu Gln Val Leu Ala
     460                 465                 470

 ttg cta tgg cca cgg ttt gaa ctg atc ctg gag atg aat gtt cag agc     1670
 Leu Leu Trp Pro Arg Phe Glu Leu Ile Leu Glu Met Asn Val Gln Ser
 475                 480                 485                 490

 gtc cga agc act gac ccc cag cgc cta ggg ggg ttg gat act cgg ccc     1718
 Val Arg Ser Thr Asp Pro Gln Arg Leu Gly Gly Leu Asp Thr Arg Pro
                 495                 500                 505

 cac tat atc aca cgc cgc tat gca gag ttc tcc tcc gct ctt gtc agt     1766
 His Tyr Ile Thr Arg Arg Tyr Ala Glu Phe Ser Ser Ala Leu Val Ser
             510                 515                 520

 atc aac cag aca att cct aat gaa cgg acc atg caa ttg ctg gga cag     1814
 Ile Asn Gln Thr Ile Pro Asn Glu Arg Thr Met Gln Leu Leu Gly Gln
         525                 530                 535

 ctg cag gtg gag gtg gag aat ttt gtc ctc cga gtg gca gct gag ttc     1862
 Leu Gln Val Glu Val Glu Asn Phe Val Leu Arg Val Ala Ala Glu Phe
     540                 545                 550

 tcc tca agg aag gag cag ctt gtg ttt ctg atc aac aac tat gac atg     1910
 Ser Ser Arg Lys Glu Gln Leu Val Phe Leu Ile Asn Asn Tyr Asp Met
 555                 560                 565                 570

 atg ctg ggt gtg ctg atg gag cgg gct gca gat gac agc aaa gag gtt     1958
 Met Leu Gly Val Leu Met Glu Arg Ala Ala Asp Asp Ser Lys Glu Val
                 575                 580                 585

 gag agc ttc cag cag ctg ctc aat gct cgg aca cag gaa ttc att gaa     2006
 Glu Ser Phe Gln Gln Leu Leu Asn Ala Arg Thr Gln Glu Phe Ile Glu
             590                 595                 600

 gag ttg ctg tct ccc cct ttt ggg ggt tta gtg gca ttt gtg aag gag     2054
 Glu Leu Leu Ser Pro Pro Phe Gly Gly Leu Val Ala Phe Val Lys Glu
         605                 610                 615

 gct gag gct ttg att gag cgt gga cag gct gag cga ctt cga ggg gaa     2102
 Ala Glu Ala Leu Ile Glu Arg Gly Gln Ala Glu Arg Leu Arg Gly Glu
     620                 625                 630

 gaa gcc cgg gta act cag ctg atc cgt ggc ttt ggt agt tcc tgg aaa     2150
 Glu Ala Arg Val Thr Gln Leu Ile Arg Gly Phe Gly Ser Ser Trp Lys
 635                 640                 645                 650

 tca tca gtg gaa tct ctg agt cag gat gta atg cgg agt ttc acc aac     2198
 Ser Ser Val Glu Ser Leu Ser Gln Asp Val Met Arg Ser Phe Thr Asn
                 655                 660                 665

 ttc aga aat ggc acc agt atc att cag gga gcg ctg acc cag ctg atc     2246
 Phe Arg Asn Gly Thr Ser Ile Ile Gln Gly Ala Leu Thr Gln Leu Ile
             670                 675                 680

 cag ctc tat cat cgc ttc cac cgg gtg ctg tcc cag ccg cag ctc cga     2294
 Gln Leu Tyr His Arg Phe His Arg Val Leu Ser Gln Pro Gln Leu Arg
         685                 690                 695

 gcc ctc cct gcc cgg gct gag ctc atc aac att cac cac ctt atg gtg     2342
 Ala Leu Pro Ala Arg Ala Glu Leu Ile Asn Ile His His Leu Met Val
     700                 705                 710

 gag ctc aag aag cat aag ccc aac ttc tga t gtgccagaaa ccgccctgag     2393
 Glu Leu Lys Lys His Lys Pro Asn Phe 
 715                 720

 atctgccggt catctccatg gacttctgca ccccattcca tacccttctt cacctggggt   2453

 accccttcca gttttcccct tgcttcccag gcccttgaca tggcttacct gccttcactc   2513

 ccagcacctt gcccaacagg ataagctgga tccccttggc cttctgaata tcccagtgtc   2573

 ttcaggtttc ccaagaccac ttccctgtgg gcttcccaaa atggccttta tcatttctcc   2633

 agtctgtcac cctcctttcc tgctcccata cacccaaggc ttgtttcttc ccctgtaaaa   2693

 accactgcct caatctctgg ttcactcaac tagtcaccat gtcctgaggc atgaagcctc   2753

 ctcagctctt ggaattgctg gcaaggggtg actgcctctg agtcattgtg tttttcaaag   2813

 tgatttcttt tctgtagctt tttgacctaa gatctcagca atttgaacac taacctctcc   2873

 cctcctggct caagaattac tccgaagtca gtctgcagaa aataaatatt tagtatgaca   2933

 tgaaaaaaaa aaa                                                      2946




      <210> 317
      <211> 5278
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (474)..(4796)

      <400> 317
 agatcttttt tttttttttt ttttaagagg cagatcttgc tcttccgtgg cagtccagca     60

 cctgctgcct cgccctactg cggcccactt tggggccgca gggcttaccc gctcctttcc    120

 gtgcatcata ctttgttttc tgttgaatac tttcctctta gatcaccacc ctgagatggt    180

 agaaaacata aaaatccctg tgtacacgtg gagggagacc ctctgggcct gtggagccca    240

 aatatgaatc taaggcaatg ggtggattct ggattaactg cgtttcacgc tgggaagtga    300

 ctgcggggag tttgggtcct gtgtggtggt gaccgacgat tctgtcctag atcccagtgg    360

 agaacaccaa agcgagcgag gaggaggagg acccgacctt ctgtgaggtg tgcggcagga    420

 gcgaccgtga ggacaggctt ttgctctgcg acggctgcga tgcggggtac cac   atg     476
                                                              Met
                                                                1

 gaa tgc ttg gac ccc cct ctc cag gag gtg ccg gtg gac gag tgg ttc      524
 Glu Cys Leu Asp Pro Pro Leu Gln Glu Val Pro Val Asp Glu Trp Phe
               5                  10                  15

 tgc ccg gaa tgt gct gcg cct ggt gtt gtc ctt gcc gct gat gcg ggt      572
 Cys Pro Glu Cys Ala Ala Pro Gly Val Val Leu Ala Ala Asp Ala Gly
          20                  25                  30

 ccc gtg agt gag gag gag gtc tcc ctg ctc ttg gct gat gtg gtg ccc      620
 Pro Val Ser Glu Glu Glu Val Ser Leu Leu Leu Ala Asp Val Val Pro
      35                  40                  45

 acc acc agc agg ctt cgg cct cga gca ggt agg acc cgg gcg ata gcc      668
 Thr Thr Ser Arg Leu Arg Pro Arg Ala Gly Arg Thr Arg Ala Ile Ala
  50                  55                  60                  65

 agg aca cgg cag agt gag aga gtg aga gca acc gtg aac cgg aac cgg      716
 Arg Thr Arg Gln Ser Glu Arg Val Arg Ala Thr Val Asn Arg Asn Arg
                  70                  75                  80

 atc tcc acg gcc agg agg gtc cag cac aca cca ggg cgc ctc ggg tct      764
 Ile Ser Thr Ala Arg Arg Val Gln His Thr Pro Gly Arg Leu Gly Ser
              85                  90                  95

 tcc ctg ctg gat gaa gcc atc gag gct gtg gcg act ggc ctg agc act      812
 Ser Leu Leu Asp Glu Ala Ile Glu Ala Val Ala Thr Gly Leu Ser Thr
         100                 105                 110

 gcc gtg tat cag cgc ccc ctg acg ccg cgc act ccc gcc cga cgg aag      860
 Ala Val Tyr Gln Arg Pro Leu Thr Pro Arg Thr Pro Ala Arg Arg Lys
     115                 120                 125

 agg aag aca aga aga cgg aag aaa gtg ccg gga aga aag aaa acc ccg      908
 Arg Lys Thr Arg Arg Arg Lys Lys Val Pro Gly Arg Lys Lys Thr Pro
 130                 135                 140                 145

 tcc gga cca tcc gca aaa agt aag agc tca gcg aca aga tct aag aaa      956
 Ser Gly Pro Ser Ala Lys Ser Lys Ser Ser Ala Thr Arg Ser Lys Lys
                 150                 155                 160

 cgc caa cat cga gtg aag aag aga aga ggg aag aag gta aag agt gaa     1004
 Arg Gln His Arg Val Lys Lys Arg Arg Gly Lys Lys Val Lys Ser Glu
             165                 170                 175

 gcc acc act cgc tct cga atc gcg cgg acg ctg ggc ctg cgc agg cct     1052
 Ala Thr Thr Arg Ser Arg Ile Ala Arg Thr Leu Gly Leu Arg Arg Pro
         180                 185                 190

 gtt cac agc agc tgc atc ccg tca gtg ttg aag cca gtg gag ccc tct     1100
 Val His Ser Ser Cys Ile Pro Ser Val Leu Lys Pro Val Glu Pro Ser
     195                 200                 205

 ttg ggg ctg ctg aga gcg gat att gga gct gcc tct ctg tct ctg ttt     1148
 Leu Gly Leu Leu Arg Ala Asp Ile Gly Ala Ala Ser Leu Ser Leu Phe
 210                 215                 220                 225

 gga gat cct tat gag ctg gat ccc ttc gac agc agt gaa gag ctt tct     1196
 Gly Asp Pro Tyr Glu Leu Asp Pro Phe Asp Ser Ser Glu Glu Leu Ser
                 230                 235                 240

 gca aac cct ctt tcc cct ctg agt gcc aag aga cgg gct ctg tcc cgg     1244
 Ala Asn Pro Leu Ser Pro Leu Ser Ala Lys Arg Arg Ala Leu Ser Arg
             245                 250                 255

 tca gcc ctg cag tcc cac cag ccc gtg gcc agg ccc gtc tcc gtg ggg     1292
 Ser Ala Leu Gln Ser His Gln Pro Val Ala Arg Pro Val Ser Val Gly
         260                 265                 270

 ctt tcc agg agg cgc ctc cct gcc gcg gtg cca gag cca gac ttg gag     1340
 Leu Ser Arg Arg Arg Leu Pro Ala Ala Val Pro Glu Pro Asp Leu Glu
     275                 280                 285

 gag gag cca gtg cct gac ctg ctg ggc agc atc ctg tcg ggc cag agc     1388
 Glu Glu Pro Val Pro Asp Leu Leu Gly Ser Ile Leu Ser Gly Gln Ser
 290                 295                 300                 305

 ccc ctg atg ctg ggc agc agt gat gtc atc atc cac cgc gac ggc tcc     1436
 Pro Leu Met Leu Gly Ser Ser Asp Val Ile Ile His Arg Asp Gly Ser
                 310                 315                 320

 ctc agc gcc aag agg gcg gct cca gtt tct ttt cag cga aac tca ggc     1484
 Leu Ser Ala Lys Arg Ala Ala Pro Val Ser Phe Gln Arg Asn Ser Gly
             325                 330                 335

 agt ctg tcc aga ggg gaa gaa gga ttc aag ggc tgc ctg cag ccc cga     1532
 Ser Leu Ser Arg Gly Glu Glu Gly Phe Lys Gly Cys Leu Gln Pro Arg
         340                 345                 350

 gca ctg ccc tcc ggg agc ccg gcc caa ggc ccg tca gga aac agg cca     1580
 Ala Leu Pro Ser Gly Ser Pro Ala Gln Gly Pro Ser Gly Asn Arg Pro
     355                 360                 365

 cag agc aca ggg ctc agc tgt caa ggc agg tcc cgc acc ccc gcc cgc     1628
 Gln Ser Thr Gly Leu Ser Cys Gln Gly Arg Ser Arg Thr Pro Ala Arg
 370                 375                 380                 385

 acc gcg ggg gcg cct gtg agg ctg gac ttg cca gca gcc cct ggg gcg     1676
 Thr Ala Gly Ala Pro Val Arg Leu Asp Leu Pro Ala Ala Pro Gly Ala
                 390                 395                 400

 gtt cag gct cgg aac ttg tca aat ggg agt gtg cct ggc ttc aga cag     1724
 Val Gln Ala Arg Asn Leu Ser Asn Gly Ser Val Pro Gly Phe Arg Gln
             405                 410                 415

 agc cac agc ccc tgg ttc aac ggc acc aac aag cac acc ttg ccc ctt     1772
 Ser His Ser Pro Trp Phe Asn Gly Thr Asn Lys His Thr Leu Pro Leu
         420                 425                 430

 gcc tct gcc gcg tct aag atc tca agc aga gat tct aag ccc cca tgt     1820
 Ala Ser Ala Ala Ser Lys Ile Ser Ser Arg Asp Ser Lys Pro Pro Cys
     435                 440                 445

 cgc agt gtg gtg ccg ggg cct ccc ctg aag cca gcg ccc aga aga aca     1868
 Arg Ser Val Val Pro Gly Pro Pro Leu Lys Pro Ala Pro Arg Arg Thr
 450                 455                 460                 465

 gac atc tct gag cta ccc agg ata cca aag atc agg aga gat gac ggt     1916
 Asp Ile Ser Glu Leu Pro Arg Ile Pro Lys Ile Arg Arg Asp Asp Gly
                 470                 475                 480

 ggt ggc aga cgg gat gcg gcc ccg gcc cac ggg cag agc att gag atc     1964
 Gly Gly Arg Arg Asp Ala Ala Pro Ala His Gly Gln Ser Ile Glu Ile
             485                 490                 495

 ccc agt gcc tgc atc agc cga ctg act ggc agg gag ggc acc ggg cag     2012
 Pro Ser Ala Cys Ile Ser Arg Leu Thr Gly Arg Glu Gly Thr Gly Gln
         500                 505                 510

 cca ggg cga ggc aca cgg gca gag agc gag gcc agc agc agg gtg ccc     2060
 Pro Gly Arg Gly Thr Arg Ala Glu Ser Glu Ala Ser Ser Arg Val Pro
     515                 520                 525

 cgg gag ccc ggg gtg cac acg ggc agc tcc cgg ccc cca gcc ccc agc     2108
 Arg Glu Pro Gly Val His Thr Gly Ser Ser Arg Pro Pro Ala Pro Ser
 530                 535                 540                 545

 tcc cat ggc agt ttg gcc cca ctg gga cca tca aga ggg aaa ggg gtc     2156
 Ser His Gly Ser Leu Ala Pro Leu Gly Pro Ser Arg Gly Lys Gly Val
                 550                 555                 560

 ggg tcg acc ttt gag agc ttc cgg atc aat att cct gga aac atg gca     2204
 Gly Ser Thr Phe Glu Ser Phe Arg Ile Asn Ile Pro Gly Asn Met Ala
             565                 570                 575

 cat tcc agc cag ctc tcc agc cct ggc ttc tgt aac acg ttc cgg cct     2252
 His Ser Ser Gln Leu Ser Ser Pro Gly Phe Cys Asn Thr Phe Arg Pro
         580                 585                 590

 gtg gac gat aag gag cag agg aag gag aac ccc tca ccc ctc ttc tcc     2300
 Val Asp Asp Lys Glu Gln Arg Lys Glu Asn Pro Ser Pro Leu Phe Ser
     595                 600                 605

 atc aag aag acg aag cag ctg cgg agc gag gtc tac gac cca tcc gac     2348
 Ile Lys Lys Thr Lys Gln Leu Arg Ser Glu Val Tyr Asp Pro Ser Asp
 610                 615                 620                 625

 ccc acc ggc tcc gac tcc agc gcc cct ggc agc agc ccc gag agg tct     2396
 Pro Thr Gly Ser Asp Ser Ser Ala Pro Gly Ser Ser Pro Glu Arg Ser
                 630                 635                 640

 ggc ccc ggc ctc ctg ccc tct gag atc aca cga acc atc tcc atc aac     2444
 Gly Pro Gly Leu Leu Pro Ser Glu Ile Thr Arg Thr Ile Ser Ile Asn
             645                 650                 655

 agc ccg aag gcc cag acg gtg cag gct gtg cgc tgc gtc acc tcc tac     2492
 Ser Pro Lys Ala Gln Thr Val Gln Ala Val Arg Cys Val Thr Ser Tyr
         660                 665                 670

 acg gtg gag agc atc ttt ggt aca gag ccc gaa ccc cct ctc gga ccg     2540
 Thr Val Glu Ser Ile Phe Gly Thr Glu Pro Glu Pro Pro Leu Gly Pro
     675                 680                 685

 tcc tcc gcc atg tcc aag ctc cgg ggt gca gtg gct gcc gag ggg gcc     2588
 Ser Ser Ala Met Ser Lys Leu Arg Gly Ala Val Ala Ala Glu Gly Ala
 690                 695                 700                 705

 tct gac acg gag cga gag gag ccc aca gag agc cag ggc ctg gct gcc     2636
 Ser Asp Thr Glu Arg Glu Glu Pro Thr Glu Ser Gln Gly Leu Ala Ala
                 710                 715                 720

 cgg ctg cgg agg cca tcc ccc cca gag ccc tgg gat gag gag gat ggg     2684
 Arg Leu Arg Arg Pro Ser Pro Pro Glu Pro Trp Asp Glu Glu Asp Gly
             725                 730                 735

 gcg tct tgc agc acc ttc ttt ggc tct gag gag cgg acg gtg acc tgt     2732
 Ala Ser Cys Ser Thr Phe Phe Gly Ser Glu Glu Arg Thr Val Thr Cys
         740                 745                 750

 gtg act gtc gtg gag ccg gaa gcc cca ccc agc ccg gac gtg ctg cag     2780
 Val Thr Val Val Glu Pro Glu Ala Pro Pro Ser Pro Asp Val Leu Gln
     755                 760                 765

 gct gcc acc cac aga gtc gtg gag ctc agg ccc cct tcc cgg tcc cgc     2828
 Ala Ala Thr His Arg Val Val Glu Leu Arg Pro Pro Ser Arg Ser Arg
 770                 775                 780                 785

 tcc aca tcc agc tcc cgc agc agg aag aag gcc aag agg aag agg gtg     2876
 Ser Thr Ser Ser Ser Arg Ser Arg Lys Lys Ala Lys Arg Lys Arg Val
                 790                 795                 800

 tcc agg gag cac gga cgg acg cgc tct ggg acg cgc tct gaa tcc agg     2924
 Ser Arg Glu His Gly Arg Thr Arg Ser Gly Thr Arg Ser Glu Ser Arg
             805                 810                 815

 gac agg agc tcg agg tca gcg tca cca tca gtg ggt gag gag cgc ccc     2972
 Asp Arg Ser Ser Arg Ser Ala Ser Pro Ser Val Gly Glu Glu Arg Pro
         820                 825                 830

 agg agg cag cgg tcc aag gcc aag agc cgg cgg tcc tcc agt gac cgc     3020
 Arg Arg Gln Arg Ser Lys Ala Lys Ser Arg Arg Ser Ser Ser Asp Arg
     835                 840                 845

 tcc agc agc cga gag cga gct aag agg aag aaa gcc aag gac aag agc     3068
 Ser Ser Ser Arg Glu Arg Ala Lys Arg Lys Lys Ala Lys Asp Lys Ser
 850                 855                 860                 865

 agg gag cac agg cgg ggc ccc tgg ggc cac agc cgg agg acg tcc cgg     3116
 Arg Glu His Arg Arg Gly Pro Trp Gly His Ser Arg Arg Thr Ser Arg
                 870                 875                 880

 tcg cgg tcg ggg agc cct ggc agc tct tcc tat gag cac tat gag agt     3164
 Ser Arg Ser Gly Ser Pro Gly Ser Ser Ser Tyr Glu His Tyr Glu Ser
             885                 890                 895

 agg aag aag aag aaa agg aga tca gcg tcc aga cct cgg gga agg gag     3212
 Arg Lys Lys Lys Lys Arg Arg Ser Ala Ser Arg Pro Arg Gly Arg Glu
         900                 905                 910

 tgc tcc ccc acc agc agc ctg gag agg ctc tgc agg cac aag cat cag     3260
 Cys Ser Pro Thr Ser Ser Leu Glu Arg Leu Cys Arg His Lys His Gln
     915                 920                 925

 cgg gaa cgc agc cac gag cgg cca gac agg aag gag agt gtg gcg tgg     3308
 Arg Glu Arg Ser His Glu Arg Pro Asp Arg Lys Glu Ser Val Ala Trp
 930                 935                 940                 945

 ccc cga gac cgg agg aag cgg agg tcc cgg tcc cca agc tcg gag cac     3356
 Pro Arg Asp Arg Arg Lys Arg Arg Ser Arg Ser Pro Ser Ser Glu His
                 950                 955                 960

 agg gca cgg gag cac agg cgg cct cgg tcc cgt gag aag tgg ccg cag     3404
 Arg Ala Arg Glu His Arg Arg Pro Arg Ser Arg Glu Lys Trp Pro Gln
             965                 970                 975

 acc cgg tcc cat tcc cca gag agg aag ggg gct gtg agg gag gct tcc     3452
 Thr Arg Ser His Ser Pro Glu Arg Lys Gly Ala Val Arg Glu Ala Ser
         980                 985                 990

 cca gcg ccc ctt gca cag ggg gag cca ggg cgg gaa gac ctc ccc acc     3500
 Pro Ala Pro Leu Ala Gln Gly Glu Pro Gly Arg Glu Asp Leu Pro Thr
     995                1000                1005

 agg ttg cca gcc ttg ggg gaa gca cat gtc tcg ccg gag gtg gct acg     3548
 Arg Leu Pro Ala Leu Gly Glu Ala His Val Ser Pro Glu Val Ala Thr
1010                1015                1020                1025

 gcc gac aag gcc ccc ctg cag gct ccc cct gtc ctg gag gtg gca gct     3596
 Ala Asp Lys Ala Pro Leu Gln Ala Pro Pro Val Leu Glu Val Ala Ala
                1030                1035                1040

 gag tgt gag ccg gac gac ctg gac ctg gat tat ggc gac tcc gtg gag     3644
 Glu Cys Glu Pro Asp Asp Leu Asp Leu Asp Tyr Gly Asp Ser Val Glu
            1045                1050                1055

 gcc gga cac gtc ttt gat gat ttc tca agc gac gcc gtt ttc atc cag     3692
 Ala Gly His Val Phe Asp Asp Phe Ser Ser Asp Ala Val Phe Ile Gln
        1060                1065                1070

 ctc gat gac atg agc tcg cca cct tct ccc gaa agc aca gac tct tcc     3740
 Leu Asp Asp Met Ser Ser Pro Pro Ser Pro Glu Ser Thr Asp Ser Ser
    1075                1080                1085

 ccg gag cga gac ttc cca ctg aag cct gcg ttg ccc cca gcc agc ctg     3788
 Pro Glu Arg Asp Phe Pro Leu Lys Pro Ala Leu Pro Pro Ala Ser Leu
1090                1095                1100                1105

 gcc gtg gcc gcc atc cag agg gag gtg tca ttg atg cac gat gaa gac     3836
 Ala Val Ala Ala Ile Gln Arg Glu Val Ser Leu Met His Asp Glu Asp
                1110                1115                1120

 cct tcg cag ccc cca ccc ctg cca gag ggc acc cag gag cca cat ttg     3884
 Pro Ser Gln Pro Pro Pro Leu Pro Glu Gly Thr Gln Glu Pro His Leu
            1125                1130                1135

 ctc agg ccg gac gcg gct gag aag gct gag gca ccc agt tcc ccg gat     3932
 Leu Arg Pro Asp Ala Ala Glu Lys Ala Glu Ala Pro Ser Ser Pro Asp
        1140                1145                1150

 gtg gcg cct gcg ggg aag gaa gac agc ccc tct gcg agt ggg agg gta     3980
 Val Ala Pro Ala Gly Lys Glu Asp Ser Pro Ser Ala Ser Gly Arg Val
    1155                1160                1165

 cag gag gca gcc cgg cct gag gag gtg gtt tcg cag acc ccc ctg ctg     4028
 Gln Glu Ala Ala Arg Pro Glu Glu Val Val Ser Gln Thr Pro Leu Leu
1170                1175                1180                1185

 cgg tcc aga gcc ctg gtg aag cgg gtc acc tgg aac ctg cag gag tcg     4076
 Arg Ser Arg Ala Leu Val Lys Arg Val Thr Trp Asn Leu Gln Glu Ser
                1190                1195                1200

 gag agc agc gcc ccc gcc gag gac aga gcc ccc cgg gca cca ctt cac     4124
 Glu Ser Ser Ala Pro Ala Glu Asp Arg Ala Pro Arg Ala Pro Leu His
            1205                1210                1215

 agg cca cag aag ccc cga gaa gga gcc tgg gac atg gag gat gtg gcc     4172
 Arg Pro Gln Lys Pro Arg Glu Gly Ala Trp Asp Met Glu Asp Val Ala
        1220                1225                1230

 ccc aca ggg gtc agg cag gcg ttc tcc gag ctg ccc ttt ccc agt cac     4220
 Pro Thr Gly Val Arg Gln Ala Phe Ser Glu Leu Pro Phe Pro Ser His
    1235                1240                1245

 gtg ctt ccg gaa ccc ggg ttc cca gac aca gac ccc tct cag gtt tac     4268
 Val Leu Pro Glu Pro Gly Phe Pro Asp Thr Asp Pro Ser Gln Val Tyr
1250                1255                1260                1265

 agc ccc ggc ctg ccg cct gcc ccg gcc cag ccc tca agc atc cca ccc     4316
 Ser Pro Gly Leu Pro Pro Ala Pro Ala Gln Pro Ser Ser Ile Pro Pro
                1270                1275                1280

 tgc gca ctg gtc agc cag ccc acg gtc cag ttc atc ctt cag ggg agc     4364
 Cys Ala Leu Val Ser Gln Pro Thr Val Gln Phe Ile Leu Gln Gly Ser
            1285                1290                1295

 ctg ccg cta gtg ggc tgt ggg gca gca cag acc ctg gcc cca gtg ccc     4412
 Leu Pro Leu Val Gly Cys Gly Ala Ala Gln Thr Leu Ala Pro Val Pro
        1300                1305                1310

 gct gcc ctg acc cca gcc tca gag cca gcc agt caa gcc act gca gcc     4460
 Ala Ala Leu Thr Pro Ala Ser Glu Pro Ala Ser Gln Ala Thr Ala Ala
    1315                1320                1325

 agc aac tcg gag gag aag acc ccg gcc ccc agg cta gct gcg gag aaa     4508
 Ser Asn Ser Glu Glu Lys Thr Pro Ala Pro Arg Leu Ala Ala Glu Lys
1330                1335                1340                1345

 acc aag aag gag gag tac atg aag aag ctg cac atg cag gag cgt gct     4556
 Thr Lys Lys Glu Glu Tyr Met Lys Lys Leu His Met Gln Glu Arg Ala
                1350                1355                1360

 gtg gag gag gtg aag ctg gcc atc aag ccc ttc tac cag aag agg gag     4604
 Val Glu Glu Val Lys Leu Ala Ile Lys Pro Phe Tyr Gln Lys Arg Glu
            1365                1370                1375

 gtg acc aag gag gag tac aag gac atc ctg cgc aag gcc gtg cag aag     4652
 Val Thr Lys Glu Glu Tyr Lys Asp Ile Leu Arg Lys Ala Val Gln Lys
        1380                1385                1390

 atc tgc cac agc aag agt gga gag atc aac ccc gtg aag gtg gcc aac     4700
 Ile Cys His Ser Lys Ser Gly Glu Ile Asn Pro Val Lys Val Ala Asn
    1395                1400                1405

 ctg gtg aag gcg tac gtg gac aag tac agg cac atg cgc agg cac aag     4748
 Leu Val Lys Ala Tyr Val Asp Lys Tyr Arg His Met Arg Arg His Lys
1410                1415                1420                1425

 aaa cca gag gcc ggg gag gag ccg ccc acg cag ggg gcc gag ggc tga     4796
 Lys Pro Glu Ala Gly Glu Glu Pro Pro Thr Gln Gly Ala Glu Gly 
                1430                1435                1440

 ggccaggcaa tcacgggcta tgcccgggga gctgtcggga gtggcgggaa tcggggccat   4856

 gcccggggag ctgtcgggag tggcgggaat cggggccatg cccggggagc tgtcgggagt   4916

 ggcgggaaat ggggggcatc accatgcctg ccgtcgggtt cctgcgctga cacctggtct   4976

 gtgcacctgt gttgctcaca gttgaaaact ggacactttt gtatgtatat tatagagaca   5036

 ctgtttccat tctaatttat caaaaatgga ttatctttag aaacctcttg attgacttac   5096

 tacttggaag ataaagcact tggtgatcaa gaggggctcc tggtggggtg gcgcgtcctt   5156

 gataaatctc caggtggcct cccgccaaca gctgctgtgt acctttggct ctgaattagg   5216

 aatatcttta ctttctcttt tccaaaaaaa aaaaaaaaaa aagatcttct ctgccgaatc   5276

 tc                                                                  5278




      <210> 318
      <211> 5534
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(5052)

      <400> 318
 cgggtcgacg attccgtgcg actctcggtc gtgcagcggc ggcgagcgct cgcgagcggc     60

 tgcgggacgc gaggtttccg gagctgagct caatgtgcag ca   atg gat gac gac     114
                                                  Met Asp Asp Asp
                                                    1

 agc ctg gat gag ctt gtg gcc cgg agc cca ggg ccg gat gga cac cca      162
 Ser Leu Asp Glu Leu Val Ala Arg Ser Pro Gly Pro Asp Gly His Pro
   5                  10                  15                  20

 cag gtc ggc cct gcg gac ccg gca ggt gac ttt gaa gaa agc agc gtg      210
 Gln Val Gly Pro Ala Asp Pro Ala Gly Asp Phe Glu Glu Ser Ser Val
                  25                  30                  35

 ggc agc agt ggg gac tct ggg gac gac agt gac agc gag cat gga gat      258
 Gly Ser Ser Gly Asp Ser Gly Asp Asp Ser Asp Ser Glu His Gly Asp
              40                  45                  50

 ggc aca gac gga gaa gac gag ggg gcg tct gag gag gaa gac ctg gaa      306
 Gly Thr Asp Gly Glu Asp Glu Gly Ala Ser Glu Glu Glu Asp Leu Glu
          55                  60                  65

 gac aga tct ggt tcc gag gat tct gaa gac gac ggg gag aca ttg ctg      354
 Asp Arg Ser Gly Ser Glu Asp Ser Glu Asp Asp Gly Glu Thr Leu Leu
      70                  75                  80

 gag gta gcg ggt act cag ggg aaa ctg gaa gcc gct ggc tct ttc aat      402
 Glu Val Ala Gly Thr Gln Gly Lys Leu Glu Ala Ala Gly Ser Phe Asn
  85                  90                  95                 100

 tct gat gat gat gca gag agc tgc cca atc tgt ctc aac gca ttc aga      450
 Ser Asp Asp Asp Ala Glu Ser Cys Pro Ile Cys Leu Asn Ala Phe Arg
                 105                 110                 115

 gac cag gcc gtg ggg acg ccg gag aac tgt gcc cat tac ttc tgc ctg      498
 Asp Gln Ala Val Gly Thr Pro Glu Asn Cys Ala His Tyr Phe Cys Leu
             120                 125                 130

 gac tgc att gtc gaa tgg tcc aag aat gcc aat tcc tgt cca gtt gat      546
 Asp Cys Ile Val Glu Trp Ser Lys Asn Ala Asn Ser Cys Pro Val Asp
         135                 140                 145

 cga act cta ttt aag tgc att tgt att cga gct caa ttt ggt ggt aaa      594
 Arg Thr Leu Phe Lys Cys Ile Cys Ile Arg Ala Gln Phe Gly Gly Lys
     150                 155                 160

 atc tta aga aag atc cca gtg gag aac acc aaa gcg agc gag gag gag      642
 Ile Leu Arg Lys Ile Pro Val Glu Asn Thr Lys Ala Ser Glu Glu Glu
 165                 170                 175                 180

 gag gac ccg acc ttc tgt gag gtg tgc ggc agg agc gac cgt gag gac      690
 Glu Asp Pro Thr Phe Cys Glu Val Cys Gly Arg Ser Asp Arg Glu Asp
                 185                 190                 195

 agg ctt ttg ctc tgc gac ggc tgc gat gcg ggg tac cac atg gaa tgc      738
 Arg Leu Leu Leu Cys Asp Gly Cys Asp Ala Gly Tyr His Met Glu Cys
             200                 205                 210

 ttg gac ccc cct ctc cag gag gtg ccg gtg gac gag tgg ttc tgc ccg      786
 Leu Asp Pro Pro Leu Gln Glu Val Pro Val Asp Glu Trp Phe Cys Pro
         215                 220                 225

 gaa tgt gct gcg cct ggt gtt gtc ctt gcc gct gat gcg ggt ccc gtg      834
 Glu Cys Ala Ala Pro Gly Val Val Leu Ala Ala Asp Ala Gly Pro Val
     230                 235                 240

 agt gag gag gag gtc tcc ctg ctc ttg gct gat gtg gtg ccc acc acc      882
 Ser Glu Glu Glu Val Ser Leu Leu Leu Ala Asp Val Val Pro Thr Thr
 245                 250                 255                 260

 agc agg ctt cgg cct cga gca ggt agg acc cgg gcg ata gcc agg aca      930
 Ser Arg Leu Arg Pro Arg Ala Gly Arg Thr Arg Ala Ile Ala Arg Thr
                 265                 270                 275

 cgg cag agt gag aga gtg aga gca acc gtg aac cgg aac cgg atc tcc      978
 Arg Gln Ser Glu Arg Val Arg Ala Thr Val Asn Arg Asn Arg Ile Ser
             280                 285                 290

 acg gcc agg agg gtc cag cac aca cca ggg cgc ctc ggg tct tcc ctg     1026
 Thr Ala Arg Arg Val Gln His Thr Pro Gly Arg Leu Gly Ser Ser Leu
         295                 300                 305

 ctg gat gaa gcc atc gag gct gtg gcg act ggc ctg agc act gcc gtg     1074
 Leu Asp Glu Ala Ile Glu Ala Val Ala Thr Gly Leu Ser Thr Ala Val
     310                 315                 320

 tat cag cgc ccc ctg acg ccg cgc act ccc gcc cga cgg aag agg aag     1122
 Tyr Gln Arg Pro Leu Thr Pro Arg Thr Pro Ala Arg Arg Lys Arg Lys
 325                 330                 335                 340

 aca aga aga cgg aag aaa gtg ccg gga aga aag aaa acc ccg tcc gga     1170
 Thr Arg Arg Arg Lys Lys Val Pro Gly Arg Lys Lys Thr Pro Ser Gly
                 345                 350                 355

 cca tcc gca aaa agt aag agc tca gcg aca aga tct aag aaa cgc caa     1218
 Pro Ser Ala Lys Ser Lys Ser Ser Ala Thr Arg Ser Lys Lys Arg Gln
             360                 365                 370

 cat cga gtg aag aag aga aga ggg aag aag gta aag agt gaa gcc acc     1266
 His Arg Val Lys Lys Arg Arg Gly Lys Lys Val Lys Ser Glu Ala Thr
         375                 380                 385

 act cgc tct cga atc gcg cgg acg ctg ggc ctg cgc agg cct gtt cac     1314
 Thr Arg Ser Arg Ile Ala Arg Thr Leu Gly Leu Arg Arg Pro Val His
     390                 395                 400

 agc agc tgc atc ccg tca gtg ttg aag cca gtg gag ccc tct ttg ggg     1362
 Ser Ser Cys Ile Pro Ser Val Leu Lys Pro Val Glu Pro Ser Leu Gly
 405                 410                 415                 420

 ctg ctg aga gcg gat att gga gct gcc tct ctg tct ctg ttt gga gat     1410
 Leu Leu Arg Ala Asp Ile Gly Ala Ala Ser Leu Ser Leu Phe Gly Asp
                 425                 430                 435

 cct tat gag ctg gat ccc ttc gac agc agt gaa gag ctt tct gca aac     1458
 Pro Tyr Glu Leu Asp Pro Phe Asp Ser Ser Glu Glu Leu Ser Ala Asn
             440                 445                 450

 cct ctt tcc cct ctg agt gcc aag aga cgg gct ctg tcc cgg tca gcc     1506
 Pro Leu Ser Pro Leu Ser Ala Lys Arg Arg Ala Leu Ser Arg Ser Ala
         455                 460                 465

 ctg cag tcc cac cag ccc gtg gcc agg ccc gtc tcc gtg ggg ctt tcc     1554
 Leu Gln Ser His Gln Pro Val Ala Arg Pro Val Ser Val Gly Leu Ser
     470                 475                 480

 agg agg cgc ctc cct gcc gcg gtg cca gag cca gac ttg gag gag gag     1602
 Arg Arg Arg Leu Pro Ala Ala Val Pro Glu Pro Asp Leu Glu Glu Glu
 485                 490                 495                 500

 cca gtg cct gac ctg ctg ggc agc atc ctg tcg ggc cag agc ccc ctg     1650
 Pro Val Pro Asp Leu Leu Gly Ser Ile Leu Ser Gly Gln Ser Pro Leu
                 505                 510                 515

 atg ctg ggc agc agt gat gtc atc atc cac cgc gac ggc tcc ctc agc     1698
 Met Leu Gly Ser Ser Asp Val Ile Ile His Arg Asp Gly Ser Leu Ser
             520                 525                 530

 gcc aag agg gcg gct cca gtt tct ttt cag cga aac tca ggc agt ctg     1746
 Ala Lys Arg Ala Ala Pro Val Ser Phe Gln Arg Asn Ser Gly Ser Leu
         535                 540                 545

 tcc aga ggg gaa gaa gga ttc aag ggc tgc ctg cag ccc cga gca ctg     1794
 Ser Arg Gly Glu Glu Gly Phe Lys Gly Cys Leu Gln Pro Arg Ala Leu
     550                 555                 560

 ccc tcc ggg agc ccg gcc caa ggc ccg tca gga aac agg cca cag agc     1842
 Pro Ser Gly Ser Pro Ala Gln Gly Pro Ser Gly Asn Arg Pro Gln Ser
 565                 570                 575                 580

 aca ggg ctc agc tgt caa ggc agg tcc cgc acc ccc gcc cgc acc gcg     1890
 Thr Gly Leu Ser Cys Gln Gly Arg Ser Arg Thr Pro Ala Arg Thr Ala
                 585                 590                 595

 ggg gcg cct gtg agg ctg gac ttg cca gca gcc cct ggg gcg gtt cag     1938
 Gly Ala Pro Val Arg Leu Asp Leu Pro Ala Ala Pro Gly Ala Val Gln
             600                 605                 610

 gct cgg aac ttg tca aat ggg agt gtg cct ggc ttc aga cag agc cac     1986
 Ala Arg Asn Leu Ser Asn Gly Ser Val Pro Gly Phe Arg Gln Ser His
         615                 620                 625

 agc ccc tgg ttc aac ggc acc aac aag cac acc ttg ccc ctt gcc tct     2034
 Ser Pro Trp Phe Asn Gly Thr Asn Lys His Thr Leu Pro Leu Ala Ser
     630                 635                 640

 gcc gcg tct aag atc tca agc aga gat tct aag ccc cca tgt cgc agt     2082
 Ala Ala Ser Lys Ile Ser Ser Arg Asp Ser Lys Pro Pro Cys Arg Ser
 645                 650                 655                 660

 gtg gtg ccg ggg cct ccc ctg aag cca gcg ccc aga aga aca gac atc     2130
 Val Val Pro Gly Pro Pro Leu Lys Pro Ala Pro Arg Arg Thr Asp Ile
                 665                 670                 675

 tct gag cta ccc agg ata cca aag atc agg aga gat gac ggt ggt ggc     2178
 Ser Glu Leu Pro Arg Ile Pro Lys Ile Arg Arg Asp Asp Gly Gly Gly
             680                 685                 690

 aga cgg gat gcg gcc ccg gcc cac ggg cag agc att gag atc ccc agt     2226
 Arg Arg Asp Ala Ala Pro Ala His Gly Gln Ser Ile Glu Ile Pro Ser
         695                 700                 705

 gcc tgc atc agc cga ctg act ggc agg gag ggc acc ggg cag cca ggg     2274
 Ala Cys Ile Ser Arg Leu Thr Gly Arg Glu Gly Thr Gly Gln Pro Gly
     710                 715                 720

 cga ggc aca cgg gca gag agc gag gcc agc agc agg gtg ccc cgg gag     2322
 Arg Gly Thr Arg Ala Glu Ser Glu Ala Ser Ser Arg Val Pro Arg Glu
 725                 730                 735                 740

 ccc ggg gtg cac acg ggc agc tcc cgg ccc cca gcc ccc agc tcc cat     2370
 Pro Gly Val His Thr Gly Ser Ser Arg Pro Pro Ala Pro Ser Ser His
                 745                 750                 755

 ggc agt ttg gcc cca ctg gga cca tca aga ggg aaa ggg gtc ggg tcg     2418
 Gly Ser Leu Ala Pro Leu Gly Pro Ser Arg Gly Lys Gly Val Gly Ser
             760                 765                 770

 acc ttt gag agc ttc cgg atc aat att cct gga aac atg gca cat tcc     2466
 Thr Phe Glu Ser Phe Arg Ile Asn Ile Pro Gly Asn Met Ala His Ser
         775                 780                 785

 agc cag ctc tcc agc cct ggc ttc tgt aac acg ttc cgg cct gtg gac     2514
 Ser Gln Leu Ser Ser Pro Gly Phe Cys Asn Thr Phe Arg Pro Val Asp
     790                 795                 800

 gat aag gag cag agg aag gag aac ccc tca ccc ctc ttc tcc atc aag     2562
 Asp Lys Glu Gln Arg Lys Glu Asn Pro Ser Pro Leu Phe Ser Ile Lys
 805                 810                 815                 820

 aag acg aag cag ctg cgg agc gag gtc tac gac cca tcc gac ccc acc     2610
 Lys Thr Lys Gln Leu Arg Ser Glu Val Tyr Asp Pro Ser Asp Pro Thr
                 825                 830                 835

 ggc tcc gac tcc agc gcc cct ggc agc agc ccc gag agg tct ggc ccc     2658
 Gly Ser Asp Ser Ser Ala Pro Gly Ser Ser Pro Glu Arg Ser Gly Pro
             840                 845                 850

 ggc ctc ctg ccc tct gag atc aca cga acc atc tcc atc aac agc ccg     2706
 Gly Leu Leu Pro Ser Glu Ile Thr Arg Thr Ile Ser Ile Asn Ser Pro
         855                 860                 865

 aag gcc cag acg gtg cag gct gtg cgc tgc gtc acc tcc tac acg gtg     2754
 Lys Ala Gln Thr Val Gln Ala Val Arg Cys Val Thr Ser Tyr Thr Val
     870                 875                 880

 gag agc atc ttt ggt aca gag ccc gaa ccc cct ctc gga ccg tcc tcc     2802
 Glu Ser Ile Phe Gly Thr Glu Pro Glu Pro Pro Leu Gly Pro Ser Ser
 885                 890                 895                 900

 gcc atg tcc aag ctc cgg ggt gca gtg gct gcc gag ggg gcc tct gac     2850
 Ala Met Ser Lys Leu Arg Gly Ala Val Ala Ala Glu Gly Ala Ser Asp
                 905                 910                 915

 acg gag cga gag gag ccc aca gag agc cag ggc ctg gct gcc cgg ctg     2898
 Thr Glu Arg Glu Glu Pro Thr Glu Ser Gln Gly Leu Ala Ala Arg Leu
             920                 925                 930

 cgg agg cca tcc ccc cca gag ccc tgg gat gag gag gat ggg gcg tct     2946
 Arg Arg Pro Ser Pro Pro Glu Pro Trp Asp Glu Glu Asp Gly Ala Ser
         935                 940                 945

 tgc agc acc ttc ttt ggc tct gag gag cgg acg gtg acc tgt gtg act     2994
 Cys Ser Thr Phe Phe Gly Ser Glu Glu Arg Thr Val Thr Cys Val Thr
     950                 955                 960

 gtc gtg gag ccg gaa gcc cca ccc agc ccg gac gtg ctg cag gct gcc     3042
 Val Val Glu Pro Glu Ala Pro Pro Ser Pro Asp Val Leu Gln Ala Ala
 965                 970                 975                 980

 acc cac aga gtc gtg gag ctc agg ccc cct tcc cgg tcc cgc tcc aca     3090
 Thr His Arg Val Val Glu Leu Arg Pro Pro Ser Arg Ser Arg Ser Thr
                 985                 990                 995

 tcc agc tcc cgc agc agg aag aag gcc aag agg aag agg gtg tcc agg     3138
 Ser Ser Ser Arg Ser Arg Lys Lys Ala Lys Arg Lys Arg Val Ser Arg
            1000                1005                1010

 gag cac gga cgg acg cgc tct ggg acg cgc tct gaa tcc agg gac agg     3186
 Glu His Gly Arg Thr Arg Ser Gly Thr Arg Ser Glu Ser Arg Asp Arg
        1015                1020                1025

 agc tcg agg tca gcg tca cca tca gtg ggt gag gag cgc ccc agg agg     3234
 Ser Ser Arg Ser Ala Ser Pro Ser Val Gly Glu Glu Arg Pro Arg Arg
    1030                1035                1040

 cag cgg tcc aag gcc aag agc cgg cgg tcc tcc agt gac cgc tcc agc     3282
 Gln Arg Ser Lys Ala Lys Ser Arg Arg Ser Ser Ser Asp Arg Ser Ser
1045                1050                1055                1060

 agc cga gag cga gct aag agg aag aaa gcc aag gac aag agc agg gag     3330
 Ser Arg Glu Arg Ala Lys Arg Lys Lys Ala Lys Asp Lys Ser Arg Glu
                1065                1070                1075

 cac agg cgg ggc ccc tgg ggc cac agc cgg agg acg tcc cgg tcg cgg     3378
 His Arg Arg Gly Pro Trp Gly His Ser Arg Arg Thr Ser Arg Ser Arg
            1080                1085                1090

 tcg ggg agc cct ggc agc tct tcc tat gag cac tat gag agt agg aag     3426
 Ser Gly Ser Pro Gly Ser Ser Ser Tyr Glu His Tyr Glu Ser Arg Lys
        1095                1100                1105

 aag aag aaa agg aga tca gcg tcc aga cct cgg gga agg gag tgc tcc     3474
 Lys Lys Lys Arg Arg Ser Ala Ser Arg Pro Arg Gly Arg Glu Cys Ser
    1110                1115                1120

 ccc acc agc agc ctg gag agg ctc tgc agg cac aag cat cag cgg gaa     3522
 Pro Thr Ser Ser Leu Glu Arg Leu Cys Arg His Lys His Gln Arg Glu
1125                1130                1135                1140

 cgc agc cac gag cgg cca gac agg aag gag agt gtg gcg tgg ccc cga     3570
 Arg Ser His Glu Arg Pro Asp Arg Lys Glu Ser Val Ala Trp Pro Arg
                1145                1150                1155

 gac cgg agg aag cgg agg tcc cgg tcc cca agc tcg gag cac agg gca     3618
 Asp Arg Arg Lys Arg Arg Ser Arg Ser Pro Ser Ser Glu His Arg Ala
            1160                1165                1170

 cgg gag cac agg cgg cct cgg tcc cgt gag aag tgg ccg cag acc cgg     3666
 Arg Glu His Arg Arg Pro Arg Ser Arg Glu Lys Trp Pro Gln Thr Arg
        1175                1180                1185

 tcc cat tcc cca gag agg aag ggg gct gtg agg gag gct tcc cca gcg     3714
 Ser His Ser Pro Glu Arg Lys Gly Ala Val Arg Glu Ala Ser Pro Ala
    1190                1195                1200

 ccc ctt gca cag ggg gag cca ggg cgg gaa gac ctc ccc acc agg ttg     3762
 Pro Leu Ala Gln Gly Glu Pro Gly Arg Glu Asp Leu Pro Thr Arg Leu
1205                1210                1215                1220

 cca gcc ttg ggg gaa gca cat gtc tcg ccg gag gtg gct acg gcc gac     3810
 Pro Ala Leu Gly Glu Ala His Val Ser Pro Glu Val Ala Thr Ala Asp
                1225                1230                1235

 aag gcc ccc ctg cag gct ccc cct gtc ctg gag gtg gca gct gag tgt     3858
 Lys Ala Pro Leu Gln Ala Pro Pro Val Leu Glu Val Ala Ala Glu Cys
            1240                1245                1250

 gag ccg gac gac ctg gac ctg gat tat ggc gac tcc gtg gag gcc gga     3906
 Glu Pro Asp Asp Leu Asp Leu Asp Tyr Gly Asp Ser Val Glu Ala Gly
        1255                1260                1265

 cac gtc ttt gat gat ttc tca agc gac gcc gtt ttc atc cag ctc gat     3954
 His Val Phe Asp Asp Phe Ser Ser Asp Ala Val Phe Ile Gln Leu Asp
    1270                1275                1280

 gac atg agc tcg cca cct tct ccc gaa agc aca gac tct tcc ccg gag     4002
 Asp Met Ser Ser Pro Pro Ser Pro Glu Ser Thr Asp Ser Ser Pro Glu
1285                1290                1295                1300

 cga gac ttc cca ctg aag cct gcg ttg ccc cca gcc agc ctg gcc gtg     4050
 Arg Asp Phe Pro Leu Lys Pro Ala Leu Pro Pro Ala Ser Leu Ala Val
                1305                1310                1315

 gcc gcc atc cag agg gag gtg tca ttg atg cac gat gaa gac cct tcg     4098
 Ala Ala Ile Gln Arg Glu Val Ser Leu Met His Asp Glu Asp Pro Ser
            1320                1325                1330

 cag ccc cca ccc ctg cca gag ggc acc cag gag cca cat ttg ctc agg     4146
 Gln Pro Pro Pro Leu Pro Glu Gly Thr Gln Glu Pro His Leu Leu Arg
        1335                1340                1345

 ccg gac gcg gct gag aag gct gag gca ccc agt tcc ccg gat gtg gcg     4194
 Pro Asp Ala Ala Glu Lys Ala Glu Ala Pro Ser Ser Pro Asp Val Ala
    1350                1355                1360

 cct gcg ggg aag gaa gac agc ccc tct gcg agt ggg agg gta cag gag     4242
 Pro Ala Gly Lys Glu Asp Ser Pro Ser Ala Ser Gly Arg Val Gln Glu
1365                1370                1375                1380

 gca gcc cgg cct gag gag gtg gtt tcg cag acc ccc ctg ctg cgg tcc     4290
 Ala Ala Arg Pro Glu Glu Val Val Ser Gln Thr Pro Leu Leu Arg Ser
                1385                1390                1395

 aga gcc ctg gtg aag cgg gtc acc tgg aac ctg cag gag tcg gag agc     4338
 Arg Ala Leu Val Lys Arg Val Thr Trp Asn Leu Gln Glu Ser Glu Ser
            1400                1405                1410

 agc gcc ccc gcc gag gac aga gcc ccc cgg gca cca ctt cac agg cca     4386
 Ser Ala Pro Ala Glu Asp Arg Ala Pro Arg Ala Pro Leu His Arg Pro
        1415                1420                1425

 cag aag ccc cga gaa gga gcc tgg gac atg gag gat gtg gcc ccc aca     4434
 Gln Lys Pro Arg Glu Gly Ala Trp Asp Met Glu Asp Val Ala Pro Thr
    1430                1435                1440

 ggg gtc agg cag gcg ttc tcc gag ctg ccc ttt ccc agt cac gtg ctt     4482
 Gly Val Arg Gln Ala Phe Ser Glu Leu Pro Phe Pro Ser His Val Leu
1445                1450                1455                1460

 ccg gaa ccc ggg ttc cca gac aca gac ccc tct cag gtt tac agc ccc     4530
 Pro Glu Pro Gly Phe Pro Asp Thr Asp Pro Ser Gln Val Tyr Ser Pro
                1465                1470                1475

 ggc ctg ccg cct gcc ccg gcc cag ccc tca agc atc cca ccc tgc gca     4578
 Gly Leu Pro Pro Ala Pro Ala Gln Pro Ser Ser Ile Pro Pro Cys Ala
            1480                1485                1490

 ctg gtc agc cag ccc acg gtc cag ttc atc ctt cag ggg agc ctg ccg     4626
 Leu Val Ser Gln Pro Thr Val Gln Phe Ile Leu Gln Gly Ser Leu Pro
        1495                1500                1505

 cta gtg ggc tgt ggg gca gca cag acc ctg gcc cca gtg ccc gct gcc     4674
 Leu Val Gly Cys Gly Ala Ala Gln Thr Leu Ala Pro Val Pro Ala Ala
    1510                1515                1520

 ctg acc cca gcc tca gag cca gcc agt caa gcc act gca gcc agc aac     4722
 Leu Thr Pro Ala Ser Glu Pro Ala Ser Gln Ala Thr Ala Ala Ser Asn
1525                1530                1535                1540

 tcg gag gag aag acc ccg gcc ccc agg cta gct gcg gag aaa acc aag     4770
 Ser Glu Glu Lys Thr Pro Ala Pro Arg Leu Ala Ala Glu Lys Thr Lys
                1545                1550                1555

 aag gag gag tac atg aag aag ctg cac atg cag gag cgt gct gtg gag     4818
 Lys Glu Glu Tyr Met Lys Lys Leu His Met Gln Glu Arg Ala Val Glu
            1560                1565                1570

 gag gtg aag ctg gcc atc aag ccc ttc tac cag aag agg gag gtg acc     4866
 Glu Val Lys Leu Ala Ile Lys Pro Phe Tyr Gln Lys Arg Glu Val Thr
        1575                1580                1585

 aag gag gag tac aag gac atc ctg cgc aag gcc gtg cag aag atc tgc     4914
 Lys Glu Glu Tyr Lys Asp Ile Leu Arg Lys Ala Val Gln Lys Ile Cys
    1590                1595                1600

 cac agc aag agt gga gag atc aac ccc gtg aag gtg gcc aac ctg gtg     4962
 His Ser Lys Ser Gly Glu Ile Asn Pro Val Lys Val Ala Asn Leu Val
1605                1610                1615                1620

 aag gcg tac gtg gac aag tac agg cac atg cgc agg cac aag aaa cca     5010
 Lys Ala Tyr Val Asp Lys Tyr Arg His Met Arg Arg His Lys Lys Pro
                1625                1630                1635

 gag gcc ggg gag gag ccg ccc acg cag ggg gcc gag ggc tga ggccagg     5059
 Glu Ala Gly Glu Glu Pro Pro Thr Gln Gly Ala Glu Gly 
            1640                1645

 caatcacggg ctatgcccgg ggagctgtcg ggagtggcgg gaatcggggc catgcccggg   5119

 gagctgtcgg gagtggcggg aatcggggcc atgcccgggg agctgtcggg agtggcggga   5179

 aatggggggc atcaccatgc ctgccgtcgg gttcctgcgc tgacacctgg tctgtgcacc   5239

 tgtgttgctc acagttgaaa actggacact tttgtatgta tattatagag acactgtttc   5299

 cattctaatt tatcaaaaat ggattatctt tagaaacctc ttgattgact tactacttgg   5359

 aagataaagc acttggtgat caagaggggc tcctggtggg gtggcgcgtc cttgataaat   5419

 ctccaggtgg cctcccgcca acagctgctg tgtacctttg gctctgaatt aggaatatct   5479

 ttactttctc ttttccaaaa aaaaaaaaaa aaaaagatct tctctgccga atctc        5534




      <210> 319
      <211> 4340
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (234)..(4070)

      <220>
      <221> misc_feature
      <222> (1)...(4340)
      <223> n = a,t,c or g

      <400> 319
 gcccagtcag ggcgtcgccc cnattgagnc catgagatcg tcgcgaccga cgcaccggnc     60

 cggaattccc gggtcgacga tttcgtcgtc gccgccgccg ccgccgccgc atcttgggag    120

 gtgctgccac cacaggtacc tgcacatgtt gttctttgtc agtgctgtca agtgtgtgcc    180

 agggtgatcc atggtcactt tccgggatgg cagcaaggtg acttcggctg agg   atg     236
                                                              Met
                                                                1

 acc ctg act gaa agg ctg cgt gag aag ata tct cgg gcc ttc tac aac      284
 Thr Leu Thr Glu Arg Leu Arg Glu Lys Ile Ser Arg Ala Phe Tyr Asn
               5                  10                  15

 cat ggg ctc ctc tgt gca tcc tat ccc atc ccc atc atc ctc ttc aca      332
 His Gly Leu Leu Cys Ala Ser Tyr Pro Ile Pro Ile Ile Leu Phe Thr
          20                  25                  30

 ggg ttc tgc atc tta gcc tgc tgc tac cca ctg ctg aaa ctc ccc ttg      380
 Gly Phe Cys Ile Leu Ala Cys Cys Tyr Pro Leu Leu Lys Leu Pro Leu
      35                  40                  45

 cca gga aca gga cct gtg gaa ttc acc acc cct gtg aag gat tac tcg      428
 Pro Gly Thr Gly Pro Val Glu Phe Thr Thr Pro Val Lys Asp Tyr Ser
  50                  55                  60                  65

 ccc cca cct gtg gac tct gac cgc aaa caa gga gag cct act gag cag      476
 Pro Pro Pro Val Asp Ser Asp Arg Lys Gln Gly Glu Pro Thr Glu Gln
                  70                  75                  80

 cct gag tgg tat gtg ggt gcc ccg gtg gct tat gtc cag cag ata ttt      524
 Pro Glu Trp Tyr Val Gly Ala Pro Val Ala Tyr Val Gln Gln Ile Phe
              85                  90                  95

 gtg aag tcc tca gtg ttt ccc tgg cac aag aac ctc ctg gca gta gat      572
 Val Lys Ser Ser Val Phe Pro Trp His Lys Asn Leu Leu Ala Val Asp
         100                 105                 110

 gta ttt cgt tca cct ttg tcc cgg gca ttc caa ctg gtg gag gag atc      620
 Val Phe Arg Ser Pro Leu Ser Arg Ala Phe Gln Leu Val Glu Glu Ile
     115                 120                 125

 cgg aac cac gtg ctg aga gac agc tct ggg atc agg agc ttg gag gag      668
 Arg Asn His Val Leu Arg Asp Ser Ser Gly Ile Arg Ser Leu Glu Glu
 130                 135                 140                 145

 ttg tgt ctg caa gtg acc gac ctg ctg cca ggc ctt agg aag ctc agg      716
 Leu Cys Leu Gln Val Thr Asp Leu Leu Pro Gly Leu Arg Lys Leu Arg
                 150                 155                 160

 aac cta ctc cct gag cat gga tgc ctg ctg ctg tcc cct ggg aac ttc      764
 Asn Leu Leu Pro Glu His Gly Cys Leu Leu Leu Ser Pro Gly Asn Phe
             165                 170                 175

 tgg cag aat gac tgg gaa cgc ttc cat gct gat cct gac atc att ggg      812
 Trp Gln Asn Asp Trp Glu Arg Phe His Ala Asp Pro Asp Ile Ile Gly
         180                 185                 190

 acc atc cac cag cac gag cct aaa acc ctg cag act tca gcc aca ctc      860
 Thr Ile His Gln His Glu Pro Lys Thr Leu Gln Thr Ser Ala Thr Leu
     195                 200                 205

 aaa gac ttg tta ttt ggt gtt cct ggg aag tac agc ggg gtg agc ctc      908
 Lys Asp Leu Leu Phe Gly Val Pro Gly Lys Tyr Ser Gly Val Ser Leu
 210                 215                 220                 225

 tac acc agg aag agg atg gtc tcc tac acc atc acc ctg gtc ttc cag      956
 Tyr Thr Arg Lys Arg Met Val Ser Tyr Thr Ile Thr Leu Val Phe Gln
                 230                 235                 240

 cac tac cat gcc aag ttc ctg ggc agc ctg cgt gcc cgc ctg atg ctt     1004
 His Tyr His Ala Lys Phe Leu Gly Ser Leu Arg Ala Arg Leu Met Leu
             245                 250                 255

 ctg cac ccc agc ccc aac tgc agc ctt cgg gcg gag agc ctg gtc cac     1052
 Leu His Pro Ser Pro Asn Cys Ser Leu Arg Ala Glu Ser Leu Val His
         260                 265                 270

 gtg cac ttc aag gag gag att ggt gtc gct gag ctc atc ccc ctt gtg     1100
 Val His Phe Lys Glu Glu Ile Gly Val Ala Glu Leu Ile Pro Leu Val
     275                 280                 285

 acc acc tac atc atc ttg ttt gcc tac atc tac ttc tcc acg cgg aag     1148
 Thr Thr Tyr Ile Ile Leu Phe Ala Tyr Ile Tyr Phe Ser Thr Arg Lys
 290                 295                 300                 305

 atc gac atg gtc aag tcc aag tgg ggg ctg gcc ctg gct gcc gtg gtc     1196
 Ile Asp Met Val Lys Ser Lys Trp Gly Leu Ala Leu Ala Ala Val Val
                 310                 315                 320

 aca gtg ctc agc tcg ctg ctc atg tct gtg gga ctc tgc aca ctc ttc     1244
 Thr Val Leu Ser Ser Leu Leu Met Ser Val Gly Leu Cys Thr Leu Phe
             325                 330                 335

 ggc ctg acg ccc acc ctc aat ggc ggc gag att ttc ccc tac ctt gtg     1292
 Gly Leu Thr Pro Thr Leu Asn Gly Gly Glu Ile Phe Pro Tyr Leu Val
         340                 345                 350

 gtg gtt att ggg tta gag aat gtg ttg gtg ctc acc aag tct gtg gtc     1340
 Val Val Ile Gly Leu Glu Asn Val Leu Val Leu Thr Lys Ser Val Val
     355                 360                 365

 tca acc ccg gta gac ctg gag gtg aag ctg cgg atc gcc caa ggc cta     1388
 Ser Thr Pro Val Asp Leu Glu Val Lys Leu Arg Ile Ala Gln Gly Leu
 370                 375                 380                 385

 agc agc gag agc tgg tcc atc atg aag aac atg gcc acg gag ctg ggc     1436
 Ser Ser Glu Ser Trp Ser Ile Met Lys Asn Met Ala Thr Glu Leu Gly
                 390                 395                 400

 atc atc ctc atc ggc tac ttc acc cta gtg ccc gcc atc cag gag ttc     1484
 Ile Ile Leu Ile Gly Tyr Phe Thr Leu Val Pro Ala Ile Gln Glu Phe
             405                 410                 415

 tgt ctc ttt gct gtc gtg ggg ctg gtg tct gac ttc ttc ctt cag atg     1532
 Cys Leu Phe Ala Val Val Gly Leu Val Ser Asp Phe Phe Leu Gln Met
         420                 425                 430

 ctg ttt ttc acc act gtc ctg tcc att gac att cgc cgg atg gag cta     1580
 Leu Phe Phe Thr Thr Val Leu Ser Ile Asp Ile Arg Arg Met Glu Leu
     435                 440                 445

 gca gac ctg aac aag cga ctg ccc cct gag gcc tgc ctg ccc tca gcc     1628
 Ala Asp Leu Asn Lys Arg Leu Pro Pro Glu Ala Cys Leu Pro Ser Ala
 450                 455                 460                 465

 aag cca gtg ggg cag cca acg cgc tac gag cgg cag ctg gct gtg agg     1676
 Lys Pro Val Gly Gln Pro Thr Arg Tyr Glu Arg Gln Leu Ala Val Arg
                 470                 475                 480

 ccg tcc aca ccc cac acc atc acg ttg cag ccg tct tcc ttc cga aac     1724
 Pro Ser Thr Pro His Thr Ile Thr Leu Gln Pro Ser Ser Phe Arg Asn
             485                 490                 495

 ctg cgg ctc ccc aag agg ctg cgt gtt gtc tac ttc ctg gcc cgc acc     1772
 Leu Arg Leu Pro Lys Arg Leu Arg Val Val Tyr Phe Leu Ala Arg Thr
         500                 505                 510

 cgc ctg gca cag cgc ctc atc atg gct ggc acc gtt gtc tgg att ggc     1820
 Arg Leu Ala Gln Arg Leu Ile Met Ala Gly Thr Val Val Trp Ile Gly
     515                 520                 525

 atc ctg gta tac aca gac cca gca ggg ctg cgc aac tac ctc gct gcc     1868
 Ile Leu Val Tyr Thr Asp Pro Ala Gly Leu Arg Asn Tyr Leu Ala Ala
 530                 535                 540                 545

 cag gtg acg gaa cag agc cca ttg ggt gag gga gcc ctg gct ccc atg     1916
 Gln Val Thr Glu Gln Ser Pro Leu Gly Glu Gly Ala Leu Ala Pro Met
                 550                 555                 560

 ccc gtg cct agt ggc atg ctg ccc ccc agc cac ccg gac cct gcc ttc     1964
 Pro Val Pro Ser Gly Met Leu Pro Pro Ser His Pro Asp Pro Ala Phe
             565                 570                 575

 tcc atc ttc cca cct gat gcc cct aag cta cct gag aac cag acg tcg     2012
 Ser Ile Phe Pro Pro Asp Ala Pro Lys Leu Pro Glu Asn Gln Thr Ser
         580                 585                 590

 cca ggc gag tca cct gag cgt gga ggt cca gca gag gtt gtc cat gac     2060
 Pro Gly Glu Ser Pro Glu Arg Gly Gly Pro Ala Glu Val Val His Asp
     595                 600                 605

 agc cca gtc cca gag gta acc tgg ggg cct gag gat gag gaa ctt tgg     2108
 Ser Pro Val Pro Glu Val Thr Trp Gly Pro Glu Asp Glu Glu Leu Trp
 610                 615                 620                 625

 agg aaa ttg tcc ttc cgc cac tgg ccg acg ctc ttc agc tat tac aac     2156
 Arg Lys Leu Ser Phe Arg His Trp Pro Thr Leu Phe Ser Tyr Tyr Asn
                 630                 635                 640

 atc aca ctg gcc aag agg tac atc agc ctg ctg ccc gtc atc cca gtc     2204
 Ile Thr Leu Ala Lys Arg Tyr Ile Ser Leu Leu Pro Val Ile Pro Val
             645                 650                 655

 acg ctc cgc ctg aac ccg agg gag gct ctg gag ggc cgg cac cct cag     2252
 Thr Leu Arg Leu Asn Pro Arg Glu Ala Leu Glu Gly Arg His Pro Gln
         660                 665                 670

 gac ggc cgc agt gcc tgg ccc cca ccg ggg ccc ata cct gct ggg cac     2300
 Asp Gly Arg Ser Ala Trp Pro Pro Pro Gly Pro Ile Pro Ala Gly His
     675                 680                 685

 tgg gaa gca gga ccc aag ggc cca ggt ggg gtg cag gcc cat gga gac     2348
 Trp Glu Ala Gly Pro Lys Gly Pro Gly Gly Val Gln Ala His Gly Asp
 690                 695                 700                 705

 gtc acg ctg tac aag gtg gcg gcg ctg ggc ctg gcc acc ggc atc gtc     2396
 Val Thr Leu Tyr Lys Val Ala Ala Leu Gly Leu Ala Thr Gly Ile Val
                 710                 715                 720

 ttg gtg ctg ctg ctg ctc tgc ctc tac cgc gtg cta tgc ccg cgc aac     2444
 Leu Val Leu Leu Leu Leu Cys Leu Tyr Arg Val Leu Cys Pro Arg Asn
             725                 730                 735

 tac ggg cag ctg ggt ggt ggg ccc ggg cgg cgg agg cgc ggg gag ctg     2492
 Tyr Gly Gln Leu Gly Gly Gly Pro Gly Arg Arg Arg Arg Gly Glu Leu
         740                 745                 750

 ccc tgc gac gac tac ggc tat gcg cca ccc gag acg gag atc gtg ccg     2540
 Pro Cys Asp Asp Tyr Gly Tyr Ala Pro Pro Glu Thr Glu Ile Val Pro
     755                 760                 765

 ctt gtg ctg cgc ggc cac ctc atg gac atc gag tgc ctg gcc agc gac     2588
 Leu Val Leu Arg Gly His Leu Met Asp Ile Glu Cys Leu Ala Ser Asp
 770                 775                 780                 785

 ggc atg ctg ctg gtg agc tgc tgc ctg gca ggc cac gtc tgc gtg tgg     2636
 Gly Met Leu Leu Val Ser Cys Cys Leu Ala Gly His Val Cys Val Trp
                 790                 795                 800

 gac gcg cag acc ggg gat tgc cta acg cgc att ccg cgc cca ggg cag     2684
 Asp Ala Gln Thr Gly Asp Cys Leu Thr Arg Ile Pro Arg Pro Gly Gln
             805                 810                 815

 cgc cgg gac agt ggc gtg ggc agc ggg ctt gag gct cag gag agc tgg     2732
 Arg Arg Asp Ser Gly Val Gly Ser Gly Leu Glu Ala Gln Glu Ser Trp
         820                 825                 830

 gaa cga ctt tca gat ggt ggg aag gct ggt cca gag gag cct ggg gac     2780
 Glu Arg Leu Ser Asp Gly Gly Lys Ala Gly Pro Glu Glu Pro Gly Asp
     835                 840                 845

 agc cct ccc ctg aga cac cgc ccc cgg ggc cct ccg ccg cct tcc ctc     2828
 Ser Pro Pro Leu Arg His Arg Pro Arg Gly Pro Pro Pro Pro Ser Leu
 850                 855                 860                 865

 ttc ggg gac cag cct gac ctc acc tgc tta att gac acc aac ttt tca     2876
 Phe Gly Asp Gln Pro Asp Leu Thr Cys Leu Ile Asp Thr Asn Phe Ser
                 870                 875                 880

 gcg cag cct cgg tcc tca cag ccc act cag ccc gag ccc cgg cac cgg     2924
 Ala Gln Pro Arg Ser Ser Gln Pro Thr Gln Pro Glu Pro Arg His Arg
             885                 890                 895

 gcg gtc tgt ggc cgc tct cgg gac tcc cca ggc tat gac ttc agc tgc     2972
 Ala Val Cys Gly Arg Ser Arg Asp Ser Pro Gly Tyr Asp Phe Ser Cys
         900                 905                 910

 ctg gtg cag cgg gtg tac cag gag gag ggg ctg gcg gcc gtc tgc aca     3020
 Leu Val Gln Arg Val Tyr Gln Glu Glu Gly Leu Ala Ala Val Cys Thr
     915                 920                 925

 cca gcc ctg cgc cca ccc tcg cct ggg ccg gtg ctg tcc cag gcc cct     3068
 Pro Ala Leu Arg Pro Pro Ser Pro Gly Pro Val Leu Ser Gln Ala Pro
 930                 935                 940                 945

 gag gac gag ggt ggc tcc ccc gag aaa ggc tcc cct tcc ctc gcc tgg     3116
 Glu Asp Glu Gly Gly Ser Pro Glu Lys Gly Ser Pro Ser Leu Ala Trp
                 950                 955                 960

 gcc ccc agt gcc gag ggt tcc atc tgg agc ttg gag ctg cag ggc aac     3164
 Ala Pro Ser Ala Glu Gly Ser Ile Trp Ser Leu Glu Leu Gln Gly Asn
             965                 970                 975

 ctc atc gtg gtg ggg cgg agc agc ggc cgg ctg gag gtg tgg gac gcc     3212
 Leu Ile Val Val Gly Arg Ser Ser Gly Arg Leu Glu Val Trp Asp Ala
         980                 985                 990

 att gaa ggg gtg ctg tgc tgc agc agc gag gag gtc tcc tca ggc att     3260
 Ile Glu Gly Val Leu Cys Cys Ser Ser Glu Glu Val Ser Ser Gly Ile
     995                1000                1005

 acc gct ctg gtg ttc ttg gac aaa agg att gtg gct gca cgg ctc aac     3308
 Thr Ala Leu Val Phe Leu Asp Lys Arg Ile Val Ala Ala Arg Leu Asn
1010                1015                1020                1025

 ggt tcc ctt gat ttc ttc tcc ttg gag acc cac act gcc ctc agc ccc     3356
 Gly Ser Leu Asp Phe Phe Ser Leu Glu Thr His Thr Ala Leu Ser Pro
                1030                1035                1040

 ctg cag ttt aga ggg acc cca ggg cgg ggc agt tcc cct gcc tct cca     3404
 Leu Gln Phe Arg Gly Thr Pro Gly Arg Gly Ser Ser Pro Ala Ser Pro
            1045                1050                1055

 gtg tac agc agc agc gac aca gtg gcc tgt cac ctg acc cac aca gtg     3452
 Val Tyr Ser Ser Ser Asp Thr Val Ala Cys His Leu Thr His Thr Val
        1060                1065                1070

 ccc tgt gca cac caa aaa ccc atc aca gcc ctg aaa gcc gct gct ggg     3500
 Pro Cys Ala His Gln Lys Pro Ile Thr Ala Leu Lys Ala Ala Ala Gly
    1075                1080                1085

 cgc ttg gtg act ggg agc caa gac cac aca ctg aga gtg ttc cgt ctg     3548
 Arg Leu Val Thr Gly Ser Gln Asp His Thr Leu Arg Val Phe Arg Leu
1090                1095                1100                1105

 gag gac tcg tgc tgc ctc ttc acc ctt cag ggc cac tca ggg gcc atc     3596
 Glu Asp Ser Cys Cys Leu Phe Thr Leu Gln Gly His Ser Gly Ala Ile
                1110                1115                1120

 acg acc gtg tac att gac cag acc atg gtg ctg gcc agt gga gga caa     3644
 Thr Thr Val Tyr Ile Asp Gln Thr Met Val Leu Ala Ser Gly Gly Gln
            1125                1130                1135

 gat ggg gcc atc tgc ctg tgg gat gta ctg act ggc agc cgg gtc agc     3692
 Asp Gly Ala Ile Cys Leu Trp Asp Val Leu Thr Gly Ser Arg Val Ser
        1140                1145                1150

 cat gtg ttt gct cac cgt ggg gat gtc acc tcc ctt acc tgt acc acc     3740
 His Val Phe Ala His Arg Gly Asp Val Thr Ser Leu Thr Cys Thr Thr
    1155                1160                1165

 tcc tgt gtc atc agc agt ggc ctg gat gac ctc atc agc atc tgg gac     3788
 Ser Cys Val Ile Ser Ser Gly Leu Asp Asp Leu Ile Ser Ile Trp Asp
1170                1175                1180                1185

 cgc agc aca ggc atc aag ttc tac tcc att cag cag gac ctg ggc tgt     3836
 Arg Ser Thr Gly Ile Lys Phe Tyr Ser Ile Gln Gln Asp Leu Gly Cys
                1190                1195                1200

 ggt gca agc ttg ggt gtc atc tca aac aac ctg ctg gtg act ggc ggc     3884
 Gly Ala Ser Leu Gly Val Ile Ser Asn Asn Leu Leu Val Thr Gly Gly
            1205                1210                1215

 cag ggc tgt gtc tcc ttt tgg gac cta aac tac ggg gac ctg tta cag     3932
 Gln Gly Cys Val Ser Phe Trp Asp Leu Asn Tyr Gly Asp Leu Leu Gln
        1220                1225                1230

 aca gtc tac ctg ggg aag aac agt gag gcc cag cct gcc cgc cag atc     3980
 Thr Val Tyr Leu Gly Lys Asn Ser Glu Ala Gln Pro Ala Arg Gln Ile
    1235                1240                1245

 ctg gtg ctg gac aac gct gcc att gtc tgc aac ttt ggc agt gag ctc     4028
 Leu Val Leu Asp Asn Ala Ala Ile Val Cys Asn Phe Gly Ser Glu Leu
1250                1255                1260                1265

 agc ctg gtg tat gtg ccc tct gtg ctg gag aag ctg gac tga gcgcagg     4077
 Ser Leu Val Tyr Val Pro Ser Val Leu Glu Lys Leu Asp 
                1270                1275

 gcctccttgc ccaggcagga ggctggggtg ctgtgtgggg gccaatgcac tgaacctgga   4137

 cttgggggaa agagccgagt atcttccagc cgctgcctcc tgactgtaat aatattaaac   4197

 ttttttaaaa aaccataaaa aaaaaaaaaa agggggggcc gttttaaagg atccctgggg   4257

 gggcccaagt ttacgcgggc atggagagga ttagtttttt ccctataggg ggcgaattat   4317

 aacctaggcc ctggccggct ttt                                           4340




      <210> 320
      <211> 1793
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (192)..(1337)

      <400> 320
 agcggccgcc gcgcgccagc gggaggcgct ccctctgccc acctccgccc cctgcggacc     60

 gagacccgga gatgtcgagt tgtggagttc ggctcggccc ggcgacgggc tagctgcccg    120

 ggaacccccg cgggtggaca catgcatgcc ggagctccgg gaggggccgc gccgccaccg    180

 tctgaactag g atg tcc cga cat gaa ggt gtc agc tgt gat gca tgt tta     230
              Met Ser Arg His Glu Gly Val Ser Cys Asp Ala Cys Leu
                1               5                  10

 aaa gga aat ttt cga ggt cgc aga tat aag tgt tta att tgc tac gat      278
 Lys Gly Asn Phe Arg Gly Arg Arg Tyr Lys Cys Leu Ile Cys Tyr Asp
      15                  20                  25

 tac gat ctt tgt gca tct tgt tat gaa agt ggt gca aca aca aca agg      326
 Tyr Asp Leu Cys Ala Ser Cys Tyr Glu Ser Gly Ala Thr Thr Thr Arg
  30                  35                  40                  45

 cat aca act gac cac cca atg cag tgc ata tta aca agg gta gat ttt      374
 His Thr Thr Asp His Pro Met Gln Cys Ile Leu Thr Arg Val Asp Phe
                  50                  55                  60

 gat tta tac tat ggt ggg gaa gct ttc tct gta gag cag cca cag tct      422
 Asp Leu Tyr Tyr Gly Gly Glu Ala Phe Ser Val Glu Gln Pro Gln Ser
              65                  70                  75

 ttt act tgt ccc tat tgt gga aaa atg ggc tat acg gag aca tct ctt      470
 Phe Thr Cys Pro Tyr Cys Gly Lys Met Gly Tyr Thr Glu Thr Ser Leu
          80                  85                  90

 caa gaa cat gtt act tct gaa cat gca gaa aca tca aca gaa gtg att      518
 Gln Glu His Val Thr Ser Glu His Ala Glu Thr Ser Thr Glu Val Ile
      95                 100                 105

 tgt cca ata tgt gca gcg tta cct gga ggc gat cct aat cat gtc acg      566
 Cys Pro Ile Cys Ala Ala Leu Pro Gly Gly Asp Pro Asn His Val Thr
 110                 115                 120                 125

 gat gac ttt gca gct cat ctt aca ctt gaa cac aga gcc cct aga gat      614
 Asp Asp Phe Ala Ala His Leu Thr Leu Glu His Arg Ala Pro Arg Asp
                 130                 135                 140

 tta gat gaa tcg agt ggt gtt cga cat gta cgt aga atg ttt cac cct      662
 Leu Asp Glu Ser Ser Gly Val Arg His Val Arg Arg Met Phe His Pro
             145                 150                 155

 ggc cgg gga tta gga ggt cct cgt gct cgt aga tca aac atg cac ttt      710
 Gly Arg Gly Leu Gly Gly Pro Arg Ala Arg Arg Ser Asn Met His Phe
         160                 165                 170

 act agc agt tct act ggt gga ctt tct tct tct cag agt tca tat tct      758
 Thr Ser Ser Ser Thr Gly Gly Leu Ser Ser Ser Gln Ser Ser Tyr Ser
     175                 180                 185

 cca agc aat agg gaa gcc atg gat cct ata gct gag ctt tta tct cag      806
 Pro Ser Asn Arg Glu Ala Met Asp Pro Ile Ala Glu Leu Leu Ser Gln
 190                 195                 200                 205

 tta tca gga gtg aga cgt tct gca gga gga cag ctt aat tcc tct ggc      854
 Leu Ser Gly Val Arg Arg Ser Ala Gly Gly Gln Leu Asn Ser Ser Gly
                 210                 215                 220

 cct tcc gct tct cag tta caa caa ctg cag atg cag ctg cag cta gaa      902
 Pro Ser Ala Ser Gln Leu Gln Gln Leu Gln Met Gln Leu Gln Leu Glu
             225                 230                 235

 cgg cag cat gcc cag gca gca cgg caa caa ctg gag acc gca cgc aac      950
 Arg Gln His Ala Gln Ala Ala Arg Gln Gln Leu Glu Thr Ala Arg Asn
         240                 245                 250

 gca acc cgg cgt act aac aca agc agt gtc acc act aca atc aca caa      998
 Ala Thr Arg Arg Thr Asn Thr Ser Ser Val Thr Thr Thr Ile Thr Gln
     255                 260                 265

 tcc aca gca aca acc aac ata gct aat aca gaa agc agt cag cag act     1046
 Ser Thr Ala Thr Thr Asn Ile Ala Asn Thr Glu Ser Ser Gln Gln Thr
 270                 275                 280                 285

 cta cag aat tcc cag ttt ctt tta aca agg ttg aat gat cct aaa atg     1094
 Leu Gln Asn Ser Gln Phe Leu Leu Thr Arg Leu Asn Asp Pro Lys Met
                 290                 295                 300

 tct gaa acg gag cgc cag tcc atg gaa agc gag cgt gca gac cgc agc     1142
 Ser Glu Thr Glu Arg Gln Ser Met Glu Ser Glu Arg Ala Asp Arg Ser
             305                 310                 315

 ctg ttt gtc caa gag ctc ctt ctg tcc act tta gtg cgt gaa gag agc     1190
 Leu Phe Val Gln Glu Leu Leu Leu Ser Thr Leu Val Arg Glu Glu Ser
         320                 325                 330

 tca tcc tca gat gag gat gat cgg ggg gag atg gca gat ttt ggt gct     1238
 Ser Ser Ser Asp Glu Asp Asp Arg Gly Glu Met Ala Asp Phe Gly Ala
     335                 340                 345

 atg ggc tgt gta gat att atg cct tta gat gtt gct tta gaa aac cta     1286
 Met Gly Cys Val Asp Ile Met Pro Leu Asp Val Ala Leu Glu Asn Leu
 350                 355                 360                 365

 aat tta aaa gag agt aat aaa gga aat gag cct cca cca cct cct ctt     1334
 Asn Leu Lys Glu Ser Asn Lys Gly Asn Glu Pro Pro Pro Pro Pro Leu
                 370                 375                 380

 tga tgac atcccaattc gcagacaatg tcctctgtgc tgtatttgcc aatgaaagtg     1391
 


 gacaacaact atcttgggtt tgtttggtga ttgtaatttc aggtctgtca ctcttgttac   1451

 attgtgtaca ttcaaaagga agagagaaaa tatatatgat aatcatttcc acttaactaa   1511

 tttttacttc tagcaggtaa atgtaggtag cagtgcaggg gtgatctctg cttcctgtac   1571

 cttgacatgc aaaaggctct cctaatactc cacattcaaa ctgaagagga aaattgaaat   1631

 ctctaatgaa gctgctgtgt gtatttatga atattaatga ataaaaactg cgtcgacgcg   1691

 gccgcgaatt cggatcctcg agagatctct ttttttgggt ttggtggggt atcttcatca   1751

 tcgaatagat agtgtatata cgtcacgctt ctcgatgtca ag                      1793




      <210> 321
      <211> 1297
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (227)..(814)

      <400> 321
 ggggagcgcg ggctgcggag aggcgggccg ggccaagcgg agccgagcga gcgggagcgc     60

 ggcgtccggg aggcggcgga gacgcggggc tcggagggtc agcctcttat cgtagcaggt    120

 ctcctcggca cgcccccctt gtttcgcccc acggccaagc ccgccgcggg ccggcgtgcg    180

 ctggtcactg aggcccaggt cgccgccgcg gcgcgttttt gaaatc   atg aat cct     235
                                                      Met Asn Pro
                                                        1

 gtt tat agt cct gga tct tct ggg gtt ccc tat gca aat gcc aaa gga      283
 Val Tyr Ser Pro Gly Ser Ser Gly Val Pro Tyr Ala Asn Ala Lys Gly
       5                  10                  15

 att ggt tat cca gct ggt ttt ccc atg ggc tat gca gca gca gct cct      331
 Ile Gly Tyr Pro Ala Gly Phe Pro Met Gly Tyr Ala Ala Ala Ala Pro
  20                  25                  30                  35

 gcc tat tct cct aac atg tat cct gga gcg aat cct acc ttc caa aca      379
 Ala Tyr Ser Pro Asn Met Tyr Pro Gly Ala Asn Pro Thr Phe Gln Thr
                  40                  45                  50

 ggt tac act cct ggc aca cct tac aaa gtg tcc tgt tcc ccc acc agc      427
 Gly Tyr Thr Pro Gly Thr Pro Tyr Lys Val Ser Cys Ser Pro Thr Ser
              55                  60                  65

 ggg gct gtg cca ccg tac tcc tcc tcc ccg aac ccc tac cag act gcc      475
 Gly Ala Val Pro Pro Tyr Ser Ser Ser Pro Asn Pro Tyr Gln Thr Ala
          70                  75                  80

 gtg tac cct gtg cga agt gcc tac ccc cag cag agc ccg tat gca cag      523
 Val Tyr Pro Val Arg Ser Ala Tyr Pro Gln Gln Ser Pro Tyr Ala Gln
      85                  90                  95

 caa ggc acg tac tac aca cag ccg ctg tat gca gca cct cct cac gtc      571
 Gln Gly Thr Tyr Tyr Thr Gln Pro Leu Tyr Ala Ala Pro Pro His Val
 100                 105                 110                 115

 atc cac cac acc acg gtg gtg cag ccc aac ggc atg cct gca acg gtg      619
 Ile His His Thr Thr Val Val Gln Pro Asn Gly Met Pro Ala Thr Val
                 120                 125                 130

 tac cct gct ccc atc ccc cct cct aga ggc aac ggg gtc acc atg ggc      667
 Tyr Pro Ala Pro Ile Pro Pro Pro Arg Gly Asn Gly Val Thr Met Gly
             135                 140                 145

 atg gtg gct ggg acc acc atg gcc atg tca gca ggt acc ctg ctg act      715
 Met Val Ala Gly Thr Thr Met Ala Met Ser Ala Gly Thr Leu Leu Thr
         150                 155                 160

 gct cac tcc cca act cct gtc gcc ccc cac ccg gtc act gtg ccc acg      763
 Ala His Ser Pro Thr Pro Val Ala Pro His Pro Val Thr Val Pro Thr
     165                 170                 175

 tac cgg gcc cca gga acg ccc act tac agc tat gtg ccc cct cag tgg      811
 Tyr Arg Ala Pro Gly Thr Pro Thr Tyr Ser Tyr Val Pro Pro Gln Trp
 180                 185                 190                 195

 tga tcac ctgcaaatgt ttgaggacgg agctgtgcag tcacattatt ggggattcca      868
 


 cagctggtgc tgcaggcctt gcgcctccaa ccaggacttt cttcttaatg ctctcgacac    928

 ttagctaaac acgactatat cccggcccag caggccccag cgccgttagt ctccagctga    988

 ctctgtgggt tggtcttaaa gcaaattctg ttttgtggac tgcctggcaa ttttttagct   1048

 aactgtaatg ataaaaaggg agtattaatc tattctgaat catatctagt tgaatgcatg   1108

 tttaaaaaaa aaaaaaaaaa aaccttgctc aatctacctg cagtgactga tgcaaaacca   1168

 tcatatgcaa aatccaaagg aatggaaacg tattttacaa cttgtatcac taatgcactg   1228

 ttgtaatgta tgcaaagtct tacagttata agtgttaaag tgaatttctt catagagcaa   1288

 aaaaaaaaa                                                           1297




      <210> 322
      <211> 1740
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(1393)

      <400> 322
 ggcggcggga gagctgctgg ctcgcccgga tcccgggagc tgcctggagg cgggcccggc     60

 ccggggaagg tgagcggctg cgggacccag cccctcgccg ggagcgggca cc    atg     115
                                                              Met
                                                                1

 gtg ctg tcg gtg cct gtg atc gcg ctg ggc gcc acg ctg ggc aca gcc      163
 Val Leu Ser Val Pro Val Ile Ala Leu Gly Ala Thr Leu Gly Thr Ala
               5                  10                  15

 acc agc atc ctc gcg ttg tgc ggg gtc acc tgc ctg tgt cgg cac atg      211
 Thr Ser Ile Leu Ala Leu Cys Gly Val Thr Cys Leu Cys Arg His Met
          20                  25                  30

 cac ccc aag aag ggg ctg ctg ccg cgg gac cag gac ccc gac ctg gag      259
 His Pro Lys Lys Gly Leu Leu Pro Arg Asp Gln Asp Pro Asp Leu Glu
      35                  40                  45

 aag gcg aag ccc agc ttg ctc ggg tct gca caa cag ttc aat gtt aaa      307
 Lys Ala Lys Pro Ser Leu Leu Gly Ser Ala Gln Gln Phe Asn Val Lys
  50                  55                  60                  65

 aag tcc acg gaa cct gtt cag ccc cgt gcc ctc ctc aag ttc cca gac      355
 Lys Ser Thr Glu Pro Val Gln Pro Arg Ala Leu Leu Lys Phe Pro Asp
                  70                  75                  80

 atc tat gga ccc agg cca gct gtg acg gct cca gag gtc atc aac tat      403
 Ile Tyr Gly Pro Arg Pro Ala Val Thr Ala Pro Glu Val Ile Asn Tyr
              85                  90                  95

 gca gac tat tca ctg agg tct acg gag gag ccc act gca cct gcc agc      451
 Ala Asp Tyr Ser Leu Arg Ser Thr Glu Glu Pro Thr Ala Pro Ala Ser
         100                 105                 110

 ccc caa ccc ccg aat gac agt cgc ctc aag agg cag gtc aca gag gag      499
 Pro Gln Pro Pro Asn Asp Ser Arg Leu Lys Arg Gln Val Thr Glu Glu
     115                 120                 125

 ctg ttc atc ctc cct cag aat ggt gtg gtg gag gat gtc tgt gtc atg      547
 Leu Phe Ile Leu Pro Gln Asn Gly Val Val Glu Asp Val Cys Val Met
 130                 135                 140                 145

 gag acc tgg aac cca gag aag gct gcc agt tgg aac cag gcc ccc aaa      595
 Glu Thr Trp Asn Pro Glu Lys Ala Ala Ser Trp Asn Gln Ala Pro Lys
                 150                 155                 160

 ctc cac tac tgc ctg gac tat gac tgt cag aag gca gaa ttg ttt gtg      643
 Leu His Tyr Cys Leu Asp Tyr Asp Cys Gln Lys Ala Glu Leu Phe Val
             165                 170                 175

 act cgc ctg gaa gct gtg acc agc aac cac gac gga ggc tgt gac tgc      691
 Thr Arg Leu Glu Ala Val Thr Ser Asn His Asp Gly Gly Cys Asp Cys
         180                 185                 190

 tac gtc caa ggg agt gtg gcc aat agg acc ggc tct gtg gag gct cag      739
 Tyr Val Gln Gly Ser Val Ala Asn Arg Thr Gly Ser Val Glu Ala Gln
     195                 200                 205

 aca gcc cta aag aag cgg cag ctg cac acc acc tgg gag gag ggc ctg      787
 Thr Ala Leu Lys Lys Arg Gln Leu His Thr Thr Trp Glu Glu Gly Leu
 210                 215                 220                 225

 gtg ctc ccc ctg gcg gag gag gag ctc ccc aca gcc acc ctg acg ctg      835
 Val Leu Pro Leu Ala Glu Glu Glu Leu Pro Thr Ala Thr Leu Thr Leu
                 230                 235                 240

 acc ttg agg acc tgc gac cgc ttc tcc cgt cac agc gtg gcc ggg gag      883
 Thr Leu Arg Thr Cys Asp Arg Phe Ser Arg His Ser Val Ala Gly Glu
             245                 250                 255

 ctc cgc ctg ggc ctg gac ggg aca tct gtg cct cta ggg gct gcc cag      931
 Leu Arg Leu Gly Leu Asp Gly Thr Ser Val Pro Leu Gly Ala Ala Gln
         260                 265                 270

 tgg ggc gag ctg aag act tca gcg aag gag cca tct gca gga gct gga      979
 Trp Gly Glu Leu Lys Thr Ser Ala Lys Glu Pro Ser Ala Gly Ala Gly
     275                 280                 285

 gag gtc cta cta tcc atc agc tac ctc ccg gct gcc aac cgc ctc ctg     1027
 Glu Val Leu Leu Ser Ile Ser Tyr Leu Pro Ala Ala Asn Arg Leu Leu
 290                 295                 300                 305

 gtg gtg ctg att aaa gcc aag aac ctc cac tct aac cag tcc aag gag     1075
 Val Val Leu Ile Lys Ala Lys Asn Leu His Ser Asn Gln Ser Lys Glu
                 310                 315                 320

 ctc ctg ggg aag gat gtc tct gtc aag gtg acc ttg aag cac cag gct     1123
 Leu Leu Gly Lys Asp Val Ser Val Lys Val Thr Leu Lys His Gln Ala
             325                 330                 335

 cgg aag ctg aag aag aag cag act aaa cga gct aag cac aag atc aac     1171
 Arg Lys Leu Lys Lys Lys Gln Thr Lys Arg Ala Lys His Lys Ile Asn
         340                 345                 350

 ccc gtg tgg aac gag atg atc atg ttt gag ctg cct gac gac ctg ctg     1219
 Pro Val Trp Asn Glu Met Ile Met Phe Glu Leu Pro Asp Asp Leu Leu
     355                 360                 365

 cag gcc tcc agt gtg gag ctg gaa gtg ctg ggc cag gac gat tca ggg     1267
 Gln Ala Ser Ser Val Glu Leu Glu Val Leu Gly Gln Asp Asp Ser Gly
 370                 375                 380                 385

 cag agc tgt gcg ctt ggc cac tgc agc ctg ggc ctg cac acc tcg ggc     1315
 Gln Ser Cys Ala Leu Gly His Cys Ser Leu Gly Leu His Thr Ser Gly
                 390                 395                 400

 tct gag cgc agc cac tgg gag gag atg ctc aaa aac cct cgc cgg cag     1363
 Ser Glu Arg Ser His Trp Glu Glu Met Leu Lys Asn Pro Arg Arg Gln
             405                 410                 415

 att gcc atg tgg cac cag ctg cac ctg taa c cagctgccca gctgcctccc     1414
 Ile Ala Met Trp His Gln Leu His Leu 
         420                 425

 ttcttggaca gccctgaccc gtcctctgca acctcctttc tgtgcccctt tcctcattct   1474

 gacacccaga agacagtgac agatgtgttt gcaaggctgg gatggctctc tcatcatact   1534

 cttgtttctt agaaataagc aagacagagc aggaaatgga atatgcgggt cacactgagg   1594

 aatgcatttt gctcatctgt gttattgaag gaggtgctta ttaaatacag ttcctatgcc   1654

 tgttttatag gtggggttag gccagatgca gagaaagcta aatgtgggaa tcatggatgc   1714

 aaagaagaat ttggcttttt gaaaaa                                        1740




      <210> 323
      <211> 6210
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (155)..(3271)

      <400> 323
 aaggatcctt aattaaatta atcccccccc cccccgctct ttcctttcgc gccggttgcc     60

 gctgcggagc gcggcgggtc catgtgcgca gtgagtggcg ctattcctgg cccagtagca    120

 cccgagcccc gggtttgacc gagtccgcgc tgcg    atg gac ccc aac acc att     172
                                          Met Asp Pro Asn Thr Ile
                                            1               5

 atc gag gcc ctg cgg ggc acc atg gac cca gcc ctg cgt gag gcc gcg      220
 Ile Glu Ala Leu Arg Gly Thr Met Asp Pro Ala Leu Arg Glu Ala Ala
              10                  15                  20

 gag cgc cag ctc aat gaa gca cac aag tct ctg aat ttt gtc tca aca      268
 Glu Arg Gln Leu Asn Glu Ala His Lys Ser Leu Asn Phe Val Ser Thr
          25                  30                  35

 ctg ctc cag att act atg tcg gaa cag ctg gat tta cct gtg aga cag      316
 Leu Leu Gln Ile Thr Met Ser Glu Gln Leu Asp Leu Pro Val Arg Gln
      40                  45                  50

 gca ggt gtt atc tat ctg aaa aat atg ata aca cag tat tgg cct gat      364
 Ala Gly Val Ile Tyr Leu Lys Asn Met Ile Thr Gln Tyr Trp Pro Asp
  55                  60                  65                  70

 cga gaa aca gca cca ggg gat ata tcc cct tat act att cca gaa gaa      412
 Arg Glu Thr Ala Pro Gly Asp Ile Ser Pro Tyr Thr Ile Pro Glu Glu
                  75                  80                  85

 gat cgc cat tgt att cga gaa aat att gta gaa gcc att atc cat tct      460
 Asp Arg His Cys Ile Arg Glu Asn Ile Val Glu Ala Ile Ile His Ser
              90                  95                 100

 cct gag ctc atc agg gta cag ctt act aca tgc att cat cac atc atc      508
 Pro Glu Leu Ile Arg Val Gln Leu Thr Thr Cys Ile His His Ile Ile
         105                 110                 115

 aaa cat gat tat cca agc cgc tgg act gcc att gtg gac aaa att ggc      556
 Lys His Asp Tyr Pro Ser Arg Trp Thr Ala Ile Val Asp Lys Ile Gly
     120                 125                 130

 ttt tat ctt cag tcc gat aac agt gct tgt tgg cta gga att ctt ctt      604
 Phe Tyr Leu Gln Ser Asp Asn Ser Ala Cys Trp Leu Gly Ile Leu Leu
 135                 140                 145                 150

 tgc ctt tat cag ctt gtg aaa aat tat gag tat aaa aaa cca gag gag      652
 Cys Leu Tyr Gln Leu Val Lys Asn Tyr Glu Tyr Lys Lys Pro Glu Glu
                 155                 160                 165

 cgg agt cca ttg gta gca gca atg cag cat ttt ctg cca gtt cta aag      700
 Arg Ser Pro Leu Val Ala Ala Met Gln His Phe Leu Pro Val Leu Lys
             170                 175                 180

 gat cgt ttt atc cag ctt ctt tct gac cag tct gat cag tct gtc ctc      748
 Asp Arg Phe Ile Gln Leu Leu Ser Asp Gln Ser Asp Gln Ser Val Leu
         185                 190                 195

 atc cag aaa cag ata ttc aag atc ttc tat gct ctt gtt cag tat aca      796
 Ile Gln Lys Gln Ile Phe Lys Ile Phe Tyr Ala Leu Val Gln Tyr Thr
     200                 205                 210

 cta cca ctg gaa ctg ata aac caa cag aac ctg aca gaa tgg ata gaa      844
 Leu Pro Leu Glu Leu Ile Asn Gln Gln Asn Leu Thr Glu Trp Ile Glu
 215                 220                 225                 230

 att tta aag act gtt gtg aac agg gat gta cct aat gaa aca ctt caa      892
 Ile Leu Lys Thr Val Val Asn Arg Asp Val Pro Asn Glu Thr Leu Gln
                 235                 240                 245

 gtt gaa gaa gat gat cga cct gag tta cca tgg tgg aaa tgc aag aag      940
 Val Glu Glu Asp Asp Arg Pro Glu Leu Pro Trp Trp Lys Cys Lys Lys
             250                 255                 260

 tgg gcc tta cat att tta gca aga ctt ttt gaa aga tat gga agc cct      988
 Trp Ala Leu His Ile Leu Ala Arg Leu Phe Glu Arg Tyr Gly Ser Pro
         265                 270                 275

 ggc aat gtt tcc aag gag tat aat gaa ttt gct gaa gta ttt ctg aag     1036
 Gly Asn Val Ser Lys Glu Tyr Asn Glu Phe Ala Glu Val Phe Leu Lys
     280                 285                 290

 gca ttt gct gtt ggt gtc cag caa gtt tta ttg aag gtg tta tat cag     1084
 Ala Phe Ala Val Gly Val Gln Gln Val Leu Leu Lys Val Leu Tyr Gln
 295                 300                 305                 310

 tac aag gag aag caa tat atg gct cct cga gtt tta caa cag aca tta     1132
 Tyr Lys Glu Lys Gln Tyr Met Ala Pro Arg Val Leu Gln Gln Thr Leu
                 315                 320                 325

 aat tat att aat caa gga gtt tct cat gct ctc acc tgg aag aat ctg     1180
 Asn Tyr Ile Asn Gln Gly Val Ser His Ala Leu Thr Trp Lys Asn Leu
             330                 335                 340

 aag ccc cat ata caa ggc att atc caa gat gtt att ttt cca ttg atg     1228
 Lys Pro His Ile Gln Gly Ile Ile Gln Asp Val Ile Phe Pro Leu Met
         345                 350                 355

 tgc tat aca gat gct gat gag gaa ctt tgg caa gaa gac cct tac gaa     1276
 Cys Tyr Thr Asp Ala Asp Glu Glu Leu Trp Gln Glu Asp Pro Tyr Glu
     360                 365                 370

 tat ata cgc atg aag ttt gat gtg ttt gaa gat ttc att tct cct acc     1324
 Tyr Ile Arg Met Lys Phe Asp Val Phe Glu Asp Phe Ile Ser Pro Thr
 375                 380                 385                 390

 act gct gcc cag aca ctt ttg ttt aca gcc tgt agt aag agg aaa gag     1372
 Thr Ala Ala Gln Thr Leu Leu Phe Thr Ala Cys Ser Lys Arg Lys Glu
                 395                 400                 405

 gta ctg caa aag act atg gga ttt tgt tac cag att ctt aca gaa cca     1420
 Val Leu Gln Lys Thr Met Gly Phe Cys Tyr Gln Ile Leu Thr Glu Pro
             410                 415                 420

 aat gct gac cct cga aaa aaa gat gga gcc ctg cat atg att ggc tct     1468
 Asn Ala Asp Pro Arg Lys Lys Asp Gly Ala Leu His Met Ile Gly Ser
         425                 430                 435

 tta gct gaa ata ctt ctg aag aaa aag atc tat aaa gat cag atg gaa     1516
 Leu Ala Glu Ile Leu Leu Lys Lys Lys Ile Tyr Lys Asp Gln Met Glu
     440                 445                 450

 tac atg ttg cag aat cat gta ttc cct ctc ttc agc agt gaa cta ggc     1564
 Tyr Met Leu Gln Asn His Val Phe Pro Leu Phe Ser Ser Glu Leu Gly
 455                 460                 465                 470

 tac atg aga gca agg gct tgc tgg gta ctt cac tat ttt tgt gaa gtg     1612
 Tyr Met Arg Ala Arg Ala Cys Trp Val Leu His Tyr Phe Cys Glu Val
                 475                 480                 485

 aag ttc aaa agt gat cag aac ctt caa aca gcc tta gag cta aca aga     1660
 Lys Phe Lys Ser Asp Gln Asn Leu Gln Thr Ala Leu Glu Leu Thr Arg
             490                 495                 500

 aga tgt ctg att gat gat aga gaa atg cct gtg aaa gtg gaa gct gcc     1708
 Arg Cys Leu Ile Asp Asp Arg Glu Met Pro Val Lys Val Glu Ala Ala
         505                 510                 515

 att gcc ctt caa gta ttg atc agc aat caa gaa aaa gct aaa gaa tat     1756
 Ile Ala Leu Gln Val Leu Ile Ser Asn Gln Glu Lys Ala Lys Glu Tyr
     520                 525                 530

 atc aca cca ttc atc aga cct gta atg cag gct ctt ctt cac att ata     1804
 Ile Thr Pro Phe Ile Arg Pro Val Met Gln Ala Leu Leu His Ile Ile
 535                 540                 545                 550

 aga gaa aca gaa aat gat gac ctt acc aat gta att cag aaa atg atc     1852
 Arg Glu Thr Glu Asn Asp Asp Leu Thr Asn Val Ile Gln Lys Met Ile
                 555                 560                 565

 tgt gaa tat agt gaa gaa gtt act cct att gca gta gaa atg aca caa     1900
 Cys Glu Tyr Ser Glu Glu Val Thr Pro Ile Ala Val Glu Met Thr Gln
             570                 575                 580

 cat ttg gca atg aca ttt aac caa gta atc cag acg ggg cca gat gaa     1948
 His Leu Ala Met Thr Phe Asn Gln Val Ile Gln Thr Gly Pro Asp Glu
         585                 590                 595

 gaa ggt agt gat gac aaa gca gtt act gct atg gga att ctg aat aca     1996
 Glu Gly Ser Asp Asp Lys Ala Val Thr Ala Met Gly Ile Leu Asn Thr
     600                 605                 610

 att gat aca ctt ctt agt gta gtt gaa gat cat aaa gag ata acc caa     2044
 Ile Asp Thr Leu Leu Ser Val Val Glu Asp His Lys Glu Ile Thr Gln
 615                 620                 625                 630

 cag ctt gag gga atc tgc tta cag gtc att ggt act gtt tta caa cag     2092
 Gln Leu Glu Gly Ile Cys Leu Gln Val Ile Gly Thr Val Leu Gln Gln
                 635                 640                 645

 cat gtc tta gaa ttc tat gag gag atc ttc tct tta gcg cac agt ttg     2140
 His Val Leu Glu Phe Tyr Glu Glu Ile Phe Ser Leu Ala His Ser Leu
             650                 655                 660

 aca tgt caa caa gtg tct cca cag atg tgg cag cta cta ccc ctt gta     2188
 Thr Cys Gln Gln Val Ser Pro Gln Met Trp Gln Leu Leu Pro Leu Val
         665                 670                 675

 ttt gaa gtc ttt cag caa gat ggc ttt gat tac ttt aca gat atg atg     2236
 Phe Glu Val Phe Gln Gln Asp Gly Phe Asp Tyr Phe Thr Asp Met Met
     680                 685                 690

 ccc ctc ctt cat aat tat gta aca gtt gat aca gac aca ctt ctg tct     2284
 Pro Leu Leu His Asn Tyr Val Thr Val Asp Thr Asp Thr Leu Leu Ser
 695                 700                 705                 710

 gac acc aag tat ctt gaa atg ata tac agt atg tgc aaa aag gtt ctt     2332
 Asp Thr Lys Tyr Leu Glu Met Ile Tyr Ser Met Cys Lys Lys Val Leu
                 715                 720                 725

 aca gga gtt gca gga gaa gat gca gag tgt cat gca gca aaa ttg tta     2380
 Thr Gly Val Ala Gly Glu Asp Ala Glu Cys His Ala Ala Lys Leu Leu
             730                 735                 740

 gag gtc atc att ctg cag tgc aaa ggg cgt ggc att gac cag tgc att     2428
 Glu Val Ile Ile Leu Gln Cys Lys Gly Arg Gly Ile Asp Gln Cys Ile
         745                 750                 755

 ccc tta ttc gtg gaa gca gcc tta gaa aga ctg aca aga gag gtt aag     2476
 Pro Leu Phe Val Glu Ala Ala Leu Glu Arg Leu Thr Arg Glu Val Lys
     760                 765                 770

 aca agt gaa ctt cga act atg tgt ctg caa gtt gca att gca gct ttg     2524
 Thr Ser Glu Leu Arg Thr Met Cys Leu Gln Val Ala Ile Ala Ala Leu
 775                 780                 785                 790

 tat tat aat cca cac cta cta ctc aat acc tta gaa aat ctt cgc ttc     2572
 Tyr Tyr Asn Pro His Leu Leu Leu Asn Thr Leu Glu Asn Leu Arg Phe
                 795                 800                 805

 cct aat aat gtt gaa cca gtt aca aat cat ttt att aca cag tgg ctt     2620
 Pro Asn Asn Val Glu Pro Val Thr Asn His Phe Ile Thr Gln Trp Leu
             810                 815                 820

 aat gat gtt gac tgt ttc ttg ggg ctt cat gac aga aag atg tgt gtt     2668
 Asn Asp Val Asp Cys Phe Leu Gly Leu His Asp Arg Lys Met Cys Val
         825                 830                 835

 ctc gga ctc tgt gct ctt att gat atg gaa cag ata ccc caa gtt tta     2716
 Leu Gly Leu Cys Ala Leu Ile Asp Met Glu Gln Ile Pro Gln Val Leu
     840                 845                 850

 aat cag gtt tct gga cag att ttg ccg gct ttt atc ctt tta ttt aac     2764
 Asn Gln Val Ser Gly Gln Ile Leu Pro Ala Phe Ile Leu Leu Phe Asn
 855                 860                 865                 870

 gga ttg aaa aga gca tat gcc tgc cat gca gaa cat gag aat gac agt     2812
 Gly Leu Lys Arg Ala Tyr Ala Cys His Ala Glu His Glu Asn Asp Ser
                 875                 880                 885

 gat gat gat gat gaa gct gaa gat gat gat gaa acc gag gaa ctg ggg     2860
 Asp Asp Asp Asp Glu Ala Glu Asp Asp Asp Glu Thr Glu Glu Leu Gly
             890                 895                 900

 agt gat gaa gat gat att gat gaa gat ggg caa gaa tat ttg gag att     2908
 Ser Asp Glu Asp Asp Ile Asp Glu Asp Gly Gln Glu Tyr Leu Glu Ile
         905                 910                 915

 ctg gct aag cag gct ggt gaa gat gga gat gat gaa gat tgg gaa gaa     2956
 Leu Ala Lys Gln Ala Gly Glu Asp Gly Asp Asp Glu Asp Trp Glu Glu
     920                 925                 930

 gat gat gct gaa gag act gct ctg gaa ggc tat tcc aca atc att gat     3004
 Asp Asp Ala Glu Glu Thr Ala Leu Glu Gly Tyr Ser Thr Ile Ile Asp
 935                 940                 945                 950

 gat gaa gat aac cct gtt gat gag tat cag ata ttt aaa gct atc ttt     3052
 Asp Glu Asp Asn Pro Val Asp Glu Tyr Gln Ile Phe Lys Ala Ile Phe
                 955                 960                 965

 caa act att caa aat cgt aat cct gtg tgg tat cag gca ctg act cac     3100
 Gln Thr Ile Gln Asn Arg Asn Pro Val Trp Tyr Gln Ala Leu Thr His
             970                 975                 980

 ggt ctt aat gaa gaa caa aga aaa cag tta cag gac ata gca act ctg     3148
 Gly Leu Asn Glu Glu Gln Arg Lys Gln Leu Gln Asp Ile Ala Thr Leu
         985                 990                 995

 gct gat caa aga aga gca gcc cat gaa tcc aaa atg att gag aag cat     3196
 Ala Asp Gln Arg Arg Ala Ala His Glu Ser Lys Met Ile Glu Lys His
    1000                1005                1010

 gga gga tac aaa ttc agt gct cca gtt gtg cca agt tct ttc aat ttt     3244
 Gly Gly Tyr Lys Phe Ser Ala Pro Val Val Pro Ser Ser Phe Asn Phe
1015                1020                1025                1030

 gga ggc cca gca cca ggg atg aat tga gttat ctctttcttt cctgctgtgt     3296
 Gly Gly Pro Ala Pro Gly Met Asn 
                1035

 gcttgtagtg aagagcttgt gttcctccta gtagtggttc cagaactggt tcatgttatc   3356

 tattctaaac taataatcaa tagatggaca aaagaaacaa caaccccagg agatgggacc   3416

 tgatcatgca acctggcact ggaaaagaaa tcagcgggat tttgggggtg gggggggatg   3476

 ggaggtacct tagagggagt attttcttta ttttttgaag aaagtaagat cctgactctg   3536

 aagcttcaaa gtgacactgt ggaaatctga aacgagggga tgtcatgaag gcagcttttc   3596

 tttttctgag gaaaaaatag gcatgggcta caggactatt taaaatgtct catttacagt   3656

 ataaaactca aaggtagatg taatttttac acctatgagt atttgtccaa tttctgtctc   3716

 ttcctcacca ttgggtatct attctttata tgtaaataag ataaggtcat ctgatagcct   3776

 tattcagtct tcatcatttt catcattgtt cctatgtaga ttattggaca tttattgtag   3836

 cactacataa ctgattataa aaatctgtaa atgaattagc actttcatat tgaaacaagc   3896

 ctgctagcct atgtataaaa tagcaaaatg tttgctgttt ataaaaagat gtaatggggt   3956

 ggggggcagg ggtaatttca agttattaat ttaaaaatga actagcaatt ttgtacctgg   4016

 tgactttgtg gtgcactcac ctctgatagt gacttgaatt cggtatgtaa aaaggggtta   4076

 gtggtatttc attgctgcta aaaatgacaa ctccctctgt gtcctgtttt tcttaaagct   4136

 gtcagtgtac aagtgggtat ttgaatacca gaccttactg taaaaaataa aaaaggtggt   4196

 atctagagca tgtaaattgg atataaagtt ctgctcttaa agagttgatc taagagtatg   4256

 gctaaacatc tatatatgca atctattaaa agaacttaat tcggctatta tgtcttgatt   4316

 tgattgcagt tttttcctaa ttataacaaa tttttcctca ttggcctgtt tttaatcctg   4376

 tgcctagaag gagtacaaaa tgcacacttt acaaaattga tatttaacac ttacccactc   4436

 ccctttcccc atctcttcta ccgctcttgt tgatcgtggt atctgatctt gactagatag   4496

 gctgaaggca catggttccc tccaaaaacc actattgata ccactacaaa aacaagccag   4556

 caaaaagata ctgtagagag gttggcttgc ttccctctct tcctaactgc atgttgaaaa   4616

 ataagccgtt attgatctta aacatcggtc agatgagtca tacattgggt tattttttat   4676

 atacatgtat acacaaaata tttcaaattg aaagcaacat cttaatggat tcaaaactat   4736

 tacaagctgt tgtctaaaac aggtgagaaa aaaatttata actgtaaaaa caaatgcaca   4796

 tattgatatt taaaatgcgt aattaagaaa acccattgtt gttgtgtttt tcttgtatac   4856

 caataattaa gccactactg ttggcactgt ttggttttct gttttaacac tgaaggagtg   4916

 aaagtatttc ctatatttat gaatttacta ctaaaatctt ggcaaaaaaa gaaaaaaatt   4976

 gtctaacatg tgtgggtgaa aactgttaat caagtgtttc tactcccccc cgaaaatccc   5036

 ctgaaagttg gacaccaact gtatacccta ggttgcttaa agggatttca ctattatata   5096

 aagtcaataa aaatgaagta gttgtatata tgcaacattg tgtacagagg ggaaataatg   5156

 aatagtatta aagaaacatt ctcgtcttcc tttaccttta atcccctaat acctagtcta   5216

 ctttttaaat tttcagactt cactgctttt tgaattcata attctaattt tcacattatt   5276

 gttaatggaa aatcatatct aataaaggtt ttagttattc ccatgcacag tatgaaaatt   5336

 ctcatttgct gaggttttgt ttcaagaaaa tgtattggca tgtctttgag aacatgtttt   5396

 attgtctcct gtgtcatata atccaaacta atctccgttt acagacttta acttgaaatt   5456

 agaccttata attaaactat ttaaatagtg ttcaaatgat agtttctaat gcatcaaata   5516

 tatacctcag ttttcatgat ttcctttaac attataattt ggtatagatc aagaatctta   5576

 acatgtatca gtttctagat gaggctgcag gatttttgga aaactttttg aatgtattta   5636

 caatattctc ttgtaattag ctacataggg acttgtcttt ttttcttttt acatacagct   5696

 tttcctacag ttttattacc ctgtaatttt tttttagttg tagaagttaa ttctgatttt   5756

 gtgtggattt cagtatttgt ctttgttaat ggcacatatt agcataaatc acttttgtaa   5816

 atgtaagctt tctttttttt tcttgaaaaa gcctttctat ttatcagtat taaataaagg   5876

 aagttaatct gtttctctgc aggtaataaa atagtgacac actgtattaa gatagtgact   5936

 gctatactca actctggaag agactagagt atagagcatg agtggcaaaa ccacagccct   5996

 tgggccatat gctgctattc agtcccagat gtagcccctg aagcaagcat aaagaaaaat   6056

 gaattaaaaa ttaaattaat atggaaagtt aaaaaatgga ttacattagt atgactaaac   6116

 catgtctttg gcaaagatct aacacaatgt cttaagtata ataggtagtc tctgtttgta   6176

 aaataaatga cttaaattta aaacaaaaaa aaaa                               6210




      <210> 324
      <211> 2460
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (105)..(2258)

      <400> 324
 gcgcccgctg taccggtccg gaattcccgg gtcgacgatt tcgtccgcgc tgagctgaag     60

 gctgtgcgga gcggcgcggc acagagcctg ttgttgagct cagt atg tcg tgg gaa     116
                                                  Met Ser Trp Glu
                                                    1

 tcc ggg gcc ggg cca ggt cta ggt tcc cag ggg atg gat ctc gtg tgg      164
 Ser Gly Ala Gly Pro Gly Leu Gly Ser Gln Gly Met Asp Leu Val Trp
   5                  10                  15                  20

 agt gcg tgg tac gga aag tgc gtt aaa ggg aaa ggg tcg ttg cca ctc      212
 Ser Ala Trp Tyr Gly Lys Cys Val Lys Gly Lys Gly Ser Leu Pro Leu
                  25                  30                  35

 tcg gcc cac ggc atc gtg gtc gcc tgg ctc agc agg gcc gag tgg gac      260
 Ser Ala His Gly Ile Val Val Ala Trp Leu Ser Arg Ala Glu Trp Asp
              40                  45                  50

 cag gtg acg gtt tat ctg ttc tgt gac gac cat aag ttg cag cgg tac      308
 Gln Val Thr Val Tyr Leu Phe Cys Asp Asp His Lys Leu Gln Arg Tyr
          55                  60                  65

 gcg ctt aac cgc atc acg gtg tgg agg agc agg tca ggc aac gaa ctc      356
 Ala Leu Asn Arg Ile Thr Val Trp Arg Ser Arg Ser Gly Asn Glu Leu
      70                  75                  80

 cct ctg gca gtg gct tct act gct gac ctg ata cgc tgt aag ctc ttg      404
 Pro Leu Ala Val Ala Ser Thr Ala Asp Leu Ile Arg Cys Lys Leu Leu
  85                  90                  95                 100

 gat gta act ggt ggc ttg ggc act gat gaa ctt aga ctg ctc tat ggc      452
 Asp Val Thr Gly Gly Leu Gly Thr Asp Glu Leu Arg Leu Leu Tyr Gly
                 105                 110                 115

 atg gca ttg gtc agg ttt gtg aat ctt atc tca gag agg aag aca aag      500
 Met Ala Leu Val Arg Phe Val Asn Leu Ile Ser Glu Arg Lys Thr Lys
             120                 125                 130

 ttt gcc aag gtc ccc ctc aag tgt ctg gct caa gag gta aat att ccg      548
 Phe Ala Lys Val Pro Leu Lys Cys Leu Ala Gln Glu Val Asn Ile Pro
         135                 140                 145

 gat tgg att gtt gac ctt cgc cat gag ttg acc cac aag aaa atg ccc      596
 Asp Trp Ile Val Asp Leu Arg His Glu Leu Thr His Lys Lys Met Pro
     150                 155                 160

 cat ata aat gac tgc cgc aga ggc tgc tac ttt gtc ctg gat tgg ctc      644
 His Ile Asn Asp Cys Arg Arg Gly Cys Tyr Phe Val Leu Asp Trp Leu
 165                 170                 175                 180

 cag aag acc tat tgg tgc cgc caa ctg gag aac agc ctg aga gag acc      692
 Gln Lys Thr Tyr Trp Cys Arg Gln Leu Glu Asn Ser Leu Arg Glu Thr
                 185                 190                 195

 tgg gag ttg gag gag ttc agg gaa ggg ata gag gaa gag gat caa gag      740
 Trp Glu Leu Glu Glu Phe Arg Glu Gly Ile Glu Glu Glu Asp Gln Glu
             200                 205                 210

 gaa gat aag aac att gtt gtt gat gac atc aca gaa cag aaa cca gag      788
 Glu Asp Lys Asn Ile Val Val Asp Asp Ile Thr Glu Gln Lys Pro Glu
         215                 220                 225

 cct cag gat gat ggg aaa agt acg gag tca gat gta aag gcc gat gga      836
 Pro Gln Asp Asp Gly Lys Ser Thr Glu Ser Asp Val Lys Ala Asp Gly
     230                 235                 240

 gac agc aaa ggc agc gaa gag gtg gat tct cat tgc aaa aag gcc ctg      884
 Asp Ser Lys Gly Ser Glu Glu Val Asp Ser His Cys Lys Lys Ala Leu
 245                 250                 255                 260

 agt cat aaa gag cta tat gaa aga gcc cga gaa ctg ctg gta tca tac      932
 Ser His Lys Glu Leu Tyr Glu Arg Ala Arg Glu Leu Leu Val Ser Tyr
                 265                 270                 275

 gaa gag gag cag ttt acg gtg ctg gag aaa ttt agg tat tta cct aag      980
 Glu Glu Glu Gln Phe Thr Val Leu Glu Lys Phe Arg Tyr Leu Pro Lys
             280                 285                 290

 gcc att aag gcg tgg aat aac ccg tcc cca cgt gta gaa tgt gtc ctg     1028
 Ala Ile Lys Ala Trp Asn Asn Pro Ser Pro Arg Val Glu Cys Val Leu
         295                 300                 305

 gca gag ctc aag ggc gtt aca tgc gag aac agg gag gct gtg ctg gat     1076
 Ala Glu Leu Lys Gly Val Thr Cys Glu Asn Arg Glu Ala Val Leu Asp
     310                 315                 320

 gct ttt ctg gat gat ggc ttc ctt gtc ccc aca ttt gaa cag ttg gca     1124
 Ala Phe Leu Asp Asp Gly Phe Leu Val Pro Thr Phe Glu Gln Leu Ala
 325                 330                 335                 340

 gct ttg cag ata gaa tat gaa gaa aac gtg gac ttg aat gac gtc ctg     1172
 Ala Leu Gln Ile Glu Tyr Glu Glu Asn Val Asp Leu Asn Asp Val Leu
                 345                 350                 355

 gtg cca aag ccg ttc tct cag ttc tgg cag ccc ctg ctc agg ggc ctg     1220
 Val Pro Lys Pro Phe Ser Gln Phe Trp Gln Pro Leu Leu Arg Gly Leu
             360                 365                 370

 cac tcc cag aac ttc acg cag gcc cta ttg gag agg atg ctc tct gaa     1268
 His Ser Gln Asn Phe Thr Gln Ala Leu Leu Glu Arg Met Leu Ser Glu
         375                 380                 385

 ctg cca gcc ttg ggg atc agc ggg atc cgg cct acc tac atc ctc aga     1316
 Leu Pro Ala Leu Gly Ile Ser Gly Ile Arg Pro Thr Tyr Ile Leu Arg
     390                 395                 400

 tgg acc gtt gaa ctg atc gtg gcc aac acc aag act gga cgg aat gct     1364
 Trp Thr Val Glu Leu Ile Val Ala Asn Thr Lys Thr Gly Arg Asn Ala
 405                 410                 415                 420

 cgc cga ttt tct gca ggc cag tgg gaa gca aga agg ggc tgg agg ctg     1412
 Arg Arg Phe Ser Ala Gly Gln Trp Glu Ala Arg Arg Gly Trp Arg Leu
                 425                 430                 435

 ttc aac tgc tcc gcc tcc ctt gac tgg ccc cgg atg gtt gag tcc tgc     1460
 Phe Asn Cys Ser Ala Ser Leu Asp Trp Pro Arg Met Val Glu Ser Cys
             440                 445                 450

 ttg ggc tca cct tgc tgg gcc agc ccc caa ctc ctt cgg atc atc ttc     1508
 Leu Gly Ser Pro Cys Trp Ala Ser Pro Gln Leu Leu Arg Ile Ile Phe
         455                 460                 465

 aaa gcc atg ggg cag ggc ctg cca gac gag gag cag gag aag ctg ctg     1556
 Lys Ala Met Gly Gln Gly Leu Pro Asp Glu Glu Gln Glu Lys Leu Leu
     470                 475                 480

 cgc atc tgt tcc att tat acc cag agt gga gaa aac agc ctg gtg cag     1604
 Arg Ile Cys Ser Ile Tyr Thr Gln Ser Gly Glu Asn Ser Leu Val Gln
 485                 490                 495                 500

 gag ggc tct gag gcc tcc ccc att ggg aag tct cca tat aca cta gac     1652
 Glu Gly Ser Glu Ala Ser Pro Ile Gly Lys Ser Pro Tyr Thr Leu Asp
                 505                 510                 515

 agc ctg tat tgg agc gtc aag cca gcc agc tcc agc ttc ggg tct gaa     1700
 Ser Leu Tyr Trp Ser Val Lys Pro Ala Ser Ser Ser Phe Gly Ser Glu
             520                 525                 530

 gca aag gcc cag caa cag gag gag cag ggc agt gtt aat gat gtc aag     1748
 Ala Lys Ala Gln Gln Gln Glu Glu Gln Gly Ser Val Asn Asp Val Lys
         535                 540                 545

 gaa gag gag aag gag gag aaa gag gtc ttg cca gac cag gaa gag gag     1796
 Glu Glu Glu Lys Glu Glu Lys Glu Val Leu Pro Asp Gln Glu Glu Glu
     550                 555                 560

 gat gaa gat gat gaa gat gat gaa gag gaa gag gag gat gaa gat gat     1844
 Asp Glu Asp Asp Glu Asp Asp Glu Glu Glu Glu Glu Asp Glu Asp Asp
 565                 570                 575                 580

 gaa gat gat gaa gag gaa gac aga atg gag gtg ggg cct ttc tct aca     1892
 Glu Asp Asp Glu Glu Glu Asp Arg Met Glu Val Gly Pro Phe Ser Thr
                 585                 590                 595

 ggg caa gag tcc ccc act gcc gag aat gct agg ctt ctg gcc cag aaa     1940
 Gly Gln Glu Ser Pro Thr Ala Glu Asn Ala Arg Leu Leu Ala Gln Lys
             600                 605                 610

 aga gga gct ttg cag ggc tct gca tgg cag gtt agc tca gaa gac gtg     1988
 Arg Gly Ala Leu Gln Gly Ser Ala Trp Gln Val Ser Ser Glu Asp Val
         615                 620                 625

 cga tgg gac aca ttt ccc cta ggc cga atg cca ggt cag acc gag gac     2036
 Arg Trp Asp Thr Phe Pro Leu Gly Arg Met Pro Gly Gln Thr Glu Asp
     630                 635                 640

 cca gca gag ctc atg ctg gag aat tat gac acc atg tat ctt ttg gac     2084
 Pro Ala Glu Leu Met Leu Glu Asn Tyr Asp Thr Met Tyr Leu Leu Asp
 645                 650                 655                 660

 cag cct gtg cta gag cag cgg ctg gaa ccc tca aca tgc aag act gac     2132
 Gln Pro Val Leu Glu Gln Arg Leu Glu Pro Ser Thr Cys Lys Thr Asp
                 665                 670                 675

 acc ttg ggc ctg agc tgt ggt gtc ggc agt ggc aac tgc agc aac agc     2180
 Thr Leu Gly Leu Ser Cys Gly Val Gly Ser Gly Asn Cys Ser Asn Ser
             680                 685                 690

 agc agc agc aac ttc gag ggc ctt ctc tgg agc cag ggg cag ctg cat     2228
 Ser Ser Ser Asn Phe Glu Gly Leu Leu Trp Ser Gln Gly Gln Leu His
         695                 700                 705

 ggg ctc aaa act ggc ctg cag ctc ttc tga t ggccatccct ggtgcaagtg     2279
 Gly Leu Lys Thr Gly Leu Gln Leu Phe 
     710                 715

 ttcatccagc cgtgccaggg caacagccca ccccctagta caactgatgc tccctgagac   2339

 aacctgggag acagcctgga tcagccacat caactcagtt gtccaccaca ggggaatttt   2399

 gaatgtcttt tgtttttgtt ttgttttgaa aaataataaa caggcaactg taaaaaaaaa   2459

 a                                                                   2460




      <210> 325
      <211> 4997
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (186)..(3008)

      <400> 325
 tggcaccgcg tttgtcaagt tttctactct tacaaaggaa ctgtccacac tgctgaaaaa     60

 tctgctccag ggtttgagcc acaatgtgat cttcaccttg gattctttgt taaaaggaga    120

 cctaaaggga gtcaaaggat acaaaaattg agaaagagaa aagagagcac gcaaaacaac    180

 atggg    atg atc cgc aca gag ata aca gga gct gag att gcg gaa gaa     227
          Met Ile Arg Thr Glu Ile Thr Gly Ala Glu Ile Ala Glu Glu
            1               5                  10

 atg gag aag gaa agg cgc ctc ttt cag ctc caa atg tgt gaa tat ctc      275
 Met Glu Lys Glu Arg Arg Leu Phe Gln Leu Gln Met Cys Glu Tyr Leu
  15                  20                  25                  30

 att aaa gtt aat gaa atc aag acc aaa aag ggt gtg gat ctg ctg cag      323
 Ile Lys Val Asn Glu Ile Lys Thr Lys Lys Gly Val Asp Leu Leu Gln
                  35                  40                  45

 aat ctt ata aag tat tac cat gca cag tgc aat ttc ttt caa gat ggc      371
 Asn Leu Ile Lys Tyr Tyr His Ala Gln Cys Asn Phe Phe Gln Asp Gly
              50                  55                  60

 ttg aaa aca gct gat aag ttg aaa cag tac att gaa aaa ctg gct gct      419
 Leu Lys Thr Ala Asp Lys Leu Lys Gln Tyr Ile Glu Lys Leu Ala Ala
          65                  70                  75

 gat tta tat aat ata aaa cag acc cag gat gaa gaa aag aaa cag cta      467
 Asp Leu Tyr Asn Ile Lys Gln Thr Gln Asp Glu Glu Lys Lys Gln Leu
      80                  85                  90

 act gca ctc cga gac tta ata aaa tcc tct ctt caa ctg gat cag aaa      515
 Thr Ala Leu Arg Asp Leu Ile Lys Ser Ser Leu Gln Leu Asp Gln Lys
  95                 100                 105                 110

 gaa tct agg aga gat tct cag agc cgg caa gga gga tac agc atg cat      563
 Glu Ser Arg Arg Asp Ser Gln Ser Arg Gln Gly Gly Tyr Ser Met His
                 115                 120                 125

 cag ctc cag ggc aat aag gaa tat ggc agt gaa aag aag ggg tac ctg      611
 Gln Leu Gln Gly Asn Lys Glu Tyr Gly Ser Glu Lys Lys Gly Tyr Leu
             130                 135                 140

 cta aag aaa agt gac ggg atc cgg aaa gta tgg cag agg agg aag tgt      659
 Leu Lys Lys Ser Asp Gly Ile Arg Lys Val Trp Gln Arg Arg Lys Cys
         145                 150                 155

 tca gtc aag aat ggg att cta acc atc tca cat gcc aca tct aac agg      707
 Ser Val Lys Asn Gly Ile Leu Thr Ile Ser His Ala Thr Ser Asn Arg
     160                 165                 170

 caa cca gcc aag ttg aac ctt ctc acc tgc caa gta aaa cct aat gcc      755
 Gln Pro Ala Lys Leu Asn Leu Leu Thr Cys Gln Val Lys Pro Asn Ala
 175                 180                 185                 190

 gaa gac aaa aaa tct ttt gac ctg ata tca cat aat aga aca tat cac      803
 Glu Asp Lys Lys Ser Phe Asp Leu Ile Ser His Asn Arg Thr Tyr His
                 195                 200                 205

 ttt cag gca gaa gat gag cag gat tat gta gca tgg ata tca gta ttg      851
 Phe Gln Ala Glu Asp Glu Gln Asp Tyr Val Ala Trp Ile Ser Val Leu
             210                 215                 220

 aca aat agc aaa gaa gag gcc cta acc atg gcc ttc cgt gga gag cag      899
 Thr Asn Ser Lys Glu Glu Ala Leu Thr Met Ala Phe Arg Gly Glu Gln
         225                 230                 235

 agt gcg gga gag aac agc ctg gaa gac ctg aca aaa gcc att att gag      947
 Ser Ala Gly Glu Asn Ser Leu Glu Asp Leu Thr Lys Ala Ile Ile Glu
     240                 245                 250

 gat gtc cag cgg ctc cca ggg aat gac att tgc tgc gat tgt ggc tca      995
 Asp Val Gln Arg Leu Pro Gly Asn Asp Ile Cys Cys Asp Cys Gly Ser
 255                 260                 265                 270

 tca gaa ccc acc tgg ctt tca acc aac ttg ggt att ttg acc tgt ata     1043
 Ser Glu Pro Thr Trp Leu Ser Thr Asn Leu Gly Ile Leu Thr Cys Ile
                 275                 280                 285

 gaa tgt tct ggc atc cat agg gaa atg ggg gtt cat att tct cgc att     1091
 Glu Cys Ser Gly Ile His Arg Glu Met Gly Val His Ile Ser Arg Ile
             290                 295                 300

 cag tct ttg gaa cta gac aaa tta gga act tct gaa ctc ttg ctg gcc     1139
 Gln Ser Leu Glu Leu Asp Lys Leu Gly Thr Ser Glu Leu Leu Leu Ala
         305                 310                 315

 aag aat gta gga aac aat agt ttt aat gat att atg gaa gca aat tta     1187
 Lys Asn Val Gly Asn Asn Ser Phe Asn Asp Ile Met Glu Ala Asn Leu
     320                 325                 330

 ccc agc ccc tca cca aaa ccc acc cct tca agt gat atg act gta cga     1235
 Pro Ser Pro Ser Pro Lys Pro Thr Pro Ser Ser Asp Met Thr Val Arg
 335                 340                 345                 350

 aaa gaa tat atc act gca aag tat gta gat cat agg ttt tca agg aag     1283
 Lys Glu Tyr Ile Thr Ala Lys Tyr Val Asp His Arg Phe Ser Arg Lys
                 355                 360                 365

 acc tgt tca act tca tca gct aaa cta aat gaa ttg ctt gag gcc atc     1331
 Thr Cys Ser Thr Ser Ser Ala Lys Leu Asn Glu Leu Leu Glu Ala Ile
             370                 375                 380

 aaa tcc agg gat tta ctt gca cta att caa gtc tat gca gaa ggg gta     1379
 Lys Ser Arg Asp Leu Leu Ala Leu Ile Gln Val Tyr Ala Glu Gly Val
         385                 390                 395

 gag cta atg gaa cca ctg ctg gaa cct ggg cag gag ctt ggg gag aca     1427
 Glu Leu Met Glu Pro Leu Leu Glu Pro Gly Gln Glu Leu Gly Glu Thr
     400                 405                 410

 gcc ctt cac ctt gcc gtc cga act gca gat cag aca tct ctc cat ttg     1475
 Ala Leu His Leu Ala Val Arg Thr Ala Asp Gln Thr Ser Leu His Leu
 415                 420                 425                 430

 gtt gac ttc ctt gta caa aac tgt ggg aac ctg gat aag cag acg gcc     1523
 Val Asp Phe Leu Val Gln Asn Cys Gly Asn Leu Asp Lys Gln Thr Ala
                 435                 440                 445

 ctg gga aac aca gtt cta cac tac tgt agt atg tac agt aaa cct gag     1571
 Leu Gly Asn Thr Val Leu His Tyr Cys Ser Met Tyr Ser Lys Pro Glu
             450                 455                 460

 tgt ttg aag ctt ttg ctc agg agc aag ccc act gtg gat ata gtt aac     1619
 Cys Leu Lys Leu Leu Leu Arg Ser Lys Pro Thr Val Asp Ile Val Asn
         465                 470                 475

 cag gct gga gaa act gcc cta gac ata gca aag aga cta aaa gct acc     1667
 Gln Ala Gly Glu Thr Ala Leu Asp Ile Ala Lys Arg Leu Lys Ala Thr
     480                 485                 490

 cag tgt gaa gat ctg ctt tcc cag gct aaa tct gga aag ttc aat cca     1715
 Gln Cys Glu Asp Leu Leu Ser Gln Ala Lys Ser Gly Lys Phe Asn Pro
 495                 500                 505                 510

 cac gtc cac gta gaa tat gag tgg aat ctt cga cag gag gag ata gat     1763
 His Val His Val Glu Tyr Glu Trp Asn Leu Arg Gln Glu Glu Ile Asp
                 515                 520                 525

 gag agc gat gat gat ctg gat gac aaa cca agc cct atc aag aaa gag     1811
 Glu Ser Asp Asp Asp Leu Asp Asp Lys Pro Ser Pro Ile Lys Lys Glu
             530                 535                 540

 cgc tca ccc aga cct cag agc ttc tgc cac tcc tcc agc atc tcc ccc     1859
 Arg Ser Pro Arg Pro Gln Ser Phe Cys His Ser Ser Ser Ile Ser Pro
         545                 550                 555

 cag gac aag ctg gca ctg cca gga ttc agc act cca agg gac aaa cag     1907
 Gln Asp Lys Leu Ala Leu Pro Gly Phe Ser Thr Pro Arg Asp Lys Gln
     560                 565                 570

 cgg ctc tcc tat gga gcc ttc acc aac cag atc ttc gtt tcc aca agc     1955
 Arg Leu Ser Tyr Gly Ala Phe Thr Asn Gln Ile Phe Val Ser Thr Ser
 575                 580                 585                 590

 aca gac tcg ccc aca tca cca acc acg gag gct ccc cct ctg cct cct     2003
 Thr Asp Ser Pro Thr Ser Pro Thr Thr Glu Ala Pro Pro Leu Pro Pro
                 595                 600                 605

 agg aac gcc ggg aaa ggt cca act ggc cca cct tca aca ctc cct cta     2051
 Arg Asn Ala Gly Lys Gly Pro Thr Gly Pro Pro Ser Thr Leu Pro Leu
             610                 615                 620

 agc acc cag acc tct agt ggc agc tcc acc cta tcc aag aag agg cct     2099
 Ser Thr Gln Thr Ser Ser Gly Ser Ser Thr Leu Ser Lys Lys Arg Pro
         625                 630                 635

 cct ccc cca cca ccc gga cac aag aga acc cta tcc gac cct ccc agc     2147
 Pro Pro Pro Pro Pro Gly His Lys Arg Thr Leu Ser Asp Pro Pro Ser
     640                 645                 650

 cca cta cct cat ggg ccc cca aac aaa ggc gca gtt cct tgg ggt aac     2195
 Pro Leu Pro His Gly Pro Pro Asn Lys Gly Ala Val Pro Trp Gly Asn
 655                 660                 665                 670

 gat ggg ggt cca tcc tct tca agt aag act aca aac aag ttt gag gga     2243
 Asp Gly Gly Pro Ser Ser Ser Ser Lys Thr Thr Asn Lys Phe Glu Gly
                 675                 680                 685

 cta tcc cag cag tcg agc acc agt tct gca aag act gcc ctt ggc cca     2291
 Leu Ser Gln Gln Ser Ser Thr Ser Ser Ala Lys Thr Ala Leu Gly Pro
             690                 695                 700

 aga gtt ctt cct aaa cta cct cag aaa gtg gca cta agg aaa aca gat     2339
 Arg Val Leu Pro Lys Leu Pro Gln Lys Val Ala Leu Arg Lys Thr Asp
         705                 710                 715

 cat ctc tcc cta gac aaa gcc acc atc ccg ccc gaa atc ttt cag aaa     2387
 His Leu Ser Leu Asp Lys Ala Thr Ile Pro Pro Glu Ile Phe Gln Lys
     720                 725                 730

 tca tca cag ttg gca gag ttg cca caa aag cca cca cct gga gac ctg     2435
 Ser Ser Gln Leu Ala Glu Leu Pro Gln Lys Pro Pro Pro Gly Asp Leu
 735                 740                 745                 750

 ccc cca aag ccc aca gaa ctg gcc ccc aag ccc caa att gga gat ttg     2483
 Pro Pro Lys Pro Thr Glu Leu Ala Pro Lys Pro Gln Ile Gly Asp Leu
                 755                 760                 765

 ccg cct aag cca gga gaa ctg ccc ccc aaa cca cag ctg ggg gac ctg     2531
 Pro Pro Lys Pro Gly Glu Leu Pro Pro Lys Pro Gln Leu Gly Asp Leu
             770                 775                 780

 cca ccc aaa ccc caa ctc tca gac tta cct ccc aaa cca cag atg aag     2579
 Pro Pro Lys Pro Gln Leu Ser Asp Leu Pro Pro Lys Pro Gln Met Lys
         785                 790                 795

 gac ctg ccc ccc aaa cca cag ctg gga gac ctg cta gca aaa tcc cag     2627
 Asp Leu Pro Pro Lys Pro Gln Leu Gly Asp Leu Leu Ala Lys Ser Gln
     800                 805                 810

 act gga gat gtc tca ccc aag gct cag caa ccc tct gag gtc aca ctg     2675
 Thr Gly Asp Val Ser Pro Lys Ala Gln Gln Pro Ser Glu Val Thr Leu
 815                 820                 825                 830

 aag tca cac cca ttg gat cta tcc cca aat gtg cag tcc aga gac gcc     2723
 Lys Ser His Pro Leu Asp Leu Ser Pro Asn Val Gln Ser Arg Asp Ala
                 835                 840                 845

 atc caa aag caa gca tct gaa gac tcc aac gac ctc acg cct act ctg     2771
 Ile Gln Lys Gln Ala Ser Glu Asp Ser Asn Asp Leu Thr Pro Thr Leu
             850                 855                 860

 cca gag acg ccc gta cca ctg ccc aga aaa atc aat acg ggg aaa aat     2819
 Pro Glu Thr Pro Val Pro Leu Pro Arg Lys Ile Asn Thr Gly Lys Asn
         865                 870                 875

 aaa gtg agg cga gtg aag acc att tat gac tgc cag gca gac aac gat     2867
 Lys Val Arg Arg Val Lys Thr Ile Tyr Asp Cys Gln Ala Asp Asn Asp
     880                 885                 890

 gac gag ctc aca ttc atc gag gga gaa gtg att atc gtc aca ggg gaa     2915
 Asp Glu Leu Thr Phe Ile Glu Gly Glu Val Ile Ile Val Thr Gly Glu
 895                 900                 905                 910

 gag gac cag gag tgg tgg att ggc cac atc gaa gga cag cct gaa agg     2963
 Glu Asp Gln Glu Trp Trp Ile Gly His Ile Glu Gly Gln Pro Glu Arg
                 915                 920                 925

 aag ggg gtc ttt cca gtg tcc ttt gtt cat atc ctg tct gac tag caa     3011
 Lys Gly Val Phe Pro Val Ser Phe Val His Ile Leu Ser Asp 
             930                 935                 940

 aacgcagaac cttaagattg tccacatcct tcatgcaaga ctgctgcctt catgtaaccc   3071

 tgggcacagt gtgtatatag ctgctgttac agagtaagaa actcatggaa gggccacctc   3131

 aggaggggga tataatgtgt gttgtaaata tcctgtggtt ttctgccttc accagtatga   3191

 gggtagcctc ggacccggcg cgccttactg gtttgccaaa gccatccttg gcatctagca   3251

 cttacatctc tctatgctgt tctacaagca aacaaacaaa aataggagta taggaactgc   3311

 tggctttgca aatagaagtg gtctccagca accgttgaaa ggcatagaat tgactctgtt   3371

 cctaacaatg cagtattctc aattgtgtta ctgaaaatgc aacattagca aagaggtggg   3431

 ttctgttttc caggtgaaac ttttagctcc atgacagacc agcctgtagt tatctgtgta   3491

 cacagtttac agctacaaaa acctactttg gtatttatta cagaaaagtg ctcagttaaa   3551

 tgtaagtgtt attccttcag caaaatattc actgacccaa aactctttat ggcattttac   3611

 aatgcacaca gcctcatgca agtttagaca agtggattta tactgtctta tgagtgcccg   3671

 cccctgatat attacctcat tatgcaaaaa taacatatct ttcatgacta ttttgacaaa   3731

 agtttaaaac acatatgaag ttcaaatttc aggaaccaag gactgccaga aaatattagc   3791

 ctctacatta cgcatgcatt tagaagctta cctgaaatct gccttttata aaggaatagt   3851

 atggataagt ggaattgtac attttttaaa cttgattgcc attaaagcag aaattataag   3911

 gttgcaacaa tatttgtttc taatcactgg ctttctcaag agtatggatt gacatattgt   3971

 gttatgaatg cacatctctc agatgtgttg aagcatccat tgcatccatt ttttattatt   4031

 ttcttagttt tgttcttgga caaatttaaa cttttaaaag attattcaag atgaatttaa   4091

 aagtcaaccc ttcacacagt ttccctactg tatgtagaat ccaggtgctg aaaccaagtg   4151

 tttcttttcc catgctcttt gttaaacccc aattatagat aatttttcca gtcttaagct   4211

 ctgtccacct tcaagtcaat tcataaccaa gtttttgaac gctgctatga attgcactgt   4271

 gaaaagcact cttccctctc agttttcttt tcatcccagc catgtttatc agatccttaa   4331

 gaacattgta tttcagtctt ttacatcagt ctgaattttg gaaaagaatg caatagttgt   4391

 actccacagt cagtggaact gttccctgag tccgaggctc atgtgtcatt ctggcactac   4451

 atttgcttaa attgctattt tggcaacagc acagaaaact aatattttta agcagagaat   4511

 cttggcaatg agtgagagat gttaatttca cagaagcaca actcccaacc caacccttag   4571

 gaaaagccct cttccatcgt tacagtgctc agtgaatatt aatttagttc tgcttaagtg   4631

 gttgctatac aaactttgaa tagccaccta ataaataaac cttgcatgac aaacctgcaa   4691

 aatattttat cagctgttat tggaaagtga ttttaagcaa ttgcttcctc agtgtcaggg   4751

 cacatgtgaa tttccacacc aaacagagca tgaggaacca gttgacatgc tgggttgtga   4811

 ctggcagctt tagcagcctc ggtactgaag ccacaccagt gtccggatgg aagtctgcat   4871

 ctgaggttgc tcagtgtccc ggtcattcat ttacacattt taacttgcat taaagagctg   4931

 ttcttttctg tggcctagac tcttttcact gatctcaaaa taaactggtt tttttcaaaa   4991

 aaaaaa                                                              4997




      <210> 326
      <211> 354
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(260)

      <220>
      <221> misc_feature
      <222> (1)...(354)
      <223> n = a,t,c or g

      <400> 326
 ggcacagagc ccccggaact ggcatctgca gggcgtgagc ttttgccgcc gcg   atg      56
                                                              Met
                                                                1

 ccg cac ttc ctg gac tgg ttc gtg ccg gtc tac ttg gtc atc tcg gtc      104
 Pro His Phe Leu Asp Trp Phe Val Pro Val Tyr Leu Val Ile Ser Val
               5                  10                  15

 ctc att ctg ggg ggc ttc ggc gcc tgc atc tac tac ttc gag ccg ggc      152
 Leu Ile Leu Gly Gly Phe Gly Ala Cys Ile Tyr Tyr Phe Glu Pro Gly
          20                  25                  30

 ctg cag gag gcg cac aag tgg cgc atg cag cgc ccc ctg gtg gac cgc      200
 Leu Gln Glu Ala His Lys Trp Arg Met Gln Arg Pro Leu Val Asp Arg
      35                  40                  45

 gac ctc cgc aag acg cta atg gtg cgc gac aac ctg gcc ttc ggc ggc      248
 Asp Leu Arg Lys Thr Leu Met Val Arg Asp Asn Leu Ala Phe Gly Gly
  50                  55                  60                  65

 ccg gag gtc tga gcc gacttgcaaa ggggataggc gggcggnacc gggcgccctt      303
 Pro Glu Val 


 ccccagcccg ccccgcccgc ccagcccgga gacccccaag gcagagggag g             354




      <210> 327
      <211> 2427
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (107)..(2059)

      <400> 327
 agactcagac atcattatta ttttaaactc cacaagtgtt ttaatgttta gccaagttta     60

 agaaccaata cttttagaaa gcattaggaa agaatgccag tatagc   atg gtg gaa     115
                                                      Met Val Glu
                                                        1

 agc gta agg ctt gag aac cag ccc tgt gac cta aga gtg ggc agc tgg      163
 Ser Val Arg Leu Glu Asn Gln Pro Cys Asp Leu Arg Val Gly Ser Trp
       5                  10                  15

 atc cac gtc tac cct aat gga tcc ctg ttt att gga tca gta aca gaa      211
 Ile His Val Tyr Pro Asn Gly Ser Leu Phe Ile Gly Ser Val Thr Glu
  20                  25                  30                  35

 aaa gac agt ggt gtc tac ttg tgt gtg gca aga aac aaa atg ggg gat      259
 Lys Asp Ser Gly Val Tyr Leu Cys Val Ala Arg Asn Lys Met Gly Asp
                  40                  45                  50

 gat ctg ata ctg atg cat gtt agc cta aga ctg aaa cct gcc aaa att      307
 Asp Leu Ile Leu Met His Val Ser Leu Arg Leu Lys Pro Ala Lys Ile
              55                  60                  65

 gac cac aag cag tat ttt aga aag caa gtg ctc cat ggg aaa gat ttc      355
 Asp His Lys Gln Tyr Phe Arg Lys Gln Val Leu His Gly Lys Asp Phe
          70                  75                  80

 caa gta gat tgc aaa gct tcc ggc tcc cca gtg cca gag ata tct tgg      403
 Gln Val Asp Cys Lys Ala Ser Gly Ser Pro Val Pro Glu Ile Ser Trp
      85                  90                  95

 agt ttg ctt gat gga acc atg atc aac aat gca atg caa gcc gat gac      451
 Ser Leu Leu Asp Gly Thr Met Ile Asn Asn Ala Met Gln Ala Asp Asp
 100                 105                 110                 115

 agt ggc cac agg act agg aga tat acc ctt ttc aac aat gga act tta      499
 Ser Gly His Arg Thr Arg Arg Tyr Thr Leu Phe Asn Asn Gly Thr Leu
                 120                 125                 130

 tac ttc aac aaa gtt ggg gta gcg gag gaa gga gat tat act tgc tat      547
 Tyr Phe Asn Lys Val Gly Val Ala Glu Glu Gly Asp Tyr Thr Cys Tyr
             135                 140                 145

 gcc cag aac acc cta ggg aaa gat gaa atg aag gtc cac tta aca gtt      595
 Ala Gln Asn Thr Leu Gly Lys Asp Glu Met Lys Val His Leu Thr Val
         150                 155                 160

 ata aca gct gct ccc cgg ata agg cag agt aac aaa acc aac aag aga      643
 Ile Thr Ala Ala Pro Arg Ile Arg Gln Ser Asn Lys Thr Asn Lys Arg
     165                 170                 175

 atc aaa gct gga gac aca gct gtc ctt gac tgt gag gtc act ggg gat      691
 Ile Lys Ala Gly Asp Thr Ala Val Leu Asp Cys Glu Val Thr Gly Asp
 180                 185                 190                 195

 ccc aaa cca aaa ata ttt tgg ttg ctg cct tcc aat gac atg att tcc      739
 Pro Lys Pro Lys Ile Phe Trp Leu Leu Pro Ser Asn Asp Met Ile Ser
                 200                 205                 210

 ttc tcc att gat agg tac aca ttt cat gcc aat ggg tct ttg acc atc      787
 Phe Ser Ile Asp Arg Tyr Thr Phe His Ala Asn Gly Ser Leu Thr Ile
             215                 220                 225

 aac aaa gtg aaa ctg ctc gat tct gga gag tac gta tgt gta gcc cga      835
 Asn Lys Val Lys Leu Leu Asp Ser Gly Glu Tyr Val Cys Val Ala Arg
         230                 235                 240

 aat ccc agt ggg gat gac acc aaa atg tac aaa ctg gat gtg gtc tct      883
 Asn Pro Ser Gly Asp Asp Thr Lys Met Tyr Lys Leu Asp Val Val Ser
     245                 250                 255

 aaa cct cca tta atc aat ggt ctg tat aca aat aga act gtt att aaa      931
 Lys Pro Pro Leu Ile Asn Gly Leu Tyr Thr Asn Arg Thr Val Ile Lys
 260                 265                 270                 275

 gcc aca gct gtg aga cat tcc aaa aaa cac ttt gac tgc aga gct gaa      979
 Ala Thr Ala Val Arg His Ser Lys Lys His Phe Asp Cys Arg Ala Glu
                 280                 285                 290

 ggg aca cca tct cct gaa gtc atg tgg atc atg cca gac aat att ttc     1027
 Gly Thr Pro Ser Pro Glu Val Met Trp Ile Met Pro Asp Asn Ile Phe
             295                 300                 305

 ctc aca gcc cca tac tat gga agc aga atc aca gtc cat aaa aat gga     1075
 Leu Thr Ala Pro Tyr Tyr Gly Ser Arg Ile Thr Val His Lys Asn Gly
         310                 315                 320

 acc ttg gaa att agg aat gtg agg ctt tca gat tca gcc gac ttt atc     1123
 Thr Leu Glu Ile Arg Asn Val Arg Leu Ser Asp Ser Ala Asp Phe Ile
     325                 330                 335

 tgt gtg gcc cga aat gaa ggt gga gag agc gtg ttg gta gta cag tta     1171
 Cys Val Ala Arg Asn Glu Gly Gly Glu Ser Val Leu Val Val Gln Leu
 340                 345                 350                 355

 gaa gta ctg gaa atg ctg aga aga ccg aca ttt aga aat cca ttt aat     1219
 Glu Val Leu Glu Met Leu Arg Arg Pro Thr Phe Arg Asn Pro Phe Asn
                 360                 365                 370

 gaa aaa ata gtt gcc cag ctg gga aag tcc aca gca ttg aat tgc tct     1267
 Glu Lys Ile Val Ala Gln Leu Gly Lys Ser Thr Ala Leu Asn Cys Ser
             375                 380                 385

 gtt gat ggt aac cca cca cct gaa ata atc tgg att tta cca aat ggc     1315
 Val Asp Gly Asn Pro Pro Pro Glu Ile Ile Trp Ile Leu Pro Asn Gly
         390                 395                 400

 aca cga ttt tcc aat gga cca caa agt tat cag tat ctg ata gca agc     1363
 Thr Arg Phe Ser Asn Gly Pro Gln Ser Tyr Gln Tyr Leu Ile Ala Ser
     405                 410                 415

 aat ggt tct ttt atc att tct aaa aca act cgg gag gat gca gga aaa     1411
 Asn Gly Ser Phe Ile Ile Ser Lys Thr Thr Arg Glu Asp Ala Gly Lys
 420                 425                 430                 435

 tat cgc tgt gca gct agg aat aaa gtt ggc tat att gag aaa tta gtc     1459
 Tyr Arg Cys Ala Ala Arg Asn Lys Val Gly Tyr Ile Glu Lys Leu Val
                 440                 445                 450

 ata tta gaa att ggc cag aag cca gtt att ctt acc tat gca cca ggg     1507
 Ile Leu Glu Ile Gly Gln Lys Pro Val Ile Leu Thr Tyr Ala Pro Gly
             455                 460                 465

 aca gta aaa ggc atc agt gga gaa tct cta tca ctg cat tgt gtg tct     1555
 Thr Val Lys Gly Ile Ser Gly Glu Ser Leu Ser Leu His Cys Val Ser
         470                 475                 480

 gat gga atc cct aag cca aat atc aaa tgg act atg cca agt ggt tat     1603
 Asp Gly Ile Pro Lys Pro Asn Ile Lys Trp Thr Met Pro Ser Gly Tyr
     485                 490                 495

 gta gta gac agg cct caa att aat ggg aaa tac ata ttg cat gac aat     1651
 Val Val Asp Arg Pro Gln Ile Asn Gly Lys Tyr Ile Leu His Asp Asn
 500                 505                 510                 515

 ggc acc tta gtc att aaa gaa gca aca gct tat gac aga gga aac tat     1699
 Gly Thr Leu Val Ile Lys Glu Ala Thr Ala Tyr Asp Arg Gly Asn Tyr
                 520                 525                 530

 atc tgt aag gct caa aat agt gtt ggt cat aca ctg att act gtt cca     1747
 Ile Cys Lys Ala Gln Asn Ser Val Gly His Thr Leu Ile Thr Val Pro
             535                 540                 545

 gta atg att gta gcc tac cct ccc cga att aca aat cgt cca ccc agg     1795
 Val Met Ile Val Ala Tyr Pro Pro Arg Ile Thr Asn Arg Pro Pro Arg
         550                 555                 560

 agt att gtc acc agg aca ggg gca gcc ttt cag ctc cac tgt gtg gcc     1843
 Ser Ile Val Thr Arg Thr Gly Ala Ala Phe Gln Leu His Cys Val Ala
     565                 570                 575

 ttg gga gtt ccc aag cca gaa atc acg tgg gag atg cct gac cac tcc     1891
 Leu Gly Val Pro Lys Pro Glu Ile Thr Trp Glu Met Pro Asp His Ser
 580                 585                 590                 595

 ctt ctc tca acg gca agt aaa gag agg aca cat gga agt gag cag ctt     1939
 Leu Leu Ser Thr Ala Ser Lys Glu Arg Thr His Gly Ser Glu Gln Leu
                 600                 605                 610

 cac tta caa ggt acc cta gtc att cag aat ccc caa acc tcc gat tct     1987
 His Leu Gln Gly Thr Leu Val Ile Gln Asn Pro Gln Thr Ser Asp Ser
             615                 620                 625

 ggg ata tac aaa tgc aca gca aag aac cca ctt ggt agt gat tat gca     2035
 Gly Ile Tyr Lys Cys Thr Ala Lys Asn Pro Leu Gly Ser Asp Tyr Ala
         630                 635                 640

 gca acg tat att caa gta atc tga catgaaataa taaagtcaac aacatctggg    2089
 Ala Thr Tyr Ile Gln Val Ile 
     645                 650

 cagaatttat tttttggaag aagtttaatc aaaggcagcc ataggcatgt aaatgaattt   2149

 gaatacattt acagtattaa atttacaatg aacatgcaaa ataaaaggac ttgtaaataa   2209

 atgcattatg aactgatgat actgatttat ttaatggatc tcaaaacaaa cttttaactt   2269

 aaggcacttt tattttgcca acaaataaca ataaacaaac attgaaacgg ttcactataa   2329

 aataacaaat ggctaatgta cctgaatttt tcagtaaaaa aatgaacttc caataccagt   2389

 tgcctagtgt ccacctccta tcaatgttac aggcatgg                           2427




      <210> 328
      <211> 1840
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (512)..(1459)

      <400> 328
 gcggagccgc cgccgcgcgg cggggcttct cactctgacg ggcccgcgcg cacgatggcc     60

 ggcgcctgct gccgctgggt ccgctacctg gcgggcttct gctgccctct cgggggcctg    120

 gctggcgggc aagccccgcg tgctgtgcca tgaggcagag gtcttcctgt ccaccgggag    180

 cgagctcgtc tacgtgtacg accaggaggg cgggctgctg accgcggcgt tccggttccc    240

 cgaccaggtg tggcacctgg agctgctggc gccgcgcagg ttgctgtacg cgctgtgcgc    300

 ccggaggggc ctctactgcc tgtcgctgga ccacccgggc aggagcaggt ctacgagcca    360

 ggatgacagg gacagcgagg acggtgacca gccttccccc gtgatccctg tggaccccga    420

 tgcctgcatc cttcccgatg ctgcgctgtg cgcgttcacc ttgctggaca gtgtgctggt    480

 caccctggtg cagggccctg cccgatggaa g   atg cag ctg ttt gag cag ccc     532
                                      Met Gln Leu Phe Glu Gln Pro
                                        1               5

 tgt cct ggg gag gac ccc cgg cca gga ggc cag atc ggt gag gtg gag      580
 Cys Pro Gly Glu Asp Pro Arg Pro Gly Gly Gln Ile Gly Glu Val Glu
          10                  15                  20

 ctg tcc tcc tac acg ccc cca gcc ggg gtc cca gga aag cct gca gcc      628
 Leu Ser Ser Tyr Thr Pro Pro Ala Gly Val Pro Gly Lys Pro Ala Ala
      25                  30                  35

 ccc cac ttc ctt cca gtg ctg tgc tct gtg tca cca tca ggc tcc agg      676
 Pro His Phe Leu Pro Val Leu Cys Ser Val Ser Pro Ser Gly Ser Arg
  40                  45                  50                  55

 gtc ccg cac gac ctc ctc ggg ggc tcc ggg ggc ttc acg ctg gag gac      724
 Val Pro His Asp Leu Leu Gly Gly Ser Gly Gly Phe Thr Leu Glu Asp
                  60                  65                  70

 gcc ctc ttc ggg ctc ctc ttt gga gct gat gcc acc ctc ctg cag tca      772
 Ala Leu Phe Gly Leu Leu Phe Gly Ala Asp Ala Thr Leu Leu Gln Ser
              75                  80                  85

 cct gtg gtc ctc tgt ggt ctc cct gat ggc cag ctc tgc tgt gtg atc      820
 Pro Val Val Leu Cys Gly Leu Pro Asp Gly Gln Leu Cys Cys Val Ile
          90                  95                 100

 ctg aag gcc ctg gtc acc tcc agg tca gcc cct ggt gac cca aat gcc      868
 Leu Lys Ala Leu Val Thr Ser Arg Ser Ala Pro Gly Asp Pro Asn Ala
     105                 110                 115

 ctt gtc aag atc ctc cat cac ctg gag gag ccc gtc atc ttc ata ggg      916
 Leu Val Lys Ile Leu His His Leu Glu Glu Pro Val Ile Phe Ile Gly
 120                 125                 130                 135

 gcc ttg aag aca gag cca cag gct gca gaa gct gca gag aat ttt ctg      964
 Ala Leu Lys Thr Glu Pro Gln Ala Ala Glu Ala Ala Glu Asn Phe Leu
                 140                 145                 150

 cct gac gag gat gtg cac tgt gac tgc ctg gtg gcc ttt ggt cac cac     1012
 Pro Asp Glu Asp Val His Cys Asp Cys Leu Val Ala Phe Gly His His
             155                 160                 165

 ggc cgg atg ctg gcc atc aag gcc agc tgg gat gag tcc ggg aag ctg     1060
 Gly Arg Met Leu Ala Ile Lys Ala Ser Trp Asp Glu Ser Gly Lys Leu
         170                 175                 180

 gtg ccc gag ctg cgg gag tac tgc ctc cca ggc cct gtg ctc tgc gct     1108
 Val Pro Glu Leu Arg Glu Tyr Cys Leu Pro Gly Pro Val Leu Cys Ala
     185                 190                 195

 gcc tgt ggc ggg ggt ggc cgc gtg tac cac agc acc cct tct gac ctc     1156
 Ala Cys Gly Gly Gly Gly Arg Val Tyr His Ser Thr Pro Ser Asp Leu
 200                 205                 210                 215

 tgt gtg gtg gat ctg tct cgg gga agc acc ccg ctg ggc cct gag cag     1204
 Cys Val Val Asp Leu Ser Arg Gly Ser Thr Pro Leu Gly Pro Glu Gln
                 220                 225                 230

 ccc gaa gaa ggc ccg gga ggc ctg ccc ccc atg ctg tgc cca gcc agc     1252
 Pro Glu Glu Gly Pro Gly Gly Leu Pro Pro Met Leu Cys Pro Ala Ser
             235                 240                 245

 ctg aac atc tgc agt gtc gtc tcg ctg tcc gcg tct ccc agg acg cat     1300
 Leu Asn Ile Cys Ser Val Val Ser Leu Ser Ala Ser Pro Arg Thr His
         250                 255                 260

 gaa ggt ggc acc aag ctc ctg gcc ctg tcc gcc aaa ggc cgc ctg atg     1348
 Glu Gly Gly Thr Lys Leu Leu Ala Leu Ser Ala Lys Gly Arg Leu Met
     265                 270                 275

 acc tgc agc ctg gac ctg gac tct gag atg cct ggc cca gcc agg atg     1396
 Thr Cys Ser Leu Asp Leu Asp Ser Glu Met Pro Gly Pro Ala Arg Met
 280                 285                 290                 295

 acc aca gag cag tgc agg tca gaa aat aaa gga gct gct gtc tgg aat     1444
 Thr Thr Glu Gln Cys Arg Ser Glu Asn Lys Gly Ala Ala Val Trp Asn
                 300                 305                 310

 tgg caa cat ctc tga gagagtgtct tttctaaaga aggcggttga ccagcggaac     1499
 Trp Gln His Leu 
             315

 aaggcactga caagcctcaa cgagggccat gaacgtgagc tgtgcactgc tgtcaagcgg   1559

 cacgggcccc agacccatct cctgcagcac cagcagcagc tggagccagc tgcagacaca   1619

 ggatgtgctc atggccacct gcgtgctaca gaacagcagc agcttcagcc ttggaccagg   1679

 ggtggaccct gtgacatcca ggtgtcacca gctcctgtgc ttctcgacct ggactcggct   1739

 gattccgacc atcaactacc acatccccgt ggaccattcg gcccggtgct cggaggaacg   1799

 gacgctaccc tgggacctgt gagaccgggg ttgatctgcc a                       1840




      <210> 329
      <211> 1156
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(917)

      <400> 329
 ggggcggcgg caatgccgga ccgcttcggc accgcccgcc cgatccctcc acccgtgggc     60

 cggca    atg gcg ggc gca gtt tcg ctc ttg ggt gtg gtg ggg ctg ctg     107
          Met Ala Gly Ala Val Ser Leu Leu Gly Val Val Gly Leu Leu
            1               5                  10

 ctt gtg tct gcg ctg tcc ggg gtc cta gga gac cgc gcc aat ccc gac      155
 Leu Val Ser Ala Leu Ser Gly Val Leu Gly Asp Arg Ala Asn Pro Asp
  15                  20                  25                  30

 ctc cgg gca cac cca ggg aac gca gcc cac ccc ggc tct gga gcc acg      203
 Leu Arg Ala His Pro Gly Asn Ala Ala His Pro Gly Ser Gly Ala Thr
                  35                  40                  45

 gaa ccc cgg cgg cga cca ccg ctc aag gat caa cgc gag cgg acc cgg      251
 Glu Pro Arg Arg Arg Pro Pro Leu Lys Asp Gln Arg Glu Arg Thr Arg
              50                  55                  60

 gcc ggg tcg ctg cct ctg ggg gcg ctg tac acc gcg gcc gtc gcg gct      299
 Ala Gly Ser Leu Pro Leu Gly Ala Leu Tyr Thr Ala Ala Val Ala Ala
          65                  70                  75

 ttt gtg ctg tac aag tgt ttg cag ggg aaa gat gaa act gcg gtt ctc      347
 Phe Val Leu Tyr Lys Cys Leu Gln Gly Lys Asp Glu Thr Ala Val Leu
      80                  85                  90

 cac gag gag gca agc aag cag cag cca ctg cag tca gag caa cag ctg      395
 His Glu Glu Ala Ser Lys Gln Gln Pro Leu Gln Ser Glu Gln Gln Leu
  95                 100                 105                 110

 gcc cag ttg aca caa cag ctg gcc cag aca gag cag cac ctg aac aac      443
 Ala Gln Leu Thr Gln Gln Leu Ala Gln Thr Glu Gln His Leu Asn Asn
                 115                 120                 125

 ctg atg gcc cag ctg gac ccc ctt ttt gag cgt gtg act act ctg gct      491
 Leu Met Ala Gln Leu Asp Pro Leu Phe Glu Arg Val Thr Thr Leu Ala
             130                 135                 140

 gga gcc cag cag gag ctt ctg aac atg aag cta tgg acc atc cac gag      539
 Gly Ala Gln Gln Glu Leu Leu Asn Met Lys Leu Trp Thr Ile His Glu
         145                 150                 155

 ctg ctg caa gat agc aag ccg gac aag gat atg gag gct tca gaa cca      587
 Leu Leu Gln Asp Ser Lys Pro Asp Lys Asp Met Glu Ala Ser Glu Pro
     160                 165                 170

 ggt gaa ggc tcg gga ggc gag tct gct gga ggt gga gac aaa gtc tct      635
 Gly Glu Gly Ser Gly Gly Glu Ser Ala Gly Gly Gly Asp Lys Val Ser
 175                 180                 185                 190

 gaa act gga aca ttc ctg atc tct ccc cac aca gag gcc agc aga cct      683
 Glu Thr Gly Thr Phe Leu Ile Ser Pro His Thr Glu Ala Ser Arg Pro
                 195                 200                 205

 ctt cct gag gac ttc tgt tta aag gag gac gag gag gag att ggt gac      731
 Leu Pro Glu Asp Phe Cys Leu Lys Glu Asp Glu Glu Glu Ile Gly Asp
             210                 215                 220

 agt cag gcc tgg gag gag ccc aca aac tgg agc aca gag aca tgg aac      779
 Ser Gln Ala Trp Glu Glu Pro Thr Asn Trp Ser Thr Glu Thr Trp Asn
         225                 230                 235

 cta gct act tcc tgg gag gtg ggg cgg gga cta cgg aga agg tgc agc      827
 Leu Ala Thr Ser Trp Glu Val Gly Arg Gly Leu Arg Arg Arg Cys Ser
     240                 245                 250

 cag gct gtg gca aag ggc ccc agt cac agc ctt ggc tgg gaa gga ggg      875
 Gln Ala Val Ala Lys Gly Pro Ser His Ser Leu Gly Trp Glu Gly Gly
 255                 260                 265                 270

 acg aca gct gaa ggt cga cta aaa caa agt ctg ttt tca tga tggagtg      924
 Thr Thr Ala Glu Gly Arg Leu Lys Gln Ser Leu Phe Ser 
                 275                 280

 ctcctgtgtg ttttttcgat cctagttggt tgtacacacc catactaggt gcctaaggac    984

 aactgggcct tcttgaagag ctgtccttat taggacaaaa agaggctgcc ttccagtgtg   1044

 acagcagaga agatagaggg agctccagct cttttcctcg tattcctgag ccaccagcat   1104

 gcccgcgttc aggcccaaat cccttcacac ccagcctcgt acctagacta at           1156




      <210> 330
      <211> 823
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (34)..(804)

      <400> 330
 cgcccgcccg atccctccac ccgtgggccg gca atg gcg ggc gca gtt tcg ctc      54
                                      Met Ala Gly Ala Val Ser Leu
                                        1               5

 ttg ggt gtg gtg ggg ctg ctg ctt gtg tct gcg ctg tcc ggg gtc cta      102
 Leu Gly Val Val Gly Leu Leu Leu Val Ser Ala Leu Ser Gly Val Leu
          10                  15                  20

 gga gac cgc gcc aat ccc gac ctc cgg gca cac cca ggg aac gca gcc      150
 Gly Asp Arg Ala Asn Pro Asp Leu Arg Ala His Pro Gly Asn Ala Ala
      25                  30                  35

 cac ccc ggc tct gga gcc acg gaa ccc cgg cgg cga cca ccg ctc aag      198
 His Pro Gly Ser Gly Ala Thr Glu Pro Arg Arg Arg Pro Pro Leu Lys
  40                  45                  50                  55

 gat caa cgc gag cgg acc cgg gcc ggg tcg ctg cct ctg ggg gcg ctg      246
 Asp Gln Arg Glu Arg Thr Arg Ala Gly Ser Leu Pro Leu Gly Ala Leu
                  60                  65                  70

 tac acc gcg gcc gtc gcg gct ttt gtg ctg tac aag tgt ttg cag ggg      294
 Tyr Thr Ala Ala Val Ala Ala Phe Val Leu Tyr Lys Cys Leu Gln Gly
              75                  80                  85

 aaa gat gaa act gcg gtt ctc cac gag gag gca agc aag cag cag cca      342
 Lys Asp Glu Thr Ala Val Leu His Glu Glu Ala Ser Lys Gln Gln Pro
          90                  95                 100

 ctg cag tca gag caa cag ctg gcc cag ttg aca caa cag ctg gcc cag      390
 Leu Gln Ser Glu Gln Gln Leu Ala Gln Leu Thr Gln Gln Leu Ala Gln
     105                 110                 115

 aca gag cag cac ctg aac aac ctg atg gcc cag ctg gac ccc ctt ttt      438
 Thr Glu Gln His Leu Asn Asn Leu Met Ala Gln Leu Asp Pro Leu Phe
 120                 125                 130                 135

 gag cgt gtg act act ctg gct gga gcc cag cag gag ctt ctg aac atg      486
 Glu Arg Val Thr Thr Leu Ala Gly Ala Gln Gln Glu Leu Leu Asn Met
                 140                 145                 150

 aag cta tgg acc atc cac gag ctg ctg caa gat agc aag ccg gac aag      534
 Lys Leu Trp Thr Ile His Glu Leu Leu Gln Asp Ser Lys Pro Asp Lys
             155                 160                 165

 gat atg gag gct tca gaa cca gag gcc agc aga cct ctt cct gag gac      582
 Asp Met Glu Ala Ser Glu Pro Glu Ala Ser Arg Pro Leu Pro Glu Asp
         170                 175                 180

 ttc tgt tta aag gag gac gag gag gag att ggt gac agt cag gcc tgg      630
 Phe Cys Leu Lys Glu Asp Glu Glu Glu Ile Gly Asp Ser Gln Ala Trp
     185                 190                 195

 gag gag ccc aca aac tgg agc aca gag aca tgg aac cta gct act tcc      678
 Glu Glu Pro Thr Asn Trp Ser Thr Glu Thr Trp Asn Leu Ala Thr Ser
 200                 205                 210                 215

 tgg gag gtg ggg cgg gga cta cgg aga agg tgc agc cag gct gtg gca      726
 Trp Glu Val Gly Arg Gly Leu Arg Arg Arg Cys Ser Gln Ala Val Ala
                 220                 225                 230

 aag ggc ccc agt cac agc ctt ggc tgg gaa gga ggg acg aca gct gaa      774
 Lys Gly Pro Ser His Ser Leu Gly Trp Glu Gly Gly Thr Thr Ala Glu
             235                 240                 245

 ggt cga cta aaa caa agt ctg ttt tca tga aaaaaaaaaa aaaaaaaaa         823
 Gly Arg Leu Lys Gln Ser Leu Phe Ser 
         250                 255





      <210> 331
      <211> 1053
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (188)..(691)

      <220>
      <221> misc_feature
      <222> (1)...(1053)
      <223> n = a,t,c or g

      <400> 331
 attgatggca gtcccaacng ctagtatagg agacccaagc tggctagcgt ttaaacttaa     60

 gcttggtacc gagctcggat ccactagtcc agtgtggtgg aattcgttga acggctgtgg    120

 gcgtcttgct gccttgggta gggggttaaa atcgttcttg agaggaacgt ctctgtgcga    180

 agagata  atg agt tta gct ctg aga agt gag ctt cta gtg gac aaa aca     229
          Met Ser Leu Ala Leu Arg Ser Glu Leu Leu Val Asp Lys Thr
            1               5                  10

 aag agg aaa aaa aga aga gaa ctg tct gag gaa cag aaa caa gaa att      277
 Lys Arg Lys Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile
  15                  20                  25                  30

 aaa gat gct ttt gaa cta ttt gat aca gac aaa gat gaa gca ata gat      325
 Lys Asp Ala Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp
                  35                  40                  45

 tat cat gaa tta aag gtg gca atg aga gcc ttg ggg ttt gat gta aaa      373
 Tyr His Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys
              50                  55                  60

 aaa gct gat gta ctg aag att ctt aaa gat tat gac aga gaa gcc aca      421
 Lys Ala Asp Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr
          65                  70                  75

 ggg aaa atc acc ttt gaa gat ttt aat gaa gtt gtg aca gac tgg ata      469
 Gly Lys Ile Thr Phe Glu Asp Phe Asn Glu Val Val Thr Asp Trp Ile
      80                  85                  90

 ttg gaa aga gat ccc cat gaa gaa ata ctc aag gca ttt aaa cta ttt      517
 Leu Glu Arg Asp Pro His Glu Glu Ile Leu Lys Ala Phe Lys Leu Phe
  95                 100                 105                 110

 gat gat gat gat tca ggt aaa ata agc ttg agg aat ttg cga cgt gtt      565
 Asp Asp Asp Asp Ser Gly Lys Ile Ser Leu Arg Asn Leu Arg Arg Val
                 115                 120                 125

 gct aga gaa ttg ggt gaa aac atg agt gat gaa gaa ctt cga gct atg      613
 Ala Arg Glu Leu Gly Glu Asn Met Ser Asp Glu Glu Leu Arg Ala Met
             130                 135                 140

 ata gaa gaa ttt gac aaa gat ggt gat gga gaa ata aac caa gag gag      661
 Ile Glu Glu Phe Asp Lys Asp Gly Asp Gly Glu Ile Asn Gln Glu Glu
         145                 150                 155

 ttc att gct att atg act ggt gac att taa a gaattacaag gataaacact      712
 Phe Ile Ala Ile Met Thr Gly Asp Ile 
     160                 165

 aagaatgttg cagttaccat cttatattct atttttgtgc ctggagccat gtgaaaaaaa    772

 ccaacttagt tcttttatcc taaaggacca aaaataagca tcttatatat ctgtatttta    832

 ctactgttaa gtttctttgt atgaactgtg ttgttagtac tcagatagtt tagctttgta    892

 tttataatag agcttttata taaagtttta aaaattgaat gtgtgatatg tgttctttga    952

 aggtttttta atttaacatt tatagtcact ttttagtgca cacattttcc agactttcgt   1012

 taataaaata tttattttat tagaatttta aaaaaaaaaa a                       1053




      <210> 332
      <211> 2015
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (294)..(1745)

      <400> 332
 gctgttcttc agcggctacg cgctcctgcc gggcgccgag cccgccgcgc actgctactg     60

 cggccaccaa ttcggccagt tcgccgggca gctgggcgac ggcgccgcca tgtacctggg    120

 cgaggtgtgc acggcgaacg gcgagcgctg ggagctgcag ctcaagggcg ccgggcccac    180

 gcccttctcc agaaagaaga tgctgatatg ctacaacacg gatgaacctg gaggacgtgg    240

 tgcagtgaaa taagctggtc acagagagac aaatcctggg tgatcccact tac   atg     296
                                                              Met
                                                                1

 aga cag gcc gac ggt cgc aag gtc cta cgg tca agc atc cgg gag ttt      344
 Arg Gln Ala Asp Gly Arg Lys Val Leu Arg Ser Ser Ile Arg Glu Phe
               5                  10                  15

 cta tgc agc gaa gcc atg ttc cac ctg gga gtc ccc acc aca cgg gcc      392
 Leu Cys Ser Glu Ala Met Phe His Leu Gly Val Pro Thr Thr Arg Ala
          20                  25                  30

 ggc gcc tgc gtc acg tcc gag tcc acg gtg gtg cgc gac gtg ttc tat      440
 Gly Ala Cys Val Thr Ser Glu Ser Thr Val Val Arg Asp Val Phe Tyr
      35                  40                  45

 gat ggt aat ccc aaa tat gaa caa tgc acg gtt gtg ttg cgt gta gct      488
 Asp Gly Asn Pro Lys Tyr Glu Gln Cys Thr Val Val Leu Arg Val Ala
  50                  55                  60                  65

 tcc act ttc ata agg ttt gga tcc ttt gag att ttt aag tct gca gat      536
 Ser Thr Phe Ile Arg Phe Gly Ser Phe Glu Ile Phe Lys Ser Ala Asp
                  70                  75                  80

 gag cac aca ggg cgt gca ggc ccc agc gtg ggg agg aac gac att cga      584
 Glu His Thr Gly Arg Ala Gly Pro Ser Val Gly Arg Asn Asp Ile Arg
              85                  90                  95

 gtg cag ctg ctc gac tat gtc atc agc tcc ttt tac ccc gag atc cag      632
 Val Gln Leu Leu Asp Tyr Val Ile Ser Ser Phe Tyr Pro Glu Ile Gln
         100                 105                 110

 gct gct cat gcc agc gac agc gtg cag aga aat gct gcc ttc ttc cgg      680
 Ala Ala His Ala Ser Asp Ser Val Gln Arg Asn Ala Ala Phe Phe Arg
     115                 120                 125

 gag gtg acg cgg cgc acg gcg cgg atg gtg gcc gag tgg cag tgt gtg      728
 Glu Val Thr Arg Arg Thr Ala Arg Met Val Ala Glu Trp Gln Cys Val
 130                 135                 140                 145

 ggc ttc tgc cac ggc gtg ctc aac acc gac aac atg agc atc ctg ggg      776
 Gly Phe Cys His Gly Val Leu Asn Thr Asp Asn Met Ser Ile Leu Gly
                 150                 155                 160

 ctc acc atc gac tac ggg ccc ttt ggc ttc ctg gac agg tac gac ccc      824
 Leu Thr Ile Asp Tyr Gly Pro Phe Gly Phe Leu Asp Arg Tyr Asp Pro
             165                 170                 175

 gac cac gtg tgc aat gcc tcc gac aac acc ggc cgc tac gcg tac agc      872
 Asp His Val Cys Asn Ala Ser Asp Asn Thr Gly Arg Tyr Ala Tyr Ser
         180                 185                 190

 aag cag ccc gag gtg tgc agg tgg aac ctg cgg aag ctg gcc gag gcc      920
 Lys Gln Pro Glu Val Cys Arg Trp Asn Leu Arg Lys Leu Ala Glu Ala
     195                 200                 205

 ctg cag ccg gaa ctg ccc ctg gag ctg ggg gag gcc atc ctg gcc gag      968
 Leu Gln Pro Glu Leu Pro Leu Glu Leu Gly Glu Ala Ile Leu Ala Glu
 210                 215                 220                 225

 gag ttt gac gcc gag ttc caa agg cac tac ctg cag aag atg cgc agg     1016
 Glu Phe Asp Ala Glu Phe Gln Arg His Tyr Leu Gln Lys Met Arg Arg
                 230                 235                 240

 aag ctg ggc ctc gtg cag gtg gag ctg gag gaa gac ggg gcg ctg gtg     1064
 Lys Leu Gly Leu Val Gln Val Glu Leu Glu Glu Asp Gly Ala Leu Val
             245                 250                 255

 tcc aag ctc ctg gag acc atg cat ctg acc ggt gcc gac ttc aca aac     1112
 Ser Lys Leu Leu Glu Thr Met His Leu Thr Gly Ala Asp Phe Thr Asn
         260                 265                 270

 acc ttc tac ttg ctg agc tcc ttc cca gtg gag cta gag tcg cca ggc     1160
 Thr Phe Tyr Leu Leu Ser Ser Phe Pro Val Glu Leu Glu Ser Pro Gly
     275                 280                 285

 ctg gcg gaa ttc ctg gcc agg ctg atg gag cag tgt gcc tcc ctg gag     1208
 Leu Ala Glu Phe Leu Ala Arg Leu Met Glu Gln Cys Ala Ser Leu Glu
 290                 295                 300                 305

 gag ctg agg ctg gcc ttc cgg ccc cag atg gat ccc cgg cag cta tcc     1256
 Glu Leu Arg Leu Ala Phe Arg Pro Gln Met Asp Pro Arg Gln Leu Ser
                 310                 315                 320

 atg atg ctg atg ctg gcg cag tca aac ccg cag ctg ttc gcg ctt atg     1304
 Met Met Leu Met Leu Ala Gln Ser Asn Pro Gln Leu Phe Ala Leu Met
             325                 330                 335

 ggc acc cgg gca ggc atc gcc agg gag ctg gag cgt gtg gag cag cag     1352
 Gly Thr Arg Ala Gly Ile Ala Arg Glu Leu Glu Arg Val Glu Gln Gln
         340                 345                 350

 tct cgg ctg gag cag ctg agt gcg gca gag ctg cag agc agg aac cag     1400
 Ser Arg Leu Glu Gln Leu Ser Ala Ala Glu Leu Gln Ser Arg Asn Gln
     355                 360                 365

 ggc cac tgg gct gac tgg cta cag gcg tac aga gcc cgg ctg gac aag     1448
 Gly His Trp Ala Asp Trp Leu Gln Ala Tyr Arg Ala Arg Leu Asp Lys
 370                 375                 380                 385

 gac ctg gaa ggc gct ggg gac gct gcc gcc tgg cag gct gag cac gtg     1496
 Asp Leu Glu Gly Ala Gly Asp Ala Ala Ala Trp Gln Ala Glu His Val
                 390                 395                 400

 cgc gtg atg cac gcc aac aac ccg aag tac gtg ctg agg aac tac atc     1544
 Arg Val Met His Ala Asn Asn Pro Lys Tyr Val Leu Arg Asn Tyr Ile
             405                 410                 415

 gcg cag aat gcc atc gag gct gcc gag cgc ggg gac ttc tca gag gtg     1592
 Ala Gln Asn Ala Ile Glu Ala Ala Glu Arg Gly Asp Phe Ser Glu Val
         420                 425                 430

 cgg cgg gtg ctg aaa cta ctg gag acc cct tac cac tgc gag gcg ggg     1640
 Arg Arg Val Leu Lys Leu Leu Glu Thr Pro Tyr His Cys Glu Ala Gly
     435                 440                 445

 gcc gcc aca gac gcc gag gcc acg gaa gcc gac ggg gcg gac ggc agg     1688
 Ala Ala Thr Asp Ala Glu Ala Thr Glu Ala Asp Gly Ala Asp Gly Arg
 450                 455                 460                 465

 cag cgc tcc tac agc agt aag ccc ccg ctc tgg gca gca gaa ctg tgc     1736
 Gln Arg Ser Tyr Ser Ser Lys Pro Pro Leu Trp Ala Ala Glu Leu Cys
                 470                 475                 480

 gtg aca tga tcttcgt aacggcctcg gcacgctcca cacccctgga gtctcccgag     1792
 Val Thr 


 gcccccatgt gctgctgagt ggccaagatg atgccaggct gccctataca ctgggggatt   1852

 ctgccctggc ccatgcacac ccgtctttcc atgatggcag agacatccag tcaggacctg   1912

 acccgtctct gtctgaggcc ggctcagcag tgcagcctgg tccctggggg ctggacccag   1972

 gctcctaaat aaaccagcaa ctccctcgaa aaaaaaaaaa aaa                     2015




      <210> 333
      <211> 2714
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2448)

      <400> 333
  atg gcc gta tac agg gca gcg ctc ggg gct tcg ctc gcg gct gcc cga      48
  Met Ala Val Tyr Arg Ala Ala Leu Gly Ala Ser Leu Ala Ala Ala Arg
    1               5                  10                  15

 ctc ttg ccc ctc ggt cgc tgt tcc ccg tcg ccg gcg ccc cgc tct acg       96
 Leu Leu Pro Leu Gly Arg Cys Ser Pro Ser Pro Ala Pro Arg Ser Thr
              20                  25                  30

 ttg tcg ggc gcc gcc atg gag ccc gcg cct cgc tgg ctg gcg ggg ctg      144
 Leu Ser Gly Ala Ala Met Glu Pro Ala Pro Arg Trp Leu Ala Gly Leu
          35                  40                  45

 cgc ttc gac aac cgc gcc ctg cgc gcc ctg ccc gtg gag gcg ccg ccg      192
 Arg Phe Asp Asn Arg Ala Leu Arg Ala Leu Pro Val Glu Ala Pro Pro
      50                  55                  60

 ccc ggt ccc gag ggc gcc ccg tcc gcg ccg cgg ccc gtg ccc ggg gcc      240
 Pro Gly Pro Glu Gly Ala Pro Ser Ala Pro Arg Pro Val Pro Gly Ala
  65                  70                  75                  80

 tgc ttc acc cgc gtg cag ccc acc ccg ctg cgg cag ccg cgc ctc gtg      288
 Cys Phe Thr Arg Val Gln Pro Thr Pro Leu Arg Gln Pro Arg Leu Val
                  85                  90                  95

 gcg ctg tca gag ccc gcg ctg gcg ttg ctg ggc ctg ggc gcg ccg ccc      336
 Ala Leu Ser Glu Pro Ala Leu Ala Leu Leu Gly Leu Gly Ala Pro Pro
             100                 105                 110

 gcg cgc gag gcc gag gcc gag gcc gcg ctg ttc ttc agc ggc aac gcg      384
 Ala Arg Glu Ala Glu Ala Glu Ala Ala Leu Phe Phe Ser Gly Asn Ala
         115                 120                 125

 ctc ctg ccg ggc gcc gag ccc gcc gcg cac tgc tac tgc ggc cac caa      432
 Leu Leu Pro Gly Ala Glu Pro Ala Ala His Cys Tyr Cys Gly His Gln
     130                 135                 140

 ttc ggc cag ttc gcc ggg cag ctg ggc gac ggc gcc gcc atg tac ctg      480
 Phe Gly Gln Phe Ala Gly Gln Leu Gly Asp Gly Ala Ala Met Tyr Leu
 145                 150                 155                 160

 ggc gag gtg tgc acg gcg acc ggc gag cgc tgg gag ctg cag ctc aag      528
 Gly Glu Val Cys Thr Ala Thr Gly Glu Arg Trp Glu Leu Gln Leu Lys
                 165                 170                 175

 ggc gcc ggg ccc acg ccc ttc tcc aga cag gcc gac ggt cgc aag gtc      576
 Gly Ala Gly Pro Thr Pro Phe Ser Arg Gln Ala Asp Gly Arg Lys Val
             180                 185                 190

 cta cgg tca agc atc cgg gag ttt cta tgc agc gaa gcc atg ttc cac      624
 Leu Arg Ser Ser Ile Arg Glu Phe Leu Cys Ser Glu Ala Met Phe His
         195                 200                 205

 ctg gga gtc ccc acc aca cgg gcc ggc gcc tgc gtc acg tcc gag tcc      672
 Leu Gly Val Pro Thr Thr Arg Ala Gly Ala Cys Val Thr Ser Glu Ser
     210                 215                 220

 acg gtg gtg cgc gac gtg ttc tat gat ggt aat ccc aaa tat gaa caa      720
 Thr Val Val Arg Asp Val Phe Tyr Asp Gly Asn Pro Lys Tyr Glu Gln
 225                 230                 235                 240

 tgc acg gtt gtg ttg cgt gta gct tcc act ttc ata agg ccc tcg ttg      768
 Cys Thr Val Val Leu Arg Val Ala Ser Thr Phe Ile Arg Pro Ser Leu
                 245                 250                 255

 cag cca gag atg gcc ctg cgg gag ctg gtg tgt ctc aaa gca cca gca      816
 Gln Pro Glu Met Ala Leu Arg Glu Leu Val Cys Leu Lys Ala Pro Ala
             260                 265                 270

 ggg ggc tcc agg gcc acg ggc acc aga gaa ggg tcc ctg cct ggt gct      864
 Gly Gly Ser Arg Ala Thr Gly Thr Arg Glu Gly Ser Leu Pro Gly Ala
         275                 280                 285

 tct ggg ggg gag ggg gtc cct gag cct gag gct ggg gac agt gtc cag      912
 Ser Gly Gly Glu Gly Val Pro Glu Pro Glu Ala Gly Asp Ser Val Gln
     290                 295                 300

 agc tgt ttg ctg gag ttt atg aca agg aac tac tta gac ttg act gag      960
 Ser Cys Leu Leu Glu Phe Met Thr Arg Asn Tyr Leu Asp Leu Thr Glu
 305                 310                 315                 320

 gaa atg gcc act gaa gaa gca gga gcc gca agc tgg gga tgg gaa aga     1008
 Glu Met Ala Thr Glu Glu Ala Gly Ala Ala Ser Trp Gly Trp Glu Arg
                 325                 330                 335

 tct ggg gcc acg act tcc tct gag gcc ccg ccc agc ggc aat gct ggc     1056
 Ser Gly Ala Thr Thr Ser Ser Glu Ala Pro Pro Ser Gly Asn Ala Gly
             340                 345                 350

 att gtt gtg aag tcc acc ctg tgt gca cac agc atc cct gcc ctg ggc     1104
 Ile Val Val Lys Ser Thr Leu Cys Ala His Ser Ile Pro Ala Leu Gly
         355                 360                 365

 ccg ctg gtt gcc agt agt aac ccc agt tgt gac aac gaa aaa tgt gtc     1152
 Pro Leu Val Ala Ser Ser Asn Pro Ser Cys Asp Asn Glu Lys Cys Val
     370                 375                 380

 cag acc ttg cct gat gtc ccc tgg ggg gca gtc acc ctg ggg gac ggc     1200
 Gln Thr Leu Pro Asp Val Pro Trp Gly Ala Val Thr Leu Gly Asp Gly
 385                 390                 395                 400

 tgc tgg ttt gga tcc ttt gag att ttt aag tct gca gat gag cac aca     1248
 Cys Trp Phe Gly Ser Phe Glu Ile Phe Lys Ser Ala Asp Glu His Thr
                 405                 410                 415

 ggg cgt gca ggc ccc agc gtg ggg agg aac gac att cga gtg cag ctg     1296
 Gly Arg Ala Gly Pro Ser Val Gly Arg Asn Asp Ile Arg Val Gln Leu
             420                 425                 430

 ctc gac tat gtc atc agc tcc ttt tac ccc gag atc cag gct gct cat     1344
 Leu Asp Tyr Val Ile Ser Ser Phe Tyr Pro Glu Ile Gln Ala Ala His
         435                 440                 445

 gcc agc gac agc gtg cag aga aat gct gcc ttc ttc cgg gag gtg acg     1392
 Ala Ser Asp Ser Val Gln Arg Asn Ala Ala Phe Phe Arg Glu Val Thr
     450                 455                 460

 cgg cgc acg gcg cgg atg gtg gcc gag tgg cag tgt gtg ggc ttc tgc     1440
 Arg Arg Thr Ala Arg Met Val Ala Glu Trp Gln Cys Val Gly Phe Cys
 465                 470                 475                 480

 cac ggc gtg ctc aac acc gac aac atg agc atc ctg ggg ctc acc atc     1488
 His Gly Val Leu Asn Thr Asp Asn Met Ser Ile Leu Gly Leu Thr Ile
                 485                 490                 495

 gac tac ggg ccc ttt ggc ttc ctg gac agg tac gac ccc gac cac gtg     1536
 Asp Tyr Gly Pro Phe Gly Phe Leu Asp Arg Tyr Asp Pro Asp His Val
             500                 505                 510

 tgc aat gcc tcc gac aac acc ggc cgc tac gcg tac agc aag cag ccc     1584
 Cys Asn Ala Ser Asp Asn Thr Gly Arg Tyr Ala Tyr Ser Lys Gln Pro
         515                 520                 525

 gag gtg tgc agg tgg aac ctg cgg aag ctg gcc gag gcc ctg cag ccg     1632
 Glu Val Cys Arg Trp Asn Leu Arg Lys Leu Ala Glu Ala Leu Gln Pro
     530                 535                 540

 gaa ctg ccc ctg gag ctg ggg gag gcc atc ctg gcc gag gag ttt gac     1680
 Glu Leu Pro Leu Glu Leu Gly Glu Ala Ile Leu Ala Glu Glu Phe Asp
 545                 550                 555                 560

 gcc gag ttc caa agg cac tac ctg cag aag atg cgc agg aag ctg ggc     1728
 Ala Glu Phe Gln Arg His Tyr Leu Gln Lys Met Arg Arg Lys Leu Gly
                 565                 570                 575

 ctc gtg cag gtg gag ctg gag gaa gac ggg gcg ctg gtg tcc aag ctc     1776
 Leu Val Gln Val Glu Leu Glu Glu Asp Gly Ala Leu Val Ser Lys Leu
             580                 585                 590

 ctg gag acc atg cat ctg acc ggt gcc gac ttc aca aac acc ttc tac     1824
 Leu Glu Thr Met His Leu Thr Gly Ala Asp Phe Thr Asn Thr Phe Tyr
         595                 600                 605

 ttg ctg agc tcc ttc cca gtg gag cta gag tcg cca ggc ctg gcg gaa     1872
 Leu Leu Ser Ser Phe Pro Val Glu Leu Glu Ser Pro Gly Leu Ala Glu
     610                 615                 620

 ttc ctg gcc agg ctg atg gag cag tgt gcc tcc ctg gag gag ctg agg     1920
 Phe Leu Ala Arg Leu Met Glu Gln Cys Ala Ser Leu Glu Glu Leu Arg
 625                 630                 635                 640

 ctg gcc ttc cgg ccc cag atg gat ccc cgg cag cta tcc atg atg ctg     1968
 Leu Ala Phe Arg Pro Gln Met Asp Pro Arg Gln Leu Ser Met Met Leu
                 645                 650                 655

 atg ctg gcg cag tca aac ccg cag ctg ttc gcg ctt atg ggc acc cgg     2016
 Met Leu Ala Gln Ser Asn Pro Gln Leu Phe Ala Leu Met Gly Thr Arg
             660                 665                 670

 gca ggc atc gcc agg gag ctg gag cgt gtg gag cag cag tct cgg ctg     2064
 Ala Gly Ile Ala Arg Glu Leu Glu Arg Val Glu Gln Gln Ser Arg Leu
         675                 680                 685

 gag cag ctg agt gcg gca gag ctg cag agc agg aac cag ggc cac tgg     2112
 Glu Gln Leu Ser Ala Ala Glu Leu Gln Ser Arg Asn Gln Gly His Trp
     690                 695                 700

 gct gac tgg cta cag gcg tac aga gcc cgg ctg gac aag gac ctg gaa     2160
 Ala Asp Trp Leu Gln Ala Tyr Arg Ala Arg Leu Asp Lys Asp Leu Glu
 705                 710                 715                 720

 ggc gct ggg gac gct gcc gcc tgg cag gct gag cac gtg cgc gtg atg     2208
 Gly Ala Gly Asp Ala Ala Ala Trp Gln Ala Glu His Val Arg Val Met
                 725                 730                 735

 cac gcc aac aac ccg aag tac gtg ctg agg aac tac atc gcg cag aat     2256
 His Ala Asn Asn Pro Lys Tyr Val Leu Arg Asn Tyr Ile Ala Gln Asn
             740                 745                 750

 gcc atc gag gct gcc gag cgc ggg gac ttc tca gag gtg cgg cgg gtg     2304
 Ala Ile Glu Ala Ala Glu Arg Gly Asp Phe Ser Glu Val Arg Arg Val
         755                 760                 765

 ctg aaa cta ctg gag acc cct tac cac tgc gag gcg ggg gcc gcc aca     2352
 Leu Lys Leu Leu Glu Thr Pro Tyr His Cys Glu Ala Gly Ala Ala Thr
     770                 775                 780

 gac gcc gag gcc acg gaa gcc gac ggg gcg gac ggc agg cag cgc tcc     2400
 Asp Ala Glu Ala Thr Glu Ala Asp Gly Ala Asp Gly Arg Gln Arg Ser
 785                 790                 795                 800

 tac agc agt aag ccc ccg ctc tgg gca gca gaa ctg tgc gtg aca tga     2448
 Tyr Ser Ser Lys Pro Pro Leu Trp Ala Ala Glu Leu Cys Val Thr 
                 805                 810                 815

 tcttcgtaac ggcctcggca cgctccacac ccctggagtc tcccgaggcc cccatgtgct   2508

 gctgagtggc caagatgatg ccaggctgcc ctatacactg ggggattctg ccctggccca   2568

 tgcacacccg tctttccatg atggcagaga catccagtca ggacctgacc cgtctctgtc   2628

 tgaggccggc tcagcagtgc agcctggtcc ctgggggctg gacccaggct cctaaataaa   2688

 ccagcaactc cctcgaaaaa aaaaaa                                        2714




      <210> 334
      <211> 2332
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (174)..(1589)

      <400> 334
 cccaagagca gctccaggct ggatctgcgc cggacacagg agaaagcagc gggtaggcta     60

 agcaggggtg ctgaggatgg aggaaagttg ggaggctgag cacagctgaa gtcctgagct    120

 ccctgtgccc ttgacttctc tgtgggctcg agcaaggacc atcccaactc agg   atg     176
                                                              Met
                                                                1

 aac cct cct tcg ggg cca aga gtc ccg ccc agc cca acc caa gag ccc      224
 Asn Pro Pro Ser Gly Pro Arg Val Pro Pro Ser Pro Thr Gln Glu Pro
               5                  10                  15

 agc tgc atg gcc acc cca gca cca ccc agc tgg tgg gac agc tcc cag      272
 Ser Cys Met Ala Thr Pro Ala Pro Pro Ser Trp Trp Asp Ser Ser Gln
          20                  25                  30

 agc agc atc tcc agc ctg ggc cgg ctt cca tcc atc agt ccc aca gca      320
 Ser Ser Ile Ser Ser Leu Gly Arg Leu Pro Ser Ile Ser Pro Thr Ala
      35                  40                  45

 cct ggg act tgg gct gct gcc tgg gtc ccc ctc ccc acg gtt gat gtt      368
 Pro Gly Thr Trp Ala Ala Ala Trp Val Pro Leu Pro Thr Val Asp Val
  50                  55                  60                  65

 cca gac cat gcc cac tat acc ctg ggc aca gtg atc ttg ctg gtg gga      416
 Pro Asp His Ala His Tyr Thr Leu Gly Thr Val Ile Leu Leu Val Gly
                  70                  75                  80

 ctc acg ggg atg ctg ggc aac ctg acg gtc atc tat acc ttc tgc agg      464
 Leu Thr Gly Met Leu Gly Asn Leu Thr Val Ile Tyr Thr Phe Cys Arg
              85                  90                  95

 agc aga agc ctc cgg aca cct gcc aac atg ttc att atc aac ctc gcg      512
 Ser Arg Ser Leu Arg Thr Pro Ala Asn Met Phe Ile Ile Asn Leu Ala
         100                 105                 110

 gtc agc gac ttc ctc atg tcc ttc acc cag gcc cct gtc ttc ttc acc      560
 Val Ser Asp Phe Leu Met Ser Phe Thr Gln Ala Pro Val Phe Phe Thr
     115                 120                 125

 agt agc ctc tat aag cag tgg ctc ttt ggg gag aca ggc tgc gag ttc      608
 Ser Ser Leu Tyr Lys Gln Trp Leu Phe Gly Glu Thr Gly Cys Glu Phe
 130                 135                 140                 145

 tat gcc ttc tgt gga gct ctc ttt ggc att tcc tcc atg atc acc ctg      656
 Tyr Ala Phe Cys Gly Ala Leu Phe Gly Ile Ser Ser Met Ile Thr Leu
                 150                 155                 160

 acg gcc atc gcc ctg gac cgc tac ctg gta atc aca cgc ccg ctg gcc      704
 Thr Ala Ile Ala Leu Asp Arg Tyr Leu Val Ile Thr Arg Pro Leu Ala
             165                 170                 175

 acc ttt ggt gtg gcg tcc aag agg cgt gcg gca ttt gtc ctg ctg ggc      752
 Thr Phe Gly Val Ala Ser Lys Arg Arg Ala Ala Phe Val Leu Leu Gly
         180                 185                 190

 gtt tgg ctc tat gcc ctg gcc tgg agt ctg cca ccc ttc ttc ggc tgg      800
 Val Trp Leu Tyr Ala Leu Ala Trp Ser Leu Pro Pro Phe Phe Gly Trp
     195                 200                 205

 agc gcc tac gtg ccc gag ggg ttg ctg aca tcc tgc tcc tgg gac tac      848
 Ser Ala Tyr Val Pro Glu Gly Leu Leu Thr Ser Cys Ser Trp Asp Tyr
 210                 215                 220                 225

 atg agc ttc acg ccg gcc gtg cgt gcc tac acc atg ctt ctc tgc tgc      896
 Met Ser Phe Thr Pro Ala Val Arg Ala Tyr Thr Met Leu Leu Cys Cys
                 230                 235                 240

 ttc gtg ttc ttc ctc cct ctg ctt atc atc atc tac tgc tac atc ttc      944
 Phe Val Phe Phe Leu Pro Leu Leu Ile Ile Ile Tyr Cys Tyr Ile Phe
             245                 250                 255

 atc ttc agg gcc atc cgg gag aca gga cgg gct ctc cag acc ttc ggg      992
 Ile Phe Arg Ala Ile Arg Glu Thr Gly Arg Ala Leu Gln Thr Phe Gly
         260                 265                 270

 gcc tgc aag ggc aat ggc gag tcc ctg tgg cag cgg cag cgg ctg cag     1040
 Ala Cys Lys Gly Asn Gly Glu Ser Leu Trp Gln Arg Gln Arg Leu Gln
     275                 280                 285

 agc gag tgc aag atg gcc aag atc atg ctg ctg gtc atc ctc ctc ttc     1088
 Ser Glu Cys Lys Met Ala Lys Ile Met Leu Leu Val Ile Leu Leu Phe
 290                 295                 300                 305

 gtg ctc tcc tgg gct ccc tat tcc gct gtg gcc ctg gtg gcc ttt gct     1136
 Val Leu Ser Trp Ala Pro Tyr Ser Ala Val Ala Leu Val Ala Phe Ala
                 310                 315                 320

 ggg tac gca cac gtc ctg aca ccc tac atg agc tcg gtg cca gcc gtc     1184
 Gly Tyr Ala His Val Leu Thr Pro Tyr Met Ser Ser Val Pro Ala Val
             325                 330                 335

 atc gcc aag gcc tct gca atc cac aac ccc atc att tac gcc atc acc     1232
 Ile Ala Lys Ala Ser Ala Ile His Asn Pro Ile Ile Tyr Ala Ile Thr
         340                 345                 350

 cac ccc aag tac agg gtg gcc att gcc cag cac ctg ccc tgc ctg ggg     1280
 His Pro Lys Tyr Arg Val Ala Ile Ala Gln His Leu Pro Cys Leu Gly
     355                 360                 365

 gtg ctg ctg ggt gta tca cgc cgg cac agt cgc ccc tac ccc agc tac     1328
 Val Leu Leu Gly Val Ser Arg Arg His Ser Arg Pro Tyr Pro Ser Tyr
 370                 375                 380                 385

 cgc tcc acc cac cgc tcc acg ctg acc agc cac acc tcc aac ctc agc     1376
 Arg Ser Thr His Arg Ser Thr Leu Thr Ser His Thr Ser Asn Leu Ser
                 390                 395                 400

 tgg atc tcc ata cgg agg cgc cag gag tcc ctg ggc tcg gag agt gag     1424
 Trp Ile Ser Ile Arg Arg Arg Gln Glu Ser Leu Gly Ser Glu Ser Glu
             405                 410                 415

 gtg ggg tgg gct gga cac aca tgg agg cag cag ctg tgt ggg gag ctg     1472
 Val Gly Trp Ala Gly His Thr Trp Arg Gln Gln Leu Cys Gly Glu Leu
         420                 425                 430

 ccc agc aag caa atg ggc ggt ccc tct acg gtc agg gtc tgg agg act     1520
 Pro Ser Lys Gln Met Gly Gly Pro Ser Thr Val Arg Val Trp Arg Thr
     435                 440                 445

 tgg aag cca agg cac ccc cca gac ccc agg gac acg aag cag aga ctc     1568
 Trp Lys Pro Arg His Pro Pro Asp Pro Arg Asp Thr Lys Gln Arg Leu
 450                 455                 460                 465

 cag gga aga cca agg ggc tga tc cccagccagg accccaggat gtagcacgac     1621
 Gln Gly Arg Pro Arg Gly 
                 470

 catcaggctc tccaggactt cgaagacaaa gcacacccca gaccccacgg acaccaagca   1681

 gagacaccag ggaagaccca ggattatgct gtgagcctgc aggctttgga agtggccctg   1741

 tcacccgtgc tgcacgggat tcacagcccc agccccatgg cccctctcca cacctcaaaa   1801

 ctcctgcccc ataacgtcct ccgcatccac tttccagctc agcagccgca cccgaggctc   1861

 agcctgaggg gtgtgtgccc aggccctccc acttcccgag ttgtctgcct ctcctcaaat   1921

 gctgtgtgct gcaattgtcc aggcgatgac aatggtgatg gctccagaga acacaccagc   1981

 tatttatgag cctctgcccc caggctgggc ctgtcactgg cataggaagg ccagccccgc   2041

 atctcccact gccaacagct gaagccgagc acagacctcc ctttgcacgc tggaacagtt   2101

 actcacctgt ggcttcttcc cccagtgtac cgttccactg tggcccacat tcttgtgcac   2161

 gcgggcattt gcaggcacgc tctcgcgtag ttacctatct gaatgcacac caagcacatg   2221

 cgtgcacact ctgcgtctgt gattcatttc atgtagtggt ctaagctcct cccagggctg   2281

 tgtggatctg acagggtata ggaaaataaa aagcggagaa ggtgtcttca g            2332




      <210> 335
      <211> 2438
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (168)..(2246)

      <400> 335
 gtgacttcag tttccgtccg ttccttccgc tggtgctaaa ataatctgat gccccacagc     60

 aaggaggtag cccagccccg cgttcggctg ctctcgagga ggccggagcc cccggagacg    120

 atgcgccccg cgagccgcct gcgcctgcgg gagcggctgc ccttgat  atg gag ttg     176
                                                      Met Glu Leu
                                                        1

 ctg cct ctt tgg ctc tgc ctg ggt ttt cac ttc ctg acc gtg ggc tgg      224
 Leu Pro Leu Trp Leu Cys Leu Gly Phe His Phe Leu Thr Val Gly Trp
       5                  10                  15

 agg aac aga agc gga aca gcc aca gca gcc tcc caa gga gtc tgc aag      272
 Arg Asn Arg Ser Gly Thr Ala Thr Ala Ala Ser Gln Gly Val Cys Lys
  20                  25                  30                  35

 ttg gtg ggt gga gcc gct gac tgc cga ggg cag agc ctc gct tcg gtg      320
 Leu Val Gly Gly Ala Ala Asp Cys Arg Gly Gln Ser Leu Ala Ser Val
                  40                  45                  50

 ccc agc agc ctc ccg ccc cac gcc cgg atg ctc acc ctg gat gcc aac      368
 Pro Ser Ser Leu Pro Pro His Ala Arg Met Leu Thr Leu Asp Ala Asn
              55                  60                  65

 cct ctc aag acc ctg tgg aat cac tcc ctc cag cct tac cct ctc ctg      416
 Pro Leu Lys Thr Leu Trp Asn His Ser Leu Gln Pro Tyr Pro Leu Leu
          70                  75                  80

 gag agc ctc agc ctg cac agc tgc cac ctg gag cgc atc agc cgc ggc      464
 Glu Ser Leu Ser Leu His Ser Cys His Leu Glu Arg Ile Ser Arg Gly
      85                  90                  95

 gcc ttc cag gag caa ggt cac ctg cgc agc ctg gtc ctg ggg gac aac      512
 Ala Phe Gln Glu Gln Gly His Leu Arg Ser Leu Val Leu Gly Asp Asn
 100                 105                 110                 115

 tgc ctc tca gag aac tac gaa gag acg gca gcc gcc ctc cac gcc ctg      560
 Cys Leu Ser Glu Asn Tyr Glu Glu Thr Ala Ala Ala Leu His Ala Leu
                 120                 125                 130

 ccg ggc ctg cgg agg ctg gac ttg tca gga aac gcc ctg acg gag gac      608
 Pro Gly Leu Arg Arg Leu Asp Leu Ser Gly Asn Ala Leu Thr Glu Asp
             135                 140                 145

 atg gca gcg ctc atg ctc cag aac ctc tcc tcg ctg cgg tcc gtg tcc      656
 Met Ala Ala Leu Met Leu Gln Asn Leu Ser Ser Leu Arg Ser Val Ser
         150                 155                 160

 ctg gcg ggg aac acc atc atg cgg ctg gac gac tcc gtc ttc gag ggc      704
 Leu Ala Gly Asn Thr Ile Met Arg Leu Asp Asp Ser Val Phe Glu Gly
     165                 170                 175

 ctg gag cgt ctc cgg gag ctg gat ctg cag agg aac tac atc ttc gag      752
 Leu Glu Arg Leu Arg Glu Leu Asp Leu Gln Arg Asn Tyr Ile Phe Glu
 180                 185                 190                 195

 atc gag ggc ggc gct ttc gac ggc ctg gct gag ctg agg cac ctc aac      800
 Ile Glu Gly Gly Ala Phe Asp Gly Leu Ala Glu Leu Arg His Leu Asn
                 200                 205                 210

 ctg gcc ttc aac aac ctc ccc tgc atc gtg gac ttc ggg ctc acg cgg      848
 Leu Ala Phe Asn Asn Leu Pro Cys Ile Val Asp Phe Gly Leu Thr Arg
             215                 220                 225

 ctg cgg gtc ctc aac gtc agc tac aac gtc ctg gag tgg ttc ctc gcg      896
 Leu Arg Val Leu Asn Val Ser Tyr Asn Val Leu Glu Trp Phe Leu Ala
         230                 235                 240

 acc ggg gga gag gct gcc ttc gag ctg gag acg ctg gac ctg tct cac      944
 Thr Gly Gly Glu Ala Ala Phe Glu Leu Glu Thr Leu Asp Leu Ser His
     245                 250                 255

 aac cag ctg ctg ttc ttc ccg ctg ctg ccc cag tac agc aag ttg cgg      992
 Asn Gln Leu Leu Phe Phe Pro Leu Leu Pro Gln Tyr Ser Lys Leu Arg
 260                 265                 270                 275

 acc ctc ctg ctg cgc gac aac aac atg ggc ttc tac cgg gac ctg tac     1040
 Thr Leu Leu Leu Arg Asp Asn Asn Met Gly Phe Tyr Arg Asp Leu Tyr
                 280                 285                 290

 aac acc tcg tcg ccg agg gag atg gtg gcc cag ttc ctc ctc gtg gac     1088
 Asn Thr Ser Ser Pro Arg Glu Met Val Ala Gln Phe Leu Leu Val Asp
             295                 300                 305

 ggc aac gtg acc aac atc acc acc gtc agc ctc tgg gaa gaa ttc tcc     1136
 Gly Asn Val Thr Asn Ile Thr Thr Val Ser Leu Trp Glu Glu Phe Ser
         310                 315                 320

 tcc agc gac ctc gca gat ctc cgc ttc ctg gac atg agc cag aac cag     1184
 Ser Ser Asp Leu Ala Asp Leu Arg Phe Leu Asp Met Ser Gln Asn Gln
     325                 330                 335

 ttc cag tac ctg cca gac ggc ttc ctg agg aaa atg cct tcc ctc tcc     1232
 Phe Gln Tyr Leu Pro Asp Gly Phe Leu Arg Lys Met Pro Ser Leu Ser
 340                 345                 350                 355

 cac ctg aac ctc cac cag aat tgc ctg atg acg ctt cac att cgg gag     1280
 His Leu Asn Leu His Gln Asn Cys Leu Met Thr Leu His Ile Arg Glu
                 360                 365                 370

 cac gag ccc ccc gga gcg ctc acc gag ctg gac ctg agc cac aac cag     1328
 His Glu Pro Pro Gly Ala Leu Thr Glu Leu Asp Leu Ser His Asn Gln
             375                 380                 385

 ctg tcg gag ctg cac ctg gct ccg ggg ctg gcc agc tgc ctg ggc agc     1376
 Leu Ser Glu Leu His Leu Ala Pro Gly Leu Ala Ser Cys Leu Gly Ser
         390                 395                 400

 ctg cgc ttg ttc aac ctg agc tcc aac cag ctc ctg ggc gtc ccc cct     1424
 Leu Arg Leu Phe Asn Leu Ser Ser Asn Gln Leu Leu Gly Val Pro Pro
     405                 410                 415

 ggc ctc ttc gcc aat gct agg aac atc act aca ctt gac atg agc cac     1472
 Gly Leu Phe Ala Asn Ala Arg Asn Ile Thr Thr Leu Asp Met Ser His
 420                 425                 430                 435

 aat cag atc tca ctt tgt ccc ctg cca gct gcc tcg gac cgg gtg ggc     1520
 Asn Gln Ile Ser Leu Cys Pro Leu Pro Ala Ala Ser Asp Arg Val Gly
                 440                 445                 450

 ccc cct agc tgt gtg gat ttc agg aat atg gca tct tta agg agc ctg     1568
 Pro Pro Ser Cys Val Asp Phe Arg Asn Met Ala Ser Leu Arg Ser Leu
             455                 460                 465

 tct ctg gag ggc tgt ggc ctg ggg gca ttg cca gac tgc cca ttc caa     1616
 Ser Leu Glu Gly Cys Gly Leu Gly Ala Leu Pro Asp Cys Pro Phe Gln
         470                 475                 480

 ggg acc tcc ctg acc tac tta gac ctc tca agc aac tgg ggg gtt ctg     1664
 Gly Thr Ser Leu Thr Tyr Leu Asp Leu Ser Ser Asn Trp Gly Val Leu
     485                 490                 495

 aat ggg agc ctc gcc cca ctc cag gat gtt gcc ccc atg tta cag gtc     1712
 Asn Gly Ser Leu Ala Pro Leu Gln Asp Val Ala Pro Met Leu Gln Val
 500                 505                 510                 515

 ctg tct ctc agg aac atg ggc ctc cac tcc agc ttt atg gcg ttg gac     1760
 Leu Ser Leu Arg Asn Met Gly Leu His Ser Ser Phe Met Ala Leu Asp
                 520                 525                 530

 ttc tct ggg ttt ggg aat ctc agg gac tta gat ctg tcg ggg aat tgc     1808
 Phe Ser Gly Phe Gly Asn Leu Arg Asp Leu Asp Leu Ser Gly Asn Cys
             535                 540                 545

 ttg ccc atc ttc cca agg ttt ggg ggc agc ctg gcc ctg gag acc ctg     1856
 Leu Pro Ile Phe Pro Arg Phe Gly Gly Ser Leu Ala Leu Glu Thr Leu
         550                 555                 560

 gat ctc cgt aga aac tcg ctc aca gcc ctt ccc cag aag gct gtg tct     1904
 Asp Leu Arg Arg Asn Ser Leu Thr Ala Leu Pro Gln Lys Ala Val Ser
     565                 570                 575

 gag cag ctc tcg aga ggt ctg cgg acc atc tac ctc agt cag aat cca     1952
 Glu Gln Leu Ser Arg Gly Leu Arg Thr Ile Tyr Leu Ser Gln Asn Pro
 580                 585                 590                 595

 tat gac tgc tgt ggg gtg gat ggc tgg ggg gcc ctg cag cat ggg cag     2000
 Tyr Asp Cys Cys Gly Val Asp Gly Trp Gly Ala Leu Gln His Gly Gln
                 600                 605                 610

 acg gtg gcc gac tgg gcc atg gtc acc tgc aac ctc tcc tcc aag atc     2048
 Thr Val Ala Asp Trp Ala Met Val Thr Cys Asn Leu Ser Ser Lys Ile
             615                 620                 625

 atc cgc gtg acg gag ctg ccc gga ggt gtg cct cgg gac tgc aag tgg     2096
 Ile Arg Val Thr Glu Leu Pro Gly Gly Val Pro Arg Asp Cys Lys Trp
         630                 635                 640

 gag cgg ctg gac ctg ggc ctg ctc tac ctc gtg ctc atc ctc ccc agc     2144
 Glu Arg Leu Asp Leu Gly Leu Leu Tyr Leu Val Leu Ile Leu Pro Ser
     645                 650                 655

 tgc ctc acc ctg ctg gtg gcc tgc act gtc atc gtc ctc act ttt aag     2192
 Cys Leu Thr Leu Leu Val Ala Cys Thr Val Ile Val Leu Thr Phe Lys
 660                 665                 670                 675

 aag cct ctg ctt cag gtc atc aag agc cgc tgc cac tgg tcc tcc gtt     2240
 Lys Pro Leu Leu Gln Val Ile Lys Ser Arg Cys His Trp Ser Ser Val
                 680                 685                 690

 tac tga cctggctgtg tgccaagact cgaaattcgg tccgcacaca acaggacact      2296
 Tyr 


 ttctctgcca gctttcaaga tgtgatgcag aggccaagtc tgacgaattg aagtttcaat   2356

 taaaatctaa tatgtttcca taactcatct gcccacacca cgcatgtatt cggccgctct   2416

 agaggatcct tgcctaagtc ga                                            2438




      <210> 336
      <211> 1174
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (156)..(923)

      <400> 336
 ggattgtggc taccatttgg accctggtag aaccatggac agcgggttgt acagtcttta     60

 tccaccatct gccacagttt gacaccaagg tcatcataca gacattgttg aaatacccca    120

 ttaaccactt ttggggggta tcatctatat atcga   atg att ctg cag cag gat     173
                                          Met Ile Leu Gln Gln Asp
                                            1               5

 ttc acc agc atc agg ttc cct gcc ctg gag cac tgc tat act ggc ggg      221
 Phe Thr Ser Ile Arg Phe Pro Ala Leu Glu His Cys Tyr Thr Gly Gly
              10                  15                  20

 gag gtc gtg ttg ccc aag gat cag gag gag tgg aaa aga cgg acg ggc      269
 Glu Val Val Leu Pro Lys Asp Gln Glu Glu Trp Lys Arg Arg Thr Gly
          25                  30                  35

 ctt ctg ctc tac gag aac tat ggg cag tcg gaa acg gga cta att tgt      317
 Leu Leu Leu Tyr Glu Asn Tyr Gly Gln Ser Glu Thr Gly Leu Ile Cys
      40                  45                  50

 gcc acc tac tgg gga atg aag atc aag ccg ggt ttc atg ggg aag gcc      365
 Ala Thr Tyr Trp Gly Met Lys Ile Lys Pro Gly Phe Met Gly Lys Ala
  55                  60                  65                  70

 act cca ccc tac gac gtc cag gtc att gat gac aag ggc agc atc ctg      413
 Thr Pro Pro Tyr Asp Val Gln Val Ile Asp Asp Lys Gly Ser Ile Leu
                  75                  80                  85

 cca cct aac aca gaa gga aac att ggc atc aga atc aaa cct gtc agg      461
 Pro Pro Asn Thr Glu Gly Asn Ile Gly Ile Arg Ile Lys Pro Val Arg
              90                  95                 100

 cct gtg agc ctc ttc atg tgc tat gag ggt gac cca gag aag aca gct      509
 Pro Val Ser Leu Phe Met Cys Tyr Glu Gly Asp Pro Glu Lys Thr Ala
         105                 110                 115

 aaa gtg gaa tgt ggg gac ttc tac aac act ggg gac aga gga aag atg      557
 Lys Val Glu Cys Gly Asp Phe Tyr Asn Thr Gly Asp Arg Gly Lys Met
     120                 125                 130

 gat gaa gag ggc tac att tgt ttc ctg ggg agg agt gat gac atc att      605
 Asp Glu Glu Gly Tyr Ile Cys Phe Leu Gly Arg Ser Asp Asp Ile Ile
 135                 140                 145                 150

 aat gcc tct ggg tat cgc atc ggg cct gca gag gtt gaa agc gct ttg      653
 Asn Ala Ser Gly Tyr Arg Ile Gly Pro Ala Glu Val Glu Ser Ala Leu
                 155                 160                 165

 gtg gag cac cca gcg gtg gcg gag tca gcc gtg gtg ggc agc cca gac      701
 Val Glu His Pro Ala Val Ala Glu Ser Ala Val Val Gly Ser Pro Asp
             170                 175                 180

 ccg att cga ggg gag gtg gtg aag gcc ttt att gtc ctg acc cca cag      749
 Pro Ile Arg Gly Glu Val Val Lys Ala Phe Ile Val Leu Thr Pro Gln
         185                 190                 195

 ttc ctg tcc cat gac aag gat cag ctg acc aag gaa ctg cag cag cat      797
 Phe Leu Ser His Asp Lys Asp Gln Leu Thr Lys Glu Leu Gln Gln His
     200                 205                 210

 gtc aag tca gtg aca gcc cca tac aag tac cca agg aag gtg gag ttt      845
 Val Lys Ser Val Thr Ala Pro Tyr Lys Tyr Pro Arg Lys Val Glu Phe
 215                 220                 225                 230

 gtc tca gag ctg cca aaa acc atc act ggc aag att gaa cgg aag gaa      893
 Val Ser Glu Leu Pro Lys Thr Ile Thr Gly Lys Ile Glu Arg Lys Glu
                 235                 240                 245

 ctt cgg aaa aag gag act ggt cag atg taa t cggcagtgaa ctcagaacgc      944
 Leu Arg Lys Lys Glu Thr Gly Gln Met 
             250                 255

 actgcacacc tgaggcaaat ccctggccac tttagtctcc ccactatggt gaggacgagg   1004

 gtggggcatt gagagtgttg atttgggaaa gtatcaggag tgccatgatt ccaatgtttt   1064

 ccttctttta aattaaattc agttgctctg cttcctccaa gtcctctgta tctttagaat   1124

 ttcccaggtg agcactcata acgcaagtaa taaaatactg atatcaacaa              1174




      <210> 337
      <211> 6384
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(3684)

      <400> 337
 ggcacgagct gtaggagcag gggcctagca agcgcccagc ggagcgaccc ctgcctggcc     60

 gtggctagc    atg gcc cct acg ctg ttc cag aag ctc ttc agc aag agg     108
              Met Ala Pro Thr Leu Phe Gln Lys Leu Phe Ser Lys Arg
                1               5                  10

 acc ggg ctg ggc gcg ccc ggc cgc gac gcc cgg gac cca gat tgc ggg      156
 Thr Gly Leu Gly Ala Pro Gly Arg Asp Ala Arg Asp Pro Asp Cys Gly
      15                  20                  25

 ttc agt tgg cct tta cca gag ttt gat cca agc cag att cga ctg att      204
 Phe Ser Trp Pro Leu Pro Glu Phe Asp Pro Ser Gln Ile Arg Leu Ile
  30                  35                  40                  45

 gta tat caa gac tgt gaa aga cga ggg aga aat gtt ttg ttt gac tcc      252
 Val Tyr Gln Asp Cys Glu Arg Arg Gly Arg Asn Val Leu Phe Asp Ser
                  50                  55                  60

 agt gtt aag aga aga aat gag gac ata tca gta tcg gac tta aat act      300
 Ser Val Lys Arg Arg Asn Glu Asp Ile Ser Val Ser Asp Leu Asn Thr
              65                  70                  75

 att tat tct tat ctt cat gga atg gaa ata tta tca aat ctc agg gaa      348
 Ile Tyr Ser Tyr Leu His Gly Met Glu Ile Leu Ser Asn Leu Arg Glu
          80                  85                  90

 cat cag ctt aga tta atg tct gca aga gca cgc tat gag aga tac agt      396
 His Gln Leu Arg Leu Met Ser Ala Arg Ala Arg Tyr Glu Arg Tyr Ser
      95                 100                 105

 ggc aat cag gtt ctc ttt tgt tca gaa acg att gcc aga tgt tgg tat      444
 Gly Asn Gln Val Leu Phe Cys Ser Glu Thr Ile Ala Arg Cys Trp Tyr
 110                 115                 120                 125

 atc cta ctt tct gga tct gtg ctt gtg aaa ggc tcc atg gtc ttg cct      492
 Ile Leu Leu Ser Gly Ser Val Leu Val Lys Gly Ser Met Val Leu Pro
                 130                 135                 140

 cct tgc agt ttt ggt aag cag ttt gga gga aaa aga gga tgt gat tgt      540
 Pro Cys Ser Phe Gly Lys Gln Phe Gly Gly Lys Arg Gly Cys Asp Cys
             145                 150                 155

 ctt gta tta gag cct tca gaa atg att gtg gta gag aat gcc aaa gat      588
 Leu Val Leu Glu Pro Ser Glu Met Ile Val Val Glu Asn Ala Lys Asp
         160                 165                 170

 aat gaa gat agt att cta caa aga gaa att cct gcc aga caa tcc cga      636
 Asn Glu Asp Ser Ile Leu Gln Arg Glu Ile Pro Ala Arg Gln Ser Arg
     175                 180                 185

 aga aga ttt cgg aaa att aac tat aaa gga gag cgc caa acc att act      684
 Arg Arg Phe Arg Lys Ile Asn Tyr Lys Gly Glu Arg Gln Thr Ile Thr
 190                 195                 200                 205

 gat gat gtg gag gtt aac agc tat ctt tct ctt cca gct gat ctt acc      732
 Asp Asp Val Glu Val Asn Ser Tyr Leu Ser Leu Pro Ala Asp Leu Thr
                 210                 215                 220

 aag atg cat ctc aca gaa aac cct cat cca cag gtg act cat gtg tct      780
 Lys Met His Leu Thr Glu Asn Pro His Pro Gln Val Thr His Val Ser
             225                 230                 235

 tct agt cag tct ggt tgt agc att gcc agt gac tct gga agc agc agt      828
 Ser Ser Gln Ser Gly Cys Ser Ile Ala Ser Asp Ser Gly Ser Ser Ser
         240                 245                 250

 tta tct gat atc tat cag gct acg gag agt gag gta gga gat gta gat      876
 Leu Ser Asp Ile Tyr Gln Ala Thr Glu Ser Glu Val Gly Asp Val Asp
     255                 260                 265

 ttg aca cgt ctt cca gaa gga cct gtt gat tct gag gat gac gaa gag      924
 Leu Thr Arg Leu Pro Glu Gly Pro Val Asp Ser Glu Asp Asp Glu Glu
 270                 275                 280                 285

 gaa gat gaa gag att gat cga aca gat cca ttg cag ggg cga gat ctt      972
 Glu Asp Glu Glu Ile Asp Arg Thr Asp Pro Leu Gln Gly Arg Asp Leu
                 290                 295                 300

 gtt cga gaa tgt ctt gaa aaa gaa cct gca gac aaa act gat gat gac     1020
 Val Arg Glu Cys Leu Glu Lys Glu Pro Ala Asp Lys Thr Asp Asp Asp
             305                 310                 315

 att gaa caa ttg ctg gag ttt atg cac cag ctc cct gca ttt gca aac     1068
 Ile Glu Gln Leu Leu Glu Phe Met His Gln Leu Pro Ala Phe Ala Asn
         320                 325                 330

 atg acc atg tct gta agg aga gaa ctc tgc tca gtg atg att ttt gaa     1116
 Met Thr Met Ser Val Arg Arg Glu Leu Cys Ser Val Met Ile Phe Glu
     335                 340                 345

 gtg gta gag cag gct gga gct att att ctt gaa gat ggg caa gag ctt     1164
 Val Val Glu Gln Ala Gly Ala Ile Ile Leu Glu Asp Gly Gln Glu Leu
 350                 355                 360                 365

 gac tca tgg tat gtt att tta aac ggc act gtg gaa atc agt cat cca     1212
 Asp Ser Trp Tyr Val Ile Leu Asn Gly Thr Val Glu Ile Ser His Pro
                 370                 375                 380

 gat gga aaa gtt gaa aat ttg ttt atg gga aat agt ttt gga att act     1260
 Asp Gly Lys Val Glu Asn Leu Phe Met Gly Asn Ser Phe Gly Ile Thr
             385                 390                 395

 ccc act ctg gat aag cag tac atg cat gga att gtc agg act aaa gta     1308
 Pro Thr Leu Asp Lys Gln Tyr Met His Gly Ile Val Arg Thr Lys Val
         400                 405                 410

 gat gat tgt cag ttt gtc tgc ata gcc cag caa gat tat tgg aga att     1356
 Asp Asp Cys Gln Phe Val Cys Ile Ala Gln Gln Asp Tyr Trp Arg Ile
     415                 420                 425

 tta aac cat gtg gaa aaa aat acc cat aaa gtt gag gaa gag gga gaa     1404
 Leu Asn His Val Glu Lys Asn Thr His Lys Val Glu Glu Glu Gly Glu
 430                 435                 440                 445

 att gtt atg gta cat gag cat cgg gaa cta gac cgg agt gga acc agg     1452
 Ile Val Met Val His Glu His Arg Glu Leu Asp Arg Ser Gly Thr Arg
                 450                 455                 460

 aaa gga cac att gtg atc aag gca aca cct gag cgt ctc ata atg cat     1500
 Lys Gly His Ile Val Ile Lys Ala Thr Pro Glu Arg Leu Ile Met His
             465                 470                 475

 tta ata gaa gaa cat tcc atc gtg gat cca act tat ata gaa gat ttt     1548
 Leu Ile Glu Glu His Ser Ile Val Asp Pro Thr Tyr Ile Glu Asp Phe
         480                 485                 490

 cta tta act tac agg aca ttt ctt gaa agt cct ttg gat gtt ggg atc     1596
 Leu Leu Thr Tyr Arg Thr Phe Leu Glu Ser Pro Leu Asp Val Gly Ile
     495                 500                 505

 aaa cta ttg gaa tgg ttt aag atc gac agc tta aga gat aag gtg aca     1644
 Lys Leu Leu Glu Trp Phe Lys Ile Asp Ser Leu Arg Asp Lys Val Thr
 510                 515                 520                 525

 cgg att gta tta tta tgg gta aat aat cat ttt aat gat ttt gaa ggt     1692
 Arg Ile Val Leu Leu Trp Val Asn Asn His Phe Asn Asp Phe Glu Gly
                 530                 535                 540

 gac cct gct atg act cga ttt cta gag gaa ttt gaa aaa aat ctg gaa     1740
 Asp Pro Ala Met Thr Arg Phe Leu Glu Glu Phe Glu Lys Asn Leu Glu
             545                 550                 555

 gat aca aag atg aat ggt cat ctc cgg tta ttg aat att gcc tgt gct     1788
 Asp Thr Lys Met Asn Gly His Leu Arg Leu Leu Asn Ile Ala Cys Ala
         560                 565                 570

 gca aag gct aag tgg aga cag gtt gtg ctg caa aag gct tcc cgc gag     1836
 Ala Lys Ala Lys Trp Arg Gln Val Val Leu Gln Lys Ala Ser Arg Glu
     575                 580                 585

 tcc cct cta caa ttc agc ctt aat gga ggg agt gag aag gga ttt ggt     1884
 Ser Pro Leu Gln Phe Ser Leu Asn Gly Gly Ser Glu Lys Gly Phe Gly
 590                 595                 600                 605

 att ttt gtt gaa gga gta gaa cct ggt agc aaa gct gct gat tca gga     1932
 Ile Phe Val Glu Gly Val Glu Pro Gly Ser Lys Ala Ala Asp Ser Gly
                 610                 615                 620

 ctg aaa cgt ggt gat cag att atg gaa gta aat gga caa aac ttt gag     1980
 Leu Lys Arg Gly Asp Gln Ile Met Glu Val Asn Gly Gln Asn Phe Glu
             625                 630                 635

 aat att aca ttt atg aaa gcc gtt gaa att ttg agg aat aat act cat     2028
 Asn Ile Thr Phe Met Lys Ala Val Glu Ile Leu Arg Asn Asn Thr His
         640                 645                 650

 ctt gca ctt act gtg aag acc aac att ttt gtg ttc aaa gag tta ctt     2076
 Leu Ala Leu Thr Val Lys Thr Asn Ile Phe Val Phe Lys Glu Leu Leu
     655                 660                 665

 ttt agg act gaa caa gag aaa tct ggt gtt cct cat att ccc aaa att     2124
 Phe Arg Thr Glu Gln Glu Lys Ser Gly Val Pro His Ile Pro Lys Ile
 670                 675                 680                 685

 gct gaa aaa aaa agt aat cgc cat tct atc cag cat gtg cca gga gat     2172
 Ala Glu Lys Lys Ser Asn Arg His Ser Ile Gln His Val Pro Gly Asp
                 690                 695                 700

 att gaa cag aca tca cag gag aaa gga agt aag aaa gtt aaa gca aat     2220
 Ile Glu Gln Thr Ser Gln Glu Lys Gly Ser Lys Lys Val Lys Ala Asn
             705                 710                 715

 act gtt tca ggt gga aga aac aaa atc agg aag att ttg gat aaa aca     2268
 Thr Val Ser Gly Gly Arg Asn Lys Ile Arg Lys Ile Leu Asp Lys Thr
         720                 725                 730

 cga ttt agt atc ttg cct cca aag cta ttt agt gat gga ggc cta agc     2316
 Arg Phe Ser Ile Leu Pro Pro Lys Leu Phe Ser Asp Gly Gly Leu Ser
     735                 740                 745

 caa tca caa gat gac agc att gtg gga aca agg cac tgt agg cat agt     2364
 Gln Ser Gln Asp Asp Ser Ile Val Gly Thr Arg His Cys Arg His Ser
 750                 755                 760                 765

 ctg gct ata atg ccc atc cct gga aca ctc tca tcc agc agc cct gat     2412
 Leu Ala Ile Met Pro Ile Pro Gly Thr Leu Ser Ser Ser Ser Pro Asp
                 770                 775                 780

 ctc ctg cag cct acc acc agt atg ttg gat ttt tcc aat cct tca gat     2460
 Leu Leu Gln Pro Thr Thr Ser Met Leu Asp Phe Ser Asn Pro Ser Asp
             785                 790                 795

 atc cct gat caa gtt ata aga gtt ttc aaa gtg gat cag caa agt tgc     2508
 Ile Pro Asp Gln Val Ile Arg Val Phe Lys Val Asp Gln Gln Ser Cys
         800                 805                 810

 tac att atc atc agt aaa gac acc aca gct aaa gaa gta gtt ttt cat     2556
 Tyr Ile Ile Ile Ser Lys Asp Thr Thr Ala Lys Glu Val Val Phe His
     815                 820                 825

 gct gtt cat gaa ttt ggt ttg acc ggt gca tcc gac aca tat tct ctc     2604
 Ala Val His Glu Phe Gly Leu Thr Gly Ala Ser Asp Thr Tyr Ser Leu
 830                 835                 840                 845

 tgt gaa gtt tct gtt act cct gag ggt gtc ata aaa cag aga aga ctt     2652
 Cys Glu Val Ser Val Thr Pro Glu Gly Val Ile Lys Gln Arg Arg Leu
                 850                 855                 860

 cca gat cag ttc tcc aaa tta gct gat aga att caa ctc aat gga agg     2700
 Pro Asp Gln Phe Ser Lys Leu Ala Asp Arg Ile Gln Leu Asn Gly Arg
             865                 870                 875

 tat tac tta aaa aat aac atg gaa aca gaa acc tta tgt tca gat gaa     2748
 Tyr Tyr Leu Lys Asn Asn Met Glu Thr Glu Thr Leu Cys Ser Asp Glu
         880                 885                 890

 gat gct caa gaa cta gtt aag gaa agc cag cta tcc atg ctg cag ctc     2796
 Asp Ala Gln Glu Leu Val Lys Glu Ser Gln Leu Ser Met Leu Gln Leu
     895                 900                 905

 agt acc att gag gtg gcc acc cag ctg tca atg agg gac ttt gat ttg     2844
 Ser Thr Ile Glu Val Ala Thr Gln Leu Ser Met Arg Asp Phe Asp Leu
 910                 915                 920                 925

 ttt cgt aat att gaa ccg act gag tac atc gat gac ctt ttt aag tta     2892
 Phe Arg Asn Ile Glu Pro Thr Glu Tyr Ile Asp Asp Leu Phe Lys Leu
                 930                 935                 940

 aat tcc aaa aca gga aat act cat ttg aag agg ttt gag gac att gta     2940
 Asn Ser Lys Thr Gly Asn Thr His Leu Lys Arg Phe Glu Asp Ile Val
             945                 950                 955

 aac caa gag aca ttc tgg gtt gcc tca gaa att tta act gaa gca aat     2988
 Asn Gln Glu Thr Phe Trp Val Ala Ser Glu Ile Leu Thr Glu Ala Asn
         960                 965                 970

 cag ctc aaa cga atg aag att att aag cat ttt att aaa att gca ctt     3036
 Gln Leu Lys Arg Met Lys Ile Ile Lys His Phe Ile Lys Ile Ala Leu
     975                 980                 985

 cat tgt cga gaa tgt aag aac ttc aat tcc atg ttt gca ata ata agt     3084
 His Cys Arg Glu Cys Lys Asn Phe Asn Ser Met Phe Ala Ile Ile Ser
 990                 995                1000                1005

 ggc ttg aac ctg gca tct gta gca aga ctc aga gga act tgg gaa aag     3132
 Gly Leu Asn Leu Ala Ser Val Ala Arg Leu Arg Gly Thr Trp Glu Lys
                1010                1015                1020

 tta cca agc aaa tac gag aaa cat ctt caa gat cta caa gac att ttt     3180
 Leu Pro Ser Lys Tyr Glu Lys His Leu Gln Asp Leu Gln Asp Ile Phe
            1025                1030                1035

 gat cca tct aga aac atg gca aag tat aga aat att ctt agt agt caa     3228
 Asp Pro Ser Arg Asn Met Ala Lys Tyr Arg Asn Ile Leu Ser Ser Gln
        1040                1045                1050

 agt atg cag cct cca att att cca ctc ttc cct gtt gtc aag aaa gat     3276
 Ser Met Gln Pro Pro Ile Ile Pro Leu Phe Pro Val Val Lys Lys Asp
    1055                1060                1065

 atg aca ttt cta cat gaa gga aat gac tcc aaa gta gat ggt tta gta     3324
 Met Thr Phe Leu His Glu Gly Asn Asp Ser Lys Val Asp Gly Leu Val
1070                1075                1080                1085

 aac ttt gag aag tta aga atg att tcc aag gaa atc cgc caa gtt gtt     3372
 Asn Phe Glu Lys Leu Arg Met Ile Ser Lys Glu Ile Arg Gln Val Val
                1090                1095                1100

 cga atg act tct gct aac atg gac cca gct atg atg ttt cga cag agg     3420
 Arg Met Thr Ser Ala Asn Met Asp Pro Ala Met Met Phe Arg Gln Arg
            1105                1110                1115

 tca ctg agt caa gga agc aca aat tca aac atg ctg gat gtt cag gga     3468
 Ser Leu Ser Gln Gly Ser Thr Asn Ser Asn Met Leu Asp Val Gln Gly
        1120                1125                1130

 ggt gct cac aaa aaa agg gca cgc cgc agc tct ctg ctt aat gcc aag     3516
 Gly Ala His Lys Lys Arg Ala Arg Arg Ser Ser Leu Leu Asn Ala Lys
    1135                1140                1145

 aag cta tat gag gat gcc caa atg gca agg aag gtg aag cag tat ctt     3564
 Lys Leu Tyr Glu Asp Ala Gln Met Ala Arg Lys Val Lys Gln Tyr Leu
1150                1155                1160                1165

 tcc agt ctc gat gta gag aca gat gag gag aag ttc cag atg atg tca     3612
 Ser Ser Leu Asp Val Glu Thr Asp Glu Glu Lys Phe Gln Met Met Ser
                1170                1175                1180

 tta cag tgg gag cct gca tat ggt acc ttg acc aag aat tta agt gag     3660
 Leu Gln Trp Glu Pro Ala Tyr Gly Thr Leu Thr Lys Asn Leu Ser Glu
            1185                1190                1195

 aaa aga tca gcc aag atc atc tga aatgtctcca gtgcctatga ggtcagctgg    3714
 Lys Arg Ser Ala Lys Ile Ile 
        1200

 ccaaacaact aaagcccact tgcatcaacc ccacagagta agccaggtgc ttcaggtgcc   3774

 agctgttaat ttgcacccca tcaggaagaa gggacaaaca aaagaccctg cactgaatac   3834

 aagtttacct cagaaagttt taggaacaac tgaagaaata agtggtaaga agcatacaga   3894

 agacactatt tctgtggcgt catctttaca ttctagtcct cctgcatctc ctcaaggctc   3954

 ccctcacaaa ggttacacac ttattccatc agctaaatct gacaacttgt ctgactccag   4014

 ccatagtgag atttcttcac ggtccagcat cgtgagcaat tgttctgttg actccatgtc   4074

 tgcagctcta caggatgaac ggtgttcctc tcaggccctg gcagtccctg aatccactgg   4134

 ggcattggaa aagacagagc acgcttcagg gataggagat catagtcaac atggccctgg   4194

 gtggacactc ttgaagccat ctctaatcaa gtgtttagct gtctcatcgt ctgtgagcaa   4254

 tgaagagatt tctcaagagc atatcattat agaagcagct gacagtggtc gtggaagttg   4314

 gacttcgtgt tcaagcagct cccatgacaa cttccaaagc cttccaaacc caaaaagctg   4374

 ggattttttg aactcttaca gacataccca tttggatgac cccattgctg aagttgaacc   4434

 cactgactct gagccctatt cctgttctaa aagctgctct agaacttgtg ggcagtgtaa   4494

 aggaagccta gagagaaaga gttggacctc ctccagttct ctgtctgaca cgtatgaacc   4554

 aaactatggg acagttaaac ggagagtatt ggagagcacc ccagctgagt catctgaagg   4614

 cttggacccc aaggatgcca ctgacccagt ttataaaact gtcacttcaa gtacagaaaa   4674

 gggcttgatt gtgtactgtg tcacctcacc caagaaggac gataggtata gggagccacc   4734

 tcccactcct ccaggatatt tggggatttc tttagcggac ctaaaggaag gaccccacac   4794

 acacctaaaa cctccagatt atagtgtggc agtgcagagg tcaaagatga tgcataacag   4854

 cctctctaga ctgccaccag cttctctcag tagcaacctc gtggcctgtg ttccatcgaa   4914

 gattgtaact cagcctcaga ggcataattt gcagccattc catcctaaac taggagatgt   4974

 gactgatgca gatagcgaag cagatgaaaa tgaacaagtt tcagcagtct agcctttgga   5034

 tgacctattt gaaaaccact gaaagtcgtg gaggaatggg caagaaccac ctcatgattc   5094

 tgcaggccat tgctaacgaa cagctcattg ctacaaccag tccagaggtt ttattccctc   5154

 tactccgagc aatgaaatag acctgagtta tgcttccttt catttaattt ctgcagataa   5214

 atagtttcct gagcaatgga tgctatgcct ggataccagt ctccactttg cacgccggaa   5274

 ctgccttggg accacagtta cagaaaaaat gtaaactcag agtgatcctt gtgtatattg   5334

 ctatagattt ttctttaaca agctatttta aagataatgg cattattatt tccaagccat   5394

 agcttgggct gaaggacaaa ttgaaattgt ctgccaatac caaggatatt cttgtatatt   5454

 tgaaaaataa cttattattt gaattgttgt ggttttgttt gtatttgaga gctcttgtta   5514

 gctgatattc atgtttgagg tcataaaatt gtctctggtc tgaccaaaca gaagtcatct   5574

 ttacagaggt gatatgcttg atctacacag agatgtgact tgatctgtag caccaatgca   5634

 atgtaggtct cagtttgaga gaaataggaa gccctttgca gttgaggtgt taggaacctg   5694

 ctggtcatgg tgtggaaggc caaatgaagc tgccacaggg tttcttgtca gtcctttggg   5754

 aaatgggagg gagtagtttg gggaggaggg tgggaaccct aatttccaca gaatgaaatt   5814

 ttgatgttaa atgacatgta tacaaattct tccttaagtg aaagttatgc tgcatcgaat   5874

 tgtaactgaa agtatagatc caacaaatag agactgggtt ctagagagtt ctggtctata   5934

 gaaacccaaa actaaaatct ctcataactc aagtatggaa tacttttttt aaagaaattc   5994

 ttatcatggg tgttgtaata atgaagacga atttgacttt atgcagtgtt ttgcagcatg   6054

 cctcccccac atctcatagc accaggttgt gtctgacctg acataccctg cagctctcag   6114

 ctggctgcag taacattttg tgggagaaag aggagctgga gttacagaaa tgattgtctc   6174

 ttggttctca gtttttagcc cttgagagga catacttttc cagcctcatg ggtatggcac   6234

 tcttaattaa aatttcagtg actgtttact ggatgaggca gatttttcac atttttgcaa   6294

 attaaatata ttttatatat attaagttta attttttcag tttttttaat gtaaaagcaa   6354

 gtgaaatttt aataaacttc tgtaattacc                                    6384




      <210> 338
      <211> 6375
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (211)..(3675)

      <400> 338
 gtaccgctcc ggaattcccg ggtcgacgat ttcgtgtggg tagaggcctt aggcgggcgt     60

 tgcgaagggt tgtttgctag agttcggacc ttgttacggc gcgaagttcc ctccttgggg    120

 cgggggaaag gtaccgcacc cgctacctag tgtgaatgaa ctgtggcgtg ggctgctaag    180

 ggcaggctgc ggagtacccg ggccgtggcc     atg aac tca ccc gtg gac cct     231
                                      Met Asn Ser Pro Val Asp Pro
                                        1               5

 ggc gct agg cag gcg ttg agg aag aag cca ccc gag cgg act ccc gag      279
 Gly Ala Arg Gln Ala Leu Arg Lys Lys Pro Pro Glu Arg Thr Pro Glu
          10                  15                  20

 gac tta aat act att tat tct tat ctt cat gga atg gaa ata tta tca      327
 Asp Leu Asn Thr Ile Tyr Ser Tyr Leu His Gly Met Glu Ile Leu Ser
      25                  30                  35

 aat ctc agg gaa cat cag ctt aga tta atg tct gca aga gca cgc tat      375
 Asn Leu Arg Glu His Gln Leu Arg Leu Met Ser Ala Arg Ala Arg Tyr
  40                  45                  50                  55

 gag aga tac agt ggc aat cag gtt ctc ttt tgt tca gaa acg att gcc      423
 Glu Arg Tyr Ser Gly Asn Gln Val Leu Phe Cys Ser Glu Thr Ile Ala
                  60                  65                  70

 aga tgt tgg tat atc cta ctt tct gga tct gtg ctt gtg aaa ggc tcc      471
 Arg Cys Trp Tyr Ile Leu Leu Ser Gly Ser Val Leu Val Lys Gly Ser
              75                  80                  85

 atg gtc ttg cct cct tgc agt ttt ggt aag cag ttt gga gga aaa aga      519
 Met Val Leu Pro Pro Cys Ser Phe Gly Lys Gln Phe Gly Gly Lys Arg
          90                  95                 100

 gga tgt gat tgt ctt gta tta gag cct tca gaa atg att gtg gta gag      567
 Gly Cys Asp Cys Leu Val Leu Glu Pro Ser Glu Met Ile Val Val Glu
     105                 110                 115

 aat gcc aaa gat aat gaa gat agt att cta caa aga gaa att cct gcc      615
 Asn Ala Lys Asp Asn Glu Asp Ser Ile Leu Gln Arg Glu Ile Pro Ala
 120                 125                 130                 135

 aga caa tcc cga aga aga ttt cgg aaa att aac tat aaa gga gag cgc      663
 Arg Gln Ser Arg Arg Arg Phe Arg Lys Ile Asn Tyr Lys Gly Glu Arg
                 140                 145                 150

 caa acc att act gat gat gtg gag gtt aac agc tat ctt tct ctt cca      711
 Gln Thr Ile Thr Asp Asp Val Glu Val Asn Ser Tyr Leu Ser Leu Pro
             155                 160                 165

 gct gat ctt acc aag atg cat ctc aca gaa aac cct cat cca cag gtg      759
 Ala Asp Leu Thr Lys Met His Leu Thr Glu Asn Pro His Pro Gln Val
         170                 175                 180

 act cat gtg tct tct agt cag tct ggt tgt agc att gcc agt gac tct      807
 Thr His Val Ser Ser Ser Gln Ser Gly Cys Ser Ile Ala Ser Asp Ser
     185                 190                 195

 gga agc agc agt tta tct gat atc tat cag gct acg gag agt gag gta      855
 Gly Ser Ser Ser Leu Ser Asp Ile Tyr Gln Ala Thr Glu Ser Glu Val
 200                 205                 210                 215

 gga gat gta gat ttg aca cgt ctt cca gaa gga cct gtt gat tct gag      903
 Gly Asp Val Asp Leu Thr Arg Leu Pro Glu Gly Pro Val Asp Ser Glu
                 220                 225                 230

 gat gac gaa gag gaa gat gaa gag att gat cga aca gat cca ttg cag      951
 Asp Asp Glu Glu Glu Asp Glu Glu Ile Asp Arg Thr Asp Pro Leu Gln
             235                 240                 245

 ggg cga gat ctt gtt cga gaa tgt ctt gaa aaa gaa cct gca gac aaa      999
 Gly Arg Asp Leu Val Arg Glu Cys Leu Glu Lys Glu Pro Ala Asp Lys
         250                 255                 260

 act gat gat gac att gaa caa ttg ctg gag ttt atg cac cag ctc cct     1047
 Thr Asp Asp Asp Ile Glu Gln Leu Leu Glu Phe Met His Gln Leu Pro
     265                 270                 275

 gca ttt gca aac atg acc atg tct gta agg aga gaa ctc tgc tca gtg     1095
 Ala Phe Ala Asn Met Thr Met Ser Val Arg Arg Glu Leu Cys Ser Val
 280                 285                 290                 295

 atg att ttt gaa gtg gta gag cag gct gga gct att att ctt gaa gat     1143
 Met Ile Phe Glu Val Val Glu Gln Ala Gly Ala Ile Ile Leu Glu Asp
                 300                 305                 310

 ggg caa gag ctt gac tca tgg tat gtt att tta aac ggc act gtg gaa     1191
 Gly Gln Glu Leu Asp Ser Trp Tyr Val Ile Leu Asn Gly Thr Val Glu
             315                 320                 325

 atc agt cat cca gat gga aaa gtt gaa aat ttg ttt atg gga aat agt     1239
 Ile Ser His Pro Asp Gly Lys Val Glu Asn Leu Phe Met Gly Asn Ser
         330                 335                 340

 ttt gga att act ccc act ctg gat aag cag tac atg cat gga att gtc     1287
 Phe Gly Ile Thr Pro Thr Leu Asp Lys Gln Tyr Met His Gly Ile Val
     345                 350                 355

 agg act aaa gta gat gat tgt cag ttt gtc tgc ata gcc cag caa gat     1335
 Arg Thr Lys Val Asp Asp Cys Gln Phe Val Cys Ile Ala Gln Gln Asp
 360                 365                 370                 375

 tat tgg aga att tta aac cat gtg gaa aaa aat acc cat aaa gtt gag     1383
 Tyr Trp Arg Ile Leu Asn His Val Glu Lys Asn Thr His Lys Val Glu
                 380                 385                 390

 gaa gag gga gaa att gtt atg gta cat gag cat cgg gaa cta gac cgg     1431
 Glu Glu Gly Glu Ile Val Met Val His Glu His Arg Glu Leu Asp Arg
             395                 400                 405

 agt gga acc agg aaa gga cac att gtg atc aag gca aca cct gag cgt     1479
 Ser Gly Thr Arg Lys Gly His Ile Val Ile Lys Ala Thr Pro Glu Arg
         410                 415                 420

 ctc ata atg cat tta ata gaa gaa cat tcc atc gtg gat cca act tat     1527
 Leu Ile Met His Leu Ile Glu Glu His Ser Ile Val Asp Pro Thr Tyr
     425                 430                 435

 ata gaa gat ttt cta tta act tac agg aca ttt ctt gaa agt cct ttg     1575
 Ile Glu Asp Phe Leu Leu Thr Tyr Arg Thr Phe Leu Glu Ser Pro Leu
 440                 445                 450                 455

 gat gtt ggg atc aaa cta ttg gaa tgg ttt aag atc gac agc tta aga     1623
 Asp Val Gly Ile Lys Leu Leu Glu Trp Phe Lys Ile Asp Ser Leu Arg
                 460                 465                 470

 gat aag gtg aca cgg att gta tta tta tgg gta aat aat cat ttt aat     1671
 Asp Lys Val Thr Arg Ile Val Leu Leu Trp Val Asn Asn His Phe Asn
             475                 480                 485

 gat ttt gaa ggt gac cct gct atg act cga ttt cta gag gaa ttt gaa     1719
 Asp Phe Glu Gly Asp Pro Ala Met Thr Arg Phe Leu Glu Glu Phe Glu
         490                 495                 500

 aaa aat ctg gaa gat aca aag atg aat ggt cat ctc cgg tta ttg aat     1767
 Lys Asn Leu Glu Asp Thr Lys Met Asn Gly His Leu Arg Leu Leu Asn
     505                 510                 515

 att gcc tgt gct gca aag gct aag tgg aga cag gtt gtg ctg caa aag     1815
 Ile Ala Cys Ala Ala Lys Ala Lys Trp Arg Gln Val Val Leu Gln Lys
 520                 525                 530                 535

 gct tcc cgc gag tcc cct cta caa ttc agc ctt aat gga ggg agt gag     1863
 Ala Ser Arg Glu Ser Pro Leu Gln Phe Ser Leu Asn Gly Gly Ser Glu
                 540                 545                 550

 aag gga ttt ggt att ttt gtt gaa gga gta gaa cct ggt agc aaa gct     1911
 Lys Gly Phe Gly Ile Phe Val Glu Gly Val Glu Pro Gly Ser Lys Ala
             555                 560                 565

 gct gat tca gga ctg aaa cgt ggt gat cag att atg gaa gta aat gga     1959
 Ala Asp Ser Gly Leu Lys Arg Gly Asp Gln Ile Met Glu Val Asn Gly
         570                 575                 580

 caa aac ttt gag aat att aca ttt atg aaa gcc gtt gaa att ttg agg     2007
 Gln Asn Phe Glu Asn Ile Thr Phe Met Lys Ala Val Glu Ile Leu Arg
     585                 590                 595

 aat aat act cat ctt gca ctt act gtg aag acc aac att ttt gtg ttc     2055
 Asn Asn Thr His Leu Ala Leu Thr Val Lys Thr Asn Ile Phe Val Phe
 600                 605                 610                 615

 aaa gag tta ctt ttt agg act gaa caa gag aaa tct ggt gtt cct cat     2103
 Lys Glu Leu Leu Phe Arg Thr Glu Gln Glu Lys Ser Gly Val Pro His
                 620                 625                 630

 att ccc aaa att gct gaa aaa aaa agt aat cgc cat tct atc cag cat     2151
 Ile Pro Lys Ile Ala Glu Lys Lys Ser Asn Arg His Ser Ile Gln His
             635                 640                 645

 gtg cca gga gat att gaa cag aca tca cag gag aaa gga agt aag aaa     2199
 Val Pro Gly Asp Ile Glu Gln Thr Ser Gln Glu Lys Gly Ser Lys Lys
         650                 655                 660

 gtt aaa gca aat act gtt tca ggt gga aga aac aaa atc agg aag att     2247
 Val Lys Ala Asn Thr Val Ser Gly Gly Arg Asn Lys Ile Arg Lys Ile
     665                 670                 675

 ttg gat aaa aca cga ttt agt atc ttg cct cca aag cta ttt agt gat     2295
 Leu Asp Lys Thr Arg Phe Ser Ile Leu Pro Pro Lys Leu Phe Ser Asp
 680                 685                 690                 695

 gga ggc cta agc caa tca caa gat gac agc att gtg gga aca agg cac     2343
 Gly Gly Leu Ser Gln Ser Gln Asp Asp Ser Ile Val Gly Thr Arg His
                 700                 705                 710

 tgt agg cat agt ctg gct ata atg ccc atc cct gga aca ctc tca tcc     2391
 Cys Arg His Ser Leu Ala Ile Met Pro Ile Pro Gly Thr Leu Ser Ser
             715                 720                 725

 agc agc cct gat ctc ctg cag cct acc acc agt atg ttg gat ttt tcc     2439
 Ser Ser Pro Asp Leu Leu Gln Pro Thr Thr Ser Met Leu Asp Phe Ser
         730                 735                 740

 aat cct tca gat atc cct gat caa gtt ata aga gtt ttc aaa gtg gat     2487
 Asn Pro Ser Asp Ile Pro Asp Gln Val Ile Arg Val Phe Lys Val Asp
     745                 750                 755

 cag caa agt tgc tac att atc atc agt aaa gac acc aca gct aaa gaa     2535
 Gln Gln Ser Cys Tyr Ile Ile Ile Ser Lys Asp Thr Thr Ala Lys Glu
 760                 765                 770                 775

 gta gtt ttt cat gct gtt cat gaa ttt ggt ttg acc ggt gca tcc gac     2583
 Val Val Phe His Ala Val His Glu Phe Gly Leu Thr Gly Ala Ser Asp
                 780                 785                 790

 aca tat tct ctc tgt gaa gtt tct gtt act cct gag ggt gtc ata aaa     2631
 Thr Tyr Ser Leu Cys Glu Val Ser Val Thr Pro Glu Gly Val Ile Lys
             795                 800                 805

 cag aga aga ctt cca gat cag ttc tcc aaa tta gct gat aga att caa     2679
 Gln Arg Arg Leu Pro Asp Gln Phe Ser Lys Leu Ala Asp Arg Ile Gln
         810                 815                 820

 ctc aat gga agg tat tac tta aaa aat aac atg gaa aca gaa acc tta     2727
 Leu Asn Gly Arg Tyr Tyr Leu Lys Asn Asn Met Glu Thr Glu Thr Leu
     825                 830                 835

 tgt tca gat gaa gat gct caa gaa cta gtt aag gaa agc cag cta tcc     2775
 Cys Ser Asp Glu Asp Ala Gln Glu Leu Val Lys Glu Ser Gln Leu Ser
 840                 845                 850                 855

 atg ctg cag ctc agt acc att gag gtg gcc acc cag ctg tca atg agg     2823
 Met Leu Gln Leu Ser Thr Ile Glu Val Ala Thr Gln Leu Ser Met Arg
                 860                 865                 870

 gac ttt gat ttg ttt cgt aat att gaa ccg act gag tac atc gat gac     2871
 Asp Phe Asp Leu Phe Arg Asn Ile Glu Pro Thr Glu Tyr Ile Asp Asp
             875                 880                 885

 ctt ttt aag tta aat tcc aaa aca gga aat act cat ttg aag agg ttt     2919
 Leu Phe Lys Leu Asn Ser Lys Thr Gly Asn Thr His Leu Lys Arg Phe
         890                 895                 900

 gag gac att gta aac caa gag aca ttc tgg gtt gcc tca gaa att tta     2967
 Glu Asp Ile Val Asn Gln Glu Thr Phe Trp Val Ala Ser Glu Ile Leu
     905                 910                 915

 act gaa gca aat cag ctc aaa cga atg aag att att aag cat ttt att     3015
 Thr Glu Ala Asn Gln Leu Lys Arg Met Lys Ile Ile Lys His Phe Ile
 920                 925                 930                 935

 aaa att gca ctt cat tgt cga gaa tgt aag aac ttc aat tcc atg ttt     3063
 Lys Ile Ala Leu His Cys Arg Glu Cys Lys Asn Phe Asn Ser Met Phe
                 940                 945                 950

 gca ata ata agt ggc ttg aac ctg gca tct gta gca aga ctc aga gga     3111
 Ala Ile Ile Ser Gly Leu Asn Leu Ala Ser Val Ala Arg Leu Arg Gly
             955                 960                 965

 act tgg gaa aag tta cca agc aaa tac gag aaa cat ctt caa gat cta     3159
 Thr Trp Glu Lys Leu Pro Ser Lys Tyr Glu Lys His Leu Gln Asp Leu
         970                 975                 980

 caa gac att ttt gat cca tct aga aac atg gca aag tat aga aat att     3207
 Gln Asp Ile Phe Asp Pro Ser Arg Asn Met Ala Lys Tyr Arg Asn Ile
     985                 990                 995

 ctt agt agt caa agt atg cag cct cca att att cca ctc ttc cct gtt     3255
 Leu Ser Ser Gln Ser Met Gln Pro Pro Ile Ile Pro Leu Phe Pro Val
1000                1005                1010                1015

 gtc aag aaa gat atg aca ttt cta cat gaa gga aat gac tcc aaa gta     3303
 Val Lys Lys Asp Met Thr Phe Leu His Glu Gly Asn Asp Ser Lys Val
                1020                1025                1030

 gat ggt tta gta aac ttt gag aag tta aga atg att tcc aag gaa atc     3351
 Asp Gly Leu Val Asn Phe Glu Lys Leu Arg Met Ile Ser Lys Glu Ile
            1035                1040                1045

 cgc caa gtt gtt cga atg act tct gct aac atg gac cca gct atg atg     3399
 Arg Gln Val Val Arg Met Thr Ser Ala Asn Met Asp Pro Ala Met Met
        1050                1055                1060

 ttt cga cag agg tca ctg agt caa gga agc aca aat tca aac atg ctg     3447
 Phe Arg Gln Arg Ser Leu Ser Gln Gly Ser Thr Asn Ser Asn Met Leu
    1065                1070                1075

 gat gtt cag gga ggt gct cac aaa aaa agg gca cgc cgc agc tct ctg     3495
 Asp Val Gln Gly Gly Ala His Lys Lys Arg Ala Arg Arg Ser Ser Leu
1080                1085                1090                1095

 ctt aat gcc aag aag cta tat gag gat gcc caa atg gca agg aag gtg     3543
 Leu Asn Ala Lys Lys Leu Tyr Glu Asp Ala Gln Met Ala Arg Lys Val
                1100                1105                1110

 aag cag tat ctt tcc agt ctc gat gta gag aca gat gag gag aag ttc     3591
 Lys Gln Tyr Leu Ser Ser Leu Asp Val Glu Thr Asp Glu Glu Lys Phe
            1115                1120                1125

 cag atg atg tca tta cag tgg gag cct gca tat ggt acc ttg acc aag     3639
 Gln Met Met Ser Leu Gln Trp Glu Pro Ala Tyr Gly Thr Leu Thr Lys
        1130                1135                1140

 aat tta agt gag aaa aga tca gcc aag atc atc tga aatg tctccagtgc     3689
 Asn Leu Ser Glu Lys Arg Ser Ala Lys Ile Ile 
    1145                1150

 ctatgaggtc agctggccaa acaactaaag cccacttgca tcaaccccac agagtaagcc   3749

 aggtgcttca ggtgccagct gttaatttgc accccatcag gaagaaggga caaacaaaag   3809

 accctgcact gaatacaagt ttacctcaga aagttttagg aacaactgaa gaaataagtg   3869

 gtaagaagca tacagaagac actatttctg tggcgtcatc tttacattct agtcctcctg   3929

 catctcctca aggctcccct cacaaaggtt acacacttat tccatcagct aaatctgaca   3989

 acttgtctga ctccagccat agtgagattt cttcacggtc cagcatcgtg agcaattgtt   4049

 ctgttgactc catgtctgca gctctacagg atgaacggtg ttcctctcag gccctggcag   4109

 tccctgaatc cactggggca ttggaaaaga cagagcacgc ttcagggata ggagatcata   4169

 gtcaacatgg ccctgggtgg acactcttga agccatctct aatcaagtgt ttagctgtct   4229

 catcgtctgt gagcaatgaa gagatttctc aagagcatat cattatagaa gcagctgaca   4289

 gtggtcgtgg aagttggact tcgtgttcaa gcagctccca tgacaacttc caaagccttc   4349

 caaacccaaa aagctgggat tttttgaact cttacagaca tacccatttg gatgacccca   4409

 ttgctgaagt tgaacccact gactctgagc cctattcctg ttctaaaagc tgctctagaa   4469

 cttgtgggca gtgtaaagga agcctagaga gaaagagttg gacctcctcc agttctctgt   4529

 ctgacacgta tgaaccaaac tatgggacag ttaaacggag agtattggag agcaccccag   4589

 ctgagtcatc tgaaggcttg gaccccaagg atgccactga cccagtttat aaaactgtca   4649

 cttcaagtac agaaaagggc ttgattgtgt actgtgtcac ctcacccaag aaggacgata   4709

 ggtataggga gccacctccc actcctccag gatatttggg gatttcttta gcggacctaa   4769

 aggaaggacc ccacacacac ctaaaacctc cagattatag tgtggcagtg cagaggtcaa   4829

 agatgatgca taacagcctc tctagactgc caccagcttc tctcagtagc aacctcgtgg   4889

 cctgtgttcc atcgaagatt gtaactcagc ctcagaggca taatttgcag ccattccatc   4949

 ctaaactagg agatgtgact gatgcagata gcgaagcaga tgaaaatgaa caagtttcag   5009

 cagtctagcc tttggatgac ctatttgaaa accactgaaa gtcgtggagg aatgggcaag   5069

 aaccacctca tgattctgca ggccattgct aacgaacagc tcattgctac aaccagtcca   5129

 gaggttttat tccctctact ccgagcaatg aaatagacct gagttatgct tcctttcatt   5189

 taatttctgc agataaatag tttcctgagc aatggatgct atgcctggat accagtctcc   5249

 actttgcacg ccggaactgc cttgggacca cagttacaga aaaaatgtaa actcagagtg   5309

 atccttgtgt atattgctat agatttttct ttaacaagct attttaaaga taatggcatt   5369

 attatttcca agccatagct tgggctgaag gacaaattga aattgtctgc caataccaag   5429

 gatattcttg tatatttgaa aaataactta ttatttgaat tgttgtggtt ttgtttgtat   5489

 ttgagagctc ttgttagctg atattcatgt ttgaggtcat aaaattgtct ctggtctgac   5549

 caaacagaag tcatctttac agaggtgata tgcttgatct acacagagat gtgacttgat   5609

 ctgtagcacc aatgcaatgt aggtctcagt ttgagagaaa taggaagccc tttgcagttg   5669

 aggtgttagg aacctgctgg tcatggtgtg gaaggccaaa tgaagctgcc acagggtttc   5729

 ttgtcagtcc tttgggaaat gggagggagt agtttgggga ggagggtggg aaccctaatt   5789

 tccacagaat gaaattttga tgttaaatga catgtataca aattcttcct taagtgaaag   5849

 ttatgctgca tcgaattgta actgaaagta tagatccaac aaatagagac tgggttctag   5909

 agagttctgg tctatagaaa cccaaaacta aaatctctca taactcaagt atggaatact   5969

 ttttttaaag aaattcttat catgggtgtt gtaataatga agacgaattt gactttatgc   6029

 agtgttttgc agcatgcctc ccccacatct catagcacca ggttgtgtct gacctgacat   6089

 accctgcagc tctcagctgg ctgcagtaac attttgtggg agaaagagga gctggagtta   6149

 cagaaatgat tgtctcttgg ttctcagttt ttagcccttg agaggacata cttttccagc   6209

 ctcatgggta tggcactctt aattaaaatt tcagtgactg tttactggat gaggcagatt   6269

 tttcacattt ttgcaaatta aatatatttt atatatatta agtttaattt tttcagtttt   6329

 tttaatgtaa aagcaagtga aattttaata aacttctgta attacc                  6375




      <210> 339
      <211> 877
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(823)

      <400> 339
 agctgggtcc tgcttcctcc tggtcttgtc g   atg agg att ttt aga ccg tgg      52
                                      Met Arg Ile Phe Arg Pro Trp
                                        1               5

 aga ctg cgc tgc cct gcc ctg cac cta ccc tca ctc tcc gtg ttc tca      100
 Arg Leu Arg Cys Pro Ala Leu His Leu Pro Ser Leu Ser Val Phe Ser
          10                  15                  20

 cta agg tgg aaa ttg cct tcc ctc act act gac gag acc atg tgt aaa      148
 Leu Arg Trp Lys Leu Pro Ser Leu Thr Thr Asp Glu Thr Met Cys Lys
      25                  30                  35

 agc gtg acc aca gat gag tgg aag aaa gtc ttc tat gag aag atg gag      196
 Ser Val Thr Thr Asp Glu Trp Lys Lys Val Phe Tyr Glu Lys Met Glu
  40                  45                  50                  55

 gag gca aag ccg gct gac agc tgg gac ctc atc ata gac ccc aac ctc      244
 Glu Ala Lys Pro Ala Asp Ser Trp Asp Leu Ile Ile Asp Pro Asn Leu
                  60                  65                  70

 aag cac aat gtg ctg agc cct ggt tgg aag cag tac ctg gaa ttg cat      292
 Lys His Asn Val Leu Ser Pro Gly Trp Lys Gln Tyr Leu Glu Leu His
              75                  80                  85

 gct tca ggc agg ttc cac tgc tcc tgg tgc tgg cac acc tgg cag tcg      340
 Ala Ser Gly Arg Phe His Cys Ser Trp Cys Trp His Thr Trp Gln Ser
          90                  95                 100

 ccc tac gtg gtc atc ctc ttc cac atg ttc ctg gac cgc gcc cag cgg      388
 Pro Tyr Val Val Ile Leu Phe His Met Phe Leu Asp Arg Ala Gln Arg
     105                 110                 115

 gcg ggc tcg gtg cgc atg cgc gtc ttc aag cag ctg tgc tat gag tgc      436
 Ala Gly Ser Val Arg Met Arg Val Phe Lys Gln Leu Cys Tyr Glu Cys
 120                 125                 130                 135

 ggc acg gcg cgg ctg gac gag tcc agc atg ctg gag gag aac atc gag      484
 Gly Thr Ala Arg Leu Asp Glu Ser Ser Met Leu Glu Glu Asn Ile Glu
                 140                 145                 150

 ggc ctg gtg gac aac ctc atc acc agc ctg cgc gag cag tgc tac ggc      532
 Gly Leu Val Asp Asn Leu Ile Thr Ser Leu Arg Glu Gln Cys Tyr Gly
             155                 160                 165

 gag cgt ggc ggc cag tac cgc atc cac gtg gcc agc cgc cag gac aac      580
 Glu Arg Gly Gly Gln Tyr Arg Ile His Val Ala Ser Arg Gln Asp Asn
         170                 175                 180

 cgg cgg cac cgc gga gag ttc tgc gag gcc tgc cag gag ggc atc gtg      628
 Arg Arg His Arg Gly Glu Phe Cys Glu Ala Cys Gln Glu Gly Ile Val
     185                 190                 195

 cac tgg aag ccc agc gag aag ctg ctg gag gag gag gcg acc acc tac      676
 His Trp Lys Pro Ser Glu Lys Leu Leu Glu Glu Glu Ala Thr Thr Tyr
 200                 205                 210                 215

 acc ttc tcc cgg gcg ccc agc ccc acc aag tcg cag gac cag acg ggc      724
 Thr Phe Ser Arg Ala Pro Ser Pro Thr Lys Ser Gln Asp Gln Thr Gly
                 220                 225                 230

 tca ggc tgg aac ttc tgc tct atc ccc tgg tgc ttg ttt tgg gcc acg      772
 Ser Gly Trp Asn Phe Cys Ser Ile Pro Trp Cys Leu Phe Trp Ala Thr
             235                 240                 245

 gtc ctg ctg ctg atc atc tac ctg cag ttc tct ttc cgt agc tcc gta      820
 Val Leu Leu Leu Ile Ile Tyr Leu Gln Phe Ser Phe Arg Ser Ser Val
         250                 255                 260

 taa gatt ccgtggttgg gcccagagcc tgtcgagggt gccagttagc tgatgcgagg      877
 






      <210> 340
      <211> 1853
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(1824)

      <400> 340
 cccaccttca ggccatgcag ccatgttccg ggagccctaa ttgcacagaa gccc  atg      57
                                                              Met
                                                                1

 ggg agc tcc aga ctg gca gcc ctg ctc ctg cct ctc ctc ctc ata gtc      105
 Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile Val
               5                  10                  15

 atc gac ctc tct gac tct gct ggg att ggc ttt cgc cac ctg ccc cac      153
 Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro His
          20                  25                  30

 tgg aac acc cgc tgt cct ctg gcc tcc cac acg agg aag ctg ctg cct      201
 Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Arg Lys Leu Leu Pro
      35                  40                  45

 cgt cgt cac ctg tct gag aag agc cat cac att tcc atc ccc tcc cca      249
 Arg Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro
  50                  55                  60                  65

 gac atc tcc cac aag gga ctt cgc tct aaa agg acc caa cct tcg gat      297
 Asp Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp
                  70                  75                  80

 cca gag aca tgg gaa agt ctt ccc aga ttg gac tca caa agg cat gga      345
 Pro Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly
              85                  90                  95

 gga ccc gag ttc tcc ttt gat ttg ctg cct gag gcc cgg gct att cgg      393
 Gly Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg
         100                 105                 110

 gtg acc ata tct tca ggc cct gag gtc agc gtg cgt ctt tgt cac cag      441
 Val Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln
     115                 120                 125

 tgg gca ctg gag tgt gaa gag ctg agc agt ccc tat gat gtc cag aaa      489
 Trp Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys
 130                 135                 140                 145

 att gtg tct ggg ggc cac act gta gag ctg cct tat gaa ttc ctt ctg      537
 Ile Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu
                 150                 155                 160

 ccc tgt ctg tgc ata gag gca tcc tac ctg caa gag gac act gtg agg      585
 Pro Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg
             165                 170                 175

 cgc aaa aaa tgt ccc ttc cag agc tgg cca gaa gcc tat ggc tcg gac      633
 Arg Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp
         180                 185                 190

 ttc tgg aag tca gtg cac ttc act gac tac agc cag cac act cag atg      681
 Phe Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met
     195                 200                 205

 gtc atg gcc ctg aca ctc cgc tgc cca ctg aag ctg gaa gct gcc ctc      729
 Val Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu
 210                 215                 220                 225

 tgc cag agg cac gac tgg cat acc ctt tgc aaa gac ctc ccg aat gcc      777
 Cys Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala
                 230                 235                 240

 acg gct cga gag tca gat ggg tgg tat gtt ttg gag aag gtg gac ctg      825
 Thr Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu
             245                 250                 255

 cac ccc cag ctc tgc ttc aag ttc tct ttt gga aac agc agc cat gtt      873
 His Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val
         260                 265                 270

 gaa tgc ccc cac cag act ggg tct ctc aca tcc tgg aat gta agc atg      921
 Glu Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met
     275                 280                 285

 gat acc caa gcc cag cag ctg att ctt cac ttc tcc tca aga atg cat      969
 Asp Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met His
 290                 295                 300                 305

 gcc acc ttc agt gct gcc tgg agc ctc cca ggc ttg ggg cag gac act     1017
 Ala Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr
                 310                 315                 320

 ttg gtg ccc ccc gtg tac act gtc agc cag gcc cgg ggc tca agc cca     1065
 Leu Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro
             325                 330                 335

 gtg tca cta gac ctc atc att ccc ttc ctg agg cca ggg tgc tgt gtc     1113
 Val Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val
         340                 345                 350

 ctg gtg tgg cgg tca gat gtc cag ttt gcc tgg aag cac ctc ttg tgt     1161
 Leu Val Trp Arg Ser Asp Val Gln Phe Ala Trp Lys His Leu Leu Cys
     355                 360                 365

 cca gat gtc tct tac aga cac ctg ggg ctc ttg atc ctg gca ctg ctg     1209
 Pro Asp Val Ser Tyr Arg His Leu Gly Leu Leu Ile Leu Ala Leu Leu
 370                 375                 380                 385

 gcc ctc ctc acc cta ctg ggt gtt gtt ctg gcc ctc acc tgc cgg cgc     1257
 Ala Leu Leu Thr Leu Leu Gly Val Val Leu Ala Leu Thr Cys Arg Arg
                 390                 395                 400

 cca cag tca ggc ccg ggc cca gcg cgg cca gtg ctc ctc ctg cac gcg     1305
 Pro Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu Leu Leu His Ala
             405                 410                 415

 gcg gac tcg gag gcg cag cgg cgc ctg gtg gga gcg ctg gct gaa ctg     1353
 Ala Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala Leu Ala Glu Leu
         420                 425                 430

 cta cgg gca gcg ctg ggc ggc ggg cgc gac gtg atc gtg gac ctg tgg     1401
 Leu Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile Val Asp Leu Trp
     435                 440                 445

 gag ggg agg cac gtg gcg cgc gtg ggc ccg ctg ccg tgg ctc tgg gcg     1449
 Glu Gly Arg His Val Ala Arg Val Gly Pro Leu Pro Trp Leu Trp Ala
 450                 455                 460                 465

 gcg cgg acg cgc gta gcg cgg gag cag ggc act gtg ctg ctg ctg tgg     1497
 Ala Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val Leu Leu Leu Trp
                 470                 475                 480

 agc ggc gcc gac ctt cgc ccg gtc agc ggc ccc gac ccc cgc gcc gcg     1545
 Ser Gly Ala Asp Leu Arg Pro Val Ser Gly Pro Asp Pro Arg Ala Ala
             485                 490                 495

 ccc ctg ctc gcc ctg ctc cac gct gcc ccg cgc ccg ctg ctg ctg ctc     1593
 Pro Leu Leu Ala Leu Leu His Ala Ala Pro Arg Pro Leu Leu Leu Leu
         500                 505                 510

 gct tac ttc agt cgc ctc tgc gcc aag ggc gac atc ccc ccg ccg ctg     1641
 Ala Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro Leu
     515                 520                 525

 cgc gcc ctg ccg cgc tac cgc ctg ctg cgc gac ctg ccg cgt ctg ctg     1689
 Arg Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu Leu
 530                 535                 540                 545

 cgg gcg ctg gac gcg cgg cct ttc gca gag gcc acc agc tgg ggc cgc     1737
 Arg Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly Arg
                 550                 555                 560

 ctt ggg gcg cgg cag cgc agg cag agc cgc cta gag ctg tgc agc cgg     1785
 Leu Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser Arg
             565                 570                 575

 ctt gaa cga gag gcc gcc cga ctt gca gac cta ggt tga gcagagctcc      1834
 Leu Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly 
         580                 585

 accgcagtcc cgggtgtct                                                1853




      <210> 341
      <211> 2142
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (458)..(2113)

      <400> 341
 ggggccaggg caggctgggg cgagggctcc tgctggtact gtgttcgctg ctgcacagca     60

 aggccctgcc acccaccttc aggccatgca gccatgttcc gggagcccta attgcacaga    120

 agcccatggg gagctccaga ctggcagccc tgctcctgcc tctcctcctc atagtcatcg    180

 acctctctga ctctgctggg attggctttc gccacctgcc ccactggaac acccgctgtc    240

 ctctggcctc ccacacggaa gttctgccta tatcccttgc cgcacctggt gggccctctt    300

 ctccacaaag ccttggtgtg tgcgagtctg gcactgttcc cgctgtttgt gccagcatct    360

 gctgtcaggt ggctcaggtc ttcaacgggg cctcttccac ctcctggtgc agaaatccaa    420

 aaagtcttcc acattcaagt tctataggag acacaag atg cca gca cct gct cag     475
                                          Met Pro Ala Pro Ala Gln
                                            1               5

 agg aag ctg ctg cct cgt cgt cac ctg tct gag aag agc cat cac att      523
 Arg Lys Leu Leu Pro Arg Arg His Leu Ser Glu Lys Ser His His Ile
              10                  15                  20

 tcc atc ccc tcc cca gac atc tcc cac aag gga ctt cgc tct aaa agg      571
 Ser Ile Pro Ser Pro Asp Ile Ser His Lys Gly Leu Arg Ser Lys Arg
          25                  30                  35

 acc caa cct tcg gat cca gag aca tgg gaa agt ctt ccc aga ttg gac      619
 Thr Gln Pro Ser Asp Pro Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp
      40                  45                  50

 tca caa agg cat gga gga ccc gag ttc tcc ttt gat ttg ctg cct gag      667
 Ser Gln Arg His Gly Gly Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu
  55                  60                  65                  70

 gcc cgg gct att cgg gtg acc ata tct tca ggc cct gag gtc agc gtg      715
 Ala Arg Ala Ile Arg Val Thr Ile Ser Ser Gly Pro Glu Val Ser Val
                  75                  80                  85

 cgt ctt tgt cac cag tgg gca ctg gag tgt gaa gag ctg agc agt ccc      763
 Arg Leu Cys His Gln Trp Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro
              90                  95                 100

 tat gat gtc cag aaa att gtg tct ggg ggc cac act gta gag ctg cct      811
 Tyr Asp Val Gln Lys Ile Val Ser Gly Gly His Thr Val Glu Leu Pro
         105                 110                 115

 tat gaa ttc ctt ctg ccc tgt ctg tgc ata gag gca tcc tac ctg caa      859
 Tyr Glu Phe Leu Leu Pro Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln
     120                 125                 130

 gag gac act gtg agg cgc aaa aaa tgt ccc ttc cag agc tgg cca gaa      907
 Glu Asp Thr Val Arg Arg Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu
 135                 140                 145                 150

 gcc tat ggc tcg gac ttc tgg aag tca gtg cac ttc act gac tac agc      955
 Ala Tyr Gly Ser Asp Phe Trp Lys Ser Val His Phe Thr Asp Tyr Ser
                 155                 160                 165

 cag cac act cag atg gtc atg gcc ctg aca ctc cgc tgc cca ctg aag     1003
 Gln His Thr Gln Met Val Met Ala Leu Thr Leu Arg Cys Pro Leu Lys
             170                 175                 180

 ctg gaa gct gcc ctc tgc cag agg cac gac tgg cat acc ctt tgc aaa     1051
 Leu Glu Ala Ala Leu Cys Gln Arg His Asp Trp His Thr Leu Cys Lys
         185                 190                 195

 gac ctc ccg aat gcc acg gct cga gag tca gat ggg tgg tat gtt ttg     1099
 Asp Leu Pro Asn Ala Thr Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu
     200                 205                 210

 gag aag gtg gac ctg cac ccc cag ctc tgc ttc aag ttc tct ttt gga     1147
 Glu Lys Val Asp Leu His Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly
 215                 220                 225                 230

 aac agc agc cat gtt gaa tgc ccc cac cag act ggg tct ctc aca tcc     1195
 Asn Ser Ser His Val Glu Cys Pro His Gln Thr Gly Ser Leu Thr Ser
                 235                 240                 245

 tgg aat gta agc atg gat acc caa gcc cag cag ctg att ctt cac ttc     1243
 Trp Asn Val Ser Met Asp Thr Gln Ala Gln Gln Leu Ile Leu His Phe
             250                 255                 260

 tcc tca aga atg cat gcc acc ttc agt gct gcc tgg agc ctc cca ggc     1291
 Ser Ser Arg Met His Ala Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly
         265                 270                 275

 ttg ggg cag gac act ttg gtg ccc ccc gtg tac act gtc agc cag gcc     1339
 Leu Gly Gln Asp Thr Leu Val Pro Pro Val Tyr Thr Val Ser Gln Ala
     280                 285                 290

 cgg ggc tca agc cca gtg tca cta gac ctc atc att ccc ttc ctg agg     1387
 Arg Gly Ser Ser Pro Val Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg
 295                 300                 305                 310

 cca ggg tgc tgt gtc ctg gtg tgg cgg tca gat gtc cag ttt gcc tgg     1435
 Pro Gly Cys Cys Val Leu Val Trp Arg Ser Asp Val Gln Phe Ala Trp
                 315                 320                 325

 aag cac ctc ttg tgt cca gat gtc tct tac aga cac ctg ggg ctc ttg     1483
 Lys His Leu Leu Cys Pro Asp Val Ser Tyr Arg His Leu Gly Leu Leu
             330                 335                 340

 atc ctg gca ctg ctg gcc ctc ctc acc cta ctg ggt gtt gtt ctg gcc     1531
 Ile Leu Ala Leu Leu Ala Leu Leu Thr Leu Leu Gly Val Val Leu Ala
         345                 350                 355

 ctc acc tgc cgg cgc cca cag tca ggc ccg ggc cca gcg cgg cca gtg     1579
 Leu Thr Cys Arg Arg Pro Gln Ser Gly Pro Gly Pro Ala Arg Pro Val
     360                 365                 370

 ctc ctc ctg cac gcg gcg gac tcg gag gcg cag cgg cgc ctg gtg gga     1627
 Leu Leu Leu His Ala Ala Asp Ser Glu Ala Gln Arg Arg Leu Val Gly
 375                 380                 385                 390

 gcg ctg gct gaa ctg cta cgg gca gcg ctg ggc ggc ggg cgc gac gtg     1675
 Ala Leu Ala Glu Leu Leu Arg Ala Ala Leu Gly Gly Gly Arg Asp Val
                 395                 400                 405

 atc gtg gac ctg tgg gag ggg agg cac gtg gcg cgc gtg ggc ccg ctg     1723
 Ile Val Asp Leu Trp Glu Gly Arg His Val Ala Arg Val Gly Pro Leu
             410                 415                 420

 ccg tgg ctc tgg gcg gcg cgg acg cgc gta gcg cgg gag cag ggc act     1771
 Pro Trp Leu Trp Ala Ala Arg Thr Arg Val Ala Arg Glu Gln Gly Thr
         425                 430                 435

 gtg ctg ctg ctg tgg agc ggc gcc gac ctt cgc ccg gtc agc ggc ccc     1819
 Val Leu Leu Leu Trp Ser Gly Ala Asp Leu Arg Pro Val Ser Gly Pro
     440                 445                 450

 gac ccc cgc gcc gcg ccc ctg ctc gcc ctg ctc cac gct gcc ccg cgc     1867
 Asp Pro Arg Ala Ala Pro Leu Leu Ala Leu Leu His Ala Ala Pro Arg
 455                 460                 465                 470

 ccg ctg ctg ctg ctc gct tac ttc agt cgc ctc tgc gcc aag ggc gac     1915
 Pro Leu Leu Leu Leu Ala Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp
                 475                 480                 485

 atc ccc ccg ccg ctg cgc gcc ctg ccg cgc tac cgc ctg ctg cgc gac     1963
 Ile Pro Pro Pro Leu Arg Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp
             490                 495                 500

 ctg ccg cgt ctg ctg cgg gcg ctg gac gcg cgg cct ttc gca gag gcc     2011
 Leu Pro Arg Leu Leu Arg Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala
         505                 510                 515

 acc agc tgg ggc cgc ctt ggg gcg cgg cag cgc agg cag agc cgc cta     2059
 Thr Ser Trp Gly Arg Leu Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu
     520                 525                 530

 gag ctg tgc agc cgg ctt gaa cga gag gcc gcc cga ctt gca gac cta     2107
 Glu Leu Cys Ser Arg Leu Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu
 535                 540                 545                 550

 ggt tga gcagagctcc accgcagtcc cgggtgtct                             2142
 Gly 






      <210> 342
      <211> 3473
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (584)..(1414)

      <400> 342
 tagatagaga ggcgtaattc agccacactc agagaaggca gggcagggag gctgacggaa     60

 ctgctcaggg agacccagcg agaggctcat agatccagga ggaaaataaa tatgtgacag    120

 taaatctacg gaacctgtgt gccaccttga ctacttatgc tgtggctgat gtcactttgt    180

 gatcaccatg gtctttccca ctgatccccc gatgccaccc tagaattctc aacacagcac    240

 tccatagtgg attagagctc agattctgaa gtcagctaaa acagggttta aattttggct    300

 ccaccactta ctctgtgacc tgagtcacat ttcttagctt ctctgagcct ccatttcagc    360

 atctgtaaaa tgttactacc tactttatag gttttctgat gaggcttaag tgtggttgtg    420

 catgtgacca tcttagcata gtgtgtggca atggtaagca ctcagtgctg tcagctgttt    480

 ttaccgctgt tattatatta ctgtgttttc ccatgtcatt aggtctgtga tccaggcttc    540

 agcagacaat ccaggctgat gcttttgctg agtgcgctaa ggg  atg ctg gcc tgg     595
                                                  Met Leu Ala Trp
                                                    1

 cgg gat ggt gaa ctg gaa gca gaa acg tca tcc tct ctc ttc ctt ctt      643
 Arg Asp Gly Glu Leu Glu Ala Glu Thr Ser Ser Ser Leu Phe Leu Leu
   5                  10                  15                  20

 gcc atg cag gtg tgg atg tgt ggg ggc cgc atg gag gac atc ccc tgc      691
 Ala Met Gln Val Trp Met Cys Gly Gly Arg Met Glu Asp Ile Pro Cys
                  25                  30                  35

 tcc agg gtg ggc cat atc tac agg aag tat gtg ccc tac aag gtc ccg      739
 Ser Arg Val Gly His Ile Tyr Arg Lys Tyr Val Pro Tyr Lys Val Pro
              40                  45                  50

 gcc gga gtc agc ctg gcc cgg gta aga acc ctt aag cgg gtg gcc gaa      787
 Ala Gly Val Ser Leu Ala Arg Val Arg Thr Leu Lys Arg Val Ala Glu
          55                  60                  65

 gtg tgg atg gat gag tac gca gag tac att tac cag cgc cgg cct gaa      835
 Val Trp Met Asp Glu Tyr Ala Glu Tyr Ile Tyr Gln Arg Arg Pro Glu
      70                  75                  80

 tac cgc cac ctc tcc gct ggg gat gtc gca gtc cag aaa aag ctc cgc      883
 Tyr Arg His Leu Ser Ala Gly Asp Val Ala Val Gln Lys Lys Leu Arg
  85                  90                  95                 100

 agc tcc ctt aac tgc aag agt ttc aag tgg ttt atg acg aag ata gcc      931
 Ser Ser Leu Asn Cys Lys Ser Phe Lys Trp Phe Met Thr Lys Ile Ala
                 105                 110                 115

 tgg gac ctg ccc aaa ttc tac cca ccc gtg gag ccc ccg gct gca gct      979
 Trp Asp Leu Pro Lys Phe Tyr Pro Pro Val Glu Pro Pro Ala Ala Ala
             120                 125                 130

 tgg ggg gag atc cga aat gtg ggc aca ggg ctg tgt gca gac aca aag     1027
 Trp Gly Glu Ile Arg Asn Val Gly Thr Gly Leu Cys Ala Asp Thr Lys
         135                 140                 145

 cac ggg gcc ttg ggc tcc cca cta agg cta gag ggc tgc gtc cga ggc     1075
 His Gly Ala Leu Gly Ser Pro Leu Arg Leu Glu Gly Cys Val Arg Gly
     150                 155                 160

 cgt ggg gag gct gcc tgg aac aac atg cag gta ttc acc ttc acc tgg     1123
 Arg Gly Glu Ala Ala Trp Asn Asn Met Gln Val Phe Thr Phe Thr Trp
 165                 170                 175                 180

 aga gag gac atc cgg cct gga gac ccc cag cac acc aag aag ttc tgc     1171
 Arg Glu Asp Ile Arg Pro Gly Asp Pro Gln His Thr Lys Lys Phe Cys
                 185                 190                 195

 ttt gat gcc att tcc cac acc agc cct gtc acg ctg tac gac tgc cac     1219
 Phe Asp Ala Ile Ser His Thr Ser Pro Val Thr Leu Tyr Asp Cys His
             200                 205                 210

 agc atg aag ggc aac cag ctg tgg aaa tac cgc aaa gac aag acc ctg     1267
 Ser Met Lys Gly Asn Gln Leu Trp Lys Tyr Arg Lys Asp Lys Thr Leu
         215                 220                 225

 tac cac cct gtc agt ggc agc tgc atg gac tgc agt gaa agt gac cat     1315
 Tyr His Pro Val Ser Gly Ser Cys Met Asp Cys Ser Glu Ser Asp His
     230                 235                 240

 agg atc ttc atg aac acc tgc aac cca tcc tct ctc acc cag cag tgg     1363
 Arg Ile Phe Met Asn Thr Cys Asn Pro Ser Ser Leu Thr Gln Gln Trp
 245                 250                 255                 260

 ctg ttt gaa cac acc aac tca aca gtc ttg gaa aaa ttc aat agg aac     1411
 Leu Phe Glu His Thr Asn Ser Thr Val Leu Glu Lys Phe Asn Arg Asn
                 265                 270                 275

 tga gccc tcatgtcccc ttggcaggcc ccccagggtc tggcactcac tgcagacttc     1468
 


 ctctttcaag ggaggcaggg cccctgtggg cactaggtgt aaaaggtgct ggccaaatgg   1528

 ttcagggtga agagggctct tgattcaggg gctggggtct gcctggtcct tgagcccctg   1588

 agttgtgggg gtagggtgaa gagcatatcc cacaagaggc cccacaggga gcagagactg   1648

 ctttaatccc tgctgacatc acggaaaagc aacagagcct tttcaacttt gtcactatgt   1708

 ccccttgaac attatgtggg agaacaccaa ggtagcctag gccacccaaa agtgagtcct   1768

 gcgaggttgc ccagccctca gatggctctc ctacatgatg gtgctttaga aacaaaggta   1828

 aaatttgcct gtttggggca gcttttagta tcgatgccac tcatctgcag cagaagagaa   1888

 agaagtcctc ttggggcttt ttagtttctg ccgtcctggg gggaacattg cagttactgc   1948

 acagcttctg ttctctgtca caaccccagg tgatttggtc cggtcaaagg ccatacttgg   2008

 ggccctaaga gtgttcagta ttgaatgctg atcagctgcc aggtgaggag tcagaagagg   2068

 gagcccccct agacatttct ttgcagctat ggacatgcgg gatatctccc cctgctctct   2128

 gggtatttga aatgtcaatt ttagcactct ccaggcacaa ggacagccca gcaccagctt   2188

 tacagggcag tgtttcagat ggccctgagc ccacggaaaa ggccaggtag acctccaaac   2248

 tagaaatgct ggctgatttg ccctgatcca tgcttccatt tccctgtctc tcttccccag   2308

 gcaattactg gcctcaaaag aggaacagag gtgctgcgag gtgctcacct cacagagtct   2368

 ggaggcctcc aggatcaact gtgggcaaag tgcctgcctc tgacctcatc atggttctag   2428

 ttctcataca gaactccaga atttttaaag aactctataa ttggattgca aactaggatg   2488

 ctacatagga ttctggtatt ccacatccaa tatggatttc tagaatgctg tgattaaagg   2548

 agccagccag gtgtaataca gtcaaggcag cccccagcct agagacaatc tgtgaaatcc   2608

 aaagttggtg gtgttgggaa agcaggggga catgtgtccc tcagctcagc agaggctgtg   2668

 gtacaacatg gtccttggtg aagacctgca cccctggaac ctcccaccat catcacaact   2728

 gtagtctcat ttgcagtgga gaaaagaacc cgacgtccca cagccagata tacacccagc   2788

 tccatgccag cccttcatgt ttaccttttg ctttgttaat tacatgtcag actcctagag   2848

 ggcctccaga ctaataggaa gcatttctgt aaccaacctg ccacccactg attcagaaat   2908

 ggaaatcaca ttccacaatc tatggcttcc accagctagc ccaggaaata cttgaaatca   2968

 gcattccaat tagtgttgag tctcttgatt gtgtcattta ccaattaaat aactgagacc   3028

 taagtctggg aacagagcca cgaatctgcc tttgagatgc tggcagatct caaggccatc   3088

 aattattggg ggagggaggg acaaacactc ccaatcatcc accagtcaga ctgaatgtgt   3148

 agctggcgag gaattacttc cacttctggc ccagcacaag ccctgctttg gccacctgtc   3208

 tgcaagagag gcggcccctg tgcttgcaac gcttacgtgt tgatcccagt gtccttttcc   3268

 aaatgagtgc tgtagcttta gaagtggccc tctatagaaa gaagtcaaaa gatgaggccc   3328

 cttctagaat ctaggataac aagagtgttg acagtttgag gagtcgaatt gagattcatc   3388

 atcaaagagc aatgcagcgt cgttaaaata aaaactgtgc cttttaaaaa gaaaaatgca   3448

 aatatagagc aaatccctaa acttg                                         3473




      <210> 343
      <211> 780
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (133)..(780)

      <400> 343
 ggcgctgcgc tcgggctacc caatgcgtgg actatctgcc gccgctgttc gtgcaatatg     60

 ctggagctcc agaacagcta aacggagtcg ccacaccact gtttgtgctg gatcgcagcg    120

 ctgcctttcc tt    atg aag aag aca caa act tgg att ctc act tgc att     168
                  Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile
                    1               5                  10

 tat ctt cag ctg ctc cta ttt aat cct ctc gtc aaa act gaa ggg atc      216
 Tyr Leu Gln Leu Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile
          15                  20                  25

 tgc agg aat cgt gtg act aat aat gta aaa gac gtc act aaa ttg gtg      264
 Cys Arg Asn Arg Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val
      30                  35                  40

 gca aat ctt cca aaa gac tac atg ata acc ctc aaa tat gtc ccc ggg      312
 Ala Asn Leu Pro Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly
  45                  50                  55                  60

 atg gat gtt ttg ctg ttt tgt ctc ttt ttt cat atc ttg cag cca agt      360
 Met Asp Val Leu Leu Phe Cys Leu Phe Phe His Ile Leu Gln Pro Ser
                  65                  70                  75

 cat tgt tgg ata agc gag atg gta gta caa ttg tca gac agc ttg act      408
 His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser Leu Thr
              80                  85                  90

 gat ctt ctg gac aag ttt tca aat att tct gaa ggc ttg agt aat tat      456
 Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser Asn Tyr
          95                 100                 105

 tcc atc ata gac aaa ctt gtg aat ata gtg gat gac ctt gtg gag tgc      504
 Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val Glu Cys
     110                 115                 120

 gtg aaa gaa aac tca tct aag gat cta aaa aaa tca ttc aag agc cca      552
 Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys Ser Pro
 125                 130                 135                 140

 gaa ccc agg ctc ttt act cct gaa gaa ttc ttt aga att ttt aat aga      600
 Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe Asn Arg
                 145                 150                 155

 tcc att gat gcc ttc aag gac ttt gta gtg gca tct gaa act agt gat      648
 Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr Ser Asp
             160                 165                 170

 tgt gtg gtt tct tca aca tta agt cct gag aaa gat tcc aga gtc agt      696
 Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Asp Ser Arg Val Ser
         175                 180                 185

 gtc aca aaa cca ttt atg tta ccc cct gtt gca gcc agc tcc ctt agg      744
 Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala Ala Ser Ser Leu Arg
     190                 195                 200

 aat gac agc agt agc agt aat agg aag gca tgg att                      780
 Asn Asp Ser Ser Ser Ser Asn Arg Lys Ala Trp Ile 
 205                 210                 215





      <210> 344
      <211> 2206
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(2088)

      <400> 344
 aattcagcgg ccgctgaatt ctagcgccgg cctgggcccc tcggcagtgc caggtgtgga     60

 tccatggggt agcctcaacg catctgcccc tccaccccag ccagctcatg ggccacgtgg    120

 cctggcccag cctcagcacc cagggccagt gaacagagcc ctggctggag tccaaac       177                                                                 
 atg tgg ggc ctg gtg agg ctc ctg ctg gcc tgg ctg ggt ggc tgg ggc      225
 Met Trp Gly Leu Val Arg Leu Leu Leu Ala Trp Leu Gly Gly Trp Gly
   1               5                  10                  15

 tgc atg ggg cgt ctg gca gcc cca gcc cgg gcc tgg gca ggg tcc cgg      273
 Cys Met Gly Arg Leu Ala Ala Pro Ala Arg Ala Trp Ala Gly Ser Arg
              20                  25                  30

 gaa cac cca ggg cct gct ctg ctg cgg act cga agg agc tgg gtc tgg      321
 Glu His Pro Gly Pro Ala Leu Leu Arg Thr Arg Arg Ser Trp Val Trp
          35                  40                  45

 aac cag ttc ttt gtc att gag gaa tat gct ggt cca gag cct gtt ctc      369
 Asn Gln Phe Phe Val Ile Glu Glu Tyr Ala Gly Pro Glu Pro Val Leu
      50                  55                  60

 att ggc aag ctg cac tcg gat gtt gac cgg gga gag ggc cgc acc aag      417
 Ile Gly Lys Leu His Ser Asp Val Asp Arg Gly Glu Gly Arg Thr Lys
  65                  70                  75                  80

 tac ctg ttg acc ggg gag ggg gca ggc acc gta ttt gtg att gat gag      465
 Tyr Leu Leu Thr Gly Glu Gly Ala Gly Thr Val Phe Val Ile Asp Glu
                  85                  90                  95

 gcc aca ggc aat att cat gtt acc aag agc ctt gac cgg gag gaa aag      513
 Ala Thr Gly Asn Ile His Val Thr Lys Ser Leu Asp Arg Glu Glu Lys
             100                 105                 110

 gcg caa tat gtg cta ctg gcc caa gcc gtg gac cga gcc tcc aac cgg      561
 Ala Gln Tyr Val Leu Leu Ala Gln Ala Val Asp Arg Ala Ser Asn Arg
         115                 120                 125

 ccc ctg gag ccc cca tca gag ttc atc atc aaa ggg caa gac atc aac      609
 Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Gly Gln Asp Ile Asn
     130                 135                 140

 gac aat cca ccc att ttt ccc ctt ggg ccc tac cat gcc acc gtg ccc      657
 Asp Asn Pro Pro Ile Phe Pro Leu Gly Pro Tyr His Ala Thr Val Pro
 145                 150                 155                 160

 gag atg tcc aat gtc ggg aca tca gtg atc cag gtg act gct cac gat      705
 Glu Met Ser Asn Val Gly Thr Ser Val Ile Gln Val Thr Ala His Asp
                 165                 170                 175

 gct gat gac ccc agc tat ggg aac agt gcc aag ctg gtg tac act gtt      753
 Ala Asp Asp Pro Ser Tyr Gly Asn Ser Ala Lys Leu Val Tyr Thr Val
             180                 185                 190

 ctg gat gga ctg cct ttc ttc tct gtg gac ccc cag act gga gtg gtg      801
 Leu Asp Gly Leu Pro Phe Phe Ser Val Asp Pro Gln Thr Gly Val Val
         195                 200                 205

 cgt aca gcc atc ccc aac atg gac cgg gag aca cag gag gag ttc ttg      849
 Arg Thr Ala Ile Pro Asn Met Asp Arg Glu Thr Gln Glu Glu Phe Leu
     210                 215                 220

 gtg gtg atc cag gcc aag gac atg ggc ggc cac atg ggg ggg ctg tca      897
 Val Val Ile Gln Ala Lys Asp Met Gly Gly His Met Gly Gly Leu Ser
 225                 230                 235                 240

 ggc agc act acg gtg act gtc acg ctc agc gat gtc aac gac aac ccc      945
 Gly Ser Thr Thr Val Thr Val Thr Leu Ser Asp Val Asn Asp Asn Pro
                 245                 250                 255

 ccc aag ttc cca cag agc cta tac cag ttc tcc gtg gtg gag aca gct      993
 Pro Lys Phe Pro Gln Ser Leu Tyr Gln Phe Ser Val Val Glu Thr Ala
             260                 265                 270

 gga cct ggc aca ctg gtg ggc cgg ctc cgg gcc cag gac cca gac ctg     1041
 Gly Pro Gly Thr Leu Val Gly Arg Leu Arg Ala Gln Asp Pro Asp Leu
         275                 280                 285

 ggg gac aac gcc ctg atg gca tac agc atc ctg gat ggg gag ggg tct     1089
 Gly Asp Asn Ala Leu Met Ala Tyr Ser Ile Leu Asp Gly Glu Gly Ser
     290                 295                 300

 gag gcc ttc agc atc agc aca gac ttg cag ggt cga gac ggg ctc ctc     1137
 Glu Ala Phe Ser Ile Ser Thr Asp Leu Gln Gly Arg Asp Gly Leu Leu
 305                 310                 315                 320

 act gtc cgc aag ccc cta gac ttt gag agc cag cgc tcc tac tcc ttc     1185
 Thr Val Arg Lys Pro Leu Asp Phe Glu Ser Gln Arg Ser Tyr Ser Phe
                 325                 330                 335

 cgt gtc gag gcc acc aac acg ctc att gac cca gcc tat ctg cgg cga     1233
 Arg Val Glu Ala Thr Asn Thr Leu Ile Asp Pro Ala Tyr Leu Arg Arg
             340                 345                 350

 ggg ccc ttc aag gat gtg gcc tct gtg cgt gtg gca gtg caa gat gcc     1281
 Gly Pro Phe Lys Asp Val Ala Ser Val Arg Val Ala Val Gln Asp Ala
         355                 360                 365

 cca gag cca cct gcc ttc acc cag gct gcc tac cac ctg aca gtg cct     1329
 Pro Glu Pro Pro Ala Phe Thr Gln Ala Ala Tyr His Leu Thr Val Pro
     370                 375                 380

 gag aac aag gcc ccg ggg acc ctg gta ggc cag atc tcc gcg gct gac     1377
 Glu Asn Lys Ala Pro Gly Thr Leu Val Gly Gln Ile Ser Ala Ala Asp
 385                 390                 395                 400

 ctg gac tcc cct gcc agc cca atc aga tac tcc atc ctc ccc cac tca     1425
 Leu Asp Ser Pro Ala Ser Pro Ile Arg Tyr Ser Ile Leu Pro His Ser
                 405                 410                 415

 gat ccg gag cgt tgc ttc tct atc cag ccc gag gaa ggc acc atc cat     1473
 Asp Pro Glu Arg Cys Phe Ser Ile Gln Pro Glu Glu Gly Thr Ile His
             420                 425                 430

 aca gca gca ccc ctg gat cgc gag gct cgc gcc tgg cac aac ctc act     1521
 Thr Ala Ala Pro Leu Asp Arg Glu Ala Arg Ala Trp His Asn Leu Thr
         435                 440                 445

 gtg ctg gct aca gag ctc ggc tgg agc tgg ggg cca gaa agg ggc tgg     1569
 Val Leu Ala Thr Glu Leu Gly Trp Ser Trp Gly Pro Glu Arg Gly Trp
     450                 455                 460

 gta cct ctt ctg gtt gct gag tgg agt gca cca gca gcc cca ccc cag     1617
 Val Pro Leu Leu Val Ala Glu Trp Ser Ala Pro Ala Ala Pro Pro Gln
 465                 470                 475                 480

 aga agc cct gtt gga agc gct gtg gga atc ccc caa gac agt tct gca     1665
 Arg Ser Pro Val Gly Ser Ala Val Gly Ile Pro Gln Asp Ser Ser Ala
                 485                 490                 495

 cag gcc tcg cgc gtg caa gtg gcc atc cag acc ctg gat gag aat gac     1713
 Gln Ala Ser Arg Val Gln Val Ala Ile Gln Thr Leu Asp Glu Asn Asp
             500                 505                 510

 aat gct ccc cag ctg gct gag ccc tac gat act ttt gtg tgt gac tct     1761
 Asn Ala Pro Gln Leu Ala Glu Pro Tyr Asp Thr Phe Val Cys Asp Ser
         515                 520                 525

 gca gct cct ggc cag ctg att cag gtc atc cgg gcc ctg gac aga gat     1809
 Ala Ala Pro Gly Gln Leu Ile Gln Val Ile Arg Ala Leu Asp Arg Asp
     530                 535                 540

 gaa gtt ggc aac agt agc cat gtc tcc ttt caa ggt cct ctg ggc cct     1857
 Glu Val Gly Asn Ser Ser His Val Ser Phe Gln Gly Pro Leu Gly Pro
 545                 550                 555                 560

 gat gcc aac ttt act gtc cag gac aac cga gac ctg cct gca tgg ttc     1905
 Asp Ala Asn Phe Thr Val Gln Asp Asn Arg Asp Leu Pro Ala Trp Phe
                 565                 570                 575

 cat cca tta ctc atg gcc tca gcc tca tcc tgg ctc cac tgg cct cca     1953
 His Pro Leu Leu Met Ala Ser Ala Ser Ser Trp Leu His Trp Pro Pro
             580                 585                 590

 gct gag aga ggg aac cag cct gcc tcc cag ggc aag agc tcc agc ctc     2001
 Ala Glu Arg Gly Asn Gln Pro Ala Ser Gln Gly Lys Ser Ser Ser Leu
         595                 600                 605

 ccg tgt ggc cgc ctc cct gga gct ctg ccc agc tgt cag ctt ccc ctg     2049
 Pro Cys Gly Arg Leu Pro Gly Ala Leu Pro Ser Cys Gln Leu Pro Leu
     610                 615                 620

 ggc atc cca gcc ctg ggc att gtc ttg tgt gct tcc tga gggagtaggg      2098
 Gly Ile Pro Ala Leu Gly Ile Val Leu Cys Ala Ser 
 625                 630                 635

 aaaggaaagg gggaggcggc tggggaaggg gaaagaggga ggaaggggag gggcctccat   2158

 ctctaatttc ataataaaca aacactttat tttgtaaaaa aaaaaaaa                2206




      <210> 345
      <211> 2006
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(1974)

      <400> 345
 aattcagcgg ccgctgaatt ctagcgccgg cctgggcccc tcggcagtgc caggtgtgga     60

 tccatggggt agcctcaacg catctgcccc tccaccccag ccagctcatg ggccacgtgg    120

 cctggcccag cctcagcacc cagggccagt gaacagagcc ctggctggag tccaaac       177                                                                 
 atg tgg ggc ctg gtg agg ctc ctg ctg gcc tgg ctg ggt ggc tgg ggc      225
 Met Trp Gly Leu Val Arg Leu Leu Leu Ala Trp Leu Gly Gly Trp Gly
   1               5                  10                  15

 tgc atg ggg cgt ctg gca gcc cca gcc cgg gcc tgg gca ggg tcc cgg      273
 Cys Met Gly Arg Leu Ala Ala Pro Ala Arg Ala Trp Ala Gly Ser Arg
              20                  25                  30

 gaa cac cca ggg cct gct ctg ctg cgg act cga agg agc tgg gtc tgg      321
 Glu His Pro Gly Pro Ala Leu Leu Arg Thr Arg Arg Ser Trp Val Trp
          35                  40                  45

 aac cag ttc ttt gtc att gag gaa tat gct ggt cca gag cct gtt ctc      369
 Asn Gln Phe Phe Val Ile Glu Glu Tyr Ala Gly Pro Glu Pro Val Leu
      50                  55                  60

 att ggc aag ctg cac tcg gat gtt gac cgg gga gag ggc cgc acc aag      417
 Ile Gly Lys Leu His Ser Asp Val Asp Arg Gly Glu Gly Arg Thr Lys
  65                  70                  75                  80

 tac ctg ttg acc ggg gag ggg gca ggc acc gta ttt gtg att gat gag      465
 Tyr Leu Leu Thr Gly Glu Gly Ala Gly Thr Val Phe Val Ile Asp Glu
                  85                  90                  95

 gcc aca ggc aat att cat gtt acc aag agc ctt gac cgg gag gaa aag      513
 Ala Thr Gly Asn Ile His Val Thr Lys Ser Leu Asp Arg Glu Glu Lys
             100                 105                 110

 gcg caa tat gtg cta ctg gcc caa gcc gtg gac cga gcc tcc aac cgg      561
 Ala Gln Tyr Val Leu Leu Ala Gln Ala Val Asp Arg Ala Ser Asn Arg
         115                 120                 125

 ccc ctg gag ccc cca tca gag ttc atc atc aaa ggg caa gac atc aac      609
 Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Gly Gln Asp Ile Asn
     130                 135                 140

 gac aat cca ccc att ttt ccc ctt ggg ccc tac cat gcc acc gtg ccc      657
 Asp Asn Pro Pro Ile Phe Pro Leu Gly Pro Tyr His Ala Thr Val Pro
 145                 150                 155                 160

 gag atg tcc aat gtc ggg aca tca gtg atc cag gtg act gct cac gat      705
 Glu Met Ser Asn Val Gly Thr Ser Val Ile Gln Val Thr Ala His Asp
                 165                 170                 175

 gct gat gac ccc agc tat ggg aac agt gcc aag ctg gtg tac act gtt      753
 Ala Asp Asp Pro Ser Tyr Gly Asn Ser Ala Lys Leu Val Tyr Thr Val
             180                 185                 190

 ctg gat gga ctg cct ttc ttc tct gtg gac ccc cag act gga gtg gtg      801
 Leu Asp Gly Leu Pro Phe Phe Ser Val Asp Pro Gln Thr Gly Val Val
         195                 200                 205

 cgt aca gcc atc ccc aac atg gac cgg gag aca cag gag gag ttc ttg      849
 Arg Thr Ala Ile Pro Asn Met Asp Arg Glu Thr Gln Glu Glu Phe Leu
     210                 215                 220

 gtg gtg atc cag gcc aag gac atg ggc ggc cac atg ggg ggg ctg tca      897
 Val Val Ile Gln Ala Lys Asp Met Gly Gly His Met Gly Gly Leu Ser
 225                 230                 235                 240

 ggc agc act acg gtg act gtc acg ctc agc gat gtc aac gac aac ccc      945
 Gly Ser Thr Thr Val Thr Val Thr Leu Ser Asp Val Asn Asp Asn Pro
                 245                 250                 255

 ccc aag ttc cca cag agc cta tac cag ttc tcc gtg gtg gag aca gct      993
 Pro Lys Phe Pro Gln Ser Leu Tyr Gln Phe Ser Val Val Glu Thr Ala
             260                 265                 270

 gga cct ggc aca ctg gtg ggc cgg ctc cgg gcc cag gac cca gac ctg     1041
 Gly Pro Gly Thr Leu Val Gly Arg Leu Arg Ala Gln Asp Pro Asp Leu
         275                 280                 285

 ggg gac aac gcc ctg atg gca tac agc atc ctg gat ggg gag ggg tct     1089
 Gly Asp Asn Ala Leu Met Ala Tyr Ser Ile Leu Asp Gly Glu Gly Ser
     290                 295                 300

 gag gcc ttc agc atc agc aca gac ttg cag ggt cga gac ggg ctc ctc     1137
 Glu Ala Phe Ser Ile Ser Thr Asp Leu Gln Gly Arg Asp Gly Leu Leu
 305                 310                 315                 320

 act gtc cgc aag ccc cta gac ttt gag agc cag cgc tcc tac tcc ttc     1185
 Thr Val Arg Lys Pro Leu Asp Phe Glu Ser Gln Arg Ser Tyr Ser Phe
                 325                 330                 335

 cgt gtc gag gcc acc aac acg ctc att gac cca gcc tat ctg cgg cga     1233
 Arg Val Glu Ala Thr Asn Thr Leu Ile Asp Pro Ala Tyr Leu Arg Arg
             340                 345                 350

 ggg ccc ttc aag gat gtg gcc tct gtg cgt gtg gca gtg caa gat gcc     1281
 Gly Pro Phe Lys Asp Val Ala Ser Val Arg Val Ala Val Gln Asp Ala
         355                 360                 365

 cca gag cca cct gcc ttc acc cag gct gcc tac cac ctg aca gtg cct     1329
 Pro Glu Pro Pro Ala Phe Thr Gln Ala Ala Tyr His Leu Thr Val Pro
     370                 375                 380

 gag aac aag gcc ccg ggg acc ctg gta ggc cag atc tcc gcg gct gac     1377
 Glu Asn Lys Ala Pro Gly Thr Leu Val Gly Gln Ile Ser Ala Ala Asp
 385                 390                 395                 400

 ctg gac tcc cct gcc agc cca atc aga tac tcc atc ctc ccc cac tca     1425
 Leu Asp Ser Pro Ala Ser Pro Ile Arg Tyr Ser Ile Leu Pro His Ser
                 405                 410                 415

 gat ccg gag cgt tgc ttc tct atc cag ccc gag gaa ggc acc atc cat     1473
 Asp Pro Glu Arg Cys Phe Ser Ile Gln Pro Glu Glu Gly Thr Ile His
             420                 425                 430

 aca gca gca ccc ctg gat cgc gag gct cgc gcc tgg cac aac ctc act     1521
 Thr Ala Ala Pro Leu Asp Arg Glu Ala Arg Ala Trp His Asn Leu Thr
         435                 440                 445

 gtg ctg gct aca gag ctc gac agt tct gca cag gcc tcg cgc gtg caa     1569
 Val Leu Ala Thr Glu Leu Asp Ser Ser Ala Gln Ala Ser Arg Val Gln
     450                 455                 460

 gtg gcc atc cag acc ctg gat gag aat gac aat gct ccc cag ctg gct     1617
 Val Ala Ile Gln Thr Leu Asp Glu Asn Asp Asn Ala Pro Gln Leu Ala
 465                 470                 475                 480

 gag ccc tac gat act ttt gtg tgt gac tct gca gct cct ggc cag ctg     1665
 Glu Pro Tyr Asp Thr Phe Val Cys Asp Ser Ala Ala Pro Gly Gln Leu
                 485                 490                 495

 att cag gtc atc cgg gcc ctg gac aga gat gaa gtt ggc aac agt agc     1713
 Ile Gln Val Ile Arg Ala Leu Asp Arg Asp Glu Val Gly Asn Ser Ser
             500                 505                 510

 cat gtc tcc ttt caa ggt cct ctg ggc cct gat gcc aac ttt act gtc     1761
 His Val Ser Phe Gln Gly Pro Leu Gly Pro Asp Ala Asn Phe Thr Val
         515                 520                 525

 cag gac aac cga gac ctg cct gca tgg ttc cat cca tta ctc atg gcc     1809
 Gln Asp Asn Arg Asp Leu Pro Ala Trp Phe His Pro Leu Leu Met Ala
     530                 535                 540

 tca gcc tca tcc tgg ctc cac tgg cct cca gct gag aga ggg aac cag     1857
 Ser Ala Ser Ser Trp Leu His Trp Pro Pro Ala Glu Arg Gly Asn Gln
 545                 550                 555                 560

 cct gcc tcc cag ggc aag agc tcc agc ctc ccg tgt ggc cgc ctc cct     1905
 Pro Ala Ser Gln Gly Lys Ser Ser Ser Leu Pro Cys Gly Arg Leu Pro
                 565                 570                 575

 gga gct ctg ccc agc tgt cag ctt ccc ctg ggc atc cca gcc ctg ggc     1953
 Gly Ala Leu Pro Ser Cys Gln Leu Pro Leu Gly Ile Pro Ala Leu Gly
             580                 585                 590

 att gtc ttg tgt gct tcc tga gg gagtagggaa aggaaagggg gaggcggctg     2006
 Ile Val Leu Cys Ala Ser 
         595





      <210> 346
      <211> 5471
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (351)..(4412)

      <400> 346
 acagcttgca acactcggca tcttttctgg aggcgcctcc ttcagcagcc gcagatggca     60

 tccggctgcg ggctcggggc tcgcaattga ttctccccct tgcccacctc gagtccacgg    120

 acgcacctct cccttcccct cctcccttcg cgcttctggg tctgagccca gctcgcgacc    180

 gccgggcaga ggatcagtcg cggcggccga ggctgagcag cagcgctctc gctccctgac    240

 ctggggagaa gcgcccaccc gggagagctg atccccggct gcctccagcg ccccccacct    300

 tttgcactcc aagccggggg ctccagagac cccgctcccc aggcgccact   atg ctg     356
                                                          Met Leu
                                                            1

 gac cct tcg tcc agc gaa gaa gaa tcg gat gag atc gtg gag gag gag      404
 Asp Pro Ser Ser Ser Glu Glu Glu Ser Asp Glu Ile Val Glu Glu Glu
           5                  10                  15

 agc ggc aag gag gtg ctc ggc tcg gcc ccg tcc ggc gcg cgc ctg tct      452
 Ser Gly Lys Glu Val Leu Gly Ser Ala Pro Ser Gly Ala Arg Leu Ser
      20                  25                  30

 ccc agc cgt acc agc gag ggc tcg gcc ggc agc gcc ggg ctg ggg ggc      500
 Pro Ser Arg Thr Ser Glu Gly Ser Ala Gly Ser Ala Gly Leu Gly Gly
  35                  40                  45                  50

 ggc ggc gcc ggc gcc gga gcc ggg gtg ggt gca ggc ggc ggc ggg ggc      548
 Gly Gly Ala Gly Ala Gly Ala Gly Val Gly Ala Gly Gly Gly Gly Gly
                  55                  60                  65

 agc ggc gcg agc agc ggc ggc ggg gcc ggg ggg ctg caa ccc agc agc      596
 Ser Gly Ala Ser Ser Gly Gly Gly Ala Gly Gly Leu Gln Pro Ser Ser
              70                  75                  80

 cgc gct ggc ggc ggc cgg ccc tcc agc ccc agc ccg tcg gtg gtg agc      644
 Arg Ala Gly Gly Gly Arg Pro Ser Ser Pro Ser Pro Ser Val Val Ser
          85                  90                  95

 gag aag gag aag gaa gag ttg gag cgg ctg cag aaa gag gag gag gag      692
 Glu Lys Glu Lys Glu Glu Leu Glu Arg Leu Gln Lys Glu Glu Glu Glu
     100                 105                 110

 agg aag aag agg ctg cag ctg tat gtg ttc gtg atg cgc tgc atc gcc      740
 Arg Lys Lys Arg Leu Gln Leu Tyr Val Phe Val Met Arg Cys Ile Ala
 115                 120                 125                 130

 tac ccc ttt aat gcc aag cag ccc acc gac atg gct cgc cgg cag cag      788
 Tyr Pro Phe Asn Ala Lys Gln Pro Thr Asp Met Ala Arg Arg Gln Gln
                 135                 140                 145

 aag atc agc aaa cag cag ctg cag aca gtc aag gac cgg ttt cag gct      836
 Lys Ile Ser Lys Gln Gln Leu Gln Thr Val Lys Asp Arg Phe Gln Ala
             150                 155                 160

 ttc ctc aat ggg gaa acc cag atc atg gct gac gaa gcc ttc atg aac      884
 Phe Leu Asn Gly Glu Thr Gln Ile Met Ala Asp Glu Ala Phe Met Asn
         165                 170                 175

 gct gtg cag agt tac tat gag gtg ttc ctg aag agc gac cgt gtg gcc      932
 Ala Val Gln Ser Tyr Tyr Glu Val Phe Leu Lys Ser Asp Arg Val Ala
     180                 185                 190

 cgc atg gtt cag agt gga ggc tgt tcc gcc aac gac tcc cgg gag gtc      980
 Arg Met Val Gln Ser Gly Gly Cys Ser Ala Asn Asp Ser Arg Glu Val
 195                 200                 205                 210

 ttc aag aag cac att gag aag aga gtg cgc agc ctg cct gag att gac     1028
 Phe Lys Lys His Ile Glu Lys Arg Val Arg Ser Leu Pro Glu Ile Asp
                 215                 220                 225

 ggc ctc agc aag gag act gtg ctg agc tcc tgg atg gcc aaa ttt gat     1076
 Gly Leu Ser Lys Glu Thr Val Leu Ser Ser Trp Met Ala Lys Phe Asp
             230                 235                 240

 gcc atc tac cgt gga gaa gag gac ccg cgg aag cag cag gcc cgg atg     1124
 Ala Ile Tyr Arg Gly Glu Glu Asp Pro Arg Lys Gln Gln Ala Arg Met
         245                 250                 255

 aca gcc agc gca gcc tcc gag ctg att ctg agc aag gag caa ctc tat     1172
 Thr Ala Ser Ala Ala Ser Glu Leu Ile Leu Ser Lys Glu Gln Leu Tyr
     260                 265                 270

 gag atg ttc cag aac att ctt ggg atc aag aag ttc gaa cat cag ctc     1220
 Glu Met Phe Gln Asn Ile Leu Gly Ile Lys Lys Phe Glu His Gln Leu
 275                 280                 285                 290

 ctt tac aat gcc tgc cag ctg gac aat cca gat gag caa gca gcc cag     1268
 Leu Tyr Asn Ala Cys Gln Leu Asp Asn Pro Asp Glu Gln Ala Ala Gln
                 295                 300                 305

 atc aga cga gag ctg gat gga cgt cta caa atg gca gac caa ata gcc     1316
 Ile Arg Arg Glu Leu Asp Gly Arg Leu Gln Met Ala Asp Gln Ile Ala
             310                 315                 320

 agg gaa cgc aaa ttt ccc aag ttt gta tcc aaa gaa atg gaa aac atg     1364
 Arg Glu Arg Lys Phe Pro Lys Phe Val Ser Lys Glu Met Glu Asn Met
         325                 330                 335

 tac att gag gag ctg aag tca tct gtc aac ctg ctc atg gcc aac ttg     1412
 Tyr Ile Glu Glu Leu Lys Ser Ser Val Asn Leu Leu Met Ala Asn Leu
     340                 345                 350

 gag agc atg ccg gta tcc aaa ggc ggg gag ttc aag ctc cag aaa ctc     1460
 Glu Ser Met Pro Val Ser Lys Gly Gly Glu Phe Lys Leu Gln Lys Leu
 355                 360                 365                 370

 aaa cgc agc cac aat gct tcc atc atc gac atg ggc gag gag agt gag     1508
 Lys Arg Ser His Asn Ala Ser Ile Ile Asp Met Gly Glu Glu Ser Glu
                 375                 380                 385

 aac cag ctc tcc aag tca gat gtc gtg ctg tct ttc tca ttg gag gtg     1556
 Asn Gln Leu Ser Lys Ser Asp Val Val Leu Ser Phe Ser Leu Glu Val
             390                 395                 400

 gta att atg gaa gtc caa ggc ctc aaa tct ttg gct cca aat cgc atc     1604
 Val Ile Met Glu Val Gln Gly Leu Lys Ser Leu Ala Pro Asn Arg Ile
         405                 410                 415

 gta tat tgc aca atg gag gtg gaa gga gga gag aaa cta cag act gat     1652
 Val Tyr Cys Thr Met Glu Val Glu Gly Gly Glu Lys Leu Gln Thr Asp
     420                 425                 430

 cag gcc gag gct tct aaa cca acc tgg ggc acc cag ggt gac ttc tcc     1700
 Gln Ala Glu Ala Ser Lys Pro Thr Trp Gly Thr Gln Gly Asp Phe Ser
 435                 440                 445                 450

 aca acc cat gca ctg cca gct gtg aag gtg aag ctg ttc aca gag agc     1748
 Thr Thr His Ala Leu Pro Ala Val Lys Val Lys Leu Phe Thr Glu Ser
                 455                 460                 465

 aca ggc gtc ctg gcg ttg gag gac aag gag ctt ggg cgg gtt att ctc     1796
 Thr Gly Val Leu Ala Leu Glu Asp Lys Glu Leu Gly Arg Val Ile Leu
             470                 475                 480

 cat ccc acc ccg aac agc ccc aaa cag tca gag tgg cac aaa atg aca     1844
 His Pro Thr Pro Asn Ser Pro Lys Gln Ser Glu Trp His Lys Met Thr
         485                 490                 495

 gtc tcc aaa aac tgc ccc gac caa gat ctc aaa atc aaa ctt gct gtc     1892
 Val Ser Lys Asn Cys Pro Asp Gln Asp Leu Lys Ile Lys Leu Ala Val
     500                 505                 510

 cga atg gat aag cct caa aac atg aag cat tct ggg tat tta tgg gcc     1940
 Arg Met Asp Lys Pro Gln Asn Met Lys His Ser Gly Tyr Leu Trp Ala
 515                 520                 525                 530

 atc ggt aag aat gtc tgg aag aga tgg aag aaa agg ttt ttt gta ttg     1988
 Ile Gly Lys Asn Val Trp Lys Arg Trp Lys Lys Arg Phe Phe Val Leu
                 535                 540                 545

 gtg cag gtc agt cag tac acg ttt gcc atg tgc agt tat cgg gag aag     2036
 Val Gln Val Ser Gln Tyr Thr Phe Ala Met Cys Ser Tyr Arg Glu Lys
             550                 555                 560

 aaa gcg gag cct cag gaa ctt cta caa ttg gat ggc tac act gtg gat     2084
 Lys Ala Glu Pro Gln Glu Leu Leu Gln Leu Asp Gly Tyr Thr Val Asp
         565                 570                 575

 tac acc gac ccc cag cca ggt ttg gag ggt ggc cga gcc ttc ttc aat     2132
 Tyr Thr Asp Pro Gln Pro Gly Leu Glu Gly Gly Arg Ala Phe Phe Asn
     580                 585                 590

 gct gtc aag gag gga gac acc gtg ata ttt gcc agt gac gat gaa caa     2180
 Ala Val Lys Glu Gly Asp Thr Val Ile Phe Ala Ser Asp Asp Glu Gln
 595                 600                 605                 610

 gac cgc atc ctg tgg gtc cag gcc atg tat cgg gcc acg ggg cag tca     2228
 Asp Arg Ile Leu Trp Val Gln Ala Met Tyr Arg Ala Thr Gly Gln Ser
                 615                 620                 625

 cac aag cct gtg ccc ccg acc caa gtc cag aaa ctc aac gcc aag gga     2276
 His Lys Pro Val Pro Pro Thr Gln Val Gln Lys Leu Asn Ala Lys Gly
             630                 635                 640

 gga aat gta cct cag ctg gat gcc cct atc tct caa ttt tac gca gat     2324
 Gly Asn Val Pro Gln Leu Asp Ala Pro Ile Ser Gln Phe Tyr Ala Asp
         645                 650                 655

 aga gct caa aaa cat ggc atg gat gaa ttt atc tct tcc aac ccc tgt     2372
 Arg Ala Gln Lys His Gly Met Asp Glu Phe Ile Ser Ser Asn Pro Cys
     660                 665                 670

 aac ttt gac cac gct tcc ctc ttt gag atg gta caa cgc ctt act ttg     2420
 Asn Phe Asp His Ala Ser Leu Phe Glu Met Val Gln Arg Leu Thr Leu
 675                 680                 685                 690

 gat cac aga ctt aat gat tcc tat tct tgc ctg ggc tgg ttc agt cct     2468
 Asp His Arg Leu Asn Asp Ser Tyr Ser Cys Leu Gly Trp Phe Ser Pro
                 695                 700                 705

 ggc cag gtg ttt gta cta gac gag tat tgc gcc cga aat gga gtc cgg     2516
 Gly Gln Val Phe Val Leu Asp Glu Tyr Cys Ala Arg Asn Gly Val Arg
             710                 715                 720

 ggg tgt cac cga cat ctc tgc tac ctc aga gac ttg ctt gaa cgg gca     2564
 Gly Cys His Arg His Leu Cys Tyr Leu Arg Asp Leu Leu Glu Arg Ala
         725                 730                 735

 gaa aat ggc gcc atg atc gac ccc acc ctt ctt cac tac agc ttt gcc     2612
 Glu Asn Gly Ala Met Ile Asp Pro Thr Leu Leu His Tyr Ser Phe Ala
     740                 745                 750

 ttc tgt gca tcc cat gtc cat ggg aac agg cct gat gga att gga act     2660
 Phe Cys Ala Ser His Val His Gly Asn Arg Pro Asp Gly Ile Gly Thr
 755                 760                 765                 770

 gtg act gtt gaa gaa aag gaa cgt ttt gaa gaa atc aaa gag agg ctc     2708
 Val Thr Val Glu Glu Lys Glu Arg Phe Glu Glu Ile Lys Glu Arg Leu
                 775                 780                 785

 cga gtt ctg cta gaa aat cag att aca cat ttt agg tat tgc ttt cca     2756
 Arg Val Leu Leu Glu Asn Gln Ile Thr His Phe Arg Tyr Cys Phe Pro
             790                 795                 800

 ttt ggt cga cct gaa ggt gct ttg aaa gct act ctc tca ctc ttg gaa     2804
 Phe Gly Arg Pro Glu Gly Ala Leu Lys Ala Thr Leu Ser Leu Leu Glu
         805                 810                 815

 agg gtt ttg atg aaa gat att gtt acc cca gtg cca caa gag gag gta     2852
 Arg Val Leu Met Lys Asp Ile Val Thr Pro Val Pro Gln Glu Glu Val
     820                 825                 830

 aaa aca gtt atc cgt aaa tgt ctg gaa cag gct gcg tta gtc aac tat     2900
 Lys Thr Val Ile Arg Lys Cys Leu Glu Gln Ala Ala Leu Val Asn Tyr
 835                 840                 845                 850

 tct cgg ctc tca gag tat gcc aaa atc gaa gag aat caa aag gat gca     2948
 Ser Arg Leu Ser Glu Tyr Ala Lys Ile Glu Glu Asn Gln Lys Asp Ala
                 855                 860                 865

 gaa aat gta ggc cgg tta atc act cct gcc aaa aag ctt gaa gat aca     2996
 Glu Asn Val Gly Arg Leu Ile Thr Pro Ala Lys Lys Leu Glu Asp Thr
             870                 875                 880

 ata cgt ctt gct gaa cta gtc att gaa gtt ctt cag caa aat gag gag     3044
 Ile Arg Leu Ala Glu Leu Val Ile Glu Val Leu Gln Gln Asn Glu Glu
         885                 890                 895

 cac cac gca gag cca cat gtt gat aaa gga gaa gcc ttt gcg tgg tgg     3092
 His His Ala Glu Pro His Val Asp Lys Gly Glu Ala Phe Ala Trp Trp
     900                 905                 910

 tca gat tta atg gtg gag cat gcg gag acg ttc ctg tca ctc ttt gca     3140
 Ser Asp Leu Met Val Glu His Ala Glu Thr Phe Leu Ser Leu Phe Ala
 915                 920                 925                 930

 gta gac atg gat gca gcc tta gag gtg caa cct cca gac aca tgg gac     3188
 Val Asp Met Asp Ala Ala Leu Glu Val Gln Pro Pro Asp Thr Trp Asp
                 935                 940                 945

 agt ttt cca cta ttt cag ctg ctg aat gat ttt ctc cgt act gac tat     3236
 Ser Phe Pro Leu Phe Gln Leu Leu Asn Asp Phe Leu Arg Thr Asp Tyr
             950                 955                 960

 aat ttg tgc aat gga aaa ttt cac aaa cac ctg caa gac ctg ttt gcc     3284
 Asn Leu Cys Asn Gly Lys Phe His Lys His Leu Gln Asp Leu Phe Ala
         965                 970                 975

 cca ctt gtt gtt aga tat gtg gat ctg atg gag tcc tca att gca caa     3332
 Pro Leu Val Val Arg Tyr Val Asp Leu Met Glu Ser Ser Ile Ala Gln
     980                 985                 990

 tcc att cac agg ggc ttt gag cgg gag tca tgg gaa cca gtc aag agt     3380
 Ser Ile His Arg Gly Phe Glu Arg Glu Ser Trp Glu Pro Val Lys Ser
 995                1000                1005                1010

 tta acc agt aac cta ccc aat gtg aac cta ccc aat gtg aac ctt ccc     3428
 Leu Thr Ser Asn Leu Pro Asn Val Asn Leu Pro Asn Val Asn Leu Pro
                1015                1020                1025

 aaa gta cca aat cta cca gtt aac atc cct cta ggc atc cca caa atg     3476
 Lys Val Pro Asn Leu Pro Val Asn Ile Pro Leu Gly Ile Pro Gln Met
            1030                1035                1040

 cct act ttt tcg gca ccg tca tgg atg gct gct ata tat gat gcg gat     3524
 Pro Thr Phe Ser Ala Pro Ser Trp Met Ala Ala Ile Tyr Asp Ala Asp
        1045                1050                1055

 aat ggg tca ggc acc tca gaa gat ctg ttt tgg aaa ctt gac gcc ctt     3572
 Asn Gly Ser Gly Thr Ser Glu Asp Leu Phe Trp Lys Leu Asp Ala Leu
    1060                1065                1070

 cag acc ttc att cgg gac ctg cac tgg cct gaa gaa gag ttt gga aag     3620
 Gln Thr Phe Ile Arg Asp Leu His Trp Pro Glu Glu Glu Phe Gly Lys
1075                1080                1085                1090

 cac ctg gaa caa cgg ctg aag ttg atg gca agt gac atg atc gaa tct     3668
 His Leu Glu Gln Arg Leu Lys Leu Met Ala Ser Asp Met Ile Glu Ser
                1095                1100                1105

 tgt gtc aaa aga acc agg att gca ttt gaa gtt aag ctg caa aaa acc     3716
 Cys Val Lys Arg Thr Arg Ile Ala Phe Glu Val Lys Leu Gln Lys Thr
            1110                1115                1120

 agt cga tca aca gat ttt cga gtc cca cag tca ata tgc acc atg ttt     3764
 Ser Arg Ser Thr Asp Phe Arg Val Pro Gln Ser Ile Cys Thr Met Phe
        1125                1130                1135

 aat gtt atg gtt gat gcc aaa gct caa tca aca aaa ctt tgc agc atg     3812
 Asn Val Met Val Asp Ala Lys Ala Gln Ser Thr Lys Leu Cys Ser Met
    1140                1145                1150

 gaa atg ggc caa gag cat caa tac cat tca aaa ata gac gaa cta att     3860
 Glu Met Gly Gln Glu His Gln Tyr His Ser Lys Ile Asp Glu Leu Ile
1155                1160                1165                1170

 gaa gaa act gtt aaa gaa atg ata aca ctc ttg gtt gca aag ttc gtt     3908
 Glu Glu Thr Val Lys Glu Met Ile Thr Leu Leu Val Ala Lys Phe Val
                1175                1180                1185

 act atc ttg gaa gga gtg ctg gca aaa tta tcc aga tat gac gaa ggg     3956
 Thr Ile Leu Glu Gly Val Leu Ala Lys Leu Ser Arg Tyr Asp Glu Gly
            1190                1195                1200

 act ttg ttt tct tct ttt ctg tca ttt acc gtg aag gca gct tcc aaa     4004
 Thr Leu Phe Ser Ser Phe Leu Ser Phe Thr Val Lys Ala Ala Ser Lys
        1205                1210                1215

 tat gtg gat gta cct aaa ccc ggg atg gac gtg gcc gac gcc tac gtg     4052
 Tyr Val Asp Val Pro Lys Pro Gly Met Asp Val Ala Asp Ala Tyr Val
    1220                1225                1230

 act ttc gtc cgc cat tct cag gat gtc ctg cgt gat aag gtc aat gag     4100
 Thr Phe Val Arg His Ser Gln Asp Val Leu Arg Asp Lys Val Asn Glu
1235                1240                1245                1250

 gag atg tac ata gaa agg tta ttt gat caa tgg tac aac agc tcc atg     4148
 Glu Met Tyr Ile Glu Arg Leu Phe Asp Gln Trp Tyr Asn Ser Ser Met
                1255                1260                1265

 aac gtg atc tgc acc tgg ttg acg gac cgg atg gac tta cag ctt cat     4196
 Asn Val Ile Cys Thr Trp Leu Thr Asp Arg Met Asp Leu Gln Leu His
            1270                1275                1280

 att tat cag ttg aaa aca cta att agg gtg gta aag aaa acc tac aga     4244
 Ile Tyr Gln Leu Lys Thr Leu Ile Arg Val Val Lys Lys Thr Tyr Arg
        1285                1290                1295

 gat ttc cga ttg caa ggg gtc ctg gac tcc acc tta aac agc aag acc     4292
 Asp Phe Arg Leu Gln Gly Val Leu Asp Ser Thr Leu Asn Ser Lys Thr
    1300                1305                1310

 tat gaa acg atc cgg aac cgt ctc act gtg gag gaa gcc aca gca tca     4340
 Tyr Glu Thr Ile Arg Asn Arg Leu Thr Val Glu Glu Ala Thr Ala Ser
1315                1320                1325                1330

 gtg agt gaa ggt ggg gga ctg cag ggc atc agc atg aag gac agc gat     4388
 Val Ser Glu Gly Gly Gly Leu Gln Gly Ile Ser Met Lys Asp Ser Asp
                1335                1340                1345

 gag gaa gac gaa gaa gac gat tag accatttggt cctagagtct gctgggacag    4442
 Glu Glu Asp Glu Glu Asp Asp 
            1350

 agtcctgtaa tcagtgcatg tccttagtct gttagttaaa cccattagga attttctgtc   4502

 aactaccatg cccatgagat gtttatcaat acaactgcca ttttagctat gtggtaccaa   4562

 gattagcaaa tgaccttcat atccactgat ttcctgatgt ccatgtctat atgtttacaa   4622

 gcaatatgga gcaccattct ttaaatactg ttcatggaga atacatagtc taaccactag   4682

 gcgtgtccct gttatcagca aagatcaatg atgcttcatt catgtactat gtatgcattg   4742

 gtggtaaatg gatgtgaggg caagtacatc aagtacattc actctgtttc acgtatgtgg   4802

 atgccagtta attaaatgag tacgtaaata aattaattaa aacacataga tctgctttgt   4862

 gtttttattt ttattttttg aaaaacaaaa ggcaagtctc caacaattaa cttttgatgc   4922

 tttctgttcc cctaaaacca aaaaatgaac cccttgtgtc gttgttaacc catcctttca   4982

 tttactcata taattagcca aaaaaaaaag gatggctaca taccaatgga ttgattctct   5042

 taattgccac ggcaaggggg cgatcctatc atgacttaac atcaagcgcg cagttcaaaa   5102

 ctactgtctt ctgtcaaagt tttctcctct taaatgttat tttgctttta cgtctcaact   5162

 gtgtatgtaa aaaaaacgaa tatttaaatt acaaccctag actaaaaatg tgtttataat   5222

 aagatgtgga tatttccttc agtagattgt aaccataatt taaattattt tgttccacac   5282

 tgttttttat atctgtcatg tacattgcat tttgatctgt aactgcacaa ccctggggtt   5342

 tgctgcagag ctatttcttt ccatgtaaag tagtggatcc atcttgcttt tgccttatat   5402

 aaagcctaca gttatggaag tgtggaaaac tgtggcttct caataaatat tcagatgtcc   5462

 taagaatat                                                           5471




      <210> 347
      <211> 1522
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(1201)

      <400> 347
 tattttgaag ctgtttaccc tcgcagctct ctgactggca cccctgcctg cctgcccggc     60

 cctgcacaac   atg cag ccc tcc ggc ctc gag ggt ccc ggc acg ttt ggt     109
              Met Gln Pro Ser Gly Leu Glu Gly Pro Gly Thr Phe Gly
                1               5                  10

 cgg tgg cct ctg ctg agt ctg ctg ctc ctg ctg ctg ctg ctc cag cct      157
 Arg Trp Pro Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro
      15                  20                  25

 gta acc tgt gcc tac acc acg cca ggc ccc ccc aga gcc ctc acc acg      205
 Val Thr Cys Ala Tyr Thr Thr Pro Gly Pro Pro Arg Ala Leu Thr Thr
  30                  35                  40                  45

 ctg ggc gcc ccc aga gcc cac acc atg ccg ggc acc tac gct ccc tcg      253
 Leu Gly Ala Pro Arg Ala His Thr Met Pro Gly Thr Tyr Ala Pro Ser
                  50                  55                  60

 acc aca ctc agt agt ccc agc acc cag ggc ctg caa gag cag gca cgg      301
 Thr Thr Leu Ser Ser Pro Ser Thr Gln Gly Leu Gln Glu Gln Ala Arg
              65                  70                  75

 gcc ctg atg cgg gac ttc ccg ctc gtg gac ggc cac aac gac ctg ccc      349
 Ala Leu Met Arg Asp Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro
          80                  85                  90

 ctg gtc cta agg cag gtt tac cag aaa ggg cta cag gat gtt aac ctg      397
 Leu Val Leu Arg Gln Val Tyr Gln Lys Gly Leu Gln Asp Val Asn Leu
      95                 100                 105

 cgc aat ttc agc tac ggc cag acc agc ctg gac agg ctt aga gat ggc      445
 Arg Asn Phe Ser Tyr Gly Gln Thr Ser Leu Asp Arg Leu Arg Asp Gly
 110                 115                 120                 125

 ctc gtg ggc gcc cag ttc tgg tca gcc tat gtg cca tgc cag acc cag      493
 Leu Val Gly Ala Gln Phe Trp Ser Ala Tyr Val Pro Cys Gln Thr Gln
                 130                 135                 140

 gac cgg gat gcc ctg cgc ctc acc ctg gag cag att gac ctc ata cgc      541
 Asp Arg Asp Ala Leu Arg Leu Thr Leu Glu Gln Ile Asp Leu Ile Arg
             145                 150                 155

 cgc atg tgt gcc tcc tat tct gag ctg gag ctt gtg acc tcg gct aaa      589
 Arg Met Cys Ala Ser Tyr Ser Glu Leu Glu Leu Val Thr Ser Ala Lys
         160                 165                 170

 gct ctg aac gac act cag aaa ttg gcc tgc ctc atc ggt gta gag ggt      637
 Ala Leu Asn Asp Thr Gln Lys Leu Ala Cys Leu Ile Gly Val Glu Gly
     175                 180                 185

 ggc cac tcg ctg gac aat agc ctc tcc atc tta cgt acc ttc tac atg      685
 Gly His Ser Leu Asp Asn Ser Leu Ser Ile Leu Arg Thr Phe Tyr Met
 190                 195                 200                 205

 ctg gga gtg cgc tac ctg acg ctc acc cac acc tgc aac aca ccc tgg      733
 Leu Gly Val Arg Tyr Leu Thr Leu Thr His Thr Cys Asn Thr Pro Trp
                 210                 215                 220

 gca gag agc tcc gct aag ggc gtc cac tcc ttc tac aac aac atc agc      781
 Ala Glu Ser Ser Ala Lys Gly Val His Ser Phe Tyr Asn Asn Ile Ser
             225                 230                 235

 ggg ctg act gac ttt ggt gag aag gtg gtg gca gaa atg aac cgc ctg      829
 Gly Leu Thr Asp Phe Gly Glu Lys Val Val Ala Glu Met Asn Arg Leu
         240                 245                 250

 ggc atg atg gta gac tta tcc cat gtc tca gat gct gtg gca cgg cgg      877
 Gly Met Met Val Asp Leu Ser His Val Ser Asp Ala Val Ala Arg Arg
     255                 260                 265

 gcc ctg gaa gtg tca cag gca cct gtg atc ttc tcc cac tcg gct gcc      925
 Ala Leu Glu Val Ser Gln Ala Pro Val Ile Phe Ser His Ser Ala Ala
 270                 275                 280                 285

 cgg ggt gtg tgc aac agt gct cgg aat gtt cct gat gac atc ctg cag      973
 Arg Gly Val Cys Asn Ser Ala Arg Asn Val Pro Asp Asp Ile Leu Gln
                 290                 295                 300

 ctt ctg aag aag aac ggt ggc gtc gtg atg gtg tct ttg tcc atg gga     1021
 Leu Leu Lys Lys Asn Gly Gly Val Val Met Val Ser Leu Ser Met Gly
             305                 310                 315

 gta ata cag tgc aac cca tca gcc aat gtg tcc act gtg gca gat cac     1069
 Val Ile Gln Cys Asn Pro Ser Ala Asn Val Ser Thr Val Ala Asp His
         320                 325                 330

 ttc gac cac atc aag gct gtc att gga tcc aag ttc atc ggg att ggt     1117
 Phe Asp His Ile Lys Ala Val Ile Gly Ser Lys Phe Ile Gly Ile Gly
     335                 340                 345

 gga gat tat gat ggg gcc ggc aag tac agg aag aaa aca aag tgc aaa     1165
 Gly Asp Tyr Asp Gly Ala Gly Lys Tyr Arg Lys Lys Thr Lys Cys Lys
 350                 355                 360                 365

 gcc cct tgg agg aca agt tcc cgg atg agc agc tga gcag ttcctgccac     1215
 Ala Pro Trp Arg Thr Ser Ser Arg Met Ser Ser 
                 370                 375

 tccgacctct cacgtctgcg tcagagacag agtctgactt caggccagga actcactgag   1275

 attcccatac actggacagc caagttacca gccaagtggt cagtctcaga gtcctccccc   1335

 cacatggccc cagtccttgc agttgtggcc accttcccag tccttattct gtggctctga   1395

 tgacccagtt agtcctgcca gatgtcactg tagcaagcca cagacacccc acaaagttcc   1455

 cctgttgtgc aggcacaaat atttcctgaa ataaatgttt tggacataga aacagaaaaa   1515

 aaaaaaa                                                             1522




      <210> 348
      <211> 2131
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (236)..(1741)

      <400> 348
 ggaacgagga ggtggagaat tgagagcacg atgcatacac aggtgtttct gagtagtaat     60

 tagatcgctg tgaaggaaaa agcacacctt tgagttttca cctgtgaaca ctatagcgct    120

 gagagagaca gtctgaaagc agaggaagac atcgatcagt aacaccaaga gacaccaaag    180

 ttgaaagttt tgttttcttt ccctctgttt tatttttccc ccgtgtgtcc ctact atg     238
                                                              Met
                                                                1

 gtc aga aag cct gtt gtg tcc acc atc tcc aaa gga ggt tac ctg cag      286
 Val Arg Lys Pro Val Val Ser Thr Ile Ser Lys Gly Gly Tyr Leu Gln
               5                  10                  15

 gga aat gtt aac ggg agg ctg cct tcc ctg ggc aac aag gag cca cct      334
 Gly Asn Val Asn Gly Arg Leu Pro Ser Leu Gly Asn Lys Glu Pro Pro
          20                  25                  30

 ggg cag gag aaa gtg cag ctg aag agg aaa gtc act tta ctg agg gga      382
 Gly Gln Glu Lys Val Gln Leu Lys Arg Lys Val Thr Leu Leu Arg Gly
      35                  40                  45

 gtc tcc att atc att ggc acc atc att gga gca gga atc ttc atc tct      430
 Val Ser Ile Ile Ile Gly Thr Ile Ile Gly Ala Gly Ile Phe Ile Ser
  50                  55                  60                  65

 cct aag ggc gtg ctc cag aac acg ggc agc gtg ggc atg tct ctg acc      478
 Pro Lys Gly Val Leu Gln Asn Thr Gly Ser Val Gly Met Ser Leu Thr
                  70                  75                  80

 atc tgg acg gtg tgt ggg gtc ctg tca cta ttt gga gct ttg tct tat      526
 Ile Trp Thr Val Cys Gly Val Leu Ser Leu Phe Gly Ala Leu Ser Tyr
              85                  90                  95

 gct gaa ttg gga aca act ata aag aaa tct gga ggt cat tac aca tat      574
 Ala Glu Leu Gly Thr Thr Ile Lys Lys Ser Gly Gly His Tyr Thr Tyr
         100                 105                 110

 att ttg gaa gtc ttt ggt cca tta cca gct ttt gta cga gtc tgg gtg      622
 Ile Leu Glu Val Phe Gly Pro Leu Pro Ala Phe Val Arg Val Trp Val
     115                 120                 125

 gaa ctc ctc ata ata cgc cct gca gct act gct gtg ata tcc ctg gca      670
 Glu Leu Leu Ile Ile Arg Pro Ala Ala Thr Ala Val Ile Ser Leu Ala
 130                 135                 140                 145

 ttt gga cgc tac att ctg gaa cca ttt ttt att caa tgt gaa atc cct      718
 Phe Gly Arg Tyr Ile Leu Glu Pro Phe Phe Ile Gln Cys Glu Ile Pro
                 150                 155                 160

 gaa ctt gcg atc aag ctc att aca gct gtg ggc ata act gta gtg atg      766
 Glu Leu Ala Ile Lys Leu Ile Thr Ala Val Gly Ile Thr Val Val Met
             165                 170                 175

 gtc cta aat agc atg agt gtc agc tgg agc gcc cgg atc cag att ttc      814
 Val Leu Asn Ser Met Ser Val Ser Trp Ser Ala Arg Ile Gln Ile Phe
         180                 185                 190

 tta acc ttt tgc aag ctc aca gca att ctg ata att ata gtc cct gga      862
 Leu Thr Phe Cys Lys Leu Thr Ala Ile Leu Ile Ile Ile Val Pro Gly
     195                 200                 205

 gtt atg cag cta att aaa ggt caa acg cag aac ttt aaa gac gcg ttt      910
 Val Met Gln Leu Ile Lys Gly Gln Thr Gln Asn Phe Lys Asp Ala Phe
 210                 215                 220                 225

 tca gga aga gat tca agt att acg cgg ttg cca ctg gct ttt tat tat      958
 Ser Gly Arg Asp Ser Ser Ile Thr Arg Leu Pro Leu Ala Phe Tyr Tyr
                 230                 235                 240

 gga atg tat gca tat gct ggc tgg ttt tac ctc aac ttt gtt act gaa     1006
 Gly Met Tyr Ala Tyr Ala Gly Trp Phe Tyr Leu Asn Phe Val Thr Glu
             245                 250                 255

 gaa gta gaa aac cct gaa aaa acc att ccc ctt gca ata tgt ata tcc     1054
 Glu Val Glu Asn Pro Glu Lys Thr Ile Pro Leu Ala Ile Cys Ile Ser
         260                 265                 270

 atg gcc att gtc acc att ggc tat gtg ctg aca aat gtg gcc tac ttt     1102
 Met Ala Ile Val Thr Ile Gly Tyr Val Leu Thr Asn Val Ala Tyr Phe
     275                 280                 285

 acg acc att aat gct gag gag ctg ctg ctt tca aat gca gtg gca gtg     1150
 Thr Thr Ile Asn Ala Glu Glu Leu Leu Leu Ser Asn Ala Val Ala Val
 290                 295                 300                 305

 acc ttt tct gag cgg cta ctg gga aat ttc tca tta gca gtt ccg atc     1198
 Thr Phe Ser Glu Arg Leu Leu Gly Asn Phe Ser Leu Ala Val Pro Ile
                 310                 315                 320

 ttt gtt gcc ctc tcc tgc ttt ggc tcc atg aac ggt ggt gtg ttt gct     1246
 Phe Val Ala Leu Ser Cys Phe Gly Ser Met Asn Gly Gly Val Phe Ala
             325                 330                 335

 gtc tcc agg tta ttc tat gtt gcg tct cga gag ggt cac ctt cca gaa     1294
 Val Ser Arg Leu Phe Tyr Val Ala Ser Arg Glu Gly His Leu Pro Glu
         340                 345                 350

 atc ctc tcc atg att cat gtc cgc aag cac act cct cta cca gct gtt     1342
 Ile Leu Ser Met Ile His Val Arg Lys His Thr Pro Leu Pro Ala Val
     355                 360                 365

 att gtt ttg cac cct ttg aca atg ata atg ctc ttc tct gga gac ctc     1390
 Ile Val Leu His Pro Leu Thr Met Ile Met Leu Phe Ser Gly Asp Leu
 370                 375                 380                 385

 gac agt ctt ttg aat ttc ctc agt ttt gcc agg tgg ctt ttt att ggg     1438
 Asp Ser Leu Leu Asn Phe Leu Ser Phe Ala Arg Trp Leu Phe Ile Gly
                 390                 395                 400

 ctg gca gtt gct ggg ctg att tat ctt cga tac aaa tgc cca gat atg     1486
 Leu Ala Val Ala Gly Leu Ile Tyr Leu Arg Tyr Lys Cys Pro Asp Met
             405                 410                 415

 cat cgt cct ttc aag gtg cca ctg ttc atc cca gct ttg ttt tcc ttc     1534
 His Arg Pro Phe Lys Val Pro Leu Phe Ile Pro Ala Leu Phe Ser Phe
         420                 425                 430

 aca tgc ctc ttc atg gtt gcc ctt tcc ctc tat tcg gac cca ttt agt     1582
 Thr Cys Leu Phe Met Val Ala Leu Ser Leu Tyr Ser Asp Pro Phe Ser
     435                 440                 445

 aca ggg att ggc ttc gtc atc act ctg act gga gtc cct gcg tat tat     1630
 Thr Gly Ile Gly Phe Val Ile Thr Leu Thr Gly Val Pro Ala Tyr Tyr
 450                 455                 460                 465

 ctc ttt att ata tgg gac aag aaa ccc agg tgg ttt aga ata atg tca     1678
 Leu Phe Ile Ile Trp Asp Lys Lys Pro Arg Trp Phe Arg Ile Met Ser
                 470                 475                 480

 gag aaa ata acc aga aca tta caa ata ata ctg gaa gtt gta cca gaa     1726
 Glu Lys Ile Thr Arg Thr Leu Gln Ile Ile Leu Glu Val Val Pro Glu
             485                 490                 495

 gaa gat aag tta tga actaatggac ttgagatctt ggcaatctgc ccaaggggag     1781
 Glu Asp Lys Leu 
         500

 acacaaaata gggattttta cttcattttc tgaaagtcta gagaattaca actttggtga   1841

 taaacaaaag gagtcagtta tttttattca tatattttag catattcgaa ctaatttcta   1901

 agaaatttag ttataactct atgtagttat agaaagtgaa tatgcagtta ttctatgagt   1961

 cgcacaattc ttgagtctct gatacctacc tattggggtt aggagaaaag actagacaat   2021

 tactatgtgg tcattctcta caacatatgt tagcacggca aagaaccttc aaattgaaga   2081

 ctgagatttt tctgtatata tgggttttgg aaagatggtt ttacacacta              2131




      <210> 349
      <211> 3652
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (310)..(3249)

      <400> 349
 acggctaggt acgaggcctg gtgttagcag agttgagtcc actccgcacc ccaccctctg     60

 tctggtacag cttaccaaac caaagtgccc aaagccgtga catcccggcc ggcggctcgc    120

 aggcccccgc cctccgcacg tcacggccgc cgggtgcagt gccccctagg ggcccctggg    180

 acgaggagga agcgccaggt ccttcccgcc gccgccgccg ccgccgccgc cgcctgctcc    240

 cctggcacgc gccccgccgc cctcggcagc cgcagctccg tgtcccctga gaaccagccg    300

 tcccgcgcc    atg ggc acg cgt ctg ccg ctc gtc ctg cgc cag ctc cgc     348
              Met Gly Thr Arg Leu Pro Leu Val Leu Arg Gln Leu Arg
                1               5                  10

 cgc ccg ccc cag ccc ccg ggc cct ccg cgc cgc ctc cgt gtg ccc tgt      396
 Arg Pro Pro Gln Pro Pro Gly Pro Pro Arg Arg Leu Arg Val Pro Cys
      15                  20                  25

 cgc gct agc agc ggc ggc ggc gga ggc ggc ggc ggt ggc cgg gag ggc      444
 Arg Ala Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Glu Gly
  30                  35                  40                  45

 ctg ctt gga cag cgg cgg ccg cag gat ggc cag gcc cgg agc agc tgc      492
 Leu Leu Gly Gln Arg Arg Pro Gln Asp Gly Gln Ala Arg Ser Ser Cys
                  50                  55                  60

 agc ccc ggc ggc cga acg ccc gcg gcg cgg gac tcc atc gtc aga gaa      540
 Ser Pro Gly Gly Arg Thr Pro Ala Ala Arg Asp Ser Ile Val Arg Glu
              65                  70                  75

 gtc att cag aat tca aaa gaa gtt cta agt tta ttg caa gaa aaa aac      588
 Val Ile Gln Asn Ser Lys Glu Val Leu Ser Leu Leu Gln Glu Lys Asn
          80                  85                  90

 cct gcc ttc aag ccg gtt ctt gca att atc cag gca ggt gac gac aac      636
 Pro Ala Phe Lys Pro Val Leu Ala Ile Ile Gln Ala Gly Asp Asp Asn
      95                 100                 105

 ttg atg cag gaa atc aac cag aat ttg gct gag gag gct ggt ctg aac      684
 Leu Met Gln Glu Ile Asn Gln Asn Leu Ala Glu Glu Ala Gly Leu Asn
 110                 115                 120                 125

 atc act cac att tgc ctc cct cca gat agc agt gaa gcc gag att ata      732
 Ile Thr His Ile Cys Leu Pro Pro Asp Ser Ser Glu Ala Glu Ile Ile
                 130                 135                 140

 gat gaa atc tta aag atc aat gaa gat acc aga gta cat ggc ctt gcc      780
 Asp Glu Ile Leu Lys Ile Asn Glu Asp Thr Arg Val His Gly Leu Ala
             145                 150                 155

 ctt cag atc tct gag aac ttg ttt agc aac aaa gtc ctc aat gcc ttg      828
 Leu Gln Ile Ser Glu Asn Leu Phe Ser Asn Lys Val Leu Asn Ala Leu
         160                 165                 170

 aaa cca gaa aaa gat gtg gat gga gta aca gac ata aac ctg ggg aag      876
 Lys Pro Glu Lys Asp Val Asp Gly Val Thr Asp Ile Asn Leu Gly Lys
     175                 180                 185

 ctg gtg cga ggg gat gcc cat gaa tgt ttt gtt tca cct gtt gcc aaa      924
 Leu Val Arg Gly Asp Ala His Glu Cys Phe Val Ser Pro Val Ala Lys
 190                 195                 200                 205

 gct gta att gaa ctt ctt gaa aaa tca gta ggt gtc aac cta gat gga      972
 Ala Val Ile Glu Leu Leu Glu Lys Ser Val Gly Val Asn Leu Asp Gly
                 210                 215                 220

 aag aag att ttg gta gtg ggg gcc cat ggg tct ttg gaa gct gct cta     1020
 Lys Lys Ile Leu Val Val Gly Ala His Gly Ser Leu Glu Ala Ala Leu
             225                 230                 235

 caa tgc ctg ttc cag aga aaa ggg tcc atg aca atg agc atc cag tgg     1068
 Gln Cys Leu Phe Gln Arg Lys Gly Ser Met Thr Met Ser Ile Gln Trp
         240                 245                 250

 aaa aca cgc cag ctt caa agc aag ctt cac gag gct gac att gtg gtc     1116
 Lys Thr Arg Gln Leu Gln Ser Lys Leu His Glu Ala Asp Ile Val Val
     255                 260                 265

 cta ggc tca cct aag cca gaa gag att ccc ctt act tgg ata caa cca     1164
 Leu Gly Ser Pro Lys Pro Glu Glu Ile Pro Leu Thr Trp Ile Gln Pro
 270                 275                 280                 285

 gga act act gtt ctc aac tgc tcc cat gac ttc ctg tca ggg aag gtt     1212
 Gly Thr Thr Val Leu Asn Cys Ser His Asp Phe Leu Ser Gly Lys Val
                 290                 295                 300

 ggg tgt ggc tct cca aga ata cat ttt ggt gga ctc att gag gaa gat     1260
 Gly Cys Gly Ser Pro Arg Ile His Phe Gly Gly Leu Ile Glu Glu Asp
             305                 310                 315

 gat gtg att ctc ctt gct gca gct ctg cga att cag aac atg gtc agt     1308
 Asp Val Ile Leu Leu Ala Ala Ala Leu Arg Ile Gln Asn Met Val Ser
         320                 325                 330

 agt gga agg aga tgg ctt cgt gaa cag cag cac agg cgg tgg aga ctt     1356
 Ser Gly Arg Arg Trp Leu Arg Glu Gln Gln His Arg Arg Trp Arg Leu
     335                 340                 345

 cac tgc ttg aaa ctt cag cct ctc tcc cct gtg cca agt gac att gag     1404
 His Cys Leu Lys Leu Gln Pro Leu Ser Pro Val Pro Ser Asp Ile Glu
 350                 355                 360                 365

 att tca aga gga caa act cca aaa gct gtg gat gtc ctt gcc aag gag     1452
 Ile Ser Arg Gly Gln Thr Pro Lys Ala Val Asp Val Leu Ala Lys Glu
                 370                 375                 380

 att gga ttg ctt gca gat gaa att gaa atc tat ggc aaa agc aaa gcc     1500
 Ile Gly Leu Leu Ala Asp Glu Ile Glu Ile Tyr Gly Lys Ser Lys Ala
             385                 390                 395

 aaa gta cgt ttg tcc gtg cta gaa agg tta aag gat caa gca gat gga     1548
 Lys Val Arg Leu Ser Val Leu Glu Arg Leu Lys Asp Gln Ala Asp Gly
         400                 405                 410

 aaa tac gtc tta gtt gct ggg atc aca ccc acc cct ctt gga gaa ggg     1596
 Lys Tyr Val Leu Val Ala Gly Ile Thr Pro Thr Pro Leu Gly Glu Gly
     415                 420                 425

 aag agc aca gtc acc atc ggg ctt gtg cag gct ctg acc gca cac ctg     1644
 Lys Ser Thr Val Thr Ile Gly Leu Val Gln Ala Leu Thr Ala His Leu
 430                 435                 440                 445

 aat gtc aac tcc ttt gcc tgc ttg agg cag cct tcc caa gga ccg acg     1692
 Asn Val Asn Ser Phe Ala Cys Leu Arg Gln Pro Ser Gln Gly Pro Thr
                 450                 455                 460

 ttt gga gtg aaa gga gga gcc gcg ggt ggt gga tat gcc cag gtc atc     1740
 Phe Gly Val Lys Gly Gly Ala Ala Gly Gly Gly Tyr Ala Gln Val Ile
             465                 470                 475

 ccc atg gag gag ttc aac ctt cac ttg act gga gac atc cac gcc atc     1788
 Pro Met Glu Glu Phe Asn Leu His Leu Thr Gly Asp Ile His Ala Ile
         480                 485                 490

 acc gct gcc aat aac ttg ctg gct gcc gcc atc gac acg agg att ctt     1836
 Thr Ala Ala Asn Asn Leu Leu Ala Ala Ala Ile Asp Thr Arg Ile Leu
     495                 500                 505

 cat gaa aac acg caa aca gat aag gct ctg tat aat cgg ctg gtt cct     1884
 His Glu Asn Thr Gln Thr Asp Lys Ala Leu Tyr Asn Arg Leu Val Pro
 510                 515                 520                 525

 tta gtg aat ggt gtc aga gaa ttt tca gaa att cag ctt gct cgg cta     1932
 Leu Val Asn Gly Val Arg Glu Phe Ser Glu Ile Gln Leu Ala Arg Leu
                 530                 535                 540

 aaa aaa ctg gga ata aat aag act gat ccg agc aca ctg aca gaa gag     1980
 Lys Lys Leu Gly Ile Asn Lys Thr Asp Pro Ser Thr Leu Thr Glu Glu
             545                 550                 555

 gaa gtg agt aaa ttt gcc cgt ctc gac atc gac cca tct acc atc acg     2028
 Glu Val Ser Lys Phe Ala Arg Leu Asp Ile Asp Pro Ser Thr Ile Thr
         560                 565                 570

 tgg cag aga gta ttg gat aca aat gac cga ttt cta cga aaa ata acc     2076
 Trp Gln Arg Val Leu Asp Thr Asn Asp Arg Phe Leu Arg Lys Ile Thr
     575                 580                 585

 atc ggg cag gga aac aca gag aag ggc cat tac cgg cag gcg cag ttt     2124
 Ile Gly Gln Gly Asn Thr Glu Lys Gly His Tyr Arg Gln Ala Gln Phe
 590                 595                 600                 605

 gac atc gca gtg gcc agc gag atc atg gcg gtg ctg gcc ctg acg gac     2172
 Asp Ile Ala Val Ala Ser Glu Ile Met Ala Val Leu Ala Leu Thr Asp
                 610                 615                 620

 agc ctc gca gac atg aag gca cgg ctg gga agg atg gtg gtg gcc agt     2220
 Ser Leu Ala Asp Met Lys Ala Arg Leu Gly Arg Met Val Val Ala Ser
             625                 630                 635

 gac aaa agc ggg cag cct gtg aca gca gat gat ttg ggg gtg aca ggt     2268
 Asp Lys Ser Gly Gln Pro Val Thr Ala Asp Asp Leu Gly Val Thr Gly
         640                 645                 650

 gct ttg aca gtt ttg atg aaa gat gca ata aaa cca aac ctg atg cag     2316
 Ala Leu Thr Val Leu Met Lys Asp Ala Ile Lys Pro Asn Leu Met Gln
     655                 660                 665

 acc ctg gaa ggg aca cct gtg ttc gtg cat gcg ggc cct ttt gct aac     2364
 Thr Leu Glu Gly Thr Pro Val Phe Val His Ala Gly Pro Phe Ala Asn
 670                 675                 680                 685

 att gct cac ggc aac tct tca gtg ttg gct gat aaa att gcc ctg aaa     2412
 Ile Ala His Gly Asn Ser Ser Val Leu Ala Asp Lys Ile Ala Leu Lys
                 690                 695                 700

 ctg gtt ggt gaa gaa gga ttt gta gtg acc gaa gct ggc ttt ggt gct     2460
 Leu Val Gly Glu Glu Gly Phe Val Val Thr Glu Ala Gly Phe Gly Ala
             705                 710                 715

 gac atc gga atg gag aaa ttc ttc aac atc aag tgc cga gct tcc ggc     2508
 Asp Ile Gly Met Glu Lys Phe Phe Asn Ile Lys Cys Arg Ala Ser Gly
         720                 725                 730

 ttg gtg ccc aac gtg gtt gtg tta gtg gca acg gtg cga gct ctg aag     2556
 Leu Val Pro Asn Val Val Val Leu Val Ala Thr Val Arg Ala Leu Lys
     735                 740                 745

 atg cat gga ggc ggg cca agt gta acg gct ggt gtt cct ctt aag aaa     2604
 Met His Gly Gly Gly Pro Ser Val Thr Ala Gly Val Pro Leu Lys Lys
 750                 755                 760                 765

 gaa tat aca gag gag aac atc cag ctg gtg gca gac ggc tgc tgt aac     2652
 Glu Tyr Thr Glu Glu Asn Ile Gln Leu Val Ala Asp Gly Cys Cys Asn
                 770                 775                 780

 ctc cag aag caa att cag atc act cag ctc ttt ggg gtt ccc gtt gtg     2700
 Leu Gln Lys Gln Ile Gln Ile Thr Gln Leu Phe Gly Val Pro Val Val
             785                 790                 795

 gtg gct ctg aat gtc ttc aag acc gac acc cgc gct gag att gac ttg     2748
 Val Ala Leu Asn Val Phe Lys Thr Asp Thr Arg Ala Glu Ile Asp Leu
         800                 805                 810

 gtg tgt gag ctt gca aag cgg gct ggt gcc ttt gat gca gtc ccc tgc     2796
 Val Cys Glu Leu Ala Lys Arg Ala Gly Ala Phe Asp Ala Val Pro Cys
     815                 820                 825

 tat cac tgg tcg gtt ggt gga aaa gga tcg gtg gac ttg gct cgg gct     2844
 Tyr His Trp Ser Val Gly Gly Lys Gly Ser Val Asp Leu Ala Arg Ala
 830                 835                 840                 845

 gtg aga gag gct gcg agt aaa aga agc cga ttc cag ttc ctg tat gat     2892
 Val Arg Glu Ala Ala Ser Lys Arg Ser Arg Phe Gln Phe Leu Tyr Asp
                 850                 855                 860

 gtt cag gtt cca att gtg gac aag ata agg acc att gct cag gct gtc     2940
 Val Gln Val Pro Ile Val Asp Lys Ile Arg Thr Ile Ala Gln Ala Val
             865                 870                 875

 tat gga gcc aaa gat att gaa ctc tct cct gag gca caa gcc aaa ata     2988
 Tyr Gly Ala Lys Asp Ile Glu Leu Ser Pro Glu Ala Gln Ala Lys Ile
         880                 885                 890

 gat cgt tac act caa cag ggt ttt gga aat ttg ccc atc tgc atg gca     3036
 Asp Arg Tyr Thr Gln Gln Gly Phe Gly Asn Leu Pro Ile Cys Met Ala
     895                 900                 905

 aag acc cac ctt tct cta tct cac caa cct gac aaa aaa ggt gtg cca     3084
 Lys Thr His Leu Ser Leu Ser His Gln Pro Asp Lys Lys Gly Val Pro
 910                 915                 920                 925

 agg gac ttc atc tta cct atc agt gac gtc cgg gcc agc ata ggc gct     3132
 Arg Asp Phe Ile Leu Pro Ile Ser Asp Val Arg Ala Ser Ile Gly Ala
                 930                 935                 940

 ggg ttc att tac cct ttg gtc gga acg atg agc acc atg cca gga ctg     3180
 Gly Phe Ile Tyr Pro Leu Val Gly Thr Met Ser Thr Met Pro Gly Leu
             945                 950                 955

 ccc acc cgg ccc tgc ttt tat gac ata gat ctt gat acc gaa aca gaa     3228
 Pro Thr Arg Pro Cys Phe Tyr Asp Ile Asp Leu Asp Thr Glu Thr Glu
         960                 965                 970

 caa gtt aaa ggc ttg ttc taa gt ggacaaggct ctcacaggac ccgatgcaga     3281
 Gln Val Lys Gly Leu Phe 
     975

 ctcctgaaac agactactct ttgccttttt gctgcagttg gagaagaaac tgaatttgaa   3341

 aaatgtctgt tatgcaatgc tggagacatg gtgaaatagg ccaaagattt cttcttcgtt   3401

 caagatgaat tctgttcaca gtggagtatg gtgttcggca aaaggacctc caccaagact   3461

 gaaagaaact aatttatttc tgtttctgtg gagtttccat tatttctact gcttacactt   3521

 tagaatgttt attttatggg gactaaggga ttaggagtgt gaactaaaag gtaacatttt   3581

 ccactctcaa gttttctact ttgtctttga actgaaaata aacatggatc tagaaaacca   3641

 aaaaaaaaaa a                                                        3652




      <210> 350
      <211> 5869
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (462)..(4193)

      <400> 350
 atttggccct cgaggccaag aattcggcac gagaaggaag tagcctacgt ccacgcctac     60

 aactgaagtc tcttgacaaa cacctcaccc ctgcctccgg gatgaaaggg ggtaacctag    120

 acctgaatgg gcttgaccat ctcacaactg ctcgcgtgac gaccgcattc gtggcaggta    180

 agaagattgc tgtatcaact caagaaagca gtaacttcac tgtctttgta ttttgaattg    240

 caacaacaac tttgatatca acaatgaagc aatgatatct aagaacaaaa gagtatttgc    300

 caacagtcat cataatatca agtgattgta taagcagaaa caagctgtca cagacctgtg    360

 cgtcagctaa tatatggaga atgctttctt ctgatactat ttacttagag gcagttttaa    420

 tataaatcat ttcaattata tctacatcaa ataaaataaa a    atg agt gaa gcc     473
                                                  Met Ser Glu Ala
                                                    1

 ccc aga ttc ttc gtt gga cca gaa gat aca gaa ata aat cct gga aat      521
 Pro Arg Phe Phe Val Gly Pro Glu Asp Thr Glu Ile Asn Pro Gly Asn
   5                  10                  15                  20

 tat cga cat ttc ttc cac cat gca gat gaa gac gat gag gag gaa gat      569
 Tyr Arg His Phe Phe His His Ala Asp Glu Asp Asp Glu Glu Glu Asp
                  25                  30                  35

 gat tct cca cca gaa agg cag att gtg gtt gga ata tgt tcc atg gca      617
 Asp Ser Pro Pro Glu Arg Gln Ile Val Val Gly Ile Cys Ser Met Ala
              40                  45                  50

 aag aaa tcc aaa tcc aaa cca atg aag gaa att ctt gaa cgg atc tcc      665
 Lys Lys Ser Lys Ser Lys Pro Met Lys Glu Ile Leu Glu Arg Ile Ser
          55                  60                  65

 tta ttt aaa tat atc aca gta gta gta ttt gaa gag gag gtt att ttg      713
 Leu Phe Lys Tyr Ile Thr Val Val Val Phe Glu Glu Glu Val Ile Leu
      70                  75                  80

 aat gaa cca gtg gaa aac tgg cct tta tgt gat tgt ctt att tct ttc      761
 Asn Glu Pro Val Glu Asn Trp Pro Leu Cys Asp Cys Leu Ile Ser Phe
  85                  90                  95                 100

 cat tct aaa gga ttt cca ctg gac aaa gcg gtt gcc tat gca aaa ctc      809
 His Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ala Lys Leu
                 105                 110                 115

 agg aat cca ttt gta atc aat gac ttg aat atg cag tat ctc ata caa      857
 Arg Asn Pro Phe Val Ile Asn Asp Leu Asn Met Gln Tyr Leu Ile Gln
             120                 125                 130

 gat agg aga gaa gta tat agt att ctt caa gct gaa ggt att tta ctt      905
 Asp Arg Arg Glu Val Tyr Ser Ile Leu Gln Ala Glu Gly Ile Leu Leu
         135                 140                 145

 cct cgt tat gct att ttg aac cgt gac cca aat aat ccc aaa gaa tgt      953
 Pro Arg Tyr Ala Ile Leu Asn Arg Asp Pro Asn Asn Pro Lys Glu Cys
     150                 155                 160

 aat ctg att gaa ggg gaa gat cat gta gaa gta aat ggg gaa gtt ttt     1001
 Asn Leu Ile Glu Gly Glu Asp His Val Glu Val Asn Gly Glu Val Phe
 165                 170                 175                 180

 caa aag cca ttt gta gaa aag cca gtc agt gca gaa gat cac aat gtt     1049
 Gln Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn Val
                 185                 190                 195

 tac att tat tac cca act tct gct ggt ggt gga agt caa aga ctc ttt     1097
 Tyr Ile Tyr Tyr Pro Thr Ser Ala Gly Gly Gly Ser Gln Arg Leu Phe
             200                 205                 210

 aga aag att ggc agt aga agt agt gtt tat tct cca gaa agc aat gta     1145
 Arg Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro Glu Ser Asn Val
         215                 220                 225

 cga aaa aca ggc tca tat ata tat gaa gag ttt atg ccc aca gat ggt     1193
 Arg Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met Pro Thr Asp Gly
     230                 235                 240

 act gat gtt aag gtt tat aca gtg ggt cca gat tat gcc cat gct gaa     1241
 Thr Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr Ala His Ala Glu
 245                 250                 255                 260

 gct cga aaa tct cca gca ctt gat ggc aag gtg gaa cga gac agt gaa     1289
 Ala Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu Arg Asp Ser Glu
                 265                 270                 275

 gga aaa gaa gta aga tac cct gtt att ctc aat gca cga gag aaa tta     1337
 Gly Lys Glu Val Arg Tyr Pro Val Ile Leu Asn Ala Arg Glu Lys Leu
             280                 285                 290

 att gct tgg aaa gtc tgc ctt gct ttt aag caa aca gtt tgt ggc ttt     1385
 Ile Ala Trp Lys Val Cys Leu Ala Phe Lys Gln Thr Val Cys Gly Phe
         295                 300                 305

 gat ttg tta cgg gcc aat gga cag tcc tat gtc tgt gat gtc aat ggc     1433
 Asp Leu Leu Arg Ala Asn Gly Gln Ser Tyr Val Cys Asp Val Asn Gly
     310                 315                 320

 ttc agt ttt gtg aaa aat tcc atg aag tat tat gat gac tgt gca aaa     1481
 Phe Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp Asp Cys Ala Lys
 325                 330                 335                 340

 ata ctt gga aat att gta atg cga gaa ctt gct cca caa ttt cat att     1529
 Ile Leu Gly Asn Ile Val Met Arg Glu Leu Ala Pro Gln Phe His Ile
                 345                 350                 355

 cca tgg tca ata ccc tta gaa gct gaa gat atc cca att gta cca act     1577
 Pro Trp Ser Ile Pro Leu Glu Ala Glu Asp Ile Pro Ile Val Pro Thr
             360                 365                 370

 aca tct gga act atg atg gaa ctt aga tgt gtc ata gct gtt ata cgt     1625
 Thr Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile Ala Val Ile Arg
         375                 380                 385

 cat ggg gat cga aca cca aaa aaa aaa atg aaa atg gaa gtg aga cat     1673
 His Gly Asp Arg Thr Pro Lys Lys Lys Met Lys Met Glu Val Arg His
     390                 395                 400

 cag aaa ttt ttt gat ctt ttt gaa aag tgt gat gga tat aaa tca ggg     1721
 Gln Lys Phe Phe Asp Leu Phe Glu Lys Cys Asp Gly Tyr Lys Ser Gly
 405                 410                 415                 420

 aaa tta aaa ctc aaa aaa cca aaa cag tta cag gaa gtg cta gat att     1769
 Lys Leu Lys Leu Lys Lys Pro Lys Gln Leu Gln Glu Val Leu Asp Ile
                 425                 430                 435

 gca cga cag ctt ctt atg gag cta ggg caa aat aat gat tct gaa att     1817
 Ala Arg Gln Leu Leu Met Glu Leu Gly Gln Asn Asn Asp Ser Glu Ile
             440                 445                 450

 gaa gaa aac aag cca aaa ctt gaa caa ctt aag act gta tta gag atg     1865
 Glu Glu Asn Lys Pro Lys Leu Glu Gln Leu Lys Thr Val Leu Glu Met
         455                 460                 465

 tat ggt cat ttt tct gga ata aat cgt aag gtt cag ttg acc tat ctc     1913
 Tyr Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln Leu Thr Tyr Leu
     470                 475                 480

 cct cat ggt tgt cct aaa aca tct agt gaa gag gag gac agc cga aga     1961
 Pro His Gly Cys Pro Lys Thr Ser Ser Glu Glu Glu Asp Ser Arg Arg
 485                 490                 495                 500

 gaa gaa cca tct tta ctt ttg gtt cta aaa tgg gga ggt gaa tta act     2009
 Glu Glu Pro Ser Leu Leu Leu Val Leu Lys Trp Gly Gly Glu Leu Thr
                 505                 510                 515

 cct gca ggc agg gtc cag gct gaa gaa ctt gga aga gcc ttc agg tgt     2057
 Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg Ala Phe Arg Cys
             520                 525                 530

 atg tat cct gga ggt caa gga gat tat gca gga ttt cct ggt tgt ggt     2105
 Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe Pro Gly Cys Gly
         535                 540                 545

 tta ctt aga tta cat agc acc tac aga cat gac ctc aaa ata tat gcc     2153
 Leu Leu Arg Leu His Ser Thr Tyr Arg His Asp Leu Lys Ile Tyr Ala
     550                 555                 560

 tct gat gaa gga cga gtc cag atg act gca gct gct ttt gca aag ggg     2201
 Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala Phe Ala Lys Gly
 565                 570                 575                 580

 ctt tta gct ttg gaa gga gag ctt aca ccc att ctt gtt caa atg gtg     2249
 Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu Val Gln Met Val
                 585                 590                 595

 aaa agt gca aat atg aac ggt ctt ttg gat agt gat agt gac tct ctg     2297
 Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp Ser Asp Ser Leu
             600                 605                 610

 agc agt tgt cag caa cgt gtg aag gca agg ctt cat gaa ata ctt cag     2345
 Ser Ser Cys Gln Gln Arg Val Lys Ala Arg Leu His Glu Ile Leu Gln
         615                 620                 625

 aaa gac aga gat ttt act gct gaa gat tat gaa aag ctt act cca tct     2393
 Lys Asp Arg Asp Phe Thr Ala Glu Asp Tyr Glu Lys Leu Thr Pro Ser
     630                 635                 640

 gga agc att tct ctt atc aaa tca atg cat tta att aaa aac cct gtg     2441
 Gly Ser Ile Ser Leu Ile Lys Ser Met His Leu Ile Lys Asn Pro Val
 645                 650                 655                 660

 aag acc tgt gat aaa gtt tat tcc tta att cag agt ttg act tct caa     2489
 Lys Thr Cys Asp Lys Val Tyr Ser Leu Ile Gln Ser Leu Thr Ser Gln
                 665                 670                 675

 atc aga cat cga atg gaa gat cct aaa tca tca gat att cag ctt tac     2537
 Ile Arg His Arg Met Glu Asp Pro Lys Ser Ser Asp Ile Gln Leu Tyr
             680                 685                 690

 cat agt gaa aca ttg gag ctt atg cta cgt aga tgg tcc aag tta gag     2585
 His Ser Glu Thr Leu Glu Leu Met Leu Arg Arg Trp Ser Lys Leu Glu
         695                 700                 705

 aaa gac ttt aaa aca aag aat gga aga tat gat att agt aaa atc cct     2633
 Lys Asp Phe Lys Thr Lys Asn Gly Arg Tyr Asp Ile Ser Lys Ile Pro
     710                 715                 720

 gac ata tat gac tgt ata aaa tat gat gtc cag cat aat ggt tcc ttg     2681
 Asp Ile Tyr Asp Cys Ile Lys Tyr Asp Val Gln His Asn Gly Ser Leu
 725                 730                 735                 740

 aaa tta gaa aac aca atg gaa tta tat agg ctt tcg aag gca tta gca     2729
 Lys Leu Glu Asn Thr Met Glu Leu Tyr Arg Leu Ser Lys Ala Leu Ala
                 745                 750                 755

 gat att gtt atc cct cag gaa tat ggt ata act aaa gct gaa aaa ctg     2777
 Asp Ile Val Ile Pro Gln Glu Tyr Gly Ile Thr Lys Ala Glu Lys Leu
             760                 765                 770

 gag att gcc aaa ggc tac tgt act cct ctg gtt aga aaa att cgc tca     2825
 Glu Ile Ala Lys Gly Tyr Cys Thr Pro Leu Val Arg Lys Ile Arg Ser
         775                 780                 785

 gac ctt cag agg aca caa gat gat gac act gta aat aaa ctt cat cct     2873
 Asp Leu Gln Arg Thr Gln Asp Asp Asp Thr Val Asn Lys Leu His Pro
     790                 795                 800

 gtg tat tct aga ggt gtt ctg tct cct gaa cgt cat gtt cgt act aga     2921
 Val Tyr Ser Arg Gly Val Leu Ser Pro Glu Arg His Val Arg Thr Arg
 805                 810                 815                 820

 tta tat ttt acc agt gaa agt cat gta cat tct ttg ctg tct att ctt     2969
 Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu Leu Ser Ile Leu
                 825                 830                 835

 cgc tat ggt gcc tta tgc aat gaa tca aag gat gaa cag tgg aaa cga     3017
 Arg Tyr Gly Ala Leu Cys Asn Glu Ser Lys Asp Glu Gln Trp Lys Arg
             840                 845                 850

 gct atg gat tat tta aac gtt gtc aat gag ctc aac tac atg act cag     3065
 Ala Met Asp Tyr Leu Asn Val Val Asn Glu Leu Asn Tyr Met Thr Gln
         855                 860                 865

 att gtt atc atg ctt tat gag gat cct aat aag gat ctt tcc tca gaa     3113
 Ile Val Ile Met Leu Tyr Glu Asp Pro Asn Lys Asp Leu Ser Ser Glu
     870                 875                 880

 gaa cgc ttt cat gtt gaa tta cac ttt agt ccg gga gcc aaa ggt tgt     3161
 Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly Ala Lys Gly Cys
 885                 890                 895                 900

 gaa gaa gac aaa aat ttg cca tct ggc tat gga tat aga cca gct tcc     3209
 Glu Glu Asp Lys Asn Leu Pro Ser Gly Tyr Gly Tyr Arg Pro Ala Ser
                 905                 910                 915

 aga gag aat gaa ggc agg aga cct ttt aaa att gat aat gat gat gaa     3257
 Arg Glu Asn Glu Gly Arg Arg Pro Phe Lys Ile Asp Asn Asp Asp Glu
             920                 925                 930

 cca cat act tct aaa aga gat gaa gtt gat cga gct gtg ata ttg ttt     3305
 Pro His Thr Ser Lys Arg Asp Glu Val Asp Arg Ala Val Ile Leu Phe
         935                 940                 945

 aaa cca atg gta tca gag cca att cat ata cac agg aag tct cca ctt     3353
 Lys Pro Met Val Ser Glu Pro Ile His Ile His Arg Lys Ser Pro Leu
     950                 955                 960

 cca aga tct agg aag acg gct aca aat gat gaa gag agc ccc ctg agt     3401
 Pro Arg Ser Arg Lys Thr Ala Thr Asn Asp Glu Glu Ser Pro Leu Ser
 965                 970                 975                 980

 gtg tct agc cca gag ggt act ggt acc tgg ctg cat tat acc agt ggt     3449
 Val Ser Ser Pro Glu Gly Thr Gly Thr Trp Leu His Tyr Thr Ser Gly
                 985                 990                 995

 gtg ggt act ggg cgt cga aga cgc aga tca ggg gaa caa atc act tct     3497
 Val Gly Thr Gly Arg Arg Arg Arg Arg Ser Gly Glu Gln Ile Thr Ser
            1000                1005                1010

 tcc cct gtc tcc ccc aaa tca ttg gct ttc aca tcc agt att ttt ggc     3545
 Ser Pro Val Ser Pro Lys Ser Leu Ala Phe Thr Ser Ser Ile Phe Gly
        1015                1020                1025

 tca tgg caa cag gtt gta tct gaa aat gct aat tac ctg aga aca cca     3593
 Ser Trp Gln Gln Val Val Ser Glu Asn Ala Asn Tyr Leu Arg Thr Pro
    1030                1035                1040

 aga act ctt gtg gaa cag aag cag aat cct act gta ggg tct cac tgt     3641
 Arg Thr Leu Val Glu Gln Lys Gln Asn Pro Thr Val Gly Ser His Cys
1045                1050                1055                1060

 gcg ggc ctg ttt agc acc tcg gtg ctc ggg ggt tct tca agc gca cct     3689
 Ala Gly Leu Phe Ser Thr Ser Val Leu Gly Gly Ser Ser Ser Ala Pro
                1065                1070                1075

 aac cta cag gat tat gct cgt act cat cgt aaa aag ctg acc tct tct     3737
 Asn Leu Gln Asp Tyr Ala Arg Thr His Arg Lys Lys Leu Thr Ser Ser
            1080                1085                1090

 ggc tgc ata gat gac gcc aca cgc ggt tct gct gtt aaa agg ttt tct     3785
 Gly Cys Ile Asp Asp Ala Thr Arg Gly Ser Ala Val Lys Arg Phe Ser
        1095                1100                1105

 atc tca ttt gct cga cac cca acc aat ggc ttt gaa ttg tat tcc atg     3833
 Ile Ser Phe Ala Arg His Pro Thr Asn Gly Phe Glu Leu Tyr Ser Met
    1110                1115                1120

 gtg cca tct att tgt cct cta gaa act ctt cat aat gcc cta tct tta     3881
 Val Pro Ser Ile Cys Pro Leu Glu Thr Leu His Asn Ala Leu Ser Leu
1125                1130                1135                1140

 aag caa gtg gat gaa ttt ctt gct tcc att gct tct cca tca tct gac     3929
 Lys Gln Val Asp Glu Phe Leu Ala Ser Ile Ala Ser Pro Ser Ser Asp
                1145                1150                1155

 gtt cca cgg aag acc gct gaa att tcc tct aca gct tta cgt tcc agt     3977
 Val Pro Arg Lys Thr Ala Glu Ile Ser Ser Thr Ala Leu Arg Ser Ser
            1160                1165                1170

 cca ata atg aga aaa aaa gta tct tta aat acg tat aca cct gca aag     4025
 Pro Ile Met Arg Lys Lys Val Ser Leu Asn Thr Tyr Thr Pro Ala Lys
        1175                1180                1185

 atc ctc cca aca cca cca gct acc tta aag agc act aaa gca agc agc     4073
 Ile Leu Pro Thr Pro Pro Ala Thr Leu Lys Ser Thr Lys Ala Ser Ser
    1190                1195                1200

 aaa cca gct aca agt gga cct tct agt gca gtt gtt cct aat acc tca     4121
 Lys Pro Ala Thr Ser Gly Pro Ser Ser Ala Val Val Pro Asn Thr Ser
1205                1210                1215                1220

 tct cgg aaa aag aat ata act agc aaa aca gaa acg cat gaa cac aaa     4169
 Ser Arg Lys Lys Asn Ile Thr Ser Lys Thr Glu Thr His Glu His Lys
                1225                1230                1235

 aaa aac act ggg aaa aag aaa tga aatcttagca gaagctggaa ctttttatac    4223
 Lys Asn Thr Gly Lys Lys Lys 
            1240

 ttataaaaat agtatgttct tatgtttctc cttatgcatt tatgtgttca cttaaaaatg   4283

 tttttaaatc taaggttttc tttgtttatg ttcaggtaag gaactgttgt catgatctgg   4343

 aaatgtttaa aacaatgttt gttagcattc tgtgagcagc aaaacttata gtgataaaaa   4403

 tcgattgttg ttaatatgat gtttaccatg tgcacatagt aatgaaaagg aacataaaag   4463

 cccagcaggc tcgtaccaaa gtcacagcag taatgctatg tactgcagag tctgatgagc   4523

 tggcctttgt gcacactttt attttcatgg gattgcatct tagctgttaa aacttctaga   4583

 ttgaaatttg acagccaggg ttacatattg gggactttta aagtgtcttt ccaaagagat   4643

 ttcattaacc gtttagatta gaatatcttt cccaattgtt acagtgacat atatgctgca   4703

 atatttaaca actggagtat tagccacatg ggttattttt tcaatctgtg ttttgaattt   4763

 ttttattgtg tgttatttaa aatattacat atgcagctgg gagaactaca cctttgtgca   4823

 catagattta tatattaatt tgtagaaaat attttcttta tatatttcct taccatacaa   4883

 ggtgccttgt tcatcaggaa aacttttgtt ttgtattttg acaagaaagg caccttcaga   4943

 gtttcttttt aagtatagtt gacaagtgta taaatgttac acttactttc agagttcttt   5003

 ttagatctaa agaagtcagt tcaaaaatgg aaatcaacaa tgttaggaga aatctgaatt   5063

 ctgttaagtt agtaagtatt atgtatagca tctgttttta accatttcca ttcttatccc   5123

 tagtgtatca gttgatcaca ctaagaaagc ttaaagattg agcatttgaa ataaatgctc   5183

 tttataaatg attagatttt tgaagggata ttgaaatcat tgcgctgtga tttcatctgt   5243

 gatgtgaaaa atcaatttat tatccttggt gctttccccc ccaccaatgc acaaataatt   5303

 gtgaacagct tgaaatgact taaactgtaa tccaaatggg acaatctgat aagaatttca   5363

 tgcattggta gttaaataac ttaaattgct aaagctttag cttgaaattt atgtttagaa   5423

 aaactattga tttcccatgg tatgaatata actattgtaa ttcttcaaat gagactcttc   5483

 tcaccttaaa tagtcatata ttaattaact tataggaaat aagcatacta tatgttagct   5543

 gttttaaaag gtaccagatg taagagtcat aaatatatgc aattaaagaa gttcatagat   5603

 ttcacatgaa tgtaaatgtg ttatatggag acatgtcttg taaacagttg aatgtatgta   5663

 agttttctgt ttgtgaaaat gtagttaatg tactcactgt ggaggtcata aggaagctac   5723

 ttttttttta aagtggaacc taattaaaat atttccagaa tcagtcgacg cggccgcgaa   5783

 ttcggatcct cgagagatct ctttttttgg gtttggtggg gtatcttcat catcgaatag   5843

 atagttatat catgtctcaa agctca                                        5869




      <210> 351
      <211> 6149
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (744)..(5432)

      <400> 351
 aattggctca tttaagaatt tcaaaacatt taatgtaaaa gctttttttt ttttaaggaa     60

 gtccataaat tttggttccc agggttgcac tggacttgga aggagtgctg ttgtgtacat    120

 actattgtat ggttttattt attattttac tgtacaaatc agccgaaaga atttttccaa    180

 gtgccatttc ggatttatta atcctttttt ttttcctttc ctcaaagata tttgctgttg    240

 tcatattaag cattggagac tagaaaatta ctttccccct ttgagctaga gggtctcttg    300

 ccaacagaag gacagctgag aaagctggat ttaaaggatg gttttatctg tactttgcag    360

 ttaacagtga tattttgaag gcacattttt ctgtgattca tttttttttg gccatagtgc    420

 taaccttgaa gagattcgtg gctgggtttt tggtttctga gaaggtcgta gtttttcctc    480

 ttttcctttt tttttctttt ttcttttctt ttcttttttt ttaaagcggg ggaggggaag    540

 aggggctgag aaaggaaatc atgttcactg gtagaagtag agtggagcat cagttaccag    600

 ggtcctgaga gctggaggag aaaggattct atcttcaagt tgggaggccc tcctctcacc    660

 ttgctcaaaa attgcaagcg attcaatcct gatcaagaca ccaaagctac aggattctgg    720

 aaccgtggag acaccgagaa acc    atg agt gta agg tta ccc cag agt ata     770
                              Met Ser Val Arg Leu Pro Gln Ser Ile
                                1               5

 gac agg tta agt agc ctg tct tct ctg gga gat tct gca cca gag cgc      818
 Asp Arg Leu Ser Ser Leu Ser Ser Leu Gly Asp Ser Ala Pro Glu Arg
  10                  15                  20                  25

 aag tcc cct tcc cac cat cgc cag cct tcg gat gcc tct gag aca aca      866
 Lys Ser Pro Ser His His Arg Gln Pro Ser Asp Ala Ser Glu Thr Thr
                  30                  35                  40

 ggt ctc gtt caa cgc tgt gtc att atc caa aag gac cag cat ggc ttc      914
 Gly Leu Val Gln Arg Cys Val Ile Ile Gln Lys Asp Gln His Gly Phe
              45                  50                  55

 ggc ttc aca gtc agt ggg gat cgc att gtt ctg gtg cag tct gtg cgg      962
 Gly Phe Thr Val Ser Gly Asp Arg Ile Val Leu Val Gln Ser Val Arg
          60                  65                  70

 cct gga ggt gca gcc atg aag gcc ggt gtg aaa gag ggc gac cgg atc     1010
 Pro Gly Gly Ala Ala Met Lys Ala Gly Val Lys Glu Gly Asp Arg Ile
      75                  80                  85

 atc aaa gtc aac ggc acc atg gtg acc aat agc tca cac ctg gaa gtg     1058
 Ile Lys Val Asn Gly Thr Met Val Thr Asn Ser Ser His Leu Glu Val
  90                  95                 100                 105

 gta aag ctg atc aaa tct ggc gcc tat gtc gca ctc acc ctc ctg ggc     1106
 Val Lys Leu Ile Lys Ser Gly Ala Tyr Val Ala Leu Thr Leu Leu Gly
                 110                 115                 120

 tct tca cct tca tcc atg ggc atc tct ggg ctc cag cag gac cca tcc     1154
 Ser Ser Pro Ser Ser Met Gly Ile Ser Gly Leu Gln Gln Asp Pro Ser
             125                 130                 135

 cca gca gga gct ccc cga atc acg tca gtg atc ccc tca cca cca cct     1202
 Pro Ala Gly Ala Pro Arg Ile Thr Ser Val Ile Pro Ser Pro Pro Pro
         140                 145                 150

 cct cca cct cta cca cct cca caa cgc atc aca gga ccc aaa cct ctg     1250
 Pro Pro Pro Leu Pro Pro Pro Gln Arg Ile Thr Gly Pro Lys Pro Leu
     155                 160                 165

 cag gat ccc gaa gtt caa aaa cat gcc acc cag atc ctc agg aat atg     1298
 Gln Asp Pro Glu Val Gln Lys His Ala Thr Gln Ile Leu Arg Asn Met
 170                 175                 180                 185

 ctg agg cag gaa aaa aaa gaa tta cag cgt atc tgt gag gtc tat agc     1346
 Leu Arg Gln Glu Lys Lys Glu Leu Gln Arg Ile Cys Glu Val Tyr Ser
                 190                 195                 200

 cgg aac ccc gcc agc cta ctg gaa gag cag atc gaa ggt gcc cgg cgg     1394
 Arg Asn Pro Ala Ser Leu Leu Glu Glu Gln Ile Glu Gly Ala Arg Arg
             205                 210                 215

 cga gtc act cag tta cag ctg aag atc cag cag gag act ggt ggc tca     1442
 Arg Val Thr Gln Leu Gln Leu Lys Ile Gln Gln Glu Thr Gly Gly Ser
         220                 225                 230

 gtg gac ata ctt cca cta tat ggt gac acc agc cag aga cca tca gaa     1490
 Val Asp Ile Leu Pro Leu Tyr Gly Asp Thr Ser Gln Arg Pro Ser Glu
     235                 240                 245

 ggc cgg ctc tct ctg gat tcc cag gag ggg gac agt ggc ttg gac tct     1538
 Gly Arg Leu Ser Leu Asp Ser Gln Glu Gly Asp Ser Gly Leu Asp Ser
 250                 255                 260                 265

 ggg aca gaa cgc ttt cct tcc ctc agt gag tca ttg atg aat cgg aac     1586
 Gly Thr Glu Arg Phe Pro Ser Leu Ser Glu Ser Leu Met Asn Arg Asn
                 270                 275                 280

 tcg gta ctg tca gac cct ggg cta gac agt cct cga acc tcc cct gtg     1634
 Ser Val Leu Ser Asp Pro Gly Leu Asp Ser Pro Arg Thr Ser Pro Val
             285                 290                 295

 atc atg gcc agg gtg gcc cag cac cac agg cgg cag ggc tcg gat gca     1682
 Ile Met Ala Arg Val Ala Gln His His Arg Arg Gln Gly Ser Asp Ala
         300                 305                 310

 gca gtc ccc tca acc ggt gac cag ggt gta gat caa agc cca aag cct     1730
 Ala Val Pro Ser Thr Gly Asp Gln Gly Val Asp Gln Ser Pro Lys Pro
     315                 320                 325

 tta att att ggc cca gag gaa gac tat gac ccg ggt tat ttc aac aac     1778
 Leu Ile Ile Gly Pro Glu Glu Asp Tyr Asp Pro Gly Tyr Phe Asn Asn
 330                 335                 340                 345

 gag agc gac atc ata ttc cag gat ctg gag aaa ctg aag tct cgg cca     1826
 Glu Ser Asp Ile Ile Phe Gln Asp Leu Glu Lys Leu Lys Ser Arg Pro
                 350                 355                 360

 gct cac ctg ggg gtt ttt cta cgt tac atc ttc tct cag gcg gac ccc     1874
 Ala His Leu Gly Val Phe Leu Arg Tyr Ile Phe Ser Gln Ala Asp Pro
             365                 370                 375

 agt cca ctg ctt ttt tac ctg tgt gca gaa gtt tat cag cag gca agc     1922
 Ser Pro Leu Leu Phe Tyr Leu Cys Ala Glu Val Tyr Gln Gln Ala Ser
         380                 385                 390

 ccc aag gat tcc cga agc ttg ggg aaa gac atc tgg aat att ttc ctg     1970
 Pro Lys Asp Ser Arg Ser Leu Gly Lys Asp Ile Trp Asn Ile Phe Leu
     395                 400                 405

 gag aaa aat gcg cct ctg aga gtg aag atc cct gag atg cta cag gct     2018
 Glu Lys Asn Ala Pro Leu Arg Val Lys Ile Pro Glu Met Leu Gln Ala
 410                 415                 420                 425

 gaa att gac tcg cgc ctg cgg aac agc gaa gat gcc cgt ggt gtt ctc     2066
 Glu Ile Asp Ser Arg Leu Arg Asn Ser Glu Asp Ala Arg Gly Val Leu
                 430                 435                 440

 tgt gaa gct caa gag gca gcc atg cct gag atc caa gag cag atc cac     2114
 Cys Glu Ala Gln Glu Ala Ala Met Pro Glu Ile Gln Glu Gln Ile His
             445                 450                 455

 gac tac aga acg aag cgc aca ctg ggg ctg ggc agc ctg tat ggt gaa     2162
 Asp Tyr Arg Thr Lys Arg Thr Leu Gly Leu Gly Ser Leu Tyr Gly Glu
         460                 465                 470

 aat gac ctg ctg gac ctg gat ggg gac cct ctc cga gag cgc caa gtg     2210
 Asn Asp Leu Leu Asp Leu Asp Gly Asp Pro Leu Arg Glu Arg Gln Val
     475                 480                 485

 gct gag aag cag ctg gct gcc ctt gga gat att ttg tcc aag tat gag     2258
 Ala Glu Lys Gln Leu Ala Ala Leu Gly Asp Ile Leu Ser Lys Tyr Glu
 490                 495                 500                 505

 gaa gac agg agc gcc ccc atg gac ttc gcc ctc aat acc tac atg agc     2306
 Glu Asp Arg Ser Ala Pro Met Asp Phe Ala Leu Asn Thr Tyr Met Ser
                 510                 515                 520

 cat gct ggg atc cgt ctt cga gag gca cga cct tcc aac aca gct gaa     2354
 His Ala Gly Ile Arg Leu Arg Glu Ala Arg Pro Ser Asn Thr Ala Glu
             525                 530                 535

 aag gcc cag tct gct cct gac aag gac aag tgg cta ccg ttc ttc cct     2402
 Lys Ala Gln Ser Ala Pro Asp Lys Asp Lys Trp Leu Pro Phe Phe Pro
         540                 545                 550

 aag acc aag aag agc agc aat tcc aag aaa gaa aag gat gcc ttg gag     2450
 Lys Thr Lys Lys Ser Ser Asn Ser Lys Lys Glu Lys Asp Ala Leu Glu
     555                 560                 565

 gac aag aag cga aac cct atc ctc aaa tac att ggg aag ccc aaa agc     2498
 Asp Lys Lys Arg Asn Pro Ile Leu Lys Tyr Ile Gly Lys Pro Lys Ser
 570                 575                 580                 585

 tct tct caa agc aca ttt cat att ccc ttg tcc cct gtg gaa gtc aaa     2546
 Ser Ser Gln Ser Thr Phe His Ile Pro Leu Ser Pro Val Glu Val Lys
                 590                 595                 600

 cca ggc aat gtg agg aac atc att cag cac ttt gag aac aac cag cag     2594
 Pro Gly Asn Val Arg Asn Ile Ile Gln His Phe Glu Asn Asn Gln Gln
             605                 610                 615

 tat gat gcc cca gaa cct ggg aca caa cga ctc tcg acc gga agc ttt     2642
 Tyr Asp Ala Pro Glu Pro Gly Thr Gln Arg Leu Ser Thr Gly Ser Phe
         620                 625                 630

 cct gag gac ctg ctg gag agt gac agt tca cgc tca gag att cgc ctg     2690
 Pro Glu Asp Leu Leu Glu Ser Asp Ser Ser Arg Ser Glu Ile Arg Leu
     635                 640                 645

 ggc cgc tct gaa agc ctc aag ggc cgg gaa gag atg aaa cgg tct cga     2738
 Gly Arg Ser Glu Ser Leu Lys Gly Arg Glu Glu Met Lys Arg Ser Arg
 650                 655                 660                 665

 aag gca gag aac gtg ccc cgc tct cgc agt gat gtt gac atg gat gct     2786
 Lys Ala Glu Asn Val Pro Arg Ser Arg Ser Asp Val Asp Met Asp Ala
                 670                 675                 680

 gct gcg gag gct act cgc ctg cac cag tca gcc tcg tcc tct acc tcc     2834
 Ala Ala Glu Ala Thr Arg Leu His Gln Ser Ala Ser Ser Ser Thr Ser
             685                 690                 695

 agc ctc tcc acc agg tct ctt gag aac cca acc cct cca ttc act ccc     2882
 Ser Leu Ser Thr Arg Ser Leu Glu Asn Pro Thr Pro Pro Phe Thr Pro
         700                 705                 710

 aaa atg ggc cgc agg agc att gag tcc ccc agt ttg ggg ttc tgc aca     2930
 Lys Met Gly Arg Arg Ser Ile Glu Ser Pro Ser Leu Gly Phe Cys Thr
     715                 720                 725

 gat acc ctc ctt ccc cac ctc cta gag gat gat ctg ggc cag ctg tct     2978
 Asp Thr Leu Leu Pro His Leu Leu Glu Asp Asp Leu Gly Gln Leu Ser
 730                 735                 740                 745

 gac ctg gag cca gag cca gat gcc caa aat tgg cag cat aca gtg ggc     3026
 Asp Leu Glu Pro Glu Pro Asp Ala Gln Asn Trp Gln His Thr Val Gly
                 750                 755                 760

 aag gat gtg gtg gct ggg cta acc cag cgg gag att gac cgg caa gag     3074
 Lys Asp Val Val Ala Gly Leu Thr Gln Arg Glu Ile Asp Arg Gln Glu
             765                 770                 775

 gtc atc aat gag ctg ttt gtg act gaa gct tcc cac ctg cgc aca ctc     3122
 Val Ile Asn Glu Leu Phe Val Thr Glu Ala Ser His Leu Arg Thr Leu
         780                 785                 790

 cgg gtc ctg gac ctg atc ttc tac cag cga atg aag aag gag aac ctg     3170
 Arg Val Leu Asp Leu Ile Phe Tyr Gln Arg Met Lys Lys Glu Asn Leu
     795                 800                 805

 atg ccc cgg gag gag ctg gcc cgg ctc ttc ccg aac ctg cct gaa ctc     3218
 Met Pro Arg Glu Glu Leu Ala Arg Leu Phe Pro Asn Leu Pro Glu Leu
 810                 815                 820                 825

 ata gag att cac aat tcc tgg tgt gaa gcc atg aag aag ctc cgg gag     3266
 Ile Glu Ile His Asn Ser Trp Cys Glu Ala Met Lys Lys Leu Arg Glu
                 830                 835                 840

 gaa ggc ccc atc atc aaa gag atc agt gac ctc atg ctg gcc cgg ttt     3314
 Glu Gly Pro Ile Ile Lys Glu Ile Ser Asp Leu Met Leu Ala Arg Phe
             845                 850                 855

 gat ggc cct gcc cga gag gaa ctc cag caa gtg gct gca cag ttc tgt     3362
 Asp Gly Pro Ala Arg Glu Glu Leu Gln Gln Val Ala Ala Gln Phe Cys
         860                 865                 870

 tcc tat cag tca ata gcc cta gag cta atc aag acc aag caa cgc aag     3410
 Ser Tyr Gln Ser Ile Ala Leu Glu Leu Ile Lys Thr Lys Gln Arg Lys
     875                 880                 885

 gag agt cga ttc cag ctc ttc atg cag gag gct gag agc cac cct cag     3458
 Glu Ser Arg Phe Gln Leu Phe Met Gln Glu Ala Glu Ser His Pro Gln
 890                 895                 900                 905

 tgt cgg cgg ctg cag ctg aga gac ctc atc atc tct gag atg cag cgg     3506
 Cys Arg Arg Leu Gln Leu Arg Asp Leu Ile Ile Ser Glu Met Gln Arg
                 910                 915                 920

 ctc acc aag tac ccg ctg ctg ctg gag agc atc atc aag cac aca gag     3554
 Leu Thr Lys Tyr Pro Leu Leu Leu Glu Ser Ile Ile Lys His Thr Glu
             925                 930                 935

 ggt ggc acc tct gag cat gag aag ctg tgc cgg gcc cgg gac cag tgc     3602
 Gly Gly Thr Ser Glu His Glu Lys Leu Cys Arg Ala Arg Asp Gln Cys
         940                 945                 950

 cgg gag att ctc aag tat gtg aat gaa gcg gta aaa caa aca gag aac     3650
 Arg Glu Ile Leu Lys Tyr Val Asn Glu Ala Val Lys Gln Thr Glu Asn
     955                 960                 965

 cgc cac cgt tta gag ggc tac cag aaa cgc ctg gat gcc acc gcc ctg     3698
 Arg His Arg Leu Glu Gly Tyr Gln Lys Arg Leu Asp Ala Thr Ala Leu
 970                 975                 980                 985

 gag agg gcc agc aac ccc ctg gca gca gag ttc aag agc ctg gat ctt     3746
 Glu Arg Ala Ser Asn Pro Leu Ala Ala Glu Phe Lys Ser Leu Asp Leu
                 990                 995                1000

 aca acc aga aaa atg atc cat gag gga ccc ctg acc tgg agg atc agc     3794
 Thr Thr Arg Lys Met Ile His Glu Gly Pro Leu Thr Trp Arg Ile Ser
            1005                1010                1015

 aag gat aag acc ttg gac ctc cac gtg ctg ctg ctg gag gac ctc cta     3842
 Lys Asp Lys Thr Leu Asp Leu His Val Leu Leu Leu Glu Asp Leu Leu
        1020                1025                1030

 gtg ctg cta cag aaa cag gat gag aag cta ttg ctg aag tgc cac agc     3890
 Val Leu Leu Gln Lys Gln Asp Glu Lys Leu Leu Leu Lys Cys His Ser
    1035                1040                1045

 aag act gct gtg ggc tcc tca gac agc aag cag acc ttc agc ccc gtg     3938
 Lys Thr Ala Val Gly Ser Ser Asp Ser Lys Gln Thr Phe Ser Pro Val
1050                1055                1060                1065

 ctc aag ctc aat gct gtg ctc atc cgc tct gtg gcc aca gat aaa cgg     3986
 Leu Lys Leu Asn Ala Val Leu Ile Arg Ser Val Ala Thr Asp Lys Arg
                1070                1075                1080

 gcc ttc ttc atc atc tgc acc tcc aag ctg ggc cca ccc cag atc tat     4034
 Ala Phe Phe Ile Ile Cys Thr Ser Lys Leu Gly Pro Pro Gln Ile Tyr
            1085                1090                1095

 gag ctg gtt gca ttg acg tca tca gac aag aac aca tgg atg gag ctc     4082
 Glu Leu Val Ala Leu Thr Ser Ser Asp Lys Asn Thr Trp Met Glu Leu
        1100                1105                1110

 tta gaa gag gcc gtg cgg aat gcc acc agg cac ccc gga gct gcc cca     4130
 Leu Glu Glu Ala Val Arg Asn Ala Thr Arg His Pro Gly Ala Ala Pro
    1115                1120                1125

 atg ccc gtc cat cct cca ccc cca ggt ccc cgg gag cca gcc cag cag     4178
 Met Pro Val His Pro Pro Pro Pro Gly Pro Arg Glu Pro Ala Gln Gln
1130                1135                1140                1145

 ggc ccc aca ccc agc agg gta gaa ctg gat gac tca gac gtg ttc cat     4226
 Gly Pro Thr Pro Ser Arg Val Glu Leu Asp Asp Ser Asp Val Phe His
                1150                1155                1160

 ggt gaa cct gaa cct gag gag ctg cct gga ggc act ggg tcc cag cag     4274
 Gly Glu Pro Glu Pro Glu Glu Leu Pro Gly Gly Thr Gly Ser Gln Gln
            1165                1170                1175

 agg gtc caa ggg aag cac cag gtc ctg cta gag gac cct gag cag gag     4322
 Arg Val Gln Gly Lys His Gln Val Leu Leu Glu Asp Pro Glu Gln Glu
        1180                1185                1190

 ggc agt gca gag gaa gag gaa ctg ggt gtc ctg cct tgc cct tcc aca     4370
 Gly Ser Ala Glu Glu Glu Glu Leu Gly Val Leu Pro Cys Pro Ser Thr
    1195                1200                1205

 tcc ctg gat gga gag aac agg ggc atc agg aca agg aac ccc atc cac     4418
 Ser Leu Asp Gly Glu Asn Arg Gly Ile Arg Thr Arg Asn Pro Ile His
1210                1215                1220                1225

 ttg gcc ttc cca ggc cct ctg ttc atg gaa ggg ctc gct gac tcc gct     4466
 Leu Ala Phe Pro Gly Pro Leu Phe Met Glu Gly Leu Ala Asp Ser Ala
                1230                1235                1240

 ctg gaa gat gtg gag aac ctg cga cat ctg atc ctg tgg agc ctg ctg     4514
 Leu Glu Asp Val Glu Asn Leu Arg His Leu Ile Leu Trp Ser Leu Leu
            1245                1250                1255

 cca ggt cac acc atg gaa act cag gct gcc cag gag ccc gag gac gac     4562
 Pro Gly His Thr Met Glu Thr Gln Ala Ala Gln Glu Pro Glu Asp Asp
        1260                1265                1270

 ctg aca ccc aca cct tct gtc atc agc gtc acc tct cac ccc tgg gac     4610
 Leu Thr Pro Thr Pro Ser Val Ile Ser Val Thr Ser His Pro Trp Asp
    1275                1280                1285

 cca ggc tcc cca ggg caa gca ccc cct ggg ggt gaa ggg gac aac acc     4658
 Pro Gly Ser Pro Gly Gln Ala Pro Pro Gly Gly Glu Gly Asp Asn Thr
1290                1295                1300                1305

 cag ctt gca ggg ctg gag ggg gaa cgg cca gag cag gaa gac atg ggt     4706
 Gln Leu Ala Gly Leu Glu Gly Glu Arg Pro Glu Gln Glu Asp Met Gly
                1310                1315                1320

 ctc tgt tct ctg gaa cac cta ccc cca agg acc aga aat tct ggg ata     4754
 Leu Cys Ser Leu Glu His Leu Pro Pro Arg Thr Arg Asn Ser Gly Ile
            1325                1330                1335

 tgg gag tct cca gaa ctg gac agg aat ctg gct gaa gat gct tca agc     4802
 Trp Glu Ser Pro Glu Leu Asp Arg Asn Leu Ala Glu Asp Ala Ser Ser
        1340                1345                1350

 aca gag gca gca gga ggt tac aaa gtt gtg aga aaa gct gag gtg gca     4850
 Thr Glu Ala Ala Gly Gly Tyr Lys Val Val Arg Lys Ala Glu Val Ala
    1355                1360                1365

 ggc agc aag gtt gtc cct gca cta cca gag agt ggc cag tca gag cct     4898
 Gly Ser Lys Val Val Pro Ala Leu Pro Glu Ser Gly Gln Ser Glu Pro
1370                1375                1380                1385

 ggg cca cct gaa gtg gaa ggc gga aca aag gct acg ggg aac tgc ttt     4946
 Gly Pro Pro Glu Val Glu Gly Gly Thr Lys Ala Thr Gly Asn Cys Phe
                1390                1395                1400

 tat gtc agc atg cca tca gga ccc ccg gac tca agc acc gac cac tca     4994
 Tyr Val Ser Met Pro Ser Gly Pro Pro Asp Ser Ser Thr Asp His Ser
            1405                1410                1415

 gag gca ccc atg agc ccc cct cag cct gac agc ctc cct gca ggg cag     5042
 Glu Ala Pro Met Ser Pro Pro Gln Pro Asp Ser Leu Pro Ala Gly Gln
        1420                1425                1430

 aca gag cct cag cct cag ctg cag gga ggc aac gat gat cca aga cgc     5090
 Thr Glu Pro Gln Pro Gln Leu Gln Gly Gly Asn Asp Asp Pro Arg Arg
    1435                1440                1445

 ccc agc cgc tct cct cca ggc ctg gcc ctc agg gac gtg ggc atg atc     5138
 Pro Ser Arg Ser Pro Pro Gly Leu Ala Leu Arg Asp Val Gly Met Ile
1450                1455                1460                1465

 ttc cat acc att gag cag ctc act ctc aag ctc aac agg ctc aag gat     5186
 Phe His Thr Ile Glu Gln Leu Thr Leu Lys Leu Asn Arg Leu Lys Asp
                1470                1475                1480

 atg gag ctg gcc cac aga gag ctg ctc aag tcc ctt ggg gga gag tca     5234
 Met Glu Leu Ala His Arg Glu Leu Leu Lys Ser Leu Gly Gly Glu Ser
            1485                1490                1495

 tct ggt ggc acc acg cct gtg ggc agt ttc cac aca gaa gca gct aga     5282
 Ser Gly Gly Thr Thr Pro Val Gly Ser Phe His Thr Glu Ala Ala Arg
        1500                1505                1510

 tgg aca gat ggc tcc ctc tca cct ccc gct aag gag ccc cta gct tct     5330
 Trp Thr Asp Gly Ser Leu Ser Pro Pro Ala Lys Glu Pro Leu Ala Ser
    1515                1520                1525

 gac tcc agg aac agc cat gaa ctg ggg ccc tgc cct gag gat ggc tct     5378
 Asp Ser Arg Asn Ser His Glu Leu Gly Pro Cys Pro Glu Asp Gly Ser
1530                1535                1540                1545

 gac gcc ccc ctg gaa gac agc aca gca gac gca gcc gcg tca cca gga     5426
 Asp Ala Pro Leu Glu Asp Ser Thr Ala Asp Ala Ala Ala Ser Pro Gly
                1550                1555                1560

 cca taa ccgtacaaac caccaaatcc tctgcgtccc cactcctcct tcagggactg      5482
 Pro 


 gcctgagacc ggggcacagg gtagggggga tcccaacact cctccctgtg gaggaggcag   5542

 ttagggaaac taggatccag ccaaggcccg gggggagacc cgcatgttgc ttggtctgct   5602

 caagtcggag tcaggtttca gtgtcttttc cctcccttag cccaaccctc caaggcctca   5662

 tgtctcctaa gcatgctgac tgcatccgaa aggcccccac tcaccatggt ctgccctcac   5722

 cccacatatg tgtgtacacg cgcacgcctg tatgtgcgct gccctcagac atgcaagtga   5782

 aaggaggagg cttctgtgta aatgcacttt cttcctcccc tctttctcca taagacccca   5842

 ggcagaggtg ggtgcctccc ctcccctctt tgtcactttg gtttcctata aatatgtatg   5902

 tatcgtatgt gcatctttgc tattgtaaat aactttgacc ttttttgttc ctgttcctga   5962

 agtgctggag gcagttatgg aaggagctgc ttagggaaga ggggtttcac ttgtatctcc   6022

 ttagttaaca acccagttcc aggatcgagc ctaaagcggg agccaggcct gagtgttcct   6082

 gtccctgtga gtgggaaggt cttctggctc cccatcccac ctggctccag agcctgccct   6142

 ccacagc                                                             6149




      <210> 352
      <211> 1763
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (296)..(1753)

      <400> 352
 cattaatcct ccactcaacc ttcaagaaac tcaagtcact atagaagaaa tcactcctct     60

 tgtcccccca caatcaggag ataaagggca agaagatctc acaagctatt ttcttgaagc    120

 acttctaaaa tacatagtca ttcaggtaaa aagtttagaa tggaagaaca aagaaaacca    180

 agaaagggga ttttcatttt tgttttcaca ttttaagaaa tattacttgc cttatatttt    240

 tccaaacatc tgtaaggaaa acagtttata tcatcctata cttgacatcc cgcag atg     298
                                                              Met
                                                                1

 aga cca aag cca cat tat gtc gtg ata aag aaa gat gct gaa acc aat      346
 Arg Pro Lys Pro His Tyr Val Val Ile Lys Lys Asp Ala Glu Thr Asn
               5                  10                  15

 gaa gca atc tat tgt aca aag gag cct ttc att aag gct cgt gtt att      394
 Glu Ala Ile Tyr Cys Thr Lys Glu Pro Phe Ile Lys Ala Arg Val Ile
          20                  25                  30

 gtc att cgt tgg ctg gtt tct ttc tgg ctg gag cca aaa cca cat aca      442
 Val Ile Arg Trp Leu Val Ser Phe Trp Leu Glu Pro Lys Pro His Thr
      35                  40                  45

 gga cct cat att cct ggg atg gaa ggt gaa gtc ttg cca aag aat att      490
 Gly Pro His Ile Pro Gly Met Glu Gly Glu Val Leu Pro Lys Asn Ile
  50                  55                  60                  65

 cag aga gca gct gct agt tta gta tcc aga gaa gaa agc aaa aat gat      538
 Gln Arg Ala Ala Ala Ser Leu Val Ser Arg Glu Glu Ser Lys Asn Asp
                  70                  75                  80

 aat gct gat aaa aca gac aga act aca gaa cct gaa cag tct cat tcc      586
 Asn Ala Asp Lys Thr Asp Arg Thr Thr Glu Pro Glu Gln Ser His Ser
              85                  90                  95

 aat aca agc act ctc acg gag cga gaa cct agc tca tct agt ctc tgt      634
 Asn Thr Ser Thr Leu Thr Glu Arg Glu Pro Ser Ser Ser Ser Leu Cys
         100                 105                 110

 agt att gat gaa gaa cat ctc aca gac att gaa ata gtt cgc aga gtt      682
 Ser Ile Asp Glu Glu His Leu Thr Asp Ile Glu Ile Val Arg Arg Val
     115                 120                 125

 ttt tct tct aaa agg agt aat gta aac ttt gtg aca gag ata ttt cgt      730
 Phe Ser Ser Lys Arg Ser Asn Val Asn Phe Val Thr Glu Ile Phe Arg
 130                 135                 140                 145

 cag gca ttt tta tta cca att tgt gaa gca gca gct atg aga aaa gtg      778
 Gln Ala Phe Leu Leu Pro Ile Cys Glu Ala Ala Ala Met Arg Lys Val
                 150                 155                 160

 gta aaa gta tat caa gaa tgg atc caa caa gag gaa aaa cct ttg ttc      826
 Val Lys Val Tyr Gln Glu Trp Ile Gln Gln Glu Glu Lys Pro Leu Phe
             165                 170                 175

 atg caa gag cct gaa gaa att gtg atc act tct tca gac ctc cct tgc      874
 Met Gln Glu Pro Glu Glu Ile Val Ile Thr Ser Ser Asp Leu Pro Cys
         180                 185                 190

 att gaa aat gtc aca gac cat gat att tca atg gaa gaa gga gaa aaa      922
 Ile Glu Asn Val Thr Asp His Asp Ile Ser Met Glu Glu Gly Glu Lys
     195                 200                 205

 aga gaa gag gaa aat ggg acc aat act gct gat cat gtt cga aat tcc      970
 Arg Glu Glu Glu Asn Gly Thr Asn Thr Ala Asp His Val Arg Asn Ser
 210                 215                 220                 225

 agt tgg gca aaa aac ggc tcc tac caa ggt gct ctt cat aac gcc tct     1018
 Ser Trp Ala Lys Asn Gly Ser Tyr Gln Gly Ala Leu His Asn Ala Ser
                 230                 235                 240

 gaa gaa gcc aca gaa caa aac ata cga gct ggt acc cag gca gtt ttg     1066
 Glu Glu Ala Thr Glu Gln Asn Ile Arg Ala Gly Thr Gln Ala Val Leu
             245                 250                 255

 cag gtg ttt att ata aac tca tca aat ata ttt ctt ctt gaa cct gca     1114
 Gln Val Phe Ile Ile Asn Ser Ser Asn Ile Phe Leu Leu Glu Pro Ala
         260                 265                 270

 aat gaa ata aaa aat ctt ctg gat gaa cac aca gat atg tgt aaa cgc     1162
 Asn Glu Ile Lys Asn Leu Leu Asp Glu His Thr Asp Met Cys Lys Arg
     275                 280                 285

 att ctt aac att tat cgg tac atg gtt gta caa gta tca atg gac aaa     1210
 Ile Leu Asn Ile Tyr Arg Tyr Met Val Val Gln Val Ser Met Asp Lys
 290                 295                 300                 305

 aag act tgg gaa cag atg ctg ctt gtg ttg ctc aga gtc acg gaa tct     1258
 Lys Thr Trp Glu Gln Met Leu Leu Val Leu Leu Arg Val Thr Glu Ser
                 310                 315                 320

 gta ctg aag atg cca tca caa gct ttt cta cag ttc caa ggg aaa aaa     1306
 Val Leu Lys Met Pro Ser Gln Ala Phe Leu Gln Phe Gln Gly Lys Lys
             325                 330                 335

 aat atg acc ttg gca ggt cga ctt gca gga cca ctt ttc cag acc ctt     1354
 Asn Met Thr Leu Ala Gly Arg Leu Ala Gly Pro Leu Phe Gln Thr Leu
         340                 345                 350

 ata gtt gcc tgg atc aaa gca aac cta aat gtg tac atc tcc cga gaa     1402
 Ile Val Ala Trp Ile Lys Ala Asn Leu Asn Val Tyr Ile Ser Arg Glu
     355                 360                 365

 ctt tgg gat gac tta ctg tca gta ttg tca tcg ctg acc tat tgg gaa     1450
 Leu Trp Asp Asp Leu Leu Ser Val Leu Ser Ser Leu Thr Tyr Trp Glu
 370                 375                 380                 385

 gag ttg gcc act gag tgg tca ctg act atg gag aca tta act aaa gtt     1498
 Glu Leu Ala Thr Glu Trp Ser Leu Thr Met Glu Thr Leu Thr Lys Val
                 390                 395                 400

 tta gct agg aat tta tat agt ttg gat ctc agt gat tta cca ttg gat     1546
 Leu Ala Arg Asn Leu Tyr Ser Leu Asp Leu Ser Asp Leu Pro Leu Asp
             405                 410                 415

 aag ctg agt gaa cag aaa caa aaa aag cac aaa ggg aaa gga gtt gga     1594
 Lys Leu Ser Glu Gln Lys Gln Lys Lys His Lys Gly Lys Gly Val Gly
         420                 425                 430

 cat gaa ttt cag aaa gtc tca gtt gac aag tca ttt tct aga gga tgg     1642
 His Glu Phe Gln Lys Val Ser Val Asp Lys Ser Phe Ser Arg Gly Trp
     435                 440                 445

 agt cgt gat cag cct ggc caa gcc cca atg aga cag agg agt gca aca     1690
 Ser Arg Asp Gln Pro Gly Gln Ala Pro Met Arg Gln Arg Ser Ala Thr
 450                 455                 460                 465

 acc act ggt tct cca gga acc gaa aag gcg agg agt ata gta cgg caa     1738
 Thr Thr Gly Ser Pro Gly Thr Glu Lys Ala Arg Ser Ile Val Arg Gln
                 470                 475                 480

 aaa act gtc ggc taa tgaagaaaag                                      1763
 Lys Thr Val Gly 
             485





      <210> 353
      <211> 1490
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (151)..(1173)

      <400> 353
 agcaaaagag aaaaggagcc aggctgggct tcctgatccc acagcatcgc agagctcggg     60

 aggcacagct cacagacaca ggaaacacag gactgctatt ctgctctcct gcccacggtg    120

 atctggtgcc agctggtgga acagtgggtg     atg gcg tcc ctg ctg caa gac     171
                                      Met Ala Ser Leu Leu Gln Asp
                                        1               5

 cag ctg acc act gat cag gac ttg ctg ctg atg cag gaa ggc atg ccg      219
 Gln Leu Thr Thr Asp Gln Asp Leu Leu Leu Met Gln Glu Gly Met Pro
          10                  15                  20

 atg cgc aag gtg agg tcc aaa agc tgg aag aag cta aga tac ttc aga      267
 Met Arg Lys Val Arg Ser Lys Ser Trp Lys Lys Leu Arg Tyr Phe Arg
      25                  30                  35

 ctt cag aat gac ggc atg aca gtc tgg cat gca cgg cag gcc agg ggc      315
 Leu Gln Asn Asp Gly Met Thr Val Trp His Ala Arg Gln Ala Arg Gly
  40                  45                  50                  55

 agt gcc aag ccc agc ttc tca atc tct gat gtg gag aca ata cgt aat      363
 Ser Ala Lys Pro Ser Phe Ser Ile Ser Asp Val Glu Thr Ile Arg Asn
                  60                  65                  70

 ggc cat gat tcc gag ttg ctg cgt agc ctg gca gag gag ctc ccc ctg      411
 Gly His Asp Ser Glu Leu Leu Arg Ser Leu Ala Glu Glu Leu Pro Leu
              75                  80                  85

 gag cag ggc ttc acc att gtc ttc cat ggc cgc cgc tcc aac ctg gac      459
 Glu Gln Gly Phe Thr Ile Val Phe His Gly Arg Arg Ser Asn Leu Asp
          90                  95                 100

 ctg atg gcc aac agt gtt gag gag gcc cag ata tgg atg cga ggg ctc      507
 Leu Met Ala Asn Ser Val Glu Glu Ala Gln Ile Trp Met Arg Gly Leu
     105                 110                 115

 cag ctg ttg gtg gat ctt gtc acc agc atg gac cat cag gag cgc ctg      555
 Gln Leu Leu Val Asp Leu Val Thr Ser Met Asp His Gln Glu Arg Leu
 120                 125                 130                 135

 gac caa tgg ctg agc gat tgg ttt caa cgt gga gac aaa aat cag gat      603
 Asp Gln Trp Leu Ser Asp Trp Phe Gln Arg Gly Asp Lys Asn Gln Asp
                 140                 145                 150

 ggt aag atg agt ttc caa gaa gtt cag cgg tta ttg cac cta atg aat      651
 Gly Lys Met Ser Phe Gln Glu Val Gln Arg Leu Leu His Leu Met Asn
             155                 160                 165

 gtg gaa atg gac caa gaa tat gcc ttc agt ctt ttt cag gca gca gac      699
 Val Glu Met Asp Gln Glu Tyr Ala Phe Ser Leu Phe Gln Ala Ala Asp
         170                 175                 180

 acg tcc cag tct gga acc ctg gaa gga gaa gaa ttc gta cag ttc tat      747
 Thr Ser Gln Ser Gly Thr Leu Glu Gly Glu Glu Phe Val Gln Phe Tyr
     185                 190                 195

 aag gca ttg act aaa cgt gct gag gtg cag gaa ctg ttt gaa agt ttt      795
 Lys Ala Leu Thr Lys Arg Ala Glu Val Gln Glu Leu Phe Glu Ser Phe
 200                 205                 210                 215

 tca gct gat ggg cag aag ctg act ctg ctg gaa ttt ttg gat ttc ctc      843
 Ser Ala Asp Gly Gln Lys Leu Thr Leu Leu Glu Phe Leu Asp Phe Leu
                 220                 225                 230

 caa gag gag cag aag gag aga gac tgc acc tct gag ctt gct ctg gaa      891
 Gln Glu Glu Gln Lys Glu Arg Asp Cys Thr Ser Glu Leu Ala Leu Glu
             235                 240                 245

 ctc att gac cgc tat gaa cct tca gac agt ggc aaa ctg cgg cat gtg      939
 Leu Ile Asp Arg Tyr Glu Pro Ser Asp Ser Gly Lys Leu Arg His Val
         250                 255                 260

 ctg agt atg gat ggc ttc ctc agc tac ctc tgc tct aag gat gga gac      987
 Leu Ser Met Asp Gly Phe Leu Ser Tyr Leu Cys Ser Lys Asp Gly Asp
     265                 270                 275

 atc ttc aac cca gcc tgc ctc ccc atc tat cag gat atg act caa ccc     1035
 Ile Phe Asn Pro Ala Cys Leu Pro Ile Tyr Gln Asp Met Thr Gln Pro
 280                 285                 290                 295

 ctg aac cac tac ttc atc tgc tct tct cat aac acc tac cta gtg ggg     1083
 Leu Asn His Tyr Phe Ile Cys Ser Ser His Asn Thr Tyr Leu Val Gly
                 300                 305                 310

 gac cag ctt tgc ggc cag agc agc gtc gag gga tat ata cgg tgc agt     1131
 Asp Gln Leu Cys Gly Gln Ser Ser Val Glu Gly Tyr Ile Arg Cys Ser
             315                 320                 325

 ggt ggt aga gaa ggg gtc caa ctc atg aga ggg acc atg tag aaaagtg     1180
 Gly Gly Arg Glu Gly Val Gln Leu Met Arg Gly Thr Met 
         330                 335                 340

 aggggagctg tcagtgtcta acagattggg acagtgttgt gggggtttag gggctgagga   1240

 gccctggata ccagagacac ttggaggaga tattgaagac tggtgggaga atggtaatga   1300

 aaccctatgg gtcaatggaa cttctctttc acaagctatg aaactctcct ggaactcaga   1360

 ggccctgaca gatttatatt taacaaatta ataaacagat tgttaaatgg aaggcaatag   1420

 agaataggag ttaaaaatat aggttctgga gtcagaccat ctgaaattat attctagctc   1480

 ctttacttgg                                                          1490




      <210> 354
      <211> 1249
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1188)

      <400> 354
  atg gat ctc tgt cag aaa aat gag act gac tta gaa aat gct gaa aat      48
  Met Asp Leu Cys Gln Lys Asn Glu Thr Asp Leu Glu Asn Ala Glu Asn
    1               5                  10                  15

 aat gaa att cag ttc aca gaa gaa aca gaa cca acc tat act tgt cca       96
 Asn Glu Ile Gln Phe Thr Glu Glu Thr Glu Pro Thr Tyr Thr Cys Pro
              20                  25                  30

 gat gga aaa agt gaa aaa aat cat gtt tat tgt ctt ctc gat gtc agt      144
 Asp Gly Lys Ser Glu Lys Asn His Val Tyr Cys Leu Leu Asp Val Ser
          35                  40                  45

 gac att acg ctt gaa caa gat gaa aaa gcc aaa gag ttt att att gga      192
 Asp Ile Thr Leu Glu Gln Asp Glu Lys Ala Lys Glu Phe Ile Ile Gly
      50                  55                  60

 act gga tgg gaa gag gca gtc caa ggg tgg gga agg act tct cca gct      240
 Thr Gly Trp Glu Glu Ala Val Gln Gly Trp Gly Arg Thr Ser Pro Ala
  65                  70                  75                  80

 gcc tgc atc tgg ccg agg aag ata cca aaa aag gcg agg gta ggg gaa      288
 Ala Cys Ile Trp Pro Arg Lys Ile Pro Lys Lys Ala Arg Val Gly Glu
                  85                  90                  95

 ggt gcc tgc agc gac tgc ttg gtg tgt gtt aac ctc tcc cac tgg agc      336
 Gly Ala Cys Ser Asp Cys Leu Val Cys Val Asn Leu Ser His Trp Ser
             100                 105                 110

 ctc cag acc aag cct cct act gag ggg ggc cca gag aag gat cag agc      384
 Leu Gln Thr Lys Pro Pro Thr Glu Gly Gly Pro Glu Lys Asp Gln Ser
         115                 120                 125

 agc ccc tcc cag act cag gca gcc ccc cag ggc ccc agc act gct tcc      432
 Ser Pro Ser Gln Thr Gln Ala Ala Pro Gln Gly Pro Ser Thr Ala Ser
     130                 135                 140

 agg gca att agc gac atc tgc ttt ccc acc tac ttt cga gca gag aaa      480
 Arg Ala Ile Ser Asp Ile Cys Phe Pro Thr Tyr Phe Arg Ala Glu Lys
 145                 150                 155                 160

 aaa agt ctg caa atc aag gag ttt att tgg tgc aac aaa gac tgg gcc      528
 Lys Ser Leu Gln Ile Lys Glu Phe Ile Trp Cys Asn Lys Asp Trp Ala
                 165                 170                 175

 atc ccc ggc act aat agg ggc aag gcc tct ggg aat ccc agt gga ggg      576
 Ile Pro Gly Thr Asn Arg Gly Lys Ala Ser Gly Asn Pro Ser Gly Gly
             180                 185                 190

 gcc cac aga ggg cta tcc atc cca ggc ccc ctg act tcc agg gcc ctc      624
 Ala His Arg Gly Leu Ser Ile Pro Gly Pro Leu Thr Ser Arg Ala Leu
         195                 200                 205

 cta gtt ctg cct ccc ctg aag gct tca ctt tca aat gct ttg gat gtt      672
 Leu Val Leu Pro Pro Leu Lys Ala Ser Leu Ser Asn Ala Leu Asp Val
     210                 215                 220

 ctg ggt aag aag agt aag aac tct ttc ttg cag tca gaa gag aag gtg      720
 Leu Gly Lys Lys Ser Lys Asn Ser Phe Leu Gln Ser Glu Glu Lys Val
 225                 230                 235                 240

 ctg gat gtg gaa aag gat ggg tgt gtg gct tat gca tat ggc ttg aaa      768
 Leu Asp Val Glu Lys Asp Gly Cys Val Ala Tyr Ala Tyr Gly Leu Lys
                 245                 250                 255

 aca gca gat ggg aaa ggt gaa aaa aga gcc agt gag ctg gcc aaa cac      816
 Thr Ala Asp Gly Lys Gly Glu Lys Arg Ala Ser Glu Leu Ala Lys His
             260                 265                 270

 cct atg gtc aac gac acg cca tcc tcc cct tcc cca gcg gcc cag ata      864
 Pro Met Val Asn Asp Thr Pro Ser Ser Pro Ser Pro Ala Ala Gln Ile
         275                 280                 285

 tcc ctg ctg acc gat ccg gag cag cgc tgc ctg cat tgg tcc ctc ctg      912
 Ser Leu Leu Thr Asp Pro Glu Gln Arg Cys Leu His Trp Ser Leu Leu
     290                 295                 300

 tct gag aaa aac ctg gcg tgc cct cca gac ccc agc aac gtt cgc tac      960
 Ser Glu Lys Asn Leu Ala Cys Pro Pro Asp Pro Ser Asn Val Arg Tyr
 305                 310                 315                 320

 ctt gct gcc ttg cag ctt ctg cag aaa cgg gga gtg caa agc tac aaa     1008
 Leu Ala Ala Leu Gln Leu Leu Gln Lys Arg Gly Val Gln Ser Tyr Lys
                 325                 330                 335

 tcc aaa ttc aaa gcc aag gag cca aga tct cct gtg atc acc cga aag     1056
 Ser Lys Phe Lys Ala Lys Glu Pro Arg Ser Pro Val Ile Thr Arg Lys
             340                 345                 350

 cat gtt ctc cca aag gcc aag cag gaa aac agg ccc caa atg ctg gag     1104
 His Val Leu Pro Lys Ala Lys Gln Glu Asn Arg Pro Gln Met Leu Glu
         355                 360                 365

 acc aaa gtt ttc cca aga cct gtc ttg ccg tct ctc aca gtg agc aga     1152
 Thr Lys Val Phe Pro Arg Pro Val Leu Pro Ser Leu Thr Val Ser Arg
     370                 375                 380

 gtt atc att cct gtc tct acc cac agg atc ctc tga gcgg tcgcggtaga     1202
 Val Ile Ile Pro Val Ser Thr His Arg Ile Leu 
 385                 390                 395

 acccctggga ataagcaccg tttgagatgc agccatcctt tctcttt                 1249




      <210> 355
      <211> 1128
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (196)..(1128)

      <400> 355
 catatatttt ttaaacattt attttagcgt taccaaattg tcttgaagca ttcatttaaa     60

 aacacaaaaa ctcactgcag ctgtctgaac acttttctac ttcaccaaag agtgccgaac    120

 aagttaaaat gaatctgttt ttaaacactt ctcctaaacc atgagcatta acttgatttc    180

 ctctgtcata gggat atg ggg gac aat ata aca tcc atc aca gag ttc ctc     231
                  Met Gly Asp Asn Ile Thr Ser Ile Thr Glu Phe Leu
                    1               5                  10

 cta ctg gga ttt ccc gtt ggc cca agg att cag atg ctc ctc ttt ggg      279
 Leu Leu Gly Phe Pro Val Gly Pro Arg Ile Gln Met Leu Leu Phe Gly
          15                  20                  25

 ctc ttc tcc ctg ttc tac gtc ttc acc ctg ctg ggg aac ggg acc ata      327
 Leu Phe Ser Leu Phe Tyr Val Phe Thr Leu Leu Gly Asn Gly Thr Ile
      30                  35                  40

 ctg ggg ctc atc tca ctg gac tcc aga ctg cac gcc ccc atg tac ttc      375
 Leu Gly Leu Ile Ser Leu Asp Ser Arg Leu His Ala Pro Met Tyr Phe
  45                  50                  55                  60

 ttc ctc tca cac ctg gcg gtc gtc gac atc gcc tac gcc tgc aac acg      423
 Phe Leu Ser His Leu Ala Val Val Asp Ile Ala Tyr Ala Cys Asn Thr
                  65                  70                  75

 gtg ccc cgg atg ctg gtg aac ctc ctg cat cca gcc aag ccc atc tcc      471
 Val Pro Arg Met Leu Val Asn Leu Leu His Pro Ala Lys Pro Ile Ser
              80                  85                  90

 ttt gcg ggc cgc atg atg cag acc ttt ctg ttt tcc act ttt gct gtc      519
 Phe Ala Gly Arg Met Met Gln Thr Phe Leu Phe Ser Thr Phe Ala Val
          95                 100                 105

 aca gaa tgt ctc ctc ctg gtg gtg atg tcc tat gat ctg tac gtg gcc      567
 Thr Glu Cys Leu Leu Leu Val Val Met Ser Tyr Asp Leu Tyr Val Ala
     110                 115                 120

 atc tgc cac ccc ctc cga tat ttg gcc atc atg acc tgg aga gtc tgc      615
 Ile Cys His Pro Leu Arg Tyr Leu Ala Ile Met Thr Trp Arg Val Cys
 125                 130                 135                 140

 atc acc ctc gcg gtg act tcc tgg acc act gga gtc ctt tta tcc ttg      663
 Ile Thr Leu Ala Val Thr Ser Trp Thr Thr Gly Val Leu Leu Ser Leu
                 145                 150                 155

 att cat ctt gtg tta ctt cta cct tta ccc ttc tgt agg ccc cag aaa      711
 Ile His Leu Val Leu Leu Leu Pro Leu Pro Phe Cys Arg Pro Gln Lys
             160                 165                 170

 att tat cac ttt ttt tgt gaa atc ttg gct gtt ctc aaa ctt gcc tgt      759
 Ile Tyr His Phe Phe Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys
         175                 180                 185

 gca gat acc cac atc aat gag aac atg gtc ttg gcc gga gca att tct      807
 Ala Asp Thr His Ile Asn Glu Asn Met Val Leu Ala Gly Ala Ile Ser
     190                 195                 200

 ggg ctg gtg gga ccc ttg tcc aca att gta gtt tca tat atg tgc atc      855
 Gly Leu Val Gly Pro Leu Ser Thr Ile Val Val Ser Tyr Met Cys Ile
 205                 210                 215                 220

 ctc tgt gct atc ctt cag atc caa tca agg gaa gtt cag agg aaa gcc      903
 Leu Cys Ala Ile Leu Gln Ile Gln Ser Arg Glu Val Gln Arg Lys Ala
                 225                 230                 235

 ttc cgc acc tgc ttc tcc cac ctc tgt gtg att gga ctc gtt tat ggc      951
 Phe Arg Thr Cys Phe Ser His Leu Cys Val Ile Gly Leu Val Tyr Gly
             240                 245                 250

 aca gcc att atc atg tat gtt gga ccc aga tat ggg aac ccc aag gag      999
 Thr Ala Ile Ile Met Tyr Val Gly Pro Arg Tyr Gly Asn Pro Lys Glu
         255                 260                 265

 cag aag aaa tat ctc ctg ctg ttt cac agc ctc ttt aat ccc atg ctc     1047
 Gln Lys Lys Tyr Leu Leu Leu Phe His Ser Leu Phe Asn Pro Met Leu
     270                 275                 280

 aat ccc ctt atc tgt agt ctt agg aac tca gaa gtg aag aat act ttg     1095
 Asn Pro Leu Ile Cys Ser Leu Arg Asn Ser Glu Val Lys Asn Thr Leu
 285                 290                 295                 300

 aag aga gtg ctg gga gta gaa agg gct tta tga                         1128
 Lys Arg Val Leu Gly Val Glu Arg Ala Leu 
                 305                 310





      <210> 356
      <211> 3135
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (372)..(2984)

      <400> 356
 ggaattcccg ggtcgacgat ttcgtgtgaa acgcgggggc gtggctaagg gagggaaggg     60

 taatttgggg gctcttgaga gatgagagaa acaacgactg gagggattaa gaagaactct    120

 taggagcagc ttggcctaaa ggctgtgtgg gacgtgcctg ctttgccttc gccttccacc    180

 atgatttctt tgaccttctc ccatcttcca gtcagaggct aaacccaggc gctctgctgc    240

 cagtcctgac agaccccgcc ctgaatgatc tctatgtgat ttccaccttc aagctgcaga    300

 ctaaaagttc agccaccatc ttcggtcttt actcttcaac tgacaacagt aaatattttg    360

 aatttactgt g atg gga cgc tta aac aaa gcc atc ctc cgt tac ctg aag     410
              Met Gly Arg Leu Asn Lys Ala Ile Leu Arg Tyr Leu Lys
                1               5                  10

 aac gat ggg aag gtg cat ttg gtg gtt ttc aac aac ctg cag ctg gca      458
 Asn Asp Gly Lys Val His Leu Val Val Phe Asn Asn Leu Gln Leu Ala
      15                  20                  25

 gac gga agg cgg cac agg atc ctc ctg agg ctg agc aat ttg cag cga      506
 Asp Gly Arg Arg His Arg Ile Leu Leu Arg Leu Ser Asn Leu Gln Arg
  30                  35                  40                  45

 ggg gcc ggc tcc cta gag ctc tac ctg gac tgc atc cag gtg gat tcc      554
 Gly Ala Gly Ser Leu Glu Leu Tyr Leu Asp Cys Ile Gln Val Asp Ser
                  50                  55                  60

 gtt cac aat ctc ccc agg gcc ttt gct ggc ccc tcc cag aaa cct gag      602
 Val His Asn Leu Pro Arg Ala Phe Ala Gly Pro Ser Gln Lys Pro Glu
              65                  70                  75

 acc att gaa ttg agg act ttc cag agg aag cca cag gac ttc ttg gaa      650
 Thr Ile Glu Leu Arg Thr Phe Gln Arg Lys Pro Gln Asp Phe Leu Glu
          80                  85                  90

 gag ctg aag ctg gtg gtg aga ggc tca ctg ttc cag gtg gcc agc ctg      698
 Glu Leu Lys Leu Val Val Arg Gly Ser Leu Phe Gln Val Ala Ser Leu
      95                 100                 105

 caa gac tgc ttc ctg cag cag agt gag cca ctg gct gcc aca ggc aca      746
 Gln Asp Cys Phe Leu Gln Gln Ser Glu Pro Leu Ala Ala Thr Gly Thr
 110                 115                 120                 125

 ggg gac ttt aac cgg cag ttc ttg ggt caa atg aca caa tta aac caa      794
 Gly Asp Phe Asn Arg Gln Phe Leu Gly Gln Met Thr Gln Leu Asn Gln
                 130                 135                 140

 ctc ctg gga gag gtg aag gac ctt ctg aga cag cag gtt aag gaa aca      842
 Leu Leu Gly Glu Val Lys Asp Leu Leu Arg Gln Gln Val Lys Glu Thr
             145                 150                 155

 tca ttt ttg cga aac acc ata gct gaa tgc cag gct tgc ggt cct ctc      890
 Ser Phe Leu Arg Asn Thr Ile Ala Glu Cys Gln Ala Cys Gly Pro Leu
         160                 165                 170

 aag ttt cag tct ccg acc cca agc acg gtg gtc gcc ccg gct ccc cct      938
 Lys Phe Gln Ser Pro Thr Pro Ser Thr Val Val Ala Pro Ala Pro Pro
     175                 180                 185

 gca ccg cca aca cgc cca cct cgt cgg tgt gac tcc aac cca tgt ttc      986
 Ala Pro Pro Thr Arg Pro Pro Arg Arg Cys Asp Ser Asn Pro Cys Phe
 190                 195                 200                 205

 cga ggt gtc caa tgt acc gac agt aga gat ggc ttc cag tgt ggg ccc     1034
 Arg Gly Val Gln Cys Thr Asp Ser Arg Asp Gly Phe Gln Cys Gly Pro
                 210                 215                 220

 tgc ccc gag ggc tac aca gga aac ggg atc acc tgt att gat gtt gat     1082
 Cys Pro Glu Gly Tyr Thr Gly Asn Gly Ile Thr Cys Ile Asp Val Asp
             225                 230                 235

 gag tgc aaa tac cat ccc tgc tac ccg ggc gtg cac tgc ata aat ttg     1130
 Glu Cys Lys Tyr His Pro Cys Tyr Pro Gly Val His Cys Ile Asn Leu
         240                 245                 250

 tct cct ggc ttc aga tgt gac gcc tgc cca gtg ggc ttc aca ggg ccc     1178
 Ser Pro Gly Phe Arg Cys Asp Ala Cys Pro Val Gly Phe Thr Gly Pro
     255                 260                 265

 atg gtg cag ggt gtt ggg atc agt ttt gcc aag tca aac aag cag gtc     1226
 Met Val Gln Gly Val Gly Ile Ser Phe Ala Lys Ser Asn Lys Gln Val
 270                 275                 280                 285

 tgc act gac att gat gag tgt cga aat gga gcg tgc gtt ccc aac tcg     1274
 Cys Thr Asp Ile Asp Glu Cys Arg Asn Gly Ala Cys Val Pro Asn Ser
                 290                 295                 300

 atc tgc gtt aat act ttg gga tct tac cgc tgt ggg cct tgt aag ccg     1322
 Ile Cys Val Asn Thr Leu Gly Ser Tyr Arg Cys Gly Pro Cys Lys Pro
             305                 310                 315

 ggg tat act ggt gat cag ata agg gga tgc aaa gcg gaa aga aac tgc     1370
 Gly Tyr Thr Gly Asp Gln Ile Arg Gly Cys Lys Ala Glu Arg Asn Cys
         320                 325                 330

 aga aac cca gag ctg aac cct tgc agt gtg aat gcc cag tgc att gaa     1418
 Arg Asn Pro Glu Leu Asn Pro Cys Ser Val Asn Ala Gln Cys Ile Glu
     335                 340                 345

 gag agg cag ggg gat gtg aca tgt gtg tgt gga gtc ggt tgg gct gga     1466
 Glu Arg Gln Gly Asp Val Thr Cys Val Cys Gly Val Gly Trp Ala Gly
 350                 355                 360                 365

 gat ggc tat atc tgt gga aag gat gtg gac atc gac agt tac ccc gac     1514
 Asp Gly Tyr Ile Cys Gly Lys Asp Val Asp Ile Asp Ser Tyr Pro Asp
                 370                 375                 380

 gaa gaa ctg cca tgc tct gcc agg aac tgt aaa aag gac aac tgc aaa     1562
 Glu Glu Leu Pro Cys Ser Ala Arg Asn Cys Lys Lys Asp Asn Cys Lys
             385                 390                 395

 tat gtg cca aat tct ggc caa gaa gat gca gac aga gat ggc att ggc     1610
 Tyr Val Pro Asn Ser Gly Gln Glu Asp Ala Asp Arg Asp Gly Ile Gly
         400                 405                 410

 gac gct tgt gac gag gat gct gac gga gat ggg atc ctg aat gag cag     1658
 Asp Ala Cys Asp Glu Asp Ala Asp Gly Asp Gly Ile Leu Asn Glu Gln
     415                 420                 425

 gat aac tgt gtc ctg att cat aat gtg gac caa agg aac agc gat aaa     1706
 Asp Asn Cys Val Leu Ile His Asn Val Asp Gln Arg Asn Ser Asp Lys
 430                 435                 440                 445

 gat atc ttt ggg gat gcc tgt gat aac tgc ctg agt gtc tta aat aac     1754
 Asp Ile Phe Gly Asp Ala Cys Asp Asn Cys Leu Ser Val Leu Asn Asn
                 450                 455                 460

 gac cag aaa gac acc gat ggg gat gga aga gga gat gcc tgt gat gat     1802
 Asp Gln Lys Asp Thr Asp Gly Asp Gly Arg Gly Asp Ala Cys Asp Asp
             465                 470                 475

 gac atg gat gga gat gga ata aaa aac att ctg gac aac tgc cca aaa     1850
 Asp Met Asp Gly Asp Gly Ile Lys Asn Ile Leu Asp Asn Cys Pro Lys
         480                 485                 490

 ttt ccc aat cgt gac caa cgg gac aag gat ggt gat ggt gtg ggg gat     1898
 Phe Pro Asn Arg Asp Gln Arg Asp Lys Asp Gly Asp Gly Val Gly Asp
     495                 500                 505

 gcc tgt gac agt tgt cct gat gtc agc aac cct aac cag tct gat gtg     1946
 Ala Cys Asp Ser Cys Pro Asp Val Ser Asn Pro Asn Gln Ser Asp Val
 510                 515                 520                 525

 gat aat gat ctg gtt ggg gac tcc tgt gac acc aat cag gac agt gat     1994
 Asp Asn Asp Leu Val Gly Asp Ser Cys Asp Thr Asn Gln Asp Ser Asp
                 530                 535                 540

 gga gat ggg cac cag gac agc aca gac aac tgc ccc acc gtc att aac     2042
 Gly Asp Gly His Gln Asp Ser Thr Asp Asn Cys Pro Thr Val Ile Asn
             545                 550                 555

 agt gcc cag ctg gac acc gat aag gat gga att ggt gac gag tgt gat     2090
 Ser Ala Gln Leu Asp Thr Asp Lys Asp Gly Ile Gly Asp Glu Cys Asp
         560                 565                 570

 gat gat gat gac aat gat ggt atc cca gac ctg gtg ccc cct gga cca     2138
 Asp Asp Asp Asp Asn Asp Gly Ile Pro Asp Leu Val Pro Pro Gly Pro
     575                 580                 585

 gac aac tgc cgg ctg gtc ccc aac cca gcc cag gag gat agc aac agc     2186
 Asp Asn Cys Arg Leu Val Pro Asn Pro Ala Gln Glu Asp Ser Asn Ser
 590                 595                 600                 605

 gac gga gtg gga gac atc tgt gag tct gac ttt gac cag gac cag gtc     2234
 Asp Gly Val Gly Asp Ile Cys Glu Ser Asp Phe Asp Gln Asp Gln Val
                 610                 615                 620

 atc gat cgg atc gac gtc tgc cca gag aac gca gag gtc acc ctg acc     2282
 Ile Asp Arg Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu Thr
             625                 630                 635

 gac ttc agg gct tac cag acc gtg gtc ctg gat cct gaa ggg gat gcc     2330
 Asp Phe Arg Ala Tyr Gln Thr Val Val Leu Asp Pro Glu Gly Asp Ala
         640                 645                 650

 cag atc gat ccc aac tgg gtg gtc ctg aac cag ggc atg gag att gta     2378
 Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Met Glu Ile Val
     655                 660                 665

 cag acc atg aac agt gat cct ggc ctg gca gtg ggg tac aca gct ttt     2426
 Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe
 670                 675                 680                 685

 aat gga gtt gac ttc gaa ggg acc ttc cat gtg aat acc cag aca gat     2474
 Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Gln Thr Asp
                 690                 695                 700

 gat gac tat gca ggc ttt atc ttt ggc tac caa gat agc tcc agc ttc     2522
 Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser Phe
             705                 710                 715

 tac gtg gtc atg tgg aag cag acg gag cag aca tat tgg caa gcc acc     2570
 Tyr Val Val Met Trp Lys Gln Thr Glu Gln Thr Tyr Trp Gln Ala Thr
         720                 725                 730

 cca ttc cga gca gtt gca gaa cct ggc att cag ctc aag gct gtg aag     2618
 Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys
     735                 740                 745

 tct aag aca ggt cca ggg gag cat ctc cgg aac tcc ctg tgg cac acg     2666
 Ser Lys Thr Gly Pro Gly Glu His Leu Arg Asn Ser Leu Trp His Thr
 750                 755                 760                 765

 ggg gac acc agt gac cag gtc agg ctg ctg tgg aag gac tcc agg aat     2714
 Gly Asp Thr Ser Asp Gln Val Arg Leu Leu Trp Lys Asp Ser Arg Asn
                 770                 775                 780

 gtg ggc tgg aag gac aag gtg tcc tac cgc tgg ttc cta cag cac agg     2762
 Val Gly Trp Lys Asp Lys Val Ser Tyr Arg Trp Phe Leu Gln His Arg
             785                 790                 795

 ccc cag gtg ggc tac atc agg gta cga ttt tat gaa ggc tct gag ttg     2810
 Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Ser Glu Leu
         800                 805                 810

 gtg gct gac tct ggc gtc acc ata gac acc aca atg cgt gga ggc cga     2858
 Val Ala Asp Ser Gly Val Thr Ile Asp Thr Thr Met Arg Gly Gly Arg
     815                 820                 825

 ctt ggc gtt ttc tgc ttc tct caa gaa aac atc atc tgg tcc aac ctc     2906
 Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ser Asn Leu
 830                 835                 840                 845

 aag tat cgc tgc aat gac acc atc cct gag gac ttc caa gag ttt caa     2954
 Lys Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Phe Gln Glu Phe Gln
                 850                 855                 860

 acc cag aat ttc gac cgc ttc gat aat taa a ccaaggaagc aatctgtaac     3005
 Thr Gln Asn Phe Asp Arg Phe Asp Asn 
             865                 870

 tgcttttcgg aacactaaaa ccatatatat tttaacttca attttcttta gcttttacca   3065

 acccaaatat atcaaaacgt tttatgtgaa tgtggcaata aaggagaaga gatcattttt   3125

 aaaaaaaaaa                                                          3135




      <210> 357
      <211> 823
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (217)..(612)

      <400> 357
 ataaatgcta ggagcagcag ctctatggtt atgaggtggg gagaacggaa tgacgtcatc     60

 gcttgggagc tgctgcagga tggagtggaa agctgctgct gatggcattg tttttgtggc    120

 agcaagctga atgacagatc ctcactacaa agatacccct ttggcccccg tgtaggcctc    180

 cttggttcgg gtgtttcacc atgccagcac agcgcc  atg agt cct gga tgc atg     234
                                          Met Ser Pro Gly Cys Met
                                            1               5

 ctg ctg ttt gtg ttt ggc ttt gtt ggc ggg gcg gtg gtc att aat tct      282
 Leu Leu Phe Val Phe Gly Phe Val Gly Gly Ala Val Val Ile Asn Ser
              10                  15                  20

 gct atc tta gta tct ctc tct gtt ttg ctg ctt gtg cac ttt tct att      330
 Ala Ile Leu Val Ser Leu Ser Val Leu Leu Leu Val His Phe Ser Ile
          25                  30                  35

 tct acc ggt gtg cca gct ctg acg cag aac cta cca agg ata ctc aga      378
 Ser Thr Gly Val Pro Ala Leu Thr Gln Asn Leu Pro Arg Ile Leu Arg
      40                  45                  50

 aaa gaa cgc cct ata tca tta gga att ttc cca tta cct gct gga gat      426
 Lys Glu Arg Pro Ile Ser Leu Gly Ile Phe Pro Leu Pro Ala Gly Asp
  55                  60                  65                  70

 gga ttg ctt aca cct gat gct cag aaa gga gga gag acc cct gga tct      474
 Gly Leu Leu Thr Pro Asp Ala Gln Lys Gly Gly Glu Thr Pro Gly Ser
                  75                  80                  85

 gag caa tgg aaa ttt cag gaa tta agt caa cca cgt tct cat acc agc      522
 Glu Gln Trp Lys Phe Gln Glu Leu Ser Gln Pro Arg Ser His Thr Ser
              90                  95                 100

 ctg aag gtc agc aat agt cct gaa cct cag aag gct gta gaa cag gag      570
 Leu Lys Val Ser Asn Ser Pro Glu Pro Gln Lys Ala Val Glu Gln Glu
         105                 110                 115

 gtg aga atg gtg ctt ctt aac att ttg caa aaa gta tac taa agtgatt      619
 Val Arg Met Val Leu Leu Asn Ile Leu Gln Lys Val Tyr 
     120                 125                 130

 aactattgat tacttcctca actgctattc tcaagacatc agatgctcag cttggaagac    679

 tattgttgta attcactgaa atataaaaga aaattatttc cactgtagtg gttgtcaggg    739

 ctttactgca atctgtaatt tattccttcc ccaaagtaag catttttaaa taaaggaaag    799

 aaaatataag taaaaaaaaa aaaa                                           823




      <210> 358
      <211> 1738
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (77)..(1738)

      <400> 358
 tctcgcgaga agggcggcgg ccctgggttc tgggacaggt gacccggcgg cggggcgagg     60

 cagctggcgg cgtcgc    atg gag ggc tct ggg ggc ggt gcg ggc gag cgg     109
                      Met Glu Gly Ser Gly Gly Gly Ala Gly Glu Arg
                        1               5                  10

 gcg ccg ctg ctg ggc gcg cgg cgg gcg gcg gcg gcc gcg gcg gcg gct      157
 Ala Pro Leu Leu Gly Ala Arg Arg Ala Ala Ala Ala Ala Ala Ala Ala
              15                  20                  25

 ggg gcg ttc gcg ggc cgg cgc gcg gcg tgc ggg gcc gtg ctg ctg acg      205
 Gly Ala Phe Ala Gly Arg Arg Ala Ala Cys Gly Ala Val Leu Leu Thr
          30                  35                  40

 gag ctg ctg gag cgc gcc gct ttc tac ggc atc acg tcc aac ctg gtg      253
 Glu Leu Leu Glu Arg Ala Ala Phe Tyr Gly Ile Thr Ser Asn Leu Val
      45                  50                  55

 cta ttc ctg aac ggg gcg ccg ttc tgc tgg gag ggc gcg cag gcc agc      301
 Leu Phe Leu Asn Gly Ala Pro Phe Cys Trp Glu Gly Ala Gln Ala Ser
  60                  65                  70                  75

 gag gcg ctg ctg ctc ttc atg ggc ctc acc tac ctg ggc tcg ccg ttc      349
 Glu Ala Leu Leu Leu Phe Met Gly Leu Thr Tyr Leu Gly Ser Pro Phe
                  80                  85                  90

 gga ggc tgg ctg gcc gac gcg cgg ctg ggc cgg gcg cgc gcc atc ctg      397
 Gly Gly Trp Leu Ala Asp Ala Arg Leu Gly Arg Ala Arg Ala Ile Leu
              95                 100                 105

 ctg agc ctg gcg ctc tac ctg ctg ggc atg ctg gcc ttc ccg ctg ctg      445
 Leu Ser Leu Ala Leu Tyr Leu Leu Gly Met Leu Ala Phe Pro Leu Leu
         110                 115                 120

 gcc gcg ccc gcc acg cga gcc gcg ctc tgc ggt tcc gcg cgc ctg ctc      493
 Ala Ala Pro Ala Thr Arg Ala Ala Leu Cys Gly Ser Ala Arg Leu Leu
     125                 130                 135

 aac tgc acg gcg cct ggt ccc gac gcc gcc gcc cgc tgc tgc tca ccg      541
 Asn Cys Thr Ala Pro Gly Pro Asp Ala Ala Ala Arg Cys Cys Ser Pro
 140                 145                 150                 155

 gcc acc ttc gcg ggg ctg gtg ctg gtg ggc ctg ggc gtg gcc acc gtc      589
 Ala Thr Phe Ala Gly Leu Val Leu Val Gly Leu Gly Val Ala Thr Val
                 160                 165                 170

 aag gcc aac atc acg ccc ttc ggc gcc gac cag gtt aaa gat cga ggt      637
 Lys Ala Asn Ile Thr Pro Phe Gly Ala Asp Gln Val Lys Asp Arg Gly
             175                 180                 185

 ccg gaa gcc act agg aga ttt ttt aat tgg ttt tat tgg agc att aac      685
 Pro Glu Ala Thr Arg Arg Phe Phe Asn Trp Phe Tyr Trp Ser Ile Asn
         190                 195                 200

 ctg gga gcg atc ctg tcg tta ggt ggc att gcc tat att cag cag aac      733
 Leu Gly Ala Ile Leu Ser Leu Gly Gly Ile Ala Tyr Ile Gln Gln Asn
     205                 210                 215

 gtc agc ttt gtc act ggt tat gcg atc ccc act gtc tgc gtc ggc ctt      781
 Val Ser Phe Val Thr Gly Tyr Ala Ile Pro Thr Val Cys Val Gly Leu
 220                 225                 230                 235

 gct ttt gtg gtc ttc ctc tgt ggc cag agc gtt ttc atc acc aag cct      829
 Ala Phe Val Val Phe Leu Cys Gly Gln Ser Val Phe Ile Thr Lys Pro
                 240                 245                 250

 cct gat ggc agt gcc ttc acc gac atg ttc aag ata ctg acg tat tcc      877
 Pro Asp Gly Ser Ala Phe Thr Asp Met Phe Lys Ile Leu Thr Tyr Ser
             255                 260                 265

 tgc tgt tcc cag aag cga agt gga gag cgc cag agt aat ggt gaa ggc      925
 Cys Cys Ser Gln Lys Arg Ser Gly Glu Arg Gln Ser Asn Gly Glu Gly
         270                 275                 280

 att gga gtc ttt cag caa tct tct aaa caa agt ctg ttt gat tca tgt      973
 Ile Gly Val Phe Gln Gln Ser Ser Lys Gln Ser Leu Phe Asp Ser Cys
     285                 290                 295

 aag atg tct cat ggt ggg cca ttt aca gaa gag aaa gtg gaa gat gtg     1021
 Lys Met Ser His Gly Gly Pro Phe Thr Glu Glu Lys Val Glu Asp Val
 300                 305                 310                 315

 aaa gct ctg gtc aag att gtc cct gtt ttc ttg gct ttg ata cct tac     1069
 Lys Ala Leu Val Lys Ile Val Pro Val Phe Leu Ala Leu Ile Pro Tyr
                 320                 325                 330

 tgg aca gtg tat ttc caa ctc cct gca gcc tgg ctg acc atg ttt gat     1117
 Trp Thr Val Tyr Phe Gln Leu Pro Ala Ala Trp Leu Thr Met Phe Asp
             335                 340                 345

 gct gtg ctc atc ctc ctg ctc atc cct ctg aag gac aaa ctg gtc gat     1165
 Ala Val Leu Ile Leu Leu Leu Ile Pro Leu Lys Asp Lys Leu Val Asp
         350                 355                 360

 ccc att ttg aga aga cat ggc ctg ctc cca tcc tcc ctg aag agg atc     1213
 Pro Ile Leu Arg Arg His Gly Leu Leu Pro Ser Ser Leu Lys Arg Ile
     365                 370                 375

 gcc gtg ggc atg ttc ttt gtc atg tgc tcg gcc ttt gct gca gaa gga     1261
 Ala Val Gly Met Phe Phe Val Met Cys Ser Ala Phe Ala Ala Glu Gly
 380                 385                 390                 395

 att ttg gag agt aaa agg ctg aac ctt gtt aaa gag aaa acc att aat     1309
 Ile Leu Glu Ser Lys Arg Leu Asn Leu Val Lys Glu Lys Thr Ile Asn
                 400                 405                 410

 cag acc atc ggc aac gtc gtc tac cat gct gcc gat ctg tcg ctg tgg     1357
 Gln Thr Ile Gly Asn Val Val Tyr His Ala Ala Asp Leu Ser Leu Trp
             415                 420                 425

 tgg cag gtg ccg cag tac ttg ctg att ggg atc agc gag atc ttt gca     1405
 Trp Gln Val Pro Gln Tyr Leu Leu Ile Gly Ile Ser Glu Ile Phe Ala
         430                 435                 440

 agt atc gca ggc ctg gaa ttt gca tac tca gct gcc ccc aag tcc atg     1453
 Ser Ile Ala Gly Leu Glu Phe Ala Tyr Ser Ala Ala Pro Lys Ser Met
     445                 450                 455

 cag agt gcc ata atg ggc ttg ttc ttt ttc ttc tct ggc gtc ggg tcg     1501
 Gln Ser Ala Ile Met Gly Leu Phe Phe Phe Phe Ser Gly Val Gly Ser
 460                 465                 470                 475

 ttc gtg ggt tct gga ctg ctg gca ctg gtg tct atc aaa gcc atc gga     1549
 Phe Val Gly Ser Gly Leu Leu Ala Leu Val Ser Ile Lys Ala Ile Gly
                 480                 485                 490

 tgg atg agc agt cac aca gac ttt ggg ggt aat att aac ggc tgc tat     1597
 Trp Met Ser Ser His Thr Asp Phe Gly Gly Asn Ile Asn Gly Cys Tyr
             495                 500                 505

 ttg aac tat tac ttt ttt ctt ctg gct gct att caa gga gct acc ctc     1645
 Leu Asn Tyr Tyr Phe Phe Leu Leu Ala Ala Ile Gln Gly Ala Thr Leu
         510                 515                 520

 ctg ctt ttc ctc att att tct gtg aaa tat gac cat cat cga gac cat     1693
 Leu Leu Phe Leu Ile Ile Ser Val Lys Tyr Asp His His Arg Asp His
     525                 530                 535

 cag cga tca aga gcc aat ggc gtg ccc acc agc agg agg gcc tga         1738
 Gln Arg Ser Arg Ala Asn Gly Val Pro Thr Ser Arg Arg Ala 
 540                 545                 550





      <210> 359
      <211> 6277
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (230)..(3436)

      <400> 359
 tacggctgcg agaagacgac agaagggggc gggggaagga gcatctcagg aaaggggtcc     60

 ccggactctg gggctctcag cacctgcggt cgcaaaccaa cctcatgccc tgactttacc    120

 aggcgtcggg actctgactt aaccggggaa tgagggactt ggtctggcgg cagatcacaa    180

 tgaggaccta gggcatctgt ctgctgacgc cccctggcct gcagtgacc    atg gcc     235
                                                          Met Ala
                                                            1

 ccc cgc aag agg agc cac cat ggc ctg ggc ttc ctg tgc tgc ttc ggg      283
 Pro Arg Lys Arg Ser His His Gly Leu Gly Phe Leu Cys Cys Phe Gly
           5                  10                  15

 ggc agt gac atc ccc gaa atc aac ctc cgg gac aac cac cct ctg cag      331
 Gly Ser Asp Ile Pro Glu Ile Asn Leu Arg Asp Asn His Pro Leu Gln
      20                  25                  30

 ttc atg gag ttc tcc agc ccc atc ccg aac gca gag gag ctc aac atc      379
 Phe Met Glu Phe Ser Ser Pro Ile Pro Asn Ala Glu Glu Leu Asn Ile
  35                  40                  45                  50

 cgc ttt gca gag ctg gtg gat gaa ttg gat ctc act gac aaa aac cga      427
 Arg Phe Ala Glu Leu Val Asp Glu Leu Asp Leu Thr Asp Lys Asn Arg
                  55                  60                  65

 gag gct atg ttt gca ctg ccc cct gag aag aaa tgg cag atc tac tgc      475
 Glu Ala Met Phe Ala Leu Pro Pro Glu Lys Lys Trp Gln Ile Tyr Cys
              70                  75                  80

 agc aag aag aag gag cag gag gac ccc aac aag ctg gca acc agc tgg      523
 Ser Lys Lys Lys Glu Gln Glu Asp Pro Asn Lys Leu Ala Thr Ser Trp
          85                  90                  95

 cct gac tat tac atc gac cgc atc aat tcc atg gct gcg atg cag agt      571
 Pro Asp Tyr Tyr Ile Asp Arg Ile Asn Ser Met Ala Ala Met Gln Ser
     100                 105                 110

 ctg tac gcg ttt gat gag gag gag acg gag atg agg aac caa gtc gtg      619
 Leu Tyr Ala Phe Asp Glu Glu Glu Thr Glu Met Arg Asn Gln Val Val
 115                 120                 125                 130

 gaa gac ctg aag aca gcc ctc cgg aca cag cct atg agg ttt gtg acc      667
 Glu Asp Leu Lys Thr Ala Leu Arg Thr Gln Pro Met Arg Phe Val Thr
                 135                 140                 145

 cgc ttc att gag ctg gag ggc ttg acc tgt ctg cta aat ttc ctc cgg      715
 Arg Phe Ile Glu Leu Glu Gly Leu Thr Cys Leu Leu Asn Phe Leu Arg
             150                 155                 160

 agc atg gac cac gcc acc tgt gag agc cgc atc cac acc tca ctc att      763
 Ser Met Asp His Ala Thr Cys Glu Ser Arg Ile His Thr Ser Leu Ile
         165                 170                 175

 ggc tgc atc aaa gca ttg atg aac aac tcc cag ggg cgg gca cat gtg      811
 Gly Cys Ile Lys Ala Leu Met Asn Asn Ser Gln Gly Arg Ala His Val
     180                 185                 190

 ctg gca cag cct gag gcc att agt acc ata gcc cag agc cta cgc aca      859
 Leu Ala Gln Pro Glu Ala Ile Ser Thr Ile Ala Gln Ser Leu Arg Thr
 195                 200                 205                 210

 gag aac agc aag acc aag gtg gct gtg ctg gag atc ctg ggt gct gtg      907
 Glu Asn Ser Lys Thr Lys Val Ala Val Leu Glu Ile Leu Gly Ala Val
                 215                 220                 225

 tgc ctc gtg cct ggt ggc cac aag aag gtg ctg cag gcc atg ctg cac      955
 Cys Leu Val Pro Gly Gly His Lys Lys Val Leu Gln Ala Met Leu His
             230                 235                 240

 tac cag gtg tat gca gca gag cga acc cgc ttc cag acc ctg ctg aac     1003
 Tyr Gln Val Tyr Ala Ala Glu Arg Thr Arg Phe Gln Thr Leu Leu Asn
         245                 250                 255

 gag cta gac cga agt ctg ggc cgg tac cgg gat gaa gtg aat ctg aaa     1051
 Glu Leu Asp Arg Ser Leu Gly Arg Tyr Arg Asp Glu Val Asn Leu Lys
     260                 265                 270

 aca gcc atc atg tcc ttc atc aat gct gtc ctc aat gct gga gct gga     1099
 Thr Ala Ile Met Ser Phe Ile Asn Ala Val Leu Asn Ala Gly Ala Gly
 275                 280                 285                 290

 gag gat aat ctg gag ttc cgc cta cat cta cgg tat gaa ttc ctg atg     1147
 Glu Asp Asn Leu Glu Phe Arg Leu His Leu Arg Tyr Glu Phe Leu Met
                 295                 300                 305

 ctg ggt ata cag cct gtg att gac aag ctc cgg caa cat gaa aat gcc     1195
 Leu Gly Ile Gln Pro Val Ile Asp Lys Leu Arg Gln His Glu Asn Ala
             310                 315                 320

 atc ctg gac aaa cat tta gac ttc ttc gag atg gtg cgg aat gag gat     1243
 Ile Leu Asp Lys His Leu Asp Phe Phe Glu Met Val Arg Asn Glu Asp
         325                 330                 335

 gac ctg gag cta gcc agg agg ttt gac atg gtc cac atc gac acc aag     1291
 Asp Leu Glu Leu Ala Arg Arg Phe Asp Met Val His Ile Asp Thr Lys
     340                 345                 350

 agt gct tcc cag atg ttt gag ttg atc cac aag aag ctg aag tac acg     1339
 Ser Ala Ser Gln Met Phe Glu Leu Ile His Lys Lys Leu Lys Tyr Thr
 355                 360                 365                 370

 gag gcc tac ccc tgc ctg ctc tct gtg ctg cac cac tgc ctg cag atg     1387
 Glu Ala Tyr Pro Cys Leu Leu Ser Val Leu His His Cys Leu Gln Met
                 375                 380                 385

 ccc tac aaa cgg aac ggt ggc tac ttc cag cag tgg cag ctc ctg gac     1435
 Pro Tyr Lys Arg Asn Gly Gly Tyr Phe Gln Gln Trp Gln Leu Leu Asp
             390                 395                 400

 cgc atc ctc cag cag att gtc ctc cag gat gag cgg ggt gtg gac cct     1483
 Arg Ile Leu Gln Gln Ile Val Leu Gln Asp Glu Arg Gly Val Asp Pro
         405                 410                 415

 gac ctg gct ccc ttg gag aac ttc aat gtc aag aac atc gtc aac atg     1531
 Asp Leu Ala Pro Leu Glu Asn Phe Asn Val Lys Asn Ile Val Asn Met
     420                 425                 430

 ctc atc aac gag aat gaa gtg aaa cag tgg cga gac cag gca gag aag     1579
 Leu Ile Asn Glu Asn Glu Val Lys Gln Trp Arg Asp Gln Ala Glu Lys
 435                 440                 445                 450

 ttc cgg aaa gaa cac atg gag ctt gtg agc cgt ctg gag agg aag gag     1627
 Phe Arg Lys Glu His Met Glu Leu Val Ser Arg Leu Glu Arg Lys Glu
                 455                 460                 465

 cgg gaa tgc gag aca aag aca ttg gag aag gaa gag atg atg cgg acg     1675
 Arg Glu Cys Glu Thr Lys Thr Leu Glu Lys Glu Glu Met Met Arg Thr
             470                 475                 480

 ctg aac aaa atg aag gac aag ctg gcc cgg gag tcc cag gag ctg cgc     1723
 Leu Asn Lys Met Lys Asp Lys Leu Ala Arg Glu Ser Gln Glu Leu Arg
         485                 490                 495

 cag gct cgg gga caa gtg gca gag ctg gta gcc cag ctc agt gaa ctc     1771
 Gln Ala Arg Gly Gln Val Ala Glu Leu Val Ala Gln Leu Ser Glu Leu
     500                 505                 510

 tca aca ggc cct gta tct tcc cca cca ccc cct ggg ggc cca ctc acc     1819
 Ser Thr Gly Pro Val Ser Ser Pro Pro Pro Pro Gly Gly Pro Leu Thr
 515                 520                 525                 530

 ttg tct tcc tca atg aca acc aat gac ctg cct cca ccc cct cct cct     1867
 Leu Ser Ser Ser Met Thr Thr Asn Asp Leu Pro Pro Pro Pro Pro Pro
                 535                 540                 545

 ctg ccc ttt gcc tgt tgt ccc cct ccc cca cca cca ccc ctt cct ccc     1915
 Leu Pro Phe Ala Cys Cys Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro
             550                 555                 560

 ggg gga ccc ccg act ccc cca ggt gcc cca cct tgc ctc ggc atg ggc     1963
 Gly Gly Pro Pro Thr Pro Pro Gly Ala Pro Pro Cys Leu Gly Met Gly
         565                 570                 575

 ctg ccc ctc cct cag gac ccc tac ccc agc agt gac gtc cca ctc agg     2011
 Leu Pro Leu Pro Gln Asp Pro Tyr Pro Ser Ser Asp Val Pro Leu Arg
     580                 585                 590

 aaa aag cgt gtc ccc cag cct tct cac cca ctg aag tcc ttc aac tgg     2059
 Lys Lys Arg Val Pro Gln Pro Ser His Pro Leu Lys Ser Phe Asn Trp
 595                 600                 605                 610

 gtg aag ctg aat gag gag cgt gtc cct ggc acc gta tgg aat gag att     2107
 Val Lys Leu Asn Glu Glu Arg Val Pro Gly Thr Val Trp Asn Glu Ile
                 615                 620                 625

 gat gac atg cag gta ttt cgg atc ctg gac cta gag gat ttt gaa aag     2155
 Asp Asp Met Gln Val Phe Arg Ile Leu Asp Leu Glu Asp Phe Glu Lys
             630                 635                 640

 atg ttt tca gcc tac cag agg cac cag aaa gag ctg ggc tcc act gaa     2203
 Met Phe Ser Ala Tyr Gln Arg His Gln Lys Glu Leu Gly Ser Thr Glu
         645                 650                 655

 gac atc tac ctg gct tcc cgc aag gtc aaa gag ctg tcg gtc att gat     2251
 Asp Ile Tyr Leu Ala Ser Arg Lys Val Lys Glu Leu Ser Val Ile Asp
     660                 665                 670

 ggc cgg agg gcc caa aac tgc atc atc ctt ctt tcc aag ttg aag ctt     2299
 Gly Arg Arg Ala Gln Asn Cys Ile Ile Leu Leu Ser Lys Leu Lys Leu
 675                 680                 685                 690

 tct aac gag gag atc cgg cag gcc atc ttg aag atg gat gag cag gag     2347
 Ser Asn Glu Glu Ile Arg Gln Ala Ile Leu Lys Met Asp Glu Gln Glu
                 695                 700                 705

 gac ctt gct aag gac atg ctg gag cag ctc ctc aag ttc atc cca gag     2395
 Asp Leu Ala Lys Asp Met Leu Glu Gln Leu Leu Lys Phe Ile Pro Glu
             710                 715                 720

 aag agt gac att gac ctc ctg gag gag cac aag cat gaa att gag cgg     2443
 Lys Ser Asp Ile Asp Leu Leu Glu Glu His Lys His Glu Ile Glu Arg
         725                 730                 735

 atg gcc cgt gct gac cgc ttc ctc tat gaa atg agc agg att gac cac     2491
 Met Ala Arg Ala Asp Arg Phe Leu Tyr Glu Met Ser Arg Ile Asp His
     740                 745                 750

 tac cag cag cga ctg caa gcc ctc ttc ttc aag aag aaa ttc cag gag     2539
 Tyr Gln Gln Arg Leu Gln Ala Leu Phe Phe Lys Lys Lys Phe Gln Glu
 755                 760                 765                 770

 cgg ctg gct gag gca aag ccc aaa gtg gaa gcc atc ctg ttg gcc tcc     2587
 Arg Leu Ala Glu Ala Lys Pro Lys Val Glu Ala Ile Leu Leu Ala Ser
                 775                 780                 785

 cgg gag ctg gtc cgc agc aag cgt ctt aga cag atg cta gag gtc atc     2635
 Arg Glu Leu Val Arg Ser Lys Arg Leu Arg Gln Met Leu Glu Val Ile
             790                 795                 800

 cta gcc ata ggc aac ttc atg aac aaa ggg cag cgt ggg ggc gcc tac     2683
 Leu Ala Ile Gly Asn Phe Met Asn Lys Gly Gln Arg Gly Gly Ala Tyr
         805                 810                 815

 ggg ttc cgg gtg gcc agc ctc aac aag atc gct gac acc aag tcc agc     2731
 Gly Phe Arg Val Ala Ser Leu Asn Lys Ile Ala Asp Thr Lys Ser Ser
     820                 825                 830

 atc gac aga aac atc tct ctg ctc cat tac ctg atc atg atc ctg gag     2779
 Ile Asp Arg Asn Ile Ser Leu Leu His Tyr Leu Ile Met Ile Leu Glu
 835                 840                 845                 850

 aag cat ttt cct gat att cta aac atg cct tca gag ctg caa cat ctt     2827
 Lys His Phe Pro Asp Ile Leu Asn Met Pro Ser Glu Leu Gln His Leu
                 855                 860                 865

 cca gaa gcc gcc aaa gtc aac cta gca gaa ctg gag aag gag gtg ggc     2875
 Pro Glu Ala Ala Lys Val Asn Leu Ala Glu Leu Glu Lys Glu Val Gly
             870                 875                 880

 aac ctc agg agg ggc ctg aga gcg gtg gag gtg gag ctg gag tat cag     2923
 Asn Leu Arg Arg Gly Leu Arg Ala Val Glu Val Glu Leu Glu Tyr Gln
         885                 890                 895

 agg cgc cag gta cgg gag ccc agt gac aag ttt gtc cct gtc atg agc     2971
 Arg Arg Gln Val Arg Glu Pro Ser Asp Lys Phe Val Pro Val Met Ser
     900                 905                 910

 gac ttc atc acg gtg tcc agc ttc agc ttc tcc gag ctg gag gac cag     3019
 Asp Phe Ile Thr Val Ser Ser Phe Ser Phe Ser Glu Leu Glu Asp Gln
 915                 920                 925                 930

 cta aat gag gcc agg gac aag ttc gcc aag gcc ttg atg cac ttc ggg     3067
 Leu Asn Glu Ala Arg Asp Lys Phe Ala Lys Ala Leu Met His Phe Gly
                 935                 940                 945

 gag cat gac agc aag atg cag cca gac gaa ttc ttt ggc atc ttt gat     3115
 Glu His Asp Ser Lys Met Gln Pro Asp Glu Phe Phe Gly Ile Phe Asp
             950                 955                 960

 acc ttc ttg cag gcc ttc tca gag gcc cgg cag gat cta gag gcc atg     3163
 Thr Phe Leu Gln Ala Phe Ser Glu Ala Arg Gln Asp Leu Glu Ala Met
         965                 970                 975

 agg agg agg aag gag gag gag gag cgg cgg gcg cgc atg gaa gcc atg     3211
 Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Ala Arg Met Glu Ala Met
     980                 985                 990

 ctg aag gag cag agg gaa cgt gag cgg tgg cag cgg cag cgg aag gtc     3259
 Leu Lys Glu Gln Arg Glu Arg Glu Arg Trp Gln Arg Gln Arg Lys Val
 995                1000                1005                1010

 ctg gct gca ggc agc tcg ctg gag gag gga gga gag ttc gat gac ctg     3307
 Leu Ala Ala Gly Ser Ser Leu Glu Glu Gly Gly Glu Phe Asp Asp Leu
                1015                1020                1025

 gtg tcg gcc ctg cgc tct ggg gag gtc ttc gac aag gac tta tgc aag     3355
 Val Ser Ala Leu Arg Ser Gly Glu Val Phe Asp Lys Asp Leu Cys Lys
            1030                1035                1040

 ctc aag cgc agc cgc aag cga tca ggg agc cag gcc ctg gaa gtt acc     3403
 Leu Lys Arg Ser Arg Lys Arg Ser Gly Ser Gln Ala Leu Glu Val Thr
        1045                1050                1055

 cgg gag cgg gca ata aac cgg cta aat tat tga cctgggga actagccaca     3454
 Arg Glu Arg Ala Ile Asn Arg Leu Asn Tyr 
    1060                1065

 caggaggccg ggagacaggg actggtgaga atggggctga gtggaggagg tggtgatatt   3514

 taaaccattt ggtgcttggt ttagagcctt gggctgggtc ctgggatggg gggctgtgtg   3574

 tggctggacc aggtgtctcc ccacgcttac cttaaggggc tcctcttatc tccccttcac   3634

 atgattcctt ctgtgccctg gccccaggta ttattctgag gctgccttgg atggcctcag   3694

 gccaggtaac cccaggctga aggggccctg ctccccatcc cctaccatgg gcacccatgt   3754

 gctggcacag aacagttcca gatctagact ggagaggtcc acagccttgt ccagagttcc   3814

 tgtgtagcac ggggagcaat gatggaggga gcccctgaga gggaatctgg tgagggaatc   3874

 cagactccct tctctcaagg ggaggctcaa cagaacattg acctgggggc aaactttcct   3934

 cttgaatggg aacagaggag gcattatata ttctagttag atcagctctg gtaggttcca   3994

 gagaacagtc aatgttggaa ggatgatgca gggaccaaag ccatcaggac agagtagcag   4054

 tgtctgtttc ccatgtcaca agtcctctgg cctctccctg catgtcttaa gtatctttcc   4114

 cttccttctc taccctcacc tccatcctgt ctactaatcc acagtcctag aagactcacc   4174

 ttgggtttcc acagctatgg ctcactacca ggtgcttgat gaatctggcg aggggctcaa   4234

 gacagacctc atgcatcacc acacctcatg ccttttgggc atctcccatg tccccatctc   4294

 ctggacacct ggccattgtt gtgaagccag acagtgacct caaatgttgc cttggagtcc   4354

 cctacagccc ctcagcagag ggcagcactt gaatgcttag ctccatccca tagttctcta   4414

 cttcatataa attgctcagg ccctcccacc ccttctctaa cactagcttc aaggcagaag   4474

 ccacagcagc ctctgtccag cctgcaggtg gccacttgga accatgtgtc cactggcgtt   4534

 ggggagttgg ttcctgagag gtctgagggc cagagctgcc ctctacatta acatgctgtc   4594

 tctaagggtg gcccctcctc tcaggcgttc agatggtgcg aacagcagag caggcaaggg   4654

 aaactgggga gatggggatg gaggaggaag gctgatatcc tctggggagc acatcacctg   4714

 aaggtgccaa ggaggaaggc tgagaggggg gccaccccat ttctggtacc caatttggtt   4774

 cttcagccca acttgcaagg ggttccttct ggtcctccca tccactgcca ccttccattt   4834

 tgtccatctc atgctggcct tggtggatgg gatggctgta tctagacaaa atttttctaa   4894

 aactccatca aggctcttat tcaataccac gttccgagtt ggcctttcat cttctttgag   4954

 actggccctg cctaacctct accatcaatg agctcttggc ccttctgccc ttccctgtgt   5014

 ttctcacttt ccaacctaat ccctggctca gggttattgc cagtggagac tggtgagctg   5074

 ggcctactct cagctgccta tcttctgcct ttcacttgca tccaactcct ggggctggga   5134

 ccgtagtagc tgcggggggg aagaaacaca gggtcggtga gcccagcatg tgcgttggtt   5194

 tgagggggcg ggcggtgtgt gtgtgttctg gtgggaggga tctgagcaag tgcaagcctg   5254

 gctgacacag gtgtgaagag gccatcctgg aacccaggtg agggcaagat gaaggcttcc   5314

 aggcagaaca gctgcagaga gtttggctat atgcatctgc agccccaaga gctcccactg   5374

 caagacaagt gttggggaag atgggaggtt gtgggtgagg cctctaaagg tcctctccca   5434

 aactgaccag gctgatgtca acctaacccc ctcaggggca gggaacaggg gagggctcca   5494

 caagcgtgtc tggcattccc acccaccatg gaagactgga tacgcacctg gaaacaaaag   5554

 gactatggaa gctgttcaag atacatttga tcttcagaaa agcagaattt ggttcaactg   5614

 ttgacagagg acacaaatac gttgttccag agctcagcct tctcactcta aaagaaagat   5674

 atttttctat ttattttcta catctggcca gtggctctgg tgctagatgc cactgtagcc   5734

 agatctccaa cagtgccttg gaccatggac tcatactcaa ctgagtaaga aggggctggt   5794

 gcccagtcgg ggtggctgag ctggtcctta ataggttgtt tcttggtctt gctttcttca   5854

 tgccctcccc actgctcctg ccacctttag ataagtttct ctagctaatt ttgtggccaa   5914

 tgtaaaattc gtcatcaacc taacaaacac aaccttctca gcagcatttc tcccctgtga   5974

 tggaaataaa gtgtttaggg cagtgggagg agaaaattct ccaggtgaat ggggaagggt   6034

 ctgttccagc ctctccctac tcccatccca tttccaccaa ctggggaact gtgactatct   6094

 atctcccccg acttctacca gggatgcctt cacgccaagg ctgttctcac cagctgcctc   6154

 agatgacaaa tgaggctaat ggacataatc tacagtgtcc tttttcactt gcaccttttt   6214

 tataagaata tattgtaata ctaaaaaata ttaaattcat accatcccta ccaaaaaaaa   6274

 aaa                                                                 6277




      <210> 360
      <211> 2367
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(2064)

      <400> 360
 gtcgacccac gcgtccgtcc gttttcgcgt ggttcttttg caagctctgg attctctgga     60

 gtttgaatgt ttccagtatt ggaaccccac caagtaggac tgatcaggtc ttacaattct    120

 aaaacc   atg acc tgt ttt cag gaa tta gtg aca ttc agg gat gtg gcc     168
          Met Thr Cys Phe Gln Glu Leu Val Thr Phe Arg Asp Val Ala
            1               5                  10

 ata gac ttc tct cgg cag gag tgg gaa tac ctg gac cct aat cag agg      216
 Ile Asp Phe Ser Arg Gln Glu Trp Glu Tyr Leu Asp Pro Asn Gln Arg
  15                  20                  25                  30

 gac tta tac agg gat gtg atg ttg gag aac tat aga aac ctg gta tca      264
 Asp Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Val Ser
                  35                  40                  45

 ctg gga gga cat tcc att tct aaa cca gtt gtg gtt gat tta ctg gag      312
 Leu Gly Gly His Ser Ile Ser Lys Pro Val Val Val Asp Leu Leu Glu
              50                  55                  60

 cga gga aaa gag ccc tgg atg att ttg agg gaa gaa aca cag ttc aca      360
 Arg Gly Lys Glu Pro Trp Met Ile Leu Arg Glu Glu Thr Gln Phe Thr
          65                  70                  75

 gat ttg gat tta cag tgt gag ata atc agc tac ata gaa gta ccc act      408
 Asp Leu Asp Leu Gln Cys Glu Ile Ile Ser Tyr Ile Glu Val Pro Thr
      80                  85                  90

 tat gaa aca gat ata tcc tct aca caa ctt cag agc ata tat aag aga      456
 Tyr Glu Thr Asp Ile Ser Ser Thr Gln Leu Gln Ser Ile Tyr Lys Arg
  95                 100                 105                 110

 gag aaa ctc tat gaa tgt aag aaa tgt cag aag aaa ttt agt agt ggt      504
 Glu Lys Leu Tyr Glu Cys Lys Lys Cys Gln Lys Lys Phe Ser Ser Gly
                 115                 120                 125

 tat caa ctt att cta cat cac agg ttt cat gtc att gag aga ccc tat      552
 Tyr Gln Leu Ile Leu His His Arg Phe His Val Ile Glu Arg Pro Tyr
             130                 135                 140

 gaa tgc aaa gag tgt ggg aag aac ttt cgt agt ggc tat caa ctt act      600
 Glu Cys Lys Glu Cys Gly Lys Asn Phe Arg Ser Gly Tyr Gln Leu Thr
         145                 150                 155

 cta cat caa aga ttt cat act ggt gag aaa ccc tat gaa tgt aca gaa      648
 Leu His Gln Arg Phe His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu
     160                 165                 170

 tgt ggg aag aac ttt aga agt ggt tat cag ctg act gtg cat cag aga      696
 Cys Gly Lys Asn Phe Arg Ser Gly Tyr Gln Leu Thr Val His Gln Arg
 175                 180                 185                 190

 ttt cat act ggt gag aaa acc tat gaa tgt agg cag tgt ggg aag gcc      744
 Phe His Thr Gly Glu Lys Thr Tyr Glu Cys Arg Gln Cys Gly Lys Ala
                 195                 200                 205

 ttt ata tat gcc tca cac att gtt caa cat gag aga att cac act ggt      792
 Phe Ile Tyr Ala Ser His Ile Val Gln His Glu Arg Ile His Thr Gly
             210                 215                 220

 ggg aag ccg tat gaa tgt cag gag tgt ggg agg gcc ttt agt caa ggt      840
 Gly Lys Pro Tyr Glu Cys Gln Glu Cys Gly Arg Ala Phe Ser Gln Gly
         225                 230                 235

 gga cat ctt aga att cat cag aga gtt cat act ggc gaa aaa cca tat      888
 Gly His Leu Arg Ile His Gln Arg Val His Thr Gly Glu Lys Pro Tyr
     240                 245                 250

 aaa tgt aag gaa tgt ggg aag act ttt agt agg cgc tca aat ctt gtt      936
 Lys Cys Lys Glu Cys Gly Lys Thr Phe Ser Arg Arg Ser Asn Leu Val
 255                 260                 265                 270

 gaa cat ggg cag ttt cat act gat gag aag cca tac ata tgt gag aaa      984
 Glu His Gly Gln Phe His Thr Asp Glu Lys Pro Tyr Ile Cys Glu Lys
                 275                 280                 285

 tgt gga aag gcc ttt aga aga ggt cac cag ctt act gta cat cag aga     1032
 Cys Gly Lys Ala Phe Arg Arg Gly His Gln Leu Thr Val His Gln Arg
             290                 295                 300

 gtt cac act ggt aaa aag cca tat gag tgt aaa gaa tgt ggg aag ggc     1080
 Val His Thr Gly Lys Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Gly
         305                 310                 315

 tat acc act gcc tca tac ttt ctt cta cat cag aga att cat aaa ggt     1128
 Tyr Thr Thr Ala Ser Tyr Phe Leu Leu His Gln Arg Ile His Lys Gly
     320                 325                 330

 gga aaa ccc tat gaa tgt aag gag tgt aag aaa acc ttt act ttg tat     1176
 Gly Lys Pro Tyr Glu Cys Lys Glu Cys Lys Lys Thr Phe Thr Leu Tyr
 335                 340                 345                 350

 aga aat ctt act cgg cat cag aat att cat act ggt gag aaa ctt ttt     1224
 Arg Asn Leu Thr Arg His Gln Asn Ile His Thr Gly Glu Lys Leu Phe
                 355                 360                 365

 gaa tgc aag caa tgt ggg aag acc tat act act ggt tca aaa ctc ttt     1272
 Glu Cys Lys Gln Cys Gly Lys Thr Tyr Thr Thr Gly Ser Lys Leu Phe
             370                 375                 380

 caa cat cag aaa act cat act ggc gag aaa ccc tat gaa tgc aag gaa     1320
 Gln His Gln Lys Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu
         385                 390                 395

 tgc gga aag gcc ttt agc ttg tat ggc tac ctt aaa caa cat cag aaa     1368
 Cys Gly Lys Ala Phe Ser Leu Tyr Gly Tyr Leu Lys Gln His Gln Lys
     400                 405                 410

 att cat act ggc atg aaa cac ttt gaa tgt aag gag tgt aaa aaa acc     1416
 Ile His Thr Gly Met Lys His Phe Glu Cys Lys Glu Cys Lys Lys Thr
 415                 420                 425                 430

 ttt act ttg tat aga aat ctt act cga cat cag aat att cac act ggt     1464
 Phe Thr Leu Tyr Arg Asn Leu Thr Arg His Gln Asn Ile His Thr Gly
                 435                 440                 445

 aag aaa ctt ttt gaa tgt cag gaa tgt ggg aag gcc tat agt act ggc     1512
 Lys Lys Leu Phe Glu Cys Gln Glu Cys Gly Lys Ala Tyr Ser Thr Gly
             450                 455                 460

 tca aac ctt att caa cat cgg aaa act cat act ggt gag aaa ccc tat     1560
 Ser Asn Leu Ile Gln His Arg Lys Thr His Thr Gly Glu Lys Pro Tyr
         465                 470                 475

 aaa tgt aag gaa tgt ggc aag acc ttt agc ttg cat gga tat ctt aat     1608
 Lys Cys Lys Glu Cys Gly Lys Thr Phe Ser Leu His Gly Tyr Leu Asn
     480                 485                 490

 caa cat cag aaa att cat act ggt gtg aaa ccc tat gaa tgt aag gta     1656
 Gln His Gln Lys Ile His Thr Gly Val Lys Pro Tyr Glu Cys Lys Val
 495                 500                 505                 510

 tgt aga aaa acc ttt act ttc tat aga aat ctt act cta cat caa agt     1704
 Cys Arg Lys Thr Phe Thr Phe Tyr Arg Asn Leu Thr Leu His Gln Ser
                 515                 520                 525

 att cat act gat gag aaa cct ttt gaa tgt aag gaa tgt ggg aag acc     1752
 Ile His Thr Asp Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Thr
             530                 535                 540

 ttt aga cgt agt tca cac ctt act gca cat cag agc att cat gct gat     1800
 Phe Arg Arg Ser Ser His Leu Thr Ala His Gln Ser Ile His Ala Asp
         545                 550                 555

 aaa aaa ccc tat gaa tgt aaa gaa tgt gga aag gcc ttt aaa atg tat     1848
 Lys Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Lys Met Tyr
     560                 565                 570

 ggc tac ctt acc caa cat cag aaa att cat act ggt gga aaa cct tat     1896
 Gly Tyr Leu Thr Gln His Gln Lys Ile His Thr Gly Gly Lys Pro Tyr
 575                 580                 585                 590

 gaa tgt aaa gaa tgt ggg aag gcc ttc agt cgt gct tca aac ctt gtt     1944
 Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Arg Ala Ser Asn Leu Val
                 595                 600                 605

 caa cat gag aga att cat act ggt gag aaa ccc tat gtg tgt aag cag     1992
 Gln His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys Lys Gln
             610                 615                 620

 tgt ggg aaa acc ttc aga tat ggt tca gcc ctt aaa gcc cat cag aga     2040
 Cys Gly Lys Thr Phe Arg Tyr Gly Ser Ala Leu Lys Ala His Gln Arg
         625                 630                 635

 att cat agg agc ata aaa gtg taa gaccgtaaag agtatgagcg cgccattcat    2094
 Ile His Arg Ser Ile Lys Val 
     640                 645

 catcagacag cccacactgg tgagaaatga tggaatgtta gtcttatagg tatggcttta   2154

 gcaattgaga gagttcaaaa tgcagatctt gccacattag aaagcattca atgtcagtcc   2214

 tgttttaatg gaatatctga ctattcaatg gtaaattaag aaaaaaaaaa aaaaacggga   2274

 accccagttc cttcaggcct acaacatcca gggcatggga ttgttctttc aaaaaaacct   2334

 tcaataatta aggctgggag cgcgagagga tag                                2367




      <210> 361
      <211> 342
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(342)

      <400> 361
  atg gag ccc ccg atc cca cag agc gcc ccc ttg act ccc aac tca gtc      48
  Met Glu Pro Pro Ile Pro Gln Ser Ala Pro Leu Thr Pro Asn Ser Val
    1               5                  10                  15

 atg gtc cag ccc ctt ctt gac agc cgg atg tcc cac agc cgg ctc cag       96
 Met Val Gln Pro Leu Leu Asp Ser Arg Met Ser His Ser Arg Leu Gln
              20                  25                  30

 cac cca ctc acc atc cta ccc att gac cag gtg aag acc agc cat gtg      144
 His Pro Leu Thr Ile Leu Pro Ile Asp Gln Val Lys Thr Ser His Val
          35                  40                  45

 gag aat gac tac ata gac aac cct agc ctg gcc ctg acc acc ggc cca      192
 Glu Asn Asp Tyr Ile Asp Asn Pro Ser Leu Ala Leu Thr Thr Gly Pro
      50                  55                  60

 aag cgg acc cgg ggc ggg gcc cca aag ctg gcc cag cgt ggc tac gac      240
 Lys Arg Thr Arg Gly Gly Ala Pro Lys Leu Ala Gln Arg Gly Tyr Asp
  65                  70                  75                  80

 cgt ctg cgc cgc cct ggt tgc cgc tgc aag cac acg aac agc gtc atc      288
 Arg Leu Arg Arg Pro Gly Cys Arg Cys Lys His Thr Asn Ser Val Ile
                  85                  90                  95

 tgc aaa gca gcc agc ggg gat gcc aag acc agc agg ccc gac aag cct      336
 Cys Lys Ala Ala Ser Gly Asp Ala Lys Thr Ser Arg Pro Asp Lys Pro
             100                 105                 110

 ttc tga                                                              342
 Phe 






      <210> 362
      <211> 3800
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (432)..(2654)

      <400> 362
 ggtacagctc cgcaattccc gggtcgacga tttcgtagat caggaaaagc aatacttaaa     60

 ttcacttctg agccgaaact gggcattttg ggggatgggc atggcaaaca gcagtagagt    120

 tctttaggaa aaaattaggg acgttttcag cagctcccgc cacctactat gtccgggcta    180

 ctgcgggatc cacagaatgg aagctgcccg ccaacaggaa gaatgtctcc tccctctgca    240

 gggcttcctt tcccccatcg agggcccctg gggaccacag gtccccagcg ggtagggcgg    300

 aggcgtggcc ttgcgaaggt cagcggaggc cacccagagc tcacagcctc ctgccagcgc    360

 gctctctgtt tctctgcagc cccgaagctc gcgaatgtag caggcgcccc aagctcggtc    420

 ctcaagaagc c atg gcg gaa tcc agg ggc cgt ctg tac ctt tgg atg tgc     470
              Met Ala Glu Ser Arg Gly Arg Leu Tyr Leu Trp Met Cys
                1               5                  10

 ttg gct gct gcg ctg gca tct ttc ctg atg gga ttt atg gtg ggc tgg      518
 Leu Ala Ala Ala Leu Ala Ser Phe Leu Met Gly Phe Met Val Gly Trp
      15                  20                  25

 ttt att aag cct ctc aaa gaa aca acc act tct gtg cgc tat cat caa      566
 Phe Ile Lys Pro Leu Lys Glu Thr Thr Thr Ser Val Arg Tyr His Gln
  30                  35                  40                  45

 agt ata cgg tgg aaa ctg gta tcc gaa atg aaa gct gaa aac atc aaa      614
 Ser Ile Arg Trp Lys Leu Val Ser Glu Met Lys Ala Glu Asn Ile Lys
                  50                  55                  60

 tca ttt ctt cgt tct ttt aca aag ctt cct cat ctg gca gga aca gaa      662
 Ser Phe Leu Arg Ser Phe Thr Lys Leu Pro His Leu Ala Gly Thr Glu
              65                  70                  75

 caa aat ttc ttg ctt gcc aag aaa atc caa acc cag tgg aag aaa ttt      710
 Gln Asn Phe Leu Leu Ala Lys Lys Ile Gln Thr Gln Trp Lys Lys Phe
          80                  85                  90

 gga cta gat tca gcc aag ttg gtt cat tat gat gtc ctc tta tct tac      758
 Gly Leu Asp Ser Ala Lys Leu Val His Tyr Asp Val Leu Leu Ser Tyr
      95                 100                 105

 ccc aat gag aca aat gcc aac tat ata tcg att gtg gat gaa cat gaa      806
 Pro Asn Glu Thr Asn Ala Asn Tyr Ile Ser Ile Val Asp Glu His Glu
 110                 115                 120                 125

 act gag att ttc aaa aca tca tac ctt gaa cca cca cca gat ggc tat      854
 Thr Glu Ile Phe Lys Thr Ser Tyr Leu Glu Pro Pro Pro Asp Gly Tyr
                 130                 135                 140

 gag aat gtt aca aat att gtg cca cca tat aat gct ttc tca gcc caa      902
 Glu Asn Val Thr Asn Ile Val Pro Pro Tyr Asn Ala Phe Ser Ala Gln
             145                 150                 155

 ggc atg cca gag gga gat ctt gta tat gtg aac tat gct cgc act gaa      950
 Gly Met Pro Glu Gly Asp Leu Val Tyr Val Asn Tyr Ala Arg Thr Glu
         160                 165                 170

 gac ttt ttc aaa cta gaa aga gag atg ggc atc aac tgt act ggg aag      998
 Asp Phe Phe Lys Leu Glu Arg Glu Met Gly Ile Asn Cys Thr Gly Lys
     175                 180                 185

 att gtt att gca aga tat gga aaa atc ttc aga gga aat aaa gtt aaa     1046
 Ile Val Ile Ala Arg Tyr Gly Lys Ile Phe Arg Gly Asn Lys Val Lys
 190                 195                 200                 205

 aat gcc atg tta gca gga gcc ata gga atc atc ttg tac tca gat cca     1094
 Asn Ala Met Leu Ala Gly Ala Ile Gly Ile Ile Leu Tyr Ser Asp Pro
                 210                 215                 220

 gct gac tac ttt gct cct gag gta cag cca tat ccc aaa gga tgg aat     1142
 Ala Asp Tyr Phe Ala Pro Glu Val Gln Pro Tyr Pro Lys Gly Trp Asn
             225                 230                 235

 ctt cct gga act gca gcc cag aga gga aat gtg tta aat ttg aat ggt     1190
 Leu Pro Gly Thr Ala Ala Gln Arg Gly Asn Val Leu Asn Leu Asn Gly
         240                 245                 250

 gct ggt gac cca ctc act cca ggc tat cca gca aaa gaa tac act ttc     1238
 Ala Gly Asp Pro Leu Thr Pro Gly Tyr Pro Ala Lys Glu Tyr Thr Phe
     255                 260                 265

 aga ctt gat gtt gaa gaa gga gtg gga atc ccc cga ata cct gta cat     1286
 Arg Leu Asp Val Glu Glu Gly Val Gly Ile Pro Arg Ile Pro Val His
 270                 275                 280                 285

 ccc att gga tat aat gat gca gaa ata tta tta cgc tac ttg gga gga     1334
 Pro Ile Gly Tyr Asn Asp Ala Glu Ile Leu Leu Arg Tyr Leu Gly Gly
                 290                 295                 300

 att gct cca cca gat aag agt tgg aag gga gcc ctt aat gtg agt tat     1382
 Ile Ala Pro Pro Asp Lys Ser Trp Lys Gly Ala Leu Asn Val Ser Tyr
             305                 310                 315

 agt atc gga cct ggc ttt aca ggg agt gat tct ttc agg aag gtt aga     1430
 Ser Ile Gly Pro Gly Phe Thr Gly Ser Asp Ser Phe Arg Lys Val Arg
         320                 325                 330

 atg cat gtt tat aac atc aat aaa att aca agg att tac aat gta gtt     1478
 Met His Val Tyr Asn Ile Asn Lys Ile Thr Arg Ile Tyr Asn Val Val
     335                 340                 345

 gga act atc aga gga tct gtg gaa cct gac agg tat gtt att ctg gga     1526
 Gly Thr Ile Arg Gly Ser Val Glu Pro Asp Arg Tyr Val Ile Leu Gly
 350                 355                 360                 365

 ggt cac cgg gac tcc tgg gta ttt gga gct att gac cca acc agt ggg     1574
 Gly His Arg Asp Ser Trp Val Phe Gly Ala Ile Asp Pro Thr Ser Gly
                 370                 375                 380

 gtt gct gtt ttg caa gaa att gcc cgg agt ttt gga aaa ctg atg agt     1622
 Val Ala Val Leu Gln Glu Ile Ala Arg Ser Phe Gly Lys Leu Met Ser
             385                 390                 395

 aaa ggc tgg aga cct aga aga act atc att ttt gcc agc tgg gat gca     1670
 Lys Gly Trp Arg Pro Arg Arg Thr Ile Ile Phe Ala Ser Trp Asp Ala
         400                 405                 410

 gaa gaa ttt gga ctt ctg ggt tcc aca gaa tgg gct gag gag aat gtc     1718
 Glu Glu Phe Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu Glu Asn Val
     415                 420                 425

 aaa ata ctc cag gag aga agc att gct tat atc aac tcg gat tca tct     1766
 Lys Ile Leu Gln Glu Arg Ser Ile Ala Tyr Ile Asn Ser Asp Ser Ser
 430                 435                 440                 445

 ata gaa ggc aat tat act ctc aga gtt gac tgt act ccc ctt ctt tac     1814
 Ile Glu Gly Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro Leu Leu Tyr
                 450                 455                 460

 caa tta gtg tat aaa ctg aca aaa gag atc ccc agc cct gat gat ggg     1862
 Gln Leu Val Tyr Lys Leu Thr Lys Glu Ile Pro Ser Pro Asp Asp Gly
             465                 470                 475

 ttt gag agt aaa tca ctg tat gaa agc tgg ttg gaa aaa gac cct tca     1910
 Phe Glu Ser Lys Ser Leu Tyr Glu Ser Trp Leu Glu Lys Asp Pro Ser
         480                 485                 490

 cct gaa aat aaa aat ttg cct aga atc aat aag ctg gga tct gga agt     1958
 Pro Glu Asn Lys Asn Leu Pro Arg Ile Asn Lys Leu Gly Ser Gly Ser
     495                 500                 505

 gac ttt gaa gct tat ttt cag aga ctt gga att gct tca ggc aga gcc     2006
 Asp Phe Glu Ala Tyr Phe Gln Arg Leu Gly Ile Ala Ser Gly Arg Ala
 510                 515                 520                 525

 cgt tac act aag aat aag aaa aca gat aag tac agc agc tac cca gtg     2054
 Arg Tyr Thr Lys Asn Lys Lys Thr Asp Lys Tyr Ser Ser Tyr Pro Val
                 530                 535                 540

 tac cac aca att tat gag aca ttt gaa ttg gta gag aaa ttt tat gac     2102
 Tyr His Thr Ile Tyr Glu Thr Phe Glu Leu Val Glu Lys Phe Tyr Asp
             545                 550                 555

 ccc aca ttt aaa aaa caa ctt tct gtg gct caa tta cga gga gca ctg     2150
 Pro Thr Phe Lys Lys Gln Leu Ser Val Ala Gln Leu Arg Gly Ala Leu
         560                 565                 570

 gta tat gag ctt gtg gat tct aaa atc att cct ttt aat att caa gac     2198
 Val Tyr Glu Leu Val Asp Ser Lys Ile Ile Pro Phe Asn Ile Gln Asp
     575                 580                 585

 tat gca gaa gct ttg aaa aac tat gca gca agt atc tat aat cta tct     2246
 Tyr Ala Glu Ala Leu Lys Asn Tyr Ala Ala Ser Ile Tyr Asn Leu Ser
 590                 595                 600                 605

 aag aaa cat gat caa caa ttg aca gac cat gga gta tca ttt gac tcc     2294
 Lys Lys His Asp Gln Gln Leu Thr Asp His Gly Val Ser Phe Asp Ser
                 610                 615                 620

 tta ttt tct gct gtg aaa aac ttc tca gag gct gct tca gat ttt cat     2342
 Leu Phe Ser Ala Val Lys Asn Phe Ser Glu Ala Ala Ser Asp Phe His
             625                 630                 635

 aaa cga ctt ata caa gtt gat ctt aac aat ccc att gca gtg aga atg     2390
 Lys Arg Leu Ile Gln Val Asp Leu Asn Asn Pro Ile Ala Val Arg Met
         640                 645                 650

 atg aat gac caa ctg atg ctc ctg gaa aga gca ttc atc gat cct ctt     2438
 Met Asn Asp Gln Leu Met Leu Leu Glu Arg Ala Phe Ile Asp Pro Leu
     655                 660                 665

 ggt tta cca gga aag ctg ttc tat agg cac atc ata ttt gct cca agt     2486
 Gly Leu Pro Gly Lys Leu Phe Tyr Arg His Ile Ile Phe Ala Pro Ser
 670                 675                 680                 685

 agc cac aac aaa tat gct gga gaa tca ttt cct gga atc tat gat gct     2534
 Ser His Asn Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile Tyr Asp Ala
                 690                 695                 700

 atc ttt gat att gaa aat aaa gcc aac tct cgt ttg gcc tgg aaa gaa     2582
 Ile Phe Asp Ile Glu Asn Lys Ala Asn Ser Arg Leu Ala Trp Lys Glu
             705                 710                 715

 gta aag aaa cat att tct att gca gct ttt aca att caa gca gca gca     2630
 Val Lys Lys His Ile Ser Ile Ala Ala Phe Thr Ile Gln Ala Ala Ala
         720                 725                 730

 gga act ctg aaa gaa gta tta tag aaggtctcaa gtggctagcc attaaaggtg    2684
 Gly Thr Leu Lys Glu Val Leu 
     735                 740

 ttgctaaaag tctgaggata aaattcacct ttctgataac ttatgaagcc agggtgttct   2744

 aaactctttt catgtcatgt tttgattata ggctttggtc ttttcatctg caaagccttt   2804

 tttttttgct ctttaaaagt taataattat attagcaaag ggttaatcta atgaagtaaa   2864

 aaactcctgt gtggcagaaa gtaaaagaaa attccctaaa ttatagcaag gaacatgaat   2924

 tctcagacat tgtgagtgtg ggaatgtaaa atggtaaaat cacttttgaa aacagtttgg   2984

 cagtttccta taaagttaaa catacacttt tactttagga ctccagaatt ccacttctag   3044

 ttatttattc aagagaagga aaaacaatga tcacagcaat acttgtatgc atgttcattg   3104

 caacttaaaa gcgtaaaaac cccaaatgtc catccacaga cgaatgtata aactgtggta   3164

 tccattacac aatagactac ttactactca gcaataaaaa tgaagtaact ttcaataaat   3224

 gcaatattat tggcagacat tgttgaagga aaaaagccag acaaacaact acataaaata   3284

 tgtttctatt tagatgaagt ggcaaactaa tctgtagtgt taaaaattag attagtgatt   3344

 gcctgggcca agtggcaggt tggggaggat ggctgcaaag aagtatgagg aaactttctc   3404

 caatagatga gaattttccg tatcttgatc tgagtggcaa attgtaaact taaaatatat   3464

 ataaaattta ttgtatgaaa attaagcctc aataaatgtg attataaaaa acaagtctgc   3524

 aaggaaacca gaatcatata ccttctcttg tgaaatcacc atgaagtgtg aatggtcagg   3584

 aaaaagccag taatattcat acatttaata atttcagctc tactgaataa acatataagt   3644

 ctgatgggtg atgaaaatag ctactacaat cttcatattc taactcctat aaagactgta   3704

 tatcagaatc tgcaaacttt tatgcagatc ccagtgactc aattacatgt tcaactatga   3764

 ttaaagcttc aataaacttg gttgttcatc tacttc                             3800




      <210> 363
      <211> 1251
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (123)..(986)

      <400> 363
 cggcggtgct ggtggtgctc ggcggccgga gccggatcct gtagccgggt gtgggcccgt     60

 gtctgtccgt ccctccttcg gccccctctc ttgtcttccg gagtgtggct ggcggagctg    120

 gg   atg gcg gaa cga ggc ctg gag ccg tcg ccg gcc gcg gtg gcg gcg     167
      Met Ala Glu Arg Gly Leu Glu Pro Ser Pro Ala Ala Val Ala Ala
        1               5                  10                  15

 ctg ccg cct gaa gtg cgg gcg cag ctg gcg gag ctg gag ctg gag ctc      215
 Leu Pro Pro Glu Val Arg Ala Gln Leu Ala Glu Leu Glu Leu Glu Leu
                  20                  25                  30

 tcg gag ggg gac atc acc cag aag ggc tat gaa aag aaa agg tcc aaa      263
 Ser Glu Gly Asp Ile Thr Gln Lys Gly Tyr Glu Lys Lys Arg Ser Lys
              35                  40                  45

 ctc cta tct cct tac agc ccg cag aca caa gaa act gat tca gca gta      311
 Leu Leu Ser Pro Tyr Ser Pro Gln Thr Gln Glu Thr Asp Ser Ala Val
          50                  55                  60

 cag aaa gaa ctt aga aac cag aca cct gct cca tct gca gct caa act      359
 Gln Lys Glu Leu Arg Asn Gln Thr Pro Ala Pro Ser Ala Ala Gln Thr
      65                  70                  75

 tct gct ccc tct aag tac cac cga act cga tct ggg gga gcc agg gat      407
 Ser Ala Pro Ser Lys Tyr His Arg Thr Arg Ser Gly Gly Ala Arg Asp
  80                  85                  90                  95

 gaa cga tat cga tca gat atc cac aca gaa gca gtt cag gct gca ctg      455
 Glu Arg Tyr Arg Ser Asp Ile His Thr Glu Ala Val Gln Ala Ala Leu
                 100                 105                 110

 gca aag cat aaa gaa cag aag atg gct ttg ccc atg cca acc aaa agg      503
 Ala Lys His Lys Glu Gln Lys Met Ala Leu Pro Met Pro Thr Lys Arg
             115                 120                 125

 cga tcc aca ttt gtt cag tct cct gca gat gcc tgc aca cct cct gac      551
 Arg Ser Thr Phe Val Gln Ser Pro Ala Asp Ala Cys Thr Pro Pro Asp
         130                 135                 140

 aca tct tcg gcc tct gag gat gag ggc tct ctg aga cgc caa gct gcg      599
 Thr Ser Ser Ala Ser Glu Asp Glu Gly Ser Leu Arg Arg Gln Ala Ala
     145                 150                 155

 ctc tct gct gcc ttg caa cag agc tta cag aat gct gag tcc tgg atc      647
 Leu Ser Ala Ala Leu Gln Gln Ser Leu Gln Asn Ala Glu Ser Trp Ile
 160                 165                 170                 175

 aac cgt tca att cag gga tcg tcc act tct tca tcc gca tct tct acg      695
 Asn Arg Ser Ile Gln Gly Ser Ser Thr Ser Ser Ser Ala Ser Ser Thr
                 180                 185                 190

 ctg tcc cac gga gag gtc aaa gga acc agt ggg tct cta gct gat gta      743
 Leu Ser His Gly Glu Val Lys Gly Thr Ser Gly Ser Leu Ala Asp Val
             195                 200                 205

 ttt gcc aat act cga ata gag aat ttc tct gct cct cct gat gtc act      791
 Phe Ala Asn Thr Arg Ile Glu Asn Phe Ser Ala Pro Pro Asp Val Thr
         210                 215                 220

 aca act acc tct tcc tcc tca tca tct tcc tca att cgc cca gca aac      839
 Thr Thr Thr Ser Ser Ser Ser Ser Ser Ser Ser Ile Arg Pro Ala Asn
     225                 230                 235

 att gac ctg ccc ccc tcg ggg ata gtt aaa ggc atg cac aaa gga tcc      887
 Ile Asp Leu Pro Pro Ser Gly Ile Val Lys Gly Met His Lys Gly Ser
 240                 245                 250                 255

 aac agg tcc agc ctt atg gat aca gct gat ggt gtt cct gtc agt agc      935
 Asn Arg Ser Ser Leu Met Asp Thr Ala Asp Gly Val Pro Val Ser Ser
                 260                 265                 270

 aga gta tct aca aaa atc cag cag ctt ctg aac act ctg aaa cga ccc      983
 Arg Val Ser Thr Lys Ile Gln Gln Leu Leu Asn Thr Leu Lys Arg Pro
             275                 280                 285

 taa aggc ctcccttaga ggaaagcttt gtggatgact ctgaagaaat tctcggagta     1040
 


 cggcagccag accccaaaca ggcccaagcc ggagctacgg cagatgacgc ctctgaaagg   1100

 agagcctgta ggagtcatgc acgttactgc actcctgctc ttgagtctgc cctgacagcg   1160

 ctggggtatc actcaagcaa aatgctcctg ctcggactcg cactggacat tacaagggag   1220

 agccagttac agcacggaca atggaaagac g                                  1251




      <210> 364
      <211> 6377
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(5640)

      <400> 364
 attgaaagct gtacgcctgc aggatgagac ccgaattccc gggtcgacga tttcgtgaga     60

 atctcgatgc tggcctggag cagaaactga gctggaccac tggagcctcg ggtgcagggg    120

 gca  atg gca ctg cag ctc tgg gcc ctg acc ctg ctg ggc ctg ctg ggc     168
      Met Ala Leu Gln Leu Trp Ala Leu Thr Leu Leu Gly Leu Leu Gly
        1               5                  10                  15

 gca ggt gcc agc ctg agg ccc cgc aag ctg gac ttc ttc cgc agc gag      216
 Ala Gly Ala Ser Leu Arg Pro Arg Lys Leu Asp Phe Phe Arg Ser Glu
                  20                  25                  30

 aaa gag ctg aac cac ctg gct gtg gat gag gcc tca ggc gtg gtg tac      264
 Lys Glu Leu Asn His Leu Ala Val Asp Glu Ala Ser Gly Val Val Tyr
              35                  40                  45

 ctg ggg gcg gtg aat gcc ctc tac cag ctg gat gcg aag ctg cag ctg      312
 Leu Gly Ala Val Asn Ala Leu Tyr Gln Leu Asp Ala Lys Leu Gln Leu
          50                  55                  60

 gag cag cag gtg gcc acg ggc ccg gcc ctg gac aac aag aag tgc acg      360
 Glu Gln Gln Val Ala Thr Gly Pro Ala Leu Asp Asn Lys Lys Cys Thr
      65                  70                  75

 ccg ccc atc gag gcc agc cag tgc cat gag gct gag atg act gac aat      408
 Pro Pro Ile Glu Ala Ser Gln Cys His Glu Ala Glu Met Thr Asp Asn
  80                  85                  90                  95

 gtc aac cag ctg ctg ctg ctc gac cct ccc agg aag cgc ctg gtg gag      456
 Val Asn Gln Leu Leu Leu Leu Asp Pro Pro Arg Lys Arg Leu Val Glu
                 100                 105                 110

 tgc ggc agc ctc ttc aag ggc atc tgc gct ctg cgc gcc ctg agc aac      504
 Cys Gly Ser Leu Phe Lys Gly Ile Cys Ala Leu Arg Ala Leu Ser Asn
             115                 120                 125

 atc tcc ctc cgc ctg ttc tac gag gac ggc agc ggg gag aag tct ttc      552
 Ile Ser Leu Arg Leu Phe Tyr Glu Asp Gly Ser Gly Glu Lys Ser Phe
         130                 135                 140

 gtg gcc agc aat gat gag ggc gtg gcc aca gtg ggg ctg gtg agc tcc      600
 Val Ala Ser Asn Asp Glu Gly Val Ala Thr Val Gly Leu Val Ser Ser
     145                 150                 155

 acg ggt cct ggt ggt gac cgc gtg ctg ttt gtg ggc aaa ggc aat ggg      648
 Thr Gly Pro Gly Gly Asp Arg Val Leu Phe Val Gly Lys Gly Asn Gly
 160                 165                 170                 175

 cca cac gac aac ggc atc atc gtg agc act cgg ctg ttg gac cgg act      696
 Pro His Asp Asn Gly Ile Ile Val Ser Thr Arg Leu Leu Asp Arg Thr
                 180                 185                 190

 gac agc agg gag gcc ttt gaa gcc tac acg gac cac gcc acc tac aag      744
 Asp Ser Arg Glu Ala Phe Glu Ala Tyr Thr Asp His Ala Thr Tyr Lys
             195                 200                 205

 gcc ggc tac ctg tcc acc aac aca cag cag ttc gtg gcg gcc ttc gag      792
 Ala Gly Tyr Leu Ser Thr Asn Thr Gln Gln Phe Val Ala Ala Phe Glu
         210                 215                 220

 gac ggc ccc tac gtc ttc ttt gtc ttc aac cag cag gac aag cac ccg      840
 Asp Gly Pro Tyr Val Phe Phe Val Phe Asn Gln Gln Asp Lys His Pro
     225                 230                 235

 gcc cgg aac cgc acg ctg ctg gca cgc atg tgc aga gaa gac ccc aac      888
 Ala Arg Asn Arg Thr Leu Leu Ala Arg Met Cys Arg Glu Asp Pro Asn
 240                 245                 250                 255

 tac tac tcc tac ctg gag atg gac ctg cag tgc cgg gac ccc gac atc      936
 Tyr Tyr Ser Tyr Leu Glu Met Asp Leu Gln Cys Arg Asp Pro Asp Ile
                 260                 265                 270

 cac gcc gct gcc ttt ggc acc tgc ctg gcc gcc tcc gtg gct gcg cct      984
 His Ala Ala Ala Phe Gly Thr Cys Leu Ala Ala Ser Val Ala Ala Pro
             275                 280                 285

 ggc tct ggc agg gtg cta tat gct gtc ttc agc aga gac agc cgg agc     1032
 Gly Ser Gly Arg Val Leu Tyr Ala Val Phe Ser Arg Asp Ser Arg Ser
         290                 295                 300

 agt ggg ggg ccc ggt gcg ggc ctc tgc ctg ttc ccg ctg gac gag gtg     1080
 Ser Gly Gly Pro Gly Ala Gly Leu Cys Leu Phe Pro Leu Asp Glu Val
     305                 310                 315

 cac gcc aag atg gag gcc aac cgc aac gcc tgt tac aca ggc acc cgg     1128
 His Ala Lys Met Glu Ala Asn Arg Asn Ala Cys Tyr Thr Gly Thr Arg
 320                 325                 330                 335

 gag gcc cgt gac atc ttc tac aag ccc ttc cac ggc gat atc cag tgc     1176
 Glu Ala Arg Asp Ile Phe Tyr Lys Pro Phe His Gly Asp Ile Gln Cys
                 340                 345                 350

 ggc ggc cac gcg ccg ggc tcc agc aag agc ttc cca tgt ggc tcg gag     1224
 Gly Gly His Ala Pro Gly Ser Ser Lys Ser Phe Pro Cys Gly Ser Glu
             355                 360                 365

 cac ctg ccc tac ccg ctg ggc agc cgc gac ggg ctc aga ggc aca gcc     1272
 His Leu Pro Tyr Pro Leu Gly Ser Arg Asp Gly Leu Arg Gly Thr Ala
         370                 375                 380

 gtg ctg cag cgt gga ggc ctg aac ctc acg gcc gtg acg gtc gcc gcc     1320
 Val Leu Gln Arg Gly Gly Leu Asn Leu Thr Ala Val Thr Val Ala Ala
     385                 390                 395

 gag aac aac cac act gtt gct ttt ctg ggc acc tct gat ggc cgg atc     1368
 Glu Asn Asn His Thr Val Ala Phe Leu Gly Thr Ser Asp Gly Arg Ile
 400                 405                 410                 415

 ctc aag gtg tac ctc acc cca gat ggc acc tcc tca gag tac gac tct     1416
 Leu Lys Val Tyr Leu Thr Pro Asp Gly Thr Ser Ser Glu Tyr Asp Ser
                 420                 425                 430

 atc ctt gtg gag ata aac aag aga gtc aag cgc gac ctg gta ctg tct     1464
 Ile Leu Val Glu Ile Asn Lys Arg Val Lys Arg Asp Leu Val Leu Ser
             435                 440                 445

 gga gac ctg ggc agc ctg tac gcc atg acc cag gac aag gtg ttc cgg     1512
 Gly Asp Leu Gly Ser Leu Tyr Ala Met Thr Gln Asp Lys Val Phe Arg
         450                 455                 460

 ctg ccg gtg cag gag tgc ctg agc tac ccg acc tgc acc cag tgc cgc     1560
 Leu Pro Val Gln Glu Cys Leu Ser Tyr Pro Thr Cys Thr Gln Cys Arg
     465                 470                 475

 gac tcc cag gac ccc tac tgc ggc tgg tgc gtc gtc gag gga cga tgc     1608
 Asp Ser Gln Asp Pro Tyr Cys Gly Trp Cys Val Val Glu Gly Arg Cys
 480                 485                 490                 495

 acc cgg aag gcc gag tgt ccg cgg gcc gag gag gcc agc cac tgg ctg     1656
 Thr Arg Lys Ala Glu Cys Pro Arg Ala Glu Glu Ala Ser His Trp Leu
                 500                 505                 510

 tgg agc cga agc aag tcc tgc gtg gcc gtc acc agc gcc cag cca cag     1704
 Trp Ser Arg Ser Lys Ser Cys Val Ala Val Thr Ser Ala Gln Pro Gln
             515                 520                 525

 aac atg agc cgg cgg gcc cag ggg gag gtg cag ctg acc gtc agc ccc     1752
 Asn Met Ser Arg Arg Ala Gln Gly Glu Val Gln Leu Thr Val Ser Pro
         530                 535                 540

 ctc cct gcc ctg agc gag gag gac gag ttg ctg tgc ctt ttt ggg gag     1800
 Leu Pro Ala Leu Ser Glu Glu Asp Glu Leu Leu Cys Leu Phe Gly Glu
     545                 550                 555

 tcg ccg cca cac ccc gcc cgc gtg gag ggc gag gcc gtc atc tgc aac     1848
 Ser Pro Pro His Pro Ala Arg Val Glu Gly Glu Ala Val Ile Cys Asn
 560                 565                 570                 575

 tcc cca agc agc atc ccc gtc aca ccg cca ggc cag gac cac gtg gcc     1896
 Ser Pro Ser Ser Ile Pro Val Thr Pro Pro Gly Gln Asp His Val Ala
                 580                 585                 590

 gtg acc atc cag ctc ctc ctt aga cga ggc aac atc ttc ctc acg tcc     1944
 Val Thr Ile Gln Leu Leu Leu Arg Arg Gly Asn Ile Phe Leu Thr Ser
             595                 600                 605

 tac cag tac ccc ttc tac gac tgc cgc cag gcc atg agc ctg gag gag     1992
 Tyr Gln Tyr Pro Phe Tyr Asp Cys Arg Gln Ala Met Ser Leu Glu Glu
         610                 615                 620

 aac ctg ccg tgc atc tcc tgc gtg agc aac cgc tgg acc tgc cag tgg     2040
 Asn Leu Pro Cys Ile Ser Cys Val Ser Asn Arg Trp Thr Cys Gln Trp
     625                 630                 635

 gac ctg cgc tac cac gag tgc cgg gag gct tcg ccc aac cct gag gac     2088
 Asp Leu Arg Tyr His Glu Cys Arg Glu Ala Ser Pro Asn Pro Glu Asp
 640                 645                 650                 655

 ggc atc gtc cgt gcc cac atg gag gac agc tgt ccc cag ttc ctg gga     2136
 Gly Ile Val Arg Ala His Met Glu Asp Ser Cys Pro Gln Phe Leu Gly
                 660                 665                 670

 ccc agc ccc ctg gtg atc ccc atg aac cac gag aca gat gtg aac ttc     2184
 Pro Ser Pro Leu Val Ile Pro Met Asn His Glu Thr Asp Val Asn Phe
             675                 680                 685

 cag ggc aag aac ctg gac acc gtg aag ggt tcc tcc ctg cac gtg ggc     2232
 Gln Gly Lys Asn Leu Asp Thr Val Lys Gly Ser Ser Leu His Val Gly
         690                 695                 700

 agt gac ttg ctc aag ttc atg gag ccg gtg acc atg cag gaa tct ggg     2280
 Ser Asp Leu Leu Lys Phe Met Glu Pro Val Thr Met Gln Glu Ser Gly
     705                 710                 715

 acc ttc gcc ttt cgg acc cca aag ctg tcc cac gat gcc aac gag acg     2328
 Thr Phe Ala Phe Arg Thr Pro Lys Leu Ser His Asp Ala Asn Glu Thr
 720                 725                 730                 735

 ctg ccc ctg cac ctt tac gtc aag tct tac ggc aag aat atc gac agc     2376
 Leu Pro Leu His Leu Tyr Val Lys Ser Tyr Gly Lys Asn Ile Asp Ser
                 740                 745                 750

 aag ctc cat gtg acc ctc tac gac tgc tcc ttt ggc cgc agc gac tgc     2424
 Lys Leu His Val Thr Leu Tyr Asp Cys Ser Phe Gly Arg Ser Asp Cys
             755                 760                 765

 agc ctg tgc cgg gcc gct aac ccc gac tac agg tgt gcg tgg tgc ggg     2472
 Ser Leu Cys Arg Ala Ala Asn Pro Asp Tyr Arg Cys Ala Trp Cys Gly
         770                 775                 780

 ggc cag agc agg tgc gtg tat gag gcc ctg tgc aac acc acc tcc gag     2520
 Gly Gln Ser Arg Cys Val Tyr Glu Ala Leu Cys Asn Thr Thr Ser Glu
     785                 790                 795

 tgc ccg ccg ccc gtc atc acc agg atc cag cct gag acg ggc ccc ctg     2568
 Cys Pro Pro Pro Val Ile Thr Arg Ile Gln Pro Glu Thr Gly Pro Leu
 800                 805                 810                 815

 ggt ggg ggc atc cgc atc acc atc ctg ggg tcc aat ttg ggc gtc caa     2616
 Gly Gly Gly Ile Arg Ile Thr Ile Leu Gly Ser Asn Leu Gly Val Gln
                 820                 825                 830

 gca ggg gac atc cag agg atc tct gtg gcc ggc cgg aac tgc tcc ttt     2664
 Ala Gly Asp Ile Gln Arg Ile Ser Val Ala Gly Arg Asn Cys Ser Phe
             835                 840                 845

 cag ccg gaa cgt tac tcc gtg tcc acc cgg atc gtg tgt gtg atc gag     2712
 Gln Pro Glu Arg Tyr Ser Val Ser Thr Arg Ile Val Cys Val Ile Glu
         850                 855                 860

 gct gcg gag acg cct ttc acg ggg ggt gtc gag gtg gac gtc ttc ggg     2760
 Ala Ala Glu Thr Pro Phe Thr Gly Gly Val Glu Val Asp Val Phe Gly
     865                 870                 875

 aaa ctg ggc cgt tcg cct ccc aat gtc cag ttc acc ttc caa cag ccc     2808
 Lys Leu Gly Arg Ser Pro Pro Asn Val Gln Phe Thr Phe Gln Gln Pro
 880                 885                 890                 895

 aag cct ctc agt gtg gag ccg cag cag gga ccg cag gcg ggc ggc acc     2856
 Lys Pro Leu Ser Val Glu Pro Gln Gln Gly Pro Gln Ala Gly Gly Thr
                 900                 905                 910

 aca ctg acc atc cac ggc acc cac ctg gac acg ggc tcc cag gag gac     2904
 Thr Leu Thr Ile His Gly Thr His Leu Asp Thr Gly Ser Gln Glu Asp
             915                 920                 925

 gtg cgg gtg acc ctc aac ggc gtc ccg tgt aaa gtg acg aag ttt ggg     2952
 Val Arg Val Thr Leu Asn Gly Val Pro Cys Lys Val Thr Lys Phe Gly
         930                 935                 940

 gcg cag ctc cag tgt gtc act ggc ccc cag gcg aca cgg ggc cag atg     3000
 Ala Gln Leu Gln Cys Val Thr Gly Pro Gln Ala Thr Arg Gly Gln Met
     945                 950                 955

 ctt ctg gag gtc tcc tac ggg ggg tcc ccc gtg ccc aac ccc ggc atc     3048
 Leu Leu Glu Val Ser Tyr Gly Gly Ser Pro Val Pro Asn Pro Gly Ile
 960                 965                 970                 975

 ttc ttc acc tac cgc gaa aac ccc gta ctg cga gcc ttc gag ccg cta     3096
 Phe Phe Thr Tyr Arg Glu Asn Pro Val Leu Arg Ala Phe Glu Pro Leu
                 980                 985                 990

 cga agc ttt gcc agt ggt ggc cgc agc atc aac gtc acg ggt cag ggc     3144
 Arg Ser Phe Ala Ser Gly Gly Arg Ser Ile Asn Val Thr Gly Gln Gly
             995                1000                1005

 ttc agc ctg atc cag agg ttt gcc atg gtg gtc atc gcg gag ccc ctg     3192
 Phe Ser Leu Ile Gln Arg Phe Ala Met Val Val Ile Ala Glu Pro Leu
        1010                1015                1020

 cag tcc tgg cag ccg ccg cgg gag gct gaa tcc ctg cag ccc atg acg     3240
 Gln Ser Trp Gln Pro Pro Arg Glu Ala Glu Ser Leu Gln Pro Met Thr
    1025                1030                1035

 gtg gtg ggt aca gac tac gtg ttc cac aat gac acc aag gtc gtc ttc     3288
 Val Val Gly Thr Asp Tyr Val Phe His Asn Asp Thr Lys Val Val Phe
1040                1045                1050                1055

 ctg tcc ccg gct gtg cct gag gag cca gag gcc tac aac ctc acg gtg     3336
 Leu Ser Pro Ala Val Pro Glu Glu Pro Glu Ala Tyr Asn Leu Thr Val
                1060                1065                1070

 ctg atc gag atg gac ggg cac cgt gcc ctg ctc aga aca gag gcc ggg     3384
 Leu Ile Glu Met Asp Gly His Arg Ala Leu Leu Arg Thr Glu Ala Gly
            1075                1080                1085

 gcc ttc gag tac gtg cct gac ccc acc ttt gag aac ttc aca ggt ggc     3432
 Ala Phe Glu Tyr Val Pro Asp Pro Thr Phe Glu Asn Phe Thr Gly Gly
        1090                1095                1100

 gtc aag aag cag gtc aac aag ctc atc cac gcc cgg ggc acc aat ctg     3480
 Val Lys Lys Gln Val Asn Lys Leu Ile His Ala Arg Gly Thr Asn Leu
    1105                1110                1115

 aac aag gcg atg acg ctg cag gag gcc gag gcc ttc gtg ggt gcc gag     3528
 Asn Lys Ala Met Thr Leu Gln Glu Ala Glu Ala Phe Val Gly Ala Glu
1120                1125                1130                1135

 cgc tgc acc atg aag acg ctg acg gag acc gac ctg tac tgt gag ccc     3576
 Arg Cys Thr Met Lys Thr Leu Thr Glu Thr Asp Leu Tyr Cys Glu Pro
                1140                1145                1150

 ccg gag gtg cag ccc ccg ccc aag cgg cgg cag aaa cga gac acc aca     3624
 Pro Glu Val Gln Pro Pro Pro Lys Arg Arg Gln Lys Arg Asp Thr Thr
            1155                1160                1165

 cac aac ctg ccc gag ttc att gtg aag ttc ggc tct cgc gag tgg gtg     3672
 His Asn Leu Pro Glu Phe Ile Val Lys Phe Gly Ser Arg Glu Trp Val
        1170                1175                1180

 ctg ggc cgc gtg gag tac gac aca cgg gtg agc gac gtg ccg ctc agc     3720
 Leu Gly Arg Val Glu Tyr Asp Thr Arg Val Ser Asp Val Pro Leu Ser
    1185                1190                1195

 ctc atc ttg ccg ctg gtc atc gtg ccc atg gtg gtc gtc atc gcg gtg     3768
 Leu Ile Leu Pro Leu Val Ile Val Pro Met Val Val Val Ile Ala Val
1200                1205                1210                1215

 tct gtc tac tgc tac tgg agg aag agc cag cag gcc gaa cga gag tat     3816
 Ser Val Tyr Cys Tyr Trp Arg Lys Ser Gln Gln Ala Glu Arg Glu Tyr
                1220                1225                1230

 gag aag atc aag tcc cag ctg gag ggc ctg gag gag agc gtg cgg gac     3864
 Glu Lys Ile Lys Ser Gln Leu Glu Gly Leu Glu Glu Ser Val Arg Asp
            1235                1240                1245

 cgc tgc aag aag gaa ttc aca gac ctg atg atc gag atg gag gac cag     3912
 Arg Cys Lys Lys Glu Phe Thr Asp Leu Met Ile Glu Met Glu Asp Gln
        1250                1255                1260

 acc aac gac gtg cac gag gcc ggc atc ccc gtg ctg gac tac aag acc     3960
 Thr Asn Asp Val His Glu Ala Gly Ile Pro Val Leu Asp Tyr Lys Thr
    1265                1270                1275

 tac acc gac cgc gtc ttc ttc ctg ccc tcc aag gac ggc gac aag gac     4008
 Tyr Thr Asp Arg Val Phe Phe Leu Pro Ser Lys Asp Gly Asp Lys Asp
1280                1285                1290                1295

 gtg atg atc acc ggc aag ctg gac atc ccc gag ccg cgg cgg ccg gtg     4056
 Val Met Ile Thr Gly Lys Leu Asp Ile Pro Glu Pro Arg Arg Pro Val
                1300                1305                1310

 gtg gag cag gcc ctc tac cag ttc tcc aac ctg ctg aac agc aag tct     4104
 Val Glu Gln Ala Leu Tyr Gln Phe Ser Asn Leu Leu Asn Ser Lys Ser
            1315                1320                1325

 ttc ctc atc aat ttc atc cac acc ctg gag aac cag cgg gag ttc tcg     4152
 Phe Leu Ile Asn Phe Ile His Thr Leu Glu Asn Gln Arg Glu Phe Ser
        1330                1335                1340

 gcc cgc gcc aag gtc tac ttc gcg tcc ctg ctg acg gtg gcg ctg cac     4200
 Ala Arg Ala Lys Val Tyr Phe Ala Ser Leu Leu Thr Val Ala Leu His
    1345                1350                1355

 ggg aaa ctg gag tac tac acg gac atc atg cac acg ctc ttc ctg gag     4248
 Gly Lys Leu Glu Tyr Tyr Thr Asp Ile Met His Thr Leu Phe Leu Glu
1360                1365                1370                1375

 ctc ctg gag cag tac gtg gtg gcc aag aac ccc aag ctg atg ctg cgc     4296
 Leu Leu Glu Gln Tyr Val Val Ala Lys Asn Pro Lys Leu Met Leu Arg
                1380                1385                1390

 agg tct gag act gtg gtg gag agg atg ctg tcc aac tgg atg tcc atc     4344
 Arg Ser Glu Thr Val Val Glu Arg Met Leu Ser Asn Trp Met Ser Ile
            1395                1400                1405

 tgc ctg tac cag tac ctc aag gac agt gcc ggg gag ccc ctg tac aag     4392
 Cys Leu Tyr Gln Tyr Leu Lys Asp Ser Ala Gly Glu Pro Leu Tyr Lys
        1410                1415                1420

 ctc ttc aag gcc atc aaa cat cag gtg gaa aag ggc ccg gtg gat gcg     4440
 Leu Phe Lys Ala Ile Lys His Gln Val Glu Lys Gly Pro Val Asp Ala
    1425                1430                1435

 gta cag aag aag gcc aag tac act ctc aac gac acg ggg ctg ctg ggg     4488
 Val Gln Lys Lys Ala Lys Tyr Thr Leu Asn Asp Thr Gly Leu Leu Gly
1440                1445                1450                1455

 gat gat gtg gag tac gca ccc ctg acg gtg agc gtg atc gtg cag gac     4536
 Asp Asp Val Glu Tyr Ala Pro Leu Thr Val Ser Val Ile Val Gln Asp
                1460                1465                1470

 gag gga gtg gac gcc atc ccg gtg aag gtc ctc aac tgt gac acc atc     4584
 Glu Gly Val Asp Ala Ile Pro Val Lys Val Leu Asn Cys Asp Thr Ile
            1475                1480                1485

 tcc cag gtc aag gag aag atc att gac cag gtg tac cgt ggg cag ccc     4632
 Ser Gln Val Lys Glu Lys Ile Ile Asp Gln Val Tyr Arg Gly Gln Pro
        1490                1495                1500

 tgc tcc tgc tgg ccc agg cca gac agc gtg gtc ctg gag tgg cgt ccg     4680
 Cys Ser Cys Trp Pro Arg Pro Asp Ser Val Val Leu Glu Trp Arg Pro
    1505                1510                1515

 ggc tcc aca gcg cag atc ctg tcg gac ctg gac ctg acg tca cag cgg     4728
 Gly Ser Thr Ala Gln Ile Leu Ser Asp Leu Asp Leu Thr Ser Gln Arg
1520                1525                1530                1535

 gag ggc cgg tgg aag cgc gtc aac acc ctt atg cac tac aat gtc cgg     4776
 Glu Gly Arg Trp Lys Arg Val Asn Thr Leu Met His Tyr Asn Val Arg
                1540                1545                1550

 gat gga gcc acc ctc atc ctg tcc aag gtg ggg gtc tcc cag cag ccg     4824
 Asp Gly Ala Thr Leu Ile Leu Ser Lys Val Gly Val Ser Gln Gln Pro
            1555                1560                1565

 gag gac agc cag cag gac ctg cct ggg gag cgc cat gcc ctc ctg gag     4872
 Glu Asp Ser Gln Gln Asp Leu Pro Gly Glu Arg His Ala Leu Leu Glu
        1570                1575                1580

 gag gag aac cgg gtg tgg cac ctg gtg cgg ccg acc gac gag gtg gac     4920
 Glu Glu Asn Arg Val Trp His Leu Val Arg Pro Thr Asp Glu Val Asp
    1585                1590                1595

 gag ggc aag tcc aag aga ggc agc gtg aaa gag aag gag cgg acg aag     4968
 Glu Gly Lys Ser Lys Arg Gly Ser Val Lys Glu Lys Glu Arg Thr Lys
1600                1605                1610                1615

 gcc atc acc gag atc tac ctg acg cgg ctg ctc tca gtc aag ggc aca     5016
 Ala Ile Thr Glu Ile Tyr Leu Thr Arg Leu Leu Ser Val Lys Gly Thr
                1620                1625                1630

 ctg cag cag ttt gtg gac aac ttc ttc cag agc gtg ctg gcg cct ggg     5064
 Leu Gln Gln Phe Val Asp Asn Phe Phe Gln Ser Val Leu Ala Pro Gly
            1635                1640                1645

 cac gcg gtg cca cct gca gtc aag tac ttc ttc gac ttc ctg gac gag     5112
 His Ala Val Pro Pro Ala Val Lys Tyr Phe Phe Asp Phe Leu Asp Glu
        1650                1655                1660

 cag gca gag aag cac aac atc cag gat gaa gac acc atc cac atc tgg     5160
 Gln Ala Glu Lys His Asn Ile Gln Asp Glu Asp Thr Ile His Ile Trp
    1665                1670                1675

 aag acg aac agt tta ccg ctc cgg ttc tgg gtg aac atc ctc aag aac     5208
 Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys Asn
1680                1685                1690                1695

 ccc cac ttc atc ttt gac gtg cat gtc cac gag gtg gtg gac gcc tcg     5256
 Pro His Phe Ile Phe Asp Val His Val His Glu Val Val Asp Ala Ser
                1700                1705                1710

 ctg tca gtc atc gcg cag acc ttc atg gat gcc tgc acg cgc acg gag     5304
 Leu Ser Val Ile Ala Gln Thr Phe Met Asp Ala Cys Thr Arg Thr Glu
            1715                1720                1725

 cat aag ctg agc cgc gat tct ccc agc aac aag ctg ctg tac gcc aag     5352
 His Lys Leu Ser Arg Asp Ser Pro Ser Asn Lys Leu Leu Tyr Ala Lys
        1730                1735                1740

 gag atc tcc acc tac aag aag atg gtg gag gat tac tac aag ggg atc     5400
 Glu Ile Ser Thr Tyr Lys Lys Met Val Glu Asp Tyr Tyr Lys Gly Ile
    1745                1750                1755

 cgg cag atg gtg cag gtc agc gac cag gac atg aac aca cac ctg gca     5448
 Arg Gln Met Val Gln Val Ser Asp Gln Asp Met Asn Thr His Leu Ala
1760                1765                1770                1775

 gag att tcc cgg gcg cac acg gac tcc ttg aac acc ctc gtg gca ctc     5496
 Glu Ile Ser Arg Ala His Thr Asp Ser Leu Asn Thr Leu Val Ala Leu
                1780                1785                1790

 cac cag ctc tac caa tac acg cag aag tac tat gac gag atc atc aat     5544
 His Gln Leu Tyr Gln Tyr Thr Gln Lys Tyr Tyr Asp Glu Ile Ile Asn
            1795                1800                1805

 gcc ttg gag gag gat cct gcc gcc cag aag atg cag ctg gcc ttc cgc     5592
 Ala Leu Glu Glu Asp Pro Ala Ala Gln Lys Met Gln Leu Ala Phe Arg
        1810                1815                1820

 ctg cag cag att gcc gct gca ctg gag aac aag gtc act gac ctc tga     5640
 Leu Gln Gln Ile Ala Ala Ala Leu Glu Asn Lys Val Thr Asp Leu 
    1825                1830                1835

 cctacaatct ccagtgctgc cttgggacat aggtacctga ggtacctgag agcccctcag   5700

 gggaggaggc cgagtggctg tggctgaggc ccccaccctc ccctggaacg cgccccaagc   5760

 cggagtgggt gcagccggaa cccgcccagc gtctagactg tagcatcttc ctctgagcaa   5820

 taccgccggg caccgcacca gcaccagccc cagccccagc tccctccggc cgcagaacca   5880

 gcatcgggtg ttcactgtcg agtctcgagt gatttgaaaa tgtgccttac gctgccacgc   5940

 tgggggcagc tggcctccgc ctccgcccac gcaccagcag ccgcctccat gccctaggtt   6000

 gggcccctgg gggatctgag ggcctgtggc ccccagggca agttcccaga tcctatgtct   6060

 gtctgtccac cacgagatgg gaggaggaga aaaagcggta cgatgccttc ctgacctcac   6120

 cggcctcccc aagggtgccg gcactctggg tggactcacg gctgctgggc cccacgtcaa   6180

 aggtcaagtg agacgtaggt caagtcctac gtcggggccc agacatcctg gggtcctggt   6240

 ctgtcagaca ggctgcccta gagccccacc cagtccgggg ggactgggag cagttccaag   6300

 accaccccac ccctttttgt aaatcttgtt cattgtaaat caaatacagc gtctttttca   6360

 ctctgaaaaa aaaaaaa                                                  6377




      <210> 365
      <211> 2088
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (151)..(1914)

      <400> 365
 ggcacgaggc ggagcgccgg gacgccaagc acttcctgcc gcgggcggcg cgccgcagct     60

 gcccaggccg gaccgggccg ggcgcccgca gatgagcccc gctagggccg ccccgcgctg    120

 agagcccagc cccgccgctg cccgcccgcc     atg tct cag atg ctg cac atc     171
                                      Met Ser Gln Met Leu His Ile
                                        1               5

 gag atc ccc aac ttc ggg aac aca gtg ctg ggc tgc ctg aac gag cag      219
 Glu Ile Pro Asn Phe Gly Asn Thr Val Leu Gly Cys Leu Asn Glu Gln
          10                  15                  20

 cgc ctg ctg ggc ctc tac tgc gat gtg tcc atc gtg gtc aag ggc cag      267
 Arg Leu Leu Gly Leu Tyr Cys Asp Val Ser Ile Val Val Lys Gly Gln
      25                  30                  35

 gcc ttc aag gcc cac cgg gcg gtg ctg gcc gcc agc agc ctc tac ttc      315
 Ala Phe Lys Ala His Arg Ala Val Leu Ala Ala Ser Ser Leu Tyr Phe
  40                  45                  50                  55

 cgc gac ctg ttc agc ggc aac agc aag agc gcc ttc gag ctg ccc ggc      363
 Arg Asp Leu Phe Ser Gly Asn Ser Lys Ser Ala Phe Glu Leu Pro Gly
                  60                  65                  70

 tcc gtg ccg ccc gcc tgc ttc cag cag atc ctg tcc ttc tgc tac acg      411
 Ser Val Pro Pro Ala Cys Phe Gln Gln Ile Leu Ser Phe Cys Tyr Thr
              75                  80                  85

 ggc agg ctc acc atg acg gcc agc gag cag ctc gtg gtc atg tac acg      459
 Gly Arg Leu Thr Met Thr Ala Ser Glu Gln Leu Val Val Met Tyr Thr
          90                  95                 100

 gcc ggc ttc ctg cag atc cag cac atc gtg gag cgc ggc acc gac ctc      507
 Ala Gly Phe Leu Gln Ile Gln His Ile Val Glu Arg Gly Thr Asp Leu
     105                 110                 115

 atg ttc aag gtg agc tcg ccc cac tgc gac tcg cag acc gct gtg atc      555
 Met Phe Lys Val Ser Ser Pro His Cys Asp Ser Gln Thr Ala Val Ile
 120                 125                 130                 135

 gag gac gcc ggc tcc gag ccc cag agc ccc tgc aac cag ctg cag ccg      603
 Glu Asp Ala Gly Ser Glu Pro Gln Ser Pro Cys Asn Gln Leu Gln Pro
                 140                 145                 150

 gcc gcc gcc gcc gcg gcc ccc tac gtc gtg tcc ccc tcg gtg ccc atc      651
 Ala Ala Ala Ala Ala Ala Pro Tyr Val Val Ser Pro Ser Val Pro Ile
             155                 160                 165

 ccg ctg ctg acc cga gta aag cat gaa gcc atg gag ctg ccg ccg gcc      699
 Pro Leu Leu Thr Arg Val Lys His Glu Ala Met Glu Leu Pro Pro Ala
         170                 175                 180

 ggc cca ggc ctg gcc ccc aag cgc ccg ctg gag acg ggg ccc cgg gac      747
 Gly Pro Gly Leu Ala Pro Lys Arg Pro Leu Glu Thr Gly Pro Arg Asp
     185                 190                 195

 ggc gtg gcg gtg gcc gcg ggg gct gcg gtg gcg gcg ggc aca gcc cct      795
 Gly Val Ala Val Ala Ala Gly Ala Ala Val Ala Ala Gly Thr Ala Pro
 200                 205                 210                 215

 ctc aaa ctg ccc cgt gtc tcc tac tac ggg gtg ccc agc ctg gcc acc      843
 Leu Lys Leu Pro Arg Val Ser Tyr Tyr Gly Val Pro Ser Leu Ala Thr
                 220                 225                 230

 ctc atc ccc ggc atc cag cag atg ccc tac ccc cag ggg gag cgg acc      891
 Leu Ile Pro Gly Ile Gln Gln Met Pro Tyr Pro Gln Gly Glu Arg Thr
             235                 240                 245

 agt cca ggc gcc agc agc ctg ccc acc acc gac agc ccc acc tcg tac      939
 Ser Pro Gly Ala Ser Ser Leu Pro Thr Thr Asp Ser Pro Thr Ser Tyr
         250                 255                 260

 cac aac gag gag gac gag gag gac gac gag gcc tac gac acc atg gtg      987
 His Asn Glu Glu Asp Glu Glu Asp Asp Glu Ala Tyr Asp Thr Met Val
     265                 270                 275

 gag gag cag tac ggc cag atg tac atc aag gcc tcc ggc agc tat gca     1035
 Glu Glu Gln Tyr Gly Gln Met Tyr Ile Lys Ala Ser Gly Ser Tyr Ala
 280                 285                 290                 295

 gtg caa gag aag cct gag cca gtg ccg ctg gag agc cgc tcc tgc gtc     1083
 Val Gln Glu Lys Pro Glu Pro Val Pro Leu Glu Ser Arg Ser Cys Val
                 300                 305                 310

 ctc atc cgc cgc gac ctc gtg gcc cta cct gcc agc ctc atc agc cag     1131
 Leu Ile Arg Arg Asp Leu Val Ala Leu Pro Ala Ser Leu Ile Ser Gln
             315                 320                 325

 atc gga tac cgc tgc cat ccc aag ctc tac tcg gaa ggg gac ccc ggg     1179
 Ile Gly Tyr Arg Cys His Pro Lys Leu Tyr Ser Glu Gly Asp Pro Gly
         330                 335                 340

 gag aag ctg gag ctg gtg gca ggc tct ggg gtc tac atc aca cgc ggc     1227
 Glu Lys Leu Glu Leu Val Ala Gly Ser Gly Val Tyr Ile Thr Arg Gly
     345                 350                 355

 cag ctg atg aac tgc cac ctg tgt gca ggg gtg aag cat aag gtc ttg     1275
 Gln Leu Met Asn Cys His Leu Cys Ala Gly Val Lys His Lys Val Leu
 360                 365                 370                 375

 ctg cgg agg ctc ctg gcc acc ttc ttt gac agg aac acg ctg gcc aac     1323
 Leu Arg Arg Leu Leu Ala Thr Phe Phe Asp Arg Asn Thr Leu Ala Asn
                 380                 385                 390

 agc tgc ggg act ggc atc cgc tcg tcc acc agc gac ccc agc cgg aag     1371
 Ser Cys Gly Thr Gly Ile Arg Ser Ser Thr Ser Asp Pro Ser Arg Lys
             395                 400                 405

 ccg ctg gac agc cgg gtc ctg aac gct gtg aaa ttg tac tgt cag aac     1419
 Pro Leu Asp Ser Arg Val Leu Asn Ala Val Lys Leu Tyr Cys Gln Asn
         410                 415                 420

 ttc gcc ccc agc ttc aag gag agc gag atg aac gtg atc gcc gcg gac     1467
 Phe Ala Pro Ser Phe Lys Glu Ser Glu Met Asn Val Ile Ala Ala Asp
     425                 430                 435

 atg tgc acc aac gcc cgc cgc gtt cgc aag cgc tgg ctg ccc aag atc     1515
 Met Cys Thr Asn Ala Arg Arg Val Arg Lys Arg Trp Leu Pro Lys Ile
 440                 445                 450                 455

 aag tcc atg ctg ccg gag ggc gtg gag atg tac cgc acg gtc atg ggc     1563
 Lys Ser Met Leu Pro Glu Gly Val Glu Met Tyr Arg Thr Val Met Gly
                 460                 465                 470

 tcc gcc gcc gcc agc gtg ccc ctc gac ccc gag ttc ccg ccc gcc gcg     1611
 Ser Ala Ala Ala Ser Val Pro Leu Asp Pro Glu Phe Pro Pro Ala Ala
             475                 480                 485

 gca cag gtg ttc gag caa cgc atc tac gcc gag cgg cgg ggc gac gcc     1659
 Ala Gln Val Phe Glu Gln Arg Ile Tyr Ala Glu Arg Arg Gly Asp Ala
         490                 495                 500

 gcc acc atc gtg gct ctg aga act gac gcc gtg aat gtt gac ctg agt     1707
 Ala Thr Ile Val Ala Leu Arg Thr Asp Ala Val Asn Val Asp Leu Ser
     505                 510                 515

 gcc gcc gcc aac ccc gcc ttc gac gcc ggc gag gag gtg gac ggg gct     1755
 Ala Ala Ala Asn Pro Ala Phe Asp Ala Gly Glu Glu Val Asp Gly Ala
 520                 525                 530                 535

 ggc tcg gtc atc cag gag gtg gcc gcc ccc gag ccg ctg ccc gcc gat     1803
 Gly Ser Val Ile Gln Glu Val Ala Ala Pro Glu Pro Leu Pro Ala Asp
                 540                 545                 550

 ggc cag agc ccc cca cag ccc ttt gag cag ggc ggg ggc ggc ccc agc     1851
 Gly Gln Ser Pro Pro Gln Pro Phe Glu Gln Gly Gly Gly Gly Pro Ser
             555                 560                 565

 agg ccc cag acg ccg gcg gcc gcg gcc cgg agg ccg gag ggc acc tat     1899
 Arg Pro Gln Thr Pro Ala Ala Ala Ala Arg Arg Pro Glu Gly Thr Tyr
         570                 575                 580

 gca ggg acc ttg taa gcggagctgg gtggctgcgc gagggaccga gtactagagc     1954
 Ala Gly Thr Leu 
     585

 tgcttgcatg cgttactaat acaaacaaat gtgatcaagc cacttaccta ctgaactgct   2014

 actgttgcct gagaaaaatg tgatttttat tctgcttgta tttaaaattg atgaaggaaa   2074

 aaaaaaaaaa aaaa                                                     2088




      <210> 366
      <211> 3221
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (270)..(2075)

      <400> 366
 accggcccgg aattcccggg tcgacgagct cactagtcgg cgtacgcctg caggtaccgg     60

 tccggaattc ccgggtcgac ttcgctgcga cgatttcgta atgaagcagt ttccagggcc    120

 tccaggatag attgttctcc tctgaaagtg acaacagcct gtacttcacc tacagtggcc    180

 agcccaacac cctggaggtc agagacctca actgccaggt ggacctggcc tctcaggtcc    240

 cttggtttga gcagctggct cagttcaag  atg ccc tgg aca tct ccc agc tgc     293
                                  Met Pro Trp Thr Ser Pro Ser Cys
                                    1               5

 cag aat tct tgt gag ctg ggc atc cag aac cta agc ttc aaa gtg aga      341
 Gln Asn Ser Cys Glu Leu Gly Ile Gln Asn Leu Ser Phe Lys Val Arg
      10                  15                  20

 agt ggg cag atg ctg gcc atc ata ggg agc tca ggt tgt ggg aga gcc      389
 Ser Gly Gln Met Leu Ala Ile Ile Gly Ser Ser Gly Cys Gly Arg Ala
  25                  30                  35                  40

 tcc ttg cta gat gtg atc act ggc cga ggt cac ggc ggc aag atc aag      437
 Ser Leu Leu Asp Val Ile Thr Gly Arg Gly His Gly Gly Lys Ile Lys
                  45                  50                  55

 tca ggc cag atc tgg atc aat ggg cag ccc agc tcg cct cag ctg gtg      485
 Ser Gly Gln Ile Trp Ile Asn Gly Gln Pro Ser Ser Pro Gln Leu Val
              60                  65                  70

 agg aag tgt gtg gcc cac gtg cgc cag cac aac cag ctg ctc ccc aac      533
 Arg Lys Cys Val Ala His Val Arg Gln His Asn Gln Leu Leu Pro Asn
          75                  80                  85

 ttg act gtg cga gag acc ttg gcc ttc att gcc cag atg cgg ctg ccc      581
 Leu Thr Val Arg Glu Thr Leu Ala Phe Ile Ala Gln Met Arg Leu Pro
      90                  95                 100

 aga acc ttc tcc cag gcc cag cgt gac aaa agg gtg gag gac gtg atc      629
 Arg Thr Phe Ser Gln Ala Gln Arg Asp Lys Arg Val Glu Asp Val Ile
 105                 110                 115                 120

 gcg gag ctg cgg ctt agg cag tgc gct gac acc cgc gtg ggc aac atg      677
 Ala Glu Leu Arg Leu Arg Gln Cys Ala Asp Thr Arg Val Gly Asn Met
                 125                 130                 135

 tac gtg cgg ggg ttg tcg ggg ggt gag cgc agg aga gtc agc att ggg      725
 Tyr Val Arg Gly Leu Ser Gly Gly Glu Arg Arg Arg Val Ser Ile Gly
             140                 145                 150

 gtg cag ctc ctg tgg aac cca gga atc ctt att ctc gac gaa ccc acc      773
 Val Gln Leu Leu Trp Asn Pro Gly Ile Leu Ile Leu Asp Glu Pro Thr
         155                 160                 165

 tct ggg ctc gac agc ttc aca gcc cac aac ctg gtg aag acc ttg tcc      821
 Ser Gly Leu Asp Ser Phe Thr Ala His Asn Leu Val Lys Thr Leu Ser
     170                 175                 180

 agg ctg gcc aaa ggc aac cgg ctg gtg ctc atc tcc ctc cac cag cct      869
 Arg Leu Ala Lys Gly Asn Arg Leu Val Leu Ile Ser Leu His Gln Pro
 185                 190                 195                 200

 cgc tct gac atc ttc agg ctg ttt gat ctg gtc ctc ctg atg acg tct      917
 Arg Ser Asp Ile Phe Arg Leu Phe Asp Leu Val Leu Leu Met Thr Ser
                 205                 210                 215

 ggc acc ccc atc tac tta ggg gcg gcc cag cac atg gtc cag tat ttc      965
 Gly Thr Pro Ile Tyr Leu Gly Ala Ala Gln His Met Val Gln Tyr Phe
             220                 225                 230

 aca gcc atc ggc tac ccc tgt cct cgc tac agc aat cct gct gac ttc     1013
 Thr Ala Ile Gly Tyr Pro Cys Pro Arg Tyr Ser Asn Pro Ala Asp Phe
         235                 240                 245

 tat gtg gac ctg acc agc att gac agg cgc agc aga gag cag gaa ttg     1061
 Tyr Val Asp Leu Thr Ser Ile Asp Arg Arg Ser Arg Glu Gln Glu Leu
     250                 255                 260

 gcc acc agg gag aag gct cag tca ctc gca gcc ctg ttt cta gaa aaa     1109
 Ala Thr Arg Glu Lys Ala Gln Ser Leu Ala Ala Leu Phe Leu Glu Lys
 265                 270                 275                 280

 gtg cgt gac tta gat gac ttt cta tgg aaa gca gag acg aag gat ctt     1157
 Val Arg Asp Leu Asp Asp Phe Leu Trp Lys Ala Glu Thr Lys Asp Leu
                 285                 290                 295

 gac gag gac acc tgt gtg gaa agc agc gtg acc cca cta gac acc aac     1205
 Asp Glu Asp Thr Cys Val Glu Ser Ser Val Thr Pro Leu Asp Thr Asn
             300                 305                 310

 tgc ctc ccg agt cct acg aag atg cct ggg gcg gtg cag cag ttt aag     1253
 Cys Leu Pro Ser Pro Thr Lys Met Pro Gly Ala Val Gln Gln Phe Lys
         315                 320                 325

 acg ctg atc cgt cgt cag att tcc aac gac ttc cga gac ctg ccc acc     1301
 Thr Leu Ile Arg Arg Gln Ile Ser Asn Asp Phe Arg Asp Leu Pro Thr
     330                 335                 340

 ctc ctc atc cat ggg gcg gag gcc tgt ctg atg tca atg acc atc ggc     1349
 Leu Leu Ile His Gly Ala Glu Ala Cys Leu Met Ser Met Thr Ile Gly
 345                 350                 355                 360

 ttc ctc tat ttt ggc cat ggg agc atc cag ctc tcc ttc atg gat aca     1397
 Phe Leu Tyr Phe Gly His Gly Ser Ile Gln Leu Ser Phe Met Asp Thr
                 365                 370                 375

 gcc gcc ctc ttg ttc atg atc ggt gct ctc atc cct ttc aac gtc att     1445
 Ala Ala Leu Leu Phe Met Ile Gly Ala Leu Ile Pro Phe Asn Val Ile
             380                 385                 390

 ctg gat gtc atc tcc aaa tgt tac tca gag agg gca atg ctt tac tat     1493
 Leu Asp Val Ile Ser Lys Cys Tyr Ser Glu Arg Ala Met Leu Tyr Tyr
         395                 400                 405

 gaa ctg gaa gac ggg ctg tac acc act ggt cca tat ttc ttt gcc aag     1541
 Glu Leu Glu Asp Gly Leu Tyr Thr Thr Gly Pro Tyr Phe Phe Ala Lys
     410                 415                 420

 atc ctc ggg gag ctt ccg gag cac tgt gcc tac atc atc atc tac ggg     1589
 Ile Leu Gly Glu Leu Pro Glu His Cys Ala Tyr Ile Ile Ile Tyr Gly
 425                 430                 435                 440

 atg ccc acc tac tgg ctg gcc aac ctg agg cca ggc ctc cag ccc ttc     1637
 Met Pro Thr Tyr Trp Leu Ala Asn Leu Arg Pro Gly Leu Gln Pro Phe
                 445                 450                 455

 ctg ctg cac ttc ctg ctg gtg tgg ctg gtg gtc ttc tgt tgc agg att     1685
 Leu Leu His Phe Leu Leu Val Trp Leu Val Val Phe Cys Cys Arg Ile
             460                 465                 470

 atg gcc ctg gcc gcc gcg gcc ctg ctc ccc acc ttc cac atg gcc tcc     1733
 Met Ala Leu Ala Ala Ala Ala Leu Leu Pro Thr Phe His Met Ala Ser
         475                 480                 485

 ttc ttc agc aat gcc ctc tac aac tcc ttc tac ctc gcc ggg ggc ttc     1781
 Phe Phe Ser Asn Ala Leu Tyr Asn Ser Phe Tyr Leu Ala Gly Gly Phe
     490                 495                 500

 atg ata aac ttg agc agc ctg tgg aca gtg ccc gcg tgg att tcc aaa     1829
 Met Ile Asn Leu Ser Ser Leu Trp Thr Val Pro Ala Trp Ile Ser Lys
 505                 510                 515                 520

 gtg tcc ttc ctg cgg tgg tgt ttt gaa ggg ctg atg aag att cag ttc     1877
 Val Ser Phe Leu Arg Trp Cys Phe Glu Gly Leu Met Lys Ile Gln Phe
                 525                 530                 535

 agc aga aga act tat aaa atg cct ctc ggg aac ctc acc atc gcg gtc     1925
 Ser Arg Arg Thr Tyr Lys Met Pro Leu Gly Asn Leu Thr Ile Ala Val
             540                 545                 550

 tca gga gat aaa atc ctc agt gcc atg gag ctg gac tcg tac cct ctc     1973
 Ser Gly Asp Lys Ile Leu Ser Ala Met Glu Leu Asp Ser Tyr Pro Leu
         555                 560                 565

 tac gcc atc tac ctc atc gtc att ggc ctc agc ggt ggc ttc atg gtc     2021
 Tyr Ala Ile Tyr Leu Ile Val Ile Gly Leu Ser Gly Gly Phe Met Val
     570                 575                 580

 ctg tac tac gtg tcc tta agg ttc atc aaa cag aaa cca agt caa gac     2069
 Leu Tyr Tyr Val Ser Leu Arg Phe Ile Lys Gln Lys Pro Ser Gln Asp
 585                 590                 595                 600

 tgg tga ttcacgccag acgtctgccc gctggtgggg gacctgagca gacccttcaa      2125
 Trp 


 ctgcactccc tcctcaggag ccccttcctg gggacagtga ggacaatgac cctacagatg   2185

 ctcagctaca tccggcccag ggtgctgcag tggcacagac cagccacagg atggcagtag   2245

 aataaagaca gtcgaaaggg atttctgctc actggcagga gactgcgatg actgggagaa   2305

 aacctgcact cggtggcacc tacaacgttg ctaatttatt tccttttgat atgcatttat   2365

 ataggcaact cgatatagga tgggagcaaa ctaggaatga attgggtagc tagactgtgc   2425

 aggaattgtt ggaacctgga gggaacaata acagtagcta gcagatttgg cttcatcttc   2485

 caggggcccc acactccgtg gtgagccacc atcaatacag aaagtgacct aagatgtacc   2545

 agcaagatgc catcccttct ttttgtgtgg ggtcatgggc tccaaaagcc aacgtgaaca   2605

 attaaaaatg tattgagcat ctactctgta gcaggtcctg tgaaaacact ttaggtggac   2665

 aatcccttga ggtaagtggt atcccatttt ataggtgtga aaactgaagc aaaaattcat   2725

 tttcctaagg gcacatggat actttgtggt ggagtcatat ggggatcaga aaagcctttg   2785

 aggcctttgg agttagaggg cagaaggcaa ggcctgagcc tctgtaagcc ttaggagttt   2845

 aggaaggctc cagaagacaa atggggtctg tagaggctgt taactcagcc aggcttctta   2905

 gagttgcatt tcactaactg atatggtttg gctctgcgtc ctcacccaaa tctcaccttg   2965

 aattgtaata atccccaagt ttcaagggct ggaccagatg gagataattt attcataggg   3025

 gttgtttctc tgatgctgtt ctcctgtaga gtgagttgat tcttatgaga tccgacggtt   3085

 ttataaggtg ttttcctctt cgtttggttg ctcagtcttt tttcccgtta tcttgtttaa   3145

 gtggtgcctt tcatctcgac tggcaatttt cttaaggctg ttccatcctg tcttaatttt   3205

 tgttaatttt actgga                                                   3221




      <210> 367
      <211> 1710
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (192)..(1337)

      <400> 367
 agcggccgcc gcgcgccagc gggaggcgct ccctctgccc acctccgccc cctgcggacc     60

 gagacccgga gatgtcgagt tgtggagttc ggctcggccc ggcgacgggc tagctgcccg    120

 ggaacccccg cgggtggaca catgcatgcc ggagctccgg gaggggccgc gccgccaccg    180

 tctgaactag g atg tcc cga cat gaa ggt gtc agc tgt gat gca tgt tta     230
              Met Ser Arg His Glu Gly Val Ser Cys Asp Ala Cys Leu
                1               5                  10

 aaa gga aat ttt cga ggt cgc aga tat aag tgt tta att tgc tac gat      278
 Lys Gly Asn Phe Arg Gly Arg Arg Tyr Lys Cys Leu Ile Cys Tyr Asp
      15                  20                  25

 tac gat ctt tgt gca tct tgt tat gaa agt ggt gca aca aca aca agg      326
 Tyr Asp Leu Cys Ala Ser Cys Tyr Glu Ser Gly Ala Thr Thr Thr Arg
  30                  35                  40                  45

 cat aca act gac cac cca atg cag tgc ata tta aca agg gta gat ttt      374
 His Thr Thr Asp His Pro Met Gln Cys Ile Leu Thr Arg Val Asp Phe
                  50                  55                  60

 gat tta tac tat ggt ggg gaa gct ttc tct gta gag cag cca cag tct      422
 Asp Leu Tyr Tyr Gly Gly Glu Ala Phe Ser Val Glu Gln Pro Gln Ser
              65                  70                  75

 ttt act tgt ccc tat tgt gga aaa atg ggc tat acg gag aca tct ctt      470
 Phe Thr Cys Pro Tyr Cys Gly Lys Met Gly Tyr Thr Glu Thr Ser Leu
          80                  85                  90

 caa gaa cat gtt act tct gaa cat gca gaa aca tca aca gaa gtg att      518
 Gln Glu His Val Thr Ser Glu His Ala Glu Thr Ser Thr Glu Val Ile
      95                 100                 105

 tgt cca ata tgt gca gcg tta cct gga ggc gat cct aat cat gtc acg      566
 Cys Pro Ile Cys Ala Ala Leu Pro Gly Gly Asp Pro Asn His Val Thr
 110                 115                 120                 125

 gat gac ttt gca gct cat ctt aca ctt gaa cac aga gcc cct aga gat      614
 Asp Asp Phe Ala Ala His Leu Thr Leu Glu His Arg Ala Pro Arg Asp
                 130                 135                 140

 tta gat gaa tcg agt ggt gtt cga cat gta cgt aga atg ttt cac cct      662
 Leu Asp Glu Ser Ser Gly Val Arg His Val Arg Arg Met Phe His Pro
             145                 150                 155

 ggc cgg gga tta gga ggt cct cgt gct cgt aga tca aac atg cac ttt      710
 Gly Arg Gly Leu Gly Gly Pro Arg Ala Arg Arg Ser Asn Met His Phe
         160                 165                 170

 act agc agt tct act ggt gga ctt tct tct tct cag agt tca tat tct      758
 Thr Ser Ser Ser Thr Gly Gly Leu Ser Ser Ser Gln Ser Ser Tyr Ser
     175                 180                 185

 cca agc aat agg gaa gcc atg gat cct ata gct gag ctt tta tct cag      806
 Pro Ser Asn Arg Glu Ala Met Asp Pro Ile Ala Glu Leu Leu Ser Gln
 190                 195                 200                 205

 tta tca gga gtg aga cgt tct gca gga gga cag ctt aat tcc tct ggc      854
 Leu Ser Gly Val Arg Arg Ser Ala Gly Gly Gln Leu Asn Ser Ser Gly
                 210                 215                 220

 cct tcc gct tct cag tta caa caa ctg cag atg cag ctg cag cta gaa      902
 Pro Ser Ala Ser Gln Leu Gln Gln Leu Gln Met Gln Leu Gln Leu Glu
             225                 230                 235

 cgg cag cat gcc cag gca gca cgg caa caa ctg gag acc gca cgc aac      950
 Arg Gln His Ala Gln Ala Ala Arg Gln Gln Leu Glu Thr Ala Arg Asn
         240                 245                 250

 gca acc cgg cgt act aac aca agc agt gtc acc act aca atc aca caa      998
 Ala Thr Arg Arg Thr Asn Thr Ser Ser Val Thr Thr Thr Ile Thr Gln
     255                 260                 265

 tcc aca gca aca acc aac ata gct aat aca gaa agc agt cag cag act     1046
 Ser Thr Ala Thr Thr Asn Ile Ala Asn Thr Glu Ser Ser Gln Gln Thr
 270                 275                 280                 285

 cta cag aat tcc cag ttt ctt tta aca agg ttg aat gat cct aaa atg     1094
 Leu Gln Asn Ser Gln Phe Leu Leu Thr Arg Leu Asn Asp Pro Lys Met
                 290                 295                 300

 tct gaa acg gag cgc cag tcc atg gaa agc gag cgt gca gac cgc agc     1142
 Ser Glu Thr Glu Arg Gln Ser Met Glu Ser Glu Arg Ala Asp Arg Ser
             305                 310                 315

 ctg ttt gtc caa gag ctc ctt ctg tcc act tta gtg cgt gaa gag agc     1190
 Leu Phe Val Gln Glu Leu Leu Leu Ser Thr Leu Val Arg Glu Glu Ser
         320                 325                 330

 tca tcc tca gat gag gat gat cgg ggg gag atg gca gat ttt ggt gct     1238
 Ser Ser Ser Asp Glu Asp Asp Arg Gly Glu Met Ala Asp Phe Gly Ala
     335                 340                 345

 atg ggc tgt gta gat att atg cct tta gat gtt gct tta gaa aac cta     1286
 Met Gly Cys Val Asp Ile Met Pro Leu Asp Val Ala Leu Glu Asn Leu
 350                 355                 360                 365

 aat tta aaa gag agt aat aaa gga aat gag cct cca cca cct cct ctt     1334
 Asn Leu Lys Glu Ser Asn Lys Gly Asn Glu Pro Pro Pro Pro Pro Leu
                 370                 375                 380

 tga tgac atcccaattc gcagacaatg tcctctgtgc tgtatttgcc aatgaaagtg     1391
 


 gacaacaact atcttgggtt tgtttggtga ttgtaatttc aggtctgtca ctcttgttac   1451

 attgtgtaca ttcaaaagga agagagaaaa tatatatgat aatcatttcc acttaactaa   1511

 tttttacttc tagcaggtaa atgtaggtag cagtgcaggg gtgatctctg cttcctgtac   1571

 cttgacatgc aaaaggctct cctaatactc cacattcaaa ctgaagagga aaattgaaat   1631

 ctctaatgaa gctgctgtgt gtatttatga atattaatga ataaaaactg cttggatggt   1691

 ttaccttaaa aaaaaaaaa                                                1710




      <210> 368
      <211> 650
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (23)..(640)

      <400> 368
 tgtggtggaa ttcatctgca cc atg ccc tgg gcc ctg ctc ctc ctg acc ctc      52
                          Met Pro Trp Ala Leu Leu Leu Leu Thr Leu
                            1               5                  10

 ctc act cac tct gca gtg tca gtg gtc cag gca ggc ctg act cag cca      100
 Leu Thr His Ser Ala Val Ser Val Val Gln Ala Gly Leu Thr Gln Pro
                  15                  20                  25

 ccc tcg atg tcc aag gac ttg gga cag acc gcc acg ctc atc tgc agt      148
 Pro Ser Met Ser Lys Asp Leu Gly Gln Thr Ala Thr Leu Ile Cys Ser
              30                  35                  40

 ggg aac ggc aac aat gtt ggc aat cag gga gca gct tgg ctc cag ctg      196
 Gly Asn Gly Asn Asn Val Gly Asn Gln Gly Ala Ala Trp Leu Gln Leu
          45                  50                  55

 cag cag ggc cac cct ccc aaa ctc ctt tcg cac agg aat aat aac cga      244
 Gln Gln Gly His Pro Pro Lys Leu Leu Ser His Arg Asn Asn Asn Arg
      60                  65                  70

 ccc tca ggg atc tca gag aga ttc tct gca acc aag tca gac agt aca      292
 Pro Ser Gly Ile Ser Glu Arg Phe Ser Ala Thr Lys Ser Asp Ser Thr
  75                  80                  85                  90

 gcc tcc ctg acc atc act gac ctc cag cct gag gac gag ggc gtc tat      340
 Ala Ser Leu Thr Ile Thr Asp Leu Gln Pro Glu Asp Glu Gly Val Tyr
                  95                 100                 105

 tac tgt tcg gca tgg gac agt act ctc cgt gcc cag gtg ttc ggc gga      388
 Tyr Cys Ser Ala Trp Asp Ser Thr Leu Arg Ala Gln Val Phe Gly Gly
             110                 115                 120

 ggc acc aag ttg acc gtc ctg cgt cag ccc aag gct gcc ccc tcg gtc      436
 Gly Thr Lys Leu Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val
         125                 130                 135

 act ctg ttc cca ccc tcc tct gag gag ctt caa gcc aac aag gcc aca      484
 Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr
     140                 145                 150

 ctg gtg tgt ctc ata agt gac ttc tac ccg gga gcc gtg aca gtg gcc      532
 Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala
 155                 160                 165                 170

 tgg aag gca caa agc agc ccc gtc aag gcg gga gtg aaa acc acc aca      580
 Trp Lys Ala Gln Ser Ser Pro Val Lys Ala Gly Val Lys Thr Thr Thr
                 175                 180                 185

 ccc ttc caa caa agc aac aac aag tac gcg cgc agc agc tac ctg agc      628
 Pro Phe Gln Gln Ser Asn Asn Lys Tyr Ala Arg Ser Ser Tyr Leu Ser
             190                 195                 200

 ctg acg cct tga gcagtggaat                                           650
 Leu Thr Pro 
         205





      <210> 369
      <211> 1701
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (210)..(1283)

      <400> 369
 agagagacgc ctctaggggc agaggccctg ggaggcaaag acccccagga gagatttacc     60

 caccccagac ggaaagcgcg gctcagagtc ggacgagggg agactgtcag aggacaacgc    120

 cccctaggtc tcctgggaga ccccgaagcg accccggggg cagcccgggc cgtgtccggg    180

 cgagggtgac ctatccttgg ttgagagcg  atg ggg aca caa gcc ctg cag ggc     233
                                  Met Gly Thr Gln Ala Leu Gln Gly
                                    1               5

 ttc ctc ttt ctc ctc ttc ctc ccg ctg ctg cag ccg cgt ggg gcc tcg      281
 Phe Leu Phe Leu Leu Phe Leu Pro Leu Leu Gln Pro Arg Gly Ala Ser
      10                  15                  20

 gct ggg agc ctg cac agt cca ggc ctg tcc gaa tgc ttc cag gtg aat      329
 Ala Gly Ser Leu His Ser Pro Gly Leu Ser Glu Cys Phe Gln Val Asn
  25                  30                  35                  40

 ggg gct gac tac cgc ggc cac cag aac cgc act ggc ccg cgc ggg gcg      377
 Gly Ala Asp Tyr Arg Gly His Gln Asn Arg Thr Gly Pro Arg Gly Ala
                  45                  50                  55

 ggc cgc ccg tgc ctc ttc tgg gac cag acg cag caa cac agc tac agc      425
 Gly Arg Pro Cys Leu Phe Trp Asp Gln Thr Gln Gln His Ser Tyr Ser
              60                  65                  70

 agc gcc agc ggc ccc agc ggc acc tcc acg aag ctc acg gtc cag gtg      473
 Ser Ala Ser Gly Pro Ser Gly Thr Ser Thr Lys Leu Thr Val Gln Val
          75                  80                  85

 tgc cta cgc ttc tgc cgc atg aag ggg tac cag ctg gcg ggc gtg gag      521
 Cys Leu Arg Phe Cys Arg Met Lys Gly Tyr Gln Leu Ala Gly Val Glu
      90                  95                 100

 gcc ggt tac gcc tgc ttc tgt ggc tct gaa agc gac ctg gcc cgg gga      569
 Ala Gly Tyr Ala Cys Phe Cys Gly Ser Glu Ser Asp Leu Ala Arg Gly
 105                 110                 115                 120

 cgc ctg gcc ccc gcc acc gac tgt gac cag atc tgt ttc ggc cac cct      617
 Arg Leu Ala Pro Ala Thr Asp Cys Asp Gln Ile Cys Phe Gly His Pro
                 125                 130                 135

 gga cag ctg tgt ggc ggc gat ggg cgg ctg ggc gtc tat gaa gtg tcg      665
 Gly Gln Leu Cys Gly Gly Asp Gly Arg Leu Gly Val Tyr Glu Val Ser
             140                 145                 150

 gtg ggc tcc tgc cag ggg aac tgg aca gcg cct cag ggc gtc atc tac      713
 Val Gly Ser Cys Gln Gly Asn Trp Thr Ala Pro Gln Gly Val Ile Tyr
         155                 160                 165

 tcc ccg gac ttc ccg gac gag tac ggg ccg gac cgg aac tgc agc tgg      761
 Ser Pro Asp Phe Pro Asp Glu Tyr Gly Pro Asp Arg Asn Cys Ser Trp
     170                 175                 180

 gcc ctg ggc ccg cca ggc gcc gcg ctg gag ctc acc ttc cgc ctc ttc      809
 Ala Leu Gly Pro Pro Gly Ala Ala Leu Glu Leu Thr Phe Arg Leu Phe
 185                 190                 195                 200

 gag ctg gcc gac ccg cgc gac cgg ctg gag ctg cgc gac gcg gct tcg      857
 Glu Leu Ala Asp Pro Arg Asp Arg Leu Glu Leu Arg Asp Ala Ala Ser
                 205                 210                 215

 ggc agc ctg ctc cgc gcc ttc gat ggc gcc cgc cca ccg ccg tcc ggg      905
 Gly Ser Leu Leu Arg Ala Phe Asp Gly Ala Arg Pro Pro Pro Ser Gly
             220                 225                 230

 ccg ctg cgc ctg ggc act gcc gcg ctg ctg ctc acc ttc cga agc gac      953
 Pro Leu Arg Leu Gly Thr Ala Ala Leu Leu Leu Thr Phe Arg Ser Asp
         235                 240                 245

 gcg cgc ggc cac gcg caa ggc ttc gcg ctc acc tac cgc ggg ctg cag     1001
 Ala Arg Gly His Ala Gln Gly Phe Ala Leu Thr Tyr Arg Gly Leu Gln
     250                 255                 260

 gac gcc gct gag gac cca gag gcc ccc gag ggc tcg gcc cag acc ccc     1049
 Asp Ala Ala Glu Asp Pro Glu Ala Pro Glu Gly Ser Ala Gln Thr Pro
 265                 270                 275                 280

 gcg gcg ccc ctc gac ggg gcc aac gtg agc tgc agc ccc agg cct ggg     1097
 Ala Ala Pro Leu Asp Gly Ala Asn Val Ser Cys Ser Pro Arg Pro Gly
                 285                 290                 295

 gct ccg ccg gcc gcg att ggg gga gct gtc tgc tgg ctc cgg gaa aag     1145
 Ala Pro Pro Ala Ala Ile Gly Gly Ala Val Cys Trp Leu Arg Glu Lys
             300                 305                 310

 ggc ccc cgg cgc tgg ggg ctt cca ggg gcc cca gga gaa gct ggg ctg     1193
 Gly Pro Arg Arg Trp Gly Leu Pro Gly Ala Pro Gly Glu Ala Gly Leu
         315                 320                 325

 tgt ggt acc aac agc ccc gag ggg tgg cct tgc cct gct ccc ccg ggg     1241
 Cys Gly Thr Asn Ser Pro Glu Gly Trp Pro Cys Pro Ala Pro Pro Gly
     330                 335                 340

 acc ccc agg ctg agg gtt ctg ccg cgg gct acc ggc ctc tga gtgcctc     1290
 Thr Pro Arg Leu Arg Val Leu Pro Arg Ala Thr Gly Leu 
 345                 350                 355

 cagccagagc tccctgcgct cgctcatctc cgctctctga ctctgggccc cgagggtccg   1350

 ctgggcccgc cgccggcgag atggacacct gagatgctgt gctgcgccct gcctcggcct   1410

 tgcgcctgtg taggggcagc tcggcctctg gtcgccttgg ggagaccaaa agtcggacag   1470

 gaaacatctg gtgctattat ctgggacttg gcctgaccgt gggggtccag atggtccagg   1530

 ccctctccat ggacctgtat gtgggggtgg tctctggttt cggaggtctt tgaacccctc   1590

 tgggggtggt cctggactgc cgtcctcagt gagaggtcac aggtcagcaa aaacagtcaa   1650

 aaaaccccca cagattttga ataaaggatc tactttggaa aaaaaaaaaa a            1701




      <210> 370
      <211> 1348
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (210)..(815)

      <400> 370
 ctcactatag ggctcggcgc cgccggcagg tcagcaagtt cttaaaactg tttcacctga     60

 ccacatagtg ccccatggcc ccagcttcct ccgtactctc accagctctg agaaccaaac    120

 ccagaagagg ccagagaagg aaacgagaga tgtgagaagg aaaaagagcc tcagaccctg    180

 ctgccacaag ggacttccat gctggtgag  atg acc cag agg gct ggg gct gcc     233
                                  Met Thr Gln Arg Ala Gly Ala Ala
                                    1               5

 atg ctg cct tca gct ctg ctc ctt ctc tgt gtc cca ggc tgt ctg act      281
 Met Leu Pro Ser Ala Leu Leu Leu Leu Cys Val Pro Gly Cys Leu Thr
      10                  15                  20

 gtg agt ggc ccc agc acc gtg atg ggc gcc gtg ggg gaa tcc ctg agt      329
 Val Ser Gly Pro Ser Thr Val Met Gly Ala Val Gly Glu Ser Leu Ser
  25                  30                  35                  40

 gtt cag tgt cgg tat gaa gag aaa tac aag acg ttt aac aaa tac tgg      377
 Val Gln Cys Arg Tyr Glu Glu Lys Tyr Lys Thr Phe Asn Lys Tyr Trp
                  45                  50                  55

 tgc aga caa cca tgc ttg cca att tgg cat gaa atg gtg gag acc gga      425
 Cys Arg Gln Pro Cys Leu Pro Ile Trp His Glu Met Val Glu Thr Gly
              60                  65                  70

 ggg tct gag gga gtg gtg agg agt gac caa gtg atc atc acg gac cat      473
 Gly Ser Glu Gly Val Val Arg Ser Asp Gln Val Ile Ile Thr Asp His
          75                  80                  85

 cct gga gac ctc acc ttc acc gtg acc ttg gag aac ctc acg gca gac      521
 Pro Gly Asp Leu Thr Phe Thr Val Thr Leu Glu Asn Leu Thr Ala Asp
      90                  95                 100

 gat gca gga aaa tac cga tgt ggg att gca aca ata ctg cag gaa gat      569
 Asp Ala Gly Lys Tyr Arg Cys Gly Ile Ala Thr Ile Leu Gln Glu Asp
 105                 110                 115                 120

 ggc ctg tct ggt ttc ctg ccc gat ccc ttc ttc cag gtt caa gtg ctg      617
 Gly Leu Ser Gly Phe Leu Pro Asp Pro Phe Phe Gln Val Gln Val Leu
                 125                 130                 135

 gtc tca tcg gcc tcc agt act gag aac tct gtg aag aca cct gca tct      665
 Val Ser Ser Ala Ser Ser Thr Glu Asn Ser Val Lys Thr Pro Ala Ser
             140                 145                 150

 ccc acc agg ccc agc caa tgc caa ggg tcc ctg ccc agc agc acc tgc      713
 Pro Thr Arg Pro Ser Gln Cys Gln Gly Ser Leu Pro Ser Ser Thr Cys
         155                 160                 165

 ttc ctg ctt ctc cca ctc ctg aag gtg cct ctg ctc ctg agc ata ctc      761
 Phe Leu Leu Leu Pro Leu Leu Lys Val Pro Leu Leu Leu Ser Ile Leu
     170                 175                 180

 ggt gct atc ctc tgg gtg aac agg cct tgg agg act cct tgg aca gag      809
 Gly Ala Ile Leu Trp Val Asn Arg Pro Trp Arg Thr Pro Trp Thr Glu
 185                 190                 195                 200

 tca tga acaggagaac ttgcaacacc ccatgcccat tggaaccctg tccagagaca       865
 Ser 


 cagcccctct gactgcaaaa aggacttctg accctgaccc tcatatttct ttccatctta    925

 tcaccggata ctttttaaaa gttaaaaaaa aatgtaggcc gggtgcggtg gcttacacct    985

 gcaatcccag cactttggga ggccaaggca ggtggatcac ttgagtccag gagtttgaga   1045

 gcagcctggg cagcatggtc agacctcatc tctacaaaaa aatacaaaaa ttagcagggt   1105

 gtggtggtgt atgcctgtga tcccagctac ttgggaagct gagacaggag gatcgcttga   1165

 gccccggagt ggaggttgca ttgagtcgag attgtgccac tgcactccag cctgggtgac   1225

 agagggagac cctgtctcag ataaacaaat aaataaataa aatacatccc atacacaaga   1285

 gtatgtatat gaggtatcta tacagttcaa ggactaaaaa taaacatgtg tacccaccat   1345

 tcg                                                                 1348




      <210> 371
      <211> 1433
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1116)

      <400> 371
  atg gcc gtc atg gcg ccc cga acc ctc ctc ctg cta ctc tcg ggg gcc      48
  Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala
    1               5                  10                  15

 ctg gcc ctg acc cag acc tgg gcg ggc tcc cac tcc atg agg tat ttc       96
 Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe
              20                  25                  30

 tac acc tcc gtg tcc cgg ccc ggc cgc ggg gag ccc cgc ttc atc gcc      144
 Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala
          35                  40                  45

 gtg ggc tac gtg gac gac acg cag ttc gtg cgg ttc gac agc gac gcc      192
 Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala
      50                  55                  60

 gcg agc cag agg atg gag ccg cgg gcg ccg tgg ata gag cag gag ggg      240
 Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly
  65                  70                  75                  80

 ccg gag tat tgg gac cag gag aca cgg aat gtg aag gcc cag tca cag      288
 Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln
                  85                  90                  95

 act gac cga gtg gac ctg ggg acc ctg cgc ggc tac tac aac cag agc      336
 Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser
             100                 105                 110

 gag gac ggt tct cac acc atc cag ata atg tat ggc tgc gac gtg ggg      384
 Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly
         115                 120                 125

 ccg gac ggg cgc ttc ctc cgc ggg tac cgg cag gac gcc tac gac ggc      432
 Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly
     130                 135                 140

 aag gat tac atc gcc ctg aac gag gac ctg cgc tct tgg acc gcg gcg      480
 Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala
 145                 150                 155                 160

 gac atg gca gct cag atc acc aag cgc aag tgg gag gcg gcc cgt gag      528
 Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala Arg Glu
                 165                 170                 175

 gcg gag cag cag aga gcc tac ctg gag ggc cgg tgc gtg gag tgg ctc      576
 Ala Glu Gln Gln Arg Ala Tyr Leu Glu Gly Arg Cys Val Glu Trp Leu
             180                 185                 190

 cgc aga tac ctg gag aac ggg aag gag acg ctg cag cgc acg gac ccc      624
 Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro
         195                 200                 205

 ccc aag aca cat atg acc cac cac ccc atc tct gac cat gag gcc acc      672
 Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr
     210                 215                 220

 ctg agg tgc tgg gcc ctg ggc ttc tac cct gcg gag atc aca ctg acc      720
 Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr
 225                 230                 235                 240

 tgg cag cgg gat ggg gag gac cag acc cag gac acg gag ctc gtg gag      768
 Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu
                 245                 250                 255

 acc agg cct gca ggg gat gga acc ttc cag aag tgg gcg gct gtg gtg      816
 Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val
             260                 265                 270

 gtg cct tct gga gag gag cag aga tac acc tgc cat gtg cag cat gag      864
 Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu
         275                 280                 285

 ggt ctg ccc aag ccc ctc acc ctg aga tgg gag ctg tct tcc cag ccc      912
 Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro
     290                 295                 300

 acc atc ccc atc gtg ggc atc att gct ggc ctg gtt ctc ctt gga gct      960
 Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala
 305                 310                 315                 320

 gtg atc act gga gct gtg gtc gct gcc gtg atg tgg agg agg aag agc     1008
 Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser
                 325                 330                 335

 tca ggt gga gaa ggg gtg aaa gat aga aaa gga ggg agt tac act cag     1056
 Ser Gly Gly Glu Gly Val Lys Asp Arg Lys Gly Gly Ser Tyr Thr Gln
             340                 345                 350

 gct gca agc agt gac agt gcc cag ggc tct gat gtg tct ctc aca gct     1104
 Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu Thr Ala
         355                 360                 365

 tgt aaa gtg tga gac agctgccttg tgtgggactg agaggcaaga gttgttcctg     1159
 Cys Lys Val 
     370

 cccttccctt tgtgacttga agaaccctga ctttgtttct gcaaaggcac ctgcatgtgt   1219

 ctgtgttcgt gtaggcataa tgtgaggagg tggggagacc accccacccc gatgtccacc   1279

 atgaccctct tcccacgctg acctgtgctc cctctccaat catctttcct gttccagaga   1339

 ggtggggctg aggtgtctcc atctctgtct caacttcatg gtgcactgag ctgtaacttc   1399

 ttccttccct attaaaatta gaacctgagt ataa                               1433




      <210> 372
      <211> 823
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2)..(454)

      <220>
      <221> misc_feature
      <222> (1)...(823)
      <223> n = a,t,c or g

      <400> 372
 c    aag ctt gct gat gcc ggg gag gcc ctc acg ttc cct gag ggt tat      46
      Lys Leu Ala Asp Ala Gly Glu Ala Leu Thr Phe Pro Glu Gly Tyr
        1               5                  10                  15

 gcc aaa ggc tcg tcg cag ctg ctg ctc cca gcc acc ttc ctc tct gca       94
 Ala Lys Gly Ser Ser Gln Leu Leu Leu Pro Ala Thr Phe Leu Ser Ala
                  20                  25                  30

 gag ctt gcc ctt ctg cag aag tcc ttt cat gtg aat atc cag gat aca      142
 Glu Leu Ala Leu Leu Gln Lys Ser Phe His Val Asn Ile Gln Asp Thr
              35                  40                  45

 atg att ggt gag ctg ccc cca caa acc acc aag acc ctg gct cgc ttc      190
 Met Ile Gly Glu Leu Pro Pro Gln Thr Thr Lys Thr Leu Ala Arg Phe
          50                  55                  60

 att cct gaa gtg gct gta gct tat ccc aag tca aag ccc ttg acg acc      238
 Ile Pro Glu Val Ala Val Ala Tyr Pro Lys Ser Lys Pro Leu Thr Thr
      65                  70                  75

 cag atc aag ata aag aag cct ccc aag gtc act atg aag aca ggc aag      286
 Gln Ile Lys Ile Lys Lys Pro Pro Lys Val Thr Met Lys Thr Gly Lys
  80                  85                  90                  95

 agc ctg ctg cac ctc cac agc acc ctg gag atg ttc gca gct cgg tgg      334
 Ser Leu Leu His Leu His Ser Thr Leu Glu Met Phe Ala Ala Arg Trp
                 100                 105                 110

 cgg agc aag gct cca atg tcc ctc ttt ctc cta gaa gtg cac ttc aat      382
 Arg Ser Lys Ala Pro Met Ser Leu Phe Leu Leu Glu Val His Phe Asn
             115                 120                 125

 ctg aag gtc cag tac tca gtg cat gag aac cag ctg cag atg gcc act      430
 Leu Lys Val Gln Tyr Ser Val His Glu Asn Gln Leu Gln Met Ala Thr
         130                 135                 140

 tct ttg gac agg aga ggg aat taa ctggcttcat caccagctat ctcgaagaag     484
 Ser Leu Asp Arg Arg Gly Asn 
     145                 150

 cctacatccc agttgtcaat gatgtgcttc aagtggggct cccactcccg gactttctgg    544

 ccatgaatta caacctggct gagctggaca tagtagagaa tgccctgatg ctggacttga    604

 agctgggctg accatggcag gactcccctg ccagctgcct gcttaccacc aaccacctgc    664

 accccatgga ggagaccccc tgattggagc caggtgggcc tggcccccta ccactggtgg    724

 ctgcctcctt tgacaaggag tgaatgggtc angcctgggc tggagccttg ccaataaaca    784

 ggagaaaggc tcttataaat atctgaaaaa aaaaaaaaa                           823




      <210> 373
      <211> 1365
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1365)

      <400> 373
  atg ctg cgg atc ctg tgc ctg gca ctc tgc agc ctg ctg act ggc acg      48
  Met Leu Arg Ile Leu Cys Leu Ala Leu Cys Ser Leu Leu Thr Gly Thr
    1               5                  10                  15

 cga gct gac cct ggg gca ctg ctg cgg ttg ggc atg gac atc atg aac       96
 Arg Ala Asp Pro Gly Ala Leu Leu Arg Leu Gly Met Asp Ile Met Asn
              20                  25                  30

 cgt gag gtc cag agc gcc atg gat gag agt cat atc ctg gag aag atg      144
 Arg Glu Val Gln Ser Ala Met Asp Glu Ser His Ile Leu Glu Lys Met
          35                  40                  45

 gca gcc gag gca ggc aag aaa cag cca ggg atg aaa cct atc aag ggc      192
 Ala Ala Glu Ala Gly Lys Lys Gln Pro Gly Met Lys Pro Ile Lys Gly
      50                  55                  60

 atc acc aat ttg aag gtg aag gat gtc cag ctg ccc gtc atc aca ctg      240
 Ile Thr Asn Leu Lys Val Lys Asp Val Gln Leu Pro Val Ile Thr Leu
  65                  70                  75                  80

 aac ttt gta cct gga gtg ggc atc ttc caa tgt gtg tcc aca ggc atg      288
 Asn Phe Val Pro Gly Val Gly Ile Phe Gln Cys Val Ser Thr Gly Met
                  85                  90                  95

 acc gtc act ggc aag agc ttc atg gga ggg aac atg gag atc atc gtg      336
 Thr Val Thr Gly Lys Ser Phe Met Gly Gly Asn Met Glu Ile Ile Val
             100                 105                 110

 gcc ctg aac atc aca gcc acc aac cgg ctt ctg cgg gat gag gag aca      384
 Ala Leu Asn Ile Thr Ala Thr Asn Arg Leu Leu Arg Asp Glu Glu Thr
         115                 120                 125

 ggc ctc ccc gtg ttc aag agt gag ggc tgt gag gtc atc ctg gtc aat      432
 Gly Leu Pro Val Phe Lys Ser Glu Gly Cys Glu Val Ile Leu Val Asn
     130                 135                 140

 gtg aag act aac ctg cct agc aac atg ctc ccc aag atg gtc aac aag      480
 Val Lys Thr Asn Leu Pro Ser Asn Met Leu Pro Lys Met Val Asn Lys
 145                 150                 155                 160

 ttc ctg gac agc acc ctg cac aaa gtc ctc cct ggg ctg atg tgt ccc      528
 Phe Leu Asp Ser Thr Leu His Lys Val Leu Pro Gly Leu Met Cys Pro
                 165                 170                 175

 gcc atc gat gca gtc ctg gtg tat gtg aac agg aag tgg acc aac ctc      576
 Ala Ile Asp Ala Val Leu Val Tyr Val Asn Arg Lys Trp Thr Asn Leu
             180                 185                 190

 agt gac ccc atg cct gtg ggc cag atg ggc acc gtc aaa tat gtt ctg      624
 Ser Asp Pro Met Pro Val Gly Gln Met Gly Thr Val Lys Tyr Val Leu
         195                 200                 205

 atg tcc gca cca gcc acc aca gcc agc tac atc caa ctg gac ttc agt      672
 Met Ser Ala Pro Ala Thr Thr Ala Ser Tyr Ile Gln Leu Asp Phe Ser
     210                 215                 220

 cct gtg gtg cag cag caa aag ggc aaa acc atc aag ctt gct gat gcc      720
 Pro Val Val Gln Gln Gln Lys Gly Lys Thr Ile Lys Leu Ala Asp Ala
 225                 230                 235                 240

 ggg gag gcc ctc acg ttc cct gag ggt tat gcc aaa ggc tcg tcg cag      768
 Gly Glu Ala Leu Thr Phe Pro Glu Gly Tyr Ala Lys Gly Ser Ser Gln
                 245                 250                 255

 ctg ctg ctc cca gcc acc ttc ctc tct gca gag ctt gcc ctt ctg cag      816
 Leu Leu Leu Pro Ala Thr Phe Leu Ser Ala Glu Leu Ala Leu Leu Gln
             260                 265                 270

 aag tcc ttt cat gtg aat atc cag gat aca atg att ggt gag ctg ccc      864
 Lys Ser Phe His Val Asn Ile Gln Asp Thr Met Ile Gly Glu Leu Pro
         275                 280                 285

 cca caa acc acc aag acc ctg gct cgc ttc att cct gaa gtg gct gta      912
 Pro Gln Thr Thr Lys Thr Leu Ala Arg Phe Ile Pro Glu Val Ala Val
     290                 295                 300

 gct tat ccc aag tca aag ccc ttg acg acc cag atc aag ata aag aag      960
 Ala Tyr Pro Lys Ser Lys Pro Leu Thr Thr Gln Ile Lys Ile Lys Lys
 305                 310                 315                 320

 cct ccc aag gtc act atg aag aca ggc aag agc ctg ctg cac ctc cac     1008
 Pro Pro Lys Val Thr Met Lys Thr Gly Lys Ser Leu Leu His Leu His
                 325                 330                 335

 agc acc ctg gag atg ttc gca gct cgg tgg cgg agc aag gct cca atg     1056
 Ser Thr Leu Glu Met Phe Ala Ala Arg Trp Arg Ser Lys Ala Pro Met
             340                 345                 350

 tcc ctc ttt ctc cta gaa gtg cac ttc aat ctg aag gtc cag tac tca     1104
 Ser Leu Phe Leu Leu Glu Val His Phe Asn Leu Lys Val Gln Tyr Ser
         355                 360                 365

 gtg cat gag aac cag ctg cag atg gcc act tct ttg gac aga tta ctg     1152
 Val His Glu Asn Gln Leu Gln Met Ala Thr Ser Leu Asp Arg Leu Leu
     370                 375                 380

 agc ttg tcc cgg aag tcc tca tcg att ggc aac ttc aat gag agg gaa     1200
 Ser Leu Ser Arg Lys Ser Ser Ser Ile Gly Asn Phe Asn Glu Arg Glu
 385                 390                 395                 400

 tta act ggc ttc atc acc agc tat ctc gaa gaa gcc tac atc cca gtt     1248
 Leu Thr Gly Phe Ile Thr Ser Tyr Leu Glu Glu Ala Tyr Ile Pro Val
                 405                 410                 415

 gtc aat gat gtg ctt caa gtg ggg ctc cca ctc ccg gac ttt ctg gcc     1296
 Val Asn Asp Val Leu Gln Val Gly Leu Pro Leu Pro Asp Phe Leu Ala
             420                 425                 430

 atg aat tac aac ctg gct gag ctg gac ata gta gag ctt ggg ggc atc     1344
 Met Asn Tyr Asn Leu Ala Glu Leu Asp Ile Val Glu Leu Gly Gly Ile
         435                 440                 445

 atg gaa cct gcc gac ata tga                                         1365
 Met Glu Pro Ala Asp Ile 
     450





      <210> 374
      <211> 1526
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1158)

      <400> 374
  atg ctg cgg atc ctg tgc ctg gca ctc tgc agc ctg ctg act ggc acg      48
  Met Leu Arg Ile Leu Cys Leu Ala Leu Cys Ser Leu Leu Thr Gly Thr
    1               5                  10                  15

 cga gct gac cct ggg gca ctg ctg cgg ttg ggc atg gac atc atg aac       96
 Arg Ala Asp Pro Gly Ala Leu Leu Arg Leu Gly Met Asp Ile Met Asn
              20                  25                  30

 cgt gag gtc cag agc gcc atg gat gag agt cat atc ctg gag aag atg      144
 Arg Glu Val Gln Ser Ala Met Asp Glu Ser His Ile Leu Glu Lys Met
          35                  40                  45

 gca gcc gag gca ggc aag aaa cag cca ggg atg aaa cct atc aag ggc      192
 Ala Ala Glu Ala Gly Lys Lys Gln Pro Gly Met Lys Pro Ile Lys Gly
      50                  55                  60

 atc acc aat ttg aag gtg aag gat gtc cag ctg ccc gtc atc aca ctg      240
 Ile Thr Asn Leu Lys Val Lys Asp Val Gln Leu Pro Val Ile Thr Leu
  65                  70                  75                  80

 aac ttt gta cct gga gtg ggc atc ttc caa tgt gtg tcc aca ggc atg      288
 Asn Phe Val Pro Gly Val Gly Ile Phe Gln Cys Val Ser Thr Gly Met
                  85                  90                  95

 acc gtc act ggc aag agc ttc atg gga ggg aac atg gag atc atc gtg      336
 Thr Val Thr Gly Lys Ser Phe Met Gly Gly Asn Met Glu Ile Ile Val
             100                 105                 110

 gcc ctg aac atc aca gcc acc aac cgg ctt ctg cgg gat gag gag aca      384
 Ala Leu Asn Ile Thr Ala Thr Asn Arg Leu Leu Arg Asp Glu Glu Thr
         115                 120                 125

 ggc ctc ccc gtg ttc aag agt gag ggc tgt gag gtc atc ctg gtc aat      432
 Gly Leu Pro Val Phe Lys Ser Glu Gly Cys Glu Val Ile Leu Val Asn
     130                 135                 140

 gtg aag act aac ctg cct agc aac atg ctc ccc aag atg gtc aac aag      480
 Val Lys Thr Asn Leu Pro Ser Asn Met Leu Pro Lys Met Val Asn Lys
 145                 150                 155                 160

 ttc ctg gac agc acc ctg cac aaa gtc ctc cct ggg ctg atg tgt ccc      528
 Phe Leu Asp Ser Thr Leu His Lys Val Leu Pro Gly Leu Met Cys Pro
                 165                 170                 175

 gcc atc gat gca gtc ctg gtg tat gtg aac agg aag tgg acc aac ctc      576
 Ala Ile Asp Ala Val Leu Val Tyr Val Asn Arg Lys Trp Thr Asn Leu
             180                 185                 190

 agt gac ccc atg cct gtg ggc cag atg ggc acc gtc aaa tat gtt ctg      624
 Ser Asp Pro Met Pro Val Gly Gln Met Gly Thr Val Lys Tyr Val Leu
         195                 200                 205

 atg tcc gca cca gcc acc aca gcc agc tac atc caa ctg gac ttc agt      672
 Met Ser Ala Pro Ala Thr Thr Ala Ser Tyr Ile Gln Leu Asp Phe Ser
     210                 215                 220

 cct gtg gtg cag cag caa aag ggc aaa acc atc aag ctt gct gat gcc      720
 Pro Val Val Gln Gln Gln Lys Gly Lys Thr Ile Lys Leu Ala Asp Ala
 225                 230                 235                 240

 ggg gag gcc ctc acg ttc cct gag ggt tat gcc aaa ggc tcg tcg cag      768
 Gly Glu Ala Leu Thr Phe Pro Glu Gly Tyr Ala Lys Gly Ser Ser Gln
                 245                 250                 255

 ctg ctg ctc cca gcc acc ttc ctc tct gca gag ctt gcc ctt ctg cag      816
 Leu Leu Leu Pro Ala Thr Phe Leu Ser Ala Glu Leu Ala Leu Leu Gln
             260                 265                 270

 aag tcc ttt cat gtg aat atc cag gat aca atg att ggt gag ctg ccc      864
 Lys Ser Phe His Val Asn Ile Gln Asp Thr Met Ile Gly Glu Leu Pro
         275                 280                 285

 cca caa acc acc aag acc ctg gct cgc ttc att cct gaa gtg gct gta      912
 Pro Gln Thr Thr Lys Thr Leu Ala Arg Phe Ile Pro Glu Val Ala Val
     290                 295                 300

 gct tat ccc aag tca aag ccc ttg acg acc cag atc aag ata aag aag      960
 Ala Tyr Pro Lys Ser Lys Pro Leu Thr Thr Gln Ile Lys Ile Lys Lys
 305                 310                 315                 320

 cct ccc aag gtc act atg aag aca ggc aag agc ctg ctg cac ctc cac     1008
 Pro Pro Lys Val Thr Met Lys Thr Gly Lys Ser Leu Leu His Leu His
                 325                 330                 335

 agc acc ctg gag atg ttc gca gct cgg tgg cgg agc aag gct cca atg     1056
 Ser Thr Leu Glu Met Phe Ala Ala Arg Trp Arg Ser Lys Ala Pro Met
             340                 345                 350

 tcc ctc ttt ctc cta gaa gtg cac ttc aat ctg aag gtc cag tac tca     1104
 Ser Leu Phe Leu Leu Glu Val His Phe Asn Leu Lys Val Gln Tyr Ser
         355                 360                 365

 gtg cat gag aac cag ctg cag atg gcc act tct ttg gac agg aga ggg     1152
 Val His Glu Asn Gln Leu Gln Met Ala Thr Ser Leu Asp Arg Arg Gly
     370                 375                 380

 aat taa ctggcttcat caccagctat ctcgaagaag cctacatccc agttgtcaat      1208
 Asn 
 385

 gatgtgcttc aagtggggct cccactcccg gactttctgg ccatgaatta caacctggct   1268

 gagctggaca tagtagagaa tgccctgatg ctggacttga agctgggctg accatggcag   1328

 gactcccctg ccagctgcct gcttaccacc aaccacctgc accccatgga ggagaccccc   1388

 tgattggagc caggtgggcc tggcccccta ccactggtgg ctgcctcctt tgacaaggag   1448

 tgaatgggtc aggcctgggc tggagccttg ccaataaaca ggagaaaggc tcttataaat   1508

 atccaaaaaa aaaaaaaa                                                 1526




      <210> 375
      <211> 1620
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(1256)

      <400> 375
 ggtttccctc tagaaataat tttgtttaac tttaagaagg agatatacat   atg cgg      56
                                                          Met Arg
                                                            1

 ggt tct cat cat cat cat cat cat ggt atg gct agc atg act ggt gga      104
 Gly Ser His His His His His His Gly Met Ala Ser Met Thr Gly Gly
           5                  10                  15

 cag caa atg ggt cgg gat ctg tac gac gat gac gat aag gat cca acc      152
 Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp Pro Thr
      20                  25                  30

 ctt gac cct ggg gca ctg ctg cgg ttg ggc atg gac atc atg aac cag      200
 Leu Asp Pro Gly Ala Leu Leu Arg Leu Gly Met Asp Ile Met Asn Gln
  35                  40                  45                  50

 gtc cag agc gcc atg gat gag agt cat atc ctg gag aag atg gca gcc      248
 Val Gln Ser Ala Met Asp Glu Ser His Ile Leu Glu Lys Met Ala Ala
                  55                  60                  65

 gag gca ggc aag aaa cag cca ggg atg aaa cct atc aag ggc atc acc      296
 Glu Ala Gly Lys Lys Gln Pro Gly Met Lys Pro Ile Lys Gly Ile Thr
              70                  75                  80

 aat ttg aag gtg aag gat gtc cag ctg ccc gtc atc aca ctg aac ttt      344
 Asn Leu Lys Val Lys Asp Val Gln Leu Pro Val Ile Thr Leu Asn Phe
          85                  90                  95

 gta cct gga gtg ggc atc ttc caa tgt gtg tcc aca ggc atg acc gtc      392
 Val Pro Gly Val Gly Ile Phe Gln Cys Val Ser Thr Gly Met Thr Val
     100                 105                 110

 act ggc aag agc ttc atg gga ggg aac atg gag atc atc gtg gcc ctg      440
 Thr Gly Lys Ser Phe Met Gly Gly Asn Met Glu Ile Ile Val Ala Leu
 115                 120                 125                 130

 aac atc aca gcc acc aac cgg ctt ctg cgg gat gag gag aca ggc ctc      488
 Asn Ile Thr Ala Thr Asn Arg Leu Leu Arg Asp Glu Glu Thr Gly Leu
                 135                 140                 145

 ccc gtg ttc aag agt gag ggc tgt gag gtc atc ctg gtc aat gtg aag      536
 Pro Val Phe Lys Ser Glu Gly Cys Glu Val Ile Leu Val Asn Val Lys
             150                 155                 160

 act aac ctg cct agc aac atg ctc ccc aag atg gtc aac aag ttc ctg      584
 Thr Asn Leu Pro Ser Asn Met Leu Pro Lys Met Val Asn Lys Phe Leu
         165                 170                 175

 gac agc acc ctg cac aaa gtc ctc cct ggg ctg atg tgt ccc gcc atc      632
 Asp Ser Thr Leu His Lys Val Leu Pro Gly Leu Met Cys Pro Ala Ile
     180                 185                 190

 gat gca gtc ctg gtg tat gtg aac agg aag tgg acc aac ctc agt gac      680
 Asp Ala Val Leu Val Tyr Val Asn Arg Lys Trp Thr Asn Leu Ser Asp
 195                 200                 205                 210

 ccc atg cct gtg ggc cag atg ggc acc gtc aaa tat gtt ctg atg tcc      728
 Pro Met Pro Val Gly Gln Met Gly Thr Val Lys Tyr Val Leu Met Ser
                 215                 220                 225

 gca cca gcc acc aca gcc agc tac atc caa ctg gac ttc agt cct gtg      776
 Ala Pro Ala Thr Thr Ala Ser Tyr Ile Gln Leu Asp Phe Ser Pro Val
             230                 235                 240

 gtg cag cag caa aag ggc aaa acc atc aag ctt gct gat gcc ggg gag      824
 Val Gln Gln Gln Lys Gly Lys Thr Ile Lys Leu Ala Asp Ala Gly Glu
         245                 250                 255

 gcc ctc acg ttc cct gag ggt tat gcc aaa ggc tcg tcg cag ctg ctg      872
 Ala Leu Thr Phe Pro Glu Gly Tyr Ala Lys Gly Ser Ser Gln Leu Leu
     260                 265                 270

 ctc cca gcc acc ttc ctc tct gca gag ctt gcc ctt ctg cag aag tcc      920
 Leu Pro Ala Thr Phe Leu Ser Ala Glu Leu Ala Leu Leu Gln Lys Ser
 275                 280                 285                 290

 ttt cat gtg aat atc cag gat aca atg att ggt gag ctg ccc cca caa      968
 Phe His Val Asn Ile Gln Asp Thr Met Ile Gly Glu Leu Pro Pro Gln
                 295                 300                 305

 acc acc aag acc ctg gct cgc ttc att cct gaa gtg gct gta gct tat     1016
 Thr Thr Lys Thr Leu Ala Arg Phe Ile Pro Glu Val Ala Val Ala Tyr
             310                 315                 320

 ccc aag tca aag ccc ttg acg acc cag atc aag ata aag aag cct ccc     1064
 Pro Lys Ser Lys Pro Leu Thr Thr Gln Ile Lys Ile Lys Lys Pro Pro
         325                 330                 335

 aag gtc act atg aag aca ggc aag agc ctg ctg cac ctc cac agc acc     1112
 Lys Val Thr Met Lys Thr Gly Lys Ser Leu Leu His Leu His Ser Thr
     340                 345                 350

 ctg gag atg ttc gca gct cgg tgg cgg agc aag gct cca atg tcc ctc     1160
 Leu Glu Met Phe Ala Ala Arg Trp Arg Ser Lys Ala Pro Met Ser Leu
 355                 360                 365                 370

 ttt ctc cta gaa gtg cac ttc aat ctg aag gtc cag tac tca gtg cat     1208
 Phe Leu Leu Glu Val His Phe Asn Leu Lys Val Gln Tyr Ser Val His
                 375                 380                 385

 gag aac cag ctg cag atg gcc act tct ttg gac agg aga ggg aat taa     1256
 Glu Asn Gln Leu Gln Met Ala Thr Ser Leu Asp Arg Arg Gly Asn 
             390                 395                 400

 ctggcttcat caccagctat ctcgaagaag cctacatccc agttgtcaat gatgtgcttc   1316

 aagtggggct cccactcccg gactttctgg ccatgaatta caacctggct gagctggaca   1376

 tagtagagaa tgccctgatg ctggacttga agctgggctg accatggcag gactcccctg   1436

 ccagctgcct gcttaccacc aaccacctgc accccatgga ggagaccccc tgattggagc   1496

 caggtgggcc tggcccccta ccactggtgg ctgcctcctt tgacaaggag tgaatgggtc   1556

 aggcctgggc tggagccttg ccaataaaca ggagaaaggc tcttataaat atccaaaaaa   1616

 aaaa                                                                1620




      <210> 376
      <211> 1237
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (108)..(743)

      <400> 376
 gcacgagggg agggtgacgc actagctctc cagttcgccc gttcctggcc tgacccccac     60

 caaggcccat accgctgtag gctcctcggg ctgcccctcg gttgaca  atg gtc tcc     116
                                                      Met Val Ser
                                                        1

 agg atg gtc tct acc atg cta tct ggc cta ctg ttt tgg ctg gca tct      164
 Arg Met Val Ser Thr Met Leu Ser Gly Leu Leu Phe Trp Leu Ala Ser
       5                  10                  15

 gga tgg act cca gca ttt gct tac agc ccc cgg acc cct gac cgg gtc      212
 Gly Trp Thr Pro Ala Phe Ala Tyr Ser Pro Arg Thr Pro Asp Arg Val
  20                  25                  30                  35

 tca gaa gca gat atc cag agg ctg ctt cat ggt gtt atg gag caa ttg      260
 Ser Glu Ala Asp Ile Gln Arg Leu Leu His Gly Val Met Glu Gln Leu
                  40                  45                  50

 ggc att gcc agg ccc cga gtg gaa tat cca gct cac cag gcc atg aat      308
 Gly Ile Ala Arg Pro Arg Val Glu Tyr Pro Ala His Gln Ala Met Asn
              55                  60                  65

 ctt gtg ggc ccc cag agc att gaa ggt gga gct cat gaa gga ctt cag      356
 Leu Val Gly Pro Gln Ser Ile Glu Gly Gly Ala His Glu Gly Leu Gln
          70                  75                  80

 cat ttg ggt cct ttt ggc aac atc ccc aac atc gtg gca gag ttg act      404
 His Leu Gly Pro Phe Gly Asn Ile Pro Asn Ile Val Ala Glu Leu Thr
      85                  90                  95

 gga gac aac att cct aag gac ttt agt gag gat cag ggg tac cca gac      452
 Gly Asp Asn Ile Pro Lys Asp Phe Ser Glu Asp Gln Gly Tyr Pro Asp
 100                 105                 110                 115

 cct cca aat ccc tgt cct gtt gga aaa aca gat gat gga tgt cta gaa      500
 Pro Pro Asn Pro Cys Pro Val Gly Lys Thr Asp Asp Gly Cys Leu Glu
                 120                 125                 130

 aac acc cct gac act gca gag ttc agt cga gag ttc cag ttg cac cag      548
 Asn Thr Pro Asp Thr Ala Glu Phe Ser Arg Glu Phe Gln Leu His Gln
             135                 140                 145

 cat ctc ttt gat ccg gaa cat gac tat cca ggc ttg ggc aag tgg aac      596
 His Leu Phe Asp Pro Glu His Asp Tyr Pro Gly Leu Gly Lys Trp Asn
         150                 155                 160

 aag aaa ctc ctt tac gag aag atg aag gga gga gag aga cga aag cgg      644
 Lys Lys Leu Leu Tyr Glu Lys Met Lys Gly Gly Glu Arg Arg Lys Arg
     165                 170                 175

 agg agt gtc aat cca tat cta caa gga cag aga ctg gat aat gtt gtt      692
 Arg Ser Val Asn Pro Tyr Leu Gln Gly Gln Arg Leu Asp Asn Val Val
 180                 185                 190                 195

 gca aag aag tct gtc ccc cat ttt tca gat gag gat aag gat cca gag      740
 Ala Lys Lys Ser Val Pro His Phe Ser Asp Glu Asp Lys Asp Pro Glu
                 200                 205                 210

 taa agag aagatgctag acgaaaaccc acattacctg ttaggcctca gcatggctta      797
 


 tgtgcacgtg taaatggagt ccctgtgaat gacagcatgt ttcttacata gataattatg    857

 gatacaaagc agctgtatgt agatagtgta ttgtcttcac accgatgatt ctgctttttg    917

 ctaaattaga ataagagctt ttttgtttct tgggttttta aaatgtgaat ctgcaatgat    977

 cataaaaatt aaaatgtgaa tgtcaacaat aaaaagcaag actatgaaag gctcagattt   1037

 cttgcagttt aaaatggtgt ctgaggttgt actattttgg ccaagtctgt agaaagctgt   1097

 catttgattt tgattatgta gttcatccag cccttgggca ttgttataca ccagtaaaga   1157

 aggctgtact caagaggagg agctgacaca tttcacttgg ctgcgtctta ataaacatga   1217

 atgcaagcaa aaaaaaaaaa                                               1237




      <210> 377
      <211> 2982
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (433)..(1797)

      <400> 377
 tggtccccag aggaacgggg cccagacagc ttcctccaca ccggaggctc acattacaac     60

 gcacagacgt cctggagggt cgcctgtcac gtcacctgtt cgcggtctcg gaatgcagcc    120

 ctgcaccttt aaatccagac tgcgtcaggg agtcccgccc cagagggagt gcggctgtcg    180

 gctggggggc gggacctgcc cttcattggc tgaaccgcgc agtattttgg cacctgtgcg    240

 ctggactcga gcgctccgat tggagttagg gcctgcttgt ctgcgtgctg cgaagtccgc    300

 ggctgccccc ggggccctag tcgttgggtt ccagggtcct tcacgttcca ttcccaggct    360

 ggtctgagct ccggggccgt ggtcccgctg cctcctccgg tcgtcgtgcg gaagctgcga    420

 cgcaggcaga cc    atg gca gag ttc tcc cag aaa cgg ggg aag cgg cgt     468
                  Met Ala Glu Phe Ser Gln Lys Arg Gly Lys Arg Arg
                    1               5                  10

 agc gac gaa ggg ctg ggc agc atg gtg gac ttc ctc ctg gcc aat gcc      516
 Ser Asp Glu Gly Leu Gly Ser Met Val Asp Phe Leu Leu Ala Asn Ala
          15                  20                  25

 cgc ctg gtg ctg ggc gtg ggc ggg gct gct gtg ctg ggc att gcc acc      564
 Arg Leu Val Leu Gly Val Gly Gly Ala Ala Val Leu Gly Ile Ala Thr
      30                  35                  40

 ctg gcc gtg aag cgg ttc att gac agg gcc act agc ccg cgg gat gag      612
 Leu Ala Val Lys Arg Phe Ile Asp Arg Ala Thr Ser Pro Arg Asp Glu
  45                  50                  55                  60

 gat gac acc aag gca gac agc tgg aag gaa ctg agc ctg ctc aag gcc      660
 Asp Asp Thr Lys Ala Asp Ser Trp Lys Glu Leu Ser Leu Leu Lys Ala
                  65                  70                  75

 aca cca cac ctg cag ccc cgg cct cca cct gct gcc ctt agc cag cca      708
 Thr Pro His Leu Gln Pro Arg Pro Pro Pro Ala Ala Leu Ser Gln Pro
              80                  85                  90

 gtg ttg ccc ttg gcc ccc tcg tcg tct gcc cca gaa ggg cct gca gaa      756
 Val Leu Pro Leu Ala Pro Ser Ser Ser Ala Pro Glu Gly Pro Ala Glu
          95                 100                 105

 act gat cct gag gtg aca cca cag ctc agc tcc cca gca ccg ctg tgt      804
 Thr Asp Pro Glu Val Thr Pro Gln Leu Ser Ser Pro Ala Pro Leu Cys
     110                 115                 120

 ctg aca ctg cag gag agg ctg ctg gcc ttc gag cgg gac cgt gtg acc      852
 Leu Thr Leu Gln Glu Arg Leu Leu Ala Phe Glu Arg Asp Arg Val Thr
 125                 130                 135                 140

 atc cca gca gcc cag gtg gct ttg gcc aaa cag ctg gct ggc gac atc      900
 Ile Pro Ala Ala Gln Val Ala Leu Ala Lys Gln Leu Ala Gly Asp Ile
                 145                 150                 155

 gcc ctg gag ctg cag gcc tac ttt cgg agc aag ttc ccg gaa ctg ccc      948
 Ala Leu Glu Leu Gln Ala Tyr Phe Arg Ser Lys Phe Pro Glu Leu Pro
             160                 165                 170

 ttt ggg gca ttc gtg cct ggg ggg ccg ctc tac gac ggg ctg cag gcg      996
 Phe Gly Ala Phe Val Pro Gly Gly Pro Leu Tyr Asp Gly Leu Gln Ala
         175                 180                 185

 ggg gct gcg gac cat gtg cgt ctc ctg gtg cca ctg gtg ctg gag ccg     1044
 Gly Ala Ala Asp His Val Arg Leu Leu Val Pro Leu Val Leu Glu Pro
     190                 195                 200

 ggc ctg tgg agc ctg gtg ccg ggc gtg gac act gtg gcg agg gac cct     1092
 Gly Leu Trp Ser Leu Val Pro Gly Val Asp Thr Val Ala Arg Asp Pro
 205                 210                 215                 220

 cgc tgc tgg gcc gtg cgc agg acg cag ctt gag ttc tgc ccc cgt ggg     1140
 Arg Cys Trp Ala Val Arg Arg Thr Gln Leu Glu Phe Cys Pro Arg Gly
                 225                 230                 235

 agc agc ccc tgg gac cgc ttc ctg gtc ggg ggc tac ctc tcc tcc cgc     1188
 Ser Ser Pro Trp Asp Arg Phe Leu Val Gly Gly Tyr Leu Ser Ser Arg
             240                 245                 250

 gtc ctg ctg gag cta ctc cgc aag gcg ctg gct gct tct gtc aac tgg     1236
 Val Leu Leu Glu Leu Leu Arg Lys Ala Leu Ala Ala Ser Val Asn Trp
         255                 260                 265

 ccg gcc att ggc agc ctt ctc ggg tgc ctg atc cgg ccc agc atg gcc     1284
 Pro Ala Ile Gly Ser Leu Leu Gly Cys Leu Ile Arg Pro Ser Met Ala
     270                 275                 280

 tcg gag gag ctg ctg ctc gag gtg cag cac gaa cgc ctg gag ctc act     1332
 Ser Glu Glu Leu Leu Leu Glu Val Gln His Glu Arg Leu Glu Leu Thr
 285                 290                 295                 300

 gtg gct gtg ctt gtg gca gtc cct ggg gtc gat gct gac gac cgc ctc     1380
 Val Ala Val Leu Val Ala Val Pro Gly Val Asp Ala Asp Asp Arg Leu
                 305                 310                 315

 ctc ttg gcc tgg ccc ctg gag ggg ctg gcg ggg aac ctc tgg ctg cag     1428
 Leu Leu Ala Trp Pro Leu Glu Gly Leu Ala Gly Asn Leu Trp Leu Gln
             320                 325                 330

 gac ctg tat cca gtg gag gct gct agg ctg cga gcc ctg gac gac cat     1476
 Asp Leu Tyr Pro Val Glu Ala Ala Arg Leu Arg Ala Leu Asp Asp His
         335                 340                 345

 gac gct ggg act cgc cgg cgg ctg ctg ctg ctg ctg tgt gct gtc tgc     1524
 Asp Ala Gly Thr Arg Arg Arg Leu Leu Leu Leu Leu Cys Ala Val Cys
     350                 355                 360

 cgt ggt tgc tcg gct ctg ggg cag cta ggc cgg ggt cac ctg acc cag     1572
 Arg Gly Cys Ser Ala Leu Gly Gln Leu Gly Arg Gly His Leu Thr Gln
 365                 370                 375                 380

 gtg gtc ctg cgt ctg ggg gag gac aac gtg gat tgg acg gag gag gcc     1620
 Val Val Leu Arg Leu Gly Glu Asp Asn Val Asp Trp Thr Glu Glu Ala
                 385                 390                 395

 ttg ggt gag cgc ttc ctg caa gcc ctg gag ctg ctc atc ggc agc ctg     1668
 Leu Gly Glu Arg Phe Leu Gln Ala Leu Glu Leu Leu Ile Gly Ser Leu
             400                 405                 410

 gag cag gcc agc ctg ccc tgc cac ttc aac ccc agc gtg aac ctc ttc     1716
 Glu Gln Ala Ser Leu Pro Cys His Phe Asn Pro Ser Val Asn Leu Phe
         415                 420                 425

 agc agc ttg cgt gag gag gag att gac gac att ggc tat gcg cta tac     1764
 Ser Ser Leu Arg Glu Glu Glu Ile Asp Asp Ile Gly Tyr Ala Leu Tyr
     430                 435                 440

 agt ggc cta cag gag ccc gag ggg ctg ctc tag gtgggtgg aaacgggtgg     1815
 Ser Gly Leu Gln Glu Pro Glu Gly Leu Leu 
 445                 450

 ttgccatgtt ttctaatgct ggggagctgc acccacctcc cttccaggga tttgaatagt   1875

 ggtttttctc tagctttttg ccagaacaaa ggagggtaca ttacttaaac ccagggcatc   1935

 aggatgtgct tgggctatgg tggccataaa ccctgagccc agagagcttg ggtcactgtc   1995

 acctgagtgc agctgggctg cctcaggcag cttggagtgc cagccattcc tgcaagcacc   2055

 gtttcagctc ttggggccaa ccccaggacc tttggctctg tccatcacca gcaaccaatc   2115

 caccaacaga atgtggtttc tgccatcctg ggcagaagct gaaggccagc ttcacatttc   2175

 tgctgagaga aggtgactta acgccttttc cggccctagc tccaggcgtt ttgaggcgtc   2235

 tggtgcctga tggtaggtat ggtgtgtttg ttctgtcccc caggggctgg agtcacctgg   2295

 tgcccctgaa ggacagattt ttggctgtta aaggatggca ttttcctgct gtcttctgtg   2355

 cgtttagttt tcttgctgag cgggagctca gtatgacttg ccacccacct gatacctcag   2415

 ggcaaggccc tttttccctc cagccaggtg agtgttttct tcaggcagct gagggtcctg   2475

 ggggagctga ggctctgtgc tgcaccccca gcccacagct ggggcatctc actggagctg   2535

 ttccaggccc cactggagag cagaggacct gatcccccac tagagaggtc cggtgtgcac   2595

 agccggcctc ccagtgtgcc aaaatgaact gctctcagct gatggctgta ttctgacttt   2655

 gaagcctgtt aagaggtagc aagggggcta gaggagggag attccacctc ccctcccaag   2715

 tgaccctcct cctgcctctg gtatccttcc ttttgaaacg aagctcagct tcgaagatgt   2775

 gaacaagaat aaaaggaaaa aattctaatg tatatataac tcaggctgga taagggagtc   2835

 ttggtgcttt catacgcagc tgttgagggt tttctgtaag tcctgtggct tgtcctggca   2895

 cttggcaaga gtgcttgagg tcaatggacg tggtagagtt actttacaaa gtagcatctt   2955

 ggccgggtgt ggtgctcgca tctgtat                                       2982




      <210> 378
      <211> 1254
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (104)..(757)

      <220>
      <221> misc_feature
      <222> (1)...(1254)
      <223> n = a,t,c or g

      <400> 378
 tcgactcact atagggaatt tggccctcga ggccaagaat tcggcacgag cctctgagtc     60

 acctaggccg cctggggctg agaagaccta accgaggggc cag  atg gct tcg acc     115
                                                  Met Ala Ser Thr
                                                    1

 ggc tta gaa ctg ctg ggc atg acc ctg gct gtg ctg ggc tgg ctg ggg      163
 Gly Leu Glu Leu Leu Gly Met Thr Leu Ala Val Leu Gly Trp Leu Gly
   5                  10                  15                  20

 acc ctg gtg tcc tgc gcc ctg ccc ctg tgg aag gtg acc gcc ttc atc      211
 Thr Leu Val Ser Cys Ala Leu Pro Leu Trp Lys Val Thr Ala Phe Ile
                  25                  30                  35

 ggc aac agc atc gtg gtg gcc cag gtg gtg tgg gag ggc ctg tgg atg      259
 Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu Gly Leu Trp Met
              40                  45                  50

 tcc tgc gtg gtg cag agc acg ggc cag atg cag tgc aag gtg tac gac      307
 Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys Lys Val Tyr Asp
          55                  60                  65

 tca ctg ctg gct ctg ccg cag gac ctg cag gcc gca cgt gcc ctc tgt      355
 Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala Arg Ala Leu Cys
      70                  75                  80

 gtc att gcc ctc ctg ctg gcc ctg ctt ggc ctc ctg gtg gcc atc aca      403
 Val Ile Ala Leu Leu Leu Ala Leu Leu Gly Leu Leu Val Ala Ile Thr
  85                  90                  95                 100

 ggt gcc cag tgt acc acg tgt gtg gag gac gaa ggt gcc aag gcc cgt      451
 Gly Ala Gln Cys Thr Thr Cys Val Glu Asp Glu Gly Ala Lys Ala Arg
                 105                 110                 115

 atc gtg ctc acc gcg ggg gtc atc ctc ctc ctc gcc ggc atc ctg gtg      499
 Ile Val Leu Thr Ala Gly Val Ile Leu Leu Leu Ala Gly Ile Leu Val
             120                 125                 130

 ctc atc cct gtg tgc tgg acg gcg cac gcc atc atc cag gac ttc tac      547
 Leu Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile Gln Asp Phe Tyr
         135                 140                 145

 aac ccc ctg gtg gct gag gcc ctc aag cgg gag ctg ggg gcc tcc ctc      595
 Asn Pro Leu Val Ala Glu Ala Leu Lys Arg Glu Leu Gly Ala Ser Leu
     150                 155                 160

 tac ctg ggc tgg gcg gcg gct gca ctg ctt atg ctg ggc ggg ggg ctc      643
 Tyr Leu Gly Trp Ala Ala Ala Ala Leu Leu Met Leu Gly Gly Gly Leu
 165                 170                 175                 180

 ctc tgc tgc acg tgc ccc ccg ccc cag gtc gag cgg ccc cgc gga cct      691
 Leu Cys Cys Thr Cys Pro Pro Pro Gln Val Glu Arg Pro Arg Gly Pro
                 185                 190                 195

 cgg ctg ggc tac tcc atc ccc tcc cgc tcg ggt gcg tct gga ctg gac      739
 Arg Leu Gly Tyr Ser Ile Pro Ser Arg Ser Gly Ala Ser Gly Leu Asp
             200                 205                 210

 aag agg gac tac gtg tga ggcgga ggtttcccct gggagcccac tgctccccac      793
 Lys Arg Asp Tyr Val 
         215

 tgcccggccc tttcgacctt ggcctgatga ccagatgccc tgctccatca caacctcctt    853

 ccccaggaaa acccactttc caaaagccca agctacacct ggctgcaggg ctgggtcagc    913

 tggcctggct gagctcttct cagtggggtc ccctttgatg ttctccccca agttgggcag    973

 cctagaggtg ttgggaaccc tggcctgccc ccacctcccc agtaattgtt tccttccgtt   1033

 gcccaggaca ctggctggcc ttccttctct tctgagccct cccctgcccc aggaaccctg   1093

 gcctcaccaa aacagcagca gctcgttggc tccaaaacca gggagcagac catgccctcc   1153

 caaccctgga gttgtcaggg agggcctgcc catcacctcc ctctccccaa catccccacc   1213

 ctcgagttgg aaataaagag catttgtana aaaaaaaaaa a                       1254




      <210> 379
      <211> 812
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (309)..(812)

      <400> 379
 cagcccctcc tgcctctttt ataagggaat tcatgaggat tatgccttca tgacccaatc     60

 acctcctcag tgcccaactt catacaacta tcagatttag ggagaaggga tacattcaga    120

 ccataacacc gttcatcaaa ggaagactgg ttaaataaac agggataagc cataaatgaa    180

 attcctaacc ccctctaaag cataaggtcc tcttccggtt ccaggcactt cgggagctgt    240

 gggttcggtg cagacatgtc caagtccaca tacaaccaca cacaaccagg cccgaaaatg    300

 gaacagaa atg gca tca aga aat ccc agt cca cgt gta tcc cat ttt ggt     350
          Met Ala Ser Arg Asn Pro Ser Pro Arg Val Ser His Phe Gly
            1               5                  10

 ttt ttt aag aag aaa ttt aaa aaa gaa aga aag aaa gaa agg aag aaa      398
 Phe Phe Lys Lys Lys Phe Lys Lys Glu Arg Lys Lys Glu Arg Lys Lys
  15                  20                  25                  30

 tcc cag tca caa aga tat gac ttt ctt aag tgg gtg aac ccc aag ttc      446
 Ser Gln Ser Gln Arg Tyr Asp Phe Leu Lys Trp Val Asn Pro Lys Phe
                  35                  40                  45

 ctg agg aac atg cac ttt gcc aag aag tac aag aag aag tgc atg aag      494
 Leu Arg Asn Met His Phe Ala Lys Lys Tyr Lys Lys Lys Cys Met Lys
              50                  55                  60

 aag atg cag gcc aac acc acc aag gcc ctg agt gca cac gcc gag gct      542
 Lys Met Gln Ala Asn Thr Thr Lys Ala Leu Ser Ala His Ala Glu Ala
          65                  70                  75

 atc aag acc ctt gta aag tcc aaa gag gtt aag ccc aag atc tca aag      590
 Ile Lys Thr Leu Val Lys Ser Lys Glu Val Lys Pro Lys Ile Ser Lys
      80                  85                  90

 ggt gtc ggc agc aaa att cat cga ctt gcc tac att gcc cac tcc aaa      638
 Gly Val Gly Ser Lys Ile His Arg Leu Ala Tyr Ile Ala His Ser Lys
  95                 100                 105                 110

 ctt ggg acg cat gct cat gcc cgc act gct aag ggt ctt agg ctg tgc      686
 Leu Gly Thr His Ala His Ala Arg Thr Ala Lys Gly Leu Arg Leu Cys
                 115                 120                 125

 tgg cca aag gcc aag aat caa acc aag gcc cag act gca gct cca gct      734
 Trp Pro Lys Ala Lys Asn Gln Thr Lys Ala Gln Thr Ala Ala Pro Ala
             130                 135                 140

 tca gtt cca gct cag gct ctc aaa agt gcc cac gcc cct aaa agg ctt      782
 Ser Val Pro Ala Gln Ala Leu Lys Ser Ala His Ala Pro Lys Arg Leu
         145                 150                 155

 cag agt aga gat ctc cat ctg caa aca tga                              812
 Gln Ser Arg Asp Leu His Leu Gln Thr 
     160                 165





      <210> 380
      <211> 6264
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (452)..(2842)

      <400> 380
 agaagtctga ccacagttcg tgtgtttgga attacggtat ccacctgacc aggctccgcc     60

 acgatgagat catcaccctg ctcaagaatg tgggcgagcg cgtggtgctg gagctcctga    120

 gaataacccc aggatcattt caaagacagt ggacgtctcc ctctacaagg agggcaatag    180

 ctttggcttt gtccttagag gaggtgccca tgaagatggg cacaagtccc gcccgcttgt    240

 cctgacctac gtgcggcccg gtggccctgc cgacagggag ggctccctga aggtgggcga    300

 caggctgctc agtgtcgatg gaatcccgct gcacggggcc agccatgcca ccgccctggc    360

 caccctgcgg cagtgcagcc acgaggcact ctttcaggtg gagtatgatg tggccacccc    420

 tgacacggtg gctaatgctt cgggaccctt g   atg gtg gaa ata gtc aag acg     472
                                      Met Val Glu Ile Val Lys Thr
                                        1               5

 cca ggg tct gcc ctg ggg atc tcg ctc acc acc acc tcc ctc cgg aac      520
 Pro Gly Ser Ala Leu Gly Ile Ser Leu Thr Thr Thr Ser Leu Arg Asn
          10                  15                  20

 aag tca gtc att acc atc gac cgc atc aag cca gcc agc gtg gtg gac      568
 Lys Ser Val Ile Thr Ile Asp Arg Ile Lys Pro Ala Ser Val Val Asp
      25                  30                  35

 agg agc gga gcc ctg cac cct gga gac cac atc ctg tcc atc gat ggc      616
 Arg Ser Gly Ala Leu His Pro Gly Asp His Ile Leu Ser Ile Asp Gly
  40                  45                  50                  55

 acc agc atg gaa cac tgc tcg ctg ctt gag gcc acc aag ctc ctg gcc      664
 Thr Ser Met Glu His Cys Ser Leu Leu Glu Ala Thr Lys Leu Leu Ala
                  60                  65                  70

 agc att tca gag aag gtg cgg ctg gag atc ctg cct gtg ccc cag agt      712
 Ser Ile Ser Glu Lys Val Arg Leu Glu Ile Leu Pro Val Pro Gln Ser
              75                  80                  85

 cag cgg cca ctg agg ccc tca gag gca gtg aaa gtg cag agg agt gag      760
 Gln Arg Pro Leu Arg Pro Ser Glu Ala Val Lys Val Gln Arg Ser Glu
          90                  95                 100

 cag ctg cac cgc tgg gac ccc tgc gtg ccc tcc tgc cac agc ccc cgg      808
 Gln Leu His Arg Trp Asp Pro Cys Val Pro Ser Cys His Ser Pro Arg
     105                 110                 115

 ccc ggc cac tgc agg atg ccc acc tgg gcc aca cct gct ggc cag gac      856
 Pro Gly His Cys Arg Met Pro Thr Trp Ala Thr Pro Ala Gly Gln Asp
 120                 125                 130                 135

 caa agc cga tcc ttg tct tca act ccc ttt tcc tcg ccg acc ttg aac      904
 Gln Ser Arg Ser Leu Ser Ser Thr Pro Phe Ser Ser Pro Thr Leu Asn
                 140                 145                 150

 cac gcc ttt tcc tgc aac aac ccc agc acc ctt ccc cgt gga tcc cag      952
 His Ala Phe Ser Cys Asn Asn Pro Ser Thr Leu Pro Arg Gly Ser Gln
             155                 160                 165

 ccc atg agt cct cga act aca atg ggg cgg agg agg cag cga aga agg     1000
 Pro Met Ser Pro Arg Thr Thr Met Gly Arg Arg Arg Gln Arg Arg Arg
         170                 175                 180

 gaa cac aag agc tcg ttg tcg cta gcc tcc agc acg gtg ggg ccg ggc     1048
 Glu His Lys Ser Ser Leu Ser Leu Ala Ser Ser Thr Val Gly Pro Gly
     185                 190                 195

 ggg cag att gtg cac acg gag acc acg gag gtc gtg ctc tgt gga gac     1096
 Gly Gln Ile Val His Thr Glu Thr Thr Glu Val Val Leu Cys Gly Asp
 200                 205                 210                 215

 ccc ctc agc ggc ttt ggc ctc cag ctc cag ggc ggc atc ttc gcc acc     1144
 Pro Leu Ser Gly Phe Gly Leu Gln Leu Gln Gly Gly Ile Phe Ala Thr
                 220                 225                 230

 gag acc ctg tcc tcc cca ccc ctc gtg tgc ttc atc gag cct gac agc     1192
 Glu Thr Leu Ser Ser Pro Pro Leu Val Cys Phe Ile Glu Pro Asp Ser
             235                 240                 245

 ccg gct gag agg tgt ggg ctg ctg cag gtg ggg gac cgt gtc ctg tcc     1240
 Pro Ala Glu Arg Cys Gly Leu Leu Gln Val Gly Asp Arg Val Leu Ser
         250                 255                 260

 atc aat ggc att gcc acc gag gac ggg act atg gag gaa gcc aac cag     1288
 Ile Asn Gly Ile Ala Thr Glu Asp Gly Thr Met Glu Glu Ala Asn Gln
     265                 270                 275

 ctc ctg cgg gac gcc gcg ctg gcc cac aag gtc gtg ctg gag gtg gag     1336
 Leu Leu Arg Asp Ala Ala Leu Ala His Lys Val Val Leu Glu Val Glu
 280                 285                 290                 295

 ttc gat gtg gcg gag tcc gtc atc cca agc agt ggc acc ttc cac gtg     1384
 Phe Asp Val Ala Glu Ser Val Ile Pro Ser Ser Gly Thr Phe His Val
                 300                 305                 310

 aag ctg ccc aag aag cgc agc gtg gag ctg ggc atc acc atc agc tcg     1432
 Lys Leu Pro Lys Lys Arg Ser Val Glu Leu Gly Ile Thr Ile Ser Ser
             315                 320                 325

 gcc agc agg aaa cga ggg gag ccc ttg atc atc tcc gac atc aag aaa     1480
 Ala Ser Arg Lys Arg Gly Glu Pro Leu Ile Ile Ser Asp Ile Lys Lys
         330                 335                 340

 ggc agc gtg gca cac agg acg ggc acc ctg gag cca ggc gac aag cta     1528
 Gly Ser Val Ala His Arg Thr Gly Thr Leu Glu Pro Gly Asp Lys Leu
     345                 350                 355

 ctg gcc att gac aat atc cgc ctg gac aac tgc ccc atg gag gac gcc     1576
 Leu Ala Ile Asp Asn Ile Arg Leu Asp Asn Cys Pro Met Glu Asp Ala
 360                 365                 370                 375

 gtg caa atc ctg cgg cag tgc gag gac ctg gtg aag ctg aag atc cgg     1624
 Val Gln Ile Leu Arg Gln Cys Glu Asp Leu Val Lys Leu Lys Ile Arg
                 380                 385                 390

 aag gac gag gac aac tct gat gag ctg gag acc aca ggt gcc gtc agc     1672
 Lys Asp Glu Asp Asn Ser Asp Glu Leu Glu Thr Thr Gly Ala Val Ser
             395                 400                 405

 tac aca gtg gag ctg aag cgc tac ggg ggt ccc ctg ggc atc acc att     1720
 Tyr Thr Val Glu Leu Lys Arg Tyr Gly Gly Pro Leu Gly Ile Thr Ile
         410                 415                 420

 tcg ggc acg gag gaa cct ttt gac ccc att gtc atc tca ggc ctc acc     1768
 Ser Gly Thr Glu Glu Pro Phe Asp Pro Ile Val Ile Ser Gly Leu Thr
     425                 430                 435

 aag cgt ggc ctg gct gag agg act ggt gcc atc cac gtg ggg gac cgc     1816
 Lys Arg Gly Leu Ala Glu Arg Thr Gly Ala Ile His Val Gly Asp Arg
 440                 445                 450                 455

 att ctg gcc atc aac aac gtt agc ctc aag ggc cgg ccg ctg agc gag     1864
 Ile Leu Ala Ile Asn Asn Val Ser Leu Lys Gly Arg Pro Leu Ser Glu
                 460                 465                 470

 gcc atc cac ctc ctg cag gtg gct gga gag acc gtc aca ctg aag atc     1912
 Ala Ile His Leu Leu Gln Val Ala Gly Glu Thr Val Thr Leu Lys Ile
             475                 480                 485

 aag aag caa cta gac cgt ccc ctc cta ccc cgc aag tcg ggc agc ctc     1960
 Lys Lys Gln Leu Asp Arg Pro Leu Leu Pro Arg Lys Ser Gly Ser Leu
         490                 495                 500

 agt gag acc agt gat gct gat gag gac cca gca gat gcc ctg aaa gga     2008
 Ser Glu Thr Ser Asp Ala Asp Glu Asp Pro Ala Asp Ala Leu Lys Gly
     505                 510                 515

 ggc ctg cca gca gcc cgc ttc tcg ccg gct gtg ccc agt gtg gac agt     2056
 Gly Leu Pro Ala Ala Arg Phe Ser Pro Ala Val Pro Ser Val Asp Ser
 520                 525                 530                 535

 gct gtg gag tct tgg gac agc tcg gcc acc gag ggt ggc ttt ggg ggc     2104
 Ala Val Glu Ser Trp Asp Ser Ser Ala Thr Glu Gly Gly Phe Gly Gly
                 540                 545                 550

 cca ggg tcc tat aca cca cag gca gca gcc cgg ggc acg acc ccc cag     2152
 Pro Gly Ser Tyr Thr Pro Gln Ala Ala Ala Arg Gly Thr Thr Pro Gln
             555                 560                 565

 gag cgg agg cct ggc tgg ctg agg ggc agc ccc cca ccc acc gag ccc     2200
 Glu Arg Arg Pro Gly Trp Leu Arg Gly Ser Pro Pro Pro Thr Glu Pro
         570                 575                 580

 cgg agg acg agc tat acc cca acc cca gct gac gag agc ttt cca gag     2248
 Arg Arg Thr Ser Tyr Thr Pro Thr Pro Ala Asp Glu Ser Phe Pro Glu
     585                 590                 595

 gag gag gag ggg gat gat tgg gag ccg cca acg agc cca gcc cct ggc     2296
 Glu Glu Glu Gly Asp Asp Trp Glu Pro Pro Thr Ser Pro Ala Pro Gly
 600                 605                 610                 615

 cct gcc cga gag gag ggc ttc tgg cgc atg ttt gga gaa gct ctc gaa     2344
 Pro Ala Arg Glu Glu Gly Phe Trp Arg Met Phe Gly Glu Ala Leu Glu
                 620                 625                 630

 gac ctg gag tca tgt ggt cag tca gag ctg ctg agg gaa ctg gag gca     2392
 Asp Leu Glu Ser Cys Gly Gln Ser Glu Leu Leu Arg Glu Leu Glu Ala
             635                 640                 645

 tcc atc atg acg ggc acc gtg cag agg gtg gcc ctc gag ggc agg cct     2440
 Ser Ile Met Thr Gly Thr Val Gln Arg Val Ala Leu Glu Gly Arg Pro
         650                 655                 660

 ggc cac cgg cct tgg cag agg ggc cgg gag gta cga gcc tct cct gca     2488
 Gly His Arg Pro Trp Gln Arg Gly Arg Glu Val Arg Ala Ser Pro Ala
     665                 670                 675

 gaa atg gag gag ctg ttg ctg cct aca ccc ttg gag atg cac aag gtg     2536
 Glu Met Glu Glu Leu Leu Leu Pro Thr Pro Leu Glu Met His Lys Val
 680                 685                 690                 695

 acc ctg cac aag gac ccc atg cgg cat gac ttt ggt ttc agc gtc tca     2584
 Thr Leu His Lys Asp Pro Met Arg His Asp Phe Gly Phe Ser Val Ser
                 700                 705                 710

 gat ggc ctc ctg gaa aaa ggt gtc tat gtc cac act gtg cgc cct gat     2632
 Asp Gly Leu Leu Glu Lys Gly Val Tyr Val His Thr Val Arg Pro Asp
             715                 720                 725

 ggg cca gcc cac cgt gga ggc ctc cag ccc ttc gac agg gtc ctg cag     2680
 Gly Pro Ala His Arg Gly Gly Leu Gln Pro Phe Asp Arg Val Leu Gln
         730                 735                 740

 gtc aac cac gtc cgt aca cgg gac ttc gac tgc tgc ctg gcg gtg cca     2728
 Val Asn His Val Arg Thr Arg Asp Phe Asp Cys Cys Leu Ala Val Pro
     745                 750                 755

 ctc ctg gcc gag gcg ggt gat gtc ttg gag ctg atc atc agc cgc aag     2776
 Leu Leu Ala Glu Ala Gly Asp Val Leu Glu Leu Ile Ile Ser Arg Lys
 760                 765                 770                 775

 ccg cac acg gca cac agc agc cgg gcc ccc cga tcg cca ggc ccc agc     2824
 Pro His Thr Ala His Ser Ser Arg Ala Pro Arg Ser Pro Gly Pro Ser
                 780                 785                 790

 agt ccc cgg atg ctc tga agtcag catgtgggcc gaactcctaa ggggccaccc     2878
 Ser Pro Arg Met Leu 
             795

 aggcagatcc tggctcccag acacgtagct gggctggaga agcggccacc cactcattca   2938

 tctgttggtc tggcagactc tgagcctggg atgatgcttg gtctctgttc cccaggtctg   2998

 tggtgactgg ggtgccaggc agggaggtcc tgccctagtt ggagtgacag ctggggtctc   3058

 tcgccaagtt gggtctccaa gatgcccaga ggagcctccc ttaagaaggg ttggcacagg   3118

 ctgctcagcc gagaggagag aggcctgggg gctgtcccag gtctctgtgg ggcctccttg   3178

 gagaggtcga agatgtaggg agcacttcct cccagcaaag ccatggagct ggaatgagct   3238

 gcaaggagga gtgagttctc ggtcacagga ggtgagcagg caggagctgg ataccccagc   3298

 gcagtcatgc attggggtat gaggcattcc catgatgcgt gcacacgcgc ttgggggttg   3358

 gcttcctgat ggggagccac ttcatctaga gactcggcca ccaggaagga tgctgcttcg   3418

 gatgggagcc cagctccttc gcttctccag aataggggtt tggggcttgc tagtcctgag   3478

 attctgagat tcccagaatc tggtccccac ttatgagact cttaagttgg ggcgtctggg   3538

 atcccaggaa gtgctggccc tttgattctg aaagtgggtg attctttgat ttcagcatct   3598

 cagtctgaag cttctgggac ttgagactgt ggttctgggc ccattgggca ggctctatgg   3658

 gccttgggct ctcagccctc ctgcttcttc tgtaggccgt gtggccactg acccatctgc   3718

 acgtccgctc agcccaagcc cctccatgtg ggaggggtca ttttggggca aaagaccctg   3778

 gagcttccat tcacctgcca tccagtgaaa attgaaaagc gatggacgca ggacctgtga   3838

 ggcggtagcg ctcctcttta cagccagatc agtggaggaa gaggagaaag agggagggag   3898

 atgggagaga aatgggccag agaaaaagat gggacactct tgcccagtgg agggtgtcca   3958

 aagtgcttat tcaaagaagt ctattcccac ttgaaatctg gaagcaccag catcccttaa   4018

 aatcattgtc ctcagtgtcc acaaatcaga gaccctcttc attttgagaa gggtgtgggc   4078

 ctcccctggt ggtctagtga gtggtgcctg ggatggagtg ggcgggcagg tgtagccagg   4138

 gctggggatg tgctttgcct ggcccagttc tcacaggggt ctcaggaaaa cggggcaccc   4198

 actcccacct ccatctgtct ccaacctggg gtccctggag gccagaaaag tgctcttcca   4258

 tttgagggaa cagatgagga gtcaagaggt ctgttctttt caccctgggt ctgttacctg   4318

 tttgctgtgt gaccctgtct gggttggacc cccagcccct ctggacgatc acgggtggac   4378

 agtctgagca gacacaggcc tcctggtcag ggccggaacc atctctgccg acccaccaag   4438

 gcccccttgg ggacctgccc acgctgtctc ctggaggcct gcctccctta cccctcccct   4498

 ccacttcgct gggctctgcc ccttggtgcc ctccctgagg gccctgcatg cttgtgcctg   4558

 gggtgctcag cgcctctgct atcttggatt cccgtgtact cagcccagag tgaaagggca   4618

 ctgtctacct gtcacagggc accaagtgaa agccaagagc cctcactttt gagggtgagg   4678

 gacagcacag cagaggtgtg gcttctggat gcaagcagcc atagctgtgt gaccttggac   4738

 aggtggctca gcctctctgg acctctgcta agcaacaggg ctggacagga cacactctca   4798

 gggcctctcg gcttgggaaa actgcattga ctccaggact ccaggcgagg gaagatgcac   4858

 ccgactctaa ctaatacccc cctccctcct cgggctgagg cctctgccat tctcccaaaa   4918

 gtatgcaatc aggcccgcgg tgggcctccc agccatgccg gcctcctcat atgcaatatt   4978

 tcttctggct tctcatgggg atggttcatc cccgacttga aatttcctga cacctttccc   5038

 cagtgagcgc cctgcctgcc tatgcatttt gggaacagcc cctgtgacat gtccccttcc   5098

 acctgccctc tcccccaaag ctgtattttt ctctggctga gattagaaca cattccttgt   5158

 aaagtatttt tctacatcgg gttttcttag ggctctcggg aagcacaagg ggctgtattg   5218

 caaaggccgc ttatggtctg tttggggccc tcgtctaagt ctttgtccca ccaggggttg   5278

 cagtggcttg ggggtaggtg ccatggggat gattttttaa aataaaatta tttaaatcca   5338

 cctagagtag aagtttgctt tttaaaaaaa tcatggattg gcaagagtca gcttctgtat   5398

 gggtctggtg acatctcacc tgcttttgat gattcattaa ttcaaaaagt ttgccatttg   5458

 cttccatcat ccagcccctg ggcaacatga atcagacaga tttaggtcat gtctgcacat   5518

 tctggtggca ggcagacaat caacaagtaa gcaaataaat aattatttca aaaggcatca   5578

 agtgcaacaa agaaaacaag ggagtaacgg gatagaggga ccagggtgag gggctttagc   5638

 tcacaatatt aggaggggtt tctctcaaga ggcgacattt gcaatgagac ctgaagacag   5698

 gagccagcct ccatggagac ctggaggaag agtgtctcag gcagcgggca cagctagtgc   5758

 aaaggccctg agataggaac gagtttgacg gtctcaagga agagaaagaa ggcctgggag   5818

 gggaatgggg ctggagacta ggttggaggt agcaggaatc agtcgtgaag gcttgggtag   5878

 ggggagcaaa tttgattctc tgcgcagcag aaagccagag gcaggcagtg gtgcctgcat   5938

 atggagtctc tttagcccag gttgggaagg tagtggcagg agggcagcct cgggtctggc   5998

 tgctgccctg gagtgtccag agagtgtcta gggcaggtga gctacagggt ctgggaccca   6058

 gaggccaggg ccaggcccca ctggggaggc cacagttctg tgagcagagg aagagcttct   6118

 ttccaggaag cgagtactct gtcttgggag tggtgtaggc agggggaagg ccaagggagg   6178

 cagcaggcct tgctctaagc gctttgcaag agcttgctgg atcctcccaa gagcctttgg   6238

 aggtgggctc tattcctgtc ccatca                                        6264




      <210> 381
      <211> 1907
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1665)

      <400> 381
  atg tca act gag aca gaa ctt caa gta gct gtg aaa acc agc gcc aag      48
  Met Ser Thr Glu Thr Glu Leu Gln Val Ala Val Lys Thr Ser Ala Lys
    1               5                  10                  15

 aaa gac tcc aga aag aaa ggt cag gat cgc agt gaa gcc act ttg ata       96
 Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu Ala Thr Leu Ile
              20                  25                  30

 aag agg ttt aaa ggt gaa ggg gtc cgg tac aaa gcc aaa ttg atc ggg      144
 Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala Lys Leu Ile Gly
          35                  40                  45

 att gat gaa gtt tcc gca gct cgg gga gac aag tta tgt caa gat tcc      192
 Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu Cys Gln Asp Ser
      50                  55                  60

 atg atg aaa ctc aag ggc gtt gtt gct ggc gct cgt tcc aaa gga gaa      240
 Met Met Lys Leu Lys Gly Val Val Ala Gly Ala Arg Ser Lys Gly Glu
  65                  70                  75                  80

 cac aaa cag aaa atc ttt tta acc atc tcc ttt gga gga atc aaa atc      288
 His Lys Gln Lys Ile Phe Leu Thr Ile Ser Phe Gly Gly Ile Lys Ile
                  85                  90                  95

 ttt gat gag aag aca ggg gcc ctt cag cat cat cat gct gtt cat gaa      336
 Phe Asp Glu Lys Thr Gly Ala Leu Gln His His His Ala Val His Glu
             100                 105                 110

 ata tcc tac att gca aag gac att aca gat cac cgg gcc ttt gga tat      384
 Ile Ser Tyr Ile Ala Lys Asp Ile Thr Asp His Arg Ala Phe Gly Tyr
         115                 120                 125

 gtt tgt ggg aag gaa ggg aat cac aga ttt gtg gcc ata aaa aca gcc      432
 Val Cys Gly Lys Glu Gly Asn His Arg Phe Val Ala Ile Lys Thr Ala
     130                 135                 140

 cag gcg gct gaa cct gtt att ctg gac ttg aga gat ctc ttt caa ctc      480
 Gln Ala Ala Glu Pro Val Ile Leu Asp Leu Arg Asp Leu Phe Gln Leu
 145                 150                 155                 160

 att tat gaa ttg aag caa aga gaa gaa tta gaa aaa aag gca caa aag      528
 Ile Tyr Glu Leu Lys Gln Arg Glu Glu Leu Glu Lys Lys Ala Gln Lys
                 165                 170                 175

 gat aag cag tgt gaa caa gct gtg tac cag aca ata ttg gaa gag gat      576
 Asp Lys Gln Cys Glu Gln Ala Val Tyr Gln Thr Ile Leu Glu Glu Asp
             180                 185                 190

 gtt gaa gat cct gtg tac cag tac att gtg ttt gag gct gga cac gag      624
 Val Glu Asp Pro Val Tyr Gln Tyr Ile Val Phe Glu Ala Gly His Glu
         195                 200                 205

 cca atc cgt gat ccc gaa acg gaa gaa aac att tat cag gtt ccc acc      672
 Pro Ile Arg Asp Pro Glu Thr Glu Glu Asn Ile Tyr Gln Val Pro Thr
     210                 215                 220

 agc caa aag aag gaa ggt gtt tat gat gtg cca aaa agt caa cct gta      720
 Ser Gln Lys Lys Glu Gly Val Tyr Asp Val Pro Lys Ser Gln Pro Val
 225                 230                 235                 240

 agt gct gtg acc caa tta gaa ctt ttt ggg gac atg tcc aca ccc cct      768
 Ser Ala Val Thr Gln Leu Glu Leu Phe Gly Asp Met Ser Thr Pro Pro
                 245                 250                 255

 gat ata acc tct ccc ccc act cct gca act cca ggt gat gcc ttt atc      816
 Asp Ile Thr Ser Pro Pro Thr Pro Ala Thr Pro Gly Asp Ala Phe Ile
             260                 265                 270

 cca tct tca tct cag acc ctt cca gcg agt gca gat gtg ttt agt tct      864
 Pro Ser Ser Ser Gln Thr Leu Pro Ala Ser Ala Asp Val Phe Ser Ser
         275                 280                 285

 gta cct ttc ggc act gct gct gta ccc tca ggt tac gtt gca atg ggc      912
 Val Pro Phe Gly Thr Ala Ala Val Pro Ser Gly Tyr Val Ala Met Gly
     290                 295                 300

 gct gtc ctc ccg tcc ttc tgg ggt cag cag ccc ctc gtc caa cag cag      960
 Ala Val Leu Pro Ser Phe Trp Gly Gln Gln Pro Leu Val Gln Gln Gln
 305                 310                 315                 320

 atg gtc atg ggt gcc cag cca cca gtc gct cag gtg atg ccg ggg gct     1008
 Met Val Met Gly Ala Gln Pro Pro Val Ala Gln Val Met Pro Gly Ala
                 325                 330                 335

 cag ccc atc gca tgg ggc cag ccg ggt ctc ttt cct gcc act cag cag     1056
 Gln Pro Ile Ala Trp Gly Gln Pro Gly Leu Phe Pro Ala Thr Gln Gln
             340                 345                 350

 ccc tgg cca act gtg gcc ggg cag ttt ccg cca gcc gcc ttc atg ccc     1104
 Pro Trp Pro Thr Val Ala Gly Gln Phe Pro Pro Ala Ala Phe Met Pro
         355                 360                 365

 aca caa act gtt atg cct ttg cca gct gcc atg ttc caa ggt ccc ctc     1152
 Thr Gln Thr Val Met Pro Leu Pro Ala Ala Met Phe Gln Gly Pro Leu
     370                 375                 380

 acc ccc ctt gcc acc gtc cca ggc acg agt gac tcc acc agg tca agt     1200
 Thr Pro Leu Ala Thr Val Pro Gly Thr Ser Asp Ser Thr Arg Ser Ser
 385                 390                 395                 400

 cca cag acc gac aag ccc agg cag aaa atg ggc aaa gaa acg ttt aag     1248
 Pro Gln Thr Asp Lys Pro Arg Gln Lys Met Gly Lys Glu Thr Phe Lys
                 405                 410                 415

 gat ttc cag atg gcc cag cct ccg ccc gtg ccc tcc cgc aaa ccc gac     1296
 Asp Phe Gln Met Ala Gln Pro Pro Pro Val Pro Ser Arg Lys Pro Asp
             420                 425                 430

 cag ccc tcc ctc acc tgt acc tca gag gcc ttc tcc agt tac ttc aac     1344
 Gln Pro Ser Leu Thr Cys Thr Ser Glu Ala Phe Ser Ser Tyr Phe Asn
         435                 440                 445

 aaa gtc ggg gtg gca cag gat aca gac gac tgt gat gac ttt gac atc     1392
 Lys Val Gly Val Ala Gln Asp Thr Asp Asp Cys Asp Asp Phe Asp Ile
     450                 455                 460

 tcc cag ttg aat ttg acc cct gtg act tct acc aca cca tcg acc aac     1440
 Ser Gln Leu Asn Leu Thr Pro Val Thr Ser Thr Thr Pro Ser Thr Asn
 465                 470                 475                 480

 tca cct cca acc cca gcc cct aga cag agc tct cca tcc aaa tca tct     1488
 Ser Pro Pro Thr Pro Ala Pro Arg Gln Ser Ser Pro Ser Lys Ser Ser
                 485                 490                 495

 gca tcc cat gcc agt gat cct acc aca gat gac atc ttt gaa gag ggc     1536
 Ala Ser His Ala Ser Asp Pro Thr Thr Asp Asp Ile Phe Glu Glu Gly
             500                 505                 510

 ttt gaa agt ccc agc aaa agc gaa gag caa gaa gct cct gat gga tca     1584
 Phe Glu Ser Pro Ser Lys Ser Glu Glu Gln Glu Ala Pro Asp Gly Ser
         515                 520                 525

 cag gcc tca tcc aac agt gat cca ttt ggt gag ccc agt ggg gag ccc     1632
 Gln Ala Ser Ser Asn Ser Asp Pro Phe Gly Glu Pro Ser Gly Glu Pro
     530                 535                 540

 agt ggt gat aat ata agt ccg cag ggc cgg tag ctaagatt agcgcaggtc     1683
 Ser Gly Asp Asn Ile Ser Pro Gln Gly Arg 
 545                 550

 tgggagccag agcctctgta cgcgcagatc aacagaccta agaaatagca tcgatgcgag   1743

 ctcgtggtgg gtgctcaaga ctggcatgga catcagcatc acgacaggct ctcttgtatt   1803

 ctttcacctc ttcccacaag aaattcatga ttgcccaatg gaactcgctc agaagaggga   1863

 actaagcatt tttggcaacc aatggcagaa ataaatggca gcac                    1907




      <210> 382
      <211> 1882
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (171)..(1151)

      <400> 382
 ggaggagcgg ggccgggagc tgcgaggagc cctccagacg tcgccgagcg cgagggcggg     60

 cgtgctcgga gtggtcgctc gtcagccgcc gcccctcagt ctccgcactt gcaggtcccc    120

 tccctctccg ccgggacgcg ggagagcccg gctcgcggcg ggggcggcca   atg cga     176
                                                          Met Arg
                                                            1

 aac tgg ctg gtg ctg ctg tgc ccg tgt gtg ctc ggg gcc gcg ctg cac      224
 Asn Trp Leu Val Leu Leu Cys Pro Cys Val Leu Gly Ala Ala Leu His
           5                  10                  15

 ctc tgg ctg cgg ctg cgc tcc ccg ccg ccc gcc tgc gcc tcc ggg gcc      272
 Leu Trp Leu Arg Leu Arg Ser Pro Pro Pro Ala Cys Ala Ser Gly Ala
      20                  25                  30

 ggc cct gca ggt gga gtc tca ctc ttg ttg ccc agg ctg gag tgc aat      320
 Gly Pro Ala Gly Gly Val Ser Leu Leu Leu Pro Arg Leu Glu Cys Asn
  35                  40                  45                  50

 ggc gcg gtc tcg gct cac ccc aac ctc cac ctc ccg ggt tca aga gat      368
 Gly Ala Val Ser Ala His Pro Asn Leu His Leu Pro Gly Ser Arg Asp
                  55                  60                  65

 tct cct gcc tca gcc tcc caa gta gct ggg ata aca gat cag ttg gcc      416
 Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Ile Thr Asp Gln Leu Ala
              70                  75                  80

 tta ttt cct cag tgg aaa tct act cac tat gat gtg gta gtt ggc gtg      464
 Leu Phe Pro Gln Trp Lys Ser Thr His Tyr Asp Val Val Val Gly Val
          85                  90                  95

 ttg tca gct cgc aat aac cat gaa ctt cga aac gtg ata aga agc acc      512
 Leu Ser Ala Arg Asn Asn His Glu Leu Arg Asn Val Ile Arg Ser Thr
     100                 105                 110

 tgg atg aga cat ttg cta cag cat ccc aca tta agt caa cgt gtg ctt      560
 Trp Met Arg His Leu Leu Gln His Pro Thr Leu Ser Gln Arg Val Leu
 115                 120                 125                 130

 gtg aag ttc ata ata ggt gct cat ggc tgt gaa gtg cct gtg gaa gac      608
 Val Lys Phe Ile Ile Gly Ala His Gly Cys Glu Val Pro Val Glu Asp
                 135                 140                 145

 agg gaa gat cct tat tcc tgt aaa cta ctc aac atc aca aat cca gtt      656
 Arg Glu Asp Pro Tyr Ser Cys Lys Leu Leu Asn Ile Thr Asn Pro Val
             150                 155                 160

 ttg aat cag gaa att gaa gcg ttc agt ctg tcc gaa gac act tca tcg      704
 Leu Asn Gln Glu Ile Glu Ala Phe Ser Leu Ser Glu Asp Thr Ser Ser
         165                 170                 175

 ggg ctg cct gag gat cga gtt gtc agc gtg agt ttc cga gtt ctc tac      752
 Gly Leu Pro Glu Asp Arg Val Val Ser Val Ser Phe Arg Val Leu Tyr
     180                 185                 190

 ccc atc gtt att acc agt ctt gga gtg ttc tac gat gcc aat gat gtg      800
 Pro Ile Val Ile Thr Ser Leu Gly Val Phe Tyr Asp Ala Asn Asp Val
 195                 200                 205                 210

 ggt ttc cag agg aac atc act gtc aaa ctt tat cag gca gaa caa gag      848
 Gly Phe Gln Arg Asn Ile Thr Val Lys Leu Tyr Gln Ala Glu Gln Glu
                 215                 220                 225

 gag gcc ctc ttc att gct cgc ttc agt cct cca agc tgt ggt gtg cag      896
 Glu Ala Leu Phe Ile Ala Arg Phe Ser Pro Pro Ser Cys Gly Val Gln
             230                 235                 240

 gtg aac aag ctg tgg tac aag ccc gtg gaa caa ttc atc tta cca gag      944
 Val Asn Lys Leu Trp Tyr Lys Pro Val Glu Gln Phe Ile Leu Pro Glu
         245                 250                 255

 agc ttt gaa ggt aca atc gtg tgg gag agc caa gac ctc cac ggc ctt      992
 Ser Phe Glu Gly Thr Ile Val Trp Glu Ser Gln Asp Leu His Gly Leu
     260                 265                 270

 gtg tca aga aat ctc cac aaa gtg aca gtg aat gat gga ggg gga gtt     1040
 Val Ser Arg Asn Leu His Lys Val Thr Val Asn Asp Gly Gly Gly Val
 275                 280                 285                 290

 ctc aga gtc att aca gct ggg gag ggt gca ttg cct cat gaa ttc ttg     1088
 Leu Arg Val Ile Thr Ala Gly Glu Gly Ala Leu Pro His Glu Phe Leu
                 295                 300                 305

 gaa ggt gtg gag gga gtt gca ggt ggt ttt ata tat act att cag ggt     1136
 Glu Gly Val Glu Gly Val Ala Gly Gly Phe Ile Tyr Thr Ile Gln Gly
             310                 315                 320

 aag ttt gct agt tga aacttgaaaa gtacactgaa tgtcttacac ttaatcttta     1191
 Lys Phe Ala Ser 
         325

 tacttgagag aaaaggattt tttctttttt gtcttttaaa aaactttatt cagataaaat   1251

 tcaccctttt aaagtggttc agtggtttta gtgtattctt agagttctac aaccggctcc   1311

 acctcccaaa aggaaacccc acacccatta gcagttactc ctcattctta cctccccaac   1371

 cccccacccc ctaacaacta ctgatgcact ttctttctct atggatttgc ctgttttgaa   1431

 catttcacat aaatggaaat gcacagtacg tactctgtgt gtcagtttct ttgctgtaac   1491

 atgtgttcca ggtctgtcca ttttgtatgt atcagtactt cttttttatg atcatataat   1551

 attctattgc atcgatatgc cctattttat tcattcatta atggatggac atttagattg   1611

 cttctacttt ttgaatatga ataattctgt agtaaacatg taggtacaag tttttgtgtg   1671

 gtcatatatt tccatttctc ttaaatgtct aggagtagaa gacctgggtc atataattgt   1731

 gtgtttaatc acttgaggca ctgccaggtt gttttctaaa gcagcagccc actttacatt   1791

 tccatagtca gtatatgagg attctagttt ctccatattc ttgtcaacac ttaataaatt   1851

 gtctgtcttt taaaatatac caaaaaaaaa a                                  1882




      <210> 383
      <211> 3462
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1164)..(2240)

      <220>
      <221> misc_feature
      <222> (1)...(3462)
      <223> n = a,t,c or g

      <400> 383
 taagcttgga nccgcatatt tttttttttt tttttttttt tttaggaaag aagggagttt     60

 atcactgtaa ctggatacag ggagaaggct ggagataatt ccagcagacc aactcaaagt    120

 gctacaattt tcttactgtt tatataggtt ggggttatgt gcctacatgc agtacagcaa    180

 tcacctaagt ctactggtaa ctaattttgt tccaaggaga aggtcagagg caaaaaaaat    240

 gcttgctaag tccgattaaa aggggcccag tgccttcaag gcctgtctac tgtggtaccg    300

 gagtgattat ttcgattgta tctcctttac agcttggtcc agagagctgc cttagactat    360

 ccaattgatc tattcaaaca gctgcctgtt cccttaactt gtcttcagat tttgtcgacc    420

 cgagatgggt cctggcacta ggaatgtaaa accgttccta ttattttggc ttgctccagc    480

 aaaagagaag cccatgcaag gctcctgctg accatgtttc atttctagct ttgatgtctg    540

 ggcactgatt tccctagatt taactatgtg ctcaatggta aggcagtgct gtggaaatct    600

 gtctgtgtaa ctggggtgct atgcaggcct gtctgggtga ctgtcaggga caactgtcct    660

 accacaccaa ggacacagcc ctgggggtgc ttttcttcat agccaaagaa gctgcaggaa    720

 acccacccta gtgggacaaa gaccaatgca gggtcagtcc ccacagccag gtgatgcaaa    780

 caggctggac gtgggccgcc tcccctccag cttgacttgt gacagggaaa ccaatgcagc    840

 agcagcaggg ccaccagagt cctgtcctgg ggacaggctt ccttccagcg ggcggggagt    900

 gggtgctcct gccagaccag cctggcttcc acggttccag agaccctgtt ctccctcagc    960

 ccagtccccg cccccactcc ttggctttat gagttcattg gctgaagtca cccggagaca   1020

 atgctgagtg ttccacccct gagtcgaagc ccagcccagg gcagcccagc cagacgcctc   1080

 cggtagtgta aatgaggaca atgcctgctg gcccacatga cggggggatg tagacggcag   1140

 cggcgccagt cgctcctggc acc    atg gac gat gcc aca gtc cta agg aag    1190
                              Met Asp Asp Ala Thr Val Leu Arg Lys
                                1               5

 aag ggt tac atc gta ggc atc aat ctt ggc aag ggt tcc tac gca aaa     1238
 Lys Gly Tyr Ile Val Gly Ile Asn Leu Gly Lys Gly Ser Tyr Ala Lys
  10                  15                  20                  25

 gtc aaa tct gcc tac tct gag cgc ctc aag ttc aat gtg gct gtc aag     1286
 Val Lys Ser Ala Tyr Ser Glu Arg Leu Lys Phe Asn Val Ala Val Lys
                  30                  35                  40

 atc atc gcc cgc aag aaa aca cct act gac ttt gtg gag aga ttc ctt     1334
 Ile Ile Ala Arg Lys Lys Thr Pro Thr Asp Phe Val Glu Arg Phe Leu
              45                  50                  55

 cct cgg gag atg gac atc ctg gca act gtc aac cac ggc tcc atc atc     1382
 Pro Arg Glu Met Asp Ile Leu Ala Thr Val Asn His Gly Ser Ile Ile
          60                  65                  70

 aag act tac gag atc ttt gag acc tct gac gga cgg atc tac atc atc     1430
 Lys Thr Tyr Glu Ile Phe Glu Thr Ser Asp Gly Arg Ile Tyr Ile Ile
      75                  80                  85

 atg gag ctt ggc gtc cag ggc gac ctc ctc gag ttc atc aag tgc cag     1478
 Met Glu Leu Gly Val Gln Gly Asp Leu Leu Glu Phe Ile Lys Cys Gln
  90                  95                 100                 105

 gga gcc ctg cat gag gac gtg gca cgc aag atg ttc cga cag ctc tcc     1526
 Gly Ala Leu His Glu Asp Val Ala Arg Lys Met Phe Arg Gln Leu Ser
                 110                 115                 120

 tcc gcc gtc aag tac tgc cac gac ctg gac atc gtc cac cgg gac ctc     1574
 Ser Ala Val Lys Tyr Cys His Asp Leu Asp Ile Val His Arg Asp Leu
             125                 130                 135

 aag tgc gag aac ctt ctc ctc gac aag gac ttc aac atc aag ctg tct     1622
 Lys Cys Glu Asn Leu Leu Leu Asp Lys Asp Phe Asn Ile Lys Leu Ser
         140                 145                 150

 gac ttt ggc ttc tcc aag cgc tgc ctg cgg gac agc aat ggg cgc atc     1670
 Asp Phe Gly Phe Ser Lys Arg Cys Leu Arg Asp Ser Asn Gly Arg Ile
     155                 160                 165

 atc ctc agc aag acc ttc tgc ggg tcg gca gca tat gca gcc ccc gag     1718
 Ile Leu Ser Lys Thr Phe Cys Gly Ser Ala Ala Tyr Ala Ala Pro Glu
 170                 175                 180                 185

 gtg ctg cag agc atc ccc tac cag ccc aag gtg tat gac atc tgg agc     1766
 Val Leu Gln Ser Ile Pro Tyr Gln Pro Lys Val Tyr Asp Ile Trp Ser
                 190                 195                 200

 ctg ggc gtg atc ctg tac atc atg gtc tgc ggc tcc atg ccc tat gac     1814
 Leu Gly Val Ile Leu Tyr Ile Met Val Cys Gly Ser Met Pro Tyr Asp
             205                 210                 215

 gac tcc gac atc agg aag atg ctg cgt atc cag aag gag cac cgt gtg     1862
 Asp Ser Asp Ile Arg Lys Met Leu Arg Ile Gln Lys Glu His Arg Val
         220                 225                 230

 gac ttc ccg cgc tcc aag aac ctg acc tgc gag tgc aag gac ctc atc     1910
 Asp Phe Pro Arg Ser Lys Asn Leu Thr Cys Glu Cys Lys Asp Leu Ile
     235                 240                 245

 tac cgc atg ctg cag ccc gac gtc agc cag cgg ctc cac atc gat gag     1958
 Tyr Arg Met Leu Gln Pro Asp Val Ser Gln Arg Leu His Ile Asp Glu
 250                 255                 260                 265

 atc ctc agc cac tcg tgg ctg cag ccc ccc aag ccc aaa gcc acg tct     2006
 Ile Leu Ser His Ser Trp Leu Gln Pro Pro Lys Pro Lys Ala Thr Ser
                 270                 275                 280

 tct gcc tcc ttc aag agg gag ggg gag ggc aag tac cgc gct gag tgc     2054
 Ser Ala Ser Phe Lys Arg Glu Gly Glu Gly Lys Tyr Arg Ala Glu Cys
             285                 290                 295

 aaa ctg gac acc aag aca ggc ttg agg ccc gac cac cgg ccc gac cac     2102
 Lys Leu Asp Thr Lys Thr Gly Leu Arg Pro Asp His Arg Pro Asp His
         300                 305                 310

 aag ctt gga gcc aaa acc cag cac cgg ctg ctg gtg gtg ccc gag aac     2150
 Lys Leu Gly Ala Lys Thr Gln His Arg Leu Leu Val Val Pro Glu Asn
     315                 320                 325

 gag aac agg atg gag gac agg ctg gcc gag acc tcc agg gcc aaa gac     2198
 Glu Asn Arg Met Glu Asp Arg Leu Ala Glu Thr Ser Arg Ala Lys Asp
 330                 335                 340                 345

 cat cac atc tcc gga gct gag gtg ggg aaa gca agc acc tag catgaca     2247
 His His Ile Ser Gly Ala Glu Val Gly Lys Ala Ser Thr 
                 350                 355

 atggccccgt tgtgtgtggt gggggtcggg gttggggggc atggtgcagt cggccttcac   2307

 gtaaactaag taggcaggta ggatctgaag aaggcacagg tgcaagtaaa attcgtcaat   2367

 taaaccacta ttttgattac gttccattag ctttcttcca cttagcagca aagacgttcc   2427

 ttactgacca ccaaataaac cacagggtgt gtgcaagcat caagagtgcc cagtgaggag   2487

 tgtttttctc tgggactcag ccaaccgccc cacctgacac acagtggtct ccggcctagg   2547

 agcacaggac agatgctcag gtacaggcag aatcacagtg tggcctggcc ttgtggggga   2607

 caagagggcc tctgccaggg tccacccacc aggcccacac tgtctccctc tgacctggcc   2667

 ttgtccccaa tgccctgggg ctggccagct ccagtggtcc acgactcccc ctggcttcct   2727

 gcagttcagc cccctctgac ctacccccac tccctcacaa tccctcgctc agcatcctcc   2787

 tcttcctcta tttcctggag tcatgtgaga tttctgtcct cagccctcaa gttccctgcc   2847

 ctgtcctcca ggggcagccc cagctgagac ctccccgtgt gccctcccca cccagtggct   2907

 cttcaagctg ctcagcagcc cttgatgatg gcacactggc cggtcttttg tgcttcctgc   2967

 tgggtcaccc attgctccca aagcatgcgg cccacttgct ggccaagtgc tccaggtggt   3027

 cagcacctag acatgctcct cccccctccc tccccacttc ctgggggctc ccttgggata   3087

 acgtgcaccc tttcctaggg gataaagcac tgaaggcccc acgtccccca ccccttaaga   3147

 gtcccagcct gatctgtcca gcaacccact gttatctggg agctcctgtt ggtggaagtg   3207

 accaggtgag gccagggcca gcagcataag atgggcagtg cctatagcag aggggtgagt   3267

 gggatagtcc caccccatga gctggaagcc aggtgctggg agaaggtgat agctgagatc   3327

 acctgatatg cagcccccac acagtcctat aaccagcgca cctcacagcc ggcaagccca   3387

 gagtggaggc tgcagacctg ggcccagaac cgcaggggaa cctaagggta caacttccaa   3447

 gggctccgtt tctcc                                                    3462




      <210> 384
      <211> 879
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(699)

      <400> 384
 aaggatcctt aattaaatta atcccccccc cctcctcctg cacacctccc tcgctctccc     60

 acaccactgg caccaggccc cggacacccg ctctgctgca ggaga    atg gct act     114
                                                      Met Ala Thr
                                                        1

 cat cac acg ctg tgg atg gga ctg gcc ctg ctg ggg gtg ctg ggc gac      162
 His His Thr Leu Trp Met Gly Leu Ala Leu Leu Gly Val Leu Gly Asp
       5                  10                  15

 ctg cag gca gca ccg gag gcc cag gtc tcc gtg cag ccc aac ttc cag      210
 Leu Gln Ala Ala Pro Glu Ala Gln Val Ser Val Gln Pro Asn Phe Gln
  20                  25                  30                  35

 cag gac aag ttc ctg ggg cgc tgg ttc agc gcg ggc ctc gcc tcc aac      258
 Gln Asp Lys Phe Leu Gly Arg Trp Phe Ser Ala Gly Leu Ala Ser Asn
                  40                  45                  50

 tcg agc tgg ctc cgg gag aag aag gcg gcg ttg tcc atg tgc aag tct      306
 Ser Ser Trp Leu Arg Glu Lys Lys Ala Ala Leu Ser Met Cys Lys Ser
              55                  60                  65

 gtg gtg gcc cct gcc acg gat ggt ggc ctc aac ctg acc tcc acc ttc      354
 Val Val Ala Pro Ala Thr Asp Gly Gly Leu Asn Leu Thr Ser Thr Phe
          70                  75                  80

 ctc agg aaa aac cag tgt gag acc cga acc atg ctg ctg cag ccc gcg      402
 Leu Arg Lys Asn Gln Cys Glu Thr Arg Thr Met Leu Leu Gln Pro Ala
      85                  90                  95

 ggg tcc ctc ggc tcc tac agc tac cgg agt ccc cac tgg ggc agc acc      450
 Gly Ser Leu Gly Ser Tyr Ser Tyr Arg Ser Pro His Trp Gly Ser Thr
 100                 105                 110                 115

 tac tcc gtg tca gtg gtg gag acc gac tac gac cag tac gcg ctg ctg      498
 Tyr Ser Val Ser Val Val Glu Thr Asp Tyr Asp Gln Tyr Ala Leu Leu
                 120                 125                 130

 tac agc cag ggc agc aag ggc cct ggc gag gac ttc cgc atg gcc acc      546
 Tyr Ser Gln Gly Ser Lys Gly Pro Gly Glu Asp Phe Arg Met Ala Thr
             135                 140                 145

 ctc tac agc cga acc cag acc ccc agg gct gag tta aag gag aaa ttc      594
 Leu Tyr Ser Arg Thr Gln Thr Pro Arg Ala Glu Leu Lys Glu Lys Phe
         150                 155                 160

 acc gcc ttc tgc aag gcc cag ggc ttc aca gag gat acc att gtc ttc      642
 Thr Ala Phe Cys Lys Ala Gln Gly Phe Thr Glu Asp Thr Ile Val Phe
     165                 170                 175

 ctg ccc caa acc gcc cct ggc ttc ttt ctt ggc gat aag tgc atg acg      690
 Leu Pro Gln Thr Ala Pro Gly Phe Phe Leu Gly Asp Lys Cys Met Thr
 180                 185                 190                 195

 gaa caa tag gactccc cagggctgaa gctgggatcc cggccagcca ggtgaccccc      746
 Glu Gln 


 acgctctgga tgtctctgct ctgttccttc cccgagcccc tgccccggct ccccgccaaa    806

 gcacccctgc ccactcgggc ttcatcctgc acaataaact ccggaagcaa gtcagtaaaa    866

 aaaaaaaaaa aaa                                                       879




      <210> 385
      <211> 1287
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (222)..(1043)

      <400> 385
 ccggccgggt tccgctcctg ctggagcccg gtgcgtggaa ttccacgcga gtgccgggga     60

 gttcctgggg agccgggctt ctcttttggc ccccagcgtg ttgaccgagc ccgcttcaca    120

 caacccttcc tagggtgtgg agagcgggcc ccgccctgaa agggcaccgt gggctggggg    180

 gcctgttttg gagcaggcac cggtggccga gctccgtgac c    atg aag gtc aag     233
                                                  Met Lys Val Lys
                                                    1

 gtc atc ccc gtg ctc gag gac aac tac atg tac ctg gtc atc gag gag      281
 Val Ile Pro Val Leu Glu Asp Asn Tyr Met Tyr Leu Val Ile Glu Glu
   5                  10                  15                  20

 ctc acg cgc gag gcg gtg gcc gtg gac gtg gct gtg ccc aag agg ctg      329
 Leu Thr Arg Glu Ala Val Ala Val Asp Val Ala Val Pro Lys Arg Leu
                  25                  30                  35

 ctg gag atc gtg ggc cgg gag ggg gtg tct ctg acc gct gtg ctg acc      377
 Leu Glu Ile Val Gly Arg Glu Gly Val Ser Leu Thr Ala Val Leu Thr
              40                  45                  50

 acc cac cat cac tgg gac cac gcg cgg gga aac ccg gag ctg gcg cgg      425
 Thr His His His Trp Asp His Ala Arg Gly Asn Pro Glu Leu Ala Arg
          55                  60                  65

 ctt cgt ccc ggg ctg gcg gtg ctg ggc gcg gac gag cgc atc ttc tcg      473
 Leu Arg Pro Gly Leu Ala Val Leu Gly Ala Asp Glu Arg Ile Phe Ser
      70                  75                  80

 ctg acg cgc agg ctg gcg cac ggc gag gag ctg cgg ttc ggg gcc atc      521
 Leu Thr Arg Arg Leu Ala His Gly Glu Glu Leu Arg Phe Gly Ala Ile
  85                  90                  95                 100

 cac gtg cgt tgc ctc ctg acg ccc ggc cac acc gcc ggc cac atg agc      569
 His Val Arg Cys Leu Leu Thr Pro Gly His Thr Ala Gly His Met Ser
                 105                 110                 115

 tac ttc ctg tgg gag gac gat tgc ccg gac cca ccc gcc ctg ttc tcg      617
 Tyr Phe Leu Trp Glu Asp Asp Cys Pro Asp Pro Pro Ala Leu Phe Ser
             120                 125                 130

 ggc gac gcg ctg tcg gtg gcc ggc tgc ggc tcg tgc ctg gag ggc agc      665
 Gly Asp Ala Leu Ser Val Ala Gly Cys Gly Ser Cys Leu Glu Gly Ser
         135                 140                 145

 gcc cag cag atg tac cag agc ctg gcc gag ctg ggt acc ctg ccc ccc      713
 Ala Gln Gln Met Tyr Gln Ser Leu Ala Glu Leu Gly Thr Leu Pro Pro
     150                 155                 160

 gag acg aag gtg ttc tgc ggc cac gag cac acg ctt agc aac ctg gag      761
 Glu Thr Lys Val Phe Cys Gly His Glu His Thr Leu Ser Asn Leu Glu
 165                 170                 175                 180

 ttt gcc cag aaa gtg gag ccc tgc aac gac cac aag agg gat gag gat      809
 Phe Ala Gln Lys Val Glu Pro Cys Asn Asp His Lys Arg Asp Glu Asp
                 185                 190                 195

 gac gtg ccc act gtg ccg tcg act ctg ggc gag gag cgc ctc tac aac      857
 Asp Val Pro Thr Val Pro Ser Thr Leu Gly Glu Glu Arg Leu Tyr Asn
             200                 205                 210

 ccc ttc ctg cgg gtg gca gag gag ccg gtg cgc aag ttc acg ggc aag      905
 Pro Phe Leu Arg Val Ala Glu Glu Pro Val Arg Lys Phe Thr Gly Lys
         215                 220                 225

 gcg gtc ccc gcc gac gtc ctg gag gcg cta tgc aag gag cgg gcg cgc      953
 Ala Val Pro Ala Asp Val Leu Glu Ala Leu Cys Lys Glu Arg Ala Arg
     230                 235                 240

 ttc gaa cag gcg ggc gag ccg cgg cag cca cag gcg cgg gcc ctc ctt     1001
 Phe Glu Gln Ala Gly Glu Pro Arg Gln Pro Gln Ala Arg Ala Leu Leu
 245                 250                 255                 260

 gcg ctg cag tgg ggg ctc ctg agt gca gcc cca cac gac tga gccaccc     1050
 Ala Leu Gln Trp Gly Leu Leu Ser Ala Ala Pro His Asp 
                 265                 270

 agaccctcac agggctgggg cctgcgtccc tcctcgtgac ctcggccagc tggacccaca   1110

 tgagggccac ctctggaacc ttcttcgagg ccctggccag ccatctgccc agcctcggag   1170

 ggagcccaac ctggtgcttc ccgggtggac acacaggacc actcagtggg gcctgtgtgg   1230

 gcgccgagac ctgggtgtct gggaagtggg gcacacggtg cctccgaact atgaata      1287




      <210> 386
      <211> 1646
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(1200)

      <400> 386
 cccacgcgtc cggttactta ttaaacacaa gagatattat gtccggggga aaactgttgt     60

 aaactttgcc tgtaggagga ctgatctctt aatgaaatac agaaaaacca tctcagaaaa    120

 aggaaa   atg ggc aat cgt cat agc cag tcg tac acc ctc tca gaa ggc     168
          Met Gly Asn Arg His Ser Gln Ser Tyr Thr Leu Ser Glu Gly
            1               5                  10

 agt caa cag ttg cct aaa ggg gac tcc caa ccc tcg aca gtc gtg cag      216
 Ser Gln Gln Leu Pro Lys Gly Asp Ser Gln Pro Ser Thr Val Val Gln
  15                  20                  25                  30

 cct ctc agc cac cca tca cgg aat gga gag cca gag gcc cca cag cct      264
 Pro Leu Ser His Pro Ser Arg Asn Gly Glu Pro Glu Ala Pro Gln Pro
                  35                  40                  45

 gct aaa gcg agc agt cct cag ggt ttt gat gtg gat cga gat gcc aaa      312
 Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val Asp Arg Asp Ala Lys
              50                  55                  60

 aag ctg aac aaa gcc tgc aaa gga atg ggg acc aat gaa gca gcc atc      360
 Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr Asn Glu Ala Ala Ile
          65                  70                  75

 att gaa atc tta tcg ggc agg aca tca gat gag agg caa caa atc aag      408
 Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu Arg Gln Gln Ile Lys
      80                  85                  90

 caa aag tac aag gca acg tac ggc aag gag ctg gag gaa gta ctc aag      456
 Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu Glu Glu Val Leu Lys
  95                 100                 105                 110

 agt gag ctg agt gga aac ttc gag aag aca gcg ttg gcc ctt ctg gac      504
 Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala Leu Ala Leu Leu Asp
                 115                 120                 125

 cat ccc agc gag tac gcc gcc cgg cag ctg cag aag gct atg aag ggt      552
 His Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln Lys Ala Met Lys Gly
             130                 135                 140

 ctg ggc aca gat gag tcc gtc ctc att gag gtc ctg tgc acg agg acc      600
 Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val Leu Cys Thr Arg Thr
         145                 150                 155

 aat aag gaa atc atc gcc att aaa gag gcc tac caa agg cta ttt gat      648
 Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr Gln Arg Leu Phe Asp
     160                 165                 170

 agg agc ctc gaa tca gat gtc aaa ggt gat aca agt gga aac cta aaa      696
 Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr Ser Gly Asn Leu Lys
 175                 180                 185                 190

 aaa atc ctg gtg tct ctg ctg cag gct aat cgc aat gaa gga gat gac      744
 Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg Asn Glu Gly Asp Asp
                 195                 200                 205

 gtg gac aaa gat cta gct ggt cag gat gcc aaa gat ctg tat gat gca      792
 Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys Asp Leu Tyr Asp Ala
             210                 215                 220

 ggg gaa ggc cgc tgg ggc act gat gag ctt gcg ttc aat gaa gtc ctg      840
 Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala Phe Asn Glu Val Leu
         225                 230                 235

 gcc aag agg agc tac aag cag tta cga gcc acc ttt caa gcc tat caa      888
 Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr Phe Gln Ala Tyr Gln
     240                 245                 250

 att ctc att ggc aaa gac ata gaa gaa gcc att gaa gaa gaa aca tca      936
 Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile Glu Glu Glu Thr Ser
 255                 260                 265                 270

 ggc gac ttg cag aag gcc tat tta act ctc gtg aga tgt gcc cag gat      984
 Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val Arg Cys Ala Gln Asp
                 275                 280                 285

 tgt gag gac tat ttt gct gaa cgt ctg tac aag tcg atg aag ggt gcg     1032
 Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys Ser Met Lys Gly Ala
             290                 295                 300

 ggg acc gat gag gag acg ttg att cgc ata gtc gtg acc agg gcc gag     1080
 Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val Val Thr Arg Ala Glu
         305                 310                 315

 gtg gac ctt cag ggg atc aaa gca aag ttc caa gag aag tat cag aag     1128
 Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln Glu Lys Tyr Gln Lys
     320                 325                 330

 tct ctc tct gac atg gtt cgc tca gat acc tcc ggg gac ttc cgg aaa     1176
 Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser Gly Asp Phe Arg Lys
 335                 340                 345                 350

 ctg cta gta gcc ctc ttg cac tga gccaagccag ggcaatagga acacagggtg    1230
 Leu Leu Val Ala Leu Leu His 
                 355

 gaaccacctt tgtcaagagc acattccaaa tcaaacttgc aaatgagact cccgcacgaa   1290

 aacccttaag agtcccggat tactttcttg gcagcttaag tggcgcagcc aggccaagct   1350

 gtgtaagtta agggcagtaa cgttaagatg cgtgggcagg gcaccttgaa ctctggctta   1410

 gcaagcatct aggctgcctc ttcactttct tttagcatgg taactggatg ttttctaaac   1470

 actaatgaaa tcagcagttg atgaaaaaac tatgcatttg taatggcaca tttagaagga   1530

 tatgcatcac acaagtaagg tacaggaaag acaaaattaa acaatttatt aattttcctt   1590

 ctgtgtgttc aatttgaaag cctcattgtt aattaaagtt gtggattatg cctcta       1646




      <210> 387
      <211> 2597
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (529)..(2331)

      <400> 387
 aacatccccg ggtcgacgat ttcgtgggga gcttctttct tgctcaccct ggcgatggct     60

 agtatggccg cagagtgaga caaggctccc aattgcatcc ttggaggcaa agttaaagat    120

 tttatgatta agtacttaac atttcctgtt ggaagtttgg tggcctcaga tttctcctct    180

 gagcaggaca tacaacagag ggttggacac agatggccag agttgaagct aggccaggaa    240

 acatcgctgt gtctttggaa acaaaagtca ccttccttcc tccaggagca agggcgggtg    300

 agaggaagag ggcttataga gagccttttc aagcccctag cttggttatg ggttattttg    360

 tttttgtcat tttagggtga ggcaactcca aggtcctact ctctttctgt gcctgttacc    420

 caccccgtcc tcctagggtg cccttgagcc gcaaaactgc tgtccacgtg gaccgggggt    480

 gacatcgcac gtccatctgc caggacccct gcgtccaaat tccgagac atg gcg acc     537
                                                      Met Ala Thr
                                                        1

 aac ggc agc aag gtg gcc gac ggg cag atc tcc acc gag gtc agc gag      585
 Asn Gly Ser Lys Val Ala Asp Gly Gln Ile Ser Thr Glu Val Ser Glu
       5                  10                  15

 gcc cct gtg gcc aat gac aag ccc aaa acc ttg gtg gtc aag gtg cag      633
 Ala Pro Val Ala Asn Asp Lys Pro Lys Thr Leu Val Val Lys Val Gln
  20                  25                  30                  35

 aag aag gcg gca gac ctc ccc gac cgg gac acg tgg aag ggc cgc ttc      681
 Lys Lys Ala Ala Asp Leu Pro Asp Arg Asp Thr Trp Lys Gly Arg Phe
                  40                  45                  50

 gac ttc ctc atg tcc tgt gtg ggc tat gcc atc ggc ctg ggc aac gtc      729
 Asp Phe Leu Met Ser Cys Val Gly Tyr Ala Ile Gly Leu Gly Asn Val
              55                  60                  65

 tgg agg ttc ccc tat ctc tgc ggg aaa aat ggt ggg gga gcc ttc ctg      777
 Trp Arg Phe Pro Tyr Leu Cys Gly Lys Asn Gly Gly Gly Ala Phe Leu
          70                  75                  80

 atc ccc tat ttc ctg aca ctc atc ttt gcg ggg gtc cca ctc ttc ctg      825
 Ile Pro Tyr Phe Leu Thr Leu Ile Phe Ala Gly Val Pro Leu Phe Leu
      85                  90                  95

 ctg gag tgc tcc ctg ggc cag tac acc tcc atc ggg ggg cta ggg gta      873
 Leu Glu Cys Ser Leu Gly Gln Tyr Thr Ser Ile Gly Gly Leu Gly Val
 100                 105                 110                 115

 tgg aag ctg gct cct atg ttc aag ggc gtg ggc ctt gcg gct gct gtg      921
 Trp Lys Leu Ala Pro Met Phe Lys Gly Val Gly Leu Ala Ala Ala Val
                 120                 125                 130

 cta tca ttc tgg ctg aac atc tac tac atc gtc atc atc tcc tgg gcc      969
 Leu Ser Phe Trp Leu Asn Ile Tyr Tyr Ile Val Ile Ile Ser Trp Ala
             135                 140                 145

 att tac tac ctg tac aac tcc ttc acc acg aca ctg ccg tgg aaa cag     1017
 Ile Tyr Tyr Leu Tyr Asn Ser Phe Thr Thr Thr Leu Pro Trp Lys Gln
         150                 155                 160

 tgc gac aac ccc tgg aac aca gac cgc tgc ttc tcc aac tac agc atg     1065
 Cys Asp Asn Pro Trp Asn Thr Asp Arg Cys Phe Ser Asn Tyr Ser Met
     165                 170                 175

 gtc aac act acc aac atg acc agc gct gtg gtg gag ttc tgg gag cgc     1113
 Val Asn Thr Thr Asn Met Thr Ser Ala Val Val Glu Phe Trp Glu Arg
 180                 185                 190                 195

 aac atg cat cag atg acg gac ggg ctg gat aag cca ggt cag atc cgc     1161
 Asn Met His Gln Met Thr Asp Gly Leu Asp Lys Pro Gly Gln Ile Arg
                 200                 205                 210

 tgg cca ctg gcc atc acg ctg gcc atc gcc tgg atc ctt gtg tat ttc     1209
 Trp Pro Leu Ala Ile Thr Leu Ala Ile Ala Trp Ile Leu Val Tyr Phe
             215                 220                 225

 tgt atc tgg aag ggt gtt ggc tgg act gga aag gtg gtc tac ttt tca     1257
 Cys Ile Trp Lys Gly Val Gly Trp Thr Gly Lys Val Val Tyr Phe Ser
         230                 235                 240

 gcc aca tac ccc tac atc atg ctg atc atc ctg ttc ttc cgt gga gtg     1305
 Ala Thr Tyr Pro Tyr Ile Met Leu Ile Ile Leu Phe Phe Arg Gly Val
     245                 250                 255

 acg ctg ccc ggg gcc aag gag ggc atc ctc ttc tac atc aca ccc aac     1353
 Thr Leu Pro Gly Ala Lys Glu Gly Ile Leu Phe Tyr Ile Thr Pro Asn
 260                 265                 270                 275

 ttc cgc aag ctg tct gac tcc gag gtg tgg ctg gat gcg gca acc cag     1401
 Phe Arg Lys Leu Ser Asp Ser Glu Val Trp Leu Asp Ala Ala Thr Gln
                 280                 285                 290

 atc ttc ttc tca tac ggg ctg ggc ctg ggg tcc ctg atc gct ctt cgg     1449
 Ile Phe Phe Ser Tyr Gly Leu Gly Leu Gly Ser Leu Ile Ala Leu Arg
             295                 300                 305

 gga ggg aca aat ctt tcc aac aac aat gtc tat agg gac tcc atc atc     1497
 Gly Gly Thr Asn Leu Ser Asn Asn Asn Val Tyr Arg Asp Ser Ile Ile
         310                 315                 320

 gtc tgc tgc atc aat tcg cgc acc agc atg ttc gca gga ttc gtc atc     1545
 Val Cys Cys Ile Asn Ser Arg Thr Ser Met Phe Ala Gly Phe Val Ile
     325                 330                 335

 ttc tcc atc gtg ggc ttc atg gcc cat gtc acc aag agg tcc att gct     1593
 Phe Ser Ile Val Gly Phe Met Ala His Val Thr Lys Arg Ser Ile Ala
 340                 345                 350                 355

 gat gtg gcg gcc tca ggc ccc ggg ctg gcg ttc ctg gca tac cca gag     1641
 Asp Val Ala Ala Ser Gly Pro Gly Leu Ala Phe Leu Ala Tyr Pro Glu
                 360                 365                 370

 gcg gtg acc cag ctg cct atc tcc cca ctc tgg gcc atc ctc ttc ttc     1689
 Ala Val Thr Gln Leu Pro Ile Ser Pro Leu Trp Ala Ile Leu Phe Phe
             375                 380                 385

 tcc atg ctg ttg atg ctg ggc att gac agc cag ttc tgc act gtg gag     1737
 Ser Met Leu Leu Met Leu Gly Ile Asp Ser Gln Phe Cys Thr Val Glu
         390                 395                 400

 ggc ttc atc aca gcc ctg gtg gat gag tac ccc agg ctc ctc cgc aac     1785
 Gly Phe Ile Thr Ala Leu Val Asp Glu Tyr Pro Arg Leu Leu Arg Asn
     405                 410                 415

 cgc aga gag ctc ttc att gct gct gtc tgc atc atc tcc tac ctg atc     1833
 Arg Arg Glu Leu Phe Ile Ala Ala Val Cys Ile Ile Ser Tyr Leu Ile
 420                 425                 430                 435

 ggt ctc tct aac atc act cag ggg ggt att tat gtc ttc aaa ctc ttt     1881
 Gly Leu Ser Asn Ile Thr Gln Gly Gly Ile Tyr Val Phe Lys Leu Phe
                 440                 445                 450

 gac tac tac tct gcc agt ggc atg agc ctg ctg ttc ctc gtg ttc ttt     1929
 Asp Tyr Tyr Ser Ala Ser Gly Met Ser Leu Leu Phe Leu Val Phe Phe
             455                 460                 465

 gaa tgt gtc tct att tcc tgg ttt tac ggt gtc aac cga ttc tat gac     1977
 Glu Cys Val Ser Ile Ser Trp Phe Tyr Gly Val Asn Arg Phe Tyr Asp
         470                 475                 480

 aat atc caa gag atg gtt gga tcc agg ccc tgc atc tgg tgg aaa ctc     2025
 Asn Ile Gln Glu Met Val Gly Ser Arg Pro Cys Ile Trp Trp Lys Leu
     485                 490                 495

 tgc tgg tct ttc ttc aca cca atc att gtg gcg ggc gtg ttc att ttc     2073
 Cys Trp Ser Phe Phe Thr Pro Ile Ile Val Ala Gly Val Phe Ile Phe
 500                 505                 510                 515

 agt gct gtg cag atg acg cca ctc acc atg gga aac tat gtt ttc ccc     2121
 Ser Ala Val Gln Met Thr Pro Leu Thr Met Gly Asn Tyr Val Phe Pro
                 520                 525                 530

 aag tgg ggc cag ggt gtg ggc tgg ctg atg gct ctg tct tcc atg gtc     2169
 Lys Trp Gly Gln Gly Val Gly Trp Leu Met Ala Leu Ser Ser Met Val
             535                 540                 545

 ctc atc ccc ggg tac atg gcc tac atg ttc ctc acc tta aag ggc tcc     2217
 Leu Ile Pro Gly Tyr Met Ala Tyr Met Phe Leu Thr Leu Lys Gly Ser
         550                 555                 560

 ctg aag cag cgc atc caa gtc atg gtc cag ccc agc gaa gac atc gtt     2265
 Leu Lys Gln Arg Ile Gln Val Met Val Gln Pro Ser Glu Asp Ile Val
     565                 570                 575

 cgc cca gag aat ggt cct gag cag ccc cag gcg ggc agc tcc acc agc     2313
 Arg Pro Glu Asn Gly Pro Glu Gln Pro Gln Ala Gly Ser Ser Thr Ser
 580                 585                 590                 595

 aag gag gcc tac atc tag ggtggg ggccactcac cgacccgaca ctctcacccc     2367
 Lys Glu Ala Tyr Ile 
                 600

 ccgacctggc tgagtgcgac caccacttga tgtctgagga taccttccat ctcaacctac   2427

 ctcgagtggc gagtccagac acctatcacc acgcagagag gggaggtggg aggacagtta   2487

 gacccctggg tgggccctgc cgtgggcaag gatacccggt ggcttctggc actggcgggc   2547

 tggtgacctt tttaatccag gccccatcag catcccactc ctggcgggat              2597




      <210> 388
      <211> 953
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (327)..(800)

      <400> 388
 gcggtaccgg ttcggaattc ccgggtcgac gatttcgtgg cgactgtccg tggtgctgag     60

 cgccggcgag agcgggcgcg gagcggctga tcggctccct cgaactgggg aggtccagtg    120

 gggtcgctta gggcccaaag cccccacccg gctccaaaag ctcccagggc ctccccaggc    180

 accggtgctc ggcccttcct tcggtcagaa agtcgccccc tgggggcagt tcgtcccaaa    240

 gggtttcctc gaaagaatct gagagggcgc agtccttgac cgagggaatc tctctgtgta    300

 gccttggaag ccgccagccc cagaag atg cct gcc ttc aat aga ttg ttt ccc     353
                              Met Pro Ala Phe Asn Arg Leu Phe Pro
                                1               5

 ctg gct tct ctc gtg ctt atc tac tgg gtc agt gtc tgc ttc cct gtg      401
 Leu Ala Ser Leu Val Leu Ile Tyr Trp Val Ser Val Cys Phe Pro Val
  10                  15                  20                  25

 tgt gtg gaa gtg ccc tcg gag acg gag gcc gtg cag ggc aac ccc atg      449
 Cys Val Glu Val Pro Ser Glu Thr Glu Ala Val Gln Gly Asn Pro Met
                  30                  35                  40

 aag ctg cgc tgc atc tcc tgc atg aag aga gag gag gtg gag gcc acc      497
 Lys Leu Arg Cys Ile Ser Cys Met Lys Arg Glu Glu Val Glu Ala Thr
              45                  50                  55

 acg gtg gtg gaa tgg ttc tac agg ccc gag ggc ggt aaa gat ttc ctt      545
 Thr Val Val Glu Trp Phe Tyr Arg Pro Glu Gly Gly Lys Asp Phe Leu
          60                  65                  70

 att tac gag tat cgg aat ggc cac cag gag gtg gag agc ccc ttt cag      593
 Ile Tyr Glu Tyr Arg Asn Gly His Gln Glu Val Glu Ser Pro Phe Gln
      75                  80                  85

 ggg cgc ctg cag tgg aat ggc agc aag gac ctg cag gac gtg tcc atc      641
 Gly Arg Leu Gln Trp Asn Gly Ser Lys Asp Leu Gln Asp Val Ser Ile
  90                  95                 100                 105

 act gtg ctc aac gtc act ctg aac gac tct ggc ctc tac acc tgc aat      689
 Thr Val Leu Asn Val Thr Leu Asn Asp Ser Gly Leu Tyr Thr Cys Asn
                 110                 115                 120

 gtg tcc cgg gag ttt gag ttt gag gcg cat cgg ccc ttt gtg aag acg      737
 Val Ser Arg Glu Phe Glu Phe Glu Ala His Arg Pro Phe Val Lys Thr
             125                 130                 135

 acg cgg ctg atc ccc cta aga gtc acc gag gag gct gga gag gac ttc      785
 Thr Arg Leu Ile Pro Leu Arg Val Thr Glu Glu Ala Gly Glu Asp Phe
         140                 145                 150

 acc tct gtg gtc taa cacttcatga tgtacatcct tctggtgttc ctcacccttg      840
 Thr Ser Val Val 
     155

 tgaaccaacg ccagcctgct ccagagcact ctagtgcttc caccagtgct cctgatagtc    900

 atctgggctt cccagccatc cctcaaggag gggccaatga agatgagact tga           953




      <210> 389
      <211> 2507
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (223)..(1962)

      <400> 389
 cgcgccggaa tctcccgggt cgacgatttc gtggctcccc gctcccattg tctcggcaga     60

 tgccgcctgg tccagctatc gtgctcggta ttcagttttc cggagcagcg ctctttctct    120

 ggcccgcgga gcggtcccgc ggccgagtac cggattcccg agtttgggag gctctgcttt    180

 cctccttagg acccactttg ccgtcctggg gtggctgcag tt   atg tcc gcg ctg     234
                                                  Met Ser Ala Leu
                                                    1

 cga cct ctc ctg ctt ctg ctg ctg cct ctg tgt ccc ggt cct ggt ccc      282
 Arg Pro Leu Leu Leu Leu Leu Leu Pro Leu Cys Pro Gly Pro Gly Pro
   5                  10                  15                  20

 gga ccc ggg agc gag gca aag gtc acc cgg agt tgt gca gag acc cgg      330
 Gly Pro Gly Ser Glu Ala Lys Val Thr Arg Ser Cys Ala Glu Thr Arg
                  25                  30                  35

 cag gtg ctg ggg gcc cgg gga tat agc tta aac cta atc cct ccc gcc      378
 Gln Val Leu Gly Ala Arg Gly Tyr Ser Leu Asn Leu Ile Pro Pro Ala
              40                  45                  50

 ctg atc tca ggt gag cac ctc cgg gtc tgt ccc cag gag tac acc tgc      426
 Leu Ile Ser Gly Glu His Leu Arg Val Cys Pro Gln Glu Tyr Thr Cys
          55                  60                  65

 tgt tcc agt gag aca gag cag agg ctg atc agg gag act gag gcc acc      474
 Cys Ser Ser Glu Thr Glu Gln Arg Leu Ile Arg Glu Thr Glu Ala Thr
      70                  75                  80

 ttc cga ggc ctg gtg gag gac agc ggc tcc ttt ctg gtt cac aca ctg      522
 Phe Arg Gly Leu Val Glu Asp Ser Gly Ser Phe Leu Val His Thr Leu
  85                  90                  95                 100

 gct gcc agg cac aga aaa ttt gat gag ttt ttt ctg gag atg ctc tca      570
 Ala Ala Arg His Arg Lys Phe Asp Glu Phe Phe Leu Glu Met Leu Ser
                 105                 110                 115

 gta gcc cag cac tct ctg acc cag ctc ttc tcc cac tcc tac ggc cgc      618
 Val Ala Gln His Ser Leu Thr Gln Leu Phe Ser His Ser Tyr Gly Arg
             120                 125                 130

 ctg tat gcc cag cac gcc ctc ata ttc aat ggc ctg ttc tct cgg ctg      666
 Leu Tyr Ala Gln His Ala Leu Ile Phe Asn Gly Leu Phe Ser Arg Leu
         135                 140                 145

 cga gac ttc tat ggg gaa tct ggt gag ggg ttg gat gac acc ctg gcg      714
 Arg Asp Phe Tyr Gly Glu Ser Gly Glu Gly Leu Asp Asp Thr Leu Ala
     150                 155                 160

 gat ttc tgg gca cag ctc ctg gag aga gtg ttc ccg ctg ctg cac cca      762
 Asp Phe Trp Ala Gln Leu Leu Glu Arg Val Phe Pro Leu Leu His Pro
 165                 170                 175                 180

 cag tac agc ttc ccc cct gac tac ctg ctc tgc ctc tca cgc ttg gcc      810
 Gln Tyr Ser Phe Pro Pro Asp Tyr Leu Leu Cys Leu Ser Arg Leu Ala
                 185                 190                 195

 tca tct acc gat ggc tct ctg cag ccc ttt ggg gac tca ccc cgc cgc      858
 Ser Ser Thr Asp Gly Ser Leu Gln Pro Phe Gly Asp Ser Pro Arg Arg
             200                 205                 210

 ctc cgc ctg cag ata acc cgg acc ctg gtg gct gcc cga gcc ttt gtg      906
 Leu Arg Leu Gln Ile Thr Arg Thr Leu Val Ala Ala Arg Ala Phe Val
         215                 220                 225

 cag ggc ctg gag act gga aga aat gtg gtc agc gaa gcg ctt aag gtg      954
 Gln Gly Leu Glu Thr Gly Arg Asn Val Val Ser Glu Ala Leu Lys Val
     230                 235                 240

 ccg gtg tct gaa ggc tgc agc cag gct ctg atg cgt ctc atc ggc tgt     1002
 Pro Val Ser Glu Gly Cys Ser Gln Ala Leu Met Arg Leu Ile Gly Cys
 245                 250                 255                 260

 ccc ctg tgc cgg ggg gtc ccc tca ctt atg ccc tgc cag ggc ttc tgc     1050
 Pro Leu Cys Arg Gly Val Pro Ser Leu Met Pro Cys Gln Gly Phe Cys
                 265                 270                 275

 ctc aac gtg gtt cgt ggc tgt ctc agc agc agg gga ctg gag cct gac     1098
 Leu Asn Val Val Arg Gly Cys Leu Ser Ser Arg Gly Leu Glu Pro Asp
             280                 285                 290

 tgg ggc aac tat ctg gat ggt ctc ctg atc ctg gct gat aag ctc cag     1146
 Trp Gly Asn Tyr Leu Asp Gly Leu Leu Ile Leu Ala Asp Lys Leu Gln
         295                 300                 305

 ggc ccc ttt tcc ttt gag ctg acg gcc gag tcc att ggg gtg aag atc     1194
 Gly Pro Phe Ser Phe Glu Leu Thr Ala Glu Ser Ile Gly Val Lys Ile
     310                 315                 320

 tcg gag ggt ttg atg tac ctg cag gaa aac agt gcg aag gtg tcc gcc     1242
 Ser Glu Gly Leu Met Tyr Leu Gln Glu Asn Ser Ala Lys Val Ser Ala
 325                 330                 335                 340

 cag gtg ttt cag gag tgc ggc ccc ccc gac ccg gtg cct gcc cgc aac     1290
 Gln Val Phe Gln Glu Cys Gly Pro Pro Asp Pro Val Pro Ala Arg Asn
                 345                 350                 355

 cgt cga gcc ccg ccg ccc cgg gaa gag gcg ggc cgg ctg tgg tcg atg     1338
 Arg Arg Ala Pro Pro Pro Arg Glu Glu Ala Gly Arg Leu Trp Ser Met
             360                 365                 370

 gtg acc gag gag gag cgg ccc acg acg gcc gca ggc acc aac ctg cac     1386
 Val Thr Glu Glu Glu Arg Pro Thr Thr Ala Ala Gly Thr Asn Leu His
         375                 380                 385

 cgg ctg gtg tgg gag ctc cgc gag cgt ctg gcc cgg atg cgg ggc ttc     1434
 Arg Leu Val Trp Glu Leu Arg Glu Arg Leu Ala Arg Met Arg Gly Phe
     390                 395                 400

 tgg gcc cgg ctg tcc ctg acg gtg tgc gga gac tct cgc atg gca gcg     1482
 Trp Ala Arg Leu Ser Leu Thr Val Cys Gly Asp Ser Arg Met Ala Ala
 405                 410                 415                 420

 gac gcc tcg ctg gag gcg gcg ccc tgc tgg acc gga gcc ggg cgg ggc     1530
 Asp Ala Ser Leu Glu Ala Ala Pro Cys Trp Thr Gly Ala Gly Arg Gly
                 425                 430                 435

 cgg tac ttg ccg cca gtg gtc ggg ggc tcc ccg gcc gag cag gtc aac     1578
 Arg Tyr Leu Pro Pro Val Val Gly Gly Ser Pro Ala Glu Gln Val Asn
             440                 445                 450

 aac ccc gag ctc aag gtg gac gcc tcg ggc ccc gat gtc ccg aca cgg     1626
 Asn Pro Glu Leu Lys Val Asp Ala Ser Gly Pro Asp Val Pro Thr Arg
         455                 460                 465

 cgg cgt cgg cta cag ctc cgg gcg gcc acg gcc aga atg aaa acg gcc     1674
 Arg Arg Arg Leu Gln Leu Arg Ala Ala Thr Ala Arg Met Lys Thr Ala
     470                 475                 480

 gca ctg gga cac gac ctg gac ggg cag gac gcg gat gag gat gcc agc     1722
 Ala Leu Gly His Asp Leu Asp Gly Gln Asp Ala Asp Glu Asp Ala Ser
 485                 490                 495                 500

 ggc tct gga ggg gga cag cag tat gca gat gac tgg atg gct ggg gct     1770
 Gly Ser Gly Gly Gly Gln Gln Tyr Ala Asp Asp Trp Met Ala Gly Ala
                 505                 510                 515

 gtg gct ccc cca gcc cgg cct cct cgg cct cca tac cct cct aga agg     1818
 Val Ala Pro Pro Ala Arg Pro Pro Arg Pro Pro Tyr Pro Pro Arg Arg
             520                 525                 530

 gat ggt tct ggg ggc aaa gga gga ggt ggc agt gcc cgc tac aac cag     1866
 Asp Gly Ser Gly Gly Lys Gly Gly Gly Gly Ser Ala Arg Tyr Asn Gln
         535                 540                 545

 ggc cgg agc agg agt ggg ggg gca tct att ggt ttt cac acc caa acc     1914
 Gly Arg Ser Arg Ser Gly Gly Ala Ser Ile Gly Phe His Thr Gln Thr
     550                 555                 560

 atc ctc att ctc tcc ctc tca gcc ctg gcc ctg ctt gga cct cga taa     1962
 Ile Leu Ile Leu Ser Leu Ser Ala Leu Ala Leu Leu Gly Pro Arg 
 565                 570                 575

 cgggggaggg gtgccctagc atcagaaggg ttcatggccc tttcccctcc tcccccctca   2022

 gctgggcctg gggaggagtc gaagggggct gcagagaggg tagagaaggg actttgcagg   2082

 tgaatggctg gggccccaaa tccaggagat tttcatcaga ggtgggtggg tgttcacaat   2142

 atttattttt tcatttggta atgggagggg ggcctggggg tatttattta ggagggagtg   2202

 tggtttcctt agaaggtata gtctctagcc ctctaaggct ggggctggtg atcagcccca   2262

 acagagaaaa tgaggagttt agagttgcag ctggggaagg ggtttgaagg aagttggaag   2322

 tggggagggg tgggggcatc tggtctcaga aatggaccag ctggatgcag ggcaggggac   2382

 tgagggtgct tgagtaggat gtgagacttc atgggcctgg gttctgttga gttttttcag   2442

 tatcaatttc ttaaaccaaa ttttaaaaaa aacaaggtgg gggggtgctc atctcgtacc   2502

 tctgc                                                               2507




      <210> 390
      <211> 2746
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(2657)

      <400> 390
 gcttgtgttt ttgtcggtac aggagggtcg ct  atg gcg gcg gag gat tcg gat      53
                                      Met Ala Ala Glu Asp Ser Asp
                                        1               5

 gtc gaa tcg ctg ccg cgt ggg ggg ttc cgc tgc tgc ctc tgc cac gtt      101
 Val Glu Ser Leu Pro Arg Gly Gly Phe Arg Cys Cys Leu Cys His Val
          10                  15                  20

 act aca gcc aac cga ccc agc ctt gat gcc cac ttg gga ggc aga aag      149
 Thr Thr Ala Asn Arg Pro Ser Leu Asp Ala His Leu Gly Gly Arg Lys
      25                  30                  35

 cac cgg cac ctg gta gaa cta cga gct gcg aga aag gcc cag gga ctt      197
 His Arg His Leu Val Glu Leu Arg Ala Ala Arg Lys Ala Gln Gly Leu
  40                  45                  50                  55

 cga agt gtg ttt gtc agt ggc ttt ccc agg gat ttg gat tct gct cag      245
 Arg Ser Val Phe Val Ser Gly Phe Pro Arg Asp Leu Asp Ser Ala Gln
                  60                  65                  70

 ctc tct gag tac ttc cta gca ttt gga cct gtg gcc agt gtt gtc atg      293
 Leu Ser Glu Tyr Phe Leu Ala Phe Gly Pro Val Ala Ser Val Val Met
              75                  80                  85

 gac aag gac aag gga gtg ttt gcc att gtg gag atg ggg gac gtg ggt      341
 Asp Lys Asp Lys Gly Val Phe Ala Ile Val Glu Met Gly Asp Val Gly
          90                  95                 100

 gct cga gag gct gtc ttg tca cag tcc cag cac agc ctg gga gga cat      389
 Ala Arg Glu Ala Val Leu Ser Gln Ser Gln His Ser Leu Gly Gly His
     105                 110                 115

 cgc ctg cgt gtc cgc cca cgg gag cag aag gag ttc cag agc ccg gcc      437
 Arg Leu Arg Val Arg Pro Arg Glu Gln Lys Glu Phe Gln Ser Pro Ala
 120                 125                 130                 135

 tcc aaa tcc ccc aaa gga gcg gcc ccc gac agt cac cag ctg gcc aaa      485
 Ser Lys Ser Pro Lys Gly Ala Ala Pro Asp Ser His Gln Leu Ala Lys
                 140                 145                 150

 gcg cta gct gag gct gca gac gtg ggg gca caa atg ata aag ctt gtg      533
 Ala Leu Ala Glu Ala Ala Asp Val Gly Ala Gln Met Ile Lys Leu Val
             155                 160                 165

 ggg ctg agg gag ttg tcc gag gcc gag cgg cag ctt cgc agc cta gtg      581
 Gly Leu Arg Glu Leu Ser Glu Ala Glu Arg Gln Leu Arg Ser Leu Val
         170                 175                 180

 gtg gcc ctg atg cag gag gtc ttc aca gag ttc ttc cct ggc tgt gtg      629
 Val Ala Leu Met Gln Glu Val Phe Thr Glu Phe Phe Pro Gly Cys Val
     185                 190                 195

 gtc cac cct ttt ggc tct tcc ata aat agc ttc gat gtc cat ggc tgt      677
 Val His Pro Phe Gly Ser Ser Ile Asn Ser Phe Asp Val His Gly Cys
 200                 205                 210                 215

 gat ctt gac ctc ttc ttg gat ctg ggt gac ttg gaa gag ccc cag cca      725
 Asp Leu Asp Leu Phe Leu Asp Leu Gly Asp Leu Glu Glu Pro Gln Pro
                 220                 225                 230

 gtc cca aag gct cca gaa tct cca tcg ctg gac tcg gcc ctg gct tcc      773
 Val Pro Lys Ala Pro Glu Ser Pro Ser Leu Asp Ser Ala Leu Ala Ser
             235                 240                 245

 cca ctg gac cct caa gcc ctg gcc tgc acc cca gct tcc cct cca gat      821
 Pro Leu Asp Pro Gln Ala Leu Ala Cys Thr Pro Ala Ser Pro Pro Asp
         250                 255                 260

 tca caa cct cct gct tct ccc cag gat tct gaa gcc ctg gac ttt gaa      869
 Ser Gln Pro Pro Ala Ser Pro Gln Asp Ser Glu Ala Leu Asp Phe Glu
     265                 270                 275

 acc cct tcc tcc tcc ctg gcg ccc caa act ccg gac tct gcc ttg gcc      917
 Thr Pro Ser Ser Ser Leu Ala Pro Gln Thr Pro Asp Ser Ala Leu Ala
 280                 285                 290                 295

 tcc gag acc ctt gct tct ccc cag tct ctg cct cca gct tca cca ctg      965
 Ser Glu Thr Leu Ala Ser Pro Gln Ser Leu Pro Pro Ala Ser Pro Leu
                 300                 305                 310

 cta gag gac agg gaa gag ggg gac ctg ggg aag gcc tcg gaa cta gca     1013
 Leu Glu Asp Arg Glu Glu Gly Asp Leu Gly Lys Ala Ser Glu Leu Ala
             315                 320                 325

 gag acc cca aag gag gag aaa gca gag ggg gca gca atg ctg gag ctg     1061
 Glu Thr Pro Lys Glu Glu Lys Ala Glu Gly Ala Ala Met Leu Glu Leu
         330                 335                 340

 gtg gga tcc att ctc cgg ggc tgt gtc cct ggg gtg tat cga gtc caa     1109
 Val Gly Ser Ile Leu Arg Gly Cys Val Pro Gly Val Tyr Arg Val Gln
     345                 350                 355

 act gtg ccc tct gcc cgg cgc cct gtg gtc aag ttc tgt cat cgg cct     1157
 Thr Val Pro Ser Ala Arg Arg Pro Val Val Lys Phe Cys His Arg Pro
 360                 365                 370                 375

 tca ggt ctc cac ggt gat gtc tcc ctc agt aac cgg ctg gcc ctg cat     1205
 Ser Gly Leu His Gly Asp Val Ser Leu Ser Asn Arg Leu Ala Leu His
                 380                 385                 390

 aac tcc cgt ttc ctg agt ctc tgc tct gag ctg gat ggt cga gtc cgg     1253
 Asn Ser Arg Phe Leu Ser Leu Cys Ser Glu Leu Asp Gly Arg Val Arg
             395                 400                 405

 ccc ctc gtg tac acc ctc cgc tgc tgg gct cag ggt cgg ggg ctg tca     1301
 Pro Leu Val Tyr Thr Leu Arg Cys Trp Ala Gln Gly Arg Gly Leu Ser
         410                 415                 420

 ggg agt ggc ccc ctt ctc agt aac tac gcc ctg acc ttg ctg gtg atc     1349
 Gly Ser Gly Pro Leu Leu Ser Asn Tyr Ala Leu Thr Leu Leu Val Ile
     425                 430                 435

 tat ttt ctt cag acc agg gac cct cct gtg ttg ccc act gtg tcc cag     1397
 Tyr Phe Leu Gln Thr Arg Asp Pro Pro Val Leu Pro Thr Val Ser Gln
 440                 445                 450                 455

 ctc acc cag aaa gca gga gag ggg gaa cag gtg gaa gtc gat ggc tgg     1445
 Leu Thr Gln Lys Ala Gly Glu Gly Glu Gln Val Glu Val Asp Gly Trp
                 460                 465                 470

 gac tgc agt ttc ccc agg gat gcc tca aga ctg gag ccc agc ata aat     1493
 Asp Cys Ser Phe Pro Arg Asp Ala Ser Arg Leu Glu Pro Ser Ile Asn
             475                 480                 485

 gtg gag ccc ctc agt tcc ctg cta gcc cag ttc ttc tcc tgt gta tct     1541
 Val Glu Pro Leu Ser Ser Leu Leu Ala Gln Phe Phe Ser Cys Val Ser
         490                 495                 500

 tgt tgg gat ctt cgt ggc tcc ctg ctg tcc ctg cgg gag ggt cag gca     1589
 Cys Trp Asp Leu Arg Gly Ser Leu Leu Ser Leu Arg Glu Gly Gln Ala
     505                 510                 515

 ctg cct gtg gca ggg ggc ctg cct tct aat ctc tgg gag ggt ctg cgc     1637
 Leu Pro Val Ala Gly Gly Leu Pro Ser Asn Leu Trp Glu Gly Leu Arg
 520                 525                 530                 535

 ctt ggc ccc ctg aat ctc cag gac cct ttt gac ctg agt cac aat gtc     1685
 Leu Gly Pro Leu Asn Leu Gln Asp Pro Phe Asp Leu Ser His Asn Val
                 540                 545                 550

 gca gcc aat gtg acc agc cgg gtg gct ggg cgc cta cag aac tgc tgc     1733
 Ala Ala Asn Val Thr Ser Arg Val Ala Gly Arg Leu Gln Asn Cys Cys
             555                 560                 565

 cga gca gca gcc aat tac tgc cga agc ctc cag tac cag cgc cgt tcc     1781
 Arg Ala Ala Ala Asn Tyr Cys Arg Ser Leu Gln Tyr Gln Arg Arg Ser
         570                 575                 580

 tcc cgg ggt cgg gac tgg ggg ctg ctc cct ctt ctg cag ccc agc tcc     1829
 Ser Arg Gly Arg Asp Trp Gly Leu Leu Pro Leu Leu Gln Pro Ser Ser
     585                 590                 595

 ccc agc tcc ctg ctc tct gct acg ccg atc cct tta ccc ctt gca ccc     1877
 Pro Ser Ser Leu Leu Ser Ala Thr Pro Ile Pro Leu Pro Leu Ala Pro
 600                 605                 610                 615

 ttc acc cag ctc act gct gcc ctg gtg cag gta ttc agg gaa gca ctg     1925
 Phe Thr Gln Leu Thr Ala Ala Leu Val Gln Val Phe Arg Glu Ala Leu
                 620                 625                 630

 ggg tgc cat ata gaa cag gca acc aag aga acg cgg tca gaa gga ggt     1973
 Gly Cys His Ile Glu Gln Ala Thr Lys Arg Thr Arg Ser Glu Gly Gly
             635                 640                 645

 gga act ggg gag tcc tct cag gga ggg aca agc aaa aga ctc aaa gta     2021
 Gly Thr Gly Glu Ser Ser Gln Gly Gly Thr Ser Lys Arg Leu Lys Val
         650                 655                 660

 gat gga cag aaa aac tgc tgt gag gag ggg aaa gag gag cag cag gga     2069
 Asp Gly Gln Lys Asn Cys Cys Glu Glu Gly Lys Glu Glu Gln Gln Gly
     665                 670                 675

 tgt gca ggg gac ggt ggg gaa gac agg gta gaa gag atg gtt ata gag     2117
 Cys Ala Gly Asp Gly Gly Glu Asp Arg Val Glu Glu Met Val Ile Glu
 680                 685                 690                 695

 gtt gga gag atg gtg cag gac tgg gcc atg cag agc cct ggg cag cca     2165
 Val Gly Glu Met Val Gln Asp Trp Ala Met Gln Ser Pro Gly Gln Pro
                 700                 705                 710

 ggg gac ctg ccc ctg acc act gga aag cat gga gcc cct gga gaa gag     2213
 Gly Asp Leu Pro Leu Thr Thr Gly Lys His Gly Ala Pro Gly Glu Glu
             715                 720                 725

 ggg cag ccc agc cac gca gcc ctg gca gag cgg ggg ccc aag gga cat     2261
 Gly Gln Pro Ser His Ala Ala Leu Ala Glu Arg Gly Pro Lys Gly His
         730                 735                 740

 gag gca gcc caa gaa tgg tct cag ggt gag gca ggg aag ggg gca tcc     2309
 Glu Ala Ala Gln Glu Trp Ser Gln Gly Glu Ala Gly Lys Gly Ala Ser
     745                 750                 755

 ctg ccc tcc tca gcg agc tgg cgc tgt gcc ttg tgg cac cga gtg tgg     2357
 Leu Pro Ser Ser Ala Ser Trp Arg Cys Ala Leu Trp His Arg Val Trp
 760                 765                 770                 775

 caa ggg cgg cgg cga gcc cgt aga cgc ttg cag cag caa acc aag gag     2405
 Gln Gly Arg Arg Arg Ala Arg Arg Arg Leu Gln Gln Gln Thr Lys Glu
                 780                 785                 790

 gga gct gga ggt ggc gct ggc aca aga gca ggg tgg ctg gcg act gag     2453
 Gly Ala Gly Gly Gly Ala Gly Thr Arg Ala Gly Trp Leu Ala Thr Glu
             795                 800                 805

 gct cag gtc acc cag gag ctg aaa gga ctg agt ggt ggc gaa gag agg     2501
 Ala Gln Val Thr Gln Glu Leu Lys Gly Leu Ser Gly Gly Glu Glu Arg
         810                 815                 820

 cca gaa act gag ccc ctg ctg agc ttt gtg gcg tct gtc tcc ccg gct     2549
 Pro Glu Thr Glu Pro Leu Leu Ser Phe Val Ala Ser Val Ser Pro Ala
     825                 830                 835

 gac cga atg ctc act gtg acc ccg ctc cag gat ccc caa ggc ctg ttc     2597
 Asp Arg Met Leu Thr Val Thr Pro Leu Gln Asp Pro Gln Gly Leu Phe
 840                 845                 850                 855

 cct gat ctc cat cat ttc tta cag gtt ttc ctc cct caa gca att cga     2645
 Pro Asp Leu His His Phe Leu Gln Val Phe Leu Pro Gln Ala Ile Arg
                 860                 865                 870

 cat ctc aag tga aga catggcccct gaagggcaat aaagctgcta gtttattaat     2700
 His Leu Lys 


 acagtctccc gtttcctttc aattccatct ggtcataatc cccctt                  2746




      <210> 391
      <211> 2291
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (238)..(1827)

      <400> 391
 gggaaaactg gcaagaactc gacagcccca gtcacttaaa ccatcgtaga caaagcacat     60

 gtgaaggtgt gattaaggag cactgtccca ttggtgcctg gggacagatg atttgcctgg    120

 tgggcctctt atatcccccg atgtcattta tatcacacca gctaatgatg ggatatggca    180

 gttcattctg ccacccatct gcattaagac acaaggtgct gaccgcagag acctgcc       237                                                                 
 atg aaa cca cac ttg aag caa tgg aga caa cga atg ctt ttc gga ata      285
 Met Lys Pro His Leu Lys Gln Trp Arg Gln Arg Met Leu Phe Gly Ile
   1               5                  10                  15

 ttc gct tgg ggg ctc ctc ttt ttg ctg att ttc atc tac ttc acc gac      333
 Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe Ile Tyr Phe Thr Asp
              20                  25                  30

 agc aac ccc gct gag cct gta ccc agc tcc ctc tcc ttc ctg gag acc      381
 Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu Ser Phe Leu Glu Thr
          35                  40                  45

 agg agg ctc ctg ccg gtg cag ggg aag cag cgg gcc atc atg ggc gcc      429
 Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg Ala Ile Met Gly Ala
      50                  55                  60

 gca cat gag ccc tcc ccg cct ggg ggc ctg gac gca cgc cag gcg ctg      477
 Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp Ala Arg Gln Ala Leu
  65                  70                  75                  80

 ccc cgc gcc cac cca gcc ggt tcc ttt cat gcg ggg cct gga gac ctg      525
 Pro Arg Ala His Pro Ala Gly Ser Phe His Ala Gly Pro Gly Asp Leu
                  85                  90                  95

 cag aaa tgg gcc cag tcc caa gat ggg ttt gaa cat aaa gag ttt ttt      573
 Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu His Lys Glu Phe Phe
             100                 105                 110

 tca tcc cag gtg ggg aga aaa tct caa agt gct ttc tac ccg gag gat      621
 Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala Phe Tyr Pro Glu Asp
         115                 120                 125

 gac gac tac ttt ttt gct gct ggt cag cca ggg tgg cac agc cac act      669
 Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly Trp His Ser His Thr
     130                 135                 140

 cag ggg aca ttg gga ttc cct tcc ccc ggg gag cca ggc cca cgg gag      717
 Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu Pro Gly Pro Arg Glu
 145                 150                 155                 160

 ggg gct ttt ccg gct gca cag gtc cag agg agg cgg gtg aag aag agg      765
 Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg Arg Val Lys Lys Arg
                 165                 170                 175

 cac cgg agg cag aga agg agc cac gtg ttg gag gag ggc gac gac ggc      813
 His Arg Arg Gln Arg Arg Ser His Val Leu Glu Glu Gly Asp Asp Gly
             180                 185                 190

 gac agg ctg tac tcc tcc atg tcc agg gcc ttc ctg tac cgg ctc tgg      861
 Asp Arg Leu Tyr Ser Ser Met Ser Arg Ala Phe Leu Tyr Arg Leu Trp
         195                 200                 205

 aag ggg aac gtc tct tcc aaa atg ctg aac ccg cgc ctg cag aag gcg      909
 Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro Arg Leu Gln Lys Ala
     210                 215                 220

 atg aag gat tac ctg acc gcc aac aag cac ggg gtg cgc ttc cgc ggg      957
 Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly Val Arg Phe Arg Gly
 225                 230                 235                 240

 aag cgg gag gcc ggg ctg agc agg gca cag ctg ctg tgc cag ctg cgg     1005
 Lys Arg Glu Ala Gly Leu Ser Arg Ala Gln Leu Leu Cys Gln Leu Arg
                 245                 250                 255

 agc cgc gcg cgc gtg cgg acg ctg gac ggc acc gag gcg ccc ttt tct     1053
 Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr Glu Ala Pro Phe Ser
             260                 265                 270

 gcg ctg ggc tgg cgg cgc ctg gtg ccc gcc gtg ccc ctg agc cag ctg     1101
 Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val Pro Leu Ser Gln Leu
         275                 280                 285

 cac ccc cgc ggc ctg cgc agc tgc gct gtc gtc atg tct gca ggc gca     1149
 His Pro Arg Gly Leu Arg Ser Cys Ala Val Val Met Ser Ala Gly Ala
     290                 295                 300

 atc ctc aac tct tcc ttg ggc gag gaa ata gat tct cat gat gcg gtt     1197
 Ile Leu Asn Ser Ser Leu Gly Glu Glu Ile Asp Ser His Asp Ala Val
 305                 310                 315                 320

 ttg aga ttt aac tct gct cct aca cgt ggt tat gag aaa gat gtt ggg     1245
 Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val Gly
                 325                 330                 335

 aat aaa acc acc ata cgc atc att aat tcg cag att ctg acc aac ccc     1293
 Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn Pro
             340                 345                 350

 agc cat cac ttc att gac agt tca ctg tat aaa gac gtc att ttg gtg     1341
 Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu Val
         355                 360                 365

 gcc tgg gac cct gcc cca tat tcc gca aat ctt aac ctg tgg tac aaa     1389
 Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr Lys
     370                 375                 380

 aaa ccg gat tac aac ctg ttc act cca tat att cag cat cgt cag aga     1437
 Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln Arg
 385                 390                 395                 400

 aac cca aat cag cca ttt tac att ctt cat cct aaa ttt ata tgg cag     1485
 Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp Gln
                 405                 410                 415

 ctc tgg gat att atc cag gag aac act aaa gag aag att caa cca aac     1533
 Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro Asn
             420                 425                 430

 cca cca tct tct ggt ttc att gga atc ctc atc atg atg tcc atg tgc     1581
 Pro Pro Ser Ser Gly Phe Ile Gly Ile Leu Ile Met Met Ser Met Cys
         435                 440                 445

 aga gag gtg cac gtg tat gaa tat atc cca tcc gtg cgg cag acg gag     1629
 Arg Glu Val His Val Tyr Glu Tyr Ile Pro Ser Val Arg Gln Thr Glu
     450                 455                 460

 ctg tgc cac tac cac gag ctg tac tac gac gca gcc tgc acc ctc ggg     1677
 Leu Cys His Tyr His Glu Leu Tyr Tyr Asp Ala Ala Cys Thr Leu Gly
 465                 470                 475                 480

 gcg tac cac cca cta ctc tat gag aag ctc ctg gtg cag cgc ctg aac     1725
 Ala Tyr His Pro Leu Leu Tyr Glu Lys Leu Leu Val Gln Arg Leu Asn
                 485                 490                 495

 atg ggc acg cag ggg gat ttg cat cgc aag ggc aag gtg gtt ctt ccc     1773
 Met Gly Thr Gln Gly Asp Leu His Arg Lys Gly Lys Val Val Leu Pro
             500                 505                 510

 ggc ttc cag gcg gtg cac tgc cct gca cca agt cca gtc att cca cac     1821
 Gly Phe Gln Ala Val His Cys Pro Ala Pro Ser Pro Val Ile Pro His
         515                 520                 525

 tct taa aaagggtttc ttgggaatca atgtgcaata aggtactact gttgtactca      1877
 Ser 


 aagtcacaaa agaatacttg aagatagatt ttagacagtg tagttttgag tctttaaaca   1937

 gtaatttagt ggtggtcatg ataatccttc tctttctaag ccattgagta tgtattactg   1997

 ctttgaacat agaaatggtt tttttaaaaa aataaggctc aagaaagatg caaaaccaag   2057

 gatagctaga aagaaaacac atgtatgacc atgggtatga tacctccaga aatggttaac   2117

 aacttattct tctgccatga gtacccctca tccagggttg gtttcaatga caggttttgg   2177

 tgatgttcct gaccatatga agtggtttat gtttagaaac attcaaattg agggacatca   2237

 tttacagcat cgagtgtgtc agttatacat gcattcatca ttaaatatcc tagg         2291




      <210> 392
      <211> 1808
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(1298)

      <400> 392
 gtgcacgtgc gcacggcgac ggccgg atg gct gcg tgg ggc tgt gtg gct gcg      53
                              Met Ala Ala Trp Gly Cys Val Ala Ala
                                1               5

 ctc ggc gcg gcg cgt ggg ctt tgc tgg cgg gcg gcg cgc gcg gct gcg      101
 Leu Gly Ala Ala Arg Gly Leu Cys Trp Arg Ala Ala Arg Ala Ala Ala
  10                  15                  20                  25

 ggg ctc cag ggc cgc ccc gcc cgc agg tgc tat gct gtg ggc ccc gct      149
 Gly Leu Gln Gly Arg Pro Ala Arg Arg Cys Tyr Ala Val Gly Pro Ala
                  30                  35                  40

 cag agc cca ccc acc ttt ggg ttc ctg ttg gac atc gat gga gtg ctt      197
 Gln Ser Pro Pro Thr Phe Gly Phe Leu Leu Asp Ile Asp Gly Val Leu
              45                  50                  55

 gtg cgg ggc cac aga gtg atc cct gct gct ctg aaa gcc ttc cga agg      245
 Val Arg Gly His Arg Val Ile Pro Ala Ala Leu Lys Ala Phe Arg Arg
          60                  65                  70

 ctg gtg aac tcc cag ggg cag ctg cgg gtg ccc gtg gtt ttt gtt aca      293
 Leu Val Asn Ser Gln Gly Gln Leu Arg Val Pro Val Val Phe Val Thr
      75                  80                  85

 aat gct ggg aac atc tta caa cac agc aaa gcc cag gag ctg tca gcc      341
 Asn Ala Gly Asn Ile Leu Gln His Ser Lys Ala Gln Glu Leu Ser Ala
  90                  95                 100                 105

 ctg ctg ggg tgc gag gtg gat gca gac caa gtt atc ctc tct cac agc      389
 Leu Leu Gly Cys Glu Val Asp Ala Asp Gln Val Ile Leu Ser His Ser
                 110                 115                 120

 ccc atg aag ctc ttc tcc gag tac cat gag aag cgg atg ctg gtg tct      437
 Pro Met Lys Leu Phe Ser Glu Tyr His Glu Lys Arg Met Leu Val Ser
             125                 130                 135

 gga cag ggg ccc gtg atg gaa aat gcc cag gga ctg ggc ttc cga aat      485
 Gly Gln Gly Pro Val Met Glu Asn Ala Gln Gly Leu Gly Phe Arg Asn
         140                 145                 150

 gtc gtc acc gtg gat gag ctg cgg atg gcc ttt cct ctg ctt gac atg      533
 Val Val Thr Val Asp Glu Leu Arg Met Ala Phe Pro Leu Leu Asp Met
     155                 160                 165

 gtg gac ctg gag cgg cgg cta aag acc acg ccc ctc ccg agg aat gac      581
 Val Asp Leu Glu Arg Arg Leu Lys Thr Thr Pro Leu Pro Arg Asn Asp
 170                 175                 180                 185

 ttc ccc cgc att gaa ggg gtg ctc ctc cta ggg gag ccg gtc cgc tgg      629
 Phe Pro Arg Ile Glu Gly Val Leu Leu Leu Gly Glu Pro Val Arg Trp
                 190                 195                 200

 gag acc agc ctg cag ctg atc atg gat gtc ctc ctc agc aat ggg agc      677
 Glu Thr Ser Leu Gln Leu Ile Met Asp Val Leu Leu Ser Asn Gly Ser
             205                 210                 215

 cct ggg gct ggc ctg gca aca ccc ccc tac ccc cac ctc ccc gtc cta      725
 Pro Gly Ala Gly Leu Ala Thr Pro Pro Tyr Pro His Leu Pro Val Leu
         220                 225                 230

 gcc agc aac atg gat ctc ctg tgg atg gct gaa gcc aag atg ccc agg      773
 Ala Ser Asn Met Asp Leu Leu Trp Met Ala Glu Ala Lys Met Pro Arg
     235                 240                 245

 ttt gga cat ggc acc ttt ctg ctg tgc ctg gaa acc att tac cag aaa      821
 Phe Gly His Gly Thr Phe Leu Leu Cys Leu Glu Thr Ile Tyr Gln Lys
 250                 255                 260                 265

 gtg acg ggc aag gag ctg aga tac gag ggc ctg atg ggc aaa ccc agc      869
 Val Thr Gly Lys Glu Leu Arg Tyr Glu Gly Leu Met Gly Lys Pro Ser
                 270                 275                 280

 atc ctc act tac cag tat gcc gag gac ctg atc agg cga cag gcg gag      917
 Ile Leu Thr Tyr Gln Tyr Ala Glu Asp Leu Ile Arg Arg Gln Ala Glu
             285                 290                 295

 agg cgg ggc tgg gcc gcc ccc atc cgg aag ctc tat gct gtg ggt gat      965
 Arg Arg Gly Trp Ala Ala Pro Ile Arg Lys Leu Tyr Ala Val Gly Asp
         300                 305                 310

 aac cct atg tct gac gta tac ggc gcc aac ctg ttc cac cag tac ctg     1013
 Asn Pro Met Ser Asp Val Tyr Gly Ala Asn Leu Phe His Gln Tyr Leu
     315                 320                 325

 cag aag gca acg cat gat ggg gcg cca gaa cta ggg gcc ggg ggc aca     1061
 Gln Lys Ala Thr His Asp Gly Ala Pro Glu Leu Gly Ala Gly Gly Thr
 330                 335                 340                 345

 cgg cag caa cag ccc tca gca agc cag agc tgc atc tcc atc ctg gtg     1109
 Arg Gln Gln Gln Pro Ser Ala Ser Gln Ser Cys Ile Ser Ile Leu Val
                 350                 355                 360

 tgt aca ggc gtc tac aat ccc agg aac cca cag tcc acg gag cct gtc     1157
 Cys Thr Gly Val Tyr Asn Pro Arg Asn Pro Gln Ser Thr Glu Pro Val
             365                 370                 375

 ctt gga gga ggg gag cct cca ttc cac ggg cac cga gac tta tgc ttc     1205
 Leu Gly Gly Gly Glu Pro Pro Phe His Gly His Arg Asp Leu Cys Phe
         380                 385                 390

 agt cca ggg ctc atg gag gcc tcc cac gtg gtg aat gac gtg aat gag     1253
 Ser Pro Gly Leu Met Glu Ala Ser His Val Val Asn Asp Val Asn Glu
     395                 400                 405

 gct gtg cag ctg gtc ttc cgc aag gag ggc tgg gct ttg gag tga ggg     1301
 Ala Val Gln Leu Val Phe Arg Lys Glu Gly Trp Ala Leu Glu 
 410                 415                 420

 cagtgcggtg gaggtgaggg ggtgagcctg gacctgtggg cgagtcccat tggctgggct   1361

 ctggcctgat cactgggctc aggtcagggc ttggttccct tgccaccctt cttgctgccc   1421

 catgagtgtg gcattactgg tcacttggaa gaagacagtg actctttttc cctgctgggt   1481

 agcattttgt atggaacggt tggaattttc tgggcccagt tcccacgtgc ctttcgtggc   1541

 agtctaacct caggccattc tcttcccctg tgtgcctcag tgtccttctc atttcagtag   1601

 ggacttctga aatgggggag gcagtgtgga atactgtgga tgtctgtgca gagcctttgc   1661

 cggcactgaa ggcatgcagc ctgtcggcag agtgtcttaa caccagatgc tactttttac   1721

 tgtattgtag tttattgccc ggagatgtgg ggcttttttt ttaaataaaa taatcataat   1781

 aaatgttcat gatgctgaaa aaaaaaa                                       1808




      <210> 393
      <211> 1082
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (14)..(1081)

      <400> 393
 cggcgacggc cgg   atg gct gcg tgg ggc tgt gtg gct gcg ctc ggc gcg      49
                  Met Ala Ala Trp Gly Cys Val Ala Ala Leu Gly Ala
                    1               5                  10

 gcg cgt ggg ctt tgc tgg cgg gcg gcg cgc gcg gct gcg ggg ctc cag       97
 Ala Arg Gly Leu Cys Trp Arg Ala Ala Arg Ala Ala Ala Gly Leu Gln
          15                  20                  25

 ggc cgc ccc gcc cgc agg tgc tat gct gtg ggc ccc gct cag gtg gat      145
 Gly Arg Pro Ala Arg Arg Cys Tyr Ala Val Gly Pro Ala Gln Val Asp
      30                  35                  40

 gca gac caa gtt atc ctc tct cac agc ccc atg aag ctc ttc tcc gag      193
 Ala Asp Gln Val Ile Leu Ser His Ser Pro Met Lys Leu Phe Ser Glu
  45                  50                  55                  60

 tac cat gag aag cgg atg ctg gtg tct gga cag ggg ccc gtg atg gaa      241
 Tyr His Glu Lys Arg Met Leu Val Ser Gly Gln Gly Pro Val Met Glu
                  65                  70                  75

 aat gcc cag gga ctg ggc ttc cga aat gtc gtc acc gtg gat gag ctg      289
 Asn Ala Gln Gly Leu Gly Phe Arg Asn Val Val Thr Val Asp Glu Leu
              80                  85                  90

 cgg atg gcc ttt cct ctg ctt gac atg gtg gac ctg gag cgg cgg cta      337
 Arg Met Ala Phe Pro Leu Leu Asp Met Val Asp Leu Glu Arg Arg Leu
          95                 100                 105

 aag acc acg ccc ctc ccg agg aat gac ttc ccc cgc att gaa ggg gtg      385
 Lys Thr Thr Pro Leu Pro Arg Asn Asp Phe Pro Arg Ile Glu Gly Val
     110                 115                 120

 ctc ctc cta ggg gag ccg gtc cgc tgg gag acc agc ctg cag ctg atc      433
 Leu Leu Leu Gly Glu Pro Val Arg Trp Glu Thr Ser Leu Gln Leu Ile
 125                 130                 135                 140

 atg gat gtc ctc ctc agc aat ggg agc cct ggg gct ggc ctg gca aca      481
 Met Asp Val Leu Leu Ser Asn Gly Ser Pro Gly Ala Gly Leu Ala Thr
                 145                 150                 155

 ccc ccc tac ccc cac ctc ccc gtc cta gcc agc aac atg gat ctc ctg      529
 Pro Pro Tyr Pro His Leu Pro Val Leu Ala Ser Asn Met Asp Leu Leu
             160                 165                 170

 tgg atg gct gaa gcc aag atg ccc agg ttt gga cat ggc acc ttt ctg      577
 Trp Met Ala Glu Ala Lys Met Pro Arg Phe Gly His Gly Thr Phe Leu
         175                 180                 185

 ctg tgc ctg gaa acc att tac cag aaa gtg acg ggc aag gag ctg aga      625
 Leu Cys Leu Glu Thr Ile Tyr Gln Lys Val Thr Gly Lys Glu Leu Arg
     190                 195                 200

 tac gag ggc ctg atg ggc aaa ccc agc atc ctc act tac cag tat gcc      673
 Tyr Glu Gly Leu Met Gly Lys Pro Ser Ile Leu Thr Tyr Gln Tyr Ala
 205                 210                 215                 220

 gag gac ctg atc agg cga cag gcg gag agg cgg ggc tgg gcc gcc ccc      721
 Glu Asp Leu Ile Arg Arg Gln Ala Glu Arg Arg Gly Trp Ala Ala Pro
                 225                 230                 235

 atc cgg aag ctc tat gct gtg ggt gat aac cct atg tct gac gta tac      769
 Ile Arg Lys Leu Tyr Ala Val Gly Asp Asn Pro Met Ser Asp Val Tyr
             240                 245                 250

 ggc gcc aac ctg ttc cac cag tac ctg cag aag gca acg cat gat ggg      817
 Gly Ala Asn Leu Phe His Gln Tyr Leu Gln Lys Ala Thr His Asp Gly
         255                 260                 265

 gcg cca gaa cta ggg gcc ggg ggc aca cgg cag caa cag ccc tca gca      865
 Ala Pro Glu Leu Gly Ala Gly Gly Thr Arg Gln Gln Gln Pro Ser Ala
     270                 275                 280

 agc cag agc tgc atc tcc atc ctg gtg tgt aca ggc gtc tac aat ccc      913
 Ser Gln Ser Cys Ile Ser Ile Leu Val Cys Thr Gly Val Tyr Asn Pro
 285                 290                 295                 300

 agg aac cca cag tcc acg gag cct gtc ctt gga gga ggg gag cct cca      961
 Arg Asn Pro Gln Ser Thr Glu Pro Val Leu Gly Gly Gly Glu Pro Pro
                 305                 310                 315

 ttc cac ggg cac cga gac tta tgc ttc agt cca ggg ctc atg gag gcc     1009
 Phe His Gly His Arg Asp Leu Cys Phe Ser Pro Gly Leu Met Glu Ala
             320                 325                 330

 tcc cac gtg gtg aat gac gtg aat gag gct gtg cag ctg gtc ttc cgc     1057
 Ser His Val Val Asn Asp Val Asn Glu Ala Val Gln Leu Val Phe Arg
         335                 340                 345

 aag gag ggc tgg gct ttg gag tga g                                   1082
 Lys Glu Gly Trp Ala Leu Glu 
     350                 355





      <210> 394
      <211> 4527
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4527)

      <400> 394
  atg tgg gct cag ctc ctt cta gga atg ttg gcc cta tca cca gcc att      48
  Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile
    1               5                  10                  15

 gca gaa gaa ctt cca aac tac ctg gtg aca tta cca gcc cgg cta aat       96
 Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn
              20                  25                  30

 ttc ccc tcc gtt cag aag gtt tgt ttg gac ctg agc cct ggg tac agt      144
 Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser
          35                  40                  45

 gat gtt aaa ttc acg gtt act ctg gag acc aag gac aag acc cag aag      192
 Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys
      50                  55                  60

 ttg cta gaa tac tct gga ctg aag aag agg cac tta cat tgt atc tcc      240
 Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser
  65                  70                  75                  80

 ttt ctt gta cca cct cct gct ggt ggc aca gaa gaa gtg gcc aca atc      288
 Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile
                  85                  90                  95

 cgg gtg tcg gga gtt gga aat aac atc agc ttt gag gag aag aaa aag      336
 Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys
             100                 105                 110

 gtt cta att cag agg cag ggg aac ggc acc ttt gta cag act gac aaa      384
 Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys
         115                 120                 125

 cct ctc tac acc cca ggg cag caa gtg tat ttc cgc att gtc acc atg      432
 Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met
     130                 135                 140

 gat agc aac ttc gtt cca gtg aat gac aag tac tcc atg gtg gaa cta      480
 Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu
 145                 150                 155                 160

 cag gat cca aat agc aac agg att gca cag tgg ctg gaa gtg gta cct      528
 Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro
                 165                 170                 175

 gag caa ggc att gta gac ctg tcc ttc caa ctg gca cca gag gca atg      576
 Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met
             180                 185                 190

 ctg ggc acc tac act gtg gca gtg gct gag ggc aag acc ttt ggt act      624
 Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr
         195                 200                 205

 ttc agt gtg gag gaa tat gtg ctg ccg aag ttt aag gtg gaa gtg gtg      672
 Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val
     210                 215                 220

 gaa ccc aag gag tta tca acg gtg cag gaa tct ttc tta gta aaa att      720
 Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile
 225                 230                 235                 240

 tgt tgt agg tac acc tat gga aag ccc atg cta ggg gca gtg cag gta      768
 Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val
                 245                 250                 255

 tct gtg tgt cag aag gca aat act tac tgg tat cga gag gtg gaa cgg      816
 Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg
             260                 265                 270

 gaa cag ctt cct gac aaa tgc agg aac ctc tct gga cag act gac aaa      864
 Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys
         275                 280                 285

 aca gga tgt ttc tca gca cct gtg gac atg gcc acc ttt gac ctc att      912
 Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile
     290                 295                 300

 gga tat gcg tac agc cat caa atc aat att gtg gct act gtt gtg gag      960
 Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu
 305                 310                 315                 320

 gaa ggg aca ggt gtg gag gcc aat gcc act cag aat atc tac att tct     1008
 Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser
                 325                 330                 335

 cca caa atg gga tca atg acc ttt gaa gac acc agc aat ttt tac cat     1056
 Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His
             340                 345                 350

 cca aat ttc ccc ttc agt ggg aag ata aga gtt agg ggc cat gat gac     1104
 Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp
         355                 360                 365

 tcc ttc ctc aag aac cat cta gtg ttt ctg gtg att tat ggc aca aat     1152
 Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn
     370                 375                 380

 gga acc ttc aac cag acc ctg gtt act gat aac aat ggc cta gct ccc     1200
 Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro
 385                 390                 395                 400

 ttt acc ttg gag aca tcc ggt tgg aat ggg aca gac gtt tct ctg gag     1248
 Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu
                 405                 410                 415

 gga aag ttt caa atg gaa gac tta gta tat aat ccg gaa caa gtg cca     1296
 Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro
             420                 425                 430

 cgt tac tac caa aat gcc tac ctg cac ctg cga ccc ttc tac agc aca     1344
 Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr
         435                 440                 445

 acc cgc agc ttc ctt ggc atc cac cgg cta aac ggc ccc ttg aaa tgt     1392
 Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys
     450                 455                 460

 ggc cag ccc cag gaa gtg ctg gtg gat tat tac atc gac ccg gcc gat     1440
 Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp
 465                 470                 475                 480

 gca agc cct gac caa gag atc agc ttc tcc tac tat tta ata ggg aaa     1488
 Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys
                 485                 490                 495

 gga agt ttg gtg atg gag ggg cag aaa cac ctg aac tct aag aag aaa     1536
 Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys
             500                 505                 510

 gga ctg aaa gcc tcc ttc tct ctc tca ctg acc ttc act tcg aga ctg     1584
 Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu
         515                 520                 525

 gcc cct gat cct tcc ctg gtg atc tat gcc att ttt ccc agt gga ggt     1632
 Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly
     530                 535                 540

 gtt gta gct gac aaa att cag ttc tca gtc ggg atg tgc ttt gac aat     1680
 Val Val Ala Asp Lys Ile Gln Phe Ser Val Gly Met Cys Phe Asp Asn
 545                 550                 555                 560

 cag gtt tcc ctt ggc ttc tcc ccc tcc cag cag ctt cca gga gca gaa     1728
 Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu
                 565                 570                 575

 gtg gag ctg cag ctg cag gca gct ccc gga tcc ctg tgt gcg ctc cgg     1776
 Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg
             580                 585                 590

 gcg gtg gat gag agt gtc tta ctg ctt agg cca gac aga gag ctg agc     1824
 Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser
         595                 600                 605

 aac cgc tct gtc tat ggg atg ttt cca ttc tgg tat ggt cac tac ccc     1872
 Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro
     610                 615                 620

 tat caa gtg gct gag tat gat cag tgt cca gtg tct ggc cca tgg gac     1920
 Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp
 625                 630                 635                 640

 ttt cct cag ccc ctc att gac cca atg ccc caa ggg cat tcg agc cag     1968
 Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln
                 645                 650                 655

 cgt tcc att atc tgg agg ccc tcg ttc tct gaa ggc acg gac ctt ttc     2016
 Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe
             660                 665                 670

 agc ttt ttc cgg gac gtg ggc ctg aaa ata ctg tcc aat gcc aaa atc     2064
 Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile
         675                 680                 685

 aag aag cca gta gat tgc agt cac aga tct cca gaa tac agc act gct     2112
 Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala
     690                 695                 700

 atg ggt ggc ggt ggt cat cca gag gct ttt gag tca tca act cct tta     2160
 Met Gly Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro Leu
 705                 710                 715                 720

 cat caa gca gag gat tct cag gtc cgc cag tac ttc cca gag acc tgg     2208
 His Gln Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr Trp
                 725                 730                 735

 ctc tgg gat ctg ttt cct att ggt aac tcg ggg aag gag gcg gtc cac     2256
 Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val His
             740                 745                 750

 gtc aca gtt cct gac gcc atc acc gag tgg aag gcg atg agt ttc tgc     2304
 Val Thr Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe Cys
         755                 760                 765

 act tcc cag tca aga ggc ttc ggg ctt tca ccc act gtt gga cta act     2352
 Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu Thr
     770                 775                 780

 gct ttc aag ccg ttc ttt gtt gac ctg act ctc cct tac tca gta gtc     2400
 Ala Phe Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val Val
 785                 790                 795                 800

 cgt ggg gaa tcc ttt cgt ctt act gcc acc atc ttc aat tac cta aag     2448
 Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu Lys
                 805                 810                 815

 gat tgc atc agg gtt cag act gac ctg gct aaa tcg cat gag tac cag     2496
 Asp Cys Ile Arg Val Gln Thr Asp Leu Ala Lys Ser His Glu Tyr Gln
             820                 825                 830

 cta gaa tca tgg gca gat tct cag acc tcc agt tgt ctc tgt gct gat     2544
 Leu Glu Ser Trp Ala Asp Ser Gln Thr Ser Ser Cys Leu Cys Ala Asp
         835                 840                 845

 gac gca aaa acc cac cac tgg aac atc aca gct gtc aaa ttg ggt cac     2592
 Asp Ala Lys Thr His His Trp Asn Ile Thr Ala Val Lys Leu Gly His
     850                 855                 860

 att aac ttt act att agt aca aag att ctg gac agc aat gaa cca tgt     2640
 Ile Asn Phe Thr Ile Ser Thr Lys Ile Leu Asp Ser Asn Glu Pro Cys
 865                 870                 875                 880

 ggg ggc cag aag ggg ttt gtt ccc caa aag ggc cga agt gac acg ctc     2688
 Gly Gly Gln Lys Gly Phe Val Pro Gln Lys Gly Arg Ser Asp Thr Leu
                 885                 890                 895

 atc aag cca gtt ctc gtc aaa cct gag gga gtc ctg gtg gag aag aca     2736
 Ile Lys Pro Val Leu Val Lys Pro Glu Gly Val Leu Val Glu Lys Thr
             900                 905                 910

 cac agc tca ttg ctg tgc cca aaa gga aag gtg gca tct gaa tct gtc     2784
 His Ser Ser Leu Leu Cys Pro Lys Gly Lys Val Ala Ser Glu Ser Val
         915                 920                 925

 tcc ctg gag ctc cca gtg gac att gtt cct gac tcg acc aag gct tat     2832
 Ser Leu Glu Leu Pro Val Asp Ile Val Pro Asp Ser Thr Lys Ala Tyr
     930                 935                 940

 gtt acg gtt ctg ggt aag cag tta gag att ctt gac tca gaa agg aaa     2880
 Val Thr Val Leu Gly Lys Gln Leu Glu Ile Leu Asp Ser Glu Arg Lys
 945                 950                 955                 960

 agg cga atg gag gct gca aag gtg tgg aga gac att atg ggc aca gcc     2928
 Arg Arg Met Glu Ala Ala Lys Val Trp Arg Asp Ile Met Gly Thr Ala
                 965                 970                 975

 ctg cag aac ctg gat ggt ctg gtg cag atg ccc agt ggc tgt ggc gag     2976
 Leu Gln Asn Leu Asp Gly Leu Val Gln Met Pro Ser Gly Cys Gly Glu
             980                 985                 990

 cag aac atg gtc ttg ttt gct ccc atc atc tat gtc ttg cag tac ctg     3024
 Gln Asn Met Val Leu Phe Ala Pro Ile Ile Tyr Val Leu Gln Tyr Leu
         995                1000                1005

 gag aag gca ggg ctg ctg acg gag gag atc agg tct cgg gca gtg ggt     3072
 Glu Lys Ala Gly Leu Leu Thr Glu Glu Ile Arg Ser Arg Ala Val Gly
    1010                1015                1020

 ttc ctg gaa ata ggg tac cag aag gag ctg atg tac aaa cac agc aat     3120
 Phe Leu Glu Ile Gly Tyr Gln Lys Glu Leu Met Tyr Lys His Ser Asn
1025                1030                1035                1040

 ggc tca tac agt gcc ttt ggg gag cga gat gga aat gga aac aca tgg     3168
 Gly Ser Tyr Ser Ala Phe Gly Glu Arg Asp Gly Asn Gly Asn Thr Trp
                1045                1050                1055

 ctg aca gcg ttt gtc aca aaa tgc ttt ggc caa gct cag aaa ttc atc     3216
 Leu Thr Ala Phe Val Thr Lys Cys Phe Gly Gln Ala Gln Lys Phe Ile
            1060                1065                1070

 ttc att gat ccc aag aac atc cag gat gct ctc aag tgg atg gca gga     3264
 Phe Ile Asp Pro Lys Asn Ile Gln Asp Ala Leu Lys Trp Met Ala Gly
        1075                1080                1085

 aac cag ctc ccc agt ggc tgc tat gcc aac gtg gga aat ctc ctt cac     3312
 Asn Gln Leu Pro Ser Gly Cys Tyr Ala Asn Val Gly Asn Leu Leu His
    1090                1095                1100

 aca gct atg aag ggt ggt gtt gat gat gag gtc tcc ttg act gcg tat     3360
 Thr Ala Met Lys Gly Gly Val Asp Asp Glu Val Ser Leu Thr Ala Tyr
1105                1110                1115                1120

 gtc aca gct gca ttg ctg gag atg gga aag gat gta gat gac cca atg     3408
 Val Thr Ala Ala Leu Leu Glu Met Gly Lys Asp Val Asp Asp Pro Met
                1125                1130                1135

 gtg agt cag ggt cta cgg tgt ctc aag aat tcg gcc acc tcc acg acc     3456
 Val Ser Gln Gly Leu Arg Cys Leu Lys Asn Ser Ala Thr Ser Thr Thr
            1140                1145                1150

 aac ctc tac aca cag gcc ctg ttg gct tac att ttc tcc ctg gct ggg     3504
 Asn Leu Tyr Thr Gln Ala Leu Leu Ala Tyr Ile Phe Ser Leu Ala Gly
        1155                1160                1165

 gaa atg gac atc aga aac att ctc ctt aaa cag tta gat caa cag gct     3552
 Glu Met Asp Ile Arg Asn Ile Leu Leu Lys Gln Leu Asp Gln Gln Ala
    1170                1175                1180

 atc atc tca gga gaa tcc att tac tgg agc cag aaa cct act cca tca     3600
 Ile Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser
1185                1190                1195                1200

 tcg aac gcc agc cct tgg tct gag cct gcg gct gta gat gtg gaa ctc     3648
 Ser Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu
                1205                1210                1215

 aca gca tat gca ttg ttg gcc cag ctt acc aag ccc agc ctg act caa     3696
 Thr Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln
            1220                1225                1230

 aag gag ata gcg aag gcc act agc ata gtg gct tgg ttg gcc aag caa     3744
 Lys Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln
        1235                1240                1245

 cac aat gca tat ggg ggc ttc tct tct act cag gat act gta gtt gct     3792
 His Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala
    1250                1255                1260

 ctc caa gct ctt gcc aaa tat gcc act acc gcc tac atg cca tct gag     3840
 Leu Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Met Pro Ser Glu
1265                1270                1275                1280

 gag atc aac ctg gtt gta aaa tcc act gag aat ttc cag cgc aca ttc     3888
 Glu Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe
                1285                1290                1295

 aac ata cag tca gtt aac aga ttg gta ttt cag cag gat acc ctg ccc     3936
 Asn Ile Gln Ser Val Asn Arg Leu Val Phe Gln Gln Asp Thr Leu Pro
            1300                1305                1310

 aat gtc cct gga atg tac acg ttg gag gcc tca ggc cag ggc tgt gtc     3984
 Asn Val Pro Gly Met Tyr Thr Leu Glu Ala Ser Gly Gln Gly Cys Val
        1315                1320                1325

 tat gtg cag acg gtg ttg aga tac aat att ctc cct ccc aca aat atg     4032
 Tyr Val Gln Thr Val Leu Arg Tyr Asn Ile Leu Pro Pro Thr Asn Met
    1330                1335                1340

 aag acc ttt agt ctt agt gtg gaa ata gga aaa gct aga tgt gag caa     4080
 Lys Thr Phe Ser Leu Ser Val Glu Ile Gly Lys Ala Arg Cys Glu Gln
1345                1350                1355                1360

 ccg act tca cct cga tcc ttg act ctc act att cac acc agt tat gtg     4128
 Pro Thr Ser Pro Arg Ser Leu Thr Leu Thr Ile His Thr Ser Tyr Val
                1365                1370                1375

 ggg agc cgt agc tct tcc aat atg gct att gtg gaa gtg aag atg cta     4176
 Gly Ser Arg Ser Ser Ser Asn Met Ala Ile Val Glu Val Lys Met Leu
            1380                1385                1390

 tct ggg ttc agt ccc atg gag ggc acc aat cag tta ctt ctc cag caa     4224
 Ser Gly Phe Ser Pro Met Glu Gly Thr Asn Gln Leu Leu Leu Gln Gln
        1395                1400                1405

 ccc ctg gtg aag aag gtt gaa ttt gga act gac aca ctt aac att tac     4272
 Pro Leu Val Lys Lys Val Glu Phe Gly Thr Asp Thr Leu Asn Ile Tyr
    1410                1415                1420

 ttg gat gag ctc att aag aac act cag act tac acc ttc acc atc agc     4320
 Leu Asp Glu Leu Ile Lys Asn Thr Gln Thr Tyr Thr Phe Thr Ile Ser
1425                1430                1435                1440

 caa agt gtg ctg gtc acc aac ttg aaa cca gca acc atc aag gtc tat     4368
 Gln Ser Val Leu Val Thr Asn Leu Lys Pro Ala Thr Ile Lys Val Tyr
                1445                1450                1455

 gac tac tac cta cca ggt tct ttt aaa tta tct cag tac aca att gtg     4416
 Asp Tyr Tyr Leu Pro Gly Ser Phe Lys Leu Ser Gln Tyr Thr Ile Val
            1460                1465                1470

 tgg tcc atg aac aat gac agc ata gtg gac tct gtg gca cgg cac cca     4464
 Trp Ser Met Asn Asn Asp Ser Ile Val Asp Ser Val Ala Arg His Pro
        1475                1480                1485

 gaa cca ccc cct ttc aag aca gaa gca ttt att cct tca ctt cct ggg     4512
 Glu Pro Pro Pro Phe Lys Thr Glu Ala Phe Ile Pro Ser Leu Pro Gly
    1490                1495                1500

 agt gtt aac aac tga                                                 4527
 Ser Val Asn Asn 
1505





      <210> 395
      <211> 3405
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(2828)

      <400> 395
 aatcccctta ctataggctc gagcgccccc ggcagattgg ttttatttgc tgttacacaa     60

 acaacactac ataaaacatt ttttgctaa  atg ata gtt tat aaa ttt gta cct     113
                                  Met Ile Val Tyr Lys Phe Val Pro
                                    1               5

 gtc tca ccc aca aag atg tgg gct cag ctc ctt cta gga atg ttg gcc      161
 Val Ser Pro Thr Lys Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala
      10                  15                  20

 cta tca cca gcc att gca gaa gaa ctt cca aac tac ctg gtg aca tta      209
 Leu Ser Pro Ala Ile Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu
  25                  30                  35                  40

 cca gcc cgg cta aat ttc ccc tcc gtt cag aag gtt tgt ttg gac ctg      257
 Pro Ala Arg Leu Asn Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu
                  45                  50                  55

 agc cct ggg tac agt gat gtt aaa ttc acg gtt act ctg gag acc aag      305
 Ser Pro Gly Tyr Ser Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys
              60                  65                  70

 gac aag acc cag aag ttg cta gaa tac tct gga ctg aag aag agg cac      353
 Asp Lys Thr Gln Lys Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His
          75                  80                  85

 tta cat tgt atc tcc ttt ctt gta cca cct cct gct ggt ggc aca gaa      401
 Leu His Cys Ile Ser Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu
      90                  95                 100

 gaa gtg gcc aca atc cgg gtg tcg gga gtt gga aat aac atc agc ttt      449
 Glu Val Ala Thr Ile Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe
 105                 110                 115                 120

 gag gag aag aaa aag gtt cta att cag agg cag ggg aac ggc acc ttt      497
 Glu Glu Lys Lys Lys Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe
                 125                 130                 135

 gta cag act gac aaa cct ctc tac acc cca ggg cag caa gtg tat ttc      545
 Val Gln Thr Asp Lys Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe
             140                 145                 150

 cgc att gtc acc atg gat agc aac ttc gtt cca gtg aat gac aag tac      593
 Arg Ile Val Thr Met Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr
         155                 160                 165

 tcc atg gtg gaa cta cag gat cca aat agc aac agg att gca cag tgg      641
 Ser Met Val Glu Leu Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp
     170                 175                 180

 ctg gaa gtg gta cct gag caa ggc att gta gac ctg tcc ttc caa ctg      689
 Leu Glu Val Val Pro Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu
 185                 190                 195                 200

 gca cca gag gca atg ctg ggc acc tac act gtg gca gtg gct gag ggc      737
 Ala Pro Glu Ala Met Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly
                 205                 210                 215

 aag acc ttt ggt act ttc agt gtg gag gaa tat gtg ctg ccg aag ttt      785
 Lys Thr Phe Gly Thr Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe
             220                 225                 230

 aag gtg gaa gtg gtg gaa ccc aag gag tta tca acg gtg cag gaa tct      833
 Lys Val Glu Val Val Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser
         235                 240                 245

 ttc tta gta aaa att tgt tgt agg tac acc tat gga aag ccc atg cta      881
 Phe Leu Val Lys Ile Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu
     250                 255                 260

 ggg gca gtg cag gta tct gtg tgt cag aag gca aat act tac tgg tat      929
 Gly Ala Val Gln Val Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr
 265                 270                 275                 280

 cga gag gtg gaa cgg gaa cag ctt cct gac aaa tgc agg aac ctc tct      977
 Arg Glu Val Glu Arg Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser
                 285                 290                 295

 gga cag act gac aaa aca gga tgt ttc tca gca cct gtg gac atg gcc     1025
 Gly Gln Thr Asp Lys Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala
             300                 305                 310

 acc ttt gac ctc att gga tat gcg tac agc cat caa atc aat att gtg     1073
 Thr Phe Asp Leu Ile Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val
         315                 320                 325

 gct act gtt gtg gag gaa ggg aca ggt gtg gag gcc aat gcc act cag     1121
 Ala Thr Val Val Glu Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln
     330                 335                 340

 aat atc tac att tct cca caa atg gga tca atg acc ttt gaa gac acc     1169
 Asn Ile Tyr Ile Ser Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr
 345                 350                 355                 360

 agc aat ttt tac cat cca aat ttc ccc ttc agt ggg aag ata aga gtt     1217
 Ser Asn Phe Tyr His Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val
                 365                 370                 375

 agg ggc cat gat gac tcc ttc ctc aag aac cat cta gtg ttt ctg gtg     1265
 Arg Gly His Asp Asp Ser Phe Leu Lys Asn His Leu Val Phe Leu Val
             380                 385                 390

 att tat ggc aca aat gga acc ttc aac cag acc ctg gtt act gat aac     1313
 Ile Tyr Gly Thr Asn Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn
         395                 400                 405

 aat ggc cta gct ccc ttt acc ttg gag aca tcc ggt tgg aat ggg aca     1361
 Asn Gly Leu Ala Pro Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr
     410                 415                 420

 gac gtt tct ctg gag gga aag ttt caa atg gaa gac tta gta tat aat     1409
 Asp Val Ser Leu Glu Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn
 425                 430                 435                 440

 ccg gaa caa gtg cca cgt tac tac caa aat gcc tac ctg cac ctg cga     1457
 Pro Glu Gln Val Pro Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg
                 445                 450                 455

 ccc ttc tac agc aca acc cgc agc ttc ctt ggc atc cac cgg cta aac     1505
 Pro Phe Tyr Ser Thr Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn
             460                 465                 470

 ggc ccc ttg aaa tgt ggc cag ccc cag gaa gtg ctg gtg gat tat tac     1553
 Gly Pro Leu Lys Cys Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr
         475                 480                 485

 atc gac ccg gcc gat gca agc cct gac caa gag atc agc ttc tcc tac     1601
 Ile Asp Pro Ala Asp Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr
     490                 495                 500

 tat tta ata ggg aaa gga agt ttg gtg atg gag ggg cag aaa cac ctg     1649
 Tyr Leu Ile Gly Lys Gly Ser Leu Val Met Glu Gly Gln Lys His Leu
 505                 510                 515                 520

 aac tct aag aag aaa gga ctg aaa gcc tcc ttc tct ctc tca ctg acc     1697
 Asn Ser Lys Lys Lys Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr
                 525                 530                 535

 ttc act tcg aga ctg gcc cct gat cct tcc ctg gtg atc tat gcc att     1745
 Phe Thr Ser Arg Leu Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile
             540                 545                 550

 ttt ccc agt gga ggt gtt gta gct gac aaa att cag ttc tca gtc gag     1793
 Phe Pro Ser Gly Gly Val Val Ala Asp Lys Ile Gln Phe Ser Val Glu
         555                 560                 565

 atg tgc ttt gac aat cag gtt tcc ctt ggc ttc tcc ccc tcc cag cag     1841
 Met Cys Phe Asp Asn Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln
     570                 575                 580

 ctt cca gga gca gaa gtg gag ctg cag ctg cag gca gct ccc gga tcc     1889
 Leu Pro Gly Ala Glu Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser
 585                 590                 595                 600

 ctg tgt gcg ctc cgg gcg gtg gat gag agt gtc tta ctg ctt agg cca     1937
 Leu Cys Ala Leu Arg Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro
                 605                 610                 615

 gac aga gag ctg agc aac cgc tct gtc tat ggg atg ttt cca ttc tgg     1985
 Asp Arg Glu Leu Ser Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp
             620                 625                 630

 tat ggt cac tac ccc tat caa gtg gct gag tat gat cag tgt cca gtg     2033
 Tyr Gly His Tyr Pro Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val
         635                 640                 645

 tct ggc cca tgg gac ttt cct cag ccc ctc att gac cca atg ccc caa     2081
 Ser Gly Pro Trp Asp Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln
     650                 655                 660

 ggg cat tcg agc cag cgt tcc att atc tgg agg ccc tcg ttc tct gaa     2129
 Gly His Ser Ser Gln Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu
 665                 670                 675                 680

 ggc acg gac ctt ttc agc ttt ttc cgg gac gtg ggc ctg aaa ata ctg     2177
 Gly Thr Asp Leu Phe Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu
                 685                 690                 695

 tcc aat gcc aaa atc aag aag cca gta gat tgc agt cac aga tct cca     2225
 Ser Asn Ala Lys Ile Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro
             700                 705                 710

 gaa tac agc act gct atg ggt gca ggc ggt ggt cat cca gag gct ttt     2273
 Glu Tyr Ser Thr Ala Met Gly Ala Gly Gly Gly His Pro Glu Ala Phe
         715                 720                 725

 gag tca tca act cct tta cat caa gca gag gat tct cag gtc cgc cag     2321
 Glu Ser Ser Thr Pro Leu His Gln Ala Glu Asp Ser Gln Val Arg Gln
     730                 735                 740

 tac ttc cca gag acc tgg ctc tgg gat ctg ttt cct att ggt aac tcg     2369
 Tyr Phe Pro Glu Thr Trp Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser
 745                 750                 755                 760

 ggg aag gag gcg gtc cac gtc aca gtt cct gac gcc atc acc gag tgg     2417
 Gly Lys Glu Ala Val His Val Thr Val Pro Asp Ala Ile Thr Glu Trp
                 765                 770                 775

 aag gcg atg agt ttc tgc act tcc cag tca aga ggc ttc ggg ctt tca     2465
 Lys Ala Met Ser Phe Cys Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser
             780                 785                 790

 ccc act gtt gga cta act gct ttc aag cca ttc ttt gtt gac ctg act     2513
 Pro Thr Val Gly Leu Thr Ala Phe Lys Pro Phe Phe Val Asp Leu Thr
         795                 800                 805

 ctc cct tac tca gta gtc cgt ggg gaa tcc ttt cgt ctt act gcc acc     2561
 Leu Pro Tyr Ser Val Val Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr
     810                 815                 820

 atc ttc aat tac cta aag gat tgc atc agg gtg aga gct ggg gat aca     2609
 Ile Phe Asn Tyr Leu Lys Asp Cys Ile Arg Val Arg Ala Gly Asp Thr
 825                 830                 835                 840

 gga atc agg tgt cag ccc tgg aat cac acc tcc ccc ata act ttg tct     2657
 Gly Ile Arg Cys Gln Pro Trp Asn His Thr Ser Pro Ile Thr Leu Ser
                 845                 850                 855

 cta aat tgg aag cat ccc aat ttt ccc tgg gaa aga gag gag atg tcg     2705
 Leu Asn Trp Lys His Pro Asn Phe Pro Trp Glu Arg Glu Glu Met Ser
             860                 865                 870

 gcg tct cag ccc cca ggt ttc ccc agg cct cta tgc act acc tcc ttt     2753
 Ala Ser Gln Pro Pro Gly Phe Pro Arg Pro Leu Cys Thr Thr Ser Phe
         875                 880                 885

 gtt tgt acc ctt tgt ctc tta aac atc ctc cgt agg ttc aga ctg acc     2801
 Val Cys Thr Leu Cys Leu Leu Asn Ile Leu Arg Arg Phe Arg Leu Thr
     890                 895                 900

 tgg cta aat cgc atg agt acc agc tag aatca tgggcagatt ctcagacctc     2853
 Trp Leu Asn Arg Met Ser Thr Ser 
 905                 910

 cagttgtctc tgtgctgatg aagcaaaaac ccaccactgg aacatcacag ctgtcaaatt   2913

 gggtaagaga gggaagtggt agacgggcga ggaaagccag cagcagaaga ccagtgactg   2973

 agcactcagt cttttcctct gccacatctg ctttgcttcc tcctccattt tccactattt   3033

 ttctccctcc taaggctgtt ataagtcaat acacaaacac tctttgatag gtgaccaaac   3093

 aaatttgttc aaaccggaat attttgagtg tgaaagggag agcttttaat atttatagct   3153

 ggacaaggaa tacatggtca tgtaactaat caaggactta ctataagagt ccctgggcca   3213

 ggcactattc taactgcttt acatatatta actcattaaa ttgattgact aattaatttt   3273

 tattttattt atttattttt gagaggagaa tcgcttgaac ctgggaggtg gaggttgcag   3333

 tgggctgaga tcacgccatt gcactccagc ctgggcgaca gagtgagact ctgtctcaaa   3393

 aaaaaaaaaa aa                                                       3405




      <210> 396
      <211> 3820
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(1757)

      <400> 396
 acgaccagcg gtggcaacgc cgcgtactcc gcggcctgac cctggaaaaa tctgtctcac     60

 ccacaaag atg tgg gct cag ctc ctt cta gga atg ttg gcc cta tca cca     110
          Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro
            1               5                  10

 gcc att gca gaa gaa ctt cca aac tac ctg gtg aca tta cca gcc cgg      158
 Ala Ile Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg
  15                  20                  25                  30

 cta aat ttc ccc tcc gtt cag aag gtt tgt ttg gac ctg agc cct ggg      206
 Leu Asn Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly
                  35                  40                  45

 tac agt gat gtt aaa ttc acg gtt act ctg gag acc aag gac aag acc      254
 Tyr Ser Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr
              50                  55                  60

 cag aag ttg cta gaa tac tct gga ctg aag aag agg cac tta cat tgt      302
 Gln Lys Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys
          65                  70                  75

 atc tcc ttt ctt gta cca cct cct gct ggt ggc aca gaa gaa gtg gcc      350
 Ile Ser Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala
      80                  85                  90

 aca atc cgg gtg tcg gga gtt gga aat aac atc agc ttt gag gag aag      398
 Thr Ile Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys
  95                 100                 105                 110

 aaa aag gtt cta att cag agg cag ggg aac ggc acc ttt gta cag act      446
 Lys Lys Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr
                 115                 120                 125

 gac aaa cct ctc tac acc cca ggg cag caa gtg tat ttc cgc att gtc      494
 Asp Lys Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val
             130                 135                 140

 acc atg gat agc aac ttc gtt cca gtg aat gac aag tac tcc atg gtg      542
 Thr Met Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val
         145                 150                 155

 gaa cta cag gat cca aat agc aac agg att gca cag tgg ctg gaa gtg      590
 Glu Leu Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val
     160                 165                 170

 gta cct gag caa ggc att gta gac ctg tcc ttc caa ctg gca cca gag      638
 Val Pro Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu
 175                 180                 185                 190

 gca atg ctg ggc acc tac act gtg gca gtg gct gag ggc aag acc ttt      686
 Ala Met Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe
                 195                 200                 205

 ggt act ttc agt gtg gag gaa tat gtg ctg ccg aag ttt aag gtg gaa      734
 Gly Thr Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu
             210                 215                 220

 gtg gtg gaa ccc aag gag tta tca acg gtg cag gaa tct ttc tta gta      782
 Val Val Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val
         225                 230                 235

 aaa att tgt tgt agg tac acc tat gga aag ccc atg cta ggg gca gtg      830
 Lys Ile Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val
     240                 245                 250

 cag gta tct gtg tgt cag aag gca aat act tac tgg tat cga gag gtg      878
 Gln Val Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val
 255                 260                 265                 270

 gaa cgg gaa cag ctt cct gac aaa tgc agg aac ctc tct gga cag act      926
 Glu Arg Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr
                 275                 280                 285

 gac aaa aca gga tgt ttc tca gca cct gtg gac atg gcc acc ttt gac      974
 Asp Lys Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp
             290                 295                 300

 ctc att gga tat gcg tac agc cat caa atc aat att gtg gct act gtt     1022
 Leu Ile Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val
         305                 310                 315

 gtg gag gaa ggg aca ggt gtg gag gcc aat gcc act cag aat atc tac     1070
 Val Glu Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr
     320                 325                 330

 att tct cca caa atg gga tca atg acc ttt gaa gac acc agc aat ttt     1118
 Ile Ser Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe
 335                 340                 345                 350

 tac cat cca aat ttc ccc ttc agt ggg aag ata aga gtt agg ggc cat     1166
 Tyr His Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His
                 355                 360                 365

 gat gac tcc ttc ctc aag aac cat cta gtg ttt ctg gtg att tat ggc     1214
 Asp Asp Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly
             370                 375                 380

 aca aat gga acc ttc aac cag acc ctg gtt act gat aac aat ggc cta     1262
 Thr Asn Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu
         385                 390                 395

 gct ccc ttt acc ttg gag aca tcc ggt tgg aat ggg aca gac gtt tct     1310
 Ala Pro Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser
     400                 405                 410

 ctg gag gga aag ttt caa atg gaa gac tta gta tat aat ccg gaa caa     1358
 Leu Glu Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln
 415                 420                 425                 430

 gtg cca cgt tac tac caa aat gcc tac ctg cac ctg cga ccc ttc tac     1406
 Val Pro Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr
                 435                 440                 445

 agc aca acc cgc agc ttc ctt ggc atc cac cgg cta aac ggc ccc ttg     1454
 Ser Thr Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu
             450                 455                 460

 aaa tgt ggc cag ccc cag gaa gtg ctg gtg gat tat tac atc gac ccg     1502
 Lys Cys Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro
         465                 470                 475

 gcc gat gca agc cct gac caa gag atc agc ttc tcc tac tat tta ata     1550
 Ala Asp Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile
     480                 485                 490

 ggg aaa gga agt ttg gtg atg gag ggg cag aaa cac ctg aac tct aag     1598
 Gly Lys Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys
 495                 500                 505                 510

 aag aaa gga ctg aaa gcc tcc ttc tct ctc tca ctg acc ttc act tcg     1646
 Lys Lys Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser
                 515                 520                 525

 aga ctg gcc cct gat cct tcc ctg gtg atc tat gcc att ttt ccc agt     1694
 Arg Leu Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser
             530                 535                 540

 gga ggt gtt gta gct gac aaa att cag ttc tca gtc ggg atg tgc ttt     1742
 Gly Gly Val Val Ala Asp Lys Ile Gln Phe Ser Val Gly Met Cys Phe
         545                 550                 555

 gac aat cag agc tag actttacaaa gaaagataag tacaaaagtg aaagaatggg     1797
 Asp Asn Gln Ser 
     560

 ttggatgtca tagctggggc atatttgctg atgacccaaa ttatgttgtt tcccttcctt   1857

 tccaggctga cctgatcccc aagttatacc tttcccttcc ccaggtttcc cttggcttct   1917

 ccccctccca gcagcttcca ggagcagaag tggagctgca ggtgcaggca gctcccggat   1977

 ccctgtgtgc gctccgggcg gtggatgaga gtgtcttact gcttaggcca gacagagagc   2037

 tgagcaaccg ctctgtctat gggatgtttc cattctggta tggtcactac ccctatcaag   2097

 tggctgagta tgatcagtgt ccagtgtctg gcccatggga ctttcctcag cccctcattg   2157

 acccaatgcc ccaagggcat tcgagccagc gttccattat ctggaggccc tcgttctctg   2217

 aaggcacgga ccttttcagc tttttccggg acgtgggcct gaaaatactg tccaatgcca   2277

 aaatcaagaa gccagtagat tgcagtcaca gatctccaga atacagcact gctatgggtg   2337

 caggcggtgg tcatccagag gcttttgagt catcaactcc tttacatcaa gcagaggatt   2397

 ctcaggtccg ccagtacttc ccagagacct ggctctggga tctgtttcct attggtaact   2457

 cggggaagga ggcggtccac gtcacagttc ctgacgccat caccgagtgg aaggcgatga   2517

 gtttctgcac ttcccagtca agaggcttcg ggctttcacc cactgttgga ctaactgctt   2577

 tcaagccatt ctttgttgac ctgactctcc cttactcagt agtccgtggg gaatcctttc   2637

 gtcttactgc caccatcttc aattacctaa aggattgcat cagggtgaga gctggggata   2697

 caggaatcag gtgtcagccc tggaatcaca cctcccccat aactttgtct ctaaattgga   2757

 agcatcccaa ttttccctgg gaaagagagg agatgtcggc gtctcagccc ccaggtttcc   2817

 ccaggcctct atgcactacc tcctttgttt gtaccctttg tctcttaaac atcctccgta   2877

 ggttcagact gacctggcta aatcgcatga gtaccagcta gaatcatggg cagattctca   2937

 gacctccagt tgtctctgtg ctgatgaagc aaaaacccac cactggaaca tcacagctgt   2997

 caaattgggt aagagaggga agtggtagac gggcgaggaa agccagcagc agaagaccag   3057

 tgactgagca ctcagtcttt tcctctgcca catctgcttt gcttcctcct ccattttcca   3117

 ctatttttct ccctcctaag gctgttataa gtcaatacac aaacactctt tgataggtga   3177

 ccaaacaaat ttgttcaaac cggaatattt tgagtgtgaa agggagagct tttaatattt   3237

 atagctggac aaggaataca tggtcatgta actaatcaag gacttactat aagagtccct   3297

 gggccaggca ctattctaac tgctttacat atattaactc attaaattga ttgactaatt   3357

 aatttttatt ttatttattt atttttgaga ggagaatcgc ttgaacctgg gaggtggagg   3417

 ttgcagtggg ctgagatcac gccattgcac tccagcctgg gcgacagagt gagactctgt   3477

 ctcaaaaaaa aaaaaaatta tgaaaaaagt tatgggatta aagaaagtca ggataaaaat   3537

 tttaaaaagc aggccactgt cagcaaagcc tggagaagtg gggccggagc ccgcccccaa   3597

 tcatgtgcct gccacccctt cccagtcatc cctttactct tacagtagca aataagaccc   3657

 ctgtctaatg gggggagaca aatgtgtaga cccttagcca ccttggccag ggctgactcc   3717

 ttaaatttct ggatgatgat gattgttatt taatagccag aggtcatata attggcctct   3777

 ttggaagagg ctcatggctc ccttactctc accaaagcaa ttt                     3820




      <210> 397
      <211> 4883
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4425)

      <400> 397
  atg tgg gct cag ctc ctt cta gga atg ttg gcc cta tca cca gcc att      48
  Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile
    1               5                  10                  15

 gca gaa gaa ctt cca aac tac ctg gtg aca tta cca gcc cgg cta aat       96
 Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn
              20                  25                  30

 ttc ccc tcc gtt cag aag gtt tgt ttg gac ctg agc cct ggg tac agt      144
 Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser
          35                  40                  45

 gat gtt aaa ttc acg gtt act ctg gag acc aag gac aag acc cag aag      192
 Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys
      50                  55                  60

 ttg cta gaa tac tct gga ctg aag aag agg cac tta cat tgt atc tcc      240
 Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser
  65                  70                  75                  80

 ttt ctt gta cca cct cct gct ggt ggc aca gaa gaa gtg gcc aca atc      288
 Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile
                  85                  90                  95

 cgg gtg tcg gga gtt gga aat aac atc agc ttt gag gag aag aaa aag      336
 Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys
             100                 105                 110

 gtt cta att cag agg cag ggg aac ggc acc ttt gta cag act gac aaa      384
 Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys
         115                 120                 125

 cct ctc tac acc cca ggg cag caa gtg tat ttc cgc att gtc acc atg      432
 Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met
     130                 135                 140

 gat agc aac ttc gtt cca gtg aat gac aag tac tcc atg gtg gaa cta      480
 Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu
 145                 150                 155                 160

 cag gat cca aat agc aac agg att gca cag tgg ctg gaa gtg gta cct      528
 Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro
                 165                 170                 175

 gag caa ggc att gta gac ctg tcc ttc caa ctg gca cca gag gca atg      576
 Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met
             180                 185                 190

 ctg ggc acc tac act gtg gca gtg gct gag ggc aag acc ttt ggt act      624
 Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr
         195                 200                 205

 ttc agt gtg gag gaa tat gtg ctg ccg aag ttt aag gtg gaa gtg gtg      672
 Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val
     210                 215                 220

 gaa ccc aag gag tta tca acg gtg cag gaa tct ttc tta gta aaa att      720
 Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile
 225                 230                 235                 240

 tgt tgt agg tac acc tat gga aag ccc atg cta ggg gca gtg cag gta      768
 Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val
                 245                 250                 255

 tct gtg tgt cag aag gca aat act tac tgg tat cga gag gtg gaa cgg      816
 Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg
             260                 265                 270

 gaa cag ctt cct gac aaa tgc agg aac ctc tct gga cag act gac aaa      864
 Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys
         275                 280                 285

 aca gga tgt ttc tca gca cct gtg gac atg gcc acc ttt gac ctc att      912
 Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile
     290                 295                 300

 gga tat gcg tac agc cat caa atc aat att gtg gct act gtt gtg gag      960
 Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu
 305                 310                 315                 320

 gaa ggg aca ggt gtg gag gcc aat gcc act cag aat atc tac att tct     1008
 Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser
                 325                 330                 335

 cca caa atg gga tca atg acc ttt gaa gac acc agc aat ttt tac cat     1056
 Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His
             340                 345                 350

 cca aat ttc ccc ttc agt ggg aag ata aga gtt agg ggc cat gat gac     1104
 Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp
         355                 360                 365

 tcc ttc ctc aag aac cat cta gtg ttt ctg gtg att tat ggc aca aat     1152
 Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn
     370                 375                 380

 gga acc ttc aac cag acc ctg gtt act gat aac aat ggc cta gct ccc     1200
 Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro
 385                 390                 395                 400

 ttt acc ttg gag aca tcc ggt tgg aat ggg aca gac gtt tct ctg gag     1248
 Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu
                 405                 410                 415

 gga aag ttt caa atg gaa gac tta gta tat aat ccg gaa caa gtg cca     1296
 Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro
             420                 425                 430

 cgt tac tac caa aat gcc tac ctg cac ctg cga ccc ttc tac agc aca     1344
 Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr
         435                 440                 445

 acc cgc agc ttc ctt ggc atc cac cgg cta aac ggc ccc ttg aaa tgt     1392
 Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys
     450                 455                 460

 ggc cag ccc cag gaa gtg ctg gtg gat tat tac atc gac ccg gcc gat     1440
 Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp
 465                 470                 475                 480

 gca agc cct gac caa gag atc agc ttc tcc tac tat tta ata ggg aaa     1488
 Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys
                 485                 490                 495

 gga agt ttg gtg atg gag ggg cag aaa cac ctg aac tct aag aag aaa     1536
 Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys
             500                 505                 510

 gga ctg aaa gcc tcc ttc tct ctc tca ctg acc ttc act tcg aga ctg     1584
 Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu
         515                 520                 525

 gcc cct gat cct tcc ctg gtg atc tat gcc att ttt ccc agt gga ggt     1632
 Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly
     530                 535                 540

 gtt gta gct gac aaa att cag ttc tca gtc ggg atg tgc ttt gac aat     1680
 Val Val Ala Asp Lys Ile Gln Phe Ser Val Gly Met Cys Phe Asp Asn
 545                 550                 555                 560

 cag gtt tcc ctt ggc ttc tcc ccc tcc cag cag ctt cca gga gca gaa     1728
 Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu
                 565                 570                 575

 gtg gag ctg cag ctg cag gca gct ccc gga tcc ctg tgt gcg ctc cgg     1776
 Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg
             580                 585                 590

 gcg gtg gat gag agt gtc tta ctg ctt agg cca gac aga gag ctg agc     1824
 Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser
         595                 600                 605

 aac cgc tct gtc tat ggg atg ttt cca ttc tgg tat ggt cac tac ccc     1872
 Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro
     610                 615                 620

 tat caa gtg gct gag tat gat cag tgt cca gtg tct ggc cca tgg gac     1920
 Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp
 625                 630                 635                 640

 ttt cct cag ccc ctc att gac cca atg ccc caa ggg cat tcg agc cag     1968
 Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln
                 645                 650                 655

 cgt tcc att atc tgg agg ccc tcg ttc tct gaa ggc acg gac ctt ttc     2016
 Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe
             660                 665                 670

 agc ttt ttc cgg gac gtg ggc ctg aaa ata ctg tcc aat gcc aaa atc     2064
 Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile
         675                 680                 685

 aag aag cca gta gat tgc agt cac aga tct cca gaa tac agc act gct     2112
 Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala
     690                 695                 700

 atg ggt ggc ggt ggt cat cca gag gct ttt gag tca tca act cct tta     2160
 Met Gly Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro Leu
 705                 710                 715                 720

 cat caa gca gag gat tct cag gtc cgc cag tac ttc cca gag acc tgg     2208
 His Gln Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr Trp
                 725                 730                 735

 ctc tgg gat ctg ttt cct att ggt aac tcg ggg aag gag gcg gtc cac     2256
 Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val His
             740                 745                 750

 gtc aca gtt cct gac gcc atc acc gag tgg aag gcg atg agt ttc tgc     2304
 Val Thr Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe Cys
         755                 760                 765

 act tcc cag tca aga ggc ttc ggg ctt tca ccc act gtt gga cta act     2352
 Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu Thr
     770                 775                 780

 gct ttc aag ccg ttc ttt gtt gac ctg act ctc cct tac tca gta gtc     2400
 Ala Phe Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val Val
 785                 790                 795                 800

 cgt ggg gaa tcc ttt cgt ctt act gcc acc atc ttc aat tac cta aag     2448
 Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu Lys
                 805                 810                 815

 gat tgc atc agg gtt cag act gac ctg gct aaa tcg cat gag tac cag     2496
 Asp Cys Ile Arg Val Gln Thr Asp Leu Ala Lys Ser His Glu Tyr Gln
             820                 825                 830

 cta gaa tca tgg gca gat tct cag acc tcc agt tgt ctc tgt gct gat     2544
 Leu Glu Ser Trp Ala Asp Ser Gln Thr Ser Ser Cys Leu Cys Ala Asp
         835                 840                 845

 gac gca aaa acc cac cac tgg aac atc aca gct gtc aaa ttg ggt cac     2592
 Asp Ala Lys Thr His His Trp Asn Ile Thr Ala Val Lys Leu Gly His
     850                 855                 860

 att aac ttt act att agt aca aag att ctg gac agc aat gaa cca tgt     2640
 Ile Asn Phe Thr Ile Ser Thr Lys Ile Leu Asp Ser Asn Glu Pro Cys
 865                 870                 875                 880

 ggg ggc cag aag ggg ttt gtt ccc caa aag ggc cga agt gac acg ctc     2688
 Gly Gly Gln Lys Gly Phe Val Pro Gln Lys Gly Arg Ser Asp Thr Leu
                 885                 890                 895

 atc aag cca gtt ctc gtc aaa cct gag gga gtc ctg gtg gag aag aca     2736
 Ile Lys Pro Val Leu Val Lys Pro Glu Gly Val Leu Val Glu Lys Thr
             900                 905                 910

 cac agc tca ttg ctg tgc cca aaa gga aag gtg gca tct gaa tct gtc     2784
 His Ser Ser Leu Leu Cys Pro Lys Gly Lys Val Ala Ser Glu Ser Val
         915                 920                 925

 tcc ctg gag ctc cca gtg gac att gtt cct gac tcg acc aag gct tat     2832
 Ser Leu Glu Leu Pro Val Asp Ile Val Pro Asp Ser Thr Lys Ala Tyr
     930                 935                 940

 gtt acg gtt ctg ggt aag cag tta gag att ctt gac tca gaa agg aaa     2880
 Val Thr Val Leu Gly Lys Gln Leu Glu Ile Leu Asp Ser Glu Arg Lys
 945                 950                 955                 960

 agg cga atg gag gct gca aag gtg tgg aga gac att atg ggc aca gcc     2928
 Arg Arg Met Glu Ala Ala Lys Val Trp Arg Asp Ile Met Gly Thr Ala
                 965                 970                 975

 ctg cag aac ctg gat ggt ctg gtg cag atg ccc agt ggc tgt ggc gag     2976
 Leu Gln Asn Leu Asp Gly Leu Val Gln Met Pro Ser Gly Cys Gly Glu
             980                 985                 990

 cag aac atg gtc ttg ttt gct ccc atc atc tat gtc ttg cag tac ctg     3024
 Gln Asn Met Val Leu Phe Ala Pro Ile Ile Tyr Val Leu Gln Tyr Leu
         995                1000                1005

 gag aag gca ggg ctg ctg acg gag gag atc agg tct cgg gca gtg ggt     3072
 Glu Lys Ala Gly Leu Leu Thr Glu Glu Ile Arg Ser Arg Ala Val Gly
    1010                1015                1020

 ttc ctg gaa ata ggg tac cag aag gag ctg atg tac aaa cac agc aat     3120
 Phe Leu Glu Ile Gly Tyr Gln Lys Glu Leu Met Tyr Lys His Ser Asn
1025                1030                1035                1040

 ggc tca tac agt gcc ttt ggg gag cga gat gga aat gga aac aca tgg     3168
 Gly Ser Tyr Ser Ala Phe Gly Glu Arg Asp Gly Asn Gly Asn Thr Trp
                1045                1050                1055

 ctg aca gcg ttt gtc aca aaa tgc ttt ggc caa gct cag aaa ttc atc     3216
 Leu Thr Ala Phe Val Thr Lys Cys Phe Gly Gln Ala Gln Lys Phe Ile
            1060                1065                1070

 ttc att gat ccc aag aac atc cag gat gct ctc aag tgg atg gca gga     3264
 Phe Ile Asp Pro Lys Asn Ile Gln Asp Ala Leu Lys Trp Met Ala Gly
        1075                1080                1085

 aac cag ctc ccc agt ggc tgc tat gcc aac gtg gga aat ctc ctt cac     3312
 Asn Gln Leu Pro Ser Gly Cys Tyr Ala Asn Val Gly Asn Leu Leu His
    1090                1095                1100

 aca gct atg aag ggt ggt gtt gat gat gag gtc tcc ttg act gcg tat     3360
 Thr Ala Met Lys Gly Gly Val Asp Asp Glu Val Ser Leu Thr Ala Tyr
1105                1110                1115                1120

 gtc aca gct gca ttg ctg gag atg gga aag gat gta gat gac cca atg     3408
 Val Thr Ala Ala Leu Leu Glu Met Gly Lys Asp Val Asp Asp Pro Met
                1125                1130                1135

 gtg agt cag ggt cta cgg tgt ctc aag aat tcg gcc acc tcc acg acc     3456
 Val Ser Gln Gly Leu Arg Cys Leu Lys Asn Ser Ala Thr Ser Thr Thr
            1140                1145                1150

 aac ctc tac aca cag gcc ctg ttg gct tac att ttc tcc ctg gct ggg     3504
 Asn Leu Tyr Thr Gln Ala Leu Leu Ala Tyr Ile Phe Ser Leu Ala Gly
        1155                1160                1165

 gaa atg gac atc aga aac att ctc ctt aaa cag tta gat caa cag gct     3552
 Glu Met Asp Ile Arg Asn Ile Leu Leu Lys Gln Leu Asp Gln Gln Ala
    1170                1175                1180

 atc atc tca gga gaa tcc att tac tgg agc cag aaa cct act cca tca     3600
 Ile Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser
1185                1190                1195                1200

 tcg aac gcc agc cct tgg tct gag cct gcg gct gta gat gtg gaa ctc     3648
 Ser Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu
                1205                1210                1215

 aca gca tat gca ttg ttg gcc cag ctt acc aag ccc agc ctg act caa     3696
 Thr Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln
            1220                1225                1230

 aag gag ata gcg aag gcc act agc ata gtg gct tgg ttg gcc aag caa     3744
 Lys Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln
        1235                1240                1245

 cac aat gca tat ggg ggc ttc tct tct act cag gat act gta gtt gct     3792
 His Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala
    1250                1255                1260

 ctc caa gct ctt gcc aaa tat gcc act acc gcc tac atg cca tct gag     3840
 Leu Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Met Pro Ser Glu
1265                1270                1275                1280

 gag atc aac ctg gtt gta aaa tcc act gag aat ttc cag cgc aca ttc     3888
 Glu Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe
                1285                1290                1295

 aac ata cag tca gtt aac aga ttg gta ttt cag cag gat acc ctg ccc     3936
 Asn Ile Gln Ser Val Asn Arg Leu Val Phe Gln Gln Asp Thr Leu Pro
            1300                1305                1310

 aat gtc cct gga atg tac acg ttg gag gcc tca ggc cag ggc tgt gtc     3984
 Asn Val Pro Gly Met Tyr Thr Leu Glu Ala Ser Gly Gln Gly Cys Val
        1315                1320                1325

 tat gtg cag acg gtg ttg aga tac aat att ctc cct ccc aca aat atg     4032
 Tyr Val Gln Thr Val Leu Arg Tyr Asn Ile Leu Pro Pro Thr Asn Met
    1330                1335                1340

 aag acc ttt agt ctt agt gtg gaa ata gga aaa gct aga tgt gag caa     4080
 Lys Thr Phe Ser Leu Ser Val Glu Ile Gly Lys Ala Arg Cys Glu Gln
1345                1350                1355                1360

 ccg act tca cct cga tcc ttg act ctc act att cac acc agt tat gtg     4128
 Pro Thr Ser Pro Arg Ser Leu Thr Leu Thr Ile His Thr Ser Tyr Val
                1365                1370                1375

 ggg agc cgt agc tct tcc aat atg gct att gtg gaa gtg aag atg cta     4176
 Gly Ser Arg Ser Ser Ser Asn Met Ala Ile Val Glu Val Lys Met Leu
            1380                1385                1390

 tct ggg ttc agt ccc atg gag ggc acc aat cag tta ctt ctc cag caa     4224
 Ser Gly Phe Ser Pro Met Glu Gly Thr Asn Gln Leu Leu Leu Gln Gln
        1395                1400                1405

 ccc ctg gtg aag aag gtt gaa ttt gga act gac aca ctt aac att tac     4272
 Pro Leu Val Lys Lys Val Glu Phe Gly Thr Asp Thr Leu Asn Ile Tyr
    1410                1415                1420

 ttg gat gag ctc att aag aac act cag act tac acc ttc acc atc agc     4320
 Leu Asp Glu Leu Ile Lys Asn Thr Gln Thr Tyr Thr Phe Thr Ile Ser
1425                1430                1435                1440

 caa agt gtg ctg gtc acc aac ttg aaa cca gca acc atc aag gtc tat     4368
 Gln Ser Val Leu Val Thr Asn Leu Lys Pro Ala Thr Ile Lys Val Tyr
                1445                1450                1455

 gac tac tac cta cca gat gaa cag gca aca att cag tat tct gat ccc     4416
 Asp Tyr Tyr Leu Pro Asp Glu Gln Ala Thr Ile Gln Tyr Ser Asp Pro
            1460                1465                1470

 tgt gaa tga ggatagg agctggaaac tcaattagtc ctctgtgaca ttactggagg     4472
 Cys Glu 


 gtggaacatt cttctgtcgc ttgaagcaga actcattcaa tcaaataatt taatttctct   4532

 gactagtata tgggtaacaa atgaatatgt ctgaacctca gctataatac tttctactac   4592

 ctttgcaagg agatgggata ggaacaatca ctcagaggag gcgttgcatg gacagggtca   4652

 taggggggaa gacacggtgg tttaggctgt ttcatttagc ccttcagggg gctctccaga   4712

 gaggagacgg tggtagaggg tgaactacag cacgataaga atgtcttcct taggccggat   4772

 gcggtggctc acgcctgtta atcccagcac ttcggattgg aacgtgggcc ggatcccttg   4832

 acggtcaccg agttcaagaa ccgcctgcca ctggtaaacc gtttttctaa a            4883




      <210> 398
      <211> 3451
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(2878)

      <400> 398
 ccaccaccta acctggtggt tacagaagga ggaacacagt cctcctgtgt tccaggtgcc     60

 aggaggtgac tgactatagc atcagtcatc actgcacacc ctacctggaa ttagtatata    120

 aagctacgcg gagcgatctc tgcccctgac cctggaaaaa tctgtctcac ccacaaag      178                                                                 
 atg tgg gct cag ctc ctt cta gga atg ttg gcc cta tca cca gcc att      226
 Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile
   1               5                  10                  15

 gca gaa gaa ctt cca aac tac ctg gtg aca tta cca gcc cgg cta aat      274
 Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn
              20                  25                  30

 ttc ccc tcc gtt cag aag gtt tgt ttg gac ctg agc cct ggg tac agt      322
 Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser
          35                  40                  45

 gat gtt aaa ttc acg gtt act ctg gag acc aag gac aag acc cag aag      370
 Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys
      50                  55                  60

 ttg cta gaa tac tct gga ctg aag aag agg cac tta cat tgt atc tcc      418
 Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser
  65                  70                  75                  80

 ttt ctt gta cca cct cct gct ggt ggc aca gaa gaa gtg gcc aca atc      466
 Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile
                  85                  90                  95

 cgg gtg tcg gga gtt gga aat aac atc agc ttt gag gag aag aaa aag      514
 Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys
             100                 105                 110

 gtt cta att cag agg cag ggg aac ggc acc ttt gta cag act gac aaa      562
 Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys
         115                 120                 125

 cct ctc tac acc cca ggg cag caa gtg tat ttc cgc att gtc acc atg      610
 Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met
     130                 135                 140

 gat agc aac ttc gtt cca gtg aat gac aag tac tcc atg gtg gaa cta      658
 Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu
 145                 150                 155                 160

 cag gat cca aat agc aac agg att gca cag tgg ctg gaa gtg gta cct      706
 Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro
                 165                 170                 175

 gag caa ggc att gta gac ctg tcc ttc caa ctg gca cca gag gca atg      754
 Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met
             180                 185                 190

 ctg ggc acc tac act gtg gca gtg gct gag ggc aag acc ttt ggt act      802
 Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr
         195                 200                 205

 ttc agt gtg gag gaa tat gtg ctg ccg aag ttt aag gtg gaa gtg gtg      850
 Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val
     210                 215                 220

 gaa ccc aag gag tta tca acg gtg cag gaa tct ttc tta gta aaa att      898
 Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile
 225                 230                 235                 240

 tgt tgt agg tac acc tat gga aag ccc atg cta ggg gca gtg cag gta      946
 Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val
                 245                 250                 255

 tct gtg tgt cag aag gca aat act tac tgg tat cga gag gtg gaa cgg      994
 Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg
             260                 265                 270

 gaa cag ctt cct gac aaa tgc agg aac ctc tct gga cag act gac aaa     1042
 Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys
         275                 280                 285

 aca gga tgt ttc tca gca cct gtg gac atg gcc acc ttt gac ctc att     1090
 Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile
     290                 295                 300

 gga tat gcg tac agc cat caa atc aat att gtg gct act gtt gtg gag     1138
 Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu
 305                 310                 315                 320

 gaa ggg aca ggt gtg gag gcc aat gcc act cag aat atc tac att tct     1186
 Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser
                 325                 330                 335

 cca caa atg gga tca atg acc ttt gaa gac acc agc aat ttt tac cat     1234
 Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His
             340                 345                 350

 cca aat ttc ccc ttc agt ggg aag ata aga gtt agg ggc cat gat gac     1282
 Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp
         355                 360                 365

 tcc ttc ctc aag aac cat cta gtg ttt ctg gtg att tat ggc aca aat     1330
 Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn
     370                 375                 380

 gga acc ttc aac cag acc ctg gtt act gat aac aat ggc cta gct ccc     1378
 Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro
 385                 390                 395                 400

 ttt acc ttg gag aca tcc ggt tgg aat ggg aca gac gtt tct ctg gag     1426
 Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu
                 405                 410                 415

 gga aag ttt caa atg gaa gac tta gta tat aat ccg gaa caa gtg cca     1474
 Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro
             420                 425                 430

 cgt tac tac caa aat gcc tac ctg cac ctg cga ccc ttc tac agc aca     1522
 Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr
         435                 440                 445

 acc cgc agc ttc ctt ggc atc cac cgg cta aac ggc ccc ttg aaa tgt     1570
 Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys
     450                 455                 460

 ggc cag ccc cag gaa gtg ctg gtg gat tat tac atc gac ccg gcc gat     1618
 Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp
 465                 470                 475                 480

 gca agc cct gac caa gag atc agc ttc tcc tac tat tta ata ggg aaa     1666
 Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys
                 485                 490                 495

 gga agt ttg gtg atg gag ggg cag aaa cac ctg aac tct aag aag aaa     1714
 Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys
             500                 505                 510

 gga ctg aaa gcc tcc ttc tct ctc tca ctg acc ttc act tcg aga ctg     1762
 Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu
         515                 520                 525

 gcc cct gat cct tcc ctg gtg atc tat gcc att ttt ccc agt gga ggt     1810
 Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly
     530                 535                 540

 gtt gta gct gac aaa att cag ttc tca gtc gag atg tgc ttt gac aat     1858
 Val Val Ala Asp Lys Ile Gln Phe Ser Val Glu Met Cys Phe Asp Asn
 545                 550                 555                 560

 cag gtt tcc ctt ggc ttc tcc ccc tcc cag cag ctt cca gga gca gaa     1906
 Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu
                 565                 570                 575

 gtg gag ctg cag ctg cag gca gct ccc gga tcc ctg tgt gcg ctc cgg     1954
 Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg
             580                 585                 590

 gcg gtg gat gag agt gtc tta ctg ctt agg cca gac aga gag ctg agc     2002
 Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser
         595                 600                 605

 aac cgc tct gtc tat ggg atg ttt cca ttc tgg tat ggt cac tac ccc     2050
 Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro
     610                 615                 620

 tat caa gtg gct gag tat gat cag tgt cca gtg tct ggc cca tgg gac     2098
 Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp
 625                 630                 635                 640

 ttt cct cag ccc ctc att gac cca atg ccc caa ggg cat tcg agc cag     2146
 Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln
                 645                 650                 655

 cgt tcc att atc tgg agg ccc tcg ttc tct gaa ggc acg gac ctt ttc     2194
 Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe
             660                 665                 670

 agc ttt ttc cgg gac gtg ggc ctg aaa ata ctg tcc aat gcc aaa atc     2242
 Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile
         675                 680                 685

 aag aag cca gta gat tgc agt cac aga tct cca gaa tac agc act gct     2290
 Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala
     690                 695                 700

 atg ggt gca ggc ggt ggt cat cca gag gct ttt gag tca tca act cct     2338
 Met Gly Ala Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro
 705                 710                 715                 720

 tta cat caa gca gag gat tct cag gtc cgc cag tac ttc cca gag acc     2386
 Leu His Gln Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr
                 725                 730                 735

 tgg ctc tgg gat ctg ttt cct att ggt aac tcg ggg aag gag gcg gtc     2434
 Trp Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val
             740                 745                 750

 cac gtc aca gtt cct gac gcc atc acc gag tgg aag gcg atg agt ttc     2482
 His Val Thr Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe
         755                 760                 765

 tgc act tcc cag tca aga ggc ttc ggg ctt tca ccc act gtt gga cta     2530
 Cys Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu
     770                 775                 780

 act gct ttc aag cca ttc ttt gtt gac ctg act ctc cct tac tca gta     2578
 Thr Ala Phe Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val
 785                 790                 795                 800

 gtc cgt ggg gaa tcc ttt cgt ctt act gcc acc atc ttc aat tac cta     2626
 Val Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu
                 805                 810                 815

 aag gat tgc atc agg gtg aga gct ggg gat aca gga atc agg tgt cag     2674
 Lys Asp Cys Ile Arg Val Arg Ala Gly Asp Thr Gly Ile Arg Cys Gln
             820                 825                 830

 ccc tgg aat cac acc tcc ccc ata act ttg tct cta aat tgg aag cat     2722
 Pro Trp Asn His Thr Ser Pro Ile Thr Leu Ser Leu Asn Trp Lys His
         835                 840                 845

 ccc aat ttt ccc tgg gaa aga gag gag atg tcg gcg tct cag ccc cca     2770
 Pro Asn Phe Pro Trp Glu Arg Glu Glu Met Ser Ala Ser Gln Pro Pro
     850                 855                 860

 ggt ttc ccc agg cct cta tgc act acc tcc ttt gtt tgt acc ctt tgt     2818
 Gly Phe Pro Arg Pro Leu Cys Thr Thr Ser Phe Val Cys Thr Leu Cys
 865                 870                 875                 880

 ctc tta aac atc ctc cgt agg ttc aga ctg acc tgg cta aat cgc atg     2866
 Leu Leu Asn Ile Leu Arg Arg Phe Arg Leu Thr Trp Leu Asn Arg Met
                 885                 890                 895

 agt acc agc tag aat catgggcaga ttctcagacc tccagttgtc tctgtgctga     2921
 Ser Thr Ser 


 tgaagcaaaa acccaccact ggaacatcac agctgtcaaa ttgggtaaga gagggaagtg   2981

 gtagacgggc gaggaaagcc agcagcagaa gaccagtgac tgagcactca gtcttttcct   3041

 ctgccacatc tgctttgctt cctcctccat tttccactat ttttctccct cctaaggctg   3101

 ttataagtca atacacaaac actctttgat aggtgaccaa acaaatttgt tcaaaccgga   3161

 atattttgag tgtgaaaggg agagctttta atatttatag ctggacaagg aatacatggt   3221

 catgtaacta atcaaggact tactataaga gtccctgggc caggcactat tctaactgct   3281

 ttacatatat taactcatta aattgattga ctaattaatt tttattttat ttatttattt   3341

 ttgagaggag aatcgcttga acctgggagg tggaggttgc agtgggctga gatcacgcca   3401

 ttgcactcca gcctgggcga cagagtgaga ctctgtctca aaaaaaaaaa              3451




      <210> 399
      <211> 2275
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (202)..(1917)

      <400> 399
 tttacgtgac actatggaat actcaagcta tgcatcaagc ttggtaccga gctcggatcc     60

 actagtaacg gccgccagtg tgctggaatt cgcccttaag cagtggtaac aacgcagagt    120

 acgcggggga gatcggtggt gctgaagggc agggatctta ttccaccttc tgaagcttct    180

 gtcgaaccag ttgtaaggag a  atg gag aga gca gtg aga gtg gag tcc ggg     231
                          Met Glu Arg Ala Val Arg Val Glu Ser Gly
                            1               5                  10

 gtc ctg gtc ggg gtg gtc tgt ctg ctc ctg gca tgc cct gcc aca gcc      279
 Val Leu Val Gly Val Val Cys Leu Leu Leu Ala Cys Pro Ala Thr Ala
                  15                  20                  25

 act ggg ccc gaa gtt gct cag cct gaa gta gac acc acc ctg ggt cgt      327
 Thr Gly Pro Glu Val Ala Gln Pro Glu Val Asp Thr Thr Leu Gly Arg
              30                  35                  40

 gtg cga ggc cgg cag gtg ggc gtg aag ggc aca gac cgc ctt gtg aat      375
 Val Arg Gly Arg Gln Val Gly Val Lys Gly Thr Asp Arg Leu Val Asn
          45                  50                  55

 gtc ttt ctg ggc att cca ttt gcc cag ccg cca ctg ggc cct gac cgg      423
 Val Phe Leu Gly Ile Pro Phe Ala Gln Pro Pro Leu Gly Pro Asp Arg
      60                  65                  70

 ttc tca gcc cca cac cca gca cag ccc tgg gag ggt gtg cgg gat gcc      471
 Phe Ser Ala Pro His Pro Ala Gln Pro Trp Glu Gly Val Arg Asp Ala
  75                  80                  85                  90

 agc act gcg ccc cca atg tgc cta caa gac gtg gag agc atg aac agc      519
 Ser Thr Ala Pro Pro Met Cys Leu Gln Asp Val Glu Ser Met Asn Ser
                  95                 100                 105

 agc aga ttt gtc ctc aac gga aaa cag cag atc ttc tcc gtt tca gag      567
 Ser Arg Phe Val Leu Asn Gly Lys Gln Gln Ile Phe Ser Val Ser Glu
             110                 115                 120

 gac tgc ctg gtc ctc aat gtc tat agc cca gct gag gtc ccc gca ggg      615
 Asp Cys Leu Val Leu Asn Val Tyr Ser Pro Ala Glu Val Pro Ala Gly
         125                 130                 135

 tcc ggt agg ccg gtc atg gta tgg gtc cat gga ggc gct ctg ata act      663
 Ser Gly Arg Pro Val Met Val Trp Val His Gly Gly Ala Leu Ile Thr
     140                 145                 150

 ggc gct gcc acc tcc tac gat gga tca gct ctg gct gcc tat ggg gat      711
 Gly Ala Ala Thr Ser Tyr Asp Gly Ser Ala Leu Ala Ala Tyr Gly Asp
 155                 160                 165                 170

 gtg gtc gtg gtt aca gtc cag tac cgc ctt ggg gtc ctt ggc ttc ttc      759
 Val Val Val Val Thr Val Gln Tyr Arg Leu Gly Val Leu Gly Phe Phe
                 175                 180                 185

 agc act gga gat gag cat gca cct ggc aac cag ggc ttc cta gat gtg      807
 Ser Thr Gly Asp Glu His Ala Pro Gly Asn Gln Gly Phe Leu Asp Val
             190                 195                 200

 gta gct gct ttg cgc tgg gtg caa gaa aac atc gcc ccc ttc ggg ggt      855
 Val Ala Ala Leu Arg Trp Val Gln Glu Asn Ile Ala Pro Phe Gly Gly
         205                 210                 215

 gac ctc aac tgt gtc act gtc ttt ggt gga tct gcc ggt ggg agc atc      903
 Asp Leu Asn Cys Val Thr Val Phe Gly Gly Ser Ala Gly Gly Ser Ile
     220                 225                 230

 atc tct ggc ctg gtc ctg tcc cca gtg gct gca ggg ctg ttc cac aga      951
 Ile Ser Gly Leu Val Leu Ser Pro Val Ala Ala Gly Leu Phe His Arg
 235                 240                 245                 250

 gcc atc aca cag agt ggg gtc atc acc acc cca ggg atc atc gac tct      999
 Ala Ile Thr Gln Ser Gly Val Ile Thr Thr Pro Gly Ile Ile Asp Ser
                 255                 260                 265

 cac cct tgg ccc cta gct cag aaa atc gca aac acc ttg gcc tgc agc     1047
 His Pro Trp Pro Leu Ala Gln Lys Ile Ala Asn Thr Leu Ala Cys Ser
             270                 275                 280

 tcc agc tcc ccg gct gag atg gtg cag tgc ctt cag cag aaa gaa gga     1095
 Ser Ser Ser Pro Ala Glu Met Val Gln Cys Leu Gln Gln Lys Glu Gly
         285                 290                 295

 gaa gag ctg gtc ctt agc aag aag ctg aaa aat act atc tat cct ctc     1143
 Glu Glu Leu Val Leu Ser Lys Lys Leu Lys Asn Thr Ile Tyr Pro Leu
     300                 305                 310

 acc gtt gat ggc act gtc ttc ccc aaa agc ccc aag gaa ctc ctg aag     1191
 Thr Val Asp Gly Thr Val Phe Pro Lys Ser Pro Lys Glu Leu Leu Lys
 315                 320                 325                 330

 gag aag ccc ttc cac tct gtg ccc ttc ctc atg ggt gtc aac aac cat     1239
 Glu Lys Pro Phe His Ser Val Pro Phe Leu Met Gly Val Asn Asn His
                 335                 340                 345

 gag ttc agc tgg ctc atc ccc agg ggc tgg ggt ctc ctg gat aca atg     1287
 Glu Phe Ser Trp Leu Ile Pro Arg Gly Trp Gly Leu Leu Asp Thr Met
             350                 355                 360

 gag cag atg agc cgg gag gac atg ctg gcc atc tca aca ccc gtc ttg     1335
 Glu Gln Met Ser Arg Glu Asp Met Leu Ala Ile Ser Thr Pro Val Leu
         365                 370                 375

 acc agt ctg gat gtg ccc cct gag atg atg ccc acc gtc ata gat gaa     1383
 Thr Ser Leu Asp Val Pro Pro Glu Met Met Pro Thr Val Ile Asp Glu
     380                 385                 390

 tac cta gga agc aac tcg gac gca caa gcc aaa tgc cag gcg ttc cag     1431
 Tyr Leu Gly Ser Asn Ser Asp Ala Gln Ala Lys Cys Gln Ala Phe Gln
 395                 400                 405                 410

 gaa ttc atg ggt gac gta ttc atc aat gtt ccc acc gtc agt ttt tca     1479
 Glu Phe Met Gly Asp Val Phe Ile Asn Val Pro Thr Val Ser Phe Ser
                 415                 420                 425

 aga tac ctt cga gat tct gga agc cct gtc ttt ttc tat gag ttc cag     1527
 Arg Tyr Leu Arg Asp Ser Gly Ser Pro Val Phe Phe Tyr Glu Phe Gln
             430                 435                 440

 cat cga ccc agt tct ttt gcg aag atc aaa cct gcc tgg gtg aag gct     1575
 His Arg Pro Ser Ser Phe Ala Lys Ile Lys Pro Ala Trp Val Lys Ala
         445                 450                 455

 gat cat ggg gcc gag ggt gct ttt gtg ttc gga ggt ccc ttc ctc atg     1623
 Asp His Gly Ala Glu Gly Ala Phe Val Phe Gly Gly Pro Phe Leu Met
     460                 465                 470

 gac gag agc tcc cgc ctg gcc ttt cca gag gcc aca gag gag gag aag     1671
 Asp Glu Ser Ser Arg Leu Ala Phe Pro Glu Ala Thr Glu Glu Glu Lys
 475                 480                 485                 490

 cag cta agc ctc acc atg atg gcc cag tgg acc cac ttt gcc cgg aca     1719
 Gln Leu Ser Leu Thr Met Met Ala Gln Trp Thr His Phe Ala Arg Thr
                 495                 500                 505

 ggg gac ccc aat agc aag gct ctg cct cct tgg ccc caa ttc aac cag     1767
 Gly Asp Pro Asn Ser Lys Ala Leu Pro Pro Trp Pro Gln Phe Asn Gln
             510                 515                 520

 gcg gaa caa tat ctg gag atc aac cca gtg cca cgg gcc gga cag aag     1815
 Ala Glu Gln Tyr Leu Glu Ile Asn Pro Val Pro Arg Ala Gly Gln Lys
         525                 530                 535

 ttc agg gag gcc tgg atg cag ttc tgg tca gag acg ctc ccc agc aag     1863
 Phe Arg Glu Ala Trp Met Gln Phe Trp Ser Glu Thr Leu Pro Ser Lys
     540                 545                 550

 ata caa cag tgg cac cag aag cag aag aac agg aag gcc cag gag gac     1911
 Ile Gln Gln Trp His Gln Lys Gln Lys Asn Arg Lys Ala Gln Glu Asp
 555                 560                 565                 570

 ctc tga ggccaggcct gaaccttctt ggctggggca aaccactctt caagtggtgg      1967
 Leu 


 cagagtccca gcacggcagc ccgcctctcc ccctgctgag actttaatct ccaccagccc   2027

 ttaaagtgtc ggccgctctg tgactggagt tatgctcttt tgaaatgtca caaggccgcc   2087

 tcccacctct ggggcattgt acaagttctt ccctctccct gaagtgcctt tcctgctttc   2147

 ttcgtggtag gttctagcac attcctctag cttcctggag gactcactcc cccaggaagc   2207

 cttccctgcc ttctctgggc tgtgcggccc cgagtctgcg tccattagag cacagtccac   2267

 ccgaggct                                                            2275




      <210> 400
      <211> 6140
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(5169)

      <400> 400
  atg gcg ggg gcc tgg ctc agg tgg ggg ctc ctg ctc tgg gca ggg ctc      48
  Met Ala Gly Ala Trp Leu Arg Trp Gly Leu Leu Leu Trp Ala Gly Leu
    1               5                  10                  15

 ctc gcg tcc tcg gcg cac ggc cgg ctg cgg agg atc acc tac gtg gtg       96
 Leu Ala Ser Ser Ala His Gly Arg Leu Arg Arg Ile Thr Tyr Val Val
              20                  25                  30

 cac ccg ggc ccc ggc ctg gca gcc ggc gcc ttg ccc ctg agc ggg ccc      144
 His Pro Gly Pro Gly Leu Ala Ala Gly Ala Leu Pro Leu Ser Gly Pro
          35                  40                  45

 ccc gcg tct tcg cgg aca ttc aac gtc gcg ctc aac gcc agg tac agc      192
 Pro Ala Ser Ser Arg Thr Phe Asn Val Ala Leu Asn Ala Arg Tyr Ser
      50                  55                  60

 cgc agc tcg gcg gct gcc ggc gcc ccc agc cgt gcc tcc ccc ggg gtc      240
 Arg Ser Ser Ala Ala Ala Gly Ala Pro Ser Arg Ala Ser Pro Gly Val
  65                  70                  75                  80

 ccc tcg gag agg acc cgg cgc acg agc aag ccg ggc ggc gcg gcc ctg      288
 Pro Ser Glu Arg Thr Arg Arg Thr Ser Lys Pro Gly Gly Ala Ala Leu
                  85                  90                  95

 cag ggg ctc aga ccg ccg ccg ccg ccg ccg ccg gag cct gcg cgt ccc      336
 Gln Gly Leu Arg Pro Pro Pro Pro Pro Pro Pro Glu Pro Ala Arg Pro
             100                 105                 110

 gcg gtc ccc ggc ggg cag ctc cac ccc aat ccc ggc ggc cac ccg gca      384
 Ala Val Pro Gly Gly Gln Leu His Pro Asn Pro Gly Gly His Pro Ala
         115                 120                 125

 gcc gcc ccg ttc acc aaa caa ggc agg caa gtt gtg cgc tcc aag gtg      432
 Ala Ala Pro Phe Thr Lys Gln Gly Arg Gln Val Val Arg Ser Lys Val
     130                 135                 140

 ccg cag gag acc cag agc ggc gga ggc tct agg ctg cag gtt cac cag      480
 Pro Gln Glu Thr Gln Ser Gly Gly Gly Ser Arg Leu Gln Val His Gln
 145                 150                 155                 160

 aag cag cag ctg cag ggg gtc aat gtc tgt gga ggg cgg tgc tgt cat      528
 Lys Gln Gln Leu Gln Gly Val Asn Val Cys Gly Gly Arg Cys Cys His
                 165                 170                 175

 ggc tgg agt aag gcc cct ggc tcc cag agg tgc acc aaa cct agc tgt      576
 Gly Trp Ser Lys Ala Pro Gly Ser Gln Arg Cys Thr Lys Pro Ser Cys
             180                 185                 190

 gtt ccg cca tgt cag aat gga ggg atg tgt ctc cgg cca caa ctc tgt      624
 Val Pro Pro Cys Gln Asn Gly Gly Met Cys Leu Arg Pro Gln Leu Cys
         195                 200                 205

 gtg tgt aaa cca ggg acc aag ggc aaa gcc tgt gaa aca ata gct gcc      672
 Val Cys Lys Pro Gly Thr Lys Gly Lys Ala Cys Glu Thr Ile Ala Ala
     210                 215                 220

 cag gac acc tcg tca cca gtc ttt gga ggg cag agt cct ggg gct gct      720
 Gln Asp Thr Ser Ser Pro Val Phe Gly Gly Gln Ser Pro Gly Ala Ala
 225                 230                 235                 240

 tcc tcg tgg ggc cct cct gag caa gca gca aag cat act tca tct aag      768
 Ser Ser Trp Gly Pro Pro Glu Gln Ala Ala Lys His Thr Ser Ser Lys
                 245                 250                 255

 aag gca gac act cta cca aga gtc agc cct gtg gcc cag atg acc tta      816
 Lys Ala Asp Thr Leu Pro Arg Val Ser Pro Val Ala Gln Met Thr Leu
             260                 265                 270

 acc ctc aag ccg aag cct tca gtg gga ctc ccc cag cag ata cat tct      864
 Thr Leu Lys Pro Lys Pro Ser Val Gly Leu Pro Gln Gln Ile His Ser
         275                 280                 285

 caa gtg act cct ctt tct tcc cag agt gtg gtg att cac cat ggc cag      912
 Gln Val Thr Pro Leu Ser Ser Gln Ser Val Val Ile His His Gly Gln
     290                 295                 300

 acc cag gaa tac gtg ctc aag ccc aag tac ttt cca gcc cag aag ggg      960
 Thr Gln Glu Tyr Val Leu Lys Pro Lys Tyr Phe Pro Ala Gln Lys Gly
 305                 310                 315                 320

 att tca gga gag cag tcc act gaa ggt tct ttc cct tta aga tat gtg     1008
 Ile Ser Gly Glu Gln Ser Thr Glu Gly Ser Phe Pro Leu Arg Tyr Val
                 325                 330                 335

 cag gat caa gtt gcg gca cct ttt cag ctg agt aac cac act ggc cgc     1056
 Gln Asp Gln Val Ala Ala Pro Phe Gln Leu Ser Asn His Thr Gly Arg
             340                 345                 350

 atc aag gtg gtc ttt act ccg agc atc tgt aaa gtg acc tgc acc aag     1104
 Ile Lys Val Val Phe Thr Pro Ser Ile Cys Lys Val Thr Cys Thr Lys
         355                 360                 365

 ggc agc tgt cag aac agc tgt gag aag ggg aac acc acc act ctc att     1152
 Gly Ser Cys Gln Asn Ser Cys Glu Lys Gly Asn Thr Thr Thr Leu Ile
     370                 375                 380

 agt gag aat ggt cat gct gcc gac acc ctg acg gcc acg aac ttc cga     1200
 Ser Glu Asn Gly His Ala Ala Asp Thr Leu Thr Ala Thr Asn Phe Arg
 385                 390                 395                 400

 gtg gta att tgc cat ctt cca tgt atg aat ggt ggc cag tgc agt tca     1248
 Val Val Ile Cys His Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser
                 405                 410                 415

 agg gac aaa tgt cag tgc cct cca aat ttc aca gga aaa ctt tgt cag     1296
 Arg Asp Lys Cys Gln Cys Pro Pro Asn Phe Thr Gly Lys Leu Cys Gln
             420                 425                 430

 atc cca gtc cat ggt gcc agc gtg cct aaa ctt tat cag cat tcc cag     1344
 Ile Pro Val His Gly Ala Ser Val Pro Lys Leu Tyr Gln His Ser Gln
         435                 440                 445

 cag cca ggc aag gcg ttg ggg acg cat gtc atc cat tca aca cat acc     1392
 Gln Pro Gly Lys Ala Leu Gly Thr His Val Ile His Ser Thr His Thr
     450                 455                 460

 ttg cct ctg acc gtg act agc cag caa gga gtc aaa gtg aaa ttt cct     1440
 Leu Pro Leu Thr Val Thr Ser Gln Gln Gly Val Lys Val Lys Phe Pro
 465                 470                 475                 480

 cct aac ata gtc aat atc cat gtg aaa cat cct cct gaa gct tcc gtc     1488
 Pro Asn Ile Val Asn Ile His Val Lys His Pro Pro Glu Ala Ser Val
                 485                 490                 495

 cag ata cat cag gtt tca aga att gat ggc cca aca ggc cag aag aca     1536
 Gln Ile His Gln Val Ser Arg Ile Asp Gly Pro Thr Gly Gln Lys Thr
             500                 505                 510

 aaa gaa gct caa cca ggc caa tcc caa gtc tcg tac caa ggg ctt cct     1584
 Lys Glu Ala Gln Pro Gly Gln Ser Gln Val Ser Tyr Gln Gly Leu Pro
         515                 520                 525

 gtc cag aag acc cag acc ata cat tcc aca tac tcc cac cag cag gtc     1632
 Val Gln Lys Thr Gln Thr Ile His Ser Thr Tyr Ser His Gln Gln Val
     530                 535                 540

 att cct cac gtc tac ccc gtg gct gct aag aca cag ctt ggc cgg tgc     1680
 Ile Pro His Val Tyr Pro Val Ala Ala Lys Thr Gln Leu Gly Arg Cys
 545                 550                 555                 560

 ttc cag gaa acc att ggg tca cag tgt ggc aaa gcg ctc cct ggc ctt     1728
 Phe Gln Glu Thr Ile Gly Ser Gln Cys Gly Lys Ala Leu Pro Gly Leu
                 565                 570                 575

 tca aag caa gag gac tgc tgt gga act gtg ggt acc tcc tgg ggc ttt     1776
 Ser Lys Gln Glu Asp Cys Cys Gly Thr Val Gly Thr Ser Trp Gly Phe
             580                 585                 590

 aac aaa tgc cag aaa tgc ccc aag aaa cca tct tat cat gga tac aac     1824
 Asn Lys Cys Gln Lys Cys Pro Lys Lys Pro Ser Tyr His Gly Tyr Asn
         595                 600                 605

 caa atg atg gaa tgc cta ccg ggt tat aag cgg gtt aac aac acc ttt     1872
 Gln Met Met Glu Cys Leu Pro Gly Tyr Lys Arg Val Asn Asn Thr Phe
     610                 615                 620

 tgc caa gat att aat gaa tgt cag cta caa ggt gta tgc cct aat ggt     1920
 Cys Gln Asp Ile Asn Glu Cys Gln Leu Gln Gly Val Cys Pro Asn Gly
 625                 630                 635                 640

 gag tgt ttg aat acc atg ggc agc tat cga tgt acc tgc aaa ata gga     1968
 Glu Cys Leu Asn Thr Met Gly Ser Tyr Arg Cys Thr Cys Lys Ile Gly
                 645                 650                 655

 ttt ggg ccg gat cct acc ttt tca agt tgt gtt cct gat ccc cct gtg     2016
 Phe Gly Pro Asp Pro Thr Phe Ser Ser Cys Val Pro Asp Pro Pro Val
             660                 665                 670

 atc tcg gaa gag aaa ggg ccc tgt tac cga ctt gtc agt tct gga aga     2064
 Ile Ser Glu Glu Lys Gly Pro Cys Tyr Arg Leu Val Ser Ser Gly Arg
         675                 680                 685

 cag tgt atg cac cct ctg tct gtt cac ctc acc aag cag ctc tgc tgt     2112
 Gln Cys Met His Pro Leu Ser Val His Leu Thr Lys Gln Leu Cys Cys
     690                 695                 700

 tgt agt gtg ggc aag gcc tgg ggc cca cac tgt gag aaa tgt ccc ctt     2160
 Cys Ser Val Gly Lys Ala Trp Gly Pro His Cys Glu Lys Cys Pro Leu
 705                 710                 715                 720

 cca ggc aca gct gct ttt aag gaa atc tgt cct ggt gga atg ggt tat     2208
 Pro Gly Thr Ala Ala Phe Lys Glu Ile Cys Pro Gly Gly Met Gly Tyr
                 725                 730                 735

 acg gtt tct ggc gtt cat aga cgc agg cca atc cat cac cat gta ggt     2256
 Thr Val Ser Gly Val His Arg Arg Arg Pro Ile His His His Val Gly
             740                 745                 750

 aaa gga cct gta ttt gtc aag cca aag aac act caa cct gtt gct aaa     2304
 Lys Gly Pro Val Phe Val Lys Pro Lys Asn Thr Gln Pro Val Ala Lys
         755                 760                 765

 agt act cat cct cca cct ctc cca gcc aag gaa gag cca gtg gag gcc     2352
 Ser Thr His Pro Pro Pro Leu Pro Ala Lys Glu Glu Pro Val Glu Ala
     770                 775                 780

 ctg acc ttc tcc cgg gaa cac ggg cca gga gtg gcg gag cca gaa gtg     2400
 Leu Thr Phe Ser Arg Glu His Gly Pro Gly Val Ala Glu Pro Glu Val
 785                 790                 795                 800

 gca act gca ccc cct gaa aag gaa ata cct tca ttg gat caa gag aaa     2448
 Ala Thr Ala Pro Pro Glu Lys Glu Ile Pro Ser Leu Asp Gln Glu Lys
                 805                 810                 815

 acc aaa ctt gag cct ggt caa ccc cag ctg tct cca ggc att tcc act     2496
 Thr Lys Leu Glu Pro Gly Gln Pro Gln Leu Ser Pro Gly Ile Ser Thr
             820                 825                 830

 att cat ctg cat tca cag ttt cca gta gtg att gaa aaa aca tca cct     2544
 Ile His Leu His Ser Gln Phe Pro Val Val Ile Glu Lys Thr Ser Pro
         835                 840                 845

 cct gtg cct gtt gaa gta gct cct gaa gct tct acg tct agt gcc agc     2592
 Pro Val Pro Val Glu Val Ala Pro Glu Ala Ser Thr Ser Ser Ala Ser
     850                 855                 860

 caa gtg att gct cct act caa gtg aca gaa atc aat gaa tgt act gtg     2640
 Gln Val Ile Ala Pro Thr Gln Val Thr Glu Ile Asn Glu Cys Thr Val
 865                 870                 875                 880

 aac cct gat atc tgt gga gca gga cac tgc att aac cta cca gtg aga     2688
 Asn Pro Asp Ile Cys Gly Ala Gly His Cys Ile Asn Leu Pro Val Arg
                 885                 890                 895

 tat acc tgt ata tgc tac gag ggc tac agg ttc agt gaa caa cag agg     2736
 Tyr Thr Cys Ile Cys Tyr Glu Gly Tyr Arg Phe Ser Glu Gln Gln Arg
             900                 905                 910

 aaa tgt gtg gat att gat gag tgt act cag gtc caa cac ctc tgc tcc     2784
 Lys Cys Val Asp Ile Asp Glu Cys Thr Gln Val Gln His Leu Cys Ser
         915                 920                 925

 cag ggc cgc tgt gaa aac acc gag gga agt ttc ttg tgc att tgc cca     2832
 Gln Gly Arg Cys Glu Asn Thr Glu Gly Ser Phe Leu Cys Ile Cys Pro
     930                 935                 940

 gca gga ttt atg gcc agt gag gag ggt act aac tgc ata gat gtt gac     2880
 Ala Gly Phe Met Ala Ser Glu Glu Gly Thr Asn Cys Ile Asp Val Asp
 945                 950                 955                 960

 gaa tgc ctg agg ccg gac gtc tgt ggg gag ggg cac tgt gtc aat act     2928
 Glu Cys Leu Arg Pro Asp Val Cys Gly Glu Gly His Cys Val Asn Thr
                 965                 970                 975

 gtg ggg gcc ttc cgg tgt gaa tac tgt gac agc ggg tac cgc atg act     2976
 Val Gly Ala Phe Arg Cys Glu Tyr Cys Asp Ser Gly Tyr Arg Met Thr
             980                 985                 990

 cag aga ggc cgt tgt gag gat att gat gaa tgt ttg aat cca agc act     3024
 Gln Arg Gly Arg Cys Glu Asp Ile Asp Glu Cys Leu Asn Pro Ser Thr
         995                1000                1005

 tgt cca gat gag cag tgt gtg aat tct cct gga tct tac cag tgc gtt     3072
 Cys Pro Asp Glu Gln Cys Val Asn Ser Pro Gly Ser Tyr Gln Cys Val
    1010                1015                1020

 ccc tgc aca gaa gga ttc cga ggc tgg aat gga cag tgc ctt gat gtg     3120
 Pro Cys Thr Glu Gly Phe Arg Gly Trp Asn Gly Gln Cys Leu Asp Val
1025                1030                1035                1040

 gac gag tgc ctg gaa cca aac gtc tgc gca aat ggt gat tgt tcc aac     3168
 Asp Glu Cys Leu Glu Pro Asn Val Cys Ala Asn Gly Asp Cys Ser Asn
                1045                1050                1055

 ctt gaa ggc tcc tac atg tgt tca tgc cac aaa ggc tat acc cgg act     3216
 Leu Glu Gly Ser Tyr Met Cys Ser Cys His Lys Gly Tyr Thr Arg Thr
            1060                1065                1070

 ccg gac cac aag cac tgt aga gat att gat gaa tgt cag caa ggg aat     3264
 Pro Asp His Lys His Cys Arg Asp Ile Asp Glu Cys Gln Gln Gly Asn
        1075                1080                1085

 cta tgt gta aac ggg cag tgc aaa aat acc gag ggc tcc ttc agg tgc     3312
 Leu Cys Val Asn Gly Gln Cys Lys Asn Thr Glu Gly Ser Phe Arg Cys
    1090                1095                1100

 acc tgt gga cag ggg tac cag ctg tcg gca gct aaa gac cag tgt gaa     3360
 Thr Cys Gly Gln Gly Tyr Gln Leu Ser Ala Ala Lys Asp Gln Cys Glu
1105                1110                1115                1120

 gac att gat gaa tgc cag cac cgt cat ctc tgt gct cat ggg cag tgc     3408
 Asp Ile Asp Glu Cys Gln His Arg His Leu Cys Ala His Gly Gln Cys
                1125                1130                1135

 agg aac act gag ggc tct ttt caa tgt gtg tgt gac cag ggt tac aga     3456
 Arg Asn Thr Glu Gly Ser Phe Gln Cys Val Cys Asp Gln Gly Tyr Arg
            1140                1145                1150

 gca tct ggg ctt gga gac cac tgt gaa gat atc aat gaa tgc ttg gag     3504
 Ala Ser Gly Leu Gly Asp His Cys Glu Asp Ile Asn Glu Cys Leu Glu
        1155                1160                1165

 gac aag agt gtt tgc cag aga gga gac tgc att aat act gca ggg tcc     3552
 Asp Lys Ser Val Cys Gln Arg Gly Asp Cys Ile Asn Thr Ala Gly Ser
    1170                1175                1180

 tat gat tgt act tgt ccg gat gga ttt cag cta gat gac aat aaa aca     3600
 Tyr Asp Cys Thr Cys Pro Asp Gly Phe Gln Leu Asp Asp Asn Lys Thr
1185                1190                1195                1200

 tgt caa gat att aat gaa tgt gaa cat cca ggg ctc tgt ggt cca caa     3648
 Cys Gln Asp Ile Asn Glu Cys Glu His Pro Gly Leu Cys Gly Pro Gln
                1205                1210                1215

 ggg gag tgc cta aac aca gag ggt tct ttc cat tgt gtc tgc cag cag     3696
 Gly Glu Cys Leu Asn Thr Glu Gly Ser Phe His Cys Val Cys Gln Gln
            1220                1225                1230

 ggt ttc tca atc tct gca gat ggc cgt acg tgt gaa gat att gat gaa     3744
 Gly Phe Ser Ile Ser Ala Asp Gly Arg Thr Cys Glu Asp Ile Asp Glu
        1235                1240                1245

 tgt gta aac aac act gtt tgt gac agt cac ggg ttt tgt gac aat aca     3792
 Cys Val Asn Asn Thr Val Cys Asp Ser His Gly Phe Cys Asp Asn Thr
    1250                1255                1260

 gct ggc tcc ttc cgc tgc ctc tgt tat cag ggc ttt caa gcc cca cag     3840
 Ala Gly Ser Phe Arg Cys Leu Cys Tyr Gln Gly Phe Gln Ala Pro Gln
1265                1270                1275                1280

 gat ggg caa ggg tgt gtg gat gtg aat gaa tgt gaa ctg ctc agt ggg     3888
 Asp Gly Gln Gly Cys Val Asp Val Asn Glu Cys Glu Leu Leu Ser Gly
                1285                1290                1295

 gtg tgt ggt gaa gcc ttc tgt gaa aac gtg gaa ggg tcc ttc ctg tgc     3936
 Val Cys Gly Glu Ala Phe Cys Glu Asn Val Glu Gly Ser Phe Leu Cys
            1300                1305                1310

 gtg tgt gct gat gaa aac caa gag tac agc ccc atg act ggg cag tgc     3984
 Val Cys Ala Asp Glu Asn Gln Glu Tyr Ser Pro Met Thr Gly Gln Cys
        1315                1320                1325

 cgc tcc cgg acc tcc aca gat tta gat gta gat gta gat caa ccc aaa     4032
 Arg Ser Arg Thr Ser Thr Asp Leu Asp Val Asp Val Asp Gln Pro Lys
    1330                1335                1340

 aaa aaa aaa aaa gaa tgc tac tat aat ctc aat gac gcc agt ctc tgt     4080
 Lys Lys Lys Lys Glu Cys Tyr Tyr Asn Leu Asn Asp Ala Ser Leu Cys
1345                1350                1355                1360

 gat aat gtg ttg gcc ccc aat gtc acg aaa caa gaa tgc tgc tgt aca     4128
 Asp Asn Val Leu Ala Pro Asn Val Thr Lys Gln Glu Cys Cys Cys Thr
                1365                1370                1375

 tca ggc gcg gga tgg gga gat aac tgc gaa atc ttc ccc tgc ccg gtc     4176
 Ser Gly Ala Gly Trp Gly Asp Asn Cys Glu Ile Phe Pro Cys Pro Val
            1380                1385                1390

 ttg gga act gct gag ttc act gaa atg tgt ccc aaa ggg aaa ggt ttt     4224
 Leu Gly Thr Ala Glu Phe Thr Glu Met Cys Pro Lys Gly Lys Gly Phe
        1395                1400                1405

 gtg cct gct gga gaa tca tct tct gaa gct ggt ggt gag aac tat aaa     4272
 Val Pro Ala Gly Glu Ser Ser Ser Glu Ala Gly Gly Glu Asn Tyr Lys
    1410                1415                1420

 gat gca gat gaa tgc cta ctt ttt gga caa gaa atc tgc aaa aat ggt     4320
 Asp Ala Asp Glu Cys Leu Leu Phe Gly Gln Glu Ile Cys Lys Asn Gly
1425                1430                1435                1440

 ttc tgt ttg aac act cgg cct ggg tat gaa tgc tac tgt aag caa ggg     4368
 Phe Cys Leu Asn Thr Arg Pro Gly Tyr Glu Cys Tyr Cys Lys Gln Gly
                1445                1450                1455

 acg tac tat gat cct gtg aaa ctg cag tgc ttt gat atg gat gaa tgt     4416
 Thr Tyr Tyr Asp Pro Val Lys Leu Gln Cys Phe Asp Met Asp Glu Cys
            1460                1465                1470

 caa gac ccc agt agt tgt att gat ggc cag tgt gtt aat aca gag ggc     4464
 Gln Asp Pro Ser Ser Cys Ile Asp Gly Gln Cys Val Asn Thr Glu Gly
        1475                1480                1485

 tct tac aac tgc ttc tgt act cac ccc atg gtc ctg gat gcg tca gaa     4512
 Ser Tyr Asn Cys Phe Cys Thr His Pro Met Val Leu Asp Ala Ser Glu
    1490                1495                1500

 aaa aga tgt ata cga ccg gct gag tca aac gaa caa ata gaa gaa act     4560
 Lys Arg Cys Ile Arg Pro Ala Glu Ser Asn Glu Gln Ile Glu Glu Thr
1505                1510                1515                1520

 gat gtc tac caa gat ttg tgc tgg gaa cat ctg agt gat gaa tac gtg     4608
 Asp Val Tyr Gln Asp Leu Cys Trp Glu His Leu Ser Asp Glu Tyr Val
                1525                1530                1535

 tgt agc cgg cct ctt gtg ggc aag cag aca acg tac act gag tgc tgc     4656
 Cys Ser Arg Pro Leu Val Gly Lys Gln Thr Thr Tyr Thr Glu Cys Cys
            1540                1545                1550

 tgt ctg tat gga gag gcc tgg ggc atg cag tgt gcc ctc tgc ccc ctg     4704
 Cys Leu Tyr Gly Glu Ala Trp Gly Met Gln Cys Ala Leu Cys Pro Leu
        1555                1560                1565

 aag gat tca gat gac tat gct cag ctg tgt aac atc ccc gtg acg gga     4752
 Lys Asp Ser Asp Asp Tyr Ala Gln Leu Cys Asn Ile Pro Val Thr Gly
    1570                1575                1580

 cgc cgg cag cca tat gga cgg gac gcc ttg gtt gac ttc agt gaa cag     4800
 Arg Arg Gln Pro Tyr Gly Arg Asp Ala Leu Val Asp Phe Ser Glu Gln
1585                1590                1595                1600

 tat act cca gaa gcc gat ccc tac ttc atc caa gac cgt ttt cta aat     4848
 Tyr Thr Pro Glu Ala Asp Pro Tyr Phe Ile Gln Asp Arg Phe Leu Asn
                1605                1610                1615

 agc ttt gag gag tta cag gct gag gaa tgc ggc atc ctc aat gga tgt     4896
 Ser Phe Glu Glu Leu Gln Ala Glu Glu Cys Gly Ile Leu Asn Gly Cys
            1620                1625                1630

 gaa aat ggt cgc tgt gtg agg gtc cag gaa ggt tac acc tgc gat tgc     4944
 Glu Asn Gly Arg Cys Val Arg Val Gln Glu Gly Tyr Thr Cys Asp Cys
        1635                1640                1645

 ttt gat ggg tat cac ttg gat acg gcc aag atg acc tgt gtc gat gta     4992
 Phe Asp Gly Tyr His Leu Asp Thr Ala Lys Met Thr Cys Val Asp Val
    1650                1655                1660

 aat gaa tgc gat gag ttg aac aac cgg atg tct ctc tgc aag aat gcc     5040
 Asn Glu Cys Asp Glu Leu Asn Asn Arg Met Ser Leu Cys Lys Asn Ala
1665                1670                1675                1680

 aag tgc att aac acc gat ggt tcc tac aag tgt ttg tgt ctg cca ggc     5088
 Lys Cys Ile Asn Thr Asp Gly Ser Tyr Lys Cys Leu Cys Leu Pro Gly
                1685                1690                1695

 tac gtg cct tct gac aag cca aac tac tgc act ccg ttg aat acc gcc     5136
 Tyr Val Pro Ser Asp Lys Pro Asn Tyr Cys Thr Pro Leu Asn Thr Ala
            1700                1705                1710

 ttg aat tta gag aaa gac agt gac ctg gag tga aacagaat ctacataacc     5187
 Leu Asn Leu Glu Lys Asp Ser Asp Leu Glu 
        1715                1720

 taagcccata tactctgcac tgtgtaaagg aaaagggaga aatgtattat acttgagaca   5247

 ttgcacctac cccggaaggc tggaaataca gaaacagcat ggagttgcaa gtcctctgaa   5307

 gacaatgaga ggatttagga tgagcccgat aggtgtggca gaccaaatgg acatttctct   5367

 aaaaaaccag tatatatagt ctgttcatat gtaaaattca atggaagaga ggtggaacag   5427

 tgctgttatt ttaaacagaa ggttgtatta ttatgttgtt ttgttttttt actattgctt   5487

 gattaaattt ggcatttaaa tagtggtgga aatattttat ataattttca ttttttggtt   5547

 gtgcagttcc ttggctactg tttttctttt acttcagttt tttaaaaatc tcaaatgaaa   5607

 aagtcttcga tacaatattg ttaagctgta ttataagtat tgttacacag ggttatgcaa   5667

 ttcccggcct ggagcatttt tgaaattcaa attgtctgtc ctgtggagca ggcagtgatt   5727

 ttgttccaaa actttgtata cacatttgga gaaaagtact ttatattttc agtgttttgt   5787

 ctgattttaa tgtccgttct tagccaagct gctagcaggt gttaattgga tccctttcct   5847

 tcactgaaat ggaagagttt ataagcttac gttagtattg taatatgtaa agtaagccca   5907

 acaaaaattt ttaaaaattt gatgatcccc aatatatcta ccattgtatg ttaaataaat   5967

 caccattttt gtagaaaaaa ttctacctga gagtaattgt caatgagtac atgtgtataa   6027

 gttgtatccc actctcccca cttttatctt ttccagtggt cttctgttaa tgtagtgtct   6087

 tttacaagtt aatcattaaa tttgttagat cttgttaaaa aaaaaaaaaa aaa          6140




      <210> 401
      <211> 2393
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (376)..(876)

      <400> 401
 tgtgggtaag gcgcggcgcg cggccccgag cgcgccaacc ttgccctagc cggagcccgc     60

 tgcggcccag cgcacggccc tcaccccgca tcgcgacccc gcgccccgcc ggccgagcat    120

 gggcgcgcgc gcctcaggcg ggcccctggc ccgggccggg ctcctgctgc tgctgctgct    180

 gctgctgctg ctcgggctgc tggccccggt gcgcgcaggg ggcgcggggc cgcggcggcg    240

 cggagaagaa cagctacccg ccgcacggtc aacaccttct cccagagcgt cagcagcctg    300

 ttcggcgagg acaacgtgcg cgccgctcag aagttcttgg ccaggctgac tgagagattt    360

 gtgctgggag tggat atg ttc gtg gag aca ctg tgg aaa gtc tgg acc gag     411
                  Met Phe Val Glu Thr Leu Trp Lys Val Trp Thr Glu
                    1               5                  10

 ctc ttg gat gtt ctt gga ctt gac gtc tcc aac ctg tcc cag tat ttc      459
 Leu Leu Asp Val Leu Gly Leu Asp Val Ser Asn Leu Ser Gln Tyr Phe
          15                  20                  25

 agc cca gcc tcg gtg tcc agc agc ccg gcc cgc gcg ctc ctg ctg gtc      507
 Ser Pro Ala Ser Val Ser Ser Ser Pro Ala Arg Ala Leu Leu Leu Val
      30                  35                  40

 ggc gtc gtc ctc ctg gcc tac tgg ttc ttg tcc ctg acc ctg ggc ttc      555
 Gly Val Val Leu Leu Ala Tyr Trp Phe Leu Ser Leu Thr Leu Gly Phe
  45                  50                  55                  60

 act ttc agc gtc ctg cac gtg gtg ttc ggc cgc ttc ttc tgg atc gtg      603
 Thr Phe Ser Val Leu His Val Val Phe Gly Arg Phe Phe Trp Ile Val
                  65                  70                  75

 cgg gtc gtc ctg ttt tcc atg tcc tgc gtg tac atc ctg cac aag tac      651
 Arg Val Val Leu Phe Ser Met Ser Cys Val Tyr Ile Leu His Lys Tyr
              80                  85                  90

 gag ggc gag ccg gag aac gcg gtg ctg ccg ctg tgc ttc gtg gtg gcc      699
 Glu Gly Glu Pro Glu Asn Ala Val Leu Pro Leu Cys Phe Val Val Ala
          95                 100                 105

 gtc tac ttc atg acc ggg ccc atg ggc ttc tac tgg cga agc agt ccc      747
 Val Tyr Phe Met Thr Gly Pro Met Gly Phe Tyr Trp Arg Ser Ser Pro
     110                 115                 120

 agc ggc ccc agc aac ccc agc aac ccc agc gtg gag gag aag ctg gag      795
 Ser Gly Pro Ser Asn Pro Ser Asn Pro Ser Val Glu Glu Lys Leu Glu
 125                 130                 135                 140

 cac ctg gag aag cag gtc aga ctg ctc aac atc cgt ctc aac cgg gtg      843
 His Leu Glu Lys Gln Val Arg Leu Leu Asn Ile Arg Leu Asn Arg Val
                 145                 150                 155

 ctc gag agc ctg gac cgc tcc aag gac aag tga aggtcagc cggccgggcg      894
 Leu Glu Ser Leu Asp Arg Ser Lys Asp Lys 
             160                 165

 ggtccacagt taccagcacg ctgtctcaga aaacgaaaac ggaggaaaaa aaccccaaac    954

 cccaaacaat cttaataaac acgactgagc aagaaagtgg cgctgtgtaa ggctatttcc   1014

 acccacccgg cagctcttag gacacattcc cagaagagcg gaaagatcat tgacgtggaa   1074

 ctacacacga agtgtaatta gtgggggaaa aaatattttt taaacaaagg atataaccat   1134

 atttagttgt acagtaagag aaatttatct gtgcatagag cataaagtta attttttcaa   1194

 gcatttaaat acatcttttg taaggttttt taataaaggc agattgagtc aagtttatta   1254

 aaactttaca tggaggggaa gaatatgcta atttgacatt tgagaaaagt ttaaatgcga   1314

 gcgtttgttt tcacagctta gggattggtg ggtgaggtct gtgtgcgtta ttttcatgtt   1374

 cccaaactgt gagctttatt tcatgttatt tttggtggat gttgacttag ttcatgaatg   1434

 ttgtcacttc taaatgtgga cagttgggct gcaggatgca actcaacctc ttttggatcc   1494

 tagagacccc tgccaagccc ccatcagtcc tatttttaaa tgaagacatc gccatttcta   1554

 gaagacctga gattttcttc cctctgtgct tcgatgtatt ttaacctcaa cattttgaaa   1614

 cggaaaatgc aaggaggggc caagaaatgt cctggggatt tgatgccagg aagtacctgg   1674

 taaggattgg agattgctcc agaatctact gcatgtccca atttgcagtt tgctcactag   1734

 ggctatatac aaaagctata cccttgaggg tttttttttt ttcttttgat ttcctcagga   1794

 ccttagaggg aaaacaaaca gtagcagcta atattctcaa gtatattgct gcttagaaag   1854

 atcctcagga acaattagca gcaataagca agcctttgaa aagatctgaa ttctttttcc   1914

 tgaaatattt acgatacaca ggtgcttttt atctgaaatc tgttgtgtcc tccttttagg   1974

 cagtctctgt gggcagagag tgggacttgc gaggtggaca gctgtgggga tcctgggcaa   2034

 gggagtttca gaaggtgtgg ctcaggggct ggtagaaacc cccttttgtt aggacttgtt   2094

 ttttaaaaaa agccctaggc caggcgcagt ggctgatgcc tgtaatccca gcgctttggg   2154

 aggccgagga gtatggatca cctgaggtca ggagttcaag accagcctgg ccaacatggt   2214

 gaaacccccg tctctactaa aaatacaaaa attagtcagg catggtggtg ggtgcctgta   2274

 gtccagctac tcaggaggct gaggcaggag aattgcttga acctgggagg tggaggttgc   2334

 ggtgagccga gatcacgcct ctgcactcca gcctaggcaa cagagcaaga cttcatctt    2393




      <210> 402
      <211> 5802
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (160)..(4473)

      <400> 402
 cccacgcgtc cgagacggtg cagtctccgg gatcgcattc ttctcccggt gcccgctgag     60

 ccgagggcaa gaagagaaca aggaccctct cggcctcagg aatcttctcc ccagagactc    120

 ctaagtgggc acactgcttc tgttgttgct ctcgtaacc   atg act ctg ccg cac     174
                                              Met Thr Leu Pro His
                                                1               5

 agc ttg gga ggt gcg ggg gac ccc cgg ccc ccc cag gcc atg gag gtt      222
 Ser Leu Gly Gly Ala Gly Asp Pro Arg Pro Pro Gln Ala Met Glu Val
                  10                  15                  20

 cac agg ctg gag cac cgg cag gag gag gag cag aag gag gag cgg cag      270
 His Arg Leu Glu His Arg Gln Glu Glu Glu Gln Lys Glu Glu Arg Gln
              25                  30                  35

 cac agc ctg cgc atg ggc tcc tct gtg cgg agg cgg acc ttc cgc agc      318
 His Ser Leu Arg Met Gly Ser Ser Val Arg Arg Arg Thr Phe Arg Ser
          40                  45                  50

 agc gaa gaa gag cat gag ttc agc gcc gcg gac tac gcc ctg gca gca      366
 Ser Glu Glu Glu His Glu Phe Ser Ala Ala Asp Tyr Ala Leu Ala Ala
      55                  60                  65

 gcc ctg gct ctg acg gcc tcc tcc gag ctg tct tgg gaa gcc cag ctg      414
 Ala Leu Ala Leu Thr Ala Ser Ser Glu Leu Ser Trp Glu Ala Gln Leu
  70                  75                  80                  85

 aga cgc cag acc tct gcc gtg gag ctg gag gag cga ggg cag aag cgg      462
 Arg Arg Gln Thr Ser Ala Val Glu Leu Glu Glu Arg Gly Gln Lys Arg
                  90                  95                 100

 gtg ggc ttc ggc aat gac tgg gag agg act gag atc gcc ttc ctg cag      510
 Val Gly Phe Gly Asn Asp Trp Glu Arg Thr Glu Ile Ala Phe Leu Gln
             105                 110                 115

 acc cac cgg ctg ctg cgc cag agg cgg gac tgg aag acg ctg agg cgg      558
 Thr His Arg Leu Leu Arg Gln Arg Arg Asp Trp Lys Thr Leu Arg Arg
         120                 125                 130

 cgg aca gag gag aag gtc cag gag gcc aag gag ctg agg gag ctg tgc      606
 Arg Thr Glu Glu Lys Val Gln Glu Ala Lys Glu Leu Arg Glu Leu Cys
     135                 140                 145

 tac ggc cgc ggg ccc tgg ttc tgg atc cct ctt cgc tcc cac gcc gtc      654
 Tyr Gly Arg Gly Pro Trp Phe Trp Ile Pro Leu Arg Ser His Ala Val
 150                 155                 160                 165

 tgg gag cac acc acg gtc ctg ctg acc tgc act gtc cag gcc tca cca      702
 Trp Glu His Thr Thr Val Leu Leu Thr Cys Thr Val Gln Ala Ser Pro
                 170                 175                 180

 cca ccc cag gtc acc tgg tac aaa aat gac aca cgg att gat ccc cgc      750
 Pro Pro Gln Val Thr Trp Tyr Lys Asn Asp Thr Arg Ile Asp Pro Arg
             185                 190                 195

 ctc ttt cgt gcc gga aaa tac cga atc acc aac aac tac ggg ctg ctg      798
 Leu Phe Arg Ala Gly Lys Tyr Arg Ile Thr Asn Asn Tyr Gly Leu Leu
         200                 205                 210

 tcc ctg gag att agg aga tgc gcc att gag gac tca gca act tac act      846
 Ser Leu Glu Ile Arg Arg Cys Ala Ile Glu Asp Ser Ala Thr Tyr Thr
     215                 220                 225

 gtg cga gtg aag aac gcc cac ggc cag gcc tcc tcc ttc gcc aaa gtc      894
 Val Arg Val Lys Asn Ala His Gly Gln Ala Ser Ser Phe Ala Lys Val
 230                 235                 240                 245

 ctc gtc cgc act tac ctg ggg aag gat gct ggc ttc gat tca gag atc      942
 Leu Val Arg Thr Tyr Leu Gly Lys Asp Ala Gly Phe Asp Ser Glu Ile
                 250                 255                 260

 ttc aaa aga tcg acg ttt ggc ccc agc gtg gaa ttc acc tcg gtg ctg      990
 Phe Lys Arg Ser Thr Phe Gly Pro Ser Val Glu Phe Thr Ser Val Leu
             265                 270                 275

 aag cca gtc ttt gct cgt gag aag gaa ccc ttc tcc ctg tca tgc ttg     1038
 Lys Pro Val Phe Ala Arg Glu Lys Glu Pro Phe Ser Leu Ser Cys Leu
         280                 285                 290

 ttt tcg gaa gat gtg tta gat gct gag agc atc cag tgg ttc cga gat     1086
 Phe Ser Glu Asp Val Leu Asp Ala Glu Ser Ile Gln Trp Phe Arg Asp
     295                 300                 305

 ggg agc cta ctg agg tcc tcg aga cgt cgg aag atc ctc tac aca gac     1134
 Gly Ser Leu Leu Arg Ser Ser Arg Arg Arg Lys Ile Leu Tyr Thr Asp
 310                 315                 320                 325

 cgc cag gca tcc ctg aag gtg tcc tgc acc tac aag gag gac gag ggg     1182
 Arg Gln Ala Ser Leu Lys Val Ser Cys Thr Tyr Lys Glu Asp Glu Gly
                 330                 335                 340

 ctc tac atg gtc cgg gtg ccc tcg ccc ttc gga ccc cgg gaa cag agc     1230
 Leu Tyr Met Val Arg Val Pro Ser Pro Phe Gly Pro Arg Glu Gln Ser
             345                 350                 355

 acc tac gtg ctt gtg aga gat gcc gag gcc gag aac ccc ggg gcc cca     1278
 Thr Tyr Val Leu Val Arg Asp Ala Glu Ala Glu Asn Pro Gly Ala Pro
         360                 365                 370

 ggc tcc cca ctg aac gtc cga tgc ctg gat gtg aac aga gac tgc ctc     1326
 Gly Ser Pro Leu Asn Val Arg Cys Leu Asp Val Asn Arg Asp Cys Leu
     375                 380                 385

 atc ctg act tgg gcc ccg ccc agt gac acc cgg ggc aac ccc atc act     1374
 Ile Leu Thr Trp Ala Pro Pro Ser Asp Thr Arg Gly Asn Pro Ile Thr
 390                 395                 400                 405

 gcc tac acc att gag cgg tgc cag ggc gag tct ggg gaa tgg atc gcc     1422
 Ala Tyr Thr Ile Glu Arg Cys Gln Gly Glu Ser Gly Glu Trp Ile Ala
                 410                 415                 420

 tgc cat gag gcc ccc gga ggg act tgt cgg tgc cca atc caa ggc ctc     1470
 Cys His Glu Ala Pro Gly Gly Thr Cys Arg Cys Pro Ile Gln Gly Leu
             425                 430                 435

 gtc gaa ggt cag agc tat cgg ttc cgg gtg aga gcc atc agc agg gta     1518
 Val Glu Gly Gln Ser Tyr Arg Phe Arg Val Arg Ala Ile Ser Arg Val
         440                 445                 450

 ggc agc agc gtc ccc tcc aag gcc tca gag ttg gtt gtc atg ggt gac     1566
 Gly Ser Ser Val Pro Ser Lys Ala Ser Glu Leu Val Val Met Gly Asp
     455                 460                 465

 cat gat gca gcc cgg agg aag aca gag atc ccc ttt gat ctg gga aac     1614
 His Asp Ala Ala Arg Arg Lys Thr Glu Ile Pro Phe Asp Leu Gly Asn
 470                 475                 480                 485

 aag atc acc atc agc aca gac gct ttt gaa gat act gtg acc atc ccc     1662
 Lys Ile Thr Ile Ser Thr Asp Ala Phe Glu Asp Thr Val Thr Ile Pro
                 490                 495                 500

 tca ccg cca acc aat gtc cat gcc agc gag atc cga gag gcc tat gtg     1710
 Ser Pro Pro Thr Asn Val His Ala Ser Glu Ile Arg Glu Ala Tyr Val
             505                 510                 515

 gtt ctg gcc tgg gag gag ccc agc ccc cgg ggc aga gca cca ctg acg     1758
 Val Leu Ala Trp Glu Glu Pro Ser Pro Arg Gly Arg Ala Pro Leu Thr
         520                 525                 530

 tac tcc ctg gag aag tca gtc ata ggt agt ggc acc tgg gag gcc atc     1806
 Tyr Ser Leu Glu Lys Ser Val Ile Gly Ser Gly Thr Trp Glu Ala Ile
     535                 540                 545

 agc tcg gaa agc cct gtg aga tcc ccg aga ttc gcc gtt ctg gac ctg     1854
 Ser Ser Glu Ser Pro Val Arg Ser Pro Arg Phe Ala Val Leu Asp Leu
 550                 555                 560                 565

 gag aaa aag aag tcg tat gtc ttc aga gtg cga gca atg aac cag tat     1902
 Glu Lys Lys Lys Ser Tyr Val Phe Arg Val Arg Ala Met Asn Gln Tyr
                 570                 575                 580

 ggc ctg agc gat ccc tcg gag ccc agc gaa ccc atc gcc ttg cgg ggc     1950
 Gly Leu Ser Asp Pro Ser Glu Pro Ser Glu Pro Ile Ala Leu Arg Gly
             585                 590                 595

 ccg cca gct acc ctc cct cct cca gct caa gtt caa gct ttc aga gac     1998
 Pro Pro Ala Thr Leu Pro Pro Pro Ala Gln Val Gln Ala Phe Arg Asp
         600                 605                 610

 aca cag acc tct gtc tcc ctg aca tgg gat cct gtg aaa gac cca gag     2046
 Thr Gln Thr Ser Val Ser Leu Thr Trp Asp Pro Val Lys Asp Pro Glu
     615                 620                 625

 ctc ctg ggt tat tac atc tac tcc cgg aag gtg ggg aca tct gag tgg     2094
 Leu Leu Gly Tyr Tyr Ile Tyr Ser Arg Lys Val Gly Thr Ser Glu Trp
 630                 635                 640                 645

 caa aca gtt aac aac aaa ccc atc caa ggc acc agg ttt aca gtt ccc     2142
 Gln Thr Val Asn Asn Lys Pro Ile Gln Gly Thr Arg Phe Thr Val Pro
                 650                 655                 660

 ggg ctg agg acg ggg aag gag tac gag ttt tgt gtc agg tca gtc agc     2190
 Gly Leu Arg Thr Gly Lys Glu Tyr Glu Phe Cys Val Arg Ser Val Ser
             665                 670                 675

 gag gct ggg gta ggc gag agc tca gcc gcc acc gag ccc atc agg gtc     2238
 Glu Ala Gly Val Gly Glu Ser Ser Ala Ala Thr Glu Pro Ile Arg Val
         680                 685                 690

 aag cag gct ctg gct acc ccg tct gcc cca tat ggc ttt gcc ctc ctg     2286
 Lys Gln Ala Leu Ala Thr Pro Ser Ala Pro Tyr Gly Phe Ala Leu Leu
     695                 700                 705

 aac tgc ggg aag aat gaa atg gtc att ggg tgg aaa ccc ccc aag cgt     2334
 Asn Cys Gly Lys Asn Glu Met Val Ile Gly Trp Lys Pro Pro Lys Arg
 710                 715                 720                 725

 cgt gga ggt ggc aag atc ctg ggc tac ttc ctg gac cag cat gac tcg     2382
 Arg Gly Gly Gly Lys Ile Leu Gly Tyr Phe Leu Asp Gln His Asp Ser
                 730                 735                 740

 gaa gag ctg gac tgg cat gcg gtc aat cag cag ccc atc ccc acc cgg     2430
 Glu Glu Leu Asp Trp His Ala Val Asn Gln Gln Pro Ile Pro Thr Arg
             745                 750                 755

 gtc tgc aag gtc agt gac ctt cat gaa ggc cac ttc tat gag ttc cgt     2478
 Val Cys Lys Val Ser Asp Leu His Glu Gly His Phe Tyr Glu Phe Arg
         760                 765                 770

 gcc cgg gct gcc aac tgg gca ggt gtt ggc gag ctg tcg gca ccc agc     2526
 Ala Arg Ala Ala Asn Trp Ala Gly Val Gly Glu Leu Ser Ala Pro Ser
     775                 780                 785

 agc ctg ttt gag tgc aaa gag tgg aca atg ccc cag cca ggc ccc ccg     2574
 Ser Leu Phe Glu Cys Lys Glu Trp Thr Met Pro Gln Pro Gly Pro Pro
 790                 795                 800                 805

 tac gat gta cgg gca tcc gag gtg cgg gct aca tcc ctg gtg ctg cag     2622
 Tyr Asp Val Arg Ala Ser Glu Val Arg Ala Thr Ser Leu Val Leu Gln
                 810                 815                 820

 tgg gaa ccc cca ctg tat atg ggg gct ggg cct gtc aca ggc tat cac     2670
 Trp Glu Pro Pro Leu Tyr Met Gly Ala Gly Pro Val Thr Gly Tyr His
             825                 830                 835

 gtc agt ttc cag gag gaa ggc tct gag cag tgg aag ccg gtc acc cca     2718
 Val Ser Phe Gln Glu Glu Gly Ser Glu Gln Trp Lys Pro Val Thr Pro
         840                 845                 850

 ggc ccc atc tct ggc acc cac ctg agg gtt tcc gac ttg cag cca gga     2766
 Gly Pro Ile Ser Gly Thr His Leu Arg Val Ser Asp Leu Gln Pro Gly
     855                 860                 865

 aag agt tac gtg ttc cag gta cag gcc atg aat tca gct ggt ctg ggg     2814
 Lys Ser Tyr Val Phe Gln Val Gln Ala Met Asn Ser Ala Gly Leu Gly
 870                 875                 880                 885

 caa ccg tcc atg ccc act gat ccc gtg ctc ctg gag gac aag cca ggt     2862
 Gln Pro Ser Met Pro Thr Asp Pro Val Leu Leu Glu Asp Lys Pro Gly
                 890                 895                 900

 gcc cat gag atc gag gtt ggt gtg gat gaa gag ggc ttt atc tat ttg     2910
 Ala His Glu Ile Glu Val Gly Val Asp Glu Glu Gly Phe Ile Tyr Leu
             905                 910                 915

 gct ttt gaa gcc cct gaa gcc ccc gac tcc tca gag ttt cag tgg tcc     2958
 Ala Phe Glu Ala Pro Glu Ala Pro Asp Ser Ser Glu Phe Gln Trp Ser
         920                 925                 930

 aaa gac tac aag ggc cca ctg gac ccc cag agg gtc aag atc gag gat     3006
 Lys Asp Tyr Lys Gly Pro Leu Asp Pro Gln Arg Val Lys Ile Glu Asp
     935                 940                 945

 aaa gtt aac aag tcc aag gtc atc ctg aaa gaa ccc ggc ctc gag gat     3054
 Lys Val Asn Lys Ser Lys Val Ile Leu Lys Glu Pro Gly Leu Glu Asp
 950                 955                 960                 965

 ttg ggc acc tac tca gtc ata gtc act gat gcc gat gaa gac atc tcc     3102
 Leu Gly Thr Tyr Ser Val Ile Val Thr Asp Ala Asp Glu Asp Ile Ser
                 970                 975                 980

 gca agc cac acg cta acc gag gaa gag ctg gag aag ctg aag aag ctg     3150
 Ala Ser His Thr Leu Thr Glu Glu Glu Leu Glu Lys Leu Lys Lys Leu
             985                 990                 995

 agt cat gag atc aga aac cca gtg atc aaa ctg atc tcc ggc tgg aac     3198
 Ser His Glu Ile Arg Asn Pro Val Ile Lys Leu Ile Ser Gly Trp Asn
        1000                1005                1010

 att gac atc ctg gag cga ggg gag gtg cgg ctt tgg ctg gaa gta gaa     3246
 Ile Asp Ile Leu Glu Arg Gly Glu Val Arg Leu Trp Leu Glu Val Glu
    1015                1020                1025

 aag tta tct cca gcc gct gag cta cat cta atc ttc aac aac aag gag     3294
 Lys Leu Ser Pro Ala Ala Glu Leu His Leu Ile Phe Asn Asn Lys Glu
1030                1035                1040                1045

 atc ttc agc tcg ccg aac cgc aaa atc aat ttt gac cga gag aag ggc     3342
 Ile Phe Ser Ser Pro Asn Arg Lys Ile Asn Phe Asp Arg Glu Lys Gly
                1050                1055                1060

 ctg gtg gaa gtg atc atc cag aac ttg tct gag gag gac aaa ggg tcg     3390
 Leu Val Glu Val Ile Ile Gln Asn Leu Ser Glu Glu Asp Lys Gly Ser
            1065                1070                1075

 tac acc gct caa ctc caa gat gga aaa gcc aaa aac cag att acc ttg     3438
 Tyr Thr Ala Gln Leu Gln Asp Gly Lys Ala Lys Asn Gln Ile Thr Leu
        1080                1085                1090

 aca ctg gtg gat gac gat ttt gac aag ctt ctg agg aag gca gat gct     3486
 Thr Leu Val Asp Asp Asp Phe Asp Lys Leu Leu Arg Lys Ala Asp Ala
    1095                1100                1105

 aag aga agg gac tgg aag aga aaa cag ggt ccc tat ttt gag cgg ccg     3534
 Lys Arg Arg Asp Trp Lys Arg Lys Gln Gly Pro Tyr Phe Glu Arg Pro
1110                1115                1120                1125

 ttg cag tgg aag gtc acg gag gac tgc caa gtg cag ctg acg tgc aag     3582
 Leu Gln Trp Lys Val Thr Glu Asp Cys Gln Val Gln Leu Thr Cys Lys
                1130                1135                1140

 gtg acc aac acc aag aag gag act cgc ttt cag tgg ttc ttc cag agg     3630
 Val Thr Asn Thr Lys Lys Glu Thr Arg Phe Gln Trp Phe Phe Gln Arg
            1145                1150                1155

 gca gag atg cca gat ggt cag tat gac cca gag acg gga acg gga ctt     3678
 Ala Glu Met Pro Asp Gly Gln Tyr Asp Pro Glu Thr Gly Thr Gly Leu
        1160                1165                1170

 ctc tgc att gaa gag ttg tcc aaa aag gac aag gga att tac aga gcg     3726
 Leu Cys Ile Glu Glu Leu Ser Lys Lys Asp Lys Gly Ile Tyr Arg Ala
    1175                1180                1185

 atg gtt tct gac gat cga ggg gag gac gac acc ata ttg gac ctc acg     3774
 Met Val Ser Asp Asp Arg Gly Glu Asp Asp Thr Ile Leu Asp Leu Thr
1190                1195                1200                1205

 ggt gac gcc ctg gat gcc atc ttc acc gag ttg ggc agg att ggt gcc     3822
 Gly Asp Ala Leu Asp Ala Ile Phe Thr Glu Leu Gly Arg Ile Gly Ala
                1210                1215                1220

 ctc tct gca act cca ctg aaa atc cag ggg acc gag gaa ggg atc cgg     3870
 Leu Ser Ala Thr Pro Leu Lys Ile Gln Gly Thr Glu Glu Gly Ile Arg
            1225                1230                1235

 atc ttc agc aag gtc aag tac tac aac gtg gag tac atg aaa acc acc     3918
 Ile Phe Ser Lys Val Lys Tyr Tyr Asn Val Glu Tyr Met Lys Thr Thr
        1240                1245                1250

 tgg ttc cac aaa gac aaa cgt ctg gag agt ggt gat cgg ata agg acg     3966
 Trp Phe His Lys Asp Lys Arg Leu Glu Ser Gly Asp Arg Ile Arg Thr
    1255                1260                1265

 ggc acc acc ctg gat gag atc tgg ctt cac atc ctg gac ccc aaa gac     4014
 Gly Thr Thr Leu Asp Glu Ile Trp Leu His Ile Leu Asp Pro Lys Asp
1270                1275                1280                1285

 tca gac aag ggc aaa tac act ctg gaa ata gct gca ggg aag gaa gtc     4062
 Ser Asp Lys Gly Lys Tyr Thr Leu Glu Ile Ala Ala Gly Lys Glu Val
                1290                1295                1300

 cgg cag ctc tca aca gat ctc tca ggg caa gct ttt gag gat gca atg     4110
 Arg Gln Leu Ser Thr Asp Leu Ser Gly Gln Ala Phe Glu Asp Ala Met
            1305                1310                1315

 gct gaa cac cag aga ctg aaa acc ttg gcc atc atc gag aag aat cgt     4158
 Ala Glu His Gln Arg Leu Lys Thr Leu Ala Ile Ile Glu Lys Asn Arg
        1320                1325                1330

 gcc aaa gtg gtg aga ggt ctg ccg gat gtg gcc act atc atg gaa gat     4206
 Ala Lys Val Val Arg Gly Leu Pro Asp Val Ala Thr Ile Met Glu Asp
    1335                1340                1345

 aag acc ctg tgc ttg act tgc atc gtc tca gga gac ccc acc cct gaa     4254
 Lys Thr Leu Cys Leu Thr Cys Ile Val Ser Gly Asp Pro Thr Pro Glu
1350                1355                1360                1365

 atc tct tgg ctg aag aat gac cag cct gtc acc ttc ctt gac cga tac     4302
 Ile Ser Trp Leu Lys Asn Asp Gln Pro Val Thr Phe Leu Asp Arg Tyr
                1370                1375                1380

 cgc atg gaa gtg agg ggg aca gag gtc acc atc acc att gag aag gtc     4350
 Arg Met Glu Val Arg Gly Thr Glu Val Thr Ile Thr Ile Glu Lys Val
            1385                1390                1395

 aac agt gaa gac agc ggc cgc tac ggc gtc ttc gtc aag aac aag tat     4398
 Asn Ser Glu Asp Ser Gly Arg Tyr Gly Val Phe Val Lys Asn Lys Tyr
        1400                1405                1410

 ggc tcc gag acg ggc cag gtc acc atc agt gtg ttc aag cac ggg gac     4446
 Gly Ser Glu Thr Gly Gln Val Thr Ile Ser Val Phe Lys His Gly Asp
    1415                1420                1425

 gag ccc aag gag ctg aag agc atg tga cagcg tgtgtccagg cacagtctga     4498
 Glu Pro Lys Glu Leu Lys Ser Met 
1430                1435

 gtctagtctg catggaccag tagggacaac ctgtaccagg gtcacagcct ggcacaggct   4558

 acaggggtgg ggcagaagga aaggggacaa gatagaaccc aggatgtgag ggtgggggtg   4618

 gagcggatgc accaaagtgg agaagcaaag atctttctgg ggtcctgagt ggcttccagg   4678

 agagcgggat gaaccctgga cctggagtag gagacccgga tgcactgggg ctatctaaca   4738

 gtactggcat ctgataggta gaggtcaggt acgctgctaa acactgcagc tcccaccaca   4798

 tagaattatc cgaccccaga tgtcaaaagt gccaagggcc atgagccctg ccataaactg   4858

 atacatcgca cccctctttt aggatcccat agtttcaatt catgtaagtt caacagacac   4918

 ctgaagtcta gcatgtggga ggctgaggat ggagctggga acacaaaggc agctgataag   4978

 caggttctgc ttgcaaagag gcctcagtcc agtgggagaa acagacctgg gcgcaaacaa   5038

 ctccaggaca aggcaggaca tgataaagat tataaagcag gtccaaggaa agtgccgcca   5098

 gtggtccaag gagggagaca gagggtcgtc ccaacagggg gaggtagggc tttgaaaaca   5158

 ccttcatcca ggctgggcga ggtggctcac gcctgtaatc ccagtagttt gggaggccaa   5218

 ggcgggcaga tcacctgagg tcaggagttt tagaccagcc tggccaacat gacgaaaccc   5278

 ggtctctact aaaaatacaa aaattagcca ggcgtggtgg caggtgcctg taatcccggc   5338

 tattcagaag gccgaggtgg gagaatccgt tgaacctggg aggcggaggt tgtgatgagc   5398

 caagattgag ccaaaaaaaa attagcagaa ttggtgttgg gccctgaaaa attagtccga   5458

 ttttgtggtg gtaatgggag aaggacatcc caggagcagg gtctggtggg aggaaaggga   5518

 aggaggaggc taaggctgcc caggaggcct tggataccag gcttggagct ggtaacctcc   5578

 agggcttcca gcacggggcc tctgcctggt gtgacagata ccggctggcc tcacttgatg   5638

 gatctcagta ctgagctggg catttctctg ccccccaact tttttctttt taaaaataag   5698

 atggggagtg ttcataaaat tatagatgtt tgttgtaaaa ttttggaaaa ccctggaaat   5758

 tatagagaaa ataaacataa tctatactcc caaaaaaaaa aaaa                    5802




      <210> 403
      <211> 936
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(868)

      <400> 403
 ttttttataa tgccaacttt gtacaaaaaa gcaggcttta attaaggagg ttaacacc       58                                                                 
 atg gca gcg gcc act ctg agg acg cca act cag ggc act gtg aca ttt      106
 Met Ala Ala Ala Thr Leu Arg Thr Pro Thr Gln Gly Thr Val Thr Phe
   1               5                  10                  15

 gaa gat gtg gcc gta cac ttc tcc tgg gag gaa tgg ggt ctc ctt gat      154
 Glu Asp Val Ala Val His Phe Ser Trp Glu Glu Trp Gly Leu Leu Asp
              20                  25                  30

 gag gct caa aga tgc ctg tac cgt gat gtg atg ctg gag aac ttg gct      202
 Glu Ala Gln Arg Cys Leu Tyr Arg Asp Val Met Leu Glu Asn Leu Ala
          35                  40                  45

 ctt tta acc tct cta gat gtt cat cat cag aag cag cac ctt gga gaa      250
 Leu Leu Thr Ser Leu Asp Val His His Gln Lys Gln His Leu Gly Glu
      50                  55                  60

 aaa cat ttc aga agc aat gtg ggc aga gcc ttg ttt gtg aag acc tgc      298
 Lys His Phe Arg Ser Asn Val Gly Arg Ala Leu Phe Val Lys Thr Cys
  65                  70                  75                  80

 aca ttc cat gtg tca ggg gag cct tcc acc tgc aga gaa gtt ggg aag      346
 Thr Phe His Val Ser Gly Glu Pro Ser Thr Cys Arg Glu Val Gly Lys
                  85                  90                  95

 gac ttc ctg gcc aag ttg gga ttt ctc cat caa cag gct gct cac act      394
 Asp Phe Leu Ala Lys Leu Gly Phe Leu His Gln Gln Ala Ala His Thr
             100                 105                 110

 ggg gag caa tca aat agc aaa agc gac gtt ggg gcc atc agt cac aga      442
 Gly Glu Gln Ser Asn Ser Lys Ser Asp Val Gly Ala Ile Ser His Arg
         115                 120                 125

 gga aaa act cat tac aac tgt gga gaa cac aca aaa gca ttc ggc agt      490
 Gly Lys Thr His Tyr Asn Cys Gly Glu His Thr Lys Ala Phe Gly Ser
     130                 135                 140

 aaa cac aca ctt gtt cag cag cag aga acc ctc act aca gaa aga tgt      538
 Lys His Thr Leu Val Gln Gln Gln Arg Thr Leu Thr Thr Glu Arg Cys
 145                 150                 155                 160

 tac ata tgc agt gaa tgt ggg aaa tcc ttt agc aaa agc tac agt ctc      586
 Tyr Ile Cys Ser Glu Cys Gly Lys Ser Phe Ser Lys Ser Tyr Ser Leu
                 165                 170                 175

 aat gac cat tgg aga ctt cac act gga gaa aag cct tat gaa tgt cga      634
 Asn Asp His Trp Arg Leu His Thr Gly Glu Lys Pro Tyr Glu Cys Arg
             180                 185                 190

 gag tgt ggg aag tcc ttt agg caa agc tct agt ctc att cag cac cgg      682
 Glu Cys Gly Lys Ser Phe Arg Gln Ser Ser Ser Leu Ile Gln His Arg
         195                 200                 205

 aga gtt cac act gca gta cga cct cat gaa tgt gat gaa tgt gga aaa      730
 Arg Val His Thr Ala Val Arg Pro His Glu Cys Asp Glu Cys Gly Lys
     210                 215                 220

 tta ttt agc aac aag tct aac ctc att aaa cat cgg aga gtt cac act      778
 Leu Phe Ser Asn Lys Ser Asn Leu Ile Lys His Arg Arg Val His Thr
 225                 230                 235                 240

 ggg gag aag cct tat gag tgc acg gaa tgt ggg aaa tcc ttt agc cat      826
 Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys Ser Phe Ser His
                 245                 250                 255

 aac tcc agc ctt att aaa cat cag aga att cat agt cga taa aaggctt      875
 Asn Ser Ser Leu Ile Lys His Gln Arg Ile His Ser Arg 
             260                 265

 accgaggtac ctgctagcgt cgatacccag ctttcttgta caaagttggc attataagaa    935

 a                                                                    936




      <210> 404
      <211> 684
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(616)

      <400> 404
 ttttttataa tgccaacttt gtacaaaaaa gcaggcttta attaaggagg ttaacacc       58                                                                 
 atg gca gcg gcc act ctg agg acg cca act cag ggc act gtg acc ttt      106
 Met Ala Ala Ala Thr Leu Arg Thr Pro Thr Gln Gly Thr Val Thr Phe
   1               5                  10                  15

 gaa gat gtg gcc gta cac ttc tcc tgg gag gaa tgg ggt ctc ctt gat      154
 Glu Asp Val Ala Val His Phe Ser Trp Glu Glu Trp Gly Leu Leu Asp
              20                  25                  30

 gag gct caa aga tgc ctg tac cgt gat gtg atg ctg gag aac ttg gct      202
 Glu Ala Gln Arg Cys Leu Tyr Arg Asp Val Met Leu Glu Asn Leu Ala
          35                  40                  45

 ctt tta acc tct cta gat gtt cat cat cag aag cag cac ctt gga gaa      250
 Leu Leu Thr Ser Leu Asp Val His His Gln Lys Gln His Leu Gly Glu
      50                  55                  60

 aaa cat ttc aga agc aat gtg ggc aga gcc ttg ttt gtg aag acc tgc      298
 Lys His Phe Arg Ser Asn Val Gly Arg Ala Leu Phe Val Lys Thr Cys
  65                  70                  75                  80

 aca ttc cat gtg tca ggg gag cct tcc acc tgc aga gaa gtt ggg aag      346
 Thr Phe His Val Ser Gly Glu Pro Ser Thr Cys Arg Glu Val Gly Lys
                  85                  90                  95

 gac ttc ctg gcc aag ttg gga ttt ctc cat caa cag gct gct cac act      394
 Asp Phe Leu Ala Lys Leu Gly Phe Leu His Gln Gln Ala Ala His Thr
             100                 105                 110

 ggg gag caa tca aat agc aaa agc gac ggt ggg gcc atc agt cac aga      442
 Gly Glu Gln Ser Asn Ser Lys Ser Asp Gly Gly Ala Ile Ser His Arg
         115                 120                 125

 gga aaa act cat tac aac tgt gga gaa cac aca aaa gca ttc agc ggt      490
 Gly Lys Thr His Tyr Asn Cys Gly Glu His Thr Lys Ala Phe Ser Gly
     130                 135                 140

 aaa cac aca ctt gtt cag cag cag aga acc ctc act aca gaa aga tgt      538
 Lys His Thr Leu Val Gln Gln Gln Arg Thr Leu Thr Thr Glu Arg Cys
 145                 150                 155                 160

 tac ata tgc agt gaa tgt ggg aaa tcc ttt agc cat aac tcc agc ctt      586
 Tyr Ile Cys Ser Glu Cys Gly Lys Ser Phe Ser His Asn Ser Ser Leu
                 165                 170                 175

 att aaa cat cag aga att cat agt cga taa a aggcttaccg aggtacctgc      637
 Ile Lys His Gln Arg Ile His Ser Arg 
             180                 185

 tagcgtcgat acccagcttt cttgtacaaa gttggcatta taagaaa                  684




      <210> 405
      <211> 639
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(571)

      <400> 405
 ttttttataa tgccaacttt gtacaaaaaa gcaggcttta attaaggagg ctaacacc       58                                                                 
 atg gtc agc tcc tgt tgt ggt tcc gtc tgc tct gac cag ggc tgt ggc      106
 Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly
   1               5                  10                  15

 ctg gag acc tgc tgc cgc ccc agc tgc tgt cag acc acc tgc tgc agg      154
 Leu Glu Thr Cys Cys Arg Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg
              20                  25                  30

 acc acc tgc tgc cgc ccc agc tgc tgt gtg tcc agc tgc tgc aga ccc      202
 Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro
          35                  40                  45

 cag tgc tgc cag tct gtg tgc tgc cag ccc acc tgc tgc cgt ccc agc      250
 Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser
      50                  55                  60

 tgc tgc acc agc tgc tgt cag acc acc tgc tgc agg acc acc tgc tgt      298
 Cys Cys Thr Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys
  65                  70                  75                  80

 cgc cct agc tgc tgt gta tcc agc tgc tgc aga ccc cag tgc tgc cag      346
 Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln
                  85                  90                  95

 tct gtg tgc tgc cag cca acc tgc tgc cgt ccc agc tgc tgc atc tcc      394
 Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys Cys Ile Ser
             100                 105                 110

 agc tgc tgc cgc ccc tct tgc tgt gaa tcc agc tgc tgc cgc ccg tgc      442
 Ser Cys Cys Arg Pro Ser Cys Cys Glu Ser Ser Cys Cys Arg Pro Cys
         115                 120                 125

 tgc tgc cgc ccc tgc tgc tgc ctg cgt cca gtc tgt ggc cga gtc tcc      490
 Cys Cys Arg Pro Cys Cys Cys Leu Arg Pro Val Cys Gly Arg Val Ser
     130                 135                 140

 tgc cac acc act tgc tat cgc cca acc tgt gtc att tcc acc tgc ccc      538
 Cys His Thr Thr Cys Tyr Arg Pro Thr Cys Val Ile Ser Thr Cys Pro
 145                 150                 155                 160

 cgt ccc ttg tgc tgt gcc tcc tct tgc tgc tga gcccacta ccgaggtacc      589
 Arg Pro Leu Cys Cys Ala Ser Ser Cys Cys 
                 165                 170

 tgctagggct gctacccagc tttcttgtac aaagttggca ttataaaaaa               639




      <210> 406
      <211> 354
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(286)

      <400> 406
 ttttttataa tgccaacttt gtacaaaaaa gcaggcttta attaaggagg ttaacacc       58                                                                 
 atg gtc agc tcc tgt tgt ggt tcc gtc tgc tct gac cag ggc tgt ggc      106
 Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly
   1               5                  10                  15

 ctg gag acc tgc tgc cgt ccc agc tgc tgt ccc agc tgc tgt cag acc      154
 Leu Glu Thr Cys Cys Arg Pro Ser Cys Cys Pro Ser Cys Cys Gln Thr
              20                  25                  30

 acc tgc tgc agg acc acc tgc tgc cgc cct agc tgc tgt gtg tcc agc      202
 Thr Cys Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser
          35                  40                  45

 tgc tgc aga ccc cag tgc tgc cag tct gtg tgc tgc cag ccc acc tgc      250
 Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys
      50                  55                  60

 ccc cgt ccc ttg tgc tgt gcc tcc tct tgc tgc tga gccc actaccgagg      300
 Pro Arg Pro Leu Cys Cys Ala Ser Ser Cys Cys 
  65                  70                  75

 tacctgctag cgctgctacc cagctttctt gtacaaagtt ggcattataa gaaa          354




      <210> 407
      <211> 744
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(676)

      <400> 407
 ttttttataa tgccaacttt gtacaaaaaa gcaggcttta attaaggagg ttaacacc       58                                                                 
 atg gtc agc tcc tgt tgt ggt tcc gtc tgc tct gac cag ggc tgt ggc      106
 Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly
   1               5                  10                  15

 ctg gag acc tgc tgc cgc ccc agc tgc tgt cag acc acc tgc tgc agg      154
 Leu Glu Thr Cys Cys Arg Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg
              20                  25                  30

 acc acc tgc tgc cgc ccc agc tgc tgt gtg tcc agc tgc tgc aga ccc      202
 Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro
          35                  40                  45

 cag tgc tgc cag tct gtg tgc tgc cag ccc acc tgc tgc cgt ccc agc      250
 Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser
      50                  55                  60

 tgc tgt ccc agc tgc tgt cag acc acc tgc tgc agg acc acc tgc tgc      298
 Cys Cys Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys
  65                  70                  75                  80

 cgc cct agc tgc tgt gta tcc agc tgc tgc aga ccc cag tgc tgc cag      346
 Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln
                  85                  90                  95

 tct gtg tgc tgc cag ccc act tgc tgc cgt ccc agc tgc agc atc tcc      394
 Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys Ser Ile Ser
             100                 105                 110

 agc tgc tgt cgc ccc agc tgc tgt gtg tcc agg tgc tgc agg tcc cag      442
 Ser Cys Cys Arg Pro Ser Cys Cys Val Ser Arg Cys Cys Arg Ser Gln
         115                 120                 125

 tgc tgc cag tct gtg tgc tgc cag cca acc tgc tgc cgt ccc agc tgc      490
 Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys
     130                 135                 140

 tgc atc tcc agc tgc tgc cgc ccc tct tgc tgt gaa tcc agc tgc tgc      538
 Cys Ile Ser Ser Cys Cys Arg Pro Ser Cys Cys Glu Ser Ser Cys Cys
 145                 150                 155                 160

 cgc ccg tgc tgc tgc cgc ccc tgc tgc tgc ctg cgt cca gtc tgt ggc      586
 Arg Pro Cys Cys Cys Arg Pro Cys Cys Cys Leu Arg Pro Val Cys Gly
                 165                 170                 175

 cga gtc tcc tgc cac acc act tgc tat cgc cca acc tgt gtc att tcc      634
 Arg Val Ser Cys His Thr Thr Cys Tyr Arg Pro Thr Cys Val Ile Ser
             180                 185                 190

 acc tgc ccc cgt ccc ttg tgc tgt gcc tcc tct tgc tgc tga gcccact      683
 Thr Cys Pro Arg Pro Leu Cys Cys Ala Ser Ser Cys Cys 
         195                 200                 205

 accgaggtac ctgctagcgc tgctacccag ctttcttgta caaagttggc attataagaa    743

 a                                                                    744




      <210> 408
      <211> 2035
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (189)..(1418)

      <400> 408
 ccaactaagc ttgcctaatt tgcttcagaa ttggaagagg gaattgcagc aggaaaatat     60

 gtgaagagtt tttaaaccca caaattcttc ttactttaga attagttgtt acattggcag    120

 gaaaaaataa atgcagatgt tggaccatgt tggaaacctt gtcaagacag tggattgtct    180

 cacacaga atg gaa atg tgg ctt ctg att ctg gtg gcg tat atg ttc cag     230
          Met Glu Met Trp Leu Leu Ile Leu Val Ala Tyr Met Phe Gln
            1               5                  10

 aga aat gtg aat tca gta cat atg cca act aaa gct gtg gac cca gaa      278
 Arg Asn Val Asn Ser Val His Met Pro Thr Lys Ala Val Asp Pro Glu
  15                  20                  25                  30

 gca ttc atg aat att agt gaa atc atc caa cat caa ggc tat ccc tgt      326
 Ala Phe Met Asn Ile Ser Glu Ile Ile Gln His Gln Gly Tyr Pro Cys
                  35                  40                  45

 gag gaa tat gaa gtc gca act gaa gat ggg tat atc ctt tct gtt aac      374
 Glu Glu Tyr Glu Val Ala Thr Glu Asp Gly Tyr Ile Leu Ser Val Asn
              50                  55                  60

 agg att cct cga ggc cta gtg caa cct aag aag aca ggt tcc agg cct      422
 Arg Ile Pro Arg Gly Leu Val Gln Pro Lys Lys Thr Gly Ser Arg Pro
          65                  70                  75

 gtg gtg tta ctg cag cat ggc cta gtt gga ggt gct agc aac tgg att      470
 Val Val Leu Leu Gln His Gly Leu Val Gly Gly Ala Ser Asn Trp Ile
      80                  85                  90

 tcc aac ctg ccc aac aat agc ctg ggc ttc att ctg gca gat gct ggt      518
 Ser Asn Leu Pro Asn Asn Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly
  95                 100                 105                 110

 ttt gac gtg tgg atg ggg aac agc agg gga aac gcc tgg tct cga aaa      566
 Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Ala Trp Ser Arg Lys
                 115                 120                 125

 cac aag aca ctc tcc ata gac caa gat gag ttc tgg gct ttc agt tat      614
 His Lys Thr Leu Ser Ile Asp Gln Asp Glu Phe Trp Ala Phe Ser Tyr
             130                 135                 140

 gat gag atg gct agg ttt gac ctt cct gca gtg ata aac ttt att ttg      662
 Asp Glu Met Ala Arg Phe Asp Leu Pro Ala Val Ile Asn Phe Ile Leu
         145                 150                 155

 cag aaa acg ggc cag gaa aag atc tat tat gtc ggc tat tca cag ggc      710
 Gln Lys Thr Gly Gln Glu Lys Ile Tyr Tyr Val Gly Tyr Ser Gln Gly
     160                 165                 170

 acc acc atg ggc ttt att gca ttt tcc acc atg cca gag ctg gct cag      758
 Thr Thr Met Gly Phe Ile Ala Phe Ser Thr Met Pro Glu Leu Ala Gln
 175                 180                 185                 190

 aaa atc aaa atg tat ttt gct tta gca ccc ata gcc act gtt aag cat      806
 Lys Ile Lys Met Tyr Phe Ala Leu Ala Pro Ile Ala Thr Val Lys His
                 195                 200                 205

 gca aaa agc ccc ggg acc aaa ttt ttg ttg ctg cca gat atg atg atc      854
 Ala Lys Ser Pro Gly Thr Lys Phe Leu Leu Leu Pro Asp Met Met Ile
             210                 215                 220

 aag gga ttg ttt ggc aaa aaa gaa ttt ctg tat cag acc aga ttt ctc      902
 Lys Gly Leu Phe Gly Lys Lys Glu Phe Leu Tyr Gln Thr Arg Phe Leu
         225                 230                 235

 aga caa ctt gtt att tac ctt tgt ggc cag gtg att ctt gat cag att      950
 Arg Gln Leu Val Ile Tyr Leu Cys Gly Gln Val Ile Leu Asp Gln Ile
     240                 245                 250

 tgt agt aat atc atg tta ctt ctg ggt gga ttc aac acc aac aat atg      998
 Cys Ser Asn Ile Met Leu Leu Leu Gly Gly Phe Asn Thr Asn Asn Met
 255                 260                 265                 270

 aac atg agc cga gca agt gta tat gct gcc cac act ctt gct gga aca     1046
 Asn Met Ser Arg Ala Ser Val Tyr Ala Ala His Thr Leu Ala Gly Thr
                 275                 280                 285

 tct gtg caa aat att cta cac tgg agc cag gca gtg aat tct ggt gaa     1094
 Ser Val Gln Asn Ile Leu His Trp Ser Gln Ala Val Asn Ser Gly Glu
             290                 295                 300

 ctc cgg gca ttt gac tgg ggg agt gag acc aaa aat ctg gaa aaa tgc     1142
 Leu Arg Ala Phe Asp Trp Gly Ser Glu Thr Lys Asn Leu Glu Lys Cys
         305                 310                 315

 aat cag cca act cct gta agg tac aga gtc aga gat atg acg gtc cct     1190
 Asn Gln Pro Thr Pro Val Arg Tyr Arg Val Arg Asp Met Thr Val Pro
     320                 325                 330

 aca gca atg tgg aca gga ggt cag gac tgg ctt tca aat cca gaa gac     1238
 Thr Ala Met Trp Thr Gly Gly Gln Asp Trp Leu Ser Asn Pro Glu Asp
 335                 340                 345                 350

 gtg aaa atg ctg ctc tct gag gtg acc aac ctc atc tac cat aag aat     1286
 Val Lys Met Leu Leu Ser Glu Val Thr Asn Leu Ile Tyr His Lys Asn
                 355                 360                 365

 att cct gaa tgg gct cat gtg gat ttc atc tgg ggt ttg gat gct cct     1334
 Ile Pro Glu Trp Ala His Val Asp Phe Ile Trp Gly Leu Asp Ala Pro
             370                 375                 380

 cac cgt atg tac aat gaa atc atc cat ctg atg cag cag gag gag acc     1382
 His Arg Met Tyr Asn Glu Ile Ile His Leu Met Gln Gln Glu Glu Thr
         385                 390                 395

 aac ctt tcc cag gga cgg tgt gag gcc gta ttg tga agca tctgacactg     1432
 Asn Leu Ser Gln Gly Arg Cys Glu Ala Val Leu 
     400                 405

 acgatcttag gacaacctcc tgagggatgg ggctaggacc catgaaggca gaattatgga   1492

 gagcagagac ctagtataca tttttcagat tccctgcact tggcactaaa tccgacactt   1552

 acatttacat tttttttctg taaattaaag tacttattag gtaaatagag gttttgtatg   1612

 ctattatata ttctaccatc ttgaagggta ggttttacct gatagccaga aaatatctag   1672

 acattctcta tatcattcag gtaaatctct ttaaaacacc tattgttttt tctataagcc   1732

 atatttttgg agcactaaag taaaatggca aattgggaca gatattgagg tctggagtct   1792

 gtggattatt gttgactttg acaaaataag ctagacattt tcaccttgtt gccacagaga   1852

 cataacacta cctcaggaag ctgagctgct ttaaggacaa caacaacaaa atcagtgtta   1912

 cagtatggat gaaatctatg ttaagcattc tcagaataag gccaagtttt atagttgcat   1972

 ctcagggaag aaaattttat aggatgttta tgagttctcc aataaatgca ttctgcatta   2032

 cat                                                                 2035




      <210> 409
      <211> 1384
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (9)..(1384)

      <400> 409
 ccaactaa gct tgc cta att tgc ttc aga att gga aga ggg aat tgc agc      50
          Ala Cys Leu Ile Cys Phe Arg Ile Gly Arg Gly Asn Cys Ser
            1               5                  10

 agg aaa ata tgt gaa gag ttt tta aac cca caa att ctt ctt act tta       98
 Arg Lys Ile Cys Glu Glu Phe Leu Asn Pro Gln Ile Leu Leu Thr Leu
  15                  20                  25                  30

 gaa tta gtt gtt aca ttg gca gga aaa aat aaa tgc aga tgt tgg acc      146
 Glu Leu Val Val Thr Leu Ala Gly Lys Asn Lys Cys Arg Cys Trp Thr
                  35                  40                  45

 atg ttg gaa acc ttg tca aga cag tgg att gtc tca cac aga atg gaa      194
 Met Leu Glu Thr Leu Ser Arg Gln Trp Ile Val Ser His Arg Met Glu
              50                  55                  60

 atg tgg ctt ctg att ctg gtg gcg tat atg ttc cag aga aat gtg aat      242
 Met Trp Leu Leu Ile Leu Val Ala Tyr Met Phe Gln Arg Asn Val Asn
          65                  70                  75

 tca gta cat atg cca act aaa gct gtg gac cca gaa gca ttc atg aat      290
 Ser Val His Met Pro Thr Lys Ala Val Asp Pro Glu Ala Phe Met Asn
      80                  85                  90

 att agt gaa atc atc caa cat caa ggc tat ccc tgt gag gaa tat gaa      338
 Ile Ser Glu Ile Ile Gln His Gln Gly Tyr Pro Cys Glu Glu Tyr Glu
  95                 100                 105                 110

 gtc gca act gaa gat ggg tat atc ctt tct gtt aac agg att cct cga      386
 Val Ala Thr Glu Asp Gly Tyr Ile Leu Ser Val Asn Arg Ile Pro Arg
                 115                 120                 125

 ggc cta gtg caa cct aag aag aca ggt tcc agg cct gtg gtg tta ctg      434
 Gly Leu Val Gln Pro Lys Lys Thr Gly Ser Arg Pro Val Val Leu Leu
             130                 135                 140

 cag cat ggc cta gtt gga ggt gct agc aac tgg att tcc aac ctg ccc      482
 Gln His Gly Leu Val Gly Gly Ala Ser Asn Trp Ile Ser Asn Leu Pro
         145                 150                 155

 aac aat agc ctg ggc ttc att ctg gca gat gct ggt ttt gac gtg tgg      530
 Asn Asn Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp
     160                 165                 170

 atg ggg aac agc agg gga aac gcc tgg tct cga aaa cac aag aca ctc      578
 Met Gly Asn Ser Arg Gly Asn Ala Trp Ser Arg Lys His Lys Thr Leu
 175                 180                 185                 190

 tcc ata gac caa gat gag ttc tgg gct ttc agt tat gat gag atg gct      626
 Ser Ile Asp Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala
                 195                 200                 205

 agg ttt gac ctt cct gca gtg ata aac ttt att ttg cag aaa acg ggc      674
 Arg Phe Asp Leu Pro Ala Val Ile Asn Phe Ile Leu Gln Lys Thr Gly
             210                 215                 220

 cag gaa aag atc tat tat gtc ggc tat tca cag ggc acc acc atg ggc      722
 Gln Glu Lys Ile Tyr Tyr Val Gly Tyr Ser Gln Gly Thr Thr Met Gly
         225                 230                 235

 ttt att gca ttt tcc acc atg cca gag ctg gct cag aaa atc aaa atg      770
 Phe Ile Ala Phe Ser Thr Met Pro Glu Leu Ala Gln Lys Ile Lys Met
     240                 245                 250

 tat ttt gct tta gca ccc ata gcc act gtt aag cat gca aaa agc ccc      818
 Tyr Phe Ala Leu Ala Pro Ile Ala Thr Val Lys His Ala Lys Ser Pro
 255                 260                 265                 270

 ggg acc aaa ttt ttg ttg ctg cca gat atg atg atc aag gga ttg ttt      866
 Gly Thr Lys Phe Leu Leu Leu Pro Asp Met Met Ile Lys Gly Leu Phe
                 275                 280                 285

 ggc aaa aaa gaa ttt ctg tat cag acc aga ttt ctc aga caa ctt gtt      914
 Gly Lys Lys Glu Phe Leu Tyr Gln Thr Arg Phe Leu Arg Gln Leu Val
             290                 295                 300

 att tac ctt tgt ggc cag gtg att ctt gat cag att tgt agt aat atc      962
 Ile Tyr Leu Cys Gly Gln Val Ile Leu Asp Gln Ile Cys Ser Asn Ile
         305                 310                 315

 atg tta ctt ctg ggt gga ttc aac acc aac aat atg aac atg agc cga     1010
 Met Leu Leu Leu Gly Gly Phe Asn Thr Asn Asn Met Asn Met Ser Arg
     320                 325                 330

 gca agt gta tat gct gcc cac act ctt gct gga aca tct gtg caa aat     1058
 Ala Ser Val Tyr Ala Ala His Thr Leu Ala Gly Thr Ser Val Gln Asn
 335                 340                 345                 350

 att cta cac tgg agc cag gca gtg aat tct ggt gaa ctc cgg gca ttt     1106
 Ile Leu His Trp Ser Gln Ala Val Asn Ser Gly Glu Leu Arg Ala Phe
                 355                 360                 365

 gac tgg ggg agt gag acc aaa aat ctg gaa aaa tgc aat cag cca act     1154
 Asp Trp Gly Ser Glu Thr Lys Asn Leu Glu Lys Cys Asn Gln Pro Thr
             370                 375                 380

 cct gta agg tac aga gtc aga gat atg acg gtc cct aca gca atg tgg     1202
 Pro Val Arg Tyr Arg Val Arg Asp Met Thr Val Pro Thr Ala Met Trp
         385                 390                 395

 aca gga ggt cag gac tgg ctt tca aat cca gaa gac gtg aaa atg ctg     1250
 Thr Gly Gly Gln Asp Trp Leu Ser Asn Pro Glu Asp Val Lys Met Leu
     400                 405                 410

 ctc tct gag gtg acc aac ctc atc tac cat aag aat att cct gaa tgg     1298
 Leu Ser Glu Val Thr Asn Leu Ile Tyr His Lys Asn Ile Pro Glu Trp
 415                 420                 425                 430

 gct cat gtg gat ttc atc tgg ggt ttg gat gct cct cac cgt atg tac     1346
 Ala His Val Asp Phe Ile Trp Gly Leu Asp Ala Pro His Arg Met Tyr
                 435                 440                 445

 aat gaa atc atc cat ctg atg cag cag gag gag acc at                  1384
 Asn Glu Ile Ile His Leu Met Gln Gln Glu Glu Thr 
             450                 455





      <210> 410
      <211> 1171
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (134)..(1171)

      <400> 410
 taccggtccg gaattcccgg gtcgacccac gcgtccgtac aactttgcca gcactacagc     60

 ctaagcttcc agagtggaca cggagaaggg catcagaaaa ccattctggt gaggtccaca    120

 cccataagtc acc   atg tac aag gac tgc atc gag tcc act gga gac tat     169
                  Met Tyr Lys Asp Cys Ile Glu Ser Thr Gly Asp Tyr
                    1               5                  10

 ttt ctt ctc tgt gac gcc gag ggg cca tgg ggc atc att ctg gag tcc      217
 Phe Leu Leu Cys Asp Ala Glu Gly Pro Trp Gly Ile Ile Leu Glu Ser
          15                  20                  25

 ctg gcc ata ctt ggc atc gtg gtc aca att ctg cta ctc tta gca ttt      265
 Leu Ala Ile Leu Gly Ile Val Val Thr Ile Leu Leu Leu Leu Ala Phe
      30                  35                  40

 ctc ttc ctc atg cga aag atc caa gac tgc agc cag tgg aat gtc ctc      313
 Leu Phe Leu Met Arg Lys Ile Gln Asp Cys Ser Gln Trp Asn Val Leu
  45                  50                  55                  60

 ccc acc cag ctc ctc ttc ctc ctg agt gtc ctg ggg ctc ttc gga ctc      361
 Pro Thr Gln Leu Leu Phe Leu Leu Ser Val Leu Gly Leu Phe Gly Leu
                  65                  70                  75

 gct ttt gcc ttc atc atc gag ctc aat caa caa act gcc ccc gta cgc      409
 Ala Phe Ala Phe Ile Ile Glu Leu Asn Gln Gln Thr Ala Pro Val Arg
              80                  85                  90

 tac ttt ctc ttt ggg gtt ctc ttt gct ctc tgt ttc tca tgc ctc tta      457
 Tyr Phe Leu Phe Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu
          95                 100                 105

 gct cat gcc tcc aat cta gtg aag ctg gtt cgg ggt tgt gtc tcc ttc      505
 Ala His Ala Ser Asn Leu Val Lys Leu Val Arg Gly Cys Val Ser Phe
     110                 115                 120

 tcc tgg acg aca att ctg tgc att gct att ggt tgc agt ctg ttg caa      553
 Ser Trp Thr Thr Ile Leu Cys Ile Ala Ile Gly Cys Ser Leu Leu Gln
 125                 130                 135                 140

 atc att att gcc act gag tat gtg act ctc atc atg acc aga ggt atg      601
 Ile Ile Ile Ala Thr Glu Tyr Val Thr Leu Ile Met Thr Arg Gly Met
                 145                 150                 155

 atg ttt gtg aat atg aca ccc tgc cag ctc aat gtg gac ttt gtt gta      649
 Met Phe Val Asn Met Thr Pro Cys Gln Leu Asn Val Asp Phe Val Val
             160                 165                 170

 ctc ctg gtc tat gtc ctc ttc ctg atg gcc ctc aca ttc ttc gtc tcc      697
 Leu Leu Val Tyr Val Leu Phe Leu Met Ala Leu Thr Phe Phe Val Ser
         175                 180                 185

 aaa gcc acc ttc tgt ggc ccg ggt gag aac tgg aag cag cat gga agg      745
 Lys Ala Thr Phe Cys Gly Pro Gly Glu Asn Trp Lys Gln His Gly Arg
     190                 195                 200

 ctc atc ttt atc act gtg ctc ttc tcc atc atc atc tgg gtg gtg tgg      793
 Leu Ile Phe Ile Thr Val Leu Phe Ser Ile Ile Ile Trp Val Val Trp
 205                 210                 215                 220

 atc tcc atg ctc ctg aga ggc aac ccg cag ttc cag cga cag ccc cag      841
 Ile Ser Met Leu Leu Arg Gly Asn Pro Gln Phe Gln Arg Gln Pro Gln
                 225                 230                 235

 tgg gat gac ccg gtc gtc tgc att gct ctg gtc acc aac gca tgg gtt      889
 Trp Asp Asp Pro Val Val Cys Ile Ala Leu Val Thr Asn Ala Trp Val
             240                 245                 250

 ttc ctg ctg ctg tac atc gtc cct gag ctc tgc att ctc tac aga tcg      937
 Phe Leu Leu Leu Tyr Ile Val Pro Glu Leu Cys Ile Leu Tyr Arg Ser
         255                 260                 265

 tgt aga cag gag tgc cct tta caa ggc aat gcc tgc ccc gtc aca gcc      985
 Cys Arg Gln Glu Cys Pro Leu Gln Gly Asn Ala Cys Pro Val Thr Ala
     270                 275                 280

 tac caa cac agc ttc caa gtg gag aac cag gag ctc tcc aga gcc cga     1033
 Tyr Gln His Ser Phe Gln Val Glu Asn Gln Glu Leu Ser Arg Ala Arg
 285                 290                 295                 300

 gac agt gat gga gct gag gag gat gta gca tta act tca tat ggt act     1081
 Asp Ser Asp Gly Ala Glu Glu Asp Val Ala Leu Thr Ser Tyr Gly Thr
                 305                 310                 315

 ccc att cag ccg cag act gtt gat ccc aca caa gag tgt ttc atc cca     1129
 Pro Ile Gln Pro Gln Thr Val Asp Pro Thr Gln Glu Cys Phe Ile Pro
             320                 325                 330

 cag gct aaa cta agc ccc cag caa gat gca gga gga gta taa             1171
 Gln Ala Lys Leu Ser Pro Gln Gln Asp Ala Gly Gly Val 
         335                 340                 345





      <210> 411
      <211> 1500
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (101)..(778)

      <400> 411
 cacagtaaga gattatagca aagcatctat aatcaactca gcttaagaag ttttgacctt     60

 ctgggtaggc ttcttgccac aacagaacag caccataacc  atg gct ttc ttc tcc     115
                                              Met Ala Phe Phe Ser
                                                1               5

 cga ctg aat ctc cag gag ggc ctc caa acc ttc ttt gtt ttg caa tgg      163
 Arg Leu Asn Leu Gln Glu Gly Leu Gln Thr Phe Phe Val Leu Gln Trp
                  10                  15                  20

 atc cca gtc tat ata ttt tta gga gct att ccc att ctc ctt ata ccc      211
 Ile Pro Val Tyr Ile Phe Leu Gly Ala Ile Pro Ile Leu Leu Ile Pro
              25                  30                  35

 tac ttt ctg tta ttc agt aag ttc tgg ccc ttg gct gtg ctc tcc tta      259
 Tyr Phe Leu Leu Phe Ser Lys Phe Trp Pro Leu Ala Val Leu Ser Leu
          40                  45                  50

 gcc tgg ctc acc tat gat tgg aac acc cac agt caa ggt ggc agg cgt      307
 Ala Trp Leu Thr Tyr Asp Trp Asn Thr His Ser Gln Gly Gly Arg Arg
      55                  60                  65

 tca gct tgg gta cga aac tgg acc cta tgg aag tat ttc cga aat tac      355
 Ser Ala Trp Val Arg Asn Trp Thr Leu Trp Lys Tyr Phe Arg Asn Tyr
  70                  75                  80                  85

 ttc cca gta aag ctg gtg aag act cat gat ctt tct ccc aaa cac aac      403
 Phe Pro Val Lys Leu Val Lys Thr His Asp Leu Ser Pro Lys His Asn
                  90                  95                 100

 tac atc att gcc aat cac ccc cat ggc att ctc tct ttt ggt gtc ttc      451
 Tyr Ile Ile Ala Asn His Pro His Gly Ile Leu Ser Phe Gly Val Phe
             105                 110                 115

 atc aac ttt gcc act gag gcc act ggc att gct cgg att ttc cca tcc      499
 Ile Asn Phe Ala Thr Glu Ala Thr Gly Ile Ala Arg Ile Phe Pro Ser
         120                 125                 130

 atc act ccc ttt gta ggg acc tta gaa agg ata ttt tgg atc cca att      547
 Ile Thr Pro Phe Val Gly Thr Leu Glu Arg Ile Phe Trp Ile Pro Ile
     135                 140                 145

 gtg cga gaa tat gtg atg tca atg ggt gtg tgc cct gtg agt agc tca      595
 Val Arg Glu Tyr Val Met Ser Met Gly Val Cys Pro Val Ser Ser Ser
 150                 155                 160                 165

 gcc ttg aag tac ttg ctg acc cag aaa ggc tca ggc aat gcc gtg gtt      643
 Ala Leu Lys Tyr Leu Leu Thr Gln Lys Gly Ser Gly Asn Ala Val Val
                 170                 175                 180

 att gtg gtg ggt gga gct gct gaa gct ctc ttg tgc cga cca gga gcc      691
 Ile Val Val Gly Gly Ala Ala Glu Ala Leu Leu Cys Arg Pro Gly Ala
             185                 190                 195

 tcc act ctc ttc ctc aag cag cgt aaa ggt ttt gtg aag atg gca ctg      739
 Ser Thr Leu Phe Leu Lys Gln Arg Lys Gly Phe Val Lys Met Ala Leu
         200                 205                 210

 caa aca ggt tgg gga acc cct tcc aat tcc cag gat taa gaggccaaac       788
 Gln Thr Gly Trp Gly Thr Pro Ser Asn Ser Gln Asp 
     215                 220                 225

 cagaagacag tagacaagta tcacgcactc tacatcagtg ccctgcgcaa gctctttgac    848

 caacacaaag ttgaatatgg cctccctgag acccaagagc tgacaattac ataacaggag    908

 ccacattccc cattgatcaa cccccaaagc catgagggat ccaagtagag ccacagaaaa    968

 agaagaattc caggagaggg aaagatcgta aggatgagag aggagaccat ccaagccaga   1028

 aattatttaa taaatcagag ttctagcaat agagtcctct cccaagtggc tgaggcaggc   1088

 ttaggggaaa gaaccagagg ggcaggggag gactggggag ggctggctag ccagaggagt   1148

 tggctgtatc acccctggtt attttagggc aacaacccag ttggggagtc ttatgaatca   1208

 ttccagccaa ctctctgatc acaaagaata ctgtgcccct ttctcctaaa ccttagttca   1268

 ccatcactac gtaggtttag acttagaagc tttatttgga acagggatag tttgtttcct   1328

 cttggtcctt tccttacaac ttgggaactg ccacaaggta aaccagggac ctgaactgta   1388

 gctgcctggt ccaagcagac aggattccgt cagttgtgat agagttctag attggcaatg   1448

 cagttacatt gtttcttctt tgaaaataaa gttctagaca tataaaaaaa aa           1500




      <210> 412
      <211> 858
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (43)..(747)

      <400> 412
 tgaacttaat tttgggtcga cccacgcgtc cgcgcacaca ca   atg gtg cct gaa      54
                                                  Met Val Pro Glu
                                                    1

 gaa gag cct caa gac cga gag aaa gga ctc tgg tgg ttc cag ttg aag      102
 Glu Glu Pro Gln Asp Arg Glu Lys Gly Leu Trp Trp Phe Gln Leu Lys
   5                  10                  15                  20

 gtc tgg tcc atg gca gtc gta tcc atc ttg ctc ctc agt gtc tgt ttc      150
 Val Trp Ser Met Ala Val Val Ser Ile Leu Leu Leu Ser Val Cys Phe
                  25                  30                  35

 act gtg agt tct gtg gtg cct cac aat ttt atg tat agc aaa act gtc      198
 Thr Val Ser Ser Val Val Pro His Asn Phe Met Tyr Ser Lys Thr Val
              40                  45                  50

 aag agg ctg tcc aag tta cga gag tat caa cag tat cat tca agc ctg      246
 Lys Arg Leu Ser Lys Leu Arg Glu Tyr Gln Gln Tyr His Ser Ser Leu
          55                  60                  65

 acc tgc gtc atg gaa gga aag gac ata gaa gat tgg agc tgc tgc cca      294
 Thr Cys Val Met Glu Gly Lys Asp Ile Glu Asp Trp Ser Cys Cys Pro
      70                  75                  80

 acc cct tgg act tca ttt cag tct agt tgc tac ttt att tct act ggg      342
 Thr Pro Trp Thr Ser Phe Gln Ser Ser Cys Tyr Phe Ile Ser Thr Gly
  85                  90                  95                 100

 atg caa tct tgg act aag agt caa aag aac tgt tct gtg atg ggg gct      390
 Met Gln Ser Trp Thr Lys Ser Gln Lys Asn Cys Ser Val Met Gly Ala
                 105                 110                 115

 gat ctg gtg gtg atc aac acc acg gaa gaa cac gat ttc atc att cat      438
 Asp Leu Val Val Ile Asn Thr Thr Glu Glu His Asp Phe Ile Ile His
             120                 125                 130

 aat ctg aaa aga aat tct tct tat ttt ctg ggg ctg tca cat cca cgg      486
 Asn Leu Lys Arg Asn Ser Ser Tyr Phe Leu Gly Leu Ser His Pro Arg
         135                 140                 145

 ggt cgg cga cat tgg caa tgg gtt gac cac aca cca tac aat gaa aat      534
 Gly Arg Arg His Trp Gln Trp Val Asp His Thr Pro Tyr Asn Glu Asn
     150                 155                 160

 gtc aca ttc tgg cac tca ggt gaa ccc aat aac ctt gat gag cgt tgt      582
 Val Thr Phe Trp His Ser Gly Glu Pro Asn Asn Leu Asp Glu Arg Cys
 165                 170                 175                 180

 gcg ata ata aat ttc cgc tct tca caa gaa tgg ggc tgg aat gac att      630
 Ala Ile Ile Asn Phe Arg Ser Ser Gln Glu Trp Gly Trp Asn Asp Ile
                 185                 190                 195

 cac tgt cat gta cct cac aag tca att tgc gag atg aag aag atc tac      678
 His Cys His Val Pro His Lys Ser Ile Cys Glu Met Lys Lys Ile Tyr
             200                 205                 210

 ata tac atg aaa tat tct ccc tgg aaa tgt gtt tgg gtt ggc atc cac      726
 Ile Tyr Met Lys Tyr Ser Pro Trp Lys Cys Val Trp Val Gly Ile His
         215                 220                 225

 cgc tgt aga aag cta aat tga tt ttttaattta tgtgtaagat ttgtacaaag      779
 Arg Cys Arg Lys Leu Asn 
     230

 aatgccccta aatgtttcag caggctgtca cctattacac ttatgatata atccattcac    839

 acattcaaaa aaaaaaaag                                                 858




      <210> 413
      <211> 817
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (11)..(652)

      <400> 413
 cgcacacaca   atg gtg cct gaa gaa gag cct caa gac cga gag aaa gga      49
              Met Val Pro Glu Glu Glu Pro Gln Asp Arg Glu Lys Gly
                1               5                  10

 ctc tgg tgg ttc cag ttg aag gtc tgg tcc atg gca gtc gta tcc atc       97
 Leu Trp Trp Phe Gln Leu Lys Val Trp Ser Met Ala Val Val Ser Ile
      15                  20                  25

 ttg ctc ctc agt gtc tgt ttc act gtg agt tct gtg gtg cct cac aat      145
 Leu Leu Leu Ser Val Cys Phe Thr Val Ser Ser Val Val Pro His Asn
  30                  35                  40                  45

 ttt atg tat agc aaa act gtc aag agg ctg tcc aag tta cga gag tat      193
 Phe Met Tyr Ser Lys Thr Val Lys Arg Leu Ser Lys Leu Arg Glu Tyr
                  50                  55                  60

 caa cag tat cat tca agc ctg acc tgc gtc atg gaa gga aag gac ata      241
 Gln Gln Tyr His Ser Ser Leu Thr Cys Val Met Glu Gly Lys Asp Ile
              65                  70                  75

 gaa gat tgg agc tgc tgc cca acc cct tgg act tca ttt cag tct agt      289
 Glu Asp Trp Ser Cys Cys Pro Thr Pro Trp Thr Ser Phe Gln Ser Ser
          80                  85                  90

 tgc tac ttt att tct act ggg atg caa tct tgg act aag agt caa aag      337
 Cys Tyr Phe Ile Ser Thr Gly Met Gln Ser Trp Thr Lys Ser Gln Lys
      95                 100                 105

 aac tgt tct gtg atg ggg gct gat ctg gtg gtg atc aac acc agg gaa      385
 Asn Cys Ser Val Met Gly Ala Asp Leu Val Val Ile Asn Thr Arg Glu
 110                 115                 120                 125

 gaa cag gat ttc atc att cag aat ctg aaa aga aat tct tct tat ttt      433
 Glu Gln Asp Phe Ile Ile Gln Asn Leu Lys Arg Asn Ser Ser Tyr Phe
                 130                 135                 140

 ctg ggg ctg tca gat cca ggg ggt cgg cga cat tgg caa tgg gtt gac      481
 Leu Gly Leu Ser Asp Pro Gly Gly Arg Arg His Trp Gln Trp Val Asp
             145                 150                 155

 cag aca cca tac aat gaa aat gtc aca ttc tgg cac tca ggt gaa ccc      529
 Gln Thr Pro Tyr Asn Glu Asn Val Thr Phe Trp His Ser Gly Glu Pro
         160                 165                 170

 aat aac ctt gat gag cgt tgt gcg ata ata aat ttc cgt tct tca gaa      577
 Asn Asn Leu Asp Glu Arg Cys Ala Ile Ile Asn Phe Arg Ser Ser Glu
     175                 180                 185

 gaa tgg ggc tgg aat gac att cac tgt cat gta cct cag aag tca att      625
 Glu Trp Gly Trp Asn Asp Ile His Cys His Val Pro Gln Lys Ser Ile
 190                 195                 200                 205

 tgc aag atg aag aag atc tac ata taa atgaa atattctccc tggaaatgtg      677
 Cys Lys Met Lys Lys Ile Tyr Ile 
                 210

 tttgggttgg catccaccgt tgtagaaagc taaattgatt ttttaattta tgtgtaagtt    737

 ttgtacaagg aatgccccta aaatgtttca gcaggctgtc acctattaca cttatgatat    797

 aatccaaaaa aaaaaaaaaa                                                817




      <210> 414
      <211> 1065
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(1065)

      <400> 414
 atgatgaaac agtgtagaca gcctttggaa aaaacccagt acggcttcct aggaacagat     60

 cgtgtagaag agaaaacttc agtgataacc atcagagtta gtgtgaccca cagacacaac    120

 agctac   atg gaa gca gaa aac ctt aca gaa tta tca aaa ttt ctc ctc     168
          Met Glu Ala Glu Asn Leu Thr Glu Leu Ser Lys Phe Leu Leu
            1               5                  10

 ctg gga ctc tca gat gat cct gaa ctg cag ccc gtc ctc ttt ggg ctg      216
 Leu Gly Leu Ser Asp Asp Pro Glu Leu Gln Pro Val Leu Phe Gly Leu
  15                  20                  25                  30

 ttc ctg tcc atg tac ctg gtc acg gtg ctg ggg aac ctg ctc atc att      264
 Phe Leu Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile
                  35                  40                  45

 ctg gcc gtc agc tct gac tcc cac ctc cac acc ccc atg tac ttc ttc      312
 Leu Ala Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe
              50                  55                  60

 ctc tcc aac ctg tcc ttt gtt gac atc tgt ttc atc tcc acc aca gtc      360
 Leu Ser Asn Leu Ser Phe Val Asp Ile Cys Phe Ile Ser Thr Thr Val
          65                  70                  75

 ccc aag atg cta gtg agc atc cag gca cgg agc aaa gac atc tcc tac      408
 Pro Lys Met Leu Val Ser Ile Gln Ala Arg Ser Lys Asp Ile Ser Tyr
      80                  85                  90

 atg ggg tgc ctc act cag gtg tat ttt tta atg atg ttt gct gga atg      456
 Met Gly Cys Leu Thr Gln Val Tyr Phe Leu Met Met Phe Ala Gly Met
  95                 100                 105                 110

 gat act ttc cta ctg gcc gtg atg gcc tat gac cgg ttt gtg gcc atc      504
 Asp Thr Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile
                 115                 120                 125

 tgc cac cca ctg cac tac acg gtc atc atg aac ccc tgc ctc tgt ggc      552
 Cys His Pro Leu His Tyr Thr Val Ile Met Asn Pro Cys Leu Cys Gly
             130                 135                 140

 ctc ctg gtt ctg gca tct tgg ttc atc att ttc tgg ttc tcc ctg gtt      600
 Leu Leu Val Leu Ala Ser Trp Phe Ile Ile Phe Trp Phe Ser Leu Val
         145                 150                 155

 cat att cta ctg atg aag agg ttg acc ttc tcc aca ggc act gag att      648
 His Ile Leu Leu Met Lys Arg Leu Thr Phe Ser Thr Gly Thr Glu Ile
     160                 165                 170

 ccg cat ttc ttc tgt gaa ccg gct cag gtc ctc aag gtg gcc tgc tct      696
 Pro His Phe Phe Cys Glu Pro Ala Gln Val Leu Lys Val Ala Cys Ser
 175                 180                 185                 190

 aac acc ctc ctc aat aac att gtc ttg tat gtg gcc acg gca ctg ctg      744
 Asn Thr Leu Leu Asn Asn Ile Val Leu Tyr Val Ala Thr Ala Leu Leu
                 195                 200                 205

 ggt gtg ttt cct gta gct ggg atc ctc ttc tcc tac tct cag att gtc      792
 Gly Val Phe Pro Val Ala Gly Ile Leu Phe Ser Tyr Ser Gln Ile Val
             210                 215                 220

 tcc tcc tta atg gga atg tcc tcc acc aag ggc aag tac aaa gcc ttt      840
 Ser Ser Leu Met Gly Met Ser Ser Thr Lys Gly Lys Tyr Lys Ala Phe
         225                 230                 235

 tcc acc tgt gga tct cac ctc tgt gtg gtc tcc ttg ttc tat gga aca      888
 Ser Thr Cys Gly Ser His Leu Cys Val Val Ser Leu Phe Tyr Gly Thr
     240                 245                 250

 gga ctt ggg gtc tat ctg agt tct gct gtg acc cat tct tcc cag agc      936
 Gly Leu Gly Val Tyr Leu Ser Ser Ala Val Thr His Ser Ser Gln Ser
 255                 260                 265                 270

 agc tcc acc gcc tca gtg atg tac gcc atg gtc acc ccc atg ctg aac      984
 Ser Ser Thr Ala Ser Val Met Tyr Ala Met Val Thr Pro Met Leu Asn
                 275                 280                 285

 ccc ttc atc tac agc ctg agg aac aag gat gtg aag ggg gcc ctg gaa     1032
 Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Glu
             290                 295                 300

 aga ctc ctc agc agg gcc gac tct tgt cca tga                         1065
 Arg Leu Leu Ser Arg Ala Asp Ser Cys Pro 
         305                 310





      <210> 415
      <211> 2252
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (13)..(1941)

      <400> 415
 tatttatatg tt    atg acc aca ccc tta cct gcc cat ttt act acc tca      48
                  Met Thr Thr Pro Leu Pro Ala His Phe Thr Thr Ser
                    1               5                  10

 ggc cgc att gca gaa tct acc acc ttc tat atc tct cca ggc tca atg       96
 Gly Arg Ile Ala Glu Ser Thr Thr Phe Tyr Ile Ser Pro Gly Ser Met
          15                  20                  25

 gaa aca aca tta gcc agc act acc aca aca cca ggc ctc agt gca aaa      144
 Glu Thr Thr Leu Ala Ser Thr Thr Thr Thr Pro Gly Leu Ser Ala Lys
      30                  35                  40

 tct acc atc ctt tac agt agc tcc aga tca cca gac caa aca ctc tca      192
 Ser Thr Ile Leu Tyr Ser Ser Ser Arg Ser Pro Asp Gln Thr Leu Ser
  45                  50                  55                  60

 cct gcc agc atg aga agc tcc agc atc agt gga gaa ccc acc agc ttg      240
 Pro Ala Ser Met Arg Ser Ser Ser Ile Ser Gly Glu Pro Thr Ser Leu
                  65                  70                  75

 tat agc caa gca gag tca aca cac aca aca gcg ttc cct gcc agc acc      288
 Tyr Ser Gln Ala Glu Ser Thr His Thr Thr Ala Phe Pro Ala Ser Thr
              80                  85                  90

 acc acc tca ggc ctc agt cag gaa tca aca act ttc cac agt aag cca      336
 Thr Thr Ser Gly Leu Ser Gln Glu Ser Thr Thr Phe His Ser Lys Pro
          95                 100                 105

 ggc tca act gag aca aca ctg tcc cct ggc agc atc aca act tca tct      384
 Gly Ser Thr Glu Thr Thr Leu Ser Pro Gly Ser Ile Thr Thr Ser Ser
     110                 115                 120

 ttt gct caa gaa ttt acc acc cct cat agc caa cca ggc tca gct ctg      432
 Phe Ala Gln Glu Phe Thr Thr Pro His Ser Gln Pro Gly Ser Ala Leu
 125                 130                 135                 140

 tca acg gtg tca cct gcc agc acc aca gtg cca ggc ctt agt gag gaa      480
 Ser Thr Val Ser Pro Ala Ser Thr Thr Val Pro Gly Leu Ser Glu Glu
                 145                 150                 155

 tct acc acc ttc tac agc agc cca ggc tca act gaa acc aca gcg ttt      528
 Ser Thr Thr Phe Tyr Ser Ser Pro Gly Ser Thr Glu Thr Thr Ala Phe
             160                 165                 170

 tct cac agc aac aca atg tcc att cat agt caa caa tct aca ccc ttc      576
 Ser His Ser Asn Thr Met Ser Ile His Ser Gln Gln Ser Thr Pro Phe
         175                 180                 185

 cct gac agc cca ggc ttc act cac aca gtg tta cct gcc acc ctc aca      624
 Pro Asp Ser Pro Gly Phe Thr His Thr Val Leu Pro Ala Thr Leu Thr
     190                 195                 200

 acc aca gac att ggt cag gaa tca aca gcc ttc cac agc agc tca gac      672
 Thr Thr Asp Ile Gly Gln Glu Ser Thr Ala Phe His Ser Ser Ser Asp
 205                 210                 215                 220

 gca act gga aca aca ccc tta cct gcc cgc tcc aca gcc tca gac ctt      720
 Ala Thr Gly Thr Thr Pro Leu Pro Ala Arg Ser Thr Ala Ser Asp Leu
                 225                 230                 235

 gtt gga gaa cct aca act ttc tac atc agc cca tcc cct act tac aca      768
 Val Gly Glu Pro Thr Thr Phe Tyr Ile Ser Pro Ser Pro Thr Tyr Thr
             240                 245                 250

 aca ctc ttt cct gcg agt tcc agc aca tca ggc ctc act gag gaa tct      816
 Thr Leu Phe Pro Ala Ser Ser Ser Thr Ser Gly Leu Thr Glu Glu Ser
         255                 260                 265

 acc acc ttc cac acc agt cca agc ttc act tct aca att gtg tct act      864
 Thr Thr Phe His Thr Ser Pro Ser Phe Thr Ser Thr Ile Val Ser Thr
     270                 275                 280

 gaa agc ctg gaa acc tta gca cca ggg ttg tgc cag gaa gga caa att      912
 Glu Ser Leu Glu Thr Leu Ala Pro Gly Leu Cys Gln Glu Gly Gln Ile
 285                 290                 295                 300

 tgg aat gga aaa caa tgc gtc tgt ccc caa ggc tac gtt ggt tac cag      960
 Trp Asn Gly Lys Gln Cys Val Cys Pro Gln Gly Tyr Val Gly Tyr Gln
                 305                 310                 315

 tgc ttg tcc cct ctg gaa tcc ttc cct gta gaa acc ccg gaa aaa ctc     1008
 Cys Leu Ser Pro Leu Glu Ser Phe Pro Val Glu Thr Pro Glu Lys Leu
             320                 325                 330

 aac gcc act tta ggt atg aca gtg aaa gtg act tac aga aat ttc aca     1056
 Asn Ala Thr Leu Gly Met Thr Val Lys Val Thr Tyr Arg Asn Phe Thr
         335                 340                 345

 gaa aag atg aat gac gca tcc tcc cag gaa tac cag aac ttc agt acc     1104
 Glu Lys Met Asn Asp Ala Ser Ser Gln Glu Tyr Gln Asn Phe Ser Thr
     350                 355                 360

 ctc ttc aag aat cgg atg gat gtc gtt ttg aag ggc gac aat ctt cct     1152
 Leu Phe Lys Asn Arg Met Asp Val Val Leu Lys Gly Asp Asn Leu Pro
 365                 370                 375                 380

 cag tat aga ggg gtg aac att cgg aga ttg ctc aac ggt agc atc gtg     1200
 Gln Tyr Arg Gly Val Asn Ile Arg Arg Leu Leu Asn Gly Ser Ile Val
                 385                 390                 395

 gtc aag aac gat gtc atc ctg gag gca gac tac act tta gag tat gag     1248
 Val Lys Asn Asp Val Ile Leu Glu Ala Asp Tyr Thr Leu Glu Tyr Glu
             400                 405                 410

 gaa ctg ttt gaa aac ctg gca gag att gta aag gcc aag att atg aat     1296
 Glu Leu Phe Glu Asn Leu Ala Glu Ile Val Lys Ala Lys Ile Met Asn
         415                 420                 425

 gaa act aga aca act ctt ctt gat cct gat tcc tgc aga aag gcc ata     1344
 Glu Thr Arg Thr Thr Leu Leu Asp Pro Asp Ser Cys Arg Lys Ala Ile
     430                 435                 440

 ctg tgc tat agt gaa gag gac act ttc gtg gat tca tcg gtg act ccg     1392
 Leu Cys Tyr Ser Glu Glu Asp Thr Phe Val Asp Ser Ser Val Thr Pro
 445                 450                 455                 460

 ggc ttt gac ttc cag gag caa tgc acc cag aag gct gcc gaa gga tat     1440
 Gly Phe Asp Phe Gln Glu Gln Cys Thr Gln Lys Ala Ala Glu Gly Tyr
                 465                 470                 475

 acc cag ttc tac tat gtg gat gtc ttg gat ggg aag ctg gcc tgt gtg     1488
 Thr Gln Phe Tyr Tyr Val Asp Val Leu Asp Gly Lys Leu Ala Cys Val
             480                 485                 490

 aac aag tgc acc aaa gga acg aag tcg caa atg aac tgt aac ctg ggc     1536
 Asn Lys Cys Thr Lys Gly Thr Lys Ser Gln Met Asn Cys Asn Leu Gly
         495                 500                 505

 aca tgt cag ctg caa cgc agt ggc ccc cgc tgc ctg tgc cca aat acg     1584
 Thr Cys Gln Leu Gln Arg Ser Gly Pro Arg Cys Leu Cys Pro Asn Thr
     510                 515                 520

 aac aca cac tgg tac tgg gga gag acc tgt gaa ttc aac atc gcc aag     1632
 Asn Thr His Trp Tyr Trp Gly Glu Thr Cys Glu Phe Asn Ile Ala Lys
 525                 530                 535                 540

 agc ctc gtg tat ggg atc gtg ggg gct gtg atg gcg gtg ctg ctg ctc     1680
 Ser Leu Val Tyr Gly Ile Val Gly Ala Val Met Ala Val Leu Leu Leu
                 545                 550                 555

 gca ttg atc atc cta atc atc tta ttc agc cta tcc cag aga aaa cgg     1728
 Ala Leu Ile Ile Leu Ile Ile Leu Phe Ser Leu Ser Gln Arg Lys Arg
             560                 565                 570

 cac agg gaa cag tat gat gtg cct caa gag tgg cga aag gaa ggc acc     1776
 His Arg Glu Gln Tyr Asp Val Pro Gln Glu Trp Arg Lys Glu Gly Thr
         575                 580                 585

 cct ggc atc ttc cag aag acg gcc atc tgg aaa gac cag aat ctg agg     1824
 Pro Gly Ile Phe Gln Lys Thr Ala Ile Trp Lys Asp Gln Asn Leu Arg
     590                 595                 600

 gag agc aga ttc ggc ctt gag aac gcc tac aac aac ttc cgg ccc acc     1872
 Glu Ser Arg Phe Gly Leu Glu Asn Ala Tyr Asn Asn Phe Arg Pro Thr
 605                 610                 615                 620

 ctg gag act gtt gac tct ggc aca gag ctc cac atc cag agg ccg gag     1920
 Leu Glu Thr Val Asp Ser Gly Thr Glu Leu His Ile Gln Arg Pro Glu
                 625                 630                 635

 atg gta gca tcc act gtg tga gc caacgggggc ctcccaccct catctagctc     1973
 Met Val Ala Ser Thr Val 
             640

 tgttcaggag agctgcaaac acagagccca ccacaagcct ccggggcggg tcaagaggag   2033

 accgaagtca ggccctgaag ccggtcctgc tctgagctga cagacttggc cagtcccctg   2093

 cctgtgctcc tgctggggaa ggctgggggc tgtaagcctc tccatccggg agcttccaga   2153

 ctcccagaag cctcggcacc cctgtctcct cctgggtggc tccccactct ggaatttccc   2213

 taccaataaa agcaaatctg aaagctcaaa aaaaaaaaa                          2252




      <210> 416
      <211> 1557
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(1332)

      <400> 416
 ccgagcactg ggacttcaac gccaccatct ccaagactcg gtttggggtg aaag  atg      57
                                                              Met
                                                                1

 gcg ctg act ggg tac agc tgg ctg ctc ctc agt gcc aca ttc ctg aat      105
 Ala Leu Thr Gly Tyr Ser Trp Leu Leu Leu Ser Ala Thr Phe Leu Asn
               5                  10                  15

 gtg ggg gcc gag atc tct atc acc ctg gag cct gcc cag ccg agc gaa      153
 Val Gly Ala Glu Ile Ser Ile Thr Leu Glu Pro Ala Gln Pro Ser Glu
          20                  25                  30

 ggg gac aac gtc acg ctg gtc gtc cat ggg ctt tcg ggg gaa ctg ctc      201
 Gly Asp Asn Val Thr Leu Val Val His Gly Leu Ser Gly Glu Leu Leu
      35                  40                  45

 gcc tac agc tgg tat gcg ggg ccc aca ctc agc gtg tca tac ctg gtg      249
 Ala Tyr Ser Trp Tyr Ala Gly Pro Thr Leu Ser Val Ser Tyr Leu Val
  50                  55                  60                  65

 gcc agc tac atc gtg agc aca ggc gat gag act cct ggc ccg gcc cac      297
 Ala Ser Tyr Ile Val Ser Thr Gly Asp Glu Thr Pro Gly Pro Ala His
                  70                  75                  80

 acg ggg cgg gag gct gtg cgc ccc gat ggc agc ctg gac atc cag ggc      345
 Thr Gly Arg Glu Ala Val Arg Pro Asp Gly Ser Leu Asp Ile Gln Gly
              85                  90                  95

 atc ctg ccc cgg cac tca ggc acc tac atc ctg cag acc ttc aac agg      393
 Ile Leu Pro Arg His Ser Gly Thr Tyr Ile Leu Gln Thr Phe Asn Arg
         100                 105                 110

 cag ttg cag acc gag gtg ggc tac gga cac gtg cag gtc cat gag atc      441
 Gln Leu Gln Thr Glu Val Gly Tyr Gly His Val Gln Val His Glu Ile
     115                 120                 125

 ctg gcc cag ccc aca gtc ttg gcc aac agc aca gcg ctg gtg gaa cgt      489
 Leu Ala Gln Pro Thr Val Leu Ala Asn Ser Thr Ala Leu Val Glu Arg
 130                 135                 140                 145

 cga gac acc ctg cgc ctt atg tgc agc agc ccc agc ccc acc gcc gag      537
 Arg Asp Thr Leu Arg Leu Met Cys Ser Ser Pro Ser Pro Thr Ala Glu
                 150                 155                 160

 gtc cgc tgg ttc ttc aac ggt ggg gcc ctg ccc gtc gct ctc cgc ctg      585
 Val Arg Trp Phe Phe Asn Gly Gly Ala Leu Pro Val Ala Leu Arg Leu
             165                 170                 175

 ggc ctg ttc cct gac ggc cgg gtg ctg gcc agg cat ggc atc cgc cgg      633
 Gly Leu Phe Pro Asp Gly Arg Val Leu Ala Arg His Gly Ile Arg Arg
         180                 185                 190

 gag gag gcc ggc gcc tat cag tgt gag gtg tgg aac ccg gtc agt gtc      681
 Glu Glu Ala Gly Ala Tyr Gln Cys Glu Val Trp Asn Pro Val Ser Val
     195                 200                 205

 agc cgc agc gag ccc atc aac ctg acc gtg tac ttt ggc cca gag cgt      729
 Ser Arg Ser Glu Pro Ile Asn Leu Thr Val Tyr Phe Gly Pro Glu Arg
 210                 215                 220                 225

 gtg gcc atc ctc cag gat tcc acc acc cgc aca ggc tgc acc atc aaa      777
 Val Ala Ile Leu Gln Asp Ser Thr Thr Arg Thr Gly Cys Thr Ile Lys
                 230                 235                 240

 gtt gac ttc aac acg tcc ctc acc ctg tgg tgc gtg tcc agg tcc tgc      825
 Val Asp Phe Asn Thr Ser Leu Thr Leu Trp Cys Val Ser Arg Ser Cys
             245                 250                 255

 cca gag ccc gag tat gtg tgg acc ttc aac ggg cag gcc cta aag aac      873
 Pro Glu Pro Glu Tyr Val Trp Thr Phe Asn Gly Gln Ala Leu Lys Asn
         260                 265                 270

 ggc caa gac cac ctc aac atc agc agc atg aca gcc gcc cag gag ggg      921
 Gly Gln Asp His Leu Asn Ile Ser Ser Met Thr Ala Ala Gln Glu Gly
     275                 280                 285

 acg tac aca tgt att gcg aag aac acc aag acc ctg cta tct gga tct      969
 Thr Tyr Thr Cys Ile Ala Lys Asn Thr Lys Thr Leu Leu Ser Gly Ser
 290                 295                 300                 305

 gcc tca gtc gtg gtc aag ctc tct gct gca gca gtt gcc acg atg atc     1017
 Ala Ser Val Val Val Lys Leu Ser Ala Ala Ala Val Ala Thr Met Ile
                 310                 315                 320

 gtg ccc gtg ccc acc aag cca acg gag ggc cag gac gta aca ctg acc     1065
 Val Pro Val Pro Thr Lys Pro Thr Glu Gly Gln Asp Val Thr Leu Thr
             325                 330                 335

 gtg cag ggc tac ccc aag gac ctg ctg gtc tac gcc tgg tac cgc ggg     1113
 Val Gln Gly Tyr Pro Lys Asp Leu Leu Val Tyr Ala Trp Tyr Arg Gly
         340                 345                 350

 cct gcc tcc gag ccc aac cgg ctg ctc agc cag ctg ccg tca gga acc     1161
 Pro Ala Ser Glu Pro Asn Arg Leu Leu Ser Gln Leu Pro Ser Gly Thr
     355                 360                 365

 tgg att gca ggc ccc gcg cac aca ggc cgg gag gtg ggc ttc ccc aac     1209
 Trp Ile Ala Gly Pro Ala His Thr Gly Arg Glu Val Gly Phe Pro Asn
 370                 375                 380                 385

 tgc tcg ctg ttg gtg cag aag ctg aac ctc aca gac act ggc cgc tac     1257
 Cys Ser Leu Leu Val Gln Lys Leu Asn Leu Thr Asp Thr Gly Arg Tyr
                 390                 395                 400

 aca ctc aag acc gtc aca gtg cag ggc aag act gag aca ctg gaa gtg     1305
 Thr Leu Lys Thr Val Thr Val Gln Gly Lys Thr Glu Thr Leu Glu Val
             405                 410                 415

 gag ctg cag gtg gcc ccc ctg ggg taa cagcg tgaccctgga gacgtccaga     1357
 Glu Leu Gln Val Ala Pro Leu Gly 
         420                 425

 gagaagagct cttcgcacca tcctctggtc ctcgccctct gagtgggaac cactccccca   1417

 cagcgaggat gccaggctgt ggtcctgctg ttctcctgcc tccaccctag agctagagcc   1477

 actagggccc acttcctggg gtgagctgtt ggggagccac cgaggccata aacgtcctgg   1537

 ttaatgcaaa aaaaaaaaaa                                               1557




      <210> 417
      <211> 4842
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (145)..(4536)

      <400> 417
 cagtggtaac aacgcatagt gcgggggctc ccaaacttgg ctcagtccag cagccaccat     60

 caccaccact gcggttgctg ctgcagctgc agctgctgct ctccctccgg ctgcttcttc    120

 gcgtggccag cagcgaatgg agcg   atg gag ccc aga ctg ttc tgc tgg acc     171
                              Met Glu Pro Arg Leu Phe Cys Trp Thr
                                1               5

 act ctc ttt ctc ctg gcc ggg tgg tgc ctg cca ggg ttg ccc tgc ccc      219
 Thr Leu Phe Leu Leu Ala Gly Trp Cys Leu Pro Gly Leu Pro Cys Pro
  10                  15                  20                  25

 agc cgg tgc ctt tgc ttt aag agc acc gtc cgc tgc atg cac ttg atg      267
 Ser Arg Cys Leu Cys Phe Lys Ser Thr Val Arg Cys Met His Leu Met
                  30                  35                  40

 ctg gac cac att cct cag gta cca cag cag acc aca gtt cta gac ttg      315
 Leu Asp His Ile Pro Gln Val Pro Gln Gln Thr Thr Val Leu Asp Leu
              45                  50                  55

 agg ttt aac aga ata aga gaa att cca ggg agc gcc ttc aag aaa ctc      363
 Arg Phe Asn Arg Ile Arg Glu Ile Pro Gly Ser Ala Phe Lys Lys Leu
          60                  65                  70

 aag aat ttg aac aca ctt ctg ctg aac aac aac cac atc aga aag att      411
 Lys Asn Leu Asn Thr Leu Leu Leu Asn Asn Asn His Ile Arg Lys Ile
      75                  80                  85

 tcc aga aat gct ttt gaa gga ctt gaa aat ttg cta tat ctg tac ctg      459
 Ser Arg Asn Ala Phe Glu Gly Leu Glu Asn Leu Leu Tyr Leu Tyr Leu
  90                  95                 100                 105

 tat aag aat gaa atc cat gca cta gat aag caa aca ttt aaa gga ctc      507
 Tyr Lys Asn Glu Ile His Ala Leu Asp Lys Gln Thr Phe Lys Gly Leu
                 110                 115                 120

 ata tct ttg gaa cat ctg tat att cat ttc aac caa cta gaa atg cta      555
 Ile Ser Leu Glu His Leu Tyr Ile His Phe Asn Gln Leu Glu Met Leu
             125                 130                 135

 cag cca gag acc ttt gga gac ctt ctg aga tta gag cga cta ttt ttg      603
 Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg Leu Phe Leu
         140                 145                 150

 cat aac aac aaa tta tct aaa att ccg gct ggg agc ttt tct aat ctg      651
 His Asn Asn Lys Leu Ser Lys Ile Pro Ala Gly Ser Phe Ser Asn Leu
     155                 160                 165

 gat tca tta aaa aga ttg cgt ctg gat tcc aac gcc ctg gtt tgt gac      699
 Asp Ser Leu Lys Arg Leu Arg Leu Asp Ser Asn Ala Leu Val Cys Asp
 170                 175                 180                 185

 tgt gat ctg atg tgg ctg ggg gag ctt tta caa ggc ttt gcc caa cac      747
 Cys Asp Leu Met Trp Leu Gly Glu Leu Leu Gln Gly Phe Ala Gln His
                 190                 195                 200

 ggc cac acc cag gct gcg gct acc tgc gaa tat ccc agg aga ctc cat      795
 Gly His Thr Gln Ala Ala Ala Thr Cys Glu Tyr Pro Arg Arg Leu His
             205                 210                 215

 ggg cgt gca gtt gct tca gta aca gta gag gaa ttc aat tgc cag agc      843
 Gly Arg Ala Val Ala Ser Val Thr Val Glu Glu Phe Asn Cys Gln Ser
         220                 225                 230

 ccc cga att act ttt gag ccg cag gat gtg gag gta cca tca gga aat      891
 Pro Arg Ile Thr Phe Glu Pro Gln Asp Val Glu Val Pro Ser Gly Asn
     235                 240                 245

 acc gtc tac ttc acc tgc cgg gcg gaa gga aac ccc aaa cct gag att      939
 Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys Pro Glu Ile
 250                 255                 260                 265

 att tgg ata cac aac aac cac tca ttg gat ttg gaa gat gat act cga      987
 Ile Trp Ile His Asn Asn His Ser Leu Asp Leu Glu Asp Asp Thr Arg
                 270                 275                 280

 ctt aat gtg ttt gat gat ggc aca ctc atg atc cga aac acc aga gag     1035
 Leu Asn Val Phe Asp Asp Gly Thr Leu Met Ile Arg Asn Thr Arg Glu
             285                 290                 295

 tca gac caa ggt gtc tat cag tgc atg gcc aga aat tcc gct ggg gaa     1083
 Ser Asp Gln Gly Val Tyr Gln Cys Met Ala Arg Asn Ser Ala Gly Glu
         300                 305                 310

 gcc aag aca cag agt gcc atg ctc aga tac tcc agt ctt cca gcc aaa     1131
 Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu Pro Ala Lys
     315                 320                 325

 cca agc ttt gta atc cag cct cag gac aca gag gtt tta att ggc acc     1179
 Pro Ser Phe Val Ile Gln Pro Gln Asp Thr Glu Val Leu Ile Gly Thr
 330                 335                 340                 345

 agc aca act ttg gaa tgt atg gcc aca ggc cac cca cac cct ctt atc     1227
 Ser Thr Thr Leu Glu Cys Met Ala Thr Gly His Pro His Pro Leu Ile
                 350                 355                 360

 act tgg acc agg gac aat gga ttg gag ctg gat gga tcc agg cac gtg     1275
 Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser Arg His Val
             365                 370                 375

 gca acg tcc agt gga ctt tac tta cag aac atc aca caa cgg gat cat     1323
 Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln Arg Asp His
         380                 385                 390

 ggt cga ttt acc tgt cat gcc aac aat agc cac ggc act gtt caa gct     1371
 Gly Arg Phe Thr Cys His Ala Asn Asn Ser His Gly Thr Val Gln Ala
     395                 400                 405

 gca gca aac ata att gta caa gct cct cca caa ttt aca gta acc ccc     1419
 Ala Ala Asn Ile Ile Val Gln Ala Pro Pro Gln Phe Thr Val Thr Pro
 410                 415                 420                 425

 aag gat caa gtg gtg ctg gaa gaa cat gct gta gag tgg ctc tgt gaa     1467
 Lys Asp Gln Val Val Leu Glu Glu His Ala Val Glu Trp Leu Cys Glu
                 430                 435                 440

 gct gac ggc aac cca cct cct gtt att gtc tgg aca aaa aca gga ggg     1515
 Ala Asp Gly Asn Pro Pro Pro Val Ile Val Trp Thr Lys Thr Gly Gly
             445                 450                 455

 cag ctc cct gtg gaa ggc cag cat aca gtt ctc tcc tct ggc act ttg     1563
 Gln Leu Pro Val Glu Gly Gln His Thr Val Leu Ser Ser Gly Thr Leu
         460                 465                 470

 aga att gac cgt gca gca cag cac gat caa ggc caa tat gaa tgt caa     1611
 Arg Ile Asp Arg Ala Ala Gln His Asp Gln Gly Gln Tyr Glu Cys Gln
     475                 480                 485

 gca gtc agt tcg ttg ggg gtg aaa aag gtg tct gtg cag ctg act gta     1659
 Ala Val Ser Ser Leu Gly Val Lys Lys Val Ser Val Gln Leu Thr Val
 490                 495                 500                 505

 aaa ccc aaa gct ctt gca gtg ttt act caa ctt cct cag gat aca agt     1707
 Lys Pro Lys Ala Leu Ala Val Phe Thr Gln Leu Pro Gln Asp Thr Ser
                 510                 515                 520

 gtc gag gtt gga aag aat ata aac att tca tgt cat gct caa gga gaa     1755
 Val Glu Val Gly Lys Asn Ile Asn Ile Ser Cys His Ala Gln Gly Glu
             525                 530                 535

 cca cag ccc ata att act tgg aat aag gaa ggt gtg cag att act gag     1803
 Pro Gln Pro Ile Ile Thr Trp Asn Lys Glu Gly Val Gln Ile Thr Glu
         540                 545                 550

 agt ggt aaa ttc cat gtg gat gat gaa ggc acg ctg act atc tac gac     1851
 Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr Ile Tyr Asp
     555                 560                 565

 gca ggg ttc cct gac cag gga aga tat gaa tgt gtg gct cgg aat tct     1899
 Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala Arg Asn Ser
 570                 575                 580                 585

 ttt ggc ctt gct gtg acc aac atg ttt ctt aca gtc acg gct ata cag     1947
 Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr Ala Ile Gln
                 590                 595                 600

 ggt aga caa gct ggc gat gac ttt gtt gaa tct tcc att ctt gat gct     1995
 Gly Arg Gln Ala Gly Asp Asp Phe Val Glu Ser Ser Ile Leu Asp Ala
             605                 610                 615

 gta cag aga gtt gac agt gca att aac tcc aca cga aga cat ttg ttt     2043
 Val Gln Arg Val Asp Ser Ala Ile Asn Ser Thr Arg Arg His Leu Phe
         620                 625                 630

 tca caa aaa cct cac acc tcc agt gac ctg ctg gct caa ttt cat tac     2091
 Ser Gln Lys Pro His Thr Ser Ser Asp Leu Leu Ala Gln Phe His Tyr
     635                 640                 645

 ccg cgt gac cca ctg att gtg gaa atg gca aga gca ggg gag att ttt     2139
 Pro Arg Asp Pro Leu Ile Val Glu Met Ala Arg Ala Gly Glu Ile Phe
 650                 655                 660                 665

 gag cac acg ctg cag ctg ata cgg gaa cgt gtg aag cag ggg ctc act     2187
 Glu His Thr Leu Gln Leu Ile Arg Glu Arg Val Lys Gln Gly Leu Thr
                 670                 675                 680

 gtg gac ttg gaa ggc aaa gaa ttc cgg tac aat gac ttg gtg tcc ccg     2235
 Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr Asn Asp Leu Val Ser Pro
             685                 690                 695

 cgc tcc ctc agc ctc atc gcc aat tta tct gga tgc aca gct cgc agg     2283
 Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser Gly Cys Thr Ala Arg Arg
         700                 705                 710

 cct ctg cca aac tgc tcc aac cgg tgt ttc cat gcg aag tac cgc gcc     2331
 Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe His Ala Lys Tyr Arg Ala
     715                 720                 725

 cac gac ggc acg tgc aac aac ctg cag cag ccc acg tgg ggc gcg gcg     2379
 His Asp Gly Thr Cys Asn Asn Leu Gln Gln Pro Thr Trp Gly Ala Ala
 730                 735                 740                 745

 ctg acc gcc ttc gcg cgc ctg ctg cag cca gcc tac cgg gac ggc atc     2427
 Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro Ala Tyr Arg Asp Gly Ile
                 750                 755                 760

 cgc gcg ccc cgc ggg ctc ggc ctt cct gtg ggc tcc cgc cag ccc ctc     2475
 Arg Ala Pro Arg Gly Leu Gly Leu Pro Val Gly Ser Arg Gln Pro Leu
             765                 770                 775

 ccg ccg ccc cgg ctg gtc gcc aca gtg tgg gcg cgc gcg gcg gcc gtc     2523
 Pro Pro Pro Arg Leu Val Ala Thr Val Trp Ala Arg Ala Ala Ala Val
         780                 785                 790

 acc ccc gac cac agc tac acg cgc atg ctc atg cac tgg ggc tgg ttt     2571
 Thr Pro Asp His Ser Tyr Thr Arg Met Leu Met His Trp Gly Trp Phe
     795                 800                 805

 cta gag cac gac ttg gac cac aca gtg cct gcg ctg agc aca gcc cgc     2619
 Leu Glu His Asp Leu Asp His Thr Val Pro Ala Leu Ser Thr Ala Arg
 810                 815                 820                 825

 ttc tcg gat ggg cgg ccg tgc agc tcc gtc tgc acc aac gac cct cct     2667
 Phe Ser Asp Gly Arg Pro Cys Ser Ser Val Cys Thr Asn Asp Pro Pro
                 830                 835                 840

 tgt ttc ccc atg aac acc cgg cac gcc gac ccc cgg ggc acc cac gcg     2715
 Cys Phe Pro Met Asn Thr Arg His Ala Asp Pro Arg Gly Thr His Ala
             845                 850                 855

 ccc tgc atg ctc ttc gcg cgc tcc agc ccc gcg tgt gcc agc ggc cgt     2763
 Pro Cys Met Leu Phe Ala Arg Ser Ser Pro Ala Cys Ala Ser Gly Arg
         860                 865                 870

 ccc tct gcg acg gtg gat tca gtc tat gca cga gag cag atc aac cag     2811
 Pro Ser Ala Thr Val Asp Ser Val Tyr Ala Arg Glu Gln Ile Asn Gln
     875                 880                 885

 caa aca gcc tac atc gat ggc tcc aac gtt tac ggg agc tcg gag cgg     2859
 Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val Tyr Gly Ser Ser Glu Arg
 890                 895                 900                 905

 gaa tcc cag gct ctc aga gac cct tcg gtg cct cgg ggt ctc ctg aag     2907
 Glu Ser Gln Ala Leu Arg Asp Pro Ser Val Pro Arg Gly Leu Leu Lys
                 910                 915                 920

 aca ggc ttt cct tgg cct ccc tcc gga aag ccc tta ttg ccc ttt tct     2955
 Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys Pro Leu Leu Pro Phe Ser
             925                 930                 935

 aca ggc cca ccc acc gag tgc gcg cga cag gag cag gag agc ccc tgt     3003
 Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln Glu Gln Glu Ser Pro Cys
         940                 945                 950

 ttc ctg gcc ggg gac cac cgg gcc aac gag cat ctg gct ctg gcc gcc     3051
 Phe Leu Ala Gly Asp His Arg Ala Asn Glu His Leu Ala Leu Ala Ala
     955                 960                 965

 atg cac acc ctg tgg ttc cgg gaa cac aac agg gtg gcc acg gag ctg     3099
 Met His Thr Leu Trp Phe Arg Glu His Asn Arg Val Ala Thr Glu Leu
 970                 975                 980                 985

 tcc gcc ctg aac ccc cac tgg gag gga aac acg gtt tac cag gaa gcc     3147
 Ser Ala Leu Asn Pro His Trp Glu Gly Asn Thr Val Tyr Gln Glu Ala
                 990                 995                1000

 agg aag atc gtg ggc gcg gag ctg cag cac atc acc tac agc cac tgg     3195
 Arg Lys Ile Val Gly Ala Glu Leu Gln His Ile Thr Tyr Ser His Trp
            1005                1010                1015

 ctg cct aag gtc ctg ggg gac cct ggc act agg atg ctg agg ggt tac     3243
 Leu Pro Lys Val Leu Gly Asp Pro Gly Thr Arg Met Leu Arg Gly Tyr
        1020                1025                1030

 cga ggc tac aac ccc aac gtg aat gca ggc atc att aac tct ttt gct     3291
 Arg Gly Tyr Asn Pro Asn Val Asn Ala Gly Ile Ile Asn Ser Phe Ala
    1035                1040                1045

 act gca gcc ttt aga ttt ggc cac aca tta atc aat cct att ctt tac     3339
 Thr Ala Ala Phe Arg Phe Gly His Thr Leu Ile Asn Pro Ile Leu Tyr
1050                1055                1060                1065

 cga ctg aat gcc acc tta ggt gaa att tcc gaa ggc cac ctt ccg ttc     3387
 Arg Leu Asn Ala Thr Leu Gly Glu Ile Ser Glu Gly His Leu Pro Phe
                1070                1075                1080

 cat aaa gcg ctc ttt tca ccg tcc aga ata atc aag gaa ggt ggg ata     3435
 His Lys Ala Leu Phe Ser Pro Ser Arg Ile Ile Lys Glu Gly Gly Ile
            1085                1090                1095

 gac ccg gtt ctc cgg ggg ctg ttt ggc gtg gct gct aaa tgg cgg gca     3483
 Asp Pro Val Leu Arg Gly Leu Phe Gly Val Ala Ala Lys Trp Arg Ala
        1100                1105                1110

 ccc tcc tac ctt ctc agt cct gag ctg acc cag agg ctc ttc tcc gcg     3531
 Pro Ser Tyr Leu Leu Ser Pro Glu Leu Thr Gln Arg Leu Phe Ser Ala
    1115                1120                1125

 gct tat tct gcg gcc gtg gat tcg gct gcc acc atc att caa agg ggt     3579
 Ala Tyr Ser Ala Ala Val Asp Ser Ala Ala Thr Ile Ile Gln Arg Gly
1130                1135                1140                1145

 aga gac cac ggg atc cca cca tat gtt gac ttc aga gtt ttc tgt aat     3627
 Arg Asp His Gly Ile Pro Pro Tyr Val Asp Phe Arg Val Phe Cys Asn
                1150                1155                1160

 ttg act tca gtt aag aac ttt gag gat ctt caa aat gaa att aaa gat     3675
 Leu Thr Ser Val Lys Asn Phe Glu Asp Leu Gln Asn Glu Ile Lys Asp
            1165                1170                1175

 tca gag att aga caa aaa ctg aga aag ttg tac ggc tct cca ggt gac     3723
 Ser Glu Ile Arg Gln Lys Leu Arg Lys Leu Tyr Gly Ser Pro Gly Asp
        1180                1185                1190

 att gac ctc tgg ccc gcc ctt atg gtt gaa gac ctg att cct ggt aca     3771
 Ile Asp Leu Trp Pro Ala Leu Met Val Glu Asp Leu Ile Pro Gly Thr
    1195                1200                1205

 aga gtg gga cca aca ctt atg tgc atg ttc gtt acc cag ttt cag cgg     3819
 Arg Val Gly Pro Thr Leu Met Cys Met Phe Val Thr Gln Phe Gln Arg
1210                1215                1220                1225

 cta aga gat gga gat agg ttc tgg tat gaa aac cct gga gta ttt acc     3867
 Leu Arg Asp Gly Asp Arg Phe Trp Tyr Glu Asn Pro Gly Val Phe Thr
                1230                1235                1240

 ccg gca caa ctc act cag ctg aag cag gcg tcc ctg agc cgg gtg ctt     3915
 Pro Ala Gln Leu Thr Gln Leu Lys Gln Ala Ser Leu Ser Arg Val Leu
            1245                1250                1255

 tgt gac aat ggt gac agc att cag caa gtg cag gct gat gtc ttt gta     3963
 Cys Asp Asn Gly Asp Ser Ile Gln Gln Val Gln Ala Asp Val Phe Val
        1260                1265                1270

 aag gca gaa tac cca cag gat tac ctg aac tgc agc gag atc ccg aag     4011
 Lys Ala Glu Tyr Pro Gln Asp Tyr Leu Asn Cys Ser Glu Ile Pro Lys
    1275                1280                1285

 gtg gac ctg cga gtg tgg caa gac tgc tgt gca gac tgt agg agt aga     4059
 Val Asp Leu Arg Val Trp Gln Asp Cys Cys Ala Asp Cys Arg Ser Arg
1290                1295                1300                1305

 gga cag ttc aga gca gtg acg caa gag tct caa aag aaa cgc tca gct     4107
 Gly Gln Phe Arg Ala Val Thr Gln Glu Ser Gln Lys Lys Arg Ser Ala
                1310                1315                1320

 caa tac agc tat cct gtt gat aag gat atg gag tta agt cat cta aga     4155
 Gln Tyr Ser Tyr Pro Val Asp Lys Asp Met Glu Leu Ser His Leu Arg
            1325                1330                1335

 agt agg caa caa gat aaa ata tat gtg ggt gaa gat gct aga aat gtg     4203
 Ser Arg Gln Gln Asp Lys Ile Tyr Val Gly Glu Asp Ala Arg Asn Val
        1340                1345                1350

 aca gtt ctg gca aaa aca aag ttc tcc caa gat ttc agc acg ttt gca     4251
 Thr Val Leu Ala Lys Thr Lys Phe Ser Gln Asp Phe Ser Thr Phe Ala
    1355                1360                1365

 gcg gaa att cag gaa acc atc aca gca ctc aga gag cag ata aac aag     4299
 Ala Glu Ile Gln Glu Thr Ile Thr Ala Leu Arg Glu Gln Ile Asn Lys
1370                1375                1380                1385

 ctg gag gca cgc ctg agg cag gca ggg tgt aca gat gtt aga ggg gtt     4347
 Leu Glu Ala Arg Leu Arg Gln Ala Gly Cys Thr Asp Val Arg Gly Val
                1390                1395                1400

 cca agg aag gcc gag gag cgc tgg atg aaa gaa gac tgc act cac tgc     4395
 Pro Arg Lys Ala Glu Glu Arg Trp Met Lys Glu Asp Cys Thr His Cys
            1405                1410                1415

 att tgt gag agt ggc cag gtc acc tgt gtg gtg gag att tgt ccc ccg     4443
 Ile Cys Glu Ser Gly Gln Val Thr Cys Val Val Glu Ile Cys Pro Pro
        1420                1425                1430

 gct ccc tgt ccc agt cct gaa ttg gtg aaa gga acc tgc tgt cca gtt     4491
 Ala Pro Cys Pro Ser Pro Glu Leu Val Lys Gly Thr Cys Cys Pro Val
    1435                1440                1445

 tgc aga gac cga gga atg cca agt gat tcc cca gag aag cgc taa taa     4539
 Cys Arg Asp Arg Gly Met Pro Ser Asp Ser Pro Glu Lys Arg 
1450                1455                1460

 aagttttgtg ctgttgagcc ccaaatggga aatttctcag gaagagacat ttaggacttc   4599

 agaactttta acttgtagtc acattgttga tatggaaacc actgacttaa gcaacttagt   4659

 tcatctaatc ttacatatac ttacgatctt ttattttttc attttctaac ataccttgaa   4719

 ataattcaaa actaaaagca ataaagtgca tatgaagtgt ttgatcataa gaaatatttc   4779

 ttactgtaag ctgtcagttt tatatgccac acctggaaat aaaaagaata tcatggaata   4839

 ttt                                                                 4842




      <210> 418
      <211> 4767
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (145)..(4464)

      <400> 418
 cagtggtaac aacgcatagt gcgggggctc ccaaacttgg ctcagtccag cagccaccat     60

 caccaccact gcggttgctg ctgcagctgc agctgctgct ctccctccgg ctgcttcttc    120

 gcgtggccag cagcgaatgg agcg   atg gag ccc aga ctg ttc tgc tgg acc     171
                              Met Glu Pro Arg Leu Phe Cys Trp Thr
                                1               5

 act ctc ttt ctc ctg gcc ggg tgg tgc ctg cca ggg ttg ccc tgc ccc      219
 Thr Leu Phe Leu Leu Ala Gly Trp Cys Leu Pro Gly Leu Pro Cys Pro
  10                  15                  20                  25

 agc cgg tgc ctt tgc ttt aag agc acc gtc cgc tgc atg cac ttg atg      267
 Ser Arg Cys Leu Cys Phe Lys Ser Thr Val Arg Cys Met His Leu Met
                  30                  35                  40

 ctg gac cac att cct cag gta cca cag cag acc aca gtt cta gac ttg      315
 Leu Asp His Ile Pro Gln Val Pro Gln Gln Thr Thr Val Leu Asp Leu
              45                  50                  55

 agg ttt aac aga ata aga gaa att cca ggg agc gcc ttc aag aaa ctc      363
 Arg Phe Asn Arg Ile Arg Glu Ile Pro Gly Ser Ala Phe Lys Lys Leu
          60                  65                  70

 aag aat ttg aac aca ctg tac ctg tat aag aat gaa atc cat gca cta      411
 Lys Asn Leu Asn Thr Leu Tyr Leu Tyr Lys Asn Glu Ile His Ala Leu
      75                  80                  85

 gat aag caa aca ttt aaa gga ctc ata tct ttg gaa cat ctg tat att      459
 Asp Lys Gln Thr Phe Lys Gly Leu Ile Ser Leu Glu His Leu Tyr Ile
  90                  95                 100                 105

 cat ttc aac caa cta gaa atg cta cag cca gag acc ttt gga gac ctt      507
 His Phe Asn Gln Leu Glu Met Leu Gln Pro Glu Thr Phe Gly Asp Leu
                 110                 115                 120

 ctg aga tta gag cga cta ttt ttg cat aac aac aaa tta tct aaa att      555
 Leu Arg Leu Glu Arg Leu Phe Leu His Asn Asn Lys Leu Ser Lys Ile
             125                 130                 135

 ccg gct ggg agc ttt tct aat ctg gat tca tta aaa aga ttg cgt ctg      603
 Pro Ala Gly Ser Phe Ser Asn Leu Asp Ser Leu Lys Arg Leu Arg Leu
         140                 145                 150

 gat tcc aac gcc ctg gtt tgt gac tgt gat ctg atg tgg ctg ggg gag      651
 Asp Ser Asn Ala Leu Val Cys Asp Cys Asp Leu Met Trp Leu Gly Glu
     155                 160                 165

 ctt tta caa ggc ttt gcc caa cac ggc cac acc cag gct gcg gct acc      699
 Leu Leu Gln Gly Phe Ala Gln His Gly His Thr Gln Ala Ala Ala Thr
 170                 175                 180                 185

 tgc gaa tat ccc agg aga ctc cat ggg cgt gca gtt gct tca gta aca      747
 Cys Glu Tyr Pro Arg Arg Leu His Gly Arg Ala Val Ala Ser Val Thr
                 190                 195                 200

 gta gag gaa ttc aat tgc cag agc ccc cga att act ttt gag ccg cag      795
 Val Glu Glu Phe Asn Cys Gln Ser Pro Arg Ile Thr Phe Glu Pro Gln
             205                 210                 215

 gat gtg gag gta cca tca gga aat acc gtc tac ttc acc tgc cgg gcg      843
 Asp Val Glu Val Pro Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala
         220                 225                 230

 gaa gga aac ccc aaa cct gag att att tgg ata cac aac aac cac tca      891
 Glu Gly Asn Pro Lys Pro Glu Ile Ile Trp Ile His Asn Asn His Ser
     235                 240                 245

 ttg gat ttg gaa gat gat act cga ctt aat gtg ttt gat gat ggc aca      939
 Leu Asp Leu Glu Asp Asp Thr Arg Leu Asn Val Phe Asp Asp Gly Thr
 250                 255                 260                 265

 ctc atg atc cga aac acc aga gag tca gac caa ggt gtc tat cag tgc      987
 Leu Met Ile Arg Asn Thr Arg Glu Ser Asp Gln Gly Val Tyr Gln Cys
                 270                 275                 280

 atg gcc aga aat tcc gct ggg gaa gcc aag aca cag agt gcc atg ctc     1035
 Met Ala Arg Asn Ser Ala Gly Glu Ala Lys Thr Gln Ser Ala Met Leu
             285                 290                 295

 aga tac tcc agt ctt cca gcc aaa cca agc ttt gta atc cag cct cag     1083
 Arg Tyr Ser Ser Leu Pro Ala Lys Pro Ser Phe Val Ile Gln Pro Gln
         300                 305                 310

 gac aca gag gtt tta att ggc acc agc aca act ttg gaa tgt atg gcc     1131
 Asp Thr Glu Val Leu Ile Gly Thr Ser Thr Thr Leu Glu Cys Met Ala
     315                 320                 325

 aca ggc cac cca cac cct ctt atc act tgg acc agg gac aat gga ttg     1179
 Thr Gly His Pro His Pro Leu Ile Thr Trp Thr Arg Asp Asn Gly Leu
 330                 335                 340                 345

 gag ctg gat gga tcc agg cac gtg gca acg tcc agt gga ctt tac tta     1227
 Glu Leu Asp Gly Ser Arg His Val Ala Thr Ser Ser Gly Leu Tyr Leu
                 350                 355                 360

 cag aac atc aca caa cgg gat cat ggt cga ttt acc tgt cat gcc aac     1275
 Gln Asn Ile Thr Gln Arg Asp His Gly Arg Phe Thr Cys His Ala Asn
             365                 370                 375

 aat agc cac ggc act gtt caa gct gca gca aac ata att gta caa gct     1323
 Asn Ser His Gly Thr Val Gln Ala Ala Ala Asn Ile Ile Val Gln Ala
         380                 385                 390

 cct cca caa ttt aca gta acc ccc aag gat caa gtg gtg ctg gaa gaa     1371
 Pro Pro Gln Phe Thr Val Thr Pro Lys Asp Gln Val Val Leu Glu Glu
     395                 400                 405

 cat gct gta gag tgg ctc tgt gaa gct gac ggc aac cca cct cct gtt     1419
 His Ala Val Glu Trp Leu Cys Glu Ala Asp Gly Asn Pro Pro Pro Val
 410                 415                 420                 425

 att gtc tgg aca aaa aca gga ggg cag ctc cct gtg gaa ggc cag cat     1467
 Ile Val Trp Thr Lys Thr Gly Gly Gln Leu Pro Val Glu Gly Gln His
                 430                 435                 440

 aca gtt ctc tcc tct ggc act ttg aga att gac cgt gca gca cag cac     1515
 Thr Val Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala Gln His
             445                 450                 455

 gat caa ggc caa tat gaa tgt caa gca gtc agt tcg ttg ggg gtg aaa     1563
 Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly Val Lys
         460                 465                 470

 aag gtg tct gtg cag ctg act gta aaa ccc aaa gct ctt gca gtg ttt     1611
 Lys Val Ser Val Gln Leu Thr Val Lys Pro Lys Ala Leu Ala Val Phe
     475                 480                 485

 act caa ctt cct cag gat aca agt gtc gag gtt gga aag aat ata aac     1659
 Thr Gln Leu Pro Gln Asp Thr Ser Val Glu Val Gly Lys Asn Ile Asn
 490                 495                 500                 505

 att tca tgt cat gct caa gga gaa cca cag ccc ata att act tgg aat     1707
 Ile Ser Cys His Ala Gln Gly Glu Pro Gln Pro Ile Ile Thr Trp Asn
                 510                 515                 520

 aag gaa ggt gtg cag att act gag agt ggt aaa ttc cat gtg gat gat     1755
 Lys Glu Gly Val Gln Ile Thr Glu Ser Gly Lys Phe His Val Asp Asp
             525                 530                 535

 gaa ggc acg ctg act atc tac gac gca ggg ttc cct gac cag gga aga     1803
 Glu Gly Thr Leu Thr Ile Tyr Asp Ala Gly Phe Pro Asp Gln Gly Arg
         540                 545                 550

 tat gaa tgt gtg gct cgg aat tct ttt ggc ctt gct gtg acc aac atg     1851
 Tyr Glu Cys Val Ala Arg Asn Ser Phe Gly Leu Ala Val Thr Asn Met
     555                 560                 565

 ttt ctt aca gtc acg gct ata cag ggt aga caa gct ggc gat gac ttt     1899
 Phe Leu Thr Val Thr Ala Ile Gln Gly Arg Gln Ala Gly Asp Asp Phe
 570                 575                 580                 585

 gtt gaa tct tcc att ctt gat gct gta cag aga gtt gac agt gca att     1947
 Val Glu Ser Ser Ile Leu Asp Ala Val Gln Arg Val Asp Ser Ala Ile
                 590                 595                 600

 aac tcc aca cga aga cat ttg ttt tca caa aaa cct cac acc tcc agt     1995
 Asn Ser Thr Arg Arg His Leu Phe Ser Gln Lys Pro His Thr Ser Ser
             605                 610                 615

 gac ctg ctg gct caa ttt cat tac ccg cgt gac cca ctg att gtg gaa     2043
 Asp Leu Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile Val Glu
         620                 625                 630

 atg gca aga gca ggg gag att ttt gag cac acg ctg cag ctg ata cgg     2091
 Met Ala Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu Ile Arg
     635                 640                 645

 gaa cgt gtg aag cag ggg ctc act gtg gac ttg gaa ggc aaa gaa ttc     2139
 Glu Arg Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys Glu Phe
 650                 655                 660                 665

 cgg tac aat gac ttg gtg tcc ccg cgc tcc ctc agc ctc atc gcc aat     2187
 Arg Tyr Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile Ala Asn
                 670                 675                 680

 tta tct gga tgc aca gct cgc agg cct ctg cca aac tgc tcc aac cgg     2235
 Leu Ser Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn Arg
             685                 690                 695

 tgt ttc cat gcg aag tac cgc gcc cac gac ggc acg tgc aac aac ctg     2283
 Cys Phe His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn Asn Leu
         700                 705                 710

 cag cag ccc acg tgg ggc gcg gcg ctg acc gcc ttc gcg cgc ctg ctg     2331
 Gln Gln Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu Leu
     715                 720                 725

 cag cca gcc tac cgg gac ggc atc cgc gcg ccc cgc ggg ctc ggc ctt     2379
 Gln Pro Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly Leu
 730                 735                 740                 745

 cct gtg ggc tcc cgc cag ccc ctc ccg ccg ccc cgg ctg gtc gcc aca     2427
 Pro Val Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val Ala Thr
                 750                 755                 760

 gtg tgg gcg cgc gcg gcg gcc gtc acc ccc gac cac agc tac acg cgc     2475
 Val Trp Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr Thr Arg
             765                 770                 775

 atg ctc atg cac tgg ggc tgg ttt cta gag cac gac ttg gac cac aca     2523
 Met Leu Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp His Thr
         780                 785                 790

 gtg cct gcg ctg agc aca gcc cgc ttc tcg gat ggg cgg ccg tgc agc     2571
 Val Pro Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys Ser
     795                 800                 805

 tcc gtc tgc acc aac gac cct cct tgt ttc ccc atg aac acc cgg cac     2619
 Ser Val Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr Arg His
 810                 815                 820                 825

 gcc gac ccc cgg ggc acc cac gcg ccc tgc atg ctc ttc gcg cgc tcc     2667
 Ala Asp Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala Arg Ser
                 830                 835                 840

 agc ccc gcg tgt gcc agc ggc cgt ccc tct gcg acg gtg gat tca gtc     2715
 Ser Pro Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp Ser Val
             845                 850                 855

 tat gca cga gag cag atc aac cag caa aca gcc tac atc gat ggc tcc     2763
 Tyr Ala Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly Ser
         860                 865                 870

 aac gtt tac ggg agc tcg gag cgg gaa tcc cag gct ctc aga gac cct     2811
 Asn Val Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp Pro
     875                 880                 885

 tcg gtg cct cgg ggt ctc ctg aag aca ggc ttt cct tgg cct ccc tcc     2859
 Ser Val Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro Pro Ser
 890                 895                 900                 905

 gga aag ccc tta ttg ccc ttt tct aca ggc cca ccc acc gag tgc gcg     2907
 Gly Lys Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu Cys Ala
                 910                 915                 920

 cga cag gag cag gag agc ccc tgt ttc ctg gcc ggg gac cac cgg gcc     2955
 Arg Gln Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His Arg Ala
             925                 930                 935

 aac gag cat ctg gct ctg gcc gcc atg cac acc ctg tgg ttc cgg gaa     3003
 Asn Glu His Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe Arg Glu
         940                 945                 950

 cac aac agg gtg gcc acg gag ctg tcc gcc ctg aac ccc cac tgg gag     3051
 His Asn Arg Val Ala Thr Glu Leu Ser Ala Leu Asn Pro His Trp Glu
     955                 960                 965

 gga aac acg gtt tac cag gaa gcc agg aag atc gtg ggc gcg gag ctg     3099
 Gly Asn Thr Val Tyr Gln Glu Ala Arg Lys Ile Val Gly Ala Glu Leu
 970                 975                 980                 985

 cag cac atc acc tac agc cac tgg ctg cct aag gtc ctg ggg gac cct     3147
 Gln His Ile Thr Tyr Ser His Trp Leu Pro Lys Val Leu Gly Asp Pro
                 990                 995                1000

 ggc act agg atg ctg agg ggt tac cga ggc tac aac ccc aac gtg aat     3195
 Gly Thr Arg Met Leu Arg Gly Tyr Arg Gly Tyr Asn Pro Asn Val Asn
            1005                1010                1015

 gca ggc atc att aac tct ttt gct act gca gcc ttt aga ttt ggc cac     3243
 Ala Gly Ile Ile Asn Ser Phe Ala Thr Ala Ala Phe Arg Phe Gly His
        1020                1025                1030

 aca tta atc aat cct att ctt tac cga ctg aat gcc acc tta ggt gaa     3291
 Thr Leu Ile Asn Pro Ile Leu Tyr Arg Leu Asn Ala Thr Leu Gly Glu
    1035                1040                1045

 att tcc gaa ggc cac ctt ccg ttc cat aaa gcg ctc ttt tca ccg tcc     3339
 Ile Ser Glu Gly His Leu Pro Phe His Lys Ala Leu Phe Ser Pro Ser
1050                1055                1060                1065

 aga ata atc aag gaa ggt ggg ata gac ccg gtt ctc cgg ggg ctg ttt     3387
 Arg Ile Ile Lys Glu Gly Gly Ile Asp Pro Val Leu Arg Gly Leu Phe
                1070                1075                1080

 ggc gtg gct gct aaa tgg cgg gca ccc tcc tac ctt ctc agt cct gag     3435
 Gly Val Ala Ala Lys Trp Arg Ala Pro Ser Tyr Leu Leu Ser Pro Glu
            1085                1090                1095

 ctg acc cag agg ctc ttc tcc gcg gct tat tct gcg gcc gtg gat tcg     3483
 Leu Thr Gln Arg Leu Phe Ser Ala Ala Tyr Ser Ala Ala Val Asp Ser
        1100                1105                1110

 gct gcc acc atc att caa agg ggt aga gac cac ggg atc cca cca tat     3531
 Ala Ala Thr Ile Ile Gln Arg Gly Arg Asp His Gly Ile Pro Pro Tyr
    1115                1120                1125

 gtt gac ttc aga gtt ttc tgt aat ttg act tca gtt aag aac ttt gag     3579
 Val Asp Phe Arg Val Phe Cys Asn Leu Thr Ser Val Lys Asn Phe Glu
1130                1135                1140                1145

 gat ctt caa aat gaa att aaa gat tca gag att aga caa aaa ctg aga     3627
 Asp Leu Gln Asn Glu Ile Lys Asp Ser Glu Ile Arg Gln Lys Leu Arg
                1150                1155                1160

 aag ttg tac ggc tct cca ggt gac att gac ctc tgg ccc gcc ctt atg     3675
 Lys Leu Tyr Gly Ser Pro Gly Asp Ile Asp Leu Trp Pro Ala Leu Met
            1165                1170                1175

 gtt gaa gac ctg att cct ggt aca aga gtg gga cca aca ctt atg tgc     3723
 Val Glu Asp Leu Ile Pro Gly Thr Arg Val Gly Pro Thr Leu Met Cys
        1180                1185                1190

 atg ttc gtt acc cag ttt cag cgg cta aga gat gga gat agg ttc tgg     3771
 Met Phe Val Thr Gln Phe Gln Arg Leu Arg Asp Gly Asp Arg Phe Trp
    1195                1200                1205

 tat gaa aac cct gga gta ttt acc ccg gca caa ctc act cag ctg aag     3819
 Tyr Glu Asn Pro Gly Val Phe Thr Pro Ala Gln Leu Thr Gln Leu Lys
1210                1215                1220                1225

 cag gcg tcc ctg agc cgg gtg ctt tgt gac aat ggt gac agc att cag     3867
 Gln Ala Ser Leu Ser Arg Val Leu Cys Asp Asn Gly Asp Ser Ile Gln
                1230                1235                1240

 caa gtg cag gct gat gtc ttt gta aag gca gaa tac cca cag gat tac     3915
 Gln Val Gln Ala Asp Val Phe Val Lys Ala Glu Tyr Pro Gln Asp Tyr
            1245                1250                1255

 ctg aac tgc agc gag atc ccg aag gtg gac ctg cga gtg tgg caa gac     3963
 Leu Asn Cys Ser Glu Ile Pro Lys Val Asp Leu Arg Val Trp Gln Asp
        1260                1265                1270

 tgc tgt gca gac tgt agg agt aga gga cag ttc aga gca gtg acg caa     4011
 Cys Cys Ala Asp Cys Arg Ser Arg Gly Gln Phe Arg Ala Val Thr Gln
    1275                1280                1285

 gag tct caa aag aaa cgc tca gct caa tac agc tat cct gtt gat aag     4059
 Glu Ser Gln Lys Lys Arg Ser Ala Gln Tyr Ser Tyr Pro Val Asp Lys
1290                1295                1300                1305

 gat atg gag tta agt cat cta aga agt agg caa caa gat aaa ata tat     4107
 Asp Met Glu Leu Ser His Leu Arg Ser Arg Gln Gln Asp Lys Ile Tyr
                1310                1315                1320

 gtg ggt gaa gat gct aga aat gtg aca gtt ctg gca aaa aca aag ttc     4155
 Val Gly Glu Asp Ala Arg Asn Val Thr Val Leu Ala Lys Thr Lys Phe
            1325                1330                1335

 tcc caa gat ttc agc acg ttt gca gcg gaa att cag gaa acc atc aca     4203
 Ser Gln Asp Phe Ser Thr Phe Ala Ala Glu Ile Gln Glu Thr Ile Thr
        1340                1345                1350

 gca ctc aga gag cag ata aac aag ctg gag gca cgc ctg agg cag gca     4251
 Ala Leu Arg Glu Gln Ile Asn Lys Leu Glu Ala Arg Leu Arg Gln Ala
    1355                1360                1365

 ggg tgt aca gat gtt aga ggg gtt cca agg aag gcc gag gag cgc tgg     4299
 Gly Cys Thr Asp Val Arg Gly Val Pro Arg Lys Ala Glu Glu Arg Trp
1370                1375                1380                1385

 atg aaa gaa gac tgc act cac tgc att tgt gag agt ggc cag gtc acc     4347
 Met Lys Glu Asp Cys Thr His Cys Ile Cys Glu Ser Gly Gln Val Thr
                1390                1395                1400

 tgt gtg gtg gag att tgt ccc ccg gct ccc tgt ccc agt cct gaa ttg     4395
 Cys Val Val Glu Ile Cys Pro Pro Ala Pro Cys Pro Ser Pro Glu Leu
            1405                1410                1415

 gtg aaa gga acc tgc tgt cca gtt tgc aga gac cga gga atg cca agt     4443
 Val Lys Gly Thr Cys Cys Pro Val Cys Arg Asp Arg Gly Met Pro Ser
        1420                1425                1430

 gat tcc cca gag aag cgc taa ta aaagttttgt gctgttgagc cccaaatggg     4496
 Asp Ser Pro Glu Lys Arg 
    1435

 aaatttctca ggaagagaca tttaggactt cagaactttt aacttgtagt cacattgttg   4556

 atatggaaac cactgactta agcaacttag ttcatctaat cttacatata cttacgatct   4616

 tttatttttt cattttctaa cataccttga aataattcaa aactaaaagc aataaagtgc   4676

 atatgaagtg tttgatcata agaaatattt cttactgtaa gctgtcagtt ttatatgcca   4736

 cacctggaaa taaaaagaat atcatggaat a                                  4767




      <210> 419
      <211> 3796
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (200)..(3796)

      <400> 419
 tgtatcacag gaaaggtcag tttcctggca tcacatttca aaaccacatc attaggcgat     60

 gacctagaca agctgctgga aaaaatgcaa caaagaagag gagacagtgt ggttacccct    120

 ttcgatggag accttaatga atgtgtgtca ccccaggagg ctgctgctat gattcccaca    180

 caaaacctgg atttagata atg aaa cct tcc aca ttt atc aac cgc agc aac     232
                      Met Lys Pro Ser Thr Phe Ile Asn Arg Ser Asn
                        1               5                  10

 agt tgc cag aaa act ctt atc cca ggt gtg tgc tat agc gga cag tgg      280
 Ser Cys Gln Lys Thr Leu Ile Pro Gly Val Cys Tyr Ser Gly Gln Trp
              15                  20                  25

 cag cca gag cct gga cct cgg tca ctt cag caa agt aga ctt cat cat      328
 Gln Pro Glu Pro Gly Pro Arg Ser Leu Gln Gln Ser Arg Leu His His
          30                  35                  40

 cat tgt tcc cag atc gga ggt gtt ggt tca gca aac tct tca gcg gat      376
 His Cys Ser Gln Ile Gly Gly Val Gly Ser Ala Asn Ser Ser Ala Asp
      45                  50                  55

 tcg aca atc agt gtc att tca ggc tct ttg tca cat agc gaa ccc agt      424
 Ser Thr Ile Ser Val Ile Ser Gly Ser Leu Ser His Ser Glu Pro Ser
  60                  65                  70                  75

 cat ggg cta gct gat aga gtc att aat tgc aga gaa gtt ctg gaa gct      472
 His Gly Leu Ala Asp Arg Val Ile Asn Cys Arg Glu Val Leu Glu Ala
                  80                  85                  90

 ttc aac ctc ctg gtg ctc cag gtc agc tcc ttc cca tac act ctg cag      520
 Phe Asn Leu Leu Val Leu Gln Val Ser Ser Phe Pro Tyr Thr Leu Gln
              95                 100                 105

 acc caa cag tcc cgc att agc tct agc aat gag gtt cac tgg ata cag      568
 Thr Gln Gln Ser Arg Ile Ser Ser Ser Asn Glu Val His Trp Ile Gln
         110                 115                 120

 ctg gat act ggg gag gac gtg ggc tgc gag gag aag ctg tac ttt ggc      616
 Leu Asp Thr Gly Glu Asp Val Gly Cys Glu Glu Lys Leu Tyr Phe Gly
     125                 130                 135

 ttg agt gag tac agc aag tct ctg cag tgg ggg atc acg agc cca ctt      664
 Leu Ser Glu Tyr Ser Lys Ser Leu Gln Trp Gly Ile Thr Ser Pro Leu
 140                 145                 150                 155

 ctg aga tgt gac gag act ttt gaa aaa atg gtg aac aca ctc ttg gag      712
 Leu Arg Cys Asp Glu Thr Phe Glu Lys Met Val Asn Thr Leu Leu Glu
                 160                 165                 170

 agg tac ccc agg ctg cac agc atg gtc gtc cgc tgc tat ctt ctc atc      760
 Arg Tyr Pro Arg Leu His Ser Met Val Val Arg Cys Tyr Leu Leu Ile
             175                 180                 185

 cag cag tac tct gag gcc ctg atg gct ctc acc acc atg gcg tca ctc      808
 Gln Gln Tyr Ser Glu Ala Leu Met Ala Leu Thr Thr Met Ala Ser Leu
         190                 195                 200

 cgc gac cac agc aca cca gaa aca ctc agc att atg gat gac ctc atc      856
 Arg Asp His Ser Thr Pro Glu Thr Leu Ser Ile Met Asp Asp Leu Ile
     205                 210                 215

 agc tcc cca ggc aaa aac aaa agt ggg agg gga cat atg ctc att atc      904
 Ser Ser Pro Gly Lys Asn Lys Ser Gly Arg Gly His Met Leu Ile Ile
 220                 225                 230                 235

 agg gtg ccc tcg gtg cag ctg gcg atg tta gcc aag gag cgg cta cag      952
 Arg Val Pro Ser Val Gln Leu Ala Met Leu Ala Lys Glu Arg Leu Gln
                 240                 245                 250

 gag gtg cgc gac aaa ctg ggt ctg cag tat cgg ttt gag atc atc ctt     1000
 Glu Val Arg Asp Lys Leu Gly Leu Gln Tyr Arg Phe Glu Ile Ile Leu
             255                 260                 265

 ggg aac ccg gcc acc gaa ctc agt gtt gca act cac ttt gtg gcg cga     1048
 Gly Asn Pro Ala Thr Glu Leu Ser Val Ala Thr His Phe Val Ala Arg
         270                 275                 280

 tta aag agt tgg aga gga aat gaa cca gaa gag tgg atc cct cgg aca     1096
 Leu Lys Ser Trp Arg Gly Asn Glu Pro Glu Glu Trp Ile Pro Arg Thr
     285                 290                 295

 tac caa gat tta gac ggt cta cct tgt att gtg ata tta act ggc aaa     1144
 Tyr Gln Asp Leu Asp Gly Leu Pro Cys Ile Val Ile Leu Thr Gly Lys
 300                 305                 310                 315

 gat cct ctt gga gaa acc ttt ccc agg tct ttg aag tac tgt gac ctc     1192
 Asp Pro Leu Gly Glu Thr Phe Pro Arg Ser Leu Lys Tyr Cys Asp Leu
                 320                 325                 330

 cgg tta att gac tca agc tat tta act cgc acg gcc ttg gag cag gag     1240
 Arg Leu Ile Asp Ser Ser Tyr Leu Thr Arg Thr Ala Leu Glu Gln Glu
             335                 340                 345

 gtg ggt ctg gca tgc tgc tat gtc tca aaa gag gtc atc cgg gga ccc     1288
 Val Gly Leu Ala Cys Cys Tyr Val Ser Lys Glu Val Ile Arg Gly Pro
         350                 355                 360

 act gtt gcc ctg gac ctc agc ggg aag gag cag gag aga gct gct gtc     1336
 Thr Val Ala Leu Asp Leu Ser Gly Lys Glu Gln Glu Arg Ala Ala Val
     365                 370                 375

 agt gag aat gac tcc gat gag ctg ctc atc gac ctg gag cgg ccc cag     1384
 Ser Glu Asn Asp Ser Asp Glu Leu Leu Ile Asp Leu Glu Arg Pro Gln
 380                 385                 390                 395

 agc aac agc agc gct gtc aca ggg acc tcg ggt tcc atc atg gag aat     1432
 Ser Asn Ser Ser Ala Val Thr Gly Thr Ser Gly Ser Ile Met Glu Asn
                 400                 405                 410

 gga gtg agc tct tcc aac aca gct gac aag tcc cag aag cag tcc ctg     1480
 Gly Val Ser Ser Ser Asn Thr Ala Asp Lys Ser Gln Lys Gln Ser Leu
             415                 420                 425

 acc ccc agc ttt cag agc cca gcc acc agc ttg ggg ctg gat gaa ggg     1528
 Thr Pro Ser Phe Gln Ser Pro Ala Thr Ser Leu Gly Leu Asp Glu Gly
         430                 435                 440

 gtc tcc gcc agc tca gct gga gcc gga gcc ggg gag act ctg aag cag     1576
 Val Ser Ala Ser Ser Ala Gly Ala Gly Ala Gly Glu Thr Leu Lys Gln
     445                 450                 455

 gag tgt gac tcc ctg ggc ccc cag atg gcg agc agc acc acc tcc aag     1624
 Glu Cys Asp Ser Leu Gly Pro Gln Met Ala Ser Ser Thr Thr Ser Lys
 460                 465                 470                 475

 ccg tca tca tca tcc tca gga ccc agg acc ctc cca tgg ccg gga cag     1672
 Pro Ser Ser Ser Ser Ser Gly Pro Arg Thr Leu Pro Trp Pro Gly Gln
                 480                 485                 490

 ccc atc aga ggc tgc cgg ggc cca cag gca gcc ctg cca cca gtg gtg     1720
 Pro Ile Arg Gly Cys Arg Gly Pro Gln Ala Ala Leu Pro Pro Val Val
             495                 500                 505

 atc cta tcc aaa gcg gcc tac agt ctc ctg ggc tcc cag aag agt ggc     1768
 Ile Leu Ser Lys Ala Ala Tyr Ser Leu Leu Gly Ser Gln Lys Ser Gly
         510                 515                 520

 aag ctg cca tcc tcc tcc tcc ctg ctg ccc cac gcc gac gtg gcc tgg     1816
 Lys Leu Pro Ser Ser Ser Ser Leu Leu Pro His Ala Asp Val Ala Trp
     525                 530                 535

 gtg agc tcc ctg cgg cca ctc ctg aac aag gac atg agc agt gag gag     1864
 Val Ser Ser Leu Arg Pro Leu Leu Asn Lys Asp Met Ser Ser Glu Glu
 540                 545                 550                 555

 cag tcc ctc tac tac agg cag tgg acc ttg gcc cgg cag cac cac gct     1912
 Gln Ser Leu Tyr Tyr Arg Gln Trp Thr Leu Ala Arg Gln His His Ala
                 560                 565                 570

 gac tat agc aac cag ctg gac ccg gcc tct ggc acc cga aac ttc ctc     1960
 Asp Tyr Ser Asn Gln Leu Asp Pro Ala Ser Gly Thr Arg Asn Phe Leu
             575                 580                 585

 ccc cga cgg ctc ctg ctg aca ggg ccc cca cag gtg gga aag acg ggc     2008
 Pro Arg Arg Leu Leu Leu Thr Gly Pro Pro Gln Val Gly Lys Thr Gly
         590                 595                 600

 tcc tat tta cag ttc ctc agg atc ctc ttc cgc atg ctc atc agg ctc     2056
 Ser Tyr Leu Gln Phe Leu Arg Ile Leu Phe Arg Met Leu Ile Arg Leu
     605                 610                 615

 ctg gag gtg gac gtg tat gat gag gag gag atc aac acc gat cac aat     2104
 Leu Glu Val Asp Val Tyr Asp Glu Glu Glu Ile Asn Thr Asp His Asn
 620                 625                 630                 635

 gaa agc agt gaa gtg agc cag tca gag gga gag ccc tgg cct gac atc     2152
 Glu Ser Ser Glu Val Ser Gln Ser Glu Gly Glu Pro Trp Pro Asp Ile
                 640                 645                 650

 gag agc ttc agt aaa atg cct ttt gat gtc agt gtg cat gac ccc aag     2200
 Glu Ser Phe Ser Lys Met Pro Phe Asp Val Ser Val His Asp Pro Lys
             655                 660                 665

 tac agt ttg atg agc ctg gtg tat act gag aag ctg gca ggg gtc aaa     2248
 Tyr Ser Leu Met Ser Leu Val Tyr Thr Glu Lys Leu Ala Gly Val Lys
         670                 675                 680

 caa gaa gtg ata aag gaa tcc aaa gtt gaa gag ccc agg aaa cgg gaa     2296
 Gln Glu Val Ile Lys Glu Ser Lys Val Glu Glu Pro Arg Lys Arg Glu
     685                 690                 695

 act gta tcc ata atg ctg acc aaa tat gca gcc tat aac acc ttt cac     2344
 Thr Val Ser Ile Met Leu Thr Lys Tyr Ala Ala Tyr Asn Thr Phe His
 700                 705                 710                 715

 cac tgt gaa cag tgc cgc cag tac atg gac ttc acc tct gcc tcc cag     2392
 His Cys Glu Gln Cys Arg Gln Tyr Met Asp Phe Thr Ser Ala Ser Gln
                 720                 725                 730

 atg tct gac tcc acc ctt cat gcc ttc aca ttc tct tct tct atg ctg     2440
 Met Ser Asp Ser Thr Leu His Ala Phe Thr Phe Ser Ser Ser Met Leu
             735                 740                 745

 gga gaa gag gtt cag ctc tat ttc atc att ccc aaa tcc aaa gag agt     2488
 Gly Glu Glu Val Gln Leu Tyr Phe Ile Ile Pro Lys Ser Lys Glu Ser
         750                 755                 760

 cat ttt gtc ttc agc aag cag ggc aag cac ctg gag agc atg cgg ctg     2536
 His Phe Val Phe Ser Lys Gln Gly Lys His Leu Glu Ser Met Arg Leu
     765                 770                 775

 ccc ctg gtt tca gac aag aat ttg aat gca gtc aag agc cct att ttc     2584
 Pro Leu Val Ser Asp Lys Asn Leu Asn Ala Val Lys Ser Pro Ile Phe
 780                 785                 790                 795

 act cct tcc agt ggt cga cat gag cac gga ctc cta aac ctt ttc cac     2632
 Thr Pro Ser Ser Gly Arg His Glu His Gly Leu Leu Asn Leu Phe His
                 800                 805                 810

 gcc atg gag ggc atc agc cac ctt cac ctc ctg gtg gtc aaa gag tat     2680
 Ala Met Glu Gly Ile Ser His Leu His Leu Leu Val Val Lys Glu Tyr
             815                 820                 825

 gag atg cct ctg tac cgc aag tac tgg ccc aac cac atc atg ctg gtg     2728
 Glu Met Pro Leu Tyr Arg Lys Tyr Trp Pro Asn His Ile Met Leu Val
         830                 835                 840

 ctt ccc ggc atg ttc aat aat gca ggc gtg ggt gct gcc agg ttc ctc     2776
 Leu Pro Gly Met Phe Asn Asn Ala Gly Val Gly Ala Ala Arg Phe Leu
     845                 850                 855

 atc aag gag cta tca tat cac aac cta gaa ttg gag aga aac cgc ctg     2824
 Ile Lys Glu Leu Ser Tyr His Asn Leu Glu Leu Glu Arg Asn Arg Leu
 860                 865                 870                 875

 gag gag cta ggc att aaa cgc cag tgt gtc tgg cct ttc atc gtc atg     2872
 Glu Glu Leu Gly Ile Lys Arg Gln Cys Val Trp Pro Phe Ile Val Met
                 880                 885                 890

 atg gat gac tca tgt gtc cta tgg aac att cac agt gtt cag gag cca     2920
 Met Asp Asp Ser Cys Val Leu Trp Asn Ile His Ser Val Gln Glu Pro
             895                 900                 905

 tcc agc cag ccc atg gaa gta gga gtt tcc agt aag aat gtg tcc ttg     2968
 Ser Ser Gln Pro Met Glu Val Gly Val Ser Ser Lys Asn Val Ser Leu
         910                 915                 920

 aag act gtc ttg cag cac att gaa gcc aca cca aaa att gtc cac tat     3016
 Lys Thr Val Leu Gln His Ile Glu Ala Thr Pro Lys Ile Val His Tyr
     925                 930                 935

 gca atc ttg ggc ata cag aaa tgg agc agc aag ctg act tct cag agc     3064
 Ala Ile Leu Gly Ile Gln Lys Trp Ser Ser Lys Leu Thr Ser Gln Ser
 940                 945                 950                 955

 cta aag gcc cca ttc tct agg tgt cac gtg cat gat ttc att ctc ctc     3112
 Leu Lys Ala Pro Phe Ser Arg Cys His Val His Asp Phe Ile Leu Leu
                 960                 965                 970

 aac aca gac ttg act cag aat gtg cag tat gac ttc aac agg tat ttc     3160
 Asn Thr Asp Leu Thr Gln Asn Val Gln Tyr Asp Phe Asn Arg Tyr Phe
             975                 980                 985

 tgt gaa gat gct gac ttt aat ctg aga aca aac agt agt ggc ctg ctc     3208
 Cys Glu Asp Ala Asp Phe Asn Leu Arg Thr Asn Ser Ser Gly Leu Leu
         990                 995                1000

 atc tgc cgc ttt aat aac ttc agt ctc atg aag aaa cat gtt cag gtt     3256
 Ile Cys Arg Phe Asn Asn Phe Ser Leu Met Lys Lys His Val Gln Val
    1005                1010                1015

 gga ggg caa agg gac ttt atc att aaa cca aag atc atg gtg tca gag     3304
 Gly Gly Gln Arg Asp Phe Ile Ile Lys Pro Lys Ile Met Val Ser Glu
1020                1025                1030                1035

 agc tta gca ccc atc ttg ccc ctt caa tac atc tgt gct ccc gac agt     3352
 Ser Leu Ala Pro Ile Leu Pro Leu Gln Tyr Ile Cys Ala Pro Asp Ser
                1040                1045                1050

 gaa cac aca cta ctg gca gcc cct gca cag ttt ctc ctg gag aaa ttc     3400
 Glu His Thr Leu Leu Ala Ala Pro Ala Gln Phe Leu Leu Glu Lys Phe
            1055                1060                1065

 ctt cag cac gcc tca tat aaa ctc ttc ccc aaa gcc atc cat aac ttc     3448
 Leu Gln His Ala Ser Tyr Lys Leu Phe Pro Lys Ala Ile His Asn Phe
        1070                1075                1080

 agg agt cct gtg ctg gcc att gac tgc tac ctt aac att gga cca gag     3496
 Arg Ser Pro Val Leu Ala Ile Asp Cys Tyr Leu Asn Ile Gly Pro Glu
    1085                1090                1095

 gtg gcc ata tgc tat atc agc tcc aga ccc cac tcc agc aat gtc aac     3544
 Val Ala Ile Cys Tyr Ile Ser Ser Arg Pro His Ser Ser Asn Val Asn
1100                1105                1110                1115

 tgt gaa ggg gtg ttt ttc agt gga ctc ctt ttg tac ctc tgt gac tct     3592
 Cys Glu Gly Val Phe Phe Ser Gly Leu Leu Leu Tyr Leu Cys Asp Ser
                1120                1125                1130

 ttt gta ggt gct gat ctt aag aaa ttt aaa ttt cta aaa ggt gct aca     3640
 Phe Val Gly Ala Asp Leu Lys Lys Phe Lys Phe Leu Lys Gly Ala Thr
            1135                1140                1145

 ctg tgt gtc atc tgc caa gac aga agt tcc ttg cgc caa aca att gtc     3688
 Leu Cys Val Ile Cys Gln Asp Arg Ser Ser Leu Arg Gln Thr Ile Val
        1150                1155                1160

 cgc tta gag cta gaa gat gag tgg cag ttc cgc ctc cgg gac gag ttt     3736
 Arg Leu Glu Leu Glu Asp Glu Trp Gln Phe Arg Leu Arg Asp Glu Phe
    1165                1170                1175

 caa act gct aac agc agt gat gac aag cct ctc tac ttt ctt act gga     3784
 Gln Thr Ala Asn Ser Ser Asp Asp Lys Pro Leu Tyr Phe Leu Thr Gly
1180                1185                1190                1195

 cgt cat gta tga                                                     3796
 Arg His Val 






      <210> 420
      <211> 1312
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (86)..(1312)

      <400> 420
 gagagcgtgc ggaaaatgaa acataattgt taacttactc cacagagctc atcagaaagt     60

 aaatgaaata aaagataggc ataaa  atg tca tta aat gaa ctt gaa att ctg     112
                              Met Ser Leu Asn Glu Leu Glu Ile Leu
                                1               5

 aga aat agt gcc gtt agt caa gaa aga aag cta caa aat tcc atg ctg      160
 Arg Asn Ser Ala Val Ser Gln Glu Arg Lys Leu Gln Asn Ser Met Leu
  10                  15                  20                  25

 aaa cac gcc aac aat gtt acc atc aga gag agc atg caa aac gat gtg      208
 Lys His Ala Asn Asn Val Thr Ile Arg Glu Ser Met Gln Asn Asp Val
                  30                  35                  40

 cgc aaa att gta tca aaa ctt cag gaa atg aaa gaa aag aag gaa gcc      256
 Arg Lys Ile Val Ser Lys Leu Gln Glu Met Lys Glu Lys Lys Glu Ala
              45                  50                  55

 cag tta aat aac att gac aga ctt gcc aac acg atc aca atg atc gaa      304
 Gln Leu Asn Asn Ile Asp Arg Leu Ala Asn Thr Ile Thr Met Ile Glu
          60                  65                  70

 gag gag atg gtg cag ctt cgc aaa aga tac gaa aaa gct gtt cag cat      352
 Glu Glu Met Val Gln Leu Arg Lys Arg Tyr Glu Lys Ala Val Gln His
      75                  80                  85

 cga aat gaa agt ggc gtt cag ctg ata gag cgg gaa gaa gaa ata tgc      400
 Arg Asn Glu Ser Gly Val Gln Leu Ile Glu Arg Glu Glu Glu Ile Cys
  90                  95                 100                 105

 att ttt tat gaa aaa ata aat atc caa gag aag atg aaa cta aat gga      448
 Ile Phe Tyr Glu Lys Ile Asn Ile Gln Glu Lys Met Lys Leu Asn Gly
                 110                 115                 120

 gaa att gaa ata cat cta ctg gaa gaa aag atc caa ttc ctg aaa atg      496
 Glu Ile Glu Ile His Leu Leu Glu Glu Lys Ile Gln Phe Leu Lys Met
             125                 130                 135

 aag att gct gag aag caa aga caa att tgt gtg acc cag aaa tta ctg      544
 Lys Ile Ala Glu Lys Gln Arg Gln Ile Cys Val Thr Gln Lys Leu Leu
         140                 145                 150

 cca gcc aag agg tcc ctg gat gcc gac cta gct gtg ctc caa att cag      592
 Pro Ala Lys Arg Ser Leu Asp Ala Asp Leu Ala Val Leu Gln Ile Gln
     155                 160                 165

 ttt tca cag tgt aca gac aga att aaa gac ctg gag aaa cag ttc gta      640
 Phe Ser Gln Cys Thr Asp Arg Ile Lys Asp Leu Glu Lys Gln Phe Val
 170                 175                 180                 185

 aag cct gat ggt gag aat aga gct cgc ttc ctt cca ggg aaa gat ctg      688
 Lys Pro Asp Gly Glu Asn Arg Ala Arg Phe Leu Pro Gly Lys Asp Leu
                 190                 195                 200

 acc gaa aaa gaa atg atc caa aaa tta gac aag ctg gaa cta caa ctg      736
 Thr Glu Lys Glu Met Ile Gln Lys Leu Asp Lys Leu Glu Leu Gln Leu
             205                 210                 215

 gcc aag aag gag gag aag ctg ctg gag aag gat ttc atc tat gag cag      784
 Ala Lys Lys Glu Glu Lys Leu Leu Glu Lys Asp Phe Ile Tyr Glu Gln
         220                 225                 230

 gtc tcc agg ctc aca gac agg ctc tgc agc aaa act cag ggc tgc aag      832
 Val Ser Arg Leu Thr Asp Arg Leu Cys Ser Lys Thr Gln Gly Cys Lys
     235                 240                 245

 cag gac aca ctg ctc tta gcc aag aag atg aat ggc tat caa aga agg      880
 Gln Asp Thr Leu Leu Leu Ala Lys Lys Met Asn Gly Tyr Gln Arg Arg
 250                 255                 260                 265

 atc aaa aat gca act gag aaa atg atg gct ctt gtt gct gag ctg tcc      928
 Ile Lys Asn Ala Thr Glu Lys Met Met Ala Leu Val Ala Glu Leu Ser
                 270                 275                 280

 atg aaa caa gcc cta acc att gaa ctc caa aag gaa gtc agg gag aaa      976
 Met Lys Gln Ala Leu Thr Ile Glu Leu Gln Lys Glu Val Arg Glu Lys
             285                 290                 295

 gaa gac ttc atc ttc act tgc aat tcc agg ata gaa aaa ggt ctg cca     1024
 Glu Asp Phe Ile Phe Thr Cys Asn Ser Arg Ile Glu Lys Gly Leu Pro
         300                 305                 310

 ctc aat aag gaa att gag aaa gaa tgg ttg aaa gtc ctt cga gat gaa     1072
 Leu Asn Lys Glu Ile Glu Lys Glu Trp Leu Lys Val Leu Arg Asp Glu
     315                 320                 325

 gaa atg cac gcc ttg gcc atc gct gaa aag tct cag gag ttc ttg gaa     1120
 Glu Met His Ala Leu Ala Ile Ala Glu Lys Ser Gln Glu Phe Leu Glu
 330                 335                 340                 345

 gca gat aat cgc cag ctg ccc aat ggt gtt tac aca act gca gag cag     1168
 Ala Asp Asn Arg Gln Leu Pro Asn Gly Val Tyr Thr Thr Ala Glu Gln
                 350                 355                 360

 cgt ccg aat gcc tac atc cca gaa gca gat gcc act ctt cct ttg cca     1216
 Arg Pro Asn Ala Tyr Ile Pro Glu Ala Asp Ala Thr Leu Pro Leu Pro
             365                 370                 375

 aaa cct tat ggt gct ttg gct cct ttt aaa ccc agt gaa cct gga gcc     1264
 Lys Pro Tyr Gly Ala Leu Ala Pro Phe Lys Pro Ser Glu Pro Gly Ala
         380                 385                 390

 aat atg agg cac ata agg aaa cct gtt ata aag cca gtt gaa atc tga     1312
 Asn Met Arg His Ile Arg Lys Pro Val Ile Lys Pro Val Glu Ile 
     395                 400                 405





      <210> 421
      <211> 932
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(491)

      <400> 421
 ggagcctggc taggccggca gccggatggc cgcagcttcc ggggccggcc   atg ctt      56
                                                          Met Leu
                                                            1

 cgc ggt ccg tgg cgc ttt ttt tgg ctc ttt ctc ctg ctg ctg ctc ccg      104
 Arg Gly Pro Trp Arg Phe Phe Trp Leu Phe Leu Leu Leu Leu Leu Pro
           5                  10                  15

 ggc gcg ccc gac cca cgc gtc cgc tcc agg ccg tgg gag gga acc gac      152
 Gly Ala Pro Asp Pro Arg Val Arg Ser Arg Pro Trp Glu Gly Thr Asp
      20                  25                  30

 gag ccg ggc tcg gcc tgg gcc tgg ccg ggc ttc cag cgc ctg cag gag      200
 Glu Pro Gly Ser Ala Trp Ala Trp Pro Gly Phe Gln Arg Leu Gln Glu
  35                  40                  45                  50

 cag ctc agg gcg gcg ggt gcc ctc tcc aag cgg tac tgg acg ctc ttc      248
 Gln Leu Arg Ala Ala Gly Ala Leu Ser Lys Arg Tyr Trp Thr Leu Phe
                  55                  60                  65

 agc tgc cag gtg tgg ccc gac gac tgt gac gag gac gag gag gca gcc      296
 Ser Cys Gln Val Trp Pro Asp Asp Cys Asp Glu Asp Glu Glu Ala Ala
              70                  75                  80

 acg ggg ccc ctg ggc tgg cgc ctt cct ctg ttg ggc cag cgg tac ctg      344
 Thr Gly Pro Leu Gly Trp Arg Leu Pro Leu Leu Gly Gln Arg Tyr Leu
          85                  90                  95

 gac ctc ctg acc acg tgg tac tgc agc ttc aaa gac tgc tgc cct aga      392
 Asp Leu Leu Thr Thr Trp Tyr Cys Ser Phe Lys Asp Cys Cys Pro Arg
     100                 105                 110

 ggg gat tgc aga atc tcc aac aac ttt aca gga gca gct gat gag cca      440
 Gly Asp Cys Arg Ile Ser Asn Asn Phe Thr Gly Ala Ala Asp Glu Pro
 115                 120                 125                 130

 gat ccg gga gac gca gca gct ctg cca cca gac cct gtt cat ctt cga      488
 Asp Pro Gly Asp Ala Ala Ala Leu Pro Pro Asp Pro Val His Leu Arg
                 135                 140                 145

 tga agcg gagaagctgc acccagggct gctggaggtc cttgggccac acttagaacg      545
 


 ccgggcccct gagggccaca gggctgagtc tccatggact atctttctgt ttctcagtaa    605

 tctcaggggc gatataatca atgaggtggt cctaaagttg ctcaaggctg gatggtcccg    665

 ggaagaaatt acgatggaac acctggagcc ccacctccag gcggagattg tggagaccat    725

 agacaatggc tttgggccac agccgtcttg tgaagggaaa acctgattga ctacttcatc    785

 cccttcctgc cctttcggag taccgtcacg tgagggctgt gtgcacggga tgccttcctg    845

 agcccagaag cttcctgtat aaagaagaga cactggatga aatagcccaa atgatgggta    905

 tgttcccaag aggaacaatc ttattcc                                        932




      <210> 422
      <211> 793
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (165)..(668)

      <400> 422
 agcgggaggt ctacctgttt tggggaggct gctgcgacga agagttccct cagcctccgg     60

 ccttgtgtgt ccgactcggc agcagtgtta agttgctttt acagagttaa caggtctcca    120

 agaaatttta aaaaaggtca ttattgctgt ggtttgagct cagc atg gct gta gtc     176
                                                  Met Ala Val Val
                                                    1

 atc cgt tta ctg ggg ctt cct ttt att gcg ggg cct gtg gat att cgt      224
 Ile Arg Leu Leu Gly Leu Pro Phe Ile Ala Gly Pro Val Asp Ile Arg
   5                  10                  15                  20

 cac ttc ttc acg gga ttg act att cct gat gga gga gtg cat ata att      272
 His Phe Phe Thr Gly Leu Thr Ile Pro Asp Gly Gly Val His Ile Ile
                  25                  30                  35

 gga ggg gaa att ggg gag gct ttt att att ttt gca aca gat gaa gat      320
 Gly Gly Glu Ile Gly Glu Ala Phe Ile Ile Phe Ala Thr Asp Glu Asp
              40                  45                  50

 gca aga cgt gcc ata agt cgt tca gga ggg ttt atc aag gat tca tct      368
 Ala Arg Arg Ala Ile Ser Arg Ser Gly Gly Phe Ile Lys Asp Ser Ser
          55                  60                  65

 gta gag ctc ttt ctt agt agc aag gca gaa atg cag aag act ata gaa      416
 Val Glu Leu Phe Leu Ser Ser Lys Ala Glu Met Gln Lys Thr Ile Glu
      70                  75                  80

 atg aaa aga act gat cgt gta gga aga ggg cgt cca gga tct ggg aca      464
 Met Lys Arg Thr Asp Arg Val Gly Arg Gly Arg Pro Gly Ser Gly Thr
  85                  90                  95                 100

 tca ggg gtt gac agc ctg tct aat ttt att gag tct gtt aag gaa gaa      512
 Ser Gly Val Asp Ser Leu Ser Asn Phe Ile Glu Ser Val Lys Glu Glu
                 105                 110                 115

 gca agt aat tct gga tat ggc tct tca att aat caa gat gct ggg ttt      560
 Ala Ser Asn Ser Gly Tyr Gly Ser Ser Ile Asn Gln Asp Ala Gly Phe
             120                 125                 130

 cat act aat ggt aca gga cat ggt aat tta agg cca aga aag aca agg      608
 His Thr Asn Gly Thr Gly His Gly Asn Leu Arg Pro Arg Lys Thr Arg
         135                 140                 145

 cca ttg aag gcc gag aat cct tac ttg ttt cta cga ggc ttt gcc tta      656
 Pro Leu Lys Ala Glu Asn Pro Tyr Leu Phe Leu Arg Gly Phe Ala Leu
     150                 155                 160

 cct agt aaa tga aga tgatgtacgt gtctttttct ctggtttgtg cgtggatgga      711
 Pro Ser Lys 
 165

 gtaattttct taaaacatca tgatggccga ataatggtga tgccatagta aaattgcttc    771

 atgtgtgatg cttcagggta cc                                             793




      <210> 423
      <211> 2837
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(2507)

      <220>
      <221> misc_feature
      <222> (1)...(2837)
      <223> n = a,t,c or g

      <400> 423
 gccagtatga agtgctgcgg tgccgaccag tg  atg atg tgg ttt gag aag ctg      53
                                      Met Met Trp Phe Glu Lys Leu
                                        1               5

 tat gct ggc ctg cag tgc gta gag aag tac ctc atc tac ccc gcc gtg      101
 Tyr Ala Gly Leu Gln Cys Val Glu Lys Tyr Leu Ile Tyr Pro Ala Val
          10                  15                  20

 gtg ctc aac gcc ctc acg gtg gac gcc cac aca gtc gtc agc cac ccg      149
 Val Leu Asn Ala Leu Thr Val Asp Ala His Thr Val Val Ser His Pro
      25                  30                  35

 gac aag tac tgc ttc tac tgc cgg gcg ctg ctg atg acc gtg gct ggg      197
 Asp Lys Tyr Cys Phe Tyr Cys Arg Ala Leu Leu Met Thr Val Ala Gly
  40                  45                  50                  55

 ctg aag ctg ctg cgc tca gcc ttc tgc tgc ccc cca cag cag tac ctg      245
 Leu Lys Leu Leu Arg Ser Ala Phe Cys Cys Pro Pro Gln Gln Tyr Leu
                  60                  65                  70

 acg ttg gcc ttc acc gtc ctg ctc ttc cac ttt gac tac ccg cgc ctc      293
 Thr Leu Ala Phe Thr Val Leu Leu Phe His Phe Asp Tyr Pro Arg Leu
              75                  80                  85

 tcc cag ggc ttt ctg ctt gac tac ttc ctc atg tcc ctg ctt tgc agc      341
 Ser Gln Gly Phe Leu Leu Asp Tyr Phe Leu Met Ser Leu Leu Cys Ser
          90                  95                 100

 aag ctg tgg gac ttg ctg tac aag ctg cgt ttc gtg ctg acc tac atc      389
 Lys Leu Trp Asp Leu Leu Tyr Lys Leu Arg Phe Val Leu Thr Tyr Ile
     105                 110                 115

 gcg ccc tgg cag atc acc tgg ggc tcg gct ttc cac gct ttt gcc cag      437
 Ala Pro Trp Gln Ile Thr Trp Gly Ser Ala Phe His Ala Phe Ala Gln
 120                 125                 130                 135

 ccg ttt gcc gtg cca cac tcg gcc atg ctg ttc gtc cag gcc ctg ctc      485
 Pro Phe Ala Val Pro His Ser Ala Met Leu Phe Val Gln Ala Leu Leu
                 140                 145                 150

 tcg ggg ctc ttc tcc acg cct ctc aac cca ctg cta ggc agt gcc gtc      533
 Ser Gly Leu Phe Ser Thr Pro Leu Asn Pro Leu Leu Gly Ser Ala Val
             155                 160                 165

 ttc atc atg tcc tac gct cgg ccc ctc aag ttc tgg gag cgc gac tac      581
 Phe Ile Met Ser Tyr Ala Arg Pro Leu Lys Phe Trp Glu Arg Asp Tyr
         170                 175                 180

 aac act aaa cgt gtg gat cat tcc aac acc cgc ctg gtc aca cag ctg      629
 Asn Thr Lys Arg Val Asp His Ser Asn Thr Arg Leu Val Thr Gln Leu
     185                 190                 195

 gac agg aac cct ggc gct gat gac aac aac ctc aac tcc atc ttc tat      677
 Asp Arg Asn Pro Gly Ala Asp Asp Asn Asn Leu Asn Ser Ile Phe Tyr
 200                 205                 210                 215

 gag cac ttg aca cgt tcg ctg cag cac aca ctg tgt ggg gac ctg gtg      725
 Glu His Leu Thr Arg Ser Leu Gln His Thr Leu Cys Gly Asp Leu Val
                 220                 225                 230

 ctg ggc cgc tgg ggc aac tat ggc cct ggt gac tgc ttc gtc ctg gcc      773
 Leu Gly Arg Trp Gly Asn Tyr Gly Pro Gly Asp Cys Phe Val Leu Ala
             235                 240                 245

 tct gac tac ctc aac gcc ctg gtg cac ctc atc gag gtt ggc aat ggc      821
 Ser Asp Tyr Leu Asn Ala Leu Val His Leu Ile Glu Val Gly Asn Gly
         250                 255                 260

 ctc gtc acc ttc cag ctg cgt ggc ctt gag ttc cgg ggc act tac tgc      869
 Leu Val Thr Phe Gln Leu Arg Gly Leu Glu Phe Arg Gly Thr Tyr Cys
     265                 270                 275

 cag cag cgc gag gtg gag gct atc acc gag ggt gtg gag gag gac gag      917
 Gln Gln Arg Glu Val Glu Ala Ile Thr Glu Gly Val Glu Glu Asp Glu
 280                 285                 290                 295

 ggc tgt tgc tgc tgt gaa cct ggc cac ctg cca cgg gtc ctg tcc ttc      965
 Gly Cys Cys Cys Cys Glu Pro Gly His Leu Pro Arg Val Leu Ser Phe
                 300                 305                 310

 aat gct gcc ttt ggg cag cgc tgg ctg gct tgg gag gta aca gcc agc     1013
 Asn Ala Ala Phe Gly Gln Arg Trp Leu Ala Trp Glu Val Thr Ala Ser
             315                 320                 325

 aag tac gtg ctg gag ggc tat agc att agt gac aat aat gct gcc tcc     1061
 Lys Tyr Val Leu Glu Gly Tyr Ser Ile Ser Asp Asn Asn Ala Ala Ser
         330                 335                 340

 atg ctg cag gtt ttc gac ctc cgc aag atc ctc atc acc tac tat gtc     1109
 Met Leu Gln Val Phe Asp Leu Arg Lys Ile Leu Ile Thr Tyr Tyr Val
     345                 350                 355

 aag agc atc atc tac tac gtg agc cgc tca cca aag ctg gag gtg tgg     1157
 Lys Ser Ile Ile Tyr Tyr Val Ser Arg Ser Pro Lys Leu Glu Val Trp
 360                 365                 370                 375

 ctc agc cat gag ggc atc acg gca gcc ctg agg cct gtg cgg gtg ccc     1205
 Leu Ser His Glu Gly Ile Thr Ala Ala Leu Arg Pro Val Arg Val Pro
                 380                 385                 390

 ggc tat gcc gac tcg gat ccc acc ttc tcg ctg agt gtg gat gag gac     1253
 Gly Tyr Ala Asp Ser Asp Pro Thr Phe Ser Leu Ser Val Asp Glu Asp
             395                 400                 405

 tat gac ctc cgc ctg tct ggc ctc tcg ctg ccc tcc ttt tgt gct gtg     1301
 Tyr Asp Leu Arg Leu Ser Gly Leu Ser Leu Pro Ser Phe Cys Ala Val
         410                 415                 420

 cac ctc gag tgg atc cag tac tgc gcc tcc cgg cgc agc cag ccc gtg     1349
 His Leu Glu Trp Ile Gln Tyr Cys Ala Ser Arg Arg Ser Gln Pro Val
     425                 430                 435

 gac cag gat tgg aac tcc ccg ctg gtc acg ctg tgt ttt ggc ctg tgt     1397
 Asp Gln Asp Trp Asn Ser Pro Leu Val Thr Leu Cys Phe Gly Leu Cys
 440                 445                 450                 455

 gtg ctg ggc cgc cgg gcc ctg ggg aca gcc tct cac agc atg tct gca     1445
 Val Leu Gly Arg Arg Ala Leu Gly Thr Ala Ser His Ser Met Ser Ala
                 460                 465                 470

 agc ctg gag ccc ttc ctc tac ggc ctg cac gcc ctg ttc aag ggg gat     1493
 Ser Leu Glu Pro Phe Leu Tyr Gly Leu His Ala Leu Phe Lys Gly Asp
             475                 480                 485

 ttt cgc atc acc tcc cca cgt gac gag tgg gtc ttt gcc gac atg gac     1541
 Phe Arg Ile Thr Ser Pro Arg Asp Glu Trp Val Phe Ala Asp Met Asp
         490                 495                 500

 ctg ctt cac cgc gtt gtg gcg cct ggg gtt cgc atg gcc ctc aag ctt     1589
 Leu Leu His Arg Val Val Ala Pro Gly Val Arg Met Ala Leu Lys Leu
     505                 510                 515

 cac cag gac cac ttc acg tcc cca gat gaa tat gag gag cca gca gcc     1637
 His Gln Asp His Phe Thr Ser Pro Asp Glu Tyr Glu Glu Pro Ala Ala
 520                 525                 530                 535

 cta tac gat gcc att gcg gcc aac gag gag cgg ctg gtc atc tca cat     1685
 Leu Tyr Asp Ala Ile Ala Ala Asn Glu Glu Arg Leu Val Ile Ser His
                 540                 545                 550

 gag ggt gac cca gca tgg cgc agc gcc atc ctc agc aac acg ccc tcc     1733
 Glu Gly Asp Pro Ala Trp Arg Ser Ala Ile Leu Ser Asn Thr Pro Ser
             555                 560                 565

 ctg ctg gcg ctg cgc cat gtc ctg gat gat gcc tcc gac gag tac aag     1781
 Leu Leu Ala Leu Arg His Val Leu Asp Asp Ala Ser Asp Glu Tyr Lys
         570                 575                 580

 atc atc atg ctc aac cgg cgc cac ctc agc ttc cga gtc atc aag gtg     1829
 Ile Ile Met Leu Asn Arg Arg His Leu Ser Phe Arg Val Ile Lys Val
     585                 590                 595

 aac cgg gag tgc gtg cgc ggc ctg tgg gcc ggg cag cag cag gag ctg     1877
 Asn Arg Glu Cys Val Arg Gly Leu Trp Ala Gly Gln Gln Gln Glu Leu
 600                 605                 610                 615

 gtg ttc ctg cgc aac cgc tac ccc atc tac gtg tcg cct ctc acc acc     1925
 Val Phe Leu Arg Asn Arg Tyr Pro Ile Tyr Val Ser Pro Leu Thr Thr
                 620                 625                 630

 tcg ctg gct ggc agc cac ccc cag cta cgg gca ctg tgg ggt ggc ccc     1973
 Ser Leu Ala Gly Ser His Pro Gln Leu Arg Ala Leu Trp Gly Gly Pro
             635                 640                 645

 atc agc ctg ggt gcc att gcc cac tgg ctc ctg cgc acc tgg gag agg     2021
 Ile Ser Leu Gly Ala Ile Ala His Trp Leu Leu Arg Thr Trp Glu Arg
         650                 655                 660

 ctt cac aag ggc tgt ggc gcc ggc tgc aat agt ggc ggg aac gtg gat     2069
 Leu His Lys Gly Cys Gly Ala Gly Cys Asn Ser Gly Gly Asn Val Asp
     665                 670                 675

 gat tca gac tgt agt ggg ggc ggt ggc ctg acc tcc ctc agc aat aac     2117
 Asp Ser Asp Cys Ser Gly Gly Gly Gly Leu Thr Ser Leu Ser Asn Asn
 680                 685                 690                 695

 ccc ccc gtg gca cac ccc aca cct gag aac acg gca ggc aat ggt gac     2165
 Pro Pro Val Ala His Pro Thr Pro Glu Asn Thr Ala Gly Asn Gly Asp
                 700                 705                 710

 caa ccc ctc cca cca ggc cct ggc tgg ggg ccg cgg tcc tcc ctg agt     2213
 Gln Pro Leu Pro Pro Gly Pro Gly Trp Gly Pro Arg Ser Ser Leu Ser
             715                 720                 725

 ggc tct ggt gat ggg cgg ccc cca cct ctg ctg cag tgg cct ccc cct     2261
 Gly Ser Gly Asp Gly Arg Pro Pro Pro Leu Leu Gln Trp Pro Pro Pro
         730                 735                 740

 cgg ctc cct gga cca ccc cct gca tcg cct atc ccc aca gag ggt ccc     2309
 Arg Leu Pro Gly Pro Pro Pro Ala Ser Pro Ile Pro Thr Glu Gly Pro
     745                 750                 755

 cgg acc tca cgg ccc cct ggc ccg ggt ctt ctc agt tct gag ggc ccc     2357
 Arg Thr Ser Arg Pro Pro Gly Pro Gly Leu Leu Ser Ser Glu Gly Pro
 760                 765                 770                 775

 agt gga aag tgg agc ctg ggg ggc cgg aag ggg ctg gga gga tct gac     2405
 Ser Gly Lys Trp Ser Leu Gly Gly Arg Lys Gly Leu Gly Gly Ser Asp
                 780                 785                 790

 ggg gag cca gcc tca ggg agc ccc aaa gga ggt acc ccc aaa tct cag     2453
 Gly Glu Pro Ala Ser Gly Ser Pro Lys Gly Gly Thr Pro Lys Ser Gln
             795                 800                 805

 gcg cct cta gac tca gct cag ctc agc tca gcc tca gcc cga tgt cag     2501
 Ala Pro Leu Asp Ser Ala Gln Leu Ser Ser Ala Ser Ala Arg Cys Gln
         810                 815                 820

 cac tga ggctcaaccc ccagagcttc caggacattc cttgctggac agagtgccct      2557
 His 


 gagagtggcc cagctatggg tgccctgggg aggctggcct atngaggagc gtgagagccg   2617

 gaggcagccc tgggacacag aacgagccac ctgcggcccg gaccactccg aggtagaccg   2677

 accggcgggg cctgggacca gagggggtgg cacaagtgac cgacggggcg gcagcaaggg   2737

 gcacacggtg acgcgcccac gcggcggcaa gggaccacgc cacacgggcc ggcggcaccc   2797

 gcgcggccgg gcggggcagg gcagtgaagg caaacgcgcc                         2837




      <210> 424
      <211> 2030
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(1919)

      <400> 424
 gccagtatga agtgctgcgg tgccgaccag tg  atg atg tgg ttt gag aag ctg      53
                                      Met Met Trp Phe Glu Lys Leu
                                        1               5

 tat gct ggc ctg cag tgc gta gag aag tac ctc atc tac ccc gcc gtg      101
 Tyr Ala Gly Leu Gln Cys Val Glu Lys Tyr Leu Ile Tyr Pro Ala Val
          10                  15                  20

 gtg ctc aac gcc ctc acg gtg gac gcc cac aca gtc gtc agc cac ccg      149
 Val Leu Asn Ala Leu Thr Val Asp Ala His Thr Val Val Ser His Pro
      25                  30                  35

 gac aag tac tgc ttc tac tgc cgg gcg ctg ctg atg acc gtg gct ggg      197
 Asp Lys Tyr Cys Phe Tyr Cys Arg Ala Leu Leu Met Thr Val Ala Gly
  40                  45                  50                  55

 ctg aag ctg ctg cgc tca gcc ttc tgc tgc ccc cca cag cag tac ctg      245
 Leu Lys Leu Leu Arg Ser Ala Phe Cys Cys Pro Pro Gln Gln Tyr Leu
                  60                  65                  70

 acg ttg gcc ttc acc gtc ctg ctc ttc cac ttt gac tac ccg cgc ctc      293
 Thr Leu Ala Phe Thr Val Leu Leu Phe His Phe Asp Tyr Pro Arg Leu
              75                  80                  85

 tcc cag ggc ttt ctg ctt gac tac ttc ctc atg tcc ctg ctt tgc agc      341
 Ser Gln Gly Phe Leu Leu Asp Tyr Phe Leu Met Ser Leu Leu Cys Ser
          90                  95                 100

 aag ctg tgg gac ttg ctg tac aag ctg cgt ttc gtg ctg acc tac atc      389
 Lys Leu Trp Asp Leu Leu Tyr Lys Leu Arg Phe Val Leu Thr Tyr Ile
     105                 110                 115

 gcg ccc tgg cag atc acc tgg ggc tcg gct ttc cac gct ttt gcc cag      437
 Ala Pro Trp Gln Ile Thr Trp Gly Ser Ala Phe His Ala Phe Ala Gln
 120                 125                 130                 135

 ccg ttt gcc gtg cca cac tcg gcc atg ctg ttc gtc cag gcc ctg ctc      485
 Pro Phe Ala Val Pro His Ser Ala Met Leu Phe Val Gln Ala Leu Leu
                 140                 145                 150

 tcg ggg ctc ttc tcc acg cct ctc aac cca ctg cta ggc agt gcc gtc      533
 Ser Gly Leu Phe Ser Thr Pro Leu Asn Pro Leu Leu Gly Ser Ala Val
             155                 160                 165

 ttc atc atg tcc tac gct cgg ccc ctc aag ttc tgg gag cgc gac tac      581
 Phe Ile Met Ser Tyr Ala Arg Pro Leu Lys Phe Trp Glu Arg Asp Tyr
         170                 175                 180

 aac act aaa cgt gtg gat cat tcc aac acc cgc ctg gtc aca cag ctg      629
 Asn Thr Lys Arg Val Asp His Ser Asn Thr Arg Leu Val Thr Gln Leu
     185                 190                 195

 gac agg aac cct ggc gct gat gac aac aac ctc aac tcc atc ttc tat      677
 Asp Arg Asn Pro Gly Ala Asp Asp Asn Asn Leu Asn Ser Ile Phe Tyr
 200                 205                 210                 215

 gag cac ttg aca cgt tcg ctg cag cac aca ctg tgt ggg gac ctg gtg      725
 Glu His Leu Thr Arg Ser Leu Gln His Thr Leu Cys Gly Asp Leu Val
                 220                 225                 230

 ctg ggc cgc tgg ggc aac tat ggc cct ggt gac tgc ttc gtc ctg gcc      773
 Leu Gly Arg Trp Gly Asn Tyr Gly Pro Gly Asp Cys Phe Val Leu Ala
             235                 240                 245

 tct gac tac ctc aac gcc ctg gtg cac ctc atc gag gtt ggc aat ggc      821
 Ser Asp Tyr Leu Asn Ala Leu Val His Leu Ile Glu Val Gly Asn Gly
         250                 255                 260

 ctc gtc acc ttc cag ctg cgt ggc ctt gag ttc cgg ggc act tac tgc      869
 Leu Val Thr Phe Gln Leu Arg Gly Leu Glu Phe Arg Gly Thr Tyr Cys
     265                 270                 275

 cag cag cgc gag gtg gag gct atc acc gag ggt gtg gag gag gac gag      917
 Gln Gln Arg Glu Val Glu Ala Ile Thr Glu Gly Val Glu Glu Asp Glu
 280                 285                 290                 295

 ggc tgt tgc tgc tgt gaa cct ggc cac ctg cca cgg gtc ctg tcc ttc      965
 Gly Cys Cys Cys Cys Glu Pro Gly His Leu Pro Arg Val Leu Ser Phe
                 300                 305                 310

 aat gct gcc ttt ggg cag cgc tgg ctg gct tgg gag gta aca gcc agc     1013
 Asn Ala Ala Phe Gly Gln Arg Trp Leu Ala Trp Glu Val Thr Ala Ser
             315                 320                 325

 aag tac gtg ctg gag ggc tat agc att agt gac aat aat gct gcc tcc     1061
 Lys Tyr Val Leu Glu Gly Tyr Ser Ile Ser Asp Asn Asn Ala Ala Ser
         330                 335                 340

 atg ctg cag gtt ttc gac ctc cgc aag atc ctc atc acc tac tat gtc     1109
 Met Leu Gln Val Phe Asp Leu Arg Lys Ile Leu Ile Thr Tyr Tyr Val
     345                 350                 355

 aag agc atc atc tac tac gtg agc cgc tca cca aag ctg gag gtg tgg     1157
 Lys Ser Ile Ile Tyr Tyr Val Ser Arg Ser Pro Lys Leu Glu Val Trp
 360                 365                 370                 375

 ctc agc cat gag ggc atc acg gca gcc ctg agg cct gtg cgg gtg ccc     1205
 Leu Ser His Glu Gly Ile Thr Ala Ala Leu Arg Pro Val Arg Val Pro
                 380                 385                 390

 ggc tat gcc gac tcg gat ccc acc ttc tcg ctg agt gtg gat gag gac     1253
 Gly Tyr Ala Asp Ser Asp Pro Thr Phe Ser Leu Ser Val Asp Glu Asp
             395                 400                 405

 tat gac ctc cgc ctg tct ggc ctc tcg ctg ccc tcc ttt tgt gct gtg     1301
 Tyr Asp Leu Arg Leu Ser Gly Leu Ser Leu Pro Ser Phe Cys Ala Val
         410                 415                 420

 cac ctc gag tgg atc cag tac tgc gcc tcc cgg cgc agc cag ccc gtg     1349
 His Leu Glu Trp Ile Gln Tyr Cys Ala Ser Arg Arg Ser Gln Pro Val
     425                 430                 435

 gac cag gat tgg aac tcc ccg ctg gtc acg ctg tgt ttt ggc ctg tgt     1397
 Asp Gln Asp Trp Asn Ser Pro Leu Val Thr Leu Cys Phe Gly Leu Cys
 440                 445                 450                 455

 gtg ctg ggc cgc cgg gcc ctg ggg aca gcc tct cac agc atg tct gca     1445
 Val Leu Gly Arg Arg Ala Leu Gly Thr Ala Ser His Ser Met Ser Ala
                 460                 465                 470

 agc ctg gag ccc ttc ctc tac ggc ctg cac gcc ctg ttc aag ggg gat     1493
 Ser Leu Glu Pro Phe Leu Tyr Gly Leu His Ala Leu Phe Lys Gly Asp
             475                 480                 485

 ttt cgc atc acc tcc cca cgt gac gag tgg gtc ttt gcc gac atg gac     1541
 Phe Arg Ile Thr Ser Pro Arg Asp Glu Trp Val Phe Ala Asp Met Asp
         490                 495                 500

 ctg ctt cac cgc gtt gtg gcg cct ggg gtt cgc atg gcc ctc aag ctt     1589
 Leu Leu His Arg Val Val Ala Pro Gly Val Arg Met Ala Leu Lys Leu
     505                 510                 515

 cac cag gac cac ttc acg tcc cca gat gaa tat gag gag cca gca gcc     1637
 His Gln Asp His Phe Thr Ser Pro Asp Glu Tyr Glu Glu Pro Ala Ala
 520                 525                 530                 535

 cta tac gat gcc att gcg gcc aac gag gag cgg ctg gtc atc tca cat     1685
 Leu Tyr Asp Ala Ile Ala Ala Asn Glu Glu Arg Leu Val Ile Ser His
                 540                 545                 550

 gag ggt gac cca gca tgg cgc agc gcc atc ctc agc aac acg ccc tcc     1733
 Glu Gly Asp Pro Ala Trp Arg Ser Ala Ile Leu Ser Asn Thr Pro Ser
             555                 560                 565

 ctg ctg gcg ctg cgc cat gtc ctg gat gat gcc tcc gac gag tac aag     1781
 Leu Leu Ala Leu Arg His Val Leu Asp Asp Ala Ser Asp Glu Tyr Lys
         570                 575                 580

 atc atc atg ctc aac cgg cgc cac ctc agc ttc cga gtc atc aag gtt     1829
 Ile Ile Met Leu Asn Arg Arg His Leu Ser Phe Arg Val Ile Lys Val
     585                 590                 595

 ggg ccg gcc cca cct gcc cta agc cct cgt ggc cag ccc ggc tgg ttt     1877
 Gly Pro Ala Pro Pro Ala Leu Ser Pro Arg Gly Gln Pro Gly Trp Phe
 600                 605                 610                 615

 tgt aag ata ctg ggt tgg tgc aca gtg att ttt ttc ttg taa tttaaac     1926
 Cys Lys Ile Leu Gly Trp Cys Thr Val Ile Phe Phe Leu 
                 620                 625

 aggcccagca ttgctggttc tatttaatgg acatgagata atgttagagg ttttaaagtg   1986

 attaaacgtg cagactatgc aaaccaggaa aaaaaaaaaa aaaa                    2030




      <210> 425
      <211> 1018
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2)..(337)

      <400> 425
 t    atg tgg gac ccc ccc ctt gtc gtg ccg cgg ttt cct cgg ccc gct      46
      Met Trp Asp Pro Pro Leu Val Val Pro Arg Phe Pro Arg Pro Ala
        1               5                  10                  15

 ttg gcc cag ttc cag acc cgt tgg gcc cgg cgc ccc ccc gca ggg gtg       94
 Leu Ala Gln Phe Gln Thr Arg Trp Ala Arg Arg Pro Pro Ala Gly Val
                  20                  25                  30

 ttc gaa cct ttt tcg ggg gcc ggg ccc ccc aac aaa gtc ttt ttt ctg      142
 Phe Glu Pro Phe Ser Gly Ala Gly Pro Pro Asn Lys Val Phe Phe Leu
              35                  40                  45

 cgt ctt tgt gta tgt ttt ttt ttt gcg aca gag tct tgc act gtc acc      190
 Arg Leu Cys Val Cys Phe Phe Phe Ala Thr Glu Ser Cys Thr Val Thr
          50                  55                  60

 tgg gct gga gtg cag tgg tgc aat ctc agc tca ctg caa cct ctg cct      238
 Trp Ala Gly Val Gln Trp Cys Asn Leu Ser Ser Leu Gln Pro Leu Pro
      65                  70                  75

 tcc ggg ttc aag cca ttc tcc tgc ctc agc ctc cca ggt agc tgg gat      286
 Ser Gly Phe Lys Pro Phe Ser Cys Leu Ser Leu Pro Gly Ser Trp Asp
  80                  85                  90                  95

 tac agg cac ctg cca cca tgc cca gct aac ttt ttg tat tgt ttt ttt      334
 Tyr Arg His Leu Pro Pro Cys Pro Ala Asn Phe Leu Tyr Cys Phe Phe
                 100                 105                 110

 tag taga gatggggttt cactatgttg gccaggctgg tctcaaactc ctgacctcgt      391
 


 gatctgtgcg cctcggcccc ccaaagtgct gggagtacag gcgtgaacca ccgcgtccgg    451

 ctggggctgc ttatttaaat cccctagaaa gagggattct ccagctacac cacaccctca    511

 cttggaagga ccctcctccc agagagggag ctgtggaaaa agcctgacct gccccacagg    571

 gcagtaggtc gagcctggct ggtgagcaag gaggtacggg gatccctgag gcctcccacc    631

 cagggcccag ggagcctgcc tgctgtgagc acttcctcca gtcctgatgg actcggctct    691

 gcccggagcc cccggtctct gcacacacag ctgactggag aaagccactt ccatctcatg    751

 gacagggaca gaacaaggct gagggaggtg agcaatgcag ccaggcccgg gggctacaat    811

 ggctgctggc aaaacccacc atctcagcaa tagttcagcg cgaagggctg agaactgtga    871

 gaagcgaatc gcgacgttta ttttgctctt ccttagcctc ttgtggcaga tttggggcaa    931

 aacaacagat taaatcttgt gtacatatat ttacatgtgg atagacacac tgcagaagag    991

 gtctctgttt tgtaaactct aacgaca                                       1018




      <210> 426
      <211> 764
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (194)..(721)

      <400> 426
 gctgctggcg cgggctccgg ctccggaggt ctgtgcggcc ctcaatgtca ctgtgtcccc     60

 ggggcccgtg gttgactacc tggaggggga gaatgccact ctcctctgcc acgtctccca    120

 gaaaaggcgg aaggacagct tgctggccgt gcgctggttc tttgcacact cctccgactc    180

 ccaggaggcc ttg   atg gtg aag atg acc aag ctc cgg gtg gtg cag tac     229
                  Met Val Lys Met Thr Lys Leu Arg Val Val Gln Tyr
                    1               5                  10

 tat ggg aat ttc agc cgc agc gcc aaa cgg cgg agg ctg cgc ctg ctg      277
 Tyr Gly Asn Phe Ser Arg Ser Ala Lys Arg Arg Arg Leu Arg Leu Leu
          15                  20                  25

 gag gag cag cgg ggg gcg ctc tac agg ctc tcc gtc ttg aca ctg cag      325
 Glu Glu Gln Arg Gly Ala Leu Tyr Arg Leu Ser Val Leu Thr Leu Gln
      30                  35                  40

 ccc tcc gat caa ggg cat tac gtc tgc aga gtc cag gaa atc agc agg      373
 Pro Ser Asp Gln Gly His Tyr Val Cys Arg Val Gln Glu Ile Ser Arg
  45                  50                  55                  60

 cac agg aac aag tgg acg gcc tgg tcc aat ggc tcc tca gcc acg gaa      421
 His Arg Asn Lys Trp Thr Ala Trp Ser Asn Gly Ser Ser Ala Thr Glu
                  65                  70                  75

 atg aga gtc att tcc ctc aaa gct tct gaa gag tca tcc ttt gag aaa      469
 Met Arg Val Ile Ser Leu Lys Ala Ser Glu Glu Ser Ser Phe Glu Lys
              80                  85                  90

 aca aaa gag act tgg gca ttt ttt gaa gat ctc tat gtg tat gct gtc      517
 Thr Lys Glu Thr Trp Ala Phe Phe Glu Asp Leu Tyr Val Tyr Ala Val
          95                 100                 105

 ctc gtg tgc tgc gtg ggg atc ctc agc att ctg ctc ttc atg ctg gtc      565
 Leu Val Cys Cys Val Gly Ile Leu Ser Ile Leu Leu Phe Met Leu Val
     110                 115                 120

 atc gtc tgg cag tct gtg ttt aac aag cgg aaa tcc aga gtg aga cat      613
 Ile Val Trp Gln Ser Val Phe Asn Lys Arg Lys Ser Arg Val Arg His
 125                 130                 135                 140

 tat ttg gtg aaa tgc cct cag aac agc tca ggg gag act gtc act agc      661
 Tyr Leu Val Lys Cys Pro Gln Asn Ser Ser Gly Glu Thr Val Thr Ser
                 145                 150                 155

 gtg acc agg ctt ggc ccc act aca gcc caa gaa ggg caa gag gca gaa      709
 Val Thr Arg Leu Gly Pro Thr Thr Ala Gln Glu Gly Gln Glu Ala Glu
             160                 165                 170

 gga gaa gcc tga cat tcctcccgca gtccctgcca aagctccgat agcccccacc      764
 Gly Glu Ala 
         175





      <210> 427
      <211> 2014
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (664)..(1560)

      <400> 427
 tagtccagtg cggtggaatt cgctgatcct gcactacgac gagacctacc gcgaggtgaa     60

 gtatggcatc atggggctgc ccgacatcga cagcaaaatg ctgatgggca tcaacgtgac    120

 tcccatcgcc gccctgctct acacacctgt gctcatcagg ttttttggaa cgaagtggat    180

 gatgttcctc gctgtgggca tctacgccct ctttgtctcc accaactact gggagcgcta    240

 ctacacgctt gtgccctcgg ctgtggccct gggcatggcc atcgtgcctc tttgggcttc    300

 catgggcaac tacatcacca ggatggcgca gaagtaccat gagtactccc actacaagga    360

 gcaggatggg caggggatga agcagcggcc tccgcggggc tcccacgcgc cctatctcct    420

 ggtcttccaa gccatcttct acagcttctt ccatctgagc ttcgcctgcg cccagctgcc    480

 catgatttat ttcctgaacc actacctgta tgacctgaac cacacgctgt acaatgtgca    540

 gagctgcggc accaacagcc acgggatcct cagcggcttc aacaagacgg ttctgcggac    600

 gctcccgcgg agcggaaacc tcattgtggt ggagagcgtg ctcatggcag tggcttcctg    660

 gcc  atg ctg ctg gtg ctg ggt ttg tgc gga gcc gct tac cgg ccc acg     708
      Met Leu Leu Val Leu Gly Leu Cys Gly Ala Ala Tyr Arg Pro Thr
        1               5                  10                  15

 gag gag atc gat ctg cgc agc gtg ggc tgg ggc aac atc ttc cag ctg      756
 Glu Glu Ile Asp Leu Arg Ser Val Gly Trp Gly Asn Ile Phe Gln Leu
                  20                  25                  30

 ccc ttc aag cac gtg cgt gac tac cgc ctg cgc cac ctc gtg cct ttc      804
 Pro Phe Lys His Val Arg Asp Tyr Arg Leu Arg His Leu Val Pro Phe
              35                  40                  45

 ttt atc tac agc ggc ttc gag gtg ctc ttt gcc tgc act ggt atc gcc      852
 Phe Ile Tyr Ser Gly Phe Glu Val Leu Phe Ala Cys Thr Gly Ile Ala
          50                  55                  60

 ttg ggc tat ggc gtg tgc tcg gtg ggg ctg gag cgg ctg gct tac ctc      900
 Leu Gly Tyr Gly Val Cys Ser Val Gly Leu Glu Arg Leu Ala Tyr Leu
      65                  70                  75

 ctc gtg gct tac agc ctg ggc gcc tca gcc gcc tca ctc ctg ggc ctg      948
 Leu Val Ala Tyr Ser Leu Gly Ala Ser Ala Ala Ser Leu Leu Gly Leu
  80                  85                  90                  95

 ctg ggc ctg tgg ctg cca cgc ccg gtg ccc ctg gtg gcc gga gca ggg      996
 Leu Gly Leu Trp Leu Pro Arg Pro Val Pro Leu Val Ala Gly Ala Gly
                 100                 105                 110

 gtg cac ctg ctg ctc acc ttc atc ctc ttt ttc tgg gcc cct gtg cct     1044
 Val His Leu Leu Leu Thr Phe Ile Leu Phe Phe Trp Ala Pro Val Pro
             115                 120                 125

 cgg gtc ctg caa cac agc tgg atc ctc tat gtg gca gct gcc ctt tgg     1092
 Arg Val Leu Gln His Ser Trp Ile Leu Tyr Val Ala Ala Ala Leu Trp
         130                 135                 140

 ggt gtg ggc agt gcc ctg aac aag act gga ctc agc aca ctc ctg gga     1140
 Gly Val Gly Ser Ala Leu Asn Lys Thr Gly Leu Ser Thr Leu Leu Gly
     145                 150                 155

 atc ttg tac gaa gac aag gag aga cag gac ttc atc ttc acc atc tac     1188
 Ile Leu Tyr Glu Asp Lys Glu Arg Gln Asp Phe Ile Phe Thr Ile Tyr
 160                 165                 170                 175

 cac tgg tgg cag gct gtg gcc atc ttc acc gtg tac ctg ggc tcg agc     1236
 His Trp Trp Gln Ala Val Ala Ile Phe Thr Val Tyr Leu Gly Ser Ser
                 180                 185                 190

 ctg cac atg aag gct aag ctg gcg gtg ctg ctg gtg acg ctg gtg gcg     1284
 Leu His Met Lys Ala Lys Leu Ala Val Leu Leu Val Thr Leu Val Ala
             195                 200                 205

 gcc gcg gtc tcc tac ctg cgg atg gag cag aag ctg cgg cgg ggc gtg     1332
 Ala Ala Val Ser Tyr Leu Arg Met Glu Gln Lys Leu Arg Arg Gly Val
         210                 215                 220

 gcc ccg cgc cag ccc cgc atc ccg cgg ccc cag cac aag gtg cgc ggt     1380
 Ala Pro Arg Gln Pro Arg Ile Pro Arg Pro Gln His Lys Val Arg Gly
     225                 230                 235

 tac cgc tac ttg gag gag gac aac tcg gac gag agc gac gcg gag ggc     1428
 Tyr Arg Tyr Leu Glu Glu Asp Asn Ser Asp Glu Ser Asp Ala Glu Gly
 240                 245                 250                 255

 gag cat ggg gac ggc gcg gag gag gag gcg ccg ccc gca ggg ccc agg     1476
 Glu His Gly Asp Gly Ala Glu Glu Glu Ala Pro Pro Ala Gly Pro Arg
                 260                 265                 270

 cct ggc ccc gag ccc gct gga ctc ggc cgc cgg ccc tgc ccg tac gaa     1524
 Pro Gly Pro Glu Pro Ala Gly Leu Gly Arg Arg Pro Cys Pro Tyr Glu
             275                 280                 285

 cag gcg cag ggg gga gac ggg ccg gag gag cag tga gggg ccgcctggtc     1574
 Gln Ala Gln Gly Gly Asp Gly Pro Glu Glu Gln 
         290                 295

 cccggactca gcctccctcc tcgccggcct cagtttacca cgtctgaggt cggggggacc   1634

 ccctccgagt cccgcgctgt cttcaaaggc ccctgtctcc cctccccgac gttggggacg   1694

 cccctcccag agcccaggtc acctccgggc ttccgcagcc ccctccaagg cggagtggag   1754

 ccttgggaac ccctcggcca agcacagggg ttcgaaaata cagctgaaac cccgcgggcc   1814

 cttagcacgc gccccagcgc cggagcacgg tcagggtctt cttgcgaccc ggcccgctcc   1874

 agatccccac agctctcggc cgcggacccg ggccgcgtgt gagcgcactt tgcacctcct   1934

 atccccaggg tccgccgaga gccacgattt tttacagaaa atgagcaata aagagatttt   1994

 gtactgtcaa aaaaaaaaaa                                               2014




      <210> 428
      <211> 1699
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (20)..(1399)

      <400> 428
 gctgcgggcc ggtgaagat atg gcg gcg tct gcg tct gca gct gca ggg gag      52
                      Met Ala Ala Ser Ala Ser Ala Ala Ala Gly Glu
                        1               5                  10

 gag gac tgg gtc ctt ccc tct gaa gtt gaa gta ttg gag tcc atc tat      100
 Glu Asp Trp Val Leu Pro Ser Glu Val Glu Val Leu Glu Ser Ile Tyr
              15                  20                  25

 cta gat gaa cta cag gtg att aaa gga aat ggc aga act tca cca tgg      148
 Leu Asp Glu Leu Gln Val Ile Lys Gly Asn Gly Arg Thr Ser Pro Trp
          30                  35                  40

 gag atc tac atc act ttg cat cct gcc act gca gag gac cag gat tca      196
 Glu Ile Tyr Ile Thr Leu His Pro Ala Thr Ala Glu Asp Gln Asp Ser
      45                  50                  55

 cag tat gtc tgc ttc act ctg gtg ctt cag gtc cca gca gag tat ccc      244
 Gln Tyr Val Cys Phe Thr Leu Val Leu Gln Val Pro Ala Glu Tyr Pro
  60                  65                  70                  75

 cat gag gtg cca cag atc tct atc cga aat ccc cga gga ctt tca gat      292
 His Glu Val Pro Gln Ile Ser Ile Arg Asn Pro Arg Gly Leu Ser Asp
                  80                  85                  90

 gaa cag atc cac acg atc tta cag gtg ctg ggc cac gtg gcc aag gct      340
 Glu Gln Ile His Thr Ile Leu Gln Val Leu Gly His Val Ala Lys Ala
              95                 100                 105

 ggg ctg ggc act gcc atg ctg tat gaa ctc att gag aaa ggg aag gaa      388
 Gly Leu Gly Thr Ala Met Leu Tyr Glu Leu Ile Glu Lys Gly Lys Glu
         110                 115                 120

 att ctc aca gat aac aac atc cct cat ggc cag tgt gtc atc tgc ctc      436
 Ile Leu Thr Asp Asn Asn Ile Pro His Gly Gln Cys Val Ile Cys Leu
     125                 130                 135

 tat ggt ttc cag gag aag gag gcc ttt acc aaa aca ccc tgt tac cac      484
 Tyr Gly Phe Gln Glu Lys Glu Ala Phe Thr Lys Thr Pro Cys Tyr His
 140                 145                 150                 155

 tac ttc cac tgc cac tgc ctt gct cgg tac atc cag cac atg gag caa      532
 Tyr Phe His Cys His Cys Leu Ala Arg Tyr Ile Gln His Met Glu Gln
                 160                 165                 170

 gag ctg aag gca caa gga cag gag cag gaa cag gaa cgg cag cat gct      580
 Glu Leu Lys Ala Gln Gly Gln Glu Gln Glu Gln Glu Arg Gln His Ala
             175                 180                 185

 aca acc aaa cag aag gca gtc ggt gtg cag tgt cca gtg tgc aga gag      628
 Thr Thr Lys Gln Lys Ala Val Gly Val Gln Cys Pro Val Cys Arg Glu
         190                 195                 200

 ccc ctc gtg tat gat ctt gcc tca ctg aaa gca gcc cct gaa ccc caa      676
 Pro Leu Val Tyr Asp Leu Ala Ser Leu Lys Ala Ala Pro Glu Pro Gln
     205                 210                 215

 cag ccc atg gag ctg tac cag ccc agt gca gag agc ttg cgc cag caa      724
 Gln Pro Met Glu Leu Tyr Gln Pro Ser Ala Glu Ser Leu Arg Gln Gln
 220                 225                 230                 235

 gaa gaa cgc aag cgg ctc tac cag agg cag cag gag cgg ggg gga atc      772
 Glu Glu Arg Lys Arg Leu Tyr Gln Arg Gln Gln Glu Arg Gly Gly Ile
                 240                 245                 250

 att gac ctt gag gct gag cga aac cga tac ttc atc agc ctt cag cag      820
 Ile Asp Leu Glu Ala Glu Arg Asn Arg Tyr Phe Ile Ser Leu Gln Gln
             255                 260                 265

 cct cct gcc cct gcg gaa cct gag tca gct gta gat gtc tcc aaa gga      868
 Pro Pro Ala Pro Ala Glu Pro Glu Ser Ala Val Asp Val Ser Lys Gly
         270                 275                 280

 tcc caa cca ccc agc acc ctt gca gca gaa cta tcc acc tca cca gcc      916
 Ser Gln Pro Pro Ser Thr Leu Ala Ala Glu Leu Ser Thr Ser Pro Ala
     285                 290                 295

 gtc caa tcc act ttg cca cct cct ctg cct gtg gcg acc cag cac ata      964
 Val Gln Ser Thr Leu Pro Pro Pro Leu Pro Val Ala Thr Gln His Ile
 300                 305                 310                 315

 tgt gag aag att cca ggg acc agg tca aat cag caa agg ttg ggc gaa     1012
 Cys Glu Lys Ile Pro Gly Thr Arg Ser Asn Gln Gln Arg Leu Gly Glu
                 320                 325                 330

 acc cag aaa gct atg cta gat ccc ccc aag ccc agt cga ggt ccc tgg     1060
 Thr Gln Lys Ala Met Leu Asp Pro Pro Lys Pro Ser Arg Gly Pro Trp
             335                 340                 345

 cga cag ccc gaa cgg agg cac cca aag gga ggg gag tgc cac gcc cct     1108
 Arg Gln Pro Glu Arg Arg His Pro Lys Gly Gly Glu Cys His Ala Pro
         350                 355                 360

 aaa ggt acc cgt gac acc cag gaa ctg cca cct cct gag ggg ccc ctc     1156
 Lys Gly Thr Arg Asp Thr Gln Glu Leu Pro Pro Pro Glu Gly Pro Leu
     365                 370                 375

 aag gag ccc atg gac cta aag cca gaa ccc cat agc caa gga gtt gaa     1204
 Lys Glu Pro Met Asp Leu Lys Pro Glu Pro His Ser Gln Gly Val Glu
 380                 385                 390                 395

 ggt cct cca caa gag aag ggg cct ggc agc tgg cag ggg ccc cca ccc     1252
 Gly Pro Pro Gln Glu Lys Gly Pro Gly Ser Trp Gln Gly Pro Pro Pro
                 400                 405                 410

 cgc agg act cgg gac tgt gtt cgc tgg gag cgc tct aaa ggc cgg aca     1300
 Arg Arg Thr Arg Asp Cys Val Arg Trp Glu Arg Ser Lys Gly Arg Thr
             415                 420                 425

 ccc ggt tct tcc tac cct cgc ctg cct cgg ggc cag gga gca tac cgg     1348
 Pro Gly Ser Ser Tyr Pro Arg Leu Pro Arg Gly Gln Gly Ala Tyr Arg
         430                 435                 440

 cct ggt act cgg agg gag tcc ctg ggc ctg gaa tct aag gat ggt tcc     1396
 Pro Gly Thr Arg Arg Glu Ser Leu Gly Leu Glu Ser Lys Asp Gly Ser
     445                 450                 455

 tag cagg acttggtggg gggaacaggg aattggggat gggagggagg caataaagat     1453
 


 atttggcctt ctttggcttt ctttgcttag cagcgcctag cctgtgagga atggctcttt   1513

 ttctcaattc ctaataagat tggggtgtgg cagagcaccc cccaactttg ctctgaagtc   1573

 tgctctccga agagctgggt aaagagggtc tgacatctca tcagctagta tagtgagttt   1633

 cacggaacac tattgggatg tctgcatgta agcagagtcc ttaggaccca ccgttaacaa   1693

 ctcatt                                                              1699




      <210> 429
      <211> 2035
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1650)

      <400> 429
  atg gat gac aaa gat att gac aaa gaa cta agg cag aaa tta aac ttt      48
  Met Asp Asp Lys Asp Ile Asp Lys Glu Leu Arg Gln Lys Leu Asn Phe
    1               5                  10                  15

 tcc tat tgt gag gag act gag att gaa ggg cag aag aaa gta gaa gaa       96
 Ser Tyr Cys Glu Glu Thr Glu Ile Glu Gly Gln Lys Lys Val Glu Glu
              20                  25                  30

 agc agg gag gct tcg agc caa acc cca gag aag ggt gaa gtg cag gat      144
 Ser Arg Glu Ala Ser Ser Gln Thr Pro Glu Lys Gly Glu Val Gln Asp
          35                  40                  45

 tca gag gca aag ggt aca cca cct tgg act ccc ctt agc aac gtg cat      192
 Ser Glu Ala Lys Gly Thr Pro Pro Trp Thr Pro Leu Ser Asn Val His
      50                  55                  60

 gag ctc gac aca tct tcg gaa aaa gac aaa gaa agt cca gat cag att      240
 Glu Leu Asp Thr Ser Ser Glu Lys Asp Lys Glu Ser Pro Asp Gln Ile
  65                  70                  75                  80

 ttg agg act cca gtg tca cac cct ctc aaa tgt cct gag aca cca gcc      288
 Leu Arg Thr Pro Val Ser His Pro Leu Lys Cys Pro Glu Thr Pro Ala
                  85                  90                  95

 caa cca gac agc agg agc aag ctg ctg ccc agt gac agc ccc tct act      336
 Gln Pro Asp Ser Arg Ser Lys Leu Leu Pro Ser Asp Ser Pro Ser Thr
             100                 105                 110

 ccc aaa acc atg ctg agc cgg ttg gtg att tct cca aca ggg aag ctt      384
 Pro Lys Thr Met Leu Ser Arg Leu Val Ile Ser Pro Thr Gly Lys Leu
         115                 120                 125

 cct tcc aga ggc cct aag cat ttg aag ctc aca cct gct ccc ctc aag      432
 Pro Ser Arg Gly Pro Lys His Leu Lys Leu Thr Pro Ala Pro Leu Lys
     130                 135                 140

 gat gag atg acc tca ttg gct ctg gtc aat att aat ccc ttc act cca      480
 Asp Glu Met Thr Ser Leu Ala Leu Val Asn Ile Asn Pro Phe Thr Pro
 145                 150                 155                 160

 gag tcc tat aaa aaa tta ttt ctt caa tct ggt ggc aag agg aaa ata      528
 Glu Ser Tyr Lys Lys Leu Phe Leu Gln Ser Gly Gly Lys Arg Lys Ile
                 165                 170                 175

 aga aga tgt gtt tta cga gaa acc aac atg gct tcc cgc tat gaa aaa      576
 Arg Arg Cys Val Leu Arg Glu Thr Asn Met Ala Ser Arg Tyr Glu Lys
             180                 185                 190

 gaa ttc ttg gag gtt gaa aaa att ggg gtt ggc gaa ttt ggt aca gtc      624
 Glu Phe Leu Glu Val Glu Lys Ile Gly Val Gly Glu Phe Gly Thr Val
         195                 200                 205

 tac aag tgc att aag agg ctg gat gga tgt gtt tat gca ata aag cgc      672
 Tyr Lys Cys Ile Lys Arg Leu Asp Gly Cys Val Tyr Ala Ile Lys Arg
     210                 215                 220

 tct atg aaa act ttt aca gaa tta tca aat gag aat tcg gct ttg cat      720
 Ser Met Lys Thr Phe Thr Glu Leu Ser Asn Glu Asn Ser Ala Leu His
 225                 230                 235                 240

 gaa gtt tat gct cac gca gtg ctt ggg cat cac ccc cat gtg gta cgt      768
 Glu Val Tyr Ala His Ala Val Leu Gly His His Pro His Val Val Arg
                 245                 250                 255

 tac tat tcc tca tgg gca gaa gat gac cac atg atc att cag aat gaa      816
 Tyr Tyr Ser Ser Trp Ala Glu Asp Asp His Met Ile Ile Gln Asn Glu
             260                 265                 270

 tac tgc aat ggt ggg agt ttg caa gct gct ata tct gaa aac act aag      864
 Tyr Cys Asn Gly Gly Ser Leu Gln Ala Ala Ile Ser Glu Asn Thr Lys
         275                 280                 285

 tct ggc aat cat ttt gaa gag cca aaa ctc aag gac atc ctt cta cag      912
 Ser Gly Asn His Phe Glu Glu Pro Lys Leu Lys Asp Ile Leu Leu Gln
     290                 295                 300

 att tcc ctt ggc ctt aat tac atc cac aac tct agc atg gta cac ctg      960
 Ile Ser Leu Gly Leu Asn Tyr Ile His Asn Ser Ser Met Val His Leu
 305                 310                 315                 320

 gac atc aaa cct agt aat ata ttc att tgt cac aag atg caa agt gaa     1008
 Asp Ile Lys Pro Ser Asn Ile Phe Ile Cys His Lys Met Gln Ser Glu
                 325                 330                 335

 tcc tct gga gtc ata gaa gaa gtt gaa aat gaa gct gat tgg ttt ctc     1056
 Ser Ser Gly Val Ile Glu Glu Val Glu Asn Glu Ala Asp Trp Phe Leu
             340                 345                 350

 tct gcc aat gtg atg tat aaa att ggt gac ctg ggc cac gca aca tca     1104
 Ser Ala Asn Val Met Tyr Lys Ile Gly Asp Leu Gly His Ala Thr Ser
         355                 360                 365

 ata aac aaa ccc aaa gtg gaa gaa gga gat agt cgc ttc ctg gct aat     1152
 Ile Asn Lys Pro Lys Val Glu Glu Gly Asp Ser Arg Phe Leu Ala Asn
     370                 375                 380

 gag att ttg caa gag gat tac cgg cac ctt ccc aaa gca gac ata ttt     1200
 Glu Ile Leu Gln Glu Asp Tyr Arg His Leu Pro Lys Ala Asp Ile Phe
 385                 390                 395                 400

 gcc ttg gga tta aca att gca gtg gct gca gga gca gag tca ttg ccc     1248
 Ala Leu Gly Leu Thr Ile Ala Val Ala Ala Gly Ala Glu Ser Leu Pro
                 405                 410                 415

 acc aat ggt gct gca tgg cac cat atc cgc aag ggt aac ttt ccg gac     1296
 Thr Asn Gly Ala Ala Trp His His Ile Arg Lys Gly Asn Phe Pro Asp
             420                 425                 430

 gtt cct cag gag ctc tca gaa agc ttt tcc agt ctg ctc aag aac atg     1344
 Val Pro Gln Glu Leu Ser Glu Ser Phe Ser Ser Leu Leu Lys Asn Met
         435                 440                 445

 atc caa cct gat gcc gaa cag aga cct tct gca gca gct ctg gcc aga     1392
 Ile Gln Pro Asp Ala Glu Gln Arg Pro Ser Ala Ala Ala Leu Ala Arg
     450                 455                 460

 aat aca gtt ctc cgg cct tcc ctg gga aaa aca gaa gag ctc caa cag     1440
 Asn Thr Val Leu Arg Pro Ser Leu Gly Lys Thr Glu Glu Leu Gln Gln
 465                 470                 475                 480

 cag ctg aat ttg gaa aag ttc aag act gcc aca ctg gaa agg gaa ctg     1488
 Gln Leu Asn Leu Glu Lys Phe Lys Thr Ala Thr Leu Glu Arg Glu Leu
                 485                 490                 495

 aga gaa gcc cag cag gcc cag tca ccc cag gga tat acc cat cat ggt     1536
 Arg Glu Ala Gln Gln Ala Gln Ser Pro Gln Gly Tyr Thr His His Gly
             500                 505                 510

 gac act ggg gtc tct ggg acc cac aca gga tca aga agc aca aaa cgc     1584
 Asp Thr Gly Val Ser Gly Thr His Thr Gly Ser Arg Ser Thr Lys Arg
         515                 520                 525

 ctg gtg gga gga aag agt gca agg tct tca agc ttt acc tca gga gag     1632
 Leu Val Gly Gly Lys Ser Ala Arg Ser Ser Ser Phe Thr Ser Gly Glu
     530                 535                 540

 cgt gag cct ctg cat taa aggaag aaaaggaaaa cagcccttgg ttggcctatg     1686
 Arg Glu Pro Leu His 
 545

 gattacgagg ttgctgttgc tgattcccca ccaaagatcc caggactcgt tgtacataga   1746

 acggatagaa tttagtttag agttgaagtc acagcttaca gaaatgtgcc tggattcaca   1806

 gcgcttcccc aggtttttga tgctgttcct aagagagaat tccagttctt ggaggaagtg   1866

 ggtctcctag gtgtaccctt tcttgtttgt gtttttcctc ctcgggttcc ccttttgttc   1926

 cggggtgccg ctggcgccgc cttggcctcc tgccgggtgc ttcggccaca tcgcgggggg   1986

 cccggacccc gcccgggccc atgccccccg tggggggtcg gcccccttg               2035




      <210> 430
      <211> 1398
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (291)..(701)

      <400> 430
 gcaccaggtt gcggggtcat tgaaaacaaa gttgtcagtt tagattaaca ggcactcacc     60

 atggtccctc cccctccctc agcatgaaac cagcaggaga aaatcctcaa ctcttggctt    120

 ctccttgggg agacaaaaga gttggaatgt gtgtccagtg tttcaccttt tcagtgggct    180

 gagggactgg cttctgtctt gcttgtcttg gaaagctgac aggggctggt gtattccagg    240

 tgcccaggag ccactgagaa cagaagactt gttgctgctc tagaggacct   atg gta     296
                                                          Met Val
                                                            1

 ggg cag aca gag gat gat aca gct cag cag ctt gtc cct acg tgt ggc      344
 Gly Gln Thr Glu Asp Asp Thr Ala Gln Gln Leu Val Pro Thr Cys Gly
           5                  10                  15

 atg aaa ggt gtt gga gag aga ata gtg gag tat gtg tcc aac att cca      392
 Met Lys Gly Val Gly Glu Arg Ile Val Glu Tyr Val Ser Asn Ile Pro
      20                  25                  30

 gca ctt cag aga gct acc ccc aag gga ctg gct tct gtt tca cct gac      440
 Ala Leu Gln Arg Ala Thr Pro Lys Gly Leu Ala Ser Val Ser Pro Asp
  35                  40                  45                  50

 ttg gag cac agg cag gag tgg aca tac tct aaa agc cca ctg atg gga      488
 Leu Glu His Arg Gln Glu Trp Thr Tyr Ser Lys Ser Pro Leu Met Gly
                  55                  60                  65

 aag ggc acc agg ttg gag gcc tct gaa aac aag aga gct ggg tgg ctt      536
 Lys Gly Thr Arg Leu Glu Ala Ser Glu Asn Lys Arg Ala Gly Trp Leu
              70                  75                  80

 gca gca gct cca gag aac ctg aag tac cac aga cag ata gca cag gga      584
 Ala Ala Ala Pro Glu Asn Leu Lys Tyr His Arg Gln Ile Ala Gln Gly
          85                  90                  95

 gca aaa gat tat gag atc ctg aaa aag gaa acg aac aag ttc atc ttg      632
 Ala Lys Asp Tyr Glu Ile Leu Lys Lys Glu Thr Asn Lys Phe Ile Leu
     100                 105                 110

 aga att tat aca cac tgg tcg aga aga agc atc ctc agg aaa ggt tca      680
 Arg Ile Tyr Thr His Trp Ser Arg Arg Ser Ile Leu Arg Lys Gly Ser
 115                 120                 125                 130

 aaa ggc atg cag aat ctc tag tc aggccgatca gtgaggatct ttctctgtac      733
 Lys Gly Met Gln Asn Leu 
                 135

 agagccagac cacaaagact gggaggggtg atattttttc aaatgcttgg atcccaacat    793

 gatgttaaaa gacacacaaa gaaataggga aacatggcac aatcaaagag tcaaaatatc    853

 caggaaccta ctttaaggaa acacagatat cttcattatc tcagaaggaa ttcagactaa    913

 ccaccataaa catgttcagt gacccaagga aaatgctgca tgaacaaaat ggtatcaaca    973

 tagagattga aaacgtaaaa aggaaccaaa caaacattgt aacagatgca atatgcttct   1033

 ttgaccaaat tgaaagattt actagaggag tttagcagca gtgtttttca aggagaagaa   1093

 ttagtgaact tgaagccagg tcatttgaaa ttatccagtc agagaagcaa aaagaaaaaa   1153

 aaaaaaaaaa gaatgaagac agcctagagt actaatggga cagcatcaat tttatcaatg   1213

 tagattgtat ggaagttcca tatgttggaa agagaaagga gcaaaaagct tatttgaaga   1273

 aatactggcc aaaacttccc aaactgaagg aaggcagtgg acatccagat tcaagaagcc   1333

 agatggactc cagagtagaa caatccgaag acatctacat ggaaacacac tgtaatcaaa   1393

 ttgtc                                                               1398




      <210> 431
      <211> 936
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (311)..(754)

      <400> 431
 gcgaaaggag gctgtgtcct cagcctcctc cctcggcacg cgcctcccat cctgacgggg     60

 actgagagcc caggagagct cggggcgtgt ccaaactgcc gcgccgccct gctccgggtt    120

 tgtcttcctc cctccgtttc tccttccgct gtatctagca tttcggttcc tggaaaggtt    180

 accggagctg cgattggggc tgggaccaaa gttgagtcct ggaaagggag cctggagagc    240

 ggcggtgctg ggaggcccgg ccagctcgat cgcaggcttc cacctggcgg ccaatgcttg    300

 tttgctactg   atg ggt gtg agc aag tta gat att cta tac cgg aga ctt     349
              Met Gly Val Ser Lys Leu Asp Ile Leu Tyr Arg Arg Leu
                1               5                  10

 ctc cta aca aaa ctt ttt atc aga gga tgg gga agg cca gaa gat ctc      397
 Leu Leu Thr Lys Leu Phe Ile Arg Gly Trp Gly Arg Pro Glu Asp Leu
      15                  20                  25

 aaa aga ctc ttt gaa ttc aga aag atg att gga aat cgg gaa aga tgc      445
 Lys Arg Leu Phe Glu Phe Arg Lys Met Ile Gly Asn Arg Glu Arg Cys
  30                  35                  40                  45

 cag aat ctg gtt tca agc gat tat cca gta cac att gat aag att gaa      493
 Gln Asn Leu Val Ser Ser Asp Tyr Pro Val His Ile Asp Lys Ile Glu
                  50                  55                  60

 gag caa tca gat tgt aag atc tta gat gga cac ttt gtt tcc ccc atg      541
 Glu Gln Ser Asp Cys Lys Ile Leu Asp Gly His Phe Val Ser Pro Met
              65                  70                  75

 gct cac tat gtg cct gat atc atg cca att gaa tct gtt att gca agg      589
 Ala His Tyr Val Pro Asp Ile Met Pro Ile Glu Ser Val Ile Ala Arg
          80                  85                  90

 ttc caa ttt att gtg cct aaa gaa tgg aac agc aaa tat aga cct gta      637
 Phe Gln Phe Ile Val Pro Lys Glu Trp Asn Ser Lys Tyr Arg Pro Val
      95                 100                 105

 tgc att cat ctt gct gga aca gga gat cat cat tac tgg agg cga cga      685
 Cys Ile His Leu Ala Gly Thr Gly Asp His His Tyr Trp Arg Arg Arg
 110                 115                 120                 125

 aca cta atg gcc cgt cct atg att aaa gaa gcc cga atg gct tct tta      733
 Thr Leu Met Ala Arg Pro Met Ile Lys Glu Ala Arg Met Ala Ser Leu
                 130                 135                 140

 ttg tta gaa aac cct tat tga tg acgtcagact attcacagaa gaagaaatga      786
 Leu Leu Glu Asn Pro Tyr 
             145

 aactggtgca cagatataaa gaaatgttca acgttgctgg taataaatgt agagttaaaa    846

 caacaatgat caaatattta aaaaaaaaca gtactggtga ggctgctttg aaatgggcac    906

 tcttgttact aatgactgaa aattagttca                                     936




      <210> 432
      <211> 722
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (209)..(343)

      <400> 432
 ccgctccgga attcccgggt cgacccacgc gtccgcggac gcgtgggtcg acccacgcgt     60

 acgcggactc ttgggcggac gcgtgggcgg acacgagggt gcttaggctg gagggcattg    120

 gcacaacctc agctcactgc aacctccacc tcctgggctc aggcaatgcc cctgtctcaa    180

 cctcccgagt agctgggatt gcgggcat   atg cca aca cat ttg gct aat ttt     232
                                  Met Pro Thr His Leu Ala Asn Phe
                                    1               5

 tgt att ttc agt aga gtt gag gtt tca cca tgt tgg aca ggt tgg tct      280
 Cys Ile Phe Ser Arg Val Glu Val Ser Pro Cys Trp Thr Gly Trp Ser
      10                  15                  20

 cga att cct ggt caa gtg agc cgc ctg cct tgg cct ccc aaa gtt ttg      328
 Arg Ile Pro Gly Gln Val Ser Arg Leu Pro Trp Pro Pro Lys Val Leu
  25                  30                  35                  40

 gga ttt cac gcg tga accaccgtgc ccaaccccaa gcggtagttt tttccccacg      383
 Gly Phe His Ala 


 tgtacacact gataccctat ttaacttctt ttctaaattt ggcttagttg ttatggtaaa    443

 atctttcttt tttgtttgcc attttgcaca caaagaacct caaacaaccc taatcataaa    503

 tgagaaaatt taatatacac tcatactagt ttacttgtac gaaggatgaa atagtcatac    563

 atttaatgta aatgagacaa aatatagtaa cagcttgtgt caagggtctc caagatcacc    623

 ctgattcagt gatttgctag aaggactcac agaactcaga agatagttat acacactgtg    683

 atttattatg gtgaaacttt attaagcaaa aaaaaaaaa                           722




      <210> 433
      <211> 1669
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1536)

      <400> 433
  atg atc cct aag ctg ctt tcc ctc ctc tgt ttc agg tca ctg ccc aag      48
  Met Ile Pro Lys Leu Leu Ser Leu Leu Cys Phe Arg Ser Leu Pro Lys
    1               5                  10                  15

 ccg tcc ctc agt gcc tgg ccc agc tcg gtg gtc cct gcc aac agc aat       96
 Pro Ser Leu Ser Ala Trp Pro Ser Ser Val Val Pro Ala Asn Ser Asn
              20                  25                  30

 gtg acg ctg cga tgt tgg act cct gcc aga ggt gtg agc ttt gtt ctc      144
 Val Thr Leu Arg Cys Trp Thr Pro Ala Arg Gly Val Ser Phe Val Leu
          35                  40                  45

 agg aag gga gga att att ctg gag tcc ccg aag ccc ctt gat tct aca      192
 Arg Lys Gly Gly Ile Ile Leu Glu Ser Pro Lys Pro Leu Asp Ser Thr
      50                  55                  60

 gag ggc gcg gcc gaa ttt cac ctc aat aat cta aaa gtc aga aat gct      240
 Glu Gly Ala Ala Glu Phe His Leu Asn Asn Leu Lys Val Arg Asn Ala
  65                  70                  75                  80

 gga gag tac acc tgt gaa tac tac aga aaa gca tcc ccc cac atc ctt      288
 Gly Glu Tyr Thr Cys Glu Tyr Tyr Arg Lys Ala Ser Pro His Ile Leu
                  85                  90                  95

 tca cag cgc agt gac gtc ctt cta ctg ttg gtg aca gga cat tta tct      336
 Ser Gln Arg Ser Asp Val Leu Leu Leu Leu Val Thr Gly His Leu Ser
             100                 105                 110

 aaa cct ttc ctc cga acc tac caa agg ggt aca gtg acc gca ggt gga      384
 Lys Pro Phe Leu Arg Thr Tyr Gln Arg Gly Thr Val Thr Ala Gly Gly
         115                 120                 125

 agg gtg act ctg cag tgc cag aag cga gac caa ttg ttt gtg cct atc      432
 Arg Val Thr Leu Gln Cys Gln Lys Arg Asp Gln Leu Phe Val Pro Ile
     130                 135                 140

 atg ttc gct cta ctg aag gca ggg acg cca tca ccc atc cag ctg cag      480
 Met Phe Ala Leu Leu Lys Ala Gly Thr Pro Ser Pro Ile Gln Leu Gln
 145                 150                 155                 160

 agt cca gcg ggg aag gag ata gac ttc tct ctg gtg gac gtg aca gcc      528
 Ser Pro Ala Gly Lys Glu Ile Asp Phe Ser Leu Val Asp Val Thr Ala
                 165                 170                 175

 ggc gat gct ggg aac tac agc tgc atg tac tac cag aca aag tct ccc      576
 Gly Asp Ala Gly Asn Tyr Ser Cys Met Tyr Tyr Gln Thr Lys Ser Pro
             180                 185                 190

 ttc tgg gcc tca gaa ccc agt gat cag ctt gag ata ttg gtg aca gtt      624
 Phe Trp Ala Ser Glu Pro Ser Asp Gln Leu Glu Ile Leu Val Thr Val
         195                 200                 205

 ccc cca ggt acc aca tcg agc aac tac tcc ctg ggt aac ttc gta cga      672
 Pro Pro Gly Thr Thr Ser Ser Asn Tyr Ser Leu Gly Asn Phe Val Arg
     210                 215                 220

 ctg ggt ctg gct gcc gta att gtg gtt atc atg gga gct ttc ctg gtg      720
 Leu Gly Leu Ala Ala Val Ile Val Val Ile Met Gly Ala Phe Leu Val
 225                 230                 235                 240

 gag gcc tgg tac agc cgg aat gtg tct cca ggg ctg tgt ctg ggc tac      768
 Glu Ala Trp Tyr Ser Arg Asn Val Ser Pro Gly Leu Cys Leu Gly Tyr
                 245                 250                 255

 gaa gat gag aaa aag aat gag aaa ccg ccc aag ccc tcc ctc cac gcc      816
 Glu Asp Glu Lys Lys Asn Glu Lys Pro Pro Lys Pro Ser Leu His Ala
             260                 265                 270

 tgg ccc agc tcg gtg gtt gaa gcc gag agc aat gtg acc ctg aag tgt      864
 Trp Pro Ser Ser Val Val Glu Ala Glu Ser Asn Val Thr Leu Lys Cys
         275                 280                 285

 cag gct cat tcc cag aat gtg aca ttt gtg ctg cgc aag gtg aac gac      912
 Gln Ala His Ser Gln Asn Val Thr Phe Val Leu Arg Lys Val Asn Asp
     290                 295                 300

 tct ggg tac aag cag gaa cag agc tcg gca gaa aac gaa gct gaa ttc      960
 Ser Gly Tyr Lys Gln Glu Gln Ser Ser Ala Glu Asn Glu Ala Glu Phe
 305                 310                 315                 320

 ccc ttc acg gac ctg aag cct aag gat gct ggg agg tac ttt tgt gcc     1008
 Pro Phe Thr Asp Leu Lys Pro Lys Asp Ala Gly Arg Tyr Phe Cys Ala
                 325                 330                 335

 tac aag aca aca gcc tcc cat gag tgg tca gaa agc agt gaa cac ttg     1056
 Tyr Lys Thr Thr Ala Ser His Glu Trp Ser Glu Ser Ser Glu His Leu
             340                 345                 350

 cag ctg gtg gtc aca gga tca ctc cca gaa cct ttg ctc tca gtc aat     1104
 Gln Leu Val Val Thr Gly Ser Leu Pro Glu Pro Leu Leu Ser Val Asn
         355                 360                 365

 gta gac cct ggg atg act cca ggt ctc agg aca ctt cga tgt ctc act     1152
 Val Asp Pro Gly Met Thr Pro Gly Leu Arg Thr Leu Arg Cys Leu Thr
     370                 375                 380

 cca tac aat gga acc gaa tgt att gta att gct ctg ttg aaa atg ggg     1200
 Pro Tyr Asn Gly Thr Glu Cys Ile Val Ile Ala Leu Leu Lys Met Gly
 385                 390                 395                 400

 atc cca gaa cca tta caa gtc agg caa gta aga aaa aac cag act gat     1248
 Ile Pro Glu Pro Leu Gln Val Arg Gln Val Arg Lys Asn Gln Thr Asp
                 405                 410                 415

 ttc atg ctc tgg aac gtg aca agt aat gac agt gga aac tac agc tgt     1296
 Phe Met Leu Trp Asn Val Thr Ser Asn Asp Ser Gly Asn Tyr Ser Cys
             420                 425                 430

 gtg tat tac ctg agc aac tca tca cac ttg gcc tcc ttc ccc agc aac     1344
 Val Tyr Tyr Leu Ser Asn Ser Ser His Leu Ala Ser Phe Pro Ser Asn
         435                 440                 445

 aag ctg gag atc tgg gtg aca gat aaa cac gat gaa ctt gaa gct ccc     1392
 Lys Leu Glu Ile Trp Val Thr Asp Lys His Asp Glu Leu Glu Ala Pro
     450                 455                 460

 tca atg aaa aca gac acc aga acc atc ttt gtc gcc atc ttc agc tgc     1440
 Ser Met Lys Thr Asp Thr Arg Thr Ile Phe Val Ala Ile Phe Ser Cys
 465                 470                 475                 480

 atc tcc atc ctt ctc ctc ttc ctc tca gtc ttc atc atc tac aga tgc     1488
 Ile Ser Ile Leu Leu Leu Phe Leu Ser Val Phe Ile Ile Tyr Arg Cys
                 485                 490                 495

 agc cag cac agt gag ctc aga gaa cgc aaa ggg aga gag ggg gag tga     1536
 Ser Gln His Ser Glu Leu Arg Glu Arg Lys Gly Arg Glu Gly Glu 
             500                 505                 510

 aggattttct cgaaccagcc attccaaact tccggagcag gaggctgccg aggcagattt   1596

 atccaatatg gaaagggtat ctctctcgac ggcagacccc caaggagtga cctatgctga   1656

 gctaagcacc agc                                                      1669




      <210> 434
      <211> 1127
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (176)..(994)

      <400> 434
 gggtcgaccc acgcgtccgg tggggcagag aaccagagtg tcagagcaaa acctcctcta     60

 tctgcacatc ctggggacga accgggcagc cggagagctg cggccggccc agtcccgctc    120

 cgcctttgaa gggtaaaacc caaggcgggg ccttggttct ggcagaaggg acgct atg     178
                                                              Met
                                                                1

 acc gca gaa ttc ctc tcc ctg ctt tgc ctc ggg ctg tgt ctg ggc tac      226
 Thr Ala Glu Phe Leu Ser Leu Leu Cys Leu Gly Leu Cys Leu Gly Tyr
               5                  10                  15

 gaa gat gag aaa aag aat gag aaa ccg ccc aag ccc tcc ctc cac gcc      274
 Glu Asp Glu Lys Lys Asn Glu Lys Pro Pro Lys Pro Ser Leu His Ala
          20                  25                  30

 tgg ccc agc tcg gtg gtt gaa gcc gag agc aat gtg acc ctg aag tgt      322
 Trp Pro Ser Ser Val Val Glu Ala Glu Ser Asn Val Thr Leu Lys Cys
      35                  40                  45

 cag gct cat tcc cag aat gtg aca ttt gtg ctg cgc aag gtg aac gac      370
 Gln Ala His Ser Gln Asn Val Thr Phe Val Leu Arg Lys Val Asn Asp
  50                  55                  60                  65

 tct ggg tac aag cag gaa cag agc tcg gca gaa aac gaa gct gaa ttc      418
 Ser Gly Tyr Lys Gln Glu Gln Ser Ser Ala Glu Asn Glu Ala Glu Phe
                  70                  75                  80

 ccc ttc acg gac ctg aag cct aag gat gct ggg agg tac ttt tgt gcc      466
 Pro Phe Thr Asp Leu Lys Pro Lys Asp Ala Gly Arg Tyr Phe Cys Ala
              85                  90                  95

 tac aag aca aca gcc tcc cat gag tgg tca gaa agc agt gaa cac ttg      514
 Tyr Lys Thr Thr Ala Ser His Glu Trp Ser Glu Ser Ser Glu His Leu
         100                 105                 110

 cag ctg gtg gtc aca gga tca ctc cca gaa cct ttg ctc tca gtc aat      562
 Gln Leu Val Val Thr Gly Ser Leu Pro Glu Pro Leu Leu Ser Val Asn
     115                 120                 125

 gta gac cct ggg atg act cca ggt ctc agg aca ctt cga tgt ctc act      610
 Val Asp Pro Gly Met Thr Pro Gly Leu Arg Thr Leu Arg Cys Leu Thr
 130                 135                 140                 145

 cca tac aat gga acc gaa tgt att gta att gct ctg ttg aaa atg ggg      658
 Pro Tyr Asn Gly Thr Glu Cys Ile Val Ile Ala Leu Leu Lys Met Gly
                 150                 155                 160

 atc cca gaa cca tta caa gtc agg caa gta aga aaa aac cag act gat      706
 Ile Pro Glu Pro Leu Gln Val Arg Gln Val Arg Lys Asn Gln Thr Asp
             165                 170                 175

 ttc atg ctc tgg aac gtg aca agt aat gac agt gga aac tac agc tgt      754
 Phe Met Leu Trp Asn Val Thr Ser Asn Asp Ser Gly Asn Tyr Ser Cys
         180                 185                 190

 gtg tat tac ctg agc aac tca tca cac ttg gcc tcc ttc ccc agc aac      802
 Val Tyr Tyr Leu Ser Asn Ser Ser His Leu Ala Ser Phe Pro Ser Asn
     195                 200                 205

 aag ctg gag atc tgg gtg aca gat aaa cac gat gaa ctt gaa gct ccc      850
 Lys Leu Glu Ile Trp Val Thr Asp Lys His Asp Glu Leu Glu Ala Pro
 210                 215                 220                 225

 tca atg aaa aca gac acc aga acc atc ttt gtc gcc atc ttc agc tgc      898
 Ser Met Lys Thr Asp Thr Arg Thr Ile Phe Val Ala Ile Phe Ser Cys
                 230                 235                 240

 atc tcc atc ctt ctc ctc ttc ctc tca gtc ttc atc atc tac aga tgc      946
 Ile Ser Ile Leu Leu Leu Phe Leu Ser Val Phe Ile Ile Tyr Arg Cys
             245                 250                 255

 agc cag cac agt gag ctc aga gaa cgc aaa ggg aga gag ggg gag tga      994
 Ser Gln His Ser Glu Leu Arg Glu Arg Lys Gly Arg Glu Gly Glu 
         260                 265                 270

 aggattttct cgaaccagcc attccaaact tccggagcag gaggctgccg aggcagattt   1054

 atccaatatg gaaagggtat ctctctcgac ggcagacccc ccaggagtga cctatgctga   1114

 gctaagcacc agc                                                      1127




      <210> 435
      <211> 3122
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (195)..(3122)

      <400> 435
 cggtccggaa ttcccgggtc gacccacgcg tccggcgacg ccaaacatgg cgtgttccta     60

 gaagccgctt tcggcatcag taggcggcgg cgtggggtct ggcagcgtgg ggagagggac    120

 caaccgacgc cacttcgtgt tgggaagtgg gagcgggagg gccgggcaat tcccgaccga    180

 accaaacggt ttcc  atg gat ctc aat agt gcc agc act gtt gtt ctt cag     230
                  Met Asp Leu Asn Ser Ala Ser Thr Val Val Leu Gln
                    1               5                  10

 gtg tta aca cag gcc acc agt cag gat act gct gtg tta aaa cca gct      278
 Val Leu Thr Gln Ala Thr Ser Gln Asp Thr Ala Val Leu Lys Pro Ala
          15                  20                  25

 gag gag cag ttg aag cag tgg gag aca cag cca ggt ttc tat tca gtg      326
 Glu Glu Gln Leu Lys Gln Trp Glu Thr Gln Pro Gly Phe Tyr Ser Val
      30                  35                  40

 ttg ctg aat att ttc acc aac cac act ttg gat ata aat gta agg tgg      374
 Leu Leu Asn Ile Phe Thr Asn His Thr Leu Asp Ile Asn Val Arg Trp
  45                  50                  55                  60

 ctt gct gta ctg tat ttt aaa cat gga att gat cgc tac tgg aga cgt      422
 Leu Ala Val Leu Tyr Phe Lys His Gly Ile Asp Arg Tyr Trp Arg Arg
                  65                  70                  75

 gta gca cct cat gct ctc tca gag gag gag aaa act act ctg cgt gca      470
 Val Ala Pro His Ala Leu Ser Glu Glu Glu Lys Thr Thr Leu Arg Ala
              80                  85                  90

 ggg ctc atc acc aac ttc aat gaa cca ata aac cag att gca act cag      518
 Gly Leu Ile Thr Asn Phe Asn Glu Pro Ile Asn Gln Ile Ala Thr Gln
          95                 100                 105

 att gca gtg ctc att gca aaa gtt gct aga ttg gat tgt ccc aga cag      566
 Ile Ala Val Leu Ile Ala Lys Val Ala Arg Leu Asp Cys Pro Arg Gln
     110                 115                 120

 tgg cct gaa cta att ccc act ctt ata gag tct gtt aaa gtc cag gat      614
 Trp Pro Glu Leu Ile Pro Thr Leu Ile Glu Ser Val Lys Val Gln Asp
 125                 130                 135                 140

 gat ctt cga cag cac aga gca tta ctt acc ttc tat cat gtt acc aag      662
 Asp Leu Arg Gln His Arg Ala Leu Leu Thr Phe Tyr His Val Thr Lys
                 145                 150                 155

 aca ctg gca tct aaa cga ctt gct gct gat aga aaa cta ttt tat gat      710
 Thr Leu Ala Ser Lys Arg Leu Ala Ala Asp Arg Lys Leu Phe Tyr Asp
             160                 165                 170

 tta gct tct gga att tat aat ttt gcc tgc tct ctg tgg aat cac cac      758
 Leu Ala Ser Gly Ile Tyr Asn Phe Ala Cys Ser Leu Trp Asn His His
         175                 180                 185

 aca gac aca ttc ctg caa gaa gtt tct tct ggc aat gaa gct gca att      806
 Thr Asp Thr Phe Leu Gln Glu Val Ser Ser Gly Asn Glu Ala Ala Ile
     190                 195                 200

 ttg agt tca cta gaa cga aca ctg cta tca ttg aaa gtg ctg cgt aag      854
 Leu Ser Ser Leu Glu Arg Thr Leu Leu Ser Leu Lys Val Leu Arg Lys
 205                 210                 215                 220

 tta act gtt aat gga ttt gtg gaa cct cat aag aat atg gag gtg atg      902
 Leu Thr Val Asn Gly Phe Val Glu Pro His Lys Asn Met Glu Val Met
                 225                 230                 235

 ggt ttt tta cat gga ata ttt gaa cgt cta aaa cag ttt ctg gaa tgc      950
 Gly Phe Leu His Gly Ile Phe Glu Arg Leu Lys Gln Phe Leu Glu Cys
             240                 245                 250

 agt aga agt ata ggt aca gat aat gtt tgt aga gat aga ctg gaa aag      998
 Ser Arg Ser Ile Gly Thr Asp Asn Val Cys Arg Asp Arg Leu Glu Lys
         255                 260                 265

 acc atc att ctt ttt act aaa gtg ctt ttg gac ttc ttg gat cag cat     1046
 Thr Ile Ile Leu Phe Thr Lys Val Leu Leu Asp Phe Leu Asp Gln His
     270                 275                 280

 cct ttt tca ttt act cct cta att cag aga tca ctg gaa ttt tct gta     1094
 Pro Phe Ser Phe Thr Pro Leu Ile Gln Arg Ser Leu Glu Phe Ser Val
 285                 290                 295                 300

 agc tat gtt ttt aca gaa gtt ggt gaa ggc gtt aca ttt gaa cga ttc     1142
 Ser Tyr Val Phe Thr Glu Val Gly Glu Gly Val Thr Phe Glu Arg Phe
                 305                 310                 315

 att gtc caa tgt atg aat ctt att aag atg att gtc aaa aat tat gct     1190
 Ile Val Gln Cys Met Asn Leu Ile Lys Met Ile Val Lys Asn Tyr Ala
             320                 325                 330

 tat aag cca tcc aaa aat ttt gaa gat agc agc cct gaa act ctt gaa     1238
 Tyr Lys Pro Ser Lys Asn Phe Glu Asp Ser Ser Pro Glu Thr Leu Glu
         335                 340                 345

 gcc cat aag att aag atg gca ttc ttc aca tat cct act ttg aca gag     1286
 Ala His Lys Ile Lys Met Ala Phe Phe Thr Tyr Pro Thr Leu Thr Glu
     350                 355                 360

 ata tgt aga aga tta gtc tct cat tat ttc cta tta act gaa gaa gaa     1334
 Ile Cys Arg Arg Leu Val Ser His Tyr Phe Leu Leu Thr Glu Glu Glu
 365                 370                 375                 380

 ctg aca atg tgg gaa gaa gac cca gaa ggc ttt aca gtg gaa gaa aca     1382
 Leu Thr Met Trp Glu Glu Asp Pro Glu Gly Phe Thr Val Glu Glu Thr
                 385                 390                 395

 gga gga gat tct tgg aaa tat agt ttg agg cca tgc act gaa gta tta     1430
 Gly Gly Asp Ser Trp Lys Tyr Ser Leu Arg Pro Cys Thr Glu Val Leu
             400                 405                 410

 ttt ata gat ata ttc cat gaa tac aat cag act ctt act cct gta ctt     1478
 Phe Ile Asp Ile Phe His Glu Tyr Asn Gln Thr Leu Thr Pro Val Leu
         415                 420                 425

 cta gaa atg atg caa aca ctt caa gga ccc aca aat gtg gaa gat atg     1526
 Leu Glu Met Met Gln Thr Leu Gln Gly Pro Thr Asn Val Glu Asp Met
     430                 435                 440

 aat gca ctg tta atc aaa gat gct gtg tat aat gct gtt gga tta gct     1574
 Asn Ala Leu Leu Ile Lys Asp Ala Val Tyr Asn Ala Val Gly Leu Ala
 445                 450                 455                 460

 gct tat gag ctc ttt gac agt gtt gat ttt gat cag tgg ttt aaa aac     1622
 Ala Tyr Glu Leu Phe Asp Ser Val Asp Phe Asp Gln Trp Phe Lys Asn
                 465                 470                 475

 cag ctt ctt cca gaa tta caa gtc att cac aat agg tat aag cca ttg     1670
 Gln Leu Leu Pro Glu Leu Gln Val Ile His Asn Arg Tyr Lys Pro Leu
             480                 485                 490

 cga cgc agg gtg att tgg ctc atc ggt cag tgg gtt tct gtg aaa ttc     1718
 Arg Arg Arg Val Ile Trp Leu Ile Gly Gln Trp Val Ser Val Lys Phe
         495                 500                 505

 aag tct gac tta aga ccc atg ctt tat gaa gca atc tgt aac ttg ctt     1766
 Lys Ser Asp Leu Arg Pro Met Leu Tyr Glu Ala Ile Cys Asn Leu Leu
     510                 515                 520

 caa gat caa gat tta gtg gtc cgt att gaa aca gct aca act ttg aag     1814
 Gln Asp Gln Asp Leu Val Val Arg Ile Glu Thr Ala Thr Thr Leu Lys
 525                 530                 535                 540

 tta act gtt gat gat ttt gaa ttt aga aca gat cag ttt cta ccg tat     1862
 Leu Thr Val Asp Asp Phe Glu Phe Arg Thr Asp Gln Phe Leu Pro Tyr
                 545                 550                 555

 ttg gaa acc atg ttc aca cta ctt ttt cag tta ctg cag caa gct aca     1910
 Leu Glu Thr Met Phe Thr Leu Leu Phe Gln Leu Leu Gln Gln Ala Thr
             560                 565                 570

 gaa tgt gac aca aag atg cat gtt ttg cat gtc ctt tct tgt gtg atc     1958
 Glu Cys Asp Thr Lys Met His Val Leu His Val Leu Ser Cys Val Ile
         575                 580                 585

 gaa aga gtc aac atg cag ata cga cca tat gtg gga tgt ttg gta caa     2006
 Glu Arg Val Asn Met Gln Ile Arg Pro Tyr Val Gly Cys Leu Val Gln
     590                 595                 600

 tat ttg ccc ctc ctt tgg aag cag agt gaa gaa cac aat atg ttg aga     2054
 Tyr Leu Pro Leu Leu Trp Lys Gln Ser Glu Glu His Asn Met Leu Arg
 605                 610                 615                 620

 tgt gct att ttg aca aca ctt att cat ctt gtt cag gga tta gga gca     2102
 Cys Ala Ile Leu Thr Thr Leu Ile His Leu Val Gln Gly Leu Gly Ala
                 625                 630                 635

 gac agc aag aac ctg tac cct ttc ctg ctc cca gtt att caa ctg agt     2150
 Asp Ser Lys Asn Leu Tyr Pro Phe Leu Leu Pro Val Ile Gln Leu Ser
             640                 645                 650

 aca gat gtt tca cag cct cca cat gtt tat ctt ctg gaa gat ggt tta     2198
 Thr Asp Val Ser Gln Pro Pro His Val Tyr Leu Leu Glu Asp Gly Leu
         655                 660                 665

 gaa tta tgg tta gta act ttg gaa aac agt cca tgt att aca cca gag     2246
 Glu Leu Trp Leu Val Thr Leu Glu Asn Ser Pro Cys Ile Thr Pro Glu
     670                 675                 680

 ttg ctt cgt ata ttt cag aat atg tca cca ctt ctt gaa cta agt tca     2294
 Leu Leu Arg Ile Phe Gln Asn Met Ser Pro Leu Leu Glu Leu Ser Ser
 685                 690                 695                 700

 gaa aat ctt aga act tgc ttt aag atc atc aat ggt tat atc ttt tta     2342
 Glu Asn Leu Arg Thr Cys Phe Lys Ile Ile Asn Gly Tyr Ile Phe Leu
                 705                 710                 715

 tca tca aca gaa ttt tta cag aca tac gca gta ggt cta tgc cag tcc     2390
 Ser Ser Thr Glu Phe Leu Gln Thr Tyr Ala Val Gly Leu Cys Gln Ser
             720                 725                 730

 ttt tgt gaa ctt tta aag gaa att act aca gaa ggt caa gtt cag gtg     2438
 Phe Cys Glu Leu Leu Lys Glu Ile Thr Thr Glu Gly Gln Val Gln Val
         735                 740                 745

 ctc aag gtt gtg gaa aat gcc ctt aaa gtg aac cca ata cta ggt cca     2486
 Leu Lys Val Val Glu Asn Ala Leu Lys Val Asn Pro Ile Leu Gly Pro
     750                 755                 760

 caa atg ttt caa ccg att tta ccc tat gtt ttc aag ggt att ata gaa     2534
 Gln Met Phe Gln Pro Ile Leu Pro Tyr Val Phe Lys Gly Ile Ile Glu
 765                 770                 775                 780

 ggg gag agg tat cct gta gtg atg tcc acg tat ctt gga gtt atg ggt     2582
 Gly Glu Arg Tyr Pro Val Val Met Ser Thr Tyr Leu Gly Val Met Gly
                 785                 790                 795

 cga gtt cta cta caa aac act agt ttt ttt tct tca cta ctt aat gag     2630
 Arg Val Leu Leu Gln Asn Thr Ser Phe Phe Ser Ser Leu Leu Asn Glu
             800                 805                 810

 atg gcc cat aaa ttt aat cag gag atg gac cag ctt ttg gga aat atg     2678
 Met Ala His Lys Phe Asn Gln Glu Met Asp Gln Leu Leu Gly Asn Met
         815                 820                 825

 att gaa atg tgg gtt gat cga atg gac aac att acc cag cct gaa aga     2726
 Ile Glu Met Trp Val Asp Arg Met Asp Asn Ile Thr Gln Pro Glu Arg
     830                 835                 840

 aga aaa ctt tca gct ttg gct ttg ctc tct ctt ctg cca tct gat aat     2774
 Arg Lys Leu Ser Ala Leu Ala Leu Leu Ser Leu Leu Pro Ser Asp Asn
 845                 850                 855                 860

 agt gtt atc caa gat aaa ttc tgt ggg att ata aac att tca gta gaa     2822
 Ser Val Ile Gln Asp Lys Phe Cys Gly Ile Ile Asn Ile Ser Val Glu
                 865                 870                 875

 ggc ctg cat gat gtc atg acg gaa gat cct gaa aca gga act tat aaa     2870
 Gly Leu His Asp Val Met Thr Glu Asp Pro Glu Thr Gly Thr Tyr Lys
             880                 885                 890

 gac tgt atg ttg atg tct cat ctt gag gaa cca aaa gta aca gaa gat     2918
 Asp Cys Met Leu Met Ser His Leu Glu Glu Pro Lys Val Thr Glu Asp
         895                 900                 905

 gaa gaa cca ccc aca gaa caa gat aag agg aaa aag atg ctg gcc ctg     2966
 Glu Glu Pro Pro Thr Glu Gln Asp Lys Arg Lys Lys Met Leu Ala Leu
     910                 915                 920

 aag gac cct gtt cat aca gtg tca ctg cag cag ttc atc tac gag aag     3014
 Lys Asp Pro Val His Thr Val Ser Leu Gln Gln Phe Ile Tyr Glu Lys
 925                 930                 935                 940

 ctc aag gca cag cag gag atg cta gga gaa caa ggt ttc cag tcc ctc     3062
 Leu Lys Ala Gln Gln Glu Met Leu Gly Glu Gln Gly Phe Gln Ser Leu
                 945                 950                 955

 atg gaa aca gtg gat acg gag att gtc acc cag cta cag gag ttt ttg     3110
 Met Glu Thr Val Asp Thr Glu Ile Val Thr Gln Leu Gln Glu Phe Leu
             960                 965                 970

 caa gga ttc taa                                                     3122
 Gln Gly Phe 
         975





      <210> 436
      <211> 4834
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (159)..(3431)

      <400> 436
 gagccccgca tcccgccgca gctgccgcct cgccgcggcc gggccggaga gcacggcggc     60

 gggagcgcgg ccttaggagg cggccggagc ggtgggcaca gctcggcgcg gagcgtcctg    120

 tcaggcggcg gccgagggcg tcgcggactc tccccgcg    atg atg ccg atg ata     173
                                              Met Met Pro Met Ile
                                                1               5

 tta act gtt ttc ttg agc aac aat gaa cag att tta aca gaa gtt cct      221
 Leu Thr Val Phe Leu Ser Asn Asn Glu Gln Ile Leu Thr Glu Val Pro
                  10                  15                  20

 ata aca ccg gaa aca acc tgt cga gat gtt gta gaa ttt tgc aag gaa      269
 Ile Thr Pro Glu Thr Thr Cys Arg Asp Val Val Glu Phe Cys Lys Glu
              25                  30                  35

 cct gga gaa ggc agc tgc cat tta gct gaa gtg tgg agg gga aat gaa      317
 Pro Gly Glu Gly Ser Cys His Leu Ala Glu Val Trp Arg Gly Asn Glu
          40                  45                  50

 cgt ccc ata ccc ttt gat cat atg atg tac gaa cat ctt cag ata tgg      365
 Arg Pro Ile Pro Phe Asp His Met Met Tyr Glu His Leu Gln Ile Trp
      55                  60                  65

 ggt cca cgg agg gaa gaa gtg aaa ttt ttc ctt cga cac gag gac tcc      413
 Gly Pro Arg Arg Glu Glu Val Lys Phe Phe Leu Arg His Glu Asp Ser
  70                  75                  80                  85

 cca act gag aac agt gaa caa ggt ggc cgt cag acc caa gag caa cga      461
 Pro Thr Glu Asn Ser Glu Gln Gly Gly Arg Gln Thr Gln Glu Gln Arg
                  90                  95                 100

 act cag aga aat gta ata aat gta cct gga gat aaa cgt act gaa tat      509
 Thr Gln Arg Asn Val Ile Asn Val Pro Gly Asp Lys Arg Thr Glu Tyr
             105                 110                 115

 ggg gtt ggg tat cca cgt gta gaa ctt acc ctc tca gag ctc caa gat      557
 Gly Val Gly Tyr Pro Arg Val Glu Leu Thr Leu Ser Glu Leu Gln Asp
         120                 125                 130

 atg gca gct agg caa cag cag cag att gaa aat cag cag cag atg ttg      605
 Met Ala Ala Arg Gln Gln Gln Gln Ile Glu Asn Gln Gln Gln Met Leu
     135                 140                 145

 gtt gcc aag gaa cag cgt tta cat ttt cta aag caa cag gag cgc cgt      653
 Val Ala Lys Glu Gln Arg Leu His Phe Leu Lys Gln Gln Glu Arg Arg
 150                 155                 160                 165

 cag cag cag tct att tct gaa aat gaa aag ctt cag aaa ttg aaa gaa      701
 Gln Gln Gln Ser Ile Ser Glu Asn Glu Lys Leu Gln Lys Leu Lys Glu
                 170                 175                 180

 cga gtt gaa gcc cag gag aac aag ctg aag aaa att cgt gca atg aga      749
 Arg Val Glu Ala Gln Glu Asn Lys Leu Lys Lys Ile Arg Ala Met Arg
             185                 190                 195

 gga caa gtc gac tac agc aaa atc atg aac ggc aat ctg tct gct gaa      797
 Gly Gln Val Asp Tyr Ser Lys Ile Met Asn Gly Asn Leu Ser Ala Glu
         200                 205                 210

 ata gaa agg ttc agt gcc atg ttc cag gaa aag aag cag gaa gta cag      845
 Ile Glu Arg Phe Ser Ala Met Phe Gln Glu Lys Lys Gln Glu Val Gln
     215                 220                 225

 act gca att tta agg gtt gat cag ctt agt cag caa ttg gaa gat tta      893
 Thr Ala Ile Leu Arg Val Asp Gln Leu Ser Gln Gln Leu Glu Asp Leu
 230                 235                 240                 245

 aag aaa gga aaa ctg aat ggg ttc cag tct tac aat ggc aaa ttg acg      941
 Lys Lys Gly Lys Leu Asn Gly Phe Gln Ser Tyr Asn Gly Lys Leu Thr
                 250                 255                 260

 gga cca gcg gcg gtg gag tta aaa aga ctg tac caa gaa cta cag att      989
 Gly Pro Ala Ala Val Glu Leu Lys Arg Leu Tyr Gln Glu Leu Gln Ile
             265                 270                 275

 cgt aac caa ctt aac cag gaa caa aat tca aaa ctt cag cag cag aag     1037
 Arg Asn Gln Leu Asn Gln Glu Gln Asn Ser Lys Leu Gln Gln Gln Lys
         280                 285                 290

 gaa ctc tta aat aag cgc aac atg gag gtg gcc atg atg gac aag cga     1085
 Glu Leu Leu Asn Lys Arg Asn Met Glu Val Ala Met Met Asp Lys Arg
     295                 300                 305

 atc agt gaa ctg cgt gaa cgt ctc tat ggg aaa aaa att cag ctg aac     1133
 Ile Ser Glu Leu Arg Glu Arg Leu Tyr Gly Lys Lys Ile Gln Leu Asn
 310                 315                 320                 325

 cgt gtg aat ggc acg tca tca cca cag tcc cct ctg agc aca tcg ggc     1181
 Arg Val Asn Gly Thr Ser Ser Pro Gln Ser Pro Leu Ser Thr Ser Gly
                 330                 335                 340

 agg gtc gct gct gtg ggg cct tat atc cag gtt ccc agt gcc gga agc     1229
 Arg Val Ala Ala Val Gly Pro Tyr Ile Gln Val Pro Ser Ala Gly Ser
             345                 350                 355

 ttt cct gtg ctg ggg gac cct ata aag ccc cag tct ctc agt att gcc     1277
 Phe Pro Val Leu Gly Asp Pro Ile Lys Pro Gln Ser Leu Ser Ile Ala
         360                 365                 370

 tca aat gct gct cat gga aga tcc aaa tcc gct aat gat gga aac tgg     1325
 Ser Asn Ala Ala His Gly Arg Ser Lys Ser Ala Asn Asp Gly Asn Trp
     375                 380                 385

 cca aca tta aaa cag aat tct agc tct tcc gtg aaa cca gtg cag gtg     1373
 Pro Thr Leu Lys Gln Asn Ser Ser Ser Ser Val Lys Pro Val Gln Val
 390                 395                 400                 405

 gcc ggt gca gac tgg aag gat ccg agc gtg gag ggg tct gtc aag cag     1421
 Ala Gly Ala Asp Trp Lys Asp Pro Ser Val Glu Gly Ser Val Lys Gln
                 410                 415                 420

 ggc act gtc tcc agc cag cct gtg ccc ttc tca gca ctg gga ccc acg     1469
 Gly Thr Val Ser Ser Gln Pro Val Pro Phe Ser Ala Leu Gly Pro Thr
             425                 430                 435

 gag aag ccg ggc atc gag att ggt aaa gtg cca cct ccc atc ccg ggt     1517
 Glu Lys Pro Gly Ile Glu Ile Gly Lys Val Pro Pro Pro Ile Pro Gly
         440                 445                 450

 gta ggc aag cag ctg cct cca agc tat ggg aca tac cca agt cct aca     1565
 Val Gly Lys Gln Leu Pro Pro Ser Tyr Gly Thr Tyr Pro Ser Pro Thr
     455                 460                 465

 cct ctg ggt cct ggg tcg aca agc tcc ctg gaa agg agg aag gaa ggc     1613
 Pro Leu Gly Pro Gly Ser Thr Ser Ser Leu Glu Arg Arg Lys Glu Gly
 470                 475                 480                 485

 agc ttg ccc agg ccc agt gca ggc ctg cca agt cga cag agg ccc acc     1661
 Ser Leu Pro Arg Pro Ser Ala Gly Leu Pro Ser Arg Gln Arg Pro Thr
                 490                 495                 500

 ctg ctg ccc gcc aca ggc agc acc ccc cag cca ggc tcc tca caa cag     1709
 Leu Leu Pro Ala Thr Gly Ser Thr Pro Gln Pro Gly Ser Ser Gln Gln
             505                 510                 515

 att cag cag agg att tcc gta ccg cca agt ccc acg tac ccg cca gcg     1757
 Ile Gln Gln Arg Ile Ser Val Pro Pro Ser Pro Thr Tyr Pro Pro Ala
         520                 525                 530

 gga cca cct gca ttt cca gct ggg gac agc aag cct gaa ctc cca ctg     1805
 Gly Pro Pro Ala Phe Pro Ala Gly Asp Ser Lys Pro Glu Leu Pro Leu
     535                 540                 545

 aca gtg gcc att agg cct ttc ctg gct gat aaa ggg tca agg cca cag     1853
 Thr Val Ala Ile Arg Pro Phe Leu Ala Asp Lys Gly Ser Arg Pro Gln
 550                 555                 560                 565

 tct ccc agg aaa gga ccc cag aca gtg aat tca agt tcc ata tac tcc     1901
 Ser Pro Arg Lys Gly Pro Gln Thr Val Asn Ser Ser Ser Ile Tyr Ser
                 570                 575                 580

 atg tac ctc cag caa gcc aca cca cct aag aat tac cag ccg gca gca     1949
 Met Tyr Leu Gln Gln Ala Thr Pro Pro Lys Asn Tyr Gln Pro Ala Ala
             585                 590                 595

 cac agc gcc tta aat aag tca gtt aaa gca gtg tat ggt aag ccc gtt     1997
 His Ser Ala Leu Asn Lys Ser Val Lys Ala Val Tyr Gly Lys Pro Val
         600                 605                 610

 tta cct tcg ggt tca acc tct cca tcg ccg ctg ccg ttt ctt cac ggg     2045
 Leu Pro Ser Gly Ser Thr Ser Pro Ser Pro Leu Pro Phe Leu His Gly
     615                 620                 625

 tca ctg tcc acg ggc aca cca cag cct cag cca cct tca gaa agt act     2093
 Ser Leu Ser Thr Gly Thr Pro Gln Pro Gln Pro Pro Ser Glu Ser Thr
 630                 635                 640                 645

 gag aaa gag cct gag cag gat ggc ccc gcc gcc ccc gca gat ggc agc     2141
 Glu Lys Glu Pro Glu Gln Asp Gly Pro Ala Ala Pro Ala Asp Gly Ser
                 650                 655                 660

 acc gtg gag agc ctg cca cgg cca ctc agc ccc acc aag ctc acg ccc     2189
 Thr Val Glu Ser Leu Pro Arg Pro Leu Ser Pro Thr Lys Leu Thr Pro
             665                 670                 675

 atc gtg cat tcg cca ctg cgc tac cag agt gat gca gac ctg gag gcc     2237
 Ile Val His Ser Pro Leu Arg Tyr Gln Ser Asp Ala Asp Leu Glu Ala
         680                 685                 690

 ctc cgc agg aag ctg gcc aac gcg ccc cgg ccc ctg aaa aag cgc agc     2285
 Leu Arg Arg Lys Leu Ala Asn Ala Pro Arg Pro Leu Lys Lys Arg Ser
     695                 700                 705

 tcc atc aca gag ccc gag ggc ccc ggc ggg ccc aac atc cag aag ctg     2333
 Ser Ile Thr Glu Pro Glu Gly Pro Gly Gly Pro Asn Ile Gln Lys Leu
 710                 715                 720                 725

 ctg tac cag cgc ttc aac acc ctg gcc ggt ggc atg gag ggc acc cct     2381
 Leu Tyr Gln Arg Phe Asn Thr Leu Ala Gly Gly Met Glu Gly Thr Pro
                 730                 735                 740

 ttc tac cag ccc agc ccc tcc cag gac ttc atg ggc acc ttg gcc gat     2429
 Phe Tyr Gln Pro Ser Pro Ser Gln Asp Phe Met Gly Thr Leu Ala Asp
             745                 750                 755

 gtg gac aat gga aac acc aat gcc aat gga aac ctg gaa gag ctc ccc     2477
 Val Asp Asn Gly Asn Thr Asn Ala Asn Gly Asn Leu Glu Glu Leu Pro
         760                 765                 770

 cct gcc cag ccc aca gcc cca ctc ccc gct gag cct gcc ccg tca tca     2525
 Pro Ala Gln Pro Thr Ala Pro Leu Pro Ala Glu Pro Ala Pro Ser Ser
     775                 780                 785

 gat gcc aat gat aat gag tta cct tcc ccc gaa cca gag gag ctc atc     2573
 Asp Ala Asn Asp Asn Glu Leu Pro Ser Pro Glu Pro Glu Glu Leu Ile
 790                 795                 800                 805

 tgt ccc caa acc acc cac caa act gcc gag ccg gca gag gac aat aac     2621
 Cys Pro Gln Thr Thr His Gln Thr Ala Glu Pro Ala Glu Asp Asn Asn
                 810                 815                 820

 aac aac gtg gcc acg gtc ccc acc acg gag cag atc ccg agt cct gtg     2669
 Asn Asn Val Ala Thr Val Pro Thr Thr Glu Gln Ile Pro Ser Pro Val
             825                 830                 835

 gct gag gcc cca tct cca ggg gaa gag cag gtc cct cca gca cct ctt     2717
 Ala Glu Ala Pro Ser Pro Gly Glu Glu Gln Val Pro Pro Ala Pro Leu
         840                 845                 850

 ccc cct gcc agc cac cct cct gcc acc tcc acg aac aag cgg acc aac     2765
 Pro Pro Ala Ser His Pro Pro Ala Thr Ser Thr Asn Lys Arg Thr Asn
     855                 860                 865

 ttg aag aag ccc aac tcg gag cgg acg ggg cac ggg ctg aga gtc cgg     2813
 Leu Lys Lys Pro Asn Ser Glu Arg Thr Gly His Gly Leu Arg Val Arg
 870                 875                 880                 885

 ttt aac ccc ctg gca ctg ctc cta gac gcg tct ctg gaa gga gag ttc     2861
 Phe Asn Pro Leu Ala Leu Leu Leu Asp Ala Ser Leu Glu Gly Glu Phe
                 890                 895                 900

 gat ctg gtg cag agg atc atc tat gag gtg gaa gat ccc agc aag ccc     2909
 Asp Leu Val Gln Arg Ile Ile Tyr Glu Val Glu Asp Pro Ser Lys Pro
             905                 910                 915

 aac gat gaa ggg atc acc cca ctg cac aac gcc gtc tgc gcc ggc cac     2957
 Asn Asp Glu Gly Ile Thr Pro Leu His Asn Ala Val Cys Ala Gly His
         920                 925                 930

 cat cac atc gtg aag ttc ctg ctg gat ttt ggt gtc aac gtg aat gct     3005
 His His Ile Val Lys Phe Leu Leu Asp Phe Gly Val Asn Val Asn Ala
     935                 940                 945

 gct gat agt gat gga tgg acg ccg ctg cac tgc gct gcc tct tgt aac     3053
 Ala Asp Ser Asp Gly Trp Thr Pro Leu His Cys Ala Ala Ser Cys Asn
 950                 955                 960                 965

 agc gtt cac ctc tgc aaa cag ctg gtg gag agt ggt gcc gcc att ttt     3101
 Ser Val His Leu Cys Lys Gln Leu Val Glu Ser Gly Ala Ala Ile Phe
                 970                 975                 980

 gcc tca acc ata agc gac att gaa act gct gca gac aag tgt gag gag     3149
 Ala Ser Thr Ile Ser Asp Ile Glu Thr Ala Ala Asp Lys Cys Glu Glu
             985                 990                 995

 atg gag gaa ggc tac atc cag tgc tcc cag ttt cta tat ggg gtg cag     3197
 Met Glu Glu Gly Tyr Ile Gln Cys Ser Gln Phe Leu Tyr Gly Val Gln
        1000                1005                1010

 gaa aag ctg ggt gtg atg aac aaa ggt gtg gcg tat gct ctg tgg gac     3245
 Glu Lys Leu Gly Val Met Asn Lys Gly Val Ala Tyr Ala Leu Trp Asp
    1015                1020                1025

 tac gag gcc cag aac agt gac gag ctg tcc ttc cac gaa ggg gac gcc     3293
 Tyr Glu Ala Gln Asn Ser Asp Glu Leu Ser Phe His Glu Gly Asp Ala
1030                1035                1040                1045

 ctc acc atc ctg agg cgc aag gac gaa agc gag act gag tgg tgg tgg     3341
 Leu Thr Ile Leu Arg Arg Lys Asp Glu Ser Glu Thr Glu Trp Trp Trp
                1050                1055                1060

 gct cgc ctt gga gac cgg gag ggc tat gtg ccc aaa aac ctg ctg ggg     3389
 Ala Arg Leu Gly Asp Arg Glu Gly Tyr Val Pro Lys Asn Leu Leu Gly
            1065                1070                1075

 ctg tat cca cgg atc aaa ccc cga cag cga aca ctc gcc tga acttcct     3438
 Leu Tyr Pro Arg Ile Lys Pro Arg Gln Arg Thr Leu Ala 
        1080                1085                1090

 tttggagcac cgcatggtct tgccagctac caggagccac ttaagagatt attgtgctgt   3498

 tttccaggaa agctgcagct agaaaatggt cttaatggtg ctcactttag cagacagcgt   3558

 ccacaatgtg aatcctacag tttccaggtg aggccctttc tccagtttgc ccattaactg   3618

 ggagaggtac tttcgcctcc aaggactgaa ttttgccaat tactataaat ccaaataaat   3678

 acccactttc aaaacaccca cccctcttgc cattaagaag tcccataacc cccggttggt   3738

 tgccagtgaa gacagaagct cttactgact tggccccgag gccatcaccc cctccagcag   3798

 tgaacactgt ccgccgctgt gaggcctgct cccctgcgac cgccctgccc cccgtcaccg   3858

 aatcggacac tcatcctttc tcacacttcc cacacatgat ccttcttccc ttcatcacca   3918

 aaggagcctc tgtatggaaa catgtccagt gttgctgccc agtgtgtatg cctcccagta   3978

 cccactctgc tcggccgcct tgggggttcc gcttcctgtt ccagttcacc taaaggctga   4038

 ttgtgcaggc ccagcactgt ggctggactg ccgcgccacg ggcaccagga cccctaagac   4098

 caagtgacaa ctgggagagc ctcagcatat actcttctcc tccgatctca cagcctgtca   4158

 tgctgctcag tgtggttctc acccctgcaa gctcaaattc agttccctga atggagtcag   4218

 gtgctggagg ccgtggcagc ggagggtggt tggggttggg gctgggggtg gactggtgtg   4278

 agggcagacc agggccaggt agacggggct gtttggtgcc tgaaggatgg cagacgcctg   4338

 gtgtcaggag gggccgccac caaggagcag cagctggggc agaggagctg gggtcagggg   4398

 ccacccctct ctgccgatct ccctgcctgg gctggctgtg aggccacctt tgtcccaggc   4458

 ccagcctcaa ggcaaggagg gcgcttcact gaggtgtgaa ttgtacgtac aggcttttta   4518

 tataccaaaa gtattttttg actagaccat tcaaagctac ccgaactatg ttggaaattt   4578

 ttttttttct cattaaaata caggccctta ggctctattt ttcatgtatg agtcgtgtgt   4638

 aatttatgta aaaatgtgtg tacagactca ctgatgcagc actgtagccc atcaccttgg   4698

 agcactgact gtacatagtg tggtgaagaa aagtgaacgc ccttgtagag cagcccgacc   4758

 acaggagcat ggccgctgcc agcccagacg ctgctgacgc tgtgtaaatg tgcacaataa   4818

 acccgtctca ccccgg                                                   4834




      <210> 437
      <211> 936
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(319)

      <400> 437
 aaatattgcg atgacaagat ataataattt tatgtcactt attagatttt taaccataaa     60

 tgccgtaggc atgctataat atgtattcct tacttttctt tctagaacta aatctccata    120

 cccacttcat ccgtgttttt ggctt  atg tat ggg atg cta gaa tgg cct atc     172
                              Met Tyr Gly Met Leu Glu Trp Pro Ile
                                1               5

 tcc atg tat ttt gtt gca ttt ctc cat tgc ttc ttg tgt tct ggc ggg      220
 Ser Met Tyr Phe Val Ala Phe Leu His Cys Phe Leu Cys Ser Gly Gly
  10                  15                  20                  25

 aat ctt ggt gat tct ttt caa gca cta cct gag ctc tgt gcc aat tgt      268
 Asn Leu Gly Asp Ser Phe Gln Ala Leu Pro Glu Leu Cys Ala Asn Cys
                  30                  35                  40

 tcc tct tct ccc agg gtg ttg tgc tgc gtg gtc atg tct cca ctt cct      316
 Ser Ser Ser Pro Arg Val Leu Cys Cys Val Val Met Ser Pro Leu Pro
              45                  50                  55

 tag ccct gtccattgac agaaccttgg gttctgtgat ggctgcctct aaacccttgt      373
 


 gaaagcgggg aatattcctc cccctgctgc tacagttgag caccgtgctg ggtaccatgt    433

 tgccctctac acttgctttc agttgttaag gcttcccaag ctttggctgt ggctcagtga    493

 tcctgctgtc aaaaccctga aactttccta gcctggacac tcagtggtag cagcaggtgt    553

 tgggatttct ccaagcccct aagactctgg gaggaagaga atggctgttt gacatagacc    613

 tcaggagttt tcaaagcacc aagaaacctc tccagaagat atgtaaaggt aagattctga    673

 tttctctagg aagccgttct agaagctaaa aacaaaaccc tgtagctatg gatttaatat    733

 aagttagtag ttaaagaatg tccttgggaa actctgtgtt tgatcaaacc aaaatatgag    793

 tcttagggaa ctatttatta aaaactctta taggaatttt gtgtgagatt cacattagtt    853

 ttatttatat taaatttggc atggaacaga tttttaaata ttcaattttt tttattcgga    913

 ctctgtgaag cactttttca caa                                            936




      <210> 438
      <211> 3378
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (236)..(1375)

      <400> 438
 gaccggaggc aggaggggag agagagagag agagagccca gagggaggaa gattccacac     60

 gacagtcaag agctcagtat ggctctttta caggtggctt tcctggggga atgcctggta    120

 attttcccgg aggaatgcct ggaatgggag ggccttctgc gcggtcacgc cgagccagcg    180

 cctgggcctg gaaccgggcc gtagcccccc cagtttcgcc caccacctcc ctacc atg     238
                                                              Met
                                                                1

 gac ccc cgc aaa gtg aac gag ctt cgg gcc ttt gtg aaa atg tgt aag      286
 Asp Pro Arg Lys Val Asn Glu Leu Arg Ala Phe Val Lys Met Cys Lys
               5                  10                  15

 cag gat ccg agc gtt ctg cac acc gag gaa atg cgc ttc ctg agg gag      334
 Gln Asp Pro Ser Val Leu His Thr Glu Glu Met Arg Phe Leu Arg Glu
          20                  25                  30

 tgg gtg gag agc atg ggt ggt aaa gta cca cct gct act cag aaa gct      382
 Trp Val Glu Ser Met Gly Gly Lys Val Pro Pro Ala Thr Gln Lys Ala
      35                  40                  45

 aaa tca gaa gaa aat acc aag gaa gaa aaa cct gat agt aag aag gtg      430
 Lys Ser Glu Glu Asn Thr Lys Glu Glu Lys Pro Asp Ser Lys Lys Val
  50                  55                  60                  65

 gag gaa gac tta aag gca gac gaa cca tca agt gag gaa agt gat cta      478
 Glu Glu Asp Leu Lys Ala Asp Glu Pro Ser Ser Glu Glu Ser Asp Leu
                  70                  75                  80

 ggt ctt att gtc att ttc tcg act ttg gca gaa att gat aaa gaa ggt      526
 Gly Leu Ile Val Ile Phe Ser Thr Leu Ala Glu Ile Asp Lys Glu Gly
              85                  90                  95

 gtg att gaa cca gac act gat gct cct caa gaa atg gga gat gaa aat      574
 Val Ile Glu Pro Asp Thr Asp Ala Pro Gln Glu Met Gly Asp Glu Asn
         100                 105                 110

 gcg gag ata acg gag gag atg atg gat cag gca aat gat aaa aaa gtg      622
 Ala Glu Ile Thr Glu Glu Met Met Asp Gln Ala Asn Asp Lys Lys Val
     115                 120                 125

 gct gct att gaa gcc cta aat gat ggt gaa ctc cag aaa gcc att gac      670
 Ala Ala Ile Glu Ala Leu Asn Asp Gly Glu Leu Gln Lys Ala Ile Asp
 130                 135                 140                 145

 tta ttc aca gat gcc atc aag ctg aat cct cgc ttg gcc att ttg tat      718
 Leu Phe Thr Asp Ala Ile Lys Leu Asn Pro Arg Leu Ala Ile Leu Tyr
                 150                 155                 160

 gcc aag agg gcc agt gtc ttc gtc aaa tta cag aag cca aat gct gcc      766
 Ala Lys Arg Ala Ser Val Phe Val Lys Leu Gln Lys Pro Asn Ala Ala
             165                 170                 175

 atc cga gac tgt gac aga gcc att gaa ata aat cct gat tca gct cag      814
 Ile Arg Asp Cys Asp Arg Ala Ile Glu Ile Asn Pro Asp Ser Ala Gln
         180                 185                 190

 cct tac aag tgg cgg ggg aaa gca cac aga ctt cta ggc cac tgg gaa      862
 Pro Tyr Lys Trp Arg Gly Lys Ala His Arg Leu Leu Gly His Trp Glu
     195                 200                 205

 gaa gca gcc cat gat ctt gcc ctt gcc tgt aaa ttg gat tat gat gaa      910
 Glu Ala Ala His Asp Leu Ala Leu Ala Cys Lys Leu Asp Tyr Asp Glu
 210                 215                 220                 225

 gat gct agt gca atg ctg aaa gaa gtt caa cct agg gca cag aaa att      958
 Asp Ala Ser Ala Met Leu Lys Glu Val Gln Pro Arg Ala Gln Lys Ile
                 230                 235                 240

 gca gaa cat cgg aga aag tat gag cga aaa cgt gaa gag cga gag atc     1006
 Ala Glu His Arg Arg Lys Tyr Glu Arg Lys Arg Glu Glu Arg Glu Ile
             245                 250                 255

 aaa gaa aga ata gaa cga gtt aag aag gct cga gaa gag cat gag aga     1054
 Lys Glu Arg Ile Glu Arg Val Lys Lys Ala Arg Glu Glu His Glu Arg
         260                 265                 270

 gcc cag agg gag gaa gaa gcc aga cga cag tca gga gct cag tat ggc     1102
 Ala Gln Arg Glu Glu Glu Ala Arg Arg Gln Ser Gly Ala Gln Tyr Gly
     275                 280                 285

 tct ttt cca ggt ggc ttt cct ggg gga atg cct ggt aat ttt ccc gga     1150
 Ser Phe Pro Gly Gly Phe Pro Gly Gly Met Pro Gly Asn Phe Pro Gly
 290                 295                 300                 305

 gga atg cct gga atg gga ggg ggc atg cct gga atg gct gga atg cct     1198
 Gly Met Pro Gly Met Gly Gly Gly Met Pro Gly Met Ala Gly Met Pro
                 310                 315                 320

 gga ctc aat gaa att ctt agt gat cca gag gtt ctt gca gcc atg cag     1246
 Gly Leu Asn Glu Ile Leu Ser Asp Pro Glu Val Leu Ala Ala Met Gln
             325                 330                 335

 gat cca gaa gtt atg gtg gct ttc cag gat gtg gct cag aac cca gca     1294
 Asp Pro Glu Val Met Val Ala Phe Gln Asp Val Ala Gln Asn Pro Ala
         340                 345                 350

 aat atg tca aaa tac cag agc aac cca aag gtt atg aat ctc atc agt     1342
 Asn Met Ser Lys Tyr Gln Ser Asn Pro Lys Val Met Asn Leu Ile Ser
     355                 360                 365

 aaa ttg tca gcc aaa ttt gga ggt caa gcg taa tgtccttc tgataaataa     1393
 Lys Leu Ser Ala Lys Phe Gly Gly Gln Ala 
 370                 375

 agcccttgct gaaggaaaag caacctagat caccttatgg atgtcgcaat aatacaaacc   1453

 agtgtacctc tgaccttctc atcaagagag ctggggtgct ttgaagataa tccctacccc   1513

 tctcccccaa atgcagctga agcattttac agtggtttgc cattagggta ttcattcaga   1573

 taatgttttc ctactaggaa ttacaaactt taaacacttt ttaaatcttc aaaatattta   1633

 aaacaaattt aaagggcctg ttaattctta tatttttctt tactaatcat tttggatttt   1693

 tttctttgaa ttattggcag ggaatatact tatgtatgga agattactgc tctgagtgaa   1753

 ataaaagtta ttagtgcgag gcaaacataa ctcatttgag gataaagttt gtgttggata   1813

 tgtggttcct gatgcatttt gacttgtctt tttaaatgct ttatcttttt ctttaaagat   1873

 ttatttcaat aaaactaatt gggaccaccc gtatttcagt aggacctggg tagggattgg   1933

 aagtacttgg cagggcagca gcaatcttgc tgtgtttgat ataacatgca tccttgggca   1993

 ggttgccctt aaatcttaca ctgtggtgaa gggatgtttt ttttgtaatg ctgcagtaga   2053

 gttggagtac ttagttctct tgttgtccag tatatctaat aagtgttttt catattattt   2113

 ccacgtaagg gaaataaggt agtacttttc tttttatatt tctatgctta aaattctctt   2173

 tcctagtcaa aaattgccca aatctgtgtt tgctttctgc ttgctacatt tgtctccctt   2233

 acttttcttg agctaaagac aggctttttc caccggcatc atcactgcta tcatcattaa   2293

 cagcgtaatt atacaagcat atttaatgct gagtttaatt taatatgtaa tacatatggt   2353

 aattgtaggg taatacccac aacaactgta gtttcttact tggccaagag aatgcttatt   2413

 taagtgttag acttccattc tggcaaaatc ttgccttatc agaagacatt ggaaagaggg   2473

 attccctttg gtgtttggtc ttctacttag aaaaacctat tgcagttagt ttatcttgta   2533

 gtattcatct ttgtattctg aagataaggt ttgaattaaa ttgatacaca cagaggggaa   2593

 ccgatttttt ttatccaatg tgaattataa atgagataat ccacagttat tcattgtgga   2653

 gttgttgaga ctatgaaaga ctcattgtct ttgtattcag ctcttaaata gtgtaactat   2713

 atccccacct ctgcttgctt tctttccctc ccctccaatg ataaagaaaa tgataaattt   2773

 tctgttgtgc attcaattct tattttaaat aagactaagt ataggcattg tacctgacat   2833

 tgctacgttt ctaccagtgt ttcaatttaa agtgctagtg tttaaaaaca ttttcaaggg   2893

 ataaggcctt ctgtactttg cttatttgaa gaatcagtgg taggagcagt gaagtaaatt   2953

 ctatggagta catttctaaa ataccacatt tctgaaatca taaataagtt tattcaggtt   3013

 ctaacccttt gctgtacaca agcagacaga aatgcatctg ttacataaat gagaaaaagc   3073

 tattatgctg atggagcatg ctttttaaat cctttaaaaa cactcaccat ataaacttgc   3133

 atttgagctt gtgtgttctt ttgttaatgt gtagagttct cctttctcga aattgccagt   3193

 gtgtacttgg cttaactcaa gaacagtttc ttctggattc cttatttgat ttatttaacc   3253

 taattatatt ctaatattgc aaatattacc ataagtgggt aaaagtaaaa ttcctcttct   3313

 gaaaatgtgt cctgtgcttt tagattttta aattccataa tatacattct taattttcaa   3373

 ctcaa                                                               3378




      <210> 439
      <211> 1201
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(419)

      <400> 439
 tcccgggtcg acgatttcgt gaaaaaagga ag  atg gca aga ata ttg tta ctt      53
                                      Met Ala Arg Ile Leu Leu Leu
                                        1               5

 ttc ctc ccg ggt ctt gtg gct gta tgt gct gtg cat gga ata ttt atg      101
 Phe Leu Pro Gly Leu Val Ala Val Cys Ala Val His Gly Ile Phe Met
          10                  15                  20

 gac cgt cta gct tcc aag aag ctc tgt gca gat gat gag tgt gtc tat      149
 Asp Arg Leu Ala Ser Lys Lys Leu Cys Ala Asp Asp Glu Cys Val Tyr
      25                  30                  35

 act att tct ctg gct agt gct caa gaa gat tat aat gcc ccg gac tgt      197
 Thr Ile Ser Leu Ala Ser Ala Gln Glu Asp Tyr Asn Ala Pro Asp Cys
  40                  45                  50                  55

 aga ttc att aac gtt aaa aaa ggg cag cag atc tat gtg tac tca aag      245
 Arg Phe Ile Asn Val Lys Lys Gly Gln Gln Ile Tyr Val Tyr Ser Lys
                  60                  65                  70

 ctg gta aaa gaa aat gga gct gga gaa ttt tgg gct ggc agt gtt tat      293
 Leu Val Lys Glu Asn Gly Ala Gly Glu Phe Trp Ala Gly Ser Val Tyr
              75                  80                  85

 ggt gat ggc cag gac gag atg gga gtc gtg ggt tat ttc ccc agg aac      341
 Gly Asp Gly Gln Asp Glu Met Gly Val Val Gly Tyr Phe Pro Arg Asn
          90                  95                 100

 ttg gtc aag gaa cag cgt gtg tac cag gaa gct acc aag gaa gtt ccc      389
 Leu Val Lys Glu Gln Arg Val Tyr Gln Glu Ala Thr Lys Glu Val Pro
     105                 110                 115

 acc acg gat att gac ttc ttc tgc gag taa t aaattagtta aaactgcaaa      440
 Thr Thr Asp Ile Asp Phe Phe Cys Glu 
 120                 125

 tagaaagaaa acaccaaaaa taaagaaaag agcaaaagtg gccaaaaaat gcatgtctgt    500

 aattttggac tgacgtttta agaatttgtt accttacaga agagcaaggg cttaggggtt    560

 ggaggtggca gataaaagag gattttcaac tcaaatcttg tttcctgctg gcctggtctg    620

 cccacgagct agagcgggga aatgttgagc tcaaatgggt aaattgggac cagaaaatta    680

 ttttttcaac ctagagaatc tcctcttaca gggggatgca tataacagat catgtatgtg    740

 tagttatttc taagtagtaa ttcttcccag ctctttgatt tgccatatat agaataggtg    800

 ggtcgtatgt cttcccttta gacatgatgt tttctactca tttgtctctc tggccaattg    860

 aattattaat aaaaggtctg tattatcaaa gagtattcta gtatttttgt tacttttaat    920

 atttgatgcc ttttggaggt aaagctgttg ggggaagaag agtttttgga cccatagatg    980

 tttggatgat gtctctaatt tgtcatttag aaaaatctca aaaatgattt cagttgaata   1040

 acttgccttc taaatgatca atttacttct cccccaattt taaagaagta tgtgtatatt   1100

 taatagggga aggtagttta tggaaatatt tttaatggaa tagttttccc ttaatatgta   1160

 tccttgctgg atattattca agctgcaagt catcaaaaga c                       1201




      <210> 440
      <211> 1075
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (244)..(978)

      <400> 440
 ggcgcgcgag agctgctagg gcggtttctc tgcctcgggc ctgttgggca gggccggcta     60

 aggtgcgcgt gctcgctggt tctaaccctt ctgttgggcg tttctgctga gaggcgggag    120

 gcgccgagag tctgtgcgaa ggtccgtgga cagactgctt tgcctgttgt tgctcttcgg    180

 aggcggcgat ccccgaaggc gagctgaaat acggctgcag gctacaattt gcagccgacc    240

 att  atg gat gac aag gag ccg aag agg tgg ccc acc ctc agg gac cgc     288
      Met Asp Asp Lys Glu Pro Lys Arg Trp Pro Thr Leu Arg Asp Arg
        1               5                  10                  15

 ttg tgc tcg gat ggc ttc tta ttt ccc caa tac ccc att aaa ccg tat      336
 Leu Cys Ser Asp Gly Phe Leu Phe Pro Gln Tyr Pro Ile Lys Pro Tyr
                  20                  25                  30

 cat ctg aag ggg atc cac aga gct gtc ttc tat cgt gat ctg gag gaa      384
 His Leu Lys Gly Ile His Arg Ala Val Phe Tyr Arg Asp Leu Glu Glu
              35                  40                  45

 ctg aag ttc gtt ctg ctc acg cgt tat gac atc aat aag aga gac agg      432
 Leu Lys Phe Val Leu Leu Thr Arg Tyr Asp Ile Asn Lys Arg Asp Arg
          50                  55                  60

 aag gaa agg acc gcc cta cat ttg gcc tgt gcc act ggc caa ccg gaa      480
 Lys Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu
      65                  70                  75

 atg gta cat ctc ctg gtg tcc aga aga tgt gag ctt aac ctc tgc gac      528
 Met Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp
  80                  85                  90                  95

 cgt gaa gac agg aca cct ctg atc aag gct gta caa ctg agg cag gag      576
 Arg Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu
                 100                 105                 110

 gct tgt gca act ctt ctg ctg caa aat ggc gcc gat cca aat att acg      624
 Ala Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asp Pro Asn Ile Thr
             115                 120                 125

 gat gtc ttt gga agg act gct ctg cac tac gct gtg tat aat gaa gat      672
 Asp Val Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp
         130                 135                 140

 aca tcc atg ata gaa aaa ctt ctt tca tat ggt gca aat att gaa gaa      720
 Thr Ser Met Ile Glu Lys Leu Leu Ser Tyr Gly Ala Asn Ile Glu Glu
     145                 150                 155

 tgc agc gag gat gaa tat ccg cca ctg ttc ctt gct gtg agt caa aga      768
 Cys Ser Glu Asp Glu Tyr Pro Pro Leu Phe Leu Ala Val Ser Gln Arg
 160                 165                 170                 175

 aaa gtg aaa atg gtg gaa ttt tta tta aag aaa aaa gca aat ata aat      816
 Lys Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Ile Asn
                 180                 185                 190

 gcc gtt gat tat ctt ggc aga tca gcc ctc ata cat gct gtt act ctt      864
 Ala Val Asp Tyr Leu Gly Arg Ser Ala Leu Ile His Ala Val Thr Leu
             195                 200                 205

 gga gaa aaa gat ata gtc att ctt ctt ctg cag cac aat att gat gtg      912
 Gly Glu Lys Asp Ile Val Ile Leu Leu Leu Gln His Asn Ile Asp Val
         210                 215                 220

 ttt tct cga gat gtg tat gga aag ctt gca gaa gat tat gcc agc gag      960
 Phe Ser Arg Asp Val Tyr Gly Lys Leu Ala Glu Asp Tyr Ala Ser Glu
     225                 230                 235

 gct aag aac aga gtg taa gtcttt acataaaaag gctaatgaac actaaattga     1014
 Ala Lys Asn Arg Val 
 240

 agtttaaaat aattgtagca attgcatctt atatatcagg tgagattgca tagtttgatt   1074

 c                                                                   1075




      <210> 441
      <211> 1347
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (244)..(1167)

      <400> 441
 ggcgcgcgag agctgctagg gcggtttctc tgcctcgggc ctgttgggca gggccggcta     60

 aggtgcgcgt gctcgctggt tctaaccctt ctgttgggcg tttctgctga gaggcgggag    120

 gcgccgagag tctgtgcgaa ggtccgtgga cagactgctt tgcctgttgt tgctcttcgg    180

 aggcggcgat ccccgaaggc gagctgaaat acggctgcag gctacaattt gcagccgacc    240

 att  atg gat gac aag gag ccg aag agg tgg ccc acc ctc agg gac cgc     288
      Met Asp Asp Lys Glu Pro Lys Arg Trp Pro Thr Leu Arg Asp Arg
        1               5                  10                  15

 ttg tgc tcg gat ggc ttc tta ttt ccc caa tac ccc att aaa ccg tat      336
 Leu Cys Ser Asp Gly Phe Leu Phe Pro Gln Tyr Pro Ile Lys Pro Tyr
                  20                  25                  30

 cat ctg aag ggg atc cac aga gct gtc ttc tat cgt gat ctg gag gaa      384
 His Leu Lys Gly Ile His Arg Ala Val Phe Tyr Arg Asp Leu Glu Glu
              35                  40                  45

 ctg aag ttc gtt ctg ctc acg cgt tat gac atc aat aag aga gac agg      432
 Leu Lys Phe Val Leu Leu Thr Arg Tyr Asp Ile Asn Lys Arg Asp Arg
          50                  55                  60

 aag gaa agg acc gcc cta cat ttg gcc tgt gcc act ggc caa ccg gaa      480
 Lys Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu
      65                  70                  75

 atg gta cat ctc ctg gtg tcc aga aga tgt gag ctt aac ctc tgc gac      528
 Met Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp
  80                  85                  90                  95

 cgt gaa gac agg aca cct ctg atc aag gct gta caa ctg agg cag gag      576
 Arg Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu
                 100                 105                 110

 gct tgt gca act ctt ctg ctg caa aat ggc gcc gat cca aat att acg      624
 Ala Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asp Pro Asn Ile Thr
             115                 120                 125

 gat gtc ttt gga agg act gct ctg cac tac gct gtg tat aat gaa gat      672
 Asp Val Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp
         130                 135                 140

 aca tcc atg ata gaa aaa ctt ctt tca tat ggt gca aat att gaa gaa      720
 Thr Ser Met Ile Glu Lys Leu Leu Ser Tyr Gly Ala Asn Ile Glu Glu
     145                 150                 155

 tgc agc gag gat gaa tat ccg cca ctg ttc ctt gct gtg agt caa aga      768
 Cys Ser Glu Asp Glu Tyr Pro Pro Leu Phe Leu Ala Val Ser Gln Arg
 160                 165                 170                 175

 aaa gtg aaa atg gtg gaa ttt tta tta aag aaa aaa gca aat ata aat      816
 Lys Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Ile Asn
                 180                 185                 190

 gcc gtt gat tat ctt ggc agc att ttt gaa cta att tat gaa tat gaa      864
 Ala Val Asp Tyr Leu Gly Ser Ile Phe Glu Leu Ile Tyr Glu Tyr Glu
             195                 200                 205

 aga aag aaa cat gaa gag ctt tct ata aat agc aat cca gtg tct tct      912
 Arg Lys Lys His Glu Glu Leu Ser Ile Asn Ser Asn Pro Val Ser Ser
         210                 215                 220

 cag aaa caa cca gcc ttg aag gct aca agt ggc aag gaa gat tct atc      960
 Gln Lys Gln Pro Ala Leu Lys Ala Thr Ser Gly Lys Glu Asp Ser Ile
     225                 230                 235

 tcg aat ata gcc aca gaa ata aag gat gga caa aaa tct ggg aca gtg     1008
 Ser Asn Ile Ala Thr Glu Ile Lys Asp Gly Gln Lys Ser Gly Thr Val
 240                 245                 250                 255

 tct tct cag aaa caa ccg gcc ttg aag ggt aca agt gac aag aac gat     1056
 Ser Ser Gln Lys Gln Pro Ala Leu Lys Gly Thr Ser Asp Lys Asn Asp
                 260                 265                 270

 tct gtt tcg aac aca gcc aca gaa ata aaa gat gaa caa aaa tct ggg     1104
 Ser Val Ser Asn Thr Ala Thr Glu Ile Lys Asp Glu Gln Lys Ser Gly
             275                 280                 285

 aca gtg tct tct cag aaa caa ccg gcc ttg aag gta tta tac tct cat     1152
 Thr Val Ser Ser Gln Lys Gln Pro Ala Leu Lys Val Leu Tyr Ser His
         290                 295                 300

 tca tat ttt gaa taa ttaactgtat agtctatgaa atatacttta ggtattgatt     1207
 Ser Tyr Phe Glu 
     305

 attttgtttg aaatcccatt caggatacaa gtgacaagaa cgattctgtt tcgaacacag   1267

 ccacagaaat aaaagatgaa caaaaatctg ggacaggtaa ttttgcaata cacatttaat   1327

 gccatgtaca ctgaagatag                                               1347




      <210> 442
      <211> 258
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(258)

      <400> 442
  atg gaa tct agc tct gtc gac cag agt gga gtg cag tgg cgc gat ctc      48
  Met Glu Ser Ser Ser Val Asp Gln Ser Gly Val Gln Trp Arg Asp Leu
    1               5                  10                  15

 ggc tca ccc ggg ttc aag aga ttc tcc tgt ctc agc ctc ccg agt agc       96
 Gly Ser Pro Gly Phe Lys Arg Phe Ser Cys Leu Ser Leu Pro Ser Ser
              20                  25                  30

 tgg gac tac agg cgt ggg cca cca tgc ctg gat aat ttt tgt att ttt      144
 Trp Asp Tyr Arg Arg Gly Pro Pro Cys Leu Asp Asn Phe Cys Ile Phe
          35                  40                  45

 cac cat gtt ggc cag gct ggt ctc gag ctc ctg acc tca ggt gat ttg      192
 His His Val Gly Gln Ala Gly Leu Glu Leu Leu Thr Ser Gly Asp Leu
      50                  55                  60

 cct gcc tca gcc tcc caa agt gct ggg act aaa cgc gtg agc cac cac      240
 Pro Ala Ser Ala Ser Gln Ser Ala Gly Thr Lys Arg Val Ser His His
  65                  70                  75                  80

 acc cgg ccc aag tct taa                                              258
 Thr Arg Pro Lys Ser 
                  85





      <210> 443
      <211> 484
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(474)

      <400> 443
 gccgggtggt tcctctggag attaaatgta cttcacagaa cctcagcgag cggactccag     60

 ttatattccg tgctcttgtc ggcacgcatt tcacttctag gactgggccg gggtctgcag    120

 ggctcagctg agcccatgag ctcccagagc taacccctga acacccaggc gggcaaaggg    180

 ctg  atg tcg gta gtc ccc atc ctg gag ggg cag gct ctg cgc atc tgc     228
      Met Ser Val Val Pro Ile Leu Glu Gly Gln Ala Leu Arg Ile Cys
        1               5                  10                  15

 tcc tgg cat ggc gct gcg gca cct cgc cct cct ggc tgg cct tct cgt      276
 Ser Trp His Gly Ala Ala Ala Pro Arg Pro Pro Gly Trp Pro Ser Arg
                  20                  25                  30

 ggg agt cgc cag caa gtc cat gga gaa cac gga cca gct gcc cga gtg      324
 Gly Ser Arg Gln Gln Val His Gly Glu His Gly Pro Ala Ala Arg Val
              35                  40                  45

 ctg tgt gga tgt ggt ggg cgt caa cgc cag ctg ccc agg cgc aag tct      372
 Leu Cys Gly Cys Gly Gly Arg Gln Arg Gln Leu Pro Arg Arg Lys Ser
          50                  55                  60

 gtg tgg tcc agg ctg tta cag gcg ctg gaa cgc gga cgg gag cgc cag      420
 Val Trp Ser Arg Leu Leu Gln Ala Leu Glu Arg Gly Arg Glu Arg Gln
      65                  70                  75

 ctg cgt ccg ctg tgg gaa cgg aac cct ccc agc cta caa cgg ctc cga      468
 Leu Arg Pro Leu Trp Glu Arg Asn Pro Pro Ser Leu Gln Arg Leu Arg
  80                  85                  90                  95

 gtg tag aagctttgct                                                   484
 Val 






      <210> 444
      <211> 427
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (10)..(427)

      <400> 444
 cccttcacc    atg gag ctg cct gct gtg aac ctg aag gtg att ctc cta      48
              Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu
                1               5                  10

 ggt cac tgg ctg ctg aca acc tgg ggc tgc att gta ttc tca ggc tcc       96
 Gly His Trp Leu Leu Thr Thr Trp Gly Cys Ile Val Phe Ser Gly Ser
      15                  20                  25

 tat gcc tgg gcc aac ttc acc atc ctg gcc ttg ggc gtg tgg gct gtg      144
 Tyr Ala Trp Ala Asn Phe Thr Ile Leu Ala Leu Gly Val Trp Ala Val
  30                  35                  40                  45

 gct cag cgg gac tcc atc gac gcc ata agc atg ttt ctg ggt ggc ttg      192
 Ala Gln Arg Asp Ser Ile Asp Ala Ile Ser Met Phe Leu Gly Gly Leu
                  50                  55                  60

 ctg gcc acc atc ttc ctg gac atc gtg cac atc agc atc ttc tac ccg      240
 Leu Ala Thr Ile Phe Leu Asp Ile Val His Ile Ser Ile Phe Tyr Pro
              65                  70                  75

 cgg gtc agc ctc acg gac acg ggc cgc ttt ggc gtg ggc atg gcc atc      288
 Arg Val Ser Leu Thr Asp Thr Gly Arg Phe Gly Val Gly Met Ala Ile
          80                  85                  90

 ctc agc ttg ctg ctc aag ccg ctc tcc tgc tgc ttc gtc tac cac atg      336
 Leu Ser Leu Leu Leu Lys Pro Leu Ser Cys Cys Phe Val Tyr His Met
      95                 100                 105

 tac cgg gag cgc ggg ggt ttc ctt ggg tct tct cag gac cgt agt gcc      384
 Tyr Arg Glu Arg Gly Gly Phe Leu Gly Ser Ser Gln Asp Arg Ser Ala
 110                 115                 120                 125

 tac cag acg att gac tca gca gag gcg ccc gca gat ccc ttt g            427
 Tyr Gln Thr Ile Asp Ser Ala Glu Ala Pro Ala Asp Pro Phe 
                 130                 135





      <210> 445
      <211> 1327
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (185)..(1327)

      <400> 445
 tttcgtgtct gcagcgccga gggaggctgc cagtgcgtga ggaagagagc tagagactgg     60

 acaggggaga cagagcagcg tcggagccgc gcaggggacg ggagtgagag cgggagtgag    120

 agcaggaacg acgcagagcg gccgtcgccg tgcccgggtc tcagggcgcc tggctgaagt    180

 gagc atg gct tca gtg gcc tgg gcc gtc ctc aag gtg ctg ctg ctt ctc     229
      Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu
        1               5                  10                  15

 ccc act cag act tgg agc ccc gta gga gca gga aat cca cct gac tgt      277
 Pro Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys
                  20                  25                  30

 gat gct cca ctg gcc tct gcc ttg cct agg tca tcc ttc agc agc tcc      325
 Asp Ala Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser
              35                  40                  45

 tca gag ctg tcc agc agc cac ggc ccg ggg ttt tca agg ctt aat cga      373
 Ser Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg
          50                  55                  60

 aga gat gga gct ggt ggc tgg acc cca ctt gtg tca aat aaa tac caa      421
 Arg Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln
      65                  70                  75

 tgg ctg caa att gac ctt gga gag aga atg gag gtc act gct gtc gcc      469
 Trp Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala
  80                  85                  90                  95

 acc caa gga gga tat ggg agc tct gac tgg gtg acc agc tac ctc ctg      517
 Thr Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu
                 100                 105                 110

 atg ttc agt gat ggt ggg aga aac tgg aag cag tat cgc cga gaa gaa      565
 Met Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu
             115                 120                 125

 agc atc tgg ggt ttt cca gga aac aca aac gca gac agt gtg gtg cac      613
 Ser Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His
         130                 135                 140

 tac aga ctc cag cct ccc ttt gaa gcc agg ttc ctg cgc ttt ctc cct      661
 Tyr Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro
     145                 150                 155

 tta gcc tgg aac ccc agg ggc agg att ggg atg cgg atc gaa gtg tac      709
 Leu Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr
 160                 165                 170                 175

 gga tgt gca tat aaa tct gag gtg gtt tat ttt gat gga caa agt gct      757
 Gly Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala
                 180                 185                 190

 ctg ctg tat aca ctt gat aaa aaa cct tta aaa cca cta aga gat gtt      805
 Leu Leu Tyr Thr Leu Asp Lys Lys Pro Leu Lys Pro Leu Arg Asp Val
             195                 200                 205

 att tct ttg aaa ttt aaa gcc atg cag agc aat gga att cta ctt cac      853
 Ile Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His
         210                 215                 220

 aga gaa gga caa cat gga aat cac att act ctg gaa tta att aaa gga      901
 Arg Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly
     225                 230                 235

 aag ctt gtc ttt ttt ctt aac tca ggc aat gct aag ctg cct tcc act      949
 Lys Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr
 240                 245                 250                 255

 att gct cct gtg acc ctc acc ctg ggc agc ctg ctg gat gac cag cac      997
 Ile Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His
                 260                 265                 270

 tgg cat tcc gtc ctc atc gag ctc ctc gac acg cag gtc aac ttc acc     1045
 Trp His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr
             275                 280                 285

 gtg gac aaa cac act cat cat ttc caa gca aag gga gat tcc agt aac     1093
 Val Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Asn
         290                 295                 300

 ttg gat ctt aat ttt gag atc agc ttt ggg gga att ccg aca ccc gga     1141
 Leu Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Pro Thr Pro Gly
     305                 310                 315

 aga tcg cgg gca ttc aca cgt aaa agc ttt cat ggg tgt tta gaa aat     1189
 Arg Ser Arg Ala Phe Thr Arg Lys Ser Phe His Gly Cys Leu Glu Asn
 320                 325                 330                 335

 ctt tat tat aat gga gtg gat gtt acc gaa tta gcc aag aaa cac aaa     1237
 Leu Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys
                 340                 345                 350

 cca cag atc ctc atg atg gag ttg gct cat ggg ttg cag gac caa aac     1285
 Pro Gln Ile Leu Met Met Glu Leu Ala His Gly Leu Gln Asp Gln Asn
             355                 360                 365

 ctg aaa ata tct ctg act gtg tgt cac cag acc aca caa tga             1327
 Leu Lys Ile Ser Leu Thr Val Cys His Gln Thr Thr Gln 
         370                 375                 380





      <210> 446
      <211> 5263
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (264)..(4130)

      <400> 446
 cccgagcgct ccagaaagct gcggcgcgag tccgcggggc cgacctcgga gacgcagctg     60

 gggccgggcg cggcttggcg ggagggtctg cagcgccgag ggaggctgcc agtgcgtgag    120

 gaagagagct agagactgga caggggagac agagcagcgt cggagccgcg caggggacgg    180

 gagtgagagc gggagtgaga gcaggaacga cgcagagcgg ccgtcgcctt gcccgggtct    240

 cagggcgcct ggctgaagtg agc    atg gct tca gtg gcc tgg gcc gtc ctc     290
                              Met Ala Ser Val Ala Trp Ala Val Leu
                                1               5

 aag gtg ctg ctg ctt ctc ccc act cag act tgg agc ccc gta gga gca      338
 Lys Val Leu Leu Leu Leu Pro Thr Gln Thr Trp Ser Pro Val Gly Ala
  10                  15                  20                  25

 gga aat cca cct gac tgt gat gct cca ctg gcc tct gcc ttg cct agg      386
 Gly Asn Pro Pro Asp Cys Asp Ala Pro Leu Ala Ser Ala Leu Pro Arg
                  30                  35                  40

 tca tcc ttc agc agc tcc tca gag ctg tcc agc agc cac ggc ccg ggg      434
 Ser Ser Phe Ser Ser Ser Ser Glu Leu Ser Ser Ser His Gly Pro Gly
              45                  50                  55

 ttt tca agg ctt aat cga aga gat gga gct ggt ggc tgg acc cca ctt      482
 Phe Ser Arg Leu Asn Arg Arg Asp Gly Ala Gly Gly Trp Thr Pro Leu
          60                  65                  70

 gtg tca aat aaa tac caa tgg ctg caa att gac ctt gga gag aga atg      530
 Val Ser Asn Lys Tyr Gln Trp Leu Gln Ile Asp Leu Gly Glu Arg Met
      75                  80                  85

 gag gtc act gct gtc gcc acc caa gga gga tat ggg agc tct gac tgg      578
 Glu Val Thr Ala Val Ala Thr Gln Gly Gly Tyr Gly Ser Ser Asp Trp
  90                  95                 100                 105

 gtg acc agc tac ctc ctg atg ttc agt gat ggt ggg aga aac tgg aag      626
 Val Thr Ser Tyr Leu Leu Met Phe Ser Asp Gly Gly Arg Asn Trp Lys
                 110                 115                 120

 cag tat cgc cga gaa gaa agc atc tgg ggt ttt cca gga aac aca aac      674
 Gln Tyr Arg Arg Glu Glu Ser Ile Trp Gly Phe Pro Gly Asn Thr Asn
             125                 130                 135

 gca gac agt gtg gtg cac tac aga ctc cag cct ccc ttt gaa gcc agg      722
 Ala Asp Ser Val Val His Tyr Arg Leu Gln Pro Pro Phe Glu Ala Arg
         140                 145                 150

 ttc ctg cgc ttt ctc cct tta gcc tgg aac cct agg ggc agg att ggg      770
 Phe Leu Arg Phe Leu Pro Leu Ala Trp Asn Pro Arg Gly Arg Ile Gly
     155                 160                 165

 atg cgg atc gaa gtg tac gga tgt gca tat aaa tct gag gtg gtt tat      818
 Met Arg Ile Glu Val Tyr Gly Cys Ala Tyr Lys Ser Glu Val Val Tyr
 170                 175                 180                 185

 ttt gat gga caa agt gct ctg ctg tat aga ctt gat aaa aaa cct tta      866
 Phe Asp Gly Gln Ser Ala Leu Leu Tyr Arg Leu Asp Lys Lys Pro Leu
                 190                 195                 200

 aaa cca ata aga gac gtt att tct ttg aaa ttt aaa gcc atg cag agc      914
 Lys Pro Ile Arg Asp Val Ile Ser Leu Lys Phe Lys Ala Met Gln Ser
             205                 210                 215

 aat gga att cta ctt cac aga gaa gga caa cat gga aat cac att act      962
 Asn Gly Ile Leu Leu His Arg Glu Gly Gln His Gly Asn His Ile Thr
         220                 225                 230

 ctg gaa tta att aaa gga aag ctt gtc ttt ttt ctt aat tca ggc aat     1010
 Leu Glu Leu Ile Lys Gly Lys Leu Val Phe Phe Leu Asn Ser Gly Asn
     235                 240                 245

 gct aag ctg cct tcc act att gct cct gtg acc ctc acc ctg ggc agc     1058
 Ala Lys Leu Pro Ser Thr Ile Ala Pro Val Thr Leu Thr Leu Gly Ser
 250                 255                 260                 265

 ctg ctg gac gac cag cac tgg cat tcc gtc ctc atc gag ctc ctc gac     1106
 Leu Leu Asp Asp Gln His Trp His Ser Val Leu Ile Glu Leu Leu Asp
                 270                 275                 280

 acg cag gtc aac ttc acc gtg gac aaa cac act cat cat ttc caa gca     1154
 Thr Gln Val Asn Phe Thr Val Asp Lys His Thr His His Phe Gln Ala
             285                 290                 295

 aag gga gat tcc agt tac ttg gat ctt aat ttt gag atc agc ttt ggg     1202
 Lys Gly Asp Ser Ser Tyr Leu Asp Leu Asn Phe Glu Ile Ser Phe Gly
         300                 305                 310

 gga att ccg aca ccc gga aga tcg cgg gca ttc aga cgt aaa agc ttt     1250
 Gly Ile Pro Thr Pro Gly Arg Ser Arg Ala Phe Arg Arg Lys Ser Phe
     315                 320                 325

 cat ggg tgt tta gaa aat ctt tat tat aat gga gtg gat gtt acc gaa     1298
 His Gly Cys Leu Glu Asn Leu Tyr Tyr Asn Gly Val Asp Val Thr Glu
 330                 335                 340                 345

 tta gcc aag aaa cac aaa cca cag atc ctc atg atg gga aat gtg tcc     1346
 Leu Ala Lys Lys His Lys Pro Gln Ile Leu Met Met Gly Asn Val Ser
                 350                 355                 360

 ttc tca tgt cca cag cca cag act gtc cct gtg act ttt ctg agc tcc     1394
 Phe Ser Cys Pro Gln Pro Gln Thr Val Pro Val Thr Phe Leu Ser Ser
             365                 370                 375

 agg agt tat ctg gct ctg cca ggc aac tct ggg gag gac aaa gtg tct     1442
 Arg Ser Tyr Leu Ala Leu Pro Gly Asn Ser Gly Glu Asp Lys Val Ser
         380                 385                 390

 gtc act ttt caa ttt cga acg tgg aac aga gca gga cat ttg ctt ttc     1490
 Val Thr Phe Gln Phe Arg Thr Trp Asn Arg Ala Gly His Leu Leu Phe
     395                 400                 405

 ggc gaa ctt cga cgt ggt tca ggg agt ttc gtc ctc ttt ctt aag gat     1538
 Gly Glu Leu Arg Arg Gly Ser Gly Ser Phe Val Leu Phe Leu Lys Asp
 410                 415                 420                 425

 ggc aag ctc aaa ctg agt ctc ttc cag ccg gga cag tca cca agg aat     1586
 Gly Lys Leu Lys Leu Ser Leu Phe Gln Pro Gly Gln Ser Pro Arg Asn
                 430                 435                 440

 gtc aca gca ggt gct gga tta aac gat ggg cag tgg cac tct gtg tcc     1634
 Val Thr Ala Gly Ala Gly Leu Asn Asp Gly Gln Trp His Ser Val Ser
             445                 450                 455

 ttc tct gcc aag tgg agc cat atg aat gtg gtg gtg gac gat gac aca     1682
 Phe Ser Ala Lys Trp Ser His Met Asn Val Val Val Asp Asp Asp Thr
         460                 465                 470

 gct gtt cag ccc ctg gtg gct gtg ctc att gat tca ggt gac acc tat     1730
 Ala Val Gln Pro Leu Val Ala Val Leu Ile Asp Ser Gly Asp Thr Tyr
     475                 480                 485

 tat ttt gga ggc tgc ctg gac aac agc tct ggc tct gga tgt aaa agc     1778
 Tyr Phe Gly Gly Cys Leu Asp Asn Ser Ser Gly Ser Gly Cys Lys Ser
 490                 495                 500                 505

 ccc ctg gga ggg ttt cag ggc tgc cta agg ctc atc acc att ggt gac     1826
 Pro Leu Gly Gly Phe Gln Gly Cys Leu Arg Leu Ile Thr Ile Gly Asp
                 510                 515                 520

 aaa gcg gtg gat ccc atc tta gta cag cag ggg gcg ctg ggg agt ttc     1874
 Lys Ala Val Asp Pro Ile Leu Val Gln Gln Gly Ala Leu Gly Ser Phe
             525                 530                 535

 agg gac ctc cag ata gac tcc tgc ggc atc aca gac agg tgc ttg ccc     1922
 Arg Asp Leu Gln Ile Asp Ser Cys Gly Ile Thr Asp Arg Cys Leu Pro
         540                 545                 550

 agc tac tgt gag cat ggg ggc gag tgt tcc cag tcg tgg gac acc ttc     1970
 Ser Tyr Cys Glu His Gly Gly Glu Cys Ser Gln Ser Trp Asp Thr Phe
     555                 560                 565

 tcc tgt gac tgt cta ggc aca ggc tat acg ggc gag acc tgc cat tcc     2018
 Ser Cys Asp Cys Leu Gly Thr Gly Tyr Thr Gly Glu Thr Cys His Ser
 570                 575                 580                 585

 tct ctc tac gag cag tct tgt gaa gcc cac aag cac cga ggg aac ccg     2066
 Ser Leu Tyr Glu Gln Ser Cys Glu Ala His Lys His Arg Gly Asn Pro
                 590                 595                 600

 tct ggg ctt tac tat att gat gca gat gga agt ggc ccc ctg gga cca     2114
 Ser Gly Leu Tyr Tyr Ile Asp Ala Asp Gly Ser Gly Pro Leu Gly Pro
             605                 610                 615

 ttt ctt gtg tac tgc aat atg aca gca gac gcc gcg tgg acg gtg gtg     2162
 Phe Leu Val Tyr Cys Asn Met Thr Ala Asp Ala Ala Trp Thr Val Val
         620                 625                 630

 cag cac ggt ggc ccc gac gcg gtg acc ctc cga ggt gcc ccc agc ggg     2210
 Gln His Gly Gly Pro Asp Ala Val Thr Leu Arg Gly Ala Pro Ser Gly
     635                 640                 645

 cac ccg cgc tcg gct gtg tcc ttc gcg tac gca gcg ggc gcg ggg cag     2258
 His Pro Arg Ser Ala Val Ser Phe Ala Tyr Ala Ala Gly Ala Gly Gln
 650                 655                 660                 665

 ctg cgg tcc gcg gtg aac ctg gcg gag cgc tgc gag cag cgg ctg gct     2306
 Leu Arg Ser Ala Val Asn Leu Ala Glu Arg Cys Glu Gln Arg Leu Ala
                 670                 675                 680

 ctg cgc tgc ggg acg gcg cgg cgc ccg gac tca cga gat gga acc cca     2354
 Leu Arg Cys Gly Thr Ala Arg Arg Pro Asp Ser Arg Asp Gly Thr Pro
             685                 690                 695

 ctg agc tgg tgg gtt gga aga acc aat gaa aca cac acc tac tgg gga     2402
 Leu Ser Trp Trp Val Gly Arg Thr Asn Glu Thr His Thr Tyr Trp Gly
         700                 705                 710

 gtt tct ctg cct gat gct caa aag tgt act tgt gga tta gag ggg aac     2450
 Val Ser Leu Pro Asp Ala Gln Lys Cys Thr Cys Gly Leu Glu Gly Asn
     715                 720                 725

 tgc att gat tct cag tat tac tgc aac tgt gat gct ggc cgg aat gaa     2498
 Cys Ile Asp Ser Gln Tyr Tyr Cys Asn Cys Asp Ala Gly Arg Asn Glu
 730                 735                 740                 745

 tgg act agt gac aca ata gtc ctt tcc caa aag gag cac ctg cca gtc     2546
 Trp Thr Ser Asp Thr Ile Val Leu Ser Gln Lys Glu His Leu Pro Val
                 750                 755                 760

 act cag att gtg atg aca gac gca ggc cga cca cat tcc gaa gca gct     2594
 Thr Gln Ile Val Met Thr Asp Ala Gly Arg Pro His Ser Glu Ala Ala
             765                 770                 775

 tat aca ctg ggg cca ctg ctc tgc cgc gga gat cag tca ttc tgg aat     2642
 Tyr Thr Leu Gly Pro Leu Leu Cys Arg Gly Asp Gln Ser Phe Trp Asn
         780                 785                 790

 tca gct tcc ttc aac act gag act tca tac ctt cat ttc cct gct ttc     2690
 Ser Ala Ser Phe Asn Thr Glu Thr Ser Tyr Leu His Phe Pro Ala Phe
     795                 800                 805

 cac gga gaa ctc act gct gac gtg tgc ttc ttt ttt aag acc aca gtt     2738
 His Gly Glu Leu Thr Ala Asp Val Cys Phe Phe Phe Lys Thr Thr Val
 810                 815                 820                 825

 tcc tcc ggg gtg ttt atg gag aac ctg ggg atc aca gat ttc atc agg     2786
 Ser Ser Gly Val Phe Met Glu Asn Leu Gly Ile Thr Asp Phe Ile Arg
                 830                 835                 840

 att gag ctg cat gct ccc aca gaa gtg acc ttt tcc ttc gat gtg ggg     2834
 Ile Glu Leu His Ala Pro Thr Glu Val Thr Phe Ser Phe Asp Val Gly
             845                 850                 855

 aat gga cct tgt gag gtc acg gtg cag tca ccc act ccc ttt aat gac     2882
 Asn Gly Pro Cys Glu Val Thr Val Gln Ser Pro Thr Pro Phe Asn Asp
         860                 865                 870

 aat cag tgg cac cac gtg agg gca gag aga aat gtt aaa gga gcg tct     2930
 Asn Gln Trp His His Val Arg Ala Glu Arg Asn Val Lys Gly Ala Ser
     875                 880                 885

 ctt caa gtt gat cag ctt cct cag aag atg cag cct gcc cct gct gat     2978
 Leu Gln Val Asp Gln Leu Pro Gln Lys Met Gln Pro Ala Pro Ala Asp
 890                 895                 900                 905

 ggg cac gtt cgt tta cag ctc aac agc cag ctc ttc att ggt gga acg     3026
 Gly His Val Arg Leu Gln Leu Asn Ser Gln Leu Phe Ile Gly Gly Thr
                 910                 915                 920

 gcc acc aga cag aga ggc ttt cta gga tgc att cgg tct ctg cag ttg     3074
 Ala Thr Arg Gln Arg Gly Phe Leu Gly Cys Ile Arg Ser Leu Gln Leu
             925                 930                 935

 aac ggg gtg gcc ctg gat ctg gaa gaa aga gcc aca gtg acg cca gga     3122
 Asn Gly Val Ala Leu Asp Leu Glu Glu Arg Ala Thr Val Thr Pro Gly
         940                 945                 950

 gtg gag cca ggg tgt gca gga cac tgc agc acc tat gga cac ttg tgt     3170
 Val Glu Pro Gly Cys Ala Gly His Cys Ser Thr Tyr Gly His Leu Cys
     955                 960                 965

 cgc aat gga ggg aga tgc aga gag aaa cgc agg ggg gtc acc tgt gac     3218
 Arg Asn Gly Gly Arg Cys Arg Glu Lys Arg Arg Gly Val Thr Cys Asp
 970                 975                 980                 985

 tgt gcc ttc tca gcc tat gat ggg ccg ttc tgc tcc aat gag att tcc     3266
 Cys Ala Phe Ser Ala Tyr Asp Gly Pro Phe Cys Ser Asn Glu Ile Ser
                 990                 995                1000

 gca tat ttt gca act ggc tcc tca atg aca tac cat ttt caa gaa cat     3314
 Ala Tyr Phe Ala Thr Gly Ser Ser Met Thr Tyr His Phe Gln Glu His
            1005                1010                1015

 tac act tta agt gaa aac tcc agc tct ctc gtt tct tca tta cac aga     3362
 Tyr Thr Leu Ser Glu Asn Ser Ser Ser Leu Val Ser Ser Leu His Arg
        1020                1025                1030

 gat gta aca ttg acc aga gaa atg atc aca ctg agc ttc cga acc aca     3410
 Asp Val Thr Leu Thr Arg Glu Met Ile Thr Leu Ser Phe Arg Thr Thr
    1035                1040                1045

 cga act ccg agc tta ttg ctg tat gtg agc tct ttc tat gag gaa tac     3458
 Arg Thr Pro Ser Leu Leu Leu Tyr Val Ser Ser Phe Tyr Glu Glu Tyr
1050                1055                1060                1065

 ctt tca gtt atc ctc gcc aac aat gga agt ttg cag att agg tac aag     3506
 Leu Ser Val Ile Leu Ala Asn Asn Gly Ser Leu Gln Ile Arg Tyr Lys
                1070                1075                1080

 cta gat aga cat caa aat cct gat gca ttt acc ttt gat ttt aaa aac     3554
 Leu Asp Arg His Gln Asn Pro Asp Ala Phe Thr Phe Asp Phe Lys Asn
            1085                1090                1095

 atg gct gat ggg caa ctt cac caa gtg aag att aac aga gaa gaa gct     3602
 Met Ala Asp Gly Gln Leu His Gln Val Lys Ile Asn Arg Glu Glu Ala
        1100                1105                1110

 gtg gtc atg gta gag gtt aac cag agc aca aag aaa caa gtc atc ttg     3650
 Val Val Met Val Glu Val Asn Gln Ser Thr Lys Lys Gln Val Ile Leu
    1115                1120                1125

 tcc tca ggg aca gaa ttc aac gcc gtc aaa tct ctc ata ttg gga aag     3698
 Ser Ser Gly Thr Glu Phe Asn Ala Val Lys Ser Leu Ile Leu Gly Lys
1130                1135                1140                1145

 gtt tta gag gct gcc ggc gcg gac ccg gac aca agg cgg gcg gcg act     3746
 Val Leu Glu Ala Ala Gly Ala Asp Pro Asp Thr Arg Arg Ala Ala Thr
                1150                1155                1160

 agt ggc ttc act ggc tgc ctc tcg gcg gtg cgc ttc ggc cgc gct gct     3794
 Ser Gly Phe Thr Gly Cys Leu Ser Ala Val Arg Phe Gly Arg Ala Ala
            1165                1170                1175

 ccc ctg aag gcg gcg ctg cgc ccc agc ggc ccc tcc cgg gtc acc gtc     3842
 Pro Leu Lys Ala Ala Leu Arg Pro Ser Gly Pro Ser Arg Val Thr Val
        1180                1185                1190

 cgc ggc cac gtg gcc cct atg gcc cgc tgc gca gcg ggg gcg gcg tcc     3890
 Arg Gly His Val Ala Pro Met Ala Arg Cys Ala Ala Gly Ala Ala Ser
    1195                1200                1205

 ggc tcc ccg gcg cgg gaa ctg gct ccc cga ctc gcg ggg ggc gca ggt     3938
 Gly Ser Pro Ala Arg Glu Leu Ala Pro Arg Leu Ala Gly Gly Ala Gly
1210                1215                1220                1225

 cgt tct gga cca gcg gat gag gga gag ccc ttg gtt aat gca gac aga     3986
 Arg Ser Gly Pro Ala Asp Glu Gly Glu Pro Leu Val Asn Ala Asp Arg
                1230                1235                1240

 aga gac tct gct gtc atc gga ggt gtg ata gca gtg gtg ata ttt att     4034
 Arg Asp Ser Ala Val Ile Gly Gly Val Ile Ala Val Val Ile Phe Ile
            1245                1250                1255

 ttg ctt tgc atc act gcc ata gcc ata cgc atc tat caa cag aga aag     4082
 Leu Leu Cys Ile Thr Ala Ile Ala Ile Arg Ile Tyr Gln Gln Arg Lys
        1260                1265                1270

 tta cgc aaa gaa aat gag tca aaa gtc tca aaa aaa gaa gag tgc tag     4130
 Leu Arg Lys Glu Asn Glu Ser Lys Val Ser Lys Lys Glu Glu Cys 
    1275                1280                1285

 gacagctcta aacagtgagc tcgatgtgca aaacgcagtc catgaaaacc agaaagagcg   4190

 agtcttctga ttggcagctg tggctgtctc tatcatcgtg actgtggact tccctgctgt   4250

 tgccatcagg gtgcacacaa gcaggtgcag tgctgtcacc tggctgaaga cctgcagcct   4310

 cggagcctct gggaggtccc tttctccctc ggtgaaacac agtcctccac atcaatttcc   4370

 aaacaatgaa ttaggtatgg ccattcatca ctgttcagta gtttccccgt ccaaaggctc   4430

 tcttccaaaa ctgcagtttg atctgtgtta ataattgtgg ggttttagat gagaaaatgg   4490

 ctataaagct gtggccctac tttatttttt aaaaatgaca gaacttttgt tcagatgtaa   4550

 aagacaaaat tgcactttaa tgttttttgt tacttgaaaa catatctggg atcccttttt   4610

 ttggtcctct gctgatattt ataaaacaag aaatgcttct tggactacct tcactggcat   4670

 ttccatagtc ctggaatcca gagccaagtg gcctatctaa aattcacagc ccttttattc   4730

 tcctgtgtga tggttaatac aacacagttg aagcctggaa acactaccat tatttttggt   4790

 gtattgcttt ttctaattga ctgtttttaa tgattttgat acattttaat gttgaaatta   4850

 atattgaatg ttagctatga aattttagta ttgaatttta taatggaaca gaacattggt   4910

 aggtaacaag atgcaagagg atgtcaatac aagattgtct gcctgttttt ctttgtaatt   4970

 tgtaattaca gtttttgtaa cttgtgatta tgtttttaac taaatttacc accagataca   5030

 aacaatactt cttacacaga gttatccttt atttatatca ttaagacgtg aatgaaacat   5090

 catcctaact tacttcccca agatattgag aggtcatatc tgtttttctt tatcattcat   5150

 ttctttttct aaaagttgtt actgatatgc ttttgatttc ctatgactct attatgttgt   5210

 acagaacatc ttttcaattt attaaaaaaa tagcttaact gaaaaaaaaa aaa          5263




      <210> 447
      <211> 2557
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(1801)

      <400> 447
 tttg atg gtt tcc ctt aga aaa gtc aaa gtg ctg ttg gtc cta aac atg      49
      Met Val Ser Leu Arg Lys Val Lys Val Leu Leu Val Leu Asn Met
        1               5                  10                  15

 ata cgc gta gcc ggc ttc gtg ctc ttc ctg ggc aag tgc agg ccc atc       97
 Ile Arg Val Ala Gly Phe Val Leu Phe Leu Gly Lys Cys Arg Pro Ile
                  20                  25                  30

 gcg gtg cgc agc gga gac gcc ttc cac gag atc cgg ccg cgc gcc gag      145
 Ala Val Arg Ser Gly Asp Ala Phe His Glu Ile Arg Pro Arg Ala Glu
              35                  40                  45

 gtg gcc aac ctc agc gcg cac agc gcc agc ccc atc cag gat gcg gtc      193
 Val Ala Asn Leu Ser Ala His Ser Ala Ser Pro Ile Gln Asp Ala Val
          50                  55                  60

 ctg aag cgc ctg tcg ctg ctg gag gac atc gtg tac cgg cag ctg aat      241
 Leu Lys Arg Leu Ser Leu Leu Glu Asp Ile Val Tyr Arg Gln Leu Asn
      65                  70                  75

 ggc tta tcc aaa tcc ctt ggg ctc att gaa ggt tat ggt ggg cgg ggt      289
 Gly Leu Ser Lys Ser Leu Gly Leu Ile Glu Gly Tyr Gly Gly Arg Gly
  80                  85                  90                  95

 aaa ggg ggc ctt ccg gct act ctt tcc ccg gct gaa gaa gaa aag gct      337
 Lys Gly Gly Leu Pro Ala Thr Leu Ser Pro Ala Glu Glu Glu Lys Ala
                 100                 105                 110

 aag gga ccc cat gag aag tat ggc tac aat tca tac ctc agt gaa aaa      385
 Lys Gly Pro His Glu Lys Tyr Gly Tyr Asn Ser Tyr Leu Ser Glu Lys
             115                 120                 125

 att tca ctg gac cgt tcc att ccg gat tat cgt ccc acc aag tgt aag      433
 Ile Ser Leu Asp Arg Ser Ile Pro Asp Tyr Arg Pro Thr Lys Cys Lys
         130                 135                 140

 gag ctc aag tac tcc aag gac ctg ccc cag ata tcc atc ata ttc atc      481
 Glu Leu Lys Tyr Ser Lys Asp Leu Pro Gln Ile Ser Ile Ile Phe Ile
     145                 150                 155

 ttc gtg aac gag gcc ctg tcg gtg atc ctg cgg tcc gtg cac agt gcc      529
 Phe Val Asn Glu Ala Leu Ser Val Ile Leu Arg Ser Val His Ser Ala
 160                 165                 170                 175

 gtc aat cac acg ccc aca cac ctg ctg aag gaa atc att ctg gtg gat      577
 Val Asn His Thr Pro Thr His Leu Leu Lys Glu Ile Ile Leu Val Asp
                 180                 185                 190

 gac aac agc gac gaa gag gag ctg aag gtc ccc cta gag gag tat gtc      625
 Asp Asn Ser Asp Glu Glu Glu Leu Lys Val Pro Leu Glu Glu Tyr Val
             195                 200                 205

 cac aaa cgc tac ccc ggg ctg gtg aag gtg gta aga aat cag aag agg      673
 His Lys Arg Tyr Pro Gly Leu Val Lys Val Val Arg Asn Gln Lys Arg
         210                 215                 220

 gaa ggc ctg atc cgc gct cgc att gag ggc tgg aag gtg gct acc ggg      721
 Glu Gly Leu Ile Arg Ala Arg Ile Glu Gly Trp Lys Val Ala Thr Gly
     225                 230                 235

 cag gtc act ggc ttc ttt gat gcc cac gtg gaa ttc acc gct ggc tgg      769
 Gln Val Thr Gly Phe Phe Asp Ala His Val Glu Phe Thr Ala Gly Trp
 240                 245                 250                 255

 gct gag ccg gtt cta tcc cgc atc cag gaa aac cgg aag cgt gtg atc      817
 Ala Glu Pro Val Leu Ser Arg Ile Gln Glu Asn Arg Lys Arg Val Ile
                 260                 265                 270

 ctc ccc tcc att gac aac atc aaa cag gac aac ttt gag gtg cag cgg      865
 Leu Pro Ser Ile Asp Asn Ile Lys Gln Asp Asn Phe Glu Val Gln Arg
             275                 280                 285

 tac gag aac tcg gcc cac ggg tac agc tgg gag ctg tgg tgc atg tac      913
 Tyr Glu Asn Ser Ala His Gly Tyr Ser Trp Glu Leu Trp Cys Met Tyr
         290                 295                 300

 atc agc ccc cca aaa gac tgg tgg gac gcc gga gac cct tct ctc ccc      961
 Ile Ser Pro Pro Lys Asp Trp Trp Asp Ala Gly Asp Pro Ser Leu Pro
     305                 310                 315

 atc agg acc cca gcc atg ata ggc tgc tcg ttc gtg gtc aac agg aag     1009
 Ile Arg Thr Pro Ala Met Ile Gly Cys Ser Phe Val Val Asn Arg Lys
 320                 325                 330                 335

 ttc ttc ggt gaa att ggt ctt ctg gat cct ggc atg gat gta tac gga     1057
 Phe Phe Gly Glu Ile Gly Leu Leu Asp Pro Gly Met Asp Val Tyr Gly
                 340                 345                 350

 gga gaa aat att gaa ctg gga atc aag gta tgg ctc tgt ggg ggc agc     1105
 Gly Glu Asn Ile Glu Leu Gly Ile Lys Val Trp Leu Cys Gly Gly Ser
             355                 360                 365

 atg gag gtc ctt cct tgc tca cgg gtg gcc cac att gag cgg aag aag     1153
 Met Glu Val Leu Pro Cys Ser Arg Val Ala His Ile Glu Arg Lys Lys
         370                 375                 380

 aag cca tat aat agc aac att ggc ttc tac acc aag agg aat gct ctt     1201
 Lys Pro Tyr Asn Ser Asn Ile Gly Phe Tyr Thr Lys Arg Asn Ala Leu
     385                 390                 395

 cgc gtt gct gag gtc tgg atg gac gat tac aag tct cat gtg tac ata     1249
 Arg Val Ala Glu Val Trp Met Asp Asp Tyr Lys Ser His Val Tyr Ile
 400                 405                 410                 415

 gcg tgg aac ctg ccg ctg gag aat ccg gga att gac atc ggt gat gtc     1297
 Ala Trp Asn Leu Pro Leu Glu Asn Pro Gly Ile Asp Ile Gly Asp Val
                 420                 425                 430

 tcc gaa aga aga gca tta agg aaa agt tta aag tgt aag aat ttc cag     1345
 Ser Glu Arg Arg Ala Leu Arg Lys Ser Leu Lys Cys Lys Asn Phe Gln
             435                 440                 445

 tgg tac ctg gac cat gtt tac cca gaa atg aga aga tac aat aat acc     1393
 Trp Tyr Leu Asp His Val Tyr Pro Glu Met Arg Arg Tyr Asn Asn Thr
         450                 455                 460

 gtt gct tac ggg gag ctt cgc aac aac aag gca aaa gac gtc tgc ttg     1441
 Val Ala Tyr Gly Glu Leu Arg Asn Asn Lys Ala Lys Asp Val Cys Leu
     465                 470                 475

 gac cag ggg ccg ctg gag aac cac aca gca ata ttg tat ccg tgc cat     1489
 Asp Gln Gly Pro Leu Glu Asn His Thr Ala Ile Leu Tyr Pro Cys His
 480                 485                 490                 495

 ggc tgg gga cca cag ctt gcc cgc tac acc aag gaa ggc ttc ctg cac     1537
 Gly Trp Gly Pro Gln Leu Ala Arg Tyr Thr Lys Glu Gly Phe Leu His
                 500                 505                 510

 ttg ggt gcc ctg ggg acc acc aca ctc ctc cct gac acc cgc tgc ctg     1585
 Leu Gly Ala Leu Gly Thr Thr Thr Leu Leu Pro Asp Thr Arg Cys Leu
             515                 520                 525

 gtg gac aac tcc aag agt cgg ctg ccc cag ctc ctg gac tgc gac aag     1633
 Val Asp Asn Ser Lys Ser Arg Leu Pro Gln Leu Leu Asp Cys Asp Lys
         530                 535                 540

 gtc aag agc agc ctg tac aag cgc tgg aac ttc atc cag aat gga gcc     1681
 Val Lys Ser Ser Leu Tyr Lys Arg Trp Asn Phe Ile Gln Asn Gly Ala
     545                 550                 555

 atc atg aac aag ggc acg gga cgc tgc ctg gag gtg gag aac cgg ggc     1729
 Ile Met Asn Lys Gly Thr Gly Arg Cys Leu Glu Val Glu Asn Arg Gly
 560                 565                 570                 575

 ctg gct ggc atc gac ctc atc ctc cgc agc tgc aca ggt cag agg tgg     1777
 Leu Ala Gly Ile Asp Leu Ile Leu Arg Ser Cys Thr Gly Gln Arg Trp
                 580                 585                 590

 acc att aag aac tcc atc aag tag agggagggag ctggggcact ggagcctggc    1831
 Thr Ile Lys Asn Ser Ile Lys 
             595

 ccccaggaca tggctgctcc ccccaacatc tggaccagct gccctggcgg agagacagca   1891

 aggggccggc aggtgctcga tgggcccccc agggcttctc cagggcagca cagggacccc   1951

 ggatgaagac tctgtccccc ctcaggcatt cagctgccca caagtttcct gcaccctgga   2011

 aaagcccccc acccttcctc tgggaaactg acagctgtct tccacagcct ctgatgtgga   2071

 cctggtactg aggagcaaga ctgtccagtt ctcctccaca tctcccatcc cagaatcagg   2131

 atctgggact ggcagggtcc cctcctgtgt ctcatctctt gcagcaacag ctgcttgaac   2191

 tccaagccat caacacggtg ggaggcagcg ggggcttcag ccatgtccta gctccccgcc   2251

 ctaaaaggag gcagtgagga ccaggcacta tttcctccga ggttacttct acccagatga   2311

 cacctgcctg ttcacgcccc aaggcagcta ctgcccctaa cccttcccac cagggtagct   2371

 ttgggcactg cagctctgga cttttctggc ccctcctgag atgacctgat ggagctgatg   2431

 ctttctctcc taatccctgg gcactaggct cttatcagag tgcttgggcc agctctcctg   2491

 cctgtgtcta gaaggaagcc agagacagaa ataggctaag cctgcagtag gatctcagac   2551

 acaaag                                                              2557




      <210> 448
      <211> 1356
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (262)..(993)

      <400> 448
 cccagcccac gtgctaacca agcggctcgc ttcccgagcc cgggatggag caccgcgcct     60

 agggaggccg cgccgcccga gacgtgcgca cggttcgtgg cggagagatg ctgatcgcgc    120

 tgaactgacc ggtgcggccc gggggtgagt ggcgagtctc cctctgagtc ctccccagca    180

 gcgcggccgg cgccggctct ttgggcgaac cctccagttc ctagactttg agaggcgtct    240

 ctcccccgcc cgaccgccca g  atg cag ttt cgc ctt ttc tcc ttt gcc ctc     291
                          Met Gln Phe Arg Leu Phe Ser Phe Ala Leu
                            1               5                  10

 atc att ctg aac tgc atg gat tac agc cac tgc caa ggc aac cga tgg      339
 Ile Ile Leu Asn Cys Met Asp Tyr Ser His Cys Gln Gly Asn Arg Trp
                  15                  20                  25

 aga cgc agt aag cga gct agt tat gta tca aat ccc att tgc aag ggt      387
 Arg Arg Ser Lys Arg Ala Ser Tyr Val Ser Asn Pro Ile Cys Lys Gly
              30                  35                  40

 tgt ttg tct tgt tca aag gac aat ggg tgt agc cga tgt caa cag aag      435
 Cys Leu Ser Cys Ser Lys Asp Asn Gly Cys Ser Arg Cys Gln Gln Lys
          45                  50                  55

 ttg ttc ttc ttc ctt cga aga gaa ggg atg cgc cag tat gga gag tgc      483
 Leu Phe Phe Phe Leu Arg Arg Glu Gly Met Arg Gln Tyr Gly Glu Cys
      60                  65                  70

 ctg cat tcc tgc cca tcc ggg tac tat gga cac cga gcc cca gat atg      531
 Leu His Ser Cys Pro Ser Gly Tyr Tyr Gly His Arg Ala Pro Asp Met
  75                  80                  85                  90

 aac aga tgt gca aga tgc aga ata gaa aac tgt gat tct tgc ttt agc      579
 Asn Arg Cys Ala Arg Cys Arg Ile Glu Asn Cys Asp Ser Cys Phe Ser
                  95                 100                 105

 aaa gac ttt tgt acc aag tgc aaa gta ggc ttt tat ttg cat aga ggc      627
 Lys Asp Phe Cys Thr Lys Cys Lys Val Gly Phe Tyr Leu His Arg Gly
             110                 115                 120

 cgt tgc ttt gat gaa tgt cca gat ggt ttt gca cca tta gaa gaa acc      675
 Arg Cys Phe Asp Glu Cys Pro Asp Gly Phe Ala Pro Leu Glu Glu Thr
         125                 130                 135

 atg gaa tgt gtg gaa gga tgt gaa gtt ggt cat tgg agc gaa tgg gga      723
 Met Glu Cys Val Glu Gly Cys Glu Val Gly His Trp Ser Glu Trp Gly
     140                 145                 150

 act tgt agc aga aat aat cgc aca tgt gga ttt aaa tgg ggt ctg gaa      771
 Thr Cys Ser Arg Asn Asn Arg Thr Cys Gly Phe Lys Trp Gly Leu Glu
 155                 160                 165                 170

 acc aga aca cgg caa att gtt aaa aag cca gtg aaa gac aca ata ccg      819
 Thr Arg Thr Arg Gln Ile Val Lys Lys Pro Val Lys Asp Thr Ile Pro
                 175                 180                 185

 tgt cca acc att gct gaa tcc agg aga tgc aag atg aca atg agg cat      867
 Cys Pro Thr Ile Ala Glu Ser Arg Arg Cys Lys Met Thr Met Arg His
             190                 195                 200

 tgt cca gga ggg aag aga aca cca aag gcg aag gag aag agg aac aag      915
 Cys Pro Gly Gly Lys Arg Thr Pro Lys Ala Lys Glu Lys Arg Asn Lys
         205                 210                 215

 aaa aag aaa agg aag ctg ata gaa agg gcc cag gag caa cac agc gtc      963
 Lys Lys Lys Arg Lys Leu Ile Glu Arg Ala Gln Glu Gln His Ser Val
     220                 225                 230

 ttc cta gct aca gac aga gct aac caa taa a acaagagatc cggtagattt     1014
 Phe Leu Ala Thr Asp Arg Ala Asn Gln 
 235                 240

 ttaggggttt ttgtttttgc aaatgtgcac aaagctactc tccactcctg cacactgggg   1074

 tgcagccttt gtgctgctct gcccagtatc tgttcccagt aacatggtga aaggaagcac   1134

 caccaggcat gcccctgtgt tatttatgct ttgatttgaa tctggagact gtgaaggcag   1194

 gagtaagtgc acagccccgt gacttggctc agtgtgtgct gagagaatcc gtcccccgca   1254

 ccatggacat gctagaggtg tgaggctgca gaacaccgct ggaggacgga cttgtgccta   1314

 tttatgtgaa agaagatgct tggcaggcaa tccgcgtgta tt                      1356




      <210> 449
      <211> 2382
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1851)

      <400> 449
  atg tcc acc atc cag tcg gag act gac tgc tac gac atc atc gag gtc      48
  Met Ser Thr Ile Gln Ser Glu Thr Asp Cys Tyr Asp Ile Ile Glu Val
    1               5                  10                  15

 ttg ggc aag ggg acc ttc ggg gag gta gcc aag ggc tgg cgg cgg agc       96
 Leu Gly Lys Gly Thr Phe Gly Glu Val Ala Lys Gly Trp Arg Arg Ser
              20                  25                  30

 acg ggc gag atg gtg gcc atc aag atc ctc aag aat gac gcc tac cgc      144
 Thr Gly Glu Met Val Ala Ile Lys Ile Leu Lys Asn Asp Ala Tyr Arg
          35                  40                  45

 aac cgc atc atc aag aac gag ctg aag ctg ctg cac tgc atg cga ggc      192
 Asn Arg Ile Ile Lys Asn Glu Leu Lys Leu Leu His Cys Met Arg Gly
      50                  55                  60

 cta gac cct gaa gag gcc cac gtc atc cgc ttc ctt gag ttc ttc cat      240
 Leu Asp Pro Glu Glu Ala His Val Ile Arg Phe Leu Glu Phe Phe His
  65                  70                  75                  80

 gac gcc ctc aag ttc tac ctg gtc ttt gag ctg ctg gag caa aac ctt      288
 Asp Ala Leu Lys Phe Tyr Leu Val Phe Glu Leu Leu Glu Gln Asn Leu
                  85                  90                  95

 ttc gag ttc cag aag gag aac aac ttc gcg ccc ctc ccc gcc cgc cac      336
 Phe Glu Phe Gln Lys Glu Asn Asn Phe Ala Pro Leu Pro Ala Arg His
             100                 105                 110

 atc cgt aca gtc acc ctg cag gtg ctc aca gcc ctg gcc cgg ctc aag      384
 Ile Arg Thr Val Thr Leu Gln Val Leu Thr Ala Leu Ala Arg Leu Lys
         115                 120                 125

 gag ctg gct atc atc cac gct gat ctc aag cct gag aac atc atg ctg      432
 Glu Leu Ala Ile Ile His Ala Asp Leu Lys Pro Glu Asn Ile Met Leu
     130                 135                 140

 gtg gac cag acc cgc tgc ccc ttc agg gtc aag gtg att gac ttc gga      480
 Val Asp Gln Thr Arg Cys Pro Phe Arg Val Lys Val Ile Asp Phe Gly
 145                 150                 155                 160

 tcc gcc agc att ttc agc gag gtg cgc tac gtg aag gag cca tac atc      528
 Ser Ala Ser Ile Phe Ser Glu Val Arg Tyr Val Lys Glu Pro Tyr Ile
                 165                 170                 175

 cag tcg cgc ttc tac cgg gcc cct gag atc ctg ctg ggg ctg ccc ttc      576
 Gln Ser Arg Phe Tyr Arg Ala Pro Glu Ile Leu Leu Gly Leu Pro Phe
             180                 185                 190

 tgc gag aag gtg gac gtg tgg tcc ctg ggc tgc gtc atg gct gag ctg      624
 Cys Glu Lys Val Asp Val Trp Ser Leu Gly Cys Val Met Ala Glu Leu
         195                 200                 205

 cac ctg ggc tgg cct ctc tac ccc ggc aac aac gag tac gac cag gtg      672
 His Leu Gly Trp Pro Leu Tyr Pro Gly Asn Asn Glu Tyr Asp Gln Val
     210                 215                 220

 cgc tac atc tgc gaa acc cag ggc ctg ccc aag cca cac ctg ttg cac      720
 Arg Tyr Ile Cys Glu Thr Gln Gly Leu Pro Lys Pro His Leu Leu His
 225                 230                 235                 240

 gcc gcc tgc aag gcc cac cac ttc ttc aag cgc aac ccc cac cct gac      768
 Ala Ala Cys Lys Ala His His Phe Phe Lys Arg Asn Pro His Pro Asp
                 245                 250                 255

 gct gcc aac ccc tgg cag ctc aag tcc tcg gct gac tac ctg gcc gag      816
 Ala Ala Asn Pro Trp Gln Leu Lys Ser Ser Ala Asp Tyr Leu Ala Glu
             260                 265                 270

 acg aag gtg cgc cca ttg gag cgc cgc aag tat atg ctc aag tcg ttg      864
 Thr Lys Val Arg Pro Leu Glu Arg Arg Lys Tyr Met Leu Lys Ser Leu
         275                 280                 285

 gac cag att gag aca gtg aat ggt ggc agt gtg gcc agt cgg cta acc      912
 Asp Gln Ile Glu Thr Val Asn Gly Gly Ser Val Ala Ser Arg Leu Thr
     290                 295                 300

 ttc cct gac cgg gag gcg ctg gcg gag cac gcc gac ctc aag agc atg      960
 Phe Pro Asp Arg Glu Ala Leu Ala Glu His Ala Asp Leu Lys Ser Met
 305                 310                 315                 320

 gtg gag ctg atc aag cgc atg ctg acc tgg gag tca cac gaa cgc atc     1008
 Val Glu Leu Ile Lys Arg Met Leu Thr Trp Glu Ser His Glu Arg Ile
                 325                 330                 335

 agc ccc agt gct gcc ctg cgc cac ccc ttc gtg tcc atg cag cag ctg     1056
 Ser Pro Ser Ala Ala Leu Arg His Pro Phe Val Ser Met Gln Gln Leu
             340                 345                 350

 cgc agt gcc cac gag acc acc cac tac tac cag ctc tcg ctg cgc agc     1104
 Arg Ser Ala His Glu Thr Thr His Tyr Tyr Gln Leu Ser Leu Arg Ser
         355                 360                 365

 tac cgc ctc tcg ctg caa gtg gag ggg aag ccc ccc acg ccc gtc gtg     1152
 Tyr Arg Leu Ser Leu Gln Val Glu Gly Lys Pro Pro Thr Pro Val Val
     370                 375                 380

 gcc gca gaa gat ggg acc ccc tac tac tgt ctg gct gag gag aag gag     1200
 Ala Ala Glu Asp Gly Thr Pro Tyr Tyr Cys Leu Ala Glu Glu Lys Glu
 385                 390                 395                 400

 gct gcg ggt atg ggc agt gtg gcc ggc agc agc ccc ttc ttc cga gag     1248
 Ala Ala Gly Met Gly Ser Val Ala Gly Ser Ser Pro Phe Phe Arg Glu
                 405                 410                 415

 gag aag gca cca ggt atg caa aga gcc atc gac cag ctg gat gac ctg     1296
 Glu Lys Ala Pro Gly Met Gln Arg Ala Ile Asp Gln Leu Asp Asp Leu
             420                 425                 430

 agt ctg cag gag gct ggg cat ggg ctg tgg ggt gag acc tgc acc aat     1344
 Ser Leu Gln Glu Ala Gly His Gly Leu Trp Gly Glu Thr Cys Thr Asn
         435                 440                 445

 gcg gtc tcc gac atg atg gtc ccc ctc aag gca gcc atc act ggc cac     1392
 Ala Val Ser Asp Met Met Val Pro Leu Lys Ala Ala Ile Thr Gly His
     450                 455                 460

 cat gtg ccc gac tcg ggc cct gag ccc atc ctg gcc ttc tac agc agc     1440
 His Val Pro Asp Ser Gly Pro Glu Pro Ile Leu Ala Phe Tyr Ser Ser
 465                 470                 475                 480

 cgc ctg gca ggc cgc cac aag gcc cgc aag cca cct gcg ggt tcc aag     1488
 Arg Leu Ala Gly Arg His Lys Ala Arg Lys Pro Pro Ala Gly Ser Lys
                 485                 490                 495

 tcc gac tcc aac ttc agc aac ctc att cgg ctg agc cag gtc tcg cct     1536
 Ser Asp Ser Asn Phe Ser Asn Leu Ile Arg Leu Ser Gln Val Ser Pro
             500                 505                 510

 gag gat gac agg ccc tgc cgg ggc agc agc tgg gag gaa gga gag cat     1584
 Glu Asp Asp Arg Pro Cys Arg Gly Ser Ser Trp Glu Glu Gly Glu His
         515                 520                 525

 ctc ggg gcc tct gct gag cca ctg gcc atc ctg cag cga gat gag gat     1632
 Leu Gly Ala Ser Ala Glu Pro Leu Ala Ile Leu Gln Arg Asp Glu Asp
     530                 535                 540

 ggg ccc aac att gac aac atg acc atg gaa gct gag agg cca gac cct     1680
 Gly Pro Asn Ile Asp Asn Met Thr Met Glu Ala Glu Arg Pro Asp Pro
 545                 550                 555                 560

 gag ctc ttc gac ccc agc agc tgt cct gga gaa tgg ctg agt gag cca     1728
 Glu Leu Phe Asp Pro Ser Ser Cys Pro Gly Glu Trp Leu Ser Glu Pro
                 565                 570                 575

 gac tgc acc ctg gag agc gtc agg ggc cca cgg gct cag ggg ctc cca     1776
 Asp Cys Thr Leu Glu Ser Val Arg Gly Pro Arg Ala Gln Gly Leu Pro
             580                 585                 590

 ccc cgc cgc tcc cac cag cat ggt cca ccc cgg ggg gcc acc agc ttc     1824
 Pro Arg Arg Ser His Gln His Gly Pro Pro Arg Gly Ala Thr Ser Phe
         595                 600                 605

 ctc cag cat gtc acc ggg cac cac tga tggtg attccacccc tgcccatcac     1876
 Leu Gln His Val Thr Gly His His 
     610                 615

 tgggggctgc gctagctggg ctggcattcc ctcccaacct gaactgctcc tcagagccat   1936

 ctcctgaacc cacaaattat tcttacagaa agatagttat ccagaaattc tcattccccg   1996

 gtctgcggtg cggtgcgtgc ctgcacacct ctcctaaaca cagcagggct ttggagtctg   2056

 gcccatgctc cttggccaga aggacagcag gaaagggggc tgcacccccg tggcctgcgc   2116

 tcgcccttgg cctgctgctc tgtctatttc aatatagaac tgttcagcag tcctgcttca   2176

 gcctgctctc actggctggg gcttggactg gcctggggga tgggggtccg ctgcaccagt   2236

 gactgtctgg atgtgggcag tgaccttgtt aggggacctg ggtgtggccc taggggaagc   2296

 cggttgttgt acctgtctaa tactttgttg gttgggtccc cccacatggg gtcctttttc   2356

 cttcggcgcg gcaacaaaaa aaaaaa                                        2382




      <210> 450
      <211> 423
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (151)..(333)

      <400> 450
 ctggtagtga gctcagaccc tgcagtggga tggggtgctc tctgctaggt gctgaccccg     60

 cacaggtatg gggtgctgtc tgccaggtgc tgaccccgca gagatccgtt cttccccctc    120

 tccttcctgg tcaacagctg gctcccaggg     atg ctg gat gac ctc ttt cag     171
                                      Met Leu Asp Asp Leu Phe Gln
                                        1               5

 tcc atg ttc ctg tgc gcc ctg ctg ctc ttc tgg ctg tgc gtg tac cac      219
 Ser Met Phe Leu Cys Ala Leu Leu Leu Phe Trp Leu Cys Val Tyr His
          10                  15                  20

 ggg att cgt gtc cag gga gaa aga aag tgt tta act ttc tat ttg cct      267
 Gly Ile Arg Val Gln Gly Glu Arg Lys Cys Leu Thr Phe Tyr Leu Pro
      25                  30                  35

 aaa ttc ttc att gtt gga cta ttg tgg ttg gct tct gtt acg cta gga      315
 Lys Phe Phe Ile Val Gly Leu Leu Trp Leu Ala Ser Val Thr Leu Gly
  40                  45                  50                  55

 ata tgg caa acg gaa tga aggtct tcttcatggt ggtggcagcg gtgtacattc      369
 Ile Trp Gln Thr Glu 
                  60

 tgtacctctt gttcttgata gtgcgggcgt gttccgagct acgtcacatg cctt          423




      <210> 451
      <211> 4351
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(2452)

      <400> 451
 ggaccccggt gtctggcttc ccccgagccg ggaccccgcg  atg gcc aag cgc agc      55
                                              Met Ala Lys Arg Ser
                                                1               5

 tcg ctg tac atc cgc atc gtg gag ggg aag aac ctt ccc gcc aag gac      103
 Ser Leu Tyr Ile Arg Ile Val Glu Gly Lys Asn Leu Pro Ala Lys Asp
                  10                  15                  20

 atc act ggc agc agc gac ccc tac tgc atc gtg aag gtg gac aat gag      151
 Ile Thr Gly Ser Ser Asp Pro Tyr Cys Ile Val Lys Val Asp Asn Glu
              25                  30                  35

 ccc atc atc agg aca gcc aca gtg tgg aag acc ctg tgc ccc ttc tgg      199
 Pro Ile Ile Arg Thr Ala Thr Val Trp Lys Thr Leu Cys Pro Phe Trp
          40                  45                  50

 ggt gag gag tac caa gtg cac ctg ccg ccc acc ttc cac gct gtg gct      247
 Gly Glu Glu Tyr Gln Val His Leu Pro Pro Thr Phe His Ala Val Ala
      55                  60                  65

 ttc tat gtc atg gat gag gat gcc ctc agc cgg gac gac gtt atc gga      295
 Phe Tyr Val Met Asp Glu Asp Ala Leu Ser Arg Asp Asp Val Ile Gly
  70                  75                  80                  85

 aag gtc tgc ctt aca agg gac acc ata gcc tct cac cct aag ggt ttc      343
 Lys Val Cys Leu Thr Arg Asp Thr Ile Ala Ser His Pro Lys Gly Phe
                  90                  95                 100

 agc ggg tgg gcc cac ctg acg gag gtc gac ccc gac gag gag gtg cag      391
 Ser Gly Trp Ala His Leu Thr Glu Val Asp Pro Asp Glu Glu Val Gln
             105                 110                 115

 ggc gag atc cac ctg cgg ctg gaa gtg tgg cca ggg gcc cgg gcc tgc      439
 Gly Glu Ile His Leu Arg Leu Glu Val Trp Pro Gly Ala Arg Ala Cys
         120                 125                 130

 cgg cta cgc tgc tct gtg ctg gag gcc agg gat ctg gcc cca aag gac      487
 Arg Leu Arg Cys Ser Val Leu Glu Ala Arg Asp Leu Ala Pro Lys Asp
     135                 140                 145

 cgc aat ggc aca tct gac ccc ttc gtc cga gtg cgc tac aag ggc cgg      535
 Arg Asn Gly Thr Ser Asp Pro Phe Val Arg Val Arg Tyr Lys Gly Arg
 150                 155                 160                 165

 aca cgg gag acc tcg atc gtg aag aag tca tgc tac cca cgc tgg aat      583
 Thr Arg Glu Thr Ser Ile Val Lys Lys Ser Cys Tyr Pro Arg Trp Asn
                 170                 175                 180

 gag acg ttt gaa ttt gag ctg cag gag ggg gcc atg gag gcg ctg tgc      631
 Glu Thr Phe Glu Phe Glu Leu Gln Glu Gly Ala Met Glu Ala Leu Cys
             185                 190                 195

 gtg gag gcc tgg gac tgg gac ctt gtc agc cga aac gac ttc ctg ggc      679
 Val Glu Ala Trp Asp Trp Asp Leu Val Ser Arg Asn Asp Phe Leu Gly
         200                 205                 210

 aaa gtg gtg att gat gtc cag aga ctg cgg gtg gtg cag cag gag gag      727
 Lys Val Val Ile Asp Val Gln Arg Leu Arg Val Val Gln Gln Glu Glu
     215                 220                 225

 ggc tgg ttc cgg ctg cag ccc gac cag tcc aag agc cgg cgg cat gac      775
 Gly Trp Phe Arg Leu Gln Pro Asp Gln Ser Lys Ser Arg Arg His Asp
 230                 235                 240                 245

 gag ggc aac ctg ggc tcc ttg cag ctg gag gtg cgg ctg cgg gac gag      823
 Glu Gly Asn Leu Gly Ser Leu Gln Leu Glu Val Arg Leu Arg Asp Glu
                 250                 255                 260

 acg gtg ctg ccc tcc agc tac tac cag cca ctg gtg cac ctg ctg tgc      871
 Thr Val Leu Pro Ser Ser Tyr Tyr Gln Pro Leu Val His Leu Leu Cys
             265                 270                 275

 cac gag gtc aag ctg ggc atg cag ggc cca ggg cag ctg atc cca ctc      919
 His Glu Val Lys Leu Gly Met Gln Gly Pro Gly Gln Leu Ile Pro Leu
         280                 285                 290

 atc gag gag aca acc agc acc gag tgt cgc cag gac gtg gcc acg aac      967
 Ile Glu Glu Thr Thr Ser Thr Glu Cys Arg Gln Asp Val Ala Thr Asn
     295                 300                 305

 ctg ctc aag ctc ttc ctg ggg cag ggg ctg gcc aag gac ttc ctg gac     1015
 Leu Leu Lys Leu Phe Leu Gly Gln Gly Leu Ala Lys Asp Phe Leu Asp
 310                 315                 320                 325

 ctg ctc ttc cag ctg gag ctg agt cgc acc agt gag acc aac acc ctg     1063
 Leu Leu Phe Gln Leu Glu Leu Ser Arg Thr Ser Glu Thr Asn Thr Leu
                 330                 335                 340

 ttc cgg agc aac tct ctg gcc tca aag tcc atg gag tct ttt ctg aag     1111
 Phe Arg Ser Asn Ser Leu Ala Ser Lys Ser Met Glu Ser Phe Leu Lys
             345                 350                 355

 gtg gcc ggg atg cag tac ctg cac ggc gtc ctg ggc ccc atc atc aac     1159
 Val Ala Gly Met Gln Tyr Leu His Gly Val Leu Gly Pro Ile Ile Asn
         360                 365                 370

 aag gtg ttt gag gag aag aag tac gtg gag ctg gac ccc agc aaa gtg     1207
 Lys Val Phe Glu Glu Lys Lys Tyr Val Glu Leu Asp Pro Ser Lys Val
     375                 380                 385

 gaa gtt aag gat gta ggg tgc tcc ggg ctg cac cgc ccg cag acc gag     1255
 Glu Val Lys Asp Val Gly Cys Ser Gly Leu His Arg Pro Gln Thr Glu
 390                 395                 400                 405

 gcc gag gtg ctg gag cag agc gcg cag acg ctg cgc gcc cac ctg ggg     1303
 Ala Glu Val Leu Glu Gln Ser Ala Gln Thr Leu Arg Ala His Leu Gly
                 410                 415                 420

 gcc ctg ctg agc gcg ctc agc cgc tcg gtt cgc gcg tgc ccc gcc gtg     1351
 Ala Leu Leu Ser Ala Leu Ser Arg Ser Val Arg Ala Cys Pro Ala Val
             425                 430                 435

 gtg cgc gcc acc ttc cgc cag ctc ttc cgg cgc gtg cgc gag cgc ttc     1399
 Val Arg Ala Thr Phe Arg Gln Leu Phe Arg Arg Val Arg Glu Arg Phe
         440                 445                 450

 ccc ggc gcc cag cac gag aat gta ccg ttc atc gcc gtc acc agc ttc     1447
 Pro Gly Ala Gln His Glu Asn Val Pro Phe Ile Ala Val Thr Ser Phe
     455                 460                 465

 ctg tgc ctg cgc ttc ttc tct ccc gcc atc atg tcg ccc aag ctc ttc     1495
 Leu Cys Leu Arg Phe Phe Ser Pro Ala Ile Met Ser Pro Lys Leu Phe
 470                 475                 480                 485

 cac ctg cgg gag cgc cac gcg gac gcc cgc acc agc cgc acc ctg ctc     1543
 His Leu Arg Glu Arg His Ala Asp Ala Arg Thr Ser Arg Thr Leu Leu
                 490                 495                 500

 ctg ttg gcc aag gca gtc cag aac gtg ggc aac atg gac acg ccg gct     1591
 Leu Leu Ala Lys Ala Val Gln Asn Val Gly Asn Met Asp Thr Pro Ala
             505                 510                 515

 tcc agg gcc aag gag gct tgg atg gag ccg ctg cag ccc acc gtg cgc     1639
 Ser Arg Ala Lys Glu Ala Trp Met Glu Pro Leu Gln Pro Thr Val Arg
         520                 525                 530

 cag ggc gtg gcg cag ctg aag gac ttc atc acc aag ctc gtg gac atc     1687
 Gln Gly Val Ala Gln Leu Lys Asp Phe Ile Thr Lys Leu Val Asp Ile
     535                 540                 545

 gag gag aag gac gag ctg gac ctg cag cgg acg ctg agt ttg cag gcg     1735
 Glu Glu Lys Asp Glu Leu Asp Leu Gln Arg Thr Leu Ser Leu Gln Ala
 550                 555                 560                 565

 cca cct gtg aag gag ggg cca ctc ttc atc cac agg acc aag ggc aag     1783
 Pro Pro Val Lys Glu Gly Pro Leu Phe Ile His Arg Thr Lys Gly Lys
                 570                 575                 580

 ggc ccc ctc atg tcc tcc tcc ttc aag aag ctc tac ttc tcc ctc act     1831
 Gly Pro Leu Met Ser Ser Ser Phe Lys Lys Leu Tyr Phe Ser Leu Thr
             585                 590                 595

 acc gag gcc ctc agc ttc gcg aag atg ccc agc tcc aag aaa agc gcc     1879
 Thr Glu Ala Leu Ser Phe Ala Lys Met Pro Ser Ser Lys Lys Ser Ala
         600                 605                 610

 ctc atc aag tta gcc aac atc cgg gca gcg gaa aag gtt gag gaa aag     1927
 Leu Ile Lys Leu Ala Asn Ile Arg Ala Ala Glu Lys Val Glu Glu Lys
     615                 620                 625

 agc ttt ggc ggc tcg cac gtc atg cag gtc atc tac acg gac gac gcc     1975
 Ser Phe Gly Gly Ser His Val Met Gln Val Ile Tyr Thr Asp Asp Ala
 630                 635                 640                 645

 ggc agg ccc cag act gcc tac ctg cag tgc aag tgt gtg aat gag ctt     2023
 Gly Arg Pro Gln Thr Ala Tyr Leu Gln Cys Lys Cys Val Asn Glu Leu
                 650                 655                 660

 aac cag tgg ctg tct gcg ctg cgg aag gtg agc atc aac aac acc gga     2071
 Asn Gln Trp Leu Ser Ala Leu Arg Lys Val Ser Ile Asn Asn Thr Gly
             665                 670                 675

 ctg ctg ggc tcc tac cac cct ggc gtc ttc cgt ggg gac aag tgg agc     2119
 Leu Leu Gly Ser Tyr His Pro Gly Val Phe Arg Gly Asp Lys Trp Ser
         680                 685                 690

 tgc tgc cac caa aaa gag aag aca ggt cag ggc tgc gat aag acc cgg     2167
 Cys Cys His Gln Lys Glu Lys Thr Gly Gln Gly Cys Asp Lys Thr Arg
     695                 700                 705

 tca cgg gtg acc ctg cag gag tgg aat gac cct ctt gac cat gac ctt     2215
 Ser Arg Val Thr Leu Gln Glu Trp Asn Asp Pro Leu Asp His Asp Leu
 710                 715                 720                 725

 gag gcc cag ctc atc tac cgg cac ctg ctg ggc gtg gag gcc atg ctg     2263
 Glu Ala Gln Leu Ile Tyr Arg His Leu Leu Gly Val Glu Ala Met Leu
                 730                 735                 740

 tgg gag agg cac cgg gag ctg agc ggg ggc aca gag gca ggc acg gtg     2311
 Trp Glu Arg His Arg Glu Leu Ser Gly Gly Thr Glu Ala Gly Thr Val
             745                 750                 755

 ccc acg agc cct ggc aaa gtc ccc gag gac tca ttg gcc cgg ctg ctc     2359
 Pro Thr Ser Pro Gly Lys Val Pro Glu Asp Ser Leu Ala Arg Leu Leu
         760                 765                 770

 cgg gtg ctg cag gac ctc cgc gag gcc cat agc tcc agc ccg gcc ggc     2407
 Arg Val Leu Gln Asp Leu Arg Glu Ala His Ser Ser Ser Pro Ala Gly
     775                 780                 785

 tcc cca ccc tca gag ccc aac tgc ctc ctg gag ctg cag acg tga ggc     2455
 Ser Pro Pro Ser Glu Pro Asn Cys Leu Leu Glu Leu Gln Thr 
 790                 795                 800

 ccgccctacg ctccccttgc tgagtcccct gccaagcgct cggagccccc ccaggacact   2515

 ctgcaccccc tcaccccggt cctcctcatt agggtgcagg gcctaggtct cttccaggtg   2575

 ggggaggggg gagagtcagg aataagggga tccccagaag tgcagagctg agcaggcttg   2635

 ggcctgtcat ggctggccgg aagtgtcccc agctccctac agacgctgta gccatcactg   2695

 cctctccagg gaccctcctc tcctgcccag gacagaccca gccagaacca ctgctaggat   2755

 gggccgcacc caggggtctg gcctccaggg acctagagaa tgggagggag aacggggccc   2815

 caggagaccc ggccgccacc ccacccgcta cccttgggtg ccacagggct gtgctgttgc   2875

 caacagtaaa cctgctctta ctgtccaggc tctggggtct tgtgatgagg gtctggggag   2935

 aaagtgggcc cggggggacc ccggaggctg tcggtggatg tgccgatgat ggggctgaca   2995

 gtatgggctc tgggcatccc tgttcccccc cctttcttcc ccccactctt ctggggtcgg   3055

 gggttccttt cccttcccag ttgctgtccc tgggtcccct ctttcatgtc ccacaggcca   3115

 cagagcccag tgtgtccaac cagctgttct ctcctcaaag cagcccccaa gcaagtccct   3175

 tctctagggt gtccctgagg acagcacaga ggcgggactc agagacccca ttcctcttca   3235

 cgcagccctt accccaagcc ctctagctgt gtggctggca gtgttggcca cgtaggggct   3295

 cccatccccc caccattgtg tcacatgggc tgccaggctc agctcccagc tgcgtccaca   3355

 gtgacctgga tcagggtggg gacaaggact ggaccctcct tctccagaag gccttcagct   3415

 cttgccttgc catgcagtca cctccttccc cctctgaccc cagatcccaa aggtgcaccg   3475

 ttgccccagc ccctttctgg ccccatgggg tttctctgat gccttcatca tagaggcccg   3535

 gggctggtcc gatggttggc aaaacttgac tccggcccag tccccactct tggggactta   3595

 gaacccctgc tgtcctggga tctggcctgc ctttctttgg tcagtccctg tggtccccca   3655

 ccagctcccc ctcccatagg gctgcccacc aagccctgcc cccagcccaa gaggagcccc   3715

 cactgcctgc ggggcagtga tgtctggcca ccggctcaca ccaatgactt ggtcctgggg   3775

 tggcagaagc agcaggtgac aggagcaggg cccctgtccc tctcttctgg ccctgtggta   3835

 cccaggccac acgttgtgcc cgctcttggg gctgaccggc tgtagggacc accagccgct   3895

 gctactgtgg gccgccccgg ggcagggtgg gcagggcttt tgtgggttat gaggacacag   3955

 aagtccctga ggcccccaga cctggctcag ccaacctcct tcctcccccg gttgcccccc   4015

 actctaaagc ctcctccctc ccagcgtcca ctggctccag gctcctcaca acagcagctc   4075

 atagacacgg ggcgtctcca ggtggtccca gccctccaga tgtttctagc tctccaggtg   4135

 ggcgctgttt tcacgtctgc ctgcatccat tcattccttc attcctcacc tttatcctgt   4195

 tatctctatt tttttaagct accaggaagg aaagggaaga agagatcacg aaactgggac   4255

 ccccagaagg gaggagtggg ctttgaactt agacatctac ctcagagctc aaataggttg   4315

 tttaaaatca cattcaattt tcagatgaag gggaac                             4351




      <210> 452
      <211> 1455
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (274)..(966)

      <220>
      <221> misc_feature
      <222> (1)...(1455)
      <223> n = a,t,c or g

      <400> 452
 ctccagtttg gacgaggcct tagaggcatc agcgtatcac tttcctcgta agtcgggagt     60

 gatggaacga ccaccctgta gtgcggttgt gagaattgag atgaggcttg gctcatattg    120

 agtgctcagc tttcctggct tatagacagt ggaggggcgt ggccccacca tgcaccccaa    180

 gggtctcaga ctcaagggcc agcaggagga gttggcgggg agccttgggc ccctctggcc    240

 tcagccggat ttcccagcca aacgcagaga gag atg ccc tgg acc atc ttg ctc     294
                                      Met Pro Trp Thr Ile Leu Leu
                                        1               5

 ttt gca gct ggc tcc ttg gcg atc cca gca cca tcc atc cgg ctg gtg      342
 Phe Ala Ala Gly Ser Leu Ala Ile Pro Ala Pro Ser Ile Arg Leu Val
          10                  15                  20

 ccc ccg tac cca agc agc caa gag gac ccc atc cac atc gca tgc atg      390
 Pro Pro Tyr Pro Ser Ser Gln Glu Asp Pro Ile His Ile Ala Cys Met
      25                  30                  35

 gcc cct ggg aac ttc ccg ggg gcg aat ttc aca ctg tat cga ggg ggg      438
 Ala Pro Gly Asn Phe Pro Gly Ala Asn Phe Thr Leu Tyr Arg Gly Gly
  40                  45                  50                  55

 cag gtg gtc cag ctc ctg cag gcc ccc acg gac cag cgc ggg gtg aca      486
 Gln Val Val Gln Leu Leu Gln Ala Pro Thr Asp Gln Arg Gly Val Thr
                  60                  65                  70

 ttt aac ctg agc ggc ggc agc agc aag gct cca ggg gga ccc ttc cac      534
 Phe Asn Leu Ser Gly Gly Ser Ser Lys Ala Pro Gly Gly Pro Phe His
              75                  80                  85

 tgc cag tat gga gtg tta ggt gag ctc aac cag tcc cag ctg tca gac      582
 Cys Gln Tyr Gly Val Leu Gly Glu Leu Asn Gln Ser Gln Leu Ser Asp
          90                  95                 100

 ctc agc gag ccc gtg aac gtc tcc ttc cca gtg ccc act tgg atc ttg      630
 Leu Ser Glu Pro Val Asn Val Ser Phe Pro Val Pro Thr Trp Ile Leu
     105                 110                 115

 gtg ctc tcc ctg agc ctg gct ggt gcc ctc ttc ctc ctt gct ggg ctg      678
 Val Leu Ser Leu Ser Leu Ala Gly Ala Leu Phe Leu Leu Ala Gly Leu
 120                 125                 130                 135

 gtg gct gtt gcc ctg gtg gtc aga aaa gtt aaa ctc aga aat tta cag      726
 Val Ala Val Ala Leu Val Val Arg Lys Val Lys Leu Arg Asn Leu Gln
                 140                 145                 150

 aag aaa aga gat cga gaa tcc tgc tgg gcc cag att aac ttc gac agc      774
 Lys Lys Arg Asp Arg Glu Ser Cys Trp Ala Gln Ile Asn Phe Asp Ser
             155                 160                 165

 aca gac atg tcc ttc gat aac tcc ctg ttt acc gtc tcc gcg aaa acg      822
 Thr Asp Met Ser Phe Asp Asn Ser Leu Phe Thr Val Ser Ala Lys Thr
         170                 175                 180

 atg cca gaa gaa gac ccg gcc acc ttg gat gat cac tca ggc acc act      870
 Met Pro Glu Glu Asp Pro Ala Thr Leu Asp Asp His Ser Gly Thr Thr
     185                 190                 195

 gcc acc ccc agc aac tcc agg acc cgg aag agg ccc act tcc acg tcc      918
 Ala Thr Pro Ser Asn Ser Arg Thr Arg Lys Arg Pro Thr Ser Thr Ser
 200                 205                 210                 215

 tcc tcg cct gag acc ccc gaa ttc agc act ttc cgg gcc tgc cag tga      966
 Ser Ser Pro Glu Thr Pro Glu Phe Ser Thr Phe Arg Ala Cys Gln 
                 220                 225                 230

 ggctgaggac tgggggaccc ctctgtctcc aggcattcgg gggcctgagg tccctccagc   1026

 tacttctggg ggggctctgt cagccacttt ctcagggaat tggacagagg aaaggaaggg   1086

 gaaccctggc cttgggattt tcatcacaga ggagtgggag aggggacaca ggcatgggcc   1146

 tggcactata cagacaacag gaagttcccc tctcgacctt cggctcctca ggaccaccag   1206

 agaaggagat gtcaggaccc cttcttgtcc cccagctggg ccataagacg tcccaggtct   1266

 ctgcacaccc gtggaattcc tcccttcccc agtgggtttt tgagcatagg gtgcccttgg   1326

 gtgtgttgtg tgtctgcctg ctggcttgct taagttatta atctcagaac aacgacagcg   1386

 gccgctctag aggatccaag cttacgtacg cgtgcatgcc catgaactta atngnangag   1446

 cggggggcg                                                           1455




      <210> 453
      <211> 1989
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (202)..(1989)

      <400> 453
 ggagggggct ccgggcgccg cgcagcagac ctgctccggc cgcgcgcctc gccgctgtcc     60

 tccgggagcg gcagcagtag cccgggcggc gagggctggg ggttcctcga gactctcaga    120

 ggggcgcctc ccatcggcgc ccaccacccc aacctgttcc tcgcgcgcca ctgcgctgcg    180

 ccccaggacc cgctgcccaa c  atg gat ttt ctc ctg gcg ctg gtg ctg gta     231
                          Met Asp Phe Leu Leu Ala Leu Val Leu Val
                            1               5                  10

 tcc tcg ctc tac ctg cag gcg gcc gcc gag ttc gac ggg agg tgg ccc      279
 Ser Ser Leu Tyr Leu Gln Ala Ala Ala Glu Phe Asp Gly Arg Trp Pro
                  15                  20                  25

 agg caa ata gtg tca tcg att ggc cta tgt cgt tat ggt ggg agg att      327
 Arg Gln Ile Val Ser Ser Ile Gly Leu Cys Arg Tyr Gly Gly Arg Ile
              30                  35                  40

 gac tgc tgc tgg ggc tgg gct cgc cag tct tgg gga cag tgt cag cct      375
 Asp Cys Cys Trp Gly Trp Ala Arg Gln Ser Trp Gly Gln Cys Gln Pro
          45                  50                  55

 gtg tgc caa cca cga tgc aaa cat ggt gaa tgt atc ggg cca aac aag      423
 Val Cys Gln Pro Arg Cys Lys His Gly Glu Cys Ile Gly Pro Asn Lys
      60                  65                  70

 tgc aag tgt cat cct ggt tat gct gga aaa acc tgt aat caa gac gag      471
 Cys Lys Cys His Pro Gly Tyr Ala Gly Lys Thr Cys Asn Gln Asp Glu
  75                  80                  85                  90

 cac atc cca gct cct ctt gac caa ggc agt gaa cag cct ctt ttc caa      519
 His Ile Pro Ala Pro Leu Asp Gln Gly Ser Glu Gln Pro Leu Phe Gln
                  95                 100                 105

 ccc ctg gat cac caa gcc aca agt ttg cct tca agg gat cta aat gag      567
 Pro Leu Asp His Gln Ala Thr Ser Leu Pro Ser Arg Asp Leu Asn Glu
             110                 115                 120

 tgt ggc ctg aag ccc cgg ccc tgt aag cac agg tgc atg aac act tac      615
 Cys Gly Leu Lys Pro Arg Pro Cys Lys His Arg Cys Met Asn Thr Tyr
         125                 130                 135

 ggc agc tac aag tgc tac tgt ctc aac gga tat atg ctc atg ccg gat      663
 Gly Ser Tyr Lys Cys Tyr Cys Leu Asn Gly Tyr Met Leu Met Pro Asp
     140                 145                 150

 ggt tcc tgc tca agt gcc ctg acc tgc tcc atg gca aac tgt cag tat      711
 Gly Ser Cys Ser Ser Ala Leu Thr Cys Ser Met Ala Asn Cys Gln Tyr
 155                 160                 165                 170

 ggc tgt gat gtt gtt aaa gga caa ata cgg tgc cag tgc cca tcc cct      759
 Gly Cys Asp Val Val Lys Gly Gln Ile Arg Cys Gln Cys Pro Ser Pro
                 175                 180                 185

 ggc ctg cag ctg gct cct gat ggg agg acc tgt gta gat gtt gat gaa      807
 Gly Leu Gln Leu Ala Pro Asp Gly Arg Thr Cys Val Asp Val Asp Glu
             190                 195                 200

 tgt gct aca gga aga gcc tcc tgc cct aga ttt agg caa tgt gtc aac      855
 Cys Ala Thr Gly Arg Ala Ser Cys Pro Arg Phe Arg Gln Cys Val Asn
         205                 210                 215

 act ttt ggg agc tac atc tgc aag tgt cat aaa ggc ttc gat ctc atg      903
 Thr Phe Gly Ser Tyr Ile Cys Lys Cys His Lys Gly Phe Asp Leu Met
     220                 225                 230

 tat att gga ggc aaa tat caa tgt cat gac ata gac gaa tgc tca ctt      951
 Tyr Ile Gly Gly Lys Tyr Gln Cys His Asp Ile Asp Glu Cys Ser Leu
 235                 240                 245                 250

 ggt cag tat cag tgc agc agc ttt gct cga tgt tat aac gta cgt ggg      999
 Gly Gln Tyr Gln Cys Ser Ser Phe Ala Arg Cys Tyr Asn Val Arg Gly
                 255                 260                 265

 tcc tac aag tgc aaa tgt aaa gaa gga tac cag ggt gat gga ctg act     1047
 Ser Tyr Lys Cys Lys Cys Lys Glu Gly Tyr Gln Gly Asp Gly Leu Thr
             270                 275                 280

 tgt gtg tat atc cca aaa gtt atg att gaa cct tca ggt cca att cat     1095
 Cys Val Tyr Ile Pro Lys Val Met Ile Glu Pro Ser Gly Pro Ile His
         285                 290                 295

 gta cca aag gga aat ggt acc att tta aag ggt gac aca gga aat aat     1143
 Val Pro Lys Gly Asn Gly Thr Ile Leu Lys Gly Asp Thr Gly Asn Asn
     300                 305                 310

 aat tgg att cct gat gtt gga agt act tgg tgg cct ccg aag aca cca     1191
 Asn Trp Ile Pro Asp Val Gly Ser Thr Trp Trp Pro Pro Lys Thr Pro
 315                 320                 325                 330

 tat att cct cct atc att acc aac agg cct act tct aag cca aca aca     1239
 Tyr Ile Pro Pro Ile Ile Thr Asn Arg Pro Thr Ser Lys Pro Thr Thr
                 335                 340                 345

 aga cct aca cca aag cca aca cca att cct act cca cca cca cca cca     1287
 Arg Pro Thr Pro Lys Pro Thr Pro Ile Pro Thr Pro Pro Pro Pro Pro
             350                 355                 360

 ccc ctg cca aca gag ctc aga aca cct cta cca cct aca acc cca gaa     1335
 Pro Leu Pro Thr Glu Leu Arg Thr Pro Leu Pro Pro Thr Thr Pro Glu
         365                 370                 375

 agg cca acc acc gga ctg aca act ata gca cca gct gcc agt aca cct     1383
 Arg Pro Thr Thr Gly Leu Thr Thr Ile Ala Pro Ala Ala Ser Thr Pro
     380                 385                 390

 cca gga ggg att aca gtt gac aac agg gta cag aca gac cct cag aaa     1431
 Pro Gly Gly Ile Thr Val Asp Asn Arg Val Gln Thr Asp Pro Gln Lys
 395                 400                 405                 410

 ccc aga gga gat gtg ttc att cca cgg caa cct tca aat gac ttg ttt     1479
 Pro Arg Gly Asp Val Phe Ile Pro Arg Gln Pro Ser Asn Asp Leu Phe
                 415                 420                 425

 gaa ata ttt gaa ata gaa aga gga gtc agt gca gac gat gaa gca aag     1527
 Glu Ile Phe Glu Ile Glu Arg Gly Val Ser Ala Asp Asp Glu Ala Lys
             430                 435                 440

 gat gat cca ggt gtt ctg gta cac agt tgt aat ttt gac cat gga ctt     1575
 Asp Asp Pro Gly Val Leu Val His Ser Cys Asn Phe Asp His Gly Leu
         445                 450                 455

 tgt gga tgg atc agg gag aaa gac aat gac ttg cac tgg gaa cca atc     1623
 Cys Gly Trp Ile Arg Glu Lys Asp Asn Asp Leu His Trp Glu Pro Ile
     460                 465                 470

 agg gac cca gca ggt gga caa tat ctg aca gtg tcg gca gcc aaa gcc     1671
 Arg Asp Pro Ala Gly Gly Gln Tyr Leu Thr Val Ser Ala Ala Lys Ala
 475                 480                 485                 490

 cca ggg gga aaa gct gca cgc ttg gtg cta cct ctc ggc cgc ctc atg     1719
 Pro Gly Gly Lys Ala Ala Arg Leu Val Leu Pro Leu Gly Arg Leu Met
                 495                 500                 505

 cat tca ggg gac ctg tgc ctg tca ttc agg cac aag gtg acg ggg ctg     1767
 His Ser Gly Asp Leu Cys Leu Ser Phe Arg His Lys Val Thr Gly Leu
             510                 515                 520

 cac tct ggc aca ctc cag gtg ttt gtg aga aaa cac ggt gcc cac gga     1815
 His Ser Gly Thr Leu Gln Val Phe Val Arg Lys His Gly Ala His Gly
         525                 530                 535

 gca gcc ctg tgg gga aga aat ggt ggc cat ggc tgg agg caa aca cag     1863
 Ala Ala Leu Trp Gly Arg Asn Gly Gly His Gly Trp Arg Gln Thr Gln
     540                 545                 550

 atc acc ttg cga ggg gct gac atc aag agc gtc gtc ttc aaa ggt gaa     1911
 Ile Thr Leu Arg Gly Ala Asp Ile Lys Ser Val Val Phe Lys Gly Glu
 555                 560                 565                 570

 aaa agg cgt ggt cac act ggg gag att gga tta gat gat gtg agc ttg     1959
 Lys Arg Arg Gly His Thr Gly Glu Ile Gly Leu Asp Asp Val Ser Leu
                 575                 580                 585

 aaa aaa ggc cac tgc tct gaa gaa cgc taa                             1989
 Lys Lys Gly His Cys Ser Glu Glu Arg 
             590                 595





      <210> 454
      <211> 4499
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (982)..(2472)

      <400> 454
 agcgggggcg gagcgaggcc aggtagggtg agcggcctcc gaagcggagc ggggctctga     60

 ggagacactt tttttttcct ccctccttcc ctcctctcct cctcccttcc cttcccctct    120

 cctcccctct ctcctccttc ccccctcggt ccgccggagc ctgctggggc gagcggttgg    180

 tattgcaggc gcttgctctc cggggccgcc cggcgggtag ctggcggggg gaggaggcag    240

 gaaccgcgat ggcgcctcag aagcacggcg gtgggggagg gggcggctcg gggcccagcg    300

 cggggtccgg gggaggcggc ttcgggggtt cggcggcggt ggcggcggcg acggcttcgg    360

 gcggcaaatc cggcggcggg agctgtggag ggggtggcag ttactcggcc tcctcctcct    420

 cctccgcggc ggcagcggcg ggggctgcgg tgttaccggt gaagaagccg aaaatggagc    480

 acgtccaggc tgaccacgag cttttcctcc aggcctttga gaagccaaca cagatctata    540

 gatttcttcg aactcggaat ctcatagcac caatattttt gcacagaact cttacttaca    600

 tgtctcatcg aaactccaga acaaacatca aaaggaaaac atttaaagtt gatgatatgt    660

 tatcaaaagt agagaaaatg aaaggagagc aagaatctca taggctgtgg tcagctcatt    720

 tgcagcttac gtttactggt ttcttccagc aaaaatgata agccatcacc aaactcagaa    780

 aatgaacaaa attctgttac cctggaagtc ctgcttgtga aagtttgcca caaaaaaaga    840

 aaggatgtaa gttgtccaat aaggcaagtt cccacaggta aaaagcaggt gcctttgatt    900

 cctgacctca atcaaacaaa acccggaaat ttcccgtccc ttgcagtttc cagtaatgaa    960

 tttgaaccta gtaacagcca t  atg gtg aag tct tac tcg ttg cta ttt aga    1011
                          Met Val Lys Ser Tyr Ser Leu Leu Phe Arg
                            1               5                  10

 gtg act cgt cca gga aga aga gag ttt aat gga atg att aat gga gaa     1059
 Val Thr Arg Pro Gly Arg Arg Glu Phe Asn Gly Met Ile Asn Gly Glu
                  15                  20                  25

 acc aat gaa aat att gat gtc aat gaa gag ctt cca gcc aga aga aaa     1107
 Thr Asn Glu Asn Ile Asp Val Asn Glu Glu Leu Pro Ala Arg Arg Lys
              30                  35                  40

 cga aat cgt gag gat ggg gaa aag aca ttt gtt gca caa atg aca gta     1155
 Arg Asn Arg Glu Asp Gly Glu Lys Thr Phe Val Ala Gln Met Thr Val
          45                  50                  55

 ttt gat aaa aac agg cgc tta cag ctt tta gat ggg gaa tat gaa gta     1203
 Phe Asp Lys Asn Arg Arg Leu Gln Leu Leu Asp Gly Glu Tyr Glu Val
      60                  65                  70

 gcc atg cag gaa atg gaa gaa tgt cca ata agc aag aaa aga gca aca     1251
 Ala Met Gln Glu Met Glu Glu Cys Pro Ile Ser Lys Lys Arg Ala Thr
  75                  80                  85                  90

 tgg gag act att ctt gat ggg aag agg ctg cct cca ttc gaa aca ttt     1299
 Trp Glu Thr Ile Leu Asp Gly Lys Arg Leu Pro Pro Phe Glu Thr Phe
                  95                 100                 105

 tct cag gga cct acg ttg cag ttc act ctt cgt tgg aca gga gag acc     1347
 Ser Gln Gly Pro Thr Leu Gln Phe Thr Leu Arg Trp Thr Gly Glu Thr
             110                 115                 120

 aat gat aaa tct acg gct cct att gcc aaa cct ctt gcc act aga aat     1395
 Asn Asp Lys Ser Thr Ala Pro Ile Ala Lys Pro Leu Ala Thr Arg Asn
         125                 130                 135

 tca gag agt ctc cat cag gaa aac aag cct ggt tca gtt aaa cct act     1443
 Ser Glu Ser Leu His Gln Glu Asn Lys Pro Gly Ser Val Lys Pro Thr
     140                 145                 150

 caa act att gct gtt aaa gaa tca ttg act aca gat cta caa aca aga     1491
 Gln Thr Ile Ala Val Lys Glu Ser Leu Thr Thr Asp Leu Gln Thr Arg
 155                 160                 165                 170

 aaa gaa aag gat act cca aat gaa aac cga caa aaa tta aga ata ttt     1539
 Lys Glu Lys Asp Thr Pro Asn Glu Asn Arg Gln Lys Leu Arg Ile Phe
                 175                 180                 185

 tat cag ttt ctc tat aac aac aat aca agg caa caa act gaa gca aga     1587
 Tyr Gln Phe Leu Tyr Asn Asn Asn Thr Arg Gln Gln Thr Glu Ala Arg
             190                 195                 200

 gat gac ctg cat tgc cct tgg tgt act ctg aac tgc cgc aaa ctt tat     1635
 Asp Asp Leu His Cys Pro Trp Cys Thr Leu Asn Cys Arg Lys Leu Tyr
         205                 210                 215

 agt tta ctc aag cat ctt aaa ctc tgc cat agc aga ttt atc ttc aac     1683
 Ser Leu Leu Lys His Leu Lys Leu Cys His Ser Arg Phe Ile Phe Asn
     220                 225                 230

 tat gtt tat cat cca aaa ggt gct agg ata gat gtt tct atc aat gag     1731
 Tyr Val Tyr His Pro Lys Gly Ala Arg Ile Asp Val Ser Ile Asn Glu
 235                 240                 245                 250

 tgt tat gat ggc tcc tat gca gga aat cct cag gat att cat cgc caa     1779
 Cys Tyr Asp Gly Ser Tyr Ala Gly Asn Pro Gln Asp Ile His Arg Gln
                 255                 260                 265

 cct gga ttt gct ttt agt cgc aac gga cca gtt aag aga aca cct atc     1827
 Pro Gly Phe Ala Phe Ser Arg Asn Gly Pro Val Lys Arg Thr Pro Ile
             270                 275                 280

 aca cat att ctt gtg tgc agg cca aaa cga aca aaa gca agc atg tct     1875
 Thr His Ile Leu Val Cys Arg Pro Lys Arg Thr Lys Ala Ser Met Ser
         285                 290                 295

 gaa ttt ctt gaa tct gaa gat ggg gaa gta gaa cag caa aga aca tat     1923
 Glu Phe Leu Glu Ser Glu Asp Gly Glu Val Glu Gln Gln Arg Thr Tyr
     300                 305                 310

 agt agt ggc cac aat cgt ctg tat ttc cat agt gat acc tgc tta cct     1971
 Ser Ser Gly His Asn Arg Leu Tyr Phe His Ser Asp Thr Cys Leu Pro
 315                 320                 325                 330

 ctc cgt cca caa gaa atg gaa gta gat agt gaa gat gaa aag gat cct     2019
 Leu Arg Pro Gln Glu Met Glu Val Asp Ser Glu Asp Glu Lys Asp Pro
                 335                 340                 345

 gaa tgg cta aga gaa aaa acc att aca caa att gaa gag ttt tct gat     2067
 Glu Trp Leu Arg Glu Lys Thr Ile Thr Gln Ile Glu Glu Phe Ser Asp
             350                 355                 360

 gtt aat gaa gga gag aaa gaa gtg atg aaa ctc tgg aat ctc cat gtc     2115
 Val Asn Glu Gly Glu Lys Glu Val Met Lys Leu Trp Asn Leu His Val
         365                 370                 375

 atg aag cat ggg ttt att gct gac aat caa atg aat cat gcc tgt atg     2163
 Met Lys His Gly Phe Ile Ala Asp Asn Gln Met Asn His Ala Cys Met
     380                 385                 390

 ctg ttt gta gaa aat tat gga cag aaa ata att aag aag aat tta tgt     2211
 Leu Phe Val Glu Asn Tyr Gly Gln Lys Ile Ile Lys Lys Asn Leu Cys
 395                 400                 405                 410

 cga aac ttc atg ctt cat cta gtc agc atg cat gac ttt aat ctt att     2259
 Arg Asn Phe Met Leu His Leu Val Ser Met His Asp Phe Asn Leu Ile
                 415                 420                 425

 agc ata atg tca ata gat aaa gct gtt acc aag ctc cgt gaa atg cag     2307
 Ser Ile Met Ser Ile Asp Lys Ala Val Thr Lys Leu Arg Glu Met Gln
             430                 435                 440

 caa aaa tta gaa aag ggg gaa tct gct tcc cct gca aac gaa gaa ata     2355
 Gln Lys Leu Glu Lys Gly Glu Ser Ala Ser Pro Ala Asn Glu Glu Ile
         445                 450                 455

 act gaa gaa caa aat ggg aca gca aat gga ttt agt gaa att aac tca     2403
 Thr Glu Glu Gln Asn Gly Thr Ala Asn Gly Phe Ser Glu Ile Asn Ser
     460                 465                 470

 aaa gag aaa gct ttg gaa aca gat agt gtc tca ggg gtt tca aaa cag     2451
 Lys Glu Lys Ala Leu Glu Thr Asp Ser Val Ser Gly Val Ser Lys Gln
 475                 480                 485                 490

 agc aaa aaa caa aaa ctc tga aa agctctaacc ccatgttatg gacaaacact     2504
 Ser Lys Lys Gln Lys Leu 
                 495

 gaaattacat tttagggaat tcatcctcta agaattatgt ttttgttttt aatcatatgt   2564

 tccaaacagg cactgttaga tgaagtaaat gatttcaaca aggatatttg tatcagggtt   2624

 ctacttcact tcattatgca gcattacatg tatatcactt ttattgatgt cattaaaaca   2684

 ttctgtactt taagcatgaa aagcaatatt tcaaagtatt tttaaactca acaaatgtca   2744

 tcaaatatgt tgaattgatc tagaaattat ttcatatata aatcagaatt tttttgcatt   2804

 tatgaacggc tgtttttcta ctttgtaatt gtgagacatt ttcttgggga gggaaaattg   2864

 gaatggttcc cttttttaga aattgaagtg gtcttcatat gtcaactaca gaaaaggaaa   2924

 aaaatagaaa ttgaaggatt tttatgaaat tatattgcat tactatttgc agtcaaactt   2984

 tgatccttgt ttttgaaatc atttgtcaat tcggaatgaa aaattataat gtaattttac   3044

 attacataag ttccttttac aattaaaaaa tagcacttct tcatcttatg cctgtttgag   3104

 aagatattaa attttcacat tgttgacagt gaaatgctat gttggtttat aagattacag   3164

 accatttgtt ttcatgtgga taattttagt gcattgctca cccggtatgt tttttttttt   3224

 taacttgaac attttgcttg ttttgttttt cttttttaat tagataatca cacggaaaat   3284

 taagctgttc atatctttaa attaggattg caaaccaagg aaagaacgca tttgagattt   3344

 taagatgtca cttataaggg gagaagtgtt cttaaaaagt caaccagaaa actgttatgc   3404

 cttttatttg tttgcaagga tgtctttgta atgtgtttca tgaatagaat atccaataga   3464

 gataagctga cttgaatcat tttgagcaat tttgccctgt gttatatgtg tttcacgcac   3524

 atatttgcag ttggattttc tccaacagaa agtggattca ctactggcac attaacaagc   3584

 accaataggt ttttattcca actccgagca ctgtggttga gtaacatcac ctcaattttt   3644

 tattatcctt aaagatattg cattttcata ttctttattt ataaaggatc aatgctgctg   3704

 taaatacagg tatttttaat tttaaaattt cattccacca ccatcagatg cagttcccta   3764

 ttttgtttaa tgaagggata tataagcttt ctaatggtgt cttcagaaat ttataaaatg   3824

 taaatactga tttgactggt ctttaagatg tgtttaactg tgaggctatt taacgaatag   3884

 tgtggatgtg atttgtcatc cagtattaag ttcttagtca ttgatttttg tgtttaaaaa   3944

 aaaataggaa agagggaaac tgcagctttc attacagatt ccttgattgg taagctctcc   4004

 aaatgatgag ttctagtaaa ctctgatttt tgcctctgga tagtagatct cgagcgttta   4064

 tctcgggctt taatttgcta aagctgtgca catatgtaaa aaaaaaaaaa aaaagattat   4124

 tttaggggag atgtaggtgt agaattattg cttatgtcat ttcttaagca gttatgctct   4184

 taatgcttaa aagaaggcta gcattgtttg cacaaaaagt tggtgattcc caccccaaat   4244

 agtaataaaa ttacttctgt tgagtaaact ttttatgtca tcgtaaaagc tggaaaaatc   4304

 cctttgtttc tatttataaa aaaagtgctt ttctatatgt acccttgata acagattttg   4364

 aagaaatcct gtaagatgat aaagcatttg aatggtacag tagatgtaaa aaaaattcag   4424

 tttaaaagaa catttgtttt tacattaaat gtttatttga aatcaaatga ttttgtacat   4484

 aaagttcaat aatat                                                    4499




      <210> 455
      <211> 468
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(468)

      <400> 455
  atg ctg ggg ctg ctg gtg gcg ttg ctg gcc ctg ggg ctc gct gtc ttt      48
  Met Leu Gly Leu Leu Val Ala Leu Leu Ala Leu Gly Leu Ala Val Phe
    1               5                  10                  15

 gcg ctg ctg gac gtc tgg tac ctg gtg cgc ctt ccg tgc gcc gtg ctg       96
 Ala Leu Leu Asp Val Trp Tyr Leu Val Arg Leu Pro Cys Ala Val Leu
              20                  25                  30

 cgc gcg cgc ctg ctg cag ccg cgc gtc cgt gac ctg cta gct gag cag      144
 Arg Ala Arg Leu Leu Gln Pro Arg Val Arg Asp Leu Leu Ala Glu Gln
          35                  40                  45

 cgc ttc ccg ggc cgc gtg ctg ccc tcg gac ttg gac ctg ctg ctg cac      192
 Arg Phe Pro Gly Arg Val Leu Pro Ser Asp Leu Asp Leu Leu Leu His
      50                  55                  60

 atg aac aac gcg cgc tac ctg cgc gag gcc gac ttt gcg cgc gtc gcg      240
 Met Asn Asn Ala Arg Tyr Leu Arg Glu Ala Asp Phe Ala Arg Val Ala
  65                  70                  75                  80

 cac ctg acc cgc tgc ggg gtg ctc ggg gcg ctg agg gag ttg cgg gcg      288
 His Leu Thr Arg Cys Gly Val Leu Gly Ala Leu Arg Glu Leu Arg Ala
                  85                  90                  95

 cac acg gtg ctg gcg gcc tcg tgc gcg cgc cac cgc cgc tcg ctg cgc      336
 His Thr Val Leu Ala Ala Ser Cys Ala Arg His Arg Arg Ser Leu Arg
             100                 105                 110

 ctg ctg gag ccc ttc gag gtg gag ccc cct gag ctg ccc gct gat ctg      384
 Leu Leu Glu Pro Phe Glu Val Glu Pro Pro Glu Leu Pro Ala Asp Leu
         115                 120                 125

 cag cac tgg atc tcc tac aac gag gcc agc agc cag ctg ctc cgc atg      432
 Gln His Trp Ile Ser Tyr Asn Glu Ala Ser Ser Gln Leu Leu Arg Met
     130                 135                 140

 gag agt ggg ctc agt gat gtc acc aag gac cag tga                      468
 Glu Ser Gly Leu Ser Asp Val Thr Lys Asp Gln 
 145                 150                 155





      <210> 456
      <211> 1148
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(579)

      <400> 456
 ggtggaattc gtggagtgag tctgaggaca gcagatgaac agacagaaac tgaaagatcc     60

 ccaaaaagg    atg agt gag agg gtc gag cgg aac tgg agc acg ggc ggc     108
              Met Ser Glu Arg Val Glu Arg Asn Trp Ser Thr Gly Gly
                1               5                  10

 tgg ctg ctg gca ctg tgc ctg gcc tgg ctg tgg acc cac ctg acc ttg      156
 Trp Leu Leu Ala Leu Cys Leu Ala Trp Leu Trp Thr His Leu Thr Leu
      15                  20                  25

 gct gcc ctg cag cct ccc act gcc aca gtg ctt gtg cag cag ggc acc      204
 Ala Ala Leu Gln Pro Pro Thr Ala Thr Val Leu Val Gln Gln Gly Thr
  30                  35                  40                  45

 tgc gag gtg att gcg gct cac cgc tgc tgc aac cgg aac cgc atc gag      252
 Cys Glu Val Ile Ala Ala His Arg Cys Cys Asn Arg Asn Arg Ile Glu
                  50                  55                  60

 gag cgc tcc cag acg gtg aaa tgc tcc tgt ttt tct ggc cag gtg gcc      300
 Glu Arg Ser Gln Thr Val Lys Cys Ser Cys Phe Ser Gly Gln Val Ala
              65                  70                  75

 ggc acc acg cgg gca aag ccc tcc tgc gtg gac gac ctg ctc ttg gct      348
 Gly Thr Thr Arg Ala Lys Pro Ser Cys Val Asp Asp Leu Leu Leu Ala
          80                  85                  90

 gcc cac tgt gct cgt aga gac cct aga gct gca ctc cgc ctc ctg ctc      396
 Ala His Cys Ala Arg Arg Asp Pro Arg Ala Ala Leu Arg Leu Leu Leu
      95                 100                 105

 cca cag cct cca tcg tcc tgc aga gat ggt ggt gtc aga tgg agc cct      444
 Pro Gln Pro Pro Ser Ser Cys Arg Asp Gly Gly Val Arg Trp Ser Pro
 110                 115                 120                 125

 gcc tgc cgg ggg agg agt gta agg tgc tcc cgg acc tgt cgg gat gga      492
 Ala Cys Arg Gly Arg Ser Val Arg Cys Ser Arg Thr Cys Arg Asp Gly
                 130                 135                 140

 gct gca gca gtg gac aca aag tca aaa cca cca agg tca cac gat agc      540
 Ala Ala Ala Val Asp Thr Lys Ser Lys Pro Pro Arg Ser His Asp Ser
             145                 150                 155

 tct tgg ggg tca cgg cct gga caa gaa agg ctt gac tga gccgtgaact       589
 Ser Trp Gly Ser Arg Pro Gly Gln Glu Arg Leu Asp 
         160                 165

 gaagaatggt atccagtcat cagccaggaa agatggggat tcacttacat gcctcatgtc    649

 aaatgcagca tcagtctttc cggggcattt cagttaagct gctcagcaga tatggatgga    709

 tctgcaatca catacctaat gtggagctgg gcttttctgg agacacgaag gtcaacacac    769

 aattcctgcc cttaaggaat gtccagttga attggagagt tgatgacaga caatttagat    829

 aatttaggtt aaagtacttg ataccagact gcggcttctg ggccacatgc tatggcatga    889

 tgggggtttg ggaatgagat tcccacagtt cttcagatac cctgtggcca cagggcatag    949

 aaacaagagg tcacattcag cacccaccac ctccctcttt cgcatcagtt ctgaatcccc   1009

 agcaagctgt taacatgttg caggaaaaca ctctcccctt atgccagacc agcagtatct   1069

 catttggatg ggattggatt gacttgcgga aggaaagtaa aaataaagcc aaataacttc   1129

 ccaaaaaaaa aaaaaaaaa                                                1148




      <210> 457
      <211> 1080
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(471)

      <400> 457
 ggtggaattc gtggagtgag tctgaggaca gcagatgaac agacagaaac tgaaagatcc     60

 ccaaaaagg    atg agt gag agg gtc gag cgg aac tgg agc acg ggc ggc     108
              Met Ser Glu Arg Val Glu Arg Asn Trp Ser Thr Gly Gly
                1               5                  10

 tgg ctg ctg gca ctg tgc ctg gcc tgg ctg tgg acc cac ctg acc ttg      156
 Trp Leu Leu Ala Leu Cys Leu Ala Trp Leu Trp Thr His Leu Thr Leu
      15                  20                  25

 gct gcc ctg cag cct ccc act gcc aca gtg ctt gtg cag cag ggc acc      204
 Ala Ala Leu Gln Pro Pro Thr Ala Thr Val Leu Val Gln Gln Gly Thr
  30                  35                  40                  45

 tgc gag gtg att gcg gct cac cgc tgc tgc aac cgg aac cgc atc gag      252
 Cys Glu Val Ile Ala Ala His Arg Cys Cys Asn Arg Asn Arg Ile Glu
                  50                  55                  60

 gag cgc tcc cag acg gtg aaa tgc tcc tgt ttt tct ggc cag gtg gcc      300
 Glu Arg Ser Gln Thr Val Lys Cys Ser Cys Phe Ser Gly Gln Val Ala
              65                  70                  75

 ggc acc acg cgg gca aag ccc tcc tgc gtg gac gcc tcc atc gtc ctg      348
 Gly Thr Thr Arg Ala Lys Pro Ser Cys Val Asp Ala Ser Ile Val Leu
          80                  85                  90

 cag aga tgg tgg tgt cag atg gag ccc tgc ctg ccg ggg gag gag tgt      396
 Gln Arg Trp Trp Cys Gln Met Glu Pro Cys Leu Pro Gly Glu Glu Cys
      95                 100                 105

 aag gtg ctc ccg gac ctg tcg gga tgg agc tgc agc agt gga cac aaa      444
 Lys Val Leu Pro Asp Leu Ser Gly Trp Ser Cys Ser Ser Gly His Lys
 110                 115                 120                 125

 gtc aaa acc acc aag gtc aca cga tag ctctt gggggtcacg gcctggacaa      496
 Val Lys Thr Thr Lys Val Thr Arg 
                 130

 gaaaggcttg actgagccgt gaactgaaga atggtatcca gtcatcagcc aggaaagatg    556

 gggattcact tacatgcctc atgtcaaatg cagcatcagt ctttccgggg catttcagtt    616

 aagctgctca gcagatatgg atggatctgc aatcacatac ctaatgtgga gctgggcttt    676

 tctggagaca cgaaggtcaa cacacaattc ctgcccttaa ggaatgtcca gttgaattgg    736

 agagttgatg acagacaatt tagataattt aggttaaagt acttgatacc agactgcggc    796

 ttctgggcca catgctatgg catgatgggg gtttgggaat gagattccca cagttcttca    856

 gataccctgt ggccacaggg catagaaaca agaggtcaca ttcagcaccc accacctccc    916

 tctttcgcat cagttctgaa tccccagcaa gctgttaaca tgttgcagga aaacactctc    976

 cccttatgcc agaccagcag tatctcattt ggatgggatt ggattgactt gcggaaggaa   1036

 agtaaaaata aagccaaata acttcccaaa aaaaaaaaaa aaaa                    1080




      <210> 458
      <211> 1451
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1293)

      <400> 458
  atg ggg gac agc agg cga agg tca ctc ggg aac cag ccc agc tct gag      48
  Met Gly Asp Ser Arg Arg Arg Ser Leu Gly Asn Gln Pro Ser Ser Glu
    1               5                  10                  15

 gct gcg ggc agg tcg gaa agg gag cag gac ggc gac ccc cgt ggc ctc       96
 Ala Ala Gly Arg Ser Glu Arg Glu Gln Asp Gly Asp Pro Arg Gly Leu
              20                  25                  30

 cag agc tct gtg tac gag agc cgg cgg gtc aca gac ccc gaa cgc cag      144
 Gln Ser Ser Val Tyr Glu Ser Arg Arg Val Thr Asp Pro Glu Arg Gln
          35                  40                  45

 gac ctg gac aat gca gag ctg gga cca gaa gac cca gaa gag gag ctt      192
 Asp Leu Asp Asn Ala Glu Leu Gly Pro Glu Asp Pro Glu Glu Glu Leu
      50                  55                  60

 ccc ccc gag gag gtg gcc ggg gag gag ttc ccg gag acc ctg gat ccc      240
 Pro Pro Glu Glu Val Ala Gly Glu Glu Phe Pro Glu Thr Leu Asp Pro
  65                  70                  75                  80

 aaa gag gca ctt tct gag ttg gag aga gtc ctg gac aag gac ttg gaa      288
 Lys Glu Ala Leu Ser Glu Leu Glu Arg Val Leu Asp Lys Asp Leu Glu
                  85                  90                  95

 gag gac att cct gaa atc agt cct ccc tca gag acc cct cga ggg aag      336
 Glu Asp Ile Pro Glu Ile Ser Pro Pro Ser Glu Thr Pro Arg Gly Lys
             100                 105                 110

 gga gag gcg ggt ggg cag ggt gag tgc aga caa aag gcg ctt gag caa      384
 Gly Glu Ala Gly Gly Gln Gly Glu Cys Arg Gln Lys Ala Leu Glu Gln
         115                 120                 125

 gac cca cgc ttc tct ggg ctc cca aac gca tcg ggg cgg gaa agc agc      432
 Asp Pro Arg Phe Ser Gly Leu Pro Asn Ala Ser Gly Arg Glu Ser Ser
     130                 135                 140

 tcc aac ttc aac gtg gaa ttc tcc caa agc cgg ctg tcc atc agc cag      480
 Ser Asn Phe Asn Val Glu Phe Ser Gln Ser Arg Leu Ser Ile Ser Gln
 145                 150                 155                 160

 aag ctc ccc agc acc acc atg acc aaa gca agg aag agg agg agg cgg      528
 Lys Leu Pro Ser Thr Thr Met Thr Lys Ala Arg Lys Arg Arg Arg Arg
                 165                 170                 175

 agg agg ctc atg gag ctg gca gag ccc aag ata aac tgg caa gtc ctg      576
 Arg Arg Leu Met Glu Leu Ala Glu Pro Lys Ile Asn Trp Gln Val Leu
             180                 185                 190

 aaa gac agg aag gga cgc tgt ggt aag ggg tat gcc tgg atc tcc cca      624
 Lys Asp Arg Lys Gly Arg Cys Gly Lys Gly Tyr Ala Trp Ile Ser Pro
         195                 200                 205

 tgt aag atg agc ttg cac ttc tgt ctc tgc tgg ccc tct gtg tac tgg      672
 Cys Lys Met Ser Leu His Phe Cys Leu Cys Trp Pro Ser Val Tyr Trp
     210                 215                 220

 acc gag cgg ttc ctt gag gac acc acc ctc acc atc aca gtg ccc gcg      720
 Thr Glu Arg Phe Leu Glu Asp Thr Thr Leu Thr Ile Thr Val Pro Ala
 225                 230                 235                 240

 gtg tcc cgc cgc gtg gag gaa ctg tct cgg ccc aag aga ttc tac ctg      768
 Val Ser Arg Arg Val Glu Glu Leu Ser Arg Pro Lys Arg Phe Tyr Leu
                 245                 250                 255

 gaa tat tac aac aac aac agg acg act cct gtc tgg ccc att cct cgg      816
 Glu Tyr Tyr Asn Asn Asn Arg Thr Thr Pro Val Trp Pro Ile Pro Arg
             260                 265                 270

 tcc tcc ctg gaa tac aga gcg tcg agt cgc ctg aag gaa ctg gcc gcc      864
 Ser Ser Leu Glu Tyr Arg Ala Ser Ser Arg Leu Lys Glu Leu Ala Ala
         275                 280                 285

 ccg aag att cgt gat aac ttc tgg agc atg ccc atg tct gag gtg tcc      912
 Pro Lys Ile Arg Asp Asn Phe Trp Ser Met Pro Met Ser Glu Val Ser
     290                 295                 300

 cag gta tcc agg gca gcc caa atg gca gtc ccc agc tcg cgg atc ctc      960
 Gln Val Ser Arg Ala Ala Gln Met Ala Val Pro Ser Ser Arg Ile Leu
 305                 310                 315                 320

 cag ttg tca aag ccg aag gcc cca gcc acc ctc ttg gaa gag tgg gac     1008
 Gln Leu Ser Lys Pro Lys Ala Pro Ala Thr Leu Leu Glu Glu Trp Asp
                 325                 330                 335

 ccc gtg cca aaa ccc aag cca cat gtg tca gac cat aac cgc ctc ctt     1056
 Pro Val Pro Lys Pro Lys Pro His Val Ser Asp His Asn Arg Leu Leu
             340                 345                 350

 cac ttg gcc agg ccc aaa gct cag tcg gac aag tgc gtt cct gac cga     1104
 His Leu Ala Arg Pro Lys Ala Gln Ser Asp Lys Cys Val Pro Asp Arg
         355                 360                 365

 gat cct cgc tgg gag gtg ctg gat gtc acc aag aag gtg gtg gcc agc     1152
 Asp Pro Arg Trp Glu Val Leu Asp Val Thr Lys Lys Val Val Ala Ser
     370                 375                 380

 ccc cgg atc atc tcc ctg gcc aag ccc aaa gtg cgc aag ggc ctc aac     1200
 Pro Arg Ile Ile Ser Leu Ala Lys Pro Lys Val Arg Lys Gly Leu Asn
 385                 390                 395                 400

 gag gga tac gac agg cgt ccc ctc gcc tct atg agc ttg cca ccc cca     1248
 Glu Gly Tyr Asp Arg Arg Pro Leu Ala Ser Met Ser Leu Pro Pro Pro
                 405                 410                 415

 aaa gca tca cca gaa aag tgt gat caa ccc agg cct ggc ctc taa gac     1296
 Lys Ala Ser Pro Glu Lys Cys Asp Gln Pro Arg Pro Gly Leu 
             420                 425                 430

 ctccgctccc agtaaacacc ctcaggcacc ctaaccctgt gtatgtgatt attctgagct   1356

 ttttggcctg gagaagggag ggcgggctag aaggccaaaa gaaggatgag gaggacaata   1416

 atatttattt ttgcatccaa aaaaaaaaaa aaaaa                              1451




      <210> 459
      <211> 1788
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (833)..(1417)

      <400> 459
 atttggccct cgaggccaag aattcggcac gagggatcca aggtcaaaaa aacaaattca     60

 tcaattcagc acaccaccaa ctcacaggct aagcatctta ctgctaattc attgatgctg    120

 ccatttgtca agtgccaaat tgaattattg atttgtcaat aatttccttc cgttggttac    180

 ttatatagta tattgcaatt cttgttgctg aagtcagcta cactttttct atttgaaaaa    240

 caatttcttg catttgggat ttcaggtata gtgattgtta caaatatgaa ggacttgaat    300

 taacagcaag ttttcaagta aaactttact tatgtataac tgaatgagtt cttaaagaca    360

 tttactaaca attttccaca aactaaaaat ttataaaaca ataaataaaa tagactttaa    420

 aaaaaagcgt gtcacacagc tgcttgtttt ttgtttgttt ctttgtttgt tttttagtag    480

 tgaaatggtg aaaaatcaga caatggtcac agagttcctc ctactgggat ttctcctggg    540

 cccaaggatt cagatgctcc tctttgggct cttctccctg ttctatgtct tcaccctgct    600

 ggggaatggg accatcctgg ggctcatctc actggactcc agactccaca cccccatgta    660

 cttcttcctc tcacacctgg ccgtcgtcaa catcgcctat gcctgcaaca cagtgcccca    720

 gatgctggtg aacctcctgc atccagccaa gcccatctcc tttgctggct gcatgacata    780

 gacctttctc tttttgagtt ttgcacatac tgaatgcctc ctgttggtgc tg    atg     835
                                                              Met
                                                                1

 tcc tac gat cgg tac gtg gcc atc tgc cac cct ctc cga tat ttc atc      883
 Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Phe Ile
               5                  10                  15

 atc atg acc tgg aaa gtc tgc atc act ctg gcc atc act tcc tgg aca      931
 Ile Met Thr Trp Lys Val Cys Ile Thr Leu Ala Ile Thr Ser Trp Thr
          20                  25                  30

 tgt ggc tcc ctc ctg gct atg gtc cat gtg agc ctc atc cta aga ctg      979
 Cys Gly Ser Leu Leu Ala Met Val His Val Ser Leu Ile Leu Arg Leu
      35                  40                  45

 ccc ttt tgt ggg cct cgt gaa atc aac cac ttc ttc tgt gaa atc ctg     1027
 Pro Phe Cys Gly Pro Arg Glu Ile Asn His Phe Phe Cys Glu Ile Leu
  50                  55                  60                  65

 tct gtc ctc agg ctg gcc tgt gct gat acc tgg ctc aac cag gtg gtc     1075
 Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp Leu Asn Gln Val Val
                  70                  75                  80

 atc ttt gca gcc tgc atg ttc atc ctg gtg gga cca ctc tgc ctg gtg     1123
 Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly Pro Leu Cys Leu Val
              85                  90                  95

 ctg gtc tcc tac tca cac atc ctg gcg gcc atc ctg agg atc cag tct     1171
 Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile Leu Arg Ile Gln Ser
         100                 105                 110

 ggg gag ggc cgc aga aag gcc ttc tcc acc tgc tcc tcc cac ctc tgc     1219
 Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser His Leu Cys
     115                 120                 125

 gta gtg gga ctc ttc ttt ggc agc gcc atc gtc atg tac atg gcc cct     1267
 Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val Met Tyr Met Ala Pro
 130                 135                 140                 145

 aag tcc cgc cat cct gag gag cag cag aag gtc ctt ttt cta ttt tac     1315
 Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val Leu Phe Leu Phe Tyr
                 150                 155                 160

 agt tct ttc aac ccg atg cta aac ccc ctg att tac aac ctg agg aat     1363
 Ser Ser Phe Asn Pro Met Leu Asn Pro Leu Ile Tyr Asn Leu Arg Asn
             165                 170                 175

 gta gag gtc aag ggt gcc ctg agg aga gca ctg tgc aag gaa agt cat     1411
 Val Glu Val Lys Gly Ala Leu Arg Arg Ala Leu Cys Lys Glu Ser His
         180                 185                 190

 tcc taa gaggtgtgac atttgaactg ccagcctcag ttgtcacgtg gactcttgat      1467
 Ser 


 gcccaattat tgcctcaatc cagaaaagtt tacttctctt tatctgtgct ttactgacag   1527

 aagggcaagt cttctctcgt tttttgcaga taaaatttta gatgtgttgc attcattggg   1587

 tttctatgag atgtggtttt atcagacaat tttttctttt atttcacaat tactttaata   1647

 tctgtaaaat aaagaattat tttaattcat tttcccagtc ccaaaagtta aatacaggcc   1707

 acttacttct ttaaccaaat gatatagttt ggctctgtgt ccccacccaa atctcatgtc   1767

 aaattgtaat ccccgcatgt g                                             1788




      <210> 460
      <211> 1782
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (485)..(1411)

      <400> 460
 atttggccct cgaggccaag aattcggcac gagggatcca aggtcaaaaa aacaaattca     60

 tcaattcagc acaccaccaa ctcacaggct aagcatctta ctgctaattc attgatgctg    120

 ccatttgtca agtgccaaat tgaattattg atttgtcaat aatttccttc cgttggttac    180

 ttatatagta tattgcaatt cttgttgctg aagtcagcta cactttttct atttgaaaaa    240

 caatttcttg catttgggat ttcaggtata gtgattgtta caaatatgaa ggacttgaat    300

 taacagcaag ttttcaagta aaactttact tatgtataac tgaatgagtt cttaaagaca    360

 tttactaaca attttccaca aactaaaaat ttataaaaca ataaataaaa tagactttaa    420

 aaaaaagcgt gtcacacagc tgcttgtttt ttgtttgttt ctttgtttgt tttttagtag    480

 tgaa atg gtg aaa aat cag aca atg gtc aca gag ttc ctc cta ctg gga     529
      Met Val Lys Asn Gln Thr Met Val Thr Glu Phe Leu Leu Leu Gly
        1               5                  10                  15

 ttt ctc ctg ggc cca agg att cag atg ctc ctc ttt ggg ctc ttc tcc      577
 Phe Leu Leu Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser
                  20                  25                  30

 ctg ttc tat atc ttc acc ctg ctg ggg aac ggg gcc atc ctg ggg ctc      625
 Leu Phe Tyr Ile Phe Thr Leu Leu Gly Asn Gly Ala Ile Leu Gly Leu
              35                  40                  45

 atc tca ctg gac tcc aga ctc cat acc ccc atg tac ttc ttc ctc tca      673
 Ile Ser Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser
          50                  55                  60

 cac ctg gct gtc gtc gac atc gcc tac acc cgc aac acg gtg ccc cag      721
 His Leu Ala Val Val Asp Ile Ala Tyr Thr Arg Asn Thr Val Pro Gln
      65                  70                  75

 atg ctg gcg aac ctc ctg cat cca gcc aag ccc atc tcc ttt gct ggt      769
 Met Leu Ala Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly
  80                  85                  90                  95

 tgc atg acg cag acc ttt ctc tgt ttg agt ttt gga cac agc gaa tgt      817
 Cys Met Thr Gln Thr Phe Leu Cys Leu Ser Phe Gly His Ser Glu Cys
                 100                 105                 110

 ctc ctg ctg gtg ctg atg tcc tac gat cgt tac gtg gcc atc tgc cac      865
 Leu Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His
             115                 120                 125

 cct ctc cga tac tcc gtc atc atg acc tgc tgc atc act ctg gcc atc      913
 Pro Leu Arg Tyr Ser Val Ile Met Thr Cys Cys Ile Thr Leu Ala Ile
         130                 135                 140

 act tcc tgg aca tgt ggc tcc ctc ctg gct atg gtc cat gtg agc ctc      961
 Thr Ser Trp Thr Cys Gly Ser Leu Leu Ala Met Val His Val Ser Leu
     145                 150                 155

 atc cta aga ctg ccc ttt tgt ggg cct cgt gaa atc aac cac ttc ttc     1009
 Ile Leu Arg Leu Pro Phe Cys Gly Pro Arg Glu Ile Asn His Phe Phe
 160                 165                 170                 175

 tgt gaa atc ctg tct gtc ctc agg ctg gcc tgt gct gat acc tgg ctc     1057
 Cys Glu Ile Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp Leu
                 180                 185                 190

 aac cag gtg gtc atc ttt gca gcc tgc atg ttc atc ctg gtg gga cca     1105
 Asn Gln Val Val Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly Pro
             195                 200                 205

 ctc tgc ctg gtg ctg gtc tcc tac tca cac atc ctg gcg gcc atc ctg     1153
 Leu Cys Leu Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile Leu
         210                 215                 220

 agg atc cag tct ggg gag ggc cgc aga aag gcc ttc tcc acc tgc tcc     1201
 Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser
     225                 230                 235

 tcc cac ctc tgc gta gtg gga ctc ttc ttt ggc agc gcc atc gtc atg     1249
 Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val Met
 240                 245                 250                 255

 tac atg gcc cct aag tcc cgc cat cct gag gag cag cag aag gtc ctt     1297
 Tyr Met Ala Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val Leu
                 260                 265                 270

 ttt cta ttt tac agt tct ttc aac ccg atg cta aac ccc ctg att tac     1345
 Phe Leu Phe Tyr Ser Ser Phe Asn Pro Met Leu Asn Pro Leu Ile Tyr
             275                 280                 285

 aac ctg agg aat gta gag gtc aag ggt gcc ctg agg aga gca ctg tgc     1393
 Asn Leu Arg Asn Val Glu Val Lys Gly Ala Leu Arg Arg Ala Leu Cys
         290                 295                 300

 aag gaa agt cat tcc taa gaggtg tgacatttga actgccagcc tcagttgtca     1447
 Lys Glu Ser His Ser 
     305

 cgtggactct tgatgcccaa ttattgcctc aatccagaaa agtttacttc tctttatctg   1507

 tgctttactg acagaagggc aagtcttctc tcgttttttg cagataaaat tttagatgtg   1567

 ttgcattcat tgggtttcta tgagatgtgg ttttatcaga caattttttc ttttatttca   1627

 caattacttt aatatctgta aaataaagaa ttattttaat tcattttccc agtcccaaaa   1687

 gttaaataca ggccacttac ttctttaacc aaatgatata gtttggctct gtgtccccac   1747

 ccaaatctca tgtcaaattg taatccccgc atgtg                              1782




      <210> 461
      <211> 984
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (243)..(569)

      <400> 461
 acctgacgcc tctctagtcc agcgtggtgg aattccatcc ccttccccac cctgaaaaga     60

 attttactgg ctgctaagtc tattacctta tttttcctga tctttaactt aactgcttta    120

 gagcatctct ggacgtctgg attcttaatt gtctttattt ctgacccttc atttttaatc    180

 tttcatttgt taaattttta aactgtgctg cactaaaatg tgtgtggtac tacttaacac    240

 tt   atg atc gtg atg gca ttt tcc ctg aaa gcc atc ttc ctc ctg ttt     287
      Met Ile Val Met Ala Phe Ser Leu Lys Ala Ile Phe Leu Leu Phe
        1               5                  10                  15

 ccc ttg aaa tcc cat cct gct ttt cct gta cac tac ccc tca caa acc      335
 Pro Leu Lys Ser His Pro Ala Phe Pro Val His Tyr Pro Ser Gln Thr
                  20                  25                  30

 aca agc tgc agc aac atg gat gcc cag cct gga gca gca gca gcc agg      383
 Thr Ser Cys Ser Asn Met Asp Ala Gln Pro Gly Ala Ala Ala Ala Arg
              35                  40                  45

 atg acc tgg agc cag ggg ggc ctt cgg aac aga tgc aca ccc ttc ctg      431
 Met Thr Trp Ser Gln Gly Gly Leu Arg Asn Arg Cys Thr Pro Phe Leu
          50                  55                  60

 ggt gat gtt ttc ggc ttt gtg aga aac ctt acc atc aaa cac gat ggc      479
 Gly Asp Val Phe Gly Phe Val Arg Asn Leu Thr Ile Lys His Asp Gly
      65                  70                  75

 cag caa cgt tac caa caa gac aga tcc tcg ctc cat gaa ctc ccg tgt      527
 Gln Gln Arg Tyr Gln Gln Asp Arg Ser Ser Leu His Glu Leu Pro Cys
  80                  85                  90                  95

 att cat tgg gaa tct caa cac tct tgt ggt caa gaa atc tga tgtggag      576
 Ile His Trp Glu Ser Gln His Ser Cys Gly Gln Glu Ile 
                 100                 105

 gcaatctttt cgaagtatgg caaaattgtg ggctgctctg ttcataaggg ctttgccttc    636

 gttcagtatg ttaatgagag aaatgcccgg gctgctgtag caggagagga tggcacgaat    696

 gattgctggc caggttttag atattaacct ggctgcagag ccaaaagtga accgaggaaa    756

 agcaggtgtg aaacgatctg cagcggagat gtacggcttc ctcttttgac ttggactatg    816

 actttcaacg ggacttacta tgatagcgca tgtacagtta cccagcacgt gtacctccct    876

 cttcctccta ttgctcgggc tgtagtgcct cgaaaagtca gcgtgtatca ggaaacactt    936

 cacgaagggc aaaagtggtt caattctaca gtggccgcgg ggatctac                 984




      <210> 462
      <211> 1566
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (244)..(1008)

      <400> 462
 agtttggagt gcctactagt tagttcctct gacctgaaga taacattctg ctactagtga     60

 ttttttgccc agtgattgtt gaagttttca taaatctcgt tgatagaatg ttctattgtt    120

 acaacgtggg caagcatctg tgcatatgaa atgctgtttt tctaaaagat ttctcacatt    180

 ggcaaactga gagattttct tctggaacac aggaaagatt atattaatgc ttatagccat    240

 acc  atg tct gaa tat ggg agg atg aca gac aca gaa cga gac cag ata     288
      Met Ser Glu Tyr Gly Arg Met Thr Asp Thr Glu Arg Asp Gln Ile
        1               5                  10                  15

 gac cag gat gcc cag ata ttc atg agg acc tgt tca gaa gca att cag      336
 Asp Gln Asp Ala Gln Ile Phe Met Arg Thr Cys Ser Glu Ala Ile Gln
                  20                  25                  30

 caa cta cga aca gaa gct cac aag gag ata cat tcc cag caa gtg aag      384
 Gln Leu Arg Thr Glu Ala His Lys Glu Ile His Ser Gln Gln Val Lys
              35                  40                  45

 gag cac agg acc gct gtt ttg gat ttc att gaa gat tac ttg aaa aga      432
 Glu His Arg Thr Ala Val Leu Asp Phe Ile Glu Asp Tyr Leu Lys Arg
          50                  55                  60

 gta tgt aaa ctt tac tca gaa cag aga gcc atc cga gtt aaa aga gtg      480
 Val Cys Lys Leu Tyr Ser Glu Gln Arg Ala Ile Arg Val Lys Arg Val
      65                  70                  75

 gtg gat aag aaa aga tta tct aag ctg gaa cca gaa cca aat aca aag      528
 Val Asp Lys Lys Arg Leu Ser Lys Leu Glu Pro Glu Pro Asn Thr Lys
  80                  85                  90                  95

 aca aga gaa tcc aca tct tct gag aaa gtt tca cag agt cct tca aaa      576
 Thr Arg Glu Ser Thr Ser Ser Glu Lys Val Ser Gln Ser Pro Ser Lys
                 100                 105                 110

 gac tct gaa gaa aac cct gcc act gaa gaa cgt cca gaa aaa att ttg      624
 Asp Ser Glu Glu Asn Pro Ala Thr Glu Glu Arg Pro Glu Lys Ile Leu
             115                 120                 125

 gct gaa aca caa cct gaa ttg gga acg tgg gga gat ggc aaa ggc gaa      672
 Ala Glu Thr Gln Pro Glu Leu Gly Thr Trp Gly Asp Gly Lys Gly Glu
         130                 135                 140

 gat gag tta tcc cca gaa gaa ata caa atg ttt gaa cag gaa aat cag      720
 Asp Glu Leu Ser Pro Glu Glu Ile Gln Met Phe Glu Gln Glu Asn Gln
     145                 150                 155

 cga cta att ggt gaa atg aac agc ttg ttt gat gaa gtg agg caa atc      768
 Arg Leu Ile Gly Glu Met Asn Ser Leu Phe Asp Glu Val Arg Gln Ile
 160                 165                 170                 175

 gaa ggg aga gtg gtt gag att tcc aga ctc caa gag ata ttc acg gaa      816
 Glu Gly Arg Val Val Glu Ile Ser Arg Leu Gln Glu Ile Phe Thr Glu
                 180                 185                 190

 aag gtt ttg caa cag gaa gct gag att gac agc att cac cag tta gtt      864
 Lys Val Leu Gln Gln Glu Ala Glu Ile Asp Ser Ile His Gln Leu Val
             195                 200                 205

 gtg ggg gca act gaa aat atc aag gaa ggc aac gaa gac ata aga gag      912
 Val Gly Ala Thr Glu Asn Ile Lys Glu Gly Asn Glu Asp Ile Arg Glu
         210                 215                 220

 gcc att aaa aac aac gct ggc ttc cgc gtg tgg atc ctc ttc ttc ctc      960
 Ala Ile Lys Asn Asn Ala Gly Phe Arg Val Trp Ile Leu Phe Phe Leu
     225                 230                 235

 gtg atg tgc tcc ttc tcc ttg ctc ttc ctc gac tgg tac gac agc tag     1008
 Val Met Cys Ser Phe Ser Leu Leu Phe Leu Asp Trp Tyr Asp Ser 
 240                 245                 250

 ccagggccac gggggcccag cacgagagtc ctcatgggca ctcacagact gcgtgctttc   1068

 atgtacttcc agtgctggag catggtatga ccagatttta tcacagtgcc atttgaaggg   1128

 aaaggagttc agacagacag acgtattccc caaaaaggga taccccaggc cgatggtgtt   1188

 cagccattta gcagctgaaa aaggaaacag tgcacaccaa tgggaggcag cctgcgtagc   1248

 cctcatcagg caagacagac tgaatgcagg agtgggtgat tagctgctcc ttgaacttga   1308

 ggctgccttg gcagcagggg cacagcaggc ctcaagagcc cctaattgtc tcagggttca   1368

 aaggaagaca ctgacctttc ccatcccggt agcttcaggg aagatcatag ttaataacgt   1428

 ctctcaacaa atgattactt ctttgtttcc ttgtggcttc ttgtctgtct gagtcaacga   1488

 atacacagac ttactggatt atagaagaga aaattcacat ctgccttgtt aatctaataa   1548

 atataattac agcccctt                                                 1566




      <210> 463
      <211> 1199
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (63)..(521)

      <400> 463
 agggatcagg gttccaggaa ctcaggatct gcagtgagga ccagacacca ctgattgcag     60

 ga   atg tgt tcc ctc ccc atg gca aga tac tac ata att aaa tat gca     107
      Met Cys Ser Leu Pro Met Ala Arg Tyr Tyr Ile Ile Lys Tyr Ala
        1               5                  10                  15

 gac cag aag gct cta tac aca aga gat ggc cag ctg ctg gtg gga gat      155
 Asp Gln Lys Ala Leu Tyr Thr Arg Asp Gly Gln Leu Leu Val Gly Asp
                  20                  25                  30

 cct gtt gca gac aac tgc tgt gca gag aag atc tgc ata ctt cct aac      203
 Pro Val Ala Asp Asn Cys Cys Ala Glu Lys Ile Cys Ile Leu Pro Asn
              35                  40                  45

 aga ggc ttg gac cgc acc aag gtc ccc att ttc ctg ggg atc cag gga      251
 Arg Gly Leu Asp Arg Thr Lys Val Pro Ile Phe Leu Gly Ile Gln Gly
          50                  55                  60

 ggg agc cgc tgc ctg gca tgt gtg gag aca gaa gag ggg cct tcc cta      299
 Gly Ser Arg Cys Leu Ala Cys Val Glu Thr Glu Glu Gly Pro Ser Leu
      65                  70                  75

 cag ctg gag gat gtg aac att gag gaa ctg tac aaa ggt ggt gaa gag      347
 Gln Leu Glu Asp Val Asn Ile Glu Glu Leu Tyr Lys Gly Gly Glu Glu
  80                  85                  90                  95

 gcc aca cgc ttc acc ttc ttc cag agc agc tca ggc tcc gcc ttc agg      395
 Ala Thr Arg Phe Thr Phe Phe Gln Ser Ser Ser Gly Ser Ala Phe Arg
                 100                 105                 110

 ctt gag gct gct gcc tgg cct ggc tgg ttc ctg tgt ggc ccg gca gag      443
 Leu Glu Ala Ala Ala Trp Pro Gly Trp Phe Leu Cys Gly Pro Ala Glu
             115                 120                 125

 ccc cag cag cca gta cag ctc acc aag gag agt gag ccc tca gcc cgt      491
 Pro Gln Gln Pro Val Gln Leu Thr Lys Glu Ser Glu Pro Ser Ala Arg
         130                 135                 140

 acc aag ttt tac ttt gaa cag agc tgg tag g gagacaggaa actgcgtttt      542
 Thr Lys Phe Tyr Phe Glu Gln Ser Trp 
     145                 150

 agccttgtgc ccccaaacca agctcatcct gctcagggtc tatggtaggc agaataatgt    602

 cccccgaaat atgtccacat cctaatccca agatctgtgc atatgttacc atacatgtcc    662

 aaagaggttt tgcaaatgtg attatgttaa ggatcttgaa atgaggagac aatcctgggt    722

 tatccttgtg ggctcagttt aatcacaaga aggaggcagg aagggagagt cagagagaga    782

 atggaagata ccatgcttct aattttgaag atggagtgag gggccttgag ccaacaaatg    842

 caggtgtttt tagaaggtgg aaaagccaag ggaacggatt ctcctctaga gtctccggaa    902

 ggaacacagc tcttgacaca tggatttcag ctcagtgaca cccatttcag acttctgacc    962

 tccacaacta taaaataata aacttgtgtt attgtaaacc tctaaaaaaa aaaaaaaaaa   1022

 aaaaaaaaaa aaaaaaaggg ggggggcctt tttaaggaac caatttttat tcccgggggg   1082

 ggggaaagtt tttttttttt tttggggccc caaaatttaa tttcgggggg gggtttttaa   1142

 aacggggggg ggggaaaaac ccggggggta cccaatttaa aggcttgggg agaaaaa      1199




      <210> 464
      <211> 1524
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1524)

      <400> 464
  atg cag ttc ctg aat gac aga ctc gcc agc tat ctg gag aag gtg cgc      48
  Met Gln Phe Leu Asn Asp Arg Leu Ala Ser Tyr Leu Glu Lys Val Arg
    1               5                  10                  15

 agc ctg gag gag acc aac gca gag ctg gaa tcc agg atc caa gaa caa       96
 Ser Leu Glu Glu Thr Asn Ala Glu Leu Glu Ser Arg Ile Gln Glu Gln
              20                  25                  30

 tgt gaa cag gat atc cca atg gtg tgc ccg gat tat cag cgt tac ttc      144
 Cys Glu Gln Asp Ile Pro Met Val Cys Pro Asp Tyr Gln Arg Tyr Phe
          35                  40                  45

 aac acc att gaa gat ctc caa caa aag atc tta tgc acg aaa gca gag      192
 Asn Thr Ile Glu Asp Leu Gln Gln Lys Ile Leu Cys Thr Lys Ala Glu
      50                  55                  60

 aat tct aga ctt gct gta cag ctt gac aac tgc aaa ctg gcc act gat      240
 Asn Ser Arg Leu Ala Val Gln Leu Asp Asn Cys Lys Leu Ala Thr Asp
  65                  70                  75                  80

 gac ttt aag tca aag tac gag agt gaa ctg tcc ctt cgc cag ctg tta      288
 Asp Phe Lys Ser Lys Tyr Glu Ser Glu Leu Ser Leu Arg Gln Leu Leu
                  85                  90                  95

 gag gct gac atc agc agc ctg cat ggg atc ctg gag gaa ctg acc ctg      336
 Glu Ala Asp Ile Ser Ser Leu His Gly Ile Leu Glu Glu Leu Thr Leu
             100                 105                 110

 tgc aaa tct gat ctg gag gcc cat gtg gag tct ctg aag gaa gat ctc      384
 Cys Lys Ser Asp Leu Glu Ala His Val Glu Ser Leu Lys Glu Asp Leu
         115                 120                 125

 ctt tgc ctt aag aaa aac cat gaa gag gaa gtc aac ttg ctt cgt gaa      432
 Leu Cys Leu Lys Lys Asn His Glu Glu Glu Val Asn Leu Leu Arg Glu
     130                 135                 140

 cag ctt ggc gac cgc ctc agt gtg gag ctg gac act gcc ccc acc ctt      480
 Gln Leu Gly Asp Arg Leu Ser Val Glu Leu Asp Thr Ala Pro Thr Leu
 145                 150                 155                 160

 gac ctc aac agg gtc ctg gat gag atg cgc tgt cag tgt gaa acg gtg      528
 Asp Leu Asn Arg Val Leu Asp Glu Met Arg Cys Gln Cys Glu Thr Val
                 165                 170                 175

 ctt gcc aac aat cgc aga gaa gct gaa gaa tgg ttg gct gtt cag aca      576
 Leu Ala Asn Asn Arg Arg Glu Ala Glu Glu Trp Leu Ala Val Gln Thr
             180                 185                 190

 gaa gag ctg aat cag cag caa ctg tcc agc gcg gag cag ctg cag ggc      624
 Glu Glu Leu Asn Gln Gln Gln Leu Ser Ser Ala Glu Gln Leu Gln Gly
         195                 200                 205

 tgc cag atg gag atc ttg gaa ctg aaa cgc aca gcc agt gct ctg gaa      672
 Cys Gln Met Glu Ile Leu Glu Leu Lys Arg Thr Ala Ser Ala Leu Glu
     210                 215                 220

 att gag ctc caa gca cag caa agc ctg aca gaa tct ctg gaa tgc acc      720
 Ile Glu Leu Gln Ala Gln Gln Ser Leu Thr Glu Ser Leu Glu Cys Thr
 225                 230                 235                 240

 gtg gca gaa acc gag gcc cag tac agc tcc cag ctg gcc caa att cag      768
 Val Ala Glu Thr Glu Ala Gln Tyr Ser Ser Gln Leu Ala Gln Ile Gln
                 245                 250                 255

 tgt ctg atc gat aac ctg gag aac cag ctg gcc gag atc cgc tgc gac      816
 Cys Leu Ile Asp Asn Leu Glu Asn Gln Leu Ala Glu Ile Arg Cys Asp
             260                 265                 270

 ctg gag cga cag aac cag gag tac cag gtg ctc ctg gac gtg aag gcc      864
 Leu Glu Arg Gln Asn Gln Glu Tyr Gln Val Leu Leu Asp Val Lys Ala
         275                 280                 285

 cgg ctg gag ggt gag atc aac acc agt acc aag gcc acc ccc atg cag      912
 Arg Leu Glu Gly Glu Ile Asn Thr Ser Thr Lys Ala Thr Pro Met Gln
     290                 295                 300

 tgt cag tgg aag ctg cat ggg agc aat aac aag ata ttc ctg ccc ctc      960
 Cys Gln Trp Lys Leu His Gly Ser Asn Asn Lys Ile Phe Leu Pro Leu
 305                 310                 315                 320

 ctg gcc agg gtg gta tca gca gag gcc agg ttt ggt aat gaa aag aag     1008
 Leu Ala Arg Val Val Ser Ala Glu Ala Arg Phe Gly Asn Glu Lys Lys
                 325                 330                 335

 gca gaa gcc acc ttc atg gaa gaa gtg cct cat ggt tac ggg tca gac     1056
 Ala Glu Ala Thr Phe Met Glu Glu Val Pro His Gly Tyr Gly Ser Asp
             340                 345                 350

 att ccc atc tac cta atg aac aac ttc aat gcc cgt ttt tct ctg gat     1104
 Ile Pro Ile Tyr Leu Met Asn Asn Phe Asn Ala Arg Phe Ser Leu Asp
         355                 360                 365

 gac tgc agc tgg tat ggt gaa ggc atc aac agt aat gag aag gag acc     1152
 Asp Cys Ser Trp Tyr Gly Glu Gly Ile Asn Ser Asn Glu Lys Glu Thr
     370                 375                 380

 atg caa atc ttg aac gag cgc ctt gct aac tac ctg caa aag gtg cga     1200
 Met Gln Ile Leu Asn Glu Arg Leu Ala Asn Tyr Leu Gln Lys Val Arg
 385                 390                 395                 400

 atg cta gaa cga gag aat gct gaa ctg gaa tct aaa atc cag gaa gaa     1248
 Met Leu Glu Arg Glu Asn Ala Glu Leu Glu Ser Lys Ile Gln Glu Glu
                 405                 410                 415

 agt aac aaa gag ctc cct gtt cta tgt cct gat tac ctg tct tac tac     1296
 Ser Asn Lys Glu Leu Pro Val Leu Cys Pro Asp Tyr Leu Ser Tyr Tyr
             420                 425                 430

 act acc att gag gag ctc cag cag aag atc ttg tgt acc aag gcc gag     1344
 Thr Thr Ile Glu Glu Leu Gln Gln Lys Ile Leu Cys Thr Lys Ala Glu
         435                 440                 445

 aat tcc aga ctg gtc tcg caa att gac aac acc aaa ctg act gca gat     1392
 Asn Ser Arg Leu Val Ser Gln Ile Asp Asn Thr Lys Leu Thr Ala Asp
     450                 455                 460

 gac ttg aga gcc aaa gct cac cct gag tct gac cga gat gcc ctc aac     1440
 Asp Leu Arg Ala Lys Ala His Pro Glu Ser Asp Arg Asp Ala Leu Asn
 465                 470                 475                 480

 aaa att gtc ccc atg tct act aac cct ctt gcc cca gat gat gtt ggc     1488
 Lys Ile Val Pro Met Ser Thr Asn Pro Leu Ala Pro Asp Asp Val Gly
                 485                 490                 495

 aca agc cca gaa aag act ttc aaa ttc aat gaa tga                     1524
 Thr Ser Pro Glu Lys Thr Phe Lys Phe Asn Glu 
             500                 505





      <210> 465
      <211> 1247
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (102)..(1061)

      <400> 465
 actcgcgtcc ctgcgccgtg cctgcctcgc gctccctgtt acggcgttcg tccccgggcc     60

 tggcgcccgc gtccggcccg gctccgcggc ggcctggtcc g    atg gct cct cag     113
                                                  Met Ala Pro Gln
                                                    1

 cgg agg gcc gca acc aag gcg ccc gag ggc aac gga gcg gcc gag cgc      161
 Arg Arg Ala Ala Thr Lys Ala Pro Glu Gly Asn Gly Ala Ala Glu Arg
   5                  10                  15                  20

 cgg aac cgg agc agc acc aag aag gac cga gcc ccg cgg gag gtg cag      209
 Arg Asn Arg Ser Ser Thr Lys Lys Asp Arg Ala Pro Arg Glu Val Gln
                  25                  30                  35

 agg ctg tgg cag agg ccg tgg cta agg acc gcg ggc ctg ggg gct ggc      257
 Arg Leu Trp Gln Arg Pro Trp Leu Arg Thr Ala Gly Leu Gly Ala Gly
              40                  45                  50

 ttt gtg ctc acc gca ctc ctg ctc tgg agc agc ttg ggg gcc gac gac      305
 Phe Val Leu Thr Ala Leu Leu Leu Trp Ser Ser Leu Gly Ala Asp Asp
          55                  60                  65

 ggg gtc gca gag gtc ctg gcc cgc cgt ggc gag gtc gtg gca ggg aga      353
 Gly Val Ala Glu Val Leu Ala Arg Arg Gly Glu Val Val Ala Gly Arg
      70                  75                  80

 ttc atc gag gtg ccc tgc tct gag gac tac gac agt cac cgc agg ttc      401
 Phe Ile Glu Val Pro Cys Ser Glu Asp Tyr Asp Ser His Arg Arg Phe
  85                  90                  95                 100

 gaa ggc tgc act ccc cga aag tgc ggc aga ggt gtc acc gat gtc gtc      449
 Glu Gly Cys Thr Pro Arg Lys Cys Gly Arg Gly Val Thr Asp Val Val
                 105                 110                 115

 atc acc agg gag gaa gcg gag cgg att cgc agc gta gct gaa aag ggg      497
 Ile Thr Arg Glu Glu Ala Glu Arg Ile Arg Ser Val Ala Glu Lys Gly
             120                 125                 130

 ctc tcc ctg gga gga tct gac gga ggg gca tcc att ctg gac ttg cac      545
 Leu Ser Leu Gly Gly Ser Asp Gly Gly Ala Ser Ile Leu Asp Leu His
         135                 140                 145

 tca ggg gcc ctg tct gtc ggg aag cac ttt gtg aac ctg tac aga tac      593
 Ser Gly Ala Leu Ser Val Gly Lys His Phe Val Asn Leu Tyr Arg Tyr
     150                 155                 160

 ttc ggg gat aaa ata cag aac atc ttc tca gag gag gac ttc cgg tta      641
 Phe Gly Asp Lys Ile Gln Asn Ile Phe Ser Glu Glu Asp Phe Arg Leu
 165                 170                 175                 180

 tac cgg gag gtg cgg cag aag gtc cag ctc acc att gct gag gct ttt      689
 Tyr Arg Glu Val Arg Gln Lys Val Gln Leu Thr Ile Ala Glu Ala Phe
                 185                 190                 195

 ggc atc agc gca tcc tcg ctg cat ctg acc aag ccc acc ttc ttc tcc      737
 Gly Ile Ser Ala Ser Ser Leu His Leu Thr Lys Pro Thr Phe Phe Ser
             200                 205                 210

 cgc ata aac agc acg gaa gcg cgg acg gcg cac gac gag tac tgg cat      785
 Arg Ile Asn Ser Thr Glu Ala Arg Thr Ala His Asp Glu Tyr Trp His
         215                 220                 225

 gcg cac gtg gac aag gtg acc tac ggc tcc ttc gac tac acc tcg ctg      833
 Ala His Val Asp Lys Val Thr Tyr Gly Ser Phe Asp Tyr Thr Ser Leu
     230                 235                 240

 ctg tac ctc tcc aac tac ctg gag gac ttc ggc gga ggg cgg ttc atg      881
 Leu Tyr Leu Ser Asn Tyr Leu Glu Asp Phe Gly Gly Gly Arg Phe Met
 245                 250                 255                 260

 ttc atg gag gag ggt gcc aac aag acg gtg gag ccg aga gct ggt cgc      929
 Phe Met Glu Glu Gly Ala Asn Lys Thr Val Glu Pro Arg Ala Gly Arg
                 265                 270                 275

 gtc tcc ttc ttc acc tcg ggg tcc gag aac cta cac cgc gtg gag aag      977
 Val Ser Phe Phe Thr Ser Gly Ser Glu Asn Leu His Arg Val Glu Lys
             280                 285                 290

 gtc cac tgg ggc acc cgt tac gcc atc acc atc gcc ttc agc tgc aac     1025
 Val His Trp Gly Thr Arg Tyr Ala Ile Thr Ile Ala Phe Ser Cys Asn
         295                 300                 305

 ccc gac cat ggc atc gag gac cca gcg ttc ccg tag ccag cagccgggcc     1075
 Pro Asp His Gly Ile Glu Asp Pro Ala Phe Pro 
     310                 315

 aaggtaactt caggagggcc cgtgtggagg cagccgcgcc agtcgtgcac ccacccccac   1135

 gtccacccgc tcctgttgca cagagtgcct taggaattct ctgattttga tttgctgacg   1195

 tgttaatctt ttcatctgtg agtaaatgaa gggaaccagc aaaaaaaaaa aa           1247




      <210> 466
      <211> 2550
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (482)..(1450)

      <400> 466
 gttctcgact attgccgaag tgagccgaag tttgtggccc cgcttccgga gaactcaagc     60

 tcccgattgt gcccgaagga acccgaaggg agaccccgcc tcattcctca cgccgagctc    120

 cagaccccgc ctcctttcca gagcccgtct gttccccttc gggtccaaag cttttggctc    180

 ctccttgttc cgagcccgaa ggcccgcccc ttcacgtact cggagctcgg atcccagtgt    240

 ggacctggac tcgaatcccg ttgccgactc gcgctctcgg cttctgctcc ggggcttctt    300

 ccctgcccgc ccggggccct gaccgtggct tcttccccgg cctgatctgc gcagcccggc    360

 gggcgcccag aaggagcagg cggcgcgggg gcgcgctggg cgggggaggc gtggccggag    420

 ctgcggcggc aagcgggctg ggactgctcg gccgcctcct gcccggcgag cagctcagac    480

 c    atg tcg cct gaa gaa tgg acg tat cta gtg gtt ctt ctt atc tcc     526
      Met Ser Pro Glu Glu Trp Thr Tyr Leu Val Val Leu Leu Ile Ser
        1               5                  10                  15

 atc ccc atc ggc ttc ctc ttt aag aaa gcc ggt cct ggg ctg aag aga      574
 Ile Pro Ile Gly Phe Leu Phe Lys Lys Ala Gly Pro Gly Leu Lys Arg
                  20                  25                  30

 tgg gga gca gcc gct gtg ggc ctg ggg ctc acc ctg ttc acc tgt ggc      622
 Trp Gly Ala Ala Ala Val Gly Leu Gly Leu Thr Leu Phe Thr Cys Gly
              35                  40                  45

 ccc cac act ttg cat tct ctg gtc acc atc ctc ggg acc tgg gcc ctc      670
 Pro His Thr Leu His Ser Leu Val Thr Ile Leu Gly Thr Trp Ala Leu
          50                  55                  60

 att cag gcc cag ccc tgc ccc tgc cac gcc ctg gct ctg gcc tgg act      718
 Ile Gln Ala Gln Pro Cys Pro Cys His Ala Leu Ala Leu Ala Trp Thr
      65                  70                  75

 ttc tcc tat ctc ctg ttc ttc cga gcc ctc agc ctc ctg ggc ctg ccc      766
 Phe Ser Tyr Leu Leu Phe Phe Arg Ala Leu Ser Leu Leu Gly Leu Pro
  80                  85                  90                  95

 act ccc acg ccc ttc acc aat gcc gtc cag ctg ctg ctg acg ctg aag      814
 Thr Pro Thr Pro Phe Thr Asn Ala Val Gln Leu Leu Leu Thr Leu Lys
                 100                 105                 110

 ctg gtg agc ctg gcc agt gaa gtc cag gac ctg cat ctg gcc cag agg      862
 Leu Val Ser Leu Ala Ser Glu Val Gln Asp Leu His Leu Ala Gln Arg
             115                 120                 125

 aag gaa atg gcc tca ggc ttc agc aag ggg ccc acc ctg ggg ctg ctg      910
 Lys Glu Met Ala Ser Gly Phe Ser Lys Gly Pro Thr Leu Gly Leu Leu
         130                 135                 140

 ccc gac gtg ccc tcc ctg atg gag aca ctc agc tac agc tac tgc tac      958
 Pro Asp Val Pro Ser Leu Met Glu Thr Leu Ser Tyr Ser Tyr Cys Tyr
     145                 150                 155

 gtg gga atc atg aca ggc ccg ttc ttc cgc tac cgc acc tac ctg gac     1006
 Val Gly Ile Met Thr Gly Pro Phe Phe Arg Tyr Arg Thr Tyr Leu Asp
 160                 165                 170                 175

 tgg ctg gag cag ccc ttc ccc ggg gca gtg ccc agc ctg cgg ccc ctg     1054
 Trp Leu Glu Gln Pro Phe Pro Gly Ala Val Pro Ser Leu Arg Pro Leu
                 180                 185                 190

 ctg cgc cgc gcc tgg ccg gcc ccg ctc ttc ggc ctg ctg ttc ctg ctc     1102
 Leu Arg Arg Ala Trp Pro Ala Pro Leu Phe Gly Leu Leu Phe Leu Leu
             195                 200                 205

 tcc tct cac ctc ttc ccg ctg gag gcc gtg cgc gag gac gcc ttc tac     1150
 Ser Ser His Leu Phe Pro Leu Glu Ala Val Arg Glu Asp Ala Phe Tyr
         210                 215                 220

 gcc cgc ccg ctg ccc gcc cgc ctc ttc tac atg atc ccc gtc ttc ttc     1198
 Ala Arg Pro Leu Pro Ala Arg Leu Phe Tyr Met Ile Pro Val Phe Phe
     225                 230                 235

 gcc ttc cgc atg cgc ttc tac gtg gcc tgg att gcc gcc gca ctg cgg     1246
 Ala Phe Arg Met Arg Phe Tyr Val Ala Trp Ile Ala Ala Ala Leu Arg
 240                 245                 250                 255

 ccc gca ttg ccg ccg gct ttg ggg cct acc ccg tgg ccg cca aag ccc     1294
 Pro Ala Leu Pro Pro Ala Leu Gly Pro Thr Pro Trp Pro Pro Lys Pro
                 260                 265                 270

 ggg ccg gag gcg gcc cca ccc tcc aat gcc cac ccc cca gca gtc cgg     1342
 Gly Pro Glu Ala Ala Pro Pro Ser Asn Ala His Pro Pro Ala Val Arg
             275                 280                 285

 aga agg cgg ctt cct tgg agt atg act atg aga cca tcc gca aca tcg     1390
 Arg Arg Arg Leu Pro Trp Ser Met Thr Met Arg Pro Ser Ala Thr Ser
         290                 295                 300

 act gct aca gca cag att tct gcg tgc ggg tgc gcg atg gca tgc ggt     1438
 Thr Ala Thr Ala Gln Ile Ser Ala Cys Gly Cys Ala Met Ala Cys Gly
     305                 310                 315

 act gga aca tga cgg tgcagtggtg gctggcgcag tatatctaca agaggcgcaa     1493
 Thr Gly Thr 
 320

 cctgcccgtt cctatgtcct gcggagcgcc tggaccatgc tgctgaggcg cctactggca   1553

 cggcctccac ccgggctact acctgagctt cctgaccatc ccgctgtgcc tggctgccga   1613

 gggccggctg gagtcagccc tgcgggggcg gctgagccca gggggccaga aggcctggga   1673

 ctgggtgcac tggttcctga agatgcgcgc ctatgactac atgtgcatgg gcttcgtgct   1733

 gctctccttg gccgacaccc ttcggtactg ggcctccatc tacttctgta tccacttcct   1793

 ggccctggca gccctggggc tggggctggc tttaggtggg ggcagcccca gccggcggaa   1853

 ggcagcatcc cagcccacca gccttgcccc ggagaagctc cgggaggagt aagctgtcac   1913

 gacgctccct ctgccagctg gtcccgggaa ttctgtgaac caggctgctg tctcctcccc   1973

 agaaagagtc cttaccttgg agagggtcct ggagagaatt tcctcttccc cagctaaata   2033

 ccctgcctgc aactgaagca gacccggggg tgtcctccct gccctctgcc cagaggccac   2093

 ctccactcct acaaaatcaa agtattgtcc agacaagagt cactggcccc tgctccagct   2153

 tctgggtatc cagagagcac tgcacttccc caaaacggaa ggggcccctg ggcagtgggt   2213

 tttgggcaaa ttccctttct ttgcatccac aatgtggggt cggagcttgg gggcaggtcc   2273

 tgggagtggg aagcctcttc cttgtgtctt tcgctccact tttagctcat cgcaccaata   2333

 ttgcagactt ggaaggaagc ataagcttcc catttcacaa aggggaaact gaggtgcggg   2393

 tgcgcgggcc tggggacggc cgtcccatgg cttccatctg agccacctcg ggaccccagc   2453

 gctcctggcg ccctcttctc atcgcttggc ctatgacagg tcaccgtgtg taaatctttc   2513

 ccaataaagt gttgcacaaa ggaaaaaaaa aaaaaaa                            2550




      <210> 467
      <211> 1643
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(1561)

      <400> 467
 cagcatctta tccccacttt ctggcctccc cacc    atg agc cgc caa ttc acc      52
                                          Met Ser Arg Gln Phe Thr
                                            1               5

 tac aag tcg gga gct gct gcc aag ggg ggc ttc agc ggc tgc tcc gct      100
 Tyr Lys Ser Gly Ala Ala Ala Lys Gly Gly Phe Ser Gly Cys Ser Ala
              10                  15                  20

 gtg ctc tca ggg ggc agc tca tcc tcc tac cga gca ggg ggc aaa ggg      148
 Val Leu Ser Gly Gly Ser Ser Ser Ser Tyr Arg Ala Gly Gly Lys Gly
          25                  30                  35

 ctc agt gga ggc ttc agc agt cgg agc ctt tac agc ctg ggg ggt gcc      196
 Leu Ser Gly Gly Phe Ser Ser Arg Ser Leu Tyr Ser Leu Gly Gly Ala
      40                  45                  50

 cgg agc atc tct ttc aat gtg gcc agt ggc agt ggg tgg gca gga ggc      244
 Arg Ser Ile Ser Phe Asn Val Ala Ser Gly Ser Gly Trp Ala Gly Gly
  55                  60                  65                  70

 tat gga ttt ggc cgg ggc cgg gcc agt ggc ttt gct ggc agc atg ttt      292
 Tyr Gly Phe Gly Arg Gly Arg Ala Ser Gly Phe Ala Gly Ser Met Phe
                  75                  80                  85

 ggc agt gtg gcc ttg ggg tcc gtg tgt ccg tcg ttg tgc ccg ccc ggg      340
 Gly Ser Val Ala Leu Gly Ser Val Cys Pro Ser Leu Cys Pro Pro Gly
              90                  95                 100

 ggt atc cat cag gtc acc atc aac aag agc ctc ctg gca ccc ctg aat      388
 Gly Ile His Gln Val Thr Ile Asn Lys Ser Leu Leu Ala Pro Leu Asn
         105                 110                 115

 gtg gag ctg gac cct gaa atc cag aaa gtg cgt gcc cag gag cgg gag      436
 Val Glu Leu Asp Pro Glu Ile Gln Lys Val Arg Ala Gln Glu Arg Glu
     120                 125                 130

 cag atc aag gtg ctg aac aac aag ttc gcc tcc ttc att gac aag gtg      484
 Gln Ile Lys Val Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val
 135                 140                 145                 150

 cgg ttc ctg gag cag cag aac cag gtg ctg gag acc aag tgg gag ctg      532
 Arg Phe Leu Glu Gln Gln Asn Gln Val Leu Glu Thr Lys Trp Glu Leu
                 155                 160                 165

 cta cag cag ctg gac ctg aac aac tgc aag aat aac ctg gag ccc atc      580
 Leu Gln Gln Leu Asp Leu Asn Asn Cys Lys Asn Asn Leu Glu Pro Ile
             170                 175                 180

 ctt gag ggc tac atc agc aac ctg cgg aag cag ctg gag acg ctg tct      628
 Leu Glu Gly Tyr Ile Ser Asn Leu Arg Lys Gln Leu Glu Thr Leu Ser
         185                 190                 195

 ggg gac agg gtg agg ctg gac tcg gag ctg agg agc gtg cgc gaa gtg      676
 Gly Asp Arg Val Arg Leu Asp Ser Glu Leu Arg Ser Val Arg Glu Val
     200                 205                 210

 gtg gag gac tac aag aag agg tat gaa gaa gaa ata aac aag cgc aca      724
 Val Glu Asp Tyr Lys Lys Arg Tyr Glu Glu Glu Ile Asn Lys Arg Thr
 215                 220                 225                 230

 act gct gag aat gaa ttt gtg gtg ctt aag aag gag act gct cag atc      772
 Thr Ala Glu Asn Glu Phe Val Val Leu Lys Lys Glu Thr Ala Gln Ile
                 235                 240                 245

 cag tcc cac atc agc gac acg tcc atc atc ctg tcc atg gac aac aac      820
 Gln Ser His Ile Ser Asp Thr Ser Ile Ile Leu Ser Met Asp Asn Asn
             250                 255                 260

 cgg aac ctg gac ctg gac agc atc att gct gag gtc cgt gcc cag tat      868
 Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu Val Arg Ala Gln Tyr
         265                 270                 275

 gag gag atc gcc cgg aag agc aag gcc gag gcc gag gcc ctg tac cag      916
 Glu Glu Ile Ala Arg Lys Ser Lys Ala Glu Ala Glu Ala Leu Tyr Gln
     280                 285                 290

 acc aag ttc cag gag ctg cag cta gca gcc ggc cgg cat ggg gat gac      964
 Thr Lys Phe Gln Glu Leu Gln Leu Ala Ala Gly Arg His Gly Asp Asp
 295                 300                 305                 310

 ctg aaa cac acc aaa aat gag atc tca gag ctg acc cgt ctc atc caa     1012
 Leu Lys His Thr Lys Asn Glu Ile Ser Glu Leu Thr Arg Leu Ile Gln
                 315                 320                 325

 aga ctg cgc tcg gag att gag agt gtg aag aag cag tgt gcc aac ctg     1060
 Arg Leu Arg Ser Glu Ile Glu Ser Val Lys Lys Gln Cys Ala Asn Leu
             330                 335                 340

 gag acg gcc atc gct gac gcc gag cag cgg ggg gac tgt gcc ctc aag     1108
 Glu Thr Ala Ile Ala Asp Ala Glu Gln Arg Gly Asp Cys Ala Leu Lys
         345                 350                 355

 gat gcc agg gcc aag ctg gat gag ctg gag ggc gcc ctg cag cag gcc     1156
 Asp Ala Arg Ala Lys Leu Asp Glu Leu Glu Gly Ala Leu Gln Gln Ala
     360                 365                 370

 aag gag gag ctg gca cgg atg ctg cgc gag tac caa gag ctt ttg agc     1204
 Lys Glu Glu Leu Ala Arg Met Leu Arg Glu Tyr Gln Glu Leu Leu Ser
 375                 380                 385                 390

 gtg aag ctg tcc ctg gat att gag atc gcc acc tac cgc aag ctg ctg     1252
 Val Lys Leu Ser Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu
                 395                 400                 405

 gag ggc gag gag tgc agg atg tcc gga gaa tat acc aac tcc gtg agc     1300
 Glu Gly Glu Glu Cys Arg Met Ser Gly Glu Tyr Thr Asn Ser Val Ser
             410                 415                 420

 att tcg gtc atc aac agc tcc atg gcc ggg atg gca ggc aca ggg gct     1348
 Ile Ser Val Ile Asn Ser Ser Met Ala Gly Met Ala Gly Thr Gly Ala
         425                 430                 435

 ggc ttt gga ttc agc aat gct ggc acc tac ggc tac tgg ccc agc tct     1396
 Gly Phe Gly Phe Ser Asn Ala Gly Thr Tyr Gly Tyr Trp Pro Ser Ser
     440                 445                 450

 gtc agc ggg ggc tac agc atg ctg cct ggg ggc tgt gtc act ggc agt     1444
 Val Ser Gly Gly Tyr Ser Met Leu Pro Gly Gly Cys Val Thr Gly Ser
 455                 460                 465                 470

 ggg aac tgt agc ccc cgt ggg gaa gcc agg acc agg ctg ggg agt gca     1492
 Gly Asn Cys Ser Pro Arg Gly Glu Ala Arg Thr Arg Leu Gly Ser Ala
                 475                 480                 485

 agt gaa ttc agg gac tcc cag gga aag acc tta gct cta agc tca ccc     1540
 Ser Glu Phe Arg Asp Ser Gln Gly Lys Thr Leu Ala Leu Ser Ser Pro
             490                 495                 500

 acc aaa aaa acc atg aga taa aa gtgcaacaca gcccatttcc cagtagtctg     1593
 Thr Lys Lys Thr Met Arg 
         505

 ccttgccctg gcagactgct ccggactctt ctaggaaatt cctctgtctc              1643




      <210> 468
      <211> 1709
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(1419)

      <400> 468
 aggctccgtt attccagatc gacccacgcg tccggagga   atg aag cgc ctt ctg      54
                                              Met Lys Arg Leu Leu
                                                1               5

 ctt ctg ttt ttg ttc ttt ata aca ttt tct tct gca ttt ccc ttg ggc      102
 Leu Leu Phe Leu Phe Phe Ile Thr Phe Ser Ser Ala Phe Pro Leu Gly
                  10                  15                  20

 cgg atg atg gaa aat gaa gaa aat atg caa ctg gct cag gca tat ctc      150
 Arg Met Met Glu Asn Glu Glu Asn Met Gln Leu Ala Gln Ala Tyr Leu
              25                  30                  35

 aac cag ttc tac tct ctt gaa ata gaa ggg aat cat ctt gtt caa agc      198
 Asn Gln Phe Tyr Ser Leu Glu Ile Glu Gly Asn His Leu Val Gln Ser
          40                  45                  50

 aag aat agg agt ctc ata gat gac aaa att cgg gaa atg caa gca ttt      246
 Lys Asn Arg Ser Leu Ile Asp Asp Lys Ile Arg Glu Met Gln Ala Phe
      55                  60                  65

 ttt gga ttg aca gtg act gga aaa ctg gac tca aac acc ctt gag atc      294
 Phe Gly Leu Thr Val Thr Gly Lys Leu Asp Ser Asn Thr Leu Glu Ile
  70                  75                  80                  85

 atg aag aca ccc agg tgt ggg gtg cct gat gtg ggc cag tat ggc tac      342
 Met Lys Thr Pro Arg Cys Gly Val Pro Asp Val Gly Gln Tyr Gly Tyr
                  90                  95                 100

 acc ctc cct ggg tgg aga aaa tac aac ctc acc tac aga ata ata aac      390
 Thr Leu Pro Gly Trp Arg Lys Tyr Asn Leu Thr Tyr Arg Ile Ile Asn
             105                 110                 115

 tat act ccg gat atg gca cga gct gct gtg gat gag gct atc caa gaa      438
 Tyr Thr Pro Asp Met Ala Arg Ala Ala Val Asp Glu Ala Ile Gln Glu
         120                 125                 130

 ggt tta gaa gtg tgg agc aaa gtc act cca cta aaa ttc acc aag att      486
 Gly Leu Glu Val Trp Ser Lys Val Thr Pro Leu Lys Phe Thr Lys Ile
     135                 140                 145

 tca aag ggg att gca gac atc atg att gcc ttt agg act cga gtc cat      534
 Ser Lys Gly Ile Ala Asp Ile Met Ile Ala Phe Arg Thr Arg Val His
 150                 155                 160                 165

 ggt cgg tgt cct cgc tat ttt gat ggt ccc ttg gga gtg ctt ggc cat      582
 Gly Arg Cys Pro Arg Tyr Phe Asp Gly Pro Leu Gly Val Leu Gly His
                 170                 175                 180

 gcc ttt cct cct ggt ccg ggt ctg ggt ggt gac act cat ttt gat gag      630
 Ala Phe Pro Pro Gly Pro Gly Leu Gly Gly Asp Thr His Phe Asp Glu
             185                 190                 195

 gat gaa aac tgt acc aag gat gga gca gga ggt ctg cct aag gaa cct      678
 Asp Glu Asn Cys Thr Lys Asp Gly Ala Gly Gly Leu Pro Lys Glu Pro
         200                 205                 210

 gct aag cca aag gaa ccc act ata ccc cat gcc tgt gac cct gac ttg      726
 Ala Lys Pro Lys Glu Pro Thr Ile Pro His Ala Cys Asp Pro Asp Leu
     215                 220                 225

 act ttt gac gct atc aca act ttc cgc aga gaa gta atg ttc ttt aaa      774
 Thr Phe Asp Ala Ile Thr Thr Phe Arg Arg Glu Val Met Phe Phe Lys
 230                 235                 240                 245

 ggc agg cac cta tgg agg atc tat tat gat atc acg gat gtt gag ttt      822
 Gly Arg His Leu Trp Arg Ile Tyr Tyr Asp Ile Thr Asp Val Glu Phe
                 250                 255                 260

 gaa tta att gct tca ttc tgg cca tct ctg cca gct gat ctg caa gct      870
 Glu Leu Ile Ala Ser Phe Trp Pro Ser Leu Pro Ala Asp Leu Gln Ala
             265                 270                 275

 gca tac gag aac ccc aga gat aag att ctg gtt ttt aaa gat gaa aac      918
 Ala Tyr Glu Asn Pro Arg Asp Lys Ile Leu Val Phe Lys Asp Glu Asn
         280                 285                 290

 ttc tgg atg atc aga gga tat gct gtc ttg cca gat tat ccc aaa tcc      966
 Phe Trp Met Ile Arg Gly Tyr Ala Val Leu Pro Asp Tyr Pro Lys Ser
     295                 300                 305

 atc cat aca tta ggt ttt cca gga cgt gtg aag aaa ata gat gca gcc     1014
 Ile His Thr Leu Gly Phe Pro Gly Arg Val Lys Lys Ile Asp Ala Ala
 310                 315                 320                 325

 gtc tgt gat aag acc aca aga aaa acc tac ttc ttt gtg ggc att tgg     1062
 Val Cys Asp Lys Thr Thr Arg Lys Thr Tyr Phe Phe Val Gly Ile Trp
                 330                 335                 340

 tgc tgg agg ttt gat gaa atg acc caa acc atg gac aaa ggg ttc ccg     1110
 Cys Trp Arg Phe Asp Glu Met Thr Gln Thr Met Asp Lys Gly Phe Pro
             345                 350                 355

 cag aga gtg gta aaa cac ttt cct gga atc agt atc cgt gtt gat gct     1158
 Gln Arg Val Val Lys His Phe Pro Gly Ile Ser Ile Arg Val Asp Ala
         360                 365                 370

 gct ttc cag tac aaa gga ttc ttc ttt ttc agc cgt gga tca aag caa     1206
 Ala Phe Gln Tyr Lys Gly Phe Phe Phe Phe Ser Arg Gly Ser Lys Gln
     375                 380                 385

 ttt gaa tac gac att aag aca aag aat att acc cga atc atg aga act     1254
 Phe Glu Tyr Asp Ile Lys Thr Lys Asn Ile Thr Arg Ile Met Arg Thr
 390                 395                 400                 405

 aat act tgg ttt caa tgc aaa gaa cca aag aac tcc tca ttt ggt ttt     1302
 Asn Thr Trp Phe Gln Cys Lys Glu Pro Lys Asn Ser Ser Phe Gly Phe
                 410                 415                 420

 gat atc aac aag gaa aaa gca cat tca gga ggc ata aag ata ttg tat     1350
 Asp Ile Asn Lys Glu Lys Ala His Ser Gly Gly Ile Lys Ile Leu Tyr
             425                 430                 435

 cat aag agt tta agc ttg ttt att ttt ggt att gtt cat ttg ctg aaa     1398
 His Lys Ser Leu Ser Leu Phe Ile Phe Gly Ile Val His Leu Leu Lys
         440                 445                 450

 aac act tct att tat caa taa at tcatagacct aaaataaacc tcaacaggtc     1451
 Asn Thr Ser Ile Tyr Gln 
     455

 ttttaatata aattctgctt caaaatagaa taaaaccatt ctttaacaac aagttgctgg   1511

 tcctagttct aaatatccaa attcaatggc cattttgagc tgcctgattc ttttaatagg   1571

 aagttattat gtagaaacaa aaatctctga ctgtacttta agcctatttc atgctttgtg   1631

 gacttggaga agacatgtct tataactgaa tactgaaaca tttattaaac caatctttag   1691

 cattctaaaa aaaaaaaa                                                 1709




      <210> 469
      <211> 1709
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(1419)

      <400> 469
 aggctccgtt attccagatc gacccacgcg tccggagga   atg aag cgc ctt ctg      54
                                              Met Lys Arg Leu Leu
                                                1               5

 ctt ctg ttt ttg ttc ttt ata aca ttt tct tct gca ttt ccc ttg ggc      102
 Leu Leu Phe Leu Phe Phe Ile Thr Phe Ser Ser Ala Phe Pro Leu Gly
                  10                  15                  20

 cgg atg atg gaa aat gaa gaa aat atg caa ctg gct cag gca tat ctc      150
 Arg Met Met Glu Asn Glu Glu Asn Met Gln Leu Ala Gln Ala Tyr Leu
              25                  30                  35

 aac cag ttc tac tct ctt gaa ata gaa ggg aat cat ctt gtt caa agc      198
 Asn Gln Phe Tyr Ser Leu Glu Ile Glu Gly Asn His Leu Val Gln Ser
          40                  45                  50

 aag aat agg agt ctc ata gat gac aaa att cgg gaa atg caa gca ttt      246
 Lys Asn Arg Ser Leu Ile Asp Asp Lys Ile Arg Glu Met Gln Ala Phe
      55                  60                  65

 ttt gga ttg aca gtg act gga aaa ctg gac tca aac acc ctt gag atc      294
 Phe Gly Leu Thr Val Thr Gly Lys Leu Asp Ser Asn Thr Leu Glu Ile
  70                  75                  80                  85

 atg aag aca ccc agg tgt ggg gtg cct gat gtg ggc cag tat ggc tac      342
 Met Lys Thr Pro Arg Cys Gly Val Pro Asp Val Gly Gln Tyr Gly Tyr
                  90                  95                 100

 acc ctc cct ggg tgg aga aaa tac aac ctc acc tac aga ata ata aac      390
 Thr Leu Pro Gly Trp Arg Lys Tyr Asn Leu Thr Tyr Arg Ile Ile Asn
             105                 110                 115

 tat act ccg gat atg gca cga gct gct gtg gat gag gct atc caa gaa      438
 Tyr Thr Pro Asp Met Ala Arg Ala Ala Val Asp Glu Ala Ile Gln Glu
         120                 125                 130

 ggt tta gaa gtg tgg agc aaa gtc act cca cta aaa ttc acc aag att      486
 Gly Leu Glu Val Trp Ser Lys Val Thr Pro Leu Lys Phe Thr Lys Ile
     135                 140                 145

 tca aag ggg att gca gac atc atg att gcc ttt agg act cga gtc cat      534
 Ser Lys Gly Ile Ala Asp Ile Met Ile Ala Phe Arg Thr Arg Val His
 150                 155                 160                 165

 ggt cgg tgt cct cgc tat ttt gat ggt ccc ttg gga gtg ctt ggc cat      582
 Gly Arg Cys Pro Arg Tyr Phe Asp Gly Pro Leu Gly Val Leu Gly His
                 170                 175                 180

 gcc ttt cct cct ggt ccg ggt ctg ggt ggt gac act cat ttt gat gag      630
 Ala Phe Pro Pro Gly Pro Gly Leu Gly Gly Asp Thr His Phe Asp Glu
             185                 190                 195

 gat gaa aac tgt acc aag gat gga gca gga ggt ctg cct aag gaa cct      678
 Asp Glu Asn Cys Thr Lys Asp Gly Ala Gly Gly Leu Pro Lys Glu Pro
         200                 205                 210

 gct aag cca aag gaa ccc act ata ccc cat gcc tgt gac cct gac ttg      726
 Ala Lys Pro Lys Glu Pro Thr Ile Pro His Ala Cys Asp Pro Asp Leu
     215                 220                 225

 act ttt gac gct atc aca act ttc cgc aga gaa gta atg ttc ttt aaa      774
 Thr Phe Asp Ala Ile Thr Thr Phe Arg Arg Glu Val Met Phe Phe Lys
 230                 235                 240                 245

 ggc agg cac cta tgg agg atc tat tat gat atc acg gat gtt gag ttt      822
 Gly Arg His Leu Trp Arg Ile Tyr Tyr Asp Ile Thr Asp Val Glu Phe
                 250                 255                 260

 gaa tta att gct tca ttc tgg cca tct ctg cca gct gat ctg caa gct      870
 Glu Leu Ile Ala Ser Phe Trp Pro Ser Leu Pro Ala Asp Leu Gln Ala
             265                 270                 275

 gca tac gag aac ccc aga gat aag att ctg gtt ttt aaa gat gaa aac      918
 Ala Tyr Glu Asn Pro Arg Asp Lys Ile Leu Val Phe Lys Asp Glu Asn
         280                 285                 290

 ttc tgg atg atc aga gga tat gct gtc ttg cca gat tat ccc aaa tcc      966
 Phe Trp Met Ile Arg Gly Tyr Ala Val Leu Pro Asp Tyr Pro Lys Ser
     295                 300                 305

 atc cat aca tta ggt ttt cca gga cgt gtg aag aaa ata gat gca gcc     1014
 Ile His Thr Leu Gly Phe Pro Gly Arg Val Lys Lys Ile Asp Ala Ala
 310                 315                 320                 325

 gtc tgt gat aag acc aca aga aaa acc tac ttc ttt gtg ggc att tgg     1062
 Val Cys Asp Lys Thr Thr Arg Lys Thr Tyr Phe Phe Val Gly Ile Trp
                 330                 335                 340

 tgc tgg agg ttt gat gaa atg acc caa acc atg gac aaa ggg ttc ccg     1110
 Cys Trp Arg Phe Asp Glu Met Thr Gln Thr Met Asp Lys Gly Phe Pro
             345                 350                 355

 cag aga gtg gta aaa cac ttt cct gga atc agt atc cgt gtt gat gct     1158
 Gln Arg Val Val Lys His Phe Pro Gly Ile Ser Ile Arg Val Asp Ala
         360                 365                 370

 gct ttc cag tac aaa gga ttc ttc ttt ttc agc cgt gga tca aag caa     1206
 Ala Phe Gln Tyr Lys Gly Phe Phe Phe Phe Ser Arg Gly Ser Lys Gln
     375                 380                 385

 ttt gaa tac gac att aag aca aag aat att acc cga atc atg aga act     1254
 Phe Glu Tyr Asp Ile Lys Thr Lys Asn Ile Thr Arg Ile Met Arg Thr
 390                 395                 400                 405

 aat act tgg ttt caa tgc aaa gaa cca aag aac tcc tca ttt ggt ttt     1302
 Asn Thr Trp Phe Gln Cys Lys Glu Pro Lys Asn Ser Ser Phe Gly Phe
                 410                 415                 420

 gat atc aac aag gaa aaa gca cat tca gga ggc ata aag ata ttg tat     1350
 Asp Ile Asn Lys Glu Lys Ala His Ser Gly Gly Ile Lys Ile Leu Tyr
             425                 430                 435

 cat aag agt tta agc ttg ttt att ttt ggt att gtt cat ttg ctg aaa     1398
 His Lys Ser Leu Ser Leu Phe Ile Phe Gly Ile Val His Leu Leu Lys
         440                 445                 450

 aac act tct att tat caa taa at tcatagacct aaaataaacc tcaacaggtc     1451
 Asn Thr Ser Ile Tyr Gln 
     455

 ttttaatata aattctgctt caaaatagaa taaaaccatt ctttaacaac aagttgctgg   1511

 tcctagttct aaatatccaa attcaatggc cattttgagc tgcctgattc ttttaatagg   1571

 aagttattat gtagaaacaa aaatctctga ctgtacttta agcctatttc atgctttgtg   1631

 gacttggaga agacatgtct tataactgaa tactgaaaca tttattaaac caatctttag   1691

 cattctaaaa aaaaaaaa                                                 1709




      <210> 470
      <211> 1883
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1455)

      <220>
      <221> misc_feature
      <222> (1)...(1883)
      <223> n = a,t,c or g

      <400> 470
  atg gcg gag ctg cgg cct agc ggc gcc ccc ggc ccc acc gcg ccc ccg      48
  Met Ala Glu Leu Arg Pro Ser Gly Ala Pro Gly Pro Thr Ala Pro Pro
    1               5                  10                  15

 gcc cct ggc ccg act gcc ccc ccg gct ttc gct tcg ctc ttt ccc ccg       96
 Ala Pro Gly Pro Thr Ala Pro Pro Ala Phe Ala Ser Leu Phe Pro Pro
              20                  25                  30

 gga ctg cac gcc atc tac gga gag tgc cgc cgc ctt tac cct gac cag      144
 Gly Leu His Ala Ile Tyr Gly Glu Cys Arg Arg Leu Tyr Pro Asp Gln
          35                  40                  45

 ccg aac ccg ctc cag gtt acc gct atc gtc aag tac tgg ttg ggt ggc      192
 Pro Asn Pro Leu Gln Val Thr Ala Ile Val Lys Tyr Trp Leu Gly Gly
      50                  55                  60

 cca gac ccc ttg gac tat gtt agc atg tac agg aat gtg ggg agc cct      240
 Pro Asp Pro Leu Asp Tyr Val Ser Met Tyr Arg Asn Val Gly Ser Pro
  65                  70                  75                  80

 tct gct aac atc ccc gag cac tgg cac tac atc agc ttc ggc ctg agt      288
 Ser Ala Asn Ile Pro Glu His Trp His Tyr Ile Ser Phe Gly Leu Ser
                  85                  90                  95

 gat ctc tat ggt gac aac aga gtc cat gag ttt aca gga aca gat gga      336
 Asp Leu Tyr Gly Asp Asn Arg Val His Glu Phe Thr Gly Thr Asp Gly
             100                 105                 110

 cct agt ggt ttt ggc ttt gag ttg acc ttt cgt ctg aag aga gaa act      384
 Pro Ser Gly Phe Gly Phe Glu Leu Thr Phe Arg Leu Lys Arg Glu Thr
         115                 120                 125

 ggg gag tct gcc cca cca aca tgg ccc gca gag tta atg cag ggc ttg      432
 Gly Glu Ser Ala Pro Pro Thr Trp Pro Ala Glu Leu Met Gln Gly Leu
     130                 135                 140

 gca cga tac gtg ttc cag tca gag aac acc ttc tgc agt ggg gac cat      480
 Ala Arg Tyr Val Phe Gln Ser Glu Asn Thr Phe Cys Ser Gly Asp His
 145                 150                 155                 160

 gtg tcc tgg cac agc cct ttg gat aac agt gag tca aga att cag cac      528
 Val Ser Trp His Ser Pro Leu Asp Asn Ser Glu Ser Arg Ile Gln His
                 165                 170                 175

 atg ctg ctg aca gag gac cca cag atg cag ccc gtg cag aca ccc ttt      576
 Met Leu Leu Thr Glu Asp Pro Gln Met Gln Pro Val Gln Thr Pro Phe
             180                 185                 190

 ggg gta gtt acc ttc ctc cag atc gtt ggt gtc tgc act gaa gag cta      624
 Gly Val Val Thr Phe Leu Gln Ile Val Gly Val Cys Thr Glu Glu Leu
         195                 200                 205

 cac tca gcc cag cag tgg aac ggg cag ggc atc ctg gag ctg ctg cgg      672
 His Ser Ala Gln Gln Trp Asn Gly Gln Gly Ile Leu Glu Leu Leu Arg
     210                 215                 220

 aca gtg cct att gct ggc ggc ccc tgg ctg ata act gac atg cgg agg      720
 Thr Val Pro Ile Ala Gly Gly Pro Trp Leu Ile Thr Asp Met Arg Arg
 225                 230                 235                 240

 gga gag acc ata ttt gag atc gat cca cac ctg caa gag aga gtt gac      768
 Gly Glu Thr Ile Phe Glu Ile Asp Pro His Leu Gln Glu Arg Val Asp
                 245                 250                 255

 aaa ggc atc gag aca gat ggc tcc aac ctg agt ggt gtc agt gcc aag      816
 Lys Gly Ile Glu Thr Asp Gly Ser Asn Leu Ser Gly Val Ser Ala Lys
             260                 265                 270

 tgt gcc tgg gat gac ctg agc cgg ccc ccc gag gat gac gag gac agc      864
 Cys Ala Trp Asp Asp Leu Ser Arg Pro Pro Glu Asp Asp Glu Asp Ser
         275                 280                 285

 cgg agc atc tgc atc ggc aca cag ccc cgg cga ctc tct ggc aaa gac      912
 Arg Ser Ile Cys Ile Gly Thr Gln Pro Arg Arg Leu Ser Gly Lys Asp
     290                 295                 300

 aca gag cag atc cgg gag acc ctg agg aga gga ctc gag atc aac agc      960
 Thr Glu Gln Ile Arg Glu Thr Leu Arg Arg Gly Leu Glu Ile Asn Ser
 305                 310                 315                 320

 aaa cct gtc ctt cca cca atc aac cct cag cgg cag aat ggc ctc gcc     1008
 Lys Pro Val Leu Pro Pro Ile Asn Pro Gln Arg Gln Asn Gly Leu Ala
                 325                 330                 335

 cac gac cgg gcc ccg agc cgc aaa gac agc ctg gaa agt gac agc tcc     1056
 His Asp Arg Ala Pro Ser Arg Lys Asp Ser Leu Glu Ser Asp Ser Ser
             340                 345                 350

 acg gcc atc att ccc cat gag ctg att cgc acg cgg cag ctt gag agc     1104
 Thr Ala Ile Ile Pro His Glu Leu Ile Arg Thr Arg Gln Leu Glu Ser
         355                 360                 365

 gta cat ctg aaa ttc aac cag gag tcc gga gcc ctc att cct ctc tgc     1152
 Val His Leu Lys Phe Asn Gln Glu Ser Gly Ala Leu Ile Pro Leu Cys
     370                 375                 380

 cta agg ggc agg ctc ctg cat gga cgg cac ttt aca tat aaa agt atc     1200
 Leu Arg Gly Arg Leu Leu His Gly Arg His Phe Thr Tyr Lys Ser Ile
 385                 390                 395                 400

 aca ggt gac atg gcc atc acg ttt gtc tcc acg gga gtg gaa ggc gcc     1248
 Thr Gly Asp Met Ala Ile Thr Phe Val Ser Thr Gly Val Glu Gly Ala
                 405                 410                 415

 ttt gcc act gag gag cat cct tac gcg gct cat gga ccc tgg tta caa     1296
 Phe Ala Thr Glu Glu His Pro Tyr Ala Ala His Gly Pro Trp Leu Gln
             420                 425                 430

 att ctg ttg acc gaa gag ttt gta gag aaa atg ttg gag gat tta gaa     1344
 Ile Leu Leu Thr Glu Glu Phe Val Glu Lys Met Leu Glu Asp Leu Glu
         435                 440                 445

 gat ttg act tct cca gag gaa ttc aaa ctt ccc aaa gag tac agc tgg     1392
 Asp Leu Thr Ser Pro Glu Glu Phe Lys Leu Pro Lys Glu Tyr Ser Trp
     450                 455                 460

 cct gaa aag aag ctg aag gtc tcc atc ctg cct gac gtg gtg ttc gac     1440
 Pro Glu Lys Lys Leu Lys Val Ser Ile Leu Pro Asp Val Val Phe Asp
 465                 470                 475                 480

 agt ccg cta cac tag cctgggctgg gccctgcagg ggccagcagg gagcccagct     1495
 Ser Pro Leu His 


 gctccccagt gacttccagt gtaacagttg tgtcaacgag atctccacaa ataaaaggac   1555

 aagtgtgagg aagactgcgc agtgccaccc cgcagcccag tggggtgcca tgcacaggcc   1615

 acaggccctc cacctcacct ccagctcagg ggccgcaccc cgccgctggc taagccttgt   1675

 gacccatcag gccagtgagt gggcaaatgc ggaccctccc tgcctgcagc ctgcacagat   1735

 tctggtttga ggtttgactc tggaccctgg ctgtgcccct aggtggagac agccctcttt   1795

 ctcacctacc ccctgccgca cagcccanca angagggagg cggacagccc agatgcaata   1855

 gcgagtggat ncacttncca nctcatct                                      1883




      <210> 471
      <211> 2069
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(1617)

      <400> 471
 ttgaggacac cttgattaac ctccaagggc aactaaagga tcaagaaagg cccagcacag     60

 cagaagatca gctggatcta gctcctgcag gag atg tgt aca aag aca atc cca     114
                                      Met Cys Thr Lys Thr Ile Pro
                                        1               5

 gtc ctc tgg gga tgt ttc ctc ctg tgg aat ctc tat gtc tca tcc tct      162
 Val Leu Trp Gly Cys Phe Leu Leu Trp Asn Leu Tyr Val Ser Ser Ser
          10                  15                  20

 cag acc att tac cct gga atc aag gca agg att act cag agg gca ctt      210
 Gln Thr Ile Tyr Pro Gly Ile Lys Ala Arg Ile Thr Gln Arg Ala Leu
      25                  30                  35

 gac tat ggt gtt caa gct gga atg aag atg att gag caa atg cta aaa      258
 Asp Tyr Gly Val Gln Ala Gly Met Lys Met Ile Glu Gln Met Leu Lys
  40                  45                  50                  55

 gaa aag aaa ctc cca gat tta agc ggt tct gag tct ctt gaa ttt cta      306
 Glu Lys Lys Leu Pro Asp Leu Ser Gly Ser Glu Ser Leu Glu Phe Leu
                  60                  65                  70

 aaa gtt gat tat gta aac tac aat ttt tca aat ata aaa atc agt gcc      354
 Lys Val Asp Tyr Val Asn Tyr Asn Phe Ser Asn Ile Lys Ile Ser Ala
              75                  80                  85

 ttt tca ttt cca aat acc tca ttg gct ttt gtg cct gga gtg gga atc      402
 Phe Ser Phe Pro Asn Thr Ser Leu Ala Phe Val Pro Gly Val Gly Ile
          90                  95                 100

 aaa gcg cta acc aac cat ggc act gcc aac atc agc aca gac tgg ggg      450
 Lys Ala Leu Thr Asn His Gly Thr Ala Asn Ile Ser Thr Asp Trp Gly
     105                 110                 115

 ttc gag tct cca ctt ttc caa gac aca gga ggg gct gat ctg ttt ctc      498
 Phe Glu Ser Pro Leu Phe Gln Asp Thr Gly Gly Ala Asp Leu Phe Leu
 120                 125                 130                 135

 tcc gga gtc tac ttt acc ggt atc att atc cta acc cga aat gac ttt      546
 Ser Gly Val Tyr Phe Thr Gly Ile Ile Ile Leu Thr Arg Asn Asp Phe
                 140                 145                 150

 ggt cat cct acc ctg aag ctc caa gat tgc tac gcc caa ctg agc cat      594
 Gly His Pro Thr Leu Lys Leu Gln Asp Cys Tyr Ala Gln Leu Ser His
             155                 160                 165

 gcc cac gtc tca ttt tcc gga gaa ctc agt gtt ctg tat aac tcc ttt      642
 Ala His Val Ser Phe Ser Gly Glu Leu Ser Val Leu Tyr Asn Ser Phe
         170                 175                 180

 gct gag ccc atg gag aaa ccc att tta aag aac tta aat gaa atg ctc      690
 Ala Glu Pro Met Glu Lys Pro Ile Leu Lys Asn Leu Asn Glu Met Leu
     185                 190                 195

 tgt ccc att att gca agt gaa gtc aaa gcg cta aat gcc aac ctc agc      738
 Cys Pro Ile Ile Ala Ser Glu Val Lys Ala Leu Asn Ala Asn Leu Ser
 200                 205                 210                 215

 aca ctg gag gtt tta acc aag att gac aac tac act ctg ctg gat tac      786
 Thr Leu Glu Val Leu Thr Lys Ile Asp Asn Tyr Thr Leu Leu Asp Tyr
                 220                 225                 230

 tcc cta atc agt tct cca gaa att act gag aac tac ctt gac ctg aac      834
 Ser Leu Ile Ser Ser Pro Glu Ile Thr Glu Asn Tyr Leu Asp Leu Asn
             235                 240                 245

 ttg aag ggt gta ttc tac cca ctg gaa aac ctc acc gac ccc ccc ttc      882
 Leu Lys Gly Val Phe Tyr Pro Leu Glu Asn Leu Thr Asp Pro Pro Phe
         250                 255                 260

 tca cca gtt cct ttt gtg ctc cca gaa cgc agc aac tcc atg ctc tac      930
 Ser Pro Val Pro Phe Val Leu Pro Glu Arg Ser Asn Ser Met Leu Tyr
     265                 270                 275

 att gga atc gcc gag tat ttc ttt aaa tct gcg tcc ttt gct cat ttc      978
 Ile Gly Ile Ala Glu Tyr Phe Phe Lys Ser Ala Ser Phe Ala His Phe
 280                 285                 290                 295

 aca gct ggg gtt ttc aat gtc act ctc tcc acc gaa gag att tcc aac     1026
 Thr Ala Gly Val Phe Asn Val Thr Leu Ser Thr Glu Glu Ile Ser Asn
                 300                 305                 310

 cat ttt gtt caa aac tct caa ggc ctt ggc aac gtg ctc tcc cgg att     1074
 His Phe Val Gln Asn Ser Gln Gly Leu Gly Asn Val Leu Ser Arg Ile
             315                 320                 325

 gca gag atc tac atc ttg tcc cag ccc ttc atg gtg agg atc atg gcc     1122
 Ala Glu Ile Tyr Ile Leu Ser Gln Pro Phe Met Val Arg Ile Met Ala
         330                 335                 340

 aca gag cct ccc ata atc aat cta caa cca ggc aat ttc acc ctg gac     1170
 Thr Glu Pro Pro Ile Ile Asn Leu Gln Pro Gly Asn Phe Thr Leu Asp
     345                 350                 355

 atc cct gcc tcc atc atg atg ctc acc caa ccc aag aac tcc aca gtt     1218
 Ile Pro Ala Ser Ile Met Met Leu Thr Gln Pro Lys Asn Ser Thr Val
 360                 365                 370                 375

 gaa acc atc gtt tcc atg gac ttc gtt gct agt acc agt gtt ggc ctg     1266
 Glu Thr Ile Val Ser Met Asp Phe Val Ala Ser Thr Ser Val Gly Leu
                 380                 385                 390

 gtt att ttg gga caa aga ctg gtc tgc tcc ttg tct ctg aac aga ttc     1314
 Val Ile Leu Gly Gln Arg Leu Val Cys Ser Leu Ser Leu Asn Arg Phe
             395                 400                 405

 cgc ctt gct ttg cca gag tcc aat cgc agc aac att gag gtc ttg agg     1362
 Arg Leu Ala Leu Pro Glu Ser Asn Arg Ser Asn Ile Glu Val Leu Arg
         410                 415                 420

 ttt gaa aat att cta tcg tcc att ctt cac ttt gga gtc ctc cca ctg     1410
 Phe Glu Asn Ile Leu Ser Ser Ile Leu His Phe Gly Val Leu Pro Leu
     425                 430                 435

 gcc aat gca aaa ttg cag caa gga ttt cct ctg tcc aat cca cac aaa     1458
 Ala Asn Ala Lys Leu Gln Gln Gly Phe Pro Leu Ser Asn Pro His Lys
 440                 445                 450                 455

 ttc tta ttc gtc aat tca gat att gaa gtt ctt gag ggt ttc ctt ttg     1506
 Phe Leu Phe Val Asn Ser Asp Ile Glu Val Leu Glu Gly Phe Leu Leu
                 460                 465                 470

 att tcc acc gac ctg aag tat gaa aca tcc tca aag cag cag cca agt     1554
 Ile Ser Thr Asp Leu Lys Tyr Glu Thr Ser Ser Lys Gln Gln Pro Ser
             475                 480                 485

 ttc cac gta tgg gaa ggt ctg aac ctg ata agc aga cag tgg agg ggg     1602
 Phe His Val Trp Glu Gly Leu Asn Leu Ile Ser Arg Gln Trp Arg Gly
         490                 495                 500

 aag tca gcc cct tga ttgccggttt gcaattcacc ccaggaagta aatggtcctt     1657
 Lys Ser Ala Pro 
     505

 aatcctacaa ctactgtaaa cccagaaggg aaagacagta cacactggaa ttgtaaagcc   1717

 cttgtgaatt gcttaggcag aaagttttct ttcttaagcc ttcaggaacc cagaataagg   1777

 cagactctgt taaagggata aatagaggtg tctgaatgtg agtgtatgca tgctgcgtgt   1837

 gtctgtgttt atgtttgttt gtttgtttgg ggcaagaaag attctaggac aagagctagg   1897

 catgtacttc tgaccaggtg ggtaagcaac tctaagtctg tatttgtatt ggtcattctc   1957

 agtggaaatc ccttaggccc tctagtggtt ttcccctacc tgcatattgg ttttcatgtt   2017

 ttatattcac tgttactatc ttctgtgttt aattaaaatt gttttctatc aa           2069




      <210> 472
      <211> 1606
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1155)

      <400> 472
  atg cag aga tcg ccg ccc ggc tac ggc gca cag gac gac ccg ccc gcc      48
  Met Gln Arg Ser Pro Pro Gly Tyr Gly Ala Gln Asp Asp Pro Pro Ala
    1               5                  10                  15

 cgc cgc gac tgt gca tgg gcc ccg gga cac ggg gcc gcc gct gac acg       96
 Arg Arg Asp Cys Ala Trp Ala Pro Gly His Gly Ala Ala Ala Asp Thr
              20                  25                  30

 cgc ggc ctc gcc gcc ggc ccc gcc gcc ctc gcc gcg ccc gcc gcg ccc      144
 Arg Gly Leu Ala Ala Gly Pro Ala Ala Leu Ala Ala Pro Ala Ala Pro
          35                  40                  45

 gcc tcg ccg ccc agc ccg cag cgc agt ccc ccg cgc agc ccc gag ccg      192
 Ala Ser Pro Pro Ser Pro Gln Arg Ser Pro Pro Arg Ser Pro Glu Pro
      50                  55                  60

 ggg cgc tat ggc ctc agc ccg gcc ggc cgc ggg gaa cgc cag gcg gca      240
 Gly Arg Tyr Gly Leu Ser Pro Ala Gly Arg Gly Glu Arg Gln Ala Ala
  65                  70                  75                  80

 gac gag tcg cgc atc cgg cgg ccc atg aac gcc ttc atg gtg tgg gca      288
 Asp Glu Ser Arg Ile Arg Arg Pro Met Asn Ala Phe Met Val Trp Ala
                  85                  90                  95

 aag gac gag cgc aag cgg ctg gct cag cag aac ccg gac ctg cac aac      336
 Lys Asp Glu Arg Lys Arg Leu Ala Gln Gln Asn Pro Asp Leu His Asn
             100                 105                 110

 gcg gtg ctc agc aag atg ctg ggc aaa gcg tgg aag gag ctg aac gcg      384
 Ala Val Leu Ser Lys Met Leu Gly Lys Ala Trp Lys Glu Leu Asn Ala
         115                 120                 125

 gcg gag aag cgg ccc ttc gtg gag gaa gcc gaa cgg ctg cgc gtg cag      432
 Ala Glu Lys Arg Pro Phe Val Glu Glu Ala Glu Arg Leu Arg Val Gln
     130                 135                 140

 cac ttg cgc gac cac ccc aac tac aag tac cgg ccg cgc cgc aag aag      480
 His Leu Arg Asp His Pro Asn Tyr Lys Tyr Arg Pro Arg Arg Lys Lys
 145                 150                 155                 160

 cag gcg cgc aag gcc cgg cgg ctg gag ccc ggc ctc ctg ctc ccg gga      528
 Gln Ala Arg Lys Ala Arg Arg Leu Glu Pro Gly Leu Leu Leu Pro Gly
                 165                 170                 175

 tta gcg ccc ccg cag cca ccg ccc gag cct ttc ccc gcg gcg tct ggc      576
 Leu Ala Pro Pro Gln Pro Pro Pro Glu Pro Phe Pro Ala Ala Ser Gly
             180                 185                 190

 tcg gct cgc gcc ttc cgc gag ctg ccc ccg ctg ggc gcc gag ttc gac      624
 Ser Ala Arg Ala Phe Arg Glu Leu Pro Pro Leu Gly Ala Glu Phe Asp
         195                 200                 205

 ggc ctg ggg ctg ccc acg ccc gag cgc tcg cct ctg gac ggc ctg gag      672
 Gly Leu Gly Leu Pro Thr Pro Glu Arg Ser Pro Leu Asp Gly Leu Glu
     210                 215                 220

 ccc ggc gag gct gcc ttc ttc cca ccg ccc gcg gcg ccc gag gac tgc      720
 Pro Gly Glu Ala Ala Phe Phe Pro Pro Pro Ala Ala Pro Glu Asp Cys
 225                 230                 235                 240

 gcg ctg cgg ccc ttc cgc gcg ccc tac gcg ccc acc gag ttg tcg cgg      768
 Ala Leu Arg Pro Phe Arg Ala Pro Tyr Ala Pro Thr Glu Leu Ser Arg
                 245                 250                 255

 gac ccc ggc ggt tgc tac ggg gct ccc ctg gcg gag gcg ctc agg acc      816
 Asp Pro Gly Gly Cys Tyr Gly Ala Pro Leu Ala Glu Ala Leu Arg Thr
             260                 265                 270

 gcg ccc ccc gcg gcg ccg ctc gct ggc ctg tac tac ggc acc ctg ggc      864
 Ala Pro Pro Ala Ala Pro Leu Ala Gly Leu Tyr Tyr Gly Thr Leu Gly
         275                 280                 285

 acg ccc ggc ccg tac ccc ggc ccg ctg tcg ccg ccg ccc gag gcc ccg      912
 Thr Pro Gly Pro Tyr Pro Gly Pro Leu Ser Pro Pro Pro Glu Ala Pro
     290                 295                 300

 ccg ctg gag agc gcc gag ccg ctg ggg ccc gcc gcc gat ctg tgg gcc      960
 Pro Leu Glu Ser Ala Glu Pro Leu Gly Pro Ala Ala Asp Leu Trp Ala
 305                 310                 315                 320

 gac gtg gac ctc acc gag ttc gac cag tac ctc aac tgc agc cgg act     1008
 Asp Val Asp Leu Thr Glu Phe Asp Gln Tyr Leu Asn Cys Ser Arg Thr
                 325                 330                 335

 cgg ccc gac gcc ccc ggg ctc ccg tac cac gtg gca ctg gcc aaa ctg     1056
 Arg Pro Asp Ala Pro Gly Leu Pro Tyr His Val Ala Leu Ala Lys Leu
             340                 345                 350

 ggc ccg cgc gcc atg tcc tgc cca gag gag agc agc ctg atc tcc gcg     1104
 Gly Pro Arg Ala Met Ser Cys Pro Glu Glu Ser Ser Leu Ile Ser Ala
         355                 360                 365

 ctg tcg gac gcc agc agc gcg gtc tat tac agc gcg tgc atc tcc ggc     1152
 Leu Ser Asp Ala Ser Ser Ala Val Tyr Tyr Ser Ala Cys Ile Ser Gly
     370                 375                 380

 tag gccg ccggcgccgc ccgggtccct gcagcgcttc ctcccgcagc ccccgcgacc     1209
 


 gatccgaccg cgtcgctgcc gctctgctct ctcatacgcg tgtatgtttg gttccatgtc   1269

 acagccccct aggagccagt gatgctcggc cttgcgcccg ttccacctcc caggccaccc   1329

 ttcctgggct tctgggccac ctgccctcgg ggggcccctg cgagggtgcc tggagttccc   1389

 acgtgtcccg gggcttttcc aggaagcccg agcccaggac ctgttggcag agttgccagg   1449

 gttacatttt tgaagcacct gctccttttc ttgcagtgta ttttctacaa ccagattgta   1509

 ttaatatttt ttactttgcc cttttaaaaa atatacctaa tacaatatat ttaattttta   1569

 attaaactct taaacttttc ttccaaaaaa aaaaaaa                            1606




      <210> 473
      <211> 791
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(763)

      <400> 473
 cttcaggcca ctggctaccg aaccccgggg ctcttcacca gtccagctcg tttccagcac     60

 c    atg tcg gtg cgg acg cta ccg ctg ctc ttc ttg aac ttg ggc ggg     106
      Met Ser Val Arg Thr Leu Pro Leu Leu Phe Leu Asn Leu Gly Gly
        1               5                  10                  15

 gag atg ctt tac att ctc gac caa cgg ctg cgg gcc cag aac atc ccg      154
 Glu Met Leu Tyr Ile Leu Asp Gln Arg Leu Arg Ala Gln Asn Ile Pro
                  20                  25                  30

 gga gac aag gcc cgc aaa gat gaa tgg aca gag gtg gac aga aaa cga      202
 Gly Asp Lys Ala Arg Lys Asp Glu Trp Thr Glu Val Asp Arg Lys Arg
              35                  40                  45

 gtt ctg aat gac atc atc tcc acc atg ttc aat aga aag ttt atg gag      250
 Val Leu Asn Asp Ile Ile Ser Thr Met Phe Asn Arg Lys Phe Met Glu
          50                  55                  60

 gaa tta ttc aag cct caa gag ctc tac tcc aag aag gcc ctg agg act      298
 Glu Leu Phe Lys Pro Gln Glu Leu Tyr Ser Lys Lys Ala Leu Arg Thr
      65                  70                  75

 gtc tat gag cgc ctg gct cat gcc tcc att atg aaa ctg aac cag gcc      346
 Val Tyr Glu Arg Leu Ala His Ala Ser Ile Met Lys Leu Asn Gln Ala
  80                  85                  90                  95

 agc atg gat aag ctc tat gac ctg atg acc atg gct ttc aaa tat caa      394
 Ser Met Asp Lys Leu Tyr Asp Leu Met Thr Met Ala Phe Lys Tyr Gln
                 100                 105                 110

 gta ttg ctg tgt ccc cga ccc aag gat gtg ctg ctg gtc act ttc aat      442
 Val Leu Leu Cys Pro Arg Pro Lys Asp Val Leu Leu Val Thr Phe Asn
             115                 120                 125

 cac ttg gat acc atc aag gga ttc atc cga gac tcc cca acc atc ctg      490
 His Leu Asp Thr Ile Lys Gly Phe Ile Arg Asp Ser Pro Thr Ile Leu
         130                 135                 140

 cag caa gtg gac gag act ttg cgg cag ctg aca gaa ata tat ggt ggt      538
 Gln Gln Val Asp Glu Thr Leu Arg Gln Leu Thr Glu Ile Tyr Gly Gly
     145                 150                 155

 ctc tct gca ggg gag ttc cag ctg atc cgg cag aca ctc ctc atc ttc      586
 Leu Ser Ala Gly Glu Phe Gln Leu Ile Arg Gln Thr Leu Leu Ile Phe
 160                 165                 170                 175

 ttc caa gac ctg cac atc cga aga gag tgc ttc tgg aag cat atg caa      634
 Phe Gln Asp Leu His Ile Arg Arg Glu Cys Phe Trp Lys His Met Gln
                 180                 185                 190

 gaa act gtt cac agt gca cag tgt tgc ctt cca gga gtg ggg aac tat      682
 Glu Thr Val His Ser Ala Gln Cys Cys Leu Pro Gly Val Gly Asn Tyr
             195                 200                 205

 atg gag gac agg aga agg aga ctg act ttc cat tat gta tac cct ttt      730
 Met Glu Asp Arg Arg Arg Arg Leu Thr Phe His Tyr Val Tyr Pro Phe
         210                 215                 220

 gag aac ttt gag ttt tgt acc tgg gca aaa taa aattttaa aaaggggaag      781
 Glu Asn Phe Glu Phe Cys Thr Trp Ala Lys 
     225                 230

 aaaaaaaaaa                                                           791




      <210> 474
      <211> 791
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(763)

      <400> 474
 cttcaggcca ctggctaccg aaccccgggg ctcttcacca gtccagctcg tttccagcac     60

 c    atg tcg gtg cgg acg cta ccg ctg ctc ttc ttg aac ttg ggc ggg     106
      Met Ser Val Arg Thr Leu Pro Leu Leu Phe Leu Asn Leu Gly Gly
        1               5                  10                  15

 gag atg ctt tac att ctc gac caa cgg ctg cgg gcc cag aac atc ccg      154
 Glu Met Leu Tyr Ile Leu Asp Gln Arg Leu Arg Ala Gln Asn Ile Pro
                  20                  25                  30

 gga gac aag gcc cgc aaa gat gaa tgg aca gag gtg gac aga aaa cga      202
 Gly Asp Lys Ala Arg Lys Asp Glu Trp Thr Glu Val Asp Arg Lys Arg
              35                  40                  45

 gtt ctg aat gac atc atc tcc acc atg ttc aat aga aag ttt atg gag      250
 Val Leu Asn Asp Ile Ile Ser Thr Met Phe Asn Arg Lys Phe Met Glu
          50                  55                  60

 gaa tta ttc aag cct caa gag ctc tac tcc aag aag gcc ctg agg act      298
 Glu Leu Phe Lys Pro Gln Glu Leu Tyr Ser Lys Lys Ala Leu Arg Thr
      65                  70                  75

 gtc tat gag cgc ctg gct cat gcc tcc att atg aaa ctg aac cag gcc      346
 Val Tyr Glu Arg Leu Ala His Ala Ser Ile Met Lys Leu Asn Gln Ala
  80                  85                  90                  95

 agc atg gat aag ctc tat gac ctg atg acc atg gct ttc aaa tat caa      394
 Ser Met Asp Lys Leu Tyr Asp Leu Met Thr Met Ala Phe Lys Tyr Gln
                 100                 105                 110

 gta ttg ctg tgt ccc cga ccc aag gat gtg ctg ctg gtc act ttc aat      442
 Val Leu Leu Cys Pro Arg Pro Lys Asp Val Leu Leu Val Thr Phe Asn
             115                 120                 125

 cac ttg gat acc atc aag gga ttc atc cga gac tcc cca acc atc ctg      490
 His Leu Asp Thr Ile Lys Gly Phe Ile Arg Asp Ser Pro Thr Ile Leu
         130                 135                 140

 cag caa gtg gac gag act ttg cgg cag ctg aca gaa ata tat ggt ggt      538
 Gln Gln Val Asp Glu Thr Leu Arg Gln Leu Thr Glu Ile Tyr Gly Gly
     145                 150                 155

 ctc tct gca ggg gag ttc cag ctg atc cgg cag aca ctc ctc atc ttc      586
 Leu Ser Ala Gly Glu Phe Gln Leu Ile Arg Gln Thr Leu Leu Ile Phe
 160                 165                 170                 175

 ttc caa gac ctg cac atc cga aga gag tgc ttc tgg aag cat atg caa      634
 Phe Gln Asp Leu His Ile Arg Arg Glu Cys Phe Trp Lys His Met Gln
                 180                 185                 190

 gaa act gtt cac agt gca cag tgt tgc ctt cca gga gtg ggg aac tat      682
 Glu Thr Val His Ser Ala Gln Cys Cys Leu Pro Gly Val Gly Asn Tyr
             195                 200                 205

 atg gag gac agg aga agg aga ctg act ttc cat tat gta tac cct ttt      730
 Met Glu Asp Arg Arg Arg Arg Leu Thr Phe His Tyr Val Tyr Pro Phe
         210                 215                 220

 gag aac ttt gag ttt tgt acc tgg gca aaa taa aattttaa aaaggggaag      781
 Glu Asn Phe Glu Phe Cys Thr Trp Ala Lys 
     225                 230

 aaaaaaaaaa                                                           791




      <210> 475
      <211> 3178
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (198)..(2147)

      <400> 475
 ttacgcctgc acgtaccggt ccggaattcc cgggtcgacg atttcgtcgg ccttggctct     60

 tgcgtgtgcg cgctgccttc cgctctagga cccggattta aagagacagg cgctccaacc    120

 gtcgtgggct gcccggcggc ctgtaatgag caagttccga ggcctacggt gagcgccgga    180

 gccggagagg cagctat   atg tct ttg gct ttc aag atc ttc ttt cca caa     230
                      Met Ser Leu Ala Phe Lys Ile Phe Phe Pro Gln
                        1               5                  10

 acc ctc cgt gca ctc agc cga aaa gaa ctg tgc cta ttc cga aaa cat      278
 Thr Leu Arg Ala Leu Ser Arg Lys Glu Leu Cys Leu Phe Arg Lys His
              15                  20                  25

 cac tgg cgt gat gta aga caa ttc agc cag tgg tca gaa aca gat ctg      326
 His Trp Arg Asp Val Arg Gln Phe Ser Gln Trp Ser Glu Thr Asp Leu
          30                  35                  40

 ctt cat gga cat ccc ctc ttc ctg aga aga aag cct gtt cta tca ttc      374
 Leu His Gly His Pro Leu Phe Leu Arg Arg Lys Pro Val Leu Ser Phe
      45                  50                  55

 cag gga agc cat cta aga tca cgt gcc acc tac ctt gtt ttc ttg cca      422
 Gln Gly Ser His Leu Arg Ser Arg Ala Thr Tyr Leu Val Phe Leu Pro
  60                  65                  70                  75

 ggg ttg cat gtg gga ctc tgc agt ggc ccc tgt gag atg gct gag caa      470
 Gly Leu His Val Gly Leu Cys Ser Gly Pro Cys Glu Met Ala Glu Gln
                  80                  85                  90

 cgg ttc tgt gtg gac tat gcc aag cgt ggc aca gct ggc tgc aaa aaa      518
 Arg Phe Cys Val Asp Tyr Ala Lys Arg Gly Thr Ala Gly Cys Lys Lys
              95                 100                 105

 tgc aag gaa aag att gtg aag ggc gta tgc cga att ggc aaa gtg gtg      566
 Cys Lys Glu Lys Ile Val Lys Gly Val Cys Arg Ile Gly Lys Val Val
         110                 115                 120

 ccc aat ccc ttc tca gag tct ggg ggt gat atg aaa gag tgg tac cac      614
 Pro Asn Pro Phe Ser Glu Ser Gly Gly Asp Met Lys Glu Trp Tyr His
     125                 130                 135

 att aaa tgc atg ttt gag aaa cta gag cgg gcc cgg gcc acc aca aaa      662
 Ile Lys Cys Met Phe Glu Lys Leu Glu Arg Ala Arg Ala Thr Thr Lys
 140                 145                 150                 155

 aaa atc gag gac ctc aca gag ctg gaa ggc tgg gaa gag ctg gaa gat      710
 Lys Ile Glu Asp Leu Thr Glu Leu Glu Gly Trp Glu Glu Leu Glu Asp
                 160                 165                 170

 aat gag aag gaa cag ata acc cag cac att gca gat ctg tct tct aag      758
 Asn Glu Lys Glu Gln Ile Thr Gln His Ile Ala Asp Leu Ser Ser Lys
             175                 180                 185

 gca gca ggt aca cca aag aag aaa gct gtt gtc cag gct aag ttg aca      806
 Ala Ala Gly Thr Pro Lys Lys Lys Ala Val Val Gln Ala Lys Leu Thr
         190                 195                 200

 acc act ggc cag gtg act tct cca gtg aaa ggc gcc tca ttt gtc acc      854
 Thr Thr Gly Gln Val Thr Ser Pro Val Lys Gly Ala Ser Phe Val Thr
     205                 210                 215

 agt acc aat ccc cgg aaa ttt tct ggc ttt tca gcc aag ccc aac aac      902
 Ser Thr Asn Pro Arg Lys Phe Ser Gly Phe Ser Ala Lys Pro Asn Asn
 220                 225                 230                 235

 tct ggg gaa gcc ccc tcg agc ccc acc cct aag aga agt ctg tct tca      950
 Ser Gly Glu Ala Pro Ser Ser Pro Thr Pro Lys Arg Ser Leu Ser Ser
                 240                 245                 250

 agc aaa tgt gac ccc agg cat aag gac tgt ctg cta cgg gag ttt cga      998
 Ser Lys Cys Asp Pro Arg His Lys Asp Cys Leu Leu Arg Glu Phe Arg
             255                 260                 265

 aag tta tgc gcc atg gtg gcc gat aat cct agc tac aac acg aag acc     1046
 Lys Leu Cys Ala Met Val Ala Asp Asn Pro Ser Tyr Asn Thr Lys Thr
         270                 275                 280

 cag atc atc cag gac ttc ctt cgg aaa ggc tca gca gga gat ggt ttc     1094
 Gln Ile Ile Gln Asp Phe Leu Arg Lys Gly Ser Ala Gly Asp Gly Phe
     285                 290                 295

 cac ggt gat gtg tac cta aca gtg aag ctg ctg ctg cca gga gtc att     1142
 His Gly Asp Val Tyr Leu Thr Val Lys Leu Leu Leu Pro Gly Val Ile
 300                 305                 310                 315

 aag act gtt tac aac ttg aac gat aag cag att gtg aag ctt ttc agt     1190
 Lys Thr Val Tyr Asn Leu Asn Asp Lys Gln Ile Val Lys Leu Phe Ser
                 320                 325                 330

 cgc att ttt aac tgc aac cca gat gat atg gca cgg gac cta gag cag     1238
 Arg Ile Phe Asn Cys Asn Pro Asp Asp Met Ala Arg Asp Leu Glu Gln
             335                 340                 345

 ggt gac gtg tca gag aca atc aga gtc ttc ttt gag cag agc aag tct     1286
 Gly Asp Val Ser Glu Thr Ile Arg Val Phe Phe Glu Gln Ser Lys Ser
         350                 355                 360

 ttc ccc cca gct gcc aag agc ctc ctt acc atc cag gaa gtg gat gag     1334
 Phe Pro Pro Ala Ala Lys Ser Leu Leu Thr Ile Gln Glu Val Asp Glu
     365                 370                 375

 ttc ctt ctg cgg ctg tcc aag ctc acc aag gag gat gag cag caa cag     1382
 Phe Leu Leu Arg Leu Ser Lys Leu Thr Lys Glu Asp Glu Gln Gln Gln
 380                 385                 390                 395

 gcc cta cag gac att gcc tcc agg tgt aca gcc aat gac ctt aaa tgc     1430
 Ala Leu Gln Asp Ile Ala Ser Arg Cys Thr Ala Asn Asp Leu Lys Cys
                 400                 405                 410

 atc atc agg ttg atc aaa cat gat ctg aag atg aac tca ggt gca aaa     1478
 Ile Ile Arg Leu Ile Lys His Asp Leu Lys Met Asn Ser Gly Ala Lys
             415                 420                 425

 cat gtg tta gac gcc ctt gac ccc aat gcc tat gaa gcc ttc aaa gcc     1526
 His Val Leu Asp Ala Leu Asp Pro Asn Ala Tyr Glu Ala Phe Lys Ala
         430                 435                 440

 tcg cgc aac ctg cag gat gtg gtg gag cgg gtc ctt cac aac gcg cag     1574
 Ser Arg Asn Leu Gln Asp Val Val Glu Arg Val Leu His Asn Ala Gln
     445                 450                 455

 gag gtg gag aag gag ccg ggc cag aga cga gct ctg agc gtc cag gcc     1622
 Glu Val Glu Lys Glu Pro Gly Gln Arg Arg Ala Leu Ser Val Gln Ala
 460                 465                 470                 475

 tcg ctg atg aca cct gtg cag ccc atg ttg gcg gag gcc tgc aag tcc     1670
 Ser Leu Met Thr Pro Val Gln Pro Met Leu Ala Glu Ala Cys Lys Ser
                 480                 485                 490

 gtt gag tat gca atg aag aaa tgt ccc aat ggc atg ttc tct gag atc     1718
 Val Glu Tyr Ala Met Lys Lys Cys Pro Asn Gly Met Phe Ser Glu Ile
             495                 500                 505

 aag tac gat gga gag cga gtc cag gtg cat aag aat gga gac cac ttc     1766
 Lys Tyr Asp Gly Glu Arg Val Gln Val His Lys Asn Gly Asp His Phe
         510                 515                 520

 agc tac ttc agc cgc agt ctc aag ccc gtc ctt cct cac aag gtg gcc     1814
 Ser Tyr Phe Ser Arg Ser Leu Lys Pro Val Leu Pro His Lys Val Ala
     525                 530                 535

 cac ttt aag gac tac att ccc cag gct ttt cct ggg ggc cac agc atg     1862
 His Phe Lys Asp Tyr Ile Pro Gln Ala Phe Pro Gly Gly His Ser Met
 540                 545                 550                 555

 atc ttg gat tct gaa gtg ctt ctg att gac aac aag aca ggc aaa cca     1910
 Ile Leu Asp Ser Glu Val Leu Leu Ile Asp Asn Lys Thr Gly Lys Pro
                 560                 565                 570

 ctg ccc ttt ggg act ctg gga gta cac aag aaa gca gcc ttc cag gat     1958
 Leu Pro Phe Gly Thr Leu Gly Val His Lys Lys Ala Ala Phe Gln Asp
             575                 580                 585

 gct aat gtc tgc ctg ttt gtt ttt gat tgt atc tac ttt aat gat gtc     2006
 Ala Asn Val Cys Leu Phe Val Phe Asp Cys Ile Tyr Phe Asn Asp Val
         590                 595                 600

 agc ttg atg gac aga cct ctg tgt gag cgg cgg aag ttt ctt cat gac     2054
 Ser Leu Met Asp Arg Pro Leu Cys Glu Arg Arg Lys Phe Leu His Asp
     605                 610                 615

 aac atg gtt gaa att cca aac cgg atc atg ttc tca gaa atg aag cga     2102
 Asn Met Val Glu Ile Pro Asn Arg Ile Met Phe Ser Glu Met Lys Arg
 620                 625                 630                 635

 gtc aca cat ctc tct tgt ccc tca gaa agc ttt gga ctt ggc tga cat     2150
 Val Thr His Leu Ser Cys Pro Ser Glu Ser Phe Gly Leu Gly 
                 640                 645

 gataacccgg gtgatccagg ggggattgga ggggctggtg ctgaaggatg tgaagggtac   2210

 atatgagcga tgggaagcgg cactggctga aagtgaagaa agactatttg aacgaggggg   2270

 ccatggccga cacagctgac ctggtggtcc ttggagcctt ctatgggcaa gggagcaaag   2330

 gcggcatgat gtcaatcttc ctcatgggct gctacgaccc tggcagccag aagtggtgca   2390

 cagtcaccaa gtgtgcagga ggccatgatg atgccacgct tgcccgcctg cagaatgaac   2450

 tagacatggt gaagatcagc aaggacccca gcaaaatacc cagctggttg aaggtcaaca   2510

 agatctacta tcctgacttc atcgtcccag acccaaagaa agctgccgtg tgggagatca   2570

 caggggctga attctccaaa tcggaggctc atacagctga cgggatctcc atccgattcc   2630

 ctcgctgcac ccgaatccga gatgataagg actggaaatc tgccactaac cttccccaac   2690

 tcaaggaact gtaccagttg tccaaggaga aggcagactt cactgtagtg gctggagatg   2750

 aggggagctc cactacaggg ggtagcagtg aagagaataa gggtccctca gggtctgctg   2810

 tgtcccgcaa ggcccccagc aagccctcag ccagtaccaa gaaagcagaa gggaagctga   2870

 gtaactccaa cagcaaagat ggcaacatgc agactgcaaa gccttccgct atgaaggtgg   2930

 gggagaagct ggccacaaag tcttctccag tgaaagtagg ggagaagcgg aaagctgctg   2990

 atgagacgct gtgccaaaca aagaggcggc cagccagtga gcagagagga agaactgtgc   3050

 cagcaggcag gagatagaac agcccggcct agccaggaga gactgcaggg actcactcag   3110

 ctgctggccc caagtcaaaa tttacattaa agggaaaagc ccagtctggg tgtggaaaaa   3170

 aaaaaaaa                                                            3178




      <210> 476
      <211> 1496
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(1355)

      <400> 476
 gcttttgtga gcacaagtgt tatctgctcc agagggtggc ctggtatagg aggaaagaga     60

 tcgttataag ttttaca   atg gac tct ctt gtt aca gca aac acc aaa ttt     110
                      Met Asp Ser Leu Val Thr Ala Asn Thr Lys Phe
                        1               5                  10

 tgc ttt gat ctt ttt caa gag ata ggc aaa gat gat cgt cat aaa aac      158
 Cys Phe Asp Leu Phe Gln Glu Ile Gly Lys Asp Asp Arg His Lys Asn
              15                  20                  25

 ata ttt ttc tct ccc ctg agc ctc tca gct gcc ctt ggt atg gta cgc      206
 Ile Phe Phe Ser Pro Leu Ser Leu Ser Ala Ala Leu Gly Met Val Arg
          30                  35                  40

 ctg ggt gct aga agt gac agt gca cat cag att gat gag gta cta cac      254
 Leu Gly Ala Arg Ser Asp Ser Ala His Gln Ile Asp Glu Val Leu His
      45                  50                  55

 ttc aac gaa ttt tcc cag aat gaa agc aaa gaa cct gac cct tgt ctg      302
 Phe Asn Glu Phe Ser Gln Asn Glu Ser Lys Glu Pro Asp Pro Cys Leu
  60                  65                  70                  75

 aaa agc aac aaa caa aaa gtg ctg gct gac agc tct ctg gag ggg cag      350
 Lys Ser Asn Lys Gln Lys Val Leu Ala Asp Ser Ser Leu Glu Gly Gln
                  80                  85                  90

 aaa aaa acg aca gag cct ctg gat cag cag gct ggg tcc tta aac aat      398
 Lys Lys Thr Thr Glu Pro Leu Asp Gln Gln Ala Gly Ser Leu Asn Asn
              95                 100                 105

 gag agc gga ctg gtc agc tgc tac ttt ggg cag ctt ctc tcc aaa tta      446
 Glu Ser Gly Leu Val Ser Cys Tyr Phe Gly Gln Leu Leu Ser Lys Leu
         110                 115                 120

 gac agg atc aag act gat tac aca ctg agt att gcc aac agg ctt tat      494
 Asp Arg Ile Lys Thr Asp Tyr Thr Leu Ser Ile Ala Asn Arg Leu Tyr
     125                 130                 135

 gga gag cag gaa ttc cca atc tgt cag gaa tac tta gat ggt gtg att      542
 Gly Glu Gln Glu Phe Pro Ile Cys Gln Glu Tyr Leu Asp Gly Val Ile
 140                 145                 150                 155

 caa ttt tac cac acg acg att gaa agt gtt gat ttc caa aaa aac cct      590
 Gln Phe Tyr His Thr Thr Ile Glu Ser Val Asp Phe Gln Lys Asn Pro
                 160                 165                 170

 gaa aaa tcc aga caa gag att aac ttc tgg gtt gaa tgt caa tcc caa      638
 Glu Lys Ser Arg Gln Glu Ile Asn Phe Trp Val Glu Cys Gln Ser Gln
             175                 180                 185

 ggt aaa atc aag gaa ctc ttc agc aag gac gct att aat gct gag act      686
 Gly Lys Ile Lys Glu Leu Phe Ser Lys Asp Ala Ile Asn Ala Glu Thr
         190                 195                 200

 gtg ctg gta ctg gtg aat gct gtt tac ttc aag gcc aaa tgg gaa aca      734
 Val Leu Val Leu Val Asn Ala Val Tyr Phe Lys Ala Lys Trp Glu Thr
     205                 210                 215

 tac ttt gac cat gaa aac acg gtg gat gca cct ttc tgt cta aat gcg      782
 Tyr Phe Asp His Glu Asn Thr Val Asp Ala Pro Phe Cys Leu Asn Ala
 220                 225                 230                 235

 aat gaa aac aag agt gtg aag atg atg acg caa aaa ggc ctc tac aga      830
 Asn Glu Asn Lys Ser Val Lys Met Met Thr Gln Lys Gly Leu Tyr Arg
                 240                 245                 250

 att ggc ttc ata gag gag gtg aag gca cag atc ctg gaa atg agg tac      878
 Ile Gly Phe Ile Glu Glu Val Lys Ala Gln Ile Leu Glu Met Arg Tyr
             255                 260                 265

 acc aag ggg aag ctc agc atg ttc gtg ctg ctg cca tct cac tct aaa      926
 Thr Lys Gly Lys Leu Ser Met Phe Val Leu Leu Pro Ser His Ser Lys
         270                 275                 280

 gat aac ctg aag ggt ctg gaa gag ctt gaa agg aaa atc acc tat gaa      974
 Asp Asn Leu Lys Gly Leu Glu Glu Leu Glu Arg Lys Ile Thr Tyr Glu
     285                 290                 295

 aaa atg gtg gcc tgg agc agc tca gaa aac atg tca gaa gaa tcg gtg     1022
 Lys Met Val Ala Trp Ser Ser Ser Glu Asn Met Ser Glu Glu Ser Val
 300                 305                 310                 315

 gtc ctg tcc ttc ccc cgg ttc acc ctg gaa ggc agc tat gat ctc aat     1070
 Val Leu Ser Phe Pro Arg Phe Thr Leu Glu Gly Ser Tyr Asp Leu Asn
                 320                 325                 330

 tcc att tta caa gac atg ggc att acg gat atc ttt gat gaa acg agg     1118
 Ser Ile Leu Gln Asp Met Gly Ile Thr Asp Ile Phe Asp Glu Thr Arg
             335                 340                 345

 gct gat ctt act gga atc tct cca agt ccc aat ttg tac ttg tca aaa     1166
 Ala Asp Leu Thr Gly Ile Ser Pro Ser Pro Asn Leu Tyr Leu Ser Lys
         350                 355                 360

 att atc cac aaa acc ttt gtg gag gtg gat gaa aac ggt acc cag gca     1214
 Ile Ile His Lys Thr Phe Val Glu Val Asp Glu Asn Gly Thr Gln Ala
     365                 370                 375

 gct gca gcc act ggg gct gtt gtc tcg gaa agg tca cta cga tct tgg     1262
 Ala Ala Ala Thr Gly Ala Val Val Ser Glu Arg Ser Leu Arg Ser Trp
 380                 385                 390                 395

 gtg gag ttt aat gcc aac cac cct ttt ctc ttt ttc att aga cac aac     1310
 Val Glu Phe Asn Ala Asn His Pro Phe Leu Phe Phe Ile Arg His Asn
                 400                 405                 410

 aaa acc caa acc att ctc ttt tat ggc agg gtc tgc tct cct taa aag     1358
 Lys Thr Gln Thr Ile Leu Phe Tyr Gly Arg Val Cys Ser Pro 
             415                 420                 425

 gggagcagtg tctagtactt tggagctgga ggaaaatatc aatacaatct tcccctggca   1418

 taagatgggc atttgagttt ttggtaatat ctaaagcatc tccttcatcc tccagccatc   1478

 ggcttgtgct tatcttgg                                                 1496




      <210> 477
      <211> 623
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (85)..(348)

      <400> 477
 ggagttaaag gtctactttg ctctttgtgc ttaagttaga tcagcgttca taatgtcata     60

 gttttctttt ttacaatctg tttc   atg ata ctc ata aat ttt aga gaa atc     111
                              Met Ile Leu Ile Asn Phe Arg Glu Ile
                                1               5

 tgt ctg aag gtt ctg cat aca cct ctg tgt gtt tct ggg ggg tgt gta      159
 Cys Leu Lys Val Leu His Thr Pro Leu Cys Val Ser Gly Gly Cys Val
  10                  15                  20                  25

 ctt tta tac atc tta gct ctg act tgc tgt tat aca aac tca ctc tta      207
 Leu Leu Tyr Ile Leu Ala Leu Thr Cys Cys Tyr Thr Asn Ser Leu Leu
                  30                  35                  40

 ata tcg cat ctc cct ccc ctt tct ctc ccc aca gaa aca caa aca cac      255
 Ile Ser His Leu Pro Pro Leu Ser Leu Pro Thr Glu Thr Gln Thr His
              45                  50                  55

 tta ttt atg tat aga gtc ctg aaa gtc aga aag gac att aaa aac cat      303
 Leu Phe Met Tyr Arg Val Leu Lys Val Arg Lys Asp Ile Lys Asn His
          60                  65                  70

 gta ttc cac cca act tac ttg gta gcc aag gaa aca gaa acc tag gga      351
 Val Phe His Pro Thr Tyr Leu Val Ala Lys Glu Thr Glu Thr 
      75                  80                  85

 gaggagctga ttcccctacc cccttgtagg gagcaccagg actaggccct gggtgtcctg    411

 cttcaggttc agagcttggg atgcagagct tgtccccaga gcaggagctg cagggcctgc    471

 tctccaagct gcctgcactt tcacagatgg atgtcaggtg cctcccaagc tggagtacct    531

 ggaaatgggt aaaaatagtt gaacaagtga gtacagttgg cgaaaagtaa agtcttttta    591

 gacagctttg gaatgattag agaggggact tg                                  623




      <210> 478
      <211> 301
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2)..(286)

      <400> 478
 a    atg ttt tct tac ctc att ctg tgc ccc agt agg ggg tcc agc ctc      46
      Met Phe Ser Tyr Leu Ile Leu Cys Pro Ser Arg Gly Ser Ser Leu
        1               5                  10                  15

 atc tgt ctg gct tgg ccc tgt gtt cct cct gtc ccc tgc tcc act gcc       94
 Ile Cys Leu Ala Trp Pro Cys Val Pro Pro Val Pro Cys Ser Thr Ala
                  20                  25                  30

 tat ctg gtg ccc cag gtg ctg ctt gcc act cca gct gtc aca ttg aac      142
 Tyr Leu Val Pro Gln Val Leu Leu Ala Thr Pro Ala Val Thr Leu Asn
              35                  40                  45

 agt ttc aat tca gct ctt aat gct cct gct tcc gaa gcc tgc cca att      190
 Ser Phe Asn Ser Ala Leu Asn Ala Pro Ala Ser Glu Ala Cys Pro Ile
          50                  55                  60

 tct ttt ttc ttg gcc tct gtt ttt ttt ttt ctt tct ttt tcc ctt gtt      238
 Ser Phe Phe Leu Ala Ser Val Phe Phe Phe Leu Ser Phe Ser Leu Val
      65                  70                  75

 ttt gta gaa gac tca gag gag aat ctt tct tat ggc tcc ctc tgt tga      286
 Phe Val Glu Asp Ser Glu Glu Asn Leu Ser Tyr Gly Ser Leu Cys 
  80                  85                  90

 gattggaatt ggaag                                                     301




      <210> 479
      <211> 1512
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (155)..(1036)

      <400> 479
 taagaaactg aaagaattga accaacgcat tgggaagaca gagtgcagaa ataagcatga     60

 aggaatagct gataaacttt tggcaaaaat agcaaaactt caaagacgta ttaaaacagt    120

 attattattt caaaggaatt gtttgaaacc aaac    atg tta tcc agt aat gga     172
                                          Met Leu Ser Ser Asn Gly
                                            1               5

 gcc tct aag gtt gca aat tca gag gct atg att ttg gat aag aat ctt      220
 Ala Ser Lys Val Ala Asn Ser Glu Ala Met Ile Leu Asp Lys Asn Leu
              10                  15                  20

 gag tca gtt aat agt cca att gaa aag tct tct gtg aat tat gag cct      268
 Glu Ser Val Asn Ser Pro Ile Glu Lys Ser Ser Val Asn Tyr Glu Pro
          25                  30                  35

 tct aac cct tcc gaa aaa gga agt aaa aaa att aat ttg tca tca gat      316
 Ser Asn Pro Ser Glu Lys Gly Ser Lys Lys Ile Asn Leu Ser Ser Asp
      40                  45                  50

 caa aat aag tct gtt tct gaa agt aac aat gat gat gtt atg ttg att      364
 Gln Asn Lys Ser Val Ser Glu Ser Asn Asn Asp Asp Val Met Leu Ile
  55                  60                  65                  70

 tct gtg gaa agt cct aat ttg aca act cca act aca tca aat cca aca      412
 Ser Val Glu Ser Pro Asn Leu Thr Thr Pro Thr Thr Ser Asn Pro Thr
                  75                  80                  85

 gat acc aga aaa att aca tca gga aat tct agc aat tct ccc aat gct      460
 Asp Thr Arg Lys Ile Thr Ser Gly Asn Ser Ser Asn Ser Pro Asn Ala
              90                  95                 100

 gaa gtt atg gct gta cag aag aaa ctt gat tct ata att gat ttg aca      508
 Glu Val Met Ala Val Gln Lys Lys Leu Asp Ser Ile Ile Asp Leu Thr
         105                 110                 115

 aaa gaa ggc cta tcc aac tgc aat aca gaa agt cca gta tcc ccc ctg      556
 Lys Glu Gly Leu Ser Asn Cys Asn Thr Glu Ser Pro Val Ser Pro Leu
     120                 125                 130

 gag tca cat tcg aaa gct gct tca aac tca aag gaa aca acc cca ttg      604
 Glu Ser His Ser Lys Ala Ala Ser Asn Ser Lys Glu Thr Thr Pro Leu
 135                 140                 145                 150

 gca caa aat gca gtc cag gtt cct gag tcc ttt gag cac ctg cca cct      652
 Ala Gln Asn Ala Val Gln Val Pro Glu Ser Phe Glu His Leu Pro Pro
                 155                 160                 165

 ctc cca gaa cca cca gca cca cta cct gaa tta gta gac aaa acc cga      700
 Leu Pro Glu Pro Pro Ala Pro Leu Pro Glu Leu Val Asp Lys Thr Arg
             170                 175                 180

 gac aca ctt cct ccc cag aag cct gag ctc aaa gtg aaa cgg gtt ttc      748
 Asp Thr Leu Pro Pro Gln Lys Pro Glu Leu Lys Val Lys Arg Val Phe
         185                 190                 195

 aga ccc aat ggc att gcc ctg act tgg aat ata acc aaa atc aat ccc      796
 Arg Pro Asn Gly Ile Ala Leu Thr Trp Asn Ile Thr Lys Ile Asn Pro
     200                 205                 210

 aag tgt gct cct gta gaa agc tac cac ctc ttc ctg tgt cat gag aac      844
 Lys Cys Ala Pro Val Glu Ser Tyr His Leu Phe Leu Cys His Glu Asn
 215                 220                 225                 230

 tct aat aat aag ttg att tgg aag aag att gga gaa att aaa gct tta      892
 Ser Asn Asn Lys Leu Ile Trp Lys Lys Ile Gly Glu Ile Lys Ala Leu
                 235                 240                 245

 cca ctc ccc atg gcc tgt act tta tct cag ttt tta gct tcc aac aga      940
 Pro Leu Pro Met Ala Cys Thr Leu Ser Gln Phe Leu Ala Ser Asn Arg
             250                 255                 260

 tac tat ttt act gtc caa tca aaa gat att ttt gga cga tat gga cca      988
 Tyr Tyr Phe Thr Val Gln Ser Lys Asp Ile Phe Gly Arg Tyr Gly Pro
         265                 270                 275

 ttc tgt gat ata aaa tct atc cct ggg ttt tct gaa aat ctt acg taa     1036
 Phe Cys Asp Ile Lys Ser Ile Pro Gly Phe Ser Glu Asn Leu Thr 
     280                 285                 290

 aaggtgttta ataatgatat actacttttt ttttcatatt tgtttgtttg caatgttact   1096

 gtaatactat ttgccattgt aaaaggccag ctcagattgt gagccctttc tattgggaca   1156

 gtcctcttct atatgtttta agtggccagt aatttaatga atttctggtt tgtattaaat   1216

 atgtccttcc aatggataag ttctaaaaca tacgctatca ttggcccatg ttgctgaggt   1276

 gcattgtgaa caataccttt agtgactgtg gaactgctgc ttctatcaga agacctagga   1336

 tacaagcagc cactgtttcc tccgttaaca atcagctttt agtaacctgc tgtggtcagc   1396

 atagctacag gaaaagtcag cccttgactg agggccagat catccctgga gtgcacctct   1456

 actaagattt tatgaaaaga tgacatgttg ggctgcatga taaaagttaa ttataa       1512




      <210> 480
      <211> 408
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (10)..(408)

      <400> 480
 tttcttata    atg cca act ttg tac aag aaa gct ggg tcg gcg cgc cca      48
              Met Pro Thr Leu Tyr Lys Lys Ala Gly Ser Ala Arg Pro
                1               5                  10

 ccc ttc acc atg gac act ctg gtg cta gta tca gtc att ttg atc aca       96
 Pro Phe Thr Met Asp Thr Leu Val Leu Val Ser Val Ile Leu Ile Thr
      15                  20                  25

 aga cgt gga cca gcc cac ctt gga gct cac tgt ggt ggt ggc ctg gtc      144
 Arg Arg Gly Pro Ala His Leu Gly Ala His Cys Gly Gly Gly Leu Val
  30                  35                  40                  45

 cta atg caa gtc cta atg gag ctc ttg gaa ctg gct gta gcc ttt gct      192
 Leu Met Gln Val Leu Met Glu Leu Leu Glu Leu Ala Val Ala Phe Ala
                  50                  55                  60

 gag cag gag caa cta tgt ctc tgg ttc tta agg att gaa aag cca cct      240
 Glu Gln Glu Gln Leu Cys Leu Trp Phe Leu Arg Ile Glu Lys Pro Pro
              65                  70                  75

 cct gcc tct aaa gtg ctt gaa gac aca gta gga agg cac cag agg gca      288
 Pro Ala Ser Lys Val Leu Glu Asp Thr Val Gly Arg His Gln Arg Ala
          80                  85                  90

 ttc tca gac cat cta ttt tca agg aaa tac agc tgg gaa gta caa aac      336
 Phe Ser Asp His Leu Phe Ser Arg Lys Tyr Ser Trp Glu Val Gln Asn
      95                 100                 105

 aat tct cca ctt cgg cca gtt ttg gat gaa atg gtg gtt tct aac aca      384
 Asn Ser Pro Leu Arg Pro Val Leu Asp Glu Met Val Val Ser Asn Thr
 110                 115                 120                 125

 cac tca gaa aca ctt gga gtc tga                                      408
 His Ser Glu Thr Leu Gly Val 
                 130





      <210> 481
      <211> 402
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (107)..(259)

      <400> 481
 atttggccct cgaggccaag aattcggcac gagtgttggg atatcagaaa cttccctaga     60

 aatgtacata tatagagatt gctattagcc ttgaacaaac tagaag   atg tct tcc     115
                                                      Met Ser Ser
                                                        1

 tgg ccc aga atg tta gcc cat tgc ttt tat tta ctt aaa gct tta agt      163
 Trp Pro Arg Met Leu Ala His Cys Phe Tyr Leu Leu Lys Ala Leu Ser
       5                  10                  15

 tcc agc tac cta ata aaa gaa atg aca ata atg cca ggc act ctc cta      211
 Ser Ser Tyr Leu Ile Lys Glu Met Thr Ile Met Pro Gly Thr Leu Leu
  20                  25                  30                  35

 agc act tta tgt ata cta act cac tta aat ctc cca aca cct ctg tga      259
 Ser Thr Leu Cys Ile Leu Thr His Leu Asn Leu Pro Thr Pro Leu 
                  40                  45                  50

 gataaatact actggtattc tcattttaca ggtgtcttct cagtagcaga agtgaattag    319

 ttagaaaagt ttttttactt tagcttaacg tattccttct tatccattcc attacttatt    379

 tatttcatca ctgtccttct tcc                                            402




      <210> 482
      <211> 934
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (342)..(491)

      <400> 482
 tatgaacctc aaggagtctt ctgtatagta tgggaagcag aaatgagaac aaccaataat     60

 acaatgtgat gacaccaata ttaatatatg tgcaaagtgc tcaggaggcc caggtattgg    120

 gacactgact ttacaacgat ggggcagaag tctgagaggt cctgtgtgaa ggaaataggt    180

 agaaactagt tcttcgagga aacgaccccg agttggggtg gtgcaatgga aagcaagtcc    240

 tcttactagg gagttgtttg tttacatctc tagtgtttga cccacagagt cagctcctgg    300

 gttgggtttt tgttttccag actttggaca aagtttacca a    atg aaa agc aaa     353
                                                  Met Lys Ser Lys
                                                    1

 cct cgg gga tac tgt ctg atc atc aac aat cac aat ttt gca aaa gca      401
 Pro Arg Gly Tyr Cys Leu Ile Ile Asn Asn His Asn Phe Ala Lys Ala
   5                  10                  15                  20

 cgg gag aaa gtg ccc aaa ctt cac agc att agg gac agg aat gga aca      449
 Arg Glu Lys Val Pro Lys Leu His Ser Ile Arg Asp Arg Asn Gly Thr
                  25                  30                  35

 cac ttg gat gca ggt aca gta gaa ccc aaa aga gaa aag taa aatattt      498
 His Leu Asp Ala Gly Thr Val Glu Pro Lys Arg Glu Lys 
              40                  45

 cttatgccta ttttttttta aatcaaaagg gagagaacaa aagctatacc aaaagggcca    558

 tgtttcaaga aaatggattt aaacatattt ccctgtggag gtaaagaaca ttcttataca    618

 tttatcagtt tcctgctttt tttaaaaatt aattttttaa ataaaagtaa tgtatgtata    678

 aatataaaat atcaaatctt actaaaagac ataatgaaaa gcagtaataa gctttgtttt    738

 gaattcagct aaatgcatag cgcttctgtg gaatgtatta ggcgatgaaa ttgctgtggt    798

 atcaaagttc ttatagaggc tgcattttta caggttgggc tgttaagtgc agctgaaatt    858

 gtgggttctt aacagaaata gcattttcaa gtattaaata ttaaactggt tagcaattct    918

 cctcgtgccg aattcc                                                    934




      <210> 483
      <211> 4352
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1011)

      <400> 483
  atg gcc ccc aaa ctc atc acc gtc ctg tgt ctg gga ttc tgc ctg aac      48
  Met Ala Pro Lys Leu Ile Thr Val Leu Cys Leu Gly Phe Cys Leu Asn
    1               5                  10                  15

 cag aag atc tgc cca cat gcg ggt gct cag gac aag ttc tcc ctg tca       96
 Gln Lys Ile Cys Pro His Ala Gly Ala Gln Asp Lys Phe Ser Leu Ser
              20                  25                  30

 gcc tgg ccg agc cct gtg gtt ccc cta gga gga cgt gtg act ctc tcc      144
 Ala Trp Pro Ser Pro Val Val Pro Leu Gly Gly Arg Val Thr Leu Ser
          35                  40                  45

 tgt cat tcc cat ctt cgg ttt gtc ata tgg aca ata ttc caa aca act      192
 Cys His Ser His Leu Arg Phe Val Ile Trp Thr Ile Phe Gln Thr Thr
      50                  55                  60

 ggg acc cga agc cat gag ttg cac act ggc ctt tcc aac aac atc acc      240
 Gly Thr Arg Ser His Glu Leu His Thr Gly Leu Ser Asn Asn Ile Thr
  65                  70                  75                  80

 atc agc cct gtg acc cca gaa cac gca ggg acc tac aga tgt gtt gga      288
 Ile Ser Pro Val Thr Pro Glu His Ala Gly Thr Tyr Arg Cys Val Gly
                  85                  90                  95

 att tac aag cac gcc tca aag tgg tca gct gag agc aac tcc ctg aag      336
 Ile Tyr Lys His Ala Ser Lys Trp Ser Ala Glu Ser Asn Ser Leu Lys
             100                 105                 110

 atc atc gtc aca ggc ttg ttc aca aaa ccc tcc atc tca gcg cac cca      384
 Ile Ile Val Thr Gly Leu Phe Thr Lys Pro Ser Ile Ser Ala His Pro
         115                 120                 125

 agc tcc ctg gtg cat gca gga gcc agg gtg agc ctg cgc tgt cac tca      432
 Ser Ser Leu Val His Ala Gly Ala Arg Val Ser Leu Arg Cys His Ser
     130                 135                 140

 gaa ctg gcc ttt gat gaa ttt atc tta tac aaa gag ggg cac ata cag      480
 Glu Leu Ala Phe Asp Glu Phe Ile Leu Tyr Lys Glu Gly His Ile Gln
 145                 150                 155                 160

 cat tcc cag cag ctt gac cag ggg atg gag gct ggg atc cat tac gtc      528
 His Ser Gln Gln Leu Asp Gln Gly Met Glu Ala Gly Ile His Tyr Val
                 165                 170                 175

 gag gct gtc ttt tcc atg ggt cct gta acg cct gcc cat gca gga gcc      576
 Glu Ala Val Phe Ser Met Gly Pro Val Thr Pro Ala His Ala Gly Ala
             180                 185                 190

 tac aga tgc tgt ggt tgt ttc agt cac tcc cgc tat gag tgg tcg gct      624
 Tyr Arg Cys Cys Gly Cys Phe Ser His Ser Arg Tyr Glu Trp Ser Ala
         195                 200                 205

 ccc agt gac ccc ctg gac att gtg atc aca gga aaa tac aaa aag cct      672
 Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Lys Tyr Lys Lys Pro
     210                 215                 220

 tct ctc tcc acc cag gtg gac ccc atg atg agg ctg gga gag aag ttg      720
 Ser Leu Ser Thr Gln Val Asp Pro Met Met Arg Leu Gly Glu Lys Leu
 225                 230                 235                 240

 acc ctc ttc tgc agc tct gaa atc tca ttt gac cag tac cat ctg ttc      768
 Thr Leu Phe Cys Ser Ser Glu Ile Ser Phe Asp Gln Tyr His Leu Phe
                 245                 250                 255

 aga cac ggg gtt gct cat gga cag tgg ctc agt gga ggg cag aga cac      816
 Arg His Gly Val Ala His Gly Gln Trp Leu Ser Gly Gly Gln Arg His
             260                 265                 270

 agg gaa gca ttc cag gcc aac ttt tct gtg ggc cgt gca acg cca gtc      864
 Arg Glu Ala Phe Gln Ala Asn Phe Ser Val Gly Arg Ala Thr Pro Val
         275                 280                 285

 cct ggc ggg acc tat aga tgc tat ggt tcc ttc aat gac tct ccc tat      912
 Pro Gly Gly Thr Tyr Arg Cys Tyr Gly Ser Phe Asn Asp Ser Pro Tyr
     290                 295                 300

 aag ccc cca gtg acc cgc tgc aac ttt aca cca cag gaa aca cta aga      960
 Lys Pro Pro Val Thr Arg Cys Asn Phe Thr Pro Gln Glu Thr Leu Arg
 305                 310                 315                 320

 gta ctc ctc tgt cat tca cag aat cca ccc ctg aat ctg gta agc aaa     1008
 Val Leu Leu Cys His Ser Gln Asn Pro Pro Leu Asn Leu Val Ser Lys
                 325                 330                 335

 taa ctct tatcctagtg tctgagtccc tggggagaca gaaggcccca gtgtgagtga     1065
 


 aagctgtgcc acctcccagc tccatgaccc tgggctaggc agcccctccc aggtccccac   1125

 attccccatc cacatctgag actgtggtca gtgcgggaat ctgtaaggcc tttcagcctc   1185

 agacgctttg ggactgaggc ctcatccaca ggggaggaag aggtcagagt cacctgaccc   1245

 ttgctgaaaa gcaatgcttc tcattcctcc agggaggtct gtgaacatga aaatgctgga   1305

 agatgggaag gatttaaaag accatattcg atattcactg tctgtctttt tttgttgttt   1365

 tttttttttg agacagagtc tcactctgtc gcccaggctg gagtgcggtg gcacaatctc   1425

 ggctcactgc aacctctgcc tcctgggttc aagcgatttt cctgcctcag cctcccgagt   1485

 agctgggatt acaggtgccc accaccacac ccggctaatt tttgtatttt tagtagagtc   1545

 agggtttcgc catgttgccc aggctggtgt caaactcctg acctcaagtg atctgtccgc   1605

 cttggcctcc caaggtgctg ggattacagg cgtgagccag tgtgcccggc ctccgttgag   1665

 gttcttgatg gagaaaccct gctccttccc ttcactgacc aatcacccca acccctcccc   1725

 tacctccacc tcacctctgg ggaggccact gacctgcagg agatggtcca tgagagaggc   1785

 agaaggatgg gggccatcta tcggagcggt cctggggcag tcaagattgc cccaaggttg   1845

 ctgatgggtg gttctctgaa tttagtgggg gaggctggat cacgctgcag cctcaggcac   1905

 gcccttgcct tgttttggtc ttggtattgc cacctctgaa gtgaagatct ggaagacttt   1965

 ctttttcacc ccacagacac caccatggca aacacagagc ccacggaagg ccaacggacg   2025

 gatgaagagg tgagttctcc cagccgaaac catcaccaca gcttcatccc ctcccattcc   2085

 cagtgcccct gccttcagcc actaaatatg ctcctctttt caccttcatc ctctcaggag   2145

 cctgcagcag aagagacaca ggagatcata tatgcccagt taaaccacca ggccctctca   2205

 cagacaggat tccctcctgc ctcccagtgt ccccactacc tctcggagga tcctagtatc   2265

 tacatcactg tccaccaagc ccaggctgag gccagagctg cccccagtct ttggcacaaa   2325

 gggcattaat acgcaaggac ctggatctat tcctaggagg attttttttc cacggacatt   2385

 cttcctcctt ctggtaccat cttgacacct cgaagctggc aacagcagtg tctgaatgct   2445

 tgtgggatta tcttaaaatt ccagcactgc tgaacagaca actagccatt ctacaattct   2505

 attttgagca tccaaccatt tcaggtgatt tgactctacc cacacactca tcctggatat   2565

 ctcattaata tcatctgagt tatcctgaaa ctctacagac atgcttctgg aaagccgatg   2625

 tatatgctca gccagtttaa tctctaaatt actcaataag gtttttttaa aaaaaatttt   2685

 tttaaagttc tggggtacat gctcaggatg tgcaggtttg ttacgtaggt aaacgtgtgc   2745

 catggtggtt tgctgcacct atcaaaccgt cacctaggta ttaagcccag caggcattag   2805

 ctctcttccc taatgctctc cataccccct gccctcctct gacaggcccc agtgaatgtg   2865

 ttcccctccc tgtgtccatg tgttctcatt gttcagctcc cacttataag tgaaaacatg   2925

 cggtgtctgg ttttctgttc ctgcattagt ttgctgagga taatgtcttc tagcttcatt   2985

 catgtctctg caaatgatat gatctcattc ctttttatga ctgcgtagta ttccgtggtg   3045

 tatatgtaca actttatttt tatccagtct atcattgatg ggcatttggg ttgattccac   3105

 gtctttgctg ttactcaaca aaattttgca gagatgaagt gtattctata tctgagtcat   3165

 ctaatatggt agccactagc caaatatggc tttttaactt agaattagaa tagatcaaat   3225

 tccatgaagt ttaaaattca gttcctcagc cacatggcca caatttgagt tctcagagcc   3285

 acgtgtggct gctggctgtg ggagagaata gcatgaacac aaaatgtttt ccttgtcaga   3345

 ggaagttcta gctgttctag attaaaggtg caaatttgaa gatgcagagc ctattttctc   3405

 atgcagtgca ggctcctgga agagacctaa tgtaacaaaa cgataatatt tcacatcaat   3465

 ggtgacatgt ctttatctta cgaaatgcgg ggaacaagca gagttctctt gtggagtgtc   3525

 ttatcacctc ttatcctcat gcaaatttct gccatagaga ttttctccca aactttgaga   3585

 aggtcacctc tgtcaggcct ctgagcccaa gctaagccat cctatcccct gtgacctgca   3645

 cgtacacatc cagatggcct gaagcaactg aagattcaca aaagaagtga aaatagcctt   3705

 agactgatga cattccacca ctgtgacttg ttcccgcccc actaactgat accatatatt   3765

 ctgccccgcc caagaaggta ctttgtaata ttcctcgccc ccgtaccccc caccgccctg   3825

 cccccgctcg cccgccatta agaaggtact ttgtaatatt ctcccgccac aactttagaa   3885

 ggtactttgt aatattctcc cccacaactt tagaaggtac tttgtaatat tctcccccac   3945

 aactttagaa ggtactttgt aatattctcc cctcccctta agaaggtact ttgtaatatt   4005

 ctcccccaca actttagaag gtactttgta atattctccc ctccccttaa gaaggtactt   4065

 cgaggctggg tgcggtggct catgtctgta atcccagcac tctggggggc cgaggtgggt   4125

 ggatcacgag gtcaggagat cgagaccatc ctggctaatg tggtgaaacc ccgtctctac   4185

 taaaaaaata caaaacaatt agctgggcat ggtggcgggt gcctgtagtc ccagccactt   4245

 gggagtctga ggcaggagaa tggcgtgaac ccaggaggca gagcttgcag tgagctgaga   4305

 tcgcgccact gcactccagc ctgggcgata gagcaagact ctgtctc                 4352




      <210> 484
      <211> 5627
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (112)..(2865)

      <400> 484
 taagcttgcg gccgcgagcg agaggaggag ctccagtggc ggcggcggcg gcggcagcgg     60

 cagcgggcag cagctccagc agcgccagca ggcgggatcg aggccgtcaa c atg gcg     117
                                                          Met Ala
                                                            1

 agc gcc tcg tac cac att tcc aat ttg ctg gaa aaa atg aca tcc agc      165
 Ser Ala Ser Tyr His Ile Ser Asn Leu Leu Glu Lys Met Thr Ser Ser
           5                  10                  15

 gac aag gac ttt agg ttt atg gct aca aat gat ttg atg acg gaa ctg      213
 Asp Lys Asp Phe Arg Phe Met Ala Thr Asn Asp Leu Met Thr Glu Leu
      20                  25                  30

 cag aaa gat tcc atc aag ttg gat gat gat agt gaa agg aaa gta gtg      261
 Gln Lys Asp Ser Ile Lys Leu Asp Asp Asp Ser Glu Arg Lys Val Val
  35                  40                  45                  50

 aaa atg att ttg aag tta ttg gaa gat aaa aat gga gag gta cag aat      309
 Lys Met Ile Leu Lys Leu Leu Glu Asp Lys Asn Gly Glu Val Gln Asn
                  55                  60                  65

 tta gct gtc aaa tgt ctt ggt cct tta gtg agt aaa gtg aaa gaa tac      357
 Leu Ala Val Lys Cys Leu Gly Pro Leu Val Ser Lys Val Lys Glu Tyr
              70                  75                  80

 caa gta gag aca att gta gat acc ctc tgc act aac atg ctt tct gat      405
 Gln Val Glu Thr Ile Val Asp Thr Leu Cys Thr Asn Met Leu Ser Asp
          85                  90                  95

 aaa gaa caa ctt cga gac att tca agt att ggt ctt aaa aca gta att      453
 Lys Glu Gln Leu Arg Asp Ile Ser Ser Ile Gly Leu Lys Thr Val Ile
     100                 105                 110

 gga gaa ctt cct cca gct tcc agt ggc tct gca tta gct gct aat gta      501
 Gly Glu Leu Pro Pro Ala Ser Ser Gly Ser Ala Leu Ala Ala Asn Val
 115                 120                 125                 130

 tgt aaa aag att act gga cgt ctt aca agt gca ata gca aaa cag gaa      549
 Cys Lys Lys Ile Thr Gly Arg Leu Thr Ser Ala Ile Ala Lys Gln Glu
                 135                 140                 145

 gat gtc tct gtt cag cta gaa gcc ttg gat att atg gct gat atg ttg      597
 Asp Val Ser Val Gln Leu Glu Ala Leu Asp Ile Met Ala Asp Met Leu
             150                 155                 160

 agc agg caa gga gga ctt ctt gtt aat ttc cat cct tca att ctg acc      645
 Ser Arg Gln Gly Gly Leu Leu Val Asn Phe His Pro Ser Ile Leu Thr
         165                 170                 175

 tgt cta ctt ccc cag ttg acc agc cct aga ctt gca gtg agg aaa aga      693
 Cys Leu Leu Pro Gln Leu Thr Ser Pro Arg Leu Ala Val Arg Lys Arg
     180                 185                 190

 acc att atc gct ctt ggc cat ctg gtt atg agc tgt gga aat ata gtt      741
 Thr Ile Ile Ala Leu Gly His Leu Val Met Ser Cys Gly Asn Ile Val
 195                 200                 205                 210

 ttt gta gat ctt att gaa cat ctg ttg tca gag ttg tcc aaa aat gat      789
 Phe Val Asp Leu Ile Glu His Leu Leu Ser Glu Leu Ser Lys Asn Asp
                 215                 220                 225

 tct atg tca aca aca aga acc tac ata caa tgt att gct gct att agt      837
 Ser Met Ser Thr Thr Arg Thr Tyr Ile Gln Cys Ile Ala Ala Ile Ser
             230                 235                 240

 agg caa gct ggt cat aga ata ggt gaa tac ctt gag aag ata att cct      885
 Arg Gln Ala Gly His Arg Ile Gly Glu Tyr Leu Glu Lys Ile Ile Pro
         245                 250                 255

 ttg gtg gta aaa ttt tgc aat gta gat gat gat gaa tta aga gag tac      933
 Leu Val Val Lys Phe Cys Asn Val Asp Asp Asp Glu Leu Arg Glu Tyr
     260                 265                 270

 tgt att caa gcc ttt gaa tca ttt gta aga aga tgt cct aag gaa gta      981
 Cys Ile Gln Ala Phe Glu Ser Phe Val Arg Arg Cys Pro Lys Glu Val
 275                 280                 285                 290

 tat cct cat gtt tct acc att ata aat att tgt ctt aaa tat ctt acc     1029
 Tyr Pro His Val Ser Thr Ile Ile Asn Ile Cys Leu Lys Tyr Leu Thr
                 295                 300                 305

 tat gat cca aat tat aat tac gat gat gaa gat gaa gat gaa aat gca     1077
 Tyr Asp Pro Asn Tyr Asn Tyr Asp Asp Glu Asp Glu Asp Glu Asn Ala
             310                 315                 320

 atg gat gct gat ggt ggt gat gat gat gat caa ggg agt gat gat gaa     1125
 Met Asp Ala Asp Gly Gly Asp Asp Asp Asp Gln Gly Ser Asp Asp Glu
         325                 330                 335

 tac agt gat gat aat gac atg agc tgg aaa gtg aga cgt gca gct gcg     1173
 Tyr Ser Asp Asp Asn Asp Met Ser Trp Lys Val Arg Arg Ala Ala Ala
     340                 345                 350

 aag tgc ttg gat gct gta gtt agc aca agg cat gaa atg ctt cca gaa     1221
 Lys Cys Leu Asp Ala Val Val Ser Thr Arg His Glu Met Leu Pro Glu
 355                 360                 365                 370

 ttc tac aag acc gtc tct cct gca cta ata tcc aga ttt aaa gag cgt     1269
 Phe Tyr Lys Thr Val Ser Pro Ala Leu Ile Ser Arg Phe Lys Glu Arg
                 375                 380                 385

 gaa gag aat gta aag gca gat gtt ttt cac gca tac ctt tct ctt ttg     1317
 Glu Glu Asn Val Lys Ala Asp Val Phe His Ala Tyr Leu Ser Leu Leu
             390                 395                 400

 aag caa act cgt cct gta caa agt tgg cta tgt gac cct gat gca atg     1365
 Lys Gln Thr Arg Pro Val Gln Ser Trp Leu Cys Asp Pro Asp Ala Met
         405                 410                 415

 gag cag gga gaa aca cct tta aca atg ctt cag agt cag gtt ccc aac     1413
 Glu Gln Gly Glu Thr Pro Leu Thr Met Leu Gln Ser Gln Val Pro Asn
     420                 425                 430

 att gtt aaa gct ctt cac aaa cag atg aaa gaa aaa agt gtg aag acc     1461
 Ile Val Lys Ala Leu His Lys Gln Met Lys Glu Lys Ser Val Lys Thr
 435                 440                 445                 450

 cga cag tgt tgt ttt aac atg tta act gag ctg gta aat gta tta cct     1509
 Arg Gln Cys Cys Phe Asn Met Leu Thr Glu Leu Val Asn Val Leu Pro
                 455                 460                 465

 ggg gcc cta act caa cac att cct gta ctt gta cca gga atc att ttc     1557
 Gly Ala Leu Thr Gln His Ile Pro Val Leu Val Pro Gly Ile Ile Phe
             470                 475                 480

 tca ctg aat gat aaa tca agc tca tcg aat ttg aag atc gat gct ttg     1605
 Ser Leu Asn Asp Lys Ser Ser Ser Ser Asn Leu Lys Ile Asp Ala Leu
         485                 490                 495

 tca tgt cta tac gta atc ctc tgt aac cat tct cct caa gtc ttc cat     1653
 Ser Cys Leu Tyr Val Ile Leu Cys Asn His Ser Pro Gln Val Phe His
     500                 505                 510

 cct cac gtt cag gct ttg gtt cct cca gtg gtg gct tgt gtt gga gac     1701
 Pro His Val Gln Ala Leu Val Pro Pro Val Val Ala Cys Val Gly Asp
 515                 520                 525                 530

 cca ttt tac aaa att aca tct gaa gca ctt ctt gtt act caa cag ctt     1749
 Pro Phe Tyr Lys Ile Thr Ser Glu Ala Leu Leu Val Thr Gln Gln Leu
                 535                 540                 545

 gtc aaa gta att cgt cct tta gat cag cct tcc tcg ttt gat gca act     1797
 Val Lys Val Ile Arg Pro Leu Asp Gln Pro Ser Ser Phe Asp Ala Thr
             550                 555                 560

 cct tat atc aaa gat cta ttt acc tgt acc att aag aga tta aaa gca     1845
 Pro Tyr Ile Lys Asp Leu Phe Thr Cys Thr Ile Lys Arg Leu Lys Ala
         565                 570                 575

 gct gac att gat cag gaa gtc aag gaa agg gct att tcc tgt atg gga     1893
 Ala Asp Ile Asp Gln Glu Val Lys Glu Arg Ala Ile Ser Cys Met Gly
     580                 585                 590

 caa att att tgc aac ctt gga gac aat ttg ggt tct gac ttg cct aat     1941
 Gln Ile Ile Cys Asn Leu Gly Asp Asn Leu Gly Ser Asp Leu Pro Asn
 595                 600                 605                 610

 aca ctt cag att ttc ttg gag aga cta aag aat gaa att acc agg tta     1989
 Thr Leu Gln Ile Phe Leu Glu Arg Leu Lys Asn Glu Ile Thr Arg Leu
                 615                 620                 625

 act aca gta aag gca ttg aca ctg att gct ggg tca cct ttg aag ata     2037
 Thr Thr Val Lys Ala Leu Thr Leu Ile Ala Gly Ser Pro Leu Lys Ile
             630                 635                 640

 gat ttg agg cct gtt ctg gga gaa ggg gtt cct atc ctt gct tca ttt     2085
 Asp Leu Arg Pro Val Leu Gly Glu Gly Val Pro Ile Leu Ala Ser Phe
         645                 650                 655

 ctt aga aaa aac cag aga gct ttg aaa ctg ggt act ctt tct gcc ctt     2133
 Leu Arg Lys Asn Gln Arg Ala Leu Lys Leu Gly Thr Leu Ser Ala Leu
     660                 665                 670

 gat att cta ata aaa aac tat agt gac agc ttg aca gct gcc atg att     2181
 Asp Ile Leu Ile Lys Asn Tyr Ser Asp Ser Leu Thr Ala Ala Met Ile
 675                 680                 685                 690

 gat gca gtt cta gat gag ctc cca cct ctt atc agc gaa agt gat atg     2229
 Asp Ala Val Leu Asp Glu Leu Pro Pro Leu Ile Ser Glu Ser Asp Met
                 695                 700                 705

 cat gtt tca caa atg gcc atc agt ttt ctt acc act ttg gca aaa gta     2277
 His Val Ser Gln Met Ala Ile Ser Phe Leu Thr Thr Leu Ala Lys Val
             710                 715                 720

 tat ccc tcc tcc ctt tca aag ata agt gga tcc att ctc aat gaa ctt     2325
 Tyr Pro Ser Ser Leu Ser Lys Ile Ser Gly Ser Ile Leu Asn Glu Leu
         725                 730                 735

 att gga ctt gtg aga tca ccc tta ttg cag ggg gga gct ctt agt gcc     2373
 Ile Gly Leu Val Arg Ser Pro Leu Leu Gln Gly Gly Ala Leu Ser Ala
     740                 745                 750

 atg cta gac ttt ttc caa gct ctg gtt gtc act gga aca aat aat tta     2421
 Met Leu Asp Phe Phe Gln Ala Leu Val Val Thr Gly Thr Asn Asn Leu
 755                 760                 765                 770

 gga tac atg gat ttg ttg cgc atg ctg act ggt cca gtt tac tct cag     2469
 Gly Tyr Met Asp Leu Leu Arg Met Leu Thr Gly Pro Val Tyr Ser Gln
                 775                 780                 785

 agc aca gct ctt act cat aag cag tct tat tat tcc att gcc aaa tgt     2517
 Ser Thr Ala Leu Thr His Lys Gln Ser Tyr Tyr Ser Ile Ala Lys Cys
             790                 795                 800

 gta gct gcc ctt act cga gca tgc cct aaa gag gga cca gct gta gta     2565
 Val Ala Ala Leu Thr Arg Ala Cys Pro Lys Glu Gly Pro Ala Val Val
         805                 810                 815

 ggt cag ttt att caa gat gtc aag aac tca agg tct aca gat tcc att     2613
 Gly Gln Phe Ile Gln Asp Val Lys Asn Ser Arg Ser Thr Asp Ser Ile
     820                 825                 830

 cgt ctc tta gct cta ctt tct ctt gga gaa gtt ggg cat cat att gac     2661
 Arg Leu Leu Ala Leu Leu Ser Leu Gly Glu Val Gly His His Ile Asp
 835                 840                 845                 850

 tta agt gga cag ttg gaa cta aaa tct gta ata cta gaa gct ttc tca     2709
 Leu Ser Gly Gln Leu Glu Leu Lys Ser Val Ile Leu Glu Ala Phe Ser
                 855                 860                 865

 tct cct agt gaa gaa gtc aaa tca gct gca tcc tat gca tta ggc agc     2757
 Ser Pro Ser Glu Glu Val Lys Ser Ala Ala Ser Tyr Ala Leu Gly Ser
             870                 875                 880

 att agt gtg ggc aac ctt cct gaa tat cta ccc ttt gtc ctg caa gaa     2805
 Ile Ser Val Gly Asn Leu Pro Glu Tyr Leu Pro Phe Val Leu Gln Glu
         885                 890                 895

 ata act agt caa ccc aaa agg cag tat cta ttt act tca ttc ctt gaa     2853
 Ile Thr Ser Gln Pro Lys Arg Gln Tyr Leu Phe Thr Ser Phe Leu Glu
     900                 905                 910

 gga aat tat tag ctc tgcatcagtg gtgggcctta aaccatatgt tgaaaacatc     2908
 Gly Asn Tyr 
 915

 tgggccttat tactaaagca ctgtgagtgt gcagaggaag gaaccagaaa tgttgttgct   2968

 gaatgtctag gaaaactcac tctaattgat ccagaaactc tccttccacg gcttaagggg   3028

 tacttgatat caggctcatc atatgcccga agctcagtgg ttacggctgt gaaatttaca   3088

 atttctgacc atccacaacc tattgatcca ctgttaaaga actgcatagg tgatttccta   3148

 aaaactttgg aagacccaga tttgaatgtg agaagagtag ccttggtcac atttatttca   3208

 gcagcacata acaagccatc attaataagg gatctattgg atactgttct tccacatctt   3268

 tacaatgaaa ctaaaagtta gaaaggagct tataagagag gtagaaatgg gtccatttaa   3328

 acatacggtt gatgatggtc tggatattag aaaggcagca tttgagtgta tgtacacact   3388

 tctagacagt tgtcttgata gacttgatat ctttgaattt ctaaatcatg ttgaagatgg   3448

 tttgaaggac cattatgata ttaagatgct gacattttta atgttggtga gactgtctac   3508

 cctttgtcca agtgcagtac tgcagaggtt ggaccgactt gttgagccat tacgtgcaac   3568

 atgtacaact aaggtaaagg caaactcagt aaagcaggag tttgaaaaac aagatgaatt   3628

 aaagcgatct gccatgagag cagtagcagc actactaacc attccagaag cagagaagag   3688

 tccactgatg agtgaattcc agtcacagat cagttctaac cctgagctgg cggctatctt   3748

 tgaaagtatc cagaaagatt catcatctac taacttggaa tcaatggaca ctagttagat   3808

 gtttgttcac catggggacc attacatatg accatacaat gcactgaatt gacaggttaa   3868

 tcataagaca tggaaagaga agtgtctaaa agcttcaaaa tgttccactt ttttttcctt   3928

 catggagact gtttgtttgg ctttcttcca ttgttgtttt tgtagcattt atttcagaaa   3988

 tgtgtatttc cataatccag aggttgtaaa accactagtg ttttagtggt tacagcaaca   4048

 tttgaaatgg aaactaaaag ttaggatttt atggagtatg gagatagggt ccagtatcta   4108

 tttaccctgt aatgtttagg attaaaatgt taaaattttg tgaccatgaa tttctttctt   4168

 ttataaattt tctcatttaa aaatcaaaaa tcttgcaaaa caaaaaccat gtttcttttt   4228

 cttgtataac tttttgtttt cagcaacata aattgatttt tagctggcag acaagaatat   4288

 ccatataaga tttgttaacc atttcagaga gtttggcaat ttttaaaaga taataaggta   4348

 tcatttttaa gtatgaaaat taacaatatc cctgttgcgc acactaattt tgcatgagta   4408

 agtttacaaa tatgtatcgt ctgtaaagca gcatgtgcag attattcata atatagaagt   4468

 taaaataagt attagtgcaa ttttcagata tttatttttg cacagaaaac acattatctg   4528

 gagagaaaga aaggagaatt tttgagactt gggttttctt aatgccagtg tgaatttgca   4588

 gatgttttca gaaaatcaag tcacagtaac aatttgccac ttttttctat tataaatctt   4648

 cttacttaaa ttttgaatat ttagtttttc tcagttaccc atttgtgtgt gtgtgattcc   4708

 acttagaaat tcttaaaacc agatttttct ttcattccgt ttggatgtct acattcctta   4768

 tcaaaggata taaatactgt gtatgctttt gaattttatt tttaggaaaa ttctgaagcc   4828

 agctatcaca ggtttgttag ctaataatag tattttcttt tagttgagtt aggtttttcc   4888

 ccatctcctg tagagcgaat ttacatattg tattgggtaa gtgttcacta cttttcctga   4948

 ttaagggatc tgtgctgggg aacaaagctt ttgcagtacc ttatattgta gttaaaattt   5008

 tatttaacat atccttcagt gagctcattt cacactgtag cctcttcctt aaaatttgtg   5068

 gtgctcctgt aacagtaaga actaattctg aaataaaaga catctcctaa tgctgtgcaa   5128

 acatagttta catgtattga aggaggcagt tgttaaattg agtgaccaat ttaagcaatc   5188

 agatatttga aaactgcacc ctttagtttt gaaactgtga attagaaaca cttttcctgc   5248

 tgtattacta cctgctttaa catccaaata tacagtgatt ttaaatgata acatactgtg   5308

 gttattagat taacagcttg attttgaatg ttcagatgat aatgcagaag acatcacttc   5368

 tagtaaggat tttgactagt gcattgatgt tgaagttggt gccatttcaa aatgtggcag   5428

 gtgataatct tttaccataa tttgcataaa actgtaatag aagtttattt tgagatgtta   5488

 gtatattatg tactatgcat ttctgtggta tagatgttgt ggatatattt aagtatttgg   5548

 ttacatggtt ttacaataaa ttacaatact gcaggctcta ggactgaaca ggagactgac   5608

 atgcaaaaaa aaaaaaaaa                                                5627




      <210> 485
      <211> 949
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (123)..(818)

      <400> 485
 ttcctgagat accgctccgg aattcccggg tcgacccacg cgtccgccca cgcgtccgat     60

 ttcatgttat acttaataaa acaaaacata cctgtataca cacacattca ctcacattga    120

 ag   atg caa gat gaa gaa aga tac atg aca ttg aat gta cag tca aag     167
      Met Gln Asp Glu Glu Arg Tyr Met Thr Leu Asn Val Gln Ser Lys
        1               5                  10                  15

 aaa agg agt tct gcc caa aca tct caa ctt aca ttt aaa gat tat tca      215
 Lys Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr Ser
                  20                  25                  30

 gtg acg ttg cat tgg tat aaa atc tta ctg gga ata tct gga acc gtg      263
 Val Thr Leu His Trp Tyr Lys Ile Leu Leu Gly Ile Ser Gly Thr Val
              35                  40                  45

 aat ggt att ctc act ttg act ttg atc tcc ttg atc ctg ttg gtt tct      311
 Asn Gly Ile Leu Thr Leu Thr Leu Ile Ser Leu Ile Leu Leu Val Ser
          50                  55                  60

 cag gga gta ttg cta aaa tgc caa aaa gga agt tgt tca aat gcc act      359
 Gln Gly Val Leu Leu Lys Cys Gln Lys Gly Ser Cys Ser Asn Ala Thr
      65                  70                  75

 cag tat gag gac act gga gat cta aaa gtg aat aat ggc aca aga aga      407
 Gln Tyr Glu Asp Thr Gly Asp Leu Lys Val Asn Asn Gly Thr Arg Arg
  80                  85                  90                  95

 aat ata agt aat aag gac ctt tgt gct tcg aga tct gca gac cag aca      455
 Asn Ile Ser Asn Lys Asp Leu Cys Ala Ser Arg Ser Ala Asp Gln Thr
                 100                 105                 110

 gta cta tgc caa tca gaa tgg ctc aaa tac caa ggg aag tgt tat tgg      503
 Val Leu Cys Gln Ser Glu Trp Leu Lys Tyr Gln Gly Lys Cys Tyr Trp
             115                 120                 125

 ttc tct aat gag atg aaa agc tgg agt gac agt tat gtg tat tgt ttg      551
 Phe Ser Asn Glu Met Lys Ser Trp Ser Asp Ser Tyr Val Tyr Cys Leu
         130                 135                 140

 gaa aga aaa tct cat cta cta atc ata cat gac caa ctt gaa atg gct      599
 Glu Arg Lys Ser His Leu Leu Ile Ile His Asp Gln Leu Glu Met Ala
     145                 150                 155

 ttt ata cag aaa aac cta aga caa tta aac tac gta tgg att ggg ctt      647
 Phe Ile Gln Lys Asn Leu Arg Gln Leu Asn Tyr Val Trp Ile Gly Leu
 160                 165                 170                 175

 aac ttt acc tcc ttg aaa atg aca tgg act tgg gtg gat ggt tct cca      695
 Asn Phe Thr Ser Leu Lys Met Thr Trp Thr Trp Val Asp Gly Ser Pro
                 180                 185                 190

 ata gat tca aag ata ttc ttc ata aag gga cca gct aaa gaa aac agc      743
 Ile Asp Ser Lys Ile Phe Phe Ile Lys Gly Pro Ala Lys Glu Asn Ser
             195                 200                 205

 tgt gct gcc att aag gaa agc aaa att ttc tct gaa acc tgc agc agt      791
 Cys Ala Ala Ile Lys Glu Ser Lys Ile Phe Ser Glu Thr Cys Ser Ser
         210                 215                 220

 gtt ttc aaa tgg att tgt cag tat tag agttt gacaaaattc acagtgaaat      843
 Val Phe Lys Trp Ile Cys Gln Tyr 
     225                 230

 aatcaatgat cactattttt ggcctattag tttctaatat taatctccag gtgttagagt    903

 tttaaagtgc gattgaatgc caaaatctct tctcccttct ctctcc                   949




      <210> 486
      <211> 556
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(489)

      <400> 486
 tagccttcag gaatgtttcc tcttttctgt ggggttacct ttgggttatc ttctctatta     60

 agtgtggatc cctgaaaaat ggcataccct ggtggttttt ctagcccctg ctgaaatcct    120

 ttgaaggaat gtacttattt gtcaagattc gtctaaaaat gtggtctcca gaaatgaaca    180

 tag  atg tgc tgt gag ctc ctt gca gtt gtg att gcg aca ctg ata att     228
      Met Cys Cys Glu Leu Leu Ala Val Val Ile Ala Thr Leu Ile Ile
        1               5                  10                  15

 aag att ggt tta gtt gtt ctg ttg tac ttc atc aaa ttg ttg att cac      276
 Lys Ile Gly Leu Val Val Leu Leu Tyr Phe Ile Lys Leu Leu Ile His
                  20                  25                  30

 att gaa ttt atc aaa cgt cat tct att cta aaa tgt gaa agt att ttt      324
 Ile Glu Phe Ile Lys Arg His Ser Ile Leu Lys Cys Glu Ser Ile Phe
              35                  40                  45

 aac tta aat gta gga att cgc atg tat cca gga caa gta aat ttt tgt      372
 Asn Leu Asn Val Gly Ile Arg Met Tyr Pro Gly Gln Val Asn Phe Cys
          50                  55                  60

 gaa aca ttg cag atg tta gat gga ttt ggg aga att ttc caa act aag      420
 Glu Thr Leu Gln Met Leu Asp Gly Phe Gly Arg Ile Phe Gln Thr Lys
      65                  70                  75

 tgg acg aac tta tat agc tac ata aat agt aac ttc ctg agg gca aca      468
 Trp Thr Asn Leu Tyr Ser Tyr Ile Asn Ser Asn Phe Leu Arg Ala Thr
  80                  85                  90                  95

 gac aaa cta ttt gat agc tga at acatatttga ttttaccaga tgttgcaaga      521
 Asp Lys Leu Phe Asp Ser 
                 100

 actctggagt tcttatggta ttaaaatgcc ggaaa                               556




      <210> 487
      <211> 5783
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (647)..(2380)

      <400> 487
 gtgaggaggg ccggcggcgg ggcggacccc tggcggtcct cctggctggg gtccgcgcgc     60

 tcgcggcagc tccccgtgga ggtcactgtc cgtgccagtc cctcccgctg tcccgccctc    120

 tcccgctgcc gccgccgccg ccgccgcgcc cgcctcagcg cccccactcc gcgcttggga    180

 gcgaggagcc gccagcgccc ccgccccgcc gccgccgcag cgccctcagg ccgccattcg    240

 ccaccgaaac tttccagcgc ccgcgctctc tccgggactc ggcggcggcg gggcgggggc    300

 ggcccggggg cggcgcgcgg ctgctccggg gcgccgggcc ctcttcggcc gccgcacggc    360

 cgggactcgg aggctgccgg ctggagggag gttcggagcg cggccgggcg cgcggcgccg    420

 ccacaagttg cgctgctcgc gacgagattt ccgtgagggt ggaagaaaat cataccatat    480

 cagatgcctc gcagagcacc aggcccaccg tgaaaggctg gtccctgcag acggcttccc    540

 atttttatga ccggatgctg ggaagcctgc tggtccacag gtccatacat gaagtcacca    600

 taaggagccc tggcctcctt gcagaaacat cgaggtgaca tgtagc   atg acc gag     655
                                                      Met Thr Glu
                                                        1

 ctc gct ggc gcc tct tca tcg tgc tgc cac cgc cct gca gga aga ggg      703
 Leu Ala Gly Ala Ser Ser Ser Cys Cys His Arg Pro Ala Gly Arg Gly
       5                  10                  15

 gcc atg cag tca gtc ttg cac cac ttt caa cgt ttg cga ggg aga gag      751
 Ala Met Gln Ser Val Leu His His Phe Gln Arg Leu Arg Gly Arg Glu
  20                  25                  30                  35

 ggt ggt tcc cac ttc atc aac acc tca tcg ccg cga ggt gag gct aag      799
 Gly Gly Ser His Phe Ile Asn Thr Ser Ser Pro Arg Gly Glu Ala Lys
                  40                  45                  50

 atg agc ata acc agt gac gag gtg aac ttt ctg gtg tat cgg tat ctc      847
 Met Ser Ile Thr Ser Asp Glu Val Asn Phe Leu Val Tyr Arg Tyr Leu
              55                  60                  65

 cag gag tca ggt ttt tcc cac tcg gct ttc acg ttt ggg att gag agc      895
 Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly Ile Glu Ser
          70                  75                  80

 cac atc agc cag tcc aac atc aat ggg acg cta gtg cca ccg gcc gcc      943
 His Ile Ser Gln Ser Asn Ile Asn Gly Thr Leu Val Pro Pro Ala Ala
      85                  90                  95

 ctc atc tcc att ctc cag aag ggc ctg cag tat gta gag gcc gag atc      991
 Leu Ile Ser Ile Leu Gln Lys Gly Leu Gln Tyr Val Glu Ala Glu Ile
 100                 105                 110                 115

 agt atc aac gag gat ggc aca gtg ttc gac ggc cgc ccc ata gag tcc     1039
 Ser Ile Asn Glu Asp Gly Thr Val Phe Asp Gly Arg Pro Ile Glu Ser
                 120                 125                 130

 ctg tca ctg ata gac gcc gtg atg ccc gac gtg gtg cag acg cgg cag     1087
 Leu Ser Leu Ile Asp Ala Val Met Pro Asp Val Val Gln Thr Arg Gln
             135                 140                 145

 cag gca ttc cga gag aag ctc gct cag cag caa gcc agt gcg gcg gcg     1135
 Gln Ala Phe Arg Glu Lys Leu Ala Gln Gln Gln Ala Ser Ala Ala Ala
         150                 155                 160

 gcg gcg gct gcg gcc acg gca gca gcg aca gca gcc acc acg acc tca     1183
 Ala Ala Ala Ala Ala Thr Ala Ala Ala Thr Ala Ala Thr Thr Thr Ser
     165                 170                 175

 gcc ggc gtt tcc cac caa aat cca tcg aag aac aga gag gcc acg gtg     1231
 Ala Gly Val Ser His Gln Asn Pro Ser Lys Asn Arg Glu Ala Thr Val
 180                 185                 190                 195

 aat ggg gaa gag aac aga gca cat tca gtc aat aat cac gcg aag cca     1279
 Asn Gly Glu Glu Asn Arg Ala His Ser Val Asn Asn His Ala Lys Pro
                 200                 205                 210

 atg gaa ata gat gga gag gtt gag att cca tcc agc aaa gcc aca gtc     1327
 Met Glu Ile Asp Gly Glu Val Glu Ile Pro Ser Ser Lys Ala Thr Val
             215                 220                 225

 ctt cgg ggc cat gag tct gag gtg ttc att tgt gcc tgg aat cct gtc     1375
 Leu Arg Gly His Glu Ser Glu Val Phe Ile Cys Ala Trp Asn Pro Val
         230                 235                 240

 agt gat ttg cta gcc tcc gga tct gga gac tca act gca agg ata tgg     1423
 Ser Asp Leu Leu Ala Ser Gly Ser Gly Asp Ser Thr Ala Arg Ile Trp
     245                 250                 255

 aac ctg aat gag aat agc aac ggg ggc tcc acc cag ctc gtg ttg agg     1471
 Asn Leu Asn Glu Asn Ser Asn Gly Gly Ser Thr Gln Leu Val Leu Arg
 260                 265                 270                 275

 cac tgt ata cga gag ggg ggc cat gac gtc ccg agt aac aaa gac gtc     1519
 His Cys Ile Arg Glu Gly Gly His Asp Val Pro Ser Asn Lys Asp Val
                 280                 285                 290

 acc tca ctg gac tgg aat acc aat gga aca ctc ttg gct acg ggt tca     1567
 Thr Ser Leu Asp Trp Asn Thr Asn Gly Thr Leu Leu Ala Thr Gly Ser
             295                 300                 305

 tat gac ggt ttt gca aga ata tgg acg gaa gat ggt aac ctg gcc agc     1615
 Tyr Asp Gly Phe Ala Arg Ile Trp Thr Glu Asp Gly Asn Leu Ala Ser
         310                 315                 320

 acc tta ggc caa cat aaa ggc ccc atc ttt gcc ttg aaa tgg aac cga     1663
 Thr Leu Gly Gln His Lys Gly Pro Ile Phe Ala Leu Lys Trp Asn Arg
     325                 330                 335

 aag ggg aat tac att ttg agt gct ggt gta gac aaa aca aca ata att     1711
 Lys Gly Asn Tyr Ile Leu Ser Ala Gly Val Asp Lys Thr Thr Ile Ile
 340                 345                 350                 355

 tgg gat gcc cac aca gga gaa gcc aaa cag cag ttt cct ttt cat tca     1759
 Trp Asp Ala His Thr Gly Glu Ala Lys Gln Gln Phe Pro Phe His Ser
                 360                 365                 370

 gcc cct gcc ctt gat gtg gac tgg cag aac aac acg acc ttt gcc tcc     1807
 Ala Pro Ala Leu Asp Val Asp Trp Gln Asn Asn Thr Thr Phe Ala Ser
             375                 380                 385

 tgt agc aca gac atg tgt atc cat gtg tgc agg ctc ggc tgt gac cgc     1855
 Cys Ser Thr Asp Met Cys Ile His Val Cys Arg Leu Gly Cys Asp Arg
         390                 395                 400

 cca gtc aaa acc ttc cag gga cac aca aac gag gtc aac gcc atc aaa     1903
 Pro Val Lys Thr Phe Gln Gly His Thr Asn Glu Val Asn Ala Ile Lys
     405                 410                 415

 tgg gat ccg tct gga atg ttg ctg gca tcc tgc tcg gat gac atg aca     1951
 Trp Asp Pro Ser Gly Met Leu Leu Ala Ser Cys Ser Asp Asp Met Thr
 420                 425                 430                 435

 ttg aag atc tgg agc atg aaa cag gag gtg tgc atc cat gat ctt cag     1999
 Leu Lys Ile Trp Ser Met Lys Gln Glu Val Cys Ile His Asp Leu Gln
                 440                 445                 450

 gct cac aat aaa gag atc tac acc atc aag tgg agc ccc act ggg ccc     2047
 Ala His Asn Lys Glu Ile Tyr Thr Ile Lys Trp Ser Pro Thr Gly Pro
             455                 460                 465

 gcc acc agc aac cca aac tcc aac atc atg ttg gca agt gct tcg ttt     2095
 Ala Thr Ser Asn Pro Asn Ser Asn Ile Met Leu Ala Ser Ala Ser Phe
         470                 475                 480

 gat tct acg gtg cga ctg tgg gac ata gaa cga ggc gtc tgc acc cac     2143
 Asp Ser Thr Val Arg Leu Trp Asp Ile Glu Arg Gly Val Cys Thr His
     485                 490                 495

 acg ctc acg aag cat cag gag cct gtc tat agc gta gct ttc agc cct     2191
 Thr Leu Thr Lys His Gln Glu Pro Val Tyr Ser Val Ala Phe Ser Pro
 500                 505                 510                 515

 gat ggg aag tac ttg gcc agt gga tcc ttc gac aag tgc gtc cat atc     2239
 Asp Gly Lys Tyr Leu Ala Ser Gly Ser Phe Asp Lys Cys Val His Ile
                 520                 525                 530

 tgg aat act cag agt gga aat ctt gtc cac agc tac cga ggc act ggc     2287
 Trp Asn Thr Gln Ser Gly Asn Leu Val His Ser Tyr Arg Gly Thr Gly
             535                 540                 545

 ggc atc ttc gag gtg tgc tgg aac gcc cga gga gac aaa gtg ggt gcc     2335
 Gly Ile Phe Glu Val Cys Trp Asn Ala Arg Gly Asp Lys Val Gly Ala
         550                 555                 560

 agc gcg tcc gac ggc tct gtg tgt gtt ttg gat ctg cgg aag taa cca     2383
 Ser Ala Ser Asp Gly Ser Val Cys Val Leu Asp Leu Arg Lys 
     565                 570                 575

 caaaatatta tcgaaaaaaa aaaagaattc taatgaccag ccgtgaatgt gtagggttgc   2443

 agctctattc tccaaaactg taggaacttg acttgcgtta gagtgtactc tgaaaccaac   2503

 tcgtctctgg ccgcaggagt ctatatgttt tcgtaatctt catcaagaag tttttaaaag   2563

 gcaagcaaaa acagaagcaa atcatatcaa acggggatag aatggtttcc actgaggaca   2623

 ttcagcctgg gaaggaggaa gtcaccagct cgaggcgtgt ggattggttt ccacccggaa   2683

 caggctctgt gatggctgaa tggaaagaaa cgtaaaaagc tgtgccaaaa aaaaagcaaa   2743

 atgctgtgat aaaccaaaca gggaaggggg aaaaaccctc ctccttggga tttttttttt   2803

 tttgttttcc ctaacaattt ggacactaca attgctctca caaaggaggt tcaaagacca   2863

 gtttgtaccg atgaaacgcg caactttgta atcccaacac tttctatttt ctagaatctt   2923

 ctttgttcat tgggtggttt ttcagtcggc tggaattcta tcttctgggg gccttccgtc   2983

 tgagatggaa gctgtcttgg gcttgttgtc tcttccttct gttgctccct gcccctcccc   3043

 ctgcctttcc actctgtctg gtgagctctg ctttttcagt gcaccatcaa gagatgcagc   3103

 cccgtggaca tgaagacaca atctcccacg gacagctttc ccccttccgc cctctcccac   3163

 cctctcctcc ccttgcgctc gcgctcgcgc tcgctttctc actggcgtgc tctctttctc   3223

 tctctctctc cctctgtacc tttctcatag ttgcttcaga tcttaggtct caagggcact   3283

 ttggcgcgta gtaagtgctt tatgtaagaa ggcagggcag gggggctttt tacaggagaa   3343

 aaaaaaatga cttataagag aaagagcctg gagtattttt ggaaaaaaaa ataatatttt   3403

 tatgttaaaa caattttaaa atcttaaaat ggccatcaga catagagagc tttgtgtgat   3463

 tcatgtttta aaaagaaccg aagaagccac aggcagggcc tgagggagcc cctggctttc   3523

 ccctcagcct caggaaaggt ggtcaggaaa actctggctg gacaagggtc agtcttcggg   3583

 gtcagcagcg agattgctct gcagccagtg agggaggtcc ccgccatgcc ggctggaaga   3643

 agaacctcgc atcttttggt gtgtatgcac cttggcagcc agcaggaaag cagcgaagag   3703

 ccgcgcgccc tctggcctca agggagcatt ggcagaacca taaggtactg cagaagccgt   3763

 cgaaaccgac tgctcggctg gattaggcgt gttggctaca tctttcccac aaccgtataa   3823

 cgaccgatgg tcatttctcc aagagcaggc ttggcgagtc cttgcagagc tgacatagag   3883

 gcgcccgcat gtcacttagt ctaacgctga cagaaatgaa tgcagaagga agattttcag   3943

 tcctgaacgt gaattataga ggtagaacgt cgctaataat ttctgccatc tttataattt   4003

 ctttgtctca cagaagacta ggagaaagat cttttttaaa taatcttttt gctgttttta   4063

 aaaaattaaa caaggctttg tgttcctaga agagcttcat ttcagtgaat ctggtgacct   4123

 ccatctgctt gctgtcataa cccgacacgg acttattttt gtcattagca agggggaaaa   4183

 ggccaaagga caagggcctc ttctcccatt ggttttcctg tgggcagaag ggctgaggaa   4243

 gatggcccag cccgtggggg ctgctgggtc accagcagtg ggtagggtgc aatctggtgt   4303

 gtgttccagc agtgagacgg tgttattgtg aaggtggcat tcatctgcgg agccaaaacc   4363

 cagccatcgg ggaagggtca gggcttctgt ggaacttgga acgtgccagg accacctgca   4423

 aaagccaggg tgcgttgatc attctcagat cattgattgg cctccacttg ggtatgtgaa   4483

 ttattcatgt cccagaagac caaaaagtgc tctggttctg agatgagtat tttattcgtg   4543

 ttctgtttcc gaaacactta gcaaagaagg tcacagtgat gtggagtcgc cgcacccatc   4603

 tttgaagata gccagtgtcc ctggatgagg tgatgatttc ccgtcccaag gactctgtga   4663

 agtttagagt acagtttgtt ggggtccaaa agacaccatc tctaccccac ccaaataaaa   4723

 atgcactcat ctctgtagaa catctgctgt caaaggccag cctgtcgtta gggcatggct   4783

 tatgcttgac aaaccagtaa caactgtggg atggcgatgg tgggatgtgt cgcaagcaat   4843

 tcactagaca atcttcacat gaatgtcggt agccagggtc tctcccgagg gatggcttta   4903

 gtcttgatga atgtgaacca tgtcggaatt gttaggtaga aacctgggct gggaggcctc   4963

 ggaccccagg ctccatccct ggcttcccca gcctgcggcc gcaagcaaaa ccaagcgcga   5023

 gatgcagcta gcacccttca tatccatccc cgttctcagc gggacaacac catggacagc   5083

 cgttttcaga gcctccagca tttgcacacc actactcacc ctctctgctg ctggcatgtt   5143

 ggtagagtca tccctgtaat caagaaatgg cctgtggaat gttattgttc aacgttgttt   5203

 acagctctta aaacatggtg aggaatgcct aagtcttagt gaccaaacgt gaccttgaaa   5263

 gcagacatag catgacagac cttcctagag tgtttggtcg ggttcacagt gaccgagagt   5323

 caggtccagc acacacctgg gaaagggatg ctgccccaag ggggaccaaa agggccggac   5383

 gttacagggt gaaaccctct gacccctcgc gacaccgtag gacttgactt ttgtttagtc   5443

 tttctaagaa atagatcatg gagccaagtg aagtgcactt tgtcaaatgt aagggtctgc   5503

 tttgttcttg ttgcttttct gttttttaac cttttgttcc gccatttaaa aaaagaaaaa   5563

 aaaaaagctt atgtttcttg tcaaatgcag aaatgttcct tccgccactc actgaagttt   5623

 tgcattctgg cttgtgcagt ttttattgtc tgtgtcagac gtacagccag acatgttctc   5683

 tattggcatt tttccgattc tgttcagatg acagcgaccg ccttttcatt ccccccgcca   5743

 cctgtactca ccctcacgct ctttgaagaa aaaaaaaaaa                         5783




      <210> 488
      <211> 2389
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(2389)

      <400> 488
 ttcccgggtc gacgatttcg tccaagacgg actctgggag ggctaaggag ccatc atg      58
                                                              Met
                                                                1

 atc cct aag ctg ctt tcc ctc ctc tgt ttc aga ctg tgc gtg ggc caa      106
 Ile Pro Lys Leu Leu Ser Leu Leu Cys Phe Arg Leu Cys Val Gly Gln
               5                  10                  15

 gga gac aca agg gga gat ggg tca ctg ccc aag ccg tcc ctc agt gcc      154
 Gly Asp Thr Arg Gly Asp Gly Ser Leu Pro Lys Pro Ser Leu Ser Ala
          20                  25                  30

 tgg ccc agc tcg gtg gtt cct gcc aac agc aat gtg acg ctg cga tgt      202
 Trp Pro Ser Ser Val Val Pro Ala Asn Ser Asn Val Thr Leu Arg Cys
      35                  40                  45

 tgg act cct gcc aga ggt gtg agc ttt gtt ctc agg aag gga gga att      250
 Trp Thr Pro Ala Arg Gly Val Ser Phe Val Leu Arg Lys Gly Gly Ile
  50                  55                  60                  65

 att ctg gag tcc ccg aag ccc ctt gat tct aca gag ggc gcg gcc gaa      298
 Ile Leu Glu Ser Pro Lys Pro Leu Asp Ser Thr Glu Gly Ala Ala Glu
                  70                  75                  80

 ttt cac ctc aat aat cta aaa gtc aga aat gct gga gag tac acc tgt      346
 Phe His Leu Asn Asn Leu Lys Val Arg Asn Ala Gly Glu Tyr Thr Cys
              85                  90                  95

 gaa tac tac aga aaa gca tcc ccc cac atc ctt tca cag cgc agt gac      394
 Glu Tyr Tyr Arg Lys Ala Ser Pro His Ile Leu Ser Gln Arg Ser Asp
         100                 105                 110

 gtc ctt cta ctg ttg gtg aca gga cat tta tct aaa cct ttc ctc cga      442
 Val Leu Leu Leu Leu Val Thr Gly His Leu Ser Lys Pro Phe Leu Arg
     115                 120                 125

 acc tac caa agg ggt aca gtg acc gca ggt gga agg gtg act ctg cag      490
 Thr Tyr Gln Arg Gly Thr Val Thr Ala Gly Gly Arg Val Thr Leu Gln
 130                 135                 140                 145

 tgc cag aag cga gac caa ttg ttt gtg cct atc atg ttc gct cta ctg      538
 Cys Gln Lys Arg Asp Gln Leu Phe Val Pro Ile Met Phe Ala Leu Leu
                 150                 155                 160

 aag gca ggg acg cca tca ccc atc cag ctg cag agt cca gcg ggg aag      586
 Lys Ala Gly Thr Pro Ser Pro Ile Gln Leu Gln Ser Pro Ala Gly Lys
             165                 170                 175

 gag ata gac ttc tct ctg gtg gac gtg aca gcc ggc gat gct ggg aac      634
 Glu Ile Asp Phe Ser Leu Val Asp Val Thr Ala Gly Asp Ala Gly Asn
         180                 185                 190

 tac agc tgc atg tac tac cag aca aag tct ccc ttc tgg gcc tca gaa      682
 Tyr Ser Cys Met Tyr Tyr Gln Thr Lys Ser Pro Phe Trp Ala Ser Glu
     195                 200                 205

 ccc agt gat cag ctt gag ata ttg gtg aca gct gaa acc tgc ggc tcc      730
 Pro Ser Asp Gln Leu Glu Ile Leu Val Thr Ala Glu Thr Cys Gly Ser
 210                 215                 220                 225

 cag ggt tcc tct gtc cgt acc tgt gct gtc cag cac ggt agc cgc tgg      778
 Gln Gly Ser Ser Val Arg Thr Cys Ala Val Gln His Gly Ser Arg Trp
                 230                 235                 240

 cca cag ccg cta gga gat aag tta ttc cgt tgg tgg ctt ctc ccc ctg      826
 Pro Gln Pro Leu Gly Asp Lys Leu Phe Arg Trp Trp Leu Leu Pro Leu
             245                 250                 255

 agc agg ttc ctc atg aga gtg ctg gac tcc tac ggg gat gac tac cgg      874
 Ser Arg Phe Leu Met Arg Val Leu Asp Ser Tyr Gly Asp Asp Tyr Arg
         260                 265                 270

 gcc agc cag ttc acc att gtg ctg gag gat gag ggc agc cag ggc acg      922
 Ala Ser Gln Phe Thr Ile Val Leu Glu Asp Glu Gly Ser Gln Gly Thr
     275                 280                 285

 gat gcc ccc acc cca ggc aat gcg gag aat gag ctc aga gaa aga gac      970
 Asp Ala Pro Thr Pro Gly Asn Ala Glu Asn Glu Leu Arg Glu Arg Asp
 290                 295                 300                 305

 act gtc ccc gcc cag aag gac tcc tgc acc ccc aga acc cgg cag ccc     1018
 Thr Val Pro Ala Gln Lys Asp Ser Cys Thr Pro Arg Thr Arg Gln Pro
                 310                 315                 320

 agc ccc cgc tac tcc ttg gga aag gcc tgg aaa gaa gct aca gca cag     1066
 Ser Pro Arg Tyr Ser Leu Gly Lys Ala Trp Lys Glu Ala Thr Ala Gln
             325                 330                 335

 ggc aca gcg ggg tct aag gac cgt tcc gcg gag ctc agc cag cag gac     1114
 Gly Thr Ala Gly Ser Lys Asp Arg Ser Ala Glu Leu Ser Gln Gln Asp
         340                 345                 350

 tgt ggg gct gca gga aag gac agt cca gcc cag ggt ccc agc ttc tcc     1162
 Cys Gly Ala Ala Gly Lys Asp Ser Pro Ala Gln Gly Pro Ser Phe Ser
     355                 360                 365

 gcc act cag ttg gct gct cca ggc agg cct ggc gct gac ctg agc gag     1210
 Ala Thr Gln Leu Ala Ala Pro Gly Arg Pro Gly Ala Asp Leu Ser Glu
 370                 375                 380                 385

 gct ctg gtg cac gct ggg cct ctc tgc cca ccc cct gct ctg gac ttt     1258
 Ala Leu Val His Ala Gly Pro Leu Cys Pro Pro Pro Ala Leu Asp Phe
                 390                 395                 400

 tcc gat gga gca cgc cca tcg ctg tct tct gtg ctg aac gag ctg ccc     1306
 Ser Asp Gly Ala Arg Pro Ser Leu Ser Ser Val Leu Asn Glu Leu Pro
             405                 410                 415

 agt gct gcc acc ctt cgg tac cga gac cct ggg gtg ctg cct tgg ggg     1354
 Ser Ala Ala Thr Leu Arg Tyr Arg Asp Pro Gly Val Leu Pro Trp Gly
         420                 425                 430

 gcg ctg gag gag gag gag gag gat gga gga agg agc aga aag gcc ttc     1402
 Ala Leu Glu Glu Glu Glu Glu Asp Gly Gly Arg Ser Arg Lys Ala Phe
     435                 440                 445

 aca gaa gtc acc cag aca gag ctg cag gac cct cac cct tcc cgg gaa     1450
 Thr Glu Val Thr Gln Thr Glu Leu Gln Asp Pro His Pro Ser Arg Glu
 450                 455                 460                 465

 ctg ccc tgg ccc atg cag gcc aga cgg gca cac agg caa aga aat gcc     1498
 Leu Pro Trp Pro Met Gln Ala Arg Arg Ala His Arg Gln Arg Asn Ala
                 470                 475                 480

 agc agg gac cag gtg gtc tat ggc tct gga act aag acg gac cga tgg     1546
 Ser Arg Asp Gln Val Val Tyr Gly Ser Gly Thr Lys Thr Asp Arg Trp
             485                 490                 495

 gcg cgg cta ctt cgg agg tcc aag gag aaa aca aag gaa ggc ttg cga     1594
 Ala Arg Leu Leu Arg Arg Ser Lys Glu Lys Thr Lys Glu Gly Leu Arg
         500                 505                 510

 agc ctg cag ccc tgg gcg tgg aca ctg aag agg atc ggg ggt gcg gtg     1642
 Ser Leu Gln Pro Trp Ala Trp Thr Leu Lys Arg Ile Gly Gly Ala Val
     515                 520                 525

 ccg ata cag aac gtg acc ccc cac caa gct tca cca cag agg aat gag     1690
 Pro Ile Gln Asn Val Thr Pro His Gln Ala Ser Pro Gln Arg Asn Glu
 530                 535                 540                 545

 gtg gag gcc tca cga tgg acc gaa gct gcg ttg gca gcg aga tta gct     1738
 Val Glu Ala Ser Arg Trp Thr Glu Ala Ala Leu Ala Ala Arg Leu Ala
                 550                 555                 560

 ggg att ggc agc tgg agc agc cct tcc ccg ggg cag tgc cag cct gcg     1786
 Gly Ile Gly Ser Trp Ser Ser Pro Ser Pro Gly Gln Cys Gln Pro Ala
             565                 570                 575

 ccc ctg ctg cgc cgc gcc tgg ccg gcc ccg ctc ttc ggc ctg ctg ttc     1834
 Pro Leu Leu Arg Arg Ala Trp Pro Ala Pro Leu Phe Gly Leu Leu Phe
         580                 585                 590

 ctg ctc tcc tct cac ctc ttc ccg ctg gag gcc gtg cgc gag gac gcc     1882
 Leu Leu Ser Ser His Leu Phe Pro Leu Glu Ala Val Arg Glu Asp Ala
     595                 600                 605

 ttc tac gcc cgc ccg ctg ccc gcc cgc ctc ttc tac atg atc ccc gtc     1930
 Phe Tyr Ala Arg Pro Leu Pro Ala Arg Leu Phe Tyr Met Ile Pro Val
 610                 615                 620                 625

 ttc ttc gcc ttc cgc atg cgc ttc tac gtg gcc tgg att gcc gcc gag     1978
 Phe Phe Ala Phe Arg Met Arg Phe Tyr Val Ala Trp Ile Ala Ala Glu
                 630                 635                 640

 tgc gct gca ttg ccg ccg gct ttg ggg cct acc ccg tgg ccg cca aag     2026
 Cys Ala Ala Leu Pro Pro Ala Leu Gly Pro Thr Pro Trp Pro Pro Lys
             645                 650                 655

 ccc ggg ccg gag gcg gcc cca ccc tcc aat gcc cac ccc cca gca gca     2074
 Pro Gly Pro Glu Ala Ala Pro Pro Ser Asn Ala His Pro Pro Ala Ala
         660                 665                 670

 agt ctg aca gcc aga ggg cca ttg cct ggc cag gat ccc ttc ctt agc     2122
 Ser Leu Thr Ala Arg Gly Pro Leu Pro Gly Gln Asp Pro Phe Leu Ser
     675                 680                 685

 atc cgg ggc tgg gac act agc agg cgt cgg gag ggg gcc tgg ctg agc     2170
 Ile Arg Gly Trp Asp Thr Ser Arg Arg Arg Glu Gly Ala Trp Leu Ser
 690                 695                 700                 705

 tgc atg tct gtc ccc cac cct cat cct cca ccc ccc agt ccg gag aag     2218
 Cys Met Ser Val Pro His Pro His Pro Pro Pro Pro Ser Pro Glu Lys
                 710                 715                 720

 gcg gct tcc ttg gag tat gac tat gag acc atc cgc aac atc gac tgc     2266
 Ala Ala Ser Leu Glu Tyr Asp Tyr Glu Thr Ile Arg Asn Ile Asp Cys
             725                 730                 735

 tac agc aca gat ttc tgc gtg cgg gtg cgc gat ggc atg cgg tac tgg     2314
 Tyr Ser Thr Asp Phe Cys Val Arg Val Arg Asp Gly Met Arg Tyr Trp
         740                 745                 750

 aac atg acg gtg cag tgg tgg ctg gcg cag tat atc tac aag agc gca     2362
 Asn Met Thr Val Gln Trp Trp Leu Ala Gln Tyr Ile Tyr Lys Ser Ala
     755                 760                 765

 cct gcc cgt tcc tat gtc ctg cgg tga                                 2389
 Pro Ala Arg Ser Tyr Val Leu Arg 
 770                 775





      <210> 489
      <211> 2389
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(2389)

      <400> 489
 ttcccgggtc gacgatttcg tccaagacgg actctgggag ggctaaggag ccatc atg      58
                                                              Met
                                                                1

 atc cct aag ctg ctt tcc ctc ctc tgt ttc aga ctg tgc gtg ggc caa      106
 Ile Pro Lys Leu Leu Ser Leu Leu Cys Phe Arg Leu Cys Val Gly Gln
               5                  10                  15

 gga gac aca agg gga gat ggg tca ctg ccc aag ccg tcc ctc agt gcc      154
 Gly Asp Thr Arg Gly Asp Gly Ser Leu Pro Lys Pro Ser Leu Ser Ala
          20                  25                  30

 tgg ccc agc tcg gtg gtt cct gcc aac agc aat gtg acg ctg cga tgt      202
 Trp Pro Ser Ser Val Val Pro Ala Asn Ser Asn Val Thr Leu Arg Cys
      35                  40                  45

 tgg act cct gcc aga ggt gtg agc ttt gtt ctc agg aag gga gga att      250
 Trp Thr Pro Ala Arg Gly Val Ser Phe Val Leu Arg Lys Gly Gly Ile
  50                  55                  60                  65

 att ctg gag tcc ccg aag ccc ctt gat tct aca gag ggc gcg gcc gaa      298
 Ile Leu Glu Ser Pro Lys Pro Leu Asp Ser Thr Glu Gly Ala Ala Glu
                  70                  75                  80

 ttt cac ctc aat aat cta aaa gtc aga aat gct gga gag tac acc tgt      346
 Phe His Leu Asn Asn Leu Lys Val Arg Asn Ala Gly Glu Tyr Thr Cys
              85                  90                  95

 gaa tac tac aga aaa gca tcc ccc cac atc ctt tca cag cgc agt gac      394
 Glu Tyr Tyr Arg Lys Ala Ser Pro His Ile Leu Ser Gln Arg Ser Asp
         100                 105                 110

 gtc ctt cta ctg ttg gtg aca gga cat tta tct aaa cct ttc ctc cga      442
 Val Leu Leu Leu Leu Val Thr Gly His Leu Ser Lys Pro Phe Leu Arg
     115                 120                 125

 acc tac caa agg ggt aca gtg acc gca ggt gga agg gtg act ctg cag      490
 Thr Tyr Gln Arg Gly Thr Val Thr Ala Gly Gly Arg Val Thr Leu Gln
 130                 135                 140                 145

 tgc cag aag cga gac caa ttg ttt gtg cct atc atg ttc gct cta ctg      538
 Cys Gln Lys Arg Asp Gln Leu Phe Val Pro Ile Met Phe Ala Leu Leu
                 150                 155                 160

 aag gca ggg acg cca tca ccc atc cag ctg cag agt cca gcg ggg aag      586
 Lys Ala Gly Thr Pro Ser Pro Ile Gln Leu Gln Ser Pro Ala Gly Lys
             165                 170                 175

 gag ata gac ttc tct ctg gtg gac gtg aca gcc ggc gat gct ggg aac      634
 Glu Ile Asp Phe Ser Leu Val Asp Val Thr Ala Gly Asp Ala Gly Asn
         180                 185                 190

 tac agc tgc atg tac tac cag aca aag tct ccc ttc tgg gcc tca gaa      682
 Tyr Ser Cys Met Tyr Tyr Gln Thr Lys Ser Pro Phe Trp Ala Ser Glu
     195                 200                 205

 ccc agt gat cag ctt gag ata ttg gtg aca gct gaa acc tgc ggc tcc      730
 Pro Ser Asp Gln Leu Glu Ile Leu Val Thr Ala Glu Thr Cys Gly Ser
 210                 215                 220                 225

 cag ggt tcc tct gtc cgt acc tgt gct gtc cag cac ggt agc cgc tgg      778
 Gln Gly Ser Ser Val Arg Thr Cys Ala Val Gln His Gly Ser Arg Trp
                 230                 235                 240

 cca cag ccg cta gga gat aag tta ttc cgt tgg tgg ctt ctc ccc ctg      826
 Pro Gln Pro Leu Gly Asp Lys Leu Phe Arg Trp Trp Leu Leu Pro Leu
             245                 250                 255

 agc agg ttc ctc atg aga gtg ctg gac tcc tac ggg gat gac tac cgg      874
 Ser Arg Phe Leu Met Arg Val Leu Asp Ser Tyr Gly Asp Asp Tyr Arg
         260                 265                 270

 gcc agc cag ttc acc att gtg ctg gag gat gag ggc agc cag ggc acg      922
 Ala Ser Gln Phe Thr Ile Val Leu Glu Asp Glu Gly Ser Gln Gly Thr
     275                 280                 285

 gat gcc ccc acc cca ggc aat gcg gag aat gag ctc aga gaa aga gac      970
 Asp Ala Pro Thr Pro Gly Asn Ala Glu Asn Glu Leu Arg Glu Arg Asp
 290                 295                 300                 305

 act gtc ccc gcc cag aag gac tcc tgc acc ccc aga acc cgg cag ccc     1018
 Thr Val Pro Ala Gln Lys Asp Ser Cys Thr Pro Arg Thr Arg Gln Pro
                 310                 315                 320

 agc ccc cgc tac tcc ttg gga aag gcc tgg aaa gaa gct aca gca cag     1066
 Ser Pro Arg Tyr Ser Leu Gly Lys Ala Trp Lys Glu Ala Thr Ala Gln
             325                 330                 335

 ggc aca gcg ggg tct aag gac cgt tcc gcg gag ctc agc cag cag gac     1114
 Gly Thr Ala Gly Ser Lys Asp Arg Ser Ala Glu Leu Ser Gln Gln Asp
         340                 345                 350

 tgt ggg gct gca gga aag gac agt cca gcc cag ggt ccc agc ttc tcc     1162
 Cys Gly Ala Ala Gly Lys Asp Ser Pro Ala Gln Gly Pro Ser Phe Ser
     355                 360                 365

 gcc act cag ttg gct gct cca ggc agg cct ggc gct gac ctg agc gag     1210
 Ala Thr Gln Leu Ala Ala Pro Gly Arg Pro Gly Ala Asp Leu Ser Glu
 370                 375                 380                 385

 gct ctg gtg cac gct ggg cct ctc tgc cca ccc cct gct ctg gac ttt     1258
 Ala Leu Val His Ala Gly Pro Leu Cys Pro Pro Pro Ala Leu Asp Phe
                 390                 395                 400

 tcc gat gga gca cgc cca tcg ctg tct tct gtg ctg aac gag ctg ccc     1306
 Ser Asp Gly Ala Arg Pro Ser Leu Ser Ser Val Leu Asn Glu Leu Pro
             405                 410                 415

 agt gct gcc acc ctt cgg tac cga gac cct ggg gtg ctg cct tgg ggg     1354
 Ser Ala Ala Thr Leu Arg Tyr Arg Asp Pro Gly Val Leu Pro Trp Gly
         420                 425                 430

 gcg ctg gag gag gag gag gag gat gga gga agg agc aga aag gcc ttc     1402
 Ala Leu Glu Glu Glu Glu Glu Asp Gly Gly Arg Ser Arg Lys Ala Phe
     435                 440                 445

 aca gaa gtc acc cag aca gag ctg cag gac cct cac cct tcc cgg gaa     1450
 Thr Glu Val Thr Gln Thr Glu Leu Gln Asp Pro His Pro Ser Arg Glu
 450                 455                 460                 465

 ctg ccc tgg ccc atg cag gcc aga cgg gca cac agg caa aga aat gcc     1498
 Leu Pro Trp Pro Met Gln Ala Arg Arg Ala His Arg Gln Arg Asn Ala
                 470                 475                 480

 agc agg gac cag gtg gtc tat ggc tct gga act aag acg gac cga tgg     1546
 Ser Arg Asp Gln Val Val Tyr Gly Ser Gly Thr Lys Thr Asp Arg Trp
             485                 490                 495

 gcg cgg cta ctt cgg agg tcc aag gag aaa aca aag gaa ggc ttg cga     1594
 Ala Arg Leu Leu Arg Arg Ser Lys Glu Lys Thr Lys Glu Gly Leu Arg
         500                 505                 510

 agc ctg cag ccc tgg gcg tgg aca ctg aag agg atc ggg ggt gcg gtg     1642
 Ser Leu Gln Pro Trp Ala Trp Thr Leu Lys Arg Ile Gly Gly Ala Val
     515                 520                 525

 ccg ata cag aac gtg acc ccc cac caa gct tca cca cag agg aat gag     1690
 Pro Ile Gln Asn Val Thr Pro His Gln Ala Ser Pro Gln Arg Asn Glu
 530                 535                 540                 545

 gtg gag gcc tca cga tgg acc gaa gct gcg ttg gca gcg aga tta gct     1738
 Val Glu Ala Ser Arg Trp Thr Glu Ala Ala Leu Ala Ala Arg Leu Ala
                 550                 555                 560

 ggg att ggc agc tgg agc agc cct tcc ccg ggg cag tgc cag cct gcg     1786
 Gly Ile Gly Ser Trp Ser Ser Pro Ser Pro Gly Gln Cys Gln Pro Ala
             565                 570                 575

 ccc ctg ctg cgc cgc gcc tgg ccg gcc ccg ctc ttc ggc ctg ctg ttc     1834
 Pro Leu Leu Arg Arg Ala Trp Pro Ala Pro Leu Phe Gly Leu Leu Phe
         580                 585                 590

 ctg ctc tcc tct cac ctc ttc ccg ctg gag gcc gtg cgc gag gac gcc     1882
 Leu Leu Ser Ser His Leu Phe Pro Leu Glu Ala Val Arg Glu Asp Ala
     595                 600                 605

 ttc tac gcc cgc ccg ctg ccc gcc cgc ctc ttc tac atg atc ccc gtc     1930
 Phe Tyr Ala Arg Pro Leu Pro Ala Arg Leu Phe Tyr Met Ile Pro Val
 610                 615                 620                 625

 ttc ttc gcc ttc cgc atg cgc ttc tac gtg gcc tgg att gcc gcc gag     1978
 Phe Phe Ala Phe Arg Met Arg Phe Tyr Val Ala Trp Ile Ala Ala Glu
                 630                 635                 640

 tgc gct gca ttg ccg ccg gct ttg ggg cct acc ccg tgg ccg cca aag     2026
 Cys Ala Ala Leu Pro Pro Ala Leu Gly Pro Thr Pro Trp Pro Pro Lys
             645                 650                 655

 ccc ggg ccg gag gcg gcc cca ccc tcc aat gcc cac ccc cca gca gca     2074
 Pro Gly Pro Glu Ala Ala Pro Pro Ser Asn Ala His Pro Pro Ala Ala
         660                 665                 670

 agt ctg aca gcc aga ggg cca ttg cct ggc cag gat ccc ttc ctt agc     2122
 Ser Leu Thr Ala Arg Gly Pro Leu Pro Gly Gln Asp Pro Phe Leu Ser
     675                 680                 685

 atc cgg ggc tgg gac act agc agg cgt cgg gag ggg gcc tgg ctg agc     2170
 Ile Arg Gly Trp Asp Thr Ser Arg Arg Arg Glu Gly Ala Trp Leu Ser
 690                 695                 700                 705

 tgc atg tct gtc ccc cac cct cat cct cca ccc ccc agt ccg gag aag     2218
 Cys Met Ser Val Pro His Pro His Pro Pro Pro Pro Ser Pro Glu Lys
                 710                 715                 720

 gcg gct tcc ttg gag tat gac tat gag acc atc cgc aac atc gac tgc     2266
 Ala Ala Ser Leu Glu Tyr Asp Tyr Glu Thr Ile Arg Asn Ile Asp Cys
             725                 730                 735

 tac agc aca gat ttc tgc gtg cgg gtg cgc gat ggc atg cgg tac tgg     2314
 Tyr Ser Thr Asp Phe Cys Val Arg Val Arg Asp Gly Met Arg Tyr Trp
         740                 745                 750

 aac atg acg gtg cag tgg tgg ctg gcg cag tat atc tac aag agc gca     2362
 Asn Met Thr Val Gln Trp Trp Leu Ala Gln Tyr Ile Tyr Lys Ser Ala
     755                 760                 765

 cct gcc cgt tcc tat gtc ctg cgg tga                                 2389
 Pro Ala Arg Ser Tyr Val Leu Arg 
 770                 775





      <210> 490
      <211> 2544
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (482)..(1690)

      <400> 490
 gttctcgact attgccgaag tgagccgaag tttgtggccc cgcttccgga gaactcaagc     60

 tcccgattgt gcccgaagga acccgaaggg agaccccgcc tcattcctca cgccgagctc    120

 cagaccccgc ctcctttcca gagcccgtct gttccccttc gggtccaaag cttttggctc    180

 ctccttgttc cgagcccgaa ggcccgcccc ttcacgtact cggagctcgg atcccagtgt    240

 ggacctggac tcgaatcccg ttgccgactc gcgctctcgg cttctgctcc ggggcttctt    300

 ccctgcccgc ccggggccct gaccgtggct tcttccccgg cctgatctgc gcagcccggc    360

 gggcgcccag aaggagcagg cggcgcgggg gcgcgctggg cgggggaggc gtggccggag    420

 ctgcggcggc aagcgggctg ggactgctcg gccgcctcct gcccggcgag cagctcagac    480

 c    atg tcg cct gaa gaa tgg acg tat cta gtg gtt ctt ctt atc tcc     526
      Met Ser Pro Glu Glu Trp Thr Tyr Leu Val Val Leu Leu Ile Ser
        1               5                  10                  15

 atc ccc atc ggc ttc ctc ttt aag aaa gcc ggt cct ggg ctg aag aga      574
 Ile Pro Ile Gly Phe Leu Phe Lys Lys Ala Gly Pro Gly Leu Lys Arg
                  20                  25                  30

 tgg gga gca gcc gct gtg ggc ctg ggg ctc acc ctg ttc acc tgt ggc      622
 Trp Gly Ala Ala Ala Val Gly Leu Gly Leu Thr Leu Phe Thr Cys Gly
              35                  40                  45

 ccc cac act ttg cat tct ctg gtc acc atc ctc ggg acc tgg gcc ctc      670
 Pro His Thr Leu His Ser Leu Val Thr Ile Leu Gly Thr Trp Ala Leu
          50                  55                  60

 att cag gcc cag ccc tgc ccc tgc cac gcc ctg gct ctg gcc tgg act      718
 Ile Gln Ala Gln Pro Cys Pro Cys His Ala Leu Ala Leu Ala Trp Thr
      65                  70                  75

 ttc tcc tat ctc ctg ttc ttc cga gcc ctc agc ctc ctg ggc ctg ccc      766
 Phe Ser Tyr Leu Leu Phe Phe Arg Ala Leu Ser Leu Leu Gly Leu Pro
  80                  85                  90                  95

 act ccc acg ccc ttc acc aat gcc gtc cag ctg ctg ctg acg ctg aag      814
 Thr Pro Thr Pro Phe Thr Asn Ala Val Gln Leu Leu Leu Thr Leu Lys
                 100                 105                 110

 ctg gtg agc ctg gcc agt gaa gtc cag gac ctg cat ctg gcc cag agg      862
 Leu Val Ser Leu Ala Ser Glu Val Gln Asp Leu His Leu Ala Gln Arg
             115                 120                 125

 aag gaa atg gcc tca ggc ttc agc aag ggg ccc acc ctg ggg ctg ctg      910
 Lys Glu Met Ala Ser Gly Phe Ser Lys Gly Pro Thr Leu Gly Leu Leu
         130                 135                 140

 ccc gac gtg ccc tcc ctg atg gag aca ctc agc tac agc tac tgc tac      958
 Pro Asp Val Pro Ser Leu Met Glu Thr Leu Ser Tyr Ser Tyr Cys Tyr
     145                 150                 155

 gtg gga atc atg aca ggc ccg ttc ttc cgc tac cgc acc tac ctg gac     1006
 Val Gly Ile Met Thr Gly Pro Phe Phe Arg Tyr Arg Thr Tyr Leu Asp
 160                 165                 170                 175

 tgg ctg gag cag ccc ttc ccc ggg gca gtg ccc agc ctg cgg ccc ctg     1054
 Trp Leu Glu Gln Pro Phe Pro Gly Ala Val Pro Ser Leu Arg Pro Leu
                 180                 185                 190

 ctg cgc cgc gcc tgg ccg gcc ccg ctc ttc ggc ctg ctg ttc ctg ctc     1102
 Leu Arg Arg Ala Trp Pro Ala Pro Leu Phe Gly Leu Leu Phe Leu Leu
             195                 200                 205

 tcc tct cac ctc ttc ccg ctg gag gcc gtg cgc gag gac gcc ttc tac     1150
 Ser Ser His Leu Phe Pro Leu Glu Ala Val Arg Glu Asp Ala Phe Tyr
         210                 215                 220

 gcc cgc ccg ctg ccc gcc cgc ctc ttc tac atg atc ccc gtc ttc ttc     1198
 Ala Arg Pro Leu Pro Ala Arg Leu Phe Tyr Met Ile Pro Val Phe Phe
     225                 230                 235

 gcc ttc cgc atg cgc ttc tac gtg gcc tgg att gcc gcc gag tgc ggc     1246
 Ala Phe Arg Met Arg Phe Tyr Val Ala Trp Ile Ala Ala Glu Cys Gly
 240                 245                 250                 255

 tgc att gcc gcc ggc ttt ggg gcc tac ccc gtg gcc gcc aaa gcc cgg     1294
 Cys Ile Ala Ala Gly Phe Gly Ala Tyr Pro Val Ala Ala Lys Ala Arg
                 260                 265                 270

 gcc gga ggc ggc ccc acc ctc caa tgc cca ccc ccc agc agt ccg gag     1342
 Ala Gly Gly Gly Pro Thr Leu Gln Cys Pro Pro Pro Ser Ser Pro Glu
             275                 280                 285

 aag gcg gct tcc ttg gag tat gac tat gag acc atc cgc aac atc gac     1390
 Lys Ala Ala Ser Leu Glu Tyr Asp Tyr Glu Thr Ile Arg Asn Ile Asp
         290                 295                 300

 tgc tac agc aca gat ttc tgc gtg cgg gtg cgc gat ggc atg cgg tac     1438
 Cys Tyr Ser Thr Asp Phe Cys Val Arg Val Arg Asp Gly Met Arg Tyr
     305                 310                 315

 tgg aac atg acg gtg cag tgg tgg ctg gcg cag tat atc tac aag agc     1486
 Trp Asn Met Thr Val Gln Trp Trp Leu Ala Gln Tyr Ile Tyr Lys Ser
 320                 325                 330                 335

 gca cct gcc cgt tcc tat gtc ctg cgg agc gcc tgg acc atg ctg ctg     1534
 Ala Pro Ala Arg Ser Tyr Val Leu Arg Ser Ala Trp Thr Met Leu Leu
                 340                 345                 350

 agg cgc cta ctg gca cgg cct cca ccc ggg cta cta cct gag ctt cct     1582
 Arg Arg Leu Leu Ala Arg Pro Pro Pro Gly Leu Leu Pro Glu Leu Pro
             355                 360                 365

 gac cat ccc gct gtg cct ggc tgc cga ggg ccg gct gga gtc agc cct     1630
 Asp His Pro Ala Val Pro Gly Cys Arg Gly Pro Ala Gly Val Ser Pro
         370                 375                 380

 gcg ggg gcg gct gag ccc agg ggg cca gaa ggt cct ggg act ggg tgc     1678
 Ala Gly Ala Ala Glu Pro Arg Gly Pro Glu Gly Pro Gly Thr Gly Cys
     385                 390                 395

 act ggt tcc tga aga tgcgcgccta tgactacatg tgcatgggct tcgtgctgct     1733
 Thr Gly Ser 
 400

 ctccttggcc gacacccttc ggtactgggc ctccatctac ttctgtatcc acttcctggc   1793

 cctggcagcc ctggggctgg ggctggcttt aggtgggggc agccccagcc ggcggaaggc   1853

 agcatcccag cccaccagcc ttgccccgga gaagctccgg gaggagtaag ctgtcacgac   1913

 gctccctctg ccagctggtc ccgggaattc tgtgaaccag gctgctgtct cctccccaga   1973

 aagagtcctt accttggaga gggtcctgga gagaatttcc tcttccccag ctaaataccc   2033

 tgcctgcaac tgaagcagac ccgggggtgt cctccctgcc ctctgcccag aggccacctc   2093

 cactcctaca aaatcaaagt attgtccaga caagagtcac tggcccctgc tccagcttct   2153

 gggtatccag agagcactgc acttccccaa aacggaaggg gcccctgggc agtgggtttt   2213

 gggcaaattc cctttctttg catccacaat gtggggtcgg agcttggggg caggtcctgg   2273

 gagtgggaag cctcttcctt gtgtctttcg ctccactttt agctcatcgc accaatattg   2333

 cagacttgga aggaagcata agcttcccat ttcacaaagg ggaaactgag gtgcgggtgc   2393

 gcgggcctgg ggacggccgt cccatggctt ccatctgagc cacctcggga ccccagcgct   2453

 cctggcgccc tcttctcatc gcttggccta tgacaggtca ccgtgtgtaa atctttccca   2513

 ataaagtgtt gcacaaagga aaaaaaaaaa a                                  2544




      <210> 491
      <211> 1067
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (121)..(822)

      <400> 491
 gggagactaa aaaggccagg gaagttggcc tgccggaagt tcccagggag aaggcagcgc     60

 gttgtacccg agaaaaaaga aatcctcttt ttagaacatc tcttggtggt accatcagaa    120
                                                                 
 atg tct tcc tta agt gga aaa gtc caa acc gtt ttg ggc ctt gta gag      168
 Met Ser Ser Leu Ser Gly Lys Val Gln Thr Val Leu Gly Leu Val Glu
   1               5                  10                  15

 cca agc aaa ctg ggc cgt acc ctg acc cat gaa cac ctg gcc atg acc      216
 Pro Ser Lys Leu Gly Arg Thr Leu Thr His Glu His Leu Ala Met Thr
              20                  25                  30

 ttt gac tgc tgt tac tgt cca cct ccc ccg tgc cag gaa gct att tcc      264
 Phe Asp Cys Cys Tyr Cys Pro Pro Pro Pro Cys Gln Glu Ala Ile Ser
          35                  40                  45

 aaa gaa cct atc gtg atg aaa aat tta tat tgg att cag aaa aac gcc      312
 Lys Glu Pro Ile Val Met Lys Asn Leu Tyr Trp Ile Gln Lys Asn Ala
      50                  55                  60

 tat tcc cat aaa gaa aac ctt caa tta aat cag gag aca gaa gcc ata      360
 Tyr Ser His Lys Glu Asn Leu Gln Leu Asn Gln Glu Thr Glu Ala Ile
  65                  70                  75                  80

 aag gaa gaa ctg ttg tat ttt aaa gct aat ggt gga ggg gct ttg gtg      408
 Lys Glu Glu Leu Leu Tyr Phe Lys Ala Asn Gly Gly Gly Ala Leu Val
                  85                  90                  95

 gaa aac aca acc act ggg att agc cga gac aca cag acg ttg aag agg      456
 Glu Asn Thr Thr Thr Gly Ile Ser Arg Asp Thr Gln Thr Leu Lys Arg
             100                 105                 110

 ctt gca gaa gag act ggc gtc cat atc ata tct gga gcc ggg ttt tat      504
 Leu Ala Glu Glu Thr Gly Val His Ile Ile Ser Gly Ala Gly Phe Tyr
         115                 120                 125

 gtg gat gca act cac tcc tca gag acc agg gcc atg tca gtg gag cag      552
 Val Asp Ala Thr His Ser Ser Glu Thr Arg Ala Met Ser Val Glu Gln
     130                 135                 140

 ctt acc gat gtc ctt atg aat gaa att ctc cat gga gct gat gga acc      600
 Leu Thr Asp Val Leu Met Asn Glu Ile Leu His Gly Ala Asp Gly Thr
 145                 150                 155                 160

 agt atc aag tgt ggc att att gga gaa att ggt tgc tcc tgg cct ttg      648
 Ser Ile Lys Cys Gly Ile Ile Gly Glu Ile Gly Cys Ser Trp Pro Leu
                 165                 170                 175

 act gag agt gaa aga aag gtt ctc cag gcc aca gct cat gcc cag gct      696
 Thr Glu Ser Glu Arg Lys Val Leu Gln Ala Thr Ala His Ala Gln Ala
             180                 185                 190

 cag ctt ggt tgt cct gtt att atc cat cct gga cgg agc tcc agg gca      744
 Gln Leu Gly Cys Pro Val Ile Ile His Pro Gly Arg Ser Ser Arg Ala
         195                 200                 205

 cca ttt cag att atc cga ata ttg caa gaa gca ggc gca gac atc tcc      792
 Pro Phe Gln Ile Ile Arg Ile Leu Gln Glu Ala Gly Ala Asp Ile Ser
     210                 215                 220

 aaa aca gtc atg tca cac ctg gat agg taa g taggctgtct tacaaatgga      843
 Lys Thr Val Met Ser His Leu Asp Arg 
 225                 230

 tgcaaactgc catataatta atgcatgatc aaattaagaa tctacagtaa tcagtcaatg    903

 caatactaat cacgcagaga aaaccactaa ctatatggaa ggtagtattt ataaagtttc    963

 acaactgaca tgaataaaag tcaatgctgc catttttgtg tccctcctct gtgtcagata   1023

 gtgtcctagg tatttcacat aagatatttt gcataagtgt attc                    1067




      <210> 492
      <211> 1432
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (724)..(909)

      <400> 492
 cgtcagtggc catactccgc acagtgccat catccagaca gtggggggca attccgaagc     60

 ctccggggtt tgatcgtgga gtatagaagc tctgaacgcc acatctctta cagaaggtat    120

 gctgggcttt gtgagtattg aacgtgtaag tcgttatgtg ctcagctccc taggtgaaaa    180

 cagacaaacg gtattctttt ttacaaagag atttatttat ttaatttatt tatttattta    240

 tttattgaga cagagtctcc cactgtctct caggctggag tgcagtggcg caatcttggc    300

 tcactgcaac ctccacctgc atgggttcaa gagattttcc tgcctcagcc tcccaagtag    360

 ctgggaccac aggcatgcac cacaacgccc agctaattct tgcattttca gcagagacag    420

 ggtttcacca tgttggccag gctggtcctc aactcctgac ctcaggtgat ccatccatct    480

 tggcctccca aagtgctggg accacaggcg tgagccactg tgccgggccc accttttaaa    540

 tgtcaacctg aaaccaaagc ccgtgagagg ccctgctatg ctccaggccc ctcccatgct    600

 acagacggca tgctaacggt tgggtggggg gtcctgtaaa tctcaccaat gggttctgca    660

 ctccttgacc ctgctcttaa gcactgacct tcaggagctt gaagcgagaa gctggaacaa    720

 tga  agt gtc tat tct gct tct tct tgc aaa tgc tgc aac tac aga aag     768
      Ser Val Tyr Ser Ala Ser Ser Cys Lys Cys Cys Asn Tyr Arg Lys
        1               5                  10                  15

 aca gag caa att cca gat tgt gag cag cca cct gca tcc tct atg cct      816
 Thr Glu Gln Ile Pro Asp Cys Glu Gln Pro Pro Ala Ser Ser Met Pro
                  20                  25                  30

 gag cgg ccc agc cat gag agc cag ccg acc cca cag atg atg ccc ctt      864
 Glu Arg Pro Ser His Glu Ser Gln Pro Thr Pro Gln Met Met Pro Leu
              35                  40                  45

 tca gca cca tcc agg gcc gag gag ctg ggg caa agg cct gga tag cag      912
 Ser Ala Pro Ser Arg Ala Glu Glu Leu Gly Gln Arg Pro Gly 
          50                  55                  60

 tgcctctggt ttgcaggtac agcagagccc aggggggtcc caagtcagca gtcgaggttc    972

 tgcaatgctc agaacacagg accaacagac aggtctgtac tgcccacccc tcagttcttt   1032

 acagtgaaga gaagcgctgg acttcagaga cacttaggaa acaaatttca gacactgcta   1092

 caacctgatg tctctgagac atccacacca aaaatggaca aggaagttta ggtttccctc   1152

 tttcttcatc accacgtcac aagaagtcca gctccaagta aaacacgtcc ccagaattac   1212

 catctctgga attaaactga agtcccctct tttcaggcca cctttgaaaa agttctaatt   1272

 tagcacagaa tcctctcaca agttattcca cagtgcttct tttccaatct ggactctatt   1332

 gttagtagcc tggtcagttc tccatttgag taattccatc gtatgtgctt attattcata   1392

 tataattccg gtacttgcag tcaaatatat gcaagtctgc                         1432




      <210> 493
      <211> 3476
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (342)..(860)

      <400> 493
 aaggatcctt aattaaatta atcccccccc cccgtcctgc cgcgccggca gccacaggct     60

 ggcatagcgg ctgccgaccc gccctcgttc ctccaccccc tgcacgggac tgctgggccc    120

 gccccgcccc gcctgcaggt gaagcggccg cagccgccga gtaggtgcgt ggggatgatc    180

 tcactcgcgc gctccgcgcc aggaggagga ggagcgggag cggatccaac ttccgggtag    240

 tggagccgca agccaccggc atcttgcttt ttcttccccc tcctcctgtg tgccccgcgc    300

 cgctccctct ttccctttta ttcccggccc cacccgccaa a    atg aac agc tcg     353
                                                  Met Asn Ser Ser
                                                    1

 gac gaa gag aag cag ctg cag ctc att acc agt ctg aag gag caa gca      401
 Asp Glu Glu Lys Gln Leu Gln Leu Ile Thr Ser Leu Lys Glu Gln Ala
   5                  10                  15                  20

 ata ggc gaa tat gaa gac ctt aga gca gag aac cag aaa aca aag gag      449
 Ile Gly Glu Tyr Glu Asp Leu Arg Ala Glu Asn Gln Lys Thr Lys Glu
                  25                  30                  35

 aag tgt gac aaa att agg caa gaa cca gat gaa gcc gtt aaa aaa ctg      497
 Lys Cys Asp Lys Ile Arg Gln Glu Pro Asp Glu Ala Val Lys Lys Leu
              40                  45                  50

 gaa gaa ttt cag aaa att tct cac atg gtc ata gag gaa gtt aat ttc      545
 Glu Glu Phe Gln Lys Ile Ser His Met Val Ile Glu Glu Val Asn Phe
          55                  60                  65

 atg cag aac cat ctt gaa ata gag aag act tgt cga gaa agt gct gaa      593
 Met Gln Asn His Leu Glu Ile Glu Lys Thr Cys Arg Glu Ser Ala Glu
      70                  75                  80

 gct ttg gca aca aag cta aat aaa gaa aat aaa acg ttg aaa aga atc      641
 Ala Leu Ala Thr Lys Leu Asn Lys Glu Asn Lys Thr Leu Lys Arg Ile
  85                  90                  95                 100

 agc atg ttg tac atg gcc aag ctg gga cca gat gta ata act gaa gag      689
 Ser Met Leu Tyr Met Ala Lys Leu Gly Pro Asp Val Ile Thr Glu Glu
                 105                 110                 115

 ata aac att gat gat gaa gat tcg act aca gac aca gac ggt gcc gcc      737
 Ile Asn Ile Asp Asp Glu Asp Ser Thr Thr Asp Thr Asp Gly Ala Ala
             120                 125                 130

 gag act tgt gtc tca gta cag tgt cag aag caa att aaa gaa ctt cga      785
 Glu Thr Cys Val Ser Val Gln Cys Gln Lys Gln Ile Lys Glu Leu Arg
         135                 140                 145

 gat caa att gta tct gtt cag gag gaa aag aag att tta gcc att gag      833
 Asp Gln Ile Val Ser Val Gln Glu Glu Lys Lys Ile Leu Ala Ile Glu
     150                 155                 160

 ctg gaa aat ctc aag agc aac tcg tag aagta attgaagaag taaataaagt      885
 Leu Glu Asn Leu Lys Ser Asn Ser 
 165                 170

 taaacaagaa aagactgttt taaattcaga agttcttgaa cagagaaaag tcttagaaaa    945

 atgcaataga gtgtccatgt tagctgtaga agagtatgag gagatgcaag taaacctgga   1005

 gctggagaag gaccttcgaa agaaagcaga gtcatttgca caagagatgt tcattgagca   1065

 aaacaagcta aagagacaaa gccaccttct gctgcagagc tccatccctg atcagcagct   1125

 tttgaaagct ttagacgaaa atgcaaaact cacccagcaa cttgaagaag agagaattca   1185

 gcatcaacaa aaggtcaaag aattagaaga gcaactagaa aatgaaacac tccacaaaga   1245

 aatacacaac ctcaaacagc aactggagct tctagaggaa gataaaaagg aattggaatt   1305

 gaaatatcag aattctgaag agaaagccag aaatttaaag cactctgttg atgaactcca   1365

 gaaacgagtg aaccagtctg agaattcagt acctccacca cctcctcctc caccaccact   1425

 tccccctcca cctcccaatc ctatccgatc cctcatgtcc atgatccgga aacgatccca   1485

 ccccagtggc agtggtgcta agaaagaaaa ggcaactcaa ccagaaacaa ctgaagaagt   1545

 cacagatcta aagaggcaag cagttgaaga gatgatggat agaattaaaa agggagttca   1605

 tcttagaccc gttaatcaga cagccagacc gaagacaaag ccagaatctt cgaaaggctg   1665

 cgaaagtgca gtggatgaac taaaaggaat actggcctcc cagtagcatt ggatgcagga   1725

 aaaaatacat tgacggtgaa aaacaagccg aaccagttgt agttttagat cctgtttcta   1785

 cacatgaacc ccaaaccaaa gaccaggttg ctgaaaaaga tccaactcaa cacaaggagg   1845

 atgaaggcga aattcaacca gaaaacaaag aagacagcat tgaaaacgtg agagagacag   1905

 acagctccaa ctgctgatcc ataaaccaga agcctgatat gtttggaagt ccttttcaat   1965

 aagcacatga ttagtgttgt tatattggca agggctgtag acattctgct ctggtcactg   2025

 tattcagaat acaggttctt ttctggtgtc acttttgtaa gtagcaacta taaacataag   2085

 taagctgttt agcaaaacac acattcctag taggttttgg ttttttgatc tttataaaga   2145

 tgaggttttt ttcctagtta ctgtattaag tatgacttct tttagaaggt tacaaaaaaa   2205

 ttcagatgtt gatacctttt taggaaatgt gcataccact catcaaatgg aatgctgaaa   2265

 gtttgaggtg cttgtatata atcggataaa caaaactgat caacccaatg tgattttaaa   2325

 agcccccaaa gaagcttctg ttttgggtct gatcctcttg atggagaaac tgcagcagca   2385

 tggaaattgt tgggtactgt ggcatacaag ttattttcta cagtagactg agataaactg   2445

 aaaactcagg agctggcatc aaactcgtag tcccatagtc agtgttaatt acacacattg   2505

 ttaactattg gatgaaaaat acatgctatt gattgtgtcc aaagcctccc gaggacctcc   2565

 gtggggatgc tctggtagcc tgaatacaga actgaggtga aagtccaaac cttgaatttt   2625

 acagtagtaa gttggtaaac catgtgctct gtgctatgag ttaattatgt tttcccaaat   2685

 actaatgtgg cacaagtacc atattttatc agagttctta tgtacagtat ggtgaagata   2745

 agtgacaagc acacattttt cttgcttcac tgctgttcta tattacacag gtttgttgtt   2805

 gtttttttta aaaaagaaat taagcagtag ttagtctcta aaaatacaat gtttcaggct   2865

 accacagtga ataaatagaa atgtaatcag ggattaaaaa aaaaacttat gcagcttttc   2925

 aaagttgatt gtttcaaaat tggtgtttat ttaaaataag tggtaatgta cttgaatgca   2985

 ctttttatga caatgattca gtaatggtaa ttttactatt aaagaaagtg aaaggtttag   3045

 ttttgttagc atggctcagc atgtagctgt caggtgtttt tcacctaagg gcaaaagaaa   3105

 atgatagtaa taattgcagt agttgtattg tattgtattt ttgcacgtgt ggtaagcata   3165

 ggcttgaaga ggtgggtagg caggtacatg tacttcctaa atttggagat aattatcttt   3225

 ctgtaagttc gttatgcttg actgtttcca tgttctccca ataatgattt tatagttact   3285

 tatcacttta ctcatggaga attaaaacgt aatgtttttc aactgtatct ttctttaact   3345

 ggataatact gctatatgat atgcttacta cagactgcat taattcacga aacgaattct   3405

 gttatgctgt aatttgaact ctcctcacca caacttatta aaaaggcacc aatagtttcc   3465

 caaaaaaaaa a                                                        3476




      <210> 494
      <211> 231
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(231)

      <400> 494
 tttcttataa tgccaacttt gtacaagaaa gctgggtcgg cgcgcccacc cttcacc        57                                                                 
 atg gtt tcg gcg gca gcc cca agt ctc ctc atc ctt ctg ttg ctg ctc      105
 Met Val Ser Ala Ala Ala Pro Ser Leu Leu Ile Leu Leu Leu Leu Leu
   1               5                  10                  15

 ctg ggg tct gtg cct gct acc gac gcc ctg ctg gaa ggg tct ctc ttg      153
 Leu Gly Ser Val Pro Ala Thr Asp Ala Leu Leu Glu Gly Ser Leu Leu
              20                  25                  30

 tta gcc cag gaa gcc cag gga cca gtg ggt ccc ccc gaa agc ccc tgt      201
 Leu Ala Gln Glu Ala Gln Gly Pro Val Gly Pro Pro Glu Ser Pro Cys
          35                  40                  45

 gct tgc agc agt gtc cac ccc agt gtc taa                              231
 Ala Cys Ser Ser Val His Pro Ser Val 
      50                  55





      <210> 495
      <211> 634
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(249)

      <400> 495
 cgcgcgacta cccgtgtggt ggaattcgtc atccccaatt ttaatagcct gctttttaaa     60

 aggtaatgcc tgtgaaatgg ttttgtcaca ttttct  atg ttc tgt tcc ttt cca     114
                                          Met Phe Cys Ser Phe Pro
                                            1               5

 ttg ctc att ttg caa gtg tat cct act tgg aaa aac cct aat tgg cat      162
 Leu Leu Ile Leu Gln Val Tyr Pro Thr Trp Lys Asn Pro Asn Trp His
              10                  15                  20

 cta act ttt cac acg agt gtg ttt tct ttt ccc aaa ggg gtt aga agt      210
 Leu Thr Phe His Thr Ser Val Phe Ser Phe Pro Lys Gly Val Arg Ser
          25                  30                  35

 ttg gct cgg gga atc cct gac cat ctc cac agt gcc tag cacggagtga       259
 Leu Ala Arg Gly Ile Pro Asp His Leu His Ser Ala 
      40                  45                  50

 acatttactg aatactgcta gcccatttgt agcagcatgg tcccctgccc tgtggattac    319

 ctcctgttca tgccctggct ggtctggcca tgtctggagc acctgtgtgg ttatgagaac    379

 cttggcaaat gaaggaccag gagcaggaga gctcttatga gatgaagttg aaggactaga    439

 ggctgaacta ctggggaggg accaaatggg atttgggact aatctgtcac atggggagtg    499

 taggcatcca ggtaaaagtg gcagcctgaa cacatgcagt ttttgttttt gtttgctcca    559

 tccccaagcc ccactgaatg aacagtaaag aggctgggcg cagtggccca tgcctgtaat    619

 cccagcgctt tggga                                                     634




      <210> 496
      <211> 678
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (221)..(589)

      <400> 496
 caagctggct agcgtttaaa cttaagcttg gtaccgagct cggatccact agtccagtgt     60

 ggtggaattc cactgtgtct ccaccacatc tttttgtgcc ctgggtctgc tcatgggagg    120

 cagcgttagg aaggaggcgg cctcactttt ttctgccttc cctttatcct gggcttttta    180

 gttccttggt tcccctcccc cctttccatt ccattcatag  atg cag cag atg atg     235
                                              Met Gln Gln Met Met
                                                1               5

 tgg gcg ggg ctg ctg tgc cca cag ttg gag tgg ctg cag ggg agg gca      283
 Trp Ala Gly Leu Leu Cys Pro Gln Leu Glu Trp Leu Gln Gly Arg Ala
                  10                  15                  20

 tgc agg ccg tgc ggc ctt ctg gct tca gat gct gct gcc ctg tgg ttc      331
 Cys Arg Pro Cys Gly Leu Leu Ala Ser Asp Ala Ala Ala Leu Trp Phe
              25                  30                  35

 cgt ggt ggc att tct gcc tgg gag gac tcc tgt gca gtt agc aac ata      379
 Arg Gly Gly Ile Ser Ala Trp Glu Asp Ser Cys Ala Val Ser Asn Ile
          40                  45                  50

 aga cat gaa gca tat aat tgt cac ttg tca gtc ttt tta aat cgc tgt      427
 Arg His Glu Ala Tyr Asn Cys His Leu Ser Val Phe Leu Asn Arg Cys
      55                  60                  65

 gca aat gaa tta aca gtt cag ttt ctt ata att tta gct ttc caa atc      475
 Ala Asn Glu Leu Thr Val Gln Phe Leu Ile Ile Leu Ala Phe Gln Ile
  70                  75                  80                  85

 atg ctt tcc tgt gct gtg ata gct cct gca gtc ccc gtt ttc cag aga      523
 Met Leu Ser Cys Ala Val Ile Ala Pro Ala Val Pro Val Phe Gln Arg
                  90                  95                 100

 ctg act ctc aag agg tct gga agg acc agc ctg ggc agc aca ggg agg      571
 Leu Thr Leu Lys Arg Ser Gly Arg Thr Ser Leu Gly Ser Thr Gly Arg
             105                 110                 115

 ctc cat ttc tgc aaa taa taaaac gagttagctg ggcgtagtgg cgcacacctg      625
 Leu His Phe Cys Lys 
         120

 tggtcccagc tacttgggag gctgaggtgg gaggatcact tgagcccagg agc           678




      <210> 497
      <211> 635
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(279)

      <400> 497
 aagcgaatag cccagtgtgg tggaattcac tgtgtatgca ataatgaccc attgtggttt     60

 ttaacttatc tc    atg aaa aga ctt agg ttt gtt ctc agg gta ttt cag     108
                  Met Lys Arg Leu Arg Phe Val Leu Arg Val Phe Gln
                    1               5                  10

 atg act gcc ttt ata act ggg gca cat acg att act aac tat agt gat      156
 Met Thr Ala Phe Ile Thr Gly Ala His Thr Ile Thr Asn Tyr Ser Asp
          15                  20                  25

 agg cgt tta tac att tcc cct ttg agc cat ttc ttt atg aac agt ggt      204
 Arg Arg Leu Tyr Ile Ser Pro Leu Ser His Phe Phe Met Asn Ser Gly
      30                  35                  40

 tct tct gct caa agt gtt ctg tct cat tct tat gtt tct caa atc ttc      252
 Ser Ser Ala Gln Ser Val Leu Ser His Ser Tyr Val Ser Gln Ile Phe
  45                  50                  55                  60

 ttt aaa aat gta agc aaa tat ttt taa agaat ttttatgttt tccaaaatta      304
 Phe Lys Asn Val Ser Lys Tyr Phe 
                  65

 ggattttaga ctttagggat tttgatcttt ggggatttca acattcggga ttatggtgtt    364

 cagtgtgtat tttgggggga ttatgatcag catcccatac agtggaatat catttggcaa    424

 taaaaaggaa ttaaatattg attcatgcta caacatggtg aacctaaaaa acattatgtt    484

 cagtgaaaga agccaaacct aaaaggccta cgtactgtgt ggttaaatgg taaaaatggt    544

 gaatttatca caatcaaaac caataaacct ctacaggaaa aaataaggac aaagaaaggc    604

 tgttccctat taatggagac taaagagaca a                                   635




      <210> 498
      <211> 2440
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (314)..(2392)

      <400> 498
 ccggaattcc cgggtcgacg atttcgtccc gccccgcgtg ctggccgcgg taaaagtggt     60

 agcagcggag gcgagcggag ggtttcccgc ggcggagtct cactctgctg cctaggctga    120

 gtgcagtggt gtgatcgagg cgcactgcag ccttgacctc ctgggctcaa gcgatcctca    180

 cctcggccta ccgagtagct gggactacag gcacgcgcca ctacactcgg atttctgaca    240

 gtcagacttg tccacaagaa ctcaactggc aaggctgctt ttctgtgcta aaactgggga    300

 gctagtgggc acc   atg aag atc ttc tgc agt cgg gcc aat ccg acc acg     349
                  Met Lys Ile Phe Cys Ser Arg Ala Asn Pro Thr Thr
                    1               5                  10

 ggg tct gtg gag tgg ctg gag gag gat gaa cac tat gat tac cac cag      397
 Gly Ser Val Glu Trp Leu Glu Glu Asp Glu His Tyr Asp Tyr His Gln
          15                  20                  25

 gag att gca agg tca tct tat gca gat atg cta cat gac aaa gac aga      445
 Glu Ile Ala Arg Ser Ser Tyr Ala Asp Met Leu His Asp Lys Asp Arg
      30                  35                  40

 aat gta aaa tac tac caa ggt atc cgg gct gcc gtg agc agg gtg aag      493
 Asn Val Lys Tyr Tyr Gln Gly Ile Arg Ala Ala Val Ser Arg Val Lys
  45                  50                  55                  60

 gac aga gga cag aag gcc ttg gtt ctc gac att ggc act ggc acg gga      541
 Asp Arg Gly Gln Lys Ala Leu Val Leu Asp Ile Gly Thr Gly Thr Gly
                  65                  70                  75

 ctc ttg tca atg atg gcg gtc aca gca ggt gcc gac ttc tgc tat gcc      589
 Leu Leu Ser Met Met Ala Val Thr Ala Gly Ala Asp Phe Cys Tyr Ala
              80                  85                  90

 atc gag gtt ttc aag cct atg gct gat gct gct gtg aag att gtg gag      637
 Ile Glu Val Phe Lys Pro Met Ala Asp Ala Ala Val Lys Ile Val Glu
          95                 100                 105

 aaa aat ggc ttt agt gat aag att aag gtt atc aac aag cat tcc acc      685
 Lys Asn Gly Phe Ser Asp Lys Ile Lys Val Ile Asn Lys His Ser Thr
     110                 115                 120

 gag gtg act gta ggt cca gag ggt gac atg cca tgc cgt gcc aac atc      733
 Glu Val Thr Val Gly Pro Glu Gly Asp Met Pro Cys Arg Ala Asn Ile
 125                 130                 135                 140

 ctg gtc aca gag ttg ttt gac aca gag ctg atc ggg gag ggg gcg ctg      781
 Leu Val Thr Glu Leu Phe Asp Thr Glu Leu Ile Gly Glu Gly Ala Leu
                 145                 150                 155

 ccc tcc tat gag cac gca cac agg cat ctc gtg gag gaa aat tgt gag      829
 Pro Ser Tyr Glu His Ala His Arg His Leu Val Glu Glu Asn Cys Glu
             160                 165                 170

 gcc gtg ccc cac aga gcc acc gtc tat gca cag ctg gtg gag tcc ggg      877
 Ala Val Pro His Arg Ala Thr Val Tyr Ala Gln Leu Val Glu Ser Gly
         175                 180                 185

 agg atg tgg tcg tgg aac aag cta ttt ccc atc cac gtg cag acc agc      925
 Arg Met Trp Ser Trp Asn Lys Leu Phe Pro Ile His Val Gln Thr Ser
     190                 195                 200

 ctc gga gag cag gtc atc gtc cct ccc gtt gac gtg gag agc tgc cct      973
 Leu Gly Glu Gln Val Ile Val Pro Pro Val Asp Val Glu Ser Cys Pro
 205                 210                 215                 220

 ggc gca ccc tct gtc tgt gac att cag ctg aac cag gtg tca cca gcc     1021
 Gly Ala Pro Ser Val Cys Asp Ile Gln Leu Asn Gln Val Ser Pro Ala
                 225                 230                 235

 gac ttt aca gtc ctc agc gat gtg ctg ccc atg ttc agc ata gac ttc     1069
 Asp Phe Thr Val Leu Ser Asp Val Leu Pro Met Phe Ser Ile Asp Phe
             240                 245                 250

 agc aag caa gtc agt agc tca gca gcc tgc cat agc agg cgg ttt gaa     1117
 Ser Lys Gln Val Ser Ser Ser Ala Ala Cys His Ser Arg Arg Phe Glu
         255                 260                 265

 cct ctg aca tct ggc cga gct cag gtg gtt ctc tcg tgg tgg gac att     1165
 Pro Leu Thr Ser Gly Arg Ala Gln Val Val Leu Ser Trp Trp Asp Ile
     270                 275                 280

 gaa atg gac cct gag ggg aag atc aag tgc acc atg gcc ccc ttc tgg     1213
 Glu Met Asp Pro Glu Gly Lys Ile Lys Cys Thr Met Ala Pro Phe Trp
 285                 290                 295                 300

 gca cac tca gac cca gag gag atg cag tgg cgg gac cac tgg atg cag     1261
 Ala His Ser Asp Pro Glu Glu Met Gln Trp Arg Asp His Trp Met Gln
                 305                 310                 315

 tgt gtg tac ttc ctg cca caa gag gag cct gtg gtg cag ggc tca gcg     1309
 Cys Val Tyr Phe Leu Pro Gln Glu Glu Pro Val Val Gln Gly Ser Ala
             320                 325                 330

 ctc tat ctg gta gcc cac cac gat gac tac tgc gta tgg tac agc ctg     1357
 Leu Tyr Leu Val Ala His His Asp Asp Tyr Cys Val Trp Tyr Ser Leu
         335                 340                 345

 cag agg acc agc cct gaa aag aat gag aga gtc cgc cag atg cgc ccc     1405
 Gln Arg Thr Ser Pro Glu Lys Asn Glu Arg Val Arg Gln Met Arg Pro
     350                 355                 360

 gtg tgt gac tgc cag gct cac ctg ctc tgg aac cgg cct cgg ttt gga     1453
 Val Cys Asp Cys Gln Ala His Leu Leu Trp Asn Arg Pro Arg Phe Gly
 365                 370                 375                 380

 gag atc aat gac cag gac aga act gat cga tac gtc cag gct ctg agg     1501
 Glu Ile Asn Asp Gln Asp Arg Thr Asp Arg Tyr Val Gln Ala Leu Arg
                 385                 390                 395

 acc gtg ctg aag cca gac agc gtg tgc ctg tgt gtc agc gat ggc agc     1549
 Thr Val Leu Lys Pro Asp Ser Val Cys Leu Cys Val Ser Asp Gly Ser
             400                 405                 410

 ctg ctc tcc gtg ctg gcc cat cac ctg ggg gtg gag cag gtg ttt aca     1597
 Leu Leu Ser Val Leu Ala His His Leu Gly Val Glu Gln Val Phe Thr
         415                 420                 425

 gtc gag agt tca gca gct tct cac aaa ctg ttg aga aaa atc ttc aag     1645
 Val Glu Ser Ser Ala Ala Ser His Lys Leu Leu Arg Lys Ile Phe Lys
     430                 435                 440

 gct aac cac ttg gaa gat aaa att aac atc ata gag aaa cgg ccg gaa     1693
 Ala Asn His Leu Glu Asp Lys Ile Asn Ile Ile Glu Lys Arg Pro Glu
 445                 450                 455                 460

 tta tta aca aat gag gac cta cag ggc aga aag gtc tct ctc ctc ctg     1741
 Leu Leu Thr Asn Glu Asp Leu Gln Gly Arg Lys Val Ser Leu Leu Leu
                 465                 470                 475

 ggc gag ccg ttc ttc act acc agc ctg ctg ccg tgg cac aac ctc tac     1789
 Gly Glu Pro Phe Phe Thr Thr Ser Leu Leu Pro Trp His Asn Leu Tyr
             480                 485                 490

 ttc tgg tac gtg cgg acc gct gtg gac cag cac ctg ggg cca ggt gcc     1837
 Phe Trp Tyr Val Arg Thr Ala Val Asp Gln His Leu Gly Pro Gly Ala
         495                 500                 505

 atg gtg atg ccc cag gca gcc tcg ctg cac gct gtg gtt gtg gag ttc     1885
 Met Val Met Pro Gln Ala Ala Ser Leu His Ala Val Val Val Glu Phe
     510                 515                 520

 agg gac ctg tgg cgg atc cgg agc ccc tgt ggt gac tgc gaa ggc ttc     1933
 Arg Asp Leu Trp Arg Ile Arg Ser Pro Cys Gly Asp Cys Glu Gly Phe
 525                 530                 535                 540

 gac gtg cac atc atg gac gac atg att aag cgt gcc ctg gac ttc agg     1981
 Asp Val His Ile Met Asp Asp Met Ile Lys Arg Ala Leu Asp Phe Arg
                 545                 550                 555

 gag agc agg gaa gct gag ccc cac ccg ctg tgg gag tac cca tgc cgc     2029
 Glu Ser Arg Glu Ala Glu Pro His Pro Leu Trp Glu Tyr Pro Cys Arg
             560                 565                 570

 agc ctc tcc gag ccc tgg cag atc ctg acc ttt gac ttc cag cag ccg     2077
 Ser Leu Ser Glu Pro Trp Gln Ile Leu Thr Phe Asp Phe Gln Gln Pro
         575                 580                 585

 gtg ccc ctg cag ccc ctg tgt gcc gag ggc acc gtg gag ctc aga agg     2125
 Val Pro Leu Gln Pro Leu Cys Ala Glu Gly Thr Val Glu Leu Arg Arg
     590                 595                 600

 ccc ggg cag agc cac gca gcg gtg cta tgg atg gag tac cac ctg acc     2173
 Pro Gly Gln Ser His Ala Ala Val Leu Trp Met Glu Tyr His Leu Thr
 605                 610                 615                 620

 ccg gag tgc acg ctc agc act ggc ctc ctg gag cct gca gac ccc gag     2221
 Pro Glu Cys Thr Leu Ser Thr Gly Leu Leu Glu Pro Ala Asp Pro Glu
                 625                 630                 635

 ggg ggc tgc tgc tgg aac ccc cac tgc aag cag gcc gtc tac ttc ttc     2269
 Gly Gly Cys Cys Trp Asn Pro His Cys Lys Gln Ala Val Tyr Phe Phe
             640                 645                 650

 agc cct gcc cca gat ccc aga gca ctg ctg ggt ggc cca cgg act gtc     2317
 Ser Pro Ala Pro Asp Pro Arg Ala Leu Leu Gly Gly Pro Arg Thr Val
         655                 660                 665

 agc tat gca gtg gag ttt cac ccc gac aca ggc gac atc atc atg gag     2365
 Ser Tyr Ala Val Glu Phe His Pro Asp Thr Gly Asp Ile Ile Met Glu
     670                 675                 680

 ttc agg cat gca gat acc cca gac tga ccact cttgagcaat aaagtggcct     2417
 Phe Arg His Ala Asp Thr Pro Asp 
 685                 690

 gagggctggg aaaaaaaaaa aaa                                           2440




      <210> 499
      <211> 2555
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (23)..(1429)

      <400> 499
 gcgctgagaa ggagcagaca ag atg gcg acg tcc gtg ggg cac cga tgt ctg      52
                          Met Ala Thr Ser Val Gly His Arg Cys Leu
                            1               5                  10

 gga tta ctg cac ggg gtc gcg ccg tgg cgg agc agc ctc cat ccc tgt      100
 Gly Leu Leu His Gly Val Ala Pro Trp Arg Ser Ser Leu His Pro Cys
                  15                  20                  25

 gag atc act gcc ctg agc caa tcc cta cag ccc tta cgg aag ctg cct      148
 Glu Ile Thr Ala Leu Ser Gln Ser Leu Gln Pro Leu Arg Lys Leu Pro
              30                  35                  40

 ttt aga gcc ttt cgc aca gat gcc aga aaa atc cac act gcc cct gcc      196
 Phe Arg Ala Phe Arg Thr Asp Ala Arg Lys Ile His Thr Ala Pro Ala
          45                  50                  55

 cga acc atg ttc ctg ctg cgt ccc ctg ccc att ctg ttg gtg aca ggc      244
 Arg Thr Met Phe Leu Leu Arg Pro Leu Pro Ile Leu Leu Val Thr Gly
      60                  65                  70

 ggc ggg tat gca ggg tac cgg cag tat gag aag tac agg gag cga gag      292
 Gly Gly Tyr Ala Gly Tyr Arg Gln Tyr Glu Lys Tyr Arg Glu Arg Glu
  75                  80                  85                  90

 ctg gag aag ctg gga ttg gag att cca ccc aaa ctt gct ggt cac tgg      340
 Leu Glu Lys Leu Gly Leu Glu Ile Pro Pro Lys Leu Ala Gly His Trp
                  95                 100                 105

 gag gtg gct ttg tac aag tca gtg cca acg cgc ttg ctg tca cgg gcc      388
 Glu Val Ala Leu Tyr Lys Ser Val Pro Thr Arg Leu Leu Ser Arg Ala
             110                 115                 120

 tgg ggt cgc ctc aat cag gtg gag ctg cca cac tgg ctg cgc agg ccc      436
 Trp Gly Arg Leu Asn Gln Val Glu Leu Pro His Trp Leu Arg Arg Pro
         125                 130                 135

 gtc tac agc ctg tac atc tgg acg ttt ggg gtg aac atg aaa gag gcc      484
 Val Tyr Ser Leu Tyr Ile Trp Thr Phe Gly Val Asn Met Lys Glu Ala
     140                 145                 150

 gct gtg gag gac ctg cat cac tac cgc aac ctc agc gag ttc ttc cgg      532
 Ala Val Glu Asp Leu His His Tyr Arg Asn Leu Ser Glu Phe Phe Arg
 155                 160                 165                 170

 cgc aag ctg aag ccg cag gcc cgg cct gtc tgt ggc ctg cac agc gtg      580
 Arg Lys Leu Lys Pro Gln Ala Arg Pro Val Cys Gly Leu His Ser Val
                 175                 180                 185

 gtg agg cct gac cct ttc ctc ctg cag gaa aca gga ctt ttt cct gcc      628
 Val Arg Pro Asp Pro Phe Leu Leu Gln Glu Thr Gly Leu Phe Pro Ala
             190                 195                 200

 tcc cca gca cag ccc ccc tgg tct cca gcg tat ctg gaa ggg gca gga      676
 Ser Pro Ala Gln Pro Pro Trp Ser Pro Ala Tyr Leu Glu Gly Ala Gly
         205                 210                 215

 atg aca agg gga ggt ggg ggc tgt ctc ctg ggg gga gga gac cct gct      724
 Met Thr Arg Gly Gly Gly Gly Cys Leu Leu Gly Gly Gly Asp Pro Ala
     220                 225                 230

 ctc cct ggc agc aag cct ctc ctg ccc ttc cag att agc cca tcg gat      772
 Leu Pro Gly Ser Lys Pro Leu Leu Pro Phe Gln Ile Ser Pro Ser Asp
 235                 240                 245                 250

 gga agg atc ctc aac ttt ggg cag gtg aag aac tgt gag gtg gag cag      820
 Gly Arg Ile Leu Asn Phe Gly Gln Val Lys Asn Cys Glu Val Glu Gln
                 255                 260                 265

 gta aag ggg gtc acc tac tcc ctg gag tcg ttc ctg ggc ccg cgt atg      868
 Val Lys Gly Val Thr Tyr Ser Leu Glu Ser Phe Leu Gly Pro Arg Met
             270                 275                 280

 tgc aca gag gac ctg ccc ttc cca cca gcc gcg tcg tgt gac tcc ttc      916
 Cys Thr Glu Asp Leu Pro Phe Pro Pro Ala Ala Ser Cys Asp Ser Phe
         285                 290                 295

 aag aac cag ctg gtc acc cgg gaa ggg aat gag ctc tat cac tgt gtc      964
 Lys Asn Gln Leu Val Thr Arg Glu Gly Asn Glu Leu Tyr His Cys Val
     300                 305                 310

 atc tac ctg gcc cct ggg gac tac cac tgc ttc cac tcc ccc acc gac     1012
 Ile Tyr Leu Ala Pro Gly Asp Tyr His Cys Phe His Ser Pro Thr Asp
 315                 320                 325                 330

 tgg act gtg tcc cac cgg cgc cac ttc cca ggc tcc ctg atg tca gtg     1060
 Trp Thr Val Ser His Arg Arg His Phe Pro Gly Ser Leu Met Ser Val
                 335                 340                 345

 aac cct ggc atg gct cgc tgg atc aaa gag ctc ttc tgc cat aac gag     1108
 Asn Pro Gly Met Ala Arg Trp Ile Lys Glu Leu Phe Cys His Asn Glu
             350                 355                 360

 cgg gtg gtc ctg acg ggg gac tgg aaa cat ggc ttc ttc tca ctg aca     1156
 Arg Val Val Leu Thr Gly Asp Trp Lys His Gly Phe Phe Ser Leu Thr
         365                 370                 375

 gct gtg ggg gcc acc aac gtg ggc tcc att cgc atc tac ttt gac cgg     1204
 Ala Val Gly Ala Thr Asn Val Gly Ser Ile Arg Ile Tyr Phe Asp Arg
     380                 385                 390

 gac ctg cac aca aac agc cca agg cac agc aag ggc tcc tac aat gac     1252
 Asp Leu His Thr Asn Ser Pro Arg His Ser Lys Gly Ser Tyr Asn Asp
 395                 400                 405                 410

 ttc agc ttt gtg acg cac acc aat aga gag ggc gtc ccc atg cgt aag     1300
 Phe Ser Phe Val Thr His Thr Asn Arg Glu Gly Val Pro Met Arg Lys
                 415                 420                 425

 ggc gag cac ctg ggc gag ttc aac ctg ggc tcc acc atc gtg ctc atc     1348
 Gly Glu His Leu Gly Glu Phe Asn Leu Gly Ser Thr Ile Val Leu Ile
             430                 435                 440

 ttc gag gcc ccc aag gac ttc aat ttc cag ctg aaa aca gga cag aaa     1396
 Phe Glu Ala Pro Lys Asp Phe Asn Phe Gln Leu Lys Thr Gly Gln Lys
         445                 450                 455

 atc cgc ttt ggg gaa gcc ctg ggc tcg ctc tag agtctctt tcctgattat     1447
 Ile Arg Phe Gly Glu Ala Leu Gly Ser Leu 
     460                 465

 ggctgctaag ggatcttttc caaacagagt gagggtcttt tcaagaggga ggcccatgag   1507

 gccatccagg taagggcctg cctcagcgtg gttgggagtc tgaccaggta ggacttgaat   1567

 gattcggctc ccacctgttc cagaggtgca gacaagaggt ggcgagagcc cccgtcatgc   1627

 ccctcaacct atcccgttcc ttctgcctac aaataaaaag tgcaggctgg aatgatctca   1687

 gtcacatttg gatcttttta aacactgtat agacggaaga gcctgcattc ctgaccgaac   1747

 cttcagttgg tctcggttgt cgttttttct tgctgctcct ccccccatca cctgagctgt   1807

 tttctgttgg ccccttttgt tttttggcct taacgctcct gctgcacagg gtgaggtacc   1867

 tccttggcac agactgtgga tgcctctccc ccagcagagc cacacagcct tcgtgacaac   1927

 tgctttccgt tcccacattc acctcatcct gctctttaga aaaagcagtt tttgtgcttg   1987

 tggctgaacg catcaccctg gactctgcta gtgtcttctg aggacactga tgacactgat   2047

 taatgataca gacctttgca ggacctgatg agtgaccctt ctggagctgg ccaggtcctc   2107

 tgcagcaggc aagaccaatc aatcactgaa cctgcctcat ggcaccagag tgaacagggc   2167

 aggcaggtag taggcccagc tggggaaatg ggagagttcc tgtccccctc cacatatccc   2227

 tacatgaaat atgggaaagt tgctgctatt gattcagggt ctgtcttgga ggcagaggac   2287

 ccttggtgga tagttggtca gtgcctggaa aacctgtccc agtttatcag gaacgcaggc   2347

 ctggggagcc cccagtggcg gggacagggc cagatttcat gttgaccctg gggatgctgt   2407

 gaatttctcc tgcaggagag acatcattga attttttcaa ctgtatcagt agcacagtat   2467

 ttttgtatga aaagtgggag acttctgaac agtaattcat ttaattgcaa agcattttga   2527

 aataaaaaaa atcaaactta aaaaaaaa                                      2555




      <210> 500
      <211> 1451
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (370)..(1191)

      <400> 500
 gctccacagg tccgccccaa tccccgctca cacttgggaa acttgtgact gcgctggggc     60

 cgcgtgtggc acctcagggg ggcggccccc ggcctcaaga ggagggggag gagaaggagg    120

 aagaggagga agtgagcccg aaggatccgc tcggagctgt ttgtccagct gtttctattc    180

 gcacccggag cagtacagcc agaagggggc cgagccgaag gtggctggct ttaggcgcta    240

 atttccaact cttttcctca cagcttgtct tttccaggca ccctggagtc ccctcaggcc    300

 agctcggtgg gcgcgcacct gccagccgcc cctgacctcg caggccaggc gacctccgag    360

 cctgagaag    atg gcc cag tcc aag ctc gat tgc cgc tca cct gtc ggc     408
              Met Ala Gln Ser Lys Leu Asp Cys Arg Ser Pro Val Gly
                1               5                  10

 ctc gac tgc tgc aac tgc tgc ctg gac ctg gcc cat cgg agt ggg ctc      456
 Leu Asp Cys Cys Asn Cys Cys Leu Asp Leu Ala His Arg Ser Gly Leu
      15                  20                  25

 cag cga ggc agc agc ggg gag aac aac aac ccg ggc agc cct aca gtg      504
 Gln Arg Gly Ser Ser Gly Glu Asn Asn Asn Pro Gly Ser Pro Thr Val
  30                  35                  40                  45

 agc aac ttt cgg cag ctg cag gaa aag ctg gtc ttt gag aac ctc aat      552
 Ser Asn Phe Arg Gln Leu Gln Glu Lys Leu Val Phe Glu Asn Leu Asn
                  50                  55                  60

 acc gac aag ctc aac agc ata atg cgg cag gat tcg cta gag ccg gtg      600
 Thr Asp Lys Leu Asn Ser Ile Met Arg Gln Asp Ser Leu Glu Pro Val
              65                  70                  75

 ctg cgg gac ccc tgc tac ctg atc aac gag ggc atc tgc aac cgc aac      648
 Leu Arg Asp Pro Cys Tyr Leu Ile Asn Glu Gly Ile Cys Asn Arg Asn
          80                  85                  90

 atc gac cag acc atg ctc tcc atc ctg ctc ttc ttc cac agt gcc tcc      696
 Ile Asp Gln Thr Met Leu Ser Ile Leu Leu Phe Phe His Ser Ala Ser
      95                 100                 105

 gga gcc agc gtg gtg gcc ata gac aac aag atc gaa cag gcc atg gat      744
 Gly Ala Ser Val Val Ala Ile Asp Asn Lys Ile Glu Gln Ala Met Asp
 110                 115                 120                 125

 ctg gtg aag aat cat ctg atg tat gct gtg aga gag gag gtg gag atc      792
 Leu Val Lys Asn His Leu Met Tyr Ala Val Arg Glu Glu Val Glu Ile
                 130                 135                 140

 ctg aag gag cag atc cga gag ctg gtg gag aag aac tcc cag cta gag      840
 Leu Lys Glu Gln Ile Arg Glu Leu Val Glu Lys Asn Ser Gln Leu Glu
             145                 150                 155

 cgt gag aac acc ctg ttg aag acc ctg gca agc cca gag cag ctg gag      888
 Arg Glu Asn Thr Leu Leu Lys Thr Leu Ala Ser Pro Glu Gln Leu Glu
         160                 165                 170

 aag ttc cag tcc tgt ctg agc cct gaa gag cca gct ccc gaa tcc cca      936
 Lys Phe Gln Ser Cys Leu Ser Pro Glu Glu Pro Ala Pro Glu Ser Pro
     175                 180                 185

 caa gtg ccc gag gcc cct ggt ggt tct gcg ggt gaa gtg gct ctg tcc      984
 Gln Val Pro Glu Ala Pro Gly Gly Ser Ala Gly Glu Val Ala Leu Ser
 190                 195                 200                 205

 tca ggg tgg gca gag cca cta aac ttg ttt tac cta gtt ctt tcc agt     1032
 Ser Gly Trp Ala Glu Pro Leu Asn Leu Phe Tyr Leu Val Leu Ser Ser
                 210                 215                 220

 ttg ttt ttg gct ccc caa gca tca tct cac gag gag aac ttt aca cct     1080
 Leu Phe Leu Ala Pro Gln Ala Ser Ser His Glu Glu Asn Phe Thr Pro
             225                 230                 235

 agc aca gct ggt gcc aag aga tgt cct aag gac att ggc cac ctg ggt     1128
 Ser Thr Ala Gly Ala Lys Arg Cys Pro Lys Asp Ile Gly His Leu Gly
         240                 245                 250

 cca ctc cag cga cag acc cct gac aag agc agg tct ctg gag gct gag     1176
 Pro Leu Gln Arg Gln Thr Pro Asp Lys Ser Arg Ser Leu Glu Ala Glu
     255                 260                 265

 ttg cat ggg gcc tag taacaccaag ccagttagcc tctaatgcta ctgcgccctg     1231
 Leu His Gly Ala 
 270

 gggctcccag gcctgggcaa cttagctgca cttgcaaaga agaagggtag tttgagtgta   1291

 cacaggttgc tcagaagttt aggggtctgt tctcatctca tggcatctca cagctcactg   1351

 acacgactct ctattagagc actgtgttta gagagcacct ctttctctct ctgttcgtaa   1411

 gcagggcaaa atggagaatt accagtcagc tctttggtat                         1451




      <210> 501
      <211> 4917
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (161)..(2122)

      <400> 501
 cttataagtg cttaaggaag agtgatgaag ataggcatga agccttcgtc tcacagctgc     60

 atgcgtagtc actgttgaag caaatgccta cctaatttga cactcttggt gtgtttaaaa    120

 aaattttttg agtttgcaaa taagcatatt aagtctactg  atg gag cct tcg ggc     175
                                              Met Glu Pro Ser Gly
                                                1               5

 agt gaa cag tta ttt gag gac cct gat cct gga ggc aaa tcc caa gat      223
 Ser Glu Gln Leu Phe Glu Asp Pro Asp Pro Gly Gly Lys Ser Gln Asp
                  10                  15                  20

 gca gag gcc aga aag cag aca gaa tca gaa caa aaa ttg tct aaa atg      271
 Ala Glu Ala Arg Lys Gln Thr Glu Ser Glu Gln Lys Leu Ser Lys Met
              25                  30                  35

 acc cac aat gct ttg gag aac att aac gtg att ggc caa ggc ttg aag      319
 Thr His Asn Ala Leu Glu Asn Ile Asn Val Ile Gly Gln Gly Leu Lys
          40                  45                  50

 cat ctc ttc cag cac cag cgc agg agg tca tca gtg tct cca cat gat      367
 His Leu Phe Gln His Gln Arg Arg Arg Ser Ser Val Ser Pro His Asp
      55                  60                  65

 gtg cag caa att cag gca gat cca gaa cct gaa atg gat ctg gaa agc      415
 Val Gln Gln Ile Gln Ala Asp Pro Glu Pro Glu Met Asp Leu Glu Ser
  70                  75                  80                  85

 cag aac gca tgt gct gag att gat ggt gtc ccc acc cac ccc aca gct      463
 Gln Asn Ala Cys Ala Glu Ile Asp Gly Val Pro Thr His Pro Thr Ala
                  90                  95                 100

 ctg aat cgt gtc ctg cag cag att cga gtg cca ccc aag atg aag aga      511
 Leu Asn Arg Val Leu Gln Gln Ile Arg Val Pro Pro Lys Met Lys Arg
             105                 110                 115

 ggg aca agc ttg cat agt agg cgg ggc aag cca gag gcc cca aag gga      559
 Gly Thr Ser Leu His Ser Arg Arg Gly Lys Pro Glu Ala Pro Lys Gly
         120                 125                 130

 agt ccc caa atc aac agg aag tct ggt cag gag atg aca gct gtt atg      607
 Ser Pro Gln Ile Asn Arg Lys Ser Gly Gln Glu Met Thr Ala Val Met
     135                 140                 145

 cag tca ggc cga ccc agg tct tca tcc aca act gat gca cct acc ggc      655
 Gln Ser Gly Arg Pro Arg Ser Ser Ser Thr Thr Asp Ala Pro Thr Gly
 150                 155                 160                 165

 tct gct atg atg gaa ata gct tgt gct gct gct gct gct gct gct gca      703
 Ser Ala Met Met Glu Ile Ala Cys Ala Ala Ala Ala Ala Ala Ala Ala
                 170                 175                 180

 tgt cta cca gga gag gag gga act gcg gag cgg atc gaa cgg ttg gaa      751
 Cys Leu Pro Gly Glu Glu Gly Thr Ala Glu Arg Ile Glu Arg Leu Glu
             185                 190                 195

 gta agc agc ctt gcc caa aca tcc agt gca gtg gcc tcc agt acc gat      799
 Val Ser Ser Leu Ala Gln Thr Ser Ser Ala Val Ala Ser Ser Thr Asp
         200                 205                 210

 ggc agc atc cac aca gac tct gtg gat gga aca cca gac cct cag cgc      847
 Gly Ser Ile His Thr Asp Ser Val Asp Gly Thr Pro Asp Pro Gln Arg
     215                 220                 225

 aca aag gct gcc att gct cac ctg cag cag aag atc ctg aag ctc aca      895
 Thr Lys Ala Ala Ile Ala His Leu Gln Gln Lys Ile Leu Lys Leu Thr
 230                 235                 240                 245

 gaa caa atc aag att gca caa aca gcc cgg gac gac aac gtt gct gaa      943
 Glu Gln Ile Lys Ile Ala Gln Thr Ala Arg Asp Asp Asn Val Ala Glu
                 250                 255                 260

 tac ttg aag ctt gcc aac agt gca gac aaa cag cag gct gcc cgc atc      991
 Tyr Leu Lys Leu Ala Asn Ser Ala Asp Lys Gln Gln Ala Ala Arg Ile
             265                 270                 275

 aag caa gtc ttt gag aag aag aac cag aaa tct gcc caa act atc ctc     1039
 Lys Gln Val Phe Glu Lys Lys Asn Gln Lys Ser Ala Gln Thr Ile Leu
         280                 285                 290

 cag ctg caa aag aaa ctt gag cac tac cac agg aag ctc aga gag gta     1087
 Gln Leu Gln Lys Lys Leu Glu His Tyr His Arg Lys Leu Arg Glu Val
     295                 300                 305

 gag cag aat ggg atc ccc cgg cag cca aag gat gtc ttc agg gac atg     1135
 Glu Gln Asn Gly Ile Pro Arg Gln Pro Lys Asp Val Phe Arg Asp Met
 310                 315                 320                 325

 cac cag ggt ctg aag gat gta gga gca aag gtg act ggc ttc agt gaa     1183
 His Gln Gly Leu Lys Asp Val Gly Ala Lys Val Thr Gly Phe Ser Glu
                 330                 335                 340

 ggt gtg gtg gat agt gtc aaa ggt ggg ttt tcc agc ttc tcc cag gcc     1231
 Gly Val Val Asp Ser Val Lys Gly Gly Phe Ser Ser Phe Ser Gln Ala
             345                 350                 355

 acc cat tca gca gca ggc gct gta gtc tca aag ccc aga gag att gcc     1279
 Thr His Ser Ala Ala Gly Ala Val Val Ser Lys Pro Arg Glu Ile Ala
         360                 365                 370

 tca ctc att cgg aac aaa ttt ggc agt gca gac aac atc ccc aac ctg     1327
 Ser Leu Ile Arg Asn Lys Phe Gly Ser Ala Asp Asn Ile Pro Asn Leu
     375                 380                 385

 aag gac tct tta gag gaa ggg caa gtg gat gat gcg ggg aag gct ttg     1375
 Lys Asp Ser Leu Glu Glu Gly Gln Val Asp Asp Ala Gly Lys Ala Leu
 390                 395                 400                 405

 gga gtg att tca aac ttt cag tct agc cca aaa tat ggt agt gaa gaa     1423
 Gly Val Ile Ser Asn Phe Gln Ser Ser Pro Lys Tyr Gly Ser Glu Glu
                 410                 415                 420

 gat tgt tct agt gcc act tca ggc tca gtg gga gcc aac agc acc aca     1471
 Asp Cys Ser Ser Ala Thr Ser Gly Ser Val Gly Ala Asn Ser Thr Thr
             425                 430                 435

 ggg ggc atc gct gta gga gca tcc agc tcc aaa aca aac acc ctg gac     1519
 Gly Gly Ile Ala Val Gly Ala Ser Ser Ser Lys Thr Asn Thr Leu Asp
         440                 445                 450

 atg cag agc tca gga ttt gat gca cta cta cat gag atc cag gag atc     1567
 Met Gln Ser Ser Gly Phe Asp Ala Leu Leu His Glu Ile Gln Glu Ile
     455                 460                 465

 cgg gaa acc cag gcc aga cta gag gaa tcc ttt gag act ctc aag gaa     1615
 Arg Glu Thr Gln Ala Arg Leu Glu Glu Ser Phe Glu Thr Leu Lys Glu
 470                 475                 480                 485

 cat tat cag agg gac tat tcc tta ata atg cag acc tta cag gag gag     1663
 His Tyr Gln Arg Asp Tyr Ser Leu Ile Met Gln Thr Leu Gln Glu Glu
                 490                 495                 500

 cga tat aga tgt gaa cga ttg gaa gaa cag cta aat gac cta aca gag     1711
 Arg Tyr Arg Cys Glu Arg Leu Glu Glu Gln Leu Asn Asp Leu Thr Glu
             505                 510                 515

 ctc cac cag aat gaa atc ttg aac ttg aag cag gaa ctg gca agc atg     1759
 Leu His Gln Asn Glu Ile Leu Asn Leu Lys Gln Glu Leu Ala Ser Met
         520                 525                 530

 gaa gaa aaa atc gcg tat cag tcc tat gaa cgg gcc cgg gac atc cag     1807
 Glu Glu Lys Ile Ala Tyr Gln Ser Tyr Glu Arg Ala Arg Asp Ile Gln
     535                 540                 545

 gag gcc ctg gag gca tgc cag acg cgc atc tcc aag atg gag ctg cag     1855
 Glu Ala Leu Glu Ala Cys Gln Thr Arg Ile Ser Lys Met Glu Leu Gln
 550                 555                 560                 565

 cag cag cag cag cag gtg gtg cag cta gaa ggg ctg gag aat gcc act     1903
 Gln Gln Gln Gln Gln Val Val Gln Leu Glu Gly Leu Glu Asn Ala Thr
                 570                 575                 580

 gcc cgg aac ctt ctg ggc aaa ctc atc aac atc ctc ctg gct gtc atg     1951
 Ala Arg Asn Leu Leu Gly Lys Leu Ile Asn Ile Leu Leu Ala Val Met
             585                 590                 595

 gca gtc ctt ttg gtc ttt gtc tcc act gta gcc aac tgt gtg gtc ccc     1999
 Ala Val Leu Leu Val Phe Val Ser Thr Val Ala Asn Cys Val Val Pro
         600                 605                 610

 ctc atg aag act cgc aac agg acg ttc agc act tta ttc ctt gtg gtt     2047
 Leu Met Lys Thr Arg Asn Arg Thr Phe Ser Thr Leu Phe Leu Val Val
     615                 620                 625

 ttt att gcc ttt ctc tgg aag cac tgg gac gcc ctc ttc agc tat gtg     2095
 Phe Ile Ala Phe Leu Trp Lys His Trp Asp Ala Leu Phe Ser Tyr Val
 630                 635                 640                 645

 gaa cgg ttc ttt tca tcc cct aga tga tgctg gcacagaagg cattgttccc     2147
 Glu Arg Phe Phe Ser Ser Pro Arg 
                 650

 taccctctgg cgagtgcatg cagcagagag ttagacagca acttacctac tctgaagttt   2207

 tctacaacaa aaaaagagtt gagtgaatct gtttacattt agaataatgt ttttttcttc   2267

 aagagacgca attgcaatag tattttttag attttatcca agaagttttt tgggcgaaaa   2327

 tcttggatca tttttatgta gcatgatttt ccttgggatg caaatcttaa aacagtcctt   2387

 taatatgaac caacaatctg gagcacaccg aagggcaatc taaattgtgg cttgaaggac   2447

 tgcactaaaa cccactaaaa agatgcgaaa acctgatgag ggcaaaccag ttaaacctaa   2507

 caccctgcct tgtctgggct catcacctct ccctatccca gactaacttt actgtgaaat   2567

 cctaccacat tccatgtctg aatttttgga ttcggggtgg attttcgttg tccgtggaag   2627

 aacacatgga tctctctggc tttctcaccc aagttggcca cttacgctaa tcctggaagt   2687

 atgatcactt ttgaacctgc cccttaacct tgacgaggat acaaaagtga aagcatcatc   2747

 ccccaaagga tcactgcaca gtcctactac agtattttta agtagccctc taaatactta   2807

 attttaagca aaatcccttg gccgcacttt taaggttttt ttatatgtgt atagttacca   2867

 acctaaaaat aaaaaatccg aacagcatac ttgaagaatg taatactcaa actctcagtg   2927

 cttccttatg gtttctaata ggatttttta ttattgttat tattattatt gggttttttt   2987

 ggacagggtt gggagggtct tttatttttc ctttgaaata aagaagtgat gtttttaaat   3047

 gaaaaaatgt gtggatattt aagtgtgctg ctccctcttg tcttgaaaca gtttgagtaa   3107

 gaaagtcttg ctgtaaatgc tgccctctgc cgcctttgtt ttgagatgca gtttaaactc   3167

 cctctggctg ctgctgctgc tttttggtgt cccgacatac ctacgccccc gttttatggg   3227

 tttggcttag ttgaagagga aagggttgtg caaggagagc aggaggctgt ttccaaaaac   3287

 cagtgtagta ggatagggat tttttttttt ttttttgccc caagaaaacg ttcacccagt   3347

 gatcttgggc tggggttgtc tttaggaaaa gttgagacta taagagtcat aaataagtcc   3407

 ttgtgtttcc ttaatttatt ttgttaacac ccctaattac aaccaaagtg atgatgtgga   3467

 gtcttctgtc ttcattttgg ccccagcatt cttaatttca aagctttatt ctgtctgcct   3527

 aagagaatca accaaaggtg attctcctaa agagcagtga aggaaatgtc aggttagcag   3587

 gacccaagtt ttgggtgtga aatgttgcca gcttcctata atgtaaacgg acttgttaac   3647

 ctaacctaat tatgctcagt ggacttctat agatggtttt gaaaaatgaa ctgagctgcc   3707

 ttcccgcatc gcataaccag ttccatcatc ctggtggaac ttgaacattt agagtttatc   3767

 tagagagctt ggttaatctt tccatattat ttgtagtatt ggtcacaaat gctgttccct   3827

 cttagcctca ttctgtgcaa ccaagtgcat ataagatgcc ctgaaaagag taacaaagta   3887

 tgctttgcct gtttccactt accaggaaat tccttcagaa ctagattagc attgccctgc   3947

 ctgtctgaaa ggacagttta cctaatggtg ccagcctcct tttgctttgg caagctggat   4007

 ttctcagagc cagcatgttg tttccataac tactttgata ttttaactca ggtactccag   4067

 tcttcacccc aacctcagct gattgtagta cacctgctag ctctgttgcc ccctcaaaac   4127

 tgcacccaga gcagggccac aagggtgctt tttttcttta aaaaaaaaaa aaattagaac   4187

 caattcatgt tcatgccaaa aacaaattgt ccccaagcct atatgtatta aaatgttaac   4247

 tttgcctaaa aatattgcag tgacttttta ggcaggagtg ccaaaggaca ctatgaactt   4307

 tttgaactga cagtttctcc taactttctg ctttagcgta attgctcaga gtagagagcc   4367

 cccacaaagt tatttaaaag atgccctagc agcaatccac cagtttttct aagctagaac   4427

 ctttgagtcc cccaaactgc ctgaagactt aagttttgtg ggcactggaa gtcactttga   4487

 tagatggatt gaaactgttc ctatttgccc tgggacggtt tctatctatc aaaggaaggt   4547

 tttcacctgt agaaagcccc ctgcctccag ccaaatagtc ccatgctgac tttctatctt   4607

 cctttctcaa actgtcttag gaaggacctt cagtgcagat caggtgcagt aatggctttc   4667

 ttgtccctta attattcacc agacccagaa gttgtacgca tttaatgctg tttgtaacca   4727

 tgcatctgtt ttcattcttt gctgtacctt ttgctgccca tcctgttact tttgagtttc   4787

 tttcattgtg gttgttcttg ggttcttttg tcttgtcaga gctcttctat aacctcgctc   4847

 taatggctta acagttgttc tgggtggaaa cgtcccctca tttgaatgct cctctaaaaa   4907

 aaaaaaaaaa                                                          4917




      <210> 502
      <211> 2531
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(1550)

      <400> 502
 tcgggaggtt aatcggccga ggggagttgg ctcgcgctgg tgacggcgcc tgggtcccc      59                                                                 
 atg gcg ctg tgg cgc ggc tcc gcg tac gcg ggc ttc ctg gcg ctg gcc      107
 Met Ala Leu Trp Arg Gly Ser Ala Tyr Ala Gly Phe Leu Ala Leu Ala
   1               5                  10                  15

 gtg ggc tgc gtc ttc ctg ctg gag cca gag ctg cca ggc tcg gcg ctg      155
 Val Gly Cys Val Phe Leu Leu Glu Pro Glu Leu Pro Gly Ser Ala Leu
              20                  25                  30

 cgc tct ctc tgg agc tcg ctg tgt ctg ggg ccc gcg cct gcg ccc ccg      203
 Arg Ser Leu Trp Ser Ser Leu Cys Leu Gly Pro Ala Pro Ala Pro Pro
          35                  40                  45

 gga ccc gtc tcc ccc gag ggc cgg ttg gcg gca gcc tgg gac gcg ctt      251
 Gly Pro Val Ser Pro Glu Gly Arg Leu Ala Ala Ala Trp Asp Ala Leu
      50                  55                  60

 atc gtg cgg cca gtc cgg cgc tgg cgc cgc gtg gca gtg gga gtc aat      299
 Ile Val Arg Pro Val Arg Arg Trp Arg Arg Val Ala Val Gly Val Asn
  65                  70                  75                  80

 gca tgt gtt gat gtg gtg ctc tca ggg gtg aag ctc ttg cag gca ctt      347
 Ala Cys Val Asp Val Val Leu Ser Gly Val Lys Leu Leu Gln Ala Leu
                  85                  90                  95

 ggc ctt agt cct ggg aat ggg aaa gat cac agc att ctg cat tca agg      395
 Gly Leu Ser Pro Gly Asn Gly Lys Asp His Ser Ile Leu His Ser Arg
             100                 105                 110

 aat gat ctg gaa gaa gcc ttc att cac ttc atg ggg aag gga gca gct      443
 Asn Asp Leu Glu Glu Ala Phe Ile His Phe Met Gly Lys Gly Ala Ala
         115                 120                 125

 gct gag cgc ttc ttc agt gat aag gaa act ttt cac gac att gcc cag      491
 Ala Glu Arg Phe Phe Ser Asp Lys Glu Thr Phe His Asp Ile Ala Gln
     130                 135                 140

 gtt gcg tca gag ttc cca gga gcc cag cac tat gta gga gga aat gca      539
 Val Ala Ser Glu Phe Pro Gly Ala Gln His Tyr Val Gly Gly Asn Ala
 145                 150                 155                 160

 gct tta att gga cag aaa ttt gca gcc aac tca gat tta aag gtt ctt      587
 Ala Leu Ile Gly Gln Lys Phe Ala Ala Asn Ser Asp Leu Lys Val Leu
                 165                 170                 175

 ctt tgc ggt cca gtt ggt cca aag cta cat gag ctt ctt gat gac aat      635
 Leu Cys Gly Pro Val Gly Pro Lys Leu His Glu Leu Leu Asp Asp Asn
             180                 185                 190

 gtc ttt gtt cca cca gag tca ttg cag gaa gtg gat gag ttc cac ctc      683
 Val Phe Val Pro Pro Glu Ser Leu Gln Glu Val Asp Glu Phe His Leu
         195                 200                 205

 att tta gag tat caa gca ggg gag gag tgg ggc cag tta aaa gct ccc      731
 Ile Leu Glu Tyr Gln Ala Gly Glu Glu Trp Gly Gln Leu Lys Ala Pro
     210                 215                 220

 cat gcc aac cga ttc atc ttc tct cac gac ctc tcc aac ggg gcc atg      779
 His Ala Asn Arg Phe Ile Phe Ser His Asp Leu Ser Asn Gly Ala Met
 225                 230                 235                 240

 aat atg ctg gag gtg ttt gtg tct agc ctg gag gag ttt cag cca gac      827
 Asn Met Leu Glu Val Phe Val Ser Ser Leu Glu Glu Phe Gln Pro Asp
                 245                 250                 255

 ctg gtg gtc ctc tct gga ttg cac atg atg gag gga caa agc aag gag      875
 Leu Val Val Leu Ser Gly Leu His Met Met Glu Gly Gln Ser Lys Glu
             260                 265                 270

 ctc cag agg aag aga ctc ttg gag gtt gta acc tcc att tct gac atc      923
 Leu Gln Arg Lys Arg Leu Leu Glu Val Val Thr Ser Ile Ser Asp Ile
         275                 280                 285

 ccc act ggt att cca gtt cac cta gag ctg gcc agt atg act aac agg      971
 Pro Thr Gly Ile Pro Val His Leu Glu Leu Ala Ser Met Thr Asn Arg
     290                 295                 300

 gag ctc atg agc agc att gtc cat cag gtc ttt ccc gcg gtg act tcc     1019
 Glu Leu Met Ser Ser Ile Val His Gln Val Phe Pro Ala Val Thr Ser
 305                 310                 315                 320

 ctt ggg ctg aat gaa cag gag ctg tta ttt ctc acc cag tca gcc tct     1067
 Leu Gly Leu Asn Glu Gln Glu Leu Leu Phe Leu Thr Gln Ser Ala Ser
                 325                 330                 335

 gga cct cac tct tct ctc tct tcc tgg aac ggt gtt cct gat gtg ggc     1115
 Gly Pro His Ser Ser Leu Ser Ser Trp Asn Gly Val Pro Asp Val Gly
             340                 345                 350

 atg gtc agt gac atc ctc ttc tgg atc ttg aaa gaa cat ggg agg agt     1163
 Met Val Ser Asp Ile Leu Phe Trp Ile Leu Lys Glu His Gly Arg Ser
         355                 360                 365

 aaa agc aga gcc tcg gat ctc acc agg atc cat ttc cac acg ctg gtc     1211
 Lys Ser Arg Ala Ser Asp Leu Thr Arg Ile His Phe His Thr Leu Val
     370                 375                 380

 tac cac atc ctg gca act gtg gat gga cac tgg gcc aac cag ctg gca     1259
 Tyr His Ile Leu Ala Thr Val Asp Gly His Trp Ala Asn Gln Leu Ala
 385                 390                 395                 400

 gcc gtg gct gca gga gct cgt gtg gct ggg aca cag gcc tgc gcc aca     1307
 Ala Val Ala Ala Gly Ala Arg Val Ala Gly Thr Gln Ala Cys Ala Thr
                 405                 410                 415

 gaa acc ata gac acc agc cga gtg tct ctg agg gca ccc caa gag ttc     1355
 Glu Thr Ile Asp Thr Ser Arg Val Ser Leu Arg Ala Pro Gln Glu Phe
             420                 425                 430

 atg act tcc cat tcg gag gca ggc tcc agg att gta tta aac cca aac     1403
 Met Thr Ser His Ser Glu Ala Gly Ser Arg Ile Val Leu Asn Pro Asn
         435                 440                 445

 aag cca gta gta gaa tgg cac aga gag gga ata tcc ttc cac ttc aca     1451
 Lys Pro Val Val Glu Trp His Arg Glu Gly Ile Ser Phe His Phe Thr
     450                 455                 460

 cca gta ttg gtg tgt aaa gac ccc att cga act gta ggc ctt gga gat     1499
 Pro Val Leu Val Cys Lys Asp Pro Ile Arg Thr Val Gly Leu Gly Asp
 465                 470                 475                 480

 gcc att tca gcc gaa gga ctc ttc tat tcg gaa gta cac cct cac tat     1547
 Ala Ile Ser Ala Glu Gly Leu Phe Tyr Ser Glu Val His Pro His Tyr
                 485                 490                 495

 tag gaag attcttaggg gtaatttttc tgaggaagga gaactagcca acttaagaat     1604
 


 tacaggaaga aagtggtttg gaagacagcc aaagaaataa aagcagatta aattgtatca   1664

 ggtacattcc agcctgttgg caactccata aaaacatttc agattttaat ccgaatttag   1724

 ctaatgagac tggatttttg ttttttatgt tgtgtgtcac agagctaaaa actcagttcc   1784

 caaatcccca gtttatgcag cgccatcagg tattttaagc taaacttctt cacccctgag   1844

 agcatgtcag ctggagaaaa gcagttcttc cttgcccact tgagaagtgc acgcccactc   1904

 acccaacatc ctggtctcta ggaaagcctc atgtgaggtt cctctttctt tcagctcagt   1964

 gcccatgggc aaggatcatg atttccattc cgtgttacaa tgacaatatt taatgagcat   2024

 aaccttctca gtctcctgct ctcaaattta ggacagagcc gctaaggaca aaacaatccc   2084

 tcccgtgctt tatgatggca gcaggggctg gggagcctct gagggactct ttcattctgc   2144

 agttgtctgg aagcctgggt ggcgtcatga gctgaaggat catgctttcc tgtcctggct   2204

 ccataggtta taggctggct ggtgaaaggt tcacgtggcc caggctgaac ttcattgcct   2264

 agctttggat gtgctttctg ccataaagac tgatttttgt tcgttctgag ccttcaagga   2324

 atttgttttt tacaactgga atatgctcct gtgtgtgtta acagatcatg gatgttttat   2384

 gttttcactg atcatttaaa gagtttgacc tcagagctcc aggatcatca gtaaatttgt   2444

 catgttatat atttattttt ttataaatca agacttctgt gtgctcttaa atatattaaa   2504

 aacaatttac atttcaaaaa aaaaaaa                                       2531




      <210> 503
      <211> 1240
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (263)..(847)

      <400> 503
 taattcctga tattgctatt gtaaggataa caggagctag acttttgaag ttactcatga     60

 cattagtttg ttgataggaa attctttttt tgaagagcag gaaaatctgt tacatgccat    120

 tatgctctta aagtgtagca ataaggttaa actttttgtg ttctgcagct atggttttgt    180

 ttccttttaa ctatccactg taaaagcctt tttattttaa aatccacact ttttgctgaa    240

 tttagcttgt tagtaattga tt atg caa gaa atg aat gac aaa gca att ttt     292
                          Met Gln Glu Met Asn Asp Lys Ala Ile Phe
                            1               5                  10

 aaa aca ttg ttt ttg ttt ttt cct cag tcc ttg gtt ttg atc agc aaa      340
 Lys Thr Leu Phe Leu Phe Phe Pro Gln Ser Leu Val Leu Ile Ser Lys
                  15                  20                  25

 cta cct tat att cat ttt ttt cac act gtg ctc aaa cag ata gca cca      388
 Leu Pro Tyr Ile His Phe Phe His Thr Val Leu Lys Gln Ile Ala Pro
              30                  35                  40

 gag tat ttt gaa aag aat gaa cct tat ttg gaa gca gct tgt aat gat      436
 Glu Tyr Phe Glu Lys Asn Glu Pro Tyr Leu Glu Ala Ala Cys Asn Asp
          45                  50                  55

 gtt gat cga tgg cct gcc cca gtg cca ggg aaa aca tta cac ctg cca      484
 Val Asp Arg Trp Pro Ala Pro Val Pro Gly Lys Thr Leu His Leu Pro
      60                  65                  70

 atc atg ggg gtg gta atg aag gta cgg att ccc aca tgt cat gac aag      532
 Ile Met Gly Val Val Met Lys Val Arg Ile Pro Thr Cys His Asp Lys
  75                  80                  85                  90

 cct ggg aca act caa ata gtg cag tta act cag cag gtg gac aca aat      580
 Pro Gly Thr Thr Gln Ile Val Gln Leu Thr Gln Gln Val Asp Thr Asn
                  95                 100                 105

 ata tct gtt att tta cct act gtt cat gag ggg gat att ttc agg tgt      628
 Ile Ser Val Ile Leu Pro Thr Val His Glu Gly Asp Ile Phe Arg Cys
             110                 115                 120

 ttc tgc cca gtt ttc ctt cat agt cag atg ctc tgg gag ctg gtg ctg      676
 Phe Cys Pro Val Phe Leu His Ser Gln Met Leu Trp Glu Leu Val Leu
         125                 130                 135

 ttg ggg gag ccc ctt gtg gtt atg gcg cca tca cca tcg gaa tca tca      724
 Leu Gly Glu Pro Leu Val Val Met Ala Pro Ser Pro Ser Glu Ser Ser
     140                 145                 150

 gag act gta ttg gca ctt gtt aac tgt att tct cca tta aag tac ttc      772
 Glu Thr Val Leu Ala Leu Val Asn Cys Ile Ser Pro Leu Lys Tyr Phe
 155                 160                 165                 170

 agt gat ttc cga cct tat ttc act att cat gat agt gaa ttc aaa gaa      820
 Ser Asp Phe Arg Pro Tyr Phe Thr Ile His Asp Ser Glu Phe Lys Glu
                 175                 180                 185

 tat act acc cgt acc caa gct ccg taa gtaaa aataacttct attgaccagg      872
 Tyr Thr Thr Arg Thr Gln Ala Pro 
             190

 tattaccttt ataaccaaaa ttgtgtagaa ttatttttgg taataaaagc ttataggcag    932

 aatgatctta taaaaggaaa gtttgaggag ctgctggaaa taattttaga ttttaagagt    992

 tagtacctta tttgagcgat tttatgtatt tatttttatt tatttatttt tgagacagag   1052

 gtttgctctg tcgcccaggc tggagtgcag tggcatgatc tcggcttaat gcaacctttt   1112

 gcctctgggg tcaagacact ctcctgcctt aatgctattg tcgagcctgg gaattccggg   1172

 cttggggcca ccccggcccg gtcgtaagtt ttggagattt tcacacgggc cccggggcct   1232

 cccgaaag                                                            1240




      <210> 504
      <211> 4398
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (280)..(2958)

      <400> 504
 gaggccgccg cctgggtcgc tcaacttccg ggtcaaaggt gcctgagccg gcgggtcccc     60

 tgtgtccgcc gcggctgtcg tcccccgctc ccgccacttc cggggtcgca gtcccgggca    120

 tggagccgcg accgtgaggc gccgctggac ccgggacgac ctgcccagtc cggccgccgc    180

 cccacgtccc ggtctgtgtc ccacgcctgc agctggaatg gaggctctct ggacccttta    240

 gaaggcaccc ctgccctcct gaggtcagct gagcggtta   atg cgg aag gtt aag     294
                                              Met Arg Lys Val Lys
                                                1               5

 aaa ctg cgc ctg gac aag gag aac acc gga agt tgg aga agc ttc tcg      342
 Lys Leu Arg Leu Asp Lys Glu Asn Thr Gly Ser Trp Arg Ser Phe Ser
                  10                  15                  20

 ctg aat tcc gag ggg gct gag agg atg gcc acc acc ggg acc cca acg      390
 Leu Asn Ser Glu Gly Ala Glu Arg Met Ala Thr Thr Gly Thr Pro Thr
              25                  30                  35

 gcc gac cga ggc gac gca gcc gcc aca gat gac ccg gcc gcc cgc ttc      438
 Ala Asp Arg Gly Asp Ala Ala Ala Thr Asp Asp Pro Ala Ala Arg Phe
          40                  45                  50

 cag gtg cag aag cac tcg tgg gac ggg ctc cgg agc atc atc cac ggc      486
 Gln Val Gln Lys His Ser Trp Asp Gly Leu Arg Ser Ile Ile His Gly
      55                  60                  65

 agc cgc aag tac tcg ggc ctc att gtc aac aag gcg ccc cac gac ttc      534
 Ser Arg Lys Tyr Ser Gly Leu Ile Val Asn Lys Ala Pro His Asp Phe
  70                  75                  80                  85

 cag ttt gtg cag aag acg gat gag tct ggg ccc cac tcc cac cgc ctc      582
 Gln Phe Val Gln Lys Thr Asp Glu Ser Gly Pro His Ser His Arg Leu
                  90                  95                 100

 tac tac ctg gga atg cca tat ggc agc cga gag aac tcc ctc ctc tac      630
 Tyr Tyr Leu Gly Met Pro Tyr Gly Ser Arg Glu Asn Ser Leu Leu Tyr
             105                 110                 115

 tct gag att ccc aag aag gtc cgg aaa gag gct ctg ctg ctc ctg tcc      678
 Ser Glu Ile Pro Lys Lys Val Arg Lys Glu Ala Leu Leu Leu Leu Ser
         120                 125                 130

 tgg aag cag atg ctg gat cat ttc cag gcc acg ccc cac cat ggg gtc      726
 Trp Lys Gln Met Leu Asp His Phe Gln Ala Thr Pro His His Gly Val
     135                 140                 145

 tac tct cgg gag gag gag ctg ctg agg gag cgg aaa cgc ctg ggg gtc      774
 Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg Leu Gly Val
 150                 155                 160                 165

 ttc ggc atc acc tcc tac gac ttc cac agc gag agt ggc ctc ttc ctc      822
 Phe Gly Ile Thr Ser Tyr Asp Phe His Ser Glu Ser Gly Leu Phe Leu
                 170                 175                 180

 ttc cag gcc agc aac agc ctc ttc cac tgc cgc gac ggc ggc aag aac      870
 Phe Gln Ala Ser Asn Ser Leu Phe His Cys Arg Asp Gly Gly Lys Asn
             185                 190                 195

 ggc ttc atg gtg tcc cct atg aaa ccg ctg gaa atc aag acc cag tgc      918
 Gly Phe Met Val Ser Pro Met Lys Pro Leu Glu Ile Lys Thr Gln Cys
         200                 205                 210

 tca ggg ccc cgg atg gac ccc aaa atc tgc cct gcc gac cct gcc ttc      966
 Ser Gly Pro Arg Met Asp Pro Lys Ile Cys Pro Ala Asp Pro Ala Phe
     215                 220                 225

 ttc tcc ttc atc aat aac agc gac ctg tgg gtg gcc aac atc gag aca     1014
 Phe Ser Phe Ile Asn Asn Ser Asp Leu Trp Val Ala Asn Ile Glu Thr
 230                 235                 240                 245

 ggc gag gag cgg cgg ctg acc ttc tgc cac caa ggt tta tcc aat gtc     1062
 Gly Glu Glu Arg Arg Leu Thr Phe Cys His Gln Gly Leu Ser Asn Val
                 250                 255                 260

 ctg gat gac ccc aag tct gcg ggt gtg gcc acc ttc gtc ata cag gaa     1110
 Leu Asp Asp Pro Lys Ser Ala Gly Val Ala Thr Phe Val Ile Gln Glu
             265                 270                 275

 gag ttc gac cgc ttc act ggg tac tgg tgg tgc ccc aca gcc tcc tgg     1158
 Glu Phe Asp Arg Phe Thr Gly Tyr Trp Trp Cys Pro Thr Ala Ser Trp
         280                 285                 290

 gaa ggt tca gag ggc ctc aag acg ctg cga atc ctg tat gag gaa gtc     1206
 Glu Gly Ser Glu Gly Leu Lys Thr Leu Arg Ile Leu Tyr Glu Glu Val
     295                 300                 305

 gat gag tcc gag gtg gag gtc att cac gtc ccc tct cct gcg cta gaa     1254
 Asp Glu Ser Glu Val Glu Val Ile His Val Pro Ser Pro Ala Leu Glu
 310                 315                 320                 325

 gaa agg aag acg gac tcg tat cgg tac ccc agg aca ggc agc aag aat     1302
 Glu Arg Lys Thr Asp Ser Tyr Arg Tyr Pro Arg Thr Gly Ser Lys Asn
                 330                 335                 340

 ccc aag att gcc ttg aaa ctg gct gag ttc cag act gac agc cag ggc     1350
 Pro Lys Ile Ala Leu Lys Leu Ala Glu Phe Gln Thr Asp Ser Gln Gly
             345                 350                 355

 aag atc gtc tcg acc cag gag aag gag ctg gtg cag ccc ttc agc tcg     1398
 Lys Ile Val Ser Thr Gln Glu Lys Glu Leu Val Gln Pro Phe Ser Ser
         360                 365                 370

 ctg ttc ccg aag gtg gag tac atc gcc agg gcc ggg tgg acc cgg gat     1446
 Leu Phe Pro Lys Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr Arg Asp
     375                 380                 385

 ggc aaa tac gcc tgg gcc atg ttc ctg gac cgg ccc cag cag tgg ctc     1494
 Gly Lys Tyr Ala Trp Ala Met Phe Leu Asp Arg Pro Gln Gln Trp Leu
 390                 395                 400                 405

 cag ctc gtc ctc ctc ccc ccg gcc ctg ttc atc ccg agc aca gag aat     1542
 Gln Leu Val Leu Leu Pro Pro Ala Leu Phe Ile Pro Ser Thr Glu Asn
                 410                 415                 420

 gag gag cag cgg cta gcc tct gcc aga gct gtc ccc agg aat gtc cag     1590
 Glu Glu Gln Arg Leu Ala Ser Ala Arg Ala Val Pro Arg Asn Val Gln
             425                 430                 435

 ccg tat gtg gtg tac gag gag gtc acc aac gtc tgg atc aat gtt cat     1638
 Pro Tyr Val Val Tyr Glu Glu Val Thr Asn Val Trp Ile Asn Val His
         440                 445                 450

 gac atc ttc tat ccc ttc ccc caa tca gag gga gag gac gag ctc tgc     1686
 Asp Ile Phe Tyr Pro Phe Pro Gln Ser Glu Gly Glu Asp Glu Leu Cys
     455                 460                 465

 ttt ctc cgc gcc aat gaa tgc aag acc ggc ttc tgc cat ttg tac aaa     1734
 Phe Leu Arg Ala Asn Glu Cys Lys Thr Gly Phe Cys His Leu Tyr Lys
 470                 475                 480                 485

 gtc acc gcc gtt tta aaa tcc cag ggc tac gat tgg agt gag ccc ttc     1782
 Val Thr Ala Val Leu Lys Ser Gln Gly Tyr Asp Trp Ser Glu Pro Phe
                 490                 495                 500

 agc ccc ggg gaa gat gaa ttt aag tgc ccc att aag gaa gag att gct     1830
 Ser Pro Gly Glu Asp Glu Phe Lys Cys Pro Ile Lys Glu Glu Ile Ala
             505                 510                 515

 ctg acc agc ggt gaa tgg gag gtt ttg gcg agg cac ggc tcc aag atc     1878
 Leu Thr Ser Gly Glu Trp Glu Val Leu Ala Arg His Gly Ser Lys Ile
         520                 525                 530

 tgg gtc aat gag gag acc aag ctg gtg tac ttc cag ggc acc aag gac     1926
 Trp Val Asn Glu Glu Thr Lys Leu Val Tyr Phe Gln Gly Thr Lys Asp
     535                 540                 545

 acg ccg ctg gag cac cac ctc tac gtg gtc agc tat gag gcg gcc ggc     1974
 Thr Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Glu Ala Ala Gly
 550                 555                 560                 565

 gag atc gta cgc ctc acc acg ccc ggc ttc tcc cat agc tgc tcc atg     2022
 Glu Ile Val Arg Leu Thr Thr Pro Gly Phe Ser His Ser Cys Ser Met
                 570                 575                 580

 agc cag aac ttc gac atg ttc gtc agc cac tac agc agc gtg agc acg     2070
 Ser Gln Asn Phe Asp Met Phe Val Ser His Tyr Ser Ser Val Ser Thr
             585                 590                 595

 ccg ccc tgc gtg cac gtc tac aag ctg agc ggc ccc gac gac gac ccc     2118
 Pro Pro Cys Val His Val Tyr Lys Leu Ser Gly Pro Asp Asp Asp Pro
         600                 605                 610

 ctg cac aag cag ccc cgc ttc tgg gct agc atg atg gag gca gcc agc     2166
 Leu His Lys Gln Pro Arg Phe Trp Ala Ser Met Met Glu Ala Ala Ser
     615                 620                 625

 tgc ccc ccg gat tat gtt cct cca gag atc ttc cat ttc cac acg cgc     2214
 Cys Pro Pro Asp Tyr Val Pro Pro Glu Ile Phe His Phe His Thr Arg
 630                 635                 640                 645

 tcg gat gtg cgg ctc tac ggc atg atc tac aag ccc cac gcc ttg cag     2262
 Ser Asp Val Arg Leu Tyr Gly Met Ile Tyr Lys Pro His Ala Leu Gln
                 650                 655                 660

 cca ggg aag aag cac ccc acc gtc ctc ttt gta tat gga ggc ccc cag     2310
 Pro Gly Lys Lys His Pro Thr Val Leu Phe Val Tyr Gly Gly Pro Gln
             665                 670                 675

 gtg cag ctg gtg aat aac tcc ttc aaa ggc atc aag tac ttg cgg ctc     2358
 Val Gln Leu Val Asn Asn Ser Phe Lys Gly Ile Lys Tyr Leu Arg Leu
         680                 685                 690

 aac aca ctg gcc tcc ctg ggc tac gcc gtg gtt gtg att gac ggc agg     2406
 Asn Thr Leu Ala Ser Leu Gly Tyr Ala Val Val Val Ile Asp Gly Arg
     695                 700                 705

 ggc tcc tgt cag cga ggg ctt cgg ttc gaa ggg gcc ctg aaa aac caa     2454
 Gly Ser Cys Gln Arg Gly Leu Arg Phe Glu Gly Ala Leu Lys Asn Gln
 710                 715                 720                 725

 atg ggc cag gtg gag atc gag gac cag gtg gag ggc ctg cag ttc gtg     2502
 Met Gly Gln Val Glu Ile Glu Asp Gln Val Glu Gly Leu Gln Phe Val
                 730                 735                 740

 gcc gag aag tat ggc ttc atc gac ctg agc cga gtt gcc atc cat ggc     2550
 Ala Glu Lys Tyr Gly Phe Ile Asp Leu Ser Arg Val Ala Ile His Gly
             745                 750                 755

 tgg tcc tac ggg ggc ttc ctc tcg ctc atg ggg cta atc cac aag ccc     2598
 Trp Ser Tyr Gly Gly Phe Leu Ser Leu Met Gly Leu Ile His Lys Pro
         760                 765                 770

 cag gtg ttc aag gtg gcc atc gcg ggt gcc ccg gtc acc gtc tgg atg     2646
 Gln Val Phe Lys Val Ala Ile Ala Gly Ala Pro Val Thr Val Trp Met
     775                 780                 785

 gcc tac gac aca ggg tac act gag cgc tac atg gac gtc cct gag aac     2694
 Ala Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met Asp Val Pro Glu Asn
 790                 795                 800                 805

 aac cag cac ggc tat gag gcg ggt tcc gtg gcc ctg cac gtg gag aag     2742
 Asn Gln His Gly Tyr Glu Ala Gly Ser Val Ala Leu His Val Glu Lys
                 810                 815                 820

 ctg ccc aat gag ccc aac cgc ttg ctt atc ctc cac ggc ttc ctg gac     2790
 Leu Pro Asn Glu Pro Asn Arg Leu Leu Ile Leu His Gly Phe Leu Asp
             825                 830                 835

 gaa aac gtg cac ttt ttc cac aca aac ttc ctc gtc tcc caa ctg atc     2838
 Glu Asn Val His Phe Phe His Thr Asn Phe Leu Val Ser Gln Leu Ile
         840                 845                 850

 cga gca ggg aaa cct tac cag ctc cag atc tac ccc aac gag aga cac     2886
 Arg Ala Gly Lys Pro Tyr Gln Leu Gln Ile Tyr Pro Asn Glu Arg His
     855                 860                 865

 agt att cgc tgc ccc gag tcg ggc gag cac tat gaa gtc acg ttg ctg     2934
 Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr Glu Val Thr Leu Leu
 870                 875                 880                 885

 cac ttt cta cag gaa tac ctc tga gcctgcccac cgggagccgc cacatcacag    2988
 His Phe Leu Gln Glu Tyr Leu 
                 890

 cacaagtggc tgcagcctcc gcggggaacc aggcgggagg gactgagtgg cccgcgggcc   3048

 ccagtgaggc actttgtccc gcccagcgct ggccagcccc gaggagccgc tgccttcacc   3108

 gccccgacgc cttttatcct tttttaaacg ctcttgggtt ttatgtccgc tgcttcttgg   3168

 ttgccgagac agagagatgg tggtctcggg ccagcccctc ctctccccgc cttctgggag   3228

 gaggaggtca cacgctgatg ggcactggag aggccagaag agactcagag gagcgggctg   3288

 ccttccgcct ggggctccct gtgacctctc agtcccctgg cccggccagc caccgtcccc   3348

 agcacccaag catgcaattg cctgtccccc ccggccagcc tccccaactt gatgtttgtg   3408

 ttttgtttgg ggggatattt ttcataatta tttaaaagac aggccgggcg cggtggctca   3468

 cgtctgtaat cccagcactt tgggaggctg aggcgggcgg atcacctgag gttgggagtt   3528

 caagaccagc ctggccaaca tggggaaacc ccgtctctac taaaaataca aaaaattagc   3588

 cgggtgtggt ggcgcgtgcc tataatccca gctactcggg aggctgaggc aggagaatcg   3648

 cttgaacccg ggaggtggag gttgcggtga gccaagatcg caccattgca ctccagcctg   3708

 ggcaacaaga gcgaaactct gtctcaaaat aaataaaaaa taaaagacag aaagcaaggg   3768

 gtgcctaaat ctagacttgg ggtccacacc gggcagcggg gttgcaaccc agcacctggt   3828

 aggctccatt tcttcccaag cccgagcaga gggtcatgcg ggccccacag gagaagcggc   3888

 cagggcccgc ggggggcacc acctgtggac agccctcctg tccccaagct ttcaggcagg   3948

 cactgaaacg caccgaactt ccacgctctg ctggtcagtg gcggctgtcc cctccccagc   4008

 ccagccgccc agccacatgt gtctgcctga cccgtacaca ccaggggttc cggggttggg   4068

 agctgaacca tccccacctc agggttatat ttccctctcc ccttccctcc ccgccaagag   4128

 ctctgccagg ggcgggcaaa aaaaaaagta aaaagaaaag aaaaaaaaaa aaaaaaaaaa   4188

 caaaccacct ctacatatta tggaaagaaa atatttttgt cgattcttat tcttttataa   4248

 ttatgcgtgg aagaagtaga cacattaaac gattccagtt ggaaacatga aaaaaaaaaa   4308

 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaacaaaaa aaaaaaaaaa   4368

 aaaaaaaaaa ataaaaaaaa aaaaaaaaaa                                    4398




      <210> 505
      <211> 4284
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (280)..(2844)

      <400> 505
 gaggccgccg cctgggtcgc tcaacttccg ggtcaaaggt gcctgagccg gcgggtcccc     60

 tgtgtccgcc gcggctgtcg tcccccgctc ccgccacttc cggggtcgca gtcccgggca    120

 tggagccgcg accgtgaggc gccgctggac ccgggacgac ctgcccagtc cggccgccgc    180

 cccacgtccc ggtctgtgtc ccacgcctgc agctggaatg gaggctctct ggacccttta    240

 gaaggcaccc ctgccctcct gaggtcagct gagcggtta   atg cgg aag gtt aag     294
                                              Met Arg Lys Val Lys
                                                1               5

 aaa ctg cgc ctg gac aag gag aac acc gga agt tgg aga agc ttc tcg      342
 Lys Leu Arg Leu Asp Lys Glu Asn Thr Gly Ser Trp Arg Ser Phe Ser
                  10                  15                  20

 ctg aat tcc gag ggg gct gag agg atg gcc acc acc ggg acc cca acg      390
 Leu Asn Ser Glu Gly Ala Glu Arg Met Ala Thr Thr Gly Thr Pro Thr
              25                  30                  35

 gcc gac cga ggc gac gca gcc gcc aca gat gac ccg gcc gcc cgc ttc      438
 Ala Asp Arg Gly Asp Ala Ala Ala Thr Asp Asp Pro Ala Ala Arg Phe
          40                  45                  50

 cag gtg cag aag cac tcg tgg gac ggg ctc cgg agc atc atc cac ggc      486
 Gln Val Gln Lys His Ser Trp Asp Gly Leu Arg Ser Ile Ile His Gly
      55                  60                  65

 agc cgc aag tac tcg ggc ctc att gtc aac aag gcg ccc cac gac ttc      534
 Ser Arg Lys Tyr Ser Gly Leu Ile Val Asn Lys Ala Pro His Asp Phe
  70                  75                  80                  85

 cag ttt gtg cag aag acg gat gag tct ggg ccc cac tcc cac cgc ctc      582
 Gln Phe Val Gln Lys Thr Asp Glu Ser Gly Pro His Ser His Arg Leu
                  90                  95                 100

 tac tac ctg gga atg cca tat ggc agc cga gag aac tcc ctc ctc tac      630
 Tyr Tyr Leu Gly Met Pro Tyr Gly Ser Arg Glu Asn Ser Leu Leu Tyr
             105                 110                 115

 tct gag att ccc aag aag gtc cgg aaa gag gct ctg ctg ctc ctg tcc      678
 Ser Glu Ile Pro Lys Lys Val Arg Lys Glu Ala Leu Leu Leu Leu Ser
         120                 125                 130

 tgg aag cag atg ctg gat cat ttc cag gcc acg ccc cac cat ggg gtc      726
 Trp Lys Gln Met Leu Asp His Phe Gln Ala Thr Pro His His Gly Val
     135                 140                 145

 tac tct cgg gag gag gag ctg ctg agg gag cgg aaa cgc ctg ggg gtc      774
 Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg Leu Gly Val
 150                 155                 160                 165

 ttc ggc atc acc tcc tac gac ttc cac agc gag agt ggc ctc ttc ctc      822
 Phe Gly Ile Thr Ser Tyr Asp Phe His Ser Glu Ser Gly Leu Phe Leu
                 170                 175                 180

 ttc cag gcc agc aac agc ctc ttc cac tgc cgc gac ggc ggc aag aac      870
 Phe Gln Ala Ser Asn Ser Leu Phe His Cys Arg Asp Gly Gly Lys Asn
             185                 190                 195

 ggc ttc atg gtg tcc cct atg aaa ccg ctg gaa atc aag acc cag tgc      918
 Gly Phe Met Val Ser Pro Met Lys Pro Leu Glu Ile Lys Thr Gln Cys
         200                 205                 210

 tca ggg ccc cgg atg gac ccc aaa atc tgc cct gcc gac cct gcc ttc      966
 Ser Gly Pro Arg Met Asp Pro Lys Ile Cys Pro Ala Asp Pro Ala Phe
     215                 220                 225

 ttc tcc ttc atc aat aac agc gac ctg tgg gtg gcc aac atc gag aca     1014
 Phe Ser Phe Ile Asn Asn Ser Asp Leu Trp Val Ala Asn Ile Glu Thr
 230                 235                 240                 245

 ggc gag gag cgg cgg ctg acc ttc tgc cac caa ggt tta tcc aat gtc     1062
 Gly Glu Glu Arg Arg Leu Thr Phe Cys His Gln Gly Leu Ser Asn Val
                 250                 255                 260

 ctg gat gac ccc aag tct gcg ggt gtg gcc acc ttc gtc ata cag gaa     1110
 Leu Asp Asp Pro Lys Ser Ala Gly Val Ala Thr Phe Val Ile Gln Glu
             265                 270                 275

 gag ttc gac cgc ttc act ggg tac tgg tgg tgc ccc aca gcc tcc tgg     1158
 Glu Phe Asp Arg Phe Thr Gly Tyr Trp Trp Cys Pro Thr Ala Ser Trp
         280                 285                 290

 gaa ggt tca gag ggc ctc aag acg ctg cga atc ctg tat gag gaa gtc     1206
 Glu Gly Ser Glu Gly Leu Lys Thr Leu Arg Ile Leu Tyr Glu Glu Val
     295                 300                 305

 gat gag tcc gag gtg gag gtc att cac gtc ccc tct cct gcg cta gaa     1254
 Asp Glu Ser Glu Val Glu Val Ile His Val Pro Ser Pro Ala Leu Glu
 310                 315                 320                 325

 gaa agg aag acg gac tcg tat cgg tac ccc agg aca ggc agc aag aat     1302
 Glu Arg Lys Thr Asp Ser Tyr Arg Tyr Pro Arg Thr Gly Ser Lys Asn
                 330                 335                 340

 ccc aag att gcc ttg aaa ctg gct gag ttc cag act gac agc cag ggc     1350
 Pro Lys Ile Ala Leu Lys Leu Ala Glu Phe Gln Thr Asp Ser Gln Gly
             345                 350                 355

 aag atc gtc tcg acc cag gag aag gag ctg gtg cag ccc ttc agc tcg     1398
 Lys Ile Val Ser Thr Gln Glu Lys Glu Leu Val Gln Pro Phe Ser Ser
         360                 365                 370

 ctg ttc ccg aag gtg gag tac atc gcc agg gcc ggg tgg acc cgg gat     1446
 Leu Phe Pro Lys Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr Arg Asp
     375                 380                 385

 ggc aaa tac gcc tgg gcc atg ttc ctg gac cgg ccc cag cag tgg ctc     1494
 Gly Lys Tyr Ala Trp Ala Met Phe Leu Asp Arg Pro Gln Gln Trp Leu
 390                 395                 400                 405

 cag ctc gtc ctc ctc ccc ccg gcc ctg ttc atc ccg agc aca gag aat     1542
 Gln Leu Val Leu Leu Pro Pro Ala Leu Phe Ile Pro Ser Thr Glu Asn
                 410                 415                 420

 gag gag cag cgg cta gcc tct gcc aga gct gtc ccc agg aat gtc cag     1590
 Glu Glu Gln Arg Leu Ala Ser Ala Arg Ala Val Pro Arg Asn Val Gln
             425                 430                 435

 ccg tat gtg gtg tac gag gag gtc acc aac gtc tgg atc aat gtt cat     1638
 Pro Tyr Val Val Tyr Glu Glu Val Thr Asn Val Trp Ile Asn Val His
         440                 445                 450

 gac atc ttc tat ccc ttc ccc caa tca gag gga gag gac gag ctc tgc     1686
 Asp Ile Phe Tyr Pro Phe Pro Gln Ser Glu Gly Glu Asp Glu Leu Cys
     455                 460                 465

 ttt ctc cgc gcc aat gaa tgc aag acc ggc ttc tgc cat ttg tac aaa     1734
 Phe Leu Arg Ala Asn Glu Cys Lys Thr Gly Phe Cys His Leu Tyr Lys
 470                 475                 480                 485

 gtc acc gcc gtt tta aaa tcc cag ggc tac gat tgg agt gag ccc ttc     1782
 Val Thr Ala Val Leu Lys Ser Gln Gly Tyr Asp Trp Ser Glu Pro Phe
                 490                 495                 500

 agc ccc ggg gaa gat gaa ttt aag tgc ccc att aag gaa gag att gct     1830
 Ser Pro Gly Glu Asp Glu Phe Lys Cys Pro Ile Lys Glu Glu Ile Ala
             505                 510                 515

 ctg acc agc ggt gaa tgg gag gtt ttg gcg agg cac ggc tcc aag atc     1878
 Leu Thr Ser Gly Glu Trp Glu Val Leu Ala Arg His Gly Ser Lys Ile
         520                 525                 530

 tgg gtc aat gag gag acc aag ctg gtg tac ttc cag ggc acc aag gac     1926
 Trp Val Asn Glu Glu Thr Lys Leu Val Tyr Phe Gln Gly Thr Lys Asp
     535                 540                 545

 acg ccg ctg gag cac cac ctc tac gtg gtc agc tat gag gcg gcc ggc     1974
 Thr Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Glu Ala Ala Gly
 550                 555                 560                 565

 gag atc gta cgc ctc acc acg ccc ggc ttc tcc cat agc tgc tcc atg     2022
 Glu Ile Val Arg Leu Thr Thr Pro Gly Phe Ser His Ser Cys Ser Met
                 570                 575                 580

 agc cag aac ttc gac atg ttc gtc agc cac tac agc agc gtg agc acg     2070
 Ser Gln Asn Phe Asp Met Phe Val Ser His Tyr Ser Ser Val Ser Thr
             585                 590                 595

 ccg ccc tgc gtg cac gtc tac aag ctg agc ggc ccc gac gac gac ccc     2118
 Pro Pro Cys Val His Val Tyr Lys Leu Ser Gly Pro Asp Asp Asp Pro
         600                 605                 610

 ctg cac aag cag ccc cgc ttc tgg gct agc atg atg gag gca gcc agc     2166
 Leu His Lys Gln Pro Arg Phe Trp Ala Ser Met Met Glu Ala Ala Ser
     615                 620                 625

 tgc ccc ccg gat tat gtt cct cca gag atc ttc cat ttc cac acg cgc     2214
 Cys Pro Pro Asp Tyr Val Pro Pro Glu Ile Phe His Phe His Thr Arg
 630                 635                 640                 645

 tcg gat gtg cgg ctc tac ggc atg atc tac aag ccc cac gcc ttg cag     2262
 Ser Asp Val Arg Leu Tyr Gly Met Ile Tyr Lys Pro His Ala Leu Gln
                 650                 655                 660

 cca ggg aag aag cac ccc acc gtc ctc ttt gta tat gga ggc ccc cag     2310
 Pro Gly Lys Lys His Pro Thr Val Leu Phe Val Tyr Gly Gly Pro Gln
             665                 670                 675

 gtg cag ctg gtg aat aac tcc ttc aaa ggc atc aag tac ttg cgg ctc     2358
 Val Gln Leu Val Asn Asn Ser Phe Lys Gly Ile Lys Tyr Leu Arg Leu
         680                 685                 690

 aac aca ctg gcc tcc ctg ggc tac gcc gtg gtt gtg att gac ggc agg     2406
 Asn Thr Leu Ala Ser Leu Gly Tyr Ala Val Val Val Ile Asp Gly Arg
     695                 700                 705

 ggc tcc tgt cag cga ggg ctt cgg ttc gaa ggg gcc ctg aaa aac caa     2454
 Gly Ser Cys Gln Arg Gly Leu Arg Phe Glu Gly Ala Leu Lys Asn Gln
 710                 715                 720                 725

 atg ggc cag gtg gag atc gag gac cag gtg gag ggc ctg cag ttc gtg     2502
 Met Gly Gln Val Glu Ile Glu Asp Gln Val Glu Gly Leu Gln Phe Val
                 730                 735                 740

 gcc gag aag tat ggc ttc atc gac ctg agc cga gtt gcc atc cat ggc     2550
 Ala Glu Lys Tyr Gly Phe Ile Asp Leu Ser Arg Val Ala Ile His Gly
             745                 750                 755

 tgg tcc tac ggg ggc ttc ctc tcg ctc atg ggg cta atc cac aag ccc     2598
 Trp Ser Tyr Gly Gly Phe Leu Ser Leu Met Gly Leu Ile His Lys Pro
         760                 765                 770

 cag gtg ttc aag gtg gcc atc gcg ggt gcc ccg gtc acc gtc ccc aac     2646
 Gln Val Phe Lys Val Ala Ile Ala Gly Ala Pro Val Thr Val Pro Asn
     775                 780                 785

 cgc ttg ctt atc ctc cac ggc ttc ctg gac gaa aac gtg cac ttt ttc     2694
 Arg Leu Leu Ile Leu His Gly Phe Leu Asp Glu Asn Val His Phe Phe
 790                 795                 800                 805

 cac aca aac ttc ctc gtc tcc caa ctg atc cga gca ggg aaa cct tac     2742
 His Thr Asn Phe Leu Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr
                 810                 815                 820

 cag ctc cag atc tac ccc aac gag aga cac agt att cgc tgc ccc gag     2790
 Gln Leu Gln Ile Tyr Pro Asn Glu Arg His Ser Ile Arg Cys Pro Glu
             825                 830                 835

 tcg ggc gag cac tat gaa gtc acg ttg ctg cac ttt cta cag gaa tac     2838
 Ser Gly Glu His Tyr Glu Val Thr Leu Leu His Phe Leu Gln Glu Tyr
         840                 845                 850

 ctc tga gcctgcccac cgggagccgc cacatcacag cacaagtggc tgcagcctcc      2894
 Leu 


 gcggggaacc aggcgggagg gactgagtgg cccgcgggcc ccagtgaggc actttgtccc   2954

 gcccagcgct ggccagcccc gaggagccgc tgccttcacc gccccgacgc cttttatcct   3014

 tttttaaacg ctcttgggtt ttatgtccgc tgcttcttgg ttgccgagac agagagatgg   3074

 tggtctcggg ccagcccctc ctctccccgc cttctgggag gaggaggtca cacgctgatg   3134

 ggcactggag aggccagaag agactcagag gagcgggctg ccttccgcct ggggctccct   3194

 gtgacctctc agtcccctgg cccggccagc caccgtcccc agcacccaag catgcaattg   3254

 cctgtccccc ccggccagcc tccccaactt gatgtttgtg ttttgtttgg ggggatattt   3314

 ttcataatta tttaaaagac aggccgggcg cggtggctca cgtctgtaat cccagcactt   3374

 tgggaggctg aggcgggcgg atcacctgag gttgggagtt caagaccagc ctggccaaca   3434

 tggggaaacc ccgtctctac taaaaataca aaaaattagc cgggtgtggt ggcgcgtgcc   3494

 tataatccca gctactcggg aggctgaggc aggagaatcg cttgaacccg ggaggtggag   3554

 gttgcggtga gccaagatcg caccattgca ctccagcctg ggcaacaaga gcgaaactct   3614

 gtctcaaaat aaataaaaaa taaaagacag aaagcaaggg gtgcctaaat ctagacttgg   3674

 ggtccacacc gggcagcggg gttgcaaccc agcacctggt aggctccatt tcttcccaag   3734

 cccgagcaga gggtcatgcg ggccccacag gagaagcggc cagggcccgc ggggggcacc   3794

 acctgtggac agccctcctg tccccaagct ttcaggcagg cactgaaacg caccgaactt   3854

 ccacgctctg ctggtcagtg gcggctgtcc cctccccagc ccagccgccc agccacatgt   3914

 gtctgcctga cccgtacaca ccaggggttc cggggttggg agctgaacca tccccacctc   3974

 agggttatat ttccctctcc ccttccctcc ccgccaagag ctctgccagg ggcgggcaaa   4034

 aaaaaaagta aaaagaaaag aaaaaaaaaa aaaaaaaaaa caaaccacct ctacatatta   4094

 tggaaagaaa atatttttgt cgattcttat tcttttataa ttatgcgtgg aagaagtaga   4154

 cacattaaac gattccagtt ggaaacatga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   4214

 aaaaaaaaaa aaaaaaaaaa aaaacaaaaa aaaaaaaaaa aaaaaaaaaa ataaaaaaaa   4274

 aaaaaaaaaa                                                          4284




      <210> 506
      <211> 4359
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (280)..(2919)

      <400> 506
 gaggccgccg cctgggtcgc tcaacttccg ggtcaaaggt gcctgagccg gcgggtcccc     60

 tgtgtccgcc gcggctgtcg tcccccgctc ccgccacttc cggggtcgca gtcccgggca    120

 tggagccgcg accgtgaggc gccgctggac ccgggacgac ctgcccagtc cggccgccgc    180

 cccacgtccc ggtctgtgtc ccacgcctgc agctggaatg gaggctctct ggacccttta    240

 gaaggcaccc ctgccctcct gaggtcagct gagcggtta   atg cgg aag gtt aag     294
                                              Met Arg Lys Val Lys
                                                1               5

 aaa ctg cgc ctg gac aag gag aac acc gga agt tgg aga agc ttc tcg      342
 Lys Leu Arg Leu Asp Lys Glu Asn Thr Gly Ser Trp Arg Ser Phe Ser
                  10                  15                  20

 ctg aat tcc gag ggg gct gag agg atg gcc acc acc ggg acc cca acg      390
 Leu Asn Ser Glu Gly Ala Glu Arg Met Ala Thr Thr Gly Thr Pro Thr
              25                  30                  35

 gcc gac cga ggc gac gca gcc gcc aca gat gac ccg gcc gcc cgc ttc      438
 Ala Asp Arg Gly Asp Ala Ala Ala Thr Asp Asp Pro Ala Ala Arg Phe
          40                  45                  50

 cag gtg cag aag cac tcg tgg gac ggg ctc cgg agc atc atc cac ggc      486
 Gln Val Gln Lys His Ser Trp Asp Gly Leu Arg Ser Ile Ile His Gly
      55                  60                  65

 agc cgc aag tac tcg ggc ctc att gtc aac aag gcg ccc cac gac ttc      534
 Ser Arg Lys Tyr Ser Gly Leu Ile Val Asn Lys Ala Pro His Asp Phe
  70                  75                  80                  85

 cag ttt gtg cag aag acg gat gag tct ggg ccc cac tcc cac cgc ctc      582
 Gln Phe Val Gln Lys Thr Asp Glu Ser Gly Pro His Ser His Arg Leu
                  90                  95                 100

 tac tac ctg gga atg cca tat ggc agc cga gag aac tcc ctc ctc tac      630
 Tyr Tyr Leu Gly Met Pro Tyr Gly Ser Arg Glu Asn Ser Leu Leu Tyr
             105                 110                 115

 tct gag att ccc aag aag gtc cgg aaa gag gct ctg ctg ctc ctg tcc      678
 Ser Glu Ile Pro Lys Lys Val Arg Lys Glu Ala Leu Leu Leu Leu Ser
         120                 125                 130

 tgg aag cag atg ctg gat cat ttc cag gcc acg ccc cac cat ggg gtc      726
 Trp Lys Gln Met Leu Asp His Phe Gln Ala Thr Pro His His Gly Val
     135                 140                 145

 tac tct cgg gag gag gag ctg ctg agg gag cgg aaa cgc ctg ggg gtc      774
 Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg Leu Gly Val
 150                 155                 160                 165

 ttc ggc atc acc tcc tac gac ttc cac agc gag agt ggc ctc ttc ctc      822
 Phe Gly Ile Thr Ser Tyr Asp Phe His Ser Glu Ser Gly Leu Phe Leu
                 170                 175                 180

 ttc cag gcc agc aac agc ctc ttc cac tgc cgc gac ggc ggc aag aac      870
 Phe Gln Ala Ser Asn Ser Leu Phe His Cys Arg Asp Gly Gly Lys Asn
             185                 190                 195

 ggc ttc atg gtg tcc cct atg aaa ccg ctg gaa atc aag acc cag tgc      918
 Gly Phe Met Val Ser Pro Met Lys Pro Leu Glu Ile Lys Thr Gln Cys
         200                 205                 210

 tca ggg ccc cgg atg gac ccc aaa atc tgc cct gcc gac cct gcc ttc      966
 Ser Gly Pro Arg Met Asp Pro Lys Ile Cys Pro Ala Asp Pro Ala Phe
     215                 220                 225

 ttc tcc ttc atc aat aac agc gac ctg tgg gtg gcc aac atc gag aca     1014
 Phe Ser Phe Ile Asn Asn Ser Asp Leu Trp Val Ala Asn Ile Glu Thr
 230                 235                 240                 245

 ggc gag gag cgg cgg ctg acc ttc tgc cac caa ggt tta tcc aat gtc     1062
 Gly Glu Glu Arg Arg Leu Thr Phe Cys His Gln Gly Leu Ser Asn Val
                 250                 255                 260

 ctg gat gac ccc aag tct gcg ggt gtg gcc acc ttc gtc ata cag gaa     1110
 Leu Asp Asp Pro Lys Ser Ala Gly Val Ala Thr Phe Val Ile Gln Glu
             265                 270                 275

 gag ttc gac cgc ttc act ggg tac tgg tgg tgc ccc aca gcc tcc tgg     1158
 Glu Phe Asp Arg Phe Thr Gly Tyr Trp Trp Cys Pro Thr Ala Ser Trp
         280                 285                 290

 gaa ggt tca gag ggc ctc aag acg ctg cga atc ctg tat gag gaa gtc     1206
 Glu Gly Ser Glu Gly Leu Lys Thr Leu Arg Ile Leu Tyr Glu Glu Val
     295                 300                 305

 gat gag tcc gag gtg gag gtc att cac gtc ccc tct cct gcg cta gaa     1254
 Asp Glu Ser Glu Val Glu Val Ile His Val Pro Ser Pro Ala Leu Glu
 310                 315                 320                 325

 gaa agg aag acg gac tcg tat cgg tac ccc agg aca ggc agc aag aat     1302
 Glu Arg Lys Thr Asp Ser Tyr Arg Tyr Pro Arg Thr Gly Ser Lys Asn
                 330                 335                 340

 ccc aag att gcc ttg aaa ctg gct gag ttc cag act gac agc cag ggc     1350
 Pro Lys Ile Ala Leu Lys Leu Ala Glu Phe Gln Thr Asp Ser Gln Gly
             345                 350                 355

 aag atc gtc tcg acc cag gag aag gag ctg gtg cag ccc ttc agc tcg     1398
 Lys Ile Val Ser Thr Gln Glu Lys Glu Leu Val Gln Pro Phe Ser Ser
         360                 365                 370

 ctg ttc ccg aag gtg gag tac atc gcc agg gcc ggg tgg acc cgg gat     1446
 Leu Phe Pro Lys Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr Arg Asp
     375                 380                 385

 ggc aaa tac gcc tgg gcc atg ttc ctg gac cgg ccc cag cag tgg ctc     1494
 Gly Lys Tyr Ala Trp Ala Met Phe Leu Asp Arg Pro Gln Gln Trp Leu
 390                 395                 400                 405

 cag ctc gtc ctc ctc ccc ccg gcc ctg ttc atc ccg agc aca gag aat     1542
 Gln Leu Val Leu Leu Pro Pro Ala Leu Phe Ile Pro Ser Thr Glu Asn
                 410                 415                 420

 gag gag cag cgg cta gcc tct gcc aga gct gtc ccc agg aat gtc cag     1590
 Glu Glu Gln Arg Leu Ala Ser Ala Arg Ala Val Pro Arg Asn Val Gln
             425                 430                 435

 ccg tat gtg gtg tac gag gag gtc acc aac gtc tgg atc aat gtt cat     1638
 Pro Tyr Val Val Tyr Glu Glu Val Thr Asn Val Trp Ile Asn Val His
         440                 445                 450

 gac atc ttc tat ccc ttc ccc caa tca gag gga gag gac gag ctc tgc     1686
 Asp Ile Phe Tyr Pro Phe Pro Gln Ser Glu Gly Glu Asp Glu Leu Cys
     455                 460                 465

 ttt ctc cgc gcc aat gaa tgc aag acc ggc ttc tgc cat ttg tac aaa     1734
 Phe Leu Arg Ala Asn Glu Cys Lys Thr Gly Phe Cys His Leu Tyr Lys
 470                 475                 480                 485

 gtc acc gcc gtt tta aaa tcc cag ggc tac gat tgg agt gag ccc ttc     1782
 Val Thr Ala Val Leu Lys Ser Gln Gly Tyr Asp Trp Ser Glu Pro Phe
                 490                 495                 500

 agc ccc ggg gaa gat gaa ttt aag tgc ccc att aag gaa gag att gct     1830
 Ser Pro Gly Glu Asp Glu Phe Lys Cys Pro Ile Lys Glu Glu Ile Ala
             505                 510                 515

 ctg acc agc ggt gaa tgg gag gtt ttg gcg agg cac ggc tcc aag ggc     1878
 Leu Thr Ser Gly Glu Trp Glu Val Leu Ala Arg His Gly Ser Lys Gly
         520                 525                 530

 acc aag gac acg ccg ctg gag cac cac ctc tac gtg gtc agc tat gag     1926
 Thr Lys Asp Thr Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Glu
     535                 540                 545

 gcg gcc ggc gag atc gta cgc ctc acc acg ccc ggc ttc tcc cat agc     1974
 Ala Ala Gly Glu Ile Val Arg Leu Thr Thr Pro Gly Phe Ser His Ser
 550                 555                 560                 565

 tgc tcc atg agc cag aac ttc gac atg ttc gtc agc cac tac agc agc     2022
 Cys Ser Met Ser Gln Asn Phe Asp Met Phe Val Ser His Tyr Ser Ser
                 570                 575                 580

 gtg agc acg ccg ccc tgc gtg cac gtc tac aag ctg agc ggc ccc gac     2070
 Val Ser Thr Pro Pro Cys Val His Val Tyr Lys Leu Ser Gly Pro Asp
             585                 590                 595

 gac gac ccc ctg cac aag cag ccc cgc ttc tgg gct agc atg atg gag     2118
 Asp Asp Pro Leu His Lys Gln Pro Arg Phe Trp Ala Ser Met Met Glu
         600                 605                 610

 gca gcc agc tgc ccc ccg gat tat gtt cct cca gag atc ttc cat ttc     2166
 Ala Ala Ser Cys Pro Pro Asp Tyr Val Pro Pro Glu Ile Phe His Phe
     615                 620                 625

 cac acg cgc tcg gat gtg cgg ctc tac ggc atg atc tac aag ccc cac     2214
 His Thr Arg Ser Asp Val Arg Leu Tyr Gly Met Ile Tyr Lys Pro His
 630                 635                 640                 645

 gcc ttg cag cca ggg aag aag cac ccc acc gtc ctc ttt gta tat gga     2262
 Ala Leu Gln Pro Gly Lys Lys His Pro Thr Val Leu Phe Val Tyr Gly
                 650                 655                 660

 ggc ccc cag gtg cag ctg gtg aat aac tcc ttc aaa ggc atc aag tac     2310
 Gly Pro Gln Val Gln Leu Val Asn Asn Ser Phe Lys Gly Ile Lys Tyr
             665                 670                 675

 ttg cgg ctc aac aca ctg gcc tcc ctg ggc tac gcc gtg gtt gtg att     2358
 Leu Arg Leu Asn Thr Leu Ala Ser Leu Gly Tyr Ala Val Val Val Ile
         680                 685                 690

 gac ggc agg ggc tcc tgt cag cga ggg ctt cgg ttc gaa ggg gcc ctg     2406
 Asp Gly Arg Gly Ser Cys Gln Arg Gly Leu Arg Phe Glu Gly Ala Leu
     695                 700                 705

 aaa aac caa atg ggc cag gtg gag atc gag gac cag gtg gag ggc ctg     2454
 Lys Asn Gln Met Gly Gln Val Glu Ile Glu Asp Gln Val Glu Gly Leu
 710                 715                 720                 725

 cag ttc gtg gcc gag aag tat ggc ttc atc gac ctg agc cga gtt gcc     2502
 Gln Phe Val Ala Glu Lys Tyr Gly Phe Ile Asp Leu Ser Arg Val Ala
                 730                 735                 740

 atc cat ggc tgg tcc tac ggg ggc ttc ctc tcg ctc atg ggg cta atc     2550
 Ile His Gly Trp Ser Tyr Gly Gly Phe Leu Ser Leu Met Gly Leu Ile
             745                 750                 755

 cac aag ccc cag gtg ttc aag gtg gcc atc gcg ggt gcc ccg gtc acc     2598
 His Lys Pro Gln Val Phe Lys Val Ala Ile Ala Gly Ala Pro Val Thr
         760                 765                 770

 gtc tgg atg gcc tac gac aca ggg tac act gag cgc tac atg gac gtc     2646
 Val Trp Met Ala Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met Asp Val
     775                 780                 785

 cct gag aac aac cag cac ggc tat gag gcg ggt tcc gtg gcc ctg cac     2694
 Pro Glu Asn Asn Gln His Gly Tyr Glu Ala Gly Ser Val Ala Leu His
 790                 795                 800                 805

 gtg gag aag ctg ccc aat gag ccc aac cgc ttg ctt atc ctc cac ggc     2742
 Val Glu Lys Leu Pro Asn Glu Pro Asn Arg Leu Leu Ile Leu His Gly
                 810                 815                 820

 ttc ctg gac gaa aac gtg cac ttt ttc cac aca aac ttc ctc gtc tcc     2790
 Phe Leu Asp Glu Asn Val His Phe Phe His Thr Asn Phe Leu Val Ser
             825                 830                 835

 caa ctg atc cga gca ggg aaa cct tac cag ctc cag atc tac ccc aac     2838
 Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln Leu Gln Ile Tyr Pro Asn
         840                 845                 850

 gag aga cac agt att cgc tgc ccc gag tcg ggc gag cac tat gaa gtc     2886
 Glu Arg His Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr Glu Val
     855                 860                 865

 acg ttg ctg cac ttt cta cag gaa tac ctc tga gcctgccc accgggagcc     2937
 Thr Leu Leu His Phe Leu Gln Glu Tyr Leu 
 870                 875

 gccacatcac agcacaagtg gctgcagcct ccgcggggaa ccaggcggga gggactgagt   2997

 ggcccgcggg ccccagtgag gcactttgtc ccgcccagcg ctggccagcc ccgaggagcc   3057

 gctgccttca ccgccccgac gccttttatc cttttttaaa cgctcttggg ttttatgtcc   3117

 gctgcttctt ggttgccgag acagagagat ggtggtctcg ggccagcccc tcctctcccc   3177

 gccttctggg aggaggaggt cacacgctga tgggcactgg agaggccaga agagactcag   3237

 aggagcgggc tgccttccgc ctggggctcc ctgtgacctc tcagtcccct ggcccggcca   3297

 gccaccgtcc ccagcaccca agcatgcaat tgcctgtccc ccccggccag cctccccaac   3357

 ttgatgtttg tgttttgttt ggggggatat ttttcataat tatttaaaag acaggccggg   3417

 cgcggtggct cacgtctgta atcccagcac tttgggaggc tgaggcgggc ggatcacctg   3477

 aggttgggag ttcaagacca gcctggccaa catggggaaa ccccgtctct actaaaaata   3537

 caaaaaatta gccgggtgtg gtggcgcgtg cctataatcc cagctactcg ggaggctgag   3597

 gcaggagaat cgcttgaacc cgggaggtgg aggttgcggt gagccaagat cgcaccattg   3657

 cactccagcc tgggcaacaa gagcgaaact ctgtctcaaa ataaataaaa aataaaagac   3717

 agaaagcaag gggtgcctaa atctagactt ggggtccaca ccgggcagcg gggttgcaac   3777

 ccagcacctg gtaggctcca tttcttccca agcccgagca gagggtcatg cgggccccac   3837

 aggagaagcg gccagggccc gcggggggca ccacctgtgg acagccctcc tgtccccaag   3897

 ctttcaggca ggcactgaaa cgcaccgaac ttccacgctc tgctggtcag tggcggctgt   3957

 cccctcccca gcccagccgc ccagccacat gtgtctgcct gacccgtaca caccaggggt   4017

 tccggggttg ggagctgaac catccccacc tcagggttat atttccctct ccccttccct   4077

 ccccgccaag agctctgcca ggggcgggca aaaaaaaaag taaaaagaaa agaaaaaaaa   4137

 aaaaaaaaaa aacaaaccac ctctacatat tatggaaaga aaatattttt gtcgattctt   4197

 attcttttat aattatgcgt ggaagaagta gacacattaa acgattccag ttggaaacat   4257

 gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaacaaa   4317

 aaaaaaaaaa aaaaaaaaaa aaataaaaaa aaaaaaaaaa aa                      4359




      <210> 507
      <211> 832
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (471)..(809)

      <400> 507
 gatttaataa agttttattt ttccaaatgt acagctggtt ggacctattc atgcatcttc     60

 accagcagct ggagcatctc cacccttggt atttctggtg taaattactt gagctctgtg    120

 ctttgaaacc agtttgataa gtcctttact aaggagctcc tgaagggctg ccctggccag    180

 ggagcctcga atcttcagtc tctcagagac cacagctggg gttataagtt tatagttggg    240

 aacttcctta cagagtttat cataggtagc tttgtcaaac aagactaagt tattgagctt    300

 gtcccgaact ttgcctttgg accacttctt ctttttggcc ttgcccccgg atttgttcac    360

 tgggtctttg tctttcttgg ccgactttcc agcgtccttc ttcttcttgt cgtccttagg    420

 cggcattgcg aagctcggag aatagcagca gacaccgcag cctcgtcaag   atg tcg     476
                                                          Met Ser
                                                            1

 gac aaa aaa gac aaa gac cca gtg aac aaa tcc ggg ggc aag gcc aaa      524
 Asp Lys Lys Asp Lys Asp Pro Val Asn Lys Ser Gly Gly Lys Ala Lys
           5                  10                  15

 aag aag aag tgg tcc aaa ggc aaa gtt cgg gac aag ctc aat aac tta      572
 Lys Lys Lys Trp Ser Lys Gly Lys Val Arg Asp Lys Leu Asn Asn Leu
      20                  25                  30

 gtc ttg ttt gac aaa gct acc tat gat aaa ctc tgt aag gaa gtt ccc      620
 Val Leu Phe Asp Lys Ala Thr Tyr Asp Lys Leu Cys Lys Glu Val Pro
  35                  40                  45                  50

 aac tat aaa ctt ata acc cca gct gtg gtc tct gag aga ctg aag att      668
 Asn Tyr Lys Leu Ile Thr Pro Ala Val Val Ser Glu Arg Leu Lys Ile
                  55                  60                  65

 cga ggc tcc ctg gcc agg gca gcc ctt cag gag ctc ctt agt aaa gga      716
 Arg Gly Ser Leu Ala Arg Ala Ala Leu Gln Glu Leu Leu Ser Lys Gly
              70                  75                  80

 ctt atc aaa ctg gtt tca aag cac aga gct caa gta att tac acc aga      764
 Leu Ile Lys Leu Val Ser Lys His Arg Ala Gln Val Ile Tyr Thr Arg
          85                  90                  95

 aat acc aag ggt gga gat gct cca gct gct ggt gaa gat gca tga ata      812
 Asn Thr Lys Gly Gly Asp Ala Pro Ala Ala Gly Glu Asp Ala 
     100                 105                 110

 ggtccaacca gctgtacatt                                                832




      <210> 508
      <211> 2025
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(460)

      <400> 508
 atcaataggc acattccaat gagcaaaccc caggaatcca cctgttctca tcttgccaac     60

 a    atg ctc ctt cca cgg aaa ctg acc ctg tcc tat ttc ctc gct ttg     106
      Met Leu Leu Pro Arg Lys Leu Thr Leu Ser Tyr Phe Leu Ala Leu
        1               5                  10                  15

 atc att gcc cag aag gaa cag gga ctg ttg aga aac aga ggc agc gtg      154
 Ile Ile Ala Gln Lys Glu Gln Gly Leu Leu Arg Asn Arg Gly Ser Val
                  20                  25                  30

 cag cct gaa ggc atg cac cgt gca gaa gag gat ccc tgc ggc tgc ggg      202
 Gln Pro Glu Gly Met His Arg Ala Glu Glu Asp Pro Cys Gly Cys Gly
              35                  40                  45

 ctc ttt tcc agg ccc aag gac aag gcg gtg tgt gcc ggg ttg atc tgc      250
 Leu Phe Ser Arg Pro Lys Asp Lys Ala Val Cys Ala Gly Leu Ile Cys
          50                  55                  60

 act gct tta gcc agg atg gct ctt ctt aga gag aca aac cgc tcc aac      298
 Thr Ala Leu Ala Arg Met Ala Leu Leu Arg Glu Thr Asn Arg Ser Asn
      65                  70                  75

 gcc aaa ctg ccc tcg caa ttc caa tcg caa agg cag gct agg gcc aca      346
 Ala Lys Leu Pro Ser Gln Phe Gln Ser Gln Arg Gln Ala Arg Ala Thr
  80                  85                  90                  95

 gtt caa acc caa ctg cca atg tcc aca aag aaa aga aga aag ctg gaa      394
 Val Gln Thr Gln Leu Pro Met Ser Thr Lys Lys Arg Arg Lys Leu Glu
                 100                 105                 110

 atg cag ttg gtc ttg cca tgc tgg ccg ctc agc ttc tca ccc cca ggc      442
 Met Gln Leu Val Leu Pro Cys Trp Pro Leu Ser Phe Ser Pro Pro Gly
             115                 120                 125

 cta aga agg aca agg tga ggatga gttccattta cagagtcctc accaggtgcc      496
 Leu Arg Arg Thr Arg 
         130

 agtcacgatc tcaatgtctc acagctgcca tcccgccagg ctcccaggag gaaggtgctg    556

 ctatttatta tccacaggac agaccccaca gctggcaagt ggctgggcca ggaaccagct    616

 agggcaggtt tgtcccatac tctctaccca tgagcacgag gctgtgctgt tcatgtctcc    676

 attcaaacac aggctgatat ttccactcca ggggaaaaaa ggtagaaaaa aaaatatata    736

 tatgtatgta tatacatttg agacagagtc tcactctgtt gcccaggctg gagtgcagtg    796

 gcaggatcac agctcactgt agtctggact tcccaggctt aaaggatcct ccctcctcag    856

 cctcctaagt agctgggact acaggcacac gccgccatgc caggttcatt tttaaatttt    916

 tttgtagaga cagtgtctcg ctatgttgcc cagcctggtc tcgaactcct gacatcgaga    976

 tccacctacc ttggcctccc aaagtgctgg gattacaggc atgagtcacc gcgcccaatc   1036

 ctccaccagc aattttcatt ctgcttttac caataagaac cagagtcatc tgaatcactg   1096

 ggatgcacag agtattacat actttaactg tgtattttag ttaactgaca ggacttcctt   1156

 caaaggcaaa tgcctgcaga ccatcatctt cctctactgg gccatcctag tcatcattct   1216

 ggaaaactct gttcttttgc ccaatagctt cacacgctgt ggtccagggc tctctctcac   1276

 aaacagcttg actgccgcaa ccttcacacc atgggggcct gtgagacacc ccacgtggat   1336

 gggttggggc catggcacag gtctcgaggg tcctgggtgc taaagactgt gcagaaggac   1396

 ggggtctgac cagtgaagca gccggcaaca tctgcagaca gtcactggct ccaacttttg   1456

 tttttgtcac tgtgtcaccc aggctggagt gcagtggtgc gacctcagct cattgcaacc   1516

 tccgcctcct gggttcaagt gattctcctg cctcagcctc ccgagtagct gggattacag   1576

 gcaggcacca ccacgcctgg ctaatttttt gtatttttag tagcgatggg gtttcatcat   1636

 gttggccagg ctggtctcaa acaactgacc tcaggtgatc cacctgcctc ggcctcccaa   1696

 agggctggga ttacgggcgt gagccaccgc gcctggcctc catttatttg taaataggta   1756

 attctcaaca gtatgtttac tctggataaa catcagtcag tgcgtagaac tggtaaatgt   1816

 cagagaaatg tatcacttat cagagcgtct cacagtctag tcctgtattt cttctgaact   1876

 cacgctctgc aaagccaggg ctgaatgtat ctaccatacc tgcttgttta cctccaaacc   1936

 ttgcaataca tttatacaaa atatttattt cacagcttat cttaaaacaa atgtaaaagg   1996

 tatcttcaaa taaatcagac tgaatctct                                     2025




      <210> 509
      <211> 3526
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (86)..(3097)

      <400> 509
 tcgggagcca gattttgtcc cttctcctgg caatcccttc cgcttccccg gctcccggcg     60

 tgacatctgc gggccgggga cctgc  atg tgt gtg cgc gcg aag gag cgg aag     112
                              Met Cys Val Arg Ala Lys Glu Arg Lys
                                1               5

 aat ggc agt gct caa act cac cga cca gcc acc atg gtt cag gca atc      160
 Asn Gly Ser Ala Gln Thr His Arg Pro Ala Thr Met Val Gln Ala Ile
  10                  15                  20                  25

 ttc agc ggt gat cca gag gag atc cgg atg ctc atc cat aaa act gaa      208
 Phe Ser Gly Asp Pro Glu Glu Ile Arg Met Leu Ile His Lys Thr Glu
                  30                  35                  40

 gat gtg aat act ctg gat tct gag aaa cga acc cct ctt cat gtg gcc      256
 Asp Val Asn Thr Leu Asp Ser Glu Lys Arg Thr Pro Leu His Val Ala
              45                  50                  55

 gca ttt ctg gga gat gca gag atc att gaa ctc ctg att ttg tca gga      304
 Ala Phe Leu Gly Asp Ala Glu Ile Ile Glu Leu Leu Ile Leu Ser Gly
          60                  65                  70

 gct cgt gta aat gcc aag gac aac atg tgg ctg act cca ctg cac cgg      352
 Ala Arg Val Asn Ala Lys Asp Asn Met Trp Leu Thr Pro Leu His Arg
      75                  80                  85

 gct gtt gct tcc aga agc gaa gaa gca gta cag gtt ttg att aag cac      400
 Ala Val Ala Ser Arg Ser Glu Glu Ala Val Gln Val Leu Ile Lys His
  90                  95                 100                 105

 tca gct gat gtc aat gca agg gac aag aac tgg cag acc cct ctt cat      448
 Ser Ala Asp Val Asn Ala Arg Asp Lys Asn Trp Gln Thr Pro Leu His
                 110                 115                 120

 gtg gca gca gcc aac aag gct gtc aaa tgt gca gaa gtg atc att ccc      496
 Val Ala Ala Ala Asn Lys Ala Val Lys Cys Ala Glu Val Ile Ile Pro
             125                 130                 135

 ctg ctg agc agt gtc aat gtc tcc gac cga ggg ggg cgc aca gcc ttg      544
 Leu Leu Ser Ser Val Asn Val Ser Asp Arg Gly Gly Arg Thr Ala Leu
         140                 145                 150

 cac cat gcg gct ctg aac ggc cac gtg gag atg gtc aat tta ctc ttg      592
 His His Ala Ala Leu Asn Gly His Val Glu Met Val Asn Leu Leu Leu
     155                 160                 165

 gcc aaa ggg gca aat atc aat gca ttt gac aag aag gac cgg cgt gct      640
 Ala Lys Gly Ala Asn Ile Asn Ala Phe Asp Lys Lys Asp Arg Arg Ala
 170                 175                 180                 185

 ctg cac tgg gca gca tac atg ggc cac ttg gat gtt gta gca ttg ctc      688
 Leu His Trp Ala Ala Tyr Met Gly His Leu Asp Val Val Ala Leu Leu
                 190                 195                 200

 att aac cat ggc gca gaa gtg acc tgt aag gat aag aag ggt tat acc      736
 Ile Asn His Gly Ala Glu Val Thr Cys Lys Asp Lys Lys Gly Tyr Thr
             205                 210                 215

 cct ctg cat gct gca gcc tcc aat gga cag att aat gtt gtc aag cat      784
 Pro Leu His Ala Ala Ala Ser Asn Gly Gln Ile Asn Val Val Lys His
         220                 225                 230

 ctc ctg aac ctg ggg gtg gag att gat gaa atc aat gtc tat gga aat      832
 Leu Leu Asn Leu Gly Val Glu Ile Asp Glu Ile Asn Val Tyr Gly Asn
     235                 240                 245

 aca gcg ctt cac atc gcc tgc tac aat gga cag gat gct gtg gtt aac      880
 Thr Ala Leu His Ile Ala Cys Tyr Asn Gly Gln Asp Ala Val Val Asn
 250                 255                 260                 265

 gag ttg att gac tac ggt gct aac gtg aac cag cca aac aat aat ggg      928
 Glu Leu Ile Asp Tyr Gly Ala Asn Val Asn Gln Pro Asn Asn Asn Gly
                 270                 275                 280

 ttc acc cct ttg cat ttt gct gct gcc tcc act cat ggt gct ttg tgt      976
 Phe Thr Pro Leu His Phe Ala Ala Ala Ser Thr His Gly Ala Leu Cys
             285                 290                 295

 ctt gaa ttg tta gta aac aac ggg gca gat gtt aac att cag agt aaa     1024
 Leu Glu Leu Leu Val Asn Asn Gly Ala Asp Val Asn Ile Gln Ser Lys
         300                 305                 310

 gat ggc aaa agt cca ctg cac atg aca gct gtc cat gga agg ttc aca     1072
 Asp Gly Lys Ser Pro Leu His Met Thr Ala Val His Gly Arg Phe Thr
     315                 320                 325

 cgg tca cag acc ctc att cag aat gga ggt gaa att gac tgt gtg gat     1120
 Arg Ser Gln Thr Leu Ile Gln Asn Gly Gly Glu Ile Asp Cys Val Asp
 330                 335                 340                 345

 aag gac ggc aac act cct ctc cat gtg gct gca aga tac ggt cat gag     1168
 Lys Asp Gly Asn Thr Pro Leu His Val Ala Ala Arg Tyr Gly His Glu
                 350                 355                 360

 ctt ttg att aac acc tta ata acc agc gga gct gac aca gcc aag tgt     1216
 Leu Leu Ile Asn Thr Leu Ile Thr Ser Gly Ala Asp Thr Ala Lys Cys
             365                 370                 375

 gga atc cat agc atg ttc cct tta cat tta gct gcc cta aat gct cac     1264
 Gly Ile His Ser Met Phe Pro Leu His Leu Ala Ala Leu Asn Ala His
         380                 385                 390

 tct gac tgc tgc aga aag ttg tta tca tcg gga caa aag tat agc ata     1312
 Ser Asp Cys Cys Arg Lys Leu Leu Ser Ser Gly Gln Lys Tyr Ser Ile
     395                 400                 405

 gta tcc ttg ttt agt aat gag cac gtg ctg tct gca ggc ttt gaa ata     1360
 Val Ser Leu Phe Ser Asn Glu His Val Leu Ser Ala Gly Phe Glu Ile
 410                 415                 420                 425

 gac acc cca gat aaa ttt gga aga acg tgc ctt cat gct gct gct gca     1408
 Asp Thr Pro Asp Lys Phe Gly Arg Thr Cys Leu His Ala Ala Ala Ala
                 430                 435                 440

 gga ggt aat gtg gaa tgt ata aaa ctc ttg cag agc agc gga gca gat     1456
 Gly Gly Asn Val Glu Cys Ile Lys Leu Leu Gln Ser Ser Gly Ala Asp
             445                 450                 455

 ttc cat aaa aag gac aag tgt ggg agg acc cct ttg cac tat gca gct     1504
 Phe His Lys Lys Asp Lys Cys Gly Arg Thr Pro Leu His Tyr Ala Ala
         460                 465                 470

 gcg aat tgt cat ttc cac tgt att gag aca tta gtg acc aca ggg gcc     1552
 Ala Asn Cys His Phe His Cys Ile Glu Thr Leu Val Thr Thr Gly Ala
     475                 480                 485

 aac gtt aat gaa aca gat gac tgg gga cgc aca gct ttg cat tac gcc     1600
 Asn Val Asn Glu Thr Asp Asp Trp Gly Arg Thr Ala Leu His Tyr Ala
 490                 495                 500                 505

 gct gca tca gac atg gat aga aat aag act atc tta gga aat gcc cat     1648
 Ala Ala Ser Asp Met Asp Arg Asn Lys Thr Ile Leu Gly Asn Ala His
                 510                 515                 520

 gat aat tca gaa gaa ctt gaa aga gcc agg gag ctg aag gaa aag gaa     1696
 Asp Asn Ser Glu Glu Leu Glu Arg Ala Arg Glu Leu Lys Glu Lys Glu
             525                 530                 535

 gcc aca cta tgt cta gag ttt ctg ctt caa aat gat gca aat cca tct     1744
 Ala Thr Leu Cys Leu Glu Phe Leu Leu Gln Asn Asp Ala Asn Pro Ser
         540                 545                 550

 atc cgg gac aag gaa ggt tac aat agc ata cat tat gct gcc gcc tat     1792
 Ile Arg Asp Lys Glu Gly Tyr Asn Ser Ile His Tyr Ala Ala Ala Tyr
     555                 560                 565

 ggg cac agg cag tgt ctg gaa ttg ctt ttg gaa aga aca aac agt gga     1840
 Gly His Arg Gln Cys Leu Glu Leu Leu Leu Glu Arg Thr Asn Ser Gly
 570                 575                 580                 585

 ttt gaa gaa tca gat tct ggt gct act aag agt cca ctc cac tta gct     1888
 Phe Glu Glu Ser Asp Ser Gly Ala Thr Lys Ser Pro Leu His Leu Ala
                 590                 595                 600

 gcc tac aat ggg cac cat caa gcc ttg gaa gtc ctt ctg cag tcg ttg     1936
 Ala Tyr Asn Gly His His Gln Ala Leu Glu Val Leu Leu Gln Ser Leu
             605                 610                 615

 gtg gac ctg gac atc agg gat gag aaa ggc cgc act gct ctg gat ctg     1984
 Val Asp Leu Asp Ile Arg Asp Glu Lys Gly Arg Thr Ala Leu Asp Leu
         620                 625                 630

 gct gcc ttt aaa gga cac aca gaa tgt gtg gaa gcg ctt atc aat cag     2032
 Ala Ala Phe Lys Gly His Thr Glu Cys Val Glu Ala Leu Ile Asn Gln
     635                 640                 645

 ggc gca tcc atc ttt gtg aaa gac aat gta acc aaa aga acc cca ctt     2080
 Gly Ala Ser Ile Phe Val Lys Asp Asn Val Thr Lys Arg Thr Pro Leu
 650                 655                 660                 665

 cat gcc tca gta att aat ggt cac aca ctg tgt tta cgg ctg ttg cta     2128
 His Ala Ser Val Ile Asn Gly His Thr Leu Cys Leu Arg Leu Leu Leu
                 670                 675                 680

 gaa att gca gac aac ccg gag gcg gtc gat gtg aaa gat gcc aaa gga     2176
 Glu Ile Ala Asp Asn Pro Glu Ala Val Asp Val Lys Asp Ala Lys Gly
             685                 690                 695

 caa aca cca ctg atg ctt gca gta gca tat gga cat att gac gct gtt     2224
 Gln Thr Pro Leu Met Leu Ala Val Ala Tyr Gly His Ile Asp Ala Val
         700                 705                 710

 tca ttg tta ctt gaa aag gaa gcc aac gta gac act gtt gac atc cta     2272
 Ser Leu Leu Leu Glu Lys Glu Ala Asn Val Asp Thr Val Asp Ile Leu
     715                 720                 725

 gga tgc aca gct tta cac aga ggg att atg aca gga cac gag gaa tgt     2320
 Gly Cys Thr Ala Leu His Arg Gly Ile Met Thr Gly His Glu Glu Cys
 730                 735                 740                 745

 gtg caa atg ctg ctg gaa caa gaa gtg tca att ctc tgt aaa gat tcc     2368
 Val Gln Met Leu Leu Glu Gln Glu Val Ser Ile Leu Cys Lys Asp Ser
                 750                 755                 760

 aga ggg agg acg ccc ttg cac tat gca gct gct cgt ggc cac gcc acg     2416
 Arg Gly Arg Thr Pro Leu His Tyr Ala Ala Ala Arg Gly His Ala Thr
             765                 770                 775

 tgg ctg agc gag ctg ctc caa atg gct ctt tct gag gag gac tgt tgt     2464
 Trp Leu Ser Glu Leu Leu Gln Met Ala Leu Ser Glu Glu Asp Cys Cys
         780                 785                 790

 ttc aaa gat aac caa ggc tac acg ccg ctg cac tgg gct tgt tac aat     2512
 Phe Lys Asp Asn Gln Gly Tyr Thr Pro Leu His Trp Ala Cys Tyr Asn
     795                 800                 805

 ggt aat gaa aac tgt ata gag gta ctt ttg gag caa aaa tgt ttt cgc     2560
 Gly Asn Glu Asn Cys Ile Glu Val Leu Leu Glu Gln Lys Cys Phe Arg
 810                 815                 820                 825

 aaa ttt atc ggt aat ccc ttt act cca ctg cac tgt gca ata atc aat     2608
 Lys Phe Ile Gly Asn Pro Phe Thr Pro Leu His Cys Ala Ile Ile Asn
                 830                 835                 840

 gat cat ggg aat tgt gca tca ttg ctg ctt ggg gcc ata gat tcc agt     2656
 Asp His Gly Asn Cys Ala Ser Leu Leu Leu Gly Ala Ile Asp Ser Ser
             845                 850                 855

 atc gtc agt tgt aga gat gac aaa ggc agg aca ccc ctt cat gcg gca     2704
 Ile Val Ser Cys Arg Asp Asp Lys Gly Arg Thr Pro Leu His Ala Ala
         860                 865                 870

 gca ttt gct gat cat gtg gag tgc ttg cag ctt ctt ctg aga cac agt     2752
 Ala Phe Ala Asp His Val Glu Cys Leu Gln Leu Leu Leu Arg His Ser
     875                 880                 885

 gct cca gtg aac gca gta gat aat tca ggg aaa aca gca ctg atg atg     2800
 Ala Pro Val Asn Ala Val Asp Asn Ser Gly Lys Thr Ala Leu Met Met
 890                 895                 900                 905

 gct gct gag aat ggg cag gca ggc gct gtg gat att ttg gtg aac agt     2848
 Ala Ala Glu Asn Gly Gln Ala Gly Ala Val Asp Ile Leu Val Asn Ser
                 910                 915                 920

 gcc cag gct gat ctg act gta aag gat aag gac ttg aat aca ccc tta     2896
 Ala Gln Ala Asp Leu Thr Val Lys Asp Lys Asp Leu Asn Thr Pro Leu
             925                 930                 935

 cat ttg gct tgt agt aaa ggt cat gaa aaa tgt gcc ttg tta ata ctt     2944
 His Leu Ala Cys Ser Lys Gly His Glu Lys Cys Ala Leu Leu Ile Leu
         940                 945                 950

 gac aag ata caa gac gag agc ctt att aat gaa aaa aat aat gca ctg     2992
 Asp Lys Ile Gln Asp Glu Ser Leu Ile Asn Glu Lys Asn Asn Ala Leu
     955                 960                 965

 cag aca ccc ctc cac gtc gct gcg cgc aat ggc tta aag gtg gta gtt     3040
 Gln Thr Pro Leu His Val Ala Ala Arg Asn Gly Leu Lys Val Val Val
 970                 975                 980                 985

 gag gag ttg ctg gcc aaa ggg gcc tgt gta ctt gct gta gat gaa aat     3088
 Glu Glu Leu Leu Ala Lys Gly Ala Cys Val Leu Ala Val Asp Glu Asn
                 990                 995                1000

 ggc tgt taa ccattca agatccaaga acatcggttg gctgcaaaac aggcaccctg     3144
 Gly Cys 


 agggaccaat tatgaatcag aatgcacttt atcccagcca cagaacgcaa agggttacac   3204

 tctgcaggag ctgcggttgg ggaagggaaa gggagtaacc ggattcgcct tgcctgtctg   3264

 tgattgggaa gcacgcaccc tttattttcc aactgggaac aagatactgg aaattcctct   3324

 ttcccttaga aaacagaagg caagggtgtt ggctgtggaa attagaactg ggtaatagtt   3384

 ctagagcact ttgaaattct ttcaggataa gtgttatacg aacacaaatg atttctttca   3444

 ttgttaaatt gtgttcctat cattggtaac gccccaagta aagccttttt aattaaaaat   3504

 ctctggatgc tataaaaaaa aa                                            3526




      <210> 510
      <211> 2090
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (603)..(1883)

      <400> 510
 cgtggatccc gagaaagagg cgcaggacga ggaggcagaa cccgactggc gcgtagagca     60

 gcagcacgag cagtaggaag cagtcacccg gaagcctggg ggcgagaggc gaagtggtca    120

 ggcgccgaag gccgagagca cgcggggatc ggtctcttcc cgccgggtct cttaccggtg    180

 cgagtcaaag agccgctccg gccccggccc tgagggaagc tccataactg ctgcttcagg    240

 agcgcccggc cgtcgccgcc gccgccattt tcgcgcccgg ccgcaggggc tcttgggaag    300

 gcggagtctt tgggcatccg cccggggtga ggggacccga agtcctgagg cgcgccggaa    360

 gggctagcgg tcccagcata ccccgcggcc ccttgggccg tctcacaact cgcgtccggc    420

 ggagaccaca attcccggca ttcgtggggc agggaggagt cggcctcccg gaatcctggt    480

 cccggcgtgc acttctgaag gacttcaggt accggcgtgc cccgcgtcct actgtccgcc    540

 tgctcgcgtc ctgggtgccg cctctgagta gggcgggcga ggaggcagcc aaggcggagc    600

 tg   atg gct gcg ccg agg gcg ggg cgg ggt gca ggc tgg agc ctt cgg     647
      Met Ala Ala Pro Arg Ala Gly Arg Gly Ala Gly Trp Ser Leu Arg
        1               5                  10                  15

 gca tgg cgg gct ttg ggg ggc att cgc tgg ggg agg aga ccc cgt ttg      695
 Ala Trp Arg Ala Leu Gly Gly Ile Arg Trp Gly Arg Arg Pro Arg Leu
                  20                  25                  30

 acc cct gac ctc cgg gcc ctg ctg acg tca gga act tct gac ccc cgg      743
 Thr Pro Asp Leu Arg Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg
              35                  40                  45

 gcc cga gtg act tat ggg acc ccc agt ctc tgg gcc cgg ttg tct gtt      791
 Ala Arg Val Thr Tyr Gly Thr Pro Ser Leu Trp Ala Arg Leu Ser Val
          50                  55                  60

 ggg gtc act gaa ccc cga gca tgc ctg acg tct ggg acc ccg ggt ccc      839
 Gly Val Thr Glu Pro Arg Ala Cys Leu Thr Ser Gly Thr Pro Gly Pro
      65                  70                  75

 cgg gca caa ctg act gcg gtg acc cca gat acc agg acc cgg gag gcc      887
 Arg Ala Gln Leu Thr Ala Val Thr Pro Asp Thr Arg Thr Arg Glu Ala
  80                  85                  90                  95

 tca gag aac tct gga acc cgt tcg cgc gcg tgg ctg gcg gtg gcg ctg      935
 Ser Glu Asn Ser Gly Thr Arg Ser Arg Ala Trp Leu Ala Val Ala Leu
                 100                 105                 110

 ggc gct ggg ggg gca gtg ctg ttg ttg ttg tgg ggc ggg ggt cgg ggt      983
 Gly Ala Gly Gly Ala Val Leu Leu Leu Leu Trp Gly Gly Gly Arg Gly
             115                 120                 125

 cct ccg gcc gtc ctc gcc gcc gtc cct agc ccg ccg ccc gct tct ccc     1031
 Pro Pro Ala Val Leu Ala Ala Val Pro Ser Pro Pro Pro Ala Ser Pro
         130                 135                 140

 cgg agt cag tac aac ttc atc gca gat gtg gtg gag aag aca gca cct     1079
 Arg Ser Gln Tyr Asn Phe Ile Ala Asp Val Val Glu Lys Thr Ala Pro
     145                 150                 155

 gcc gtg gtc tat atc gag atc ctg gac cgg cac cct ttc ttg ggc cgc     1127
 Ala Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Phe Leu Gly Arg
 160                 165                 170                 175

 gag gtc cct atc tcg aac ggc tca gga ttc gtg gtg gct gcc gat ggg     1175
 Glu Val Pro Ile Ser Asn Gly Ser Gly Phe Val Val Ala Ala Asp Gly
                 180                 185                 190

 ctc att gtc acc aac gcc cat gtg gtg gct gat cgg cgc aga gtc cgt     1223
 Leu Ile Val Thr Asn Ala His Val Val Ala Asp Arg Arg Arg Val Arg
             195                 200                 205

 gtg aga ctg cta agc ggc gac acg tat gag gcc gtg gtc aca gct gtg     1271
 Val Arg Leu Leu Ser Gly Asp Thr Tyr Glu Ala Val Val Thr Ala Val
         210                 215                 220

 gat ccc gtg gca gac atc gca acg ctg agg att cag act aag gag cct     1319
 Asp Pro Val Ala Asp Ile Ala Thr Leu Arg Ile Gln Thr Lys Glu Pro
     225                 230                 235

 ctc ccc acg ctg cct ctg gga cgc tca gct gat gtc cgg caa ggg gag     1367
 Leu Pro Thr Leu Pro Leu Gly Arg Ser Ala Asp Val Arg Gln Gly Glu
 240                 245                 250                 255

 ttt gtt gtt gcc atg gga agt ccc ttt gca ctg cag aac acg atc aca     1415
 Phe Val Val Ala Met Gly Ser Pro Phe Ala Leu Gln Asn Thr Ile Thr
                 260                 265                 270

 tcc ggc att gtt agc tct gct cag cgt cca gcc aga gac ctg gga ctc     1463
 Ser Gly Ile Val Ser Ser Ala Gln Arg Pro Ala Arg Asp Leu Gly Leu
             275                 280                 285

 ccc caa acc aat gtg gaa tac att caa act gat gca gct att gat ttt     1511
 Pro Gln Thr Asn Val Glu Tyr Ile Gln Thr Asp Ala Ala Ile Asp Phe
         290                 295                 300

 gga aac tct gga ggt ccc ctg gtt aac ctg gat ggg gag gtg att gga     1559
 Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly
     305                 310                 315

 gtg aac acc atg aag gtc aca gct gga atc tcc ttt gcc atc cct tct     1607
 Val Asn Thr Met Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser
 320                 325                 330                 335

 gat cgt ctt cga gag ttt ctg cat cgt ggg gaa aag aag aat tcc tcc     1655
 Asp Arg Leu Arg Glu Phe Leu His Arg Gly Glu Lys Lys Asn Ser Ser
                 340                 345                 350

 tcc gga atc agt ggg tcc cag cgg cgc tac att ggg gtg atg atg ctg     1703
 Ser Gly Ile Ser Gly Ser Gln Arg Arg Tyr Ile Gly Val Met Met Leu
             355                 360                 365

 acc ctg agt ccc agg gct ggt ctg cgg cct ggt gat gtg att ttg gcc     1751
 Thr Leu Ser Pro Arg Ala Gly Leu Arg Pro Gly Asp Val Ile Leu Ala
         370                 375                 380

 att ggg gag cag atg gta caa aat gct gaa gat gtt tat gaa gct gtt     1799
 Ile Gly Glu Gln Met Val Gln Asn Ala Glu Asp Val Tyr Glu Ala Val
     385                 390                 395

 cga acc caa tcc cag ttg gca gtg cag atc cgg cgg gga cga gaa aca     1847
 Arg Thr Gln Ser Gln Leu Ala Val Gln Ile Arg Arg Gly Arg Glu Thr
 400                 405                 410                 415

 ctg acc tta tat gtg acc cct gag gtc aca gaa tga atag atcaccaaga     1897
 Leu Thr Leu Tyr Val Thr Pro Glu Val Thr Glu 
                 420                 425

 gtatgaggct cctgctctga tttcctcctt gcctttctgg ctgaggttct gagggcaccg   1957

 agacagaggg ttaaatgaac cagtgggggc aggtccctcc aaccaccagc actgactcct   2017

 gggctctgaa gaatcacaga aacacttttt atataaaata aaattatacc tagcaacaaa   2077

 aaaaaaaaaa aaa                                                      2090




      <210> 511
      <211> 762
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (222)..(743)

      <400> 511
 cagtccatat agagctgtcc tacagcattc tggaaacttg aggatgtgcg gtgcataaag     60

 gggctggaag tgacccacct gtgatgagcc ctttctaagg agaagggttt ccaagagatc    120

 accccaccag aaaaggatac aagagggtca ccactcacag aagaatatgg ctggccctgg    180

 gcctttgctg gctggtgtca ttcctggtgg gattgacccc c    atg ttt ggc tgg     233
                                                  Met Phe Gly Trp
                                                    1

 aac atg aaa ctg acc tca gag tac cac aga aat gtc acc ttc ctt tca      281
 Asn Met Lys Leu Thr Ser Glu Tyr His Arg Asn Val Thr Phe Leu Ser
   5                  10                  15                  20

 tgc caa ttt gtt tcc gtc atg aga atg gac tac atg gta tac ttc agc      329
 Cys Gln Phe Val Ser Val Met Arg Met Asp Tyr Met Val Tyr Phe Ser
                  25                  30                  35

 ttc ctc acc tgg att ttc atc ccc ctg gtt gtc atg tgc gcc atc tat      377
 Phe Leu Thr Trp Ile Phe Ile Pro Leu Val Val Met Cys Ala Ile Tyr
              40                  45                  50

 ctt gac atc ttt tac atc att cgg aac aaa ctc agt ctg aac tta tct      425
 Leu Asp Ile Phe Tyr Ile Ile Arg Asn Lys Leu Ser Leu Asn Leu Ser
          55                  60                  65

 aac tcc aaa gag aca ggt gca ttt tat gga cgg gag ttc aag acg gct      473
 Asn Ser Lys Glu Thr Gly Ala Phe Tyr Gly Arg Glu Phe Lys Thr Ala
      70                  75                  80

 aag tcc ttg ttt ctg gtt ctt ttc ttg ttt gct ctg tca tgg ctg cct      521
 Lys Ser Leu Phe Leu Val Leu Phe Leu Phe Ala Leu Ser Trp Leu Pro
  85                  90                  95                 100

 tta tct atc atc aac tgc atc atc tac ttt aat ggt gag gta cca cag      569
 Leu Ser Ile Ile Asn Cys Ile Ile Tyr Phe Asn Gly Glu Val Pro Gln
                 105                 110                 115

 ctt gtg ctg tac atg ggc atc ctg ctg tcc cat gcc aac tcc atg atg      617
 Leu Val Leu Tyr Met Gly Ile Leu Leu Ser His Ala Asn Ser Met Met
             120                 125                 130

 aac cct atc gtc tat gcc tat aaa ata aag aag ttc aag gaa acc tac      665
 Asn Pro Ile Val Tyr Ala Tyr Lys Ile Lys Lys Phe Lys Glu Thr Tyr
         135                 140                 145

 ctt ttg atc ctc aaa gcc tgt gtg gtc tgc cat ccc tct gat tct ttg      713
 Leu Leu Ile Leu Lys Ala Cys Val Val Cys His Pro Ser Asp Ser Leu
     150                 155                 160

 gac aca agc att gag aag aat tct gag tag ttatccatca gagatgact         762
 Asp Thr Ser Ile Glu Lys Asn Ser Glu 
 165                 170





      <210> 512
      <211> 2336
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (185)..(1060)

      <400> 512
 tgtataggcc cctcaaacgt cccgccagtg gaccgccagt gtcatgaata tccgcagaaa     60

 tcgcccttct aatacgactc gctatagggc cagcactgat aacaccgcag agtatgcggg    120

 gcggcagctg agcagaggcg gcggcgcggg acctgcagtc gccagggatt ccctccaggt    180

 gacg atg ctc tgg ttc tcc ggc gtc ggg gct ctg gct gag cgt tac tgc     229
      Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys
        1               5                  10                  15

 cgc cgc tcg cct ggg att acg tgc tgc gtc ttg ctg cta ctc aat tgc      277
 Arg Arg Ser Pro Gly Ile Thr Cys Cys Val Leu Leu Leu Leu Asn Cys
                  20                  25                  30

 tcg ggg gtc ccc atg tct ctg gct tcc tcc ttc ttg aca ggt tct gtt      325
 Ser Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Thr Gly Ser Val
              35                  40                  45

 gca aaa tgt gaa aat gaa ggt gaa gtc ctc cag att cca ttt atc aca      373
 Ala Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Thr
          50                  55                  60

 gac aac cct tgc ata atg tgt gtc tgc ttg aac aag gaa gtg aca tgt      421
 Asp Asn Pro Cys Ile Met Cys Val Cys Leu Asn Lys Glu Val Thr Cys
      65                  70                  75

 aag aga gag aag tgc ccc gtg ctg tcc cga gac tgt gcc ctg gcc atc      469
 Lys Arg Glu Lys Cys Pro Val Leu Ser Arg Asp Cys Ala Leu Ala Ile
  80                  85                  90                  95

 aag cag agg gga gcc tgt tgt gaa cag tgc aaa ggt tgc acc tat gaa      517
 Lys Gln Arg Gly Ala Cys Cys Glu Gln Cys Lys Gly Cys Thr Tyr Glu
                 100                 105                 110

 gga aat acc tat aac agc tcc ttc aaa tgg cag agc ccg gct gag cct      565
 Gly Asn Thr Tyr Asn Ser Ser Phe Lys Trp Gln Ser Pro Ala Glu Pro
             115                 120                 125

 tgt gtt cta cgc cag tgc cag gag ggt gtt gtc aca gag tct ggg gtg      613
 Cys Val Leu Arg Gln Cys Gln Glu Gly Val Val Thr Glu Ser Gly Val
         130                 135                 140

 cgc tgt gtt gtt cat tgt aaa aac cct ttg gag cat ctg gga atg tgc      661
 Arg Cys Val Val His Cys Lys Asn Pro Leu Glu His Leu Gly Met Cys
     145                 150                 155

 tgc ccc aca tgt cca ggc tgt gtg ttt gag ggt gtg cag tat caa gaa      709
 Cys Pro Thr Cys Pro Gly Cys Val Phe Glu Gly Val Gln Tyr Gln Glu
 160                 165                 170                 175

 ggg gag gaa ttt cag cca gaa gga agc aaa tgt acc aag tgt tcc tgc      757
 Gly Glu Glu Phe Gln Pro Glu Gly Ser Lys Cys Thr Lys Cys Ser Cys
                 180                 185                 190

 act gtc aga gga aag tgt ttg acc tcc ctt ttg gga gct gcc tct ttc      805
 Thr Val Arg Gly Lys Cys Leu Thr Ser Leu Leu Gly Ala Ala Ser Phe
             195                 200                 205

 gaa gtg atg ttt atg aca atg gat cct cat ttc tgt acg ata act gca      853
 Glu Val Met Phe Met Thr Met Asp Pro His Phe Cys Thr Ile Thr Ala
         210                 215                 220

 cag ctt gta cct gca ggg act cta ctg tgg ttt gca aga gga agt gct      901
 Gln Leu Val Pro Ala Gly Thr Leu Leu Trp Phe Ala Arg Gly Ser Ala
     225                 230                 235

 ccc acc ctg gtg gct gtg acc aag gcc agg agg gct gtt gtg aag agt      949
 Pro Thr Leu Val Ala Val Thr Lys Ala Arg Arg Ala Val Val Lys Ser
 240                 245                 250                 255

 gcc tcc tac gag tgc ccc cag aag aca tca aag tat gca aat ttg gca      997
 Ala Ser Tyr Glu Cys Pro Gln Lys Thr Ser Lys Tyr Ala Asn Leu Ala
                 260                 265                 270

 aca aga ttt tcc agg atg gag aga tgt ggt cct cta tca att gta cca     1045
 Thr Arg Phe Ser Arg Met Glu Arg Cys Gly Pro Leu Ser Ile Val Pro
             275                 280                 285

 tct gtg ctt gtg tga aaggcaggac ggagtgtcgc aataagcagt gcattcccat     1100
 Ser Val Leu Val 
         290

 cagtagctgc ccacagggca aaattctcaa cagaaaagga tgctgtccta tttgcactga   1160

 aaagcccggc gtttgcacgg tgtttggaga tccccactac aacacttttg acggtcggac   1220

 atttaacttt caggggacgt gtcagtacgt tttgacaaaa gactgctcct cccctgcctc   1280

 gcccttccag gtgctggtga agaacgacgc ccgccggaca cgctccttct cgtggaccaa   1340

 gtcggtggag ctggtgctgg gcgagagcag ggtcagcctg cagcagcacc tcaccgtgcg   1400

 ctggaacggc tcgcgcatcg cgctcccctg ccgcgcgcca cacttccaca tcgacctgga   1460

 tggctacctc ttgaaagtga ccaccaaagc aggtttggaa atatcttggg atggagacag   1520

 ttttgtagaa gtcatggctg cgccgcatct caagggcaag ctctgtggtc tttgtggcaa   1580

 ctacaatgga cataaacgtg atgacttaat tggtggagat ggaaacttca agtttgatgt   1640

 ggatgacttt gctgaatctt ggagggtgga gtccaatgag ttctgcaaca gacctcagag   1700

 aaagccagtg cctgaactgt gtcaagggac agtcaaggta aagctccggg cccatcgaga   1760

 atgccaaaag ctcaaatcct gggagtttca gacctgccac tcgactgtgg actacgccac   1820

 tttctaccgg tcctgtgtga cagacatgtg tgaatgtcca gtccataaaa actgttattg   1880

 cgagtcattt ttggcatata cccgggcctg ccagagagag ggcatcaaag tccactggga   1940

 gcctcagcag aattgtgcag ccacccagtg taagcatggt gctgtgtacg atacctgtgg   2000

 tccgggatgt atcaagacct gtgacaactg gaatgaaatt ggtccatgca acaagccgtg   2060

 cgttgctggg tgccactgtc cagcaaactt ggtccttcac aagggaaggt gcatcaagcc   2120

 agtcctttgt ccccagcggt gacctttgtt tcgatcctta agactctgaa atctggtgac   2180

 tttgacactg aagcggaaga gccaatgaag ggctgcagta tttgtgtgcc cgattctgta   2240

 aacacacaca cacagagtat atatgtgtat atatatatag atatattcaa aaacattcat   2300

 catttattta tgaactatag gctcagaaca acgaca                             2336




      <210> 513
      <211> 966
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(966)

      <400> 513
  atg gaa aca atc acc tgt aat gga tca ggg gac tcc tca acc acc ttc      48
  Met Glu Thr Ile Thr Cys Asn Gly Ser Gly Asp Ser Ser Thr Thr Phe
    1               5                  10                  15

 tac ctt atg ggc atc ccc tct ctg cca aaa tcc ctt ttc ctt cct att       96
 Tyr Leu Met Gly Ile Pro Ser Leu Pro Lys Ser Leu Phe Leu Pro Ile
              20                  25                  30

 ttc ttt gtc ttt ctc ctc ctc tac gtg ctc atc ctg atg ggt aat acc      144
 Phe Phe Val Phe Leu Leu Leu Tyr Val Leu Ile Leu Met Gly Asn Thr
          35                  40                  45

 ttt atc ctg gtg gct gtg gtg gcc aag ccc agc ctc cac aag ccc atg      192
 Phe Ile Leu Val Ala Val Val Ala Lys Pro Ser Leu His Lys Pro Met
      50                  55                  60

 tac ttc ttc ctg ata aac ctc tcc acc ttg gac att ctt gtt acc aca      240
 Tyr Phe Phe Leu Ile Asn Leu Ser Thr Leu Asp Ile Leu Val Thr Thr
  65                  70                  75                  80

 acc act gtc ccc aag atg ctg tcc ctg ttc ttg ttt ggg gac agc ttc      288
 Thr Thr Val Pro Lys Met Leu Ser Leu Phe Leu Phe Gly Asp Ser Phe
                  85                  90                  95

 ctc agc ttc cct gcc tgc ttc ctg cag atg tac ctg ttc cac agc ttc      336
 Leu Ser Phe Pro Ala Cys Phe Leu Gln Met Tyr Leu Phe His Ser Phe
             100                 105                 110

 tcc tgc tca gaa gcc ttc atc ctg gtg gtc atg gcc tat gac cgc tat      384
 Ser Cys Ser Glu Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg Tyr
         115                 120                 125

 gtg gct atc tgc cgc cca ctg cac tac cct gtc ctc atg acc cct cag      432
 Val Ala Ile Cys Arg Pro Leu His Tyr Pro Val Leu Met Thr Pro Gln
     130                 135                 140

 acc aac act gtc ttg aca acc agt gcc tgg ctc act gcc ctc ctc ctg      480
 Thr Asn Thr Val Leu Thr Thr Ser Ala Trp Leu Thr Ala Leu Leu Leu
 145                 150                 155                 160

 ccc att cca gca gtg gta cag acc tcc cag atg gca ttt gac atc att      528
 Pro Ile Pro Ala Val Val Gln Thr Ser Gln Met Ala Phe Asp Ile Ile
                 165                 170                 175

 gtc cac atc tac cac tgc ttc tgt gac cac ctg gct gtg gtc cag gcc      576
 Val His Ile Tyr His Cys Phe Cys Asp His Leu Ala Val Val Gln Ala
             180                 185                 190

 tcc tgc tct gac acc agc ccc cag acc ttc atg ggc ttc tgc atc gcc      624
 Ser Cys Ser Asp Thr Ser Pro Gln Thr Phe Met Gly Phe Cys Ile Ala
         195                 200                 205

 atg gtg gtg tcc ttc ctc ccc ctt ctg ctg gtg ctt ctc tcc tat gcc      672
 Met Val Val Ser Phe Leu Pro Leu Leu Leu Val Leu Leu Ser Tyr Ala
     210                 215                 220

 cac atc ttg acc tca gtg ctt tgc atc aac tgc caa gaa gga cgc tcc      720
 His Ile Leu Thr Ser Val Leu Cys Ile Asn Cys Gln Glu Gly Arg Ser
 225                 230                 235                 240

 aaa gcc ttc tcc acc tgc agc tcc cac ctc ctg gtg gtg ggc acc tac      768
 Lys Ala Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Gly Thr Tyr
                 245                 250                 255

 tat tca tcc att gcc ata gcc tat gtg gcc tac agg gct gac ctg ccc      816
 Tyr Ser Ser Ile Ala Ile Ala Tyr Val Ala Tyr Arg Ala Asp Leu Pro
             260                 265                 270

 cta gac ttc cac gtc atg ggc aat gtg gta tat gcc att ctc aca cct      864
 Leu Asp Phe His Val Met Gly Asn Val Val Tyr Ala Ile Leu Thr Pro
         275                 280                 285

 gtt ctc aac cct gtc atc tac aaa ctg agg aac aag gat gtc aaa gca      912
 Val Leu Asn Pro Val Ile Tyr Lys Leu Arg Asn Lys Asp Val Lys Ala
     290                 295                 300

 gcc atc acc aag att gca tgt ccc cag gag cca aag aat gct agg aaa      960
 Ala Ile Thr Lys Ile Ala Cys Pro Gln Glu Pro Lys Asn Ala Arg Lys
 305                 310                 315                 320

 ccc tga                                                              966
 Pro 






      <210> 514
      <211> 1198
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (608)..(1066)

      <400> 514
 agagatcggc ttcacgttcg gggaacagtg gaaatgaaac gcacaccatt ctaccgcagg     60

 cccgggcgag ccgggcaatt ctccggcctc cgtgaacgcg ttatctggat gattcagacg    120

 cgcggccgcc cggtcactgg cagcgaaatc gccgagaagt ttggcgtatc gctcattgag    180

 tttaaccggg tcgccaacgg catcacccgc ggcaccggac agatagcgca gatcgttgag    240

 tcggaaaaat ggatcaacga ggacggcatc tgcgaccgga cattcgacct ggttacgaag    300

 ccaaaggtca ttacgccgca gggtaaatct cggctgttca cccggcgcgc catagagcag    360

 tcgcaggaag gcaggcggca ggagtgcatt gaacgtgcag cacgccgtcg ccgcctgatt    420

 gctcagggcc tctatatcga cgaaatggag tccatcctat gactcacgct cacgacgaca    480

 tcagcgtagg cacactgtgc ctccccttca ttggtaactg ctggctaata ccatggggtg    540

 aagtggtcag caatccatta aaggcgcagc ggctcgctga ggaatatcgg gaaaggcagg    600

 aggcagc  atg aga tac gga tct gtt tgc agt gga gct gcg gcg atg ccc     649
          Met Arg Tyr Gly Ser Val Cys Ser Gly Ala Ala Ala Met Pro
            1               5                  10

 ata gaa gaa ccg gcg ctg cgc agc tgg cag cgc ccg ttc ctt aaa tgg      697
 Ile Glu Glu Pro Ala Leu Arg Ser Trp Gln Arg Pro Phe Leu Lys Trp
  15                  20                  25                  30

 gct ggc ggc aaa tat tcg ctg ctg ccg gaa ctg gat cgt ttg atc ccc      745
 Ala Gly Gly Lys Tyr Ser Leu Leu Pro Glu Leu Asp Arg Leu Ile Pro
                  35                  40                  45

 gca ggt aaa cgc ctt att gag cct ttt gtg ggt ggc ggc tcg gtg ttc      793
 Ala Gly Lys Arg Leu Ile Glu Pro Phe Val Gly Gly Gly Ser Val Phe
              50                  55                  60

 ctt aac tca gac aag cac gaa cgc ttc ctt ctg gct gac gtc agc gct      841
 Leu Asn Ser Asp Lys His Glu Arg Phe Leu Leu Ala Asp Val Ser Ala
          65                  70                  75

 gac ctg att aac ctg tat cag atg ctg gcg gtg gtc ccc gat tcg gtg      889
 Asp Leu Ile Asn Leu Tyr Gln Met Leu Ala Val Val Pro Asp Ser Val
      80                  85                  90

 atc tat gag gca atg aag gca ttc agg cat ctt aat gat gcc gaa aac      937
 Ile Tyr Glu Ala Met Lys Ala Phe Arg His Leu Asn Asp Ala Glu Asn
  95                 100                 105                 110

 tat acg tta att cgt gaa gca ttc aac gcg cag cgg ctg gat gcg gtc      985
 Tyr Thr Leu Ile Arg Glu Ala Phe Asn Ala Gln Arg Leu Asp Ala Val
                 115                 120                 125

 gag cgt gca gca gca ttc ctt tac ctc aat cgg cac tgc ttc aac ggc     1033
 Glu Arg Ala Ala Ala Phe Leu Tyr Leu Asn Arg His Cys Phe Asn Gly
             130                 135                 140

 ctg att cgt tac aac ctg gac ggt ttt ttt taa cgtcggct ttgggaaata     1084
 Leu Ile Arg Tyr Asn Leu Asp Gly Phe Phe 
         145                 150

 taaagcgcca tatttcccgg aagaagagat caaggcattt aagcggaagg ctcacgcatg   1144

 cgtattcatg aatgcaggct tcaggcgcac gctcgcgctg gcaggtgatg gtga         1198




      <210> 515
      <211> 555
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(555)

      <400> 515
  atg atg tca ttc ctg ctc ggc gca atc ctg acc ctg ctc tgg gcg ccc      48
  Met Met Ser Phe Leu Leu Gly Ala Ile Leu Thr Leu Leu Trp Ala Pro
    1               5                  10                  15

 acg gct cag gct gag gtt ctg ctg cag cct gac ttc aat gct gaa aag       96
 Thr Ala Gln Ala Glu Val Leu Leu Gln Pro Asp Phe Asn Ala Glu Lys
              20                  25                  30

 ttc tca ggc ctc tgg tac gtg gtc tcc atg gca tct gac tgc agg gtc      144
 Phe Ser Gly Leu Trp Tyr Val Val Ser Met Ala Ser Asp Cys Arg Val
          35                  40                  45

 ttc ctg ggc aag aag gac cac ctg tcc atg tcc acc agg gcc atc agg      192
 Phe Leu Gly Lys Lys Asp His Leu Ser Met Ser Thr Arg Ala Ile Arg
      50                  55                  60

 ccc aca gag gag ggc ggc ctc cac gtc cac atg gag ttc ccg ggg gcg      240
 Pro Thr Glu Glu Gly Gly Leu His Val His Met Glu Phe Pro Gly Ala
  65                  70                  75                  80

 gac ggc tgt aac cag gtg gat gcc gag tac ctg aag gtg ggc tcc gag      288
 Asp Gly Cys Asn Gln Val Asp Ala Glu Tyr Leu Lys Val Gly Ser Glu
                  85                  90                  95

 gga cac ttc aga gtc ccg gcc ttg ggc tac ctg gac gtg cgc atc gtg      336
 Gly His Phe Arg Val Pro Ala Leu Gly Tyr Leu Asp Val Arg Ile Val
             100                 105                 110

 gac aca gac tac agc tcc ttc gcc gtc ctt tac atc tac aag gag ctg      384
 Asp Thr Asp Tyr Ser Ser Phe Ala Val Leu Tyr Ile Tyr Lys Glu Leu
         115                 120                 125

 gag ggg gcc ctc agc acc atg gtg cag ctc tac agc cgg acc cag gat      432
 Glu Gly Ala Leu Ser Thr Met Val Gln Leu Tyr Ser Arg Thr Gln Asp
     130                 135                 140

 gtg agt ccc cag gct ctg aag gcc ttc cag gac ttc tac ccg acc ctg      480
 Val Ser Pro Gln Ala Leu Lys Ala Phe Gln Asp Phe Tyr Pro Thr Leu
 145                 150                 155                 160

 ggg ctc ccc gag gac atg atg gtc atg ctg ccc cag tca gat gca tgc      528
 Gly Leu Pro Glu Asp Met Met Val Met Leu Pro Gln Ser Asp Ala Cys
                 165                 170                 175

 aac cct gag agc aag gag gcg ccc tga                                  555
 Asn Pro Glu Ser Lys Glu Ala Pro 
             180





      <210> 516
      <211> 2492
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (346)..(1779)

      <400> 516
 agcggcgagg agtggttgcg cgtgttgcgg cccgggttct gttcgtaggt ttacaattgt     60

 cgcgggtagt ggggcgcccc agctgccaac tgcacgtggt ttctttctgg cgtttgccta    120

 gtgtcctgtc cattccgccc cgttgggaag tgggaagcgg agaggttctg tggggacaga    180

 gctgggagtc ctgaaggaga aagcgcgcag ccgaggggct ctggagtgcc ttagagcaga    240

 gctgcggccg cggaagggga gcagctgaga aaggagggcc gctgcaggcg gggttcgaac    300

 cgtggggtct gggctgctcc cgcggagggc ctgggcggac gcggg    atg ctg ggg     354
                                                      Met Leu Gly
                                                        1

 gtc cgc tgc ctg ctg cgg tcc gtg cgc ttc tgt tcc tcc gcc ccc ttc      402
 Val Arg Cys Leu Leu Arg Ser Val Arg Phe Cys Ser Ser Ala Pro Phe
       5                  10                  15

 ccc aag cac aaa cct tca gcc aaa ctg agc gtg cgg gac gct ctc ggg      450
 Pro Lys His Lys Pro Ser Ala Lys Leu Ser Val Arg Asp Ala Leu Gly
  20                  25                  30                  35

 gct cag aac gcg agt ggg gag cgc att aag atc cag gga tgg att cgt      498
 Ala Gln Asn Ala Ser Gly Glu Arg Ile Lys Ile Gln Gly Trp Ile Arg
                  40                  45                  50

 tct gtc cga tcc cag aag gaa gtc ttg ttc ctg cat gta aat gat ggg      546
 Ser Val Arg Ser Gln Lys Glu Val Leu Phe Leu His Val Asn Asp Gly
              55                  60                  65

 tca tct ttg gaa agc ctt cag gtt gtt gca gat tca ggc ctt gac agt      594
 Ser Ser Leu Glu Ser Leu Gln Val Val Ala Asp Ser Gly Leu Asp Ser
          70                  75                  80

 aga gaa tta act ttt ggg agt tct gtg gaa gta caa ggg cag ctg ata      642
 Arg Glu Leu Thr Phe Gly Ser Ser Val Glu Val Gln Gly Gln Leu Ile
      85                  90                  95

 aaa agt cca tcc aaa agg caa aat gtg gaa ctg aag gca gaa aaa att      690
 Lys Ser Pro Ser Lys Arg Gln Asn Val Glu Leu Lys Ala Glu Lys Ile
 100                 105                 110                 115

 aaa gtt att gga aat tgt gat gcc aag gat ttc ccc atc aaa tat aaa      738
 Lys Val Ile Gly Asn Cys Asp Ala Lys Asp Phe Pro Ile Lys Tyr Lys
                 120                 125                 130

 gag agg cat cct ctg gag tac ctg cga caa tat cct cac ttt agg tgt      786
 Glu Arg His Pro Leu Glu Tyr Leu Arg Gln Tyr Pro His Phe Arg Cys
             135                 140                 145

 agg act aac gtt ctg ggt tct ata ttg agg att cgc agt gaa gcg aca      834
 Arg Thr Asn Val Leu Gly Ser Ile Leu Arg Ile Arg Ser Glu Ala Thr
         150                 155                 160

 gct gct att cat tct ttc ttt aag gac agt ggc ttt gta cat att cat      882
 Ala Ala Ile His Ser Phe Phe Lys Asp Ser Gly Phe Val His Ile His
     165                 170                 175

 act cca ata atc aca tcc aat gac tct gag gga gct gga gaa ctt ttt      930
 Thr Pro Ile Ile Thr Ser Asn Asp Ser Glu Gly Ala Gly Glu Leu Phe
 180                 185                 190                 195

 caa ctt gaa cct tca ggc aaa ctt aag gta cct gag gag aat ttc ttc      978
 Gln Leu Glu Pro Ser Gly Lys Leu Lys Val Pro Glu Glu Asn Phe Phe
                 200                 205                 210

 aat gtt cct gct ttc tta act gtc tca gga caa ctt cat cta gaa gtg     1026
 Asn Val Pro Ala Phe Leu Thr Val Ser Gly Gln Leu His Leu Glu Val
             215                 220                 225

 atg tca gga gct ttt act caa gtg ttt acc ttt ggt ccg acc ttc cga     1074
 Met Ser Gly Ala Phe Thr Gln Val Phe Thr Phe Gly Pro Thr Phe Arg
         230                 235                 240

 gct gaa aat tct cag agc cgg agg cac ctg gca gag ttt tat atg ata     1122
 Ala Glu Asn Ser Gln Ser Arg Arg His Leu Ala Glu Phe Tyr Met Ile
     245                 250                 255

 gaa gca gag att tct ttt gtt gac agc ctt caa gat ctt atg cag gtt     1170
 Glu Ala Glu Ile Ser Phe Val Asp Ser Leu Gln Asp Leu Met Gln Val
 260                 265                 270                 275

 ata gag gaa ctg ttc aag gct aca aca atg atg gtt ctc tca aaa tgt     1218
 Ile Glu Glu Leu Phe Lys Ala Thr Thr Met Met Val Leu Ser Lys Cys
                 280                 285                 290

 cct gaa gat gtt gaa ctc tgt cac aaa ttc ata gca cct ggc caa aag     1266
 Pro Glu Asp Val Glu Leu Cys His Lys Phe Ile Ala Pro Gly Gln Lys
             295                 300                 305

 gac aga tta gaa cat atg cta aaa aac aac ttt tta atc att tct tat     1314
 Asp Arg Leu Glu His Met Leu Lys Asn Asn Phe Leu Ile Ile Ser Tyr
         310                 315                 320

 act gaa gca gtg gag atc tta aag caa gca tcc cag aac ttc acc ttt     1362
 Thr Glu Ala Val Glu Ile Leu Lys Gln Ala Ser Gln Asn Phe Thr Phe
     325                 330                 335

 acc cca gag tgg ggt gct gac cta cgg act gaa cat gaa aag tac ctg     1410
 Thr Pro Glu Trp Gly Ala Asp Leu Arg Thr Glu His Glu Lys Tyr Leu
 340                 345                 350                 355

 gtg aag cac tgt ggc aac ata cct gtc ttc gtt att aat tat cca tta     1458
 Val Lys His Cys Gly Asn Ile Pro Val Phe Val Ile Asn Tyr Pro Leu
                 360                 365                 370

 aca ctc aag cct ttc tac atg agg gat aat gaa gat ggc cct cag cac     1506
 Thr Leu Lys Pro Phe Tyr Met Arg Asp Asn Glu Asp Gly Pro Gln His
             375                 380                 385

 acg gtt gct gct gtt gat ctt ctg gtt cct gga gtt ggg gaa ctc ttt     1554
 Thr Val Ala Ala Val Asp Leu Leu Val Pro Gly Val Gly Glu Leu Phe
         390                 395                 400

 gga gga ggc ctc aga gaa gaa cga tac cat ttc tta gag gag cgc tta     1602
 Gly Gly Gly Leu Arg Glu Glu Arg Tyr His Phe Leu Glu Glu Arg Leu
     405                 410                 415

 gcc aga tcg gga ctt aca gaa gtc tac caa tgg tat ctg gac ctt cgt     1650
 Ala Arg Ser Gly Leu Thr Glu Val Tyr Gln Trp Tyr Leu Asp Leu Arg
 420                 425                 430                 435

 cga ttt gga tct gtg cca cat gga ggt ttt ggg atg gga ttt gaa cgc     1698
 Arg Phe Gly Ser Val Pro His Gly Gly Phe Gly Met Gly Phe Glu Arg
                 440                 445                 450

 tac ctg cag tgc atc ttg ggt gtt gac aat atc aaa gat gtt atc cct     1746
 Tyr Leu Gln Cys Ile Leu Gly Val Asp Asn Ile Lys Asp Val Ile Pro
             455                 460                 465

 ttc cca agg ttt cct cat tca tgc ctt tta tag ctggaaga ttggttaagg     1797
 Phe Pro Arg Phe Pro His Ser Cys Leu Leu 
         470                 475

 aaaagcaccc cccatggcag agacactgca catgattgtg catacagcag aatgcatgtt   1857

 tggattttag aaatgcagat ttcaatatgt aattgttgtg ccataagata tcatagaaaa   1917

 aatataagtg gttgtgattt tcttagaaag ttgagggtat ttcacgtaag gatgagctcc   1977

 cgcaagaaga ggtacttata gcaaggggac tctcaaatcc attacctcaa ttaagaaatg   2037

 aagaaattga attagtctca aagtttcttt taaactctaa aacagaatga gataatgtat   2097

 tttacgttgt ctataatcat taaatcactc cctgtgtaat ttgtgagaac catctagtag   2157

 ctcgaaataa aataatgttg catcttttct cccttgccat atactttgtg ataaatcctt   2217

 atctcatttt cagtacttca ttaaacattg cagaaaaaaa tattccttaa ggtcttaatt   2277

 gatttaaaga agtagctatt ctgaattgaa atctcctttc attgaactgg atgaaaaaat   2337

 catgtttaat aactgttgct tttcaatttt caaagctgtt gagatattac attaagtatt   2397

 tcaactcttt aatcactgtt gttataattt gtttatattt gatgtttata atttgtctaa   2457

 taaaatagat ttttttaata gaaaaaaaaa aaaaa                              2492




      <210> 517
      <211> 2977
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2100)

      <400> 517
  atg ctc aaa ctg tct gga gaa gga tta cgg gac agc tac cac agt aga      48
  Met Leu Lys Leu Ser Gly Glu Gly Leu Arg Asp Ser Tyr His Ser Arg
    1               5                  10                  15

 aga gat caa att gcc ctt aaa aat ctc cag tct gat gtc aca gag gcg       96
 Arg Asp Gln Ile Ala Leu Lys Asn Leu Gln Ser Asp Val Thr Glu Ala
              20                  25                  30

 aaa tct gac ttc acc aag gag acc ctg gca tca caa aac aca aaa atg      144
 Lys Ser Asp Phe Thr Lys Glu Thr Leu Ala Ser Gln Asn Thr Lys Met
          35                  40                  45

 att tca tcc ata gtc atc tcc cag atg att gat gag aat aag tca aga      192
 Ile Ser Ser Ile Val Ile Ser Gln Met Ile Asp Glu Asn Lys Ser Arg
      50                  55                  60

 gaa aac agg gcc tcc ttg ccc cta ccg tgt gcc att gct cag tct cgt      240
 Glu Asn Arg Ala Ser Leu Pro Leu Pro Cys Ala Ile Ala Gln Ser Arg
  65                  70                  75                  80

 gcg cat cac gcc aag caa tct ctg gct aac cgc agc gga gtc aac att      288
 Ala His His Ala Lys Gln Ser Leu Ala Asn Arg Ser Gly Val Asn Ile
                  85                  90                  95

 cac aga gca ttt gcg tta ctt ccg ggc aga tta gga atc ccg gca ccg      336
 His Arg Ala Phe Ala Leu Leu Pro Gly Arg Leu Gly Ile Pro Ala Pro
             100                 105                 110

 tca gat gag cga gga cct gag gca gag ctg ccg ccc aaa gag gag aga      384
 Ser Asp Glu Arg Gly Pro Glu Ala Glu Leu Pro Pro Lys Glu Glu Arg
         115                 120                 125

 ccc tgt ggg ggc ccc cgc aga ggg ttt gca tcc atc acc atc acg gcc      432
 Pro Cys Gly Gly Pro Arg Arg Gly Phe Ala Ser Ile Thr Ile Thr Ala
     130                 135                 140

 aga cgc gtg ggc ccc cca gcc cgc gcc ctg gtg tgg ggg act gct ggg      480
 Arg Arg Val Gly Pro Pro Ala Arg Ala Leu Val Trp Gly Thr Ala Gly
 145                 150                 155                 160

 gac tct ctg tgc ccc aag tgc agg gct gag gac aca ctg ttc cag gcg      528
 Asp Ser Leu Cys Pro Lys Cys Arg Ala Glu Asp Thr Leu Phe Gln Ala
                 165                 170                 175

 ccc ccg gct ctg gcc aat ggc gcc cat cca ggt cgg cat cag aga tct      576
 Pro Pro Ala Leu Ala Asn Gly Ala His Pro Gly Arg His Gln Arg Ser
             180                 185                 190

 ttt gcc tgc aca gag ttc tcc aga aac agc tcc gtg gtg cgg ctg aag      624
 Phe Ala Cys Thr Glu Phe Ser Arg Asn Ser Ser Val Val Arg Leu Lys
         195                 200                 205

 gtt ccc gag gcc cac act ggg ttg tgt gag aga cgc aag tac tgg gtc      672
 Val Pro Glu Ala His Thr Gly Leu Cys Glu Arg Arg Lys Tyr Trp Val
     210                 215                 220

 acc cat gca gac gac aaa gag acc agt ttt tct cca gac acc cca ctg      720
 Thr His Ala Asp Asp Lys Glu Thr Ser Phe Ser Pro Asp Thr Pro Leu
 225                 230                 235                 240

 tca gga aag agc ccg ctg gtg ttc agt tcc tgt gtc cac ctc agg gtg      768
 Ser Gly Lys Ser Pro Leu Val Phe Ser Ser Cys Val His Leu Arg Val
                 245                 250                 255

 tct cag cag tgt cca gat tca atc tat tac gta gac aag tct ctc tcc      816
 Ser Gln Gln Cys Pro Asp Ser Ile Tyr Tyr Val Asp Lys Ser Leu Ser
             260                 265                 270

 gtc ccc att gag cca cct caa att gcc agc ccc aaa atg cac aga tcc      864
 Val Pro Ile Glu Pro Pro Gln Ile Ala Ser Pro Lys Met His Arg Ser
         275                 280                 285

 gtc ctg tcg ctc aac ctc aat tgt agt tcc cac aga tta aca gca gat      912
 Val Leu Ser Leu Asn Leu Asn Cys Ser Ser His Arg Leu Thr Ala Asp
     290                 295                 300

 gga gta gat ggc cta gtg aac aga gag cca ata agc gaa gcc ctg aag      960
 Gly Val Asp Gly Leu Val Asn Arg Glu Pro Ile Ser Glu Ala Leu Lys
 305                 310                 315                 320

 cag gag ctc ctg gag gga gac cag gac ctc gta ggc cag cgc tgg aac     1008
 Gln Glu Leu Leu Glu Gly Asp Gln Asp Leu Val Gly Gln Arg Trp Asn
                 325                 330                 335

 cca ggt tta caa gaa agt cac ttg aag gaa acc cca tcg ttg agg cgg     1056
 Pro Gly Leu Gln Glu Ser His Leu Lys Glu Thr Pro Ser Leu Arg Arg
             340                 345                 350

 gtg cat ttg ggg acc ggc gct tgt cct tgg agt ggt tct ttt cca ttg     1104
 Val His Leu Gly Thr Gly Ala Cys Pro Trp Ser Gly Ser Phe Pro Leu
         355                 360                 365

 gaa aac aca gaa ttg gca aat gtg gga gct aac caa gtc act gta aga     1152
 Glu Asn Thr Glu Leu Ala Asn Val Gly Ala Asn Gln Val Thr Val Arg
     370                 375                 380

 aaa ggg gaa aag gac cat aca act cat tgt cac gcc agc gat cat gcc     1200
 Lys Gly Glu Lys Asp His Thr Thr His Cys His Ala Ser Asp His Ala
 385                 390                 395                 400

 aac caa ctg tcc att cac att cct ggc tgg agt tac agg gca gta cac     1248
 Asn Gln Leu Ser Ile His Ile Pro Gly Trp Ser Tyr Arg Ala Val His
                 405                 410                 415

 aca aaa gta ttt tct gga agc agc aag agg caa caa gga gaa gta tgt     1296
 Thr Lys Val Phe Ser Gly Ser Ser Lys Arg Gln Gln Gly Glu Val Cys
             420                 425                 430

 atg act gtg tct gct cct cca gtg gaa cag aag ccc act aga cat ttc     1344
 Met Thr Val Ser Ala Pro Pro Val Glu Gln Lys Pro Thr Arg His Phe
         435                 440                 445

 ctt ccc att ggg gat agc tct cca agc gat gac tgt ctg tct aga gac     1392
 Leu Pro Ile Gly Asp Ser Ser Pro Ser Asp Asp Cys Leu Ser Arg Asp
     450                 455                 460

 ctt tct gag ccc aca gag aga cga cat caa agc ttc ctg aaa ccc aga     1440
 Leu Ser Glu Pro Thr Glu Arg Arg His Gln Ser Phe Leu Lys Pro Arg
 465                 470                 475                 480

 atc ctt ttt cct ggg ttt ctt tgc ccc tta caa gat gta tgt gca tct     1488
 Ile Leu Phe Pro Gly Phe Leu Cys Pro Leu Gln Asp Val Cys Ala Ser
                 485                 490                 495

 ctg cag gaa gac aat ggt gtt cag ata gaa agc aag ttc ccc aaa gga     1536
 Leu Gln Glu Asp Asn Gly Val Gln Ile Glu Ser Lys Phe Pro Lys Gly
             500                 505                 510

 gat tac aca tgc tgt gac ttg gtt gta aaa ata aag gaa tgt aag aag     1584
 Asp Tyr Thr Cys Cys Asp Leu Val Val Lys Ile Lys Glu Cys Lys Lys
         515                 520                 525

 agt gag gac ccc acc aca cct gag ccc tcc cca gca gca ccc tcg cca     1632
 Ser Glu Asp Pro Thr Thr Pro Glu Pro Ser Pro Ala Ala Pro Ser Pro
     530                 535                 540

 gca ccc cgc gat gga gca ggg agc cct ggc ctg tcc gaa gac tgt tct     1680
 Ala Pro Arg Asp Gly Ala Gly Ser Pro Gly Leu Ser Glu Asp Cys Ser
 545                 550                 555                 560

 gag tct cag caa acg cct gca aga tct ttg acc ttg caa gaa gca ctg     1728
 Glu Ser Gln Gln Thr Pro Ala Arg Ser Leu Thr Leu Gln Glu Ala Leu
                 565                 570                 575

 gaa gtt cgt aag cct cag ttc att tct cgc tca caa gaa cgg ctg aag     1776
 Glu Val Arg Lys Pro Gln Phe Ile Ser Arg Ser Gln Glu Arg Leu Lys
             580                 585                 590

 aag ctt gaa cac atg gtc cag cag agg aaa gcc cag cgg aag gag gac     1824
 Lys Leu Glu His Met Val Gln Gln Arg Lys Ala Gln Arg Lys Glu Asp
         595                 600                 605

 ctg agg cag aag cag agc ctc ctt ccc atc cgc acc agc aag aag cag     1872
 Leu Arg Gln Lys Gln Ser Leu Leu Pro Ile Arg Thr Ser Lys Lys Gln
     610                 615                 620

 ttc acg att ccc cat cct ctg agt gat aac ttg ttc aaa ccc aaa gaa     1920
 Phe Thr Ile Pro His Pro Leu Ser Asp Asn Leu Phe Lys Pro Lys Glu
 625                 630                 635                 640

 cgg tgc att tca gag aag gag atg cat atg cga tct aag aga atc tat     1968
 Arg Cys Ile Ser Glu Lys Glu Met His Met Arg Ser Lys Arg Ile Tyr
                 645                 650                 655

 gat aac ttg ccg gaa gtt aaa aag aaa aaa gaa gaa caa aaa aaa agg     2016
 Asp Asn Leu Pro Glu Val Lys Lys Lys Lys Glu Glu Gln Lys Lys Arg
             660                 665                 670

 gtg atc tta caa agt aac aga ctc cgt gcc gaa gtc ttc aaa aag caa     2064
 Val Ile Leu Gln Ser Asn Arg Leu Arg Ala Glu Val Phe Lys Lys Gln
         675                 680                 685

 tta ctg gac cag ctc ctt caa agg aat gcg gtc taa ccac aggctgccct     2114
 Leu Leu Asp Gln Leu Leu Gln Arg Asn Ala Val 
     690                 695

 gctgaccaca ctacctggac ctgggaggac ttcgaatgct ggataagcca ttaaacttag   2174

 cattatcttc atcatgggaa aacacttatt ttactttcga tttttttttt ccataaagga   2234

 aaacatcact tcctgaatta ctgacccaag ccaaacagaa acaataaccc tcgagaaaat   2294

 aggtcaacaa tctgttgtgg ggaaaccacc tccatgtaac ccactggata cagtcccctt   2354

 aatgtttttg cttctaaatt gtaccttttg cttctgattt cttctcccct gctgtttcct   2414

 gcccatcaga gaggcctgat acaagcaagt ttgtttacat ccctggggaa tcttttacat   2474

 caaacttttg ggatccaaat ccatctcctt ttaaatttca atctcagcac ctgccagtta   2534

 tgcaaatgcc aaaatgtggg tcatcatata gtatatttga aacctttctg aacatgtaca   2594

 ccacccaatg ctagaggctg acttggaaac cggtgggtgc aatgcccgag gctgtggaac   2654

 aatcagccca tctctttgtg acctggagca gtcagagggc cctcagtcac cccgccccat   2714

 tcctcaccag agaaaagaat ccatttctat ggaagctctg acgtaacttc agtgttttct   2774

 acaatactcc tcctgccccg ccccattaaa acagttcttt tgttaagaaa tagcctaatg   2834

 gtccaacttt gctgtctgtt cttccaaatg tttataatac acattattta taaatatgtc   2894

 tgtttgggaa gctaagaaca agctagtttt tacaacacaa atggaaataa atgcaattat   2954

 tataaaaatt caaaaaaaaa aaa                                           2977




      <210> 518
      <211> 1960
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (109)..(594)

      <400> 518
 agatttttac taaggttgtt tagtgtagat tagctgtgaa tatcttgact cctttaaggt     60

 aataaggctt ttgttttttt ttatctttca cagctagaaa attatggc atg ccg ttt     117
                                                      Met Pro Phe
                                                        1

 agc aga act gaa gat ggg aag att tat cag cgt gca ttt ggt gga cag      165
 Ser Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala Phe Gly Gly Gln
       5                  10                  15

 agc ctc aag ttt gga aag ggc agg cag gcc cat cgg tgc tgc tgt gtg      213
 Ser Leu Lys Phe Gly Lys Gly Arg Gln Ala His Arg Cys Cys Cys Val
  20                  25                  30                  35

 gct gat cgg acc ggc cac tca ata ttg cac acc tca tat ggg agg tct      261
 Ala Asp Arg Thr Gly His Ser Ile Leu His Thr Ser Tyr Gly Arg Ser
                  40                  45                  50

 ctg aga tat gat acc agc tgt ttt gtg gag tat ttt gcc ttg gat ctc      309
 Leu Arg Tyr Asp Thr Ser Cys Phe Val Glu Tyr Phe Ala Leu Asp Leu
              55                  60                  65

 ctg ata gag aac agg gag tgc cgt ggt gtc att gca ctg tgc ata cag      357
 Leu Ile Glu Asn Arg Glu Cys Arg Gly Val Ile Ala Leu Cys Ile Gln
          70                  75                  80

 gac ggg tcc atc cat cgc ata aga gca aag aat act att gtt gcc aca      405
 Asp Gly Ser Ile His Arg Ile Arg Ala Lys Asn Thr Ile Val Ala Thr
      85                  90                  95

 ggg cta ctg gcg caa cta ctt gag ctg cac gtc tgc cca cac cag cac      453
 Gly Leu Leu Ala Gln Leu Leu Glu Leu His Val Cys Pro His Gln His
 100                 105                 110                 115

 cag cga cgg cac ggc cat gat cac cag ggc agg cct tcc ttg cca gga      501
 Gln Arg Arg His Gly His Asp His Gln Gly Arg Pro Ser Leu Pro Gly
                 120                 125                 130

 cct cga gtt tgt tca gtt cca ccc cac agg cac ata tgg tgc tgg ttg      549
 Pro Arg Val Cys Ser Val Pro Pro His Arg His Ile Trp Cys Trp Leu
             135                 140                 145

 tct cat tac gga agg atg tcg tgg aga ggg agg cat tct cat taa cag      597
 Ser His Tyr Gly Arg Met Ser Trp Arg Gly Arg His Ser His 
         150                 155                 160

 tcaaggcgaa aggtttatgg agcgatacgc ccccatcgcg aaggacctgg cgtctagaga    657

 tgtggtgtct cggtggatga ctctggagat ccgcgaagga agaggctgtg gccctgagaa    717

 agatcacgtc tacctgcagc tgcaccacct acctccagag cagctggcca tgcccttgcc    777

 cggcatttca gagacagcca tgatcttcgc tggtgtggac gtcacgaagg agccgatccc    837

 tgtcctcccc accgtgcatt ataacatgga cggcattccc accagctacg aggggcaggt    897

 cctgaggcac gggaatggcc aggatcagat tgtgcccagc ctgtacgcct gtggggaggc    957

 cgcctgtgcc tctgcacatg gtgtcaaccg cctcggggca aactcgctgt tggacctggt   1017

 tgtctggtca ggcatgtgcc ctgagcatcg cagagtcgtg caggcctgga gataaagtcc   1077

 ctccaattaa accaaatgct ggggaagaat ctgtcacgaa tgttgacaaa ttgagatttg   1137

 ctgatggaag aagcataaga acatcggaac tgcgactcag catgcagaag tcaacgcaaa   1197

 atcatgctgc cgtgttccgt gtgggaagct tgttgcaaga aggttgtggg aaaatcagca   1257

 agctctatgg agacctgaag catctgaaga cgtttgaccg gggaatggtc tggaacacgg   1317

 acctggtgga gaccctggag ctgcagaacc tgatgctatg tgcgctgcag accgtcaatg   1377

 gagcaaaggc ggggaaggag tcacggggcg cgcacgccgg ggaggctaac aagagcctgc   1437

 cctgtggtca cttgttcttc agatgaactg atttttgtgc agagcacacg tgttggattc   1497

 tgcctggtgc agattgatga gtacgattac tccaagccca tccaggggca acagaagaag   1557

 ccctttgagg agcactggag gaagcacacc ctgtcctatg tggacgttgg cactgggaag   1617

 acccgtaatc gacaaaactt tgaacgaggc tgactgtgcc accgtccccc cagccattcg   1677

 ctcctactga tgagacaaga tgcggtgatg acagaatcag cttttgtaat tatgtataat   1737

 agctcatgca tgtgtccatg tcataactgt cttcatacgc ttctgcactc cggggaagaa   1797

 ggagtacatt gaagggagat tggcacccag gctgggagct tgccaggaac ccagtggcca   1857

 gggagcgtgg cacttacctt tgtcccttgc ttcattcttg tgagatgata aaactgggca   1917

 cagctcttaa ataaaatata aatgaacaaa aaaaaaaaaa aag                     1960




      <210> 519
      <211> 3348
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (167)..(1612)

      <400> 519
 ggggcttgag ctctgcattt gggagagagg tccagggcca tgccaggtgt ctccctctcc     60

 ctgctgggca agggtcattt gaaggaccac gctctctttg ccccaggcct tgccggcccc    120

 aggaacgggg caggtgcagc tggttctggt ccgagggtcg gaaact   atg ccc cag     175
                                                      Met Pro Gln
                                                        1

 acg tcc gtt gtc ttc tcc agc atc ctt ggg ccc agc tgt agc gga cag      223
 Thr Ser Val Val Phe Ser Ser Ile Leu Gly Pro Ser Cys Ser Gly Gln
       5                  10                  15

 gtg cag cct ggc atg ggg gag cgt gga ggc ggg gcc ggt ggc ggc tcc      271
 Val Gln Pro Gly Met Gly Glu Arg Gly Gly Gly Ala Gly Gly Gly Ser
  20                  25                  30                  35

 ggg gac ctc atc ttc caa gat gga cac ctc atc tct ggg tcc ctg gag      319
 Gly Asp Leu Ile Phe Gln Asp Gly His Leu Ile Ser Gly Ser Leu Glu
                  40                  45                  50

 gcc ctg atg gag cac ctt gtt ccc acg gtg gac tat tac ccc gat agg      367
 Ala Leu Met Glu His Leu Val Pro Thr Val Asp Tyr Tyr Pro Asp Arg
              55                  60                  65

 acg tac atc ttc acc ttt ctc ctg agc tcc cgg gtc ttt atg ccc cct      415
 Thr Tyr Ile Phe Thr Phe Leu Leu Ser Ser Arg Val Phe Met Pro Pro
          70                  75                  80

 cat gac ctg ctg gcc cgc gtg ggg cag atc tgc gtg gag cag aag cag      463
 His Asp Leu Leu Ala Arg Val Gly Gln Ile Cys Val Glu Gln Lys Gln
      85                  90                  95

 cag ctg gaa gcc ggg cct gaa aag gcc aag ctg aag tct ttc tca gcc      511
 Gln Leu Glu Ala Gly Pro Glu Lys Ala Lys Leu Lys Ser Phe Ser Ala
 100                 105                 110                 115

 aag atc gtg cag ctc ctg aag gag tgg acc gag gcc ttc ccc tat gac      559
 Lys Ile Val Gln Leu Leu Lys Glu Trp Thr Glu Ala Phe Pro Tyr Asp
                 120                 125                 130

 ttc cag gat gag aag gcc atg gcc gag ctg aaa gcc atc aca cac cgt      607
 Phe Gln Asp Glu Lys Ala Met Ala Glu Leu Lys Ala Ile Thr His Arg
             135                 140                 145

 gtc acc cag tgt gat gag gag aat ggc aca gtg aag aag gcc att gcc      655
 Val Thr Gln Cys Asp Glu Glu Asn Gly Thr Val Lys Lys Ala Ile Ala
         150                 155                 160

 cag atg aca cag agc ctg ttg ctg tcc ttg gct gcc cgg agc cag ctc      703
 Gln Met Thr Gln Ser Leu Leu Leu Ser Leu Ala Ala Arg Ser Gln Leu
     165                 170                 175

 cag gaa ctg cga gag aag ctc cgg cca ccg gct gta gac aag ggg ccc      751
 Gln Glu Leu Arg Glu Lys Leu Arg Pro Pro Ala Val Asp Lys Gly Pro
 180                 185                 190                 195

 atc ctc aag acc aag cca cca gcc gcc cag aag gac atc ctg ggc gtg      799
 Ile Leu Lys Thr Lys Pro Pro Ala Ala Gln Lys Asp Ile Leu Gly Val
                 200                 205                 210

 tgc tgc gac ccc ctg gtg ctg gcc cag cag ctg act cac att gag ctg      847
 Cys Cys Asp Pro Leu Val Leu Ala Gln Gln Leu Thr His Ile Glu Leu
             215                 220                 225

 gac agg gtc agc agc att tac cct gag gac ttg atg cag atc gtc agc      895
 Asp Arg Val Ser Ser Ile Tyr Pro Glu Asp Leu Met Gln Ile Val Ser
         230                 235                 240

 cac atg gac tcc ttg gac aac cac agg tgc cga ggg gac ctg acc aag      943
 His Met Asp Ser Leu Asp Asn His Arg Cys Arg Gly Asp Leu Thr Lys
     245                 250                 255

 acc tac agc ctg gag gcc tat gac aac tgg ttc aac tgc ctg agc atg      991
 Thr Tyr Ser Leu Glu Ala Tyr Asp Asn Trp Phe Asn Cys Leu Ser Met
 260                 265                 270                 275

 ctg gtg gcc act gag gtg tgc cgg gtg gtg aag aag aaa cac cgg acc     1039
 Leu Val Ala Thr Glu Val Cys Arg Val Val Lys Lys Lys His Arg Thr
                 280                 285                 290

 cgc atg ttg gag ttc ttc att gat gtg gcc cgg gag tgc ttc aac atc     1087
 Arg Met Leu Glu Phe Phe Ile Asp Val Ala Arg Glu Cys Phe Asn Ile
             295                 300                 305

 ggg aac ttc aac tcc atg atg gcc atc atc tct ggc atg aac ctc agt     1135
 Gly Asn Phe Asn Ser Met Met Ala Ile Ile Ser Gly Met Asn Leu Ser
         310                 315                 320

 cct gtg gca agg ctg aag aaa act tgg tcc aag gtc aag aca gcc aag     1183
 Pro Val Ala Arg Leu Lys Lys Thr Trp Ser Lys Val Lys Thr Ala Lys
     325                 330                 335

 ttt gat gtc ttg gag cat cac atg gac ccg tcc agc aac ttc tgc aac     1231
 Phe Asp Val Leu Glu His His Met Asp Pro Ser Ser Asn Phe Cys Asn
 340                 345                 350                 355

 tac cgt aca gcc ctg cag ggg gcc acg cag agg tcc cag atg gcc aac     1279
 Tyr Arg Thr Ala Leu Gln Gly Ala Thr Gln Arg Ser Gln Met Ala Asn
                 360                 365                 370

 agc agc cgt gaa aag atc gtc atc cct gtg ttc aac ctc ttc gtt aag     1327
 Ser Ser Arg Glu Lys Ile Val Ile Pro Val Phe Asn Leu Phe Val Lys
             375                 380                 385

 gac atc tac ttc ctg cac aaa atc cat acc aac cac ctg ccc aac ggg     1375
 Asp Ile Tyr Phe Leu His Lys Ile His Thr Asn His Leu Pro Asn Gly
         390                 395                 400

 cac att aac ttt aag aaa ttc tgg gag atc tcc aga cag atc cat gag     1423
 His Ile Asn Phe Lys Lys Phe Trp Glu Ile Ser Arg Gln Ile His Glu
     405                 410                 415

 ttc atg aca tgg aca cag gta gag tgt cct ttc gag aag gac aag aag     1471
 Phe Met Thr Trp Thr Gln Val Glu Cys Pro Phe Glu Lys Asp Lys Lys
 420                 425                 430                 435

 att cag agt tac ctg ctc acg gcg ccc atc tac agc gag gaa gct ctc     1519
 Ile Gln Ser Tyr Leu Leu Thr Ala Pro Ile Tyr Ser Glu Glu Ala Leu
                 440                 445                 450

 ttc gtc gcc tcc ttt gaa agt gag ggt ccc gag aac cac atg gaa aaa     1567
 Phe Val Ala Ser Phe Glu Ser Glu Gly Pro Glu Asn His Met Glu Lys
             455                 460                 465

 gac agc tgg aag acc ctc agg acc acc ctt ctg aac aga gcc tga ggc     1615
 Asp Ser Trp Lys Thr Leu Arg Thr Thr Leu Leu Asn Arg Ala 
         470                 475                 480

 ggatgcagcc cgcgacgcca gaggaagcac gtgcactaac tgggtttaaa ttttgactga   1675

 tgtgggttga gatgaggagg cctcactggt tggggtccat tttgtatata acttttatga   1735

 gaaaaaaatg gtaattattt cacgcatcaa cctttggcac ttacaaagtt ttttttgttt   1795

 attttaaata acagggcagg gccctgcttt ggggaggggg aggggagagt atcatgggag   1855

 atggtatcca tgataacatc ttattctaat gaaatgtaga tttttatttt ctacttttga   1915

 ttattaacat cttatgaaaa aaatatttta aaaaacccag ccaaaaccaa cgtgagccct   1975

 gcctgctcgg acgcctttcc agccagtgtc tctgacgtcg gggttagtgc cttaaagggt   2035

 actggggtct ggtcttcctg ctctgtggtt tgggctgcgg tgagtcccac tccacctggg   2095

 cgcctgccct caggagcctg ggctgcgagg ctccatagga gggctggtgg ctgggaggtc   2155

 gcgtccgcac acttctggaa gtgagccttt gagtacgggc tgtccaaagt ttacattttc   2215

 attttccttt cagggatttg tggggtcagg gaggggcagg gggcacctgg cagcatattt   2275

 tctgtgacaa tgtgtccagc aaatcattct tcaactacat tttagaaagg aggaaatcta   2335

 aaataaggta agggagggaa gcatggagtt gtcagttttc tgggctgtga ctgaaagaca   2395

 cactgagctg tgatgaagaa aaatacatgg ccgactccag ggtggtgaca tttagagcta   2455

 gtcttgaaac ctatcatcta cagaggggag ggcagccaac agccctcttc ccacctgggt   2515

 aggcagcgcc ctaattggaa ttggaaacag aaaattcgcc aggccatact gctggagccc   2575

 attcagataa aactgcccaa tactgagagg tgttttctac acccagctag aggagcacac   2635

 tccattttcc catgtctgac ttcgtggtgt gagccctggg ccctactgac catggcgcag   2695

 gacagctgtc cttcagaaag cacacggtca atccacgtgg accgtctccc tcgcaggaac   2755

 tccgcatcct tgtccctctc tgcattccca gtttccgcag gagccttgat caatggggaa   2815

 gcctgggtga ggatgggcca ggtcccaatt cccaaagctc ctggaagagc ctgaagacat   2875

 tgggaaaggc tgggcctggg gaggaggcag ccctgggcct gctgcccatg cctctggtcc   2935

 tgggtggagc aggaatagtt ccactgtatt gtcacagtgt gtttgcactt tctgaggttc   2995

 tagctagtac agattgtata ttgatagtac atattgcttt gtttatgtct ttgagatgag   3055

 aaaggcttaa aacttgagaa tatatatttg gaatacagcc ttagaacggt ttctgtacac   3115

 atccacgtgc acttcacggg tgatcagttc tagtacctac ttgaaacagt gtctgtctgc   3175

 tactttattt tcccaatttg atacataccc tgatttgatg ttttggtatt tgagatgaac   3235

 tctgagtatg aagctgtacc ataatgcagg acgtcagttt tggtgtgact ggacatactt   3295

 gcttcaataa aagaatacat cactcccaaa aaaaaaaaaa aaaaaaaaag ttg          3348




      <210> 520
      <211> 1242
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1020)

      <400> 520
  atg gag tcc aag gtc tca gaa ggt ggc ctg aat gtg acc ctc acc atc      48
  Met Glu Ser Lys Val Ser Glu Gly Gly Leu Asn Val Thr Leu Thr Ile
    1               5                  10                  15

 cgc ctg ctg atg cat gga aag gaa gtt gga agc atc atc ggg aag aaa       96
 Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys
              20                  25                  30

 gga gaa act gtg aag aag atg cgt gag gag agt ggt gca agg atc aac      144
 Gly Glu Thr Val Lys Lys Met Arg Glu Glu Ser Gly Ala Arg Ile Asn
          35                  40                  45

 atc tca gag gga aac tgc cca gag agg att gtg acc atc aca ggc ccc      192
 Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Val Thr Ile Thr Gly Pro
      50                  55                  60

 aca gac gcc atc ttc aag gcc ttt gcc atg atc gca tac aag ttt gag      240
 Thr Asp Ala Ile Phe Lys Ala Phe Ala Met Ile Ala Tyr Lys Phe Glu
  65                  70                  75                  80

 gag gat atc atc aac tcc atg agc aac agc cct gcc acc agc aag ccc      288
 Glu Asp Ile Ile Asn Ser Met Ser Asn Ser Pro Ala Thr Ser Lys Pro
                  85                  90                  95

 cca gtg acg ctg agg ctg gtg gtg cct gcc agc cag tgc ggg tcc ctg      336
 Pro Val Thr Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu
             100                 105                 110

 atc ggc aaa gga ggc tcc aag atc aag gag atc agg gag tcc aca ggt      384
 Ile Gly Lys Gly Gly Ser Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly
         115                 120                 125

 gcc cag gtg cag gtg gct ggg gac atg ctg ccc aac tcc acg gag cga      432
 Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg
     130                 135                 140

 gcg gtg acc atc tcg ggg acc cca gat gcc atc atc cag tgc gtc aag      480
 Ala Val Thr Ile Ser Gly Thr Pro Asp Ala Ile Ile Gln Cys Val Lys
 145                 150                 155                 160

 cag atc tgt gtg gtc atg ctg gag tcc cca ccg aaa ggt gcc acc att      528
 Gln Ile Cys Val Val Met Leu Glu Ser Pro Pro Lys Gly Ala Thr Ile
                 165                 170                 175

 ccc tac cgc cca aag ccc gcc tcc acc cct gtc att ttt gca ggt ggt      576
 Pro Tyr Arg Pro Lys Pro Ala Ser Thr Pro Val Ile Phe Ala Gly Gly
             180                 185                 190

 cag gcc tac aca atc cag gga cag tat gcc atc cct cac ccg gat cag      624
 Gln Ala Tyr Thr Ile Gln Gly Gln Tyr Ala Ile Pro His Pro Asp Gln
         195                 200                 205

 ttg acc aag ctc cac cag ttg gcc atg cag caa acc ccc ttt cct ccc      672
 Leu Thr Lys Leu His Gln Leu Ala Met Gln Gln Thr Pro Phe Pro Pro
     210                 215                 220

 ctc gga cag acc aac ccc gct ttc ccc gga gaa aag ctg cct tta cac      720
 Leu Gly Gln Thr Asn Pro Ala Phe Pro Gly Glu Lys Leu Pro Leu His
 225                 230                 235                 240

 tcc tcc gaa gaa gct caa aat ctg atg ggc cag tca tca ggt ctg gac      768
 Ser Ser Glu Glu Ala Gln Asn Leu Met Gly Gln Ser Ser Gly Leu Asp
                 245                 250                 255

 gcc agc cca ccg gcc agc act cat gag ctc acc att ccc aat gat cta      816
 Ala Ser Pro Pro Ala Ser Thr His Glu Leu Thr Ile Pro Asn Asp Leu
             260                 265                 270

 ata ggc tgc ata att gga cgc caa ggg acc aaa atc aat gaa att cga      864
 Ile Gly Cys Ile Ile Gly Arg Gln Gly Thr Lys Ile Asn Glu Ile Arg
         275                 280                 285

 cag atg tct gga gct cag atc aaa atc gcc aac gcc acg gaa ggg tcc      912
 Gln Met Ser Gly Ala Gln Ile Lys Ile Ala Asn Ala Thr Glu Gly Ser
     290                 295                 300

 tca gag cgt cag atc acc atc acg ggg acc ccg gcc aac atc agc ctt      960
 Ser Glu Arg Gln Ile Thr Ile Thr Gly Thr Pro Ala Asn Ile Ser Leu
 305                 310                 315                 320

 gcc cag tat ctc atc aac gcc agg ctg acg tcc gag gtc acc ggg atg     1008
 Ala Gln Tyr Leu Ile Asn Ala Arg Leu Thr Ser Glu Val Thr Gly Met
                 325                 330                 335

 ggc acg ctg taa tcc tacccagcac ccttcccccg cgtcacccac ctgccagagc     1063
 Gly Thr Leu 


 ctaaggcccc cggctctcgc actctgtaca gcccaccttc cctgcctcac agataccaat   1123

 agagaggttt tcttaattaa caaaaggacg tatgccatgg agaaacacac ccgcgcacac   1183

 agctgctctc tacagaggct gcaggctccg ccgagtcccc cctcagtgtt attttattt    1242




      <210> 521
      <211> 1256
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(702)

      <400> 521
 attttgttgt attatagtaa agggaatgga ataatggaaa ttttatcatt ttgcaattaa     60

 cctttctttt cagggacagc ccatttttag ggggaaactt actgggatca attctctcta    120

 ttaaggacct caagcaatga tagaaggccc ttcattgcac tctgtctttc caatgttgct    180

 ttt  atg ctt ccc tgg caa ttt gct cag ttt ata ctt ttt aca cag ata     228
      Met Leu Pro Trp Gln Phe Ala Gln Phe Ile Leu Phe Thr Gln Ile
        1               5                  10                  15

 gca tca tta ttt ccc atg tat gtt gtg gga tac att gaa cca agc aaa      276
 Ala Ser Leu Phe Pro Met Tyr Val Val Gly Tyr Ile Glu Pro Ser Lys
                  20                  25                  30

 ttt cag aag atc att tat atg aac atg att tca gtt acc ctt agt ttc      324
 Phe Gln Lys Ile Ile Tyr Met Asn Met Ile Ser Val Thr Leu Ser Phe
              35                  40                  45

 att ttg atg ttt gga aat tca atg tac tta tct tct tct tat tct tca      372
 Ile Leu Met Phe Gly Asn Ser Met Tyr Leu Ser Ser Ser Tyr Ser Ser
          50                  55                  60

 tct ttg tta atg acg tgg gca ata att cta aag aga aat gaa att caa      420
 Ser Leu Leu Met Thr Trp Ala Ile Ile Leu Lys Arg Asn Glu Ile Gln
      65                  70                  75

 aaa ctg gga gta tct aaa ctc aac ttt tgg cta att caa ggt agt gcc      468
 Lys Leu Gly Val Ser Lys Leu Asn Phe Trp Leu Ile Gln Gly Ser Ala
  80                  85                  90                  95

 tgg tgg tgt gga aca atc att ttg aaa ttt ctg aca tct aaa atc tta      516
 Trp Trp Cys Gly Thr Ile Ile Leu Lys Phe Leu Thr Ser Lys Ile Leu
                 100                 105                 110

 ggc gtt tca gac cac att cgc ctg agt gat ctt ata gca gcc aga atc      564
 Gly Val Ser Asp His Ile Arg Leu Ser Asp Leu Ile Ala Ala Arg Ile
             115                 120                 125

 tta agg tat aca gat ttt gat act tta ata tat acc tgt gct ccc gaa      612
 Leu Arg Tyr Thr Asp Phe Asp Thr Leu Ile Tyr Thr Cys Ala Pro Glu
         130                 135                 140

 ttt gac ttc atg gaa aaa gcg act ccg ctg aga tac aca aag aca tta      660
 Phe Asp Phe Met Glu Lys Ala Thr Pro Leu Arg Tyr Thr Lys Thr Leu
     145                 150                 155

 ttg ctt cca gtt gtt atg gtg att aca tgt ttt atc ttt taa aagactg      709
 Leu Leu Pro Val Val Met Val Ile Thr Cys Phe Ile Phe 
 160                 165                 170

 ttcgtgatat ttcatatgtt ttagctacaa acatttatct aagaaaacag ctccttgaac    769

 acagtgagct ggcttttcac acattgcagt tgttagtgtt tactggccct tgccatttta    829

 attatgaggc taaagatgtt tttgacaccg cacatgtgtg ttatggcttc cttgatatgc    889

 tctcgacagc tctttggctg ggctttttcg cagagttcgt ttgagaaggt tatctttggc    949

 attttaacag tgatgtcaat acaaggttat gcaaacctcc gtaatcaatg gagcataata   1009

 ggagaattta ataattttgc cttcaggaag aaacttttta cagtggatca catacagtac   1069

 cacatcagat gctgtctttg caggtgccat gcctacaagg gcaagcatcc aagctgtctt   1129

 acacttcatc cccattgtga atccatccac atttacgaga tgcagaactt gagggccgga   1189

 ccaaaatagt tattcttact ttgtcaaaat ttgccaaaaa atagaaataa ctggtgagtc   1249

 ctgtgcc                                                             1256




      <210> 522
      <211> 1486
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(1071)

      <400> 522
 atttggccct cgaggccaag aattcggcac gaggacacga ccaag    atg gcg gcg      54
                                                      Met Ala Ala
                                                        1

 gtg tct ggc ttg gtg cgg aga ccc ctt cgg gag gtg aca gtt cgt gat      102
 Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Thr Val Arg Asp
       5                  10                  15

 gct ata aat cag ggt atg gat gag gag ctg gaa aga gat gag aag gta      150
 Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu Arg Asp Glu Lys Val
  20                  25                  30                  35

 ttt ctg ctt gga gaa gaa gtt gcc cag tat gat ggg gca tac aag gtt      198
 Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp Gly Ala Tyr Lys Val
                  40                  45                  50

 agt cga ggg ctg tgg aag aaa tat gga gac aag agg att att gac act      246
 Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys Arg Ile Ile Asp Thr
              55                  60                  65

 ccc ata tca gag atg ggc ttt gct gga att gct gta ggt gca gct atg      294
 Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala Val Gly Ala Ala Met
          70                  75                  80

 gct ggg ttg cgg ccc att tgt gaa ttt atg acc ttc aat ttc tcc atg      342
 Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr Phe Asn Phe Ser Met
      85                  90                  95

 caa gcc att gac cag gtt ata aac tca gct gcc aag acc tac tac atg      390
 Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala Lys Thr Tyr Tyr Met
 100                 105                 110                 115

 tct ggt ggc ctt cag cct gtg cct ata gtc ttc agg ggg ccc aat ggt      438
 Ser Gly Gly Leu Gln Pro Val Pro Ile Val Phe Arg Gly Pro Asn Gly
                 120                 125                 130

 gcc tca gca ggt gta gct gcc cag cac tca cag tgc ttt gct gcc tgg      486
 Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln Cys Phe Ala Ala Trp
             135                 140                 145

 tat ggg cac tgc cca ggc tta aag gtg gtc agt ccc tgg aat tca gag      534
 Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser Pro Trp Asn Ser Glu
         150                 155                 160

 gat gct aaa gga ctt att aaa tca gcc att cgg gat aac aat cca gtg      582
 Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg Asp Asn Asn Pro Val
     165                 170                 175

 gtg gtg cta gag aat gaa ttg atg tat ggg gtt cct ttt gaa ttt cct      630
 Val Val Leu Glu Asn Glu Leu Met Tyr Gly Val Pro Phe Glu Phe Pro
 180                 185                 190                 195

 ccg gaa gct cag tca aaa gat ttt ctg att cct att gga aaa gcc aaa      678
 Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro Ile Gly Lys Ala Lys
                 200                 205                 210

 ata gaa agg caa gga aca cat ata act gtg gtt tcc cat tca aga cct      726
 Ile Glu Arg Gln Gly Thr His Ile Thr Val Val Ser His Ser Arg Pro
             215                 220                 225

 gtg ggc cac tgc tta gaa gct gca gca gtg cta tct aaa gaa gga gtt      774
 Val Gly His Cys Leu Glu Ala Ala Ala Val Leu Ser Lys Glu Gly Val
         230                 235                 240

 gaa tgt gag gtg ata aat atg cgt acc att aga cca atg gac atg gaa      822
 Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg Pro Met Asp Met Glu
     245                 250                 255

 acc ata gaa gcc agt gtc atg aag aca aat cat ctt gta act gtg gaa      870
 Thr Ile Glu Ala Ser Val Met Lys Thr Asn His Leu Val Thr Val Glu
 260                 265                 270                 275

 gga ggc tgg cca cag ttt gga gta gga gct gaa atc tgt gcc agg atc      918
 Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu Ile Cys Ala Arg Ile
                 280                 285                 290

 atg gaa ggt cct gcg ttc aat ttc ctg gat gct cct gct gtt cgt gtc      966
 Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala Pro Ala Val Arg Val
             295                 300                 305

 act ggt gct gat gtc cct atg cct tat gca aag att cta gag gac aac     1014
 Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys Ile Leu Glu Asp Asn
         310                 315                 320

 tct ata cct cag gtc aaa gac atc ata ttt gca ata aag aaa aca tta     1062
 Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala Ile Lys Lys Thr Leu
     325                 330                 335

 aat att tag tttggac ttgaatatca agtcgttgaa atttatttga aatacttgct     1118
 Asn Ile 
 340

 ggcactgcac ctggatttgt actgcaagac ctgactattc ataaaggaaa acgatttcta   1178

 aagcaacagc aggtattttt gtacagggaa gtttaaatgt gtttgtgtat ggaaaactct   1238

 ccactctcct cccctagatg ccatgcttcc ttttgtctgt tacggttgcc atgttctttg   1298

 aataacaaat tatatcacat tttatcctct ctcaccacaa ggacaaagta tggatgtggc   1358

 agagtcctga tgaaagatgt atccaaacaa gataacttat atgtataaaa ttaaagcata   1418

 taatacacat ttactgttag tttgttttga taaggaataa aggaatttct aacatgaaaa   1478

 aaaaaaaa                                                            1486




      <210> 523
      <211> 1866
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(1351)

      <400> 523
 ctccaggacc cagcagggcc ctctgtccac tgctctgggc cattccccaa tcccccctcc     60

 cacttgagcc cctaactcag aatctgggac ccaggggccc ctccctaccc cagctaacct    120

 cttctggacc aggagagcca acccagatcc cactacctcc atgagtgcta cagacagg      178                                                                 
 atg ggg ccc aga gct gtg ccg ggt ctg cgg ctg gca ctg ctg ttg ctg      226
 Met Gly Pro Arg Ala Val Pro Gly Leu Arg Leu Ala Leu Leu Leu Leu
   1               5                  10                  15

 ctg gtg cta ggg aca ccc aag tca ggg gta cag ggg cag gaa ggg ctg      274
 Leu Val Leu Gly Thr Pro Lys Ser Gly Val Gln Gly Gln Glu Gly Leu
              20                  25                  30

 gac ttc cct gag tac gat ggt gtg gac cgt gtg atc aat gtc aat gca      322
 Asp Phe Pro Glu Tyr Asp Gly Val Asp Arg Val Ile Asn Val Asn Ala
          35                  40                  45

 aag aac tac aag aat gtg ttc aag aag tat gag gtg ctg gca ctc ctc      370
 Lys Asn Tyr Lys Asn Val Phe Lys Lys Tyr Glu Val Leu Ala Leu Leu
      50                  55                  60

 tac cat gaa ccc ccc gag gat gac aag gcc tca caa aga caa ttt gag      418
 Tyr His Glu Pro Pro Glu Asp Asp Lys Ala Ser Gln Arg Gln Phe Glu
  65                  70                  75                  80

 atg gag gag ctg atc ctg gag tta gca gcc caa gtc cta gaa gac aag      466
 Met Glu Glu Leu Ile Leu Glu Leu Ala Ala Gln Val Leu Glu Asp Lys
                  85                  90                  95

 ggt gtt ggc ttc ggg ctg gta gac tct gag aag gat gca gct gtg gcc      514
 Gly Val Gly Phe Gly Leu Val Asp Ser Glu Lys Asp Ala Ala Val Ala
             100                 105                 110

 aag aaa cta ggc cta act gaa gtg gac agc atg tat gta ttc aag gga      562
 Lys Lys Leu Gly Leu Thr Glu Val Asp Ser Met Tyr Val Phe Lys Gly
         115                 120                 125

 gat gaa gtc att gag tac gat ggc gag ttt tct gct gac acc atc gtg      610
 Asp Glu Val Ile Glu Tyr Asp Gly Glu Phe Ser Ala Asp Thr Ile Val
     130                 135                 140

 gag ttt ctg ctt gat gtc cta gag gac cct gtg gaa ttg att gaa ggt      658
 Glu Phe Leu Leu Asp Val Leu Glu Asp Pro Val Glu Leu Ile Glu Gly
 145                 150                 155                 160

 gaa cga gag ctg cag gcg ttt gag aat att gag gat gag atc aaa ctc      706
 Glu Arg Glu Leu Gln Ala Phe Glu Asn Ile Glu Asp Glu Ile Lys Leu
                 165                 170                 175

 att ggc tac ttc aag agc aaa gac tca gag cat tac aaa gcc ttc gag      754
 Ile Gly Tyr Phe Lys Ser Lys Asp Ser Glu His Tyr Lys Ala Phe Glu
             180                 185                 190

 gat gca gct gag gag ttt cat ccc tac atc ccc ttc ttc gcc acc ttc      802
 Asp Ala Ala Glu Glu Phe His Pro Tyr Ile Pro Phe Phe Ala Thr Phe
         195                 200                 205

 gac agc aag gtg gca aag aag ctg acc ctg aag ctg aat gag att gat      850
 Asp Ser Lys Val Ala Lys Lys Leu Thr Leu Lys Leu Asn Glu Ile Asp
     210                 215                 220

 ttc tac gag gcc ttc atg gaa gag cct gtg acc atc cca gac aag ccc      898
 Phe Tyr Glu Ala Phe Met Glu Glu Pro Val Thr Ile Pro Asp Lys Pro
 225                 230                 235                 240

 aat agc gaa gag gag att gtc aac ttc gtg gag gag cac agg aga tca      946
 Asn Ser Glu Glu Glu Ile Val Asn Phe Val Glu Glu His Arg Arg Ser
                 245                 250                 255

 acc ctg agg aaa ctg aag ccg gag agt atg tat gag acc tgg gag gat      994
 Thr Leu Arg Lys Leu Lys Pro Glu Ser Met Tyr Glu Thr Trp Glu Asp
             260                 265                 270

 gat atg gat gga atc cac att gtg gcc ttc gca gag gaa gct gat cct     1042
 Asp Met Asp Gly Ile His Ile Val Ala Phe Ala Glu Glu Ala Asp Pro
         275                 280                 285

 gat ggt ttc gag ttc tta gag act ctc aag gct gtg gcc caa gat aac     1090
 Asp Gly Phe Glu Phe Leu Glu Thr Leu Lys Ala Val Ala Gln Asp Asn
     290                 295                 300

 act gaa aac cca gat ctt agc atc atc tgg att gac cct gat gac ttc     1138
 Thr Glu Asn Pro Asp Leu Ser Ile Ile Trp Ile Asp Pro Asp Asp Phe
 305                 310                 315                 320

 ccc ctg ctg gtc cca tac tgg gag aag acg ttt gac atc gac ttg tca     1186
 Pro Leu Leu Val Pro Tyr Trp Glu Lys Thr Phe Asp Ile Asp Leu Ser
                 325                 330                 335

 gcc cca caa ata gga gtc gtc aat gtt act gat gcg gat agg cta tgg     1234
 Ala Pro Gln Ile Gly Val Val Asn Val Thr Asp Ala Asp Arg Leu Trp
             340                 345                 350

 atg gaa atg gac gat gag gag gac ctg cct tct gct gag gag ctg gag     1282
 Met Glu Met Asp Asp Glu Glu Asp Leu Pro Ser Ala Glu Glu Leu Glu
         355                 360                 365

 gac tgg ctg gag gat gtc ctg gag ggc gag atc aac aca gag gac gat     1330
 Asp Trp Leu Glu Asp Val Leu Glu Gly Glu Ile Asn Thr Glu Asp Asp
     370                 375                 380

 gac gat gat gat gat gac tag tt gctatggcaa ccatctttca gccccactgg     1383
 Asp Asp Asp Asp Asp Asp 
 385                 390

 tcttttcatg ctctctcctg ccttcccttg tccttccctg agttcctcca gggagactag   1443

 gttattctct gccatagagc taactggggt ctatatgctg ggtgctgaga cactgatccc   1503

 cctcatttga tgagcaaatg agctactttt ccctagacac caggccagct ctctcttatc   1563

 tgacttctgt ttcttatccc ataacttact tgtatctatt atgtgtctct tccatcactc   1623

 tccatactct ttcttgtgat tctcctctag ccatatatat gggccccatc tctgttctgt   1683

 tccctccatc tatgcacagc tttcccccac tctctctaat cctgtatctt tctgactgtc   1743

 ctgtccttgg ccagaaggaa gggagaatac tgtgtttggg actgtatctc agcaatcact   1803

 tgttaatgta tttgggtcaa atgagaggcc tcaataaaga catctggggc agcatgaaaa   1863

 aaa                                                                 1866




      <210> 524
      <211> 317
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (10)..(201)

      <400> 524
 cccttcacc    atg tgt tac ctg ctt ctg cta ctg atc caa act gca gaa      48
              Met Cys Tyr Leu Leu Leu Leu Leu Ile Gln Thr Ala Glu
                1               5                  10

 ctt ctc att cat ccc caa ggc ctc cag gca gta tcc aat ggg gaa tca       96
 Leu Leu Ile His Pro Gln Gly Leu Gln Ala Val Ser Asn Gly Glu Ser
      15                  20                  25

 gct cta aaa gga acc aga cca acg ttt tcc agc ccc ttc att ctg aat      144
 Ala Leu Lys Gly Thr Arg Pro Thr Phe Ser Ser Pro Phe Ile Leu Asn
  30                  35                  40                  45

 tct cca gcc ata ttt tta ttg tct atg ggg gaa gtt gga gat ggt gac      192
 Ser Pro Ala Ile Phe Leu Leu Ser Met Gly Glu Val Gly Asp Gly Asp
                  50                  55                  60

 ctt gat tag aagtgtc tggaggggga taaatggagg ggataagatt cagttggttt      248
 Leu Asp 


 tggaaaatgt taaagtctta caataatgcg tccacctagg tatcaattaa agggcaattc    308

 tgcagatat                                                            317




      <210> 525
      <211> 3819
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (159)..(2945)

      <400> 525
 caccggtccg gaattcccgg gtcgacgatt tcgtctcgcc tctcgaagga agtttgctct     60

 taatttcaga gccgggttcg ccgtcggatc aacctccagg agctagcagc gggcgcggac    120

 cgggcagttt ccgcgctcag cacaggcagc tcgcggtc    atg ggc ggc tca gcc     173
                                              Met Gly Gly Ser Ala
                                                1               5

 tcc agc cag ctg gac gag ggc aag tgc gct tac atc cga ggg aaa act      221
 Ser Ser Gln Leu Asp Glu Gly Lys Cys Ala Tyr Ile Arg Gly Lys Thr
                  10                  15                  20

 gag gct gcc atc aaa aac ttc agt ccc tac tac agt cgt cag tac tct      269
 Glu Ala Ala Ile Lys Asn Phe Ser Pro Tyr Tyr Ser Arg Gln Tyr Ser
              25                  30                  35

 gtg gct ttc tgc aat cac gtg cgc act gaa gta gaa cag caa aga gat      317
 Val Ala Phe Cys Asn His Val Arg Thr Glu Val Glu Gln Gln Arg Asp
          40                  45                  50

 tta acg tca cag ttt ttg aag acc aag cca cca ttg gcg cct gga act      365
 Leu Thr Ser Gln Phe Leu Lys Thr Lys Pro Pro Leu Ala Pro Gly Thr
      55                  60                  65

 att ttg tat gaa gca gag cta tca caa ttt tct gaa gac ata aag aag      413
 Ile Leu Tyr Glu Ala Glu Leu Ser Gln Phe Ser Glu Asp Ile Lys Lys
  70                  75                  80                  85

 tgg aag gag aga tac gtt gta gtt aaa aat gat tat gct gtg gag agc      461
 Trp Lys Glu Arg Tyr Val Val Val Lys Asn Asp Tyr Ala Val Glu Ser
                  90                  95                 100

 tat gag aat aaa gag gcc tat cag aga gga gct gct cct aaa tgt cga      509
 Tyr Glu Asn Lys Glu Ala Tyr Gln Arg Gly Ala Ala Pro Lys Cys Arg
             105                 110                 115

 att ctt cca gcc ggt ggc aag gtg tta acc tca gaa gat gaa tat aat      557
 Ile Leu Pro Ala Gly Gly Lys Val Leu Thr Ser Glu Asp Glu Tyr Asn
         120                 125                 130

 ctg ttg tct gac agg cat ttc cca gac cct ctt gcc tcc agt gag aag      605
 Leu Leu Ser Asp Arg His Phe Pro Asp Pro Leu Ala Ser Ser Glu Lys
     135                 140                 145

 gag aac act cag ccc ttt gtg gtc ctg ccc aag gaa ttc cca gtg tac      653
 Glu Asn Thr Gln Pro Phe Val Val Leu Pro Lys Glu Phe Pro Val Tyr
 150                 155                 160                 165

 ctg tgg cag ccc ttc ttc aga cac ggc tac ttc tgc ttc cac gag gct      701
 Leu Trp Gln Pro Phe Phe Arg His Gly Tyr Phe Cys Phe His Glu Ala
                 170                 175                 180

 gct gac cag aag agg ttt agt gcc ctc ctg agt gac tgc gtc agg cat      749
 Ala Asp Gln Lys Arg Phe Ser Ala Leu Leu Ser Asp Cys Val Arg His
             185                 190                 195

 ctc aat cat gat tac atg aag cag atg aca ttt gaa gcc caa gcc ttt      797
 Leu Asn His Asp Tyr Met Lys Gln Met Thr Phe Glu Ala Gln Ala Phe
         200                 205                 210

 tta gaa gct gtg caa ttc ttc cga cag gag aag ggt cac tat ggt tcc      845
 Leu Glu Ala Val Gln Phe Phe Arg Gln Glu Lys Gly His Tyr Gly Ser
     215                 220                 225

 tgg gaa atg atc act ggg gat gaa atc cag atc ctg agt aac ctg gtg      893
 Trp Glu Met Ile Thr Gly Asp Glu Ile Gln Ile Leu Ser Asn Leu Val
 230                 235                 240                 245

 atg gag gag ctc ctg ccc act ctt cag aca gac ctg ctg cct aag atg      941
 Met Glu Glu Leu Leu Pro Thr Leu Gln Thr Asp Leu Leu Pro Lys Met
                 250                 255                 260

 aag ggg aag aag aat gac aga aag agg gcg ggg ctt ggt ctc ctc gag      989
 Lys Gly Lys Lys Asn Asp Arg Lys Arg Ala Gly Leu Gly Leu Leu Glu
             265                 270                 275

 gag gcc tac acc ctg gtt cag cat caa gtt tca gaa gga tta agt gcc     1037
 Glu Ala Tyr Thr Leu Val Gln His Gln Val Ser Glu Gly Leu Ser Ala
         280                 285                 290

 ttg aag gag gaa tgc aga gct ctg aca aag ggc ctg gaa gga acg atc     1085
 Leu Lys Glu Glu Cys Arg Ala Leu Thr Lys Gly Leu Glu Gly Thr Ile
     295                 300                 305

 cgt tct gac atg gat cag att gtg aac tca aag aac tat tta att gga     1133
 Arg Ser Asp Met Asp Gln Ile Val Asn Ser Lys Asn Tyr Leu Ile Gly
 310                 315                 320                 325

 aag atc aaa gcg atg gtg gcc cag ccg gcg gag aaa agc tgc ttg gag     1181
 Lys Ile Lys Ala Met Val Ala Gln Pro Ala Glu Lys Ser Cys Leu Glu
                 330                 335                 340

 agt gtg cag cca ttc ctg gca tcc atc ctg gag gag ctc atg gga cca     1229
 Ser Val Gln Pro Phe Leu Ala Ser Ile Leu Glu Glu Leu Met Gly Pro
             345                 350                 355

 gtg agc tcg gga ttc agt gaa gta cgt gta ctc ttt gag aaa gag gtg     1277
 Val Ser Ser Gly Phe Ser Glu Val Arg Val Leu Phe Glu Lys Glu Val
         360                 365                 370

 aat gaa gtc agc cag aac ttc cag acc acc aaa gac agt gtc cag cta     1325
 Asn Glu Val Ser Gln Asn Phe Gln Thr Thr Lys Asp Ser Val Gln Leu
     375                 380                 385

 aag gag cat cta gac cgg ctt atg aat ctt ccg ctg cat tcc gtg aag     1373
 Lys Glu His Leu Asp Arg Leu Met Asn Leu Pro Leu His Ser Val Lys
 390                 395                 400                 405

 atg gaa cct tgt tat act aaa gtc aac ctg ctt cac gag cgc ctg cag     1421
 Met Glu Pro Cys Tyr Thr Lys Val Asn Leu Leu His Glu Arg Leu Gln
                 410                 415                 420

 gat ctc aag agc cgc ttc aga ttc ccc cac att gat ctg gtg gtt cag     1469
 Asp Leu Lys Ser Arg Phe Arg Phe Pro His Ile Asp Leu Val Val Gln
             425                 430                 435

 agg aca cag aac tac atg cag gag cta atg gag aat gca gtg ttc act     1517
 Arg Thr Gln Asn Tyr Met Gln Glu Leu Met Glu Asn Ala Val Phe Thr
         440                 445                 450

 ttt gag cag ttg ctt tcc cca cat ctc caa gga gag gcc tcc aaa act     1565
 Phe Glu Gln Leu Leu Ser Pro His Leu Gln Gly Glu Ala Ser Lys Thr
     455                 460                 465

 gca gtt gcc att gag aag gtt aaa ctc cga gtc tta aag caa tat gat     1613
 Ala Val Ala Ile Glu Lys Val Lys Leu Arg Val Leu Lys Gln Tyr Asp
 470                 475                 480                 485

 tat gac agc agc acc atc cga aag aag ata ttt caa gag gca cta gtt     1661
 Tyr Asp Ser Ser Thr Ile Arg Lys Lys Ile Phe Gln Glu Ala Leu Val
                 490                 495                 500

 caa atc aca ctt ccc act gtg cag aag gca ctg gcg tcc aca tgc aaa     1709
 Gln Ile Thr Leu Pro Thr Val Gln Lys Ala Leu Ala Ser Thr Cys Lys
             505                 510                 515

 cca gag ctt cag aaa tac gag cag ttc atc ttt gca gat cat acc aat     1757
 Pro Glu Leu Gln Lys Tyr Glu Gln Phe Ile Phe Ala Asp His Thr Asn
         520                 525                 530

 atg att cac gtt gaa aat gtc tat gag gag att tta cat cag atc ctg     1805
 Met Ile His Val Glu Asn Val Tyr Glu Glu Ile Leu His Gln Ile Leu
     535                 540                 545

 ctt gat gaa act ctg aaa gtg ata aag gaa gct gct atc ttg aag aaa     1853
 Leu Asp Glu Thr Leu Lys Val Ile Lys Glu Ala Ala Ile Leu Lys Lys
 550                 555                 560                 565

 cac aac tta ttt gaa gat aac atg gcc ttg ccc agt gaa agt gtg tcc     1901
 His Asn Leu Phe Glu Asp Asn Met Ala Leu Pro Ser Glu Ser Val Ser
                 570                 575                 580

 agc tta aca gat cta aag ccc ccc aca ggg tca aac cag gcc agc cct     1949
 Ser Leu Thr Asp Leu Lys Pro Pro Thr Gly Ser Asn Gln Ala Ser Pro
             585                 590                 595

 gcc agg aga gct tct gcc att ctg cca gga gtt ccg ggt agt gag acc     1997
 Ala Arg Arg Ala Ser Ala Ile Leu Pro Gly Val Pro Gly Ser Glu Thr
         600                 605                 610

 ctc agt aac gaa gta ttc cag gag tca gag gaa gag aag cag cct gag     2045
 Leu Ser Asn Glu Val Phe Gln Glu Ser Glu Glu Glu Lys Gln Pro Glu
     615                 620                 625

 gtc cct agc tcg ttg gcc aaa gga gaa agc ctt tct ctc cct ggg cca     2093
 Val Pro Ser Ser Leu Ala Lys Gly Glu Ser Leu Ser Leu Pro Gly Pro
 630                 635                 640                 645

 agc cca ccc cca gat ggg act gag cag gtg att att tca aga gtg gat     2141
 Ser Pro Pro Pro Asp Gly Thr Glu Gln Val Ile Ile Ser Arg Val Asp
                 650                 655                 660

 gac ccc gtg gtg aat cct gtg gca aca gag gac aca gca gga ctc ccg     2189
 Asp Pro Val Val Asn Pro Val Ala Thr Glu Asp Thr Ala Gly Leu Pro
             665                 670                 675

 ggc aca tgc tca tca gag ctg gag ttt gga ggg acc ctt gag gat gaa     2237
 Gly Thr Cys Ser Ser Glu Leu Glu Phe Gly Gly Thr Leu Glu Asp Glu
         680                 685                 690

 gaa ccc gcc cag gaa gag cca gaa ccc atc act gcc tcg ggt tct ttg     2285
 Glu Pro Ala Gln Glu Glu Pro Glu Pro Ile Thr Ala Ser Gly Ser Leu
     695                 700                 705

 aag gcg ctc aga aag ttg ctg aca gcg tcc gtg gaa gta cca gtg gac     2333
 Lys Ala Leu Arg Lys Leu Leu Thr Ala Ser Val Glu Val Pro Val Asp
 710                 715                 720                 725

 tct gct cca gtg atg gaa gaa gat acg aat ggg gag agc cac gtt ccc     2381
 Ser Ala Pro Val Met Glu Glu Asp Thr Asn Gly Glu Ser His Val Pro
                 730                 735                 740

 caa gaa aat gaa gaa gaa gag gaa aaa gag ccc agt cag gca gct gcc     2429
 Gln Glu Asn Glu Glu Glu Glu Glu Lys Glu Pro Ser Gln Ala Ala Ala
             745                 750                 755

 atc cac ccc gac aac tgt gaa gaa agt gaa gtc agc gag agg gag gcc     2477
 Ile His Pro Asp Asn Cys Glu Glu Ser Glu Val Ser Glu Arg Glu Ala
         760                 765                 770

 caa cct ccc tgt ccc gag gcc cat ggg gag gag ttg ggg gga ttt cca     2525
 Gln Pro Pro Cys Pro Glu Ala His Gly Glu Glu Leu Gly Gly Phe Pro
     775                 780                 785

 gag gta ggc agc cca gcc tct ccg cca gcc agt gga ggg ctc acc gag     2573
 Glu Val Gly Ser Pro Ala Ser Pro Pro Ala Ser Gly Gly Leu Thr Glu
 790                 795                 800                 805

 gag ccc ctg ggg ccc atg gag ggg gag ctc cca gga gag gcc tgc aca     2621
 Glu Pro Leu Gly Pro Met Glu Gly Glu Leu Pro Gly Glu Ala Cys Thr
                 810                 815                 820

 ctc act gcc cat gaa gga aga ggg ggc aag tgt acc gag gaa ggg gat     2669
 Leu Thr Ala His Glu Gly Arg Gly Gly Lys Cys Thr Glu Glu Gly Asp
             825                 830                 835

 gcc tca cag caa gag ggc tgc acc tta ggt tct gac ccc atc tgc ctc     2717
 Ala Ser Gln Gln Glu Gly Cys Thr Leu Gly Ser Asp Pro Ile Cys Leu
         840                 845                 850

 agt gag agc cag gtt tct gag gaa caa gaa gag atg gga ggg caa agc     2765
 Ser Glu Ser Gln Val Ser Glu Glu Gln Glu Glu Met Gly Gly Gln Ser
     855                 860                 865

 agc gcg gcc cag gcc acg gcc agt gtg aat gca gag gag atc aag gta     2813
 Ser Ala Ala Gln Ala Thr Ala Ser Val Asn Ala Glu Glu Ile Lys Val
 870                 875                 880                 885

 gcc cgt att cat gag tgt cag tgg gtg gtg gag gat gct cca aac ccg     2861
 Ala Arg Ile His Glu Cys Gln Trp Val Val Glu Asp Ala Pro Asn Pro
                 890                 895                 900

 gat gtc ctg ctg tca cac aaa gat gac gtg aag gag gga gaa ggt ggt     2909
 Asp Val Leu Leu Ser His Lys Asp Asp Val Lys Glu Gly Glu Gly Gly
             905                 910                 915

 cag gag agt ttc cca gag ctg ccc tca gag gag tga aagg gacaatttgg     2959
 Gln Glu Ser Phe Pro Glu Leu Pro Ser Glu Glu 
         920                 925

 ctgaagtctt tctctgaaaa aagccaaagg gttatagggg tacacttagg ggttgcatgc   3019

 aagctgttac caaaaaattt ttaagtattt tcttaatttg aataataaaa ccagaggaaa   3079

 tgcatacagg gcatgagcaa ctgaggcaaa cctttgtgga catgaattgt tctacgatga   3139

 atttttgctt tagtatttta ataagaatta caaagacaat ggcatacttg gggtgagagg   3199

 gagctgagga tgtctgagga gggaatagta ttgcagggaa gactgagaaa acagtaggat   3259

 gacagttttg agtatactct gcacttttca attgtgcaat cttcttgtgc actttaaggc   3319

 tttttaattt tgtttgagaa tgcaaatgta tactgtaagt ctacctttac tatctactat   3379

 gcctacttca ccatctctta aggactcggc atttgtccac agtcagactg caagagaggg   3439

 taggtcatga acagtcaccc atgctggctg tagcccccac agaggcaatc atgcccaata   3499

 gattcaagag aagctaagcg gaaatggagg gtggaaggtg tgatctgtgg gactgtctgg   3559

 gcctgttact catcctgcta tcaatttctt attaattaat cttgatgatt cttattaatt   3619

 aatcacattt gcaggaaatt cagatgaggc aagaaaattt tattggcctg ggtaagactg   3679

 aaagcattcc aaattaggct tagactgtgc aaagggctta gctaagttat cgagcttaaa   3739

 acccgtcaat taaacaaaca ttatttgaac agttactgca tgccacgcac tgtgttgggc   3799

 ttagtaataa aaaaaaaaaa                                               3819




      <210> 526
      <211> 833
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (10)..(783)

      <400> 526
 cccttcacc    atg agc atc ggc ctc ctg tgc tgt gca gcc ttg tct ctc      48
              Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu
                1               5                  10

 ctg tgg gca ggt cca gtg aat gct ggt gtc act cag acc cca aaa ttc       96
 Leu Trp Ala Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe
      15                  20                  25

 cag gtc ctg aag aca gga cag agc atg aca ctg cag tgt gcc cag gat      144
 Gln Val Leu Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp
  30                  35                  40                  45

 atg aat cat gaa tac atg tcc tgg tat cga caa gac cca ggc atg ggg      192
 Met Asn His Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly
                  50                  55                  60

 ctg agg ctg att cat tac tca gtt ggt gct ggt atc act gac caa gga      240
 Leu Arg Leu Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly
              65                  70                  75

 gaa gtc ccc aat ggc tac aat gtc tcc aga tca acc aca gag gat ttc      288
 Glu Val Pro Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe
          80                  85                  90

 cag ctc agg ctg ctg tcg gct gct ccc tcc cag aca tct gtg tac ttc      336
 Gln Leu Arg Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe
      95                 100                 105

 tgt gcc agc agg ctc ggg gac aga ggc tac acc ttc ggt tcg ggg acc      384
 Cys Ala Ser Arg Leu Gly Asp Arg Gly Tyr Thr Phe Gly Ser Gly Thr
 110                 115                 120                 125

 agg tta acc gtt gta gag gac ctg aac aag gtg ttc cca ccc gag gtc      432
 Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val
                 130                 135                 140

 gct gtg ttt gag cca tca gaa gca gag atc tcc cac acc caa aag gcc      480
 Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
             145                 150                 155

 aca ctg gtg tgc ctg gcc aca ggc ttc ttc cct gac cac gtg gag ctg      528
 Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu
         160                 165                 170

 agc tgg tgg gtg aat ggg aag gag gtg cac agt ggg gtc agc acg gac      576
 Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp
     175                 180                 185

 ccg cag ccc ctc aag gag cag ccc gcc ctc aat gac tcc aga tac tgc      624
 Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
 190                 195                 200                 205

 ctg agc agc cgc ctg agg gtc tcg gcc acc ttc tgg cag aac ccc cgc      672
 Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
                 210                 215                 220

 aac cac ttc cgc tgt caa gtc cag ttg tac ggg ctc tcg gag aat gac      720
 Asn His Phe Arg Cys Gln Val Gln Leu Tyr Gly Leu Ser Glu Asn Asp
             225                 230                 235

 gag tgg acc cag gat agg gcc aaa ccc gtc acc cag atc gtc agc gcc      768
 Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
         240                 245                 250

 gaa gcc tgg ggt tga acagactacc taggtatcaa ttaatggggt aagggcaatt      823
 Glu Ala Trp Gly 
     255

 ctgcagatat                                                           833




      <210> 527
      <211> 1424
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (542)..(1072)

      <400> 527
 gcgcccgcgg ggtaggagac ctggagctgg agaacccgcc cgccagagtc gtagtagtgg     60

 atggggagta gccgtcccat tttcaacaca tgtctcattc taaattgacg ttttggtggg    120

 ctggccgaag aaggagaaag acccgcggct ccgacctctg acctctaacc ccggacgcac    180

 tttgatttcg ccggcttgcg cggaaggctg actccctggg ccgcggcctg gcgcgggagc    240

 cgcctgtggg gtgtccccgg cgcgggaggg tgctctggtt caggcccgct gcccaggtat    300

 gcacaagtca aggccttttc tgcagaccaa gtagccttcc ctggagagcg cccccagcac    360

 cacggaaact acctacatgc cccgcggtgg tcagcccgcc ttatcccagc cccgagaccc    420

 aaaacaagaa gcatggactg aatttgaggt ttctggatgg tcgtgtgaac cgaggggacg    480

 ggtactggac tgacaagaaa tgagccttga aggtcaatct gggtgacacc cgagtctcct    540

 g    atg gag ttt cac tat gtt gcc cag gct gat ctg gaa ctc ctg acc     586
      Met Glu Phe His Tyr Val Ala Gln Ala Asp Leu Glu Leu Leu Thr
        1               5                  10                  15

 tca agc aat cca cct gcc tca gcc tcc caa agt act ggg att aca gga      634
 Ser Ser Asn Pro Pro Ala Ser Ala Ser Gln Ser Thr Gly Ile Thr Gly
                  20                  25                  30

 ggg agc cac cgt gcc cgg cct ggt cct gtg cat ttt ata gat aag gta      682
 Gly Ser His Arg Ala Arg Pro Gly Pro Val His Phe Ile Asp Lys Val
              35                  40                  45

 act gac aaa cct agc cac agt cac ccc ttc gcc cta aag gag aac tgg      730
 Thr Asp Lys Pro Ser His Ser His Pro Phe Ala Leu Lys Glu Asn Trp
          50                  55                  60

 aat ttg aac cca gag cct tct tca cca cca tct ccg ttg ttt ctg gaa      778
 Asn Leu Asn Pro Glu Pro Ser Ser Pro Pro Ser Pro Leu Phe Leu Glu
      65                  70                  75

 gca ccc tcc agg cag gcc agc cag cat cac ggg gcc tcc cct ggg gct      826
 Ala Pro Ser Arg Gln Ala Ser Gln His His Gly Ala Ser Pro Gly Ala
  80                  85                  90                  95

 gga acg tct gca gga tgc ccc ttt gag aaa tgc tgt tcc aca gaa ccc      874
 Gly Thr Ser Ala Gly Cys Pro Phe Glu Lys Cys Cys Ser Thr Glu Pro
                 100                 105                 110

 tgc ctt tca ggc ctt gga gac gtg ggc agg gga gaa gca gcg tcc ctc      922
 Cys Leu Ser Gly Leu Gly Asp Val Gly Arg Gly Glu Ala Ala Ser Leu
             115                 120                 125

 aga gcc agg cct ggc agt ggt gct agc agg ggc caa ggc cca ggg agc      970
 Arg Ala Arg Pro Gly Ser Gly Ala Ser Arg Gly Gln Gly Pro Gly Ser
         130                 135                 140

 agg gtc tcc tgt cgg agg gac ctg ggc aag ccc ctc cac gcg cca gcg     1018
 Arg Val Ser Cys Arg Arg Asp Leu Gly Lys Pro Leu His Ala Pro Ala
     145                 150                 155

 ggt ttc tca gca ggg gag gtc cac acc aca ccg ctt ggg aac ctg ggt     1066
 Gly Phe Ser Ala Gly Glu Val His Thr Thr Pro Leu Gly Asn Leu Gly
 160                 165                 170                 175

 gcc taa acgcaacagg agccaaggca caaatttaac caaacaccaa ggttgcgtga      1122
 Ala 


 gggccccatt tcatgagccg ggctccaagg acgtgtcctt aggcggctct ggaaggccca   1182

 gcgccagccc ccgtcctctg ttaaagggag ccagccccgc ggctccgccc aggcatggta   1242

 gcctgagcgc gcccccaggg tagtaggggg cacctgagga gcagggtctg ccctgggcat   1302

 gagcagagcc caggatgggg gtcagggctc aggccctggc cagaggctgg aggggtgccc   1362

 aaggcgaggc cggtgaggcc cagctctaca aataaagtgt tttatttaca ggaaaaaaaa   1422

 aa                                                                  1424




      <210> 528
      <211> 81
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(81)

      <400> 528
  atg gat aca cag gga gct tct ttc tcc tta gcc agt aat ctg ccc atg      48
  Met Asp Thr Gln Gly Ala Ser Phe Ser Leu Ala Ser Asn Leu Pro Met
    1               5                  10                  15

 atg atc cct gac agc aaa aag ttt ctt ttc tga                           81
 Met Ile Pro Asp Ser Lys Lys Phe Leu Phe 
              20                  25





      <210> 529
      <211> 4717
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(2918)

      <400> 529
 gaaagccatg tcggactcgg cgcccagcgc ccaagcgcta acccgctgaa agtttctcag     60

 cgaaatctca gggacgatct ggaccccgct gagaggaact gcttttgagt gag   atg     116
                                                              Met
                                                                1

 gtc cca gag gcc tgg agg agc gga ctg gta agc acc ggg agg gta gtg      164
 Val Pro Glu Ala Trp Arg Ser Gly Leu Val Ser Thr Gly Arg Val Val
               5                  10                  15

 gga gtt ttg ctt ctg ctt ggt gcc ttg aac aag gct tcc acg gtc att      212
 Gly Val Leu Leu Leu Leu Gly Ala Leu Asn Lys Ala Ser Thr Val Ile
          20                  25                  30

 cac tat gag atc ccg gag gaa aga gag aag ggt ttc gct gtg ggc aac      260
 His Tyr Glu Ile Pro Glu Glu Arg Glu Lys Gly Phe Ala Val Gly Asn
      35                  40                  45

 gtg gtc gcg aac ctt ggt ttg gat ctc ggt agc ctc tca gcc cgc agg      308
 Val Val Ala Asn Leu Gly Leu Asp Leu Gly Ser Leu Ser Ala Arg Arg
  50                  55                  60                  65

 ttc cgg gtg gtg tct gga gct agc cga aga ttc ttt gag gtg aac cgg      356
 Phe Arg Val Val Ser Gly Ala Ser Arg Arg Phe Phe Glu Val Asn Arg
                  70                  75                  80

 gag acc gga gag atg ttt gtg aac gac cgt ctg gat cga gag gag ctg      404
 Glu Thr Gly Glu Met Phe Val Asn Asp Arg Leu Asp Arg Glu Glu Leu
              85                  90                  95

 tgt ggg aca ctg ccc tct tgc act gta act ctg gag ttg gta gtg gag      452
 Cys Gly Thr Leu Pro Ser Cys Thr Val Thr Leu Glu Leu Val Val Glu
         100                 105                 110

 aac ccg ctg gag ctg ttc agc gtg gaa gtg gtg atc cag gac atc aac      500
 Asn Pro Leu Glu Leu Phe Ser Val Glu Val Val Ile Gln Asp Ile Asn
     115                 120                 125

 gac aac aat cct gct ttc cct acc cag gaa atg aaa ttg gag att agc      548
 Asp Asn Asn Pro Ala Phe Pro Thr Gln Glu Met Lys Leu Glu Ile Ser
 130                 135                 140                 145

 gag gcc gtg gct ccg ggg acg cgc ttt ccg ctc gag agc gcg cac gat      596
 Glu Ala Val Ala Pro Gly Thr Arg Phe Pro Leu Glu Ser Ala His Asp
                 150                 155                 160

 ccc gat gtg gga agc aac tct tta caa acc tat gag ctg agc cga aat      644
 Pro Asp Val Gly Ser Asn Ser Leu Gln Thr Tyr Glu Leu Ser Arg Asn
             165                 170                 175

 gaa tac ttt gcg ctt cgc gtg cag acg cgg gag gac agc acc aag tac      692
 Glu Tyr Phe Ala Leu Arg Val Gln Thr Arg Glu Asp Ser Thr Lys Tyr
         180                 185                 190

 gcg gag ctg gtg ttg gag cgc gcc ctg gac cga gaa cgg gag cct agt      740
 Ala Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Arg Glu Pro Ser
     195                 200                 205

 ctc cag tta gtg ctg acg gcg ttg gac gga ggg acc cca gct ctc tcc      788
 Leu Gln Leu Val Leu Thr Ala Leu Asp Gly Gly Thr Pro Ala Leu Ser
 210                 215                 220                 225

 gcc agc ctg cct att cac atc aag gtg ctg gac gcg aat gac aat gcg      836
 Ala Ser Leu Pro Ile His Ile Lys Val Leu Asp Ala Asn Asp Asn Ala
                 230                 235                 240

 cct gtc ttc aac cag tcc ttg tac cgg gcg cgc gtc ctg gag gat gca      884
 Pro Val Phe Asn Gln Ser Leu Tyr Arg Ala Arg Val Leu Glu Asp Ala
             245                 250                 255

 ccc tcc ggc acg cgc gtg gta caa gtc ctt gca acg gat ctg gat gaa      932
 Pro Ser Gly Thr Arg Val Val Gln Val Leu Ala Thr Asp Leu Asp Glu
         260                 265                 270

 ggc ccc aac ggt gaa att att tac tcc ttc ggc agc cac aac cgc gcc      980
 Gly Pro Asn Gly Glu Ile Ile Tyr Ser Phe Gly Ser His Asn Arg Ala
     275                 280                 285

 ggc gtg cgg caa cta ttc gcc tta gac ctt gta acc ggg atg ctg aca     1028
 Gly Val Arg Gln Leu Phe Ala Leu Asp Leu Val Thr Gly Met Leu Thr
 290                 295                 300                 305

 atc aag ggt cgg ctg gac ttc gag gac acc aaa ctc cat gag att tac     1076
 Ile Lys Gly Arg Leu Asp Phe Glu Asp Thr Lys Leu His Glu Ile Tyr
                 310                 315                 320

 atc cag gcc aaa gac aag ggc gcc aat ccc gaa gga gca cat tgc aaa     1124
 Ile Gln Ala Lys Asp Lys Gly Ala Asn Pro Glu Gly Ala His Cys Lys
             325                 330                 335

 gtg ttg gtg gag gtt gtg gat gtg aat gac aac gcc ccg gag atc aca     1172
 Val Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile Thr
         340                 345                 350

 gtc acc tcc gtg tac agc cca gta ccc gag gat gcc cct ctg ggg act     1220
 Val Thr Ser Val Tyr Ser Pro Val Pro Glu Asp Ala Pro Leu Gly Thr
     355                 360                 365

 gtc atc gct ttg ctc agt gtg act gac ctg gat gct ggc gag aac ggg     1268
 Val Ile Ala Leu Leu Ser Val Thr Asp Leu Asp Ala Gly Glu Asn Gly
 370                 375                 380                 385

 ctg gtg acc tgc gaa gtt cca ccg ggt ctc cct ttc agc ctt act tct     1316
 Leu Val Thr Cys Glu Val Pro Pro Gly Leu Pro Phe Ser Leu Thr Ser
                 390                 395                 400

 tcc ctc aag aat tac ttc act ttg aaa acc agt gca gac ctg gat cgg     1364
 Ser Leu Lys Asn Tyr Phe Thr Leu Lys Thr Ser Ala Asp Leu Asp Arg
             405                 410                 415

 gag act gtg cca gaa tac aac ctc agc atc acc gcc cga gac gcc gga     1412
 Glu Thr Val Pro Glu Tyr Asn Leu Ser Ile Thr Ala Arg Asp Ala Gly
         420                 425                 430

 acc cct tcc ctc tca gcc ctt aca ata gtg cgt gtt caa gtg tcc gac     1460
 Thr Pro Ser Leu Ser Ala Leu Thr Ile Val Arg Val Gln Val Ser Asp
     435                 440                 445

 atc aat gac aac cct cca caa tct tct caa tct tcc tac gac gtt tac     1508
 Ile Asn Asp Asn Pro Pro Gln Ser Ser Gln Ser Ser Tyr Asp Val Tyr
 450                 455                 460                 465

 att gaa gaa aac aac ctc ccc ggg gct cca ata cta aac cta agt gtc     1556
 Ile Glu Glu Asn Asn Leu Pro Gly Ala Pro Ile Leu Asn Leu Ser Val
                 470                 475                 480

 tgg gac ccc gac gcc ccg cag aat gct cgg ctt tct ttc ttt ctc ttg     1604
 Trp Asp Pro Asp Ala Pro Gln Asn Ala Arg Leu Ser Phe Phe Leu Leu
             485                 490                 495

 gag caa gga gct gaa acc ggg cta gtg ggt cgc tat ttc aca ata aat     1652
 Glu Gln Gly Ala Glu Thr Gly Leu Val Gly Arg Tyr Phe Thr Ile Asn
         500                 505                 510

 cgt gac aat ggc ata gtg tca tcc tta gtg ccc cta gac tat gag gat     1700
 Arg Asp Asn Gly Ile Val Ser Ser Leu Val Pro Leu Asp Tyr Glu Asp
     515                 520                 525

 cgg cgg gaa ttt gaa tta aca gct cat atc agc gat ggg ggc acc ccg     1748
 Arg Arg Glu Phe Glu Leu Thr Ala His Ile Ser Asp Gly Gly Thr Pro
 530                 535                 540                 545

 gtc cta gcc acc aac atc agc gtg aac ata ttt gtc act gat cgc aat     1796
 Val Leu Ala Thr Asn Ile Ser Val Asn Ile Phe Val Thr Asp Arg Asn
                 550                 555                 560

 gac aat gcc ccc cag gtc cta tat cct cgg cca ggt ggg agc tcg gtg     1844
 Asp Asn Ala Pro Gln Val Leu Tyr Pro Arg Pro Gly Gly Ser Ser Val
             565                 570                 575

 gag atg ctg cct cga ggt acc tca gct ggc cac cta gtg tca cgg gtg     1892
 Glu Met Leu Pro Arg Gly Thr Ser Ala Gly His Leu Val Ser Arg Val
         580                 585                 590

 gta ggc tgg gac gcg gat gca ggg cac aat gcc tgg ctc tcc tac agt     1940
 Val Gly Trp Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr Ser
     595                 600                 605

 ctc ttg gga tcc cct aac cag agc ctt ttt gcc ata ggg ctg cac act     1988
 Leu Leu Gly Ser Pro Asn Gln Ser Leu Phe Ala Ile Gly Leu His Thr
 610                 615                 620                 625

 ggt caa atc agt act gcc cgt cca gtc caa gac aca gat tca ccc agg     2036
 Gly Gln Ile Ser Thr Ala Arg Pro Val Gln Asp Thr Asp Ser Pro Arg
                 630                 635                 640

 cag act ctc acg gtc ttg atc aaa gac aat ggg gag cct tcg ctc tcc     2084
 Gln Thr Leu Thr Val Leu Ile Lys Asp Asn Gly Glu Pro Ser Leu Ser
             645                 650                 655

 acc act gct acc ctc act gtg tca gta acc gag gac tct cct gaa gcc     2132
 Thr Thr Ala Thr Leu Thr Val Ser Val Thr Glu Asp Ser Pro Glu Ala
         660                 665                 670

 cga gcc gag ttc ccc tct ggc tct gcc ccc cgg gag cag aaa aaa aat     2180
 Arg Ala Glu Phe Pro Ser Gly Ser Ala Pro Arg Glu Gln Lys Lys Asn
     675                 680                 685

 ctc acc ttt tat cta ctt ctt tcc cta atc ctg gtt tct gtg ggg ttt     2228
 Leu Thr Phe Tyr Leu Leu Leu Ser Leu Ile Leu Val Ser Val Gly Phe
 690                 695                 700                 705

 gtg gtc aca gtg ttc gga gta atc ata ttc aaa gtt tac aag tgg aag     2276
 Val Val Thr Val Phe Gly Val Ile Ile Phe Lys Val Tyr Lys Trp Lys
                 710                 715                 720

 cag tct aga gac cta tac cga gcc ccg gtg agc tca ctg tac cga aca     2324
 Gln Ser Arg Asp Leu Tyr Arg Ala Pro Val Ser Ser Leu Tyr Arg Thr
             725                 730                 735

 cca ggg ccc tcc ttg cac gcg gac gcc gtg cgg gga ggc ctg atg tcg     2372
 Pro Gly Pro Ser Leu His Ala Asp Ala Val Arg Gly Gly Leu Met Ser
         740                 745                 750

 ccg cac ctt tac cat cag gtg tat ctc acc acg gac tcc cgc ccc ggc     2420
 Pro His Leu Tyr His Gln Val Tyr Leu Thr Thr Asp Ser Arg Pro Gly
     755                 760                 765

 gac ccg ctg ctg aag aaa cct ggt gca gcc agt cca ctg gcc agc cgc     2468
 Asp Pro Leu Leu Lys Lys Pro Gly Ala Ala Ser Pro Leu Ala Ser Arg
 770                 775                 780                 785

 cag aac acg ctg cgg agc tgt gat ccg gtg ttc tat agg cag gtg ttg     2516
 Gln Asn Thr Leu Arg Ser Cys Asp Pro Val Phe Tyr Arg Gln Val Leu
                 790                 795                 800

 ggt gca gag agc gcc cct ccc gga cag caa gcc ccg ccc aac acg gac     2564
 Gly Ala Glu Ser Ala Pro Pro Gly Gln Gln Ala Pro Pro Asn Thr Asp
             805                 810                 815

 tgg cgt ttc tct cag gcc cag aga ccc ggc acc agc ggc tcc caa aat     2612
 Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn
         820                 825                 830

 ggc gat gac acc ggc acc tgg ccc aac aac cag ttt gac aca gag atg     2660
 Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met
     835                 840                 845

 ctg caa gcc atg atc ttg gcg tcc gcc agt gaa gct gct gat ggg agc     2708
 Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser
 850                 855                 860                 865

 tcc acc ctg gga ggg ggt gcc ggc acc atg gga ttg agc gcc cgc tac     2756
 Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr
                 870                 875                 880

 gga ccc cag ttc acc ctg cag cac gtg ccc gac tac cgc cag aat gtc     2804
 Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val
             885                 890                 895

 tac atc cca ggc agc aat gcc aca ctg acc aac gca gct ggc aag cgg     2852
 Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg
         900                 905                 910

 gat ggc aag gcc cca gca ggt ggc aat ggc aac aag aag aag tcg ggc     2900
 Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly
     915                 920                 925

 aag aag gag aag aag taa catgga ggccaggcca agagccacag ggcggcctct     2954
 Lys Lys Glu Lys Lys 
 930

 ccccaaccag cccagcttct ccttacctgc acccaggcct cagagtttca gggctaaccc   3014

 ccagaatact ggtaggggcc aaggccatgc tccccttggg aaacagaaac aagtgcccag   3074

 tcagcaccta ccccttcccc cccagggggt tgaatatgca aaagcagttc cgctgggaac   3134

 ccccatccaa tcaactgctg tacccatggg ggtagtgggg ttactgtaga caccaagaac   3194

 catttgccac accccgttta gttacagctg aactcctcca tcttccaaat caatcaggcc   3254

 catccatccc atgcctccct cctccccacc ccactccaac agttcctctt tcccgagtaa   3314

 ggtggttggg gtgttgaagt accaagtaac ctacaagcct cctagttctg aaaagttgga   3374

 agggcatcat gacctcttgg cctctccttt gattctcaat cttcccccaa agcatggttt   3434

 ggtgccagcc ccttcacctc cttccagagc ccaagatcaa tgctcaagtt ttggaggaca   3494

 tgatcaccat ccccatggta ctgatgcttg ctggatttag ggagggcatt ttgctaccaa   3554

 gcctcttccc aacgccctgg ggaccagtct tctgttttgt ttttcattgt ttgacgtttc   3614

 cactgcatgc cttgacttcc cccacctcct cctcaaacaa gagactccac tgcatgttcc   3674

 aagacagtat ggggtggtaa gataaggaag ggaagtgtgt ggatgtggat ggtgggggca   3734

 tggacaaagc ttgacacatc aagttatcaa ggccttggag gaggctctgt atgtcctcag   3794

 gggactgaca acatcctcca gattccagcc ataaaccaat aactaggctg gacccttccc   3854

 actacataat agggctcagc ccaggcagcc agctttgggc tgagctaaca ggaccaatgg   3914

 attaaactgg catttcagtc caaggaagct cgaagcaggt ttaggaccaa ggtccccttg   3974

 agaggtcaga ggggcctctg tgggtgctgg gtactccaga ggtgccactg gtggaagggt   4034

 cagcggagcc ccagcaggaa gggtgggcca gccaggccat tcttagtccc tgggttgggg   4094

 aggcagggag ctagggcagg gaccaaatga acagaaagtc tcagcccagg atggggcttc   4154

 ttcaacaggg cccctgccct cctgaagcct cagtccttca ccttgccagg tgccgtttct   4214

 cttccgtgaa ggccactgcc caggtcccca gtgcgccccc tagtggccat agcctggtta   4274

 aagttcccca gtgcctcctt gtgcatagac cttcttctcc cacccccttc tgcccctggg   4334

 tccccggcca tccagcgggg ctgccagaga accccagacc tgcccttaca gtagtgtagc   4394

 gccccctccc tctttcggct ggtgtagaat agccagtagt gtagtgcggt gtgcttttac   4454

 gtgatggcgg gtgggcagcg ggcggcgggc tccgcgcagc cgtctgtcct tgatctgccc   4514

 gcggcggccc gtgttgtgtt ttgtgctgtg tccacgcgct aaggcgaccc cctcccccgt   4574

 actgacttct cctataagcg cttctcttcg catagtcacg tagctcccac cccaccctct   4634

 tcctgtgtct cacgcaagtt ttatactcta atatttatat ggcttttttt cttcgacaaa   4694

 aaaataataa aacgtttctt ctg                                           4717




      <210> 530
      <211> 1134
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(1019)

      <400> 530
 attgcagagc cgctgccgga gggtcgtttt aaagggcccg cgcgttgccg ccccctcggc     60

 ccgcc    atg ctg cta tcc gtg ccg ctg ctg ctc ggc ctc ctc ggc ctg     107
          Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu
            1               5                  10

 gcc gtc gcc gag cct gcc gtc tac ttc aag gag cag ttt ctg gac gga      155
 Ala Val Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly
  15                  20                  25                  30

 gac ggg tgg act tcc cgc tgg atc gaa tcc aaa cac aag tca gat ttt      203
 Asp Gly Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe
                  35                  40                  45

 ggc aaa ttc gtt ctc agt tcc ggc aag ttc tac ggt gac gag gag aaa      251
 Gly Lys Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys
              50                  55                  60

 gat aaa ggt ttg cag aca agc cag gat gca cgc ttt tat gct ctg tcg      299
 Asp Lys Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser
          65                  70                  75

 gcc agt ttc gag cct ttc agc aac aaa ggc cag acg ctg gtg gtg cag      347
 Ala Ser Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln
      80                  85                  90

 ttc acg gtg aaa cat gag cag aac atc gac tgt ggg ggc ggc tat gtg      395
 Phe Thr Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val
  95                 100                 105                 110

 aag ctg ttt cct aat agt ttg gac cag aca gac atg cac gga gac tca      443
 Lys Leu Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser
                 115                 120                 125

 gaa tac aac atc atg ttt ggt ccc gac atc tgt ggc cct ggc acc aag      491
 Glu Tyr Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys
             130                 135                 140

 aag gtt cat gtc atc ttc aac tac aag ggc aag aac gtg ctg atc aac      539
 Lys Val His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn
         145                 150                 155

 aag gac atc cgt tgc aag gat gat gag ttt aca cac ctg tac aca ctg      587
 Lys Asp Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu
     160                 165                 170

 att gtg cgg cca gac aac acc tat gag gtg aag att gac aac agc cag      635
 Ile Val Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln
 175                 180                 185                 190

 gtg gag tcc ggc tcc ttg gaa gac gat tgg gac ttc ctg cca ccc aag      683
 Val Glu Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys
                 195                 200                 205

 aag ata aag gat cct gat gct tca aaa ccg gaa gac tgg gat gag cgg      731
 Lys Ile Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg
             210                 215                 220

 gcc aag atc gat gat ccc aca gac tcc aag cct gag gac tgg gac aag      779
 Ala Lys Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys
         225                 230                 235

 ccc gag cat atc cct gac cct gat gct aag aag ccc gag gac tgg gat      827
 Pro Glu His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp
     240                 245                 250

 gaa gag atg gac gga gag tgg gaa ccc cca gtg att cag aac cct gag      875
 Glu Glu Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu
 255                 260                 265                 270

 tac aag ggt gag tgg aag ccc cgg cag atc gac aac cca gat tac aag      923
 Tyr Lys Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys
                 275                 280                 285

 ggc act tgg atc cac cca gaa att gac aac ccc gag tat tct ccc gat      971
 Gly Thr Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp
             290                 295                 300

 ccc agt atc tat gcc tat gat aac ttt ggc gtg ctg ggg gtt att taa     1019
 Pro Ser Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Val Ile 
         305                 310                 315

 gctcttggac gagcctaaaa cttgtatcct gaagaaaata tctttttcca ccagaagaaa   1079

 ttgctttcaa tttcttaacc ttcaaaacaa tgtcagtgtt gtgcctggca tttcc        1134




      <210> 531
      <211> 499
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (53)..(370)

      <400> 531
 cacctctcct gagtcctctc tgctcacttc acctgagtcc tctactgaca cc    atg      55
                                                              Met
                                                                1

 ggt tgc tgt ggt tgt gga agt tgc ggt ggc tgt ggt ggc cgc tgc ggt      103
 Gly Cys Cys Gly Cys Gly Ser Cys Gly Gly Cys Gly Gly Arg Cys Gly
               5                  10                  15

 ggt ggc tgt ggt ggt ggc tgc agt ggt ggc tgc ggt ggt ggc tgc ggt      151
 Gly Gly Cys Gly Gly Gly Cys Ser Gly Gly Cys Gly Gly Gly Cys Gly
          20                  25                  30

 ggt ggc tgt ggt ggt ggc tgt ggc agc tgc acc acc tgc agg tgc tac      199
 Gly Gly Cys Gly Gly Gly Cys Gly Ser Cys Thr Thr Cys Arg Cys Tyr
      35                  40                  45

 cgg gtg ggc tgc tgc tcc agc tgc tgc ccc tgc tgc cgc ggc tgc tgt      247
 Arg Val Gly Cys Cys Ser Ser Cys Cys Pro Cys Cys Arg Gly Cys Cys
  50                  55                  60                  65

 gga ggc tgc tgc agc act ccc gtg atc tgc tgc tgc cgc cgc acc tgc      295
 Gly Gly Cys Cys Ser Thr Pro Val Ile Cys Cys Cys Arg Arg Thr Cys
                  70                  75                  80

 ggc tcg tgt ggc tgt ggc tat ggg aag ggc tgt tgc caa cag aaa tgc      343
 Gly Ser Cys Gly Cys Gly Tyr Gly Lys Gly Cys Cys Gln Gln Lys Cys
              85                  90                  95

 tgc tgc cag aag caa tgc tgc tgc tag gcggg cccccggcct ctgggcaggg      395
 Cys Cys Gln Lys Gln Cys Cys Cys 
         100                 105

 gctgcaggta tctgccctgt aggtaagact cccatccttc ccatcctgtc tggtctcccc    455

 ctcctctgtg gcttgaactc tgttgctagt tttctttgga ggtc                     499




      <210> 532
      <211> 5890
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (223)..(543)

      <400> 532
 atattttttt tttttttttt tttttttttt tgccaaatgt cccacgttta tttacatatg     60

 aaatgtgttt catacagtta tgatggatgg agtgcataac acctgacagc agcaagacct    120

 tttgaggaac cgaacattga ctacagtata tcatgcaagt atctatatat acacaaaaga    180

 attccttttc ttaaaaaaaa aaaaaaaaaa aaggtacaaa ac   atg ttc agg gat     234
                                                  Met Phe Arg Asp
                                                    1

 aaa tac aag ata caa aat gca aaa gaa aac aca aaa caa aac caa aaa      282
 Lys Tyr Lys Ile Gln Asn Ala Lys Glu Asn Thr Lys Gln Asn Gln Lys
   5                  10                  15                  20

 ata gaa ctc tct cag aga act ata aac gga agg gac aga aga gta cct      330
 Ile Glu Leu Ser Gln Arg Thr Ile Asn Gly Arg Asp Arg Arg Val Pro
                  25                  30                  35

 ctg ctg cat ttt aat aaa gca gaa cta ccg acg tta aat ata ctt ctt      378
 Leu Leu His Phe Asn Lys Ala Glu Leu Pro Thr Leu Asn Ile Leu Leu
              40                  45                  50

 gaa atg gct gaa cta aac ccg ggt ggc tca gtg ctt aag gta acg gcc      426
 Glu Met Ala Glu Leu Asn Pro Gly Gly Ser Val Leu Lys Val Thr Ala
          55                  60                  65

 aat tgc aat aca cag gcg gct gca ttg ata agt cgg tgg ttg aag ttg      474
 Asn Cys Asn Thr Gln Ala Ala Ala Leu Ile Ser Arg Trp Leu Lys Leu
      70                  75                  80

 tgc atc ccg act cta agt acc ata acg ttt ggc agt agc acc cag aac      522
 Cys Ile Pro Thr Leu Ser Thr Ile Thr Phe Gly Ser Ser Thr Gln Asn
  85                  90                  95                 100

 agg aaa cgc caa ctc ttt tga ca gcaaagggtt aagtcaactg atttttttct      575
 Arg Lys Arg Gln Leu Phe 
                 105

 gtcaagagcc agagaaatac ttgatattct tagctgtgtt tctgtaatag ttagttaata    635

 aattacatga caaaaacctg actatataaa tctattggtc taactacgta tttgtaactt    695

 ttatagtagt ccagcccttt cgttactttc cctccttgtg ctcttaaagc cagccttgca    755

 gatctgccga gaaaacaaat cccatttttt tctttagaat agccttcccc attcctcaaa    815

 atggaactga ggaaatcagc attccttatt agattcctag cttcagtttt tatccacggc    875

 tgggaaagga gcgacctgca agactgcttt aaacaccctt cggcatggcc tgaagacaaa    935

 ggcacgtcca cactggagtg cagttgtctc aaatgtgaac tcactccctc agggcaggca    995

 catcgaggaa gtgctaagac acttaaaagt tcctagtgtt tttgagaccc acaattactt   1055

 acaatttatg tagtgaattc taaaaattaa aaacactaaa aaaggcatta ttttagcctg   1115

 taattagtta acccattcaa aatccaaaca tacaaaatgg tttatttgaa ttcaggaact   1175

 gcccctgtta ctaagaactc tgttttaaag aaacagtaca aaaagaaaaa ttctaaccca   1235

 aaacaactca aatggttttc cactaaatac tgatacaaac atgtaacaaa gagtataaaa   1295

 agttattcat ttaaatatat acaaactctt ttaaactcaa atactgtttt aatacttatc   1355

 gaggatatat acgacgaggt gaaggaaggt acattgaaag agaatatatt gcaacagcct   1415

 agacagtact gttaactcta ttatactgca aactttgtaa caaaaatgtc ttttttattc   1475

 caatgtggac agggattttc ctcatggagc atctgtggct atttctcggc tgagctcatc   1535

 cttttggatt tgatgaaggc catgccgtgt gtccgcatgt gagtatttaa ggcagcttca   1595

 gtttcaaaag tttttgcgca cactttgcac tttctgtctg acacggcgcc atcaggggat   1655

 tcatcctcgt ggctgggttt gttctcctgt tggttatctt ccccagcccc attttgcttg   1715

 gacactggct gaggttcctt taacttgtgt acgatgaaga ggtgcctgga cagagagacg   1775

 tgagacgtgt agcagaggcc acactcccgg cactggtagg aagaaccatc cgatttgtgc   1835

 tgagggatgt gttcgtggaa ttgcagcagg ttttcggtgg tgaagccaca cacggcacac   1895

 ttgtgaacct taaaaacatt gattttcagc tttttcagtg gttgagtgat tgctcctcgg   1955

 ggaggcctga actccagaac tggttcttcc aacttccgct tgggactggg gaccttagtg   2015

 tcttctttta tttctgtttc ctcctcattg gtggcatctg tcatttcttt caggtcaggg   2075

 tccttgatgc catgcatcag ctggacgtgc ttctccagca tcaaacgttt ggtaaaggta   2135

 cgtctggagt ctgggcagtg cgagcaggcg tacactttcc tgatgccttt gtgcttgatc   2195

 cggttgtgcc ggcacaggct gtgggacgag ctgaaagact tgtcacactg gcggcagggg   2255

 tgtttcttca tttgcttccc gtgctccttc ctcacgtggg atatgtacac atctctctgc   2315

 atgaacaggc agtcacactc ccaacacgtc cacccaggac tggccacttt cttggtttcc   2375

 attgattttt tcacaggaga tggagatttc ttttccaatt tctctttccc attcatggat   2435

 ttggtgtcct ctttgttctg atttgctgaa ttttgagttg caggcttaat gctcaaaggc   2495

 aagtttatac ccaagtttgg aggcccttca atacttttca atgttccatg catagacttg   2555

 atatggtcca tcataagttg cttctgtgca tataaaagag aacagtctgg acacttgaaa   2615

 acagacacct tctggttttc aatgtgttgg tcaaagtggc gatacagcaa ggtttgcagg   2675

 gtgaacacag tgtcgcacat ggaacactta tatattattt ttggttctcc tatcttgatg   2735

 ccaggatgct gtgtgtaggc gtgggaatgt gtgcttgggg cagacttaaa cgccattgga   2795

 caaataggac acttgtagaa gacttcacag tgagaacctt gaatgtgaga cttcagagca   2855

 gccacatcag agtacacaac attgcaatgc acacatcgaa aaccaactct cctcgtgtag   2915

 tgcagacagt tcttggtgac gtgggtctgg aagtgcaccg acctgcagat ggccccacac   2975

 tcagggcagg tgtagggaga tttgtgctga tggattctct ggtgtgatgc ataactgcac   3035

 tggttaggaa gcagcatctg gcagatagtg caagtctttt gtccactcgt atctgcagcc   3095

 tgctggaaat gtgtagccag tgatgtctcg tcctggaaga cttcattaca ctccaaacat   3155

 tttagactat gtctacacag tttggagggg tcttcatcta ggggcatggc tggggtgatg   3215

 ggagtgcttg aaggagccga tatgactgtc ccagttatgc cagactgaat ttttgtgaca   3275

 gtgtgtgtgc cagctcccac agggctctga agagtggaag ttgaagtgga agtattgctt   3335

 gacggagaaa ctatcatttg atctgctggg actggcttta aaattaagtg ggagcattgc   3395

 attaccaccc ctttctcctt atgcccacgg gcatgggaaa ggaggctgca tttgttgtaa   3455

 aaaacgaggt tctttgtaca atggttgcac gttacttcga tgcgcacgct ccgtctgtcg   3515

 tagtgctggg tcagactctt ttcaagtgca aaggagtccc cacactccaa gcacttgtac   3575

 ccacgcgtcg gtaacgtgat ccctgcattg gcgggaggac tgaggtttgg gatgtaaaca   3635

 gggactggat tgacactgct cagcaccttg ttgaaagctt ccaccacaga actctgcaag   3695

 gacgacacca cctggactcg agacaccttt ttggggggtt gcgaggctgc tgcattgatt   3755

 attgcctgct ttatttgttg ctgaggtttg gttagcactt ggcggagttc agaggtggcc   3815

 tgggcaccct gaggcaaaag gttaaggttg gcaaggtgca cagtctttgg cacgagtttg   3875

 gcattggcca ggctggatgc cggcaccacg acagtttgct gctggatggc gttggcagct   3935

 ttaatgatgg cgctgctggc actctggaca gaggcagcag atatgaccgt ggctttcacc   3995

 gtggtgttgt tagcgagctt caaattaatg acttgggatc ctgccgtctt cacagcagac   4055

 actgggagga aagcagtagc cacaggcttg attgtgacct gtttgggggt gagctctgca   4115

 ggggaaactg cattggtcac gaccgcagac tggagaggcg ccctgggggg agaggaaagg   4175

 acggcggctg atgctggaga cgacagaagg gatgtcacag aggccatcac ggacgctgtc   4235

 tgctcggaag gtttctttcc agagtcaaga tccacttctg gcaataccct ggtcactgtt   4295

 ctcttgattt ccccagaaga tgtcttaatg gtttttatgc ggactttggg gattgctggt   4355

 gtggaccctg cgggagagga cggggatcct ttgctgctgt tctcacttga gatgcttctg   4415

 ggactatccg gttgcttcag ggatggtttt ttggtcccgt cgatgagatt ctgggattca   4475

 ggagacttgt cagcggctct cggactgtca tttacttctt ttggtaacgg ggaggattcc   4535

 ctcgaattgg ccactggttc tttgcaggag tctgaagccg cctttttagc gctgagagcc   4595

 gcgatggcag cgatgcagga cgagagcttg gaggacgact ttgtctttga tggcgcaacg   4655

 ctggggaggc tggtgtcatt cttctcggag ctcagcttcc catctaggac tctgttttcc   4715

 agcaccttgt cagagctttc cttcaattta tcctctgctt ttctgacttt aaaaggttca   4775

 taaacactca ggtttataga actggcttct gtttctctct taacagcttt gtttttctcc   4835

 acattgcctg acgtagagag tccagttttg ctggagtttt cccctccgag tgccttcagc   4895

 ttatcgtagt cctgctgggg agccgacccc gtcaacacat tcgacctgaa gcttgatcgc   4955

 atgtcctcct tgtcaggggg gtcatccacc tcaatcttct cgtcgtcatc aaactcttca   5015

 gcactggaga tcgggctaaa ctggctgaat gtcgagtctt tcagtgtcac ctcagaggca   5075

 ggcacatctc ctttcaagga ctttgctcca tctttactgt aactgtcaag ggaggatgct   5135

 gtgagaaacc cattatgtaa gccattgcca gtggggttgt ggccgtcttt ctccccgccc   5195

 tcggaagagt caatgttccg aacattcttg acgataacgc tgacacccac atcagaagat   5255

 gatggtgcgt gggagtcatc ctctccgtga gcattctgct tcatgtggct ttcatggtca   5315

 tcgtgtccag actcaatagc tgctttagga tcgaccatat ctgggatgtc aaatgctgcc   5375

 aggaggtcat caaagtctgg ggtcttcata tcccccatgg tcattaattt gagcagatgt   5435

 tcttgtgaac cttgaccttt tggaaagact ttagaccaat gttcagttac tgtcacacgg   5495

 ctgcattctc agcaaatagg aaagggttaa aagcagcccc agtcaacagg ccttttggcc   5555

 ttcataatag tcagaagcat ccccaacacc ctttagtagc ttctaaaaga aaaagcacaa   5615

 gacagaacat accctgcaag agaaaaaaag catgcaaagt agcattctcc agcaacaaac   5675

 aaactaccat tacaaacccc tcagttcatt ttggttttgt tttgttataa acaccgagaa   5735

 agagagagag agactgcatc aaccaagtgt ccccacccta gcaaggcaca tttttttctc   5795

 taataagggt cataaatctc agctccttgt ccatccctta agcaaaagaa aaaggcagga   5855

 aaagcccaag taatctcaga ccctgcaaac ctgca                              5890




      <210> 533
      <211> 624
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(284)

      <400> 533
 cagtgacttg ggcttgagtc tggcaaggaa ccttgctttt agcttcacca ccaaggagag     60

 aggttgac atg acc tcc ccg ccc cct cac caa ggc tgg gaa cag agg gga     110
          Met Thr Ser Pro Pro Pro His Gln Gly Trp Glu Gln Arg Gly
            1               5                  10

 tgt ggt gag agc cag gtt cct ctg gcc ctc tcc agg gtg ttt tcc act      158
 Cys Gly Glu Ser Gln Val Pro Leu Ala Leu Ser Arg Val Phe Ser Thr
  15                  20                  25                  30

 agt cac tac tgt ctt ctc ctt gta gct aat caa tca ata ttc ttc cct      206
 Ser His Tyr Cys Leu Leu Leu Val Ala Asn Gln Ser Ile Phe Phe Pro
                  35                  40                  45

 tgc ctg tgg gca gtg gag agt gct gct ggg tgt acg ctg cac ctg ccc      254
 Cys Leu Trp Ala Val Glu Ser Ala Ala Gly Cys Thr Leu His Leu Pro
              50                  55                  60

 act gag ttg ggg aaa gag gat aat cag tga g cactgttctg ctcagagctc      305
 Thr Glu Leu Gly Lys Glu Asp Asn Gln 
          65                  70

 ctgatctacc ccacccccta ggatccagga ctgggtcaaa gctgcatgaa accaggccct    365

 ggcagcaacc tgggaatggc tggaggtggg agagaacctg acttctcttt ccctctccct    425

 cctccaacat tactggaact ctatcctgtt aggatcttct gagcttgttt ccctgctggg    485

 tgggacagag gacaaaggag aagggagggt ctagaagagg cagcccttct ttgtcctctg    545

 gggtaaatga gcttgaccta gagtaaatgg agagaccaaa agcctctgat tcttaatttc    605

 cataaaatgc tagaagccg                                                 624




      <210> 534
      <211> 831
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (198)..(341)

      <400> 534
 cttgtgtctg gggcctctgt attgcgtgtg ttgcgccctg ttttcccgcc cccttttttt     60

 gtcgtttctt gttgttctgt ttcccgtcgt ctttttcttt gtgtcttcct tgttcctctc    120

 tttcttgttt tttttttttt ggcccaacga ctcggaggtt cgcctccagc ttgcgcatca    180

 tctgcggccg ggtcccg   atg agc ctc ctg ttg cct ccg ctg gcg ctg ctg     230
                      Met Ser Leu Leu Leu Pro Pro Leu Ala Leu Leu
                        1               5                  10

 ctg ctt ctc gcg gcg ctt gtg gcc cca gcc aca gcc gcc act gcc tac      278
 Leu Leu Leu Ala Ala Leu Val Ala Pro Ala Thr Ala Ala Thr Ala Tyr
              15                  20                  25

 cgg ccg gac tgg aac cgt ctg agc ggc cta acc cgc gcc cgg gta gag      326
 Arg Pro Asp Trp Asn Arg Leu Ser Gly Leu Thr Arg Ala Arg Val Glu
          30                  35                  40

 acc tgc ggg gga tga cagctgaacc gcctaaagga ggtgaaggct ttcgtcacgc      381
 Thr Cys Gly Gly 
      45

 aggacattcc attctatcac aacctggtga tgaaacacct ccctggggcc gaccctgagc    441

 tcgtgctgct gggccgccgc tacgaggaac tagagcgcat cccactcagt gaaatgaccc    501

 gcgaagagat caatgcgcta gtgcaggagc tcggcttcta ccgcaaggcg gcgcccgacg    561

 cgcaggtgcc ccccgagtac gtgtgggcgc ccgcgaagcc cccagaggaa acttcggacc    621

 acgctgacct gtaggtccgg gggcgcggcg gagctgggac ctacctgcct gagtcctgga    681

 gacagaatga agcgctcagc atcccgggaa tacttctctt gctgagagcc gatgcccgtc    741

 cccgggccag cagggatggg gttggggagg ttctcccaac cccactttct tccttcccca    801

 gctccactaa attccctcct gccttaaaaa                                     831




      <210> 535
      <211> 642
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (227)..(397)

      <220>
      <221> misc_feature
      <222> (1)...(642)
      <223> n = a,t,c or g

      <400> 535
 gcaaaaatta agttgattaa tcttcaattc tatactagta ttccaggtgt agaaagtggc     60

 tttcccagct cgcaggtgtt tccaaatctt gtcttctgat tgaaaatttg cttcccagat    120

 gacatttctc agtttttctt tttgtgaatt gcttaaccac ctaagtgttc tttcagtttt    180

 ttgcttacaa ttttaatgtg tctcattgct actggtcctc cttcta   atg tat ctg     235
                                                      Met Tyr Leu
                                                        1

 agc ttg tta att cta ctt ttg gaa aat gtc agt ggc ttt ccc ttt cct      283
 Ser Leu Leu Ile Leu Leu Leu Glu Asn Val Ser Gly Phe Pro Phe Pro
       5                  10                  15

 cta att ttc cag ctt cat gca tcc cct ggc cat aag ata ctt cca gac      331
 Leu Ile Phe Gln Leu His Ala Ser Pro Gly His Lys Ile Leu Pro Asp
  20                  25                  30                  35

 tgt atg ata tat tct atc act gtc agc ctt atg ttc cct gtg gtt gac      379
 Cys Met Ile Tyr Ser Ile Thr Val Ser Leu Met Phe Pro Val Val Asp
                  40                  45                  50

 tat ata agc acg ctt tag ggtttg ggattgtatt taggattgag agtaaaggtt      433
 Tyr Ile Ser Thr Leu 
              55

 tcctgaaagc ctagtgttcc tggattgctc tgtacgttat ttttctattt aggtcactat    493

 taaggtgcct taatccagtg aacagatgtc tatgataagt gagcatcaga gcttttgggg    553

 tactgaagtt ttgatttttg tggtggtctt aaancttccc ttgtactgta gtttgttttt    613

 aaattggcat gtatttgtat gtaataggc                                      642




      <210> 536
      <211> 887
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (644)..(754)

      <400> 536
 gaggcattga agcttgggac cctagaaatg ccatagctac aggactcagg cctgatgagc     60

 ttccagctga gcactgggtg tcactcgggc tttacctgct tatcttcagg atctctcttc    120

 tggttaggaa ccctatgcct attttgctca cttccctatt ctggtgcttt ggttggtcct    180

 ttgagcaaga tccccggggc taagggtgtg acttcatcat tcctttctct ctctttccct    240

 ctagggtcac atctcccagg aagatctcac ttccccacag aagctcttgg cctggcctcc    300

 tgcagtgccg cgctccgtgt atttgacaag ctgagttgga cactccatgt ggtagagtgt    360

 cagtttgtca agtaccccaa gtgcggcaca tgcttaccag ctctaggcca gggcagatgg    420

 gatatgacga atggactgcc agctggatac aaggatgctc accaagcacc aagttctcac    480

 aagttatttt atgtgacttt gcaggaactg aggcattata tctgaggaca ccaggggaaa    540

 agtgtggcat ctcagggaaa tacagccctg ggctgtgtct acacacacca tgagagtgct    600

 gatgggggcg caatagtctt gaaaatgtat aaagtgtcca gga  atg gaa gtg ctc     655
                                                  Met Glu Val Leu
                                                    1

 ttt gat tca tta tta ttt tct tcc ttc ata ttc ccc tcc cag agt ctc      703
 Phe Asp Ser Leu Leu Phe Ser Ser Phe Ile Phe Pro Ser Gln Ser Leu
   5                  10                  15                  20

 cta tct agg aca tca gca ttc tca cac aag tct aat ggc tta tct gag      751
 Leu Ser Arg Thr Ser Ala Phe Ser His Lys Ser Asn Gly Leu Ser Glu
                  25                  30                  35

 taa gcag ggcttagaaa ttcactttct tgatactcag tcttgccttc taaacactcc      808
 


 ttgatcttgc ctacctctcc cctaccacag cccagtactt tagttacaga aaataataaa    868

 tatttactga ttgataaaa                                                 887




      <210> 537
      <211> 959
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(930)

      <400> 537
 gaggcagagc acagcatcgt cgggaccaga ctcgtctcag gccagttgca gccttctcag     60

 ccaaacgccg accaaggaaa actcactacc     atg aga att gca gtg att tgc     111
                                      Met Arg Ile Ala Val Ile Cys
                                        1               5

 ttt tgc ctc cta ggc atc acc tgt gcc ata cca gtt aaa cag gct gat      159
 Phe Cys Leu Leu Gly Ile Thr Cys Ala Ile Pro Val Lys Gln Ala Asp
          10                  15                  20

 tct gga agt tct gag gaa aag cag aat gct gtg tcc tct gaa gaa acc      207
 Ser Gly Ser Ser Glu Glu Lys Gln Asn Ala Val Ser Ser Glu Glu Thr
      25                  30                  35

 aat gac ttt aaa caa gag acc ctt cca agt aag tcc aac gaa agc cat      255
 Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu Ser His
  40                  45                  50                  55

 gac cac atg gat gat atg gat gat gaa gat gat gat gac cat gtg gac      303
 Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His Val Asp
                  60                  65                  70

 agc cag gac tcc att gac tcg aac gac tct gat gat gta gat gac act      351
 Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp Asp Thr
              75                  80                  85

 gat gat tct cac cag tct gat gag tct cac cat tct gat gaa tct gat      399
 Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu Ser Asp
          90                  95                 100

 gaa ctg gtc act gat ttt ccc acg gac ctg cca gca acc gaa gtt ttc      447
 Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu Val Phe
     105                 110                 115

 act cca gtt gtc ccc aca gta gac aca tat gat ggc cga ggt gat agt      495
 Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly Asp Ser
 120                 125                 130                 135

 gtg gtt tat gga ctg agg tca aaa tct aag aag ttt cgc aga cct gac      543
 Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg Pro Asp
                 140                 145                 150

 atc cag tac cct gat gct aca gac gag gac atc acc tca cac atg gaa      591
 Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His Met Glu
             155                 160                 165

 agc gag gag ttg aat ggt gca tac aag gcc atc ccc gtt gcc cag gac      639
 Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala Gln Asp
         170                 175                 180

 ctg aac gcg cct tct gat tgg gac agc cgt ggg aag gac agt tat gaa      687
 Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser Tyr Glu
     185                 190                 195

 acg agt cag ctg gat gac cag agt gct gaa acc cac agc cac aag cag      735
 Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His Lys Gln
 200                 205                 210                 215

 tcc aga tta tat aag cgg aaa gct aat gat gag agc aat gag cat tcc      783
 Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu His Ser
                 220                 225                 230

 gat gtg att gat agt cag gaa ctt tcc aaa gtc agc cgt gaa ttc cac      831
 Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu Phe His
             235                 240                 245

 agc cat gaa ttt cac agc cat gaa gat atg ctg gtt gta gac ccc aaa      879
 Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp Pro Lys
         250                 255                 260

 agt aag gaa gaa gat aaa cac ctg aaa att tcc gta ttt ctc atg aat      927
 Ser Lys Glu Glu Asp Lys His Leu Lys Ile Ser Val Phe Leu Met Asn
     265                 270                 275

 tag atagtgcaac atcagagaac aaaaaaaag                                  959
 






      <210> 538
      <211> 1390
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (22)..(1362)

      <400> 538
 gaattcgagc tcgccccggc c  atg tat tcc aat gtg ata gga act gta acc      51
                          Met Tyr Ser Asn Val Ile Gly Thr Val Thr
                            1               5                  10

 tct gga aaa agg aag gtt tat ctc ttg tcc ttg ctg ctc att ggc ttc       99
 Ser Gly Lys Arg Lys Val Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe
                  15                  20                  25

 tgg gac tgc gtg acc tgt cac ggg agc cct gtg gac atc tgc aca gcc      147
 Trp Asp Cys Val Thr Cys His Gly Ser Pro Val Asp Ile Cys Thr Ala
              30                  35                  40

 aag ccg cgg gac att ccc atg aat ccc atg tgc att tac cgc tcc ccg      195
 Lys Pro Arg Asp Ile Pro Met Asn Pro Met Cys Ile Tyr Arg Ser Pro
          45                  50                  55

 gag aag aag gca act gag gat gag ggc tca gaa cag aag atc ccg gag      243
 Glu Lys Lys Ala Thr Glu Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu
      60                  65                  70

 gcc acc aac cgg cgt gtc tgg gaa ctg tcc aag gcc aat tcc cgc ttt      291
 Ala Thr Asn Arg Arg Val Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe
  75                  80                  85                  90

 gct acc act ttc tat cag cac ctg gca gat tcc aag aat gac aat gat      339
 Ala Thr Thr Phe Tyr Gln His Leu Ala Asp Ser Lys Asn Asp Asn Asp
                  95                 100                 105

 aac att ttc ctg tca ccc ctg agt atc tcc acg gct ttt gct atg acc      387
 Asn Ile Phe Leu Ser Pro Leu Ser Ile Ser Thr Ala Phe Ala Met Thr
             110                 115                 120

 aag ctg ggt gcc tgt aat gac acc ctc cag caa ctg atg gag gta ttt      435
 Lys Leu Gly Ala Cys Asn Asp Thr Leu Gln Gln Leu Met Glu Val Phe
         125                 130                 135

 aag ttt gac acc ata tct gag aaa aca tct gat cag atc cac ttc ttc      483
 Lys Phe Asp Thr Ile Ser Glu Lys Thr Ser Asp Gln Ile His Phe Phe
     140                 145                 150

 ttt gcc aaa ctg aac tgc cga ctc tat cga aaa gcc aac aaa tcc tcc      531
 Phe Ala Lys Leu Asn Cys Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser
 155                 160                 165                 170

 aag tta gta tca gcc aat cgc ctt ttt gga gac aaa tcc ctt acc ttc      579
 Lys Leu Val Ser Ala Asn Arg Leu Phe Gly Asp Lys Ser Leu Thr Phe
                 175                 180                 185

 aat gag acc tac cag gac atc agt gag ttg gta tat gga gcc aag ctc      627
 Asn Glu Thr Tyr Gln Asp Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu
             190                 195                 200

 cag ccc ctg gac ttc aag gaa ggc cga atc acc gat gtc att ccc tcg      675
 Gln Pro Leu Asp Phe Lys Glu Gly Arg Ile Thr Asp Val Ile Pro Ser
         205                 210                 215

 gaa gcc atc aat gag ctc act gtt ctg gtg ctg gtt aac acc att tac      723
 Glu Ala Ile Asn Glu Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr
     220                 225                 230

 ttc aag ggc ctg tgg aag tca aag ttc agc cct gag aac aca agg aag      771
 Phe Lys Gly Leu Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys
 235                 240                 245                 250

 gaa ctg ttc tac aag gct gat gga gag tcg tgt tca gca tct atg atg      819
 Glu Leu Phe Tyr Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met
                 255                 260                 265

 tac cag gaa ggc aag ttc cgt tat cgg cgc gtg gct gaa agc acc cag      867
 Tyr Gln Glu Gly Lys Phe Arg Tyr Arg Arg Val Ala Glu Ser Thr Gln
             270                 275                 280

 gtg ctt gag ttg ccc ttc aaa ggt gat gac atc acc atg gtc ctc atc      915
 Val Leu Glu Leu Pro Phe Lys Gly Asp Asp Ile Thr Met Val Leu Ile
         285                 290                 295

 ttg ccc aag cct gag aag agc cct gcc aag gtg gag aag gaa ctc acc      963
 Leu Pro Lys Pro Glu Lys Ser Pro Ala Lys Val Glu Lys Glu Leu Thr
     300                 305                 310

 cca gag gtg ctg cag gag tgg ctg gat gaa ttg gag gag atg atg ctg     1011
 Pro Glu Val Leu Gln Glu Trp Leu Asp Glu Leu Glu Glu Met Met Leu
 315                 320                 325                 330

 gtg gtc cac atg ccc cgc ttc cgc att gag gac ggc ttc agt ttg aag     1059
 Val Val His Met Pro Arg Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys
                 335                 340                 345

 gag cag ctg caa gac atg ggc ctt gtc gat ctg ttc agc cct gaa aag     1107
 Glu Gln Leu Gln Asp Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys
             350                 355                 360

 tcc aaa ctc cca ggt att gtt gca gaa ggc cga gat gac ctc tat gtc     1155
 Ser Lys Leu Pro Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val
         365                 370                 375

 tca gat gca ttc cat aag gca ttt ctt gag gta aat gaa gaa ggc agt     1203
 Ser Asp Ala Phe His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser
     380                 385                 390

 gaa gca gct gca agt acc gct gtt gtg att gct ggc cgt tcg cta aac     1251
 Glu Ala Ala Ala Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn
 395                 400                 405                 410

 ccc aac agg gtg act ttc aag gcc aac atg cct ttc ctg gtt ttt ata     1299
 Pro Asn Arg Val Thr Phe Lys Ala Asn Met Pro Phe Leu Val Phe Ile
                 415                 420                 425

 aga gaa gtt cct ctg aac act att atc ttc atg ggc agg gta gcc aac     1347
 Arg Glu Val Pro Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn
             430                 435                 440

 cct tgt gtt aag taa aatgttctct agaggatccc ccatcgat                  1390
 Pro Cys Val Lys 
         445





      <210> 539
      <211> 1146
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1146)

      <400> 539
  atg gca gcc gga aca gca gtt gga gcc tgg gtg ctg gtc ctc agt ctg      48
  Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu
    1               5                  10                  15

 tgg ggg gca gta gta ggt gct caa aac atc aca gcc cgg att ggc gag       96
 Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu
              20                  25                  30

 cca ctg gtg ctg aag tgt aag ggg gcc ccc aag aaa cca ccc cag cgg      144
 Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg
          35                  40                  45

 ctg gaa tgg aaa ctg aac aca ggc cgg aca gaa gct tgg aag gtc ctg      192
 Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu
      50                  55                  60

 tct ccc cag gga gga ggc cca tgg gac agt gtg gct cgt gtc ctt ccc      240
 Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro
  65                  70                  75                  80

 aac ggc tcc ctc ttc ctt ccg gct gtc ggg atc cag gat gag ggg att      288
 Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile
                  85                  90                  95

 ttc cgg tgc cag gca atg aac agg aat gga aag gag acc aag tcc aac      336
 Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn
             100                 105                 110

 tac cga gtc cgt gtc tac cag att cct ggg aag cca gaa att gta gat      384
 Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp
         115                 120                 125

 tct gcc tct gaa ctc acg gct ggt gtt ccc aat aag gtg ggg aca tgt      432
 Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys
     130                 135                 140

 gtg tca gag gga agc tac cct gca ggg act ctt agc tgg cac ttg gat      480
 Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp
 145                 150                 155                 160

 ggg aag ccc ctg gtg cct aat gag aag gga gta tct gtg aag gaa cag      528
 Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln
                 165                 170                 175

 acc agg aga cac cct gag aca ggg ctc ttc aca ctg cag tcg gag cta      576
 Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu
             180                 185                 190

 atg gtg acc cca gcc cgg gga gga gat ccc cgt ccc acc ttc tcc tgt      624
 Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys
         195                 200                 205

 agc ttc agc cca ggc ctt ccc cga cac cgg gcc ttg cgc aca gcc ccc      672
 Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro
     210                 215                 220

 atc caa ccc cgt gtc tgg gag cct gtg cct ctg gag gag gtc caa ttg      720
 Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu
 225                 230                 235                 240

 gtg gtg gag cca gaa ggt gga gca gta gct cct agt gga acc gta acc      768
 Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Ser Gly Thr Val Thr
                 245                 250                 255

 ctg acc tgt gaa gtc cct gcc cag ccc tct cct caa atc cac tgg atg      816
 Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met
             260                 265                 270

 aag gat ggt gtg ccc ttg ccc ctt ccc ccc agc cct gtg ctg atc ctc      864
 Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu
         275                 280                 285

 cct gag ata ggg cct cag gac cag gga acc tac agc tgt gtg gcc acc      912
 Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr
     290                 295                 300

 cat tcc agc cac ggg ccc cag gaa agc cgt gct gtc agc atc agc atc      960
 His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile
 305                 310                 315                 320

 atc gaa cca ggc gag gag ggg cca act gca ggc tct gtg gga gga tca     1008
 Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser
                 325                 330                 335

 ggg ctg gga act cta gcc ctg gcc ctg ggg atc ctg gga ggc ctg ggg     1056
 Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly
             340                 345                 350

 aca gcc gcc ctg ctc att ggg gtc atc ttg tgg caa agg cgg caa cgc     1104
 Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg
         355                 360                 365

 cga gga gag gag agg aag gcc cca gaa acc cag gag gaa tag             1146
 Arg Gly Glu Glu Arg Lys Ala Pro Glu Thr Gln Glu Glu 
     370                 375                 380





      <210> 540
      <211> 336
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(336)

      <400> 540
  atg gag tgg gag tgg tct tgc atg gct gtg gtg tcc cct gca gct tgt      48
  Met Glu Trp Glu Trp Ser Cys Met Ala Val Val Ser Pro Ala Ala Cys
    1               5                  10                  15

 gca ggg tat gtg gca aga ggt gct cac cac tca tct gga atg gct aga       96
 Ala Gly Tyr Val Ala Arg Gly Ala His His Ser Ser Gly Met Ala Arg
              20                  25                  30

 ctg gaa gca ctt ggc cct ctt ggg ctc tgc acc ccc acc ccc tcc cac      144
 Leu Glu Ala Leu Gly Pro Leu Gly Leu Cys Thr Pro Thr Pro Ser His
          35                  40                  45

 ctg gcc tgc ctg ctc atc ttc atg ggc gcc tgg gga gac caa tta tgg      192
 Leu Ala Cys Leu Leu Ile Phe Met Gly Ala Trp Gly Asp Gln Leu Trp
      50                  55                  60

 ctg ctt gtc ata gtg gct cag gtc acc gtt cac act tcc tgg gac cag      240
 Leu Leu Val Ile Val Ala Gln Val Thr Val His Thr Ser Trp Asp Gln
  65                  70                  75                  80

 gac atc aga gcc ctg aga agg gtc aag ggg cca agt ggg cct agc ctt      288
 Asp Ile Arg Ala Leu Arg Arg Val Lys Gly Pro Ser Gly Pro Ser Leu
                  85                  90                  95

 tta ctg aca gct ggg aaa tgc aag cgt gtg gac cag agc acc aag tga      336
 Leu Leu Thr Ala Gly Lys Cys Lys Arg Val Asp Gln Ser Thr Lys 
             100                 105                 110





      <210> 541
      <211> 5147
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (175)..(4812)

      <400> 541
 actctttttg atcagaacaa tgctgcaaaa aaagaagagt cagaaactgc caacaaaaat     60

 gattcttcaa agaagttgtc tgttgagaga gtgtatcaga agaagacaca acttgaacac    120

 attcttcttc gtcctgatac atatattggg tcagtggagc cattgacgca gttc  atg     177
                                                              Met
                                                                1

 tgg gtg tat gat gaa gat gta gga atg aat tgc agg gag gtt acc ttt      225
 Trp Val Tyr Asp Glu Asp Val Gly Met Asn Cys Arg Glu Val Thr Phe
               5                  10                  15

 gtg cca ggt tta tac aag atc ttt gat gaa att ttg gtt aat gct gct      273
 Val Pro Gly Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala
          20                  25                  30

 gac aat aaa cag agg gat aag aac atg act tgt att aaa gtt tct att      321
 Asp Asn Lys Gln Arg Asp Lys Asn Met Thr Cys Ile Lys Val Ser Ile
      35                  40                  45

 gat cct gaa tct aac att ata agc att tgg aat aat ggg aaa ggc att      369
 Asp Pro Glu Ser Asn Ile Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile
  50                  55                  60                  65

 cca gta gta gaa cac aag gtg gag aaa gtt tat gtt cct gct tta att      417
 Pro Val Val Glu His Lys Val Glu Lys Val Tyr Val Pro Ala Leu Ile
                  70                  75                  80

 ttt gga cag ctt tta aca tcc agt aac tat gat gat gat gag aaa aaa      465
 Phe Gly Gln Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys
              85                  90                  95

 gtt aca ggt ggt cgt aat ggt tat ggt gca aaa ctt tgt aat att ttc      513
 Val Thr Gly Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe
         100                 105                 110

 agt aca aag ttt aca gta gaa aca gct tgc aaa gaa tac aaa cac agt      561
 Ser Thr Lys Phe Thr Val Glu Thr Ala Cys Lys Glu Tyr Lys His Ser
     115                 120                 125

 ttt aag cag aca tgg atg aat aat atg atg aag act tct gaa gcc aaa      609
 Phe Lys Gln Thr Trp Met Asn Asn Met Met Lys Thr Ser Glu Ala Lys
 130                 135                 140                 145

 att aaa cat ttt gat ggt gaa gat tac aca tgc ata aca ttc caa cca      657
 Ile Lys His Phe Asp Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro
                 150                 155                 160

 gat ctg tcc aaa ttt aag atg gaa aaa ctt gac aag gat att gtg gcc      705
 Asp Leu Ser Lys Phe Lys Met Glu Lys Leu Asp Lys Asp Ile Val Ala
             165                 170                 175

 ctc atg act aga agg gca tat gat ttg gct ggt tcg tgt aga ggg gtc      753
 Leu Met Thr Arg Arg Ala Tyr Asp Leu Ala Gly Ser Cys Arg Gly Val
         180                 185                 190

 aag gtc atg ttt aat gga aag aaa ttg cct gta aat gga ttt cgc agt      801
 Lys Val Met Phe Asn Gly Lys Lys Leu Pro Val Asn Gly Phe Arg Ser
     195                 200                 205

 tat gta gat ctt tat gtg aaa gac aaa ttg gat gaa act ggg gtg gcc      849
 Tyr Val Asp Leu Tyr Val Lys Asp Lys Leu Asp Glu Thr Gly Val Ala
 210                 215                 220                 225

 ctg aaa gtt att cat gag ctt gca aat gaa aga tgg gat gtt tgt ctc      897
 Leu Lys Val Ile His Glu Leu Ala Asn Glu Arg Trp Asp Val Cys Leu
                 230                 235                 240

 aca ttg agt gaa aaa gga ttc cag caa atc agc ttt gta aat agt att      945
 Thr Leu Ser Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile
             245                 250                 255

 gca act aca aaa ggt gga cgg cac gtg gat tat gtg gta gat caa gtt      993
 Ala Thr Thr Lys Gly Gly Arg His Val Asp Tyr Val Val Asp Gln Val
         260                 265                 270

 gtt ggt aaa ctg att gaa gta gtt aag aaa aag aac aaa gct ggt gta     1041
 Val Gly Lys Leu Ile Glu Val Val Lys Lys Lys Asn Lys Ala Gly Val
     275                 280                 285

 tca gtg aaa cca ttt caa gta aaa aac cat ata tgg gtt ttt att aat     1089
 Ser Val Lys Pro Phe Gln Val Lys Asn His Ile Trp Val Phe Ile Asn
 290                 295                 300                 305

 tgc ctt att gaa aat cca act ttt gat tct cag act aag gaa aac atg     1137
 Cys Leu Ile Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met
                 310                 315                 320

 act ctg cag ccc aaa agt ttt ggg tct aaa tgc cag ctg tca gaa aaa     1185
 Thr Leu Gln Pro Lys Ser Phe Gly Ser Lys Cys Gln Leu Ser Glu Lys
             325                 330                 335

 ttt ttt aaa gca gcc tct aat tgt ggc att gta gaa agt atc ctg aac     1233
 Phe Phe Lys Ala Ala Ser Asn Cys Gly Ile Val Glu Ser Ile Leu Asn
         340                 345                 350

 tgg gtg aaa ttt aag gct cag act cag ctg aat aag aag tgt tca tca     1281
 Trp Val Lys Phe Lys Ala Gln Thr Gln Leu Asn Lys Lys Cys Ser Ser
     355                 360                 365

 gta aaa tac agt aaa atc aaa ggt att ccc aaa ctg gat gat gct aat     1329
 Val Lys Tyr Ser Lys Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala Asn
 370                 375                 380                 385

 gat gct ggt ggt aaa cat tcc ctg gag tgt aca ctg ata tta aca gag     1377
 Asp Ala Gly Gly Lys His Ser Leu Glu Cys Thr Leu Ile Leu Thr Glu
                 390                 395                 400

 gga gac tct gcc aaa tca ctg gct gtg tct gga tta ggt gtg att gga     1425
 Gly Asp Ser Ala Lys Ser Leu Ala Val Ser Gly Leu Gly Val Ile Gly
             405                 410                 415

 cga gac aga tac gga gtt ttt cca ctc agg ggc aaa att ctt aat gta     1473
 Arg Asp Arg Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn Val
         420                 425                 430

 cgg gaa gct tct cat aaa cag atc atg gaa aat gct gaa ata aat aat     1521
 Arg Glu Ala Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile Asn Asn
     435                 440                 445

 att att aaa ata gtt ggt cta caa tat aag aaa agt tac gat gat gca     1569
 Ile Ile Lys Ile Val Gly Leu Gln Tyr Lys Lys Ser Tyr Asp Asp Ala
 450                 455                 460                 465

 gaa tct ctg aaa acc tta cgc tat gga aag att atg att atg acc gat     1617
 Glu Ser Leu Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met Thr Asp
                 470                 475                 480

 cag gat caa gat ggt tct cac ata aaa ggc ctg ctt att aat ttc atc     1665
 Gln Asp Gln Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn Phe Ile
             485                 490                 495

 cat cac aat tgg cca tca ctt ttg aag cat ggt ttt ctt gaa gag ttc     1713
 His His Asn Trp Pro Ser Leu Leu Lys His Gly Phe Leu Glu Glu Phe
         500                 505                 510

 att act cct att gta aag gca agc aaa aat aag cag gaa ctt tcc ttc     1761
 Ile Thr Pro Ile Val Lys Ala Ser Lys Asn Lys Gln Glu Leu Ser Phe
     515                 520                 525

 tac agt att cct gaa ttt gac gaa tgg aaa aaa cat ata gaa aac cag     1809
 Tyr Ser Ile Pro Glu Phe Asp Glu Trp Lys Lys His Ile Glu Asn Gln
 530                 535                 540                 545

 aaa gcc tgg aaa ata aag tac tat aaa gga ttg ggt act agt aca gct     1857
 Lys Ala Trp Lys Ile Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr Ala
                 550                 555                 560

 aaa gaa gca aag gaa tat ttt gct gat atg gaa agg cat cgc atc ttg     1905
 Lys Glu Ala Lys Glu Tyr Phe Ala Asp Met Glu Arg His Arg Ile Leu
             565                 570                 575

 ttt aga tat gct ggt cct gaa gat gat gct gcc att acc ttg gca ttt     1953
 Phe Arg Tyr Ala Gly Pro Glu Asp Asp Ala Ala Ile Thr Leu Ala Phe
         580                 585                 590

 agt aag aag aag att gat gac aga aaa gaa tgg tta aca aat ttt atg     2001
 Ser Lys Lys Lys Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe Met
     595                 600                 605

 gaa gac cgg aga cag cgt agg cta cat ggc tta cca gag caa ttt tta     2049
 Glu Asp Arg Arg Gln Arg Arg Leu His Gly Leu Pro Glu Gln Phe Leu
 610                 615                 620                 625

 tat ggt act gca aca aag cat ttg act tat aat gat ttc atc aac aag     2097
 Tyr Gly Thr Ala Thr Lys His Leu Thr Tyr Asn Asp Phe Ile Asn Lys
                 630                 635                 640

 gaa ttg att ctc ttc tca aac tca gac aat gaa aga tct ata cca tct     2145
 Glu Leu Ile Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro Ser
             645                 650                 655

 ctt gtt gat ggc ttt aaa cct ggc cag cgg aaa gtt tta ttt acc tgt     2193
 Leu Val Asp Gly Phe Lys Pro Gly Gln Arg Lys Val Leu Phe Thr Cys
         660                 665                 670

 ttc aag agg aat gat aaa cgt gaa gta aaa gtt gcc cag ttg gct ggc     2241
 Phe Lys Arg Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu Ala Gly
     675                 680                 685

 tct gtt gct gag atg tcg gct tat cat cat gga gaa caa gca ttg atg     2289
 Ser Val Ala Glu Met Ser Ala Tyr His His Gly Glu Gln Ala Leu Met
 690                 695                 700                 705

 atg act att gtg aat ttg gct cag aac ttt gtg gga agt aac aac att     2337
 Met Thr Ile Val Asn Leu Ala Gln Asn Phe Val Gly Ser Asn Asn Ile
                 710                 715                 720

 aac ttg ctt cag cct att ggt cag ttt gga act cgg ctt cat ggt ggc     2385
 Asn Leu Leu Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His Gly Gly
             725                 730                 735

 aaa gat gct gca agc cct cgt tat att ttc aca atg tta agc act tta     2433
 Lys Asp Ala Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser Thr Leu
         740                 745                 750

 gca agg cta ctt ttt cct gct gtg gat gac aac ctc ctt aag ttc ctt     2481
 Ala Arg Leu Leu Phe Pro Ala Val Asp Asp Asn Leu Leu Lys Phe Leu
     755                 760                 765

 tat gat gat aat caa cgt gta gag cct gag tgg tat att cct ata att     2529
 Tyr Asp Asp Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile Ile
 770                 775                 780                 785

 ccc atg gtt tta ata aat ggt gct gag ggc att ggt act gga tgg gct     2577
 Pro Met Val Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp Ala
                 790                 795                 800

 tgt aaa cta ccc aac tat gat gct agg gaa att gtg aac aat gtc aga     2625
 Cys Lys Leu Pro Asn Tyr Asp Ala Arg Glu Ile Val Asn Asn Val Arg
             805                 810                 815

 cga atg cta gat ggc ctg gat cct cat ccc atg ctt cca aac tac aaa     2673
 Arg Met Leu Asp Gly Leu Asp Pro His Pro Met Leu Pro Asn Tyr Lys
         820                 825                 830

 aac ttt aaa ggc acg att caa gaa ctt ggt caa aac cag tat gca gtc     2721
 Asn Phe Lys Gly Thr Ile Gln Glu Leu Gly Gln Asn Gln Tyr Ala Val
     835                 840                 845

 agt ggt gaa ata ttt gta gtg gac aga aac aca gta gaa att aca gag     2769
 Ser Gly Glu Ile Phe Val Val Asp Arg Asn Thr Val Glu Ile Thr Glu
 850                 855                 860                 865

 ctt cca gtt aga act tgg aca cag gta tat aaa gaa cag gtt tta gaa     2817
 Leu Pro Val Arg Thr Trp Thr Gln Val Tyr Lys Glu Gln Val Leu Glu
                 870                 875                 880

 cct atg cta aat gga aca gat aaa aca cca gca tta att tct gat tat     2865
 Pro Met Leu Asn Gly Thr Asp Lys Thr Pro Ala Leu Ile Ser Asp Tyr
             885                 890                 895

 aaa gaa tat cat act gac aca act gtg aaa ttt gtg gtg aaa atg act     2913
 Lys Glu Tyr His Thr Asp Thr Thr Val Lys Phe Val Val Lys Met Thr
         900                 905                 910

 gaa gag aaa cta gca caa gca gaa gct gct gga ctg cat aaa gtt ttt     2961
 Glu Glu Lys Leu Ala Gln Ala Glu Ala Ala Gly Leu His Lys Val Phe
     915                 920                 925

 aaa ctt caa act act ctt act tgt aat tcc atg gta ctt ttt gat cat     3009
 Lys Leu Gln Thr Thr Leu Thr Cys Asn Ser Met Val Leu Phe Asp His
 930                 935                 940                 945

 atg gga tgt ctg aag aaa tat gaa act gtg caa gac att ctg aaa gaa     3057
 Met Gly Cys Leu Lys Lys Tyr Glu Thr Val Gln Asp Ile Leu Lys Glu
                 950                 955                 960

 ttc ttt gat tta cga tta agt tat tac ggt tta cgt aag gag tgg ctt     3105
 Phe Phe Asp Leu Arg Leu Ser Tyr Tyr Gly Leu Arg Lys Glu Trp Leu
             965                 970                 975

 gtg gga atg ttg gga gca gaa tct aca aag ctt aac aat caa gcc cgt     3153
 Val Gly Met Leu Gly Ala Glu Ser Thr Lys Leu Asn Asn Gln Ala Arg
         980                 985                 990

 ttc att tta gag aag ata caa ggg aaa att act ata gag aat agg tca     3201
 Phe Ile Leu Glu Lys Ile Gln Gly Lys Ile Thr Ile Glu Asn Arg Ser
     995                1000                1005

 aag aaa gat ttg att caa atg tta gtc cag aga ggt tat gaa tct gac     3249
 Lys Lys Asp Leu Ile Gln Met Leu Val Gln Arg Gly Tyr Glu Ser Asp
1010                1015                1020                1025

 cca gtg aaa gcc tgg aaa gaa gca caa gaa aag gca gca gaa gag gat     3297
 Pro Val Lys Ala Trp Lys Glu Ala Gln Glu Lys Ala Ala Glu Glu Asp
                1030                1035                1040

 gaa aca caa aac cag cat gat gat agt tcc tcc gat tca gga act cct     3345
 Glu Thr Gln Asn Gln His Asp Asp Ser Ser Ser Asp Ser Gly Thr Pro
            1045                1050                1055

 tca ggc cca gat ttt aat tat att tta aat atg tct ctg tgg tct ctt     3393
 Ser Gly Pro Asp Phe Asn Tyr Ile Leu Asn Met Ser Leu Trp Ser Leu
        1060                1065                1070

 act aaa gaa aaa gtt gaa gaa ctg att aaa cag aga gat gca aaa ggg     3441
 Thr Lys Glu Lys Val Glu Glu Leu Ile Lys Gln Arg Asp Ala Lys Gly
    1075                1080                1085

 cga gag gtc aat gat ctt aaa aga aaa tct cct tca gat ctt tgg aaa     3489
 Arg Glu Val Asn Asp Leu Lys Arg Lys Ser Pro Ser Asp Leu Trp Lys
1090                1095                1100                1105

 gag gat tta gcg gca ttt gtt gaa gaa ctg gat aaa gtg gaa tct caa     3537
 Glu Asp Leu Ala Ala Phe Val Glu Glu Leu Asp Lys Val Glu Ser Gln
                1110                1115                1120

 gaa cga gaa gat gtt ctg gct gga atg tct gga aaa gca att aaa ggt     3585
 Glu Arg Glu Asp Val Leu Ala Gly Met Ser Gly Lys Ala Ile Lys Gly
            1125                1130                1135

 aaa gtt ggc aaa cct aag gtg aag aaa ctc cag ttg gaa gag aca atg     3633
 Lys Val Gly Lys Pro Lys Val Lys Lys Leu Gln Leu Glu Glu Thr Met
        1140                1145                1150

 ccc tca cct tat ggc aga aga ata att cct gaa att aca gct atg aag     3681
 Pro Ser Pro Tyr Gly Arg Arg Ile Ile Pro Glu Ile Thr Ala Met Lys
    1155                1160                1165

 gca gat gcc agc aaa aag ttg ctg aag aag aag aag ggt gat ctt gat     3729
 Ala Asp Ala Ser Lys Lys Leu Leu Lys Lys Lys Lys Gly Asp Leu Asp
1170                1175                1180                1185

 act gca gca gta aaa gtg gaa ttt gat gaa gaa ttc agt gga gca cca     3777
 Thr Ala Ala Val Lys Val Glu Phe Asp Glu Glu Phe Ser Gly Ala Pro
                1190                1195                1200

 gta gaa ggt gca gga gaa gag gca ttg act cca tca gtt cct ata aat     3825
 Val Glu Gly Ala Gly Glu Glu Ala Leu Thr Pro Ser Val Pro Ile Asn
            1205                1210                1215

 aaa ggt ccc aaa cct aag agg gag aag aag gag cct ggt acc aga gtg     3873
 Lys Gly Pro Lys Pro Lys Arg Glu Lys Lys Glu Pro Gly Thr Arg Val
        1220                1225                1230

 aga aaa aca cct aca tca tct ggt aaa cct agt gca aag aaa gtg aag     3921
 Arg Lys Thr Pro Thr Ser Ser Gly Lys Pro Ser Ala Lys Lys Val Lys
    1235                1240                1245

 aaa cgg aat cct tgg tca gat gat gaa tcc aag tca gaa agt gat ttg     3969
 Lys Arg Asn Pro Trp Ser Asp Asp Glu Ser Lys Ser Glu Ser Asp Leu
1250                1255                1260                1265

 gaa gaa aca gaa cct gtg gtt att cca aga gat tct ttg ctt agg aga     4017
 Glu Glu Thr Glu Pro Val Val Ile Pro Arg Asp Ser Leu Leu Arg Arg
                1270                1275                1280

 gca gca gcc gaa aga cct aaa tac aca ttt gat ttc tca gaa gaa gag     4065
 Ala Ala Ala Glu Arg Pro Lys Tyr Thr Phe Asp Phe Ser Glu Glu Glu
            1285                1290                1295

 gat gat gat gct gat gat gat gat gat gac aat aat gat tta gag gaa     4113
 Asp Asp Asp Ala Asp Asp Asp Asp Asp Asp Asn Asn Asp Leu Glu Glu
        1300                1305                1310

 ttg aaa gtt aaa gca tct ccc ata aca aat gat ggg gaa gat gaa ttt     4161
 Leu Lys Val Lys Ala Ser Pro Ile Thr Asn Asp Gly Glu Asp Glu Phe
    1315                1320                1325

 gtt cct tca gat ggg tta gat aaa gat gaa tat aca ttt tca cca ggc     4209
 Val Pro Ser Asp Gly Leu Asp Lys Asp Glu Tyr Thr Phe Ser Pro Gly
1330                1335                1340                1345

 aaa tca aaa gcc act cca gaa aaa tct ttg cat gac aaa aaa agt cag     4257
 Lys Ser Lys Ala Thr Pro Glu Lys Ser Leu His Asp Lys Lys Ser Gln
                1350                1355                1360

 gat ttt gga aat ctc ttc tca ttt cct tca tat tct cag aag tca gaa     4305
 Asp Phe Gly Asn Leu Phe Ser Phe Pro Ser Tyr Ser Gln Lys Ser Glu
            1365                1370                1375

 gat gat tca gct aaa ttt gac agt aat gaa gaa gat tct gct tct gtt     4353
 Asp Asp Ser Ala Lys Phe Asp Ser Asn Glu Glu Asp Ser Ala Ser Val
        1380                1385                1390

 ttt tca cca tca ttt ggt ctg aaa cag aca gat aaa gtt cca agt aaa     4401
 Phe Ser Pro Ser Phe Gly Leu Lys Gln Thr Asp Lys Val Pro Ser Lys
    1395                1400                1405

 acg gta gct gct aaa aag gga aaa ccg tct tca gat aca gtc cct aag     4449
 Thr Val Ala Ala Lys Lys Gly Lys Pro Ser Ser Asp Thr Val Pro Lys
1410                1415                1420                1425

 ccc aag aga gcc cca aaa cag aag aaa gta gta gag gct gta aac tct     4497
 Pro Lys Arg Ala Pro Lys Gln Lys Lys Val Val Glu Ala Val Asn Ser
                1430                1435                1440

 gac tcg gat tca gaa ttt ggc att cca aag aag act aca aca cca aaa     4545
 Asp Ser Asp Ser Glu Phe Gly Ile Pro Lys Lys Thr Thr Thr Pro Lys
            1445                1450                1455

 ggt aaa ggc cga ggg gca aag aaa agg aaa gca tct ggc tct gaa aat     4593
 Gly Lys Gly Arg Gly Ala Lys Lys Arg Lys Ala Ser Gly Ser Glu Asn
        1460                1465                1470

 gaa ggc gat tat aac cct ggc agg aaa aca tcc aaa aca aca agc aag     4641
 Glu Gly Asp Tyr Asn Pro Gly Arg Lys Thr Ser Lys Thr Thr Ser Lys
    1475                1480                1485

 aaa ccg aag aag aca tct ttt gat cag gat tca gat gtg gac atc ttc     4689
 Lys Pro Lys Lys Thr Ser Phe Asp Gln Asp Ser Asp Val Asp Ile Phe
1490                1495                1500                1505

 ccc tca gac ttc cct act gag cca cct tct ctg cca cga acc ggt cgg     4737
 Pro Ser Asp Phe Pro Thr Glu Pro Pro Ser Leu Pro Arg Thr Gly Arg
                1510                1515                1520

 gct agg aaa gaa gta aaa tat ttt gca gag tct gat gaa gaa gaa gat     4785
 Ala Arg Lys Glu Val Lys Tyr Phe Ala Glu Ser Asp Glu Glu Glu Asp
            1525                1530                1535

 gat gtt gat ttt gca atg ttt aat taa gtgcc caaagagcac aaacattttt     4837
 Asp Val Asp Phe Ala Met Phe Asn 
        1540                1545

 caacaaatat cttgtgttgt ccttttgtct tctctgtctc agacttttgt acatctggct   4897

 tattttaatg tgatgatgta attgacggtt ttttattatt gtggtaggcc ttttaacatt   4957

 ttgttcttac acatacagtt ttatgctctt ttttactcat tgaaatgtca cgtactgtct   5017

 gattggcttg tagaattgtt atagactgcc gtgcattagc acagatttta attgtcatgg   5077

 ttacaaacta cagacctgct ttttgaaatg aaatttaaac attaaaaatg gaactgtgaa   5137

 aaaaaaaaaa                                                          5147




      <210> 542
      <211> 1977
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1977)

      <400> 542
  atg cgg gct ccg ggt gcg ggc gcg gcc tcg gtg gtc tcg ctg gcg ctg      48
  Met Arg Ala Pro Gly Ala Gly Ala Ala Ser Val Val Ser Leu Ala Leu
    1               5                  10                  15

 ttg tgg ctg ctg ggg ctg ccg tgg acc tgg agc gcg gca gcg gcg ctc       96
 Leu Trp Leu Leu Gly Leu Pro Trp Thr Trp Ser Ala Ala Ala Ala Leu
              20                  25                  30

 ggc gtg tac gtg ggc agc ggc ggc tgg cgc ttc ctg cgc atc gtc tgc      144
 Gly Val Tyr Val Gly Ser Gly Gly Trp Arg Phe Leu Arg Ile Val Cys
          35                  40                  45

 aag acc gcg agg cga gac ctc ttc ggt ctc tct gtg ctg atc cgc gtg      192
 Lys Thr Ala Arg Arg Asp Leu Phe Gly Leu Ser Val Leu Ile Arg Val
      50                  55                  60

 cgc ctg gag ctg cgg cgg cac cag cgt gcc ggc cac acc atc ccg cgc      240
 Arg Leu Glu Leu Arg Arg His Gln Arg Ala Gly His Thr Ile Pro Arg
  65                  70                  75                  80

 atc ttt cag gcg gta gtg cag cga cag ccc gag cgc ctg gcg ctg gtg      288
 Ile Phe Gln Ala Val Val Gln Arg Gln Pro Glu Arg Leu Ala Leu Val
                  85                  90                  95

 gat gcc ggg acc ggc gag tgc tgg acc ttt gcg cag ctg gac gcc tac      336
 Asp Ala Gly Thr Gly Glu Cys Trp Thr Phe Ala Gln Leu Asp Ala Tyr
             100                 105                 110

 tcc aat gcg gta gcc aac ctc ttc cgc cag ctg ggc ttc gcg ccg ggc      384
 Ser Asn Ala Val Ala Asn Leu Phe Arg Gln Leu Gly Phe Ala Pro Gly
         115                 120                 125

 gac gtg gtg gcc atc ttc ctg gag ggc cgg ccg gag ttc gtg ggg ctg      432
 Asp Val Val Ala Ile Phe Leu Glu Gly Arg Pro Glu Phe Val Gly Leu
     130                 135                 140

 tgg ctg ggc ctg gcc aag gcg ggc atg gag gcc gcg ctg ctc aac gtg      480
 Trp Leu Gly Leu Ala Lys Ala Gly Met Glu Ala Ala Leu Leu Asn Val
 145                 150                 155                 160

 aac ctg cgg cgc gag ccc ctg gcc ttc tgc ctg ggc acc tcg ggc gct      528
 Asn Leu Arg Arg Glu Pro Leu Ala Phe Cys Leu Gly Thr Ser Gly Ala
                 165                 170                 175

 aag gcc ctg atc ttt gga gga gaa atg gtg gcg gcg gtg gcc gaa gtg      576
 Lys Ala Leu Ile Phe Gly Gly Glu Met Val Ala Ala Val Ala Glu Val
             180                 185                 190

 agc ggg cat ctg ggg aaa agt ttg atc aag ttc tgc tct gga gac ttg      624
 Ser Gly His Leu Gly Lys Ser Leu Ile Lys Phe Cys Ser Gly Asp Leu
         195                 200                 205

 ggg ccc gag ggc atc ttg ccg gac acc cac ctc ctg gac ccg ctg ctg      672
 Gly Pro Glu Gly Ile Leu Pro Asp Thr His Leu Leu Asp Pro Leu Leu
     210                 215                 220

 aag gag gcc tct act gcc ccc ttg gca cag atc ccc agc aag ggc atg      720
 Lys Glu Ala Ser Thr Ala Pro Leu Ala Gln Ile Pro Ser Lys Gly Met
 225                 230                 235                 240

 gac gat cgt ctt ttc tac atc tac acg tcg ggg acc acc ggg ctg ccc      768
 Asp Asp Arg Leu Phe Tyr Ile Tyr Thr Ser Gly Thr Thr Gly Leu Pro
                 245                 250                 255

 aag gct gcc att gtc gtg cac agc agg tac tac cgc atg gca gcc ttc      816
 Lys Ala Ala Ile Val Val His Ser Arg Tyr Tyr Arg Met Ala Ala Phe
             260                 265                 270

 ggc cac cac gcc tac cgc atg cag gcg gct gac gtg ctc tat gac tgc      864
 Gly His His Ala Tyr Arg Met Gln Ala Ala Asp Val Leu Tyr Asp Cys
         275                 280                 285

 ctg ccc ctg tac cac tcg gca gga aac atc atc ggc gtg ggg cag tgt      912
 Leu Pro Leu Tyr His Ser Ala Gly Asn Ile Ile Gly Val Gly Gln Cys
     290                 295                 300

 ctc atc tat ggg ctg aca gtc gtc ctc cgc aag aaa ttc tcg gcc agc      960
 Leu Ile Tyr Gly Leu Thr Val Val Leu Arg Lys Lys Phe Ser Ala Ser
 305                 310                 315                 320

 cgc ttc tgg gac gac tgc atc aag tac aac tgc acg gtg gtt cag tac     1008
 Arg Phe Trp Asp Asp Cys Ile Lys Tyr Asn Cys Thr Val Val Gln Tyr
                 325                 330                 335

 atc ggg gag atc tgc cgc tac ctg ctg aag cag ccg gtg cgc gag gcg     1056
 Ile Gly Glu Ile Cys Arg Tyr Leu Leu Lys Gln Pro Val Arg Glu Ala
             340                 345                 350

 gag agg cga cac cgc gtg cgc ctg gcg gtg ggg aac ggg ctg cgt cct     1104
 Glu Arg Arg His Arg Val Arg Leu Ala Val Gly Asn Gly Leu Arg Pro
         355                 360                 365

 gcc atc tgg gag gag ttc acg gag cgc ttc ggc gta cgc caa atc ggg     1152
 Ala Ile Trp Glu Glu Phe Thr Glu Arg Phe Gly Val Arg Gln Ile Gly
     370                 375                 380

 gag ttc tac ggc gcc acc gag tgc aac tgc agc att gcc aac atg gac     1200
 Glu Phe Tyr Gly Ala Thr Glu Cys Asn Cys Ser Ile Ala Asn Met Asp
 385                 390                 395                 400

 ggc aag gtc ggc tcc tgt ggt ttc aac agc cgc atc ctg ccc cac gtg     1248
 Gly Lys Val Gly Ser Cys Gly Phe Asn Ser Arg Ile Leu Pro His Val
                 405                 410                 415

 tac ccc atc cgg ctg gtg aag gtc aat gag gac aca atg gag ctg ctg     1296
 Tyr Pro Ile Arg Leu Val Lys Val Asn Glu Asp Thr Met Glu Leu Leu
             420                 425                 430

 cgg gat gcc cag ggc ctc tgc atc ccc tgc cag gcc ggg gag cct ggc     1344
 Arg Asp Ala Gln Gly Leu Cys Ile Pro Cys Gln Ala Gly Glu Pro Gly
         435                 440                 445

 ctc ctt gtg ggt cag atc aac caa cag gac ccg ctg cgc cgc ttc gat     1392
 Leu Leu Val Gly Gln Ile Asn Gln Gln Asp Pro Leu Arg Arg Phe Asp
     450                 455                 460

 ggc tat gtc agc gag agc gcc acc agc aag aag atc gcc cac agc gtc     1440
 Gly Tyr Val Ser Glu Ser Ala Thr Ser Lys Lys Ile Ala His Ser Val
 465                 470                 475                 480

 ttc agc aag ggc gac agc gcc tac ctc tca ggt gac gtg cta gtg atg     1488
 Phe Ser Lys Gly Asp Ser Ala Tyr Leu Ser Gly Asp Val Leu Val Met
                 485                 490                 495

 gat gag ctg ggc tac atg tac ttc cgg gac cgt agc ggg gac acc ttc     1536
 Asp Glu Leu Gly Tyr Met Tyr Phe Arg Asp Arg Ser Gly Asp Thr Phe
             500                 505                 510

 cgc tgg cga ggg gag aac gtc tcc acc acc gag gtg gag ggc gtg ctg     1584
 Arg Trp Arg Gly Glu Asn Val Ser Thr Thr Glu Val Glu Gly Val Leu
         515                 520                 525

 agc cgc ctg ctg ggc cag aca gac gtg gcc gtc tat ggg gtg gct gtt     1632
 Ser Arg Leu Leu Gly Gln Thr Asp Val Ala Val Tyr Gly Val Ala Val
     530                 535                 540

 cca ggc aag ctg ggg ttg cag ggg gtg gtc ctg agg cat gga gtg gag     1680
 Pro Gly Lys Leu Gly Leu Gln Gly Val Val Leu Arg His Gly Val Glu
 545                 550                 555                 560

 ggt aag gca ggg atg gcg gcc gtc gca gac ccc cac agc ctg ctg gac     1728
 Gly Lys Ala Gly Met Ala Ala Val Ala Asp Pro His Ser Leu Leu Asp
                 565                 570                 575

 ccc aac gcg ata tac cag gag ctg cag aag gtg ctg gca ccc tat gcc     1776
 Pro Asn Ala Ile Tyr Gln Glu Leu Gln Lys Val Leu Ala Pro Tyr Ala
             580                 585                 590

 cgg ccc atc ttc ctg cgc ctc ctg ccc cag gtg gac acc aca ggc acc     1824
 Arg Pro Ile Phe Leu Arg Leu Leu Pro Gln Val Asp Thr Thr Gly Thr
         595                 600                 605

 ttc aag atc cag aag acg agg ctg cag cga gag ggc ttt gac cca cgc     1872
 Phe Lys Ile Gln Lys Thr Arg Leu Gln Arg Glu Gly Phe Asp Pro Arg
     610                 615                 620

 cag acc tca gac cgg ctc ttc ttc ctg gac ctg aag cag ggc cac tac     1920
 Gln Thr Ser Asp Arg Leu Phe Phe Leu Asp Leu Lys Gln Gly His Tyr
 625                 630                 635                 640

 ctg ccc tta aat gag gca gtc tac act cgc atc tgc tcg ggc gcc ttc     1968
 Leu Pro Leu Asn Glu Ala Val Tyr Thr Arg Ile Cys Ser Gly Ala Phe
                 645                 650                 655

 gcc ctc tga                                                         1977
 Ala Leu 






      <210> 543
      <211> 2055
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (159)..(788)

      <400> 543
 caaacccgcc cgctgagttg gtcgtttcgg aatcccgaga cttgaaaccc aacgggaaga     60

 cccttctcac cctcaaaaga agatgacagc ccgcagagag ttaacttctg tttacatgga    120

 actcagacat ctgcaaatca tgatttcaag gccagaga    atg gca ggg gaa cag     173
                                              Met Ala Gly Glu Gln
                                                1               5

 aaa ccc tca agt aat ctc ctg gag cag ttt att tta cta gcc aaa ggt      221
 Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile Leu Leu Ala Lys Gly
                  10                  15                  20

 acc agt ggc tca gcc ctc act gct ctc ata agc cag gtc tta gag gct      269
 Thr Ser Gly Ser Ala Leu Thr Ala Leu Ile Ser Gln Val Leu Glu Ala
              25                  30                  35

 ccc gga gtg tat gtc ttt gga gaa ctt ctg gag ctg gcc aac gtg cag      317
 Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu Leu Ala Asn Val Gln
          40                  45                  50

 gag tgt atc ccc tac tcc gtg ttg ctg aaa gac ctg gag atg cgg aat      365
 Glu Cys Ile Pro Tyr Ser Val Leu Leu Lys Asp Leu Glu Met Arg Asn
      55                  60                  65

 ctc cgg gaa cta gaa gac ctt atc att gag gct gtc tac act gac atc      413
 Leu Arg Glu Leu Glu Asp Leu Ile Ile Glu Ala Val Tyr Thr Asp Ile
  70                  75                  80                  85

 atc cag ggc aag ctg gac cag cga aac cag ctg ctg gaa gtg gat ttc      461
 Ile Gln Gly Lys Leu Asp Gln Arg Asn Gln Leu Leu Glu Val Asp Phe
                  90                  95                 100

 tgc att ggc cgt gac atc cga aag aag gat atc aat aat att gtc aag      509
 Cys Ile Gly Arg Asp Ile Arg Lys Lys Asp Ile Asn Asn Ile Val Lys
             105                 110                 115

 acc ctg cat gaa tgg tgt gat ggc tgt gaa gca gtt cta ctg ggc atc      557
 Thr Leu His Glu Trp Cys Asp Gly Cys Glu Ala Val Leu Leu Gly Ile
         120                 125                 130

 gag cag caa gtt ctg aga gcc aac cag tac aaa gag aac cac aac cga      605
 Glu Gln Gln Val Leu Arg Ala Asn Gln Tyr Lys Glu Asn His Asn Arg
     135                 140                 145

 act cag cag cag gta gaa gca gag gtt acc aac atc aag aag aca ctc      653
 Thr Gln Gln Gln Val Glu Ala Glu Val Thr Asn Ile Lys Lys Thr Leu
 150                 155                 160                 165

 aaa gcc acc gca tcc tcc tcg gct cag gag atg gag cag cag ctg gct      701
 Lys Ala Thr Ala Ser Ser Ser Ala Gln Glu Met Glu Gln Gln Leu Ala
                 170                 175                 180

 gaa cgg gag tgt ccc cct cac gct gag cag agg cag ccc acc aag aag      749
 Glu Arg Glu Cys Pro Pro His Ala Glu Gln Arg Gln Pro Thr Lys Lys
             185                 190                 195

 atg tcc aaa gtg aaa ggt ctg gtc tcc agc cgc cac tag ggccggctgg       798
 Met Ser Lys Val Lys Gly Leu Val Ser Ser Arg His 
         200                 205

 ggcagctggc actcaccagg cctgggtcag gtggggaggg gacaccaagg gcccatttcc    858

 tcccctctct acctgcagtg agttccagac ctgcccgtcc cctcaccagc gcctccccac    918

 cctgttggta ctgttccaga aaaactgtta ctccccctca cccactccct ccttccccag    978

 ttgttccctt cagactcagg ggctccacca atgccatccc aaaacagggt cagacactgc   1038

 ccagcttccc tccaggaggt tcttgtctct gtgtaagggc ttgtctccct cccagttttt   1098

 cttttgctcc acgtcatttt gtcaggctgg ttataagccg gaggcagctt taaccagccc   1158

 ccagggatga ttgtgaagga ggcccctccc cttgtgagga gggggcactc ctctccagcc   1218

 cctggtacca cagtcctcac gatggtgcag tgatttctag ccaggcgtca agatgcgctg   1278

 ctttccctct cctgcctcat cccttgttgg cagctccagt tcaggccgtg gagggacgtg   1338

 atgctgggct gtgtttacta aacccacggg ttttcagcct cttaagccca gctccgatct   1398

 ccaattagtt gagagcgctg ggttgactaa cctctggtat ctgagcacag acagagggtg   1458

 ctgtgggtct gctgggtggc agaaatggtt ccttccggct tggcgttctc tcctggccac   1518

 tcttcctgct gcctctgact actcagcctt gttttcggtg tgtaggcccc agctgcccac   1578

 tggaactgcc ggctaatgct tgctctccca agatctttaa ctcctcctgg ctgcacctgg   1638

 gtagggatgg tggcatcgat gcccctctgt ctgctgaagg acctgttgct gcttctgtct   1698

 tttcacccct ccttggctga tgacccagag ccctctgatg atggcattct cctggcaaga   1758

 gaaaaagact taactagact tctgaacttg aacagtttca ggttatattt taattttttt   1818

 ttttttgtac aggttctgat tctaatacat ttcaacatgc ttttgtcaaa aaaaaaaaaa   1878

 aaaaaaaaaa aaagaggggg gggaaaatat ccaggggcgc aattgtgccc cgctttgtag   1938

 agggcgcaag aggggaaaaa aagaaggggg ggaaagggcg ggaagaacgg cttggaggac   1998

 ctgggggagg ggaaccacga aagcgggaaa aagtgggcag ctggcgaggt aggaaat      2055




      <210> 544
      <211> 1007
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (183)..(800)

      <400> 544
 agtgacagca ggagtaagag tgggaggcag gacagagctg ggacacaggt atggagaggg     60

 ggttcagcga gcctagagag ggcagactat cagggtgccg gcggtgagaa tccagggaga    120

 ggagcggaaa cagaagaggg gcagaagacc ggggcacttg tgggttgcag agcccctcag    180

 cc   atg ttg gga gcc aag cca cac tgg cta cca ggt ccc cta cac agt     227
      Met Leu Gly Ala Lys Pro His Trp Leu Pro Gly Pro Leu His Ser
        1               5                  10                  15

 ccc ggg ctg ccc ttg gtt ctg gtg ctt ctg gcc ctg ggg gcc ggg tgg      275
 Pro Gly Leu Pro Leu Val Leu Val Leu Leu Ala Leu Gly Ala Gly Trp
                  20                  25                  30

 gcc cag gag ggg tca gag ccc gtc ctg ctg gag ggg gag tgc ctg gtg      323
 Ala Gln Glu Gly Ser Glu Pro Val Leu Leu Glu Gly Glu Cys Leu Val
              35                  40                  45

 gtc tgt gag cct ggc cga gct gct gca ggg ggg ccc ggg gga gca gcc      371
 Val Cys Glu Pro Gly Arg Ala Ala Ala Gly Gly Pro Gly Gly Ala Ala
          50                  55                  60

 ctg gga gag gca ccc cct ggg cga gtg gca ttt gct gcg gtc cga agc      419
 Leu Gly Glu Ala Pro Pro Gly Arg Val Ala Phe Ala Ala Val Arg Ser
      65                  70                  75

 cac cac cat gag cca gca ggg gaa acc ggc aat ggc acc agt ggg gcc      467
 His His His Glu Pro Ala Gly Glu Thr Gly Asn Gly Thr Ser Gly Ala
  80                  85                  90                  95

 atc tac ttc gac cag gtc ctg gtg aac gag ggc ggt ggc ttt gac cgg      515
 Ile Tyr Phe Asp Gln Val Leu Val Asn Glu Gly Gly Gly Phe Asp Arg
                 100                 105                 110

 gcc tct ggc tcc ttc gta gcc cct gtc cgg ggt gtc tac agc ttc cgg      563
 Ala Ser Gly Ser Phe Val Ala Pro Val Arg Gly Val Tyr Ser Phe Arg
             115                 120                 125

 ttc cat gtg gtg aag gtg tac aac cgc caa act gtc cag gtg agc ctg      611
 Phe His Val Val Lys Val Tyr Asn Arg Gln Thr Val Gln Val Ser Leu
         130                 135                 140

 gtg ctg aac acg tgg cct gtc atc tca gcc ttt gcc aat gat cct gac      659
 Val Leu Asn Thr Trp Pro Val Ile Ser Ala Phe Ala Asn Asp Pro Asp
     145                 150                 155

 gtg acc cgg gag gca gcc acc agc tct gtg cta ctg ccc ttg gac cct      707
 Val Thr Arg Glu Ala Ala Thr Ser Ser Val Leu Leu Pro Leu Asp Pro
 160                 165                 170                 175

 ggg gac cga gtg tct ctg cgc ctg cgt cgg ggg aat cta ctg ggt ggt      755
 Gly Asp Arg Val Ser Leu Arg Leu Arg Arg Gly Asn Leu Leu Gly Gly
                 180                 185                 190

 tgg aaa tac tca agt ttc tct ggc ttc ctc atc ttc cct ctc tga gga      803
 Trp Lys Tyr Ser Ser Phe Ser Gly Phe Leu Ile Phe Pro Leu 
             195                 200                 205

 cccaagtctt tcaagcacaa gaatccagcc cctgacaact ttcttctgcc ctctcttgcc    863

 ccagaaacag cagaggcagg agagagactc cctctggctc ctatcccacc tctttgcatg    923

 ggaccctgtg ccaaacaccc aagtttaaga gaagagtaga gctgtggcat ctccagacca    983

 ggcctttcca accacccctg tatt                                          1007




      <210> 545
      <211> 1635
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1635)

      <400> 545
  atg cga gag tct cag cct gaa gca gaa att cct ctc caa gac acc act      48
  Met Arg Glu Ser Gln Pro Glu Ala Glu Ile Pro Leu Gln Asp Thr Thr
    1               5                  10                  15

 gca gaa gca ttc aca atg cta ctc aaa tat atc tac act ggg cgg gca       96
 Ala Glu Ala Phe Thr Met Leu Leu Lys Tyr Ile Tyr Thr Gly Arg Ala
              20                  25                  30

 acg ctg aca gat gag aag gag gag gtg ctg ctg gac ttt ttg agc ctg      144
 Thr Leu Thr Asp Glu Lys Glu Glu Val Leu Leu Asp Phe Leu Ser Leu
          35                  40                  45

 gct cat aaa tat gga ttt cca gag cta gag gat tct acc tct gag tat      192
 Ala His Lys Tyr Gly Phe Pro Glu Leu Glu Asp Ser Thr Ser Glu Tyr
      50                  55                  60

 ctc tgc acc ata ctt aac att cag aat gtc tgc atg act ttt gat gtt      240
 Leu Cys Thr Ile Leu Asn Ile Gln Asn Val Cys Met Thr Phe Asp Val
  65                  70                  75                  80

 gcc agt ctc tac tca ctt ccc aag tta act tgt atg tgc tgc atg ttt      288
 Ala Ser Leu Tyr Ser Leu Pro Lys Leu Thr Cys Met Cys Cys Met Phe
                  85                  90                  95

 atg gat agg aat gct cag gaa gtc ctc tca agt gaa ggt ttc ctc tcc      336
 Met Asp Arg Asn Ala Gln Glu Val Leu Ser Ser Glu Gly Phe Leu Ser
             100                 105                 110

 ctt tct aag aca gca ctt tta aac atc gtg tta aga gac tca ttt gca      384
 Leu Ser Lys Thr Ala Leu Leu Asn Ile Val Leu Arg Asp Ser Phe Ala
         115                 120                 125

 gct ccc gaa aaa gat att ttc cta gcc tta tta aac tgg tgt aag cac      432
 Ala Pro Glu Lys Asp Ile Phe Leu Ala Leu Leu Asn Trp Cys Lys His
     130                 135                 140

 aat tca aag gag aat cat gct gaa atc atg cag gct gtg cgt tta cct      480
 Asn Ser Lys Glu Asn His Ala Glu Ile Met Gln Ala Val Arg Leu Pro
 145                 150                 155                 160

 ctc atg agc ctc aca gag ctt ctg aat gtt gtg agg cct tca gga ctg      528
 Leu Met Ser Leu Thr Glu Leu Leu Asn Val Val Arg Pro Ser Gly Leu
                 165                 170                 175

 ctg tct cct gat gcc atc ctg gat gcc att aaa gtg cga tct gag agc      576
 Leu Ser Pro Asp Ala Ile Leu Asp Ala Ile Lys Val Arg Ser Glu Ser
             180                 185                 190

 cgg gat atg gac ctc aat tat aga ggc atg ctc ata cca gaa gaa aac      624
 Arg Asp Met Asp Leu Asn Tyr Arg Gly Met Leu Ile Pro Glu Glu Asn
         195                 200                 205

 att gca act atg aag tat gga gcc caa gtt gta aag ggg gag ctg aaa      672
 Ile Ala Thr Met Lys Tyr Gly Ala Gln Val Val Lys Gly Glu Leu Lys
     210                 215                 220

 tca gcc tta tta gat ggt gat act caa aat tat gat ttg gat cat gga      720
 Ser Ala Leu Leu Asp Gly Asp Thr Gln Asn Tyr Asp Leu Asp His Gly
 225                 230                 235                 240

 ttt tca agg cac cca att gat gat gac tgc cgt tcc ggc atc gag att      768
 Phe Ser Arg His Pro Ile Asp Asp Asp Cys Arg Ser Gly Ile Glu Ile
                 245                 250                 255

 aag cta ggt cag cca tcc att atc aat cac gta cgg ata ctc ttg tgg      816
 Lys Leu Gly Gln Pro Ser Ile Ile Asn His Val Arg Ile Leu Leu Trp
             260                 265                 270

 gac cga gat agc cgg tct tac tca tac ttc att gaa gtg tca atg gat      864
 Asp Arg Asp Ser Arg Ser Tyr Ser Tyr Phe Ile Glu Val Ser Met Asp
         275                 280                 285

 gaa ctt gat tgg gtc aga gtg ata gat cat tca caa tat ctg tgt cgt      912
 Glu Leu Asp Trp Val Arg Val Ile Asp His Ser Gln Tyr Leu Cys Arg
     290                 295                 300

 tct tgg cag aaa tta tat ttt cca gcc cgt gtc tgc agg tat att cga      960
 Ser Trp Gln Lys Leu Tyr Phe Pro Ala Arg Val Cys Arg Tyr Ile Arg
 305                 310                 315                 320

 att gtt ggg act cac aac aca gtg aac aag att ttt cac att gtg gct     1008
 Ile Val Gly Thr His Asn Thr Val Asn Lys Ile Phe His Ile Val Ala
                 325                 330                 335

 ttt gaa tgt atg ttt aca aac aaa acc ttc act ctt gag aag ggg ctg     1056
 Phe Glu Cys Met Phe Thr Asn Lys Thr Phe Thr Leu Glu Lys Gly Leu
             340                 345                 350

 ata gtt ccc atg gag aat gtt gca aca att gct gat tgt gcc agt gtg     1104
 Ile Val Pro Met Glu Asn Val Ala Thr Ile Ala Asp Cys Ala Ser Val
         355                 360                 365

 att gaa gga gtc agt cgg agc cga aat gcc ttg ctg aat ggg gac act     1152
 Ile Glu Gly Val Ser Arg Ser Arg Asn Ala Leu Leu Asn Gly Asp Thr
     370                 375                 380

 aag aat tat gac tgg gat tct ggc tac aca tgt cac cag cta gga agt     1200
 Lys Asn Tyr Asp Trp Asp Ser Gly Tyr Thr Cys His Gln Leu Gly Ser
 385                 390                 395                 400

 ggt gcg att gtg gtt cag ttg gca caa ccg tac atg att ggg tca ata     1248
 Gly Ala Ile Val Val Gln Leu Ala Gln Pro Tyr Met Ile Gly Ser Ile
                 405                 410                 415

 cgg tta cta ctt tgg gat tgt gat gat cga agc tat agc tac tac gtt     1296
 Arg Leu Leu Leu Trp Asp Cys Asp Asp Arg Ser Tyr Ser Tyr Tyr Val
             420                 425                 430

 gag gtt tct acc aac cag caa cag tgg acc atg gtt gct gac aga act     1344
 Glu Val Ser Thr Asn Gln Gln Gln Trp Thr Met Val Ala Asp Arg Thr
         435                 440                 445

 aaa gtc tcc tgc aag tcc tgg cag tca gta act ttt gaa agg cag cct     1392
 Lys Val Ser Cys Lys Ser Trp Gln Ser Val Thr Phe Glu Arg Gln Pro
     450                 455                 460

 gcc tcc ttc atc cgt atc gtt ggg aca cac aac aca gca aat gag gtg     1440
 Ala Ser Phe Ile Arg Ile Val Gly Thr His Asn Thr Ala Asn Glu Val
 465                 470                 475                 480

 ttc cac tgt gtc cac ttt gag tgt cca gag cag cag agc agc cag aag     1488
 Phe His Cys Val His Phe Glu Cys Pro Glu Gln Gln Ser Ser Gln Lys
                 485                 490                 495

 gag gaa aat agt gag gaa tcg ggg aca ggg gac acc agc ctg gcc ggt     1536
 Glu Glu Asn Ser Glu Glu Ser Gly Thr Gly Asp Thr Ser Leu Ala Gly
             500                 505                 510

 cag cag ctc gac tcc cat gcg ctg cgg gcg cct agt ggc agc tca cta     1584
 Gln Gln Leu Asp Ser His Ala Leu Arg Ala Pro Ser Gly Ser Ser Leu
         515                 520                 525

 ccc tcc agc cca ggc tcc aac tca cgc tcc ccc aac cgg cag cac caa     1632
 Pro Ser Ser Pro Gly Ser Asn Ser Arg Ser Pro Asn Arg Gln His Gln
     530                 535                 540

 taa                                                                 1635
 






      <210> 546
      <211> 3357
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3357)

      <400> 546
  atg ggg atc ctc agc atc acg gac cag ccg ccc ctg gtc cag gcc atc      48
  Met Gly Ile Leu Ser Ile Thr Asp Gln Pro Pro Leu Val Gln Ala Ile
    1               5                  10                  15

 ttt agc cga gat gtg gag gaa gtg cgt tcc cta ctc tcg cag aag gag       96
 Phe Ser Arg Asp Val Glu Glu Val Arg Ser Leu Leu Ser Gln Lys Glu
              20                  25                  30

 aac atc aat gtg ctg gac caa gag agg cga act cca ttg cat gct gct      144
 Asn Ile Asn Val Leu Asp Gln Glu Arg Arg Thr Pro Leu His Ala Ala
          35                  40                  45

 gcc tac gta ggc gat gtc ccc atc ctc cag ttg cta ctg atg tca ggt      192
 Ala Tyr Val Gly Asp Val Pro Ile Leu Gln Leu Leu Leu Met Ser Gly
      50                  55                  60

 gaa agt ggg gag ctg gaa gga aat tat atc ccc aca ggt gct aat gtc      240
 Glu Ser Gly Glu Leu Glu Gly Asn Tyr Ile Pro Thr Gly Ala Asn Val
  65                  70                  75                  80

 aat gct aag gac aca ctg tgg ctg acc cct ctt cat cgt gct gct gcc      288
 Asn Ala Lys Asp Thr Leu Trp Leu Thr Pro Leu His Arg Ala Ala Ala
                  85                  90                  95

 tcc cga aac gag gta tgc acc ccc acc ttc tat tac cct ttc aaa aag      336
 Ser Arg Asn Glu Val Cys Thr Pro Thr Phe Tyr Tyr Pro Phe Lys Lys
             100                 105                 110

 gat aag ttg ctt aaa gca cca ggg gga ggg gcc gag gcc agt ggg aat      384
 Asp Lys Leu Leu Lys Ala Pro Gly Gly Gly Ala Glu Ala Ser Gly Asn
         115                 120                 125

 gag aag gtg ctg ggg ctg ctg ctg gca cat tca gca gat gtg aat gcc      432
 Glu Lys Val Leu Gly Leu Leu Leu Ala His Ser Ala Asp Val Asn Ala
     130                 135                 140

 cgg gac aag ctg tgg cag aca cca ctg cat gtg gct gct gcc aac cgg      480
 Arg Asp Lys Leu Trp Gln Thr Pro Leu His Val Ala Ala Ala Asn Arg
 145                 150                 155                 160

 gcc acc aag tgt gct gag gct ctg gca ccc ctg ttg agc agc ctc aac      528
 Ala Thr Lys Cys Ala Glu Ala Leu Ala Pro Leu Leu Ser Ser Leu Asn
                 165                 170                 175

 gtg gct gac agg agc ggg cgc agt gct ctg cac cat gca gtg cat agt      576
 Val Ala Asp Arg Ser Gly Arg Ser Ala Leu His His Ala Val His Ser
             180                 185                 190

 ggg cat ctt gag acg gtg aac ctg ctc ctc aac aag gga gcc agc ctg      624
 Gly His Leu Glu Thr Val Asn Leu Leu Leu Asn Lys Gly Ala Ser Leu
         195                 200                 205

 aat gtc tgt gac aaa aag gag cgg cag cct ctg cat tgg gca gct ttt      672
 Asn Val Cys Asp Lys Lys Glu Arg Gln Pro Leu His Trp Ala Ala Phe
     210                 215                 220

 cta ggg cac ttg gag gtc cta aaa ctg ctg gtg gca cgg gga gca gac      720
 Leu Gly His Leu Glu Val Leu Lys Leu Leu Val Ala Arg Gly Ala Asp
 225                 230                 235                 240

 ctc ggc tgc aag gac cgc aag ggc tat ggg ctg ctc cat aca gct gct      768
 Leu Gly Cys Lys Asp Arg Lys Gly Tyr Gly Leu Leu His Thr Ala Ala
                 245                 250                 255

 gcc agt ggc cag att gaa gtg gtg aag tac ctg ctt cgg atg gga gcg      816
 Ala Ser Gly Gln Ile Glu Val Val Lys Tyr Leu Leu Arg Met Gly Ala
             260                 265                 270

 gag atc gat gaa ccc aat gct ttt gga aac aca gct ttg cac atc gcc      864
 Glu Ile Asp Glu Pro Asn Ala Phe Gly Asn Thr Ala Leu His Ile Ala
         275                 280                 285

 tgc tac ctg ggc cag gat gct gtg gct att gag ctg gtg aat gcc gga      912
 Cys Tyr Leu Gly Gln Asp Ala Val Ala Ile Glu Leu Val Asn Ala Gly
     290                 295                 300

 gcc aat gtc aac cag ccg aat gac aag ggc ttc acg cca ctg cat gtg      960
 Ala Asn Val Asn Gln Pro Asn Asp Lys Gly Phe Thr Pro Leu His Val
 305                 310                 315                 320

 gct gca gtc tcc acc aat gtt gct ctc tgc ttg gag cta ctg gtt aat     1008
 Ala Ala Val Ser Thr Asn Val Ala Leu Cys Leu Glu Leu Leu Val Asn
                 325                 330                 335

 aat ggg gct gac gtc aac tac cag agc aaa gaa ggg aaa agt cct ctg     1056
 Asn Gly Ala Asp Val Asn Tyr Gln Ser Lys Glu Gly Lys Ser Pro Leu
             340                 345                 350

 cac atg gct gca atc cat ggc cgt ttc aca cgc tcc cag atc ctc atc     1104
 His Met Ala Ala Ile His Gly Arg Phe Thr Arg Ser Gln Ile Leu Ile
         355                 360                 365

 cag aat ggc agc gag att gat tgt gcc gac aaa ttt ggg aac acg cca     1152
 Gln Asn Gly Ser Glu Ile Asp Cys Ala Asp Lys Phe Gly Asn Thr Pro
     370                 375                 380

 ctg cat gtg gct gct cga tat gga cac gag ctg ctc atc agc acc ctc     1200
 Leu His Val Ala Ala Arg Tyr Gly His Glu Leu Leu Ile Ser Thr Leu
 385                 390                 395                 400

 atg acc aat ggc gca gat acc gcc cgg cgt ggc atc cat gac atg ttc     1248
 Met Thr Asn Gly Ala Asp Thr Ala Arg Arg Gly Ile His Asp Met Phe
                 405                 410                 415

 ccc ctg cac tta gct gtt ctc ttt gga ttc tct gac tgt tgt cgt aag     1296
 Pro Leu His Leu Ala Val Leu Phe Gly Phe Ser Asp Cys Cys Arg Lys
             420                 425                 430

 ctt ctt tcc tca ggt cag ttg tac agc att gtg tct tca ctc agc aat     1344
 Leu Leu Ser Ser Gly Gln Leu Tyr Ser Ile Val Ser Ser Leu Ser Asn
         435                 440                 445

 gag cat gtg ctt tca gct ggg ttt gac atc aat aca cct gac aac ctt     1392
 Glu His Val Leu Ser Ala Gly Phe Asp Ile Asn Thr Pro Asp Asn Leu
     450                 455                 460

 ggc cgt acc tgt ctt cat gct gct gct tcc gga ggg aat gtt gaa tgt     1440
 Gly Arg Thr Cys Leu His Ala Ala Ala Ser Gly Gly Asn Val Glu Cys
 465                 470                 475                 480

 ctt aat ttg ctg ttg agc agt gga gct gac ttg agg agg agg gac aaa     1488
 Leu Asn Leu Leu Leu Ser Ser Gly Ala Asp Leu Arg Arg Arg Asp Lys
                 485                 490                 495

 ttt ggc agg acc cca ctg cac tat gca gct gct aac ggt agc tac cag     1536
 Phe Gly Arg Thr Pro Leu His Tyr Ala Ala Ala Asn Gly Ser Tyr Gln
             500                 505                 510

 tgt gca gta aca ttg gtg act gct ggg gca ggt gtc aac gag gcc gac     1584
 Cys Ala Val Thr Leu Val Thr Ala Gly Ala Gly Val Asn Glu Ala Asp
         515                 520                 525

 tgt aaa ggc tgc tct ccc ctc cac tac gct gcc gct tct gac act tac     1632
 Cys Lys Gly Cys Ser Pro Leu His Tyr Ala Ala Ala Ser Asp Thr Tyr
     530                 535                 540

 agg aga gcg gaa ccc cat aca cct tcc agc cat gat gcc gaa gag gac     1680
 Arg Arg Ala Glu Pro His Thr Pro Ser Ser His Asp Ala Glu Glu Asp
 545                 550                 555                 560

 gag cca ctg aag gag tcc cgc agg aag gag gcc ttc ttc tgt ctg gag     1728
 Glu Pro Leu Lys Glu Ser Arg Arg Lys Glu Ala Phe Phe Cys Leu Glu
                 565                 570                 575

 ttc tta ctg gat aac ggt gca gac ccc tcc ctg cgg gac agg cag ggc     1776
 Phe Leu Leu Asp Asn Gly Ala Asp Pro Ser Leu Arg Asp Arg Gln Gly
             580                 585                 590

 tac aca gct gtg cac tat gca gcc gcc tat ggc aac aga cag aac ctc     1824
 Tyr Thr Ala Val His Tyr Ala Ala Ala Tyr Gly Asn Arg Gln Asn Leu
         595                 600                 605

 gaa ctg ctc tta gaa atg tcc ttt aac tgc ctg gag gat gtg gag agc     1872
 Glu Leu Leu Leu Glu Met Ser Phe Asn Cys Leu Glu Asp Val Glu Ser
     610                 615                 620

 acc att cca gtc agc cct ttg cac tta gct gcc tac aac ggt cac tgt     1920
 Thr Ile Pro Val Ser Pro Leu His Leu Ala Ala Tyr Asn Gly His Cys
 625                 630                 635                 640

 gaa gcc ttg aag acg ctg gcg gag acg ctg gtg aat ctg gac gta agg     1968
 Glu Ala Leu Lys Thr Leu Ala Glu Thr Leu Val Asn Leu Asp Val Arg
                 645                 650                 655

 gac cac aag ggc cgg acc gca ctc ttc ctg gcc acg gag cgc ggc tct     2016
 Asp His Lys Gly Arg Thr Ala Leu Phe Leu Ala Thr Glu Arg Gly Ser
             660                 665                 670

 act gag tgt gtg gag gtg ctt aca gcc cac ggc gcc tct gcc ctc atc     2064
 Thr Glu Cys Val Glu Val Leu Thr Ala His Gly Ala Ser Ala Leu Ile
         675                 680                 685

 aag gag cgc aag cgc aag tgg aca ccc ctg cac gct gct gct gcc tct     2112
 Lys Glu Arg Lys Arg Lys Trp Thr Pro Leu His Ala Ala Ala Ala Ser
     690                 695                 700

 ggc cac act gac tcc ctg cac ttg ctg atc gac agt ggg gaa cga gct     2160
 Gly His Thr Asp Ser Leu His Leu Leu Ile Asp Ser Gly Glu Arg Ala
 705                 710                 715                 720

 gac atc aca gat gtc atg gat gcc tat gga cag acc cca ctg atg ctg     2208
 Asp Ile Thr Asp Val Met Asp Ala Tyr Gly Gln Thr Pro Leu Met Leu
                 725                 730                 735

 gcc atc atg aat ggc cat gtg gac tgt gta cat ctg ctg cta gag aaa     2256
 Ala Ile Met Asn Gly His Val Asp Cys Val His Leu Leu Leu Glu Lys
             740                 745                 750

 gga tcc aca gct gat gct gct gac ctc cgg ggc cgc act gcc ctc cac     2304
 Gly Ser Thr Ala Asp Ala Ala Asp Leu Arg Gly Arg Thr Ala Leu His
         755                 760                 765

 cgc ggg gca gtg act ggc tgt gag gac tgc ctg gct gcc ctg ctg gac     2352
 Arg Gly Ala Val Thr Gly Cys Glu Asp Cys Leu Ala Ala Leu Leu Asp
     770                 775                 780

 cac gac gca ttt gtg ctg tgc cga gac ttt aag ggc cgc acg ccc att     2400
 His Asp Ala Phe Val Leu Cys Arg Asp Phe Lys Gly Arg Thr Pro Ile
 785                 790                 795                 800

 cac ctg gcc tca gcc tgt ggc cac act gca gta ctg cgg acc ctg ctg     2448
 His Leu Ala Ser Ala Cys Gly His Thr Ala Val Leu Arg Thr Leu Leu
                 805                 810                 815

 cag gct gcc ctt tcc aca gat ccc ctg gat gcc ggg gtg gat tac agc     2496
 Gln Ala Ala Leu Ser Thr Asp Pro Leu Asp Ala Gly Val Asp Tyr Ser
             820                 825                 830

 gga tac tcg ccc atg cac tgg gcc tcc tac act gga cat gaa gat tgt     2544
 Gly Tyr Ser Pro Met His Trp Ala Ser Tyr Thr Gly His Glu Asp Cys
         835                 840                 845

 ctg gag ttg tta ctt gaa cac agc ccg ttt tcg tac ctg gaa gga aac     2592
 Leu Glu Leu Leu Leu Glu His Ser Pro Phe Ser Tyr Leu Glu Gly Asn
     850                 855                 860

 ccc ttc act cct ttg cac tgt gca gtg att aat aac caa gac agc acc     2640
 Pro Phe Thr Pro Leu His Cys Ala Val Ile Asn Asn Gln Asp Ser Thr
 865                 870                 875                 880

 aca gag atg cta ctg gga gct ctg ggt gcc aag att gtg aac agc cga     2688
 Thr Glu Met Leu Leu Gly Ala Leu Gly Ala Lys Ile Val Asn Ser Arg
                 885                 890                 895

 gat gcc aaa gga cgg acc ccc ctt cac gcc gct gcc ttc gcg gac aat     2736
 Asp Ala Lys Gly Arg Thr Pro Leu His Ala Ala Ala Phe Ala Asp Asn
             900                 905                 910

 gtc tct ggg ctc cgg atg ctg ctg cag cat caa gct gag gtg aac gcc     2784
 Val Ser Gly Leu Arg Met Leu Leu Gln His Gln Ala Glu Val Asn Ala
         915                 920                 925

 act gac cac act ggc cgc act gcg ctc atg acg gcg gct gag aac ggg     2832
 Thr Asp His Thr Gly Arg Thr Ala Leu Met Thr Ala Ala Glu Asn Gly
     930                 935                 940

 cag acc gct gct gtg gaa ttt ctg ctg tat cga ggg aag gca gac ctt     2880
 Gln Thr Ala Ala Val Glu Phe Leu Leu Tyr Arg Gly Lys Ala Asp Leu
 945                 950                 955                 960

 act gtg ttg gat gag aac aag aac acg gcc ctc cac ttg gct tgt agc     2928
 Thr Val Leu Asp Glu Asn Lys Asn Thr Ala Leu His Leu Ala Cys Ser
                 965                 970                 975

 aag ggc cat gag aaa tgt gcc ctc atg atc ctg gca gaa acc caa gac     2976
 Lys Gly His Glu Lys Cys Ala Leu Met Ile Leu Ala Glu Thr Gln Asp
             980                 985                 990

 ctt ggc ctt atc aat gct acc aac agt gcg ctg cag atg cca ctc cac     3024
 Leu Gly Leu Ile Asn Ala Thr Asn Ser Ala Leu Gln Met Pro Leu His
         995                1000                1005

 att gct gcc cgg aat ggt cta gct tct gtg gta cag gcc ctg ctg agt     3072
 Ile Ala Ala Arg Asn Gly Leu Ala Ser Val Val Gln Ala Leu Leu Ser
    1010                1015                1020

 cat ggg gcc aca gtg ctg gct gtg gat gaa gaa ggt cac acc cca gca     3120
 His Gly Ala Thr Val Leu Ala Val Asp Glu Glu Gly His Thr Pro Ala
1025                1030                1035                1040

 ctg gcc tgt gcc ccc aac aaa gat gtg gca gac tgc ctg gcc ttg atc     3168
 Leu Ala Cys Ala Pro Asn Lys Asp Val Ala Asp Cys Leu Ala Leu Ile
                1045                1050                1055

 ctt tcc acc atg aag cct ttc cca ccc aag gac gcc gtc agt cct ttc     3216
 Leu Ser Thr Met Lys Pro Phe Pro Pro Lys Asp Ala Val Ser Pro Phe
            1060                1065                1070

 agc ttc agc ctg ctc aag aac tgc agc att gca gcc gcc aag acg gtg     3264
 Ser Phe Ser Leu Leu Lys Asn Cys Ser Ile Ala Ala Ala Lys Thr Val
        1075                1080                1085

 ggt ggc tgc ggc gcc ctg ccc cat ggg gcc tcc tgc ccc tac agc cag     3312
 Gly Gly Cys Gly Ala Leu Pro His Gly Ala Ser Cys Pro Tyr Ser Gln
    1090                1095                1100

 gag cgg ccc ggc gcc att ggg tta gat ggc tgc tac tct gag tag         3357
 Glu Arg Pro Gly Ala Ile Gly Leu Asp Gly Cys Tyr Ser Glu 
1105                1110                1115





      <210> 547
      <211> 1750
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(1524)

      <400> 547
 ttgaggacac cttgattaac ctccaagggc aactaaagga tcaagaaagg cccagcacag     60

 cagaagatca gctggatcta gctcctgcag gag atg tgt aca aag aca atc cca     114
                                      Met Cys Thr Lys Thr Ile Pro
                                        1               5

 gtc ctc tgg gga tgt ttc ctc ctg tgg aat ctc tat gtc tca tcc tct      162
 Val Leu Trp Gly Cys Phe Leu Leu Trp Asn Leu Tyr Val Ser Ser Ser
          10                  15                  20

 cag acc att tac cct gga atc aag gca agg att act cag agg gca ctt      210
 Gln Thr Ile Tyr Pro Gly Ile Lys Ala Arg Ile Thr Gln Arg Ala Leu
      25                  30                  35

 gac tat ggt gtt caa gct gga atg aag atg att gag caa atg cta aaa      258
 Asp Tyr Gly Val Gln Ala Gly Met Lys Met Ile Glu Gln Met Leu Lys
  40                  45                  50                  55

 gaa aag aaa ctc cca gat tta agc ggt tct gag tct ctt gaa ttt cta      306
 Glu Lys Lys Leu Pro Asp Leu Ser Gly Ser Glu Ser Leu Glu Phe Leu
                  60                  65                  70

 aaa gtt gat tat gta aac tac aat ttt tca aat ata aaa atc agt gcc      354
 Lys Val Asp Tyr Val Asn Tyr Asn Phe Ser Asn Ile Lys Ile Ser Ala
              75                  80                  85

 ttt tca ttt cca aat acc tca ttg gct ttt gtg cct gga gtg gga atc      402
 Phe Ser Phe Pro Asn Thr Ser Leu Ala Phe Val Pro Gly Val Gly Ile
          90                  95                 100

 aaa gcg cta acc aac cat ggc act gcc aac atc agc aca gac tgg ggg      450
 Lys Ala Leu Thr Asn His Gly Thr Ala Asn Ile Ser Thr Asp Trp Gly
     105                 110                 115

 ttc gag tct cca ctt ttc caa gac aca gga ggg gct gat ctg ttt ctc      498
 Phe Glu Ser Pro Leu Phe Gln Asp Thr Gly Gly Ala Asp Leu Phe Leu
 120                 125                 130                 135

 tcc gga gtc tac ttt acc ggt atc att atc cta acc cga aat gac ttt      546
 Ser Gly Val Tyr Phe Thr Gly Ile Ile Ile Leu Thr Arg Asn Asp Phe
                 140                 145                 150

 ggt cat cct acc ctg aag ctc caa gat tgc tac gcc caa ctg agc cat      594
 Gly His Pro Thr Leu Lys Leu Gln Asp Cys Tyr Ala Gln Leu Ser His
             155                 160                 165

 gcc cac gtc tca ttt tcc gga gaa ctc agt gtt ctg tat aac tcc ttt      642
 Ala His Val Ser Phe Ser Gly Glu Leu Ser Val Leu Tyr Asn Ser Phe
         170                 175                 180

 gct gag ccc atg gag aaa ccc att tta aag aac tta aat gaa atg ctc      690
 Ala Glu Pro Met Glu Lys Pro Ile Leu Lys Asn Leu Asn Glu Met Leu
     185                 190                 195

 tgt ccc att att gca agt gaa gtc aaa gcg cta aat gcc aac ctc agc      738
 Cys Pro Ile Ile Ala Ser Glu Val Lys Ala Leu Asn Ala Asn Leu Ser
 200                 205                 210                 215

 aca ctg gag gtt tta acc aag att gac aac tac act ctg ctg gat tac      786
 Thr Leu Glu Val Leu Thr Lys Ile Asp Asn Tyr Thr Leu Leu Asp Tyr
                 220                 225                 230

 tcc cta atc agt tct cca gaa att act gag aac tac ctt gac ctg aac      834
 Ser Leu Ile Ser Ser Pro Glu Ile Thr Glu Asn Tyr Leu Asp Leu Asn
             235                 240                 245

 ttg aag ggt gta ttc tac cca ctg gaa aac ctc acc gac ccc ccc ttc      882
 Leu Lys Gly Val Phe Tyr Pro Leu Glu Asn Leu Thr Asp Pro Pro Phe
         250                 255                 260

 tca cca gtt cct ttt gtg ctc cca gaa cgc agc aac tcc atg ctc tac      930
 Ser Pro Val Pro Phe Val Leu Pro Glu Arg Ser Asn Ser Met Leu Tyr
     265                 270                 275

 att gga atc gcc gag tat ttc ttt aaa tct gcg tcc ttt gct cat ttc      978
 Ile Gly Ile Ala Glu Tyr Phe Phe Lys Ser Ala Ser Phe Ala His Phe
 280                 285                 290                 295

 aca gct ggg gtt ttc aat gtc act ctc tcc acc gaa gag att tcc aac     1026
 Thr Ala Gly Val Phe Asn Val Thr Leu Ser Thr Glu Glu Ile Ser Asn
                 300                 305                 310

 cat ttt gtt caa aac tct caa ggc ctt ggc aac gtg ctc tcc cgg att     1074
 His Phe Val Gln Asn Ser Gln Gly Leu Gly Asn Val Leu Ser Arg Ile
             315                 320                 325

 gca gag atc tac atc ttg tcc cag ccc ttc atg gtg agg atc atg gcc     1122
 Ala Glu Ile Tyr Ile Leu Ser Gln Pro Phe Met Val Arg Ile Met Ala
         330                 335                 340

 aca gag cct ccc ata atc aat cta caa cca ggc aat ttc acc ctg gac     1170
 Thr Glu Pro Pro Ile Ile Asn Leu Gln Pro Gly Asn Phe Thr Leu Asp
     345                 350                 355

 atc cct gcc tcc atc atg atg ctc acc caa ccc aag aac tcc aca gtt     1218
 Ile Pro Ala Ser Ile Met Met Leu Thr Gln Pro Lys Asn Ser Thr Val
 360                 365                 370                 375

 gaa acc atc gtt tcc atg gac ttc gtt gct agt acc agt gtt ggc ctg     1266
 Glu Thr Ile Val Ser Met Asp Phe Val Ala Ser Thr Ser Val Gly Leu
                 380                 385                 390

 gtt att ttg gga caa aga ctg gtc tgc tcc ttg tct ctg aac aga ttc     1314
 Val Ile Leu Gly Gln Arg Leu Val Cys Ser Leu Ser Leu Asn Arg Phe
             395                 400                 405

 cgc ctt gct ttg cca gag tcc aat cgc agc aac att gag gtc ttg agg     1362
 Arg Leu Ala Leu Pro Glu Ser Asn Arg Ser Asn Ile Glu Val Leu Arg
         410                 415                 420

 ttt gaa aat att cta tcg tcc att ctt cac ttt gga gtc ctc cca ctg     1410
 Phe Glu Asn Ile Leu Ser Ser Ile Leu His Phe Gly Val Leu Pro Leu
     425                 430                 435

 gcc aat gca aaa ttg cag caa gga ttt cct ctg ccc aat cca cac aaa     1458
 Ala Asn Ala Lys Leu Gln Gln Gly Phe Pro Leu Pro Asn Pro His Lys
 440                 445                 450                 455

 ttc tta ttc gtc aat tca gat att gaa gtt ctt gag gta aga atg caa     1506
 Phe Leu Phe Val Asn Ser Asp Ile Glu Val Leu Glu Val Arg Met Gln
                 460                 465                 470

 atc tca cct ctt aac tga cccatt tctttttata gtagactaag cctcctcctg     1560
 Ile Ser Pro Leu Asn 
             475

 ttttgcttgt ttttgttgtt gttgtttgtt tttgtcctgc tttgcttttt cccagaccag   1620

 ggaatcttat aaacatgttt agttcttaaa tcacaattaa cagaaaatat ttagagttga   1680

 gtctaaaaat cagaccaaga tcaatttcac ttagcagcca aatccacagt ataagaagat   1740

 gccccttagc                                                          1750




      <210> 548
      <211> 1750
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(1524)

      <400> 548
 ttgaggacac cttgattaac ctccaagggc aactaaagga tcaagaaagg cccagcacag     60

 cagaagatca gctggatcta gctcctgcag gag atg tgt aca aag aca atc cca     114
                                      Met Cys Thr Lys Thr Ile Pro
                                        1               5

 gtc ctc tgg gga tgt ttc ctc ctg tgg aat ctc tat gtc tca tcc tct      162
 Val Leu Trp Gly Cys Phe Leu Leu Trp Asn Leu Tyr Val Ser Ser Ser
          10                  15                  20

 cag acc att tac cct gga atc aag gca agg att act cag agg gca ctt      210
 Gln Thr Ile Tyr Pro Gly Ile Lys Ala Arg Ile Thr Gln Arg Ala Leu
      25                  30                  35

 gac tat ggt gtt caa gct gga atg aag atg att gag caa atg cta aaa      258
 Asp Tyr Gly Val Gln Ala Gly Met Lys Met Ile Glu Gln Met Leu Lys
  40                  45                  50                  55

 gaa aag aaa ctc cca gat tta agc ggt tct gag tct ctt gaa ttt cta      306
 Glu Lys Lys Leu Pro Asp Leu Ser Gly Ser Glu Ser Leu Glu Phe Leu
                  60                  65                  70

 aaa gtt gat tat gta aac tac aat ttt tca aat ata aaa atc agt gcc      354
 Lys Val Asp Tyr Val Asn Tyr Asn Phe Ser Asn Ile Lys Ile Ser Ala
              75                  80                  85

 ttt tca ttt cca aat acc tca ttg gct ttt gtg cct gga gtg gga atc      402
 Phe Ser Phe Pro Asn Thr Ser Leu Ala Phe Val Pro Gly Val Gly Ile
          90                  95                 100

 aaa gcg cta acc aac cat ggc act gcc aac atc agc aca gac tgg ggg      450
 Lys Ala Leu Thr Asn His Gly Thr Ala Asn Ile Ser Thr Asp Trp Gly
     105                 110                 115

 ttc gag tct cca ctt ttc caa gac aca gga ggg gct gat ctg ttt ctc      498
 Phe Glu Ser Pro Leu Phe Gln Asp Thr Gly Gly Ala Asp Leu Phe Leu
 120                 125                 130                 135

 tcc gga gtc tac ttt acc ggt atc att atc cta acc cga aat gac ttt      546
 Ser Gly Val Tyr Phe Thr Gly Ile Ile Ile Leu Thr Arg Asn Asp Phe
                 140                 145                 150

 ggt cat cct acc ctg aag ctc caa gat tgc tac gcc caa ctg agc cat      594
 Gly His Pro Thr Leu Lys Leu Gln Asp Cys Tyr Ala Gln Leu Ser His
             155                 160                 165

 gcc cac gtc tca ttt tcc gga gaa ctc agt gtt ctg tat aac tcc ttt      642
 Ala His Val Ser Phe Ser Gly Glu Leu Ser Val Leu Tyr Asn Ser Phe
         170                 175                 180

 gct gag ccc atg gag aaa ccc att tta aag aac tta aat gaa atg ctc      690
 Ala Glu Pro Met Glu Lys Pro Ile Leu Lys Asn Leu Asn Glu Met Leu
     185                 190                 195

 tgt ccc att att gca agt gaa gtc aaa gcg cta aat gcc aac ctc agc      738
 Cys Pro Ile Ile Ala Ser Glu Val Lys Ala Leu Asn Ala Asn Leu Ser
 200                 205                 210                 215

 aca ctg gag gtt tta acc aag att gac aac tac act ctg ctg gat tac      786
 Thr Leu Glu Val Leu Thr Lys Ile Asp Asn Tyr Thr Leu Leu Asp Tyr
                 220                 225                 230

 tcc cta atc agt tct cca gaa att act gag aac tac ctt gac ctg aac      834
 Ser Leu Ile Ser Ser Pro Glu Ile Thr Glu Asn Tyr Leu Asp Leu Asn
             235                 240                 245

 ttg aag ggt gta ttc tac cca ctg gaa aac ctc acc gac ccc ccc ttc      882
 Leu Lys Gly Val Phe Tyr Pro Leu Glu Asn Leu Thr Asp Pro Pro Phe
         250                 255                 260

 tca cca gtt cct ttt gtg ctc cca gaa cgc agc aac tcc atg ctc tac      930
 Ser Pro Val Pro Phe Val Leu Pro Glu Arg Ser Asn Ser Met Leu Tyr
     265                 270                 275

 att gga atc gcc gag tat ttc ttt aaa tct gcg tcc ttt gct cat ttc      978
 Ile Gly Ile Ala Glu Tyr Phe Phe Lys Ser Ala Ser Phe Ala His Phe
 280                 285                 290                 295

 aca gct ggg gtt ttc aat gtc act ctc tcc acc gaa gag att tcc aac     1026
 Thr Ala Gly Val Phe Asn Val Thr Leu Ser Thr Glu Glu Ile Ser Asn
                 300                 305                 310

 cat ttt gtt caa aac tct caa ggc ctt ggc aac gtg ctc tcc cgg att     1074
 His Phe Val Gln Asn Ser Gln Gly Leu Gly Asn Val Leu Ser Arg Ile
             315                 320                 325

 gca gag atc tac atc ttg tcc cag ccc ttc atg gtg agg atc atg gcc     1122
 Ala Glu Ile Tyr Ile Leu Ser Gln Pro Phe Met Val Arg Ile Met Ala
         330                 335                 340

 aca gag cct ccc ata atc aat cta caa cca ggc aat ttc acc ctg gac     1170
 Thr Glu Pro Pro Ile Ile Asn Leu Gln Pro Gly Asn Phe Thr Leu Asp
     345                 350                 355

 atc cct gcc tcc atc atg atg ctc acc caa ccc aag aac tcc aca gtt     1218
 Ile Pro Ala Ser Ile Met Met Leu Thr Gln Pro Lys Asn Ser Thr Val
 360                 365                 370                 375

 gaa acc atc gtt tcc atg gac ttc gtt gct agt acc agt gtt ggc ctg     1266
 Glu Thr Ile Val Ser Met Asp Phe Val Ala Ser Thr Ser Val Gly Leu
                 380                 385                 390

 gtt att ttg gga caa aga ctg gtc tgc tcc ttg tct ctg aac aga ttc     1314
 Val Ile Leu Gly Gln Arg Leu Val Cys Ser Leu Ser Leu Asn Arg Phe
             395                 400                 405

 cgc ctt gct ttg cca gag tcc aat cgc agc aac att gag gtc ttg agg     1362
 Arg Leu Ala Leu Pro Glu Ser Asn Arg Ser Asn Ile Glu Val Leu Arg
         410                 415                 420

 ttt gaa aat att cta tcg tcc att ctt cac ttt gga gtc ctc cca ctg     1410
 Phe Glu Asn Ile Leu Ser Ser Ile Leu His Phe Gly Val Leu Pro Leu
     425                 430                 435

 gcc aat gca aaa ttg cag caa gga ttt cct ctg tcc aat cca cac aaa     1458
 Ala Asn Ala Lys Leu Gln Gln Gly Phe Pro Leu Ser Asn Pro His Lys
 440                 445                 450                 455

 ttc tta ttc gtc aat tca gat att gaa gtt ctt gag gta aga atg caa     1506
 Phe Leu Phe Val Asn Ser Asp Ile Glu Val Leu Glu Val Arg Met Gln
                 460                 465                 470

 atc tca cct ctt aac tga cccatt tctttttata gtagactaag cctcctcctg     1560
 Ile Ser Pro Leu Asn 
             475

 ttttgcttgt ttttgttgtt gttgtttgtt tttgtcctgc tttgcttttt cccagaccag   1620

 ggaatcttat aaacatgttt agttcttaaa tcacaattaa cagaaaatat ttagagttga   1680

 gtctaaaaat cagaccaaga tcaatttcac ttagcagcca aatccacagt ataagaagat   1740

 gccccttagc                                                          1750




      <210> 549
      <211> 2070
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(1617)

      <220>
      <221> misc_feature
      <222> (1)...(2070)
      <223> n = a,t,c or g

      <400> 549
 ttgaggacac cttgattaac ctccaagggc aactaaagga tcaagaaagg cccagcacag     60

 cagaagatca gctggatcta gctcctgcag gag atg tgt aca aag aca atc cca     114
                                      Met Cys Thr Lys Thr Ile Pro
                                        1               5

 gtc ctc tgg gga tgt ttc ctc ctg tgg aat ctc tat gtc tca tcc tct      162
 Val Leu Trp Gly Cys Phe Leu Leu Trp Asn Leu Tyr Val Ser Ser Ser
          10                  15                  20

 cag acc att tac cct gga atc aag gca agg att act cag agg gca ctt      210
 Gln Thr Ile Tyr Pro Gly Ile Lys Ala Arg Ile Thr Gln Arg Ala Leu
      25                  30                  35

 gac tat ggt gtt caa gct gga atg aag atg att gag caa atg cta aaa      258
 Asp Tyr Gly Val Gln Ala Gly Met Lys Met Ile Glu Gln Met Leu Lys
  40                  45                  50                  55

 gaa aag aaa ctc cca gat tta agc ggt tct gag tct ctt gaa ttt cta      306
 Glu Lys Lys Leu Pro Asp Leu Ser Gly Ser Glu Ser Leu Glu Phe Leu
                  60                  65                  70

 aaa gtt gat tat gta aac tac aat ttt tca aat ata aaa atc agt gcc      354
 Lys Val Asp Tyr Val Asn Tyr Asn Phe Ser Asn Ile Lys Ile Ser Ala
              75                  80                  85

 ttt tca ttt cca aat acc tca ttg gct ttt gtg cct gga gtg gga atc      402
 Phe Ser Phe Pro Asn Thr Ser Leu Ala Phe Val Pro Gly Val Gly Ile
          90                  95                 100

 aaa gcg cta acc aac cat ggc act gcc aac atc agc aca gac tgg ggg      450
 Lys Ala Leu Thr Asn His Gly Thr Ala Asn Ile Ser Thr Asp Trp Gly
     105                 110                 115

 ttc gag tct cca ctt ttc caa gac aca gga ggg gct gat ctg ttt ctc      498
 Phe Glu Ser Pro Leu Phe Gln Asp Thr Gly Gly Ala Asp Leu Phe Leu
 120                 125                 130                 135

 tcc gga gtc tac ttt acc ggt atc att atc cta acc cga aat gac ttt      546
 Ser Gly Val Tyr Phe Thr Gly Ile Ile Ile Leu Thr Arg Asn Asp Phe
                 140                 145                 150

 ggt cat cct acc ctg aag ctc caa gat tgc tac gcc caa ctg agc cat      594
 Gly His Pro Thr Leu Lys Leu Gln Asp Cys Tyr Ala Gln Leu Ser His
             155                 160                 165

 gcc cac gtc tca ttt tcc gga gaa ctc agt gtt ctg tat aac tcc ttt      642
 Ala His Val Ser Phe Ser Gly Glu Leu Ser Val Leu Tyr Asn Ser Phe
         170                 175                 180

 gct gag ccc atg gag aaa ccc att tta aag aac tta aat gaa atg ctc      690
 Ala Glu Pro Met Glu Lys Pro Ile Leu Lys Asn Leu Asn Glu Met Leu
     185                 190                 195

 tgt ccc att att gca agt gaa gtc aaa gcg cta aat gcc aac ctc agc      738
 Cys Pro Ile Ile Ala Ser Glu Val Lys Ala Leu Asn Ala Asn Leu Ser
 200                 205                 210                 215

 aca ctg gag gtt tta acc aag att gac aac tac act ctg ctg gat tac      786
 Thr Leu Glu Val Leu Thr Lys Ile Asp Asn Tyr Thr Leu Leu Asp Tyr
                 220                 225                 230

 tcc cta atc agt tct cca gaa att act gag aac tac ctt gac ctg aac      834
 Ser Leu Ile Ser Ser Pro Glu Ile Thr Glu Asn Tyr Leu Asp Leu Asn
             235                 240                 245

 ttg aag ggt gta ttc tac cca ctg gaa aac ctc acc gac ccc ccc ttc      882
 Leu Lys Gly Val Phe Tyr Pro Leu Glu Asn Leu Thr Asp Pro Pro Phe
         250                 255                 260

 tca cca gtt cct ttt gtg ctc cca gaa cgc agc aac tcc atg ctc tac      930
 Ser Pro Val Pro Phe Val Leu Pro Glu Arg Ser Asn Ser Met Leu Tyr
     265                 270                 275

 att gga atc gcc gag tat ttc ttt aaa tct gcg tcc ttt gct cat ttc      978
 Ile Gly Ile Ala Glu Tyr Phe Phe Lys Ser Ala Ser Phe Ala His Phe
 280                 285                 290                 295

 aca gct ggg gtt ttc aat gtc act ctc tcc acc gaa gag att tcc aac     1026
 Thr Ala Gly Val Phe Asn Val Thr Leu Ser Thr Glu Glu Ile Ser Asn
                 300                 305                 310

 cat ttt gtt caa aac tct caa ggc ctt ggc aac gtg ctc tcc cgg att     1074
 His Phe Val Gln Asn Ser Gln Gly Leu Gly Asn Val Leu Ser Arg Ile
             315                 320                 325

 gca gag atc tac atc ttg tcc cag ccc ttc atg gtg agg atc atg gcc     1122
 Ala Glu Ile Tyr Ile Leu Ser Gln Pro Phe Met Val Arg Ile Met Ala
         330                 335                 340

 aca gag cct ccc ata atc aat cta caa cca ggc aat ttc acc ctg gac     1170
 Thr Glu Pro Pro Ile Ile Asn Leu Gln Pro Gly Asn Phe Thr Leu Asp
     345                 350                 355

 atc cct gcc tcc atc atg atg ctc acc caa ccc aag aac tcc aca gtt     1218
 Ile Pro Ala Ser Ile Met Met Leu Thr Gln Pro Lys Asn Ser Thr Val
 360                 365                 370                 375

 gaa acc atc gtt tcc atg gac ttc gtt gct agt acc agt gtt ggc ctg     1266
 Glu Thr Ile Val Ser Met Asp Phe Val Ala Ser Thr Ser Val Gly Leu
                 380                 385                 390

 gtt att ttg gga caa aga ctg gtc tgc tcc ttg tct ctg aac aga ttc     1314
 Val Ile Leu Gly Gln Arg Leu Val Cys Ser Leu Ser Leu Asn Arg Phe
             395                 400                 405

 cgc ctt gct ttg cca gag tcc aat cgc agc aac att gag gtc ttg agg     1362
 Arg Leu Ala Leu Pro Glu Ser Asn Arg Ser Asn Ile Glu Val Leu Arg
         410                 415                 420

 ttt gaa aat att cta tcg tcc att ctt cac ttt gga gtc ctc cca ctg     1410
 Phe Glu Asn Ile Leu Ser Ser Ile Leu His Phe Gly Val Leu Pro Leu
     425                 430                 435

 gcc aat gca aaa ttg cag caa gga ttt cct ctg ccc aat cca cac aaa     1458
 Ala Asn Ala Lys Leu Gln Gln Gly Phe Pro Leu Pro Asn Pro His Lys
 440                 445                 450                 455

 ttc tta ttc gtc aat tca gat att gaa gtt ctt gag ggt ttc ctt ttg     1506
 Phe Leu Phe Val Asn Ser Asp Ile Glu Val Leu Glu Gly Phe Leu Leu
                 460                 465                 470

 att tcc acc gac ctg aag tat gaa aca tcc tca aag cag cag cca agt     1554
 Ile Ser Thr Asp Leu Lys Tyr Glu Thr Ser Ser Lys Gln Gln Pro Ser
             475                 480                 485

 ttc cac gta tgg gaa ggt ctg aac ctg ata agc aga cag tgg agg ggg     1602
 Phe His Val Trp Glu Gly Leu Asn Leu Ile Ser Arg Gln Trp Arg Gly
         490                 495                 500

 aag tca gcc cct tga ttgccggttt gcaattcacc ccaggaagta aatggtcctt     1657
 Lys Ser Ala Pro 
     505

 aatcctacaa ctactgtaaa cccagaaggg aaagacagta cacactggaa ttgtaaagcc   1717

 cttgtgaatt gcttaggcag aaagttttct ttcttaagcc ttcaggaacc cagaataagg   1777

 cagactctgt taaagggata aatagaggtg tctgaatgtg agtgtatgca tgctgcgtgt   1837

 gtctgtgttt atgtttgttt gtttgtttgg ggcaagaaag attctaggac aagagctagg   1897

 catgtacttc tgaccaggtg ggtaagcaac ntctaagtct gtatttgtat tggtcattct   1957

 cagtggaaat cccttaggcc ctctagtggt tttcccctac ctgcatattg gttttcatgt   2017

 tttatattca ctgttactat cttctgtgtt taattaaaat tgttttctat caa          2070




      <210> 550
      <211> 3017
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(1842)

      <400> 550
 gcc  atg gcg gac ttc gct ggg ccg tct tct gcc ggc cgc aag gcc ggg      48
      Met Ala Asp Phe Ala Gly Pro Ser Ser Ala Gly Arg Lys Ala Gly
        1               5                  10                  15

 gct ccc cgc tgc tct cga aaa gcc gca ggt act aaa cag aca agt act       96
 Ala Pro Arg Cys Ser Arg Lys Ala Ala Gly Thr Lys Gln Thr Ser Thr
                  20                  25                  30

 ttg aaa caa gaa gat gct tct aaa agg aaa gct gaa cta gaa gca gct      144
 Leu Lys Gln Glu Asp Ala Ser Lys Arg Lys Ala Glu Leu Glu Ala Ala
              35                  40                  45

 gtg aga aag aag att gaa ttt gag aga aaa gct cta cat att gtt gaa      192
 Val Arg Lys Lys Ile Glu Phe Glu Arg Lys Ala Leu His Ile Val Glu
          50                  55                  60

 cag ctt tta gag gag aat att aca gaa gag ttc cta atg gag tgt ggg      240
 Gln Leu Leu Glu Glu Asn Ile Thr Glu Glu Phe Leu Met Glu Cys Gly
      65                  70                  75

 agg ttc att aca cct gct cac tac agt gat gtc gtg gat gaa cgt tct      288
 Arg Phe Ile Thr Pro Ala His Tyr Ser Asp Val Val Asp Glu Arg Ser
  80                  85                  90                  95

 att gtc aaa ctc tgt ggt tat cct tta tgt cag aag aag ctg gga att      336
 Ile Val Lys Leu Cys Gly Tyr Pro Leu Cys Gln Lys Lys Leu Gly Ile
                 100                 105                 110

 gta cca aaa cag aaa tat aaa att tct acc aaa acc aat aaa gtc tat      384
 Val Pro Lys Gln Lys Tyr Lys Ile Ser Thr Lys Thr Asn Lys Val Tyr
             115                 120                 125

 gat att act gaa aga aag tct ttt tgc agc aat ttt tgt tat caa gca      432
 Asp Ile Thr Glu Arg Lys Ser Phe Cys Ser Asn Phe Cys Tyr Gln Ala
         130                 135                 140

 tct aag ttt ttt gaa gca caa att ccc aaa act cca gta tgg gtt cga      480
 Ser Lys Phe Phe Glu Ala Gln Ile Pro Lys Thr Pro Val Trp Val Arg
     145                 150                 155

 gaa gaa gag agg cat cct gat ttt caa ctg cta aag gaa gaa caa agt      528
 Glu Glu Glu Arg His Pro Asp Phe Gln Leu Leu Lys Glu Glu Gln Ser
 160                 165                 170                 175

 ggc cat tct gga gaa gaa gta cag tta tgc agt aaa gcc att aaa aca      576
 Gly His Ser Gly Glu Glu Val Gln Leu Cys Ser Lys Ala Ile Lys Thr
                 180                 185                 190

 tca gat atc gac aat cct agc cac ttt gaa aag caa tat gaa tct agt      624
 Ser Asp Ile Asp Asn Pro Ser His Phe Glu Lys Gln Tyr Glu Ser Ser
             195                 200                 205

 tct tct agc act cac agt gat agt agc agt gac aat gag caa gac ttt      672
 Ser Ser Ser Thr His Ser Asp Ser Ser Ser Asp Asn Glu Gln Asp Phe
         210                 215                 220

 gtt tcc tcc att cta cca gga aac aga cca aat tca aca aat att aga      720
 Val Ser Ser Ile Leu Pro Gly Asn Arg Pro Asn Ser Thr Asn Ile Arg
     225                 230                 235

 cca cag ctg cac caa aaa agc ata atg aaa aag aaa gct ggt cac aaa      768
 Pro Gln Leu His Gln Lys Ser Ile Met Lys Lys Lys Ala Gly His Lys
 240                 245                 250                 255

 gct aac tcc aaa cac aaa gac aaa gaa cag aca gta gta gat gtc act      816
 Ala Asn Ser Lys His Lys Asp Lys Glu Gln Thr Val Val Asp Val Thr
                 260                 265                 270

 gag cag tta ggc gat tgc aaa tta gat agt cag gag aaa gat gct aca      864
 Glu Gln Leu Gly Asp Cys Lys Leu Asp Ser Gln Glu Lys Asp Ala Thr
             275                 280                 285

 tgt gaa ctt cct tta cag aaa gta aat act cag agt tct tca aat agc      912
 Cys Glu Leu Pro Leu Gln Lys Val Asn Thr Gln Ser Ser Ser Asn Ser
         290                 295                 300

 act ttg cct gaa aga tta aaa gcg tca gaa aat tct gaa agt gaa tac      960
 Thr Leu Pro Glu Arg Leu Lys Ala Ser Glu Asn Ser Glu Ser Glu Tyr
     305                 310                 315

 agt agg tca gaa ata act cta gta ggc ata agt aag aaa agt gca gag     1008
 Ser Arg Ser Glu Ile Thr Leu Val Gly Ile Ser Lys Lys Ser Ala Glu
 320                 325                 330                 335

 cat ttt aag aga aaa ttt gcc aaa tca aac caa gtg tct agg tca gtg     1056
 His Phe Lys Arg Lys Phe Ala Lys Ser Asn Gln Val Ser Arg Ser Val
                 340                 345                 350

 tct agt tca gtg cag gtg tgt cct gaa gtt gga aag aga aac tta ctt     1104
 Ser Ser Ser Val Gln Val Cys Pro Glu Val Gly Lys Arg Asn Leu Leu
             355                 360                 365

 aaa gtt ttg aag gag act ttg att gag tgg aag aca gaa gaa aca ttg     1152
 Lys Val Leu Lys Glu Thr Leu Ile Glu Trp Lys Thr Glu Glu Thr Leu
         370                 375                 380

 agg ttt ttg tat ggc cag aat tat gct tct gtg tgt ctg aaa ccc gaa     1200
 Arg Phe Leu Tyr Gly Gln Asn Tyr Ala Ser Val Cys Leu Lys Pro Glu
     385                 390                 395

 gcc tct ctg gtt aaa gaa gaa ctt gat gaa gat gac ata atc tca gat     1248
 Ala Ser Leu Val Lys Glu Glu Leu Asp Glu Asp Asp Ile Ile Ser Asp
 400                 405                 410                 415

 cca gat agt cat ttc cct gcc tgg agg gaa tct cag aac agc ttg gat     1296
 Pro Asp Ser His Phe Pro Ala Trp Arg Glu Ser Gln Asn Ser Leu Asp
                 420                 425                 430

 gag tct tta cct ttt agg ggc tca ggt aca gcc att aaa cca ctg cca     1344
 Glu Ser Leu Pro Phe Arg Gly Ser Gly Thr Ala Ile Lys Pro Leu Pro
             435                 440                 445

 agt tac gag aat ttg aaa aaa gaa act gaa aag tta aat ctg agg atc     1392
 Ser Tyr Glu Asn Leu Lys Lys Glu Thr Glu Lys Leu Asn Leu Arg Ile
         450                 455                 460

 agg gag ttt tac aga gga cgg tat gtt ttg ggt gaa gaa acc acc aaa     1440
 Arg Glu Phe Tyr Arg Gly Arg Tyr Val Leu Gly Glu Glu Thr Thr Lys
     465                 470                 475

 tca caa gac tca gaa gag cat gat tcc acc ttt cca ctg ata gac tca     1488
 Ser Gln Asp Ser Glu Glu His Asp Ser Thr Phe Pro Leu Ile Asp Ser
 480                 485                 490                 495

 agt tcc cag aac cag att aga aaa cgc atc gta ctt gaa aag ttg agt     1536
 Ser Ser Gln Asn Gln Ile Arg Lys Arg Ile Val Leu Glu Lys Leu Ser
                 500                 505                 510

 aaa gtg ttg cct ggg ctt ctg gtt cct ctt cag att aca ttg gga gat     1584
 Lys Val Leu Pro Gly Leu Leu Val Pro Leu Gln Ile Thr Leu Gly Asp
             515                 520                 525

 att tac aca caa ctt aaa aat ctt gtt cga act ttc agg tta aca aat     1632
 Ile Tyr Thr Gln Leu Lys Asn Leu Val Arg Thr Phe Arg Leu Thr Asn
         530                 535                 540

 aga aat att ata cac aaa cct gcg gaa tgg act tta att gct atg gtg     1680
 Arg Asn Ile Ile His Lys Pro Ala Glu Trp Thr Leu Ile Ala Met Val
     545                 550                 555

 ttg ctg tca tta ctg acc cca att ctt ggc att cag aaa cat tct cag     1728
 Leu Leu Ser Leu Leu Thr Pro Ile Leu Gly Ile Gln Lys His Ser Gln
 560                 565                 570                 575

 gaa ggt atg gtg ttt aca cgg ttt cta gac acc ctc ctt gaa gaa tta     1776
 Glu Gly Met Val Phe Thr Arg Phe Leu Asp Thr Leu Leu Glu Glu Leu
                 580                 585                 590

 cat cta aaa aat gaa gac ctt gaa agt cta acc atc ata ttt aga acc     1824
 His Leu Lys Asn Glu Asp Leu Glu Ser Leu Thr Ile Ile Phe Arg Thr
             595                 600                 605

 agc tgt tta cca gag tga tatatt ccatgaagac aaaatagaag atgaacttct     1878
 Ser Cys Leu Pro Glu 
         610

 attcaccgtt tctggaattc tagccgccat gatggtctgg tggtgactga taactagttt   1938

 tattccaaga cataccttta cctctttaag tttcaatctc ccatctccca gtccttcagt   1998

 ccccaactgc agaggatgac ctccccagat agaggagaat cattactcca acaagaataa   2058

 ccaagtcttt gtatccctag tacaagacat agtattttta ttcgaaaatg aatgtttaag   2118

 tattaaattg aaacttgaat gaatattcaa gaaaatataa tgatctctac tttttctgga   2178

 tgattccagc catcatatca gtttgccaaa aaaattgaga aagttatgat tttgacctcc   2238

 caacctaaac tctaaattct aaagatcagt aaacaattag gtcaataaat acatacaatt   2298

 taagatgaag ccctttggaa gtctagtcca aaacaggaaa atctcagaac tttctggact   2358

 caaggaaatg ctttaaatgg aatctgtagt ttgtttgcag gagagacaat ttctagaatt   2418

 tagattgctt ttcaaaatgt ttatcaggta ggcaagttag cagttgaggc ggaacacaga   2478

 caacttgggg agctttactg gaaggccaag aaaatactct tggacactgg aggaaatgac   2538

 agctactaaa gcccaatcat ggaaaaggac cagaaagcag cccactggaa tggggagctt   2598

 agtgggcaag gaggtaggga tataatttct cttcttggct ccaccagtaa ttagctctgt   2658

 ggcccagtca cctaaacttt ctggacttca gttcaggttg tatggcagta ggccatagaa   2718

 ttggctactg ccatacaatc tctatgggaa aggactgcaa aaactaaatt ttatctctgt   2778

 atgggcaaag gctactgtca tcctgttgtt ggtctggggc cactctgaca atttttttta   2838

 acctcatttg attgtgtaag ggtctaacca caacaaaaaa tcatagtgta atagaattaa   2898

 tcaagttcag caaggtcaca ggctagatca atatacagaa aatcaattgt atttttctgt   2958

 tcagaaaact ccaaaaatga aataaagaaa attgtgttca caataaaaaa aaaaaaaaa    3017




      <210> 551
      <211> 384
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(384)

      <400> 551
  atg cca act atg tgg agg atg cta cac caa gca ctg aag ctc aga agg      48
  Met Pro Thr Met Trp Arg Met Leu His Gln Ala Leu Lys Leu Arg Arg
    1               5                  10                  15

 aga aca gtt ttg gca ggg caa gaa ata agc tat gtt cta cct gtt atg       96
 Arg Thr Val Leu Ala Gly Gln Glu Ile Ser Tyr Val Leu Pro Val Met
              20                  25                  30

 ttt gtg gta agt gag gaa gat tca aac aga gat gtc ttt ttg gta gct      144
 Phe Val Val Ser Glu Glu Asp Ser Asn Arg Asp Val Phe Leu Val Ala
          35                  40                  45

 gga tat agg cat ttg gag ttt gga gag agg ata gca att tgg gga tcc      192
 Gly Tyr Arg His Leu Glu Phe Gly Glu Arg Ile Ala Ile Trp Gly Ser
      50                  55                  60

 tca atg cag cat gta gag agg agg aga tgg ccc ctg gac agc ata cag      240
 Ser Met Gln His Val Glu Arg Arg Arg Trp Pro Leu Asp Ser Ile Gln
  65                  70                  75                  80

 aaa aga atg ggc caa agt ttc acg ggg tgg gca gaa gaa gct gcc ccg      288
 Lys Arg Met Gly Gln Ser Phe Thr Gly Trp Ala Glu Glu Ala Ala Pro
                  85                  90                  95

 gga atg aag acg aag aag gaa tat gca gag att ggg gta aaa cca aga      336
 Gly Met Lys Thr Lys Lys Glu Tyr Ala Glu Ile Gly Val Lys Pro Arg
             100                 105                 110

 cag aat gct tgt gaa atg tgc cca gga atg atc ctc tcc act act taa      384
 Gln Asn Ala Cys Glu Met Cys Pro Gly Met Ile Leu Ser Thr Thr 
         115                 120                 125





      <210> 552
      <211> 978
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(750)

      <400> 552
 ggcgggtgct gggagccagc gcctgcctcg ccgccgccct cgctgcctgc cactccgtct     60

 tggcccgttc tccgcaccgt gcagaggcgg cgggctgggg agggagcggc gccagcacga    120

 ggttcccagc cgctgggaag cccctagacg cgccgagggg ccgggctacg agcggctgag    180

 aaa  atg atg cat cct gtt gcc agc agt aat cca gct ttc tgt ggg cct     228
      Met Met His Pro Val Ala Ser Ser Asn Pro Ala Phe Cys Gly Pro
        1               5                  10                  15

 ggc aag cct tcc tgc ctc aat gaa gat gcc atg aga gct gct gat cag      276
 Gly Lys Pro Ser Cys Leu Asn Glu Asp Ala Met Arg Ala Ala Asp Gln
                  20                  25                  30

 ttt gac ata tat tcc tcc cag caa agc aaa tac agc cac aca gtc aac      324
 Phe Asp Ile Tyr Ser Ser Gln Gln Ser Lys Tyr Ser His Thr Val Asn
              35                  40                  45

 cac aaa cca atg gtt tgt cag agg caa gac cca tta aat gaa aca cac      372
 His Lys Pro Met Val Cys Gln Arg Gln Asp Pro Leu Asn Glu Thr His
          50                  55                  60

 ttg cag act aca agt ggc aga agc ata gaa ata aaa gat gaa cta aag      420
 Leu Gln Thr Thr Ser Gly Arg Ser Ile Glu Ile Lys Asp Glu Leu Lys
      65                  70                  75

 aaa aag aag aat ctc aac cga tct ggt aag cgt ggc cgg cct tcg gga      468
 Lys Lys Lys Asn Leu Asn Arg Ser Gly Lys Arg Gly Arg Pro Ser Gly
  80                  85                  90                  95

 acc acc aaa tca gca gga tac cgg acc agc aca ggc aga ccc ctg gga      516
 Thr Thr Lys Ser Ala Gly Tyr Arg Thr Ser Thr Gly Arg Pro Leu Gly
                 100                 105                 110

 acc acc aaa gca gct gga ttt aag aca agt cca ggc aga cct ttg ggg      564
 Thr Thr Lys Ala Ala Gly Phe Lys Thr Ser Pro Gly Arg Pro Leu Gly
             115                 120                 125

 aca act aaa gct gcg gga tac aaa gtc agc cca ggc aga cct cca ggt      612
 Thr Thr Lys Ala Ala Gly Tyr Lys Val Ser Pro Gly Arg Pro Pro Gly
         130                 135                 140

 agc att aaa gct cta tcc cgt ctt gcc gat ctt ggt tat ggc tgt ggc      660
 Ser Ile Lys Ala Leu Ser Arg Leu Ala Asp Leu Gly Tyr Gly Cys Gly
     145                 150                 155

 act gct gct ttt cct tac cct atg atg cat ggc aga gca gtt cat ggg      708
 Thr Ala Ala Phe Pro Tyr Pro Met Met His Gly Arg Ala Val His Gly
 160                 165                 170                 175

 gta gag gaa act agc agt gaa gtc aaa cca ccc aat gag tga atgaggc      757
 Val Glu Glu Thr Ser Ser Glu Val Lys Pro Pro Asn Glu 
                 180                 185

 aggaaaagag ggccaggttt agaaggaaga ttgtgaataa tcccaaagct tcttgggttt    817

 tattttgata tacataattt tatggcctgg gctttccaaa tttgttttcc tgtttgggtt    877

 ttttcctgct tttgctcaaa aactgccata tgctgacaga tgcactcagg gcatgagcag    937

 cggcattgta tttgtacata ggttcaagtg taacacctaa c                        978




      <210> 553
      <211> 2108
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (42)..(2108)

      <400> 553
 ggccccaagg tactgtttat aagggctgta cctacgtggg g    atg tgt gtg att      53
                                                  Met Cys Val Ile
                                                    1

 gat tac ctg cac aga acc aga gcc atg tcg gac ttc cac gtg cat ccc      101
 Asp Tyr Leu His Arg Thr Arg Ala Met Ser Asp Phe His Val His Pro
   5                  10                  15                  20

 cag gcc acc gtg ggt gag gag ggt ggt gtg gcc cgc ttc cag tgc caa      149
 Gln Ala Thr Val Gly Glu Glu Gly Gly Val Ala Arg Phe Gln Cys Gln
                  25                  30                  35

 atc cat ggg ctt ccc aaa ccc ctg atc act tgg gag aag aac aga gtc      197
 Ile His Gly Leu Pro Lys Pro Leu Ile Thr Trp Glu Lys Asn Arg Val
              40                  45                  50

 cca att gac acg gac aat gag agg tac aca ttg ctg ccc aag ggg gtc      245
 Pro Ile Asp Thr Asp Asn Glu Arg Tyr Thr Leu Leu Pro Lys Gly Val
          55                  60                  65

 ctg cag atc aca gga ctt cga gct gag gac ggt ggc atc ttc cac tgt      293
 Leu Gln Ile Thr Gly Leu Arg Ala Glu Asp Gly Gly Ile Phe His Cys
      70                  75                  80

 gtg gcc tca aac atc gcc agt atc cgg atc agc cac ggg gcc agg ctc      341
 Val Ala Ser Asn Ile Ala Ser Ile Arg Ile Ser His Gly Ala Arg Leu
  85                  90                  95                 100

 act gtg tca ggc tcg ggc tct ggg gcc tac aag gag cca gcc atc ctc      389
 Thr Val Ser Gly Ser Gly Ser Gly Ala Tyr Lys Glu Pro Ala Ile Leu
                 105                 110                 115

 gtg ggg cct gag aac ctc acc ctg aca gtg cac cag acc gcg gtg ctt      437
 Val Gly Pro Glu Asn Leu Thr Leu Thr Val His Gln Thr Ala Val Leu
             120                 125                 130

 gag tgt gtc gcc acg ggc aac ccg cgc ccc att gtg tcc tgg agc cgc      485
 Glu Cys Val Ala Thr Gly Asn Pro Arg Pro Ile Val Ser Trp Ser Arg
         135                 140                 145

 ctg gat ggt cgc cct atc ggg gtg gag ggc atc cag gtg ctg ggc aca      533
 Leu Asp Gly Arg Pro Ile Gly Val Glu Gly Ile Gln Val Leu Gly Thr
     150                 155                 160

 gga aac ctc atc atc tca gac gtg acg gtc cag cac tct ggc gtc tac      581
 Gly Asn Leu Ile Ile Ser Asp Val Thr Val Gln His Ser Gly Val Tyr
 165                 170                 175                 180

 gtc tgt gca gcc aac aga cct ggc acc cgg gtg agg aga acg gca cag      629
 Val Cys Ala Ala Asn Arg Pro Gly Thr Arg Val Arg Arg Thr Ala Gln
                 185                 190                 195

 ggc cgg ctg gtg gtg caa gcc cca gct gag ttt gtg cag cat ccc cag      677
 Gly Arg Leu Val Val Gln Ala Pro Ala Glu Phe Val Gln His Pro Gln
             200                 205                 210

 tcc atc tcc agg cca gct ggg acc aca gcc atg ttc acc tgc caa gcc      725
 Ser Ile Ser Arg Pro Ala Gly Thr Thr Ala Met Phe Thr Cys Gln Ala
         215                 220                 225

 cag ggt gag cca ccg cct cat gtc acg tgg ctg aaa aat gga cag gtg      773
 Gln Gly Glu Pro Pro Pro His Val Thr Trp Leu Lys Asn Gly Gln Val
     230                 235                 240

 ctg ggg cca gga ggc cac gtc agg ctc aag aat aac aac agc aca ctg      821
 Leu Gly Pro Gly Gly His Val Arg Leu Lys Asn Asn Asn Ser Thr Leu
 245                 250                 255                 260

 acc att tct gga atc ggt cct gag gat gaa gcc att tat cag tgt gtg      869
 Thr Ile Ser Gly Ile Gly Pro Glu Asp Glu Ala Ile Tyr Gln Cys Val
                 265                 270                 275

 gcc gag aac agt gcg ggc tca tca cag gcc agt gcc agg ctg acc gta      917
 Ala Glu Asn Ser Ala Gly Ser Ser Gln Ala Ser Ala Arg Leu Thr Val
             280                 285                 290

 ctg tgg gct gag ggg ctc ccc ggg cct ccc cgc aat gtg cgg gca gtc      965
 Leu Trp Ala Glu Gly Leu Pro Gly Pro Pro Arg Asn Val Arg Ala Val
         295                 300                 305

 tct gtg tct tcc act gag gtg cgt gtg tcc tgg agt gag ccg ctg gcc     1013
 Ser Val Ser Ser Thr Glu Val Arg Val Ser Trp Ser Glu Pro Leu Ala
     310                 315                 320

 aac acc aag gag atc atc ggc tac gtc ctg cac atc agg aag gct gct     1061
 Asn Thr Lys Glu Ile Ile Gly Tyr Val Leu His Ile Arg Lys Ala Ala
 325                 330                 335                 340

 gac cca ccg gag ctg gag tat cag gag gca gtc agc aag agc acc ttt     1109
 Asp Pro Pro Glu Leu Glu Tyr Gln Glu Ala Val Ser Lys Ser Thr Phe
                 345                 350                 355

 cag cac ctg gtc agc gac ctg gag ccc tcc aca gcc tac agt ttc tac     1157
 Gln His Leu Val Ser Asp Leu Glu Pro Ser Thr Ala Tyr Ser Phe Tyr
             360                 365                 370

 atc aag gcc tac aca cca agg ggg gcc agc tca gcc tct gtg ccc acc     1205
 Ile Lys Ala Tyr Thr Pro Arg Gly Ala Ser Ser Ala Ser Val Pro Thr
         375                 380                 385

 cta gct agc acc ctg ggt gaa gcc cct gcc cca ccc cca ctg tca gtg     1253
 Leu Ala Ser Thr Leu Gly Glu Ala Pro Ala Pro Pro Pro Leu Ser Val
     390                 395                 400

 cga gtc ctg ggc agc tcc tcc ttg cag ctg ctg tgg gag cct tgg ccc     1301
 Arg Val Leu Gly Ser Ser Ser Leu Gln Leu Leu Trp Glu Pro Trp Pro
 405                 410                 415                 420

 cgg ctg gcc cag cac gag ggc ggc ttc aag ctg ttt tac cgc cca gca     1349
 Arg Leu Ala Gln His Glu Gly Gly Phe Lys Leu Phe Tyr Arg Pro Ala
                 425                 430                 435

 agc aag acc tcc ttc acc ggc ccc atc ctg ctg cct gga acc gtc tcc     1397
 Ser Lys Thr Ser Phe Thr Gly Pro Ile Leu Leu Pro Gly Thr Val Ser
             440                 445                 450

 tcc tac aac ctc agc cag ctc gac ccc act gca gtg tat gag gtg aag     1445
 Ser Tyr Asn Leu Ser Gln Leu Asp Pro Thr Ala Val Tyr Glu Val Lys
         455                 460                 465

 ctg ctc gcc tac aac cag cat gga gat ggc aat gcc aca gtc cgc ttt     1493
 Leu Leu Ala Tyr Asn Gln His Gly Asp Gly Asn Ala Thr Val Arg Phe
     470                 475                 480

 gtg tct ttg agg gga gca tct gag agg aca gcc ttg agc cca cca tgt     1541
 Val Ser Leu Arg Gly Ala Ser Glu Arg Thr Ala Leu Ser Pro Pro Cys
 485                 490                 495                 500

 gac tgc cgg aag gag gag gcc gcc aac cag acg tcc acc aca ggc atc     1589
 Asp Cys Arg Lys Glu Glu Ala Ala Asn Gln Thr Ser Thr Thr Gly Ile
                 505                 510                 515

 gtc atc ggc atc cac atc ggg gtc act tgc atc atc ttc tgt gtc ctc     1637
 Val Ile Gly Ile His Ile Gly Val Thr Cys Ile Ile Phe Cys Val Leu
             520                 525                 530

 ttc ctc ctg ttc ggc caa agg ggc agg gtc ctc ctg tgt aaa gat gtg     1685
 Phe Leu Leu Phe Gly Gln Arg Gly Arg Val Leu Leu Cys Lys Asp Val
         535                 540                 545

 gaa aac cag ctg tcc cct cca cag ggt ccc cgg agc cag agg gac cct     1733
 Glu Asn Gln Leu Ser Pro Pro Gln Gly Pro Arg Ser Gln Arg Asp Pro
     550                 555                 560

 ggc att ctg gcc cta aat ggg gcg aga cgg gga cag cgg ggc cag ctg     1781
 Gly Ile Leu Ala Leu Asn Gly Ala Arg Arg Gly Gln Arg Gly Gln Leu
 565                 570                 575                 580

 ggc cga gac gag aaa cgt gtg gat atg aag gag ctg gag cag ctg ttc     1829
 Gly Arg Asp Glu Lys Arg Val Asp Met Lys Glu Leu Glu Gln Leu Phe
                 585                 590                 595

 ccc ccg gcc agc gca gca ggg cag ccg gac ccc aga ccc aca gat cct     1877
 Pro Pro Ala Ser Ala Ala Gly Gln Pro Asp Pro Arg Pro Thr Asp Pro
             600                 605                 610

 gca gcc ccc gct ccg tgt gag gag acc cag ctc tcc gtg ctg cca ctt     1925
 Ala Ala Pro Ala Pro Cys Glu Glu Thr Gln Leu Ser Val Leu Pro Leu
         615                 620                 625

 cag ggg tgc ggc ctg atg gag ggg aag acg acg gag gcg aag acc aca     1973
 Gln Gly Cys Gly Leu Met Glu Gly Lys Thr Thr Glu Ala Lys Thr Thr
     630                 635                 640

 gag gcc acg gct ccc tgc gcc ggc ctg gcg gct gcc cca cca ccc cca     2021
 Glu Ala Thr Ala Pro Cys Ala Gly Leu Ala Ala Ala Pro Pro Pro Pro
 645                 650                 655                 660

 gat gga ggc cct ggc ctc ctc agt gaa ggc cag gct tcc agg cct gca     2069
 Asp Gly Gly Pro Gly Leu Leu Ser Glu Gly Gln Ala Ser Arg Pro Ala
                 665                 670                 675

 gcg gcc cgg gtt acc cag cca gct cac tcg gaa cag tag                 2108
 Ala Ala Arg Val Thr Gln Pro Ala His Ser Glu Gln 
             680                 685





      <210> 554
      <211> 2237
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (263)..(1657)

      <220>
      <221> misc_feature
      <222> (1)...(2237)
      <223> n = a,t,c or g

      <400> 554
 ttgaaaagtg atgacggttg acgtttgctg atttttgact ttgcttgtag ctgctccccg     60

 aactcgccgt cttcctgtcg gcggccggca ctgtaggtga gcgcgagagg acggaggaag    120

 gaagcctgca gacagacgcc ttctccatcc caaggcgcgg gcaggtgccg ggacgctggg    180

 cctggcggtg ttttcgtcgt gctcagcggt gggaggaggc ggaagaaacc agagcctggg    240

 agattaacag gaaacttcca ag atg gaa act ttg tct ttc ccc aga tat aat     292
                          Met Glu Thr Leu Ser Phe Pro Arg Tyr Asn
                            1               5                  10

 gta gct gag att gtg att cat att cgc aat aag atc tta aca gga gct      340
 Val Ala Glu Ile Val Ile His Ile Arg Asn Lys Ile Leu Thr Gly Ala
                  15                  20                  25

 gat ggt aaa aac ctc acc aag aat gat ctt tat cca aat cca aag cct      388
 Asp Gly Lys Asn Leu Thr Lys Asn Asp Leu Tyr Pro Asn Pro Lys Pro
              30                  35                  40

 gaa gtc ttg cac atg atc tac atg aga gcc tta caa ata gtc tat gga      436
 Glu Val Leu His Met Ile Tyr Met Arg Ala Leu Gln Ile Val Tyr Gly
          45                  50                  55

 att cga ctg gaa cat ttt tac atg atg cca gtg aac tct gaa gtc atg      484
 Ile Arg Leu Glu His Phe Tyr Met Met Pro Val Asn Ser Glu Val Met
      60                  65                  70

 tat cca cat tta atg gaa ggc ttc tta cca ttc agc aat tta gtt act      532
 Tyr Pro His Leu Met Glu Gly Phe Leu Pro Phe Ser Asn Leu Val Thr
  75                  80                  85                  90

 cat ctg gac tca ttt ttg cct atc tgc cgg gtg aat gac ttt gag act      580
 His Leu Asp Ser Phe Leu Pro Ile Cys Arg Val Asn Asp Phe Glu Thr
                  95                 100                 105

 gct gat att cta tgt cca aaa gca aaa cgg aca agt cgg ttt tta agt      628
 Ala Asp Ile Leu Cys Pro Lys Ala Lys Arg Thr Ser Arg Phe Leu Ser
             110                 115                 120

 ggc att atc aac ttt att cac ttc aga gaa gca tgc cgt gaa acg tat      676
 Gly Ile Ile Asn Phe Ile His Phe Arg Glu Ala Cys Arg Glu Thr Tyr
         125                 130                 135

 atg gaa ttt ctt tgg caa tat aaa tcc tct gcg gac aaa atg caa cag      724
 Met Glu Phe Leu Trp Gln Tyr Lys Ser Ser Ala Asp Lys Met Gln Gln
     140                 145                 150

 tta aac gcc gca cac cag gag gca tta atg aaa ctg gag aga ctt gat      772
 Leu Asn Ala Ala His Gln Glu Ala Leu Met Lys Leu Glu Arg Leu Asp
 155                 160                 165                 170

 tct gtt cca gtt gaa gag caa gaa gag ttc aag cag ctt tca gat gga      820
 Ser Val Pro Val Glu Glu Gln Glu Glu Phe Lys Gln Leu Ser Asp Gly
                 175                 180                 185

 att cag gag cta caa caa tca cta aat cag gat ttt cat caa aaa acg      868
 Ile Gln Glu Leu Gln Gln Ser Leu Asn Gln Asp Phe His Gln Lys Thr
             190                 195                 200

 ata gtg ctg caa gag gga aat tcc caa aag aag tca aat att tca gag      916
 Ile Val Leu Gln Glu Gly Asn Ser Gln Lys Lys Ser Asn Ile Ser Glu
         205                 210                 215

 aaa acc aag cgt ttg aat gaa cta aaa ttg tcg gtg gtt tct ttg aaa      964
 Lys Thr Lys Arg Leu Asn Glu Leu Lys Leu Ser Val Val Ser Leu Lys
     220                 225                 230

 gaa ata caa gag agt ttg aaa aca aaa att gtg gat tct cca gag aag     1012
 Glu Ile Gln Glu Ser Leu Lys Thr Lys Ile Val Asp Ser Pro Glu Lys
 235                 240                 245                 250

 tta aag aat tat aaa gaa aaa atg aaa gat acg gtc cag aag ctt aaa     1060
 Leu Lys Asn Tyr Lys Glu Lys Met Lys Asp Thr Val Gln Lys Leu Lys
                 255                 260                 265

 aat gcc aga caa gaa gtg gtg gag aaa tat gaa atc tat gga gac tca     1108
 Asn Ala Arg Gln Glu Val Val Glu Lys Tyr Glu Ile Tyr Gly Asp Ser
             270                 275                 280

 gtt gac tgc ctg cct tca tgt cag ttg gaa gtg cag tta tat caa aag     1156
 Val Asp Cys Leu Pro Ser Cys Gln Leu Glu Val Gln Leu Tyr Gln Lys
         285                 290                 295

 aaa ata cag gac ctt tca gat aat agg gaa aaa tta gcc agt atc tta     1204
 Lys Ile Gln Asp Leu Ser Asp Asn Arg Glu Lys Leu Ala Ser Ile Leu
     300                 305                 310

 aag gag agc ctg aac ttg gag gac caa att gag agt gat gag tca gaa     1252
 Lys Glu Ser Leu Asn Leu Glu Asp Gln Ile Glu Ser Asp Glu Ser Glu
 315                 320                 325                 330

 ctg aag aaa ttg aag act gaa gaa aat tcg ttc aaa aga ctg atg att     1300
 Leu Lys Lys Leu Lys Thr Glu Glu Asn Ser Phe Lys Arg Leu Met Ile
                 335                 340                 345

 gtg aag aag gaa aaa ctt gcc aca gca caa ttc aaa ata aat aag aag     1348
 Val Lys Lys Glu Lys Leu Ala Thr Ala Gln Phe Lys Ile Asn Lys Lys
             350                 355                 360

 cat gaa gat gtt aag caa tac aaa cgc aca gta att gag gat tgc aat     1396
 His Glu Asp Val Lys Gln Tyr Lys Arg Thr Val Ile Glu Asp Cys Asn
         365                 370                 375

 aaa gtt caa gaa aaa aga ggt gct gtc tat gaa cga gta acc aca att     1444
 Lys Val Gln Glu Lys Arg Gly Ala Val Tyr Glu Arg Val Thr Thr Ile
     380                 385                 390

 aat caa gaa atc caa aaa att aaa ctt gga att caa caa cta aaa gat     1492
 Asn Gln Glu Ile Gln Lys Ile Lys Leu Gly Ile Gln Gln Leu Lys Asp
 395                 400                 405                 410

 gct gct gaa agg gag aaa ctg aag tcc cag gaa ata ttt cta aac ttg     1540
 Ala Ala Glu Arg Glu Lys Leu Lys Ser Gln Glu Ile Phe Leu Asn Leu
                 415                 420                 425

 aaa act gct ttg gag aaa tac cac gac ggt att gaa aag gca gca gag     1588
 Lys Thr Ala Leu Glu Lys Tyr His Asp Gly Ile Glu Lys Ala Ala Glu
             430                 435                 440

 gac tcc tat gct aag ata gat gag aag aca gct gaa ctg aag agg aag     1636
 Asp Ser Tyr Ala Lys Ile Asp Glu Lys Thr Ala Glu Leu Lys Arg Lys
         445                 450                 455

 atg ttc aaa atg tca acc tga tt aacaaaatta catgtctttt tgtaaatggc     1689
 Met Phe Lys Met Ser Thr 
     460

 ttgccatctt ttaattttct atttagaaag aaaagttgaa gcgaatggaa gtatcagaag   1749

 taccaaataa tgttggcttc atcagttttt atacactctc ataagtagtt aataagatga   1809

 atttaatgta ggcttttatt aatttataat taaaataact tgtgcagcta ttcatgtctc   1869

 tactctgccc cttgttgtaa atagtttgag taaaacaaaa ctagttacct ttgaaatata   1929

 tatatttttt tctgttaggg gagaggggca tattgtaagc acagtgaggg ctaggttggt   1989

 gcaggcatgg aaacagtgtt ggangcgggc tatgttgtag ttctatctcg tgggtcgggc   2049

 gcggctaggg cttttggtga gtatgtattg taatctactg tcgttaccgt ttgctgtggt   2109

 gtagcgcctg gggagcggtc accgccgtcg gcctttgggg gtaggcgggc gggtggggca   2169

 gggtgattgg gggggagctt gccgttagtg cgggcttgtg caccgtcgat agatacgggc   2229

 gaggagag                                                            2237




      <210> 555
      <211> 2265
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2157)

      <400> 555
  atg gaa ctg ctg gac atg gtt tgc atg gac cct tta gta gat gac aat      48
  Met Glu Leu Leu Asp Met Val Cys Met Asp Pro Leu Val Asp Asp Asn
    1               5                  10                  15

 gat gat att ttg aat atg gta ata gtt att cat tct tta ttg gat atc       96
 Asp Asp Ile Leu Asn Met Val Ile Val Ile His Ser Leu Leu Asp Ile
              20                  25                  30

 tgc tct gtt att tcc agt atg gac cat gca ttt cat gcc aat act tgg      144
 Cys Ser Val Ile Ser Ser Met Asp His Ala Phe His Ala Asn Thr Trp
          35                  40                  45

 aag ttt ata att aag cag agc ctt aag cac cag tcc ata ata aaa agc      192
 Lys Phe Ile Ile Lys Gln Ser Leu Lys His Gln Ser Ile Ile Lys Ser
      50                  55                  60

 cag ttg aaa cac aaa gat ata att act agc ttg tgt gaa gac att ctt      240
 Gln Leu Lys His Lys Asp Ile Ile Thr Ser Leu Cys Glu Asp Ile Leu
  65                  70                  75                  80

 ttc tcc ttc cat tct tgt tta cag tta gct gag cag atg aca cag tca      288
 Phe Ser Phe His Ser Cys Leu Gln Leu Ala Glu Gln Met Thr Gln Ser
                  85                  90                  95

 gat gca cag gat aat gct gac tac aga tta ttt cag aaa aca ctc aaa      336
 Asp Ala Gln Asp Asn Ala Asp Tyr Arg Leu Phe Gln Lys Thr Leu Lys
             100                 105                 110

 ttg tgt cgt ttt ttt gcc aac tcc ctt ttg cac tac gct aag gaa ttt      384
 Leu Cys Arg Phe Phe Ala Asn Ser Leu Leu His Tyr Ala Lys Glu Phe
         115                 120                 125

 ctt cct ttc ctc tct gat tct tgc tgt act ttg cac caa ctg tat ctt      432
 Leu Pro Phe Leu Ser Asp Ser Cys Cys Thr Leu His Gln Leu Tyr Leu
     130                 135                 140

 cag ata cac agc aag ttt cct cca agc ctt tat gct acc agg att tct      480
 Gln Ile His Ser Lys Phe Pro Pro Ser Leu Tyr Ala Thr Arg Ile Ser
 145                 150                 155                 160

 aaa gca cac caa gag gaa ata gca ggt gct ttc cta gtg aca ctg gat      528
 Lys Ala His Gln Glu Glu Ile Ala Gly Ala Phe Leu Val Thr Leu Asp
                 165                 170                 175

 cca ctt atc agt cag ctg ctc aca ttt cag cct ttc atg cag gtg gtt      576
 Pro Leu Ile Ser Gln Leu Leu Thr Phe Gln Pro Phe Met Gln Val Val
             180                 185                 190

 ttg gac agt aaa tta tac ctg cca tgt gaa ctg cag ttt cca caa tgt      624
 Leu Asp Ser Lys Leu Tyr Leu Pro Cys Glu Leu Gln Phe Pro Gln Cys
         195                 200                 205

 ctt ctt ctg gtt gtt gtc atg gat aag ctg cca tct cag cct aag gaa      672
 Leu Leu Leu Val Val Val Met Asp Lys Leu Pro Ser Gln Pro Lys Glu
     210                 215                 220

 gtg caa acc ctg tgg tgc aca gac agc cag gtc tca gaa acg aca acc      720
 Val Gln Thr Leu Trp Cys Thr Asp Ser Gln Val Ser Glu Thr Thr Thr
 225                 230                 235                 240

 agg ata tct cta ctc aaa gcc gtt ttc tac agt ttt gag cag tgt tct      768
 Arg Ile Ser Leu Leu Lys Ala Val Phe Tyr Ser Phe Glu Gln Cys Ser
                 245                 250                 255

 ggt gaa ctc tct cta cct gtt cat tta cag gga tta aag agt aag ggg      816
 Gly Glu Leu Ser Leu Pro Val His Leu Gln Gly Leu Lys Ser Lys Gly
             260                 265                 270

 aaa gct gag gtg gct gtc acc ttg tat cag cat gtt tgt gtt cat ctg      864
 Lys Ala Glu Val Ala Val Thr Leu Tyr Gln His Val Cys Val His Leu
         275                 280                 285

 tgt aca ttt att act tcc ttt cat ccc tca ctg ttt gct gaa ctg gat      912
 Cys Thr Phe Ile Thr Ser Phe His Pro Ser Leu Phe Ala Glu Leu Asp
     290                 295                 300

 gct gct ctg ctg aat gct gta ctt agt gct aat atg atc acc tct ttg      960
 Ala Ala Leu Leu Asn Ala Val Leu Ser Ala Asn Met Ile Thr Ser Leu
 305                 310                 315                 320

 tta gct atg gat gca tgg tgc ttc ctt gct cga tat ggg act gct gaa     1008
 Leu Ala Met Asp Ala Trp Cys Phe Leu Ala Arg Tyr Gly Thr Ala Glu
                 325                 330                 335

 ctg tgt gca cac cat gtc acc ata gtg gct cat ctg ata aag tca tgc     1056
 Leu Cys Ala His His Val Thr Ile Val Ala His Leu Ile Lys Ser Cys
             340                 345                 350

 cct gga gaa tgt tat caa ctc atc aac cta tca ata ctg ttg aag cgt     1104
 Pro Gly Glu Cys Tyr Gln Leu Ile Asn Leu Ser Ile Leu Leu Lys Arg
         355                 360                 365

 ctc ttt ttc ttc atg gca cca ccc cat cag ctg gag ttt atc cag aaa     1152
 Leu Phe Phe Phe Met Ala Pro Pro His Gln Leu Glu Phe Ile Gln Lys
     370                 375                 380

 ttt tcc cca aaa gaa gca gaa aat ctg cct ctg tgg caa cat att tcc     1200
 Phe Ser Pro Lys Glu Ala Glu Asn Leu Pro Leu Trp Gln His Ile Ser
 385                 390                 395                 400

 ttc cag gcg tta cct cct gag ctt agg gaa caa act gtc cat gag gtc     1248
 Phe Gln Ala Leu Pro Pro Glu Leu Arg Glu Gln Thr Val His Glu Val
                 405                 410                 415

 acc aca gta ggc act gca gaa tgc agg aaa tgg ctg agc agg agt cgt     1296
 Thr Thr Val Gly Thr Ala Glu Cys Arg Lys Trp Leu Ser Arg Ser Arg
             420                 425                 430

 act ttg gga gaa cta gaa tct ctg aac aca gta ctg tct gct ttg ctt     1344
 Thr Leu Gly Glu Leu Glu Ser Leu Asn Thr Val Leu Ser Ala Leu Leu
         435                 440                 445

 gca gta tgt aat tct gct ggt gaa gct ttg gat aca gga aaa caa act     1392
 Ala Val Cys Asn Ser Ala Gly Glu Ala Leu Asp Thr Gly Lys Gln Thr
     450                 455                 460

 gca att atc gaa gtt gtg agt cag ctt tgg gct ttt tta aac att aaa     1440
 Ala Ile Ile Glu Val Val Ser Gln Leu Trp Ala Phe Leu Asn Ile Lys
 465                 470                 475                 480

 cag gta gca gat caa cct tat gtt caa cag aca ttc agc ctt tta ctt     1488
 Gln Val Ala Asp Gln Pro Tyr Val Gln Gln Thr Phe Ser Leu Leu Leu
                 485                 490                 495

 cca ctg ttg gga ttt ttc att caa act cta gat cct aaa ctg ata ctt     1536
 Pro Leu Leu Gly Phe Phe Ile Gln Thr Leu Asp Pro Lys Leu Ile Leu
             500                 505                 510

 cag gca gta act ttg cag acc tcg cta ctt aaa tta gag ctt cct gac     1584
 Gln Ala Val Thr Leu Gln Thr Ser Leu Leu Lys Leu Glu Leu Pro Asp
         515                 520                 525

 tat gtt cgt ttg gca atg ttg gat ttt gta tct tct tta gga aaa ctt     1632
 Tyr Val Arg Leu Ala Met Leu Asp Phe Val Ser Ser Leu Gly Lys Leu
     530                 535                 540

 ttt ata cct gaa gct atc cag gac aga att ctg ccc aac ctg tcc tgt     1680
 Phe Ile Pro Glu Ala Ile Gln Asp Arg Ile Leu Pro Asn Leu Ser Cys
 545                 550                 555                 560

 atg ttt gcc tta ctg cta gct gac agg agt tgg ctg cta gaa caa cat     1728
 Met Phe Ala Leu Leu Leu Ala Asp Arg Ser Trp Leu Leu Glu Gln His
                 565                 570                 575

 acc ttg gag gcg ttt act cag ttc gct gag gga aca aat cat gaa gag     1776
 Thr Leu Glu Ala Phe Thr Gln Phe Ala Glu Gly Thr Asn His Glu Glu
             580                 585                 590

 ata gtt cca cag tgt ctc agt tct gaa gaa act aag aac aaa gtt gta     1824
 Ile Val Pro Gln Cys Leu Ser Ser Glu Glu Thr Lys Asn Lys Val Val
         595                 600                 605

 tcc ttt ctg gag aag act ggg ttt gta gat gaa act gaa gct gcc aaa     1872
 Ser Phe Leu Glu Lys Thr Gly Phe Val Asp Glu Thr Glu Ala Ala Lys
     610                 615                 620

 gtg gaa cgt gtg aaa cag gaa aaa ggt att ttc tgg gaa ccc ttt gct     1920
 Val Glu Arg Val Lys Gln Glu Lys Gly Ile Phe Trp Glu Pro Phe Ala
 625                 630                 635                 640

 aat gtg act gta gaa gaa gca aag agg tca tct tta cag cct tat gca     1968
 Asn Val Thr Val Glu Glu Ala Lys Arg Ser Ser Leu Gln Pro Tyr Ala
                 645                 650                 655

 aaa aga gct cgt cag gag ttc ccc tgg gaa gaa gag tac agg tca gcg     2016
 Lys Arg Ala Arg Gln Glu Phe Pro Trp Glu Glu Glu Tyr Arg Ser Ala
             660                 665                 670

 ctg cat aca ata gca ggg gct ttg gaa gca act gag tca cta ctc caa     2064
 Leu His Thr Ile Ala Gly Ala Leu Glu Ala Thr Glu Ser Leu Leu Gln
         675                 680                 685

 aag ggt cct gct cca gcc tgg ctt tca atg gaa atg gag gcg ctc caa     2112
 Lys Gly Pro Ala Pro Ala Trp Leu Ser Met Glu Met Glu Ala Leu Gln
     690                 695                 700

 gaa agg atg gat aag cta aaa cgt tac ata cat act cta ggg tga aac     2160
 Glu Arg Met Asp Lys Leu Lys Arg Tyr Ile His Thr Leu Gly 
 705                 710                 715

 ttatcactag gcagaactgg gtttgatgct ttgtcaactg aaaatactta tgtctgtaca   2220

 ttttctaaca gatataaaac aaattttgta aagttaaaaa aaaaa                   2265




      <210> 556
      <211> 3694
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (434)..(3694)

      <400> 556
 cgggcgttcc caccgtccct ctccccttac tggcagagct gcgggcggat tcccgggccc     60

 ggagcagccc accggccacc ccaccgccca cccggctccc ggtgtctcct cccggccgct    120

 ctacccagca actttccgtg ctttgttccc cgactggaaa tgctttacgg aagcgtcttg    180

 gacagggtct ccgccaggcg acaagagctc ggtgctgaga tgtgttacgt tctcatctcc    240

 ccatcaatta tggatggaaa caaataagga agagtcaatt ctgctgagcc ccttctccgg    300

 caacgagagg cgttctgcag ccgggaggga gccgccgctc gcgccggcag ccgctggcag    360

 gggcatggtg aggaggaagg tagctcagtg gcatttctga gcaggggcca ccctgacttc    420

 accttggccc acc   atg agg gtc ttc ctg ctt tgt gcc tac ata ctg ctg     469
                  Met Arg Val Phe Leu Leu Cys Ala Tyr Ile Leu Leu
                    1               5                  10

 ctg atg gtt tcc cag ttg agg gca gtc agc ttt cct gaa gat gat gaa      517
 Leu Met Val Ser Gln Leu Arg Ala Val Ser Phe Pro Glu Asp Asp Glu
          15                  20                  25

 ccc ctt aat act gtc gac tat cac tat tca agg caa tat ccg gtt ttt      565
 Pro Leu Asn Thr Val Asp Tyr His Tyr Ser Arg Gln Tyr Pro Val Phe
      30                  35                  40

 aga gga cgc cct tca ggc aat gaa tcg cag cac agg ctg gac ttt cag      613
 Arg Gly Arg Pro Ser Gly Asn Glu Ser Gln His Arg Leu Asp Phe Gln
  45                  50                  55                  60

 ctg atg ttg aaa att cga gac aca ctt tat att gct ggc agg gat caa      661
 Leu Met Leu Lys Ile Arg Asp Thr Leu Tyr Ile Ala Gly Arg Asp Gln
                  65                  70                  75

 gtt tat aca gta aac tta aat gaa atg ccc aaa aca gaa gta ata ccc      709
 Val Tyr Thr Val Asn Leu Asn Glu Met Pro Lys Thr Glu Val Ile Pro
              80                  85                  90

 aac aag aaa ctg aca tgg cga tca aga caa cag gat cga gaa aac tgt      757
 Asn Lys Lys Leu Thr Trp Arg Ser Arg Gln Gln Asp Arg Glu Asn Cys
          95                 100                 105

 gct atg aaa ggc aag cat aaa gat gaa tgc cac aac ttt atc aaa gta      805
 Ala Met Lys Gly Lys His Lys Asp Glu Cys His Asn Phe Ile Lys Val
     110                 115                 120

 ttt gtt cca aga aac gat gag atg gtt ttt gtt tgt ggt acc aat gca      853
 Phe Val Pro Arg Asn Asp Glu Met Val Phe Val Cys Gly Thr Asn Ala
 125                 130                 135                 140

 ttc aat ccc atg tgt aga tac tac agg ttg agt acc tta gaa tat gat      901
 Phe Asn Pro Met Cys Arg Tyr Tyr Arg Leu Ser Thr Leu Glu Tyr Asp
                 145                 150                 155

 ggg gaa gaa att agt ggc ctg gca aga tgc cca ttt gat gcc aga caa      949
 Gly Glu Glu Ile Ser Gly Leu Ala Arg Cys Pro Phe Asp Ala Arg Gln
             160                 165                 170

 acc aat gtt gcc ctc ttt gct gat ggg aag ctg tat tct gcc aca gtg      997
 Thr Asn Val Ala Leu Phe Ala Asp Gly Lys Leu Tyr Ser Ala Thr Val
         175                 180                 185

 gct gac ttc ttg gcc agc gat gcc gtt att tat cga agc atg ggt gat     1045
 Ala Asp Phe Leu Ala Ser Asp Ala Val Ile Tyr Arg Ser Met Gly Asp
     190                 195                 200

 gga tct gcc ctt cgc aca ata aaa tat gat tcc aaa tgg ata aaa gag     1093
 Gly Ser Ala Leu Arg Thr Ile Lys Tyr Asp Ser Lys Trp Ile Lys Glu
 205                 210                 215                 220

 cca cac ttt ctt cat gcc ata gaa tat gga aac tat gtc tat ttc ttc     1141
 Pro His Phe Leu His Ala Ile Glu Tyr Gly Asn Tyr Val Tyr Phe Phe
                 225                 230                 235

 ttt cga gaa atc gct gtc gaa cat aat aat tta ggc aag gct gtg tat     1189
 Phe Arg Glu Ile Ala Val Glu His Asn Asn Leu Gly Lys Ala Val Tyr
             240                 245                 250

 tcc cgc gtg gcc cgc ata tgt aaa aac gac atg ggt ggt tcc cag cgg     1237
 Ser Arg Val Ala Arg Ile Cys Lys Asn Asp Met Gly Gly Ser Gln Arg
         255                 260                 265

 gtc ctg gag aaa cac tgg act tca ttt cta aag gct cgg ctg aac tgt     1285
 Val Leu Glu Lys His Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys
     270                 275                 280

 tct gtc cct gga gat ccg ttt ttc tac ttt gat gtt ctg cag tct att     1333
 Ser Val Pro Gly Asp Pro Phe Phe Tyr Phe Asp Val Leu Gln Ser Ile
 285                 290                 295                 300

 aca gac ata ata caa atc aat ggc atc ccc act gtg gtc ggg gtg ttt     1381
 Thr Asp Ile Ile Gln Ile Asn Gly Ile Pro Thr Val Val Gly Val Phe
                 305                 310                 315

 acc acg cag ctc aat agc atc cct ggt tct gct gtc tgt gca ttt agc     1429
 Thr Thr Gln Leu Asn Ser Ile Pro Gly Ser Ala Val Cys Ala Phe Ser
             320                 325                 330

 atg gat gac att gaa aaa gta ttc aaa gga cgg ttt aag gaa cag aaa     1477
 Met Asp Asp Ile Glu Lys Val Phe Lys Gly Arg Phe Lys Glu Gln Lys
         335                 340                 345

 act cca gat tct gtt tgg aca gca gtt ccc gaa gac aaa gtg cca aag     1525
 Thr Pro Asp Ser Val Trp Thr Ala Val Pro Glu Asp Lys Val Pro Lys
     350                 355                 360

 cca agg cct ggc tgt tgt gca aaa cac ggc ctt gcc gaa gct tat aaa     1573
 Pro Arg Pro Gly Cys Cys Ala Lys His Gly Leu Ala Glu Ala Tyr Lys
 365                 370                 375                 380

 acc tcc atc gat ttc ccg gat gaa act ctg tca ttc atc aaa tct cat     1621
 Thr Ser Ile Asp Phe Pro Asp Glu Thr Leu Ser Phe Ile Lys Ser His
                 385                 390                 395

 ccc ctg atg gac tct gcc gtt cca ccc att gcc gat gag ccc tgg ttc     1669
 Pro Leu Met Asp Ser Ala Val Pro Pro Ile Ala Asp Glu Pro Trp Phe
             400                 405                 410

 aca aag act cgg gtc agg tac aga ctg acg gcc atc tca gtg gac cat     1717
 Thr Lys Thr Arg Val Arg Tyr Arg Leu Thr Ala Ile Ser Val Asp His
         415                 420                 425

 tca gcc gga ccc tac cag aac tac aca gtc atc ttt gtt ggc tct gaa     1765
 Ser Ala Gly Pro Tyr Gln Asn Tyr Thr Val Ile Phe Val Gly Ser Glu
     430                 435                 440

 gct ggc atg gta ctt aaa gtt ctg gca aag acc agt cct ttc tct ttg     1813
 Ala Gly Met Val Leu Lys Val Leu Ala Lys Thr Ser Pro Phe Ser Leu
 445                 450                 455                 460

 aac gac agc gta tta ctg gaa gag att gaa gcc tac aac cat gca aag     1861
 Asn Asp Ser Val Leu Leu Glu Glu Ile Glu Ala Tyr Asn His Ala Lys
                 465                 470                 475

 tgc agt gct gag aat gag gaa gac aaa aag gtc atc tca tta cag ttg     1909
 Cys Ser Ala Glu Asn Glu Glu Asp Lys Lys Val Ile Ser Leu Gln Leu
             480                 485                 490

 gat aaa gat cac cac gct tta tat gtg gcg ttc tct agc tgc att atc     1957
 Asp Lys Asp His His Ala Leu Tyr Val Ala Phe Ser Ser Cys Ile Ile
         495                 500                 505

 cgc atc ccc ctc agt cgc tgt gag cgt tat gga tca tgt aaa aag tct     2005
 Arg Ile Pro Leu Ser Arg Cys Glu Arg Tyr Gly Ser Cys Lys Lys Ser
     510                 515                 520

 tgt att gca tct cgt gac ccg tat tgt ggc tgg tta agc cag gga tcc     2053
 Cys Ile Ala Ser Arg Asp Pro Tyr Cys Gly Trp Leu Ser Gln Gly Ser
 525                 530                 535                 540

 tgt ggt aga gtg acc cca ggg atg ctg ctg tta acc gaa gac ttc ttt     2101
 Cys Gly Arg Val Thr Pro Gly Met Leu Leu Leu Thr Glu Asp Phe Phe
                 545                 550                 555

 gct ttc cat aac cac agt gct gaa gga tat gaa caa gac aca gaa ttc     2149
 Ala Phe His Asn His Ser Ala Glu Gly Tyr Glu Gln Asp Thr Glu Phe
             560                 565                 570

 ggc aac aca gct cat cta ggg gac tgc cat gaa att ttg cct act tca     2197
 Gly Asn Thr Ala His Leu Gly Asp Cys His Glu Ile Leu Pro Thr Ser
         575                 580                 585

 act aca cca gat tac aaa ata ttt ggc ggt cca aca tct gac atg gag     2245
 Thr Thr Pro Asp Tyr Lys Ile Phe Gly Gly Pro Thr Ser Asp Met Glu
     590                 595                 600

 gta tct tca tct tct gtt acc aca atg gca agt atc cca gaa atc aca     2293
 Val Ser Ser Ser Ser Val Thr Thr Met Ala Ser Ile Pro Glu Ile Thr
 605                 610                 615                 620

 cct aaa gtg att gat acc tgg aga cct aaa ctg aca agc tct cgg aaa     2341
 Pro Lys Val Ile Asp Thr Trp Arg Pro Lys Leu Thr Ser Ser Arg Lys
                 625                 630                 635

 ttt gta gtt caa gat gat cca aac act tct gat ttt act gat cct tta     2389
 Phe Val Val Gln Asp Asp Pro Asn Thr Ser Asp Phe Thr Asp Pro Leu
             640                 645                 650

 tcg ggt atc cca aag ggt gta cga tgg gaa gtc cag tct gga gag tcc     2437
 Ser Gly Ile Pro Lys Gly Val Arg Trp Glu Val Gln Ser Gly Glu Ser
         655                 660                 665

 aac cag atg gtc cac atg aat gtc ctc atc acc tgt gtc ttt gct gct     2485
 Asn Gln Met Val His Met Asn Val Leu Ile Thr Cys Val Phe Ala Ala
     670                 675                 680

 ttt gtc ttg ggg gca ttc att gca ggt gtg gca gta tac tgc tat cga     2533
 Phe Val Leu Gly Ala Phe Ile Ala Gly Val Ala Val Tyr Cys Tyr Arg
 685                 690                 695                 700

 gac atg ttt gtt cgg aaa aac aga aag atc cat aaa gat gca gag tcc     2581
 Asp Met Phe Val Arg Lys Asn Arg Lys Ile His Lys Asp Ala Glu Ser
                 705                 710                 715

 gcc cag tca tgc aca gac tcc agt gga agt ttt gcc aaa ctg aat ggt     2629
 Ala Gln Ser Cys Thr Asp Ser Ser Gly Ser Phe Ala Lys Leu Asn Gly
             720                 725                 730

 ctc ttt gac agc cct gtc aag gaa tac caa cag aat att gat tct cct     2677
 Leu Phe Asp Ser Pro Val Lys Glu Tyr Gln Gln Asn Ile Asp Ser Pro
         735                 740                 745

 aaa ctg tat agt aac ctg cta acc agt cgg aaa gag cta cca ccc aat     2725
 Lys Leu Tyr Ser Asn Leu Leu Thr Ser Arg Lys Glu Leu Pro Pro Asn
     750                 755                 760

 gga gat act aaa tcc atg gta atg gac cat cga ggg caa cct cca gag     2773
 Gly Asp Thr Lys Ser Met Val Met Asp His Arg Gly Gln Pro Pro Glu
 765                 770                 775                 780

 ttg gct gct ctt ccc act cct gag tct aca ccc gtg ctt cac cag aag     2821
 Leu Ala Ala Leu Pro Thr Pro Glu Ser Thr Pro Val Leu His Gln Lys
                 785                 790                 795

 acc ctg cag gcc atg aag agc cac tca gaa aag gcc cat ggc cat gga     2869
 Thr Leu Gln Ala Met Lys Ser His Ser Glu Lys Ala His Gly His Gly
             800                 805                 810

 gct tca agg aaa gaa acc cct cag ttt ttt ccg tct agt ccg cca cct     2917
 Ala Ser Arg Lys Glu Thr Pro Gln Phe Phe Pro Ser Ser Pro Pro Pro
         815                 820                 825

 cat tcc cca tta agt cat ggg cat atc ccc agt gcc att gtt ctt cca     2965
 His Ser Pro Leu Ser His Gly His Ile Pro Ser Ala Ile Val Leu Pro
     830                 835                 840

 aat gct acc cat gac tac aac acg tct ttc tca aac tcc aat gct cac     3013
 Asn Ala Thr His Asp Tyr Asn Thr Ser Phe Ser Asn Ser Asn Ala His
 845                 850                 855                 860

 aaa gct gaa aag aag ctt caa aac att gat cac cct ctc aca aag tca     3061
 Lys Ala Glu Lys Lys Leu Gln Asn Ile Asp His Pro Leu Thr Lys Ser
                 865                 870                 875

 tcc agt aag aga gat cac cgg cgt tct gtt gat tcc aga aat acc ctc     3109
 Ser Ser Lys Arg Asp His Arg Arg Ser Val Asp Ser Arg Asn Thr Leu
             880                 885                 890

 aat gat ctc ctg aag cat ctg aat gac cca aat agt aac ccc aaa gcc     3157
 Asn Asp Leu Leu Lys His Leu Asn Asp Pro Asn Ser Asn Pro Lys Ala
         895                 900                 905

 atc atg gga gac atc cag atg gca cac cag aac tta atg ctg gat ccc     3205
 Ile Met Gly Asp Ile Gln Met Ala His Gln Asn Leu Met Leu Asp Pro
     910                 915                 920

 atg gga tcg atg tct gag gtc cca cct aaa gtc cct aac cgg gag gca     3253
 Met Gly Ser Met Ser Glu Val Pro Pro Lys Val Pro Asn Arg Glu Ala
 925                 930                 935                 940

 tcg cta tac tcc cct cct tca act ctc ccc aga aat agc cca acc aag     3301
 Ser Leu Tyr Ser Pro Pro Ser Thr Leu Pro Arg Asn Ser Pro Thr Lys
                 945                 950                 955

 cga gtg gat gtc ccc acc act cct gga gtc cca atg act tct ctg gaa     3349
 Arg Val Asp Val Pro Thr Thr Pro Gly Val Pro Met Thr Ser Leu Glu
             960                 965                 970

 aga caa aga ggt tat cac aaa aat tcc tcc cag agg cac tct ata tct     3397
 Arg Gln Arg Gly Tyr His Lys Asn Ser Ser Gln Arg His Ser Ile Ser
         975                 980                 985

 gct atg cct aaa aac tta aac tca cca aat ggt gtt ttg tta tcc aga     3445
 Ala Met Pro Lys Asn Leu Asn Ser Pro Asn Gly Val Leu Leu Ser Arg
     990                 995                1000

 cag cct agt atg aac cgt gga gga tat atg ccc acc ccc act ggg gcg     3493
 Gln Pro Ser Met Asn Arg Gly Gly Tyr Met Pro Thr Pro Thr Gly Ala
1005                1010                1015                1020

 aag gtg gac tat att cag gga aca cca gtg agt gtt cat ctg cag cct     3541
 Lys Val Asp Tyr Ile Gln Gly Thr Pro Val Ser Val His Leu Gln Pro
                1025                1030                1035

 tcc ctc tcc aga cag agc agc tac acc agt aat ggc act ctt cct agg     3589
 Ser Leu Ser Arg Gln Ser Ser Tyr Thr Ser Asn Gly Thr Leu Pro Arg
            1040                1045                1050

 acg gga cta aag agg acg ccg tcc tta aaa cct gac gtg cca cca aag     3637
 Thr Gly Leu Lys Arg Thr Pro Ser Leu Lys Pro Asp Val Pro Pro Lys
        1055                1060                1065

 cct tcc ttt gtt cct caa acc cca tct gtc aga cca ctg aac aaa tac     3685
 Pro Ser Phe Val Pro Gln Thr Pro Ser Val Arg Pro Leu Asn Lys Tyr
    1070                1075                1080

 aca tac tag                                                         3694
 Thr Tyr 
1085





      <210> 557
      <211> 501
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(351)

      <400> 557
 tttcttataa tgccaacttt gtacaagaaa gctgggtcgg cgcgcccacc cttcacc        57                                                                 
 atg cag tgc tgc ctg ctg ctg cgc tgg ctg gca tct gcc ctc ctc cgt      105
 Met Gln Cys Cys Leu Leu Leu Arg Trp Leu Ala Ser Ala Leu Leu Arg
   1               5                  10                  15

 ctc ctg ggt gtt gcc aca gag aag aga gag aga gtg aag cgg gca gag      153
 Leu Leu Gly Val Ala Thr Glu Lys Arg Glu Arg Val Lys Arg Ala Glu
              20                  25                  30

 act ggc tgt tgc cat cac aca act gag ggc gga cct gga gct cag ccg      201
 Thr Gly Cys Cys His His Thr Thr Glu Gly Gly Pro Gly Ala Gln Pro
          35                  40                  45

 gct gag ggt ttg aga gac cgt tgg gag caa gag cca acc aca agg ccc      249
 Ala Glu Gly Leu Arg Asp Arg Trp Glu Gln Glu Pro Thr Thr Arg Pro
      50                  55                  60

 atg gaa gag gaa gtt ggc aga tct cag aaa ggg gag gaa aag gag agg      297
 Met Glu Glu Glu Val Gly Arg Ser Gln Lys Gly Glu Glu Lys Glu Arg
  65                  70                  75                  80

 tgc tta ttt gtt cat ctt gtt ttt gct ttt aag gaa agg agg aga gtt      345
 Cys Leu Phe Val His Leu Val Phe Ala Phe Lys Glu Arg Arg Arg Val
                  85                  90                  95

 aaa tga gaaaggaggg cgagttgaga aggttctgag cagtttcagg tccacggttg       401
 Lys 


 agcaatgttc ttcctggaca acaaactgcc tggatttcat tttggtcaag ggggcgcgcg    461

 cggaacctgc tttcttgtac aaagttggca ttataaaaaa                          501




      <210> 558
      <211> 810
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (445)..(621)

      <400> 558
 gcggacagcg gagccaagct gacccggcga gcggagccgg ggctggagag cggcgaccac     60

 tgcggatctc ggaaggaaga aatgatgtaa atcactcatc caaactttaa ggtcaaaggt    120

 gagaaggaag gtcaggaaga acatggcctg gccaaatgtt tttcaaagag ggtctctgct    180

 gtcccagttc agccatcatc atgttgtagt gttcctgctc actttcttca gttattcgtt    240

 gctccatgct tcacgaaaaa catttagcaa tgtcaaagtc agtatctctg agcagtggac    300

 cccaagtgct tttaacacgt cagttgagct gcctctggag gtaagcagaa cagagtgctg    360

 ggatggatcg aagtaggaga ccgtgcccac ccctagattg ttcttaagct cttttttgca    420

 tcttttactt gcctagactc tgaa   atg gct cac tgt ttc cta tca cat aag     471
                              Met Ala His Cys Phe Leu Ser His Lys
                                1               5

 agc caa act att cta att tca aag cct gct ctg act cag tcc cat ttt      519
 Ser Gln Thr Ile Leu Ile Ser Lys Pro Ala Leu Thr Gln Ser His Phe
  10                  15                  20                  25

 acc tct cca gcc ggc ttg ttt cta act gtt gag aaa tca cac ctt ttg      567
 Thr Ser Pro Ala Gly Leu Phe Leu Thr Val Glu Lys Ser His Leu Leu
                  30                  35                  40

 aca agg ctg ttt ttt cac tgg ctt tcg tta gtg ctg tgc tcg ctt act      615
 Thr Arg Leu Phe Phe His Trp Leu Ser Leu Val Leu Cys Ser Leu Thr
              45                  50                  55

 gag taa gcggagcatc agtaagcggt tcagtaacgg agcatcagta agcatcagta       671
 Glu 


 accggagcat cagtaagcgg agcggtcacg cctgctgggg gtatgttgtg ttggaagaag    731

 aggaggcgag gaggtggcat agatctgccc gcttactgat gctccgctta ctgatgctcc    791

 gcttactgac gcttactga                                                 810




      <210> 559
      <211> 781
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(714)

      <400> 559
 ggg  atg gcg gag ttg gta cct ttt gcg gtt ccc atc gag agt gac aaa      48
      Met Ala Glu Leu Val Pro Phe Ala Val Pro Ile Glu Ser Asp Lys
        1               5                  10                  15

 acc ttg cta gtg tgg gag ctg agc tcc gga ccc acg gcc gag gct ttg       96
 Thr Leu Leu Val Trp Glu Leu Ser Ser Gly Pro Thr Ala Glu Ala Leu
                  20                  25                  30

 cat cat tct ctg ttc aca gca ttt tct cag ttt ggc ctt ctg tat tca      144
 His His Ser Leu Phe Thr Ala Phe Ser Gln Phe Gly Leu Leu Tyr Ser
              35                  40                  45

 gtc cgg gtc ttc cca aat gct gca gtg gcc cat cct ggt ttc tat gcc      192
 Val Arg Val Phe Pro Asn Ala Ala Val Ala His Pro Gly Phe Tyr Ala
          50                  55                  60

 gtc att aag ttt tat tct gca agg gct gcc cac aga gcc caa aag gca      240
 Val Ile Lys Phe Tyr Ser Ala Arg Ala Ala His Arg Ala Gln Lys Ala
      65                  70                  75

 tgc gac cgg aag cag ctt ttt cag aaa tct cca gtc aag gtt cgt ctt      288
 Cys Asp Arg Lys Gln Leu Phe Gln Lys Ser Pro Val Lys Val Arg Leu
  80                  85                  90                  95

 ggc acc aga cat aag gca gtt caa cat caa gcc ctt gcc ctg aac agt      336
 Gly Thr Arg His Lys Ala Val Gln His Gln Ala Leu Ala Leu Asn Ser
                 100                 105                 110

 tcc aaa tgc caa gaa ctg gcg aat tac tac ttt ggt ttc aat ggg tgt      384
 Ser Lys Cys Gln Glu Leu Ala Asn Tyr Tyr Phe Gly Phe Asn Gly Cys
             115                 120                 125

 tcc aaa agg atc atc aag ctt cag gag ctt tct gac ctt gaa gaa agg      432
 Ser Lys Arg Ile Ile Lys Leu Gln Glu Leu Ser Asp Leu Glu Glu Arg
         130                 135                 140

 gaa aat gaa gat agc atg gtg cca ctt ccg aag caa agc ctg aag ttc      480
 Glu Asn Glu Asp Ser Met Val Pro Leu Pro Lys Gln Ser Leu Lys Phe
     145                 150                 155

 ttc tgt gct tta gaa gtg gtg ttg cca tcc tgt gat tgc agg agt cct      528
 Phe Cys Ala Leu Glu Val Val Leu Pro Ser Cys Asp Cys Arg Ser Pro
 160                 165                 170                 175

 ggc att ggc ttg gtg gag gag cct atg gat aag gtg gag gaa gga cca      576
 Gly Ile Gly Leu Val Glu Glu Pro Met Asp Lys Val Glu Glu Gly Pro
                 180                 185                 190

 tta tca ttc ctt atg aaa agg aag aca gcc cag aag ctt gct att cag      624
 Leu Ser Phe Leu Met Lys Arg Lys Thr Ala Gln Lys Leu Ala Ile Gln
             195                 200                 205

 aag gct ttg tca gat gca ttc cag aaa ctg ttg att gtt gtt cta ggt      672
 Lys Ala Leu Ser Asp Ala Phe Gln Lys Leu Leu Ile Val Val Leu Gly
         210                 215                 220

 aag act gtc ttg atc atc ctt gaa gta ctt cag ttt cag taa gcaaata      721
 Lys Thr Val Leu Ile Ile Leu Glu Val Leu Gln Phe Gln 
     225                 230                 235

 aactcatttt gaaaagttaa ttgaataaaa atattgatat ctaaagcaaa aaaaaaaaaa    781




      <210> 560
      <211> 874
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (304)..(687)

      <400> 560
 gaaaccagct gctgaaagct ggcggggtgg gtctcagcac ttcaggtggc ataataaaat     60

 aagaaggaat gactcatgct gggacaccga tggcccgtga aaacatcatg ctaggtgaag    120

 ggagccggag atgaaaggcc acattcggat gtctgcctga gccccacccc gaatgccagg    180

 ccttcttccc tgagcgtcac cctagcccca gctccaggac tgagagcccc aggaagcttg    240

 gagaggtgtg agagagacag gtgtccagtc ctcagccccg atccttcacc tgcagagccc    300

 ggc  atg tgg ggc tac ctg tcg ctg atg cct gtc ttc cta gct gtc tgg     348
      Met Trp Gly Tyr Leu Ser Leu Met Pro Val Phe Leu Ala Val Trp
        1               5                  10                  15

 gct atc tct ggc gtc tgg atc gtt ttt gcc att gcg gtg acc aac agg      396
 Ala Ile Ser Gly Val Trp Ile Val Phe Ala Ile Ala Val Thr Asn Arg
                  20                  25                  30

 act gtg gac ctc agt aaa ggc ttt ccc tac atc agc atc tgc gga tcc      444
 Thr Val Asp Leu Ser Lys Gly Phe Pro Tyr Ile Ser Ile Cys Gly Ser
              35                  40                  45

 ttc ccc cct cag agc tgc atc ttc agc cag gtg ctc aat atg gga gct      492
 Phe Pro Pro Gln Ser Cys Ile Phe Ser Gln Val Leu Asn Met Gly Ala
          50                  55                  60

 gct ctg gcc gcg tgg atc tgc att gtc cgt tac cac cag ctc cgg gac      540
 Ala Leu Ala Ala Trp Ile Cys Ile Val Arg Tyr His Gln Leu Arg Asp
      65                  70                  75

 tgg ggc gtc aga agg tgg cct aac cag ctg atc cta tgg acg ggt ctt      588
 Trp Gly Val Arg Arg Trp Pro Asn Gln Leu Ile Leu Trp Thr Gly Leu
  80                  85                  90                  95

 ctg tgt gcc ctg ggc acc tcc cgt ggt agg caa ttt cca gga aaa gaa      636
 Leu Cys Ala Leu Gly Thr Ser Arg Gly Arg Gln Phe Pro Gly Lys Glu
                 100                 105                 110

 cca gcg gcc tac gca ctt ggc agg ggc ctt cct tgc ctt cat ctt ggg      684
 Pro Ala Ala Tyr Ala Leu Gly Arg Gly Leu Pro Cys Leu His Leu Gly
             115                 120                 125

 taa cgtc tacttatggc tgcagctcct cctgtggagg ctgaagaggc tgccccagcc      741
 


 cggggctgcc tggattgggc ccctccgcct gggcctctgc agcgtctgca ccatcctcat    801

 tgtggccatg atcgtcctcc acgcctgctc gctgcgtagc gtctctgcgg cctgcgagtg    861

 ggtcggggcc atg                                                       874




      <210> 561
      <211> 1005
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (304)..(1005)

      <400> 561
 gaaaccagct gctgaaagct ggcggggtgg gtctcagcac ttcaggtggc ataataaaat     60

 aagaaggaat gactcatgct gggacaccga tggcccgtga aaacatcatg ctaggtgaag    120

 ggagccggag atgaaaggcc acattcggat gtctgcctga gccccacccc gaatgccagg    180

 ccttcttccc tgagcgtcac cctagcccca gctccaggac tgagagcccc aggaagcttg    240

 gagaggtgtg agagagacag gtgtccagtc ctcagccccg atccttcacc tgcagagccc    300

 ggc  atg tgg ggc tac ctg tcg ctg atg cct gtc ttc cta gct gtc tgg     348
      Met Trp Gly Tyr Leu Ser Leu Met Pro Val Phe Leu Ala Val Trp
        1               5                  10                  15

 gct atc tct ggc gtc tgg atc gtt ttt gcc att gcg gtg acc aac agg      396
 Ala Ile Ser Gly Val Trp Ile Val Phe Ala Ile Ala Val Thr Asn Arg
                  20                  25                  30

 act gtg gac ctc agt aaa ggc ttt ccc tac atc agc atc tgc gga tcc      444
 Thr Val Asp Leu Ser Lys Gly Phe Pro Tyr Ile Ser Ile Cys Gly Ser
              35                  40                  45

 ttc ccc cct cag agc tgc atc ttc agc cag gtg ctc aat atg gga gct      492
 Phe Pro Pro Gln Ser Cys Ile Phe Ser Gln Val Leu Asn Met Gly Ala
          50                  55                  60

 gct ctg gcc gcg tgg atc tgc att gtc cgt tac cac cag ctc cgg gac      540
 Ala Leu Ala Ala Trp Ile Cys Ile Val Arg Tyr His Gln Leu Arg Asp
      65                  70                  75

 tgg ggc gtc aga agg tgg cct aac cag ctg atc cta tgg acg ggt ctt      588
 Trp Gly Val Arg Arg Trp Pro Asn Gln Leu Ile Leu Trp Thr Gly Leu
  80                  85                  90                  95

 ctg tgt gcc ctg ggc acc tcc gtg gta ggc aat ttc cag gaa aag aac      636
 Leu Cys Ala Leu Gly Thr Ser Val Val Gly Asn Phe Gln Glu Lys Asn
                 100                 105                 110

 cag cgg cct acg cac ttg gca ggg gcc ttc ctt gcc ttc atc ttg ggt      684
 Gln Arg Pro Thr His Leu Ala Gly Ala Phe Leu Ala Phe Ile Leu Gly
             115                 120                 125

 aac gtc tac ttc tgg ctg cag ctc ctc ctg tgg agg ctg aag agg ctg      732
 Asn Val Tyr Phe Trp Leu Gln Leu Leu Leu Trp Arg Leu Lys Arg Leu
         130                 135                 140

 ccc cag ccc ggg gct gcc tgg att ggg ccc ctc cgc ctg ggc ctc tgc      780
 Pro Gln Pro Gly Ala Ala Trp Ile Gly Pro Leu Arg Leu Gly Leu Cys
     145                 150                 155

 agc gtc tgc acc atc ctc att gtg gcc gtg atc gtc ctc cac gcc tgc      828
 Ser Val Cys Thr Ile Leu Ile Val Ala Val Ile Val Leu His Ala Cys
 160                 165                 170                 175

 tcg ctg cgt agc gtc tct gcg gcc tgc gag tgg gtc gtg gcc atg ctg      876
 Ser Leu Arg Ser Val Ser Ala Ala Cys Glu Trp Val Val Ala Met Leu
                 180                 185                 190

 ctg ttc gcg ctc ttc ggt ctc tta gcc gtt gac ttc tcc gcc ctg gag      924
 Leu Phe Ala Leu Phe Gly Leu Leu Ala Val Asp Phe Ser Ala Leu Glu
             195                 200                 205

 agc tgc acc ctg tgt gtt cag ccg tgg ccc agc ctc agc ccc ccg ccg      972
 Ser Cys Thr Leu Cys Val Gln Pro Trp Pro Ser Leu Ser Pro Pro Pro
         210                 215                 220

 gcc tcc ccc atc tcc ctg ccg gtc cag ctg tag                         1005
 Ala Ser Pro Ile Ser Leu Pro Val Gln Leu 
     225                 230





      <210> 562
      <211> 1291
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (347)..(1039)

      <400> 562
 taaatgaaag caacaggagc tgctccgggg actgcttttg ccagtaccca gaatcagtgc     60

 tcaggctcag aaatcctgga tagaaagagc attttataaa agagaatgtg tccacatcat    120

 acccagcacc aaagaccccc ataggtgttg ctgtgggcgt ctgataggcc agcatgttgg    180

 cctcaccccc agtatctccg tgcttcagaa tgagaaaaat gaaagtcgcc tctcccgaaa    240

 tgacatccag tctgaaaagt ggtccatcag caaacacact caactcagcc ctacggatgc    300

 ttttgggacc attgagttcc aaggaggtgg ccattccaac aaagcc   atg tat gtg     355
                                                      Met Tyr Val
                                                        1

 cga gta tct ttt gat aca aaa cct gat ctc ctc tta cac ctg atg acc      403
 Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr
       5                  10                  15

 aag gaa tgg cag ttg gag ctt ccc aag ctt ctc atc tct gtc cat ggg      451
 Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly
  20                  25                  30                  35

 ggc ctg cag aac ttt gaa ctc cag cca aaa ctc aag caa gtc ttt ggg      499
 Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly
                  40                  45                  50

 aaa ggg ctc atc aaa gca gct atg aca act gga gcg tgg ata ttc act      547
 Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr
              55                  60                  65

 gga ggg gtt aac aca ggt gtt att cgt cat gtt ggc gat gcc ttg aag      595
 Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys
          70                  75                  80

 gat cat gcc tct aag tct cga gga aag ata tgc acc ata ggt att gcc      643
 Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala
      85                  90                  95

 ccc tgg gga att gtg gaa aac cag gag gac ctc att gga aga gat gtt      691
 Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val
 100                 105                 110                 115

 gtc cgg cca tac cag acc atg tcc aat ccc atg agc aag ctc act gtt      739
 Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val
                 120                 125                 130

 ctc aac agc atg cat tcc cac ttc att ctg gct gac aac ggg acc act      787
 Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr
             135                 140                 145

 gga aaa tat gga gca gag gtg aaa ctt cga aga caa ctg gaa aag cat      835
 Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His
         150                 155                 160

 att tca ctc cag aag ata aac aca aga atc ggt caa ggt gtt cct gtg      883
 Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val
     165                 170                 175

 gtg gca ctc ata gtg gaa gga gga ccc aat gtg atc tcg att gtt ttg      931
 Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu
 180                 185                 190                 195

 gag tac ctt cga gac acc cct ccc gtg cca gtg gtt gtc tgt gat ggg      979
 Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly
                 200                 205                 210

 agt gga cgg gca tcg gac atc ctg gcc ttt ggg cat aaa tac tca gaa     1027
 Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu
             215                 220                 225

 gaa ggc ggg tag gta actttccagg ccccatggaa gaaccctaaa gcctgtttgg     1082
 Glu Gly Gly 
         230

 aaacgagggt atgagtggat tatgttttca gtagctcaac caagacctca aatcaaaaca   1142

 agctatgaac aaattgtcta aaaaatgtct gtcatgggag ggctgtggtg aagaacagag   1202

 aaacatattc taaatgtcct gtgaagtggg aaattctatg aaagctacac ggataataaa   1262

 aagggtgagg aaaagagaaa aaaaaaaaa                                     1291




      <210> 563
      <211> 7524
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (204)..(3626)

      <400> 563
 aaagattgct ttcttctggg acgctgcttg gacgctaacc gcgttgattg gaacagattt     60

 tgtgtcttgg ctggctttgg gtgaagaccg gggagaaaag gttgcgctgc gattctcaag    120

 atctctggac ctggattatc attgcaaatc cattaaagaa ggagaagcaa gcggatttca    180

 gagaggttgt tcttcagaaa aaa    atg gtt att tct ttg aac tca tgc ctg     230
                              Met Val Ile Ser Leu Asn Ser Cys Leu
                                1               5

 agc ttt att tgt tta ttg tta tgc cac tgg att ggg aca gca tca cct      278
 Ser Phe Ile Cys Leu Leu Leu Cys His Trp Ile Gly Thr Ala Ser Pro
  10                  15                  20                  25

 ctg aat ctt gaa gac cct aat gtg tgt agc cac tgg gaa agc tac tca      326
 Leu Asn Leu Glu Asp Pro Asn Val Cys Ser His Trp Glu Ser Tyr Ser
                  30                  35                  40

 gtg act gtg caa gag tca tac cca cat ccc ttt gat caa att tac tac      374
 Val Thr Val Gln Glu Ser Tyr Pro His Pro Phe Asp Gln Ile Tyr Tyr
              45                  50                  55

 acg agc tgc act gac att cta aac tgg ttt aaa tgc acg cgg cac aga      422
 Thr Ser Cys Thr Asp Ile Leu Asn Trp Phe Lys Cys Thr Arg His Arg
          60                  65                  70

 gtc agc tat cgg aca gcc tat cga cat ggg gag aag act atg tat agg      470
 Val Ser Tyr Arg Thr Ala Tyr Arg His Gly Glu Lys Thr Met Tyr Arg
      75                  80                  85

 cgc aag tct cag tgt tgt cct gga ttt tat gaa agc ggg gaa atg tgt      518
 Arg Lys Ser Gln Cys Cys Pro Gly Phe Tyr Glu Ser Gly Glu Met Cys
  90                  95                 100                 105

 gtc ccc cac tgt gct gat aaa tgt gtc cat ggt cgc tgt att gct cca      566
 Val Pro His Cys Ala Asp Lys Cys Val His Gly Arg Cys Ile Ala Pro
                 110                 115                 120

 aac acc tgt cag tgt gag cct ggc tgg gga ggg acc aac tgc tcc agt      614
 Asn Thr Cys Gln Cys Glu Pro Gly Trp Gly Gly Thr Asn Cys Ser Ser
             125                 130                 135

 gcc tgc gat ggt gat cac tgg ggt ccc cac tgc acc agc cgg tgc cag      662
 Ala Cys Asp Gly Asp His Trp Gly Pro His Cys Thr Ser Arg Cys Gln
         140                 145                 150

 tgc aaa aat ggg gct ctg tgc aac ccc atc acc ggg gct tgc cac tgt      710
 Cys Lys Asn Gly Ala Leu Cys Asn Pro Ile Thr Gly Ala Cys His Cys
     155                 160                 165

 gct gcg ggc ttc cgg ggc tgg cgc tgc gag gac cgc tgt gag cag ggc      758
 Ala Ala Gly Phe Arg Gly Trp Arg Cys Glu Asp Arg Cys Glu Gln Gly
 170                 175                 180                 185

 acc tat ggt aac gac tgt cat cag aga tgc cag tgc cag aat gga gcc      806
 Thr Tyr Gly Asn Asp Cys His Gln Arg Cys Gln Cys Gln Asn Gly Ala
                 190                 195                 200

 acc tgc gac cac gtc acg ggg gaa tgc cgc tgc cca cca gga tac acc      854
 Thr Cys Asp His Val Thr Gly Glu Cys Arg Cys Pro Pro Gly Tyr Thr
             205                 210                 215

 gga gcc ttc tgt gag gat ctt tgt cct cct ggt aaa cat ggt cca cag      902
 Gly Ala Phe Cys Glu Asp Leu Cys Pro Pro Gly Lys His Gly Pro Gln
         220                 225                 230

 tgt gag cag aga tgc cct tgt caa aat gga gga gtg tgt cat cac gtc      950
 Cys Glu Gln Arg Cys Pro Cys Gln Asn Gly Gly Val Cys His His Val
     235                 240                 245

 act gga gaa tgc tct tgc cct tct ggc tgg atg ggc aca gtg tgt ggt      998
 Thr Gly Glu Cys Ser Cys Pro Ser Gly Trp Met Gly Thr Val Cys Gly
 250                 255                 260                 265

 cag cct tgc ccc gag ggt cgc ttt gga aag aac tgt tcc caa gaa tgc     1046
 Gln Pro Cys Pro Glu Gly Arg Phe Gly Lys Asn Cys Ser Gln Glu Cys
                 270                 275                 280

 cag tgc cat aat gga ggg acg tgt gat gct gcc aca ggc caa tgt cat     1094
 Gln Cys His Asn Gly Gly Thr Cys Asp Ala Ala Thr Gly Gln Cys His
             285                 290                 295

 tgc agt cca gga tac aca ggg gaa cgg tgc cag gat gag tgt cct gtt     1142
 Cys Ser Pro Gly Tyr Thr Gly Glu Arg Cys Gln Asp Glu Cys Pro Val
         300                 305                 310

 ggg acc tat ggc gtt ctc tgt gct gag acc tgc cag tgt gtc aac gga     1190
 Gly Thr Tyr Gly Val Leu Cys Ala Glu Thr Cys Gln Cys Val Asn Gly
     315                 320                 325

 ggg aag tgt tac cac gtg agc ggc gca tgc ctc tgt gaa gca ggc ttt     1238
 Gly Lys Cys Tyr His Val Ser Gly Ala Cys Leu Cys Glu Ala Gly Phe
 330                 335                 340                 345

 gct ggc gag cgc tgc gaa gca cgc ctg tgt cct gag ggg ctc tac ggc     1286
 Ala Gly Glu Arg Cys Glu Ala Arg Leu Cys Pro Glu Gly Leu Tyr Gly
                 350                 355                 360

 atc aaa tgt gac aaa cgg tgt ccc tgc cac ctg gaa aac act cat agc     1334
 Ile Lys Cys Asp Lys Arg Cys Pro Cys His Leu Glu Asn Thr His Ser
             365                 370                 375

 tgt cac ccc atg tct gga gag tgt gcc tgc aag ccg ggc tgg tca gga     1382
 Cys His Pro Met Ser Gly Glu Cys Ala Cys Lys Pro Gly Trp Ser Gly
         380                 385                 390

 ctc tac tgt aat gag aca tgt tct cct gga ttc tac ggg gaa gct tgc     1430
 Leu Tyr Cys Asn Glu Thr Cys Ser Pro Gly Phe Tyr Gly Glu Ala Cys
     395                 400                 405

 cag cag atc tgc agc tgc caa aat ggg gca gac tgt gac agt gtg act     1478
 Gln Gln Ile Cys Ser Cys Gln Asn Gly Ala Asp Cys Asp Ser Val Thr
 410                 415                 420                 425

 gga aag tgc acc tgt gcc cca gga ttc aaa gga att gac tgc tct acc     1526
 Gly Lys Cys Thr Cys Ala Pro Gly Phe Lys Gly Ile Asp Cys Ser Thr
                 430                 435                 440

 cca tgc cct ctg gga acc tat ggg ata aac tgt tcc tct cgc tgt ggc     1574
 Pro Cys Pro Leu Gly Thr Tyr Gly Ile Asn Cys Ser Ser Arg Cys Gly
             445                 450                 455

 tgt aaa aat gat gca gtc tgc tct cct gtg gac ggg tct tgt act tgc     1622
 Cys Lys Asn Asp Ala Val Cys Ser Pro Val Asp Gly Ser Cys Thr Cys
         460                 465                 470

 aag gca ggc tgg cac ggg gtg gac tgc tcc atc aga tgt ccc agt ggc     1670
 Lys Ala Gly Trp His Gly Val Asp Cys Ser Ile Arg Cys Pro Ser Gly
     475                 480                 485

 aca tgg ggc ttt ggc tgt aac tta aca tgc cag tgc ctc aac ggg gga     1718
 Thr Trp Gly Phe Gly Cys Asn Leu Thr Cys Gln Cys Leu Asn Gly Gly
 490                 495                 500                 505

 gcc tgc aac acc ctg gac ggg acc tgc acg tgt gca cct gga tgg cgc     1766
 Ala Cys Asn Thr Leu Asp Gly Thr Cys Thr Cys Ala Pro Gly Trp Arg
                 510                 515                 520

 ggg gag aaa tgc gaa ctt ccc tgc cag gat ggc acg tac ggg ctg aac     1814
 Gly Glu Lys Cys Glu Leu Pro Cys Gln Asp Gly Thr Tyr Gly Leu Asn
             525                 530                 535

 tgt gct gag cgc tgc gac tgc agc cac gca gat ggc tgc cac cct acc     1862
 Cys Ala Glu Arg Cys Asp Cys Ser His Ala Asp Gly Cys His Pro Thr
         540                 545                 550

 acg ggc cat tgc cgc tgc ctc ccc gga tgg tca ggt gtc cac tgt gac     1910
 Thr Gly His Cys Arg Cys Leu Pro Gly Trp Ser Gly Val His Cys Asp
     555                 560                 565

 agc gtg tgt gct gag gga cgc tgg ggc ccc aac tgc tcc ctg ccc tgc     1958
 Ser Val Cys Ala Glu Gly Arg Trp Gly Pro Asn Cys Ser Leu Pro Cys
 570                 575                 580                 585

 tac tgt aaa aat ggg gct tca tgc tcc cct gat gat ggc atc tgc gag     2006
 Tyr Cys Lys Asn Gly Ala Ser Cys Ser Pro Asp Asp Gly Ile Cys Glu
                 590                 595                 600

 tgt gca cca ggc ttc cga ggc acc act tgt cag agg atc tgc tcc cct     2054
 Cys Ala Pro Gly Phe Arg Gly Thr Thr Cys Gln Arg Ile Cys Ser Pro
             605                 610                 615

 ggt ttt tat ggg cat cgc tgc agc cag aca tgc cca cag tgc gtt cac     2102
 Gly Phe Tyr Gly His Arg Cys Ser Gln Thr Cys Pro Gln Cys Val His
         620                 625                 630

 agc agc ggg ccc tgc cac cac atc acc ggc ctg tgt gac tgc ttg cct     2150
 Ser Ser Gly Pro Cys His His Ile Thr Gly Leu Cys Asp Cys Leu Pro
     635                 640                 645

 ggc ttc aca ggc gcc ctc tgc aat gaa gtg tgt ccc agt ggc aga ttt     2198
 Gly Phe Thr Gly Ala Leu Cys Asn Glu Val Cys Pro Ser Gly Arg Phe
 650                 655                 660                 665

 ggg aaa aac tgt gca gga att tgt acc tgc acc aac aac gga acc tgt     2246
 Gly Lys Asn Cys Ala Gly Ile Cys Thr Cys Thr Asn Asn Gly Thr Cys
                 670                 675                 680

 aac ccc att gac aga tct tgt cag tgt tac ccc ggt tgg att ggc agt     2294
 Asn Pro Ile Asp Arg Ser Cys Gln Cys Tyr Pro Gly Trp Ile Gly Ser
             685                 690                 695

 gac tgc tct caa cca tgt cca cct gcc cac tgg ggc cca aac tgc atc     2342
 Asp Cys Ser Gln Pro Cys Pro Pro Ala His Trp Gly Pro Asn Cys Ile
         700                 705                 710

 cac acg tgc aac tgc cat aat gga gct ttc tgc agc gcc tac gat ggg     2390
 His Thr Cys Asn Cys His Asn Gly Ala Phe Cys Ser Ala Tyr Asp Gly
     715                 720                 725

 gaa tgt aaa tgc act cct ggc tgg aca ggg ctc tac tgc act cag aga     2438
 Glu Cys Lys Cys Thr Pro Gly Trp Thr Gly Leu Tyr Cys Thr Gln Arg
 730                 735                 740                 745

 tgt cct cta ggg ttt tat gga aaa gat tgt gca ctg ata tgc caa tgt     2486
 Cys Pro Leu Gly Phe Tyr Gly Lys Asp Cys Ala Leu Ile Cys Gln Cys
                 750                 755                 760

 caa aac gga gct gac tgc gac cac att tct ggg cag tgt act tgc cgc     2534
 Gln Asn Gly Ala Asp Cys Asp His Ile Ser Gly Gln Cys Thr Cys Arg
             765                 770                 775

 act gga ttc atg gga cgg cac tgt gag cag aag tgc cct tca gga aca     2582
 Thr Gly Phe Met Gly Arg His Cys Glu Gln Lys Cys Pro Ser Gly Thr
         780                 785                 790

 tat ggc tat ggc tgt cgc cag ata tgt gat tgt ctg aac aac tcc acc     2630
 Tyr Gly Tyr Gly Cys Arg Gln Ile Cys Asp Cys Leu Asn Asn Ser Thr
     795                 800                 805

 tgc gac cac atc act ggg acc tgt tac tgc agc ccc gga tgg aag gga     2678
 Cys Asp His Ile Thr Gly Thr Cys Tyr Cys Ser Pro Gly Trp Lys Gly
 810                 815                 820                 825

 gcg aga tgt gat caa gct ggt gtt atc ata gtt gga aat ctg aac agc     2726
 Ala Arg Cys Asp Gln Ala Gly Val Ile Ile Val Gly Asn Leu Asn Ser
                 830                 835                 840

 tta agc cga acc agt act gct ctc cct gct gat tcc tac cag atc ggg     2774
 Leu Ser Arg Thr Ser Thr Ala Leu Pro Ala Asp Ser Tyr Gln Ile Gly
             845                 850                 855

 gcc att gca ggc atc atc att ctt gtc cta gtt gtt ctc ttc cta ctg     2822
 Ala Ile Ala Gly Ile Ile Ile Leu Val Leu Val Val Leu Phe Leu Leu
         860                 865                 870

 gca ttg ttc att att tat aga cac aag cag aag gga aag gaa tca agc     2870
 Ala Leu Phe Ile Ile Tyr Arg His Lys Gln Lys Gly Lys Glu Ser Ser
     875                 880                 885

 atg cca gca gtt acc tac acc cct gct atg agg gtc gtc aat gca gat     2918
 Met Pro Ala Val Thr Tyr Thr Pro Ala Met Arg Val Val Asn Ala Asp
 890                 895                 900                 905

 tat acc att tca gga acc ctt cct cac agc aat ggt gga aac gct aat     2966
 Tyr Thr Ile Ser Gly Thr Leu Pro His Ser Asn Gly Gly Asn Ala Asn
                 910                 915                 920

 agc cac tac ttc acc aat ccc agt tac cac acg ctc acc cag tgt gcc     3014
 Ser His Tyr Phe Thr Asn Pro Ser Tyr His Thr Leu Thr Gln Cys Ala
             925                 930                 935

 aca tcc cct cac gtc aac aac agg gac agg atg act gtc acg aag tca     3062
 Thr Ser Pro His Val Asn Asn Arg Asp Arg Met Thr Val Thr Lys Ser
         940                 945                 950

 aaa aac aat caa ctg ttt gtg aat ctt aaa aat gtg aac cct ggg aag     3110
 Lys Asn Asn Gln Leu Phe Val Asn Leu Lys Asn Val Asn Pro Gly Lys
     955                 960                 965

 aga ggc cct gtg ggg gac tgc act ggg aca ttg ccg gct gac tgg aaa     3158
 Arg Gly Pro Val Gly Asp Cys Thr Gly Thr Leu Pro Ala Asp Trp Lys
 970                 975                 980                 985

 cat ggc ggc tac ctc aac gag ctc ggt gct ttt gga ctt gac aga agc     3206
 His Gly Gly Tyr Leu Asn Glu Leu Gly Ala Phe Gly Leu Asp Arg Ser
                 990                 995                1000

 tat atg gga aaa tcc tta aaa gac ctg gga aag aat tct gaa tat aat     3254
 Tyr Met Gly Lys Ser Leu Lys Asp Leu Gly Lys Asn Ser Glu Tyr Asn
            1005                1010                1015

 tca agt aac tgc tcc cta agc agt tct gag aac cca tat gcc act att     3302
 Ser Ser Asn Cys Ser Leu Ser Ser Ser Glu Asn Pro Tyr Ala Thr Ile
        1020                1025                1030

 aaa gac cca cct gta ctt atc ccg aaa agc tca gag tgt ggt tat gtg     3350
 Lys Asp Pro Pro Val Leu Ile Pro Lys Ser Ser Glu Cys Gly Tyr Val
    1035                1040                1045

 gag atg aaa tcg ccg gca cga aga gat tcc cca tat gca gag atc aat     3398
 Glu Met Lys Ser Pro Ala Arg Arg Asp Ser Pro Tyr Ala Glu Ile Asn
1050                1055                1060                1065

 aac tca act tca gcc aac agg aat gtc tat gaa gtt gaa cct aca gtg     3446
 Asn Ser Thr Ser Ala Asn Arg Asn Val Tyr Glu Val Glu Pro Thr Val
                1070                1075                1080

 agt gtt gtc caa gga gta ttc agc aat aat ggg cgt ctc tcc cag gat     3494
 Ser Val Val Gln Gly Val Phe Ser Asn Asn Gly Arg Leu Ser Gln Asp
            1085                1090                1095

 cca tat gac ctc cca aag aac agt cac atc cct tgt cat tat gac ctg     3542
 Pro Tyr Asp Leu Pro Lys Asn Ser His Ile Pro Cys His Tyr Asp Leu
        1100                1105                1110

 ctg cca gtc cga gac agt tca tcc tcc cct aag caa gag gac agt gga     3590
 Leu Pro Val Arg Asp Ser Ser Ser Ser Pro Lys Gln Glu Asp Ser Gly
    1115                1120                1125

 ggt agc agc agc aac agc agc agc agc agt gaa tga cacc aaaggaccgc     3640
 Gly Ser Ser Ser Asn Ser Ser Ser Ser Ser Glu 
1130                1135                1140

 ttggtagcca ctggaaccct ttccagaact gctgtttggt tcttctccat cctcaatttt   3700

 gccactttca tgtgaatgtt agtcaattcg gtgggcaatt tttggacatg aaccagaaag   3760

 ctgaaagctg aggctgacac ggactgtagg tgctttttgt tcaggtggat tcgaaggagt   3820

 tagagatgtg atttgccatt gctgttagtt ttagaactat acccgtgaag catgacttat   3880

 tgtaagatgt tggctgaaag catgaacttg cagaactccc tcggagacgc aggttgcagt   3940

 ggacattggg attgttgctt gaaaaattaa aatttgaata ttttctctct catttgcatc   4000

 atacagctct acctaggatt gtacagttta ccataaaatt tacttcatga aagtgggaat   4060

 cactgaacat gtagaagaca aggaacatat tgttaactcc tgattcttaa ctttattcaa   4120

 ctggactcag aattgtaggg ataatatgaa tgcaggagga aacattctgt caggcggtat   4180

 gactggacag actttgaata tactctaaaa gtggacagaa aatttacgaa aatcttagat   4240

 tttgtttaga atgagaaaat atacaattag aattatttta gaaatagtag gaagtattgc   4300

 agaagtcaat acacaaatgt gccaggcaga ggtggttttc tctgtttgac tctcaaccaa   4360

 cttcagatct atgacattat tctgatcact ggctccatca tacatattca ccacttgaga   4420

 ttcataacat atcaatagtt atttcataaa tatagaaatg aaataatttt atttttgaca   4480

 gactggatgg aatgagtgtg taatgattga taaaggttgt aaattttaaa tgcaagatga   4540

 cgcttacgtt ctgtaaacca ttagtaatac atgctgtaat atagaattag tggaacattt   4600

 tgattaatct ttccctagaa gtgactgaaa tatttttgtg catatttgag aaagggaact   4660

 ttccttttat taattgtcaa tttagagaaa ctatgcttaa gctggtcttt tgcattgcta   4720

 atgtgacatg tacccaactt ttcattaatt tgtatttcca tttttaaatt gcatattcta   4780

 tgttttgtag tgtttggatt gttaatgaaa aaatattata tgttcgttat tccttgtatt   4840

 attgccactt atcttttgct tgataaaaat gcgttgttct tttttctttt ggagggacaa   4900

 gatgaaaata tataatttga attgattaaa attggtcgtt actaaaatag tatagtaacc   4960

 acaagtgatt ggcttataaa tgaagtagaa atgcttttta atattccaaa atagagttcc   5020

 ttttgatctg ttggtgctga gccttggtta aaccagggag aaggggagca gaaaggaaac   5080

 gttgttactg atgagtacca cagactcatc ttaaaaaaaa ctctcattat ggtgatcata   5140

 gaattgacca tccaaactgg gacactcttg agagtaaatg gagggcatta ttaataatta   5200

 tcttgtaatg aacttaaatc tggactgttc caggcaaacc agacttatct tgcaatatga   5260

 gaatgctgac acaatgcagg aaagccagtt tcccttttgt tgatctactt gaccaagcaa   5320

 aggggctgaa aaactgaata aggaaacaac tttataagag aaacagtggt cttcaatctt   5380

 ttaaagacat gaaatcctat atggcattct gtctcagtga gtcagttaac aaatacgtat   5440

 gtgcaaccct tctgctagta gtgcacataa gtgattatcc ctgccaggta tcgagttgga   5500

 atatccagtt atttcatgtc acacatcggc acgtatgatg gtggtttggt cagatggata   5560

 atacagcaga cacacttaga acactcactg cactggtggc tgttcatttt gaggaactcc   5620

 aaagtcaatt caaggaaata aggaatgacc tggaacaggc cttagaaaca attgatttat   5680

 tccaatagtt aaccactggc tggctcccaa ctctaggtga taggcatcta attgagacat   5740

 gtgtgagtca atagccatcg gggtcctttt tggtgagaag aaataagaca ttttctccct   5800

 tttaaagatc atctcttcag agctgcatgg taaatttgaa tttccccatt gttctctaga   5860

 gataggtcaa aaaaacaact gtttcttttc ttattccact attaataaat tgaaagcttg   5920

 ctgtacaaag gcaacagcaa cttaaaaaag aaaatctgga caatagatgt ggactccaag   5980

 gggccactgc catcccttcc tgtgtgctct ttttgacaag taaatcactc cagttagctg   6040

 atgtcctgaa atgacatttg tacctgaggc aattcttatt agagcttact caggactttt   6100

 caaacatcag gacacacata gcaatttgga tgttgtaaaa ctacgtgtta catttggaga   6160

 ggtcttgttg agaaggcaaa attttctaaa tattttgata tcaatttggg taaagaaagg   6220

 aatacttttg ttagaatgag aattaaagag aaaacaaaag aatcttggca aaattttccc   6280

 tctgaaatta caaactttag gaacttttcc agatgtatcg aatttaattt gacattgatg   6340

 tcactcttca taccaagtga atctattctc atgaactttg aacccatgtt aattttggac   6400

 cctataacta atttcctttc tgtatcccat ggtggtcaaa gcagtaaagg agtttagaga   6460

 tacttagcaa atgccattca tatagtattg ttagccaaac tattattcct tccttagaag   6520

 ttgatgtatc agaaaattta taagttattt gtatttatat ataagtacat cagaacttgc   6580

 ccacatgata actcatgttt gctttaataa ggaaaatatg ttatttgagg ttaattatat   6640

 gatagtgagg aacattttac aattatttac agtgtttgac attaattgct gtcctatgat   6700

 acagtagtaa tgttaacaga gagtttaata tgtttagcat tatctttatg gaatttatat   6760

 tcaccaattt caggaaaacc aaccatagaa ctttataata ggacagttat aacctgactg   6820

 aaccaaatcc atcagcataa tgactgtgtg ttctgagaaa tgcaaacaac tttatgaaag   6880

 tgtggtcatc ttgaccccca aagagccaca gtagctgtca attattgaga tttttaaatg   6940

 gtaaatattg caaaagttaa acaagggtac cacaatatca tttataattg atgtcaatat   7000

 tagtagtcca ctttatgctt aaaataaaat cataaaaaat caagttttaa ggttatattt   7060

 tttaaaataa tgaattttct atctctaggc aacatgtctt tattattcaa gctgaatgtt   7120

 taagagagat tttggtctta aaggcttcac atcatgaaag tgtacatgca tatgcaagtg   7180

 tgaattacgt ggtatggatg gttgcttgtt tattaactaa agatgtacag caaactgccc   7240

 gtttagagtc ctgttaatat tgatgtccta acactgggtc tgcttatgct agttcagtat   7300

 ttggtctagg cttcattttg atatgactga attgcaatct atatttttaa aaagaaaaat   7360

 caaaatacat tagggtttac ttggttgtgg caaacaaaca aaaaatgctt tcagtgttga   7420

 aatatctcta ttttccaaag atgataaact ttcatcgttc ttagcctaca ttgtcattta   7480

 tatcaccaaa tgagtttata gattaatgca ataaactttc taat                    7524




      <210> 564
      <211> 3466
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (81)..(2609)

      <400> 564
 aatttgatca aggctgtttg tgtctggcta atgttgacaa tagtggaaat ggacaagata     60

 aaataattgt gggtagcttt    atg gga tac cta agg atc ttt agc ccc cat     110
                          Met Gly Tyr Leu Arg Ile Phe Ser Pro His
                            1               5                  10

 cct gca aaa aca gga gat gga gct caa gcc gaa gat ttg ctt cta gaa      158
 Pro Ala Lys Thr Gly Asp Gly Ala Gln Ala Glu Asp Leu Leu Leu Glu
                  15                  20                  25

 gtg gat cta cga gat cca gta ctt caa gtg gaa gta gga aag ttt gtt      206
 Val Asp Leu Arg Asp Pro Val Leu Gln Val Glu Val Gly Lys Phe Val
              30                  35                  40

 tca ggt acc gaa atg cta cat ttg gct gtg tta cat tct aga aaa ctt      254
 Ser Gly Thr Glu Met Leu His Leu Ala Val Leu His Ser Arg Lys Leu
          45                  50                  55

 tgt gtc tac tct gtc tca gga acc ttg ggt aat gtg gaa cat ggg aac      302
 Cys Val Tyr Ser Val Ser Gly Thr Leu Gly Asn Val Glu His Gly Asn
      60                  65                  70

 caa tgt cag atg aaa ttg atg tat gaa cat aat ctt cag aga aca gcc      350
 Gln Cys Gln Met Lys Leu Met Tyr Glu His Asn Leu Gln Arg Thr Ala
  75                  80                  85                  90

 tgc aat atg acc tat gga tca ttt ggt ggt gta aaa ggt cga gat tta      398
 Cys Asn Met Thr Tyr Gly Ser Phe Gly Gly Val Lys Gly Arg Asp Leu
                  95                 100                 105

 att tgc atc cag tct atg gat ggg atg ctg atg gta ttt gag cag gag      446
 Ile Cys Ile Gln Ser Met Asp Gly Met Leu Met Val Phe Glu Gln Glu
             110                 115                 120

 agc tat gct ttt gga aga ttt ctc cct ggc ttt ctt ctg cct ggt cct      494
 Ser Tyr Ala Phe Gly Arg Phe Leu Pro Gly Phe Leu Leu Pro Gly Pro
         125                 130                 135

 ctt gcc tac agt tcc cgt aca gat tcc ttc ctt act gtc tct tcc tgc      542
 Leu Ala Tyr Ser Ser Arg Thr Asp Ser Phe Leu Thr Val Ser Ser Cys
     140                 145                 150

 caa caa gtg gaa agt tat aag tac cag gta ctt gct ttt gca aca gat      590
 Gln Gln Val Glu Ser Tyr Lys Tyr Gln Val Leu Ala Phe Ala Thr Asp
 155                 160                 165                 170

 gca gat aaa agg cag gag act gaa cag caa aaa ctt ggt tct gga aaa      638
 Ala Asp Lys Arg Gln Glu Thr Glu Gln Gln Lys Leu Gly Ser Gly Lys
                 175                 180                 185

 aga cta gtt gtg gat tgg act cta aat att gga gag caa gcc ctt gac      686
 Arg Leu Val Val Asp Trp Thr Leu Asn Ile Gly Glu Gln Ala Leu Asp
             190                 195                 200

 ata tgt att gtc tct ttc aat cag tcg gca tcc tct gtt ttt gtt ctt      734
 Ile Cys Ile Val Ser Phe Asn Gln Ser Ala Ser Ser Val Phe Val Leu
         205                 210                 215

 ggt gag aga aac ttt ttt tgc ctt aag gat aat gga caa att cga ttc      782
 Gly Glu Arg Asn Phe Phe Cys Leu Lys Asp Asn Gly Gln Ile Arg Phe
     220                 225                 230

 atg aag aag ctt gat tgg agc cca agt tgt ttt ctg cca tat tgc tca      830
 Met Lys Lys Leu Asp Trp Ser Pro Ser Cys Phe Leu Pro Tyr Cys Ser
 235                 240                 245                 250

 gtt tct gaa gga aca ata aat act ttg att gga aat cat aat aac atg      878
 Val Ser Glu Gly Thr Ile Asn Thr Leu Ile Gly Asn His Asn Asn Met
                 255                 260                 265

 ctg cat att tat caa gat gtg aca ctg aag tgg gcc acc caa ctt ccc      926
 Leu His Ile Tyr Gln Asp Val Thr Leu Lys Trp Ala Thr Gln Leu Pro
             270                 275                 280

 cac att cct gta gca gta aga gtg ggc tgt ttg cat gat tta aag gga      974
 His Ile Pro Val Ala Val Arg Val Gly Cys Leu His Asp Leu Lys Gly
         285                 290                 295

 gtg ata gtc act ctg agt gat gat ggt cac ttg cag tgt tca tac ctg     1022
 Val Ile Val Thr Leu Ser Asp Asp Gly His Leu Gln Cys Ser Tyr Leu
     300                 305                 310

 ggg aca gat cct tct ctg ttc caa gct cca aac gtt caa tct cga gaa     1070
 Gly Thr Asp Pro Ser Leu Phe Gln Ala Pro Asn Val Gln Ser Arg Glu
 315                 320                 325                 330

 cta aac tat gat gaa ctt gat gta gaa atg aaa gaa ctt cag aaa atc     1118
 Leu Asn Tyr Asp Glu Leu Asp Val Glu Met Lys Glu Leu Gln Lys Ile
                 335                 340                 345

 atc aaa gat gtt aac aaa tca caa ggt gtt tgg ccc atg act gag aga     1166
 Ile Lys Asp Val Asn Lys Ser Gln Gly Val Trp Pro Met Thr Glu Arg
             350                 355                 360

 gaa gat gac ttg aac gtt tct gtc gtg gtt tct cct aac ttt gat tca     1214
 Glu Asp Asp Leu Asn Val Ser Val Val Val Ser Pro Asn Phe Asp Ser
         365                 370                 375

 gtt tct caa gcg acc gat gtt gag gtg gga act gac ctt gtc cct tct     1262
 Val Ser Gln Ala Thr Asp Val Glu Val Gly Thr Asp Leu Val Pro Ser
     380                 385                 390

 gtc acg gtg aag gtc aca ctg cag aac aga gtg ata ttg caa aaa gcc     1310
 Val Thr Val Lys Val Thr Leu Gln Asn Arg Val Ile Leu Gln Lys Ala
 395                 400                 405                 410

 aaa tta tca gtc tac gtg caa cca cca tta gaa ttg act tgt gat cag     1358
 Lys Leu Ser Val Tyr Val Gln Pro Pro Leu Glu Leu Thr Cys Asp Gln
                 415                 420                 425

 ttc acc ttt gaa ttt atg aca cca gat ttg act aga aca gta agc ttt     1406
 Phe Thr Phe Glu Phe Met Thr Pro Asp Leu Thr Arg Thr Val Ser Phe
             430                 435                 440

 tct gtt tat ctg aaa aga agt tat aca cca tca gaa ttg gaa gga aat     1454
 Ser Val Tyr Leu Lys Arg Ser Tyr Thr Pro Ser Glu Leu Glu Gly Asn
         445                 450                 455

 gct gtt gtt tct tat tcc aga cca aca gat cga aat cct gat ggc att     1502
 Ala Val Val Ser Tyr Ser Arg Pro Thr Asp Arg Asn Pro Asp Gly Ile
     460                 465                 470

 ccg cga gtt atc caa tgt aaa ttt aga ctt ccc cta aag tta att tgc     1550
 Pro Arg Val Ile Gln Cys Lys Phe Arg Leu Pro Leu Lys Leu Ile Cys
 475                 480                 485                 490

 cta cca ggt cag cct tca aaa act gca agc cac aaa att act att gat     1598
 Leu Pro Gly Gln Pro Ser Lys Thr Ala Ser His Lys Ile Thr Ile Asp
                 495                 500                 505

 acc aac aaa tct cca gtc agt ctt ctt agt ctc ttc cca ggt ttt gcc     1646
 Thr Asn Lys Ser Pro Val Ser Leu Leu Ser Leu Phe Pro Gly Phe Ala
             510                 515                 520

 agt cag tca gat gat gat cag gtg aat gta atg ggt ttt cac ttc tta     1694
 Ser Gln Ser Asp Asp Asp Gln Val Asn Val Met Gly Phe His Phe Leu
         525                 530                 535

 gga ggt gct cga att act gtt ctt gct tcc aaa act tct caa cga tat     1742
 Gly Gly Ala Arg Ile Thr Val Leu Ala Ser Lys Thr Ser Gln Arg Tyr
     540                 545                 550

 cgc att cag agt gaa caa ttt gaa gat ctt tgg ctc ata acc aat gag     1790
 Arg Ile Gln Ser Glu Gln Phe Glu Asp Leu Trp Leu Ile Thr Asn Glu
 555                 560                 565                 570

 ctt att ctt cgc ctt caa gaa tat ttt gaa aaa cag gga gtc aaa gat     1838
 Leu Ile Leu Arg Leu Gln Glu Tyr Phe Glu Lys Gln Gly Val Lys Asp
                 575                 580                 585

 ttt gca tgt tct ttt tcg gga tct ata ccc ctt caa gaa tat ttt gag     1886
 Phe Ala Cys Ser Phe Ser Gly Ser Ile Pro Leu Gln Glu Tyr Phe Glu
             590                 595                 600

 ttg att gat cat cat ttt gag cta cgg ata aat ggt gaa aaa tta gaa     1934
 Leu Ile Asp His His Phe Glu Leu Arg Ile Asn Gly Glu Lys Leu Glu
         605                 610                 615

 gaa ctc tta tct gag aga gct gta caa ttt cgg gcc att caa cgc cgg     1982
 Glu Leu Leu Ser Glu Arg Ala Val Gln Phe Arg Ala Ile Gln Arg Arg
     620                 625                 630

 cta cta gca aga ttc aaa gat aaa act cct gcc cct ctt caa cac ctg     2030
 Leu Leu Ala Arg Phe Lys Asp Lys Thr Pro Ala Pro Leu Gln His Leu
 635                 640                 645                 650

 gac acc ttg tta gat gga acc tac aag cag gta att gct cta gca gat     2078
 Asp Thr Leu Leu Asp Gly Thr Tyr Lys Gln Val Ile Ala Leu Ala Asp
                 655                 660                 665

 gca gtg gag gaa aac caa ggc aat ctg ttc cag tca ttc acc agg ctg     2126
 Ala Val Glu Glu Asn Gln Gly Asn Leu Phe Gln Ser Phe Thr Arg Leu
             670                 675                 680

 aag agt gcc acc cat ttg gtg att ctg ctg atc gcg ctg tgg cag aag     2174
 Lys Ser Ala Thr His Leu Val Ile Leu Leu Ile Ala Leu Trp Gln Lys
         685                 690                 695

 ctt agt gct gac cag gtt gct att ctg gaa gcg gca ttt ctg ccc gta     2222
 Leu Ser Ala Asp Gln Val Ala Ile Leu Glu Ala Ala Phe Leu Pro Val
     700                 705                 710

 caa gaa gac act caa gaa ttg ggc tgg gaa gaa acg gtg gat gcc gcc     2270
 Gln Glu Asp Thr Gln Glu Leu Gly Trp Glu Glu Thr Val Asp Ala Ala
 715                 720                 725                 730

 att tcc cac ctg ttg aag act tgc ctg tcg aag agt tct aag gag cag     2318
 Ile Ser His Leu Leu Lys Thr Cys Leu Ser Lys Ser Ser Lys Glu Gln
                 735                 740                 745

 gct ttg aac ctc aac agc cag ctg aac ata ccc aaa gac aca agc caa     2366
 Ala Leu Asn Leu Asn Ser Gln Leu Asn Ile Pro Lys Asp Thr Ser Gln
             750                 755                 760

 ctg aag aaa cat atc acc ttg ctc tgc gat aga tta tcc aaa ggt ggc     2414
 Leu Lys Lys His Ile Thr Leu Leu Cys Asp Arg Leu Ser Lys Gly Gly
         765                 770                 775

 cgt ctc tgc cta agt acc gat gca gca gcc cca cag acc atg gtc atg     2462
 Arg Leu Cys Leu Ser Thr Asp Ala Ala Ala Pro Gln Thr Met Val Met
     780                 785                 790

 cca ggt ggt tgt act aca atc cca gag tca gac cta gaa gaa aga tca     2510
 Pro Gly Gly Cys Thr Thr Ile Pro Glu Ser Asp Leu Glu Glu Arg Ser
 795                 800                 805                 810

 gta gaa caa gac tct aca gaa ctg ttt acc aac cac aga cat ctc act     2558
 Val Glu Gln Asp Ser Thr Glu Leu Phe Thr Asn His Arg His Leu Thr
                 815                 820                 825

 gca gag aca ccc agg cct gaa gtt tca ccc ctc caa gga gtc tcg gaa     2606
 Ala Glu Thr Pro Arg Pro Glu Val Ser Pro Leu Gln Gly Val Ser Glu
             830                 835                 840

 taa ttca agtagagttg tttggttgag aggaacatcc ccatctcaag gccgaacctg     2663
 


 tgtgaacctc atgccaagca cagatatagg gctggcgcag gtgcttccca aagcttacct   2723

 tcctggagat gacatgcata gaaagagggg ttgggacttt ttacttcact aggagaactt   2783

 gtaacaccat ggggaagtca gctgaaactt gtcttgtttt gccaggaaag gaagtagttg   2843

 cctttggtca tccatctgct aatagtcaca gaatacagtg aaatgacata gttttgggtt   2903

 agattttata atgcaaagat tcagatccaa aataatttca taccccattt tttcacagaa   2963

 ttcttatata gtaaatgtat caagtttaat aaagcatctc attgtcaaat aatatcttgg   3023

 attttattta taattagagg gatttatgag tgattgctct acattatttc ttcaaaggaa   3083

 aggaaaggaa ttgaagactt tgctactctc tggtaagact tgaatgtgat tattttataa   3143

 ataaaagaac cactatgaaa ctttcatgtg atttgttcta ttaagctaaa cgtggaagaa   3203

 gggaagtttt ctagtattgt atgaaaatgt ttaaatattt tcaaggaagc tagtacatta   3263

 acatcccctt ttcattaccc cattgggtgg caccttttaa aaatccaggt tattaaagga   3323

 ttcacacttt attacagtta aaatttaagg tttttatgtg taagaagtga aagaaacttt   3383

 gctaatttca agttcgaatt acagttgtga gattgattta tttaaataaa aatatgcctt   3443

 tgccagttaa aaaaaaaaaa aaa                                           3466




      <210> 565
      <211> 1888
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (343)..(1095)

      <400> 565
 agcggagtat acagggagga cacaaacatg agaagattaa ggtagagagt gaaatatggt     60

 caggacaaat gtgaatttag agcctgagtg atggtttagt ggatttatgt cctcacttgt    120

 cactaatgaa aaggacctta caggttatat aattaaagct ctgttgacat tggctcttga    180

 aggcaaactt cataatgagg ggaagagtca agttttgtgt aacctgaagc atatacagtg    240

 tccattgcca gcacttgagt aaagataaag agtaggagaa tcaaagctgt tgtataatta    300

 gttctcttct catccacacc cataaaccag ttcaagaaag gg   atg cag gta caa     354
                                                  Met Gln Val Gln
                                                    1

 ctt ggc caa gta gaa atc aaa tgc ccc atc aca gag tgt ttt gaa ttc      402
 Leu Gly Gln Val Glu Ile Lys Cys Pro Ile Thr Glu Cys Phe Glu Phe
   5                  10                  15                  20

 ttg gaa gaa aca act gtt gtc tat aac tta acg cat gaa gac tcc atc      450
 Leu Glu Glu Thr Thr Val Val Tyr Asn Leu Thr His Glu Asp Ser Ile
                  25                  30                  35

 aag tat aag tac ttc ttg gaa ctt ggc cgt att gat tcc agc acc aag      498
 Lys Tyr Lys Tyr Phe Leu Glu Leu Gly Arg Ile Asp Ser Ser Thr Lys
              40                  45                  50

 cca tgt cct cag tgc aag cac ttt aca acc ttc aag aaa aaa gga cat      546
 Pro Cys Pro Gln Cys Lys His Phe Thr Thr Phe Lys Lys Lys Gly His
          55                  60                  65

 att ccc acc cct tcc aga tca gaa agc aaa tac aaa atc cag tgc cct      594
 Ile Pro Thr Pro Ser Arg Ser Glu Ser Lys Tyr Lys Ile Gln Cys Pro
      70                  75                  80

 acc tgc caa ttc gtc tgg tgt ttt aag tgc cac tct cct tgg cat gaa      642
 Thr Cys Gln Phe Val Trp Cys Phe Lys Cys His Ser Pro Trp His Glu
  85                  90                  95                 100

 ggt gtt aac tgc aag gag tac aaa aaa gga gac aaa ttg ttg cgt cac      690
 Gly Val Asn Cys Lys Glu Tyr Lys Lys Gly Asp Lys Leu Leu Arg His
                 105                 110                 115

 tgg gcc agc gaa att gag cat ggg cag agg aat gcc cag aag tgt cca      738
 Trp Ala Ser Glu Ile Glu His Gly Gln Arg Asn Ala Gln Lys Cys Pro
             120                 125                 130

 aag tgc aag atc cac atc cag cga act gaa gga tgt gac cat atg acc      786
 Lys Cys Lys Ile His Ile Gln Arg Thr Glu Gly Cys Asp His Met Thr
         135                 140                 145

 tgc tca caa tgt aac act aat ttt tgt tac cga tgt ggt gag aga tac      834
 Cys Ser Gln Cys Asn Thr Asn Phe Cys Tyr Arg Cys Gly Glu Arg Tyr
     150                 155                 160

 cgc cag ctc cga ttt ttt gga gac cac aca tca aac ctc agt ata ttt      882
 Arg Gln Leu Arg Phe Phe Gly Asp His Thr Ser Asn Leu Ser Ile Phe
 165                 170                 175                 180

 gga tgc aaa tat cgc tac ctc cca gag aga cct cat tta agg aga tta      930
 Gly Cys Lys Tyr Arg Tyr Leu Pro Glu Arg Pro His Leu Arg Arg Leu
                 185                 190                 195

 gtg cga ggg tca gtc tgt gct gga aaa tta ttc att gca cct cta att      978
 Val Arg Gly Ser Val Cys Ala Gly Lys Leu Phe Ile Ala Pro Leu Ile
             200                 205                 210

 atg gtt ttg gga ttg gca cta ggg gcc ata gcg gtt gta atc ggt tta     1026
 Met Val Leu Gly Leu Ala Leu Gly Ala Ile Ala Val Val Ile Gly Leu
         215                 220                 225

 ttt gta ttt cct atc tat tgc ctt tgt aaa aaa cag aga aaa cga tca     1074
 Phe Val Phe Pro Ile Tyr Cys Leu Cys Lys Lys Gln Arg Lys Arg Ser
     230                 235                 240

 cgg aca ggt atg cac tgg taa ca tgcagatgat ttcatccagc taagctggtt     1127
 Arg Thr Gly Met His Trp 
 245                 250

 ggagtaggag cgataccaaa gggtacaccc atctgtgagt cacatcttga aaaacactga   1187

 gaggaacctt ctaccatctc atctcccagt gattcttccg tgggccacaa tggcctctag   1247

 ctatggtgca ctccccaaca tgggtatcct gttccttttc cctaaaacaa aatttgctgc   1307

 tgctttttaa aaaaattggt ccctttcata aactataaac atctatatca taactctgac   1367

 ctttgtggtt cttggaagaa gatattttaa gaaccagtta tcctaagaat tctgagcacg   1427

 cctcttctga gaattgcttg gactgtcttt gaactctgca cctccttcca ggccatcttg   1487

 tgagacttgg tgttaatagc tgaagtccta tctgtaccaa caagcaaggc cacttttcag   1547

 aagataagag ttcactgaat gcacctatta taatctgtgg ccccagcagt ataattcttt   1607

 tatctttcaa atgttataat tgcaaaaaat ctcaatgtcc aaaagggaat gagtgaaact   1667

 aaattaatga gaagaatatt aagttactga agtgtatatg cgtaggggcg tgaatgtgtg   1727

 tgtatataaa tatgtattaa aactaggccc agtaaccttg tacttaccca gttccatgcc   1787

 gctacactat ttttccacat tttcatagac ctattgaaag atgatggctc ctttgtggac   1847

 ataatttagc aatgtattaa attaaagtca atgtagacaa c                       1888




      <210> 566
      <211> 1197
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (168)..(1007)

      <400> 566
 agcgggtttt gcagcccgcg gcgctttccc ctccgcggtt cctccccgag ccgcccccag     60

 tgcccaagct tccgcggctc cgccgaccag gggccgcgcc gactgggaac tcgccagggg    120

 cgtagtcccc tgcaaggcct gggggccggc gaggccgcag aggcggg  atg ggc ctg     176
                                                      Met Gly Leu
                                                        1

 agc ccg ggc gcc gag ggg gag tac gcg ctc cgc ctc cct agg att ccc      224
 Ser Pro Gly Ala Glu Gly Glu Tyr Ala Leu Arg Leu Pro Arg Ile Pro
       5                  10                  15

 cca ccc ctc ccc aaa ccc gcc tcg cga acc gcc ggt acc ggg ccc aag      272
 Pro Pro Leu Pro Lys Pro Ala Ser Arg Thr Ala Gly Thr Gly Pro Lys
  20                  25                  30                  35

 gac cag ccg cct gcg ctc aga cgt tca gct gtg ccc cac tca ggt cta      320
 Asp Gln Pro Pro Ala Leu Arg Arg Ser Ala Val Pro His Ser Gly Leu
                  40                  45                  50

 aat agc att tcc ccc ctt gaa tta gaa gaa tcc gtg gga ttc gca gcg      368
 Asn Ser Ile Ser Pro Leu Glu Leu Glu Glu Ser Val Gly Phe Ala Ala
              55                  60                  65

 ttg gtc cag ctc cca gcc aag cag cct ccg ccg ggc aca tta gaa cag      416
 Leu Val Gln Leu Pro Ala Lys Gln Pro Pro Pro Gly Thr Leu Glu Gln
          70                  75                  80

 ggc aga agc atc cag caa ggg gag aag gct gta gtt agc ttg gag acc      464
 Gly Arg Ser Ile Gln Gln Gly Glu Lys Ala Val Val Ser Leu Glu Thr
      85                  90                  95

 aca ccc agc cag aaa gca gac tgg agt tca att cca aag cct gag aat      512
 Thr Pro Ser Gln Lys Ala Asp Trp Ser Ser Ile Pro Lys Pro Glu Asn
 100                 105                 110                 115

 gaa ggc aag tta ata aag caa gca gct gag gga aaa cca aga ccc aga      560
 Glu Gly Lys Leu Ile Lys Gln Ala Ala Glu Gly Lys Pro Arg Pro Arg
                 120                 125                 130

 cct gga gac ctg att gag att ttt cga att ggc tat gag cac tgg gcc      608
 Pro Gly Asp Leu Ile Glu Ile Phe Arg Ile Gly Tyr Glu His Trp Ala
             135                 140                 145

 atc tat gta gaa gat gat tgc gtg gtc cat ctg gct ccc cca agt gag      656
 Ile Tyr Val Glu Asp Asp Cys Val Val His Leu Ala Pro Pro Ser Glu
         150                 155                 160

 gag ttt gag gtg ggc agc att act tcc atc ttt agc aat cgg gcc gtg      704
 Glu Phe Glu Val Gly Ser Ile Thr Ser Ile Phe Ser Asn Arg Ala Val
     165                 170                 175

 gtg aaa tac agt cgt ctg gag gat gtg ctg cat ggc tgc tcc tgg aag      752
 Val Lys Tyr Ser Arg Leu Glu Asp Val Leu His Gly Cys Ser Trp Lys
 180                 185                 190                 195

 gtc aat aac aag cta gat ggg acg tac ctg ccc ttg ccg gtg gac aag      800
 Val Asn Asn Lys Leu Asp Gly Thr Tyr Leu Pro Leu Pro Val Asp Lys
                 200                 205                 210

 atc atc cag cgt aca aaa aag atg gtc aac aag atc gtg cag tac agc      848
 Ile Ile Gln Arg Thr Lys Lys Met Val Asn Lys Ile Val Gln Tyr Ser
             215                 220                 225

 ctg att gaa ggg aac tgt gag cac ttt gtc aat ggc ctc aga tat ggc      896
 Leu Ile Glu Gly Asn Cys Glu His Phe Val Asn Gly Leu Arg Tyr Gly
         230                 235                 240

 gta ccc cgg agc cag cag gta gag cac gcc ctg atg gaa gga gcg aag      944
 Val Pro Arg Ser Gln Gln Val Glu His Ala Leu Met Glu Gly Ala Lys
     245                 250                 255

 gct gct gga gca gtt att tca gct gta gtg gat agc ata aag ccc aaa      992
 Ala Ala Gly Ala Val Ile Ser Ala Val Val Asp Ser Ile Lys Pro Lys
 260                 265                 270                 275

 cca ata act gcc tga aggtgatgaa aactccagct agaggaagag ttactgacac     1047
 Pro Ile Thr Ala 


 aagcaaaaag aacatgcttc cttcccttgc cttctctcaa tggctccgat taagaaaatt   1107

 gtgaacttct ggaagaatct acaatgtatc caattaccct tccagaaata catccaatat   1167

 atacgaaaaa aaaaaaaaaa aaaaaaattg                                    1197




      <210> 567
      <211> 1557
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(1265)

      <400> 567
 catctacact agacaccttc ctgcttccct ccttccagag cagacctctt tgtcaccccg     60

 agctccttgt ttcttaagca gtc    atg tct gtg aca aaa agt act gag ggt     110
                              Met Ser Val Thr Lys Ser Thr Glu Gly
                                1               5

 ccc cag gga gcc gtt gcc atc aaa ttg gac ctt atg tcg cct cct gaa      158
 Pro Gln Gly Ala Val Ala Ile Lys Leu Asp Leu Met Ser Pro Pro Glu
  10                  15                  20                  25

 agt gcc aag aag ttg gag aac aag gac tct aca ttc ttg gat gaa agt      206
 Ser Ala Lys Lys Leu Glu Asn Lys Asp Ser Thr Phe Leu Asp Glu Ser
                  30                  35                  40

 cct tca gag tca gca ggc ttg aag aag acc aag ggc ata aca gtg ttc      254
 Pro Ser Glu Ser Ala Gly Leu Lys Lys Thr Lys Gly Ile Thr Val Phe
              45                  50                  55

 cag gcc ttg att cac ctg gtg aaa ggc aac atg ggc aca ggg atc ctg      302
 Gln Ala Leu Ile His Leu Val Lys Gly Asn Met Gly Thr Gly Ile Leu
          60                  65                  70

 gga cta ccc ctc gct gtg aag aac gcg ggc atc ctg atg ggc cca ctc      350
 Gly Leu Pro Leu Ala Val Lys Asn Ala Gly Ile Leu Met Gly Pro Leu
      75                  80                  85

 agt ctg ctg gtg atg ggc ttc att gcc tgc cac tgt atg cac atc ctg      398
 Ser Leu Leu Val Met Gly Phe Ile Ala Cys His Cys Met His Ile Leu
  90                  95                 100                 105

 gtc aag tgt gcc cag cgc ttc tgt aag agg ctt aac aag ccc ttt atg      446
 Val Lys Cys Ala Gln Arg Phe Cys Lys Arg Leu Asn Lys Pro Phe Met
                 110                 115                 120

 gac tat ggg gac acg gtg atg cat gga cta gaa gcc aac ccc aac gcc      494
 Asp Tyr Gly Asp Thr Val Met His Gly Leu Glu Ala Asn Pro Asn Ala
             125                 130                 135

 tgg ctc cag aat cac gct cac tgg gga agg cat atc gtg agc ttc ttc      542
 Trp Leu Gln Asn His Ala His Trp Gly Arg His Ile Val Ser Phe Phe
         140                 145                 150

 ctt att atc acc caa ctt ggc ttc tgc tgt gtg tac att gtg ttt ttg      590
 Leu Ile Ile Thr Gln Leu Gly Phe Cys Cys Val Tyr Ile Val Phe Leu
     155                 160                 165

 gct gat aat tta aaa cag gta gtg gaa gct gtt aat agc aca acc aac      638
 Ala Asp Asn Leu Lys Gln Val Val Glu Ala Val Asn Ser Thr Thr Asn
 170                 175                 180                 185

 aac tgc tat tcc aat gag acg gtg att ctg acc ccc acc atg gac tcg      686
 Asn Cys Tyr Ser Asn Glu Thr Val Ile Leu Thr Pro Thr Met Asp Ser
                 190                 195                 200

 cga ctc tac atg ctc tcc ttc ctg ccc ttc ctg gtg ctg ctg gtc ctc      734
 Arg Leu Tyr Met Leu Ser Phe Leu Pro Phe Leu Val Leu Leu Val Leu
             205                 210                 215

 atc cgg aac ctc agg atc ttg acc atc ttc tcc atg ctg gcc aac atc      782
 Ile Arg Asn Leu Arg Ile Leu Thr Ile Phe Ser Met Leu Ala Asn Ile
         220                 225                 230

 agc atg ctg gtc agc ttg gtc atc atc ata cag tac att acc cag gaa      830
 Ser Met Leu Val Ser Leu Val Ile Ile Ile Gln Tyr Ile Thr Gln Glu
     235                 240                 245

 atc cca gac ccc agc cgg ttg cca ctg gta gca agc tgg aag acc tac      878
 Ile Pro Asp Pro Ser Arg Leu Pro Leu Val Ala Ser Trp Lys Thr Tyr
 250                 255                 260                 265

 cct ctc ttc ttc gga aca gcc att ttt tct ttt gaa agc att ggt gtg      926
 Pro Leu Phe Phe Gly Thr Ala Ile Phe Ser Phe Glu Ser Ile Gly Val
                 270                 275                 280

 gtt ctg cct ctg gaa aac aag atg aag aat gcc cgc cac ttc cca gcc      974
 Val Leu Pro Leu Glu Asn Lys Met Lys Asn Ala Arg His Phe Pro Ala
             285                 290                 295

 atc ctg tct ttg gga atg tcc atc gtc act tcc cta tac att ggc atg     1022
 Ile Leu Ser Leu Gly Met Ser Ile Val Thr Ser Leu Tyr Ile Gly Met
         300                 305                 310

 gcg gct ctg ggc tac ctg cgg ttt gga gat gac atc aag gcc agc ata     1070
 Ala Ala Leu Gly Tyr Leu Arg Phe Gly Asp Asp Ile Lys Ala Ser Ile
     315                 320                 325

 agc ctt aac ctg cct aac tgc tgg ctg tac cag tct gtc aag ctt ctc     1118
 Ser Leu Asn Leu Pro Asn Cys Trp Leu Tyr Gln Ser Val Lys Leu Leu
 330                 335                 340                 345

 tac att gcc ggc atc ctg tgc acc tat gcc ctg cag ttc tac gtc cct     1166
 Tyr Ile Ala Gly Ile Leu Cys Thr Tyr Ala Leu Gln Phe Tyr Val Pro
                 350                 355                 360

 gca gaa atc atc atc ccc ttt gcc atc tcc cgg gtg tca aca cgc tgg     1214
 Ala Glu Ile Ile Ile Pro Phe Ala Ile Ser Arg Val Ser Thr Arg Trp
             365                 370                 375

 gca ctg cct ctg gat ctg tcc att cgc ctc gtc atg gtc tgc ctg aca     1262
 Ala Leu Pro Leu Asp Leu Ser Ile Arg Leu Val Met Val Cys Leu Thr
         380                 385                 390

 taa tgaa tcacaatacc taaaaggata gtagccttca tctccatttt gcagctgagg     1319
 


 aaacaagctg aggaaggggt gggacttggg caaggccata caagaatgaa ccagactcct   1379

 gccttccaga cctgttctgt tctaccacac tcctccaaag gaggcctgct caaggctcct   1439

 gggatttatt ggtgaccagg aacatttttc atcaaatata ataaaaaatg taaaagccca   1499

 ggtctgtaaa acgtcctgct aaaaaaatat aatttcaaaa tttttaaaaa aaaaaaaa     1557




      <210> 568
      <211> 1961
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (194)..(1498)

      <400> 568
 gaggtaaccc tgaggtctgc ccaccctaca gatggggctt tgggggtttg ctccagagct     60

 cttcatccgc ctgggcccaa ccctggaact attcctttca atggtgtctt ttcttgcctt    120

 gtttcagaag gatctactag ttggccctat cttgtgccaa gactgacagc aaggaagctg    180

 ctggctgact gcc   atg tcc acg cag aga ctt cgg aat gaa gac tac cac     229
                  Met Ser Thr Gln Arg Leu Arg Asn Glu Asp Tyr His
                    1               5                  10

 gac tac agc tcc acg gac gtg agc cct gag gag agc ccg tcg gaa ggc      277
 Asp Tyr Ser Ser Thr Asp Val Ser Pro Glu Glu Ser Pro Ser Glu Gly
          15                  20                  25

 ctc aac aac ctc tcc tcc ccg ggc tcc tac cag cgc ttt ggt caa agc      325
 Leu Asn Asn Leu Ser Ser Pro Gly Ser Tyr Gln Arg Phe Gly Gln Ser
      30                  35                  40

 aat agc aca aca tgg ttc cag acc ttg atc cac ctg tta aaa ggc aac      373
 Asn Ser Thr Thr Trp Phe Gln Thr Leu Ile His Leu Leu Lys Gly Asn
  45                  50                  55                  60

 att ggc aca gga ctc ctg gga ctc cct ctg gcg gcg aaa aat gca ggc      421
 Ile Gly Thr Gly Leu Leu Gly Leu Pro Leu Ala Ala Lys Asn Ala Gly
                  65                  70                  75

 atc gtg atg ggt ccc atc agc ctg ctg atc ata ggc atc gtg gcc gtg      469
 Ile Val Met Gly Pro Ile Ser Leu Leu Ile Ile Gly Ile Val Ala Val
              80                  85                  90

 cac tgc atg ggt atc ctg gtg aaa tgt gct cac cac ttc tgc cgc agg      517
 His Cys Met Gly Ile Leu Val Lys Cys Ala His His Phe Cys Arg Arg
          95                 100                 105

 ctg aat aaa tcc ttt gtg gat tat ggt gat act gtg atg tat gga cta      565
 Leu Asn Lys Ser Phe Val Asp Tyr Gly Asp Thr Val Met Tyr Gly Leu
     110                 115                 120

 gaa tcc agc ccc tgc tcc tgg ctc cgg aac cac gca cac tgg gga aga      613
 Glu Ser Ser Pro Cys Ser Trp Leu Arg Asn His Ala His Trp Gly Arg
 125                 130                 135                 140

 cgt gtt gtg gac ttc ttc ctg att gtc acc cag ctg gga ttc tgc tgt      661
 Arg Val Val Asp Phe Phe Leu Ile Val Thr Gln Leu Gly Phe Cys Cys
                 145                 150                 155

 gtc tat ttt gtg ttt ctg gct gac aac ttt aaa cag gtg ata gaa gcg      709
 Val Tyr Phe Val Phe Leu Ala Asp Asn Phe Lys Gln Val Ile Glu Ala
             160                 165                 170

 gcc aat ggg acc acc aat aac tgc cac aac aat gag acg gtg att ctg      757
 Ala Asn Gly Thr Thr Asn Asn Cys His Asn Asn Glu Thr Val Ile Leu
         175                 180                 185

 acg cct acc atg gac tcg cga ctc tac atg ctc tcc ttc ctg ccc ttc      805
 Thr Pro Thr Met Asp Ser Arg Leu Tyr Met Leu Ser Phe Leu Pro Phe
     190                 195                 200

 ctg gtg ctg ctg gtt ttc atc agg aac ctc cga gcc ctg tcc atc ttc      853
 Leu Val Leu Leu Val Phe Ile Arg Asn Leu Arg Ala Leu Ser Ile Phe
 205                 210                 215                 220

 tcc ctg ttg gcc aac atc acc atg ctg gtc agc ttg gtc atg atc tac      901
 Ser Leu Leu Ala Asn Ile Thr Met Leu Val Ser Leu Val Met Ile Tyr
                 225                 230                 235

 cag ttc att gtt cag agg atc cca gac ccc agc cac ctc ccc ttg gtg      949
 Gln Phe Ile Val Gln Arg Ile Pro Asp Pro Ser His Leu Pro Leu Val
             240                 245                 250

 gcc cct tgg aag acc tac cct ctc ttc ttt ggc aca gcg att ttt tca      997
 Ala Pro Trp Lys Thr Tyr Pro Leu Phe Phe Gly Thr Ala Ile Phe Ser
         255                 260                 265

 ttt gaa ggc att gga atg gtt ctg ccc ctg gaa aac aaa atg aag gat     1045
 Phe Glu Gly Ile Gly Met Val Leu Pro Leu Glu Asn Lys Met Lys Asp
     270                 275                 280

 cct cgg aag ttc cca ctc atc ctg tac ctg ggc atg gtc atc gtc acc     1093
 Pro Arg Lys Phe Pro Leu Ile Leu Tyr Leu Gly Met Val Ile Val Thr
 285                 290                 295                 300

 atc ctc tac atc agc ctg ggg tgt ctg ggg tac ctg caa ttt gga gct     1141
 Ile Leu Tyr Ile Ser Leu Gly Cys Leu Gly Tyr Leu Gln Phe Gly Ala
                 305                 310                 315

 aat atc caa ggc agc ata acc ctc aac ctg ccc aac tgc tgg ttg tac     1189
 Asn Ile Gln Gly Ser Ile Thr Leu Asn Leu Pro Asn Cys Trp Leu Tyr
             320                 325                 330

 cag tca gtt aag ctg ctg tac tcc atc ggg atc ttt ttc acc tac gca     1237
 Gln Ser Val Lys Leu Leu Tyr Ser Ile Gly Ile Phe Phe Thr Tyr Ala
         335                 340                 345

 ctc cag ttc tac gtc ccg gct gag atc atc tcc ctg gtg ggc tcc gtg     1285
 Leu Gln Phe Tyr Val Pro Ala Glu Ile Ile Ser Leu Val Gly Ser Val
     350                 355                 360

 agc agc agc gcc ctg gcc ctc atc atc cca ccg ctc ctg gag gtc acc     1333
 Ser Ser Ser Ala Leu Ala Leu Ile Ile Pro Pro Leu Leu Glu Val Thr
 365                 370                 375                 380

 acc ttc tac tca gag ggc atg agc ccc ctc acc atc ttt aag gac gcc     1381
 Thr Phe Tyr Ser Glu Gly Met Ser Pro Leu Thr Ile Phe Lys Asp Ala
                 385                 390                 395

 ctg atc agc atc ctg ggc ttc gtg ggc ttt gtg gtg ggg acc tat gag     1429
 Leu Ile Ser Ile Leu Gly Phe Val Gly Phe Val Val Gly Thr Tyr Glu
             400                 405                 410

 gct ctc tat gag ctg atc cgg cca agc aat gct ccc atc ttc atc aat     1477
 Ala Leu Tyr Glu Leu Ile Arg Pro Ser Asn Ala Pro Ile Phe Ile Asn
         415                 420                 425

 tcc acc tgt gcc ttc ata tag gg atctgggttc gtctctgcag ctgcctaccc     1530
 Ser Thr Cys Ala Phe Ile 
     430

 ctgccccatg tgtcccccgt tacctgtcct cagagcctca ggtatggtcc aggctctgag   1590

 gaaagtcagg gttgctgtgt gggaacccct ctgcctggca cctggatacc ctgggccagg   1650

 taacctgagg gcaggggaga ggtggggtgg cagacacgca gaagtgctac tagtgacagg   1710

 gctgccatcg ctcacctgta cctatttaca cccagaactt tccagctccc cctcatcatg   1770

 cctcctcctt cctacctgcc tcccctctgc tggtgcacct cgcccaactc attcttactg   1830

 cacagttcac tttatttaac aattttcatg tcccccacct catgttttca ccttttctgg   1890

 gccaggcata gattaagtaa ctgggaacgc cccctcttta taaagctggg cttctttctc   1950

 atctctctcc c                                                        1961




      <210> 569
      <211> 1129
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (374)..(589)

      <400> 569
 agcgggaaaa aaaacttatc tgaggttgga aataaagaga aggtgacatt ggagcggata     60

 gaaaggaaga aacggcgtgg gatctgggaa tgaggcagtg ggtggagaga gaatggggag    120

 acgacagagg atgaagggca gctgagtgtg tctgcgggag aaggaccaaa gcaatctggg    180

 cggagcaggt ggcagaggca gccgcggagg aggcccaggg aactgacggg gatgctcagc    240

 caggcccaga ggatgcgccc tggcagtccc ggaagacacc aggaaaacaa gcaggaaccg    300

 tagctaggac tggggtggcc aggcccagga aatccatgaa gggcacagac agcgggtcct    360

 gctgccgccg ccg   atg cga ctt tgg ctg ctg ctg tcg cgc gtc ccg ccg     409
                  Met Arg Leu Trp Leu Leu Leu Ser Arg Val Pro Pro
                    1               5                  10

 ggc tca cta cac gcc tta ccg gtc cgg gga cgc gac gcg aac ccc tca      457
 Gly Ser Leu His Ala Leu Pro Val Arg Gly Arg Asp Ala Asn Pro Ser
          15                  20                  25

 gtc ccc acg gca gac ccc gag ccg gga aag acg gcg ccc gga gcc agc      505
 Val Pro Thr Ala Asp Pro Glu Pro Gly Lys Thr Ala Pro Gly Ala Ser
      30                  35                  40

 cgg gag ctg ggc agc agc ggc cga gga gga aga agc agc tgc ggc ggc      553
 Arg Glu Leu Gly Ser Ser Gly Arg Gly Gly Arg Ser Ser Cys Gly Gly
  45                  50                  55                  60

 cac acc ctg gat gag aga tta ttt tgc aga gga tga tggg gagatggtac      603
 His Thr Leu Asp Glu Arg Leu Phe Cys Arg Gly 
                  65                  70

 ccagaacgag tcacacagca gcttttctta gtgacactaa agatcgaggc cctccagtgc    663

 agtcacagat ctggagaagt ggtgaaaagg tcccgtttgt gcagacatat tccttgagag    723

 catttgagaa accccctcag gtacagaccc aggcctcttc gagactttga gaagcacctc    783

 aatgacctga agaaggagaa cttcagcctc aagctgcgca tctacttcct ggaggagcgc    843

 atgcaacaga agtatgaggc cagccgggag ggacatctac aagcggcaat tgcctaccca    903

 aaccctaggc ccagccgact ttggaggtct ccaggttgaa ccttcacctt ttacttggaa    963

 tggagcagtc tctgcaagag gggtggtgga agtaggaagc acaaaaattg agcaaagaac   1023

 agttagaaga ggaagtcctg cagggagcaa tgttatccaa gagagctata ttatatttga   1083

 acagacatca ttatgttgga taagttatca tatcttcgga gtgagg                  1129




      <210> 570
      <211> 1019
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (136)..(759)

      <400> 570
 gatgtgtgca aactaccctc cacctgggcg cgcgcgatgg acttggtacc cggcttccga     60

 agacaggccg tctgatggtt gaactactag cgcaggtggg cggtgagatg accaacccca    120

 cacacgcgct tctcc atg aag att ctt gag ctt tct ctg aag aaa gga gtg     171
                  Met Lys Ile Leu Glu Leu Ser Leu Lys Lys Gly Val
                    1               5                  10

 cat atg ctg cag tgt ctc tgt gga agg agc ctg agg tcc agc gac acg      219
 His Met Leu Gln Cys Leu Cys Gly Arg Ser Leu Arg Ser Ser Asp Thr
          15                  20                  25

 cca agt gaa ccc cag ctc aaa ggg att gtg aca agg tta tgc aac cgg      267
 Pro Ser Glu Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Cys Asn Arg
      30                  35                  40

 cag gga tac ttc ctg cag atg cac cca gat ggt acc att gat ggg acc      315
 Gln Gly Tyr Phe Leu Gln Met His Pro Asp Gly Thr Ile Asp Gly Thr
  45                  50                  55                  60

 aag gac gaa aac agc gac tac act ctc ttc aat cta att ccc gtg ggc      363
 Lys Asp Glu Asn Ser Asp Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly
                  65                  70                  75

 ctg cgt gta gtg gcc atc caa gga gtg aag gct agc ctc tat gtg gcc      411
 Leu Arg Val Val Ala Ile Gln Gly Val Lys Ala Ser Leu Tyr Val Ala
              80                  85                  90

 atg aat ggt gaa ggc tat ctc tac agt tca gat gtt ttc act cca gaa      459
 Met Asn Gly Glu Gly Tyr Leu Tyr Ser Ser Asp Val Phe Thr Pro Glu
          95                 100                 105

 tgc aaa ttc aag gaa tct gtg ttt gaa aac tac tat gtg atc tat tct      507
 Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile Tyr Ser
     110                 115                 120

 tcc aca ctg tac cgc cag caa gaa tca ggc cga gct tgg ttt ctg gga      555
 Ser Thr Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe Leu Gly
 125                 130                 135                 140

 ctc aat aaa gaa ggt caa att atg aag ggg aac aga gtg aag aaa acc      603
 Leu Asn Lys Glu Gly Gln Ile Met Lys Gly Asn Arg Val Lys Lys Thr
                 145                 150                 155

 aag ccc tca tca cat ttt gta ccg aaa cct att gaa gtg tgt atg tac      651
 Lys Pro Ser Ser His Phe Val Pro Lys Pro Ile Glu Val Cys Met Tyr
             160                 165                 170

 aga gaa cca tcg cta cat gaa att gga gaa aaa caa ggg cgt tca agg      699
 Arg Glu Pro Ser Leu His Glu Ile Gly Glu Lys Gln Gly Arg Ser Arg
         175                 180                 185

 aaa agt tct gga aca cca acc atg aat gga ggc aaa gtt gtg aat caa      747
 Lys Ser Ser Gly Thr Pro Thr Met Asn Gly Gly Lys Val Val Asn Gln
     190                 195                 200

 gat tca aca tag ctg agaactctcc ccttcttccc tctctcatcc cttccccttc      802
 Asp Ser Thr 
 205

 ccttccttcc catttaccca tttccttcca gtaaatccac ccaaggagag gaaaataaaa    862

 tgacaacgca agacctagtg gctaagattc tgcactcaaa atcttccttt gtgtaggaca    922

 agaaaattga accaaagctt gcttgttgca gtgtggtaaa taattcacgt gcacaaagat    982

 taagcacact tttatagcaa aggaaaaaat acatcag                            1019




      <210> 571
      <211> 832
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(577)

      <400> 571
 cgga atg gcg aaa gca aca aca atc aaa gaa gcc tta gcg aga tgg gaa      49
      Met Ala Lys Ala Thr Thr Ile Lys Glu Ala Leu Ala Arg Trp Glu
        1               5                  10                  15

 gag aaa act ggc cag agg cca tct gaa gcc aaa gag ata aaa ctt tat       97
 Glu Lys Thr Gly Gln Arg Pro Ser Glu Ala Lys Glu Ile Lys Leu Tyr
                  20                  25                  30

 gcc cag att ccc cct ata gag aag atg gat gca tcc ttg tcc atg ctt      145
 Ala Gln Ile Pro Pro Ile Glu Lys Met Asp Ala Ser Leu Ser Met Leu
              35                  40                  45

 gct aat tgc gag aag ctt tca ctg tct aca aac tgc att gaa aaa att      193
 Ala Asn Cys Glu Lys Leu Ser Leu Ser Thr Asn Cys Ile Glu Lys Ile
          50                  55                  60

 gcc aac ctg aat ggc tta aaa aac ttg agg ata tta tct tta gga aga      241
 Ala Asn Leu Asn Gly Leu Lys Asn Leu Arg Ile Leu Ser Leu Gly Arg
      65                  70                  75

 aac aac ata aag aac tta aat gga ctg gag gca gta ggg gac aca tta      289
 Asn Asn Ile Lys Asn Leu Asn Gly Leu Glu Ala Val Gly Asp Thr Leu
  80                  85                  90                  95

 gaa gaa ctg tgg atc tcc tac aat ttt att gag aag ttg aaa ggg atc      337
 Glu Glu Leu Trp Ile Ser Tyr Asn Phe Ile Glu Lys Leu Lys Gly Ile
                 100                 105                 110

 cac ata atg aag aaa ttg aag att ctc tac atg tct aat aac ctg gta      385
 His Ile Met Lys Lys Leu Lys Ile Leu Tyr Met Ser Asn Asn Leu Val
             115                 120                 125

 aaa gac tgg gct gag ttt gtg aag ctg gca gaa ctg cca tgc ctc gaa      433
 Lys Asp Trp Ala Glu Phe Val Lys Leu Ala Glu Leu Pro Cys Leu Glu
         130                 135                 140

 gac ctg gtg ttt gta ggc aat ccc ttg gaa gag aaa cat tct gct gag      481
 Asp Leu Val Phe Val Gly Asn Pro Leu Glu Glu Lys His Ser Ala Glu
     145                 150                 155

 aat aac tgg att gaa gaa gca acc aag aga gtg ccc aaa ctg aaa aag      529
 Asn Asn Trp Ile Glu Glu Ala Thr Lys Arg Val Pro Lys Leu Lys Lys
 160                 165                 170                 175

 ctg gat ggt act cca gta att aaa ggg gat gag gaa gaa gac aac taa      577
 Leu Asp Gly Thr Pro Val Ile Lys Gly Asp Glu Glu Glu Asp Asn 
                 180                 185                 190

 tgccacgctt tccactgtgt gttaacttat ttaaatgtca taagaacaat agataaattt    637

 tatataattg tctattttaa agattctgta tgggacaaaa gtttcttaag ataaaacaga    697

 tcactcattc tcatcttttt ttttccttta acttattcag tgtttctccc caaaactggt    757

 aatgccaacc ttatatatcc tatttctctt tttagaaacc acaaattttc gatttttgtc    817

 ttcagtctca gttac                                                     832




      <210> 572
      <211> 1817
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(1817)

      <400> 572
 cgtgttcact gtttagtagt actcaaaact gccagtgtga gaggatttgg aaatcactgg     60

 atctgctcaa tacaaaa   atg ttt ttt cga gtc ttt ctc cat ttt atc agg     110
                      Met Phe Phe Arg Val Phe Leu His Phe Ile Arg
                        1               5                  10

 agt cat tct gcc act gca gtg gat ttc ctt cct gtg atg gtg cac cgg      158
 Ser His Ser Ala Thr Ala Val Asp Phe Leu Pro Val Met Val His Arg
              15                  20                  25

 ctc cca gtt ttc aaa agg tac atg gga aat act cct cag aaa aaa gcc      206
 Leu Pro Val Phe Lys Arg Tyr Met Gly Asn Thr Pro Gln Lys Lys Ala
          30                  35                  40

 gtc ttt ggg cag tgt cgg ggt ctg cca tgt gtt gca ccg ctg ctg acc      254
 Val Phe Gly Gln Cys Arg Gly Leu Pro Cys Val Ala Pro Leu Leu Thr
      45                  50                  55

 aca gtg gaa gag gct cca cgg ggc atc tct gct cga gtc tgg gga cat      302
 Thr Val Glu Glu Ala Pro Arg Gly Ile Ser Ala Arg Val Trp Gly His
  60                  65                  70                  75

 ttt cct aag tgg ctc aat ggc tct cta ctt cga att gga cct ggg aaa      350
 Phe Pro Lys Trp Leu Asn Gly Ser Leu Leu Arg Ile Gly Pro Gly Lys
                  80                  85                  90

 ttc gag ttt ggg aag gat aag tac aat cat tgg ttt gat ggg atg gcg      398
 Phe Glu Phe Gly Lys Asp Lys Tyr Asn His Trp Phe Asp Gly Met Ala
              95                 100                 105

 ctg ctt cac cag ttc aga atg gca aag ggc aca gtg aca tac agg agc      446
 Leu Leu His Gln Phe Arg Met Ala Lys Gly Thr Val Thr Tyr Arg Ser
         110                 115                 120

 aag ttt cta cag agt gat aca tat aag gcc aac agt gct aaa aac cga      494
 Lys Phe Leu Gln Ser Asp Thr Tyr Lys Ala Asn Ser Ala Lys Asn Arg
     125                 130                 135

 att gtg atc tca gaa ttt ggc aca ctg gct ctc ccg gat cca tgc aag      542
 Ile Val Ile Ser Glu Phe Gly Thr Leu Ala Leu Pro Asp Pro Cys Lys
 140                 145                 150                 155

 aat gtt ttt gaa cgt ttc atg tcc agg ttt gag ctg cct ggt aaa gct      590
 Asn Val Phe Glu Arg Phe Met Ser Arg Phe Glu Leu Pro Gly Lys Ala
                 160                 165                 170

 gca gcc atg act gac aat act aat gtc aac tat gtg cgg tac aag ggt      638
 Ala Ala Met Thr Asp Asn Thr Asn Val Asn Tyr Val Arg Tyr Lys Gly
             175                 180                 185

 gat tac tac ctc tgc act gag acc aac ttt atg aat aaa gtg gac att      686
 Asp Tyr Tyr Leu Cys Thr Glu Thr Asn Phe Met Asn Lys Val Asp Ile
         190                 195                 200

 gaa act ctg gaa aaa aca gaa aag gta gat tgg agc aaa ttt att gct      734
 Glu Thr Leu Glu Lys Thr Glu Lys Val Asp Trp Ser Lys Phe Ile Ala
     205                 210                 215

 gtg aat gga gca act gca cat cct cat tat gac ctg gat gga aca gca      782
 Val Asn Gly Ala Thr Ala His Pro His Tyr Asp Leu Asp Gly Thr Ala
 220                 225                 230                 235

 tac aat atg ggg aac tcc ttt ggg cca tat ggt ttc tcc tat aag gtt      830
 Tyr Asn Met Gly Asn Ser Phe Gly Pro Tyr Gly Phe Ser Tyr Lys Val
                 240                 245                 250

 att cgg gtt cct cca gag gag gtg gac ctt ggg gag aca atc cat gga      878
 Ile Arg Val Pro Pro Glu Glu Val Asp Leu Gly Glu Thr Ile His Gly
             255                 260                 265

 gtc cag gtg ata tgt tct att gct tct aca gag aaa ggg aaa cct tct      926
 Val Gln Val Ile Cys Ser Ile Ala Ser Thr Glu Lys Gly Lys Pro Ser
         270                 275                 280

 tac tac cat agc ttt gga atg aca agg aac tat ata att ttc att gaa      974
 Tyr Tyr His Ser Phe Gly Met Thr Arg Asn Tyr Ile Ile Phe Ile Glu
     285                 290                 295

 caa cct cta aag atg aac ctg tgg aaa att gcc act tct aaa att cgg     1022
 Gln Pro Leu Lys Met Asn Leu Trp Lys Ile Ala Thr Ser Lys Ile Arg
 300                 305                 310                 315

 gga aag gcc ttt tca gat ggg ata agc tgg gaa ccc cag tgt aat acg     1070
 Gly Lys Ala Phe Ser Asp Gly Ile Ser Trp Glu Pro Gln Cys Asn Thr
                 320                 325                 330

 cgg ttt cat gtg gtg gaa aaa cgc act gga cag ctc ctt cca ggg aga     1118
 Arg Phe His Val Val Glu Lys Arg Thr Gly Gln Leu Leu Pro Gly Arg
             335                 340                 345

 tac tac agc aaa cct ttt gtt aca ttt cat caa atc aat gcc ttt gag     1166
 Tyr Tyr Ser Lys Pro Phe Val Thr Phe His Gln Ile Asn Ala Phe Glu
         350                 355                 360

 gac cag ggc tgt gtt ata att gat ttg tgc tgt caa gat aat gga aga     1214
 Asp Gln Gly Cys Val Ile Ile Asp Leu Cys Cys Gln Asp Asn Gly Arg
     365                 370                 375

 acc cta gaa gtt tac cag tta cag aat ctc agg aag gct ggg gaa ggg     1262
 Thr Leu Glu Val Tyr Gln Leu Gln Asn Leu Arg Lys Ala Gly Glu Gly
 380                 385                 390                 395

 ctt gat cag gtc cat aat tca gca gcc aaa tct ttc cct cga agg ttt     1310
 Leu Asp Gln Val His Asn Ser Ala Ala Lys Ser Phe Pro Arg Arg Phe
                 400                 405                 410

 gtt ttg cct tta aat gtc agt ttg aat gcc cct gag gga gac aac ctg     1358
 Val Leu Pro Leu Asn Val Ser Leu Asn Ala Pro Glu Gly Asp Asn Leu
             415                 420                 425

 agt cca ttg tcc tat act tca gcc agt gct gtg aaa cag gct gat gga     1406
 Ser Pro Leu Ser Tyr Thr Ser Ala Ser Ala Val Lys Gln Ala Asp Gly
         430                 435                 440

 acg atc tgc tgc tct cat gaa aat cta cat cag gag gac cta gaa aag     1454
 Thr Ile Cys Cys Ser His Glu Asn Leu His Gln Glu Asp Leu Glu Lys
     445                 450                 455

 gaa gga ggc att gaa ttt cct cag atc tac tat gat cga ttc agt ggc     1502
 Glu Gly Gly Ile Glu Phe Pro Gln Ile Tyr Tyr Asp Arg Phe Ser Gly
 460                 465                 470                 475

 aaa aag tat cat ttc ttt tat ggc tgt ggc ttt cgg cat tta gtg ggg     1550
 Lys Lys Tyr His Phe Phe Tyr Gly Cys Gly Phe Arg His Leu Val Gly
                 480                 485                 490

 gat tct ctg atc aag gtt gat gtg gtg aat aag aca ctg aag gtt tgg     1598
 Asp Ser Leu Ile Lys Val Asp Val Val Asn Lys Thr Leu Lys Val Trp
             495                 500                 505

 aga gaa gat ggc ttt tat ccc tca gaa cct gtt ttt gtt cca gca cca     1646
 Arg Glu Asp Gly Phe Tyr Pro Ser Glu Pro Val Phe Val Pro Ala Pro
         510                 515                 520

 gga acc aat gaa gaa gat ggt ggg gtt att ctt tct gtg gtg atc act     1694
 Gly Thr Asn Glu Glu Asp Gly Gly Val Ile Leu Ser Val Val Ile Thr
     525                 530                 535

 ccc aac cag aat gaa agc aat ttt ctc cta gtt ttg gat gcc aag aac     1742
 Pro Asn Gln Asn Glu Ser Asn Phe Leu Leu Val Leu Asp Ala Lys Asn
 540                 545                 550                 555

 ttt gaa gag ctg ggc cga gca gag gta cct gtg cag atg cct tat ggg     1790
 Phe Glu Glu Leu Gly Arg Ala Glu Val Pro Val Gln Met Pro Tyr Gly
                 560                 565                 570

 ttc cat ggt acc ttc ata ccc atc tga                                 1817
 Phe His Gly Thr Phe Ile Pro Ile 
             575





      <210> 573
      <211> 1763
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(1763)

      <400> 573
 cgtgttcact gtttagtagt actcaaaact gccagtgtga gaggatttgg aaatcactgg     60

 atctgctcaa tacaaaa   atg ttt ttt cga gtc ttt ctc cat ttt atc agg     110
                      Met Phe Phe Arg Val Phe Leu His Phe Ile Arg
                        1               5                  10

 agt cat tct gcc act gca gtg gat ttc ctt cct gtg atg gtg cac cgg      158
 Ser His Ser Ala Thr Ala Val Asp Phe Leu Pro Val Met Val His Arg
              15                  20                  25

 ctc cca gtt ttc aaa agg tac atg gga aat act cct cag aac aca gtg      206
 Leu Pro Val Phe Lys Arg Tyr Met Gly Asn Thr Pro Gln Asn Thr Val
          30                  35                  40

 gaa gag gct cca cgg ggc atc tct gct cga gtc tgg gga cat ttt cct      254
 Glu Glu Ala Pro Arg Gly Ile Ser Ala Arg Val Trp Gly His Phe Pro
      45                  50                  55

 aag tgg ctc aat ggc tct cta ctt cga att gga cct ggg aaa ttc gag      302
 Lys Trp Leu Asn Gly Ser Leu Leu Arg Ile Gly Pro Gly Lys Phe Glu
  60                  65                  70                  75

 ttt ggg aag gat aag tac aat cat tgg ttt gat ggg atg gcg ctg ctt      350
 Phe Gly Lys Asp Lys Tyr Asn His Trp Phe Asp Gly Met Ala Leu Leu
                  80                  85                  90

 cac cag ttc aga atg gca aag ggc aca gtg aca tac agg agc aag ttt      398
 His Gln Phe Arg Met Ala Lys Gly Thr Val Thr Tyr Arg Ser Lys Phe
              95                 100                 105

 cta cag agt gat aca tat aag gcc aac agt gct aaa aac cga att gtg      446
 Leu Gln Ser Asp Thr Tyr Lys Ala Asn Ser Ala Lys Asn Arg Ile Val
         110                 115                 120

 atc tca gaa ttt ggc aca ctg gct ctc ccg gat cca tgc aag aat gtt      494
 Ile Ser Glu Phe Gly Thr Leu Ala Leu Pro Asp Pro Cys Lys Asn Val
     125                 130                 135

 ttt gaa cgt ttc atg tcc agg ttt gag ctg cct ggt aaa gct gca gcc      542
 Phe Glu Arg Phe Met Ser Arg Phe Glu Leu Pro Gly Lys Ala Ala Ala
 140                 145                 150                 155

 atg act gac aat act aat gtc aac tat gtg cgg tac aag ggt gat tac      590
 Met Thr Asp Asn Thr Asn Val Asn Tyr Val Arg Tyr Lys Gly Asp Tyr
                 160                 165                 170

 tac ctc tgc act gag acc aac ttt atg aat aaa gtg gac att gaa act      638
 Tyr Leu Cys Thr Glu Thr Asn Phe Met Asn Lys Val Asp Ile Glu Thr
             175                 180                 185

 ctg gaa aaa aca gaa aag gta gat tgg agc aaa ttt att gct gtg aat      686
 Leu Glu Lys Thr Glu Lys Val Asp Trp Ser Lys Phe Ile Ala Val Asn
         190                 195                 200

 gga gca act gca cat cct cat tat gac ctg gat gga aca gca tac aat      734
 Gly Ala Thr Ala His Pro His Tyr Asp Leu Asp Gly Thr Ala Tyr Asn
     205                 210                 215

 atg ggg aac tcc ttt ggg cca tat ggt ttc tcc tat aag gtt att cgg      782
 Met Gly Asn Ser Phe Gly Pro Tyr Gly Phe Ser Tyr Lys Val Ile Arg
 220                 225                 230                 235

 gtt cct cca gag gag gtg gac ctt ggg gag aca atc cat gga gtc cag      830
 Val Pro Pro Glu Glu Val Asp Leu Gly Glu Thr Ile His Gly Val Gln
                 240                 245                 250

 gtg ata tgt tct att gct tct aca gag aaa ggg aaa cct tct tac tac      878
 Val Ile Cys Ser Ile Ala Ser Thr Glu Lys Gly Lys Pro Ser Tyr Tyr
             255                 260                 265

 cat agc ttt gga atg aca agg aac tat ata att ttc att gaa caa cct      926
 His Ser Phe Gly Met Thr Arg Asn Tyr Ile Ile Phe Ile Glu Gln Pro
         270                 275                 280

 cta aag atg aac ctg tgg aaa att gcc act tct aaa att cgg gga aag      974
 Leu Lys Met Asn Leu Trp Lys Ile Ala Thr Ser Lys Ile Arg Gly Lys
     285                 290                 295

 gcc ttt tca gat ggg ata agc tgg gaa ccc cag tgt aat acg cgg ttt     1022
 Ala Phe Ser Asp Gly Ile Ser Trp Glu Pro Gln Cys Asn Thr Arg Phe
 300                 305                 310                 315

 cat gtg gtg gaa aaa cgc act gga cag ctc ctt cca ggg aga tac tac     1070
 His Val Val Glu Lys Arg Thr Gly Gln Leu Leu Pro Gly Arg Tyr Tyr
                 320                 325                 330

 agc aaa cct ttt gtt aca ttt cat caa atc aat gcc ttt gag gac cag     1118
 Ser Lys Pro Phe Val Thr Phe His Gln Ile Asn Ala Phe Glu Asp Gln
             335                 340                 345

 ggc tgt gtt ata att gat ttg tgc tgt caa gat aat gga aga acc cta     1166
 Gly Cys Val Ile Ile Asp Leu Cys Cys Gln Asp Asn Gly Arg Thr Leu
         350                 355                 360

 gaa gtt tac cag tta cag aat ctc agg aag gct ggg gaa ggg ctt gat     1214
 Glu Val Tyr Gln Leu Gln Asn Leu Arg Lys Ala Gly Glu Gly Leu Asp
     365                 370                 375

 cag gtc cat aat tca gca gcc aaa tct ttc cct cga agg ttt gtt ttg     1262
 Gln Val His Asn Ser Ala Ala Lys Ser Phe Pro Arg Arg Phe Val Leu
 380                 385                 390                 395

 cct tta aat gtc agt ttg aat gcc cct gag gga gac aac ctg agt cca     1310
 Pro Leu Asn Val Ser Leu Asn Ala Pro Glu Gly Asp Asn Leu Ser Pro
                 400                 405                 410

 ttg tcc tat act tca gcc agt gct gtg aaa cag gct gat gga acg atc     1358
 Leu Ser Tyr Thr Ser Ala Ser Ala Val Lys Gln Ala Asp Gly Thr Ile
             415                 420                 425

 tgc tgc tct cat gaa aat cta cat cag gag gac cta gaa aag gaa gga     1406
 Cys Cys Ser His Glu Asn Leu His Gln Glu Asp Leu Glu Lys Glu Gly
         430                 435                 440

 ggc att gaa ttt cct cag atc tac tat gat cga ttc agt ggc aaa aag     1454
 Gly Ile Glu Phe Pro Gln Ile Tyr Tyr Asp Arg Phe Ser Gly Lys Lys
     445                 450                 455

 tat cat ttc ttt tat ggc tgt ggc ttt cgg cat tta gtg ggg gat tct     1502
 Tyr His Phe Phe Tyr Gly Cys Gly Phe Arg His Leu Val Gly Asp Ser
 460                 465                 470                 475

 ctg atc aag gtt gat gtg gtg aat aag aca ctg aag gtt tgg aga gaa     1550
 Leu Ile Lys Val Asp Val Val Asn Lys Thr Leu Lys Val Trp Arg Glu
                 480                 485                 490

 gat ggc ttt tat ccc tca gaa cct gtt ttt gtt cca gca cca gga acc     1598
 Asp Gly Phe Tyr Pro Ser Glu Pro Val Phe Val Pro Ala Pro Gly Thr
             495                 500                 505

 aat gaa gaa gat ggt ggg gtt att ctt tct gtg gtg atc act ccc aac     1646
 Asn Glu Glu Asp Gly Gly Val Ile Leu Ser Val Val Ile Thr Pro Asn
         510                 515                 520

 cag aat gaa agc aat ttt ctc cta gtt ttg gat gcc aag aac ttt gaa     1694
 Gln Asn Glu Ser Asn Phe Leu Leu Val Leu Asp Ala Lys Asn Phe Glu
     525                 530                 535

 gag ctg ggc cga gca gag gta cct gtg cag atg cct tat ggg ttc cat     1742
 Glu Leu Gly Arg Ala Glu Val Pro Val Gln Met Pro Tyr Gly Phe His
 540                 545                 550                 555

 ggt acc ttc ata ccc atc tga                                         1763
 Gly Thr Phe Ile Pro Ile 
                 560





      <210> 574
      <211> 830
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (17)..(709)

      <400> 574
 gaagagcagt gtcata    atg caa atg gga aga ttt ctt ctc tta gta att      49
                      Met Gln Met Gly Arg Phe Leu Leu Leu Val Ile
                        1               5                  10

 tta ttt ctg cca cgt gag atg aca agt tct gtt tta act gtg aat ggt       97
 Leu Phe Leu Pro Arg Glu Met Thr Ser Ser Val Leu Thr Val Asn Gly
              15                  20                  25

 aaa act gag aac tac atc ctg gat act aca cct ggc tcc caa gca tct      145
 Lys Thr Glu Asn Tyr Ile Leu Asp Thr Thr Pro Gly Ser Gln Ala Ser
          30                  35                  40

 ctg ata tgt gct gtt caa aac cac acc aga gag gaa gaa ctg ctc tgg      193
 Leu Ile Cys Ala Val Gln Asn His Thr Arg Glu Glu Glu Leu Leu Trp
      45                  50                  55

 tac cga gag gag ggg aga gtg gat ttg aaa tct gga aac aaa atc aat      241
 Tyr Arg Glu Glu Gly Arg Val Asp Leu Lys Ser Gly Asn Lys Ile Asn
  60                  65                  70                  75

 tcc agc tct gtc tgt gtc tct tcc atc agt gaa aat gac aac gga atc      289
 Ser Ser Ser Val Cys Val Ser Ser Ile Ser Glu Asn Asp Asn Gly Ile
                  80                  85                  90

 agc ttt acc tgc agg ctg ggg agg gat cag tcc gtg tcc gtt tcg gtg      337
 Ser Phe Thr Cys Arg Leu Gly Arg Asp Gln Ser Val Ser Val Ser Val
              95                 100                 105

 gtg ctg aat gtt act ttt cct cct ctc cta agt gga aac gac ttc caa      385
 Val Leu Asn Val Thr Phe Pro Pro Leu Leu Ser Gly Asn Asp Phe Gln
         110                 115                 120

 aca gtt gag gaa ggc agt aat ctg aag ttg gtt tgc aat gtg aaa gcc      433
 Thr Val Glu Glu Gly Ser Asn Leu Lys Leu Val Cys Asn Val Lys Ala
     125                 130                 135

 aac ccc cag gct caa atg atg tgg tac aaa aac agt agt ctc ctc gat      481
 Asn Pro Gln Ala Gln Met Met Trp Tyr Lys Asn Ser Ser Leu Leu Asp
 140                 145                 150                 155

 tta gag aaa agc cgt cac caa atc caa cag aca agt gag tct ttt cag      529
 Leu Glu Lys Ser Arg His Gln Ile Gln Gln Thr Ser Glu Ser Phe Gln
                 160                 165                 170

 ctg tca atc acc aaa gtc gag aag cct gac aac gga acc tac agt tgt      577
 Leu Ser Ile Thr Lys Val Glu Lys Pro Asp Asn Gly Thr Tyr Ser Cys
             175                 180                 185

 atg gca aag tca tct ctg aaa acg gag agc ttg gac ttt cac ctg att      625
 Met Ala Lys Ser Ser Leu Lys Thr Glu Ser Leu Asp Phe His Leu Ile
         190                 195                 200

 gtt aaa gat aaa act gtg ggt gta cca ata gag ccc att att gct gca      673
 Val Lys Asp Lys Thr Val Gly Val Pro Ile Glu Pro Ile Ile Ala Ala
     205                 210                 215

 tgt gtt gtg atc ttt ctg aca ttg tgc ttg gac tga ttgc tagaagaaag      723
 Cys Val Val Ile Phe Leu Thr Leu Cys Leu Asp 
 220                 225                 230

 aacataatga agctctgctt gaaggataaa gaccctcaca gtgaaacagc tctatgagaa    783

 agctgagatg ccatcgaata acgagagagt ttgcatcagg acctcca                  830




      <210> 575
      <211> 484
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(264)

      <400> 575
 ttttttataa tgccaacttt gtacaaaaaa gcaggctccg cgcgcgcccc cttcacc        57                                                                 
 atg aga aac ttg gtt agt ggc tct ctt ggc atg ttc gta gcc ctg tgg      105
 Met Arg Asn Leu Val Ser Gly Ser Leu Gly Met Phe Val Ala Leu Trp
   1               5                  10                  15

 atg aag tgg ctg aaa cct gcg ttg agc ctc agt cca agc agc tgg ggc      153
 Met Lys Trp Leu Lys Pro Ala Leu Ser Leu Ser Pro Ser Ser Trp Gly
              20                  25                  30

 cac acc agt ttg caa aag cgg atg tgg cag ttt cca ccg cag cag cag      201
 His Thr Ser Leu Gln Lys Arg Met Trp Gln Phe Pro Pro Gln Gln Gln
          35                  40                  45

 cct gct ggc gcc tca tca gat tct cct ttg gag gaa gta tct tct tcc      249
 Pro Ala Gly Ala Ser Ser Asp Ser Pro Leu Glu Glu Val Ser Ser Ser
      50                  55                  60

 ctt cat tct cgg tga atggcatcca gagataacca aaatcaggtg tatctagttt      304
 Leu His Ser Arg 
  65

 caagttctgt cttgcaaccg tgataattgg aggatgcaaa ctttacactt tcttctctag    364

 ctgtctacca ccactgctgc gcttgtggat gactgcagga acaccgggta cttgccacaa    424

 gtatctctcc agattcatca gcctttcacc tgtgacaagc tcagtcaaga agtggcttaa    484




      <210> 576
      <211> 1102
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (257)..(1102)

      <400> 576
 cctgtcctgg atttgtcctc tagatctttg caaggagatg gggggggatc aagatggatt     60

 tgggataaaa ttaaagtgac gtctgcaaaa acaaaacaaa aacaaaagca aacaggtgaa    120

 aaatgatgat tgtggcttcc ttgctaactg ggttagagaa gtgatcaagt gtgaaccggg    180

 acttgaatga gaggagtgac ttagcatttg gtgactgtcc ttaacgaaga actgtgcgct    240

 cctgggcgaa gaaaca    atg atg gag cag gaa atg acc cgg tta cat cgg     289
                      Met Met Glu Gln Glu Met Thr Arg Leu His Arg
                        1               5                  10

 aga gtg tca gag gtg gag gct gtg ctt agt cag aag gag gtg gag ctg      337
 Arg Val Ser Glu Val Glu Ala Val Leu Ser Gln Lys Glu Val Glu Leu
              15                  20                  25

 aag gcc tct gag act cag aga tcc ctc ctg gag cag gac ctt gct acc      385
 Lys Ala Ser Glu Thr Gln Arg Ser Leu Leu Glu Gln Asp Leu Ala Thr
          30                  35                  40

 tac atc aca gaa tgc agt agc tta aag cga agt ttg gag caa gca cgg      433
 Tyr Ile Thr Glu Cys Ser Ser Leu Lys Arg Ser Leu Glu Gln Ala Arg
      45                  50                  55

 atg gag gtg tcc cag gag gat gac aaa gca ctg cag ctt ctc cat gat      481
 Met Glu Val Ser Gln Glu Asp Asp Lys Ala Leu Gln Leu Leu His Asp
  60                  65                  70                  75

 atc aga gag cag agc cgg aag ctc caa gaa atc aaa gag cag gag tac      529
 Ile Arg Glu Gln Ser Arg Lys Leu Gln Glu Ile Lys Glu Gln Glu Tyr
                  80                  85                  90

 cag gct caa gtg gaa gaa atg agg ttg atg atg aat cag ttg gaa gag      577
 Gln Ala Gln Val Glu Glu Met Arg Leu Met Met Asn Gln Leu Glu Glu
              95                 100                 105

 gat ctt gtc tca gca aga aga cgg agt gat ctc tac gaa tct gag ctg      625
 Asp Leu Val Ser Ala Arg Arg Arg Ser Asp Leu Tyr Glu Ser Glu Leu
         110                 115                 120

 aga gag tct cgg ctt gct gct gaa gaa ttc aag cgg aaa gcg aca gaa      673
 Arg Glu Ser Arg Leu Ala Ala Glu Glu Phe Lys Arg Lys Ala Thr Glu
     125                 130                 135

 tgt cag cat aaa ctg ttg aag gct aag gat caa ggg aag cct gaa gtg      721
 Cys Gln His Lys Leu Leu Lys Ala Lys Asp Gln Gly Lys Pro Glu Val
 140                 145                 150                 155

 gga gaa tat gcg aaa ctg gag aag atc aat gct gag cag cag ctc aaa      769
 Gly Glu Tyr Ala Lys Leu Glu Lys Ile Asn Ala Glu Gln Gln Leu Lys
                 160                 165                 170

 att cag gag ctc caa gag aaa ctg gag aag gct gta aaa gcc agc acg      817
 Ile Gln Glu Leu Gln Glu Lys Leu Glu Lys Ala Val Lys Ala Ser Thr
             175                 180                 185

 gag gcc acc gag ctg ctg cag aat atc cgc cag gca aag gag cga gcc      865
 Glu Ala Thr Glu Leu Leu Gln Asn Ile Arg Gln Ala Lys Glu Arg Ala
         190                 195                 200

 gag agg gag ctg gag aag ctg cag aac cga gag gat tct tct gaa ggc      913
 Glu Arg Glu Leu Glu Lys Leu Gln Asn Arg Glu Asp Ser Ser Glu Gly
     205                 210                 215

 atc aga aag aag ctg gtg gaa gct gag gaa cgc cgc cat tct ctg gag      961
 Ile Arg Lys Lys Leu Val Glu Ala Glu Glu Arg Arg His Ser Leu Glu
 220                 225                 230                 235

 aac aag gta aag aga cta gag acc atg gag cgt aga gaa aac aga ctg     1009
 Asn Lys Val Lys Arg Leu Glu Thr Met Glu Arg Arg Glu Asn Arg Leu
                 240                 245                 250

 aag gat gac atc cag aca aaa tcc caa cag atc cag cag atg gct gat     1057
 Lys Asp Asp Ile Gln Thr Lys Ser Gln Gln Ile Gln Gln Met Ala Asp
             255                 260                 265

 aaa att ctg gtg agc agg aat gaa agt cgc aaa gtt aaa aga taa         1102
 Lys Ile Leu Val Ser Arg Asn Glu Ser Arg Lys Val Lys Arg 
         270                 275                 280





      <210> 577
      <211> 1417
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(1417)

      <400> 577
 cacacatcca gtaagtggcc gaagcagatc ttcagaccca cagtttggct gccaaaggac     60

 cacagtgagt atttctaatg ctgaaacaag agggtgcagc tctgcagccc agacggctgg    120

 gcctcaggga accctcccag cctcc  atg ccg cct ttc ctg atc acc ctc ttc     172
                              Met Pro Pro Phe Leu Ile Thr Leu Phe
                                1               5

 ctc ttt cac tct tgc tgc ctc cga gca aat ggc cac ctc cgt gaa gga      220
 Leu Phe His Ser Cys Cys Leu Arg Ala Asn Gly His Leu Arg Glu Gly
  10                  15                  20                  25

 atg aca ttg ctg aag act gag ttt gca ctt cac ctc tac cag agt gtg      268
 Met Thr Leu Leu Lys Thr Glu Phe Ala Leu His Leu Tyr Gln Ser Val
                  30                  35                  40

 gcc gcg tgt aga aat gag acg aac ttt gtc atc tct cct gct ggt gtg      316
 Ala Ala Cys Arg Asn Glu Thr Asn Phe Val Ile Ser Pro Ala Gly Val
              45                  50                  55

 tcc ctc ccc ctg gag atc ctg cag ttt gga gca gaa ggg agc act ggt      364
 Ser Leu Pro Leu Glu Ile Leu Gln Phe Gly Ala Glu Gly Ser Thr Gly
          60                  65                  70

 cag cag ctg gca gat gcc ctg ggg tac act gtc cat gct cac cct gct      412
 Gln Gln Leu Ala Asp Ala Leu Gly Tyr Thr Val His Ala His Pro Ala
      75                  80                  85

 gct cag gct acc tgg gag ata ggg agc tca gct ccc tat ggt gtg cac      460
 Ala Gln Ala Thr Trp Glu Ile Gly Ser Ser Ala Pro Tyr Gly Val His
  90                  95                 100                 105

 atg ggg aag agt gat cac tgg aca gac aaa agg gtg aaa gat ttc ttg      508
 Met Gly Lys Ser Asp His Trp Thr Asp Lys Arg Val Lys Asp Phe Leu
                 110                 115                 120

 cat gct gtt tat gcc aca cta ccc acc tcc agc caa ggc acc gag atg      556
 His Ala Val Tyr Ala Thr Leu Pro Thr Ser Ser Gln Gly Thr Glu Met
             125                 130                 135

 gag ctg gcc tgc agc ctt ttt gtg caa gtg gga acg cca ctg tcc ccc      604
 Glu Leu Ala Cys Ser Leu Phe Val Gln Val Gly Thr Pro Leu Ser Pro
         140                 145                 150

 tgc ttt gtg gag cac gtc tcc tgg tgg gct aac agc agc ctg gaa cca      652
 Cys Phe Val Glu His Val Ser Trp Trp Ala Asn Ser Ser Leu Glu Pro
     155                 160                 165

 gcc gac ctc agt gag ccc aat agc acc gcc atc cag act agc gaa ggg      700
 Ala Asp Leu Ser Glu Pro Asn Ser Thr Ala Ile Gln Thr Ser Glu Gly
 170                 175                 180                 185

 gcc tcc aga gag act gca ggt ggg ggc ccc agt gag ggc cct ggt ggc      748
 Ala Ser Arg Glu Thr Ala Gly Gly Gly Pro Ser Glu Gly Pro Gly Gly
                 190                 195                 200

 tgg ccg tgg gag caa gtc agt gca gca ttt gct cag ctt gtg ctt gtg      796
 Trp Pro Trp Glu Gln Val Ser Ala Ala Phe Ala Gln Leu Val Leu Val
             205                 210                 215

 agc acc atg tcc ttc caa ggc act tgg cga aag aga ttc tcc tcc aca      844
 Ser Thr Met Ser Phe Gln Gly Thr Trp Arg Lys Arg Phe Ser Ser Thr
         220                 225                 230

 gac aca cag atc ctg cct ttc acc tgt gcc tat ggc ctc gtc ctt cag      892
 Asp Thr Gln Ile Leu Pro Phe Thr Cys Ala Tyr Gly Leu Val Leu Gln
     235                 240                 245

 gtc ccc atg atg cac caa acg acc gag gtc aac tac ggt cag ttc cag      940
 Val Pro Met Met His Gln Thr Thr Glu Val Asn Tyr Gly Gln Phe Gln
 250                 255                 260                 265

 gac act gca ggc cat cag gtg ggg gtg ctg gag ctt cct tac ctg gga      988
 Asp Thr Ala Gly His Gln Val Gly Val Leu Glu Leu Pro Tyr Leu Gly
                 270                 275                 280

 agt gca gtg agt ctg ttc ctg gtg ctg ccc cgt gac aaa gac acc ccc     1036
 Ser Ala Val Ser Leu Phe Leu Val Leu Pro Arg Asp Lys Asp Thr Pro
             285                 290                 295

 ctg agc cac atc gag cca cac ctc aca gcc agc acc atc cac ctc tgg     1084
 Leu Ser His Ile Glu Pro His Leu Thr Ala Ser Thr Ile His Leu Trp
         300                 305                 310

 acc acc agc ctg agg aga gcc agg atg gat gtg ttc ctg ccc agg ttt     1132
 Thr Thr Ser Leu Arg Arg Ala Arg Met Asp Val Phe Leu Pro Arg Phe
     315                 320                 325

 agg atc caa aat caa ttc aac tta aaa agc att tta aat tct tgg gga     1180
 Arg Ile Gln Asn Gln Phe Asn Leu Lys Ser Ile Leu Asn Ser Trp Gly
 330                 335                 340                 345

 gtc acc gat ctt ttt gat cca ctc aaa gct aac ttg aaa gga att tca     1228
 Val Thr Asp Leu Phe Asp Pro Leu Lys Ala Asn Leu Lys Gly Ile Ser
                 350                 355                 360

 ggc caa gat ggc ttt tat gtt tct gaa gca atc cac aag gcc aag att     1276
 Gly Gln Asp Gly Phe Tyr Val Ser Glu Ala Ile His Lys Ala Lys Ile
             365                 370                 375

 gaa gtt ttg gag gaa ggc acc aag gca tct gga gcc aca gct ctg ttg     1324
 Glu Val Leu Glu Glu Gly Thr Lys Ala Ser Gly Ala Thr Ala Leu Leu
         380                 385                 390

 tta ttg aaa agg tct cgg att cct att ttt aaa gca gat cgg cca ttc     1372
 Leu Leu Lys Arg Ser Arg Ile Pro Ile Phe Lys Ala Asp Arg Pro Phe
     395                 400                 405

 atc tat ttc ctg aga gaa cct aac aca gct ttc tta tca ttt tag         1417
 Ile Tyr Phe Leu Arg Glu Pro Asn Thr Ala Phe Leu Ser Phe 
 410                 415                 420





      <210> 578
      <211> 301
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(235)

      <400> 578
 caagcttttt taaaacggca actttgaaca aaaagcaggc tccgcgcccc cccccttcac     60

 c    atg gtg gtt ggc atc ctc ctg gaa gtg ata gca atc ttt gtg gcc     106
      Met Val Val Gly Ile Leu Leu Glu Val Ile Ala Ile Phe Val Ala
        1               5                  10                  15

 acc gtt ggc atg aag tgt atg aag tgc ttg gaa gac gat gag gtg cag      154
 Thr Val Gly Met Lys Cys Met Lys Cys Leu Glu Asp Asp Glu Val Gln
                  20                  25                  30

 aag atg agg atg gct gtc att ggg ggc gcg ata ttt ctt ctt gca ggt      202
 Lys Met Arg Met Ala Val Ile Gly Gly Ala Ile Phe Leu Leu Ala Gly
              35                  40                  45

 aat aga ggc tgt ggc ccc ctt tca cct tac taa cctgttcc tggtaaaggg      253
 Asn Arg Gly Cys Gly Pro Leu Ser Pro Tyr 
          50                  55

 tgggcgcgcc gacccagctt tcttgtacaa agttggcatt ataagaaa                 301




      <210> 579
      <211> 873
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(737)

      <400> 579
 cagtggtaac aacgcacaga ccgggtgctg ctggtctgtg tgctctgagg gagggtccag     60

 gccatgtgct gcctccaggg gagcccctca ggctatggtc agcattaata   atg tct     116
                                                          Met Ser
                                                            1

 ttc atc tgt gag tgg atc tac aat ggc ttc tac agt gtg ctc cag ttt      164
 Phe Ile Cys Glu Trp Ile Tyr Asn Gly Phe Tyr Ser Val Leu Gln Phe
           5                  10                  15

 cta gga ctc tac aag aaa tct aga aaa ctt gtt ctc ttg ggt tgg gac      212
 Leu Gly Leu Tyr Lys Lys Ser Arg Lys Leu Val Leu Leu Gly Trp Asp
      20                  25                  30

 aat gtg gat gaa acc att ctt cct cat atg ctc aaa gat ggt gga ttg      260
 Asn Val Asp Glu Thr Ile Leu Pro His Met Leu Lys Asp Gly Gly Leu
  35                  40                  45                  50

 ggc caa cag gct cca aca cga cct ctg cca tca gca gag ctg aca act      308
 Gly Gln Gln Ala Pro Thr Arg Pro Leu Pro Ser Ala Glu Leu Thr Thr
                  55                  60                  65

 gct agc ctg gct ttt acg act ttt gat ctt ctg ggg cat aag caa aca      356
 Ala Ser Leu Ala Phe Thr Thr Phe Asp Leu Leu Gly His Lys Gln Thr
              70                  75                  80

 cgt tgg att tgg aac agt gat ctc cca gca aca aat ggg att gcc ttt      404
 Arg Trp Ile Trp Asn Ser Asp Leu Pro Ala Thr Asn Gly Ile Ala Phe
          85                  90                  95

 ctg ggt tac tgt gca gat tgt cct cag atc ctg gaa tcc aaa gag gag      452
 Leu Gly Tyr Cys Ala Asp Cys Pro Gln Ile Leu Glu Ser Lys Glu Glu
     100                 105                 110

 ctc aat gct tta atg act gat gaa aga ata tcc cat gtg cca gtc ctt      500
 Leu Asn Ala Leu Met Thr Asp Glu Arg Ile Ser His Val Pro Val Leu
 115                 120                 125                 130

 atc ttg att agc aaa cat tgg aca gaa cag gca caa tca gtg aag aaa      548
 Ile Leu Ile Ser Lys His Trp Thr Glu Gln Ala Gln Ser Val Lys Lys
                 135                 140                 145

 aac tct gtc tgc cat ttg gtc ttt atg gac aga cca cag gaa agg gaa      596
 Asn Ser Val Cys His Leu Val Phe Met Asp Arg Pro Gln Glu Arg Glu
             150                 155                 160

 ctt gtg acc ctg aag gag cca aat gcc ttt tcc aag gaa tcg ttc acg      644
 Leu Val Thr Leu Lys Glu Pro Asn Ala Phe Ser Lys Glu Ser Phe Thr
         165                 170                 175

 ctc agt gtg tac aac aac agg gct atg gca agg gct tct gct ggt ttg      692
 Leu Ser Val Tyr Asn Asn Arg Ala Met Ala Arg Ala Ser Ala Gly Leu
     180                 185                 190

 ccc agt ata ttg act gat ggt tgg gca gtg aaa ata aaa gtt taa ctt      740
 Pro Ser Ile Leu Thr Asp Gly Trp Ala Val Lys Ile Lys Val 
 195                 200                 205

 tttaaaaaaa aaagatggtg ggtggggagg gagtaaacag tctaggcttc ttctgcaaga    800

 gaagaagtaa aagggaatag cactctacac tcaaagattt taaaagtcca atccctgggc    860

 gaaatcgtcg acc                                                       873




      <210> 580
      <211> 1459
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (87)..(1286)

      <400> 580
 ggcgggggcg aggcgggagt ggcggtgcca gcggagggca ccggcccggc gtggcagcgg     60

 cggcggagcg cggccccggg cacacc atg gcc gag ctg ctg cgg agc ctg cag     113
                              Met Ala Glu Leu Leu Arg Ser Leu Gln
                                1               5

 gat tcc cag ctc gtc gcc cgc ttc cag cgc cgc tgc ggg ctc ttc ccc      161
 Asp Ser Gln Leu Val Ala Arg Phe Gln Arg Arg Cys Gly Leu Phe Pro
  10                  15                  20                  25

 gct ccg gat gaa ggc ccc cgg gag aac ggc gcg gac ccc acg gag cgc      209
 Ala Pro Asp Glu Gly Pro Arg Glu Asn Gly Ala Asp Pro Thr Glu Arg
                  30                  35                  40

 gcg gcg cgg gtc ccc ggg gtc gag cat ctc ccc gca gcc aac ggc aag      257
 Ala Ala Arg Val Pro Gly Val Glu His Leu Pro Ala Ala Asn Gly Lys
              45                  50                  55

 ggc ggc gag gct ccg gcc aac ggg ctg cgc aga gcc gcg gcg ccg gag      305
 Gly Gly Glu Ala Pro Ala Asn Gly Leu Arg Arg Ala Ala Ala Pro Glu
          60                  65                  70

 gct tat gta cag aag tac gtc gtg aag aat tat ttc tac tat tac cta      353
 Ala Tyr Val Gln Lys Tyr Val Val Lys Asn Tyr Phe Tyr Tyr Tyr Leu
      75                  80                  85

 ttc caa ttt tca gct gct ttg ggc caa gaa gtg ttc tac atc acg ttt      401
 Phe Gln Phe Ser Ala Ala Leu Gly Gln Glu Val Phe Tyr Ile Thr Phe
  90                  95                 100                 105

 ctt cca ttc act cac tgg aat att gac cct tat tta tcc aga aga ttg      449
 Leu Pro Phe Thr His Trp Asn Ile Asp Pro Tyr Leu Ser Arg Arg Leu
                 110                 115                 120

 atc atc ata tgg gtt ttg gtg atg tat att ggc caa gtg gcc aag gat      497
 Ile Ile Ile Trp Val Leu Val Met Tyr Ile Gly Gln Val Ala Lys Asp
             125                 130                 135

 gtc ttg aag tgg ccc cgt ccc tcc tcc cct cca gtt gta aaa ctg gaa      545
 Val Leu Lys Trp Pro Arg Pro Ser Ser Pro Pro Val Val Lys Leu Glu
         140                 145                 150

 aag aga ctg atc gct gaa tat gga atg cca tcc acc cac gcc atg gcg      593
 Lys Arg Leu Ile Ala Glu Tyr Gly Met Pro Ser Thr His Ala Met Ala
     155                 160                 165

 gcc act gcc att gcc ttc acc ctc ctt atc tct act atg gac aga tac      641
 Ala Thr Ala Ile Ala Phe Thr Leu Leu Ile Ser Thr Met Asp Arg Tyr
 170                 175                 180                 185

 cag tat cca ttt gtg ttg gga ctg gtg atg gcc gtg gtg ttt tcc acc      689
 Gln Tyr Pro Phe Val Leu Gly Leu Val Met Ala Val Val Phe Ser Thr
                 190                 195                 200

 ttg gtg tgt ctc agc agg ctc tac act ggg atg cat acg gtc ctg gat      737
 Leu Val Cys Leu Ser Arg Leu Tyr Thr Gly Met His Thr Val Leu Asp
             205                 210                 215

 gtg ctg ggt ggc gtc ctg atc acc gca ctc ctc atc gtc ctc acc tac      785
 Val Leu Gly Gly Val Leu Ile Thr Ala Leu Leu Ile Val Leu Thr Tyr
         220                 225                 230

 cct gcc tgg acc ttc atc gac tgc ctg gac tcg gcc agc ccc ctc ttc      833
 Pro Ala Trp Thr Phe Ile Asp Cys Leu Asp Ser Ala Ser Pro Leu Phe
     235                 240                 245

 ccc gtg tgt gtc ata gtt gtg cca ttc ttc ctg tgt tac aat tac cct      881
 Pro Val Cys Val Ile Val Val Pro Phe Phe Leu Cys Tyr Asn Tyr Pro
 250                 255                 260                 265

 gtt tct gat tac tac agc cca acc cgg gcg gac acc acc acc att ctg      929
 Val Ser Asp Tyr Tyr Ser Pro Thr Arg Ala Asp Thr Thr Thr Ile Leu
                 270                 275                 280

 gct gcc ggg gct gga gtg acc ata gga ttc tgg atc aac cat ttc ttc      977
 Ala Ala Gly Ala Gly Val Thr Ile Gly Phe Trp Ile Asn His Phe Phe
             285                 290                 295

 cag ctt gta tcc aag ccc gct gaa tct ctc cct gtt att cag aac atc     1025
 Gln Leu Val Ser Lys Pro Ala Glu Ser Leu Pro Val Ile Gln Asn Ile
         300                 305                 310

 cca ccg ctc acc acc tac atg tta gtt ttg ggt ctg acc aaa ttt gca     1073
 Pro Pro Leu Thr Thr Tyr Met Leu Val Leu Gly Leu Thr Lys Phe Ala
     315                 320                 325

 gtg gga att gtg ttg atc ctc ttg gtt cgt cag ctt gta caa aat ctc     1121
 Val Gly Ile Val Leu Ile Leu Leu Val Arg Gln Leu Val Gln Asn Leu
 330                 335                 340                 345

 tca ctg caa gta tta tac tca tgg ttc aag gtg gtc acc agg aac aag     1169
 Ser Leu Gln Val Leu Tyr Ser Trp Phe Lys Val Val Thr Arg Asn Lys
                 350                 355                 360

 gag gcc agg cgg aga ctg gag att gaa gtg cct tac aag ttt gtt acc     1217
 Glu Ala Arg Arg Arg Leu Glu Ile Glu Val Pro Tyr Lys Phe Val Thr
             365                 370                 375

 tac aca tct gtt ggc atc tgc gct aca acc ttt gtg ccg atg ctt cac     1265
 Tyr Thr Ser Val Gly Ile Cys Ala Thr Thr Phe Val Pro Met Leu His
         380                 385                 390

 agg ttt ctg gga tta ccc tga gt ctcaaacagt tggaaactag cccactggac     1318
 Arg Phe Leu Gly Leu Pro 
     395

 atgaaagcca agacatagga aagttattgg taggcaaatc ttgacaactt atttttcttt   1378

 aacaacaaca aaaagtcata cggctgtctt gctactacca gataaatgat gctgctgtgt   1438

 gaaaggaaaa aaaaaaaaaa a                                             1459




      <210> 581
      <211> 2793
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2079)

      <400> 581
  atg agg gca gct ctc tgg acc ctg gga ctc ggg ccc ctt ctt ctg aat      48
  Met Arg Ala Ala Leu Trp Thr Leu Gly Leu Gly Pro Leu Leu Leu Asn
    1               5                  10                  15

 ctc tgg gca gtc tct gta ggt gga cca ggt gct ctg agg ctg gcg tac       96
 Leu Trp Ala Val Ser Val Gly Gly Pro Gly Ala Leu Arg Leu Ala Tyr
              20                  25                  30

 aga cac agc acg tgc gac gga gtg gtg ttg gtc cga cac cac ggg gca      144
 Arg His Ser Thr Cys Asp Gly Val Val Leu Val Arg His His Gly Ala
          35                  40                  45

 tgg gga tac gtg tgc aac cag gag tgg acg ctg gca gag gcc tct gtc      192
 Trp Gly Tyr Val Cys Asn Gln Glu Trp Thr Leu Ala Glu Ala Ser Val
      50                  55                  60

 gtg tgc agg cag ctg ggc tgc ggc cct gcc gtg ggc gcc ccc aag tat      240
 Val Cys Arg Gln Leu Gly Cys Gly Pro Ala Val Gly Ala Pro Lys Tyr
  65                  70                  75                  80

 gtc ccg ctg cct gga gag atg gcc cag ccc tgg ctt cac aac gtg tcc      288
 Val Pro Leu Pro Gly Glu Met Ala Gln Pro Trp Leu His Asn Val Ser
                  85                  90                  95

 tgc cgg ggc aac gag tcc tcc ctc tgg gag tgc agc ctt ggc tca tgg      336
 Cys Arg Gly Asn Glu Ser Ser Leu Trp Glu Cys Ser Leu Gly Ser Trp
             100                 105                 110

 tgc cag agc ccg tgc ccc cac gca tgg gtg gtg gtc gcg ctg tgc tcc      384
 Cys Gln Ser Pro Cys Pro His Ala Trp Val Val Val Ala Leu Cys Ser
         115                 120                 125

 aga cac acc gag gcc cga ctg gtg ggc ggc gag cac ccc tgc gcc ggg      432
 Arg His Thr Glu Ala Arg Leu Val Gly Gly Glu His Pro Cys Ala Gly
     130                 135                 140

 cgc ctg gag gtg acc tgg ggc acc gtc tgt gat gcg gcc ctg gac ctg      480
 Arg Leu Glu Val Thr Trp Gly Thr Val Cys Asp Ala Ala Leu Asp Leu
 145                 150                 155                 160

 gcc acg gcc cac gtg gtg tgc cgg gag ctg cag tgt ggg gcg gtc gtg      528
 Ala Thr Ala His Val Val Cys Arg Glu Leu Gln Cys Gly Ala Val Val
                 165                 170                 175

 tcc acg ccc gag ggc gcc cgc ttc ggc cgg ggc tcg ggg ccg gtg tgg      576
 Ser Thr Pro Glu Gly Ala Arg Phe Gly Arg Gly Ser Gly Pro Val Trp
             180                 185                 190

 acg gag gcc ttc cgc tgt gcg ggc aac gag tcg ctg ctg ttc cac tgc      624
 Thr Glu Ala Phe Arg Cys Ala Gly Asn Glu Ser Leu Leu Phe His Cys
         195                 200                 205

 cca cgg ggg cgt ggg agc cag tgt ggg cat ggt cac gac gcg ggg ctc      672
 Pro Arg Gly Arg Gly Ser Gln Cys Gly His Gly His Asp Ala Gly Leu
     210                 215                 220

 agg tgc tca gag ttc agg atg gtc aac ggc agc agc agc tgt gag ggc      720
 Arg Cys Ser Glu Phe Arg Met Val Asn Gly Ser Ser Ser Cys Glu Gly
 225                 230                 235                 240

 cgc gtg gag ttc cag gtg cag ggg tcc tgg gca ccc ctc tgt gcc acc      768
 Arg Val Glu Phe Gln Val Gln Gly Ser Trp Ala Pro Leu Cys Ala Thr
                 245                 250                 255

 cac tgg gac ata gca gat gcc acc gtc ctc tgc cac cag ctc aac tgt      816
 His Trp Asp Ile Ala Asp Ala Thr Val Leu Cys His Gln Leu Asn Cys
             260                 265                 270

 ggc aac gcg gtg gcc gca cct gga gga ggc cat ttt ggg gac ggg gac      864
 Gly Asn Ala Val Ala Ala Pro Gly Gly Gly His Phe Gly Asp Gly Asp
         275                 280                 285

 gct gcc atc tgg cct gat gcc ttt cac tgt gag ggg aca gag tcc tac      912
 Ala Ala Ile Trp Pro Asp Ala Phe His Cys Glu Gly Thr Glu Ser Tyr
     290                 295                 300

 ttg tgg aat tgc cca gta agc acc ctg ggg gcc ccg gcc tgt gcc ccg      960
 Leu Trp Asn Cys Pro Val Ser Thr Leu Gly Ala Pro Ala Cys Ala Pro
 305                 310                 315                 320

 gga aac aca gcc tcc gcg gtc tgc tca ggt ggg tgc agc cag gac ggt     1008
 Gly Asn Thr Ala Ser Ala Val Cys Ser Gly Gly Cys Ser Gln Asp Gly
                 325                 330                 335

 gga cca gga ggg cag ggc act ccc tgg cct gac tgt gct tgc ctt gca     1056
 Gly Pro Gly Gly Gln Gly Thr Pro Trp Pro Asp Cys Ala Cys Leu Ala
             340                 345                 350

 gag tcg gtg gct ctg agg ctg cga ggt ggg acc tgc tgc tgt gct ggg     1104
 Glu Ser Val Ala Leu Arg Leu Arg Gly Gly Thr Cys Cys Cys Ala Gly
         355                 360                 365

 tgg ctg gac gtg ttc tac aat ggg acc tgg ggc gcc atg tgc agc aat     1152
 Trp Leu Asp Val Phe Tyr Asn Gly Thr Trp Gly Ala Met Cys Ser Asn
     370                 375                 380

 gcc ctg aag gac ctc tcc ttg tcc atc atc tgc aag cag ctg ggg tgt     1200
 Ala Leu Lys Asp Leu Ser Leu Ser Ile Ile Cys Lys Gln Leu Gly Cys
 385                 390                 395                 400

 ggg ggg gag tgg ggc tgg ctg gag aac agg ccc ttc ccc tct gcg ggc     1248
 Gly Gly Glu Trp Gly Trp Leu Glu Asn Arg Pro Phe Pro Ser Ala Gly
                 405                 410                 415

 acc ggg acc gcc tgg gtg gac aac atc gag tgc cgc agg ctg ccc aac     1296
 Thr Gly Thr Ala Trp Val Asp Asn Ile Glu Cys Arg Arg Leu Pro Asn
             420                 425                 430

 tcc act ctg tgg caa tgc cct tcc cac cca tgg cac ccg cac tct tgc     1344
 Ser Thr Leu Trp Gln Cys Pro Ser His Pro Trp His Pro His Ser Cys
         435                 440                 445

 gac ctt cga gag cag gtc tgg att acc tgt gca gcc ccc gca gtg acc     1392
 Asp Leu Arg Glu Gln Val Trp Ile Thr Cys Ala Ala Pro Ala Val Thr
     450                 455                 460

 gca gcc cct ttt gca gag gag ggc gca ctg cgc gtg cgc ggg ggc gag     1440
 Ala Ala Pro Phe Ala Glu Glu Gly Ala Leu Arg Val Arg Gly Gly Glu
 465                 470                 475                 480

 gac cgc tgc tcc ggg cgc gtg gag ctc tgg cac gcg ggc tcc tgg ggc     1488
 Asp Arg Cys Ser Gly Arg Val Glu Leu Trp His Ala Gly Ser Trp Gly
                 485                 490                 495

 acc gtg tgc gac gat ggc tgg gac ctg gcg gac gcg gag gtc gtg tgc     1536
 Thr Val Cys Asp Asp Gly Trp Asp Leu Ala Asp Ala Glu Val Val Cys
             500                 505                 510

 cgc cag ctg ggc tgt ggt cgg gcc gtc gcc gcc ctg ggg gcc gcc gcc     1584
 Arg Gln Leu Gly Cys Gly Arg Ala Val Ala Ala Leu Gly Ala Ala Ala
         515                 520                 525

 ttt ggc cct ggc tcc ggg ccc gtg tgg ctg gac gag gtg ggg tgc cgg     1632
 Phe Gly Pro Gly Ser Gly Pro Val Trp Leu Asp Glu Val Gly Cys Arg
     530                 535                 540

 ggc agc gag gcg tcc ctg tgg ggc tgc cct gcg gag cgg tgg gga cgc     1680
 Gly Ser Glu Ala Ser Leu Trp Gly Cys Pro Ala Glu Arg Trp Gly Arg
 545                 550                 555                 560

 gga gac cgc gcg cac gag gag gac gcg ggc gtg cgc tgc tgg gct ccc     1728
 Gly Asp Arg Ala His Glu Glu Asp Ala Gly Val Arg Cys Trp Ala Pro
                 565                 570                 575

 ttc cgg aca ttc tgg gtg gtc agt gtc gtc ctg gga tcc ctt ctt ggt     1776
 Phe Arg Thr Phe Trp Val Val Ser Val Val Leu Gly Ser Leu Leu Gly
             580                 585                 590

 ctt ctc ctt ctg ggc ctc atg gct ttt ctg att ctg cct cga gtc aca     1824
 Leu Leu Leu Leu Gly Leu Met Ala Phe Leu Ile Leu Pro Arg Val Thr
         595                 600                 605

 caa gcc atg cag agg ggt ctg gga aga tcc gag gta tct cct gga gaa     1872
 Gln Ala Met Gln Arg Gly Leu Gly Arg Ser Glu Val Ser Pro Gly Glu
     610                 615                 620

 gcc atc tat gat gtc att ggg gaa atg ccg cta gca gga ctg tac gag     1920
 Ala Ile Tyr Asp Val Ile Gly Glu Met Pro Leu Ala Gly Leu Tyr Glu
 625                 630                 635                 640

 gaa atc atg gag gcc gag gct gtg ctc caa gat gag gag gac gga agt     1968
 Glu Ile Met Glu Ala Glu Ala Val Leu Gln Asp Glu Glu Asp Gly Ser
                 645                 650                 655

 gtg gtg aag gtg gac aca gaa gcc gca gtt tca ggg gag gtg tct aac     2016
 Val Val Lys Val Asp Thr Glu Ala Ala Val Ser Gly Glu Val Ser Asn
             660                 665                 670

 ctc ctg gag gga cag tct ata cgt gcg gag gga gga cac agc aga cct     2064
 Leu Leu Glu Gly Gln Ser Ile Arg Ala Glu Gly Gly His Ser Arg Pro
         675                 680                 685

 gtt tct cag gga tga cgaggctgcg tttcctctgg aggagatgac gttgtaaagc     2119
 Val Ser Gln Gly 
     690

 aacctgagga tgagatacac cagctggctg tcgaaatcac agctcttcat tttcttgtac   2179

 aattgtagtg gatttcgtga gaacaccttg gatgcctttc tcttgcaatg tcctccatgt   2239

 ccatgtaaaa tccagtcctt ccaggccctg cctggctcta aacctcatcc ccttcgaggg   2299

 ccatctgctg tggacagttg tgctgtgtaa ccttcagatt tcccacacat tacagcaaat   2359

 gcaaatacac atagaaatca gtggttccat ttgtggttta gagacacatg gtgccatctt   2419

 catcttccgc tccacagctc gcttctggca cccagcagtg ggttgcagag ctccccatgc   2479

 cagaaccttc ctcttttttc ttaaaaactc ttcttaattg aatccaaagt atcttttaaa   2539

 tgttctactt gtgtaatcat gtcatctgtg aatattcaga tttatcttct ccttccaatc   2599

 cgtgtacatt taatctcttt ttctgtgcct tatttcgggg gctgggaccc ttcagtccag   2659

 tgttgaagag aggcagccag tggaggtctt gtctcattca aggactcaga gcaaatgtgt   2719

 tccacattta atttcactat gaaatataat atttgatgtt cagttttgta gatgctattt   2779

 atcagatcaa ggaa                                                     2793




      <210> 582
      <211> 2251
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2028)

      <400> 582
  atg agg gca gct ctc tgg acc ctg gga ctc ggg ccc ctt ctt ctg aat      48
  Met Arg Ala Ala Leu Trp Thr Leu Gly Leu Gly Pro Leu Leu Leu Asn
    1               5                  10                  15

 ctc tgg gca gtc tct gta ggt gga cca ggt gct ctg agg ctg gcg tac       96
 Leu Trp Ala Val Ser Val Gly Gly Pro Gly Ala Leu Arg Leu Ala Tyr
              20                  25                  30

 aga cac agc acg tgc gac gga gtg gtg ttg gtc cga cac cac ggg gca      144
 Arg His Ser Thr Cys Asp Gly Val Val Leu Val Arg His His Gly Ala
          35                  40                  45

 tgg gga tac gtg tgc aac cag gag tgg acg ctg gca gag gcc tct gtc      192
 Trp Gly Tyr Val Cys Asn Gln Glu Trp Thr Leu Ala Glu Ala Ser Val
      50                  55                  60

 gtg tgc agg cag ctg ggc tgc ggc cct gcc gtg ggc gcc ccc aag tat      240
 Val Cys Arg Gln Leu Gly Cys Gly Pro Ala Val Gly Ala Pro Lys Tyr
  65                  70                  75                  80

 gtc ccg ctg cct gga gag atg gcc cag ccc tgg ctt cac aac gtg tcc      288
 Val Pro Leu Pro Gly Glu Met Ala Gln Pro Trp Leu His Asn Val Ser
                  85                  90                  95

 tgc cgg ggc aac gag tcc tcc ctc tgg gag tgc agc ctt ggc tca tgg      336
 Cys Arg Gly Asn Glu Ser Ser Leu Trp Glu Cys Ser Leu Gly Ser Trp
             100                 105                 110

 tgc cag agc ccg tgc ccc cac gca tgg gtg gtg gtc gcg ctg tgc tcc      384
 Cys Gln Ser Pro Cys Pro His Ala Trp Val Val Val Ala Leu Cys Ser
         115                 120                 125

 aga cac acc gag gcc cga ctg gtg ggc ggc gag cac ccc tgc gcc ggg      432
 Arg His Thr Glu Ala Arg Leu Val Gly Gly Glu His Pro Cys Ala Gly
     130                 135                 140

 cgc ctg gag gtg acc tgg ggc acc gtc tgt gat gcg gcc ctg gac ctg      480
 Arg Leu Glu Val Thr Trp Gly Thr Val Cys Asp Ala Ala Leu Asp Leu
 145                 150                 155                 160

 gcc acg gcc cac gtg gtg tgc cgg gag ctg cag tgt ggg gcg gtc gtg      528
 Ala Thr Ala His Val Val Cys Arg Glu Leu Gln Cys Gly Ala Val Val
                 165                 170                 175

 tcc acg ccc gag ggc gcc cgc ttc ggc cgg ggc tcg ggg ccg gtg tgg      576
 Ser Thr Pro Glu Gly Ala Arg Phe Gly Arg Gly Ser Gly Pro Val Trp
             180                 185                 190

 acg gag gcc ttc cgc tgt gcg ggc aac gag tcg ctg ctg ttc cac tgc      624
 Thr Glu Ala Phe Arg Cys Ala Gly Asn Glu Ser Leu Leu Phe His Cys
         195                 200                 205

 cca cgg ggg cgt ggg agc cag tgt ggg cat ggt cac gac gcg ggg ctc      672
 Pro Arg Gly Arg Gly Ser Gln Cys Gly His Gly His Asp Ala Gly Leu
     210                 215                 220

 agg tgc tca gag ttc agg atg gtc aac ggc agc agc agc tgt gag ggc      720
 Arg Cys Ser Glu Phe Arg Met Val Asn Gly Ser Ser Ser Cys Glu Gly
 225                 230                 235                 240

 cgc gtg gag ttc cag gtg cag ggg tcc tgg gca ccc ctc tgt gcc acc      768
 Arg Val Glu Phe Gln Val Gln Gly Ser Trp Ala Pro Leu Cys Ala Thr
                 245                 250                 255

 cac tgg gac ata gca gat gcc acc gtc ctc tgc cac cag ctc aac tgt      816
 His Trp Asp Ile Ala Asp Ala Thr Val Leu Cys His Gln Leu Asn Cys
             260                 265                 270

 ggc aac gcg gtg gcc gca cct gga gga ggc cat ttt ggg gac ggg gac      864
 Gly Asn Ala Val Ala Ala Pro Gly Gly Gly His Phe Gly Asp Gly Asp
         275                 280                 285

 gct gcc atc tgg cct gat gcc ttt cac tgt gag ggg aca gag tcc tac      912
 Ala Ala Ile Trp Pro Asp Ala Phe His Cys Glu Gly Thr Glu Ser Tyr
     290                 295                 300

 ttg tgg aat tgc cca gta agc acc ctg ggg gcc ccg gcc tgt gcc ccg      960
 Leu Trp Asn Cys Pro Val Ser Thr Leu Gly Ala Pro Ala Cys Ala Pro
 305                 310                 315                 320

 gga aac aca gcc tcc gcg gtc tgc tca ggt ggg tgc agc cag gac ggt     1008
 Gly Asn Thr Ala Ser Ala Val Cys Ser Gly Gly Cys Ser Gln Asp Gly
                 325                 330                 335

 gga cca gga ggg cag ggc act ccc tgg cct gac tgt gct tgc ctt gca     1056
 Gly Pro Gly Gly Gln Gly Thr Pro Trp Pro Asp Cys Ala Cys Leu Ala
             340                 345                 350

 gag tcg gtg gct ctg agg ctg cga ggt ggg acc tgc tgc tgt gct ggg     1104
 Glu Ser Val Ala Leu Arg Leu Arg Gly Gly Thr Cys Cys Cys Ala Gly
         355                 360                 365

 tgg ctg gac gtg ttc tac aat ggg acc tgg ggc gcc atg tgc agc aat     1152
 Trp Leu Asp Val Phe Tyr Asn Gly Thr Trp Gly Ala Met Cys Ser Asn
     370                 375                 380

 gcc ctg aag gac ctc tcc ttg tcc atc atc tgc aag cag ctg ggg tgt     1200
 Ala Leu Lys Asp Leu Ser Leu Ser Ile Ile Cys Lys Gln Leu Gly Cys
 385                 390                 395                 400

 ggg ggg gag tgg ggc tgg ctg gag aac agg ccc ttc ccc tct gcg ggc     1248
 Gly Gly Glu Trp Gly Trp Leu Glu Asn Arg Pro Phe Pro Ser Ala Gly
                 405                 410                 415

 acc ggg acc gcc tgg gtg gac aac atc gag tgc cgc agg ctg ccc aac     1296
 Thr Gly Thr Ala Trp Val Asp Asn Ile Glu Cys Arg Arg Leu Pro Asn
             420                 425                 430

 tcc act ctg tgg caa tgc cct tcc cac cca tgg cac ccg cac tct tgc     1344
 Ser Thr Leu Trp Gln Cys Pro Ser His Pro Trp His Pro His Ser Cys
         435                 440                 445

 gac ctt cga gag cag gtc tgg att acc tgt gca gcc ccc gca gtg acc     1392
 Asp Leu Arg Glu Gln Val Trp Ile Thr Cys Ala Ala Pro Ala Val Thr
     450                 455                 460

 gca gcc cct ttt gca gag gag ggc gca ctg cgc gtg cgc ggg ggc gag     1440
 Ala Ala Pro Phe Ala Glu Glu Gly Ala Leu Arg Val Arg Gly Gly Glu
 465                 470                 475                 480

 gac cgc tgc tcc ggg cgc gtg gag ctc tgg cac gcg ggc tcc tgg ggc     1488
 Asp Arg Cys Ser Gly Arg Val Glu Leu Trp His Ala Gly Ser Trp Gly
                 485                 490                 495

 acc gtg tgc gac gat ggc tgg gac ctg gcg gac gcg gag gtc gtg tgc     1536
 Thr Val Cys Asp Asp Gly Trp Asp Leu Ala Asp Ala Glu Val Val Cys
             500                 505                 510

 cgc cag ctg ggc tgt ggt cgg gcc gtc gcc gcc ctg ggg gcc gcc gcc     1584
 Arg Gln Leu Gly Cys Gly Arg Ala Val Ala Ala Leu Gly Ala Ala Ala
         515                 520                 525

 ttt ggc cct ggc tcc ggg ccc gtg tgg ctg gac gag gtg ggg tgc cgg     1632
 Phe Gly Pro Gly Ser Gly Pro Val Trp Leu Asp Glu Val Gly Cys Arg
     530                 535                 540

 ggc agc gag gcg tcc ctg tgg ggc tgc cct gcg gag cgg tgg gga cgc     1680
 Gly Ser Glu Ala Ser Leu Trp Gly Cys Pro Ala Glu Arg Trp Gly Arg
 545                 550                 555                 560

 gga gac cgc gcg cac gag gag gac gcg ggc gtg cgc tgc tgg gct ccc     1728
 Gly Asp Arg Ala His Glu Glu Asp Ala Gly Val Arg Cys Trp Ala Pro
                 565                 570                 575

 ttc cgg aca ttc tgg gtg gtc agt gtc gtc ctg gga tcc ctt ctt ggt     1776
 Phe Arg Thr Phe Trp Val Val Ser Val Val Leu Gly Ser Leu Leu Gly
             580                 585                 590

 ctt ctc ctt ctg ggc ctc atg gct ttt ctg att ctg cct cga gtc aca     1824
 Leu Leu Leu Leu Gly Leu Met Ala Phe Leu Ile Leu Pro Arg Val Thr
         595                 600                 605

 caa gcc atg cag agg ggt ctg gga aga tcc gag gta tct cct gga gaa     1872
 Gln Ala Met Gln Arg Gly Leu Gly Arg Ser Glu Val Ser Pro Gly Glu
     610                 615                 620

 gcc atc tat gat gtc att ggg gaa atg ccg cta gca gga ctg tac gag     1920
 Ala Ile Tyr Asp Val Ile Gly Glu Met Pro Leu Ala Gly Leu Tyr Glu
 625                 630                 635                 640

 gaa atc atg gag gcc gag gct gtg ctc caa gat gag gag gac gga agt     1968
 Glu Ile Met Glu Ala Glu Ala Val Leu Gln Asp Glu Glu Asp Gly Ser
                 645                 650                 655

 gtg gtg aag gtg gac aca gaa gcc gca ggt tgc ctg ttc act ctg atg     2016
 Val Val Lys Val Asp Thr Glu Ala Ala Gly Cys Leu Phe Thr Leu Met
             660                 665                 670

 acc tat caa tga tag actggataaa gaaaatgtgg cacatataca ccatggaata     2071
 Thr Tyr Gln 
         675

 ttatgcagcc agaaaaaagg atgaattcat gtcctttgca gggacgtgga tgaagctgga   2131

 aaacatcgtt ctcagcaaac taacactgga acagaaaacc aaacactgca tgttctcact   2191

 cataagtggg agttgaacaa tgagaacaca tggacacggg gaggggaaca tcacacactg   2251




      <210> 583
      <211> 403
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (50)..(259)

      <400> 583
 atggcagagg cggtaacgga gagcatccct gaacggccag aaacgcgaa    atg ctg      55
                                                          Met Leu
                                                            1

 tcg gcc ttc cag agg ctg ttc cga gtc tta ttt gtg att gaa aca gtc      103
 Ser Ala Phe Gln Arg Leu Phe Arg Val Leu Phe Val Ile Glu Thr Val
           5                  10                  15

 tca gaa tac gga gtc ctg atc ttc att tat gga tgg ccc ttt ctc cag      151
 Ser Glu Tyr Gly Val Leu Ile Phe Ile Tyr Gly Trp Pro Phe Leu Gln
      20                  25                  30

 acc ctt gcg atg ctc ctg atc ggg aca gtg tct ttc cac ctt tgg atc      199
 Thr Leu Ala Met Leu Leu Ile Gly Thr Val Ser Phe His Leu Trp Ile
  35                  40                  45                  50

 cgc aga aat cga gag aga aac tca agg agc gga aag act aga tgc cga      247
 Arg Arg Asn Arg Glu Arg Asn Ser Arg Ser Gly Lys Thr Arg Cys Arg
                  55                  60                  65

 tcc aaa agg tga cca gccaccaagt aaagcactga tggtttcaga atgtgcctaa      302
 Ser Lys Arg 


 acctgcacca gtgaggcaag tatgcaaaag gagtcccttt ccgggatgga cacacttccc    362

 atggagccgt gtcaccccgc acagggttgc aaccaggctg g                        403




      <210> 584
      <211> 2274
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (466)..(888)

      <400> 584
 aattttcggg tcgacgattt cgtgggctcg gctccgcact gctagctgcg cgccgccctg     60

 gacggggcgc accgactgcg cgcgcggctg cgggcaaaca tcgggagtcc tgcctcagct    120

 gccgcttctc cagcagcagc ttcaggcttc tcccgcagga gcttcgggct tctcctggta    180

 gagacgtggg aacttttctt ctcctggcga ggctgcagag gtgatgggcc gctcccgggg    240

 ctcccgcggg gaggcggcac ggtgagcgtc ctcgggctcc ggtgcggcga tcagtaccta    300

 gttccggacg cgccggtccg acttggatgc cggctctagt cgagtcttct gagctacgat    360

 aattttttgg aacggcagaa atgattggtt ctagcaacag atgggaattt ggagtcactc    420

 tgaaatatat cctggaataa gtgtgtttga ctagaaccac atctt    atg agg tcc     474
                                                      Met Arg Ser
                                                        1

 cca agg atg aga gtc tgt gct aag tca gtg ttg ctg tcg cac tgg ctc      522
 Pro Arg Met Arg Val Cys Ala Lys Ser Val Leu Leu Ser His Trp Leu
       5                  10                  15

 ttt cta gcc tac gtg tta atg gtg tgc tgt aag ctg atg tcc gcc tca      570
 Phe Leu Ala Tyr Val Leu Met Val Cys Cys Lys Leu Met Ser Ala Ser
  20                  25                  30                  35

 agc cag cac ctc cgg gga cat gca ggt cac cac caa atc aag caa ggg      618
 Ser Gln His Leu Arg Gly His Ala Gly His His Gln Ile Lys Gln Gly
                  40                  45                  50

 acc tgt gag gtg gtc gcc gtg cac agg tgc tgc aat aag aac cgc ata      666
 Thr Cys Glu Val Val Ala Val His Arg Cys Cys Asn Lys Asn Arg Ile
              55                  60                  65

 gaa gag cgg tca caa acg gtc aag tgc tct tgc ttc ccg gga cag gtg      714
 Glu Glu Arg Ser Gln Thr Val Lys Cys Ser Cys Phe Pro Gly Gln Val
          70                  75                  80

 gcg ggc aca act cgg gct caa cct tct tgt gtt gaa gct tcc att gtg      762
 Ala Gly Thr Thr Arg Ala Gln Pro Ser Cys Val Glu Ala Ser Ile Val
      85                  90                  95

 att cag aaa tgg tgg tgt cac atg aat ccg tgt ttg gaa gga gag gat      810
 Ile Gln Lys Trp Trp Cys His Met Asn Pro Cys Leu Glu Gly Glu Asp
 100                 105                 110                 115

 tgt aaa gtg ctg cca gat tac tca ggt tgg tcc tgt agc agt ggc aat      858
 Cys Lys Val Leu Pro Asp Tyr Ser Gly Trp Ser Cys Ser Ser Gly Asn
                 120                 125                 130

 aaa gtc aaa act acg aag gta acg cgg tag c gaagagagag gtgtgcttca      909
 Lys Val Lys Thr Thr Lys Val Thr Arg 
             135                 140

 atcctggagg ggcagcagga ggcggagctc ttttgcttgg attcccatac atggcccctc    969

 tgcagaaaat tgtctaggat ttcagcaact tcatatttgt atattgtgag ctgtgagaag   1029

 gtggcattca cttaactggc ccagccctct ctgcttcgtg attttatttc attgaattat   1089

 aaccacaagc cacaacccat ttgacatcct ctctcggatt cccaaggagc atacctccaa   1149

 aatccgagaa gagcaaatca gagtcttcaa aatggatcac cactaagggc atgttcattc   1209

 ttcactttct ttctgctttt acaaaagaac ttggatgtat gttccaaagg gtcctcattc   1269

 tgttcctctt ttgaactttt ccttttgtcc ttgtattaaa gtggttttaa aggggtctaa   1329

 aaagattttg gcaaaacata tttgcagatg tagattagct ggtgaagaaa attactgcta   1389

 gagatcaact gattaactgg taaagaacgt ttattttata acccttgaag aatagaagga   1449

 catagttgga ttattgtgtg tgcattgtat ttttacttct attttttttt tgctttccat   1509

 tttccagtta gcagagataa aatgagagcg ttttaacttc aatgtaccat tttactgagt   1569

 gctaaggaag catatcaatt ccaatatttt ataaccaaag ctctatcaga acatatttat   1629

 aaaacttgtt ggaattttta cggctttggt gtagtcatgt aggtaaatca tttaaaatat   1689

 aaaacaatct caatttagat caagggttat ttcttagatc aaatttatgc caattatatg   1749

 aaaagatttt aactccgaga caggagtctt tcagtgctga atttttagac tgtaaatgag   1809

 ttcttcttaa cttagctgtt tccctacttc tgtgacttct gtgttagcca tcttatttct   1869

 ttaaaatctg agtcctgatt ggcttaatga ttttgcagca gacatgtctc cacatattct   1929

 caaatgctgt catgcggaaa cgtatgaaac agatgaagaa tgactgaccc agattttaga   1989

 tgtataatgt tgttaaagta catactactg taaaaatatg ggatgaattt tatatattaa   2049

 gaaatgccaa aaacatagtt tctgcaccaa gttaattatc cctgtccttt cacatttata   2109

 gggggaaaat aaatacttta tagcctaaca gttatttgat gttattcttg cagagggaat   2169

 ggaaaggaat ggaaagattt gttggcgtaa tttttgaata tttgttatga tcatatgaat   2229

 aagtaaaaaa attcatcctg ctgatggcaa aaaaaaaaaa aaaaa                   2274




      <210> 585
      <211> 276
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(276)

      <400> 585
 tttcttataa tgccaacttt gtacaagaaa gctgggtcgg cgcgcccacc cttcacc        57                                                                 
 atg att ctg ggg tcc ctg gcg ttc tac ctg gtg cag ctc aca ggt tcc      105
 Met Ile Leu Gly Ser Leu Ala Phe Tyr Leu Val Gln Leu Thr Gly Ser
   1               5                  10                  15

 gag aca ggc cag gcc tcc cgt ctc cgc tcc agc ccc cag gct cga cag      153
 Glu Thr Gly Gln Ala Ser Arg Leu Arg Ser Ser Pro Gln Ala Arg Gln
              20                  25                  30

 agt ggg aag gat gaa aca cac tcg gac cct act ggc agg gag gcc tgc      201
 Ser Gly Lys Asp Glu Thr His Ser Asp Pro Thr Gly Arg Glu Ala Cys
          35                  40                  45

 gag gct gac tcc aca tgg gct cac ctt gaa aga agc gag gaa aag acc      249
 Glu Ala Asp Ser Thr Trp Ala His Leu Glu Arg Ser Glu Glu Lys Thr
      50                  55                  60

 acg aat ctg ctt gga cag aag aag tga                                  276
 Thr Asn Leu Leu Gly Gln Lys Lys 
  65                  70





      <210> 586
      <211> 2936
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (329)..(2773)

      <400> 586
 tcccgggtcg acgatttcgt gaaaccggca tttccagctc caggactaca aggccgccac     60

 aaatagctac agccaggccc tgaagctgac caaggacaag gccctgctgg ccacgcttta    120

 tcggaaccgg gcagcctgtg gcctgaaaac ggagagctac gtccaggcag cttcagatgc    180

 ctccagagcc atcgacatca actcctcgga catcaaggct ctgtatcggc gatgccaggc    240

 actggagcac ctggggaagc tggaccaggc cttcaaagac gtgcagcgtt gtgccaccct    300

 cgagccacgg aaccagaact tccaggag   atg ctg agg aga ctc aac acc agc     352
                                  Met Leu Arg Arg Leu Asn Thr Ser
                                    1               5

 att cag gag aag ctc cga gtg cag ttc tcc aca gac tcg agg gta cag      400
 Ile Gln Glu Lys Leu Arg Val Gln Phe Ser Thr Asp Ser Arg Val Gln
      10                  15                  20

 aag atg ttt gag atc ctc ttg gat gaa aac agt gag gct gat aag cgg      448
 Lys Met Phe Glu Ile Leu Leu Asp Glu Asn Ser Glu Ala Asp Lys Arg
  25                  30                  35                  40

 gaa aag gct gcc aac aat ctc att gtc cta ggc cgt gag gaa gca ggg      496
 Glu Lys Ala Ala Asn Asn Leu Ile Val Leu Gly Arg Glu Glu Ala Gly
                  45                  50                  55

 gct gag aag atc ttc cag aac aat gga gta gcc ttg cta ctg cag ctt      544
 Ala Glu Lys Ile Phe Gln Asn Asn Gly Val Ala Leu Leu Leu Gln Leu
              60                  65                  70

 ctg gac act aag aag cct gag ctg gtg ctg gct gca gtg cgg acc ctg      592
 Leu Asp Thr Lys Lys Pro Glu Leu Val Leu Ala Ala Val Arg Thr Leu
          75                  80                  85

 tcg ggc atg tgc agc ggc cac caa gcc aga gcc aca gtg att ctg cat      640
 Ser Gly Met Cys Ser Gly His Gln Ala Arg Ala Thr Val Ile Leu His
      90                  95                 100

 gca gtg cgg ata gac cga atc tgt agc ctc atg gcc gtg gag aat gag      688
 Ala Val Arg Ile Asp Arg Ile Cys Ser Leu Met Ala Val Glu Asn Glu
 105                 110                 115                 120

 gag atg tct ctg gct gtc tgc aac ctg ctc caa gcc atc att gac tcc      736
 Glu Met Ser Leu Ala Val Cys Asn Leu Leu Gln Ala Ile Ile Asp Ser
                 125                 130                 135

 ttg tct ggg gag gac aag cgg gag cat cga ggg aag gag gag gcc ctg      784
 Leu Ser Gly Glu Asp Lys Arg Glu His Arg Gly Lys Glu Glu Ala Leu
             140                 145                 150

 gtt cta gac acc aag aag gac ctg aag cag atc acc agc cac ctg ctg      832
 Val Leu Asp Thr Lys Lys Asp Leu Lys Gln Ile Thr Ser His Leu Leu
         155                 160                 165

 gac atg cta gtc agc aag aag gtg tct ggc cag ggc agg gat cag gcg      880
 Asp Met Leu Val Ser Lys Lys Val Ser Gly Gln Gly Arg Asp Gln Ala
     170                 175                 180

 ctg aac ctg ctc aat aag aat gtt ccc agg aag gac ctt gcc att cat      928
 Leu Asn Leu Leu Asn Lys Asn Val Pro Arg Lys Asp Leu Ala Ile His
 185                 190                 195                 200

 gac aac tca cgt acc atc tat gtg gtg gat aat ggt ctg agg aag atc      976
 Asp Asn Ser Arg Thr Ile Tyr Val Val Asp Asn Gly Leu Arg Lys Ile
                 205                 210                 215

 ctg aag gtt gtg ggg cag gtt cca gat ctg cca tcc tgc ctg ccc ctg     1024
 Leu Lys Val Val Gly Gln Val Pro Asp Leu Pro Ser Cys Leu Pro Leu
             220                 225                 230

 act gac aac acc cgc atg ctg gcc tct atc ctc atc aac aag ctc tat     1072
 Thr Asp Asn Thr Arg Met Leu Ala Ser Ile Leu Ile Asn Lys Leu Tyr
         235                 240                 245

 gat gac ctg cgc tgt gac ccg gag cgc gat cac ttc cgc aag atc tgt     1120
 Asp Asp Leu Arg Cys Asp Pro Glu Arg Asp His Phe Arg Lys Ile Cys
     250                 255                 260

 gag gaa tat atc acg ggc aag ttt gac ccc cag gac atg gac aag aac     1168
 Glu Glu Tyr Ile Thr Gly Lys Phe Asp Pro Gln Asp Met Asp Lys Asn
 265                 270                 275                 280

 ttg aat gcc atc cag aca gtg tca ggg atc ctg cag ggc ccc ttt gac     1216
 Leu Asn Ala Ile Gln Thr Val Ser Gly Ile Leu Gln Gly Pro Phe Asp
                 285                 290                 295

 ctg ggc aac cag ctg ctg gga ctg aaa ggt gtg atg gag atg atg gtg     1264
 Leu Gly Asn Gln Leu Leu Gly Leu Lys Gly Val Met Glu Met Met Val
             300                 305                 310

 gca cta tgt ggc tca gag cgc gag acg gac cag ctg gtg gcc gtg gag     1312
 Ala Leu Cys Gly Ser Glu Arg Glu Thr Asp Gln Leu Val Ala Val Glu
         315                 320                 325

 gcc ctc atc cat gcc tcc acg aag ctc agc cgc gcc acc ttc atc atc     1360
 Ala Leu Ile His Ala Ser Thr Lys Leu Ser Arg Ala Thr Phe Ile Ile
     330                 335                 340

 acc aat gga gtg tca ctg ctc aaa cag atc tac aag acc acc aaa aat     1408
 Thr Asn Gly Val Ser Leu Leu Lys Gln Ile Tyr Lys Thr Thr Lys Asn
 345                 350                 355                 360

 gag aag atc aag atc cgc aca ctg gtg gga ctc tgt aag ctc ggc tct     1456
 Glu Lys Ile Lys Ile Arg Thr Leu Val Gly Leu Cys Lys Leu Gly Ser
                 365                 370                 375

 gca ggt ggc aca gac tac ggt ctc agg cag ttt gcg gaa ggg tcg aca     1504
 Ala Gly Gly Thr Asp Tyr Gly Leu Arg Gln Phe Ala Glu Gly Ser Thr
             380                 385                 390

 gaa aaa ctg gcc aaa cag tgt cgc aag tgg ctg tgc aat atg tcc ata     1552
 Glu Lys Leu Ala Lys Gln Cys Arg Lys Trp Leu Cys Asn Met Ser Ile
         395                 400                 405

 gac act cgg acc cga cgc tgg gca gtg gag ggc ctg gcc tac ctc acg     1600
 Asp Thr Arg Thr Arg Arg Trp Ala Val Glu Gly Leu Ala Tyr Leu Thr
     410                 415                 420

 ctg gac gct gat gtg aag gac gac ttt gtc cag gac gtc cct gcc ctg     1648
 Leu Asp Ala Asp Val Lys Asp Asp Phe Val Gln Asp Val Pro Ala Leu
 425                 430                 435                 440

 cag gcc atg ttt gag ctg gcc aag acc agt gac aag acc atc ctg tac     1696
 Gln Ala Met Phe Glu Leu Ala Lys Thr Ser Asp Lys Thr Ile Leu Tyr
                 445                 450                 455

 tcg gtg gcc acc acc ctg gtg aac tgc acc aac agc tac gat gtc aag     1744
 Ser Val Ala Thr Thr Leu Val Asn Cys Thr Asn Ser Tyr Asp Val Lys
             460                 465                 470

 gag gtc atc cca gag ctt gtc cag ctc gcc aag ttc tcc aag cag cat     1792
 Glu Val Ile Pro Glu Leu Val Gln Leu Ala Lys Phe Ser Lys Gln His
         475                 480                 485

 gtg ccc gag gaa cac ccc aag gac aag aag gac ttt ata gac atg cgg     1840
 Val Pro Glu Glu His Pro Lys Asp Lys Lys Asp Phe Ile Asp Met Arg
     490                 495                 500

 gtg aag cgg ctt ctg aag gcg ggt gtc atc tct gcc ctg gct tgc atg     1888
 Val Lys Arg Leu Leu Lys Ala Gly Val Ile Ser Ala Leu Ala Cys Met
 505                 510                 515                 520

 gtg aaa gca gat agt gcc atc ctc act gac cag acc aag gag ctg ctg     1936
 Val Lys Ala Asp Ser Ala Ile Leu Thr Asp Gln Thr Lys Glu Leu Leu
                 525                 530                 535

 gcc agg gta ttc ctg gca ctg tgt gac aac cca aag gac cga ggc acc     1984
 Ala Arg Val Phe Leu Ala Leu Cys Asp Asn Pro Lys Asp Arg Gly Thr
             540                 545                 550

 att gtg gct caa ggt ggt ggc aag gcc ctg att ccc ctg gct ttg gag     2032
 Ile Val Ala Gln Gly Gly Gly Lys Ala Leu Ile Pro Leu Ala Leu Glu
         555                 560                 565

 ggc aca gat gtg ggc aag gtg aag gca gcc cac gct cta gca aag atc     2080
 Gly Thr Asp Val Gly Lys Val Lys Ala Ala His Ala Leu Ala Lys Ile
     570                 575                 580

 gct gct gtc tcc aat ccg gac att gct ttt cct ggg gag cgg gtg tat     2128
 Ala Ala Val Ser Asn Pro Asp Ile Ala Phe Pro Gly Glu Arg Val Tyr
 585                 590                 595                 600

 gag gtg gtg cgg ccc ctt gta aga ctc ttg gac aca cag agg gat ggg     2176
 Glu Val Val Arg Pro Leu Val Arg Leu Leu Asp Thr Gln Arg Asp Gly
                 605                 610                 615

 ctt cag aac tat gag gct ctc cta ggc ctc acc aac ctg tct ggg cgg     2224
 Leu Gln Asn Tyr Glu Ala Leu Leu Gly Leu Thr Asn Leu Ser Gly Arg
             620                 625                 630

 agt gac aaa ctc cgg cag aag atc ttt aag gag agg gcc ttg cca gac     2272
 Ser Asp Lys Leu Arg Gln Lys Ile Phe Lys Glu Arg Ala Leu Pro Asp
         635                 640                 645

 atc gag aac tac atg ttt gag aat cat gat cag ctg cgg cag gcg gcc     2320
 Ile Glu Asn Tyr Met Phe Glu Asn His Asp Gln Leu Arg Gln Ala Ala
     650                 655                 660

 acc gag tgc atg tgc aac atg gtg ctc cac aag gag gta cag gaa agg     2368
 Thr Glu Cys Met Cys Asn Met Val Leu His Lys Glu Val Gln Glu Arg
 665                 670                 675                 680

 ttc ttg gct gac ggg aat gac cgg ctg aag ctg gtg gtg ctg ctc tgc     2416
 Phe Leu Ala Asp Gly Asn Asp Arg Leu Lys Leu Val Val Leu Leu Cys
                 685                 690                 695

 ggg gag gat gat gat aag gtg cag aat gcg gct gca ggg gct ctg gcc     2464
 Gly Glu Asp Asp Asp Lys Val Gln Asn Ala Ala Ala Gly Ala Leu Ala
             700                 705                 710

 atg ctg aca gca gca cac aag aaa ctg tgc ctc aag atg act caa gtg     2512
 Met Leu Thr Ala Ala His Lys Lys Leu Cys Leu Lys Met Thr Gln Val
         715                 720                 725

 aca acc cag tgg ttg gag atc ctc cag cgg ctt tgc ctg cac gac cag     2560
 Thr Thr Gln Trp Leu Glu Ile Leu Gln Arg Leu Cys Leu His Asp Gln
     730                 735                 740

 ctg tct gtc caa cac cgg ggc ctg gtc att gcc tac aac cta ctg gca     2608
 Leu Ser Val Gln His Arg Gly Leu Val Ile Ala Tyr Asn Leu Leu Ala
 745                 750                 755                 760

 gcc gat gct gag ctg gcc aag aag ctg gtg gag agt gag ctg ctg gag     2656
 Ala Asp Ala Glu Leu Ala Lys Lys Leu Val Glu Ser Glu Leu Leu Glu
                 765                 770                 775

 atc ctg act gtg gtg ggc aaa cag gag cca gat gag aag aag gca gaa     2704
 Ile Leu Thr Val Val Gly Lys Gln Glu Pro Asp Glu Lys Lys Ala Glu
             780                 785                 790

 gtg gtt cag aca gcc cga gaa tgt ctc atc aag tgc atg gat tat ggt     2752
 Val Val Gln Thr Ala Arg Glu Cys Leu Ile Lys Cys Met Asp Tyr Gly
         795                 800                 805

 ttc att aaa cca gtg tct tag ac agcgaccctc agggatgctg ggagtggtcc     2805
 Phe Ile Lys Pro Val Ser 
     810

 tgtactgtgc agagtcctgg gttggttggg ttctcctgga gagtcaggtc atctagggat   2865

 catagcagtg acaatgaagt ctcaatataa aggaaagact tgattgttct ctgagttgtg   2925

 agtcttctcc t                                                        2936




      <210> 587
      <211> 427
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(392)

      <400> 587
 gccggctact cctgctcagc    atg gct gct tta ggg act gtt ctc ttc aca      50
                          Met Ala Ala Leu Gly Thr Val Leu Phe Thr
                            1               5                  10

 ggt gtc cgg agg ctg cac tgc agc gca gcc gct tgg gcg ggc ggc cag       98
 Gly Val Arg Arg Leu His Cys Ser Ala Ala Ala Trp Ala Gly Gly Gln
                  15                  20                  25

 tgg cga cta cag cag gga ctg gct gcc aac ccc tcc ggc tac ggg ccc      146
 Trp Arg Leu Gln Gln Gly Leu Ala Ala Asn Pro Ser Gly Tyr Gly Pro
              30                  35                  40

 ctt acc gag ctc cca gac tgg tca tat gcg gat ggc cgc cct gct ccc      194
 Leu Thr Glu Leu Pro Asp Trp Ser Tyr Ala Asp Gly Arg Pro Ala Pro
          45                  50                  55

 cca atg aaa ggc cag ctt cga aga aaa gct gaa agg gag acg ttt gca      242
 Pro Met Lys Gly Gln Leu Arg Arg Lys Ala Glu Arg Glu Thr Phe Ala
      60                  65                  70

 aga cga gtt gta ctg ctg tca cag gaa atg gac gct gga tta caa gca      290
 Arg Arg Val Val Leu Leu Ser Gln Glu Met Asp Ala Gly Leu Gln Ala
  75                  80                  85                  90

 tgg cag ctc agg cag cag aag ttg cag gaa gaa caa agg aag cag gaa      338
 Trp Gln Leu Arg Gln Gln Lys Leu Gln Glu Glu Gln Arg Lys Gln Glu
                  95                 100                 105

 aat gct ctt aaa ccc aaa ggg gct tca ctg aag agc cca ctt cca agt      386
 Asn Ala Leu Lys Pro Lys Gly Ala Ser Leu Lys Ser Pro Leu Pro Ser
             110                 115                 120

 caa taa aaagcaactc ctgcctccct tcctcaaaaa aaaaa                       427
 Gln 






      <210> 588
      <211> 963
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (482)..(712)

      <400> 588
 gagtgggtgc gagtgagaat gagtggcaaa atgtaatgaa aactttacat gaatgcttat     60

 ttaggttgtt caaagtaaaa agggctacag gtcacagatc gtcagtgcct gagaaagaac    120

 attgacttac tctatatcaa ttgaggggaa agtgcagtac cgtcatcttc aagccttgta    180

 agcataaaag agaataggct gcccatataa gtcaaaggaa aatgagccca ggccttgcta    240

 tgaagcagtg tgtgaatgga caatgttgaa tgaatgtctg gctcagtgat ggagagccag    300

 gttcatcttt gaaatctagg gctcttcact catgaagcag actcctagtc ctggagtgac    360

 tgtgtacgag agcgtggttg tggtgctgta tgtgaacgca tgcaagcttg attcaccttc    420

 agggggctga taacctagta aatcatcaaa atgagatcat aagtgttaat gtacactgga    480

 c    atg aaa aca aag act ggt tta gca gca gac att ggt tta ctc tgc     526
      Met Lys Thr Lys Thr Gly Leu Ala Ala Asp Ile Gly Leu Leu Cys
        1               5                  10                  15

 agc ctg tgt ttt ctg ttt ccc cct ttc cca cct cct tcc ccc cac cca      574
 Ser Leu Cys Phe Leu Phe Pro Pro Phe Pro Pro Pro Ser Pro His Pro
                  20                  25                  30

 atc ctt ttt ttt ttc ttt ttt gct ttt ctt ttc ttt ttt ttt agt ttt      622
 Ile Leu Phe Phe Phe Phe Phe Ala Phe Leu Phe Phe Phe Phe Ser Phe
              35                  40                  45

 tat tta ctt tac cta gta tgc ctt ttt tta gtt gct tct caa gtc aga      670
 Tyr Leu Leu Tyr Leu Val Cys Leu Phe Leu Val Ala Ser Gln Val Arg
          50                  55                  60

 aaa ctt ttc agg aag gtt tcc ctg tgc att tgc acc aga tga atgtttg      719
 Lys Leu Phe Arg Lys Val Ser Leu Cys Ile Cys Thr Arg 
      65                  70                  75

 atgctatgaa aagctttcca tatcatcaaa actaatttgt gtagattttt gcatgaaaaa    779

 aatcataaat ttccctcaaa atagactgtg ttgcagtaca caagttgcca taatagtata    839

 aaacagtaaa atgtgcttaa aaggccatcc ttttcatttt cagagataac ataaagatct    899

 ttgcatgagg taaatctaca gcatagttca tttttagatt ttgttgagtc ctgtaaaaaa    959

 aaaa                                                                 963




      <210> 589
      <211> 1639
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (45)..(1352)

      <400> 589
 gggaaaggtt caagtgcggg ttttctcctt gaacctagaa gatt atg ggt caa gag      56
                                                  Met Gly Gln Glu
                                                    1

 ctg tgt gca aag act gta cag cct gga tgc agc tgc tac cat tgt tca      104
 Leu Cys Ala Lys Thr Val Gln Pro Gly Cys Ser Cys Tyr His Cys Ser
   5                  10                  15                  20

 gag gga ggc gag gca cac agc tgt cgg agg agt cag cct gag acc acg      152
 Glu Gly Gly Glu Ala His Ser Cys Arg Arg Ser Gln Pro Glu Thr Thr
                  25                  30                  35

 gag gct gcg ttc aag cta aca gac cta aaa gaa gca tca tgt tcc atg      200
 Glu Ala Ala Phe Lys Leu Thr Asp Leu Lys Glu Ala Ser Cys Ser Met
              40                  45                  50

 act tca ttt cac ccc agg gga ctt caa gct gcc cgt gcc cag aag ttc      248
 Thr Ser Phe His Pro Arg Gly Leu Gln Ala Ala Arg Ala Gln Lys Phe
          55                  60                  65

 aag agt aaa agg cca cgg agt aac agt gat tgt ttt cag gaa gag gat      296
 Lys Ser Lys Arg Pro Arg Ser Asn Ser Asp Cys Phe Gln Glu Glu Asp
      70                  75                  80

 ctg agg cag ggt ttt cag tgg agg aag agc ctc cct ttt ggg gca gcc      344
 Leu Arg Gln Gly Phe Gln Trp Arg Lys Ser Leu Pro Phe Gly Ala Ala
  85                  90                  95                 100

 tca tct tac ttg aac ttg gag aag ctg ggt gaa ggc tct tat gcg aca      392
 Ser Ser Tyr Leu Asn Leu Glu Lys Leu Gly Glu Gly Ser Tyr Ala Thr
                 105                 110                 115

 gtt tac aag ggg att agc aga ata aat gga caa cta gtg gct tta aaa      440
 Val Tyr Lys Gly Ile Ser Arg Ile Asn Gly Gln Leu Val Ala Leu Lys
             120                 125                 130

 gtc atc agc atg aat gca gag gaa gga gtc cca ttt aca gct atc cga      488
 Val Ile Ser Met Asn Ala Glu Glu Gly Val Pro Phe Thr Ala Ile Arg
         135                 140                 145

 gaa gct tct ctc ctg aag ggt ttg aaa cat gcc aat att gtg ctc ctg      536
 Glu Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn Ile Val Leu Leu
     150                 155                 160

 cat gac ata atc cac acc aaa gag aca ctg aca ttc gtt ttt gaa tac      584
 His Asp Ile Ile His Thr Lys Glu Thr Leu Thr Phe Val Phe Glu Tyr
 165                 170                 175                 180

 atg cac aca gac ctg gcc cag tat atg tct cag cat cca gga ggg ctt      632
 Met His Thr Asp Leu Ala Gln Tyr Met Ser Gln His Pro Gly Gly Leu
                 185                 190                 195

 cat cct cat aat gtc aga ctt ttc atg ttt caa ctt ttg cgg ggc ctg      680
 His Pro His Asn Val Arg Leu Phe Met Phe Gln Leu Leu Arg Gly Leu
             200                 205                 210

 gcg tac atc cac cac caa cac gtt ctt cac agg gac ctg aaa cct cag      728
 Ala Tyr Ile His His Gln His Val Leu His Arg Asp Leu Lys Pro Gln
         215                 220                 225

 aac tta ctc atc agt cac ctg gga gag ctc aaa ctg gct gat ttt ggt      776
 Asn Leu Leu Ile Ser His Leu Gly Glu Leu Lys Leu Ala Asp Phe Gly
     230                 235                 240

 ctt gcc cgg gcc aag tcc att ccc agc cag aca tac tct tca gaa gtc      824
 Leu Ala Arg Ala Lys Ser Ile Pro Ser Gln Thr Tyr Ser Ser Glu Val
 245                 250                 255                 260

 gtg acc ctc tgg tac cgg ccc cct gat gct ttg ctg gga gcc act gaa      872
 Val Thr Leu Trp Tyr Arg Pro Pro Asp Ala Leu Leu Gly Ala Thr Glu
                 265                 270                 275

 tat tcc tct gag ctg gac ata tgg ggt gca ggc tgc atc ttt att gaa      920
 Tyr Ser Ser Glu Leu Asp Ile Trp Gly Ala Gly Cys Ile Phe Ile Glu
             280                 285                 290

 atg ttc cag ggt caa cct ttg ttt cct ggg gtt tcc aac atc ctt gaa      968
 Met Phe Gln Gly Gln Pro Leu Phe Pro Gly Val Ser Asn Ile Leu Glu
         295                 300                 305

 cag ctg gag aaa atc tgg gag gtg ctg gga gtc cct aca gag gat act     1016
 Gln Leu Glu Lys Ile Trp Glu Val Leu Gly Val Pro Thr Glu Asp Thr
     310                 315                 320

 tgg ccg gga gtc tcc aag cta cct aac tac aat cca gaa tgg ttc cca     1064
 Trp Pro Gly Val Ser Lys Leu Pro Asn Tyr Asn Pro Glu Trp Phe Pro
 325                 330                 335                 340

 ctg cct acg cct cga agc ctt cat gtt gtc tgg aac agg ctg ggc agg     1112
 Leu Pro Thr Pro Arg Ser Leu His Val Val Trp Asn Arg Leu Gly Arg
                 345                 350                 355

 gtt cct gaa gct gaa gac ctg gcc tcc cag atg cta aaa ggc ttt ccc     1160
 Val Pro Glu Ala Glu Asp Leu Ala Ser Gln Met Leu Lys Gly Phe Pro
             360                 365                 370

 aga gac cgc gtc tcc gcc cag gaa gca ctt gtt cat gat tat ttc agc     1208
 Arg Asp Arg Val Ser Ala Gln Glu Ala Leu Val His Asp Tyr Phe Ser
         375                 380                 385

 gcc ctg cca tct cag ctg tac cag ctt cct gat gag gag tct ttg ttt     1256
 Ala Leu Pro Ser Gln Leu Tyr Gln Leu Pro Asp Glu Glu Ser Leu Phe
     390                 395                 400

 aca gtt tca gga gtg agg cta aag cca gaa atg tgt gac ctt ttg gcc     1304
 Thr Val Ser Gly Val Arg Leu Lys Pro Glu Met Cys Asp Leu Leu Ala
 405                 410                 415                 420

 tcc tac cag aaa ggt cac cac cca gcc cag ttt agc aaa tgc tgg tga     1352
 Ser Tyr Gln Lys Gly His His Pro Ala Gln Phe Ser Lys Cys Trp 
                 425                 430                 435

 aaagaaaggg cgagatcacc aaggttcttc cagggctgta tttctgcagt ttcggttttc   1412

 atttgcttca gcttactaag aagcttcaaa tctaactcca tactgaacaa ggggctttat   1472

 gtcctcacct atgacctgga atagtttaaa tatggtgttc aaggcaatag tacataatag   1532

 tggaagaaaa ttcagtggaa ggttattgct attgtcattt gcatagaatt taagtgattg   1592

 atttaaaaaa actggacata aactaagtct aagcagaaaa aaaaaaa                 1639




      <210> 590
      <211> 748
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(500)

      <400> 590
 gaggccctga g atg agg ctc caa aga ccc cga cag gcc ccg gcg ggt ggg      50
              Met Arg Leu Gln Arg Pro Arg Gln Ala Pro Ala Gly Gly
                1               5                  10

 agg cgc gcg ccc cgg ggc ggg cgg ggc tcc ccc tac cgg cca gac cca       98
 Arg Arg Ala Pro Arg Gly Gly Arg Gly Ser Pro Tyr Arg Pro Asp Pro
      15                  20                  25

 ggg aga ggc gcg cgg agg ctg cga agg ttc cag aag ggc ggg gag ggg      146
 Gly Arg Gly Ala Arg Arg Leu Arg Arg Phe Gln Lys Gly Gly Glu Gly
  30                  35                  40                  45

 gcg ccg cgc gct gac cct ccc tgg gca ccg ctg ggg acg atg gcg ctg      194
 Ala Pro Arg Ala Asp Pro Pro Trp Ala Pro Leu Gly Thr Met Ala Leu
                  50                  55                  60

 ctc gcc ttg ctg ctg gtc gtg gcc cta ccg cgg gtg tgg aca gac gcc      242
 Leu Ala Leu Leu Leu Val Val Ala Leu Pro Arg Val Trp Thr Asp Ala
              65                  70                  75

 aac ctg act gcg aga caa cga gat cca gag gac tcc cag cgg acg gac      290
 Asn Leu Thr Ala Arg Gln Arg Asp Pro Glu Asp Ser Gln Arg Thr Asp
          80                  85                  90

 gag ggt gac aat aga gtg tgg tgt cat gtt tgt gag aga gaa aac act      338
 Glu Gly Asp Asn Arg Val Trp Cys His Val Cys Glu Arg Glu Asn Thr
      95                 100                 105

 ttc gag tgc cag aac cca agg agg tgc aaa tgg aca gag cca tac tgc      386
 Phe Glu Cys Gln Asn Pro Arg Arg Cys Lys Trp Thr Glu Pro Tyr Cys
 110                 115                 120                 125

 gtt ata gcg gcc gtg atg ctc cgc tgg ttg tgc agc gat gga gag acc      434
 Val Ile Ala Ala Val Met Leu Arg Trp Leu Cys Ser Asp Gly Glu Thr
                 130                 135                 140

 caa gcc aga gga gaa gcg gtt tct cct gga aga gcc cat gcc ctt ctt      482
 Gln Ala Arg Gly Glu Ala Val Ser Pro Gly Arg Ala His Ala Leu Leu
             145                 150                 155

 tta cct caa gtg ttg taa aattcg ctactgcaat ttagaggggc cacctatcaa      536
 Leu Pro Gln Val Leu 
         160

 ctcatcagtg ttcaaagaat atgctgggag catgggtgag agctgtggtg ggctgtggct    596

 ggccatcctc ctgctgctgg cctccattgc agccggcctc agcctgtctt gagccacggg    656

 actgccacag actgagcctt ccggagcatg gactcgctcc agaccgttgt cacctgttgc    716

 attaaacttg ttttctgtta aaaaaaaaaa ac                                  748




      <210> 591
      <211> 2523
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2523)

      <400> 591
  atg ggc tgg agg ccc cgg aga gct cgg ggg acc ccg ttg ctg ctg ctg      48
  Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu
    1               5                  10                  15

 cta cta ctg ctg ctg ctc tgg cca gtg cca ggc gcc ggg gtg ctt caa       96
 Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln
              20                  25                  30

 ggt gag gac gcg ggc ggg gtc ccc ctc acc ctg tgc tct gtc ttt act      144
 Gly Glu Asp Ala Gly Gly Val Pro Leu Thr Leu Cys Ser Val Phe Thr
          35                  40                  45

 cca gga cat atc cct ggg cag cca gtc acc ccg cac tgg gtc ctg gat      192
 Pro Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp
      50                  55                  60

 gga caa ccc tgg cgc acc gtc agc ctg gag gag ccg gtc tcg aag cca      240
 Gly Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro
  65                  70                  75                  80

 gac atg ggg ctg gtg gcc ctg gag gct gaa ggc cag gag ctc ctg ctt      288
 Asp Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu
                  85                  90                  95

 gag ctg gag aag aac cac agg ctg ctg gcc cca gga tac ata gaa acc      336
 Glu Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr
             100                 105                 110

 cac tac ggc cca gat ggg cag cca gtg gtg ctg gcc ccc aac cac acg      384
 His Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr
         115                 120                 125

 gat cat tgc cac tac caa ggg cga gta agg ggc ttc ccc gac tcc tgg      432
 Asp His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp
     130                 135                 140

 gta gtc ctc tgc acc tgc tct ggg atg agt ggc ctg atc acc ctc agc      480
 Val Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser
 145                 150                 155                 160

 agg aat gcc agc tat tat ctg cgt ccc tgg cca ccc cgg ggc tcc aag      528
 Arg Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys
                 165                 170                 175

 gac ttc tca acc cac gag atc ttt cgg atg gag cag ctg ctc acc tgg      576
 Asp Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp
             180                 185                 190

 aaa gga acc tgt ggc cac agg gat cct ggg aac aaa gcg ggc atg acc      624
 Lys Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr
         195                 200                 205

 agc ctt cct ggt ggt ccc cag agc agg ggc agg cga gaa gcg cgc agg      672
 Ser Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg
     210                 215                 220

 acc cgg aag tac ctg gaa ctg tac att gtg gca gac cac acc ctg ttc      720
 Thr Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe
 225                 230                 235                 240

 ttg act cgg cac cga aac ttg aac cac acc aaa cag cgt ctc ctg gaa      768
 Leu Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu
                 245                 250                 255

 gtc gcc aac tac gtg gac cag ctt ctc agg act ctg gac att cag gtg      816
 Val Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val
             260                 265                 270

 gcg ctg acc ggc ctg gag gtg tgg acc gag cgg gac cgc agc cgc gtc      864
 Ala Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val
         275                 280                 285

 acg cag gac gcc aac gcc acg ctc tgg gcc ttc ctg cag tgg cgc cgg      912
 Thr Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg
     290                 295                 300

 ggg ctg tgg gcg cag cgg ccc cac gac tcc gcg cag ctg ctc acg ggc      960
 Gly Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly
 305                 310                 315                 320

 cgc gcc ttc cag ggc gcc aca gtg ggc ctg gcg ccc gtc gag ggc atg     1008
 Arg Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met
                 325                 330                 335

 tgc cgc gcc gag agc tcg gga ggc gtg agc acg gac cac tcg gag ctc     1056
 Cys Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu
             340                 345                 350

 ccc atc ggc gcc gca gcc acc atg gcc cat gag atc ggc cac agc ctc     1104
 Pro Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu
         355                 360                 365

 ggc ctc agc cac gac ccc gac ggc tgc tgc gtg gag gct gcg gcc gag     1152
 Gly Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu
     370                 375                 380

 tcc gga ggc tgc gtc atg gct gcg gcc acc ggg cac ccg ttt ccg cgc     1200
 Ser Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg
 385                 390                 395                 400

 gtg ttc agc gcc tgc agc cgc cgc cag ctg cgc gcc ttc ttc cgc aag     1248
 Val Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys
                 405                 410                 415

 ggg ggc ggc gct tgc ctc tcc aat gcc ccg gac ccc gga ctc ccg gtg     1296
 Gly Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val
             420                 425                 430

 ccg ccg gcg ctc tgc ggg aac ggc ttc gtg gaa gcg ggc gag gag tgt     1344
 Pro Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys
         435                 440                 445

 gac tgc ggc cct ggc cag gag tgc cgc gac ctc tgc tgc ttt gct cac     1392
 Asp Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His
     450                 455                 460

 aac tgc tcg ctg cgc ccg ggg gcc cag tgc gcc cac ggg gac tgc tgc     1440
 Asn Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys
 465                 470                 475                 480

 gtg cgc tgc ctg ctg aag ccg gct gga gcg ctg tgc cgc cag gcc atg     1488
 Val Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met
                 485                 490                 495

 ggt gac tgt gac ctc cct gag ttt tgc acg ggc acc tcc tcc cac tgt     1536
 Gly Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys
             500                 505                 510

 ccc cca gac gtt tac cta ctg gac ggc tca ccc tgt gcc agg ggc agt     1584
 Pro Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser
         515                 520                 525

 ggc tac tgc tgg gat ggc gca tgt ccc acg ctg gag cag cag tgc cag     1632
 Gly Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln
     530                 535                 540

 cag ctc tgg ggg cct ggc tcc cac cca gct ccc gag gcc tgt ttc cag     1680
 Gln Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln
 545                 550                 555                 560

 gtg gtg aac tct gcg gga gat gct cat gga aac tgc ggc cag gac agc     1728
 Val Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser
                 565                 570                 575

 gag ggc cac ttc ctg ccc tgt gca ggg agg gat gcc ctg tgt ggg aag     1776
 Glu Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys
             580                 585                 590

 ctg cag tgc cag ggt gga aag ccc agc ctg ctc gca ccg cac atg gtg     1824
 Leu Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val
         595                 600                 605

 cca gtg gac tct acc gtt cac cta gat ggc cag gaa gtg act tgt cgg     1872
 Pro Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg
     610                 615                 620

 gga gcc ttg gca ctc ccc agt gcc cag ctg gac ctg ctt ggc ctg ggc     1920
 Gly Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly
 625                 630                 635                 640

 ctg gta gag cca ggc acc cag tgt gga cct aga atg gtg tgc cag agc     1968
 Leu Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Gln Ser
                 645                 650                 655

 agg cgc tgc agg aag aat gcc ttc cag gag ctt cag cgc tgc ctg act     2016
 Arg Arg Cys Arg Lys Asn Ala Phe Gln Glu Leu Gln Arg Cys Leu Thr
             660                 665                 670

 gcc tgc cac agc cac ggg gtt tgc aat agc aac cat aac tgc cac tgt     2064
 Ala Cys His Ser His Gly Val Cys Asn Ser Asn His Asn Cys His Cys
         675                 680                 685

 gct cca ggc tgg gct cca ccc ttc tgt gac aag cca ggc ttt ggt ggc     2112
 Ala Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys Pro Gly Phe Gly Gly
     690                 695                 700

 agc atg gac agt ggc cct gtg cag gct gaa aac cat gac acc ttc ctg     2160
 Ser Met Asp Ser Gly Pro Val Gln Ala Glu Asn His Asp Thr Phe Leu
 705                 710                 715                 720

 ctg gcc atg ctc ctc agc gtc ctg ctg cct ctg ctc cca ggg gcc ggc     2208
 Leu Ala Met Leu Leu Ser Val Leu Leu Pro Leu Leu Pro Gly Ala Gly
                 725                 730                 735

 ctg gcc tgg tgt tgc tac cga ctc cca gga gcc cat ctg cag cga tgc     2256
 Leu Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala His Leu Gln Arg Cys
             740                 745                 750

 agc tgg ggc tgc aga agg gac cct gcg tgc agt ggc ccc aaa gat ggc     2304
 Ser Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser Gly Pro Lys Asp Gly
         755                 760                 765

 cca cac agg gac cac ccc ctg ggc ggc gtt cac ccc atg gag ttg ggc     2352
 Pro His Arg Asp His Pro Leu Gly Gly Val His Pro Met Glu Leu Gly
     770                 775                 780

 ccc aca gcc act gga cag ccc tgg ccc ctg gcc cca ggg tct cct gct     2400
 Pro Thr Ala Thr Gly Gln Pro Trp Pro Leu Ala Pro Gly Ser Pro Ala
 785                 790                 795                 800

 gac cat att cac aac att tac cct cca cca ttt ctc cca gac cct gag     2448
 Asp His Ile His Asn Ile Tyr Pro Pro Pro Phe Leu Pro Asp Pro Glu
                 805                 810                 815

 aac tct cat gag ccc agc agc cac cct gag aag cct ctg cca gca gtc     2496
 Asn Ser His Glu Pro Ser Ser His Pro Glu Lys Pro Leu Pro Ala Val
             820                 825                 830

 tcg cct gac ccc caa ggt ggt tcc tga                                 2523
 Ser Pro Asp Pro Gln Gly Gly Ser 
         835                 840





      <210> 592
      <211> 2249
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (23)..(1600)

      <400> 592
 agaccgggag gggacctgga tc atg gct gcc gcg ccg ccg cta cgg gac cgc      52
                          Met Ala Ala Ala Pro Pro Leu Arg Asp Arg
                            1               5                  10

 ctg agc ttt cta cac cgg ctc ccg att ctc ctg aag ggg acg tcc gat      100
 Leu Ser Phe Leu His Arg Leu Pro Ile Leu Leu Lys Gly Thr Ser Asp
                  15                  20                  25

 gat gat gtc ccg tgt ccg ggc tac ctg ttt gaa gag att gct aaa atc      148
 Asp Asp Val Pro Cys Pro Gly Tyr Leu Phe Glu Glu Ile Ala Lys Ile
              30                  35                  40

 tcc cac gag tct ccg ggc agc agc cag tgc ctg ctg gag tac ctc ctg      196
 Ser His Glu Ser Pro Gly Ser Ser Gln Cys Leu Leu Glu Tyr Leu Leu
          45                  50                  55

 agc cgc ctg cac agc agc tcc ggc cac ggg aag ctc aag gtg ctg aag      244
 Ser Arg Leu His Ser Ser Ser Gly His Gly Lys Leu Lys Val Leu Lys
      60                  65                  70

 atc ctg ctc tat ctg tgc agc cac ggc tcc tcc ttc ttc ctg ctc atc      292
 Ile Leu Leu Tyr Leu Cys Ser His Gly Ser Ser Phe Phe Leu Leu Ile
  75                  80                  85                  90

 ctc aaa cgc aac tct gcc ttc atc cag gaa gct gca gct ttt gca ggg      340
 Leu Lys Arg Asn Ser Ala Phe Ile Gln Glu Ala Ala Ala Phe Ala Gly
                  95                 100                 105

 ccc cca gat cct ctg cac ggg aac agc ttg tac cag aag gtt cgc gcg      388
 Pro Pro Asp Pro Leu His Gly Asn Ser Leu Tyr Gln Lys Val Arg Ala
             110                 115                 120

 gcc gcg cag gac ttg ggg agc acc ctg ttc tcg gac acc gtg ttg ccg      436
 Ala Ala Gln Asp Leu Gly Ser Thr Leu Phe Ser Asp Thr Val Leu Pro
         125                 130                 135

 ctg gct ccc tcc cag cct ctg ggg acc ccg cct gcc aca ggc atg ggc      484
 Leu Ala Pro Ser Gln Pro Leu Gly Thr Pro Pro Ala Thr Gly Met Gly
     140                 145                 150

 tcc cag gcc agg ccg cac agc acc ctc cag ggt ttc ggc tac agc aag      532
 Ser Gln Ala Arg Pro His Ser Thr Leu Gln Gly Phe Gly Tyr Ser Lys
 155                 160                 165                 170

 gaa cac ggc cgc acg gct gtg agg cat cag cct ggg cag gcc gga ggg      580
 Glu His Gly Arg Thr Ala Val Arg His Gln Pro Gly Gln Ala Gly Gly
                 175                 180                 185

 ggc tgg gat gag ctg gac agc ggc ccc agc tct cag aat tcc tcc cag      628
 Gly Trp Asp Glu Leu Asp Ser Gly Pro Ser Ser Gln Asn Ser Ser Gln
             190                 195                 200

 aac agt gac ctg agc agg gtc tcg gac tcg ggc agt cat tcc ggc agc      676
 Asn Ser Asp Leu Ser Arg Val Ser Asp Ser Gly Ser His Ser Gly Ser
         205                 210                 215

 gac agc cat tca ggg gcc agc cgg gag ccg ggt gac ctg gca gaa agg      724
 Asp Ser His Ser Gly Ala Ser Arg Glu Pro Gly Asp Leu Ala Glu Arg
     220                 225                 230

 gtc gag gtg gtg gcc ctg agt gac tgt cag cag gag ttg agc ttg gtg      772
 Val Glu Val Val Ala Leu Ser Asp Cys Gln Gln Glu Leu Ser Leu Val
 235                 240                 245                 250

 agg act gtg act cgg gga cca cgc gcc ttc ctg agc cgc gag gag gca      820
 Arg Thr Val Thr Arg Gly Pro Arg Ala Phe Leu Ser Arg Glu Glu Ala
                 255                 260                 265

 cag cac ttc atc aaa gcg tgt gga ctg ctc aac tgt gag gcc gtg ctg      868
 Gln His Phe Ile Lys Ala Cys Gly Leu Leu Asn Cys Glu Ala Val Leu
             270                 275                 280

 cag ctg ctg acc tgc cac ctg cgt ggg acc agt gaa tgc acg cag ctg      916
 Gln Leu Leu Thr Cys His Leu Arg Gly Thr Ser Glu Cys Thr Gln Leu
         285                 290                 295

 agg gcg ctg tgt gcc atc gcc tcc ctg ggg agc agc gac ctc ctc ccc      964
 Arg Ala Leu Cys Ala Ile Ala Ser Leu Gly Ser Ser Asp Leu Leu Pro
     300                 305                 310

 cag gag cac atc ctc ctc cgc acc cgg ccg tgg ctg cag gag ctc agc     1012
 Gln Glu His Ile Leu Leu Arg Thr Arg Pro Trp Leu Gln Glu Leu Ser
 315                 320                 325                 330

 atg ggc agc ccg gga cct gtg acc aac aag gcc acc aag atc ctg agg     1060
 Met Gly Ser Pro Gly Pro Val Thr Asn Lys Ala Thr Lys Ile Leu Arg
                 335                 340                 345

 cac ttt gag gcc tcc tgt ggg cag ctg tcc cct gcc cgg ggc acc tca     1108
 His Phe Glu Ala Ser Cys Gly Gln Leu Ser Pro Ala Arg Gly Thr Ser
             350                 355                 360

 gct gag cct ggc ccc aca gcc gcc ctc cca ggc cca tct gac ctg ctg     1156
 Ala Glu Pro Gly Pro Thr Ala Ala Leu Pro Gly Pro Ser Asp Leu Leu
         365                 370                 375

 acc gac gct gtg cct ctc cct ggg agc cag gtc ttc ctg cag cct ctg     1204
 Thr Asp Ala Val Pro Leu Pro Gly Ser Gln Val Phe Leu Gln Pro Leu
     380                 385                 390

 agt tca acc ccg gtc tcg tcc cgg agc cct gct ccc tca tct ggg atg     1252
 Ser Ser Thr Pro Val Ser Ser Arg Ser Pro Ala Pro Ser Ser Gly Met
 395                 400                 405                 410

 ccg tcc agc cct gtg ccc acc cca ccc cca gat gcc tcc ccc att cca     1300
 Pro Ser Ser Pro Val Pro Thr Pro Pro Pro Asp Ala Ser Pro Ile Pro
                 415                 420                 425

 gcc ccc gga gac ccc agc gag gcc gag gcc aga ctg gca gaa agc agg     1348
 Ala Pro Gly Asp Pro Ser Glu Ala Glu Ala Arg Leu Ala Glu Ser Arg
             430                 435                 440

 cgg tgg aga cct gaa cgg atc ccg ggg ggc acg gac agc cca aag aga     1396
 Arg Trp Arg Pro Glu Arg Ile Pro Gly Gly Thr Asp Ser Pro Lys Arg
         445                 450                 455

 ggc ccc agc agc tgt gcg tgg agc cgc gac tcc ttg ttt gct ggc atg     1444
 Gly Pro Ser Ser Cys Ala Trp Ser Arg Asp Ser Leu Phe Ala Gly Met
     460                 465                 470

 gag ctg gtg gcc tgt ccc cgc ctg gtg ggg gct ggg gct gct gcg gga     1492
 Glu Leu Val Ala Cys Pro Arg Leu Val Gly Ala Gly Ala Ala Ala Gly
 475                 480                 485                 490

 gag tcc tgt cct gat gct ccc cgc gcc ccc caa aca tcg tcc cag agg     1540
 Glu Ser Cys Pro Asp Ala Pro Arg Ala Pro Gln Thr Ser Ser Gln Arg
                 495                 500                 505

 aca gca gcc aaa gag cct cct ggc tca gag ccg tca gct ttc gcg ttc     1588
 Thr Ala Ala Lys Glu Pro Pro Gly Ser Glu Pro Ser Ala Phe Ala Phe
             510                 515                 520

 ctg aac gcc tga ccc gatggcctgg ccctggagtc ttcagcttca gctgctgtct     1643
 Leu Asn Ala 
         525

 ggggcggtct gtgcttcctg agcagcctca accgtagctg ctacagtctc caggcagctt   1703

 gacttgagag gacgacccta gggctacctc agtttccccc atctcctctg ccagaggctc   1763

 tggctatttg gacttgaatc cctacgaggg atggcaggtg gcagggcttc agaaatgtcg   1823

 atctcagggc tctcaggggg cagtccctgc ctgtcttgcc ctcagacatg aggtttcttg   1883

 tatgaatgcg gaagcgacta ccaggttcct tatttcattt tgatctcagc tccctccttc   1943

 cccaggaggt catgagcagc aacaagccac tgctcccccg tcccatcggg gtgggctagg   2003

 tgctgaggct gggtttggtg catgtgggtt gagggtgtct tgtccgggct gccttgtgct   2063

 gtctggcctg aggccatttc aagtctcaga tccctacgtg atccttccct ggctctcacc   2123

 tgctccttta ggctgtaatt gcttcctaca cacgaagcct ctgattggag cctctggtcc   2183

 atctcagaaa aaccttccaa gagcgctggg gtttatgctt tctgaataaa cactactgtt   2243

 tacatg                                                              2249




      <210> 593
      <211> 3662
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(1704)

      <400> 593
 agacgcgtag gctggcagcc cgctgagccc gccagactcc gccgccgtcg ggagccggcc     60

 gctgggagcc cgtcgctatg ggaccgcgct gagccgcccg ctggcggggg agcagcgcgg    120

 tcgagg   atg gag ggg ccg gca gag tgg ggc ccc gag gcg gcg ctg ggc     168
          Met Glu Gly Pro Ala Glu Trp Gly Pro Glu Ala Ala Leu Gly
            1               5                  10

 ccc gag gcg gtg ctg cgc ttc ctg gcg gag cgc ggg ggc cgg gcc ctg      216
 Pro Glu Ala Val Leu Arg Phe Leu Ala Glu Arg Gly Gly Arg Ala Leu
  15                  20                  25                  30

 cac gcc gag ctg gtg cag cac ttc agg ggc gcc cta ggc ggc gaa ccg      264
 His Ala Glu Leu Val Gln His Phe Arg Gly Ala Leu Gly Gly Glu Pro
                  35                  40                  45

 gag cag cgc gcc cgc gcc cgc gcg cac ttc aag gag ctg gtg aac gcc      312
 Glu Gln Arg Ala Arg Ala Arg Ala His Phe Lys Glu Leu Val Asn Ala
              50                  55                  60

 gtg gcc act gtg cgc gtc gat ccc gcc gac ggc gcc aag tac gtg cac      360
 Val Ala Thr Val Arg Val Asp Pro Ala Asp Gly Ala Lys Tyr Val His
          65                  70                  75

 ctc aag aag agg ttc tgt gaa ggg ccg tcc gag ccc tcc ggg gac ccg      408
 Leu Lys Lys Arg Phe Cys Glu Gly Pro Ser Glu Pro Ser Gly Asp Pro
      80                  85                  90

 ccg cga atc cag gtg acc gcc gag ccc gag gcc ccc gac ggc cct gcc      456
 Pro Arg Ile Gln Val Thr Ala Glu Pro Glu Ala Pro Asp Gly Pro Ala
  95                 100                 105                 110

 ggg ccc gag gcg cgc gat cgg ctc ccc gac gcg gcg gcc ccg gag tcg      504
 Gly Pro Glu Ala Arg Asp Arg Leu Pro Asp Ala Ala Ala Pro Glu Ser
                 115                 120                 125

 ctc cct gga cag ggc cgc gag ctg ggc gag gga gag ccc ccc gcc ccc      552
 Leu Pro Gly Gln Gly Arg Glu Leu Gly Glu Gly Glu Pro Pro Ala Pro
             130                 135                 140

 gcg cac tgg ccg ccc ctg agc gcc ggg gct cgc agg aag aac tcg cgg      600
 Ala His Trp Pro Pro Leu Ser Ala Gly Ala Arg Arg Lys Asn Ser Arg
         145                 150                 155

 cgc gac gtg cag ccc cta ccg cgg act cca gcc ccg ggg ccc agc gag      648
 Arg Asp Val Gln Pro Leu Pro Arg Thr Pro Ala Pro Gly Pro Ser Glu
     160                 165                 170

 gac ctg gag ctc ccg cca cat ggc tgc gag gag gcg gac agg ggc agc      696
 Asp Leu Glu Leu Pro Pro His Gly Cys Glu Glu Ala Asp Arg Gly Ser
 175                 180                 185                 190

 tcc ctt gtg ggg gct acc gca cag agg ccg gcc cgc cag aac ctc cgt      744
 Ser Leu Val Gly Ala Thr Ala Gln Arg Pro Ala Arg Gln Asn Leu Arg
                 195                 200                 205

 gac ctg gtg atg ggc agc tcc ccg cag ctg aag agg agc gtg tgt ccc      792
 Asp Leu Val Met Gly Ser Ser Pro Gln Leu Lys Arg Ser Val Cys Pro
             210                 215                 220

 ggg ggc agc agc ccg ggc agc tcc tcc ggg gga gga cgc ggc aga ggc      840
 Gly Gly Ser Ser Pro Gly Ser Ser Ser Gly Gly Gly Arg Gly Arg Gly
         225                 230                 235

 ggg ggc gac tca gac agc gca tcg gtg gcc tcg tcg tcc gcg gag gag      888
 Gly Gly Asp Ser Asp Ser Ala Ser Val Ala Ser Ser Ser Ala Glu Glu
     240                 245                 250

 gag agc agc ggc gga ggc tcc gtg acg ctg gac ccc ctg gag cac gcg      936
 Glu Ser Ser Gly Gly Gly Ser Val Thr Leu Asp Pro Leu Glu His Ala
 255                 260                 265                 270

 tgg atg ctc tct gcc tcc gat ggc aag tgg gac agc ctg gag ggc ttg      984
 Trp Met Leu Ser Ala Ser Asp Gly Lys Trp Asp Ser Leu Glu Gly Leu
                 275                 280                 285

 ctc acc tgc gag ccc ggc ctg ctg gtc aag cgg gac ttc att acc ggc     1032
 Leu Thr Cys Glu Pro Gly Leu Leu Val Lys Arg Asp Phe Ile Thr Gly
             290                 295                 300

 ttc act tgc ctg cac tgg gcc gcc aag cac ggc agg cag gag ctt ctg     1080
 Phe Thr Cys Leu His Trp Ala Ala Lys His Gly Arg Gln Glu Leu Leu
         305                 310                 315

 gcc atg cta gtc aac ttc gcc aac aaa cac cag ctg ccg gtg aac atc     1128
 Ala Met Leu Val Asn Phe Ala Asn Lys His Gln Leu Pro Val Asn Ile
     320                 325                 330

 gac gcc agg acg agc ggg ggt tac acc gcc ctg cac ttg gca gcc atg     1176
 Asp Ala Arg Thr Ser Gly Gly Tyr Thr Ala Leu His Leu Ala Ala Met
 335                 340                 345                 350

 cac ggc cac gtg gag gtg gtg aag ctg ctg gtg ggg gcc tac gac gcc     1224
 His Gly His Val Glu Val Val Lys Leu Leu Val Gly Ala Tyr Asp Ala
                 355                 360                 365

 gat gtg gac atc agg gac tac agt ggg aaa aag gcc tcc cag tac ctg     1272
 Asp Val Asp Ile Arg Asp Tyr Ser Gly Lys Lys Ala Ser Gln Tyr Leu
             370                 375                 380

 agt cgg agc atc gcc gag gag atc aag aac ctg gtg gga gcc ctg gac     1320
 Ser Arg Ser Ile Ala Glu Glu Ile Lys Asn Leu Val Gly Ala Leu Asp
         385                 390                 395

 gag ggt gac ggg gaa agc gcc gcg ggt agc ggc ggc ggg cgc tgg agg     1368
 Glu Gly Asp Gly Glu Ser Ala Ala Gly Ser Gly Gly Gly Arg Trp Arg
     400                 405                 410

 ctt tca aag gtg ctt ccc tcg cat ctc atc acc tac aaa ctc tca cac     1416
 Leu Ser Lys Val Leu Pro Ser His Leu Ile Thr Tyr Lys Leu Ser His
 415                 420                 425                 430

 gcc cta gaa gat gga ggg gac cat cac cac cat cac cac tcg gct gag     1464
 Ala Leu Glu Asp Gly Gly Asp His His His His His His Ser Ala Glu
                 435                 440                 445

 ggg tgg gtc gga ggc aaa gcc aag gat cca ggg cgc aaa gcc tcg ggc     1512
 Gly Trp Val Gly Gly Lys Ala Lys Asp Pro Gly Arg Lys Ala Ser Gly
             450                 455                 460

 agc tct agt gga cgt ata aaa ccc aga ctc aac aaa atc cga ttc aga     1560
 Ser Ser Ser Gly Arg Ile Lys Pro Arg Leu Asn Lys Ile Arg Phe Arg
         465                 470                 475

 acc cag atc gtc cac acc aca ccc tct ttc agg gac cca gag cag ccg     1608
 Thr Gln Ile Val His Thr Thr Pro Ser Phe Arg Asp Pro Glu Gln Pro
     480                 485                 490

 ctg gag ggc agg ggg gag gag gga gtg ggg gag gaa cga cct gtt aaa     1656
 Leu Glu Gly Arg Gly Glu Glu Gly Val Gly Glu Glu Arg Pro Val Lys
 495                 500                 505                 510

 ggc cac tcg ccc ttc aca ttg aga cca aag tcc aat gta ttt ggg taa     1704
 Gly His Ser Pro Phe Thr Leu Arg Pro Lys Ser Asn Val Phe Gly 
                 515                 520                 525

 aaattgcttc ttttagaaaa tgcaaaggtt tatttgtctt aataaattga atactaggtg   1764

 ttgtaaggaa gtgagaccag aaggacaagc taaattatgc attcttactt gagggatcgg   1824

 aatggatggg gcggagttct cttcaggcta gccttctggg aaaagtggat gtctttttca   1884

 gagattcatc ataccttgac ctgtacctct tctctgccct ccacttccct gccctggagt   1944

 ccgtttctgg agactagaaa tgtatctaaa ttgggggaac agaatgaatg aattaatgaa   2004

 tgagagttcc tttgctttaa ccattcctgg atgcctgcaa agtaaggaat aatgcagttt   2064

 ttatgtatct gattttataa ggggttactc tttcaagagt aacaaaaaaa tgcaaactgt   2124

 aatgaaacta cattgtattt ctaagtgtga aaacgacagg ctgccccgtt tttactaatt   2184

 gcatttgcat tttaaggtac tactgaaggt cagatcaaag ttgaaatgca aaaatactaa   2244

 ttagagaata atgtgaataa aatgggaatc ttcttggtat tttatgtgta ttgtaagtag   2304

 cagttaaatt atttttttaa aagcaatttc agttttaatc actgaacaaa agaaacaggc   2364

 aacattcact tctgtagtat ggtttccacc tatctctaac accactatta aggtacacca   2424

 gtgttaaggt acattaataa ctacacaaaa ttttatttaa agagaacact tagcagccta   2484

 tgatagtttt caataaaatg ttgcctctct ttcggattct cactaacttt tgttactatt   2544

 ctaaaagttt gaatttgctg gggtgtttat tctgaggatt atttaaccat tgttctattt   2604

 ggcataaccc tatttaatgg tgcttagagc tgaattacct acagaaactg tttctggttt   2664

 aaataattag cacaaattgg cctaagtatt catgagccca tgtttctgtg aagtaattat   2724

 taaaccaact taatgattct tatgtaaggt acacttttta ttttaataca ttggtagtct   2784

 ctatgacttg tagcaatgtt ttacaaatgt ttaaaatgct aaacttaatt ttccaagctt   2844

 ttcttgacaa ttagatacct atcctgtagt tactgaaaat ctgggtagta aatctaccca   2904

 attaaaatgg cactttataa aagggaatag agaagagatg ggactatttc tatatttaaa   2964

 tgctgctggc tattcctttg tatataaatg aaaaatacca ttcattaaaa ttaagtactc   3024

 gtttaagtat ggttcttaat tacatttcat tcatttatat tagagtaaat ggcttcataa   3084

 ctactttaaa atttaaccca caagcatatt aaatctgttt gttataaggt tggaaacaat   3144

 ttttgagagg gactaattta aacaagtcct cctttagtct tttgggtcgc gtagttgctg   3204

 aaacctaagt acctgcagcc tacaggataa ggaagttcac agcctgcggg gtgaatgaac   3264

 ccatgtgtga actgcacaga gcaattcata gaaaatgcat agaaatttgt aacactttgg   3324

 tcacatctgt ctctagatgg tcattgaatt tgtttaaaga tggatgaaag gccaggcatg   3384

 gtggctcatg cctgtaatcc cagcactttg ggaggccgag gcaggtggat cacttgaggc   3444

 caggagtttg aaaccagcct ggccaacatg gtgaaaacct gtctctacta aaaatacaaa   3504

 aattagccga gcgtggtggt gcgtgcctgt agtcccagct acttaggagg ctgaggcatg   3564

 agaatcactt aaacctgaga ggtggaggtt gcagttgagc caagatcacg acactgcact   3624

 ccagcctggg caacggagac tctgtctcaa aaaaaaaa                           3662




      <210> 594
      <211> 2167
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (222)..(2096)

      <400> 594
 ggggtgggta ggctgggacc tgtgtctgat tagctgggag ggggaagcca tggtcccaac     60

 cgctgtctgc tgagctccag tccgtccagg ctcttccagg aggaagaggc acgatacaag    120

 agaggagggg caggggtccc agcactgaac accctggccg gggttttgac agctgccaca    180

 gtctctgagc tccagcctcg cgcctgaacc cggtccctgc c    atg ggg ccc cct     233
                                                  Met Gly Pro Pro
                                                    1

 tcc agc tca ggc ttc tat gtg agc cgc gca gtg gcc ctg ctg ctg gct      281
 Ser Ser Ser Gly Phe Tyr Val Ser Arg Ala Val Ala Leu Leu Leu Ala
   5                  10                  15                  20

 ggg ttg gta gcc gcc ctc ctg ctg gcg ctg gcc gta ctc gcc gcc ttg      329
 Gly Leu Val Ala Ala Leu Leu Leu Ala Leu Ala Val Leu Ala Ala Leu
                  25                  30                  35

 tac ggc cac tgc gag cgc gtc cca ccg tcg gag ctg cct gga ctc agg      377
 Tyr Gly His Cys Glu Arg Val Pro Pro Ser Glu Leu Pro Gly Leu Arg
              40                  45                  50

 gac tcg gaa gcc gag tct tcc cct ccc ctc agg cag aag ccg acg ccg      425
 Asp Ser Glu Ala Glu Ser Ser Pro Pro Leu Arg Gln Lys Pro Thr Pro
          55                  60                  65

 acc ccg aaa ccc agc agt gca cgc gag cta gcg gtg acg acc acc ccg      473
 Thr Pro Lys Pro Ser Ser Ala Arg Glu Leu Ala Val Thr Thr Thr Pro
      70                  75                  80

 agc aac tgg cga ccc ccg ggg ccc tgg gac cag cta cgc ctg ccg ccc      521
 Ser Asn Trp Arg Pro Pro Gly Pro Trp Asp Gln Leu Arg Leu Pro Pro
  85                  90                  95                 100

 tgg ctc gtg ccg ctg cac tac gat ctg gag ctg tgg ccg cag ctg agg      569
 Trp Leu Val Pro Leu His Tyr Asp Leu Glu Leu Trp Pro Gln Leu Arg
                 105                 110                 115

 ccc gac gag ctt ccg gcc ggg tct ttg ccc ttc act ggc cgc gtg aac      617
 Pro Asp Glu Leu Pro Ala Gly Ser Leu Pro Phe Thr Gly Arg Val Asn
             120                 125                 130

 atc acg gtg cgc tgc acg gtg gcc acc tct cga ctg ctg ctg cat agc      665
 Ile Thr Val Arg Cys Thr Val Ala Thr Ser Arg Leu Leu Leu His Ser
         135                 140                 145

 ctc ttc cag gac tgc gag cgc gcc gag gtg cgg gga ccc ctt tcc ccg      713
 Leu Phe Gln Asp Cys Glu Arg Ala Glu Val Arg Gly Pro Leu Ser Pro
     150                 155                 160

 ggc act ggg aac gcc aca gtg ggc cgc gtg ccc gtg gac gac gtg tgg      761
 Gly Thr Gly Asn Ala Thr Val Gly Arg Val Pro Val Asp Asp Val Trp
 165                 170                 175                 180

 ttc gcg ctg gac acg gaa tac atg gtg ctg gag ctc agt gag ccc ctg      809
 Phe Ala Leu Asp Thr Glu Tyr Met Val Leu Glu Leu Ser Glu Pro Leu
                 185                 190                 195

 aaa cct ggt agc agc tac gag ctg cag ctt agc ttc tcg ggc ctg gtg      857
 Lys Pro Gly Ser Ser Tyr Glu Leu Gln Leu Ser Phe Ser Gly Leu Val
             200                 205                 210

 aag gaa gac ctc agg gag gga ctc ttt ctc aac gtc tac acc gac cag      905
 Lys Glu Asp Leu Arg Glu Gly Leu Phe Leu Asn Val Tyr Thr Asp Gln
         215                 220                 225

 ggc gag cgc agg gcc ctg tta gcg tcc cag ctg gaa cca aca ttt gct      953
 Gly Glu Arg Arg Ala Leu Leu Ala Ser Gln Leu Glu Pro Thr Phe Ala
     230                 235                 240

 agg tat gtt ttc cct tgt ttt gat gag cca gct ctg aag gca act ttt     1001
 Arg Tyr Val Phe Pro Cys Phe Asp Glu Pro Ala Leu Lys Ala Thr Phe
 245                 250                 255                 260

 aat att aca atg att cat cat cca agt tat gtg gcc ctt tcc aac atg     1049
 Asn Ile Thr Met Ile His His Pro Ser Tyr Val Ala Leu Ser Asn Met
                 265                 270                 275

 cca aag cta ggt cag tct gaa aaa gaa gat gtg aat gga agc aaa tgg     1097
 Pro Lys Leu Gly Gln Ser Glu Lys Glu Asp Val Asn Gly Ser Lys Trp
             280                 285                 290

 act gtt aca acc ttt tcc act acg ccc cac atg cca act tac tta gtc     1145
 Thr Val Thr Thr Phe Ser Thr Thr Pro His Met Pro Thr Tyr Leu Val
         295                 300                 305

 gca ttt gtt ata tgt gac tat gac cac gtc aac aga aca gaa agg ggc     1193
 Ala Phe Val Ile Cys Asp Tyr Asp His Val Asn Arg Thr Glu Arg Gly
     310                 315                 320

 aag gag ata cgc atc tgg gcc cgg aaa gat gca att gca aat gga agt     1241
 Lys Glu Ile Arg Ile Trp Ala Arg Lys Asp Ala Ile Ala Asn Gly Ser
 325                 330                 335                 340

 gca gac ttt gct ttg aac atc aca ggt ccc atc ttc tct ttt ctg gag     1289
 Ala Asp Phe Ala Leu Asn Ile Thr Gly Pro Ile Phe Ser Phe Leu Glu
                 345                 350                 355

 gat ttg ttt aat atc agt tac tct ctt cca aaa aca gat ata att gcc     1337
 Asp Leu Phe Asn Ile Ser Tyr Ser Leu Pro Lys Thr Asp Ile Ile Ala
             360                 365                 370

 ttg cct agt ttt gac aac cat gca atg gaa aac tgg gga cta atg ata     1385
 Leu Pro Ser Phe Asp Asn His Ala Met Glu Asn Trp Gly Leu Met Ile
         375                 380                 385

 ttt gat gaa tca gga ttg tcg tcg gaa cca aaa gat caa ctg aca gaa     1433
 Phe Asp Glu Ser Gly Leu Ser Ser Glu Pro Lys Asp Gln Leu Thr Glu
     390                 395                 400

 aaa aag act ctg atc tcc tat gtt gtc tcc cac gag att gga cac cag     1481
 Lys Lys Thr Leu Ile Ser Tyr Val Val Ser His Glu Ile Gly His Gln
 405                 410                 415                 420

 tgg ttt gga aac ttg gtt acc atg aat cgg tgg aac aat atc tgg ctc     1529
 Trp Phe Gly Asn Leu Val Thr Met Asn Arg Trp Asn Asn Ile Trp Leu
                 425                 430                 435

 aac gag ggt ttg cat ctt att ctt gag ttt gaa gta att aac tac ttt     1577
 Asn Glu Gly Leu His Leu Ile Leu Glu Phe Glu Val Ile Asn Tyr Phe
             440                 445                 450

 aat cct aaa ctc cca aga aat gag atc ttt ttt tct aac att tta cat     1625
 Asn Pro Lys Leu Pro Arg Asn Glu Ile Phe Phe Ser Asn Ile Leu His
         455                 460                 465

 aat atc ctc aga gaa gat cac gcc ctg gtg act aga gct gtg gcc atg     1673
 Asn Ile Leu Arg Glu Asp His Ala Leu Val Thr Arg Ala Val Ala Met
     470                 475                 480

 aag gtg gaa aat ttc aaa aca agt gaa ata cag gaa ctc ttt gac ata     1721
 Lys Val Glu Asn Phe Lys Thr Ser Glu Ile Gln Glu Leu Phe Asp Ile
 485                 490                 495                 500

 ttt act tac agc aag gga gcg tct atg gcc cgg atg ctt tct tgt ttc     1769
 Phe Thr Tyr Ser Lys Gly Ala Ser Met Ala Arg Met Leu Ser Cys Phe
                 505                 510                 515

 ttg aat gag cat tta ttt gtc agt gca ctc aag tca tat ttg aag aca     1817
 Leu Asn Glu His Leu Phe Val Ser Ala Leu Lys Ser Tyr Leu Lys Thr
             520                 525                 530

 ttt tcc tac tca aac gct gag caa gat gat cta tgg agg cat ttt caa     1865
 Phe Ser Tyr Ser Asn Ala Glu Gln Asp Asp Leu Trp Arg His Phe Gln
         535                 540                 545

 atg gcc ata gat gac cag agt aca gtt att ttg cca gca aca ata aaa     1913
 Met Ala Ile Asp Asp Gln Ser Thr Val Ile Leu Pro Ala Thr Ile Lys
     550                 555                 560

 aac ata atg gac agt tgg aca cac cag agt ggt ttt cca gtg atc act     1961
 Asn Ile Met Asp Ser Trp Thr His Gln Ser Gly Phe Pro Val Ile Thr
 565                 570                 575                 580

 tta aat gtg tct act ggc gtc atg aaa cag gag cca ttt tat ctt gaa     2009
 Leu Asn Val Ser Thr Gly Val Met Lys Gln Glu Pro Phe Tyr Leu Glu
                 585                 590                 595

 aac att aaa aat cgg act ctt cta acc agc aat gac aca tgg att gtc     2057
 Asn Ile Lys Asn Arg Thr Leu Leu Thr Ser Asn Asp Thr Trp Ile Val
             600                 605                 610

 cct att ctt gga tca aaa atg gaa cta cac aag ctt tag tctggctaga      2106
 Pro Ile Leu Gly Ser Lys Met Glu Leu His Lys Leu 
         615                 620

 tcacagcagc aaagtattcc cagacatgca agttcagaat tctgaccatg actgggtgca   2166

 c                                                                   2167




      <210> 595
      <211> 1126
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (138)..(764)

      <400> 595
 tgtcgttgtt ctgagtgtcc ttgctggcca tcgctgtgga ccgatacttg cgggtcaagc     60

 ttaccgtcag attcagaatt cctgggctcc ctgggtgcat tctatcattc cagttgaaag    120

 tttgcttcct tccagtc   atg tgg ctc ttc att cta ctc tcc ttg gct ctc     170
                      Met Trp Leu Phe Ile Leu Leu Ser Leu Ala Leu
                        1               5                  10

 atc tca gat gcc atg gtc atg gat gaa aag gtc aag aga agc ttt gtg      218
 Ile Ser Asp Ala Met Val Met Asp Glu Lys Val Lys Arg Ser Phe Val
              15                  20                  25

 ctg gac acg gct tct gcc atc tgc aac tac aat gcc cac tac aag aat      266
 Leu Asp Thr Ala Ser Ala Ile Cys Asn Tyr Asn Ala His Tyr Lys Asn
          30                  35                  40

 cac ccc aaa tac tgg tgc cga ggc tat ttc cgt gac tac tgc aac atc      314
 His Pro Lys Tyr Trp Cys Arg Gly Tyr Phe Arg Asp Tyr Cys Asn Ile
      45                  50                  55

 atc gcc ttc tcc cct aac agc acc aat cat gtg gcc ctg agg gac aca      362
 Ile Ala Phe Ser Pro Asn Ser Thr Asn His Val Ala Leu Arg Asp Thr
  60                  65                  70                  75

 ggg aac cag ctc att gtc act atg tcc tgc ctg acc aaa gag gac acg      410
 Gly Asn Gln Leu Ile Val Thr Met Ser Cys Leu Thr Lys Glu Asp Thr
                  80                  85                  90

 ggc tgg tac tgg tgt ggc atc cag cgg gac ttt gcc agg gat gac atg      458
 Gly Trp Tyr Trp Cys Gly Ile Gln Arg Asp Phe Ala Arg Asp Asp Met
              95                 100                 105

 gat ttt aca gag ctg att gta act gac gac aaa gga acc ctg gcc aat      506
 Asp Phe Thr Glu Leu Ile Val Thr Asp Asp Lys Gly Thr Leu Ala Asn
         110                 115                 120

 gac ttt tgg tct ggg aaa gac cta tca ggc aac aaa acc aga agc tgc      554
 Asp Phe Trp Ser Gly Lys Asp Leu Ser Gly Asn Lys Thr Arg Ser Cys
     125                 130                 135

 aag gct ccc aaa gtt gtc cgc aag gct gac cgc tcc agg acg tcc att      602
 Lys Ala Pro Lys Val Val Arg Lys Ala Asp Arg Ser Arg Thr Ser Ile
 140                 145                 150                 155

 ctc atc att tgc ata ctg atc acg ggt ttg gga atc atc tct gta atc      650
 Leu Ile Ile Cys Ile Leu Ile Thr Gly Leu Gly Ile Ile Ser Val Ile
                 160                 165                 170

 agt cat ttg acc aaa agg agg aga agt caa agg aat aga agg gta ggc      698
 Ser His Leu Thr Lys Arg Arg Arg Ser Gln Arg Asn Arg Arg Val Gly
             175                 180                 185

 aac act ttg aag ccc ttc tcg cgt gtc ctg act cca aag gaa atg gct      746
 Asn Thr Leu Lys Pro Phe Ser Arg Val Leu Thr Pro Lys Glu Met Ala
         190                 195                 200

 cct act gaa cag atg tga ctgaag atttttttaa tttagttcat aaagtgatgc      800
 Pro Thr Glu Gln Met 
     205

 tacaacagaa taatcaccat gacaactggc ccacacctca gagactgatt ctgatctccc    860

 aggaattctg aaggaccctc tatccttgac aacaatcatt tgcagccagg tagcaacggc    920

 ggtagtcaga ggagctatga tagaccacac ccaagcaagg ctgccctcaa ataacatctc    980

 aagatcttag ttcttatgca ttccatcagt cagaagtgaa gaagaggtgg agaatctgga   1040

 ttggggacca ggaaatcact tgtattttgt tagccaataa attcctagcc agtgttgaat   1100

 gaaaaaaaaa aaaaaaaaaa agatat                                        1126




      <210> 596
      <211> 638
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (43)..(375)

      <400> 596
 ggactttgga cagtggggag caggcccaac agggccactc gg   atg tgg tca ctc      54
                                                  Met Trp Ser Leu
                                                    1

 tgg att tgg gtg gat cag cac caa gct aga ctc atc ccc agc ccc cag      102
 Trp Ile Trp Val Asp Gln His Gln Ala Arg Leu Ile Pro Ser Pro Gln
   5                  10                  15                  20

 gtg ctg ttg ctg ctc ctg cgt gag acc cca tcc aca gct gca gct gtg      150
 Val Leu Leu Leu Leu Leu Arg Glu Thr Pro Ser Thr Ala Ala Ala Val
                  25                  30                  35

 gca ggg tgg cta gtg gtg gcc agc atg gcc ctg ctg cag ctc cac gct      198
 Ala Gly Trp Leu Val Val Ala Ser Met Ala Leu Leu Gln Leu His Ala
              40                  45                  50

 gtg ggg ggc gtg gcc ctg acc agc agc cac ccc tcc atg tgg gcc aca      246
 Val Gly Gly Val Ala Leu Thr Ser Ser His Pro Ser Met Trp Ala Thr
          55                  60                  65

 ggg gag gag ctt agg aag ccg cct tgg caa ggt tcc gca ggc tct gcg      294
 Gly Glu Glu Leu Arg Lys Pro Pro Trp Gln Gly Ser Ala Gly Ser Ala
      70                  75                  80

 tct ggt gtg gaa gag ctc acg ggg aag cac tcc tgc cca gga ccc gag      342
 Ser Gly Val Glu Glu Leu Thr Gly Lys His Ser Cys Pro Gly Pro Glu
  85                  90                  95                 100

 gag ccg gcc acc gtt cag aag gcc cca gct tga aggcctgg agagccgccc      393
 Glu Pro Ala Thr Val Gln Lys Ala Pro Ala 
                 105                 110

 agcagcacaa cacagggaag cttggggagc aaaaggagaa aattgtcatc aaaggatatt    453

 ccagattctt gacagcattc tcgtcatctc tgaggacatc accatcatct caggatgagg    513

 ggcatgaagc tgctgggggc gctgctggca ctggcggccc tactgcaggg ggccgtgtcc    573

 ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc    633

 ctcgg                                                                638




      <210> 597
      <211> 2006
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (246)..(461)

      <400> 597
 agcggggact taggcaaggg gtccaggtca gagtttagag ctttcaaatc ccaacttgcc     60

 cctggggatt gcgcggctga tgtttagaac gcctagtcaa gccaaccggc tcgctcttgt    120

 ttcagcaaac cctgacttac gtctcctatt tgacttgagg cggcacagtg gccaagtcga    180

 ttggccgtgg caagtgaccc tccctgtggc tgaagtgttc tgaggactgg cgagagaggc    240

 gcgcc    atg ctt gcc ccc tgc tca ggt tgg gag ctt ggc tgc ttc cgt     287
          Met Leu Ala Pro Cys Ser Gly Trp Glu Leu Gly Cys Phe Arg
            1               5                  10

 ctc tgt ctc cgt cag gtc cga ctg tgg gct ggc gct ggg cgc tgg gct      335
 Leu Cys Leu Arg Gln Val Arg Leu Trp Ala Gly Ala Gly Arg Trp Ala
  15                  20                  25                  30

 tgc tgg gct tgc caa gcc agg ccg tac agc tca ggt ggg agc gag cgc      383
 Cys Trp Ala Cys Gln Ala Arg Pro Tyr Ser Ser Gly Gly Ser Glu Arg
                  35                  40                  45

 tgg ccc gga tcg gag act gag gtc cct ccg cct ggc ccg gcg cgc cga      431
 Trp Pro Gly Ser Glu Thr Glu Val Pro Pro Pro Gly Pro Ala Arg Arg
              50                  55                  60

 act ctg aag gag tgg aca ctg cag gtt tag a tatcaagtca tcagggtctg      482
 Thr Leu Lys Glu Trp Thr Leu Gln Val 
          65                  70

 gctgtgtaaa agttcaaagt attgagggtg ataattgcaa aattgaaaca gagcatggga    542

 ctagtatctt gcagtctgtt aagggtcaaa aattgcatgt tcaaacaaaa ggaggcaaag    602

 tgatctgtct gggaacagtt tatggaaata tagatattca tgcatcagat aaaagtgctg    662

 tgaccataga taaactgcag ggaagttctg ttactgtatc taccgaagat ggtttgctga    722

 aagccaagta tctttataca gaatcatcat ttctgtcttc tgctgctggg gatattacat    782

 taggaagtgt tcatggtaat tataacatta caaagcaaga tgggtaactt ccaggtagaa    842

 ttcgcttctg gatgtctaaa agcctcaact aatcagggtg ccatagatgt ttatgtcagc    902

 caactgggga aagtggaatt gaaatcccat aaaggttcta ttattgtcaa ggtcccatct    962

 tcacttcaag ctcatttaca gttatcaggg aaagaggttg atgtgaactc agaagtccat   1022

 gttcaggaaa tggctgaagt ttgtaaagat gatgttgtaa cagtgactgg actcatgaat   1082

 caagcaagca aacgtgaaaa atggattaag gctgatgccc caaaaggcac tgtaagtttt   1142

 agaaggcaaa gttggtttca gtccctgaaa ctgcaggact aaaactgatt tgagttggat   1202

 ttatgatttt taacaatgat tcgcagatct gtgactacaa aaatgtaaat cccaccattc   1262

 atataaaggt tgaaaacaac aaattgagaa tgaatactgg tgaactgttt tgggaggctt   1322

 tttcaaaatt tgtgctttgc tattgtattc attttctact gctctgtaac aaattaccac   1382

 aaatttggca gcataaaata atactcattt acagctatgt ctaggttctc cgctcaggga   1442

 atcacaaggc tagaaatcaa gattttggcc aggctgagtt ctcatctgga gtctctggga   1502

 agaaatctac ttccaacttc attcagatta ttgggaaaat ccagttcctt gtgactggat   1562

 gactgaggtc tccattttct tgctggctgt cagccagcaa tcactctaag cttctagagg   1622

 ccacccacat gccttctcat gttgcccctc catcttcaag ccagcagtga tgcgctgagt   1682

 tcttctcatg ctttgaatat ctgacttctt ctgcagccag ctggaagaat atatactttt   1742

 aaagggctca cttgattagg tcaggcccac ccaggataac ctttgttttg ccatataatg   1802

 taacattcat aggagtgatg gcccatcaca ttcagttttc actcccactc aaggaaagga   1862

 gattatacaa aggcatccat catgtgggga caattagctt agaattcttt ataatgtagc   1922

 tctcacatga caggttttct acttagtacc ttttatggca tcaatgtaaa tttaagctgt   1982

 aaataaaaaa caaatatgtg aagc                                          2006




      <210> 598
      <211> 1213
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (214)..(648)

      <400> 598
 gtttagagct ttcaaatccc aacttgcccc tggggattgc gcggctgatg tttagaacgc     60

 ctagtcaagc caaccggctc gctcttgttt cagcaaaccc tgacttacgt ctcctatttg    120

 acttgaggcg gcacagtggc caagtcgatt ggccgtggca agtgaccctc cctgtggctg    180

 aagtgttctg aggactggcg agagaggcgc gcc atg ctt gcc ccc tgc tca ggt     234
                                      Met Leu Ala Pro Cys Ser Gly
                                        1               5

 tgg gag ctt ggc tgc ttc cgt ctc tgt ctc cgt cag gtc cga ctg tgg      282
 Trp Glu Leu Gly Cys Phe Arg Leu Cys Leu Arg Gln Val Arg Leu Trp
          10                  15                  20

 gct ggc gct ggg cgc tgg gct tgc tgg gct tgc caa gcc agg ccg tac      330
 Ala Gly Ala Gly Arg Trp Ala Cys Trp Ala Cys Gln Ala Arg Pro Tyr
      25                  30                  35

 agc tca ggt ggg agc gag cgc tgg ccc gga tcg gag act gag gtc cct      378
 Ser Ser Gly Gly Ser Glu Arg Trp Pro Gly Ser Glu Thr Glu Val Pro
  40                  45                  50                  55

 ccg cct ggc ccg gcg cgc cga act ctg aag gag tgg aca ctg cag gtg      426
 Pro Pro Gly Pro Ala Arg Arg Thr Leu Lys Glu Trp Thr Leu Gln Val
                  60                  65                  70

 agc ccg ttt ggt cgg ctg cgg gcg cgg ctc ccg tgc cac ctg gcc gtg      474
 Ser Pro Phe Gly Arg Leu Arg Ala Arg Leu Pro Cys His Leu Ala Val
              75                  80                  85

 agg ccc ctg gac ccc ctc acc tac ccg gat ggc gac cgc gtg ctg gtc      522
 Arg Pro Leu Asp Pro Leu Thr Tyr Pro Asp Gly Asp Arg Val Leu Val
          90                  95                 100

 gcg gtg tgc ggc gtg gag ggc ggc gtg cgg ggc ctg gac ggc ctg cag      570
 Ala Val Cys Gly Val Glu Gly Gly Val Arg Gly Leu Asp Gly Leu Gln
     105                 110                 115

 gtg aag tac gac gag gat ctg gag gag atg gcc att gtg tct gat act      618
 Val Lys Tyr Asp Glu Asp Leu Glu Glu Met Ala Ile Val Ser Asp Thr
 120                 125                 130                 135

 atc cac ccc cag gcg tcc gtg gag gtt tag a tatcaagtca tcagggtctg      669
 Ile His Pro Gln Ala Ser Val Glu Val 
                 140

 gctgtgtaaa agttcaaagt attgagggtg ataattgcaa aattgaaaca gagcatggga    729

 ctagtatctt gcagtctgtt aaggtaatat aacattacaa agcaagatgg gtaacatcac    789

 agtagattcg tcttctggat gtctaaaagc ctcaactaat cagggtgcca tagatgttta    849

 ttgtcagcca actggggaaa gtggaatttg aaatcccata aaggttctat tattgtcaag    909

 gtcccatctt cacttcaagc tcatttacag ttatcaggga aagaggttga tgtgaactca    969

 gaagtccatg ttcaaggaaa tggctgaagt tcgtaaagat gatgttggta cagtgactgg   1029

 actcttgaaa tcaggcaagc aaacggtgaa aacatcggct taaggctgat gccccaaaag   1089

 gcactgtaag gtttagaagg caaacgttgg gttcagtccc tgaaactggg gacttaaact   1149

 ggtttgcgtg ggattcatga tttttaccat gattcgcgat ctgtgctccc aatgttatcc   1209

 acat                                                                1213




      <210> 599
      <211> 1010
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (463)..(921)

      <220>
      <221> misc_feature
      <222> (1)...(1010)
      <223> n = a,t,c or g

      <400> 599
 taaganggaa agggccaacc accccccccc ccccccnntg gggtttttta taaaatgggg     60

 gcaggtgttt ttctgaaaaa aagcggggag gacaccataa atgtagtagc tctccttaag    120

 ccccaccgct tcccttattt tcccccgtgt tagttgtggg aattggagcg gaacatttcc    180

 caagaaaaca ctataaccac atttnaattt aaacgctcct aagggaaagt ntggccccca    240

 ggaccaaaat atgcggaaga ggctcttaat cccccttcct gctcggtgat gatgcgcgga    300

 tgattataaa ctcttaaaca aaccagcgcc tttctggtgt tccacaaacc agtacgtcgt    360

 tctcttattt ttaatgaggc ggcacagtga ccaagtagtt gcccgtgaca agtaccctcc    420

 cctgtgtctg agttgtttga ggactgcgaa gagaggcgcc cc   atg ctt gcc ccc     474
                                                  Met Leu Ala Pro
                                                    1

 tgc tca ggt tgg gag ctt ggc tgc atc cgt ctc tgt ctc cgt cag gtc      522
 Cys Ser Gly Trp Glu Leu Gly Cys Ile Arg Leu Cys Leu Arg Gln Val
   5                  10                  15                  20

 cga ctg tgg gct ggc gct ggg cgc tgg gct tgc tgg gct tgc caa gcc      570
 Arg Leu Trp Ala Gly Ala Gly Arg Trp Ala Cys Trp Ala Cys Gln Ala
                  25                  30                  35

 agg ccg tac agc tca ggt ggg agc gag cgc tgg ccc gga tcg gag act      618
 Arg Pro Tyr Ser Ser Gly Gly Ser Glu Arg Trp Pro Gly Ser Glu Thr
              40                  45                  50

 gag gtc cct ccg cct ggc ccg gcg cgc cga act ctg aag gag tgg aca      666
 Glu Val Pro Pro Pro Gly Pro Ala Arg Arg Thr Leu Lys Glu Trp Thr
          55                  60                  65

 ctg cag gtg agc ccg ttt ggt cgg ctg cgg gcg cgg ctc ccg tgc cac      714
 Leu Gln Val Ser Pro Phe Gly Arg Leu Arg Ala Arg Leu Pro Cys His
      70                  75                  80

 ctg gcc gtg agg ccc ctg gac ccc ctc acc tac ccg gat ggc gac cgc      762
 Leu Ala Val Arg Pro Leu Asp Pro Leu Thr Tyr Pro Asp Gly Asp Arg
  85                  90                  95                 100

 gtg ctg gtc gcg gtg tgc ggc gtg gag ggc ggc gtg cgg ggc ctg gac      810
 Val Leu Val Ala Val Cys Gly Val Glu Gly Gly Val Arg Gly Leu Asp
                 105                 110                 115

 ggc ctg cag gtg aag tac gac gag gat ctg gag gag atg gcc att gtg      858
 Gly Leu Gln Val Lys Tyr Asp Glu Asp Leu Glu Glu Met Ala Ile Val
             120                 125                 130

 tct gat act atc cac ccc cag gcg tcc gtg gag gtg aac gcg ccc ctg      906
 Ser Asp Thr Ile His Pro Gln Ala Ser Val Glu Val Asn Ala Pro Leu
         135                 140                 145

 aag ttt ggc aag tga agtgaagtga aaacgggttt gggtcccagg gaacgcacag      961
 Lys Phe Gly Lys 
     150

 tgaacttaat aaatgtggtc gacgtgcact tttaaaaaaa aaaaaaaaa               1010




      <210> 600
      <211> 2949
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (421)..(2763)

      <400> 600
 ggtcacttcc gggcaacgga gcccgtggaa ggcggaagtg tgagcgccgc ggcggcagct     60

 gagttgggct gaggtgtccc tagctggctc tgcggctctt ccgggtctgg gctcggagat    120

 tcacaggcgg cccgcgaggc cgagcgaggg acgcatggcc ctgaggcggc cgcagggctt    180

 ggcggggtcc ggaggttgac ctcgcccccg cagccggcct tcgaggctgc ctcctccagg    240

 cagcctctgg ggcccagcgc ccgcgcctgc tcaggctccc gtgttcaggc tgcccatccc    300

 ctccccaccg gcgtcccgga cgttgggacc tgtgaccgtg gcctcgggct gggcttccaa    360

 agccggccgc agcccggcga cccccgaggc ctctcgcccc gggcccctag acctctcact    420
                                                                 
 atg acc gcg gcc gcc gcc tcc aac tgg ggg ctg atc acg aac atc gtg      468
 Met Thr Ala Ala Ala Ala Ser Asn Trp Gly Leu Ile Thr Asn Ile Val
   1               5                  10                  15

 aac agc atc gta ggg gtc agt gtc ctc acc atg ccc ttc tgc ttc aaa      516
 Asn Ser Ile Val Gly Val Ser Val Leu Thr Met Pro Phe Cys Phe Lys
              20                  25                  30

 cag tgc ggc atc gtc ctg ggg gcg ctg ctc ttg gtc ttc tgc tca tgg      564
 Gln Cys Gly Ile Val Leu Gly Ala Leu Leu Leu Val Phe Cys Ser Trp
          35                  40                  45

 atg acg cac cag tcg tgc atg ttc ttg gtg aag tcg gcc agc ctg agc      612
 Met Thr His Gln Ser Cys Met Phe Leu Val Lys Ser Ala Ser Leu Ser
      50                  55                  60

 aag cgg agg acc tac gcc ggc ctg gca ttc cac gcc tac ggg aag gca      660
 Lys Arg Arg Thr Tyr Ala Gly Leu Ala Phe His Ala Tyr Gly Lys Ala
  65                  70                  75                  80

 ggc aag atg ctg gtg gag acc agc atg atc ggg ctg atg ctg ggc acc      708
 Gly Lys Met Leu Val Glu Thr Ser Met Ile Gly Leu Met Leu Gly Thr
                  85                  90                  95

 tgc atc gcc ttc tac gtc gtg atc ggc gac ttg ggg tcc aac ttc ttt      756
 Cys Ile Ala Phe Tyr Val Val Ile Gly Asp Leu Gly Ser Asn Phe Phe
             100                 105                 110

 gcc cgg ctg ttc ggg ttt cag gtg ggc ggc acc ttc cgc atg ttc ctg      804
 Ala Arg Leu Phe Gly Phe Gln Val Gly Gly Thr Phe Arg Met Phe Leu
         115                 120                 125

 ctg ttc gcc gtg tcg ctg tgc atc gtg ctc ccg ctc agc ctg cag cgg      852
 Leu Phe Ala Val Ser Leu Cys Ile Val Leu Pro Leu Ser Leu Gln Arg
     130                 135                 140

 aac atg atg gcc tcc atc cag tcc ttc agc gcc atg gcc ctc ctc ttc      900
 Asn Met Met Ala Ser Ile Gln Ser Phe Ser Ala Met Ala Leu Leu Phe
 145                 150                 155                 160

 tac acc gtg ttc atg ttc gtg atc gtg ctc tcc tct ctc aag cac ggc      948
 Tyr Thr Val Phe Met Phe Val Ile Val Leu Ser Ser Leu Lys His Gly
                 165                 170                 175

 ctc ttc agt ggg cag tgg ctg cgg cgg gtc agc tac gtc cgc tgg gag      996
 Leu Phe Ser Gly Gln Trp Leu Arg Arg Val Ser Tyr Val Arg Trp Glu
             180                 185                 190

 ggc gtc ttc cgc tgc atc ccc atc ttc ggc atg tcc ttc gcc tgc cag     1044
 Gly Val Phe Arg Cys Ile Pro Ile Phe Gly Met Ser Phe Ala Cys Gln
         195                 200                 205

 tcc cag gtg ctg ccc acc tac gac agc ctg gat gag ccg tca gtg aaa     1092
 Ser Gln Val Leu Pro Thr Tyr Asp Ser Leu Asp Glu Pro Ser Val Lys
     210                 215                 220

 acc atg agc tcc ata ttt gct tcc tcc ctt aat gtg gtc acc acc ttc     1140
 Thr Met Ser Ser Ile Phe Ala Ser Ser Leu Asn Val Val Thr Thr Phe
 225                 230                 235                 240

 tac gtc atg gtg ggg ttt ttc ggc tac gtc agc ttc acc gag gcc acg     1188
 Tyr Val Met Val Gly Phe Phe Gly Tyr Val Ser Phe Thr Glu Ala Thr
                 245                 250                 255

 gcc ggc aac gtg ctc atg cac ttt ccc tcc aac ctg gtg acg gag atg     1236
 Ala Gly Asn Val Leu Met His Phe Pro Ser Asn Leu Val Thr Glu Met
             260                 265                 270

 ctc cgt gtg ggc ttc atg atg tca gtg gct gtg ggc ttc ccc atg atg     1284
 Leu Arg Val Gly Phe Met Met Ser Val Ala Val Gly Phe Pro Met Met
         275                 280                 285

 atc ctg cca tgc agg cag gcc ctg agc acg ctg ctg tgt gag cag cag     1332
 Ile Leu Pro Cys Arg Gln Ala Leu Ser Thr Leu Leu Cys Glu Gln Gln
     290                 295                 300

 caa aaa gat ggc acc ttt gca gca ggg ggc tac atg ccc cct ctc cgg     1380
 Gln Lys Asp Gly Thr Phe Ala Ala Gly Gly Tyr Met Pro Pro Leu Arg
 305                 310                 315                 320

 ttt aaa gca ctt acc ctc tct gtg gtg ttt gga acc atg gtt ggt ggc     1428
 Phe Lys Ala Leu Thr Leu Ser Val Val Phe Gly Thr Met Val Gly Gly
                 325                 330                 335

 atc ctt atc ccc aac gtg gag acc atc ctg ggc ctc aca gga gcg acc     1476
 Ile Leu Ile Pro Asn Val Glu Thr Ile Leu Gly Leu Thr Gly Ala Thr
             340                 345                 350

 atg gga agc ctc atc tgc ttc atc tgc ccg gcg ctg atc tac aag aaa     1524
 Met Gly Ser Leu Ile Cys Phe Ile Cys Pro Ala Leu Ile Tyr Lys Lys
         355                 360                 365

 atc cac aag aac gca ctt tcc tcc cag gtg gtg ctg tgg gtc ggc ctg     1572
 Ile His Lys Asn Ala Leu Ser Ser Gln Val Val Leu Trp Val Gly Leu
     370                 375                 380

 ggc gtc ctg gtg gtg agc act gtc acc aca ctg tct gtg agc gag gag     1620
 Gly Val Leu Val Val Ser Thr Val Thr Thr Leu Ser Val Ser Glu Glu
 385                 390                 395                 400

 gtc ccc gag gac ttg gca gag gaa gcc cct ggc ggc cgg ctt gga gag     1668
 Val Pro Glu Asp Leu Ala Glu Glu Ala Pro Gly Gly Arg Leu Gly Glu
                 405                 410                 415

 gcc gag ggt ttg atg aag gtg gag gca gcg cgg ctc tca gcc cag gat     1716
 Ala Glu Gly Leu Met Lys Val Glu Ala Ala Arg Leu Ser Ala Gln Asp
             420                 425                 430

 ccg gtt gtg gcc gtg gct gag gat ggc cgg gag aag ccg aag ctg ccg     1764
 Pro Val Val Ala Val Ala Glu Asp Gly Arg Glu Lys Pro Lys Leu Pro
         435                 440                 445

 aag gag aga gag gag ctg gag cag gcc cag atc aag ggg ccc gtg gat     1812
 Lys Glu Arg Glu Glu Leu Glu Gln Ala Gln Ile Lys Gly Pro Val Asp
     450                 455                 460

 gtg cct gga cgg gaa gat ggc aag gag gca ccg gag gag gca cag ctc     1860
 Val Pro Gly Arg Glu Asp Gly Lys Glu Ala Pro Glu Glu Ala Gln Leu
 465                 470                 475                 480

 gat cgc cct ggg caa ggg att gct gtg cct gtg ggc gag gcc cac cgc     1908
 Asp Arg Pro Gly Gln Gly Ile Ala Val Pro Val Gly Glu Ala His Arg
                 485                 490                 495

 cac gag cct cct gtt cct cac gac aag gtg gtg gta gat gaa ggc caa     1956
 His Glu Pro Pro Val Pro His Asp Lys Val Val Val Asp Glu Gly Gln
             500                 505                 510

 gac cga gag gtg cca gaa gag aac aaa cct cca tcc aga cac gcg ggc     2004
 Asp Arg Glu Val Pro Glu Glu Asn Lys Pro Pro Ser Arg His Ala Gly
         515                 520                 525

 gga aag gct cca ggg gtc cag ggc cag atg gcg ccg cct ctg ccc gac     2052
 Gly Lys Ala Pro Gly Val Gln Gly Gln Met Ala Pro Pro Leu Pro Asp
     530                 535                 540

 tca gaa aga gag aaa caa gag ccg gag cag gga gag gtt ggg aag agg     2100
 Ser Glu Arg Glu Lys Gln Glu Pro Glu Gln Gly Glu Val Gly Lys Arg
 545                 550                 555                 560

 cct gga cag gcc cag gcc ttg gag gag gcg ggt gat ctt cct gaa gat     2148
 Pro Gly Gln Ala Gln Ala Leu Glu Glu Ala Gly Asp Leu Pro Glu Asp
                 565                 570                 575

 ccc cag aaa gtt cca gaa gca gat ggt cag cca gct gtc cag cct gca     2196
 Pro Gln Lys Val Pro Glu Ala Asp Gly Gln Pro Ala Val Gln Pro Ala
             580                 585                 590

 aag gag gac ctg ggg cca gga gac agg ggc ctg cat cct cgg ccc cag     2244
 Lys Glu Asp Leu Gly Pro Gly Asp Arg Gly Leu His Pro Arg Pro Gln
         595                 600                 605

 gca gtg ctg tct gag cag cag aac ggc ctg gcg gtg ggt gga ggg gaa     2292
 Ala Val Leu Ser Glu Gln Gln Asn Gly Leu Ala Val Gly Gly Gly Glu
     610                 615                 620

 aag gcc aag ggg gga ccg ccg cca ggc aac gcc gcc ggg gac aca ggg     2340
 Lys Ala Lys Gly Gly Pro Pro Pro Gly Asn Ala Ala Gly Asp Thr Gly
 625                 630                 635                 640

 cag ccc gca gag gac agc gac cac ggt ggg aag cct ccc ctc cca gcg     2388
 Gln Pro Ala Glu Asp Ser Asp His Gly Gly Lys Pro Pro Leu Pro Ala
                 645                 650                 655

 gag aag ccg gct cca ggg cct ggg ctg ccg ccc gag cct cgc gag cag     2436
 Glu Lys Pro Ala Pro Gly Pro Gly Leu Pro Pro Glu Pro Arg Glu Gln
             660                 665                 670

 agg gac gtg gag cga gcg ggt gga aac cag gcg gcc agc cag ctg gag     2484
 Arg Asp Val Glu Arg Ala Gly Gly Asn Gln Ala Ala Ser Gln Leu Glu
         675                 680                 685

 ggt aag gcc tcc gcc cta cag ccg cct gcc tca ggc cca ggg agc ggc     2532
 Gly Lys Ala Ser Ala Leu Gln Pro Pro Ala Ser Gly Pro Gly Ser Gly
     690                 695                 700

 agc ccc ctc ccc cag ccc tgg ggt gat gcc cag gtc atc ctc ggg agc     2580
 Ser Pro Leu Pro Gln Pro Trp Gly Asp Ala Gln Val Ile Leu Gly Ser
 705                 710                 715                 720

 cct gcc agg ccc ccc ttc tct ttc cag ccg cct gct gag cag acc cct     2628
 Pro Ala Arg Pro Pro Phe Ser Phe Gln Pro Pro Ala Glu Gln Thr Pro
                 725                 730                 735

 cgg aga gct ttc tgc tcc ctt ccc atc agc agc ttg ctt tct ggg aac     2676
 Arg Arg Ala Phe Cys Ser Leu Pro Ile Ser Ser Leu Leu Ser Gly Asn
             740                 745                 750

 ctt tta tct gcc tta ctc ccc ttt aaa cac ctg cgg cat cgt cac atg     2724
 Leu Leu Ser Ala Leu Leu Pro Phe Lys His Leu Arg His Arg His Met
         755                 760                 765

 gct tgt gat tac cgt ttt atc tcc ctt gct ccc ctt taa aacacctgcg      2773
 Ala Cys Asp Tyr Arg Phe Ile Ser Leu Ala Pro Leu 
     770                 775                 780

 gcattgtcac ttggcttgtg attaccattt cgtctttaaa gcaggtttgt taacagtttt   2833

 aacactcgga gtatttaaag ccagccaggt gtgggcgtgc ctgcacccag atgtggaggt   2893

 ttattttaag gctgtgcccc aaggggaccc agccttaaaa aaaaccggcg cggccg       2949




      <210> 601
      <211> 1142
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(728)

      <400> 601
 ggggtcgctg agaaccccgg ggttccgcgg tggaggggtg ctatactggg   atg cag      56
                                                          Met Gln
                                                            1

 gcg cgg ctg ggg act ggc agc aat cat gcc ctg gga gct aac gta gag      104
 Ala Arg Leu Gly Thr Gly Ser Asn His Ala Leu Gly Ala Asn Val Glu
           5                  10                  15

 ctt tgg ata atg ctt ttg caa gtt gta cga gaa ggg aag ttc tcg ggg      152
 Leu Trp Ile Met Leu Leu Gln Val Val Arg Glu Gly Lys Phe Ser Gly
      20                  25                  30

 ttt ctg acc tcc tgc agc ctc ctc ttg cct cgg gct gcc cag atc ttg      200
 Phe Leu Thr Ser Cys Ser Leu Leu Leu Pro Arg Ala Ala Gln Ile Leu
  35                  40                  45                  50

 gcg gct gag gct ggc tta cct tcg agc cgt tcc ttc atg gga ttt gct      248
 Ala Ala Glu Ala Gly Leu Pro Ser Ser Arg Ser Phe Met Gly Phe Ala
                  55                  60                  65

 gct ccc ttc acc aac aag cga aag gct tac tcg gag cgt aga atc atg      296
 Ala Pro Phe Thr Asn Lys Arg Lys Ala Tyr Ser Glu Arg Arg Ile Met
              70                  75                  80

 ggg tac tca atg cag gag atg tat gag gtg gtg tcc aac gtc cag gag      344
 Gly Tyr Ser Met Gln Glu Met Tyr Glu Val Val Ser Asn Val Gln Glu
          85                  90                  95

 tat cgt gag ttt gtg ccc tgg tgt aag aag tct ctg gtg gta tcc agc      392
 Tyr Arg Glu Phe Val Pro Trp Cys Lys Lys Ser Leu Val Val Ser Ser
     100                 105                 110

 cgt aag ggt cat ttg aaa gcc cag ctg gag gtt ggc ttt cca cct gtc      440
 Arg Lys Gly His Leu Lys Ala Gln Leu Glu Val Gly Phe Pro Pro Val
 115                 120                 125                 130

 atg gaa cgt tac acc tct gca gtt tcc atg gtc aaa cct cac atg gtc      488
 Met Glu Arg Tyr Thr Ser Ala Val Ser Met Val Lys Pro His Met Val
                 135                 140                 145

 aag gct gtt tgt act gat ggc aag ctc ttc aac cac tta gag act att      536
 Lys Ala Val Cys Thr Asp Gly Lys Leu Phe Asn His Leu Glu Thr Ile
             150                 155                 160

 tgg cga ttc agc cct ggt att cct gcc tat cct cga acc tgc act gtg      584
 Trp Arg Phe Ser Pro Gly Ile Pro Ala Tyr Pro Arg Thr Cys Thr Val
         165                 170                 175

 gac ttt tcg att tcc ttt gaa ttt cgt tct ctg ctg cac tcc cag ctg      632
 Asp Phe Ser Ile Ser Phe Glu Phe Arg Ser Leu Leu His Ser Gln Leu
     180                 185                 190

 gac acc atg ttt ttg atg agg ttg tca aac aga atg ttg ctg cct ttg      680
 Asp Thr Met Phe Leu Met Arg Leu Ser Asn Arg Met Leu Leu Pro Leu
 195                 200                 205                 210

 agc gtc ggg cag aca cca agt ttg gtc cag aaa cag cat ccc ccg tga      728
 Ser Val Gly Gln Thr Pro Ser Leu Val Gln Lys Gln His Pro Pro 
                 215                 220                 225

 actgatgttc catgaggtgc accagacttg aggcaaggga tgctccctga gctcccttct    788

 accccacttc cctacacaat tctcttattt attgggttgg tcctgttcca atttgaaagg    848

 agtctgtgtt cataatactg tttctcctct caatttccca gaaatgggtt ctatgctggt    908

 ggaaatgtgg gggacagaga acgccaggat gtggaatgag atgtgtagga agggtcaggc    968

 catgtaggag acaatatgct ggagacttta tacgaataga taagattgtg gtgcaggact   1028

 ttaagaactt atgttgacgg agagatctca ggtgaaatgg gtttgcaaga ggggaaatac   1088

 agtgatcgga aggaggacga aaaaggtagg aggggaaagg taccgggaag aagg         1142




      <210> 602
      <211> 1725
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(1050)

      <220>
      <221> misc_feature
      <222> (1)...(1725)
      <223> n = a,t,c or g

      <400> 602
 ggagaagggg aantggggcg cttgagggga ttataatttc tttaaaaaga ggggagggga     60

 gaggcc   atg gcc gtc cca gcc aag aaa agg aag atg aac ttc tca gag     108
          Met Ala Val Pro Ala Lys Lys Arg Lys Met Asn Phe Ser Glu
            1               5                  10

 cgg gag gtg gag atc atc gtg gag gag ctg gag ctg aag aag cac ctg      156
 Arg Glu Val Glu Ile Ile Val Glu Glu Leu Glu Leu Lys Lys His Leu
  15                  20                  25                  30

 ctg gtg aac cac ttc aac gcc ggg gta ccc ctg gcc gcc aag agt gcg      204
 Leu Val Asn His Phe Asn Ala Gly Val Pro Leu Ala Ala Lys Ser Ala
                  35                  40                  45

 gcc tgg cac ggc atc ctg aga agg gtc aac gcc gtg gcc acc tgc cgc      252
 Ala Trp His Gly Ile Leu Arg Arg Val Asn Ala Val Ala Thr Cys Arg
              50                  55                  60

 aga gag ctg cct gag gtc aag aag aag tgg tct gac ctc aag acc gag      300
 Arg Glu Leu Pro Glu Val Lys Lys Lys Trp Ser Asp Leu Lys Thr Glu
          65                  70                  75

 gtc cgt cgc aag gtt gcc cag gtc cgg gcc gcc gtg gag ggt ggt gag      348
 Val Arg Arg Lys Val Ala Gln Val Arg Ala Ala Val Glu Gly Gly Glu
      80                  85                  90

 gcg ccg ggg ccc act gag gag gac gga gct ggg ggg cct ggg aca ggc      396
 Ala Pro Gly Pro Thr Glu Glu Asp Gly Ala Gly Gly Pro Gly Thr Gly
  95                 100                 105                 110

 ggt ggc agt ggc ggc ggt ggc cca gct gta gcc cca gtg ctg ctg acc      444
 Gly Gly Ser Gly Gly Gly Gly Pro Ala Val Ala Pro Val Leu Leu Thr
                 115                 120                 125

 ccc atg caa caa cgt atc tgc aac ctg ctg ggc gag gcc acc atc atc      492
 Pro Met Gln Gln Arg Ile Cys Asn Leu Leu Gly Glu Ala Thr Ile Ile
             130                 135                 140

 agc ctg ccc agc acc aca gag atc cac cct gtg gcc ctc gga ccc tcg      540
 Ser Leu Pro Ser Thr Thr Glu Ile His Pro Val Ala Leu Gly Pro Ser
         145                 150                 155

 gcc acc gca gcc gca gcc acg gtc acc ctg aca cag atc ccc aca gag      588
 Ala Thr Ala Ala Ala Ala Thr Val Thr Leu Thr Gln Ile Pro Thr Glu
     160                 165                 170

 acc acc tat cac acg ctg gag gag ggc gtg gtg gag tac tgc acg gct      636
 Thr Thr Tyr His Thr Leu Glu Glu Gly Val Val Glu Tyr Cys Thr Ala
 175                 180                 185                 190

 gag gcg ccc cca cct ctg cca cca gag acc cct gtg gac atg atg gcc      684
 Glu Ala Pro Pro Pro Leu Pro Pro Glu Thr Pro Val Asp Met Met Ala
                 195                 200                 205

 cag cat gca gac acg tcg gtc aag ccg caa gcg ctc aag agc cgc att      732
 Gln His Ala Asp Thr Ser Val Lys Pro Gln Ala Leu Lys Ser Arg Ile
             210                 215                 220

 gct ctc aac tcc gcc aag ctg ata cag gag cag cgg gtc acc aac ctg      780
 Ala Leu Asn Ser Ala Lys Leu Ile Gln Glu Gln Arg Val Thr Asn Leu
         225                 230                 235

 cat gtg aag gag atc gca cag cac ctg gaa cag cag aac gac cta ctg      828
 His Val Lys Glu Ile Ala Gln His Leu Glu Gln Gln Asn Asp Leu Leu
     240                 245                 250

 cag atg atc cgc cgc tcc cag gaa gtg cag gcc tgt gcc cag gag cgc      876
 Gln Met Ile Arg Arg Ser Gln Glu Val Gln Ala Cys Ala Gln Glu Arg
 255                 260                 265                 270

 cag gcc cag gcc atg gag ggc aca cag gct gcc ctg agc gtc ctc atc      924
 Gln Ala Gln Ala Met Glu Gly Thr Gln Ala Ala Leu Ser Val Leu Ile
                 275                 280                 285

 cag gtc ctc cgg cct atg atc aaa gat ttc cgc cgc tac ctg cag agc      972
 Gln Val Leu Arg Pro Met Ile Lys Asp Phe Arg Arg Tyr Leu Gln Ser
             290                 295                 300

 aac aca gct aac ccg gcc ccc gcc tct gac cct ggg cag gtg gcc cag     1020
 Asn Thr Ala Asn Pro Ala Pro Ala Ser Asp Pro Gly Gln Val Ala Gln
         305                 310                 315

 aat ggg cag cca gac agc atc atc cag tga g ggcaggggtc aggccagcct     1071
 Asn Gly Gln Pro Asp Ser Ile Ile Gln 
     320                 325

 tctgccatga tgggatgaaa actccatgga cttactcacc atcaattacc aaggcccttg   1131

 catctcccca gatcgtttcc caagtttggc gatttgctgt cggtgcctca gccacatatg   1191

 accaatggtt acaactcagg gctccagacc tcagctaaaa agagaagacg ctgccctcct   1251

 gggcacgaac gtttagaatg ctcaactcct ctattgtgac cacaggaagg tggccctgaa   1311

 gatgcaccga agacagctgg gaggtgactg ctgtactgtc agcctctctg tggaggcatt   1371

 cgtgcagtgc cagctaaaag ggaggtgaag ggggatatcg gacccagcga gggagttgct   1431

 ggtagaagga aagctcttct cagtgtggct ggattaagag cagcctagca gcttgggcac   1491

 ctccactctg tgcggtctga tggccccagc aaggtcgctg cagggacttc ctgaggactt   1551

 ggtttggttt ttttctgggg ttggaaatct gagccaatat tgtgtctgtt ccatttgggt   1611

 atgaagagga agtctggatc acttaaactg actagttatt tccgggtcat aattttaaat   1671

 taaagacata tcactttttt ataccaaaac aaacaagaaa aacccgagtt tcta         1725




      <210> 603
      <211> 2650
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (614)..(1015)

      <400> 603
 ggcgggaaga ctacaatccc agcatgcacc tggctaagag acagttcctg tcactggagg     60

 aagaggcgga agactacaat cccagccagc accgggctca gggaaattgg ctgcaggact    120

 acaatgccag catgcagcgg gttcatggac agtgtgtatc actggaggaa gacgtggagc    180

 tctgcgtgcc tcgctgggct tgcagggaga tgcagtctca taactacccc agtcgtttgg    240

 tcgcagggct gcagcagtac aatttcagca tatctttggc tcagggagag tgcactagtc    300

 actggaggaa gaggtaggtc tgtgcgcacc tctctgggct tgctgggaga ggtagtctca    360

 taaacactac cagccctttc atcacatcgc tgtaggacta caattccagc atgcacgggg    420

 cgccggggca gtccgcctca ctggaggaag agaaagacgt gtgagcgcct tgctgggctt    480

 tctgggagat gttgtctctt tatttctccc agccctttgg tcacagggct tcaagactac    540

 aatcccagca tgcatcctgc tcagggacaa cgcgcgtcac tgtaggaaga ggtggacctg    600

 tgctgttctc gct   atg ctt ttt ggg ata cgt att ctc gta aac act ccc     649
                  Met Leu Phe Gly Ile Arg Ile Leu Val Asn Thr Pro
                    1               5                  10

 agc cct ttg gtc act ggg ctg cat cac tac aat ccc agc ata cat cgg      697
 Ser Pro Leu Val Thr Gly Leu His His Tyr Asn Pro Ser Ile His Arg
          15                  20                  25

 gat cag gga gag tgc gct aat cag tgg aga aag ggg cga ggc tct gca      745
 Asp Gln Gly Glu Cys Ala Asn Gln Trp Arg Lys Gly Arg Gly Ser Ala
      30                  35                  40

 cac ctc gct ggt ctt gct ggg aga tgc agt ctc ata aac act ccc agc      793
 His Leu Ala Gly Leu Ala Gly Arg Cys Ser Leu Ile Asn Thr Pro Ser
  45                  50                  55                  60

 cct ttg gtc act ggg ctg cag cgc tac aat cct agc atg gac cgg gcg      841
 Pro Leu Val Thr Gly Leu Gln Arg Tyr Asn Pro Ser Met Asp Arg Ala
                  65                  70                  75

 cag gga atg tgc gcg tca ctg gag gaa gag gca ggg ttg tgc aag cct      889
 Gln Gly Met Cys Ala Ser Leu Glu Glu Glu Ala Gly Leu Cys Lys Pro
              80                  85                  90

 ctc tgg gct tgg tgg gag ttg cag tct cat aaa cac tcc cag acc tct      937
 Leu Trp Ala Trp Trp Glu Leu Gln Ser His Lys His Ser Gln Thr Ser
          95                 100                 105

 cat cac cgg gct gca gga cta caa tcc cag cat gca ccc ggc tca ggg      985
 His His Arg Ala Ala Gly Leu Gln Ser Gln His Ala Pro Gly Ser Gly
     110                 115                 120

 aga gtg cgc att act gga gga aaa gtc tag g ctgtggatgc ctccttctgc     1036
 Arg Val Arg Ile Thr Gly Gly Lys Val 
 125                 130

 ttgctgggag atgtagtttc ataaagactc ccagaacttg tgtcacaggg ctgcaggact   1096

 accatcccat tatgcactgg ggtcagggac acggcccgtc agtggagaaa gaggcggggc   1156

 tgtgtgcgtc tccttcggct tgctgggaga tgtattctta taaacactcc cagccctttg   1216

 gtcaaagggc tacaggacta caatcccagc atgtgccagt ctcgggggcg aggtacaggc   1276

 ctggaagaag gggcagagtg gtacacgccc cacctaatat gctgggagct gtagtctgtt   1336

 aactgctctc agcctgtttg tcggtaggct tcagaactat aatcacagca tgtaccggga   1396

 tccggggtgc atagccctgg agggaggggc acagcggtgt ggacttcccg gtgtccaaag   1456

 cactgctgag ttcttatgct atgccgactc tttgccaagg agaatgagta cataggtgga   1516

 cctagaggac aggtctgcgc tgagcattga ggagggtatt accctacata ggcaccttac   1576

 ctttgcccaa atcgggcggg ttgtcctcaa ctgattggcc ctatccttct caagttcctc   1636

 tttcagctgc acccagggtt ctttccagag cattgcgcct tctgcagccc agggcgctgc   1696

 cttctttcct aaactgctgt ggaaactgtc ctgatgtctg agacactgtc cattgtgccg   1756

 cagccctctt tttttctcta gccaagcctc atgctcaaca gcttttgaga gaaatcttcc   1816

 acgtggcctg cttatgaaca gcttcagaat tctgtagggg gtgacaaggt ctgtggcttc   1876

 ctggaaatgt cactctcaat ggcgcctttt tcacgaatgt gaaagttgag gcatcaggaa   1936

 ggttaattat tgggttgcac aaaatctgct aagagcaaag gagaaaacct catttccgag   1996

 gcatgagtct tgtgagccat tttcatcaac ccatttaagt ggacaagctc caaaatgaaa   2056

 cctgaagctg ctgactattt aggcatttta cacttgaaat catcggtctc atctcaagtc   2116

 actcctgact tgccagtgtc tcagaaacac aaatgggacc ggatccctca ggagcagata   2176

 gtgttccagc tttgttggag cgacatttaa gatgtggagc acttggggtc gtttgaaacc   2236

 cgctatcttc agtagggact tttacttcta gagaacatgt gcattttgat tttatctgtc   2296

 ctcaaactga acttttgctc attttaatag taaaaacaca ttcctaggtg gagacttaag   2356

 atgctaatga gacatgcaat gtatgcacaa atatgtacag ttagtgcaca tgtgcaccca   2416

 gaagaccact caaaacatgc ttacactaac acttctttcc accttcttat gaataatcgt   2476

 gcaaaacccc cagaaggagg gtttctccag taacaattaa tggtgtctca ctcttatgag   2536

 cagcctgccc tggaatctct ttctcagaat gtaccgtcta ttctgcactt aattttcaaa   2596

 gtagtctttt ctttttttgt gtgcaataaa ttactctatg ctgtaaaaaa aaaa         2650




      <210> 604
      <211> 1510
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1510)

      <400> 604
  atg gct cca gga ccc ttc tcc tcg gcc ctc ctc tcg ccg ccg ccc gct      48
  Met Ala Pro Gly Pro Phe Ser Ser Ala Leu Leu Ser Pro Pro Pro Ala
    1               5                  10                  15

 gcc ctg ccc ttt ctg ctg ctg ctc tgg gcg ggg gca tct cgt ggc cag       96
 Ala Leu Pro Phe Leu Leu Leu Leu Trp Ala Gly Ala Ser Arg Gly Gln
              20                  25                  30

 ccc tgc ccc ggc cgc tgc atc tgc cag aac gtg gcg ccc aca ctg aca      144
 Pro Cys Pro Gly Arg Cys Ile Cys Gln Asn Val Ala Pro Thr Leu Thr
          35                  40                  45

 atg ctg tgc gcc aag acc ggc ttg ctc ttt gtg ccg ccc gcc atc gac      192
 Met Leu Cys Ala Lys Thr Gly Leu Leu Phe Val Pro Pro Ala Ile Asp
      50                  55                  60

 cgg cgc gtg gtg gag ctg cgg ctc acc gac aac ttc atc gcc gcc gtg      240
 Arg Arg Val Val Glu Leu Arg Leu Thr Asp Asn Phe Ile Ala Ala Val
  65                  70                  75                  80

 cgc cgc cga gac ttc gcc aac atg acc agc ctg gtg cac ctc act ctc      288
 Arg Arg Arg Asp Phe Ala Asn Met Thr Ser Leu Val His Leu Thr Leu
                  85                  90                  95

 tcc cgg aac acc atc ggc cag gtg gca gct ggc gcc ttc gcc gac ctg      336
 Ser Arg Asn Thr Ile Gly Gln Val Ala Ala Gly Ala Phe Ala Asp Leu
             100                 105                 110

 cgt gcc ctc cgg gcc ctg cac ctg gac agc aac cgc ctg gcg gag gtg      384
 Arg Ala Leu Arg Ala Leu His Leu Asp Ser Asn Arg Leu Ala Glu Val
         115                 120                 125

 cgc ggc gac cag ctc cgc ggc ctg ggc aac ctc cgc cac ctg atc ctt      432
 Arg Gly Asp Gln Leu Arg Gly Leu Gly Asn Leu Arg His Leu Ile Leu
     130                 135                 140

 gga aac aac cag atc cgc cgg gtg gag tcg gcg gcc ttt gac gcc ttc      480
 Gly Asn Asn Gln Ile Arg Arg Val Glu Ser Ala Ala Phe Asp Ala Phe
 145                 150                 155                 160

 ctg tcc acc gtg gag gac ctg gat ctg tcc tac aac aac ctg gag gcc      528
 Leu Ser Thr Val Glu Asp Leu Asp Leu Ser Tyr Asn Asn Leu Glu Ala
                 165                 170                 175

 ctg ccg tgg gag gcg gtg ggc cag atg gtg aac cta aac acc ctc acg      576
 Leu Pro Trp Glu Ala Val Gly Gln Met Val Asn Leu Asn Thr Leu Thr
             180                 185                 190

 ctg gac cac aac ctc atc gac cac atc gcg gag ggg acc ttc gtg cag      624
 Leu Asp His Asn Leu Ile Asp His Ile Ala Glu Gly Thr Phe Val Gln
         195                 200                 205

 ctt cac aag ctg gtc cgt ctg gac atg acc tcc aac cgc ctg cat aaa      672
 Leu His Lys Leu Val Arg Leu Asp Met Thr Ser Asn Arg Leu His Lys
     210                 215                 220

 ctc ccg ccc gac ggg ctc ttc ctg agg tcg cag ggc acc ggg ccc aag      720
 Leu Pro Pro Asp Gly Leu Phe Leu Arg Ser Gln Gly Thr Gly Pro Lys
 225                 230                 235                 240

 ccg ccc acc ccg ctg acc gtc agc ttc ggc ggc aac ccc ctg cac tgc      768
 Pro Pro Thr Pro Leu Thr Val Ser Phe Gly Gly Asn Pro Leu His Cys
                 245                 250                 255

 aac tgc gag ctg ctc tgg ctg cgg cgg ctg acc cgc gag gac gac tta      816
 Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Thr Arg Glu Asp Asp Leu
             260                 265                 270

 gag acc tgc gcc acg ccc gaa cac ctc acc gac cgc tac ttc tgg tcc      864
 Glu Thr Cys Ala Thr Pro Glu His Leu Thr Asp Arg Tyr Phe Trp Ser
         275                 280                 285

 atc ccc gag gag gag ttc ctg tgt gag ccc ccg ctg atc aca cgg cag      912
 Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu Ile Thr Arg Gln
     290                 295                 300

 gcg ggg ggc cgg gcc ctg gtg gtg gaa ggc cag gcg gtg agc ctg cgc      960
 Ala Gly Gly Arg Ala Leu Val Val Glu Gly Gln Ala Val Ser Leu Arg
 305                 310                 315                 320

 tgc cga gcg gtg ggt gac ccc gag ccg gtg gtg cac tgg gtg gca cct     1008
 Cys Arg Ala Val Gly Asp Pro Glu Pro Val Val His Trp Val Ala Pro
                 325                 330                 335

 gat ggg cgg ctg ctg ggg aac tcc agc cgg acc cgg gtc cgg ggg gac     1056
 Asp Gly Arg Leu Leu Gly Asn Ser Ser Arg Thr Arg Val Arg Gly Asp
             340                 345                 350

 ggg acg ctg gat gtg acc atc acc acc ttg agg gac agt ggc acc ttc     1104
 Gly Thr Leu Asp Val Thr Ile Thr Thr Leu Arg Asp Ser Gly Thr Phe
         355                 360                 365

 act tgt atc gcc tcc aat gct gct ggg gaa gcg acg gcg ccc gtg gag     1152
 Thr Cys Ile Ala Ser Asn Ala Ala Gly Glu Ala Thr Ala Pro Val Glu
     370                 375                 380

 gtg tgc gtg gta cct ctg cct ctg atg gca ccc ccg ccg gct gcc ccg     1200
 Val Cys Val Val Pro Leu Pro Leu Met Ala Pro Pro Pro Ala Ala Pro
 385                 390                 395                 400

 ccg cct ctc acc gag ccc ggc tcc tct gac atc gcc acg ccg ggc aga     1248
 Pro Pro Leu Thr Glu Pro Gly Ser Ser Asp Ile Ala Thr Pro Gly Arg
                 405                 410                 415

 cca ggt gcc aac gat tct gcg gct gag cgt cgg ctc gtg gca gcc gag     1296
 Pro Gly Ala Asn Asp Ser Ala Ala Glu Arg Arg Leu Val Ala Ala Glu
             420                 425                 430

 ctc acc tcg aac tcc gtg ctc atc cgc tgg cca gcc cag agg cct gtg     1344
 Leu Thr Ser Asn Ser Val Leu Ile Arg Trp Pro Ala Gln Arg Pro Val
         435                 440                 445

 ccc gga ata cgc atg tac cag gtt cag tac aac agt tcc gtt gat gac     1392
 Pro Gly Ile Arg Met Tyr Gln Val Gln Tyr Asn Ser Ser Val Asp Asp
     450                 455                 460

 tcc ctc gtc tta cag gtg ggt gcg ggt gct gca gtc cca ggg cct cct     1440
 Ser Leu Val Leu Gln Val Gly Ala Gly Ala Ala Val Pro Gly Pro Pro
 465                 470                 475                 480

 ccc aag ccc agg ggg acc ctc cct ccc acc tgc cca ttc cct tgg cct     1488
 Pro Lys Pro Arg Gly Thr Leu Pro Pro Thr Cys Pro Phe Pro Trp Pro
                 485                 490                 495

 tct tgc tca gcc agg gtt cta g                                       1510
 Ser Cys Ser Ala Arg Val Leu 
             500





      <210> 605
      <211> 4214
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (13)..(3297)

      <220>
      <221> misc_feature
      <222> (1)...(4214)
      <223> n = a,t,c or g

      <400> 605
 tacactccag tc    atg gcg gcc cga cag gcc gtg ggc agc ggg gct cag      48
                  Met Ala Ala Arg Gln Ala Val Gly Ser Gly Ala Gln
                    1               5                  10

 gag aca tgc ggt ctg gat cgg att ttg gag gca ttg aag ctg ctg ctg       96
 Glu Thr Cys Gly Leu Asp Arg Ile Leu Glu Ala Leu Lys Leu Leu Leu
          15                  20                  25

 agc ccg gga ggc tcg ggc tca agt tca cta cag gtc aca aaa cat gat      144
 Ser Pro Gly Gly Ser Gly Ser Ser Ser Leu Gln Val Thr Lys His Asp
      30                  35                  40

 gtc ttg ttg gct act tta aaa tct aac ctg tct gct ttg gag gac aag      192
 Val Leu Leu Ala Thr Leu Lys Ser Asn Leu Ser Ala Leu Glu Asp Lys
  45                  50                  55                  60

 ttt ctg aag gat cct cag tgg aag aat ctg aaa ctc cta aga gat gaa      240
 Phe Leu Lys Asp Pro Gln Trp Lys Asn Leu Lys Leu Leu Arg Asp Glu
                  65                  70                  75

 att gct gat aag gca gaa tgg cca caa aac tct gtg gat gtc act tgg      288
 Ile Ala Asp Lys Ala Glu Trp Pro Gln Asn Ser Val Asp Val Thr Trp
              80                  85                  90

 agt ttt acc tct caa acc ttg ttg ttg ctt ttg tgc ttg aag gaa acc      336
 Ser Phe Thr Ser Gln Thr Leu Leu Leu Leu Leu Cys Leu Lys Glu Thr
          95                 100                 105

 atg atc cgc ctt gca gct aat ttc aat cca ggt aaa ccc aac cct agg      384
 Met Ile Arg Leu Ala Ala Asn Phe Asn Pro Gly Lys Pro Asn Pro Arg
     110                 115                 120

 act ccg gaa gtt gct cct gcc ctg agc ccc gat gca ctt agt atc tca      432
 Thr Pro Glu Val Ala Pro Ala Leu Ser Pro Asp Ala Leu Ser Ile Ser
 125                 130                 135                 140

 caa cag aag act gtc cag ttc gtt ttg cag ttt gta gtt acc ttg ggt      480
 Gln Gln Lys Thr Val Gln Phe Val Leu Gln Phe Val Val Thr Leu Gly
                 145                 150                 155

 atc tgc ccc tat ctc atg cct ggt gtt gga gtc cct ttg aga tat aga      528
 Ile Cys Pro Tyr Leu Met Pro Gly Val Gly Val Pro Leu Arg Tyr Arg
             160                 165                 170

 act gaa ttt ggt gcc gtc gtt caa gac gtg gtg tgt ttt gat gct gcc      576
 Thr Glu Phe Gly Ala Val Val Gln Asp Val Val Cys Phe Asp Ala Ala
         175                 180                 185

 ccc gat gca act cga aga ctg tac acc agc tgc aag gcc ctt ctg aat      624
 Pro Asp Ala Thr Arg Arg Leu Tyr Thr Ser Cys Lys Ala Leu Leu Asn
     190                 195                 200

 gtt gct cag cac aca tct ctg ggg agc ttg atc ttc tgc cac cac ttt      672
 Val Ala Gln His Thr Ser Leu Gly Ser Leu Ile Phe Cys His His Phe
 205                 210                 215                 220

 ggg gat atc gca gca ggt ctg tgc caa ctg gga ttc tgc cca acc aaa      720
 Gly Asp Ile Ala Ala Gly Leu Cys Gln Leu Gly Phe Cys Pro Thr Lys
                 225                 230                 235

 aga aaa ctg cta aca cct gca gaa gag gtt cta act gaa gag gag aga      768
 Arg Lys Leu Leu Thr Pro Ala Glu Glu Val Leu Thr Glu Glu Glu Arg
             240                 245                 250

 acc cta tcc agg ggg gcc ttg aga gac atg ctg gat caa gtc tat cag      816
 Thr Leu Ser Arg Gly Ala Leu Arg Asp Met Leu Asp Gln Val Tyr Gln
         255                 260                 265

 ccc tta gca gtc cgg gaa ctg ctt atc ctc cag gga gga cca ccc cag      864
 Pro Leu Ala Val Arg Glu Leu Leu Ile Leu Gln Gly Gly Pro Pro Gln
     270                 275                 280

 tcc tgc aca gat gtg aag aca cag atg agg tgt cgg gcc cca gct tgg      912
 Ser Cys Thr Asp Val Lys Thr Gln Met Arg Cys Arg Ala Pro Ala Trp
 285                 290                 295                 300

 ctt cgg cgt cta tgt gga cag ctg ctc tct gaa agg tta atg aga cct      960
 Leu Arg Arg Leu Cys Gly Gln Leu Leu Ser Glu Arg Leu Met Arg Pro
                 305                 310                 315

 aat ggt gtt cag gca gta gtc cgg ggc att ttg gaa gga gca ggt gcg     1008
 Asn Gly Val Gln Ala Val Val Arg Gly Ile Leu Glu Gly Ala Gly Ala
             320                 325                 330

 gga gca gct ggt gga agt gat gct gag gtg acg gct gct gac tgg aag     1056
 Gly Ala Ala Gly Gly Ser Asp Ala Glu Val Thr Ala Ala Asp Trp Lys
         335                 340                 345

 aag tgt gac ctg atc gca aag att ttg gcc tct tgt ccc cag cag tct     1104
 Lys Cys Asp Leu Ile Ala Lys Ile Leu Ala Ser Cys Pro Gln Gln Ser
     350                 355                 360

 ctt tca cca gag aat tac tac agg gac atc tgc ccc cag gtt ctg gat     1152
 Leu Ser Pro Glu Asn Tyr Tyr Arg Asp Ile Cys Pro Gln Val Leu Asp
 365                 370                 375                 380

 tta ttt cac ttt caa gat aaa ttg aca gca cga caa ttt cag aga gtt     1200
 Leu Phe His Phe Gln Asp Lys Leu Thr Ala Arg Gln Phe Gln Arg Val
                 385                 390                 395

 gcc acc act acc ttt ata act ttg tca aga gaa cgc cca cat ttg gca     1248
 Ala Thr Thr Thr Phe Ile Thr Leu Ser Arg Glu Arg Pro His Leu Ala
             400                 405                 410

 gca aag tat ttg ctc cag cca gtg tta gct cct ctt cat cga tgt ttg     1296
 Ala Lys Tyr Leu Leu Gln Pro Val Leu Ala Pro Leu His Arg Cys Leu
         415                 420                 425

 aat aca gca gag ctt tca gag agt gac atg gta cca gga act att ttg     1344
 Asn Thr Ala Glu Leu Ser Glu Ser Asp Met Val Pro Gly Thr Ile Leu
     430                 435                 440

 gtg aca gaa gaa gaa ctt agt aga tgc att gag gat gtg ttt aag gtg     1392
 Val Thr Glu Glu Glu Leu Ser Arg Cys Ile Glu Asp Val Phe Lys Val
 445                 450                 455                 460

 tac gtg gtt ggg aat gaa cct tta aca gtt ttg atg gat tcc ctg ctt     1440
 Tyr Val Val Gly Asn Glu Pro Leu Thr Val Leu Met Asp Ser Leu Leu
                 465                 470                 475

 cca gtc ctg gga gtg ctt ttt ctt ctc tac tgt ttt act aag cag agt     1488
 Pro Val Leu Gly Val Leu Phe Leu Leu Tyr Cys Phe Thr Lys Gln Ser
             480                 485                 490

 gtg tct cac ata agg tca ctt tgc caa gaa atc tta tta tgg att ctg     1536
 Val Ser His Ile Arg Ser Leu Cys Gln Glu Ile Leu Leu Trp Ile Leu
         495                 500                 505

 ggg aag ctg gaa agg aag aag gca att gcc agc ctg aaa gga ttt gca     1584
 Gly Lys Leu Glu Arg Lys Lys Ala Ile Ala Ser Leu Lys Gly Phe Ala
     510                 515                 520

 ggg ttg gac aaa gct gtg ccc tct ctc cat tct ctg tgt cag ttt aga     1632
 Gly Leu Asp Lys Ala Val Pro Ser Leu His Ser Leu Cys Gln Phe Arg
 525                 530                 535                 540

 gtt gcc act caa ggt ggc att atg att acc atc aaa gag gcc att agt     1680
 Val Ala Thr Gln Gly Gly Ile Met Ile Thr Ile Lys Glu Ala Ile Ser
                 545                 550                 555

 gat gaa gat gaa gat gaa gcc ctg tac cag aag gta tcc tct gag cag     1728
 Asp Glu Asp Glu Asp Glu Ala Leu Tyr Gln Lys Val Ser Ser Glu Gln
             560                 565                 570

 ggc cgg gtg gag cat ctc ggg gac ttg ctg tcc cac tgc cag gaa tgc     1776
 Gly Arg Val Glu His Leu Gly Asp Leu Leu Ser His Cys Gln Glu Cys
         575                 580                 585

 ggt ttg gca gga gac ttc ttc atc ttc tgt ttg aaa gag ttg act cat     1824
 Gly Leu Ala Gly Asp Phe Phe Ile Phe Cys Leu Lys Glu Leu Thr His
     590                 595                 600

 gtg gcc tcg gaa aat gaa aca gag tta aaa act gag ccc ttc tcc agc     1872
 Val Ala Ser Glu Asn Glu Thr Glu Leu Lys Thr Glu Pro Phe Ser Ser
 605                 610                 615                 620

 aag agc ctc ttg gaa tta gag caa cat cag act ctt ctt gtg gaa ggc     1920
 Lys Ser Leu Leu Glu Leu Glu Gln His Gln Thr Leu Leu Val Glu Gly
                 625                 630                 635

 caa gag cgg aag ctg ctt gtc ctg cag ctg atg gct gtt ctg tgc gag     1968
 Gln Glu Arg Lys Leu Leu Val Leu Gln Leu Met Ala Val Leu Cys Glu
             640                 645                 650

 aga atg tct gag cag ata ttc aca aac gtc act cag gtg gtg gac ttt     2016
 Arg Met Ser Glu Gln Ile Phe Thr Asn Val Thr Gln Val Val Asp Phe
         655                 660                 665

 gta gca gca aca ttg cag aga gcc tgt gca agc ctg gcc cat cag gca     2064
 Val Ala Ala Thr Leu Gln Arg Ala Cys Ala Ser Leu Ala His Gln Ala
     670                 675                 680

 gag agc acc gtg gaa tca cag acg ctg agc atg tcc atg ggg ctg gtg     2112
 Glu Ser Thr Val Glu Ser Gln Thr Leu Ser Met Ser Met Gly Leu Val
 685                 690                 695                 700

 gct gtc atg cta gga gga gct gtt cag ttg aag tca agt gat ttt gct     2160
 Ala Val Met Leu Gly Gly Ala Val Gln Leu Lys Ser Ser Asp Phe Ala
                 705                 710                 715

 gtt ctg aag cag ttg ttg cct ctg ttg gag aag gta tcc aac aca tac     2208
 Val Leu Lys Gln Leu Leu Pro Leu Leu Glu Lys Val Ser Asn Thr Tyr
             720                 725                 730

 cct gat ccg gtc atc caa gaa ctc gct gtt gat ctc cgc atc acc atc     2256
 Pro Asp Pro Val Ile Gln Glu Leu Ala Val Asp Leu Arg Ile Thr Ile
         735                 740                 745

 tct acc cat gga gcc ttt gcc act gag gcc gtc agc atg gct gcc caa     2304
 Ser Thr His Gly Ala Phe Ala Thr Glu Ala Val Ser Met Ala Ala Gln
     750                 755                 760

 agt aca ctg aac aga aaa gat ctg gaa ggg aaa ata gaa gag cag caa     2352
 Ser Thr Leu Asn Arg Lys Asp Leu Glu Gly Lys Ile Glu Glu Gln Gln
 765                 770                 775                 780

 caa acc agt cat gaa aga ccc act gat gta gct cat agc cac ctt gaa     2400
 Gln Thr Ser His Glu Arg Pro Thr Asp Val Ala His Ser His Leu Glu
                 785                 790                 795

 caa cag cag agc cat gag aca gcc ccc cag aca ggc ctg cag tca aat     2448
 Gln Gln Gln Ser His Glu Thr Ala Pro Gln Thr Gly Leu Gln Ser Asn
             800                 805                 810

 gct cca atc att cct caa gga gtc aat gag ccc agc act act aca agt     2496
 Ala Pro Ile Ile Pro Gln Gly Val Asn Glu Pro Ser Thr Thr Thr Ser
         815                 820                 825

 cag aaa tct gga agc gta acc aca gaa cag ctc caa gag gtt ctt ttg     2544
 Gln Lys Ser Gly Ser Val Thr Thr Glu Gln Leu Gln Glu Val Leu Leu
     830                 835                 840

 tca gct tat gac cct caa att cca aca cgg gct gct gcc ctg cgt act     2592
 Ser Ala Tyr Asp Pro Gln Ile Pro Thr Arg Ala Ala Ala Leu Arg Thr
 845                 850                 855                 860

 ctt tcc cac tgg ata gag cag aga gaa gca aaa gcc ctt gag atg caa     2640
 Leu Ser His Trp Ile Glu Gln Arg Glu Ala Lys Ala Leu Glu Met Gln
                 865                 870                 875

 gag aag ctt ctc aag ata ttc ttg gaa aac ttg gaa cat gaa gac act     2688
 Glu Lys Leu Leu Lys Ile Phe Leu Glu Asn Leu Glu His Glu Asp Thr
             880                 885                 890

 ttt gta tat cta tct gca att cag ggg gtt gcc ctg ctg tca gac gtc     2736
 Phe Val Tyr Leu Ser Ala Ile Gln Gly Val Ala Leu Leu Ser Asp Val
         895                 900                 905

 tat cct gag aaa atc ttg ccg gac ttg ttg gct caa tat gac agc agc     2784
 Tyr Pro Glu Lys Ile Leu Pro Asp Leu Leu Ala Gln Tyr Asp Ser Ser
     910                 915                 920

 aaa gac aag cac aca cca gag acc aga atg aaa gtc ggg gaa gtc ctt     2832
 Lys Asp Lys His Thr Pro Glu Thr Arg Met Lys Val Gly Glu Val Leu
 925                 930                 935                 940

 atg cga atc gtc agg gca tta gga gac atg gtc tca aag tac cga gaa     2880
 Met Arg Ile Val Arg Ala Leu Gly Asp Met Val Ser Lys Tyr Arg Glu
                 945                 950                 955

 cct ttg atc cat acc ttc ctg agg gga gtg aga gat cct gat ggt gct     2928
 Pro Leu Ile His Thr Phe Leu Arg Gly Val Arg Asp Pro Asp Gly Ala
             960                 965                 970

 cac agg gcc agc agc ttg gcc aac ctt ggg gag ctg tgc cag agg ctg     2976
 His Arg Ala Ser Ser Leu Ala Asn Leu Gly Glu Leu Cys Gln Arg Leu
         975                 980                 985

 gac ttt ctg ctg ggc tcc gtg gtc cat gag gta aca gct tgc ctg att     3024
 Asp Phe Leu Leu Gly Ser Val Val His Glu Val Thr Ala Cys Leu Ile
     990                 995                1000

 gct gtg gcc aaa aca gat ggt gaa gtt caa gta cgc aga gct gcc ata     3072
 Ala Val Ala Lys Thr Asp Gly Glu Val Gln Val Arg Arg Ala Ala Ile
1005                1010                1015                1020

 cat gtg gtt gtg ctg ctg ctt cgg gga ctc agc cag aaa gct act gag     3120
 His Val Val Val Leu Leu Leu Arg Gly Leu Ser Gln Lys Ala Thr Glu
                1025                1030                1035

 gtg ctg agc gcc gtc ctc aag gat ctc tac cac ctg ctg aag cac gta     3168
 Val Leu Ser Ala Val Leu Lys Asp Leu Tyr His Leu Leu Lys His Val
            1040                1045                1050

 gtg tgt ctg gag ccc gat gac gtg gcc aag ctc cat gcc cag ttg gcc     3216
 Val Cys Leu Glu Pro Asp Asp Val Ala Lys Leu His Ala Gln Leu Ala
        1055                1060                1065

 cta gaa gag ctg gat gac atc atg aaa aac ttc ctg ttc cct cca cag     3264
 Leu Glu Glu Leu Asp Asp Ile Met Lys Asn Phe Leu Phe Pro Pro Gln
    1070                1075                1080

 aag ctg gag aag aag atc atg gtc ctg ccg tag acctggct ccaaggacgt     3315
 Lys Leu Glu Lys Lys Ile Met Val Leu Pro 
1085                1090

 ggaggaggca ggcagggcca ggcacccaga gccgtgccca ggtcttccag caggtggccc   3375

 tgctgcctct tgagtgctgg cagcatggct gaccctcggg gtggttttat ggtgcaggtc   3435

 acttgggtct tcagggtccc ttccgagggc atgtgttcag cactcccgcg ttcagcctga   3495

 ggggtgtaca gttaagagaa gacagttaca gatctcatta atctacattt ttcactgtcc   3555

 tctagcattg aaagaaggat gtctacctgg tgaaagtata ttttaacatg actgatggaa   3615

 tttcactaat tgcccactct cttggaactt gaggagaagc ggttggccac ccatatgtca   3675

 cctagctcta tattctttca ggctgagatt cttcttcagg aaaatgagga gcagaactgg   3735

 ccacccttgg ctgctcaaga ggcatttcag agtaggagat gcagttggag gtggggaggg   3795

 gaaggaaata gttatcaaat aatgcaaaat ggaataaagt tatcttggat gaaagancag   3855

 gnnctaatct ggtctctggt gtcgagatgg aaaactgttg ngagttgaag aggctctgat   3915

 gcccagaaag gacaatcaag ctggttgact ctttccagag aagaagggta agccctgtat   3975

 ttatcctccc aggccattct tcttcactcc tgctgctgtt tgcagagagt tgccctgatt   4035

 atcaggagaa aagaaccacg agcatccaga gagtttacat cctgccttct gtcctctgct   4095

 ccttcagaaa gatgaatgcc tagacaatgg gttcacactg aatgcaggct ggaaagaatg   4155

 catgctggtg gcctaatgcc agggctgttg aaacaatttc agatatagca aaaaaaaaa    4214




      <210> 606
      <211> 1058
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (318)..(1058)

      <400> 606
 ctgggtggct gccaagtggg ctaggtaggc accagagggt ctggttggca ctcgcgtgat     60

 ggagacaagg ggacggatga gcgacagggt gtcagggcat ccagatggct caggtatccg    120

 acacctgggc ccagagtcac atgccaggaa acccaacact cttgggtccc agcccccaac    180

 ttccagcagc tacgagcaaa cagggcttct ggaggaggaa gcgggtctcc agagcccagc    240

 agcagggagc ctacgtccag ggacagggca tctgcactgg agaaggctct gccaccaaca    300

 ggggactatg ccaattt   atg gcc atg ctc cca aca gca ggt cac ctc ctg     350
                      Met Ala Met Leu Pro Thr Ala Gly His Leu Leu
                        1               5                  10

 ccc ctc ctg ctg gtg ata ggc aca ggg ggt act gtg ccc agc ccc cag      398
 Pro Leu Leu Leu Val Ile Gly Thr Gly Gly Thr Val Pro Ser Pro Gln
              15                  20                  25

 gtg cct ccc cgg ggc tgt tat gtg gca aag gaa gca ggt gaa cgg acg      446
 Val Pro Pro Arg Gly Cys Tyr Val Ala Lys Glu Ala Gly Glu Arg Thr
          30                  35                  40

 ttc cgc tgc agc cag gca ggc ctc agt gct gtg ccc tcc ggc atc ccc      494
 Phe Arg Cys Ser Gln Ala Gly Leu Ser Ala Val Pro Ser Gly Ile Pro
      45                  50                  55

 aat gac acc cgc aag ctc tac ctg gat gcc aac cag ctg gca tcg gtg      542
 Asn Asp Thr Arg Lys Leu Tyr Leu Asp Ala Asn Gln Leu Ala Ser Val
  60                  65                  70                  75

 cct gct ggt gcc ttc cag cac ctg cct gtc ctg gag gag ttg gat ctg      590
 Pro Ala Gly Ala Phe Gln His Leu Pro Val Leu Glu Glu Leu Asp Leu
                  80                  85                  90

 tcc cat aat gcc ctt gcc cac ctc tca ggg gcg gct ttc cag ggc ctg      638
 Ser His Asn Ala Leu Ala His Leu Ser Gly Ala Ala Phe Gln Gly Leu
              95                 100                 105

 gag ggc aca ttg cgc cac ctc gac ctc tct gcc aac cag ctg gcc tca      686
 Glu Gly Thr Leu Arg His Leu Asp Leu Ser Ala Asn Gln Leu Ala Ser
         110                 115                 120

 atc caa gtg aac cta tcc gca aac cca tgg cac tgt gac tgc gcc ctc      734
 Ile Gln Val Asn Leu Ser Ala Asn Pro Trp His Cys Asp Cys Ala Leu
     125                 130                 135

 cag gaa gtg ctc cgg cag gtg agg ctg gtg ccg ggc act ggg aca ggc      782
 Gln Glu Val Leu Arg Gln Val Arg Leu Val Pro Gly Thr Gly Thr Gly
 140                 145                 150                 155

 atc gtg tgt ggc tca gga gcc cga ccg gac ctc gtg ggg cag gag ttc      830
 Ile Val Cys Gly Ser Gly Ala Arg Pro Asp Leu Val Gly Gln Glu Phe
                 160                 165                 170

 ctg ctg ctg gca ggg gag gaa gag ctg tgt ggg tcg ggg tgg ggt ggg      878
 Leu Leu Leu Ala Gly Glu Glu Glu Leu Cys Gly Ser Gly Trp Gly Gly
             175                 180                 185

 gcc cgg agg agc acc gat gtg gcc ctg ctg gtc acc atg ggg ggc tgg      926
 Ala Arg Arg Ser Thr Asp Val Ala Leu Leu Val Thr Met Gly Gly Trp
         190                 195                 200

 ctg aca ctc atg gtg gct tat ctg gtg cat tat gtg tgg cag aac cga      974
 Leu Thr Leu Met Val Ala Tyr Leu Val His Tyr Val Trp Gln Asn Arg
     205                 210                 215

 gat gag acc agg cgc tcc ctc aag cgg gcc cca gtg ctg ccc gtg cgt     1022
 Asp Glu Thr Arg Arg Ser Leu Lys Arg Ala Pro Val Leu Pro Val Arg
 220                 225                 230                 235

 tcc gag gac tcc tcc atc ctc agc aca gtg gtc tga                     1058
 Ser Glu Asp Ser Ser Ile Leu Ser Thr Val Val 
                 240                 245





      <210> 607
      <211> 4702
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1333)..(2943)

      <220>
      <221> misc_feature
      <222> (1)...(4702)
      <223> n = a,t,c or g

      <400> 607
 atggacatcc tgagggtgag gggagaaggc aggcaaggtg ctggcaccac acttctgctg     60

 ggattgtgca cggtttggca tcctggttcc aagctgagcc ccctgcagtt gcagaaggcc    120

 actttgcaaa gggcagccat ggagcccaag accggacacc tccccactga aaagcagctc    180

 cacttaggag ggcccaaggt tctcgtgtat actgttccca gtgcgcagtg tgatttggta    240

 tggcgtggga agcagggagc agggaaagtg gcctggactt cctgccctgg ctgtcagccg    300

 ccagccagcc ctgattcgga gactgtttac ccccgagtgg atgatggcag cctggccaag    360

 gagcatccgg tgcccaccta tacaagaggc cactccgtcg agtggacgga ggtagacacc    420

 ggctctcagc agcagcgacg tcgtactggc tctgtgctag gctccatccg ggcatctgtc    480

 tctcggctgt cctctggggg ctgtgtccac atcagccaga ccctgagtgg ggagtacagc    540

 cctccaagtg cctctggctg ctgcctgggg acagaagtcc ctccagagag tttggacttg    600

 aatcttgagc tctcagccac tctgttctgc gatcactatc ctcgtttcac gtgtgagaga    660

 aaacggaggc tccaacagga ctgtcctggg gccttcactg catggcctga acaggggctg    720

 ggctcccagg gaggaatgat tcatggctgg ttcccgccct atagacaaga cagtcacaag    780

 gagctggcag gcctggcgga cgagcccggc ggcggagatg ggggcgacgg gggcggcgga    840

 gccgctgcaa tccgtgctgt gggtgaagca gcagcgctgc gccgtgagcc tggagcccgc    900

 gcgggctctg ctgcgctggt ggcggagccc ggggcccgga gccggcgccc ccggcgcggc    960

 ctcaccaagg cccagccctc cttcccagac tcacctagca ctggttattt tgcagtatgt   1020

 tccaagactg ggcagcgttt acaccttctg tttagctggt ttctctggca ctgctccagc   1080

 agggaacggc gctggtactg ccaggggcct gcacccaccc tgctgcccca tagctcagac   1140

 gtccccgagg ccagagctgg agataaaccc agctcccagc tgctgactct gcacgctggc   1200

 ctctccagcc agcgggcctg ctgctgtgga tctctggtgt ccccggttca ctgcctgttt   1260

 cttgtatctt gtccagagct atcagtcata gcgggacggg aggctgatgc aggtttcccg   1320

 cgacctgaca gc    atg gag tgg gga cgg cgg gtg ttc tgt gtt gag atg    1368
                  Met Glu Trp Gly Arg Arg Val Phe Cys Val Glu Met
                    1               5                  10

 cca gct gaa gga cgt ggt gtt ttt aca gat gcc tgc tct gtg cct gta     1416
 Pro Ala Glu Gly Arg Gly Val Phe Thr Asp Ala Cys Ser Val Pro Val
          15                  20                  25

 tct gag atc atc gcc gtt gag gaa aca gac gtt cac ggg aaa cat caa     1464
 Ser Glu Ile Ile Ala Val Glu Glu Thr Asp Val His Gly Lys His Gln
      30                  35                  40

 ggc agt gga aaa tgg cag aaa atg gaa aag cct tac gct ttt aca gtt     1512
 Gly Ser Gly Lys Trp Gln Lys Met Glu Lys Pro Tyr Ala Phe Thr Val
  45                  50                  55                  60

 cac tgt gta aag aga gca cga cgg cac cgc tgg aag tgg gcg cag gtg     1560
 His Cys Val Lys Arg Ala Arg Arg His Arg Trp Lys Trp Ala Gln Val
                  65                  70                  75

 act ttc tgg tgt cca gag gag cag ctg tgt cac ttg tgg ctg cag acc     1608
 Thr Phe Trp Cys Pro Glu Glu Gln Leu Cys His Leu Trp Leu Gln Thr
              80                  85                  90

 ctg cgg gag atg ctg gag aag ctg att act gaa cat gct aat cag gcc     1656
 Leu Arg Glu Met Leu Glu Lys Leu Ile Thr Glu His Ala Asn Gln Ala
          95                 100                 105

 aag gag act ctg tat gag att aac ata gac aaa tac gac ggc atc gtc     1704
 Lys Glu Thr Leu Tyr Glu Ile Asn Ile Asp Lys Tyr Asp Gly Ile Val
     110                 115                 120

 tgt gtc ggc gga gat ggt atg ttc agc gag gtg ctg cac ggt ctg att     1752
 Cys Val Gly Gly Asp Gly Met Phe Ser Glu Val Leu His Gly Leu Ile
 125                 130                 135                 140

 ggg agg acg cag agg agc gcc ggg gtc gac cag aac cac ccc cgg gct     1800
 Gly Arg Thr Gln Arg Ser Ala Gly Val Asp Gln Asn His Pro Arg Ala
                 145                 150                 155

 gtg ctg gtc ccc agt agc ctc cgg att gga atc att ccc gca ggc ttt     1848
 Val Leu Val Pro Ser Ser Leu Arg Ile Gly Ile Ile Pro Ala Gly Phe
             160                 165                 170

 gca aat gac ctg gca ggg gac gag gtg tct gtc ctc tct ggc cct gtg     1896
 Ala Asn Asp Leu Ala Gly Asp Glu Val Ser Val Leu Ser Gly Pro Val
         175                 180                 185

 tct ggc ccc gag ggt ggc ggc atg gtg cac act ttc act ctc gtc aca     1944
 Ser Gly Pro Glu Gly Gly Gly Met Val His Thr Phe Thr Leu Val Thr
     190                 195                 200

 gct ctg gga tgt gag cac cgc agt cat ccc cat ttt atg gat gaa gac     1992
 Ala Leu Gly Cys Glu His Arg Ser His Pro His Phe Met Asp Glu Asp
 205                 210                 215                 220

 agg agg act ggg gag cat gtg ggc ccc ggt gag aac gct ggt ggc ttg     2040
 Arg Arg Thr Gly Glu His Val Gly Pro Gly Glu Asn Ala Gly Gly Leu
                 225                 230                 235

 gac ggg tca acg gac tgc gtg tgt tac tcc acc gtg ggc acc agc gac     2088
 Asp Gly Ser Thr Asp Cys Val Cys Tyr Ser Thr Val Gly Thr Ser Asp
             240                 245                 250

 gca gaa acc tcg gcg ctg cat atc gtt gtt ggg gac tcg ctg gcc atg     2136
 Ala Glu Thr Ser Ala Leu His Ile Val Val Gly Asp Ser Leu Ala Met
         255                 260                 265

 gat gtg tcc tca gtc cac cac aac agc aca ctc ctt cgc tac tcc gtg     2184
 Asp Val Ser Ser Val His His Asn Ser Thr Leu Leu Arg Tyr Ser Val
     270                 275                 280

 tcc ctg ctg ggc tac ggc ttc tac ggg gac atc atc aag gac agt gag     2232
 Ser Leu Leu Gly Tyr Gly Phe Tyr Gly Asp Ile Ile Lys Asp Ser Glu
 285                 290                 295                 300

 aag aaa cgg tgg ttg ggt ctt gcc aga tac gac ttt tca ggt tta aag     2280
 Lys Lys Arg Trp Leu Gly Leu Ala Arg Tyr Asp Phe Ser Gly Leu Lys
                 305                 310                 315

 acc ttc ctc tcc cac cac tgc tat gaa ggg aca gtg tcc ttc ctc cct     2328
 Thr Phe Leu Ser His His Cys Tyr Glu Gly Thr Val Ser Phe Leu Pro
             320                 325                 330

 gca caa cac acg gtg gga tct cca agg gat agg aag ccc tgc cgg gca     2376
 Ala Gln His Thr Val Gly Ser Pro Arg Asp Arg Lys Pro Cys Arg Ala
         335                 340                 345

 gga tgc ttt gtt tgc agg caa agc aag cag cag ctg gag gag gag cag     2424
 Gly Cys Phe Val Cys Arg Gln Ser Lys Gln Gln Leu Glu Glu Glu Gln
     350                 355                 360

 aag aaa gca ctg tat ggt ttg gaa gct gcg gag gac gtg gag gag tgg     2472
 Lys Lys Ala Leu Tyr Gly Leu Glu Ala Ala Glu Asp Val Glu Glu Trp
 365                 370                 375                 380

 caa gtc gtc tgt ggg aag ttt ctg gcc atc aat gcc aca aac atg tcc     2520
 Gln Val Val Cys Gly Lys Phe Leu Ala Ile Asn Ala Thr Asn Met Ser
                 385                 390                 395

 tgt gct tgt cgc cgg agc ccc agg ggc ctc tcc ccg gct gcc cac ttg     2568
 Cys Ala Cys Arg Arg Ser Pro Arg Gly Leu Ser Pro Ala Ala His Leu
             400                 405                 410

 gga gac ggg tct tct gac ctc atc ctc atc cgg aaa tgc tcc agg ttc     2616
 Gly Asp Gly Ser Ser Asp Leu Ile Leu Ile Arg Lys Cys Ser Arg Phe
         415                 420                 425

 aat ttt ctg aga ttt ctc atc agg cac acc aac cag cag gac cag ttt     2664
 Asn Phe Leu Arg Phe Leu Ile Arg His Thr Asn Gln Gln Asp Gln Phe
     430                 435                 440

 gac ttc act ttt gtt gaa gtt tat cgc gtc aag aaa ttc cag ttt acg     2712
 Asp Phe Thr Phe Val Glu Val Tyr Arg Val Lys Lys Phe Gln Phe Thr
 445                 450                 455                 460

 tcg aag cac atg gag gat gag gac agc gac ctc aag gag ggg ggg aag     2760
 Ser Lys His Met Glu Asp Glu Asp Ser Asp Leu Lys Glu Gly Gly Lys
                 465                 470                 475

 aag cgc ttt ggg cac att tgc agc agc cac ccc tcc tgc tgc tgc acc     2808
 Lys Arg Phe Gly His Ile Cys Ser Ser His Pro Ser Cys Cys Cys Thr
             480                 485                 490

 gtc tcc aac agc tcc tgg aac tgc gac ggg gag gtc ctg cac agc cct     2856
 Val Ser Asn Ser Ser Trp Asn Cys Asp Gly Glu Val Leu His Ser Pro
         495                 500                 505

 gcc atc gag gtc aga gtc cac tgc cag ctg gtt cga ctc ttt gca cga     2904
 Ala Ile Glu Val Arg Val His Cys Gln Leu Val Arg Leu Phe Ala Arg
     510                 515                 520

 gga att gaa gag aat ccg aag cca gac tca cac agc tga gaagccggcg      2953
 Gly Ile Glu Glu Asn Pro Lys Pro Asp Ser His Ser 
 525                 530                 535

 tcctgctctc gaactgggaa agtgtgaaaa ctatttaaga taattattac agaccaatta   3013

 tgttgatata tacatttaaa tgtagaaatt tatttttgat agttaaatct tgattttann   3073

 nnnnnnnnnn nnnnnnnnnn nntttgtgta catatttggc attttcagtt ctgtacgcat   3133

 ctgcgggttg cagcccacgc cgcttactct cagcggatgc agctgctcac ttgggggcac   3193

 tggcctctta ggttttaacg atgtcaacag tgtagtttag aaaatggccc gttagtggct   3253

 ctattgcaat aatgttaggg acattatatg atttccacgc aggtcacacc atctgggcct   3313

 gaggtagcag tgggtcactt tgatccactt tgcaggactt attctgtaac ggtttgtggc   3373

 caagttttgg gaagtggttg attctctttg ccttcatttc accttcctct tcgtttacgg   3433

 ttaggacatc gctgcttgat ccttacaata ctgtgcaact gcaatgcaac gtggccctgc   3493

 ttcaggtgat ccgcgggagg ggcctccacg ccagcgccgg gaaggctgct ggggcctcca   3553

 cacctgcctc atcacggcgg cgaggctacg acaatccggc tgggagcatg accttggcgt   3613

 ctgttctggg agcacagatg ataagctctg gaagctggca gtgtgtaaag cactggcaag   3673

 tttgttactg ttaaaatgtc aaataccaat gctttatatc gacgcgaagt gcttaacaca   3733

 gccgggcttg ggggcagtca ggaggaagct ggccatccgt ggaggagggg ccggtcctgg   3793

 actcccgcag gactcctctg atgcagggcc tgaagtctgt acacgtggtc cagatttgtc   3853

 cttgtctttt cttcacactg agttctctat atttattgaa catcttgtcc ttttaagcca   3913

 gagtagtgta aactgcgtct cggatgtctg tcttttgcct cgaagccacg atggatcgct   3973

 ggtttcctct gcagcgcgag ggctccggcg accagaggat tcttcccgga aggcattcct   4033

 gccgcgctcc ccggggcacc cctcaattgt gtactacgtc cttgtttagt gtgtatccgt   4093

 gcccacgtag atgatgtctg taacgtagtt ttgtttgaaa tatgagaata tgcggcttaa   4153

 actttgatct gtaaggagcg gggccgtggc cgtttggagc acgctgtaga caccgttcct   4213

 catgctgccg ggtgggtttt gcagaagctc ccttagtgat ttcatgttta acaggcagca   4273

 tccattttca gaatttcctg gcattgattt atattttgaa gcatacagga aacttctcgt   4333

 ttcctcgttt agccccaccc agatcaggtg aaagggcagc tttaatggtg gtttttatgg   4393

 accacattat cagagagcac tgtgcaagcc aaatggttca ataatgaatg aaaattctgg   4453

 gtgtaaagag taaatatgcc ctggctcttt ctaccaatgt ttgctcctgg ttggaaagaa   4513

 accaaagatt taagacgggc tgctcttcca gactggctgt gcctgcctgt gcccagcaac   4573

 ctgtgcagcc ggcagtgtgc ctggtgtcac gccaggaggc tgtggctgct gtgggccctc   4633

 tggaattgtg ctcctcacaa agtttcccca aaaggttctt ctaagccttt attgtccctg   4693

 gtaaatgtt                                                           4702




      <210> 608
      <211> 1245
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (335)..(1147)

      <400> 608
 cagatcctca tctccctggg tagtgaggct cagcacagac aagcaaccaa ctgctgggct     60

 gccggtgccc cccatgttgg aacctgagtt ggagattatc tcctaagcag atacctgctt    120

 ccaaactggg gatgtagggc ttggaaacta gaaaatgcca ggtctgaggg agaggaaaga    180

 acaagtccag caatacacag agctctgtgt attcagaggg aagttggcag ggttgtgttc    240

 gggcagagaa actccgagtg gtacaaaggg gacgtgccca gagtggagaa atcatgctaa    300

 ttgtctgcac tagagctgga gaacgccacc caaa    atg aag aga gaa agg gga     352
                                          Met Lys Arg Glu Arg Gly
                                            1               5

 gcc ctg tcc aga gcc tcc agg gcc ctg cgc ctt gct cct ttt gtc tac      400
 Ala Leu Ser Arg Ala Ser Arg Ala Leu Arg Leu Ala Pro Phe Val Tyr
              10                  15                  20

 ctt ctt ctg atc cag aca gac ccc ctg gag ggg gtg aac atc acc agc      448
 Leu Leu Leu Ile Gln Thr Asp Pro Leu Glu Gly Val Asn Ile Thr Ser
          25                  30                  35

 ccc gtg cgc ctg atc cat ggc acc gtg ggg aag tcg gct ctg ctt tct      496
 Pro Val Arg Leu Ile His Gly Thr Val Gly Lys Ser Ala Leu Leu Ser
      40                  45                  50

 gtg cag tac agc agt acc agc agc gac agg cct gta gtg aag tgg cag      544
 Val Gln Tyr Ser Ser Thr Ser Ser Asp Arg Pro Val Val Lys Trp Gln
  55                  60                  65                  70

 ctg aag cgg gac aag cca gtg acc gtg gtg cag tcc att ggc aca gag      592
 Leu Lys Arg Asp Lys Pro Val Thr Val Val Gln Ser Ile Gly Thr Glu
                  75                  80                  85

 gtc atc ggc acc ctg cgg cct gac tat cga gac cgt atc cga ctc ttt      640
 Val Ile Gly Thr Leu Arg Pro Asp Tyr Arg Asp Arg Ile Arg Leu Phe
              90                  95                 100

 gaa aat ggc tcc ctg ctt ctc agc gac ctg cag ctg gcc gat gag ggc      688
 Glu Asn Gly Ser Leu Leu Leu Ser Asp Leu Gln Leu Ala Asp Glu Gly
         105                 110                 115

 acc tat gag gtc gag atc tcc atc acc gac gac acc ttc act ggg gag      736
 Thr Tyr Glu Val Glu Ile Ser Ile Thr Asp Asp Thr Phe Thr Gly Glu
     120                 125                 130

 aag acc atc aac ctt act gta gat gtg ccc att tcg agg cca cag gtg      784
 Lys Thr Ile Asn Leu Thr Val Asp Val Pro Ile Ser Arg Pro Gln Val
 135                 140                 145                 150

 ttg gtg gct tca acc act gtg ctg gag ctc agc gag gcc ttc acc ttg      832
 Leu Val Ala Ser Thr Thr Val Leu Glu Leu Ser Glu Ala Phe Thr Leu
                 155                 160                 165

 aac tgc tca cat gag aat ggc acc aag ccc agc tac acc tgg ctg aag      880
 Asn Cys Ser His Glu Asn Gly Thr Lys Pro Ser Tyr Thr Trp Leu Lys
             170                 175                 180

 gat ggc aag ccc ctc ctc aat gac tcg aga atg ctc ctg tcc ccc gac      928
 Asp Gly Lys Pro Leu Leu Asn Asp Ser Arg Met Leu Leu Ser Pro Asp
         185                 190                 195

 caa aag gtg ctc acc atc acc cgc gtg ctc atg gag gat gac gac ctg      976
 Gln Lys Val Leu Thr Ile Thr Arg Val Leu Met Glu Asp Asp Asp Leu
     200                 205                 210

 tac agc tgc atg gtg gag aac ccc atc agc cag ggc cgc agc ctg cct     1024
 Tyr Ser Cys Met Val Glu Asn Pro Ile Ser Gln Gly Arg Ser Leu Pro
 215                 220                 225                 230

 gtc aag atc acc gta tac aga aga agc tcc ctt tac atc atc ttg tct     1072
 Val Lys Ile Thr Val Tyr Arg Arg Ser Ser Leu Tyr Ile Ile Leu Ser
                 235                 240                 245

 aca gga ggc atc ttc ctc ctt gtg acc ttg gtg aca gtc tgt gcc tgc     1120
 Thr Gly Gly Ile Phe Leu Leu Val Thr Leu Val Thr Val Cys Ala Cys
             250                 255                 260

 tgg aaa ccc tcc aaa agg tct ggg taa ctctc atgagcacct gagtccttca     1172
 Trp Lys Pro Ser Lys Arg Ser Gly 
         265                 270

 atccatccca aacataagcc ccattataat cttaagtctc tttaaatgcc tttcctccca   1232

 gggtgtgtgt att                                                      1245




      <210> 609
      <211> 1962
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (335)..(1585)

      <400> 609
 cagatcctca tctccctggg tagtgaggct cagcacagac aagcaaccaa ctgctgggct     60

 gccggtgccc cccatgttgg aacctgagtt ggagattatc tcctaagcag atacctgctt    120

 ccaaactggg gatgtagggc ttggaaacta gaaaatgcca ggtctgaggg agaggaaaga    180

 acaagtccag caatacacag agctctgtgt attcagaggg aagttggcag ggttgtgttc    240

 gggcagagaa actccgagtg gtacaaaggg gacgtgccca gagtggagaa atcatgctaa    300

 ttgtctgcac tagagctgga gaacgccacc caaa    atg aag aga gaa agg gga     352
                                          Met Lys Arg Glu Arg Gly
                                            1               5

 gcc ctg tcc aga gcc tcc agg gcc ctg cgc ctt gct cct ttt gtc tac      400
 Ala Leu Ser Arg Ala Ser Arg Ala Leu Arg Leu Ala Pro Phe Val Tyr
              10                  15                  20

 ctt ctt ctg atc cag aca gac ccc ctg gag ggg gtg aac atc acc agc      448
 Leu Leu Leu Ile Gln Thr Asp Pro Leu Glu Gly Val Asn Ile Thr Ser
          25                  30                  35

 ccc gtg cgc ctg atc cat ggc acc gtg ggg aag tcg gct ctg ctt tct      496
 Pro Val Arg Leu Ile His Gly Thr Val Gly Lys Ser Ala Leu Leu Ser
      40                  45                  50

 gtg cag tac agc agt acc agc agc gac agg cct gta gtg aag tgg cag      544
 Val Gln Tyr Ser Ser Thr Ser Ser Asp Arg Pro Val Val Lys Trp Gln
  55                  60                  65                  70

 ctg aag cgg gac aag cca gtg acc gtg gtg cag tcc att ggc aca gag      592
 Leu Lys Arg Asp Lys Pro Val Thr Val Val Gln Ser Ile Gly Thr Glu
                  75                  80                  85

 gtc atc ggc acc ctg cgg cct gac tat cga gac cgt atc cga ctc ttt      640
 Val Ile Gly Thr Leu Arg Pro Asp Tyr Arg Asp Arg Ile Arg Leu Phe
              90                  95                 100

 gaa aat ggc tcc ctg ctt ctc agc gac ctg cag ctg gcc gat gag ggc      688
 Glu Asn Gly Ser Leu Leu Leu Ser Asp Leu Gln Leu Ala Asp Glu Gly
         105                 110                 115

 acc tat gag gtc gag atc tcc atc acc gac gac acc ttc act ggg gag      736
 Thr Tyr Glu Val Glu Ile Ser Ile Thr Asp Asp Thr Phe Thr Gly Glu
     120                 125                 130

 aag acc atc aac ctt act gta gat gtg ccc att tcg agg cca cag gtg      784
 Lys Thr Ile Asn Leu Thr Val Asp Val Pro Ile Ser Arg Pro Gln Val
 135                 140                 145                 150

 ttg gtg gct tca acc act gtg ctg gag ctc agc gag gcc ttc acc ttg      832
 Leu Val Ala Ser Thr Thr Val Leu Glu Leu Ser Glu Ala Phe Thr Leu
                 155                 160                 165

 aac tgc tca cat gag aat ggc acc aag ccc agc tac acc tgg ctg aag      880
 Asn Cys Ser His Glu Asn Gly Thr Lys Pro Ser Tyr Thr Trp Leu Lys
             170                 175                 180

 gat ggc aag ccc ctc ctc aat gac tcg aga atg ctc ctg tcc ccc gac      928
 Asp Gly Lys Pro Leu Leu Asn Asp Ser Arg Met Leu Leu Ser Pro Asp
         185                 190                 195

 caa aag gtg ctc acc atc acc cgc gtg ctc atg gag gat gac gac ctg      976
 Gln Lys Val Leu Thr Ile Thr Arg Val Leu Met Glu Asp Asp Asp Leu
     200                 205                 210

 tac agc tgc atg gtg gag aac ccc atc agc cag ggc cgc agc ctg cct     1024
 Tyr Ser Cys Met Val Glu Asn Pro Ile Ser Gln Gly Arg Ser Leu Pro
 215                 220                 225                 230

 gtc aag atc acc gta tac aga aga agc tcc ctt tac atc atc ttg tct     1072
 Val Lys Ile Thr Val Tyr Arg Arg Ser Ser Leu Tyr Ile Ile Leu Ser
                 235                 240                 245

 aca gga ggc atc ttc ctc ctt gtg acc ttg gtg aca gtc tgt gcc tgc     1120
 Thr Gly Gly Ile Phe Leu Leu Val Thr Leu Val Thr Val Cys Ala Cys
             250                 255                 260

 tgg aaa ccc tcc aaa agg aaa cag aag aag cta gaa aag caa aac tcc     1168
 Trp Lys Pro Ser Lys Arg Lys Gln Lys Lys Leu Glu Lys Gln Asn Ser
         265                 270                 275

 ctg gaa tac atg gat cag aat gat gac cgc ctg aaa cca gaa gca gac     1216
 Leu Glu Tyr Met Asp Gln Asn Asp Asp Arg Leu Lys Pro Glu Ala Asp
     280                 285                 290

 acc ctc cct cga agt ggt gag cag gaa cgg aag aac ccc atg gca ctc     1264
 Thr Leu Pro Arg Ser Gly Glu Gln Glu Arg Lys Asn Pro Met Ala Leu
 295                 300                 305                 310

 tat atc ctg aag gac aag gac tcc ccg gag acc gag gag aac ccg gcc     1312
 Tyr Ile Leu Lys Asp Lys Asp Ser Pro Glu Thr Glu Glu Asn Pro Ala
                 315                 320                 325

 ccg gag cct cga agc gcg acg gag ccc ggc ccg ccc ggc tac tcc gtg     1360
 Pro Glu Pro Arg Ser Ala Thr Glu Pro Gly Pro Pro Gly Tyr Ser Val
             330                 335                 340

 tct ccc gcc gtg ccc ggc cgc tcg ccg ggg ctg ccc atc cgc tct gcc     1408
 Ser Pro Ala Val Pro Gly Arg Ser Pro Gly Leu Pro Ile Arg Ser Ala
         345                 350                 355

 cgc cgc tac ccg cgc tcc cca gcg cgc tcc cca gcc acc ggc cgg aca     1456
 Arg Arg Tyr Pro Arg Ser Pro Ala Arg Ser Pro Ala Thr Gly Arg Thr
     360                 365                 370

 cac tcg tcg ccg ccc agg gcc ccg agc tcg ccc ggc cgc tcg cgc agc     1504
 His Ser Ser Pro Pro Arg Ala Pro Ser Ser Pro Gly Arg Ser Arg Ser
 375                 380                 385                 390

 gcc tcg cgc aca ctg cgg act gcg ggc gtg cac ata atc cgc gag caa     1552
 Ala Ser Arg Thr Leu Arg Thr Ala Gly Val His Ile Ile Arg Glu Gln
                 395                 400                 405

 gac gag gcc ggc ccg gtg gag atc agc gcc tga gccgcctc gggatcccct     1603
 Asp Glu Ala Gly Pro Val Glu Ile Ser Ala 
             410                 415

 gagaggcgcc cgcggtctgc ggccagtggc ccgggggaaa gctggggctg ggaagcccgg   1663

 gcgcggcgcg ctggggacga ggggaggtcc cgggggggcg ctggtgtctc gggtgtgaac   1723

 gtgtatgagc atgcgcagac ggaggcgggt gcgcggaggc ggcagtgttg atatggtgaa   1783

 accgggtcgc atttgcttcc ggtttactgg ctgtgtcctc acttggtata ggttgtgccc   1843

 tcttaggacc acatagatta ttacatttct ggcccaatac ccaaaagggt tttatggaaa   1903

 ctaacatcag taacctaacc cccgtgacta tcctgtgctc aaccaaaaaa aaaaaaaaa    1962




      <210> 610
      <211> 2151
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (316)..(1470)

      <400> 610
 cgcgcgcagc cccgcacctc cgcccctgcc tctgcctcct gggccatgcc ctgctgttta     60

 catgccggtg aggtccccgg ccgctccgaa cccctccgag ccccggctcc ccgagggtga    120

 agcccgccgg cccgcgaact ggactggtgg atctctcaga cctggggccc cggactccga    180

 tctccgccgt ctccgccacc atcagggcgg gatccggctc tggtgttttg aggagggggt    240

 gtggtgtagg gaaaggaatc ccgtccctct ccaccttttt tcgccttcgg ggcttcagac    300

 tcagggaact cgctc atg gct ttc ttg atg aag aag aag aaa ttc aaa ttc     351
                  Met Ala Phe Leu Met Lys Lys Lys Lys Phe Lys Phe
                    1               5                  10

 caa act act ttc acc ctg gag gag ctg act gcg gtt ccc ttc gtg aac      399
 Gln Thr Thr Phe Thr Leu Glu Glu Leu Thr Ala Val Pro Phe Val Asn
          15                  20                  25

 ggg gtc ctc ttc tgc aag gtc cgg ctg ctg gat gga ggg gat ttt gtc      447
 Gly Val Leu Phe Cys Lys Val Arg Leu Leu Asp Gly Gly Asp Phe Val
      30                  35                  40

 agc ttg tcg tca agg gag gag gta cag gag aac tgt gtg cgg tgg cga      495
 Ser Leu Ser Ser Arg Glu Glu Val Gln Glu Asn Cys Val Arg Trp Arg
  45                  50                  55                  60

 aag agg ttc acc ttc gtg tgt aag atg agt gct aac ccg gcc acc ggc      543
 Lys Arg Phe Thr Phe Val Cys Lys Met Ser Ala Asn Pro Ala Thr Gly
                  65                  70                  75

 ctg ctg gac ccc tgt gtc ttc cgt gtg tct gtg cgc aag gag ctg aaa      591
 Leu Leu Asp Pro Cys Val Phe Arg Val Ser Val Arg Lys Glu Leu Lys
              80                  85                  90

 ggc ggg aag gct tat tcc aag ctg ggc ttc gct gac ttg aac ctg gcc      639
 Gly Gly Lys Ala Tyr Ser Lys Leu Gly Phe Ala Asp Leu Asn Leu Ala
          95                 100                 105

 gag ttt gcg ggc tcg ggc tcc acg gtg cgc tgc tgc ctg ctc gag gga      687
 Glu Phe Ala Gly Ser Gly Ser Thr Val Arg Cys Cys Leu Leu Glu Gly
     110                 115                 120

 tat gac acg aag aac act cgc cag gac aac tcc atc ctt aag gtc acc      735
 Tyr Asp Thr Lys Asn Thr Arg Gln Asp Asn Ser Ile Leu Lys Val Thr
 125                 130                 135                 140

 att ggt atg ttc ctg ctc tct gga gat ccc tgc ttc aag acg cca cca      783
 Ile Gly Met Phe Leu Leu Ser Gly Asp Pro Cys Phe Lys Thr Pro Pro
                 145                 150                 155

 tcg act gcc aag tcc atc tcc atc cca ggc cag gat tcc tcc ctg cag      831
 Ser Thr Ala Lys Ser Ile Ser Ile Pro Gly Gln Asp Ser Ser Leu Gln
             160                 165                 170

 ctg acg tgt aag ggt ggt ggg acc agc agt ggg ggc agc agc acc aac      879
 Leu Thr Cys Lys Gly Gly Gly Thr Ser Ser Gly Gly Ser Ser Thr Asn
         175                 180                 185

 tcc ctg act ggg tcc cgg ccc ccc aag gct cgg ccc act att ctc agc      927
 Ser Leu Thr Gly Ser Arg Pro Pro Lys Ala Arg Pro Thr Ile Leu Ser
     190                 195                 200

 tca ggg ctg cca gag gaa ccc gac cag aac ctg tcc agc cct gag gag      975
 Ser Gly Leu Pro Glu Glu Pro Asp Gln Asn Leu Ser Ser Pro Glu Glu
 205                 210                 215                 220

 gtg ttc cac tct ggc cac tcc cgc aac tcc agc tat gcc agc cag cag     1023
 Val Phe His Ser Gly His Ser Arg Asn Ser Ser Tyr Ala Ser Gln Gln
                 225                 230                 235

 tcc aag atc tcc ggc tac agc aca gag cac tca cgc tcc tcc agc ctc     1071
 Ser Lys Ile Ser Gly Tyr Ser Thr Glu His Ser Arg Ser Ser Ser Leu
             240                 245                 250

 tca gac ctg acg cac cgc cgc aac acg tcc acc agc agc agc gcc tct     1119
 Ser Asp Leu Thr His Arg Arg Asn Thr Ser Thr Ser Ser Ser Ala Ser
         255                 260                 265

 ggg ggc ctt ggc atg acc gtg gag ggc cct gag ggc agt gag cgg gag     1167
 Gly Gly Leu Gly Met Thr Val Glu Gly Pro Glu Gly Ser Glu Arg Glu
     270                 275                 280

 cac cgg ccc ccg gag aag ccg ccg cgg cca ccc cgg ccc ctg cat ctg     1215
 His Arg Pro Pro Glu Lys Pro Pro Arg Pro Pro Arg Pro Leu His Leu
 285                 290                 295                 300

 tcc gat cgc tct ttc agg cgg aag aag gac tcg gtg gag agc cac ccg     1263
 Ser Asp Arg Ser Phe Arg Arg Lys Lys Asp Ser Val Glu Ser His Pro
                 305                 310                 315

 gcc tgg gtg gac gac acg cgg atc gat gcg gat gcc atc gtg gag aag     1311
 Ala Trp Val Asp Asp Thr Arg Ile Asp Ala Asp Ala Ile Val Glu Lys
             320                 325                 330

 atc gtg cag agc cag gac ttc aca gat ggc agc aac acc gag gac agc     1359
 Ile Val Gln Ser Gln Asp Phe Thr Asp Gly Ser Asn Thr Glu Asp Ser
         335                 340                 345

 aac ctc cgg ctg ttc gtg agc cgc gat ggc tct gcc acg ctg agc ggc     1407
 Asn Leu Arg Leu Phe Val Ser Arg Asp Gly Ser Ala Thr Leu Ser Gly
     350                 355                 360

 atc cag ctt gcc acc agg gtc tct tct ggg gtc tac gag cca gtt gtg     1455
 Ile Gln Leu Ala Thr Arg Val Ser Ser Gly Val Tyr Glu Pro Val Val
 365                 370                 375                 380

 att gaa agc cat tga ggagcaggtg tccgggctgg agaagagtcc tgctttctct     1510
 Ile Glu Ser His 


 ggagtccaga cctgtatcat tccatgagga actttcccct tcagatcacc tctgcgccac   1570

 atctcatcca tgcctcctcc atgcactcca gtccacactc cccgtagcat cattccattg   1630

 cccctcccat ccatgctggg accctcctgg cccaccaagg cccaggcacc actgtgaata   1690

 ttctcctctg aaccactaga gggcaggcca ggcaggccag gcgggcccgt gcagcttgtg   1750

 ggcaagaagg agcctggcaa ggaccggcgc tgctggagac tgacccagcc ctctggctga   1810

 ggacatgcag cggctcctaa atgtagagat gcctgtggct gagggggcct ctctacctgt   1870

 gtccccactc actccaggag cactggcttt ggtcacgtct tagcagcagg gccttgctcc   1930

 gttgttctct tgtccccttg agctcagtga attcccacca ggtgcccaca gctcctggac   1990

 ttcaaattct atatattgag agagttggag agtatatcag agatattttt ggaaaggagt   2050

 tggtctatgc aatgtcagtt tggaatcttc ttgaaagttt aatgttttta ttaggagatt   2110

 taaagaaaat aaaggtctac aatatcttta aaaaaaaaaa a                       2151




      <210> 611
      <211> 1024
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (196)..(801)

      <400> 611
 cagcgagaga gcccgagggg agactttgac ttctagcctc agaactggag gaagtgtgcg     60

 cgccgccgcc gtcgtagctc ctgcagggct gaagacctag gcgataccat cttaccgagc    120

 accgggatcc cggcgtttga ggcgacgcgg gcgaacacca gagccagccg gctgcggctg    180

 cccacacggc tcacc atg ggc tcc ggg cgc cgg gcg ctg tcc gcg gtg ccg     231
                  Met Gly Ser Gly Arg Arg Ala Leu Ser Ala Val Pro
                    1               5                  10

 gcc gtg ctg ctg gtc ctc acg ctg ccg ggg ctg ccc gtc tgg gca cag      279
 Ala Val Leu Leu Val Leu Thr Leu Pro Gly Leu Pro Val Trp Ala Gln
          15                  20                  25

 aac gac acg gag ccc atc gtg ctg gag ggc aag tgt ctg gtg gtg tgc      327
 Asn Asp Thr Glu Pro Ile Val Leu Glu Gly Lys Cys Leu Val Val Cys
      30                  35                  40

 gac tcg aac ccg gcc acg gac tcc aag ggc tcc tct tcc tcc ccg ctg      375
 Asp Ser Asn Pro Ala Thr Asp Ser Lys Gly Ser Ser Ser Ser Pro Leu
  45                  50                  55                  60

 ggg ata tcg gtc cgg gcg gcc aac tcc aag gtc gcc ttc tcg gcg gtg      423
 Gly Ile Ser Val Arg Ala Ala Asn Ser Lys Val Ala Phe Ser Ala Val
                  65                  70                  75

 cgg agc acc aac cac gag cca tcc gag atg agc aac aag acg cgc atc      471
 Arg Ser Thr Asn His Glu Pro Ser Glu Met Ser Asn Lys Thr Arg Ile
              80                  85                  90

 att tac ttc gat cag atc ctg gtg aat gtg ggt aat ttt ttc aca ttg      519
 Ile Tyr Phe Asp Gln Ile Leu Val Asn Val Gly Asn Phe Phe Thr Leu
          95                 100                 105

 gag tct gtc ttt gta gca cca aga aaa gga att tac agt ttc agt ttt      567
 Glu Ser Val Phe Val Ala Pro Arg Lys Gly Ile Tyr Ser Phe Ser Phe
     110                 115                 120

 cac gtg att aaa gtc tac cag agc caa act atc cag gtt aac ttg atg      615
 His Val Ile Lys Val Tyr Gln Ser Gln Thr Ile Gln Val Asn Leu Met
 125                 130                 135                 140

 tta aat gga aaa cca gta ata tct gcc ttt gcg ggg gac aaa gat gtt      663
 Leu Asn Gly Lys Pro Val Ile Ser Ala Phe Ala Gly Asp Lys Asp Val
                 145                 150                 155

 act cgt gaa gct gcc acg aat ggt gtc ctg ctc tac cta gat aaa gag      711
 Thr Arg Glu Ala Ala Thr Asn Gly Val Leu Leu Tyr Leu Asp Lys Glu
             160                 165                 170

 gat aag gtt tac cta aaa ctg gag aaa ggt aat ttg gtt gga ggc tgg      759
 Asp Lys Val Tyr Leu Lys Leu Glu Lys Gly Asn Leu Val Gly Gly Trp
         175                 180                 185

 cag tat tcc acg ttt tct ggc ttt ctg gtg ttc ccc cta tag gattcaa      808
 Gln Tyr Ser Thr Phe Ser Gly Phe Leu Val Phe Pro Leu 
     190                 195                 200

 tttctccatg atgttcatcc aggtgaggga tgacccactc ctgagttatt ggaagatcat    868

 tttttcatca ttggattgat gtcttttatt ggtttctcat gggtggatat ggattctaag    928

 gattctagcc tgtctgaacc aatacaaaat ttcacagatt atttgtgtgt gtctgtttca    988

 gtatatttgg attgcgactc taagcagata atacct                             1024




      <210> 612
      <211> 1638
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (168)..(1322)

      <400> 612
 cgacgctaac gggctggcac tcgcggtccc acgtggctca ggacaccctt tcgggggcgt     60

 gtctcccagt tctagaggtt cccagagaag aggaggtgct cactaaccag gcagctcgcc    120

 cagactccgg gcagtgagag ggagggagcg ccggccgcgg gagcggg  atg gaa acc     176
                                                      Met Glu Thr
                                                        1

 agc agc ccg cgg ccc ccg cgg ccc agc tcc aac ccg ggg ctg agc ctg      224
 Ser Ser Pro Arg Pro Pro Arg Pro Ser Ser Asn Pro Gly Leu Ser Leu
       5                  10                  15

 gac gcc cgg ctg ggc gtg gac act cgc ctc tgg gcc aag gtg ctg ttc      272
 Asp Ala Arg Leu Gly Val Asp Thr Arg Leu Trp Ala Lys Val Leu Phe
  20                  25                  30                  35

 acc gcg ctc tac gca ctc atc tgg gcg ctg ggc gcg gcg ggc aat gcg      320
 Thr Ala Leu Tyr Ala Leu Ile Trp Ala Leu Gly Ala Ala Gly Asn Ala
                  40                  45                  50

 ctg tcc gtg cac gtg gtg ctg aag gcg cgg gcc ggg cgc gcg ggg cgc      368
 Leu Ser Val His Val Val Leu Lys Ala Arg Ala Gly Arg Ala Gly Arg
              55                  60                  65

 ctg cgc cac cac gtg ctc agc ctg gcg ctc gcg ggc ctg ctg ctg ctg      416
 Leu Arg His His Val Leu Ser Leu Ala Leu Ala Gly Leu Leu Leu Leu
          70                  75                  80

 ctg gtc ggc gtg ccg gtg gag ctc tac agc ttc gtg tgg ttc cac tac      464
 Leu Val Gly Val Pro Val Glu Leu Tyr Ser Phe Val Trp Phe His Tyr
      85                  90                  95

 ccc tgg gtc ttc ggc gac ctg ggc tgc cta gcc gtg tgc cag ccc ctg      512
 Pro Trp Val Phe Gly Asp Leu Gly Cys Leu Ala Val Cys Gln Pro Leu
 100                 105                 110                 115

 cgt gcc cgc agc ctg ctg acg cca cgc cgg acc cgg tgg ctg gtg gcg      560
 Arg Ala Arg Ser Leu Leu Thr Pro Arg Arg Thr Arg Trp Leu Val Ala
                 120                 125                 130

 ctc tcg tgg gcc gcc tcg ctc ggc ctc gcc ctg ccc atg gcc gtc atc      608
 Leu Ser Trp Ala Ala Ser Leu Gly Leu Ala Leu Pro Met Ala Val Ile
             135                 140                 145

 atg ggg cag aag cac gaa ctc gag acg gcg gac ggg gag ccg gag ccc      656
 Met Gly Gln Lys His Glu Leu Glu Thr Ala Asp Gly Glu Pro Glu Pro
         150                 155                 160

 gcc tcg cga gtg tgc acg gtg ctg gtg agc cgc acc gcg ctc caa gtc      704
 Ala Ser Arg Val Cys Thr Val Leu Val Ser Arg Thr Ala Leu Gln Val
     165                 170                 175

 ttt atc cag gtg aat gtg ctg gtg tcc ttc gtg ctc ccc ttg gca cta      752
 Phe Ile Gln Val Asn Val Leu Val Ser Phe Val Leu Pro Leu Ala Leu
 180                 185                 190                 195

 act gct ttc ctg aat ggg gtc aca gtg agc cac ctg ctg gcc ctc tgc      800
 Thr Ala Phe Leu Asn Gly Val Thr Val Ser His Leu Leu Ala Leu Cys
                 200                 205                 210

 tcc caa gtg ccg tcc act tct acc ccg ggc agc tcc acc ccc agc cgc      848
 Ser Gln Val Pro Ser Thr Ser Thr Pro Gly Ser Ser Thr Pro Ser Arg
             215                 220                 225

 ctg gag ctg ctg agt gag gag ggt ctc ctc agc ttc atc gta tgg aag      896
 Leu Glu Leu Leu Ser Glu Glu Gly Leu Leu Ser Phe Ile Val Trp Lys
         230                 235                 240

 aag acc ttt atc cag gga ggc cag gtc agc ctg gtg aga cat aaa gac      944
 Lys Thr Phe Ile Gln Gly Gly Gln Val Ser Leu Val Arg His Lys Asp
     245                 250                 255

 gtg cgc cgg atc cgc agc ctc cag cgc agc gtc cag gtt ctc aga gcc      992
 Val Arg Arg Ile Arg Ser Leu Gln Arg Ser Val Gln Val Leu Arg Ala
 260                 265                 270                 275

 atc gtg gtc atg tat gtc atc tgc tgg ctg ccg tac cat gcc cgc agg     1040
 Ile Val Val Met Tyr Val Ile Cys Trp Leu Pro Tyr His Ala Arg Arg
                 280                 285                 290

 ctc atg tac tgc tac gta cct gat gac gcg tgg act gac cca ctg tac     1088
 Leu Met Tyr Cys Tyr Val Pro Asp Asp Ala Trp Thr Asp Pro Leu Tyr
             295                 300                 305

 aat ttc tac cac tac ttc tac atg gtg acc aac aca ctt ttc tac gtc     1136
 Asn Phe Tyr His Tyr Phe Tyr Met Val Thr Asn Thr Leu Phe Tyr Val
         310                 315                 320

 agc tca gct gtg act cct ctt ctc tac aac gcc gtg tcc tcc tcc ttc     1184
 Ser Ser Ala Val Thr Pro Leu Leu Tyr Asn Ala Val Ser Ser Ser Phe
     325                 330                 335

 aga aaa ctc ttc ctg gaa gcc gtc agc tcc ctg tgt gga gag cac cac     1232
 Arg Lys Leu Phe Leu Glu Ala Val Ser Ser Leu Cys Gly Glu His His
 340                 345                 350                 355

 ccc atg aag cgg tta ccc ccg aag ccc cag agt ccc acc cta atg gat     1280
 Pro Met Lys Arg Leu Pro Pro Lys Pro Gln Ser Pro Thr Leu Met Asp
                 360                 365                 370

 aca gct tca ggc ttt ggg gat ccc cca gaa acc cgg acc tga atgtaat     1329
 Thr Ala Ser Gly Phe Gly Asp Pro Pro Glu Thr Arg Thr 
             375                 380

 gcaagaatga acagaacaag caaaatgacc agctgcttag tcacctggca aagcaggtga   1389

 gcaacctcat cactaatcat tcaagcttcg cagccagggc gacttctatc aacccctgct   1449

 ctgctgagaa ccatcaagcg cagggaagcc acgtgacccc tcctagcctc aggctccctc   1509

 gtctgtgtag tggagataaa gaacagcacc catctcttag tgttgcctga gactaaagtg   1569

 cttagcacag aacctggtgc gtagtagatg ctcaataaat ttttgctggc acgaaaaaaa   1629

 aaaaaaaaa                                                           1638




      <210> 613
      <211> 9942
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (295)..(9942)

      <400> 613
 cggacggggg cgggggcgcc tggggaggga ggggagagga tcccagccgc cgagtcgcag     60

 cctcgtggct gtctgctgag tcatggcaag cgctccccgc agccctggat cactcgcgta    120

 gcgcggctgg cgcggggtgc gcagccattg ggctgggcgc ggggccgcga gcgccaggca    180

 tgacgcgctg agccgcgctc acccgtgccc gccgtcccgg cgtgcgccca gcgcgggtgc    240

 ctgtgccgcc gccctccagc cccgccgtcg agtcgccctc gcctcgcccg cacc  atg     297
                                                              Met
                                                                1

 atc gcc gcg gct ttc ctc gtc ttg ctg aga ccc tac agc atc caa tgt      345
 Ile Ala Ala Ala Phe Leu Val Leu Leu Arg Pro Tyr Ser Ile Gln Cys
               5                  10                  15

 gcc ctc ttc ctc ttg ttg ctt ctg ctg ggc acc atc gcc acc atc gtc      393
 Ala Leu Phe Leu Leu Leu Leu Leu Leu Gly Thr Ile Ala Thr Ile Val
          20                  25                  30

 ttc ttc tgc tgc tgg cac cgc aag ctc cag aaa ggg agg cat ccg atg      441
 Phe Phe Cys Cys Trp His Arg Lys Leu Gln Lys Gly Arg His Pro Met
      35                  40                  45

 aaa tcg gtc ttc tcg ggt cgt tca aga agc cga gat gct gtt ttg aga      489
 Lys Ser Val Phe Ser Gly Arg Ser Arg Ser Arg Asp Ala Val Leu Arg
  50                  55                  60                  65

 tcg cac cac ttt cgt tct gag gga ttc aga gca agc cct cgg cat ctt      537
 Ser His His Phe Arg Ser Glu Gly Phe Arg Ala Ser Pro Arg His Leu
                  70                  75                  80

 aga aga cga gtt gca gcg gcc gca gct gcc cgt ctg gaa gaa gtg aag      585
 Arg Arg Arg Val Ala Ala Ala Ala Ala Ala Arg Leu Glu Glu Val Lys
              85                  90                  95

 ccc gtg gtg gaa gtt cac cat cag agt gag caa gaa act tca gtg agg      633
 Pro Val Val Glu Val His His Gln Ser Glu Gln Glu Thr Ser Val Arg
         100                 105                 110

 aaa cga aga atc aag aag agc agc cga gtc cag cca gaa ttt tat cac      681
 Lys Arg Arg Ile Lys Lys Ser Ser Arg Val Gln Pro Glu Phe Tyr His
     115                 120                 125

 tct gtt caa ggt gct tca atc agg agg cct agt tcc ggg aac gcg tcc      729
 Ser Val Gln Gly Ala Ser Ile Arg Arg Pro Ser Ser Gly Asn Ala Ser
 130                 135                 140                 145

 tat cgc tgc tct atg tct tcc tct gcg gat ttt tcc gat gag gaa gat      777
 Tyr Arg Cys Ser Met Ser Ser Ser Ala Asp Phe Ser Asp Glu Glu Asp
                 150                 155                 160

 ttc agc cag aaa tct ggc tcc gca tcc cca gct ccg gga gac acc tta      825
 Phe Ser Gln Lys Ser Gly Ser Ala Ser Pro Ala Pro Gly Asp Thr Leu
             165                 170                 175

 ccc tgg aat ttg cct aaa cat gag aga tcg aaa aga aag att caa ggg      873
 Pro Trp Asn Leu Pro Lys His Glu Arg Ser Lys Arg Lys Ile Gln Gly
         180                 185                 190

 ggc tca gtg ctg gac cct gcc gag agg gca gtg ctt cgg ata gca gat      921
 Gly Ser Val Leu Asp Pro Ala Glu Arg Ala Val Leu Arg Ile Ala Asp
     195                 200                 205

 gaa cgg gac aaa gtt cag aag aaa aca ttt aca aaa tgg ata aat cag      969
 Glu Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Gln
 210                 215                 220                 225

 cat ctc atg aag gtt cga aaa cat gtg aat gat ctc tat gaa gac tta     1017
 His Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp Leu
                 230                 235                 240

 agg gat gga cac aat ttg att tct ctt tta gag gtt ctt tca gga gat     1065
 Arg Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp
             245                 250                 255

 acc ttg ccc aga gaa aaa ggt cgg atg cgt ttt cac aga cta cag aat     1113
 Thr Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln Asn
         260                 265                 270

 gta caa att gca ctt gac tat ttg aaa aga cgc cag gtg aaa tta gtg     1161
 Val Gln Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu Val
     275                 280                 285

 aat att aga aat gat gac ata aca gat gga aat ccc aaa ttg act ttg     1209
 Asn Ile Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu
 290                 295                 300                 305

 gga tta atc tgg aca ata att ttg cac ttt cag ata tct gat atc cat     1257
 Gly Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile His
                 310                 315                 320

 gtt act gga gag tca gag gat atg tct gca aaa gag aga ttg cta ctc     1305
 Val Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu Leu
             325                 330                 335

 tgg acg cag cag gca aca gag ggt tat gct gga att cgg tgt gaa aat     1353
 Trp Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu Asn
         340                 345                 350

 ttc act acc tgc tgg aga gat gga aaa tta ttt aat gcc atc att cat     1401
 Phe Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile His
     355                 360                 365

 aaa tac agg ccg gac ctg ata gat atg aat act gtt gct gtt caa agc     1449
 Lys Tyr Arg Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln Ser
 370                 375                 380                 385

 aac ctt gca aat tta gag cat gct ttt tac gta gca gaa aaa att ggt     1497
 Asn Leu Ala Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile Gly
                 390                 395                 400

 gtt ata aga ctt ctg gac cct gaa gat gtc gat gtc tcc tca cct gat     1545
 Val Ile Arg Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro Asp
             405                 410                 415

 gaa aaa tca gta ata act tac gtg tca tct ctc tat gat gca ttt cct     1593
 Glu Lys Ser Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe Pro
         420                 425                 430

 aaa gtc cct gaa ggt ggg gaa ggc att ggt gca aat gat gtt gaa gtc     1641
 Lys Val Pro Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu Val
     435                 440                 445

 aaa tgg att gaa tac cag aat atg gtg aac tac ctc atc caa tgg att     1689
 Lys Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp Ile
 450                 455                 460                 465

 aga cac cat gtg acc aca atg tct gag aga aca ttt cct aat aat cct     1737
 Arg His His Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn Pro
                 470                 475                 480

 gta gaa ctg aag gca ctt tat aat cag tat tta cag ttt aaa gaa aca     1785
 Val Glu Leu Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu Thr
             485                 490                 495

 gaa att cca cca aag gag aca gaa aaa tca aaa att aaa cga cta tat     1833
 Glu Ile Pro Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu Tyr
         500                 505                 510

 aaa tta tta gag aaa gtt ttt tgt ttt ctc aag att tgg ata gaa ttt     1881
 Lys Leu Leu Glu Lys Val Phe Cys Phe Leu Lys Ile Trp Ile Glu Phe
     515                 520                 525

 gga cgc atc aag ctc ctt caa ggt tat cat cca aat gac ata gaa aaa     1929
 Gly Arg Ile Lys Leu Leu Gln Gly Tyr His Pro Asn Asp Ile Glu Lys
 530                 535                 540                 545

 gag tgg ggg aaa ctc att att gcc atg cta gag aga gag aag gcc ctt     1977
 Glu Trp Gly Lys Leu Ile Ile Ala Met Leu Glu Arg Glu Lys Ala Leu
                 550                 555                 560

 cgt cca gaa gta gaa agg tta gaa atg ttg caa cag att gcc aac aga     2025
 Arg Pro Glu Val Glu Arg Leu Glu Met Leu Gln Gln Ile Ala Asn Arg
             565                 570                 575

 gtt cag agg gac agt gtc atc tgt gaa gac aaa ctg att ctt gct gga     2073
 Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly
         580                 585                 590

 aat gct ctt cag tct gat tct aaa aga tta gaa tca gga gtg cag ttt     2121
 Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val Gln Phe
     595                 600                 605

 cag aat gaa gca gaa att gct ggg tat ata ctt gaa tgt gag aac ctt     2169
 Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu
 610                 615                 620                 625

 tta cgc cag cat gta att gat gta cag att ctt att gat gga aaa tac     2217
 Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr
                 630                 635                 640

 tac cag gca gat caa ttg gta cag agg gtt gca aaa ctg cgt gac gaa     2265
 Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg Asp Glu
             645                 650                 655

 att atg gcc tta agg aac gaa tgt tct tct gtg tac agc aaa gga cgc     2313
 Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg
         660                 665                 670

 ata ctg aca aca gaa cag aca aag ctc atg ata tca gga atc act caa     2361
 Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile Thr Gln
     675                 680                 685

 agt tta aac tca gga ttt gca cag acc tta cac cct agt ctg acc tca     2409
 Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu Thr Ser
 690                 695                 700                 705

 ggg ctg acc cag agt tta aca cct tcc cta acc tct tct agt atg act     2457
 Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser Met Thr
                 710                 715                 720

 tct ggc ctg tca tca ggg atg act tcc cgc ctg act cca tct gtc act     2505
 Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser Val Thr
             725                 730                 735

 cca gct tat aca cct ggt ttc cca tca gga tta gtt cca aat ttc agt     2553
 Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn Phe Ser
         740                 745                 750

 tca gga gta gag cca aat tca ttg caa act ttg aag ttg atg cag atc     2601
 Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met Gln Ile
     755                 760                 765

 cga aaa ccc ctt cta aag tct tct ttg ctg gat caa aat tta aca gaa     2649
 Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu Thr Glu
 770                 775                 780                 785

 gaa gaa atc aat atg aaa ttt gtt cag gat ctt ttg aat tgg gtt gat     2697
 Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp Val Asp
                 790                 795                 800

 gag atg cag gta caa ctg gac cgc act gag tgg ggc tca gat ttg cca     2745
 Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp Leu Pro
             805                 810                 815

 agt gtt gaa agc cat tta gaa aat cat aaa aat gtt cat aga gct att     2793
 Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg Ala Ile
         820                 825                 830

 gaa gaa ttt gaa tct agt ctc aaa gaa gct aaa atc agt gag att caa     2841
 Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu Ile Gln
     835                 840                 845

 atg aca gca cct ctt aaa ctg act tat gca gaa aag ttg cac aga tta     2889
 Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His Arg Leu
 850                 855                 860                 865

 gag agt cag tat gca aaa ctc ttg ttt tcc tta cta aag aat aca tcc     2937
 Glu Ser Gln Tyr Ala Lys Leu Leu Phe Ser Leu Leu Lys Asn Thr Ser
                 870                 875                 880

 agg aat caa gaa cgg cac ctt gat aca ctc cat aat ttt gta agt cgt     2985
 Arg Asn Gln Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg
             885                 890                 895

 gcg act aat gaa ctt att tgg ttg aat gaa aaa gaa gag gag gaa gtt     3033
 Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val
         900                 905                 910

 gct tat gac tgg agt gag aga aac acc aac ata gct agg aaa aaa gat     3081
 Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp
     915                 920                 925

 tat cat gct gaa tta atg aga gaa ctt gat caa aag gaa gaa aat att     3129
 Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile
 930                 935                 940                 945

 aaa tca gtt cag gag ata gca gag cag cta ctt cta gaa aat cat cca     3177
 Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro
                 950                 955                 960

 gcc cgg tta act att gag gta aag ctg gaa agt gta atg gtg ttg gtt     3225
 Ala Arg Leu Thr Ile Glu Val Lys Leu Glu Ser Val Met Val Leu Val
             965                 970                 975

 gaa tat gcc tac aga gcg gca atg cag acg cag tgg agc tgg atc tta     3273
 Glu Tyr Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile Leu
         980                 985                 990

 cag ctc tgc cag tgt gtg gag cag cac ata aag gag aac aca gcg tat     3321
 Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala Tyr
     995                1000                1005

 ttc gag ttt ttc aat gat gcc aaa gaa gct act gat tac tta agg aat     3369
 Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg Asn
1010                1015                1020                1025

 cta aaa gat gcc att cag cgg aag tac agc tgt gat aga tca agc agc     3417
 Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser Ser
                1030                1035                1040

 att cac aag cta gaa gac ctt gtt cag gaa tca atg gaa gag aaa gaa     3465
 Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys Glu
            1045                1050                1055

 gaa ctt ctg cag tac aaa agc act ata gca aac cta atg gga aaa gca     3513
 Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys Ala
        1060                1065                1070

 aaa aca ata att caa ctg aag cca agg aat tct gac tgt cca ctc aaa     3561
 Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu Lys
    1075                1080                1085

 act tct att ccg atc aaa gct atc tgt gac tac aga caa att gag ata     3609
 Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu Ile
1090                1095                1100                1105

 acc att tac aaa gac gat gaa tgt gtt ttg gcg aat aac tct cat cgt     3657
 Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His Arg
                1110                1115                1120

 gct aaa tgg aag gtc att agt cct act ggg aat gag gct atg gtc cca     3705
 Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val Pro
            1125                1130                1135

 tct gtg tgc ttc acc gtt cct cca cca aac aaa gaa gcg gtg gac ctt     3753
 Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp Leu
        1140                1145                1150

 gcc aac aga att gag caa cag tat cag aat gtc ctg act ctt tgg cat     3801
 Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp His
    1155                1160                1165

 gag tct cac ata aac atg aag agt gta gta tcc tgg cat tat ctc atc     3849
 Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu Ile
1170                1175                1180                1185

 aat gaa att gat aga att cga gct agc aat gtg gct tca gta agt atg     3897
 Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Val Ser Met
                1190                1195                1200

 aat ctg ata aag aca atg cta cct ggt gaa cat cag caa gtt cta agt     3945
 Asn Leu Ile Lys Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser
            1205                1210                1215

 aat cta caa tct cgt ttt gaa gat ttt ctg gaa gat agc cag gaa tcc     3993
 Asn Leu Gln Ser Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser
        1220                1225                1230

 caa gtc ttt tca ggc tca gat ata aca caa ctg gaa aag gag gtt aat     4041
 Gln Val Phe Ser Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn
    1235                1240                1245

 gta tgt aag cag tat tat caa gaa ctt ctt aaa tct gca gaa aga gag     4089
 Val Cys Lys Gln Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu
1250                1255                1260                1265

 gag caa gag gaa tca gtt tat aat ctc tac atc tct gaa gtt cga aac     4137
 Glu Gln Glu Glu Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn
                1270                1275                1280

 att aga ctt cgg tta gag aac tgt gaa gat cgg ctg att aga cag att     4185
 Ile Arg Leu Arg Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile
            1285                1290                1295

 cga act ccc ctg gaa aga gat gat ttg cat gaa agt gtg ttc aga atc     4233
 Arg Thr Pro Leu Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile
        1300                1305                1310

 aca gaa cag gag aaa cta aag aaa gag ctg gaa cga ctt aaa gat gat     4281
 Thr Glu Gln Glu Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp
    1315                1320                1325

 ttg gga aca atc aca aat aag tgt gag gag ttt ttc agt caa gca gca     4329
 Leu Gly Thr Ile Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala
1330                1335                1340                1345

 gcc tct tca tca gtc cct acc cta cga tca gag ctt aat gtg gtc ctt     4377
 Ala Ser Ser Ser Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu
                1350                1355                1360

 cag aac atg aac caa gtc tat tct atg tct tcc act tac ata gat aag     4425
 Gln Asn Met Asn Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys
            1365                1370                1375

 tat gta act gct atc tca ata tat aaa ggc tat tgt tta att tcc ttt     4473
 Tyr Val Thr Ala Ile Ser Ile Tyr Lys Gly Tyr Cys Leu Ile Ser Phe
        1380                1385                1390

 tta agg ttg aaa act gtt aac ttg gtg tta aaa aac act caa gct gca     4521
 Leu Arg Leu Lys Thr Val Asn Leu Val Leu Lys Asn Thr Gln Ala Ala
    1395                1400                1405

 gaa gcc ctc gta aaa ctc tat gaa act aaa ctg tgt gaa gaa gaa gca     4569
 Glu Ala Leu Val Lys Leu Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala
1410                1415                1420                1425

 gtt ata gct gac aag aat aat att gag aat cta ata agt act tta aag     4617
 Val Ile Ala Asp Lys Asn Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys
                1430                1435                1440

 caa tgg aga tct gaa gta gat gaa aag aga cag gta ttc cat gcc tta     4665
 Gln Trp Arg Ser Glu Val Asp Glu Lys Arg Gln Val Phe His Ala Leu
            1445                1450                1455

 gag gat gag ttg cag aaa gct aaa gcc atc agt gat gaa atg ttt aaa     4713
 Glu Asp Glu Leu Gln Lys Ala Lys Ala Ile Ser Asp Glu Met Phe Lys
        1460                1465                1470

 acg tat aaa gaa cgg gac ctt gat ttt gac tgg cac aaa gaa aaa gca     4761
 Thr Tyr Lys Glu Arg Asp Leu Asp Phe Asp Trp His Lys Glu Lys Ala
    1475                1480                1485

 gat caa tta gtt gaa agg tgg caa aat gtt cat gtg cag att gac aac     4809
 Asp Gln Leu Val Glu Arg Trp Gln Asn Val His Val Gln Ile Asp Asn
1490                1495                1500                1505

 agg tta cgg gac tta gag ggc att ggc aaa tca ctg aag tac tac aga     4857
 Arg Leu Arg Asp Leu Glu Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg
                1510                1515                1520

 gac act tac cat cct tta gat gat tgg atc cag cag gtt gaa act act     4905
 Asp Thr Tyr His Pro Leu Asp Asp Trp Ile Gln Gln Val Glu Thr Thr
            1525                1530                1535

 cag aga aag att cag gaa aat cag cct gaa aat agt aaa acc cta gcc     4953
 Gln Arg Lys Ile Gln Glu Asn Gln Pro Glu Asn Ser Lys Thr Leu Ala
        1540                1545                1550

 aca cag ttg aat caa cag aag atg ctg gtg tcc gaa ata gaa atg aaa     5001
 Thr Gln Leu Asn Gln Gln Lys Met Leu Val Ser Glu Ile Glu Met Lys
    1555                1560                1565

 cag agc aaa atg gac gag tgt caa aaa tat gca gaa cag tac tca gct     5049
 Gln Ser Lys Met Asp Glu Cys Gln Lys Tyr Ala Glu Gln Tyr Ser Ala
1570                1575                1580                1585

 aca gtg aag gac tat gaa tta caa aca atg acc tac cgg gcc atg gta     5097
 Thr Val Lys Asp Tyr Glu Leu Gln Thr Met Thr Tyr Arg Ala Met Val
                1590                1595                1600

 gat tca caa caa aaa tct cca gtg aaa cgc cga aga atg cag agt tca     5145
 Asp Ser Gln Gln Lys Ser Pro Val Lys Arg Arg Arg Met Gln Ser Ser
            1605                1610                1615

 gca gat ctc att att caa gag ttc atg gac cta agg act cga tat act     5193
 Ala Asp Leu Ile Ile Gln Glu Phe Met Asp Leu Arg Thr Arg Tyr Thr
        1620                1625                1630

 gcc ctg gtc act ctc atg aca caa tat att aaa ttt gct ggt gat tca     5241
 Ala Leu Val Thr Leu Met Thr Gln Tyr Ile Lys Phe Ala Gly Asp Ser
    1635                1640                1645

 ttg aag agg ctg gaa gag gag gag gta atc att aac agt gag cac cct     5289
 Leu Lys Arg Leu Glu Glu Glu Glu Val Ile Ile Asn Ser Glu His Pro
1650                1655                1660                1665

 gta aat ata aag gag cta gag att aaa agg tgt aag gag act tct gaa     5337
 Val Asn Ile Lys Glu Leu Glu Ile Lys Arg Cys Lys Glu Thr Ser Glu
                1670                1675                1680

 cat ggg gca tat tca gat ctg ctt cag cgt cag aag gca aca gtg ctt     5385
 His Gly Ala Tyr Ser Asp Leu Leu Gln Arg Gln Lys Ala Thr Val Leu
            1685                1690                1695

 gag aat agc aaa ctt aca gga aag ata agt gag ttg gaa aga atg gta     5433
 Glu Asn Ser Lys Leu Thr Gly Lys Ile Ser Glu Leu Glu Arg Met Val
        1700                1705                1710

 gct gaa cta aag aaa caa aag tcc cga gta gag gaa gaa ctt ccg aag     5481
 Ala Glu Leu Lys Lys Gln Lys Ser Arg Val Glu Glu Glu Leu Pro Lys
    1715                1720                1725

 gtc agg gag gct gca gaa aat gaa ttg aga aag cag cag aga aat gta     5529
 Val Arg Glu Ala Ala Glu Asn Glu Leu Arg Lys Gln Gln Arg Asn Val
1730                1735                1740                1745

 gaa gat atc tct ctg cag aag ata agg gct gaa agt gaa gcc aag cag     5577
 Glu Asp Ile Ser Leu Gln Lys Ile Arg Ala Glu Ser Glu Ala Lys Gln
                1750                1755                1760

 tac cgc agg gaa ctt gaa acc att gtg aga gag aag gaa gcc gct gaa     5625
 Tyr Arg Arg Glu Leu Glu Thr Ile Val Arg Glu Lys Glu Ala Ala Glu
            1765                1770                1775

 aga gaa ctg gag cgg gtg agg cag ctc acc ata gag gcc gag gct aaa     5673
 Arg Glu Leu Glu Arg Val Arg Gln Leu Thr Ile Glu Ala Glu Ala Lys
        1780                1785                1790

 aga gct gcc gtg gaa gag aac ctc ctg aat ttt cgc aat cag ttg gag     5721
 Arg Ala Ala Val Glu Glu Asn Leu Leu Asn Phe Arg Asn Gln Leu Glu
    1795                1800                1805

 gaa aac acc ttt acc aga cga aca ctg gaa gat cat ctt aaa aga aaa     5769
 Glu Asn Thr Phe Thr Arg Arg Thr Leu Glu Asp His Leu Lys Arg Lys
1810                1815                1820                1825

 gat tta agt ctc aat gat ttg gag caa caa aaa aat aaa tta atg gaa     5817
 Asp Leu Ser Leu Asn Asp Leu Glu Gln Gln Lys Asn Lys Leu Met Glu
                1830                1835                1840

 gaa tta aga aga aag aga gac aat gag gaa gaa ctc ttg aag ctg ata     5865
 Glu Leu Arg Arg Lys Arg Asp Asn Glu Glu Glu Leu Leu Lys Leu Ile
            1845                1850                1855

 aag cag atg gaa aaa gac ctt gca ttt cag aaa cag gta gca gag aaa     5913
 Lys Gln Met Glu Lys Asp Leu Ala Phe Gln Lys Gln Val Ala Glu Lys
        1860                1865                1870

 cag ttg aaa gaa aag cag aaa att gaa ttg gaa gca aga aga aaa ata     5961
 Gln Leu Lys Glu Lys Gln Lys Ile Glu Leu Glu Ala Arg Arg Lys Ile
    1875                1880                1885

 act gaa att cag tat aca tgt aga gaa aat gca ttg cca gtg tgt ccg     6009
 Thr Glu Ile Gln Tyr Thr Cys Arg Glu Asn Ala Leu Pro Val Cys Pro
1890                1895                1900                1905

 atc aca cag gct aca tca tgc agg gca gta acg ggt ctc cag caa gaa     6057
 Ile Thr Gln Ala Thr Ser Cys Arg Ala Val Thr Gly Leu Gln Gln Glu
                1910                1915                1920

 cat gac aag cag aaa gca gaa gaa ctc aaa cag cag gta gat gaa cta     6105
 His Asp Lys Gln Lys Ala Glu Glu Leu Lys Gln Gln Val Asp Glu Leu
            1925                1930                1935

 aca gct gcc aat aga aag gct gaa caa gac atg aga gag ctg aca tat     6153
 Thr Ala Ala Asn Arg Lys Ala Glu Gln Asp Met Arg Glu Leu Thr Tyr
        1940                1945                1950

 gaa ctt aat gcc ctc cag ctt gaa aaa acg tca tct gag gaa aag gct     6201
 Glu Leu Asn Ala Leu Gln Leu Glu Lys Thr Ser Ser Glu Glu Lys Ala
    1955                1960                1965

 cgt ttg cta aaa gat aaa cta gat gaa aca aat aat aca ctc aga tgc     6249
 Arg Leu Leu Lys Asp Lys Leu Asp Glu Thr Asn Asn Thr Leu Arg Cys
1970                1975                1980                1985

 ctt aag ttg gag ctg gaa agg aag gat cag gcg gag aaa ggg tat tct     6297
 Leu Lys Leu Glu Leu Glu Arg Lys Asp Gln Ala Glu Lys Gly Tyr Ser
                1990                1995                2000

 caa caa ctc aga gag ctt ggt agg caa ttg aat caa acc aca ggt aaa     6345
 Gln Gln Leu Arg Glu Leu Gly Arg Gln Leu Asn Gln Thr Thr Gly Lys
            2005                2010                2015

 gct gaa gaa gcc atg caa gaa gct agt gat ctc aag aaa ata aag cgc     6393
 Ala Glu Glu Ala Met Gln Glu Ala Ser Asp Leu Lys Lys Ile Lys Arg
        2020                2025                2030

 aat tat cag tta gaa tta gaa tct ctt aat cat gaa aaa ggg aaa cta     6441
 Asn Tyr Gln Leu Glu Leu Glu Ser Leu Asn His Glu Lys Gly Lys Leu
    2035                2040                2045

 caa aga gaa gta gac aga atc aca agg gca cat gct gta gct gag aag     6489
 Gln Arg Glu Val Asp Arg Ile Thr Arg Ala His Ala Val Ala Glu Lys
2050                2055                2060                2065

 aat att cag cat tta aat tca caa att cat tct ttt cga gat gag aaa     6537
 Asn Ile Gln His Leu Asn Ser Gln Ile His Ser Phe Arg Asp Glu Lys
                2070                2075                2080

 gaa tta gaa aga cta caa atc tgc cag aga aaa tca gat cat cta aaa     6585
 Glu Leu Glu Arg Leu Gln Ile Cys Gln Arg Lys Ser Asp His Leu Lys
            2085                2090                2095

 gaa caa ttt gag aaa agc cat gag cag ttg ctt caa aat atc aaa gct     6633
 Glu Gln Phe Glu Lys Ser His Glu Gln Leu Leu Gln Asn Ile Lys Ala
        2100                2105                2110

 gaa aaa gaa aat aat gat aaa atc caa agg ctc aat gaa gaa ttg gag     6681
 Glu Lys Glu Asn Asn Asp Lys Ile Gln Arg Leu Asn Glu Glu Leu Glu
    2115                2120                2125

 aaa agt aat gag tgt gca gag atg cta aaa caa aaa gta gag gag ctt     6729
 Lys Ser Asn Glu Cys Ala Glu Met Leu Lys Gln Lys Val Glu Glu Leu
2130                2135                2140                2145

 act agg cag aat aat gaa acc aaa tta atg atg cag aga att cag gca     6777
 Thr Arg Gln Asn Asn Glu Thr Lys Leu Met Met Gln Arg Ile Gln Ala
                2150                2155                2160

 gaa tca gag aat ata gtt tta gag aaa caa act atc cag caa aga tgt     6825
 Glu Ser Glu Asn Ile Val Leu Glu Lys Gln Thr Ile Gln Gln Arg Cys
            2165                2170                2175

 gaa gca ctg aaa att cag gca gat ggt ttt aaa gat cag cta cgc agc     6873
 Glu Ala Leu Lys Ile Gln Ala Asp Gly Phe Lys Asp Gln Leu Arg Ser
        2180                2185                2190

 aca aat gaa cac ttg cat aaa cag aca aaa aca gag cag gat ttt caa     6921
 Thr Asn Glu His Leu His Lys Gln Thr Lys Thr Glu Gln Asp Phe Gln
    2195                2200                2205

 aga aaa att aaa tgc cta gaa gaa gac ctg gcg aaa agt caa aat ttg     6969
 Arg Lys Ile Lys Cys Leu Glu Glu Asp Leu Ala Lys Ser Gln Asn Leu
2210                2215                2220                2225

 gta agt gaa ttt aag caa aag tgt gac caa cag aac att atc atc cag     7017
 Val Ser Glu Phe Lys Gln Lys Cys Asp Gln Gln Asn Ile Ile Ile Gln
                2230                2235                2240

 aat acc aag aaa gaa gtt aga aat ctg aat gcg gaa ctg aat gct tcc     7065
 Asn Thr Lys Lys Glu Val Arg Asn Leu Asn Ala Glu Leu Asn Ala Ser
            2245                2250                2255

 aaa gaa gag aag cga cgc ggg gag cag aaa gtt cag cta caa caa gct     7113
 Lys Glu Glu Lys Arg Arg Gly Glu Gln Lys Val Gln Leu Gln Gln Ala
        2260                2265                2270

 cag gtg caa gag tta aat aac agg ttg aaa aaa gta caa gac gaa tta     7161
 Gln Val Gln Glu Leu Asn Asn Arg Leu Lys Lys Val Gln Asp Glu Leu
    2275                2280                2285

 cac tta aag acc ata gag gag cag atg acc cac aga aag atg gtt ctg     7209
 His Leu Lys Thr Ile Glu Glu Gln Met Thr His Arg Lys Met Val Leu
2290                2295                2300                2305

 ttt cag gaa gaa tct ggt aaa ttc aaa caa tca gca gag gag ttt cgg     7257
 Phe Gln Glu Glu Ser Gly Lys Phe Lys Gln Ser Ala Glu Glu Phe Arg
                2310                2315                2320

 aag aag atg gaa aaa tta atg gag tcc aaa gtc atc act gaa aat gat     7305
 Lys Lys Met Glu Lys Leu Met Glu Ser Lys Val Ile Thr Glu Asn Asp
            2325                2330                2335

 att tca ggc att agg ctt gac ttt gtg tct ctt caa caa gaa aac tct     7353
 Ile Ser Gly Ile Arg Leu Asp Phe Val Ser Leu Gln Gln Glu Asn Ser
        2340                2345                2350

 aga gcc caa gaa aat gct aag ctt tgt gaa aca aac att aaa gaa ctt     7401
 Arg Ala Gln Glu Asn Ala Lys Leu Cys Glu Thr Asn Ile Lys Glu Leu
    2355                2360                2365

 gaa aga cag ctt caa cag tat cgt gaa caa atg cag caa ggg cag cac     7449
 Glu Arg Gln Leu Gln Gln Tyr Arg Glu Gln Met Gln Gln Gly Gln His
2370                2375                2380                2385

 atg gaa gca aat cat tac caa aaa tgt cag aaa ctt gag gat gag ctg     7497
 Met Glu Ala Asn His Tyr Gln Lys Cys Gln Lys Leu Glu Asp Glu Leu
                2390                2395                2400

 ata gcc cag aag cgt gag gtt gaa aac ctg aag caa aaa atg gac caa     7545
 Ile Ala Gln Lys Arg Glu Val Glu Asn Leu Lys Gln Lys Met Asp Gln
            2405                2410                2415

 cag atc aaa gag cat gaa cat caa tta gtt ttg ctc cag tgt gaa att     7593
 Gln Ile Lys Glu His Glu His Gln Leu Val Leu Leu Gln Cys Glu Ile
        2420                2425                2430

 caa aaa aag agc aca gcc aaa gac tgt acc ttc aaa cca gat ttt gag     7641
 Gln Lys Lys Ser Thr Ala Lys Asp Cys Thr Phe Lys Pro Asp Phe Glu
    2435                2440                2445

 atg aca gtg aag gag tgc cag cac tct gga gag ctg tcc tct aga aac     7689
 Met Thr Val Lys Glu Cys Gln His Ser Gly Glu Leu Ser Ser Arg Asn
2450                2455                2460                2465

 act gga cac ctt cac cca aca ccc aga tcc cct ctg ttg aga tgg act     7737
 Thr Gly His Leu His Pro Thr Pro Arg Ser Pro Leu Leu Arg Trp Thr
                2470                2475                2480

 caa gaa cca cag cca ttg gaa gag aag tgg cag cat cgg gtt gtt gaa     7785
 Gln Glu Pro Gln Pro Leu Glu Glu Lys Trp Gln His Arg Val Val Glu
            2485                2490                2495

 cag ata ccc aaa gaa gtc caa ttc cag cca cca ggg gct cca ctc gag     7833
 Gln Ile Pro Lys Glu Val Gln Phe Gln Pro Pro Gly Ala Pro Leu Glu
        2500                2505                2510

 aaa gag aaa agc cag cag tgt tac tct gag tac ttt tct cag aca agc     7881
 Lys Glu Lys Ser Gln Gln Cys Tyr Ser Glu Tyr Phe Ser Gln Thr Ser
    2515                2520                2525

 acc gag tta cag ata act ttt gat gag aca aac ccc att aca aga ctg     7929
 Thr Glu Leu Gln Ile Thr Phe Asp Glu Thr Asn Pro Ile Thr Arg Leu
2530                2535                2540                2545

 tct gaa att gag aag ata aga gac caa gcc ctg aac aat tct aga cca     7977
 Ser Glu Ile Glu Lys Ile Arg Asp Gln Ala Leu Asn Asn Ser Arg Pro
                2550                2555                2560

 cct gtt agg tat caa gat aac gca tgt gaa atg gaa ctg gtg aag gtt     8025
 Pro Val Arg Tyr Gln Asp Asn Ala Cys Glu Met Glu Leu Val Lys Val
            2565                2570                2575

 ttg aca ccc tta gag ata gct aag aac aag cag tat gat atg cat aca     8073
 Leu Thr Pro Leu Glu Ile Ala Lys Asn Lys Gln Tyr Asp Met His Thr
        2580                2585                2590

 gaa gtc aca aca tta aaa caa gaa aag aac cca gtt ccc agt gct gaa     8121
 Glu Val Thr Thr Leu Lys Gln Glu Lys Asn Pro Val Pro Ser Ala Glu
    2595                2600                2605

 gaa tgg atg ctt gaa ggg tgc aga gca tct ggt gga ctc aag aaa ggg     8169
 Glu Trp Met Leu Glu Gly Cys Arg Ala Ser Gly Gly Leu Lys Lys Gly
2610                2615                2620                2625

 gat ttc ctt aag aag ggc tta gaa cca gag acc ttc cag aac ttt gat     8217
 Asp Phe Leu Lys Lys Gly Leu Glu Pro Glu Thr Phe Gln Asn Phe Asp
                2630                2635                2640

 ggt gat cat gca tgt tca gtc agg gat gat gaa ttt aaa ttc caa ggg     8265
 Gly Asp His Ala Cys Ser Val Arg Asp Asp Glu Phe Lys Phe Gln Gly
            2645                2650                2655

 ctt agg cac act gtg act gcc agg cag ttg gtg gaa gct aag ctt ctg     8313
 Leu Arg His Thr Val Thr Ala Arg Gln Leu Val Glu Ala Lys Leu Leu
        2660                2665                2670

 gac atg aga aca att gag cag ctg cga ctc ggt ctt aag act gtt gaa     8361
 Asp Met Arg Thr Ile Glu Gln Leu Arg Leu Gly Leu Lys Thr Val Glu
    2675                2680                2685

 gaa gtt cag aaa act ctt aac aag ttt ctg acg aaa gcc acc tca att     8409
 Glu Val Gln Lys Thr Leu Asn Lys Phe Leu Thr Lys Ala Thr Ser Ile
2690                2695                2700                2705

 gca ggg ctt tac cta gaa tct aca aaa gaa aag att tca ttt gcc tca     8457
 Ala Gly Leu Tyr Leu Glu Ser Thr Lys Glu Lys Ile Ser Phe Ala Ser
                2710                2715                2720

 gcg gcc gag aga atc ata ata gac aaa atg gtg gct ttg gca ttt tta     8505
 Ala Ala Glu Arg Ile Ile Ile Asp Lys Met Val Ala Leu Ala Phe Leu
            2725                2730                2735

 gaa gct cag gct gca aca ggt ttt ata att gat ccc att tca ggt cag     8553
 Glu Ala Gln Ala Ala Thr Gly Phe Ile Ile Asp Pro Ile Ser Gly Gln
        2740                2745                2750

 aca tat tct gtt gaa gat gca gtt ctt aaa gga gtt gtt gac ccc gaa     8601
 Thr Tyr Ser Val Glu Asp Ala Val Leu Lys Gly Val Val Asp Pro Glu
    2755                2760                2765

 ttc aga att agg ctt ctt gag gca gag aag gca gct gtg gga tat tct     8649
 Phe Arg Ile Arg Leu Leu Glu Ala Glu Lys Ala Ala Val Gly Tyr Ser
2770                2775                2780                2785

 tat tct tct aag aca ttg tca gtg ttt caa gct atg gaa aat aga atg     8697
 Tyr Ser Ser Lys Thr Leu Ser Val Phe Gln Ala Met Glu Asn Arg Met
                2790                2795                2800

 ctt gac aga caa aaa ggt aaa cat atc ttg gaa gcc cag att gcc agt     8745
 Leu Asp Arg Gln Lys Gly Lys His Ile Leu Glu Ala Gln Ile Ala Ser
            2805                2810                2815

 ggg ggt gtc att gac cct gtg aga ggc att cgt gtt cct cca gaa att     8793
 Gly Gly Val Ile Asp Pro Val Arg Gly Ile Arg Val Pro Pro Glu Ile
        2820                2825                2830

 gct ctg cag cag ggg ttg ttg aat aat gcc atc tta cag ttt tta cat     8841
 Ala Leu Gln Gln Gly Leu Leu Asn Asn Ala Ile Leu Gln Phe Leu His
    2835                2840                2845

 gag cca tcc agc aac aca aga gtt ttc cct aat ccc aat aac aag caa     8889
 Glu Pro Ser Ser Asn Thr Arg Val Phe Pro Asn Pro Asn Asn Lys Gln
2850                2855                2860                2865

 gct ctg tat tac tca gaa tta ctg cga atg tgt gta ttt gat gta gag     8937
 Ala Leu Tyr Tyr Ser Glu Leu Leu Arg Met Cys Val Phe Asp Val Glu
                2870                2875                2880

 tcc caa tgc ttt ctg ttt cca ttt ggg gag agg aac att tcc aat ctc     8985
 Ser Gln Cys Phe Leu Phe Pro Phe Gly Glu Arg Asn Ile Ser Asn Leu
            2885                2890                2895

 aat gtc aag aaa aca cat aga att tct gta gta gat act aaa aca gga     9033
 Asn Val Lys Lys Thr His Arg Ile Ser Val Val Asp Thr Lys Thr Gly
        2900                2905                2910

 tca gaa ttg acc gtg tat gag gct ttc cag aga aac ctg att gag aaa     9081
 Ser Glu Leu Thr Val Tyr Glu Ala Phe Gln Arg Asn Leu Ile Glu Lys
    2915                2920                2925

 agt ata tat ctt gaa ctt tca ggg cag caa tat cag tgg aag gaa gct     9129
 Ser Ile Tyr Leu Glu Leu Ser Gly Gln Gln Tyr Gln Trp Lys Glu Ala
2930                2935                2940                2945

 atg ttt ttt gaa tcc tat ggg cat tct tct cat atg ctg act gat act     9177
 Met Phe Phe Glu Ser Tyr Gly His Ser Ser His Met Leu Thr Asp Thr
                2950                2955                2960

 aaa aca gga tta cac ttc aat att aat gag gct ata gag cag gga aca     9225
 Lys Thr Gly Leu His Phe Asn Ile Asn Glu Ala Ile Glu Gln Gly Thr
            2965                2970                2975

 att gac aaa gcc ttg gtc aaa aag tat cag gaa ggc ctc atc aca ctt     9273
 Ile Asp Lys Ala Leu Val Lys Lys Tyr Gln Glu Gly Leu Ile Thr Leu
        2980                2985                2990

 aca gaa ctt gct gat tct ttg ctg agc cgg tta gtc ccc aag aaa gat     9321
 Thr Glu Leu Ala Asp Ser Leu Leu Ser Arg Leu Val Pro Lys Lys Asp
    2995                3000                3005

 ttg cac agt cct gtt gca ggg tat tgg ctg act gct agt ggg gaa agg     9369
 Leu His Ser Pro Val Ala Gly Tyr Trp Leu Thr Ala Ser Gly Glu Arg
3010                3015                3020                3025

 atc tct gta cta aaa gcc tcc cgt aga aat ttg gtt gat cgg att act     9417
 Ile Ser Val Leu Lys Ala Ser Arg Arg Asn Leu Val Asp Arg Ile Thr
                3030                3035                3040

 gcc ctc cga tgc ctt gaa gcc caa gtc agt aca ggg ggc ata att gat     9465
 Ala Leu Arg Cys Leu Glu Ala Gln Val Ser Thr Gly Gly Ile Ile Asp
            3045                3050                3055

 cct ctt act ggc aaa aag tac cgg gtg gcc gaa gct ttg cat aga ggc     9513
 Pro Leu Thr Gly Lys Lys Tyr Arg Val Ala Glu Ala Leu His Arg Gly
        3060                3065                3070

 ctg gtt gat gag ggg ttt gcc cag cag ctg cga cag tgt gaa tta gta     9561
 Leu Val Asp Glu Gly Phe Ala Gln Gln Leu Arg Gln Cys Glu Leu Val
    3075                3080                3085

 atc aca ggg att ggc cat ccc atc act aac aaa atg atg tca gtg gtg     9609
 Ile Thr Gly Ile Gly His Pro Ile Thr Asn Lys Met Met Ser Val Val
3090                3095                3100                3105

 gaa gct gtg aat gca aat att ata aat aag gaa atg gga atc cga tgt     9657
 Glu Ala Val Asn Ala Asn Ile Ile Asn Lys Glu Met Gly Ile Arg Cys
                3110                3115                3120

 ttg gaa ttt cag tac ttg aca gga ggg ttg ata gag cca cag gtt cac     9705
 Leu Glu Phe Gln Tyr Leu Thr Gly Gly Leu Ile Glu Pro Gln Val His
            3125                3130                3135

 tct cgg tta tca ata gaa gag gct ctc caa gta ggt att ata gat gtc     9753
 Ser Arg Leu Ser Ile Glu Glu Ala Leu Gln Val Gly Ile Ile Asp Val
        3140                3145                3150

 ctc att gcc aca aaa ctc aaa gat caa aag tca tat gtc aga aat ata     9801
 Leu Ile Ala Thr Lys Leu Lys Asp Gln Lys Ser Tyr Val Arg Asn Ile
    3155                3160                3165

 ata tgc cct cag aca aaa aga aag ttg aca tat aaa gaa gcc tta gaa     9849
 Ile Cys Pro Gln Thr Lys Arg Lys Leu Thr Tyr Lys Glu Ala Leu Glu
3170                3175                3180                3185

 aaa gct gat ttt gat ttc cac aca gga ctt aaa ctg tta gaa gta tct     9897
 Lys Ala Asp Phe Asp Phe His Thr Gly Leu Lys Leu Leu Glu Val Ser
                3190                3195                3200

 gag ccc ctg atg aca gga att tct agc ctc tac tat tct tcc taa         9942
 Glu Pro Leu Met Thr Gly Ile Ser Ser Leu Tyr Tyr Ser Ser 
            3205                3210                3215





      <210> 614
      <211> 9978
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (295)..(9978)

      <400> 614
 cggacggggg cgggggcgcc tggggaggga ggggagagga tcccagccgc cgagtcgcag     60

 cctcgtggct gtctgctgag tcatggcaag cgctccccgc agccctggat cactcgcgta    120

 gcgcggctgg cgcggggtgc gcagccattg ggctgggcgc ggggccgcga gcgccaggca    180

 tgacgcgctg agccgcgctc acccgtgccc gccgtcccgg cgtgcgccca gcgcgggtgc    240

 ctgtgccgcc gccctccagc cccgccgtcg agtcgccctc gcctcgcccg cacc  atg     297
                                                              Met
                                                                1

 atc gcc gcg gct ttc ctc gtc ttg ctg aga ccc tac agc atc caa tgt      345
 Ile Ala Ala Ala Phe Leu Val Leu Leu Arg Pro Tyr Ser Ile Gln Cys
               5                  10                  15

 gcc ctc ttc ctc ttg ttg ctt ctg ctg ggc acc atc gcc acc atc gtc      393
 Ala Leu Phe Leu Leu Leu Leu Leu Leu Gly Thr Ile Ala Thr Ile Val
          20                  25                  30

 ttc ttc tgc tgc tgg cac cgc aag ctc cag aaa ggg agg cat ccg atg      441
 Phe Phe Cys Cys Trp His Arg Lys Leu Gln Lys Gly Arg His Pro Met
      35                  40                  45

 aaa tcg gtc ttc tcg ggt cgt tca aga agc cga gat gct gtt ttg aga      489
 Lys Ser Val Phe Ser Gly Arg Ser Arg Ser Arg Asp Ala Val Leu Arg
  50                  55                  60                  65

 tcg cac cac ttt cgt tct gag gga ttc aga gca agc cct cgg cat ctt      537
 Ser His His Phe Arg Ser Glu Gly Phe Arg Ala Ser Pro Arg His Leu
                  70                  75                  80

 aga aga cga gtt gca gcg gcc gca gct gcc cgt ctg gaa gaa gtg aag      585
 Arg Arg Arg Val Ala Ala Ala Ala Ala Ala Arg Leu Glu Glu Val Lys
              85                  90                  95

 ccc gtg gtg gaa gtt cac cat cag agt gag caa gaa act tca gtg agg      633
 Pro Val Val Glu Val His His Gln Ser Glu Gln Glu Thr Ser Val Arg
         100                 105                 110

 aaa cga aga atc aag aag agc agc cga gtc cag cca gaa ttt tat cac      681
 Lys Arg Arg Ile Lys Lys Ser Ser Arg Val Gln Pro Glu Phe Tyr His
     115                 120                 125

 tct gtt caa ggt gct tca atc agg agg cct agt tcc ggg aac gcg tcc      729
 Ser Val Gln Gly Ala Ser Ile Arg Arg Pro Ser Ser Gly Asn Ala Ser
 130                 135                 140                 145

 tat cgc tgc tct atg tct tcc tct gcg gat ttt tcc gat gag gaa gat      777
 Tyr Arg Cys Ser Met Ser Ser Ser Ala Asp Phe Ser Asp Glu Glu Asp
                 150                 155                 160

 ttc agc cag aaa tct ggc tcc gca tcc cca gct ccg gga gac acc tta      825
 Phe Ser Gln Lys Ser Gly Ser Ala Ser Pro Ala Pro Gly Asp Thr Leu
             165                 170                 175

 ccc tgg aat ttg cct aaa cat gag aga tcg aaa aga aag att caa ggg      873
 Pro Trp Asn Leu Pro Lys His Glu Arg Ser Lys Arg Lys Ile Gln Gly
         180                 185                 190

 ggc tca gtg ctg gac cct gcc gag agg gca gtg ctt cgg ata gca gat      921
 Gly Ser Val Leu Asp Pro Ala Glu Arg Ala Val Leu Arg Ile Ala Asp
     195                 200                 205

 gaa cgg gac aaa gtt cag aag aaa aca ttt aca aaa tgg ata aat cag      969
 Glu Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Gln
 210                 215                 220                 225

 cat ctc atg aag gtt cga aaa cat gtg aat gat ctc tat gaa gac tta     1017
 His Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp Leu
                 230                 235                 240

 agg gat gga cac aat ttg att tct ctt tta gag gtt ctt tca gga gat     1065
 Arg Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp
             245                 250                 255

 acc ttg cca agg gag cga gat ttt ttg aag acc tta cga ttg ccc aga     1113
 Thr Leu Pro Arg Glu Arg Asp Phe Leu Lys Thr Leu Arg Leu Pro Arg
         260                 265                 270

 gaa aaa ggt cgg atg cgt ttt cac aga cta cag aat gta caa att gca     1161
 Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala
     275                 280                 285

 ctt gac tat ttg aaa aga cgc cag gtg aaa tta gtg aat att aga aat     1209
 Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu Val Asn Ile Arg Asn
 290                 295                 300                 305

 gat gac ata aca gat gga aat ccc aaa ttg act ttg gga tta atc tgg     1257
 Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp
                 310                 315                 320

 aca ata att ttg cac ttt cag ata tct gat atc cat gtt act gga gag     1305
 Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile His Val Thr Gly Glu
             325                 330                 335

 tca gag gat atg tct gca aaa gag aga ttg cta ctc tgg acg cag cag     1353
 Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu Leu Trp Thr Gln Gln
         340                 345                 350

 gca aca gag ggt tat gct gga att cgg tgt gaa aat ttc act acc tgc     1401
 Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu Asn Phe Thr Thr Cys
     355                 360                 365

 tgg aga gat gga aaa tta ttt aat gcc atc att cat aaa tac agg ccg     1449
 Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile His Lys Tyr Arg Pro
 370                 375                 380                 385

 gac ctg ata gat atg aat act gtt gct gtt caa agc aac ctt gca aat     1497
 Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln Ser Asn Leu Ala Asn
                 390                 395                 400

 tta gag cat gct ttt tac gta gca gaa aaa att ggt gtt ata aga ctt     1545
 Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile Gly Val Ile Arg Leu
             405                 410                 415

 ctg gac cct gaa gat gtc gat gtc tcc tca cct gat gaa aaa tca gta     1593
 Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro Asp Glu Lys Ser Val
         420                 425                 430

 ata act tac gtg tca tct ctc tat gat gca ttt cct aaa gtc cct gaa     1641
 Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe Pro Lys Val Pro Glu
     435                 440                 445

 ggt ggg gaa ggc att ggt gca aat gat gtt gaa gtc aaa tgg att gaa     1689
 Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu Val Lys Trp Ile Glu
 450                 455                 460                 465

 tac cag aat atg gtg aac tac ctc atc caa tgg att aga cac cat gtg     1737
 Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp Ile Arg His His Val
                 470                 475                 480

 acc aca atg tct gag aga aca ttt cct aat aat cct gta gaa ctg aag     1785
 Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn Pro Val Glu Leu Lys
             485                 490                 495

 gca ctt tat aat cag tat tta cag ttt aaa gaa aca gaa att cca cca     1833
 Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu Thr Glu Ile Pro Pro
         500                 505                 510

 aag gag aca gaa aaa tca aaa att aaa cga cta tat aaa tta tta gag     1881
 Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu Tyr Lys Leu Leu Glu
     515                 520                 525

 aaa gtt ttt tgt ttt ctc aag att tgg ata gaa ttt gga cgc atc aag     1929
 Lys Val Phe Cys Phe Leu Lys Ile Trp Ile Glu Phe Gly Arg Ile Lys
 530                 535                 540                 545

 ctc ctt caa ggt tat cat cca aat gac ata gaa aaa gag tgg ggg aaa     1977
 Leu Leu Gln Gly Tyr His Pro Asn Asp Ile Glu Lys Glu Trp Gly Lys
                 550                 555                 560

 ctc att att gcc atg cta gag aga gag aag gcc ctt cgt cca gaa gta     2025
 Leu Ile Ile Ala Met Leu Glu Arg Glu Lys Ala Leu Arg Pro Glu Val
             565                 570                 575

 gaa agg tta gaa atg ttg caa cag att gcc aac aga gtt cag agg gac     2073
 Glu Arg Leu Glu Met Leu Gln Gln Ile Ala Asn Arg Val Gln Arg Asp
         580                 585                 590

 agt gtc atc tgt gaa gac aaa ctg att ctt gct gga aat gct ctt cag     2121
 Ser Val Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly Asn Ala Leu Gln
     595                 600                 605

 tct gat tct aaa aga tta gaa tca gga gtg cag ttt cag aat gaa gca     2169
 Ser Asp Ser Lys Arg Leu Glu Ser Gly Val Gln Phe Gln Asn Glu Ala
 610                 615                 620                 625

 gaa att gct ggg tat ata ctt gaa tgt gag aac ctt tta cgc cag cat     2217
 Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu Leu Arg Gln His
                 630                 635                 640

 gta att gat gta cag att ctt att gat gga aaa tac tac cag gca gat     2265
 Val Ile Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr Tyr Gln Ala Asp
             645                 650                 655

 caa ttg gta cag agg gtt gca aaa ctg cgt gac gaa att atg gcc tta     2313
 Gln Leu Val Gln Arg Val Ala Lys Leu Arg Asp Glu Ile Met Ala Leu
         660                 665                 670

 agg aac gaa tgt tct tct gtg tac agc aaa gga cgc ata ctg aca aca     2361
 Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg Ile Leu Thr Thr
     675                 680                 685

 gaa cag aca aag ctc atg ata tca gga atc act caa agt tta aac tca     2409
 Glu Gln Thr Lys Leu Met Ile Ser Gly Ile Thr Gln Ser Leu Asn Ser
 690                 695                 700                 705

 gga ttt gca cag acc tta cac cct agt ctg acc tca ggg ctg acc cag     2457
 Gly Phe Ala Gln Thr Leu His Pro Ser Leu Thr Ser Gly Leu Thr Gln
                 710                 715                 720

 agt tta aca cct tcc cta acc tct tct agt atg act tct ggc ctg tca     2505
 Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser Met Thr Ser Gly Leu Ser
             725                 730                 735

 tca ggg atg act tcc cgc ctg act cca tct gtc act cca gct tat aca     2553
 Ser Gly Met Thr Ser Arg Leu Thr Pro Ser Val Thr Pro Ala Tyr Thr
         740                 745                 750

 cct ggt ttc cca tca gga tta gtt cca aat ttc agt tca gga gta gag     2601
 Pro Gly Phe Pro Ser Gly Leu Val Pro Asn Phe Ser Ser Gly Val Glu
     755                 760                 765

 cca aat tca ttg caa act ttg aag ttg atg cag atc cga aaa ccc ctt     2649
 Pro Asn Ser Leu Gln Thr Leu Lys Leu Met Gln Ile Arg Lys Pro Leu
 770                 775                 780                 785

 cta aag tct tct ttg ctg gat caa aat tta aca gaa gaa gaa atc aat     2697
 Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu Thr Glu Glu Glu Ile Asn
                 790                 795                 800

 atg aaa ttt gtt cag gat ctt ttg aat tgg gtt gat gag atg cag gta     2745
 Met Lys Phe Val Gln Asp Leu Leu Asn Trp Val Asp Glu Met Gln Val
             805                 810                 815

 caa ctg gac cgc act gag tgg ggc tca gat ttg cca agt gtt gaa agc     2793
 Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp Leu Pro Ser Val Glu Ser
         820                 825                 830

 cat tta gaa aat cat aaa aat gtt cat aga gct att gaa gaa ttt gaa     2841
 His Leu Glu Asn His Lys Asn Val His Arg Ala Ile Glu Glu Phe Glu
     835                 840                 845

 tct agt ctc aaa gaa gct aaa atc agt gag att caa atg aca gca cct     2889
 Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu Ile Gln Met Thr Ala Pro
 850                 855                 860                 865

 ctt aaa ctg act tat gca gaa aag ttg cac aga tta gag agt cag tat     2937
 Leu Lys Leu Thr Tyr Ala Glu Lys Leu His Arg Leu Glu Ser Gln Tyr
                 870                 875                 880

 gca aaa ctc ttg ttt tcc tta cta aag aat aca tcc agg aat caa gaa     2985
 Ala Lys Leu Leu Phe Ser Leu Leu Lys Asn Thr Ser Arg Asn Gln Glu
             885                 890                 895

 cgg cac ctt gat aca ctc cat aat ttt gta agt cgt gcg act aat gaa     3033
 Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn Glu
         900                 905                 910

 ctt att tgg ttg aat gaa aaa gaa gag gag gaa gtt gct tat gac tgg     3081
 Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp Trp
     915                 920                 925

 agt gag aga aac acc aac ata gct agg aaa aaa gat tat cat gct gaa     3129
 Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala Glu
 930                 935                 940                 945

 tta atg aga gaa ctt gat caa aag gaa gaa aat att aaa tca gtt cag     3177
 Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val Gln
                 950                 955                 960

 gag ata gca gag cag cta ctt cta gaa aat cat cca gcc cgg tta act     3225
 Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu Thr
             965                 970                 975

 att gag gta aag ctg gaa agt gta atg gtg ttg gtt gaa tat gcc tac     3273
 Ile Glu Val Lys Leu Glu Ser Val Met Val Leu Val Glu Tyr Ala Tyr
         980                 985                 990

 aga gcg gca atg cag acg cag tgg agc tgg atc tta cag ctc tgc cag     3321
 Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile Leu Gln Leu Cys Gln
     995                1000                1005

 tgt gtg gag cag cac ata aag gag aac aca gcg tat ttc gag ttt ttc     3369
 Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala Tyr Phe Glu Phe Phe
1010                1015                1020                1025

 aat gat gcc aaa gaa gct act gat tac tta agg aat cta aaa gat gcc     3417
 Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg Asn Leu Lys Asp Ala
                1030                1035                1040

 att cag cgg aag tac agc tgt gat aga tca agc agc att cac aag cta     3465
 Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser Ser Ile His Lys Leu
            1045                1050                1055

 gaa gac ctt gtt cag gaa tca atg gaa gag aaa gaa gaa ctt ctg cag     3513
 Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys Glu Glu Leu Leu Gln
        1060                1065                1070

 tac aaa agc act ata gca aac cta atg gga aaa gca aaa aca ata att     3561
 Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys Ala Lys Thr Ile Ile
    1075                1080                1085

 caa ctg aag cca agg aat tct gac tgt cca ctc aaa act tct att ccg     3609
 Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu Lys Thr Ser Ile Pro
1090                1095                1100                1105

 atc aaa gct atc tgt gac tac aga caa att gag ata acc att tac aaa     3657
 Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu Ile Thr Ile Tyr Lys
                1110                1115                1120

 gac gat gaa tgt gtt ttg gcg aat aac tct cat cgt gct aaa tgg aag     3705
 Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His Arg Ala Lys Trp Lys
            1125                1130                1135

 gtc att agt cct act ggg aat gag gct atg gtc cca tct gtg tgc ttc     3753
 Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val Pro Ser Val Cys Phe
        1140                1145                1150

 acc gtt cct cca cca aac aaa gaa gcg gtg gac ctt gcc aac aga att     3801
 Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp Leu Ala Asn Arg Ile
    1155                1160                1165

 gag caa cag tat cag aat gtc ctg act ctt tgg cat gag tct cac ata     3849
 Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp His Glu Ser His Ile
1170                1175                1180                1185

 aac atg aag agt gta gta tcc tgg cat tat ctc atc aat gaa att gat     3897
 Asn Met Lys Ser Val Val Ser Trp His Tyr Leu Ile Asn Glu Ile Asp
                1190                1195                1200

 aga att cga gct agc aat gtg gct tca gta agt atg aat ctg ata aag     3945
 Arg Ile Arg Ala Ser Asn Val Ala Ser Val Ser Met Asn Leu Ile Lys
            1205                1210                1215

 aca atg cta cct ggt gaa cat cag caa gtt cta agt aat cta caa tct     3993
 Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser
        1220                1225                1230

 cgt ttt gaa gat ttt ctg gaa gat agc cag gaa tcc caa gtc ttt tca     4041
 Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser
    1235                1240                1245

 ggc tca gat ata aca caa ctg gaa aag gag gtt aat gta tgt aag cag     4089
 Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln
1250                1255                1260                1265

 tat tat caa gaa ctt ctt aaa tct gca gaa aga gag gag caa gag gaa     4137
 Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu
                1270                1275                1280

 tca gtt tat aat ctc tac atc tct gaa gtt cga aac att aga ctt cgg     4185
 Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg
            1285                1290                1295

 tta gag aac tgt gaa gat cgg ctg att aga cag att cga act ccc ctg     4233
 Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu
        1300                1305                1310

 gaa aga gat gat ttg cat gaa agt gtg ttc aga atc aca gaa cag gag     4281
 Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu
    1315                1320                1325

 aaa cta aag aaa gag ctg gaa cga ctt aaa gat gat ttg gga aca atc     4329
 Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile
1330                1335                1340                1345

 aca aat aag tgt gag gag ttt ttc agt caa gca gca gcc tct tca tca     4377
 Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser
                1350                1355                1360

 gtc cct acc cta cga tca gag ctt aat gtg gtc ctt cag aac atg aac     4425
 Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn
            1365                1370                1375

 caa gtc tat tct atg tct tcc act tac ata gat aag tat gta act gct     4473
 Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Tyr Val Thr Ala
        1380                1385                1390

 atc tca ata tat aaa ggc tat tgt tta att tcc ttt tta agg ttg aaa     4521
 Ile Ser Ile Tyr Lys Gly Tyr Cys Leu Ile Ser Phe Leu Arg Leu Lys
    1395                1400                1405

 act gtt aac ttg gtg tta aaa aac act caa gct gca gaa gcc ctc gta     4569
 Thr Val Asn Leu Val Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val
1410                1415                1420                1425

 aaa ctc tat gaa act aaa ctg tgt gaa gaa gaa gca gtt ata gct gac     4617
 Lys Leu Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp
                1430                1435                1440

 aag aat aat att gag aat cta ata agt act tta aag caa tgg aga tct     4665
 Lys Asn Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser
            1445                1450                1455

 gaa gta gat gaa aag aga cag gta ttc cat gcc tta gag gat gag ttg     4713
 Glu Val Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu
        1460                1465                1470

 cag aaa gct aaa gcc atc agt gat gaa atg ttt aaa acg tat aaa gaa     4761
 Gln Lys Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu
    1475                1480                1485

 cgg gac ctt gat ttt gac tgg cac aaa gaa aaa gca gat caa tta gtt     4809
 Arg Asp Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val
1490                1495                1500                1505

 gaa agg tgg caa aat gtt cat gtg cag att gac aac agg tta cgg gac     4857
 Glu Arg Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp
                1510                1515                1520

 tta gag ggc att ggc aaa tca ctg aag tac tac aga gac act tac cat     4905
 Leu Glu Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His
            1525                1530                1535

 cct tta gat gat tgg atc cag cag gtt gaa act act cag aga aag att     4953
 Pro Leu Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile
        1540                1545                1550

 cag gaa aat cag cct gaa aat agt aaa acc cta gcc aca cag ttg aat     5001
 Gln Glu Asn Gln Pro Glu Asn Ser Lys Thr Leu Ala Thr Gln Leu Asn
    1555                1560                1565

 caa cag aag atg ctg gtg tcc gaa ata gaa atg aaa cag agc aaa atg     5049
 Gln Gln Lys Met Leu Val Ser Glu Ile Glu Met Lys Gln Ser Lys Met
1570                1575                1580                1585

 gac gag tgt caa aaa tat gca gaa cag tac tca gct aca gtg aag gac     5097
 Asp Glu Cys Gln Lys Tyr Ala Glu Gln Tyr Ser Ala Thr Val Lys Asp
                1590                1595                1600

 tat gaa tta caa aca atg acc tac cgg gcc atg gta gat tca caa caa     5145
 Tyr Glu Leu Gln Thr Met Thr Tyr Arg Ala Met Val Asp Ser Gln Gln
            1605                1610                1615

 aaa tct cca gtg aaa cgc cga aga atg cag agt tca gca gat ctc att     5193
 Lys Ser Pro Val Lys Arg Arg Arg Met Gln Ser Ser Ala Asp Leu Ile
        1620                1625                1630

 att caa gag ttc atg gac cta agg act cga tat act gcc ctg gtc act     5241
 Ile Gln Glu Phe Met Asp Leu Arg Thr Arg Tyr Thr Ala Leu Val Thr
    1635                1640                1645

 ctc atg aca caa tat att aaa ttt gct ggt gat tca ttg aag agg ctg     5289
 Leu Met Thr Gln Tyr Ile Lys Phe Ala Gly Asp Ser Leu Lys Arg Leu
1650                1655                1660                1665

 gaa gag gag gag gta atc att aac agt gag cac cct gta aat ata aag     5337
 Glu Glu Glu Glu Val Ile Ile Asn Ser Glu His Pro Val Asn Ile Lys
                1670                1675                1680

 gag cta gag att aaa agg tgt aag gag act tct gaa cat ggg gca tat     5385
 Glu Leu Glu Ile Lys Arg Cys Lys Glu Thr Ser Glu His Gly Ala Tyr
            1685                1690                1695

 tca gat ctg ctt cag cgt cag aag gca aca gtg ctt gag aat agc aaa     5433
 Ser Asp Leu Leu Gln Arg Gln Lys Ala Thr Val Leu Glu Asn Ser Lys
        1700                1705                1710

 ctt aca gga aag ata agt gag ttg gaa aga atg gta gct gaa cta aag     5481
 Leu Thr Gly Lys Ile Ser Glu Leu Glu Arg Met Val Ala Glu Leu Lys
    1715                1720                1725

 aaa caa aag tcc cga gta gag gaa gaa ctt ccg aag gtc agg gag gct     5529
 Lys Gln Lys Ser Arg Val Glu Glu Glu Leu Pro Lys Val Arg Glu Ala
1730                1735                1740                1745

 gca gaa aat gaa ttg aga aag cag cag aga aat gta gaa gat atc tct     5577
 Ala Glu Asn Glu Leu Arg Lys Gln Gln Arg Asn Val Glu Asp Ile Ser
                1750                1755                1760

 ctg cag aag ata agg gct gaa agt gaa gcc aag cag tac cgc agg gaa     5625
 Leu Gln Lys Ile Arg Ala Glu Ser Glu Ala Lys Gln Tyr Arg Arg Glu
            1765                1770                1775

 ctt gaa acc att gtg aga gag aag gaa gcc gct gaa aga gaa ctg gag     5673
 Leu Glu Thr Ile Val Arg Glu Lys Glu Ala Ala Glu Arg Glu Leu Glu
        1780                1785                1790

 cgg gtg agg cag ctc acc ata gag gcc gag gct aaa aga gct gcc gtg     5721
 Arg Val Arg Gln Leu Thr Ile Glu Ala Glu Ala Lys Arg Ala Ala Val
    1795                1800                1805

 gaa gag aac ctc ctg aat ttt cgc aat cag ttg gag gaa aac acc ttt     5769
 Glu Glu Asn Leu Leu Asn Phe Arg Asn Gln Leu Glu Glu Asn Thr Phe
1810                1815                1820                1825

 acc aga cga aca ctg gaa gat cat ctt aaa aga aaa gat tta agt ctc     5817
 Thr Arg Arg Thr Leu Glu Asp His Leu Lys Arg Lys Asp Leu Ser Leu
                1830                1835                1840

 aat gat ttg gag caa caa aaa aat aaa tta atg gaa gaa tta aga aga     5865
 Asn Asp Leu Glu Gln Gln Lys Asn Lys Leu Met Glu Glu Leu Arg Arg
            1845                1850                1855

 aag aga gac aat gag gaa gaa ctc ttg aag ctg ata aag cag atg gaa     5913
 Lys Arg Asp Asn Glu Glu Glu Leu Leu Lys Leu Ile Lys Gln Met Glu
        1860                1865                1870

 aaa gac ctt gca ttt cag aaa cag gta gca gag aaa cag ttg aaa gaa     5961
 Lys Asp Leu Ala Phe Gln Lys Gln Val Ala Glu Lys Gln Leu Lys Glu
    1875                1880                1885

 aag cag aaa att gaa ttg gaa gca aga aga aaa ata act gaa att cag     6009
 Lys Gln Lys Ile Glu Leu Glu Ala Arg Arg Lys Ile Thr Glu Ile Gln
1890                1895                1900                1905

 tat aca tgt aga gaa aat gca ttg cca gtg tgt ccg atc aca cag gct     6057
 Tyr Thr Cys Arg Glu Asn Ala Leu Pro Val Cys Pro Ile Thr Gln Ala
                1910                1915                1920

 aca tca tgc agg gca gta acg ggt ctc cag caa gaa cat gac aag cag     6105
 Thr Ser Cys Arg Ala Val Thr Gly Leu Gln Gln Glu His Asp Lys Gln
            1925                1930                1935

 aaa gca gaa gaa ctc aaa cag cag gta gat gaa cta aca gct gcc aat     6153
 Lys Ala Glu Glu Leu Lys Gln Gln Val Asp Glu Leu Thr Ala Ala Asn
        1940                1945                1950

 aga aag gct gaa caa gac atg aga gag ctg aca tat gaa ctt aat gcc     6201
 Arg Lys Ala Glu Gln Asp Met Arg Glu Leu Thr Tyr Glu Leu Asn Ala
    1955                1960                1965

 ctc cag ctt gaa aaa acg tca tct gag gaa aag gct cgt ttg cta aaa     6249
 Leu Gln Leu Glu Lys Thr Ser Ser Glu Glu Lys Ala Arg Leu Leu Lys
1970                1975                1980                1985

 gat aaa cta gat gaa aca aat aat aca ctc aga tgc ctt aag ttg gag     6297
 Asp Lys Leu Asp Glu Thr Asn Asn Thr Leu Arg Cys Leu Lys Leu Glu
                1990                1995                2000

 ctg gaa agg aag gat cag gcg gag aaa ggg tat tct caa caa ctc aga     6345
 Leu Glu Arg Lys Asp Gln Ala Glu Lys Gly Tyr Ser Gln Gln Leu Arg
            2005                2010                2015

 gag ctt ggt agg caa ttg aat caa acc aca ggt aaa gct gaa gaa gcc     6393
 Glu Leu Gly Arg Gln Leu Asn Gln Thr Thr Gly Lys Ala Glu Glu Ala
        2020                2025                2030

 atg caa gaa gct agt gat ctc aag aaa ata aag cgc aat tat cag tta     6441
 Met Gln Glu Ala Ser Asp Leu Lys Lys Ile Lys Arg Asn Tyr Gln Leu
    2035                2040                2045

 gaa tta gaa tct ctt aat cat gaa aaa ggg aaa cta caa aga gaa gta     6489
 Glu Leu Glu Ser Leu Asn His Glu Lys Gly Lys Leu Gln Arg Glu Val
2050                2055                2060                2065

 gac aga atc aca agg gca cat gct gta gct gag aag aat att cag cat     6537
 Asp Arg Ile Thr Arg Ala His Ala Val Ala Glu Lys Asn Ile Gln His
                2070                2075                2080

 tta aat tca caa att cat tct ttt cga gat gag aaa gaa tta gaa aga     6585
 Leu Asn Ser Gln Ile His Ser Phe Arg Asp Glu Lys Glu Leu Glu Arg
            2085                2090                2095

 cta caa atc tgc cag aga aaa tca gat cat cta aaa gaa caa ttt gag     6633
 Leu Gln Ile Cys Gln Arg Lys Ser Asp His Leu Lys Glu Gln Phe Glu
        2100                2105                2110

 aaa agc cat gag cag ttg ctt caa aat atc aaa gct gaa aaa gaa aat     6681
 Lys Ser His Glu Gln Leu Leu Gln Asn Ile Lys Ala Glu Lys Glu Asn
    2115                2120                2125

 aat gat aaa atc caa agg ctc aat gaa gaa ttg gag aaa agt aat gag     6729
 Asn Asp Lys Ile Gln Arg Leu Asn Glu Glu Leu Glu Lys Ser Asn Glu
2130                2135                2140                2145

 tgt gca gag atg cta aaa caa aaa gta gag gag ctt act agg cag aat     6777
 Cys Ala Glu Met Leu Lys Gln Lys Val Glu Glu Leu Thr Arg Gln Asn
                2150                2155                2160

 aat gaa acc aaa tta atg atg cag aga att cag gca gaa tca gag aat     6825
 Asn Glu Thr Lys Leu Met Met Gln Arg Ile Gln Ala Glu Ser Glu Asn
            2165                2170                2175

 ata gtt tta gag aaa caa act atc cag caa aga tgt gaa gca ctg aaa     6873
 Ile Val Leu Glu Lys Gln Thr Ile Gln Gln Arg Cys Glu Ala Leu Lys
        2180                2185                2190

 att cag gca gat ggt ttt aaa gat cag cta cgc agc aca aat gaa cac     6921
 Ile Gln Ala Asp Gly Phe Lys Asp Gln Leu Arg Ser Thr Asn Glu His
    2195                2200                2205

 ttg cat aaa cag aca aaa aca gag cag gat ttt caa aga aaa att aaa     6969
 Leu His Lys Gln Thr Lys Thr Glu Gln Asp Phe Gln Arg Lys Ile Lys
2210                2215                2220                2225

 tgc cta gaa gaa gac ctg gcg aaa agt caa aat ttg gta agt gaa ttt     7017
 Cys Leu Glu Glu Asp Leu Ala Lys Ser Gln Asn Leu Val Ser Glu Phe
                2230                2235                2240

 aag caa aag tgt gac caa cag aac att atc atc cag aat acc aag aaa     7065
 Lys Gln Lys Cys Asp Gln Gln Asn Ile Ile Ile Gln Asn Thr Lys Lys
            2245                2250                2255

 gaa gtt aga aat ctg aat gcg gaa ctg aat gct tcc aaa gaa gag aag     7113
 Glu Val Arg Asn Leu Asn Ala Glu Leu Asn Ala Ser Lys Glu Glu Lys
        2260                2265                2270

 cga cgc ggg gag cag aaa gtt cag cta caa caa gct cag gtg caa gag     7161
 Arg Arg Gly Glu Gln Lys Val Gln Leu Gln Gln Ala Gln Val Gln Glu
    2275                2280                2285

 tta aat aac agg ttg aaa aaa gta caa gac gaa tta cac tta aag acc     7209
 Leu Asn Asn Arg Leu Lys Lys Val Gln Asp Glu Leu His Leu Lys Thr
2290                2295                2300                2305

 ata gag gag cag atg acc cac aga aag atg gtt ctg ttt cag gaa gaa     7257
 Ile Glu Glu Gln Met Thr His Arg Lys Met Val Leu Phe Gln Glu Glu
                2310                2315                2320

 tct ggt aaa ttc aaa caa tca gca gag gag ttt cgg aag aag atg gaa     7305
 Ser Gly Lys Phe Lys Gln Ser Ala Glu Glu Phe Arg Lys Lys Met Glu
            2325                2330                2335

 aaa tta atg gag tcc aaa gtc atc act gaa aat gat att tca ggc att     7353
 Lys Leu Met Glu Ser Lys Val Ile Thr Glu Asn Asp Ile Ser Gly Ile
        2340                2345                2350

 agg ctt gac ttt gtg tct ctt caa caa gaa aac tct aga gcc caa gaa     7401
 Arg Leu Asp Phe Val Ser Leu Gln Gln Glu Asn Ser Arg Ala Gln Glu
    2355                2360                2365

 aat gct aag ctt tgt gaa aca aac att aaa gaa ctt gaa aga cag ctt     7449
 Asn Ala Lys Leu Cys Glu Thr Asn Ile Lys Glu Leu Glu Arg Gln Leu
2370                2375                2380                2385

 caa cag tat cgt gaa caa atg cag caa ggg cag cac atg gaa gca aat     7497
 Gln Gln Tyr Arg Glu Gln Met Gln Gln Gly Gln His Met Glu Ala Asn
                2390                2395                2400

 cat tac caa aaa tgt cag aaa ctt gag gat gag ctg ata gcc cag aag     7545
 His Tyr Gln Lys Cys Gln Lys Leu Glu Asp Glu Leu Ile Ala Gln Lys
            2405                2410                2415

 cgt gag gtt gaa aac ctg aag caa aaa atg gac caa cag atc aaa gag     7593
 Arg Glu Val Glu Asn Leu Lys Gln Lys Met Asp Gln Gln Ile Lys Glu
        2420                2425                2430

 cat gaa cat caa tta gtt ttg ctc cag tgt gaa att caa aaa aag agc     7641
 His Glu His Gln Leu Val Leu Leu Gln Cys Glu Ile Gln Lys Lys Ser
    2435                2440                2445

 aca gcc aaa gac tgt acc ttc aaa cca gat ttt gag atg aca gtg aag     7689
 Thr Ala Lys Asp Cys Thr Phe Lys Pro Asp Phe Glu Met Thr Val Lys
2450                2455                2460                2465

 gag tgc cag cac tct gga gag ctg tcc tct aga aac act gga cac ctt     7737
 Glu Cys Gln His Ser Gly Glu Leu Ser Ser Arg Asn Thr Gly His Leu
                2470                2475                2480

 cac cca aca ccc aga tcc cct ctg ttg aga tgg act caa gaa cca cag     7785
 His Pro Thr Pro Arg Ser Pro Leu Leu Arg Trp Thr Gln Glu Pro Gln
            2485                2490                2495

 cca ttg gaa gag aag tgg cag cat cgg gtt gtt gaa cag ata ccc aaa     7833
 Pro Leu Glu Glu Lys Trp Gln His Arg Val Val Glu Gln Ile Pro Lys
        2500                2505                2510

 gaa gtc caa ttc cag cca cca ggg gct cca ctc gag aaa gag aaa agc     7881
 Glu Val Gln Phe Gln Pro Pro Gly Ala Pro Leu Glu Lys Glu Lys Ser
    2515                2520                2525

 cag cag tgt tac tct gag tac ttt tct cag aca agc acc gag tta cag     7929
 Gln Gln Cys Tyr Ser Glu Tyr Phe Ser Gln Thr Ser Thr Glu Leu Gln
2530                2535                2540                2545

 ata act ttt gat gag aca aac ccc att aca aga ctg tct gaa att gag     7977
 Ile Thr Phe Asp Glu Thr Asn Pro Ile Thr Arg Leu Ser Glu Ile Glu
                2550                2555                2560

 aag ata aga gac caa gcc ctg aac aat tct aga cca cct gtt agg tat     8025
 Lys Ile Arg Asp Gln Ala Leu Asn Asn Ser Arg Pro Pro Val Arg Tyr
            2565                2570                2575

 caa gat aac gca tgt gaa atg gaa ctg gtg aag gtt ttg aca ccc tta     8073
 Gln Asp Asn Ala Cys Glu Met Glu Leu Val Lys Val Leu Thr Pro Leu
        2580                2585                2590

 gag ata gct aag aac aag cag tat gat atg cat aca gaa gtc aca aca     8121
 Glu Ile Ala Lys Asn Lys Gln Tyr Asp Met His Thr Glu Val Thr Thr
    2595                2600                2605

 tta aaa caa gaa aag aac cca gtt ccc agt gct gaa gaa tgg atg ctt     8169
 Leu Lys Gln Glu Lys Asn Pro Val Pro Ser Ala Glu Glu Trp Met Leu
2610                2615                2620                2625

 gaa ggg tgc aga gca tct ggt gga ctc aag aaa ggg gat ttc ctt aag     8217
 Glu Gly Cys Arg Ala Ser Gly Gly Leu Lys Lys Gly Asp Phe Leu Lys
                2630                2635                2640

 aag ggc tta gaa cca gag acc ttc cag aac ttt gat ggt gat cat gca     8265
 Lys Gly Leu Glu Pro Glu Thr Phe Gln Asn Phe Asp Gly Asp His Ala
            2645                2650                2655

 tgt tca gtc agg gat gat gaa ttt aaa ttc caa ggg ctt agg cac act     8313
 Cys Ser Val Arg Asp Asp Glu Phe Lys Phe Gln Gly Leu Arg His Thr
        2660                2665                2670

 gtg act gcc agg cag ttg gtg gaa gct aag ctt ctg gac atg aga aca     8361
 Val Thr Ala Arg Gln Leu Val Glu Ala Lys Leu Leu Asp Met Arg Thr
    2675                2680                2685

 att gag cag ctg cga ctc ggt ctt aag act gtt gaa gaa gtt cag aaa     8409
 Ile Glu Gln Leu Arg Leu Gly Leu Lys Thr Val Glu Glu Val Gln Lys
2690                2695                2700                2705

 act ctt aac aag ttt ctg acg aaa gcc acc tca att gca ggg ctt tac     8457
 Thr Leu Asn Lys Phe Leu Thr Lys Ala Thr Ser Ile Ala Gly Leu Tyr
                2710                2715                2720

 cta gaa tct aca aaa gaa aag att tca ttt gcc tca gcg gcc gag aga     8505
 Leu Glu Ser Thr Lys Glu Lys Ile Ser Phe Ala Ser Ala Ala Glu Arg
            2725                2730                2735

 atc ata ata gac aaa atg gtg gct ttg gca ttt tta gaa gct cag gct     8553
 Ile Ile Ile Asp Lys Met Val Ala Leu Ala Phe Leu Glu Ala Gln Ala
        2740                2745                2750

 gca aca ggt ttt ata att gat ccc att tca ggt cag aca tat tct gtt     8601
 Ala Thr Gly Phe Ile Ile Asp Pro Ile Ser Gly Gln Thr Tyr Ser Val
    2755                2760                2765

 gaa gat gca gtt ctt aaa gga gtt gtt gac ccc gaa ttc aga att agg     8649
 Glu Asp Ala Val Leu Lys Gly Val Val Asp Pro Glu Phe Arg Ile Arg
2770                2775                2780                2785

 ctt ctt gag gca gag aag gca gct gtg gga tat tct tat tct tct aag     8697
 Leu Leu Glu Ala Glu Lys Ala Ala Val Gly Tyr Ser Tyr Ser Ser Lys
                2790                2795                2800

 aca ttg tca gtg ttt caa gct atg gaa aat aga atg ctt gac aga caa     8745
 Thr Leu Ser Val Phe Gln Ala Met Glu Asn Arg Met Leu Asp Arg Gln
            2805                2810                2815

 aaa ggt aaa cat atc ttg gaa gcc cag att gcc agt ggg ggt gtc att     8793
 Lys Gly Lys His Ile Leu Glu Ala Gln Ile Ala Ser Gly Gly Val Ile
        2820                2825                2830

 gac cct gtg aga ggc att cgt gtt cct cca gaa att gct ctg cag cag     8841
 Asp Pro Val Arg Gly Ile Arg Val Pro Pro Glu Ile Ala Leu Gln Gln
    2835                2840                2845

 ggg ttg ttg aat aat gcc atc tta cag ttt tta cat gag cca tcc agc     8889
 Gly Leu Leu Asn Asn Ala Ile Leu Gln Phe Leu His Glu Pro Ser Ser
2850                2855                2860                2865

 aac aca aga gtt ttc cct aat ccc aat aac aag caa gct ctg tat tac     8937
 Asn Thr Arg Val Phe Pro Asn Pro Asn Asn Lys Gln Ala Leu Tyr Tyr
                2870                2875                2880

 tca gaa tta ctg cga atg tgt gta ttt gat gta gag tcc caa tgc ttt     8985
 Ser Glu Leu Leu Arg Met Cys Val Phe Asp Val Glu Ser Gln Cys Phe
            2885                2890                2895

 ctg ttt cca ttt ggg gag agg aac att tcc aat ctc aat gtc aag aaa     9033
 Leu Phe Pro Phe Gly Glu Arg Asn Ile Ser Asn Leu Asn Val Lys Lys
        2900                2905                2910

 aca cat aga att tct gta gta gat act aaa aca gga tca gaa ttg acc     9081
 Thr His Arg Ile Ser Val Val Asp Thr Lys Thr Gly Ser Glu Leu Thr
    2915                2920                2925

 gtg tat gag gct ttc cag aga aac ctg att gag aaa agt ata tat ctt     9129
 Val Tyr Glu Ala Phe Gln Arg Asn Leu Ile Glu Lys Ser Ile Tyr Leu
2930                2935                2940                2945

 gaa ctt tca ggg cag caa tat cag tgg aag gaa gct atg ttt ttt gaa     9177
 Glu Leu Ser Gly Gln Gln Tyr Gln Trp Lys Glu Ala Met Phe Phe Glu
                2950                2955                2960

 tcc tat ggg cat tct tct cat atg ctg act gat act aaa aca gga tta     9225
 Ser Tyr Gly His Ser Ser His Met Leu Thr Asp Thr Lys Thr Gly Leu
            2965                2970                2975

 cac ttc aat att aat gag gct ata gag cag gga aca att gac aaa gcc     9273
 His Phe Asn Ile Asn Glu Ala Ile Glu Gln Gly Thr Ile Asp Lys Ala
        2980                2985                2990

 ttg gtc aaa aag tat cag gaa ggc ctc atc aca ctt aca gaa ctt gct     9321
 Leu Val Lys Lys Tyr Gln Glu Gly Leu Ile Thr Leu Thr Glu Leu Ala
    2995                3000                3005

 gat tct ttg ctg agc cgg tta gtc ccc aag aaa gat ttg cac agt cct     9369
 Asp Ser Leu Leu Ser Arg Leu Val Pro Lys Lys Asp Leu His Ser Pro
3010                3015                3020                3025

 gtt gca ggg tat tgg ctg act gct agt ggg gaa agg atc tct gta cta     9417
 Val Ala Gly Tyr Trp Leu Thr Ala Ser Gly Glu Arg Ile Ser Val Leu
                3030                3035                3040

 aaa gcc tcc cgt aga aat ttg gtt gat cgg att act gcc ctc cga tgc     9465
 Lys Ala Ser Arg Arg Asn Leu Val Asp Arg Ile Thr Ala Leu Arg Cys
            3045                3050                3055

 ctt gaa gcc caa gtc agt aca ggg ggc ata att gat cct ctt act ggc     9513
 Leu Glu Ala Gln Val Ser Thr Gly Gly Ile Ile Asp Pro Leu Thr Gly
        3060                3065                3070

 aaa aag tac cgg gtg gcc gaa gct ttg cat aga ggc ctg gtt gat gag     9561
 Lys Lys Tyr Arg Val Ala Glu Ala Leu His Arg Gly Leu Val Asp Glu
    3075                3080                3085

 ggg ttt gcc cag cag ctg cga cag tgt gaa tta gta atc aca ggg att     9609
 Gly Phe Ala Gln Gln Leu Arg Gln Cys Glu Leu Val Ile Thr Gly Ile
3090                3095                3100                3105

 ggc cat ccc atc act aac aaa atg atg tca gtg gtg gaa gct gtg aat     9657
 Gly His Pro Ile Thr Asn Lys Met Met Ser Val Val Glu Ala Val Asn
                3110                3115                3120

 gca aat att ata aat aag gaa atg gga atc cga tgt ttg gaa ttt cag     9705
 Ala Asn Ile Ile Asn Lys Glu Met Gly Ile Arg Cys Leu Glu Phe Gln
            3125                3130                3135

 tac ttg aca gga ggg ttg ata gag cca cag gtt cac tct cgg tta tca     9753
 Tyr Leu Thr Gly Gly Leu Ile Glu Pro Gln Val His Ser Arg Leu Ser
        3140                3145                3150

 ata gaa gag gct ctc caa gta ggt att ata gat gtc ctc att gcc aca     9801
 Ile Glu Glu Ala Leu Gln Val Gly Ile Ile Asp Val Leu Ile Ala Thr
    3155                3160                3165

 aaa ctc aaa gat caa aag tca tat gtc aga aat ata ata tgc cct cag     9849
 Lys Leu Lys Asp Gln Lys Ser Tyr Val Arg Asn Ile Ile Cys Pro Gln
3170                3175                3180                3185

 aca aaa aga aag ttg aca tat aaa gaa gcc tta gaa aaa gct gat ttt     9897
 Thr Lys Arg Lys Leu Thr Tyr Lys Glu Ala Leu Glu Lys Ala Asp Phe
                3190                3195                3200

 gat ttc cac aca gga ctt aaa ctg tta gaa gta tct gag ccc ctg atg     9945
 Asp Phe His Thr Gly Leu Lys Leu Leu Glu Val Ser Glu Pro Leu Met
            3205                3210                3215

 aca gga att tct agc ctc tac tat tct tcc taa                         9978
 Thr Gly Ile Ser Ser Leu Tyr Tyr Ser Ser 
        3220                3225





      <210> 615
      <211> 1285
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (139)..(1026)

      <400> 615
 atgtagttcc ttgtcagaga gtgagagtac aaaaggaagt gctgatgcct tcctaagctc     60

 agttatcaaa attcttccag tatcgttcgc ctcactggta caagtaacaa cagtgctggt    120

 aaaatatcag gagaaagc  atg gaa agc aca cct gag ctg ctc tta ata tca     171
                      Met Glu Ser Thr Pro Glu Leu Leu Leu Ile Ser
                        1               5                  10

 tct ctt gaa gat aca aat gaa aca cga aac att caa agt aga tgc ttc      219
 Ser Leu Glu Asp Thr Asn Glu Thr Arg Asn Ile Gln Ser Arg Cys Phe
              15                  20                  25

 agg aaa aga cat aaa agt gac aat gaa act aat ttg cag cag caa gtg      267
 Arg Lys Arg His Lys Ser Asp Asn Glu Thr Asn Leu Gln Gln Gln Val
          30                  35                  40

 gtc tgg gga aat aga aac cgt aat ctt agt gga ggg gta ctg atg gga      315
 Val Trp Gly Asn Arg Asn Arg Asn Leu Ser Gly Gly Val Leu Met Gly
      45                  50                  55

 ttt atg ctc aat aga att aac cag gaa gca acc cct gga gat ata gtt      363
 Phe Met Leu Asn Arg Ile Asn Gln Glu Ala Thr Pro Gly Asp Ile Val
  60                  65                  70                  75

 gaa aaa ttg gga gct gat gca aaa att ctt tca aat gtt atc tca aaa      411
 Glu Lys Leu Gly Ala Asp Ala Lys Ile Leu Ser Asn Val Ile Ser Lys
                  80                  85                  90

 agc acg aga cca aat act ctt gat att ggg aag cca cct tta aga tca      459
 Ser Thr Arg Pro Asn Thr Leu Asp Ile Gly Lys Pro Pro Leu Arg Ser
              95                 100                 105

 aaa aga gac agt cta gaa aag gaa tct agt gat gat gat aca cct ttt      507
 Lys Arg Asp Ser Leu Glu Lys Glu Ser Ser Asp Asp Asp Thr Pro Phe
         110                 115                 120

 gat ggt tct aac tat ttg gca gat aaa gtg gat tct cct gtt att ttt      555
 Asp Gly Ser Asn Tyr Leu Ala Asp Lys Val Asp Ser Pro Val Ile Phe
     125                 130                 135

 gac tta gaa gac tta gac agt gaa aca gat gta tca aaa gca gga tgt      603
 Asp Leu Glu Asp Leu Asp Ser Glu Thr Asp Val Ser Lys Ala Gly Cys
 140                 145                 150                 155

 gtt gct aca caa aat ccc aag agg att caa cgt atg aac agc agc ttt      651
 Val Ala Thr Gln Asn Pro Lys Arg Ile Gln Arg Met Asn Ser Ser Phe
                 160                 165                 170

 tca gta aaa cct ttt gaa aaa act gat gtc gca aca gga ttt gat ccc      699
 Ser Val Lys Pro Phe Glu Lys Thr Asp Val Ala Thr Gly Phe Asp Pro
             175                 180                 185

 ctc tct ctt ttg gtt gct gag act gaa cag cag caa aaa gaa gaa gag      747
 Leu Ser Leu Leu Val Ala Glu Thr Glu Gln Gln Gln Lys Glu Glu Glu
         190                 195                 200

 gag gag gat gaa gat gat agc aaa agc att tca aca cca tct gct agg      795
 Glu Glu Asp Glu Asp Asp Ser Lys Ser Ile Ser Thr Pro Ser Ala Arg
     205                 210                 215

 cgt gat tta gct gaa gaa att gtg atg tat atg aat aac atg agc agt      843
 Arg Asp Leu Ala Glu Glu Ile Val Met Tyr Met Asn Asn Met Ser Ser
 220                 225                 230                 235

 cct ttg aca agt cgt aca cca agc att gat tta caa cgg gca tgt gat      891
 Pro Leu Thr Ser Arg Thr Pro Ser Ile Asp Leu Gln Arg Ala Cys Asp
                 240                 245                 250

 gat aaa tta aat aag aaa agt cca cca ttg gtc aag gca tgc aga aga      939
 Asp Lys Leu Asn Lys Lys Ser Pro Pro Leu Val Lys Ala Cys Arg Arg
             255                 260                 265

 tct agt ctg cct cct aat tct cct aag cca gtg aga ctt acc aaa tct      987
 Ser Ser Leu Pro Pro Asn Ser Pro Lys Pro Val Arg Leu Thr Lys Ser
         270                 275                 280

 aaa agt tac aca aaa agt gag gag aaa cca agg gat tag actttggtct      1036
 Lys Ser Tyr Thr Lys Ser Glu Glu Lys Pro Arg Asp 
     285                 290                 295

 tctccagcct tctcacctac ttgcccatta aacggagaca cgaacacctc aagagaataa   1096

 attaaacccc caacgagtaa ccgctaaagc gaaagcagaa ggaataccaa acgtagcgaa   1156

 cccacaagaa acaagtgcgc aaagagaacg ggaaagtccg acgacggaca cacaggagcc   1216

 gcgaaagaaa aacagcaaca agggatagac aagacaacca gagaaacaac aagtacacaa   1276

 aagagacgg                                                           1285




      <210> 616
      <211> 2135
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (150)..(527)

      <400> 616
 gcatgtacag gctgggtggt taatcggccg aggggcggat ggagggcgcg agcgggcggc     60

 cgcggaggct gcacccggcg gggcgctgat gcggcgcctg gaccttcgct gcgcgacttc    120

 gggggcgtcg gccgagttgg gactccgcg  atg cag ctc ctg aag gcg ctc tgg     173
                                  Met Gln Leu Leu Lys Ala Leu Trp
                                    1               5

 gca ctg gca ggg gcc gcg ctc tgc tgc ttc ctc gtc cta gtg atc cac      221
 Ala Leu Ala Gly Ala Ala Leu Cys Cys Phe Leu Val Leu Val Ile His
      10                  15                  20

 gcg cag ttc ctc aaa gaa ggt cag ctg gcc gcc ggc acc tgt gag att      269
 Ala Gln Phe Leu Lys Glu Gly Gln Leu Ala Ala Gly Thr Cys Glu Ile
  25                  30                  35                  40

 gtg acc ttg gac cgg gac agc agc cag cct cgg agg acg atc gcc cgg      317
 Val Thr Leu Asp Arg Asp Ser Ser Gln Pro Arg Arg Thr Ile Ala Arg
                  45                  50                  55

 cag acc gcc cgc tgt gcg tgt aga aag ggg cag atc gcc ggc acc acg      365
 Gln Thr Ala Arg Cys Ala Cys Arg Lys Gly Gln Ile Ala Gly Thr Thr
              60                  65                  70

 aga gcc cgg ccc gcc tgt gtg gac gca aga atc atc aag acc aag cag      413
 Arg Ala Arg Pro Ala Cys Val Asp Ala Arg Ile Ile Lys Thr Lys Gln
          75                  80                  85

 tgg tgt gac atg ctt ccg tgt ctg gag ggg gaa ggc tgc gac ttg tta      461
 Trp Cys Asp Met Leu Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu Leu
      90                  95                 100

 atc aac cgg tca ggc tgg acg tgc acg cag ccc ggc ggg agg ata aag      509
 Ile Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg Ile Lys
 105                 110                 115                 120

 acc acc acg gtc tcc tga caaaca cagcccctga ggggccccgg gagtggcctt      563
 Thr Thr Thr Val Ser 
                 125

 ggctccctgg agagcccacg tctcagccac agttctccac tcgcctcgga cttcacccgt    623

 tctctgccgc ccgcccactc cgtttccctg tggtccgtga aggacggcct caggccttgg    683

 catcctgagc ttcggtctgt ccagccgacc cgaggaggcc ggactcagac acataggcgg    743

 ggggcggcac ctggcatcag caatacgcag tctgtgggag cccggccgcg cccagccccc    803

 gccgaccgtg gcgttggccc tgctgtcctc agaggaggag gaggaggagg cagctccggc    863

 agccacagaa ggctgcagcc cagcccgcct gagacacgac gcctgcccca ggggactgtc    923

 aggcacagaa gcggcctcct cccgtgcccc agactgtccg aattgctttt attttcttat    983

 actttcagta tactccatag accaaagagc aaaatctatc tgaacctgga cgcaccctca   1043

 ctgtcagggt ccctggggtc gcttgtgcgg gcgggagggc aatggtggca gagacatgct   1103

 ggtggccccg gcggagcgga gagggcggcc gtggtggagg cctccacccc aggagcaccc   1163

 cgcacaccct cggaggacgg gcttcggctg cgcggaggcc gtggcacacc tgcgggaggc   1223

 agcgacggcc cccacgcaga cgccgggaac gcaggccgct ttattcctct gtacttagat   1283

 caacttgacc gtactaaaat ccctttctgt tttaaccagt taaacatgcc tcttctacag   1343

 ctccattttt gatagttgga taatccagta tctgccaaga gcatgttggg tctcccgtga   1403

 ctgctgcctc atcgataccc catttagctc cagaaagcaa agaaaactcg agtaacactt   1463

 gtttgaaaga gatcattaaa tgtattttgc aaagcctaaa gttatatatt taacagtttt   1523

 tatatgttgt atatttgtag aaaatcctat ttaacaatta acgtggcagt cccggccgtc   1583

 ctgagagtcg ggccgagccc cgtgtgtttc tgaagactct gggggtggga cacggcgggg   1643

 aggtggtgcc ccgcggaccc cggggtgcca ggcacggaag gcgggactct gggagaagcg   1703

 tgcggaggac cgtggcgtcg gcgtcccgga tgtgtcggtc gtgcccgggg aggccgggtt   1763

 cccctcgctg cgggccaggc ttggctcctg attccctctc tggtccctgt attggtcaac   1823

 acttgagcgt acaatatctt gaacatgctt cttccaatgg gttttgtttc ccatttcctg   1883

 cccctttcgc cactcacgga ccttgaggcc agttgacggc ccttctcccc acgcctgttt   1943

 cttttgaaag caagtgtaga caccttcgag ggcagagatc gggagattta agatgttaca   2003

 gcatattttt ttttcttgtt ttacagtatt caattttgtg ttgattcagc taaattatga   2063

 aaaataaaga aaaactcctt tgataaaaaa aaaaaaaaaa aaaaaaatat gcggccgcaa   2123

 gcttgtgcct tt                                                       2135




      <210> 617
      <211> 1310
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (407)..(850)

      <400> 617
 tggaaggcca ttccccgtct tgccggactt cgtgccactg cctcccatct gctccaactc     60

 cactgtgcat agtgaagaga ccctgtccca cctgagtgac acaactgtcc gcctcagccc    120

 agagcgccca tcagatgagg actccaagag cacagagtcc atcttcctga cccaggtgag    180

 tgaactgcct tcctccgtca tccataagga tgatttagag ttaaaggaga aagaccaaaa    240

 gaaaccacca acggcaccca gagaggtgaa agggactcgg aggaaactcc caactgcctt    300

 ccttcccagc aagtaccacg gctatgaaga actgctgaca gccaagcctg atccagcctt    360

 cattgagcca aagggaatcc agaagaatgc acaagccctg caacaa   atg ctg aag     415
                                                      Met Leu Lys
                                                        1

 cac cca ctc ctg tgc cac tcc tcc aag ccc aag ctg gac act ctt cag      463
 His Pro Leu Leu Cys His Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln
       5                  10                  15

 aaa ccc tat gtt cac aaa gag aaa cgg gcc cag aga atc ccg att cca      511
 Lys Pro Tyr Val His Lys Glu Lys Arg Ala Gln Arg Ile Pro Ile Pro
  20                  25                  30                  35

 ccc cca aag aag act aga gcc caa ctt ctg gat gac atc ttc att cgc      559
 Pro Pro Lys Lys Thr Arg Ala Gln Leu Leu Asp Asp Ile Phe Ile Arg
                  40                  45                  50

 ttg cgg gat ccc cgg aac att aca gag gct cca cta ggt gct gtc ctg      607
 Leu Arg Asp Pro Arg Asn Ile Thr Glu Ala Pro Leu Gly Ala Val Leu
              55                  60                  65

 cac cag tgg aca gaa cgg cgg ctg gtg aac cac aag cag tac ctg gag      655
 His Gln Trp Thr Glu Arg Arg Leu Val Asn His Lys Gln Tyr Leu Glu
          70                  75                  80

 gcc aag agg ctg ttg aag gag ttc cag gca cgt tac cgg cag ctg gtg      703
 Ala Lys Arg Leu Leu Lys Glu Phe Gln Ala Arg Tyr Arg Gln Leu Val
      85                  90                  95

 agt ggc tct ctg cgc aca gtg ttc ggg act acc ccg ctc ccc atg gcc      751
 Ser Gly Ser Leu Arg Thr Val Phe Gly Thr Thr Pro Leu Pro Met Ala
 100                 105                 110                 115

 tgc cca gcg ctg agt gag agc cag ccc aag ttc ggc cac ttc ctc gag      799
 Cys Pro Ala Leu Ser Glu Ser Gln Pro Lys Phe Gly His Phe Leu Glu
                 120                 125                 130

 ttc atg gat gag ttc tgc cag gag ccc aca gcc agt gac tca caa ggc      847
 Phe Met Asp Glu Phe Cys Gln Glu Pro Thr Ala Ser Asp Ser Gln Gly
             135                 140                 145

 tag agct gtgcatgggg gctgtgtgca ccacccggcc tgtgccccag ctctccccga      904
 


 gggctctgtg ccctggaccg cacctcaagg ttgaccagcc ggccacaggc ctcagagctc    964

 agctgggccc cacttgctgg ccacaaggtg gcatcccctt gtcaggatct cccctccttg   1024

 gcccaggcat gacctggtgc ctggcccagc ggcaataaag agtgggtgca cagggcaata   1084

 gactgggtgc cacatgcatt ctttcttgga acccaggcca cagcagcatc ggcacactta   1144

 ccctctaaca aatgggttta ccagttcaga tgcaacaggg atacataaag tactctggtc   1204

 ggtatgagaa aactggacac ccaaggggca tctaaaccca aaattcctgg accccatggg   1264

 gatccaagca aacgggcata ctgagtccaa aaggcaagaa tcttgg                  1310




      <210> 618
      <211> 348
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(348)

      <400> 618
 ttttttataa tgccaacttt gtacaaaaaa gcaggctccg cggccgcccc cttcacc        57                                                                 
 atg agc ttg gtg cct ctc ctg gct tct ttt cct gca ggt gct gtc ctg      105
 Met Ser Leu Val Pro Leu Leu Ala Ser Phe Pro Ala Gly Ala Val Leu
   1               5                  10                  15

 cac cag tgg aca gaa cgg cgg ctg gtg aac aac aag cag tac ctg gag      153
 His Gln Trp Thr Glu Arg Arg Leu Val Asn Asn Lys Gln Tyr Leu Glu
              20                  25                  30

 gcc aag agg ctg ttg aag gag ttc cag gca cgt tac cgg cag ctg gtg      201
 Ala Lys Arg Leu Leu Lys Glu Phe Gln Ala Arg Tyr Arg Gln Leu Val
          35                  40                  45

 agt ggc tct ctg cgc aca gtg ttc ggg act acc ccg ctc ccc atg gcc      249
 Ser Gly Ser Leu Arg Thr Val Phe Gly Thr Thr Pro Leu Pro Met Ala
      50                  55                  60

 tgc cca gcg ctg agt gag agc cag ccc aag ttc ggc cac ttc ctc gag      297
 Cys Pro Ala Leu Ser Glu Ser Gln Pro Lys Phe Gly His Phe Leu Glu
  65                  70                  75                  80

 ttc atg gat gag ttc tgc cag gag ccc aca gcc agt gac tca caa ggc      345
 Phe Met Asp Glu Phe Cys Gln Glu Pro Thr Ala Ser Asp Ser Gln Gly
                  85                  90                  95

 tag                                                                  348
 






      <210> 619
      <211> 361
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(296)

      <400> 619
 gcttttttat aatgccaact ttgtacaaaa aagcaggctc cgcggccgcc cccttcacc      59                                                                 
 atg ctg tcc tgc cgc ctc cag tgc gcg ctg gct gcg ctg tcc atc gtc      107
 Met Leu Ser Cys Arg Leu Gln Cys Ala Leu Ala Ala Leu Ser Ile Val
   1               5                  10                  15

 ctg gcc ctg ggc tgt gtc acc ggc gct ccc tcg gac ccc aga ctc cgt      155
 Leu Ala Leu Gly Cys Val Thr Gly Ala Pro Ser Asp Pro Arg Leu Arg
              20                  25                  30

 cag ttt ctg cag aag tcc ctg gct gct gcc gcg ggg aag cag gta agg      203
 Gln Phe Leu Gln Lys Ser Leu Ala Ala Ala Ala Gly Lys Gln Val Arg
          35                  40                  45

 aga ctc cct cga cgt ctc ccg gat tct cca gcc ctc cct aag cct tgc      251
 Arg Leu Pro Arg Arg Leu Pro Asp Ser Pro Ala Leu Pro Lys Pro Cys
      50                  55                  60

 tcc tgc ccc att ggt ttg gac gta agg gat gct cag tcc ttc taa aga      299
 Ser Cys Pro Ile Gly Leu Asp Val Arg Asp Ala Gln Ser Phe 
  65                  70                  75

 gttttggtgc ttttctgggt ccctcagctc ccgaagctct tgagaaaact atcaaaggct    359

 ag                                                                   361




      <210> 620
      <211> 4609
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (166)..(1686)

      <400> 620
 gcggtagcgc gcgcccgcgc gcgttcttag tactctcccc ggtgacgtgc ctgaccgagg     60

 ccgcgccagg cgctgttgct gccaatacag ctgtcatggc gtccaaggcg ctggctgcgg    120

 agaagtggcc gcggtctcca tagagctggg ggcgggcggc ccggt    atg gag agc     174
                                                      Met Glu Ser
                                                        1

 agc ccc gag agc ctg cag ccg cta gaa cac ggg gtg gcg gcc ggg cca      222
 Ser Pro Glu Ser Leu Gln Pro Leu Glu His Gly Val Ala Ala Gly Pro
       5                  10                  15

 gcg tca ggg aca ggt tct tcg cag gaa ggg cta cag gag acc agg ctc      270
 Ala Ser Gly Thr Gly Ser Ser Gln Glu Gly Leu Gln Glu Thr Arg Leu
  20                  25                  30                  35

 gcc gct ggt gat ggt cct ggg gta tgg gcg gcg gag acc agc ggc ggg      318
 Ala Ala Gly Asp Gly Pro Gly Val Trp Ala Ala Glu Thr Ser Gly Gly
                  40                  45                  50

 aat ggg ctg ggg gcg gcg gcc gcc agg agg agc ctc ccg gac tcg gct      366
 Asn Gly Leu Gly Ala Ala Ala Ala Arg Arg Ser Leu Pro Asp Ser Ala
              55                  60                  65

 tct ccc gcg ggc tct cct gag gtt ccc gga ccc tgc agc tcc tcc gcg      414
 Ser Pro Ala Gly Ser Pro Glu Val Pro Gly Pro Cys Ser Ser Ser Ala
          70                  75                  80

 ggt ttg ggc ttg aag gac agt ggt ttg gag agt cct gct gcc gcc gag      462
 Gly Leu Gly Leu Lys Asp Ser Gly Leu Glu Ser Pro Ala Ala Ala Glu
      85                  90                  95

 gcg cct ctg tgc aag gag gag gag ggg gag gag acc gct cag gtg ctg      510
 Ala Pro Leu Cys Lys Glu Glu Glu Gly Glu Glu Thr Ala Gln Val Leu
 100                 105                 110                 115

 gcg gcc tcc aag gaa cgc ttc ccg gga caa tct gtg tat cac atc aag      558
 Ala Ala Ser Lys Glu Arg Phe Pro Gly Gln Ser Val Tyr His Ile Lys
                 120                 125                 130

 tgg atc cag tgg aag gaa gag aac aca ccc atc atc acc cag aat gag      606
 Trp Ile Gln Trp Lys Glu Glu Asn Thr Pro Ile Ile Thr Gln Asn Glu
             135                 140                 145

 aac gga ccc tgc ccc ttg ctg gcc atc ctc aat gtt ttg ctc ctg gcc      654
 Asn Gly Pro Cys Pro Leu Leu Ala Ile Leu Asn Val Leu Leu Leu Ala
         150                 155                 160

 tgg aag gtg aaa ctt cca ccg atg atg gaa atc ata act gct gag cag      702
 Trp Lys Val Lys Leu Pro Pro Met Met Glu Ile Ile Thr Ala Glu Gln
     165                 170                 175

 ctg atg gaa tat tta gga gat tac atg ctt gat gca aag cca aaa gaa      750
 Leu Met Glu Tyr Leu Gly Asp Tyr Met Leu Asp Ala Lys Pro Lys Glu
 180                 185                 190                 195

 att tca gaa att caa cgt tta aat tat gaa cag aat atg agt gat gcc      798
 Ile Ser Glu Ile Gln Arg Leu Asn Tyr Glu Gln Asn Met Ser Asp Ala
                 200                 205                 210

 atg gca att ttg cac aaa cta cag aca ggc ctg gat gta aat gta aga      846
 Met Ala Ile Leu His Lys Leu Gln Thr Gly Leu Asp Val Asn Val Arg
             215                 220                 225

 ttc act ggt gtt cga gtg ttt gaa tat aca cca gaa tgc ata gta ttt      894
 Phe Thr Gly Val Arg Val Phe Glu Tyr Thr Pro Glu Cys Ile Val Phe
         230                 235                 240

 gat ctt ctt gat att cct ttg tac cat ggg tgg tta gta gac cct cag      942
 Asp Leu Leu Asp Ile Pro Leu Tyr His Gly Trp Leu Val Asp Pro Gln
     245                 250                 255

 att gat gac att gta aaa gct gtt ggt aac tgc agc tac aac caa cta      990
 Ile Asp Asp Ile Val Lys Ala Val Gly Asn Cys Ser Tyr Asn Gln Leu
 260                 265                 270                 275

 gtg gag aag atc atc tct tgt aaa cag tca gac aat agt gag ctg gtt     1038
 Val Glu Lys Ile Ile Ser Cys Lys Gln Ser Asp Asn Ser Glu Leu Val
                 280                 285                 290

 agt gaa ggc ttt gta gct gag cag ttt cta aat aac aca gcc act caa     1086
 Ser Glu Gly Phe Val Ala Glu Gln Phe Leu Asn Asn Thr Ala Thr Gln
             295                 300                 305

 ctg aca tac cat gga tta tgt gaa cta act tca acg gtt cag gaa gga     1134
 Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ser Thr Val Gln Glu Gly
         310                 315                 320

 gaa ctt tgt gtg ttc ttt cgg aat aat cat ttt agc acc atg acc aaa     1182
 Glu Leu Cys Val Phe Phe Arg Asn Asn His Phe Ser Thr Met Thr Lys
     325                 330                 335

 tac aag ggt caa ctg tat ttg ttg gta acg gac cag ggg ttt ctt act     1230
 Tyr Lys Gly Gln Leu Tyr Leu Leu Val Thr Asp Gln Gly Phe Leu Thr
 340                 345                 350                 355

 gaa gag aaa gtt gtt tgg gaa agc cta cac aac gta gat ggt gat gga     1278
 Glu Glu Lys Val Val Trp Glu Ser Leu His Asn Val Asp Gly Asp Gly
                 360                 365                 370

 aat ttc tgt gac tca gaa ttt cat ctt cga cct cct tca gat cct gaa     1326
 Asn Phe Cys Asp Ser Glu Phe His Leu Arg Pro Pro Ser Asp Pro Glu
             375                 380                 385

 act gta tac aaa gga caa caa gat cag ata gat cag gat tat ctt atg     1374
 Thr Val Tyr Lys Gly Gln Gln Asp Gln Ile Asp Gln Asp Tyr Leu Met
         390                 395                 400

 gca tta tct cta caa caa gaa cag cag agc caa gag atc aat tgg gaa     1422
 Ala Leu Ser Leu Gln Gln Glu Gln Gln Ser Gln Glu Ile Asn Trp Glu
     405                 410                 415

 caa atc ccg gaa gga atc agt gat ttg gaa cta gca aag aaa ctc caa     1470
 Gln Ile Pro Glu Gly Ile Ser Asp Leu Glu Leu Ala Lys Lys Leu Gln
 420                 425                 430                 435

 gag gaa gag gac aga cgg gct tct caa tac tat cag gaa cag gaa caa     1518
 Glu Glu Glu Asp Arg Arg Ala Ser Gln Tyr Tyr Gln Glu Gln Glu Gln
                 440                 445                 450

 gca gca gct gct gct gct gct gct tct aca cag gct cag cag ggc cag     1566
 Ala Ala Ala Ala Ala Ala Ala Ala Ser Thr Gln Ala Gln Gln Gly Gln
             455                 460                 465

 cca gca caa gcc tct cca tca agt gga aga caa tct ggg aat agt gaa     1614
 Pro Ala Gln Ala Ser Pro Ser Ser Gly Arg Gln Ser Gly Asn Ser Glu
         470                 475                 480

 cgt aaa cgg aag gaa cca cga gaa aaa gat aaa gaa aaa gaa aaa gaa     1662
 Arg Lys Arg Lys Glu Pro Arg Glu Lys Asp Lys Glu Lys Glu Lys Glu
     485                 490                 495

 aaa aat agc tgt gtt att ttg taa caagtgttgg cttctgttgg aaccacctat    1716
 Lys Asn Ser Cys Val Ile Leu 
 500                 505

 atgtcttgag aaacaaaacc acaggaggaa aggaagaaaa accgatcaat accgtctgtg   1776

 cctgatttcc taatggattt tgttcgtttt ttcaggggaa cggttgttac ttagttacaa   1836

 tcagactttt tcaagtcaca caatacactc tttatgagct ggagtttcat gttacaagtt   1896

 ggaaatgctg tgtgttgtca ttcatgaaaa atactgcact tgtagccaga ttagcaaatc   1956

 acagcaaatt ttgtgtcata gtgacattca taactcatat cagttagtaa gctattatat   2016

 cttctgttct aacaatgaat ggaggtaatt gatttagtct gattccttcc tgaaatctaa   2076

 atattagcac aatagtttct gaaattttac aatgttaaat tatgatctaa ttcatgagaa   2136

 accacgggtt taacataggg attcaaaaaa acaaaaacaa aagaatagga ataaataacc   2196

 cttaattgta tattggacta gttcagccct taaacagctt tacctttatt taggaatgta   2256

 cattttaggt attatcttga tcatggagct tagatttaat ttagatagca aaaataaaga   2316

 tttgtatttc ttttccaata gcaaaaagtt acataacact aatacttata acctatcaat   2376

 atcagatatt aatgactttg tagtgttgta aaattttgag gaattttgga gtctttatca   2436

 taggtaacct ggaccacagt tactatttat tgacaatgtg attgagtgta tggaggaaag   2496

 cacagtggat gctaggcttt gtaaatatgg ggatgtagaa aagcagatag ttcagtgtct   2556

 acctttttct agaactacct tgaaccttaa attttaagtc atgttcattg ctagaaaatt   2616

 aaatgtactt attaaaacca atgaaaaagc acatttctga aatgaagtta gagataatct   2676

 ctgtgtctta taaaaagaca ttaataaaaa tctgaaaggg ccgggcgcag tggctcacgc   2736

 ctgtaatccc aacattttgg gaggccaagg tgggcggatc atctgaggcc aggagttcga   2796

 gaccagcctg gccagcatgg tgaaaccctg tctctactaa aaatacaaaa aatcagcctg   2856

 gcatggtggt gcgtgcctgt agtcccagct actcagggct gaggcaggag aattgcttga   2916

 acccggcagg cagaggttgc agtgagccga gatcgccctg ctgcactcca gcctgggtga   2976

 cagagggaga ctccgtctca aaaaaaaaaa agtctgagag tagctaagaa tttatgtaaa   3036

 agcaatcaga gtttttaatt tatgggaacc aaataaaact ataacctcat agtgtttata   3096

 agaactcaga aataatattt atttaacttt attatgaggc cacacatatt ttcctgtgtt   3156

 tctatatata gtttggaaaa ctatccttaa tagtctgttt tatatgcctt atatttaaaa   3216

 gtttgtttta gttattttga aagactattg ctgctgcaaa tagttgtgtg ctttacattc   3276

 taagcttcag tacatttatt taagagcatc ataatctgac ctgagcatcc acttggagag   3336

 tgtttttttt gtgtgtggtc tggggtgaca aaagaccaca aaaatgtgtg gtctggattt   3396

 tttcaactat gtcattaact ttatgatcca agaccagtta taggatgaat ctgtatgtaa   3456

 aaatagagtc ttatttatgg aaggaattat tctaagggaa aaatccaggg tcaagctgta   3516

 tcttttatgt cctttatatt gcatgtctat ttctgttaca caatttgtta tttcttcaaa   3576

 tttcctatgg tagcatgata aatcatcaaa gaacctgttt gggatataaa actctgatag   3636

 aaaatattta atgagtatct tgattataac ctagaatatg tatacgttag taaaataacc   3696

 agatatacta cagaactctc tattggctca aacaggttga cctcaatcca agtttactct   3756

 tgatatcact ctgttggctg aaggaggtaa ctcaaacctc agggtttgtt tttcccggga   3816

 cagatagtag tgatagtgca ttatatttga ataagaaaaa caaaccagta taccttgaga   3876

 aattttaaaa agcatagttg aggcatattt tttcataatt atatacttat ctgtttattg   3936

 cccatggaaa atatatgtgt agaagtattt cttctgttat ttgttactat cttcttaatt   3996

 tgttccaaag aaaatgctgc catactgcat tccctctgga aggaaacaaa acaaaacaaa   4056

 actcactcaa aaccagcagt gctgctatca gataagtaga tgtcaatgta tacttacaag   4116

 gaaaaactaa aaaatgtaat gtgttaattc agcctttttc tatgtaatat ttccaagtca   4176

 gactttctta cattcctgga atttactttg atataccaag aataataatg ataaaatgtt   4236

 tgctttgatt actgtggggg gaaagatgaa atgttcaatt atattaaaac aaacaagctt   4296

 ttcagagata ctggtttcct gcccttgaag ggtataaaga atttagatca tgcctgtaat   4356

 cccagtactt tgggaggccg aggcaggtgg atcacctgag atcaggagtt cgagaccagc   4416

 ctggccaaca tggcaaaacc ctgtctctac taaaaataca ataattagcc aggcatggtg   4476

 gcgggcacct gtcatcccag ctacttggga ggctgaggca ggagaatcgc ttgaacccag   4536

 gaggcagtga ttgcagtgag ctgagatagc accactgcat gcaagcctgg gcaatagagc   4596

 gagactccgt ctc                                                      4609




      <210> 621
      <211> 4954
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (166)..(2031)

      <400> 621
 gcggtagcgc gcgcccgcgc gcgttcttag tactctcccc ggtgacgtgc ctgaccgagg     60

 ccgcgccagg cgctgttgct gccaatacag ctgtcatggc gtccaaggcg ctggctgcgg    120

 agaagtggcc gcggtctcca tagagctggg ggcgggcggc ccggt    atg gag agc     174
                                                      Met Glu Ser
                                                        1

 agc ccc gag agc ctg cag ccg cta gaa cac ggg gtg gcg gcc ggg cca      222
 Ser Pro Glu Ser Leu Gln Pro Leu Glu His Gly Val Ala Ala Gly Pro
       5                  10                  15

 gcg tca ggg aca ggt tct tcg cag gaa ggg cta cag gag acc agg ctc      270
 Ala Ser Gly Thr Gly Ser Ser Gln Glu Gly Leu Gln Glu Thr Arg Leu
  20                  25                  30                  35

 gcc gct ggt gat ggt cct ggg gta tgg gcg gcg gag acc agc ggc ggg      318
 Ala Ala Gly Asp Gly Pro Gly Val Trp Ala Ala Glu Thr Ser Gly Gly
                  40                  45                  50

 aat ggg ctg ggg gcg gcg gcc gcc agg agg agc ctc ccg gac tcg gct      366
 Asn Gly Leu Gly Ala Ala Ala Ala Arg Arg Ser Leu Pro Asp Ser Ala
              55                  60                  65

 tct ccc gcg ggc tct cct gag gtt ccc gga ccc tgc agc tcc tcc gcg      414
 Ser Pro Ala Gly Ser Pro Glu Val Pro Gly Pro Cys Ser Ser Ser Ala
          70                  75                  80

 ggt ttg gac ttg aag gac agt ggt ttg gag agt cct gct gcc gcc gag      462
 Gly Leu Asp Leu Lys Asp Ser Gly Leu Glu Ser Pro Ala Ala Ala Glu
      85                  90                  95

 gcg cct ctg aga ggg cag tac aag gtg acc gcc tcc ccg gag aca gcc      510
 Ala Pro Leu Arg Gly Gln Tyr Lys Val Thr Ala Ser Pro Glu Thr Ala
 100                 105                 110                 115

 gtg gcc gga gtg ggt cat gag ttg ggt acc gcc gga gac gcg gga gcc      558
 Val Ala Gly Val Gly His Glu Leu Gly Thr Ala Gly Asp Ala Gly Ala
                 120                 125                 130

 cgc ccg gat ctc gcc ggc acc tgc caa gca gaa ctg acc gcc gcc ggc      606
 Arg Pro Asp Leu Ala Gly Thr Cys Gln Ala Glu Leu Thr Ala Ala Gly
             135                 140                 145

 tcc gaa gag ccc agc agc gcc ggc ggc ctc agc agc agt tgc agc gac      654
 Ser Glu Glu Pro Ser Ser Ala Gly Gly Leu Ser Ser Ser Cys Ser Asp
         150                 155                 160

 ccg agc cct cct ggg gaa tct ccg agc ctg gac tct ctg gag tcg ttc      702
 Pro Ser Pro Pro Gly Glu Ser Pro Ser Leu Asp Ser Leu Glu Ser Phe
     165                 170                 175

 tct aac ctg cat tct ttt ccc agt agc tgc gag ttc aat agt gag gag      750
 Ser Asn Leu His Ser Phe Pro Ser Ser Cys Glu Phe Asn Ser Glu Glu
 180                 185                 190                 195

 gga gcg gag aac agg gtc cct gag gag gag gag ggc gcg gcg gtg ttg      798
 Gly Ala Glu Asn Arg Val Pro Glu Glu Glu Glu Gly Ala Ala Val Leu
                 200                 205                 210

 ccc ggg gct gtt cct ctg tgc aag gag gag gag ggg gag gag acc gct      846
 Pro Gly Ala Val Pro Leu Cys Lys Glu Glu Glu Gly Glu Glu Thr Ala
             215                 220                 225

 cag gtg ctg gcg gcc tcc aag gaa cgc ttc ccg gga caa tct gtg tat      894
 Gln Val Leu Ala Ala Ser Lys Glu Arg Phe Pro Gly Gln Ser Val Tyr
         230                 235                 240

 cac atc aag tgg atc cag tgg aag gaa gag aac aca ccc atc atc acc      942
 His Ile Lys Trp Ile Gln Trp Lys Glu Glu Asn Thr Pro Ile Ile Thr
     245                 250                 255

 cag aat gag aac gga ccc tgc ccc ttg ctg gcc atc ctc aat gtt ttg      990
 Gln Asn Glu Asn Gly Pro Cys Pro Leu Leu Ala Ile Leu Asn Val Leu
 260                 265                 270                 275

 ctc ctg gcc tgg aag gtg aaa ctt cca ccg atg atg gaa atc ata act     1038
 Leu Leu Ala Trp Lys Val Lys Leu Pro Pro Met Met Glu Ile Ile Thr
                 280                 285                 290

 gct gag cag ctg atg gaa tat tta gga gat tac atg ctt gat gca aag     1086
 Ala Glu Gln Leu Met Glu Tyr Leu Gly Asp Tyr Met Leu Asp Ala Lys
             295                 300                 305

 cca aaa gaa att tca gaa att caa cgt tta aat tat gaa cag aat atg     1134
 Pro Lys Glu Ile Ser Glu Ile Gln Arg Leu Asn Tyr Glu Gln Asn Met
         310                 315                 320

 agt gat gcc atg gca att ttg cac aaa cta cag aca ggc ctg gat gta     1182
 Ser Asp Ala Met Ala Ile Leu His Lys Leu Gln Thr Gly Leu Asp Val
     325                 330                 335

 aat gta aga ttc act ggt gtt cga gtg ttt gaa tat aca cca gaa tgc     1230
 Asn Val Arg Phe Thr Gly Val Arg Val Phe Glu Tyr Thr Pro Glu Cys
 340                 345                 350                 355

 ata gta ttt gat ctt ctt gat att cct ttg tac cat ggg tgg tta gta     1278
 Ile Val Phe Asp Leu Leu Asp Ile Pro Leu Tyr His Gly Trp Leu Val
                 360                 365                 370

 gac cct cag att gat gac att gta aaa gct gtt ggt aac tgc agc tac     1326
 Asp Pro Gln Ile Asp Asp Ile Val Lys Ala Val Gly Asn Cys Ser Tyr
             375                 380                 385

 aac caa cta gtg gag aag atc atc tct tgt aaa cag tca gac aat agt     1374
 Asn Gln Leu Val Glu Lys Ile Ile Ser Cys Lys Gln Ser Asp Asn Ser
         390                 395                 400

 gag ctg gtt agt gaa ggc ttt gta gct gag cag ttt cta aat aac aca     1422
 Glu Leu Val Ser Glu Gly Phe Val Ala Glu Gln Phe Leu Asn Asn Thr
     405                 410                 415

 gcc act caa ctg aca tac cat gga tta tgt gaa cta act tca acg gtt     1470
 Ala Thr Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ser Thr Val
 420                 425                 430                 435

 cag gaa gga gaa ctt tgt gtg ttc ttt cgg aat aat cat ttt agc acc     1518
 Gln Glu Gly Glu Leu Cys Val Phe Phe Arg Asn Asn His Phe Ser Thr
                 440                 445                 450

 atg acc aaa tac aag ggt caa ctg tat ttg ttg gta acg gac cag ggg     1566
 Met Thr Lys Tyr Lys Gly Gln Leu Tyr Leu Leu Val Thr Asp Gln Gly
             455                 460                 465

 ttt ctt act gaa gag aaa gtt gtt tgg gaa agc cta cac aac gta gat     1614
 Phe Leu Thr Glu Glu Lys Val Val Trp Glu Ser Leu His Asn Val Asp
         470                 475                 480

 ggt gat gga aat ttc tgt gac tca gaa ttt cat ctt cga cct cct tca     1662
 Gly Asp Gly Asn Phe Cys Asp Ser Glu Phe His Leu Arg Pro Pro Ser
     485                 490                 495

 gat cct gaa act gta tac aaa gga caa caa gat cag ata gat cag gat     1710
 Asp Pro Glu Thr Val Tyr Lys Gly Gln Gln Asp Gln Ile Asp Gln Asp
 500                 505                 510                 515

 tat ctt atg gca tta tct cta caa caa gaa cag cag agc caa gag atc     1758
 Tyr Leu Met Ala Leu Ser Leu Gln Gln Glu Gln Gln Ser Gln Glu Ile
                 520                 525                 530

 aat tgg gaa caa atc ccg gaa gga atc agt gat ttg gaa cta gca aag     1806
 Asn Trp Glu Gln Ile Pro Glu Gly Ile Ser Asp Leu Glu Leu Ala Lys
             535                 540                 545

 aaa ctc caa gag gaa gag gac aga cgg gct tct caa tac tat cag gaa     1854
 Lys Leu Gln Glu Glu Glu Asp Arg Arg Ala Ser Gln Tyr Tyr Gln Glu
         550                 555                 560

 cag gaa caa gca gca gct gct gct gct gct gct tct aca cag gct cag     1902
 Gln Glu Gln Ala Ala Ala Ala Ala Ala Ala Ala Ser Thr Gln Ala Gln
     565                 570                 575

 cag ggc cag cca gca caa gcc tct cca tca agt gga aga caa tct ggg     1950
 Gln Gly Gln Pro Ala Gln Ala Ser Pro Ser Ser Gly Arg Gln Ser Gly
 580                 585                 590                 595

 aat agt gaa cgt aaa cgg aag gaa cca cga gaa aaa gat aaa gaa aaa     1998
 Asn Ser Glu Arg Lys Arg Lys Glu Pro Arg Glu Lys Asp Lys Glu Lys
                 600                 605                 610

 gaa aaa gaa aaa aat agc tgt gtt att ttg taa caagtgtt ggcttctgtt     2049
 Glu Lys Glu Lys Asn Ser Cys Val Ile Leu 
             615                 620

 ggaaccacct atatgtcttg agaaacaaaa ccacaggagg aaaggaagaa aaaccgatca   2109

 ataccgtctg tgcctgattt cctaatggat tttgttcgtt ttttcagggg aacggttgtt   2169

 acttagttac aatcagactt tttcaagtca cacaatacac tctttatgag ctggagtttc   2229

 atgttacaag ttggaaatgc tgtgtgttgt cattcatgaa aaatactgca cttgtagcca   2289

 gattagcaaa tcacagcaaa ttttgtgtca tagtgacatt cataactcat atcagttagt   2349

 aagctattat atcttctgtt ctaacaatga atggaggtaa ttgatttagt ctgattcctt   2409

 cctgaaatct aaatattagc acaatagttt ctgaaatttt acaatgttaa attatgatct   2469

 aattcatgag aaaccacggg tttaacatag ggattcaaaa aaacaaaaac aaaagaatag   2529

 gaataaataa cccttaattg tatattggac tagttcagcc cttaaacagc tttaccttta   2589

 tttaggaatg tacattttag gtattatctt gatcatggag cttagattta atttagatag   2649

 caaaaataaa gatttgtatt tcttttccaa tagcaaaaag ttacataaca ctaatactta   2709

 taacctatca atatcagata ttaatgactt tgtagtgttg taaaattttg aggaattttg   2769

 gagtctttat cataggtaac ctggaccaca gttactattt attgacaatg tgattgagtg   2829

 tatggaggaa agcacagtgg atgctaggct ttgtaaatat ggggatgtag aaaagcagat   2889

 agttcagtgt ctaccttttt ctagaactac cttgaacctt aaattttaag tcatgttcat   2949

 tgctagaaaa ttaaatgtac ttattaaaac caatgaaaaa gcacatttct gaaatgaagt   3009

 tagagataat ctctgtgtct tataaaaaga cattaataaa aatctgaaag ggccgggcgc   3069

 agtggctcac gcctgtaatc ccaacatttt gggaggccaa ggtgggcgga tcatctgagg   3129

 ccaggagttc gagaccagcc tggccagcat ggtgaaaccc tgtctctact aaaaatacaa   3189

 aaaatcagcc tggcatggtg gtgcgtgcct gtagtcccag ctactcaggg ctgaggcagg   3249

 agaattgctt gaacccggca ggcagaggtt gcagtgagcc gagatcgccc tgctgcactc   3309

 cagcctgggt gacagaggga gactccgtct caaaaaaaaa aaagtctgag agtagctaag   3369

 aatttatgta aaagcaatca gagtttttaa tttatgggaa ccaaataaaa ctataacctc   3429

 atagtgttta taagaactca gaaataatat ttatttaact ttattatgag gccacacata   3489

 ttttcctgtg tttctatata tagtttggaa aactatcctt aatagtctgt tttatatgcc   3549

 ttatatttaa aagtttgttt tagttatttt gaaagactat tgctgctgca aatagttgtg   3609

 tgctttacat tctaagcttc agtacattta tttaagagca tcataatctg acctgagcat   3669

 ccacttggag agtgtttttt ttgtgtgtgg tctggggtga caaaagacca caaaaatgtg   3729

 tggtctggat tttttcaact atgtcattaa ctttatgatc caagaccagt tataggatga   3789

 atctgtatgt aaaaatagag tcttatttat ggaaggaatt attctaaggg aaaaatccag   3849

 ggtcaagctg tatcttttat gtcctttata ttgcatgtct atttctgtta cacaatttgt   3909

 tatttcttca aatttcctat ggtagcatga taaatcatca aagaacctgt ttgggatata   3969

 aaactctgat agaaaatatt taatgagtat cttgattata acctagaata tgtatacgtt   4029

 agtaaaataa ccagatatac tacagaactc tctattggct caaacaggtt gacctcaatc   4089

 caagtttact cttgatatca ctctgttggc tgaaggaggt aactcaaacc tcagggtttg   4149

 tttttcccgg gacagatagt agtgatagtg cattatattt gaataagaaa aacaaaccag   4209

 tataccttga gaaattttaa aaagcatagt tgaggcatat tttttcataa ttatatactt   4269

 atctgtttat tgcccatgga aaatatatgt gtagaagtat ttcttctgtt atttgttact   4329

 atcttcttaa tttgttccaa agaaaatgct gccatactgc attccctctg gaaggaaaca   4389

 aaacaaaaca aaactcactc aaaaccagca gtgctgctat cagataagta gatgtcaatg   4449

 tatacttaca aggaaaaact aaaaaatgta atgtgttaat tcagcctttt tctatgtaat   4509

 atttccaagt cagactttct tacattcctg gaatttactt tgatatacca agaataataa   4569

 tgataaaatg tttgctttga ttactgtggg gggaaagatg aaatgttcaa ttatattaaa   4629

 acaaacaagc ttttcagaga tactggtttc ctgcccttga agggtataaa gaatttagat   4689

 catgcctgta atcccagtac tttgggaggc cgaggcaggt ggatcacctg agatcaggag   4749

 ttcgagacca gcctggccaa catggcaaaa ccctgtctct actaaaaata caataattag   4809

 ccaggcatgg tggcgggcac ctgtcatccc agctacttgg gaggctgagg caggagaatc   4869

 gcttgaaccc aggaggcagt gattgcagtg agctgagata gcaccactgc atgcaagcct   4929

 gggcaataga gcgagactcc gtctc                                         4954




      <210> 622
      <211> 2192
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1893)

      <400> 622
  atg tgg aaa gga agt agt tcc atg tta atc tat gtg aga tca gat cct      48
  Met Trp Lys Gly Ser Ser Ser Met Leu Ile Tyr Val Arg Ser Asp Pro
    1               5                  10                  15

 tat cac aaa gat gac aac atc cag att ggc cgt gag gtg aaa ata tct       96
 Tyr His Lys Asp Asp Asn Ile Gln Ile Gly Arg Glu Val Lys Ile Ser
              20                  25                  30

 tgc caa gta gaa gct gtt cct tct gag gag cta aca ttt agt tgg ttt      144
 Cys Gln Val Glu Ala Val Pro Ser Glu Glu Leu Thr Phe Ser Trp Phe
          35                  40                  45

 aaa aat ggt cgt cca tta aga agt tct gag cgg atg gtc att aca cag      192
 Lys Asn Gly Arg Pro Leu Arg Ser Ser Glu Arg Met Val Ile Thr Gln
      50                  55                  60

 act gat cct gat gtc tct ccg gga aca aca aac ttg gac atc att gat      240
 Thr Asp Pro Asp Val Ser Pro Gly Thr Thr Asn Leu Asp Ile Ile Asp
  65                  70                  75                  80

 tta aaa ttc acg gat ttt ggg acg tac aca tgt gta gca tct ctg aag      288
 Leu Lys Phe Thr Asp Phe Gly Thr Tyr Thr Cys Val Ala Ser Leu Lys
                  85                  90                  95

 gga gga gga ata tct gat atc agt atc gat gtt aat ata tcc agc agc      336
 Gly Gly Gly Ile Ser Asp Ile Ser Ile Asp Val Asn Ile Ser Ser Ser
             100                 105                 110

 aca gtt cca ccc aat ctg act gtt cca cag gaa aaa tca cca ttg gtc      384
 Thr Val Pro Pro Asn Leu Thr Val Pro Gln Glu Lys Ser Pro Leu Val
         115                 120                 125

 acc aga gaa gga gac aca ata gaa ctg caa tgt caa gta act ggc aaa      432
 Thr Arg Glu Gly Asp Thr Ile Glu Leu Gln Cys Gln Val Thr Gly Lys
     130                 135                 140

 cct aaa cca atc atc ctt tgg tct aga gcg gat aaa gaa gtt gca atg      480
 Pro Lys Pro Ile Ile Leu Trp Ser Arg Ala Asp Lys Glu Val Ala Met
 145                 150                 155                 160

 cct gat gga tca atg caa atg gag agt tat gat gga aca ctg agg att      528
 Pro Asp Gly Ser Met Gln Met Glu Ser Tyr Asp Gly Thr Leu Arg Ile
                 165                 170                 175

 gtg aat gta tct agg gaa atg tca gga atg tac aga tgt cag acc agc      576
 Val Asn Val Ser Arg Glu Met Ser Gly Met Tyr Arg Cys Gln Thr Ser
             180                 185                 190

 caa tac aat gga ttt aac gtg aaa cca agg gaa gcc ttg gtg cag ctc      624
 Gln Tyr Asn Gly Phe Asn Val Lys Pro Arg Glu Ala Leu Val Gln Leu
         195                 200                 205

 atc gtt cag tat ccc cct gca gtg gaa cca gca ttc ttg gaa atc cgg      672
 Ile Val Gln Tyr Pro Pro Ala Val Glu Pro Ala Phe Leu Glu Ile Arg
     210                 215                 220

 caa gga cag gat cga agt gtc act atg agt tgc aga gta ctg aga gcc      720
 Gln Gly Gln Asp Arg Ser Val Thr Met Ser Cys Arg Val Leu Arg Ala
 225                 230                 235                 240

 tat cca ata cgg gtg ctg acc tat gag tgg cgc ttg ggc aat aaa tta      768
 Tyr Pro Ile Arg Val Leu Thr Tyr Glu Trp Arg Leu Gly Asn Lys Leu
                 245                 250                 255

 tta cgg acg ggt caa ttt gac tct cag gaa tac aca gag tac gct gtg      816
 Leu Arg Thr Gly Gln Phe Asp Ser Gln Glu Tyr Thr Glu Tyr Ala Val
             260                 265                 270

 aag agt ctt tcc aat gaa aac tat ggg gtt tat aac tgt agc atc ata      864
 Lys Ser Leu Ser Asn Glu Asn Tyr Gly Val Tyr Asn Cys Ser Ile Ile
         275                 280                 285

 aat gaa gct gga gct ggg aga tgc agc ttt ctt gtt aca gga aag gcc      912
 Asn Glu Ala Gly Ala Gly Arg Cys Ser Phe Leu Val Thr Gly Lys Ala
     290                 295                 300

 tat gct cca gaa ttc tat tat gat acc tac aat cca gta tgg cag aac      960
 Tyr Ala Pro Glu Phe Tyr Tyr Asp Thr Tyr Asn Pro Val Trp Gln Asn
 305                 310                 315                 320

 aga cac cgt gtt tat tct tac agt cta cag tgg aca cag atg aat cct     1008
 Arg His Arg Val Tyr Ser Tyr Ser Leu Gln Trp Thr Gln Met Asn Pro
                 325                 330                 335

 gat gca gtg gat cgg att gtt gca tac cgg ttg ggc atc agg cag gct     1056
 Asp Ala Val Asp Arg Ile Val Ala Tyr Arg Leu Gly Ile Arg Gln Ala
             340                 345                 350

 gga cag cag cgc tgg tgg gag cag gag att aaa ata aat ggg aat att     1104
 Gly Gln Gln Arg Trp Trp Glu Gln Glu Ile Lys Ile Asn Gly Asn Ile
         355                 360                 365

 caa aag gga gaa tta att aca tat aac ttg aca gag cta att aaa cca     1152
 Gln Lys Gly Glu Leu Ile Thr Tyr Asn Leu Thr Glu Leu Ile Lys Pro
     370                 375                 380

 gaa gct tat gaa gtc cga ctg act cct ctc acc aaa ttt ggt gaa gga     1200
 Glu Ala Tyr Glu Val Arg Leu Thr Pro Leu Thr Lys Phe Gly Glu Gly
 385                 390                 395                 400

 gat tca aca att cgt gtg atc aaa tat agt gct cct gta aat cct cat     1248
 Asp Ser Thr Ile Arg Val Ile Lys Tyr Ser Ala Pro Val Asn Pro His
                 405                 410                 415

 ttg aga gaa ttt cat tgt gga ttt gaa gat ggt aat att tgt ttg ttc     1296
 Leu Arg Glu Phe His Cys Gly Phe Glu Asp Gly Asn Ile Cys Leu Phe
             420                 425                 430

 act caa gat gat aca gat aat ttt gac tgg aca aag caa agt aca gca     1344
 Thr Gln Asp Asp Thr Asp Asn Phe Asp Trp Thr Lys Gln Ser Thr Ala
         435                 440                 445

 aca aga aat aca aaa tat act cct aat aca gga cct aat gct gac cgt     1392
 Thr Arg Asn Thr Lys Tyr Thr Pro Asn Thr Gly Pro Asn Ala Asp Arg
     450                 455                 460

 agt ggc tcc aaa gaa ggt ttt tat atg tac att gag aca tca cga ccc     1440
 Ser Gly Ser Lys Glu Gly Phe Tyr Met Tyr Ile Glu Thr Ser Arg Pro
 465                 470                 475                 480

 aga ttg gaa ggc gaa aag gct cga ctt ctc agc cct gtt ttc agc ata     1488
 Arg Leu Glu Gly Glu Lys Ala Arg Leu Leu Ser Pro Val Phe Ser Ile
                 485                 490                 495

 gct ccc aaa aac cct tat gga ccc aca aac act gca tat tgt ttc agc     1536
 Ala Pro Lys Asn Pro Tyr Gly Pro Thr Asn Thr Ala Tyr Cys Phe Ser
             500                 505                 510

 ttc ttt tat cac atg tat gga caa cat ata ggt gtc tta aat gtt tat     1584
 Phe Phe Tyr His Met Tyr Gly Gln His Ile Gly Val Leu Asn Val Tyr
         515                 520                 525

 cta cgt ttg aaa ggg caa aca aca ata gag aat cca ctg tgg tct tca     1632
 Leu Arg Leu Lys Gly Gln Thr Thr Ile Glu Asn Pro Leu Trp Ser Ser
     530                 535                 540

 agt ggg aat aaa gga caa aga tgg aat gag gct cat gtt aat ata tac     1680
 Ser Gly Asn Lys Gly Gln Arg Trp Asn Glu Ala His Val Asn Ile Tyr
 545                 550                 555                 560

 cca att act tca ttt cag ctc att ttt gaa ggt atc cga ggt cct gga     1728
 Pro Ile Thr Ser Phe Gln Leu Ile Phe Glu Gly Ile Arg Gly Pro Gly
                 565                 570                 575

 ata gaa ggt gac att gct att gat gat gta tca att gca gaa gga gaa     1776
 Ile Glu Gly Asp Ile Ala Ile Asp Asp Val Ser Ile Ala Glu Gly Glu
             580                 585                 590

 tgt gca aaa caa gac cta gca act aag aat tcc gtt gat ggt gct gtt     1824
 Cys Ala Lys Gln Asp Leu Ala Thr Lys Asn Ser Val Asp Gly Ala Val
         595                 600                 605

 ggg att ttg gtt cat ata tgg ctt ttt ccc att atc gtc ctc atc tct     1872
 Gly Ile Leu Val His Ile Trp Leu Phe Pro Ile Ile Val Leu Ile Ser
     610                 615                 620

 atc tta agt cct cga agg tga cc ttatcctggc agaggctata aaagattcac     1925
 Ile Leu Ser Pro Arg Arg 
 625                 630

 caggcactgg catgaagaaa gagtctttgt aaatggacat tgaacaaaca aactaccaaa   1985

 gattcctcca ctgactactg actcaaaaat aaaataataa aaacaaattt ttttaagcac   2045

 tggggataaa aagacatcat ggaagtataa cttattccag actaaacata aaagataatc   2105

 ttgacctgag tagagaagag accttcaggt gcttttgtgg ctaaaaagat tacagcgtca   2165

 tctggttgaa ctctggaaaa aaaaaaa                                       2192




      <210> 623
      <211> 3134
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (922)..(1368)

      <400> 623
 gtcgcccagg ctggagtgca gtggcgtgat ctcggctcac tgcaacctct gccttccggg     60

 ttcaagcaat tctcccacct cagcctcctg agtagctggg attacaggcg cccaccacca    120

 cagccggcta ctttttgtat ttttaggaga gacggggttt caccatgttg gtcaggctgg    180

 tcttgaactc ctgacctcat gatccacctg ccttagcctc ccaaagtgct gggattacag    240

 gcgtgagcca ccatgcccag ccctatagta gttcttcttt tgccccttaa tatcctcacc    300

 cacatgtcct gtaccctgcc tgaaccctcc tcctcttttt gttctgatct ttgagctccc    360

 tagagcccat aattctttag agcaggtatg tcccgagtct gaaacatgcc cttatttgtc    420

 ccaagctctg gacatttctc accccaaggc ggatcaatca tgattaaatc actccaatta    480

 aactttaggc tccagtcaga ccttcagcca aatggaaaaa aaaactaggg gataagggag    540

 gtagttggag caagaaaatg ttattagttg aaaccttacg ggaccttcct cccttagtga    600

 gtctgttggc taaaggttct ctggcttcgt gaattagaat cggatactgt ttccaagtta    660

 gcaaaaccaa ctctacccca gcaccccacg aggaagaatg tggaaggatc tcccattggc    720

 cggttggggc aaaagcctga ggcaatcttt catccccttt tgccaaggcg agactttccc    780

 agtgacggtg atgtagttgg ccactctgac tatgggtgga ctcgggtgta gacctctgaa    840

 gctgagatca cacgaaaacc tggcctcccc gccatgtagc tgttggagag tagaaaaata    900

 gagcacgcct gatgtttcta a  atg aga aga ctt tca ata gta atg aag aat     951
                          Met Arg Arg Leu Ser Ile Val Met Lys Asn
                            1               5                  10

 cca tgg cac tct cct cac cct caa aca cat ggc agt cat tca cat aca      999
 Pro Trp His Ser Pro His Pro Gln Thr His Gly Ser His Ser His Thr
                  15                  20                  25

 ggc ccc aaa gcc act gtt agt gct gca gta gct cct gtg gac att gga     1047
 Gly Pro Lys Ala Thr Val Ser Ala Ala Val Ala Pro Val Asp Ile Gly
              30                  35                  40

 aag ccc gga gag ggc gtg gaa gaa atc agc tgg ccc ccg gca ggt tct     1095
 Lys Pro Gly Glu Gly Val Glu Glu Ile Ser Trp Pro Pro Ala Gly Ser
          45                  50                  55

 ctg ggg ttt tgt gcc caa ggc tcc tgg agc cct aaa aac ttt caa aag     1143
 Leu Gly Phe Cys Ala Gln Gly Ser Trp Ser Pro Lys Asn Phe Gln Lys
      60                  65                  70

 tta act ccc cac gtc ccc atc ctg ctt ggg ttt ctg gac ttt tct gag     1191
 Leu Thr Pro His Val Pro Ile Leu Leu Gly Phe Leu Asp Phe Ser Glu
  75                  80                  85                  90

 gca ccg gca gag ggg tct cgt tgc tcc ctt gag tgt agg ggc agc cct     1239
 Ala Pro Ala Glu Gly Ser Arg Cys Ser Leu Glu Cys Arg Gly Ser Pro
                  95                 100                 105

 tta acc tgg ctc ctt gag tcc ctg ctt ttt ctg ctt ctg ttg cct tct     1287
 Leu Thr Trp Leu Leu Glu Ser Leu Leu Phe Leu Leu Leu Leu Pro Ser
             110                 115                 120

 tcc tcg tct tcc tct ctc tca ata tct ccc tct ctt tgt ccc tcc cca     1335
 Ser Ser Ser Ser Ser Leu Ser Ile Ser Pro Ser Leu Cys Pro Ser Pro
         125                 130                 135

 gtt cct gac ctg gcc atc ccg ggg tgc cct tga ccagcccc gtgtctcctc     1386
 Val Pro Asp Leu Ala Ile Pro Gly Cys Pro 
     140                 145

 agggtgtccc agcaccagcc tggcacagag tggggctcag ttagagtatg tgggatgttg   1446

 gtttcgccag gtgagtgaat gaaaggactc gaccaccaca gctgagccac tagctgggcc   1506

 atgcgaagag ttctaggtgc aaaggctgga gggtggaatt catttttgag aggtgtgtga   1566

 gcagcttccg acccctgccc catttgaacg ggggccttgc tggtcgcgtc cctgcattca   1626

 cccgcgcggc catcccgtca tccaacagtt gatcctaact gagcacgccc acggccctgg   1686

 tctggcctgg gcaccggcca ccgtagccca tcccttgatg gcctctgtgt ccccaggagg   1746

 gcgggccggg gggttgccca ggggctggag cagtggactg tggctccata gaggtaggcc   1806

 ggagggtgtg agggcagatt caagctatcc ccagggctct gctctggtcg gagccagccc   1866

 cttctccctc tctgccttcc ccgccccatt cctgatgctg aactgttctg gacccctggc   1926

 cctgagtctc tcaggaccaa agtgggcacg ggaacagctg tagtgtgtgc ccccccgggc   1986

 tttggccaca ggtctccctc tcgaggtgtg gttgtgactg cgacccttcc cttgccgtga   2046

 tgccttcctc ccccggggct tggtccagct ccttcactct ctagcagctg ctggggccca   2106

 cctcccatgc cgaggaccag caggggaaac ctccagggag catctgcagg ctctgcttct   2166

 gcccggctgc tggcttgctc tccctggtgg ctctccagcg gccagcttcc tcacccaccc   2226

 ggcactccgc tttgctctgt ctcctgaggt gggcctgacc aacctcccct tctctgcctc   2286

 agtccctggg ctccagggct cagctccaca gccctctgcc tagcaggctg gttctccctg   2346

 ccaagcccat acctgtggtc acctggccct cctgtggtct gagtaccact cccctgcccc   2406

 aggagccact cccactccag ctgcctgttt ccagcaggtt cccagtgccc ccgacaagcc   2466

 cctgctggtg tctccatctc ctgccaagca tcctccagtg cctcctcctg tgggcctggc   2526

 ctcagggcta tggacagact cctgtcccat cccagagacc cctcgtgatc gtgccctggc   2586

 acgtgggccg tggcccggct gggtcggctg aagaactgcg gatggaagct gcggaagagg   2646

 ccctgatggg gcccaccatc ccggacccaa gtcttcttcc tggcgggcct ctcgtctcct   2706

 tcctggtttg ggcggaagcc atcacctgga tgcctacgtg ggaagggacc tcgaatgtgg   2766

 gaccccagcc cctctccagc tcgaaatccc tccacagcca cggggacacc ctgcacctat   2826

 tcccacggga caggctggac ccagagactc tggacccggg gcctcccctt gagtagagac   2886

 ccgccctctg actgatggac gccgctgacc tggggtcaga cccgtgggct ggacccctgc   2946

 ccaccccgca ggaaccctga ggcctagggg agctgttgag ccttcagtgt ctgcatgtgg   3006

 gaagtgggct ccttcaccta cctcacaggg ctgttgtgag gggcgctgtg atgcggttcc   3066

 aaagcacagg gcttggcgca ccccactgtg ctctcaataa atgtgtttcc tgtcttaaca   3126

 aaaaaaaa                                                            3134




      <210> 624
      <211> 3300
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (508)..(2850)

      <400> 624
 cccggccgca gcagcaccgg ggtgataagt gtccagggca ggaggccagc gatgttgcct     60

 tgctaaccgg gtatctaaga gaaacagggt ctttttattc ttaggctcga cagtctgacg    120

 gccctttttc tgaacgggac cctgcaggtc ttccgcctgc tgttgcatta aatttggggg    180

 tggaagaggc ttctgcgttg ttccttaccc gcaacgatga ccatggcttt gccttcttta    240

 aaattgaggc ctccaactct gacgctgact ggagaattga aacccgaaca cacattgggc    300

 tcttttggca cttgactaga gctaaaacct cgggattcag cgggcaagcg ttgctcagca    360

 acggcgcgta ggctgtgtgc ggttggctgg agccagaccc caccccggcc tcggcccatg    420

 ctctagaggg gacgttgccc caatcctgaa ggacttcggc actcgagacc tgtggatgcc    480

 gcgttgctgt ggcctgcggg ggtgatc    atg aag cca ggt gct act ggc gag     531
                                  Met Lys Pro Gly Ala Thr Gly Glu
                                    1               5

 tcc gat ttg gcc gaa gtg ctg ccc cag cac aag ttc gac agc aag tcc      579
 Ser Asp Leu Ala Glu Val Leu Pro Gln His Lys Phe Asp Ser Lys Ser
      10                  15                  20

 ctg gag gcc tac cta aac cag cac ttg tct ggc ttt ggg gcc gaa cgt      627
 Leu Glu Ala Tyr Leu Asn Gln His Leu Ser Gly Phe Gly Ala Glu Arg
  25                  30                  35                  40

 gag gct acg ctg acc att gcc cag tac aga gca gga aag tcc aat cca      675
 Glu Ala Thr Leu Thr Ile Ala Gln Tyr Arg Ala Gly Lys Ser Asn Pro
                  45                  50                  55

 acc ttt tat ctc cag aag ggc ttt caa aca tat gtg ctc agg aaa aaa      723
 Thr Phe Tyr Leu Gln Lys Gly Phe Gln Thr Tyr Val Leu Arg Lys Lys
              60                  65                  70

 cca cca ggt tca ctt ctt cct aaa gca cat cag att gat aga gaa ttt      771
 Pro Pro Gly Ser Leu Leu Pro Lys Ala His Gln Ile Asp Arg Glu Phe
          75                  80                  85

 aaa gtc cag aaa gcc ttg ttt tca att gga ttc cct gtt ccc aag cct      819
 Lys Val Gln Lys Ala Leu Phe Ser Ile Gly Phe Pro Val Pro Lys Pro
      90                  95                 100

 ata ctg tac tgc agt gat act tct gtc att gga aca gaa ttt tac gta      867
 Ile Leu Tyr Cys Ser Asp Thr Ser Val Ile Gly Thr Glu Phe Tyr Val
 105                 110                 115                 120

 atg gaa cat gtg cag ggt cga atc ttc cgt gat tta aca att cct gga      915
 Met Glu His Val Gln Gly Arg Ile Phe Arg Asp Leu Thr Ile Pro Gly
                 125                 130                 135

 ctt agc cca gca gaa cgt tca gcc ata tat gtg gcc acg gta gaa aca      963
 Leu Ser Pro Ala Glu Arg Ser Ala Ile Tyr Val Ala Thr Val Glu Thr
             140                 145                 150

 ttg gct cag tta cat tcc ttg aat ata cag tca ctg cag ctg gaa gga     1011
 Leu Ala Gln Leu His Ser Leu Asn Ile Gln Ser Leu Gln Leu Glu Gly
         155                 160                 165

 tat ggt ata ggt gct ggg tac tgc aaa aga cag gta tca acc tgg aca     1059
 Tyr Gly Ile Gly Ala Gly Tyr Cys Lys Arg Gln Val Ser Thr Trp Thr
     170                 175                 180

 aag caa tat caa gct gca gct cat cag gac atc cct gcc atg caa cag     1107
 Lys Gln Tyr Gln Ala Ala Ala His Gln Asp Ile Pro Ala Met Gln Gln
 185                 190                 195                 200

 cta tcg gag tgg cta atg aag aac ttg ccc gat aat gac aat gaa gag     1155
 Leu Ser Glu Trp Leu Met Lys Asn Leu Pro Asp Asn Asp Asn Glu Glu
                 205                 210                 215

 aat ttg att cat gga gat ttc aga cta gat aac ata gtt ttc cac cct     1203
 Asn Leu Ile His Gly Asp Phe Arg Leu Asp Asn Ile Val Phe His Pro
             220                 225                 230

 aaa gag tgt cga gtt ata gca gtg ctg gat tgg gag ctg tca acc att     1251
 Lys Glu Cys Arg Val Ile Ala Val Leu Asp Trp Glu Leu Ser Thr Ile
         235                 240                 245

 ggt cat cct ttg tca gac tta gct cat ttt tcc ctg ttc tac ttt tgg     1299
 Gly His Pro Leu Ser Asp Leu Ala His Phe Ser Leu Phe Tyr Phe Trp
     250                 255                 260

 cca agg aca gtt cca atg ata aat caa ggt tct tat agt gaa aac tca     1347
 Pro Arg Thr Val Pro Met Ile Asn Gln Gly Ser Tyr Ser Glu Asn Ser
 265                 270                 275                 280

 ggg ata cca tca atg gaa gaa ctg att tca ata tat tgc cgc tgc agg     1395
 Gly Ile Pro Ser Met Glu Glu Leu Ile Ser Ile Tyr Cys Arg Cys Arg
                 285                 290                 295

 gga att aat tct att ctt cct aac tgg aat ttc ttt ctt gcc ctt tca     1443
 Gly Ile Asn Ser Ile Leu Pro Asn Trp Asn Phe Phe Leu Ala Leu Ser
             300                 305                 310

 tat ttt aag atg gct gga ata gca cag gga gta tat agc aga tat ctt     1491
 Tyr Phe Lys Met Ala Gly Ile Ala Gln Gly Val Tyr Ser Arg Tyr Leu
         315                 320                 325

 ctg gga aat aat tca tct gag gat agc ttt tta ttt gcc aat att gtg     1539
 Leu Gly Asn Asn Ser Ser Glu Asp Ser Phe Leu Phe Ala Asn Ile Val
     330                 335                 340

 caa cct ctg gca gaa act gga cta caa ctc tcc aaa cga act ttc agt     1587
 Gln Pro Leu Ala Glu Thr Gly Leu Gln Leu Ser Lys Arg Thr Phe Ser
 345                 350                 355                 360

 act gta cta cca cag att gat act act gga cag ttg ttt gta cag act     1635
 Thr Val Leu Pro Gln Ile Asp Thr Thr Gly Gln Leu Phe Val Gln Thr
                 365                 370                 375

 cgg aaa ggt cag gaa gtt ctt att aag gtg aag cat ttc atg aaa caa     1683
 Arg Lys Gly Gln Glu Val Leu Ile Lys Val Lys His Phe Met Lys Gln
             380                 385                 390

 cac att ctt cca gct gaa aag gag gta act gag ttc tat gtt caa aat     1731
 His Ile Leu Pro Ala Glu Lys Glu Val Thr Glu Phe Tyr Val Gln Asn
         395                 400                 405

 gaa aat tca gtg gac aag tgg gga aaa cct tta gtg att gat aaa ctc     1779
 Glu Asn Ser Val Asp Lys Trp Gly Lys Pro Leu Val Ile Asp Lys Leu
     410                 415                 420

 aag gaa atg gcc aaa gtc gag ggt ctc tgg aac ttg ttt ttg cca gct     1827
 Lys Glu Met Ala Lys Val Glu Gly Leu Trp Asn Leu Phe Leu Pro Ala
 425                 430                 435                 440

 gtc agc gga ctc agc cac gtg gac tat gcc ttg att gct gaa gaa aca     1875
 Val Ser Gly Leu Ser His Val Asp Tyr Ala Leu Ile Ala Glu Glu Thr
                 445                 450                 455

 gga aaa tgc ttt ttt gct cca gat gtc ttt aac tgc caa gca cca gac     1923
 Gly Lys Cys Phe Phe Ala Pro Asp Val Phe Asn Cys Gln Ala Pro Asp
             460                 465                 470

 aca ggg aat atg gag gtt ctg cac ctg tat gga agt gag gaa cag aag     1971
 Thr Gly Asn Met Glu Val Leu His Leu Tyr Gly Ser Glu Glu Gln Lys
         475                 480                 485

 aaa cag tgg ctt gag cct ctt ctt caa ggg aac att acc tct tgc ttc     2019
 Lys Gln Trp Leu Glu Pro Leu Leu Gln Gly Asn Ile Thr Ser Cys Phe
     490                 495                 500

 tgt atg aca gaa cct gat gta gct tca agt gat gcc acg aat att gaa     2067
 Cys Met Thr Glu Pro Asp Val Ala Ser Ser Asp Ala Thr Asn Ile Glu
 505                 510                 515                 520

 tgc agc atc caa cga gat gaa gat agc tat gta att aac ggc aaa aaa     2115
 Cys Ser Ile Gln Arg Asp Glu Asp Ser Tyr Val Ile Asn Gly Lys Lys
                 525                 530                 535

 tgg tgg agc agt gga gct ggg aat ccc aag tgc aaa gtt gca att gtt     2163
 Trp Trp Ser Ser Gly Ala Gly Asn Pro Lys Cys Lys Val Ala Ile Val
             540                 545                 550

 ttg gga aga act caa aat act tct ctc tcc aga cac aaa cag cac agc     2211
 Leu Gly Arg Thr Gln Asn Thr Ser Leu Ser Arg His Lys Gln His Ser
         555                 560                 565

 atg att ctt ggt ccc atg aac aca cct gga gta aaa ata ata agg cct     2259
 Met Ile Leu Gly Pro Met Asn Thr Pro Gly Val Lys Ile Ile Arg Pro
     570                 575                 580

 ttg tca gtt ttt ggc tac aca gat aat ttt cat gga gga cat ttt gag     2307
 Leu Ser Val Phe Gly Tyr Thr Asp Asn Phe His Gly Gly His Phe Glu
 585                 590                 595                 600

 atc cat ttt aat caa gtg cga gtt cct gcc aca aat cta ata cta ggt     2355
 Ile His Phe Asn Gln Val Arg Val Pro Ala Thr Asn Leu Ile Leu Gly
                 605                 610                 615

 gaa ggt agg gga ttt gaa att tcc caa ggc cgc ctt gga cct ggc aga     2403
 Glu Gly Arg Gly Phe Glu Ile Ser Gln Gly Arg Leu Gly Pro Gly Arg
             620                 625                 630

 atc cac cac tgt atg aga aca gta ggt ttg gcg gaa cgc gct ttg cag     2451
 Ile His His Cys Met Arg Thr Val Gly Leu Ala Glu Arg Ala Leu Gln
         635                 640                 645

 atc atg tgt gag cgg gca aca caa agg ata gct ttc aag aag aag ttg     2499
 Ile Met Cys Glu Arg Ala Thr Gln Arg Ile Ala Phe Lys Lys Lys Leu
     650                 655                 660

 tat gca cat gag gtt gtg gct cac tgg att gct gaa agc cgc att gcc     2547
 Tyr Ala His Glu Val Val Ala His Trp Ile Ala Glu Ser Arg Ile Ala
 665                 670                 675                 680

 att gag aag atc cgc ttg ttg act ctg aaa gct gct cac agc atg gac     2595
 Ile Glu Lys Ile Arg Leu Leu Thr Leu Lys Ala Ala His Ser Met Asp
                 685                 690                 695

 act ctg ggc agt gct ggc gct aag aaa gag att gca atg atc aaa gtg     2643
 Thr Leu Gly Ser Ala Gly Ala Lys Lys Glu Ile Ala Met Ile Lys Val
             700                 705                 710

 gct gcc cca cgg gct gtc agc aaa atc gtt gac tgg gcc atc cag gtg     2691
 Ala Ala Pro Arg Ala Val Ser Lys Ile Val Asp Trp Ala Ile Gln Val
         715                 720                 725

 tgc gga ggt gct ggt gtt tcc cag gat tac cct ctg gct aac atg tat     2739
 Cys Gly Gly Ala Gly Val Ser Gln Asp Tyr Pro Leu Ala Asn Met Tyr
     730                 735                 740

 gct ata acc cga gtt ttg cgt tta gca gat gga cct gac gaa gtt cat     2787
 Ala Ile Thr Arg Val Leu Arg Leu Ala Asp Gly Pro Asp Glu Val His
 745                 750                 755                 760

 ctt tca gca atc gca aca atg gag ctg cgg gac caa gcc aaa aga ctg     2835
 Leu Ser Ala Ile Ala Thr Met Glu Leu Arg Asp Gln Ala Lys Arg Leu
                 765                 770                 775

 aca gcc aag ata taa ggagggtggc actgccacat cccactggca gaaactctcc     2890
 Thr Ala Lys Ile 
             780

 tttatacaaa cttcattggc tccaacattt gaatctcata tttttgtagc agtttgagca   2950

 cagggttaat tattcatttg tggtaaagat tatagcatct attttgatca gtgggtttta   3010

 ttatttcaag ggtcacacag ggttaagttc agtaagaaat gctgtagctg ttgtcattca   3070

 atctagtgcc tccttgaggc caggagttca ggaccagcct gggcaacata gcgagacccc   3130

 cattgctaca aaaaatttaa aaatgaaaca agtgtggtgg cacatgcttg tagtcctagc   3190

 tacttgggag gctgaggcag gaggattgct tgagtctagg agtttgaggt tacagtaagc   3250

 tgtgatcgtg acatggcctc cagcctgggt gaccgagtga gactgtttct              3300




      <210> 625
      <211> 2768
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(2318)

      <400> 625
 ccgcgttgct gtggcctgcg ggggtgatc  atg aag cca ggt gct act ggc gag      53
                                  Met Lys Pro Gly Ala Thr Gly Glu
                                    1               5

 tcc gat ttg gcc gaa gtg ctg ccc cag cac aag ttc gac agc aag tcc      101
 Ser Asp Leu Ala Glu Val Leu Pro Gln His Lys Phe Asp Ser Lys Ser
      10                  15                  20

 ctg gag gcc tac cta aac cag cac ttg tct ggc ttt ggg gcc gaa cgt      149
 Leu Glu Ala Tyr Leu Asn Gln His Leu Ser Gly Phe Gly Ala Glu Arg
  25                  30                  35                  40

 gag gct acg ctg acc att gcc cag tac aga gca gga aag tcc aat cca      197
 Glu Ala Thr Leu Thr Ile Ala Gln Tyr Arg Ala Gly Lys Ser Asn Pro
                  45                  50                  55

 acc ttt tat ctc cag aag ggc ttt caa aca tat gtg ctc agg aaa gtc      245
 Thr Phe Tyr Leu Gln Lys Gly Phe Gln Thr Tyr Val Leu Arg Lys Val
              60                  65                  70

 cag aaa gcc ttg ttt tca att gga ttc cct gtt ccc aag cct ata ctg      293
 Gln Lys Ala Leu Phe Ser Ile Gly Phe Pro Val Pro Lys Pro Ile Leu
          75                  80                  85

 tac tgc agt gat act tct gtc att gga aca gaa ttt tac gta atg gaa      341
 Tyr Cys Ser Asp Thr Ser Val Ile Gly Thr Glu Phe Tyr Val Met Glu
      90                  95                 100

 cat gtg cag ggt cga atc ttc cgt gat tta aca att cct gga ctt agc      389
 His Val Gln Gly Arg Ile Phe Arg Asp Leu Thr Ile Pro Gly Leu Ser
 105                 110                 115                 120

 cca gca gaa cgt tca gcc ata tat gtg gcc acg gta gaa aca ttg gct      437
 Pro Ala Glu Arg Ser Ala Ile Tyr Val Ala Thr Val Glu Thr Leu Ala
                 125                 130                 135

 cag tta cat tcc ttg aat ata cag tca ctg cag ctg gaa gga tat ggt      485
 Gln Leu His Ser Leu Asn Ile Gln Ser Leu Gln Leu Glu Gly Tyr Gly
             140                 145                 150

 ata ggt gct ggg tac tgc aaa aga cag gta tca acc tgg aca aag caa      533
 Ile Gly Ala Gly Tyr Cys Lys Arg Gln Val Ser Thr Trp Thr Lys Gln
         155                 160                 165

 tat caa gct gca gct cat cag gac atc cct gcc atg caa cag cta tcg      581
 Tyr Gln Ala Ala Ala His Gln Asp Ile Pro Ala Met Gln Gln Leu Ser
     170                 175                 180

 gag tgg cta atg aag aac ttg ccc gat aat gac aat gaa gag aat ttg      629
 Glu Trp Leu Met Lys Asn Leu Pro Asp Asn Asp Asn Glu Glu Asn Leu
 185                 190                 195                 200

 att cat gga gat ttc aga cta gat aac ata gtt ttc cac cct aaa gag      677
 Ile His Gly Asp Phe Arg Leu Asp Asn Ile Val Phe His Pro Lys Glu
                 205                 210                 215

 tgt cga gtt ata gca gtg ctg gat tgg gag ctg tca acc att ggt cat      725
 Cys Arg Val Ile Ala Val Leu Asp Trp Glu Leu Ser Thr Ile Gly His
             220                 225                 230

 cct ttg tca gac tta gct cat ttt tcc ctg ttc tac ttt tgg cca agg      773
 Pro Leu Ser Asp Leu Ala His Phe Ser Leu Phe Tyr Phe Trp Pro Arg
         235                 240                 245

 aca gtt cca atg ata aat caa ggt tct tat agt gaa aac tca ggg ata      821
 Thr Val Pro Met Ile Asn Gln Gly Ser Tyr Ser Glu Asn Ser Gly Ile
     250                 255                 260

 cca tca atg gaa gaa ctg att tca ata tat tgc cgc tgc agg gga att      869
 Pro Ser Met Glu Glu Leu Ile Ser Ile Tyr Cys Arg Cys Arg Gly Ile
 265                 270                 275                 280

 aat tct att ctt cct aac tgg aat ttc ttt ctt gcc ctt tca tat ttt      917
 Asn Ser Ile Leu Pro Asn Trp Asn Phe Phe Leu Ala Leu Ser Tyr Phe
                 285                 290                 295

 aag atg gct gga ata gca cag gga gta tat agc aga tat ctt ctg gga      965
 Lys Met Ala Gly Ile Ala Gln Gly Val Tyr Ser Arg Tyr Leu Leu Gly
             300                 305                 310

 aat aat tca tct gag gat agc ttt tta ttt gcc aat att gtg caa cct     1013
 Asn Asn Ser Ser Glu Asp Ser Phe Leu Phe Ala Asn Ile Val Gln Pro
         315                 320                 325

 ctg gca gaa act gga cta caa ctc tcc aaa cga act ttc agt act gta     1061
 Leu Ala Glu Thr Gly Leu Gln Leu Ser Lys Arg Thr Phe Ser Thr Val
     330                 335                 340

 cta cca cag att gat act act gga cag ttg ttt gta cag act cgg aaa     1109
 Leu Pro Gln Ile Asp Thr Thr Gly Gln Leu Phe Val Gln Thr Arg Lys
 345                 350                 355                 360

 ggt cag gaa gtt ctt att aag gtg aag cat ttc atg aaa caa cac att     1157
 Gly Gln Glu Val Leu Ile Lys Val Lys His Phe Met Lys Gln His Ile
                 365                 370                 375

 ctt cca gct gaa aag gag gta act gag ttc tat gtt caa aat gaa aat     1205
 Leu Pro Ala Glu Lys Glu Val Thr Glu Phe Tyr Val Gln Asn Glu Asn
             380                 385                 390

 tca gtg gac aag tgg gga aaa cct tta gtg att gat aaa ctc aag gaa     1253
 Ser Val Asp Lys Trp Gly Lys Pro Leu Val Ile Asp Lys Leu Lys Glu
         395                 400                 405

 atg gcc aaa gtc gag ggt ctc tgg aac ttg ttt ttg cca gct gtc agc     1301
 Met Ala Lys Val Glu Gly Leu Trp Asn Leu Phe Leu Pro Ala Val Ser
     410                 415                 420

 gga ctc agc cac gtg gac tat gcc ttg att gct gaa gaa aca gga aaa     1349
 Gly Leu Ser His Val Asp Tyr Ala Leu Ile Ala Glu Glu Thr Gly Lys
 425                 430                 435                 440

 tgc ttt ttt gct cca gat gtc ttt aac tgc caa gca cca gac aca ggg     1397
 Cys Phe Phe Ala Pro Asp Val Phe Asn Cys Gln Ala Pro Asp Thr Gly
                 445                 450                 455

 aat atg gag gtt ctg cac ctg tat gga agt gag gaa cag aag aaa cag     1445
 Asn Met Glu Val Leu His Leu Tyr Gly Ser Glu Glu Gln Lys Lys Gln
             460                 465                 470

 tgg ctt gag cct ctt ctt caa ggg aac att acc tct tgc ttc tgt atg     1493
 Trp Leu Glu Pro Leu Leu Gln Gly Asn Ile Thr Ser Cys Phe Cys Met
         475                 480                 485

 aca gaa cct gat gta gct tca agt gat gcc acg aat att gaa tgc agc     1541
 Thr Glu Pro Asp Val Ala Ser Ser Asp Ala Thr Asn Ile Glu Cys Ser
     490                 495                 500

 atc caa cga gat gaa gat agc tat gta att aac ggc aaa aaa tgg tgg     1589
 Ile Gln Arg Asp Glu Asp Ser Tyr Val Ile Asn Gly Lys Lys Trp Trp
 505                 510                 515                 520

 agc agt gga gct ggg aat ccc aag tgc aaa gtt gca att gtt ttg gga     1637
 Ser Ser Gly Ala Gly Asn Pro Lys Cys Lys Val Ala Ile Val Leu Gly
                 525                 530                 535

 aga act caa aat act tct ctc tcc aga cac aaa cag cac agc atg att     1685
 Arg Thr Gln Asn Thr Ser Leu Ser Arg His Lys Gln His Ser Met Ile
             540                 545                 550

 ctt ggt ccc atg aac aca cct gga gta aaa ata ata agg cct ttg tca     1733
 Leu Gly Pro Met Asn Thr Pro Gly Val Lys Ile Ile Arg Pro Leu Ser
         555                 560                 565

 gtt ttt ggc tac aca gat aat ttt cat gga gga cat ttt gag atc cat     1781
 Val Phe Gly Tyr Thr Asp Asn Phe His Gly Gly His Phe Glu Ile His
     570                 575                 580

 ttt aat caa gtg cga gtt cct gcc aca aat cta ata cta ggt gaa ggt     1829
 Phe Asn Gln Val Arg Val Pro Ala Thr Asn Leu Ile Leu Gly Glu Gly
 585                 590                 595                 600

 agg gga ttt gaa att tcc caa ggc cgc ctt gga cct ggc aga atc cac     1877
 Arg Gly Phe Glu Ile Ser Gln Gly Arg Leu Gly Pro Gly Arg Ile His
                 605                 610                 615

 cac tgt atg aga aca gta ggt ttg gcg gaa cgc gct ttg cag atc atg     1925
 His Cys Met Arg Thr Val Gly Leu Ala Glu Arg Ala Leu Gln Ile Met
             620                 625                 630

 tgt gag cgg gca aca caa agg ata gct ttc aag aag aag ttg tat gca     1973
 Cys Glu Arg Ala Thr Gln Arg Ile Ala Phe Lys Lys Lys Leu Tyr Ala
         635                 640                 645

 cat gag gtt gtg gct cac tgg att gct gaa agc cgc att gcc att gag     2021
 His Glu Val Val Ala His Trp Ile Ala Glu Ser Arg Ile Ala Ile Glu
     650                 655                 660

 aag atc cgc ttg ttg act ctg aaa gct gct cac agc atg gac act ctg     2069
 Lys Ile Arg Leu Leu Thr Leu Lys Ala Ala His Ser Met Asp Thr Leu
 665                 670                 675                 680

 ggc agt gct ggc gct aag aaa gag att gca atg atc aaa gtg gct gcc     2117
 Gly Ser Ala Gly Ala Lys Lys Glu Ile Ala Met Ile Lys Val Ala Ala
                 685                 690                 695

 cca cgg gct gtc agc aaa atc gtt gac tgg gcc atc cag gtg tgc gga     2165
 Pro Arg Ala Val Ser Lys Ile Val Asp Trp Ala Ile Gln Val Cys Gly
             700                 705                 710

 ggt gct ggt gtt tcc cag gat tac cct ctg gct aac atg tat gct ata     2213
 Gly Ala Gly Val Ser Gln Asp Tyr Pro Leu Ala Asn Met Tyr Ala Ile
         715                 720                 725

 acc cga gtt ttg cgt tta gca gat gga cct gac gaa gtt cat ctt tca     2261
 Thr Arg Val Leu Arg Leu Ala Asp Gly Pro Asp Glu Val His Leu Ser
     730                 735                 740

 gca atc gca aca atg gag ctg cgg gac caa gcc aaa aga ctg aca gcc     2309
 Ala Ile Ala Thr Met Glu Leu Arg Asp Gln Ala Lys Arg Leu Thr Ala
 745                 750                 755                 760

 aag ata taa ggagggt ggcactgcca catcccactg gcagaaactc tcctttatac     2365
 Lys Ile 


 aaacttcatt ggctccaaca tttgaatctc atatttttgt agcagtttga gcacagggtt   2425

 aattattcat ttgtggtaaa gattatagca tctattttga tcagtgggtt ttattatttc   2485

 aagggtcaca cagggttaag ttcagtaaga aatgctgtag ctgttgtcat tcaatctagt   2545

 gcctccttga ggccaggagt tcaggaccag cctgggcaac atagcgagac ccccattgct   2605

 acaaaaaatt taaaaatgaa acaagtgtgg tggcacatgc ttgtagtcct agctacttgg   2665

 gaggctgagg caggaggatt gcttgagtct aggagtttga ggttacagta agctgtgatc   2725

 gtgacatggc ctccagcctg ggtgaccgag tgagactgtt tct                     2768




      <210> 626
      <211> 1481
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(707)

      <400> 626
 gagaacggct tccggcggga gctgtgcagc tccttatc    atg ggg aca att cat      53
                                              Met Gly Thr Ile His
                                                1               5

 ctc ttt cga aaa cca caa aga tcc ttt ttt ggc aag ttg tta cgg gaa      101
 Leu Phe Arg Lys Pro Gln Arg Ser Phe Phe Gly Lys Leu Leu Arg Glu
                  10                  15                  20

 ttt aga ctt gta gca gct gac cga agg tcc tgg aag ata ctg ctc ttt      149
 Phe Arg Leu Val Ala Ala Asp Arg Arg Ser Trp Lys Ile Leu Leu Phe
              25                  30                  35

 ggt gta ata aac ttg ata tgt act ggc ttc ctg ctt atg tgg tgc agt      197
 Gly Val Ile Asn Leu Ile Cys Thr Gly Phe Leu Leu Met Trp Cys Ser
          40                  45                  50

 tct act aat agg ata gct tta act gcc tat act tac ctg acc att ttt      245
 Ser Thr Asn Arg Ile Ala Leu Thr Ala Tyr Thr Tyr Leu Thr Ile Phe
      55                  60                  65

 gat ctt ttt agt tta atg aca tgt tta ata agt tac tgg gta aca ttg      293
 Asp Leu Phe Ser Leu Met Thr Cys Leu Ile Ser Tyr Trp Val Thr Leu
  70                  75                  80                  85

 agg aaa cct agc cct gtc tat tca ttt ggg ttt gaa aga tta gaa gtc      341
 Arg Lys Pro Ser Pro Val Tyr Ser Phe Gly Phe Glu Arg Leu Glu Val
                  90                  95                 100

 ctg gct gta ttt gcc tcc aca gtc ttg gca cag ttg gga gct ctc ttt      389
 Leu Ala Val Phe Ala Ser Thr Val Leu Ala Gln Leu Gly Ala Leu Phe
             105                 110                 115

 ata tta aaa gaa agt gca gaa cgc ttt ttg gaa cag ccc gag ata cac      437
 Ile Leu Lys Glu Ser Ala Glu Arg Phe Leu Glu Gln Pro Glu Ile His
         120                 125                 130

 acg gga aga tta tta gtt ggt act ttt gtg gct ctt tgt ttc aac ctg      485
 Thr Gly Arg Leu Leu Val Gly Thr Phe Val Ala Leu Cys Phe Asn Leu
     135                 140                 145

 ttc acg atg ctt tct att cgg aat aaa cct ttt gct tat gtc tca gaa      533
 Phe Thr Met Leu Ser Ile Arg Asn Lys Pro Phe Ala Tyr Val Ser Glu
 150                 155                 160                 165

 gct gct agt acg agc tgg ctt caa gag cat gtt gca gat ctt agt cga      581
 Ala Ala Ser Thr Ser Trp Leu Gln Glu His Val Ala Asp Leu Ser Arg
                 170                 175                 180

 agc ttg tgt gga att att ccg gga ctt agc agt atc ttc ctt ccc cga      629
 Ser Leu Cys Gly Ile Ile Pro Gly Leu Ser Ser Ile Phe Leu Pro Arg
             185                 190                 195

 atg aat cca ttt gtt ttg att gat ctt gct gga gca ttt gct ctt tgt      677
 Met Asn Pro Phe Val Leu Ile Asp Leu Ala Gly Ala Phe Ala Leu Cys
         200                 205                 210

 att aca tat atg ctc att gaa att aag tga g tattttttat tgttgtcaag      728
 Ile Thr Tyr Met Leu Ile Glu Ile Lys 
     215                 220

 tatgttttga tttctggggg acttactttt aagggcatca gcaggatgga tagtggtcaa    788

 gcttctagca gtttcgctta tgtcctgtgt aacttagatc acatcttttc cttaggtgtc    848

 ttcatctgaa aaattaaggg gattgggttc aataagtatt tcttaccaca atgtataatg    908

 cagactggaa aacaatttaa attccctact gctgacctga tgagtgaaac agacaaagag    968

 aacagtaaga aagagatctg agccaccact gctattgccg agagagggag gcagaagcag   1028

 gacgtaggcg tgaaacaatt ttttaacaaa taaaggcctt ttcggaaata ggctttacag   1088

 ctgctttaag cttaacttgt tatggcatat gatcttgggt acccaccttt taaatattag   1148

 tctttactag aatggtcctt attgtctggg ccgttatgta tttcttaaaa atcacatgca   1208

 gtatatggtt gttgctaatc ctgtgggatc ctaagattta ttctaggcca aattctattg   1268

 aattcaaagg gtatttcgac tgcatagggt ctcattaatg aaccatttct taactgaacg   1328

 ttgtttctat tcatttagat ggatacacaa actgcattgc caggacttta atggcaatac   1388

 acaaaggtag aagacaggcc agaagactat acatacccga tgacatgcac gaggaaagac   1448

 ctttaaggtg ggttgtttat aatatatctc ttg                                1481




      <210> 627
      <211> 6254
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2463)

      <400> 627
  atg gct gtg tac gtg ggg acg tgt gtg cgg tgt gtg cgc agt ggc gtg      48
  Met Ala Val Tyr Val Gly Thr Cys Val Arg Cys Val Arg Ser Gly Val
    1               5                  10                  15

 tgc ttg gct gtg ccc gtg ggg atg tgt gtg cgg cat ata cac att ggc       96
 Cys Leu Ala Val Pro Val Gly Met Cys Val Arg His Ile His Ile Gly
              20                  25                  30

 gtg tgc gtg gct gtg tgt gcg ggg acg tgt gtg cgg cgt gcg cgc att      144
 Val Cys Val Ala Val Cys Ala Gly Thr Cys Val Arg Arg Ala Arg Ile
          35                  40                  45

 ggc gtg tgc atg gct gtg cgc gcg ggg acg tgt gtg cgg cgt gca cgc      192
 Gly Val Cys Met Ala Val Arg Ala Gly Thr Cys Val Arg Arg Ala Arg
      50                  55                  60

 att ggc gtg tac ttg gct gtg cgc gcg ggg acg tgt gtg cgg cgt ata      240
 Ile Gly Val Tyr Leu Ala Val Arg Ala Gly Thr Cys Val Arg Arg Ile
  65                  70                  75                  80

 cgc att ggc gtg tgc gtg gct gtg cgt gcg ggg acg tgt gtg cgg cgt      288
 Arg Ile Gly Val Cys Val Ala Val Arg Ala Gly Thr Cys Val Arg Arg
                  85                  90                  95

 gcc cgc att ggc gtg tgc gtg gct gtg cgc gcg ggg acg tgt gtg cgg      336
 Ala Arg Ile Gly Val Cys Val Ala Val Arg Ala Gly Thr Cys Val Arg
             100                 105                 110

 cgt gcc cgc att ggc gtg tgc gtg gct gtg cgc gcg ggg acg tgt gtg      384
 Arg Ala Arg Ile Gly Val Cys Val Ala Val Arg Ala Gly Thr Cys Val
         115                 120                 125

 cgg cgt gca cgc att ggc gtg tgc gtg gct gtg cgc gcg ggg acg tgt      432
 Arg Arg Ala Arg Ile Gly Val Cys Val Ala Val Arg Ala Gly Thr Cys
     130                 135                 140

 gtg cgg cgt ata cgc att ggc gtg tgt gtg gct gtg cgc gcg ggg acc      480
 Val Arg Arg Ile Arg Ile Gly Val Cys Val Ala Val Arg Ala Gly Thr
 145                 150                 155                 160

 tgt gtg cgg cgt ata cgc att ggc gtg tgc gtg gct gtg cgc gcg ggg      528
 Cys Val Arg Arg Ile Arg Ile Gly Val Cys Val Ala Val Arg Ala Gly
                 165                 170                 175

 acc tgt gtg cgg cgt gcg cgc att ggc gtg tgc gtg gct gtg cgc gcg      576
 Thr Cys Val Arg Arg Ala Arg Ile Gly Val Cys Val Ala Val Arg Ala
             180                 185                 190

 ggg acg tgc gtg cgg cgt gcg cgc att ggc gtg tgc gtg gct gtg cgc      624
 Gly Thr Cys Val Arg Arg Ala Arg Ile Gly Val Cys Val Ala Val Arg
         195                 200                 205

 gcg ggg acg tgc gtg cgg cgt gcc cgc agt gtc gtg tgc gtg gct gtg      672
 Ala Gly Thr Cys Val Arg Arg Ala Arg Ser Val Val Cys Val Ala Val
     210                 215                 220

 cgc gcg ggg acg tgc gtg cgg cgt gcc cgc agt ggc gtg tgc gtg gct      720
 Arg Ala Gly Thr Cys Val Arg Arg Ala Arg Ser Gly Val Cys Val Ala
 225                 230                 235                 240

 gtg cgc gcg ggg acg tgc gtg cgg cgt gtg cgc att ggc gtg tac ttg      768
 Val Arg Ala Gly Thr Cys Val Arg Arg Val Arg Ile Gly Val Tyr Leu
                 245                 250                 255

 gct gtg cgc gcg ggg acg tgc gtg cgg cgt gtg cgc att ggc gtg tac      816
 Ala Val Arg Ala Gly Thr Cys Val Arg Arg Val Arg Ile Gly Val Tyr
             260                 265                 270

 ttg gct gtg cgc gcg ggg acg tgt gtg cgg cgt gtg cgc att ggc gtg      864
 Leu Ala Val Arg Ala Gly Thr Cys Val Arg Arg Val Arg Ile Gly Val
         275                 280                 285

 tgc gtg gct gtg tgc gcg ggg acg tgt gtg cgg cgt gcg cgc agt ggc      912
 Cys Val Ala Val Cys Ala Gly Thr Cys Val Arg Arg Ala Arg Ser Gly
     290                 295                 300

 gtg tgc gtg gct gtg cgc gtg ggg acg tgt gtg cgg cgt gcc cgc att      960
 Val Cys Val Ala Val Arg Val Gly Thr Cys Val Arg Arg Ala Arg Ile
 305                 310                 315                 320

 ggc gtg tgc gtg gct gtg tgc gcg ggg acg tgt gtg cgg cgt gtg cgc     1008
 Gly Val Cys Val Ala Val Cys Ala Gly Thr Cys Val Arg Arg Val Arg
                 325                 330                 335

 agc ttc gtg tgg atg gct gtg cat ggc cct tgt ttt ctt cag tca ttg     1056
 Ser Phe Val Trp Met Ala Val His Gly Pro Cys Phe Leu Gln Ser Leu
             340                 345                 350

 cac gtg cag aag agc gac gtg gac ctg atg aga acg aag ctc cgg cgc     1104
 His Val Gln Lys Ser Asp Val Asp Leu Met Arg Thr Lys Leu Arg Arg
         355                 360                 365

 ctg gag gag gaa aac agc agg aag gac cgg cag ata gag cag ctc ctg     1152
 Leu Glu Glu Glu Asn Ser Arg Lys Asp Arg Gln Ile Glu Gln Leu Leu
     370                 375                 380

 gat ccc agc cgc ggc acg gat ttt gtt cgg act ctg gca gag aaa agg     1200
 Asp Pro Ser Arg Gly Thr Asp Phe Val Arg Thr Leu Ala Glu Lys Arg
 385                 390                 395                 400

 ccc gat gcc agt tgg gtc att aac ggg ctg aag cag agg atc ctg aag     1248
 Pro Asp Ala Ser Trp Val Ile Asn Gly Leu Lys Gln Arg Ile Leu Lys
                 405                 410                 415

 ctg gaa cag cag tgc aag gag aag gac ggc acc atc agc aaa ctc cag     1296
 Leu Glu Gln Gln Cys Lys Glu Lys Asp Gly Thr Ile Ser Lys Leu Gln
             420                 425                 430

 acc gat atg aag act acc aac ctg gaa gag atg cgg atc gcc atg gag     1344
 Thr Asp Met Lys Thr Thr Asn Leu Glu Glu Met Arg Ile Ala Met Glu
         435                 440                 445

 aca tac tac gag gag gtg cat cgt ctc cag acc ctc ttg gca agt tct     1392
 Thr Tyr Tyr Glu Glu Val His Arg Leu Gln Thr Leu Leu Ala Ser Ser
     450                 455                 460

 gaa acc acc gga aag aag ccc ctg ggg gag aag aag acg ggc gcc aaa     1440
 Glu Thr Thr Gly Lys Lys Pro Leu Gly Glu Lys Lys Thr Gly Ala Lys
 465                 470                 475                 480

 agg cag aag aag atg ggc agt gcc ctc ctg agc ttg tcc cgg agt gtc     1488
 Arg Gln Lys Lys Met Gly Ser Ala Leu Leu Ser Leu Ser Arg Ser Val
                 485                 490                 495

 cag gag ctc acg gaa gag aac cag agc ctg aag gag gac ctg gac cgc     1536
 Gln Glu Leu Thr Glu Glu Asn Gln Ser Leu Lys Glu Asp Leu Asp Arg
             500                 505                 510

 gtg ctg agc acc tcc cca acc atc tcc aag aca cag ggt tat gtg gag     1584
 Val Leu Ser Thr Ser Pro Thr Ile Ser Lys Thr Gln Gly Tyr Val Glu
         515                 520                 525

 tgg agc aag ccc cgg ctg ctg agg cgc att gtg gag ctg gag aag aaa     1632
 Trp Ser Lys Pro Arg Leu Leu Arg Arg Ile Val Glu Leu Glu Lys Lys
     530                 535                 540

 cta agt gtg atg gag agc tca aaa tca cac gcc gca gag cca gtc aga     1680
 Leu Ser Val Met Glu Ser Ser Lys Ser His Ala Ala Glu Pro Val Arg
 545                 550                 555                 560

 tca cac ccg cca gcc tgc ctt gca tcc agc tct gcg ctg cac aga cag     1728
 Ser His Pro Pro Ala Cys Leu Ala Ser Ser Ser Ala Leu His Arg Gln
                 565                 570                 575

 cca cga ggg gac cgc aac aag gac cac gag cgt ctc cga ggg gct gtg     1776
 Pro Arg Gly Asp Arg Asn Lys Asp His Glu Arg Leu Arg Gly Ala Val
             580                 585                 590

 aga gac ctg aag gaa gag cgg acc gcg ctg cag gag cag ctg ctg cag     1824
 Arg Asp Leu Lys Glu Glu Arg Thr Ala Leu Gln Glu Gln Leu Leu Gln
         595                 600                 605

 aga gat ttg gag gtg aag cag ctc ctg cag gcg aag gcc gac ctg gag     1872
 Arg Asp Leu Glu Val Lys Gln Leu Leu Gln Ala Lys Ala Asp Leu Glu
     610                 615                 620

 aag gag ctg gag tgc gcg agg gag ggc gag gag gag agg aga gag cga     1920
 Lys Glu Leu Glu Cys Ala Arg Glu Gly Glu Glu Glu Arg Arg Glu Arg
 625                 630                 635                 640

 gag gag gtt ttg aga gag gag att cag aca ctt acc agc aag ctc caa     1968
 Glu Glu Val Leu Arg Glu Glu Ile Gln Thr Leu Thr Ser Lys Leu Gln
                 645                 650                 655

 gaa ttg caa gaa atg aag aaa gaa gag aaa gag gat tgc ccg gaa gtt     2016
 Glu Leu Gln Glu Met Lys Lys Glu Glu Lys Glu Asp Cys Pro Glu Val
             660                 665                 670

 cct cat aag gcc caa gag ctc cca gct ccc act ccc agc agc agg cac     2064
 Pro His Lys Ala Gln Glu Leu Pro Ala Pro Thr Pro Ser Ser Arg His
         675                 680                 685

 tgc gag caa gac tgg ccg ccg gat tcc agc gag gag ggg ctc ccg cgg     2112
 Cys Glu Gln Asp Trp Pro Pro Asp Ser Ser Glu Glu Gly Leu Pro Arg
     690                 695                 700

 ccc cgc tcc ccc tgc tct gat ggg aga aga gac gcc gcg gcc aga gtc     2160
 Pro Arg Ser Pro Cys Ser Asp Gly Arg Arg Asp Ala Ala Ala Arg Val
 705                 710                 715                 720

 ctg cag gcc cag tgg aag gtg tac aag cac aag aaa aaa aag gct gtt     2208
 Leu Gln Ala Gln Trp Lys Val Tyr Lys His Lys Lys Lys Lys Ala Val
                 725                 730                 735

 ctg gat gag gcg gct gtg gtg ctt cag gca gct ttc agg gga cat ctc     2256
 Leu Asp Glu Ala Ala Val Val Leu Gln Ala Ala Phe Arg Gly His Leu
             740                 745                 750

 acg cgg aca aag ctc tta gca agc aaa gca cat ggc tca gag cca ccc     2304
 Thr Arg Thr Lys Leu Leu Ala Ser Lys Ala His Gly Ser Glu Pro Pro
         755                 760                 765

 agc cgt gcc agg cct ccc aga cca gag ctc tcc tgt gcc ccg cgt tcc     2352
 Ser Arg Ala Arg Pro Pro Arg Pro Glu Leu Ser Cys Ala Pro Arg Ser
     770                 775                 780

 gag ccc cat cgc cca ggc cac ggg cag ccc tgt gca gga gga ggc cat     2400
 Glu Pro His Arg Pro Gly His Gly Gln Pro Cys Ala Gly Gly Gly His
 785                 790                 795                 800

 cgt cat cat cca gtc cgc tct gcg ggc aca cct ggc ccg ggc cag gca     2448
 Arg His His Pro Val Arg Ser Ala Gly Thr Pro Gly Pro Gly Gln Ala
                 805                 810                 815

 cag tgc tac cgg taa aagaaccacc accgcagctt ctaccaggag gagatcggct     2503
 Gln Cys Tyr Arg 
             820

 tcagccacac acggggacgc ctcctcccca cccttcctcg cagctcttcc tgacccctct   2563

 ccctcagggc cacaggccgt ggcacctcta cctggggatg acgtcaactc cgatgattcc   2623

 gacgatattg tcattgcacc gtctctgccc atgaagaact ttccagttta ggtccccgtc   2683

 actgtctcca cgccgtgatg gcagcgctgc cgaggacata ggaaccacga ctggaaagat   2743

 aatttatcgt gttaggagaa gaacgatgat acctacttaa cacctcagca tctgcgtcgt   2803

 gtctctttgt gcttttgttt gtggaaggag acccaaatgc ctttacttta ttctctgggg   2863

 agggccagcg gctcgcatcc ccctcatctc cagctgcagc tcggatggtg gattttcagt   2923

 gccaacagac acatctgccg tgaactcgca tatgccaggg agccctgtag tgacacgttc   2983

 tctgacagca ccttgccgcc tgcccacgac cttgaccgtg aggagctgct atccgcaacc   3043

 agcgccgaca ccatgccccc tcttcctggt gacaccctca acaaccagga tttgctccat   3103

 ctcagcccag caggccaggc agacacaccc cgctgtgcct taggaaggtg tgagaccggc   3163

 ttcccccatc cccacagcaa aacacggcct gtcccaagcc agtgaggagc taaagacacc   3223

 caggtcccca aatgatctta ctccatgccc cacccgctca caccgtcctt tcccgtcacc   3283

 cttgctatcc cctggagcac tgccctccag agctgccctt cccaggaagg aatttggttg   3343

 gattctgtca ctgtggagac caagattttt taaaattccc aattataatc acaaaagcag   3403

 catcacactt gcttctgaga acagcagggt gatgtctgtt cccaagctgg tggcgggagc   3463

 cttagcctgt gtggggccac ccggggaaga ggaggagagg agggtgagga ggcaggctcg   3523

 ccgttccaag ggacagcata ggctcgtggt ggggcgtgtt gcatctggtg tctgggacag   3583

 tccccgtcac cccatgtgtg cggcctctgc actcccaagc tccatggctg ggctgggctg   3643

 ggctgggctg ggctgggcgt gcggagcctg tggagccagc agctgcagag gcctaggagg   3703

 gagttcctgg gggaagcgca cagtgtccag tgcccatctc ttgcttgtgt gtgagattag   3763

 cccttgctgg ggcgtcaaga ggaagagcct tagacctggg caggccttca ggggcatcta   3823

 gacccctgca cagcccaggc ctggtgtctg catttccaca gcacccctgt ggggactcct   3883

 gccggggctg gccgctgtct caggagagac ccaatggtta gaaagcccct ttttacacag   3943

 ctgacagctt ctcccaaggc ttccgtccac ggggacaggc ttaacccctg ggcgcctttt   4003

 ctgcagcatg gcggccttct gagtcaccta agctgagcct ggggcattct ctgtggcggt   4063

 cagaaggccg atggccccaa cacagtggct tgtgaaaggg agagaggagg ctctgcatgt   4123

 ccacctgctc tatgggagga ggacacaggt gtccccagcc cagcctgttc tctcccagtc   4183

 actcaaggga tggggccacc caaagtgcag gacccgcccc accctgcggt tcgaagcctg   4243

 gcccctgtct ccacttagct tctgtttctg cagtgggtgg aagcgagtca gcgggggccc   4303

 tggcttgtgt acgtgttttc cttatttggt ctgtgggttg ccaagtccat ttttttttcc   4363

 actgaactgg ctggtaactt gatggactgt gtaactgaca caggccctct ttagacccct   4423

 gccttcaccc cacccgcccg ggtccactcc ctggggcgct gccccagcgt caagtgccaa   4483

 agcaggcccc atctaccact tcagggtcga cgttggtggc aggtgttgtt cacggtgtac   4543

 tgattgtcac tgcaacacct ccacatcacc ttgaacttca agaacagcag caaagctgta   4603

 tctgctatca gaggctgtta ggtagtccag ctttaaaata acacactctt tctctatccc   4663

 atgcccttta aacaagcagc cacaggagat gtcagtctcc agggcctggc cccactgtgt   4723

 tgacagcagt catgtctgtt gagctgacac tgctgaggct gaagctggcc ctgtgcaggt   4783

 ggctggtgag ccacaggtgc agtacccgga ggtgtgctct cccctagagg cctgtcccca   4843

 actcctcccc tagaggccta ttcccgctgc tcacagacct cagcagaggc accagctgga   4903

 gggctccagg gacatccttg gaaatacagg aggctttcct ggcacagggc acagctctta   4963

 ggaggccttt gtaggacgct gtctccccag cgtgtcctgc tcatccagga tggggagaaa   5023

 gaggaggagg ccccaggctc agaagccagg gacagactgc cgacgattac caaactgaat   5083

 ccaggcagtg ccatgaccct gggtgtccct tggttcacat cacccaccag acagctgcgg   5143

 agagagtgca gggaggggct gggaccaaac aggccagaaa ccagcagaaa agaggcagaa   5203

 gtgaggtggg tgtgcctggg gcacgaagcc agcgccgggg ggatttcagt ggagccttac   5263

 agccaggctc cgtgcggact gtgatgccag agaggcgtgc agcctctggg caagtcggga   5323

 gagggcttgg gtggtcccca caaggcagaa gaggtggaag ggccagagaa gaccaccaag   5383

 accaccgttc ccgcaggcct ggggtgagtg acctgactga gactagcggg cagagccaag   5443

 cagggctaaa ctccaaccca gggcccggtg ttggacaaag tagctttttc tttgctcgtt   5503

 tgtctgtgta ttaagaagag actaaaatag ccaaacgacg ctggtcgcat gcgctggctg   5563

 tggtctgtct gctgaatgtc tatttttgtc tcctgacgag acgtgaggac catgcccttg   5623

 atccctccga tggaccagaa acccccttcc ttgcaaaaaa aaggcaattg aattaggaaa   5683

 agatagacca acctagctca gatccaccaa gataagcaca gcaaagcttg gctgcatttt   5743

 tgaggaataa aaacctgcag aaagcaccga taaccttcaa gatctgaatg agattctatt   5803

 ataacccgtc taaacgattg caaaattcct cctttggttt tggaagcagc gtttgctctc   5863

 ccgtggctcg gattctctga ggaccaggga gttgacacac aaaccccgcc atgggtccga   5923

 gccagctatt tctcaaggct cccacctcgc caagctccca agggcctgct ggcagtgcct   5983

 acgctgtgcc aactaccctg tctggtacag accacggctg ggtaagcacc cttaaaagca   6043

 acagaaatga cgtctggaag ctgaaatgtg aaactgtcaa gatggcttag gagaggaagg   6103

 agtggacccg ctggtctttg gcattttgta tttagaatta ttctaacttt atacataatg   6163

 tataggccga tcttttggaa gggataaggt tttcattctt gtgcaactca ttattctcat   6223

 tattggcctt ttaaataaaa agttgttttg c                                  6254




      <210> 628
      <211> 1998
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (3)..(1910)

      <400> 628
 gc   atg aaa gct gat cgg aag cgc tta aag ggc gag aag aca gac ctg      47
      Met Lys Ala Asp Arg Lys Arg Leu Lys Gly Glu Lys Thr Asp Leu
        1               5                  10                  15

 gtg agc cag atg cag cag ctg tat gcc aca ctg gag agc cgc gag gag       95
 Val Ser Gln Met Gln Gln Leu Tyr Ala Thr Leu Glu Ser Arg Glu Glu
                  20                  25                  30

 cag ctc cga gac ttc atc cgc aac tat gag cag cac cgc aag gag agc      143
 Gln Leu Arg Asp Phe Ile Arg Asn Tyr Glu Gln His Arg Lys Glu Ser
              35                  40                  45

 gag gat gcg gtc aaa gcg ctg gcc aag gag aag gac ctg ctg gag cgt      191
 Glu Asp Ala Val Lys Ala Leu Ala Lys Glu Lys Asp Leu Leu Glu Arg
          50                  55                  60

 gag aag tgg gag ctg cgg cgc caa gcc aag gag gcc aca gac cac gcc      239
 Glu Lys Trp Glu Leu Arg Arg Gln Ala Lys Glu Ala Thr Asp His Ala
      65                  70                  75

 acg gca ctg cgc tcc cag ctg gac ctc aag gac aac cgg atg aag gag      287
 Thr Ala Leu Arg Ser Gln Leu Asp Leu Lys Asp Asn Arg Met Lys Glu
  80                  85                  90                  95

 ctg gag gcc gag ctg gcc atg gcc aaa cag tcc tta gct acg ctg acc      335
 Leu Glu Ala Glu Leu Ala Met Ala Lys Gln Ser Leu Ala Thr Leu Thr
                 100                 105                 110

 aag gac gtc ccc aag cgg cat tcc ctc gcc atg ccg ggc gag acg gtg      383
 Lys Asp Val Pro Lys Arg His Ser Leu Ala Met Pro Gly Glu Thr Val
             115                 120                 125

 ctc aat ggc aac cag gag tgg gtg gtg cag gcg gac ctc ccg ctg acc      431
 Leu Asn Gly Asn Gln Glu Trp Val Val Gln Ala Asp Leu Pro Leu Thr
         130                 135                 140

 gca gcc atc cgg cag agt caa cag act ctc tac cac tca cac ccc cct      479
 Ala Ala Ile Arg Gln Ser Gln Gln Thr Leu Tyr His Ser His Pro Pro
     145                 150                 155

 cac cct gcg gac cgg caa gcg gtc agg gtg agc ccc tgc cac tcc cgg      527
 His Pro Ala Asp Arg Gln Ala Val Arg Val Ser Pro Cys His Ser Arg
 160                 165                 170                 175

 cag ccc tct gtc atc tcc gac gca tct gcc gcc gaa ggc gac cgg tcg      575
 Gln Pro Ser Val Ile Ser Asp Ala Ser Ala Ala Glu Gly Asp Arg Ser
                 180                 185                 190

 tcc aca ccg agc gac atc aac tcc cct cga cac cgg aca cac tcc ctc      623
 Ser Thr Pro Ser Asp Ile Asn Ser Pro Arg His Arg Thr His Ser Leu
             195                 200                 205

 tgc aac ggc gac agt ccc ggc cca gtt cag aag aac ctg cac aac cct      671
 Cys Asn Gly Asp Ser Pro Gly Pro Val Gln Lys Asn Leu His Asn Pro
         210                 215                 220

 att gta cag tca cta gag gat ctt gaa gac caa aaa cgg aaa aag aag      719
 Ile Val Gln Ser Leu Glu Asp Leu Glu Asp Gln Lys Arg Lys Lys Lys
     225                 230                 235

 aaa gag aag atg gga ttc ggc tcc atc tcc cgc gtc ttc gcc aga ggg      767
 Lys Glu Lys Met Gly Phe Gly Ser Ile Ser Arg Val Phe Ala Arg Gly
 240                 245                 250                 255

 aag cag cgg aag tcc ctc gac ccc ggc ctc ttt gat gac tcg gac agc      815
 Lys Gln Arg Lys Ser Leu Asp Pro Gly Leu Phe Asp Asp Ser Asp Ser
                 260                 265                 270

 cag tgc agc ccc acg cgg cag agc ctc agc ctg tcg gaa ggc gag gag      863
 Gln Cys Ser Pro Thr Arg Gln Ser Leu Ser Leu Ser Glu Gly Glu Glu
             275                 280                 285

 cag atg gac cgg ctg cag cag gtg gag ctg gtg agg acc acc cct atg      911
 Gln Met Asp Arg Leu Gln Gln Val Glu Leu Val Arg Thr Thr Pro Met
         290                 295                 300

 tcc cac tgg aag gcg ggc acc gtc cag gcc tgg ctg gag gtg gtg atg      959
 Ser His Trp Lys Ala Gly Thr Val Gln Ala Trp Leu Glu Val Val Met
     305                 310                 315

 gcc atg cct atg tac gtc aag gcc tgc acg gag aac gtg aag agc ggg     1007
 Ala Met Pro Met Tyr Val Lys Ala Cys Thr Glu Asn Val Lys Ser Gly
 320                 325                 330                 335

 aag gtg ctg ctg agc ctg agt gac gag gac ctg cag ctg ggc ctt ggg     1055
 Lys Val Leu Leu Ser Leu Ser Asp Glu Asp Leu Gln Leu Gly Leu Gly
                 340                 345                 350

 gtg tgc agc tcc ctg cac cgg cgc aag ctg cgc ctg gcc atc gag gac     1103
 Val Cys Ser Ser Leu His Arg Arg Lys Leu Arg Leu Ala Ile Glu Asp
             355                 360                 365

 tac cgt gat gcc gag gca ggc cgc agc ctg tcc aaa gct gcc gag ctg     1151
 Tyr Arg Asp Ala Glu Ala Gly Arg Ser Leu Ser Lys Ala Ala Glu Leu
         370                 375                 380

 gac cat cac tgg gtg gcc aag gcc tgg ctg aat gac att ggc ctg tcc     1199
 Asp His His Trp Val Ala Lys Ala Trp Leu Asn Asp Ile Gly Leu Ser
     385                 390                 395

 cag tac tcc cag gcc ttt cag aac cac ctg gtt gat ggg cgg atg ctg     1247
 Gln Tyr Ser Gln Ala Phe Gln Asn His Leu Val Asp Gly Arg Met Leu
 400                 405                 410                 415

 aat tcc ctg atg aag cga gac ctg gag aag cac ctg aac gtg tcc aag     1295
 Asn Ser Leu Met Lys Arg Asp Leu Glu Lys His Leu Asn Val Ser Lys
                 420                 425                 430

 aag ttc cac cag gtc agc atc ctg ctg ggg atc gag ctg ctg tac caa     1343
 Lys Phe His Gln Val Ser Ile Leu Leu Gly Ile Glu Leu Leu Tyr Gln
             435                 440                 445

 gtg aac ttc agc agg gag gcc ctc cag gag cgc cgg gcc cgc tgc gag     1391
 Val Asn Phe Ser Arg Glu Ala Leu Gln Glu Arg Arg Ala Arg Cys Glu
         450                 455                 460

 acg cag aac att gac ccc gtg gtg tgg acc aac cag cgg gtg ctc aag     1439
 Thr Gln Asn Ile Asp Pro Val Val Trp Thr Asn Gln Arg Val Leu Lys
     465                 470                 475

 tgg gtt cga gac atc gac ctg aag gag tac gca gac aac ctg acc aac     1487
 Trp Val Arg Asp Ile Asp Leu Lys Glu Tyr Ala Asp Asn Leu Thr Asn
 480                 485                 490                 495

 agc ggc gtc cat ggt gct gtg ctg gtg ctg gag ccc aca ttc aat gcc     1535
 Ser Gly Val His Gly Ala Val Leu Val Leu Glu Pro Thr Phe Asn Ala
                 500                 505                 510

 gag gcc atg gcc act gcc ctg ggc atc ccc agt ggg aag cac atc ctc     1583
 Glu Ala Met Ala Thr Ala Leu Gly Ile Pro Ser Gly Lys His Ile Leu
             515                 520                 525

 cgg aga cac ctg gca gag gag atg agc gcc gtc ttc cac cca gcc aac     1631
 Arg Arg His Leu Ala Glu Glu Met Ser Ala Val Phe His Pro Ala Asn
         530                 535                 540

 tcc aca ggc atc cgg gag gct gag cgt ttt gga acg ccc cct ggc agg     1679
 Ser Thr Gly Ile Arg Glu Ala Glu Arg Phe Gly Thr Pro Pro Gly Arg
     545                 550                 555

 gcc tcc agc gtc acg cgg aca gga aag gag gag aac agc agc ggt ctc     1727
 Ala Ser Ser Val Thr Arg Thr Gly Lys Glu Glu Asn Ser Ser Gly Leu
 560                 565                 570                 575

 aag tac aag gct ggc cgg ctg ccc ctg ggg aag ata gga agg ggc ttc     1775
 Lys Tyr Lys Ala Gly Arg Leu Pro Leu Gly Lys Ile Gly Arg Gly Phe
                 580                 585                 590

 agc agc aaa gat ccc gat ttc cat gat gac tat ggc tct ctt caa aac     1823
 Ser Ser Lys Asp Pro Asp Phe His Asp Asp Tyr Gly Ser Leu Gln Asn
             595                 600                 605

 gaa gat tgc gga gac gat gac ccc cag agc agg ctg gaa cag tgc cgt     1871
 Glu Asp Cys Gly Asp Asp Asp Pro Gln Ser Arg Leu Glu Gln Cys Arg
         610                 615                 620

 ctg gaa ggc tac aac agc ctg gag gtc acc aac gtg taa ggaactggtg      1920
 Leu Glu Gly Tyr Asn Ser Leu Glu Val Thr Asn Val 
     625                 630                 635

 gctccaccag acccaacgtg agagacccag gaaggaagag aagccagatg gccccaggtg   1980

 tcgttctcac tgtacata                                                 1998




      <210> 629
      <211> 876
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(876)

      <400> 629
  atg agc atg cca ctg cat cag atc tct gcc att cca tcc cag gat gcc      48
  Met Ser Met Pro Leu His Gln Ile Ser Ala Ile Pro Ser Gln Asp Ala
    1               5                  10                  15

 atc tct gct aga gtc tac aga agt aag acc aaa gaa aag gag agg gaa       96
 Ile Ser Ala Arg Val Tyr Arg Ser Lys Thr Lys Glu Lys Glu Arg Glu
              20                  25                  30

 gaa cag aat gag aag act ttg gga cat ttc atg agt cat tca agc aac      144
 Glu Gln Asn Glu Lys Thr Leu Gly His Phe Met Ser His Ser Ser Asn
          35                  40                  45

 att tct aag gct ggg agt cct ccg tca gca tca gct ccg gct ccg gtg      192
 Ile Ser Lys Ala Gly Ser Pro Pro Ser Ala Ser Ala Pro Ala Pro Val
      50                  55                  60

 tcc tcc ttc tct cgc act tct atc acg cca tcc agc cag gac atc tgc      240
 Ser Ser Phe Ser Arg Thr Ser Ile Thr Pro Ser Ser Gln Asp Ile Cys
  65                  70                  75                  80

 agg atc tgc cac tgt gaa gga gat gat gag agc ccc ctg atc acc ccc      288
 Arg Ile Cys His Cys Glu Gly Asp Asp Glu Ser Pro Leu Ile Thr Pro
                  85                  90                  95

 tgc cac tgc aca gga agc ctc cac ttc gtg cac cag gcc tgc ctg cag      336
 Cys His Cys Thr Gly Ser Leu His Phe Val His Gln Ala Cys Leu Gln
             100                 105                 110

 cag tgg atc aag agc tcc gac acg cgc tgc tgc gag ctc tgc aag tat      384
 Gln Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr
         115                 120                 125

 gag ttc atc atg gag acc aag ctg aag cca ctg aga aaa tgg gag aag      432
 Glu Phe Ile Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys
     130                 135                 140

 ttg cag atg acg tcc agc gag cgc agg aag atc atg tgc tca gtg aca      480
 Leu Gln Met Thr Ser Ser Glu Arg Arg Lys Ile Met Cys Ser Val Thr
 145                 150                 155                 160

 ttc cac gtc att gcc atc aca tgt gtg gtc tgg tcc ttg tat gtg ctc      528
 Phe His Val Ile Ala Ile Thr Cys Val Val Trp Ser Leu Tyr Val Leu
                 165                 170                 175

 att gac cgt act gct gag gag atc aag cag ggg cag gca aca gga atc      576
 Ile Asp Arg Thr Ala Glu Glu Ile Lys Gln Gly Gln Ala Thr Gly Ile
             180                 185                 190

 cta gaa tgg ccc ttt tgg act aaa ttg gtg gtt gtg gcc atc ggc ttc      624
 Leu Glu Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala Ile Gly Phe
         195                 200                 205

 acc gga gga ctt ctt ttt atg tat gtt cag tgt aaa gtg tat gtg caa      672
 Thr Gly Gly Leu Leu Phe Met Tyr Val Gln Cys Lys Val Tyr Val Gln
     210                 215                 220

 ttg tgg aag aga ctc aag gcc tat aat aga gtg atc tat gtt caa aac      720
 Leu Trp Lys Arg Leu Lys Ala Tyr Asn Arg Val Ile Tyr Val Gln Asn
 225                 230                 235                 240

 tgt cca gaa aca agc aaa aag aat att ttt gaa aaa tct cca cta aca      768
 Cys Pro Glu Thr Ser Lys Lys Asn Ile Phe Glu Lys Ser Pro Leu Thr
                 245                 250                 255

 gag ccc aac ttt gaa aat aaa cat gga tat gga atc tgt cat tcc gac      816
 Glu Pro Asn Phe Glu Asn Lys His Gly Tyr Gly Ile Cys His Ser Asp
             260                 265                 270

 aca aac tct tct tgt tgc aca gag cct gaa gac act gga gca gaa atc      864
 Thr Asn Ser Ser Cys Cys Thr Glu Pro Glu Asp Thr Gly Ala Glu Ile
         275                 280                 285

 att cac gtc tga                                                      876
 Ile His Val 
     290





      <210> 630
      <211> 7500
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(6973)

      <400> 630
 ctctgaggaa ggcaaacaga aaggcaaggg cagcaaacct tta  atg cct acc tcc      55
                                                  Met Pro Thr Ser
                                                    1

 act atc ctt cgt ctt ctg gca gag ttg gtg agg tcc tat gtt ggt att      103
 Thr Ile Leu Arg Leu Leu Ala Glu Leu Val Arg Ser Tyr Val Gly Ile
   5                  10                  15                  20

 gct acc ctg att gcc aac tac agc tac act gtg ggc cag tct gaa ctg      151
 Ala Thr Leu Ile Ala Asn Tyr Ser Tyr Thr Val Gly Gln Ser Glu Leu
                  25                  30                  35

 atc aaa gag gac tgc agt gtg cta gct ttt gtt ctg gac cac ctg ctc      199
 Ile Lys Glu Asp Cys Ser Val Leu Ala Phe Val Leu Asp His Leu Leu
              40                  45                  50

 cca cat acc cag aat gca gaa gac aag gac acc cct gcc ttg gcc cgc      247
 Pro His Thr Gln Asn Ala Glu Asp Lys Asp Thr Pro Ala Leu Ala Arg
          55                  60                  65

 ctg ttc ctc gca agc ctg gct gct gca ggg agt ggc aca gat gcc cag      295
 Leu Phe Leu Ala Ser Leu Ala Ala Ala Gly Ser Gly Thr Asp Ala Gln
      70                  75                  80

 gtg gcc cta gtg aat gaa gta aaa gca gcc ctt gga cgg gca ctg gct      343
 Val Ala Leu Val Asn Glu Val Lys Ala Ala Leu Gly Arg Ala Leu Ala
  85                  90                  95                 100

 atg gct gag agt aca gag aaa cat gcc agg ctt cag gca gtg atg tgt      391
 Met Ala Glu Ser Thr Glu Lys His Ala Arg Leu Gln Ala Val Met Cys
                 105                 110                 115

 atc atc agt act atc atg gag tcc tgc ccc tcc acc tcc agc ttc tac      439
 Ile Ile Ser Thr Ile Met Glu Ser Cys Pro Ser Thr Ser Ser Phe Tyr
             120                 125                 130

 agc agt gcc aca gcg aag acc cag cac aat ggc atg aac aac atc att      487
 Ser Ser Ala Thr Ala Lys Thr Gln His Asn Gly Met Asn Asn Ile Ile
         135                 140                 145

 cgg ctt ttc ctg aag aag gga ctg gtt aat gac ctg gcc aga gta cct      535
 Arg Leu Phe Leu Lys Lys Gly Leu Val Asn Asp Leu Ala Arg Val Pro
     150                 155                 160

 cac agc tta gac ctg tcc agt ccc aac atg gcc aac aca gtc aat gct      583
 His Ser Leu Asp Leu Ser Ser Pro Asn Met Ala Asn Thr Val Asn Ala
 165                 170                 175                 180

 gct ctg aag cct ttg gaa aca ctt tcc cgg att gtg aac cag ccc agt      631
 Ala Leu Lys Pro Leu Glu Thr Leu Ser Arg Ile Val Asn Gln Pro Ser
                 185                 190                 195

 agc ctt ttt ggc agc aag agt gct tct agc aag aac aag tct gag cag      679
 Ser Leu Phe Gly Ser Lys Ser Ala Ser Ser Lys Asn Lys Ser Glu Gln
             200                 205                 210

 gat gcc caa gga gcc tct caa gat tcc agt agc aac cag cag gac cca      727
 Asp Ala Gln Gly Ala Ser Gln Asp Ser Ser Ser Asn Gln Gln Asp Pro
         215                 220                 225

 ggc gag cct ggg gaa gca gaa gtg cag gag gag gat cat gat gtc act      775
 Gly Glu Pro Gly Glu Ala Glu Val Gln Glu Glu Asp His Asp Val Thr
     230                 235                 240

 cag aca gag gtg gca gat ggg gat atc atg gat ggg gag gct gaa acc      823
 Gln Thr Glu Val Ala Asp Gly Asp Ile Met Asp Gly Glu Ala Glu Thr
 245                 250                 255                 260

 gac tca gtg gtg att gct ggg cag cct gag gtg ctc agt tca caa gag      871
 Asp Ser Val Val Ile Ala Gly Gln Pro Glu Val Leu Ser Ser Gln Glu
                 265                 270                 275

 atg cag gtt gag aat gag ctg gag gac ctg ata gat gag ttg ctt gag      919
 Met Gln Val Glu Asn Glu Leu Glu Asp Leu Ile Asp Glu Leu Leu Glu
             280                 285                 290

 agg gat ggc gga tct ggg aac agt aca att ata gtg agc aga agt gga      967
 Arg Asp Gly Gly Ser Gly Asn Ser Thr Ile Ile Val Ser Arg Ser Gly
         295                 300                 305

 gag gat gaa tca caa gag gac gtg ctg atg gat gaa gct cct tcc aac     1015
 Glu Asp Glu Ser Gln Glu Asp Val Leu Met Asp Glu Ala Pro Ser Asn
     310                 315                 320

 ctc agc caa gct tcc acc ttg cag gcc aac cga gaa gat tcc atg aat     1063
 Leu Ser Gln Ala Ser Thr Leu Gln Ala Asn Arg Glu Asp Ser Met Asn
 325                 330                 335                 340

 atc ctg gac cct gag gat gag gag gag cac act cag gaa gag gac agc     1111
 Ile Leu Asp Pro Glu Asp Glu Glu Glu His Thr Gln Glu Glu Asp Ser
                 345                 350                 355

 agt ggc agt aac gag gat gag gat gat agt cag gat gaa gag gag gag     1159
 Ser Gly Ser Asn Glu Asp Glu Asp Asp Ser Gln Asp Glu Glu Glu Glu
             360                 365                 370

 gag gag gaa gat gag gaa gat gat cag gag gat gat gaa ggt gaa gag     1207
 Glu Glu Glu Asp Glu Glu Asp Asp Gln Glu Asp Asp Glu Gly Glu Glu
         375                 380                 385

 gga gat gaa gac gat gac gac gat ggc tct gag atg gaa ttg gat gag     1255
 Gly Asp Glu Asp Asp Asp Asp Asp Gly Ser Glu Met Glu Leu Asp Glu
     390                 395                 400

 gat tat cct gat atg aac gct tct ccc ttg gtc cga ttt gag cgc ttt     1303
 Asp Tyr Pro Asp Met Asn Ala Ser Pro Leu Val Arg Phe Glu Arg Phe
 405                 410                 415                 420

 gac cgg gag gat gat ctc atc att gag ttt gac aac atg ttc tcc agt     1351
 Asp Arg Glu Asp Asp Leu Ile Ile Glu Phe Asp Asn Met Phe Ser Ser
                 425                 430                 435

 gct aca gac atc ccc cca tcc cca gga aat atc cct acc acc cat cca     1399
 Ala Thr Asp Ile Pro Pro Ser Pro Gly Asn Ile Pro Thr Thr His Pro
             440                 445                 450

 ctg atg gtg cgc cat gca gac cac agt tct ctg aca ctg ggc agt ggc     1447
 Leu Met Val Arg His Ala Asp His Ser Ser Leu Thr Leu Gly Ser Gly
         455                 460                 465

 tct tca aca act cgt ctc acc cag ggc atc ggg cgc agt cag agg acc     1495
 Ser Ser Thr Thr Arg Leu Thr Gln Gly Ile Gly Arg Ser Gln Arg Thr
     470                 475                 480

 cta agg cag ctg acg gcc aat gct ggc cac acc att cat gtt cac tac     1543
 Leu Arg Gln Leu Thr Ala Asn Ala Gly His Thr Ile His Val His Tyr
 485                 490                 495                 500

 cct ggg aat cgc cag ccc aac cct cct ctt ata ctg cag agg ttg ctt     1591
 Pro Gly Asn Arg Gln Pro Asn Pro Pro Leu Ile Leu Gln Arg Leu Leu
                 505                 510                 515

 ggt ccc tca gct gct gct gac atc ctt cag ctg agc agc agc ctt ccc     1639
 Gly Pro Ser Ala Ala Ala Asp Ile Leu Gln Leu Ser Ser Ser Leu Pro
             520                 525                 530

 cta caa agc cgg ggt cgg gcc cgc ctc ctg gta ggc aac gat gac gtc     1687
 Leu Gln Ser Arg Gly Arg Ala Arg Leu Leu Val Gly Asn Asp Asp Val
         535                 540                 545

 cac atc atc gcc cgt tct gat gat gag ctg ctg gat gac ttt ttc cat     1735
 His Ile Ile Ala Arg Ser Asp Asp Glu Leu Leu Asp Asp Phe Phe His
     550                 555                 560

 gat cag agc aca gct acc agc caa gca gga acc ctg tcc agc atc ccc     1783
 Asp Gln Ser Thr Ala Thr Ser Gln Ala Gly Thr Leu Ser Ser Ile Pro
 565                 570                 575                 580

 aca gcc ctg acc cgc tgg aca gaa gaa tgc aaa gtt ctc gat gct gag     1831
 Thr Ala Leu Thr Arg Trp Thr Glu Glu Cys Lys Val Leu Asp Ala Glu
                 585                 590                 595

 agc atg cat gac tgt gtt tca gtg gtt aaa gtg tcc att gtc aat cac     1879
 Ser Met His Asp Cys Val Ser Val Val Lys Val Ser Ile Val Asn His
             600                 605                 610

 ctg gaa ttc ctg agg gat gag gag ctg gaa gaa agg cga gag aag cgc     1927
 Leu Glu Phe Leu Arg Asp Glu Glu Leu Glu Glu Arg Arg Glu Lys Arg
         615                 620                 625

 agg aaa caa ctg gct gag gaa gaa aca aag ata act gat aaa ggc aaa     1975
 Arg Lys Gln Leu Ala Glu Glu Glu Thr Lys Ile Thr Asp Lys Gly Lys
     630                 635                 640

 gaa gat aag gag aac agg gat cag agt gca cag tgt act gca tct aag     2023
 Glu Asp Lys Glu Asn Arg Asp Gln Ser Ala Gln Cys Thr Ala Ser Lys
 645                 650                 655                 660

 tca aat gac tcc act gaa cag aat ctc tca gat ggg acg cct atg cct     2071
 Ser Asn Asp Ser Thr Glu Gln Asn Leu Ser Asp Gly Thr Pro Met Pro
                 665                 670                 675

 gac agc tac cca aca acc cca tct tca act gat gca gct aca tct gag     2119
 Asp Ser Tyr Pro Thr Thr Pro Ser Ser Thr Asp Ala Ala Thr Ser Glu
             680                 685                 690

 tcc aag gag acc ctt ggc act ctg caa tcc tca caa cag caa cca aca     2167
 Ser Lys Glu Thr Leu Gly Thr Leu Gln Ser Ser Gln Gln Gln Pro Thr
         695                 700                 705

 ctc cca acc cca cca gct ttg gga gag gtt cct cag gag ctg cag tct     2215
 Leu Pro Thr Pro Pro Ala Leu Gly Glu Val Pro Gln Glu Leu Gln Ser
     710                 715                 720

 cca gct gga gaa ggg ggc agc tct aca cag cta ttg atg cct gta gag     2263
 Pro Ala Gly Glu Gly Gly Ser Ser Thr Gln Leu Leu Met Pro Val Glu
 725                 730                 735                 740

 cca gag gaa ttg ggt ccc aca agg cca agt ggg gaa gca gaa aca act     2311
 Pro Glu Glu Leu Gly Pro Thr Arg Pro Ser Gly Glu Ala Glu Thr Thr
                 745                 750                 755

 cag atg gag tta tcc cca gct ccc act ata acc tca ctt tcc cca gag     2359
 Gln Met Glu Leu Ser Pro Ala Pro Thr Ile Thr Ser Leu Ser Pro Glu
             760                 765                 770

 aga gct gag gat tct gat gca ctg acg gct gtc agc agt cag cta gaa     2407
 Arg Ala Glu Asp Ser Asp Ala Leu Thr Ala Val Ser Ser Gln Leu Glu
         775                 780                 785

 ggc tct cct atg gat aca agc agc ctg gct tcc tgt acc tta gag gag     2455
 Gly Ser Pro Met Asp Thr Ser Ser Leu Ala Ser Cys Thr Leu Glu Glu
     790                 795                 800

 gct gtg ggt gac act tca gca gct ggc agt tct gag cag ccc aga gca     2503
 Ala Val Gly Asp Thr Ser Ala Ala Gly Ser Ser Glu Gln Pro Arg Ala
 805                 810                 815                 820

 ggc agc tcc act cct ggg gat gcc cca cca gct gtg gcg gaa gtg caa     2551
 Gly Ser Ser Thr Pro Gly Asp Ala Pro Pro Ala Val Ala Glu Val Gln
                 825                 830                 835

 ggc agg agt gat ggg tca ggg gaa tct gcc cag cca cct gag gac agc     2599
 Gly Arg Ser Asp Gly Ser Gly Glu Ser Ala Gln Pro Pro Glu Asp Ser
             840                 845                 850

 tcc cca cct gca tcc tct gag agc tct tcc acc aga gat tct gcc gtg     2647
 Ser Pro Pro Ala Ser Ser Glu Ser Ser Ser Thr Arg Asp Ser Ala Val
         855                 860                 865

 gcc att tct gga gca gat tcc cga gga atc cta gaa gag ccg ttg cct     2695
 Ala Ile Ser Gly Ala Asp Ser Arg Gly Ile Leu Glu Glu Pro Leu Pro
     870                 875                 880

 tca aca agc agt gaa gaa gaa gat ccc ctt gcg ggt atc agt ctc cct     2743
 Ser Thr Ser Ser Glu Glu Glu Asp Pro Leu Ala Gly Ile Ser Leu Pro
 885                 890                 895                 900

 gaa ggt gtg gac ccc tct ttt ctg gct gcc ctg cct gat gac atc cgt     2791
 Glu Gly Val Asp Pro Ser Phe Leu Ala Ala Leu Pro Asp Asp Ile Arg
                 905                 910                 915

 cgg gaa gtt cta cag aac cag cta ggc att cgt cca cca acc cgg act     2839
 Arg Glu Val Leu Gln Asn Gln Leu Gly Ile Arg Pro Pro Thr Arg Thr
             920                 925                 930

 gcc ccc tcc aca aat agc tca gcg cct gca gtg gtg ggg aat cct ggt     2887
 Ala Pro Ser Thr Asn Ser Ser Ala Pro Ala Val Val Gly Asn Pro Gly
         935                 940                 945

 gtg act gaa gtg agc cct gag ttt ctg gct gcc ctg cct cca gcc att     2935
 Val Thr Glu Val Ser Pro Glu Phe Leu Ala Ala Leu Pro Pro Ala Ile
     950                 955                 960

 cag gag gaa gta ctg gca cag cag aga gct gag cag cag cga cga gaa     2983
 Gln Glu Glu Val Leu Ala Gln Gln Arg Ala Glu Gln Gln Arg Arg Glu
 965                 970                 975                 980

 cta gca cag aat gcc agc tca gac acc cct atg gac cct gtg acc ttc     3031
 Leu Ala Gln Asn Ala Ser Ser Asp Thr Pro Met Asp Pro Val Thr Phe
                 985                 990                 995

 atc cag act ctg ccc tca gac ctg cgc cgt agt gtc cta gag gat atg     3079
 Ile Gln Thr Leu Pro Ser Asp Leu Arg Arg Ser Val Leu Glu Asp Met
            1000                1005                1010

 gag gac agt gtg tta gct gtg atg cca cct gac att gca gct gag gct     3127
 Glu Asp Ser Val Leu Ala Val Met Pro Pro Asp Ile Ala Ala Glu Ala
        1015                1020                1025

 caa gcc ctg aga cga gag caa gaa gcc cgg cag cga cag ctc atg cat     3175
 Gln Ala Leu Arg Arg Glu Gln Glu Ala Arg Gln Arg Gln Leu Met His
    1030                1035                1040

 gag cgt ctg ttt ggg cac agt agc acc tcc gca ctc tct gct att ctc     3223
 Glu Arg Leu Phe Gly His Ser Ser Thr Ser Ala Leu Ser Ala Ile Leu
1045                1050                1055                1060

 cga agc ccg gct ttc acc agt cgc tta agt ggc aac cgt ggg gtc cag     3271
 Arg Ser Pro Ala Phe Thr Ser Arg Leu Ser Gly Asn Arg Gly Val Gln
                1065                1070                1075

 tat act cgc ctt gct gtg cag aga ggt ggc acc ttc cag atg ggg ggt     3319
 Tyr Thr Arg Leu Ala Val Gln Arg Gly Gly Thr Phe Gln Met Gly Gly
            1080                1085                1090

 agc agc agc cat aac agg cct tct ggc agt aat gta gat act ctc ctc     3367
 Ser Ser Ser His Asn Arg Pro Ser Gly Ser Asn Val Asp Thr Leu Leu
        1095                1100                1105

 cgc ctc cga gga cgg ctc ctt ctg gac cac gaa gcc ctt tct tgt ctc     3415
 Arg Leu Arg Gly Arg Leu Leu Leu Asp His Glu Ala Leu Ser Cys Leu
    1110                1115                1120

 ttg gtc cta ctt ttt gtg gat gag cca aag ctc aat act agc cgt cta     3463
 Leu Val Leu Leu Phe Val Asp Glu Pro Lys Leu Asn Thr Ser Arg Leu
1125                1130                1135                1140

 cac cga gta ctg aga aat ctc tgc tac cat gcc cag acc cgc cac tgg     3511
 His Arg Val Leu Arg Asn Leu Cys Tyr His Ala Gln Thr Arg His Trp
                1145                1150                1155

 gtc atc cgc agt ctg ctc tcc atc ttg cag cgc agc agt gag agt gag     3559
 Val Ile Arg Ser Leu Leu Ser Ile Leu Gln Arg Ser Ser Glu Ser Glu
            1160                1165                1170

 cta tgc att gaa aca ccc aaa ctc act aca agt gag gaa aag ggc aaa     3607
 Leu Cys Ile Glu Thr Pro Lys Leu Thr Thr Ser Glu Glu Lys Gly Lys
        1175                1180                1185

 aag tcg agc aag agc tgt ggg tca agt agc cat gag aac cgt ccc ctg     3655
 Lys Ser Ser Lys Ser Cys Gly Ser Ser Ser His Glu Asn Arg Pro Leu
    1190                1195                1200

 gac ctg cta cac aag atg gag tca aag agc tcc aac cag ctt tcc tgg     3703
 Asp Leu Leu His Lys Met Glu Ser Lys Ser Ser Asn Gln Leu Ser Trp
1205                1210                1215                1220

 ctc tca gta tcc atg gat gca gcc cta ggc tgc agg act aat ata ttt     3751
 Leu Ser Val Ser Met Asp Ala Ala Leu Gly Cys Arg Thr Asn Ile Phe
                1225                1230                1235

 cag atc cag cgt tca ggg ggg cgt aaa cat acc gag aag cat gca agc     3799
 Gln Ile Gln Arg Ser Gly Gly Arg Lys His Thr Glu Lys His Ala Ser
            1240                1245                1250

 ggt ggc tcc acc gtc cac atc cat ccc caa gct gct cct gtt gtc tgc     3847
 Gly Gly Ser Thr Val His Ile His Pro Gln Ala Ala Pro Val Val Cys
        1255                1260                1265

 aga cac gtt ttg gat aca ctc att caa ttg gcc aag gta ttt ccc agc     3895
 Arg His Val Leu Asp Thr Leu Ile Gln Leu Ala Lys Val Phe Pro Ser
    1270                1275                1280

 cac ttc aca cag cag cgg acc aaa gaa aca aac tgt gag agt gat cgg     3943
 His Phe Thr Gln Gln Arg Thr Lys Glu Thr Asn Cys Glu Ser Asp Arg
1285                1290                1295                1300

 gaa agg ggc aat aag gcc tgt agc cca tgc tcc tca cag tcc tcc agc     3991
 Glu Arg Gly Asn Lys Ala Cys Ser Pro Cys Ser Ser Gln Ser Ser Ser
                1305                1310                1315

 agt ggc att tgc aca gac ttc tgg gac tta ttg gta aaa ctg gac aac     4039
 Ser Gly Ile Cys Thr Asp Phe Trp Asp Leu Leu Val Lys Leu Asp Asn
            1320                1325                1330

 atg aat gtc agc cgg aaa ggc aag aac tcc gtg aag tca gtg cca gtg     4087
 Met Asn Val Ser Arg Lys Gly Lys Asn Ser Val Lys Ser Val Pro Val
        1335                1340                1345

 agc gct ggc ggt gag ggg gaa acc tct cca tac agc ctc gag gcc tct     4135
 Ser Ala Gly Gly Glu Gly Glu Thr Ser Pro Tyr Ser Leu Glu Ala Ser
    1350                1355                1360

 cca ctg ggg cag ctc atg aac atg ttg tca cac cca gtc atc cgc cgg     4183
 Pro Leu Gly Gln Leu Met Asn Met Leu Ser His Pro Val Ile Arg Arg
1365                1370                1375                1380

 agc tct ctc tta act gag aaa ctc ctc aga ctc ctt tct ctc atc tca     4231
 Ser Ser Leu Leu Thr Glu Lys Leu Leu Arg Leu Leu Ser Leu Ile Ser
                1385                1390                1395

 att gct ctc cca gaa aac aag gtg tca gaa gca cag gct aat tct ggc     4279
 Ile Ala Leu Pro Glu Asn Lys Val Ser Glu Ala Gln Ala Asn Ser Gly
            1400                1405                1410

 agc ggt gct tcc tcc acc acc act gcc acc tca acc aca tct acc acc     4327
 Ser Gly Ala Ser Ser Thr Thr Thr Ala Thr Ser Thr Thr Ser Thr Thr
        1415                1420                1425

 acc acc act gcc gcc tcc acc acg ccc aca ccc cct act gca ccc acc     4375
 Thr Thr Thr Ala Ala Ser Thr Thr Pro Thr Pro Pro Thr Ala Pro Thr
    1430                1435                1440

 cct gtc act tct gct cca gcc ctg gtt gct gcc acg gct att tcc acc     4423
 Pro Val Thr Ser Ala Pro Ala Leu Val Ala Ala Thr Ala Ile Ser Thr
1445                1450                1455                1460

 att gtc gta gct gct tcg acc aca gtg act acc ccc acg act gct acc     4471
 Ile Val Val Ala Ala Ser Thr Thr Val Thr Thr Pro Thr Thr Ala Thr
                1465                1470                1475

 act act gtt tca att tct ccc act act aag ggc agc aaa tct cca gcg     4519
 Thr Thr Val Ser Ile Ser Pro Thr Thr Lys Gly Ser Lys Ser Pro Ala
            1480                1485                1490

 aag gtg agt gat ggg ggc agc agc agt aca gac ttt aag atg gtg tcc     4567
 Lys Val Ser Asp Gly Gly Ser Ser Ser Thr Asp Phe Lys Met Val Ser
        1495                1500                1505

 tct ggc ctc act gaa aac cag cta cag ctc tct gta gag gtg ttg aca     4615
 Ser Gly Leu Thr Glu Asn Gln Leu Gln Leu Ser Val Glu Val Leu Thr
    1510                1515                1520

 tcc cac tct tgt tct gag gaa ggc tta gag gat gca gcc aac gta cta     4663
 Ser His Ser Cys Ser Glu Glu Gly Leu Glu Asp Ala Ala Asn Val Leu
1525                1530                1535                1540

 ctg cag ctc tcc cgg ggg gac tct ggg acc cgg gac act gtt ctc aag     4711
 Leu Gln Leu Ser Arg Gly Asp Ser Gly Thr Arg Asp Thr Val Leu Lys
                1545                1550                1555

 ctg cta ctg aat gga gcc cgc cat ctg ggt tat acc ctt tgt aaa caa     4759
 Leu Leu Leu Asn Gly Ala Arg His Leu Gly Tyr Thr Leu Cys Lys Gln
            1560                1565                1570

 ata ggt acc ctg ctg gcc gag ctg cgg gaa tac aac ctc gag cag cag     4807
 Ile Gly Thr Leu Leu Ala Glu Leu Arg Glu Tyr Asn Leu Glu Gln Gln
        1575                1580                1585

 cgg cga gcc caa tgt gaa acc ctc tct cct gat ggc ctg cct gag gag     4855
 Arg Arg Ala Gln Cys Glu Thr Leu Ser Pro Asp Gly Leu Pro Glu Glu
    1590                1595                1600

 cag cca cag acc acc aag ctg aag ggc aaa atg cag agc agg ttt gac     4903
 Gln Pro Gln Thr Thr Lys Leu Lys Gly Lys Met Gln Ser Arg Phe Asp
1605                1610                1615                1620

 atg gct gag aat gtg gta att gtg gca tct cag aag cga cct ttg ggt     4951
 Met Ala Glu Asn Val Val Ile Val Ala Ser Gln Lys Arg Pro Leu Gly
                1625                1630                1635

 ggc cgg gag ctc cag ctg cct tct atg tcc atg ttg aca tcc aag aca     4999
 Gly Arg Glu Leu Gln Leu Pro Ser Met Ser Met Leu Thr Ser Lys Thr
            1640                1645                1650

 tct acc cag aag ttc ttc ttg agg gta cta cag gtc atc atc cag ctc     5047
 Ser Thr Gln Lys Phe Phe Leu Arg Val Leu Gln Val Ile Ile Gln Leu
        1655                1660                1665

 cgg gac gac acg cgc cgg gct aac aag aaa gcc aag cag aca ggc agg     5095
 Arg Asp Asp Thr Arg Arg Ala Asn Lys Lys Ala Lys Gln Thr Gly Arg
    1670                1675                1680

 cta ggt tcc tcc ggt tta ggc tca gct agc agc atc cag gca gct gtt     5143
 Leu Gly Ser Ser Gly Leu Gly Ser Ala Ser Ser Ile Gln Ala Ala Val
1685                1690                1695                1700

 cgg cag ctg gag gct gag gct gat gcc att ata caa atg gta cgt gag     5191
 Arg Gln Leu Glu Ala Glu Ala Asp Ala Ile Ile Gln Met Val Arg Glu
                1705                1710                1715

 ggt caa agg gcg cgg aga cag caa caa gca gca acg tcg gag tct agc     5239
 Gly Gln Arg Ala Arg Arg Gln Gln Gln Ala Ala Thr Ser Glu Ser Ser
            1720                1725                1730

 cag tca gag gcg tct gtc cgg agg gag gaa tca ccc atg gat gtg gac     5287
 Gln Ser Glu Ala Ser Val Arg Arg Glu Glu Ser Pro Met Asp Val Asp
        1735                1740                1745

 cag cca tct ccc agt gct caa gat act caa tcc att gcc tcc gat gga     5335
 Gln Pro Ser Pro Ser Ala Gln Asp Thr Gln Ser Ile Ala Ser Asp Gly
    1750                1755                1760

 acc cca cag ggg gag aag gaa aag gaa gaa aga cca cct gag tta ccc     5383
 Thr Pro Gln Gly Glu Lys Glu Lys Glu Glu Arg Pro Pro Glu Leu Pro
1765                1770                1775                1780

 ctg ctc agc gag cag ctg agt ttg gac gag ctg tgg gac atg ctt ggg     5431
 Leu Leu Ser Glu Gln Leu Ser Leu Asp Glu Leu Trp Asp Met Leu Gly
                1785                1790                1795

 gag tgt cta aag gaa cta gag gaa tcc cat gac cag cat gcg gtg cta     5479
 Glu Cys Leu Lys Glu Leu Glu Glu Ser His Asp Gln His Ala Val Leu
            1800                1805                1810

 gtg cta cag cct gct gtc gag gcc ttc ttt ctg gtc cat gcc aca gag     5527
 Val Leu Gln Pro Ala Val Glu Ala Phe Phe Leu Val His Ala Thr Glu
        1815                1820                1825

 cgg gag agc aag cct cct gtc cga gac acc cgt gag agc cag ctg gca     5575
 Arg Glu Ser Lys Pro Pro Val Arg Asp Thr Arg Glu Ser Gln Leu Ala
    1830                1835                1840

 cac atc aag gac gag cct cct cca ctc tcc cct gcc ccc tta acc cca     5623
 His Ile Lys Asp Glu Pro Pro Pro Leu Ser Pro Ala Pro Leu Thr Pro
1845                1850                1855                1860

 gcc acg cct tcc tcc ctt gac cca ttc ttc tcc cgg gag ccc tca tct     5671
 Ala Thr Pro Ser Ser Leu Asp Pro Phe Phe Ser Arg Glu Pro Ser Ser
                1865                1870                1875

 atg cac atc tcc tca agc ctg ccc cct gac aca cag aag ttc ctt cgc     5719
 Met His Ile Ser Ser Ser Leu Pro Pro Asp Thr Gln Lys Phe Leu Arg
            1880                1885                1890

 ttt gca gag act cac cgc act gtg tta aac cag atc cta cgg cag tcc     5767
 Phe Ala Glu Thr His Arg Thr Val Leu Asn Gln Ile Leu Arg Gln Ser
        1895                1900                1905

 acg acc cac ctt gct gat ggg cct ttt gct gtc ctg gta gac tac att     5815
 Thr Thr His Leu Ala Asp Gly Pro Phe Ala Val Leu Val Asp Tyr Ile
    1910                1915                1920

 cgt gtc ctc gac ttt gat gtc aag cgc aaa tat ttc cgc caa gag ctg     5863
 Arg Val Leu Asp Phe Asp Val Lys Arg Lys Tyr Phe Arg Gln Glu Leu
1925                1930                1935                1940

 gag cgt tta gat gag ggg ctc cgg aaa gaa gac atg gct gtg cat gtc     5911
 Glu Arg Leu Asp Glu Gly Leu Arg Lys Glu Asp Met Ala Val His Val
                1945                1950                1955

 cgt cgt gac cat gtg ttt gaa gac tcc tat cgt gag ctg cat cgc aaa     5959
 Arg Arg Asp His Val Phe Glu Asp Ser Tyr Arg Glu Leu His Arg Lys
            1960                1965                1970

 tcc ccc gaa gaa atg aag aat cga ttg tat ata gta ttt gaa gga gaa     6007
 Ser Pro Glu Glu Met Lys Asn Arg Leu Tyr Ile Val Phe Glu Gly Glu
        1975                1980                1985

 gaa ggg cag gat gct ggc ggg ctc ctg cgg gag tgg tat atg atc atc     6055
 Glu Gly Gln Asp Ala Gly Gly Leu Leu Arg Glu Trp Tyr Met Ile Ile
    1990                1995                2000

 tct cga gag atg ttt aac cct atg tat gcc ttg ttc cgt acc tca cct     6103
 Ser Arg Glu Met Phe Asn Pro Met Tyr Ala Leu Phe Arg Thr Ser Pro
2005                2010                2015                2020

 ggt gat cga gtc acc tac acc atc aat cca tct tcc cac tgc aac ccc     6151
 Gly Asp Arg Val Thr Tyr Thr Ile Asn Pro Ser Ser His Cys Asn Pro
                2025                2030                2035

 aac cac ctc agc tac ttc aag ttt gtc gga cgc att gtg gcc aaa gct     6199
 Asn His Leu Ser Tyr Phe Lys Phe Val Gly Arg Ile Val Ala Lys Ala
            2040                2045                2050

 gta tat gac aac cgt ctt ctg gag tgc tac ttt act cga tcc ttt tac     6247
 Val Tyr Asp Asn Arg Leu Leu Glu Cys Tyr Phe Thr Arg Ser Phe Tyr
        2055                2060                2065

 aaa cac atc ttg ggc aag tca gtc aga tat aca gat atg gag agt gaa     6295
 Lys His Ile Leu Gly Lys Ser Val Arg Tyr Thr Asp Met Glu Ser Glu
    2070                2075                2080

 gat tac cac ttc tac caa ggt ctg gtt tat ctg ctg gaa aat gat gtc     6343
 Asp Tyr His Phe Tyr Gln Gly Leu Val Tyr Leu Leu Glu Asn Asp Val
2085                2090                2095                2100

 tcc aca cta ggc tat gac ctc acc ttc agc act gag gtc caa gag ttt     6391
 Ser Thr Leu Gly Tyr Asp Leu Thr Phe Ser Thr Glu Val Gln Glu Phe
                2105                2110                2115

 gga gtt tgt gaa gtt cgt gac ctc aaa ccc aat ggg gcc aac atc ttg     6439
 Gly Val Cys Glu Val Arg Asp Leu Lys Pro Asn Gly Ala Asn Ile Leu
            2120                2125                2130

 gta aca gag gag aat aag aag gag tat gta cac ctg gta tgc cag atg     6487
 Val Thr Glu Glu Asn Lys Lys Glu Tyr Val His Leu Val Cys Gln Met
        2135                2140                2145

 aga atg aca gga gcc atc cgc aag cag ttg gcg gct ttc tta gaa ggc     6535
 Arg Met Thr Gly Ala Ile Arg Lys Gln Leu Ala Ala Phe Leu Glu Gly
    2150                2155                2160

 ttc tat gag atc att cca aag cgc ctc att tcc atc ttc act gag cag     6583
 Phe Tyr Glu Ile Ile Pro Lys Arg Leu Ile Ser Ile Phe Thr Glu Gln
2165                2170                2175                2180

 gag tta gag ctg ctt ata tca gga ctg ccc acc att gac atc gat gat     6631
 Glu Leu Glu Leu Leu Ile Ser Gly Leu Pro Thr Ile Asp Ile Asp Asp
                2185                2190                2195

 ctg aaa tcc aac act gaa tac cac aag tac cag tcc aac tct att cag     6679
 Leu Lys Ser Asn Thr Glu Tyr His Lys Tyr Gln Ser Asn Ser Ile Gln
            2200                2205                2210

 atc cag tgg ttc tgg aga gca ttg cgt tct ttc gat caa gct gac cgt     6727
 Ile Gln Trp Phe Trp Arg Ala Leu Arg Ser Phe Asp Gln Ala Asp Arg
        2215                2220                2225

 gcc aag ttc ctc cag ttt gtc acg ggt act tcc aag gta ccc ctg caa     6775
 Ala Lys Phe Leu Gln Phe Val Thr Gly Thr Ser Lys Val Pro Leu Gln
    2230                2235                2240

 ggc ttt gct gcc ctc gaa ggc atg aat ggc att cag aag ttt cag atc     6823
 Gly Phe Ala Ala Leu Glu Gly Met Asn Gly Ile Gln Lys Phe Gln Ile
2245                2250                2255                2260

 cat cga gat gac agg tcc aca gat cgc ctg cct tca gct cac aca tgt     6871
 His Arg Asp Asp Arg Ser Thr Asp Arg Leu Pro Ser Ala His Thr Cys
                2265                2270                2275

 ttt aat cag ctg gat ctg cct gcc tat gag agc ttt gag aag ctc cgc     6919
 Phe Asn Gln Leu Asp Leu Pro Ala Tyr Glu Ser Phe Glu Lys Leu Arg
            2280                2285                2290

 cac atg cta ctg ttg gct atc cag gag tgc tct gaa ggc ttt ggg ctg     6967
 His Met Leu Leu Leu Ala Ile Gln Glu Cys Ser Glu Gly Phe Gly Leu
        2295                2300                2305

 gcc taa taaggccctg cccaactccg tggggttttt tttaccattg ttggacctgg      7023
 Ala 


 ggagggggga gttaaaaaaa gaaccagaaa gaaattgtca aaaaccaata aatgaaatcc   7083

 accaactcac cgtgtgtgtc ccagctgccc catcttcccc agcgcatacc tgttcctctt   7143

 ctcattctct ccccgccgcc tgtttcctca ccttctctcc cctttccatg ccgtccatga   7203

 tccccacccc atgtgtttta aaaaggcagt agcctttgca gggacctgtc tgtcccaact   7263

 gtttgaacag tgtgctcctc agattctgtg ttcagaagga tttgctgcat tgagacttga   7323

 aacctttgga taggggaaaa aattatatat atatatattt ttttgttctg tttgcatttc   7383

 ttaatttgtg cttggaatgt gttgatgtgc acagctaatg attcaatgcg agacaagatt   7443

 ggcgtctgtg ttgtggaggt ttcaaataaa gagcactctt cataaaaaaa aaaaaaa      7500




      <210> 631
      <211> 1169
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (138)..(878)

      <400> 631
 gatatcagct ggatggcaaa taatgatttt attttgactg atagtgacct gttcgttgca     60

 acaaattgat aagcaatgct ttcttataat gccaactttg tacaaaaaag ctgggtcggc    120

 gcgccgcccc cttcacc   atg ggg aag gcg gcg gcg gcg gtg gcc ttt ggg     170
                      Met Gly Lys Ala Ala Ala Ala Val Ala Phe Gly
                        1               5                  10

 gcc gaa gtg ggc gtg cgg ctc gcg ctg ttc gcg gcc ttc ctg gtg acg      218
 Ala Glu Val Gly Val Arg Leu Ala Leu Phe Ala Ala Phe Leu Val Thr
              15                  20                  25

 gag ctg ctc ccc ccg ttc cag aga ctc atc cag ccg gag gag atg tgg      266
 Glu Leu Leu Pro Pro Phe Gln Arg Leu Ile Gln Pro Glu Glu Met Trp
          30                  35                  40

 ctc tac cgg aac ccc tac gtg gag gcg gag tat ttc ccc acc aag ccg      314
 Leu Tyr Arg Asn Pro Tyr Val Glu Ala Glu Tyr Phe Pro Thr Lys Pro
      45                  50                  55

 atg ttt gtt att gca ttt ctc tct cca ctg tct ctg atc ttc ctg gcc      362
 Met Phe Val Ile Ala Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala
  60                  65                  70                  75

 aaa ttt ctc aag aag gca gac aca aga gac agc aga caa gcc tgc ctg      410
 Lys Phe Leu Lys Lys Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu
                  80                  85                  90

 gct gcc agc ctt gcc ctg gct ctg aat ggc gtc ttt acc aac aca att      458
 Ala Ala Ser Leu Ala Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile
              95                 100                 105

 ggg cta gcc cat tct gac ttg atg tgt aca ggg gat aag gac gtg gtg      506
 Gly Leu Ala His Ser Asp Leu Met Cys Thr Gly Asp Lys Asp Val Val
         110                 115                 120

 aat gag ggc cga aag agc ttc ccc agt gga cat tct tcc ttt gca ttt      554
 Asn Glu Gly Arg Lys Ser Phe Pro Ser Gly His Ser Ser Phe Ala Phe
     125                 130                 135

 gct ggt ctg gcc ttt gcg tcc ttc tac ctg gca ggg aag tta cac tgc      602
 Ala Gly Leu Ala Phe Ala Ser Phe Tyr Leu Ala Gly Lys Leu His Cys
 140                 145                 150                 155

 ttc aca cca caa ggc cgt ggg aaa tct tgg agg ttc tgt gcc ttt ctg      650
 Phe Thr Pro Gln Gly Arg Gly Lys Ser Trp Arg Phe Cys Ala Phe Leu
                 160                 165                 170

 tca cct cta ctt ttt gca gct gtg att gca ctg tcc cgc aca tgt gac      698
 Ser Pro Leu Leu Phe Ala Ala Val Ile Ala Leu Ser Arg Thr Cys Asp
             175                 180                 185

 tac aag cat cac tgg caa gat gta cta gtt gga tcc atg att gga atg      746
 Tyr Lys His His Trp Gln Asp Val Leu Val Gly Ser Met Ile Gly Met
         190                 195                 200

 aca ttt gcc tat gtc tgc tat cgg cag tat tat cct cct ctg act gat      794
 Thr Phe Ala Tyr Val Cys Tyr Arg Gln Tyr Tyr Pro Pro Leu Thr Asp
     205                 210                 215

 gca gaa tgc cat aaa cca ttt caa gac aaa ctt gta ctt tcc act gca      842
 Ala Glu Cys His Lys Pro Phe Gln Asp Lys Leu Val Leu Ser Thr Ala
 220                 225                 230                 235

 cag aag cct ggg gat tct tat tgt ttt gat att taa aaat tgaatctggc      892
 Gln Lys Pro Gly Asp Ser Tyr Cys Phe Asp Ile 
                 240                 245

 cgggcgtggt ggctcatgcc tgtaatccca acactttggg aggctgagga gggtggatca    952

 cctgaggtca ggaccagcct ggccaacatg gtgaaccctg tctctactaa aaatacaaaa   1012

 attagccagg agttgtgtgc cgtaatccca gctacctggg aggctgaggt aggagaattg   1072

 cttgaacctg ggagctggag gttccagtga gccgagatcg caccactgca ctccagcctg   1132

 ggcaacagag tgagacccca tctcaaaaaa aaaaaaa                            1169




      <210> 632
      <211> 852
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(852)

      <400> 632
 tttcttataa tgccaacttt gtacaagaaa gctgggtcgg cgcgcccacc cttcacc        57                                                                 
 atg ggg aag gcg gcg gcg gcg gtg gcc ttt ggg gcc gaa gtg ggc gtg      105
 Met Gly Lys Ala Ala Ala Ala Val Ala Phe Gly Ala Glu Val Gly Val
   1               5                  10                  15

 cgg ctc gcg ctg ttc gcg gcc ttc ctg gtg acg gag ctg ctc ccc ccg      153
 Arg Leu Ala Leu Phe Ala Ala Phe Leu Val Thr Glu Leu Leu Pro Pro
              20                  25                  30

 ttc cag aga ctc atc cag ccg gag gag atg tgg ctc tac cgg aac ccc      201
 Phe Gln Arg Leu Ile Gln Pro Glu Glu Met Trp Leu Tyr Arg Asn Pro
          35                  40                  45

 tac gtg gag gcg gag tat ttc ccc acc aag ccg atg ttt gtt att gca      249
 Tyr Val Glu Ala Glu Tyr Phe Pro Thr Lys Pro Met Phe Val Ile Ala
      50                  55                  60

 ttt ctc tct cca ctg tct ctg atc ttc ctg gcc aaa ttt ctc aag aag      297
 Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala Lys Phe Leu Lys Lys
  65                  70                  75                  80

 gca gac aca aga gac agc aga caa gcc tgc ctg gct gcc agc ctt gcc      345
 Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu Ala Ala Ser Leu Ala
                  85                  90                  95

 ctg gct ctg aat ggc gtc ttt acc aac aca ata aaa ctg atc gta ggg      393
 Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile Lys Leu Ile Val Gly
             100                 105                 110

 agg cca cgc cca gat ttc ttc tac cgc tgc ttc cct gat ggg cta gcc      441
 Arg Pro Arg Pro Asp Phe Phe Tyr Arg Cys Phe Pro Asp Gly Leu Ala
         115                 120                 125

 cat tct gac ttg atg tgt aca ggg gat aag gac gtg gtg aat gag ggc      489
 His Ser Asp Leu Met Cys Thr Gly Asp Lys Asp Val Val Asn Glu Gly
     130                 135                 140

 cga aag agc ttc ccc agt gga cat tct tcc ttt gca ttt gct ggt ctg      537
 Arg Lys Ser Phe Pro Ser Gly His Ser Ser Phe Ala Phe Ala Gly Leu
 145                 150                 155                 160

 gcc ttt gcg tcc ttc tac ctg gca ggg aag tta cac tgc ttc aca cca      585
 Ala Phe Ala Ser Phe Tyr Leu Ala Gly Lys Leu His Cys Phe Thr Pro
                 165                 170                 175

 caa ggc cgt ggg aaa tct tgg agg ttc tgt gcc ttt ctg tca cct cta      633
 Gln Gly Arg Gly Lys Ser Trp Arg Phe Cys Ala Phe Leu Ser Pro Leu
             180                 185                 190

 ctt ttt gca gct gtg att gca ctg tcc cgc aca tgt gac tac aag cat      681
 Leu Phe Ala Ala Val Ile Ala Leu Ser Arg Thr Cys Asp Tyr Lys His
         195                 200                 205

 cac tgg caa gat gta cta gtc gga tcc atg att gga atg aca ttt gcc      729
 His Trp Gln Asp Val Leu Val Gly Ser Met Ile Gly Met Thr Phe Ala
     210                 215                 220

 tat gtc tgc tat cgg cag tat tat cct cct ctg act gat gca gaa tgc      777
 Tyr Val Cys Tyr Arg Gln Tyr Tyr Pro Pro Leu Thr Asp Ala Glu Cys
 225                 230                 235                 240

 cat aaa cca ttt caa gac aaa ctt gta ctt tcc act aca cag aag cct      825
 His Lys Pro Phe Gln Asp Lys Leu Val Leu Ser Thr Thr Gln Lys Pro
                 245                 250                 255

 ggg gat tct tat tgt ttt gat att taa                                  852
 Gly Asp Ser Tyr Cys Phe Asp Ile 
             260





      <210> 633
      <211> 923
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (95)..(772)

      <400> 633
 ctgcggtctc ctgtgtgctg ctctctgtgg ggtcctgtag acccagagag gctcagctgc     60

 actcgcccgg ctgggagagc tgggtgtggg gaac    atg gcc ggg cct ccg agg     112
                                          Met Ala Gly Pro Pro Arg
                                            1               5

 ctc ctg ctg ctg ccc ctg ctt ctg gcg ctg gct cgc ggc ctg cct ggg      160
 Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu Ala Arg Gly Leu Pro Gly
              10                  15                  20

 gcc ctg gct gcc caa gag gtg cag cag tct ccc cac tgc acg act gtc      208
 Ala Leu Ala Ala Gln Glu Val Gln Gln Ser Pro His Cys Thr Thr Val
          25                  30                  35

 ccc gtg gga gcc tcc gtc aac atc acc tgc tcc acc agc ggg ggc ctg      256
 Pro Val Gly Ala Ser Val Asn Ile Thr Cys Ser Thr Ser Gly Gly Leu
      40                  45                  50

 cgt ggg atc tac ctg agg cag ctc ggg cca cag ccc caa gac atc att      304
 Arg Gly Ile Tyr Leu Arg Gln Leu Gly Pro Gln Pro Gln Asp Ile Ile
  55                  60                  65                  70

 tac tac gag gac ggg gtg gtg ccc act acg gac aga cgg ttc cgg ggc      352
 Tyr Tyr Glu Asp Gly Val Val Pro Thr Thr Asp Arg Arg Phe Arg Gly
                  75                  80                  85

 cgc atc gac ttc tca ggg tcc cag gac aac ctg act atc acc atg cac      400
 Arg Ile Asp Phe Ser Gly Ser Gln Asp Asn Leu Thr Ile Thr Met His
              90                  95                 100

 cgc ctg cag ctg tcg gac act ggc acc tac acc tgc cag gcc atc acg      448
 Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr Thr Cys Gln Ala Ile Thr
         105                 110                 115

 gag gtc aat gtc tac ggc tcc ggc acc ctg gtc ctg gtg aca gag gaa      496
 Glu Val Asn Val Tyr Gly Ser Gly Thr Leu Val Leu Val Thr Glu Glu
     120                 125                 130

 cag tcc caa gga tgg cac aga tgc tcg gac gcc cca cca agg gcc tct      544
 Gln Ser Gln Gly Trp His Arg Cys Ser Asp Ala Pro Pro Arg Ala Ser
 135                 140                 145                 150

 gcc ctc cct gcc ctc cct gac ccg cca gca gcc tct gcc ctc cct gcg      592
 Ala Leu Pro Ala Leu Pro Asp Pro Pro Ala Ala Ser Ala Leu Pro Ala
                 155                 160                 165

 gcc ctg gcg gtg atc tcc ttc ctc ctc ggg ctg ggc ctg ggg gtg gcg      640
 Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly Leu Gly Val Ala
             170                 175                 180

 tgt gtg ctg gcg agg aca cag ata aag aaa ctg tgc tcg tgg cgg gat      688
 Cys Val Leu Ala Arg Thr Gln Ile Lys Lys Leu Cys Ser Trp Arg Asp
         185                 190                 195

 aag aat tcg gcg gca tgt gtg gtg tac gag gac atg tcg cac agc cgc      736
 Lys Asn Ser Ala Ala Cys Val Val Tyr Glu Asp Met Ser His Ser Arg
     200                 205                 210

 tgc aac acg ctg tcc tcc ccc aac cag tac cag tga ccca gtgggcccct      786
 Cys Asn Thr Leu Ser Ser Pro Asn Gln Tyr Gln 
 215                 220                 225

 gcacgtcccg cctgtggtcc ccccagcacc ttccatgcag aaacacagag agaaaaaaga    846

 taaagaaaaa aaagaaaaga acaaaaaaaa aacaaaaaga aaaaacagac aaagaagaga    906

 caacaaaaaa aaaaaaa                                                   923




      <210> 634
      <211> 961
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (481)..(858)

      <400> 634
 atttgcttcc gcttgctgtt gagttggact ggcttggacg ctggccagga gcccaagtgg     60

 acttggtgct tctctttgac agccgggatt gaaaatccca gtcaagtggc cagagcgcga    120

 gggtgagatt taggagacct ggatgtcctc actttgccgc ccaggaactg ctgtgtgact    180

 ttcaccaagt gggacaacct ctctgaacta cgtttacccc ggctataaaa tggaggtgtt    240

 ggattggctg ccacaagtgt ccttccacct ccacaatacc gtgactggag cgggttttca    300

 ctcctttttc ttgttagcat aactgttgga gctatagagg gtttggagtg gggtgtgggt    360

 ttctgggcca cagatgtgtg aggctccgca cttagccagc agtggcaact ccttatcact    420

 ggtgcccacg gcttcatctg tgccctgaag atactaatgc tgcggtgact ggtcagatta    480
                                                                 
 atg gtg atg ctt tca tgg ggc gcc gta aga cat gcc cgc gag gta ttt      528
 Met Val Met Leu Ser Trp Gly Ala Val Arg His Ala Arg Glu Val Phe
   1               5                  10                  15

 cac cca tac aat ggg agg cag tgt tcc agt ctg ttg gag aca gga aag      576
 His Pro Tyr Asn Gly Arg Gln Cys Ser Ser Leu Leu Glu Thr Gly Lys
              20                  25                  30

 gga ggc tca gtc cct gcg aag gaa ctt tcc cga gtt cac aca gca ttt      624
 Gly Gly Ser Val Pro Ala Lys Glu Leu Ser Arg Val His Thr Ala Phe
          35                  40                  45

 cag cac cgg gtg gcc tgg ctt cag agt ttc aga ggg agg ggt ggc cct      672
 Gln His Arg Val Ala Trp Leu Gln Ser Phe Arg Gly Arg Gly Gly Pro
      50                  55                  60

 tcc tgt cgg tcc tgg ggg tct cct gga gtc agg acc ctt ggg aaa ccc      720
 Ser Cys Arg Ser Trp Gly Ser Pro Gly Val Arg Thr Leu Gly Lys Pro
  65                  70                  75                  80

 aaa tcc acc agg acg ctt gca tca gga gaa cct gac cac atg aga agc      768
 Lys Ser Thr Arg Thr Leu Ala Ser Gly Glu Pro Asp His Met Arg Ser
                  85                  90                  95

 tgc cct ttt ctg gtt ctc ctg ctt acc ctc gac ttg ggg tgt cgg caa      816
 Cys Pro Phe Leu Val Leu Leu Leu Thr Leu Asp Leu Gly Cys Arg Gln
             100                 105                 110

 att tca gag ctt gcc aaa tct gca tct tcc tgg cct gtt taa aatgaat      865
 Ile Ser Glu Leu Ala Lys Ser Ala Ser Ser Trp Pro Val 
         115                 120                 125

 gtgtcagccc cattctggac agcagctgac acctcttccc ccgtgccagc caggacagtg    925

 tggttgggcg taactcagcc ccggttaaaa aaaaaa                              961




      <210> 635
      <211> 2546
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (505)..(1890)

      <400> 635
 agcggggaca gcgatgctca gctggctgcg gccgagtcat cgcctagcgc tggcagggcc     60

 gctgaccgac cgacggaggc gccgattggc cgattgtcca ctgcgcagaa ggagcagctg    120

 ctccgcgccc cgccgcgccg cgctgaggcc gaggtccgca gggccgcggg gaagccgagg    180

 gctgccggag aaccctgcag gtgtcactcg ggacgcggaa gtgcgcttgc cgaggtttgc    240

 cttacaatac gcttgagact ccccgacaag cgtaatttgg tcgagttcga cgggaaagta    300

 ctctccccac cccagcgccg gccgcgtagt ccgaggttac tgtccccggc gcgtcctctg    360

 ttgccccagt ccagaggctg cccttgaacc cgggcgcgca cgagcgcagg gcatccgagg    420

 cgacagcccc tggcacggcc cgacctgtac ccagcctggc aggaagactg taatcgtggg    480

 aatacagcta cctacccagg caat   atg aag att tta ttt gta gaa cct gcc     531
                              Met Lys Ile Leu Phe Val Glu Pro Ala
                                1               5

 att ttc ctt agt gca ttt gct atg act ttg acc ggt cca ctg aca acg      579
 Ile Phe Leu Ser Ala Phe Ala Met Thr Leu Thr Gly Pro Leu Thr Thr
  10                  15                  20                  25

 caa tat gtt tat cgg aga ata tgg gaa gaa act ggc aac tac act ttt      627
 Gln Tyr Val Tyr Arg Arg Ile Trp Glu Glu Thr Gly Asn Tyr Thr Phe
                  30                  35                  40

 tca tct gat agc aat att tct gag tgt gaa aaa aac aaa agc agc cca      675
 Ser Ser Asp Ser Asn Ile Ser Glu Cys Glu Lys Asn Lys Ser Ser Pro
              45                  50                  55

 att ttt gca ttc cag gag gaa gtt cag aaa aaa gtg tca cgt ttt aat      723
 Ile Phe Ala Phe Gln Glu Glu Val Gln Lys Lys Val Ser Arg Phe Asn
          60                  65                  70

 ctg cag atg gac ata agt gga tta att cct ggt cta gtg tct aca ttc      771
 Leu Gln Met Asp Ile Ser Gly Leu Ile Pro Gly Leu Val Ser Thr Phe
      75                  80                  85

 ata ctt ttg tct att agt gat cac tac gga cga aaa ttc cct atg att      819
 Ile Leu Leu Ser Ile Ser Asp His Tyr Gly Arg Lys Phe Pro Met Ile
  90                  95                 100                 105

 ttg tct tcc gtt ggt gct ctt gca acc agc gtt tgg ctc tgt ttg ctt      867
 Leu Ser Ser Val Gly Ala Leu Ala Thr Ser Val Trp Leu Cys Leu Leu
                 110                 115                 120

 tgc tat ttt gcc ttt cca ttc cag ctt ttg att gca tct acc ttc att      915
 Cys Tyr Phe Ala Phe Pro Phe Gln Leu Leu Ile Ala Ser Thr Phe Ile
             125                 130                 135

 ggt gca ttt tgt ggc aat tat acc aca ttt tgg gga gct tgc ttt gcc      963
 Gly Ala Phe Cys Gly Asn Tyr Thr Thr Phe Trp Gly Ala Cys Phe Ala
         140                 145                 150

 tat ata gtt gat cag tgt aaa gaa cac aaa caa aaa aca att cga ata     1011
 Tyr Ile Val Asp Gln Cys Lys Glu His Lys Gln Lys Thr Ile Arg Ile
     155                 160                 165

 gct atc att gac ttt cta ctt gga ctt gtt act gga cta aca gga ctg     1059
 Ala Ile Ile Asp Phe Leu Leu Gly Leu Val Thr Gly Leu Thr Gly Leu
 170                 175                 180                 185

 tca tct ggc tat ttt att aga gag cta ggt ttt gag tgg tcg ttt cta     1107
 Ser Ser Gly Tyr Phe Ile Arg Glu Leu Gly Phe Glu Trp Ser Phe Leu
                 190                 195                 200

 att att gct gtg tct ctt gct gtt aat ttg atc tat att tta ttt ttt     1155
 Ile Ile Ala Val Ser Leu Ala Val Asn Leu Ile Tyr Ile Leu Phe Phe
             205                 210                 215

 ctc gga gat cca gtg aaa gag tgt tca tct cag aat gtt act atg tca     1203
 Leu Gly Asp Pro Val Lys Glu Cys Ser Ser Gln Asn Val Thr Met Ser
         220                 225                 230

 tgt agt gaa ggc ttc aaa aac cta ttt tac cga act tac atg ctt ttt     1251
 Cys Ser Glu Gly Phe Lys Asn Leu Phe Tyr Arg Thr Tyr Met Leu Phe
     235                 240                 245

 aag aat gct tct ggt aag aga cga ttt ttg ctc tgt ttg tta ctt ttt     1299
 Lys Asn Ala Ser Gly Lys Arg Arg Phe Leu Leu Cys Leu Leu Leu Phe
 250                 255                 260                 265

 aca gta atc act tat ttt ttt gtg gta att ggc att gcc cca att ttt     1347
 Thr Val Ile Thr Tyr Phe Phe Val Val Ile Gly Ile Ala Pro Ile Phe
                 270                 275                 280

 atc ctt tat gaa ttg gat tca cca ctc tgc tgg aat gaa gtt ttt ata     1395
 Ile Leu Tyr Glu Leu Asp Ser Pro Leu Cys Trp Asn Glu Val Phe Ile
             285                 290                 295

 ggt tat gga tca gct ttg ggt agt gcc tct ttt ttg act agt ttc cta     1443
 Gly Tyr Gly Ser Ala Leu Gly Ser Ala Ser Phe Leu Thr Ser Phe Leu
         300                 305                 310

 gga ata tgg ctt ttt tct tat tgt atg gaa gat att cat atg gcc ttc     1491
 Gly Ile Trp Leu Phe Ser Tyr Cys Met Glu Asp Ile His Met Ala Phe
     315                 320                 325

 att ggg att ttt acc acg atg aca gga atg gct atg acc gcg ttt gcc     1539
 Ile Gly Ile Phe Thr Thr Met Thr Gly Met Ala Met Thr Ala Phe Ala
 330                 335                 340                 345

 agt aca aca ctg atg atg ttt tta gcc agg gtg ccg ttc ctt ttc act     1587
 Ser Thr Thr Leu Met Met Phe Leu Ala Arg Val Pro Phe Leu Phe Thr
                 350                 355                 360

 att gtg cca ttc tct gtt cta cgg tcc atg ttg tca aaa gtg gtt cgt     1635
 Ile Val Pro Phe Ser Val Leu Arg Ser Met Leu Ser Lys Val Val Arg
             365                 370                 375

 tcg act gaa caa ggt acc ctg ttt gct tgt att gct ttc tta gaa aca     1683
 Ser Thr Glu Gln Gly Thr Leu Phe Ala Cys Ile Ala Phe Leu Glu Thr
         380                 385                 390

 ctt gga gga gtc act gca gtt tct act ttt aat gga att tac tca gcc     1731
 Leu Gly Gly Val Thr Ala Val Ser Thr Phe Asn Gly Ile Tyr Ser Ala
     395                 400                 405

 act gtt gct tgg tac cct ggc ttc act ttc ctg ctg tct gct ggt ctg     1779
 Thr Val Ala Trp Tyr Pro Gly Phe Thr Phe Leu Leu Ser Ala Gly Leu
 410                 415                 420                 425

 tta cta ctt cca gcc atc agt cta tgt gtt gtc aag tgt acc agc tgg     1827
 Leu Leu Leu Pro Ala Ile Ser Leu Cys Val Val Lys Cys Thr Ser Trp
                 430                 435                 440

 aat gag gga agc tat gaa ctt ctt ata caa gaa gaa tcc agt gaa gat     1875
 Asn Glu Gly Ser Tyr Glu Leu Leu Ile Gln Glu Glu Ser Ser Glu Asp
             445                 450                 455

 gct tca gac agg tga ctgtgattta aacaaacaaa aaaaatctat gaatgcacat     1930
 Ala Ser Asp Arg 
         460

 atcatatacc atgacttctg aagactataa atgaattcca caatcagtgc ttcactgaga   1990

 accaatttta cctatctttt cttctaaact gaacagtcag agagacagct cctggcttta   2050

 gcttcttgtg gtaccacgca ctttgagcac tttgtgcgta tcatgcaata tacttgcaat   2110

 acacagaaca aatttcaaat acgcctcact tttagactta gaagagaaac attaaaactt   2170

 aagggtgtaa ggaggggatc cacgaaacct tgataaggtc cacagcatac tctctcttac   2230

 atattcccag gctcttacat gaaaacccaa gagaaaatct ttaccttcag ttcttatcca   2290

 gccgaatggg ttcttgacct ccctcaggat agtttgaacg ctatgaaact tgtgatgacc   2350

 cgcctggagc gaacgtacga ctcacgtcac aatcgtgtgc tccccctact ggaacgccgc   2410

 taacaacccg gaacgcatta cgcactgaca tatcaccgga gaccggagct cactctacca   2470

 cacgcccgcg aaacccacgg gcgtcatata tctacctatc ttcgccgcgc caacatcacc   2530

 gcccacgcaa tcccca                                                   2546




      <210> 636
      <211> 430
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(276)

      <400> 636
 ttttttataa tgccaacttt gtacaagaaa gcaggctccg cgcgcgcccc cttcacc        57                                                                 
 atg aag att tta ttt gta gaa cct gcc att ttc ctt agt gca ttt act      105
 Met Lys Ile Leu Phe Val Glu Pro Ala Ile Phe Leu Ser Ala Phe Thr
   1               5                  10                  15

 atg act ttg acc ggt cca ctg aca acg caa tat gtt tat cgg aga ata      153
 Met Thr Leu Thr Gly Pro Leu Thr Thr Gln Tyr Val Tyr Arg Arg Ile
              20                  25                  30

 tgg gaa gaa act ggc aac tac act ttt tca tct gat agc aat att tct      201
 Trp Glu Glu Thr Gly Asn Tyr Thr Phe Ser Ser Asp Ser Asn Ile Ser
          35                  40                  45

 gag tgt gaa aaa aac aaa agc agc cca att ttc gca ttc cag gag gta      249
 Glu Cys Glu Lys Asn Lys Ser Ser Pro Ile Phe Ala Phe Gln Glu Val
      50                  55                  60

 aga aat tac aat atc cat agt att taa taaaa tgggaatgta taccgtgctt      301
 Arg Asn Tyr Asn Ile His Ser Ile 
  65                  70

 tgagtcaaag aggaccgtga actcatcatc cattggtctc tctagggcgg ccatctacaa    361

 acctaaatcc caaaccaagg gggggcgcgc cgacccagct ttcttgtaca aagttggcat    421

 tataagaaa                                                            430




      <210> 637
      <211> 3026
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (15)..(2000)

      <400> 637
 agcggtggac ttga  atg gaa gga gcc cga gcc cgc gga gcg cag ctg aga      50
                  Met Glu Gly Ala Arg Ala Arg Gly Ala Gln Leu Arg
                    1               5                  10

 ctg ggg gag cgc gtt cgg cct gtg ggg cgc cgc tcg gcg ccg ggg cgc       98
 Leu Gly Glu Arg Val Arg Pro Val Gly Arg Arg Ser Ala Pro Gly Arg
          15                  20                  25

 agc agg ttc cat cag ccc tgg cgc cca ggc gca tct gac tcg gca ccc      146
 Ser Arg Phe His Gln Pro Trp Arg Pro Gly Ala Ser Asp Ser Ala Pro
      30                  35                  40

 cct gca ggc acc atg gcc cag agc cgg gtg ctg ctg ctc ctg ctg ctg      194
 Pro Ala Gly Thr Met Ala Gln Ser Arg Val Leu Leu Leu Leu Leu Leu
  45                  50                  55                  60

 ctg ccg cca cag ctg cac ctg gga cct gtg ctt gcc gtg agg gcc cca      242
 Leu Pro Pro Gln Leu His Leu Gly Pro Val Leu Ala Val Arg Ala Pro
                  65                  70                  75

 gga ttt ggc cga agt ggc ggc cac agc ctg agc ccc gaa gag aac gaa      290
 Gly Phe Gly Arg Ser Gly Gly His Ser Leu Ser Pro Glu Glu Asn Glu
              80                  85                  90

 ttt gcg gag gag gag ccg gtg ctg gta ctg agc cct gag gag ccc ggg      338
 Phe Ala Glu Glu Glu Pro Val Leu Val Leu Ser Pro Glu Glu Pro Gly
          95                 100                 105

 cct ggc cca gcc gcg gtc agc tgc ccc cga gac tgt gcc tgt tcc cag      386
 Pro Gly Pro Ala Ala Val Ser Cys Pro Arg Asp Cys Ala Cys Ser Gln
     110                 115                 120

 gag ggc gtc gtg gac tgt ggc ggt att gac ctg cgt gag ttc ccg ggg      434
 Glu Gly Val Val Asp Cys Gly Gly Ile Asp Leu Arg Glu Phe Pro Gly
 125                 130                 135                 140

 gac ctg cct gag cac acc aac cac cta tct ctg cag aac aac cag ctg      482
 Asp Leu Pro Glu His Thr Asn His Leu Ser Leu Gln Asn Asn Gln Leu
                 145                 150                 155

 gaa aag atc tac cct gag gag ctc tcc cgg ctg cac cgg ctg gag aca      530
 Glu Lys Ile Tyr Pro Glu Glu Leu Ser Arg Leu His Arg Leu Glu Thr
             160                 165                 170

 ctg aac ctg caa aac aac cgc ctg act tcc cga ggg ctc cca gag aag      578
 Leu Asn Leu Gln Asn Asn Arg Leu Thr Ser Arg Gly Leu Pro Glu Lys
         175                 180                 185

 gcg ttt gag cat ctg acc aac ctc aat tac ctg tac ttg gcc aat aac      626
 Ala Phe Glu His Leu Thr Asn Leu Asn Tyr Leu Tyr Leu Ala Asn Asn
     190                 195                 200

 aag ctg acc ttg gca ccc cgc ttc ctg cca aac gcc ctg atc agt gtg      674
 Lys Leu Thr Leu Ala Pro Arg Phe Leu Pro Asn Ala Leu Ile Ser Val
 205                 210                 215                 220

 gac ttt gct gcc aac tat ctc acc aag atc tat ggg ctc acc ttt ggc      722
 Asp Phe Ala Ala Asn Tyr Leu Thr Lys Ile Tyr Gly Leu Thr Phe Gly
                 225                 230                 235

 cag aag cca aac ttg agg tct gtg tac ctg cac aac aac aag ctg gca      770
 Gln Lys Pro Asn Leu Arg Ser Val Tyr Leu His Asn Asn Lys Leu Ala
             240                 245                 250

 gac gcc ggg ctg ccg gac aac atg ttc aac ggc tcc agc aac gtc gag      818
 Asp Ala Gly Leu Pro Asp Asn Met Phe Asn Gly Ser Ser Asn Val Glu
         255                 260                 265

 gtc ctc atc ctg tcc agc aac ttc ctg cgc cac gtg ccc aag cac ctg      866
 Val Leu Ile Leu Ser Ser Asn Phe Leu Arg His Val Pro Lys His Leu
     270                 275                 280

 ccg cct gcc ctg tac aag ctg cac ctc aag aac aac aag ctg gag aag      914
 Pro Pro Ala Leu Tyr Lys Leu His Leu Lys Asn Asn Lys Leu Glu Lys
 285                 290                 295                 300

 atc ccc ccg ggg gcc ttc agc gag ctg agc agc ctg cgc gag cta tac      962
 Ile Pro Pro Gly Ala Phe Ser Glu Leu Ser Ser Leu Arg Glu Leu Tyr
                 305                 310                 315

 ctg cag aac aac tac ctg act gac gag ggc ctg gac aac gag acc ttc     1010
 Leu Gln Asn Asn Tyr Leu Thr Asp Glu Gly Leu Asp Asn Glu Thr Phe
             320                 325                 330

 tgg aag ctc tcc agc ctg gag tac ctg gat ctg tcc agc aac aac ctg     1058
 Trp Lys Leu Ser Ser Leu Glu Tyr Leu Asp Leu Ser Ser Asn Asn Leu
         335                 340                 345

 tct cgg gtc cca gct ggg ctg ccg cgc agc ctg gtg ctg ctg cac ttg     1106
 Ser Arg Val Pro Ala Gly Leu Pro Arg Ser Leu Val Leu Leu His Leu
     350                 355                 360

 gag aag aac gcc atc cgg agc gtg gac gcg aat gtg ctg acc ccc atc     1154
 Glu Lys Asn Ala Ile Arg Ser Val Asp Ala Asn Val Leu Thr Pro Ile
 365                 370                 375                 380

 cgc agc ctg gag tac ctg ctg ctg cac agc aac cag ctg cgg gag cag     1202
 Arg Ser Leu Glu Tyr Leu Leu Leu His Ser Asn Gln Leu Arg Glu Gln
                 385                 390                 395

 ggc atc cac cca ctg gcc ttc cag ggc ctc aag cgg ttg cac acg gtg     1250
 Gly Ile His Pro Leu Ala Phe Gln Gly Leu Lys Arg Leu His Thr Val
             400                 405                 410

 cac ctg tac aac aac gcg ctg gag cgc gtg ccc agt ggc ctg cct cgc     1298
 His Leu Tyr Asn Asn Ala Leu Glu Arg Val Pro Ser Gly Leu Pro Arg
         415                 420                 425

 cgc gtg cgc acc ctc atg atc ctg cac aac cag atc aca ggc att ggc     1346
 Arg Val Arg Thr Leu Met Ile Leu His Asn Gln Ile Thr Gly Ile Gly
     430                 435                 440

 cgc gaa gac ttt gcc acc acc tac ttc ctg gag gag ctc aac ctc agc     1394
 Arg Glu Asp Phe Ala Thr Thr Tyr Phe Leu Glu Glu Leu Asn Leu Ser
 445                 450                 455                 460

 tac aac cgc atc acc agc cca cag gtg cac cgc gac gcc ttc cgc aag     1442
 Tyr Asn Arg Ile Thr Ser Pro Gln Val His Arg Asp Ala Phe Arg Lys
                 465                 470                 475

 ctg cgc ctg ctg cgc tcg ctg gac ctg tcg ggc aac cgg ctg cac acg     1490
 Leu Arg Leu Leu Arg Ser Leu Asp Leu Ser Gly Asn Arg Leu His Thr
             480                 485                 490

 ctg cca cct ggg ctg cct cga aat gtc cat gtg ctg aag gtc aag cgc     1538
 Leu Pro Pro Gly Leu Pro Arg Asn Val His Val Leu Lys Val Lys Arg
         495                 500                 505

 aat gag ctg gct gcc ttg gca cga ggg gcg ctg gcg ggc atg gct cag     1586
 Asn Glu Leu Ala Ala Leu Ala Arg Gly Ala Leu Ala Gly Met Ala Gln
     510                 515                 520

 ctg cgt gag ctg tac ctc acc agc aac cga ctg cgc agc cga gcc ctg     1634
 Leu Arg Glu Leu Tyr Leu Thr Ser Asn Arg Leu Arg Ser Arg Ala Leu
 525                 530                 535                 540

 ggc ccc cgt gcc tgg gtg gac ctc gcc cat ctg cag ctg ctg gac atc     1682
 Gly Pro Arg Ala Trp Val Asp Leu Ala His Leu Gln Leu Leu Asp Ile
                 545                 550                 555

 gcc ggg aat cag ctc aca gag atc ccc gag ggg ctc ccc gag tca ctt     1730
 Ala Gly Asn Gln Leu Thr Glu Ile Pro Glu Gly Leu Pro Glu Ser Leu
             560                 565                 570

 gag tac ctg tac ctg cag aac aac aag att agt gcg gtg ccc gcc aat     1778
 Glu Tyr Leu Tyr Leu Gln Asn Asn Lys Ile Ser Ala Val Pro Ala Asn
         575                 580                 585

 gcc ttc gac tcc acg ccc aac ctc aag ggg atc ttt ctc agg ttt aac     1826
 Ala Phe Asp Ser Thr Pro Asn Leu Lys Gly Ile Phe Leu Arg Phe Asn
     590                 595                 600

 aag ctg gct gtg ggc tcc gtg gtg gac agt gcc ttc cgg agg ctg aag     1874
 Lys Leu Ala Val Gly Ser Val Val Asp Ser Ala Phe Arg Arg Leu Lys
 605                 610                 615                 620

 cac ctg cag gtc ttg gac att gaa ggc aac tta gag ttt ggt gac att     1922
 His Leu Gln Val Leu Asp Ile Glu Gly Asn Leu Glu Phe Gly Asp Ile
                 625                 630                 635

 tcc aag gac cgt ggc cgc ttg ggg aag gaa aag gag gag gag gaa gag     1970
 Ser Lys Asp Arg Gly Arg Leu Gly Lys Glu Lys Glu Glu Glu Glu Glu
             640                 645                 650

 gag gag gag gag gaa gag gaa aca aga tag t gacaaggtga tgcagatgtg     2021
 Glu Glu Glu Glu Glu Glu Glu Thr Arg 
         655                 660

 acctaggatg atggaccgcc ggactctttt ctgcagcaca cgcctgtgtg ctgtgagccc   2081

 cccactctgc cgtgctcaca cagacacacc cagctgcaca catgaggcat cccacatgac   2141

 acgggctgac acagtctcat atccccaccc cttcccacgg cgtgtcccac ggccagacac   2201

 atgcacacac atcacaccct caaacaccca gctcagccac acacaactac cctccaaacc   2261

 accacagtct ctgtcacacc cccactaccg ctgccacgcc ctctgaatca tgcagggaag   2321

 ggtctgcccc tgccctggca cacacaggca cccattccct ccccctgctg acatgtgtat   2381

 gcgtatgcat acacaccaca cacacacaca tgcacaagtc atgtgcgaac agccctccaa   2441

 agcctatgcc acagacagct cttgccccag ccagaatcag ccatagcagc tcgccgtctg   2501

 ccctgtccat ctgtccgtcc gttccctgga gaagacacaa gggtatccat gctctgtggc   2561

 caggtgcctg ccaccctctg gaactcacaa aagctggctt ttattccttt cccatcctat   2621

 ggggacagga gccttcagga ctgctggcct ggcctggccc accctgctcc tccaggtgct   2681

 gggcagtcac tctgctaaga gtccctccct gccacgccct ggcaggacac aggcactttt   2741

 ccaatgggca agcccagtgg aggcaggatg ggagagcccc ctgggtgctg ctggggcctt   2801

 ggggcaggag tgaagcagag gtgatggggc tgggctgagc cagggaggaa ggacccagct   2861

 gcacctagga gacacctttg ttcttcaggc ctgtggggga agttccgggt gcctttattt   2921

 tttattcttt tctaaggaaa aaaatgataa aaatctcaaa gctgattttt cttgttatag   2981

 aaaaactaat ataaaagcat tatccctatc cctgcaaaaa aaaaa                   3026




      <210> 638
      <211> 1372
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1191)

      <400> 638
  atg ctg ccc ctg ctg ctg ctg ccc ctg ctg tgg ggg ggg tcc ctg cag      48
  Met Leu Pro Leu Leu Leu Leu Pro Leu Leu Trp Gly Gly Ser Leu Gln
    1               5                  10                  15

 gag aag cca gtg tac gag ctg caa gtg cag aag tcg gtg acg gtg cag       96
 Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln
              20                  25                  30

 gag ggc ctg tgc gtc ctt gtg ccc tgc tcc ttc tct tac ccc tgg aga      144
 Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg
          35                  40                  45

 tcc tgg tat tcc tct ccc cca ctc tac gtc tac tgg ttc cgg gac ggg      192
 Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly
      50                  55                  60

 gag atc cca tac tac gct gag gtt gtg gcc aca aac aac cca gac aga      240
 Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg
  65                  70                  75                  80

 aga gtg aag cca gag acc cag ggc cga ttc cgc ctc ctt ggg gat gtc      288
 Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val
                  85                  90                  95

 cag aag aag aac tgc tcc ctg agc atc gga gat gcc aga atg gag gac      336
 Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp
             100                 105                 110

 acg gga agc tat ttc ttc cgc gtg gag aga gga agg gat gta aaa tat      384
 Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr
         115                 120                 125

 agc tac caa cag aat aag ctg aac ttg gag gtg aca gcc ctg ata gag      432
 Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu
     130                 135                 140

 aaa ccc gac atc cac ttt ctg gag cct ctg gag tcc ggc cgc ccc aca      480
 Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr
 145                 150                 155                 160

 agg ctg agc tgc agc ctt cca gga tcc tgt gaa gcg gga cca cct ctc      528
 Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu
                 165                 170                 175

 aca ttc tcc tgg acg ggg aat gcc ctc agc ccc ctg gac ccc gag acc      576
 Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr
             180                 185                 190

 acc cgc tcc tcg gag ctc acc ctc acc ccc agg ccc gag gac cat ggc      624
 Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly
         195                 200                 205

 acc aac ctc acc tgt cag gtg aaa cgc caa gga gct cag gtg acc acg      672
 Thr Asn Leu Thr Cys Gln Val Lys Arg Gln Gly Ala Gln Val Thr Thr
     210                 215                 220

 gag aga act gtc cag ctc aat gtc tcc tat gct cca cag aac ctc gcc      720
 Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Asn Leu Ala
 225                 230                 235                 240

 atc agc atc ttc ttc aga aat ggc aca ggc aca gcc ctg cgg atc ctg      768
 Ile Ser Ile Phe Phe Arg Asn Gly Thr Gly Thr Ala Leu Arg Ile Leu
                 245                 250                 255

 agc aat ggc atg tcg gtg ccc atc cag gag ggc cag tcc ctg ttc ctc      816
 Ser Asn Gly Met Ser Val Pro Ile Gln Glu Gly Gln Ser Leu Phe Leu
             260                 265                 270

 gcc tgc aca gtt gac agc aac ccc cct gcc tca ctg agc tgg ttc cgg      864
 Ala Cys Thr Val Asp Ser Asn Pro Pro Ala Ser Leu Ser Trp Phe Arg
         275                 280                 285

 gag gga aaa gcc ctc aat cct tcc cag acc tca atg tct ggg acc ctg      912
 Glu Gly Lys Ala Leu Asn Pro Ser Gln Thr Ser Met Ser Gly Thr Leu
     290                 295                 300

 gag ctg cct aac ata gga gct aga gag gga ggg gaa ttc acc tgc cgg      960
 Glu Leu Pro Asn Ile Gly Ala Arg Glu Gly Gly Glu Phe Thr Cys Arg
 305                 310                 315                 320

 gtt cag cat ccg ctg ggc tcc cag cac ctg tcc ttc atc ctt tct gtg     1008
 Val Gln His Pro Leu Gly Ser Gln His Leu Ser Phe Ile Leu Ser Val
                 325                 330                 335

 cag aga agc tcc tct tcc tgc ata tgt gta act gag aaa cag cag ggc     1056
 Gln Arg Ser Ser Ser Ser Cys Ile Cys Val Thr Glu Lys Gln Gln Gly
             340                 345                 350

 tcc tgg ccc ctc gtc ctc acc ctg atc agg ggg gct ctc atg ggg gct     1104
 Ser Trp Pro Leu Val Leu Thr Leu Ile Arg Gly Ala Leu Met Gly Ala
         355                 360                 365

 ggc ttc ctc ctc acc tat ggc ctc acc tgg atc tac tat acc agg tgt     1152
 Gly Phe Leu Leu Thr Tyr Gly Leu Thr Trp Ile Tyr Tyr Thr Arg Cys
     370                 375                 380

 gga ggc ccc cag cag agc agg gct gag agg cct ggc tga gcccctcccg      1201
 Gly Gly Pro Gln Gln Ser Arg Ala Glu Arg Pro Gly 
 385                 390                 395

 ctcaagacag aactgaggtg tggacactta gccctgtggg acacatgcag gacatcactg   1261

 tcagcttctt tctggaagct cacatcccac tgactacccc tcttttcctt cctgccccat   1321

 accccttcta cttattcccc tctgcttgtg agtcttgccc caccatgtat t            1372




      <210> 639
      <211> 1928
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(942)

      <400> 639
  atg ctg ccc ctg ctg ctg ctg ccc ctg ctg tgg ggg ggg tcc ctg cag      48
  Met Leu Pro Leu Leu Leu Leu Pro Leu Leu Trp Gly Gly Ser Leu Gln
    1               5                  10                  15

 gag aag cca gtg tac gag ctg caa gtg cag aag tcg gtg acg gtg cag       96
 Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln
              20                  25                  30

 gag ggc ctg tgc gtc ctt gtg ccc tgc tcc ttc tct tac ccc tgg aga      144
 Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg
          35                  40                  45

 tcc tgg tat tcc tct ccc cca ctc tac gtc tac tgg ttc cgg gac ggg      192
 Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly
      50                  55                  60

 gag atc cca tac tac gct gag gtt gtg gcc aca aac aac cca gaa aga      240
 Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Glu Arg
  65                  70                  75                  80

 aga gtg aag cca ggg acc cag ggc cga ttc cgc ctc ctt ggg gat gtc      288
 Arg Val Lys Pro Gly Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val
                  85                  90                  95

 cag aag aag aac tgc tcc ctg agc atc gga gat gcc aga atg gag gac      336
 Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp
             100                 105                 110

 acg gga agc tat ttc ttc cgc gtg gag aga gga agg gat gta aaa tat      384
 Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr
         115                 120                 125

 agc tac caa cag aat aag ctg aac ttg gag gtg aca gtc ctg ata gag      432
 Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Val Leu Ile Glu
     130                 135                 140

 aaa ccc gac atc cac ttt ctg gag cct ctg gag tcc ggc cgc ccc aca      480
 Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr
 145                 150                 155                 160

 agg ctg agc tgc agc ctt cca gga tcc tgt gaa gcg gga cca cct ctc      528
 Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu
                 165                 170                 175

 aca ttc tcc tgg acg ggg aat gcc ctc agc ccc ctg gac ccc gag acc      576
 Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr
             180                 185                 190

 acc cgc tcc tcg gag ctc acc ctc acc ccc agg ccc gag gac cat ggc      624
 Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly
         195                 200                 205

 acc aac ctc acc tgt cag gtg aaa cgc caa gga gct cag gtg acc acg      672
 Thr Asn Leu Thr Cys Gln Val Lys Arg Gln Gly Ala Gln Val Thr Thr
     210                 215                 220

 gag aga act gtc cag ctc aat gtc tcc tat gct cca cag aac ctc gcc      720
 Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Asn Leu Ala
 225                 230                 235                 240

 atc agc atc ttc ttc aga aat ggc aca ggc aca gcc ctg cgg atc ctg      768
 Ile Ser Ile Phe Phe Arg Asn Gly Thr Gly Thr Ala Leu Arg Ile Leu
                 245                 250                 255

 agc aat ggc atg tcg gtg ccc atc cag gag ggc cag tcc ctg ttc ctc      816
 Ser Asn Gly Met Ser Val Pro Ile Gln Glu Gly Gln Ser Leu Phe Leu
             260                 265                 270

 gcc tgc aca gtt gac agc aac ccc cct gcc tca ctg agc tgg ttc cgg      864
 Ala Cys Thr Val Asp Ser Asn Pro Pro Ala Ser Leu Ser Trp Phe Arg
         275                 280                 285

 gag gga aaa gcc ctc aat cct tcc cag acc tca atg tcc cgg gtc gac      912
 Glu Gly Lys Ala Leu Asn Pro Ser Gln Thr Ser Met Ser Arg Val Asp
     290                 295                 300

 gat ttc gtg agg aag gga tgt aaa ata tag c taccaacaga ataagctgaa      963
 Asp Phe Val Arg Lys Gly Cys Lys Ile 
 305                 310

 cttggaggtg acagccctga tagagaaacc cgacatccac tttctggagc ctctggagtc   1023

 cggccgcccc acaaggctga gctgcagcct tccaggatcc tgtgaagcgg gaccacctct   1083

 cacattctcc tggacgggga atgccctcag ccccctggac cccgagacca cccgctcctc   1143

 ggagctcacc ctcaccccca ggcccgagga ccatggcacc aacctcacct gtcaggtgaa   1203

 acgccaagga gctcaggtga ccacggagag aactgtccag ctcaatgtct cctatgctcc   1263

 acagaacctc gccatcagca tcttcttcag aaatggcaca ggcacagccc tgcggatcct   1323

 gagcaatggc atgtcggtgc ccatccagga gggccagtcc ctgttcctcg cctgcacagt   1383

 tgacagcaac ccccctgcct cactgagctg gttccgggag ggaaaagccc tcaatccttc   1443

 ccagacctca atgtctggga ccctggagct gcctaacata ggagctagag agggagggga   1503

 attcacctgc cgggttcagc atccgctggg ctcccagcac ctgtccttca tcctttctgt   1563

 gcagagaagc tcctcttcct gcatatgtgt aactgagaaa cagcagggct cctggcccct   1623

 cgtcctcacc ctgatcaggg gggctctcat gggggctggc ttcctcctca cctatggcct   1683

 cacctggatc tactatacca ggtgtggagg cccccagcag agcagggctg agaggcctgg   1743

 ctgagcccct cccgctcaag acagaactga ggtgtggaca cttagccctg tgggacacat   1803

 gcaggacatc actgtcagct tctttctgga agctcacatc ccactgacta cccctctttt   1863

 ccttcctgcc ccatacccct tctacttatt cccctctgct tgtgagtctt gccccaccat   1923

 gtatt                                                               1928




      <210> 640
      <211> 863
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(674)

      <400> 640
 tcccgggtcg acgatttcgt ctggagtgtt agcaccagta ctggatgtga cattaggcat     60

 aggagcactt agcagcttat tcagtggccg attctgattc cggcaaggat ccaagc        116                                                                 
 atg gaa tgc tgc cgt cgg gca act cct ggc aca ctg ctc ctc ttt ctg      164
 Met Glu Cys Cys Arg Arg Ala Thr Pro Gly Thr Leu Leu Leu Phe Leu
   1               5                  10                  15

 gct ttc ctg ctc ctg agt tcc agg acc gca cgc tcc gag gag gac cgg      212
 Ala Phe Leu Leu Leu Ser Ser Arg Thr Ala Arg Ser Glu Glu Asp Arg
              20                  25                  30

 gac ggc cta tgg gat gcc tgg ggc cca tgg agt gaa tgc tca cgc acc      260
 Asp Gly Leu Trp Asp Ala Trp Gly Pro Trp Ser Glu Cys Ser Arg Thr
          35                  40                  45

 tgc ggg gga ggg gcc tcc tac tct ctg agg cgc tgc ctg agc agc aag      308
 Cys Gly Gly Gly Ala Ser Tyr Ser Leu Arg Arg Cys Leu Ser Ser Lys
      50                  55                  60

 agc tgt gaa gga aga aat atc cga tac aga aca tgc agt aat gtg gac      356
 Ser Cys Glu Gly Arg Asn Ile Arg Tyr Arg Thr Cys Ser Asn Val Asp
  65                  70                  75                  80

 tgc cca cca gaa gca ggt gat ttc cga gct cag caa tgc tca gct cat      404
 Cys Pro Pro Glu Ala Gly Asp Phe Arg Ala Gln Gln Cys Ser Ala His
                  85                  90                  95

 aat gat gtc aag cac cat ggc cag ttt tat gaa tgg ctt cct gtg tct      452
 Asn Asp Val Lys His His Gly Gln Phe Tyr Glu Trp Leu Pro Val Ser
             100                 105                 110

 aat gac cct gac aac cca tgt tca ctc aag tgc caa gcc aaa gga aca      500
 Asn Asp Pro Asp Asn Pro Cys Ser Leu Lys Cys Gln Ala Lys Gly Thr
         115                 120                 125

 acc ctg gtt gtt gaa cta gca cct aag gtc tta gat ggt acg cgt tgc      548
 Thr Leu Val Val Glu Leu Ala Pro Lys Val Leu Asp Gly Thr Arg Cys
     130                 135                 140

 tat aca gaa tct ttg gat atg tgc atc agt ggt tta tgc caa gta agt      596
 Tyr Thr Glu Ser Leu Asp Met Cys Ile Ser Gly Leu Cys Gln Val Ser
 145                 150                 155                 160

 gct gat ttg ttc tca ttc aac ttg tcc aga ggg ttt caa tgt ctt tgt      644
 Ala Asp Leu Phe Ser Phe Asn Leu Ser Arg Gly Phe Gln Cys Leu Cys
                 165                 170                 175

 gta aat ggt tta cat agt ctc act ctc tga a tcactcatct ttacactttt      695
 Val Asn Gly Leu His Ser Leu Thr Leu 
             180                 185

 tagagtttgt aaatggtgaa agatttgaaa attaaggtat gatttcagtg aaaagtacca    755

 agtgttgtat tgtgcgaagg aaaagtagac tagagttatt tttctttcct tgagtgtcac    815

 ttgaatataa aagaataaaa atttttgaat agtgttaaaa aaaaaaaa                 863




      <210> 641
      <211> 598
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(326)

      <400> 641
 ccagagtctg ggctctgtac act    atg ggc aca caa ctc ctc cca gct ctg      50
                              Met Gly Thr Gln Leu Leu Pro Ala Leu
                                1               5

 tgt ctt gtg ctc ctg gta ttg gga ttt gag gtc cag ggg acc caa cag       98
 Cys Leu Val Leu Leu Val Leu Gly Phe Glu Val Gln Gly Thr Gln Gln
  10                  15                  20                  25

 ccc cag caa gat gag atg cct agc ccg acc ttt ctc acc caa gtg aag      146
 Pro Gln Gln Asp Glu Met Pro Ser Pro Thr Phe Leu Thr Gln Val Lys
                  30                  35                  40

 gaa tct ctc tcc agt tac tgg gag tca gca aag aca gcc gcc cag aac      194
 Glu Ser Leu Ser Ser Tyr Trp Glu Ser Ala Lys Thr Ala Ala Gln Asn
              45                  50                  55

 ctg tgc gag aag aca tac ctg tcc gct gga gat gag aaa ctc agg gac      242
 Leu Cys Glu Lys Thr Tyr Leu Ser Ala Gly Asp Glu Lys Leu Arg Asp
          60                  65                  70

 tct ggc agc ggc aca gct gcc atg agc act tac aca ggc ctt ttt act      290
 Ser Gly Ser Gly Thr Ala Ala Met Ser Thr Tyr Thr Gly Leu Phe Thr
      75                  80                  85

 ggc caa gtt ctt tct gtg ctg aag gga gag gag taa cagc cagacccccc      340
 Gly Gln Val Leu Ser Val Leu Lys Gly Glu Glu 
  90                  95                 100

 atcagtggac aaggggagag tcccctactc ccctgatccc ccaggttcag actgagctcc    400

 cccttcccag tagctcttgc atcctcctcc caactctagc ctgaattctt ttcaataaaa    460

 aatacaattc aagttgcttc tcatggatgg cactgctttt ctgaggactc aagggccaag    520

 atggaggggc tgactcagtc cagccaacat ttaatgagca cctactttat gtatggagct    580

 ctaacccatg ggtccact                                                  598




      <210> 642
      <211> 395
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(374)

      <400> 642
 ccagagtctg ggctctgtac act    atg ggc aca caa ctc ctc cca gct ctg      50
                              Met Gly Thr Gln Leu Leu Pro Ala Leu
                                1               5

 tgt ctt gtg ctc ctg gta ttg gga ttt gag gtc cag ggg acc caa cag       98
 Cys Leu Val Leu Leu Val Leu Gly Phe Glu Val Gln Gly Thr Gln Gln
  10                  15                  20                  25

 ccc cag caa gat gag atg cct agc ccg acc ttt ctc acc caa gtg aag      146
 Pro Gln Gln Asp Glu Met Pro Ser Pro Thr Phe Leu Thr Gln Val Lys
                  30                  35                  40

 gaa tct ctc tcc agt tac tgg gag tca gca aag aca gcc gcc cag aac      194
 Glu Ser Leu Ser Ser Tyr Trp Glu Ser Ala Lys Thr Ala Ala Gln Asn
              45                  50                  55

 ctg tgc gag aag aca tac ctg tcc gct gga gat gag aaa ctc agg gac      242
 Leu Cys Glu Lys Thr Tyr Leu Ser Ala Gly Asp Glu Lys Leu Arg Asp
          60                  65                  70

 tct ggc agc ggc aca gct gcc atg agc act tac aca ggc ctt ttt act      290
 Ser Gly Ser Gly Thr Ala Ala Met Ser Thr Tyr Thr Gly Leu Phe Thr
      75                  80                  85

 ggc caa gtt ctt tct gtg ctg aag gga gag gag tta cag gca gac ccc      338
 Gly Gln Val Leu Ser Val Leu Lys Gly Glu Glu Leu Gln Ala Asp Pro
  90                  95                 100                 105

 cca tca gtg gac ggg gag agt gcc cta ctt ccc tga gccc ccatggtcag      388
 Pro Ser Val Asp Gly Glu Ser Ala Leu Leu Pro 
                 110                 115

 actggct                                                              395




      <210> 643
      <211> 1212
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (500)..(754)

      <400> 643
 gagcagtgtg aagaagaggc gagaacgacc cccggaccga ccaaagcccg cgcgccgctg     60

 catcccgcgt ccagcaccta cgtcccgctg ccgtcgccgc cgccaccatg cccaagagaa    120

 aggctgaagg ggatgctaag ggagataaag caaaggtgaa ggacgaacca cagagaagat    180

 ccgcgaggtt gtctgctaaa cctgctcctc caaagccaga gcccaagcct aaaaaggccc    240

 ctgcaaagaa gggagagaag gtacccaaag ggaaaaaggg aaaagctgat gctggcaagg    300

 aggggaataa ccctgcagaa aatggagatg ccaaaacaga ccaggcacag aaagctgaag    360

 gtgctggaga tgccaagtga agtgtgtgca tttttgataa ctgtgtactt ctggtgactg    420

 tacagtttga aatactattt tttatcaagt tttataaaaa tgcagaattt tgttttactt    480

 tttttttttt ttaaaagct atg ttg tta gca cac aga aca ctt cat tgt tgt     532
                      Met Leu Leu Ala His Arg Thr Leu His Cys Cys
                        1               5                  10

 ttt tgg ggg aag ggg cat atg tca cta ata gaa tgt ctc caa agc tgg      580
 Phe Trp Gly Lys Gly His Met Ser Leu Ile Glu Cys Leu Gln Ser Trp
              15                  20                  25

 att gat gtg gag aaa aca cct ttc cct tct agt ttt gag aga ctt cct      628
 Ile Asp Val Glu Lys Thr Pro Phe Pro Ser Ser Phe Glu Arg Leu Pro
          30                  35                  40

 ctt ggc tcc cag gag gag gga ttc cct gac ttt gac aca cat ggc cac      676
 Leu Gly Ser Gln Glu Glu Gly Phe Pro Asp Phe Asp Thr His Gly His
      45                  50                  55

 ctt ggc aca aaa gcc ttg tgg tat aga aaa aca aat ttg ttt tta tgt      724
 Leu Gly Thr Lys Ala Leu Trp Tyr Arg Lys Thr Asn Leu Phe Leu Cys
  60                  65                  70                  75

 cct ctt ctc cct ttc cat ctt tca gca tag a cttaactccc ttaagcccag      775
 Pro Leu Leu Pro Phe His Leu Ser Ala 
                  80

 acatctgttg agacctgacc cctagtcatt ggttaccagt gtgtcaggca atctggactt    835

 tccagtgatg ccactgagat ggcacctgtc aaaagagcag tggttccatt tctagattgt    895

 ggatcttcag ataaattctg ccattttcat ttcacttcct gaaagtcagg gtcggcttgt    955

 gaaaagttgt taaacaacat gctaaatgtg aaatgtcaac cctcactcta aactttccct   1015

 gttcagagca tcagatgaag acttcattgg gttttatagt ggctttctga tttttggtag   1075

 tccattgaag aagggagttt gaaagttgtt gtatactgtt aacgattgtc tgcccatgtc   1135

 ctgcctgaaa taccatgatt gtttatggaa agtatcttta ataaagctgg atacagtttg   1195

 gcttggaaaa aaaaaaa                                                  1212




      <210> 644
      <211> 2265
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2265)

      <400> 644
  atg agg gtc ttg gcc tgc ctc ctt gag cgc ctg cgc ctg gcc gat ggc      48
  Met Arg Val Leu Ala Cys Leu Leu Glu Arg Leu Arg Leu Ala Asp Gly
    1               5                  10                  15

 ccc cat ggg tgc gct ggc cgc ctg gag gtc tgg cat ggc ggg cgc tgg       96
 Pro His Gly Cys Ala Gly Arg Leu Glu Val Trp His Gly Gly Arg Trp
              20                  25                  30

 ggc acc gtg tgt gat gac ggc tgg gac ctg cgc gat gcc gcc gtg gcc      144
 Gly Thr Val Cys Asp Asp Gly Trp Asp Leu Arg Asp Ala Ala Val Ala
          35                  40                  45

 tgc cgg cag ctg ggc tgc gga ggg gca ctg gcc gcc ccg gga ggc gcc      192
 Cys Arg Gln Leu Gly Cys Gly Gly Ala Leu Ala Ala Pro Gly Gly Ala
      50                  55                  60

 ttc ttc ggg gag ggg gca ggg cct gtg tgg ctc agc gag ctg gct tgc      240
 Phe Phe Gly Glu Gly Ala Gly Pro Val Trp Leu Ser Glu Leu Ala Cys
  65                  70                  75                  80

 cgg ggc aac gag ggg cag ctg ggc ctc tgc cac cac cgg ggc tgg aag      288
 Arg Gly Asn Glu Gly Gln Leu Gly Leu Cys His His Arg Gly Trp Lys
                  85                  90                  95

 gcc cac atc tgc tcc cac gag gag gac gcg ggc gtc gtc tgc gca ggt      336
 Ala His Ile Cys Ser His Glu Glu Asp Ala Gly Val Val Cys Ala Gly
             100                 105                 110

 cag cgt gtg gct aac tcc agg gac gac tca aca tct ccc ctg gat ggg      384
 Gln Arg Val Ala Asn Ser Arg Asp Asp Ser Thr Ser Pro Leu Asp Gly
         115                 120                 125

 gct ccc tgg cca ggg ctg ttg ctg gag ctg agc ccc agc acg gag gag      432
 Ala Pro Trp Pro Gly Leu Leu Leu Glu Leu Ser Pro Ser Thr Glu Glu
     130                 135                 140

 ccc ctg gtg aca cat gct ggg aac ccc cag aac gcc tcc cgg aag aag      480
 Pro Leu Val Thr His Ala Gly Asn Pro Gln Asn Ala Ser Arg Lys Lys
 145                 150                 155                 160

 agc ccc cgg ccc aag cag gcc aag tcc acc cgg gcc cct ctg ctg acg      528
 Ser Pro Arg Pro Lys Gln Ala Lys Ser Thr Arg Ala Pro Leu Leu Thr
                 165                 170                 175

 aca gga gcc ccc cgc caa gag cgg ctg cgc ctg gtc tct ggc ccc cac      576
 Thr Gly Ala Pro Arg Gln Glu Arg Leu Arg Leu Val Ser Gly Pro His
             180                 185                 190

 agg tgc gcc gga cgc ctg gag gtc tgg cac ggc ggg cgc tgg ggc acc      624
 Arg Cys Ala Gly Arg Leu Glu Val Trp His Gly Gly Arg Trp Gly Thr
         195                 200                 205

 gta tgt gac gat ggc tgg gac ctg cgc gac gct gct gta gcc tgc cgg      672
 Val Cys Asp Asp Gly Trp Asp Leu Arg Asp Ala Ala Val Ala Cys Arg
     210                 215                 220

 gaa ctg ggc tgt ggg ggg gcg ctg gct gcc ccc ggc ggt gcc aga ttc      720
 Glu Leu Gly Cys Gly Gly Ala Leu Ala Ala Pro Gly Gly Ala Arg Phe
 225                 230                 235                 240

 ggg cct ggt gca ggg ccc gtg tgg atg gac gat gtg ggg tgt gga gga      768
 Gly Pro Gly Ala Gly Pro Val Trp Met Asp Asp Val Gly Cys Gly Gly
                 245                 250                 255

 gga gaa cag gcc ctc cga gac tgc ccc cga agc ccc tgg ggc cgg agc      816
 Gly Glu Gln Ala Leu Arg Asp Cys Pro Arg Ser Pro Trp Gly Arg Ser
             260                 265                 270

 aac tgt gac cac agc gag gat gcg ggg ctg gtc tgc acc gat gag gaa      864
 Asn Cys Asp His Ser Glu Asp Ala Gly Leu Val Cys Thr Asp Glu Glu
         275                 280                 285

 aag cag aca ggc cca gca cct cgg ctg cgc ctg gcc gat ggc ccc cac      912
 Lys Gln Thr Gly Pro Ala Pro Arg Leu Arg Leu Ala Asp Gly Pro His
     290                 295                 300

 ggg tgc gcc ggc cgc ctg gag gtc tgg cac ggg ggt cgc tgg ggg tcg      960
 Gly Cys Ala Gly Arg Leu Glu Val Trp His Gly Gly Arg Trp Gly Ser
 305                 310                 315                 320

 gtg tgt gac gac gcc tgg gac ctg cga gac gcc gct gtg gcc tgc cga     1008
 Val Cys Asp Asp Ala Trp Asp Leu Arg Asp Ala Ala Val Ala Cys Arg
                 325                 330                 335

 gag ctg ggc tgc gga ggg gcg ctg gcc gcc ccc ggg ggc gcc ttc ttt     1056
 Glu Leu Gly Cys Gly Gly Ala Leu Ala Ala Pro Gly Gly Ala Phe Phe
             340                 345                 350

 ggg gag ggg tct gga ccc atc atc ctg gac gac ctt cgg tgt cgg gga     1104
 Gly Glu Gly Ser Gly Pro Ile Ile Leu Asp Asp Leu Arg Cys Arg Gly
         355                 360                 365

 aac gag acg gcc tta cga ttc tgc cca gct cgg ccc tgg ggc cag cat     1152
 Asn Glu Thr Ala Leu Arg Phe Cys Pro Ala Arg Pro Trp Gly Gln His
     370                 375                 380

 gac tgt cac cac cgc gag gac gcc ggg gcc gtg tgt gac ggg tcc ccc     1200
 Asp Cys His His Arg Glu Asp Ala Gly Ala Val Cys Asp Gly Ser Pro
 385                 390                 395                 400

 cag ctg cgc ctg gtg gct ggg ccc agc aag tgc tca ggt cga ctg gag     1248
 Gln Leu Arg Leu Val Ala Gly Pro Ser Lys Cys Ser Gly Arg Leu Glu
                 405                 410                 415

 gtg tgg cat gac cag cgc tgg ggg acc gtg tgt gac gat agc tgg gac     1296
 Val Trp His Asp Gln Arg Trp Gly Thr Val Cys Asp Asp Ser Trp Asp
             420                 425                 430

 atg cgg gat tca gct gtg gtc tgc cgg gag ctg ggc tgt ggt gga cct     1344
 Met Arg Asp Ser Ala Val Val Cys Arg Glu Leu Gly Cys Gly Gly Pro
         435                 440                 445

 cag cag cca gac cct gct gct ggc cgc ttt ggc tgg ggt gcg ggc ccc     1392
 Gln Gln Pro Asp Pro Ala Ala Gly Arg Phe Gly Trp Gly Ala Gly Pro
     450                 455                 460

 atc tgg cta gat gat gtg ggc tgt gtg ggg acc gag gct tca ctg tcc     1440
 Ile Trp Leu Asp Asp Val Gly Cys Val Gly Thr Glu Ala Ser Leu Ser
 465                 470                 475                 480

 gac tgc cct gct gct ccc tgg gga aag cac aac tgc gct cac aat gag     1488
 Asp Cys Pro Ala Ala Pro Trp Gly Lys His Asn Cys Ala His Asn Glu
                 485                 490                 495

 gat gtt ggg gtc acc tgc act ggg ccc cca ggc ctg gac tcc atc tca     1536
 Asp Val Gly Val Thr Cys Thr Gly Pro Pro Gly Leu Asp Ser Ile Ser
             500                 505                 510

 gac ccc ttc agc tgg agc tgg att cct gga ctg ggg aga gat cgg gat     1584
 Asp Pro Phe Ser Trp Ser Trp Ile Pro Gly Leu Gly Arg Asp Arg Asp
         515                 520                 525

 gcc tgg ctc ccg gga gag ctg gcc acc aag ccc tct gca agt gtg act     1632
 Ala Trp Leu Pro Gly Glu Leu Ala Thr Lys Pro Ser Ala Ser Val Thr
     530                 535                 540

 gcc agt gtt ctg gag aaa aca acc acg aag gcc cca ggg aaa atg cct     1680
 Ala Ser Val Leu Glu Lys Thr Thr Thr Lys Ala Pro Gly Lys Met Pro
 545                 550                 555                 560

 aag agt act aag aag tgg gcc ccc cga gaa cgg acc act aag acc atg     1728
 Lys Ser Thr Lys Lys Trp Ala Pro Arg Glu Arg Thr Thr Lys Thr Met
                 565                 570                 575

 gca atg ctg acc act caa ggc ccc caa gaa atg acc tct gag tcc act     1776
 Ala Met Leu Thr Thr Gln Gly Pro Gln Glu Met Thr Ser Glu Ser Thr
             580                 585                 590

 atc aag agt atc cct cag gcc tcc ctg gag cca tct gct gag atc cca     1824
 Ile Lys Ser Ile Pro Gln Ala Ser Leu Glu Pro Ser Ala Glu Ile Pro
         595                 600                 605

 gaa ggg tct cca gag tca ccc aaa gac ccg gcc ccc tct ccc agt gtt     1872
 Glu Gly Ser Pro Glu Ser Pro Lys Asp Pro Ala Pro Ser Pro Ser Val
     610                 615                 620

 agc acc act ggg gaa tca ggc ctg ttc cgg gtt cgt ctg gcc gat ggg     1920
 Ser Thr Thr Gly Glu Ser Gly Leu Phe Arg Val Arg Leu Ala Asp Gly
 625                 630                 635                 640

 ccc aac cgc tgt gct ggc cgg ctg gaa gtg tgg cat gcc gga cgc tgg     1968
 Pro Asn Arg Cys Ala Gly Arg Leu Glu Val Trp His Ala Gly Arg Trp
                 645                 650                 655

 gga aca gtg tgt gat gac aac tgg gac ctg cgg gac gcc act gtg gcc     2016
 Gly Thr Val Cys Asp Asp Asn Trp Asp Leu Arg Asp Ala Thr Val Ala
             660                 665                 670

 tgc tgg gaa ctg ggc tgt gga aag gtc cgg cct cga gta ggc aaa acc     2064
 Cys Trp Glu Leu Gly Cys Gly Lys Val Arg Pro Arg Val Gly Lys Thr
         675                 680                 685

 cat tac ggc cct ggg act ggg ccc atc tgg ctg gat gac atg ggc tgt     2112
 His Tyr Gly Pro Gly Thr Gly Pro Ile Trp Leu Asp Asp Met Gly Cys
     690                 695                 700

 aag gga agc gag gcc tca ctg agc gac tgc ccc tcg ggg gct tgg ggg     2160
 Lys Gly Ser Glu Ala Ser Leu Ser Asp Cys Pro Ser Gly Ala Trp Gly
 705                 710                 715                 720

 aag cac aac tgt gac cac gag gaa gac agc cgg aag cgg gag ctc cga     2208
 Lys His Asn Cys Asp His Glu Glu Asp Ser Arg Lys Arg Glu Leu Arg
                 725                 730                 735

 gag gtg atg ctc ctc gtt caa gga ctg cca ggg ttg cag cgc ctc cct     2256
 Glu Val Met Leu Leu Val Gln Gly Leu Pro Gly Leu Gln Arg Leu Pro
             740                 745                 750

 agc cca tag                                                         2265
 Ser Pro 






      <210> 645
      <211> 899
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (193)..(762)

      <400> 645
 gggtatcgac gactttcgta gctgatggat gatgagcacc cagacttcta aaaatgtatc     60

 actaccggaa ttgagataca aacagcattt aggaaggact catctgagta gcagctttct    120

 gtatagcgtg ttggagataa gtcgggcttt tggtgagaca gactttccca accctctgcc    180

 ccgccggtgc cc    atg ctt ctg tgg ctg ctg ctg ctg atc ctg act cct     228
                  Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro
                    1               5                  10

 gga aga gaa caa tca ggg gtg gcc cca aaa gct gta ctt ctc ctc gat      276
 Gly Arg Glu Gln Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asp
          15                  20                  25

 cct cca tgg tcc aca gcc ttc aaa gga gaa aaa gtg gct ctc ata tgc      324
 Pro Pro Trp Ser Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys
      30                  35                  40

 agc agc ata tca cat tcc cta gcc cag gga gac aca tat tgg tat cac      372
 Ser Ser Ile Ser His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His
  45                  50                  55                  60

 gat gag aag ttg ttg aaa ata aaa cat gac aag atc caa att aca gag      420
 Asp Glu Lys Leu Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu
                  65                  70                  75

 cct gga aat tac caa tgt aag acc cga gga tcc tcc ctc agt gat gcc      468
 Pro Gly Asn Tyr Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala
              80                  85                  90

 gtg cat gtg gaa ttt tca cct gac tgg ctg atc ctg cag gct tta cat      516
 Val His Val Glu Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His
          95                 100                 105

 cct gtt ttt gaa gga gac aat gtc att ctg aga tgt cag ggg aaa gac      564
 Pro Val Phe Glu Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp
     110                 115                 120

 aac aaa aac act cat caa aag gtt tac tac aag gat gga aaa cag ctt      612
 Asn Lys Asn Thr His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu
 125                 130                 135                 140

 cct aat agt tat aat tta gag aag atc aca gtg aat tca gtc tcc agg      660
 Pro Asn Ser Tyr Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg
                 145                 150                 155

 gat aat agc aaa tat cat tgt act gct tat agg aag ttt tac ata ctt      708
 Asp Asn Ser Lys Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu
             160                 165                 170

 gac att gaa gta act tca aaa ccc cta aat atc caa gtt caa ggt aat      756
 Asp Ile Glu Val Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Gly Asn
         175                 180                 185

 ggc tag attcctgtgg attactgggt ttgttaggga aactggggat aaagggaaga       812
 Gly 


 tgtttatcag tgggaatttc ataaagagtc tcctatggct cagccatggg agggagatgg    872

 gtccttctgc atgcttctct atctctg                                        899




      <210> 646
      <211> 1178
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (288)..(950)

      <400> 646
 gggaggtttg gggactctgt gcccactaag ctactttcta tttcaagtgc ctgtatgtct     60

 gaggctgggt ttgaagcctc cagcgtgttt ggagttaatc cccattaggt tggactccgc    120

 ccctttctcc caaaggtaaa gcaaggtttt caggcatcac tgcaaagggc agctagtatt    180

 cccatccttg tctaacaagc tgtaaggaga agttgtttct gagatctgag cctgaagaga    240

 gggaacaagt cagtcagcct tcgtggtcag aagagaaacc tgtgacc  atg agg agc     296
                                                      Met Arg Ser
                                                        1

 agc ctg acc atg gtg gga acc ctc tgg gcc ttc ctg tcc ctt gtt act      344
 Ser Leu Thr Met Val Gly Thr Leu Trp Ala Phe Leu Ser Leu Val Thr
       5                  10                  15

 gct gtg acc agt tct acc agt tac ttc cta cct tac tgg ctc ttt gga      392
 Ala Val Thr Ser Ser Thr Ser Tyr Phe Leu Pro Tyr Trp Leu Phe Gly
  20                  25                  30                  35

 tcc cag atg ggg aag cca gtg tca ttc agc aca ttc cgg agg tgc aac      440
 Ser Gln Met Gly Lys Pro Val Ser Phe Ser Thr Phe Arg Arg Cys Asn
                  40                  45                  50

 tac cct gtg cgg gga gag gga cac agt ctg atc atg gtg gaa gaa tgt      488
 Tyr Pro Val Arg Gly Glu Gly His Ser Leu Ile Met Val Glu Glu Cys
              55                  60                  65

 ggg cgc tat gcc agc ttc aat gcc atc cca agc ctg gcc tgg cag atg      536
 Gly Arg Tyr Ala Ser Phe Asn Ala Ile Pro Ser Leu Ala Trp Gln Met
          70                  75                  80

 tgc aca gtg gtg aca ggt gcc ggc tgt gct ctg ctg ctc ctg gtg gca      584
 Cys Thr Val Val Thr Gly Ala Gly Cys Ala Leu Leu Leu Leu Val Ala
      85                  90                  95

 cta gct gct gtc ctg ggt tgc tgc atg gag gag ctc atc tcc aga atg      632
 Leu Ala Ala Val Leu Gly Cys Cys Met Glu Glu Leu Ile Ser Arg Met
 100                 105                 110                 115

 atg gga cgt tgc atg gga gca gcg cag ttt gtt gga ggg ctg ctg ata      680
 Met Gly Arg Cys Met Gly Ala Ala Gln Phe Val Gly Gly Leu Leu Ile
                 120                 125                 130

 agc tca ggc tgt gcc tta tac cct tta gga tgg aat agc ccg gag ata      728
 Ser Ser Gly Cys Ala Leu Tyr Pro Leu Gly Trp Asn Ser Pro Glu Ile
             135                 140                 145

 atg caa aca tgt ggg aat gtc tcc aat caa ttt cag tta ggt acc tgt      776
 Met Gln Thr Cys Gly Asn Val Ser Asn Gln Phe Gln Leu Gly Thr Cys
         150                 155                 160

 cgg ctt ggc tgg gcc tat tac tgt gct gga ggt gga gca gct gca gcc      824
 Arg Leu Gly Trp Ala Tyr Tyr Cys Ala Gly Gly Gly Ala Ala Ala Ala
     165                 170                 175

 atg ttg atc tgc acc tgg ctc tct tgc ttt gct gga aga aac ccc aag      872
 Met Leu Ile Cys Thr Trp Leu Ser Cys Phe Ala Gly Arg Asn Pro Lys
 180                 185                 190                 195

 cct gtc ata ttg gtg gag agc atc atg agg aat acc aat tct tat gct      920
 Pro Val Ile Leu Val Glu Ser Ile Met Arg Asn Thr Asn Ser Tyr Ala
                 200                 205                 210

 atg gag ctt gac cat tgc ctc aaa cct tga g ctttgaaaga agattggaga      971
 Met Glu Leu Asp His Cys Leu Lys Pro 
             215                 220

 gggtgggaaa ggggaggagg gagccctgaa aagaggtact aaggattagg ccatttgtca   1031

 tctgactgtc attagcatag cctagtgttt gcatgctttt taaactaatt gtcgttcatt   1091

 ttcacttatc tttaagccag taggtcactg gctgtttata aaattcatca gaggaaacat   1151

 tctcagacat ttctcagaac aacgaca                                       1178




      <210> 647
      <211> 859
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(502)

      <400> 647
 attatcgccg tgcagttcca ggagtaaggg gagcctgagg  atg gcc aag ttc ctt      55
                                              Met Ala Lys Phe Leu
                                                1               5

 tcc cag gac caa att aat gag tac aag gag tgc ttc tcc ctg tac gac      103
 Ser Gln Asp Gln Ile Asn Glu Tyr Lys Glu Cys Phe Ser Leu Tyr Asp
                  10                  15                  20

 aag cag cag aga ggg aag atc aag gcc aca gat ctt ctg gtg tcc atg      151
 Lys Gln Gln Arg Gly Lys Ile Lys Ala Thr Asp Leu Leu Val Ser Met
              25                  30                  35

 agg tgc cta ggg gcc agc ccc acg cct ggg gaa gtg cag cgg cac ctg      199
 Arg Cys Leu Gly Ala Ser Pro Thr Pro Gly Glu Val Gln Arg His Leu
          40                  45                  50

 cag act cat ggg ata gac aag aac gga gag ctg gac ttc tcc acc ttc      247
 Gln Thr His Gly Ile Asp Lys Asn Gly Glu Leu Asp Phe Ser Thr Phe
      55                  60                  65

 ctg acc atc atg cat atg caa atc aag caa gag gac cca aag aaa gaa      295
 Leu Thr Ile Met His Met Gln Ile Lys Gln Glu Asp Pro Lys Lys Glu
  70                  75                  80                  85

 atc ctt ctg gcc atg ctg atg gca gac aag gag aag aaa ggt tac atc      343
 Ile Leu Leu Ala Met Leu Met Ala Asp Lys Glu Lys Lys Gly Tyr Ile
                  90                  95                 100

 atg gcg tct gag ctg cgg tcg aaa ctc atg aaa ctg gga gag aag ctc      391
 Met Ala Ser Glu Leu Arg Ser Lys Leu Met Lys Leu Gly Glu Lys Leu
             105                 110                 115

 act cac aag gaa gtg gat gat ctt ttc aag gaa gca ggc att gaa cca      439
 Thr His Lys Glu Val Asp Asp Leu Phe Lys Glu Ala Gly Ile Glu Pro
         120                 125                 130

 aac ggc caa gtg aaa tat gac acg ttt atc cag agg atc acc att cct      487
 Asn Gly Gln Val Lys Tyr Asp Thr Phe Ile Gln Arg Ile Thr Ile Pro
     135                 140                 145

 gtg cga gac tac taa gggagccaag atcaagagag cagatgagag ccttcggggc      542
 Val Arg Asp Tyr 
 150

 ctgaaaacct agactgattc ctttttgtaa gggaagtcta gagatgacac aaccactgca    602

 tggcataagt accaataaat gatgtagcca tggcattgga taactgtaat aaggtctgtc    662

 ttgatttcgg tactaacatt agtctagcca tttgcagcat agtctagccc tatgatttgt    722

 agtcagggtt gtgtgccagt gctgcctctg caacatcatc ccctcaccca ttgtacttct    782

 caaagccttt ggacctcata aggatgaaga ttgtgactga aaataaatgg ttggcaactt    842

 caaaaaaaaa aacggca                                                   859




      <210> 648
      <211> 1101
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (320)..(928)

      <400> 648
 gggtgcctga tgaaagaggt gagttcgagc ccacagcgaa gaagcccctt cagtgtggag     60

 gacccaatga cggtatctgg tacagactta aagaacagaa ggagtcttct aagggccatc    120

 taaagtgctg gagtgcagct tgccattgcc agttcagtgt ttgtggtcaa ctaggcttgt    180

 cgttttgcat gttgctctga cagggtgtag gcacacccag agaattcgga gacgtaaact    240

 ggattacgat gaattgtatc ctgagagcaa cagaccacag gaacaaagag taacatgaaa    300

 acaaaccctg ctgaagaat atg aag aaa aac cga gaa agg ttc tgc aac aag     352
                      Met Lys Lys Asn Arg Glu Arg Phe Cys Asn Lys
                        1               5                  10

 gaa agg gaa ttt gtg tac aag ttc cag gta gga cgt gag cgc tta gag      400
 Glu Arg Glu Phe Val Tyr Lys Phe Gln Val Gly Arg Glu Arg Leu Glu
              15                  20                  25

 ctg aga gtg ccc ctc agg ttt cct gtg gag gag aat gcc agt cat ctg      448
 Leu Arg Val Pro Leu Arg Phe Pro Val Glu Glu Asn Ala Ser His Leu
          30                  35                  40

 cat gga cgt ctg atg ctg ctg cac agc ttg cct tgc ttc ata gag agt      496
 His Gly Arg Leu Met Leu Leu His Ser Leu Pro Cys Phe Ile Glu Ser
      45                  50                  55

 gac tta aaa gat gct ctg agc cgg ttt ata gaa gaa gaa tcc ctc aga      544
 Asp Leu Lys Asp Ala Leu Ser Arg Phe Ile Glu Glu Glu Ser Leu Arg
  60                  65                  70                  75

 gac cat gac agc gat gca gaa gca tgc ttg gag gcc gtt aaa tcc ggt      592
 Asp His Asp Ser Asp Ala Glu Ala Cys Leu Glu Ala Val Lys Ser Gly
                  80                  85                  90

 gaa gta gat ctg cac cag ctg gca agt gcg tgg gcc aaa gct tac gct      640
 Glu Val Asp Leu His Gln Leu Ala Ser Ala Trp Ala Lys Ala Tyr Ala
              95                 100                 105

 gag acc acc tta gag cat gcg aga cct gag gag cct gac tgg gac gaa      688
 Glu Thr Thr Leu Glu His Ala Arg Pro Glu Glu Pro Asp Trp Asp Glu
         110                 115                 120

 gac ttt gca gat gtg tac cat gac cta atc cac tcc ccg gcc tct gaa      736
 Asp Phe Ala Asp Val Tyr His Asp Leu Ile His Ser Pro Ala Ser Glu
     125                 130                 135

 act ctc tta aat ctg gaa cac aac tac ttc gtt agc atc tca gag ctg      784
 Thr Leu Leu Asn Leu Glu His Asn Tyr Phe Val Ser Ile Ser Glu Leu
 140                 145                 150                 155

 att ggt gaa aga gac gtg gag ctg aaa aag tta cga gag aga caa ggt      832
 Ile Gly Glu Arg Asp Val Glu Leu Lys Lys Leu Arg Glu Arg Gln Gly
                 160                 165                 170

 att gaa atg gaa aag gtg atg cag gag cat cag acg tcc atg cag atg      880
 Ile Glu Met Glu Lys Val Met Gln Glu His Gln Thr Ser Met Gln Met
             175                 180                 185

 act ggc att ctc ctc cac agg aaa cct gag ggg cac tct cag ctc taa      928
 Thr Gly Ile Leu Leu His Arg Lys Pro Glu Gly His Ser Gln Leu 
         190                 195                 200

 gcgctcacgt cctacctgga acttgtacac aaattccctt tccttgttgc agaacctttc    988

 tcggtttttc ttcatattct tcagcagggt ttctctttca tcagacacca aagcacactt   1048

 ggagctgtca acgcagaact gcccccgcgc gttctgtgcg gtgatcccag tgc          1101




      <210> 649
      <211> 1708
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (214)..(1311)

      <400> 649
 gaggagacac aggcgctggc tgccccgtcc gctctccgcc tccgccgcgc cctcctcgcc     60

 cgggatgggc ccccccgccg ccgccggatc cctcgcctcc cggccgccgc cgttgcgctc    120

 gccggctcgc actgaagccc gggccctcgc gcgccgcggt tcgccccgca gcctcgcccc    180

 ctgcccaccc cgggcggccg tagggcggtc acg atg ctg ccg ccc tta ccc tcc     234
                                      Met Leu Pro Pro Leu Pro Ser
                                        1               5

 cgc ctc ggg ctg ctg ctg ctg ctg ctc ctg tgc ccg gcg cac gtc ggc      282
 Arg Leu Gly Leu Leu Leu Leu Leu Leu Leu Cys Pro Ala His Val Gly
          10                  15                  20

 gga ctg tgg tgg gct gtg ggc agc ccc ttg gtt atg gac cct acc agc      330
 Gly Leu Trp Trp Ala Val Gly Ser Pro Leu Val Met Asp Pro Thr Ser
      25                  30                  35

 atc tgc agg aag gca cgg cgg ctg gcc ggg cgg cag gcc gag ttg tgc      378
 Ile Cys Arg Lys Ala Arg Arg Leu Ala Gly Arg Gln Ala Glu Leu Cys
  40                  45                  50                  55

 cag gct gag ccg gaa gtg gtg gca gag cta gct cgg ggc gcc cgg ctc      426
 Gln Ala Glu Pro Glu Val Val Ala Glu Leu Ala Arg Gly Ala Arg Leu
                  60                  65                  70

 ggg gtg cga gag tgc cag ttc cag ttc cgc ttc cgc cgc tgg aat tgc      474
 Gly Val Arg Glu Cys Gln Phe Gln Phe Arg Phe Arg Arg Trp Asn Cys
              75                  80                  85

 tcc agc cac agc aag gcc ttt gga cgc atc ctg caa cag gac att cgg      522
 Ser Ser His Ser Lys Ala Phe Gly Arg Ile Leu Gln Gln Asp Ile Arg
          90                  95                 100

 gag acg gcc ttc gtg ttc gcc atc act gcg gcc ggc gcc agc cac gcc      570
 Glu Thr Ala Phe Val Phe Ala Ile Thr Ala Ala Gly Ala Ser His Ala
     105                 110                 115

 gtc acg cag gcc tgt tct atg ggc gag ctg ctg cag tgc ggc tgc cag      618
 Val Thr Gln Ala Cys Ser Met Gly Glu Leu Leu Gln Cys Gly Cys Gln
 120                 125                 130                 135

 gcg ccc cgc ggg cgg gcc cct ccc cgg ccc tcc ggc ctg ccc ggc acc      666
 Ala Pro Arg Gly Arg Ala Pro Pro Arg Pro Ser Gly Leu Pro Gly Thr
                 140                 145                 150

 ccc gga ccc cct ggc ccc gcg ggc tcc ccg gaa ggc agc gcc gcc tgg      714
 Pro Gly Pro Pro Gly Pro Ala Gly Ser Pro Glu Gly Ser Ala Ala Trp
             155                 160                 165

 gag tgg gga ggc tgc ggc gac gac gtg gac ttc ggg gac gag aag tcg      762
 Glu Trp Gly Gly Cys Gly Asp Asp Val Asp Phe Gly Asp Glu Lys Ser
         170                 175                 180

 agg ctc ttt atg gac gcg cgg cac aag cgg gga cgc gga gac atc cgc      810
 Arg Leu Phe Met Asp Ala Arg His Lys Arg Gly Arg Gly Asp Ile Arg
     185                 190                 195

 gcg ttg gtg caa ctg cac aac aac gag gcg ggc agg ctg gcc gtg cgg      858
 Ala Leu Val Gln Leu His Asn Asn Glu Ala Gly Arg Leu Ala Val Arg
 200                 205                 210                 215

 agc cac acg cgc acc gag tgc aaa tgc cac ggg ctg tcg gga tca tgc      906
 Ser His Thr Arg Thr Glu Cys Lys Cys His Gly Leu Ser Gly Ser Cys
                 220                 225                 230

 gcg ctg cgc acc tgc tgg cag aag ctg cct cca ttt cgc gag gtg ggc      954
 Ala Leu Arg Thr Cys Trp Gln Lys Leu Pro Pro Phe Arg Glu Val Gly
             235                 240                 245

 gcg cgg ctg ctg gag cgc ttc cac ggc gcc tca cgc gtc atg ggc acc     1002
 Ala Arg Leu Leu Glu Arg Phe His Gly Ala Ser Arg Val Met Gly Thr
         250                 255                 260

 aac gac ggc aag gcc ctg ctg ccc gcc gtc cgc acg ctc aag ccg ccg     1050
 Asn Asp Gly Lys Ala Leu Leu Pro Ala Val Arg Thr Leu Lys Pro Pro
     265                 270                 275

 ggc cga gcg gac ctc ctc tac gcc gcc gat tcg ccc gac ttc tgc gcc     1098
 Gly Arg Ala Asp Leu Leu Tyr Ala Ala Asp Ser Pro Asp Phe Cys Ala
 280                 285                 290                 295

 ccc aac cga cgc acc ggc tcc ccc ggc acg cgc ggt cgc gcc tgc aat     1146
 Pro Asn Arg Arg Thr Gly Ser Pro Gly Thr Arg Gly Arg Ala Cys Asn
                 300                 305                 310

 agc agc gcc ccg gac ctc agc ggc tgc gac ctg ctg tgc tgc ggc cgc     1194
 Ser Ser Ala Pro Asp Leu Ser Gly Cys Asp Leu Leu Cys Cys Gly Arg
             315                 320                 325

 ggg cac cgc cag gag agc gtg cag ctc gaa gag aac tgc ctg tgc cgc     1242
 Gly His Arg Gln Glu Ser Val Gln Leu Glu Glu Asn Cys Leu Cys Arg
         330                 335                 340

 ttc cac tgg tgc tgc gta gta cag tgc cac cgc tgc cgt gtg cgc aag     1290
 Phe His Trp Cys Cys Val Val Gln Cys His Arg Cys Arg Val Arg Lys
     345                 350                 355

 gag ctc agc ctc tgc ctg tga cc cgccgcccgg ccgctagact gacttcgcgc     1343
 Glu Leu Ser Leu Cys Leu 
 360                 365

 agcggtggct cgcacctgtg ggacctcagg gcaccggcac cgggcgcctc tcgccgctcg   1403

 agcccagcct ctccctgcca aagcccaact cccagggctc tggaaatggt gaggcgaggg   1463

 gcttgagagg aacgcccacc cacgaaggcc cagggcgcca gacggccccg aaaaggcgct   1523

 cggggagcgt ttaaaggaca ctgtacaggc cctccctccc cttggcctct aggaggaaac   1583

 agttttttag actggaaaaa agccagtcta aaggcctctg gatactgggc tccccagaac   1643

 tgctggccac aggatggtgg gtgaggttag tatcaataaa gatatttaaa ccaccaaaaa   1703

 aaaaa                                                               1708




      <210> 650
      <211> 1159
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (248)..(604)

      <400> 650
 caacgtccct accgccgccg cttcccggga acctggcgcc gccggaactg atcgcgtgct     60

 agtcccgacg cgtgtgtgct agtgagccgg agccggcgac ggcggcagtg gcggcccggc    120

 ctgcaggagc ccgacggggt ctctgccatg ggggagtgac gcgcctgcac ccgctgttcc    180

 gcggcagcgg cgagacatga ggagaccccg cgacaggggc aggcggcggc ggctcgtgag    240

 ccccggg  atg gag gag aaa tac ggc ggg gac gtg ctg gcc ggc ccg cgc     289
          Met Glu Glu Lys Tyr Gly Gly Asp Val Leu Ala Gly Pro Arg
            1               5                  10

 ggc ggc ggc ggc ctt ggg ccg gtg gac gta ccc agc gct cga tta aca      337
 Gly Gly Gly Gly Leu Gly Pro Val Asp Val Pro Ser Ala Arg Leu Thr
  15                  20                  25                  30

 aaa tat att gtg tta cta tgt ttc act aaa ttt ttg aag gct gtg gga      385
 Lys Tyr Ile Val Leu Leu Cys Phe Thr Lys Phe Leu Lys Ala Val Gly
                  35                  40                  45

 ctt ttc gaa tca tat gat ctc cta aaa gct gtt cac att gtt cag ttc      433
 Leu Phe Glu Ser Tyr Asp Leu Leu Lys Ala Val His Ile Val Gln Phe
              50                  55                  60

 att ttt ata tta aaa ctt ggg act gca ttt ttt atg gtt ttg ttt caa      481
 Ile Phe Ile Leu Lys Leu Gly Thr Ala Phe Phe Met Val Leu Phe Gln
          65                  70                  75

 aag cca ttt tct tct ggg aaa act att acc aaa cac cag ata att gga      529
 Lys Pro Phe Ser Ser Gly Lys Thr Ile Thr Lys His Gln Ile Ile Gly
      80                  85                  90

 tca cta aaa att cct ggt aga aaa gaa ttt aaa gac aaa aag tta aat      577
 Ser Leu Lys Ile Pro Gly Arg Lys Glu Phe Lys Asp Lys Lys Leu Asn
  95                 100                 105                 110

 gat cct agg aaa cta gtg gga aac tga gaaat cataaaattg tactctgaag      629
 Asp Pro Arg Lys Leu Val Gly Asn 
                 115

 aaaaagattt caaaatctac cagcagacaa gaatatagat aatggaaaac agaatactgt    689

 cctttttttt gccttccttt tttgggggaa aggagtcttg gtccattcgc ccaggcttgc    749

 tgtgcgttga cacggatctt tgtctcactg gcagcttgtg cctcccgggg tccaagcgaa    809

 ttctcctggc taaggctcct ggagtaagct ggaacttcag gggccgcagc aacaaaaccc    869

 aggtcatttt gggatttttc aggtgaacac gggcggttat tcaccacatt ttgccaggcg    929

 tggtgttgta aaactccgta cgccccaggg aaacgggcct gccactgggg ctacaacagg    989

 ggtctcggct ttcaagggca taggcaaagg cccggccccg aaaaagaatg tggtgtgggc   1049

 actaactaca gtacgcgagc gttgttttta ttcacaagat ttaggtgcgc cacactacgt   1109

 gtattcgctc tcttcttcaa ggggtcagta gctaatccac agataatgtg              1159




      <210> 651
      <211> 780
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (253)..(519)

      <220>
      <221> misc_feature
      <222> (1)...(780)
      <223> n = a,t,c or g

      <400> 651
 agggcgnnnn nnttttgaac gcttgcanga actcggcacg aggcggccca ggagaagcag     60

 ttcctgccgg cgctgctgag tttcttcatc tacaacccgc gcttctggcc gcgggaagga    120

 gaggttgttc ggaatcctat aattgaaaaa cagtaaagat ggaaaaccag ttattgaata    180

 tcaagaggag gagttgttga agtctcaggg gatccagaac tgcagccagt ccttgctggg    240

 ctgttcctgt cc    atg tgc ctg gtc acg gtg ctg ggg aac ctg ctc atc     288
                  Met Cys Leu Val Thr Val Leu Gly Asn Leu Leu Ile
                    1               5                  10

 atc ctg gcc atc agc cct gac tcc cac ctc cac acc ccc atg tac ttc      336
 Ile Leu Ala Ile Ser Pro Asp Ser His Leu His Thr Pro Met Tyr Phe
          15                  20                  25

 ttc ctc tcc aac ctg tcc ttg cct gac atc ggt ttc acc tcc acc acg      384
 Phe Leu Ser Asn Leu Ser Leu Pro Asp Ile Gly Phe Thr Ser Thr Thr
      30                  35                  40

 gtc ccc aag atg att gtg gac atc cag tct cac agc aga gtc atc tcc      432
 Val Pro Lys Met Ile Val Asp Ile Gln Ser His Ser Arg Val Ile Ser
  45                  50                  55                  60

 tat gca ggc tgc ctg act cag atg tct ctc ttt gcc att ttt gga ggc      480
 Tyr Ala Gly Cys Leu Thr Gln Met Ser Leu Phe Ala Ile Phe Gly Gly
                  65                  70                  75

 atg gaa gag aga cat gct cct gag tgt gat ggc cta tga ctggtttgta       529
 Met Glu Glu Arg His Ala Pro Glu Cys Asp Gly Leu 
              80                  85

 gccatctgtc acccgctata tcattcacca tcatgaaccc gtgtttctgt gcctttctag    589

 ttttgttgtc tttttttttc tcagtctttt agactcccag ctgcacaact tgattgcctt    649

 acaagtgacc tgcttcaagg atgtggaaat tcctaatttc ttctgtgacc cttctcaact    709

 ctcccatctt gcatgttgtg acaccttcac cattaacata atcatgtatt tcaaaaaaaa    769

 aaaaaaaaaa a                                                         780




      <210> 652
      <211> 2900
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(1964)

      <400> 652
 atgccagggt ggagagttgt gcgccggtcc ctgggcctga gctccggctc cggctggggc     60

 gcctgcgatg tctcaag   atg gcg gag ctg ggc gaa tta aag cac atg gtg     110
                      Met Ala Glu Leu Gly Glu Leu Lys His Met Val
                        1               5                  10

 atg agt ttc cgg gtg tct gag ctc cag gtg ctt ctt ggc ttt gct ggc      158
 Met Ser Phe Arg Val Ser Glu Leu Gln Val Leu Leu Gly Phe Ala Gly
              15                  20                  25

 cgg aac aag agt gga cgg aag cac gag ctc ctg gcc aag gct ctg cac      206
 Arg Asn Lys Ser Gly Arg Lys His Glu Leu Leu Ala Lys Ala Leu His
          30                  35                  40

 ctc ctg aag tcc agc tgt gcc cct agt gtc cag atg aag atc aaa gag      254
 Leu Leu Lys Ser Ser Cys Ala Pro Ser Val Gln Met Lys Ile Lys Glu
      45                  50                  55

 ctt tac cga cga cgc ttt ccc cgg aag acc ctg ggg ccc tct gat ctc      302
 Leu Tyr Arg Arg Arg Phe Pro Arg Lys Thr Leu Gly Pro Ser Asp Leu
  60                  65                  70                  75

 tcc ctt ctc tct ttg ccc cct ggc acc tct cct gta ggc tcc cct ggt      350
 Ser Leu Leu Ser Leu Pro Pro Gly Thr Ser Pro Val Gly Ser Pro Gly
                  80                  85                  90

 cct cta gct ccc att ccc cca acg ctg ttg gcc cct ggc acc ctg ctg      398
 Pro Leu Ala Pro Ile Pro Pro Thr Leu Leu Ala Pro Gly Thr Leu Leu
              95                 100                 105

 ggc ccc aag cgt gag gtg gac atg cac ccc cct ctg ccc cag cct gtg      446
 Gly Pro Lys Arg Glu Val Asp Met His Pro Pro Leu Pro Gln Pro Val
         110                 115                 120

 cac cct gat gtc acc atg aaa cca ttg ccc ttc tat gaa gtc tat ggg      494
 His Pro Asp Val Thr Met Lys Pro Leu Pro Phe Tyr Glu Val Tyr Gly
     125                 130                 135

 gag ctc atc cgg ccc acc acc ctt gca tcc act tct agc cag cgg ttt      542
 Glu Leu Ile Arg Pro Thr Thr Leu Ala Ser Thr Ser Ser Gln Arg Phe
 140                 145                 150                 155

 gag gaa gcg cac ttt acc ttt gcc ctc aca ccc cag caa gtg cag cag      590
 Glu Glu Ala His Phe Thr Phe Ala Leu Thr Pro Gln Gln Val Gln Gln
                 160                 165                 170

 att ctt aca tcc aga gag gtt ctg cca gga gcc aaa tgt gat tat acc      638
 Ile Leu Thr Ser Arg Glu Val Leu Pro Gly Ala Lys Cys Asp Tyr Thr
             175                 180                 185

 ata cag gtg cag cta agg ttc tgt ctc tgt gag acc agc tgc ccc cag      686
 Ile Gln Val Gln Leu Arg Phe Cys Leu Cys Glu Thr Ser Cys Pro Gln
         190                 195                 200

 gaa gat tat ttt ccc ccc aac ctc ttt gtc aag gtc aat ggg aaa ctg      734
 Glu Asp Tyr Phe Pro Pro Asn Leu Phe Val Lys Val Asn Gly Lys Leu
     205                 210                 215

 tgc ccc ctg ccg ggt tac ctt ccc cca acc aag aat ggg gcc gag ccc      782
 Cys Pro Leu Pro Gly Tyr Leu Pro Pro Thr Lys Asn Gly Ala Glu Pro
 220                 225                 230                 235

 aag agg ccc agc cgc ccc atc aac atc aca ccc ctg gct cga ctc tca      830
 Lys Arg Pro Ser Arg Pro Ile Asn Ile Thr Pro Leu Ala Arg Leu Ser
                 240                 245                 250

 gcc act gtt ccc aac acc att gtg gtc aat tgg tca tct gag ttc gga      878
 Ala Thr Val Pro Asn Thr Ile Val Val Asn Trp Ser Ser Glu Phe Gly
             255                 260                 265

 cgg aat tac tcc ttg tct gtg tac ctg gtg agg cag ttg act gca gga      926
 Arg Asn Tyr Ser Leu Ser Val Tyr Leu Val Arg Gln Leu Thr Ala Gly
         270                 275                 280

 acc ctt cta caa aaa ctc aga gca aag ggt atc cgg aac cca gac cac      974
 Thr Leu Leu Gln Lys Leu Arg Ala Lys Gly Ile Arg Asn Pro Asp His
     285                 290                 295

 tcg cgg gca ctg atc aag gag aaa ttg act gct gac cct gac agt gag     1022
 Ser Arg Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu
 300                 305                 310                 315

 gtg gcc act aca agt ctc cgg gtg tca ctc atg tgc ccg cta ggg aag     1070
 Val Ala Thr Thr Ser Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys
                 320                 325                 330

 atg cgc ctg act gtc cct tgt cgt gcc ctc acc tgc gcc cac ctg cag     1118
 Met Arg Leu Thr Val Pro Cys Arg Ala Leu Thr Cys Ala His Leu Gln
             335                 340                 345

 agc ttc gat gct gcc ctt tat cta cag atg aat gag aag aag cct aca     1166
 Ser Phe Asp Ala Ala Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr
         350                 355                 360

 tgg aca tgt cct gtg tgt gac aag aag gct ccc tat gaa tct ctt atc     1214
 Trp Thr Cys Pro Val Cys Asp Lys Lys Ala Pro Tyr Glu Ser Leu Ile
     365                 370                 375

 att gat ggt tta ttt atg gag att ctt agt tcc tgt tca gat tgt gat     1262
 Ile Asp Gly Leu Phe Met Glu Ile Leu Ser Ser Cys Ser Asp Cys Asp
 380                 385                 390                 395

 gag atc caa ttc atg gaa gat gga tcc tgg tgc cca atg aaa ccc aag     1310
 Glu Ile Gln Phe Met Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys
                 400                 405                 410

 aag gag gca tct gag gtt tgc ccc ccg cca ggg tat ggg ctg gat ggc     1358
 Lys Glu Ala Ser Glu Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly
             415                 420                 425

 ctc cag tac agc cca gtc cag ggg gga gat cca tca gag aat aag aag     1406
 Leu Gln Tyr Ser Pro Val Gln Gly Gly Asp Pro Ser Glu Asn Lys Lys
         430                 435                 440

 aag gtc gaa gtt att gac ttg aca ata gaa agc tca tca gat gag gag     1454
 Lys Val Glu Val Ile Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu
     445                 450                 455

 gat ctg ccc cct acc aag aag cac tgt tct gtc acc tca gct gcc atc     1502
 Asp Leu Pro Pro Thr Lys Lys His Cys Ser Val Thr Ser Ala Ala Ile
 460                 465                 470                 475

 ccg gcc cta cct gga agc aaa gga gtc ctg aca tct ggc cac cag cca     1550
 Pro Ala Leu Pro Gly Ser Lys Gly Val Leu Thr Ser Gly His Gln Pro
                 480                 485                 490

 tcc tcg gtg cta agg agc cct gct atg ggc acg ttg ggt ggg gat ttc     1598
 Ser Ser Val Leu Arg Ser Pro Ala Met Gly Thr Leu Gly Gly Asp Phe
             495                 500                 505

 ctg tcc agt ctc cca cta cat gag tac cca cct gcc ttc cca ctg gga     1646
 Leu Ser Ser Leu Pro Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly
         510                 515                 520

 gcc gac atc caa ggt tta gat tta ttt tca ttt ctt cag aca gag agt     1694
 Ala Asp Ile Gln Gly Leu Asp Leu Phe Ser Phe Leu Gln Thr Glu Ser
     525                 530                 535

 cag cac tat ggc ccc tct gtc atc acc tca cta gat gaa cag gat gcc     1742
 Gln His Tyr Gly Pro Ser Val Ile Thr Ser Leu Asp Glu Gln Asp Ala
 540                 545                 550                 555

 ctt ggc cac ttc ttc cag tac cga ggg acc cct tct cac ttt ctg ggc     1790
 Leu Gly His Phe Phe Gln Tyr Arg Gly Thr Pro Ser His Phe Leu Gly
                 560                 565                 570

 cca ctg gcc ccc acg ctg ggg agc tcc cac tgc agc gcc act ccg gcg     1838
 Pro Leu Ala Pro Thr Leu Gly Ser Ser His Cys Ser Ala Thr Pro Ala
             575                 580                 585

 ccc cct cct ggc cgt gtc agc agc att gtg gcc cct ggg ggg gcc ttg     1886
 Pro Pro Pro Gly Arg Val Ser Ser Ile Val Ala Pro Gly Gly Ala Leu
         590                 595                 600

 agg gag ggg cat gga gga ccc ctg ccc tca ggt ccc tct ttg act ggc     1934
 Arg Glu Gly His Gly Gly Pro Leu Pro Ser Gly Pro Ser Leu Thr Gly
     605                 610                 615

 tgt cgg tca gac atc att tcc ctg gac tga g ttccctggat tatggaaact     1985
 Cys Arg Ser Asp Ile Ile Ser Leu Asp 
 620                 625

 tcgctgtccc ccaacactga gcaagtatgc tgtggagtcc caaccccagc tactctgatc   2045

 cctctggggg ctctggccaa gggccagaca gaccttcaca gatgcctact tttggcctca   2105

 tctctgcctg acaaggccag cacccaaagg gttaatattt aacctctttt taaggacact   2165

 ggggtctgtt tctggaaatg ttctttagat ggtggcacat tcctttgggt atgttaacct   2225

 aggcagtggg aggcaaatgg gatggtatgt gagctaggag aagggctgaa ccctcagcct   2285

 tgactatgtc tagagcctct tggggaaggg gcacctctct tgaaccccaa atgctctctc   2345

 ttcttattac ccaaacccat ggctctattt cttcttcaca tccattgtct cttcatgtct   2405

 attccattcc cttcggccaa acagacaggt ggaaaaactg agacaggcag tttcagagat   2465

 ggacagagaa ctttattttg gattgtggat gtggactttt ttgtacataa ataagaaaaa   2525

 ccaaaatact ccaaagatga cttcccctgc ctcctactcc agtatgacag aggaggatgt   2585

 aaggccttag ccatgatctg caggggtctg ggagtcaggc ccggcctatt gcttgggtct   2645

 ctctctattt atatatctaa gttcacagtg tttcttattc ccccctaagc ttctagaggc   2705

 tcatggccct gtagttaggc ctggctcatt ctgcaccttt ccagggaggt ggaaggaccc   2765

 tgtgccctcc ttcccaatct tctttttcag gctcgccaag gcctaggacc tatgttgtaa   2825

 ttttactttt tatttctaaa gttgtagtga agctctcacc cataataaag gttgtgaatg   2885

 ttcaaaaaaa aaaaa                                                    2900




      <210> 653
      <211> 1458
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (273)..(1265)

      <400> 653
 aaggatcctt aattaaatta atcccccccc ccccccgagc catatggggg atacgccagc     60

 aacagacgcc ggccgccaag atctgcatcc ctaggccacg ctaagaccct ggggaagagc    120

 gcaggagccc gggagaaggg ctggaaggag gggactggac gtgcggagaa ttccccccta    180

 aaaggcagaa gcccccgccc ccaccctcga gctccgctcg ggcagagcgc ctgcctgcct    240

 gccgctgctg cgggcgccca cctcgcccag cc  atg cca ggc ccg gcc acc gac     293
                                      Met Pro Gly Pro Ala Thr Asp
                                        1               5

 gcg ggg aag atc cct ttc tgc gac gcc aag gaa gaa atc cgt gcc ggg      341
 Ala Gly Lys Ile Pro Phe Cys Asp Ala Lys Glu Glu Ile Arg Ala Gly
          10                  15                  20

 ctc gaa agc tct gag ggc ggc ggc ggc ccg gag agg cca ggc gcg cgc      389
 Leu Glu Ser Ser Glu Gly Gly Gly Gly Pro Glu Arg Pro Gly Ala Arg
      25                  30                  35

 ggg cag cgg cag aac atc gtc tgg agg aat gtc gtc ctg atg agc ttg      437
 Gly Gln Arg Gln Asn Ile Val Trp Arg Asn Val Val Leu Met Ser Leu
  40                  45                  50                  55

 ctc cac ttg ggg gcc gtg tac tcc ctg gtg ctc atc ccc aaa gcc aag      485
 Leu His Leu Gly Ala Val Tyr Ser Leu Val Leu Ile Pro Lys Ala Lys
                  60                  65                  70

 cca ctc act ctg ctc tgg gcc tac ttc tgc ttc ctc ctg gcc gct ctg      533
 Pro Leu Thr Leu Leu Trp Ala Tyr Phe Cys Phe Leu Leu Ala Ala Leu
              75                  80                  85

 ggt gtg aca gct ggt gcc cat cgc ttg tgg agc cac agg tcc tac cgg      581
 Gly Val Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Ser Tyr Arg
          90                  95                 100

 gcc aag ctg cct ctg agg ata ttt ctg gct gtc gcc aac tcc atg gct      629
 Ala Lys Leu Pro Leu Arg Ile Phe Leu Ala Val Ala Asn Ser Met Ala
     105                 110                 115

 ttc cag aat gac atc ttc gag tgg tcc agg gac cac cga gcc cac cac      677
 Phe Gln Asn Asp Ile Phe Glu Trp Ser Arg Asp His Arg Ala His His
 120                 125                 130                 135

 aag tac tca gag acg gat gct gac ccc cac aat gcc cgc cgg ggc ttc      725
 Lys Tyr Ser Glu Thr Asp Ala Asp Pro His Asn Ala Arg Arg Gly Phe
                 140                 145                 150

 ttc ttc tcc cat att ggg tgg ctg ttt gtt cgc aag cat cga gat gtt      773
 Phe Phe Ser His Ile Gly Trp Leu Phe Val Arg Lys His Arg Asp Val
             155                 160                 165

 att gag aag ggg aga aag ctt gac gtc act gac ctg ctt gct gat cct      821
 Ile Glu Lys Gly Arg Lys Leu Asp Val Thr Asp Leu Leu Ala Asp Pro
         170                 175                 180

 gtg gtc cgg atc cag aga aag tac tat aag atc tcc gtg gtg ctc atg      869
 Val Val Arg Ile Gln Arg Lys Tyr Tyr Lys Ile Ser Val Val Leu Met
     185                 190                 195

 tgc ttt gtg gtc ccc acg ctg gtg ccc tgg tac atc tgg gga gag agt      917
 Cys Phe Val Val Pro Thr Leu Val Pro Trp Tyr Ile Trp Gly Glu Ser
 200                 205                 210                 215

 ctg tgg aat tcc tac ttc ttg gcc tct att ctc cgc tat acc atc tca      965
 Leu Trp Asn Ser Tyr Phe Leu Ala Ser Ile Leu Arg Tyr Thr Ile Ser
                 220                 225                 230

 ctc aac atc agc tgg ctg gtc aac agc gcc gcc cac atg tat gga aac     1013
 Leu Asn Ile Ser Trp Leu Val Asn Ser Ala Ala His Met Tyr Gly Asn
             235                 240                 245

 cgg ccc tat gac aag cac atc agc cct cgg cag aac cca ctc gtc gct     1061
 Arg Pro Tyr Asp Lys His Ile Ser Pro Arg Gln Asn Pro Leu Val Ala
         250                 255                 260

 ctg ggt gcc att ggt gaa ggc ttc cat aat tac cat cac acc ttt ccc     1109
 Leu Gly Ala Ile Gly Glu Gly Phe His Asn Tyr His His Thr Phe Pro
     265                 270                 275

 ttt gac tac tct gcg agt gaa ttt ggc tta aat ttt aac cca acc acc     1157
 Phe Asp Tyr Ser Ala Ser Glu Phe Gly Leu Asn Phe Asn Pro Thr Thr
 280                 285                 290                 295

 tgg ttc att gat ttc atg tgc tgg ctg ggg ctg gcc act gac cgc aaa     1205
 Trp Phe Ile Asp Phe Met Cys Trp Leu Gly Leu Ala Thr Asp Arg Lys
                 300                 305                 310

 cgg gca acc aag ccg atg atc gag gcc cgg aag gcc agg act gga gac     1253
 Arg Ala Thr Lys Pro Met Ile Glu Ala Arg Lys Ala Arg Thr Gly Asp
             315                 320                 325

 agc agt gct tga act tggaacagcc atcccacatg tctgccgttg caacctcggt     1308
 Ser Ser Ala 
         330

 tcatggcttt ggttacaata gctctcttgt acattggatc gtgggagggg gcagagggtg   1368

 gggaaggaac gagtcaatgt ggtttgggaa tgtttttgtt tatctcaaaa taatgttgaa   1428

 atacaattat caatgaaaaa aaaaaaaaaa                                    1458




      <210> 654
      <211> 2696
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (826)..(1887)

      <400> 654
 aaggatcctt aattaaatta atcccccccc ccccccggcg gggcggacgc cgctcgccgg     60

 ctggccccat cctccactgc agcagtaacg tcgcggcggg ttgcgggtag gactggacgc    120

 cagggcagcc gcgcagcgcc tgaaccgctg cgggccgccg cggccgcccc ttcccaccct    180

 cgcctctgct gtctccagcc tcgcttctcc gactttcctg ctcctctgct gccttcgttt    240

 ctggtcctcg gccgtcctcg ccgcccgccc agaggagtcc ccgcgcccgc caagaagccg    300

 ctttccgctg gcccgcagcc gccgcgactt cggcacagtt tctccctctg gctagtctcc    360

 caaacggccg ctcctcgccc gcgggaagac caggctgcga ccgcgaacgc ccgatcctct    420

 ccaggagccg cagcgagcgc ccggcggcca cgccccgcga ccacaccccg gcggctctcg    480

 gcccagcgcg cctgccttcg ccgcccgccg tcgctcctcg cccgctgcac gacgacgcga    540

 cgcccctgct gcaggcggcg gacccgaccg gacccagacc cagacgcaag atggcgacgg    600

 ccgcgtgact gcctcagcgt ccccgagctc ggctccgagt gcacctacgg actgactgtg    660

 ggggcagaga agggcgagat caggactctg tctttgttaa tcgtgactgc atgaaggtcg    720

 cctccctcgg gcctacttgg tgggagtgtc tggtattgtt ctaaggccag gagcacggtg    780

 agccacagtc tgttggtaga atttggcgtc ttgatagttg agaaa    atg gcg atg     834
                                                      Met Ala Met
                                                        1

 aca ctg ttg gaa gac tgg tgc cgg ggg atg gat gtg aac tcc cag aga      882
 Thr Leu Leu Glu Asp Trp Cys Arg Gly Met Asp Val Asn Ser Gln Arg
       5                  10                  15

 gct ctg tta gtc tgg ggc atc cca gtg aac tgt gat gag gct gaa atc      930
 Ala Leu Leu Val Trp Gly Ile Pro Val Asn Cys Asp Glu Ala Glu Ile
  20                  25                  30                  35

 gaa gag acc ctc cag gct gcg atg ccc cag gtc tcc tac cga atg ctt      978
 Glu Glu Thr Leu Gln Ala Ala Met Pro Gln Val Ser Tyr Arg Met Leu
                  40                  45                  50

 ggg aga atg ttc tgg agg gaa gaa aat gcg aaa gca gcc tta tta gag     1026
 Gly Arg Met Phe Trp Arg Glu Glu Asn Ala Lys Ala Ala Leu Leu Glu
              55                  60                  65

 ctc act ggc gct gta gat tac gcc gcg atc ccc agg gag atg ccg ggc     1074
 Leu Thr Gly Ala Val Asp Tyr Ala Ala Ile Pro Arg Glu Met Pro Gly
          70                  75                  80

 aaa gga ggg gtc tgg aaa gtg tta ttt aag ccc cca act tct gat gct     1122
 Lys Gly Gly Val Trp Lys Val Leu Phe Lys Pro Pro Thr Ser Asp Ala
      85                  90                  95

 gaa ttt tta gaa aga ttg cac ctc ttc cta gct aga gag ggg tgg acc     1170
 Glu Phe Leu Glu Arg Leu His Leu Phe Leu Ala Arg Glu Gly Trp Thr
 100                 105                 110                 115

 gtg caa gat gtt gcc cgt gtc ctt ggg ttt cag aac cct act ccg acc     1218
 Val Gln Asp Val Ala Arg Val Leu Gly Phe Gln Asn Pro Thr Pro Thr
                 120                 125                 130

 ccg ggc cca gag atg cca gca gag atg cta aac tat att ttg gat aat     1266
 Pro Gly Pro Glu Met Pro Ala Glu Met Leu Asn Tyr Ile Leu Asp Asn
             135                 140                 145

 gtt att cag cct ctt gtt gag tcc ata tgg tac aag agg ctg aca ctt     1314
 Val Ile Gln Pro Leu Val Glu Ser Ile Trp Tyr Lys Arg Leu Thr Leu
         150                 155                 160

 ttc tcg ggg agg gac atc cca ggg cct gga gag gaa acc ttt gat ccc     1362
 Phe Ser Gly Arg Asp Ile Pro Gly Pro Gly Glu Glu Thr Phe Asp Pro
     165                 170                 175

 tgg ctg gag cac act aat gag gtc cta gag gag tgg cag gtg tcc gat     1410
 Trp Leu Glu His Thr Asn Glu Val Leu Glu Glu Trp Gln Val Ser Asp
 180                 185                 190                 195

 gta gaa aag agg cgg cgg ttg atg gag agt ctt aga ggc ccc gcc gct     1458
 Val Glu Lys Arg Arg Arg Leu Met Glu Ser Leu Arg Gly Pro Ala Ala
                 200                 205                 210

 gat gtt att cgc atc ctt aag tcc aac aac ccc gcg ata acc act gcc     1506
 Asp Val Ile Arg Ile Leu Lys Ser Asn Asn Pro Ala Ile Thr Thr Ala
             215                 220                 225

 gaa tgc ctg aag gcg ctt gag cag gtg ttt ggg agc gtt gag agc tct     1554
 Glu Cys Leu Lys Ala Leu Glu Gln Val Phe Gly Ser Val Glu Ser Ser
         230                 235                 240

 agg gat gcc cag atc aaa ttt ctg aac act tat cag aac ccg gga gaa     1602
 Arg Asp Ala Gln Ile Lys Phe Leu Asn Thr Tyr Gln Asn Pro Gly Glu
     245                 250                 255

 aaa ttg tct gct tat gtc att cgt ctg gag cct ctg cta cag aag gtg     1650
 Lys Leu Ser Ala Tyr Val Ile Arg Leu Glu Pro Leu Leu Gln Lys Val
 260                 265                 270                 275

 gta gag aag ggg gcc att gat aaa gat aat gtg aac cag gcc cgc cta     1698
 Val Glu Lys Gly Ala Ile Asp Lys Asp Asn Val Asn Gln Ala Arg Leu
                 280                 285                 290

 gag cag gtc att gcc ggg gcc aac cac agc ggg gcc atc cga agg cag     1746
 Glu Gln Val Ile Ala Gly Ala Asn His Ser Gly Ala Ile Arg Arg Gln
             295                 300                 305

 ctg tgg ctt acc ggg gct ggg gaa ggg cca gcc cca aac ctc ttt cag     1794
 Leu Trp Leu Thr Gly Ala Gly Glu Gly Pro Ala Pro Asn Leu Phe Gln
         310                 315                 320

 ttg ctg gtg cag atc cgt gag gag gaa gcc aag gag gag gag gag gag     1842
 Leu Leu Val Gln Ile Arg Glu Glu Glu Ala Lys Glu Glu Glu Glu Glu
     325                 330                 335

 gct gag gcc acc ctt ctg cag tta ggc ctg gaa ggg cac ttc tga gtg     1890
 Ala Glu Ala Thr Leu Leu Gln Leu Gly Leu Glu Gly His Phe 
 340                 345                 350

 ccaggaaagg cagctttagt gcagacctag atcacagcta cttttcttgt ccctgtgggg   1950

 tcttacagat gtgtctctga gtagtaaagg cttagccttg ttctgttttg ttgttttttg   2010

 gaggggaagg ttagtcaggc ctgagtattc atgtaacatt ctaaaattgt gccagcgagc   2070

 accgtgaacg actgcaatgc aagcgggtct tgctggctaa aatgccaggt aaagggttgg   2130

 ttggacacag cgcttagtgc acgctgtcat catggacatc ataatcagtt gtgaaaaaca   2190

 cgcgaaccta tgacacttct tattccacac tgaatgtgaa attgcatgtt cagatgttta   2250

 ctacgaggcc tggctcacag gaagtgttca gtaaaagtat gcactgttag attactgata   2310

 acgcggatag atttttgttt accataaatt gttccagatt tatattaatg gaaggaagtg   2370

 tgcatttatt agctattact caactttaca atgcaaacat cttatttctc atctttaaac   2430

 atgtcgacca gtttaattga aaagtattct gagactgcaa aatggggtgt taaaaaatac   2490

 tgcagttacg gagctgtgta aaccagtttc tcattgcata agatacagat gtaaattgca   2550

 tggagaggtt gatatgcacc tgtacagtaa ttcactcccc catttcacat ctttgtcaga   2610

 gaatagttct tgttcatact gagtgttcta aatttgaagt tatatataca aattaaaata   2670

 ttttaaaaat tcaaaaaaaa aaaaaa                                        2696




      <210> 655
      <211> 2754
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1774)..(2754)

      <400> 655
 ggctgtggca cacaggccga acacgtggac acctgcgggg cggaaggctc ggccaggcgg     60

 ggagctgggg acccgggaca gccccacccc ctgcatgtgg aggtagctca gggtcggggc    120

 gcggcccgca actcacccac aaaccgcacc gtacgccgca ggaaggagtt gaagttgcag    180

 ccgccggcgt tgatgctgcc ctccgccccg gcgggccccc cggcacggcc ccacagccgg    240

 gactgcagac agtacaacat gccctcggcc accatgatct gccaacaggg agggggcgct    300

 caggcctcgg ctggcacagg ccccggtgca ggtgctcacc gaggcggcag gggccgcgaa    360

 ggccaagctg agcagcatca gcagcgggat gagctcctcg ttggtctcca cgtagggcat    420

 ggagagagtg cggtcatagc actggaagcc caccttggcc ggcttgaaga ggtcggtcag    480

 ctccaggaag tacaaggata cgatggaaga agccactatg ggcagatgga tggatgggtg    540

 aatgaatggc tgggtaatga atggatggat ggacggttgg atggatggct gcccatagtg    600

 gcttcttcca tcgtatcctt gtacttcctg gagctgaccg acctcttcaa gccggccaag    660

 gtgggcttcc agtgctatga ccgcactctc tccatgccct acgtggagac caacgaggag    720

 ctcatcccgc tgctgatgct gctcagcttg gccttcgcgg cccctgccgc ctcgatcatg    780

 gtggccgagg gcatgttgta ctgtctgcag tcccggctgt ggggccgtgc cggggggccc    840

 gccggggcgg agggcagcat caacgccggc ggctgcaact tcaactcctt cctgcggcgt    900

 acggtgcggt ttgtgggtgt ccacgtgttc ggcctgtgtg ccacagccct ggtgacggac    960

 gtgatccagc tggccacggg ttaccacact cccttcttcc tcaccgtctg caagcccaac   1020

 tacactctcc tgggcacgtc ctgcgaggtc aacccctaca tcacgcagga catctgctcc   1080

 ggccacgaca tccacgccat cctgtctgca cggaagacct tcccgtccca gcacgccacg   1140

 ctgtcagcct tcgccgcggt ctatgtgtcg gtgagtccgg cccctcactg cccttcccag   1200

 gccctcttgc tgacccgtgg ggagccctcc ctgaccccaa cccccatgcc ccagatgtac   1260

 ttcaactcgg tcatctcgga caccaccaag ctgctgaagc ccatcctggt cttcgccttt   1320

 gccatcgccg cgggcgtatg cgggctcacg cagatcacgc agtaccgcag ccaccctgtg   1380

 gacgtgtatg ccggcttcct catcggggcg ggcatcgctg cctacctggc ctgccacgcg   1440

 gtgggcaact tccaggcccc acctgcagag aagcccgcgg ccccggcccc cgccaaggac   1500

 gcgctgcggg ccctgacgca gcggggccac gactcggttt atcagcagaa taagtcggtg   1560

 agcaccgacg agctggggcc cccagggcgg ctggagggcg cgccccggcc cgtggcccgc   1620

 gagaagacct cgctgggcag cctgaagcgc gccagcgtgg acgtggacct gctggccccg   1680

 cgcagcccca tggccaagga gaacatggtg accttcagcc acacgctgcc cagggccagc   1740

 gcgccctcgc tggacgaccc cgcgcgccgc cac atg acc atc cac gtg ccg ctg    1794
                                      Met Thr Ile His Val Pro Leu
                                        1               5

 gac gcc tcg cgc tcc aag cag ctc atc agc gag tgg aag cag aag agc     1842
 Asp Ala Ser Arg Ser Lys Gln Leu Ile Ser Glu Trp Lys Gln Lys Ser
          10                  15                  20

 ctg gag ggc cgc ggc ctg ggg ctg ccc gac gac gcc agc ccc ggg cac     1890
 Leu Glu Gly Arg Gly Leu Gly Leu Pro Asp Asp Ala Ser Pro Gly His
      25                  30                  35

 ctg cgc gcg ccc gcc gaa ccc atg gcg gag gag gag gaa gag gag gag     1938
 Leu Arg Ala Pro Ala Glu Pro Met Ala Glu Glu Glu Glu Glu Glu Glu
  40                  45                  50                  55

 gac gaa gag gaa gag gag gag gag gaa gag gag gag gac gag ggc ccg     1986
 Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Gly Pro
                  60                  65                  70

 gcc ccg ccc tcg ctc tac ccc acc gtg cag gcg cgg ccg ggg ctg ggg     2034
 Ala Pro Pro Ser Leu Tyr Pro Thr Val Gln Ala Arg Pro Gly Leu Gly
              75                  80                  85

 cct cgg gtc atc ctc cca ccg cgc gcg ggg ccg ccg ccg ctg gtg cac     2082
 Pro Arg Val Ile Leu Pro Pro Arg Ala Gly Pro Pro Pro Leu Val His
          90                  95                 100

 atc ccg gag gag ggc gcg cag acg ggg gcc ggc ctg tcc ccc aaa agc     2130
 Ile Pro Glu Glu Gly Ala Gln Thr Gly Ala Gly Leu Ser Pro Lys Ser
     105                 110                 115

 ggc gcc ggg gtg cgc gcc aag tgg ctc atg atg gcc gag aag agc ggg     2178
 Gly Ala Gly Val Arg Ala Lys Trp Leu Met Met Ala Glu Lys Ser Gly
 120                 125                 130                 135

 gcg gca gtg gcc aac cct ccg cgg ctg ctg cag gtc atc gcc atg tcc     2226
 Ala Ala Val Ala Asn Pro Pro Arg Leu Leu Gln Val Ile Ala Met Ser
                 140                 145                 150

 aag gct ccg ggc gcg ccg ggc ccc aag gcg gcc gag acg gcg tcg tcg     2274
 Lys Ala Pro Gly Ala Pro Gly Pro Lys Ala Ala Glu Thr Ala Ser Ser
             155                 160                 165

 tcc agc gcc agc tcc gac tcc tcg cag tac cgg tcg ccg tcg gac cgc     2322
 Ser Ser Ala Ser Ser Asp Ser Ser Gln Tyr Arg Ser Pro Ser Asp Arg
         170                 175                 180

 gac tcc gcc agc atc gtg acc atc gac gcg cac gcg ccg cac cac ccc     2370
 Asp Ser Ala Ser Ile Val Thr Ile Asp Ala His Ala Pro His His Pro
     185                 190                 195

 gtg gtg cac ctg tcg gcc ggc ggc gcg ccc tgg gag tgg aag gcg gcg     2418
 Val Val His Leu Ser Ala Gly Gly Ala Pro Trp Glu Trp Lys Ala Ala
 200                 205                 210                 215

 ggc ggc ggg gcc aag gcg gag gcc gac ggc ggc tac gag ctg ggg gac     2466
 Gly Gly Gly Ala Lys Ala Glu Ala Asp Gly Gly Tyr Glu Leu Gly Asp
                 220                 225                 230

 ctg gcg cgc ggc ttc cgc ggc ggg gcc aag ccc ccg ggc gtg tcc ccc     2514
 Leu Ala Arg Gly Phe Arg Gly Gly Ala Lys Pro Pro Gly Val Ser Pro
             235                 240                 245

 ggc tcg tcg gtc agc gac gtg gac cag gag gag ccg cgg ttc ggg gcc     2562
 Gly Ser Ser Val Ser Asp Val Asp Gln Glu Glu Pro Arg Phe Gly Ala
         250                 255                 260

 gtg gcc acc gtc aac ctg gcc acg ggc gag ggg ctg ccc ccg ctg ggc     2610
 Val Ala Thr Val Asn Leu Ala Thr Gly Glu Gly Leu Pro Pro Leu Gly
     265                 270                 275

 gcg gcc gat ggg gcg ctg ggc ccg ggc agc cgg gag tcc acg ctg cgg     2658
 Ala Ala Asp Gly Ala Leu Gly Pro Gly Ser Arg Glu Ser Thr Leu Arg
 280                 285                 290                 295

 cgc cac gcg ggc ggc ctg ggg ctg gcg gag cgc gag gcg gag gcg gag     2706
 Arg His Ala Gly Gly Leu Gly Leu Ala Glu Arg Glu Ala Glu Ala Glu
                 300                 305                 310

 gcc gag ggc tac ttc cgc aag atg cag gcg cgc cgc ttc ccc gac tag     2754
 Ala Glu Gly Tyr Phe Arg Lys Met Gln Ala Arg Arg Phe Pro Asp 
             315                 320                 325





      <210> 656
      <211> 1796
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (139)..(1239)

      <400> 656
 gctgagttcg gcagctcaca cagcacccct ttcaagttgt tttgcagtgg gtgcctcttg     60

 tgagacactg tttctgagag cagcttttgt ggcatcttac agggcagatt tctggtccca    120

 cccacctctg cctccgcc  atg gct gca aga acc gtt atc att gac cac ggg     171
                      Met Ala Ala Arg Thr Val Ile Ile Asp His Gly
                        1               5                  10

 tct ggc ttt ttg aag gct ggc acg gcc ggc tgg aat gag cct cag atg      219
 Ser Gly Phe Leu Lys Ala Gly Thr Ala Gly Trp Asn Glu Pro Gln Met
              15                  20                  25

 gtc ttc ccg aac atc gtg aac tac cta ccg tgc aag gag aac cct ggc      267
 Val Phe Pro Asn Ile Val Asn Tyr Leu Pro Cys Lys Glu Asn Pro Gly
          30                  35                  40

 ccc agc tat gcc cgt agg cgt gtg agc ctg ggc atc gac att tgc cat      315
 Pro Ser Tyr Ala Arg Arg Arg Val Ser Leu Gly Ile Asp Ile Cys His
      45                  50                  55

 cct gac acc ttt agc tac ccc atc gag cgg ggc cgc atc ctc aac tgg      363
 Pro Asp Thr Phe Ser Tyr Pro Ile Glu Arg Gly Arg Ile Leu Asn Trp
  60                  65                  70                  75

 gag ggt gtg cag tac ctc tgg tca ttt gtg ttg gag aac cac aga cgg      411
 Glu Gly Val Gln Tyr Leu Trp Ser Phe Val Leu Glu Asn His Arg Arg
                  80                  85                  90

 gag caa gag gtc ccc cct gtg atc atc acg gag aca ccc ttg agg gag      459
 Glu Gln Glu Val Pro Pro Val Ile Ile Thr Glu Thr Pro Leu Arg Glu
              95                 100                 105

 cct gcg gac cga aag aag atg ctg gag atc ctg ttt gag ttg ctg cat      507
 Pro Ala Asp Arg Lys Lys Met Leu Glu Ile Leu Phe Glu Leu Leu His
         110                 115                 120

 gtc cca tcg gtc ctc ctg gcc gac cag ctg cag atg tcc ctg tat gcc      555
 Val Pro Ser Val Leu Leu Ala Asp Gln Leu Gln Met Ser Leu Tyr Ala
     125                 130                 135

 tct ggc ctc ctg acc gga gtg gtg gtt gat tct ggc tat ggc ctg acc      603
 Ser Gly Leu Leu Thr Gly Val Val Val Asp Ser Gly Tyr Gly Leu Thr
 140                 145                 150                 155

 cgc gtg cag cct ttc cac cag ggc cgc ccc ttg ccc gcc agc ggc aag      651
 Arg Val Gln Pro Phe His Gln Gly Arg Pro Leu Pro Ala Ser Gly Lys
                 160                 165                 170

 acg ctg gag ttc gcc ggc cag gat ctc tcc gcc tat ctc ctc aag agt      699
 Thr Leu Glu Phe Ala Gly Gln Asp Leu Ser Ala Tyr Leu Leu Lys Ser
             175                 180                 185

 ctc ttt aag gaa gat tgc gat aga cgc tgc ctg ttt cag ctg gag aca      747
 Leu Phe Lys Glu Asp Cys Asp Arg Arg Cys Leu Phe Gln Leu Glu Thr
         190                 195                 200

 gtc gcc gtg act cag atg aac aag tgc tac gtg ccg cag aat ctg ggg      795
 Val Ala Val Thr Gln Met Asn Lys Cys Tyr Val Pro Gln Asn Leu Gly
     205                 210                 215

 gag gcc ctg gac ttt cgt gag agg cag cag agt gcc ttg gat gag agc      843
 Glu Ala Leu Asp Phe Arg Glu Arg Gln Gln Ser Ala Leu Asp Glu Ser
 220                 225                 230                 235

 aac acc tat cag ctc cca gac ggc tcc cgc gtg gag ctg acc ccc atg      891
 Asn Thr Tyr Gln Leu Pro Asp Gly Ser Arg Val Glu Leu Thr Pro Met
                 240                 245                 250

 cag cgg gtg gct cct gag atg ttc ttt agc ccg cag gtg ttc gag cag      939
 Gln Arg Val Ala Pro Glu Met Phe Phe Ser Pro Gln Val Phe Glu Gln
             255                 260                 265

 ccg ggg ccc agc atc cca cgg gcc att gtg gaa tcc gtg gag tcc tgc      987
 Pro Gly Pro Ser Ile Pro Arg Ala Ile Val Glu Ser Val Glu Ser Cys
         270                 275                 280

 gag atc tcc ctg cgc ccc ctg ctg gtc tcc cac gtg atg gcc tgc ggg     1035
 Glu Ile Ser Leu Arg Pro Leu Leu Val Ser His Val Met Ala Cys Gly
     285                 290                 295

 ggc aac acc ctc tat ccc ggg ttc aca aag cgc ctg ttc agg gag ctg     1083
 Gly Asn Thr Leu Tyr Pro Gly Phe Thr Lys Arg Leu Phe Arg Glu Leu
 300                 305                 310                 315

 atg ggg gat cac gtc tcc tcc acc aag gcc aca gtc tgg gag ggt tcc     1131
 Met Gly Asp His Val Ser Ser Thr Lys Ala Thr Val Trp Glu Gly Ser
                 320                 325                 330

 aat aga aac ttt agt gtc tgg cta gga gcg tcc gtg gtg gct cac ctt     1179
 Asn Arg Asn Phe Ser Val Trp Leu Gly Ala Ser Val Val Ala His Leu
             335                 340                 345

 tct acc tac cag tct gag tgg atg tcc cga gag gag tat ggt gag cat     1227
 Ser Thr Tyr Gln Ser Glu Trp Met Ser Arg Glu Glu Tyr Gly Glu His
         350                 355                 360

 atg agg atg tga ccc tactggctca ctcctgagaa tgggctcctg ttagatgggc     1282
 Met Arg Met 
     365

 acgggcggat taattttagc aaaatgttct gggtgggggt agaatgaggt ggggtggggt   1342

 gagctggctt tggaattcta ggggcatgag ggtatttttt aggttctaag gttttatctt   1402

 gttgcaagag tgggacctac ccaaggggga agacaagatg tcatccttgg aaaccctgca   1462

 ggggacagtt tttccagggt ggcctatcat tggggtatga gtggctgact gccatctcca   1522

 tgcctgagag ccactgattt ttcattggca tttcccctgg tttgtctcat tcttcttggt   1582

 tgagtaggtt ttaactgggg tagcactcct gctaggagtc ccaattattt ttgactaggg   1642

 gatgggggac agttgacatt tctggtccta caggcccttt ctggccaggg aggcattgct   1702

 gcaggtgagc ctgggatgcc cttgccaccc gtggttggat cttgttttat atctgcaaat   1762

 aaatagcttg tttggaagca aaaaaaaaaa aaaa                               1796




      <210> 657
      <211> 1879
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (445)..(1737)

      <400> 657
 cctattggtt ttggattgga aaagttattg acatttcatc tctcccaatt gcaagaatat     60

 agaggaacca agtggaggga aaaatcccac aggaaagtca accatgatga gaacacaagg    120

 ggcctagctg cggagccccg cgcccgagag cggcgggtaa ggagccgcgg gagccggcga    180

 ggcgtcgggg cgcgcagagg agcgcccctg cccgggcacc cgctgggcca cgggactcgc    240

 gtgtggcctg agcgccgggg aggaggcgga ggcgcccctc tgtccgggct ctgggaaggc    300

 gacgaggggc tctgcgaagg cggcgagggg ctccgcggcg gccccggacc cctggccacc    360

 atcctcacgc tcctgctccc gccgggggga tgtcgtggcc cgggccccga gcgccgcccc    420

 ggccccgggg ctgagctccg gacc   atg tcc tcc cgc agc ccc cgg ccc ccg     471
                              Met Ser Ser Arg Ser Pro Arg Pro Pro
                                1               5

 ccc cgc cgt agc cgc cgc cgc ctg ccg cgc ccc tcc tgc tgc tgc tgc      519
 Pro Arg Arg Ser Arg Arg Arg Leu Pro Arg Pro Ser Cys Cys Cys Cys
  10                  15                  20                  25

 tgc tgc cgc cgt tcg cac ctc aac gag gac acc ggc cgc ttc gtg ctg      567
 Cys Cys Arg Arg Ser His Leu Asn Glu Asp Thr Gly Arg Phe Val Leu
                  30                  35                  40

 ctg gcg gcg ctc atc ggc ctc tac ctg gtg gcg ggt gcc aca gtc ttc      615
 Leu Ala Ala Leu Ile Gly Leu Tyr Leu Val Ala Gly Ala Thr Val Phe
              45                  50                  55

 tcg gcg ctc gag agc ccc ggc gag gcg gag gcg cgg gcg cgc tgg ggc      663
 Ser Ala Leu Glu Ser Pro Gly Glu Ala Glu Ala Arg Ala Arg Trp Gly
          60                  65                  70

 gcc acg ctg cgc aac ttc agc gct gcg cac ggc gtg gcc gag cca gag      711
 Ala Thr Leu Arg Asn Phe Ser Ala Ala His Gly Val Ala Glu Pro Glu
      75                  80                  85

 ctg cgc gcc ttc ctc cgg cac tac gag gcc gcg ctg gcc gcc ggc gtc      759
 Leu Arg Ala Phe Leu Arg His Tyr Glu Ala Ala Leu Ala Ala Gly Val
  90                  95                 100                 105

 cgc gcc gac gcg ctg cgc ccg cgc tgg gac ttc ccc ggc gcc ttc tac      807
 Arg Ala Asp Ala Leu Arg Pro Arg Trp Asp Phe Pro Gly Ala Phe Tyr
                 110                 115                 120

 ttc gtg ggc acc gtg gtg tca acc ata ggt ttc ggc atg acc acc ccc      855
 Phe Val Gly Thr Val Val Ser Thr Ile Gly Phe Gly Met Thr Thr Pro
             125                 130                 135

 gcg acg gtg ggc ggg aag gcc ttc ctc atc gcc tac ggg ctg ttc ggc      903
 Ala Thr Val Gly Gly Lys Ala Phe Leu Ile Ala Tyr Gly Leu Phe Gly
         140                 145                 150

 tgc gct ggg acc atc ctg ttc ttc aac ctc ttc ctg gag cgc atc atc      951
 Cys Ala Gly Thr Ile Leu Phe Phe Asn Leu Phe Leu Glu Arg Ile Ile
     155                 160                 165

 tcg ctg ctg gcc ttc atc atg cgc gcc tgc cgg gag cgc cag ctg cgc      999
 Ser Leu Leu Ala Phe Ile Met Arg Ala Cys Arg Glu Arg Gln Leu Arg
 170                 175                 180                 185

 cgc agc ggc ctg ctg ccc gcc acc ttc cgc cgc ggc tcc gcg ctc tcg     1047
 Arg Ser Gly Leu Leu Pro Ala Thr Phe Arg Arg Gly Ser Ala Leu Ser
                 190                 195                 200

 gag gcc gac agc ctg gcg ggc tgg aag ccc tcg gtg tac cac gtg ctg     1095
 Glu Ala Asp Ser Leu Ala Gly Trp Lys Pro Ser Val Tyr His Val Leu
             205                 210                 215

 ctc atc ctg ggc ctg ttc gcc gtg ctg ctg tcc tgc tgc gcc tcg gcc     1143
 Leu Ile Leu Gly Leu Phe Ala Val Leu Leu Ser Cys Cys Ala Ser Ala
         220                 225                 230

 atg tac acc agc gtg gag ggc tgg gac tac gtg gac tcg ctc tac ttc     1191
 Met Tyr Thr Ser Val Glu Gly Trp Asp Tyr Val Asp Ser Leu Tyr Phe
     235                 240                 245

 tgc ttc gtc acc ttc agc acc atc ggc ttc ggg gac ctg gtg agc agc     1239
 Cys Phe Val Thr Phe Ser Thr Ile Gly Phe Gly Asp Leu Val Ser Ser
 250                 255                 260                 265

 cag cac gcc gcc tac cgg aac cag ggg ctc tac cgc ctg ggc aac ttc     1287
 Gln His Ala Ala Tyr Arg Asn Gln Gly Leu Tyr Arg Leu Gly Asn Phe
                 270                 275                 280

 ctc ttc atc ctg ctc ggc gtg tgc tgc att tac tcg ctc ttc aac gtc     1335
 Leu Phe Ile Leu Leu Gly Val Cys Cys Ile Tyr Ser Leu Phe Asn Val
             285                 290                 295

 atc tcc atc ctc atc aag cag gtg ctc aac tgg atg ctg cgc aag ctg     1383
 Ile Ser Ile Leu Ile Lys Gln Val Leu Asn Trp Met Leu Arg Lys Leu
         300                 305                 310

 agc tgc cgc tgc tgc gcg cgc tgc tgc ccg gct cct ggc gcg ccc ctg     1431
 Ser Cys Arg Cys Cys Ala Arg Cys Cys Pro Ala Pro Gly Ala Pro Leu
     315                 320                 325

 gcc cgg cgc aat gcc atc acc cca ggc tcc cgg ctg cgc cgc cgc ctg     1479
 Ala Arg Arg Asn Ala Ile Thr Pro Gly Ser Arg Leu Arg Arg Arg Leu
 330                 335                 340                 345

 gcc gcg ctc ggt gcc gac ccc gcg gcc cgc gac agc gac gcc gag ggc     1527
 Ala Ala Leu Gly Ala Asp Pro Ala Ala Arg Asp Ser Asp Ala Glu Gly
                 350                 355                 360

 cgc cgc ctc tcg ggc gag ctc atc tcc atg cgc gac ctc acg gcc tcc     1575
 Arg Arg Leu Ser Gly Glu Leu Ile Ser Met Arg Asp Leu Thr Ala Ser
             365                 370                 375

 aac aag gtg tcg ctg gcg ctg ctg cag aag cag ctg tcg gag acg gcc     1623
 Asn Lys Val Ser Leu Ala Leu Leu Gln Lys Gln Leu Ser Glu Thr Ala
         380                 385                 390

 aac ggc tac ccg cgc agc gtg tgc gtc aac acg cgc cag aac ggc ttc     1671
 Asn Gly Tyr Pro Arg Ser Val Cys Val Asn Thr Arg Gln Asn Gly Phe
     395                 400                 405

 tcg ggc ggc gtg ggc gcg ctg ggc atc atg aac aac cgg ctg gcc gag     1719
 Ser Gly Gly Val Gly Ala Leu Gly Ile Met Asn Asn Arg Leu Ala Glu
 410                 415                 420                 425

 acc agc gcc tcc agg tag accgcc cgtccgcccg cgccggggac cctctccagg     1773
 Thr Ser Ala Ser Arg 
                 430

 ccgcggggcc gccgggcgtg gtttgcttct ctcagtcact gctggcgctt tcttaatctt   1833

 tatccaataa aatgaaacaa aaaaaatttt tttaaaaaaa aaaaaa                  1879




      <210> 658
      <211> 1411
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (660)..(1367)

      <400> 658
 accccacccc ccatcccttc accccactgg ggctcatcgc tcaggctgta ggagggaaat     60

 ggaaggatgt ctcccgggct ctgctggcgc tggtgtccga gtcacggcgc ccccagcagt    120

 ctccccgagg cagagtcatg ggggtctggc gcctggacgc tgtctcatcc cgggagccgc    180

 tttcccaccg gctccctggg ctccagccgc cccacgcgag cccccggctg gttatggggc    240

 caggaccgcc cctctccaag gcagacttcc cttcattcca cgacaaagac gcgcaccccg    300

 tttccctggc tctagccggc agggctgcct gtccccttcc gcgggtcgcc agcagccagc    360

 acaggccgca aacgcggtcc gcagacggac caacggagcc gaccctcgca ggcttggagc    420

 cggacgcggc gggcagagcc cccgagctgc agctcgccgg aacccgcggg agggcagccg    480

 ggctgggcgg acgcacagcc cacggaccga ccgcgcaggc tctgccggcc acttccggtg    540

 tcgcgcggcg gctcccggca ggaggcagag ggcacaccgc cagccccagg ccaggctgcg    600

 agggccgcgg acccgagccg ggaaggacct tgggcggacg agccgcgcgt cccgcagcc     659                                                                 
 atg gag cag gac gac ccg gtc gag gcg ctg acg gag ctg cgc gag cgg      707
 Met Glu Gln Asp Asp Pro Val Glu Ala Leu Thr Glu Leu Arg Glu Arg
   1               5                  10                  15

 cgg ctg ggc gcg ctg gag ctg ctg cag gcg gcg gcc ggc tcg ggc ttg      755
 Arg Leu Gly Ala Leu Glu Leu Leu Gln Ala Ala Ala Gly Ser Gly Leu
              20                  25                  30

 gca gcc tac gcg gtg tgg gcg ctg ctg ctc cag ccc ggc ttc cgg cgc      803
 Ala Ala Tyr Ala Val Trp Ala Leu Leu Leu Gln Pro Gly Phe Arg Arg
          35                  40                  45

 gtg ccg ctg cgg ctg cag gtg ccc tac gtc ggc gcg agc gcg cgg cag      851
 Val Pro Leu Arg Leu Gln Val Pro Tyr Val Gly Ala Ser Ala Arg Gln
      50                  55                  60

 gtg gag cac gtg ttg tcg ctg ctg cga gga cgc ccc gga aaa acg gtg      899
 Val Glu His Val Leu Ser Leu Leu Arg Gly Arg Pro Gly Lys Thr Val
  65                  70                  75                  80

 gat ctg ggc tct ggc gac ggc agg atc gtg ctg gcg gcc cac agg tgc      947
 Asp Leu Gly Ser Gly Asp Gly Arg Ile Val Leu Ala Ala His Arg Cys
                  85                  90                  95

 ggc ctc cgc ccg gcc gtg ggc tac gag ctg aac ccc tgg ctg gtg gcg      995
 Gly Leu Arg Pro Ala Val Gly Tyr Glu Leu Asn Pro Trp Leu Val Ala
             100                 105                 110

 ctg gcg cgg ctg cac gcc tgg agg gcc ggc tgt gcc ggc agc gtc tgc     1043
 Leu Ala Arg Leu His Ala Trp Arg Ala Gly Cys Ala Gly Ser Val Cys
         115                 120                 125

 tat cgc cgc aag gat ctc tgg aag gtg agc ctg agg gac tgc cgc aac     1091
 Tyr Arg Arg Lys Asp Leu Trp Lys Val Ser Leu Arg Asp Cys Arg Asn
     130                 135                 140

 gtg tct gtg ttc ctg gcc cct agc gtg ctc ccg ctg ctg gag gac aag     1139
 Val Ser Val Phe Leu Ala Pro Ser Val Leu Pro Leu Leu Glu Asp Lys
 145                 150                 155                 160

 ctg cgg aca gag ctg cct gct ggg gcc cgc gtg gtg tct ggg cgc ttc     1187
 Leu Arg Thr Glu Leu Pro Ala Gly Ala Arg Val Val Ser Gly Arg Phe
                 165                 170                 175

 cca ctc ccc acc tgg cag cct gtg acc gcg gtt ggc gag ggc ctg gac     1235
 Pro Leu Pro Thr Trp Gln Pro Val Thr Ala Val Gly Glu Gly Leu Asp
             180                 185                 190

 cga gta tgg gct tat gat gtt cct gag ggt ggg cag gct ggg gag gcc     1283
 Arg Val Trp Ala Tyr Asp Val Pro Glu Gly Gly Gln Ala Gly Glu Ala
         195                 200                 205

 gcc tcc tcg cgg ata ccc atc cag gct gcc ccc gga cct agt tct gcc     1331
 Ala Ser Ser Arg Ile Pro Ile Gln Ala Ala Pro Gly Pro Ser Ser Ala
     210                 215                 220

 ccc atc ccg ggg ggc ctt att tct cag gcc agc tga gtat tagacacgat     1381
 Pro Ile Pro Gly Gly Leu Ile Ser Gln Ala Ser 
 225                 230                 235

 aaagactctg tgggttctaa aaaaaaaaaa                                    1411




      <210> 659
      <211> 2022
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2022)

      <400> 659
  atg tgg ttt gtt gag ttc att caa gta aac ctt tat cga gtg cct gtt      48
  Met Trp Phe Val Glu Phe Ile Gln Val Asn Leu Tyr Arg Val Pro Val
    1               5                  10                  15

 gta tgc agg gca ctg ttc tgg ctg tta gca aca cag aca agt aag aca       96
 Val Cys Arg Ala Leu Phe Trp Leu Leu Ala Thr Gln Thr Ser Lys Thr
              20                  25                  30

 tgt tct ctg aac tca agg aat tta caa tct ctg gta aaa gtg att ggg      144
 Cys Ser Leu Asn Ser Arg Asn Leu Gln Ser Leu Val Lys Val Ile Gly
          35                  40                  45

 gac ctg aat aat tgt agg gaa tgg tta aaa cca gtt act aat gag att      192
 Asp Leu Asn Asn Cys Arg Glu Trp Leu Lys Pro Val Thr Asn Glu Ile
      50                  55                  60

 aat aag aga gtt cct gaa aag cag ttt agg gca ctg gtt agc aag aaa      240
 Asn Lys Arg Val Pro Glu Lys Gln Phe Arg Ala Leu Val Ser Lys Lys
  65                  70                  75                  80

 atc aag cat cca ttg atc ata agt gat gtt tac cca aag agt gag aag      288
 Ile Lys His Pro Leu Ile Ile Ser Asp Val Tyr Pro Lys Ser Glu Lys
                  85                  90                  95

 tta aaa gaa cta aaa agg cag ata aaa att aaa act att tct gca ttt      336
 Leu Lys Glu Leu Lys Arg Gln Ile Lys Ile Lys Thr Ile Ser Ala Phe
             100                 105                 110

 gaa gtc cag cca att tcc act gag gtc cac gaa ggt gga gtt gct cga      384
 Glu Val Gln Pro Ile Ser Thr Glu Val His Glu Gly Gly Val Ala Arg
         115                 120                 125

 ttt gca tgc aag att tca tcc cac cct cct gca gtc ata aca tgg gag      432
 Phe Ala Cys Lys Ile Ser Ser His Pro Pro Ala Val Ile Thr Trp Glu
     130                 135                 140

 ttc aat cgg aca act cta cct atg act atg gac agg ata act gcc cta      480
 Phe Asn Arg Thr Thr Leu Pro Met Thr Met Asp Arg Ile Thr Ala Leu
 145                 150                 155                 160

 cca aca gga gta ttg cag atc tat gat gtc agc caa agg gat tct gga      528
 Pro Thr Gly Val Leu Gln Ile Tyr Asp Val Ser Gln Arg Asp Ser Gly
                 165                 170                 175

 aat tat cgt tgt att gct gcc act gta gcc cac cga cgt aaa agt atg      576
 Asn Tyr Arg Cys Ile Ala Ala Thr Val Ala His Arg Arg Lys Ser Met
             180                 185                 190

 gag gcc tcg cta act gtg att cca gct aag gag tca aaa tcc ttc cac      624
 Glu Ala Ser Leu Thr Val Ile Pro Ala Lys Glu Ser Lys Ser Phe His
         195                 200                 205

 aca cca aca att ata gca ggt cca cag aac ata aca aca tct ctt cat      672
 Thr Pro Thr Ile Ile Ala Gly Pro Gln Asn Ile Thr Thr Ser Leu His
     210                 215                 220

 cag act gta gtt ttg gaa tgc atg gcc aca gga aat ccc aaa cca atc      720
 Gln Thr Val Val Leu Glu Cys Met Ala Thr Gly Asn Pro Lys Pro Ile
 225                 230                 235                 240

 att tct tgg agc cgc ctt gat cac aaa tcc att gat gtc ttt aat act      768
 Ile Ser Trp Ser Arg Leu Asp His Lys Ser Ile Asp Val Phe Asn Thr
                 245                 250                 255

 cgg gta ctt gga aat ggt aat ctc atg ata tct gat gtc agg cta caa      816
 Arg Val Leu Gly Asn Gly Asn Leu Met Ile Ser Asp Val Arg Leu Gln
             260                 265                 270

 cat gct gga gta tat gtt tgt cgg gcc act acc cct ggc aca cgc aac      864
 His Ala Gly Val Tyr Val Cys Arg Ala Thr Thr Pro Gly Thr Arg Asn
         275                 280                 285

 ttt aca gtt gct atg gca act tta act gta tta gct cct cct tca ttt      912
 Phe Thr Val Ala Met Ala Thr Leu Thr Val Leu Ala Pro Pro Ser Phe
     290                 295                 300

 gtt gaa tgg cca gaa agt tta aca agg cct cga gct ggc act gct cga      960
 Val Glu Trp Pro Glu Ser Leu Thr Arg Pro Arg Ala Gly Thr Ala Arg
 305                 310                 315                 320

 ttt gtg tgt cag gca gaa gga atc ccc tct ccc aag atg tca tgg ttg     1008
 Phe Val Cys Gln Ala Glu Gly Ile Pro Ser Pro Lys Met Ser Trp Leu
                 325                 330                 335

 aaa aat gga agg aag ata cat tcg aat ggt aga att aaa atg tac aac     1056
 Lys Asn Gly Arg Lys Ile His Ser Asn Gly Arg Ile Lys Met Tyr Asn
             340                 345                 350

 agt aaa ttg gta att aac cag att att cct gaa gat gat gct att tat     1104
 Ser Lys Leu Val Ile Asn Gln Ile Ile Pro Glu Asp Asp Ala Ile Tyr
         355                 360                 365

 cag tgc atg gct gag aat agc caa gga tct att tta tct aga gcc aga     1152
 Gln Cys Met Ala Glu Asn Ser Gln Gly Ser Ile Leu Ser Arg Ala Arg
     370                 375                 380

 ctg act gta gtg atg tca gaa gac aga ccc agt gct ccc tat aat gta     1200
 Leu Thr Val Val Met Ser Glu Asp Arg Pro Ser Ala Pro Tyr Asn Val
 385                 390                 395                 400

 cat gct gaa acc atg tca agc tca gcc att ctt tta gcc tgg gag agg     1248
 His Ala Glu Thr Met Ser Ser Ser Ala Ile Leu Leu Ala Trp Glu Arg
                 405                 410                 415

 cca ctt tat aat tca gac aaa gtc att gcc tat tct gta cac tac atg     1296
 Pro Leu Tyr Asn Ser Asp Lys Val Ile Ala Tyr Ser Val His Tyr Met
             420                 425                 430

 aaa gca gaa ggt tta aat aat gaa gag tat caa gta gtc atc gga aat     1344
 Lys Ala Glu Gly Leu Asn Asn Glu Glu Tyr Gln Val Val Ile Gly Asn
         435                 440                 445

 gac aca act cat tat att att gat gac tta gag cct gcc agc aat tat     1392
 Asp Thr Thr His Tyr Ile Ile Asp Asp Leu Glu Pro Ala Ser Asn Tyr
     450                 455                 460

 act ttc tac att gta gca tat atg cca atg gga gcc agc cag atg tct     1440
 Thr Phe Tyr Ile Val Ala Tyr Met Pro Met Gly Ala Ser Gln Met Ser
 465                 470                 475                 480

 gac cat gtg aca cag aat act cta gag gat gtt ccc ctg aga cct cct     1488
 Asp His Val Thr Gln Asn Thr Leu Glu Asp Val Pro Leu Arg Pro Pro
                 485                 490                 495

 gaa att agt ttg aca agt cga agt ccc act gat att ctc atc tcc tgg     1536
 Glu Ile Ser Leu Thr Ser Arg Ser Pro Thr Asp Ile Leu Ile Ser Trp
             500                 505                 510

 ctg cca atc cca gcc aaa tat cgg cgg ggc caa gtg gtg ctg tat cgc     1584
 Leu Pro Ile Pro Ala Lys Tyr Arg Arg Gly Gln Val Val Leu Tyr Arg
         515                 520                 525

 ttg tct ttc cgc cta agt act gag aat tca atc caa gtt ctg gag ctc     1632
 Leu Ser Phe Arg Leu Ser Thr Glu Asn Ser Ile Gln Val Leu Glu Leu
     530                 535                 540

 ccg ggg acc acg cat gag tac ctt ttg gaa ggc ctg aaa cct gac agt     1680
 Pro Gly Thr Thr His Glu Tyr Leu Leu Glu Gly Leu Lys Pro Asp Ser
 545                 550                 555                 560

 gtc tac ctg gtt cgg att act gct gcc acc aga gtg ggg ctg gga gag     1728
 Val Tyr Leu Val Arg Ile Thr Ala Ala Thr Arg Val Gly Leu Gly Glu
                 565                 570                 575

 tca tca gta tgg act tca cat agg acg ccc aaa gct aca agc gtg aaa     1776
 Ser Ser Val Trp Thr Ser His Arg Thr Pro Lys Ala Thr Ser Val Lys
             580                 585                 590

 gcc aag tct cca gag ttg cat ttg gag cct ctg aac tgt acc acc att     1824
 Ala Lys Ser Pro Glu Leu His Leu Glu Pro Leu Asn Cys Thr Thr Ile
         595                 600                 605

 tct gtg agg tgg cag caa gat gta gag gac aca gct gct att cag ggc     1872
 Ser Val Arg Trp Gln Gln Asp Val Glu Asp Thr Ala Ala Ile Gln Gly
     610                 615                 620

 tac aag ctg tac tac aag gaa gaa ggg cag cag gag aat ggg ccc att     1920
 Tyr Lys Leu Tyr Tyr Lys Glu Glu Gly Gln Gln Glu Asn Gly Pro Ile
 625                 630                 635                 640

 ttc ttg gat acc aag gac cta ctc tat act ctc agt ggc tta gac tgc     1968
 Phe Leu Asp Thr Lys Asp Leu Leu Tyr Thr Leu Ser Gly Leu Asp Cys
                 645                 650                 655

 cct gtg aag gaa cta gag cag ctg cct cag ctg agt gtt aca gtg aca     2016
 Pro Val Lys Glu Leu Glu Gln Leu Pro Gln Leu Ser Val Thr Val Thr
             660                 665                 670

 tct tag                                                             2022
 Ser 






      <210> 660
      <211> 3386
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (169)..(3081)

      <400> 660
 ggtcgccgcc acctccgcct cttcagtctc ctggtcttcg tcgccgctct ctctctcacc     60

 tctcagggaa agggggggac ataggggcgt cgcggggccc cggcgaatgc gccccccgcc    120

 gcctctcggg ctgcgccgcc tcgcggggat gaagcaccgg ccgtgaag atg gag gtg     177
                                                      Met Glu Val
                                                        1

 acc tgc ctt cta ctt ctg gcg ctg atc ccc ttc cac tgc cgg gga caa      225
 Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys Arg Gly Gln
       5                  10                  15

 gga gtc tac gct cca gcc cag gcg cag atc gtg cat gcg ggc cag gca      273
 Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala Gly Gln Ala
  20                  25                  30                  35

 tgt gtg gtg aaa gag gac aat atc agc gag cgt gtc tac acc atc cgg      321
 Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr Thr Ile Arg
                  40                  45                  50

 gag ggg gac acc ctc atg ctg cag tgc ctt gta aca ggg cac cct cga      369
 Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly His Pro Arg
              55                  60                  65

 ccc cag gta cgg tgg acc aag acg gca ggt agc gcc tcg gac aag ttc      417
 Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser Asp Lys Phe
          70                  75                  80

 cag gag aca tcg gtg ttc aac gag acg ctg cgc atc gag cgt att gca      465
 Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu Arg Ile Ala
      85                  90                  95

 cgc acg cag ggc ggc cgc tac tac tgc aag gct gag aac ggc gtg ggg      513
 Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn Gly Val Gly
 100                 105                 110                 115

 gtg ccg gcc atc aag tcc atc cgc gtg gac gtg cag tac ctg gat gag      561
 Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr Leu Asp Glu
                 120                 125                 130

 cca atg ctg acg gtg cac cag acg gtg agc gat gtg cga ggc aac ttc      609
 Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg Gly Asn Phe
             135                 140                 145

 tac cag gag aag acg gtg ttc ctg cgc tgt act gtc aac tcc aac cca      657
 Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn Ser Asn Pro
         150                 155                 160

 cct gcc cgc ttc atc tgg aag cgg ggt tcc gat acc cta tcc cac agc      705
 Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu Ser His Ser
     165                 170                 175

 cag gac aat ggg gtt gac atc tat gag ccc ctc tac act cag ggg gag      753
 Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr Gln Gly Glu
 180                 185                 190                 195

 acc aag gtc ctg aag ctg aag aac ctg cgg ccc cag gac tat gcc agc      801
 Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp Tyr Ala Ser
                 200                 205                 210

 tac acc tgc cag gtg tct gtg cgt aac gtg tgc ggc atc cca gac aag      849
 Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile Pro Asp Lys
             215                 220                 225

 gcc atc acc ttc cgg ctc acc aac acc acg gca cca cca gcc ctg aag      897
 Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro Ala Leu Lys
         230                 235                 240

 ctg tct gtg aac gaa act ctg gtg gtg aac cct ggg gag aat gtg acg      945
 Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu Asn Val Thr
     245                 250                 255

 gtg cag tgt ctg ctg aca ggc ggt gat ccc ctc ccc cag ctg cag tgg      993
 Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln Leu Gln Trp
 260                 265                 270                 275

 tcc cat ggg cct ggc cca ctg ccc ctg ggt gct ctg gcc cag ggt ggc     1041
 Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala Gln Gly Gly
                 280                 285                 290

 acc ctc agc atc cct tca gtg cag gcc cgg gac tct ggc tac tac aac     1089
 Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly Tyr Tyr Asn
             295                 300                 305

 tgc aca gcc acc aac aat gtg ggc aac cct gcc aag aag act gtc aac     1137
 Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys Thr Val Asn
         310                 315                 320

 ctg ctg gtg cga tcc atg aag aac gct aca ttc cag atc act cct gac     1185
 Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile Thr Pro Asp
     325                 330                 335

 gtg atc aaa gag agt gag aac atc cag ctg ggc cag gac ctg aag cta     1233
 Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp Leu Lys Leu
 340                 345                 350                 355

 tcg tgc cac gtg gat gca gtg ccc cag gag aag gtg acc tac cag tgg     1281
 Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr Tyr Gln Trp
                 360                 365                 370

 ttc aag aat ggc aag ccg gca cgc atg tcc aag cgg ctg ctg gtg acc     1329
 Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu Leu Val Thr
             375                 380                 385

 cgc aat gat cct gag ctg ccc gca gtc acc agc agc cta gag ctc att     1377
 Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu Glu Leu Ile
         390                 395                 400

 gac ctg cac ttc agt gac tat ggc acc tac ctg tgc atg gct tct ttc     1425
 Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met Ala Ser Phe
     405                 410                 415

 cca ggg gca ccc gtg ccc gac ctc agc gtc gag gtc aac atc tcc tct     1473
 Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn Ile Ser Ser
 420                 425                 430                 435

 gag aca gtg ccg ccc acc atc agt gtg ccc aag ggt agg gcc gtg gtg     1521
 Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg Ala Val Val
                 440                 445                 450

 acc gtg cgc gag gga tcg cct gcc gag ctg caa tgc gag gtg cgg ggc     1569
 Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu Val Arg Gly
             455                 460                 465

 aag ccg cgg ccg cca gtg ctc tgg tcc cgc gtg gac aag gag gct gca     1617
 Lys Pro Arg Pro Pro Val Leu Trp Ser Arg Val Asp Lys Glu Ala Ala
         470                 475                 480

 ctg ctg ccc tcg ggg ctg ccc ctg gag gag act ccg gac ggg aag ctg     1665
 Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu Thr Pro Asp Gly Lys Leu
     485                 490                 495

 cgg ctg gag cga gtg agc cga gac atg agc ggg acc tac cgc tgc cag     1713
 Arg Leu Glu Arg Val Ser Arg Asp Met Ser Gly Thr Tyr Arg Cys Gln
 500                 505                 510                 515

 acg gcc cgc tat aat ggc ttc aac gtg cgc ccc cgt gag gcc cag gtg     1761
 Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg Pro Arg Glu Ala Gln Val
                 520                 525                 530

 cag ctg aac gtg cag ttc ccg ccg gag gtg gag ccc agt tcc cag gac     1809
 Gln Leu Asn Val Gln Phe Pro Pro Glu Val Glu Pro Ser Ser Gln Asp
             535                 540                 545

 gtg cgc cag gcg ctg ggc cgg ccc gtg ctc ctg cgc tgc tcg ctg ctg     1857
 Val Arg Gln Ala Leu Gly Arg Pro Val Leu Leu Arg Cys Ser Leu Leu
         550                 555                 560

 cga ggc agc ccc cag cgc atc gcc tcg gct gtg tgg cgt ttc aaa ggg     1905
 Arg Gly Ser Pro Gln Arg Ile Ala Ser Ala Val Trp Arg Phe Lys Gly
     565                 570                 575

 cag ctg ctg ccg ccg ccg cct gtt gtt ccc gcc gcc gcc gag gcg ccg     1953
 Gln Leu Leu Pro Pro Pro Pro Val Val Pro Ala Ala Ala Glu Ala Pro
 580                 585                 590                 595

 gat cac gcg gag ctg cgc ctc gac gcc gta act cgc gac agc agc ggc     2001
 Asp His Ala Glu Leu Arg Leu Asp Ala Val Thr Arg Asp Ser Ser Gly
                 600                 605                 610

 agc tac gag tgc agc gtc tcc aac gat gtg ggc tcg gct gcc tgc ctc     2049
 Ser Tyr Glu Cys Ser Val Ser Asn Asp Val Gly Ser Ala Ala Cys Leu
             615                 620                 625

 ttc cag gtc tcc gcc aaa gcc tac agc ccg gag ttt tac ttc gac acc     2097
 Phe Gln Val Ser Ala Lys Ala Tyr Ser Pro Glu Phe Tyr Phe Asp Thr
         630                 635                 640

 ccc aac ccc acc cgc agc cac aag ctg tcc aag aac tac tcc tac gtg     2145
 Pro Asn Pro Thr Arg Ser His Lys Leu Ser Lys Asn Tyr Ser Tyr Val
     645                 650                 655

 ctg cag tgg act cag agg gag ccc gac gct gtc gac cct gtg ctc aac     2193
 Leu Gln Trp Thr Gln Arg Glu Pro Asp Ala Val Asp Pro Val Leu Asn
 660                 665                 670                 675

 tac aga ctc agc atc cgc cag ttg aac cag cac aat gcg gtg gtc aag     2241
 Tyr Arg Leu Ser Ile Arg Gln Leu Asn Gln His Asn Ala Val Val Lys
                 680                 685                 690

 gcc atc ccg gtc cgg cgt gtg gag aag ggg cag ctg ctg gag tac atc     2289
 Ala Ile Pro Val Arg Arg Val Glu Lys Gly Gln Leu Leu Glu Tyr Ile
             695                 700                 705

 ctg acc gat ctc cgt gtg ccc cac agc tat gag gtc cgc ctc aca ccc     2337
 Leu Thr Asp Leu Arg Val Pro His Ser Tyr Glu Val Arg Leu Thr Pro
         710                 715                 720

 tat acc acc ttc ggg gct ggt gac atg gcc tcc cgc atc atc cac tac     2385
 Tyr Thr Thr Phe Gly Ala Gly Asp Met Ala Ser Arg Ile Ile His Tyr
     725                 730                 735

 aca gag ccc atc aac tct ccg aac ctt tca gac aac acc tgc cac ttt     2433
 Thr Glu Pro Ile Asn Ser Pro Asn Leu Ser Asp Asn Thr Cys His Phe
 740                 745                 750                 755

 gag gat gag aag atc tgt ggc tat acc cag gac ctg aca gac aac ttt     2481
 Glu Asp Glu Lys Ile Cys Gly Tyr Thr Gln Asp Leu Thr Asp Asn Phe
                 760                 765                 770

 gac tgg acg cgg cag aat gcc ctc acc cag aac ccc aaa cgc tcc ccc     2529
 Asp Trp Thr Arg Gln Asn Ala Leu Thr Gln Asn Pro Lys Arg Ser Pro
             775                 780                 785

 aac act ggt ccc ccc acc gac ata agt ggc acc cct gag ggc tac tac     2577
 Asn Thr Gly Pro Pro Thr Asp Ile Ser Gly Thr Pro Glu Gly Tyr Tyr
         790                 795                 800

 atg ttc atc gag aca tcg agg cct cgg gag ctg ggg gac cgt gca agg     2625
 Met Phe Ile Glu Thr Ser Arg Pro Arg Glu Leu Gly Asp Arg Ala Arg
     805                 810                 815

 tta gtg agt ccc ctc tac aat gcc agc gcc aag ttc tac tgt gtc tcc     2673
 Leu Val Ser Pro Leu Tyr Asn Ala Ser Ala Lys Phe Tyr Cys Val Ser
 820                 825                 830                 835

 ttc ttc tac cac atg tac ggg aaa cac atc ggc tcc ctc aac ctc ctg     2721
 Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu Asn Leu Leu
                 840                 845                 850

 gtg cgg tcc cgg aac aaa ggg gct ctg gac acg cac gcc tgg tct ctc     2769
 Val Arg Ser Arg Asn Lys Gly Ala Leu Asp Thr His Ala Trp Ser Leu
             855                 860                 865

 agt ggc aat aag ggc aat gtg tgg cag cag gcc cat gtg ccc atc agc     2817
 Ser Gly Asn Lys Gly Asn Val Trp Gln Gln Ala His Val Pro Ile Ser
         870                 875                 880

 ccc agt ggg ccc ttc cag att att ttt gag ggg gtt cga ggc ccg ggc     2865
 Pro Ser Gly Pro Phe Gln Ile Ile Phe Glu Gly Val Arg Gly Pro Gly
     885                 890                 895

 tac ctg ggg gat att gcc ata gat gac gtc aca ctg aag aag ggg gag     2913
 Tyr Leu Gly Asp Ile Ala Ile Asp Asp Val Thr Leu Lys Lys Gly Glu
 900                 905                 910                 915

 tgt ccc cgg aag cag acg gat ccc aat aaa ggt gca aga cgg gaa gga     2961
 Cys Pro Arg Lys Gln Thr Asp Pro Asn Lys Gly Ala Arg Arg Glu Gly
                 920                 925                 930

 ggt ggg gga gct gaa tct gga ggg agc tgt gcg tgg cgg ggg ttc ctg     3009
 Gly Gly Gly Ala Glu Ser Gly Gly Ser Cys Ala Trp Arg Gly Phe Leu
             935                 940                 945

 tct gtt gag gga ggg tgt tcg ggt ctg aat agg ggt tca gac tgt ctg     3057
 Ser Val Glu Gly Gly Cys Ser Gly Leu Asn Arg Gly Ser Asp Cys Leu
         950                 955                 960

 atg atg gga atc agg tgg ctc tga ctgtgttaac gtgtgcccac aactcacgtc    3111
 Met Met Gly Ile Arg Trp Leu 
     965                 970

 aggctgagaa ctggtgtaac accatgagaa agcttggccc ccaccatcgt gatgagcata   3171

 ccgacctggt caccggaaca caaacaccaa caaccacaga gggcgcctca gaatacccag   3231

 agggcccaat acgccgaccc gctgtcacga gcgcccacga gcggcagaac acgacaggca   3291

 cacaaccagc cggagcaaga cggagccgag agccccgggg acatagaccc cagcaagcga   3351

 cacacaagga cgcgcacaga gcgcacacac taaca                              3386




      <210> 661
      <211> 1932
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (337)..(1251)

      <400> 661
 ggcacgaggg gctgggggaa atgacccggg agggtccgat gcggcttaca taaaattggc     60

 agccttagaa ctagtgggaa ggcgggtgcg cgaagtcgag gggcggagag agggggccgg    120

 aggagctgct ttctgaatcc aagttcgtgg gctctctcag aagtcctcag gacggagcag    180

 aggtggccgg cgggcccggc tgactgcgcc tctgctttct ttccataacc ttttctttcg    240

 gactcgaatc acggctgctg cgaagggtct agttccggac actagggtgc ccgaacgcgc    300

 tgatgccccg agtgctcgca gggcttcccg ctaacc  atg ctg ccg ccg ccg cgg     354
                                          Met Leu Pro Pro Pro Arg
                                            1               5

 ccc gca gct gcc ttg gcg ctg cct gtg ctc ctg cta ctg ctg gtg gtg      402
 Pro Ala Ala Ala Leu Ala Leu Pro Val Leu Leu Leu Leu Leu Val Val
              10                  15                  20

 ctg acg ccg ccc ccg acc ggc gca agg cca tcc cca ggc cca gat tac      450
 Leu Thr Pro Pro Pro Thr Gly Ala Arg Pro Ser Pro Gly Pro Asp Tyr
          25                  30                  35

 ctg cgg cgc ggc tgg atg cgg ctg cta gcg gag ggc gag ggc tgc gct      498
 Leu Arg Arg Gly Trp Met Arg Leu Leu Ala Glu Gly Glu Gly Cys Ala
      40                  45                  50

 ccc tgc cgg cca gaa gag tgc gcc gcg ccg cgg ggc tgc ctg gcg ggc      546
 Pro Cys Arg Pro Glu Glu Cys Ala Ala Pro Arg Gly Cys Leu Ala Gly
  55                  60                  65                  70

 agg gtg cgc gac gcg tgc ggc tgc tgc tgg gaa tgc gcc aac ctc gag      594
 Arg Val Arg Asp Ala Cys Gly Cys Cys Trp Glu Cys Ala Asn Leu Glu
                  75                  80                  85

 ggc cag ctc tgc gac ctg gac ccc agt gct cac ttc tac ggg cac tgc      642
 Gly Gln Leu Cys Asp Leu Asp Pro Ser Ala His Phe Tyr Gly His Cys
              90                  95                 100

 ggc gag cag ctt gag tgc cgg ctg gac aca ggc ggc gac ctg agc cgc      690
 Gly Glu Gln Leu Glu Cys Arg Leu Asp Thr Gly Gly Asp Leu Ser Arg
         105                 110                 115

 gga gag gtg ccg gaa cct ctg tgt gcc tgt cgt tcg cag agt ccg ctc      738
 Gly Glu Val Pro Glu Pro Leu Cys Ala Cys Arg Ser Gln Ser Pro Leu
     120                 125                 130

 tgc ggg tcc gac ggt cac acc tac tcc cag atc tgc cgc ctg cag gag      786
 Cys Gly Ser Asp Gly His Thr Tyr Ser Gln Ile Cys Arg Leu Gln Glu
 135                 140                 145                 150

 gcg gcc cgc gct cgg ccc gat gcc aac ctc act gtg gca cac ccg ggg      834
 Ala Ala Arg Ala Arg Pro Asp Ala Asn Leu Thr Val Ala His Pro Gly
                 155                 160                 165

 ccc tgc gaa tcg ggg ccc cag atc gtg tca cat cca tat gac act tgg      882
 Pro Cys Glu Ser Gly Pro Gln Ile Val Ser His Pro Tyr Asp Thr Trp
             170                 175                 180

 aat gtg aca ggg cag gat gtg atc ttt ggc tgt gaa gtg ttt gcc tac      930
 Asn Val Thr Gly Gln Asp Val Ile Phe Gly Cys Glu Val Phe Ala Tyr
         185                 190                 195

 ccc atg gcc tcc atc gag tgg agg aag gat ggc ttg gac atc cag ctg      978
 Pro Met Ala Ser Ile Glu Trp Arg Lys Asp Gly Leu Asp Ile Gln Leu
     200                 205                 210

 cca ggg gat gac ccc cac atc tct gtg cag ttt agg ggt gga ccc cag     1026
 Pro Gly Asp Asp Pro His Ile Ser Val Gln Phe Arg Gly Gly Pro Gln
 215                 220                 225                 230

 agg ttt gag gtg act ggc tgg ctg cag atc cag gct gtg cgt ccc agt     1074
 Arg Phe Glu Val Thr Gly Trp Leu Gln Ile Gln Ala Val Arg Pro Ser
                 235                 240                 245

 gat gag ggc act tac cgc tgc ctt ggc cgc aat gcc ctg ggt caa gtg     1122
 Asp Glu Gly Thr Tyr Arg Cys Leu Gly Arg Asn Ala Leu Gly Gln Val
             250                 255                 260

 gag gcc cct gct agc ttg aca gtg ctc aca cct gac cag ctg aac tct     1170
 Glu Ala Pro Ala Ser Leu Thr Val Leu Thr Pro Asp Gln Leu Asn Ser
         265                 270                 275

 aca ggc atc ccc cag ctg cga tca cta aac ctg gtt cct gag gag gag     1218
 Thr Gly Ile Pro Gln Leu Arg Ser Leu Asn Leu Val Pro Glu Glu Glu
     280                 285                 290

 gct gag agt gaa gag aat gac gat tac tac tag gtccagag ctctggccca     1269
 Ala Glu Ser Glu Glu Asn Asp Asp Tyr Tyr 
 295                 300

 tgggggtggg tgagcggcta tagtgttcat ccctgctctt gaaaagacct ggaaagggga   1329

 gcagggtccc ttcatcgact gctttcatgc tgtcagtagg gatgatcatg ggaggcctat   1389

 ttgactccaa ggtagcagtg tggtaggata gagacaaaag ctggaggagg gtagggagag   1449

 aagctgagac caggaccggt ggggtacaaa ggggcccatg caggagatgc cctggccagt   1509

 aggacctcca acaggttgtt tcccaggctg gggtgggggc ctgagcagac acagaggtgc   1569

 aggcaccagg attctccact tcttccagcc ctgctgggcc acagttctaa ctgcccttcc   1629

 tcccaggccc tggttcttgc tatttcctgg tccccaacgt ttatctagct tgtttgccct   1689

 ttccccaaac tcatcttcca gaacttttcc ctctctccta agccccagtt gcacctacta   1749

 actgcagtcc cttttgctgt ctgccgtctt ttgtacaaga gagagaacag cggagcatga   1809

 cttagttcag tgcagagaga taggtgaggc cagctcgaga tcttatacca ctctgtattg   1869

 gacaaaggct agcacagggc taggcaccaa taaagatttc taatgatgca cagaaaaaaa   1929

 aaa                                                                 1932




      <210> 662
      <211> 3044
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(2463)

      <400> 662
 gttacttgtt attggtaaat agccact    atg gag gct aag gac cag aag aaa      51
                                  Met Glu Ala Lys Asp Gln Lys Lys
                                    1               5

 cac aga aag aaa aac agt gga ccc aaa gct gca aag aaa aag aag cgg       99
 His Arg Lys Lys Asn Ser Gly Pro Lys Ala Ala Lys Lys Lys Lys Arg
      10                  15                  20

 ctt ctg cag gat ctc cag cta gga gac gaa gaa gat gcc cgg aag aga      147
 Leu Leu Gln Asp Leu Gln Leu Gly Asp Glu Glu Asp Ala Arg Lys Arg
  25                  30                  35                  40

 aat ccc aaa gct ttt gca gtt cag tct gct gtg cgg atg gct cga tcc      195
 Asn Pro Lys Ala Phe Ala Val Gln Ser Ala Val Arg Met Ala Arg Ser
                  45                  50                  55

 ttt cac agg act cag gat ttg aag aca aaa aag cat cat att cca gtg      243
 Phe His Arg Thr Gln Asp Leu Lys Thr Lys Lys His His Ile Pro Val
              60                  65                  70

 gtt gat cga act cca cta gag ccc cca cca ata gtg gta gtg gtg atg      291
 Val Asp Arg Thr Pro Leu Glu Pro Pro Pro Ile Val Val Val Val Met
          75                  80                  85

 gga cct cca aaa gtt gga aag agc act ttg ata caa tgc ctc att cgg      339
 Gly Pro Pro Lys Val Gly Lys Ser Thr Leu Ile Gln Cys Leu Ile Arg
      90                  95                 100

 aac ttt acc cgg cag aag ttg acc gag atc aga ggc cct gtg acg att      387
 Asn Phe Thr Arg Gln Lys Leu Thr Glu Ile Arg Gly Pro Val Thr Ile
 105                 110                 115                 120

 gtg tca ggt aaa aag cgc aga ctc acc att att gaa tgt ggg tgt gac      435
 Val Ser Gly Lys Lys Arg Arg Leu Thr Ile Ile Glu Cys Gly Cys Asp
                 125                 130                 135

 att aac atg atg att gat ctg gct aaa gta gca gat ctg gta ctg atg      483
 Ile Asn Met Met Ile Asp Leu Ala Lys Val Ala Asp Leu Val Leu Met
             140                 145                 150

 ctt ata gat gcc agc ttt ggg ttt gaa atg gaa acg ttt gag ttt cta      531
 Leu Ile Asp Ala Ser Phe Gly Phe Glu Met Glu Thr Phe Glu Phe Leu
         155                 160                 165

 aac atc tgt caa gta cat ggc ttt cct aaa att atg gga gtt ctc acc      579
 Asn Ile Cys Gln Val His Gly Phe Pro Lys Ile Met Gly Val Leu Thr
     170                 175                 180

 cac ctc gac tcc ttc aag cat aat aag caa ctg aag aag aca aag aag      627
 His Leu Asp Ser Phe Lys His Asn Lys Gln Leu Lys Lys Thr Lys Lys
 185                 190                 195                 200

 cga tta aaa cac agg ttc tgg acg gaa gtt tac ccg ggt gcc aag ctg      675
 Arg Leu Lys His Arg Phe Trp Thr Glu Val Tyr Pro Gly Ala Lys Leu
                 205                 210                 215

 ttc tac ctt tct gga atg gtg cat gga gaa tat caa aac caa gaa atc      723
 Phe Tyr Leu Ser Gly Met Val His Gly Glu Tyr Gln Asn Gln Glu Ile
             220                 225                 230

 cac aat ctg ggc cgt ttt att aca gtt atg aag ttt agg cct ctc aca      771
 His Asn Leu Gly Arg Phe Ile Thr Val Met Lys Phe Arg Pro Leu Thr
         235                 240                 245

 tgg caa act tct cac cct tat atc ctg gca gac agg atg gaa gat ttg      819
 Trp Gln Thr Ser His Pro Tyr Ile Leu Ala Asp Arg Met Glu Asp Leu
     250                 255                 260

 aca aac cca gag gat atc cga aca aac atc aaa tgt gac cgg aag gtg      867
 Thr Asn Pro Glu Asp Ile Arg Thr Asn Ile Lys Cys Asp Arg Lys Val
 265                 270                 275                 280

 tca ctt tat ggt tat tta aga gga gca cac ttg aaa aat aaa agc caa      915
 Ser Leu Tyr Gly Tyr Leu Arg Gly Ala His Leu Lys Asn Lys Ser Gln
                 285                 290                 295

 att cac atg cca ggg gta gga gat ttt gcc gtg agt gac atc agt ttc      963
 Ile His Met Pro Gly Val Gly Asp Phe Ala Val Ser Asp Ile Ser Phe
             300                 305                 310

 ctc cca gac cct tgc gct ctt cct gaa caa caa aag aag cgc tgt tta     1011
 Leu Pro Asp Pro Cys Ala Leu Pro Glu Gln Gln Lys Lys Arg Cys Leu
         315                 320                 325

 aat gag aag gag aag ctg gtt tat gcg cct ctt tct gga gtt ggg ggt     1059
 Asn Glu Lys Glu Lys Leu Val Tyr Ala Pro Leu Ser Gly Val Gly Gly
     330                 335                 340

 gtg ctg tat gac aaa gac gct gtc tat gtt gac ctt ggt ggc agc cac     1107
 Val Leu Tyr Asp Lys Asp Ala Val Tyr Val Asp Leu Gly Gly Ser His
 345                 350                 355                 360

 gtt ttt cag gat gaa gtg ggg ccc acc cat gag ctg gtc cag agt ctc     1155
 Val Phe Gln Asp Glu Val Gly Pro Thr His Glu Leu Val Gln Ser Leu
                 365                 370                 375

 atc tct acc cac tcc acc att gat gcc aag atg gct tca agt cga gtg     1203
 Ile Ser Thr His Ser Thr Ile Asp Ala Lys Met Ala Ser Ser Arg Val
             380                 385                 390

 acg ctg ttt tct gat tcc aaa cca ctt ggg tca gag gat ata gat aat     1251
 Thr Leu Phe Ser Asp Ser Lys Pro Leu Gly Ser Glu Asp Ile Asp Asn
         395                 400                 405

 caa ggg cta atg atg cca aag gag gaa aaa caa atg gac ttg aac act     1299
 Gln Gly Leu Met Met Pro Lys Glu Glu Lys Gln Met Asp Leu Asn Thr
     410                 415                 420

 ggt cga atg cgt cgg aaa gcc att ttc gga gat gaa gat gaa tct gga     1347
 Gly Arg Met Arg Arg Lys Ala Ile Phe Gly Asp Glu Asp Glu Ser Gly
 425                 430                 435                 440

 gat agt gat gat gaa gaa gat gat gaa atg tct gaa gat gac ggg ttg     1395
 Asp Ser Asp Asp Glu Glu Asp Asp Glu Met Ser Glu Asp Asp Gly Leu
                 445                 450                 455

 gaa aac ggc tct agt gat gag gaa gca gaa gag gag gaa aat gct gag     1443
 Glu Asn Gly Ser Ser Asp Glu Glu Ala Glu Glu Glu Glu Asn Ala Glu
             460                 465                 470

 atg act gat cag tat atg gct gtt aag ggc atc aaa cga cgg aaa ctt     1491
 Met Thr Asp Gln Tyr Met Ala Val Lys Gly Ile Lys Arg Arg Lys Leu
         475                 480                 485

 gag ttg gaa gaa gac agt gaa atg gat ttg cca gca ttt gct gac agt     1539
 Glu Leu Glu Glu Asp Ser Glu Met Asp Leu Pro Ala Phe Ala Asp Ser
     490                 495                 500

 gac gat gac ctt gag agg agc tca gcg gaa gaa ggg gaa gcg gag gaa     1587
 Asp Asp Asp Leu Glu Arg Ser Ser Ala Glu Glu Gly Glu Ala Glu Glu
 505                 510                 515                 520

 gct gat gaa agc agt gaa gaa gag gac tgc act gca gga gag aag ggc     1635
 Ala Asp Glu Ser Ser Glu Glu Glu Asp Cys Thr Ala Gly Glu Lys Gly
                 525                 530                 535

 att tca gga tca aag gct gct gga gaa ggt agt aaa gca ggg ctg tca     1683
 Ile Ser Gly Ser Lys Ala Ala Gly Glu Gly Ser Lys Ala Gly Leu Ser
             540                 545                 550

 cca gct aat tgc cag agt gac cgt gtg aat ctg gag aag tct ttg ctg     1731
 Pro Ala Asn Cys Gln Ser Asp Arg Val Asn Leu Glu Lys Ser Leu Leu
         555                 560                 565

 atg aag aaa gca gct ctc ccc act ttc gat tct ggg cat tgc aca gct     1779
 Met Lys Lys Ala Ala Leu Pro Thr Phe Asp Ser Gly His Cys Thr Ala
     570                 575                 580

 gaa gag gtg ttt gca tct gaa gat gaa tct gaa gaa agc tcc tca ctc     1827
 Glu Glu Val Phe Ala Ser Glu Asp Glu Ser Glu Glu Ser Ser Ser Leu
 585                 590                 595                 600

 agt gca gag gaa gaa gac tca gaa aat gaa gag gct att aga aaa aag     1875
 Ser Ala Glu Glu Glu Asp Ser Glu Asn Glu Glu Ala Ile Arg Lys Lys
                 605                 610                 615

 ctt tca aag cct tct caa gtg agc agt ggt cag aaa ctg ggg cca cag     1923
 Leu Ser Lys Pro Ser Gln Val Ser Ser Gly Gln Lys Leu Gly Pro Gln
             620                 625                 630

 aac ttc att gat gag acc agt gat ata gaa aat tta ctc aaa gag gaa     1971
 Asn Phe Ile Asp Glu Thr Ser Asp Ile Glu Asn Leu Leu Lys Glu Glu
         635                 640                 645

 gaa gat tac aag gaa gaa aat aat gat tcc aaa gaa acg tca ggt gcc     2019
 Glu Asp Tyr Lys Glu Glu Asn Asn Asp Ser Lys Glu Thr Ser Gly Ala
     650                 655                 660

 ctc aag tgg aag gaa gac ctt tcc aga aag gca gct gag gcc ttt ctg     2067
 Leu Lys Trp Lys Glu Asp Leu Ser Arg Lys Ala Ala Glu Ala Phe Leu
 665                 670                 675                 680

 agg cag cag caa gca gct cca aac ctc cga aag ctt att tat ggg aca     2115
 Arg Gln Gln Gln Ala Ala Pro Asn Leu Arg Lys Leu Ile Tyr Gly Thr
                 685                 690                 695

 gtg aca gaa gat aat gaa gaa gaa gat gat gat act cta gaa gag ctt     2163
 Val Thr Glu Asp Asn Glu Glu Glu Asp Asp Asp Thr Leu Glu Glu Leu
             700                 705                 710

 gga ggg ttg ttt cgt gtc aac cag cct gac aga gag tgt aag cac aag     2211
 Gly Gly Leu Phe Arg Val Asn Gln Pro Asp Arg Glu Cys Lys His Lys
         715                 720                 725

 gct gac tct ttg gac tgc tcc aga ttt ctt gtg gag gcc ccc cat gac     2259
 Ala Asp Ser Leu Asp Cys Ser Arg Phe Leu Val Glu Ala Pro His Asp
     730                 735                 740

 tgg gat tta gag gag gtt atg aac agt atc aga gat tgc ttc gtg act     2307
 Trp Asp Leu Glu Glu Val Met Asn Ser Ile Arg Asp Cys Phe Val Thr
 745                 750                 755                 760

 gga aag tgg gaa gat gat aaa gat gca gcc aag gtc tta gca gaa gat     2355
 Gly Lys Trp Glu Asp Asp Lys Asp Ala Ala Lys Val Leu Ala Glu Asp
                 765                 770                 775

 gag gag ctc tac ggt gac ttt gaa gac ttg gaa aca ggg gac gtg cac     2403
 Glu Glu Leu Tyr Gly Asp Phe Glu Asp Leu Glu Thr Gly Asp Val His
             780                 785                 790

 aag gga aaa tcg ggc ccc gat act cag aat gaa gat ata gag aaa caa     2451
 Lys Gly Lys Ser Gly Pro Asp Thr Gln Asn Glu Asp Ile Glu Lys Gln
         795                 800                 805

 gga aga aat tga ccc cgacgaagaa gaaagtgcca agaaaaagca tttggataag     2506
 Gly Arg Asn 
     810

 aagagaaaat tgaaggagat gtttgatgcg gaatatgatg aaggagaaag cacatatttt   2566

 gatgatctta aaggagaaat gcagaaacaa gcacagctga atcacgcaga atttgaagat   2626

 caagatgatg aagccagagt tcagtatgag ggttttcgac ctgggatgta cgtccgcgtt   2686

 gagattgaaa atgttccctg tgaatttgtg cagaactttg acccccatta ccccattatc   2746

 ctgggtggct tgggcaacag cgagggaaat gttggacacg tgcagatgcg tctgaagaaa   2806

 catcgctggt ataagaaaat cctcaagtcc caagatccaa tcatattttc tgtagggtgg   2866

 aggaggtttc agaccatcct gctctattat attgaagacc acaatggaag acaaaggctt   2926

 ctaaagtata ccccacagca catgcattgt ggagcagcct tttggggtaa aatatgatta   2986

 caataacttg cctattgccg agattaaact ttacaggctg cgtctcagaa caacgaca     3044




      <210> 663
      <211> 1851
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (571)..(1317)

      <400> 663
 ggtcgaccca cgcgtccgcc cacgcgtccg ctggactgtg ggttgggggc agcctcagcc     60

 tctccaacct ggcacccact gcccgtggcc cttaggcacc tgcttggggt cctggagccc    120

 cttaaggcca ccagcaaatc ctaggagacc gagtcttggc acgtgaacag agccagattt    180

 cacactgagc agctgcagtc ggagaaatca gagaaagcgt cacccagccc cagattccga    240

 ggggcctgcc agggactctc tcctcctgct ccttggaaag gaagaccccg aaagaccccc    300

 aagccaccgg ctcagacctg cttctgggct gccatgggac ttgcggccac cgccccccgg    360

 ctgtcctcca cgctgccggg cagataaggg cagctgctgc ccttggggca cctgctcact    420

 cccgcagccc agccactcct ccagggccag cccttccctg actcagtgac cacctctgct    480

 gccccgaggc catgtaggcc gtgcttaggc ctctgtggac acactgctgg ggacggcgcc    540

 tgagctctca gggggacgag gaacaccacg     atg ccc cgg ggc ttc acc tgg     591
                                      Met Pro Arg Gly Phe Thr Trp
                                        1               5

 ctg cgc tat ctt ggg atc ttc ctt ggc gtg gcc ttg ggg aat gag cct      639
 Leu Arg Tyr Leu Gly Ile Phe Leu Gly Val Ala Leu Gly Asn Glu Pro
          10                  15                  20

 ttg gag atg tgg ccc ttg acg cag aat gag gag tgc act gtc acg ggt      687
 Leu Glu Met Trp Pro Leu Thr Gln Asn Glu Glu Cys Thr Val Thr Gly
      25                  30                  35

 ttt ctg cgg gac aag ctg cag tac agg agc cga ctt cag tac atg aaa      735
 Phe Leu Arg Asp Lys Leu Gln Tyr Arg Ser Arg Leu Gln Tyr Met Lys
  40                  45                  50                  55

 cac tac ttc ccc atc aac tac aag atc agt gtg cct tac gag ggg gtg      783
 His Tyr Phe Pro Ile Asn Tyr Lys Ile Ser Val Pro Tyr Glu Gly Val
                  60                  65                  70

 ttc aga atc gcc aac gtc acc agg ctg cag agg gcc cag gtg agc gag      831
 Phe Arg Ile Ala Asn Val Thr Arg Leu Gln Arg Ala Gln Val Ser Glu
              75                  80                  85

 cgg gag ctg cgg tat ctg tgg gtc ttg gtg agc ctc agt gcc act gag      879
 Arg Glu Leu Arg Tyr Leu Trp Val Leu Val Ser Leu Ser Ala Thr Glu
          90                  95                 100

 tcg gtg cag gac gtg ctg ctc gag ggc cac cca tcc tgg aag tac ctg      927
 Ser Val Gln Asp Val Leu Leu Glu Gly His Pro Ser Trp Lys Tyr Leu
     105                 110                 115

 cag gag gtg cag acg ctg ctg ctg aat gtc cag cag ggc ctc acg gat      975
 Gln Glu Val Gln Thr Leu Leu Leu Asn Val Gln Gln Gly Leu Thr Asp
 120                 125                 130                 135

 gtg gag gtc agc ccc aag gtg gaa tcc gtg ttg tcc ctc ttg aat gcc     1023
 Val Glu Val Ser Pro Lys Val Glu Ser Val Leu Ser Leu Leu Asn Ala
                 140                 145                 150

 cca ggg cca aac ctg aag ctg gtg cgg ccc aaa gcc ctg ctg gac aac     1071
 Pro Gly Pro Asn Leu Lys Leu Val Arg Pro Lys Ala Leu Leu Asp Asn
             155                 160                 165

 tgc ttc cgg gtc atg gag ctg ctg tac tgc tcc tgc tgt aaa caa agc     1119
 Cys Phe Arg Val Met Glu Leu Leu Tyr Cys Ser Cys Cys Lys Gln Ser
         170                 175                 180

 tcc gtc cta aac tgg cag gac tgt gag gtg cca agt cct cag tct tgc     1167
 Ser Val Leu Asn Trp Gln Asp Cys Glu Val Pro Ser Pro Gln Ser Cys
     185                 190                 195

 agc cca gag ccc tca ttg cag tat gcg gcc acc cag ctg tac cct ccg     1215
 Ser Pro Glu Pro Ser Leu Gln Tyr Ala Ala Thr Gln Leu Tyr Pro Pro
 200                 205                 210                 215

 ggc ccc gtg gtc ccc cag ctc ccc gcc tca ctc cac ggg ctc ggt gag     1263
 Gly Pro Val Val Pro Gln Leu Pro Ala Ser Leu His Gly Leu Gly Glu
                 220                 225                 230

 gtc cgg tca ggg cac agg gcg agg gcc tct tgc cct gag cac cct gga     1311
 Val Arg Ser Gly His Arg Ala Arg Ala Ser Cys Pro Glu His Pro Gly
             235                 240                 245

 tgg tga ctgcggatag gggcagccag accagctccc acaggagttc aactgggtct      1367
 Trp 


 gagacttcaa ggggtggtgg tgggagcccc ccttgggaga ggacccctgg gaagggtgtt   1427

 tttcctttga gggggattct gtgccacagc agggctcagc ttcctgcctt ccatagctgt   1487

 catggcctca cctggagccg cgaggggacc ttggggacct gaagggtgga tggggacaca   1547

 gctcctggct tctcctgggt gctgccctca ctgtcccccc gcctaaaggg ggtactgagc   1607

 ctcctgtggc ccgcagcagt gagggcacag ctgtgggttg caggggagac agccagcacg   1667

 gcgtggccat tctatgaccc acccagcctg gcagactggg gagctggggg cagagggcgg   1727

 tgcaaagtgc cacatctgcc atagttgtac tgctttataa aaaccaggtg tgcgtttttt   1787

 tttcgtaagt taaaccaccc ccccacgttc cattcctcct ctctcctcct cgctcccccc   1847

 ctct                                                                1851




      <210> 664
      <211> 3777
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(3251)

      <400> 664
 gaaactggga cattttactt tacagtctat taaaggttat acaaaactta aaagaagcag     60

 caattctatt cgcttgttat tggacttgaa actccctttg acctcggaaa ctgaag        116                                                                 
 atg agg ttg cca tgg gaa ctg ctg gta ctg caa tca ttc att ttg tgc      164
 Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys
   1               5                  10                  15

 ctt gca ggt tca cag act gac ttc tgg tcc ttg ctg ggg gtg ctg cca      212
 Leu Ala Gly Ser Gln Thr Asp Phe Trp Ser Leu Leu Gly Val Leu Pro
              20                  25                  30

 gcc ttg gag gct gat gat tcc aca ctg cat ggc ccg att ttt att caa      260
 Ala Leu Glu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln
          35                  40                  45

 gaa cca agt cct gta atg ttc cct ttg gat tct gag gag aaa aaa gtg      308
 Glu Pro Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val
      50                  55                  60

 aag ctc aat tgt gaa gtt aaa gga aat cca aaa cct cat atc agg tgg      356
 Lys Leu Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp
  65                  70                  75                  80

 aag tta aat gga aca gat gtt gac act ggt atg gat ttc cgc tac agt      404
 Lys Leu Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser
                  85                  90                  95

 gtt gtt gaa ggg agc ttg ttg atc aat aac ccc aat aaa acc caa gat      452
 Val Val Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp
             100                 105                 110

 gct gga acg tac cag tgc aca gcg aca aac tcg ttt gga aca att gtt      500
 Ala Gly Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val
         115                 120                 125

 agc aga gaa gca aag ctt cag ttt gct tat ctt gac aac ttt aaa aca      548
 Ser Arg Glu Ala Lys Leu Gln Phe Ala Tyr Leu Asp Asn Phe Lys Thr
     130                 135                 140

 aga aca aga agc act gtg tct gtc cgt cga ggt caa gga atg gtg cta      596
 Arg Thr Arg Ser Thr Val Ser Val Arg Arg Gly Gln Gly Met Val Leu
 145                 150                 155                 160

 ctg tgt ggc ccg cca ccc cat tct gga gag ctg agt tat gcc tgg atc      644
 Leu Cys Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile
                 165                 170                 175

 ttc aat gaa tac cct tcc tat cag gat aat cgc cgc ttt gtt tct caa      692
 Phe Asn Glu Tyr Pro Ser Tyr Gln Asp Asn Arg Arg Phe Val Ser Gln
             180                 185                 190

 gag act ggg aat ctg tat att gcc aaa gta gaa aaa tca gat gtt ggg      740
 Glu Thr Gly Asn Leu Tyr Ile Ala Lys Val Glu Lys Ser Asp Val Gly
         195                 200                 205

 aat tat acc tgt gtg gtt acc aat acc gtg aca aac cac aag gtc ctg      788
 Asn Tyr Thr Cys Val Val Thr Asn Thr Val Thr Asn His Lys Val Leu
     210                 215                 220

 ggg cca cct aca cca cta ata ttg aga aat gat gga gtg atg ggt gaa      836
 Gly Pro Pro Thr Pro Leu Ile Leu Arg Asn Asp Gly Val Met Gly Glu
 225                 230                 235                 240

 tat gag ccc aaa ata gaa gtg cag ttc cca gaa aca gtt ccg act gca      884
 Tyr Glu Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Val Pro Thr Ala
                 245                 250                 255

 aaa gga gca acg gtg aag ctg gaa tgc ttt gct tta gga aat cca gta      932
 Lys Gly Ala Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val
             260                 265                 270

 cca act att atc tgg cga aga gct gat gga aag cca ata gca agg aaa      980
 Pro Thr Ile Ile Trp Arg Arg Ala Asp Gly Lys Pro Ile Ala Arg Lys
         275                 280                 285

 gcc aga aga cac aag tca aat gga att ctt gag atc cct aat ttt cag     1028
 Ala Arg Arg His Lys Ser Asn Gly Ile Leu Glu Ile Pro Asn Phe Gln
     290                 295                 300

 cag gag gat gct ggt tta tat gaa tgt gta gct gaa aat tcc aga ggg     1076
 Gln Glu Asp Ala Gly Leu Tyr Glu Cys Val Ala Glu Asn Ser Arg Gly
 305                 310                 315                 320

 aaa aat gta gca agg gga cag cta act ttc tat gct caa cct aat tgg     1124
 Lys Asn Val Ala Arg Gly Gln Leu Thr Phe Tyr Ala Gln Pro Asn Trp
                 325                 330                 335

 att caa aaa ata aat gat att cac gtg gcc atg gaa gaa aat gtc ttt     1172
 Ile Gln Lys Ile Asn Asp Ile His Val Ala Met Glu Glu Asn Val Phe
             340                 345                 350

 tgg gaa tgt aaa gca aat gga agg cct aag cct aca tac aag tgg cta     1220
 Trp Glu Cys Lys Ala Asn Gly Arg Pro Lys Pro Thr Tyr Lys Trp Leu
         355                 360                 365

 aaa aat ggc gaa cct ctg cta act cgg gat aga att caa att gag caa     1268
 Lys Asn Gly Glu Pro Leu Leu Thr Arg Asp Arg Ile Gln Ile Glu Gln
     370                 375                 380

 gga aca ctc aac ata aca ata gtg aac ctc tca gat gct ggc atg tat     1316
 Gly Thr Leu Asn Ile Thr Ile Val Asn Leu Ser Asp Ala Gly Met Tyr
 385                 390                 395                 400

 cag tgt ttg gca gag aat aaa cat gga gtt atc ttt tcc aac gca gag     1364
 Gln Cys Leu Ala Glu Asn Lys His Gly Val Ile Phe Ser Asn Ala Glu
                 405                 410                 415

 ctt agt gtt ata gct gta ggt cca gat ttt tca aga aca ctc ttg aaa     1412
 Leu Ser Val Ile Ala Val Gly Pro Asp Phe Ser Arg Thr Leu Leu Lys
             420                 425                 430

 aga gta act ctt gtc aaa gtg gga ggt gaa gtt gtc att gag tgt aag     1460
 Arg Val Thr Leu Val Lys Val Gly Gly Glu Val Val Ile Glu Cys Lys
         435                 440                 445

 cca aaa gcg tct cca aaa cct gtt tac acc tgg aag aaa gga agg gat     1508
 Pro Lys Ala Ser Pro Lys Pro Val Tyr Thr Trp Lys Lys Gly Arg Asp
     450                 455                 460

 ata tta aaa gaa aat gaa aga att acc att tct gaa gat gga aac ctc     1556
 Ile Leu Lys Glu Asn Glu Arg Ile Thr Ile Ser Glu Asp Gly Asn Leu
 465                 470                 475                 480

 aga atc atc aac gtt act aaa tca gac gct ggg agt tat acc tgt ata     1604
 Arg Ile Ile Asn Val Thr Lys Ser Asp Ala Gly Ser Tyr Thr Cys Ile
                 485                 490                 495

 gcc act aac cat ttt gga act gct agc agt act gga aac ttg gta gtg     1652
 Ala Thr Asn His Phe Gly Thr Ala Ser Ser Thr Gly Asn Leu Val Val
             500                 505                 510

 aaa gat cca aca agg gta atg gta ccc cct tcc agt atg gat gtc act     1700
 Lys Asp Pro Thr Arg Val Met Val Pro Pro Ser Ser Met Asp Val Thr
         515                 520                 525

 gtt gga gag agt att gtt tta ccg tgc cag gta acg cat gat cac tcg     1748
 Val Gly Glu Ser Ile Val Leu Pro Cys Gln Val Thr His Asp His Ser
     530                 535                 540

 cta gac atc gtg ttt act tgg tca ttt aat gga cac ctg ata gac ttt     1796
 Leu Asp Ile Val Phe Thr Trp Ser Phe Asn Gly His Leu Ile Asp Phe
 545                 550                 555                 560

 gac aga gat ggg gac cac ttt gaa aga gtt gga ggg cag gat tca gct     1844
 Asp Arg Asp Gly Asp His Phe Glu Arg Val Gly Gly Gln Asp Ser Ala
                 565                 570                 575

 ggt gat ttg atg atc cga aac atc caa ctg aag cat gct ggg aaa tat     1892
 Gly Asp Leu Met Ile Arg Asn Ile Gln Leu Lys His Ala Gly Lys Tyr
             580                 585                 590

 gtc tgc atg gtc caa aca agt gtg gac agg cta tct gct gct gca gac     1940
 Val Cys Met Val Gln Thr Ser Val Asp Arg Leu Ser Ala Ala Ala Asp
         595                 600                 605

 ctg att gta aga ggt cct cca ggt ccc cca gag gct gtg aca ata gac     1988
 Leu Ile Val Arg Gly Pro Pro Gly Pro Pro Glu Ala Val Thr Ile Asp
     610                 615                 620

 gaa atc aca gat acc act gct cag ctc tcc tgg aga ccc ggg cct gac     2036
 Glu Ile Thr Asp Thr Thr Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp
 625                 630                 635                 640

 aat cac agc ccc atc acc atg tat gtc att caa gcc agg act ccg ttc     2084
 Asn His Ser Pro Ile Thr Met Tyr Val Ile Gln Ala Arg Thr Pro Phe
                 645                 650                 655

 tcc gtg ggc tgg caa gca gtc agt aca gtc cca gaa ctc att gat ggg     2132
 Ser Val Gly Trp Gln Ala Val Ser Thr Val Pro Glu Leu Ile Asp Gly
             660                 665                 670

 aag aca ttc aca gcg acc gtg gtg ggt ttg aac cct tgg gtt gaa tat     2180
 Lys Thr Phe Thr Ala Thr Val Val Gly Leu Asn Pro Trp Val Glu Tyr
         675                 680                 685

 gaa ttc cgc aca gtt gca gcc aac gtg att ggg att ggg gag ccc agc     2228
 Glu Phe Arg Thr Val Ala Ala Asn Val Ile Gly Ile Gly Glu Pro Ser
     690                 695                 700

 cgc ccc tca gag aaa cgg aga aca gaa gaa gct ctc ccc gaa gtc aca     2276
 Arg Pro Ser Glu Lys Arg Arg Thr Glu Glu Ala Leu Pro Glu Val Thr
 705                 710                 715                 720

 cca gcg aat gtc agt ggt ggc gga ggc agc aaa tct gaa ctg gtt ata     2324
 Pro Ala Asn Val Ser Gly Gly Gly Gly Ser Lys Ser Glu Leu Val Ile
                 725                 730                 735

 acc tgg gag acg gtc cct gag gaa tta cag aat ggt cga ggc ttt ggt     2372
 Thr Trp Glu Thr Val Pro Glu Glu Leu Gln Asn Gly Arg Gly Phe Gly
             740                 745                 750

 tat gtg gtg gcc ttc cgg ccc tac ggt aaa atg atc tgg atg ctg aca     2420
 Tyr Val Val Ala Phe Arg Pro Tyr Gly Lys Met Ile Trp Met Leu Thr
         755                 760                 765

 gtg ctg gcc tca gct gac gcc tct aga tac gtg ttc agg aat gag agc     2468
 Val Leu Ala Ser Ala Asp Ala Ser Arg Tyr Val Phe Arg Asn Glu Ser
     770                 775                 780

 gtg cac ccc ttc tct ccc ttt gag gtt aaa gta ggt gtc ttc aac aac     2516
 Val His Pro Phe Ser Pro Phe Glu Val Lys Val Gly Val Phe Asn Asn
 785                 790                 795                 800

 aaa gga gaa ggc cct ttc agt ccc acc acg gtg gtg tat tct gca gaa     2564
 Lys Gly Glu Gly Pro Phe Ser Pro Thr Thr Val Val Tyr Ser Ala Glu
                 805                 810                 815

 gaa gaa ccc acc aaa cca cca gcc agt atc ttt gcc aga agt ctt tct     2612
 Glu Glu Pro Thr Lys Pro Pro Ala Ser Ile Phe Ala Arg Ser Leu Ser
             820                 825                 830

 gcc aca gat att gaa gtt ttc tgg gcc tcc cca ctg gag aag aat aga     2660
 Ala Thr Asp Ile Glu Val Phe Trp Ala Ser Pro Leu Glu Lys Asn Arg
         835                 840                 845

 gga cga ata caa ggt tat gag gtt aaa tat tgg aga cat gaa gac aaa     2708
 Gly Arg Ile Gln Gly Tyr Glu Val Lys Tyr Trp Arg His Glu Asp Lys
     850                 855                 860

 gaa gaa aat gct aga aaa ata cga aca gtt gga aat cag aca tca aca     2756
 Glu Glu Asn Ala Arg Lys Ile Arg Thr Val Gly Asn Gln Thr Ser Thr
 865                 870                 875                 880

 aaa atc acg aac tta aaa ggc agt gtg ctg tat cac tta gct gtc aag     2804
 Lys Ile Thr Asn Leu Lys Gly Ser Val Leu Tyr His Leu Ala Val Lys
                 885                 890                 895

 gca tat aat tct gct ggg aca ggc ccc tct agt gca aca gtc aat gtg     2852
 Ala Tyr Asn Ser Ala Gly Thr Gly Pro Ser Ser Ala Thr Val Asn Val
             900                 905                 910

 aca acc cga aag cca cca cca agt caa ccc ccc gga aac atc ata tgg     2900
 Thr Thr Arg Lys Pro Pro Pro Ser Gln Pro Pro Gly Asn Ile Ile Trp
         915                 920                 925

 aat tca tca gac tcc aaa att atc ctg aat tgg gat caa gtg aag gcc     2948
 Asn Ser Ser Asp Ser Lys Ile Ile Leu Asn Trp Asp Gln Val Lys Ala
     930                 935                 940

 ctg gat aat gag tcg gaa gta aaa gga tac aaa gtc ttg tac aga tgg     2996
 Leu Asp Asn Glu Ser Glu Val Lys Gly Tyr Lys Val Leu Tyr Arg Trp
 945                 950                 955                 960

 aac aga caa agc agc aca tct gtc att gaa aca aat aaa aca tcg gtg     3044
 Asn Arg Gln Ser Ser Thr Ser Val Ile Glu Thr Asn Lys Thr Ser Val
                 965                 970                 975

 gag ctt tct ttg cct ttc gat gaa gat tat ata ata gaa att aag cca     3092
 Glu Leu Ser Leu Pro Phe Asp Glu Asp Tyr Ile Ile Glu Ile Lys Pro
             980                 985                 990

 ttc agc gac gga gga gat ggc agc agc agt gaa caa att cga att cca     3140
 Phe Ser Asp Gly Gly Asp Gly Ser Ser Ser Glu Gln Ile Arg Ile Pro
         995                1000                1005

 aag ata tca aat gcc tac gcg aga gga tct ggg gct tcc act tcg aat     3188
 Lys Ile Ser Asn Ala Tyr Ala Arg Gly Ser Gly Ala Ser Thr Ser Asn
    1010                1015                1020

 gca tgt acg ctg tca gcc atc agt aca ata atg att tcc ctc aca gct     3236
 Ala Cys Thr Leu Ser Ala Ile Ser Thr Ile Met Ile Ser Leu Thr Ala
1025                1030                1035                1040

 agg tcc agt tta tga caaaagttat ctgaaggact tgctgtttat aatataagca     3291
 Arg Ser Ser Leu 


 acatttagct agttgttttg aagacaccca gtactaagta atattgttgt tcaagtacat   3351

 cttattactg gaataaaaat gttttttgct tctttaggaa tggcattata caagtacttc   3411

 ctcaaagcaa atctagcttt gtctgaagtt tctttggaaa ctctgcaatg ccactgaagg   3471

 acatctggta atatgatgtt caacaaaagc cagtttacat tattgtccct ttaatattgc   3531

 atatctttta ctcatatatt taagaggtta aatcacgaat ctattcacaa cgttcaacct   3591

 atcacatgta cgcatattta acatctctta ccatcggact ggtacaaacg cgtatgggcc   3651

 caccaaccaa tcatgaccat tactaattcg gaaaaataca ttccttcaag cgcacagagt   3711

 ctggacacat catattggga taaataaaat gacacctact acgctaacgg tatacaacgg   3771

 cattca                                                              3777




      <210> 665
      <211> 1269
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (288)..(956)

      <400> 665
 gcaagatgga ggtcgcgcag aggccgccgc ctgggccgag gcagccgctg ctagcagcgc     60

 cgagccgcgg cgcctaggcc gtgccagtcc cggatccgct gcctccggcc gtgcccagca    120

 gctcccagac gcccccagct ctgccccagg ccccgccctc gcgggttcct tgactcaggg    180

 ccgcttctcg cgtgcgtccc cagctcccgc ccggttattc ttgtgctccg tcccgggccg    240

 gcggcccccg ccagtcgccg ccgccgccgg ccccgcctcc gggcacc  atg ctg cct     296
                                                      Met Leu Pro
                                                        1

 tcg cag gag gcc tcc aag ctc tac cac gag cac tac atg cgg aac tcg      344
 Ser Gln Glu Ala Ser Lys Leu Tyr His Glu His Tyr Met Arg Asn Ser
       5                  10                  15

 cgg gcc atc ggc gtg ctg tgg gcc atc ttc acc atc tgc ttt gcc atc      392
 Arg Ala Ile Gly Val Leu Trp Ala Ile Phe Thr Ile Cys Phe Ala Ile
  20                  25                  30                  35

 gtc aac gtg gtg tgc ttc atc cag ccc tac tgg ata ggc gac ggc gtg      440
 Val Asn Val Val Cys Phe Ile Gln Pro Tyr Trp Ile Gly Asp Gly Val
                  40                  45                  50

 gac acc ccg caa gcc ggc tat ttc ggg ctc ttc cac tac tgc atc ggc      488
 Asp Thr Pro Gln Ala Gly Tyr Phe Gly Leu Phe His Tyr Cys Ile Gly
              55                  60                  65

 aac ggc ttc tcc cgg gag ctg acc tgc agg ggc agc ttc acg gac ttc      536
 Asn Gly Phe Ser Arg Glu Leu Thr Cys Arg Gly Ser Phe Thr Asp Phe
          70                  75                  80

 tcc acg ctg ccc tcg ggc gcc ttc aaa gcc gcc tcc ttc ttt atc ggc      584
 Ser Thr Leu Pro Ser Gly Ala Phe Lys Ala Ala Ser Phe Phe Ile Gly
      85                  90                  95

 ctc tcc atg atg ctc atc att gcc tgc atc att tgc ttt acc ctc ttc      632
 Leu Ser Met Met Leu Ile Ile Ala Cys Ile Ile Cys Phe Thr Leu Phe
 100                 105                 110                 115

 ttc ttc tgc aac acg gcc act gtg tac aag ata tgt gcc tgg atg cag      680
 Phe Phe Cys Asn Thr Ala Thr Val Tyr Lys Ile Cys Ala Trp Met Gln
                 120                 125                 130

 ctc acc tcc gct gcc tgc ctt gtg ctt ggc tgt atg att ttc cct gat      728
 Leu Thr Ser Ala Ala Cys Leu Val Leu Gly Cys Met Ile Phe Pro Asp
             135                 140                 145

 ggc tgg gac tca gat gaa gta aaa cgg atg tgt gga gaa aag aca gac      776
 Gly Trp Asp Ser Asp Glu Val Lys Arg Met Cys Gly Glu Lys Thr Asp
         150                 155                 160

 aag tac act ctt ggg gct tgc tca gtc cgc tgg gca tac atc ctg gct      824
 Lys Tyr Thr Leu Gly Ala Cys Ser Val Arg Trp Ala Tyr Ile Leu Ala
     165                 170                 175

 att att gga att ttg gat gcc ctg atc ctc tca ttt cta gca ttt gtg      872
 Ile Ile Gly Ile Leu Asp Ala Leu Ile Leu Ser Phe Leu Ala Phe Val
 180                 185                 190                 195

 ctt ggt aat cga caa gac agc ttg atg gca gag gaa ctg aag gca gaa      920
 Leu Gly Asn Arg Gln Asp Ser Leu Met Ala Glu Glu Leu Lys Ala Glu
                 200                 205                 210

 aac aaa gtt ctg cta agc caa tat tct cta gaa tga gcac aaaacaaatc      970
 Asn Lys Val Leu Leu Ser Gln Tyr Ser Leu Glu 
             215                 220

 gaataacagc taaacaaatc gaataacagc taaacgaatc gaataacagc ttttgtacat   1030

 caacatcaag aaggaatacg cctgagagag atcagagtat atagatgaat atgaacaaga   1090

 atggaacatt cacttgtcaa cgcactttct aaatctagat cagcagagat gggagtgatt   1150

 ttctggaaag agatgtgatc atggattaaa caccagctca ttggaaactc attggatgag   1210

 atcagaaaac gttcatgaaa aatcatattc aggaaataag gaagaggaat ataaagaat    1269




      <210> 666
      <211> 1529
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(1281)

      <400> 666
 gactccagac agacggcttt ggaatccacc agctacatcc agctccctga ggcagagttg     60

 aga  atg gag aga atg tta cct ctc ctg gct ctg ggg ctc ttg gcg gct     108
      Met Glu Arg Met Leu Pro Leu Leu Ala Leu Gly Leu Leu Ala Ala
        1               5                  10                  15

 ggg ttc tgc cct gct gtc ctc tgc cac cct aac agc cca ctt gac gag      156
 Gly Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu
                  20                  25                  30

 gag aat ctg acc cag gag aac caa gac cga ggg aca cac gtg gac ctc      204
 Glu Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu
              35                  40                  45

 gga tta gcc tcc gcc aac gtg gac ttc gct ttc agc ctg tac aag cag      252
 Gly Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln
          50                  55                  60

 tta gtc ctg aag gcc cct gat aag aat gtc atc ttc tcc cca ctg agc      300
 Leu Val Leu Lys Ala Pro Asp Lys Asn Val Ile Phe Ser Pro Leu Ser
      65                  70                  75

 atc tcc acc gcc ttg gcc ttc ctg tct ctg ggg gcc cat aat acc acc      348
 Ile Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr
  80                  85                  90                  95

 ctg aca gag att ctc aaa ggc ctc aag ttc aac ctc acg gag act tct      396
 Leu Thr Glu Ile Leu Lys Gly Leu Lys Phe Asn Leu Thr Glu Thr Ser
                 100                 105                 110

 gag gca gaa att cac cag agc ttc cag cac ctc ctg cgc acc ctc aat      444
 Glu Ala Glu Ile His Gln Ser Phe Gln His Leu Leu Arg Thr Leu Asn
             115                 120                 125

 cag tcc agc gat gag ctg cag ctg agt atg gga aat gcc atg ttt gtc      492
 Gln Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn Ala Met Phe Val
         130                 135                 140

 aaa gag caa ctc agt ctg ctg gac agg ttc acg gag gat gcc aag agg      540
 Lys Glu Gln Leu Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala Lys Arg
     145                 150                 155

 ctg tat ggc tcc gag gcc ttt gcc act gac ttt cag gac tca gct gca      588
 Leu Tyr Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala
 160                 165                 170                 175

 gct aag aag ctc atc aac gac tac gtg aag aat gga act agg ggg aaa      636
 Ala Lys Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys
                 180                 185                 190

 atc aca gat ctg atc aag gac ctt gac tcg cag aca atg atg gtc ctg      684
 Ile Thr Asp Leu Ile Lys Asp Leu Asp Ser Gln Thr Met Met Val Leu
             195                 200                 205

 gtg aat tac atc ttc ttt aaa gcc aaa tgg gag atg ccc ttt gac ccc      732
 Val Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro
         210                 215                 220

 caa gat act cat cag tca agg ttc tac ttg agc aag aaa aag tgg gta      780
 Gln Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val
     225                 230                 235

 atg gtg ccc atg atg agt ttg cat cac ctg act ata cct tac ttc cgg      828
 Met Val Pro Met Met Ser Leu His His Leu Thr Ile Pro Tyr Phe Arg
 240                 245                 250                 255

 gac gag gag ctg tcc tgc acc gtg gtg gag ctg aag tac aca ggc aat      876
 Asp Glu Glu Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn
                 260                 265                 270

 gcc agc gca ctc ttc atc ctc cct gat caa gac aag atg gag gaa gtg      924
 Ala Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp Lys Met Glu Glu Val
             275                 280                 285

 gaa gcc atg ctg ctc cca gag acc ctg aag cgg tgg aga gac tct ctg      972
 Glu Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser Leu
         290                 295                 300

 gag ttc aga gag ata ggt gag ctc tac ctg cca aag ttt tcc atc tcg     1020
 Glu Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser
     305                 310                 315

 agg gac tat aac ctg aac gac ata ctt ctc cag ctg ggc att gag gaa     1068
 Arg Asp Tyr Asn Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile Glu Glu
 320                 325                 330                 335

 gcc ttc acc agc aag gct gac ctg tca ggg atc aca ggg gcc agg aac     1116
 Ala Phe Thr Ser Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala Arg Asn
                 340                 345                 350

 cta gca gtc tcc cag gtg gtc cat aag gct gtg ctt gat gta ttt gag     1164
 Leu Ala Val Ser Gln Val Val His Lys Ala Val Leu Asp Val Phe Glu
             355                 360                 365

 gag ggc aca gaa gca tct gct gcc aca gca gtc agg ccc ttc ctg atg     1212
 Glu Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Arg Pro Phe Leu Met
         370                 375                 380

 atc att gtc cct aca gac acc cag aac atc ttc ttc atg agc aaa gtc     1260
 Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys Val
     385                 390                 395

 acc aat ccc aag caa gcc tag ag cttgccatca agcagtgggg ctctcagtaa     1313
 Thr Asn Pro Lys Gln Ala 
 400                 405

 ggaacttgga atgcaagctg gatgcctggg tctctgggca cagcctggcc cctgtgcacc   1373

 gagtggccat ggcatgtgtg gccctgtctg cttatccttg gaaggtgaca gcgattccct   1433

 gtgtagctct cacatgcaca ggggcccatg gactcttcag tctggagggt cctgggcctc   1493

 ctgacagcaa taaataattt cgttggaaaa aaaaaa                             1529




      <210> 667
      <211> 2951
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (303)..(2822)

      <400> 667
 agcggagggg ttaccccttc aatcttaagc aggatattct aggatctctc agtctcacag     60

 ccttgcccac caataaccag cagaaagcgg ttcgacaatg ggtccttctt tgggcccctc    120

 ctgcgatgcc cgcggactgg acggctgagt ctggctacgc gggcctccgc gggagcgcga    180

 ccgggccaat caagagcttg gcgtatttta caaactgaga aagtagctcc agcagcaccc    240

 gagagggtca ggagaaaagc ggaggaagct gggtaggccc tgaggggcct cggtaagcca    300

 tc   atg acc acc cgg caa gcc acg aag gat ccc ctc ctc cgg ggt gta     347
      Met Thr Thr Arg Gln Ala Thr Lys Asp Pro Leu Leu Arg Gly Val
        1               5                  10                  15

 tct cct acc cct agc aag att ccg gta cgc tct cag aaa cgc acg cct      395
 Ser Pro Thr Pro Ser Lys Ile Pro Val Arg Ser Gln Lys Arg Thr Pro
                  20                  25                  30

 ttc ccc act gtt aca tcg tgc gcc gtg gac cag gag aac caa gat cca      443
 Phe Pro Thr Val Thr Ser Cys Ala Val Asp Gln Glu Asn Gln Asp Pro
              35                  40                  45

 agg aga tgg gtg cag aaa cca ccg ctc aat att caa cgc ccc ctc gtt      491
 Arg Arg Trp Val Gln Lys Pro Pro Leu Asn Ile Gln Arg Pro Leu Val
          50                  55                  60

 gat tca gca ggc ccc agg ccg aaa gcc agg cac cag gca gag aca tca      539
 Asp Ser Ala Gly Pro Arg Pro Lys Ala Arg His Gln Ala Glu Thr Ser
      65                  70                  75

 caa aga ttg gtg ggg atc agt cag cct cgg aac ccc ttg gaa gag ctc      587
 Gln Arg Leu Val Gly Ile Ser Gln Pro Arg Asn Pro Leu Glu Glu Leu
  80                  85                  90                  95

 agg cct agc cct agg ggt caa aat gtg ggg cct ggg ccc cct gcc cag      635
 Arg Pro Ser Pro Arg Gly Gln Asn Val Gly Pro Gly Pro Pro Ala Gln
                 100                 105                 110

 aca gag gct cca ggg acc ata gag ttt gtg gct gac cct gca gcc ctg      683
 Thr Glu Ala Pro Gly Thr Ile Glu Phe Val Ala Asp Pro Ala Ala Leu
             115                 120                 125

 gcc acc atc ctg tca ggt gag ggt gtg aag agc tgt cac ctg ggg cgc      731
 Ala Thr Ile Leu Ser Gly Glu Gly Val Lys Ser Cys His Leu Gly Arg
         130                 135                 140

 cag cct agt ctg gct aaa aga gta ctg gtt cga gga agt cag gga ggc      779
 Gln Pro Ser Leu Ala Lys Arg Val Leu Val Arg Gly Ser Gln Gly Gly
     145                 150                 155

 acc acc cag agg gtc cag ggt gtt cgg gcc tct gca tat ttg gcc ccc      827
 Thr Thr Gln Arg Val Gln Gly Val Arg Ala Ser Ala Tyr Leu Ala Pro
 160                 165                 170                 175

 aga acc ccc acc cac cga ctg gac cct gcc agg gct tcc tgc ttc tct      875
 Arg Thr Pro Thr His Arg Leu Asp Pro Ala Arg Ala Ser Cys Phe Ser
                 180                 185                 190

 agg ctg gag gga cca gga cct cga ggc cgg aca ttg tgc ccc cag agg      923
 Arg Leu Glu Gly Pro Gly Pro Arg Gly Arg Thr Leu Cys Pro Gln Arg
             195                 200                 205

 cta cag gct ctg att tca cct tca gga cct tcc ttt cac cct tcc act      971
 Leu Gln Ala Leu Ile Ser Pro Ser Gly Pro Ser Phe His Pro Ser Thr
         210                 215                 220

 cgc ccc agt ttc cag gag cta aga agg gag aca gct ggc agc agc cgg     1019
 Arg Pro Ser Phe Gln Glu Leu Arg Arg Glu Thr Ala Gly Ser Ser Arg
     225                 230                 235

 act tca gtg agc cag gcc tca gga ttg ctc ctg gag acc cca gtc cag     1067
 Thr Ser Val Ser Gln Ala Ser Gly Leu Leu Leu Glu Thr Pro Val Gln
 240                 245                 250                 255

 cct gct ttc tct ctt cct aaa gga gaa cgc gag gtt gtc act cac tca     1115
 Pro Ala Phe Ser Leu Pro Lys Gly Glu Arg Glu Val Val Thr His Ser
                 260                 265                 270

 gat gaa gga ggt gtg gcc tct ctt ggt ctg gcc cag cga gta cca tta     1163
 Asp Glu Gly Gly Val Ala Ser Leu Gly Leu Ala Gln Arg Val Pro Leu
             275                 280                 285

 aga gaa aac cga gaa atg tca cat acc agg gac agc cat gac tcc cac     1211
 Arg Glu Asn Arg Glu Met Ser His Thr Arg Asp Ser His Asp Ser His
         290                 295                 300

 ctg atg ccc tcc cct gcc cct gtg gcc cag ccc ttg cct ggc cat gtg     1259
 Leu Met Pro Ser Pro Ala Pro Val Ala Gln Pro Leu Pro Gly His Val
     305                 310                 315

 gtg cca tgt cca tca ccc ttt gga cgg gct cag cgt gta ccc tcc cca     1307
 Val Pro Cys Pro Ser Pro Phe Gly Arg Ala Gln Arg Val Pro Ser Pro
 320                 325                 330                 335

 ggc cct cca act ctg acc tca tat tca gtg ttg cgg cgt ctc acc gtt     1355
 Gly Pro Pro Thr Leu Thr Ser Tyr Ser Val Leu Arg Arg Leu Thr Val
                 340                 345                 350

 caa cct aaa acc cgg ttc aca ccc atg cca tca acc ccc aga gtt cag     1403
 Gln Pro Lys Thr Arg Phe Thr Pro Met Pro Ser Thr Pro Arg Val Gln
             355                 360                 365

 cag gcc cag tgg ctg cgt ggt gtc tcc cct cag tcc tgc tct gaa gat     1451
 Gln Ala Gln Trp Leu Arg Gly Val Ser Pro Gln Ser Cys Ser Glu Asp
         370                 375                 380

 cct gcc ctg ccc tgg gag cag gtt gcc gtc cgg ttg ttt gac cag gag     1499
 Pro Ala Leu Pro Trp Glu Gln Val Ala Val Arg Leu Phe Asp Gln Glu
     385                 390                 395

 agt tgt ata agg tca ctg gag ggt tct ggg aaa cca ccg gtg gcc act     1547
 Ser Cys Ile Arg Ser Leu Glu Gly Ser Gly Lys Pro Pro Val Ala Thr
 400                 405                 410                 415

 cct tct gga ccc cac tct aac aga acc ccc agc ctc cag gag gtg aag     1595
 Pro Ser Gly Pro His Ser Asn Arg Thr Pro Ser Leu Gln Glu Val Lys
                 420                 425                 430

 att caa cgc atc ggt atc ctg caa cag ctg ttg aga cag gaa gta gag     1643
 Ile Gln Arg Ile Gly Ile Leu Gln Gln Leu Leu Arg Gln Glu Val Glu
             435                 440                 445

 ggg ctg gta ggg ggc cag tgt gtc cct ctt aat gga ggc tct tct ctg     1691
 Gly Leu Val Gly Gly Gln Cys Val Pro Leu Asn Gly Gly Ser Ser Leu
         450                 455                 460

 gat atg gtt gaa ctt cag ccc ctg ctg act gag att tct aga act ctg     1739
 Asp Met Val Glu Leu Gln Pro Leu Leu Thr Glu Ile Ser Arg Thr Leu
     465                 470                 475

 aat gcc aca gag cat aac tct ggg act tcc cac ctt cct gga ctg tta     1787
 Asn Ala Thr Glu His Asn Ser Gly Thr Ser His Leu Pro Gly Leu Leu
 480                 485                 490                 495

 aaa cac tca ggg ctg cca aag ccc tgt ctt cca gag gag tgc ggg gaa     1835
 Lys His Ser Gly Leu Pro Lys Pro Cys Leu Pro Glu Glu Cys Gly Glu
                 500                 505                 510

 cca cag ccc tgc cct ccg gca gag cct ggg ccc cca gag gcc ttc tgt     1883
 Pro Gln Pro Cys Pro Pro Ala Glu Pro Gly Pro Pro Glu Ala Phe Cys
             515                 520                 525

 agg agt gag cct gag ata cca gag ccc tcc ctc cag gaa cag ctt gaa     1931
 Arg Ser Glu Pro Glu Ile Pro Glu Pro Ser Leu Gln Glu Gln Leu Glu
         530                 535                 540

 gta cca gag ccc tac cct cca gca gaa ccc agg ccc cta gag tcc tgc     1979
 Val Pro Glu Pro Tyr Pro Pro Ala Glu Pro Arg Pro Leu Glu Ser Cys
     545                 550                 555

 tgt agg agt gag cct gag ata ccg gag tcc tct cgc cag gaa cag ctt     2027
 Cys Arg Ser Glu Pro Glu Ile Pro Glu Ser Ser Arg Gln Glu Gln Leu
 560                 565                 570                 575

 gag gaa cag ctt gag gta cct gag ccc tgc cct cca gca gaa ccc ggg     2075
 Glu Glu Gln Leu Glu Val Pro Glu Pro Cys Pro Pro Ala Glu Pro Gly
                 580                 585                 590

 ccc ctt cag ccc agc acc cag ggg cag tct gga ccc cca ggg ccc tgc     2123
 Pro Leu Gln Pro Ser Thr Gln Gly Gln Ser Gly Pro Pro Gly Pro Cys
             595                 600                 605

 cct agg gta gag ctg ggg gca tca gag ccc tgc acc ctg gaa cat aga     2171
 Pro Arg Val Glu Leu Gly Ala Ser Glu Pro Cys Thr Leu Glu His Arg
         610                 615                 620

 agt cta gag tcc agt cta cca ccc tgc tgc agt cag tgg gct cca gca     2219
 Ser Leu Glu Ser Ser Leu Pro Pro Cys Cys Ser Gln Trp Ala Pro Ala
     625                 630                 635

 acc acc agc ctg atc ttt tct tcc caa gac ccg ctt tgt gcc agc ccc     2267
 Thr Thr Ser Leu Ile Phe Ser Ser Gln Asp Pro Leu Cys Ala Ser Pro
 640                 645                 650                 655

 cct atc tgc tca ctc cag tct ttg aga ccc cca gca ggc cag gca ggt     2315
 Pro Ile Cys Ser Leu Gln Ser Leu Arg Pro Pro Ala Gly Gln Ala Gly
                 660                 665                 670

 aag gag ttg gct ggg aag gag tgt gaa cac aag agg tcc tca cct cac     2363
 Lys Glu Leu Ala Gly Lys Glu Cys Glu His Lys Arg Ser Ser Pro His
             675                 680                 685

 tgt gag ctg cac acc tgc cct gcc cct acc cca ggc aat ctc atg ctt     2411
 Cys Glu Leu His Thr Cys Pro Ala Pro Thr Pro Gly Asn Leu Met Leu
         690                 695                 700

 cca cac ctt cca ccc tgg ccc agc ctg gct ctc cct cag gaa gag ggg     2459
 Pro His Leu Pro Pro Trp Pro Ser Leu Ala Leu Pro Gln Glu Glu Gly
     705                 710                 715

 agg ggc tgc act tcc agc cct gtg ctc cta att ggc ttg gcc gtt ggt     2507
 Arg Gly Cys Thr Ser Ser Pro Val Leu Leu Ile Gly Leu Ala Val Gly
 720                 725                 730                 735

 ggg gga gga gga gag gac agt aca tgg tgg aag tat agg acc cca gac     2555
 Gly Gly Gly Gly Glu Asp Ser Thr Trp Trp Lys Tyr Arg Thr Pro Asp
                 740                 745                 750

 ctc cct cta aat ttt cca tgc ccc tca ggc ctc agc aat ctg gcc cct     2603
 Leu Pro Leu Asn Phe Pro Cys Pro Ser Gly Leu Ser Asn Leu Ala Pro
             755                 760                 765

 cga acc cta gcc ctg agg gag cgc ctc aaa tcg tgt tta acc gcc atc     2651
 Arg Thr Leu Ala Leu Arg Glu Arg Leu Lys Ser Cys Leu Thr Ala Ile
         770                 775                 780

 cac tgc ttc cac gag gct cgt ctg gac gat gag tgt gcc ttt tac acc     2699
 His Cys Phe His Glu Ala Arg Leu Asp Asp Glu Cys Ala Phe Tyr Thr
     785                 790                 795

 agc cga gcc cct ccc tca ggc ccc acc cgg gtc tgc acc aac cct gtg     2747
 Ser Arg Ala Pro Pro Ser Gly Pro Thr Arg Val Cys Thr Asn Pro Val
 800                 805                 810                 815

 gct aca tta ctc gaa tgg cag gat gcc ctg tgt ttc att cca gtt ggt     2795
 Ala Thr Leu Leu Glu Trp Gln Asp Ala Leu Cys Phe Ile Pro Val Gly
                 820                 825                 830

 tct gct gcc ccc cag ggc tct cca tga tgaga caaccactcc tgccctgccg     2847
 Ser Ala Ala Pro Gln Gly Ser Pro 
             835

 tacttcttcc ttttagccct tatttattgt cggtctgccc atgggactgg gagccgccca   2907

 cttttgtcct caataaagtt tctaaagtaa aaaaaaaaaa aaaa                    2951




      <210> 668
      <211> 2058
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (161)..(1117)

      <400> 668
 aaggatcctt aattaaatta atcccccccc ccccccggga tgggcaaggc ggccgcgatg     60

 gctcgagctc gggcggtggc ggcggtggcc ggaggcggcg gtgcctcctc ctcctcgccc    120

 cggcgccggc ggtgatccga gcgagcggcc gcggcccccg  atg aga ctg ctg gcg     175
                                              Met Arg Leu Leu Ala
                                                1               5

 ggc tgg ctg tgc ctg agc ctg gcg tcc gtg tgg ctg gcg cgg agg atg      223
 Gly Trp Leu Cys Leu Ser Leu Ala Ser Val Trp Leu Ala Arg Arg Met
                  10                  15                  20

 tgg acg ctg cgg agc ccg ctc acc cgc tcc ctg tac gtg aac atg act      271
 Trp Thr Leu Arg Ser Pro Leu Thr Arg Ser Leu Tyr Val Asn Met Thr
              25                  30                  35

 agc ggc ccg ggt ggg ccg gcg gcg gcc gcg ggc ggc agg aag gag aac      319
 Ser Gly Pro Gly Gly Pro Ala Ala Ala Ala Gly Gly Arg Lys Glu Asn
          40                  45                  50

 cac cag tgg tat gtg tgc aac aga gag aaa tta tgc gaa tca ctc cag      367
 His Gln Trp Tyr Val Cys Asn Arg Glu Lys Leu Cys Glu Ser Leu Gln
      55                  60                  65

 gct gtc ttt gtt cag agt tac ctt gat caa gga aca cag atc ttc tta      415
 Ala Val Phe Val Gln Ser Tyr Leu Asp Gln Gly Thr Gln Ile Phe Leu
  70                  75                  80                  85

 aac aac agc att gag aaa tcg ggc tgg cta ttt atc caa tta tat cat      463
 Asn Asn Ser Ile Glu Lys Ser Gly Trp Leu Phe Ile Gln Leu Tyr His
                  90                  95                 100

 tct ttt gtg tca tct gtt ttt agc ctg ttt atg tct aga aca tct atc      511
 Ser Phe Val Ser Ser Val Phe Ser Leu Phe Met Ser Arg Thr Ser Ile
             105                 110                 115

 aat ggg ttg cta gga aga ggc tca atg ttt gtg ttt tca cca gat cag      559
 Asn Gly Leu Leu Gly Arg Gly Ser Met Phe Val Phe Ser Pro Asp Gln
         120                 125                 130

 ttt cag aga ctg ctt aaa att aat cca gac tgg aaa acc cac aga ctt      607
 Phe Gln Arg Leu Leu Lys Ile Asn Pro Asp Trp Lys Thr His Arg Leu
     135                 140                 145

 ctt gat tta ggt gct gga gat gga gaa gtc aca aaa atc atg agc cct      655
 Leu Asp Leu Gly Ala Gly Asp Gly Glu Val Thr Lys Ile Met Ser Pro
 150                 155                 160                 165

 cat ttt gaa gaa atc tat gcc act gag ctt tct gaa act atg ata tgg      703
 His Phe Glu Glu Ile Tyr Ala Thr Glu Leu Ser Glu Thr Met Ile Trp
                 170                 175                 180

 cag ctt cag aaa aag aaa tac aga gtc ctt ggt ata aat gaa tgg cag      751
 Gln Leu Gln Lys Lys Lys Tyr Arg Val Leu Gly Ile Asn Glu Trp Gln
             185                 190                 195

 aat acg ggg ttc cag tat gat gtc atc agc tgc ctg aac ttg ctg gac      799
 Asn Thr Gly Phe Gln Tyr Asp Val Ile Ser Cys Leu Asn Leu Leu Asp
         200                 205                 210

 cgc tgt gat cag ccc ctg act ttg tta aaa gat atc aga agt gtc ttg      847
 Arg Cys Asp Gln Pro Leu Thr Leu Leu Lys Asp Ile Arg Ser Val Leu
     215                 220                 225

 gag cca act aga ggc agg gtc atc ctt gcc ctt gtc ctc ccc ttt cat      895
 Glu Pro Thr Arg Gly Arg Val Ile Leu Ala Leu Val Leu Pro Phe His
 230                 235                 240                 245

 ccc tat gtg gaa aac gta ggt ggc aag tgg gag aaa cca tca gaa att      943
 Pro Tyr Val Glu Asn Val Gly Gly Lys Trp Glu Lys Pro Ser Glu Ile
                 250                 255                 260

 ttg gaa atc aaa gga cag aac tgg gaa gaa caa gtg aat agt ctg cct      991
 Leu Glu Ile Lys Gly Gln Asn Trp Glu Glu Gln Val Asn Ser Leu Pro
             265                 270                 275

 gaa gtt ttc aga aaa gct ggt ttt gtt atc gaa gct ttc acc aga cta     1039
 Glu Val Phe Arg Lys Ala Gly Phe Val Ile Glu Ala Phe Thr Arg Leu
         280                 285                 290

 cca tac ctg tgt gaa ggc gac atg tat aat gac tac tac gtt ctg gat     1087
 Pro Tyr Leu Cys Glu Gly Asp Met Tyr Asn Asp Tyr Tyr Val Leu Asp
     295                 300                 305

 gac gct gtc ttt gtt ctc aaa cca gta taa a cacgtggagg tcgaagtctt     1138
 Asp Ala Val Phe Val Leu Lys Pro Val 
 310                 315

 cagagtccgc accctccggg atgtgccctt ggaagagggt ctgtgttcac aattacgtga   1198

 agggaggacc cttggggacc gccattctaa atatcatgta ggaatttaaa aagccaaaat   1258

 actaattatt tctttgtagt gtgtaaagga atgtttttaa aagacaaaaa cccaactctt   1318

 tgtggatttt tatcaactct ttactcagag ccactctcca atgcaggtca cactccaatt   1378

 atgatggaag atatttttta tacttaattg cagtagggac tcattcccag acaaagcaat   1438

 agtcacgact tcatggaacc aatcaatgga ttgttttttg aagactggca ataaagctgt   1498

 ccattcaatt ccaaatactg gttttaaggt atagccactg atattctttc atgtttagaa   1558

 attctttctg ttattattca agaaaatgtt tttaatcatg ctaataaact tttttggaga   1618

 tgactttggc atcatgtttg aattcatata aagctcccct agcatttttt attggtttgg   1678

 cttcaggagt acccaaatag tagcattatg agaatgacgc agaccttttg ggcaaaaata   1738

 tgctttgaca gtggtctccc acctatttgt tccactgtct gccttcccct ggttacttaa   1798

 aattcatcag cttgtccaac tggaccttct ttccttcctg ctgaagttga tttgaagtaa   1858

 aaccttagat ttgatgttaa aacagttgtc aaatctgttg gtaaataaga tttgaaggac   1918

 cctactctgt ctcccttgaa aaaggggagg aatgtcagtg ttactgtttt tggaaaaagt   1978

 agatttttaa accgagtttg gaaatggtaa gtatgcaaag gtccgtgggg gcaatctcaa   2038

 aaacgtgcaa aaaaaaaaaa                                               2058




      <210> 669
      <211> 705
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(325)

      <400> 669
 gcacgagcaa gaagggtagg agagaaaagc c   atg gcc gac aag gtc ctg aag      52
                                      Met Ala Asp Lys Val Leu Lys
                                        1               5

 gag aag aga aag ctg ttt atc cat tcc atg ggt gaa ggt aca ata aat      100
 Glu Lys Arg Lys Leu Phe Ile His Ser Met Gly Glu Gly Thr Ile Asn
          10                  15                  20

 ggc tta ctg gat gaa tta tta cag aca agg gtg ctg aac cag gaa gag      148
 Gly Leu Leu Asp Glu Leu Leu Gln Thr Arg Val Leu Asn Gln Glu Glu
      25                  30                  35

 atg gag aaa gta aaa cgt gaa aat gct aca gtt atg gat aag acc cga      196
 Met Glu Lys Val Lys Arg Glu Asn Ala Thr Val Met Asp Lys Thr Arg
  40                  45                  50                  55

 gct ttg att gac tcc gtt att ccg aaa ggg gca cag gca tgc caa att      244
 Ala Leu Ile Asp Ser Val Ile Pro Lys Gly Ala Gln Ala Cys Gln Ile
                  60                  65                  70

 tgc atc aca tac att tgt gaa gaa gac agt tac ctg gca gag acg ctg      292
 Cys Ile Thr Tyr Ile Cys Glu Glu Asp Ser Tyr Leu Ala Glu Thr Leu
              75                  80                  85

 gga ctc tca gca ggt ccg ata cct gga aat tag cttagtac acaagactcc      343
 Gly Leu Ser Ala Gly Pro Ile Pro Gly Asn 
          90                  95

 caattactat tttcttcctt cccagctctt caggcagtgc aggacaaccc agctatgccc    403

 acatgctcaa gcccagaagg cagaatcaag ctttgctttc tagaagacgc tcaaaggata    463

 tggaaacaaa agttgcagag gtgccatgtt cagaatacaa taataaagtg gagtgaaaga    523

 tatacttcag gcagttttga aatgcagtgg ctttttctta gaaccaattt tattgagcgg    583

 ttctggagga acatacttct gctccccttg cataaaggat ctctatatcc tagaatccca    643

 ggtttaggta aagagatgcc aactggaact cataaattat catagtattc aaaaaaaaaa    703

 aa                                                                   705




      <210> 670
      <211> 429
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(351)

      <400> 670
 attcctggtg tctctccatc tttccctctc tgtctctctg tgtctccagc tctctgggca     60

 gcgccggaag cc    atg ggc tca tct gtg ttg agc atc tgg atc ctc tca     108
                  Met Gly Ser Ser Val Leu Ser Ile Trp Ile Leu Ser
                    1               5                  10

 ccc tcc atc tac ccc atc ctg tct ccc ctc gcc atg ccc tgc ctc tcc      156
 Pro Ser Ile Tyr Pro Ile Leu Ser Pro Leu Ala Met Pro Cys Leu Ser
          15                  20                  25

 agg acc gac ctc atc agg gtc cgc agg atc cag ggc gca tgg ccc agc      204
 Arg Thr Asp Leu Ile Arg Val Arg Arg Ile Gln Gly Ala Trp Pro Ser
      30                  35                  40

 gag ggc acc gcc tcg tcc atc aga ggg tgg gtc ttg aca aag ttg agg      252
 Glu Gly Thr Ala Ser Ser Ile Arg Gly Trp Val Leu Thr Lys Leu Arg
  45                  50                  55                  60

 atg tca tcc ggc aag gcg ctg gag gca ttg tac tgc atc ccg ggg gct      300
 Met Ser Ser Gly Lys Ala Leu Glu Ala Leu Tyr Cys Ile Pro Gly Ala
                  65                  70                  75

 gcg cag cac ccg ggc ctg ggg gtg aca agg gtg tgg tca gga cga acg      348
 Ala Gln His Pro Gly Leu Gly Val Thr Arg Val Trp Ser Gly Arg Thr
              80                  85                  90

 taa aggt tctcataaag gggcctgatt caccagaggt acccattgct ttgcccaacg      405
 


 accctcaggt tttttgtttg attg                                           429




      <210> 671
      <211> 845
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (99)..(815)

      <400> 671
 gtggacagac tgctttgctc gttgttgctc ttcggaggcg gcgatccccg aaggcgagct     60

 gaaatacggc tgcaggctac aatttgcagc cgacgatt    atg gaa gac ggc aag     113
                                              Met Glu Asp Gly Lys
                                                1               5

 cgg gag agg tgg ccc acc ctc atg gag cgc ttg tgc tcg gat ggc ttc      161
 Arg Glu Arg Trp Pro Thr Leu Met Glu Arg Leu Cys Ser Asp Gly Phe
                  10                  15                  20

 gca ttt ccc caa tac ccc att aaa ccg tat cat ctg aat agg atc cac      209
 Ala Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His Leu Asn Arg Ile His
              25                  30                  35

 aga gct gtc tta cat ggt aat cta gag aaa ctg aag tac ctt ctg ctc      257
 Arg Ala Val Leu His Gly Asn Leu Glu Lys Leu Lys Tyr Leu Leu Leu
          40                  45                  50

 acg tat tat gac gcc aat aag aga gac agg aag gaa agg acc gcc cta      305
 Thr Tyr Tyr Asp Ala Asn Lys Arg Asp Arg Lys Glu Arg Thr Ala Leu
      55                  60                  65

 cat ttg gcc tgt gcc act ggc caa ccg gaa atg gta cat ctc ctg gtg      353
 His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met Val His Leu Leu Val
  70                  75                  80                  85

 tcc aga aga tgt gag ctt aac ctc tgc gac cgt gaa gac agg aca cct      401
 Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg Glu Asp Arg Thr Pro
                  90                  95                 100

 ctg atc aag gct gta caa ctg agg cag gag gct tgt gca act ctt ctg      449
 Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala Cys Ala Thr Leu Leu
             105                 110                 115

 ctg caa aat ggc gcc aat cca aat att acg gat ttc ttt gga agg act      497
 Leu Gln Asn Gly Ala Asn Pro Asn Ile Thr Asp Phe Phe Gly Arg Thr
         120                 125                 130

 gct ctg cac tac gct gtg tat aat gaa gat aca tcc atg ata gaa aaa      545
 Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr Ser Met Ile Glu Lys
     135                 140                 145

 ctt ctt tca cat ggt aca aat att gaa gaa tgc agc aag tgt gaa tat      593
 Leu Leu Ser His Gly Thr Asn Ile Glu Glu Cys Ser Lys Cys Glu Tyr
 150                 155                 160                 165

 cag cca ctg tta ttt gct gtg agt cga aga aaa gtg aaa atg gtg gaa      641
 Gln Pro Leu Leu Phe Ala Val Ser Arg Arg Lys Val Lys Met Val Glu
                 170                 175                 180

 ttt tta tta aag aaa aaa gca aat gta aat gcc att gat tat ctt ggc      689
 Phe Leu Leu Lys Lys Lys Ala Asn Val Asn Ala Ile Asp Tyr Leu Gly
             185                 190                 195

 aga tca gcc ctc ata cat gct gtt act ctt gga gaa aaa gat ata gtc      737
 Arg Ser Ala Leu Ile His Ala Val Thr Leu Gly Glu Lys Asp Ile Val
         200                 205                 210

 att ctt ctt ctg cag cac aat att gat gtg ctt tct cga gat gcg ttt      785
 Ile Leu Leu Leu Gln His Asn Ile Asp Val Leu Ser Arg Asp Ala Phe
     215                 220                 225

 cga aag att tgc agg aga tta tgc cat tga g gctaagaata gagtgtaagt      836
 Arg Lys Ile Cys Arg Arg Leu Cys His 
 230                 235

 ctttacata                                                            845




      <210> 672
      <211> 7321
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(7167)

      <400> 672
  atg tct ggc ggc gcc gca gag aag cag agc agc act ccc ggt tcc ctg      48
  Met Ser Gly Gly Ala Ala Glu Lys Gln Ser Ser Thr Pro Gly Ser Leu
    1               5                  10                  15

 ttc ctc tcg ccg ccg gct cct gcc ccc aag aat ggc tcc agc tcc gat       96
 Phe Leu Ser Pro Pro Ala Pro Ala Pro Lys Asn Gly Ser Ser Ser Asp
              20                  25                  30

 tcc tcc gtg ggg gag aaa ctg gga gcc gcg gcc gcc gac gct gtg acc      144
 Ser Ser Val Gly Glu Lys Leu Gly Ala Ala Ala Ala Asp Ala Val Thr
          35                  40                  45

 ggc agg acc gag gag tac agg cgc cgc cgc cac act atg gac aag gac      192
 Gly Arg Thr Glu Glu Tyr Arg Arg Arg Arg His Thr Met Asp Lys Asp
      50                  55                  60

 agc cgt ggg gcg gcc gcg acc act acc acc act gag cac cgc ttc ttc      240
 Ser Arg Gly Ala Ala Ala Thr Thr Thr Thr Thr Glu His Arg Phe Phe
  65                  70                  75                  80

 cgc cgg agc gtc atc tgc gac tcc aat gcc act gca ctg gag ctt ccc      288
 Arg Arg Ser Val Ile Cys Asp Ser Asn Ala Thr Ala Leu Glu Leu Pro
                  85                  90                  95

 ggc ctt cct ctt tcc ctg ccc cag ccc agc atc ccc gcg gct gtc ccg      336
 Gly Leu Pro Leu Ser Leu Pro Gln Pro Ser Ile Pro Ala Ala Val Pro
             100                 105                 110

 cag agt gct cca ccg gag ccc cac cgg gaa gag acc gtg acc gcc acc      384
 Gln Ser Ala Pro Pro Glu Pro His Arg Glu Glu Thr Val Thr Ala Thr
         115                 120                 125

 gcc act tcc cag gta gcc cag cag cct cca gcc gct gcc gcc cct ggg      432
 Ala Thr Ser Gln Val Ala Gln Gln Pro Pro Ala Ala Ala Ala Pro Gly
     130                 135                 140

 gaa cag gcc gtc gcg ggc cct gcc ccc tcg act gtc ccc agc agt acc      480
 Glu Gln Ala Val Ala Gly Pro Ala Pro Ser Thr Val Pro Ser Ser Thr
 145                 150                 155                 160

 agc aaa gac cgc cca gtg tcc cag cct agc ctt gtg ggg agc aaa gag      528
 Ser Lys Asp Arg Pro Val Ser Gln Pro Ser Leu Val Gly Ser Lys Glu
                 165                 170                 175

 gag ccg ccg ccg gcg aga agt ggc agc ggc ggc ggc agc gcc aag gag      576
 Glu Pro Pro Pro Ala Arg Ser Gly Ser Gly Gly Gly Ser Ala Lys Glu
             180                 185                 190

 cca cag gag gaa cgg agc cag cag cag gat gat atc gaa gag ctg gag      624
 Pro Gln Glu Glu Arg Ser Gln Gln Gln Asp Asp Ile Glu Glu Leu Glu
         195                 200                 205

 acc aag gcc gtg gga atg tct aac gat ggc cgc ttt ctc aag ttt gac      672
 Thr Lys Ala Val Gly Met Ser Asn Asp Gly Arg Phe Leu Lys Phe Asp
     210                 215                 220

 atc gaa atc ggc aga ggc tcc ttt aag acg gtc tac aaa ggt ctg gac      720
 Ile Glu Ile Gly Arg Gly Ser Phe Lys Thr Val Tyr Lys Gly Leu Asp
 225                 230                 235                 240

 act gaa acc acc gtg gaa gtc gcc tgg tgt gaa ctg cag gat cga aaa      768
 Thr Glu Thr Thr Val Glu Val Ala Trp Cys Glu Leu Gln Asp Arg Lys
                 245                 250                 255

 tta aca aag tct gag agg cag aga ttt aaa gaa gaa gct gaa atg tta      816
 Leu Thr Lys Ser Glu Arg Gln Arg Phe Lys Glu Glu Ala Glu Met Leu
             260                 265                 270

 aaa ggt ctt cag cat ccc aat att gtt aga ttt tat gat tcc tgg gaa      864
 Lys Gly Leu Gln His Pro Asn Ile Val Arg Phe Tyr Asp Ser Trp Glu
         275                 280                 285

 tcc aca gta aaa gga aag aag tgc att gtt ttg gtg act gaa ctt atg      912
 Ser Thr Val Lys Gly Lys Lys Cys Ile Val Leu Val Thr Glu Leu Met
     290                 295                 300

 acg tct gga aca ctt aaa acg tat ctg aaa agg ttt aaa gtg atg aag      960
 Thr Ser Gly Thr Leu Lys Thr Tyr Leu Lys Arg Phe Lys Val Met Lys
 305                 310                 315                 320

 atc aaa gtt cta aga agc tgg tgc cgt cag atc ctt aaa ggt ctt cag     1008
 Ile Lys Val Leu Arg Ser Trp Cys Arg Gln Ile Leu Lys Gly Leu Gln
                 325                 330                 335

 ttt ctt cat act cga act cca cct atc att cac cgc gat ctt aaa tgt     1056
 Phe Leu His Thr Arg Thr Pro Pro Ile Ile His Arg Asp Leu Lys Cys
             340                 345                 350

 gac aac atc ttt atc acc ggc cct act ggc tca gtc aag att gga gac     1104
 Asp Asn Ile Phe Ile Thr Gly Pro Thr Gly Ser Val Lys Ile Gly Asp
         355                 360                 365

 ctc ggt ctg gca acc ctg aag cgg gct tct ttt gcc aag agt gtg ata     1152
 Leu Gly Leu Ala Thr Leu Lys Arg Ala Ser Phe Ala Lys Ser Val Ile
     370                 375                 380

 ggt acc cca gag ttc atg gcc cct gag atg tat gag gag aaa tat gat     1200
 Gly Thr Pro Glu Phe Met Ala Pro Glu Met Tyr Glu Glu Lys Tyr Asp
 385                 390                 395                 400

 gaa tcc gtt gac gtt tat gct ttt ggg atg tgc atg ctt gag atg gct     1248
 Glu Ser Val Asp Val Tyr Ala Phe Gly Met Cys Met Leu Glu Met Ala
                 405                 410                 415

 aca tct gaa tat cct tac tcg gag tgc caa aat gct gcg cag atc tac     1296
 Thr Ser Glu Tyr Pro Tyr Ser Glu Cys Gln Asn Ala Ala Gln Ile Tyr
             420                 425                 430

 cgt cgc gtg acc agt ggg gtg aag cca gcc agt ttt gac aaa gta gca     1344
 Arg Arg Val Thr Ser Gly Val Lys Pro Ala Ser Phe Asp Lys Val Ala
         435                 440                 445

 att cct gaa gtg aag gaa att att gaa gga tgc ata cga caa aac aaa     1392
 Ile Pro Glu Val Lys Glu Ile Ile Glu Gly Cys Ile Arg Gln Asn Lys
     450                 455                 460

 gat gaa aga tat tcc atc aaa gac ctt ttg aac cat gcc ttc ttc caa     1440
 Asp Glu Arg Tyr Ser Ile Lys Asp Leu Leu Asn His Ala Phe Phe Gln
 465                 470                 475                 480

 gag gaa aca gga gta cgg gta gaa tta gca gaa gaa gat gat gga gaa     1488
 Glu Glu Thr Gly Val Arg Val Glu Leu Ala Glu Glu Asp Asp Gly Glu
                 485                 490                 495

 aaa ata gcc ata aaa tta tgg cta cgt att gaa gat att aag aaa tta     1536
 Lys Ile Ala Ile Lys Leu Trp Leu Arg Ile Glu Asp Ile Lys Lys Leu
             500                 505                 510

 aag gga aaa tac aaa gat aat gaa gct att gag ttt tct ttt gat tta     1584
 Lys Gly Lys Tyr Lys Asp Asn Glu Ala Ile Glu Phe Ser Phe Asp Leu
         515                 520                 525

 gag aga gat gtc cca gaa gat gtt gca caa gaa atg gta gag tct ggg     1632
 Glu Arg Asp Val Pro Glu Asp Val Ala Gln Glu Met Val Glu Ser Gly
     530                 535                 540

 tat gtc tgt gaa ggt gat cac aag acc atg gct aaa gct atc aaa gac     1680
 Tyr Val Cys Glu Gly Asp His Lys Thr Met Ala Lys Ala Ile Lys Asp
 545                 550                 555                 560

 aga gta tca tta att aag agg aaa cga gag cag cgg cag ttg gta cgg     1728
 Arg Val Ser Leu Ile Lys Arg Lys Arg Glu Gln Arg Gln Leu Val Arg
                 565                 570                 575

 gag gag caa gaa aaa aaa aag cag gaa gag agc agt ctc aaa cag cag     1776
 Glu Glu Gln Glu Lys Lys Lys Gln Glu Glu Ser Ser Leu Lys Gln Gln
             580                 585                 590

 gta gaa caa tcc agt gct tcc cag aca gga atc aag cag ctc cct tct     1824
 Val Glu Gln Ser Ser Ala Ser Gln Thr Gly Ile Lys Gln Leu Pro Ser
         595                 600                 605

 gct agc acc ggc ata cct act gct tct acc act tca gct tca gtt tct     1872
 Ala Ser Thr Gly Ile Pro Thr Ala Ser Thr Thr Ser Ala Ser Val Ser
     610                 615                 620

 aca caa gta gaa cct gaa gaa cct gag gca gat caa cat caa caa cta     1920
 Thr Gln Val Glu Pro Glu Glu Pro Glu Ala Asp Gln His Gln Gln Leu
 625                 630                 635                 640

 cag tac cag caa ccc agt ata tct gtg tta tct gat ggg acg gtt gac     1968
 Gln Tyr Gln Gln Pro Ser Ile Ser Val Leu Ser Asp Gly Thr Val Asp
                 645                 650                 655

 agt ggt cag gga tcc tct gtc ttc aca gaa tct cga gtg agc agc caa     2016
 Ser Gly Gln Gly Ser Ser Val Phe Thr Glu Ser Arg Val Ser Ser Gln
             660                 665                 670

 cag aca gtt tca tat ggt tcc caa cat gaa cag gca cat tct aca ggc     2064
 Gln Thr Val Ser Tyr Gly Ser Gln His Glu Gln Ala His Ser Thr Gly
         675                 680                 685

 aca gtc cca ggg cat ata cct tct act gtc caa gca cag tct cag ccc     2112
 Thr Val Pro Gly His Ile Pro Ser Thr Val Gln Ala Gln Ser Gln Pro
     690                 695                 700

 cat ggg gta tat cca ccc tca agt gtg gca cag ggg cag agc cag ggt     2160
 His Gly Val Tyr Pro Pro Ser Ser Val Ala Gln Gly Gln Ser Gln Gly
 705                 710                 715                 720

 cag cca tcc tca agt agc tta aca ggg gtt tca tct tcc caa ccc ata     2208
 Gln Pro Ser Ser Ser Ser Leu Thr Gly Val Ser Ser Ser Gln Pro Ile
                 725                 730                 735

 caa cat cct cag cag cag cag gga ata cag cag aca gcc cct cct caa     2256
 Gln His Pro Gln Gln Gln Gln Gly Ile Gln Gln Thr Ala Pro Pro Gln
             740                 745                 750

 cag aca gtg cag tat tca ctt tca cag aca tca acc tcc agt gag gcc     2304
 Gln Thr Val Gln Tyr Ser Leu Ser Gln Thr Ser Thr Ser Ser Glu Ala
         755                 760                 765

 act act gca cag cca gtg agt caa cct caa gct cca caa gtc ttg cct     2352
 Thr Thr Ala Gln Pro Val Ser Gln Pro Gln Ala Pro Gln Val Leu Pro
     770                 775                 780

 caa gta tca gct gga aaa cag ctt cca gtt tcc cag cca gta cca act     2400
 Gln Val Ser Ala Gly Lys Gln Leu Pro Val Ser Gln Pro Val Pro Thr
 785                 790                 795                 800

 atc caa ggc gaa cct cag atc cca gtt gcg aca caa ccc tcg gtt gtt     2448
 Ile Gln Gly Glu Pro Gln Ile Pro Val Ala Thr Gln Pro Ser Val Val
                 805                 810                 815

 cca gtc cac tct ggt gct cat ttc ctt cca gtg gga cag ccg ctc cct     2496
 Pro Val His Ser Gly Ala His Phe Leu Pro Val Gly Gln Pro Leu Pro
             820                 825                 830

 act ccc ttg ctc cct cag tac cct gtc tct cag att ccc ata tca act     2544
 Thr Pro Leu Leu Pro Gln Tyr Pro Val Ser Gln Ile Pro Ile Ser Thr
         835                 840                 845

 cct cat gtg tct acg gct cag aca ggt ttc tca tcc ctt ccc atc aca     2592
 Pro His Val Ser Thr Ala Gln Thr Gly Phe Ser Ser Leu Pro Ile Thr
     850                 855                 860

 atg gca gct ggc att act cag cct ctg ctc acg ttg gct tca tct gct     2640
 Met Ala Ala Gly Ile Thr Gln Pro Leu Leu Thr Leu Ala Ser Ser Ala
 865                 870                 875                 880

 aca aca gct gcg atc ccg ggg gta tca act gtg gtt cct agt cag ctt     2688
 Thr Thr Ala Ala Ile Pro Gly Val Ser Thr Val Val Pro Ser Gln Leu
                 885                 890                 895

 cca acc ctt ctg cag cct gtg act cag ctg cca agt cag gtt cac cca     2736
 Pro Thr Leu Leu Gln Pro Val Thr Gln Leu Pro Ser Gln Val His Pro
             900                 905                 910

 cag ctc cta caa cca gca gtt cag tcc atg gga ata cca gct aac ctt     2784
 Gln Leu Leu Gln Pro Ala Val Gln Ser Met Gly Ile Pro Ala Asn Leu
         915                 920                 925

 gga caa gct gct gag gtt cca ctt tcc tct gga gat gtt ctg tac cag     2832
 Gly Gln Ala Ala Glu Val Pro Leu Ser Ser Gly Asp Val Leu Tyr Gln
     930                 935                 940

 ggc ttc cca cct cga ctg cca cca cag tac cca gga gat tca aat att     2880
 Gly Phe Pro Pro Arg Leu Pro Pro Gln Tyr Pro Gly Asp Ser Asn Ile
 945                 950                 955                 960

 gct ccc tct tcc aac gtg gct tct gtt tgc atc cat tct aca gtc cta     2928
 Ala Pro Ser Ser Asn Val Ala Ser Val Cys Ile His Ser Thr Val Leu
                 965                 970                 975

 tcc cct ccc atg ccg aca gaa gta ctg gct aca cct ggg tac ttt ccc     2976
 Ser Pro Pro Met Pro Thr Glu Val Leu Ala Thr Pro Gly Tyr Phe Pro
             980                 985                 990

 aca gtg gtg cag cct tat gtg gaa tca aat ctt tta gtt cct atg ggt     3024
 Thr Val Val Gln Pro Tyr Val Glu Ser Asn Leu Leu Val Pro Met Gly
         995                1000                1005

 ggt gta gga gga cag gtt caa gtg tcc cag cca gga ggg agt tta gca     3072
 Gly Val Gly Gly Gln Val Gln Val Ser Gln Pro Gly Gly Ser Leu Ala
    1010                1015                1020

 caa gcc ccc act aca tcc tcc cag caa gca gtt ttg gag agt act cag     3120
 Gln Ala Pro Thr Thr Ser Ser Gln Gln Ala Val Leu Glu Ser Thr Gln
1025                1030                1035                1040

 gga gtc tct cag gtt gct cct gca gag cca gtt gca gta gca cag ccc     3168
 Gly Val Ser Gln Val Ala Pro Ala Glu Pro Val Ala Val Ala Gln Pro
                1045                1050                1055

 caa gct acc cag ccg acc act ttg gct tcc tct gta gac agt gca cat     3216
 Gln Ala Thr Gln Pro Thr Thr Leu Ala Ser Ser Val Asp Ser Ala His
            1060                1065                1070

 tca gat gtt gct tca ggt atg agt gat ggc aat gag aac gtc cca tct     3264
 Ser Asp Val Ala Ser Gly Met Ser Asp Gly Asn Glu Asn Val Pro Ser
        1075                1080                1085

 tcc agt gga agg cat gaa gga aga act aca aaa cgg cat tac cga aaa     3312
 Ser Ser Gly Arg His Glu Gly Arg Thr Thr Lys Arg His Tyr Arg Lys
    1090                1095                1100

 tct gta agg agt cgc tct cga cat gaa aaa act tca cgc cca aaa tta     3360
 Ser Val Arg Ser Arg Ser Arg His Glu Lys Thr Ser Arg Pro Lys Leu
1105                1110                1115                1120

 aga att ttg aat gtt tca aat aaa gga gac cga gta gta gaa tgt caa     3408
 Arg Ile Leu Asn Val Ser Asn Lys Gly Asp Arg Val Val Glu Cys Gln
                1125                1130                1135

 tta gag act cat aat agg aaa atg gtt aca ttc aaa ttt gac cta gat     3456
 Leu Glu Thr His Asn Arg Lys Met Val Thr Phe Lys Phe Asp Leu Asp
            1140                1145                1150

 ggt gac aac ccc gag gag ata gca aca att atg gtg aac aat gac ttt     3504
 Gly Asp Asn Pro Glu Glu Ile Ala Thr Ile Met Val Asn Asn Asp Phe
        1155                1160                1165

 att cta gca ata gag aga gag tcg ttt gtg gat caa gtg cga gaa att     3552
 Ile Leu Ala Ile Glu Arg Glu Ser Phe Val Asp Gln Val Arg Glu Ile
    1170                1175                1180

 att gaa aaa gct gat gaa atg ctc agt gag gat gtc agt gtg gaa cca     3600
 Ile Glu Lys Ala Asp Glu Met Leu Ser Glu Asp Val Ser Val Glu Pro
1185                1190                1195                1200

 gag ggt gat cag gga ttg gag agt cta caa gga aag gat gac tat ggc     3648
 Glu Gly Asp Gln Gly Leu Glu Ser Leu Gln Gly Lys Asp Asp Tyr Gly
                1205                1210                1215

 ttt tca ggt tct cag aaa ttg gaa gga gag ttc aaa caa cca att cct     3696
 Phe Ser Gly Ser Gln Lys Leu Glu Gly Glu Phe Lys Gln Pro Ile Pro
            1220                1225                1230

 gcg tct tcc atg cca cag caa ata ggc att cct acc agt tct tta act     3744
 Ala Ser Ser Met Pro Gln Gln Ile Gly Ile Pro Thr Ser Ser Leu Thr
        1235                1240                1245

 caa gtt gtt cat tct gcg gga agg cgg ttt ata gtg agt cct gtg cca     3792
 Gln Val Val His Ser Ala Gly Arg Arg Phe Ile Val Ser Pro Val Pro
    1250                1255                1260

 gaa agc cga tta cga gaa tca aaa gtt ttc ccc agt gaa ata aca gat     3840
 Glu Ser Arg Leu Arg Glu Ser Lys Val Phe Pro Ser Glu Ile Thr Asp
1265                1270                1275                1280

 aca gtt gct gcc tct aca gct cag agc cct gga atg aac ttg tct cac     3888
 Thr Val Ala Ala Ser Thr Ala Gln Ser Pro Gly Met Asn Leu Ser His
                1285                1290                1295

 tct gca tca tcc ctt agt cta caa cag gcc ttt tct gaa ctt aga cgt     3936
 Ser Ala Ser Ser Leu Ser Leu Gln Gln Ala Phe Ser Glu Leu Arg Arg
            1300                1305                1310

 gcc caa atg aca gaa gga ccc aac aca gca cct cca aac ttt agt cat     3984
 Ala Gln Met Thr Glu Gly Pro Asn Thr Ala Pro Pro Asn Phe Ser His
        1315                1320                1325

 aca gga cca aca ttt cca gta gta cct cct ttc tta agt agc att gct     4032
 Thr Gly Pro Thr Phe Pro Val Val Pro Pro Phe Leu Ser Ser Ile Ala
    1330                1335                1340

 gga gtc cca acc aca gca gca gcc aca gca cca gtc cct gca aca agc     4080
 Gly Val Pro Thr Thr Ala Ala Ala Thr Ala Pro Val Pro Ala Thr Ser
1345                1350                1355                1360

 agc cct cct aat gac att tcc aca tca gta att cag tct gag gtt aca     4128
 Ser Pro Pro Asn Asp Ile Ser Thr Ser Val Ile Gln Ser Glu Val Thr
                1365                1370                1375

 gtg ccc act gaa gag ggg att gct gga gtt gcc acc agc aca ggt gtg     4176
 Val Pro Thr Glu Glu Gly Ile Ala Gly Val Ala Thr Ser Thr Gly Val
            1380                1385                1390

 gta act tca ggt ggt ctc ccc ata cca cct gtg tct gaa tca cca gta     4224
 Val Thr Ser Gly Gly Leu Pro Ile Pro Pro Val Ser Glu Ser Pro Val
        1395                1400                1405

 ctt tcc agc gta gtt tca agt atc aca ata cct gca gtt gtc tca ata     4272
 Leu Ser Ser Val Val Ser Ser Ile Thr Ile Pro Ala Val Val Ser Ile
    1410                1415                1420

 tct act aca tcc ccg tca ctt caa gtc ccc aca tcc aca tct gag atc     4320
 Ser Thr Thr Ser Pro Ser Leu Gln Val Pro Thr Ser Thr Ser Glu Ile
1425                1430                1435                1440

 gtt gtt tct agt aca gca ctg tat cct tca gta aca gtt tca gca act     4368
 Val Val Ser Ser Thr Ala Leu Tyr Pro Ser Val Thr Val Ser Ala Thr
                1445                1450                1455

 tca gcc tct gca ggg ggc agt act gct acc cca ggt cct aag cct cca     4416
 Ser Ala Ser Ala Gly Gly Ser Thr Ala Thr Pro Gly Pro Lys Pro Pro
            1460                1465                1470

 gct gta gta tct cag cag gca gca ggc agc act act gtg gga gcc aca     4464
 Ala Val Val Ser Gln Gln Ala Ala Gly Ser Thr Thr Val Gly Ala Thr
        1475                1480                1485

 tta aca tca gtt tct acc acc act tca ttc cca agc aca gct tca cag     4512
 Leu Thr Ser Val Ser Thr Thr Thr Ser Phe Pro Ser Thr Ala Ser Gln
    1490                1495                1500

 ctg tcc att cag ctt agc agc agt act tct act cct act tta gct gaa     4560
 Leu Ser Ile Gln Leu Ser Ser Ser Thr Ser Thr Pro Thr Leu Ala Glu
1505                1510                1515                1520

 acc gtg gta gtt agc gca cac tca cta gat aag aca tct cat agc agt     4608
 Thr Val Val Val Ser Ala His Ser Leu Asp Lys Thr Ser His Ser Ser
                1525                1530                1535

 aca act gga ttg gct ttc tcc ctc tct gca cca tct tcc tct tcc tct     4656
 Thr Thr Gly Leu Ala Phe Ser Leu Ser Ala Pro Ser Ser Ser Ser Ser
            1540                1545                1550

 cct gga gca gga gtg tct agt tat att tct cag cct ggt ggg ctg cat     4704
 Pro Gly Ala Gly Val Ser Ser Tyr Ile Ser Gln Pro Gly Gly Leu His
        1555                1560                1565

 cct ttg gtc att cca tca gtg ata gct tct act cct att ctt ccc caa     4752
 Pro Leu Val Ile Pro Ser Val Ile Ala Ser Thr Pro Ile Leu Pro Gln
    1570                1575                1580

 gca gca gga cct act tct aca cct tta tta ccc caa gta cct agt atc     4800
 Ala Ala Gly Pro Thr Ser Thr Pro Leu Leu Pro Gln Val Pro Ser Ile
1585                1590                1595                1600

 cca ccc ttg gta cag cct gtt gcc aat gtg cct gct gta cag cag aca     4848
 Pro Pro Leu Val Gln Pro Val Ala Asn Val Pro Ala Val Gln Gln Thr
                1605                1610                1615

 cta att cat agt cag cct caa cca gct ttg ctt ccc aac cag ccc cat     4896
 Leu Ile His Ser Gln Pro Gln Pro Ala Leu Leu Pro Asn Gln Pro His
            1620                1625                1630

 act cat tgt cct gaa gta gat tct gat aca caa ccc aaa gct cct gga     4944
 Thr His Cys Pro Glu Val Asp Ser Asp Thr Gln Pro Lys Ala Pro Gly
        1635                1640                1645

 att gat gac ata aag act cta gaa gaa aag ctg cgg tct ctg ttc agt     4992
 Ile Asp Asp Ile Lys Thr Leu Glu Glu Lys Leu Arg Ser Leu Phe Ser
    1650                1655                1660

 gaa cac agc tca tct gga gct cag cat gcc tct gtc tca ctg gag acc     5040
 Glu His Ser Ser Ser Gly Ala Gln His Ala Ser Val Ser Leu Glu Thr
1665                1670                1675                1680

 tca cta gtc ata gag agc act gtc aca cca ggc atc cca act act gct     5088
 Ser Leu Val Ile Glu Ser Thr Val Thr Pro Gly Ile Pro Thr Thr Ala
                1685                1690                1695

 gtt gca cca agc aaa ctc ctg act tct acc aca agt act tgc tta cca     5136
 Val Ala Pro Ser Lys Leu Leu Thr Ser Thr Thr Ser Thr Cys Leu Pro
            1700                1705                1710

 cca acc aat tta cca cta gga aca gtt gct ttg cca gtt aca cca gtg     5184
 Pro Thr Asn Leu Pro Leu Gly Thr Val Ala Leu Pro Val Thr Pro Val
        1715                1720                1725

 gtc ata cct ggg caa gtt tct acc cca gtc agc act act aca tca gga     5232
 Val Ile Pro Gly Gln Val Ser Thr Pro Val Ser Thr Thr Thr Ser Gly
    1730                1735                1740

 gtg aaa cct gga act gct ccc tcc aag cca cct cta act aag gct ccg     5280
 Val Lys Pro Gly Thr Ala Pro Ser Lys Pro Pro Leu Thr Lys Ala Pro
1745                1750                1755                1760

 gtg ctg cca gtg ggt act gaa ctt cca gca ggt act cta ccc agc gag     5328
 Val Leu Pro Val Gly Thr Glu Leu Pro Ala Gly Thr Leu Pro Ser Glu
                1765                1770                1775

 cag ctg cca cct ttt cca gga cct tct cta acc cag tcc cag caa cct     5376
 Gln Leu Pro Pro Phe Pro Gly Pro Ser Leu Thr Gln Ser Gln Gln Pro
            1780                1785                1790

 cta gag gat ctt gat gct caa ttg aga aga aca ctt agt cca gag att     5424
 Leu Glu Asp Leu Asp Ala Gln Leu Arg Arg Thr Leu Ser Pro Glu Ile
        1795                1800                1805

 atc aca gtg act tct gcg gtt ggt cct gtg tcc atg gcg gct cca aca     5472
 Ile Thr Val Thr Ser Ala Val Gly Pro Val Ser Met Ala Ala Pro Thr
    1810                1815                1820

 gca atc aca gaa gca gga aca cag cct cag aag ggt gtt tct caa gtc     5520
 Ala Ile Thr Glu Ala Gly Thr Gln Pro Gln Lys Gly Val Ser Gln Val
1825                1830                1835                1840

 aaa gaa ggc cct gtc cta gca act agt tca gga gct ggt gtt ttt aag     5568
 Lys Glu Gly Pro Val Leu Ala Thr Ser Ser Gly Ala Gly Val Phe Lys
                1845                1850                1855

 atg gga cga ttt cag gtt tct gtt gca gca gac ggt gcc cag aaa gag     5616
 Met Gly Arg Phe Gln Val Ser Val Ala Ala Asp Gly Ala Gln Lys Glu
            1860                1865                1870

 ggt aaa aat aag tca gaa gat gca aag tct gtt cat ttt gaa tcc agc     5664
 Gly Lys Asn Lys Ser Glu Asp Ala Lys Ser Val His Phe Glu Ser Ser
        1875                1880                1885

 acc tca gag tcc tca gtg cta tca agt agt agt cca gag agt acc ttg     5712
 Thr Ser Glu Ser Ser Val Leu Ser Ser Ser Ser Pro Glu Ser Thr Leu
    1890                1895                1900

 gtg aaa cca gag ccg aat ggc ata acc atc cct ggt atc tct tca gat     5760
 Val Lys Pro Glu Pro Asn Gly Ile Thr Ile Pro Gly Ile Ser Ser Asp
1905                1910                1915                1920

 gtg cca gag agt gcc cac aaa act act gcc tca gag gca aag tca gac     5808
 Val Pro Glu Ser Ala His Lys Thr Thr Ala Ser Glu Ala Lys Ser Asp
                1925                1930                1935

 act ggg cag cct acc aag gtt gga cgt ttt cag gtg aca act aca gca     5856
 Thr Gly Gln Pro Thr Lys Val Gly Arg Phe Gln Val Thr Thr Thr Ala
            1940                1945                1950

 aac aaa gtg ggt cgt ttc tct gta tca aaa act gag gac aag atc act     5904
 Asn Lys Val Gly Arg Phe Ser Val Ser Lys Thr Glu Asp Lys Ile Thr
        1955                1960                1965

 gac aca aag aaa gaa gga cca gtg gca tct cct cct ttt atg gat ttg     5952
 Asp Thr Lys Lys Glu Gly Pro Val Ala Ser Pro Pro Phe Met Asp Leu
    1970                1975                1980

 gaa caa gct gtt ctt cct gct gtg ata cca aag aaa gag aag cct gaa     6000
 Glu Gln Ala Val Leu Pro Ala Val Ile Pro Lys Lys Glu Lys Pro Glu
1985                1990                1995                2000

 ctg tca gag cct tca cat cta aat ggg ccg tct tct gac ccg gag gcc     6048
 Leu Ser Glu Pro Ser His Leu Asn Gly Pro Ser Ser Asp Pro Glu Ala
                2005                2010                2015

 gct ttt tta agt agg gat gtg gat gat ggt tcc ggt agt cca cac tcg     6096
 Ala Phe Leu Ser Arg Asp Val Asp Asp Gly Ser Gly Ser Pro His Ser
            2020                2025                2030

 ccc cat cag ctg agc tca aag agc ctt cct agc cag aat cta agt caa     6144
 Pro His Gln Leu Ser Ser Lys Ser Leu Pro Ser Gln Asn Leu Ser Gln
        2035                2040                2045

 agc ctt agt aat tca ttt aac tcc tct tac atg agt agc gac aat gag     6192
 Ser Leu Ser Asn Ser Phe Asn Ser Ser Tyr Met Ser Ser Asp Asn Glu
    2050                2055                2060

 tca gat atc gaa gat gaa gac tta aag tta gag ctg cga cga cta cga     6240
 Ser Asp Ile Glu Asp Glu Asp Leu Lys Leu Glu Leu Arg Arg Leu Arg
2065                2070                2075                2080

 gat aaa cat ctc aaa gag att cag gac ctg cag agt cgc cag aag cat     6288
 Asp Lys His Leu Lys Glu Ile Gln Asp Leu Gln Ser Arg Gln Lys His
                2085                2090                2095

 gaa att gaa tct ttg tat acc aaa ctg ggc aag gtg ccc cct gct gtt     6336
 Glu Ile Glu Ser Leu Tyr Thr Lys Leu Gly Lys Val Pro Pro Ala Val
            2100                2105                2110

 att att ccc cca gct gct ccc ctt tca ggg aga aga cga cga ccc act     6384
 Ile Ile Pro Pro Ala Ala Pro Leu Ser Gly Arg Arg Arg Arg Pro Thr
        2115                2120                2125

 aaa agc aaa ggc agc aaa tct agt cga agc agt tcc ttg ggg aat aaa     6432
 Lys Ser Lys Gly Ser Lys Ser Ser Arg Ser Ser Ser Leu Gly Asn Lys
    2130                2135                2140

 agc ccc cag ctt tca ggt aac ctg tct ggt cag agt gca gct tca gtc     6480
 Ser Pro Gln Leu Ser Gly Asn Leu Ser Gly Gln Ser Ala Ala Ser Val
2145                2150                2155                2160

 ttg cac ccc cag cag acc ctc cac cct cct ggc aac atc cca gag tcc     6528
 Leu His Pro Gln Gln Thr Leu His Pro Pro Gly Asn Ile Pro Glu Ser
                2165                2170                2175

 ggg cag aat cag ctg tta cag ccc ctt aag cca tct ccc tcc agt gac     6576
 Gly Gln Asn Gln Leu Leu Gln Pro Leu Lys Pro Ser Pro Ser Ser Asp
            2180                2185                2190

 aac ctc tat tca gcc ttc acc agt gat ggt gcc att tca gta cca agc     6624
 Asn Leu Tyr Ser Ala Phe Thr Ser Asp Gly Ala Ile Ser Val Pro Ser
        2195                2200                2205

 ctt tct gct cca ggt caa gga acc agc agc aca aac act gtt ggg gca     6672
 Leu Ser Ala Pro Gly Gln Gly Thr Ser Ser Thr Asn Thr Val Gly Ala
    2210                2215                2220

 aca gtg aac agc caa gcc gcc caa gct cag cct cct gcc atg acg tcc     6720
 Thr Val Asn Ser Gln Ala Ala Gln Ala Gln Pro Pro Ala Met Thr Ser
2225                2230                2235                2240

 agc agg aag ggc aca ttc aca gat gac ttg cac aag ttg gta gac aat     6768
 Ser Arg Lys Gly Thr Phe Thr Asp Asp Leu His Lys Leu Val Asp Asn
                2245                2250                2255

 tgg gcc cga gat gcc atg aat ctc tca ggc agg aga gga agc aaa ggg     6816
 Trp Ala Arg Asp Ala Met Asn Leu Ser Gly Arg Arg Gly Ser Lys Gly
            2260                2265                2270

 cac atg aat tat gag ggc cct gga atg gca agg aag ttc tct gca cct     6864
 His Met Asn Tyr Glu Gly Pro Gly Met Ala Arg Lys Phe Ser Ala Pro
        2275                2280                2285

 ggg caa ctg tgc atc tcc atg acc tcg aac ctg ggt ggc tct gcc ccc     6912
 Gly Gln Leu Cys Ile Ser Met Thr Ser Asn Leu Gly Gly Ser Ala Pro
    2290                2295                2300

 atc tct gca gca tca gct acc tct cta ggt cac ttc acc aag tct atg     6960
 Ile Ser Ala Ala Ser Ala Thr Ser Leu Gly His Phe Thr Lys Ser Met
2305                2310                2315                2320

 tgc ccc cca cag cag tat ggc ttt cca gct acc cca ttt ggc gct caa     7008
 Cys Pro Pro Gln Gln Tyr Gly Phe Pro Ala Thr Pro Phe Gly Ala Gln
                2325                2330                2335

 tgg agt ggg acg ggt ggc cca gca cca cag cca ctt ggc cag ttc aca     7056
 Trp Ser Gly Thr Gly Gly Pro Ala Pro Gln Pro Leu Gly Gln Phe Thr
            2340                2345                2350

 act gtg gac aac tcg ctc ctt gcc gaa ttc caa cat cca gca atc tgc     7104
 Thr Val Asp Asn Ser Leu Leu Ala Glu Phe Gln His Pro Ala Ile Cys
        2355                2360                2365

 cga cac tcc act cga aca aca cac caa ggg cat cca aac aag cgg aac     7152
 Arg His Ser Thr Arg Thr Thr His Gln Gly His Pro Asn Lys Arg Asn
    2370                2375                2380

 cac att gaa aca tag acaaacattt acctgcaaca tagaccacat ggaaggcaaa     7207
 His Ile Glu Thr 
2385

 agcaaatatg aactacctat acaggacaat aacatcacaa acatcgagca acaatacgcc   7267

 aactattaat taaaacactc acccgccgat tatcacagac ccaatctaat gcca         7321




      <210> 673
      <211> 6294
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (195)..(6140)

      <400> 673
 ccatctagaa taatctgttg ttggctgagt agagcaattt ctgtctgaga gttgggaagc     60

 atggctagtg ttaacaagaa actgtgtttc agtctgactt tgatgtctgc cttccttatg    120

 ctgtgggctg atgtacatca gagacatttt ttccttcatt ttcctccaat aagaaatctg    180

 ttttgccttt tctg  atg gat att aaa aag aaa gat ttt tgc tca gta ttt     230
                  Met Asp Ile Lys Lys Lys Asp Phe Cys Ser Val Phe
                    1               5                  10

 gtc atc ata aat tct cat tgc tgc tgc tgc cct caa aag gat tgt ata      278
 Val Ile Ile Asn Ser His Cys Cys Cys Cys Pro Gln Lys Asp Cys Ile
          15                  20                  25

 aat gag ggg gtg aag cca gcc agt ttt gac aaa gta gca att cct gaa      326
 Asn Glu Gly Val Lys Pro Ala Ser Phe Asp Lys Val Ala Ile Pro Glu
      30                  35                  40

 gtg aag gaa att att gaa gga tgc ata cga caa aac aaa gat gaa aga      374
 Val Lys Glu Ile Ile Glu Gly Cys Ile Arg Gln Asn Lys Asp Glu Arg
  45                  50                  55                  60

 tat tcc atc aaa gac ctt ttg aac cat gcc ttc ttc caa gag gaa aca      422
 Tyr Ser Ile Lys Asp Leu Leu Asn His Ala Phe Phe Gln Glu Glu Thr
                  65                  70                  75

 gga gta cgg gta gaa tta gca gaa gaa gat gat gga gaa aaa ata gcc      470
 Gly Val Arg Val Glu Leu Ala Glu Glu Asp Asp Gly Glu Lys Ile Ala
              80                  85                  90

 ata aaa tta tgg cta cgt att gaa gat att aag aaa tta aag gga aaa      518
 Ile Lys Leu Trp Leu Arg Ile Glu Asp Ile Lys Lys Leu Lys Gly Lys
          95                 100                 105

 tac aaa gat aat gaa gct att gag ttt tct ttt gat tta gag aga gat      566
 Tyr Lys Asp Asn Glu Ala Ile Glu Phe Ser Phe Asp Leu Glu Arg Asp
     110                 115                 120

 gtc cca gaa gat gtt gca caa gaa atg gta gag tct ggg tat gtc tgt      614
 Val Pro Glu Asp Val Ala Gln Glu Met Val Glu Ser Gly Tyr Val Cys
 125                 130                 135                 140

 gaa ggt gat cac aag acc atg gct aaa gct atc aaa gac aga gta tca      662
 Glu Gly Asp His Lys Thr Met Ala Lys Ala Ile Lys Asp Arg Val Ser
                 145                 150                 155

 tta att aag agg aaa cga gag cag cgg cag ttg gta cgg gag gag caa      710
 Leu Ile Lys Arg Lys Arg Glu Gln Arg Gln Leu Val Arg Glu Glu Gln
             160                 165                 170

 gaa aaa aaa aag cag gaa gag agc agt ctc aaa cag cag gta gaa caa      758
 Glu Lys Lys Lys Gln Glu Glu Ser Ser Leu Lys Gln Gln Val Glu Gln
         175                 180                 185

 tcc agt gct tcc cag aca gga atc aag cag ctc cct tct gct agc acc      806
 Ser Ser Ala Ser Gln Thr Gly Ile Lys Gln Leu Pro Ser Ala Ser Thr
     190                 195                 200

 ggc ata cct act gct tct acc act tca gct tca gtt tct aca caa gta      854
 Gly Ile Pro Thr Ala Ser Thr Thr Ser Ala Ser Val Ser Thr Gln Val
 205                 210                 215                 220

 gaa cct gaa gaa cct gag gca gat caa cat caa caa cta cag tac cag      902
 Glu Pro Glu Glu Pro Glu Ala Asp Gln His Gln Gln Leu Gln Tyr Gln
                 225                 230                 235

 caa ccc agt ata tct gtg tta tct gat ggg acg gtt gac agt ggt cag      950
 Gln Pro Ser Ile Ser Val Leu Ser Asp Gly Thr Val Asp Ser Gly Gln
             240                 245                 250

 gga tcc tct gtc ttc aca gaa tct cga gtg agc agc caa cag aca gtt      998
 Gly Ser Ser Val Phe Thr Glu Ser Arg Val Ser Ser Gln Gln Thr Val
         255                 260                 265

 tca tat ggt tcc caa cat gaa cag gca cat tct aca ggc aca gtc cca     1046
 Ser Tyr Gly Ser Gln His Glu Gln Ala His Ser Thr Gly Thr Val Pro
     270                 275                 280

 ggg cat ata cct tct act gtc caa gca cag tct cag ccc cat ggg gta     1094
 Gly His Ile Pro Ser Thr Val Gln Ala Gln Ser Gln Pro His Gly Val
 285                 290                 295                 300

 tat cca ccc tca agt gtg gca cag ggg cag agc cag ggt cag cca tcc     1142
 Tyr Pro Pro Ser Ser Val Ala Gln Gly Gln Ser Gln Gly Gln Pro Ser
                 305                 310                 315

 tca agt agc tta aca ggg gtt tca tct tcc caa ccc ata caa cat cct     1190
 Ser Ser Ser Leu Thr Gly Val Ser Ser Ser Gln Pro Ile Gln His Pro
             320                 325                 330

 cag cag cag cag gga ata cag cag aca gcc cct cct caa cag aca gtg     1238
 Gln Gln Gln Gln Gly Ile Gln Gln Thr Ala Pro Pro Gln Gln Thr Val
         335                 340                 345

 cag tat tca ctt tca cag aca tca acc tcc agt gag gcc act act gca     1286
 Gln Tyr Ser Leu Ser Gln Thr Ser Thr Ser Ser Glu Ala Thr Thr Ala
     350                 355                 360

 cag cca gtg agt caa cct caa gct cca caa gtc ttg cct caa gta tca     1334
 Gln Pro Val Ser Gln Pro Gln Ala Pro Gln Val Leu Pro Gln Val Ser
 365                 370                 375                 380

 gct gga aaa cag ctt cca gtt tcc cag cca gta cca act atc caa ggc     1382
 Ala Gly Lys Gln Leu Pro Val Ser Gln Pro Val Pro Thr Ile Gln Gly
                 385                 390                 395

 gaa cct cag atc cca gtt gcg aca caa ccc tcg gtt gtt cca gtc cac     1430
 Glu Pro Gln Ile Pro Val Ala Thr Gln Pro Ser Val Val Pro Val His
             400                 405                 410

 tct ggt gct cat ttc ctt cca gtg gga cag ccg ctc cct act ccc ttg     1478
 Ser Gly Ala His Phe Leu Pro Val Gly Gln Pro Leu Pro Thr Pro Leu
         415                 420                 425

 ctc cct cag tac cct gtc tct cag att ccc ata tca act cct cat gtg     1526
 Leu Pro Gln Tyr Pro Val Ser Gln Ile Pro Ile Ser Thr Pro His Val
     430                 435                 440

 tct acg gct cag aca ggt ttc tca tcc ctt ccc atc aca atg gca gct     1574
 Ser Thr Ala Gln Thr Gly Phe Ser Ser Leu Pro Ile Thr Met Ala Ala
 445                 450                 455                 460

 ggc att act cag cct ctg ctc acg ttg gct tca tct gct aca aca gct     1622
 Gly Ile Thr Gln Pro Leu Leu Thr Leu Ala Ser Ser Ala Thr Thr Ala
                 465                 470                 475

 gcg atc ccg ggg gta tca act gtg gtt cct agt cag ctt cca acc ctt     1670
 Ala Ile Pro Gly Val Ser Thr Val Val Pro Ser Gln Leu Pro Thr Leu
             480                 485                 490

 ctg cag cct gtg act cag ctg cca agt cag gtt cac cca cag ctc cta     1718
 Leu Gln Pro Val Thr Gln Leu Pro Ser Gln Val His Pro Gln Leu Leu
         495                 500                 505

 caa cca gca gtt cag tcc atg gga ata cca gct aac ctt gga caa gct     1766
 Gln Pro Ala Val Gln Ser Met Gly Ile Pro Ala Asn Leu Gly Gln Ala
     510                 515                 520

 gct gag gtt cca ctt tcc tct gga gat gtt ctg tac cag ggc ttc cca     1814
 Ala Glu Val Pro Leu Ser Ser Gly Asp Val Leu Tyr Gln Gly Phe Pro
 525                 530                 535                 540

 cct cga ctg cca cca cag tac cca gga gat tca aat att gct ccc tct     1862
 Pro Arg Leu Pro Pro Gln Tyr Pro Gly Asp Ser Asn Ile Ala Pro Ser
                 545                 550                 555

 tcc aac gtg gct tct gtt tgc atc cat tct aca gtc cta tcc cct ccc     1910
 Ser Asn Val Ala Ser Val Cys Ile His Ser Thr Val Leu Ser Pro Pro
             560                 565                 570

 atg ccg aca gaa gta ctg gct aca cct ggg tac ttt ccc aca gtg gtg     1958
 Met Pro Thr Glu Val Leu Ala Thr Pro Gly Tyr Phe Pro Thr Val Val
         575                 580                 585

 cag cct tat gtg gaa tca aat ctt tta gtt cct atg ggt ggt gta gga     2006
 Gln Pro Tyr Val Glu Ser Asn Leu Leu Val Pro Met Gly Gly Val Gly
     590                 595                 600

 gga cag gtt caa gtg tcc cag cca gga ggg agt tta gca caa gcc ccc     2054
 Gly Gln Val Gln Val Ser Gln Pro Gly Gly Ser Leu Ala Gln Ala Pro
 605                 610                 615                 620

 act aca tcc tcc cag caa gca gtt ttg gag agt act cag gga gtc tct     2102
 Thr Thr Ser Ser Gln Gln Ala Val Leu Glu Ser Thr Gln Gly Val Ser
                 625                 630                 635

 cag gtt gct cct gca gag cca gtt gca gta gca cag ccc caa gct acc     2150
 Gln Val Ala Pro Ala Glu Pro Val Ala Val Ala Gln Pro Gln Ala Thr
             640                 645                 650

 cag ccg acc act ttg gct tcc tct gta gac agt gca cat tca gat gtt     2198
 Gln Pro Thr Thr Leu Ala Ser Ser Val Asp Ser Ala His Ser Asp Val
         655                 660                 665

 gct tca ggt atg agt gat ggc aat gag aac gtc cca tct tcc agt gga     2246
 Ala Ser Gly Met Ser Asp Gly Asn Glu Asn Val Pro Ser Ser Ser Gly
     670                 675                 680

 agg cat gaa gga aga act aca aaa cgg cat tac cga aaa tct gta agg     2294
 Arg His Glu Gly Arg Thr Thr Lys Arg His Tyr Arg Lys Ser Val Arg
 685                 690                 695                 700

 agt cgc tct cga cat gaa aaa act tca cgc cca aaa tta aga att ttg     2342
 Ser Arg Ser Arg His Glu Lys Thr Ser Arg Pro Lys Leu Arg Ile Leu
                 705                 710                 715

 aat gtt tca aat aaa gga gac cga gta gta gaa tgt caa tta gag act     2390
 Asn Val Ser Asn Lys Gly Asp Arg Val Val Glu Cys Gln Leu Glu Thr
             720                 725                 730

 cat aat agg aaa atg gtt aca ttc aaa ttt gac cta gat ggt gac aac     2438
 His Asn Arg Lys Met Val Thr Phe Lys Phe Asp Leu Asp Gly Asp Asn
         735                 740                 745

 ccc gag gag ata gca aca att atg gtg aac aat gac ttt att cta gca     2486
 Pro Glu Glu Ile Ala Thr Ile Met Val Asn Asn Asp Phe Ile Leu Ala
     750                 755                 760

 ata gag aga gag tcg ttt gtg gat caa gtg cga gaa att att gaa aaa     2534
 Ile Glu Arg Glu Ser Phe Val Asp Gln Val Arg Glu Ile Ile Glu Lys
 765                 770                 775                 780

 gct gat gaa atg ctc agt gag gat gtc agt gtg gaa cca gag ggt gat     2582
 Ala Asp Glu Met Leu Ser Glu Asp Val Ser Val Glu Pro Glu Gly Asp
                 785                 790                 795

 cag gga ttg gag agt cta caa gga aag gat gac tat ggc ttt tca ggt     2630
 Gln Gly Leu Glu Ser Leu Gln Gly Lys Asp Asp Tyr Gly Phe Ser Gly
             800                 805                 810

 tct cag aaa ttg gaa gga gag ttc aaa caa cca att cct gcg tct tcc     2678
 Ser Gln Lys Leu Glu Gly Glu Phe Lys Gln Pro Ile Pro Ala Ser Ser
         815                 820                 825

 atg cca cag caa ata ggc att cct acc agt tct tta act caa gtt gtt     2726
 Met Pro Gln Gln Ile Gly Ile Pro Thr Ser Ser Leu Thr Gln Val Val
     830                 835                 840

 cat tct gcg gga agg cgg ttt ata gtg agt cct gtg cca gaa agc cga     2774
 His Ser Ala Gly Arg Arg Phe Ile Val Ser Pro Val Pro Glu Ser Arg
 845                 850                 855                 860

 tta cga gaa tca aaa gtt ttc ccc agt gaa ata aca gat aca gtt gct     2822
 Leu Arg Glu Ser Lys Val Phe Pro Ser Glu Ile Thr Asp Thr Val Ala
                 865                 870                 875

 gcc tct aca gct cag agc cct gga atg aac ttg tct cac tct gca tca     2870
 Ala Ser Thr Ala Gln Ser Pro Gly Met Asn Leu Ser His Ser Ala Ser
             880                 885                 890

 tcc ctt agt cta caa cag gcc ttt tct gaa ctt aga cgt gcc caa atg     2918
 Ser Leu Ser Leu Gln Gln Ala Phe Ser Glu Leu Arg Arg Ala Gln Met
         895                 900                 905

 aca gaa gga ccc aac aca gca cct cca aac ttt agt cat aca gga cca     2966
 Thr Glu Gly Pro Asn Thr Ala Pro Pro Asn Phe Ser His Thr Gly Pro
     910                 915                 920

 aca ttt cca gta gta cct cct ttc tta agt agc att gct gga gtc cca     3014
 Thr Phe Pro Val Val Pro Pro Phe Leu Ser Ser Ile Ala Gly Val Pro
 925                 930                 935                 940

 acc aca gca gca gcc aca gca cca gtc cct gca aca agc agc cct cct     3062
 Thr Thr Ala Ala Ala Thr Ala Pro Val Pro Ala Thr Ser Ser Pro Pro
                 945                 950                 955

 aat gac att tcc aca tca gta att cag tct gag gtt aca gtg ccc act     3110
 Asn Asp Ile Ser Thr Ser Val Ile Gln Ser Glu Val Thr Val Pro Thr
             960                 965                 970

 gaa gag ggg att gct gga gtt gcc acc agc aca ggt gtg gta act tca     3158
 Glu Glu Gly Ile Ala Gly Val Ala Thr Ser Thr Gly Val Val Thr Ser
         975                 980                 985

 ggt ggt ctc ccc ata cca cct gtg tct gaa tca cca gta ctt tcc agc     3206
 Gly Gly Leu Pro Ile Pro Pro Val Ser Glu Ser Pro Val Leu Ser Ser
     990                 995                1000

 gta gtt tca agt atc aca ata cct gca gtt gtc tca ata tct act aca     3254
 Val Val Ser Ser Ile Thr Ile Pro Ala Val Val Ser Ile Ser Thr Thr
1005                1010                1015                1020

 tcc ccg tca ctt caa gtc ccc aca tcc aca tct gag atc gtt gtt tct     3302
 Ser Pro Ser Leu Gln Val Pro Thr Ser Thr Ser Glu Ile Val Val Ser
                1025                1030                1035

 agt aca gca ctg tat cct tca gta aca gtt tca gca act tca gcc tct     3350
 Ser Thr Ala Leu Tyr Pro Ser Val Thr Val Ser Ala Thr Ser Ala Ser
            1040                1045                1050

 gca ggg ggc agt act gct acc cca ggt cct aag cct cca gct gta gta     3398
 Ala Gly Gly Ser Thr Ala Thr Pro Gly Pro Lys Pro Pro Ala Val Val
        1055                1060                1065

 tct cag cag gca gca ggc agc act act gtg gga gcc aca tta aca tca     3446
 Ser Gln Gln Ala Ala Gly Ser Thr Thr Val Gly Ala Thr Leu Thr Ser
    1070                1075                1080

 gtt tct acc acc act tca ttc cca agc aca gct tca cag ctg tcc att     3494
 Val Ser Thr Thr Thr Ser Phe Pro Ser Thr Ala Ser Gln Leu Ser Ile
1085                1090                1095                1100

 cag ctt agc agc agt act tct act cct act tta gct gaa acc gtg gta     3542
 Gln Leu Ser Ser Ser Thr Ser Thr Pro Thr Leu Ala Glu Thr Val Val
                1105                1110                1115

 gtt agc gca cac tca cta gat aag aca tct cat agc agt aca act gga     3590
 Val Ser Ala His Ser Leu Asp Lys Thr Ser His Ser Ser Thr Thr Gly
            1120                1125                1130

 ttg gct ttc tcc ctc tct gca cca tct tcc tct tcc tct cct gga gca     3638
 Leu Ala Phe Ser Leu Ser Ala Pro Ser Ser Ser Ser Ser Pro Gly Ala
        1135                1140                1145

 gga gtg tct agt tat att tct cag cct ggt ggg ctg cat cct ttg gtc     3686
 Gly Val Ser Ser Tyr Ile Ser Gln Pro Gly Gly Leu His Pro Leu Val
    1150                1155                1160

 att cca tca gtg ata gct tct act cct att ctt ccc caa gca gca gga     3734
 Ile Pro Ser Val Ile Ala Ser Thr Pro Ile Leu Pro Gln Ala Ala Gly
1165                1170                1175                1180

 cct act tct aca cct tta tta ccc caa gta cct agt atc cca ccc ttg     3782
 Pro Thr Ser Thr Pro Leu Leu Pro Gln Val Pro Ser Ile Pro Pro Leu
                1185                1190                1195

 gta cag cct gtt gcc aat gtg cct gct gta cag cag aca cta att cat     3830
 Val Gln Pro Val Ala Asn Val Pro Ala Val Gln Gln Thr Leu Ile His
            1200                1205                1210

 agt cag cct caa cca gct ttg ctt ccc aac cag ccc cat act cat tgt     3878
 Ser Gln Pro Gln Pro Ala Leu Leu Pro Asn Gln Pro His Thr His Cys
        1215                1220                1225

 cct gaa gta gat tct gat aca caa ccc aaa gct cct gga att gat gac     3926
 Pro Glu Val Asp Ser Asp Thr Gln Pro Lys Ala Pro Gly Ile Asp Asp
    1230                1235                1240

 ata aag act cta gaa gaa aag ctg cgg tct ctg ttc agt gaa cac agc     3974
 Ile Lys Thr Leu Glu Glu Lys Leu Arg Ser Leu Phe Ser Glu His Ser
1245                1250                1255                1260

 tca tct gga gct cag cat gcc tct gtc tca ctg gag acc tca cta gtc     4022
 Ser Ser Gly Ala Gln His Ala Ser Val Ser Leu Glu Thr Ser Leu Val
                1265                1270                1275

 ata gag agc act gtc aca cca ggc atc cca act act gct gtt gca cca     4070
 Ile Glu Ser Thr Val Thr Pro Gly Ile Pro Thr Thr Ala Val Ala Pro
            1280                1285                1290

 agc aaa ctc ctg act tct acc aca agt act tgc tta cca cca acc aat     4118
 Ser Lys Leu Leu Thr Ser Thr Thr Ser Thr Cys Leu Pro Pro Thr Asn
        1295                1300                1305

 tta cca cta gga aca gtt gct ttg cca gtt aca cca gtg gtc ata cct     4166
 Leu Pro Leu Gly Thr Val Ala Leu Pro Val Thr Pro Val Val Ile Pro
    1310                1315                1320

 ggg caa gtt tct acc cca gtc agc act act aca tca gga gtg aaa cct     4214
 Gly Gln Val Ser Thr Pro Val Ser Thr Thr Thr Ser Gly Val Lys Pro
1325                1330                1335                1340

 gga act gct ccc tcc aag cca cct cta act aag gct ccg gtg ctg cca     4262
 Gly Thr Ala Pro Ser Lys Pro Pro Leu Thr Lys Ala Pro Val Leu Pro
                1345                1350                1355

 gtg ggt act gaa ctt cca gca ggt act cta ccc agc gag cag ctg cca     4310
 Val Gly Thr Glu Leu Pro Ala Gly Thr Leu Pro Ser Glu Gln Leu Pro
            1360                1365                1370

 cct ttt cca gga cct tct cta acc cag tcc cag caa cct cta gag gat     4358
 Pro Phe Pro Gly Pro Ser Leu Thr Gln Ser Gln Gln Pro Leu Glu Asp
        1375                1380                1385

 ctt gat gct caa ttg aga aga aca ctt agt cca gag att atc aca gtg     4406
 Leu Asp Ala Gln Leu Arg Arg Thr Leu Ser Pro Glu Ile Ile Thr Val
    1390                1395                1400

 act tct gcg gtt ggt cct gtg tcc atg gcg gct cca aca gca atc aca     4454
 Thr Ser Ala Val Gly Pro Val Ser Met Ala Ala Pro Thr Ala Ile Thr
1405                1410                1415                1420

 gaa gca gga aca cag cct cag aag ggt gtt tct caa gtc aaa gaa ggc     4502
 Glu Ala Gly Thr Gln Pro Gln Lys Gly Val Ser Gln Val Lys Glu Gly
                1425                1430                1435

 cct gtc cta gca act agt tca gga gct ggt gtt ttt aag atg gga cga     4550
 Pro Val Leu Ala Thr Ser Ser Gly Ala Gly Val Phe Lys Met Gly Arg
            1440                1445                1450

 ttt cag gtt tct gtt gca gca gac ggt gcc cag aaa gag ggt aaa aat     4598
 Phe Gln Val Ser Val Ala Ala Asp Gly Ala Gln Lys Glu Gly Lys Asn
        1455                1460                1465

 aag tca gaa gat gca aag tct gtt cat ttt gaa tcc agc acc tca gag     4646
 Lys Ser Glu Asp Ala Lys Ser Val His Phe Glu Ser Ser Thr Ser Glu
    1470                1475                1480

 tcc tca gtg cta tca agt agt agt cca gag agt acc ttg gtg aaa cca     4694
 Ser Ser Val Leu Ser Ser Ser Ser Pro Glu Ser Thr Leu Val Lys Pro
1485                1490                1495                1500

 gag ccg aat ggc ata acc atc cct ggt atc tct tca gat gtg cca gag     4742
 Glu Pro Asn Gly Ile Thr Ile Pro Gly Ile Ser Ser Asp Val Pro Glu
                1505                1510                1515

 agt gcc cac aaa act act gcc tca gag gca aag tca gac act ggg cag     4790
 Ser Ala His Lys Thr Thr Ala Ser Glu Ala Lys Ser Asp Thr Gly Gln
            1520                1525                1530

 cct acc aag gtt gga cgt ttt cag gtg aca act aca gca aac aaa gtg     4838
 Pro Thr Lys Val Gly Arg Phe Gln Val Thr Thr Thr Ala Asn Lys Val
        1535                1540                1545

 ggt cgt ttc tct gta tca aaa act gag gac aag atc act gac aca aag     4886
 Gly Arg Phe Ser Val Ser Lys Thr Glu Asp Lys Ile Thr Asp Thr Lys
    1550                1555                1560

 aaa gaa gga cca gtg gca tct cct cct ttt atg gat ttg gaa caa gct     4934
 Lys Glu Gly Pro Val Ala Ser Pro Pro Phe Met Asp Leu Glu Gln Ala
1565                1570                1575                1580

 gtt ctt cct gct gtg ata cca aag aaa gag aag cct gaa ctg tca gag     4982
 Val Leu Pro Ala Val Ile Pro Lys Lys Glu Lys Pro Glu Leu Ser Glu
                1585                1590                1595

 cct tca cat cta aat ggg ccg tct tct gac ccg gag gcc gct ttt tta     5030
 Pro Ser His Leu Asn Gly Pro Ser Ser Asp Pro Glu Ala Ala Phe Leu
            1600                1605                1610

 agt agg gat gtg gat gat ggt tcc ggt agt cca cac tcg ccc cat cag     5078
 Ser Arg Asp Val Asp Asp Gly Ser Gly Ser Pro His Ser Pro His Gln
        1615                1620                1625

 ctg agc tca aag agc ctt cct agc cag aat cta agt caa agc ctt agt     5126
 Leu Ser Ser Lys Ser Leu Pro Ser Gln Asn Leu Ser Gln Ser Leu Ser
    1630                1635                1640

 aat tca ttt aac tcc tct tac atg agt agc gac aat gag tca gat atc     5174
 Asn Ser Phe Asn Ser Ser Tyr Met Ser Ser Asp Asn Glu Ser Asp Ile
1645                1650                1655                1660

 gaa gat gaa gac tta aag tta gag ctg cga cga cta cga gat aaa cat     5222
 Glu Asp Glu Asp Leu Lys Leu Glu Leu Arg Arg Leu Arg Asp Lys His
                1665                1670                1675

 ctc aaa gag att cag gac ctg cag agt cgc cag aag cat gaa att gaa     5270
 Leu Lys Glu Ile Gln Asp Leu Gln Ser Arg Gln Lys His Glu Ile Glu
            1680                1685                1690

 tct ttg tat acc aaa ctg ggc aag gtg ccc cct gct gtt att att ccc     5318
 Ser Leu Tyr Thr Lys Leu Gly Lys Val Pro Pro Ala Val Ile Ile Pro
        1695                1700                1705

 cca gct gct ccc ctt tca ggg aga aga cga cga ccc act aaa agc aaa     5366
 Pro Ala Ala Pro Leu Ser Gly Arg Arg Arg Arg Pro Thr Lys Ser Lys
    1710                1715                1720

 ggc agc aaa tct agt cga agc agt tcc ttg ggg aat aaa agc ccc cag     5414
 Gly Ser Lys Ser Ser Arg Ser Ser Ser Leu Gly Asn Lys Ser Pro Gln
1725                1730                1735                1740

 ctt tca ggt aac ctg tct ggt cag agt gca gct tca gtc ttg cac ccc     5462
 Leu Ser Gly Asn Leu Ser Gly Gln Ser Ala Ala Ser Val Leu His Pro
                1745                1750                1755

 cag cag acc ctc cac cct cct ggc aac atc cca gag tcc ggg cag aat     5510
 Gln Gln Thr Leu His Pro Pro Gly Asn Ile Pro Glu Ser Gly Gln Asn
            1760                1765                1770

 cag ctg tta cag ccc ctt aag cca tct ccc tcc agt gac aac ctc tat     5558
 Gln Leu Leu Gln Pro Leu Lys Pro Ser Pro Ser Ser Asp Asn Leu Tyr
        1775                1780                1785

 tca gcc ttc acc agt gat ggt gcc att tca gta cca agc ctt tct gct     5606
 Ser Ala Phe Thr Ser Asp Gly Ala Ile Ser Val Pro Ser Leu Ser Ala
    1790                1795                1800

 cca ggt caa gga acc agc agc aca aac act gtt ggg gca aca gtg aac     5654
 Pro Gly Gln Gly Thr Ser Ser Thr Asn Thr Val Gly Ala Thr Val Asn
1805                1810                1815                1820

 agc caa gcc gcc caa gct cag cct cct gcc atg acg tcc agc agg aag     5702
 Ser Gln Ala Ala Gln Ala Gln Pro Pro Ala Met Thr Ser Ser Arg Lys
                1825                1830                1835

 ggc aca ttc aca gat gac ttg cac aag ttg gta gac aat tgg gcc cga     5750
 Gly Thr Phe Thr Asp Asp Leu His Lys Leu Val Asp Asn Trp Ala Arg
            1840                1845                1850

 gat gcc atg aat ctc tca ggc agg aga gga agc aaa ggg cac atg aat     5798
 Asp Ala Met Asn Leu Ser Gly Arg Arg Gly Ser Lys Gly His Met Asn
        1855                1860                1865

 tat gag ggc cct gga atg gca agg aag ttc tct gca cct ggg caa ctg     5846
 Tyr Glu Gly Pro Gly Met Ala Arg Lys Phe Ser Ala Pro Gly Gln Leu
    1870                1875                1880

 tgc atc tcc atg acc tcg aac ctg ggt ggc tct gcc ccc atc tct gca     5894
 Cys Ile Ser Met Thr Ser Asn Leu Gly Gly Ser Ala Pro Ile Ser Ala
1885                1890                1895                1900

 gca tca gct acc tct cta ggt cac ttc acc aag tct atg tgc ccc cca     5942
 Ala Ser Ala Thr Ser Leu Gly His Phe Thr Lys Ser Met Cys Pro Pro
                1905                1910                1915

 cag cag tat ggc ttt cca gct acc cca ttt ggc gct caa tgg agt ggg     5990
 Gln Gln Tyr Gly Phe Pro Ala Thr Pro Phe Gly Ala Gln Trp Ser Gly
            1920                1925                1930

 acg ggt ggc cca gca cca cag cca ctt ggc cag ttc aca act gtg gac     6038
 Thr Gly Gly Pro Ala Pro Gln Pro Leu Gly Gln Phe Thr Thr Val Asp
        1935                1940                1945

 aac tcg ctc ctt gcc gaa ttc caa cat cca gca atc tgc cga cac tcc     6086
 Asn Ser Leu Leu Ala Glu Phe Gln His Pro Ala Ile Cys Arg His Ser
    1950                1955                1960

 act cga aca aca cac caa ggg cat cca aac aag cgg aac cac att gaa     6134
 Thr Arg Thr Thr His Gln Gly His Pro Asn Lys Arg Asn His Ile Glu
1965                1970                1975                1980

 aca tag acaaacattt acctgcaaca tagaccacat ggaaggcaaa agcaaatatg      6190
 Thr 


 aactacctat acaggacaat aacatcacaa acatcgagca acaatacgcc aactattaat   6250

 taaaacactc acccgccgat tatcacagac ccaatctaat gcca                    6294




      <210> 674
      <211> 1483
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (380)..(823)

      <400> 674
 acatgcttac gccaagcttg gcacgaggca ttggtgcata tatcaataat taatttcctt     60

 ttattgctga gtagtattta ctatatggat gtaccacatt ttgtttatcc tttcaactgt    120

 tgctggacat ttgggttgtt tccagttttg agctatataa acaaagacac aaagatttgt    180

 atgtaaagca tcgtatggac agccacctta tttctcttgg agcagaaagg gaccttaaag    240

 atgacagacc aaacatcaac ttcacagatg atgacacaga aggtgaatct actgaaaaga    300

 gctaaagaaa gacaaatctc ttgaggcaga tgaagggaat gcaaatattc aaagaccctg    360

 cagaaaatca gtcaacaag atg ctg ttt gtc ttg gtc tta gtg ttt gct atc     412
                      Met Leu Phe Val Leu Val Leu Val Phe Ala Ile
                        1               5                  10

 tgt tgg gcc ccg ttc cac att gac cga ctc ttc ttc agc ttt gtg gag      460
 Cys Trp Ala Pro Phe His Ile Asp Arg Leu Phe Phe Ser Phe Val Glu
              15                  20                  25

 gag tgg agt gaa tcc ctg gct gct gtg ttc aac ctc gtc cat gtg gtg      508
 Glu Trp Ser Glu Ser Leu Ala Ala Val Phe Asn Leu Val His Val Val
          30                  35                  40

 tca ggt gtc ttc ttc tac ctg agc tca gct gtc aac ccc att atc tat      556
 Ser Gly Val Phe Phe Tyr Leu Ser Ser Ala Val Asn Pro Ile Ile Tyr
      45                  50                  55

 aac cta ctg tct cgc cgc ttc cag gca gca ttc cag aat gtg atc tct      604
 Asn Leu Leu Ser Arg Arg Phe Gln Ala Ala Phe Gln Asn Val Ile Ser
  60                  65                  70                  75

 tct ttc cac aaa cag tgg cac tcc cag cat gac cca cag ttg cca cct      652
 Ser Phe His Lys Gln Trp His Ser Gln His Asp Pro Gln Leu Pro Pro
                  80                  85                  90

 gcc cag cgg aac atc ttc ctg aca gaa tgc cac ttt gtg gag ctg acc      700
 Ala Gln Arg Asn Ile Phe Leu Thr Glu Cys His Phe Val Glu Leu Thr
              95                 100                 105

 gaa gat ata ggt ccc caa ttc cca tgt cag tca tcc atg cac aac tct      748
 Glu Asp Ile Gly Pro Gln Phe Pro Cys Gln Ser Ser Met His Asn Ser
         110                 115                 120

 cac ctc cca aca gcc ctc tct agt gaa cag atg tca aga aca aac tat      796
 His Leu Pro Thr Ala Leu Ser Ser Glu Gln Met Ser Arg Thr Asn Tyr
     125                 130                 135

 caa agc ttc cac ttt aac aaa acc tga attct ttcagagctg actctcctct      848
 Gln Ser Phe His Phe Asn Lys Thr 
 140                 145

 atgcctcaaa acttcagaga ggaacatccc ataatgtatg ccttctcata tgatattaga    908

 gaggtagaat ggctcttaca actcatgtac ccattgctag tttttttttt tttaataaac    968

 gtgaaaactg agagttagat ctggtttcaa aacccaagac tgcctgattt ttagttatct   1028

 ttccactatc ctaactgcct catgcccctt cactagttca tgccaagaac gtgactggaa   1088

 aggcatggca cctatacctt gattaatttc cattaatgga aatggttcgt cctgagtcat   1148

 ctacgttccg agtcaggctg tcactcctac taccaatggc cactgtgagc cacagaagga   1208

 agacatgtac gtgctgttct actttatatg atgtgagaag ccaacatcag tgtcccttgg   1268

 cagcagtcta caggcataac ttgttttatt gtgctgaatt ttattgtgct tctcaaatat   1328

 tgcactttta aaaaaattga aagtttgtgg caatgctgtt gagcaaatct gctggcatct   1388

 ttcttcccaa aggcatgtgc tcacttcatg tctctgtatc aattgtcata attttcgcaa   1448

 taaacttgat tattattaaa aaaaaaaaaa aaaaa                              1483




      <210> 675
      <211> 4711
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1718)..(3499)

      <400> 675
 gcgggatgaa acactttgtg agagaggagg tgtggggagt tgctatacgt gtttcgctct     60

 gtcgctctct gagtgattct tggccgcgtg gtagcctggg tggtgcactg gttaggcgca    120

 agtgggctca tcaactgttc aactctgccg ggctgttacc cgatcctagg cacggccatg    180

 tccccggcag aatggccgga ccttgaagga cagcttgtaa cggaccgcta gtgccatgga    240

 ggcaccctag gaattttaga tactgtctgt aaatggaatc atggataaca cagttgcttg    300

 tgtaccacag gccggtaagg acctgagttt tcaaggtccg gtgggctttc accagccaag    360

 tcctggaact ggtctagtct tggaaacaaa agcccagttt caggtcccca gcctcctccc    420

 ggtcaaaaag ggcatggatg tccatagaat cgaggcaaga aatagagctc tccaagactc    480

 ctctctgagg cagagacccc cagcctagac agcagcttgt cagctaggct tggggtgaca    540

 ggctgcagca aagtcccaaa gactcgcaaa cattccaagg ccacatgaag cacagtaccc    600

 agccagggag catccactgg gctctcccag ttcagcttcc atggtgcatg cctttggaca    660

 aaaccattag tttgccggac acagctggac acggcctcca gagccttata tatccgaaag    720

 ttatcatagt ggtctgctac ctgctttggc aaagtggcca ctgcgctcac cagagcataa    780

 tcctctgcct gagcacgaac tgacggcccc accaaccctg gctcactagg gaagcaggta    840

 gtgcagaagg ctgggtaggt ctcagaagga tttattcttt tggcagtgca tcggttcaag    900

 agacctccca aggcatctgc cagctcggag ttcagcaact taaccacctt ttcatcatag    960

 tagtcacagt cccagttggg gacgccctgc cgaaggagaa agtagcggaa gccatccacg   1020

 gtatagcggt taaggcaagt cctaggatcc accacgttgc ccaagctctt ggacatcttt   1080

 tggccacaga ctgtccagtg ggaatggaca cagatgcgct gtggcgggct catgccggcc   1140

 cctaacagga aggcaggcca atagatggca tggaatttga gaatgtcctt acctatgata   1200

 tgagaggtgg ccggccacca agatttgaac tcagcatttg ggtagccaat tacagtgagg   1260

 tagttgacca gggcatccag ccatacatag atggtctgcg aatcatcccc gggcaccgga   1320

 atgccccagt gcaagtggct acttctgcga gacacggaca ggtcgggcag ctcctcgtcc   1380

 agccactgaa gaactacgtg atgaaatggt tcgggggtga tcgcctgagg gttgccccgc   1440

 agccaccgct ggagtggctt ccggaactgg gaaagcctga aaatgtagtt ttcttccttg   1500

 gtccaggaga ctggatgccc gctctcgaga gatacaggaa acgaatcccc cgatgggccc   1560

 ggctgctggg tgaccttggc ctcaggcagg aagcactcgt cggaagcgca ataccaacct   1620

 tcatagacgc ccttgtagag cagaccgcgg gacttaagca ccccccagaa gtgctgcaca   1680

 gccacccggt gccgggcctc cgtggtgcgg atgaaat atg ctg cga acg tcc gtc    1735
                                          Met Leu Arg Thr Ser Val
                                            1               5

 ctc cgc ctg cta gga cgc acg ggg gct agt agg ctg tct ctc ctg gag     1783
 Leu Arg Leu Leu Gly Arg Thr Gly Ala Ser Arg Leu Ser Leu Leu Glu
              10                  15                  20

 gac ttc ggc cca cgc tac tac agt tcg ggc tcc ctc agt gcc ggc gat     1831
 Asp Phe Gly Pro Arg Tyr Tyr Ser Ser Gly Ser Leu Ser Ala Gly Asp
          25                  30                  35

 gat gct tgt gat gtg cgc gcc tac ttc act aca ccc att ttc tac gtg     1879
 Asp Ala Cys Asp Val Arg Ala Tyr Phe Thr Thr Pro Ile Phe Tyr Val
      40                  45                  50

 aac gcg gcg ccg cac atc ggg cac ctg tac tcg gca cta ctg gcg gac     1927
 Asn Ala Ala Pro His Ile Gly His Leu Tyr Ser Ala Leu Leu Ala Asp
  55                  60                  65                  70

 gcc cta tgc cgc cac cgt cgc ctc cga ggt ccc agc acg gcc gcc acg     1975
 Ala Leu Cys Arg His Arg Arg Leu Arg Gly Pro Ser Thr Ala Ala Thr
                  75                  80                  85

 cga ttc tcc act ggt acc gac gag cac ggg ctg aag att cag cag gca     2023
 Arg Phe Ser Thr Gly Thr Asp Glu His Gly Leu Lys Ile Gln Gln Ala
              90                  95                 100

 gca gct acc gcg ggc ctg gcc ccg acc gag ctg tgc gac cga gtc tct     2071
 Ala Ala Thr Ala Gly Leu Ala Pro Thr Glu Leu Cys Asp Arg Val Ser
         105                 110                 115

 gag cag ttc cag cag ctt ttc cag gag gcc ggt atc tcc tgc aca gat     2119
 Glu Gln Phe Gln Gln Leu Phe Gln Glu Ala Gly Ile Ser Cys Thr Asp
     120                 125                 130

 ttc atc cgc acc acg gag gcc cgg cac cgg gtg gct gtg cag cac ttc     2167
 Phe Ile Arg Thr Thr Glu Ala Arg His Arg Val Ala Val Gln His Phe
 135                 140                 145                 150

 tgg ggg gtg ctt aag tcc cgc ggt ctg ctc tac aag ggc gtc tat gaa     2215
 Trp Gly Val Leu Lys Ser Arg Gly Leu Leu Tyr Lys Gly Val Tyr Glu
                 155                 160                 165

 ggt cgg tat agc gct tcc gac gag tgc ttc ctg cct gag gcc aag gtc     2263
 Gly Arg Tyr Ser Ala Ser Asp Glu Cys Phe Leu Pro Glu Ala Lys Val
             170                 175                 180

 acc cag cag cgg gcc cat cgg ggg att cgt ttc ctg tat cta ctc gag     2311
 Thr Gln Gln Arg Ala His Arg Gly Ile Arg Phe Leu Tyr Leu Leu Glu
         185                 190                 195

 agc ggg cat cca gtc tcc tgg acc aag gaa gaa aac tac att ttc agg     2359
 Ser Gly His Pro Val Ser Trp Thr Lys Glu Glu Asn Tyr Ile Phe Arg
     200                 205                 210

 ctt tcc cag ttc cgg aag cca ctc cag cgg tgg ctg cgg ggc aac cct     2407
 Leu Ser Gln Phe Arg Lys Pro Leu Gln Arg Trp Leu Arg Gly Asn Pro
 215                 220                 225                 230

 cag gcg atc acc ccc gaa cca ttt cat cac gta gtt ctt cag tgg ctg     2455
 Gln Ala Ile Thr Pro Glu Pro Phe His His Val Val Leu Gln Trp Leu
                 235                 240                 245

 gac gag gag ctg ccc gac ctg tcc gtg tct cgc aga agt agc cac ttg     2503
 Asp Glu Glu Leu Pro Asp Leu Ser Val Ser Arg Arg Ser Ser His Leu
             250                 255                 260

 cac tgg ggc att ccg gtg ccc ggg gat gat tcg cag acc atc tat gta     2551
 His Trp Gly Ile Pro Val Pro Gly Asp Asp Ser Gln Thr Ile Tyr Val
         265                 270                 275

 tgg ctg gat gcc ctg gtc aac tac ctc act gta att ggc tac cca aat     2599
 Trp Leu Asp Ala Leu Val Asn Tyr Leu Thr Val Ile Gly Tyr Pro Asn
     280                 285                 290

 gct gag ttc aaa tct tgg tgg ccg gcc acc tct cat atc ata ggt aag     2647
 Ala Glu Phe Lys Ser Trp Trp Pro Ala Thr Ser His Ile Ile Gly Lys
 295                 300                 305                 310

 gac att ctc aaa ttc cat gcc atc tat tgg cct gcc ttc ctg tta ggg     2695
 Asp Ile Leu Lys Phe His Ala Ile Tyr Trp Pro Ala Phe Leu Leu Gly
                 315                 320                 325

 gcc ggc atg agc ccg cca cag cgc atc tgt gtc cat tcc cac tgg aca     2743
 Ala Gly Met Ser Pro Pro Gln Arg Ile Cys Val His Ser His Trp Thr
             330                 335                 340

 gtc tgt ggc caa aag atg tcc aag agc ttg ggc aac gtg gtg gat cct     2791
 Val Cys Gly Gln Lys Met Ser Lys Ser Leu Gly Asn Val Val Asp Pro
         345                 350                 355

 agg act tgc ctt aac cgc tat acc gtg gat ggc ttc cgc tac ttt ctc     2839
 Arg Thr Cys Leu Asn Arg Tyr Thr Val Asp Gly Phe Arg Tyr Phe Leu
     360                 365                 370

 ctt cgg cag ggc gtc ccc aac tgg gac tgt gac tac tat gat gaa aag     2887
 Leu Arg Gln Gly Val Pro Asn Trp Asp Cys Asp Tyr Tyr Asp Glu Lys
 375                 380                 385                 390

 gtg gtt aag ttg ctg aac tcc gag ctg gca gat gcc ttg gga ggt ctc     2935
 Val Val Lys Leu Leu Asn Ser Glu Leu Ala Asp Ala Leu Gly Gly Leu
                 395                 400                 405

 ttg aac cga tgc act gcc aaa aga ata aat cct tct gag acc tac cca     2983
 Leu Asn Arg Cys Thr Ala Lys Arg Ile Asn Pro Ser Glu Thr Tyr Pro
             410                 415                 420

 gcc ttc tgc act acc tgc ttc cct agt gag cca ggg ttg gtg ggg ccg     3031
 Ala Phe Cys Thr Thr Cys Phe Pro Ser Glu Pro Gly Leu Val Gly Pro
         425                 430                 435

 tca gtt cgt gct cag gca gag gat tat gct ctg gtg agc gca gtg gcc     3079
 Ser Val Arg Ala Gln Ala Glu Asp Tyr Ala Leu Val Ser Ala Val Ala
     440                 445                 450

 act ttg cca aag cag gta gca gac cac tat gat aac ttt cgg ata tat     3127
 Thr Leu Pro Lys Gln Val Ala Asp His Tyr Asp Asn Phe Arg Ile Tyr
 455                 460                 465                 470

 aag gct ctg gag gcc gtg tcc agc tgt gtc cgg caa act aat ggt ttt     3175
 Lys Ala Leu Glu Ala Val Ser Ser Cys Val Arg Gln Thr Asn Gly Phe
                 475                 480                 485

 gtc caa agg cat gca cca tgg aag ctg aac tgg aag agc cca gtg gat     3223
 Val Gln Arg His Ala Pro Trp Lys Leu Asn Trp Lys Ser Pro Val Asp
             490                 495                 500

 gct ccc tgg ctg ggt act gtg ctt cat gtg gcc ttg gaa tgt ttg cga     3271
 Ala Pro Trp Leu Gly Thr Val Leu His Val Ala Leu Glu Cys Leu Arg
         505                 510                 515

 gtc ttt ggg act ttg ctg cag cct gtc acc cca agc cta gct gac aag     3319
 Val Phe Gly Thr Leu Leu Gln Pro Val Thr Pro Ser Leu Ala Asp Lys
     520                 525                 530

 ctg ctg tct agg ctg ggg gtc tct gcc tca gag agg agt ctt gga gag     3367
 Leu Leu Ser Arg Leu Gly Val Ser Ala Ser Glu Arg Ser Leu Gly Glu
 535                 540                 545                 550

 ctc tat ttc ttg cct cga ttc tat gga cat cca tgc cct ttt gaa ggg     3415
 Leu Tyr Phe Leu Pro Arg Phe Tyr Gly His Pro Cys Pro Phe Glu Gly
                 555                 560                 565

 agg agg ctg gga cct gaa act ggg ctt ttg ttt cca aga cta gac cag     3463
 Arg Arg Leu Gly Pro Glu Thr Gly Leu Leu Phe Pro Arg Leu Asp Gln
             570                 575                 580

 tcc agg act tgg ctg gtg aaa gcc cac cgg acc tag aaac tcagttctta     3513
 Ser Arg Thr Trp Leu Val Lys Ala His Arg Thr 
         585                 590

 ccggcttgtg gtaaaaaagc aaatgtgtta tctttttatt ttttattttc aggaaagtta   3573

 tactagtatt ttcttaagtg tggaatcaaa tgagcacata agctgtgtcc ctgtgaaaag   3633

 aggtttgtag cctttcaggt gcctgctcct attcttcatt tctctgtgac cattgatcac   3693

 tgtcctttgt gcattgtgtg tctaagatgt cttcagggga aagatgggta agagacagtg   3753

 ttgctaatgc tgttccttct ttgtgcctcc ttccaaacca cagttatttg cccaaactac   3813

 ctctcgtggc tggtttttca ttggcctggc ctctgcttct caggctaatt agtgactcct   3873

 ttctttgagg gtcagggttg gaggcccctt actggtggtt ttacaggggg atcctacttt   3933

 gttacacatg ttgggtttcc tgataaaaag agagtatttt attaaaccct tgaaccagtg   3993

 tcctagacca gatgattttt gcccatgtgt atccccattt aaattcctac aactaagtct   4053

 ccctgctttg ttaatagtcc aacagttggg ttgtgtaaca tcacacttca accggtagat   4113

 ggctctaatc tcacacattt acttactaaa gattgaggat tcggaatatt tagaataaat   4173

 tagttttctg ctttctaatt ttgcagatct ttacattttt attgcttttc ttaaaataag   4233

 ggatagcttt gcaaccacta ttgttttaat ggaaagcaaa aaaccccccc aaacttatca   4293

 gaatcctcgt tctttttcag actactgaaa aatgacattt actctgttaa atgtttaata   4353

 agtgaataag taaatgtatc aagttgttta tataataaat tataaaactc ttgaggcact   4413

 tggtatgtta aaaattttaa actttagtaa cattaggtta caggtatgat ttaaaaattt   4473

 gtaaatagtt caaaagggca atgttttctt tatatttctt atagtcttaa ttttgttatc   4533

 catgtgcata atttacctca tgatttcttt tggtcaatca ggatctttaa tacaatatag   4593

 aaattgtgta atagttatta taaatgttaa tacacaactt tcaggtaatt ttaactgatt   4653

 atttcttttg ctcttttaac ttaagttatt aaagtttaaa agttcgtaaa aaaaaaaa     4711




      <210> 676
      <211> 1234
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (102)..(575)

      <400> 676
 tgactgatag tgacctgttc gttgaacaaa ttgatgagca atgctttttt ataatgccaa     60

 ctttgtacaa aaaagcaggc tttaattaag gaggtaacac c    atg atg atc ctg     113
                                                  Met Met Ile Leu
                                                    1

 cag gtt tca ggg ggc ccc tgg aca gtg gct ctg aca gca tta ctg atg      161
 Gln Val Ser Gly Gly Pro Trp Thr Val Ala Leu Thr Ala Leu Leu Met
   5                  10                  15                  20

 gtg ctg ctc ata tct gtg gtc cag agc agg gcc act cca gag aat tcc      209
 Val Leu Leu Ile Ser Val Val Gln Ser Arg Ala Thr Pro Glu Asn Ser
                  25                  30                  35

 gtc tac cag gaa cgg cag gaa tgc tat gcg ttc aat ggg act cag cgc      257
 Val Tyr Gln Glu Arg Gln Glu Cys Tyr Ala Phe Asn Gly Thr Gln Arg
              40                  45                  50

 gtt gtg gac ggg ctc atc tac aac cgg gag gaa tac gtg cat ttt gac      305
 Val Val Asp Gly Leu Ile Tyr Asn Arg Glu Glu Tyr Val His Phe Asp
          55                  60                  65

 agc gca gtg ggg gag ttc cta gca gtg atg gag ctg ggg cgg ccc ata      353
 Ser Ala Val Gly Glu Phe Leu Ala Val Met Glu Leu Gly Arg Pro Ile
      70                  75                  80

 ggc gag tac ttc aat agc cag aag gac ttt atg gaa cgg aag cga gcc      401
 Gly Glu Tyr Phe Asn Ser Gln Lys Asp Phe Met Glu Arg Lys Arg Ala
  85                  90                  95                 100

 gag gtg gac aag gtg tgc aga cac aag tac gag ctg atg gag cca ctc      449
 Glu Val Asp Lys Val Cys Arg His Lys Tyr Glu Leu Met Glu Pro Leu
                 105                 110                 115

 atc cgg cag cgc cga gga gac gta acc ata act gct gtt agg ggg tgt      497
 Ile Arg Gln Arg Arg Gly Asp Val Thr Ile Thr Ala Val Arg Gly Cys
             120                 125                 130

 tgg acg acg att ctt tct ggc tac ttc ctg ctg aaa agg ggc gtc gtg      545
 Trp Thr Thr Ile Leu Ser Gly Tyr Phe Leu Leu Lys Arg Gly Val Val
         135                 140                 145

 tcg ggg ggc tgc agt tgg ggc tcc tcc tga g gttgatctaa ggcttcttgg      596
 Ser Gly Gly Cys Ser Trp Gly Ser Ser 
     150                 155

 aagaatggca tgtccatgtg tggctttgtt tgcagcacca tttgaagttt gattgcttct    656

 aggcaaaaag agataaattt tacaagaagg tttaaaatat agggttacca tatgagtatt    716

 aagattacca cctatagact gtaactatgg cagtagagtt tgatacctgt tacaccaatg    776

 gattgtaata ctggtttgtc tccactagat gtcgctgtac attaccagaa acgttaatat    836

 aaaagcatca tttcctttga gaaaacatgt ttcccccttg acttgctatt agggcataat    896

 ttttggttta ggccattctt tataacttat gatatgattg ggagaaaaac gttattgggt    956

 ggctaaaata actttggtgt taatcttggc aattcctttc ctttaattat taaatttctt   1016

 aattattaaa ttctttcatg actttcacag accctcttac aatgtactca actttctgac   1076

 ttgtcttaaa caaccagtca tttcctttta ggacaagaat ttactataca agatcctttc   1136

 ttatataaaa tccctttatt tgtaaccttc tttccatagc ttagagtgca ccatttacca   1196

 atcttcaata aaaaagtcct atcaaaaaaa aaaaaaaa                           1234




      <210> 677
      <211> 911
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(658)

      <400> 677
 gttggttggc cggcggcggg ccgggacggg c   atg gcc ctg ctg ctg tgc ctg      52
                                      Met Ala Leu Leu Leu Cys Leu
                                        1               5

 gtg tgc ctg acg gcg gcg ctg gcc cac ggc tgt ctg cac tgc cac agc      100
 Val Cys Leu Thr Ala Ala Leu Ala His Gly Cys Leu His Cys His Ser
          10                  15                  20

 aac ttc tcc aag aag ttc tcc ttc tac cgc cac cat gtg aac ttc aag      148
 Asn Phe Ser Lys Lys Phe Ser Phe Tyr Arg His His Val Asn Phe Lys
      25                  30                  35

 tcc tgg tgg gtg ggc gac atc ccc gtg tca ggg gcg ctg ctc acc gac      196
 Ser Trp Trp Val Gly Asp Ile Pro Val Ser Gly Ala Leu Leu Thr Asp
  40                  45                  50                  55

 tgg agc gac gac acg atg aag gag ctg cac ctg gcc atc ccc gcc aag      244
 Trp Ser Asp Asp Thr Met Lys Glu Leu His Leu Ala Ile Pro Ala Lys
                  60                  65                  70

 atc acc cgg gag aag ctg gac caa gtg gcg aca gca gtg tac cag atg      292
 Ile Thr Arg Glu Lys Leu Asp Gln Val Ala Thr Ala Val Tyr Gln Met
              75                  80                  85

 atg gat cag ctg tac cag ggg aag atg tac ttc ccc ggg tat ttc ccc      340
 Met Asp Gln Leu Tyr Gln Gly Lys Met Tyr Phe Pro Gly Tyr Phe Pro
          90                  95                 100

 aac gag ctg cga aac atc ttc cgg gag cag gtg cac ctc atc cag aac      388
 Asn Glu Leu Arg Asn Ile Phe Arg Glu Gln Val His Leu Ile Gln Asn
     105                 110                 115

 gcc atc atc gaa agc cgc atc gac tgt cag cac cgc tgt ggc atc ttc      436
 Ala Ile Ile Glu Ser Arg Ile Asp Cys Gln His Arg Cys Gly Ile Phe
 120                 125                 130                 135

 cag tac gag acc atc tcc tgc aac aac tgc aca gac tcg cac gtc gcc      484
 Gln Tyr Glu Thr Ile Ser Cys Asn Asn Cys Thr Asp Ser His Val Ala
                 140                 145                 150

 tgc ttt ggc tat aac tgc gag tcc tcg gcg cag tgg aag tca gct gtc      532
 Cys Phe Gly Tyr Asn Cys Glu Ser Ser Ala Gln Trp Lys Ser Ala Val
             155                 160                 165

 cag ggc ctc ctg aac tac ata aat aac tgg cac aac ctg gta tcg cca      580
 Gln Gly Leu Leu Asn Tyr Ile Asn Asn Trp His Asn Leu Val Ser Pro
         170                 175                 180

 gcc tta agg tgt ctg gag ccc cca cac ttg gcc aac ctg acc ttg gaa      628
 Ala Leu Arg Cys Leu Glu Pro Pro His Leu Ala Asn Leu Thr Leu Glu
     185                 190                 195

 gat gct gct gag tgt ctc aag cag cac tga c agcagctggg cctgcctcag      679
 Asp Ala Ala Glu Cys Leu Lys Gln His 
 200                 205

 ggcaacgtgg gggcggagac tcagctggac agcccctgcc tgtcactctg gagctgggct    739

 gctgctgcct caggaccccc tctccgaccc cggacagagc tgagctggcc agggccagga    799

 gggcgggagg gagggaatgg gggtgggctg tgcgcagcat cagcgcctgg gcaggtccgc    859

 agagctgcgg gatgtgatta aagtccctga tgtttctctt tgaaaaaaaa aa            911




      <210> 678
      <211> 983
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (92)..(736)

      <400> 678
 atttgaacct tgagaaccta ctcagtgtcg tggaattaag ggtgtggcgc gagcagcgtc     60

 gttggttggc cggcggcggg ccgggacggg c   atg gcc ctg ctg ctg tgc ctg     112
                                      Met Ala Leu Leu Leu Cys Leu
                                        1               5

 gtg tgc ctg acg gcg gcg ctg gcc cac ggc tgt ctg cac tgc cac agc      160
 Val Cys Leu Thr Ala Ala Leu Ala His Gly Cys Leu His Cys His Ser
          10                  15                  20

 aac ttc tcc aag aag ttc tcc ttc tac cgc cac cat gtg aac ttc aag      208
 Asn Phe Ser Lys Lys Phe Ser Phe Tyr Arg His His Val Asn Phe Lys
      25                  30                  35

 tcc tgg tgg gtg ggc gac atc ccc gtg tca ggg gcg ctg ctc acc gac      256
 Ser Trp Trp Val Gly Asp Ile Pro Val Ser Gly Ala Leu Leu Thr Asp
  40                  45                  50                  55

 tgg agc gac gac acg atg aag gag ctg cac ctg gcc atc ccc gcc aag      304
 Trp Ser Asp Asp Thr Met Lys Glu Leu His Leu Ala Ile Pro Ala Lys
                  60                  65                  70

 atc acc cgg gag aag ctg gac caa gtg gcg aca gca gtg tac cag atg      352
 Ile Thr Arg Glu Lys Leu Asp Gln Val Ala Thr Ala Val Tyr Gln Met
              75                  80                  85

 atg gat cag ctg tac cag ggg aag atg tac ttc ccc ggg tat ttc ccc      400
 Met Asp Gln Leu Tyr Gln Gly Lys Met Tyr Phe Pro Gly Tyr Phe Pro
          90                  95                 100

 aac gag ctg cga aac atc ttc cgg gag cag gtg cac ctc atc cag aac      448
 Asn Glu Leu Arg Asn Ile Phe Arg Glu Gln Val His Leu Ile Gln Asn
     105                 110                 115

 gcc atc atc gaa agc cgc atc gac tgt cag cac cgc tgt ggc atc ttc      496
 Ala Ile Ile Glu Ser Arg Ile Asp Cys Gln His Arg Cys Gly Ile Phe
 120                 125                 130                 135

 cag tac gag acc atc tcc tgc aac aac tgc aca gac tcg cac gtc gcc      544
 Gln Tyr Glu Thr Ile Ser Cys Asn Asn Cys Thr Asp Ser His Val Ala
                 140                 145                 150

 tgc ttt ggc tat aac tgc gag tcc tcg gcg cag tgg aag tca gct gtc      592
 Cys Phe Gly Tyr Asn Cys Glu Ser Ser Ala Gln Trp Lys Ser Ala Val
             155                 160                 165

 cag ggc ctc ctg aac tac ata aat aac tgg cac aaa cag gac acg agc      640
 Gln Gly Leu Leu Asn Tyr Ile Asn Asn Trp His Lys Gln Asp Thr Ser
         170                 175                 180

 atg agc ctg gta tcg cca gcc tta agg tgt ctg gag ccc cca cac ttg      688
 Met Ser Leu Val Ser Pro Ala Leu Arg Cys Leu Glu Pro Pro His Leu
     185                 190                 195

 gcc aac ctg acc ttg gaa gat gct gct gag tgt ctc aag cag cac tga      736
 Ala Asn Leu Thr Leu Glu Asp Ala Ala Glu Cys Leu Lys Gln His 
 200                 205                 210

 cagcagctgg gcctgcccca gggcaacgtg ggggcggaga ctcagctgga cagcccctgc    796

 ctgtcactct ggagctgggc tgctgctgcc tcaggacccc ctctccgacc ccggacagag    856

 ctgagctggc cagggccagg agggcgggag ggagggaatg ggggtgggct gtgcgcagca    916

 tcagcgcctg ggcaggtccg cagagctgcg ggatgtgatt aaagtccctg atgtttcaaa    976

 aaaaaaa                                                              983




      <210> 679
      <211> 2144
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (210)..(1847)

      <400> 679
 agagaagaac cctgaggaac agacttacct cagcaaccct ggcacctcca acccgacaca     60

 tgctactgct gctgctactg ctgccacccc tgctctgtgg gagagtgggg gctaaggaac    120

 agaaggatta cctgctgaca atgcagaagt ccgtgacggt gcaggagggc ctgtgtgtct    180

 ctgtgctttg ctccttctcc tacccccaa  aat ggc tgg act gcc tcc gat cca     233
                                  Asn Gly Trp Thr Ala Ser Asp Pro
                                    1               5

 gtt cat ggc tac tgg ttc cgg gca ggg gac cat gta agc cgg aac att      281
 Val His Gly Tyr Trp Phe Arg Ala Gly Asp His Val Ser Arg Asn Ile
      10                  15                  20

 cca gtg gcc aca aac aac cca gct cga gca gtg cag gag gag act cgg      329
 Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val Gln Glu Glu Thr Arg
  25                  30                  35                  40

 gac cga ttc cac ctc ctt ggg gac cca cag aac aag gat tgt acc ctg      377
 Asp Arg Phe His Leu Leu Gly Asp Pro Gln Asn Lys Asp Cys Thr Leu
                  45                  50                  55

 agc atc aga gac acc aga gag agt gat gca ggg aca tac gtc ttt tgt      425
 Ser Ile Arg Asp Thr Arg Glu Ser Asp Ala Gly Thr Tyr Val Phe Cys
              60                  65                  70

 gta gag aga gga aat atg aaa tgg aat tat aaa tat gac cag ctc tct      473
 Val Glu Arg Gly Asn Met Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser
          75                  80                  85

 gtg aat gtg aca gcg tcc cag gac cta ctg tca aga tac agg ctg gag      521
 Val Asn Val Thr Ala Ser Gln Asp Leu Leu Ser Arg Tyr Arg Leu Glu
      90                  95                 100

 gtg cca gag tcg gtg act gtg cag gag ggt ctg tgt gtc tct gtg ccc      569
 Val Pro Glu Ser Val Thr Val Gln Glu Gly Leu Cys Val Ser Val Pro
 105                 110                 115                 120

 tgc agt gtc ctt tac ccc cat tac aac tgg act gcc tct agc cct gtt      617
 Cys Ser Val Leu Tyr Pro His Tyr Asn Trp Thr Ala Ser Ser Pro Val
                 125                 130                 135

 tat gga tcc tgg gtc aag gaa ggg gcc gat ata cca tgg gat att cca      665
 Tyr Gly Ser Trp Val Lys Glu Gly Ala Asp Ile Pro Trp Asp Ile Pro
             140                 145                 150

 gtg gcc aca aac acc cca agt gga aaa gtg caa gag gat acc cag ggt      713
 Val Ala Thr Asn Thr Pro Ser Gly Lys Val Gln Glu Asp Thr Gln Gly
         155                 160                 165

 cga ttc ctc ctc ctt ggg gac cca cag acc aac aac tgc tcc ctg agc      761
 Arg Phe Leu Leu Leu Gly Asp Pro Gln Thr Asn Asn Cys Ser Leu Ser
     170                 175                 180

 atc aga gat gcc agg aag ggg gat tca ggg aag tac tac ttc cag gtg      809
 Ile Arg Asp Ala Arg Lys Gly Asp Ser Gly Lys Tyr Tyr Phe Gln Val
 185                 190                 195                 200

 gag aga gga agc agg aaa tgg aac tac ata tat gac aag ctc tct gtg      857
 Glu Arg Gly Ser Arg Lys Trp Asn Tyr Ile Tyr Asp Lys Leu Ser Val
                 205                 210                 215

 cat gtg aca gcc ctg act cac atg ccc acc ttc tcc atc ccg ggg acc      905
 His Val Thr Ala Leu Thr His Met Pro Thr Phe Ser Ile Pro Gly Thr
             220                 225                 230

 ctg gag tct ggc cac ccc agg aac ctg acc tgc tct gtg ccc tgg gcc      953
 Leu Glu Ser Gly His Pro Arg Asn Leu Thr Cys Ser Val Pro Trp Ala
         235                 240                 245

 tgt gaa cag ggg acg ccc ccc acg atc acc tgg atg ggg gcc tcc gtg     1001
 Cys Glu Gln Gly Thr Pro Pro Thr Ile Thr Trp Met Gly Ala Ser Val
     250                 255                 260

 tcc tcc ctg aat ccc aat atc act cgc tcc tcg atg ctc agc ctc atc     1049
 Ser Ser Leu Asn Pro Asn Ile Thr Arg Ser Ser Met Leu Ser Leu Ile
 265                 270                 275                 280

 cca cag ccc cag gac cat ggc acc agc ctc acc tgt cag gtg acc ttg     1097
 Pro Gln Pro Gln Asp His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu
                 285                 290                 295

 cct ggg gcc ggt gtg acc atg acc agg gct gtc cga ctc aac ata tcc     1145
 Pro Gly Ala Gly Val Thr Met Thr Arg Ala Val Arg Leu Asn Ile Ser
             300                 305                 310

 tat cct cct cag aac ttg acc atg act gtc ttc caa gga gat ggc aca     1193
 Tyr Pro Pro Gln Asn Leu Thr Met Thr Val Phe Gln Gly Asp Gly Thr
         315                 320                 325

 gca tcc aca acc ttg agg aat ggc tcg gcc ctt tca gtc ctg gag ggc     1241
 Ala Ser Thr Thr Leu Arg Asn Gly Ser Ala Leu Ser Val Leu Glu Gly
     330                 335                 340

 cag tcc ctg cac ctt gtc tgt gct gtc gac agc aat ccc cct gcc agg     1289
 Gln Ser Leu His Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg
 345                 350                 355                 360

 ctg agc tgg acc tgg ggg agc ctg acc ctg agc ccc tca cag tcc tcg     1337
 Leu Ser Trp Thr Trp Gly Ser Leu Thr Leu Ser Pro Ser Gln Ser Ser
                 365                 370                 375

 aac ctt ggg gtg ctg gag ctg cct cga gtg cat gtg aag gat gaa ggg     1385
 Asn Leu Gly Val Leu Glu Leu Pro Arg Val His Val Lys Asp Glu Gly
             380                 385                 390

 gaa ttc acc tgc cga gct cag aac cct cta ggc tcc cag cac att tcc     1433
 Glu Phe Thr Cys Arg Ala Gln Asn Pro Leu Gly Ser Gln His Ile Ser
         395                 400                 405

 ctg agc ctc tcc ctg caa aac gag tac aca ggc aaa atg agg cct ata     1481
 Leu Ser Leu Ser Leu Gln Asn Glu Tyr Thr Gly Lys Met Arg Pro Ile
     410                 415                 420

 tca gga gtg acg cta ggg gca ttc ggg gga gct gga gcc aca gcc ctg     1529
 Ser Gly Val Thr Leu Gly Ala Phe Gly Gly Ala Gly Ala Thr Ala Leu
 425                 430                 435                 440

 gtc ttc ctg tcc ttc tgc atc atc ttc gtt gta gtg agg tcc tgc agg     1577
 Val Phe Leu Ser Phe Cys Ile Ile Phe Val Val Val Arg Ser Cys Arg
                 445                 450                 455

 aag aaa tcg gca agg cca gca gtg ggc gtg ggg gat aca ggc atg gag     1625
 Lys Lys Ser Ala Arg Pro Ala Val Gly Val Gly Asp Thr Gly Met Glu
             460                 465                 470

 gac gca aac gct gtc agg ggc tca gcc tct cag gga ccc ctg att gaa     1673
 Asp Ala Asn Ala Val Arg Gly Ser Ala Ser Gln Gly Pro Leu Ile Glu
         475                 480                 485

 tcc ccg gca gat gac agc ccc cca cac cat gct ccg cca gcc ctg gcc     1721
 Ser Pro Ala Asp Asp Ser Pro Pro His His Ala Pro Pro Ala Leu Ala
     490                 495                 500

 acc ccc tcc cca gag gaa gga gag atc cag tat gca tcc ctc agc ttc     1769
 Thr Pro Ser Pro Glu Glu Gly Glu Ile Gln Tyr Ala Ser Leu Ser Phe
 505                 510                 515                 520

 cac aaa gcg agg cct cag tac cca cag gaa cag gag gcc atc ggc tat     1817
 His Lys Ala Arg Pro Gln Tyr Pro Gln Glu Gln Glu Ala Ile Gly Tyr
                 525                 530                 535

 gag tac tcc gag atc aac atc ccc aag tga g aaactgcaga gactcaggcc     1868
 Glu Tyr Ser Glu Ile Asn Ile Pro Lys 
             540                 545

 tgtttgaggg ctcacgaccc ctgcagcaaa gaagcccgag actgattcct ttagaattaa   1928

 cagccctcca tgctgtgcaa caggacatca gaacttattc ctcttgtcaa actgaaaatg   1988

 cgtgcctgat gaccaaactc tccctttctc catccaatcg gtccacactc cccgcccccg   2048

 ggctctggta cccaccattc tcttctctac ttctctgagg tcgactattt taggttccaa   2108

 atatagtgag atcgtagagt gttaaaaaaa aaaaaa                             2144




      <210> 680
      <211> 1887
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (233)..(1168)

      <400> 680
 ggaactctcc taggccactc cctgctgatg caacatctgg gtttgggcag aaaggagggt     60

 gcttcggagc ccgccctttc tgagcttcct gggccggctc tagaacaatt caggcttcgc    120

 tgcgactcag acctcagctc caacatatgc attctgaaga aagatggctg agatggacag    180

 aatgctttat tttggaaaga aacaatgttc taggtcaaac tgagtctacc aa    atg     235
                                                              Met
                                                                1

 cag act ttc aca atg gtt cta gaa gaa atc tgg aca agt ctt ttc atg      283
 Gln Thr Phe Thr Met Val Leu Glu Glu Ile Trp Thr Ser Leu Phe Met
               5                  10                  15

 tgg ttt ttc tac gca ttg att cca tgt ttg ctc aca gat gaa gtg gcc      331
 Trp Phe Phe Tyr Ala Leu Ile Pro Cys Leu Leu Thr Asp Glu Val Ala
          20                  25                  30

 att ctg cct gcc cct cag aac ctc tct gta ctc tca acc aac atg aag      379
 Ile Leu Pro Ala Pro Gln Asn Leu Ser Val Leu Ser Thr Asn Met Lys
      35                  40                  45

 cat ctc ttg atg tgg agc cca gtg atc gcg cct gga gaa aca gtg tac      427
 His Leu Leu Met Trp Ser Pro Val Ile Ala Pro Gly Glu Thr Val Tyr
  50                  55                  60                  65

 tat tct gtc gaa tac cag ggg gag tac gag agc ctg tac acg agc cac      475
 Tyr Ser Val Glu Tyr Gln Gly Glu Tyr Glu Ser Leu Tyr Thr Ser His
                  70                  75                  80

 atc tgg atc ccc agc agc tgg tgc tca ctc act gaa ggt cct gag tgt      523
 Ile Trp Ile Pro Ser Ser Trp Cys Ser Leu Thr Glu Gly Pro Glu Cys
              85                  90                  95

 gat gtc act gat gac atc acg gcc act gtg cca tac aac ctt cgt gtc      571
 Asp Val Thr Asp Asp Ile Thr Ala Thr Val Pro Tyr Asn Leu Arg Val
         100                 105                 110

 agg gcc aca ttg ggc tca cag acc tca gcc tgg agc atc ctg aag cat      619
 Arg Ala Thr Leu Gly Ser Gln Thr Ser Ala Trp Ser Ile Leu Lys His
     115                 120                 125

 ccc ttt aat aga aac tca acc atc ctt acc cga cct ggg atg gag atc      667
 Pro Phe Asn Arg Asn Ser Thr Ile Leu Thr Arg Pro Gly Met Glu Ile
 130                 135                 140                 145

 acc aaa gat ggc ttc cac ctg gtt att gag ctg gag gac ctg ggg ccc      715
 Thr Lys Asp Gly Phe His Leu Val Ile Glu Leu Glu Asp Leu Gly Pro
                 150                 155                 160

 cag ttt gag ttc ctt gtg gcc tac tgg agg agg gag cct ggt gcc gag      763
 Gln Phe Glu Phe Leu Val Ala Tyr Trp Arg Arg Glu Pro Gly Ala Glu
             165                 170                 175

 gaa cat gtc aaa atg gtg agg agt ggg ggt att cca gtg cac cta gaa      811
 Glu His Val Lys Met Val Arg Ser Gly Gly Ile Pro Val His Leu Glu
         180                 185                 190

 acc atg gag cca ggg gct gca tac tgt gtg aag gcc cag aca ttc gtg      859
 Thr Met Glu Pro Gly Ala Ala Tyr Cys Val Lys Ala Gln Thr Phe Val
     195                 200                 205

 aag gcc att ggg agg tac agc gcc ttc agc cag aca gaa tgt gtg gag      907
 Lys Ala Ile Gly Arg Tyr Ser Ala Phe Ser Gln Thr Glu Cys Val Glu
 210                 215                 220                 225

 gtg caa gga gag gcc att ccc ctg gta ctg gcc ctg ttt gcc ttt gtt      955
 Val Gln Gly Glu Ala Ile Pro Leu Val Leu Ala Leu Phe Ala Phe Val
                 230                 235                 240

 ggc ttc atg ctg atc ctt gtg gtc gtg cca ctg ttc gtc tgg aaa atg     1003
 Gly Phe Met Leu Ile Leu Val Val Val Pro Leu Phe Val Trp Lys Met
             245                 250                 255

 ggc cgg ctg ctc cag tac tcc tgt tgc ccc gtg gtg gtc ctc cca gac     1051
 Gly Arg Leu Leu Gln Tyr Ser Cys Cys Pro Val Val Val Leu Pro Asp
         260                 265                 270

 acc ttg aaa ata acc aat tca ccc cag aag tta atc agc tgc aga agg     1099
 Thr Leu Lys Ile Thr Asn Ser Pro Gln Lys Leu Ile Ser Cys Arg Arg
     275                 280                 285

 gag gag gtg gat gcc tgt gcc acg gct gtg atg tct cct gag gaa ctc     1147
 Glu Glu Val Asp Ala Cys Ala Thr Ala Val Met Ser Pro Glu Glu Leu
 290                 295                 300                 305

 ctc agg gcc tgg atc tca tag gt ttgcggaagg gcccaggtga agccgagaac     1200
 Leu Arg Ala Trp Ile Ser 
                 310

 ctggtctgca tgacatggaa accatgaggg gacaagttgt gtttctgttt tccgccacgg   1260

 acaagggatg agagaagtag gaagagcctg ttgtctacaa gtttagaagc aaccatcaga   1320

 ggcagggtgg tttgtctaac agaacactga ctgaggctta ggggatgtga cctctagact   1380

 gggggctgcc acttgctggc tgagcaaccc tgggaaaagt gacttcatcc cttcggtcct   1440

 aagttttctc atctgtaatg ggggaattac ctacacacct gctaaacaca cacacacaga   1500

 gtctctctct atatatacac acgtacacat aaatacaccc agcacttgca aggctagagg   1560

 gaaactggtg acactctaca gtctgactga ttcagtgttt ctggagagca ggacataaat   1620

 gtatgatgag aatgatcaag gactctacac actgggtggc ttggagagcc cactttccca   1680

 gaataatcct tgagagaaaa ggaatcatgg gagcaatggt gttgagttca cttcaagccc   1740

 aatgccggtg cagaggggaa tggcttagcg agctctacag taggtgacct ggaggaaggt   1800

 cacagccaca ctgaaaatgg gatgtgcatg aacacggagg atccatgaac tactgtaaag   1860

 tgttgacagt gtgtgcacac tgcagac                                       1887




      <210> 681
      <211> 557
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(540)

      <400> 681
 ccacgcgtcc gcacagctcc cgccaggaga aaggaacatt ctgaggggag tctacaccct     60

 gtggagctca ag    atg gtc ctg agt ggg gcg ctg tgc ttc cga atg aag     108
                  Met Val Leu Ser Gly Ala Leu Cys Phe Arg Met Lys
                    1               5                  10

 gac tcg gca ttg aag gtg ctt tat ctg cat aat aac cag ctt cta gct      156
 Asp Ser Ala Leu Lys Val Leu Tyr Leu His Asn Asn Gln Leu Leu Ala
          15                  20                  25

 gga ggg ctg cat gca ggg aag gtc att aaa ggt gaa gag atc agc gtg      204
 Gly Gly Leu His Ala Gly Lys Val Ile Lys Gly Glu Glu Ile Ser Val
      30                  35                  40

 gtc ccc aat cgg tgg ctg gat gcc agc ctg tcc ccc gtc atc ctg ggt      252
 Val Pro Asn Arg Trp Leu Asp Ala Ser Leu Ser Pro Val Ile Leu Gly
  45                  50                  55                  60

 gtc cag ggt gga agc cag tgc ctg tca tgt ggg gtg ggg cag gag ccg      300
 Val Gln Gly Gly Ser Gln Cys Leu Ser Cys Gly Val Gly Gln Glu Pro
                  65                  70                  75

 act cta aca cta gag cca gtg aac atc atg gag ctc tat ctt ggt gcc      348
 Thr Leu Thr Leu Glu Pro Val Asn Ile Met Glu Leu Tyr Leu Gly Ala
              80                  85                  90

 aag gaa tcc aag agc ttc acc ttc tac cgg cgg gac atg ggg ctc acc      396
 Lys Glu Ser Lys Ser Phe Thr Phe Tyr Arg Arg Asp Met Gly Leu Thr
          95                 100                 105

 tcc agc ttc gag tcg gct gcc tac ccg ggc tgg ttc ctg tgc acg gtg      444
 Ser Ser Phe Glu Ser Ala Ala Tyr Pro Gly Trp Phe Leu Cys Thr Val
     110                 115                 120

 cct gaa gcc gat cag cct gtc aga ctc acc cag ctt ccc gag aat ggt      492
 Pro Glu Ala Asp Gln Pro Val Arg Leu Thr Gln Leu Pro Glu Asn Gly
 125                 130                 135                 140

 ggc tgg aat gcc ccc atc aca gac ttc tac ttc cag cag tgt gac tag      540
 Gly Trp Asn Ala Pro Ile Thr Asp Phe Tyr Phe Gln Gln Cys Asp 
                 145                 150                 155

 ggcaacgtgc cccccag                                                   557




      <210> 682
      <211> 5276
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(4543)

      <400> 682
 ccaccaccta acctggtggt tacagaagga ggaacacagt cctcctgtgt tccaggtgcc     60

 aggaggtgac tgactatagc atcagtcatc actgcacacc ctacctggaa ttagtatata    120

 aagctacgcg gagcgatctc tgcccctgac cctggaaaaa tctgtctcac ccacaaag      178                                                                 
 atg tgg gct cag ctc ctt cta gga atg ttg gcc cta tca cca gcc att      226
 Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile
   1               5                  10                  15

 gca gaa gaa ctt cca aac tac ctg gtg aca tta cca gcc cgg cta aat      274
 Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn
              20                  25                  30

 ttc ccc tcc gtt cag aag gtt tgt ttg gac ctg agc cct ggg tac agt      322
 Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser
          35                  40                  45

 gat gtt aaa ttc acg gtt act ctg gag acc aag gac aag acc cag aag      370
 Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys
      50                  55                  60

 ttg cta gaa tac tct gga ctg aag aag agg cac tta cat tgt atc tcc      418
 Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser
  65                  70                  75                  80

 ttt ctt gta cca cct cct gct ggt ggc aca gaa gaa gtg gcc aca atc      466
 Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile
                  85                  90                  95

 cgg gtg tcg gga gtt gga aat aac atc agc ttt gag gag aag aaa aag      514
 Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys
             100                 105                 110

 gtt cta att cag agg cag ggg aac ggc acc ttt gta cag act gac aaa      562
 Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys
         115                 120                 125

 cct ctc tac acc cca ggg cag caa gtg tat ttc cgc att gtc acc atg      610
 Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met
     130                 135                 140

 gat agc aac ttc gtt cca gtg aat gac aag tac tcc atg gtg gaa cta      658
 Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu
 145                 150                 155                 160

 cag gat cca aat agc aac agg att gca cag tgg ctg gaa gtg gta cct      706
 Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro
                 165                 170                 175

 gag caa ggc att gta gac ctg tcc ttc caa ctg gca cca gag gca atg      754
 Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met
             180                 185                 190

 ctg ggc acc tac act gtg gca gtg gct gag ggc aag acc ttt ggt act      802
 Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr
         195                 200                 205

 ttc agt gtg gag gaa tat gtg ctg ccg aag ttt aag gtg gaa gtg gtg      850
 Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val
     210                 215                 220

 gaa ccc aag gag tta tca acg gtg cag gaa tct ttc tta gta aaa att      898
 Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile
 225                 230                 235                 240

 tgt tgt agg tac acc tat gga aag ccc atg cta ggg gca gtg cag gta      946
 Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val
                 245                 250                 255

 tct gtg tgt cag aag gca aat act tac tgg tat cga gag gtg gaa cgg      994
 Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg
             260                 265                 270

 gaa cag ctt cct gac aaa tgc agg aac ctc tct gga cag act gac aaa     1042
 Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys
         275                 280                 285

 aca gga tgt ttc tca gca cct gtg gac atg gcc acc ttt gac ctc att     1090
 Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile
     290                 295                 300

 gga tat gcg tac agc cat caa atc aat att gtg gct act gtt gtg gag     1138
 Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu
 305                 310                 315                 320

 gaa ggg aca ggt gtg gag gcc aat gcc act cag aat atc tac att tct     1186
 Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser
                 325                 330                 335

 cca caa atg gga tca atg acc ttt gaa gac acc agc aat ttt tac cat     1234
 Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His
             340                 345                 350

 cca aat ttc ccc ttc agt ggg aag ata aga gtt agg ggc cat gat gac     1282
 Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp
         355                 360                 365

 tcc ttc ctc aag aac cat cta gtg ttt ctg gtg att tat ggc aca aat     1330
 Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn
     370                 375                 380

 gga acc ttc aac cag acc ctg gtt act gat aac aat ggc cta gct ccc     1378
 Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro
 385                 390                 395                 400

 ttt acc ttg gag aca tcc ggt tgg aat ggg aca gac gtt tct ctg gag     1426
 Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu
                 405                 410                 415

 gga aag ttt caa atg gaa gac tta gta tat aat ccg gaa caa gtg cca     1474
 Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro
             420                 425                 430

 cgt tac tac caa aat gcc tac ctg cac ctg cga ccc ttc tac agc aca     1522
 Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr
         435                 440                 445

 acc cgc agc ttc ctt ggc atc cac cgg cta aac ggc ccc ttg aaa tgt     1570
 Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys
     450                 455                 460

 ggc cag ccc cag gaa gtg ctg gtg gat tat tac atc gac ccg gcc gat     1618
 Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp
 465                 470                 475                 480

 gca agc cct gac caa gag atc agc ttc tcc tac tat tta ata ggg aaa     1666
 Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys
                 485                 490                 495

 gga agt ttg gtg atg gag ggg cag aaa cac ctg aac tct aag aag aaa     1714
 Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys
             500                 505                 510

 gga ctg aaa gcc tcc ttc tct ctc tca ctg acc ttc act tcg aga ctg     1762
 Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu
         515                 520                 525

 gcc cct gat cct tcc ctg gtg atc tat gcc att ttt ccc agt gga ggt     1810
 Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly
     530                 535                 540

 gtt gta gct gac aaa att cag ttc tca gtc gag atg tgc ttt gac aat     1858
 Val Val Ala Asp Lys Ile Gln Phe Ser Val Glu Met Cys Phe Asp Asn
 545                 550                 555                 560

 cag gtt tcc ctt ggc ttc tcc ccc tcc cag cag ctt cca gga gca gaa     1906
 Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu
                 565                 570                 575

 gtg gag ctg cag ctg cag gca gct ccc gga tcc ctg tgt gcg ctc cgg     1954
 Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg
             580                 585                 590

 gcg gtg gat gag agt gtc tta ctg ctt agg cca gac aga gag ctg agc     2002
 Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser
         595                 600                 605

 aac cgc tct gtc tat ggg atg ttt cca ttc tgg tat ggt cac tac ccc     2050
 Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro
     610                 615                 620

 tat caa gtg gct gag tat gat cag tgt cca gtg tct ggc cca tgg gac     2098
 Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp
 625                 630                 635                 640

 ttt cct cag ccc ctc att gac cca atg ccc caa ggg cat tcg agc cag     2146
 Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln
                 645                 650                 655

 cgt tcc att atc tgg agg ccc tcg ttc tct gaa ggc acg gac ctt ttc     2194
 Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe
             660                 665                 670

 agc ttt ttc cgg gac gtg ggc ctg aaa ata ctg tcc aat gcc aaa atc     2242
 Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile
         675                 680                 685

 aag aag cca gta gat tgc agt cac aga tct cca gaa tac agc act gct     2290
 Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala
     690                 695                 700

 atg ggt gca ggc ggt ggt cat cca gag gct ttt gag tca tca act cct     2338
 Met Gly Ala Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro
 705                 710                 715                 720

 tta cat caa gca gag gat tct cag gtc cgc cag tac ttc cca gag acc     2386
 Leu His Gln Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr
                 725                 730                 735

 tgg ctc tgg gat ctg ttt cct att ggt aac tcg ggg aag gag gcg gtc     2434
 Trp Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val
             740                 745                 750

 cac gtc aca gtt cct gac gcc atc acc gag tgg aag gcg atg agt ttc     2482
 His Val Thr Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe
         755                 760                 765

 tgc act tcc cag tca aga ggc ttc ggg ctt tca ccc act gtt gga cta     2530
 Cys Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu
     770                 775                 780

 act gct ttc aag cca ttc ttt gtt gac ctg act ctc cct tac tca gta     2578
 Thr Ala Phe Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val
 785                 790                 795                 800

 gtc cgt ggg gaa tcc ttt cgt ctt act gcc acc atc ttc aat tac cta     2626
 Val Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu
                 805                 810                 815

 aag gat tgc atc agg gtt cag act gac ctg gct aaa tcg cat gag tac     2674
 Lys Asp Cys Ile Arg Val Gln Thr Asp Leu Ala Lys Ser His Glu Tyr
             820                 825                 830

 cag cta gaa tca tgg gca gat tct cag acc tcc agt tgt ctc tgt gct     2722
 Gln Leu Glu Ser Trp Ala Asp Ser Gln Thr Ser Ser Cys Leu Cys Ala
         835                 840                 845

 gat gaa gca aaa acc cac cac tgg aac atc aca gct gtc aaa ttg ggt     2770
 Asp Glu Ala Lys Thr His His Trp Asn Ile Thr Ala Val Lys Leu Gly
     850                 855                 860

 cac att aac ttt act att agt aca aag att ctg gac agc aat gaa cca     2818
 His Ile Asn Phe Thr Ile Ser Thr Lys Ile Leu Asp Ser Asn Glu Pro
 865                 870                 875                 880

 tgt ggg ggc cag aag ggg ttt gtt ccc caa aag ggc cga agt gac acg     2866
 Cys Gly Gly Gln Lys Gly Phe Val Pro Gln Lys Gly Arg Ser Asp Thr
                 885                 890                 895

 ctc atc aag cca gtt ctc gtc aaa cct gag gga gtc ctg gtg gag aag     2914
 Leu Ile Lys Pro Val Leu Val Lys Pro Glu Gly Val Leu Val Glu Lys
             900                 905                 910

 aca cac agc tca ttg ctg tgc cca aaa gga aag gtg gca tct gaa tct     2962
 Thr His Ser Ser Leu Leu Cys Pro Lys Gly Lys Val Ala Ser Glu Ser
         915                 920                 925

 gtc tcc ctg gag ctc cca gtg gac att gtt cct gac tcg acc aag gct     3010
 Val Ser Leu Glu Leu Pro Val Asp Ile Val Pro Asp Ser Thr Lys Ala
     930                 935                 940

 tat gtt acg gtt ctg gga gac att atg ggc aca gcc ctg cag aac ctg     3058
 Tyr Val Thr Val Leu Gly Asp Ile Met Gly Thr Ala Leu Gln Asn Leu
 945                 950                 955                 960

 gat ggt ctg gtg cag atg ccc agt ggc tgt ggc gag cag aac atg gtc     3106
 Asp Gly Leu Val Gln Met Pro Ser Gly Cys Gly Glu Gln Asn Met Val
                 965                 970                 975

 ttg ttt gct ccc atc atc tat gtc ttg cag tac ctg gag aag gca ggg     3154
 Leu Phe Ala Pro Ile Ile Tyr Val Leu Gln Tyr Leu Glu Lys Ala Gly
             980                 985                 990

 ctg ctg acg gag gag atc agg tct cgg gca gtg ggt ttc ctg gaa ata     3202
 Leu Leu Thr Glu Glu Ile Arg Ser Arg Ala Val Gly Phe Leu Glu Ile
         995                1000                1005

 ggg tac cag aag gag ctg atg tac aaa cac agc aat ggc tca tac agt     3250
 Gly Tyr Gln Lys Glu Leu Met Tyr Lys His Ser Asn Gly Ser Tyr Ser
    1010                1015                1020

 gcc ttt ggg gag cga gat gga aat gga aac aca tgg ctg aca gcg ttt     3298
 Ala Phe Gly Glu Arg Asp Gly Asn Gly Asn Thr Trp Leu Thr Ala Phe
1025                1030                1035                1040

 gtc aca aaa tgc ttt ggc caa gct cag aaa ttc atc ttc att gat ccc     3346
 Val Thr Lys Cys Phe Gly Gln Ala Gln Lys Phe Ile Phe Ile Asp Pro
                1045                1050                1055

 aag aac atc cag gat gct ctc aag tgg atg gca gga aac cag ctc ccc     3394
 Lys Asn Ile Gln Asp Ala Leu Lys Trp Met Ala Gly Asn Gln Leu Pro
            1060                1065                1070

 agt ggc tgc tat gcc aac gtg gga aat ctc ctt cac aca gct atg aag     3442
 Ser Gly Cys Tyr Ala Asn Val Gly Asn Leu Leu His Thr Ala Met Lys
        1075                1080                1085

 ggt ggt gtt gat gat gag gtc tcc ttg act gcg tat gtc aca gct gca     3490
 Gly Gly Val Asp Asp Glu Val Ser Leu Thr Ala Tyr Val Thr Ala Ala
    1090                1095                1100

 ttg ctg gag atg gga aag gat gta gat gac cca atg gtg agt cag ggt     3538
 Leu Leu Glu Met Gly Lys Asp Val Asp Asp Pro Met Val Ser Gln Gly
1105                1110                1115                1120

 cta cgg tgt ctc aag aat tcg gcc acc tcc acg acc aac ctc tac aca     3586
 Leu Arg Cys Leu Lys Asn Ser Ala Thr Ser Thr Thr Asn Leu Tyr Thr
                1125                1130                1135

 cag gcc ctg ttg gct tac att ttc tcc ctg gct ggg gaa atg gac atc     3634
 Gln Ala Leu Leu Ala Tyr Ile Phe Ser Leu Ala Gly Glu Met Asp Ile
            1140                1145                1150

 aga aac att ctc ctt aaa cag tta gat caa cag gct atc atc tca gga     3682
 Arg Asn Ile Leu Leu Lys Gln Leu Asp Gln Gln Ala Ile Ile Ser Gly
        1155                1160                1165

 gaa tcc att tac tgg agc cag aaa cct act cca tca tcg aac gcc agc     3730
 Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser Ser Asn Ala Ser
    1170                1175                1180

 cct tgg tct gag cct gcg gct gta gat gtg gaa ctc aca gca tat gca     3778
 Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu Thr Ala Tyr Ala
1185                1190                1195                1200

 ttg ttg gcc cag ctt acc aag ccc agc ctg act caa aag gag ata gcg     3826
 Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln Lys Glu Ile Ala
                1205                1210                1215

 aag gcc act agc ata gtg gct tgg ttg gcc aag caa cgc aat gca tat     3874
 Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln Arg Asn Ala Tyr
            1220                1225                1230

 ggg ggc ttc tct tct act cag gat act gta gtt gct ctc caa gct ctt     3922
 Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu Gln Ala Leu
        1235                1240                1245

 gcc aaa tat gcc act acc gcc tac gtg cca tct gag gag atc aac ctg     3970
 Ala Lys Tyr Ala Thr Thr Ala Tyr Val Pro Ser Glu Glu Ile Asn Leu
    1250                1255                1260

 gtt gta aaa tcc act gag aat ttc cag cgc aca ttc aac ata cag tca     4018
 Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe Asn Ile Gln Ser
1265                1270                1275                1280

 gtt aac aga ttg gta ttt cag cag gat acc ctg ccc aat gtc cct gga     4066
 Val Asn Arg Leu Val Phe Gln Gln Asp Thr Leu Pro Asn Val Pro Gly
                1285                1290                1295

 atg tac acg ttg gag gcc tca ggc cag ggc tgt gtc tat gtg cag acg     4114
 Met Tyr Thr Leu Glu Ala Ser Gly Gln Gly Cys Val Tyr Val Gln Thr
            1300                1305                1310

 gtg ttg aga tac aat att ctc cct ccc aca aat atg aag acc ttt agt     4162
 Val Leu Arg Tyr Asn Ile Leu Pro Pro Thr Asn Met Lys Thr Phe Ser
        1315                1320                1325

 ctt agt gtg gaa ata gga aaa gct aga tgt gag caa ccg act tca cct     4210
 Leu Ser Val Glu Ile Gly Lys Ala Arg Cys Glu Gln Pro Thr Ser Pro
    1330                1335                1340

 cga tcc ttg act ctc act att cac acc agt tat gtg ggg agc cgt agc     4258
 Arg Ser Leu Thr Leu Thr Ile His Thr Ser Tyr Val Gly Ser Arg Ser
1345                1350                1355                1360

 tct tcc aat atg gct att gtg gaa gtg aag atg cta tct ggg ttc agt     4306
 Ser Ser Asn Met Ala Ile Val Glu Val Lys Met Leu Ser Gly Phe Ser
                1365                1370                1375

 ccc atg gag ggc acc aat cag tta ctt ctc cag caa ccc ctg gtg aag     4354
 Pro Met Glu Gly Thr Asn Gln Leu Leu Leu Gln Gln Pro Leu Val Lys
            1380                1385                1390

 aag gtt gaa ttt gga act gac aca ctt aac att tac ttg gat gag ctc     4402
 Lys Val Glu Phe Gly Thr Asp Thr Leu Asn Ile Tyr Leu Asp Glu Leu
        1395                1400                1405

 att aag aac act cag act tac acc ttc acc atc agc caa agt gtg ctg     4450
 Ile Lys Asn Thr Gln Thr Tyr Thr Phe Thr Ile Ser Gln Ser Val Leu
    1410                1415                1420

 gtc acc aac ttg aaa cca gca acc atc aag gtc tat gac tac tac cta     4498
 Val Thr Asn Leu Lys Pro Ala Thr Ile Lys Val Tyr Asp Tyr Tyr Leu
1425                1430                1435                1440

 cca gat gaa cag gca aca att cag tat tct gat ccc tgt gaa tga gga     4546
 Pro Asp Glu Gln Ala Thr Ile Gln Tyr Ser Asp Pro Cys Glu 
                1445                1450

 taggagctgg aaactcaatt agtcctctgt gacatttact ggagggtgga acattcttct   4606

 gtcgcttgaa gcagaactca ttcaatcaaa taatttaatt tctctgacta gtatatgggt   4666

 aacaaatgaa tatgtctgaa cctcagctat aatactttct actacctttg caaggagatg   4726

 ggataggaac aatcactcag aggaggcgtt gcatggacag ggtcataggg ggaagaaagg   4786

 tggtttagct gttttattta gccattcagg gggctctcca gagaggagac ggtggtagag   4846

 ggtgaactag agaagataag aatgtcttcc taggccggat gcggtggctc acgcctgtaa   4906

 tcccagcact ttgggattgc gaggtgggcg gatcacttga ggtcaggagt tcaagaccag   4966

 cctggccaac atggtaaaac ccgtctctac taacaataca aagattagcc tggtgtggtg   5026

 gcacgggcct gtaatcgcag ccccttggaa ggccaaggca ggagaatcgc ctcaacactg   5086

 gaggtggagg ttgcagtgag ctgagattgt gccactgcac tccagcctgg gcaatgaggc   5146

 aagaccctgt ctcaaaaaat aataaataat aataataata atgtttttct agagtttcag   5206

 tctaagggaa aatgtgattt agggctttgg aaattggcta aaaaaataaa aatggaaagg   5266

 aaaaaaaaaa                                                          5276




      <210> 683
      <211> 985
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (332)..(727)

      <400> 683
 cagcataata tgtatcaaag tcatgcttaa acagctgtgg ggagtagagg agtatagaag     60

 aggcaacagg ttccaggatt ggcgtcttaa cacaaaatgc aactaacatg ggactttcag    120

 ttatcatttc ctttatatat ggatgggaga tgacattcct gattctgagt attgctccag    180

 tacttgccgt gacaggaatg attgaaaccg cagcaatgac tggatttgcc aacaaagata    240

 agcaagaact taagcatgct ggaaagcaac tgaagctttg gagaatatac gtactatagt    300

 gtcattaaca agggaaaaag ccttcgagca a   atg tat gaa gag atg ctt cag     352
                                      Met Tyr Glu Glu Met Leu Gln
                                        1               5

 act caa cac aga aat acc tcg aag aaa aca cag att att gga agc tgt      400
 Thr Gln His Arg Asn Thr Ser Lys Lys Thr Gln Ile Ile Gly Ser Cys
          10                  15                  20

 tat gca ttc agc cat gcc ttt ata tat ttt gcc tat gca gca ggg ttt      448
 Tyr Ala Phe Ser His Ala Phe Ile Tyr Phe Ala Tyr Ala Ala Gly Phe
      25                  30                  35

 cga ttt gga gcc tat tta att caa gct gga cga atg acc cca gag ggc      496
 Arg Phe Gly Ala Tyr Leu Ile Gln Ala Gly Arg Met Thr Pro Glu Gly
  40                  45                  50                  55

 atg ttc ata gtt ttt act gca att gca tat gga gct atg gcc atc gga      544
 Met Phe Ile Val Phe Thr Ala Ile Ala Tyr Gly Ala Met Ala Ile Gly
                  60                  65                  70

 aaa acg ctc gtt ttg gct cct gaa tat tcc aaa gcc aaa tcg ggg cgt      592
 Lys Thr Leu Val Leu Ala Pro Glu Tyr Ser Lys Ala Lys Ser Gly Arg
              75                  80                  85

 gcg cat ctg ttt gcc ttg ttg gaa aag aaa cca aat ata gac agc cgc      640
 Ala His Leu Phe Ala Leu Leu Glu Lys Lys Pro Asn Ile Asp Ser Arg
          90                  95                 100

 agt caa gaa ggg aaa aag cca gta agc aca agt gtg atc tta aat gtc      688
 Ser Gln Glu Gly Lys Lys Pro Val Ser Thr Ser Val Ile Leu Asn Val
     105                 110                 115

 caa ata aag atg gca aca gta gga act ggg ggc cac tga agatgggagg       737
 Gln Ile Lys Met Ala Thr Val Gly Thr Gly Gly His 
 120                 125                 130

 gagagagggg gcaagggctg aaaaactaac cattgggtgc tatactcagt acctgtgtga    797

 caagatcatt cataccccaa acatcagcat tacgcaatat acccagacaa caaacctgcg    857

 catatactcc tggatctaaa ataaaagttg aaaaaataaa atgtaacata aatgaaaaat    917

 aaaaataaaa aataaaaaaa aaaaaaaaaa aagataatta attaaacggc cgcaaccata    977

 ttcccttt                                                             985




      <210> 684
      <211> 850
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (45)..(449)

      <400> 684
 tcggcacgag cggcacgagg tctgagagga acccttctct gagg atg gac act tct      56
                                                  Met Asp Thr Ser
                                                    1

 cac act aca aag tcc tgt ttg ctg att ctt ctt gtg gcc cta ctg tgt      104
 His Thr Thr Lys Ser Cys Leu Leu Ile Leu Leu Val Ala Leu Leu Cys
   5                  10                  15                  20

 gca gaa aga gct cag gga ctg gag tgt tac cag tgc tat gga gtc cca      152
 Ala Glu Arg Ala Gln Gly Leu Glu Cys Tyr Gln Cys Tyr Gly Val Pro
                  25                  30                  35

 ttt gag act tct tgc cca tca att acc tgc ccc tac cct gat gga gtc      200
 Phe Glu Thr Ser Cys Pro Ser Ile Thr Cys Pro Tyr Pro Asp Gly Val
              40                  45                  50

 tgt gtt act cag gag gca gca gtt att gtg gat tct caa aca agg aaa      248
 Cys Val Thr Gln Glu Ala Ala Val Ile Val Asp Ser Gln Thr Arg Lys
          55                  60                  65

 gta aag aac aat ctt tgc tta ccc atc tgc cct cct aat att gaa agt      296
 Val Lys Asn Asn Leu Cys Leu Pro Ile Cys Pro Pro Asn Ile Glu Ser
      70                  75                  80

 atg gag atc ctg ggt act aag gtc aac gtg aag act tcc tgt tgc cag      344
 Met Glu Ile Leu Gly Thr Lys Val Asn Val Lys Thr Ser Cys Cys Gln
  85                  90                  95                 100

 gaa gac ctc tgc aat gta gca gtt ccc aat gga ggc agc acc tgg acc      392
 Glu Asp Leu Cys Asn Val Ala Val Pro Asn Gly Gly Ser Thr Trp Thr
                 105                 110                 115

 atg gca ggg gtg ctt ctg ttc agc ctg agc tca gtc ctc ctg cag acc      440
 Met Ala Gly Val Leu Leu Phe Ser Leu Ser Ser Val Leu Leu Gln Thr
             120                 125                 130

 ttg ctc tga tggtcct cccaatgacc tccacccttg tccttttatc ctcatgtgca      496
 Leu Leu 


 acaattcttc ctggagccct ctagtgatga attatgagtt atagaagctc caaggtggga    556

 gtagtgtgtg aaataccatg ttttgccttt atagcccctg ctgggtaggt aggtgctcta    616

 atcctctcta gggctttcaa gtctgtactt cctagaatgt cattttgttg tggattgctg    676

 ctcatgaccc tggaggcaca cagccagcac agtgaagagg cagaattcca aggtattatg    736

 ctatcaccat ccacacataa gtatctgggg tcctgcaatg ttcccacatg tatcctgaat    796

 gtccccctgt tgagtccaat aaaccctttg ttctcccaaa aaaaaaaaaa aaaa          850


      <210> 685
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 685
 Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu
   1               5                  10                  15    
 Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu
              20                  25                  30        
 Ser Arg Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln
          35                  40                  45            
 Leu Ala Ile Asp Thr Tyr Gln Glu Phe Ile Ser Ser Trp Gly Met Gly
      50                  55                  60                
 Ala Gly Gln Gly Trp Gln Glu Gly Val Thr Phe Pro His Trp Gly Ser
  65                  70                  75                  80
 Asn Gly Arg Arg Leu Arg Ser Ser Gly Leu Phe Ser Glu Ala Lys Met
                  85                  90                  95    
 Gln Ala Asp Glu His Arg Leu Ser Gln Val Pro Arg Arg Val Thr Val
             100                 105                 110        
 Gly Ala Gly Leu Gln His Arg Lys Gln Trp Ser Phe Leu Val Gly Gly
         115                 120                 125            
 Pro Ser Pro Arg Lys Lys Pro Ile Ser Gln Arg Asn Arg Ser Ile His
     130                 135                 140                
 Ser Cys Met Thr Pro Arg Pro Pro Ser Ala Ser Gln Thr Leu Phe Arg
 145                 150                 155                 160
 His Pro Pro Thr Trp Arg Lys Arg Ser Arg Asn Pro Thr
                 165                 170            



      <210> 686
      <211> 256
      <212> PRT
      <213> Homo sapiens


      <400> 686
 Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu
   1               5                  10                  15    
 Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu
              20                  25                  30        
 Ser Arg Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln
          35                  40                  45            
 Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Thr Lys
      50                  55                  60                
 Glu Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe
  65                  70                  75                  80
 Ser Asp Ser Ile Pro Thr Ser Ser Asn Met Glu Glu Thr Gln Gln Lys
                  85                  90                  95    
 Ser Asn Leu Glu Leu Leu His Ile Ser Leu Leu Leu Ile Glu Ser Arg
             100                 105                 110        
 Leu Glu Pro Val Arg Phe Leu Arg Ser Thr Phe Thr Asn Asn Leu Val
         115                 120                 125            
 Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu
     130                 135                 140                
 Glu Gly Ile Gln Met Leu Met Gly Val Arg Val Ala Pro Gly Val Pro
 145                 150                 155                 160
 Asn Pro Gly Ser Pro Leu Ala Ser Arg Ala Gly Gly Glu Lys His Cys
                 165                 170                 175    
 Cys Pro Leu Phe Ser Ser Gln Ala Leu Thr Gln Glu Asn Ser Pro Tyr
             180                 185                 190        
 Ser Ser Phe Pro Leu Val Asn Pro Pro Gly Leu Ser Leu His Pro Glu
         195                 200                 205            
 Gly Glu Gly Gly Lys Trp Ile Asn Glu Arg Gly Arg Glu Gln Cys Pro
     210                 215                 220                
 Ser Ala Trp Ser Leu Leu Leu Leu Leu His Phe Ala Glu Ala Gly Arg
 225                 230                 235                 240
 Arg Gln Pro Pro Asp Trp Ala Asp Pro Gln Ala Asp Leu Gln Gln Val
                 245                 250                 255    





      <210> 687
      <211> 18
      <212> PRT
      <213> Homo sapiens


      <400> 687
 Met Ala Ala Gly Arg Ser Leu Tyr His Lys Gly Thr Glu Val Phe Ile
   1               5                  10                  15    
 Pro Ala
        



      <210> 688
      <211> 256
      <212> PRT
      <213> Homo sapiens


      <400> 688
 Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu
   1               5                  10                  15    
 Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu
              20                  25                  30        
 Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln
          35                  40                  45            
 Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys
      50                  55                  60                
 Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe
  65                  70                  75                  80
 Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys
                  85                  90                  95    
 Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp
             100                 105                 110        
 Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val
         115                 120                 125            
 Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu
     130                 135                 140                
 Glu Gly Ile Gln Thr Leu Met Gly Val Arg Val Ala Pro Gly Val Thr
 145                 150                 155                 160
 Asn Pro Gly Thr Pro Leu Ala Ser Arg Ala Gly Gly Glu Lys Tyr Cys
                 165                 170                 175    
 Cys Pro Leu Phe Ser Ser Lys Ala Leu Thr Gln Glu Asn Ser Pro Tyr
             180                 185                 190        
 Ser Ser Phe Arg Leu Val Asn Pro Pro Gly Leu Ser Leu His Pro Glu
         195                 200                 205            
 Gly Glu Gly Gly Lys Trp Ile Asn Glu Arg Gly Arg Glu Gln Cys Pro
     210                 215                 220                
 Ser Ala Trp Pro Leu Leu Leu Phe Leu His Phe Ala Glu Ala Gly Arg
 225                 230                 235                 240
 Arg Gln Pro Pro Asp Trp Ala Asp Pro Gln Ala Asp Leu Gln Gln Val
                 245                 250                 255    





      <210> 689
      <211> 400
      <212> PRT
      <213> Homo sapiens


      <400> 689
 Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His
   1               5                  10                  15    
 Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp
              20                  25                  30        
 Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys
          35                  40                  45            
 Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp
      50                  55                  60                
 Leu Tyr Arg Val Arg Ser Ser Thr Ser Pro Thr Thr Asn Val Leu Leu
  65                  70                  75                  80
 Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala
                  85                  90                  95    
 Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu
             100                 105                 110        
 Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr
         115                 120                 125            
 Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe
     130                 135                 140                
 Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Val Gln
 145                 150                 155                 160
 Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu Ala Arg
                 165                 170                 175    
 Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu Gly Val
             180                 185                 190        
 Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg Lys Thr
         195                 200                 205            
 Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg Val Pro
     210                 215                 220                
 Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp Ser Asp
 225                 230                 235                 240
 Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met Ser Ile
                 245                 250                 255    
 Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu Ile Glu
             260                 265                 270        
 Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu Leu Lys
         275                 280                 285            
 Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser Tyr Glu
     290                 295                 300                
 Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser Leu Phe
 305                 310                 315                 320
 Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys Leu Thr
                 325                 330                 335    
 Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly Ala Gly
             340                 345                 350        
 Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe Pro Leu
         355                 360                 365            
 Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp Thr Asp
     370                 375                 380                
 Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg Gly Pro
 385                 390                 395                 400





      <210> 690
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 690
 Met Ala Asn Ser Val Glu Glu Ala Gln Ile Trp Met Arg Gly Leu Gln
   1               5                  10                  15    
 Leu Leu Val Asp Leu Val Thr Ser Met Asp His Gln Glu Arg Leu Asp
              20                  25                  30        
 Gln Trp Leu Ser Asp Trp Phe Gln Arg Gly Asp Lys Asn Gln Asp Gly
          35                  40                  45            
 Lys Met Ser Phe Gln Glu Val Gln Arg Leu Leu His Leu Met Asn Val
      50                  55                  60                
 Glu Met Asp Gln Glu Tyr Ala Phe Ser Leu Phe Gln Ala Ala Asp Thr
  65                  70                  75                  80
 Ser Gln Ser Gly Thr Leu Glu Gly Glu Glu Phe Val Gln Phe Tyr Lys
                  85                  90                  95    
 Ala Leu Thr Lys Arg Ala Glu Val Gln Glu Leu Phe Glu Ser Phe Ser
             100                 105                 110        
 Ala Asp Gly Gln Lys Leu Thr Leu Leu Glu Phe Leu Asp Phe Leu Gln
         115                 120                 125            
 Glu Glu Gln Lys Glu Arg Asp Cys Thr Ser Glu Leu Ala Leu Glu Leu
     130                 135                 140                
 Ile Asp Arg Tyr Glu Pro Ser Asp Ser Gly Lys Leu Arg His Val Pro
 145                 150                 155                 160
 Ser Met Asp Gly Phe Leu Ser Tyr Leu Cys Ser Lys Asp Gly Asp Ile
                 165                 170                 175    
 Phe Asn Pro Ala Cys Leu Pro Ile Tyr Gln Asp Met Thr Gln Pro Leu
             180                 185                 190        
 Asn His Tyr Phe Ile Cys Ser Ser His Asn Thr Tyr Leu Val Gly Asp
         195                 200                 205            
 Gln Leu Cys Gly Gln Ser Ser Val Glu Gly Tyr Ile Arg Cys Ser Gly
     210                 215                 220                
 Gly Arg Glu Gly Val Gln Leu Met Arg Gly Thr Met
 225                 230                 235    



      <210> 691
      <211> 672
      <212> PRT
      <213> Homo sapiens


      <400> 691
 Met Pro Gly Met Val Leu Phe Gly Arg Arg Trp Ala Ile Ala Ser Asp
   1               5                  10                  15    
 Asp Leu Val Phe Pro Gly Phe Phe Glu Leu Val Val Arg Val Leu Trp
              20                  25                  30        
 Trp Ile Gly Ile Leu Thr Leu Tyr Leu Met His Arg Gly Lys Leu Asp
          35                  40                  45            
 Cys Ala Gly Gly Ala Leu Leu Ser Ser Tyr Leu Ile Val Leu Met Ile
      50                  55                  60                
 Leu Leu Ala Val Val Ile Cys Thr Val Ser Ala Ile Met Cys Val Ser
  65                  70                  75                  80
 Met Arg Gly Thr Ile Cys Asn Pro Gly Pro Arg Lys Ser Met Ser Lys
                  85                  90                  95    
 Leu Leu Tyr Ile Arg Leu Ala Leu Phe Phe Pro Glu Met Val Trp Ala
             100                 105                 110        
 Ser Leu Gly Ala Ala Trp Val Ala Asp Gly Val Gln Cys Asp Arg Thr
         115                 120                 125            
 Val Val Asn Gly Ile Ile Ala Thr Val Val Val Ser Trp Ile Ile Ile
     130                 135                 140                
 Ala Ala Thr Val Val Ser Ile Ile Ile Val Phe Asp Pro Leu Gly Gly
 145                 150                 155                 160
 Lys Met Ala Pro Tyr Ser Ser Ala Gly Pro Ser His Leu Asp Ser His
                 165                 170                 175    
 Asp Ser Ser Gln Leu Leu Asn Gly Leu Lys Thr Ala Ala Thr Ser Val
             180                 185                 190        
 Trp Glu Thr Arg Ile Lys Leu Leu Cys Cys Cys Ile Gly Lys Asp Asp
         195                 200                 205            
 His Thr Arg Val Ala Phe Ser Ser Thr Ala Glu Leu Phe Ser Thr Tyr
     210                 215                 220                
 Phe Ser Asp Thr Asp Leu Val Pro Ser Asp Ile Ala Ala Gly Leu Ala
 225                 230                 235                 240
 Leu Leu His Gln Gln Gln Asp Asn Ile Arg Asn Asn Gln Glu Pro Ala
                 245                 250                 255    
 Gln Val Val Cys His Ala Pro Gly Ser Ser Gln Glu Ala Asp Leu Asp
             260                 265                 270        
 Ala Glu Leu Glu Asn Cys His His Tyr Met Gln Phe Ala Ala Ala Ala
         275                 280                 285            
 Tyr Gly Trp Pro Leu Tyr Ile Tyr Arg Asn Pro Leu Thr Gly Leu Cys
     290                 295                 300                
 Arg Ile Gly Gly Asp Cys Cys Arg Ser Arg Thr Thr Asp Tyr Asp Leu
 305                 310                 315                 320
 Val Gly Gly Asp Gln Leu Asn Cys His Phe Gly Ser Ile Leu His Thr
                 325                 330                 335    
 Thr Gly Leu Gln Tyr Arg Asp Phe Ile His Val Ser Phe His Asp Lys
             340                 345                 350        
 Val Tyr Glu Leu Pro Phe Leu Val Ala Leu Asp His Arg Lys Glu Ser
         355                 360                 365            
 Val Val Val Ala Val Arg Gly Thr Met Ser Leu Gln Asp Val Leu Thr
     370                 375                 380                
 Asp Leu Ser Ala Glu Ser Glu Val Leu Asp Val Glu Cys Glu Val Gln
 385                 390                 395                 400
 Asp Arg Leu Ala His Lys Gly Ile Ser Gln Ala Ala Arg Tyr Val Tyr
                 405                 410                 415    
 Gln Arg Leu Ile Asn Asp Gly Ile Leu Ser Gln Ala Phe Ser Ile Ala
             420                 425                 430        
 Pro Glu Tyr Arg Leu Val Ile Val Gly His Ser Leu Gly Gly Gly Ala
         435                 440                 445            
 Ala Ala Leu Leu Ala Thr Met Leu Arg Ala Ala Tyr Pro Gln Val Arg
     450                 455                 460                
 Cys Tyr Ala Phe Ser Pro Pro Arg Gly Leu Trp Ser Lys Ala Leu Gln
 465                 470                 475                 480
 Glu Tyr Ser Gln Ser Phe Ile Val Ser Leu Val Leu Gly Lys Asp Val
                 485                 490                 495    
 Ile Pro Arg Leu Ser Val Thr Asn Leu Glu Asp Leu Lys Arg Arg Ile
             500                 505                 510        
 Leu Arg Val Val Ala His Cys Asn Lys Pro Lys Tyr Lys Ile Leu Leu
         515                 520                 525            
 His Gly Leu Trp Tyr Glu Leu Phe Gly Gly Asn Pro Asn Asn Leu Pro
     530                 535                 540                
 Thr Glu Leu Asp Gly Gly Asp Gln Glu Val Leu Thr Gln Pro Leu Leu
 545                 550                 555                 560
 Gly Glu Gln Ser Leu Leu Thr Arg Trp Ser Pro Ala Tyr Ser Phe Ser
                 565                 570                 575    
 Ser Asp Ser Pro Leu Asp Ser Ser Pro Lys Tyr Pro Pro Leu Tyr Pro
             580                 585                 590        
 Pro Gly Arg Ile Ile His Leu Gln Glu Glu Gly Ala Ser Gly Arg Phe
         595                 600                 605            
 Gly Cys Cys Ser Ala Ala His Tyr Ser Ala Lys Trp Ser His Glu Ala
     610                 615                 620                
 Glu Phe Ser Lys Ile Leu Ile Gly Pro Lys Met Leu Thr Asp His Met
 625                 630                 635                 640
 Pro Asp Ile Leu Met Arg Ala Leu Asp Ser Val Val Ser Asp Arg Ala
                 645                 650                 655    
 Ala Cys Val Ser Cys Pro Ala Gln Gly Val Ser Ser Val Asp Val Ala
             660                 665                 670        





      <210> 692
      <211> 739
      <212> PRT
      <213> Homo sapiens


      <400> 692
 Met Gly Ala Val Pro Cys Arg Arg Ala Leu Leu Leu Cys Asn Gly Met
   1               5                  10                  15    
 Arg Tyr Lys Leu Leu Gln Glu Gly Asp Ile Gln Val Cys Val Ile Arg
              20                  25                  30        
 His Pro Arg Thr Phe Leu Ser Lys Ile Leu Thr Ser Lys Phe Leu Arg
          35                  40                  45            
 Arg Trp Glu Pro His His Leu Thr Leu Ala Asp Asn Ser Leu Ala Ser
      50                  55                  60                
 Ala Thr Pro Thr Gly Tyr Met Glu Asn Ser Val Ser Tyr Ser Ala Ile
  65                  70                  75                  80
 Glu Asp Val Gln Leu Leu Ser Trp Glu Asn Ala Pro Lys Tyr Cys Leu
                  85                  90                  95    
 Gln Leu Thr Ile Pro Gly Gly Thr Val Leu Leu Gln Ala Ala Asn Ser
             100                 105                 110        
 Tyr Leu Arg Asp Gln Trp Phe His Ser Leu Gln Trp Lys Lys Lys Ile
         115                 120                 125            
 Tyr Lys Tyr Lys Lys Val Leu Ser Asn Pro Ser Arg Trp Glu Val Val
     130                 135                 140                
 Leu Lys Glu Ile Arg Thr Leu Val Asp Met Ala Leu Thr Ser Pro Leu
 145                 150                 155                 160
 Gln Asp Asp Ser Ile Asn Gln Ala Pro Leu Glu Ile Val Ser Lys Leu
                 165                 170                 175    
 Leu Ser Glu Asn Thr Asn Leu Thr Thr Gln Glu His Glu Asn Ile Ile
             180                 185                 190        
 Val Ala Ile Ala Pro Leu Leu Glu Asn Asn His Pro Pro Pro Asp Leu
         195                 200                 205            
 Cys Glu Phe Phe Cys Lys His Cys Arg Glu Arg Pro Arg Ser Met Val
     210                 215                 220                
 Val Ile Glu Val Phe Thr Pro Val Val Gln Arg Ile Leu Lys His Asn
 225                 230                 235                 240
 Met Asp Phe Gly Lys Cys Pro Arg Leu Arg Leu Phe Thr Gln Glu Tyr
                 245                 250                 255    
 Ile Leu Ala Leu Asn Glu Leu Asn Ala Gly Met Glu Val Val Lys Lys
             260                 265                 270        
 Phe Ile Gln Ser Met His Gly Pro Thr Gly His Cys Pro His Pro Arg
         275                 280                 285            
 Val Leu Pro Asn Leu Val Ala Val Cys Leu Ala Ala Ile Tyr Ser Cys
     290                 295                 300                
 Tyr Glu Glu Phe Ile Asn Ser Arg Asp Asn Ser Pro Ser Leu Lys Glu
 305                 310                 315                 320
 Ile Arg Asn Gly Cys Gln Gln Pro Cys Asp Arg Lys Pro Thr Leu Pro
                 325                 330                 335    
 Leu Arg Leu Leu His Pro Ser Pro Asp Leu Val Ser Gln Glu Ala Thr
             340                 345                 350        
 Leu Ser Glu Ala Arg Leu Lys Ser Val Val Val Ala Ser Ser Glu Ile
         355                 360                 365            
 His Val Glu Val Glu Arg Thr Ser Thr Ala Lys Pro Ala Leu Thr Ala
     370                 375                 380                
 Ser Ala Gly Asn Asp Ser Glu Pro Asn Leu Ile Asp Cys Leu Met Val
 385                 390                 395                 400
 Ser Pro Ala Cys Ser Thr Met Ser Ile Glu Leu Gly Pro Gln Ala Asp
                 405                 410                 415    
 Arg Thr Leu Gly Cys Tyr Val Glu Ile Leu Lys Leu Leu Ser Asp Tyr
             420                 425                 430        
 Asp Asp Trp Arg Pro Ser Leu Ala Ser Leu Leu Gln Pro Ile Pro Phe
         435                 440                 445            
 Pro Lys Glu Ala Leu Ala His Glu Lys Phe Thr Lys Glu Leu Lys Tyr
     450                 455                 460                
 Val Ile Gln Arg Phe Ala Glu Asp Pro Arg Gln Glu Val His Ser Cys
 465                 470                 475                 480
 Leu Leu Ser Val Arg Ala Gly Lys Asp Gly Trp Phe Gln Leu Tyr Ser
                 485                 490                 495    
 Pro Gly Gly Val Ala Cys Asp Asp Asp Gly Glu Leu Phe Ala Ser Met
             500                 505                 510        
 Val His Ile Leu Met Gly Ser Cys Tyr Lys Thr Lys Lys Phe Leu Leu
         515                 520                 525            
 Ser Leu Ala Glu Asn Lys Leu Gly Pro Cys Met Leu Leu Ala Leu Arg
     530                 535                 540                
 Gly Asn Gln Thr Met Val Glu Ile Leu Cys Leu Met Leu Glu Tyr Asn
 545                 550                 555                 560
 Ile Ile Asp Asn Asn Asp Thr Gln Leu Gln Ile Ile Ser Thr Leu Glu
                 565                 570                 575    
 Ser Thr Asp Val Gly Lys Arg Met Tyr Glu Gln Leu Cys Asp Arg Gln
             580                 585                 590        
 Arg Glu Leu Lys Glu Leu Gln Arg Lys Gly Gly Pro Thr Arg Leu Thr
         595                 600                 605            
 Leu Pro Ser Lys Ser Thr Asp Ala Asp Leu Ala Arg Leu Leu Ser Ser
     610                 615                 620                
 Gly Ser Phe Gly Asn Leu Glu Asn Leu Ser Leu Ala Phe Thr Asn Val
 625                 630                 635                 640
 Thr Ser Ala Cys Ala Glu His Leu Ile Lys Leu Pro Ser Leu Lys Gln
                 645                 650                 655    
 Leu Asn Leu Trp Ser Thr Gln Phe Gly Asp Ala Gly Leu Arg Leu Leu
             660                 665                 670        
 Ser Glu His Leu Thr Met Leu Gln Val Leu Asn Leu Cys Glu Thr Pro
         675                 680                 685            
 Val Thr Asp Ala Gly Leu Leu Ala Leu Ser Ser Met Lys Ser Leu Cys
     690                 695                 700                
 Ser Leu Asn Met Asn Ser Thr Lys Leu Ser Ala Asp Thr Tyr Glu Asp
 705                 710                 715                 720
 Leu Lys Ala Lys Leu Pro Asn Leu Lys Glu Val Asp Val Arg Tyr Thr
                 725                 730                 735    
 Glu Ala Trp
            



      <210> 693
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 693
 Met Glu Asn Phe Gly Trp Glu Asn Tyr Met Trp Glu Asp Ile Phe Ser
   1               5                  10                  15    
 Gly Asp Phe Ser Asn Tyr Ser Phe Ser Tyr Asp Pro Thr Pro Phe Leu
              20                  25                  30        
 Leu Asp Ser Ala Pro Cys Trp Pro Glu Ser Leu Glu Ile Asn Tyr Val
          35                  40                  45            
 Leu Ile Ile Ile Tyr Ala Leu Met Phe Leu Leu Asn Val Met
      50                  55                  60        



      <210> 694
      <211> 484
      <212> PRT
      <213> Homo sapiens


      <400> 694
 Met Lys Lys Gly Ile Arg Tyr Glu Thr Ser Arg Lys Thr Ser Tyr Ile
   1               5                  10                  15    
 Phe Gln Gln Pro Gln His Gly Pro Trp Gln Thr Arg Met Arg Lys Ile
              20                  25                  30        
 Ser Asn His Gly Ser Leu Arg Val Ala Lys Val Ala Tyr Pro Leu Gly
          35                  40                  45            
 Leu Cys Val Gly Val Phe Ile Tyr Val Ala Tyr Ile Lys Trp His Arg
      50                  55                  60                
 Ala Thr Ala Thr Gln Ala Phe Phe Ser Ile Thr Arg Ala Ala Pro Gly
  65                  70                  75                  80
 Ala Arg Trp Gly Gln Gln Ala His Ser Pro Leu Gly Thr Ala Ala Asp
                  85                  90                  95    
 Gly His Glu Val Phe Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly
             100                 105                 110        
 Thr Arg Val His Val Phe Gln Phe Thr Arg Pro Pro Arg Glu Thr Pro
         115                 120                 125            
 Thr Leu Thr His Glu Thr Phe Lys Ala Val Lys Pro Gly Leu Ser Ala
     130                 135                 140                
 Tyr Ala Asp Asp Val Glu Lys Ser Ala Gln Gly Ile Arg Glu Leu Leu
 145                 150                 155                 160
 Asp Val Ala Lys Gln Asp Ile Pro Phe Asp Phe Trp Lys Ala Thr Pro
                 165                 170                 175    
 Leu Val Leu Lys Ala Thr Ala Gly Leu Arg Leu Leu Pro Gly Glu Lys
             180                 185                 190        
 Ala Gln Lys Leu Leu Gln Lys Val Lys Glu Val Phe Lys Ala Ser Pro
         195                 200                 205            
 Phe Leu Val Gly Asp Asp Cys Val Ser Ile Met Asn Gly Thr Asp Glu
     210                 215                 220                
 Gly Val Ser Ala Trp Ile Thr Ile Asn Phe Leu Thr Gly Ser Leu Lys
 225                 230                 235                 240
 Thr Pro Gly Gly Ser Ser Val Gly Met Leu Asp Leu Gly Gly Gly Ser
                 245                 250                 255    
 Thr Gln Ile Ala Phe Leu Pro Arg Val Glu Gly Thr Leu Gln Ala Ser
             260                 265                 270        
 Pro Pro Gly Tyr Leu Thr Ala Leu Arg Met Phe Asn Arg Thr Tyr Lys
         275                 280                 285            
 Leu Tyr Ser Tyr Ser Tyr Leu Gly Leu Gly Leu Met Ser Ala Arg Leu
     290                 295                 300                
 Ala Ile Leu Gly Gly Val Glu Gly Gln Pro Ala Lys Asp Gly Lys Glu
 305                 310                 315                 320
 Leu Val Ser Pro Cys Leu Ser Pro Ser Phe Lys Gly Glu Trp Glu His
                 325                 330                 335    
 Ala Glu Val Thr Tyr Arg Val Ser Gly Gln Lys Ala Ala Ala Ser Leu
             340                 345                 350        
 His Glu Leu Cys Ala Ala Arg Val Ser Glu Val Leu Gln Asn Arg Val
         355                 360                 365            
 His Arg Thr Glu Glu Val Lys His Val Asp Phe Tyr Ala Phe Ser Tyr
     370                 375                 380                
 Tyr Tyr Asp Leu Ala Ala Gly Val Gly Leu Ile Asp Ala Glu Lys Gly
 385                 390                 395                 400
 Gly Ser Leu Val Val Gly Asp Phe Glu Ile Ala Ala Lys Tyr Val Cys
                 405                 410                 415    
 Arg Thr Leu Glu Thr Gln Pro Gln Ser Ser Pro Phe Ser Cys Met Asp
             420                 425                 430        
 Leu Thr Tyr Val Ser Leu Leu Leu Gln Glu Phe Gly Phe Pro Arg Ser
         435                 440                 445            
 Lys Val Leu Lys Leu Thr Arg Lys Ile Asp Asn Val Glu Thr Ser Trp
     450                 455                 460                
 Ala Leu Gly Ala Ile Phe His Tyr Ile Asp Ser Leu Asn Arg Gln Lys
 465                 470                 475                 480
 Ser Pro Ala Ser
                



      <210> 695
      <211> 363
      <212> PRT
      <213> Homo sapiens


      <400> 695
 Met Gly Pro Gly Glu Ala Leu Leu Ala Gly Leu Leu Val Met Val Leu
   1               5                  10                  15    
 Ala Val Ala Leu Leu Ser Asn Ala Leu Val Leu Leu Cys Cys Ala Tyr
              20                  25                  30        
 Ser Ala Glu Leu Arg Thr Arg Ala Ser Gly Val Leu Leu Val Asn Leu
          35                  40                  45            
 Ser Leu Gly His Leu Leu Leu Ala Ala Leu Asp Met Pro Phe Thr Leu
      50                  55                  60                
 Leu Gly Val Met Arg Gly Arg Thr Pro Ser Ala Pro Gly Ala Cys Gln
  65                  70                  75                  80
 Val Ile Gly Phe Leu Asp Thr Phe Leu Ala Ser Asn Ala Ala Leu Ser
                  85                  90                  95    
 Val Ala Ala Leu Ser Ala Asp Gln Trp Leu Ala Val Gly Phe Pro Leu
             100                 105                 110        
 Arg Tyr Ala Gly Arg Leu Arg Pro Arg Tyr Ala Gly Leu Leu Leu Gly
         115                 120                 125            
 Cys Ala Trp Gly Gln Ser Leu Ala Phe Ser Gly Ala Ala Leu Gly Cys
     130                 135                 140                
 Ser Trp Leu Gly Tyr Ser Ser Ala Phe Ala Ser Cys Ser Leu Arg Leu
 145                 150                 155                 160
 Pro Pro Glu Pro Glu Arg Pro Arg Phe Ala Ala Phe Thr Ala Thr Leu
                 165                 170                 175    
 His Ala Val Gly Phe Val Leu Pro Leu Ala Val Leu Cys Leu Thr Ser
             180                 185                 190        
 Leu Gln Val His Arg Val Ala Arg Arg His Cys Gln Arg Met Asp Thr
         195                 200                 205            
 Val Thr Met Lys Ala Leu Ala Leu Leu Ala Asp Leu His Pro Ser Val
     210                 215                 220                
 Arg Gln Arg Cys Leu Ile Gln Gln Lys Arg Arg Arg His Arg Ala Thr
 225                 230                 235                 240
 Arg Lys Ile Gly Ile Ala Ile Ala Thr Phe Leu Ile Cys Phe Ala Pro
                 245                 250                 255    
 Tyr Val Met Thr Arg Leu Ala Glu Leu Val Pro Phe Val Thr Val Asn
             260                 265                 270        
 Ala Gln Trp Gly Ile Leu Ser Lys Cys Leu Thr Tyr Ser Lys Ala Val
         275                 280                 285            
 Ala Asp Pro Phe Thr Tyr Ser Leu Leu Arg Arg Pro Phe Arg Gln Val
     290                 295                 300                
 Leu Ala Gly Met Val His Arg Leu Leu Lys Arg Thr Pro Arg Pro Ala
 305                 310                 315                 320
 Ser Thr His Asp Ser Ser Leu Asp Val Ala Gly Met Val His Gln Leu
                 325                 330                 335    
 Leu Lys Arg Thr Pro Arg Pro Ala Ser Thr His Asn Gly Ser Val Asp
             340                 345                 350        
 Thr Glu Asn Asp Ser Cys Leu Gln Gln Thr His
         355                 360            



      <210> 696
      <211> 314
      <212> PRT
      <213> Homo sapiens


      <400> 696
 Met Gln Ala Lys Tyr Ser Ser Thr Met Asp Met Leu Asp Asp Asp Gly
   1               5                  10                  15    
 Asp Thr Thr Met Ser Leu His Ser Gln Ala Ser Ala Thr Thr Arg His
              20                  25                  30        
 Pro Glu Pro Arg Arg Thr Glu His Arg Ala Pro Ser Ser Thr Trp Arg
          35                  40                  45            
 Pro Val Ala Leu Thr Leu Leu Thr Leu Cys Leu Val Leu Leu Ile Gly
      50                  55                  60                
 Leu Ala Ala Leu Gly Leu Leu Phe Phe Gln Tyr Tyr Gln Leu Ser Asn
  65                  70                  75                  80
 Thr Gly Gln Asp Thr Ile Ser Gln Met Glu Glu Arg Leu Gly Asn Thr
                  85                  90                  95    
 Ser Gln Glu Leu Gln Ser Leu Gln Val Gln Asn Ile Lys Leu Ala Gly
             100                 105                 110        
 Ser Leu Gln His Val Ala Glu Lys Leu Cys Arg Glu Leu Tyr Asn Lys
         115                 120                 125            
 Ala Gly Gly Tyr Thr Arg Asn Met Val Pro Ala Ser Ala Ser Ser Glu
     130                 135                 140                
 Ser Leu Arg Gln Leu Pro His Met Gly Glu Ser Ala Ala Ala His Arg
 145                 150                 155                 160
 Cys Ser Pro Cys Thr Glu Gln Trp Lys Trp His Gly Asp Asn Cys Tyr
                 165                 170                 175    
 Gln Phe Tyr Lys Asp Ser Lys Ser Trp Glu Asp Cys Lys Tyr Phe Cys
             180                 185                 190        
 Leu Ser Glu Asn Ser Thr Met Leu Lys Ile Asn Lys Gln Glu Asp Leu
         195                 200                 205            
 Glu Phe Ala Ala Ser Gln Ser Tyr Ser Glu Phe Phe Tyr Ser Tyr Trp
     210                 215                 220                
 Thr Gly Leu Leu Arg Pro Asp Ser Gly Lys Ala Trp Leu Trp Met Asp
 225                 230                 235                 240
 Gly Thr Pro Phe Thr Ser Glu Leu Phe His Ile Ile Ile Asp Val Thr
                 245                 250                 255    
 Ser Pro Arg Ser Arg Asp Cys Val Ala Ile Leu Asn Gly Met Ile Phe
             260                 265                 270        
 Ser Lys Asp Cys Lys Glu Leu Lys Arg Cys Val Cys Glu Arg Arg Ala
         275                 280                 285            
 Gly Met Val Lys Pro Glu Ser Leu His Val Pro Pro Glu Thr Leu Gly
     290                 295                 300                
 Glu Gly Asp Met His His His His His His
 305                 310                



      <210> 697
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 697
 Met Asp Ile Tyr Met Arg Ser Ser Phe Leu Tyr Ala Ile Pro Ala Val
   1               5                  10                  15    
 Phe Phe Phe Leu Thr Gly Pro Cys Leu Arg Ile Asn Lys Ser Val Met
              20                  25                  30        
 Ser Glu Thr Lys Val Tyr Ser Ser Val Cys Arg Cys Val Ala Pro Pro
          35                  40                  45            
 Phe Ser Pro Ala Ala Pro His Ile Gln Ser Arg Ser
      50                  55                  60



      <210> 698
      <211> 405
      <212> PRT
      <213> Homo sapiens


      <400> 698
 Met Ala Thr Ser Trp Gly Thr Val Phe Phe Met Leu Val Val Ser Cys
   1               5                  10                  15    
 Val Cys Ser Ala Val Ser His Arg Asn Gln Gln Thr Trp Phe Glu Gly
              20                  25                  30        
 Ile Phe Leu Ser Ser Met Cys Pro Ile Asn Val Ser Ala Ser Thr Leu
          35                  40                  45            
 Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly Thr Arg Ile His Val
      50                  55                  60                
 Tyr Thr Phe Val Gln Lys Met Pro Gly Gln Leu Pro Ile Leu Glu Gly
  65                  70                  75                  80
 Glu Val Phe Asp Ser Val Lys Pro Gly Leu Ser Ala Phe Val Asp Gln
                  85                  90                  95    
 Pro Lys Gln Gly Ala Glu Thr Val Gln Gly Leu Leu Glu Val Ala Lys
             100                 105                 110        
 Asp Ser Ile Pro Arg Ser His Trp Lys Lys Thr Pro Val Val Leu Lys
         115                 120                 125            
 Ala Thr Ala Gly Leu Arg Leu Leu Pro Glu His Lys Ala Lys Ala Leu
     130                 135                 140                
 Leu Phe Glu Val Lys Glu Ile Phe Arg Lys Ser Pro Phe Leu Val Pro
 145                 150                 155                 160
 Lys Gly Ser Val Ser Ile Met Asp Gly Ser Asp Glu Gly Ile Leu Ala
                 165                 170                 175    
 Trp Val Thr Val Asn Phe Leu Thr Gly Gln Leu His Gly His Arg Gln
             180                 185                 190        
 Glu Thr Val Gly Thr Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Thr
         195                 200                 205            
 Phe Leu Pro Gln Phe Glu Lys Thr Leu Glu Gln Thr Pro Arg Gly Tyr
     210                 215                 220                
 Leu Thr Ser Phe Glu Met Phe Asn Ser Thr Tyr Lys Leu Tyr Thr His
 225                 230                 235                 240
 Ser Tyr Leu Gly Phe Gly Leu Lys Ala Ala Arg Leu Ala Thr Leu Gly
                 245                 250                 255    
 Ala Leu Glu Thr Glu Gly Thr Asp Gly His Thr Phe Arg Ser Ala Cys
             260                 265                 270        
 Leu Pro Arg Trp Leu Glu Ala Glu Trp Ile Phe Gly Gly Val Lys Tyr
         275                 280                 285            
 Gln Tyr Gly Gly Asn Gln Glu Gly Glu Val Gly Phe Glu Pro Cys Tyr
     290                 295                 300                
 Ala Glu Val Leu Arg Val Val Arg Gly Lys Leu His Gln Pro Glu Glu
 305                 310                 315                 320
 Val Gln Arg Gly Ser Phe Tyr Ala Phe Ser Tyr Tyr Tyr Asp Arg Ala
                 325                 330                 335    
 Val Asp Thr Asp Met Ile Asp Tyr Glu Lys Gly Gly Ile Leu Lys Val
             340                 345                 350        
 Glu Asp Phe Glu Arg Lys Ala Arg Glu Val Cys Asp Asn Leu Glu Asn
         355                 360                 365            
 Phe Thr Ser Gly Ser Pro Phe Leu Cys Met Asp Leu Ser Tyr Ile Thr
     370                 375                 380                
 Ala Leu Leu Lys Asp Gly Phe Gly Phe Ala Asp Ser Thr Val Leu Gln
 385                 390                 395                 400
 Ala Ala Val Leu Arg
                 405



      <210> 699
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 699
 Met Asn Thr Ile Ala Trp Glu Ser Gly Glu Arg Glu Glu Thr Arg Asp
   1               5                  10                  15    
 Leu Arg Glu Pro Ala Pro Ala Pro Ser Gly Ser Val Pro Ser Arg Pro
              20                  25                  30        
 Gly Trp Val Gly Leu Pro Arg Val Gly Arg Gly Gly Met Leu Leu Pro
          35                  40                  45            
 Gly Gly Ala Ala Val Ala Asp Leu Gln Glu Glu Val Leu Gly Phe Gly
      50                  55                  60                
 Trp Gly Thr Gly Ala Val Asn Gly Glu Gln Arg Arg Gly Ala Val Gly
  65                  70                  75                  80
 Lys His Gly Asp Lys Arg Gly Lys Glu Gly Gly Ser Gly Lys Pro Lys
                  85                  90                  95    
 Ala Tyr Gly Thr Ala Ile Thr Arg Arg Asn Pro Ile Gln Val Leu Thr
             100                 105                 110        
 Ser Pro Asp Pro Ala
         115        



      <210> 700
      <211> 584
      <212> PRT
      <213> Homo sapiens


      <400> 700
 Met Gly Gly Arg Glu Leu Thr Ile Gly Glu Ile Asp Trp Lys Arg Pro
   1               5                  10                  15    
 Trp Ala Leu Ala Ala Arg Gly Val Ala Pro Pro Pro Gly Phe Leu Pro
              20                  25                  30        
 Ala His Phe Pro Pro Pro Gly Leu Gly Arg Gly Val Gln Glu Ala Leu
          35                  40                  45            
 Gly Lys Ala Ala Val Ala Gly Ala Gly Gly Ala Gln Ala Gln Ser Gly
      50                  55                  60                
 Gly Pro Gly Val Arg Lys Val Ala Pro Ala Gly Arg Leu Arg Asp Ala
  65                  70                  75                  80
 Ala Gly Arg Gln Leu Arg Arg Arg Trp Arg Pro Gly Arg Ala Gly Arg
                  85                  90                  95    
 Arg Leu Arg Thr Glu Gly Gly Thr Arg Pro Gly Trp Leu Ala Pro Gly
             100                 105                 110        
 Gly Gly Trp Ala Gly Ala Ala Val Ala Ala Ala Ala Ala Ala Gly Gly
         115                 120                 125            
 Gly Trp Ser Cys Ala Ala Ala Ala Ala Gly Pro Ala Gly Gly Gly Ala
     130                 135                 140                
 Leu Thr Ala Gly Gly Ala Ala Ala Ala Ala Gly Arg Ala Ala Gly Gly
 145                 150                 155                 160
 Glu Arg Gly Lys Met Ala Glu Leu Gly Lys Lys Tyr Cys Val Tyr Cys
                 165                 170                 175    
 Leu Ala Glu Val Ser Pro Leu Arg Phe Arg Cys Thr Glu Cys Gln Asp
             180                 185                 190        
 Ile Glu Leu Cys Pro Glu Cys Phe Ser Ala Gly Ala Glu Ile Gly His
         195                 200                 205            
 His Arg Arg Tyr His Gly Tyr Gln Leu Val Asp Gly Gly Arg Phe Thr
     210                 215                 220                
 Leu Trp Gly Pro Glu Ala Glu Gly Gly Trp Thr Ser Arg Glu Glu Gln
 225                 230                 235                 240
 Leu Leu Leu Asp Ala Ile Glu Gln Phe Gly Phe Gly Asn Trp Glu Asp
                 245                 250                 255    
 Met Ala Ala His Val Gly Ala Ser Arg Thr Pro Gln Glu Val Met Glu
             260                 265                 270        
 His Tyr Val Ser Met Tyr Ile His Gly Asn Leu Gly Lys Ala Cys Ile
         275                 280                 285            
 Pro Asp Thr Ile Pro Asn Arg Val Thr Asp His Thr Cys Pro Ser Gly
     290                 295                 300                
 Gly Pro Leu Ser Pro Ser Leu Thr Thr Pro Leu Pro Pro Leu Asp Ile
 305                 310                 315                 320
 Ser Val Ala Glu Gln Gln Gln Leu Gly Tyr Met Pro Leu Arg Asp Asp
                 325                 330                 335    
 Tyr Glu Ile Glu Tyr Asp Gln Asp Ala Glu Thr Leu Ile Ser Gly Leu
             340                 345                 350        
 Ser Val Asn Tyr Asp Asp Asp Asp Val Glu Ile Glu Leu Lys Arg Ala
         355                 360                 365            
 His Val Asp Met Tyr Val Arg Lys Leu Lys Glu Arg Gln Arg Arg Lys
     370                 375                 380                
 Asn Ile Ala Arg Asp Tyr Asn Leu Val Pro Ala Phe Leu Gly Lys Asp
 385                 390                 395                 400
 Lys Lys Glu Lys Glu Lys Ala Leu Lys Arg Lys Ile Thr Lys Glu Glu
                 405                 410                 415    
 Lys Glu Leu Arg Leu Lys Leu Arg Pro Leu Tyr Gln Phe Met Ser Cys
             420                 425                 430        
 Lys Glu Phe Asp Asp Leu Phe Glu Asn Met His Lys Glu Lys Met Leu
         435                 440                 445            
 Arg Ala Lys Ile Arg Glu Leu Gln Arg Tyr Arg Arg Asn Gly Ile Thr
     450                 455                 460                
 Lys Met Glu Glu Ser Ala Glu Tyr Glu Ala Ala Arg His Lys Arg Glu
 465                 470                 475                 480
 Lys Arg Lys Glu Asn Lys Asn Leu Ala Gly Ser Lys Arg Gly Lys Glu
                 485                 490                 495    
 Asp Gly Lys Asp Ser Glu Phe Ala Ala Ile Glu Asn Leu Pro Gly Phe
             500                 505                 510        
 Glu Leu Leu Ser Asp Arg Glu Lys Val Leu Cys Ser Ser Leu Asn Leu
         515                 520                 525            
 Ser Pro Ala Arg Tyr Val Thr Val Lys Thr Ile Ile Ile Lys Asp His
     530                 535                 540                
 Leu Gln Lys Arg Gln Gly Ile Pro Ser Lys Ser Arg Leu Pro Ser Tyr
 545                 550                 555                 560
 Leu Asp Lys Val Leu Lys Lys Arg Ile Leu Asn Phe Leu Thr Glu Ser
                 565                 570                 575    
 Gly Trp Ile Ser Arg Asp Ala Ser
             580                



      <210> 701
      <211> 1060
      <212> PRT
      <213> Homo sapiens


      <400> 701
 Met Ser Pro Ala Ala Ser Leu Pro Ala Gln Pro Ser Pro Ala Leu Pro
   1               5                  10                  15    
 Gln Ser Ser His Ala Ser Ser Thr Ser Val Phe Ser Ser Pro Gly Ser
              20                  25                  30        
 Gly Pro Gly Thr Ser Gly Asp Cys Leu Gly Arg Arg Arg Asp His Gly
          35                  40                  45            
 Arg Glu Val Lys Arg Val Trp Trp Pro Leu Gly Leu Pro Pro His Leu
      50                  55                  60                
 Gly His Leu Ala Thr Ala Arg Ser Pro Val Leu Glu Gly Lys Glu Leu
  65                  70                  75                  80
 Arg Asp Arg Val Glu Glu Arg Ala Pro Glu Gly Met Asp Leu Leu Leu
                  85                  90                  95    
 Phe Ser Val Val Gln Ala Leu Ala Thr Tyr Thr His Pro Arg Met Cys
             100                 105                 110        
 Val Ser Leu Tyr Val Asn Pro Ser Val Pro Thr Tyr Thr Tyr Pro Thr
         115                 120                 125            
 Val Leu Met Tyr Thr Tyr Pro Ser Val Leu Met Tyr Thr Tyr Pro Ser
     130                 135                 140                
 Val Pro Met Phe Met Tyr Pro Cys Val Tyr Val Pro Glu Cys Val Tyr
 145                 150                 155                 160
 Val Pro Ala Ser Val Gly Ser Glu Lys Leu Phe Ala Pro Gly Thr Asp
                 165                 170                 175    
 Lys Gly Pro Ala Asn Ala Gly Lys Asp Gly Pro Tyr Cys Pro Ser Ala
             180                 185                 190        
 Gly Met Ala Phe Thr Cys Leu Gln Val Gly Ser Leu Phe Thr Ser Glu
         195                 200                 205            
 His His Ser Lys Ala Gly Ala Asp Gly Val Val Ser Glu Gly Ala Cys
     210                 215                 220                
 Met Gly Arg Ala Pro Pro Leu Cys Gly Arg Trp Val Val Ala Ala Val
 225                 230                 235                 240
 Glu Gly Leu Ala Pro Gly Pro Ala Leu Glu Lys Ser Glu Ala Lys Ala
                 245                 250                 255    
 Gly Pro Val Pro Lys Val Ser Gly Leu Glu Arg Ser Arg Glu Leu Ser
             260                 265                 270        
 Ala Glu Ser Phe Leu Pro Thr Ala Ser Pro Ala Pro His Ala Ala Pro
         275                 280                 285            
 Cys Pro Gly Pro Pro Pro Gly Ser Arg Ala Asn Pro Leu Val Lys Lys
     290                 295                 300                
 Glu Pro Pro Ala Pro His Arg His Thr Pro Gln Pro Pro Pro Pro Gln
 305                 310                 315                 320
 Pro Arg Gly Leu Leu Pro Thr His Val Pro Ala Ser Leu Gly Ala Phe
                 325                 330                 335    
 Ala Gly His Ser Gln Ala Ala Ala Asn Gly Leu His Gly Leu Ser Arg
             340                 345                 350        
 Ser Ser Ser Ala Pro Leu Gly Leu Gly Lys His Val Ser Leu Ser Pro
         355                 360                 365            
 His Gly Pro Gly Pro His Leu Ser Thr Ser His Leu Ala Leu Arg Ser
     370                 375                 380                
 Gln Ala Gln His Gln Leu His Ala Ala Met Phe Ala Ala Pro Pro Thr
 385                 390                 395                 400
 Leu Pro Pro Pro Pro Ala Leu Pro Ala Ser Ser Leu Val Leu Pro Gly
                 405                 410                 415    
 His Pro Ala Asp His Glu Leu Leu Arg Gln Glu Leu Asn Thr Arg Phe
             420                 425                 430        
 Leu Val Gln Ser Ala Glu Arg Pro Gly Ala Ser Leu Gly Pro Gly Ala
         435                 440                 445            
 Leu Leu Arg Ala Glu Phe His Gln His Gln His Thr His Gln His Thr
     450                 455                 460                
 His Gln His Thr His Gln His Gln His Thr Phe Ala Pro Phe Pro Ala
 465                 470                 475                 480
 Gly Leu Pro Pro Thr Pro Pro Ala Ala Pro Pro Pro Phe Asp Lys Tyr
                 485                 490                 495    
 Ala Pro Lys Leu Asp Ser Pro Tyr Phe Arg His Ser Ser Val Ser Phe
             500                 505                 510        
 Phe Pro Ser Phe Pro Pro Ala Ile Pro Gly Leu Pro Thr Leu Leu Pro
         515                 520                 525            
 His Pro Gly Pro Phe Gly Ser Leu Gln Gly Ala Phe Gln Pro Lys Val
     530                 535                 540                
 Ser Asp Pro Tyr Arg Ala Val Val Lys Val Ser Thr Cys Trp Glu Gly
 545                 550                 555                 560
 Pro Trp Gln Gly Arg Thr Leu Val Pro Pro Gly Arg Pro Arg Gly Ala
                 565                 570                 575    
 Arg Asp Ser Arg Ser Leu Gln Lys Thr Trp Val Gly Val Ala Pro Ala
             580                 585                 590        
 Pro Leu Ser Ala Ser Ile Leu Ser Gln Lys Pro Gly Arg Trp Cys Ala
         595                 600                 605            
 Val His Val Gln Ile Ala Trp Gln Ile Tyr Arg His Gln Gln Lys Ile
     610                 615                 620                
 Lys Glu Met Gln Leu Asp Pro His Lys Leu Glu Val Gly Ala Lys Leu
 625                 630                 635                 640
 Asp Leu Phe Gly Arg Pro Pro Ala Pro Gly Val Phe Ala Gly Phe His
                 645                 650                 655    
 Tyr Pro Gln Asp Leu Ala Arg Pro Leu Phe Pro Ser Thr Gly Ala Ala
             660                 665                 670        
 His Pro Ala Ser Asn Pro Phe Gly Pro Ser Ala His Pro Gly Ser Phe
         675                 680                 685            
 Leu Pro Thr Gly Pro Leu Thr Asp Pro Phe Ser Arg Pro Ser Thr Phe
     690                 695                 700                
 Gly Gly Leu Gly Ser Leu Ser Ser His Ala Phe Gly Gly Leu Gly Ser
 705                 710                 715                 720
 His Ala Leu Ala Pro Gly Gly Ser Ile Phe Ala Pro Arg Glu Gly Ser
                 725                 730                 735    
 Ser Val His Gly Leu Pro Ser Pro His Glu Ala Trp Asn Arg Leu His
             740                 745                 750        
 Arg Ala Pro Pro Ser Phe Pro Ala Pro Pro Pro Trp Pro Lys Ser Val
         755                 760                 765            
 Asp Ala Glu Arg Val Ser Ala Leu Thr Asn His Asp Arg Glu Pro Asp
     770                 775                 780                
 Asn Gly Lys Glu Glu Gln Glu Arg Asp Leu Leu Glu Lys Thr Arg Leu
 785                 790                 795                 800
 Leu Ser Arg Ala Ser Pro Ala Thr Pro Ala Gly His Pro Val Ser Gly
                 805                 810                 815    
 Leu Leu Leu Arg Ala Gln Ser Glu Leu Gly Arg Ser Gly Ala Pro Ala
             820                 825                 830        
 Glu Arg Glu Ala Glu Pro Arg Val Lys Glu Ser Arg Ser Pro Ala Lys
         835                 840                 845            
 Glu Glu Val Ala Lys Met Pro Ala Arg Ala Ser Pro Pro His Ser Lys
     850                 855                 860                
 Ala Ala Pro Gly Asp Val Lys Val Lys Glu Glu Arg Gly Glu Asp Glu
 865                 870                 875                 880
 Ala Ser Glu Pro Pro Ala Gly Gly Leu His Pro Ala Pro Leu Gln Leu
                 885                 890                 895    
 Gly Leu Gly Arg Glu Arg Leu Gly Ala Pro Gly Phe Ala Trp Glu Pro
             900                 905                 910        
 Phe Arg Gly Leu Glu Leu Pro Arg Arg Ala Phe Pro Ala Ala Ala Pro
         915                 920                 925            
 Ala Pro Gly Ser Ala Ala Leu Leu Glu Pro Pro Glu Arg Pro Tyr Arg
     930                 935                 940                
 Asp Arg Glu Pro His Gly Tyr Ser Pro Glu Arg Leu Arg Gly Glu Leu
 945                 950                 955                 960
 Glu Arg Ala Arg Ala Pro His Leu Pro Pro Ala Ala Pro Ala Leu Asp
                 965                 970                 975    
 Gly Ala Leu Leu Pro Ser Leu Gly Ala Leu His Phe Pro Arg Leu Ser
             980                 985                 990        
 Pro Ala Ala Leu His Asn Gly Leu Leu Ala Arg Thr Pro Pro Ala Ala
         995                1000                1005            
 Ala Ala Leu Gly Ala Pro Pro Pro Leu Val Thr Ala Ala Gly Pro Pro
    1010                1015                1020                
 Thr Pro Pro Gly Pro Pro Arg Ser Arg Thr Thr Pro Leu Gly Gly Leu
1025                1030                1035                1040
 Gly Pro Gly Glu Ala Arg Asp Tyr Ser Pro Ser Arg Asn Pro Pro Glu
                1045                1050                1055    
 Val Glu Ala Arg
            1060



      <210> 702
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 702
 Met Glu Phe Pro Asp Leu Gly Lys His Cys Ser Glu Lys Thr Cys Lys
   1               5                  10                  15    
 Gln Leu Asp Phe Leu Pro Val Lys Cys Asp Ala Cys Lys Gln Asp Phe
              20                  25                  30        
 Cys Lys Asp His Phe Pro Tyr Ala Ala His Lys Cys Pro Phe Ala Phe
          35                  40                  45            
 Gln Lys Asp Val His Val Pro Val Cys Pro Leu Cys Asn Thr Pro Ile
      50                  55                  60                
 Pro Val Lys Lys Gly Gln Ile Pro Asp Val Val Val Gly Asp His Ile
  65                  70                  75                  80
 Asp Arg Asp Cys Asp Ser His Pro Gly Lys Lys Lys Glu Lys Ile Phe
                  85                  90                  95    
 Thr Tyr Arg Cys Ser Lys Glu Gly Cys Lys Lys Lys Glu Met Leu Gln
             100                 105                 110        
 Met Val Cys Ala Gln Cys His Gly Asn Phe Cys Ile Gln His Arg His
         115                 120                 125            
 Pro Leu Asp His Ser Cys Arg His Gly Ser Arg Pro Thr Ile Lys Ala
     130                 135                 140                
 Gly
 145



      <210> 703
      <211> 403
      <212> PRT
      <213> Homo sapiens


      <400> 703
 Met Ser Gly Arg Val Gly Asp Leu Ser Pro Arg Gln Lys Glu Ala Leu
   1               5                  10                  15    
 Ala Lys Phe Arg Glu Asn Val Gln Asp Val Leu Pro Ala Leu Pro Asn
              20                  25                  30        
 Pro Asp Asp Tyr Phe Leu Leu Arg Trp Leu Arg Ala Arg Ser Phe Asp
          35                  40                  45            
 Leu Gln Lys Ser Glu Ala Met Leu Arg Lys His Val Glu Phe Arg Lys
      50                  55                  60                
 Gln Lys Asp Ile Asp Asn Ile Ile Ser Trp Gln Pro Pro Glu Val Ile
  65                  70                  75                  80
 Gln Gln Tyr Leu Ser Gly Gly Met Cys Gly Tyr Asp Leu Asp Gly Cys
                  85                  90                  95    
 Pro Val Trp Tyr Asp Ile Ile Gly Pro Leu Asp Ala Lys Gly Leu Leu
             100                 105                 110        
 Phe Ser Ala Ser Lys Gln Asp Leu Leu Arg Thr Lys Met Arg Glu Cys
         115                 120                 125            
 Glu Leu Leu Leu Gln Glu Cys Ala His Gln Thr Thr Lys Leu Gly Arg
     130                 135                 140                
 Lys Val Glu Thr Ile Thr Ile Ile Tyr Asp Cys Glu Gly Leu Gly Leu
 145                 150                 155                 160
 Lys His Leu Trp Lys Pro Ala Val Glu Ala Tyr Gly Glu Phe Leu Cys
                 165                 170                 175    
 Met Phe Glu Glu Asn Tyr Pro Glu Thr Leu Lys Arg Leu Phe Val Val
             180                 185                 190        
 Lys Ala Pro Lys Leu Phe Pro Val Ala Tyr Asn Leu Ile Lys Pro Phe
         195                 200                 205            
 Leu Ser Glu Asp Thr Arg Lys Lys Ile Met Val Leu Gly Ala Asn Trp
     210                 215                 220                
 Lys Glu Val Leu Leu Lys His Ile Ser Pro Asp Gln Val Pro Val Glu
 225                 230                 235                 240
 Tyr Gly Gly Thr Met Thr Asp Pro Asp Gly Asn Pro Lys Cys Lys Ser
                 245                 250                 255    
 Lys Ile Asn Tyr Gly Gly Asp Ile Pro Arg Lys Tyr Tyr Val Arg Asp
             260                 265                 270        
 Gln Val Lys Gln Gln Tyr Glu His Ser Val Gln Ile Ser Arg Gly Ser
         275                 280                 285            
 Ser His Gln Val Glu Tyr Glu Ile Leu Phe Pro Gly Cys Val Leu Arg
     290                 295                 300                
 Trp Gln Phe Met Ser Asp Gly Ala Asp Val Gly Phe Gly Ile Phe Leu
 305                 310                 315                 320
 Lys Thr Lys Met Gly Glu Arg Gln Arg Ala Gly Glu Met Thr Glu Val
                 325                 330                 335    
 Leu Pro Asn Gln Arg Tyr Asn Ser His Leu Val Pro Glu Asp Gly Thr
             340                 345                 350        
 Leu Thr Cys Ser Asp Pro Gly Ile Tyr Val Leu Arg Phe Asp Asn Thr
         355                 360                 365            
 Tyr Ser Phe Ile His Ala Lys Lys Val Asn Phe Thr Val Glu Val Leu
     370                 375                 380                
 Leu Pro Asp Lys Ala Ser Glu Glu Lys Met Lys Gln Leu Gly Ala Gly
 385                 390                 395                 400
 Thr Pro Lys
            



      <210> 704
      <211> 329
      <212> PRT
      <213> Homo sapiens


      <400> 704
 Met Ala Cys Arg Gly Trp Ala Gln Arg Gly Trp Gly Cys Gly Gln Ala
   1               5                  10                  15    
 Trp Gly Ala Ser Val Gly Gly Arg Ser Cys Glu Glu Leu Thr Ala Val
              20                  25                  30        
 Leu Thr Pro Pro Gln Leu Leu Gly Arg Arg Phe Asn Phe Phe Ile Gln
          35                  40                  45            
 Gln Lys Cys Gly Phe Arg Lys Ala Pro Arg Lys Val Glu Pro Arg Arg
      50                  55                  60                
 Ser Asp Pro Gly Thr Ser Gly Glu Ala Tyr Lys Arg Ser Ala Leu Ile
  65                  70                  75                  80
 Pro Pro Val Glu Glu Thr Val Phe Tyr Pro Ser Pro Tyr Pro Ile Arg
                  85                  90                  95    
 Ser Leu Ile Lys Pro Leu Phe Phe Thr Val Gly Phe Thr Gly Cys Ala
             100                 105                 110        
 Phe Gly Ser Ala Ala Ile Trp Gln Tyr Glu Ser Leu Lys Ser Arg Val
         115                 120                 125            
 Gln Ser Tyr Phe Asp Gly Ile Lys Ala Asp Trp Leu Asp Ser Ile Arg
     130                 135                 140                
 Pro Gln Lys Glu Gly Asp Phe Arg Lys Glu Ile Asn Lys Trp Trp Asn
 145                 150                 155                 160
 Asn Leu Ser Asp Gly Gln Arg Thr Val Thr Gly Ile Ile Ala Ala Asn
                 165                 170                 175    
 Val Leu Val Phe Cys Leu Trp Arg Val Pro Ser Leu Gln Arg Thr Met
             180                 185                 190        
 Ile Arg Tyr Phe Thr Ser Asn Pro Ala Ser Ser Val Ile Ser Asn Phe
         195                 200                 205            
 Val Ser Tyr Val Gly Lys Val Ala Thr Gly Arg Tyr Gly Pro Ser Leu
     210                 215                 220                
 Gly Ala Ser Gly Ala Ile Met Thr Val Leu Ala Ala Val Cys Thr Lys
 225                 230                 235                 240
 Ile Pro Glu Gly Arg Leu Ala Ile Ile Phe Leu Pro Met Phe Thr Phe
                 245                 250                 255    
 Thr Ala Gly Asn Ala Leu Lys Ala Ile Ile Ala Met Asp Thr Ala Gly
             260                 265                 270        
 Met Ile Leu Gly Trp Lys Phe Phe Asp His Ala Ala His Leu Gly Gly
         275                 280                 285            
 Ala Leu Phe Gly Ile Trp Tyr Val Thr Tyr Gly His Glu Leu Ile Trp
     290                 295                 300                
 Lys Asn Arg Glu Pro Leu Val Lys Ile Trp His Glu Ile Arg Thr Asn
 305                 310                 315                 320
 Gly Pro Lys Lys Gly Gly Gly Ser Lys
                 325                



      <210> 705
      <211> 979
      <212> PRT
      <213> Homo sapiens


      <400> 705
 Met Arg Gly Tyr His Gly Asp Arg Gly Ser His Pro Arg Pro Ala Arg
   1               5                  10                  15    
 Phe Ala Asp Gln Gln His Met Asp Val Gly Pro Ala Ala Arg Ala Pro
              20                  25                  30        
 Tyr Leu Leu Gly Ser Arg Glu Ala Phe Ser Thr Glu Pro Arg Phe Cys
          35                  40                  45            
 Ala Pro Arg Ala Gly Leu Gly His Ile Ser Pro Glu Gly Pro Leu Ser
      50                  55                  60                
 Leu Ser Glu Gly Pro Ser Val Gly Pro Glu Gly Gly Pro Ala Gly Ala
  65                  70                  75                  80
 Gly Val Gly Gly Gly Ser Ser Thr Phe Pro Arg Met Tyr Pro Gly Gln
                  85                  90                  95    
 Gly Pro Phe Asp Thr Cys Glu Asp Cys Val Gly His Pro Gln Gly Lys
             100                 105                 110        
 Gly Ala Pro Arg Leu Pro Pro Thr Leu Leu Asp Gln Phe Glu Lys Gln
         115                 120                 125            
 Leu Pro Val Gln Gln Asp Gly Phe His Thr Leu Pro Tyr Gln Arg Gly
     130                 135                 140                
 Pro Ala Gly Ala Gly Pro Gly Pro Ala Pro Gly Thr Gly Thr Ala Pro
 145                 150                 155                 160
 Glu Pro Arg Ser Glu Ser Pro Ser Arg Ile Arg His Leu Val His Ser
                 165                 170                 175    
 Val Gln Lys Leu Phe Ala Lys Ser His Ser Leu Glu Ala Pro Gly Lys
             180                 185                 190        
 Arg Asp Tyr Asn Gly Pro Lys Ala Glu Gly Arg Gly Gly Ser Gly Gly
         195                 200                 205            
 Asp Ser Tyr Pro Gly Pro Gly Ser Gly Gly Pro His Thr Ser His His
     210                 215                 220                
 His His His His His His His His His His Gln Ser Arg His Gly Lys
 225                 230                 235                 240
 Arg Ser Lys Ser Lys Asp Arg Lys Gly Asp Gly Arg His Gln Ala Lys
                 245                 250                 255    
 Ser Thr Gly Trp Trp Ser Ser Asp Asp Asn Leu Asp Ser Asp Ser Gly
             260                 265                 270        
 Phe Leu Ala Gly Gly Arg Pro Pro Gly Glu Pro Gly Gly Pro Phe Cys
         275                 280                 285            
 Leu Glu Gly Pro Asp Gly Ser Tyr Arg Asp Leu Ser Phe Lys Gly Arg
     290                 295                 300                
 Ser Gly Gly Ser Glu Gly Arg Cys Leu Ala Cys Thr Gly Met Ser Met
 305                 310                 315                 320
 Ser Leu Asp Gly Gln Ser Val Lys Arg Ser Ala Trp His Thr Met Met
                 325                 330                 335    
 Val Ser Gln Gly Arg Asp Gly Tyr Pro Gly Ala Gly Pro Gly Lys Gly
             340                 345                 350        
 Leu Leu Gly Pro Glu Thr Lys Ala Lys Ala Arg Thr Tyr His Tyr Leu
         355                 360                 365            
 Gln Val Pro Gln Asp Asp Trp Gly Gly Tyr Pro Thr Gly Gly Lys Asp
     370                 375                 380                
 Gly Glu Ile Pro Cys Arg Arg Met Arg Ser Gly Ser Tyr Ile Lys Ala
 385                 390                 395                 400
 Met Gly Asp Glu Glu Ser Gly Asp Ser Asp Gly Ser Pro Lys Thr Ser
                 405                 410                 415    
 Pro Lys Ala Val Ala Arg Arg Phe Thr Thr Arg Arg Ser Ser Ser Val
             420                 425                 430        
 Asp Gln Ala Arg Ile Ser Cys Cys Val Pro Pro Arg Ile His Pro Arg
         435                 440                 445            
 Ser Ser Ile Pro Gly Tyr Ser Arg Ser Leu Thr Thr Gly Gln Leu Ser
     450                 455                 460                
 Asp Glu Leu Asn Gln Gln Leu Glu Ala Val Cys Gly Ser Val Phe Gly
 465                 470                 475                 480
 Glu Leu Glu Ser Gln Ala Val Asp Ala Leu Asp Leu Pro Gly Cys Phe
                 485                 490                 495    
 Arg Met Arg Ser His Ser Tyr Leu Arg Ala Ile Gln Ala Gly Cys Ser
             500                 505                 510        
 Gln Asp Asp Asp Cys Leu Pro Leu Leu Ala Thr Pro Ala Ala Val Ser
         515                 520                 525            
 Gly Arg Pro Gly Ser Ser Phe Asn Phe Arg Lys Ala Pro Pro Pro Ile
     530                 535                 540                
 Pro Pro Gly Ser Gln Ala Pro Pro Arg Ile Ser Ile Thr Ala Gln Ser
 545                 550                 555                 560
 Ser Thr Asp Ser Ala His Glu Ser Phe Thr Ala Ala Glu Gly Pro Ala
                 565                 570                 575    
 Arg Arg Cys Ser Ser Ala Asp Gly Leu Asp Gly Pro Ala Met Gly Ala
             580                 585                 590        
 Arg Thr Leu Glu Leu Ala Pro Val Pro Pro Arg Ala Ser Pro Lys Pro
         595                 600                 605            
 Pro Thr Leu Ile Ile Lys Thr Ile Pro Gly Arg Glu Glu Leu Arg Ser
     610                 615                 620                
 Leu Ala Arg Gln Arg Lys Trp Arg Pro Ser Ile Gly Val Gln Val Glu
 625                 630                 635                 640
 Thr Ile Ser Asp Ser Asp Thr Glu Asn Arg Ser Arg Arg Glu Phe His
                 645                 650                 655    
 Ser Ile Gly Val Gln Val Glu Glu Asp Lys Arg Arg Ala Arg Phe Lys
             660                 665                 670        
 Arg Ser Asn Ser Val Thr Ala Gly Val Gln Ala Asp Leu Glu Leu Glu
         675                 680                 685            
 Gly Leu Ala Gly Leu Ala Thr Val Ala Thr Glu Asp Lys Ala Leu Gln
     690                 695                 700                
 Phe Gly Arg Ser Phe Gln Arg His Ala Ser Glu Pro Gln Pro Gly Pro
 705                 710                 715                 720
 Arg Ala Pro Thr Tyr Ser Val Phe Arg Thr Val His Thr Gln Gly Gln
                 725                 730                 735    
 Trp Ala Tyr Arg Glu Gly Tyr Pro Leu Pro Tyr Glu Pro Pro Ala Thr
             740                 745                 750        
 Asp Gly Ser Pro Gly Pro Ala Pro Ala Pro Thr Pro Cys Pro Gly Ala
         755                 760                 765            
 Gly Arg Arg Asp Ser Trp Ile Glu Arg Gly Ser Arg Ser Leu Pro Asp
     770                 775                 780                
 Ser Gly Arg Ala Ser Pro Cys Pro Arg Asp Gly Glu Trp Phe Ile Lys
 785                 790                 795                 800
 Met Leu Arg Ala Glu Val Glu Lys Leu Glu His Trp Cys Gln Gln Met
                 805                 810                 815    
 Glu Arg Glu Ala Glu Asp Tyr Glu Leu Pro Glu Glu Ile Leu Glu Lys
             820                 825                 830        
 Ile Arg Ser Ala Val Gly Ser Thr Gln Leu Leu Leu Ser Gln Lys Val
         835                 840                 845            
 Gln Gln Phe Phe Arg Leu Cys Gln Gln Ser Met Asp Pro Thr Ala Phe
     850                 855                 860                
 Pro Val Pro Thr Phe Gln Asp Leu Ala Gly Phe Trp Asp Leu Leu Gln
 865                 870                 875                 880
 Leu Ser Ile Glu Asp Val Thr Leu Lys Phe Leu Glu Leu Gln Gln Leu
                 885                 890                 895    
 Lys Ala Asn Ser Trp Lys Leu Leu Glu Pro Lys Glu Glu Lys Lys Val
             900                 905                 910        
 Pro Pro Pro Ile Pro Lys Lys Pro Leu Arg Gly Arg Gly Val Pro Val
         915                 920                 925            
 Lys Glu Arg Ser Leu Asp Ser Val Asp Arg Gln Arg Gln Glu Ala Arg
     930                 935                 940                
 Lys Arg Leu Leu Ala Ala Lys Arg Ala Ala Ser Phe Arg His Ser Ser
 945                 950                 955                 960
 Ala Thr Glu Ser Ala Asp Ser Ile Glu Ile Tyr Ile Pro Glu Ala Gln
                 965                 970                 975    
 Thr Arg Leu
            



      <210> 706
      <211> 458
      <212> PRT
      <213> Homo sapiens


      <400> 706
 Met Ala Trp Ala Ser Arg Leu Gly Leu Leu Leu Ala Leu Leu Leu Pro
   1               5                  10                  15    
 Val Val Gly Ala Ser Thr Pro Gly Thr Val Val Arg Leu Asn Lys Ala
              20                  25                  30        
 Ala Leu Ser Tyr Val Ser Glu Ile Gly Lys Ala Pro Leu Gln Arg Ala
          35                  40                  45            
 Leu Gln Val Thr Val Pro His Phe Leu Asp Trp Ser Gly Glu Ala Leu
      50                  55                  60                
 Gln Pro Thr Arg Ile Arg Ile Leu Asn Val His Val Pro Arg Leu His
  65                  70                  75                  80
 Leu Lys Phe Ile Ala Gly Phe Gly Val Arg Leu Leu Ala Ala Ala Asn
                  85                  90                  95    
 Phe Thr Phe Lys Val Phe Arg Ala Pro Glu Pro Leu Glu Leu Thr Leu
             100                 105                 110        
 Pro Val Glu Leu Leu Ala Asp Thr Arg Val Thr Gln Ser Ser Ile Arg
         115                 120                 125            
 Thr Pro Val Val Ser Ile Ser Ala Cys Ser Leu Phe Ser Gly His Ala
     130                 135                 140                
 Asn Glu Phe Asp Gly Ser Asn Ser Thr Ser His Ala Leu Leu Val Leu
 145                 150                 155                 160
 Val Gln Lys His Ile Lys Ala Val Leu Ser Asn Lys Leu Cys Leu Ser
                 165                 170                 175    
 Thr Ser Asn Leu Val Gln Gly Val Asn Val His Leu Gly Thr Leu Ile
             180                 185                 190        
 Gly Leu Asn Pro Val Gly Pro Glu Ser Gln Ile Arg Tyr Ser Met Val
         195                 200                 205            
 Ser Val Pro Thr Val Thr Ser Asp Tyr Ile Ser Leu Glu Val Asn Ala
     210                 215                 220                
 Val Leu Phe Leu Leu Gly Lys Pro Ile Ile Leu Pro Thr Asp Ala Thr
 225                 230                 235                 240
 Pro Phe Val Leu Pro Arg His Val Gly Thr Glu Gly Ser Met Ala Thr
                 245                 250                 255    
 Val Gly Leu Ser Gln Gln Leu Phe Asp Ser Ala Leu Leu Leu Leu Gln
             260                 265                 270        
 Lys Ala Gly Ala Leu Asn Leu Asp Ile Thr Gly Gln Leu Arg Ser Asp
         275                 280                 285            
 Asp Asn Leu Leu Asn Thr Ser Ala Leu Gly Arg Leu Ile Pro Glu Val
     290                 295                 300                
 Ala Arg Gln Phe Pro Glu Pro Met Pro Val Val Leu Lys Val Arg Leu
 305                 310                 315                 320
 Gly Ala Thr Pro Val Ala Met Leu His Thr Asn Asn Ala Thr Leu Arg
                 325                 330                 335    
 Leu Gln Pro Phe Val Glu Val Leu Ala Thr Ala Ser Asn Ser Ala Phe
             340                 345                 350        
 Gln Ser Leu Phe Ser Leu Asp Val Val Val Asn Leu Arg Leu Gln Leu
         355                 360                 365            
 Ser Val Ser Lys Val Lys Leu Gln Gly Thr Thr Ser Val Leu Gly Asp
     370                 375                 380                
 Val Gln Leu Thr Val Ala Ser Ser Asn Val Gly Phe Ile Asp Thr Asp
 385                 390                 395                 400
 Gln Val Arg Thr Leu Met Gly Thr Val Phe Glu Lys Pro Leu Leu Asp
                 405                 410                 415    
 His Leu Asn Ala Leu Leu Ala Met Gly Ile Ala Leu Pro Gly Val Val
             420                 425                 430        
 Asn Leu His Tyr Val Ala Pro Glu Ile Phe Val Tyr Glu Gly Tyr Val
         435                 440                 445            
 Val Ile Ser Ser Gly Leu Phe Tyr Gln Ser
     450                 455            



      <210> 707
      <211> 380
      <212> PRT
      <213> Homo sapiens


      <400> 707
 Met Ala Arg Leu Gly Ala Val Arg Ser His Tyr Cys Ala Leu Leu Leu
   1               5                  10                  15    
 Ala Ala Ala Leu Ala Val Cys Ala Phe Tyr Tyr Leu Gly Ser Gly Arg
              20                  25                  30        
 Glu Thr Phe Ser Ser Ala Thr Lys Arg Leu Lys Glu Ala Arg Ala Gly
          35                  40                  45            
 Ala Pro Ala Ala Pro Ser Pro Pro Ala Leu Glu Leu Ala Arg Gly Ser
      50                  55                  60                
 Val Ala Pro Ala Pro Gly Ala Lys Ala Lys Ser Leu Glu Gly Gly Gly
  65                  70                  75                  80
 Ala Gly Pro Val Asp Tyr His Leu Leu Met Met Phe Thr Lys Ala Glu
                  85                  90                  95    
 His Asn Ala Ala Leu Gln Ala Lys Ala Arg Val Ala Leu Arg Ser Leu
             100                 105                 110        
 Leu Arg Leu Ala Lys Phe Glu Ala His Glu Val Leu Asn Leu His Phe
         115                 120                 125            
 Val Ser Glu Glu Ala Ser Arg Glu Val Ala Lys Gly Leu Leu Arg Glu
     130                 135                 140                
 Leu Leu Pro Pro Ala Ala Gly Phe Lys Cys Lys Val Ile Phe His Asp
 145                 150                 155                 160
 Val Ala Val Leu Thr Asp Lys Leu Phe Pro Ile Val Glu Ala Met Gln
                 165                 170                 175    
 Lys His Phe Ser Ala Gly Leu Gly Thr Tyr Tyr Ser Asp Ser Ile Phe
             180                 185                 190        
 Phe Leu Ser Val Ala Met His Gln Ile Met Pro Lys Glu Ile Leu Gln
         195                 200                 205            
 Ile Ile Gln Leu Asp Leu Asp Leu Lys Phe Lys Thr Asn Ile Arg Glu
     210                 215                 220                
 Leu Phe Glu Glu Phe Asp Ser Phe Leu Pro Gly Ala Ile Ile Gly Ile
 225                 230                 235                 240
 Ala Arg Glu Met Gln Pro Val Tyr Arg His Thr Phe Trp Gln Phe Arg
                 245                 250                 255    
 His Glu Asn Pro Gln Thr Arg Val Gly Gly Pro Pro Pro Glu Gly Leu
             260                 265                 270        
 Pro Gly Phe Asn Ser Gly Val Met Leu Leu Asn Leu Glu Ala Met Arg
         275                 280                 285            
 Gln Ser Pro Leu Tyr Ser Arg Leu Leu Glu Pro Ala Gln Val Gln Gln
     290                 295                 300                
 Leu Ala Asp Lys Tyr His Phe Arg Gly His Leu Gly Asp Gln Asp Phe
 305                 310                 315                 320
 Phe Thr Met Ile Gly Met Glu His Pro Lys Leu Phe His Val Leu Asp
                 325                 330                 335    
 Cys Thr Trp Asn Arg Gln Leu Cys Thr Trp Trp Arg Asp His Gly Tyr
             340                 345                 350        
 Ser Asp Val Phe Glu Ala Tyr Phe Arg Cys Glu Gly His Val Lys Ile
         355                 360                 365            
 Tyr His Gly Asn Cys Asn Thr Pro Ile Pro Glu Asp
     370                 375                 380



      <210> 708
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 708
 Met Lys Thr Phe Thr Gly Glu Thr Ser Leu Ser Pro Gly Cys Gly Glu
   1               5                  10                  15    
 Pro Val Tyr Phe Ala Glu Lys Val Met Ser Leu Gly Arg Asn Trp His
              20                  25                  30        
 Arg Pro Cys Leu Arg Cys Gln Arg Cys His Lys Thr Leu Thr Ala Gly
          35                  40                  45            
 Ser His Ala Glu His Asp Gly Val Pro Tyr Cys His Val Pro Cys Tyr
      50                  55                  60                
 Gly Tyr Leu Phe Gly Pro Lys Gly Val Asn Thr Gly Asp Val Gly Cys
  65                  70                  75                  80
 Tyr Ile Tyr Asp Pro Val Lys Ile Lys Phe Lys
                  85                  90    



      <210> 709
      <211> 396
      <212> PRT
      <213> Homo sapiens


      <400> 709
 Met Gly Glu Arg Lys Gly Val Asn Lys Tyr Tyr Pro Pro Asp Phe Asn
   1               5                  10                  15    
 Pro Glu Lys His Gly Ser Leu Asn Arg Tyr His Asn Ser His Pro Leu
              20                  25                  30        
 Arg Glu Arg Ala Arg Lys Leu Ser Gln Gly Ile Leu Ile Ile Arg Phe
          35                  40                  45            
 Glu Met Pro Tyr Asn Ile Trp Cys Asp Gly Cys Lys Asn His Ile Gly
      50                  55                  60                
 Met Gly Val Arg Tyr Asn Ala Glu Lys Lys Lys Val Gly Asn Tyr Tyr
  65                  70                  75                  80
 Thr Thr Pro Ile Tyr Arg Phe Arg Met Lys Cys His Leu Cys Val Asn
                  85                  90                  95    
 Tyr Ile Glu Met Gln Thr Asp Pro Ala Asn Cys Asp Tyr Val Ile Val
             100                 105                 110        
 Ser Gly Ala Gln Arg Lys Glu Glu Arg Trp Asp Met Ala Asp Asn Glu
         115                 120                 125            
 Gln Val Leu Thr Thr Glu His Glu Lys Lys Gln Lys Leu Glu Thr Asp
     130                 135                 140                
 Ala Met Phe Arg Leu Glu His Gly Glu Ala Asp Arg Ser Thr Leu Lys
 145                 150                 155                 160
 Lys Ala Leu Pro Thr Leu Ser His Ile Gln Glu Ala Gln Ser Ala Trp
                 165                 170                 175    
 Lys Asp Asp Phe Ala Leu Asn Ser Met Leu Arg Arg Arg Phe Arg Glu
             180                 185                 190        
 Lys Lys Lys Ala Ile Gln Glu Glu Glu Glu Arg Asp Gln Ala Leu Gln
         195                 200                 205            
 Ala Lys Ala Ser Leu Thr Ile Pro Leu Val Pro Glu Thr Glu Asp Asp
     210                 215                 220                
 Arg Lys Leu Ala Ala Leu Leu Lys Phe His Thr Leu Asp Ser Tyr Glu
 225                 230                 235                 240
 Asp Lys Gln Lys Leu Lys Arg Thr Glu Ile Ile Ser Arg Ser Trp Phe
                 245                 250                 255    
 Pro Ser Ala Pro Gly Ser Ala Ser Ser Ser Lys Val Ser Gly Val Leu
             260                 265                 270        
 Lys Lys Leu Ala Gln Ser Arg Arg Thr Ala Leu Ala Thr Ser Pro Ile
         275                 280                 285            
 Thr Val Gly Asp Leu Gly Ile Val Arg Arg Arg Ser Arg Asp Val Pro
     290                 295                 300                
 Glu Ser Pro Gln His Ala Ala Asp Thr Pro Lys Ser Gly Glu Pro Arg
 305                 310                 315                 320
 Val Pro Glu Glu Ala Ala Gln Asp Arg Pro Met Ser Pro Gly Asp Cys
                 325                 330                 335    
 Pro Pro Glu Thr Thr Glu Thr Pro Lys Cys Ser Ser Pro Arg Gly Gln
             340                 345                 350        
 Glu Gly Ser Arg Gln Asp Lys Pro Leu Ser Pro Ala Gly Ser Ser Gln
         355                 360                 365            
 Glu Ala Ala Asp Thr Pro Asp Thr Arg His Pro Cys Ser Leu Gly Ser
     370                 375                 380                
 Ser Leu Val Ala Asp Tyr Ser Asp Ser Glu Ser Glu
 385                 390                 395    



      <210> 710
      <211> 1712
      <212> PRT
      <213> Homo sapiens


      <400> 710
 Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp
   1               5                  10                  15    
 Leu Leu Leu Gly Thr Val Thr Val Gly Phe Leu Ala Gln Ser Val Leu
              20                  25                  30        
 Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser
          35                  40                  45            
 Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly
      50                  55                  60                
 Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe
  65                  70                  75                  80
 Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro
                  85                  90                  95    
 Gly Val Thr Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser Gly
             100                 105                 110        
 Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln Gly Gly Pro
         115                 120                 125            
 Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly Thr Gln Gly Asp Ser
     130                 135                 140                
 Gly Pro Gln Gly Pro Pro Gly Ser Glu Gly Phe Thr Gly Pro Pro Gly
 145                 150                 155                 160
 Pro Gln Gly Pro Lys Gly Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys
                 165                 170                 175    
 Glu Glu Arg Asp Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val
             180                 185                 190        
 Gly Phe Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly
         195                 200                 205            
 Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro
     210                 215                 220                
 Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys Gly
 225                 230                 235                 240
 Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly Ile Pro Ser Asp
                 245                 250                 255    
 Thr Leu His Pro Ile Ile Ala Pro Thr Gly Val Thr Phe His Pro Asp
             260                 265                 270        
 Gln Tyr Lys Gly Glu Lys Gly Ser Glu Gly Glu Pro Gly Ile Arg Gly
         275                 280                 285            
 Ile Ser Leu Lys Gly Glu Glu Gly Ile Met Gly Phe Pro Gly Leu Arg
     290                 295                 300                
 Gly Tyr Pro Gly Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly
 305                 310                 315                 320
 Ser Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro
                 325                 330                 335    
 Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser
             340                 345                 350        
 Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly Phe Pro
         355                 360                 365            
 Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro Gly Asp Pro Gly
     370                 375                 380                
 Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly Asp Gly Asp Gln Arg Arg
 385                 390                 395                 400
 Gly Leu Pro Gly Glu Met Gly Pro Lys Gly Phe Ile Gly Asp Pro Gly
                 405                 410                 415    
 Ile Pro Ala Leu Tyr Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly
             420                 425                 430        
 Pro Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe
         435                 440                 445            
 Leu Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu
     450                 455                 460                
 Pro Gly Ser Pro Gly Ala Pro Gly Pro Lys Gly Trp Lys Gly Asp Ala
 465                 470                 475                 480
 Gly Glu Cys Arg Cys Thr Glu Gly Asp Glu Ala Ile Lys Gly Leu Pro
                 485                 490                 495    
 Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile Asn Gly Glu Pro Gly
             500                 505                 510        
 Arg Lys Gly Asp Lys Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe
         515                 520                 525            
 Pro Gly Leu Lys Gly Val Pro Gly Asn Ile Gly Ala Pro Gly Pro Lys
     530                 535                 540                
 Gly Ala Lys Gly Asp Ser Arg Thr Ile Thr Thr Lys Gly Glu Arg Gly
 545                 550                 555                 560
 Gln Pro Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser
                 565                 570                 575    
 Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro
             580                 585                 590        
 Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly Ile
         595                 600                 605            
 Pro Gly Thr Lys Gly Thr Pro Gly Glu Met Gly Pro Pro Gly Leu Gly
     610                 615                 620                
 Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro Gly Asp Ala Gly Leu
 625                 630                 635                 640
 Pro Gly Pro Pro Gly Phe Leu Gly Pro Pro Gly Pro Ala Gly Thr Pro
                 645                 650                 655    
 Gly Gln Ile Asp Cys Asp Thr Asp Val Lys Arg Ala Val Gly Gly Asp
             660                 665                 670        
 Arg Gln Glu Ala Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu
         675                 680                 685            
 Pro Gly Leu Pro Gly Pro Pro Gly Pro Thr Gly Ala Lys Gly Leu Arg
     690                 695                 700                
 Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly
 705                 710                 715                 720
 Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro Gly Phe
                 725                 730                 735    
 Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu Pro Gly Pro Asp
             740                 745                 750        
 Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly Pro Asp Gly Pro Pro Gly
         755                 760                 765            
 Glu Arg Gly Leu Pro Gly Glu Val Leu Gly Ala Gln Pro Gly Pro Arg
     770                 775                 780                
 Gly Asp Ala Gly Val Pro Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly
 785                 790                 795                 800
 Asp Arg Gly Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met
                 805                 810                 815    
 Pro Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro
             820                 825                 830        
 Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly
         835                 840                 845            
 Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu Gly Leu
     850                 855                 860                
 Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala Pro Gly Pro Val
 865                 870                 875                 880
 Gly Met Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala Gly Phe Thr Gly
                 885                 890                 895    
 Glu Gln Gly His Pro Gly Ser Pro Gly Phe Lys Gly Ile Asp Gly Met
             900                 905                 910        
 Pro Gly Thr Pro Gly Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp
         915                 920                 925            
 Gly Phe Gln Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly
     930                 935                 940                
 Ser Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu
 945                 950                 955                 960
 Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro Pro
                 965                 970                 975    
 Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile Lys Gly Glu
             980                 985                 990        
 Lys Gly Asp Glu Gly Pro Met Gly Leu Lys Gly Tyr Leu Gly Ala Lys
         995                1000                1005            
 Gly Ile Gln Gly Met Pro Gly Ile Pro Gly Leu Ser Gly Ile Pro Gly
    1010                1015                1020                
 Leu Pro Gly Arg Pro Gly His Ile Lys Gly Val Lys Gly Asp Ile Gly
1025                1030                1035                1040
 Val Pro Gly Ile Pro Gly Leu Pro Gly Phe Pro Gly Val Ala Gly Pro
                1045                1050                1055    
 Pro Gly Ile Thr Gly Phe Pro Gly Phe Ile Gly Ser Arg Gly Asp Lys
            1060                1065                1070        
 Gly Ala Pro Gly Arg Ala Gly Leu Tyr Gly Glu Ile Gly Ala Thr Gly
        1075                1080                1085            
 Asp Phe Gly Asp Ile Gly Asp Thr Ile Asn Leu Pro Gly Arg Pro Gly
    1090                1095                1100                
 Leu Lys Gly Glu Arg Gly Thr Thr Gly Ile Pro Gly Leu Lys Gly Phe
1105                1110                1115                1120
 Phe Gly Glu Lys Gly Thr Glu Gly Asp Ile Gly Phe Pro Gly Ile Thr
                1125                1130                1135    
 Gly Val Thr Gly Val Gln Gly Pro Pro Gly Leu Lys Gly Gln Thr Gly
            1140                1145                1150        
 Phe Pro Gly Leu Thr Gly Pro Pro Gly Ser Gln Gly Glu Leu Gly Arg
        1155                1160                1165            
 Ile Gly Leu Pro Gly Gly Lys Gly Asp Asp Gly Trp Pro Gly Ala Pro
    1170                1175                1180                
 Gly Leu Pro Gly Phe Pro Gly Leu Arg Gly Ile Arg Gly Leu His Gly
1185                1190                1195                1200
 Leu Pro Gly Thr Lys Gly Phe Pro Gly Ser Pro Gly Ser Asp Ile His
                1205                1210                1215    
 Gly Asp Pro Gly Phe Pro Gly Pro Pro Gly Glu Arg Gly Asp Pro Gly
            1220                1225                1230        
 Glu Ala Asn Thr Leu Pro Gly Pro Val Gly Val Pro Gly Gln Lys Gly
        1235                1240                1245            
 Asp Gln Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Ser Pro Gly Leu
    1250                1255                1260                
 Gln Gly Phe Pro Gly Ile Thr Pro Pro Ser Asn Ile Ser Gly Ala Pro
1265                1270                1275                1280
 Gly Asp Lys Gly Ala Pro Gly Ile Phe Gly Leu Lys Gly Tyr Arg Gly
                1285                1290                1295    
 Pro Pro Gly Pro Pro Gly Ser Ala Ala Leu Pro Gly Ser Lys Gly Asp
            1300                1305                1310        
 Thr Gly Asn Pro Gly Ala Pro Gly Thr Pro Gly Thr Lys Gly Trp Ala
        1315                1320                1325            
 Gly Asp Ser Gly Pro Gln Gly Arg Pro Gly Val Phe Gly Leu Pro Gly
    1330                1335                1340                
 Glu Lys Gly Pro Arg Gly Glu Gln Gly Phe Met Gly Asn Thr Gly Pro
1345                1350                1355                1360
 Thr Gly Ala Val Gly Asp Arg Gly Pro Lys Gly Pro Lys Gly Asp Pro
                1365                1370                1375    
 Gly Phe Pro Gly Ala Pro Gly Thr Val Gly Ala Pro Gly Ile Ala Gly
            1380                1385                1390        
 Ile Pro Gln Lys Ile Ala Val Gln Pro Gly Thr Val Gly Pro Gln Gly
        1395                1400                1405            
 Arg Arg Gly Pro Pro Gly Ala Pro Gly Glu Met Gly Pro Gln Gly Pro
    1410                1415                1420                
 Pro Gly Glu Pro Gly Phe Arg Gly Ala Pro Gly Lys Ala Gly Pro Gln
1425                1430                1435                1440
 Gly Arg Gly Gly Val Ser Ala Val Pro Gly Phe Arg Gly Asp Glu Gly
                1445                1450                1455    
 Pro Ile Gly His Gln Gly Pro Ile Gly Gln Glu Gly Ala Pro Gly Arg
            1460                1465                1470        
 Pro Gly Ser Pro Gly Leu Pro Gly Met Pro Gly Arg Ser Val Ser Ile
        1475                1480                1485            
 Gly Tyr Leu Leu Val Lys His Ser Gln Thr Asp Gln Glu Pro Met Cys
    1490                1495                1500                
 Pro Val Gly Met Asn Lys Leu Trp Ser Gly Tyr Ser Leu Leu Tyr Phe
1505                1510                1515                1520
 Glu Gly Gln Glu Lys Ala His Asn Gln Asp Leu Gly Leu Ala Gly Ser
                1525                1530                1535    
 Cys Leu Ala Arg Phe Ser Thr Met Pro Phe Leu Tyr Cys Asn Pro Gly
            1540                1545                1550        
 Asp Val Cys Tyr Tyr Ala Ser Arg Asn Asp Lys Ser Tyr Trp Leu Ser
        1555                1560                1565            
 Thr Thr Ala Pro Leu Pro Met Met Pro Val Ala Glu Asp Glu Ile Lys
    1570                1575                1580                
 Pro Tyr Ile Ser Arg Cys Ser Val Cys Glu Ala Pro Ala Ile Ala Ile
1585                1590                1595                1600
 Ala Val His Ser Gln Asp Val Ser Ile Pro His Cys Pro Ala Gly Trp
                1605                1610                1615    
 Arg Ser Leu Trp Ile Gly Tyr Ser Phe Leu Met His Thr Ala Ala Gly
            1620                1625                1630        
 Asp Glu Gly Gly Gly Gln Ser Leu Val Ser Pro Gly Ser Cys Leu Glu
        1635                1640                1645            
 Asp Phe Arg Ala Thr Pro Phe Ile Glu Cys Asn Gly Gly Arg Gly Thr
    1650                1655                1660                
 Cys His Tyr Tyr Ala Asn Lys Tyr Ser Phe Trp Leu Thr Thr Ile Pro
1665                1670                1675                1680
 Glu Gln Ser Phe Gln Gly Ser Pro Ser Ala Asp Thr Leu Lys Ala Gly
                1685                1690                1695    
 Leu Ile Arg Thr His Ile Ser Arg Cys Gln Val Cys Met Lys Asn Leu
            1700                1705                1710        





      <210> 711
      <211> 4636
      <212> PRT
      <213> Homo sapiens


      <400> 711
 Met Thr Pro Leu Gly Ser Arg Leu Gln Ala Ala Pro Ala Ala Ala Ala
   1               5                  10                  15    
 Ala Ala Gly Pro Lys Val Pro Pro Ser Ser Leu Gln Arg Arg Leu Pro
              20                  25                  30        
 Tyr Arg Ala Thr Thr Met Ser Glu Phe Leu Leu Ala Leu Leu Thr Leu
          35                  40                  45            
 Ser Gly Leu Leu Pro Ile Ala Arg Val Leu Thr Val Gly Ala Asp Arg
      50                  55                  60                
 Asp Gln Gln Leu Cys Asp Pro Gly Glu Phe Leu Cys His Asp His Val
  65                  70                  75                  80
 Thr Cys Val Ser Arg Ser Trp Leu Cys Asp Gly Asp Pro Asp Cys Pro
                  85                  90                  95    
 Asp Asp Ser Asp Glu Ser Leu Asp Thr Cys Pro Glu Glu Val Glu Ile
             100                 105                 110        
 Lys Cys Pro Leu Asn His Ile Ala Cys Leu Gly Thr Asn Lys Cys Val
         115                 120                 125            
 His Leu Ser Gln Leu Cys Asn Gly Val Leu Asp Cys Pro Asp Gly Tyr
     130                 135                 140                
 Asp Glu Gly Val His Cys Gln Glu Leu Leu Ser Asn Cys Gln Gln Leu
 145                 150                 155                 160
 Asn Cys Gln Tyr Lys Cys Thr Met Val Arg Asn Ser Thr Arg Cys Tyr
                 165                 170                 175    
 Cys Glu Asp Gly Phe Glu Ile Thr Glu Asp Gly Arg Ser Cys Lys Asp
             180                 185                 190        
 Gln Asp Glu Cys Ala Val Tyr Gly Thr Cys Ser Gln Thr Cys Arg Asn
         195                 200                 205            
 Thr His Gly Ser Tyr Thr Cys Ser Cys Val Glu Gly Tyr Leu Met Gln
     210                 215                 220                
 Pro Asp Asn Arg Ser Cys Lys Ala Lys Ile Glu Pro Thr Asp Arg Pro
 225                 230                 235                 240
 Pro Ile Leu Leu Ile Ala Asn Phe Glu Thr Ile Glu Val Phe Tyr Leu
                 245                 250                 255    
 Asn Gly Ser Lys Met Ala Thr Leu Ser Ser Val Asn Gly Asn Glu Ile
             260                 265                 270        
 His Thr Leu Asp Phe Ile Tyr Asn Glu Asp Val Ile Cys Trp Ile Glu
         275                 280                 285            
 Ser Arg Glu Ser Ser Asn Gln Leu Lys Cys Ile Gln Ile Thr Lys Ala
     290                 295                 300                
 Gly Gly Leu Thr Asp Glu Trp Thr Ile Asn Ile Leu Gln Ser Phe His
 305                 310                 315                 320
 Asn Val Gln Gln Met Ala Ile Asp Trp Leu Thr Arg Asn Leu Tyr Phe
                 325                 330                 335    
 Val Asp His Val Gly Asp Arg Ile Phe Val Cys Asn Ser Asn Gly Ser
             340                 345                 350        
 Val Cys Val Thr Leu Ile Asp Leu Glu Leu His Asn Pro Lys Ala Ile
         355                 360                 365            
 Ala Val Asp Pro Ile Ala Gly Lys Leu Phe Phe Thr Asp Tyr Gly Asn
     370                 375                 380                
 Val Ala Lys Val Glu Arg Cys Asp Met Asp Gly Met Asn Arg Thr Arg
 385                 390                 395                 400
 Ile Ile Asp Ser Lys Thr Glu Gln Pro Ala Ala Leu Ala Leu Asp Leu
                 405                 410                 415    
 Val Asn Lys Leu Val Tyr Trp Val Asp Leu Tyr Leu Asp Tyr Val Gly
             420                 425                 430        
 Val Val Asp Tyr Gln Gly Lys Asn Arg His Thr Val Ile Gln Gly Arg
         435                 440                 445            
 Gln Val Arg His Leu Tyr Gly Ile Thr Val Phe Glu Asp Tyr Leu Tyr
     450                 455                 460                
 Ala Thr Asn Ser Asp Asn Tyr Asn Ile Val Arg Ile Asn Arg Phe Asn
 465                 470                 475                 480
 Gly Thr Asp Ile His Ser Leu Ile Lys Ile Glu Asn Ala Trp Gly Ile
                 485                 490                 495    
 Arg Ile Tyr Gln Lys Arg Thr Gln Pro Thr Val Arg Ser His Ala Cys
             500                 505                 510        
 Glu Val Asp Pro Tyr Gly Met Pro Gly Gly Cys Ser His Ile Cys Leu
         515                 520                 525            
 Leu Ser Ser Ser Tyr Lys Thr Arg Thr Cys Arg Cys Arg Thr Gly Phe
     530                 535                 540                
 Asn Leu Gly Ser Asp Gly Arg Ser Cys Lys Arg Pro Lys Asn Glu Leu
 545                 550                 555                 560
 Phe Leu Phe Tyr Gly Lys Gly Arg Pro Gly Ile Val Arg Gly Met Asp
                 565                 570                 575    
 Leu Asn Thr Lys Ile Ala Asp Glu Tyr Met Ile Pro Ile Glu Asn Leu
             580                 585                 590        
 Val Asn Pro Arg Ala Leu Asp Phe His Ala Glu Thr Asn Tyr Ile Tyr
         595                 600                 605            
 Phe Ala Asp Thr Thr Ser Phe Leu Ile Gly Arg Gln Lys Ile Asp Gly
     610                 615                 620                
 Thr Glu Arg Glu Thr Ile Leu Lys Asp Asp Leu Asp Asn Val Glu Gly
 625                 630                 635                 640
 Ile Ala Val Asp Trp Ile Gly Asn Asn Leu Tyr Trp Thr Asn Asp Gly
                 645                 650                 655    
 His Arg Lys Thr Ile Asn Val Ala Arg Leu Glu Lys Ala Ser Gln Ser
             660                 665                 670        
 Arg Lys Thr Leu Leu Glu Gly Glu Met Ser His Pro Arg Gly Ile Val
         675                 680                 685            
 Val Asp Pro Ile Asn Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp
     690                 695                 700                
 Glu Ile Asp Asp Ser Val Gly Arg Ile Glu Lys Ala Trp Met Asp Gly
 705                 710                 715                 720
 Phe Asn Arg Gln Ile Phe Val Thr Ser Lys Met Leu Trp Pro Asn Gly
                 725                 730                 735    
 Leu Thr Leu Asp Phe His Thr Asn Thr Leu Tyr Trp Cys Asp Ala Tyr
             740                 745                 750        
 Tyr Asp His Ile Glu Lys Val Phe Leu Asn Gly Thr His Arg Lys Ile
         755                 760                 765            
 Val Tyr Ser Gly Arg Glu Leu Asn His Pro Phe Gly Leu Ser His His
     770                 775                 780                
 Gly Asn Tyr Val Phe Trp Thr Asp Tyr Met Asn Gly Ser Ile Phe Gln
 785                 790                 795                 800
 Leu Asp Leu Ile Thr Ser Glu Val Thr Leu Leu Arg His Glu Arg Pro
                 805                 810                 815    
 Pro Leu Phe Gly Leu Gln Ile Tyr Asp Pro Arg Lys Gln Gln Gly Asp
             820                 825                 830        
 Asn Met Cys Arg Val Asn Asn Gly Gly Cys Ser Thr Leu Cys Leu Ala
         835                 840                 845            
 Ile Pro Gly Gly Arg Val Cys Ala Cys Ala Asp Asn Gln Leu Leu Asp
     850                 855                 860                
 Glu Asn Gly Thr Thr Cys Thr Phe Asn Pro Gly Glu Ala Leu Pro His
 865                 870                 875                 880
 Ile Cys Lys Ala Gly Glu Phe Arg Cys Lys Asn Arg His Cys Ile Gln
                 885                 890                 895    
 Ala Arg Trp Lys Cys Asp Gly Asp Asp Asp Cys Leu Asp Gly Ser Asp
             900                 905                 910        
 Glu Asp Ser Val Asn Cys Phe Asn His Ser Cys Pro Asp Asp Gln Phe
         915                 920                 925            
 Lys Cys Gln Asn Asn Arg Cys Ile Pro Lys Arg Trp Leu Cys Asp Gly
     930                 935                 940                
 Ala Asn Asp Cys Gly Ser Asn Glu Asp Glu Ser Asn Gln Thr Cys Thr
 945                 950                 955                 960
 Ala Arg Thr Cys Gln Val Asp Gln Phe Ser Cys Gly Asn Gly Arg Cys
                 965                 970                 975    
 Ile Pro Arg Ala Trp Leu Cys Asp Arg Glu Asp Asp Cys Gly Asp Gln
             980                 985                 990        
 Thr Asp Glu Met Ala Ser Cys Glu Phe Pro Thr Cys Glu Pro Leu Thr
         995                1000                1005            
 Gln Phe Val Cys Lys Ser Gly Arg Cys Ile Ser Ser Lys Trp His Cys
    1010                1015                1020                
 Asp Ser Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu Val Gly Cys Val
1025                1030                1035                1040
 His Ser Cys Phe Asp Asn Gln Phe Arg Cys Ser Ser Gly Arg Cys Ile
                1045                1050                1055    
 Pro Gly His Trp Ala Cys Asp Gly Asp Asn Asp Cys Gly Asp Phe Ser
            1060                1065                1070        
 Asp Glu Ala Gln Ile Asn Cys Thr Lys Glu Glu Ile His Ser Pro Ala
        1075                1080                1085            
 Gly Cys Asn Gly Asn Glu Phe Gln Cys His Pro Asp Gly Asn Cys Val
    1090                1095                1100                
 Pro Asp Leu Trp Arg Cys Asp Gly Glu Lys Asp Cys Glu Asp Gly Ser
1105                1110                1115                1120
 Asp Glu Lys Gly Cys Asn Gly Thr Ile Arg Leu Cys Asp His Lys Thr
                1125                1130                1135    
 Lys Phe Ser Cys Trp Ser Thr Gly Arg Cys Ile Asn Lys Ala Trp Val
            1140                1145                1150        
 Cys Asp Gly Asp Ile Asp Cys Glu Asp Gln Ser Asp Glu Asp Asp Cys
        1155                1160                1165            
 Asp Ser Phe Leu Cys Gly Pro Pro Lys His Pro Cys Ala Asn Asp Thr
    1170                1175                1180                
 Ser Val Cys Leu Gln Pro Glu Lys Leu Cys Asn Gly Lys Lys Asp Cys
1185                1190                1195                1200
 Pro Asp Gly Ser Asp Glu Gly Tyr Leu Cys Asp Glu Cys Ser Leu Asn
                1205                1210                1215    
 Asn Gly Gly Cys Ser Asn His Cys Ser Val Val Pro Gly Arg Gly Ile
            1220                1225                1230        
 Val Cys Ser Cys Pro Glu Gly Leu Gln Leu Asn Lys Asp Asn Lys Thr
        1235                1240                1245            
 Cys Glu Ile Val Asp Tyr Cys Ser Asn His Leu Lys Cys Ser Gln Val
    1250                1255                1260                
 Cys Glu Gln His Lys His Thr Val Lys Cys Ser Cys Tyr Glu Gly Trp
1265                1270                1275                1280
 Lys Leu Asp Val Asp Gly Glu Ser Cys Thr Ser Val Asp Pro Phe Glu
                1285                1290                1295    
 Ala Phe Ile Ile Phe Ser Ile Arg His Glu Ile Arg Arg Ile Asp Leu
            1300                1305                1310        
 His Lys Arg Asp Tyr Ser Leu Leu Val Pro Gly Leu Arg Asn Thr Ile
        1315                1320                1325            
 Ala Leu Asp Phe His Phe Asn Gln Ser Leu Leu Tyr Trp Thr Asp Val
    1330                1335                1340                
 Val Glu Asp Arg Ile Tyr Arg Gly Lys Leu Ser Glu Ser Gly Gly Val
1345                1350                1355                1360
 Ser Ala Ile Glu Val Val Val Glu His Gly Leu Ala Thr Pro Glu Gly
                1365                1370                1375    
 Leu Thr Val Asp Trp Ile Ala Gly Asn Ile Tyr Trp Ile Asp Ser Asn
            1380                1385                1390        
 Leu Asp Gln Ile Glu Val Ala Lys Leu Asp Gly Ser Leu Arg Thr Thr
        1395                1400                1405            
 Leu Ile Ala Gly Ala Met Glu His Pro Arg Ala Ile Ala Leu Asp Pro
    1410                1415                1420                
 Arg Tyr Gly Ile Leu Phe Trp Thr Asp Trp Asp Ala Asn Phe Pro Arg
1425                1430                1435                1440
 Ile Glu Ser Ala Ser Met Ser Gly Ala Gly Arg Lys Thr Ile Tyr Lys
                1445                1450                1455    
 Asp Met Lys Thr Gly Ala Trp Pro Asn Gly Leu Thr Val Asp His Phe
            1460                1465                1470        
 Glu Lys Arg Ile Val Trp Thr Asp Ala Arg Ser Asp Ala Ile Tyr Ser
        1475                1480                1485            
 Ala Leu Tyr Asp Gly Thr Asn Met Ile Glu Ile Ile Arg Gly His Glu
    1490                1495                1500                
 Tyr Leu Ser His Pro Phe Ala Val Ser Leu Tyr Gly Ser Glu Val Tyr
1505                1510                1515                1520
 Trp Thr Asp Trp Arg Thr Asn Thr Leu Ser Lys Ala Asn Lys Trp Thr
                1525                1530                1535    
 Gly Gln Asn Val Ser Val Ile Gln Lys Thr Ser Ala Gln Pro Phe Asp
            1540                1545                1550        
 Leu Gln Ile Tyr His Pro Ser Arg Gln Pro Gln Ala Pro Asn Pro Cys
        1555                1560                1565            
 Ala Ala Asn Asp Gly Lys Gly Pro Cys Ser His Met Cys Leu Ile Asn
    1570                1575                1580                
 His Asn Arg Ser Ala Ala Cys Ala Cys Pro His Leu Met Lys Leu Ser
1585                1590                1595                1600
 Ser Asp Lys Lys Thr Cys Tyr Glu Met Lys Lys Phe Leu Leu Tyr Ala
                1605                1610                1615    
 Arg Arg Ser Glu Ile Arg Gly Val Asp Ile Asp Asn Pro Tyr Phe Asn
            1620                1625                1630        
 Phe Ile Thr Ala Phe Thr Val Pro Asp Ile Asp Asp Val Thr Val Ile
        1635                1640                1645            
 Asp Phe Asp Ala Ser Glu Glu Arg Leu Tyr Trp Thr Asp Ile Lys Thr
    1650                1655                1660                
 Gln Thr Ile Lys Arg Ala Phe Ile Asn Gly Thr Gly Leu Glu Thr Val
1665                1670                1675                1680
 Ile Ser Arg Asp Ile Gln Ser Ile Arg Gly Leu Ala Val Asp Trp Val
                1685                1690                1695    
 Ser Arg Asn Leu Tyr Trp Ile Ser Ser Glu Phe Asp Glu Thr Gln Ile
            1700                1705                1710        
 Asn Val Ala Arg Leu Asp Gly Ser Leu Lys Thr Ser Ile Ile His Gly
        1715                1720                1725            
 Ile Asp Lys Pro Gln Cys Leu Ala Ala His Pro Val Arg Gly Lys Leu
    1730                1735                1740                
 Tyr Trp Thr Asp Gly Asn Thr Ile Asn Met Ala Asn Met Asp Gly Ser
1745                1750                1755                1760
 Asn Ser Lys Ile Leu Phe Gln Asn Gln Lys Glu Pro Val Gly Leu Ser
                1765                1770                1775    
 Ile Asp Tyr Val Glu Asn Lys Leu Tyr Trp Ile Ser Ser Gly Asn Gly
            1780                1785                1790        
 Thr Ile Asn Arg Cys Asn Leu Asp Gly Gly Asn Leu Glu Val Ile Glu
        1795                1800                1805            
 Ser Met Lys Glu Glu Leu Thr Lys Ala Thr Ala Leu Thr Ile Met Asp
    1810                1815                1820                
 Lys Lys Leu Trp Trp Ala Asp Gln Asn Leu Ala Gln Leu Gly Thr Cys
1825                1830                1835                1840
 Ser Lys Arg Asp Gly Arg Asn Pro Thr Ile Leu Arg Asn Lys Thr Ser
                1845                1850                1855    
 Gly Val Val His Met Lys Val Tyr Asp Lys Glu Ala Gln Gln Gly Ser
            1860                1865                1870        
 Asn Ser Cys Gln Leu Asn Asn Gly Gly Cys Ser Gln Leu Cys Leu Pro
        1875                1880                1885            
 Thr Ser Glu Thr Thr Arg Thr Cys Met Cys Thr Val Gly Tyr Tyr Leu
    1890                1895                1900                
 Gln Lys Asn Arg Met Ser Cys Gln Gly Ile Glu Ser Phe Leu Met Tyr
1905                1910                1915                1920
 Ser Val His Glu Gly Ile Arg Gly Ile Pro Leu Glu Pro Ser Asp Lys
                1925                1930                1935    
 Met Asp Ala Leu Met Pro Ile Ser Gly Thr Ser Phe Ala Val Gly Ile
            1940                1945                1950        
 Asp Phe His Ala Glu Asn Asp Thr Ile Tyr Trp Thr Asp Met Gly Phe
        1955                1960                1965            
 Asn Lys Ile Ser Arg Ala Lys Arg Asp Gln Thr Trp Lys Glu Asp Ile
    1970                1975                1980                
 Ile Thr Asn Gly Leu Gly Arg Val Glu Gly Ile Ala Val Asp Trp Ile
1985                1990                1995                2000
 Ala Gly Asn Ile Tyr Trp Thr Asp His Gly Phe Asn Leu Ile Glu Val
                2005                2010                2015    
 Ala Arg Leu Asn Gly Ser Phe Arg Tyr Val Ile Ile Ser Gln Gly Leu
            2020                2025                2030        
 Asp Gln Pro Arg Ser Ile Ala Val His Pro Glu Lys Gly Leu Leu Phe
        2035                2040                2045            
 Trp Thr Glu Trp Gly Gln Met Pro Cys Ile Gly Lys Ala Arg Leu Asp
    2050                2055                2060                
 Gly Ser Glu Lys Val Val Leu Val Ser Met Gly Ile Ala Trp Pro Asn
2065                2070                2075                2080
 Gly Ile Ser Ile Asp Tyr Glu Glu Asn Lys Leu Tyr Trp Cys Asp Ala
                2085                2090                2095    
 Arg Thr Asp Lys Ile Glu Arg Ile Asp Leu Glu Thr Gly Gly Asn Arg
            2100                2105                2110        
 Glu Met Val Leu Ser Gly Ser Asn Val Asp Met Phe Ser Val Ala Val
        2115                2120                2125            
 Phe Gly Ala Tyr Ile Tyr Trp Ser Asp Arg Ala His Ala Asn Gly Ser
    2130                2135                2140                
 Val Arg Arg Gly His Lys Asn Asp Ala Thr Glu Thr Ile Thr Met Arg
2145                2150                2155                2160
 Thr Gly Leu Gly Val Asn Leu Lys Glu Val Lys Ile Phe Asn Arg Val
                2165                2170                2175    
 Arg Glu Lys Gly Thr Asn Val Cys Ala Arg Asp Asn Gly Gly Cys Lys
            2180                2185                2190        
 Gln Leu Cys Leu Tyr Arg Gly Asn Ser Arg Arg Thr Cys Ala Cys Ala
        2195                2200                2205            
 His Gly Tyr Leu Ala Glu Asp Gly Val Thr Cys Leu Arg His Glu Gly
    2210                2215                2220                
 Tyr Leu Leu Tyr Ser Gly Arg Thr Ile Leu Lys Ser Ile His Leu Ser
2225                2230                2235                2240
 Asp Glu Thr Asn Leu Asn Ser Pro Ile Arg Pro Tyr Glu Asn Pro Arg
                2245                2250                2255    
 Tyr Phe Lys Asn Val Ile Ala Leu Ala Phe Asp Tyr Asn Gln Arg Arg
            2260                2265                2270        
 Lys Gly Thr Asn Arg Ile Phe Tyr Ser Asp Ala His Phe Gly Asn Ile
        2275                2280                2285            
 Gln Leu Ile Lys Asp Asn Trp Glu Asp Arg Gln Val Ile Val Glu Asn
    2290                2295                2300                
 Val Gly Ser Val Glu Gly Leu Ala Tyr His Arg Ala Trp Asp Thr Leu
2305                2310                2315                2320
 Tyr Trp Thr Ser Ser Thr Thr Ser Ser Ile Thr Arg His Thr Val Asp
                2325                2330                2335    
 Gln Thr Arg Pro Gly Ala Phe Asp Arg Glu Ala Val Ile Thr Met Ser
            2340                2345                2350        
 Glu Asp Asp His Pro His Val Leu Ala Leu Asp Glu Cys Gln Asn Leu
        2355                2360                2365            
 Met Phe Trp Thr Asn Trp Asn Glu Gln His Pro Ser Ile Met Arg Ser
    2370                2375                2380                
 Thr Leu Thr Gly Lys Asn Ala Gln Val Val Val Ser Thr Asp Ile Leu
2385                2390                2395                2400
 Thr Pro Asn Gly Leu Thr Ile Asp Tyr Arg Ala Glu Lys Leu Tyr Phe
                2405                2410                2415    
 Ser Asp Gly Ser Leu Gly Lys Ile Glu Arg Cys Glu Tyr Asp Gly Ser
            2420                2425                2430        
 Gln Arg His Val Ile Val Lys Ser Gly Pro Gly Thr Phe Leu Ser Leu
        2435                2440                2445            
 Ala Val Tyr Asp Asn Tyr Ile Phe Trp Ser Asp Trp Gly Arg Arg Ala
    2450                2455                2460                
 Ile Leu Arg Ser Asn Lys Tyr Thr Gly Gly Asp Thr Lys Ile Leu Arg
2465                2470                2475                2480
 Ser Asp Ile Pro His Gln Pro Met Gly Ile Ile Ala Val Ala Asn Asp
                2485                2490                2495    
 Thr Asn Ser Cys Glu Leu Ser Pro Cys Ala Leu Leu Asn Gly Gly Cys
            2500                2505                2510        
 His Asp Leu Cys Leu Leu Thr Pro Asn Gly Arg Val Asn Cys Ser Cys
        2515                2520                2525            
 Arg Gly Asp Arg Ile Leu Leu Glu Asp Asn Arg Cys Val Thr Lys Asn
    2530                2535                2540                
 Ser Ser Cys Asn Ala Tyr Ser Glu Phe Glu Cys Gly Asn Gly Glu Cys
2545                2550                2555                2560
 Ile Asp Tyr Gln Leu Thr Cys Asp Gly Ile Pro His Cys Lys Asp Lys
                2565                2570                2575    
 Ser Asp Glu Lys Leu Leu Tyr Cys Glu Asn Arg Ser Cys Arg Arg Gly
            2580                2585                2590        
 Phe Lys Pro Cys Tyr Asn Arg Arg Cys Ile Pro His Gly Lys Leu Cys
        2595                2600                2605            
 Asp Gly Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu Leu Asp Cys Lys
    2610                2615                2620                
 Val Ser Thr Cys Ala Thr Val Glu Phe Arg Cys Ala Asp Gly Thr Cys
2625                2630                2635                2640
 Ile Pro Arg Ser Ala Arg Cys Asn Gln Asn Ile Asp Cys Ala Asp Ala
                2645                2650                2655    
 Ser Asp Glu Lys Asn Cys Asn Asn Thr Asp Cys Thr His Phe Tyr Lys
            2660                2665                2670        
 Leu Gly Val Lys Thr Thr Gly Phe Ile Arg Cys Asn Ser Thr Ser Leu
        2675                2680                2685            
 Cys Val Leu Pro Thr Trp Ile Cys Asp Gly Ser Asn Asp Cys Gly Asp
    2690                2695                2700                
 Tyr Ser Asp Glu Leu Lys Cys Pro Val Gln Asn Lys His Lys Cys Glu
2705                2710                2715                2720
 Glu Asn Tyr Phe Ser Cys Pro Ser Gly Arg Cys Ile Leu Asn Thr Trp
                2725                2730                2735    
 Ile Cys Asp Gly Gln Lys Asp Cys Glu Asp Gly Arg Asp Glu Phe His
            2740                2745                2750        
 Cys Asp Ser Ser Cys Ser Trp Asn Gln Phe Ala Cys Ser Ala Gln Lys
        2755                2760                2765            
 Cys Ile Ser Lys His Trp Ile Cys Asp Gly Glu Asp Asp Cys Gly Asp
    2770                2775                2780                
 Gly Leu Asp Glu Ser Asp Ser Ile Cys Gly Ala Ile Thr Cys Ala Ala
2785                2790                2795                2800
 Asp Met Phe Ser Cys Gln Gly Ser Arg Ala Cys Val Pro Arg His Trp
                2805                2810                2815    
 Leu Cys Asp Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Leu Ser
            2820                2825                2830        
 Thr Ala Gly Cys Ala Pro Asn Asn Thr Cys Asp Glu Asn Ala Phe Met
        2835                2840                2845            
 Cys His Asn Lys Val Cys Ile Pro Lys Gln Phe Val Cys Asp His Asp
    2850                2855                2860                
 Asp Asp Cys Gly Asp Gly Ser Asp Glu Ser Pro Gln Cys Gly Tyr Arg
2865                2870                2875                2880
 Gln Cys Gly Thr Glu Glu Phe Ser Cys Ala Asp Gly Arg Cys Leu Leu
                2885                2890                2895    
 Asn Thr Gln Trp Gln Cys Asp Gly Asp Phe Asp Cys Pro Asp His Ser
            2900                2905                2910        
 Asp Glu Ala Pro Leu Asn Pro Lys Cys Lys Ser Ala Glu Gln Ser Cys
        2915                2920                2925            
 Asn Ser Ser Phe Phe Met Cys Lys Asn Gly Arg Cys Ile Pro Ser Gly
    2930                2935                2940                
 Gly Leu Cys Asp Asn Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu Arg
2945                2950                2955                2960
 Asn Cys His Ile Asn Glu Cys Leu Ser Lys Lys Val Ser Gly Cys Ser
                2965                2970                2975    
 Gln Asp Cys Gln Asp Leu Pro Val Ser Tyr Lys Cys Lys Cys Trp Pro
            2980                2985                2990        
 Gly Phe Gln Leu Lys Asp Asp Gly Lys Thr Cys Val Asp Ile Asp Glu
        2995                3000                3005            
 Cys Ser Ser Gly Phe Pro Cys Ser Gln Gln Cys Ile Asn Thr Tyr Gly
    3010                3015                3020                
 Thr Tyr Lys Cys Leu Cys Thr Asp Gly Tyr Glu Ile Gln Pro Asp Asn
3025                3030                3035                3040
 Pro Asn Gly Cys Lys Ser Leu Ser Asp Glu Glu Pro Phe Leu Ile Leu
                3045                3050                3055    
 Ala Asp His His Glu Ile Arg Lys Ile Ser Thr Asp Gly Ser Asn Tyr
            3060                3065                3070        
 Thr Leu Leu Lys Gln Gly Leu Asn Asn Val Ile Ala Ile Asp Phe Asp
        3075                3080                3085            
 Tyr Arg Glu Glu Phe Ile Tyr Trp Ile Asp Ser Ser Arg Pro Asn Gly
    3090                3095                3100                
 Ser Arg Ile Asn Arg Met Cys Leu Asn Gly Ser Asp Ile Lys Val Val
3105                3110                3115                3120
 His Asn Thr Ala Val Pro Asn Ala Leu Ala Val Asp Trp Ile Gly Lys
                3125                3130                3135    
 Asn Leu Tyr Trp Ser Asp Thr Glu Lys Arg Ile Ile Glu Val Ser Lys
            3140                3145                3150        
 Leu Asn Gly Leu Tyr Pro Thr Ile Leu Val Ser Lys Arg Leu Lys Phe
        3155                3160                3165            
 Pro Arg Asp Leu Ser Leu Asp Pro Gln Ala Gly Tyr Leu Tyr Trp Ile
    3170                3175                3180                
 Asp Cys Cys Glu Tyr Pro His Ile Gly Arg Val Gly Met Asp Gly Thr
3185                3190                3195                3200
 Asn Gln Ser Val Val Ile Glu Thr Lys Ile Ser Arg Pro Met Ala Leu
                3205                3210                3215    
 Thr Ile Asp Tyr Val Asn Arg Arg Leu Tyr Trp Ala Asp Glu Asn His
            3220                3225                3230        
 Ile Glu Phe Ser Asn Met Asp Gly Ser His Arg His Lys Val Pro Asn
        3235                3240                3245            
 Gln Asp Ile Pro Gly Val Ile Ala Leu Thr Leu Phe Glu Asp Tyr Ile
    3250                3255                3260                
 Tyr Trp Thr Asp Gly Lys Thr Lys Ser Leu Ser Arg Ala His Lys Thr
3265                3270                3275                3280
 Ser Gly Ala Asp Arg Leu Ser Leu Ile Tyr Ser Trp His Ala Ile Thr
                3285                3290                3295    
 Asp Ile Gln Val Tyr His Ser Tyr Arg Gln Pro Asp Val Ser Lys His
            3300                3305                3310        
 Leu Cys Met Ile Asn Asn Gly Gly Cys Ser His Leu Cys Leu Leu Ala
        3315                3320                3325            
 Pro Gly Lys Thr His Thr Cys Ala Cys Pro Thr Asn Phe Tyr Leu Ala
    3330                3335                3340                
 Ala Asp Asn Arg Thr Cys Leu Ser Asn Cys Thr Ala Ser Gln Phe Arg
3345                3350                3355                3360
 Cys Lys Thr Asp Lys Cys Ile Pro Phe Trp Trp Lys Cys Asp Thr Val
                3365                3370                3375    
 Asp Asp Cys Gly Asp Gly Ser Asp Glu Pro Asp Asp Cys Pro Glu Phe
            3380                3385                3390        
 Arg Cys Gln Pro Gly Arg Phe Gln Cys Gly Thr Gly Leu Cys Ala Leu
        3395                3400                3405            
 Pro Ala Phe Ile Cys Asp Gly Glu Asn Asp Cys Gly Asp Asn Ser Asp
    3410                3415                3420                
 Glu Leu Asn Cys Asp Thr His Val Cys Leu Ser Gly Gln Phe Lys Cys
3425                3430                3435                3440
 Thr Lys Asn Gln Lys Cys Ile Pro Val Asn Leu Arg Cys Asn Gly Gln
                3445                3450                3455    
 Asp Asp Cys Gly Asp Glu Glu Asp Glu Arg Asp Cys Pro Glu Asn Ser
            3460                3465                3470        
 Cys Ser Pro Asp Tyr Phe Gln Cys Lys Thr Thr Lys His Cys Ile Ser
        3475                3480                3485            
 Lys Leu Trp Val Cys Asp Glu Asp Pro Asp Cys Ala Asp Ala Ser Asp
    3490                3495                3500                
 Glu Ala Asn Cys Asp Lys Lys Thr Cys Gly Pro His Glu Phe Gln Cys
3505                3510                3515                3520
 Lys Asn Asn Asn Cys Ile Pro Asp His Trp Arg Cys Asp Ser Gln Asn
                3525                3530                3535    
 Asp Cys Ser Asp Asn Ser Asp Glu Glu Asn Cys Lys Pro Gln Thr Cys
            3540                3545                3550        
 Thr Leu Lys Asp Phe Leu Cys Ala Asn Gly Asp Cys Val Ser Ser Arg
        3555                3560                3565            
 Phe Trp Cys Asp Gly Asp Phe Asp Cys Ala Asp Gly Ser Asp Glu Arg
    3570                3575                3580                
 Asn Cys Glu Thr Ser Cys Ser Lys Asp Gln Phe Arg Cys Ser Asn Gly
3585                3590                3595                3600
 Gln Cys Ile Pro Ala Lys Trp Lys Cys Asp Gly His Glu Asp Cys Lys
                3605                3610                3615    
 Tyr Gly Glu Asp Glu Lys Ser Cys Glu Pro Ala Ser Pro Thr Cys Ser
            3620                3625                3630        
 Ser Arg Glu Tyr Ile Cys Ala Ser Asp Gly Cys Ile Ser Ala Ser Leu
        3635                3640                3645            
 Lys Cys Asn Gly Glu Tyr Asp Cys Ala Asp Gly Ser Asp Glu Met Asp
    3650                3655                3660                
 Cys Val Thr Glu Cys Lys Glu Asp Gln Phe Arg Cys Lys Asn Lys Ala
3665                3670                3675                3680
 His Cys Ile Pro Ile Arg Trp Leu Cys Asp Gly Ile His Asp Cys Val
                3685                3690                3695    
 Asp Gly Ser Asp Glu Glu Asn Cys Glu Arg Gly Gly Asn Ile Cys Arg
            3700                3705                3710        
 Ala Asp Glu Phe Leu Cys Asn Asn Ser Leu Cys Lys Leu His Phe Trp
        3715                3720                3725            
 Val Cys Asp Gly Glu Asp Asp Cys Gly Asp Asn Ser Asp Glu Ala Pro
    3730                3735                3740                
 Asp Met Cys Val Lys Phe Leu Cys Pro Ser Thr Arg Pro His Arg Cys
3745                3750                3755                3760
 Arg Asn Asn Arg Ile Cys Leu Gln Ser Glu Gln Met Cys Asn Gly Ile
                3765                3770                3775    
 Asp Glu Cys Gly Asp Asn Ser Asp Glu Asp His Cys Gly Gly Lys Leu
            3780                3785                3790        
 Thr Tyr Lys Ala Arg Pro Cys Lys Lys Asp Glu Phe Ala Cys Ser Asn
        3795                3800                3805            
 Lys Lys Cys Ile Pro Met Asp Leu Gln Cys Asp Arg Leu Asp Asp Cys
    3810                3815                3820                
 Gly Asp Gly Ser Asp Glu Gln Gly Cys Arg Ile Ala Pro Thr Glu Tyr
3825                3830                3835                3840
 Thr Cys Glu Asp Asn Val Asn Pro Cys Gly Asp Asp Ala Tyr Cys Asn
                3845                3850                3855    
 Gln Ile Lys Thr Ser Val Phe Cys Arg Cys Lys Pro Gly Phe Gln Arg
            3860                3865                3870        
 Asn Met Lys Asn Arg Gln Cys Glu Asp Leu Asn Glu Cys Leu Val Phe
        3875                3880                3885            
 Gly Thr Cys Ser His Gln Cys Ile Asn Val Glu Gly Ser Tyr Lys Cys
    3890                3895                3900                
 Val Cys Asp Gln Asn Phe Gln Glu Arg Asn Asn Thr Cys Ile Ala Glu
3905                3910                3915                3920
 Gly Ser Glu Asp Gln Val Leu Tyr Ile Ala Asn Asp Thr Asp Ile Leu
                3925                3930                3935    
 Gly Phe Ile Tyr Pro Phe Asn Tyr Ser Gly Asp His Gln Gln Ile Ser
            3940                3945                3950        
 His Ile Glu His Asn Ser Arg Ile Thr Gly Met Asp Val Tyr Tyr Gln
        3955                3960                3965            
 Arg Asp Met Ile Ile Trp Ser Thr Gln Phe Asn Pro Gly Gly Ile Phe
    3970                3975                3980                
 Tyr Lys Arg Ile His Gly Arg Glu Lys Arg Gln Ala Asn Ser Gly Leu
3985                3990                3995                4000
 Ile Cys Pro Glu Phe Lys Arg Pro Arg Asp Ile Ala Val Asp Trp Val
                4005                4010                4015    
 Ala Gly Asn Ile Tyr Trp Thr Asp His Ser Arg Met His Trp Phe Ser
            4020                4025                4030        
 Tyr Tyr Thr Thr His Trp Thr Ser Leu Arg Tyr Ser Ile Asn Val Gly
        4035                4040                4045            
 Gln Leu Asn Gly Pro Asn Cys Thr Arg Leu Leu Thr Asn Met Ala Gly
    4050                4055                4060                
 Glu Pro Tyr Ala Ile Ala Val Asn Pro Lys Arg Gly Met Met Tyr Trp
4065                4070                4075                4080
 Thr Val Val Gly Asp His Ser His Ile Glu Glu Ala Ala Met Asp Gly
                4085                4090                4095    
 Thr Leu Arg Arg Ile Leu Val Gln Lys Asn Leu Gln Arg Pro Thr Gly
            4100                4105                4110        
 Leu Ala Val Asp Tyr Phe Ser Glu Arg Ile Tyr Trp Ala Asp Phe Glu
        4115                4120                4125            
 Leu Ser Ile Ile Gly Ser Val Leu Tyr Asp Gly Ser Asn Ser Val Val
    4130                4135                4140                
 Ser Val Ser Ser Lys Gln Gly Leu Leu His Pro His Arg Ile Asp Ile
4145                4150                4155                4160
 Phe Glu Asp Tyr Ile Tyr Gly Ala Gly Pro Lys Asn Gly Val Phe Arg
                4165                4170                4175    
 Val Gln Lys Phe Gly His Gly Ser Val Glu Tyr Leu Ala Leu Asn Ile
            4180                4185                4190        
 Asp Lys Thr Lys Gly Val Leu Ile Ser His Arg Tyr Lys Gln Leu Asp
        4195                4200                4205            
 Leu Pro Asn Pro Cys Leu Asp Leu Ala Cys Glu Phe Leu Cys Leu Leu
    4210                4215                4220                
 Asn Pro Ser Gly Ala Thr Cys Val Cys Pro Glu Gly Lys Tyr Leu Ile
4225                4230                4235                4240
 Asn Gly Thr Cys Asn Asp Asp Ser Leu Leu Asp Asp Ser Cys Lys Leu
                4245                4250                4255    
 Thr Cys Glu Asn Gly Gly Arg Cys Ile Leu Asn Glu Lys Gly Asp Leu
            4260                4265                4270        
 Arg Cys His Cys Trp Pro Ser Tyr Ser Gly Glu Arg Cys Glu Val Asn
        4275                4280                4285            
 His Cys Ser Asn Tyr Cys Gln Asn Gly Gly Thr Cys Val Pro Ser Val
    4290                4295                4300                
 Leu Gly Arg Pro Thr Cys Ser Cys Ala Leu Gly Phe Thr Gly Pro Asn
4305                4310                4315                4320
 Cys Gly Lys Thr Val Cys Glu Asp Phe Cys Gln Asn Gly Gly Thr Cys
                4325                4330                4335    
 Ile Val Thr Ala Gly Asn Gln Pro Tyr Cys His Cys Gln Pro Glu Tyr
            4340                4345                4350        
 Thr Gly Asp Arg Cys Gln Tyr Tyr Val Cys His His Tyr Cys Val Asn
        4355                4360                4365            
 Ser Glu Ser Cys Thr Ile Gly Asp Asp Gly Ser Leu Glu Cys Val Cys
    4370                4375                4380                
 Pro Thr Arg Tyr Glu Gly Pro Lys Cys Glu Val Asp Lys Cys Val Arg
4385                4390                4395                4400
 Cys His Gly Gly His Cys Ile Ile Asn Lys Asp Ser Glu Asp Ile Phe
                4405                4410                4415    
 Cys Asn Cys Thr Asn Gly Lys Ile Ala Ser Ser Cys Gln Leu Cys Asp
            4420                4425                4430        
 Gly Tyr Cys Tyr Asn Gly Gly Thr Cys Gln Leu Asp Pro Glu Thr Asn
        4435                4440                4445            
 Val Pro Val Cys Leu Cys Ser Thr Asn Trp Ser Gly Thr Gln Cys Glu
    4450                4455                4460                
 Arg Pro Ala Pro Lys Ser Ser Lys Ser Asp His Ile Ser Thr Arg Ser
4465                4470                4475                4480
 Ile Ala Ile Ile Val Pro Leu Val Leu Leu Val Thr Leu Ile Thr Thr
                4485                4490                4495    
 Leu Val Ile Gly Leu Val Leu Cys Lys Arg Lys Arg Arg Thr Lys Thr
            4500                4505                4510        
 Ile Arg Arg Gln Pro Ile Ile Asn Gly Gly Ile Asn Val Glu Ile Gly
        4515                4520                4525            
 Asn Pro Ser Tyr Asn Met Tyr Glu Val Asp His Asp His Asn Asp Gly
    4530                4535                4540                
 Gly Leu Leu Asp Pro Gly Phe Met Ile Asp Pro Thr Lys Ala Arg Tyr
4545                4550                4555                4560
 Ile Gly Gly Gly Pro Ser Ala Phe Lys Leu Pro His Thr Ala Pro Pro
                4565                4570                4575    
 Ile Tyr Leu Asn Ser Asp Leu Lys Gly Pro Leu Thr Ala Gly Pro Thr
            4580                4585                4590        
 Asn Tyr Ser Asn Pro Val Tyr Ala Lys Leu Tyr Met Asp Gly Gln Asn
        4595                4600                4605            
 Cys Arg Asn Ser Leu Gly Ser Val Asp Glu Arg Lys Glu Leu Leu Pro
    4610                4615                4620                
 Lys Lys Ile Glu Ile Gly Ile Arg Glu Thr Val Ala
4625                4630                4635    



      <210> 712
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 712
 Met Thr Pro Leu Asp Ser Arg Leu Gln Ala Ala Pro Ala Ala Ala Ala
   1               5                  10                  15    
 Ala Ala Gly Pro Lys Val Pro Pro Ser Ser Leu Gln Arg Arg Leu Pro
              20                  25                  30        
 Tyr Arg Ala Thr Thr Met Ser Glu Phe Leu Leu Ala Leu Leu Thr Leu
          35                  40                  45            
 Ser Gly Leu Leu Pro Ile Ala Arg Val Leu Thr Val Gly Ala Asp Arg
      50                  55                  60                
 Asp Gln Gln Leu Cys Asp Pro Gly Glu Phe Leu Cys His Asp His Val
  65                  70                  75                  80
 Thr Cys Val Ser Gln Ser Trp Leu Cys Asp Gly Asp Pro Asp Cys Pro
                  85                  90                  95    
 Asp Asp Ser Asp Glu Ser Leu Asp Thr Cys Pro Glu Glu Val Glu Ile
             100                 105                 110        
 Lys Cys Pro Leu Asn His Ile Ala Cys Leu Gly Thr Asn Lys Cys Val
         115                 120                 125            
 His Leu Ser Gln Leu Cys Asn Gly Val Leu Asp Cys Pro Asp Gly Tyr
     130                 135                 140                
 Asp Glu Gly Val His Cys Gln Glu Leu Leu Ser Asn Cys Gln Gln Leu
 145                 150                 155                 160
 Asn Cys Gln Tyr Lys Cys Thr Met Val Arg Asn Ser Thr Arg Cys Tyr
                 165                 170                 175    
 Cys Glu Asp Gly Phe Glu Ile Thr Glu Asp Gly Ile Ile Lys Lys Ala
             180                 185                 190        





      <210> 713
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 713
 Met Gly Ala Lys Asp Pro Ser Ile Glu Pro Ser Ser Ser Ile Pro His
   1               5                  10                  15    
 Pro Val Gly Cys Arg Gly Ser Gly Ser Met Thr Thr Glu Thr Phe Val
              20                  25                  30        
 Lys Asp Ile Lys Pro Gly Leu Lys Asn Leu Asn Leu Ile Phe Ile Val
          35                  40                  45            
 Leu Glu Thr Gly Arg Val Thr Lys Thr Lys Asp Gly His Glu Val Arg
      50                  55                  60                
 Thr Cys Lys Val Ala Asp Lys Thr Gly Ser Ile Asn Ile Ser Val Trp
  65                  70                  75                  80
 Asp Asp Val Gly Asn Leu Ile Gln Pro Gly Asp Ile Ile Arg Leu Thr
                  85                  90                  95    
 Lys Gly Tyr Ala Ser Val Phe Lys Gly Cys Leu Thr Leu Tyr Thr Gly
             100                 105                 110        
 Arg Gly Gly Asp Leu Gln Lys Ile Gly Glu Phe Cys Met Val Tyr Ser
         115                 120                 125            
 Glu Val Pro Asn Phe Ser Glu Pro Asn Pro Glu Tyr Ser Thr Gln Gln
     130                 135                 140                
 Ala Pro Asn Lys Ala Val Gln Asn Asp Ser Asn Pro Ser Ala Ser Gln
 145                 150                 155                 160
 Pro Thr Thr Gly Pro Ser Ala Ala Ser Pro Ala Ser Glu Asn Gln Asn
                 165                 170                 175    
 Gly Asn Gly Leu Ser Ala Pro Pro Gly Pro Gly Gly Gly Pro His Pro
             180                 185                 190        
 Pro His Thr Pro Ser His Pro Pro Ser Thr Arg Ile Thr Arg Ser Gln
         195                 200                 205            
 Pro Asn His Thr Pro Ala Gly Pro Pro Gly Pro Ser Ser Asn Pro Val
     210                 215                 220                
 Ser Asn Gly Lys Glu Thr Arg Arg Ser Ser Lys Arg
 225                 230                 235    



      <210> 714
      <211> 1749
      <212> PRT
      <213> Homo sapiens


      <400> 714
 Met Asp Leu Ala Pro Asp Arg Ala Thr Gly Arg Pro Trp Leu Pro Leu
   1               5                  10                  15    
 His Thr Leu Ser Val Ser Gln Leu Leu Arg Val Phe Trp Leu Leu Ser
              20                  25                  30        
 Leu Leu Pro Gly Gln Ala Trp Val His Gly Ala Glu Pro Arg Gln Val
          35                  40                  45            
 Phe Gln Val Leu Glu Glu Gln Pro Pro Gly Thr Leu Val Gly Thr Ile
      50                  55                  60                
 Gln Thr Arg Pro Gly Phe Thr Tyr Arg Leu Ser Glu Ser His Ala Leu
  65                  70                  75                  80
 Phe Ala Ile Asn Ser Ser Thr Gly Ala Leu Tyr Thr Thr Ser Thr Ile
                  85                  90                  95    
 Asp Arg Glu Ser Leu Pro Ser Asp Val Ile Asn Leu Val Val Leu Ser
             100                 105                 110        
 Ser Ala Pro Thr Tyr Pro Thr Glu Val Arg Val Leu Val Arg Asp Leu
         115                 120                 125            
 Asn Asp Asn Ala Pro Val Phe Pro Asp Pro Ser Ile Val Val Thr Phe
     130                 135                 140                
 Lys Glu Asp Ser Ser Ser Gly Arg Gln Val Ile Leu Asp Thr Ala Thr
 145                 150                 155                 160
 Asp Ser Asp Ile Gly Ser Asn Gly Val Asp His Arg Ser Tyr Arg Ile
                 165                 170                 175    
 Ile Arg Gly Asn Glu Ala Gly Arg Phe Arg Leu Asp Ile Thr Leu Asn
             180                 185                 190        
 Pro Ser Gly Glu Gly Ala Phe Leu His Leu Val Ser Lys Gly Gly Leu
         195                 200                 205            
 Asp Arg Glu Val Thr Pro Gln Tyr Gln Leu Leu Val Glu Val Glu Asp
     210                 215                 220                
 Lys Gly Glu Pro Lys Arg Arg Gly Tyr Leu Gln Val Asn Val Thr Val
 225                 230                 235                 240
 Gln Asp Ile Asn Asp Asn Pro Pro Val Phe Gly Ser Ser His Tyr Gln
                 245                 250                 255    
 Ala Gly Val Pro Glu Asp Ala Val Val Gly Ser Ser Val Leu Gln Val
             260                 265                 270        
 Ala Ala Ala Asp Ala Asp Glu Gly Thr Asn Ala Asp Ile Arg Tyr Arg
         275                 280                 285            
 Leu Gln Asp Glu Gly Thr Pro Phe Gln Met Asp Pro Glu Thr Gly Leu
     290                 295                 300                
 Ile Thr Val Arg Glu Pro Leu Asp Phe Glu Ala Arg Arg Gln Tyr Ser
 305                 310                 315                 320
 Leu Thr Val Gln Ala Met Asp Arg Gly Val Pro Ser Leu Thr Gly Arg
                 325                 330                 335    
 Ala Glu Ala Leu Ile Gln Leu Leu Asp Val Asn Asp Asn Asp Pro Val
             340                 345                 350        
 Val Lys Phe Arg Tyr Phe Pro Ala Thr Ser Arg Tyr Ala Ser Val Asp
         355                 360                 365            
 Glu Asn Ala Gln Val Gly Thr Val Val Ala Leu Leu Thr Val Thr Asp
     370                 375                 380                
 Ala Asp Ser Pro Ala Ala Asn Gly Asn Ile Ser Val Gln Ile Leu Gly
 385                 390                 395                 400
 Gly Asn Glu Gln Arg His Phe Glu Val Gln Ser Ser Lys Val Pro Asn
                 405                 410                 415    
 Leu Ser Leu Ile Lys Val Ala Ser Ala Leu Asp Arg Glu Arg Ile Pro
             420                 425                 430        
 Ser Tyr Asn Leu Thr Val Ser Val Ser Asp Asn Tyr Gly Ala Pro Pro
         435                 440                 445            
 Gly Ala Ala Val Leu Ala Arg Ser Ser Val Ala Ser Leu Val Ile Phe
     450                 455                 460                
 Val Asn Asp Ile Asn Asp His Pro Pro Val Phe Ser Gln Gln Val Tyr
 465                 470                 475                 480
 Arg Val Asn Leu Ser Glu Glu Ala Pro Pro Gly Ser Tyr Val Ser Gly
                 485                 490                 495    
 Ile Ser Ala Thr Asp Gly Asp Ser Gly Leu Asn Ala Asn Leu Arg Tyr
             500                 505                 510        
 Ser Ile Val Ser Gly Asn Gly Leu Gly Trp Phe His Ile Ser Glu His
         515                 520                 525            
 Ser Gly Leu Val Thr Thr Gly Ser Ser Gly Gly Leu Asp Arg Glu Leu
     530                 535                 540                
 Ala Ser Gln Ile Val Leu Asn Ile Ser Ala Arg Asp Gln Gly Val His
 545                 550                 555                 560
 Pro Lys Val Ser Tyr Ala Gln Leu Val Val Thr Leu Leu Asp Val Asn
                 565                 570                 575    
 Asp Glu Lys Pro Val Phe Ser Gln Pro Glu Gly Tyr Asp Val Ser Val
             580                 585                 590        
 Val Glu Asn Ala Pro Thr Gly Thr Glu Leu Leu Met Leu Arg Ala Thr
         595                 600                 605            
 Asp Gly Asp Leu Gly Asp Asn Gly Thr Val Arg Phe Ser Leu Gln Glu
     610                 615                 620                
 Ala Glu Thr Asp Arg Arg Ser Phe Arg Leu Asp Pro Val Ser Gly Arg
 625                 630                 635                 640
 Leu Ser Thr Ile Ser Ser Leu Asp Arg Glu Glu Gln Ala Phe Tyr Ser
                 645                 650                 655    
 Leu Leu Val Leu Ala Thr Asp Leu Gly Ser Pro Pro Gln Ser Ser Met
             660                 665                 670        
 Ala Arg Ile Asn Val Ser Leu Leu Asp Ile Asn Asp Asn Ser Pro Val
         675                 680                 685            
 Phe Tyr Pro Val Gln Tyr Phe Ala His Ile Lys Glu Asn Glu Pro Gly
     690                 695                 700                
 Gly Ser Tyr Ile Thr Thr Val Ser Ala Thr Asp Pro Asp Leu Gly Thr
 705                 710                 715                 720
 Asn Gly Thr Val Lys Tyr Ser Ile Ser Ala Gly Asp Arg Ser Arg Phe
                 725                 730                 735    
 Gln Val Asn Ala Gln Ser Gly Val Ile Ser Thr Arg Met Ala Leu Asp
             740                 745                 750        
 Arg Glu Glu Lys Thr Ala Tyr Gln Leu Gln Ile Val Ala Thr Asp Gly
         755                 760                 765            
 Gly Asn Leu Gln Ser Pro Asn Gln Ala Ile Val Thr Ile Thr Val Leu
     770                 775                 780                
 Asp Thr Gln Asp Asn Pro Pro Val Phe Ser Gln Val Ala Tyr Ser Phe
 785                 790                 795                 800
 Val Val Phe Glu Asn Val Ala Leu Gly Tyr His Val Gly Ser Val Ser
                 805                 810                 815    
 Ala Ser Thr Met Asp Leu Asn Ser Asn Ile Ser Tyr Leu Ile Thr Thr
             820                 825                 830        
 Gly Asp Gln Lys Gly Met Phe Ala Ile Asn Gln Val Thr Gly Gln Leu
         835                 840                 845            
 Thr Thr Ala Asn Val Ile Asp Arg Glu Glu Gln Ser Phe Tyr Gln Leu
     850                 855                 860                
 Lys Val Val Ala Ser Gly Gly Thr Val Thr Gly Asp Thr Met Val Asn
 865                 870                 875                 880
 Ile Thr Val Lys Asp Leu Asn Asp Asn Ser Pro His Phe Leu Gln Ala
                 885                 890                 895    
 Ile Glu Ser Val Asn Val Val Glu Asn Trp Gln Ala Gly His Ser Ile
             900                 905                 910        
 Phe Gln Ala Lys Ala Val Asp Pro Asp Glu Gly Val Asn Gly Met Val
         915                 920                 925            
 Leu Tyr Ser Leu Lys Gln Asn Pro Lys Asn Leu Phe Ala Ile Asn Glu
     930                 935                 940                
 Lys Asn Gly Thr Ile Ser Leu Leu Gly Pro Leu Asp Val His Ala Gly
 945                 950                 955                 960
 Ser Tyr Gln Ile Glu Ile Leu Ala Ser Asp Met Gly Val Pro Gln Leu
                 965                 970                 975    
 Ser Ser Ser Val Ile Leu Thr Val Tyr Val His Asp Val Asn Asp Asn
             980                 985                 990        
 Ser Pro Val Phe Asp Gln Leu Ser Tyr Glu Val Thr Leu Ser Glu Ser
         995                1000                1005            
 Glu Pro Val Asn Ser Arg Phe Phe Lys Val Gln Ala Ser Asp Lys Asp
    1010                1015                1020                
 Ser Gly Ala Asn Gly Glu Ile Ala Tyr Thr Ile Ala Glu Gly Asn Thr
1025                1030                1035                1040
 Gly Asp Ala Phe Gly Ile Phe Pro Asp Gly Gln Leu Tyr Ile Lys Ser
                1045                1050                1055    
 Glu Leu Asp Arg Glu Leu Gln Asp Arg Tyr Val Leu Met Val Val Ala
            1060                1065                1070        
 Ser Asp Arg Ala Val Glu Pro Leu Ser Ala Thr Val Asn Val Thr Val
        1075                1080                1085            
 Ile Leu Glu Asp Val Asn Asp Asn Arg Pro Leu Phe Asn Ser Thr Asn
    1090                1095                1100                
 Tyr Thr Phe Tyr Phe Glu Glu Glu Gln Arg Ala Gly Ser Phe Val Gly
1105                1110                1115                1120
 Lys Val Ser Ala Val Asp Lys Asp Phe Gly Pro Asn Gly Glu Val Arg
                1125                1130                1135    
 Tyr Ser Phe Glu Met Val Gln Pro Asp Phe Glu Leu His Ala Ile Ser
            1140                1145                1150        
 Gly Glu Ile Thr Asn Thr His Gln Phe Asp Arg Glu Ser Leu Met Arg
        1155                1160                1165            
 Arg Arg Gly Thr Ala Val Phe Ser Phe Thr Val Ile Ala Thr Asp Gln
    1170                1175                1180                
 Gly Ile Pro Gln Pro Leu Lys Asp Gln Ala Thr Val His Val Tyr Met
1185                1190                1195                1200
 Lys Asp Ile Asn Asp Asn Ala Pro Lys Phe Leu Lys Asp Phe Tyr Gln
                1205                1210                1215    
 Ala Thr Ile Ser Glu Ser Ala Ala Asn Leu Thr Gln Val Leu Arg Val
            1220                1225                1230        
 Ser Ala Ser Asp Val Asp Glu Gly Asn Asn Gly Leu Ile His Tyr Ser
        1235                1240                1245            
 Ile Ile Lys Gly Asn Glu Glu Arg Gln Phe Ala Ile Asp Ser Thr Ser
    1250                1255                1260                
 Gly Gln Val Thr Leu Ile Gly Lys Leu Asp Tyr Glu Ala Thr Pro Ala
1265                1270                1275                1280
 Tyr Ser Leu Val Ile Gln Ala Val Asp Ser Gly Thr Ile Pro Leu Asn
                1285                1290                1295    
 Ser Thr Cys Thr Leu Asn Ile Asp Ile Leu Asp Glu Asn Asp Asn Thr
            1300                1305                1310        
 Pro Ser Phe Pro Lys Ser Thr Leu Phe Val Asp Val Leu Glu Asn Met
        1315                1320                1325            
 Arg Ile Gly Glu Leu Val Ser Ser Val Thr Ala Thr Asp Ser Asp Ser
    1330                1335                1340                
 Gly Asp Asn Ala Asp Leu Tyr Tyr Ser Ile Thr Gly Thr Asn Asn His
1345                1350                1355                1360
 Gly Thr Phe Ser Ile Ser Pro Asn Thr Gly Ser Ile Phe Leu Ala Lys
                1365                1370                1375    
 Lys Leu Asp Phe Glu Thr Gln Ser Leu Tyr Lys Leu Asn Ile Thr Ala
            1380                1385                1390        
 Lys Asp Gln Gly Arg Pro Pro Arg Ser Ser Thr Met Ser Val Val Ile
        1395                1400                1405            
 His Val Arg Asp Phe Asn Asp Asn Pro Pro Ser Phe Pro Pro Gly Asp
    1410                1415                1420                
 Ile Phe Lys Ser Ile Val Glu Asn Ile Pro Ile Gly Thr Ser Val Ile
1425                1430                1435                1440
 Ser Val Thr Ala His Asp Pro Asp Ala Asp Ile Asn Gly Gln Leu Ser
                1445                1450                1455    
 Tyr Thr Ile Ile Gln Gln Met Pro Arg Gly Asn His Phe Thr Ile Asp
            1460                1465                1470        
 Glu Val Lys Gly Thr Ile Tyr Thr Asn Ala Glu Ile Asp Arg Glu Phe
        1475                1480                1485            
 Ala Asn Leu Phe Glu Leu Thr Val Lys Ala Asn Asp Gln Ala Val Pro
    1490                1495                1500                
 Ile Glu Thr Arg Arg Tyr Ala Leu Lys Asn Val Thr Ile Leu Val Thr
1505                1510                1515                1520
 Asp Leu Asn Asp Asn Val Pro Met Phe Ile Ser Gln Asn Ala Leu Ala
                1525                1530                1535    
 Ala Asp Pro Ser Ala Val Ile Gly Ser Val Leu Thr Thr Ile Met Ala
            1540                1545                1550        
 Ala Asp Pro Asp Glu Gly Ala Asn Gly Glu Ile Glu Tyr Glu Ile Ile
        1555                1560                1565            
 Asn Gly Asp Thr Asp Thr Phe Ile Val Asp Arg Tyr Ser Gly Asp Leu
    1570                1575                1580                
 Arg Val Ala Ser Ala Leu Val Pro Ser Gln Leu Ile Tyr Asn Leu Ile
1585                1590                1595                1600
 Val Ser Ala Thr Asp Leu Gly Pro Glu Arg Arg Lys Ser Thr Thr Glu
                1605                1610                1615    
 Leu Thr Ile Ile Leu Gln Gly Leu Asp Gly Pro Val Phe Thr Gln Pro
            1620                1625                1630        
 Lys Tyr Ile Thr Ile Leu Lys Glu Gly Glu Pro Ile Gly Thr Asn Val
        1635                1640                1645            
 Ile Ser Ile Glu Ala Ala Ser Pro Arg Gly Ser Glu Ala Pro Val Glu
    1650                1655                1660                
 Tyr Tyr Ile Val Ser Val Arg Cys Glu Glu Lys Thr Val Gly Arg Leu
1665                1670                1675                1680
 Phe Thr Ile Gly Arg His Thr Gly Ile Ile Gln Thr Ala Ala Ile Leu
                1685                1690                1695    
 Asp Arg Glu Gln Gly Ala Cys Leu Tyr Leu Val Asp Val Tyr Ala Ile
            1700                1705                1710        
 Glu Lys Ser Thr Ala Phe Pro Arg Thr Gln Arg Ala Glu Ala Pro Gln
        1715                1720                1725            
 Arg His Ser Ser Val Ser Gln Pro Lys Thr Gln Thr Ser Asn Val Val
    1730                1735                1740                
 Cys Asp Thr Trp Gln
1745                



      <210> 715
      <211> 1729
      <212> PRT
      <213> Homo sapiens


      <400> 715
 Met Asp Leu Ala Pro Asp Arg Ala Thr Gly Arg Pro Trp Leu Pro Leu
   1               5                  10                  15    
 His Thr Leu Ser Val Ser Gln Leu Leu Arg Val Phe Trp Leu Leu Ser
              20                  25                  30        
 Leu Leu Pro Gly Gln Ala Trp Val His Gly Ala Glu Pro Arg Gln Val
          35                  40                  45            
 Phe Gln Val Leu Glu Glu Gln Pro Pro Gly Thr Leu Val Gly Thr Ile
      50                  55                  60                
 Gln Thr Arg Pro Gly Phe Thr Tyr Arg Leu Ser Glu Ser His Ala Leu
  65                  70                  75                  80
 Phe Ala Ile Asn Ser Ser Thr Gly Ala Leu Tyr Thr Thr Ser Thr Ile
                  85                  90                  95    
 Asp Arg Glu Ser Leu Pro Ser Asp Val Ile Asn Leu Val Val Leu Ser
             100                 105                 110        
 Ser Ala Pro Thr Tyr Pro Thr Glu Val Arg Val Leu Val Arg Asp Leu
         115                 120                 125            
 Asn Asp Asn Ala Pro Val Phe Pro Asp Pro Ser Ile Val Val Thr Phe
     130                 135                 140                
 Lys Glu Asp Ser Ser Ser Gly Arg Gln Val Ile Leu Asp Thr Ala Thr
 145                 150                 155                 160
 Asp Ser Asp Ile Gly Ser Asn Gly Val Asp His Arg Ser Tyr Arg Ile
                 165                 170                 175    
 Ile Arg Gly Asn Glu Ala Gly Arg Phe Arg Leu Asp Ile Thr Leu Asn
             180                 185                 190        
 Pro Ser Gly Glu Gly Ala Phe Leu His Leu Val Ser Lys Gly Gly Leu
         195                 200                 205            
 Asp Arg Glu Val Thr Pro Gln Tyr Gln Leu Leu Val Glu Val Glu Asp
     210                 215                 220                
 Lys Gly Glu Pro Lys Arg Arg Gly Tyr Leu Gln Val Asn Val Thr Val
 225                 230                 235                 240
 Gln Asp Ile Asn Asp Asn Pro Pro Val Phe Gly Ser Ser His Tyr Gln
                 245                 250                 255    
 Ala Gly Val Pro Glu Asp Ala Val Val Gly Ser Ser Val Leu Gln Val
             260                 265                 270        
 Ala Ala Ala Asp Ala Asp Glu Gly Thr Asn Ala Asp Ile Arg Tyr Arg
         275                 280                 285            
 Leu Gln Asp Glu Gly Thr Pro Phe Gln Met Asp Pro Glu Thr Gly Leu
     290                 295                 300                
 Ile Thr Val Arg Glu Pro Leu Asp Phe Glu Ala Arg Arg Gln Tyr Ser
 305                 310                 315                 320
 Leu Thr Val Gln Ala Met Asp Arg Gly Val Pro Ser Leu Thr Gly Arg
                 325                 330                 335    
 Ala Glu Ala Leu Ile Gln Leu Leu Asp Val Asn Asp Asn Asp Pro Val
             340                 345                 350        
 Val Lys Phe Arg Tyr Phe Pro Ala Thr Ser Arg Tyr Ala Ser Val Asp
         355                 360                 365            
 Glu Asn Ala Gln Val Gly Thr Val Val Ala Leu Leu Thr Val Thr Asp
     370                 375                 380                
 Ala Asp Ser Pro Ala Ala Asn Gly Asn Ile Ser Val Gln Ile Leu Gly
 385                 390                 395                 400
 Gly Asn Glu Gln Arg His Phe Glu Val Gln Ser Ser Lys Val Pro Asn
                 405                 410                 415    
 Leu Ser Leu Ile Lys Val Ala Ser Ala Leu Asp Arg Glu Arg Ile Pro
             420                 425                 430        
 Ser Tyr Asn Leu Thr Val Ser Val Ser Asp Asn Tyr Gly Ala Pro Pro
         435                 440                 445            
 Gly Ala Ala Val Gln Ala Arg Ser Ser Val Ala Ser Leu Val Ile Phe
     450                 455                 460                
 Val Asn Asp Ile Asn Asp His Pro Pro Val Phe Ser Gln Gln Val Tyr
 465                 470                 475                 480
 Arg Val Asn Leu Ser Glu Glu Ala Pro Pro Gly Ser Tyr Val Ser Gly
                 485                 490                 495    
 Ile Ser Ala Thr Asp Gly Asp Ser Gly Leu Asn Ala Asn Leu Arg Tyr
             500                 505                 510        
 Ser Ile Val Ser Gly Asn Gly Leu Gly Trp Phe His Ile Ser Glu His
         515                 520                 525            
 Ser Gly Leu Val Thr Thr Gly Ser Ser Gly Gly Leu Asp Arg Glu Leu
     530                 535                 540                
 Ala Ser Gln Ile Val Leu Asn Ile Ser Ala Arg Asp Gln Gly Val His
 545                 550                 555                 560
 Pro Lys Val Ser Tyr Ala Gln Leu Val Val Thr Leu Leu Asp Val Asn
                 565                 570                 575    
 Asp Glu Lys Pro Val Phe Ser Gln Pro Glu Gly Tyr Asp Val Ser Val
             580                 585                 590        
 Val Glu Asn Ala Pro Thr Gly Thr Glu Leu Leu Met Leu Arg Ala Thr
         595                 600                 605            
 Asp Gly Asp Leu Gly Asp Asn Gly Thr Val Arg Phe Ser Leu Gln Glu
     610                 615                 620                
 Ala Glu Thr Asp Arg Arg Ser Phe Arg Leu Asp Pro Val Ser Gly Arg
 625                 630                 635                 640
 Leu Ser Thr Ile Ser Ser Leu Asp Arg Glu Glu Gln Ala Phe Tyr Ser
                 645                 650                 655    
 Leu Leu Val Leu Ala Thr Asp Leu Gly Ser Pro Pro Gln Ser Ser Met
             660                 665                 670        
 Ala Arg Ile Asn Val Ser Leu Leu Asp Ile Asn Asp Asn Ser Pro Val
         675                 680                 685            
 Phe Tyr Pro Val Gln Tyr Phe Ala His Ile Lys Glu Asn Glu Pro Gly
     690                 695                 700                
 Gly Ser Tyr Ile Thr Thr Val Ser Ala Thr Asp Pro Asp Leu Gly Thr
 705                 710                 715                 720
 Asn Gly Thr Val Lys Tyr Ser Ile Ser Ala Gly Asp Arg Ser Arg Phe
                 725                 730                 735    
 Gln Val Asn Ala Gln Ser Gly Val Ile Ser Thr Arg Met Ala Leu Asp
             740                 745                 750        
 Arg Glu Glu Lys Thr Ala Tyr Gln Leu Gln Ile Val Ala Thr Asp Gly
         755                 760                 765            
 Gly Asn Leu Gln Ser Pro Asn Gln Ala Ile Val Thr Ile Thr Val Leu
     770                 775                 780                
 Asp Thr Gln Asp Asn Pro Pro Val Phe Ser Gln Val Ala Tyr Ser Phe
 785                 790                 795                 800
 Val Val Phe Glu Asn Val Ala Leu Gly Tyr His Val Gly Ser Val Ser
                 805                 810                 815    
 Ala Ser Thr Met Asp Leu Asn Ser Asn Ile Ser Tyr Leu Ile Thr Thr
             820                 825                 830        
 Gly Asp Gln Lys Gly Met Phe Ala Ile Asn Gln Val Thr Gly Gln Leu
         835                 840                 845            
 Thr Thr Ala Asn Val Ile Asp Arg Glu Glu Gln Ser Phe Tyr Gln Leu
     850                 855                 860                
 Lys Val Val Ala Ser Gly Gly Thr Val Thr Gly Asp Thr Met Val Asn
 865                 870                 875                 880
 Ile Thr Val Lys Asp Leu Asn Asp Asn Ser Pro His Phe Leu Gln Ala
                 885                 890                 895    
 Ile Glu Ser Val Asn Val Val Glu Asn Trp Gln Ala Gly His Ser Ile
             900                 905                 910        
 Phe Gln Ala Lys Ala Val Asp Pro Asp Glu Gly Val Asn Gly Met Val
         915                 920                 925            
 Leu Tyr Ser Leu Lys Gln Asn Pro Lys Asn Leu Phe Ala Ile Asn Glu
     930                 935                 940                
 Lys Asn Gly Thr Ile Ser Leu Leu Gly Pro Leu Asp Val His Ala Gly
 945                 950                 955                 960
 Ser Tyr Gln Ile Glu Ile Leu Ala Ser Asp Met Gly Val Pro Gln Leu
                 965                 970                 975    
 Ser Ser Ser Val Ile Leu Thr Val Tyr Val His Asp Val Asn Asp Asn
             980                 985                 990        
 Ser Pro Val Phe Asp Gln Leu Ser Tyr Glu Val Thr Leu Ser Glu Ser
         995                1000                1005            
 Glu Pro Val Asn Ser Arg Phe Phe Lys Val Gln Ala Ser Asp Lys Asp
    1010                1015                1020                
 Ser Gly Ala Asn Gly Glu Ile Ala Tyr Thr Ile Ala Glu Gly Asn Thr
1025                1030                1035                1040
 Gly Asp Ala Phe Gly Ile Phe Pro Asp Gly Gln Leu Tyr Ile Lys Ser
                1045                1050                1055    
 Glu Leu Asp Arg Glu Leu Gln Asp Arg Tyr Val Leu Met Val Val Ala
            1060                1065                1070        
 Ser Asp Arg Ala Val Glu Pro Leu Ser Ala Thr Val Asn Val Thr Val
        1075                1080                1085            
 Ile Leu Glu Asp Val Asn Asp Asn Arg Pro Leu Phe Asn Ser Thr Asn
    1090                1095                1100                
 Tyr Thr Phe Tyr Phe Glu Glu Glu Gln Arg Ala Gly Ser Phe Val Gly
1105                1110                1115                1120
 Lys Val Ser Ala Val Asp Lys Asp Phe Gly Pro Asn Gly Glu Val Arg
                1125                1130                1135    
 Tyr Ser Phe Glu Met Val Gln Pro Asp Phe Glu Leu His Ala Ile Ser
            1140                1145                1150        
 Gly Glu Ile Thr Asn Thr His Gln Phe Asp Arg Glu Ser Leu Met Arg
        1155                1160                1165            
 Arg Arg Gly Thr Ala Val Phe Ser Phe Thr Val Ile Ala Thr Asp Gln
    1170                1175                1180                
 Gly Ile Pro Gln Pro Leu Lys Asp Gln Ala Thr Val His Val Tyr Met
1185                1190                1195                1200
 Lys Asp Ile Asn Asp Asn Ala Pro Lys Phe Leu Lys Asp Phe Tyr Gln
                1205                1210                1215    
 Ala Thr Ile Ser Glu Ser Ala Ala Asn Leu Thr Gln Val Leu Arg Val
            1220                1225                1230        
 Ser Ala Ser Asp Val Asp Glu Gly Asn Asn Gly Leu Ile His Tyr Ser
        1235                1240                1245            
 Ile Ile Lys Gly Asn Glu Glu Arg Gln Phe Ala Ile Asp Ser Thr Ser
    1250                1255                1260                
 Gly Gln Val Thr Leu Ile Gly Lys Leu Asp Tyr Glu Ala Thr Pro Ala
1265                1270                1275                1280
 Tyr Ser Leu Val Ile Gln Ala Val Asp Ser Gly Thr Ile Pro Leu Asn
                1285                1290                1295    
 Ser Thr Cys Thr Leu Asn Ile Asp Ile Leu Asp Glu Asn Asp Asn Thr
            1300                1305                1310        
 Pro Ser Phe Pro Lys Ser Thr Leu Phe Val Asp Val Leu Glu Asn Met
        1315                1320                1325            
 Arg Ile Gly Glu Leu Val Ser Ser Val Thr Ala Thr Asp Ser Asp Ser
    1330                1335                1340                
 Gly Asp Asn Ala Asp Leu Tyr Tyr Ser Ile Thr Gly Thr Asn Asn His
1345                1350                1355                1360
 Gly Thr Phe Ser Ile Ser Pro Asn Thr Gly Ser Ile Phe Leu Ala Lys
                1365                1370                1375    
 Lys Leu Asp Phe Glu Thr Gln Ser Leu Tyr Lys Leu Asn Ile Thr Ala
            1380                1385                1390        
 Lys Asp Gln Gly Arg Pro Pro Arg Ser Ser Thr Met Ser Val Val Ile
        1395                1400                1405            
 His Val Arg Asp Phe Asn Asp Asn Pro Pro Ser Phe Pro Pro Gly Asp
    1410                1415                1420                
 Ile Phe Lys Ser Ile Val Glu Asn Ile Pro Ile Gly Thr Ser Val Ile
1425                1430                1435                1440
 Ser Val Thr Ala His Asp Pro Asp Ala Asp Ile Asn Gly Gln Leu Ser
                1445                1450                1455    
 Tyr Thr Ile Ile Gln Gln Met Pro Arg Gly Asn His Phe Thr Ile Asp
            1460                1465                1470        
 Glu Val Lys Gly Thr Ile Tyr Thr Asn Ala Glu Ile Asp Arg Glu Phe
        1475                1480                1485            
 Ala Asn Leu Phe Glu Leu Thr Val Lys Ala Asn Asp Gln Ala Val Pro
    1490                1495                1500                
 Ile Glu Thr Arg Arg Tyr Ala Leu Lys Asn Val Thr Ile Leu Val Thr
1505                1510                1515                1520
 Asp Leu Asn Asp Asn Val Pro Met Phe Ile Ser Gln Asn Ala Leu Ala
                1525                1530                1535    
 Ala Asp Pro Ser Ala Val Ile Gly Ser Val Leu Thr Thr Ile Met Ala
            1540                1545                1550        
 Ala Asp Pro Asp Glu Gly Ala Asn Gly Glu Ile Glu Tyr Glu Ile Ile
        1555                1560                1565            
 Asn Gly Asp Thr Asp Thr Phe Ile Val Asp Arg Tyr Ser Gly Asp Leu
    1570                1575                1580                
 Arg Val Ala Ser Ala Leu Val Pro Ser Gln Leu Ile Tyr Asn Leu Ile
1585                1590                1595                1600
 Val Ser Ala Thr Asp Leu Gly Pro Glu Arg Arg Lys Ser Thr Thr Glu
                1605                1610                1615    
 Leu Thr Ile Ile Leu Gln Gly Leu Asp Gly Pro Val Phe Thr Gln Pro
            1620                1625                1630        
 Lys Tyr Ile Thr Ile Leu Lys Glu Gly Glu Pro Ile Gly Thr Asn Val
        1635                1640                1645            
 Ile Ser Ile Glu Ala Ala Ser Pro Arg Gly Ser Glu Ala Pro Val Glu
    1650                1655                1660                
 Tyr Tyr Ile Val Ser Val Arg Cys Glu Glu Lys Thr Val Gly Arg Leu
1665                1670                1675                1680
 Phe Thr Ile Gly Arg His Thr Gly Ile Ile Gln Thr Ala Ala Ile Leu
                1685                1690                1695    
 Asp Arg Glu Gln Gly Ala Cys Leu Tyr Leu Val Asp Val Tyr Ala Ile
            1700                1705                1710        
 Glu Lys Ser Thr Ala Phe Pro Arg Thr Gln Arg Ala Glu Val Met Ile
        1715                1720                1725            
 Leu
    



      <210> 716
      <211> 873
      <212> PRT
      <213> Homo sapiens


      <400> 716
 Met Arg Lys Val Lys Lys Leu Arg Leu Asp Lys Glu Asn Thr Gly Ser
   1               5                  10                  15    
 Trp Arg Ser Phe Ser Leu Asn Ser Glu Gly Ala Glu Arg Met Ala Thr
              20                  25                  30        
 Thr Gly Thr Pro Thr Ala Asp Arg Gly Asp Ala Ala Ala Thr Asp Asp
          35                  40                  45            
 Pro Ala Ala Arg Phe Gln Val Gln Lys His Ser Trp Asp Gly Leu Arg
      50                  55                  60                
 Ser Ile Ile His Gly Ser Arg Lys Tyr Ser Gly Leu Ile Val Asn Lys
  65                  70                  75                  80
 Ala Pro His Asp Phe Gln Phe Val Gln Lys Thr Asp Glu Ser Gly Pro
                  85                  90                  95    
 His Ser His Arg Leu Tyr Tyr Leu Gly Met Pro Tyr Gly Ser Arg Glu
             100                 105                 110        
 Asn Ser Leu Leu Tyr Ser Glu Ile Pro Lys Lys Val Arg Lys Glu Ala
         115                 120                 125            
 Leu Leu Leu Leu Ser Trp Lys Gln Met Leu Asp His Phe Gln Ala Thr
     130                 135                 140                
 Pro His His Gly Val Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg
 145                 150                 155                 160
 Lys Arg Leu Gly Val Phe Gly Ile Thr Ser Tyr Asp Phe His Ser Glu
                 165                 170                 175    
 Ser Gly Leu Phe Leu Phe Gln Ala Ser Asn Ser Leu Phe His Cys Arg
             180                 185                 190        
 Asp Gly Gly Lys Asn Gly Phe Met Val Ser Pro Met Lys Pro Leu Glu
         195                 200                 205            
 Ile Lys Thr Gln Cys Ser Gly Pro Arg Met Asp Pro Lys Ile Cys Pro
     210                 215                 220                
 Ala Asp Pro Ala Phe Phe Ser Phe Ile Asn Asn Ser Asp Leu Trp Val
 225                 230                 235                 240
 Ala Asn Ile Glu Thr Gly Glu Glu Arg Arg Leu Thr Phe Cys His Gln
                 245                 250                 255    
 Gly Leu Ser Asn Val Leu Asp Asp Pro Lys Ser Ala Gly Val Ala Thr
             260                 265                 270        
 Phe Val Ile Gln Glu Glu Phe Asp Arg Phe Thr Gly Tyr Trp Trp Cys
         275                 280                 285            
 Pro Thr Ala Ser Trp Glu Gly Ser Glu Gly Leu Lys Thr Leu Arg Ile
     290                 295                 300                
 Leu Tyr Glu Glu Val Asp Glu Ser Glu Val Glu Val Ile His Val Pro
 305                 310                 315                 320
 Ser Pro Ala Leu Glu Glu Arg Lys Thr Asp Ser Tyr Arg Tyr Pro Arg
                 325                 330                 335    
 Thr Gly Ser Lys Asn Pro Lys Ile Ala Leu Lys Leu Ala Glu Phe Gln
             340                 345                 350        
 Thr Asp Ser Gln Gly Lys Ile Val Ser Thr Gln Glu Lys Glu Leu Val
         355                 360                 365            
 Gln Pro Phe Ser Ser Leu Phe Pro Lys Val Glu Tyr Ile Ala Arg Ala
     370                 375                 380                
 Gly Trp Thr Arg Asp Gly Lys Tyr Ala Trp Ala Met Phe Leu Asp Arg
 385                 390                 395                 400
 Pro Gln Gln Trp Leu Gln Leu Val Leu Leu Pro Pro Ala Leu Phe Ile
                 405                 410                 415    
 Pro Ser Thr Glu Asn Glu Glu Gln Arg Leu Ala Ser Ala Arg Ala Val
             420                 425                 430        
 Pro Arg Asn Val Gln Pro Tyr Val Val Tyr Glu Glu Val Thr Asn Val
         435                 440                 445            
 Trp Ile Asn Val His Asp Ile Phe Tyr Pro Phe Pro Gln Ser Glu Gly
     450                 455                 460                
 Glu Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu Cys Lys Thr Gly Phe
 465                 470                 475                 480
 Cys His Leu Tyr Lys Val Thr Ala Val Leu Lys Ser Gln Gly Tyr Asp
                 485                 490                 495    
 Trp Ser Glu Pro Phe Ser Pro Gly Glu Gly Glu Gln Ser Leu Thr Asn
             500                 505                 510        
 Ala Ile Trp Val Asn Glu Glu Thr Lys Leu Val Tyr Phe Gln Gly Thr
         515                 520                 525            
 Lys Asp Thr Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Glu Ala
     530                 535                 540                
 Ala Gly Glu Ile Val Arg Leu Thr Thr Pro Gly Phe Ser His Ser Cys
 545                 550                 555                 560
 Ser Met Ser Gln Asn Phe Asp Met Phe Val Ser His Tyr Ser Ser Val
                 565                 570                 575    
 Ser Thr Pro Pro Cys Val His Val Tyr Lys Leu Ser Gly Pro Asp Asp
             580                 585                 590        
 Asp Pro Leu His Lys Gln Pro Arg Phe Trp Ala Ser Met Met Glu Ala
         595                 600                 605            
 Ala Lys Ile Phe His Phe His Thr Arg Ser Asp Val Arg Leu Tyr Gly
     610                 615                 620                
 Met Ile Tyr Lys Pro His Ala Leu Gln Pro Gly Lys Lys His Pro Thr
 625                 630                 635                 640
 Val Leu Phe Val Tyr Gly Gly Pro Gln Val Gln Leu Val Asn Asn Ser
                 645                 650                 655    
 Phe Lys Gly Ile Lys Tyr Leu Arg Leu Asn Thr Leu Ala Ser Leu Gly
             660                 665                 670        
 Tyr Ala Val Val Val Ile Asp Gly Arg Gly Ser Cys Gln Arg Gly Leu
         675                 680                 685            
 Arg Phe Glu Gly Ala Leu Lys Asn Gln Met Gly Gln Val Glu Ile Glu
     690                 695                 700                
 Asp Gln Val Glu Gly Leu Gln Phe Val Ala Glu Lys Tyr Gly Phe Ile
 705                 710                 715                 720
 Asp Leu Ser Arg Val Ala Ile His Gly Trp Ser Tyr Gly Gly Phe Leu
                 725                 730                 735    
 Ser Leu Met Gly Leu Ile His Lys Pro Gln Val Phe Lys Val Ala Ile
             740                 745                 750        
 Ala Gly Ala Pro Val Thr Val Trp Met Ala Tyr Asp Thr Gly Tyr Thr
         755                 760                 765            
 Glu Arg Tyr Met Asp Val Pro Glu Asn Asn Gln His Gly Tyr Glu Ala
     770                 775                 780                
 Gly Ser Val Ala Leu His Val Glu Lys Leu Pro Asn Glu Pro Asn Arg
 785                 790                 795                 800
 Leu Leu Ile Leu His Gly Phe Leu Asp Glu Asn Val His Phe Phe His
                 805                 810                 815    
 Thr Asn Phe Leu Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln
             820                 825                 830        
 Leu Gln Val Ala Leu Pro Pro Val Ser Pro Gln Ile Tyr Pro Asn Glu
         835                 840                 845            
 Arg His Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr Glu Val Thr
     850                 855                 860                
 Leu Leu His Phe Leu Gln Glu Tyr Leu
 865                 870            



      <210> 717
      <211> 377
      <212> PRT
      <213> Homo sapiens


      <400> 717
 Met Glu Asp Glu Glu Ile Pro Phe Glu Gln Ser Phe Ser Ile Gly Met
   1               5                  10                  15    
 Ser Gln Ile Arg Ile Pro Lys Gly Gly Pro Ser Thr Gln Lys Ala Tyr
              20                  25                  30        
 Pro Cys Gly Thr Cys Gly Leu Val Leu Lys Asp Ile Leu His Leu Ala
          35                  40                  45            
 Glu His Gln Glu Thr His Pro Gly Gln Lys Pro Tyr Met Cys Val Leu
      50                  55                  60                
 Cys Gly Lys Gln Phe Trp Phe Ser Ala Asn Leu His Gln His Gln Lys
  65                  70                  75                  80
 Gln His Ser Gly Glu Lys Pro Phe Arg Ser Asp Lys Ser Arg Pro Phe
                  85                  90                  95    
 Leu Leu Asn Asn Cys Ala Val Gln Ser Leu Glu Met Ser Phe Val Thr
             100                 105                 110        
 Gly Glu Ala Cys Lys Asp Phe Leu Ala Ser Ser Ser Ile Phe Glu His
         115                 120                 125            
 His Ala Pro His Asn Glu Trp Lys Pro His Ser Asn Thr Lys Cys Glu
     130                 135                 140                
 Glu Ala Ser His Cys Gly Lys Arg His Tyr Lys Cys Ser Glu Cys Gly
 145                 150                 155                 160
 Lys Thr Phe Ser Arg Lys Asp Ser Leu Val Gln His Gln Arg Val His
                 165                 170                 175    
 Thr Gly Glu Arg Pro Tyr Glu Cys Gly Glu Cys Gly Lys Thr Phe Ser
             180                 185                 190        
 Arg Lys Pro Ile Leu Ala Gln His Gln Arg Ile His Thr Gly Glu Met
         195                 200                 205            
 Pro Tyr Glu Cys Gly Ile Cys Gly Lys Val Phe Asn His Ser Ser Asn
     210                 215                 220                
 Leu Ile Val His Gln Arg Val His Thr Gly Ala Arg Pro Tyr Lys Cys
 225                 230                 235                 240
 Ser Glu Cys Gly Lys Ala Tyr Ser His Lys Ser Thr Leu Val Gln His
                 245                 250                 255    
 Glu Ser Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly
             260                 265                 270        
 Lys Tyr Phe Gly His Lys Tyr Arg Leu Ile Lys His Trp Ser Val His
         275                 280                 285            
 Thr Gly Ala Arg Pro Tyr Glu Cys Ile Ala Cys Gly Lys Phe Phe Ser
     290                 295                 300                
 Gln Ser Ser Asp Leu Ile Ala His Gln Arg Val His Asn Gly Glu Lys
 305                 310                 315                 320
 Pro Tyr Val Cys Ser Glu Cys Gly Lys Ala Phe Ser His Lys His Val
                 325                 330                 335    
 Leu Val Gln His His Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys
             340                 345                 350        
 Ser Glu Cys Gly Lys Ala Phe Arg Gln Arg Ala Ser Leu Ile Arg His
         355                 360                 365            
 Trp Lys Ile His Thr Gly Glu Arg Pro
     370                 375        



      <210> 718
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 718
 Met Gly Arg Arg Ser Ser Asp Thr Glu Glu Glu Ser Arg Ser Lys Arg
   1               5                  10                  15    
 Lys Lys Lys His Arg Arg Arg Ser Ser Ser Ser Ser Ser Ser Asp Ser
              20                  25                  30        
 Arg Thr Tyr Ser Arg Lys Lys Gly Gly Arg Lys Ser Arg Ser Lys Ser
          35                  40                  45            
 Arg Ser Trp Ser Arg Asp Leu Gln Pro Arg Ser His Ser Tyr Asp Arg
      50                  55                  60                
 Arg Arg Arg His Arg Ser Ser Ser Ser Ser Ser Tyr Gly Ser Arg Arg
  65                  70                  75                  80
 Lys Arg Ser Arg Ser Arg Ser Arg Gly Arg Gly Lys Ser Tyr Arg Val
                  85                  90                  95    
 Gln Arg Ser Arg Ser Lys Ser Arg Thr Arg Arg Ser Arg Ser Arg Pro
             100                 105                 110        
 Arg Leu Arg Ser His Ser Arg Ser Ser Glu Arg Ser Ser His Arg Arg
         115                 120                 125            
 Thr Arg Ser Arg Ser Arg Asp Arg Glu Arg Arg Lys Gly Arg Asp Lys
     130                 135                 140                
 Glu Lys Arg Glu Lys Gly Glu Asp Lys Gly Lys Asp Lys Glu Tyr Ile
 145                 150                 155                 160
 Thr Ser Asn Val Gly Ile Trp Lys His Gln Ser Trp Ile
                 165                 170            



      <210> 719
      <211> 627
      <212> PRT
      <213> Homo sapiens


      <400> 719
 Met Glu Thr Thr Val Ser Arg Pro Val Leu Ser Pro Thr His Ile Asn
   1               5                  10                  15    
 Ala Thr Ala Ser Glu Thr Phe Thr Val Leu Gln Gln Arg Met Arg Ile
              20                  25                  30        
 Val Glu Glu Gln Thr Ser Ser Leu Arg Asp Asp Leu Ile Met Leu Asp
          35                  40                  45            
 Phe Gly Glu Lys Arg Ser His Val Asn Ser Ile Lys Glu Arg Thr Ser
      50                  55                  60                
 Ser Val Gly Leu Pro Ser Val Ile Pro Asn Ser Thr Arg Arg Val Ser
  65                  70                  75                  80
 Phe Ala Pro Asn Leu Pro Ser Met Lys Thr Ser Gln Asp Ile Gly Asp
                  85                  90                  95    
 Ser Arg Ile Ser Leu Lys Thr Leu Leu Asn Ala Ile Lys Thr Met Glu
             100                 105                 110        
 Gly Arg Leu Glu Gly Lys Ile Glu Ile Leu Ala Ser Arg Pro Leu Ile
         115                 120                 125            
 Asn Asp Glu Ser Pro Asn Phe Leu Lys Gln Asp Ser Val Lys Ser Ile
     130                 135                 140                
 Leu Glu Arg Ser Lys Glu Glu Leu Ser Arg Thr Val Lys Cys Arg Asn
 145                 150                 155                 160
 Ala Ala Leu Lys Glu Ser Gln Lys Leu Lys Glu Asp Leu Glu Ala Val
                 165                 170                 175    
 Glu Asp Arg Glu Asn Lys Lys Ala Arg Asn Gln Ser Leu Leu Thr Val
             180                 185                 190        
 Gly Asn Phe Gln Arg Gln Leu Ala Glu Ala Lys Glu Asp Asn Cys Lys
         195                 200                 205            
 Val Thr Ile Met Leu Glu Asn Val Leu Ala Ser His Ser Lys Met Gln
     210                 215                 220                
 Gly Ala Leu Glu Lys Val Gln Ile Glu Leu Gly Arg Arg Asp Ser Glu
 225                 230                 235                 240
 Ile Ala Gly Leu Lys Lys Glu Arg Asp Leu Asn Gln Gln Arg Val Gln
                 245                 250                 255    
 Lys Leu Glu Ala Glu Val Asp Gln Trp Gln Ala Arg Met Leu Val Met
             260                 265                 270        
 Glu Asp Gln His Asn Ser Glu Ile Glu Ser Leu Gln Lys Ala Leu Gly
         275                 280                 285            
 Val Ala Arg Glu Asp Asn Arg Lys Leu Ala Met Ser Leu Glu Gln Ala
     290                 295                 300                
 Leu Gln Thr Asn Asn His Leu Gln Thr Lys Leu Asp His Ile Gln Glu
 305                 310                 315                 320
 Gln Leu Glu Ser Lys Glu Leu Glu Arg Gln Asn Leu Glu Thr Phe Lys
                 325                 330                 335    
 Asp Arg Met Thr Glu Glu Ser Lys Val Glu Ala Glu Leu His Ala Glu
             340                 345                 350        
 Arg Ile Glu Ala Leu Arg Lys Gln Phe Gln Thr Glu Arg Glu Thr Thr
         355                 360                 365            
 Lys Lys Val Ala Gln Arg Glu Val Ala Glu Leu Lys Lys Ala Leu Asp
     370                 375                 380                
 Glu Ala Asn Phe Arg Ser Val Glu Val Ser Arg Thr Asn Arg Glu Leu
 385                 390                 395                 400
 Arg Gln Lys Leu Ala Glu Leu Glu Lys Ile Leu Glu Ser Asn Lys Glu
                 405                 410                 415    
 Lys Ile Lys Asn Gln Lys Thr Gln Ile Lys Leu His Leu Ser Ala Lys
             420                 425                 430        
 Ala Asn Asn Ala Gln Asn Ile Glu Arg Met Lys Gln Ile Glu Lys Glu
         435                 440                 445            
 Leu Lys Gln Met Glu Leu Ile Lys Asp Gln Tyr Gln Lys Lys Asn Tyr
     450                 455                 460                
 Glu Gln Ser Leu Ser Ile Gln Arg Phe Val Cys Glu Met Thr Asn Leu
 465                 470                 475                 480
 Gln Lys Glu Met Gln Met Leu Ala Lys Ser Gln Tyr Asp Ala Ser Val
                 485                 490                 495    
 Arg Asn Lys Gln Gln Glu Leu His Leu Glu Ala Glu Arg Lys Ile Arg
             500                 505                 510        
 Gln Glu Leu Glu Asn Arg Cys Gln Glu Leu Glu Glu Thr Val Arg His
         515                 520                 525            
 Leu Lys Lys Cys Lys Glu Ala Thr Glu Asn Thr Leu Lys Glu Ala Ser
     530                 535                 540                
 Val Glu Ser Glu Gln Ile Thr Ala Asn Leu Glu Glu Ala His Arg Trp
 545                 550                 555                 560
 Phe Lys His Arg Phe Asp Gly Leu Gln Leu Glu Leu Thr Lys Asn Arg
                 565                 570                 575    
 Leu Gln Arg Pro Ser Gly Glu Asp Arg Trp Gln Glu Lys Asp Gln Asp
             580                 585                 590        
 Val Lys His Asp Val Met Ser Asn Gln Ser Val Leu His Arg Trp Glu
         595                 600                 605            
 Arg Lys Gln Asn Leu Arg Pro Met Pro Lys Lys Tyr His Ser Glu Val
     610                 615                 620                
 Gln Arg Lys
 625        



      <210> 720
      <211> 2537
      <212> PRT
      <213> Homo sapiens


      <400> 720
 Met Ile Thr Glu Ser Thr His Val Glu Ile Leu Ala Asp Gly Gln Met
   1               5                  10                  15    
 Leu His Ile Lys Lys Ala Glu Val Ser Asp Thr Gly Gln Tyr Val Cys
              20                  25                  30        
 Arg Ala Ile Asn Val Ala Gly Arg Asp Asp Lys Asn Phe His Leu Asn
          35                  40                  45            
 Val Tyr Val Pro Pro Ser Ile Glu Gly Pro Glu Arg Glu Val Ile Val
      50                  55                  60                
 Glu Thr Ile Ser Asn Pro Val Thr Leu Thr Cys Asp Ala Thr Gly Ile
  65                  70                  75                  80
 Pro Pro Pro Thr Ile Ala Trp Leu Lys Asn His Lys Arg Ile Glu Asn
                  85                  90                  95    
 Ser Asp Ser Leu Glu Val Arg Ile Leu Ser Gly Gly Ser Lys Leu Gln
             100                 105                 110        
 Ile Ala Arg Ser Gln His Ser Asp Ser Gly Asn Tyr Thr Cys Ile Ala
         115                 120                 125            
 Ser Asn Met Glu Gly Lys Ala Gln Lys Tyr Tyr Phe Leu Ser Ile Gln
     130                 135                 140                
 Val Pro Pro Ser Val Ala Gly Ala Glu Ile Pro Ser Asp Val Ser Val
 145                 150                 155                 160
 Leu Leu Gly Glu Asn Val Glu Leu Val Cys Asn Ala Asn Gly Ile Pro
                 165                 170                 175    
 Thr Pro Leu Ile Gln Trp Leu Lys Asp Gly Lys Pro Ile Ala Ser Gly
             180                 185                 190        
 Glu Thr Glu Arg Ile Arg Val Ser Ala Asn Gly Ser Thr Leu Asn Ile
         195                 200                 205            
 Tyr Gly Ala Leu Thr Ser Asp Thr Gly Lys Tyr Thr Cys Val Ala Thr
     210                 215                 220                
 Asn Pro Ala Gly Glu Glu Asp Arg Ile Phe Asn Leu Asn Val Tyr Val
 225                 230                 235                 240
 Thr Pro Thr Ile Arg Gly Asn Lys Asp Glu Ala Glu Lys Leu Met Thr
                 245                 250                 255    
 Leu Val Asp Thr Ser Ile Asn Ile Glu Cys Arg Ala Thr Gly Thr Pro
             260                 265                 270        
 Pro Pro Gln Ile Asn Trp Leu Lys Asn Gly Leu Pro Leu Pro Leu Ser
         275                 280                 285            
 Ser His Ile Arg Leu Leu Ala Ala Gly Gln Val Ile Arg Ile Val Arg
     290                 295                 300                
 Ala Gln Val Ser Asp Val Ala Val Tyr Thr Cys Val Ala Ser Asn Arg
 305                 310                 315                 320
 Ala Gly Val Asp Asn Lys His Tyr Asn Leu Gln Val Phe Ala Pro Pro
                 325                 330                 335    
 Asn Met Asp Asn Ser Met Gly Thr Glu Glu Ile Thr Val Leu Lys Gly
             340                 345                 350        
 Ser Ser Thr Ser Met Ala Cys Ile Thr Asp Gly Thr Pro Ala Pro Ser
         355                 360                 365            
 Met Ala Trp Leu Arg Asp Gly Gln Pro Leu Gly Leu Asp Ala His Leu
     370                 375                 380                
 Thr Val Ser Thr His Gly Met Val Leu Gln Leu Leu Lys Ala Glu Thr
 385                 390                 395                 400
 Glu Asp Ser Gly Lys Tyr Thr Cys Ile Ala Ser Asn Glu Ala Gly Glu
                 405                 410                 415    
 Val Ser Lys His Phe Ile Leu Lys Val Leu Glu Pro Pro His Ile Asn
             420                 425                 430        
 Gly Ser Glu Glu His Glu Glu Ile Ser Val Ile Val Asn Asn Pro Leu
         435                 440                 445            
 Glu Leu Thr Cys Ile Ala Ser Gly Ile Pro Ala Pro Lys Met Thr Trp
     450                 455                 460                
 Met Lys Asp Gly Arg Pro Leu Pro Gln Thr Asp Gln Val Gln Thr Leu
 465                 470                 475                 480
 Gly Gly Gly Glu Val Leu Arg Ile Ser Thr Ala Gln Val Glu Asp Thr
                 485                 490                 495    
 Gly Arg Tyr Thr Cys Leu Ala Ser Ser Pro Ala Gly Asp Asp Asp Lys
             500                 505                 510        
 Glu Tyr Leu Val Arg Val His Val Pro Pro Asn Ile Ala Gly Thr Asp
         515                 520                 525            
 Glu Pro Arg Asp Ile Thr Val Leu Arg Asn Arg Gln Val Thr Leu Glu
     530                 535                 540                
 Cys Lys Ser Asp Ala Val Pro Pro Pro Val Ile Thr Trp Leu Arg Asn
 545                 550                 555                 560
 Gly Glu Arg Leu Gln Ala Thr Pro Arg Val Arg Ile Leu Ser Gly Gly
                 565                 570                 575    
 Arg Tyr Leu Gln Ile Asn Asn Ala Asp Leu Gly Asp Thr Ala Asn Tyr
             580                 585                 590        
 Thr Cys Val Ala Ser Asn Ile Ala Gly Lys Thr Thr Arg Glu Phe Ile
         595                 600                 605            
 Leu Thr Val Asn Val Pro Pro Asn Ile Lys Gly Gly Pro Gln Ser Leu
     610                 615                 620                
 Val Ile Leu Leu Asn Lys Ser Thr Val Leu Glu Cys Ile Ala Glu Gly
 625                 630                 635                 640
 Val Pro Thr Pro Arg Ile Thr Trp Arg Lys Asp Gly Ala Val Leu Ala
                 645                 650                 655    
 Gly Asn His Ala Arg Tyr Ser Ile Leu Glu Asn Gly Phe Leu His Ile
             660                 665                 670        
 Gln Ser Ala His Val Thr Asp Thr Gly Arg Tyr Leu Cys Met Ala Thr
         675                 680                 685            
 Asn Ala Ala Gly Thr Asp Arg Arg Arg Ile Asp Leu Gln Val His Val
     690                 695                 700                
 Pro Pro Ser Ile Ala Pro Gly Pro Thr Asn Met Thr Val Ile Val Asn
 705                 710                 715                 720
 Val Gln Thr Thr Leu Ala Cys Glu Ala Thr Gly Ile Pro Lys Pro Ser
                 725                 730                 735    
 Ile Asn Trp Arg Lys Asn Gly His Leu Leu Asn Val Asp Gln Asn Gln
             740                 745                 750        
 Asn Ser Tyr Arg Leu Leu Ser Ser Gly Ser Leu Val Ile Ile Ser Pro
         755                 760                 765            
 Ser Val Asp Asp Thr Ala Thr Tyr Glu Cys Thr Val Thr Asn Gly Ala
     770                 775                 780                
 Gly Asp Asp Lys Arg Thr Val Asp Leu Thr Val Gln Val Pro Pro Ser
 785                 790                 795                 800
 Ile Ala Asp Glu Pro Thr Asp Phe Leu Val Thr Lys His Ala Pro Ala
                 805                 810                 815    
 Val Ile Thr Cys Thr Ala Ser Gly Val Pro Phe Pro Ser Ile His Trp
             820                 825                 830        
 Thr Lys Asn Gly Ile Arg Leu Leu Pro Arg Gly Asp Gly Tyr Arg Ile
         835                 840                 845            
 Leu Ser Ser Gly Ala Ile Glu Ile Leu Ala Thr Gln Leu Asn His Ala
     850                 855                 860                
 Gly Arg Tyr Thr Cys Val Ala Arg Asn Ala Ala Gly Ser Ala His Arg
 865                 870                 875                 880
 His Val Thr Leu His Val His Glu Pro Pro Val Ile Gln Pro Gln Pro
                 885                 890                 895    
 Ser Glu Leu His Val Ile Leu Asn Asn Pro Ile Leu Leu Pro Cys Glu
             900                 905                 910        
 Ala Thr Gly Thr Pro Ser Pro Phe Ile Thr Trp Gln Lys Glu Gly Ile
         915                 920                 925            
 Asn Val Asn Thr Ser Gly Arg Asn His Ala Val Leu Pro Ser Gly Gly
     930                 935                 940                
 Leu Gln Ile Ser Arg Ala Val Arg Glu Asp Ala Gly Thr Tyr Met Cys
 945                 950                 955                 960
 Val Ala Gln Asn Pro Ala Gly Thr Ala Leu Gly Lys Ile Lys Leu Asn
                 965                 970                 975    
 Val Gln Val Pro Pro Val Ile Ser Pro His Leu Lys Glu Tyr Val Ile
             980                 985                 990        
 Ala Val Asp Lys Pro Ile Thr Leu Ser Cys Glu Ala Asp Gly Leu Pro
         995                1000                1005            
 Pro Pro Asp Ile Thr Trp His Lys Asp Gly Arg Ala Ile Val Glu Ser
    1010                1015                1020                
 Ile Arg Gln Arg Val Leu Ser Ser Gly Ser Leu Gln Ile Thr Phe Val
1025                1030                1035                1040
 Gln Pro Gly Asp Ala Gly His Tyr Thr Cys Met Ala Ala Asn Val Ala
                1045                1050                1055    
 Gly Ser Ser Ser Thr Ser Thr Lys Leu Thr Val His Val Pro Pro Arg
            1060                1065                1070        
 Ile Arg Ser Thr Glu Gly His Tyr Thr Val Asn Glu Asn Ser Gln Ala
        1075                1080                1085            
 Ile Leu Pro Cys Val Ala Asp Gly Ile Pro Thr Pro Ala Ile Asn Trp
    1090                1095                1100                
 Lys Lys Asp Asn Val Leu Leu Ala Asn Leu Leu Gly Lys Tyr Thr Ala
1105                1110                1115                1120
 Glu Pro Tyr Gly Glu Leu Ile Leu Glu Asn Val Val Leu Glu Asp Ser
                1125                1130                1135    
 Gly Phe Tyr Thr Cys Val Ala Asn Asn Ala Ala Gly Glu Asp Thr His
            1140                1145                1150        
 Thr Val Ser Leu Thr Val His Val Leu Pro Thr Phe Thr Glu Leu Pro
        1155                1160                1165            
 Gly Asp Val Ser Leu Asn Lys Gly Glu Gln Leu Arg Leu Ser Cys Lys
    1170                1175                1180                
 Ala Thr Gly Ile Pro Leu Pro Lys Leu Thr Trp Thr Phe Asn Asn Asn
1185                1190                1195                1200
 Ile Ile Pro Ala His Phe Asp Ser Val Asn Gly His Ser Glu Leu Val
                1205                1210                1215    
 Ile Glu Arg Val Ser Lys Glu Asp Ser Gly Thr Tyr Val Cys Thr Ala
            1220                1225                1230        
 Glu Asn Ser Val Gly Phe Val Lys Ala Ile Gly Phe Val Tyr Val Lys
        1235                1240                1245            
 Glu Pro Pro Val Phe Lys Gly Asp Tyr Pro Ser His Trp Ile Glu Pro
    1250                1255                1260                
 Leu Gly Gly Asn Ala Ile Leu Asn Cys Glu Val Lys Gly Asp Pro Thr
1265                1270                1275                1280
 Pro Thr Ile Gln Trp Asn Arg Lys Gly Val Asp Ile Glu Ile Ser His
                1285                1290                1295    
 Arg Ile Arg Gln Leu Gly Asn Gly Ser Leu Ala Ile Tyr Gly Thr Val
            1300                1305                1310        
 Asn Glu Asp Ala Gly Asp Tyr Thr Cys Val Ala Thr Asn Glu Ala Gly
        1315                1320                1325            
 Val Val Glu Arg Ser Met Ser Leu Thr Leu Gln Ser Pro Pro Ile Ile
    1330                1335                1340                
 Thr Leu Glu Pro Val Glu Thr Val Ile Asn Ala Gly Gly Lys Ile Ile
1345                1350                1355                1360
 Leu Asn Cys Gln Ala Thr Gly Glu Pro Gln Pro Thr Ile Thr Trp Ser
                1365                1370                1375    
 Arg Gln Gly His Ser Ile Ser Trp Asp Asp Arg Val Asn Val Leu Ser
            1380                1385                1390        
 Asn Asn Ser Leu Tyr Ile Ala Asp Ala Gln Lys Glu Asp Thr Ser Glu
        1395                1400                1405            
 Phe Glu Cys Val Ala Arg Asn Leu Met Gly Ser Val Leu Val Arg Val
    1410                1415                1420                
 Pro Val Ile Val Gln Val His Gly Gly Phe Ser Gln Trp Ser Ala Trp
1425                1430                1435                1440
 Arg Ala Cys Ser Val Thr Cys Gly Lys Gly Ile Gln Lys Arg Ser Arg
                1445                1450                1455    
 Leu Cys Asn Gln Pro Leu Pro Ala Asn Gly Gly Lys Pro Cys Gln Gly
            1460                1465                1470        
 Ser Asp Leu Glu Met Arg Asn Cys Gln Asn Lys Pro Cys Pro Val Asp
        1475                1480                1485            
 Gly Ser Trp Ser Glu Trp Ser Leu Trp Glu Glu Cys Thr Arg Ser Cys
    1490                1495                1500                
 Gly Arg Gly Asn Gln Thr Arg Thr Arg Thr Cys Asn Asn Pro Ser Val
1505                1510                1515                1520
 Gln His Gly Gly Arg Pro Cys Glu Gly Asn Ala Val Glu Ile Ile Met
                1525                1530                1535    
 Cys Asn Ile Arg Pro Cys Pro Val His Gly Ala Trp Ser Ala Trp Gln
            1540                1545                1550        
 Pro Trp Gly Thr Cys Ser Glu Ser Cys Gly Lys Gly Thr Gln Thr Arg
        1555                1560                1565            
 Ala Arg Leu Cys Asn Asn Pro Pro Pro Ala Phe Gly Gly Ser Tyr Cys
    1570                1575                1580                
 Asp Gly Ala Glu Thr Gln Met Gln Val Cys Asn Glu Arg Asn Cys Pro
1585                1590                1595                1600
 Val His Gly Lys Trp Ala Thr Trp Ala Ser Trp Ser Ala Cys Ser Val
                1605                1610                1615    
 Ser Cys Gly Gly Gly Ala Arg Gln Arg Thr Arg Gly Cys Ser Asp Pro
            1620                1625                1630        
 Val Pro Gln Tyr Gly Gly Arg Lys Cys Glu Gly Ser Asp Val Gln Ser
        1635                1640                1645            
 Asp Phe Cys Asn Ser Asp Pro Cys Pro Thr His Gly Asn Trp Ser Pro
    1650                1655                1660                
 Trp Ser Gly Trp Gly Thr Cys Ser Arg Thr Cys Asn Gly Gly Gln Met
1665                1670                1675                1680
 Arg Arg Tyr Arg Thr Cys Asp Asn Pro Pro Pro Ser Asn Gly Gly Arg
                1685                1690                1695    
 Ala Cys Gly Gly Pro Asp Ser Gln Ile Gln Arg Cys Asn Thr Asp Met
            1700                1705                1710        
 Cys Pro Val Asp Gly Ser Trp Gly Ser Trp His Ser Trp Ser Gln Cys
        1715                1720                1725            
 Ser Ala Ser Cys Gly Gly Gly Glu Lys Thr Arg Lys Arg Leu Cys Asp
    1730                1735                1740                
 His Pro Val Pro Val Lys Gly Gly Arg Pro Cys Pro Gly Asp Thr Thr
1745                1750                1755                1760
 Gln Val Thr Arg Cys Asn Val Gln Ala Cys Pro Gly Gly Pro Gln Arg
                1765                1770                1775    
 Ala Arg Gly Ser Val Ile Gly Asn Ile Asn Asp Val Glu Phe Gly Ile
            1780                1785                1790        
 Ala Phe Leu Asn Ala Thr Ile Thr Asp Ser Pro Asn Ser Asp Thr Arg
        1795                1800                1805            
 Ile Ile Arg Ala Lys Ile Thr Asn Val Pro Arg Ser Leu Gly Ser Ala
    1810                1815                1820                
 Met Arg Lys Ile Val Ser Ile Leu Asn Pro Ile Tyr Trp Thr Thr Ala
1825                1830                1835                1840
 Lys Glu Ile Gly Glu Ala Val Asn Gly Phe Thr Leu Thr Asn Ala Val
                1845                1850                1855    
 Phe Lys Arg Glu Thr Gln Val Glu Phe Ala Thr Gly Glu Ile Leu Gln
            1860                1865                1870        
 Met Ser His Ile Ala Arg Gly Leu Asp Ser Asp Gly Ser Leu Leu Leu
        1875                1880                1885            
 Asp Ile Val Val Ser Gly Tyr Val Leu Gln Leu Gln Ser Pro Ala Glu
    1890                1895                1900                
 Val Thr Val Lys Asp Tyr Thr Glu Asp Tyr Ile Gln Thr Gly Pro Gly
1905                1910                1915                1920
 Gln Leu Tyr Ala Tyr Ser Thr Arg Leu Phe Thr Ile Asp Gly Ile Ser
                1925                1930                1935    
 Ile Pro Tyr Thr Trp Asn His Thr Val Phe Tyr Asp Gln Ala Gln Gly
            1940                1945                1950        
 Arg Met Pro Phe Leu Val Glu Thr Leu His Ala Ser Ser Val Glu Ser
        1955                1960                1965            
 Asp Tyr Asn Gln Ile Glu Glu Thr Leu Gly Phe Lys Ile His Ala Ser
    1970                1975                1980                
 Ile Ser Lys Gly Asp Arg Ser Asn Gln Cys Pro Ser Gly Phe Thr Leu
1985                1990                1995                2000
 Asp Ser Val Gly Pro Phe Cys Ala Asp Glu Asp Glu Cys Ala Ala Gly
                2005                2010                2015    
 Asn Pro Cys Ser His Ser Cys His Asn Ala Met Gly Thr Tyr Tyr Cys
            2020                2025                2030        
 Ser Cys Pro Lys Gly Leu Thr Ile Ala Ala Asp Gly Arg Thr Cys Gln
        2035                2040                2045            
 Asp Ile Asp Glu Cys Ala Leu Gly Arg His Thr Cys His Ala Gly Gln
    2050                2055                2060                
 Asp Cys Asp Asn Thr Ile Gly Ser Tyr Arg Cys Val Val Arg Cys Gly
2065                2070                2075                2080
 Ser Gly Phe Arg Arg Thr Ser Asp Gly Leu Ser Cys Gln Asp Ile Asn
                2085                2090                2095    
 Glu Cys Gln Glu Ser Ser Pro Cys His Gln Arg Cys Phe Asn Ala Ile
            2100                2105                2110        
 Gly Ser Phe His Cys Gly Cys Glu Pro Gly Tyr Gln Leu Lys Gly Arg
        2115                2120                2125            
 Lys Cys Met Asp Val Asn Glu Cys Arg Gln Asn Val Cys Arg Pro Asp
    2130                2135                2140                
 Gln His Cys Lys Asn Thr Arg Gly Gly Tyr Lys Cys Ile Asp Leu Cys
2145                2150                2155                2160
 Pro Asn Gly Met Thr Lys Ala Glu Asn Gly Thr Cys Ile Asp Ile Asp
                2165                2170                2175    
 Glu Cys Lys Asp Gly Thr His Gln Cys Arg Tyr Asn Gln Ile Cys Glu
            2180                2185                2190        
 Asn Thr Arg Gly Ser Tyr Arg Cys Val Cys Pro Arg Gly Tyr Arg Ser
        2195                2200                2205            
 Gln Gly Val Gly Arg Pro Cys Met Asp Ile Asn Glu Cys Glu Gln Val
    2210                2215                2220                
 Pro Lys Pro Cys Ala His Gln Cys Ser Asn Thr Pro Gly Ser Phe Lys
2225                2230                2235                2240
 Cys Ile Cys Pro Pro Gly Gln His Leu Leu Gly Asp Gly Lys Ser Cys
                2245                2250                2255    
 Ala Gly Leu Glu Arg Leu Pro Asn Tyr Gly Thr Gln Tyr Ser Ser Tyr
            2260                2265                2270        
 Asn Leu Ala Arg Phe Ser Pro Val Arg Asn Asn Tyr Gln Pro Gln Gln
        2275                2280                2285            
 His Tyr Arg Gln Tyr Ser His Leu Tyr Ser Ser Tyr Ser Glu Tyr Arg
    2290                2295                2300                
 Asn Ser Arg Thr Ser Leu Ser Arg Thr Arg Arg Thr Ile Arg Lys Thr
2305                2310                2315                2320
 Cys Pro Glu Gly Ser Glu Ala Ser His Asp Thr Cys Val Asp Ile Asp
                2325                2330                2335    
 Glu Cys Glu Asn Thr Asp Ala Cys Gln His Glu Cys Lys Asn Thr Phe
            2340                2345                2350        
 Gly Ser Tyr Gln Cys Ile Cys Pro Pro Gly Tyr Gln Leu Thr His Asn
        2355                2360                2365            
 Gly Lys Thr Cys Gln Asp Ile Asp Glu Cys Leu Glu Gln Asn Val His
    2370                2375                2380                
 Cys Gly Pro Asn Arg Met Cys Phe Asn Met Arg Gly Ser Tyr Gln Cys
2385                2390                2395                2400
 Ile Asp Thr Pro Cys Pro Pro Asn Tyr Gln Arg Asp Pro Val Ser Gly
                2405                2410                2415    
 Phe Cys Leu Lys Asn Cys Pro Pro Asn Asp Leu Glu Cys Ala Leu Ser
            2420                2425                2430        
 Pro Tyr Ala Leu Glu Tyr Lys Leu Val Ser Leu Pro Phe Gly Ile Ala
        2435                2440                2445            
 Thr Asn Gln Asp Leu Ile Arg Leu Val Ala Tyr Thr Gln Asp Gly Val
    2450                2455                2460                
 Met His Pro Arg Thr Thr Phe Leu Met Val Asp Glu Glu Gln Thr Val
2465                2470                2475                2480
 Pro Phe Ala Leu Arg Asp Glu Asn Leu Lys Gly Val Val Tyr Thr Thr
                2485                2490                2495    
 Arg Pro Leu Arg Glu Ala Glu Thr Tyr Arg Met Arg Val Arg Ala Ser
            2500                2505                2510        
 Ser Tyr Ser Ala Asn Gly Thr Ile Glu Tyr Gln Thr Thr Phe Ile Val
        2515                2520                2525            
 Tyr Ile Ala Val Ser Ala Tyr Pro Tyr
    2530                2535        



      <210> 721
      <211> 747
      <212> PRT
      <213> Homo sapiens


      <400> 721
 Met Glu Val Lys Arg Leu Lys Val Thr Glu Leu Arg Ser Glu Leu Gln
   1               5                  10                  15    
 Arg Arg Gly Leu Asp Ser Arg Gly Leu Lys Val Asp Leu Ala Gln Arg
              20                  25                  30        
 Leu Gln Glu Ala Leu Asp Ala Glu Met Leu Glu Asp Glu Ala Gly Gly
          35                  40                  45            
 Gly Gly Ala Gly Pro Gly Gly Ala Cys Lys Ala Glu Pro Arg Pro Val
      50                  55                  60                
 Ala Ala Ser Gly Gly Gly Pro Gly Gly Asp Glu Glu Glu Asp Glu Glu
  65                  70                  75                  80
 Glu Glu Glu Glu Asp Glu Glu Ala Leu Leu Glu Asp Glu Asp Glu Glu
                  85                  90                  95    
 Pro Pro Pro Ala Gln Ala Leu Gly Gln Ala Ala Gln Pro Pro Pro Glu
             100                 105                 110        
 Pro Pro Glu Ala Ala Ala Met Glu Ala Ala Ala Glu Pro Asp Ala Ser
         115                 120                 125            
 Glu Lys Pro Ala Glu Ala Thr Ala Gly Ser Gly Gly Val Asn Gly Gly
     130                 135                 140                
 Glu Glu Gln Gly Leu Gly Lys Arg Glu Glu Asp Glu Pro Glu Glu Arg
 145                 150                 155                 160
 Ser Gly Asp Glu Thr Pro Gly Ser Glu Val Pro Gly Asp Lys Ala Ala
                 165                 170                 175    
 Glu Glu Gln Gly Asp Asp Gln Asp Ser Glu Lys Ser Lys Pro Ala Gly
             180                 185                 190        
 Ser Asp Gly Glu Arg Arg Gly Val Lys Arg Gln Arg Asp Glu Lys Asp
         195                 200                 205            
 Glu His Gly Arg Ala Tyr Tyr Glu Phe Arg Glu Glu Ala Tyr His Ser
     210                 215                 220                
 Arg Ser Lys Ser Pro Leu Pro Pro Glu Glu Glu Ala Lys Asp Glu Glu
 225                 230                 235                 240
 Glu Asp Gln Thr Leu Val Asn Leu Asp Thr Tyr Thr Ser Asp Leu His
                 245                 250                 255    
 Phe Gln Val Ser Lys Asp Arg Tyr Gly Gly Gln Pro Leu Phe Ser Glu
             260                 265                 270        
 Lys Phe Pro Thr Leu Trp Ser Gly Ala Arg Ser Thr Tyr Gly Val Thr
         275                 280                 285            
 Lys Gly Lys Val Cys Phe Glu Ala Lys Val Thr Gln Asn Leu Pro Met
     290                 295                 300                
 Lys Glu Gly Cys Thr Glu Val Ser Leu Leu Arg Val Gly Trp Ser Val
 305                 310                 315                 320
 Asp Phe Ser Arg Pro Gln Leu Gly Glu Asp Glu Phe Ser Tyr Gly Phe
                 325                 330                 335    
 Asp Gly Arg Gly Leu Lys Ala Glu Asn Gly Gln Phe Glu Glu Phe Gly
             340                 345                 350        
 Gln Thr Phe Gly Glu Asn Asp Val Ile Gly Cys Phe Ala Asn Phe Glu
         355                 360                 365            
 Thr Glu Glu Val Glu Leu Ser Phe Ser Lys Asn Gly Glu Asp Leu Gly
     370                 375                 380                
 Val Ala Phe Trp Ile Ser Lys Asp Ser Leu Ala Asp Arg Ala Leu Leu
 385                 390                 395                 400
 Pro His Val Leu Cys Lys Asn Cys Val Val Glu Leu Asn Phe Gly Gln
                 405                 410                 415    
 Lys Glu Glu Pro Phe Phe Pro Pro Pro Glu Glu Phe Val Phe Ile His
             420                 425                 430        
 Ala Val Pro Val Glu Glu Arg Val Arg Thr Ala Val Pro Pro Lys Thr
         435                 440                 445            
 Ile Glu Glu Cys Glu Val Ile Leu Met Val Gly Leu Pro Gly Ser Gly
     450                 455                 460                
 Lys Thr Gln Trp Ala Leu Lys Tyr Ala Lys Glu Asn Pro Glu Lys Arg
 465                 470                 475                 480
 Tyr Asn Val Leu Gly Ala Glu Thr Val Leu Asn Gln Met Arg Met Lys
                 485                 490                 495    
 Gly Leu Glu Glu Pro Glu Met Asp Pro Lys Ser Arg Asp Leu Leu Val
             500                 505                 510        
 Gln Gln Ala Ser Gln Cys Leu Ser Lys Leu Val Gln Ile Ala Ser Arg
         515                 520                 525            
 Thr Lys Arg Asn Phe Ile Leu Asp Gln Cys Asn Val Tyr Asn Ser Gly
     530                 535                 540                
 Gln Arg Arg Lys Leu Leu Leu Phe Lys Thr Phe Ser Arg Lys Val Val
 545                 550                 555                 560
 Val Val Val Pro Asn Glu Glu Asp Trp Lys Lys Arg Leu Glu Leu Arg
                 565                 570                 575    
 Lys Glu Val Glu Gly Asp Asp Val Pro Glu Ser Ile Met Leu Glu Met
             580                 585                 590        
 Lys Ala Asn Phe Ser Leu Pro Glu Lys Cys Asp Tyr Met Asp Glu Val
         595                 600                 605            
 Thr Tyr Gly Glu Leu Glu Lys Glu Glu Ala Gln Pro Ile Val Thr Lys
     610                 615                 620                
 Tyr Lys Glu Glu Ala Arg Lys Leu Leu Pro Pro Ser Glu Lys Arg Thr
 625                 630                 635                 640
 Asn Arg Arg Asn Asn Arg Asn Lys Arg Asn Arg Gln Asn Arg Ser Arg
                 645                 650                 655    
 Gly Gln Gly Tyr Val Gly Gly Gln Arg Arg Gly Tyr Asp Asn Arg Ala
             660                 665                 670        
 Tyr Gly Gln Gln Tyr Trp Gly Gln Pro Gly Asn Arg Gly Gly Tyr Arg
         675                 680                 685            
 Asn Phe Tyr Asp Arg Tyr Arg Gly Asp Tyr Asp Arg Phe Tyr Gly Arg
     690                 695                 700                
 Asp Tyr Glu Tyr Asn Arg Tyr Arg Asp Tyr Tyr Arg Gln Tyr Asn Arg
 705                 710                 715                 720
 Asp Trp Gln Ser Tyr Tyr Tyr His His Pro Gln Asp Arg Asp Arg Tyr
                 725                 730                 735    
 Tyr Arg Asn Tyr Tyr Gly Tyr Gln Gly Tyr Arg
             740                 745        



      <210> 722
      <211> 1633
      <212> PRT
      <213> Homo sapiens


      <400> 722
 Met Val Lys Lys Glu Ile Ser Val Arg Gln Gln Ile Gln Ala Leu Leu
   1               5                  10                  15    
 Tyr Lys Asn Phe Leu Lys Lys Trp Arg Ile Lys Arg Glu Val Leu Glu
              20                  25                  30        
 Glu Trp Thr Ile Thr Leu Phe Leu Gly Leu Tyr Leu Cys Ile Phe Ser
          35                  40                  45            
 Glu His Phe Arg Ala Thr Arg Phe Pro Glu Gln Pro Pro Lys Val Leu
      50                  55                  60                
 Gly Ser Val Asp Gln Phe Asn Asp Ser Gly Leu Val Val Ala Tyr Thr
  65                  70                  75                  80
 Pro Val Ser Asn Ile Thr Gln Arg Ile Met Asn Lys Met Ala Leu Ala
                  85                  90                  95    
 Ser Phe Tyr Met Val Gly Arg Thr Val Ile Gly Thr Pro Asp Glu Glu
             100                 105                 110        
 Thr Met Asp Ile Glu Leu Pro Lys Lys Tyr His Glu Met Val Gly Val
         115                 120                 125            
 Ile Phe Ser Asp Thr Phe Ser Tyr Arg Leu Lys Phe Asn Trp Gly Tyr
     130                 135                 140                
 Arg Ile Pro Val Ile Lys Glu His Ser Glu Tyr Thr Ala His Cys Trp
 145                 150                 155                 160
 Ala Met His Gly Glu Ile Phe Cys Tyr Leu Ala Lys Tyr Trp Leu Lys
                 165                 170                 175    
 Gly Phe Val Ala Phe Gln Ala Ala Ile Asn Ala Ala Ile Ile Glu Val
             180                 185                 190        
 Thr Thr Asn His Ser Val Met Glu Glu Leu Thr Ser Val Ile Gly Ile
         195                 200                 205            
 Asn Met Lys Ile Pro Pro Phe Ile Ser Lys Gly Glu Ile Met Asn Glu
     210                 215                 220                
 Trp Phe His Phe Thr Cys Leu Val Ser Phe Ser Ser Phe Ile Tyr Phe
 225                 230                 235                 240
 Ala Ser Leu Asn Val Ala Arg Glu Arg Gly Lys Phe Lys Lys Leu Met
                 245                 250                 255    
 Thr Val Met Gly Leu Arg Glu Ser Ala Phe Trp Leu Ser Trp Arg Leu
             260                 265                 270        
 Thr Tyr Ile Cys Phe Ile Phe Ile Met Ser Ile Phe Met Ala Leu Val
         275                 280                 285            
 Ile Thr Ser Ile Ser Ile Val Phe His Thr Gly Phe Met Val Ile Phe
     290                 295                 300                
 Thr Leu Tyr Ser Leu Tyr Gly Leu Ser Leu Ile Ala Leu Ala Phe Leu
 305                 310                 315                 320
 Met Ser Val Leu Ile Arg Lys Pro Met Leu Ala Gly Leu Ala Gly Phe
                 325                 330                 335    
 Leu Phe Thr Val Phe Trp Gly Cys Leu Gly Phe Thr Val Leu Tyr Arg
             340                 345                 350        
 Gln Leu Pro Leu Ser Leu Gly Trp Val Leu Ser Leu Leu Ser Pro Phe
         355                 360                 365            
 Ala Phe Thr Ala Gly Met Ala Gln Val Thr His Leu Asp Asn Tyr Leu
     370                 375                 380                
 Ser Gly Val Ile Phe Pro Asp Pro Ser Gly Asp Ser Tyr Lys Met Ile
 385                 390                 395                 400
 Ala Thr Phe Phe Ile Leu Ala Phe Asp Thr Leu Phe Tyr Leu Ile Phe
                 405                 410                 415    
 Thr Leu Tyr Phe Glu Arg Val Leu Pro Asp Lys Asp Gly His Gly Asp
             420                 425                 430        
 Ser Pro Leu Phe Phe Leu Lys Ser Ser Phe Trp Ser Lys His Gln Asn
         435                 440                 445            
 Thr His His Glu Ile Phe Glu Asn Glu Ile Asn Pro Glu His Ser Ser
     450                 455                 460                
 Asp Asp Ser Phe Glu Pro Val Ser Pro Glu Phe His Gly Lys Glu Ala
 465                 470                 475                 480
 Ile Arg Ile Arg Asn Val Ile Lys Glu Tyr Asn Gly Lys Thr Gly Lys
                 485                 490                 495    
 Val Glu Ala Leu Gln Gly Ile Phe Phe Asp Ile Tyr Glu Gly Gln Ile
             500                 505                 510        
 Thr Ala Ile Leu Gly His Asn Gly Ala Gly Lys Ser Thr Leu Leu Asn
         515                 520                 525            
 Ile Leu Ser Gly Leu Ser Val Ser Thr Glu Gly Ser Ala Thr Ile Tyr
     530                 535                 540                
 Asn Thr Gln Leu Ser Glu Ile Thr Asp Met Glu Glu Ile Arg Lys Asn
 545                 550                 555                 560
 Ile Gly Phe Cys Pro Gln Phe Asn Phe Gln Phe Asp Phe Leu Thr Val
                 565                 570                 575    
 Arg Glu Asn Leu Arg Val Phe Ala Lys Ile Lys Gly Ile Gln Pro Lys
             580                 585                 590        
 Glu Val Glu Gln Glu Val Lys Arg Ile Ile Met Glu Leu Asp Met Gln
         595                 600                 605            
 Ser Ile Gln Asp Ile Ile Ala Lys Lys Leu Ser Gly Gly Gln Lys Arg
     610                 615                 620                
 Lys Leu Thr Leu Gly Ile Ala Ile Leu Gly Asp Pro Gln Val Leu Leu
 625                 630                 635                 640
 Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Phe Ser Arg His Arg Val
                 645                 650                 655    
 Trp Ser Leu Leu Lys Glu His Lys Val Asp Arg Leu Ile Leu Phe Ser
             660                 665                 670        
 Thr Gln Phe Met Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Val Phe
         675                 680                 685            
 Leu Ser Asn Gly Lys Leu Lys Cys Ala Gly Ser Ser Leu Phe Leu Lys
     690                 695                 700                
 Arg Lys Trp Gly Ile Gly Tyr His Leu Ser Leu His Arg Asn Glu Met
 705                 710                 715                 720
 Cys Asp Thr Glu Lys Ile Thr Ser Leu Ile Lys Gln His Ile Pro Asp
                 725                 730                 735    
 Ala Lys Leu Thr Thr Glu Ser Glu Glu Lys Leu Val Tyr Ser Leu Pro
             740                 745                 750        
 Leu Glu Lys Thr Asn Lys Phe Pro Asp Leu Tyr Ser Asp Leu Asp Lys
         755                 760                 765            
 Cys Ser Asp Gln Gly Ile Arg Asn Tyr Ala Val Ser Val Thr Ser Leu
     770                 775                 780                
 Asn Glu Val Phe Leu Asn Leu Glu Gly Lys Ser Ala Ile Asp Glu Pro
 785                 790                 795                 800
 Asp Phe Asp Ile Gly Lys Gln Glu Lys Ile His Val Thr Arg Asn Thr
                 805                 810                 815    
 Gly Asp Glu Ser Glu Met Glu Gln Val Leu Cys Ser Leu Pro Glu Thr
             820                 825                 830        
 Arg Lys Ala Val Ser Ser Ala Ala Leu Trp Arg Arg Gln Ile Tyr Ala
         835                 840                 845            
 Val Ala Thr Leu Arg Phe Leu Lys Leu Arg Arg Glu Arg Arg Ala Leu
     850                 855                 860                
 Leu Cys Leu Leu Leu Val Leu Gly Ile Ala Phe Ile Pro Ile Ile Leu
 865                 870                 875                 880
 Glu Lys Ile Met Tyr Lys Val Thr Arg Glu Thr His Cys Trp Glu Phe
                 885                 890                 895    
 Ser Pro Ser Met Tyr Phe Leu Ser Leu Glu Gln Ile Pro Lys Thr Pro
             900                 905                 910        
 Leu Thr Ser Leu Leu Ile Val Asn Asn Thr Gly Ser Asn Ile Glu Asp
         915                 920                 925            
 Leu Val His Ser Leu Lys Cys Gln Asp Ile Val Leu Glu Ile Asp Asp
     930                 935                 940                
 Phe Arg Asn Arg Asn Gly Ser Asp Asp Pro Ser Tyr Asn Gly Ala Ile
 945                 950                 955                 960
 Ile Val Ser Gly Asp Gln Lys Asp Tyr Arg Phe Ser Val Ala Cys Asn
                 965                 970                 975    
 Thr Lys Lys Leu Asn Cys Phe Pro Val Leu Met Gly Ile Val Ser Asn
             980                 985                 990        
 Ala Leu Met Gly Ile Phe Asn Phe Thr Glu Leu Ile Gln Thr Glu Ser
         995                1000                1005            
 Thr Ser Phe Ser Arg Asp Asp Ile Val Leu Asp Leu Gly Phe Ile Asp
    1010                1015                1020                
 Gly Ser Ile Phe Leu Leu Leu Ile Thr Asn Cys Val Ser Pro Phe Ile
1025                1030                1035                1040
 Gly Met Ser Ser Ile Ser Asp Tyr Lys Lys Asn Val Gln Ser Gln Leu
                1045                1050                1055    
 Trp Ile Ser Gly Leu Trp Pro Ser Ala Tyr Trp Cys Gly Gln Ala Leu
            1060                1065                1070        
 Val Asp Ile Pro Leu Tyr Phe Leu Ile Leu Phe Ser Ile His Leu Ile
        1075                1080                1085            
 Tyr Tyr Phe Ile Phe Leu Gly Phe Gln Leu Ser Trp Glu Leu Met Phe
    1090                1095                1100                
 Val Leu Val Val Cys Ile Ile Gly Cys Ala Val Ser Leu Ile Phe Leu
1105                1110                1115                1120
 Thr Tyr Val Leu Ser Phe Ile Phe Arg Lys Trp Arg Lys Asn Asn Gly
                1125                1130                1135    
 Phe Trp Ser Phe Gly Phe Phe Ile Ile Leu Ile Cys Val Ser Thr Ile
            1140                1145                1150        
 Met Val Ser Thr Gln Tyr Glu Lys Leu Asn Leu Ile Leu Cys Met Ile
        1155                1160                1165            
 Phe Ile Pro Ser Phe Thr Leu Leu Gly Tyr Val Met Leu Leu Ile Gln
    1170                1175                1180                
 Leu Asp Phe Met Arg Asn Leu Asp Ser Leu Asp Asn Arg Ile Asn Glu
1185                1190                1195                1200
 Val Asn Lys Thr Ile Leu Leu Thr Thr Leu Ile Pro Tyr Leu Gln Ser
                1205                1210                1215    
 Val Ile Phe Leu Phe Val Ile Arg Cys Leu Glu Met Lys Tyr Gly Asn
            1220                1225                1230        
 Glu Ile Met Asn Lys Asp Pro Val Phe Arg Ile Ser Pro Arg Ser Arg
        1235                1240                1245            
 Glu Thr His Pro Asn Pro Glu Glu Pro Glu Glu Glu Asp Glu Asp Val
    1250                1255                1260                
 Gln Ala Glu Arg Val Gln Ala Ala Asn Ala Leu Thr Ala Pro Asn Leu
1265                1270                1275                1280
 Glu Glu Glu Pro Val Ile Thr Ala Ser Cys Leu His Lys Glu Tyr Tyr
                1285                1290                1295    
 Glu Thr Lys Lys Ser Cys Phe Ser Thr Arg Lys Lys Lys Ile Ala Ile
            1300                1305                1310        
 Arg Asn Val Ser Phe Cys Val Lys Lys Gly Glu Val Leu Gly Leu Leu
        1315                1320                1325            
 Gly His Asn Gly Ala Gly Lys Ser Thr Ser Ile Lys Met Ile Thr Gly
    1330                1335                1340                
 Cys Thr Lys Pro Thr Ala Gly Val Val Val Leu Gln Gly Ser Arg Ala
1345                1350                1355                1360
 Ser Val Arg Gln Gln His Asp Asn Ser Leu Lys Phe Leu Gly Tyr Cys
                1365                1370                1375    
 Pro Gln Glu Asn Ser Leu Trp Pro Lys Leu Thr Met Lys Glu His Leu
            1380                1385                1390        
 Glu Leu Tyr Ala Ala Val Lys Gly Leu Gly Lys Glu Asp Ala Ala Leu
        1395                1400                1405            
 Ser Ile Ser Arg Leu Val Glu Ala Leu Lys Leu Gln Glu Gln Leu Lys
    1410                1415                1420                
 Ala Pro Val Lys Thr Leu Ser Glu Gly Ile Lys Arg Lys Leu Cys Phe
1425                1430                1435                1440
 Val Leu Ser Ile Leu Gly Asn Pro Ser Val Val Leu Leu Asp Glu Pro
                1445                1450                1455    
 Phe Thr Gly Met Asp Pro Glu Gly Gln Gln Gln Met Trp Gln Ile Leu
            1460                1465                1470        
 Gln Ala Thr Val Lys Asn Lys Glu Arg Gly Thr Leu Leu Thr Thr His
        1475                1480                1485            
 Tyr Met Ser Glu Ala Glu Ala Val Cys Asp Arg Met Ala Met Met Val
    1490                1495                1500                
 Ser Gly Thr Leu Arg Cys Ile Gly Ser Ile Gln His Leu Lys Asn Lys
1505                1510                1515                1520
 Phe Gly Arg Asp Tyr Leu Leu Glu Ile Lys Met Lys Glu Pro Thr Gln
                1525                1530                1535    
 Val Glu Ala Leu His Thr Glu Ile Leu Lys Leu Phe Pro Gln Ala Ala
            1540                1545                1550        
 Trp Gln Glu Arg Tyr Ser Ser Leu Met Ala Tyr Lys Leu Pro Val Glu
        1555                1560                1565            
 Asp Val His Pro Leu Ser Arg Ala Phe Phe Lys Leu Glu Ala Met Lys
    1570                1575                1580                
 Gln Thr Phe Asn Leu Glu Glu Tyr Ser Leu Ser Gln Ala Thr Leu Glu
1585                1590                1595                1600
 Gln Val Phe Leu Glu Leu Cys Lys Glu Gln Glu Leu Gly Asn Val Asp
                1605                1610                1615    
 Asp Lys Ile Asp Thr Thr Val Glu Trp Lys Leu Leu Pro Gln Glu Asp
            1620                1625                1630        
 Pro
    



      <210> 723
      <211> 716
      <212> PRT
      <213> Homo sapiens


      <400> 723
 Met Cys Glu Ser Tyr Ser Arg Ser Leu Leu Arg Val Ser Val Ala Gln
   1               5                  10                  15    
 Ile Cys Gln Ala Leu Gly Trp Asp Ser Val Gln Leu Ser Ala Cys His
              20                  25                  30        
 Leu Leu Thr Asp Val Leu Gln Arg Tyr Leu Gln Gln Leu Gly Arg Gly
          35                  40                  45            
 Cys His Arg Tyr Ser Glu Leu Tyr Gly Arg Thr Asp Pro Ile Leu Asp
      50                  55                  60                
 Asp Val Gly Glu Ala Phe Gln Leu Met Gly Val Ser Leu His Glu Leu
  65                  70                  75                  80
 Glu Asp Tyr Ile His Asn Ile Glu Pro Val Thr Phe Pro His Gln Ile
                  85                  90                  95    
 Pro Ser Phe Pro Val Ser Lys Asn Asn Val Leu Gln Phe Pro Gln Pro
             100                 105                 110        
 Gly Ser Lys Asp Ala Glu Glu Arg Lys Glu Tyr Ile Pro Asp Tyr Leu
         115                 120                 125            
 Pro Pro Ile Val Ser Ser Gln Glu Glu Glu Glu Glu Glu Gln Val Pro
     130                 135                 140                
 Thr Asp Gly Gly Thr Ser Ala Glu Ala Met Gln Val Pro Leu Glu Glu
 145                 150                 155                 160
 Asp Asp Glu Leu Glu Glu Glu Glu Ile Ile Asn Asp Glu Asn Phe Leu
                 165                 170                 175    
 Gly Lys Arg Pro Leu Asp Ser Pro Glu Ala Glu Glu Leu Pro Ala Met
             180                 185                 190        
 Lys Arg Pro Arg Leu Leu Ser Thr Lys Gly Asp Thr Leu Asp Val Val
         195                 200                 205            
 Leu Leu Glu Ala Arg Glu Pro Leu Ser Ser Ile Asn Thr Gln Lys Ile
     210                 215                 220                
 Pro Pro Met Leu Ser Pro Val His Val Gln Asp Ser Thr Asp Leu Ala
 225                 230                 235                 240
 Pro Pro Ser Pro Glu Pro Pro Met Leu Ala Pro Val Ala Lys Ser Gln
                 245                 250                 255    
 Met Pro Thr Ala Lys Pro Leu Glu Thr Lys Ser Phe Thr Pro Lys Thr
             260                 265                 270        
 Lys Thr Lys Thr Ser Ser Pro Gly Gln Lys Thr Lys Ser Pro Lys Thr
         275                 280                 285            
 Ala Gln Ser Pro Ala Met Val Gly Ser Pro Ile Arg Ser Pro Lys Thr
     290                 295                 300                
 Val Ser Lys Glu Lys Lys Ser Pro Gly Arg Ser Lys Ser Pro Lys Ser
 305                 310                 315                 320
 Pro Lys Ser Pro Lys Val Thr Thr His Ile Pro Gln Thr Pro Val Arg
                 325                 330                 335    
 Pro Glu Thr Pro Asn Arg Thr Pro Ser Ala Thr Leu Ser Glu Lys Ile
             340                 345                 350        
 Ser Lys Glu Thr Ile Gln Val Lys Gln Ile Gln Thr Pro Pro Asp Ala
         355                 360                 365            
 Gly Lys Leu Asn Ser Glu Asn Gln Pro Lys Lys Ala Val Val Ala Asp
     370                 375                 380                
 Lys Thr Ile Glu Ala Ser Ile Asp Ala Val Ile Ala Arg Ala Cys Ala
 385                 390                 395                 400
 Glu Arg Glu Pro Asp Pro Phe Glu Phe Ser Ser Gly Ser Glu Ser Glu
                 405                 410                 415    
 Gly Asp Ile Phe Thr Ser Pro Lys Arg Ile Ser Gly Pro Glu Cys Thr
             420                 425                 430        
 Thr Pro Lys Ala Ser Thr Ser Ala Asn Asn Phe Thr Lys Ser Gly Ser
         435                 440                 445            
 Thr Pro Leu Pro Leu Ser Gly Gly Thr Ser Ser Ser Asp Asn Ser Trp
     450                 455                 460                
 Thr Met Asp Ala Ser Ile Asp Glu Val Val Arg Lys Ala Lys Leu Gly
 465                 470                 475                 480
 Thr Pro Ser Asn Met Pro Pro Asn Phe Pro Tyr Ile Ser Ser Pro Ser
                 485                 490                 495    
 Val Ser Pro Pro Thr Pro Glu Pro Leu His Lys Val Tyr Glu Glu Lys
             500                 505                 510        
 Thr Lys Leu Pro Ser Ser Val Glu Val Lys Lys Lys Leu Lys Lys Glu
         515                 520                 525            
 Leu Lys Thr Lys Met Lys Lys Lys Glu Lys Gln Arg Asp Arg Glu Arg
     530                 535                 540                
 Glu Lys Asp Lys Asn Lys Asp Lys Ser Lys Glu Lys Asp Lys Val Lys
 545                 550                 555                 560
 Glu Lys Glu Lys Asp Lys Glu Thr Gly Arg Glu Thr Lys Tyr Pro Trp
                 565                 570                 575    
 Lys Glu Phe Leu Lys Glu Glu Glu Ala Asp Pro Tyr Lys Phe Lys Ile
             580                 585                 590        
 Lys Glu Phe Glu Asp Val Asp Pro Lys Val Lys Leu Lys Asp Gly Leu
         595                 600                 605            
 Val Arg Lys Glu Lys Glu Lys His Lys Asp Lys Lys Lys Asp Arg Glu
     610                 615                 620                
 Lys Gly Lys Lys Asp Lys Asp Lys Arg Glu Lys Glu Lys Val Lys Asp
 625                 630                 635                 640
 Lys Gly Arg Glu Asp Lys Met Lys Ala Pro Ala Pro Pro Leu Val Leu
                 645                 650                 655    
 Pro Pro Lys Glu Leu Ala Leu Pro Leu Phe Ser Pro Ala Thr Ala Ser
             660                 665                 670        
 Arg Val Pro Ala Met Leu Pro Ser Leu Leu Pro Val Leu Pro Glu Lys
         675                 680                 685            
 Leu Phe Glu Glu Lys Glu Lys Pro Lys Glu Lys Glu Lys Lys Lys Asp
     690                 695                 700                
 Lys Lys Glu Lys Lys Lys Lys Lys Gly Arg Pro Leu
 705                 710                 715    



      <210> 724
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 724
 Met Ile Leu Val Pro Met Asn Thr Pro Gly Val Lys Ile Ile Arg Pro
   1               5                  10                  15    
 Leu Ser Val Phe Gly Tyr Thr Asp Asn Phe His Gly Gly His Phe Glu
              20                  25                  30        
 Ile His Phe Asn Gln Val Arg Val Pro Ala Thr Asn Leu Ile Leu Gly
          35                  40                  45            
 Glu Gly Arg Gly Phe Glu Ile Ser Gln Gly Arg Leu Gly Pro Gly Arg
      50                  55                  60                
 Ile His His Cys Met Arg Thr Val Gly Leu Ala Glu Arg Ala Leu Gln
  65                  70                  75                  80
 Ile Met Cys Glu Arg Ala Thr Gln Arg Ile Ala Phe Lys Lys Lys Leu
                  85                  90                  95    
 Tyr Ala His Glu Val Val Ala His Trp Ile Ala Glu Ser Arg Ile Ala
             100                 105                 110        
 Ile Glu Lys Ile Arg Leu Leu Thr Leu Lys Ala Ala His Ser Met Asp
         115                 120                 125            
 Thr Leu Gly Ser Ala Gly Ala Lys Lys Glu Ile Ala Met Ile Lys Val
     130                 135                 140                
 Ala Ala Pro Arg Ala Val Ser Lys Ile Val Asp Trp Ala Ile Gln Val
 145                 150                 155                 160
 Cys Gly Gly Ala Gly Val Ser Gln Asp Tyr Pro Leu Ala Asn Met Tyr
                 165                 170                 175    
 Ala Ile Thr Arg Val Leu Arg Leu Ala Asp Gly Pro Asp Glu Val His
             180                 185                 190        
 Leu Ser Ala Ile Ala Thr Met Glu Leu Arg Asp Gln Ala Lys Arg Leu
         195                 200                 205            
 Thr Ala Lys Ile
     210        



      <210> 725
      <211> 553
      <212> PRT
      <213> Homo sapiens


      <400> 725
 Met Pro Leu Pro Trp Ser Leu Ala Leu Pro Leu Leu Leu Ser Trp Val
   1               5                  10                  15    
 Ala Gly Gly Phe Gly Asn Ala Ala Ser Ala Arg His His Gly Leu Leu
              20                  25                  30        
 Ala Ser Ala Arg Gln Pro Gly Val Cys His Tyr Gly Thr Lys Leu Ala
          35                  40                  45            
 Cys Cys Tyr Gly Trp Arg Arg Asn Ser Lys Gly Val Cys Glu Ala Thr
      50                  55                  60                
 Cys Glu Pro Gly Cys Lys Phe Gly Glu Cys Val Gly Pro Asn Lys Cys
  65                  70                  75                  80
 Arg Cys Phe Pro Gly Tyr Thr Gly Lys Thr Cys Ser Gln Asp Val Asn
                  85                  90                  95    
 Glu Cys Gly Met Lys Pro Arg Pro Cys Gln His Arg Cys Val Asn Thr
             100                 105                 110        
 His Gly Ser Tyr Lys Cys Phe Cys Leu Ser Gly His Met Leu Met Pro
         115                 120                 125            
 Asp Ala Thr Cys Val Asn Ser Arg Thr Cys Ala Met Ile Asn Cys Gln
     130                 135                 140                
 Tyr Ser Cys Glu Asp Thr Glu Glu Gly Pro Gln Cys Leu Cys Pro Ser
 145                 150                 155                 160
 Ser Gly Leu Arg Leu Ala Pro Asn Gly Arg Asp Cys Leu Asp Ile Asp
                 165                 170                 175    
 Glu Cys Ala Ser Gly Lys Val Ile Cys Pro Tyr Asn Arg Arg Cys Val
             180                 185                 190        
 Asn Thr Phe Gly Ser Tyr Tyr Cys Lys Cys His Ile Gly Phe Glu Leu
         195                 200                 205            
 Gln Tyr Ile Ser Gly Arg Tyr Asp Cys Ile Asp Ile Asn Glu Cys Thr
     210                 215                 220                
 Met Asp Ser His Thr Cys Ser His His Ala Asn Cys Phe Asn Thr Gln
 225                 230                 235                 240
 Gly Ser Phe Lys Cys Lys Cys Lys Gln Gly Tyr Lys Gly Asn Gly Leu
                 245                 250                 255    
 Arg Cys Ser Ala Ile Pro Glu Asn Ser Val Lys Glu Val Leu Arg Ala
             260                 265                 270        
 Pro Gly Thr Ile Lys Asp Arg Ile Lys Lys Leu Leu Ala His Lys Asn
         275                 280                 285            
 Ser Met Lys Lys Lys Ala Lys Ile Lys Asn Val Thr Pro Glu Pro Thr
     290                 295                 300                
 Arg Thr Pro Thr Pro Lys Val Asn Leu Gln Pro Phe Asn Tyr Glu Glu
 305                 310                 315                 320
 Ile Val Ser Arg Gly Gly Asn Ser His Gly Gly Lys Lys Gly Asn Glu
                 325                 330                 335    
 Glu Lys Met Lys Glu Gly Leu Glu Asp Glu Lys Arg Glu Glu Lys Ala
             340                 345                 350        
 Leu Lys Asn Asp Ile Glu Glu Arg Ser Leu Arg Gly Asp Val Phe Phe
         355                 360                 365            
 Pro Lys Val Asn Glu Ala Gly Glu Phe Gly Leu Ile Leu Val Gln Arg
     370                 375                 380                
 Lys Ala Leu Thr Ser Lys Leu Glu His Lys Asp Leu Asn Ile Ser Val
 385                 390                 395                 400
 Asp Cys Ser Phe Asn His Gly Ile Cys Asp Trp Lys Gln Asp Arg Glu
                 405                 410                 415    
 Asp Asp Phe Asp Trp Asn Pro Ala Asp Arg Asp Asn Ala Ile Gly Phe
             420                 425                 430        
 Tyr Met Ala Val Pro Ala Leu Ala Gly His Lys Lys Asp Ile Gly Arg
         435                 440                 445            
 Leu Lys Leu Leu Leu Pro Asp Leu Gln Pro Gln Ser Asn Phe Cys Leu
     450                 455                 460                
 Leu Phe Asp Tyr Arg Leu Ala Gly Asp Lys Val Gly Lys Leu Arg Val
 465                 470                 475                 480
 Phe Val Lys Asn Ser Asn Asn Ala Leu Ala Trp Glu Lys Thr Thr Ser
                 485                 490                 495    
 Glu Asp Glu Lys Trp Lys Thr Gly Lys Ile Gln Leu Tyr Gln Gly Thr
             500                 505                 510        
 Asp Ala Thr Lys Ser Ile Ile Phe Glu Ala Glu Arg Gly Lys Gly Lys
         515                 520                 525            
 Thr Gly Glu Ile Ala Val Asp Gly Val Leu Leu Val Ser Gly Leu Cys
     530                 535                 540                
 Pro Asp Ser Leu Leu Ser Val Asp Asp
 545                 550            



      <210> 726
      <211> 693
      <212> PRT
      <213> Homo sapiens


      <400> 726
 Met Gln Gln Pro Ser His Lys Gly Thr Leu Ser Lys Val Gly Ala Glu
   1               5                  10                  15    
 Lys His Gln Ala Gly Gly Trp Thr Gly Glu Ser Trp Leu Lys Gly Leu
              20                  25                  30        
 Glu Glu Ala Arg Val Ser Glu Leu Gly Phe Glu Glu Gly Asp Cys Gln
          35                  40                  45            
 Gly Phe Val Lys Thr Thr Tyr Tyr Arg Gln Thr Glu Gly Met Ser Thr
      50                  55                  60                
 Gln Ala Arg Ala Ala Lys Glu Thr Phe Leu Val His Ser Tyr Ile Gln
  65                  70                  75                  80
 Ala Thr Asn Ile Arg Leu Gly Asn Thr Val Leu Thr Thr Phe Leu Asp
                  85                  90                  95    
 Asn Glu Ala Lys Ile Gln Gly Lys Leu Ser Cys Gln Glu Val Leu His
             100                 105                 110        
 Leu Tyr Cys Asp Thr Cys Ser Val Pro Ile Cys Arg Glu Cys Thr Met
         115                 120                 125            
 Gly Arg His Gly Gly His Ser Phe Ile Tyr Leu Gln Glu Ala Leu Gln
     130                 135                 140                
 Asp Ser Arg Ala Leu Thr Ile Gln Leu Leu Ala Asp Ala Gln Gln Gly
 145                 150                 155                 160
 Arg Gln Ala Ile Gln Leu Ser Ile Glu Gln Ala Gln Thr Val Ala Glu
                 165                 170                 175    
 Gln Val Glu Met Lys Ala Lys Val Val Gln Ser Glu Val Lys Ala Val
             180                 185                 190        
 Thr Ala Arg His Lys Lys Ala Leu Glu Glu Arg Glu Cys Glu Leu Leu
         195                 200                 205            
 Trp Lys Val Glu Lys Ile Arg Gln Val Lys Ala Lys Ser Leu Tyr Leu
     210                 215                 220                
 Gln Val Glu Lys Leu Arg Gln Asn Leu Asn Lys Leu Glu Ser Thr Ile
 225                 230                 235                 240
 Ser Ala Val Gln Gln Val Leu Glu Glu Gly Arg Ala Leu Asp Ile Leu
                 245                 250                 255    
 Leu Ala Arg Asp Arg Met Leu Ala Gln Val Gln Glu Leu Lys Thr Val
             260                 265                 270        
 Arg Ser Leu Leu Gln Pro Gln Glu Asp Asp Arg Val Met Phe Thr Pro
         275                 280                 285            
 Pro Asp Gln Ala Leu Tyr Leu Ala Ile Lys Ser Phe Gly Phe Val Ser
     290                 295                 300                
 Ser Gly Ala Phe Ala Pro Leu Thr Lys Ala Thr Gly Asp Gly Leu Lys
 305                 310                 315                 320
 Arg Ala Leu Gln Gly Lys Val Ala Ser Phe Thr Val Ile Gly Tyr Asp
                 325                 330                 335    
 His Asp Gly Glu Pro Arg Leu Ser Gly Gly Asp Leu Met Ser Ala Val
             340                 345                 350        
 Val Leu Gly Pro Asp Gly Asn Leu Phe Gly Ala Glu Val Ser Asp Gln
         355                 360                 365            
 Gln Asn Gly Thr Tyr Val Val Ser Tyr Arg Pro Gln Leu Glu Gly Glu
     370                 375                 380                
 His Leu Val Ser Val Thr Leu Cys Asn Gln His Ile Glu Asn Ser Pro
 385                 390                 395                 400
 Phe Lys Val Val Val Lys Ser Gly Arg Ser Tyr Val Gly Ile Gly Leu
                 405                 410                 415    
 Pro Gly Leu Ser Phe Gly Ser Glu Gly Asp Ser Asp Gly Lys Leu Cys
             420                 425                 430        
 Arg Pro Trp Gly Val Ser Val Asp Lys Glu Gly Tyr Ile Ile Val Ala
         435                 440                 445            
 Asp Arg Ser Asn Asn Arg Ile Gln Val Phe Lys Pro Cys Gly Ala Phe
     450                 455                 460                
 His His Lys Phe Gly Thr Leu Gly Ser Arg Pro Gly Gln Phe Asp Arg
 465                 470                 475                 480
 Pro Ala Gly Val Ala Cys Asp Ala Ser Arg Arg Ile Val Val Ala Asp
                 485                 490                 495    
 Lys Asp Asn His Arg Ile Gln Ile Phe Thr Phe Glu Gly Gln Phe Leu
             500                 505                 510        
 Leu Lys Phe Gly Glu Lys Gly Thr Lys Asn Gly Gln Phe Asn Tyr Pro
         515                 520                 525            
 Trp Asp Val Ala Val Asn Ser Glu Gly Lys Ile Leu Val Ser Asp Thr
     530                 535                 540                
 Arg Asn His Arg Ile Gln Leu Phe Gly Pro Asp Gly Val Phe Leu Asn
 545                 550                 555                 560
 Lys Tyr Gly Phe Glu Gly Ala Leu Trp Lys His Phe Asp Ser Pro Arg
                 565                 570                 575    
 Gly Val Ala Phe Asn His Glu Gly His Leu Val Val Thr Asp Phe Asn
             580                 585                 590        
 Asn His Arg Leu Leu Val Ile His Pro Asp Cys Gln Ser Ala Arg Phe
         595                 600                 605            
 Leu Gly Ser Glu Gly Thr Gly Asn Gly Gln Phe Leu Arg Pro Gln Gly
     610                 615                 620                
 Val Ala Val Asp Gln Glu Gly Arg Ile Ile Val Ala Asp Ser Arg Asn
 625                 630                 635                 640
 His Arg Val Gln Met Phe Glu Ser Asn Gly Ser Phe Leu Cys Lys Phe
                 645                 650                 655    
 Gly Ala Gln Gly Ser Gly Phe Gly Gln Met Asp Arg Pro Ser Gly Ile
             660                 665                 670        
 Ala Ile Thr Pro Asp Gly Met Ile Val Val Val Asp Phe Gly Asn Asn
         675                 680                 685            
 Arg Ile Leu Val Phe
     690            



      <210> 727
      <211> 1136
      <212> PRT
      <213> Homo sapiens


      <400> 727
 Met Phe Ser Arg Lys Lys Arg Glu Leu Met Lys Thr Pro Ser Ile Ser
   1               5                  10                  15    
 Lys Lys Asn Arg Ala Gly Ser Pro Ser Pro Gln Pro Ser Gly Glu Leu
              20                  25                  30        
 Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro Gly Pro Ser Leu Glu
          35                  40                  45            
 Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Thr Gly Thr Leu Lys Arg
      50                  55                  60                
 Pro Thr Ser Leu Ser Arg His Ala Ser Ala Ala Gly Phe Pro Leu Ser
  65                  70                  75                  80
 Gly Ala Ala Ser Trp Thr Leu Gly Arg Ser His Arg Ser Pro Leu Thr
                  85                  90                  95    
 Ala Ala Ser Pro Gly Glu Leu Pro Thr Glu Gly Ala Gly Pro Asp Val
             100                 105                 110        
 Val Glu Asp Ile Ser His Leu Leu Ala Asp Val Ala Arg Phe Ala Glu
         115                 120                 125            
 Gly Leu Glu Lys Leu Lys Glu Cys Val Leu Arg Asp Asp Leu Leu Glu
     130                 135                 140                
 Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val
 145                 150                 155                 160
 Met His Gln Ile Ile Ser Lys Tyr Pro Leu Leu Asn Thr Val Glu Thr
                 165                 170                 175    
 Leu Thr Ala Ala Gly Thr Leu Ile Ala Lys Val Lys Ala Phe His Tyr
             180                 185                 190        
 Glu Ser Asn Asn Asp Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu
         195                 200                 205            
 Thr Ile Ala Val Ala Phe Ser Ser Thr Val Ser Glu Phe Leu Met Gly
     210                 215                 220                
 Glu Val Asp Ser Ser Thr Leu Leu Ala Val Pro Pro Gly Asp Ser Ser
 225                 230                 235                 240
 Gln Ser Met Glu Ser Leu Tyr Gly Pro Gly Ser Glu Gly Thr Pro Pro
                 245                 250                 255    
 Ser Leu Asp Asp Cys Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp
             260                 265                 270        
 Val Leu Leu Gln Arg Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr
         275                 280                 285            
 Ala Lys Asn Met Ala Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu
     290                 295                 300                
 Lys Arg Thr Thr Leu Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile
 305                 310                 315                 320
 Ala His Asn Cys Arg Gln Ser Val Met Gln Glu Pro His Met Pro Leu
                 325                 330                 335    
 Leu Ser Ile Tyr Ser Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His
             340                 345                 350        
 Ser Met Val Gln Ala Val Gly Thr Leu Gln Thr Gln Thr Phe Met Gln
         355                 360                 365            
 Pro Leu Thr Leu Arg Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile
     370                 375                 380                
 Lys Glu Ala Trp His Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser
 385                 390                 395                 400
 Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His
                 405                 410                 415    
 Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly
             420                 425                 430        
 Ser Ala Pro Gly Ala Gly Gly Thr Ala Thr Lys Thr Leu Asp Lys Arg
         435                 440                 445            
 Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala
     450                 455                 460                
 Thr Tyr Arg Thr Cys Val Ala Asp Ala Lys Thr Gln Lys Gln Glu Leu
 465                 470                 475                 480
 Glu Asp Thr Lys Val Thr Ala Leu Arg Gln Ile Gln Glu Val Ile Arg
                 485                 490                 495    
 Gln Ser Asp Gln Thr Ile Lys Ser Ala Thr Ile Ser Tyr Tyr Gln Met
             500                 505                 510        
 Met His Met Gln Thr Ala Pro Leu Pro Val His Phe Gln Met Leu Cys
         515                 520                 525            
 Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val
     530                 535                 540                
 Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu
 545                 550                 555                 560
 Pro His Val Ser Ala Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys
                 565                 570                 575    
 Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser
             580                 585                 590        
 Pro Pro Glu Glu Gly Gly Cys Thr Glu Gly Thr Pro Ala Lys Asp His
         595                 600                 605            
 Arg Ala Gly Arg Gly His Gln Val His Lys Ser Trp Pro Leu Ser Ile
     610                 615                 620                
 Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe
 625                 630                 635                 640
 Lys Lys Phe Glu Arg Thr Ser Ser Ser Gly Thr Met Ser Ser Thr Glu
                 645                 650                 655    
 Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln
             660                 665                 670        
 Ala Asp Leu Asn Gly Met Thr Pro Glu Leu Pro Val Ala Val Pro Ser
         675                 680                 685            
 Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala Ala Arg Thr His Arg
     690                 695                 700                
 Leu Arg Lys Leu Arg Thr Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr
 705                 710                 715                 720
 Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His
                 725                 730                 735    
 Lys Lys Cys Leu Glu Thr Leu Ala Ile Gln Cys Gly His Lys Lys Leu
             740                 745                 750        
 Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg
         755                 760                 765            
 Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu
     770                 775                 780                
 Ile Glu Arg Arg Ala Leu Arg Thr Lys Gly Ile Tyr Arg Val Asn Gly
 785                 790                 795                 800
 Val Lys Thr Arg Val Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys
                 805                 810                 815    
 Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val
             820                 825                 830        
 Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg
         835                 840                 845            
 Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu
     850                 855                 860                
 Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser
 865                 870                 875                 880
 Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg
                 885                 890                 895    
 Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His
             900                 905                 910        
 Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn Lys Met Thr Pro Gly
         915                 920                 925            
 Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Leu Arg Pro Arg Pro Thr
     930                 935                 940                
 Glu Ala Thr Val Ser Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala
 945                 950                 955                 960
 Arg Val Ile Glu Thr Leu Ile Val His Tyr Gly Leu Val Phe Glu Glu
                 965                 970                 975    
 Glu Pro Glu Glu Thr Pro Gly Gly Gln Asp Glu Ser Ser Asn Gln Arg
             980                 985                 990        
 Ala Glu Val Val Val Gln Val Pro Tyr Leu Glu Ala Gly Glu Ala Val
         995                1000                1005            
 Val Tyr Pro Leu Gln Glu Ala Ala Ala Asp Gly Cys Arg Glu Ser Arg
    1010                1015                1020                
 Val Val Ser Asn Asp Ser Asp Ser Asp Leu Glu Glu Ala Ser Glu Leu
1025                1030                1035                1040
 Leu Ser Ser Ser Glu Ala Ser Ala Leu Gly His Leu Ser Phe Leu Glu
                1045                1050                1055    
 Gln Gln Gln Ser Glu Ala Ser Leu Glu Val Ala Ser Gly Ser His Ser
            1060                1065                1070        
 Gly Ser Glu Glu Gln Leu Glu Ala Thr Ala Arg Glu Asp Gly Asp Gly
        1075                1080                1085            
 Asp Glu Asp Gly Pro Ala Gln Gln Leu Ser Gly Phe Asn Thr Asn Gln
    1090                1095                1100                
 Ser Asn Asn Val Leu Gln Ala Pro Leu Pro Pro Met Arg Leu Arg Gly
1105                1110                1115                1120
 Gly Arg Met Thr Leu Gly Ser Cys Arg Glu Arg Gln Pro Glu Phe Val
                1125                1130                1135    





      <210> 728
      <211> 274
      <212> PRT
      <213> Homo sapiens


      <400> 728
 Met Ile Ile Ser His Phe Pro Lys Cys Val Ala Val Phe Ala Leu Leu
   1               5                  10                  15    
 Ala Leu Ser Val Gly Ala Leu Asp Thr Phe Ile Ala Ala Val Tyr Glu
              20                  25                  30        
 His Ala Val Ile Leu Pro Asn Arg Thr Glu Thr Pro Val Ser Lys Glu
          35                  40                  45            
 Glu Ala Leu Leu Leu Met Asn Lys Asn Ile Asp Val Leu Glu Lys Ala
      50                  55                  60                
 Val Lys Leu Ala Ala Lys Gln Gly Ala His Ile Ile Val Thr Pro Glu
  65                  70                  75                  80
 Asp Gly Ile Tyr Gly Trp Ile Phe Thr Arg Glu Ser Ile Tyr Pro Tyr
                  85                  90                  95    
 Leu Glu Asp Ile Pro Asp Pro Gly Val Asn Trp Ile Pro Cys Thr Asp
             100                 105                 110        
 Pro Trp Arg Phe Gly Asn Thr Pro Val Gln Gln Arg Leu Ser Cys Leu
         115                 120                 125            
 Ala Lys Asp Asn Ser Ile Tyr Val Val Ala Asn Ile Gly Asp Lys Lys
     130                 135                 140                
 Pro Cys Asn Ala Ser Asp Ser Gln Cys Pro Pro Asp Gly Arg Tyr Gln
 145                 150                 155                 160
 Tyr Asn Thr Asp Val Val Phe Asp Ser Gln Gly Lys Leu Leu Ala Arg
                 165                 170                 175    
 Tyr His Lys Tyr Asn Leu Phe Ala Pro Glu Ile Gln Phe Asp Phe Pro
             180                 185                 190        
 Lys Asp Ser Glu Leu Val Thr Phe Asp Thr Pro Phe Gly Lys Phe Gly
         195                 200                 205            
 Ile Phe Thr Cys Phe Asp Ile Phe Ser His Asp Pro Ala Ala Val Val
     210                 215                 220                
 Val Asp Glu Phe Gln Leu Thr Ala Phe Ser Thr Pro Gln His Gly Thr
 225                 230                 235                 240
 Thr Arg Cys Pro Ser Ser Arg Leu Phe Pro Ser Ile Gln His Gly Pro
                 245                 250                 255    
 Arg Pro Trp Glu Ser Ile Tyr Leu Leu Gln Ile Pro Thr Thr Pro Ala
             260                 265                 270        
 Cys Thr
        



      <210> 729
      <211> 1610
      <212> PRT
      <213> Homo sapiens


      <400> 729
 Met Gly Ser Pro Asp Ala Ala Ala Val Val Arg Lys Asp Arg Leu His
   1               5                  10                  15    
 Pro Arg Gln Val Arg Leu Leu Glu Thr Leu Ser Glu Tyr Glu Ile Val
              20                  25                  30        
 Ser Pro Ile Arg Val Asn Ala Leu Gly Glu Pro Phe Pro Thr Asn Val
          35                  40                  45            
 His Phe Lys Arg Thr Arg Arg Ser Ile Asn Ser Ala Thr Asp Pro Trp
      50                  55                  60                
 Pro Ala Phe Ala Ser Ser Ser Ser Ser Ser Thr Ser Ser Gln Ala His
  65                  70                  75                  80
 Tyr Arg Leu Ser Ala Phe Gly Gln Gln Phe Leu Phe Asn Leu Thr Ala
                  85                  90                  95    
 Asn Ala Gly Phe Ile Ala Pro Leu Phe Thr Val Thr Leu Leu Gly Thr
             100                 105                 110        
 Pro Gly Val Asn Gln Thr Lys Phe Tyr Ser Glu Glu Glu Ala Glu Leu
         115                 120                 125            
 Lys His Cys Phe Tyr Lys Gly Tyr Val Asn Thr Asn Ser Glu His Thr
     130                 135                 140                
 Ala Val Ile Ser Leu Cys Ser Gly Met Leu Gly Thr Phe Arg Ser His
 145                 150                 155                 160
 Asp Gly Asp Tyr Phe Ile Glu Pro Leu Gln Ser Met Asp Glu Gln Glu
                 165                 170                 175    
 Asp Glu Glu Glu Gln Asn Lys Pro His Ile Ile Tyr Arg Arg Ser Ala
             180                 185                 190        
 Pro Gln Arg Glu Pro Ser Thr Gly Arg His Ala Cys Asp Thr Ser Glu
         195                 200                 205            
 His Lys Asn Arg His Ser Lys Asp Lys Lys Lys Thr Arg Ala Arg Lys
     210                 215                 220                
 Trp Gly Glu Arg Ile Asn Leu Ala Gly Asp Val Ala Ala Leu Asn Ser
 225                 230                 235                 240
 Gly Leu Ala Thr Glu Ala Phe Ser Ala Tyr Gly Asn Lys Thr Asp Asn
                 245                 250                 255    
 Thr Arg Glu Lys Arg Thr His Arg Arg Thr Lys Arg Phe Leu Ser Tyr
             260                 265                 270        
 Pro Arg Phe Val Glu Val Leu Val Val Ala Asp Asn Arg Met Val Ser
         275                 280                 285            
 Tyr His Gly Glu Asn Leu Gln His Tyr Ile Leu Thr Leu Met Ser Ile
     290                 295                 300                
 Val Ala Ser Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu Ile Asn Ile
 305                 310                 315                 320
 Val Ile Val Asn Leu Ile Val Ile His Asn Glu Gln Asp Gly Pro Ser
                 325                 330                 335    
 Ile Ser Phe Asn Ala Gln Thr Thr Leu Lys Asn Phe Cys Gln Trp Gln
             340                 345                 350        
 His Ser Lys Asn Ser Pro Gly Gly Ile His His Asp Thr Ala Val Leu
         355                 360                 365            
 Leu Thr Arg Gln Asp Ile Cys Arg Ala His Asp Lys Cys Asp Thr Leu
     370                 375                 380                
 Gly Leu Ala Glu Leu Gly Thr Ile Cys Asp Pro Tyr Arg Ser Cys Ser
 385                 390                 395                 400
 Ile Ser Glu Asp Ser Gly Leu Ser Thr Ala Phe Thr Ile Ala His Glu
                 405                 410                 415    
 Leu Gly His Val Phe Asn Met Pro His Asp Asp Asn Asn Lys Cys Lys
             420                 425                 430        
 Glu Glu Gly Val Lys Ser Pro Gln His Val Met Ala Pro Thr Leu Asn
         435                 440                 445            
 Phe Tyr Thr Asn Pro Trp Met Trp Ser Lys Cys Ser Arg Lys Tyr Ile
     450                 455                 460                
 Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu Asn Glu Pro
 465                 470                 475                 480
 Glu Ser Arg Pro Tyr Pro Leu Pro Val Gln Leu Pro Gly Ile Leu Tyr
                 485                 490                 495    
 Asn Val Asn Lys Gln Cys Glu Leu Ile Phe Gly Pro Gly Ser Gln Val
             500                 505                 510        
 Cys Pro Tyr Met Met Gln Cys Arg Arg Leu Trp Cys Asn Asn Val Asn
         515                 520                 525            
 Gly Val His Lys Gly Cys Arg Thr Gln His Thr Pro Trp Ala Asp Gly
     530                 535                 540                
 Thr Glu Cys Glu Pro Gly Lys His Cys Lys Tyr Gly Phe Cys Val Pro
 545                 550                 555                 560
 Lys Glu Met Asp Val Pro Val Thr Asp Gly Ser Trp Gly Ser Trp Ser
                 565                 570                 575    
 Pro Phe Gly Thr Cys Ser Arg Thr Cys Gly Gly Gly Ile Lys Thr Ala
             580                 585                 590        
 Ile Arg Glu Cys Asn Arg Pro Glu Pro Lys Asn Gly Gly Lys Tyr Cys
         595                 600                 605            
 Val Gly Arg Arg Met Lys Phe Lys Ser Cys Asn Thr Glu Pro Cys Leu
     610                 615                 620                
 Lys Gln Lys Arg Asp Phe Arg Asp Glu Gln Cys Ala His Phe Asp Gly
 625                 630                 635                 640
 Lys His Phe Asn Ile Asn Gly Leu Leu Pro Asn Val Arg Trp Val Pro
                 645                 650                 655    
 Lys Tyr Ser Gly Ile Leu Met Lys Asp Arg Cys Lys Leu Phe Cys Arg
             660                 665                 670        
 Val Ala Gly Asn Thr Ala Tyr Tyr Gln Leu Arg Asp Arg Val Ile Asp
         675                 680                 685            
 Gly Thr Pro Cys Gly Gln Asp Thr Asn Asp Ile Cys Val Gln Gly Leu
     690                 695                 700                
 Cys Arg Gln Ala Gly Cys Asp His Val Leu Asn Ser Lys Ala Arg Arg
 705                 710                 715                 720
 Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Lys Thr Val
                 725                 730                 735    
 Ala Gly Thr Phe Asn Thr Val His Tyr Gly Tyr Asn Thr Val Val Arg
             740                 745                 750        
 Ile Pro Ala Gly Ala Thr Asn Ile Asp Val Arg Gln His Ser Phe Ser
         755                 760                 765            
 Gly Glu Thr Asp Asp Asp Asn Tyr Leu Ala Leu Ser Ser Ser Lys Gly
     770                 775                 780                
 Glu Phe Leu Leu Asn Gly Asn Phe Val Val Thr Met Ala Lys Arg Glu
 785                 790                 795                 800
 Ile Arg Ile Gly Asn Ala Val Val Glu Tyr Ser Gly Ser Glu Thr Ala
                 805                 810                 815    
 Val Glu Arg Ile Asn Ser Thr Asp Arg Ile Glu Gln Glu Leu Leu Leu
             820                 825                 830        
 Gln Val Leu Ser Val Gly Lys Leu Tyr Asn Pro Asp Val Arg Tyr Ser
         835                 840                 845            
 Phe Asn Ile Pro Ile Glu Asp Lys Pro Gln Gln Phe Tyr Trp Asn Ser
     850                 855                 860                
 His Gly Pro Trp Gln Ala Cys Ser Lys Pro Cys Gln Gly Glu Arg Lys
 865                 870                 875                 880
 Arg Lys Leu Val Cys Thr Arg Glu Ser Asp Gln Leu Thr Val Ser Asp
                 885                 890                 895    
 Gln Arg Cys Asp Arg Leu Pro Gln Pro Gly His Ile Thr Glu Pro Cys
             900                 905                 910        
 Gly Thr Asp Cys Asp Leu Arg Trp His Val Ala Ser Arg Ser Glu Cys
         915                 920                 925            
 Ser Ala Gln Cys Gly Leu Gly Tyr Arg Thr Leu Asp Ile Tyr Cys Ala
     930                 935                 940                
 Lys Tyr Ser Arg Leu Asp Gly Lys Thr Glu Lys Val Asp Asp Gly Phe
 945                 950                 955                 960
 Cys Ser Ser His Pro Lys Pro Ser Asn Arg Glu Lys Cys Ser Gly Glu
                 965                 970                 975    
 Cys Asn Thr Gly Gly Trp Arg Tyr Ser Ala Trp Thr Glu Cys Ser Lys
             980                 985                 990        
 Ser Cys Asp Gly Gly Thr Gln Arg Arg Arg Ala Ile Cys Val Asn Thr
         995                1000                1005            
 Arg Asn Asp Val Leu Asp Asp Ser Lys Cys Thr His Gln Glu Lys Val
    1010                1015                1020                
 Thr Ile Gln Arg Cys Ser Glu Phe Pro Cys Pro Gln Trp Lys Ser Gly
1025                1030                1035                1040
 Asp Trp Ser Glu Cys Leu Val Thr Cys Gly Lys Gly His Lys His Arg
                1045                1050                1055    
 Gln Val Trp Cys Gln Phe Gly Glu Asp Arg Leu Asn Asp Arg Met Cys
            1060                1065                1070        
 Asp Pro Glu Thr Lys Pro Thr Ser Met Gln Thr Cys Gln Gln Pro Glu
        1075                1080                1085            
 Cys Ala Ser Trp Gln Ala Gly Pro Trp Gly Gln Cys Ser Val Thr Cys
    1090                1095                1100                
 Gly Gln Gly Tyr Gln Leu Arg Ala Val Lys Cys Ile Ile Gly Thr Tyr
1105                1110                1115                1120
 Met Ser Val Val Asp Asp Asn Asp Cys Asn Ala Ala Thr Arg Pro Thr
                1125                1130                1135    
 Asp Thr Gln Asp Cys Glu Leu Pro Ser Cys His Pro Pro Pro Ala Ala
            1140                1145                1150        
 Pro Glu Thr Arg Arg Ser Thr Tyr Ser Ala Pro Arg Thr Gln Trp Arg
        1155                1160                1165            
 Phe Gly Ser Trp Thr Pro Cys Ser Ala Thr Cys Gly Lys Gly Thr Arg
    1170                1175                1180                
 Met Arg Tyr Val Ser Cys Arg Asp Glu Asn Gly Ser Val Ala Asp Glu
1185                1190                1195                1200
 Ser Ala Cys Ala Thr Leu Pro Arg Pro Val Ala Lys Glu Glu Cys Ser
                1205                1210                1215    
 Val Thr Pro Cys Gly Gln Trp Lys Ala Leu Asp Trp Ser Ser Cys Ser
            1220                1225                1230        
 Val Thr Cys Gly Gln Gly Arg Ala Thr Arg Gln Val Met Cys Val Asn
        1235                1240                1245            
 Tyr Ser Asp His Val Ile Asp Arg Ser Glu Cys Asp Gln Asp Tyr Ile
    1250                1255                1260                
 Pro Glu Thr Asp Gln Asp Cys Ser Met Ser Pro Cys Pro Gln Arg Thr
1265                1270                1275                1280
 Pro Asp Ser Gly Leu Ala Gln His Pro Phe Gln Asn Glu Asp Tyr Arg
                1285                1290                1295    
 Pro Arg Ser Ala Ser Pro Ser Arg Thr His Val Leu Gly Gly Asn Gln
            1300                1305                1310        
 Trp Arg Thr Gly Pro Trp Gly Ala Cys Ser Ser Thr Cys Ala Gly Gly
        1315                1320                1325            
 Ser Gln Arg Arg Val Val Val Cys Gln Asp Glu Asn Gly Tyr Thr Ala
    1330                1335                1340                
 Asn Asp Cys Val Glu Arg Ile Lys Pro Asp Glu Gln Arg Ala Cys Glu
1345                1350                1355                1360
 Ser Gly Pro Cys Pro Gln Trp Ala Tyr Gly Asn Trp Gly Glu Cys Thr
                1365                1370                1375    
 Lys Leu Cys Gly Gly Gly Ile Arg Thr Arg Leu Val Val Cys Gln Arg
            1380                1385                1390        
 Ser Asn Gly Glu Arg Phe Pro Asp Leu Ser Cys Glu Ile Leu Asp Lys
        1395                1400                1405            
 Pro Pro Asp Arg Glu Gln Cys Asn Thr His Ala Cys Pro His Asp Ala
    1410                1415                1420                
 Ala Trp Ser Thr Gly Pro Trp Ser Ser Cys Ser Val Ser Cys Gly Arg
1425                1430                1435                1440
 Gly His Lys Gln Arg Asn Val Tyr Cys Met Ala Lys Asp Gly Ser His
                1445                1450                1455    
 Leu Glu Ser Asp Tyr Cys Lys His Leu Ala Lys Pro His Gly His Arg
            1460                1465                1470        
 Lys Cys Arg Gly Gly Arg Cys Pro Lys Trp Lys Ala Gly Ala Trp Ser
        1475                1480                1485            
 Gln Cys Ser Val Ser Cys Gly Arg Gly Val Gln Gln Arg His Val Gly
    1490                1495                1500                
 Cys Gln Ile Gly Thr His Lys Ile Ala Arg Glu Thr Glu Cys Asn Pro
1505                1510                1515                1520
 Tyr Thr Arg Pro Glu Ser Glu Arg Asp Cys Gln Gly Pro Arg Cys Pro
                1525                1530                1535    
 Leu Tyr Thr Trp Arg Ala Glu Glu Trp Gln Glu Cys Thr Lys Thr Cys
            1540                1545                1550        
 Gly Glu Gly Ser Arg Tyr Arg Lys Val Val Cys Val Asp Asp Asn Lys
        1555                1560                1565            
 Asn Glu Val His Gly Ala Arg Cys Asp Val Ser Lys Arg Pro Val Asp
    1570                1575                1580                
 Arg Glu Ser Cys Ser Leu Gln Pro Cys Glu Tyr Val Trp Ile Thr Gly
1585                1590                1595                1600
 Glu Trp Ser Glu Val Pro Ser Trp Glu Leu
                1605                1610



      <210> 730
      <211> 418
      <212> PRT
      <213> Homo sapiens


      <400> 730
 Met Gly Glu Glu Gly Thr Gly Gly Thr Val His Leu Leu Cys Leu Ala
   1               5                  10                  15    
 Ala Ser Ser Gly Val Pro Leu Phe Cys Arg Ser Ser Arg Gly Gly Ala
              20                  25                  30        
 Pro Ala Arg Gln Gln Leu Pro Phe Ser Val Ile Gly Ser Leu Asn Gly
          35                  40                  45            
 Val His Met Phe Gly Gln Asn Leu Glu Val Gln Leu Ser Ser Ala Arg
      50                  55                  60                
 Thr Glu Asn Thr Thr Val Val Trp Lys Ser Phe His Asp Ser Ile Thr
  65                  70                  75                  80
 Leu Ile Val Leu Ser Ser Glu Val Gly Ile Ser Glu Leu Arg Leu Glu
                  85                  90                  95    
 Arg Leu Leu Gln Met Val Phe Gly Ala Met Val Leu Leu Val Gly Leu
             100                 105                 110        
 Glu Glu Leu Thr Asn Ile Arg Asn Val Glu Arg Leu Lys Lys Asp Leu
         115                 120                 125            
 Arg Ala Ser Tyr Cys Leu Ile Asp Ser Phe Leu Gly Asp Ser Glu Leu
     130                 135                 140                
 Ile Gly Asp Leu Thr Gln Cys Val Asp Cys Val Ile Pro Pro Glu Gly
 145                 150                 155                 160
 Ser Leu Leu Gln Glu Ala Leu Ser Gly Phe Ala Glu Ala Ala Gly Thr
                 165                 170                 175    
 Thr Phe Val Ser Leu Val Val Ser Gly Arg Val Val Ala Ala Thr Glu
             180                 185                 190        
 Gly Trp Trp Arg Leu Gly Thr Pro Glu Ala Val Leu Leu Pro Trp Leu
         195                 200                 205            
 Val Gly Ser Leu Pro Pro Gln Thr Ala Arg Asp Tyr Pro Val Tyr Leu
     210                 215                 220                
 Pro His Gly Ser Pro Thr Val Pro His Arg Leu Leu Thr Leu Thr Leu
 225                 230                 235                 240
 Leu Pro Ser Leu Glu Leu Cys Leu Leu Cys Gly Pro Ser Pro Pro Leu
                 245                 250                 255    
 Ser Gln Leu Tyr Pro Gln Leu Leu Glu Arg Trp Trp Gln Pro Leu Leu
             260                 265                 270        
 Asp Pro Leu Arg Ala Cys Leu Pro Leu Gly Pro Arg Ala Leu Pro Ser
         275                 280                 285            
 Gly Phe Pro Leu His Thr Asp Ile Leu Gly Leu Leu Leu Leu His Leu
     290                 295                 300                
 Glu Leu Lys Arg Cys Leu Phe Thr Val Glu Pro Leu Gly Asp Lys Glu
 305                 310                 315                 320
 Pro Ser Pro Glu Gln Arg Arg Arg Leu Leu Arg Asn Phe Tyr Thr Leu
                 325                 330                 335    
 Val Thr Ser Thr His Phe Pro Pro Glu Pro Gly Pro Pro Glu Lys Thr
             340                 345                 350        
 Glu Asp Glu Val Tyr Gln Ala Gln Leu Pro Arg Ala Cys Tyr Leu Val
         355                 360                 365            
 Leu Gly Thr Glu Glu Pro Gly Thr Gly Val Arg Leu Val Ala Leu Gln
     370                 375                 380                
 Leu Gly Leu Arg Arg Leu Leu Leu Leu Leu Ser Pro Gln Ser Pro Thr
 385                 390                 395                 400
 His Gly Leu Arg Ser Leu Ala Thr His Thr Leu His Ala Leu Thr Pro
                 405                 410                 415    
 Leu Leu
        



      <210> 731
      <211> 440
      <212> PRT
      <213> Homo sapiens


      <400> 731
 Met Thr Val His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg
   1               5                  10                  15    
 Thr Ser Thr Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser
              20                  25                  30        
 Val Pro Glu Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly
          35                  40                  45            
 Ile Arg Ser Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg
      50                  55                  60                
 Leu Ala Ala Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr
  65                  70                  75                  80
 Arg Met Val Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His
                  85                  90                  95    
 Cys Thr Ala Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln
             100                 105                 110        
 Ile Ala Glu Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu
         115                 120                 125            
 Ser Ser Gln Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly
     130                 135                 140                
 Pro Gly Glu Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro
 145                 150                 155                 160
 Pro Ala Gly Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro
                 165                 170                 175    
 Ala Gly Ala Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu
             180                 185                 190        
 Gly Val Gly Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met
         195                 200                 205            
 Glu Lys Val Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg
     210                 215                 220                
 Pro Gly Asp Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg
 225                 230                 235                 240
 Gly Ser Gly Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro
                 245                 250                 255    
 Leu Pro Val His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala
             260                 265                 270        
 Trp Leu Ala Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu
         275                 280                 285            
 Cys Asn Ile Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala
     290                 295                 300                
 Ser Trp Trp Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro
 305                 310                 315                 320
 Ala Gln Leu Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly
                 325                 330                 335    
 Val Arg Pro Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg
             340                 345                 350        
 Ser His Arg Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val
         355                 360                 365            
 Tyr His Cys Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp
     370                 375                 380                
 Tyr Gln Ala Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr
 385                 390                 395                 400
 Met His Ala Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly
                 405                 410                 415    
 Val Ala Leu Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys
             420                 425                 430        
 Phe Met Lys Arg Leu Arg Lys Arg
         435                 440



      <210> 732
      <211> 613
      <212> PRT
      <213> Homo sapiens


      <400> 732
 Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu
   1               5                  10                  15    
 Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val
              20                  25                  30        
 Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser
          35                  40                  45            
 Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp
      50                  55                  60                
 Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser
  65                  70                  75                  80
 Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val
                  85                  90                  95    
 Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu
             100                 105                 110        
 Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His
         115                 120                 125            
 Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val
     130                 135                 140                
 Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro
 145                 150                 155                 160
 Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val
                 165                 170                 175    
 His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr
             180                 185                 190        
 Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu
         195                 200                 205            
 Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser
     210                 215                 220                
 Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala
 225                 230                 235                 240
 Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val
                 245                 250                 255    
 Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala
             260                 265                 270        
 Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu
         275                 280                 285            
 Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln
     290                 295                 300                
 Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu
 305                 310                 315                 320
 Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly
                 325                 330                 335    
 Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala
             340                 345                 350        
 Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly
         355                 360                 365            
 Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val
     370                 375                 380                
 Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp
 385                 390                 395                 400
 Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly
                 405                 410                 415    
 Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val
             420                 425                 430        
 His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala
         435                 440                 445            
 Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile
     450                 455                 460                
 Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp
 465                 470                 475                 480
 Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu
                 485                 490                 495    
 Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro
             500                 505                 510        
 Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg
         515                 520                 525            
 Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys
     530                 535                 540                
 Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala
 545                 550                 555                 560
 Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala
                 565                 570                 575    
 Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu
             580                 585                 590        
 Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys
         595                 600                 605            
 Arg Leu Arg Lys Arg
     610            



      <210> 733
      <211> 309
      <212> PRT
      <213> Homo sapiens


      <400> 733
 Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu
   1               5                  10                  15    
 Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val
              20                  25                  30        
 Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser
          35                  40                  45            
 Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp
      50                  55                  60                
 Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser
  65                  70                  75                  80
 Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val
                  85                  90                  95    
 Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu
             100                 105                 110        
 Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His
         115                 120                 125            
 Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val
     130                 135                 140                
 Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro
 145                 150                 155                 160
 Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val
                 165                 170                 175    
 His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr
             180                 185                 190        
 Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu
         195                 200                 205            
 Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser
     210                 215                 220                
 Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala
 225                 230                 235                 240
 Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Pro Arg Gly Ala
                 245                 250                 255    
 Leu Gly Thr Ala Val Gln Cys Val Arg Gly Thr Ser Pro Ser Arg Pro
             260                 265                 270        
 Ser Cys Cys Ile Leu Cys Arg Leu Gly Asp Gly Thr Cys Gly Gly Thr
         275                 280                 285            
 Trp Ala Arg Pro Pro Gly Ser Pro Ala Gly His Arg Gly Cys Gly Gln
     290                 295                 300                
 Pro Gly Pro Trp Leu
 305                



      <210> 734
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 734
 Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu
   1               5                  10                  15    
 Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val
              20                  25                  30        
 Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser
          35                  40                  45            
 Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp
      50                  55                  60                
 Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser
  65                  70                  75                  80
 Thr Lys Asp Thr Gln Phe Ser Tyr Ala Glu Arg Leu Ala Ala Gly Glu
                  85                  90                  95    
 Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val Val Gly
             100                 105                 110        
 Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala Ala Glu
         115                 120                 125            
 Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu Lys Arg
     130                 135                 140                
 Ala Val Leu Ala His Val Asp Val Gln Thr Leu Cys Lys Cys His Leu
 145                 150                 155                 160
 Tyr Ile Pro Leu Trp Glu Leu Gly Gly Thr Val Ser Trp Trp Ala Leu
                 165                 170                 175    
 Trp Pro Gln Gly Val Pro Asp Ser His His Leu Thr Pro Arg Asn Ser
             180                 185                 190        
 Ser Ser Thr Glu
         195    



      <210> 735
      <211> 339
      <212> PRT
      <213> Homo sapiens


      <400> 735
 Met Lys Ala Phe Gly Pro Pro His Glu Gly Pro Leu Gln Gly Leu Val
   1               5                  10                  15    
 Ala Ser Arg Ile Glu Thr Tyr Gly Gly Arg His Arg Ala Ser Ala Gln
              20                  25                  30        
 Ser Thr Thr Gly Arg Leu Tyr Pro Arg Gly Tyr Pro Val Leu Asp Pro
          35                  40                  45            
 Ser Arg Arg Arg Leu Gln Gln Tyr Val Pro Phe Ala Arg Gly Ser Gly
      50                  55                  60                
 Gln Ala Arg Gly Leu Ser Pro Met Arg Leu Arg Asp Pro Glu Pro Glu
  65                  70                  75                  80
 Lys Arg His Gly Gly His Val Gly Ala Gly Leu Leu His Ser Pro Lys
                  85                  90                  95    
 Leu Lys Glu Leu Thr Lys Ala His Glu Leu Glu Val Arg Leu His Thr
             100                 105                 110        
 Phe Ser Met Phe Gly Met Pro Arg Leu Pro Pro Glu Asp Arg Arg His
         115                 120                 125            
 Trp Glu Ile Gly Glu Gly Gly Asp Ser Gly Leu Thr Ile Glu Lys Ser
     130                 135                 140                
 Trp Arg Glu Leu Val Pro Gly His Lys Glu Met Ser Gln Glu Leu Cys
 145                 150                 155                 160
 His Gln Gln Glu Ala Leu Trp Glu Leu Leu Thr Thr Glu Leu Ile Tyr
                 165                 170                 175    
 Val Arg Lys Leu Lys Ile Met Thr Asp Leu Leu Ala Ala Gly Leu Leu
             180                 185                 190        
 Asn Leu Gln Arg Val Gly Leu Leu Met Glu Val Ser Ala Glu Thr Leu
         195                 200                 205            
 Phe Gly Asn Val Pro Ser Leu Ile Arg Thr His Arg Ser Phe Trp Asp
     210                 215                 220                
 Glu Val Leu Gly Pro Thr Leu Glu Glu Thr Arg Ala Ser Gly Gln Pro
 225                 230                 235                 240
 Leu Asp Pro Ile Gly Leu Gln Ser Gly Phe Leu Thr Phe Gly Gln Arg
                 245                 250                 255    
 Phe His Pro Tyr Val Gln Tyr Cys Leu Arg Val Lys Gln Thr Met Ala
             260                 265                 270        
 Tyr Ala Arg Glu Gln Gln Glu Thr Asn Pro Leu Phe His Ala Phe Val
         275                 280                 285            
 Gln Trp Cys Glu Lys His Lys Arg Ser Gly Arg Gln Met Leu Cys Asp
     290                 295                 300                
 Leu Leu Ile Lys Pro His Gln Arg Ile Thr Lys Tyr Pro Leu Leu Leu
 305                 310                 315                 320
 His Ala Val Leu Lys Arg Ser Pro Glu Ala Arg Ala Gln Glu Ala Leu
                 325                 330                 335    
 Asn Ala Ile
            



      <210> 736
      <211> 668
      <212> PRT
      <213> Homo sapiens


      <400> 736
 Met Thr Cys Pro Pro Thr Gly Leu Tyr Gly Pro Glu Gly Ile Leu Pro
   1               5                  10                  15    
 Ala Arg Arg Thr Leu Arg Pro Gln Gly Lys Gly Arg Trp Gln Gln Leu
              20                  25                  30        
 Trp Glu Thr Pro Thr Leu Leu Trp Glu Ala Pro Arg Leu Gly Leu Asp
          35                  40                  45            
 Thr Ala Gln Gly Leu Glu Leu Leu Ser Leu Leu Gly Ala Leu Val Ala
      50                  55                  60                
 Leu Gly Ala Leu Leu Leu Ser Pro Leu Arg His Pro Val Ile Tyr Leu
  65                  70                  75                  80
 Leu Leu Trp Ala Ala Tyr Leu Asp Ser Leu Leu Leu Glu Thr Gly Phe
                  85                  90                  95    
 Leu Ala Val Leu Val Ala Pro Leu Arg Pro Ala Ser His Arg Lys Glu
             100                 105                 110        
 Ala Pro Gln Gly Arg Gln Ala Gly Ala Leu Pro His Glu Asp Leu Pro
         115                 120                 125            
 Phe Trp Leu Val Arg Trp Leu Leu Phe Arg Leu Met Phe Ala Ser Gly
     130                 135                 140                
 Val Val Lys Leu Thr Ser Arg Cys Pro Ala Trp Trp Gly Leu Thr Ala
 145                 150                 155                 160
 Leu Thr Tyr His Tyr Glu Thr Gln Cys Leu Pro Thr Pro Ala Ala Trp
                 165                 170                 175    
 Phe Ala His His Leu Pro Val Trp Leu His Lys Leu Ser Val Val Ala
             180                 185                 190        
 Thr Phe Leu Ile Glu Ile Ala Val Pro Pro Leu Phe Phe Ala Pro Ile
         195                 200                 205            
 Arg Arg Leu Arg Leu Ala Ala Phe Tyr Ser Gln Val Leu Leu Gln Val
     210                 215                 220                
 Leu Ile Ile Ile Thr Gly Asn Tyr Asn Phe Phe Asn Leu Met Thr Leu
 225                 230                 235                 240
 Val Leu Thr Thr Ala Leu Leu Asp Asp Gln His Leu Ala Ala Glu Pro
                 245                 250                 255    
 Gly His Gly Ser Arg Lys Lys Thr Ala Thr Ser Trp Pro Lys Ala Leu
             260                 265                 270        
 Leu Ala Thr Leu Ser Leu Leu Leu Glu Leu Ala Val Tyr Gly Leu Leu
         275                 280                 285            
 Ala Tyr Gly Thr Val His Tyr Phe Gly Leu Glu Val Asp Trp Gln Gln
     290                 295                 300                
 Arg Thr Ile His Ser Arg Thr Thr Phe Thr Phe His Gln Phe Ser Gln
 305                 310                 315                 320
 Trp Leu Lys Thr Leu Thr Leu Pro Thr Val Trp Leu Gly Val Ala Ser
                 325                 330                 335    
 Leu Val Trp Glu Leu Leu Ser Ala Leu Trp Arg Trp Thr Gln Val Arg
             340                 345                 350        
 Gly Trp Leu Arg Lys Leu Ser Ala Val Val Gln Leu Ser Leu Val Gly
         355                 360                 365            
 Thr Ala Thr Val Ala Leu Phe Leu Ile Ser Leu Val Pro Tyr Ser Tyr
     370                 375                 380                
 Val Glu Pro Gly Thr His Gly Arg Leu Trp Thr Gly Ala His Arg Leu
 385                 390                 395                 400
 Phe Gly Ala Val Glu His Leu Gln Leu Ala Asn Ser Tyr Gly Leu Phe
                 405                 410                 415    
 Arg Arg Met Thr Gly Leu Gly Gly Arg Pro Glu Val Val Leu Glu Gly
             420                 425                 430        
 Ser Tyr Asp Gly His His Trp Thr Glu Ile Glu Phe Met Tyr Lys Pro
         435                 440                 445            
 Gly Asn Leu Ser Arg Pro Pro Pro Val Val Val Pro His Gln Pro Arg
     450                 455                 460                
 Leu Asp Trp Gln Met Trp Phe Ala Ala Leu Gly Pro His Thr His Ser
 465                 470                 475                 480
 Pro Trp Phe Thr Ser Leu Val Leu Arg Leu Leu Gln Gly Lys Glu Pro
                 485                 490                 495    
 Val Ile Arg Leu Val Gln Ser Gln Val Ala Arg Tyr Pro Phe His Lys
             500                 505                 510        
 Gln Pro Pro Thr Tyr Val Arg Ala Gln Arg Tyr Lys Tyr Trp Phe Ser
         515                 520                 525            
 Gln Pro Gly Glu Gln Gly Gln Trp Trp Arg Arg Gln Trp Val Glu Glu
     530                 535                 540                
 Phe Phe Pro Ser Val Ser Leu Gly Asp Pro Thr Leu Glu Thr Leu Leu
 545                 550                 555                 560
 Arg Gln Phe Gly Leu Gln Glu Lys Ser Pro Pro Arg Thr Arg Ser Ala
                 565                 570                 575    
 Asn Ser Thr Leu Ala Gln Ala Leu His Trp Thr Arg Ser Gln Leu Ser
             580                 585                 590        
 Pro Leu Glu Ala Pro Ala Leu Leu Trp Gly Leu Leu Met Ala Val Gly
         595                 600                 605            
 Ala Val Arg Phe Val Gln Ala Leu Leu Ala Pro Cys Ser Leu Arg Ser
     610                 615                 620                
 Ser Pro Leu Ala Pro Val Ser Gly Glu Lys Arg Arg Pro Ala Ser Gln
 625                 630                 635                 640
 Lys Asp Ser Gly Ala Ala Ser Glu Gln Ala Thr Ala Ala Pro Asn Pro
                 645                 650                 655    
 Cys Ser Ser Ser Ser Arg Thr Thr Arg Arg Lys Lys
             660                 665            



      <210> 737
      <211> 756
      <212> PRT
      <213> Homo sapiens


      <400> 737
 Met Pro Leu Arg Pro Gly Ser Leu Val Pro Glu Gly Ala Gly Phe Pro
   1               5                  10                  15    
 Lys Met Ala Ala Asp Val Ser Val Thr His Arg Pro Pro Leu Ser Pro
              20                  25                  30        
 Lys Ser Gly Ala Glu Val Glu Ala Gly Asp Ala Ala Glu Arg Arg Ala
          35                  40                  45            
 Pro Glu Glu Glu Leu Pro Pro Leu Asp Pro Glu Glu Ile Arg Lys Arg
      50                  55                  60                
 Leu Glu His Thr Glu Arg Gln Phe Arg Asn Arg Arg Lys Ile Leu Ile
  65                  70                  75                  80
 Arg Gly Leu Pro Gly Asp Val Thr Asn Gln Glu Val His Asp Leu Leu
                  85                  90                  95    
 Ser Asp Tyr Glu Leu Lys Tyr Cys Phe Val Asp Lys Tyr Lys Gly Thr
             100                 105                 110        
 Ala Phe Val Thr Leu Leu Asn Gly Glu Gln Ala Glu Ala Ala Ile Asn
         115                 120                 125            
 Ala Phe His Gln Ser Arg Leu Arg Glu Arg Glu Leu Ser Val Gln Leu
     130                 135                 140                
 Gln Pro Thr Asp Ala Leu Leu Cys Val Ala Asn Leu Pro Pro Ser Leu
 145                 150                 155                 160
 Thr Gln Gln Gln Phe Glu Glu Leu Val Arg Pro Phe Gly Ser Leu Glu
                 165                 170                 175    
 Arg Cys Phe Leu Val Tyr Ser Glu Arg Thr Gly Gln Ser Lys Gly Tyr
             180                 185                 190        
 Gly Phe Ala Glu Tyr Met Lys Lys Asp Ser Ala Ala Arg Ala Lys Ser
         195                 200                 205            
 Asp Leu Leu Gly Lys Pro Leu Gly Pro Arg Thr Leu Tyr Val His Trp
     210                 215                 220                
 Thr Asp Ala Gly Gln Leu Thr Pro Ala Leu Leu His Ser Arg Cys Leu
 225                 230                 235                 240
 Cys Val Asp Arg Leu Pro Pro Gly Phe Asn Asp Val Asp Ala Leu Cys
                 245                 250                 255    
 Arg Ala Leu Ser Ala Val His Ser Pro Thr Phe Cys Gln Leu Ala Cys
             260                 265                 270        
 Gly Gln Asp Gly Gln Leu Lys Gly Phe Ala Val Leu Glu Tyr Glu Thr
         275                 280                 285            
 Ala Glu Met Ala Glu Glu Ala Gln Gln Gln Ala Asp Gly Leu Ser Leu
     290                 295                 300                
 Gly Gly Ser His Leu Arg Val Ser Phe Cys Ala Pro Gly Pro Pro Gly
 305                 310                 315                 320
 Arg Ser Met Leu Ala Ala Leu Ile Ala Ala Gln Ala Thr Ala Leu Asn
                 325                 330                 335    
 Arg Gly Lys Gly Leu Leu Pro Glu Pro Asn Ile Leu Gln Leu Leu Asn
             340                 345                 350        
 Asn Leu Gly Pro Ser Ala Ser Leu Gln Leu Leu Leu Asn Pro Leu Leu
         355                 360                 365            
 His Gly Ser Ala Gly Gly Lys Gln Gly Leu Leu Gly Ala Pro Pro Ala
     370                 375                 380                
 Met Pro Leu Leu Asn Gly Pro Ala Leu Ser Thr Ala Leu Leu Gln Leu
 385                 390                 395                 400
 Ala Leu Gln Thr Gln Gly Gln Lys Lys Pro Gly Ile Leu Gly Asp Ser
                 405                 410                 415    
 Pro Leu Gly Ala Leu Gln Pro Gly Ala Gln Pro Ala Asn Pro Leu Leu
             420                 425                 430        
 Gly Glu Leu Pro Ala Gly Gly Gly Leu Pro Pro Glu Leu Pro Pro Arg
         435                 440                 445            
 Arg Gly Lys Pro Pro Pro Leu Leu Pro Ser Val Leu Gly Pro Ala Gly
     450                 455                 460                
 Gly Asp Arg Glu Ala Leu Gly Leu Gly Pro Pro Ala Ala Gln Leu Thr
 465                 470                 475                 480
 Pro Pro Pro Ala Pro Val Gly Leu Arg Gly Ser Gly Leu Arg Gly Leu
                 485                 490                 495    
 Gln Lys Asp Ser Gly Pro Leu Pro Thr Pro Pro Gly Val Ser Leu Leu
             500                 505                 510        
 Gly Glu Pro Pro Lys Asp Tyr Arg Ile Pro Leu Asn Pro Tyr Leu Asn
         515                 520                 525            
 Leu His Ser Leu Leu Pro Ala Ser Asn Leu Ala Gly Lys Glu Ala Arg
     530                 535                 540                
 Gly Trp Gly Gly Ala Gly Arg Ser Arg Arg Pro Ala Glu Gly Pro Pro
 545                 550                 555                 560
 Thr Asn Pro Pro Ala Pro Gly Gly Gly Ser Ser Ser Ser Lys Ala Phe
                 565                 570                 575    
 Gln Leu Lys Ser Arg Leu Leu Ser Pro Leu Ser Ser Ala Arg Leu Pro
             580                 585                 590        
 Pro Glu Pro Gly Leu Ser Asp Ser Tyr Ser Phe Asp Tyr Pro Ser Asp
         595                 600                 605            
 Met Gly Pro Arg Arg Leu Phe Ser His Pro Arg Glu Pro Ala Leu Gly
     610                 615                 620                
 Pro His Gly Pro Ser Arg His Lys Met Ser Pro Pro Pro Ser Gly Phe
 625                 630                 635                 640
 Gly Glu Arg Ser Ser Gly Gly Ser Gly Gly Gly Pro Leu Ser His Phe
                 645                 650                 655    
 Tyr Ser Gly Ser Pro Thr Ser Tyr Phe Thr Ser Gly Leu Gln Ala Gly
             660                 665                 670        
 Leu Lys Gln Ser His Leu Ser Lys Ala Ile Gly Ser Ser Pro Leu Gly
         675                 680                 685            
 Ser Gly Glu Gly Leu Leu Gly Leu Ser Pro Gly Pro Asn Gly His Ser
     690                 695                 700                
 His Leu Leu Lys Thr Pro Leu Gly Gly Gln Lys Arg Ser Phe Ala His
 705                 710                 715                 720
 Leu Leu Pro Ser Pro Glu Pro Ser Pro Glu Gly Ser Tyr Val Gly Gln
                 725                 730                 735    
 His Ser Gln Gly Leu Gly Gly His Tyr Ala Asp Ser Tyr Leu Lys Arg
             740                 745                 750        
 Lys Arg Ile Phe
         755    



      <210> 738
      <211> 80
      <212> PRT
      <213> Homo sapiens


      <400> 738
 Met Gln Arg Gln Arg Arg Gln Pro Ser Leu Arg Gly Leu Lys Ser Arg
   1               5                  10                  15    
 Arg Lys Pro Arg Cys Phe Pro Gln Pro Trp Thr Ile Leu Gln Asp Ser
              20                  25                  30        
 Phe Phe Thr Leu Ser Thr Cys Leu Val Arg Leu His Arg Thr Val Val
          35                  40                  45            
 Tyr Cys Pro Pro Leu Leu Thr Ser Ser Phe Ser Leu Ala Leu Ser Val
      50                  55                  60                
 Phe Leu Phe Ser Pro Ser Ser Leu Pro Leu Ala Ile Thr Ser Gly Lys
  65                  70                  75                  80





      <210> 739
      <211> 292
      <212> PRT
      <213> Homo sapiens


      <400> 739
 Met Ala Leu Ser Leu Glu Glu Phe Val His Ser Leu Asp Leu Arg Thr
   1               5                  10                  15    
 Leu Pro Arg Val Leu Glu Ile Gln Ala Gly Ile Tyr Leu Glu Gly Ser
              20                  25                  30        
 Ile Tyr Glu Met Phe Gly Asn Glu Cys Cys Phe Ser Thr Gly Glu Val
          35                  40                  45            
 Ile Lys Ile Thr Gly Leu Lys Val Lys Lys Ile Ile Ala Glu Ile Cys
      50                  55                  60                
 Glu Gln Ile Glu Gly Cys Glu Ser Leu Gln Pro Phe Glu Leu Pro Met
  65                  70                  75                  80
 Asn Phe Pro Gly Thr Phe Val Lys Arg Ser Lys Glu Cys Leu Phe Lys
                  85                  90                  95    
 Ile Val Ala Asp Lys Thr Pro Tyr Leu Thr Met Glu Glu Ile Thr Arg
             100                 105                 110        
 Thr Ile His Ile Gly Pro Ser Arg Leu Gly His Pro Cys Phe Tyr His
         115                 120                 125            
 Gln Lys Asp Ile Lys Leu Glu Asn Leu Ile Ile Lys Gln Gly Glu Gln
     130                 135                 140                
 Ile Met Leu Asn Ser Val Glu Glu Ile Asp Gly Glu Ile Met Val Ser
 145                 150                 155                 160
 Cys Ala Val Ala Arg Asn His Gln Thr His Ser Phe Asn Leu Pro Leu
                 165                 170                 175    
 Ser Gln Glu Gly Glu Phe Tyr Glu Cys Glu Asp Glu Arg Ile Tyr Thr
             180                 185                 190        
 Leu Lys Glu Ile Val Glu Trp Lys Ile Pro Lys Asn Arg Thr Arg Thr
         195                 200                 205            
 Val Asn Leu Thr Asp Phe Ser Asn Lys Trp Asp Ser Thr Asn Pro Phe
     210                 215                 220                
 Pro Lys Asp Phe Tyr Gly Thr Leu Ile Leu Lys Pro Val Tyr Glu Ile
 225                 230                 235                 240
 Gln Gly Val Met Lys Cys Glu Tyr Pro Leu Arg Met Met Phe Tyr Glu
                 245                 250                 255    
 His Glu His Tyr Gly Val Trp Glu Arg Lys Ile Leu Glu Pro Glu Glu
             260                 265                 270        
 Trp Glu Ser Val Phe Ile Ser Thr Ile Glu Pro Val Arg Val Arg Phe
         275                 280                 285            
 Leu Ile Asn Gln
     290        



      <210> 740
      <211> 376
      <212> PRT
      <213> Homo sapiens


      <400> 740
 Met Ala Arg Gly Pro Gly Pro Leu Gly Arg Pro Arg Pro Asp Thr Val
   1               5                  10                  15    
 Ala Met Pro Lys Arg Gly Lys Arg Leu Lys Phe Arg Ala His Asp Ala
              20                  25                  30        
 Cys Ser Gly Arg Val Thr Val Ala Asp Tyr Ala Asn Ser Asp Pro Ala
          35                  40                  45            
 Val Val Arg Ser Gly Arg Val Lys Lys Ala Val Ala Asn Ala Val Gln
      50                  55                  60                
 Gln Glu Val Lys Ser Leu Cys Gly Leu Glu Ala Ser Gln Val Pro Ala
  65                  70                  75                  80
 Glu Glu Ala Leu Ser Gly Ala Gly Glu Pro Cys Asp Ile Ile Asp Ser
                  85                  90                  95    
 Ser Asp Glu Met Asp Ala Gln Glu Glu Ser Ile His Glu Arg Thr Val
             100                 105                 110        
 Ser Arg Lys Lys Lys Ser Lys Arg His Lys Glu Glu Leu Asp Gly Ala
         115                 120                 125            
 Gly Gly Glu Glu Tyr Pro Met Asp Ile Trp Leu Leu Leu Ala Ser Tyr
     130                 135                 140                
 Ile Arg Pro Glu Asp Ile Val Asn Phe Ser Leu Ile Cys Lys Asn Ala
 145                 150                 155                 160
 Trp Thr Val Thr Cys Thr Ala Ala Phe Trp Thr Arg Leu Tyr Arg Arg
                 165                 170                 175    
 His Tyr Thr Leu Asp Ala Ser Leu Pro Leu Arg Leu Arg Pro Glu Ser
             180                 185                 190        
 Met Glu Lys Leu Arg Cys Leu Arg Ala Cys Val Ile Arg Ser Leu Tyr
         195                 200                 205            
 His Met Tyr Glu Pro Phe Ala Ala Arg Ile Ser Lys Asn Pro Ala Ile
     210                 215                 220                
 Pro Glu Ser Thr Pro Ser Thr Leu Lys Asn Ser Lys Cys Leu Leu Phe
 225                 230                 235                 240
 Trp Cys Arg Lys Ile Val Gly Asn Arg Gln Glu Pro Met Trp Glu Phe
                 245                 250                 255    
 Asn Phe Lys Phe Lys Lys Gln Ser Pro Arg Leu Lys Ser Lys Cys Thr
             260                 265                 270        
 Gly Gly Leu Gln Pro Pro Val Gln Tyr Glu Asp Val His Thr Asn Pro
         275                 280                 285            
 Asp Gln Asp Cys Cys Leu Leu Gln Val Thr Thr Leu Asn Phe Ile Phe
     290                 295                 300                
 Ile Pro Ile Val Met Gly Met Ile Phe Thr Leu Phe Thr Ile Asn Val
 305                 310                 315                 320
 Ser Thr Asp Met Arg His His Arg Val Arg Leu Val Phe Gln Asp Ser
                 325                 330                 335    
 Pro Val His Gly Gly Arg Lys Leu Arg Ser Glu Gln Gly Val Gln Val
             340                 345                 350        
 Ile Leu Asp Pro Val His Ser Val Arg Leu Phe Asp Trp Trp His Pro
         355                 360                 365            
 Gln Tyr Pro Phe Ser Leu Arg Ala
     370                 375    



      <210> 741
      <211> 1127
      <212> PRT
      <213> Homo sapiens


      <400> 741
 Met Val Leu Leu Gly Ser Glu Asp Thr Ile Leu Ser Asn Lys Gln Ser
   1               5                  10                  15    
 Leu Leu Val Pro Val Pro Glu Asp Leu Pro Tyr Ala Cys Thr Leu Pro
              20                  25                  30        
 Asp Pro Met Phe Ala Ile Gly Thr Gln Arg Glu Ser Cys Cys Pro Gly
          35                  40                  45            
 Cys Asp Asp Val Leu Leu Glu Ala Ser Ile Gln Gln Thr Gly Asn His
      50                  55                  60                
 Arg Ala Arg Thr Lys Glu Val Met Trp Trp Gln Ala Arg Tyr Ala Phe
  65                  70                  75                  80
 Arg Asn Glu Leu Leu Asn Ser Thr Leu His Glu Val Leu Leu Gly Met
                  85                  90                  95    
 Leu Gly Met Asn Ile Thr Ala Thr Val Arg Arg Phe Gly Cys Val Lys
             100                 105                 110        
 Trp Arg Val Ile Tyr Ala Leu Asn Thr Arg Gln Asp Glu Ala Glu Ala
         115                 120                 125            
 Ser Met Glu Ala Leu Arg Glu Ala His Gln Glu Glu Leu Gln Asn Ala
     130                 135                 140                
 Val Ala Glu Thr Lys Ala Arg Leu Leu Gln Glu Gln Gly Cys Ala Glu
 145                 150                 155                 160
 Glu Glu Ala Leu Leu Gln Arg Ile Gln Ala Leu Glu Ser Ala Leu Glu
                 165                 170                 175    
 Leu Gln Lys Arg Leu Thr Glu Glu Ala Leu Ala Glu Ser Ala Ser Cys
             180                 185                 190        
 Arg Leu Glu Thr Lys Glu Arg Glu Leu Arg Val Glu Ala Glu His Ala
         195                 200                 205            
 Glu Arg Val Leu Thr Leu Ser Arg Glu Met Leu Glu Leu Lys Ala Asp
     210                 215                 220                
 Tyr Glu Arg Arg Leu Gln His Leu Thr Ser His Glu Ala Thr Pro Gln
 225                 230                 235                 240
 Gly Arg Leu Pro Gln Glu Ser Pro Glu Thr Lys Ser Glu Pro Gly Gln
                 245                 250                 255    
 Gly Pro Glu Met Gln Glu Val Leu Leu Glu Val Gln Arg Leu Arg Val
             260                 265                 270        
 Glu Asn Gln Gln Leu Ser Lys Asp Tyr Ala Arg Lys Ala Glu Glu Leu
         275                 280                 285            
 Gln Ala Thr Tyr Glu Arg Glu Asn Glu Ala Ile Arg Gln Ala Met Gln
     290                 295                 300                
 Gln Ser Val Ser Gln Ala Leu Trp Gln Trp Gln Glu Lys Glu Ser Asp
 305                 310                 315                 320
 Leu Arg Lys Asn Phe Gln Val Gln Glu Ser Ala Leu Gln Ala Gln Val
                 325                 330                 335    
 Arg Lys Leu Glu Gly Asp Leu Glu His Arg Gly Arg Lys Ile Ser Asp
             340                 345                 350        
 Leu Lys Lys Tyr Ala Gln Lys Leu Lys Glu Arg Ile Gln Asp Leu Asp
         355                 360                 365            
 Val Gln Leu Lys Glu Ala Arg Gln Glu Asn Ser Glu Leu Lys Gly Thr
     370                 375                 380                
 Ala Lys Lys Leu Gly Glu Lys Leu Ala Val Ala Lys Asp Arg Met Met
 385                 390                 395                 400
 Leu Gln Glu Cys Arg Gly Thr Gln Gln Thr Asp Ala Met Lys Thr Glu
                 405                 410                 415    
 Leu Val Ser Glu Asn Lys Val Leu Arg Glu Glu Asn Asp Leu Glu Ala
             420                 425                 430        
 Gly Asn Leu His Pro Gln Gln Asp Gln Ser Cys Leu Lys Glu Cys Pro
         435                 440                 445            
 Cys Met Lys Gly Gly Thr Asp Met Gln Thr Lys Lys Glu Ala Ser Ala
     450                 455                 460                
 Glu Thr Glu Tyr Met Lys Gln Gln Tyr Glu Glu Asp Leu Arg Lys Ile
 465                 470                 475                 480
 Lys His Gln Thr Glu Glu Glu Lys Lys His Leu Lys Asp Gln Leu Val
                 485                 490                 495    
 Lys Arg Leu Glu Asp Leu Val Lys Lys His Thr Val Glu Ile Lys Ser
             500                 505                 510        
 Val Arg Ser Ser Val Glu Ala Glu Arg Lys Lys Leu Gln Arg Glu Val
         515                 520                 525            
 Glu Ala Gln Leu Glu Glu Val Arg Lys Lys Ser Glu Lys Glu Ile Lys
     530                 535                 540                
 Gln Leu Glu Glu Glu Lys Ala Ala Leu Asn Val Lys Leu Gln Asn Ser
 545                 550                 555                 560
 Leu Leu Glu Val Leu Arg Leu Glu Glu Phe Ile Gln Gln Asn Lys Thr
                 565                 570                 575    
 Arg Pro Thr Gly Ala Glu Glu Ser Pro Gln Glu Leu Gly Arg Gln His
             580                 585                 590        
 Cys Ser Ile Leu Glu Thr Gln Asp Pro Cys Leu Lys Leu Asp Glu Thr
         595                 600                 605            
 Ser Pro Arg Gly Glu Glu Tyr Gln Asp Lys Leu Ala Ala Glu Glu Gly
     610                 615                 620                
 Thr Ser Ser Asp Glu Glu Glu Arg Thr Lys Val Leu Leu Lys Glu Gly
 625                 630                 635                 640
 Ser Asp Pro Gln Pro Pro Leu Gly Ser Leu Leu Lys Glu Lys Thr Ser
                 645                 650                 655    
 Lys Ile Gln Arg Leu Glu Glu Asp Trp Gln Ser Gln Lys Ala Lys Leu
             660                 665                 670        
 Gln Ala Gln Val Ser Gln Met Gln Gln Ala Leu Glu Gln Cys Thr Ser
         675                 680                 685            
 Asn Tyr Arg Glu Asp Leu Gln Ala Leu Lys Gln Leu Ser Asp Leu Glu
     690                 695                 700                
 Arg Glu Lys Leu Gln Arg Glu Leu Gln Glu Thr Thr Gln Gln Asn His
 705                 710                 715                 720
 Ala Met Lys Ala Gln Leu Glu Ala Ser His Gln Arg Ala Leu Arg Met
                 725                 730                 735    
 Leu Glu Lys Ala Arg His Gln Glu Leu Lys Ala Thr Glu Glu Arg Leu
             740                 745                 750        
 Lys Lys Glu Ser Ser His Ser Leu Gln Ile Gln His Gln Thr His Arg
         755                 760                 765            
 Leu Glu Leu Gln Ala Leu Glu Glu Lys Ala Arg Gln Glu Leu Gln Glu
     770                 775                 780                
 Glu Arg Glu Arg Met Gln Ala Gln Gln Ala Leu Leu Leu Glu Ser Leu
 785                 790                 795                 800
 Arg Gln Glu Leu Ser Glu Gln Gln Ala Ala Cys Ser Gly His Gln Lys
                 805                 810                 815    
 Asp Leu Glu Ala Leu Gln Ala Glu Leu Arg Ala Leu Gly Arg Gln Gln
             820                 825                 830        
 Ala Ser Ser Gln Cys Pro Gly Asp Ser Lys Asp His Ile Ile Ala Thr
         835                 840                 845            
 Glu Glu Trp Gly Gly Pro Gly Gln Ala Gly Ser Pro Pro Gly Ala Ala
     850                 855                 860                
 Gly Gln Gly Ser Gly Glu Gly Cys Gly Leu Trp Glu Glu Asn Ala Gln
 865                 870                 875                 880
 Leu Gln Asp Ala Val Arg Arg Leu Arg Ala Glu Val Glu Gln His Gln
                 885                 890                 895    
 Gln Glu Ala Gln Lys Leu Arg Asp Gln Arg Arg Phe Leu Glu Glu Thr
             900                 905                 910        
 Gln Gln Ala Gln Arg Ala Arg Glu Val Glu Thr Leu Arg Gln Glu His
         915                 920                 925            
 Arg Lys Glu Met Gln Ala Met Val Ala Asp Phe Ser Ser Ala Gln Ala
     930                 935                 940                
 Gln Leu Gln Ala Arg Leu Ala Ala Leu Glu Ala Glu Leu Lys Asp Ser
 945                 950                 955                 960
 Gly Glu Lys Pro Gly Lys Gly Ala Ser Arg Pro Glu Asp Leu Gln Leu
                 965                 970                 975    
 Ile Gly Arg Leu Gln Thr Arg Leu Lys Glu Arg Glu Asp Ile Ile Lys
             980                 985                 990        
 Gln Leu Thr Glu Glu Arg Arg Phe His Tyr Ala Ala Phe Pro Ser Ala
         995                1000                1005            
 Met Ser His Arg Asn Arg Ser Phe Ser Phe Asn Pro His Pro Gly Tyr
    1010                1015                1020                
 Leu Thr Pro Ser Met Lys Lys Lys Lys Val Glu Asp Val Pro Ser Arg
1025                1030                1035                1040
 Val Val Ser Val Pro Asn Leu Ala Ser Tyr Ala Lys Asn Phe Leu Ser
                1045                1050                1055    
 Gly Asp Leu Ser Ser Arg Ile Asn Ala Pro Pro Ile Thr Thr Ser Pro
            1060                1065                1070        
 Ser Leu Asp Pro Ser Pro Ser Cys Gly Arg Thr Tyr Lys Pro Asn Gln
        1075                1080                1085            
 Ser Thr Asp Ala Lys Thr Ala Thr Arg Thr Pro Asp Gly Glu Thr Ala
    1090                1095                1100                
 Gln Ala Lys Glu Ala Gln Gln Lys Gln Gly Ser Pro His Gln Glu Trp
1105                1110                1115                1120
 Phe Thr Lys Tyr Phe Ser Phe
                1125        



      <210> 742
      <211> 1203
      <212> PRT
      <213> Homo sapiens


      <400> 742
 Met Asp Leu Arg Asp Phe Tyr Leu Leu Ala Ala Leu Ile Ala Cys Leu
   1               5                  10                  15    
 Arg Leu Asp Ser Ala Ile Ala Gln Glu Leu Ile Tyr Thr Ile Arg Glu
              20                  25                  30        
 Glu Leu Pro Glu Asn Val Pro Ile Gly Asn Ile Pro Lys Asp Leu Asn
          35                  40                  45            
 Ile Ser His Ile Asn Ala Ala Thr Gly Thr Ser Ala Ser Leu Val Tyr
      50                  55                  60                
 Arg Leu Val Ser Lys Ala Gly Asp Ala Pro Leu Val Lys Val Ser Ser
  65                  70                  75                  80
 Ser Thr Gly Glu Ile Phe Thr Thr Ser Asn Arg Ile Asp Arg Glu Lys
                  85                  90                  95    
 Leu Cys Ala Gly Ala Ser Tyr Ala Glu Glu Asn Glu Cys Phe Phe Glu
             100                 105                 110        
 Leu Glu Val Val Ile Leu Pro Asn Asp Phe Phe Arg Leu Ile Lys Ile
         115                 120                 125            
 Lys Ile Ile Val Lys Asp Thr Asn Asp Asn Ala Pro Met Phe Pro Ser
     130                 135                 140                
 Pro Val Ile Asn Ile Ser Ile Pro Glu Asn Thr Leu Ile Asn Ser Arg
 145                 150                 155                 160
 Phe Pro Ile Pro Ser Ala Thr Asp Pro Asp Thr Gly Phe Asn Gly Val
                 165                 170                 175    
 Gln His Tyr Glu Leu Leu Asn Gly Gln Ser Val Phe Gly Leu Asp Ile
             180                 185                 190        
 Val Glu Thr Pro Glu Gly Glu Lys Trp Pro Gln Leu Ile Val Gln Gln
         195                 200                 205            
 Asn Leu Asp Arg Glu Gln Lys Asp Thr Tyr Val Met Lys Ile Lys Val
     210                 215                 220                
 Glu Asp Gly Gly Thr Pro Gln Lys Ser Ser Thr Ala Ile Leu Gln Val
 225                 230                 235                 240
 Thr Val Ser Asp Val Asn Asp Asn Arg Pro Val Phe Lys Glu Gly Gln
                 245                 250                 255    
 Val Glu Val His Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Ile
             260                 265                 270        
 Gln Leu His Ala Thr Asp Ala Asp Ile Gly Ser Asn Ala Glu Ile Arg
         275                 280                 285            
 Tyr Ile Phe Gly Ala Gln Val Ala Pro Ala Thr Lys Arg Leu Phe Ala
     290                 295                 300                
 Leu Asn Asn Thr Thr Gly Leu Ile Thr Val Gln Arg Ser Leu Asp Arg
 305                 310                 315                 320
 Glu Glu Thr Ala Ile His Lys Val Thr Val Leu Ala Ser Asp Gly Ser
                 325                 330                 335    
 Ser Thr Pro Ala Arg Ala Thr Val Thr Ile Asn Val Thr Asp Val Asn
             340                 345                 350        
 Asp Asn Pro Pro Asn Ile Asp Leu Arg Tyr Ile Ile Ser Pro Ile Asn
         355                 360                 365            
 Gly Thr Val Tyr Leu Ser Glu Lys Asp Pro Val Asn Thr Lys Ile Ala
     370                 375                 380                
 Leu Ile Thr Val Ser Asp Lys Asp Thr Asp Val Asn Gly Lys Val Ile
 385                 390                 395                 400
 Cys Phe Ile Glu Arg Glu Val Pro Phe His Leu Lys Ala Val Tyr Asp
                 405                 410                 415    
 Asn Gln Tyr Leu Leu Glu Thr Ser Ser Leu Leu Asp Tyr Glu Gly Thr
             420                 425                 430        
 Lys Glu Phe Ser Phe Lys Ile Val Ala Ser Asp Ser Gly Lys Pro Ser
         435                 440                 445            
 Leu Asn Gln Thr Ala Leu Val Arg Val Lys Leu Glu Asp Glu Asn Asp
     450                 455                 460                
 Asn Pro Pro Ile Phe Asn Gln Pro Val Ile Glu Leu Ser Val Ser Glu
 465                 470                 475                 480
 Asn Asn Arg Arg Gly Leu Tyr Leu Thr Thr Ile Ser Ala Thr Asp Glu
                 485                 490                 495    
 Asp Ser Gly Lys Asn Ala Asp Ile Val Tyr Gln Leu Gly Pro Asn Ala
             500                 505                 510        
 Ser Phe Phe Asp Leu Asp Arg Lys Thr Gly Val Leu Thr Ala Ser Arg
         515                 520                 525            
 Val Phe Asp Arg Glu Glu Gln Glu Arg Phe Ile Phe Thr Val Thr Ala
     530                 535                 540                
 Arg Asp Asn Gly Thr Pro Pro Leu Gln Ser Gln Ala Ala Val Ile Val
 545                 550                 555                 560
 Thr Val Leu Asp Glu Asn Asp Asn Ser Pro Lys Phe Thr His Asn His
                 565                 570                 575    
 Phe Gln Phe Phe Val Ser Glu Asn Leu Pro Lys Tyr Ser Thr Val Gly
             580                 585                 590        
 Val Ile Thr Val Thr Asp Ala Asp Ala Gly Glu Asn Lys Ala Val Thr
         595                 600                 605            
 Leu Ser Ile Leu Asn Asp Asn Asp Asn Phe Val Leu Asp Pro Tyr Ser
     610                 615                 620                
 Gly Val Ile Lys Ser Asn Val Ser Phe Asp Arg Glu Gln Gln Ser Ser
 625                 630                 635                 640
 Tyr Thr Phe Asp Val Lys Ala Thr Asp Gly Gly Gln Pro Pro Arg Ser
                 645                 650                 655    
 Ser Thr Ala Lys Val Thr Ile Asn Val Met Asp Val Asn Asp Asn Ser
             660                 665                 670        
 Pro Val Val Ile Ser Pro Pro Ser Asn Thr Ser Phe Lys Leu Val Pro
         675                 680                 685            
 Leu Ser Ala Ile Pro Gly Ser Val Val Ala Glu Val Phe Ala Val Asp
     690                 695                 700                
 Val Asp Thr Gly Met Asn Ala Glu Leu Lys Tyr Thr Ile Val Ser Gly
 705                 710                 715                 720
 Asn Asn Lys Gly Leu Phe Arg Ile Asp Pro Val Thr Gly Asn Ile Thr
                 725                 730                 735    
 Leu Glu Glu Lys Pro Ala Pro Thr Asp Val Gly Leu His Arg Leu Val
             740                 745                 750        
 Val Asn Ile Ser Asp Leu Gly Tyr Pro Lys Ser Leu His Thr Leu Val
         755                 760                 765            
 Leu Val Phe Leu Tyr Val Asn Asp Thr Ala Gly Asn Ala Ser Tyr Ile
     770                 775                 780                
 Tyr Asp Leu Ile Arg Arg Thr Met Glu Thr Pro Leu Asp Arg Asn Ile
 785                 790                 795                 800
 Gly Asp Ser Ser Gln Pro Tyr Gln Asn Glu Asp Tyr Leu Thr Ile Met
                 805                 810                 815    
 Ile Ala Ile Ile Ala Gly Ala Met Val Val Ile Val Val Ile Phe Val
             820                 825                 830        
 Thr Val Leu Val Arg Cys Arg His Ala Ser Arg Phe Lys Ala Ala Gln
         835                 840                 845            
 Arg Ser Lys Gln Gly Ala Glu Trp Met Ser Pro Asn Gln Glu Asn Lys
     850                 855                 860                
 Gln Asn Lys Lys Lys Lys Arg Lys Lys Arg Lys Ser Pro Lys Ser Ser
 865                 870                 875                 880
 Leu Leu Asn Phe Val Thr Ile Glu Glu Ser Lys Pro Asp Asp Ala Val
                 885                 890                 895    
 His Glu Pro Ile Asn Gly Thr Ile Ser Leu Pro Ala Glu Leu Glu Glu
             900                 905                 910        
 Gln Ser Ile Gly Arg Phe Asp Trp Gly Pro Ala Pro Pro Thr Thr Phe
         915                 920                 925            
 Lys Pro Asn Ser Pro Asp Leu Ala Lys His Tyr Lys Ser Ala Ser Pro
     930                 935                 940                
 Gln Pro Ala Phe His Leu Lys Pro Asp Thr Pro Val Ser Val Lys Lys
 945                 950                 955                 960
 His His Val Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Gly Gly
                 965                 970                 975    
 Cys Asp Thr Leu Ser Lys Arg Ser Ser Thr Ser Ser Asp His Phe Ser
             980                 985                 990        
 Ala Ser Glu Cys Ser Ser Gln Gly Gly Phe Lys Thr Lys Gly Pro Leu
         995                1000                1005            
 His Thr Arg Gln Ser Gln Arg Arg Val Thr Phe His Leu Pro Asp Gly
    1010                1015                1020                
 Ser Gln Glu Ser Cys Ser Asp Ser Gly Leu Gly Asp His Glu Pro Val
1025                1030                1035                1040
 Gly Ser Gly Thr Leu Ile Ser His Pro Leu Pro Leu Val Gln Pro Gln
                1045                1050                1055    
 Asp Glu Phe Tyr Asp Gln Ala Ser Pro Asp Lys Arg Thr Glu Ala Asp
            1060                1065                1070        
 Gly Asn Ser Asp Pro Asn Ser Asp Gly Pro Leu Gly Pro Arg Gly Leu
        1075                1080                1085            
 Ala Glu Ala Thr Glu Met Cys Thr Gln Glu Cys Leu Val Leu Gly His
    1090                1095                1100                
 Ser Asp Asn Cys Trp Met Pro Pro Gly Leu Gly Pro Tyr Gln His Pro
1105                1110                1115                1120
 Lys Ser Pro Leu Ser Thr Phe Ala Pro Gln Lys Glu Trp Val Lys Lys
                1125                1130                1135    
 Asp Lys Leu Val Asn Gly His Thr Leu Thr Arg Ala Trp Lys Glu Asp
            1140                1145                1150        
 Ser Asn Arg Asn Gln Phe Asn Asp Arg Lys Gln Tyr Gly Ser Asn Glu
        1155                1160                1165            
 Gly His Phe Asn Asn Gly Ser His Met Thr Asp Ile Pro Leu Ala Asn
    1170                1175                1180                
 Leu Lys Ser Tyr Lys Gln Ala Gly Gly Ala Thr Glu Ser Pro Lys Glu
1185                1190                1195                1200
 His Gln Leu
            



      <210> 743
      <211> 452
      <212> PRT
      <213> Homo sapiens


      <400> 743
 Met Ile Thr Ala Ser His Asn Arg Lys Glu Asp Asn Gly Tyr Lys Val
   1               5                  10                  15    
 Tyr Trp Glu Thr Gly Ala Gln Ile Thr Ser Pro His Asp Lys Glu Ile
              20                  25                  30        
 Leu Lys Cys Ile Glu Glu Cys Val Glu Pro Trp Asn Gly Ser Trp Asn
          35                  40                  45            
 Asp Asn Leu Val Asp Thr Ser Pro Leu Lys Arg Asp Pro Leu Gln Asp
      50                  55                  60                
 Ile Cys Arg Arg Tyr Met Glu Asp Leu Lys Lys Ile Cys Phe Tyr Arg
  65                  70                  75                  80
 Glu Leu Asn Ser Lys Thr Thr Leu Lys Phe Val His Thr Ser Phe His
                  85                  90                  95    
 Gly Val Gly His Asp Tyr Val Gln Leu Ala Phe Lys Val Phe Gly Phe
             100                 105                 110        
 Lys Pro Pro Ile Pro Val Pro Glu Gln Lys Asp Pro Asp Pro Asp Phe
         115                 120                 125            
 Ser Thr Val Lys Cys Pro Asn Pro Glu Glu Gly Glu Ser Val Leu Glu
     130                 135                 140                
 Leu Ser Leu Arg Leu Ala Glu Lys Glu Asn Ala Arg Val Val Leu Ala
 145                 150                 155                 160
 Thr Asp Pro Asp Ala Asp Arg Leu Ala Ala Ala Glu Leu Gln Glu Asn
                 165                 170                 175    
 Gly Cys Trp Lys Val Phe Thr Gly Asn Glu Leu Ala Ala Leu Phe Gly
             180                 185                 190        
 Trp Trp Met Phe Asp Cys Trp Lys Lys Asn Lys Ser Arg Asn Ala Asp
         195                 200                 205            
 Val Lys Asn Val Tyr Met Leu Ala Thr Thr Val Ser Ser Lys Ile Leu
     210                 215                 220                
 Lys Ala Ile Ala Leu Lys Glu Gly Phe His Phe Glu Glu Thr Leu Pro
 225                 230                 235                 240
 Gly Phe Lys Trp Ile Gly Ser Arg Ile Ile Asp Leu Leu Glu Asn Gly
                 245                 250                 255    
 Lys Glu Val Leu Phe Ala Phe Glu Glu Ser Ile Gly Phe Leu Cys Gly
             260                 265                 270        
 Thr Ser Val Leu Asp Lys Asp Gly Val Ser Ala Ala Val Val Val Ala
         275                 280                 285            
 Glu Met Ala Ser Tyr Leu Glu Thr Met Asn Ile Thr Leu Lys Gln Gln
     290                 295                 300                
 Leu Val Lys Val Tyr Glu Lys Tyr Gly Tyr His Ile Ser Lys Thr Ser
 305                 310                 315                 320
 Tyr Phe Leu Cys Tyr Glu Pro Pro Thr Ile Lys Ser Ile Phe Glu Arg
                 325                 330                 335    
 Leu Arg Asn Phe Asp Ser Pro Lys Glu Tyr Pro Lys Phe Cys Gly Thr
             340                 345                 350        
 Phe Ala Ile Leu His Val Arg Asp Val Thr Thr Gly Tyr Asp Ser Ser
         355                 360                 365            
 Gln Pro Asn Lys Lys Ser Val Leu Pro Val Ser Lys Asn Ser Gln Met
     370                 375                 380                
 Ile Thr Phe Thr Phe Gln Asn Gly Cys Val Ala Thr Leu Arg Thr Ser
 385                 390                 395                 400
 Gly Thr Glu Pro Lys Ile Lys Tyr Tyr Ala Glu Met Cys Ala Ser Pro
                 405                 410                 415    
 Asp Gln Ser Asp Thr Ala Leu Leu Glu Glu Glu Leu Lys Lys Leu Ile
             420                 425                 430        
 Asp Ala Leu Ile Glu Asn Phe Leu Gln Pro Ser Lys Asn Gly Leu Ile
         435                 440                 445            
 Trp Arg Ser Val
     450        



      <210> 744
      <211> 783
      <212> PRT
      <213> Homo sapiens


      <400> 744
 Met Arg Trp Gln Cys Gly Thr Arg Phe Arg Gly Leu Arg Pro Ala Val
   1               5                  10                  15    
 Ala Pro Trp Thr Ala Leu Leu Ala Leu Gly Leu Pro Gly Trp Val Leu
              20                  25                  30        
 Ala Val Ser Ala Thr Ala Ala Ala Val Val Pro Glu Gln His Ala Ser
          35                  40                  45            
 Val Ala Gly Gln His Pro Leu Asp Trp Leu Leu Thr Asp Arg Gly Pro
      50                  55                  60                
 Phe His Arg Ala Gln Glu Tyr Ala Asp Phe Met Glu Arg Tyr Arg Gln
  65                  70                  75                  80
 Gly Phe Thr Thr Arg Tyr Arg Ile Tyr Arg Glu Phe Ala Arg Trp Lys
                  85                  90                  95    
 Val Asn Asn Leu Ala Leu Glu Arg Lys Asp Phe Phe Ser Leu Pro Leu
             100                 105                 110        
 Pro Leu Ala Pro Glu Phe Ile Arg Asn Ile Arg Leu Leu Gly Arg Arg
         115                 120                 125            
 Pro Asn Leu Gln Gln Val Thr Glu Asn Leu Ile Lys Lys Tyr Gly Thr
     130                 135                 140                
 His Phe Leu Leu Ser Ala Thr Leu Gly Gly Glu Glu Ser Leu Thr Ile
 145                 150                 155                 160
 Phe Val Asp Lys Gln Lys Leu Gly Arg Lys Thr Glu Thr Thr Gly Gly
                 165                 170                 175    
 Ala Ser Ile Ile Gly Gly Ser Gly Asn Ser Thr Ala Val Ser Leu Glu
             180                 185                 190        
 Thr Leu His Gln Leu Ala Ala Ser Tyr Phe Ile Asp Arg Glu Ser Thr
         195                 200                 205            
 Leu Arg Arg Leu His His Ile Gln Ile Ala Thr Gly Ala Ile Lys Val
     210                 215                 220                
 Thr Glu Thr Arg Thr Gly Pro Leu Gly Cys Ser Asn Tyr Asp Asn Leu
 225                 230                 235                 240
 Asp Ser Val Ser Ser Val Leu Val Gln Ser Pro Glu Asn Lys Val Gln
                 245                 250                 255    
 Leu Leu Gly Leu Gln Val Leu Leu Pro Glu Tyr Leu Arg Glu Arg Phe
             260                 265                 270        
 Val Ala Ala Ala Leu Ser Tyr Ile Thr Cys Ser Ser Glu Gly Glu Leu
         275                 280                 285            
 Val Cys Lys Glu Asn Asp Cys Trp Cys Lys Cys Ser Pro Thr Phe Pro
     290                 295                 300                
 Glu Cys Asn Cys Pro Asp Ala Asp Ile Gln Ala Met Glu Asp Ser Leu
 305                 310                 315                 320
 Leu Gln Ile Gln Asp Ser Trp Ala Thr His Asn Arg Gln Phe Glu Glu
                 325                 330                 335    
 Ser Glu Glu Phe Gln Ala Leu Leu Lys Arg Leu Pro Asp Asp Arg Phe
             340                 345                 350        
 Leu Asn Ser Thr Ala Ile Ser Gln Phe Trp Ala Met Asp Thr Ser Leu
         355                 360                 365            
 Gln His Arg Tyr Gln Gln Leu Gly Ala Gly Leu Lys Val Leu Phe Lys
     370                 375                 380                
 Lys Thr His Arg Ile Leu Arg Arg Leu Phe Asn Leu Cys Lys Arg Cys
 385                 390                 395                 400
 His Arg Gln Pro Arg Phe Arg Leu Pro Lys Glu Arg Ser Leu Ser Tyr
                 405                 410                 415    
 Trp Trp Asn Arg Ile Gln Ser Leu Leu Tyr Cys Gly Glu Ser Thr Phe
             420                 425                 430        
 Pro Gly Thr Phe Leu Glu Gln Ser His Ser Cys Thr Cys Pro Tyr Asp
         435                 440                 445            
 Gln Ser Ser Cys Gln Gly Pro Ile Pro Cys Ala Leu Gly Glu Gly Pro
     450                 455                 460                
 Ala Cys Ala His Cys Ala Pro Asp Asn Ser Thr Arg Cys Gly Ser Cys
 465                 470                 475                 480
 Asn Pro Gly Tyr Val Leu Ala Gln Gly Leu Cys Arg Pro Glu Val Ala
                 485                 490                 495    
 Glu Ser Leu Glu Asn Phe Leu Gly Leu Glu Thr Asp Leu Gln Asp Leu
             500                 505                 510        
 Glu Leu Lys Tyr Leu Leu Gln Lys Gln Asp Ser Arg Ile Glu Val His
         515                 520                 525            
 Ser Ile Phe Ile Ser Asn Asp Met Arg Leu Gly Ser Trp Phe Asp Pro
     530                 535                 540                
 Ser Trp Arg Lys Arg Met Leu Leu Thr Leu Lys Ser Asn Lys Tyr Lys
 545                 550                 555                 560
 Pro Gly Leu Val His Val Met Leu Ala Leu Ser Leu Gln Ile Cys Leu
                 565                 570                 575    
 Thr Lys Asn Ser Thr Leu Glu Pro Val Met Ala Ile Tyr Val Asn Pro
             580                 585                 590        
 Phe Gly Gly Ser His Ser Glu Ser Trp Phe Met Pro Val Asn Glu Gly
         595                 600                 605            
 Ser Phe Pro Asp Trp Glu Arg Thr Asn Val Asp Ala Ala Ala Gln Cys
     610                 615                 620                
 Gln Asn Trp Thr Ile Thr Leu Gly Asn Arg Trp Lys Thr Phe Phe Glu
 625                 630                 635                 640
 Thr Val His Val Tyr Leu Arg Ser Arg Ile Lys Ser Leu Asp Asp Ser
                 645                 650                 655    
 Ser Asn Glu Thr Ile Tyr Tyr Glu Pro Leu Glu Met Thr Asp Pro Ser
             660                 665                 670        
 Lys Asn Leu Gly Tyr Met Lys Ile Asn Thr Leu Gln Val Phe Gly Tyr
         675                 680                 685            
 Ser Leu Pro Phe Asp Pro Asp Ala Ile Arg Asp Leu Ile Leu Gln Leu
     690                 695                 700                
 Asp Tyr Pro Tyr Thr Gln Gly Ser Gln Asp Ser Ala Leu Leu Gln Leu
 705                 710                 715                 720
 Ile Glu Leu Arg Asp Arg Val Asn Gln Leu Ser Pro Pro Gly Lys Val
                 725                 730                 735    
 Arg Leu Asp Leu Phe Ser Cys Leu Leu Arg His Arg Leu Lys Leu Ala
             740                 745                 750        
 Asn Asn Glu Val Gly Arg Ile Gln Ser Ser Leu Arg Ala Phe Asn Ser
         755                 760                 765            
 Lys Leu Pro Asn Pro Val Glu Tyr Glu Thr Gly Lys Leu Cys Ser
     770                 775                 780            



      <210> 745
      <211> 591
      <212> PRT
      <213> Homo sapiens


      <400> 745
 Met Gln Phe Ser Asn Met Pro Ile Gly Tyr Arg Asp Ser Thr Pro Gln
   1               5                  10                  15    
 Gln Trp Ala Val Ser Met Arg Lys Asp Gly Lys Phe Tyr Cys Gln Leu
              20                  25                  30        
 Val Ile Cys Ser His Phe Ala Gln Asp Leu Trp Pro Glu Gln Gly Arg
          35                  40                  45            
 Glu Asp Ser Phe Gln Lys Val Ile Leu Arg Arg Tyr Glu Lys Cys Gly
      50                  55                  60                
 His Glu Asn Leu Gln Leu Lys Ile Gly Cys Thr Asn Val Asp Glu Cys
  65                  70                  75                  80
 Asn Leu His Lys Glu Cys Tyr Asp Glu Leu Asn Gln Cys Leu Thr Thr
                  85                  90                  95    
 Thr Gln Ser Glu Ile Phe Gln Tyr Asp Lys Tyr Val Asn Val Phe Tyr
             100                 105                 110        
 Lys Phe Ser Asn Pro Asn Ile Gln Lys Ile Arg His Thr Gly Lys Lys
         115                 120                 125            
 Pro Phe Lys Cys Lys Lys Cys Asp Lys Ser Phe Cys Met Leu Leu His
     130                 135                 140                
 Leu Thr Gln His Lys Arg Ile His Ile Arg Glu Asn Ser Tyr Gln Cys
 145                 150                 155                 160
 Glu Glu Cys Gly Lys Val Phe Asn Trp Phe Ser Thr Leu Thr Arg His
                 165                 170                 175    
 Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Gln Cys Gly
             180                 185                 190        
 Lys Ala Phe Lys Gln Ser Ser Thr Leu Thr Thr His Lys Ile Ile His
         195                 200                 205            
 Thr Gly Glu Lys Pro Tyr Arg Cys Glu Glu Cys Gly Lys Thr Phe Asn
     210                 215                 220                
 Arg Ser Ser His Leu Thr Thr His Lys Arg Ile His Thr Gly Glu Lys
 225                 230                 235                 240
 Pro Tyr Arg Cys Glu Glu Cys Gly Arg Ala Phe Asn Arg Ser Ser His
                 245                 250                 255    
 Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
             260                 265                 270        
 Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser Thr Leu Thr Thr His
         275                 280                 285            
 Lys Ile Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly
     290                 295                 300                
 Lys Ala Phe Tyr Arg Phe Ser Tyr Leu Thr Lys His Lys Ile Ile His
 305                 310                 315                 320
 Thr Gly Glu Lys Phe Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Asn
                 325                 330                 335    
 Trp Ser Ser Thr Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys
             340                 345                 350        
 Pro Tyr Lys Cys Glu Gln Cys Gly Lys Ala Phe Asn Glu Ser Ser Asn
         355                 360                 365            
 Leu Thr Ala His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
     370                 375                 380                
 Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser Pro Lys Leu Thr Ala His
 385                 390                 395                 400
 Lys Val Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly
                 405                 410                 415    
 Lys Ala Phe Asn Gln Phe Ser Asn Leu Thr Lys His Lys Ile Thr His
             420                 425                 430        
 Ile Gly Asp Thr Ser Tyr Lys Tyr Leu Glu Cys Asp Lys Ala Phe Ser
         435                 440                 445            
 Gln Ser Ser Thr Leu Thr Lys His Lys Val Ile His Thr Gly Glu Lys
     450                 455                 460                
 Pro Tyr Asn Cys Glu Glu Tyr Gly Lys Ala Phe Asn Gln Ser Ser Asn
 465                 470                 475                 480
 Leu Ile Glu Gln Lys Glu Pro Tyr Glu Cys Glu Glu Cys Gly Lys Ala
                 485                 490                 495    
 Phe Asn Gln Ser Ser Ile Leu Thr Thr His Arg Arg Ile His Thr Gly
             500                 505                 510        
 Glu Lys Phe Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Cys Ser
         515                 520                 525            
 Ser Asn Leu Thr Thr His Lys Lys Ile His Thr Gly Glu Arg Pro Tyr
     530                 535                 540                
 Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser Ile Leu Thr
 545                 550                 555                 560
 Thr His Glu Arg Ile Ile Leu Glu Arg Asn Ser Thr Asn Val Lys Asn
                 565                 570                 575    
 Val Ala Lys Pro Ser Ser Gly Pro His Thr Leu Leu His Ile Arg
             580                 585                 590    



      <210> 746
      <211> 570
      <212> PRT
      <213> Homo sapiens


      <400> 746
 Met Glu Asn Leu Lys Ser Gly Val Tyr Pro Leu Lys Glu Ala Ser Gly
   1               5                  10                  15    
 Cys Pro Gly Ala Asp Arg Asn Leu Leu Val Tyr Ser Phe Tyr Glu Lys
              20                  25                  30        
 Gly Pro Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu Glu
          35                  40                  45            
 Trp Gln Cys Leu Asp Thr Ala Gln Gln Asp Leu Tyr Arg Lys Val Met
      50                  55                  60                
 Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Ala Gly Ile Ala Val Ser
  65                  70                  75                  80
 Lys Pro Asp Leu Ile Thr Cys Leu Glu Gln Gly Lys Glu Pro Trp Asn
                  85                  90                  95    
 Met Lys Arg His Ala Met Val Asp Gln Pro Pro Val Thr Tyr Ser His
             100                 105                 110        
 Phe Ala Gln Asp Leu Trp Pro Glu Gln Gly Ile Lys Asp Ser Phe Gln
         115                 120                 125            
 Glu Val Ile Leu Arg Arg Tyr Gly Lys Cys Gly His Glu Asp Leu Gln
     130                 135                 140                
 Leu Arg Thr Gly Cys Arg Ser Val Asp Glu Cys Asn Leu His Lys Glu
 145                 150                 155                 160
 Cys Tyr Asp Glu Leu Asn Gln Cys Leu Thr Thr Thr Gln Ser Glu Ile
                 165                 170                 175    
 Phe Gln Tyr Asp Lys Tyr Val Asn Val Phe Tyr Lys Phe Ser Asn Pro
             180                 185                 190        
 Asn Ile Gln Lys Ile Arg His Thr Gly Lys Lys Pro Phe Lys Cys Lys
         195                 200                 205            
 Lys Cys Asp Lys Ser Phe Cys Met Leu Leu His Leu Thr Gln His Lys
     210                 215                 220                
 Arg Ile His Ile Arg Glu Asn Ser Tyr Gln Cys Glu Glu Cys Gly Lys
 225                 230                 235                 240
 Val Phe Asn Trp Phe Ser Thr Leu Thr Arg His Arg Arg Ile His Thr
                 245                 250                 255    
 Gly Glu Lys Pro Tyr Lys Cys Glu Gln Cys Gly Lys Ala Phe Lys Gln
             260                 265                 270        
 Ser Ser Thr Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro
         275                 280                 285            
 Tyr Arg Cys Glu Glu Cys Gly Lys Thr Phe Asn Arg Ser Ser His Leu
     290                 295                 300                
 Thr Thr His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Glu
 305                 310                 315                 320
 Glu Cys Gly Arg Ala Phe Asn Arg Ser Ser His Leu Thr Thr His Lys
                 325                 330                 335    
 Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
             340                 345                 350        
 Ala Phe Asn Gln Ser Ser Thr Leu Thr Thr His Lys Ile Ile His Ala
         355                 360                 365            
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Tyr Arg
     370                 375                 380                
 Phe Ser Tyr Leu Thr Lys His Lys Ile Ile His Thr Gly Glu Lys Phe
 385                 390                 395                 400
 Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Asn Trp Ser Ser Thr Leu
                 405                 410                 415    
 Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
             420                 425                 430        
 Gln Cys Gly Lys Ala Phe Asn Glu Ser Ser Asn Leu Thr Ala His Lys
         435                 440                 445            
 Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
     450                 455                 460                
 Ala Phe Asn Arg Ser Pro Lys Leu Thr Ala His Lys Val Ile His Ser
 465                 470                 475                 480
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln
                 485                 490                 495    
 Phe Ser Asn Leu Thr Lys His Lys Ile Thr His Ile Gly Asp Thr Ser
             500                 505                 510        
 Tyr Lys Tyr Leu Glu Cys Asp Lys Ala Phe Ser Gln Ser Ser Thr Leu
         515                 520                 525            
 Thr Lys His Lys Val Ile His Thr Gly Glu Lys Pro Tyr Asn Cys Glu
     530                 535                 540                
 Glu Tyr Gly Lys Ala Phe Asn Gln Ser Ser Asn Leu Ile Glu Gln Ser
 545                 550                 555                 560
 Asn Ser Tyr Trp Arg Glu Thr Leu Gln Met
                 565                 570



      <210> 747
      <211> 201
      <212> PRT
      <213> Homo sapiens


      <400> 747
 Met Val Thr Leu Ala Glu Leu Leu Val Leu Leu Ala Ala Leu Leu Ala
   1               5                  10                  15    
 Thr Val Ser Gly Tyr Phe Val Ser Ile Asp Ala His Ala Glu Glu Cys
              20                  25                  30        
 Phe Phe Glu Arg Val Thr Ser Gly Thr Lys Met Gly Leu Ile Phe Glu
          35                  40                  45            
 Val Ala Glu Gly Gly Phe Leu Asp Ile Asp Val Glu Ile Thr Gly Pro
      50                  55                  60                
 Asp Asn Lys Gly Ile Tyr Lys Gly Asp Arg Glu Ser Ser Gly Lys Tyr
  65                  70                  75                  80
 Thr Phe Ala Ala His Met Asp Gly Thr Tyr Lys Phe Cys Phe Ser Ile
                  85                  90                  95    
 Arg Met Ser Ala Met Thr Pro Lys Ile Val Met Phe Thr Ile Asp Ile
             100                 105                 110        
 Gly Glu Ala Pro Lys Gly Gln Asp Met Glu Thr Glu Ala His Gln Asn
         115                 120                 125            
 Lys Leu Glu Glu Met Ile Asn Glu Leu Ala Val Ala Met Thr Ala Val
     130                 135                 140                
 Lys His Glu Gln Glu Tyr Met Glu Val Arg Glu Arg Ile His Arg Ala
 145                 150                 155                 160
 Ile Asn Asp Asn Thr Asn Ser Arg Val Val Leu Trp Ser Phe Phe Glu
                 165                 170                 175    
 Ala Leu Val Leu Val Ala Met Thr Leu Gly Gln Ile Tyr Tyr Leu Lys
             180                 185                 190        
 Arg Phe Phe Glu Val Arg Arg Val Val
         195                 200    



      <210> 748
      <211> 406
      <212> PRT
      <213> Homo sapiens


      <400> 748
 Met Ala Gly Lys Arg Ser Gly Trp Ser Arg Ala Ala Leu Leu Gln Leu
   1               5                  10                  15    
 Leu Leu Gly Val Asn Leu Val Val Met Pro Pro Thr Arg Ala Arg Ser
              20                  25                  30        
 Leu Arg Phe Val Thr Leu Leu Tyr Arg His Gly Asp Arg Ser Pro Val
          35                  40                  45            
 Lys Thr Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Glu Trp Pro Gln Gly
      50                  55                  60                
 Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His Trp Glu Leu Gly
  65                  70                  75                  80
 Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn Thr Ser Tyr His
                  85                  90                  95    
 Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp Arg Thr Leu Met
             100                 105                 110        
 Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro Asn Gly Met Gln
         115                 120                 125            
 Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His Thr Val
     130                 135                 140                
 Pro Ile Thr Glu Asp Arg Leu Leu Lys Phe Pro Leu Gly Pro Cys Pro
 145                 150                 155                 160
 Arg Tyr Glu Gln Leu Gln Asn Glu Thr Arg Gln Thr Pro Glu Tyr Gln
                 165                 170                 175    
 Asn Glu Ser Ser Arg Asn Ala Gln Phe Leu Asp Met Val Ala Asn Glu
             180                 185                 190        
 Thr Gly Leu Thr Asp Leu Thr Leu Glu Thr Val Trp Asn Val Tyr Asp
         195                 200                 205            
 Thr Leu Phe Cys Glu Gln Thr His Gly Leu Arg Leu Pro Pro Trp Ala
     210                 215                 220                
 Ser Pro Gln Thr Met Gln Arg Leu Ser Arg Leu Lys Asp Phe Ser Phe
 225                 230                 235                 240
 Arg Phe Leu Phe Gly Ile Tyr Gln Gln Ala Glu Lys Ala Arg Leu Gln
                 245                 250                 255    
 Gly Gly Val Leu Leu Ala Gln Ile Arg Lys Asn Leu Thr Leu Met Ala
             260                 265                 270        
 Thr Thr Ser Gln Leu Pro Lys Leu Leu Val Tyr Ser Ala His Asp Thr
         275                 280                 285            
 Thr Leu Val Ala Leu Gln Met Ala Leu Asp Val Tyr Asn Gly Glu Gln
     290                 295                 300                
 Ala Pro Tyr Ala Ser Cys His Ile Phe Glu Leu Tyr Gln Glu Asp Ser
 305                 310                 315                 320
 Gly Asn Phe Ser Val Glu Met Tyr Phe Arg Asn Glu Ser Asp Lys Ala
                 325                 330                 335    
 Pro Trp Pro Leu Ser Leu Pro Gly Cys Pro His Arg Cys Pro Leu Gln
             340                 345                 350        
 Asp Phe Leu Arg Leu Thr Glu Pro Val Val Pro Lys Asp Trp Gln Gln
         355                 360                 365            
 Glu Cys Gln Leu Ala Ser Gly Pro Ala Asp Thr Val Leu Leu Leu Thr
     370                 375                 380                
 Val Leu Phe Arg Met Gln Ala Gln Pro Pro Gly Tyr Arg His Val Ala
 385                 390                 395                 400
 Asp Gly Glu Asp His Ala
                 405    



      <210> 749
      <211> 958
      <212> PRT
      <213> Homo sapiens


      <400> 749
 Met Pro Arg Gly Leu Glu Gln Lys Thr Leu Leu Pro Cys Ala Ala Ala
   1               5                  10                  15    
 Pro Gly Val Tyr Thr Cys Val Asn Tyr Met Phe Thr Asp Val Cys Thr
              20                  25                  30        
 Ser Val His Arg Leu Cys Leu Val Asp Ile Trp Gln Thr Thr Met Glu
          35                  40                  45            
 Ala Lys Lys Pro Leu Cys Ile Pro Lys Cys Ala Pro Ala Gln Pro His
      50                  55                  60                
 Cys Gln Ala Val Leu Val Gly Val Gly Ser Glu Glu Asp Gly Leu Pro
  65                  70                  75                  80
 Val Phe Pro Ala Asp His Ala Ala Cys Ser Cys Glu Val Gly Gly Ala
                  85                  90                  95    
 Gly Gly Val Ser Pro Gln Leu Val Trp Val Leu Leu Val Leu Pro Gly
             100                 105                 110        
 Pro Arg Ala Ala Ala Leu Leu Pro Pro Pro Cys Pro Thr Val His Gly
         115                 120                 125            
 Cys Gln Thr Trp Met Gly Cys Ser Ser Ala Val Gly Ala Thr Ile Asp
     130                 135                 140                
 Glu Val Glu Thr Asp Val Val Glu Ile Glu Ala Lys Leu Asp Lys Leu
 145                 150                 155                 160
 Val Lys Leu Cys Ser Gly Met Val Glu Ala Gly Lys Ala Tyr Val Ser
                 165                 170                 175    
 Thr Ser Arg Leu Phe Val Ser Gly Val Arg Asp Leu Ser Gln Gln Cys
             180                 185                 190        
 Gln Gly Asp Thr Val Ile Ser Glu Cys Leu Gln Arg Phe Ala Asp Ser
         195                 200                 205            
 Leu Gln Glu Val Val Asn Tyr His Met Ile Leu Phe Asp Gln Ala Gln
     210                 215                 220                
 Arg Ser Val Arg Gln Gln Leu Gln Ser Phe Val Lys Glu Asp Val Arg
 225                 230                 235                 240
 Lys Phe Lys Glu Thr Lys Lys Gln Phe Asp Lys Val Arg Glu Asp Leu
                 245                 250                 255    
 Glu Leu Ser Leu Val Arg Asn Ala Gln Ala Pro Arg His Arg Pro His
             260                 265                 270        
 Glu Val Glu Glu Ala Thr Gly Ala Leu Thr Leu Thr Arg Lys Cys Phe
         275                 280                 285            
 Arg His Leu Ala Leu Asp Tyr Val Leu Gln Ile Asn Val Leu Gln Ala
     290                 295                 300                
 Lys Lys Lys Phe Glu Ile Leu Asp Ser Met Leu Ser Phe Met His Ala
 305                 310                 315                 320
 Gln Ser Ser Phe Phe Gln Gln Gly Tyr Ser Leu Leu His Gln Leu Asp
                 325                 330                 335    
 Pro Tyr Met Lys Lys Leu Ala Ala Glu Leu Asp Gln Leu Val Ile Asp
             340                 345                 350        
 Ser Ala Val Glu Lys Arg Glu Met Glu Arg Lys His Ala Ala Ile Gln
         355                 360                 365            
 Gln Arg Thr Leu Leu Gln Asp Phe Ser Tyr Asp Glu Ser Lys Val Glu
     370                 375                 380                
 Phe Asp Val Asp Ala Pro Ser Gly Val Val Met Glu Gly Tyr Leu Phe
 385                 390                 395                 400
 Lys Arg Ala Ser Asn Ala Phe Lys Thr Trp Asn Arg Arg Trp Phe Ser
                 405                 410                 415    
 Ile Gln Asn Ser Gln Leu Val Tyr Gln Lys Lys Leu Lys Asp Ala Leu
             420                 425                 430        
 Thr Val Val Val Asp Asp Leu Arg Leu Cys Ser Val Lys Pro Cys Glu
         435                 440                 445            
 Asp Ile Glu Arg Arg Phe Cys Phe Glu Val Leu Ser Pro Thr Lys Ser
     450                 455                 460                
 Cys Met Leu Gln Ala Asp Ser Glu Lys Leu Arg Gln Ala Trp Val Gln
 465                 470                 475                 480
 Ala Val Gln Ala Ser Ile Ala Ser Ala Tyr Arg Glu Ser Pro Asp Ser
                 485                 490                 495    
 Cys Tyr Ser Glu Arg Leu Asp Arg Thr Ala Ser Pro Ser Thr Ser Ser
             500                 505                 510        
 Ile Asp Ser Ala Thr Asp Thr Arg Glu Arg Gly Val Lys Gly Glu Ser
         515                 520                 525            
 Val Leu Gln Arg Val Gln Ser Val Ala Gly Asn Ser Gln Cys Gly Asp
     530                 535                 540                
 Cys Gly Gln Pro Asp Pro Arg Trp Ala Ser Ile Asn Leu Gly Val Leu
 545                 550                 555                 560
 Leu Cys Ile Glu Cys Ser Gly Ile His Arg Ser Leu Gly Val His Cys
                 565                 570                 575    
 Ser Lys Val Arg Ser Leu Thr Leu Asp Ser Trp Glu Pro Glu Leu Leu
             580                 585                 590        
 Lys Leu Met Cys Glu Leu Gly Asn Ser Ala Val Asn Gln Ile Tyr Glu
         595                 600                 605            
 Ala Gln Cys Glu Gly Ala Gly Ser Arg Lys Pro Thr Ala Ser Ser Ser
     610                 615                 620                
 Arg Gln Asp Lys Glu Ala Trp Ile Lys Asp Lys Tyr Val Glu Lys Lys
 625                 630                 635                 640
 Phe Leu Arg Lys Ala Pro Met Ala Pro Ala Leu Glu Ala Pro Arg Arg
                 645                 650                 655    
 Trp Arg Val Gln Lys Cys Leu Arg Pro His Ser Ser Pro Arg Ala Pro
             660                 665                 670        
 Thr Ala Arg Arg Lys Val Arg Leu Glu Pro Val Leu Pro Cys Val Ala
         675                 680                 685            
 Ala Leu Ser Ser Val Gly Thr Leu Asp Arg Lys Phe Arg Arg Asp Ser
     690                 695                 700                
 Leu Phe Cys Pro Asp Glu Leu Asp Ser Leu Phe Ser Tyr Phe Asp Ala
 705                 710                 715                 720
 Gly Ala Ala Gly Ala Gly Pro Arg Ser Leu Ser Ser Asp Ser Gly Leu
                 725                 730                 735    
 Gly Gly Ser Ser Asp Gly Ser Ser Asp Val Leu Ala Phe Gly Ser Gly
             740                 745                 750        
 Ser Val Val Asp Ser Val Thr Glu Glu Glu Gly Ala Glu Ser Glu Glu
         755                 760                 765            
 Ser Ser Gly Glu Ala Asp Gly Asp Thr Glu Ala Glu Ala Trp Gly Leu
     770                 775                 780                
 Ala Asp Val Arg Glu Leu His Pro Gly Leu Leu Ala His Arg Ala Ala
 785                 790                 795                 800
 Arg Ala Arg Asp Leu Pro Ala Leu Ala Ala Ala Leu Ala His Gly Ala
                 805                 810                 815    
 Glu Val Asn Trp Ala Asp Ala Glu Asp Glu Gly Lys Thr Pro Leu Val
             820                 825                 830        
 Gln Ala Val Leu Gly Gly Ser Leu Ile Val Cys Glu Phe Leu Leu Gln
         835                 840                 845            
 Asn Gly Ala Asp Val Asn Gln Arg Asp Ser Arg Gly Arg Ala Pro Leu
     850                 855                 860                
 His His Ala Thr Leu Leu Gly Arg Thr Gly Gln Val Cys Leu Phe Leu
 865                 870                 875                 880
 Lys Arg Gly Ala Asp Gln His Ala Leu Asp Gln Glu Gln Arg Asp Pro
                 885                 890                 895    
 Leu Ala Ile Ala Val Gln Ala Ala Asn Ala Asp Ile Val Thr Leu Leu
             900                 905                 910        
 Arg Leu Ala Arg Met Ala Glu Glu Met Arg Glu Ala Glu Ala Ala Pro
         915                 920                 925            
 Gly Pro Pro Gly Ala Leu Ala Gly Ser Pro Thr Glu Leu Gln Phe Arg
     930                 935                 940                
 Arg Cys Ile Gln Glu Phe Ile Ser Leu His Leu Glu Glu Ser
 945                 950                 955            



      <210> 750
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 750
 Met Glu Pro Glu Glu Gly Thr Pro Leu Trp Arg Leu Gln Lys Leu Pro
   1               5                  10                  15    
 Ala Glu Leu Gly Pro Gln Leu Leu His Lys Ile Ile Asp Gly Ile Cys
              20                  25                  30        
 Gly Arg Ala Tyr Pro Val Tyr Gln Asp Tyr His Thr Val Trp Glu Ser
          35                  40                  45            
 Glu Glu Trp Met His Val Leu Glu Asp Ile Ala Lys Phe Phe Lys Ala
      50                  55                  60                
 Ile Val Gly Lys Asn Leu Pro Asp Glu Glu Ile Phe Gln Gln Leu Asn
  65                  70                  75                  80
 Gln Leu Asn Ser Leu His Gln Glu Thr Ile Met Lys Cys Val Lys Ser
                  85                  90                  95    
 Arg Lys Asp Glu Ile Lys Gln Ala Leu Ser Arg Glu Ile Val Ala Ile
             100                 105                 110        
 Ser Ser Ala Gln Leu Gln Asp Phe Asp Trp Gln Val Lys Leu Ala Leu
         115                 120                 125            
 Ser Ser Asp Lys Ile Ala Ala Leu Arg Met Pro Leu Leu Ser Leu His
     130                 135                 140                
 Leu Asp Val Lys Glu Asn Gly Glu Val Lys Pro Tyr Ser Ile Glu Met
 145                 150                 155                 160
 Ser Arg Glu Glu Leu Gln Asn Leu Ile Gln Ser Leu Glu Ala Ala Asn
                 165                 170                 175    
 Lys Val Val Leu Gln Leu Lys
             180            



      <210> 751
      <211> 813
      <212> PRT
      <213> Homo sapiens


      <400> 751
 Met Arg Gly Ala Gly Ile Gly Gly Arg Lys Ala Val Gly Ala Asn Gln
   1               5                  10                  15    
 Ala Ala Ser Arg Pro Arg His Val Ala Trp Ala Ala Arg Ser Asp Cys
              20                  25                  30        
 Ala Ser Ala Arg Ala Pro Pro Gly Leu Ala Arg Gly Cys Leu Gly Arg
          35                  40                  45            
 Arg Gly Pro Gln Val Gln Gln Leu Asp Met Glu Asn Gln Arg Ser Ser
      50                  55                  60                
 Pro Leu Ser Phe Pro Ser Val Pro Gln Glu Glu Thr Leu Arg Gln Ala
  65                  70                  75                  80
 Pro Ala Gly Leu Pro Arg Glu Thr Leu Phe Gln Ser Arg Val Leu Pro
                  85                  90                  95    
 Pro Lys Glu Ile Pro Ser Leu Ser Pro Thr Ile Pro Arg Gln Gly Ser
             100                 105                 110        
 Leu Pro Gln Thr Ser Ser Ala Pro Lys Gln Glu Thr Ser Gly Arg Met
         115                 120                 125            
 Pro His Val Leu Gln Lys Gly Pro Ser Leu Leu Cys Ser Ala Ala Ser
     130                 135                 140                
 Glu Gln Glu Thr Ser Leu Gln Gly Pro Leu Ala Ser Gln Glu Gly Thr
 145                 150                 155                 160
 Gln Tyr Pro Pro Pro Ala Ala Ala Glu Gln Glu Val Ser Leu Leu Ser
                 165                 170                 175    
 His Ser Pro His His Gln Glu Ala Pro Val His Ser Pro Glu Ala Pro
             180                 185                 190        
 Glu Lys Asp Pro Leu Thr Leu Ser Pro Thr Val Pro Glu Thr Asp Met
         195                 200                 205            
 Asp Pro Leu Leu Gln Ser Pro Val Ser Gln Lys Asp Thr Pro Phe Gln
     210                 215                 220                
 Ile Ser Ser Ala Val Gln Lys Glu Gln Pro Leu Pro Thr Ala Glu Ile
 225                 230                 235                 240
 Thr Arg Leu Ala Val Trp Ala Ala Val Gln Ala Val Glu Arg Lys Leu
                 245                 250                 255    
 Glu Ala Gln Ala Met Arg Leu Leu Thr Leu Glu Gly Arg Thr Gly Thr
             260                 265                 270        
 Asn Glu Lys Lys Ile Ala Asp Cys Glu Lys Thr Ala Val Glu Phe Ala
         275                 280                 285            
 Asn His Leu Glu Ser Lys Trp Val Val Leu Gly Thr Leu Leu Gln Glu
     290                 295                 300                
 Tyr Gly Leu Leu Gln Arg Arg Leu Glu Asn Met Glu Asn Leu Leu Lys
 305                 310                 315                 320
 Asn Arg Asn Phe Trp Ile Leu Arg Leu Pro Pro Gly Ser Asn Gly Glu
                 325                 330                 335    
 Val Pro Lys Val Pro Val Thr Phe Asp Asp Val Ala Val His Phe Ser
             340                 345                 350        
 Glu Gln Glu Trp Gly Asn Leu Ser Glu Trp Gln Lys Glu Leu Tyr Lys
         355                 360                 365            
 Asn Val Met Arg Gly Asn Tyr Glu Ser Leu Val Ser Met Asp Tyr Ala
     370                 375                 380                
 Ile Ser Lys Pro Asp Leu Met Ser Gln Met Glu Arg Gly Glu Arg Pro
 385                 390                 395                 400
 Thr Met Gln Glu Gln Glu Asp Ser Glu Glu Gly Glu Thr Pro Thr Asp
                 405                 410                 415    
 Pro Ser Ala Ala His Asp Gly Ile Val Ile Lys Ile Glu Val Gln Thr
             420                 425                 430        
 Asn Asp Glu Gly Ser Glu Ser Leu Glu Thr Pro Glu Pro Leu Met Gly
         435                 440                 445            
 Gln Val Glu Glu His Gly Phe Gln Asp Ser Glu Leu Gly Asp Pro Cys
     450                 455                 460                
 Gly Glu Gln Pro Asp Leu Asp Met Gln Glu Pro Glu Asn Thr Leu Glu
 465                 470                 475                 480
 Glu Ser Thr Glu Gly Ser Ser Glu Phe Ser Glu Leu Lys Gln Met Leu
                 485                 490                 495    
 Val Gln Gln Arg Asn Cys Thr Glu Gly Ile Val Ile Lys Thr Glu Glu
             500                 505                 510        
 Gln Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Leu Pro Gln His
         515                 520                 525            
 Leu Gln Ser Leu Gly Gln Leu Ser Gly Arg Tyr Glu Ala Ser Met Tyr
     530                 535                 540                
 Gln Thr Pro Leu Pro Gly Glu Met Ser Pro Glu Gly Glu Glu Ser Pro
 545                 550                 555                 560
 Pro Pro Leu Gln Leu Gly Asn Pro Ala Val Lys Arg Leu Ala Pro Ser
                 565                 570                 575    
 Val His Gly Glu Arg His Leu Ser Glu Asn Arg Gly Ala Ser Ser Gln
             580                 585                 590        
 Gln Gln Arg Asn Arg Arg Gly Glu Arg Pro Phe Thr Cys Met Glu Cys
         595                 600                 605            
 Gly Lys Ser Phe Arg Leu Lys Ile Asn Leu Ile Ile His Gln Arg Asn
     610                 615                 620                
 His Ile Lys Glu Gly Pro Tyr Glu Cys Ala Glu Cys Glu Ile Ser Phe
 625                 630                 635                 640
 Arg His Lys Gln Gln Leu Thr Leu His Gln Arg Ile His Arg Val Arg
                 645                 650                 655    
 Gly Gly Cys Val Ser Pro Glu Arg Gly Pro Thr Phe Asn Pro Lys His
             660                 665                 670        
 Ala Leu Lys Pro Arg Pro Lys Ser Pro Ser Ser Gly Ser Gly Gly Gly
         675                 680                 685            
 Gly Pro Lys Pro Tyr Lys Cys Pro Glu Cys Asp Ser Ser Phe Ser His
     690                 695                 700                
 Lys Ser Ser Leu Thr Lys His Gln Ile Thr His Thr Gly Glu Arg Pro
 705                 710                 715                 720
 Tyr Thr Cys Pro Glu Cys Lys Lys Ser Phe Arg Leu His Ile Ser Leu
                 725                 730                 735    
 Val Ile His Gln Arg Val His Ala Gly Lys His Glu Val Ser Phe Ile
             740                 745                 750        
 Cys Ser Leu Cys Gly Lys Ser Phe Ser Arg Pro Ser His Leu Leu Arg
         755                 760                 765            
 His Gln Arg Thr His Thr Gly Glu Arg Pro Phe Lys Cys Pro Glu Cys
     770                 775                 780                
 Glu Lys Ser Phe Ser Glu Lys Ser Lys Leu Thr Asn His Cys Arg Val
 785                 790                 795                 800
 His Ser Arg Ala Ala Ala Arg Gln Ala Leu Ser Pro Ser
                 805                 810            



      <210> 752
      <211> 762
      <212> PRT
      <213> Homo sapiens


      <400> 752
 Met Asp Cys Tyr Thr Ala Asn Trp Asn Pro Leu Gly Asp Ser Ala Phe
   1               5                  10                  15    
 Tyr Arg Lys Tyr Glu Leu Tyr Ser Met Asp Trp Asp Leu Lys Glu Glu
              20                  25                  30        
 Leu Arg Asp Cys Leu Val Ala Ala Ala Pro Tyr Gly Gly Pro Ile Ala
          35                  40                  45            
 Leu Leu Arg Asn Pro Trp Arg Lys Glu Lys Ala Ala Ser Val Arg Pro
      50                  55                  60                
 Val Leu Asp Ile Tyr Ser Ala Ser Gly Met Pro Leu Ala Ser Leu Leu
  65                  70                  75                  80
 Trp Lys Ser Gly Pro Val Val Ser Leu Gly Trp Ser Ala Glu Glu Glu
                  85                  90                  95    
 Leu Leu Cys Val Gln Glu Asp Gly Ala Val Leu Val Tyr Gly Leu His
             100                 105                 110        
 Gly Asp Phe Arg Arg His Phe Ser Met Gly Asn Glu Val Leu Gln Asn
         115                 120                 125            
 Arg Val Leu Asp Ala Arg Ile Phe His Thr Glu Phe Gly Ser Gly Val
     130                 135                 140                
 Ala Ile Leu Thr Gly Ala His Arg Phe Thr Leu Ser Ala Asn Val Gly
 145                 150                 155                 160
 Asp Leu Lys Leu Arg Arg Met Pro Glu Val Pro Gly Leu Gln Ser Ala
                 165                 170                 175    
 Pro Ser Cys Trp Thr Val Leu Cys Gln Asp Arg Val Ala His Ile Leu
             180                 185                 190        
 Leu Ala Val Gly Pro Asp Leu Tyr Leu Leu Asp His Ala Ala Cys Ser
         195                 200                 205            
 Ala Val Thr Pro Pro Gly Leu Ala Pro Gly Val Ser Ser Phe Leu Gln
     210                 215                 220                
 Met Ala Val Ser Phe Thr Tyr Arg His Leu Ala Leu Phe Thr Asp Thr
 225                 230                 235                 240
 Gly Tyr Ile Trp Met Gly Thr Ala Ser Leu Lys Glu Lys Leu Cys Glu
                 245                 250                 255    
 Phe Asn Cys Asn Ile Arg Ala Pro Pro Lys Gln Met Val Trp Cys Ser
             260                 265                 270        
 Arg Pro Arg Ser Lys Glu Arg Ala Val Val Val Ala Trp Glu Arg Arg
         275                 280                 285            
 Leu Met Val Val Gly Asp Ala Pro Glu Ser Ile Gln Phe Val Leu Asp
     290                 295                 300                
 Glu Asp Ser Tyr Leu Val Pro Glu Leu Asp Gly Val Arg Ile Phe Ser
 305                 310                 315                 320
 Arg Ser Thr His Glu Phe Leu His Glu Val Pro Ala Ala Ser Glu Glu
                 325                 330                 335    
 Ile Phe Lys Ile Ala Ser Met Ala Pro Gly Ala Leu Leu Leu Glu Ala
             340                 345                 350        
 Gln Lys Glu Tyr Glu Lys Glu Ser Gln Lys Ala Asp Glu Tyr Leu Arg
         355                 360                 365            
 Glu Ile Gln Glu Leu Gly Gln Leu Thr Gln Ala Val Gln Gln Cys Ile
     370                 375                 380                
 Glu Ala Ala Gly His Glu His Gln Pro Asp Met Gln Lys Ser Leu Leu
 385                 390                 395                 400
 Arg Ala Ala Ser Phe Gly Lys Cys Phe Leu Asp Arg Phe Pro Pro Asp
                 405                 410                 415    
 Ser Phe Val His Met Cys Gln Asp Leu Arg Val Leu Asn Ala Val Arg
             420                 425                 430        
 Asp Tyr His Ile Gly Ile Pro Leu Thr Tyr Ser Gln Tyr Lys Gln Leu
         435                 440                 445            
 Thr Ile Gln Val Leu Leu Asp Arg Leu Val Leu Arg Arg Leu Tyr Pro
     450                 455                 460                
 Leu Ala Ile Gln Ile Cys Glu Tyr Leu Arg Leu Pro Glu Val Gln Gly
 465                 470                 475                 480
 Val Ser Arg Ile Leu Ala His Trp Ala Cys Tyr Lys Val Gln Gln Lys
                 485                 490                 495    
 Asp Val Ser Asp Glu Asp Val Ala Arg Ala Ile Asn Gln Lys Leu Gly
             500                 505                 510        
 Asp Thr Pro Gly Val Ser Tyr Ser Asp Ile Ala Ala Arg Ala Tyr Gly
         515                 520                 525            
 Cys Gly Arg Thr Glu Leu Ala Ile Lys Leu Leu Glu Tyr Glu Pro Arg
     530                 535                 540                
 Ser Gly Glu Gln Gly Asp Thr Pro Asp Val Ala Tyr Ser Asp Ile Ala
 545                 550                 555                 560
 Ala Arg Ala Tyr Gly Cys Gly Arg Thr Glu Leu Ala Ile Lys Leu Leu
                 565                 570                 575    
 Glu Tyr Glu Pro Arg Ser Gly Glu Gln Val Pro Leu Leu Leu Lys Met
             580                 585                 590        
 Lys Arg Ser Lys Leu Ala Leu Ser Lys Ala Ile Glu Ser Gly Asp Thr
         595                 600                 605            
 Asp Leu Val Phe Thr Val Leu Leu His Leu Lys Asn Glu Leu Asn Arg
     610                 615                 620                
 Gly Asp Phe Phe Met Thr Leu Arg Asn Gln Pro Met Ala Leu Ser Leu
 625                 630                 635                 640
 Tyr Arg Gln Phe Cys Lys His Gln Glu Leu Glu Thr Leu Lys Asp Leu
                 645                 650                 655    
 Tyr Asn Gln Asp Asp Asn His Gln Glu Leu Gly Ser Phe His Ile Arg
             660                 665                 670        
 Ala Ser Tyr Ala Ala Glu Glu Arg Ile Glu Gly Arg Val Ala Ala Leu
         675                 680                 685            
 Gln Thr Ala Ala Asp Ala Phe Tyr Lys Ala Lys Asn Glu Phe Ala Ala
     690                 695                 700                
 Lys Ala Thr Glu Asp Gln Met Arg Leu Leu Arg Leu Gln Arg Arg Leu
 705                 710                 715                 720
 Glu Asp Glu Leu Gly Gly Gln Phe Leu Asp Leu Ser Leu His Asp Thr
                 725                 730                 735    
 Val Thr Thr Leu Ile Leu Gly Gly His Asn Lys Arg Ala Glu Gln Leu
             740                 745                 750        
 Ala Arg Asp Phe Arg Ile Pro Asp Lys Arg
         755                 760        



      <210> 753
      <211> 420
      <212> PRT
      <213> Homo sapiens


      <400> 753
 Met Leu Pro Gly Leu Arg Arg Leu Leu Gln Ala Pro Ala Ser Ala Cys
   1               5                  10                  15    
 Leu Leu Leu Met Leu Leu Ala Leu Pro Leu Ala Ala Pro Ser Cys Pro
              20                  25                  30        
 Met Leu Cys Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys Gln Ala
          35                  40                  45            
 Asn Asn Phe Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr Gln Arg
      50                  55                  60                
 Leu Phe Leu Gln Asn Asn Leu Ile Arg Thr Leu Arg Pro Gly Thr Phe
  65                  70                  75                  80
 Gly Ser Asn Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu Ser Thr
                  85                  90                  95    
 Ile Tyr Pro Gly Thr Phe Arg His Leu Gln Ala Leu Glu Glu Leu Asp
             100                 105                 110        
 Leu Gly Asp Asn Arg His Leu Arg Ser Leu Glu Pro Asp Thr Phe Gln
         115                 120                 125            
 Gly Leu Glu Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln Leu Ser
     130                 135                 140                
 Ser Leu Pro Gly Asn Ile Phe Arg Gly Leu Val Ser Leu Gln Tyr Leu
 145                 150                 155                 160
 Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln Asp Asp Leu Phe Ala
                 165                 170                 175    
 Asp Leu Ala Asn Leu Ser His Leu Phe Leu His Gly Asn Arg Leu Arg
             180                 185                 190        
 Leu Leu Thr Glu His Val Phe Arg Gly Leu Gly Ser Leu Asp Arg Leu
         195                 200                 205            
 Leu Leu His Gly Asn Arg Leu Gln Gly Val His Arg Ala Ala Phe Arg
     210                 215                 220                
 Gly Leu Ser Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser Leu Ala
 225                 230                 235                 240
 Ser Leu Pro Gly Glu Ala Leu Ala Asp Leu Pro Ser Leu Glu Phe Leu
                 245                 250                 255    
 Arg Leu Asn Ala Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg Pro Leu
             260                 265                 270        
 Trp Ala Trp Phe Gln Arg Ala Arg Val Ser Ser Ser Asp Val Thr Cys
         275                 280                 285            
 Ala Thr Pro Pro Glu Arg Gln Gly Arg Asp Leu Arg Ala Leu Arg Glu
     290                 295                 300                
 Ala Asp Phe Gln Ala Cys Pro Pro Ala Ala Pro Thr Arg Pro Gly Ser
 305                 310                 315                 320
 Arg Ala Arg Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val Ala Glu
                 325                 330                 335    
 Ala Gly Ala Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp Leu Pro
             340                 345                 350        
 Ala Glu Asp Ser Arg Gly Arg Gln Gly Gly Asp Ala Pro Thr Glu Asp
         355                 360                 365            
 Asp Tyr Trp Gly Gly Tyr Gly Gly Glu Asp Gln Arg Gly Glu Gln Met
     370                 375                 380                
 Cys Pro Gly Ala Ala Cys Gln Ala Pro Pro Asp Ser Arg Gly Pro Ala
 385                 390                 395                 400
 Leu Ser Ala Gly Leu Pro Ser Pro Leu Leu Cys Leu Leu Leu Leu Val
                 405                 410                 415    
 Pro His His Leu
             420



      <210> 754
      <211> 1508
      <212> PRT
      <213> Homo sapiens


      <400> 754
 Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile
   1               5                  10                  15    
 Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn
              20                  25                  30        
 Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser
          35                  40                  45            
 Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys
      50                  55                  60                
 Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser
  65                  70                  75                  80
 Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile
                  85                  90                  95    
 Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys
             100                 105                 110        
 Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys
         115                 120                 125            
 Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met
     130                 135                 140                
 Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu
 145                 150                 155                 160
 Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro
                 165                 170                 175    
 Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met
             180                 185                 190        
 Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr
         195                 200                 205            
 Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val
     210                 215                 220                
 Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile
 225                 230                 235                 240
 Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val
                 245                 250                 255    
 Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg
             260                 265                 270        
 Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys
         275                 280                 285            
 Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile
     290                 295                 300                
 Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu
 305                 310                 315                 320
 Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser
                 325                 330                 335    
 Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His
             340                 345                 350        
 Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp
         355                 360                 365            
 Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn
     370                 375                 380                
 Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro
 385                 390                 395                 400
 Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu
                 405                 410                 415    
 Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro
             420                 425                 430        
 Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr
         435                 440                 445            
 Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys
     450                 455                 460                
 Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp
 465                 470                 475                 480
 Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys
                 485                 490                 495    
 Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys
             500                 505                 510        
 Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu
         515                 520                 525            
 Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly
     530                 535                 540                
 Val Val Ala Asp Lys Ile Gln Phe Ser Val Gly Met Cys Phe Asp Asn
 545                 550                 555                 560
 Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu
                 565                 570                 575    
 Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg
             580                 585                 590        
 Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser
         595                 600                 605            
 Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro
     610                 615                 620                
 Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp
 625                 630                 635                 640
 Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln
                 645                 650                 655    
 Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe
             660                 665                 670        
 Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile
         675                 680                 685            
 Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala
     690                 695                 700                
 Met Gly Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro Leu
 705                 710                 715                 720
 His Gln Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr Trp
                 725                 730                 735    
 Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val His
             740                 745                 750        
 Val Thr Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe Cys
         755                 760                 765            
 Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu Thr
     770                 775                 780                
 Ala Phe Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val Val
 785                 790                 795                 800
 Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu Lys
                 805                 810                 815    
 Asp Cys Ile Arg Val Gln Thr Asp Leu Ala Lys Ser His Glu Tyr Gln
             820                 825                 830        
 Leu Glu Ser Trp Ala Asp Ser Gln Thr Ser Ser Cys Leu Cys Ala Asp
         835                 840                 845            
 Asp Ala Lys Thr His His Trp Asn Ile Thr Ala Val Lys Leu Gly His
     850                 855                 860                
 Ile Asn Phe Thr Ile Ser Thr Lys Ile Leu Asp Ser Asn Glu Pro Cys
 865                 870                 875                 880
 Gly Gly Gln Lys Gly Phe Val Pro Gln Lys Gly Arg Ser Asp Thr Leu
                 885                 890                 895    
 Ile Lys Pro Val Leu Val Lys Pro Glu Gly Val Leu Val Glu Lys Thr
             900                 905                 910        
 His Ser Ser Leu Leu Cys Pro Lys Gly Lys Val Ala Ser Glu Ser Val
         915                 920                 925            
 Ser Leu Glu Leu Pro Val Asp Ile Val Pro Asp Ser Thr Lys Ala Tyr
     930                 935                 940                
 Val Thr Val Leu Gly Lys Gln Leu Glu Ile Leu Asp Ser Glu Arg Lys
 945                 950                 955                 960
 Arg Arg Met Glu Ala Ala Lys Val Trp Arg Asp Ile Met Gly Thr Ala
                 965                 970                 975    
 Leu Gln Asn Leu Asp Gly Leu Val Gln Met Pro Ser Gly Cys Gly Glu
             980                 985                 990        
 Gln Asn Met Val Leu Phe Ala Pro Ile Ile Tyr Val Leu Gln Tyr Leu
         995                1000                1005            
 Glu Lys Ala Gly Leu Leu Thr Glu Glu Ile Arg Ser Arg Ala Val Gly
    1010                1015                1020                
 Phe Leu Glu Ile Gly Tyr Gln Lys Glu Leu Met Tyr Lys His Ser Asn
1025                1030                1035                1040
 Gly Ser Tyr Ser Ala Phe Gly Glu Arg Asp Gly Asn Gly Asn Thr Trp
                1045                1050                1055    
 Leu Thr Ala Phe Val Thr Lys Cys Phe Gly Gln Ala Gln Lys Phe Ile
            1060                1065                1070        
 Phe Ile Asp Pro Lys Asn Ile Gln Asp Ala Leu Lys Trp Met Ala Gly
        1075                1080                1085            
 Asn Gln Leu Pro Ser Gly Cys Tyr Ala Asn Val Gly Asn Leu Leu His
    1090                1095                1100                
 Thr Ala Met Lys Gly Gly Val Asp Asp Glu Val Ser Leu Thr Ala Tyr
1105                1110                1115                1120
 Val Thr Ala Ala Leu Leu Glu Met Gly Lys Asp Val Asp Asp Pro Met
                1125                1130                1135    
 Val Ser Gln Gly Leu Arg Cys Leu Lys Asn Ser Ala Thr Ser Thr Thr
            1140                1145                1150        
 Asn Leu Tyr Thr Gln Ala Leu Leu Ala Tyr Ile Phe Ser Leu Ala Gly
        1155                1160                1165            
 Glu Met Asp Ile Arg Asn Ile Leu Leu Lys Gln Leu Asp Gln Gln Ala
    1170                1175                1180                
 Ile Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser
1185                1190                1195                1200
 Ser Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu
                1205                1210                1215    
 Thr Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln
            1220                1225                1230        
 Lys Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln
        1235                1240                1245            
 His Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala
    1250                1255                1260                
 Leu Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Met Pro Ser Glu
1265                1270                1275                1280
 Glu Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe
                1285                1290                1295    
 Asn Ile Gln Ser Val Asn Arg Leu Val Phe Gln Gln Asp Thr Leu Pro
            1300                1305                1310        
 Asn Val Pro Gly Met Tyr Thr Leu Glu Ala Ser Gly Gln Gly Cys Val
        1315                1320                1325            
 Tyr Val Gln Thr Val Leu Arg Tyr Asn Ile Leu Pro Pro Thr Asn Met
    1330                1335                1340                
 Lys Thr Phe Ser Leu Ser Val Glu Ile Gly Lys Ala Arg Cys Glu Gln
1345                1350                1355                1360
 Pro Thr Ser Pro Arg Ser Leu Thr Leu Thr Ile His Thr Ser Tyr Val
                1365                1370                1375    
 Gly Ser Arg Ser Ser Ser Asn Met Ala Ile Val Glu Val Lys Met Leu
            1380                1385                1390        
 Ser Gly Phe Ser Pro Met Glu Gly Thr Asn Gln Leu Leu Leu Gln Gln
        1395                1400                1405            
 Pro Leu Val Lys Lys Val Glu Phe Gly Thr Asp Thr Leu Asn Ile Tyr
    1410                1415                1420                
 Leu Asp Glu Leu Ile Lys Asn Thr Gln Thr Tyr Thr Phe Thr Ile Ser
1425                1430                1435                1440
 Gln Ser Val Leu Val Thr Asn Leu Lys Pro Ala Thr Ile Lys Val Tyr
                1445                1450                1455    
 Asp Tyr Tyr Leu Pro Gly Ser Phe Lys Leu Ser Gln Tyr Thr Ile Val
            1460                1465                1470        
 Trp Ser Met Asn Asn Asp Ser Ile Val Asp Ser Val Ala Arg His Pro
        1475                1480                1485            
 Glu Pro Pro Pro Phe Lys Thr Glu Ala Phe Ile Pro Ser Leu Pro Gly
    1490                1495                1500                
 Ser Val Asn Asn
1505            



      <210> 755
      <211> 428
      <212> PRT
      <213> Homo sapiens


      <400> 755
 Met Phe Thr Ile Lys Leu Leu Leu Phe Ile Val Pro Leu Val Ile Ser
   1               5                  10                  15    
 Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu
              20                  25                  30        
 Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn
          35                  40                  45            
 Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr
      50                  55                  60                
 Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln
  65                  70                  75                  80
 Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu
                  85                  90                  95    
 Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu
             100                 105                 110        
 Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu
         115                 120                 125            
 Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln
     130                 135                 140                
 Leu Thr Asn Leu Ile Gln Asn Gln Pro Glu Thr Pro Glu His Pro Glu
 145                 150                 155                 160
 Val Thr Ser Leu Lys Thr Phe Val Glu Lys Gln Asp Asn Ser Ile Lys
                 165                 170                 175    
 Asp Leu Leu Gln Thr Val Glu Asp Gln Tyr Lys Gln Leu Asn Gln Gln
             180                 185                 190        
 His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Arg Thr Ser Ile
         195                 200                 205            
 Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro Arg
     210                 215                 220                
 Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp
 225                 230                 235                 240
 Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr
                 245                 250                 255    
 Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val
             260                 265                 270        
 Tyr Cys Asp Val Ile Ser Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile
         275                 280                 285            
 Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu
     290                 295                 300                
 Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly
 305                 310                 315                 320
 Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn
                 325                 330                 335    
 Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp
             340                 345                 350        
 Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly
         355                 360                 365            
 Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys
     370                 375                 380                
 Tyr Asn Lys Pro Arg Ala Lys Ser Lys Pro Glu Arg Arg Arg Gly Leu
 385                 390                 395                 400
 Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys
                 405                 410                 415    
 Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu
             420                 425            



      <210> 756
      <211> 1028
      <212> PRT
      <213> Homo sapiens


      <400> 756
 Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys
   1               5                  10                  15    
 Leu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro
              20                  25                  30        
 Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu
          35                  40                  45            
 Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Tyr Arg Trp Lys Leu
      50                  55                  60                
 Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val
  65                  70                  75                  80
 Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly
                  85                  90                  95    
 Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg
             100                 105                 110        
 Glu Ala Lys Leu Gln Phe Ala Tyr Leu Glu Asn Phe Lys Thr Lys Met
         115                 120                 125            
 Arg Ser Thr Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Leu Cys
     130                 135                 140                
 Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn
 145                 150                 155                 160
 Glu Tyr Pro Ser Phe Val Glu Glu Asp Ser Arg Arg Phe Val Ser Gln
                 165                 170                 175    
 Glu Thr Gly His Leu Tyr Ile Ser Lys Val Glu Pro Ser Asp Val Gly
             180                 185                 190        
 Asn Tyr Thr Cys Val Val Thr Ser Met Val Thr Asn Ala Arg Val Leu
         195                 200                 205            
 Gly Ser Pro Thr Pro Leu Val Leu Arg Ser Asp Gly Val Met Gly Glu
     210                 215                 220                
 Tyr Glu Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Leu Pro Ala Ala
 225                 230                 235                 240
 Lys Gly Ser Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Ile
                 245                 250                 255    
 Pro Gln Ile Asn Trp Arg Arg Ser Asp Gly Leu Pro Phe Ser Ser Lys
             260                 265                 270        
 Ile Lys Leu Arg Lys Phe Ser Gly Val Leu Glu Ile Pro Asn Phe Gln
         275                 280                 285            
 Gln Glu Asp Ala Gly Ser Tyr Glu Cys Ile Ala Glu Asn Ser Arg Gly
     290                 295                 300                
 Lys Asn Val Ala Arg Gly Arg Leu Thr Tyr Tyr Ala Lys Pro His Trp
 305                 310                 315                 320
 Val Gln Leu Ile Lys Asp Val Glu Ile Ala Val Glu Asp Ser Leu Tyr
                 325                 330                 335    
 Trp Glu Cys Arg Ala Ser Gly Lys Pro Lys Pro Ser Tyr Arg Trp Leu
             340                 345                 350        
 Lys Asn Gly Ala Ala Leu Val Leu Glu Glu Arg Thr Gln Ile Glu Asn
         355                 360                 365            
 Gly Ala Leu Thr Ile Ser Asn Leu Ser Val Thr Asp Ser Gly Met Phe
     370                 375                 380                
 Gln Cys Ile Ala Glu Asn Lys His Gly Leu Val Tyr Ser Ser Ala Glu
 385                 390                 395                 400
 Leu Lys Val Val Ala Ser Ala Pro Asp Phe Ser Lys Asn Pro Met Lys
                 405                 410                 415    
 Lys Leu Val Gln Val Gln Val Gly Ser Leu Val Ser Leu Asp Cys Lys
             420                 425                 430        
 Pro Arg Ala Ser Pro Arg Ala Leu Ser Ser Trp Lys Lys Gly Asp Val
         435                 440                 445            
 Ser Val Gln Glu His Glu Arg Ile Ser Leu Leu Asn Asp Gly Gly Leu
     450                 455                 460                
 Lys Ile Ala Asn Val Thr Lys Ala Asp Ala Gly Thr Tyr Thr Cys Met
 465                 470                 475                 480
 Ala Glu Asn Gln Phe Gly Lys Ala Asn Gly Thr Thr His Leu Val Val
                 485                 490                 495    
 Thr Glu Pro Thr Arg Ile Thr Leu Ala Pro Ser Asn Met Asp Val Ser
             500                 505                 510        
 Val Gly Glu Ser Val Ile Leu Pro Cys Gln Val Gln His Asp Pro Leu
         515                 520                 525            
 Leu Asp Ile Ile Phe Thr Trp Tyr Phe Asn Gly Ala Leu Ala Asp Phe
     530                 535                 540                
 Lys Lys Asp Gly Ser His Phe Glu Lys Val Gly Gly Ser Ser Ser Gly
 545                 550                 555                 560
 Asp Leu Met Ile Arg Asn Ile Gln Leu Lys His Ser Gly Lys Tyr Val
                 565                 570                 575    
 Cys Met Val Gln Thr Gly Val Asp Ser Val Ser Ser Ala Ala Asp Leu
             580                 585                 590        
 Ile Val Arg Gly Ser Pro Gly Pro Pro Glu Asn Val Lys Val Asp Glu
         595                 600                 605            
 Ile Thr Asp Thr Thr Ala Gln Leu Ser Trp Lys Glu Gly Lys Asp Asn
     610                 615                 620                
 His Ser Pro Val Ile Ser Tyr Ser Ile Gln Ala Arg Thr Pro Phe Ser
 625                 630                 635                 640
 Val Gly Trp Gln Thr Val Thr Thr Val Pro Glu Val Ile Asp Gly Lys
                 645                 650                 655    
 Thr His Thr Ala Thr Val Val Glu Leu Asn Pro Trp Val Glu Tyr Glu
             660                 665                 670        
 Phe Arg Val Val Ala Ser Asn Lys Ile Gly Gly Gly Glu Pro Ser Leu
         675                 680                 685            
 Pro Ser Glu Lys Val Arg Thr Glu Glu Ala Val Pro Glu Val Pro Pro
     690                 695                 700                
 Ser Glu Val Asn Gly Gly Gly Gly Ser Arg Ser Glu Leu Val Ile Thr
 705                 710                 715                 720
 Trp Asp Pro Val Pro Glu Glu Leu Gln Asn Gly Glu Gly Phe Gly Tyr
                 725                 730                 735    
 Val Val Ala Phe Arg Pro Leu Gly Val Thr Thr Trp Ile Gln Thr Val
             740                 745                 750        
 Val Thr Ser Pro Asp Thr Pro Arg Tyr Val Phe Arg Asn Glu Ser Ile
         755                 760                 765            
 Val Pro Tyr Ser Pro Tyr Glu Val Lys Val Gly Val Tyr Asn Asn Lys
     770                 775                 780                
 Gly Glu Gly Pro Phe Ser Pro Val Thr Thr Val Phe Ser Ala Glu Glu
 785                 790                 795                 800
 Glu Pro Thr Val Ala Pro Ser Gln Val Ser Ala Asn Ser Leu Ser Ser
                 805                 810                 815    
 Ser Glu Ile Glu Val Ser Trp Asn Thr Ile Pro Trp Lys Leu Ser Asn
             820                 825                 830        
 Gly His Leu Leu Gly Tyr Glu Val Arg Tyr Trp Asn Gly Gly Gly Lys
         835                 840                 845            
 Glu Glu Ser Ser Ser Lys Met Lys Val Ala Gly Asn Glu Thr Ser Ala
     850                 855                 860                
 Arg Leu Arg Gly Leu Lys Ser Asn Leu Ala Tyr Tyr Thr Ala Val Arg
 865                 870                 875                 880
 Ala Tyr Asn Ser Ala Gly Ala Gly Pro Phe Ser Ala Thr Val Asn Val
                 885                 890                 895    
 Thr Thr Lys Lys Thr Pro Pro Ser Gln Pro Pro Gly Asn Val Val Trp
             900                 905                 910        
 Asn Ala Thr Asp Thr Lys Val Leu Leu Asn Trp Glu Gln Val Lys Ala
         915                 920                 925            
 Met Glu Asn Glu Ser Glu Val Thr Gly Tyr Lys Val Phe Tyr Arg Thr
     930                 935                 940                
 Ser Ser Gln Asn Asn Val Gln Val Leu Asn Thr Asn Lys Thr Ser Ala
 945                 950                 955                 960
 Glu Leu Val Leu Pro Ile Lys Glu Asp Tyr Ile Ile Glu Val Lys Ala
                 965                 970                 975    
 Thr Thr Asp Gly Gly Asp Gly Thr Ser Ser Glu Gln Ile Arg Ile Pro
             980                 985                 990        
 Arg Ile Thr Ser Met Asp Ala Arg Gly Ser Thr Ser Ala Ile Ser Asn
         995                1000                1005            
 Val His Pro Met Ser Ser Tyr Met Pro Ile Val Leu Phe Leu Ile Val
    1010                1015                1020                
 Tyr Val Leu Trp
1025            



      <210> 757
      <211> 719
      <212> PRT
      <213> Homo sapiens


      <400> 757
 Met Glu Lys Ile Leu Phe Tyr Leu Phe Leu Ile Gly Ile Ala Val Lys
   1               5                  10                  15    
 Ala Gln Ile Cys Pro Lys Arg Cys Val Cys Gln Ile Leu Ser Pro Asn
              20                  25                  30        
 Leu Ala Thr Leu Cys Ala Lys Lys Gly Leu Leu Phe Val Pro Pro Asn
          35                  40                  45            
 Ile Asp Arg Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Val Thr
      50                  55                  60                
 Asn Ile Lys Arg Lys Asp Phe Ala Asn Met Thr Ser Leu Val Asp Leu
  65                  70                  75                  80
 Thr Leu Ser Arg Asn Thr Ile Ser Phe Ile Thr Pro His Ala Phe Ala
                  85                  90                  95    
 Asp Leu Arg Asn Leu Arg Ala Leu His Leu Asn Ser Asn Arg Leu Thr
             100                 105                 110        
 Lys Ile Thr Asn Asp Met Phe Ser Gly Leu Ser Asn Leu His His Leu
         115                 120                 125            
 Ile Leu Asn Asn Asn Gln Leu Thr Leu Ile Ser Ser Thr Ala Phe Asp
     130                 135                 140                
 Asp Val Phe Ala Leu Glu Glu Leu Asp Leu Ser Tyr Asn Asn Leu Glu
 145                 150                 155                 160
 Thr Ile Pro Trp Asp Ala Val Glu Lys Met Val Ser Leu His Thr Leu
                 165                 170                 175    
 Ser Leu Asp His Asn Met Ile Asp Asn Ile Pro Lys Gly Thr Phe Ser
             180                 185                 190        
 His Leu His Lys Met Thr Arg Leu Asp Val Thr Ser Asn Lys Leu Gln
         195                 200                 205            
 Lys Leu Pro Pro Asp Pro Leu Phe Gln Arg Ala Gln Val Leu Ala Thr
     210                 215                 220                
 Ser Gly Ile Ile Ser Pro Ser Thr Phe Ala Leu Ser Phe Gly Gly Asn
 225                 230                 235                 240
 Pro Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Ser Arg
                 245                 250                 255    
 Glu Asp Asp Leu Glu Thr Cys Ala Ser Pro Pro Leu Leu Thr Gly Arg
             260                 265                 270        
 Tyr Phe Trp Ser Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu
         275                 280                 285            
 Ile Thr Arg His Thr His Glu Met Arg Val Leu Glu Gly Gln Arg Ala
     290                 295                 300                
 Thr Leu Arg Cys Lys Ala Arg Gly Asp Pro Glu Pro Ala Ile His Trp
 305                 310                 315                 320
 Ile Ser Pro Glu Gly Lys Leu Ile Ser Asn Ala Thr Arg Ser Leu Val
                 325                 330                 335    
 Tyr Asp Asn Gly Thr Leu Asp Ile Leu Ile Thr Thr Val Lys Asp Thr
             340                 345                 350        
 Gly Ala Phe Thr Cys Ile Ala Ser Asn Pro Ala Gly Glu Ala Thr Gln
         355                 360                 365            
 Ile Val Asp Leu His Ile Ile Lys Leu Pro His Leu Leu Asn Ser Thr
     370                 375                 380                
 Asn His Ile His Glu Pro Asp Pro Gly Ser Ser Asp Ile Ser Thr Ser
 385                 390                 395                 400
 Thr Lys Ser Gly Ser Asn Thr Ser Ser Ser Asn Gly Asp Thr Lys Leu
                 405                 410                 415    
 Ser Gln Asp Lys Ile Val Val Ala Glu Ala Thr Ser Ser Thr Ala Leu
             420                 425                 430        
 Leu Lys Phe Asn Phe Gln Arg Asn Ile Pro Gly Ile Arg Met Phe Gln
         435                 440                 445            
 Ile Gln Tyr Asn Gly Thr Tyr Asp Asp Thr Leu Val Tyr Arg Met Ile
     450                 455                 460                
 Pro Pro Thr Ser Lys Thr Phe Leu Val Asn Asn Leu Ala Ala Gly Thr
 465                 470                 475                 480
 Met Tyr Asp Leu Cys Val Leu Ala Ile Tyr Asp Asp Gly Ile Thr Ser
                 485                 490                 495    
 Leu Thr Ala Thr Arg Val Val Gly Cys Ile Gln Phe Thr Thr Glu Gln
             500                 505                 510        
 Asp Tyr Val Arg Cys His Phe Met Gln Ser Gln Phe Leu Gly Gly Thr
         515                 520                 525            
 Met Ile Ile Ile Ile Gly Gly Ile Ile Val Ala Ser Val Leu Val Phe
     530                 535                 540                
 Ile Ile Ile Leu Met Ile Arg Tyr Lys Val Cys Asn Asn Asn Gly Gln
 545                 550                 555                 560
 His Lys Val Thr Lys Val Ser Asn Val Tyr Ser Gln Thr Asn Gly Ala
                 565                 570                 575    
 Gln Ile Gln Gly Cys Ser Val Thr Leu Pro Gln Ser Val Ser Lys Gln
             580                 585                 590        
 Ala Val Gly His Glu Glu Asn Ala Gln Cys Cys Lys Ala Thr Ser Asp
         595                 600                 605            
 Asn Val Ile Gln Ser Ser Glu Thr Cys Ser Ser Gln Asp Ser Ser Thr
     610                 615                 620                
 Thr Thr Ser Ala Leu Pro Pro Ser Trp Thr Ser Ser Thr Ser Val Ser
 625                 630                 635                 640
 Gln Lys Gln Lys Arg Lys Thr Gly Thr Lys Pro Ser Thr Glu Pro Gln
                 645                 650                 655    
 Asn Glu Ala Val Thr Asn Val Glu Ser Gln Asn Thr Asn Arg Asn Asn
             660                 665                 670        
 Ser Thr Ala Leu Gln Leu Ala Ser Arg Pro Pro Asp Ser Val Thr Glu
         675                 680                 685            
 Gly Pro Thr Ser Lys Arg Ala His Ile Lys Pro Asn Ala Leu Leu Thr
     690                 695                 700                
 Asn Val Asp Gln Ile Val Gln Glu Thr Gln Arg Leu Glu Leu Ile
 705                 710                 715                



      <210> 758
      <211> 779
      <212> PRT
      <213> Homo sapiens


      <400> 758
 Met Glu Lys Ile Leu Phe Tyr Leu Phe Leu Ile Gly Ile Ala Val Lys
   1               5                  10                  15    
 Ala Gln Ile Cys Pro Lys Arg Cys Val Cys Gln Ile Leu Ser Pro Asn
              20                  25                  30        
 Leu Ala Thr Leu Cys Ala Lys Lys Gly Leu Leu Phe Val Pro Pro Asn
          35                  40                  45            
 Ile Asp Arg Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Val Thr
      50                  55                  60                
 Asn Ile Lys Arg Lys Asp Phe Ala Asn Met Thr Ser Leu Val Asp Leu
  65                  70                  75                  80
 Thr Leu Ser Arg Asn Thr Ile Ser Phe Ile Thr Pro His Ala Phe Ala
                  85                  90                  95    
 Asp Leu Arg Asn Leu Arg Ala Leu His Leu Asn Ser Asn Arg Leu Thr
             100                 105                 110        
 Lys Ile Thr Asn Asp Met Phe Ser Gly Leu Ser Asn Leu His His Leu
         115                 120                 125            
 Ile Leu Asn Asn Asn Gln Leu Thr Leu Ile Ser Ser Thr Ala Phe Asp
     130                 135                 140                
 Asp Val Phe Ala Leu Glu Glu Leu Asp Leu Ser Tyr Asn Asn Leu Glu
 145                 150                 155                 160
 Thr Ile Pro Trp Asp Ala Val Glu Lys Met Val Ser Leu His Thr Leu
                 165                 170                 175    
 Ser Leu Asp His Asn Met Ile Asp Asn Ile Pro Lys Gly Thr Phe Ser
             180                 185                 190        
 His Leu His Lys Met Thr Arg Leu Asp Val Thr Ser Asn Lys Leu Gln
         195                 200                 205            
 Lys Leu Pro Pro Asp Pro Leu Phe Gln Arg Ala Gln Val Leu Ala Thr
     210                 215                 220                
 Ser Gly Ile Ile Ser Pro Ser Thr Phe Ala Leu Ser Phe Gly Gly Asn
 225                 230                 235                 240
 Pro Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Ser Arg
                 245                 250                 255    
 Glu Asp Asp Leu Glu Thr Cys Ala Ser Pro Pro Leu Leu Thr Gly Arg
             260                 265                 270        
 Tyr Phe Trp Ser Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu
         275                 280                 285            
 Ile Thr Arg His Thr His Glu Met Arg Val Leu Glu Gly Gln Arg Ala
     290                 295                 300                
 Thr Leu Arg Cys Lys Ala Arg Gly Asp Pro Glu Pro Ala Ile His Trp
 305                 310                 315                 320
 Ile Ser Pro Glu Gly Lys Leu Ile Ser Asn Ala Thr Arg Ser Leu Val
                 325                 330                 335    
 Tyr Asp Asn Gly Thr Leu Asp Ile Leu Ile Thr Thr Val Lys Asp Thr
             340                 345                 350        
 Gly Ala Phe Thr Cys Ile Ala Ser Asn Pro Ala Gly Glu Ala Thr Gln
         355                 360                 365            
 Ile Val Asp Leu His Ile Ile Lys Leu Pro His Leu Leu Asn Ser Thr
     370                 375                 380                
 Asn His Ile His Glu Pro Asp Pro Gly Ser Ser Asp Ile Ser Thr Ser
 385                 390                 395                 400
 Thr Lys Ser Gly Ser Asn Thr Ser Ser Ser Asn Gly Asp Thr Lys Leu
                 405                 410                 415    
 Ser Gln Asp Lys Ile Val Val Ala Glu Ala Thr Ser Ser Thr Ala Leu
             420                 425                 430        
 Leu Lys Phe Asn Phe Gln Arg Asn Ile Pro Gly Ile Arg Met Phe Gln
         435                 440                 445            
 Ile Gln Tyr Asn Gly Thr Tyr Asp Asp Thr Leu Val Tyr Arg Leu Ser
     450                 455                 460                
 Leu Arg Met Ile Pro Pro Thr Ser Lys Thr Phe Leu Val Asn Asn Leu
 465                 470                 475                 480
 Ala Ala Gly Thr Met Tyr Asp Leu Cys Val Leu Ala Ile Tyr Asp Asp
                 485                 490                 495    
 Gly Ile Thr Ser Leu Thr Ala Thr Arg Val Val Gly Cys Ile Gln Phe
             500                 505                 510        
 Thr Thr Glu Gln Asp Tyr Val Arg Cys His Phe Met Gln Ser Gln Phe
         515                 520                 525            
 Leu Gly Gly Thr Met Ile Ile Ile Ile Gly Gly Ile Ile Val Ala Ser
     530                 535                 540                
 Val Leu Val Phe Ile Ile Ile Leu Met Ile Arg Tyr Lys Val Cys Asn
 545                 550                 555                 560
 Asn Asn Gly Gln His Lys Val Thr Lys Val Ser Asn Val Tyr Ser Gln
                 565                 570                 575    
 Thr Asn Gly Ala Gln Ile Gln Gly Cys Ser Val Thr Leu Pro Gln Ser
             580                 585                 590        
 Val Ser Lys Gln Ala Val Gly His Glu Glu Asn Ala Gln Cys Cys Lys
         595                 600                 605            
 Ala Thr Ser Asp Asn Val Ile Gln Ser Ser Glu Thr Cys Ser Ser Gln
     610                 615                 620                
 Asp Ser Ser Thr Thr Thr Ser Ala Leu Pro Pro Ser Trp Thr Ser Ser
 625                 630                 635                 640
 Thr Ser Val Ser Gln Lys Gln Lys Arg Lys Thr Gly Thr Lys Pro Ser
                 645                 650                 655    
 Thr Glu Pro Gln Asn Glu Ala Val Thr Asn Val Glu Ser Gln Asn Thr
             660                 665                 670        
 Asn Arg Asn Asn Ser Thr Ala Leu Gln Leu Ala Ser Arg Pro Pro Asp
         675                 680                 685            
 Ser Val Thr Glu Gly Pro Thr Ser Lys Arg Ala His Ile Lys Pro Ser
     690                 695                 700                
 Lys Phe Ile Thr Leu Pro Ala Glu Arg Ser Gly Ala Arg His Lys Tyr
 705                 710                 715                 720
 Ser Leu Asn Gly Glu Leu Lys Glu Tyr Tyr Cys Tyr Ile Asn Ser Pro
                 725                 730                 735    
 Asn Thr Cys Gly Leu Phe Pro Lys Arg Ser Met Ser Met Asn Val Met
             740                 745                 750        
 Phe Ile Gln Ser Asp Cys Ser Asp Gly His Ser Ala Lys Gly Asn Phe
         755                 760                 765            
 Ser Asn Ser Glu Gly Leu Leu Glu Ser Ser Val
     770                 775                



      <210> 759
      <211> 1346
      <212> PRT
      <213> Homo sapiens


      <400> 759
 Met Lys Ser Pro Arg Arg Thr Thr Leu Cys Leu Met Phe Ile Val Ile
   1               5                  10                  15    
 Tyr Ser Ser Lys Ala Ala Leu Asn Trp Asn Tyr Glu Ser Thr Ile His
              20                  25                  30        
 Pro Leu Ser Leu His Glu His Glu Pro Ala Gly Glu Glu Ala Leu Arg
          35                  40                  45            
 Gln Lys Arg Ala Val Ala Thr Lys Ser Pro Thr Ala Glu Glu Tyr Thr
      50                  55                  60                
 Val Asn Ile Glu Ile Ser Phe Glu Asn Ala Ser Phe Leu Asp Pro Ile
  65                  70                  75                  80
 Lys Ala Tyr Leu Asn Ser Leu Ser Phe Pro Ile His Gly Asn Asn Thr
                  85                  90                  95    
 Asp Gln Ile Thr Asp Ile Leu Ser Ile Asn Val Thr Thr Val Cys Arg
             100                 105                 110        
 Pro Ala Gly Asn Glu Ile Trp Cys Ser Cys Glu Thr Gly Tyr Gly Trp
         115                 120                 125            
 Pro Arg Glu Arg Cys Leu His Asn Leu Ile Cys Gln Glu Arg Asp Val
     130                 135                 140                
 Phe Leu Pro Gly His His Ser Ser Cys Leu Lys Glu Leu Pro Pro Asn
 145                 150                 155                 160
 Gly Pro Phe Cys Leu Leu Gln Glu Asp Val Thr Leu Asn Met Arg Val
                 165                 170                 175    
 Arg Leu Asn Val Gly Phe Gln Glu Asp Leu Met Asn Thr Ser Ser Ala
             180                 185                 190        
 Leu Tyr Arg Ser Tyr Lys Thr Asp Leu Glu Thr Ala Phe Arg Lys Gly
         195                 200                 205            
 Tyr Gly Ile Leu Pro Gly Phe Lys Gly Val Thr Val Thr Gly Phe Lys
     210                 215                 220                
 Ser Gly Ser Val Val Val Thr Tyr Glu Val Lys Thr Thr Pro Pro Ser
 225                 230                 235                 240
 Leu Glu Leu Ile His Lys Ala Asn Glu Gln Val Val Gln Ser Leu Asn
                 245                 250                 255    
 Gln Thr Tyr Lys Met Asp Tyr Asn Ser Phe Gln Ala Val Thr Ile Asn
             260                 265                 270        
 Glu Ser Asn Phe Phe Val Thr Pro Glu Ile Ile Phe Glu Gly Asp Thr
         275                 280                 285            
 Val Ser Leu Val Cys Glu Lys Glu Val Leu Ser Ser Asn Val Ser Trp
     290                 295                 300                
 Arg Tyr Glu Glu Gln Gln Leu Glu Ile Gln Asn Ser Ser Arg Phe Ser
 305                 310                 315                 320
 Ile Tyr Thr Ala Leu Phe Asn Asn Met Thr Ser Val Ser Lys Leu Thr
                 325                 330                 335    
 Ile His Asn Ile Thr Pro Gly Asp Ala Gly Glu Tyr Val Cys Lys Leu
             340                 345                 350        
 Ile Leu Asp Ile Phe Glu Tyr Glu Cys Lys Lys Lys Ile Asp Val Met
         355                 360                 365            
 Pro Ile Gln Ile Leu Ala Asn Glu Glu Met Lys Val Met Cys Asp Asn
     370                 375                 380                
 Asn Pro Val Ser Leu Asn Cys Cys Ser Gln Gly Asn Val Asn Trp Ser
 385                 390                 395                 400
 Lys Val Glu Trp Lys Gln Glu Gly Lys Ile Asn Ile Pro Gly Thr Pro
                 405                 410                 415    
 Glu Thr Asp Ile Asp Ser Ser Cys Ser Arg Tyr Thr Leu Lys Ala Asp
             420                 425                 430        
 Gly Thr Gln Cys Pro Ser Gly Ser Ser Gly Thr Thr Val Ile Tyr Thr
         435                 440                 445            
 Cys Glu Phe Ile Ser Ala Tyr Gly Ala Arg Gly Ser Ala Asn Ile Lys
     450                 455                 460                
 Val Thr Phe Ile Ser Val Ala Asn Leu Thr Ile Thr Pro Asp Pro Ile
 465                 470                 475                 480
 Ser Val Ser Glu Gly Gln Asn Phe Ser Ile Lys Cys Ile Ser Asp Val
                 485                 490                 495    
 Ser Asn Tyr Asp Glu Val Tyr Trp Asn Thr Ser Ala Gly Ile Lys Ile
             500                 505                 510        
 Tyr Gln Arg Phe Tyr Thr Thr Arg Arg Tyr Leu Asp Gly Ala Glu Ser
         515                 520                 525            
 Val Leu Thr Val Lys Thr Ser Thr Arg Glu Trp Asn Gly Thr Tyr His
     530                 535                 540                
 Cys Ile Phe Arg Tyr Lys Asn Ser Tyr Ser Ile Ala Thr Lys Asp Val
 545                 550                 555                 560
 Ile Val His Pro Leu Pro Leu Lys Leu Asn Ile Met Val Asp Pro Leu
                 565                 570                 575    
 Glu Ala Thr Val Ser Cys Ser Gly Ser His His Ile Lys Cys Cys Ile
             580                 585                 590        
 Glu Glu Asp Gly Asp Tyr Lys Val Thr Phe His Met Gly Ser Ser Ser
         595                 600                 605            
 Leu Pro Ala Ala Lys Glu Val Asn Lys Lys Gln Val Cys Tyr Lys His
     610                 615                 620                
 Asn Phe Asn Ala Ser Ser Val Ser Trp Cys Ser Lys Thr Val Asp Val
 625                 630                 635                 640
 Cys Cys His Phe Thr Asn Ala Ala Asn Asn Ser Val Trp Ser Pro Ser
                 645                 650                 655    
 Met Lys Leu Asn Leu Val Pro Gly Glu Asn Ile Thr Cys Gln Asp Pro
             660                 665                 670        
 Val Ile Gly Val Gly Glu Pro Gly Lys Val Ile Gln Lys Leu Cys Arg
         675                 680                 685            
 Phe Ser Asn Val Pro Ser Ser Pro Glu Ser Pro Ile Gly Gly Thr Ile
     690                 695                 700                
 Thr Tyr Lys Cys Val Gly Ser Gln Trp Glu Glu Lys Arg Asn Asp Cys
 705                 710                 715                 720
 Ile Ser Ala Pro Ile Asn Ser Leu Leu Gln Met Ala Lys Ala Leu Ile
                 725                 730                 735    
 Lys Ser Pro Ser Gln Asp Glu Met Leu Pro Thr Tyr Leu Lys Asp Leu
             740                 745                 750        
 Ser Ile Ser Ile Asp Lys Ala Glu His Glu Ile Ser Ser Ser Pro Gly
         755                 760                 765            
 Ser Leu Gly Ala Ile Ile Asn Ile Leu Asp Leu Leu Ser Thr Val Pro
     770                 775                 780                
 Thr Gln Val Asn Ser Glu Met Met Thr His Val Leu Ser Thr Val Asn
 785                 790                 795                 800
 Val Ile Leu Gly Lys Pro Val Leu Asn Thr Trp Lys Val Leu Gln Gln
                 805                 810                 815    
 Gln Trp Thr Asn Gln Ser Ser Gln Leu Leu His Ser Val Glu Arg Phe
             820                 825                 830        
 Ser Gln Ala Leu Gln Ser Gly Asp Ser Pro Pro Leu Ser Phe Ser Gln
         835                 840                 845            
 Thr Asn Val Gln Met Ser Ser Thr Val Ile Lys Ser Ser His Pro Glu
     850                 855                 860                
 Thr Tyr Gln Gln Arg Phe Val Phe Pro Tyr Phe Asp Leu Trp Gly Asn
 865                 870                 875                 880
 Val Val Ile Asp Lys Ser Tyr Leu Glu Asn Leu Gln Ser Asp Ser Ser
                 885                 890                 895    
 Ile Val Thr Met Ala Phe Pro Thr Leu Gln Ala Ile Leu Ala Gln Asp
             900                 905                 910        
 Ile Gln Glu Asn Asn Phe Ala Glu Ser Leu Val Met Thr Thr Thr Val
         915                 920                 925            
 Ser His Asn Thr Thr Met Pro Phe Arg Ile Ser Met Thr Phe Lys Asn
     930                 935                 940                
 Asn Ser Pro Ser Gly Gly Glu Thr Lys Cys Val Phe Trp Asn Phe Arg
 945                 950                 955                 960
 Leu Ala Asn Asn Thr Gly Gly Trp Asp Ser Ser Gly Cys Tyr Val Glu
                 965                 970                 975    
 Glu Gly Asp Gly Asp Asn Val Thr Cys Ile Cys Asp His Leu Thr Ser
             980                 985                 990        
 Phe Ser Ile Leu Met Ser Pro Asp Ser Pro Asp Pro Ser Ser Leu Leu
         995                1000                1005            
 Gly Ile Leu Leu Asp Ile Ile Ser Tyr Val Gly Val Gly Phe Ser Ile
    1010                1015                1020                
 Leu Ser Leu Ala Ala Cys Leu Val Val Glu Ala Val Val Trp Lys Ser
1025                1030                1035                1040
 Val Thr Lys Asn Arg Thr Ser Tyr Met Arg His Thr Cys Ile Val Asn
                1045                1050                1055    
 Ile Ala Ala Ser Leu Leu Val Ala Asn Thr Trp Phe Ile Val Val Ala
            1060                1065                1070        
 Ala Ile Gln Asp Asn Arg Tyr Ile Leu Cys Lys Thr Ala Cys Val Ala
        1075                1080                1085            
 Ala Thr Phe Phe Ile His Phe Phe Tyr Leu Ser Val Phe Phe Trp Met
    1090                1095                1100                
 Leu Thr Leu Gly Leu Met Leu Phe Tyr Arg Leu Val Phe Ile Leu His
1105                1110                1115                1120
 Glu Thr Ser Arg Ser Thr Gln Lys Ala Ile Ala Phe Cys Leu Gly Tyr
                1125                1130                1135    
 Gly Cys Pro Leu Ala Ile Ser Val Ile Thr Leu Gly Ala Thr Gln Pro
            1140                1145                1150        
 Arg Glu Val Tyr Thr Arg Lys Asn Val Cys Trp Leu Asn Trp Glu Asp
        1155                1160                1165            
 Thr Lys Ala Leu Leu Ala Phe Ala Ile Pro Ala Leu Ile Ile Val Val
    1170                1175                1180                
 Val Asn Ile Thr Ile Thr Ile Val Val Ile Thr Lys Ile Leu Arg Pro
1185                1190                1195                1200
 Ser Ile Gly Asp Lys Pro Cys Lys Gln Glu Lys Ser Ser Leu Phe Gln
                1205                1210                1215    
 Ile Ser Lys Ser Ile Gly Val Leu Thr Pro Leu Leu Gly Leu Thr Trp
            1220                1225                1230        
 Gly Phe Gly Leu Thr Thr Val Phe Pro Gly Thr Asn Leu Val Phe His
        1235                1240                1245            
 Ile Ile Phe Ala Ile Leu Asn Val Phe Gln Gly Leu Phe Ile Leu Leu
    1250                1255                1260                
 Phe Gly Cys Leu Trp Asp Leu Lys Val Gln Glu Ala Leu Leu Asn Lys
1265                1270                1275                1280
 Phe Ser Leu Ser Arg Trp Ser Ser Gln His Ser Lys Ser Thr Ser Leu
                1285                1290                1295    
 Gly Ser Ser Thr Pro Val Phe Ser Met Ser Ser Pro Ile Ser Arg Arg
            1300                1305                1310        
 Phe Asn Asn Leu Phe Gly Lys Thr Gly Thr Tyr Asn Val Ser Thr Pro
        1315                1320                1325            
 Glu Ala Thr Ser Ser Ser Leu Glu Asn Ser Ser Ser Ala Ser Ser Leu
    1330                1335                1340                
 Leu Asn
1345    



      <210> 760
      <211> 438
      <212> PRT
      <213> Homo sapiens


      <400> 760
 Met Asn Thr Leu Ser Ser Thr Gly Gln Gly Asn Thr Glu Val Ile His
   1               5                  10                  15    
 Thr Gly Thr Leu Gln Arg Gln Ala Ser Tyr His Ile Gly Ala Phe Cys
              20                  25                  30        
 Ser Gln Glu Ile Glu Lys Asp Ile His Asp Phe Val Phe Gln Trp Gln
          35                  40                  45            
 Glu Asp Glu Thr Asn Asp His Glu Ala Pro Met Thr Glu Ile Lys Lys
      50                  55                  60                
 Leu Thr Ser Ser Thr Asp Arg Tyr Asp Gln Arg His Ala Gly Asn Lys
  65                  70                  75                  80
 Pro Ile Lys Gly Gln Leu Glu Ser Arg Phe His Leu His Leu Arg Arg
                  85                  90                  95    
 His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys
             100                 105                 110        
 Glu Lys Val Phe Ser Cys Lys Ser His Leu Glu Ile His Arg Ile Ile
         115                 120                 125            
 His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Val Cys Asp Lys Ala Phe
     130                 135                 140                
 Lys His Asp Ser His Leu Ala Lys His Thr Arg Ile His Arg Gly Asp
 145                 150                 155                 160
 Lys His Tyr Thr Cys Asn Glu Cys Gly Lys Val Phe Asp Gln Lys Ala
                 165                 170                 175    
 Thr Leu Ala Cys His His Arg Ser His Thr Gly Glu Lys Pro Tyr Lys
             180                 185                 190        
 Cys Asn Glu Cys Gly Lys Thr Phe Ser Gln Thr Ser His Leu Val Tyr
         195                 200                 205            
 His His Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys
     210                 215                 220                
 Gly Lys Thr Phe Ala Arg Asn Ser Val Leu Val Ile His Lys Ala Val
 225                 230                 235                 240
 His Thr Ala Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe
                 245                 250                 255    
 Lys Gln Arg Ala Thr Leu Ala Gly His Arg Arg Val His Thr Gly Glu
             260                 265                 270        
 Lys Pro Tyr Arg Cys Glu Glu Cys Asp Lys Val Phe Ser Arg Lys Ser
         275                 280                 285            
 His Leu Glu Arg His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Lys
     290                 295                 300                
 Cys Lys Val Cys Asp Lys Ala Phe Arg Ser Asp Ser Arg Leu Ala Glu
 305                 310                 315                 320
 His Gln Arg Val His Thr Gly Glu Arg Pro Tyr Thr Cys Asn Glu Cys
                 325                 330                 335    
 Gly Lys Val Phe Ser Thr Lys Ala Tyr Leu Ala Cys His Gln Lys Leu
             340                 345                 350        
 His Thr Gly Glu Lys Leu Tyr Glu Cys Glu Glu Cys Asp Lys Val Tyr
         355                 360                 365            
 Ile Arg Lys Ser His Leu Glu Arg His Arg Arg Ile His Thr Gly Glu
     370                 375                 380                
 Lys Pro His Lys Cys Gly Asp Cys Gly Lys Ala Phe Asn Ser Pro Ser
 385                 390                 395                 400
 His Leu Ile Arg His Gln Arg Ile His Thr Gly Gln Lys Ser Tyr Lys
                 405                 410                 415    
 Cys His Gln Cys Gly Lys Val Phe Ser Leu Arg Ser Pro Leu Ala Glu
             420                 425                 430        
 Tyr Gln Lys Ile His Phe
         435            



      <210> 761
      <211> 1006
      <212> PRT
      <213> Homo sapiens


      <400> 761
 Met Gly Ile Leu Ser Trp Lys Asp Ser Lys His Ser Leu Asn Asn Glu
   1               5                  10                  15    
 Lys Ile Ile Leu Arg Gly Cys Ile Leu Arg Asn Thr Ser Trp Cys Phe
              20                  25                  30        
 Gly Met Val Ile Phe Ala Gly Pro Asp Thr Lys Leu Met Gln Asn Ser
          35                  40                  45            
 Gly Lys Thr Lys Phe Lys Arg Thr Ser Ile Asp Arg Leu Met Asn Thr
      50                  55                  60                
 Leu Val Leu Trp Val Ile Phe Gly Phe Leu Ile Cys Leu Gly Ile Ile
  65                  70                  75                  80
 Leu Ala Ile Gly Asn Ser Ile Trp Glu Ser Gln Thr Gly Asp Gln Phe
                  85                  90                  95    
 Arg Thr Phe Leu Phe Trp Asn Glu Gly Glu Lys Ser Ser Val Phe Ser
             100                 105                 110        
 Gly Phe Leu Thr Phe Trp Ser Tyr Ile Ile Ile Leu Asn Thr Val Val
         115                 120                 125            
 Pro Ile Ser Leu Tyr Val Ser Val Glu Val Ile Arg Leu Gly His Ser
     130                 135                 140                
 Tyr Phe Ile Asn Trp Asp Arg Lys Met Tyr Tyr Ser Arg Lys Ala Ile
 145                 150                 155                 160
 Pro Ala Val Ala Arg Thr Thr Thr Leu Asn Glu Glu Leu Gly Gln Ile
                 165                 170                 175    
 Glu Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Ile Met
             180                 185                 190        
 Thr Phe Lys Arg Cys Ser Ile Asn Gly Arg Ile Tyr Gly Glu Val His
         195                 200                 205            
 Asp Asp Leu Asp Gln Lys Thr Glu Ile Thr Gln Glu Lys Glu Pro Val
     210                 215                 220                
 Asp Phe Ser Val Lys Ser Gln Ala Asp Arg Glu Phe Gln Phe Phe Asp
 225                 230                 235                 240
 His Asn Leu Met Glu Ser Ile Lys Met Gly Asp Pro Lys Val His Glu
                 245                 250                 255    
 Phe Leu Arg Leu Leu Ala Leu Cys His Thr Val Met Ser Glu Glu Asn
             260                 265                 270        
 Ser Ala Gly Lys Gly Glu Leu Ile Tyr Gln Val Gln Ser Pro Asp Glu
         275                 280                 285            
 Gly Ala Leu Val Thr Ala Ala Arg Asn Phe Gly Phe Ile Phe Lys Ser
     290                 295                 300                
 Arg Thr Pro Glu Thr Ile Thr Ile Glu Glu Leu Gly Thr Leu Val Thr
 305                 310                 315                 320
 Tyr Gln Leu Leu Ala Phe Leu Asp Phe Asn Asn Thr Arg Lys Arg Met
                 325                 330                 335    
 Ser Val Ile Val Arg Asn Pro Glu Gly Gln Ile Lys Leu Tyr Ser Lys
             340                 345                 350        
 Gly Ala Asp Thr Ile Leu Phe Glu Lys Leu His Pro Ser Asn Glu Val
         355                 360                 365            
 Leu Leu Ser Leu Thr Ser Asp His Leu Ser His Leu Trp Gln Glu Phe
     370                 375                 380                
 Ala Gly Glu Gly Leu Arg Thr Leu Ala Ile Ala Tyr Arg Asp Leu Asp
 385                 390                 395                 400
 Asp Lys Tyr Phe Lys Glu Trp His Lys Met Leu Glu Asp Ala Asn Ala
                 405                 410                 415    
 Ala Thr Glu Glu Arg Asp Glu Arg Ile Ala Gly Leu Tyr Glu Glu Ile
             420                 425                 430        
 Glu Arg Asp Leu Met Leu Leu Gly Ala Thr Ala Val Glu Asp Lys Leu
         435                 440                 445            
 Gln Glu Gly Val Ile Glu Thr Val Thr Ser Leu Ser Leu Ala Asn Ile
     450                 455                 460                
 Lys Ile Trp Val Leu Thr Gly Asp Lys Gln Glu Thr Ala Ile Asn Ile
 465                 470                 475                 480
 Gly Tyr Ala Cys Asn Met Leu Thr Asp Asp Met Asn Asp Val Phe Val
                 485                 490                 495    
 Ile Ala Gly Asn Asn Ala Val Glu Val Arg Glu Glu Arg Asn Phe Ser
             500                 505                 510        
 Asn Gly His Val Val Cys Glu Lys Lys Gln Gln Leu Glu Leu Asp Ser
         515                 520                 525            
 Ile Val Glu Glu Thr Ile Thr Gly Asp Tyr Ala Leu Ile Ile Asn Gly
     530                 535                 540                
 His Ser Leu Ala His Ala Leu Glu Ser Asp Val Lys Asn Asp Leu Leu
 545                 550                 555                 560
 Glu Leu Ala Cys Met Cys Lys Thr Val Ile Cys Cys Arg Val Thr Pro
                 565                 570                 575    
 Leu Gln Lys Ala Gln Val Val Glu Leu Val Lys Lys Tyr Arg Asn Ala
             580                 585                 590        
 Val Thr Leu Ala Ile Gly Asp Gly Ala Asn Asp Val Ser Met Ile Lys
         595                 600                 605            
 Ser Lys Arg Ile His Ile Gly Val Gly Ile Ser Gly Gln Glu Gly Leu
     610                 615                 620                
 Gln Ala Val Leu Ala Ser Asp Tyr Ser Phe Ala Gln Phe Arg Tyr Leu
 625                 630                 635                 640
 Gln Arg Leu Leu Leu Val His Gly Arg Trp Ser Tyr Phe Arg Met Cys
                 645                 650                 655    
 Lys Phe Leu Cys Tyr Phe Phe Tyr Lys Asn Phe Ala Phe Thr Leu Val
             660                 665                 670        
 His Phe Trp Phe Gly Phe Phe Cys Gly Phe Ser Ala Gln Val Val Tyr
         675                 680                 685            
 Asp Gln Trp Phe Ile Thr Leu Phe Asn Ile Val Tyr Thr Ser Leu Pro
     690                 695                 700                
 Val Leu Ala Met Gly Ile Phe Asp Gln Asp Val Ser Asp Gln Asn Ser
 705                 710                 715                 720
 Val Asp Cys Pro Gln Leu Tyr Lys Pro Gly Gln Leu Asn Leu Leu Phe
                 725                 730                 735    
 Asn Lys Arg Lys Phe Phe Ile Cys Val Leu His Gly Ile Tyr Thr Ser
             740                 745                 750        
 Leu Val Leu Phe Phe Ile Pro Tyr Gly Ala Phe Tyr Asn Val Ala Gly
         755                 760                 765            
 Glu Asp Gly Gln His Ile Ala Asp Tyr Gln Ser Phe Ala Val Thr Met
     770                 775                 780                
 Ala Thr Ser Leu Val Ile Val Val Ser Val Gln Ile Ala Leu Asp Thr
 785                 790                 795                 800
 Ser Tyr Trp Thr Phe Ile Asn His Val Phe Ile Trp Gly Ser Ile Ala
                 805                 810                 815    
 Ile Tyr Phe Ser Ile Leu Phe Thr Met His Ser Asn Gly Ile Phe Gly
             820                 825                 830        
 Ile Phe Pro Asn Gln Phe Leu Ile Gly Asn Ala Arg His Ser Leu Thr
         835                 840                 845            
 Gln Lys Cys Ile Trp Leu Val Ile Leu Leu Thr Thr Val Ala Ser Val
     850                 855                 860                
 Met Pro Val Val Ala Phe Arg Phe Leu Lys Val Asp Leu Tyr Pro Thr
 865                 870                 875                 880
 Leu Ser Asp Gln Val Ile Arg Arg Trp Gln Lys Ala Gln Lys Lys Ala
                 885                 890                 895    
 Arg Pro Pro Ser Ser Arg Arg Pro Arg Thr Arg Arg Ser Ser Ser Arg
             900                 905                 910        
 Arg Ser Gly Tyr Ala Phe Ala His Gln Glu Gly Tyr Gly Glu Leu Ile
         915                 920                 925            
 Thr Ser Gly Lys Asn Met Arg Ala Lys Asn Pro Pro Pro Thr Ser Gly
     930                 935                 940                
 Leu Glu Lys Thr His Tyr Asn Ser Thr Ser Trp Ile Glu Asn Leu Cys
 945                 950                 955                 960
 Lys Lys Thr Thr Asp Thr Val Ser Ser Phe Ser Gln Asp Lys Thr Val
                 965                 970                 975    
 Lys Thr Val Ser Gln Tyr Glu Phe Lys Pro Arg Ser Tyr Leu Phe Thr
             980                 985                 990        
 Ser Gly Gly Ala Glu Ile Leu Leu Ala Pro Glu Phe Glu Ile
         995                1000                1005    



      <210> 762
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 762
 Met Pro Trp Thr Ile Leu Leu Phe Ala Ala Gly Ser Leu Ala Ile Pro
   1               5                  10                  15    
 Ala Pro Ser Ile Arg Leu Val Pro Pro Tyr Pro Ser Ser Gln Glu Asp
              20                  25                  30        
 Pro Ile His Ile Ala Cys Met Ala Pro Gly Asn Phe Pro Gly Ala Asn
          35                  40                  45            
 Phe Thr Leu Tyr Arg Gly Gly Gln Val Val Gln Leu Leu Gln Ala Pro
      50                  55                  60                
 Thr Asp Gln Arg Gly Val Thr Phe Asn Leu Ser Gly Gly Ser Ser Lys
  65                  70                  75                  80
 Ala Pro Gly Gly Pro Phe His Cys Gln Tyr Gly Val Leu Gly Glu Leu
                  85                  90                  95    
 Asn Gln Ser Gln Leu Ser Asp Leu Ser Glu Pro Val Asn Val Ser Phe
             100                 105                 110        
 Pro Val Pro Thr Trp Ile Leu Val Leu Ser Leu Ser Leu Ala Gly Ala
         115                 120                 125            
 Leu Phe Leu Leu Ala Gly Leu Val Ala Val Ala Leu Val Val Arg Lys
     130                 135                 140                
 Val Lys Leu Arg Asn Leu Gln Lys Lys Arg Asp Arg Glu Ser Cys Trp
 145                 150                 155                 160
 Ala Gln Ile Asn Phe Asp Ser Thr Asp Met Ser Phe Asp Asn Ser Leu
                 165                 170                 175    
 Phe Thr Val Ser Ala Lys Thr Met Pro Glu Glu Asp Pro Ala Thr Leu
             180                 185                 190        
 Asp Asp His Ser Gly Thr Thr Ala Thr Pro Ser Asn Ser Arg Thr Arg
         195                 200                 205            
 Lys Arg Pro Thr Ser Thr Ser Ser Ser Pro Glu Thr Pro Glu Phe Ser
     210                 215                 220                
 Thr Phe Arg Ala Cys Gln
 225                 230



      <210> 763
      <211> 243
      <212> PRT
      <213> Homo sapiens


      <400> 763
 Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu
   1               5                  10                  15    
 Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp
              20                  25                  30        
 His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys
          35                  40                  45            
 Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile
      50                  55                  60                
 Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala
  65                  70                  75                  80
 Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser
                  85                  90                  95    
 Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys
             100                 105                 110        
 Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala
         115                 120                 125            
 Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His
     130                 135                 140                
 Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln
 145                 150                 155                 160
 Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys
                 165                 170                 175    
 Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr
             180                 185                 190        
 His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr
         195                 200                 205            
 Pro Arg Val Leu His Thr Pro Pro Phe Gly Val Val Pro Arg Glu Leu
     210                 215                 220                
 Lys Met Cys Gly Ser Phe Arg Met Glu Ala Arg Glu Pro Leu Ser Ser
 225                 230                 235                 240
 Glu Lys Ile
            



      <210> 764
      <211> 342
      <212> PRT
      <213> Homo sapiens


      <400> 764
 Met Met Arg Val Cys Trp Leu Val Arg Gln Asp Ser Arg His Gln Arg
   1               5                  10                  15    
 Ile Arg Leu Pro His Leu Glu Ala Val Val Ile Gly Arg Gly Pro Glu
              20                  25                  30        
 Thr Lys Ile Thr Asp Lys Lys Cys Ser Arg Gln Gln Val Gln Leu Lys
          35                  40                  45            
 Ala Glu Cys Asn Lys Gly Tyr Val Lys Val Lys Gln Val Gly Val Asn
      50                  55                  60                
 Pro Thr Ser Ile Asp Ser Val Val Ile Gly Lys Asp Gln Glu Val Lys
  65                  70                  75                  80
 Leu Gln Pro Gly Gln Val Leu His Met Val Asn Glu Leu Tyr Pro Tyr
                  85                  90                  95    
 Ile Val Glu Phe Glu Glu Glu Ala Lys Asn Pro Gly Leu Glu Thr His
             100                 105                 110        
 Arg Lys Arg Lys Arg Ser Gly Asn Ser Asp Ser Ile Glu Arg Asp Ala
         115                 120                 125            
 Ala Gln Glu Ala Glu Ala Gly Thr Gly Leu Glu Pro Gly Ser Asn Ser
     130                 135                 140                
 Gly Gln Cys Ser Val Pro Leu Lys Lys Gly Lys Asp Ala Pro Ile Lys
 145                 150                 155                 160
 Lys Glu Ser Leu Gly His Trp Ser Gln Gly Leu Lys Ile Ser Met Gln
                 165                 170                 175    
 Asp Pro Lys Met Gln Val Tyr Lys Asp Glu Gln Val Val Val Ile Lys
             180                 185                 190        
 Asp Lys Tyr Pro Lys Ala Arg Tyr His Trp Leu Val Leu Pro Trp Thr
         195                 200                 205            
 Ser Ile Ser Ser Leu Lys Ala Val Ala Arg Glu His Leu Glu Leu Leu
     210                 215                 220                
 Lys His Met His Thr Val Gly Glu Lys Val Ile Val Asp Phe Ala Gly
 225                 230                 235                 240
 Ser Ser Lys Leu Arg Phe Arg Leu Gly Tyr His Ala Ile Pro Ser Met
                 245                 250                 255    
 Ser His Val His Leu His Val Ile Ser Gln Asp Phe Asp Ser Pro Cys
             260                 265                 270        
 Leu Lys Asn Lys Lys His Trp Asn Ser Phe Asn Thr Glu Tyr Phe Leu
         275                 280                 285            
 Glu Ser Gln Ala Val Ile Glu Met Val Gln Glu Ala Gly Arg Val Thr
     290                 295                 300                
 Val Arg Asp Gly Met Pro Glu Leu Leu Lys Leu Pro Leu Arg Cys His
 305                 310                 315                 320
 Glu Cys Gln Gln Leu Leu Pro Ser Ile Pro Gln Leu Lys Glu His Leu
                 325                 330                 335    
 Arg Lys His Trp Thr Gln
             340        



      <210> 765
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 765
 Met Met Arg Val Cys Trp Leu Val Arg Gln Asp Ser Arg His Gln Arg
   1               5                  10                  15    
 Ile Arg Leu Pro His Leu Glu Ala Val Val Ile Gly Arg Gly Pro Glu
              20                  25                  30        
 Thr Lys Ile Thr Asp Lys Lys Cys Ser Arg Gln Gln Val Glu Ser Arg
          35                  40                  45            
 Val
    



      <210> 766
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 766
 Met Met Arg Val Cys Trp Leu Val Arg Gln Asp Ser Arg His Gln Arg
   1               5                  10                  15    
 Ile Arg Leu Pro His Leu Glu Ala Val Val Ile Gly Arg Gly Pro Glu
              20                  25                  30        
 Thr Lys Ile Thr Asp Lys Lys Cys Ser Arg Gln Gln Val Gln Leu Lys
          35                  40                  45            
 Ala Glu Cys Asn Lys Gly Tyr Val Lys Val Lys Gln Ser Leu Arg Lys
      50                  55                  60                
 Arg Gln Arg Thr Leu Ala Trp Lys His Thr Gly Arg Glu Arg Asp Gln
  65                  70                  75                  80
 Ala Thr Val Ile Leu
                  85



      <210> 767
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 767
 Met Thr Thr Ala Ala Arg Pro Thr Phe Glu Pro Ala Arg Gly Gly Arg
   1               5                  10                  15    
 Gly Lys Gly Glu Gly Asp Leu Ser Gln Leu Ser Lys Gln Tyr Ser Ser
              20                  25                  30        
 Arg Asp Leu Pro Ser His Thr Lys Ile Lys Tyr Arg Gln Thr Thr Gln
          35                  40                  45            
 Asp Ala Pro Glu Glu Val Arg Asn Arg Asp Phe Arg Arg Glu Leu Glu
      50                  55                  60                
 Glu Arg Glu Arg Ala Ala Ala Arg Glu Lys Asn Arg Asp Arg Pro Thr
  65                  70                  75                  80
 Arg Glu His Thr Thr Ser Ser Ser Val Ser Lys Lys Pro Arg Leu Asp
                  85                  90                  95    
 Gln Ile Pro Ala Ala Asn Leu Asp Ala Asp Asp Pro Leu Thr Asp Glu
             100                 105                 110        
 Glu Asp Glu Asp Phe Glu Glu Glu Ser Asp Asp Asp Asp Thr Ala Ala
         115                 120                 125            
 Leu Leu Ala Glu Leu Glu Lys Ile Lys Lys Glu Arg Ala Glu Glu Gln
     130                 135                 140                
 Ala Arg Lys Glu Gln Glu Gln Lys Ala Glu Glu Glu Arg Ile Arg Met
 145                 150                 155                 160
 Glu Asn Ile Leu Ser Gly Asn Pro Leu Leu Asn Leu Thr Gly Pro Ser
                 165                 170                 175    
 Gln Pro Gln Ala Asn Phe Lys Val Lys Arg Arg Trp Asp Asp Asp Val
             180                 185                 190        
 Val Phe Lys Asn Cys Ala Lys Gly Val Asp Asp Gln Lys Lys Asp Lys
         195                 200                 205            
 Arg Phe Val Asn Asp Thr Leu Arg Ser Glu Phe His Lys Lys Phe Met
     210                 215                 220                
 Glu Lys Tyr Ile Lys
 225                



      <210> 768
      <211> 359
      <212> PRT
      <213> Homo sapiens


      <400> 768
 Ser Ala His Asn Ser His Val Val Cys Gly Met Thr Gly Leu Pro Gln
   1               5                  10                  15    
 Arg Lys Glu Gly Gln Arg Gly Leu Leu Gln Ala Arg Val Arg Leu Lys
              20                  25                  30        
 Gly Gly Ala His Pro Gly Glu Gly Arg Val Glu Val Leu Lys Ala Ser
          35                  40                  45            
 Thr Trp Gly Thr Val Cys Asp Arg Lys Trp Asp Leu His Ala Ala Ser
      50                  55                  60                
 Val Val Cys Arg Glu Leu Gly Phe Gly Ser Ala Arg Glu Ala Leu Ser
  65                  70                  75                  80
 Gly Ala Arg Met Gly Gln Gly Met Gly Ala Ile His Leu Ser Glu Val
                  85                  90                  95    
 Arg Cys Ser Gly Gln Glu Leu Ser Leu Trp Lys Cys Pro His Lys Asn
             100                 105                 110        
 Ile Thr Ala Glu Asp Cys Ser His Ser Gln Asp Ala Gly Val Arg Cys
         115                 120                 125            
 Asn Leu Pro Tyr Thr Gly Ala Glu Thr Arg Ile Arg Leu Ser Gly Gly
     130                 135                 140                
 Arg Ser Gln His Glu Gly Arg Val Glu Val Gln Ile Gly Gly Pro Gly
 145                 150                 155                 160
 Pro Leu Arg Trp Gly Leu Ile Cys Gly Asp Asp Trp Gly Thr Leu Glu
                 165                 170                 175    
 Ala Met Val Ala Cys Arg Gln Leu Gly Leu Gly Tyr Ala Asn His Gly
             180                 185                 190        
 Leu Gln Glu Thr Trp Tyr Trp Asp Ser Gly Asn Ile Thr Glu Val Val
         195                 200                 205            
 Met Ser Gly Val Arg Cys Thr Gly Thr Glu Leu Ser Leu Asp Gln Cys
     210                 215                 220                
 Ala His His Gly Thr His Ile Thr Cys Lys Arg Thr Gly Thr Arg Phe
 225                 230                 235                 240
 Thr Ala Gly Val Ile Cys Ser Glu Thr Ala Ser Asp Leu Leu Leu His
                 245                 250                 255    
 Ser Ala Leu Val Gln Glu Thr Ala Tyr Ile Glu Asp Arg Pro Leu His
             260                 265                 270        
 Met Leu Tyr Cys Ala Ala Glu Glu Asn Cys Leu Ala Ser Ser Ala Arg
         275                 280                 285            
 Ser Ala Asn Trp Pro Tyr Gly His Arg Arg Leu Leu Arg Phe Cys Ser
     290                 295                 300                
 Gln Ile His Asn Leu Gly Arg Ala Asp Phe Arg Pro Lys Ala Gly Arg
 305                 310                 315                 320
 His Ser Trp Val Trp His Glu Cys His Gly His Tyr His Ser Thr Asp
                 325                 330                 335    
 Phe Phe Thr His Tyr Asp Ile Leu Thr Pro His Gly Thr Lys Val Ala
             340                 345                 350        
 Glu Gly His Lys Ala Ser Phe
         355                



      <210> 769
      <211> 603
      <212> PRT
      <213> Homo sapiens


      <400> 769
 Met Leu Phe Tyr Arg Lys Asn Pro Leu His Leu His Leu Val Thr Asp
   1               5                  10                  15    
 Ala Val Ala Arg Asn Ile Leu Glu Thr Leu Phe His Thr Trp Met Val
              20                  25                  30        
 Pro Ala Val Arg Val Ser Phe Tyr His Ala Asp Gln Leu Lys Pro Gln
          35                  40                  45            
 Val Ser Trp Ile Pro Asn Lys His Tyr Ser Gly Leu Tyr Gly Leu Met
      50                  55                  60                
 Lys Leu Val Leu Pro Ser Ala Leu Pro Ala Glu Leu Ala Arg Val Ile
  65                  70                  75                  80
 Val Leu Asp Thr Asp Val Thr Phe Ala Ser Asp Ile Ser Glu Leu Trp
                  85                  90                  95    
 Ala Leu Phe Ala His Phe Ser Asp Thr Gln Ala Ile Gly Leu Val Glu
             100                 105                 110        
 Asn Gln Ser Asp Trp Tyr Leu Gly Asn Leu Trp Lys Asn His Arg Pro
         115                 120                 125            
 Trp Pro Ala Leu Gly Arg Gly Phe Asn Thr Gly Val Ile Leu Leu Arg
     130                 135                 140                
 Leu Asp Arg Leu Arg Gln Ala Gly Trp Glu Gln Met Trp Arg Leu Thr
 145                 150                 155                 160
 Ala Arg Arg Glu Leu Leu Ser Leu Pro Ala Thr Ser Leu Ala Asp Gln
                 165                 170                 175    
 Asp Ile Phe Asn Ala Val Ile Lys Glu His Pro Gly Leu Val Gln Arg
             180                 185                 190        
 Leu Pro Cys Val Trp Asn Val Gln Leu Ser Asp His Thr Leu Ala Glu
         195                 200                 205            
 Arg Cys Tyr Ser Glu Ala Ser Asp Leu Lys Val Ile His Trp Asn Ser
     210                 215                 220                
 Pro Lys Lys Leu Arg Val Lys Asn Lys His Val Glu Phe Phe Arg Asn
 225                 230                 235                 240
 Phe Tyr Leu Thr Phe Leu Glu Tyr Asp Gly Asn Leu Leu Arg Arg Glu
                 245                 250                 255    
 Leu Phe Val Cys Pro Ser Gln Pro Pro Pro Gly Ala Glu Gln Leu Gln
             260                 265                 270        
 Gln Ala Leu Ala Gln Leu Asp Glu Glu Asp Pro Cys Phe Glu Phe Arg
         275                 280                 285            
 Gln Gln Gln Leu Thr Val His Arg Val His Val Thr Phe Leu Pro His
     290                 295                 300                
 Glu Pro Pro Pro Pro Arg Pro His Asp Val Thr Leu Val Ala Gln Leu
 305                 310                 315                 320
 Ser Met Asp Arg Leu Gln Met Leu Glu Ala Leu Cys Arg His Trp Pro
                 325                 330                 335    
 Gly Pro Met Ser Leu Ala Leu Tyr Leu Thr Asp Ala Glu Ala Gln Gln
             340                 345                 350        
 Phe Leu His Phe Val Glu Ala Ser Pro Val Leu Ala Ala Arg Gln Asp
         355                 360                 365            
 Val Ala Tyr His Val Val Tyr Arg Glu Gly Pro Leu Tyr Pro Val Asn
     370                 375                 380                
 Gln Leu Arg Asn Val Ala Leu Ala Gln Ala Leu Thr Pro Tyr Val Phe
 385                 390                 395                 400
 Leu Ser Asp Ile Asp Phe Leu Pro Ala Tyr Ser Leu Tyr Asp Tyr Leu
                 405                 410                 415    
 Arg Ala Ser Ile Glu Gln Leu Gly Leu Gly Ser Arg Arg Lys Ala Ala
             420                 425                 430        
 Leu Val Val Pro Ala Phe Glu Thr Leu Arg Tyr Arg Phe Ser Phe Pro
         435                 440                 445            
 His Ser Lys Val Glu Leu Leu Ala Leu Leu Asp Ala Gly Thr Leu Tyr
     450                 455                 460                
 Thr Phe Arg Tyr His Glu Trp Pro Arg Gly His Ala Pro Thr Asp Tyr
 465                 470                 475                 480
 Ala Arg Trp Arg Glu Ala Gln Ala Pro Tyr Arg Val Gln Trp Ala Ala
                 485                 490                 495    
 Asn Tyr Glu Pro Tyr Val Val Val Pro Arg Asp Cys Pro Arg Tyr Asp
             500                 505                 510        
 Pro Arg Phe Val Gly Phe Gly Trp Asn Lys Val Ala His Ile Val Glu
         515                 520                 525            
 Leu Asp Ala Gln Glu Tyr Glu Leu Leu Val Leu Pro Glu Ala Phe Thr
     530                 535                 540                
 Ile His Leu Pro His Ala Pro Ser Leu Asp Ile Ser Arg Phe Arg Ser
 545                 550                 555                 560
 Ser Pro Thr Tyr Arg Asp Cys Leu Gln Ala Leu Lys Asp Glu Phe His
                 565                 570                 575    
 Gln Asp Leu Ser Arg His His Gly Ala Ala Ala Leu Lys Tyr Leu Pro
             580                 585                 590        
 Ala Leu Gln Gln Pro Gln Ser Pro Ala Arg Gly
         595                 600            



      <210> 770
      <211> 460
      <212> PRT
      <213> Homo sapiens


      <400> 770
 Met Asn Phe Ser Glu Val Phe Lys Leu Ser Ser Leu Leu Cys Lys Phe
   1               5                  10                  15    
 Ser Pro Asp Gly Lys Tyr Leu Ala Ser Cys Val Gln Tyr Arg Leu Val
              20                  25                  30        
 Val Arg Asp Val Asn Thr Leu Gln Ile Leu Gln Leu Tyr Thr Cys Leu
          35                  40                  45            
 Asp Gln Ile Gln His Ile Glu Trp Ser Ala Asp Ser Leu Phe Ile Leu
      50                  55                  60                
 Cys Ala Met Tyr Lys Arg Gly Leu Val Gln Val Trp Ser Leu Glu Gln
  65                  70                  75                  80
 Pro Glu Trp His Cys Lys Ile Asp Glu Gly Ser Ala Gly Leu Val Ala
                  85                  90                  95    
 Ser Cys Trp Ser Pro Asp Gly Arg His Ile Leu Asn Thr Thr Glu Phe
             100                 105                 110        
 His Leu Arg Ile Thr Val Trp Ser Leu Cys Thr Lys Ser Val Ser Tyr
         115                 120                 125            
 Ile Lys Tyr Pro Lys Ala Cys Pro Gln Gly Ile Thr Phe Thr Arg Asp
     130                 135                 140                
 Gly Arg Tyr Met Ala Leu Ala Glu Arg Arg Asp Cys Lys Asp Tyr Val
 145                 150                 155                 160
 Ser Ile Phe Val Cys Ser Asp Trp Gln Leu Leu Arg His Phe Asp Thr
                 165                 170                 175    
 Asp Thr Gln Asp Leu Thr Gly Ile Glu Trp Ala Pro Asn Gly Cys Val
             180                 185                 190        
 Leu Ala Val Trp Asp Thr Cys Leu Glu Tyr Lys Ile Leu Leu Tyr Ser
         195                 200                 205            
 Leu Asp Gly Arg Leu Leu Ser Thr Tyr Ser Ala Tyr Glu Trp Ser Leu
     210                 215                 220                
 Gly Ile Lys Ser Val Ala Trp Ser Pro Ser Ser Gln Phe Leu Ala Val
 225                 230                 235                 240
 Gly Ser Tyr Asp Gly Lys Val Arg Ile Leu Asn His Val Thr Trp Lys
                 245                 250                 255    
 Met Ile Thr Glu Phe Gly His Pro Ala Ala Ile Asn Asp Pro Lys Ile
             260                 265                 270        
 Val Val Tyr Lys Glu Ala Glu Lys Ser Pro Gln Leu Gly Leu Gly Cys
         275                 280                 285            
 Leu Ser Phe Pro Pro Pro Arg Ala Gly Ala Gly Pro Leu Pro Ser Ser
     290                 295                 300                
 Glu Ser Lys Tyr Glu Ile Ala Ser Val Pro Val Ser Leu Gln Thr Leu
 305                 310                 315                 320
 Lys Pro Val Thr Asp Arg Ala Asn Pro Lys Ile Gly Ile Gly Met Leu
                 325                 330                 335    
 Ala Phe Ser Pro Asp Ser Tyr Phe Leu Ala Thr Arg Asn Asp Asn Ile
             340                 345                 350        
 Pro Asn Ala Val Trp Val Trp Asp Ile Gln Lys Leu Arg Leu Phe Ala
         355                 360                 365            
 Val Leu Glu Gln Leu Ser Pro Val Arg Ala Phe Gln Trp Asp Pro Gln
     370                 375                 380                
 Gln Pro Arg Leu Ala Ile Cys Thr Gly Gly Ser Arg Leu Tyr Leu Trp
 385                 390                 395                 400
 Ser Pro Ala Gly Cys Met Ser Val Gln Val Pro Gly Glu Gly Asp Phe
                 405                 410                 415    
 Ala Val Leu Ser Leu Cys Trp His Leu Ser Gly Asp Ser Met Ala Leu
             420                 425                 430        
 Leu Ser Lys Asp His Phe Cys Leu Cys Phe Leu Glu Thr Glu Ala Val
         435                 440                 445            
 Val Gly Thr Ala Cys Arg Gln Leu Gly Gly His Thr
     450                 455                 460



      <210> 771
      <211> 616
      <212> PRT
      <213> Homo sapiens


      <400> 771
 Met Asp Asp Ser Asp Thr Pro Thr Tyr Tyr Leu Gln Ile Glu Pro Gln
   1               5                  10                  15    
 Asp Gly Cys His Pro Gly Asp Ser Val Glu Arg Ser Val Thr Cys Leu
              20                  25                  30        
 Pro Ser Ala Ser Asp Glu Asn Glu Asn Gln Leu Asp Gly Asp Gly His
          35                  40                  45            
 Glu His Leu Thr Ser Ser Asp Ser Ala Met Gly Lys Pro Gln Val Ser
      50                  55                  60                
 Glu Gln Asp Ser Leu Asn Asn Asn Glu Ser Cys Thr Leu Ser Cys Glu
  65                  70                  75                  80
 Val Ala Ala Gly Glu Asn Ser Gln Asn Thr Leu Cys Glu Ala Ser Arg
                  85                  90                  95    
 Asp Glu Gln Ala Phe Leu Gly Lys Asp Lys Lys Ile Pro Gly Lys Arg
             100                 105                 110        
 Ser Pro Arg Ser Lys Lys Gly Thr Ala Lys Lys Ile Pro Pro Gly Leu
         115                 120                 125            
 Phe Ser Gly Asp Ile Ala Pro Leu Met Gln Glu Lys Val Leu Ser Ala
     130                 135                 140                
 Val Thr Tyr Ala Val Asp Asp Glu Glu Ala Ala Glu Val Asn Ala Asn
 145                 150                 155                 160
 Glu Gln Pro Glu Ala Pro Lys Leu Val Leu Gln Ser Leu Phe Ser Leu
                 165                 170                 175    
 Ile Arg Gly Glu Val Glu Gln Leu Asp Ser Arg Ala Leu Pro Leu Cys
             180                 185                 190        
 Leu His Gln Ile Ala Glu Ser Tyr Phe Gln Glu Glu Asp Tyr Glu Lys
         195                 200                 205            
 Ala Met Lys Phe Ile Gln Leu Glu Arg Leu Tyr His Glu Gln Leu Leu
     210                 215                 220                
 Ala Asn Leu Ser Ala Ile Gln Glu Gln Trp Glu Thr Lys Trp Lys Thr
 225                 230                 235                 240
 Val Gln Pro His Thr Val Thr Ala Leu Arg Asn Ser Glu Lys Gly Phe
                 245                 250                 255    
 Asn Gly Glu Asp Phe Glu Arg Leu Thr Lys Ile Cys Ala Thr His Gln
             260                 265                 270        
 Asp Pro Leu Leu Ser Lys His Lys Ile Ala Ala Val Glu Lys Ser Gln
         275                 280                 285            
 Glu Arg Lys Cys Ser Thr Gln Leu Leu Val Ser Glu Asp Pro Lys Glu
     290                 295                 300                
 Gly Gly Ala Thr Thr Lys Glu Ser Glu Ser Lys Thr Cys Leu Gly Thr
 305                 310                 315                 320
 Glu Ser Ser Lys Glu Ser Gln His Thr Val Glu Pro Leu Gly Ser Ser
                 325                 330                 335    
 Pro Cys Cys His Gln Met Asp Val Gln Thr Asp Ser Pro Ser Leu Ser
             340                 345                 350        
 Val Thr Ala Gly Lys Asp His Met Glu Glu Leu Leu Cys Ser Ala Glu
         355                 360                 365            
 Ala Thr Leu Ala Leu His Thr Gln Ser Ser Glu Thr Ala Gly Ser Pro
     370                 375                 380                
 Ser Gly Pro Asp Ser Ser Glu Asp Ala Cys Glu Asp Asp Ser Arg Leu
 385                 390                 395                 400
 Gln Leu Ala Gln Thr Glu Ala Cys Gln Asp Val Ala Arg Ile Glu Gly
                 405                 410                 415    
 Ile Ala Glu Asp Pro Lys Val Phe Leu Ser Ser Lys Ser Lys Thr Glu
             420                 425                 430        
 Pro Leu Ile Ser Pro Gly Cys Asp Arg Ile Pro Pro Ala Leu Ile Ser
         435                 440                 445            
 Glu Gly Lys Tyr Ser Gln Ala Gln Arg Lys Glu Leu Arg Leu Pro Leu
     450                 455                 460                
 Arg Asp Ala Ser Glu Ala Leu Pro Thr Asp Gln Leu Glu Asn Asn Glu
 465                 470                 475                 480
 Leu Asn Glu Leu Gln Gln Pro Asp Leu Thr Asp Ser Asp Gly Lys Ser
                 485                 490                 495    
 Pro Gln Ala Gln Ala Asp Ser Asp Gly Ser Glu Asn Val Leu Cys Gly
             500                 505                 510        
 Asn Asn Gln Ile Ser Asp Leu Gly Ile Leu Leu Pro Glu Val Cys Met
         515                 520                 525            
 Ala Pro Glu Glu Lys Gly Asp Lys Asp Asp Gln Leu Asn Lys Glu Thr
     530                 535                 540                
 Glu Asp Tyr Leu Asn Ser Leu Leu Glu Gly Cys Leu Lys Asp Thr Glu
 545                 550                 555                 560
 Asp Ser Leu Ser Tyr Glu Asp Asn Gln Asp Asp Asp Ser Asp Leu Leu
                 565                 570                 575    
 Gln Asp Leu Ser Pro Glu Glu Ala Ser Tyr Ser Leu Gln Glu Asn Leu
             580                 585                 590        
 Pro Ser Asp Glu Ser Cys Leu Ser Leu Asp Asp Leu Ala Lys Arg Ile
         595                 600                 605            
 Glu Ile Ala Glu Val Asn Gln Arg
     610                 615    



      <210> 772
      <211> 366
      <212> PRT
      <213> Homo sapiens


      <400> 772
 Met Leu Pro Ser Leu Gln Glu Ser Met Asp Gly Asp Glu Lys Glu Leu
   1               5                  10                  15    
 Glu Ser Ser Glu Glu Gly Gly Ser Ala Glu Glu Arg Arg Leu Glu Pro
              20                  25                  30        
 Pro Ser Ser Ser His Tyr Cys Leu Tyr Ser Tyr Arg Gly Ser Arg Leu
          35                  40                  45            
 Ala Gln Gln Arg Gly Asp Ser Glu Asp Gly Ser Pro Ser Gly Thr Asn
      50                  55                  60                
 Ala Glu Thr Pro Ser Gly Asp Asp Phe Ser Leu Ser Leu Ala Asp Thr
  65                  70                  75                  80
 Asn Leu Pro Ser Glu Val Glu Pro Glu Leu Arg Ser Phe Ile Ala Lys
                  85                  90                  95    
 Arg Leu Ser Arg Gly Ala Val Phe Glu Gly Leu Gly Asn Val Ala Ser
             100                 105                 110        
 Val Glu Leu Lys Ile Pro Gly Tyr Arg Val Gly Cys Tyr Tyr Cys Leu
         115                 120                 125            
 Phe Gln Asn Glu Lys Leu Leu Pro Glu Thr Val Thr Ile Asp Ser Glu
     130                 135                 140                
 Arg Asn Pro Ser Glu Tyr Val Val Cys Phe Leu Gly Gly Ser Glu Lys
 145                 150                 155                 160
 Gly Leu Glu Leu Phe Arg Leu Glu Leu Asp Lys Tyr Ile Gln Gly Leu
                 165                 170                 175    
 Lys Asn Asn Met Asn Cys Glu Ala Arg Gly Leu Glu Ser His Ile Lys
             180                 185                 190        
 Ser Tyr Leu Ser Ser Trp Phe Glu Asp Val Val Cys Pro Ile Gln Arg
         195                 200                 205            
 Val Val Leu Leu Phe Gln Glu Lys Leu Thr Phe Leu Leu His Ala Ala
     210                 215                 220                
 Leu Ser Tyr Thr Pro Val Glu Val Lys Glu Ser Asp Glu Lys Thr Lys
 225                 230                 235                 240
 Arg Asp Ile Asn Arg Phe Leu Ser Val Ala Ser Leu Gln Gly Leu Ile
                 245                 250                 255    
 His Glu Gly Thr Met Thr Ser Leu Cys Met Ala Met Thr Glu Glu Gln
             260                 265                 270        
 His Lys Ser Val Val Ile Asp Cys Ser Ser Ser Gln Pro Gln Phe Cys
         275                 280                 285            
 Asn Ala Gly Ser Asn Arg Phe Cys Glu Asp Trp Met Gln Ala Phe Leu
     290                 295                 300                
 Asn Gly Ala Lys Gly Gly Asn Pro Phe Leu Phe Arg Gln Val Leu Glu
 305                 310                 315                 320
 Asn Phe Lys Leu Lys Ala Ile Gln Asp Thr Asn Asn Leu Lys Arg Phe
                 325                 330                 335    
 Ile Arg Gln Ala Glu Met Asn His Tyr Ala Leu Phe Lys Cys Tyr Met
             340                 345                 350        
 Phe Leu Lys Asn Cys Gly Ser Gly Asp Thr Phe Glu Asp Cys
         355                 360                 365    



      <210> 773
      <211> 445
      <212> PRT
      <213> Homo sapiens


      <400> 773
 Met Thr Glu Leu Arg Gln Arg Val Ala His Glu Pro Val Ala Pro Pro
   1               5                  10                  15    
 Glu Asp Lys Glu Ser Glu Ser Glu Ala Lys Val Asp Gly Glu Thr Ala
              20                  25                  30        
 Ser Asp Ser Glu Ser Arg Ala Glu Ser Ala Pro Leu Pro Val Ser Ala
          35                  40                  45            
 Asp Asp Thr Pro Glu Val Leu Asn Arg Ala Leu Ser Asn Leu Ser Ser
      50                  55                  60                
 Arg Trp Lys Asn Trp Trp Val Arg Gly Ile Leu Thr Leu Ala Met Ile
  65                  70                  75                  80
 Ala Phe Phe Phe Ile Ile Ile Tyr Leu Gly Pro Met Val Leu Met Ile
                  85                  90                  95    
 Ile Val Met Cys Val Gln Ile Lys Cys Phe His Glu Ile Ile Thr Ile
             100                 105                 110        
 Gly Tyr Asn Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr Leu
         115                 120                 125            
 Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu Thr
     130                 135                 140                
 Val Thr Asp Tyr Phe Phe Thr Leu Val Gln Arg Glu Glu Pro Leu Arg
 145                 150                 155                 160
 Ile Leu Ser Lys Tyr His Arg Phe Ile Ser Phe Thr Leu Tyr Leu Ile
                 165                 170                 175    
 Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg Leu
             180                 185                 190        
 Gln Phe Tyr Met Phe Gly Trp Thr His Val Thr Leu Leu Ile Val Val
         195                 200                 205            
 Thr Gln Ser His Leu Val Ile His Asn Leu Phe Glu Gly Met Ile Trp
     210                 215                 220                
 Phe Ile Val Pro Ile Ser Cys Val Ile Cys Asn Asp Ile Met Ala Tyr
 225                 230                 235                 240
 Met Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser Pro
                 245                 250                 255    
 Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ala Thr Val Val
             260                 265                 270        
 Phe Gly Leu Leu Leu Ser Tyr Val Met Ser Gly Tyr Arg Cys Phe Val
         275                 280                 285            
 Cys Pro Val Glu Tyr Asn Asn Asp Thr Asn Ser Phe Thr Val Asp Cys
     290                 295                 300                
 Glu Pro Ser Asp Leu Phe Arg Leu Gln Glu Tyr Asn Ile Pro Gly Val
 305                 310                 315                 320
 Ile Gln Ser Val Ile Gly Trp Lys Thr Val Arg Met Tyr Pro Phe Gln
                 325                 330                 335    
 Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro Phe
             340                 345                 350        
 Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys Asp
         355                 360                 365            
 Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe Asp
     370                 375                 380                
 Cys Gln Tyr Leu Met Ala Thr Phe Val Asn Val Tyr Ile Ala Ser Phe
 385                 390                 395                 400
 Ile Arg Gly Pro Asn Pro Ser Lys Leu Ile Gln Gln Phe Leu Thr Leu
                 405                 410                 415    
 Arg Pro Asp Gln Gln Leu His Ile Phe Asn Thr Leu Arg Ser His Leu
             420                 425                 430        
 Ile Asp Lys Gly Met Leu Thr Ser Thr Thr Glu Asp Glu
         435                 440                 445



      <210> 774
      <211> 429
      <212> PRT
      <213> Homo sapiens


      <400> 774
 Met Val Thr Arg Pro Pro Pro Gln Ala Arg Leu Ala Ala Leu Lys Arg
   1               5                  10                  15    
 Pro Asp Asp Val Pro Leu Ser Leu Ser Pro Ser Lys Arg Ala Cys Ala
              20                  25                  30        
 Ser Pro Ser Ala Gln Val Glu Gly Ser Pro Val Ala Gly Ser Asp Gly
          35                  40                  45            
 Ser Gln Pro Ala Val Lys Leu Glu Pro Leu His Phe Leu Gln Cys His
      50                  55                  60                
 Ser Lys Asn Asn Ser Pro Gln Asp Leu Glu Thr Gln Leu Trp Ala Cys
  65                  70                  75                  80
 Ala Phe Glu Pro Ala Trp Glu Glu Gly Ala Thr Ser Gln Thr Val Ala
                  85                  90                  95    
 Thr Cys Gly Gly Glu Ala Val Cys Val Ile Asp Cys Gln Thr Gly Ile
             100                 105                 110        
 Val Leu His Lys Tyr Lys Ala Pro Gly Glu Glu Phe Phe Ser Val Ala
         115                 120                 125            
 Trp Thr Ala Leu Met Val Val Thr Gln Ala Gly His Lys Lys Arg Trp
     130                 135                 140                
 Ser Val Leu Ala Ala Ala Gly Leu Arg Gly Leu Val Arg Leu Leu His
 145                 150                 155                 160
 Val Arg Ala Gly Phe Cys Cys Gly Val Ile Arg Ala His Lys Lys Ala
                 165                 170                 175    
 Ile Ala Thr Leu Cys Phe Ser Pro Ala His Glu Thr His Leu Phe Thr
             180                 185                 190        
 Ala Ser Tyr Asp Lys Arg Ile Ile Leu Trp Asp Ile Gly Val Pro Asn
         195                 200                 205            
 Gln Asp Tyr Glu Phe Gln Ala Ser Gln Leu Leu Thr Leu Asp Thr Thr
     210                 215                 220                
 Ser Ile Pro Leu Arg Leu Cys Pro Val Ala Ser Cys Pro Asp Ala Arg
 225                 230                 235                 240
 Leu Leu Ala Gly Cys Glu Gly Gly Cys Cys Cys Trp Asp Val Arg Leu
                 245                 250                 255    
 Asp Gln Pro Gln Lys Arg Arg Val Cys Glu Val Glu Phe Val Phe Ser
             260                 265                 270        
 Glu Gly Ser Glu Ala Ser Gly Arg Arg Val Asp Gly Leu Ala Phe Val
         275                 280                 285            
 Asn Glu Asp Ile Val Ala Ser Lys Gly Ser Gly Leu Gly Thr Ile Cys
     290                 295                 300                
 Leu Trp Ser Trp Arg Gln Thr Trp Gly Gly Arg Gly Ser Gln Ser Thr
 305                 310                 315                 320
 Val Ala Val Val Val Leu Ala Arg Leu Gln Trp Ser Ser Thr Glu Leu
                 325                 330                 335    
 Ala Tyr Phe Ser Leu Ser Ala Cys Pro Asp Lys Gly Ile Val Leu Cys
             340                 345                 350        
 Gly Asp Glu Glu Gly Asn Val Trp Leu Tyr Asp Val Ser Asn Ile Leu
         355                 360                 365            
 Lys Gln Pro Pro Leu Leu Pro Ala Ala Leu Gln Ala Pro Thr Gln Ile
     370                 375                 380                
 Leu Lys Trp Pro Gln Pro Trp Ala Leu Gly Gln Val Val Thr Lys Thr
 385                 390                 395                 400
 Met Val Asn Thr Val Val Ala Asn Ala Ser Phe Thr Tyr Leu Thr Ala
                 405                 410                 415    
 Leu Thr Asp Ser Asn Ile Val Ala Ile Trp Gly Arg Met
             420                 425                



      <210> 775
      <211> 555
      <212> PRT
      <213> Homo sapiens


      <400> 775
 Met Asp Val Ser Ser Glu His Thr Lys Asp Pro Gly Gly Glu Gly Gly
   1               5                  10                  15    
 Asp Gly Glu Ser Leu Ala Ala Arg Pro Ser Lys Ile Lys Ala Ser Ser
              20                  25                  30        
 Gly Pro Pro Thr Ser Pro Glu Pro Gly Glu Leu Glu Ser Glu Pro Glu
          35                  40                  45            
 Glu Glu Glu Glu Glu Gln Ala Ala Ser Gln Gly Gly Thr Ala Ala Asp
      50                  55                  60                
 Glu Gln Ala Glu Ala Pro Lys Gly Leu Thr Ala Ala Glu Ala Ala Gly
  65                  70                  75                  80
 Glu Glu Gly Pro Gly Glu Pro Gly Arg Pro Ala Glu Pro Gln Pro Glu
                  85                  90                  95    
 Pro Glu Glu Pro Ala Glu Val Gly Ala Glu Glu Pro Ala Gln Pro Glu
             100                 105                 110        
 Pro Gly Ala Gly Pro Glu Glu Leu Glu Ala Glu Ala Gly Ala Glu Glu
         115                 120                 125            
 Leu Glu Gln Ala Ala Glu Gly Lys Glu Val Arg Phe Gln Ala Ser Leu
     130                 135                 140                
 Pro Leu Thr Arg Ile Asp Glu Glu Glu Ala Ala Ala Ala Pro Glu Ala
 145                 150                 155                 160
 Glu Thr Glu Arg Val Glu Gly Glu Glu Glu Asp Lys Glu Glu Thr Gln
                 165                 170                 175    
 Arg Asp Gly Ala Glu Ser Lys Glu Arg Asp Gly Glu Gly Arg Pro Ala
             180                 185                 190        
 Lys Ser Gln Glu Glu Gly Lys Arg Leu Tyr Gly Arg Asp Glu Phe Glu
         195                 200                 205            
 Asp Leu Glu Trp Ser Glu Glu Val Gln Lys Leu Gln Glu Gln Gln Leu
     210                 215                 220                
 Arg Ser Asp Leu Leu Asp Gln Tyr Arg Ser Leu Leu Val Glu Arg Asn
 225                 230                 235                 240
 Arg Ser Gln Arg Tyr Asn Leu Tyr Leu Gln His Lys Ile Phe Glu Ala
                 245                 250                 255    
 Leu Arg Arg Lys Lys Gly Leu Glu Ala Ala Glu Val Ala Asp Arg Gly
             260                 265                 270        
 Ala Glu Ala Glu Ala Pro Glu Lys Glu Gln Ala Tyr Leu Arg His Leu
         275                 280                 285            
 Gly Met Leu Glu Glu Leu Lys Lys Gln Gln Ala Asp Asp Leu Gln Trp
     290                 295                 300                
 Tyr His Gln Glu Leu Gly Gln Leu Lys Arg Gln Cys Gln Glu Lys Leu
 305                 310                 315                 320
 Thr Arg Val Glu Lys Glu Trp Arg Arg Phe Gln Ala Leu Lys Lys Gln
                 325                 330                 335    
 Val Val Met Gln Ala Met Gly Ser Cys Arg Met Arg Gly Gly Arg Gln
             340                 345                 350        
 Ala Ala Leu Arg Glu Val Glu Gln Ile Gln Ala Leu Glu Asp Lys Lys
         355                 360                 365            
 Glu Lys Glu Met Ser Ala Val Arg Leu Glu Asn Ile Gln Leu Lys Gln
     370                 375                 380                
 Ser Leu Val His Phe Glu Thr Arg Met Arg Thr Gln Glu Asp Leu Thr
 385                 390                 395                 400
 Gln Gly Leu Leu Leu Ile Asp Phe Glu Gln Leu Lys Ile Glu Asn Gln
                 405                 410                 415    
 Thr Phe Asn Glu Lys Ile Glu Glu Arg Asn Glu Glu Leu Leu Lys Leu
             420                 425                 430        
 Arg Ser Lys Val Thr Asn Ser Val Gln Val Ile Thr His Val Lys Glu
         435                 440                 445            
 Lys Leu His Phe Met Asp Met Glu Asn Ala Cys Lys Lys Thr Gln Leu
     450                 455                 460                
 Ala Glu Ile Glu Ala Gln Ala Ala Leu Gly Arg Asp Ile Leu Thr Lys
 465                 470                 475                 480
 Thr Lys Gln Ala Arg Glu Gly Leu Arg Thr Asp Asn Ile Arg Leu Asn
                 485                 490                 495    
 Gln Lys Cys Gly Leu Leu Gly Lys Asp Ser Leu Leu Arg Asp Leu Glu
             500                 505                 510        
 Glu Lys Val Asp Lys Thr Glu Leu Leu His Arg Arg Leu Glu Ser Leu
         515                 520                 525            
 Lys Arg His His Ala Ser Leu Thr Leu Ser Cys Arg Gly Val Arg Gln
     530                 535                 540                
 Lys Ile Arg Glu Ala Lys Ala Phe Leu Pro Ser
 545                 550                 555



      <210> 776
      <211> 523
      <212> PRT
      <213> Homo sapiens


      <400> 776
 Met Ala Gly Val Ser Tyr Ala Ala Pro Trp Trp Val Ser Leu Leu His
   1               5                  10                  15    
 Arg Leu Pro His Phe Asp Leu Ser Trp Glu Ala Thr Ser Ser Gln Phe
              20                  25                  30        
 Arg Pro Glu Asp Thr Asp Tyr Gln Gln Ala Leu Leu Leu Leu Gly Ala
          35                  40                  45            
 Ala Ala Leu Ala Cys Leu Ala Leu Asp Leu Leu Phe Leu Leu Phe Tyr
      50                  55                  60                
 Ser Phe Trp Leu Cys Cys Arg Arg Arg Lys Ser Glu Glu His Leu Asp
  65                  70                  75                  80
 Ala Asp Cys Cys Cys Thr Ala Trp Cys Val Ile Ile Ala Thr Leu Val
                  85                  90                  95    
 Cys Ser Ala Gly Ile Ala Val Gly Phe Tyr Gly Asn Gly Glu Thr Ser
             100                 105                 110        
 Asp Gly Ile His Arg Ala Thr Tyr Ser Leu Arg His Ala Asn Arg Thr
         115                 120                 125            
 Val Ala Gly Val Gln Asp Arg Val Trp Asp Thr Ala Val Gly Leu Asn
     130                 135                 140                
 His Thr Ala Glu Pro Ser Leu Gln Thr Leu Glu Arg Gln Leu Ala Gly
 145                 150                 155                 160
 Arg Pro Glu Pro Leu Arg Ala Val Gln Arg Leu Gln Gly Leu Leu Glu
                 165                 170                 175    
 Thr Leu Leu Gly Tyr Thr Ala Ala Ile Pro Phe Trp Arg Asn Thr Ala
             180                 185                 190        
 Val Ser Leu Glu Val Leu Ala Glu Gln Val Asp Leu Tyr Asp Trp Tyr
         195                 200                 205            
 Arg Trp Leu Gly Tyr Leu Gly Leu Leu Leu Leu Asp Val Ile Ile Cys
     210                 215                 220                
 Leu Leu Val Leu Val Gly Leu Ile Arg Ser Ser Lys Gly Ile Leu Val
 225                 230                 235                 240
 Gly Val Cys Leu Leu Gly Val Leu Ala Leu Val Ile Ser Trp Gly Ala
                 245                 250                 255    
 Leu Gly Leu Glu Leu Ala Val Ser Val Gly Ser Ser Asp Phe Cys Val
             260                 265                 270        
 Asp Pro Asp Ala Tyr Val Thr Lys Met Val Glu Glu Tyr Ser Val Leu
         275                 280                 285            
 Ser Gly Asp Ile Leu Gln Tyr Tyr Leu Ala Cys Ser Pro Arg Ala Ala
     290                 295                 300                
 Asn Pro Phe Gln Gln Lys Leu Ser Gly Ser His Lys Ala Leu Val Glu
 305                 310                 315                 320
 Met Gln Asp Val Val Ala Glu Leu Leu Arg Thr Val Pro Trp Glu Gln
                 325                 330                 335    
 Pro Ala Thr Lys Asp Pro Leu Leu Arg Val Gln Glu Val Leu Asn Gly
             340                 345                 350        
 Thr Glu Val Asn Leu Gln His Leu Thr Ala Leu Val Asp Cys Arg Ser
         355                 360                 365            
 Leu His Leu Asp Tyr Val Gln Ala Leu Thr Gly Phe Cys Tyr Asp Gly
     370                 375                 380                
 Val Glu Gly Leu Ile Tyr Leu Ala Leu Phe Ser Phe Val Thr Ala Leu
 385                 390                 395                 400
 Met Phe Ser Ser Ile Val Cys Ser Val Pro His Thr Trp Gln Gln Lys
                 405                 410                 415    
 Arg Gly Pro Asp Glu Asp Gly Glu Glu Glu Ala Ala Pro Gly Pro Arg
             420                 425                 430        
 Gln Ala His Asp Ser Leu Tyr Arg Val His Met Pro Ser Leu Tyr Ser
         435                 440                 445            
 Cys Gly Ser Ser Tyr Gly Ser Glu Thr Ser Ile Pro Ala Ala Ala His
     450                 455                 460                
 Thr Val Ser Asn Ala Pro Val Thr Glu Tyr Met Ser Gln Asn Ala Asn
 465                 470                 475                 480
 Phe Gln Asn Pro Arg Cys Glu Asn Thr Pro Leu Ile Gly Arg Glu Ser
                 485                 490                 495    
 Pro Pro Pro Ser Tyr Thr Ser Ser Met Arg Ala Lys Tyr Leu Ala Thr
             500                 505                 510        
 Ser Gln Pro Arg Pro Asp Ser Ser Gly Ser His
         515                 520            



      <210> 777
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 777
 Met Tyr Thr Tyr Gly Asn Lys Gln His Asn Ser Pro Thr Trp Asp Asp
   1               5                  10                  15    
 Pro Thr Leu Ala Ile Ala Leu Ala Ala Asn Ala Trp Ala Phe Val Leu
              20                  25                  30        
 Phe Tyr Val Ile Pro Glu Val Ser Gln Val Thr Lys Ser Ile Pro Lys
          35                  40                  45            
 Gln Ser Tyr Gln Gly Asp Met Tyr Pro Thr Arg Gly Val Gly Tyr Glu
      50                  55                  60                
 Thr Ile Leu Lys Glu Gln Lys Gly Gln Ser Met Phe Val Glu Asn Lys
  65                  70                  75                  80
 Ala Phe Ser Met Asp Glu Pro Val Ala Ala Lys Arg Pro Val Ser Pro
                  85                  90                  95    
 Tyr Ser Gly Tyr Asn Gly Gln Leu Leu Thr Ser Val Tyr Gln Pro Thr
             100                 105                 110        
 Glu Met Ala Leu Met His Lys Val Pro Ser Glu Gly Ala Tyr Asp Ile
         115                 120                 125            
 Ile Leu Pro Arg Ala Thr Ala Asn Ser Gln Val Met Gly Ser Ala Asn
     130                 135                 140                
 Ser Thr Leu Arg Ala Glu Asp Met Tyr Ser Ala Gln Ser His Gln Ala
 145                 150                 155                 160
 Ala Thr Pro Pro Lys Asp Gly Lys Asn Ser Gln Val Phe Arg Asn Pro
                 165                 170                 175    
 Tyr Val Trp Asp
             180



      <210> 778
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 778
 Met Ala Ser Pro Ala Ala Ser Ser Val Arg Pro Pro Arg Pro Lys Lys
   1               5                  10                  15    
 Glu Pro Gln Thr Leu Val Ile Pro Lys Asn Ala Ala Glu Glu Gln Lys
              20                  25                  30        
 Leu Lys Leu Glu Arg Leu Met Lys Asn Pro Asp Lys Ala Val Pro Ile
          35                  40                  45            
 Pro Glu Lys Met Ser Glu Trp Ala Pro Arg Pro Pro Pro Glu Phe Val
      50                  55                  60                
 Arg Asp Val Met Gly Ser Ser Ala Gly Ala Gly Ser Gly Glu Phe His
  65                  70                  75                  80
 Val Tyr Arg His Leu Arg Arg Arg Glu Tyr Gln Arg Gln Asp Tyr Met
                  85                  90                  95    
 Asp Ala Met Ala Glu Lys Gln Lys Leu Asp Ala Glu Phe Gln Lys Arg
             100                 105                 110        
 Leu Glu Lys Asn Lys Ile Ala Ala Glu Glu Gln Thr Ala Lys Arg Arg
         115                 120                 125            
 Lys Lys Arg Gln Lys Leu Lys Glu Lys Lys Leu Leu Ala Lys Lys Met
     130                 135                 140                
 Lys Leu Glu Gln Lys Lys Gln Glu Gly Pro Gly Gln Pro Lys Glu Gln
 145                 150                 155                 160
 Gly Ser Ser Ser Ser Ala Glu Ala Ser Gly Thr Glu Glu Glu Glu Glu
                 165                 170                 175    
 Val Pro Ser Phe Thr Met Gly Arg
             180                



      <210> 779
      <211> 154
      <212> PRT
      <213> Homo sapiens


      <400> 779
 Met Ala Ala Ala Trp Gly Ser Ser Leu Thr Ala Ala Thr Gln Arg Ala
   1               5                  10                  15    
 Val Thr Pro Trp Pro Arg Gly Arg Leu Leu Thr Ala Ser Leu Gly Pro
              20                  25                  30        
 Gln Ala Arg Arg Glu Ala Ser Ser Ser Ser Pro Glu Ala Gly Glu Gly
          35                  40                  45            
 Gln Ile Arg Leu Thr Asp Ser Cys Val Gln Arg Leu Leu Glu Ile Thr
      50                  55                  60                
 Glu Gly Ser Glu Phe Leu Arg Leu Gln Val Glu Gly Gly Gly Cys Ser
  65                  70                  75                  80
 Gly Phe Gln Tyr Lys Phe Ser Leu Asp Thr Val Ile Asn Pro Asp Asp
                  85                  90                  95    
 Arg Val Phe Glu Gln Gly Gly Ala Arg Val Val Val Asp Ser Asp Ser
             100                 105                 110        
 Leu Ala Phe Val Lys Gly Ala Gln Val Asp Phe Ser Gln Glu Leu Ile
         115                 120                 125            
 Arg Ser Ser Phe Gln Val Leu Asn Asn Pro Gln Ala Gln Gln Gly Cys
     130                 135                 140                
 Ser Cys Gly Ser Ser Phe Ser Ile Lys Leu
 145                 150                



      <210> 780
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 780
 Met Trp Phe Phe Lys Gln Lys Glu Lys Glu Asp Gln Val Leu Ser Tyr
   1               5                  10                  15    
 Ile Asn Gly Val Thr Thr Ser Lys Pro Gly Val Ser Leu Val Tyr Ser
              20                  25                  30        
 Met Pro Ser Arg Asn Leu Ser Leu Arg Leu Glu Gly Leu Gln Glu Lys
          35                  40                  45            
 Asp Ser Gly Pro Tyr Ser Cys Ser Val Asn Val Gln Asp Lys Gln Gly
      50                  55                  60                
 Lys Ser Arg Gly His Ser Ile Lys Thr Leu Glu Leu Asn Val Leu Val
  65                  70                  75                  80
 Pro Pro Ala Pro Pro Ser Cys Arg Leu Gln Gly Val Pro His Val Gly
                  85                  90                  95    
 Ala Asn Val Thr Leu Ser Cys Gln Ser Pro Arg Ser Lys Pro Ala Val
             100                 105                 110        
 Gln Tyr Gln Trp Asp Arg Gln Leu Pro Ser Phe Gln Thr Phe Phe Ala
         115                 120                 125            
 Pro Ala Leu Asp Val Ile Arg Gly Ser Leu Ser Leu Thr Asn Leu Ser
     130                 135                 140                
 Ser Ser Met Ala Gly Val Tyr Val Cys Lys Ala His Asn Glu Val Gly
 145                 150                 155                 160
 Thr Ala Gln Cys Asn Val Thr Leu Glu Val Ser Thr Gly Gln
                 165                 170                



      <210> 781
      <211> 195
      <212> PRT
      <213> Homo sapiens


      <400> 781
 Met Ala Pro Ala Ala Ser Arg Leu Arg Ala Glu Ala Gly Leu Gly Ala
   1               5                  10                  15    
 Leu Pro Arg Arg Ala Leu Ala Gln Tyr Leu Leu Phe Leu Arg Leu Tyr
              20                  25                  30        
 Pro Val Leu Thr Lys Ala Ala Thr Ser Gly Ile Leu Ser Ala Leu Gly
          35                  40                  45            
 Asn Phe Leu Ala Gln Met Ile Glu Lys Lys Arg Lys Lys Glu Asn Ser
      50                  55                  60                
 Arg Ser Leu Asp Val Gly Gly Pro Leu Arg Tyr Ala Val Tyr Gly Phe
  65                  70                  75                  80
 Phe Phe Thr Gly Pro Leu Ser His Phe Phe Tyr Phe Phe Met Glu His
                  85                  90                  95    
 Trp Ile Pro Pro Glu Val Pro Leu Ala Gly Leu Arg Arg Leu Leu Leu
             100                 105                 110        
 Asp Arg Leu Val Phe Ala Pro Ala Phe Leu Met Leu Phe Phe Leu Ile
         115                 120                 125            
 Met Asn Phe Leu Glu Gly Lys Asp Ala Ser Ala Phe Ala Ala Lys Met
     130                 135                 140                
 Arg Gly Gly Phe Trp Pro Ala Leu Arg Met Asn Trp Arg Val Trp Thr
 145                 150                 155                 160
 Pro Leu Gln Phe Ile Asn Ile Asn Tyr Val Pro Leu Lys Phe Arg Val
                 165                 170                 175    
 Leu Phe Ala Asn Leu Ala Ala Leu Phe Trp Tyr Ala Tyr Leu Ala Ser
             180                 185                 190        
 Leu Gly Lys
         195



      <210> 782
      <211> 250
      <212> PRT
      <213> Homo sapiens


      <400> 782
 Met Ser Ser Val Glu Asn Gly Gly His Trp Lys Arg Val Ala Arg Arg
   1               5                  10                  15    
 Gly Asn Ala Arg Ala Ser Gly Gly Gly Gln Pro Gly Val Gly Ser Ala
              20                  25                  30        
 Arg Val Ser Cys Leu Ser Phe Met Leu Gly Arg Arg Cys Cys Val His
          35                  40                  45            
 Val Arg Lys His Leu Ile Ala Cys Gln Lys Phe Pro Pro Leu Cys Ala
      50                  55                  60                
 Cys Gln Val Phe Asp Gln Val Arg Thr Leu Val Leu Cys Glu Cys Ala
  65                  70                  75                  80
 His Ala Asp Arg Ser Gly Gly Ala Pro Ser Leu Cys Pro His Ala Ala
                  85                  90                  95    
 Glu Pro Arg Gly Ser Pro Ala Pro Gln Ala Cys Gly Ser Ala Ala Lys
             100                 105                 110        
 Cys Val Arg Cys Ala Ser Trp Val Leu Leu Cys Ala Leu Ser Tyr Gly
         115                 120                 125            
 Asp Thr Gly Gly Val Gly Leu Asp Arg Tyr Arg Ser Asp Tyr Gly Asp
     130                 135                 140                
 Thr Gly Gly Val Arg Leu Asp Arg Tyr Arg Ser Asp Tyr Gly Gly Thr
 145                 150                 155                 160
 Gly Gly Val Gly Leu Asp Arg Tyr Arg Ser Asp Tyr Gly Gly Thr Gly
                 165                 170                 175    
 Gly Val Gly Leu Asp Arg Tyr Arg Ser Asp Tyr Gly Gly Thr Gly Gly
             180                 185                 190        
 Val Gly Leu Asp Arg Tyr Arg Ser Asp Tyr Gly Asp Thr Gly Gly Val
         195                 200                 205            
 Gly Leu Asp Arg Tyr Arg Ser Asp Tyr Gly Gly Thr Gly Cys Val Gly
     210                 215                 220                
 Leu Asp Arg Tyr Arg Ser Asp Tyr Gly Gly Thr Gly Gly Val Gly Leu
 225                 230                 235                 240
 Asp Arg Tyr Trp Ser Asp Ala Arg Ala Pro
                 245                 250



      <210> 783
      <211> 593
      <212> PRT
      <213> Homo sapiens


      <400> 783
 Met Gly Pro Thr Gly Pro Arg Gly Pro Val Gly Ile Gly Val Gln Gly
   1               5                  10                  15    
 Pro Lys Gly Asp Glu Gly Lys Lys Gly Ser Lys Gly Asn Gln Gly Gln
              20                  25                  30        
 Arg Gly Leu Pro Gly Pro Glu Gly Pro Lys Gly Glu Pro Gly Ile Met
          35                  40                  45            
 Gly Pro Phe Gly Met Pro Gly Thr Ser Ile Pro Gly Pro Pro Gly Pro
      50                  55                  60                
 Lys Gly Asp Arg Gly Gly Pro Gly Ile Pro Gly Phe Lys Gly Glu Pro
  65                  70                  75                  80
 Gly Leu Ser Ile Arg Gly Pro Lys Gly Val Gln Gly Pro Arg Gly Pro
                  85                  90                  95    
 Val Gly Ala Pro Gly Leu Lys Gly Asp Gly Tyr Pro Gly Val Pro Gly
             100                 105                 110        
 Pro Arg Gly Leu Pro Gly Pro Pro Gly Pro Met Gly Leu Arg Gly Val
         115                 120                 125            
 Gly Asp Thr Gly Ala Lys Gly Glu Pro Gly Val Arg Gly Pro Pro Gly
     130                 135                 140                
 Pro Ser Gly Pro Arg Gly Val Gly Thr Gln Gly Pro Lys Gly Asp Thr
 145                 150                 155                 160
 Gly Gln Lys Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Tyr Gly Ser
                 165                 170                 175    
 Gln Gly Ile Lys Gly Glu Gln Gly Pro Gln Gly Phe Pro Gly Pro Lys
             180                 185                 190        
 Gly Thr Met Gly His Gly Leu Pro Gly Gln Lys Gly Glu His Gly Glu
         195                 200                 205            
 Arg Gly Asp Val Gly Lys Lys Gly Asp Lys Gly Glu Ile Gly Glu Pro
     210                 215                 220                
 Gly Ser Pro Gly Lys Gln Gly Leu Gln Gly Pro Lys Gly Asp Leu Gly
 225                 230                 235                 240
 Leu Thr Lys Glu Glu Ile Ile Lys Leu Ile Thr Glu Ile Cys Gly Cys
                 245                 250                 255    
 Gly Pro Lys Cys Lys Glu Thr Pro Leu Glu Leu Val Phe Val Ile Asp
             260                 265                 270        
 Ser Ser Glu Ser Val Gly Pro Glu Asn Phe Gln Ile Ile Lys Asn Phe
         275                 280                 285            
 Val Lys Thr Met Ala Asp Arg Val Ala Leu Asp Leu Ala Thr Ala Arg
     290                 295                 300                
 Ile Gly Ile Ile Asn Tyr Ser His Lys Val Glu Lys Val Ala Asn Leu
 305                 310                 315                 320
 Lys Gln Phe Ser Ser Lys Asp Asp Phe Lys Leu Ala Val Asp Asn Met
                 325                 330                 335    
 Gln Tyr Leu Gly Glu Gly Thr Tyr Thr Ala Thr Ala Leu Gln Ala Ala
             340                 345                 350        
 Asn Asp Met Phe Glu Asp Ala Arg Pro Gly Val Lys Lys Val Ala Leu
         355                 360                 365            
 Val Ile Thr Asp Gly Gln Thr Asp Ser Arg Asp Lys Glu Lys Leu Thr
     370                 375                 380                
 Glu Val Val Lys Asn Ala Ser Asp Thr Asn Val Glu Ile Phe Val Ile
 385                 390                 395                 400
 Gly Val Val Lys Lys Asn Asp Pro Asn Phe Glu Ile Phe His Lys Glu
                 405                 410                 415    
 Met Asn Leu Ile Ala Thr Asp Pro Glu His Val Tyr Gln Phe Asp Asp
             420                 425                 430        
 Phe Phe Thr Leu Gln Asp Thr Leu Lys Gln Lys Leu Phe Gln Lys Ile
         435                 440                 445            
 Cys Glu Asp Phe Asp Ser Tyr Leu Val Gln Ile Phe Gly Ser Ser Ser
     450                 455                 460                
 Pro Gln Pro Gly Phe Gly Met Ser Gly Glu Glu Leu Ser Glu Ser Thr
 465                 470                 475                 480
 Pro Glu Pro Gln Lys Glu Ile Ser Glu Ser Leu Ser Val Thr Arg Asp
                 485                 490                 495    
 Gln Asp Glu Asp Asp Lys Ala Pro Glu Pro Thr Trp Ala Asp Asp Leu
             500                 505                 510        
 Pro Ala Thr Thr Ser Ser Glu Ala Thr Thr Thr Pro Arg Pro Leu Leu
         515                 520                 525            
 Ser Thr Pro Val Asp Gly Ala Glu Asp Pro Arg Cys Leu Glu Ala Leu
     530                 535                 540                
 Lys Pro Gly Asn Cys Gly Glu Tyr Val Val Arg Trp Tyr Tyr Asp Lys
 545                 550                 555                 560
 Gln Val Asn Ser Cys Ala Arg Phe Trp Phe Ser Gly Cys Asn Gly Ser
                 565                 570                 575    
 Gly Asn Arg Phe Asn Ser Glu Lys Glu Cys Gln Glu Thr Cys Ile Gln
             580                 585                 590        
 Gly
    



      <210> 784
      <211> 310
      <212> PRT
      <213> Homo sapiens


      <400> 784
 Met Arg Arg Thr Ala Leu Ile Leu Gly Ser Gly Leu Leu Ser Phe Val
   1               5                  10                  15    
 Ala Phe Trp Asn Ser Val Thr Trp His Leu Gln Arg Phe Trp Gly Ala
              20                  25                  30        
 Ser Gly Tyr Phe Trp Gln Ala Gln Trp Glu Arg Leu Leu Thr Thr Phe
          35                  40                  45            
 Glu Gly Lys Glu Trp Ile Leu Phe Phe Ile Gly Ala Ile Gln Val Pro
      50                  55                  60                
 Cys Leu Phe Phe Trp Ser Phe Asn Gly Leu Leu Leu Val Val Asp Thr
  65                  70                  75                  80
 Thr Gly Lys Pro Asn Phe Ile Ser Arg Tyr Arg Ile Gln Val Gly Lys
                  85                  90                  95    
 Asn Glu Pro Val Asp Pro Val Lys Leu Arg Gln Ser Ile Arg Thr Val
             100                 105                 110        
 Leu Phe Asn Gln Cys Met Ile Ser Phe Pro Met Val Val Phe Leu Tyr
         115                 120                 125            
 Pro Phe Leu Lys Trp Trp Arg Asp Pro Cys Arg Arg Glu Leu Pro Thr
     130                 135                 140                
 Phe His Trp Phe Leu Leu Glu Leu Ala Ile Phe Thr Leu Ile Glu Glu
 145                 150                 155                 160
 Val Leu Phe Tyr Tyr Ser His Arg Leu Leu His His Pro Thr Phe Tyr
                 165                 170                 175    
 Lys Lys Ile His Lys Lys His His Glu Trp Thr Ala Pro Ile Gly Val
             180                 185                 190        
 Ile Ser Leu Tyr Ala His Pro Ile Glu His Ala Val Ser Asn Met Leu
         195                 200                 205            
 Pro Val Ile Val Gly Pro Leu Val Met Gly Ser His Leu Ser Ser Ile
     210                 215                 220                
 Thr Met Trp Phe Ser Leu Ala Leu Ile Ile Thr Thr Ile Ser His Cys
 225                 230                 235                 240
 Gly Tyr His Leu Pro Phe Leu Pro Ser Pro Glu Phe His Asp Tyr His
                 245                 250                 255    
 His Leu Lys Phe Asn Gln Cys Tyr Gly Val Leu Gly Val Leu Asp His
             260                 265                 270        
 Leu His Gly Thr Asp Thr Met Phe Lys Gln Thr Lys Ala Tyr Glu Arg
         275                 280                 285            
 His Val Leu Leu Leu Gly Phe Thr Pro Leu Ser Glu Ser Ile Pro Asp
     290                 295                 300                
 Ser Pro Lys Arg Met Glu
 305                 310



      <210> 785
      <211> 1693
      <212> PRT
      <213> Homo sapiens


      <400> 785
 Met Ala Asn Thr Thr Ile Gly Glu Ser Ser Thr Tyr Ile Thr Asn Val
   1               5                  10                  15    
 Cys Glu Lys Glu Glu Val Tyr Glu Thr Pro Glu Asn Val Ser Gln Ala
              20                  25                  30        
 Ile Thr Pro His Ala Ser Glu Ser Phe Gly Thr Leu Val Asn Val Glu
          35                  40                  45            
 Glu Ser Glu Glu Ile Ala Ser Glu Arg Ile Lys Lys Asp Asp Leu Arg
      50                  55                  60                
 Glu Leu Gln Leu Ser Ala Ser Thr Arg Ile Asp Glu Phe Lys Thr Glu
  65                  70                  75                  80
 Gln Lys Glu Glu Asn Met Arg Phe Phe Glu Asn Ser Phe Arg Lys Arg
                  85                  90                  95    
 Pro Gln Arg Cys Pro Pro Ser Phe Leu Gln Glu Ile Glu Ser Gln Glu
             100                 105                 110        
 Val Tyr Glu Gly Asp Ser Cys Asn Phe Val Cys His Phe Gln Gly Tyr
         115                 120                 125            
 Pro Gln Pro Ile Val Thr Trp Tyr Asn Asn Asp Met Pro Ile Pro Arg
     130                 135                 140                
 Asn Gln Asn Phe Ile Ile His Ser Leu Glu Asn Tyr Ser Ile Leu Thr
 145                 150                 155                 160
 Leu Ser Ser Val His His Gln Asn Glu Gly Ser Ile Thr Cys Val Leu
                 165                 170                 175    
 Phe Asn Gln Tyr Gly Thr Val Lys Thr Thr Ser Met Leu Lys Val Lys
             180                 185                 190        
 Ala Lys Gln Lys His Asp Val Lys Ala His Lys Val Pro Val Phe His
         195                 200                 205            
 Asp Tyr Leu Asp Glu Glu Glu Glu Leu Ala Leu Val Phe Asp Gln Ala
     210                 215                 220                
 Lys Gly Ala His Pro Ser Met Ser Gln Glu Gly Gln Thr Asn Leu His
 225                 230                 235                 240
 Leu Leu Lys Thr Asn Pro Pro Val Pro Pro Ser Gly Asp Thr Glu Leu
                 245                 250                 255    
 Leu Ser Phe Pro Val Glu Ile Gln Val Thr Ala Ala Thr Pro Ile Pro
             260                 265                 270        
 Glu Gln Asp Lys Glu Ser Lys Glu Val Phe Gln Thr Glu Glu Leu Glu
         275                 280                 285            
 Pro Lys Ala Met Pro Gln Asp Gln Val Thr Gln Ser Pro Lys His Arg
     290                 295                 300                
 Phe Val Phe Leu Ser Asp Ile Thr Asn Glu Pro Pro Lys Met Leu Gln
 305                 310                 315                 320
 Glu Met Pro Lys His Ala Arg Cys Arg Glu Gly Asp Ser Ile Ile Leu
                 325                 330                 335    
 Glu Cys Leu Ile Ser Gly Glu Pro Gln Pro Val Val Thr Trp Phe Gln
             340                 345                 350        
 Asn Gly Val Leu Leu Lys Gln Asn Gln Lys Phe Gln Phe Glu Glu Val
         355                 360                 365            
 Asn Cys Ser His Gln Leu Tyr Ile Lys Asp Val Asn Ser Gln Asp Ser
     370                 375                 380                
 Gly Lys Tyr Lys Cys Val Ala Glu Asn Asn Ser Gly Ala Val Glu Ser
 385                 390                 395                 400
 Val Ser Asp Leu Thr Val Glu Pro Val Thr Tyr Arg Glu Asn Ser Gln
                 405                 410                 415    
 Phe Glu Asn Ile Gly Glu Ile Tyr Gly Lys Tyr Ser Arg Asp Gln Gln
             420                 425                 430        
 Leu Gln Asp Gln Gly Glu Ser Val Arg Ala His Phe Tyr Asp Tyr Pro
         435                 440                 445            
 Ala Gly Pro Phe Thr Pro Trp Thr Asn Val Lys Glu Tyr Ser Val Arg
     450                 455                 460                
 Asp Tyr Phe Gln Ser Leu Glu Thr Ile Glu Gln Ile Asp Gln Lys Glu
 465                 470                 475                 480
 Gln Val Arg Cys Ile Pro Ser Arg Glu Lys Ile Pro Arg Phe Val His
                 485                 490                 495    
 Gly Ala Ser Arg Thr Ile Lys Ile Ser Lys Pro Ile Arg Ala Glu Phe
             500                 505                 510        
 Ile Gln Cys Gln Ala Glu Gly Lys Glu Arg His Val Ser Glu Lys Ser
         515                 520                 525            
 Lys Leu His Gln Ala Glu Gly Thr Val Tyr Pro Phe Val Asp Asp Phe
     530                 535                 540                
 Ser Asp Val Thr Ile Lys Lys Glu Ile Arg Asn Asn Phe Gly Lys Leu
 545                 550                 555                 560
 Gly Arg Ser Glu Lys Glu Asn Val Gln Glu Cys Ala Gln Ser Asp Tyr
                 565                 570                 575    
 Leu Pro Asn Ile His Ser Glu Arg Ile Ser Asp Ser Tyr Asn Thr Lys
             580                 585                 590        
 Asp Ser Ser Ala Ile Val Tyr Glu Glu Ser Leu Gly Glu Glu Ile His
         595                 600                 605            
 Tyr Pro Gly Lys Lys Val Lys His Arg Ile Ile Glu Phe Glu Lys Leu
     610                 615                 620                
 His Val Glu Lys Gly Val Leu Glu Lys Arg Pro Thr Arg Thr Ser Ile
 625                 630                 635                 640
 Val Asn Pro Pro Gln Lys Lys Ile Asp Asp Lys Ala Phe Ser Leu Lys
                 645                 650                 655    
 Gln Arg Glu Ser Arg Ser Ser Asn Leu Asn Ala Asn Met Tyr Gln Ala
             660                 665                 670        
 Glu Lys Met Ser Pro Asn Thr Glu Ser Asp Ser Ser Asn Ile Ala Ile
         675                 680                 685            
 Asn Leu Lys Leu Leu Ser Ser Gln Thr His Lys Glu Phe Asp Ala Gln
     690                 695                 700                
 Glu Arg Glu Gln Gln Glu Lys Ile Ser Leu Ile Asp Lys Pro Ala Ile
 705                 710                 715                 720
 Ser Lys Arg Ala Glu His Glu Ser Pro Ile Thr Phe Asp Leu Lys Gln
                 725                 730                 735    
 Phe His Thr Gln Ile Lys His Thr Asp Val Lys Phe Gln Glu Leu Asp
             740                 745                 750        
 Ser Gly Gln Pro Glu Glu Ala Tyr Phe Lys Ile Gln His Pro Ala Asp
         755                 760                 765            
 Thr Glu Asn Ile Val Phe Asp Leu Lys Gln Met Tyr Ser His Ile Gly
     770                 775                 780                
 Asp Pro Ala Leu Glu Phe Gln Gly Gln Glu Thr Arg Glu Gln Gln Glu
 785                 790                 795                 800
 Ile His Tyr Lys Glu Lys Ile Pro Ser Pro Glu Thr Leu Gln Pro Asp
                 805                 810                 815    
 Thr His Asn Ile Ser Lys Ser Val Gln Asn Asn Val Phe Ala Ser Gln
             820                 825                 830        
 Glu Ile Ser Ser Ser Gln Glu Leu Ser Asn Arg Thr Met Val Glu Lys
         835                 840                 845            
 Ser Ser Ile Asp Glu Asn Ser Ile Ser Leu Glu Lys Glu Val Arg His
     850                 855                 860                
 Val Gln Glu Gln Asn Leu Asp Ile Leu Lys Thr Asp Leu Ser Leu Lys
 865                 870                 875                 880
 Ser Phe Ser Glu Glu Ile Tyr Ser Glu Ser Cys Ala Leu Leu Pro Thr
                 885                 890                 895    
 Ser Ser Ala Asp Ile Glu Glu Thr Asp Leu Ser Glu Lys Ser Cys Pro
             900                 905                 910        
 Leu Glu Asn Gly Gly Arg Ser Ser Ile Ser His Leu Lys Lys Ala Ala
         915                 920                 925            
 Ser Glu Glu Lys Pro Leu Gly Val Gly Glu Met Glu Glu Glu Cys Thr
     930                 935                 940                
 Leu Glu Pro Glu Leu Ala Ala Phe Pro Lys Gln Asp Gly Gly Thr Gln
 945                 950                 955                 960
 Glu Tyr Thr Asp Ala Thr Leu Glu Asp His Arg Gly Asp Val Gln Glu
                 965                 970                 975    
 Ala Asp Thr Leu His Arg Gln Leu Ser Leu Ser Gln Cys Phe Pro Leu
             980                 985                 990        
 Leu Met Thr Glu Glu Gln Gln Asn Pro Gly Glu Gln Ile Ser Thr Asn
         995                1000                1005            
 Ile His Ala Ser Gly Glu Glu Lys Cys Tyr Glu Glu Val Gln Val Gln
    1010                1015                1020                
 Asn Glu Ala Ser Phe Ser Thr Leu Glu Gly Glu Met Ile Glu Thr Ser
1025                1030                1035                1040
 Phe Ser Gln Asn Ile Pro Lys Leu Asp Glu Ala His Thr Thr Glu Ala
                1045                1050                1055    
 Ala Glu Ser Glu Thr Ser Leu Thr Gln Tyr Leu Leu Ala Ala Gly Lys
            1060                1065                1070        
 Arg Glu Val Pro Glu Thr Lys Asp Thr Arg Asp Gln Ala Lys Leu Val
        1075                1080                1085            
 Gln Ser Glu Ser Ile Thr Ser Met Glu Val Glu Glu Val Thr Phe Asn
    1090                1095                1100                
 Thr Val Tyr Glu Tyr Tyr Asn Gln Lys Gln Glu Ser Leu Gly Arg Pro
1105                1110                1115                1120
 Leu Ser Pro Glu Ser Asp Ile Ser Ile Gly Val Gly Ser Thr Thr Ser
                1125                1130                1135    
 Glu Glu Ile Ser Glu Leu Asp Gln Phe Tyr Thr Pro Pro Ser Ser Val
            1140                1145                1150        
 Glu Tyr Phe Glu Ser Pro Lys Ser Pro Asp Leu Tyr Phe Asn Pro Ser
        1155                1160                1165            
 Asp Ile Thr Lys Gln Ser Ser Ile His Ser Gly Gly Glu Thr Val Glu
    1170                1175                1180                
 Arg Tyr Ser Thr Pro Leu Gly Glu Val Ala Glu Arg Tyr Ser Thr Pro
1185                1190                1195                1200
 Ser Glu Gly Glu Val Gly Glu Arg Tyr Ser Thr Pro Pro Gly Glu Thr
                1205                1210                1215    
 Leu Glu Arg Tyr Ser Thr Pro Pro Gly Glu Thr Leu Glu Arg Tyr Ser
            1220                1225                1230        
 Thr Pro Pro Gly Glu Thr Leu Glu Arg Tyr Ser Thr Pro Pro Gly Glu
        1235                1240                1245            
 Thr Leu Glu Arg Tyr Ser Thr Pro Pro Gly Glu Thr Leu Glu Arg Tyr
    1250                1255                1260                
 Ser Thr Pro Pro Gly Glu Ala Leu Glu Arg Tyr Ser Ile Pro Thr Gly
1265                1270                1275                1280
 Gly Pro Asn Pro Thr Gly Thr Phe Lys Thr Tyr Pro Ser Lys Ile Glu
                1285                1290                1295    
 Arg Glu Asp Gly Thr Pro Asn Glu His Phe Tyr Thr Pro Thr Glu Glu
            1300                1305                1310        
 Arg Gly Ser Ala Tyr Glu Ile Trp Arg Ser Asp Ser Phe Gly Thr Pro
        1315                1320                1325            
 Asn Glu Ala Ile Glu Pro Lys Asp Asn Glu Met Pro Pro Ser Phe Ile
    1330                1335                1340                
 Glu Pro Leu Thr Lys Arg Lys Val Tyr Glu Asn Thr Thr Leu Gly Phe
1345                1350                1355                1360
 Ile Val Glu Val Glu Gly Leu Pro Val Pro Gly Val Lys Trp Tyr Arg
                1365                1370                1375    
 Asn Lys Ser Leu Leu Glu Pro Asp Glu Arg Ile Lys Met Glu Arg Val
            1380                1385                1390        
 Gly Asn Val Cys Ser Leu Glu Ile Ser Asn Ile Gln Lys Gly Glu Gly
        1395                1400                1405            
 Gly Glu Tyr Met Cys His Ala Val Asn Ile Ile Gly Glu Ala Lys Ser
    1410                1415                1420                
 Phe Ala Asn Val Asp Ile Met Pro Gln Glu Glu Arg Val Val Ala Leu
1425                1430                1435                1440
 Pro Pro Pro Val Thr His Gln His Val Met Glu Phe Asp Leu Glu His
                1445                1450                1455    
 Thr Thr Ser Ser Arg Thr Pro Ser Pro Gln Glu Ile Val Leu Glu Val
            1460                1465                1470        
 Glu Leu Ser Glu Lys Asp Val Lys Glu Phe Glu Lys Gln Val Lys Ile
        1475                1480                1485            
 Val Thr Val Pro Glu Phe Thr Pro Asp His Lys Ser Met Ile Val Ser
    1490                1495                1500                
 Leu Asp Val Leu Pro Phe Asn Phe Val Asp Pro Asn Met Asp Ser Arg
1505                1510                1515                1520
 Glu Gly Glu Asp Lys Glu Leu Lys Ile Asp Leu Glu Val Phe Glu Met
                1525                1530                1535    
 Pro Pro Arg Phe Ile Met Pro Ile Cys Asp Phe Lys Ile Pro Glu Asn
            1540                1545                1550        
 Ser Asp Ala Val Phe Lys Cys Ser Val Ile Gly Ile Pro Thr Pro Glu
        1555                1560                1565            
 Val Lys Trp Tyr Lys Glu Tyr Met Cys Ile Glu Pro Asp Asn Ile Lys
    1570                1575                1580                
 Tyr Val Ile Ser Glu Glu Lys Gly Ser His Thr Leu Lys Ile Arg Asn
1585                1590                1595                1600
 Val Cys Leu Ser Asp Ser Ala Thr Tyr Arg Cys Arg Ala Val Asn Cys
                1605                1610                1615    
 Val Gly Glu Ala Ile Cys Arg Gly Phe Leu Thr Met Gly Asp Ser Glu
            1620                1625                1630        
 Ile Phe Ala Val Ile Ala Lys Lys Ser Lys Val Thr Leu Ser Ser Leu
        1635                1640                1645            
 Met Glu Glu Leu Val Leu Lys Ser Asn Tyr Thr Asp Ser Phe Phe Glu
    1650                1655                1660                
 Phe Gln Val Val Glu Gly Pro Pro Arg Phe Ile Lys Gly Ile Ser Asp
1665                1670                1675                1680
 Cys Tyr Ala Pro Ile Gly Thr Ala Ala Tyr Phe Gln Cys
                1685                1690            



      <210> 786
      <211> 725
      <212> PRT
      <213> Homo sapiens


      <400> 786
 Met Thr Ser Gln Glu Lys Thr Glu Glu Tyr Pro Phe Ala Asp Ile Phe
   1               5                  10                  15    
 Asp Glu Asp Glu Thr Glu Arg Asn Phe Leu Leu Ser Lys Pro Val Cys
              20                  25                  30        
 Phe Val Val Phe Gly Lys Pro Gly Val Gly Lys Thr Thr Leu Ala Arg
          35                  40                  45            
 Tyr Ile Thr Gln Ala Trp Lys Cys Ile Arg Val Glu Ala Leu Pro Ile
      50                  55                  60                
 Leu Glu Glu Gln Ile Ala Ala Glu Thr Glu Ser Gly Val Met Leu Gln
  65                  70                  75                  80
 Ser Met Leu Ile Ser Gly Gln Ser Ile Pro Asp Glu Leu Val Ile Lys
                  85                  90                  95    
 Leu Met Leu Glu Lys Leu Asn Ser Pro Glu Val Cys His Phe Gly Tyr
             100                 105                 110        
 Ile Ile Thr Glu Ile Pro Ser Leu Ser Gln Asp Ala Met Thr Thr Leu
         115                 120                 125            
 Gln Gln Ile Glu Leu Ile Lys Asn Leu Asn Leu Lys Pro Asp Val Ile
     130                 135                 140                
 Ile Asn Ile Lys Cys Pro Asp Tyr Asp Leu Cys Gln Arg Ile Ser Gly
 145                 150                 155                 160
 Gln Arg Gln His Asn Asn Thr Gly Tyr Ile Tyr Ser Arg Asp Gln Trp
                 165                 170                 175    
 Asp Pro Glu Val Ile Glu Asn His Arg Lys Lys Lys Lys Glu Ala Gln
             180                 185                 190        
 Lys Asp Gly Lys Gly Glu Glu Glu Glu Glu Glu Glu Glu Gln Glu Glu
         195                 200                 205            
 Glu Glu Ala Phe Ile Ala Glu Met Gln Met Val Ala Glu Ile Leu His
     210                 215                 220                
 His Leu Val Gln Arg Pro Glu Asp Tyr Leu Glu Asn Val Glu Asn Ile
 225                 230                 235                 240
 Val Lys Leu Tyr Lys Glu Thr Ile Leu Gln Thr Leu Glu Glu Val Met
                 245                 250                 255    
 Ala Glu His Asn Pro Gln Tyr Leu Ile Gly Leu Asn Gly Asn Lys Pro
             260                 265                 270        
 Ala Glu Glu Leu Phe Met Ile Val Met Asp Arg Leu Lys Tyr Leu Asn
         275                 280                 285            
 Leu Lys Arg Ala Ala Ile Leu Thr Lys Leu Gln Gly Ala Glu Glu Glu
     290                 295                 300                
 Ile Asn Asp Thr Met Glu Asn Asp Glu Leu Phe Arg Thr Leu Ala Ser
 305                 310                 315                 320
 Tyr Lys Leu Ile Ala Pro Arg Tyr Arg Trp Gln Arg Ser Lys Trp Gly
                 325                 330                 335    
 Arg Thr Cys Pro Val Asn Leu Lys Asp Gly Asn Ile Tyr Ser Gly Leu
             340                 345                 350        
 Pro Asp Tyr Ser Val Ser Phe Leu Gly Lys Ile Tyr Cys Leu Ser Ser
         355                 360                 365            
 Glu Glu Ala Leu Lys Pro Phe Leu Leu Asn Pro Arg Pro Tyr Leu Leu
     370                 375                 380                
 Pro Pro Met Pro Gly Pro Pro Cys Lys Val Phe Ile Leu Gly Pro Gln
 385                 390                 395                 400
 Tyr Ser Gly Lys Thr Thr Leu Cys Asn Met Leu Ala Glu Asn Tyr Lys
                 405                 410                 415    
 Gly Lys Val Val Asp Tyr Ala Gln Leu Val Gln Pro Arg Phe Asp Lys
             420                 425                 430        
 Ala Arg Glu Thr Leu Val Glu Asn Thr Ile Ala Glu Ala Thr Ala Ala
         435                 440                 445            
 Ala Ile Lys Val Val Lys Glu Lys Leu Leu Arg Glu Leu Gln Ala Arg
     450                 455                 460                
 Lys Gln Ala Glu Thr Ala Leu Arg Glu Phe Gln Arg Gln Tyr Glu Lys
 465                 470                 475                 480
 Met Glu Phe Gly Val Phe Pro Met Glu Ala Thr His Ser Ser Ile Asp
                 485                 490                 495    
 Glu Glu Gly Tyr Ile Gln Gly Ser Gln Arg Asp Arg Gly Ser Ser Leu
             500                 505                 510        
 Val Asp Thr Glu Glu Ala Lys Thr Lys Ser Glu Asn Val Leu His Asp
         515                 520                 525            
 Gln Ala Ala Lys Val Asp Lys Asp Asp Gly Lys Glu Thr Gly Glu Thr
     530                 535                 540                
 Phe Thr Phe Lys Arg His Ser Gln Asp Ala Ser Gln Asp Val Lys Leu
 545                 550                 555                 560
 Tyr Ser Asp Thr Ala Pro Thr Glu Asp Leu Ile Glu Glu Val Thr Ala
                 565                 570                 575    
 Asp His Pro Glu Val Val Thr Met Ile Glu Glu Thr Ile Lys Met Ser
             580                 585                 590        
 Gln Asp Ile Asn Phe Glu Gln Pro Tyr Glu Lys His Ala Glu Ile Leu
         595                 600                 605            
 Gln Glu Val Leu Gly Glu Val Met Glu Glu Asn Lys Asp Arg Phe Pro
     610                 615                 620                
 Gly Ala Pro Lys Tyr Gly Gly Trp Ile Val Asp Asn Cys Pro Ile Val
 625                 630                 635                 640
 Lys Glu Leu Trp Met Ala Leu Ile Lys Lys Gly Ile Ile Pro Asp Leu
                 645                 650                 655    
 Val Ile Tyr Leu Ser Asp Thr Glu Asn Asn Gly Lys Cys Leu Phe Asn
             660                 665                 670        
 Arg Ile Tyr Leu Gln Lys Lys Ser Glu Ile Asp Ser Lys Ile Leu Glu
         675                 680                 685            
 Arg Leu Leu Glu Glu Leu Gln Lys Lys Lys Lys Arg Arg Arg Arg Ser
     690                 695                 700                
 Lys Lys Ser His Arg Arg Gly Ile Glu Thr Arg Arg Arg Lys Ser Lys
 705                 710                 715                 720
 Ala Thr Trp Asn Leu
                 725



      <210> 787
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 787
 Met Glu Arg Cys Asn Ser Ser Thr Leu Leu Gly Asn Cys Ile Lys Ala
   1               5                  10                  15    
 Val Leu Pro Cys Ile Ile Cys Lys Tyr Leu Leu Arg Gln Asn Thr Ser
              20                  25                  30        
 Lys Asp Thr Tyr Glu Met Tyr Thr Tyr Phe Phe Leu His Val Thr Lys
          35                  40                  45            
 Lys Ile Leu Asn Cys Ile Thr Arg Met Phe Asp Lys Leu Phe Phe Phe
      50                  55                  60                





      <210> 788
      <211> 352
      <212> PRT
      <213> Homo sapiens


      <400> 788
 Met Phe Val Ala Leu His Ser Tyr Ser Ala His Gly Pro Asp Glu Leu
   1               5                  10                  15    
 Asp Leu Gln Lys Gly Glu Gly Val Arg Val Leu Gly Lys Cys Gln Asp
              20                  25                  30        
 Gly Trp Leu Arg Gly Val Ser Leu Val Thr Gly Arg Val Gly Ile Phe
          35                  40                  45            
 Pro Asn Asn Tyr Val Ile Pro Ile Phe Arg Lys Thr Ser Ser Phe Pro
      50                  55                  60                
 Asp Ser Arg Ser Pro Gly Leu Tyr Thr Thr Trp Thr Leu Ser Thr Ser
  65                  70                  75                  80
 Ser Val Ser Ser Gln Gly Ser Ile Ser Glu Gly Asp Pro Arg Gln Ser
                  85                  90                  95    
 Arg Pro Phe Lys Ser Val Phe Val Pro Thr Ala Ile Val Asn Pro Val
             100                 105                 110        
 Arg Ser Thr Ala Gly Pro Gly Thr Leu Gly Gln Gly Ser Leu Arg Lys
         115                 120                 125            
 Gly Arg Ser Ser Met Arg Lys Ser Lys Trp Trp Gln Arg Asp Gly Ser
     130                 135                 140                
 Leu Gln Arg Pro Leu Gln Ser Gly Ile Pro Thr Leu Val Val Gly Ser
 145                 150                 155                 160
 Leu Arg Arg Ser Pro Thr Met Val Leu Arg Pro Gln Gln Phe Gln Phe
                 165                 170                 175    
 Tyr Gln Pro Gln Gly Ile Pro Ser Ser Pro Ser Ala Val Val Val Glu
             180                 185                 190        
 Met Gly Ser Lys Pro Ala Leu Thr Gly Glu Pro Ala Leu Thr Cys Ile
         195                 200                 205            
 Ser Arg Gly Ser Glu Ala Arg Ile His Ser Ala Ala Ser Ser Leu Ile
     210                 215                 220                
 Met Glu Asp Lys Glu Ile Pro Ile Lys Ser Glu Pro Leu Pro Lys Pro
 225                 230                 235                 240
 Pro Ala Ser Ala Pro Pro Ser Ile Leu Val Lys Pro Glu Asn Ser Arg
                 245                 250                 255    
 Asn Gly Ile Glu Lys Gln Val Lys Thr Val Arg Phe Gln Asn Tyr Ser
             260                 265                 270        
 Pro Pro Pro Thr Lys His Tyr Thr Ser His Pro Thr Ser Gly Lys Pro
         275                 280                 285            
 Glu Gln Pro Ala Thr Leu Lys Ala Ser Gln Pro Glu Ala Ala Ser Leu
     290                 295                 300                
 Gly Pro Glu Met Thr Val Leu Phe Ala His Arg Ser Gly Cys His Ser
 305                 310                 315                 320
 Gly Gln Gln Thr Asp Leu Arg Arg Lys Ser Ala Leu Ala Lys Ala Thr
                 325                 330                 335    
 Thr Leu Val Ser Thr Ala Ser Gly Thr Gln Thr Val Phe Pro Ser Lys
             340                 345                 350        





      <210> 789
      <211> 425
      <212> PRT
      <213> Homo sapiens


      <400> 789
 Met Val His Ser Pro Ser Gly Arg His Met Val Glu Ile Ser Thr Pro
   1               5                  10                  15    
 Val Leu Ile Ser Ser Ser Asn Pro Ser Val Ile Thr Gln Pro Met Glu
              20                  25                  30        
 Lys Ala Asp Val Pro Ser Ser Cys Val Gly Gln Val Ser Thr Tyr His
          35                  40                  45            
 Pro Ala Pro Val Ser Pro Gly His Ser Thr Ala Val Val Ser Leu Pro
      50                  55                  60                
 Gly Ser Gln Gln His Leu Ser Ala Asn Met Phe Val Ala Leu His Ser
  65                  70                  75                  80
 Tyr Ser Ala His Gly Pro Asp Glu Leu Asp Leu Gln Lys Gly Glu Gly
                  85                  90                  95    
 Val Arg Val Leu Gly Lys Cys Gln Asp Gly Trp Leu Arg Gly Val Ser
             100                 105                 110        
 Leu Val Thr Gly Arg Val Gly Ile Phe Pro Asn Asn Tyr Val Ile Pro
         115                 120                 125            
 Ile Phe Arg Lys Thr Ser Ser Phe Pro Asp Ser Arg Ser Pro Gly Leu
     130                 135                 140                
 Tyr Thr Thr Trp Thr Leu Ser Thr Ser Ser Val Ser Ser Gln Gly Ser
 145                 150                 155                 160
 Ile Ser Glu Gly Asp Pro Arg Gln Ser Arg Pro Phe Lys Ser Val Phe
                 165                 170                 175    
 Val Pro Thr Ala Ile Val Asn Pro Val Arg Ser Thr Ala Gly Pro Gly
             180                 185                 190        
 Thr Leu Gly Gln Gly Ser Leu Arg Lys Gly Arg Ser Ser Met Arg Lys
         195                 200                 205            
 Ser Lys Trp Trp Gln Arg Asp Gly Ser Leu Gln Arg Pro Leu Gln Ser
     210                 215                 220                
 Gly Ile Pro Thr Leu Val Val Gly Ser Leu Arg Arg Ser Pro Thr Met
 225                 230                 235                 240
 Val Leu Arg Pro Gln Gln Phe Gln Phe Tyr Gln Pro Gln Gly Ile Pro
                 245                 250                 255    
 Ser Ser Pro Ser Ala Val Val Val Glu Met Gly Ser Lys Pro Ala Leu
             260                 265                 270        
 Thr Gly Glu Pro Ala Leu Thr Cys Ile Ser Arg Gly Ser Glu Ala Arg
         275                 280                 285            
 Ile His Ser Ala Ala Ser Ser Leu Ile Met Glu Asp Lys Glu Ile Pro
     290                 295                 300                
 Ile Lys Ser Glu Pro Leu Pro Lys Pro Pro Ala Ser Ala Pro Pro Ser
 305                 310                 315                 320
 Ile Leu Val Lys Pro Glu Asn Ser Arg Asn Gly Ile Glu Lys Gln Val
                 325                 330                 335    
 Lys Thr Val Arg Phe Gln Asn Tyr Ser Pro Pro Pro Thr Lys His Tyr
             340                 345                 350        
 Thr Ser His Pro Thr Ser Gly Lys Pro Glu Gln Pro Ala Thr Leu Lys
         355                 360                 365            
 Ala Ser Gln Pro Glu Ala Ala Ser Leu Gly Pro Glu Met Thr Val Leu
     370                 375                 380                
 Phe Ala His Arg Ser Gly Cys His Ser Gly Gln Gln Thr Asp Leu Arg
 385                 390                 395                 400
 Arg Lys Ser Ala Leu Ala Lys Ala Thr Thr Leu Val Ser Thr Ala Ser
                 405                 410                 415    
 Gly Thr Gln Thr Val Phe Pro Ser Lys
             420                 425



      <210> 790
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 790
 Met Ser Arg Met Leu Leu Leu Leu Arg Pro Ser Ala His Asp Met Ala
   1               5                  10                  15    
 Gly Asp Phe Val Pro Pro His Pro Gln Thr Ala Phe Cys Asn Ser Asp
              20                  25                  30        
 Leu Val Ile Arg Ala Lys Phe Val Gly Thr Pro Glu Val Asn Gln Thr
          35                  40                  45            
 Thr Leu Tyr Gln Arg Tyr Glu Ile Lys Met Thr Lys Met Tyr Lys Gly
      50                  55                  60                
 Phe Gln Ala Leu Gly Asp Ala Ala Asp Ile Arg Phe Val Tyr Thr Pro
  65                  70                  75                  80
 Ala Met Glu Ser Val Cys Gly Tyr Phe His Arg Ser His Asn Arg Ser
                  85                  90                  95    
 Glu Glu Phe Leu Ile Ala Gly Lys Leu Gln Asp Gly Leu Leu His Ile
             100                 105                 110        
 Thr Thr Cys Ser Leu Trp Leu Pro Gly Thr Ala
         115                 120            



      <210> 791
      <211> 288
      <212> PRT
      <213> Homo sapiens


      <400> 791
 Met Ser Leu His Ser Gln Ala Ser Ala Thr Thr Arg His Pro Glu Pro
   1               5                  10                  15    
 Arg Arg Thr Glu His Arg Ala Pro Ser Ser Thr Trp Arg Pro Val Ala
              20                  25                  30        
 Leu Thr Leu Leu Thr Leu Cys Leu Val Leu Leu Ile Gly Leu Ala Ala
          35                  40                  45            
 Leu Gly Leu Leu Phe Phe Gln Tyr Tyr Gln Leu Ser Asn Thr Gly Gln
      50                  55                  60                
 Asp Thr Ile Ser Gln Met Glu Glu Arg Leu Gly Asn Thr Ser Gln Glu
  65                  70                  75                  80
 Leu Gln Ser Leu Gln Val Gln Asn Ile Lys Leu Ala Gly Ser Leu Gln
                  85                  90                  95    
 His Val Ala Glu Lys Leu Cys Arg Glu Leu Tyr Asn Lys Ala Gly Gly
             100                 105                 110        
 Tyr Thr Arg Asn Met Val Pro Ala Ser Ala Ser Ser Glu Ser Leu Arg
         115                 120                 125            
 Gln Leu Pro His Met Gly Glu Ser Ala Ala Ala His Arg Cys Ser Pro
     130                 135                 140                
 Cys Thr Glu Gln Trp Lys Trp His Gly Asp Asn Cys Tyr Gln Phe Tyr
 145                 150                 155                 160
 Lys Asp Ser Lys Ser Trp Glu Asp Cys Lys Tyr Phe Cys Leu Ser Glu
                 165                 170                 175    
 Asn Ser Thr Met Leu Lys Ile Asn Lys Gln Glu Asp Leu Glu Phe Ala
             180                 185                 190        
 Ala Ser Gln Ser Tyr Ser Glu Phe Phe Tyr Ser Tyr Trp Thr Gly Leu
         195                 200                 205            
 Leu Arg Pro Asp Ser Gly Lys Ala Trp Leu Trp Met Asp Gly Thr Pro
     210                 215                 220                
 Phe Thr Ser Glu Leu Phe His Ile Ile Ile Asp Val Thr Ser Pro Arg
 225                 230                 235                 240
 Ser Arg Asp Cys Val Ala Ile Leu Asn Gly Met Ile Phe Ser Lys Asp
                 245                 250                 255    
 Cys Lys Glu Leu Lys Arg Cys Val Cys Glu Arg Arg Ala Gly Met Val
             260                 265                 270        
 Lys Pro Glu Ser Leu His Val Pro Pro Glu Thr Leu Gly Glu Gly Asp
         275                 280                 285            





      <210> 792
      <211> 449
      <212> PRT
      <213> Homo sapiens


      <400> 792
 Met Pro Gln Asp Arg Thr Glu Glu Asn Glu Ile Phe Val Asp Leu Ala
   1               5                  10                  15    
 Leu Asn Val Leu Pro Gly Leu Ser Thr Trp Gln Ser Val Ile Lys Leu
              20                  25                  30        
 Asn Asp Phe Phe Val Glu Ile Arg Gly Thr Leu Lys Met Met Cys Glu
          35                  40                  45            
 Ser Phe Ile Tyr Asn Gln Thr Leu Met Lys Lys Leu Gln Glu Thr Asn
      50                  55                  60                
 Tyr Asp Val Met Leu Ile Asp Pro Val Ile Pro Cys Gly Asp Leu Met
  65                  70                  75                  80
 Ala Glu Leu Leu Ala Val Pro Phe Val Leu Thr Leu Arg Ile Ser Val
                  85                  90                  95    
 Gly Gly Asn Met Glu Arg Ser Cys Gly Lys Leu Pro Ala Pro Leu Ser
             100                 105                 110        
 Tyr Val Pro Val Pro Met Thr Gly Leu Thr Asp Arg Met Thr Phe Leu
         115                 120                 125            
 Glu Arg Val Lys Asn Ser Met Leu Ser Val Leu Phe His Phe Trp Ile
     130                 135                 140                
 Gln Asp Tyr Asp Tyr His Phe Trp Glu Glu Phe Tyr Ser Lys Ala Leu
 145                 150                 155                 160
 Gly Arg Pro Thr Thr Leu Cys Glu Thr Val Gly Lys Ala Glu Ile Trp
                 165                 170                 175    
 Leu Ile Arg Thr Tyr Trp Asp Phe Glu Phe Pro Gln Pro Tyr Gln Pro
             180                 185                 190        
 Asn Phe Glu Phe Val Gly Gly Leu His Cys Lys Pro Ala Lys Ala Leu
         195                 200                 205            
 Pro Lys Glu Met Glu Asn Phe Val Gln Ser Ser Gly Glu Asp Gly Ile
     210                 215                 220                
 Val Val Phe Ser Leu Gly Ser Leu Phe Gln Asn Val Thr Glu Glu Lys
 225                 230                 235                 240
 Ala Asn Ile Ile Ala Ser Ala Leu Ala Gln Ile Pro Gln Lys Val Leu
                 245                 250                 255    
 Trp Arg Tyr Lys Gly Lys Lys Pro Ser Thr Leu Gly Ala Asn Thr Arg
             260                 265                 270        
 Leu Tyr Asp Trp Ile Pro Gln Asn Asp Leu Leu Gly His Pro Lys Thr
         275                 280                 285            
 Lys Ala Phe Ile Thr His Gly Gly Met Asn Gly Ile Tyr Glu Ala Ile
     290                 295                 300                
 Tyr His Gly Val Pro Met Val Gly Val Pro Ile Phe Gly Asp Gln Leu
 305                 310                 315                 320
 Asp Asn Ile Ala His Met Lys Ala Lys Gly Ala Ala Val Glu Ile Asn
                 325                 330                 335    
 Phe Lys Thr Met Thr Ser Glu Asp Leu Leu Arg Ala Leu Arg Thr Val
             340                 345                 350        
 Ile Thr Asp Ser Ser Tyr Lys Glu Asn Ala Met Arg Leu Ser Arg Ile
         355                 360                 365            
 His His Asp Gln Pro Val Lys Pro Leu Asp Arg Ala Val Phe Trp Ile
     370                 375                 380                
 Glu Phe Val Met Arg His Lys Gly Ala Lys His Leu Arg Ser Ala Ala
 385                 390                 395                 400
 His Asp Leu Thr Trp Phe Gln His Tyr Ser Ile Asp Val Ile Gly Phe
                 405                 410                 415    
 Leu Leu Thr Cys Val Ala Thr Ala Ile Phe Leu Phe Thr Lys Cys Phe
             420                 425                 430        
 Leu Phe Ser Cys Gln Lys Phe Asn Lys Thr Arg Lys Ile Glu Lys Arg
         435                 440                 445            
 Glu
    



      <210> 793
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 793
 Met Ala Asp Thr Val Leu Phe Glu Phe Leu His Thr Glu Met Val Ala
   1               5                  10                  15    
 Glu Leu Trp Ala His Asp Pro Asp Pro Gly Pro Gly Val Ser Ala Gly
              20                  25                  30        
 Leu Arg Gly Glu Glu Ala Gly Ala Thr Lys Gly Gln Lys Met Ser Leu
          35                  40                  45            
 Ser Val Leu Glu Gly Met Gly Phe Arg Val Gly Gln Ala Leu Gly Glu
      50                  55                  60                
 Arg Leu Pro Arg Glu Thr Leu Ala Phe Arg Glu Glu Leu Asp Val Leu
  65                  70                  75                  80
 Lys Phe Leu Cys Lys Asp Leu Trp Val Ala Val Phe Gln Lys Gln Met
                  85                  90                  95    
 Asp Ser Leu Arg Thr Asn His Gln Gly Thr Tyr Val Leu Gln Asp Asn
             100                 105                 110        
 Ser Phe Pro Leu Leu Leu Pro Met Ala Ser Gly Leu Gln Tyr Leu Glu
         115                 120                 125            
 Glu Ala Pro Lys Phe Leu Ala Phe Thr Cys Gly Leu Leu Arg Gly Ala
     130                 135                 140                
 Leu Tyr Thr Leu Gly Ile Glu Ser Val Val Thr Ala Ser Val Ala Ala
 145                 150                 155                 160
 Leu Pro Val Cys Lys Phe Gln Val Val Ile Pro Lys Ser
                 165                 170            



      <210> 794
      <211> 375
      <212> PRT
      <213> Homo sapiens


      <400> 794
 Met Ala Ala Leu Arg Asp Ala Glu Ile Gln Lys Asp Val Gln Thr Tyr
   1               5                  10                  15    
 Tyr Gly Gln Val Leu Lys Arg Ser Ala Asp Leu Gln Thr Asn Gly Cys
              20                  25                  30        
 Val Thr Thr Ala Arg Pro Val Pro Lys His Ile Arg Glu Ala Leu Gln
          35                  40                  45            
 Asn Val His Glu Glu Val Ala Leu Arg Tyr Tyr Gly Cys Gly Leu Val
      50                  55                  60                
 Ile Pro Glu His Leu Glu Asn Cys Trp Ile Leu Asp Leu Gly Ser Gly
  65                  70                  75                  80
 Ser Gly Arg Asp Cys Tyr Val Leu Ser Gln Leu Val Gly Glu Lys Gly
                  85                  90                  95    
 His Val Thr Gly Ile Asp Met Thr Lys Gly Gln Val Glu Val Ala Glu
             100                 105                 110        
 Lys Tyr Leu Asp Tyr His Met Glu Lys Tyr Gly Phe Gln Ala Ser Asn
         115                 120                 125            
 Val Thr Phe Ile His Gly Tyr Ile Glu Lys Leu Gly Glu Ala Gly Ile
     130                 135                 140                
 Lys Asn Glu Ser His Asp Ile Val Val Ser Asn Cys Val Ile Asn Leu
 145                 150                 155                 160
 Val Pro Asp Lys Gln Gln Val Leu Gln Glu Ala Tyr Arg Val Leu Lys
                 165                 170                 175    
 His Gly Gly Glu Leu Tyr Phe Ser Asp Val Tyr Thr Ser Leu Glu Leu
             180                 185                 190        
 Pro Glu Glu Ile Arg Thr His Lys Val Leu Trp Gly Glu Cys Leu Gly
         195                 200                 205            
 Gly Ala Leu Tyr Trp Lys Glu Leu Ala Val Leu Ala Gln Lys Ile Gly
     210                 215                 220                
 Phe Cys Pro Pro Arg Leu Val Thr Ala Asn Leu Ile Thr Ile Gln Asn
 225                 230                 235                 240
 Lys Glu Leu Glu Arg Val Ile Gly Asp Cys Arg Phe Val Ser Ala Thr
                 245                 250                 255    
 Phe Arg Leu Phe Lys His Ser Lys Thr Gly Pro Thr Lys Arg Cys Gln
             260                 265                 270        
 Val Ile Tyr Asn Gly Gly Ile Thr Gly His Glu Lys Glu Leu Met Phe
         275                 280                 285            
 Asp Ala Asn Phe Thr Phe Lys Glu Gly Glu Ile Val Glu Val Asp Glu
     290                 295                 300                
 Glu Thr Ala Ala Ile Leu Lys Asn Ser Arg Phe Ala Gln Asp Phe Leu
 305                 310                 315                 320
 Ile Arg Pro Ile Gly Glu Lys Leu Pro Thr Ser Gly Gly Cys Ser Ala
                 325                 330                 335    
 Leu Glu Leu Lys Asp Ile Ile Thr Asp Pro Phe Lys Leu Ala Glu Glu
             340                 345                 350        
 Ser Asp Ser Met Lys Ser Arg Cys Val Pro Asp Ala Ala Gly Gly Cys
         355                 360                 365            
 Cys Gly Thr Lys Lys Ser Cys
     370                 375



      <210> 795
      <211> 773
      <212> PRT
      <213> Homo sapiens


      <400> 795
 Met Glu Pro Leu Thr Ala Ser Arg Leu Gln Val Arg Lys Lys Asn Ser
   1               5                  10                  15    
 Leu Lys Asp Cys Val Ala Val Ala Gly Pro Leu Gly Val Thr His Phe
              20                  25                  30        
 Leu Ile Leu Ser Lys Thr Glu Thr Asn Val Tyr Phe Lys Leu Met Arg
          35                  40                  45            
 Leu Pro Gly Gly Pro Thr Leu Thr Phe Gln Val Lys Lys Tyr Ser Leu
      50                  55                  60                
 Val Arg Asp Val Val Ser Ser Leu Arg Arg His Arg Met His Glu Gln
  65                  70                  75                  80
 Gln Phe Ala His Pro Pro Leu Leu Val Leu Asn Ser Phe Gly Pro His
                  85                  90                  95    
 Gly Met His Val Lys Leu Met Ala Thr Met Phe Gln Asn Leu Phe Pro
             100                 105                 110        
 Ser Ile Asn Val His Lys Val Asn Leu Asn Thr Ile Lys Arg Cys Leu
         115                 120                 125            
 Leu Ile Asp Tyr Asn Pro Asp Ser Gln Glu Leu Asp Phe Arg His Tyr
     130                 135                 140                
 Ser Ile Lys Val Val Pro Val Gly Ala Ser Arg Gly Met Lys Lys Leu
 145                 150                 155                 160
 Leu Gln Glu Lys Phe Pro Asn Met Ser Arg Leu Gln Asp Ile Ser Glu
                 165                 170                 175    
 Leu Leu Ala Thr Gly Ala Gly Leu Ser Glu Ser Glu Ala Glu Pro Asp
             180                 185                 190        
 Gly Asp His Asn Ile Thr Glu Leu Pro Gln Ala Val Ala Gly Arg Gly
         195                 200                 205            
 Asn Met Arg Ala Gln Gln Ser Ala Val Arg Leu Thr Glu Ile Gly Pro
     210                 215                 220                
 Arg Met Thr Leu Gln Leu Ile Lys Val Gln Glu Gly Val Gly Glu Gly
 225                 230                 235                 240
 Lys Val Met Phe His Ser Phe Val Ser Lys Thr Glu Glu Glu Leu Gln
                 245                 250                 255    
 Ala Ile Leu Glu Ala Lys Glu Lys Lys Leu Arg Leu Lys Ala Gln Arg
             260                 265                 270        
 Gln Ala Gln Gln Ala Gln Asn Val Gln Arg Lys Gln Glu Gln Arg Glu
         275                 280                 285            
 Ala His Arg Lys Lys Ser Leu Glu Gly Met Lys Lys Ala Arg Val Gly
     290                 295                 300                
 Gly Ser Asp Glu Glu Ala Ser Gly Ile Pro Ser Arg Thr Ala Ser Leu
 305                 310                 315                 320
 Glu Leu Gly Glu Asp Asp Asp Glu Gln Glu Asp Asp Asp Ile Glu Tyr
                 325                 330                 335    
 Phe Cys Gln Ala Val Gly Glu Ala Pro Ser Glu Asp Leu Phe Pro Glu
             340                 345                 350        
 Ala Lys Gln Lys Arg Leu Ala Lys Ser Pro Gly Arg Lys Arg Lys Arg
         355                 360                 365            
 Trp Glu Met Asp Arg Gly Arg Gly Arg Leu Cys Asp Gln Lys Phe Pro
     370                 375                 380                
 Lys Thr Lys Asp Lys Ser Gln Gly Ala Gln Ala Arg Arg Gly Pro Arg
 385                 390                 395                 400
 Gly Ala Ser Arg Asp Gly Ala Lys Ser Cys Pro Ala Asn Phe Leu Ala
                 405                 410                 415    
 Ala Ala Asp Asp Lys Leu Ser Gly Phe Gln Gly Asp Phe Leu Trp Pro
             420                 425                 430        
 Ile Leu Val Val Glu Phe Leu Val Ala Val Ala Ser Asn Gly Leu Ala
         435                 440                 445            
 Leu Tyr Arg Phe Ser Ile Arg Lys Gln Arg Pro Trp His Pro Ala Val
     450                 455                 460                
 Val Phe Ser Val Gln Leu Ala Val Ser Asp Leu Leu Cys Ala Leu Thr
 465                 470                 475                 480
 Leu Pro Pro Leu Ala Ala Tyr Leu Tyr Pro Pro Lys His Trp Arg Tyr
                 485                 490                 495    
 Gly Glu Ala Ala Cys Arg Leu Glu Arg Phe Leu Phe Thr Cys Asn Leu
             500                 505                 510        
 Leu Gly Ser Val Ile Phe Ile Thr Cys Ile Ser Leu Asn Arg Tyr Leu
         515                 520                 525            
 Gly Ile Val His Pro Phe Phe Ala Arg Ser His Leu Arg Pro Lys His
     530                 535                 540                
 Ala Trp Ala Val Ser Ala Ala Gly Trp Val Leu Ala Ala Leu Leu Ala
 545                 550                 555                 560
 Met Pro Thr Leu Ser Phe Ser His Leu Lys Arg Pro Gln Gln Gly Ala
                 565                 570                 575    
 Gly Asn Cys Ser Val Ala Arg Pro Glu Ala Cys Ile Lys Cys Leu Gly
             580                 585                 590        
 Thr Ala Asp His Gly Leu Ala Ala Tyr Arg Ala Tyr Ser Leu Val Leu
         595                 600                 605            
 Ala Gly Leu Gly Cys Gly Leu Pro Leu Leu Leu Thr Leu Ala Ala Tyr
     610                 615                 620                
 Gly Ala Leu Gly Arg Ala Val Leu Arg Ser Pro Gly Met Thr Val Ala
 625                 630                 635                 640
 Glu Lys Leu Arg Val Ala Ala Leu Val Ala Ser Gly Val Ala Leu Tyr
                 645                 650                 655    
 Ala Ser Ser Tyr Val Pro Tyr His Ile Met Arg Val Leu Asn Val Asp
             660                 665                 670        
 Ala Arg Arg Arg Trp Ser Thr Arg Cys Pro Ser Phe Ala Asp Ile Ala
         675                 680                 685            
 Gln Ala Thr Ala Ala Leu Glu Leu Gly Pro Tyr Val Gly Tyr Gln Val
     690                 695                 700                
 Met Arg Gly Leu Met Pro Leu Ala Phe Cys Val His Pro Leu Leu Tyr
 705                 710                 715                 720
 Met Ala Ala Val Pro Ser Leu Gly Cys Cys Cys Arg His Cys Pro Gly
                 725                 730                 735    
 Tyr Arg Asp Ser Trp Asn Pro Glu Asp Ala Lys Ser Thr Gly Gln Ala
             740                 745                 750        
 Leu Pro Leu Asn Ala Thr Ala Ala Pro Lys Pro Ser Glu Pro Gln Ser
         755                 760                 765            
 Arg Glu Leu Ser Gln
     770            



      <210> 796
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 796
 Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr
   1               5                  10                  15    
 Ser Ile Ala Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu
              20                  25                  30        
 Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr
          35                  40                  45            
 Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile
      50                  55                  60                
 Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val
  65                  70                  75                  80
 Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu
                  85                  90                  95    
 Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys
             100                 105                 110        
 Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala
         115                 120                 125            
 Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His
     130                 135                 140                
 His Leu Asp Asn Arg Tyr Cys Ser Pro Trp Arg Ala Thr Ser Ala Met
 145                 150                 155                 160
 Gln Thr
        



      <210> 797
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 797
 Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr
   1               5                  10                  15    
 Ser Ile Ala Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu
              20                  25                  30        
 Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr
          35                  40                  45            
 Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile
      50                  55                  60                
 Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val
  65                  70                  75                  80
 Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu
                  85                  90                  95    
 Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys
             100                 105                 110        
 Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala
         115                 120                 125            
 Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His
     130                 135                 140                
 His Leu Asp Asn Arg Tyr Cys Ser Pro Trp Arg Ala Thr Ser Ala Met
 145                 150                 155                 160
 Gln Thr
        



      <210> 798
      <211> 305
      <212> PRT
      <213> Homo sapiens


      <400> 798
 Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr
   1               5                  10                  15    
 Ser Ile Ala Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu
              20                  25                  30        
 Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr
          35                  40                  45            
 Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile
      50                  55                  60                
 Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val
  65                  70                  75                  80
 Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu
                  85                  90                  95    
 Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys
             100                 105                 110        
 Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala
         115                 120                 125            
 Ser Thr Pro Ala Pro Thr Thr Pro Thr Ser Thr Thr Phe Thr Ala Pro
     130                 135                 140                
 Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His His
 145                 150                 155                 160
 Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro Leu
                 165                 170                 175    
 Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu Ala
             180                 185                 190        
 Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro Glu
         195                 200                 205            
 Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu Thr
     210                 215                 220                
 Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu Ser
 225                 230                 235                 240
 Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala Ser
                 245                 250                 255    
 Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala Glu
             260                 265                 270        
 Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His Leu
         275                 280                 285            
 Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser Arg
     290                 295                 300                
 Pro
 305



      <210> 799
      <211> 409
      <212> PRT
      <213> Homo sapiens


      <400> 799
 Met Ser Arg Arg Arg Ile Ser Cys Lys Asp Leu Gly His Ala Asp Cys
   1               5                  10                  15    
 Gln Gly Trp Leu Tyr Lys Lys Lys Glu Lys Gly Ser Phe Leu Ser Asn
              20                  25                  30        
 Lys Trp Lys Lys Phe Trp Val Ile Leu Lys Gly Ser Ser Leu Tyr Trp
          35                  40                  45            
 Tyr Ser Asn Gln Met Ala Glu Lys Ala Asp Gly Phe Val Asn Leu Pro
      50                  55                  60                
 Asp Phe Thr Val Glu Arg Ala Ser Glu Cys Lys Lys Lys His Ala Phe
  65                  70                  75                  80
 Lys Ile Ser His Pro Gln Ile Lys Thr Phe Tyr Phe Ala Ala Glu Asn
                  85                  90                  95    
 Val Gln Glu Met Asn Val Trp Leu Asn Lys Leu Gly Ser Ala Val Ile
             100                 105                 110        
 His Gln Glu Ser Thr Thr Lys Asp Glu Glu Cys Tyr Ser Glu Ser Glu
         115                 120                 125            
 Gln Glu Asp Pro Glu Ile Ala Ala Glu Thr Pro Pro Pro Pro His Ala
     130                 135                 140                
 Ser Gln Thr Gln Ser Leu Thr Ala Gln Gln Ala Ser Ser Ser Ser Pro
 145                 150                 155                 160
 Ser Leu Ser Gly Thr Ser Tyr Ser Phe Ser Ser Leu Glu Asn Thr Val
                 165                 170                 175    
 Lys Thr Pro Ser Ser Phe Pro Ser Ser Leu Ser Lys Glu Arg Gln Ser
             180                 185                 190        
 Leu Pro Asp Thr Val Asn Ser Leu Ser Ala Ala Glu Asp Glu Gly Gln
         195                 200                 205            
 Pro Ile Thr Phe Ala Val Gln Val His Ser Pro Val Pro Ser Glu Ala
     210                 215                 220                
 Gly Ile His Lys Ala Leu Glu Asn Ser Phe Val Thr Ser Glu Ser Gly
 225                 230                 235                 240
 Phe Leu Asn Ser Leu Ser Ser Asp Asp Thr Ser Ser Leu Ser Ser Asn
                 245                 250                 255    
 His Asp His Leu Thr Val Pro Asp Lys Pro Ala Gly Ser Lys Ile Met
             260                 265                 270        
 Asp Lys Glu Glu Thr Lys Val Ser Glu Asp Asp Glu Met Glu Lys Leu
         275                 280                 285            
 Tyr Lys Ser Leu Glu Gln Ala Ser Leu Ser Pro Leu Gly Asp Arg Arg
     290                 295                 300                
 Pro Ser Thr Lys Lys Glu Leu Arg Lys Ser Phe Val Lys Arg Cys Lys
 305                 310                 315                 320
 Asn Pro Ser Ile Asn Glu Lys Leu His Lys Ile Arg Thr Leu Asn Ser
                 325                 330                 335    
 Thr Leu Lys Cys Lys Glu His Asp Leu Ala Met Ile Asn Gln Leu Leu
             340                 345                 350        
 Asp Asp Pro Lys Leu Thr Ala Arg Lys Tyr Arg Glu Trp Lys Val Met
         355                 360                 365            
 Asn Thr Leu Leu Ile Gln Asp Ile Tyr Gln Gln Gln Arg Ala Ser Pro
     370                 375                 380                
 Ala Pro Asp Asp Thr Asp Asp Thr Pro Gln Glu Leu Lys Lys Ser Pro
 385                 390                 395                 400
 Ser Ser Pro Ser Val Glu Asn Ser Ile
                 405                



      <210> 800
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 800
 Met Gly Lys Glu Ser Gly Trp Asp Ser Val Val Ala Val Gly Thr Val
   1               5                  10                  15    
 Leu Val Ala Leu Ser Ala Met Gly Phe Thr Ser Val Gly Ile Ala Ala
              20                  25                  30        
 Ser Ser Ile Ala Ala Lys Met Met Ser Thr Ala Ala Ile Ala Asn Gly
          35                  40                  45            
 Gly Gly Val Ala Ala Gly Ser Leu Val Ala Ile Leu Gln Ser Val Gly
      50                  55                  60                
 Ala Ala Gly Leu Ser Val Thr Ser Lys Val Ile Gly Gly Phe Ala Gly
  65                  70                  75                  80
 Thr Ala Leu Gly Ala Trp Leu Gly Ser Pro Pro Ser Ser
                  85                  90            



      <210> 801
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 801
 Met Arg Met Val Arg Leu Asp Ile Ser Glu Gly Arg Ala Ala Val Ala
   1               5                  10                  15    
 Ala Val Val Gly Gly Val Val Ala Val Gly Thr Val Leu Val Ala Leu
              20                  25                  30        
 Ser Ala Met Gly Phe Thr Ser Val Gly Ile Ala Ala Ser Ser Ile Ala
          35                  40                  45            
 Ala Lys Met Met Ser Thr Ala Ala Ile Ala Asn Gly Gly Gly Val Ala
      50                  55                  60                
 Ala Gly Ser Leu Val Ala Ile Leu Gln Ser Val Gly Ala Ala Gly Leu
  65                  70                  75                  80
 Ser Val Thr Ser Lys Val Ile Gly Gly Phe Ala Gly Thr Ala Leu Gly
                  85                  90                  95    
 Ala Trp Leu Gly Ser Pro Pro Ser Ser
             100                 105



      <210> 802
      <211> 805
      <212> PRT
      <213> Homo sapiens


      <400> 802
 Met Ala Ala Ser Gly Val Pro Arg Gly Cys Asp Ile Leu Ile Val Tyr
   1               5                  10                  15    
 Ser Pro Asp Ala Glu Glu Trp Cys Gln Tyr Leu Gln Thr Leu Phe Leu
              20                  25                  30        
 Ser Ser Arg Gln Val Arg Ser Gln Lys Ile Leu Thr His Arg Leu Gly
          35                  40                  45            
 Pro Glu Ala Ser Phe Ser Ala Glu Asp Leu Ser Leu Phe Leu Ser Thr
      50                  55                  60                
 Arg Cys Val Val Val Leu Leu Ser Ala Glu Leu Val Gln His Phe His
  65                  70                  75                  80
 Lys Pro Ala Leu Leu Pro Leu Leu Gln Arg Ala Phe His Pro Pro His
                  85                  90                  95    
 Arg Val Val Arg Leu Leu Cys Gly Val Arg Asp Ser Glu Glu Phe Leu
             100                 105                 110        
 Asp Phe Phe Pro Asp Trp Ala His Trp Gln Glu Leu Thr Cys Asp Asp
         115                 120                 125            
 Glu Pro Glu Thr Tyr Val Ala Ala Val Lys Lys Ala Ile Ser Glu Asp
     130                 135                 140                
 Ser Gly Cys Asp Ser Val Thr Asp Thr Glu Pro Glu Asp Glu Lys Val
 145                 150                 155                 160
 Val Ser Tyr Ser Lys Gln Gln Asn Leu Pro Thr Val Thr Ser Pro Gly
                 165                 170                 175    
 Asn Leu Met Val Val Gln Pro Asp Arg Ile Arg Cys Gly Ala Glu Thr
             180                 185                 190        
 Thr Val Tyr Val Ile Val Arg Cys Lys Leu Asp Asp Arg Val Ala Thr
         195                 200                 205            
 Glu Ala Glu Phe Ser Pro Glu Asp Ser Pro Ser Val Arg Met Glu Ala
     210                 215                 220                
 Lys Val Glu Asn Glu Tyr Thr Ile Ser Val Lys Ala Pro Asn Leu Ser
 225                 230                 235                 240
 Ser Gly Asn Val Ser Leu Lys Ile Tyr Ser Gly Asp Leu Val Val Cys
                 245                 250                 255    
 Glu Thr Val Ile Ser Tyr Tyr Thr Asp Met Glu Glu Ile Gly Asn Leu
             260                 265                 270        
 Leu Ser Asn Ala Ala Asn Pro Val Glu Phe Met Cys Gln Ala Phe Lys
         275                 280                 285            
 Ile Val Pro Tyr Asn Thr Glu Thr Leu Asp Lys Leu Leu Thr Glu Ser
     290                 295                 300                
 Leu Lys Asn Asn Ile Pro Ala Ser Gly Leu His Leu Phe Gly Ile Asn
 305                 310                 315                 320
 Gln Leu Glu Glu Glu Asp Met Met Thr Asn Gln Arg Asp Glu Glu Leu
                 325                 330                 335    
 Pro Thr Leu Leu His Phe Ala Ala Lys Tyr Gly Leu Lys Asn Leu Thr
             340                 345                 350        
 Ala Leu Leu Leu Thr Cys Pro Gly Ala Leu Gln Ala Tyr Ser Val Ala
         355                 360                 365            
 Asn Lys His Gly His Tyr Pro Asn Thr Ile Ala Glu Lys His Gly Phe
     370                 375                 380                
 Arg Asp Leu Arg Gln Phe Ile Asp Glu Tyr Val Glu Thr Val Asp Met
 385                 390                 395                 400
 Leu Lys Ser His Ile Lys Glu Glu Leu Met His Gly Glu Glu Ala Asp
                 405                 410                 415    
 Ala Val Tyr Glu Ser Met Ala His Leu Ser Thr Asp Leu Leu Met Lys
             420                 425                 430        
 Cys Ser Leu Asn Pro Gly Cys Asp Glu Asp Leu Tyr Glu Ser Met Ala
         435                 440                 445            
 Ala Phe Val Pro Ala Ala Thr Glu Asp Leu Tyr Val Glu Met Leu Gln
     450                 455                 460                
 Ala Ser Thr Ser Asn Pro Ile Pro Gly Asp Gly Phe Ser Arg Ala Thr
 465                 470                 475                 480
 Lys Asp Ser Met Ile Arg Lys Phe Leu Glu Gly Asn Ser Met Gly Met
                 485                 490                 495    
 Thr Asn Leu Glu Arg Asp Gln Cys His Leu Gly Gln Glu Glu Asp Val
             500                 505                 510        
 Tyr His Thr Val Asp Asp Asp Glu Ala Phe Ser Val Asp Leu Ala Ser
         515                 520                 525            
 Arg Pro Pro Val Pro Val Pro Arg Pro Glu Thr Thr Ala Pro Gly Ala
     530                 535                 540                
 His Gln Leu Pro Asp Asn Glu Pro Tyr Ile Phe Lys Val Phe Ala Glu
 545                 550                 555                 560
 Lys Ser Gln Glu Arg Pro Gly Asn Phe Tyr Val Ser Ser Glu Ser Ile
                 565                 570                 575    
 Arg Lys Gly Pro Pro Val Arg Pro Trp Arg Asp Arg Pro Gln Ser Ser
             580                 585                 590        
 Ile Tyr Asp Pro Phe Ala Gly Met Lys Thr Pro Gly Gln Arg Gln Leu
         595                 600                 605            
 Ile Thr Leu Gln Glu Gln Val Lys Leu Gly Ile Val Asn Val Asp Glu
     610                 615                 620                
 Ala Val Leu His Phe Lys Glu Trp Gln Leu Asn Gln Lys Lys Arg Ser
 625                 630                 635                 640
 Glu Ser Phe Arg Phe Gln Gln Glu Asn Leu Lys Arg Leu Arg Asp Ser
                 645                 650                 655    
 Ile Thr Arg Arg Gln Arg Glu Lys Gln Lys Ser Gly Lys Gln Thr Asp
             660                 665                 670        
 Leu Glu Ile Thr Val Pro Ile Arg His Ser Gln His Leu Pro Ala Lys
         675                 680                 685            
 Val Glu Phe Gly Val Tyr Glu Ser Gly Pro Arg Lys Ser Val Ile Pro
     690                 695                 700                
 Pro Arg Thr Glu Leu Arg Arg Gly Asp Trp Lys Thr Asp Ser Thr Ser
 705                 710                 715                 720
 Ser Thr Ala Ser Ser Thr Ser Asn Arg Ser Ser Thr Arg Ser Leu Leu
                 725                 730                 735    
 Ser Val Ser Ser Gly Met Glu Gly Asp Asn Glu Asp Asn Glu Val Pro
             740                 745                 750        
 Glu Val Thr Arg Ser Arg Ser Pro Gly Pro Pro Gln Val Asp Gly Thr
         755                 760                 765            
 Pro Thr Met Ser Leu Glu Arg Pro Pro Arg Val Pro Pro Arg Ala Ala
     770                 775                 780                
 Ser Gln Arg Pro Pro Thr Arg Glu Thr Phe His Pro Pro Pro Pro Val
 785                 790                 795                 800
 Pro Pro Arg Gly Arg
                 805



      <210> 803
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 803
 Met Leu Leu Ala Trp Gln Gly Lys Ala Gly Arg Lys Ile Leu Gly Lys
   1               5                  10                  15    
 Trp Pro Ala Val Leu Thr Leu Val Leu Trp Ala Ile Trp Lys Met Ile
              20                  25                  30        
 Leu Leu Arg Ala Ala Lys His Val Leu Ile Cys Asn Leu Gln Ile Ser
          35                  40                  45            
 Phe Thr Tyr Met Val Leu Phe Asn Pro Asp Thr Arg Gln Gly Gly Met
      50                  55                  60                
 Trp Phe Ser Asn Phe Cys Val Tyr Gly Asn His Leu Gly Val Ser Leu
  65                  70                  75                  80
 Lys Phe Arg Phe Gln Glu Phe Leu Ala His Gly Gly Ser Asn Asn Ser
                  85                  90                  95    
 Arg Lys Gly His
             100



      <210> 804
      <211> 332
      <212> PRT
      <213> Homo sapiens


      <400> 804
 Met Leu Trp Leu Phe Gln Ser Leu Leu Phe Val Phe Cys Phe Gly Pro
   1               5                  10                  15    
 Gly Asn Val Val Ser Gln Ser Ser Leu Thr Pro Leu Met Val Asn Gly
              20                  25                  30        
 Ile Leu Gly Glu Ser Val Thr Leu Pro Leu Glu Phe Pro Ala Gly Glu
          35                  40                  45            
 Lys Val Asn Phe Ile Thr Trp Leu Phe Asn Glu Thr Ser Leu Ala Phe
      50                  55                  60                
 Ile Val Pro His Glu Thr Lys Ser Pro Glu Ile His Val Thr Asn Pro
  65                  70                  75                  80
 Lys Gln Gly Lys Arg Leu Asn Phe Thr Gln Ser Tyr Ser Leu Gln Leu
                  85                  90                  95    
 Ser Asn Leu Lys Met Glu Asp Thr Gly Ser Tyr Arg Ala Gln Ile Ser
             100                 105                 110        
 Thr Lys Thr Ser Ala Lys Leu Ser Ser Tyr Thr Leu Arg Ile Leu Arg
         115                 120                 125            
 Gln Leu Arg Asn Ile Gln Val Thr Asn His Ser Gln Leu Phe Gln Asn
     130                 135                 140                
 Met Thr Cys Glu Leu His Leu Thr Cys Ser Val Glu Asp Ala Asp Asp
 145                 150                 155                 160
 Asn Val Ser Phe Arg Trp Glu Ala Leu Gly Asn Thr Leu Ser Ser Gln
                 165                 170                 175    
 Pro Asn Leu Thr Val Ser Trp Asp Pro Arg Ile Ser Ser Glu Gln Asp
             180                 185                 190        
 Tyr Thr Cys Ile Ala Glu Asn Ala Val Ser Asn Leu Ser Phe Ser Val
         195                 200                 205            
 Ser Ala Gln Lys Leu Cys Glu Asp Val Lys Ile Gln Tyr Thr Asp Thr
     210                 215                 220                
 Lys Met Ile Leu Phe Met Val Ser Gly Ile Cys Ile Val Phe Gly Phe
 225                 230                 235                 240
 Ile Ile Leu Leu Leu Leu Val Leu Arg Lys Arg Arg Asp Ser Leu Ser
                 245                 250                 255    
 Leu Ser Thr Gln Arg Thr Gln Gly Pro Ala Glu Ser Ala Arg Asn Leu
             260                 265                 270        
 Glu Tyr Val Ser Val Ser Pro Thr Asn Asn Thr Val Tyr Ala Ser Val
         275                 280                 285            
 Thr His Ser Asn Arg Glu Thr Glu Ile Trp Thr Pro Arg Glu Asn Asp
     290                 295                 300                
 Thr Ile Thr Ile Tyr Ser Thr Ile Asn His Ser Lys Glu Ser Lys Pro
 305                 310                 315                 320
 Thr Phe Ser Arg Ala Thr Ala Leu Asp Asn Val Val
                 325                 330        



      <210> 805
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 805
 Met Ser Leu Asp Gln Leu Tyr Phe Ala Arg Pro Val Pro Leu His Ser
   1               5                  10                  15    
 Gly Tyr Arg Cys Pro Leu Gln Gly Leu Tyr Leu Cys Gly Ser Gly Ala
              20                  25                  30        
 His Pro Gly Gly Gly Val Met Gly Ala Ala Gly Arg Asn Ala Ala His
          35                  40                  45            
 Val Ala Phe Arg Asp Leu Lys Ser Met
      50                  55        



      <210> 806
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 806
 Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met
   1               5                  10                  15    
 Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr
              20                  25                  30        
 Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile
          35                  40                  45            
 Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His
      50                  55                  60                
 Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu
  65                  70                  75                  80
 Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Leu
                  85                  90                  95    
 Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu
             100                 105                 110        





      <210> 807
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 807
 Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met
   1               5                  10                  15    
 Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr
              20                  25                  30        
 Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile
          35                  40                  45            
 Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His
      50                  55                  60                
 Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu
  65                  70                  75                  80
 Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Leu
                  85                  90                  95    
 Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu
             100                 105                 110        
 Tyr Gln Trp Asn Tyr Leu Val Thr Ile His Ser Asp Arg Thr Thr Gly
         115                 120                 125            
 Met Ser Pro Thr Glu
     130            



      <210> 808
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 808
 Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met
   1               5                  10                  15    
 Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr
              20                  25                  30        
 Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile
          35                  40                  45            
 Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His
      50                  55                  60                
 Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu
  65                  70                  75                  80
 Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Leu
                  85                  90                  95    
 Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu
             100                 105                 110        





      <210> 809
      <211> 193
      <212> PRT
      <213> Homo sapiens


      <400> 809
 Met Ala Pro Pro Leu Arg Pro Leu Ala Arg Leu Arg Pro Pro Gly Met
   1               5                  10                  15    
 Leu Leu Arg Ala Leu Leu Leu Leu Leu Leu Leu Ser Pro Leu Pro Gly
              20                  25                  30        
 Leu Arg Glu Gly Ile Gly Glu Leu Ile Thr Pro Ile Gly Thr Ser Leu
          35                  40                  45            
 Pro Asp Leu Asp Pro Ala Arg Arg Arg Trp Glu Gly Gly Ile Gly Arg
      50                  55                  60                
 Val Gly Ser Glu Val Ala Asp Leu Cys Pro Gly Lys Glu Gly Gly Lys
  65                  70                  75                  80
 Val Pro Glu Ala Glu Lys Glu Gly Val Trp Cys Phe Ser Glu Leu Ser
                  85                  90                  95    
 Phe Val Lys Glu Pro Gln Asp Val Thr Val Thr Arg Lys Asp Pro Val
             100                 105                 110        
 Val Leu Asp Cys Gln Ala His Gly Glu Val Pro Ile Lys Val Thr Trp
         115                 120                 125            
 Leu Lys Asn Gly Ala Lys Met Ser Glu Asn Lys Arg Ile Glu Val Leu
     130                 135                 140                
 Ser Asn Gly Ser Leu Tyr Ile Ser Glu Val Glu Gly Arg Arg Gly Glu
 145                 150                 155                 160
 Gln Ser Asp Glu Gly Phe Tyr Gln Cys Leu Ala Met Asn Lys Tyr Gly
                 165                 170                 175    
 Ala Ile Leu Ser Gln Lys Ala His Leu Ala Leu Ser Arg Ile Gly Ser
             180                 185                 190        
 Thr
    



      <210> 810
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 810
 Met Glu His Ser Glu Gly Ala Pro Gly Asp Pro Ala Gly Thr Val Val
   1               5                  10                  15    
 Pro Gln Glu Leu Leu Glu Glu Met Leu Trp Phe Phe Arg Val Glu Asp
              20                  25                  30        
 Ala Ser Pro Trp Asn His Ser Ile Leu Ala Leu Ala Ala Val Val Val
          35                  40                  45            
 Ile Ile Ser Met Val Leu Leu Gly Arg Ser Ile Gln Ala Ser Arg Lys
      50                  55                  60                
 Glu Lys Met Gln Pro Pro Glu Lys Glu Thr Pro Glu Val Leu His Leu
  65                  70                  75                  80
 Asp Glu Ala Lys Asp His Asn Ser Leu Asn Asn Leu Arg Glu Thr Leu
                  85                  90                  95    
 Leu Ser Glu Lys Pro Asn Leu Ala Gln Val Glu Leu Glu Leu Lys Glu
             100                 105                 110        
 Arg Asp Val Leu Ser Val Phe Leu Pro Asp Val Pro Glu Thr Glu Ser
         115                 120                 125            





      <210> 811
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 811
 Met Ala Ala Ala Ala Ile Pro Ala Leu Leu Leu Cys Leu Pro Leu Leu
   1               5                  10                  15    
 Phe Leu Leu Phe Gly Trp Ser Arg Ala Arg Arg Asp Asp Pro His Ser
              20                  25                  30        
 Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg
          35                  40                  45            
 Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr
      50                  55                  60                
 Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys
  65                  70                  75                  80
 Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu
                  85                  90                  95    
 Val Val Asp Ile Leu Thr Glu Gln Leu Arg Asp Ile Gln Leu Glu Asn
             100                 105                 110        
 Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu
         115                 120                 125            
 Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln Phe Ser Ile Asp
     130                 135                 140                
 Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg Met Trp Thr Thr
 145                 150                 155                 160
 Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys
                 165                 170                 175    
 Asp Val Ala Met Ser Phe His Tyr Ile Ser Met Gly Asp Cys Ile Gly
             180                 185                 190        
 Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser
         195                 200                 205            
 Ala Gly Asp Thr
     210        



      <210> 812
      <211> 545
      <212> PRT
      <213> Homo sapiens


      <400> 812
 Met Ile Asn Asn Ala Met Gln Ala Asp Asp Ser Gly His Arg Thr Arg
   1               5                  10                  15    
 Arg Tyr Thr Leu Phe Asn Asn Gly Thr Leu Tyr Phe Asn Lys Val Gly
              20                  25                  30        
 Val Ala Glu Glu Gly Asp Tyr Thr Cys Tyr Ala Gln Asn Thr Leu Gly
          35                  40                  45            
 Lys Asp Glu Met Lys Val His Leu Thr Val Ile Thr Ala Ala Pro Arg
      50                  55                  60                
 Ile Arg Gln Ser Asn Lys Thr Asn Lys Arg Ile Lys Ala Gly Asp Thr
  65                  70                  75                  80
 Ala Val Leu Asp Cys Glu Val Thr Gly Asp Pro Lys Pro Lys Ile Phe
                  85                  90                  95    
 Trp Leu Leu Pro Ser Asn Asp Met Ile Ser Phe Ser Ile Asp Arg Tyr
             100                 105                 110        
 Thr Phe His Ala Asn Gly Ser Leu Thr Ile Asn Lys Val Lys Leu Leu
         115                 120                 125            
 Asp Ser Gly Glu Tyr Val Cys Val Ala Arg Asn Pro Ser Gly Asp Asp
     130                 135                 140                
 Thr Lys Met Tyr Lys Leu Asp Val Val Ser Lys Pro Pro Leu Ile Asn
 145                 150                 155                 160
 Gly Leu Tyr Thr Asn Arg Thr Val Ile Lys Ala Thr Ala Val Arg His
                 165                 170                 175    
 Ser Lys Lys His Phe Asp Cys Arg Ala Glu Gly Thr Pro Ser Pro Glu
             180                 185                 190        
 Val Met Trp Ile Met Pro Asp Asn Ile Phe Leu Thr Ala Pro Tyr Tyr
         195                 200                 205            
 Gly Ser Arg Ile Thr Val His Lys Asn Gly Thr Leu Glu Ile Arg Asn
     210                 215                 220                
 Val Arg Leu Ser Asp Ser Ala Asp Phe Ile Cys Val Ala Arg Asn Glu
 225                 230                 235                 240
 Gly Gly Glu Ser Val Leu Val Val Gln Leu Glu Val Leu Glu Met Leu
                 245                 250                 255    
 Arg Arg Pro Thr Phe Arg Asn Pro Phe Asn Glu Lys Ile Val Ala Gln
             260                 265                 270        
 Leu Gly Lys Ser Thr Ala Leu Asn Cys Ser Val Asp Gly Asn Pro Pro
         275                 280                 285            
 Pro Glu Ile Ile Trp Ile Leu Pro Asn Gly Thr Arg Phe Ser Asn Gly
     290                 295                 300                
 Pro Gln Ser Tyr Gln Tyr Leu Ile Ala Ser Asn Gly Ser Phe Ile Ile
 305                 310                 315                 320
 Ser Lys Thr Thr Arg Glu Asp Ala Gly Lys Tyr Arg Cys Ala Ala Arg
                 325                 330                 335    
 Asn Lys Val Gly Tyr Ile Glu Lys Leu Val Ile Leu Glu Ile Gly Gln
             340                 345                 350        
 Lys Pro Val Ile Leu Thr Tyr Ala Pro Gly Thr Val Lys Gly Ile Ser
         355                 360                 365            
 Gly Glu Ser Leu Ser Leu His Cys Val Ser Asp Gly Ile Pro Lys Pro
     370                 375                 380                
 Asn Ile Lys Trp Thr Met Pro Ser Gly Tyr Val Val Asp Arg Pro Gln
 385                 390                 395                 400
 Ile Asn Gly Lys Tyr Ile Leu His Asp Asn Gly Thr Leu Val Ile Lys
                 405                 410                 415    
 Glu Ala Thr Ala Tyr Asp Arg Gly Asn Tyr Ile Cys Lys Ala Gln Asn
             420                 425                 430        
 Ser Val Gly His Thr Leu Ile Thr Val Pro Val Met Ile Val Ala Tyr
         435                 440                 445            
 Pro Pro Arg Ile Thr Asn Arg Pro Pro Arg Ser Ile Val Thr Arg Thr
     450                 455                 460                
 Gly Ala Ala Phe Gln Leu His Cys Val Ala Leu Gly Val Pro Lys Pro
 465                 470                 475                 480
 Glu Ile Thr Trp Glu Met Pro Asp His Ser Leu Leu Ser Thr Ala Ser
                 485                 490                 495    
 Lys Glu Arg Thr His Gly Ser Glu Gln Leu His Leu Gln Gly Thr Leu
             500                 505                 510        
 Val Ile Gln Asn Pro Gln Thr Ser Asp Ser Gly Ile Tyr Lys Cys Thr
         515                 520                 525            
 Ala Lys Asn Pro Leu Gly Ser Asp Tyr Ala Ala Thr Tyr Ile Gln Val
     530                 535                 540                
 Ile
 545



      <210> 813
      <211> 2428
      <212> PRT
      <213> Homo sapiens


      <400> 813
 Met Lys Asp Thr Lys Cys Ala Gly His Arg Arg Asn Ser Val Cys Gln
   1               5                  10                  15    
 Ser Gln Trp Gly Met Ala Gly Leu Arg Asn Gly Lys Asp Phe His Gly
              20                  25                  30        
 Ala Gly Thr Glu Gly Met Gly Val Ile Trp Ser Asp Val Ile Lys Cys
          35                  40                  45            
 Lys Lys Asp Arg Ser Pro Ser Ser Ala Gln Gln Cys Pro Leu Cys Met
      50                  55                  60                
 Asn Pro Arg Thr Ser Lys Gly Lys Pro Leu Ala Met Val Ser Ala Ala
  65                  70                  75                  80
 Ala Phe Gln Cys Ala Lys Pro Thr Ile Asp Ser Ser Leu Lys Ser Lys
                  85                  90                  95    
 Ser Leu Thr Ile Leu Glu Asp Ser Ser Ser Ala Phe Ile Ser Pro Gln
             100                 105                 110        
 Gly Phe Met Ala Pro Phe Gly Ser Leu Thr Leu Asn Met Thr Asp Gln
         115                 120                 125            
 Ser Gly Asn Glu Ala Asn Met Val Cys Ser Ile Gln Lys Pro Ser Arg
     130                 135                 140                
 Thr Ser Pro Ile Ala Phe Thr Glu Glu Asn Asp Tyr Ile Val Leu Asn
 145                 150                 155                 160
 Thr Ser Phe Ser Thr Phe Leu Val Cys Asn Ile Asp Tyr Gly His Ile
                 165                 170                 175    
 Gln Pro Val Trp Gln Ile Leu Ala Leu Tyr Ser Asp Ser Pro Leu Ile
             180                 185                 190        
 Leu Glu Arg Ser His Leu Leu Ser Glu Thr Pro Gln Leu Tyr Tyr Lys
         195                 200                 205            
 Tyr Lys Gln Val Ala Pro Lys Pro Glu Asp Ile Phe Thr Asn Ile Glu
     210                 215                 220                
 Ala Asp Leu Arg Ala Asp Pro Ser Trp Leu Met Gln Asp Gln Ile Ser
 225                 230                 235                 240
 Leu Gln Leu Asn Arg Thr Ala Thr Thr Phe Ser Thr Leu Gln Ile Gln
                 245                 250                 255    
 Tyr Ser Ser Asp Ala Gln Ile Thr Leu Pro Arg Ala Glu Met Arg Pro
             260                 265                 270        
 Val Lys His Lys Trp Thr Met Ile Ser Arg Asp Asn Asn Thr Lys Leu
         275                 280                 285            
 Glu His Thr Val Leu Val Gly Gly Thr Val Gly Leu Asn Cys Pro Gly
     290                 295                 300                
 Gln Gly Asp Pro Thr Pro His Val Asp Trp Leu Leu Ala Asp Gly Ser
 305                 310                 315                 320
 Lys Val Arg Ala Pro Tyr Val Ser Glu Asp Gly Arg Ile Leu Ile Asp
                 325                 330                 335    
 Lys Ser Gly Lys Leu Glu Leu Gln Met Ala Asp Ser Phe Asp Thr Gly
             340                 345                 350        
 Val Tyr His Cys Ile Ser Ser Asn Tyr Asp Asp Ala Asp Ile Leu Thr
         355                 360                 365            
 Tyr Arg Ile Thr Val Val Glu Pro Leu Val Glu Ala Tyr Gln Glu Asn
     370                 375                 380                
 Gly Ile His His Thr Val Phe Ile Gly Glu Thr Leu Asp Leu Pro Cys
 385                 390                 395                 400
 His Ser Thr Gly Ile Pro Asp Ala Ser Ile Ser Trp Val Ile Pro Gly
                 405                 410                 415    
 Asn Asn Val Leu Tyr Gln Ser Ser Arg Asp Lys Lys Val Leu Asn Asn
             420                 425                 430        
 Gly Thr Leu Arg Ile Leu Gln Val Thr Pro Lys Asp Gln Gly Tyr Tyr
         435                 440                 445            
 Arg Cys Val Ala Ala Asn Pro Ser Gly Val Asp Phe Leu Ile Phe Gln
     450                 455                 460                
 Val Ser Val Lys Met Lys Gly Gln Arg Pro Leu Glu His Asp Gly Glu
 465                 470                 475                 480
 Thr Glu Gly Ser Gly Leu Asp Glu Ser Asn Pro Ile Ala His Leu Lys
                 485                 490                 495    
 Glu Pro Pro Gly Ala Gln Leu Arg Thr Ser Ala Leu Met Glu Ala Glu
             500                 505                 510        
 Val Gly Lys His Thr Ser Ser Thr Ser Lys Arg His Asn Tyr Arg Glu
         515                 520                 525            
 Leu Thr Leu Gln Arg Arg Gly Asp Ser Thr His Arg Arg Phe Arg Glu
     530                 535                 540                
 Asn Arg Arg His Phe Pro Pro Ser Ala Arg Arg Ile Asp Pro Gln His
 545                 550                 555                 560
 Trp Ala Ala Leu Leu Glu Lys Ala Lys Lys Asn Ala Met Pro Asp Lys
                 565                 570                 575    
 Arg Glu Asn Thr Thr Val Ser Pro Pro Pro Val Val Thr Gln Leu Pro
             580                 585                 590        
 Asn Ile Pro Gly Glu Glu Asp Asp Ser Ser Gly Met Leu Ala Leu His
         595                 600                 605            
 Glu Glu Phe Met Val Pro Ala Thr Lys Ala Leu Asn Leu Pro Ala Arg
     610                 615                 620                
 Thr Val Thr Ala Asp Ser Arg Thr Ile Ser Asp Ser Pro Met Thr Asn
 625                 630                 635                 640
 Ile Asn Tyr Gly Thr Glu Phe Ser Pro Val Val Asn Ser Gln Ile Leu
                 645                 650                 655    
 Pro Pro Glu Glu Pro Thr Asp Phe Lys Leu Ser Thr Ala Ile Lys Thr
             660                 665                 670        
 Thr Ala Met Ser Lys Asn Ile Asn Pro Thr Met Ser Ser Gln Ile Gln
         675                 680                 685            
 Gly Thr Thr Asn Gln His Ser Ser Thr Val Phe Pro Leu Leu Leu Gly
     690                 695                 700                
 Ala Thr Glu Phe Gln Asp Ser Asp Gln Met Gly Arg Gly Arg Glu His
 705                 710                 715                 720
 Phe Gln Ser Arg Pro Pro Ile Thr Val Arg Thr Met Ile Lys Asp Val
                 725                 730                 735    
 Asn Val Lys Met Leu Ser Ser Thr Thr Asn Lys Leu Leu Leu Glu Ser
             740                 745                 750        
 Val Asn Thr Thr Asn Ser His Gln Thr Ser Val Arg Glu Val Ser Glu
         755                 760                 765            
 Pro Arg His Asn His Phe Tyr Ser His Thr Thr Gln Ile Leu Ser Thr
     770                 775                 780                
 Ser Thr Phe Pro Ser Asp Pro His Thr Ala Ala His Ser Gln Phe Pro
 785                 790                 795                 800
 Ile Pro Arg Asn Ser Thr Val Asn Ile Pro Leu Phe Arg Arg Phe Gly
                 805                 810                 815    
 Arg Gln Arg Lys Ile Gly Gly Arg Gly Arg Ile Ile Ser Pro Tyr Arg
             820                 825                 830        
 Thr Pro Val Leu Arg Arg His Arg Tyr Ser Ile Phe Arg Ser Thr Thr
         835                 840                 845            
 Arg Gly Ser Ser Glu Lys Ser Thr Thr Ala Phe Ser Ala Thr Val Leu
     850                 855                 860                
 Asn Val Thr Cys Leu Ser Cys Leu Pro Arg Glu Arg Leu Thr Thr Ala
 865                 870                 875                 880
 Thr Ala Ala Leu Ser Phe Pro Ser Ala Ala Pro Ile Thr Phe Pro Lys
                 885                 890                 895    
 Ala Asp Ile Ala Arg Val Pro Ser Glu Glu Ser Thr Thr Leu Val Gln
             900                 905                 910        
 Asn Pro Leu Leu Leu Leu Glu Asn Lys Pro Ser Val Glu Lys Thr Thr
         915                 920                 925            
 Pro Thr Ile Lys Tyr Phe Arg Thr Glu Ile Ser Gln Val Thr Pro Thr
     930                 935                 940                
 Gly Ala Val Met Thr Tyr Ala Pro Thr Ser Ile Pro Met Glu Lys Thr
 945                 950                 955                 960
 His Lys Val Asn Ala Ser Tyr Pro Arg Val Ser Ser Thr Asn Glu Ala
                 965                 970                 975    
 Lys Arg Asp Ser Val Ile Thr Ser Ser Leu Ser Gly Ala Ile Thr Lys
             980                 985                 990        
 Pro Pro Met Thr Ile Ile Ala Ile Thr Arg Phe Ser Arg Arg Lys Ile
         995                1000                1005            
 Pro Trp Gln Gln Asn Phe Val Asn Asn His Asn Pro Lys Gly Arg Leu
    1010                1015                1020                
 Arg Asn Gln His Lys Val Ser Leu Gln Lys Ser Thr Ala Val Met Leu
1025                1030                1035                1040
 Pro Lys Thr Ser Pro Ala Leu Pro Arg Asp Lys Val Ser Pro Phe His
                1045                1050                1055    
 Phe Thr Thr Leu Ser Thr Ser Val Met Gln Ile Pro Ser Asn Thr Leu
            1060                1065                1070        
 Thr Thr Ala His His Thr Thr Thr Lys Thr His Asn Pro Gly Ser Leu
        1075                1080                1085            
 Pro Thr Lys Lys Glu Leu Pro Phe Pro Pro Leu Asn Pro Met Leu Pro
    1090                1095                1100                
 Ser Ile Ile Ser Lys Asp Ser Ser Thr Lys Ser Ile Ile Ser Thr Gln
1105                1110                1115                1120
 Thr Ala Ile Pro Ala Thr Thr Pro Thr Phe Pro Ala Ser Val Ile Thr
                1125                1130                1135    
 Tyr Glu Thr Gln Thr Glu Arg Ser Arg Ala Gln Thr Ile Gln Arg Glu
            1140                1145                1150        
 Gln Glu Pro Gln Lys Lys Asn Arg Thr Asp Pro Asn Ile Ser Pro Asp
        1155                1160                1165            
 Gln Ser Ser Gly Phe Thr Thr Pro Thr Ala Met Thr Pro Pro Val Leu
    1170                1175                1180                
 Thr Thr Ala Glu Thr Ser Val Lys Pro Ser Val Ser Ala Phe Thr His
1185                1190                1195                1200
 Ser Pro Pro Glu Asn Thr Thr Gly Ile Ser Ser Thr Ile Ser Phe His
                1205                1210                1215    
 Ser Arg Thr Leu Asn Leu Thr Asp Val Ile Glu Glu Leu Ala Gln Ala
            1220                1225                1230        
 Ser Thr Gln Thr Leu Lys Ser Thr Ile Ala Ser Glu Thr Thr Leu Ser
        1235                1240                1245            
 Ser Lys Ser His Gln Ser Thr Thr Thr Arg Lys Ala Ile Ile Arg His
    1250                1255                1260                
 Ser Thr Ile Pro Pro Phe Leu Ser Ser Ser Ala Thr Leu Met Pro Val
1265                1270                1275                1280
 Pro Ile Ser Pro Pro Phe Thr Gln Arg Ala Val Thr Asp Asn Val Ala
                1285                1290                1295    
 Thr Pro Ile Ser Gly Leu Met Thr Asn Thr Val Val Lys Leu His Glu
            1300                1305                1310        
 Ser Ser Arg His Asn Ala Lys Pro Gln Gln Leu Val Ala Glu Val Ala
        1315                1320                1325            
 Thr Ser Pro Lys Val His Pro Asn Ala Lys Phe Thr Ile Gly Thr Thr
    1330                1335                1340                
 His Phe Ile Tyr Ser Asn Leu Leu His Ser Thr Pro Met Pro Ala Leu
1345                1350                1355                1360
 Thr Thr Val Lys Ser Gln Asn Ser Lys Leu Thr Pro Ser Pro Trp Ala
                1365                1370                1375    
 Glu Asn Gln Phe Trp His Lys Pro Tyr Ser Glu Ile Ala Glu Lys Gly
            1380                1385                1390        
 Lys Lys Pro Glu Val Ser Met Leu Ala Thr Thr Gly Leu Ser Glu Ala
        1395                1400                1405            
 Thr Thr Leu Val Ser Asp Trp Asp Gly Gln Lys Asn Thr Lys Lys Ser
    1410                1415                1420                
 Asp Phe Asp Lys Lys Pro Val Gln Glu Ala Thr Thr Ser Lys Leu Leu
1425                1430                1435                1440
 Pro Phe Asp Ser Leu Ser Arg Tyr Ile Phe Glu Lys Pro Arg Ile Val
                1445                1450                1455    
 Gly Gly Lys Ala Ala Ser Phe Thr Ile Pro Ala Asn Ser Asp Ala Phe
            1460                1465                1470        
 Leu Pro Cys Glu Ala Val Gly Asn Pro Leu Pro Thr Ile His Trp Thr
        1475                1480                1485            
 Arg Val Pro Ser Gly Leu Asp Leu Ser Lys Arg Lys Gln Asn Ser Arg
    1490                1495                1500                
 Val Gln Val Leu Pro Asn Gly Thr Leu Ser Ile Gln Arg Val Glu Ile
1505                1510                1515                1520
 Gln Asp Arg Gly Gln Tyr Leu Cys Ser Ala Ser Asn Leu Phe Gly Thr
                1525                1530                1535    
 Asp His Leu His Val Thr Leu Ser Val Val Ser Tyr Pro Pro Arg Ile
            1540                1545                1550        
 Leu Glu Arg Arg Thr Lys Glu Ile Thr Val His Ser Gly Ser Thr Val
        1555                1560                1565            
 Glu Leu Lys Cys Arg Ala Glu Gly Arg Pro Ser Pro Thr Val Thr Trp
    1570                1575                1580                
 Ile Leu Ala Asn Gln Thr Val Val Ser Glu Ser Ser Gln Gly Ser Arg
1585                1590                1595                1600
 Gln Ala Val Val Thr Val Asp Gly Thr Leu Val Leu His Asn Leu Ser
                1605                1610                1615    
 Ile Tyr Asp Arg Gly Phe Tyr Lys Cys Val Ala Ser Asn Pro Gly Gly
            1620                1625                1630        
 Gln Asp Ser Leu Leu Val Lys Ile Gln Val Ile Ala Ala Pro Pro Val
        1635                1640                1645            
 Ile Leu Glu Gln Arg Arg Gln Val Ile Val Gly Thr Trp Gly Glu Ser
    1650                1655                1660                
 Leu Lys Leu Pro Cys Thr Ala Lys Gly Thr Pro Gln Pro Ser Val Tyr
1665                1670                1675                1680
 Trp Val Leu Ser Asp Gly Thr Glu Val Lys Pro Leu Gln Phe Thr Asn
                1685                1690                1695    
 Ser Lys Leu Phe Leu Phe Ser Asn Gly Thr Leu Tyr Ile Arg Asn Leu
            1700                1705                1710        
 Ala Ser Ser Asp Arg Gly Thr Tyr Glu Cys Ile Ala Thr Ser Ser Thr
        1715                1720                1725            
 Gly Ser Glu Arg Arg Val Val Met Leu Thr Met Glu Glu Arg Val Thr
    1730                1735                1740                
 Ser Pro Arg Ile Glu Ala Ala Ser Gln Lys Arg Thr Glu Val Asn Phe
1745                1750                1755                1760
 Gly Asp Lys Leu Leu Leu Asn Cys Ser Ala Thr Gly Glu Pro Lys Pro
                1765                1770                1775    
 Gln Ile Met Trp Arg Leu Pro Ser Lys Ala Val Val Asp Gln Gln His
            1780                1785                1790        
 Arg Val Gly Ser Trp Ile His Val Tyr Pro Asn Gly Ser Leu Phe Ile
        1795                1800                1805            
 Gly Ser Val Thr Glu Lys Asp Ser Gly Val Tyr Leu Cys Val Ala Arg
    1810                1815                1820                
 Asn Lys Met Gly Asp Asp Leu Ile Leu Met His Val Ser Leu Arg Leu
1825                1830                1835                1840
 Lys Pro Ala Lys Ile Asp His Lys Gln Tyr Phe Arg Lys Gln Val Leu
                1845                1850                1855    
 His Gly Lys Asp Phe Gln Val Asp Cys Lys Ala Ser Gly Ser Pro Val
            1860                1865                1870        
 Pro Glu Ile Ser Trp Ser Leu Pro Asp Gly Thr Met Ile Asn Asn Ala
        1875                1880                1885            
 Met Gln Ala Asp Asp Ser Gly His Arg Thr Arg Arg Tyr Thr Leu Phe
    1890                1895                1900                
 Asn Asn Gly Thr Leu Tyr Phe Asn Lys Val Gly Val Ala Glu Glu Gly
1905                1910                1915                1920
 Asp Tyr Thr Cys Tyr Ala Gln Asn Thr Leu Gly Lys Asp Glu Met Lys
                1925                1930                1935    
 Val His Leu Thr Val Ile Thr Ala Ala Pro Arg Ile Arg Gln Ser Asn
            1940                1945                1950        
 Lys Thr Asn Lys Arg Ile Lys Ala Gly Asp Thr Ala Val Leu Asp Cys
        1955                1960                1965            
 Glu Val Thr Gly Asp Pro Lys Pro Lys Ile Phe Trp Leu Leu Pro Ser
    1970                1975                1980                
 Asn Asp Met Ile Ser Phe Ser Ile Asp Arg Tyr Thr Phe His Ala Asn
1985                1990                1995                2000
 Gly Ser Leu Thr Ile Asn Lys Val Lys Leu Leu Asp Ser Gly Glu Tyr
                2005                2010                2015    
 Val Cys Val Ala Arg Asn Pro Ser Gly Asp Asp Thr Lys Met Tyr Lys
            2020                2025                2030        
 Leu Asp Val Val Ser Lys Pro Pro Leu Ile Asn Gly Leu Tyr Thr Asn
        2035                2040                2045            
 Arg Thr Val Ile Lys Ala Thr Ala Val Arg His Ser Lys Lys His Phe
    2050                2055                2060                
 Asp Cys Arg Ala Glu Gly Thr Pro Ser Pro Glu Val Met Trp Ile Met
2065                2070                2075                2080
 Pro Asp Asn Ile Phe Leu Thr Ala Pro Tyr Tyr Gly Ser Arg Ile Thr
                2085                2090                2095    
 Val His Lys Asn Gly Thr Leu Glu Ile Arg Asn Val Arg Leu Ser Asp
            2100                2105                2110        
 Ser Ala Asp Phe Ile Cys Val Ala Arg Asn Glu Gly Gly Glu Ser Val
        2115                2120                2125            
 Leu Val Val Gln Leu Glu Val Leu Glu Met Leu Arg Arg Pro Thr Phe
    2130                2135                2140                
 Arg Asn Pro Phe Asn Glu Lys Ile Val Ala Gln Leu Gly Lys Ser Thr
2145                2150                2155                2160
 Ala Leu Asn Cys Ser Val Asp Gly Asn Pro Pro Pro Glu Ile Ile Trp
                2165                2170                2175    
 Ile Leu Pro Asn Gly Thr Arg Phe Ser Asn Gly Pro Gln Ser Tyr Gln
            2180                2185                2190        
 Tyr Leu Ile Ala Ser Asn Gly Ser Phe Ile Ile Ser Lys Thr Thr Arg
        2195                2200                2205            
 Glu Asp Ala Gly Lys Tyr Arg Cys Ala Ala Arg Asn Lys Val Gly Tyr
    2210                2215                2220                
 Ile Glu Lys Leu Val Ile Leu Glu Ile Gly Gln Lys Pro Val Ile Leu
2225                2230                2235                2240
 Thr Tyr Ala Pro Gly Thr Val Lys Gly Ile Ser Gly Glu Ser Leu Ser
                2245                2250                2255    
 Leu His Cys Val Ser Asp Gly Ile Pro Lys Pro Asn Ile Lys Trp Thr
            2260                2265                2270        
 Met Pro Ser Gly Tyr Val Val Asp Arg Pro Gln Ile Asn Gly Lys Tyr
        2275                2280                2285            
 Ile Leu His Asp Asn Gly Thr Leu Val Ile Lys Glu Ala Thr Ala Tyr
    2290                2295                2300                
 Asp Arg Gly Asn Tyr Ile Cys Lys Ala Gln Asn Ser Val Gly His Thr
2305                2310                2315                2320
 Leu Ile Thr Val Pro Val Met Ile Val Ala Tyr Pro Pro Arg Ile Thr
                2325                2330                2335    
 Asn Arg Pro Pro Arg Ser Ile Val Thr Arg Thr Gly Ala Ala Phe Gln
            2340                2345                2350        
 Leu His Cys Val Ala Leu Gly Val Pro Lys Pro Glu Ile Thr Trp Glu
        2355                2360                2365            
 Met Pro Asp His Ser Leu Leu Ser Thr Ala Ser Lys Glu Arg Thr His
    2370                2375                2380                
 Gly Ser Glu Gln Leu His Leu Gln Gly Thr Leu Val Ile Gln Asn Pro
2385                2390                2395                2400
 Gln Thr Ser Asp Ser Gly Ile Tyr Lys Cys Thr Ala Lys Asn Pro Leu
                2405                2410                2415    
 Gly Ser Asp Tyr Ala Ala Thr Tyr Ile Gln Val Ile
            2420                2425            



      <210> 814
      <211> 2623
      <212> PRT
      <213> Homo sapiens


      <400> 814
 Met Lys Val Lys Gly Arg Gly Ile Thr Cys Leu Leu Val Ser Phe Ala
   1               5                  10                  15    
 Val Ile Cys Leu Val Ala Thr Pro Gly Gly Lys Ala Cys Pro Arg Arg
              20                  25                  30        
 Cys Ala Cys Tyr Met Pro Thr Glu Val His Cys Thr Phe Arg Tyr Leu
          35                  40                  45            
 Thr Ser Ile Pro Asp Ser Ile Pro Pro Asn Val Glu Arg Ile Asn Leu
      50                  55                  60                
 Gly Tyr Asn Ser Leu Val Arg Leu Met Glu Thr Asp Phe Ser Gly Leu
  65                  70                  75                  80
 Thr Lys Leu Glu Leu Leu Met Leu His Ser Asn Gly Ile His Thr Ile
                  85                  90                  95    
 Pro Asp Lys Thr Phe Ser Asp Leu Gln Ala Leu Gln Val Leu Lys Met
             100                 105                 110        
 Ser Tyr Asn Lys Val Arg Lys Leu Gln Lys Asp Thr Phe Tyr Gly Leu
         115                 120                 125            
 Arg Ser Leu Thr Arg Leu His Met Asp His Asn Asn Ile Glu Phe Ile
     130                 135                 140                
 Asn Pro Glu Val Phe Tyr Gly Leu Asn Phe Leu Arg Leu Val His Leu
 145                 150                 155                 160
 Glu Gly Asn Gln Leu Thr Lys Leu His Pro Asp Thr Phe Val Ser Leu
                 165                 170                 175    
 Ser Tyr Leu Gln Ile Phe Lys Ile Ser Phe Ile Lys Phe Leu Tyr Leu
             180                 185                 190        
 Ser Asp Asn Phe Leu Thr Ser Leu Pro Gln Glu Met Val Ser Tyr Met
         195                 200                 205            
 Pro Asp Leu Asp Ser Leu Tyr Leu His Gly Asn Pro Trp Thr Cys Asp
     210                 215                 220                
 Cys His Leu Lys Trp Leu Ser Asp Trp Ile Gln Glu Lys Pro Asp Val
 225                 230                 235                 240
 Ile Lys Cys Lys Lys Asp Arg Ser Pro Ser Ser Ala Gln Gln Cys Pro
                 245                 250                 255    
 Leu Cys Met Asn Pro Arg Thr Ser Lys Gly Lys Pro Leu Ala Met Val
             260                 265                 270        
 Ser Ala Ala Ala Phe Gln Cys Ala Lys Pro Thr Ile Asp Ser Ser Leu
         275                 280                 285            
 Lys Ser Lys Ser Leu Thr Ile Leu Glu Asp Ser Ser Ser Ala Phe Ile
     290                 295                 300                
 Ser Pro Gln Gly Phe Met Ala Pro Phe Gly Ser Leu Thr Leu Asn Met
 305                 310                 315                 320
 Thr Asp Gln Ser Gly Asn Glu Ala Asn Met Val Cys Ser Ile Gln Lys
                 325                 330                 335    
 Pro Ser Arg Thr Ser Pro Ile Ala Phe Thr Glu Glu Asn Asp Tyr Ile
             340                 345                 350        
 Val Leu Asn Thr Ser Phe Ser Thr Phe Leu Val Cys Asn Ile Asp Tyr
         355                 360                 365            
 Gly His Ile Gln Pro Val Trp Gln Ile Leu Ala Leu Tyr Ser Asp Ser
     370                 375                 380                
 Pro Leu Ile Leu Glu Arg Ser His Leu Leu Ser Glu Thr Pro Gln Leu
 385                 390                 395                 400
 Tyr Tyr Lys Tyr Lys Gln Val Ala Pro Lys Pro Glu Asp Ile Phe Thr
                 405                 410                 415    
 Asn Ile Glu Ala Asp Leu Arg Ala Asp Pro Ser Trp Leu Met Gln Asp
             420                 425                 430        
 Gln Ile Ser Leu Gln Leu Asn Arg Thr Ala Thr Thr Phe Ser Thr Leu
         435                 440                 445            
 Gln Ile Gln Tyr Ser Ser Asp Ala Gln Ile Thr Leu Pro Arg Ala Glu
     450                 455                 460                
 Met Arg Pro Val Lys His Lys Trp Thr Met Ile Ser Arg Asp Asn Asn
 465                 470                 475                 480
 Thr Lys Leu Glu His Thr Val Leu Val Gly Gly Thr Val Gly Leu Asn
                 485                 490                 495    
 Cys Pro Gly Gln Gly Asp Pro Thr Pro His Val Asp Trp Leu Leu Ala
             500                 505                 510        
 Asp Gly Ser Lys Val Arg Ala Pro Tyr Val Ser Glu Asp Gly Arg Ile
         515                 520                 525            
 Leu Ile Asp Lys Ser Gly Lys Leu Glu Leu Gln Met Ala Asp Ser Phe
     530                 535                 540                
 Asp Thr Gly Val Tyr His Cys Ile Ser Ser Asn Tyr Asp Asp Ala Asp
 545                 550                 555                 560
 Ile Leu Thr Tyr Arg Ile Thr Val Val Glu Pro Leu Val Glu Ala Tyr
                 565                 570                 575    
 Gln Glu Asn Gly Ile His His Thr Val Phe Ile Gly Glu Thr Leu Asp
             580                 585                 590        
 Leu Pro Cys His Ser Thr Gly Ile Pro Asp Ala Ser Ile Ser Trp Val
         595                 600                 605            
 Ile Pro Gly Asn Asn Val Leu Tyr Gln Ser Ser Arg Asp Lys Lys Val
     610                 615                 620                
 Leu Asn Asn Gly Thr Leu Arg Ile Leu Gln Val Thr Pro Lys Asp Gln
 625                 630                 635                 640
 Gly Tyr Tyr Arg Cys Val Ala Ala Asn Pro Ser Gly Val Asp Phe Leu
                 645                 650                 655    
 Ile Phe Gln Val Ser Val Lys Met Lys Gly Gln Arg Pro Leu Glu His
             660                 665                 670        
 Asp Gly Glu Thr Glu Gly Ser Gly Leu Asp Glu Ser Asn Pro Ile Ala
         675                 680                 685            
 His Leu Lys Glu Pro Pro Gly Ala Gln Leu Arg Thr Ser Ala Leu Met
     690                 695                 700                
 Glu Ala Glu Val Gly Lys His Thr Ser Ser Thr Ser Lys Arg His Asn
 705                 710                 715                 720
 Tyr Arg Glu Leu Thr Leu Gln Arg Arg Gly Asp Ser Thr His Arg Arg
                 725                 730                 735    
 Phe Arg Glu Asn Arg Arg His Phe Pro Pro Ser Ala Arg Arg Ile Asp
             740                 745                 750        
 Pro Gln His Trp Ala Ala Leu Leu Glu Lys Ala Lys Lys Asn Ala Met
         755                 760                 765            
 Pro Asp Lys Arg Glu Asn Thr Thr Val Ser Pro Pro Pro Val Val Thr
     770                 775                 780                
 Gln Leu Pro Asn Ile Pro Gly Glu Glu Asp Asp Ser Ser Gly Met Leu
 785                 790                 795                 800
 Ala Leu His Glu Glu Phe Met Val Pro Ala Thr Lys Ala Leu Asn Leu
                 805                 810                 815    
 Pro Ala Arg Thr Val Thr Ala Asp Ser Arg Thr Ile Ser Asp Ser Pro
             820                 825                 830        
 Met Thr Asn Ile Asn Tyr Gly Thr Glu Phe Ser Pro Val Val Asn Ser
         835                 840                 845            
 Gln Ile Leu Pro Pro Glu Glu Pro Thr Asp Phe Lys Leu Ser Thr Ala
     850                 855                 860                
 Ile Lys Thr Thr Ala Met Ser Lys Asn Ile Asn Pro Thr Met Ser Ser
 865                 870                 875                 880
 Gln Ile Gln Gly Thr Thr Asn Gln His Ser Ser Thr Val Phe Pro Leu
                 885                 890                 895    
 Leu Leu Gly Ala Thr Glu Phe Gln Asp Ser Asp Gln Met Gly Arg Gly
             900                 905                 910        
 Arg Glu His Phe Gln Ser Arg Pro Pro Ile Thr Val Arg Thr Met Ile
         915                 920                 925            
 Lys Asp Val Asn Val Lys Met Leu Ser Ser Thr Thr Asn Lys Leu Leu
     930                 935                 940                
 Leu Glu Ser Val Asn Thr Thr Asn Ser His Gln Thr Ser Val Arg Glu
 945                 950                 955                 960
 Val Ser Glu Pro Arg His Asn His Phe Tyr Ser His Thr Thr Gln Ile
                 965                 970                 975    
 Leu Ser Thr Ser Thr Phe Pro Ser Asp Pro His Thr Ala Ala His Ser
             980                 985                 990        
 Gln Phe Pro Ile Pro Arg Asn Ser Thr Val Asn Ile Pro Leu Phe Arg
         995                1000                1005            
 Arg Phe Gly Arg Gln Arg Lys Ile Gly Gly Arg Gly Arg Ile Ile Ser
    1010                1015                1020                
 Pro Tyr Arg Thr Pro Val Leu Arg Arg His Arg Tyr Ser Ile Phe Arg
1025                1030                1035                1040
 Ser Thr Thr Arg Gly Ser Ser Glu Lys Ser Thr Thr Ala Phe Ser Ala
                1045                1050                1055    
 Thr Val Leu Asn Val Thr Cys Leu Ser Cys Leu Pro Arg Glu Arg Leu
            1060                1065                1070        
 Thr Thr Ala Thr Ala Ala Leu Ser Phe Pro Ser Ala Ala Pro Ile Thr
        1075                1080                1085            
 Phe Pro Lys Ala Asp Ile Ala Arg Val Pro Ser Glu Glu Ser Thr Thr
    1090                1095                1100                
 Leu Val Gln Asn Pro Leu Leu Leu Leu Glu Asn Lys Pro Ser Val Glu
1105                1110                1115                1120
 Lys Thr Thr Pro Thr Ile Lys Tyr Phe Arg Thr Glu Ile Ser Gln Val
                1125                1130                1135    
 Thr Pro Thr Gly Ala Val Met Thr Tyr Ala Pro Thr Ser Ile Pro Met
            1140                1145                1150        
 Glu Lys Thr His Lys Val Asn Ala Ser Tyr Pro Arg Val Ser Ser Thr
        1155                1160                1165            
 Asn Glu Ala Lys Arg Asp Ser Val Ile Thr Ser Ser Leu Ser Gly Ala
    1170                1175                1180                
 Ile Thr Lys Pro Pro Met Thr Ile Ile Ala Ile Thr Arg Phe Ser Arg
1185                1190                1195                1200
 Arg Lys Ile Pro Trp Gln Gln Asn Phe Val Asn Asn His Asn Pro Lys
                1205                1210                1215    
 Gly Arg Leu Arg Asn Gln His Lys Val Ser Leu Gln Lys Ser Thr Ala
            1220                1225                1230        
 Val Met Leu Pro Lys Thr Ser Pro Ala Leu Pro Arg Asp Lys Val Ser
        1235                1240                1245            
 Pro Phe His Phe Thr Thr Leu Ser Thr Ser Val Met Gln Ile Pro Ser
    1250                1255                1260                
 Asn Thr Leu Thr Thr Ala His His Thr Thr Thr Lys Thr His Asn Pro
1265                1270                1275                1280
 Gly Ser Leu Pro Thr Lys Lys Glu Leu Pro Phe Pro Pro Leu Asn Pro
                1285                1290                1295    
 Met Leu Pro Ser Ile Ile Ser Lys Asp Ser Ser Thr Lys Ser Ile Ile
            1300                1305                1310        
 Ser Thr Gln Thr Ala Ile Pro Ala Thr Thr Pro Thr Phe Pro Ala Ser
        1315                1320                1325            
 Val Ile Thr Tyr Glu Thr Gln Thr Glu Arg Ser Arg Ala Gln Thr Ile
    1330                1335                1340                
 Gln Arg Glu Gln Glu Pro Gln Lys Lys Asn Arg Thr Asp Pro Asn Ile
1345                1350                1355                1360
 Ser Pro Asp Gln Ser Ser Gly Phe Thr Thr Pro Thr Ala Met Thr Pro
                1365                1370                1375    
 Pro Val Leu Thr Thr Ala Glu Thr Ser Val Lys Pro Ser Val Ser Ala
            1380                1385                1390        
 Phe Thr His Ser Pro Pro Glu Asn Thr Thr Gly Ile Ser Ser Thr Ile
        1395                1400                1405            
 Ser Phe His Ser Arg Thr Leu Asn Leu Thr Asp Val Ile Glu Glu Leu
    1410                1415                1420                
 Ala Gln Ala Ser Thr Gln Thr Leu Lys Ser Thr Ile Ala Ser Glu Thr
1425                1430                1435                1440
 Thr Leu Ser Ser Lys Ser His Gln Ser Thr Thr Thr Arg Lys Ala Ile
                1445                1450                1455    
 Ile Arg His Ser Thr Ile Pro Pro Phe Leu Ser Ser Ser Ala Thr Leu
            1460                1465                1470        
 Met Pro Val Pro Ile Ser Pro Pro Phe Thr Gln Arg Ala Val Thr Asp
        1475                1480                1485            
 Asn Val Ala Thr Pro Ile Ser Gly Leu Met Thr Asn Thr Val Val Lys
    1490                1495                1500                
 Leu His Glu Ser Ser Arg His Asn Ala Lys Pro Gln Gln Leu Val Ala
1505                1510                1515                1520
 Glu Val Ala Thr Ser Pro Lys Val His Pro Asn Ala Lys Phe Thr Ile
                1525                1530                1535    
 Gly Thr Thr His Phe Ile Tyr Ser Asn Leu Leu His Ser Thr Pro Met
            1540                1545                1550        
 Pro Ala Leu Thr Thr Val Lys Ser Gln Asn Ser Lys Leu Thr Pro Ser
        1555                1560                1565            
 Pro Trp Ala Glu Asn Gln Phe Trp His Lys Pro Tyr Ser Glu Ile Ala
    1570                1575                1580                
 Glu Lys Gly Lys Lys Pro Glu Val Ser Met Leu Ala Thr Thr Gly Leu
1585                1590                1595                1600
 Ser Glu Ala Thr Thr Leu Val Ser Asp Trp Asp Gly Gln Lys Asn Thr
                1605                1610                1615    
 Lys Lys Ser Asp Phe Asp Lys Lys Pro Val Gln Glu Ala Thr Thr Ser
            1620                1625                1630        
 Lys Leu Leu Pro Phe Asp Ser Leu Ser Arg Tyr Ile Phe Glu Lys Pro
        1635                1640                1645            
 Arg Ile Val Gly Gly Lys Ala Ala Ser Phe Thr Ile Pro Ala Asn Ser
    1650                1655                1660                
 Asp Ala Phe Leu Pro Cys Glu Ala Val Gly Asn Pro Leu Pro Thr Ile
1665                1670                1675                1680
 His Trp Thr Arg Val Pro Ser Gly Leu Asp Leu Ser Lys Arg Lys Gln
                1685                1690                1695    
 Asn Ser Arg Val Gln Val Leu Pro Asn Gly Thr Leu Ser Ile Gln Arg
            1700                1705                1710        
 Val Glu Ile Gln Asp Arg Gly Gln Tyr Leu Cys Ser Ala Ser Asn Leu
        1715                1720                1725            
 Phe Gly Thr Asp His Leu His Val Thr Leu Ser Val Val Ser Tyr Pro
    1730                1735                1740                
 Pro Arg Ile Leu Glu Arg Arg Thr Lys Glu Ile Thr Val His Ser Gly
1745                1750                1755                1760
 Ser Thr Val Glu Leu Lys Cys Arg Ala Glu Gly Arg Pro Ser Pro Thr
                1765                1770                1775    
 Val Thr Trp Ile Leu Ala Asn Gln Thr Val Val Ser Glu Ser Ser Gln
            1780                1785                1790        
 Gly Ser Arg Gln Ala Val Val Thr Val Asp Gly Thr Leu Val Leu His
        1795                1800                1805            
 Asn Leu Ser Ile Tyr Asp Arg Gly Phe Tyr Lys Cys Val Ala Ser Asn
    1810                1815                1820                
 Pro Gly Gly Gln Asp Ser Leu Leu Val Lys Ile Gln Val Ile Ala Ala
1825                1830                1835                1840
 Pro Pro Val Ile Leu Glu Gln Arg Arg Gln Val Ile Val Gly Thr Trp
                1845                1850                1855    
 Gly Glu Ser Leu Lys Leu Pro Cys Thr Ala Lys Gly Thr Pro Gln Pro
            1860                1865                1870        
 Ser Val Tyr Trp Val Leu Ser Asp Gly Thr Glu Val Lys Pro Leu Gln
        1875                1880                1885            
 Phe Thr Asn Ser Lys Leu Phe Leu Phe Ser Asn Gly Thr Leu Tyr Ile
    1890                1895                1900                
 Arg Asn Leu Ala Ser Ser Asp Arg Gly Thr Tyr Glu Cys Ile Ala Thr
1905                1910                1915                1920
 Ser Ser Thr Gly Ser Glu Arg Arg Val Val Met Leu Thr Met Glu Glu
                1925                1930                1935    
 Arg Val Thr Ser Pro Arg Ile Glu Ala Ala Ser Gln Lys Arg Thr Glu
            1940                1945                1950        
 Val Asn Phe Gly Asp Lys Leu Leu Leu Asn Cys Ser Ala Thr Gly Glu
        1955                1960                1965            
 Pro Lys Pro Gln Ile Met Trp Arg Leu Pro Ser Lys Ala Val Val Asp
    1970                1975                1980                
 Gln Gln His Arg Val Gly Ser Trp Ile His Val Tyr Pro Asn Gly Ser
1985                1990                1995                2000
 Leu Phe Ile Gly Ser Val Thr Glu Lys Asp Ser Gly Val Tyr Leu Cys
                2005                2010                2015    
 Val Ala Arg Asn Lys Met Gly Asp Asp Leu Ile Leu Met His Val Ser
            2020                2025                2030        
 Leu Arg Leu Lys Pro Ala Lys Ile Asp His Lys Gln Tyr Phe Arg Lys
        2035                2040                2045            
 Gln Val Leu His Gly Lys Asp Phe Gln Val Asp Cys Lys Ala Ser Gly
    2050                2055                2060                
 Ser Pro Val Pro Glu Ile Ser Trp Ser Leu Pro Asp Gly Thr Met Ile
2065                2070                2075                2080
 Asn Asn Ala Met Gln Ala Asp Asp Ser Gly His Arg Thr Arg Arg Tyr
                2085                2090                2095    
 Thr Leu Phe Asn Asn Gly Thr Leu Tyr Phe Asn Lys Val Gly Val Ala
            2100                2105                2110        
 Glu Glu Gly Asp Tyr Thr Cys Tyr Ala Gln Asn Thr Leu Gly Lys Asp
        2115                2120                2125            
 Glu Met Lys Val His Leu Thr Val Ile Thr Ala Ala Pro Arg Ile Arg
    2130                2135                2140                
 Gln Ser Asn Lys Thr Asn Lys Arg Ile Lys Ala Gly Asp Thr Ala Val
2145                2150                2155                2160
 Leu Asp Cys Glu Val Thr Gly Asp Pro Lys Pro Lys Ile Phe Trp Leu
                2165                2170                2175    
 Leu Pro Ser Asn Asp Met Ile Ser Phe Ser Ile Asp Arg Tyr Thr Phe
            2180                2185                2190        
 His Ala Asn Gly Ser Leu Thr Ile Asn Lys Val Lys Leu Leu Asp Ser
        2195                2200                2205            
 Gly Glu Tyr Val Cys Val Ala Arg Asn Pro Ser Gly Asp Asp Thr Lys
    2210                2215                2220                
 Met Tyr Lys Leu Asp Val Val Ser Lys Pro Pro Leu Ile Asn Gly Leu
2225                2230                2235                2240
 Tyr Thr Asn Arg Thr Val Ile Lys Ala Thr Ala Val Arg His Ser Lys
                2245                2250                2255    
 Lys His Phe Asp Cys Arg Ala Glu Gly Thr Pro Ser Pro Glu Val Met
            2260                2265                2270        
 Trp Ile Met Pro Asp Asn Ile Phe Leu Thr Ala Pro Tyr Tyr Gly Ser
        2275                2280                2285            
 Arg Ile Thr Val His Lys Asn Gly Thr Leu Glu Ile Arg Asn Val Arg
    2290                2295                2300                
 Leu Ser Asp Ser Ala Asp Phe Ile Cys Val Ala Arg Asn Glu Gly Gly
2305                2310                2315                2320
 Glu Ser Val Leu Val Val Gln Leu Glu Val Leu Glu Met Leu Arg Arg
                2325                2330                2335    
 Pro Thr Phe Arg Asn Pro Phe Asn Glu Lys Ile Val Ala Gln Leu Gly
            2340                2345                2350        
 Lys Ser Thr Ala Leu Asn Cys Ser Val Asp Gly Asn Pro Pro Pro Glu
        2355                2360                2365            
 Ile Ile Trp Ile Leu Pro Asn Gly Thr Arg Phe Ser Asn Gly Pro Gln
    2370                2375                2380                
 Ser Tyr Gln Tyr Leu Ile Ala Ser Asn Gly Ser Phe Ile Ile Ser Lys
2385                2390                2395                2400
 Thr Thr Arg Glu Asp Ala Gly Lys Tyr Arg Cys Ala Ala Arg Asn Lys
                2405                2410                2415    
 Val Gly Tyr Ile Glu Lys Leu Val Ile Leu Glu Ile Gly Gln Lys Pro
            2420                2425                2430        
 Val Ile Leu Thr Tyr Ala Pro Gly Thr Val Lys Gly Ile Ser Gly Glu
        2435                2440                2445            
 Ser Leu Ser Leu His Cys Val Ser Asp Gly Ile Pro Lys Pro Asn Ile
    2450                2455                2460                
 Lys Trp Thr Met Pro Ser Gly Tyr Val Val Asp Arg Pro Gln Ile Asn
2465                2470                2475                2480
 Gly Lys Tyr Ile Leu His Asp Asn Gly Thr Leu Val Ile Lys Glu Ala
                2485                2490                2495    
 Thr Ala Tyr Asp Arg Gly Asn Tyr Ile Cys Lys Ala Gln Asn Ser Val
            2500                2505                2510        
 Gly His Thr Leu Ile Thr Val Pro Val Met Ile Val Ala Tyr Pro Pro
        2515                2520                2525            
 Arg Ile Thr Asn Arg Pro Pro Arg Ser Ile Val Thr Arg Thr Gly Ala
    2530                2535                2540                
 Ala Phe Gln Leu His Cys Val Ala Leu Gly Val Pro Lys Pro Glu Ile
2545                2550                2555                2560
 Thr Trp Glu Met Pro Asp His Ser Leu Leu Ser Thr Ala Ser Lys Glu
                2565                2570                2575    
 Arg Thr His Gly Ser Glu Gln Leu His Leu Gln Gly Thr Leu Val Ile
            2580                2585                2590        
 Gln Asn Pro Gln Thr Ser Asp Ser Gly Ile Tyr Lys Cys Thr Ala Lys
        2595                2600                2605            
 Asn Pro Leu Gly Ser Asp Tyr Ala Ala Thr Tyr Ile Gln Val Ile
    2610                2615                2620            



      <210> 815
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 815
 Met Met Ile Trp Ile His Gln Asp Leu Phe Tyr Ala Gln Gly Gln Phe
   1               5                  10                  15    
 Leu Phe Ser Phe Phe Phe Phe Phe Phe Phe Phe Phe Glu Thr Gly Ser
              20                  25                  30        
 Arg Phe Val Ala Gln Ala Gly Val Glu Trp Arg Asp Leu Gly Leu Leu
          35                  40                  45            
 Gln Pro Leu Pro Pro Arg Leu Glu Gln Ser Cys Leu Ser Leu Arg Ser
      50                  55                  60                
 Ser Trp Asp His Arg Phe Met Pro Pro Trp Pro Ala Asn Phe Cys Met
  65                  70                  75                  80
 Phe Cys Arg Asp Gly Val Ser Gln Cys Cys Pro Gly Trp Ser Gln Thr
                  85                  90                  95    
 Pro Gly Leu Arg Arg Ser Thr Cys Leu Ser Leu Pro Glu Cys Trp Asp
             100                 105                 110        
 Tyr Asn Cys Glu Pro Pro Arg Pro Ala Gly Arg Val Asn Ile Phe Tyr
         115                 120                 125            
 Ile Leu Gln Ala His Leu His Phe His Pro Thr Leu Pro Leu Leu Leu
     130                 135                 140                
 Pro Phe Tyr Ile Pro Phe Leu Tyr Arg Ser Leu Ile Leu Gln
 145                 150                 155            



      <210> 816
      <211> 366
      <212> PRT
      <213> Homo sapiens


      <400> 816
 Met Ala Ser Met Ala Ala Val Leu Thr Trp Ala Leu Ala Leu Leu Ser
   1               5                  10                  15    
 Ala Phe Ser Ala Thr Gln Ala Arg Lys Gly Phe Trp Asp Tyr Phe Ser
              20                  25                  30        
 Gln Thr Ser Gly Asp Lys Gly Arg Val Glu Gln Ile His Gln Gln Lys
          35                  40                  45            
 Met Ala Arg Glu Pro Ala Thr Leu Lys Asp Ser Leu Glu Gln Asp Leu
      50                  55                  60                
 Asn Asn Met Asn Lys Phe Leu Glu Lys Leu Arg Pro Leu Ser Gly Ser
  65                  70                  75                  80
 Glu Ala Pro Arg Leu Pro Gln Asp Pro Val Gly Met Arg Arg Gln Leu
                  85                  90                  95    
 Gln Glu Glu Leu Glu Glu Val Lys Ala Arg Leu Gln Pro Tyr Met Ala
             100                 105                 110        
 Glu Ala His Glu Leu Val Gly Trp Asn Leu Glu Gly Leu Arg Gln Gln
         115                 120                 125            
 Leu Lys Pro Tyr Thr Met Asp Leu Met Glu Gln Val Ala Leu Arg Val
     130                 135                 140                
 Gln Glu Leu Gln Glu Gln Leu Arg Val Val Gly Glu Asp Thr Lys Ala
 145                 150                 155                 160
 Gln Leu Leu Gly Gly Val Asp Glu Ala Trp Ala Leu Leu Gln Gly Leu
                 165                 170                 175    
 Gln Ser Arg Val Val His His Thr Gly Arg Phe Lys Glu Leu Phe His
             180                 185                 190        
 Pro Tyr Ala Glu Ser Leu Val Ser Gly Ile Gly Arg His Val Gln Glu
         195                 200                 205            
 Leu His Arg Ser Val Ala Pro His Ala Pro Ala Ser Pro Ala Arg Leu
     210                 215                 220                
 Ser Arg Cys Val Gln Val Leu Ser Arg Lys Leu Thr Leu Lys Ala Lys
 225                 230                 235                 240
 Ala Leu His Ala Arg Ile Gln Gln Asn Leu Asp Gln Leu Arg Glu Glu
                 245                 250                 255    
 Leu Ser Arg Ala Phe Ala Gly Thr Gly Thr Glu Glu Gly Ala Gly Pro
             260                 265                 270        
 Asp Pro Gln Met Leu Ser Glu Glu Val Arg Gln Arg Leu Gln Ala Phe
         275                 280                 285            
 Arg Gln Asp Thr Tyr Leu Gln Ile Ala Ala Phe Thr Arg Ala Ile Asp
     290                 295                 300                
 Gln Glu Thr Glu Glu Val Gln Gln Gln Leu Ala Pro Pro Pro Pro Gly
 305                 310                 315                 320
 His Ser Ala Phe Ala Pro Glu Phe Gln Gln Thr Asp Ser Gly Lys Val
                 325                 330                 335    
 Leu Ser Lys Leu Gln Ala Arg Leu Asp Asp Leu Trp Glu Asp Ile Thr
             340                 345                 350        
 His Ser Leu His Asp Gln Gly His Ser His Leu Gly Asp Pro
         355                 360                 365    



      <210> 817
      <211> 366
      <212> PRT
      <213> Homo sapiens


      <400> 817
 Met Ala Ser Met Ala Ala Val Leu Thr Trp Ala Leu Ala Leu Leu Ser
   1               5                  10                  15    
 Ala Phe Ser Ala Thr Gln Ala Arg Lys Gly Phe Trp Asp Tyr Phe Ser
              20                  25                  30        
 Gln Thr Ser Gly Asp Lys Gly Arg Val Glu Gln Ile His Gln Gln Lys
          35                  40                  45            
 Met Ala Arg Glu Pro Ala Thr Leu Lys Asp Ser Leu Glu Gln Asp Leu
      50                  55                  60                
 Asn Asn Met Asn Lys Phe Leu Glu Lys Leu Arg Pro Leu Ser Gly Ser
  65                  70                  75                  80
 Glu Ala Pro Arg Leu Pro Gln Asp Pro Val Gly Met Arg Arg Gln Leu
                  85                  90                  95    
 Gln Glu Glu Leu Glu Glu Val Lys Ala Arg Leu Gln Pro Tyr Met Ala
             100                 105                 110        
 Glu Ala His Glu Leu Val Gly Trp Asn Leu Glu Gly Leu Arg Gln Gln
         115                 120                 125            
 Leu Lys Pro Tyr Thr Met Asp Leu Met Glu Gln Val Ala Leu Arg Val
     130                 135                 140                
 Gln Glu Leu Gln Glu Gln Leu Arg Val Val Gly Glu Asp Thr Lys Ala
 145                 150                 155                 160
 Gln Leu Leu Gly Gly Val Asp Glu Ala Trp Ala Leu Leu Gln Gly Leu
                 165                 170                 175    
 Gln Ser Arg Val Val His His Thr Gly Arg Phe Lys Glu Leu Phe His
             180                 185                 190        
 Pro Tyr Ala Glu Ser Leu Val Ser Gly Ile Gly Arg His Val Gln Glu
         195                 200                 205            
 Leu His Arg Ser Val Ala Pro His Ala Pro Ala Ser Pro Ala Arg Leu
     210                 215                 220                
 Ser Arg Cys Val Gln Val Leu Ser Arg Lys Leu Thr Leu Lys Ala Lys
 225                 230                 235                 240
 Ala Leu His Ala Arg Ile Gln Gln Asn Leu Asp Gln Leu Arg Glu Glu
                 245                 250                 255    
 Leu Ser Arg Ala Phe Ala Gly Thr Gly Thr Glu Glu Gly Ala Gly Pro
             260                 265                 270        
 Asp Pro Gln Met Leu Ser Glu Glu Val Arg Gln Arg Leu Gln Ala Phe
         275                 280                 285            
 Arg Gln Asp Thr Tyr Leu Gln Ile Ala Ala Phe Thr Arg Ala Ile Asp
     290                 295                 300                
 Gln Glu Thr Glu Glu Val Gln Gln Gln Leu Ala Pro Pro Pro Pro Gly
 305                 310                 315                 320
 His Ser Ala Phe Ala Pro Glu Phe Gln Gln Thr Asp Ser Gly Lys Val
                 325                 330                 335    
 Leu Ser Lys Leu Gln Ala Arg Leu Asp Asp Leu Trp Glu Asp Ile Thr
             340                 345                 350        
 His Ser Leu His Asp Gln Gly His Ser His Leu Gly Asp Pro
         355                 360                 365    



      <210> 818
      <211> 331
      <212> PRT
      <213> Homo sapiens


      <400> 818
 Met Leu Ser Ser His Gly Gly Glu Ile Phe Leu His Val Leu Ser Ser
   1               5                  10                  15    
 Ser Arg Ser Ile Leu Glu Asp Pro Pro Ser Ile Ser Glu Gly Cys Gly
              20                  25                  30        
 Gly Arg Val Thr Asp Tyr Arg Ile Thr Asp Phe Gly Glu Phe Met Arg
          35                  40                  45            
 Glu Asn Arg Leu Thr Pro Phe Leu Asp Pro Arg Tyr Lys Ile Asp Gly
      50                  55                  60                
 Ser Leu Glu Val Pro Leu Glu Arg Ala Lys Asp Gln Leu Glu Lys His
  65                  70                  75                  80
 Thr Arg Tyr Trp Pro Met Ile Ile Ser Gln Thr Thr Ile Phe Asn Met
                  85                  90                  95    
 Gln Ala Val Val Pro Leu Ala Ser Val Ile Val Lys Glu Ser Leu Thr
             100                 105                 110        
 Glu Glu Asp Val Leu Asn Cys Gln Lys Thr Ile Tyr Asn Leu Val Asp
         115                 120                 125            
 Met Glu Arg Lys Asn Asp Pro Leu Pro Ile Ser Thr Val Gly Thr Arg
     130                 135                 140                
 Gly Lys Gly Pro Lys Arg Asp Glu Gln Tyr Arg Ile Met Trp Asn Glu
 145                 150                 155                 160
 Leu Glu Thr Leu Val Arg Ala His Ile Asn Asn Ser Glu Lys His Gln
                 165                 170                 175    
 Arg Val Leu Glu Cys Leu Met Ala Cys Arg Ser Lys Pro Pro Glu Glu
             180                 185                 190        
 Glu Glu Arg Lys Lys Arg Gly Arg Lys Arg Glu Asp Lys Glu Asp Lys
         195                 200                 205            
 Ser Glu Lys Ala Val Lys Asp Tyr Glu Gln Glu Lys Ser Trp Gln Asp
     210                 215                 220                
 Ser Glu Arg Leu Lys Gly Ile Leu Glu Arg Gly Lys Glu Glu Leu Ala
 225                 230                 235                 240
 Glu Ala Glu Ile Ile Lys Asp Ser Pro Asp Ser Pro Glu Pro Pro Asn
                 245                 250                 255    
 Lys Lys Pro Leu Val Glu Met Asp Glu Thr Pro Gln Val Glu Lys Ser
             260                 265                 270        
 Lys Gly Pro Val Ser Leu Leu Ser Leu Trp Ser Asn Arg Ile Asn Thr
         275                 280                 285            
 Ala Asn Ser Arg Lys His Gln Glu Phe Ala Gly Arg Leu Asn Ser Val
     290                 295                 300                
 Asn Asn Arg Ala Glu Leu Tyr Gln His Leu Lys Glu Glu Asn Gly Met
 305                 310                 315                 320
 Glu Thr Thr Glu Asn Gly Lys Ala Ser Arg Gln
                 325                 330    



      <210> 819
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 819
 Met Glu Leu Ala Leu Leu Cys Gly Leu Val Val Met Ala Gly Val Ile
   1               5                  10                  15    
 Pro Ile Gln Gly Gly Ile Leu Asn Leu Asn Lys Met Val Lys Gln Val
              20                  25                  30        
 Thr Gly Lys Met Pro Ile Leu Ser Tyr Trp Pro Tyr Gly Cys His Cys
          35                  40                  45            
 Gly Leu Gly Gly Arg Gly Gln Pro Lys Asp Ala Thr Asp Trp Cys Cys
      50                  55                  60                
 Gln Thr His Asp Cys Cys Tyr Asp His Leu Lys Thr Gln Gly Cys Gly
  65                  70                  75                  80
 Ile Tyr Lys Asp Tyr Tyr Arg Tyr Asn Phe Ser Gln Gly Asn Ile His
                  85                  90                  95    
 Cys Ser Asp Lys Gly Ser Trp Cys Glu Gln Gln Leu Cys Ala Cys Asp
             100                 105                 110        
 Lys Glu Val Ala Phe Cys Leu Lys Arg Asn Leu Asp Thr Tyr Gln Lys
         115                 120                 125            
 Arg Leu Arg Phe Tyr Trp Arg Pro His Cys Arg Gly Gln Thr Pro Gly
     130                 135                 140                
 Cys
 145



      <210> 820
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 820
 Met Pro Leu Thr Pro Glu Pro Pro Ser Gly Arg Val Glu Gly Pro Pro
   1               5                  10                  15    
 Ala Trp Glu Ala Ala Pro Trp Pro Ser Leu Pro Cys Gly Pro Cys Ile
              20                  25                  30        
 Pro Ile Met Leu Val Leu Ala Thr Leu Ala Ala Leu Phe Ile Leu Thr
          35                  40                  45            
 Thr Ala Val Leu Ala Glu Arg Leu Phe Arg Arg Ala Leu Arg Pro Asp
      50                  55                  60                
 Pro Ser His Arg Ala Pro Thr Leu Val Trp Arg Pro Gly Gly Glu Leu
  65                  70                  75                  80
 Trp Ile Glu Pro Met Gly Thr Ala Arg Glu Arg Ser Glu Asp Trp Tyr
                  85                  90                  95    
 Gly Ser Ala Val Pro Leu Leu Thr Asp Arg Ala Pro Glu Pro Pro Thr
             100                 105                 110        
 Gln Val Gly Thr Leu Glu Ala Arg Ala Thr Ala Pro Thr Leu Ser His
         115                 120                 125            
 Ser Glu Pro Lys Val Leu His Pro Ser Arg Leu Gly Thr Pro Gln Thr
     130                 135                 140                
 Asp Thr Gly Gly Pro Lys His Thr Glu Thr Pro Ile Trp Gly Pro Thr
 145                 150                 155                 160
 Glu Pro
        



      <210> 821
      <211> 402
      <212> PRT
      <213> Homo sapiens


      <400> 821
 Met His Thr Asp Pro Asp Tyr Ser Ala Ala Tyr Val Val Ile Glu Thr
   1               5                  10                  15    
 Asp Ala Glu Asp Gly Ile Lys Gly Cys Gly Ile Thr Phe Thr Leu Gly
              20                  25                  30        
 Lys Gly Thr Glu Val Val Val Cys Ala Val Asn Ala Leu Ala His His
          35                  40                  45            
 Val Leu Asn Lys Asp Leu Lys Asp Ile Val Gly Asp Phe Arg Gly Phe
      50                  55                  60                
 Tyr Arg Gln Leu Thr Ser Asp Gly Gln Leu Arg Trp Ile Gly Pro Glu
  65                  70                  75                  80
 Lys Gly Val Val His Leu Ala Thr Ala Ala Val Leu Asn Ala Val Trp
                  85                  90                  95    
 Asp Leu Trp Ala Lys Gln Glu Gly Lys Pro Val Trp Lys Leu Leu Val
             100                 105                 110        
 Asp Met Asp Pro Arg Met Leu Val Ser Cys Ile Asp Phe Arg Tyr Ile
         115                 120                 125            
 Thr Asp Val Leu Thr Glu Glu Asp Ala Leu Glu Ile Leu Gln Lys Gly
     130                 135                 140                
 Gln Ile Gly Lys Lys Glu Arg Glu Lys Gln Met Leu Ala Gln Gly Tyr
 145                 150                 155                 160
 Pro Ala Tyr Thr Thr Ser Cys Ala Trp Leu Gly Tyr Ser Asp Asp Thr
                 165                 170                 175    
 Leu Lys Gln Leu Cys Ala Gln Ala Leu Lys Asp Gly Trp Thr Arg Phe
             180                 185                 190        
 Lys Val Lys Val Gly Ala Asp Leu Gln Asp Asp Met Arg Arg Cys Gln
         195                 200                 205            
 Ile Ile Arg Asp Met Ile Gly Pro Glu Lys Thr Leu Met Met Asp Ala
     210                 215                 220                
 Asn Gln Arg Trp Asp Val Pro Glu Ala Val Glu Trp Met Ser Lys Leu
 225                 230                 235                 240
 Ala Lys Phe Lys Pro Leu Trp Ile Glu Glu Pro Thr Ser Pro Asp Asp
                 245                 250                 255    
 Ile Leu Gly His Ala Thr Ile Ser Lys Cys His Asn Arg Val Ile Phe
             260                 265                 270        
 Lys Gln Leu Leu Gln Ala Lys Ala Leu Gln Phe Leu Gln Ile Asp Ser
         275                 280                 285            
 Cys Arg Leu Gly Ser Val Asn Glu Asn Leu Ser Val Leu Leu Met Ala
     290                 295                 300                
 Lys Lys Phe Glu Ile Pro Val Cys Pro His Ala Gly Gly Val Gly Leu
 305                 310                 315                 320
 Cys Glu Leu Val Gln His Leu Ile Ile Phe Asp Tyr Ile Ser Val Ser
                 325                 330                 335    
 Ala Ser Leu Glu Asn Arg Val Cys Glu Tyr Val Asp His Leu His Glu
             340                 345                 350        
 His Phe Lys Tyr Pro Val Met Ile Gln Arg Ala Ser Tyr Met Pro Pro
         355                 360                 365            
 Lys Asp Pro Gly Tyr Ser Thr Glu Met Lys Glu Glu Ser Val Lys Lys
     370                 375                 380                
 His Gln Tyr Pro Asp Gly Glu Val Trp Lys Lys Leu Leu Pro Ala Gln
 385                 390                 395                 400
 Glu Asn
        



      <210> 822
      <211> 328
      <212> PRT
      <213> Homo sapiens


      <400> 822
 Met Ala Asp Ile Asp Asn Leu Pro Arg Val Val Lys Arg Arg Val Asn
   1               5                  10                  15    
 Ala Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile Glu Ala Lys Phe
              20                  25                  30        
 Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Val Leu Tyr Gln
          35                  40                  45            
 Pro Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala Ile Tyr Glu Pro
      50                  55                  60                
 Thr Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu Asp Glu Ile Ser
  65                  70                  75                  80
 Glu Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu Lys Lys Asp Glu
                  85                  90                  95    
 Glu Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp Leu Thr Val Phe
             100                 105                 110        
 Lys Asn Val Asp Leu Leu Ser Asp Met Val Gln Glu His Asp Glu Pro
         115                 120                 125            
 Ile Leu Lys His Leu Lys Asp Ile Lys Val Lys Phe Ser Asp Ala Gly
     130                 135                 140                
 Gln Pro Met Ser Phe Val Leu Glu Phe His Phe Glu Pro Asn Glu Tyr
 145                 150                 155                 160
 Phe Thr Asn Glu Val Leu Thr Lys Thr Tyr Arg Met Arg Ser Glu Pro
                 165                 170                 175    
 Asp Asp Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu Ile Met Gly Cys
             180                 185                 190        
 Thr Gly Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Leu Lys
         195                 200                 205            
 Thr Ile Lys Lys Lys Gln Lys His Lys Gly Arg Gly Thr Val Arg Thr
     210                 215                 220                
 Val Thr Lys Thr Val Ser Asn Asp Ser Phe Phe Asn Phe Phe Ala Pro
 225                 230                 235                 240
 Pro Glu Val Pro Glu Ser Gly Asp Leu Asp Asp Asp Ala Glu Ala Ile
                 245                 250                 255    
 Leu Ala Ala Asp Phe Glu Ile Gly His Phe Leu Arg Glu Arg Ile Ile
             260                 265                 270        
 Pro Arg Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile Glu Asp Asp Asp
         275                 280                 285            
 Asp Asp Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu Glu Gly Glu Glu
     290                 295                 300                
 Glu Gly Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro Lys Lys Asp Gln
 305                 310                 315                 320
 Asn Pro Ala Glu Cys Lys Gln Gln
                 325            



      <210> 823
      <211> 392
      <212> PRT
      <213> Homo sapiens


      <400> 823
 Met Asp Leu Phe Gly Asp Leu Pro Glu Pro Glu Arg Ser Pro Arg Pro
   1               5                  10                  15    
 Ala Ala Gly Lys Glu Ala His Lys Gly Pro Leu Leu Phe Asp Asp Leu
              20                  25                  30        
 Pro Pro Ala Ser Ser Thr Asp Ser Gly Ser Gly Gly Pro Leu Leu Phe
          35                  40                  45            
 Asp Asp Leu Pro Pro Ala Ser Ser Gly Asp Ser Gly Ser Leu Ala Thr
      50                  55                  60                
 Ser Ile Ser Gln Met Val Lys Thr Glu Gly Lys Gly Ala Lys Arg Lys
  65                  70                  75                  80
 Thr Ser Glu Glu Glu Lys Asn Gly Ser Glu Glu Leu Val Glu Lys Lys
                  85                  90                  95    
 Val Cys Lys Ala Ser Ser Val Ile Phe Gly Leu Lys Gly Tyr Val Ala
             100                 105                 110        
 Glu Arg Lys Gly Glu Arg Glu Glu Met Gln Asp Ala His Val Ile Leu
         115                 120                 125            
 Asn Asp Ile Thr Glu Glu Cys Arg Pro Pro Ser Ser Leu Ile Thr Arg
     130                 135                 140                
 Val Ser Tyr Phe Ala Val Phe Asp Gly His Gly Gly Ile Arg Ala Ser
 145                 150                 155                 160
 Lys Phe Ala Ala Gln Asn Leu His Gln Asn Leu Ile Arg Lys Phe Pro
                 165                 170                 175    
 Lys Gly Asp Val Ile Ser Val Glu Lys Thr Val Lys Arg Cys Leu Leu
             180                 185                 190        
 Asp Thr Phe Lys His Thr Asp Glu Glu Phe Leu Lys Gln Ala Ser Ser
         195                 200                 205            
 Gln Lys Pro Ala Trp Lys Asp Gly Ser Thr Ala Thr Cys Val Leu Ala
     210                 215                 220                
 Val Asp Asn Ile Leu Tyr Ile Ala Asn Leu Gly Asp Ser Arg Ala Ile
 225                 230                 235                 240
 Leu Cys Arg Tyr Asn Glu Glu Ser Gln Lys His Ala Ala Leu Ser Leu
                 245                 250                 255    
 Ser Lys Glu His Asn Pro Thr Gln Tyr Glu Glu Arg Met Arg Ile Gln
             260                 265                 270        
 Lys Ala Gly Gly Asn Val Arg Asp Gly Arg Val Leu Gly Val Leu Glu
         275                 280                 285            
 Val Ser Arg Ser Ile Gly Asp Gly Gln Tyr Lys Arg Cys Gly Val Thr
     290                 295                 300                
 Ser Val Pro Asp Ile Arg Arg Cys Gln Leu Thr Pro Asn Asp Arg Phe
 305                 310                 315                 320
 Ile Leu Leu Ala Cys Asp Gly Leu Phe Lys Val Phe Thr Pro Glu Glu
                 325                 330                 335    
 Ala Val Asn Phe Ile Leu Ser Cys Leu Glu Asp Glu Lys Ile Gln Thr
             340                 345                 350        
 Arg Glu Gly Lys Ser Ala Ala Glu Ala Arg Tyr Glu Ala Ala Cys Asn
         355                 360                 365            
 Arg Leu Ala Asn Lys Ala Val Gln Arg Gly Ser Ala Asp Asn Val Thr
     370                 375                 380                
 Val Met Val Val Arg Ile Gly His
 385                 390        



      <210> 824
      <211> 235
      <212> PRT
      <213> Homo sapiens


      <400> 824
 Met Leu Leu Leu Leu Pro Glu Ala Gly Arg Pro Ala Leu Ser Pro Gly
   1               5                  10                  15    
 His Ser Pro Pro Ser Gly Ala Pro Gly Pro Pro Ala Gly Val Arg Thr
              20                  25                  30        
 Thr Arg Leu Pro Ser Pro Thr Pro Arg Leu Pro Thr Ser Ser Pro Ser
          35                  40                  45            
 Ala Pro Val Trp Leu Leu Ser Thr Leu Leu Ala Thr Pro Val Pro Thr
      50                  55                  60                
 Ala Ser Leu Leu Gly Asn Leu Arg Pro Pro Ser Leu Leu Gln Gly Glu
  65                  70                  75                  80
 Val Met Gly Thr Pro Ser Ser Pro Arg Gly Pro Glu Ser Pro Arg Leu
                  85                  90                  95    
 Ala Ala Gly Pro Ser Pro Cys Trp His Leu Gly Ala Met His Glu Ser
             100                 105                 110        
 Arg Ser Arg Trp Thr Glu Pro Gly Cys Ser Gln Cys Trp Cys Glu Asp
         115                 120                 125            
 Gly Lys Val Thr Cys Glu Lys Val Arg Cys Glu Ala Ala Cys Ser His
     130                 135                 140                
 Pro Ile Pro Ser Arg Asp Gly Gly Cys Cys Pro Ser Cys Thr Gly Cys
 145                 150                 155                 160
 Phe His Ser Gly Val Val Arg Ala Glu Gly Asp Val Phe Ser Pro Pro
                 165                 170                 175    
 Asn Glu Asn Cys Thr Val Cys Val Cys Leu Ala Gly Asn Val Ser Cys
             180                 185                 190        
 Ile Ser Pro Glu Cys Pro Ser Gly Pro Cys Gln Thr Pro Pro Thr Asp
         195                 200                 205            
 Gly Leu Leu Tyr Leu Cys Ser Ser Glu Met Leu Phe Pro Arg Pro Val
     210                 215                 220                
 Val Arg Arg Arg Gly Cys Val Gln Trp Gly Trp
 225                 230                 235



      <210> 825
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 825
 Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Phe
   1               5                  10                  15    
 Ile Ile Met Thr Trp Lys Val Cys Ile Thr Leu Ala Ile Thr Ser Trp
              20                  25                  30        
 Thr Cys Gly Ser Leu Leu Ala Met Val His Val Ser Leu Ile Leu Arg
          35                  40                  45            
 Leu Pro Phe Cys Gly Pro Arg Glu Ile Asn His Phe Phe Cys Glu Ile
      50                  55                  60                
 Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp Leu Asn Gln Val
  65                  70                  75                  80
 Val Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly Pro Leu Cys Leu
                  85                  90                  95    
 Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile Leu Arg Ile Gln
             100                 105                 110        
 Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser His Leu
         115                 120                 125            
 Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val Met Tyr Met Ala
     130                 135                 140                
 Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val Leu Phe Leu Phe
 145                 150                 155                 160
 Tyr Ser Ser Phe Asn Pro Met Leu Asn Pro Leu Ile Tyr Asn Leu Arg
                 165                 170                 175    
 Asn Val Glu Val Lys Gly Ala Leu Arg Arg Ala Leu Cys Lys Glu Ser
             180                 185                 190        
 His Ser
        



      <210> 826
      <211> 308
      <212> PRT
      <213> Homo sapiens


      <400> 826
 Met Val Lys Asn Gln Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe
   1               5                  10                  15    
 Leu Leu Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu
              20                  25                  30        
 Phe Tyr Ile Phe Thr Leu Leu Gly Asn Gly Ala Ile Leu Gly Leu Ile
          35                  40                  45            
 Ser Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His
      50                  55                  60                
 Leu Ala Val Val Asp Ile Ala Tyr Thr Arg Asn Thr Val Pro Gln Met
  65                  70                  75                  80
 Leu Ala Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys
                  85                  90                  95    
 Met Thr Gln Thr Phe Leu Cys Leu Ser Phe Gly His Ser Glu Cys Leu
             100                 105                 110        
 Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro
         115                 120                 125            
 Leu Arg Tyr Ser Val Ile Met Thr Cys Cys Ile Thr Leu Ala Ile Thr
     130                 135                 140                
 Ser Trp Thr Cys Gly Ser Leu Leu Ala Met Val His Val Ser Leu Ile
 145                 150                 155                 160
 Leu Arg Leu Pro Phe Cys Gly Pro Arg Glu Ile Asn His Phe Phe Cys
                 165                 170                 175    
 Glu Ile Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp Leu Asn
             180                 185                 190        
 Gln Val Val Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly Pro Leu
         195                 200                 205            
 Cys Leu Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile Leu Arg
     210                 215                 220                
 Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser
 225                 230                 235                 240
 His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val Met Tyr
                 245                 250                 255    
 Met Ala Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val Leu Phe
             260                 265                 270        
 Leu Phe Tyr Ser Ser Phe Asn Pro Met Leu Asn Pro Leu Ile Tyr Asn
         275                 280                 285            
 Leu Arg Asn Val Glu Val Lys Gly Ala Leu Arg Arg Ala Leu Cys Lys
     290                 295                 300                
 Glu Ser His Ser
 305            



      <210> 827
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 827
 Ala Cys Pro Val Leu Cys Arg Gly Asn Gly Gln Tyr Ser Lys Gly Arg
   1               5                  10                  15    
 Cys Leu Cys Phe Ser Gly Cys Lys Gly Thr Glu Cys Asp Val Pro Thr
              20                  25                  30        
 Thr Gln Cys Ile Asp Pro Gln Cys Gly Gly Arg Gly Ile Cys Ile Met
          35                  40                  45            
 Gly Ser Cys Ala Cys Asn Ser Gly Tyr Lys Gly Glu Ser Cys Glu Glu
      50                  55                  60                
 Ala Pro Arg Tyr Ile Pro Glu Lys Glu Arg Lys Lys Lys Lys Ala Ser
  65                  70                  75                  80
 Asn Leu His Val
                



      <210> 828
      <211> 731
      <212> PRT
      <213> Homo sapiens


      <400> 828
 Met Lys Leu Arg Ser Ser His Asn Ala Ser Lys Thr Leu Asn Ala Asn
   1               5                  10                  15    
 Asn Met Glu Thr Leu Ile Glu Cys Gln Ser Glu Gly Asp Ile Lys Glu
              20                  25                  30        
 His Pro Leu Leu Ala Ser Cys Glu Ser Glu Asp Ser Ile Cys Gln Leu
          35                  40                  45            
 Ile Glu Val Lys Lys Arg Lys Lys Val Leu Ser Trp Pro Phe Leu Met
      50                  55                  60                
 Arg Arg Leu Ser Pro Ala Ser Asp Phe Ser Gly Ala Leu Glu Thr Asp
  65                  70                  75                  80
 Leu Lys Ala Ser Leu Phe Asp Gln Pro Leu Ser Ile Ile Cys Gly Asp
                  85                  90                  95    
 Ser Asp Thr Leu Pro Arg Pro Ile Gln Asp Ile Leu Thr Ile Leu Cys
             100                 105                 110        
 Leu Lys Gly Pro Ser Thr Glu Gly Ile Phe Arg Arg Ala Ala Asn Glu
         115                 120                 125            
 Lys Ala Arg Lys Glu Leu Lys Glu Glu Leu Asn Ser Gly Asp Ala Val
     130                 135                 140                
 Asp Leu Glu Arg Leu Pro Val His Leu Leu Ala Val Val Phe Lys Asp
 145                 150                 155                 160
 Phe Leu Arg Ser Ile Pro Arg Lys Leu Leu Ser Ser Asp Leu Phe Glu
                 165                 170                 175    
 Glu Trp Met Gly Ala Leu Glu Met Gln Asp Glu Glu Asp Arg Ile Glu
             180                 185                 190        
 Ala Leu Lys Gln Val Ala Asp Lys Leu Pro Arg Pro Asn Leu Leu Leu
         195                 200                 205            
 Leu Lys His Leu Val Tyr Val Leu His Leu Ile Ser Lys Asn Ser Glu
     210                 215                 220                
 Val Asn Arg Met Asp Ser Ser Asn Leu Ala Ile Cys Ile Gly Pro Asn
 225                 230                 235                 240
 Met Leu Thr Leu Glu Asn Asp Gln Ser Leu Ser Phe Glu Ala Gln Lys
                 245                 250                 255    
 Asp Leu Asn Asn Lys Val Lys Thr Leu Val Glu Phe Leu Ile Asp Asn
             260                 265                 270        
 Cys Phe Glu Ile Phe Gly Glu Asn Ile Pro Val His Ser Ser Ile Thr
         275                 280                 285            
 Ser Asp Asp Ser Leu Glu His Thr Asp Ser Ser Asp Val Ser Thr Leu
     290                 295                 300                
 Gln Asn Asp Ser Ala Tyr Asp Ser Asn Asp Pro Asp Val Glu Ser Asn
 305                 310                 315                 320
 Ser Ser Ser Gly Ile Ser Ser Pro Ser Arg Gln Pro Gln Val Pro Met
                 325                 330                 335    
 Ala Thr Ala Ala Gly Leu Asp Ser Ala Gly Pro Gln Asp Ala Arg Glu
             340                 345                 350        
 Val Ser Pro Glu Pro Ile Val Ser Thr Val Ala Arg Leu Lys Ser Ser
         355                 360                 365            
 Leu Ala Gln Pro Asp Arg Arg Tyr Ser Glu Pro Ser Met Pro Ser Ser
     370                 375                 380                
 Gln Glu Cys Leu Glu Ser Arg Val Thr Asn Gln Thr Leu Thr Lys Ser
 385                 390                 395                 400
 Glu Gly Asp Phe Pro Val Pro Arg Val Gly Ser Arg Leu Glu Ser Glu
                 405                 410                 415    
 Glu Ala Glu Asp Pro Phe Pro Glu Glu Val Phe Pro Ala Val Gln Gly
             420                 425                 430        
 Lys Thr Lys Arg Pro Val Asp Leu Lys Ile Lys Asn Leu Ala Pro Gly
         435                 440                 445            
 Ser Val Leu Pro Arg Ala Leu Val Leu Lys Ala Phe Ser Ser Ser Ser
     450                 455                 460                
 Leu Asp Ala Ser Ser Asp Ser Ser Pro Val Ala Ser Pro Ser Ser Pro
 465                 470                 475                 480
 Lys Arg Asn Phe Phe Ser Arg His Gln Ser Phe Thr Thr Lys Thr Glu
                 485                 490                 495    
 Lys Gly Lys Pro Ser Arg Glu Ile Lys Lys His Ser Met Ser Phe Thr
             500                 505                 510        
 Phe Ala Pro His Lys Lys Val Leu Thr Lys Asn Leu Ser Ala Gly Ser
         515                 520                 525            
 Gly Lys Ser Gln Asp Phe Thr Arg Asp His Val Pro Arg Gly Val Arg
     530                 535                 540                
 Lys Glu Ser Gln Leu Ala Gly Arg Ile Val Gln Glu Asn Gly Cys Glu
 545                 550                 555                 560
 Thr His Asn Gln Thr Ala Arg Gly Phe Cys Leu Arg Pro His Ala Leu
                 565                 570                 575    
 Ser Val Asp Asp Val Phe Gln Gly Ala Asp Trp Glu Arg Pro Gly Ser
             580                 585                 590        
 Pro Pro Ser Tyr Glu Glu Ala Met Gln Gly Pro Ala Ala Arg Leu Val
         595                 600                 605            
 Ala Ser Glu Ser Gln Thr Val Gly Ser Met Thr Val Gly Ser Met Arg
     610                 615                 620                
 Ala Arg Met Leu Glu Ala His Cys Leu Leu Pro Pro Leu Pro Pro Ala
 625                 630                 635                 640
 His His Val Glu Asp Ser Arg His Arg Gly Ser Lys Glu Pro Leu Pro
                 645                 650                 655    
 Gly His Gly Leu Ser Pro Leu Pro Glu Arg Trp Lys Gln Ser Arg Thr
             660                 665                 670        
 Val His Ala Ser Gly Asp Ser Leu Gly His Val Ser Gly Pro Gly Arg
         675                 680                 685            
 Pro Glu Leu Leu Pro Leu Arg Thr Val Ser Glu Ser Val Gln Arg Asn
     690                 695                 700                
 Lys Arg Asp Cys Leu Val Arg Arg Cys Ser Gln Pro Val Phe Glu Ala
 705                 710                 715                 720
 Asp Gln Phe Gln Tyr Ala Lys Glu Ser Tyr Ile
                 725                 730    



      <210> 829
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 829
 Met Ser Asp Phe Ser Gly Val Ile Leu Ser Pro Gly Phe Pro Gly Asn
   1               5                  10                  15    
 Tyr Pro Ser Ser Leu Asp Cys Thr Trp Thr Ile Asn Leu Pro Ile Gly
              20                  25                  30        
 Phe Gly Val His Leu Gln Phe Val Asn Phe Ser Thr Glu Thr Ile His
          35                  40                  45            
 Asp Tyr Leu Glu Val Arg Ser Gly Ser Ser Glu Thr Ser Thr Val Ile
      50                  55                  60                
 Gly Arg Leu Ser Gly Pro Gln Ile Pro Ser Ser Leu Phe Ser Thr Thr
  65                  70                  75                  80
 His Glu Thr Ser Leu Tyr Phe His Ser Asp Tyr Ser Gln Asn Lys Gln
                  85                  90                  95    
 Gly Phe His Ile Val Tyr Gln Gly Lys Arg Asn Asn Lys Lys
             100                 105                 110



      <210> 830
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 830
 Met Ser Asp Phe Ser Gly Val Ile Leu Ser Pro Gly Phe Pro Gly Asn
   1               5                  10                  15    
 Tyr Pro Ser Ser Leu Asp Cys Thr Trp Thr Ile Asn Leu Pro Ile Gly
              20                  25                  30        
 Phe Gly Val His Leu Gln Phe Val Asn Phe Ser Thr Glu Thr Ile His
          35                  40                  45            
 Asp Tyr Leu Glu Val Arg Ser Gly Ser Ser Glu Thr Ser Thr Val Ile
      50                  55                  60                
 Gly Arg Leu Ser Gly Pro Gln Ile Pro Ser Ser Leu Phe Ser Thr Thr
  65                  70                  75                  80
 His Glu Thr Ser Leu Tyr Phe His Ser Asp Tyr Ser Gln Asn Lys Gln
                  85                  90                  95    
 Gly Phe His Ile Val Tyr Gln Gly Lys Arg Asn Asn Lys Lys
             100                 105                 110



      <210> 831
      <211> 317
      <212> PRT
      <213> Homo sapiens


      <400> 831
 Met Leu Gln Gln Val Asn Gly His Asn Pro Gly Ser Asp Gly Gln Ala
   1               5                  10                  15    
 Arg Glu Tyr Leu Arg Glu Asp Leu Gln Glu Phe Leu Gly Gly Glu Val
              20                  25                  30        
 Leu Leu Tyr Lys Leu Asp Asp Leu Thr Arg Val Asn Pro Val Thr Leu
          35                  40                  45            
 Glu Thr Val Leu Arg Cys Leu Gln Ala Arg Tyr Met Ala Asp Thr Phe
      50                  55                  60                
 Tyr Thr Asn Ala Gly Cys Thr Leu Val Ala Leu Asn Pro Phe Lys Pro
  65                  70                  75                  80
 Val Pro Gln Leu Tyr Ser Pro Glu Leu Met Arg Glu Tyr His Ala Ala
                  85                  90                  95    
 Pro Gln Pro Gln Lys Leu Lys Pro His Val Phe Thr Val Gly Glu Gln
             100                 105                 110        
 Thr Tyr Arg Asn Val Lys Ser Leu Ile Glu Pro Val Asn Gln Ser Ile
         115                 120                 125            
 Val Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Trp Thr Ser Arg Cys
     130                 135                 140                
 Leu Met Lys Phe Tyr Ala Val Val Ala Thr Ser Pro Ala Ser Trp Glu
 145                 150                 155                 160
 Ser His Lys Ile Ala Glu Arg Ile Glu Gln Arg Ile Leu Asn Ser Asn
                 165                 170                 175    
 Pro Val Met Glu Ala Phe Gly Asn Ala Cys Thr Leu Arg Asn Asn Asn
             180                 185                 190        
 Ser Ser Arg Phe Gly Lys Phe Ile Gln Leu Gln Leu Asn Arg Ala Gln
         195                 200                 205            
 Gln Met Thr Gly Ala Ala Val Gln Thr Tyr Leu Leu Glu Lys Thr Arg
     210                 215                 220                
 Val Ala Cys Gln Ala Ser Ser Glu Arg Asn Phe His Ile Phe Tyr Gln
 225                 230                 235                 240
 Ile Cys Lys Gly Ala Ser Glu Asp Glu Arg Leu Gln Trp His Leu Pro
                 245                 250                 255    
 Glu Gly Ala Ala Phe Ser Trp Leu Pro Asn Pro Glu Arg Ser Leu Glu
             260                 265                 270        
 Glu Asp Cys Phe Glu Val Thr Arg Glu Ala Met Leu His Leu Gly Ile
         275                 280                 285            
 Asp Thr Pro Thr Gln Asn Asn Ile Phe Lys Val Arg Arg Lys Ala Thr
     290                 295                 300                
 Pro Leu Lys Phe Gly Arg Asp Asp Gly Gln Pro Phe Ala
 305                 310                 315        



      <210> 832
      <211> 417
      <212> PRT
      <213> Homo sapiens


      <400> 832
 Met Leu Gln Gln Val Asn Gly His Asn Pro Gly Ser Asp Gly Gln Ala
   1               5                  10                  15    
 Arg Glu Tyr Leu Arg Glu Asp Leu Gln Glu Phe Leu Gly Gly Glu Val
              20                  25                  30        
 Leu Leu Tyr Lys Leu Asp Asp Leu Thr Arg Val Asn Pro Val Thr Leu
          35                  40                  45            
 Glu Thr Val Leu Arg Cys Leu Gln Ala Arg Tyr Met Ala Asp Thr Phe
      50                  55                  60                
 Tyr Thr Asn Ala Gly Cys Thr Leu Val Ala Leu Asn Pro Phe Lys Pro
  65                  70                  75                  80
 Val Pro Gln Leu Tyr Ser Pro Glu Leu Met Arg Glu Tyr His Ala Ala
                  85                  90                  95    
 Pro Gln Pro Gln Lys Leu Lys Pro His Val Phe Thr Val Gly Glu Gln
             100                 105                 110        
 Thr Tyr Arg Asn Val Lys Ser Leu Ile Glu Pro Val Asn Gln Ser Ile
         115                 120                 125            
 Val Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Trp Thr Ser Arg Cys
     130                 135                 140                
 Leu Met Lys Phe Tyr Ala Val Val Ala Ala Ser Pro Ala Ser Trp Glu
 145                 150                 155                 160
 Ser His Lys Ile Ala Glu Arg Ile Glu Gln Arg Ile Leu Asn Ser Asn
                 165                 170                 175    
 Pro Val Met Glu Ala Phe Gly Asn Ala Cys Thr Leu Arg Asn Asn Asn
             180                 185                 190        
 Ser Ser Arg Phe Gly Lys Phe Ile Gln Leu Gln Leu Asn Arg Ala Gln
         195                 200                 205            
 Gln Met Thr Gly Ala Ala Val Gln Thr Tyr Leu Leu Glu Lys Thr Arg
     210                 215                 220                
 Val Ala Cys Gln Ala Ser Ser Glu Arg Asn Phe His Ile Phe Tyr Gln
 225                 230                 235                 240
 Ile Cys Lys Gly Ala Ser Glu Asp Glu Arg Leu Gln Trp His Leu Pro
                 245                 250                 255    
 Glu Gly Ala Ala Phe Ser Trp Leu Pro Asn Pro Glu Arg Ser Leu Glu
             260                 265                 270        
 Glu Asp Cys Phe Glu Val Thr Arg Glu Ala Met Leu His Leu Gly Ile
         275                 280                 285            
 Asp Thr Pro Thr Gln Asn Asn Ile Phe Lys Val Leu Ala Gly Leu Leu
     290                 295                 300                
 His Leu Gly Asn Ile Gln Phe Ala Ala Ser Glu Asp Glu Ala Gln Pro
 305                 310                 315                 320
 Cys Gln Pro Met Asp Asp Ala Lys Tyr Ser Val Arg Thr Ala Ala Ser
                 325                 330                 335    
 Leu Leu Gly Leu Pro Glu Asp Val Leu Leu Glu Met Val Gln Ile Arg
             340                 345                 350        
 Thr Ile Arg Ala Gly Arg Gln Gln Gln Val Phe Arg Lys Pro Cys Ala
         355                 360                 365            
 Arg Ala Glu Cys Asp Thr Arg Arg Asp Cys Leu Ala Lys Leu Ile Tyr
     370                 375                 380                
 Ala Arg Leu Leu Thr Gly Leu Val Ser Arg Asp Gln Ser Asn Ile Ser
 385                 390                 395                 400
 Gly Arg His Asp Ser Trp Asn His Leu His Arg Leu Leu Asn Ala Met
                 405                 410                 415    
 Ala
    



      <210> 833
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 833
 Met Gln His Val Ser Gly His Val Pro Asp Pro Ile Ala Ile Met Tyr
   1               5                  10                  15    
 Val Cys Pro Pro Cys Gly His Thr Thr Trp Ala Leu Gly Leu Lys Phe
              20                  25                  30        
 Leu Ser Ser Ser Ser Gln Asn Phe Cys Ala Pro Val Leu Phe Leu Ile
          35                  40                  45            
 Leu His Thr Gly Gly Asn
      50                



      <210> 834
      <211> 442
      <212> PRT
      <213> Homo sapiens


      <400> 834
 Met Pro Ala Ile Ala Val Leu Ala Ala Ala Ala Ala Ala Trp Cys Phe
   1               5                  10                  15    
 Leu Gln Val Glu Ser Arg His Leu Asp Ala Leu Ala Gly Gly Ala Gly
              20                  25                  30        
 Pro Asn His Gly Asn Phe Leu Asp Asn Asp Gln Trp Leu Ser Thr Val
          35                  40                  45            
 Ser Gln Tyr Asp Arg Asp Lys Tyr Trp Asn Arg Phe Arg Asp Glu Val
      50                  55                  60                
 Glu Asp Asp Tyr Phe Arg Asn Trp Asn Pro Asn Lys Pro Phe Asp Gln
  65                  70                  75                  80
 Ala Leu Asp Pro Ser Lys Asp Pro Cys Leu Lys Val Lys Cys Ser Pro
                  85                  90                  95    
 His Lys Val Cys Val Thr Gln Asp Tyr Gln Thr Ala Leu Cys Val Ser
             100                 105                 110        
 Arg Lys His Leu Leu Pro Arg Gln Lys Lys Gly Asn Val Ala Gln Lys
         115                 120                 125            
 His Trp Val Gly Pro Ser Asn Leu Val Lys Cys Lys Pro Cys Pro Val
     130                 135                 140                
 Ala Gln Ser Ala Met Val Cys Gly Ser Asp Gly His Ser Tyr Thr Ser
 145                 150                 155                 160
 Lys Cys Lys Leu Glu Phe His Ala Cys Ser Thr Gly Lys Ser Leu Ala
                 165                 170                 175    
 Thr Leu Cys Asp Gly Pro Cys Pro Cys Leu Pro Glu Pro Glu Pro Pro
             180                 185                 190        
 Lys His Lys Ala Glu Arg Ser Ala Cys Thr Asp Lys Glu Leu Arg Asn
         195                 200                 205            
 Leu Ala Ser Arg Leu Lys Asp Trp Phe Gly Ala Leu His Glu Asp Ala
     210                 215                 220                
 Asn Arg Val Ile Lys Pro Thr Ser Ser Asn Thr Ala Gln Gly Arg Phe
 225                 230                 235                 240
 Asp Thr Ser Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp Met Phe
                 245                 250                 255    
 Asn Lys Leu Asp Met Asn Tyr Asp Leu Leu Leu Asp Pro Ser Glu Ile
             260                 265                 270        
 Asn Ala Ile Tyr Leu Asp Lys Tyr Glu Pro Cys Ile Lys Pro Leu Phe
         275                 280                 285            
 Asn Ser Cys Asp Ser Phe Lys Asp Gly Lys Leu Ser Asn Asn Glu Trp
     290                 295                 300                
 Cys Tyr Cys Phe Gln Lys Pro Gly Gly Leu Pro Cys Gln Asn Glu Met
 305                 310                 315                 320
 Asn Arg Ile Gln Lys Leu Ser Lys Gly Lys Ser Leu Leu Gly Ala Phe
                 325                 330                 335    
 Ile Pro Arg Cys Asn Glu Glu Gly Tyr Tyr Lys Ala Thr Gln Cys His
             340                 345                 350        
 Gly Ser Thr Gly Gln Cys Trp Cys Val Asp Lys Tyr Gly Asn Glu Leu
         355                 360                 365            
 Ala Gly Ser Arg Lys Gln Gly Ala Val Ser Cys Glu Glu Glu Gln Glu
     370                 375                 380                
 Thr Ser Gly Asp Phe Gly Ser Gly Gly Ser Val Val Leu Leu Asp Asp
 385                 390                 395                 400
 Leu Glu Tyr Glu Arg Glu Leu Gly Pro Lys Asp Lys Glu Gly Lys Leu
                 405                 410                 415    
 Arg Val His Thr Arg Ala Val Thr Glu Asp Asp Glu Asp Glu Asp Asp
             420                 425                 430        
 Asp Lys Glu Asp Glu Val Gly Tyr Ile Trp
         435                 440        



      <210> 835
      <211> 569
      <212> PRT
      <213> Homo sapiens


      <400> 835
 Met Ala Pro Thr Leu Ala Thr Ala His Arg Arg Arg Trp Trp Met Ala
   1               5                  10                  15    
 Cys Thr Ala Val Leu Glu Asn Leu Leu Phe Ser Ala Val Leu Leu Gly
              20                  25                  30        
 Trp Gly Ser Leu Leu Ile Met Leu Lys Ser Glu Gly Phe Tyr Ser Tyr
          35                  40                  45            
 Leu Cys Thr Glu Pro Glu Asn Val Thr Asn Gly Thr Val Gly Gly Thr
      50                  55                  60                
 Ala Glu Pro Gly His Glu Glu Val Ser Trp Met Asn Gly Trp Leu Ser
  65                  70                  75                  80
 Cys Gln Ala Gln Asp Glu Met Leu Asn Leu Ala Phe Thr Val Gly Ser
                  85                  90                  95    
 Phe Leu Leu Ser Ala Ile Thr Leu Pro Leu Gly Ile Val Met Asp Lys
             100                 105                 110        
 Tyr Gly Pro Arg Lys Leu Arg Leu Leu Gly Ser Ala Cys Phe Ala Val
         115                 120                 125            
 Ser Cys Leu Leu Ile Ala Tyr Gly Ala Arg Lys Pro Asn Ala Leu Ser
     130                 135                 140                
 Val Leu Thr Phe Ile Ala Leu Ala Leu Asn Gly Phe Gly Gly Met Cys
 145                 150                 155                 160
 Met Thr Phe Thr Ser Leu Thr Leu Pro Asn Met Phe Gly Asp Leu Arg
                 165                 170                 175    
 Phe Thr Phe Ile Ala Leu Met Ile Gly Ser Tyr Ala Ser Ser Ala Val
             180                 185                 190        
 Thr Phe Pro Gly Ile Lys Leu Ile Tyr Asp Ala Gly Val Ser Phe Ile
         195                 200                 205            
 Val Val Leu Val Val Trp Ala Gly Cys Ser Gly Leu Val Phe Leu Asn
     210                 215                 220                
 Cys Phe Phe Asn Trp Pro Leu Glu Pro Phe Pro Gly Pro Glu Asp Met
 225                 230                 235                 240
 Asp Tyr Ser Val Lys Ile Lys Phe Ser Trp Leu Gly Phe Asp His Lys
                 245                 250                 255    
 Ile Thr Gly Lys Gln Phe Tyr Lys Gln Val Thr Thr Val Gly Arg Arg
             260                 265                 270        
 Leu Ser Val Gly Ser Ser Met Arg Ser Ala Lys Glu Gln Val Ala Leu
         275                 280                 285            
 Gln Glu Gly His Lys Leu Cys Leu Ser Thr Val Asp Leu Glu Val Lys
     290                 295                 300                
 Cys Gln Pro Asp Ala Ala Val Ala Pro Ser Phe Met His Ser Val Phe
 305                 310                 315                 320
 Ser Pro Ile Leu Leu Leu Ser Leu Val Thr Met Cys Val Thr Gln Leu
                 325                 330                 335    
 Arg Leu Ile Phe Tyr Met Gly Ala Met Asn Asn Ile Leu Lys Phe Leu
             340                 345                 350        
 Val Ser Gly Asp Gln Lys Thr Val Gly Leu Tyr Thr Ser Ile Phe Gly
         355                 360                 365            
 Val Leu Gln Leu Leu Cys Leu Leu Thr Ala Pro Val Ile Gly Tyr Ile
     370                 375                 380                
 Met Asp Trp Arg Leu Lys Glu Cys Glu Asp Ala Ser Glu Glu Pro Glu
 385                 390                 395                 400
 Glu Lys Asp Ala Asn Gln Gly Glu Lys Lys Lys Lys Lys Arg Asp Arg
                 405                 410                 415    
 Gln Ile Gln Lys Ile Thr Asn Ala Met Arg Ala Phe Ala Phe Thr Asn
             420                 425                 430        
 Leu Leu Leu Val Gly Phe Gly Val Thr Cys Leu Ile Pro Asn Leu Pro
         435                 440                 445            
 Leu Gln Ile Leu Ser Phe Ile Leu His Thr Ile Val Arg Gly Phe Ile
     450                 455                 460                
 His Ser Ala Val Gly Gly Leu Tyr Ala Ala Val Tyr Pro Ser Thr Gln
 465                 470                 475                 480
 Phe Gly Ser Leu Thr Gly Leu Gln Ser Leu Ile Ser Ala Leu Phe Ala
                 485                 490                 495    
 Leu Leu Gln Gln Pro Leu Phe Leu Ala Met Met Gly Pro Leu Gln Gly
             500                 505                 510        
 Asp Pro Leu Trp Val Asn Val Gly Leu Leu Leu Leu Ser Leu Leu Gly
         515                 520                 525            
 Phe Cys Leu Pro Leu Tyr Leu Ile Cys Tyr Arg Arg Gln Leu Glu Arg
     530                 535                 540                
 Gln Leu Gln Gln Arg Gln Glu Asp Asp Lys Leu Phe Leu Lys Ile Asn
 545                 550                 555                 560
 Gly Ser Ser Asn Gln Glu Ala Phe Val
                 565                



      <210> 836
      <211> 569
      <212> PRT
      <213> Homo sapiens


      <400> 836
 Met Ala Pro Thr Leu Ala Thr Ala His Arg Arg Arg Trp Trp Met Ala
   1               5                  10                  15    
 Cys Thr Ala Val Leu Glu Asn Leu Leu Phe Ser Ala Val Leu Leu Gly
              20                  25                  30        
 Trp Gly Ser Leu Leu Ile Met Leu Lys Ser Glu Gly Phe Tyr Ser Tyr
          35                  40                  45            
 Leu Cys Thr Glu Pro Glu Asn Val Thr Asn Gly Thr Val Gly Gly Thr
      50                  55                  60                
 Ala Glu Pro Gly His Glu Glu Val Ser Trp Met Asn Gly Trp Leu Ser
  65                  70                  75                  80
 Cys Gln Ala Gln Asp Glu Met Leu Asn Leu Ala Phe Thr Val Gly Ser
                  85                  90                  95    
 Phe Leu Leu Ser Ala Ile Thr Leu Pro Leu Gly Ile Val Met Asp Lys
             100                 105                 110        
 Tyr Gly Pro Arg Lys Leu Arg Leu Leu Gly Ser Ala Cys Phe Ala Val
         115                 120                 125            
 Ser Cys Leu Leu Ile Ala Tyr Gly Ala Ser Lys Pro Asn Ala Leu Ser
     130                 135                 140                
 Val Leu Ile Phe Ile Ala Leu Ala Leu Asn Gly Phe Gly Gly Met Cys
 145                 150                 155                 160
 Met Thr Phe Thr Ser Leu Thr Leu Pro Asn Met Phe Gly Asp Leu Arg
                 165                 170                 175    
 Ser Thr Phe Ile Ala Leu Met Ile Gly Ser Tyr Ala Ser Ser Ala Val
             180                 185                 190        
 Thr Phe Pro Gly Ile Lys Leu Ile Tyr Asp Ala Gly Val Ser Phe Ile
         195                 200                 205            
 Val Val Leu Val Val Trp Ala Gly Cys Ser Gly Leu Val Phe Leu Asn
     210                 215                 220                
 Cys Phe Phe Asn Trp Pro Leu Glu Pro Phe Pro Gly Pro Glu Asp Met
 225                 230                 235                 240
 Asp Tyr Ser Val Lys Ile Lys Phe Ser Trp Leu Gly Phe Asp His Lys
                 245                 250                 255    
 Ile Thr Gly Lys Gln Phe Tyr Lys Gln Val Thr Thr Val Gly Arg Arg
             260                 265                 270        
 Leu Ser Val Gly Ser Ser Met Arg Ser Ala Lys Glu Gln Val Ala Leu
         275                 280                 285            
 Gln Glu Gly His Lys Leu Cys Leu Ser Thr Val Asp Leu Glu Val Lys
     290                 295                 300                
 Cys Gln Pro Asp Ala Ala Val Ala Pro Ser Phe Met His Ser Val Phe
 305                 310                 315                 320
 Ser Pro Ile Leu Leu Leu Ser Leu Val Thr Met Cys Val Thr Gln Leu
                 325                 330                 335    
 Arg Leu Ile Phe Tyr Met Gly Ala Met Asn Asn Ile Leu Lys Phe Leu
             340                 345                 350        
 Val Ser Gly Asp Gln Lys Thr Val Gly Leu Tyr Thr Ser Ile Phe Gly
         355                 360                 365            
 Val Leu Gln Leu Leu Cys Leu Leu Thr Ala Pro Val Ile Gly Tyr Ile
     370                 375                 380                
 Met Asp Trp Arg Leu Lys Glu Cys Glu Asp Ala Ser Glu Glu Pro Glu
 385                 390                 395                 400
 Glu Lys Asp Ala Asn Gln Gly Glu Lys Lys Lys Lys Lys Arg Asp Arg
                 405                 410                 415    
 Gln Ile Gln Lys Ile Thr Asn Ala Met Arg Ala Phe Ala Phe Thr Asn
             420                 425                 430        
 Leu Leu Leu Val Gly Phe Gly Val Thr Cys Leu Ile Pro Asn Leu Pro
         435                 440                 445            
 Leu Gln Ile Leu Ser Phe Ile Leu His Thr Ile Val Arg Gly Phe Ile
     450                 455                 460                
 His Ser Ala Val Gly Gly Leu Tyr Ala Ala Val Tyr Pro Ser Thr Gln
 465                 470                 475                 480
 Phe Gly Ser Leu Thr Gly Leu Gln Ser Leu Ile Ser Ala Leu Phe Ala
                 485                 490                 495    
 Leu Leu Gln Gln Pro Leu Phe Leu Ala Met Met Gly Pro Leu Gln Gly
             500                 505                 510        
 Asp Pro Leu Trp Val Asn Val Gly Leu Leu Leu Leu Ser Leu Leu Gly
         515                 520                 525            
 Phe Cys Leu Pro Leu Tyr Leu Ile Cys Tyr Arg Arg Gln Leu Glu Arg
     530                 535                 540                
 Gln Leu Gln Gln Arg Gln Glu Asp Asp Lys Leu Phe Leu Lys Ile Asn
 545                 550                 555                 560
 Gly Ser Ser Asn Gln Glu Ala Phe Val
                 565                



      <210> 837
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 837
 Met Glu Ser Lys Glu Lys Arg Ala Val Asn Ser Leu Ser Met Glu Asn
   1               5                  10                  15    
 Ala Asn Gln Glu Asn Glu Glu Lys Glu Gln Val Ala Asn Lys Gly Glu
              20                  25                  30        
 Pro Leu Ala Leu Pro Leu Asp Ala Gly Glu Tyr Cys Val Pro Arg Gly
          35                  40                  45            
 Asn Arg Arg Arg Phe Arg Val Arg Gln Pro Ile Leu Gln Tyr Arg Trp
      50                  55                  60                
 Asp Met Met His Arg Leu Gly Glu Pro Gln Ala Arg Met Arg Glu Glu
  65                  70                  75                  80
 Asn Met Glu Arg Ile Gly Glu Glu Val Arg Gln Leu Met Glu Lys Leu
                  85                  90                  95    
 Arg Glu Lys Gln Leu Ser His Ser Leu Arg Ala Val Ser Thr Asp Pro
             100                 105                 110        
 Pro His His Asp His His Asp Glu Phe Cys Leu Met Pro
         115                 120                 125



      <210> 838
      <211> 622
      <212> PRT
      <213> Homo sapiens


      <400> 838
 Met Cys Gly Leu Gln Phe Ser Leu Pro Cys Leu Arg Leu Phe Leu Val
   1               5                  10                  15    
 Val Thr Cys Tyr Leu Leu Leu Leu Leu His Lys Glu Ile Leu Gly Cys
              20                  25                  30        
 Ser Ser Val Cys Gln Leu Cys Thr Gly Arg Gln Ile Asn Cys Arg Asn
          35                  40                  45            
 Leu Gly Leu Ser Ser Ile Pro Lys Asn Phe Pro Glu Ser Thr Val Phe
      50                  55                  60                
 Leu Tyr Leu Thr Gly Asn Asn Ile Ser Tyr Ile Asn Glu Ser Glu Leu
  65                  70                  75                  80
 Thr Gly Leu His Ser Leu Val Ala Leu Tyr Leu Asp Asn Ser Asn Ile
                  85                  90                  95    
 Leu Tyr Val Tyr Pro Lys Ala Phe Val Gln Leu Arg His Leu Tyr Phe
             100                 105                 110        
 Leu Phe Leu Asn Asn Asn Phe Ile Lys Arg Leu Asp Pro Gly Ile Phe
         115                 120                 125            
 Lys Gly Leu Leu Asn Leu Arg Asn Leu Tyr Leu Gln Tyr Asn Gln Val
     130                 135                 140                
 Ser Phe Val Pro Arg Gly Val Phe Asn Asp Leu Val Ser Val Gln Tyr
 145                 150                 155                 160
 Leu Asn Leu Gln Arg Asn Arg Leu Thr Val Leu Gly Ser Gly Thr Phe
                 165                 170                 175    
 Val Gly Met Val Ala Leu Arg Ile Leu Asp Leu Ser Asn Asn Asn Ile
             180                 185                 190        
 Leu Arg Ile Ser Glu Ser Gly Phe Gln His Leu Glu Asn Leu Ala Cys
         195                 200                 205            
 Leu Tyr Leu Gly Ser Asn Asn Leu Thr Lys Val Pro Ser Asn Ala Phe
     210                 215                 220                
 Glu Val Leu Lys Ser Leu Arg Arg Leu Ser Leu Ser His Asn Pro Ile
 225                 230                 235                 240
 Glu Ala Ile Gln Pro Phe Ala Phe Lys Gly Leu Ala Asn Leu Glu Tyr
                 245                 250                 255    
 Leu Leu Leu Lys Asn Ser Arg Ile Arg Asn Val Thr Arg Asp Gly Phe
             260                 265                 270        
 Ser Gly Ile Asn Asn Leu Lys His Leu Ile Leu Ser His Asn Asp Leu
         275                 280                 285            
 Glu Asn Leu Asn Ser Asp Thr Phe Ser Leu Leu Lys Asn Leu Ile Tyr
     290                 295                 300                
 Leu Lys Leu Asp Arg Asn Arg Ile Ile Ser Ile Asp Asn Asp Thr Phe
 305                 310                 315                 320
 Glu Asn Met Gly Ala Ser Leu Lys Ile Leu Asn Leu Ser Phe Asn Asn
                 325                 330                 335    
 Leu Thr Ala Leu His Pro Arg Val Leu Lys Pro Leu Ser Ser Leu Ile
             340                 345                 350        
 His Leu Gln Ala Asn Ser Asn Pro Trp Glu Cys Asn Cys Lys Leu Leu
         355                 360                 365            
 Gly Leu Arg Asp Trp Leu Ala Ser Ser Ala Ile Thr Leu Asn Ile Tyr
     370                 375                 380                
 Cys Gln Asn Pro Pro Ser Met Arg Gly Arg Ala Leu Arg Tyr Ile Asn
 385                 390                 395                 400
 Ile Thr Asn Cys Val Thr Ser Ser Ile Asn Val Ser Arg Ala Trp Ala
                 405                 410                 415    
 Val Val Lys Ser Pro His Ile His His Lys Thr Thr Ala Leu Met Met
             420                 425                 430        
 Ala Trp His Lys Val Thr Thr Asn Gly Ser Pro Leu Glu Asn Thr Glu
         435                 440                 445            
 Thr Glu Asn Ile Thr Phe Trp Glu Arg Ile Pro Thr Ser Pro Ala Gly
     450                 455                 460                
 Arg Phe Phe Gln Glu Asn Ala Phe Gly Asn Pro Leu Glu Thr Thr Ala
 465                 470                 475                 480
 Val Leu Pro Val Gln Ile Gln Leu Thr Thr Ser Val Thr Leu Asn Leu
                 485                 490                 495    
 Glu Lys Asn Ser Ala Leu Pro Asn Asp Ala Ala Ser Met Ser Gly Lys
             500                 505                 510        
 Thr Ser Leu Ile Cys Thr Gln Glu Val Glu Lys Leu Asn Glu Ala Phe
         515                 520                 525            
 Asp Ile Leu Leu Ala Phe Phe Ile Leu Ala Cys Val Leu Ile Ile Phe
     530                 535                 540                
 Leu Ile Tyr Lys Val Val Gln Phe Lys Gln Lys Leu Lys Ala Ser Glu
 545                 550                 555                 560
 Asn Ser Arg Glu Asn Arg Leu Glu Tyr Tyr Ser Phe Tyr Gln Ser Ala
                 565                 570                 575    
 Arg Tyr Asn Val Thr Ala Ser Ile Cys Asn Thr Ser Pro Asn Ser Leu
             580                 585                 590        
 Glu Ser Pro Gly Leu Glu Gln Ile Arg Leu His Lys Gln Ile Val Pro
         595                 600                 605            
 Glu Asn Glu Ala Gln Val Ile Leu Phe Glu His Ser Ala Leu
     610                 615                 620        



      <210> 839
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 839
 Met Val Arg Ile Leu Ala Asn Gly Glu Ile Val Gln Asp Asp Asp Pro
   1               5                  10                  15    
 Arg Val Arg Thr Thr Thr Gln Pro Pro Arg Gly Ser Ile Pro Arg Gln
              20                  25                  30        
 Ser Phe Phe Asn Arg Gly His Gly Ala Pro Pro Gly Gly Pro Gly Pro
          35                  40                  45            
 Arg Gln Gln Gln Ala Gly Ala Arg Leu Gly Ala Ala Gln Ser Pro Phe
      50                  55                  60                
 Asn Asp Leu Asn Arg Gln Leu Val Asn Met Gly Phe Pro Gln Trp His
  65                  70                  75                  80
 Leu Gly Asn His Ala Val Glu Pro Val Thr Ser Ile Leu Leu Leu Phe
                  85                  90                  95    
 Leu Leu Met Met Leu Gly Val Arg Gly Leu Leu Leu Val Gly Leu Val
             100                 105                 110        
 Tyr Leu Val Ser His Leu Ser Gln Arg
         115                 120    



      <210> 840
      <211> 473
      <212> PRT
      <213> Homo sapiens


      <400> 840
 Met Pro Ser Ile Phe Gly Val Lys Asn Lys Gly Asp Gly Lys Ser Ser
   1               5                  10                  15    
 Gly Pro Thr Gly Leu Val Arg Ser Arg Thr His Asp Gly Leu Ala Glu
              20                  25                  30        
 Val Leu Val Leu Glu Ser Gly Arg Lys Glu Glu Pro Arg Gly Gly Gly
          35                  40                  45            
 Asp Ser Gly Gly Gly Gly Gly Gly Arg Pro Asn Pro Gly Pro Pro Arg
      50                  55                  60                
 Ala Ala Gly Pro Gly Gly Gly Ser Leu Ala Ser Ser Ser Val Ala Lys
  65                  70                  75                  80
 Ser His Ser Phe Phe Ser Leu Leu Lys Lys Asn Gly Arg Ser Glu Asn
                  85                  90                  95    
 Gly Lys Gly Glu Pro Val Asp Ala Ser Lys Ala Gly Gly Lys Gln Lys
             100                 105                 110        
 Arg Gly Leu Arg Gly Leu Phe Ser Gly Met Arg Trp His Arg Lys Asp
         115                 120                 125            
 Lys Arg Ala Lys Ala Glu Ala Ala Glu Gly Arg Ala Pro Gly Gly Gly
     130                 135                 140                
 Leu Ile Leu Pro Gly Ser Leu Thr Ala Ser Leu Glu Cys Val Lys Glu
 145                 150                 155                 160
 Glu Thr Pro Arg Ala Ala Arg Glu Pro Glu Glu Pro Ser Gln Asp Ala
                 165                 170                 175    
 Pro Arg Asp Pro Ala Gly Cys Gly Asp Ile Ile Ala Asp Gln Glu Glu
             180                 185                 190        
 Glu Ala Gly Pro Ser Cys Asp Lys His Val Pro Gly Pro Gly Lys Pro
         195                 200                 205            
 Ala Leu Ser Lys Lys Asn Pro Gly Val Val Ala Tyr Gln Gly Gly Gly
     210                 215                 220                
 Glu Glu Met Ala Ser Pro Asp Glu Val Asp Asp Thr Tyr Leu Gln Glu
 225                 230                 235                 240
 Phe Trp Asp Met Leu Ser Gln Thr Glu Glu Gln Gly Pro Glu Pro Gln
                 245                 250                 255    
 Glu Gly Ala Ala Lys Val Ala Ala Ala Leu Glu Thr Lys Val Val Pro
             260                 265                 270        
 Glu Thr Pro Lys Asp Thr Arg Cys Val Glu Ala Ala Lys Asp Ala Ser
         275                 280                 285            
 Ser Val Lys Arg Arg Arg Leu Asn Arg Ile Pro Ile Glu Pro His Pro
     290                 295                 300                
 Lys Glu Glu Pro Lys His Pro Glu Lys Glu Gln Gln Glu Gly Val Pro
 305                 310                 315                 320
 Asn Ser Asp Glu Gly Tyr Trp Asp Ser Thr Thr Pro Gly Pro Glu Glu
                 325                 330                 335    
 Asp Ser Ser Ser Ser Gly Lys Lys Ala Gly Ile Pro Arg Asp Ser Tyr
             340                 345                 350        
 Ser Gly Asp Ala Leu Tyr Asp Leu Tyr Ala Asp Pro Asp Gly Ser Pro
         355                 360                 365            
 Ala Thr Leu Pro Gly Gly Lys Asp Asn Glu Glu Thr Ser Ser Leu Ser
     370                 375                 380                
 Arg Leu Lys Pro Val Ser Pro Gly Thr Ile Thr Cys Pro Leu Arg Thr
 385                 390                 395                 400
 Pro Gly Ser Leu Leu Lys Asp Ser Lys Ile Pro Ile Ser Ile Lys His
                 405                 410                 415    
 Leu Thr Asn Leu Pro Ser Ser His Pro Val Val His Gln Gln Pro Ser
             420                 425                 430        
 Arg Ser Glu Met Pro Arg Thr Lys Ile Pro Val Ser Lys Val Leu Val
         435                 440                 445            
 Arg Arg Val Ser Asn Arg Gly Leu Ala Gly Thr Thr Ile Arg Ala Thr
     450                 455                 460                
 Ala Cys His Asp Ser Ala Lys Lys Leu
 465                 470            



      <210> 841
      <211> 691
      <212> PRT
      <213> Homo sapiens


      <400> 841
 Met Ala Ala Ile Gln His Gly His Glu Ala Val Val Arg Leu Leu Met
   1               5                  10                  15    
 Glu Trp Gly Ala Asp Pro Asn His Ala Ala Arg Thr Val Gly Trp Ser
              20                  25                  30        
 Pro Leu Met Leu Ala Ala Leu Thr Gly Arg Leu Gly Val Ala Gln Gln
          35                  40                  45            
 Leu Val Glu Lys Gly Ala Asn Pro Asp His Leu Ser Val Leu Glu Lys
      50                  55                  60                
 Thr Ala Phe Glu Val Ala Leu Asp Cys Lys His Arg Asp Leu Val Asp
  65                  70                  75                  80
 Tyr Leu Asp Pro Leu Thr Thr Val Arg Pro Lys Thr Asp Glu Glu Lys
                  85                  90                  95    
 Arg Arg Pro Asp Ile Phe His Ala Leu Lys Met Gly Asn Phe Gln Leu
             100                 105                 110        
 Val Lys Glu Ile Ala Asp Glu Asp Pro Ser His Val Asn Leu Val Asn
         115                 120                 125            
 Gly Asp Gly Ala Thr Pro Leu Met Leu Ala Ala Val Thr Gly Gln Leu
     130                 135                 140                
 Ala Leu Val Gln Leu Leu Val Glu Arg His Ala Asp Val Asp Lys Gln
 145                 150                 155                 160
 Asp Ser Val His Gly Trp Thr Ala Leu Met Gln Ala Thr Tyr His Gly
                 165                 170                 175    
 Asn Lys Glu Ile Val Lys Tyr Leu Leu Asn Gln Gly Ala Asp Val Thr
             180                 185                 190        
 Leu Arg Ala Lys Asn Gly Tyr Thr Ala Phe Asp Leu Val Met Leu Leu
         195                 200                 205            
 Asn Asp Pro Asp Thr Glu Leu Val Arg Leu Leu Ala Ser Val Cys Met
     210                 215                 220                
 Gln Val Asn Lys Asp Lys Gly Arg Pro Ser His Gln Pro Pro Leu Pro
 225                 230                 235                 240
 His Ser Lys Val Arg Gln Pro Trp Ser Ile Pro Val Leu Pro Asp Asp
                 245                 250                 255    
 Lys Gly Gly Leu Lys Ser Trp Trp Asn Arg Met Ser Asn Arg Phe Arg
             260                 265                 270        
 Lys Leu Lys Leu Met Gln Thr Leu Pro Arg Gly Leu Ser Ser Asn Gln
         275                 280                 285            
 Pro Leu Pro Phe Ser Asp Glu Pro Glu Pro Ala Leu Asp Ser Thr Met
     290                 295                 300                
 Arg Ala Ala Pro Gln Asp Lys Thr Ser Arg Ser Ala Leu Pro Asp Ala
 305                 310                 315                 320
 Ala Pro Val Thr Lys Asp Asn Gly Pro Gly Ser Thr Arg Gly Glu Lys
                 325                 330                 335    
 Glu Asp Thr Leu Leu Thr Thr Met Leu Arg Asn Gly Ala Pro Leu Thr
             340                 345                 350        
 Arg Leu Pro Ser Asp Lys Leu Lys Ala Val Ile Pro Pro Phe Leu Pro
         355                 360                 365            
 Pro Ser Ser Phe Glu Leu Trp Ser Ser Asp Arg Ser Arg Thr Arg His
     370                 375                 380                
 Asn Gly Lys Ala Asp Pro Met Lys Thr Ala Leu Pro Gln Arg Ala Ser
 385                 390                 395                 400
 Arg Gly His Pro Val Gly Gly Gly Gly Thr Asp Thr Thr Pro Val Arg
                 405                 410                 415    
 Pro Val Lys Phe Pro Ser Leu Pro Arg Ser Pro Ala Ser Ser Ala Asn
             420                 425                 430        
 Ser Gly Asn Phe Asn His Ser Pro His Ser Ser Gly Gly Ser Ser Gly
         435                 440                 445            
 Ile Gly Val Ser Arg His Gly Gly Glu Leu Leu Asn Arg Ser Gly Gly
     450                 455                 460                
 Ser Ile Asp Asn Val Leu Ser Gln Ile Ala Ala Gln Arg Lys Lys Ala
 465                 470                 475                 480
 Ala Gly Leu Leu Glu Gln Lys Pro Ser His Arg Ser Ser Pro Val Gly
                 485                 490                 495    
 Pro Ala Pro Gly Ser Ser Pro Ser Glu Leu Pro Ala Ser Pro Ala Gly
             500                 505                 510        
 Gly Ser Ala Pro Val Gly Lys Gln Lys Leu Glu Thr Ser Lys Arg Pro
         515                 520                 525            
 Pro Ser Gly Thr Ser Thr Thr Ser Lys Ser Thr Ser Pro Thr Leu Thr
     530                 535                 540                
 Pro Ser Pro Ser Pro Lys Gly His Thr Ala Glu Ser Ser Val Ser Ser
 545                 550                 555                 560
 Ser Ser Ser His Arg Gln Ser Lys Ser Ser Gly Gly Ser Ser Ser Gly
                 565                 570                 575    
 Thr Ile Thr Asp Glu Asp Glu Leu Thr Gly Ile Leu Lys Lys Leu Ser
             580                 585                 590        
 Leu Glu Lys Tyr Gln Pro Ile Phe Glu Glu Gln Glu Val Asp Met Glu
         595                 600                 605            
 Ala Phe Leu Thr Leu Thr Asp Gly Asp Leu Lys Glu Leu Gly Ile Lys
     610                 615                 620                
 Thr Asp Gly Ser Arg Gln Gln Ile Leu Ala Ala Ile Ser Glu Leu Asn
 625                 630                 635                 640
 Ala Gly Lys Gly Arg Glu Arg Gln Ile Leu Gln Glu Thr Ile His Asn
                 645                 650                 655    
 Phe His Ser Ser Phe Glu Ser Ser Ala Ser Asn Thr Arg Ala Pro Gly
             660                 665                 670        
 Asn Ser Pro Ser Met Val Gly Trp Val Arg Pro Glu Glu Thr Ala Ser
         675                 680                 685            
 Gly Lys Arg
     690    



      <210> 842
      <211> 348
      <212> PRT
      <213> Homo sapiens


      <400> 842
 Met Gly Ser Trp Val Gln Leu Ile Thr Ser Val Gly Val Gln Gln Asn
   1               5                  10                  15    
 His Pro Gly Trp Thr Val Ala Gly Gln Phe Gln Glu Lys Lys Arg Phe
              20                  25                  30        
 Thr Glu Glu Val Ile Glu Tyr Phe Gln Lys Lys Val Ser Pro Val His
          35                  40                  45            
 Leu Lys Ile Leu Leu Thr Ser Asp Glu Ala Trp Lys Arg Phe Val Arg
      50                  55                  60                
 Val Ala Glu Leu Pro Arg Glu Glu Ala Asp Ala Leu Tyr Glu Ala Leu
  65                  70                  75                  80
 Lys Asn Leu Thr Pro Tyr Val Ala Ile Glu Asp Lys Asp Met Gln Gln
                  85                  90                  95    
 Lys Glu Gln Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Ile
             100                 105                 110        
 Arg Trp Lys Ile Gln Glu Ser Ile Glu Arg Leu Arg Val Ile Ala Asn
         115                 120                 125            
 Glu Ile Glu Lys Val His Arg Gly Cys Val Ile Ala Asn Val Val Ser
     130                 135                 140                
 Gly Ser Thr Gly Ile Leu Ser Val Ile Gly Val Met Leu Ala Pro Phe
 145                 150                 155                 160
 Thr Ala Gly Leu Ser Leu Ser Ile Thr Ala Ala Gly Val Gly Leu Gly
                 165                 170                 175    
 Ile Ala Ser Ala Thr Ala Gly Ile Ala Ser Ser Ile Val Glu Asn Thr
             180                 185                 190        
 Tyr Thr Arg Ser Ala Glu Leu Thr Ala Ser Arg Leu Thr Ala Thr Ser
         195                 200                 205            
 Thr Asp Gln Leu Glu Ala Leu Arg Asp Ile Leu Arg Asp Ile Thr Pro
     210                 215                 220                
 Asn Val Leu Ser Phe Ala Leu Asp Phe Asp Glu Ala Thr Lys Met Ile
 225                 230                 235                 240
 Ala Asn Asp Val His Thr Leu Arg Arg Ser Lys Ala Thr Val Gly Arg
                 245                 250                 255    
 Pro Leu Ile Ala Trp Arg Tyr Val Pro Ile Asn Val Val Glu Thr Leu
             260                 265                 270        
 Arg Thr Arg Gly Ala Pro Thr Arg Ile Val Arg Lys Val Ala Arg Asn
         275                 280                 285            
 Leu Gly Lys Ala Thr Ser Gly Val Leu Val Val Leu Asp Val Val Asn
     290                 295                 300                
 Leu Val Gln Asp Ser Leu Asp Leu His Lys Gly Ala Lys Ser Glu Ser
 305                 310                 315                 320
 Ala Glu Ser Leu Arg Gln Trp Ala Gln Glu Leu Glu Glu Asn Leu Asn
                 325                 330                 335    
 Glu Leu Thr His Ile His Gln Ser Leu Lys Ala Gly
             340                 345            



      <210> 843
      <211> 348
      <212> PRT
      <213> Homo sapiens


      <400> 843
 Met Gly Ser Trp Val Gln Leu Ile Thr Ser Val Gly Val Gln Gln Asn
   1               5                  10                  15    
 His Pro Gly Trp Thr Val Ala Gly Gln Phe Gln Glu Lys Lys Arg Phe
              20                  25                  30        
 Thr Glu Glu Val Ile Glu Tyr Phe Gln Lys Lys Val Ser Pro Val His
          35                  40                  45            
 Leu Lys Ile Leu Leu Thr Ser Asp Glu Ala Trp Lys Arg Phe Val Arg
      50                  55                  60                
 Val Ala Glu Leu Pro Arg Glu Glu Ala Asp Ala Leu Tyr Glu Ala Leu
  65                  70                  75                  80
 Lys Asn Leu Thr Pro Tyr Val Ala Ile Glu Asp Lys Asp Met Gln Gln
                  85                  90                  95    
 Lys Glu Gln Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Ile
             100                 105                 110        
 Arg Trp Lys Ile Gln Glu Ser Ile Glu Arg Leu Arg Val Ile Ala Asn
         115                 120                 125            
 Glu Ile Glu Lys Val His Arg Gly Cys Val Ile Ala Asn Val Val Ser
     130                 135                 140                
 Gly Ser Thr Gly Ile Leu Ser Val Ile Gly Val Met Leu Ala Pro Phe
 145                 150                 155                 160
 Thr Ala Gly Leu Ser Leu Ser Ile Thr Ala Ala Gly Val Gly Leu Gly
                 165                 170                 175    
 Ile Ala Ser Ala Thr Ala Gly Ile Ala Ser Ser Ile Val Glu Asn Thr
             180                 185                 190        
 Tyr Thr Arg Ser Ala Glu Leu Thr Ala Ser Arg Leu Thr Ala Thr Ser
         195                 200                 205            
 Thr Asp Gln Leu Glu Ala Leu Arg Asp Ile Leu His Asp Ile Thr Pro
     210                 215                 220                
 Asn Val Leu Ser Phe Ala Leu Asp Phe Asp Glu Ala Thr Lys Met Ile
 225                 230                 235                 240
 Ala Asn Asp Val His Thr Leu Arg Arg Ser Lys Ala Thr Val Gly Arg
                 245                 250                 255    
 Pro Leu Ile Ala Trp Arg Tyr Val Pro Ile Asn Val Val Glu Thr Leu
             260                 265                 270        
 Arg Thr Arg Gly Ala Pro Thr Arg Ile Val Arg Lys Val Ala Arg Asn
         275                 280                 285            
 Leu Gly Lys Ala Thr Ser Gly Val Leu Val Val Leu Asp Val Val Asn
     290                 295                 300                
 Leu Val Gln Asp Ser Leu Asp Leu His Lys Gly Ala Lys Ser Glu Ser
 305                 310                 315                 320
 Ala Glu Ser Leu Arg Gln Trp Ala Gln Glu Leu Glu Glu Asn Leu Asn
                 325                 330                 335    
 Glu Leu Thr His Ile His Gln Ser Leu Lys Ala Gly
             340                 345            



      <210> 844
      <211> 458
      <212> PRT
      <213> Homo sapiens


      <400> 844
 Met Glu Val Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys
   1               5                  10                  15    
 Arg Gly Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala
              20                  25                  30        
 Gly Gln Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr
          35                  40                  45            
 Thr Ile Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly
      50                  55                  60                
 His Pro Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser
  65                  70                  75                  80
 Asp Lys Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu
                  85                  90                  95    
 Arg Ile Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn
             100                 105                 110        
 Gly Val Gly Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr
         115                 120                 125            
 Leu Asp Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg
     130                 135                 140                
 Gly Asn Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn
 145                 150                 155                 160
 Ser Asn Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu
                 165                 170                 175    
 Ser His Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr
             180                 185                 190        
 Gln Gly Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp
         195                 200                 205            
 Tyr Ala Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile
     210                 215                 220                
 Pro Asp Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro
 225                 230                 235                 240
 Ala Leu Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu
                 245                 250                 255    
 Asn Val Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln
             260                 265                 270        
 Leu Gln Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala
         275                 280                 285            
 Gln Gly Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly
     290                 295                 300                
 Tyr Tyr Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys
 305                 310                 315                 320
 Thr Val Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile
                 325                 330                 335    
 Thr Pro Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp
             340                 345                 350        
 Leu Lys Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr
         355                 360                 365            
 Tyr Gln Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu
     370                 375                 380                
 Leu Val Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu
 385                 390                 395                 400
 Glu Leu Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met
                 405                 410                 415    
 Ala Ser Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn
             420                 425                 430        
 Ile Ser Ser Glu Thr Gly Gly Gln Leu Glu Gly His Cys Gly Asn Val
         435                 440                 445            
 Arg Gly Val Glu Arg Pro Thr Asp Arg Arg
     450                 455            



      <210> 845
      <211> 955
      <212> PRT
      <213> Homo sapiens


      <400> 845
 Met Glu Val Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys
   1               5                  10                  15    
 Arg Gly Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala
              20                  25                  30        
 Gly Gln Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr
          35                  40                  45            
 Thr Ile Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly
      50                  55                  60                
 His Pro Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser
  65                  70                  75                  80
 Asp Lys Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu
                  85                  90                  95    
 Arg Ile Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn
             100                 105                 110        
 Gly Val Gly Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr
         115                 120                 125            
 Leu Asp Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg
     130                 135                 140                
 Gly Asn Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn
 145                 150                 155                 160
 Ser Asn Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu
                 165                 170                 175    
 Ser His Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr
             180                 185                 190        
 Gln Gly Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp
         195                 200                 205            
 Tyr Ala Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile
     210                 215                 220                
 Pro Asp Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro
 225                 230                 235                 240
 Ala Leu Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu
                 245                 250                 255    
 Asn Val Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln
             260                 265                 270        
 Leu Gln Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala
         275                 280                 285            
 Gln Gly Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly
     290                 295                 300                
 Tyr Tyr Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys
 305                 310                 315                 320
 Thr Val Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile
                 325                 330                 335    
 Thr Pro Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp
             340                 345                 350        
 Leu Lys Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr
         355                 360                 365            
 Tyr Gln Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu
     370                 375                 380                
 Leu Val Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu
 385                 390                 395                 400
 Glu Leu Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met
                 405                 410                 415    
 Ala Ser Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn
             420                 425                 430        
 Ile Ser Ser Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg
         435                 440                 445            
 Ala Val Val Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu
     450                 455                 460                
 Val Arg Gly Lys Pro Arg Pro Pro Val Leu Trp Ser Arg Val Asp Lys
 465                 470                 475                 480
 Glu Ala Ala Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu Thr Pro Asp
                 485                 490                 495    
 Gly Lys Leu Arg Leu Glu Arg Val Ser Arg Asp Met Ser Gly Thr Tyr
             500                 505                 510        
 Arg Cys Gln Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg Pro Arg Glu
         515                 520                 525            
 Ala Gln Val Gln Leu Asn Val Gln Phe Pro Pro Glu Val Glu Pro Ser
     530                 535                 540                
 Ser Gln Asp Val Arg Gln Ala Leu Gly Arg Pro Val Leu Leu Arg Cys
 545                 550                 555                 560
 Ser Leu Leu Arg Gly Ser Pro Gln Arg Ile Ala Ser Ala Val Trp Arg
                 565                 570                 575    
 Phe Lys Gly Gln Leu Leu Pro Pro Pro Pro Val Val Pro Ala Ala Ala
             580                 585                 590        
 Glu Ala Pro Asp His Ala Glu Leu Arg Leu Asp Ala Val Thr Arg Asp
         595                 600                 605            
 Ser Ser Gly Ser Tyr Glu Cys Ser Val Ser Asn Asp Val Gly Ser Ala
     610                 615                 620                
 Ala Cys Leu Phe Gln Val Ser Ala Lys Ala Tyr Ser Pro Glu Phe Tyr
 625                 630                 635                 640
 Phe Asp Thr Pro Asn Pro Thr Arg Ser His Lys Leu Ser Lys Asn Tyr
                 645                 650                 655    
 Ser Tyr Val Leu Gln Trp Thr Gln Arg Glu Pro Asp Ala Val Asp Pro
             660                 665                 670        
 Val Leu Asn Tyr Arg Leu Ser Ile Arg Gln Leu Asn Gln His Asn Ala
         675                 680                 685            
 Val Val Lys Ala Ile Pro Val Arg Arg Val Glu Lys Gly Gln Leu Leu
     690                 695                 700                
 Glu Tyr Ile Leu Thr Asp Leu Arg Val Pro His Ser Tyr Glu Val Arg
 705                 710                 715                 720
 Leu Thr Pro Tyr Thr Thr Phe Gly Ala Gly Asp Met Ala Ser Arg Ile
                 725                 730                 735    
 Ile His Tyr Thr Glu Pro Ile Asn Ser Pro Asn Leu Ser Asp Asn Thr
             740                 745                 750        
 Cys His Phe Glu Asp Glu Lys Ile Cys Gly Tyr Thr Gln Asp Leu Thr
         755                 760                 765            
 Asp Asn Phe Asp Trp Thr Arg Gln Asn Ala Leu Thr Gln Asn Pro Lys
     770                 775                 780                
 Arg Ser Pro Asn Thr Gly Pro Pro Thr Asp Ile Ser Gly Thr Pro Glu
 785                 790                 795                 800
 Gly Tyr Tyr Met Phe Ile Glu Thr Ser Arg Pro Arg Glu Leu Gly Asp
                 805                 810                 815    
 Arg Ala Arg Leu Val Ser Pro Leu Tyr Asn Ala Ser Ala Lys Phe Tyr
             820                 825                 830        
 Cys Val Ser Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu
         835                 840                 845            
 Asn Leu Leu Val Arg Ser Arg Asn Lys Gly Ala Leu Asp Thr His Ala
     850                 855                 860                
 Trp Ser Leu Ser Gly Asn Lys Gly Asn Val Trp Gln Gln Ala His Val
 865                 870                 875                 880
 Pro Ile Ser Pro Ser Gly Pro Phe Gln Ile Ile Phe Glu Gly Val Arg
                 885                 890                 895    
 Gly Pro Gly Tyr Leu Gly Asp Ile Ala Ile Asp Asp Val Thr Leu Lys
             900                 905                 910        
 Lys Gly Glu Cys Pro Arg Lys Gln Thr Asp Pro Asn Lys Val Val Val
         915                 920                 925            
 Met Pro Gly Ser Gly Ala Pro Cys Gln Ser Ser Pro Gln Leu Trp Gly
     930                 935                 940                
 Pro Met Ala Ile Phe Leu Leu Ala Leu Gln Arg
 945                 950                 955



      <210> 846
      <211> 516
      <212> PRT
      <213> Homo sapiens


      <400> 846
 Met Glu Arg Glu Pro Gly Ala Ala Gly Val Arg Arg Ala Leu Gly Arg
   1               5                  10                  15    
 Arg Leu Glu Ala Val Leu Ala Ser Arg Ser Glu Ala Asn Ala Val Phe
              20                  25                  30        
 Asp Ile Leu Ala Val Leu Gln Ser Glu Asp Gln Glu Glu Ile Gln Glu
          35                  40                  45            
 Ala Val Arg Thr Cys Ser Arg Leu Phe Gly Ala Leu Leu Glu Arg Gly
      50                  55                  60                
 Glu Leu Phe Val Gly Gln Leu Pro Ser Glu Glu Met Val Met Thr Gly
  65                  70                  75                  80
 Ser Gln Gly Ala Thr Arg Lys Tyr Lys Val Trp Met Arg His Arg Tyr
                  85                  90                  95    
 His Ser Cys Cys Asn Arg Leu Gly Glu Leu Leu Gly His Pro Ser Phe
             100                 105                 110        
 Gln Val Lys Glu Leu Ala Leu Ser Ala Leu Leu Lys Phe Val Gln Leu
         115                 120                 125            
 Glu Gly Ala His Pro Leu Glu Lys Ser Lys Trp Glu Gly Asn Tyr Leu
     130                 135                 140                
 Phe Pro Arg Glu Leu Phe Lys Leu Val Val Gly Gly Leu Leu Ser Pro
 145                 150                 155                 160
 Glu Glu Asp Gln Ser Leu Leu Leu Ser Gln Phe Arg Glu Tyr Leu Asp
                 165                 170                 175    
 Tyr Asp Asp Thr Arg Tyr His Thr Met Gln Ala Ala Val Asp Ala Val
             180                 185                 190        
 Ala Arg Val Thr Gly Gln His Pro Glu Val Pro Pro Ala Phe Trp Asn
         195                 200                 205            
 Asn Ala Phe Thr Leu Leu Ser Ala Val Ser Leu Pro Arg Arg Glu Pro
     210                 215                 220                
 Thr Val Ser Ser Phe Tyr Val Lys Arg Ala Glu Leu Trp Asp Thr Trp
 225                 230                 235                 240
 Lys Val Ala His Leu Lys Glu His Arg Arg Val Phe Gln Ala Met Trp
                 245                 250                 255    
 Leu Ser Phe Leu Lys His Lys Leu Pro Leu Ser Leu Tyr Lys Lys Val
             260                 265                 270        
 Leu Leu Ile Val His Asp Ala Ile Leu Pro Gln Leu Ala Gln Pro Thr
         275                 280                 285            
 Leu Met Ile Asp Phe Leu Thr Arg Ala Cys Asp Leu Gly Gly Ala Leu
     290                 295                 300                
 Ser Leu Leu Ala Leu Asn Gly Leu Phe Ile Leu Ile His Lys His Asn
 305                 310                 315                 320
 Leu Glu Tyr Pro Asp Phe Tyr Arg Lys Leu Tyr Gly Leu Leu Asp Pro
                 325                 330                 335    
 Ser Val Phe His Val Lys Tyr Arg Ala Arg Phe Phe His Leu Ala Asp
             340                 345                 350        
 Leu Phe Leu Ser Ser Ser His Leu Pro Ala Tyr Leu Val Ala Ala Phe
         355                 360                 365            
 Ala Lys Arg Leu Ala Arg Leu Ala Leu Thr Ala Pro Pro Glu Ala Leu
     370                 375                 380                
 Leu Met Val Leu Pro Phe Ile Cys Asn Leu Leu Arg Arg His Pro Ala
 385                 390                 395                 400
 Cys Arg Val Leu Val His Arg Pro His Gly Pro Glu Leu Asp Ala Asp
                 405                 410                 415    
 Pro Tyr Asp Pro Gly Glu Glu Asp Pro Ala Gln Ser Arg Ala Leu Glu
             420                 425                 430        
 Ser Ser Leu Trp Glu Leu Gln Ala Leu Gln Arg His Tyr His Pro Glu
         435                 440                 445            
 Val Ser Lys Ala Ala Ser Val Ile Asn Gln Ala Leu Ser Met Pro Glu
     450                 455                 460                
 Val Ser Ile Ala Pro Leu Leu Glu Leu Thr Ala Tyr Glu Ile Phe Glu
 465                 470                 475                 480
 Arg Asp Leu Lys Lys Lys Gly Pro Glu Pro Val Pro Leu Glu Phe Ile
                 485                 490                 495    
 Pro Ala Gln Gly Leu Leu Gly Arg Pro Gly Glu Leu Cys Ala Gln His
             500                 505                 510        
 Phe Thr Leu Ser
         515    



      <210> 847
      <211> 1600
      <212> PRT
      <213> Homo sapiens


      <400> 847
 Met His Asp Ala Phe Glu Pro Val Pro Ile Leu Glu Lys Leu Pro Leu
   1               5                  10                  15    
 Gln Ile Asp Cys Leu Ala Ala Trp Glu Glu Trp Leu Leu Val Gly Thr
              20                  25                  30        
 Lys Gln Gly His Leu Leu Leu Tyr Arg Ile Arg Lys Asp Val Val Pro
          35                  40                  45            
 Ala Asp Val Ala Ser Pro Glu Ser Gly Ser Cys Asn Arg Phe Glu Val
      50                  55                  60                
 Thr Leu Glu Lys Ser Asn Lys Asn Phe Ser Lys Lys Ile Gln Gln His
  65                  70                  75                  80
 Thr Glu Thr Gly Glu Glu Val Leu Arg Met Cys Val Ala Val Lys Lys
                  85                  90                  95    
 Lys Leu Gln Leu Tyr Phe Trp Lys Asp Arg Glu Phe His Glu Leu Gln
             100                 105                 110        
 Val Asp Gly Lys Gly Ser Ile Lys Glu Leu Phe Pro Thr Gly Lys Gln
         115                 120                 125            
 Leu Glu Pro Leu Val Ala Pro Leu Ala Asp Gly Lys Val Ala Val Gly
     130                 135                 140                
 Gln Asp Asp Leu Thr Val Val Leu Asn Glu Glu Gly Ile Cys Thr Gln
 145                 150                 155                 160
 Lys Cys Ala Leu Asn Trp Thr Asp Ile Pro Val Ala Met Glu His Gln
                 165                 170                 175    
 Pro Pro Tyr Ile Ile Ala Val Leu Pro Arg Tyr Val Glu Ile Arg Thr
             180                 185                 190        
 Phe Glu Pro Arg Leu Leu Val Gln Ser Ile Glu Leu Gln Arg Pro Arg
         195                 200                 205            
 Phe Ile Thr Ser Gly Gly Ser Asn Ile Ile Tyr Val Ala Ser Asn His
     210                 215                 220                
 Phe Val Trp Arg Leu Ile Pro Val Pro Met Ala Thr Gln Ile Gln Gln
 225                 230                 235                 240
 Leu Leu Gln Asp Lys Gln Phe Glu Leu Ala Leu Gln Leu Ala Glu Met
                 245                 250                 255    
 Lys Asp Asp Ser Asp Ser Glu Lys Gln Gln Gln Ile His His Ile Lys
             260                 265                 270        
 Asn Leu Tyr Ala Phe Asn Leu Phe Cys Gln Lys Arg Phe Asp Glu Ser
         275                 280                 285            
 Met Gln Val Phe Ala Lys Leu Gly Thr Asp Tyr Arg Lys Gln Leu Gln
     290                 295                 300                
 Tyr Pro Asn Pro Leu Pro Val Leu Ser Gly Ala Glu Leu Glu Lys Ala
 305                 310                 315                 320
 His Leu Ala Leu Ile Asp Tyr Leu Thr Gln Lys Arg Ser Gln Leu Val
                 325                 330                 335    
 Lys Lys Leu Asn Asp Ser Asp His Gln Ser Ser Thr Ser Pro Leu Met
             340                 345                 350        
 Glu Gly Thr Pro Thr Ile Lys Ser Lys Lys Lys Leu Leu Gln Ile Ile
         355                 360                 365            
 Asp Thr Thr Leu Leu Lys Cys Tyr Leu His Thr Asn Val Ala Leu Val
     370                 375                 380                
 Ala Pro Leu Leu Arg Leu Glu Asn Asn His Cys His Ile Glu Glu Ser
 385                 390                 395                 400
 Glu His Val Leu Lys Lys Ala His Lys Tyr Ser Glu Leu Ile Ile Leu
                 405                 410                 415    
 Tyr Glu Lys Lys Gly Leu His Glu Lys Ala Leu Gln Val Leu Val Asp
             420                 425                 430        
 Gln Ser Lys Lys Ala Asn Ser Pro Leu Lys Gly His Glu Arg Thr Val
         435                 440                 445            
 Gln Tyr Leu Gln His Leu Gly Thr Glu Asn Leu His Leu Ile Phe Ser
     450                 455                 460                
 Tyr Ser Val Trp Val Leu Arg Asp Phe Pro Glu Asp Gly Leu Lys Ile
 465                 470                 475                 480
 Phe Thr Glu Asp Leu Pro Glu Val Glu Ser Leu Pro Arg Asp Arg Val
                 485                 490                 495    
 Leu Gly Phe Leu Ile Glu Asn Phe Lys Gly Leu Ala Ile Pro Tyr Leu
             500                 505                 510        
 Glu His Ile Ile His Val Trp Glu Glu Thr Gly Ser Arg Phe His Asn
         515                 520                 525            
 Cys Leu Ile Gln Leu Tyr Cys Glu Lys Val Gln Gly Leu Met Lys Glu
     530                 535                 540                
 Tyr Leu Leu Ser Phe Pro Ala Gly Lys Thr Pro Val Pro Ala Gly Glu
 545                 550                 555                 560
 Glu Glu Gly Glu Leu Gly Glu Tyr Arg Gln Lys Leu Leu Met Phe Leu
                 565                 570                 575    
 Glu Ile Ser Ser Tyr Tyr Asp Pro Gly Arg Leu Ile Cys Asp Phe Pro
             580                 585                 590        
 Phe Asp Gly Leu Leu Glu Glu Arg Ala Leu Leu Leu Gly Arg Met Gly
         595                 600                 605            
 Lys His Glu Gln Ala Leu Phe Ile Tyr Val His Ile Leu Lys Asp Thr
     610                 615                 620                
 Arg Met Ala Glu Glu Tyr Cys His Lys His Tyr Asp Arg Asn Lys Asp
 625                 630                 635                 640
 Gly Asn Lys Asp Val Tyr Leu Ser Leu Leu Arg Met Tyr Leu Ser Pro
                 645                 650                 655    
 Pro Ser Ile His Cys Leu Gly Pro Ile Lys Leu Glu Leu Leu Glu Pro
             660                 665                 670        
 Lys Ala Asn Leu Gln Ala Ala Leu Gln Val Leu Glu Leu His His Ser
         675                 680                 685            
 Lys Leu Asp Thr Thr Lys Ala Leu Asn Leu Leu Pro Ala Asn Thr Gln
     690                 695                 700                
 Ile Asn Asp Ile Arg Ile Phe Leu Glu Lys Val Leu Glu Glu Asn Ala
 705                 710                 715                 720
 Gln Lys Lys Arg Phe Asn Gln Val Leu Lys Asn Leu Leu His Ala Glu
                 725                 730                 735    
 Phe Leu Arg Val Gln Glu Glu Arg Ile Leu His Gln Gln Val Lys Cys
             740                 745                 750        
 Ile Ile Thr Glu Glu Lys Val Cys Met Val Cys Lys Lys Lys Ile Gly
         755                 760                 765            
 Asn Ser Ala Phe Ala Arg Tyr Pro Asn Gly Val Val Val His Tyr Phe
     770                 775                 780                
 Cys Ser Lys Glu Arg Glu Thr Tyr Pro Tyr Tyr Asp Leu Gln Val Lys
 785                 790                 795                 800
 Val Leu Arg Ala Thr Asn Ile Arg Gly Thr Asp Leu Leu Ser Lys Ala
                 805                 810                 815    
 Asp Cys Tyr Val Gln Leu Trp Leu Pro Thr Ala Ser Pro Ser Pro Ala
             820                 825                 830        
 Gln Thr Arg Ile Val Ala Asn Cys Ser Asp Pro Glu Trp Asn Glu Thr
         835                 840                 845            
 Phe His Tyr Gln Ile His Gly Ala Val Lys Asn Val Leu Glu Leu Thr
     850                 855                 860                
 Leu Tyr Asp Lys Asp Ile Leu Gly Ser Asp Gln Leu Ser Leu Leu Leu
 865                 870                 875                 880
 Phe Asp Leu Arg Ser Leu Lys Cys Gly Gln Pro His Lys His Thr Phe
                 885                 890                 895    
 Pro Leu Asn His Gln Asp Ser Gln Glu Leu Gln Val Glu Phe Val Leu
             900                 905                 910        
 Glu Lys Ser Gln Val Pro Ala Ser Glu Val Ile Thr Asn Gly Val Leu
         915                 920                 925            
 Val Ala His Pro Cys Leu Arg Ile Gln Gly Thr Leu Arg Gly Asp Gly
     930                 935                 940                
 Thr Ala Pro Arg Glu Glu Tyr Gly Ser Arg Gln Leu Gln Leu Ala Val
 945                 950                 955                 960
 Pro Gly Ala Tyr Glu Lys Pro Gln Leu Leu Pro Leu Gln Pro Pro Thr
                 965                 970                 975    
 Glu Pro Gly Leu Pro Pro Thr Phe Thr Phe His Val Asn Pro Val Leu
             980                 985                 990        
 Ser Ser Arg Leu His Val Glu Leu Met Glu Leu Leu Ala Ala Val Gln
         995                1000                1005            
 Ser Gly Pro Ser Ala Glu Leu Glu Ala Gln Thr Ser Lys Leu Gly Glu
    1010                1015                1020                
 Gly Gly Ile Leu Leu Ser Ser Leu Pro Leu Gly Gln Glu Glu Gln Cys
1025                1030                1035                1040
 Ser Val Ala Leu Gly Glu Gly Glu Gly Val Ala Leu Ser Met Thr Val
                1045                1050                1055    
 Glu Met Ser Ser Gly Asp Leu Asp Leu Arg Leu Gly Phe Asp Leu Ser
            1060                1065                1070        
 Asp Gly Glu Gln Glu Phe Leu Asp Arg Arg Lys Gln Val Val Ser Lys
        1075                1080                1085            
 Ala Leu Gln Gln Val Leu Gly Leu Ser Glu Ala Leu Asp Ser Gly Gln
    1090                1095                1100                
 Val Pro Val Val Ala Val Leu Gly Ser Gly Gly Gly Thr Arg Ala Met
1105                1110                1115                1120
 Ser Ser Leu Tyr Gly Ser Leu Ala Gly Leu Gln Glu Leu Gly Leu Leu
                1125                1130                1135    
 Asp Thr Val Thr Tyr Leu Ser Gly Val Ser Gly Ser Thr Trp Cys Ile
            1140                1145                1150        
 Ser Thr Leu Tyr Arg Asp Pro Ala Trp Ser Gln Val Ala Leu Gln Gly
        1155                1160                1165            
 Pro Ile Glu Arg Ala Gln Val His Val Cys Ser Ser Lys Met Gly Ala
    1170                1175                1180                
 Leu Ser Thr Glu Arg Leu Gln Tyr Tyr Thr Gln Glu Leu Gly Val Arg
1185                1190                1195                1200
 Glu Arg Ser Gly His Ser Val Ser Leu Ile Asp Leu Trp Gly Leu Leu
                1205                1210                1215    
 Val Glu Tyr Leu Leu Tyr Gln Glu Glu Asn Pro Ala Lys Leu Ser Asp
            1220                1225                1230        
 Gln Gln Lys Ala Val Arg Gln Gly Gln Asn Pro Tyr Pro Ile Tyr Thr
        1235                1240                1245            
 Ser Val Asn Val Arg Thr Asn Leu Ser Gly Glu Asp Phe Ala Lys Trp
    1250                1255                1260                
 Cys Glu Phe Thr Pro Tyr Lys Val Gly Phe Pro Lys Tyr Gly Ala Tyr
1265                1270                1275                1280
 Val Pro Thr Glu Leu Phe Gly Ser Glu Leu Phe Met Gly Arg Leu Leu
                1285                1290                1295    
 Gln Leu Gln Pro Glu Pro Arg Ile Cys Tyr Leu Gln Gly Met Trp Gly
            1300                1305                1310        
 Ser Ala Phe Ala Thr Ser Leu Asp Glu Ile Phe Leu Lys Thr Ala Gly
        1315                1320                1325            
 Ser Gly Leu Ser Phe Leu Glu Trp Tyr Arg Gly Ser Val Asn Ile Thr
    1330                1335                1340                
 Asp Asp Cys Gln Lys Pro Gln Leu His Asn Pro Ser Arg Leu Arg Thr
1345                1350                1355                1360
 Arg Leu Leu Thr Pro Gln Gly Pro Phe Ser Gln Ala Val Leu Asp Ile
                1365                1370                1375    
 Phe Thr Ser Arg Phe Thr Ser Ala Gln Ser Phe Asn Phe Thr Arg Gly
            1380                1385                1390        
 Leu Cys Leu His Lys Asp Tyr Val Ala Gly Arg Glu Phe Val Ala Trp
        1395                1400                1405            
 Lys Asp Thr His Pro Asp Ala Phe Pro Asn Gln Leu Thr Pro Met Arg
    1410                1415                1420                
 Asp Cys Leu Tyr Leu Val Asp Gly Gly Phe Ala Ile Asn Ser Pro Phe
1425                1430                1435                1440
 Pro Leu Ala Leu Leu Pro Gln Arg Ala Val Asp Leu Ile Leu Ser Phe
                1445                1450                1455    
 Asp Tyr Ser Leu Glu Ala Pro Phe Glu Val Leu Lys Met Thr Glu Lys
            1460                1465                1470        
 Tyr Cys Leu Asp Arg Gly Ile Pro Phe Pro Ser Ile Glu Val Gly Pro
        1475                1480                1485            
 Glu Asp Val Glu Glu Ala Arg Glu Cys Tyr Leu Phe Ala Lys Ala Glu
    1490                1495                1500                
 Asp Pro Arg Ser Pro Ile Val Leu His Phe Pro Leu Val Asn Arg Thr
1505                1510                1515                1520
 Phe Arg Thr His Leu Ala Pro Gly Val Glu Arg Gln Thr Ala Glu Glu
                1525                1530                1535    
 Lys Ala Phe Gly Asp Phe Val Ile Asn Arg Pro Asp Thr Pro Tyr Gly
            1540                1545                1550        
 Met Met Asn Phe Thr Tyr Glu Pro Gln Asp Phe Tyr Arg Leu Val Ala
        1555                1560                1565            
 Leu Ser Arg Tyr Asn Val Leu Asn Asn Val Glu Thr Leu Lys Cys Ala
    1570                1575                1580                
 Leu Gln Leu Ala Leu Asp Arg His Gln Ala Arg Glu Arg Ala Gly Ala
1585                1590                1595                1600





      <210> 848
      <211> 849
      <212> PRT
      <213> Homo sapiens


      <400> 848
 Met Leu Trp Ala Leu Trp Pro Arg Trp Leu Ala Asp Lys Met Leu Pro
   1               5                  10                  15    
 Leu Leu Gly Ala Val Leu Leu Gln Lys Arg Glu Lys Arg Gly Pro Leu
              20                  25                  30        
 Trp Arg His Trp Arg Arg Glu Thr Tyr Pro Tyr Tyr Asp Leu Gln Val
          35                  40                  45            
 Lys Val Leu Arg Ala Thr Asn Ile Arg Gly Thr Asp Leu Leu Ser Lys
      50                  55                  60                
 Ala Asp Cys Tyr Val Gln Leu Trp Leu Pro Thr Ala Ser Pro Ser Pro
  65                  70                  75                  80
 Ala Gln Thr Arg Ile Val Ala Asn Cys Ser Asp Pro Glu Trp Asn Glu
                  85                  90                  95    
 Thr Phe His Tyr Gln Ile His Gly Ala Val Lys Asn Val Leu Glu Leu
             100                 105                 110        
 Thr Leu Tyr Asp Lys Asp Ile Leu Gly Ser Asp Gln Leu Ser Leu Leu
         115                 120                 125            
 Leu Phe Asp Leu Arg Ser Leu Lys Cys Gly Gln Pro His Lys His Thr
     130                 135                 140                
 Phe Pro Leu Asn His Gln Asp Ser Gln Glu Leu Gln Val Glu Phe Val
 145                 150                 155                 160
 Leu Glu Lys Ser Gln Val Pro Ala Ser Glu Val Ile Thr Asn Gly Val
                 165                 170                 175    
 Leu Val Ala His Pro Cys Leu Arg Ile Gln Gly Thr Leu Arg Gly Asp
             180                 185                 190        
 Gly Thr Ala Pro Arg Glu Glu Tyr Gly Ser Arg Gln Leu Gln Leu Ala
         195                 200                 205            
 Val Pro Gly Ala Tyr Glu Lys Pro Gln Leu Leu Pro Leu Gln Pro Pro
     210                 215                 220                
 Thr Glu Pro Gly Leu Pro Pro Ser Phe Thr Phe His Val Asn Pro Val
 225                 230                 235                 240
 Leu Ser Ser Arg Leu His Val Glu Leu Met Glu Leu Leu Ala Ala Val
                 245                 250                 255    
 Gln Ser Gly Pro Ser Ala Glu Leu Glu Ala Gln Thr Ser Lys Leu Gly
             260                 265                 270        
 Glu Gly Gly Ile Leu Leu Ser Ser Leu Pro Leu Gly Gln Glu Glu Gln
         275                 280                 285            
 Cys Ser Val Ala Leu Gly Glu Gly Gln Glu Val Ala Leu Ser Met Lys
     290                 295                 300                
 Val Glu Met Ser Ser Gly Asp Leu Asp Leu Arg Leu Gly Phe Asp Leu
 305                 310                 315                 320
 Ser Asp Gly Glu Gln Glu Phe Leu Asp Arg Arg Lys Gln Val Val Ser
                 325                 330                 335    
 Lys Ala Leu Gln Gln Val Leu Gly Leu Ser Glu Ala Leu Asp Ser Thr
             340                 345                 350        
 Gln Val Pro Val Val Ala Val Leu Gly Ser Gly Gly Gly Thr Arg Ala
         355                 360                 365            
 Met Ser Ser Leu Tyr Gly Ser Leu Ala Gly Leu Gln Glu Leu Gly Leu
     370                 375                 380                
 Leu Asp Thr Val Thr Tyr Leu Ser Gly Val Ser Gly Ser Thr Trp Cys
 385                 390                 395                 400
 Ile Ser Thr Leu Tyr Arg Asp Pro Ala Trp Ser Gln Val Ala Leu Gln
                 405                 410                 415    
 Gly Pro Ile Glu Arg Ala Gln Val His Val Cys Ser Ser Lys Met Gly
             420                 425                 430        
 Ala Leu Ser Thr Glu Arg Leu Gln Tyr Tyr Thr Gln Glu Leu Gly Val
         435                 440                 445            
 Arg Glu Arg Ser Gly His Ser Val Ser Leu Ile Asp Leu Trp Gly Leu
     450                 455                 460                
 Leu Val Glu Tyr Leu Leu Tyr Gln Glu Glu Asn Pro Ala Lys Leu Ser
 465                 470                 475                 480
 Asp Gln Gln Glu Ala Val Arg Gln Gly Gln Asn Pro Tyr Pro Ile Tyr
                 485                 490                 495    
 Thr Ser Val Asn Val Arg Thr Asn Leu Ser Gly Glu Asp Phe Ala Glu
             500                 505                 510        
 Trp Cys Glu Phe Thr Pro Tyr Glu Val Gly Phe Pro Lys Tyr Gly Ala
         515                 520                 525            
 Tyr Val Pro Thr Glu Leu Phe Gly Ser Glu Leu Phe Met Gly Arg Leu
     530                 535                 540                
 Leu Gln Leu Gln Pro Glu Pro Arg Ile Cys Tyr Leu Gln Gly Met Trp
 545                 550                 555                 560
 Gly Ser Ala Phe Ala Thr Ser Leu Asp Glu Ile Phe Leu Lys Thr Ala
                 565                 570                 575    
 Gly Ser Gly Leu Ser Phe Leu Glu Trp Tyr Arg Gly Ser Val Asn Ile
             580                 585                 590        
 Thr Asp Asp Cys Gln Lys Pro Gln Leu His Asn Pro Ser Arg Leu Arg
         595                 600                 605            
 Thr Arg Leu Leu Thr Pro Gln Gly Pro Phe Ser Gln Ala Val Leu Asp
     610                 615                 620                
 Ile Phe Thr Ser Arg Phe Thr Ser Ala Gln Ser Phe Asn Phe Thr Arg
 625                 630                 635                 640
 Gly Leu Cys Leu His Lys Asp Tyr Val Ala Gly Arg Glu Phe Val Ala
                 645                 650                 655    
 Trp Lys Asp Thr His Pro Asp Ala Phe Pro Asn Gln Leu Thr Pro Met
             660                 665                 670        
 Arg Asp Cys Leu Tyr Leu Val Asp Gly Gly Phe Ala Ile Asn Ser Pro
         675                 680                 685            
 Phe Pro Leu Ala Leu Leu Pro Gln Arg Ala Val Asp Leu Ile Leu Ser
     690                 695                 700                
 Phe Asp Tyr Ser Leu Glu Ala Pro Phe Glu Val Leu Lys Met Thr Glu
 705                 710                 715                 720
 Lys Tyr Cys Leu Asp Arg Gly Ile Pro Phe Pro Ser Ile Glu Val Gly
                 725                 730                 735    
 Pro Glu Asp Val Glu Glu Ala Arg Glu Cys Tyr Leu Phe Ala Lys Ala
             740                 745                 750        
 Glu Asp Pro Arg Ser Pro Ile Val Leu His Phe Pro Leu Val Asn Arg
         755                 760                 765            
 Thr Phe Arg Thr His Leu Ala Pro Gly Val Glu Arg Gln Thr Ala Glu
     770                 775                 780                
 Glu Lys Ala Phe Gly Asp Phe Val Ile Asn Arg Pro Asp Thr Pro Tyr
 785                 790                 795                 800
 Gly Met Met Asn Phe Thr Tyr Glu Pro Gln Asp Phe Tyr Arg Leu Val
                 805                 810                 815    
 Ala Leu Ser Arg Tyr Asn Val Leu Asn Asn Val Glu Thr Leu Lys Cys
             820                 825                 830        
 Ala Leu Gln Leu Ala Leu Asp Arg His Gln Ala Arg Glu Arg Ala Gly
         835                 840                 845            
 Ala
    



      <210> 849
      <211> 201
      <212> PRT
      <213> Homo sapiens


      <400> 849
 Met Gly Asn Leu Phe Gly Arg Lys Lys Gln Ser Arg Val Thr Glu Gln
   1               5                  10                  15    
 Asp Lys Ala Ile Leu Gln Leu Lys Gln Gln Arg Asp Lys Leu Arg Gln
              20                  25                  30        
 Tyr Gln Lys Arg Ile Ala Gln Gln Leu Glu Arg Glu Arg Ala Leu Ala
          35                  40                  45            
 Arg Gln Leu Leu Arg Asp Gly Arg Lys Glu Arg Ala Lys Leu Leu Leu
      50                  55                  60                
 Lys Lys Lys Arg Tyr Gln Glu Gln Leu Leu Asp Arg Thr Glu Asn Gln
  65                  70                  75                  80
 Ile Ser Ser Leu Glu Ala Met Val Gln Ser Ile Glu Phe Thr Gln Ile
                  85                  90                  95    
 Glu Met Lys Val Met Glu Gly Leu Gln Phe Gly Asn Glu Cys Leu Asn
             100                 105                 110        
 Lys Met His Gln Val Met Ser Ile Glu Glu Val Glu Arg Ile Leu Asp
         115                 120                 125            
 Glu Thr Gln Glu Ala Val Glu Tyr Gln Arg Gln Ile Asp Glu Leu Leu
     130                 135                 140                
 Ala Gly Ser Phe Thr Gln Glu Asp Glu Asp Ala Ile Leu Glu Glu Leu
 145                 150                 155                 160
 Ser Ala Ile Thr Gln Glu Gln Ile Glu Leu Pro Glu Val Pro Ser Glu
                 165                 170                 175    
 Pro Leu Pro Glu Lys Ile Pro Glu Asn Val Pro Val Lys Ala Arg Pro
             180                 185                 190        
 Arg Gln Ala Glu Leu Val Ala Ala Ser
         195                 200    



      <210> 850
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 850
 Met Tyr Phe Tyr Pro Ile Tyr Arg Met Ser Glu Met Ile Phe Arg Arg
   1               5                  10                  15    
 Ile Lys Met Pro Trp Leu Trp Leu Asp Leu Trp Tyr Leu Met Phe Lys
              20                  25                  30        
 Glu Gly Trp Glu His Lys Lys Ser Leu Gln Ile Leu His Thr Phe Thr
          35                  40                  45            
 Asn Ser Val Ile Ala Glu Arg Ala Asn Glu Met Asn Ala Asn Glu Asp
      50                  55                  60                
 Cys Arg Gly Asp Gly Arg Gly Ser Ala Pro Ser Lys Asn Lys Arg Arg
  65                  70                  75                  80
 Ala Phe Leu Asp Leu Leu Leu Ser Val Thr Asp Asp Glu Gly Asn Arg
                  85                  90                  95    
 Leu Ser His Glu Asp Ile Arg Glu Glu Val Asp Thr Phe Met Phe Glu
             100                 105                 110        
 Val Leu Tyr Ile Val Arg Phe Arg Tyr His
         115                 120        



      <210> 851
      <211> 506
      <212> PRT
      <213> Homo sapiens


      <400> 851
 Met Trp Ala Ala Glu Ala Trp Val Arg Gly Thr Ala Pro Arg Pro Leu
   1               5                  10                  15    
 Cys Ser Ser Trp Ala Gly Asp Pro Gly Gly Ala Gln Ala Arg Gly Pro
              20                  25                  30        
 Pro Lys Met Ala Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly
          35                  40                  45            
 Arg Thr Val Arg Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu
      50                  55                  60                
 Thr Met Trp Thr Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg
  65                  70                  75                  80
 Phe Arg Val Leu Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu
                  85                  90                  95    
 Asp Ala Gly Val Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser Leu
             100                 105                 110        
 Ser Val Asn Tyr Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys
         115                 120                 125            
 Glu Ser Leu Gly Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala
     130                 135                 140                
 Ser Gln Gln Trp Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg
 145                 150                 155                 160
 Arg Arg Val Ile Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys
                 165                 170                 175    
 Val Ala Ser Gly His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp
             180                 185                 190        
 Gln Ala Leu Thr Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp
         195                 200                 205            
 Thr Leu Ser Leu Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr
     210                 215                 220                
 Cys Arg Val Ser Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val
 225                 230                 235                 240
 Asp Val Ile Gln Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His
                 245                 250                 255    
 Pro Val Asn Thr Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys
             260                 265                 270        
 Lys Val Arg Ser Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val
         275                 280                 285            
 Glu Tyr Gly Ala Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly
     290                 295                 300                
 Gln Lys Phe Val Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp
 305                 310                 315                 320
 Gly Ser Tyr Leu Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp
                 325                 330                 335    
 Ala Gly Met Tyr Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe
             340                 345                 350        
 Arg Ser Ala Phe Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro
         355                 360                 365            
 Pro Val Ala Ser Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val
     370                 375                 380                
 Ile Gly Ile Pro Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu
 385                 390                 395                 400
 Trp Leu Cys Gln Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro
                 405                 410                 415    
 Pro Leu Pro Gly His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly
             420                 425                 430        
 Asp Lys Asp Leu Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val
         435                 440                 445            
 Gly Leu Cys Glu Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu
     450                 455                 460                
 Gly Pro Gly Pro Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr
 465                 470                 475                 480
 Asp Ile His Thr His Thr Tyr Thr His Pro His Leu Leu Gln Leu Asn
                 485                 490                 495    
 Ser Ser Ile Thr Lys Asn Lys Lys Lys Lys
             500                 505    



      <210> 852
      <211> 504
      <212> PRT
      <213> Homo sapiens


      <400> 852
 Met Thr Pro Ser Pro Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu
   1               5                  10                  15    
 Gly Ala Phe Pro Pro Ala Ala Ala Ala Arg Gly Pro Pro Lys Met Ala
              20                  25                  30        
 Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr Val Arg
          35                  40                  45            
 Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met Trp Thr
      50                  55                  60                
 Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg Val Leu
  65                  70                  75                  80
 Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala Gly Val
                  85                  90                  95    
 Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser Leu Ser Val Asn Tyr
             100                 105                 110        
 Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys Glu Ser Leu Gly
         115                 120                 125            
 Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln Trp
     130                 135                 140                
 Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val Ile
 145                 150                 155                 160
 Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser Gly
                 165                 170                 175    
 His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu Thr
             180                 185                 190        
 Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser Leu
         195                 200                 205            
 Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val Ser
     210                 215                 220                
 Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile Gln
 225                 230                 235                 240
 Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn Thr
                 245                 250                 255    
 Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg Ser
             260                 265                 270        
 Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly Ala
         275                 280                 285            
 Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe Val
     290                 295                 300                
 Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr Leu
 305                 310                 315                 320
 Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met Tyr
                 325                 330                 335    
 Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala Phe
             340                 345                 350        
 Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val Ala Ser
         355                 360                 365            
 Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile Pro
     370                 375                 380                
 Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys Gln
 385                 390                 395                 400
 Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro Gly
                 405                 410                 415    
 His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp Leu
             420                 425                 430        
 Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys Glu
         435                 440                 445            
 Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly Pro
     450                 455                 460                
 Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Asp Ile His Thr
 465                 470                 475                 480
 His Thr His Thr His Ser His Thr His Ser His Val Glu Gly Lys Val
                 485                 490                 495    
 His Gln His Ile His Tyr Gln Cys
             500                



      <210> 853
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 853
 Met Thr Pro Ser Pro Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu
   1               5                  10                  15    
 Gly Ala Phe Pro Pro Ala Ala Ala Ala Arg Gly Pro Pro Lys Met Ala
              20                  25                  30        
 Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr Val Arg
          35                  40                  45            
 Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met Trp Thr
      50                  55                  60                
 Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg Val Leu
  65                  70                  75                  80
 Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala Gly Val
                  85                  90                  95    
 Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser Leu Ser Val Lys Arg
             100                 105                 110        
 Thr Pro Pro Ala Ser Ser Gly His Asp Arg Ala Ser His Ser Pro Pro
         115                 120                 125            
 Arg
    



      <210> 854
      <211> 409
      <212> PRT
      <213> Homo sapiens


      <400> 854
 Met Arg Val Met His Leu Ala Pro Gly Pro Gly Ser Pro Ser Glu Leu
   1               5                  10                  15    
 Arg Ala Pro Ser Arg Asp Val Leu Leu Val Ser Ala Ile Ile Thr Val
              20                  25                  30        
 Ser Leu Ser Val Thr Val Val Leu Cys Gly Leu Cys His Trp Cys Gln
          35                  40                  45            
 Arg Lys Leu Gly Lys Arg Tyr Lys Asn Ser Leu Glu Thr Val Gly Thr
      50                  55                  60                
 Pro Asp Ser Gly Arg Gly Arg Ser Glu Lys Lys Ala Ile Lys Leu Pro
  65                  70                  75                  80
 Ala Gly Gly Lys Ala Val Asn Thr Ala Pro Val Pro Gly Gln Thr Pro
                  85                  90                  95    
 His Asp Glu Ser Asp Arg Arg Thr Glu Pro Arg Ser Ser Val Ser Asp
             100                 105                 110        
 Leu Val Asn Ser Leu Thr Ser Glu Met Leu Met Leu Ser Pro Gly Ser
         115                 120                 125            
 Glu Glu Asp Glu Ala His Glu Gly Cys Ser Arg Glu Asn Leu Gly Arg
     130                 135                 140                
 Ile Gln Phe Ser Val Gly Tyr Asn Phe Gln Glu Ser Thr Leu Thr Leu
 145                 150                 155                 160
 Lys Ile Met Lys Ala Gln Glu Leu Pro Ala Lys Asp Phe Ser Gly Thr
                 165                 170                 175    
 Ser Asp Pro Phe Val Lys Ile Tyr Leu Leu Pro Asp Lys Lys His Lys
             180                 185                 190        
 Leu Lys Thr Lys Val Lys Arg Lys Asn Leu Asn Pro His Trp Asn Glu
         195                 200                 205            
 Thr Phe Leu Phe Glu Gly Phe Pro Tyr Glu Lys Val Val Gln Arg Ile
     210                 215                 220                
 Leu Tyr Leu Gln Val Leu Asp Tyr Asp Arg Phe Ser Arg Asn Asp Pro
 225                 230                 235                 240
 Ile Gly Glu Val Ser Ile Pro Leu Asn Lys Val Asp Leu Thr Gln Met
                 245                 250                 255    
 Gln Thr Phe Trp Lys Asp Leu Lys Pro Cys Ser Asp Gly Ser Gly Ser
             260                 265                 270        
 Arg Gly Glu Leu Leu Leu Ser Leu Cys Tyr Asn Pro Ser Ala Asn Ser
         275                 280                 285            
 Ile Ile Val Asn Ile Ile Lys Ala Arg Asn Leu Lys Ala Met Asp Ile
     290                 295                 300                
 Gly Gly Thr Ser Asp Pro Tyr Val Lys Val Trp Leu Met Tyr Lys Asp
 305                 310                 315                 320
 Lys Arg Val Glu Lys Lys Lys Thr Val Thr Met Lys Arg Asn Leu Asn
                 325                 330                 335    
 Pro Ile Phe Asn Glu Ser Phe Ala Phe Asp Ile Pro Thr Glu Lys Leu
             340                 345                 350        
 Arg Glu Thr Thr Ile Ile Ile Thr Val Met Asp Lys Asp Lys Leu Ser
         355                 360                 365            
 Arg Asn Asp Val Ile Gly Lys Ile Tyr Leu Ser Trp Lys Ser Gly Pro
     370                 375                 380                
 Gly Glu Val Lys His Trp Lys Asp Met Ile Ala Arg Pro Arg Gln Pro
 385                 390                 395                 400
 Val Ala Gln Trp His Gln Leu Lys Ala
                 405                



      <210> 855
      <211> 1593
      <212> PRT
      <213> Homo sapiens


      <400> 855
 Met Pro Cys Ala Gln Arg Ser Trp Leu Ala Asn Leu Ser Val Val Ala
   1               5                  10                  15    
 Gln Leu Leu Asn Phe Gly Ala Leu Cys Tyr Gly Arg Gln Pro Gln Pro
              20                  25                  30        
 Gly Pro Val Arg Phe Pro Asp Arg Arg Gln Glu His Phe Ile Lys Gly
          35                  40                  45            
 Leu Pro Glu Tyr His Val Val Gly Pro Val Arg Val Asp Ala Ser Gly
      50                  55                  60                
 His Phe Leu Ser Tyr Gly Leu His Tyr Pro Ile Thr Ser Ser Arg Arg
  65                  70                  75                  80
 Lys Arg Asp Leu Asp Gly Ser Glu Asp Trp Val Tyr Tyr Arg Ile Ser
                  85                  90                  95    
 His Glu Glu Lys Asp Leu Phe Phe Asn Leu Thr Val Asn Gln Gly Phe
             100                 105                 110        
 Leu Ser Asn Ser Tyr Ile Met Glu Lys Arg Tyr Gly Asn Leu Ser His
         115                 120                 125            
 Val Lys Met Met Ala Ser Ser Ala Pro Leu Cys His Leu Ser Gly Thr
     130                 135                 140                
 Val Leu Gln Gln Gly Thr Arg Val Gly Thr Ala Ala Leu Ser Ala Cys
 145                 150                 155                 160
 His Gly Leu Thr Gly Phe Phe Gln Leu Pro His Gly Asp Phe Phe Ile
                 165                 170                 175    
 Glu Pro Val Lys Lys His Pro Leu Val Glu Gly Gly Tyr His Pro His
             180                 185                 190        
 Ile Val Tyr Arg Arg Gln Lys Val Pro Glu Thr Lys Glu Pro Thr Cys
         195                 200                 205            
 Gly Leu Lys Asp Ser Val Asn Ile Ser Gln Lys Gln Glu Leu Trp Arg
     210                 215                 220                
 Glu Lys Trp Glu Arg His Asn Leu Pro Ser Arg Ser Leu Ser Arg Arg
 225                 230                 235                 240
 Ser Ile Ser Lys Glu Arg Trp Val Glu Thr Leu Val Val Ala Asp Thr
                 245                 250                 255    
 Lys Met Ile Glu Tyr His Gly Ser Glu Asn Val Glu Ser Tyr Ile Leu
             260                 265                 270        
 Thr Ile Met Asn Met Val Thr Gly Leu Phe His Asn Pro Ser Ile Gly
         275                 280                 285            
 Asn Ala Ile His Ile Val Val Val Arg Leu Ile Leu Leu Glu Glu Glu
     290                 295                 300                
 Glu Gln Gly Leu Lys Ile Val His His Ala Glu Lys Thr Leu Ser Ser
 305                 310                 315                 320
 Phe Cys Lys Trp Gln Lys Ser Ile Asn Pro Lys Ser Asp Leu Asn Pro
                 325                 330                 335    
 Val His His Asp Val Ala Val Leu Leu Thr Arg Lys Asp Ile Cys Ala
             340                 345                 350        
 Gly Phe Asn Arg Pro Cys Glu Thr Leu Gly Leu Ser His Leu Ser Gly
         355                 360                 365            
 Met Cys Gln Pro His Arg Ser Cys Asn Ile Asn Glu Asp Ser Gly Leu
     370                 375                 380                
 Pro Leu Ala Phe Thr Ile Ala His Glu Leu Gly His Ser Phe Gly Ile
 385                 390                 395                 400
 Gln His Asp Gly Lys Glu Asn Asp Cys Glu Pro Val Gly Arg His Pro
                 405                 410                 415    
 Tyr Ile Met Ser Arg Gln Leu Gln Tyr Asp Pro Thr Pro Leu Thr Trp
             420                 425                 430        
 Ser Lys Cys Ser Glu Glu Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp
         435                 440                 445            
 Gly Phe Cys Leu Asp Asp Ile Pro Lys Lys Lys Gly Leu Lys Ser Lys
     450                 455                 460                
 Val Ile Ala Pro Gly Val Ile Tyr Asp Val His His Gln Cys Gln Leu
 465                 470                 475                 480
 Gln Tyr Gly Pro Asn Ala Thr Phe Cys Gln Glu Val Glu Asn Val Cys
                 485                 490                 495    
 Gln Thr Leu Trp Cys Ser Val Lys Gly Phe Cys Arg Ser Lys Leu Asp
             500                 505                 510        
 Ala Ala Ala Asp Gly Thr Gln Cys Gly Glu Lys Lys Trp Cys Met Ala
         515                 520                 525            
 Gly Lys Cys Ile Thr Val Gly Lys Lys Pro Glu Ser Ile Pro Gly Gly
     530                 535                 540                
 Trp Gly Arg Trp Ser Pro Trp Ser His Cys Ser Arg Thr Cys Gly Ala
 545                 550                 555                 560
 Gly Val Gln Ser Ala Glu Arg Leu Cys Asn Asn Pro Glu Pro Lys Phe
                 565                 570                 575    
 Gly Gly Lys Tyr Cys Thr Gly Glu Arg Lys Arg Tyr Arg Leu Cys Asn
             580                 585                 590        
 Val His Pro Cys Arg Ser Glu Ala Pro Thr Phe Arg Gln Met Gln Cys
         595                 600                 605            
 Ser Glu Phe Asp Thr Val Pro Tyr Lys Asn Glu Leu Tyr His Trp Phe
     610                 615                 620                
 Pro Ile Phe Asn Pro Ala His Pro Cys Glu Leu Tyr Cys Arg Pro Ile
 625                 630                 635                 640
 Asp Gly Gln Phe Ser Glu Lys Met Leu Asp Ala Val Ile Asp Gly Thr
                 645                 650                 655    
 Pro Cys Phe Glu Gly Gly Asn Ser Arg Asn Val Cys Ile Asn Gly Ile
             660                 665                 670        
 Cys Lys Met Val Gly Cys Asp Tyr Glu Ile Asp Ser Asn Ala Thr Glu
         675                 680                 685            
 Asp Arg Cys Gly Val Cys Leu Gly Asp Gly Ser Ser Cys Gln Thr Val
     690                 695                 700                
 Arg Lys Met Phe Lys Gln Lys Glu Gly Ser Gly Tyr Val Asp Ile Gly
 705                 710                 715                 720
 Leu Ile Pro Lys Gly Ala Arg Asp Ile Arg Val Met Glu Ile Glu Gly
                 725                 730                 735    
 Ala Gly Asn Phe Leu Ala Ile Arg Ser Glu Asp Pro Glu Lys Tyr Tyr
             740                 745                 750        
 Leu Asn Gly Gly Phe Ile Ile Gln Trp Asn Gly Asn Tyr Lys Leu Ala
         755                 760                 765            
 Gly Thr Val Phe Gln Tyr Asp Arg Lys Gly Asp Leu Glu Lys Leu Met
     770                 775                 780                
 Ala Thr Gly Pro Thr Asn Glu Ser Val Trp Ile Gln Leu Leu Phe Gln
 785                 790                 795                 800
 Val Thr Asn Pro Gly Ile Lys Tyr Glu Tyr Thr Ile Gln Lys Asp Gly
                 805                 810                 815    
 Leu Asp Asn Asp Val Glu Gln Met Tyr Phe Trp Gln Tyr Gly His Trp
             820                 825                 830        
 Thr Glu Cys Ser Val Thr Cys Gly Thr Gly Ile Arg Arg Gln Thr Ala
         835                 840                 845            
 His Cys Ile Lys Lys Gly Arg Gly Met Val Lys Ala Thr Phe Cys Asp
     850                 855                 860                
 Pro Glu Thr Gln Pro Asn Gly Arg Gln Lys Lys Cys His Glu Lys Ala
 865                 870                 875                 880
 Cys Pro Pro Arg Trp Trp Ala Gly Glu Trp Glu Ala Cys Ser Ala Thr
                 885                 890                 895    
 Cys Gly Pro His Gly Glu Lys Lys Arg Thr Val Leu Cys Ile Gln Thr
             900                 905                 910        
 Met Val Ser Asp Glu Gln Ala Leu Pro Pro Thr Asp Cys Gln His Leu
         915                 920                 925            
 Leu Lys Pro Lys Thr Leu Leu Ser Cys Asn Arg Asp Ile Leu Cys Pro
     930                 935                 940                
 Ser Asp Trp Thr Val Gly Asn Trp Ser Glu Cys Ser Val Ser Cys Gly
 945                 950                 955                 960
 Gly Gly Val Arg Ile Arg Ser Val Thr Cys Ala Lys Asn His Asp Glu
                 965                 970                 975    
 Pro Cys Asp Val Thr Arg Lys Pro Asn Ser Arg Ala Leu Cys Gly Leu
             980                 985                 990        
 Gln Gln Cys Pro Ser Ser Arg Arg Val Leu Lys Pro Asn Lys Gly Thr
         995                1000                1005            
 Ile Ser Asn Gly Lys Asn Pro Pro Thr Leu Lys Pro Val Pro Pro Pro
    1010                1015                1020                
 Thr Ser Arg Pro Arg Met Leu Thr Thr Pro Thr Gly Pro Glu Ser Met
1025                1030                1035                1040
 Ser Thr Ser Thr Pro Ala Ile Ser Ser Pro Ser Pro Thr Thr Ala Ser
                1045                1050                1055    
 Lys Glu Gly Asp Leu Gly Gly Lys Gln Trp Gln Asp Ser Ser Thr Gln
            1060                1065                1070        
 Pro Glu Leu Ser Ser Arg Tyr Leu Ile Ser Thr Gly Ser Thr Ser Gln
        1075                1080                1085            
 Pro Ile Leu Thr Ser Gln Ser Leu Ser Ile Gln Pro Ser Glu Glu Asn
    1090                1095                1100                
 Val Ser Ser Ser Asp Thr Gly Pro Thr Ser Glu Gly Gly Leu Val Ala
1105                1110                1115                1120
 Thr Thr Thr Ser Gly Ser Gly Leu Ser Ser Ser Arg Asn Pro Ile Thr
                1125                1130                1135    
 Trp Pro Val Thr Pro Phe Tyr Asn Thr Leu Thr Lys Gly Pro Glu Met
            1140                1145                1150        
 Glu Ile His Ser Gly Ser Gly Glu Glu Arg Glu Gln Pro Glu Asp Lys
        1155                1160                1165            
 Asp Glu Ser Asn Pro Val Ile Trp Thr Lys Ile Arg Val Pro Gly Asn
    1170                1175                1180                
 Asp Ala Pro Val Glu Ser Thr Glu Met Pro Leu Ala Pro Pro Leu Thr
1185                1190                1195                1200
 Pro Asp Leu Ser Arg Glu Ser Trp Trp Pro Pro Phe Ser Thr Val Met
                1205                1210                1215    
 Glu Gly Leu Leu Pro Ser Gln Arg Pro Thr Thr Ser Glu Thr Gly Thr
            1220                1225                1230        
 Pro Arg Val Glu Gly Met Val Thr Glu Lys Pro Ala Asn Thr Leu Leu
        1235                1240                1245            
 Pro Leu Gly Gly Asp His Gln Pro Glu Pro Ser Gly Lys Thr Ala Asn
    1250                1255                1260                
 Arg Asn His Leu Lys Leu Pro Asn Asn Met Asn Gln Thr Lys Ser Ser
1265                1270                1275                1280
 Glu Pro Val Leu Thr Glu Glu Asp Ala Thr Ser Leu Ile Thr Glu Gly
                1285                1290                1295    
 Phe Leu Leu Asn Ala Ser Asn Tyr Lys Gln Leu Thr Asn Gly His Gly
            1300                1305                1310        
 Ser Ala His Trp Ile Val Gly Asn Trp Ser Glu Cys Ser Thr Thr Cys
        1315                1320                1325            
 Gly Leu Gly Ala Tyr Trp Lys Arg Val Glu Cys Thr Thr Gln Met Asp
    1330                1335                1340                
 Ser Asp Cys Ala Ala Ile Gln Arg Pro Asp Pro Ala Lys Arg Cys His
1345                1350                1355                1360
 Leu Arg Pro Cys Ala Gly Trp Lys Val Gly Asn Trp Ser Lys Cys Ser
                1365                1370                1375    
 Arg Asn Cys Ser Gly Gly Phe Lys Ile Arg Glu Ile Gln Cys Val Asp
            1380                1385                1390        
 Ser Arg Asp His Arg Asn Leu Arg Pro Phe His Cys Gln Phe Leu Ala
        1395                1400                1405            
 Gly Ile Pro Pro Pro Leu Ser Met Ser Cys Asn Pro Glu Pro Cys Glu
    1410                1415                1420                
 Ala Trp Gln Val Glu Pro Trp Ser Gln Cys Ser Arg Ser Cys Gly Gly
1425                1430                1435                1440
 Gly Val Gln Glu Arg Gly Val Phe Cys Pro Gly Gly Leu Cys Asp Trp
                1445                1450                1455    
 Thr Lys Arg Pro Thr Ser Thr Met Ser Cys Asn Glu His Leu Cys Cys
            1460                1465                1470        
 His Trp Ala Thr Gly Asn Trp Asp Leu Cys Ser Thr Ser Cys Gly Gly
        1475                1480                1485            
 Gly Phe Gln Lys Arg Ile Val Gln Cys Val Pro Ser Glu Gly Asn Lys
    1490                1495                1500                
 Thr Glu Asp Gln Asp Gln Cys Leu Cys Asp His Lys Pro Arg Pro Pro
1505                1510                1515                1520
 Glu Phe Lys Lys Cys Asn Gln Gln Ala Cys Lys Lys Ser Ala Asp Leu
                1525                1530                1535    
 Leu Cys Thr Lys Asp Lys Leu Ser Ala Ser Phe Cys Gln Thr Leu Lys
            1540                1545                1550        
 Ala Met Lys Lys Cys Ser Val Pro Thr Val Arg Ala Glu Cys Cys Phe
        1555                1560                1565            
 Ser Cys Pro Gln Thr His Ile Thr His Thr Gln Arg Gln Arg Arg Gln
    1570                1575                1580                
 Arg Leu Leu Gln Lys Ser Lys Glu Leu
1585                1590            



      <210> 856
      <211> 50
      <212> PRT
      <213> Homo sapiens


      <400> 856
 Met Gly Lys Glu Ser Gly Trp Asp Ser Gly Arg Ala Ala Val Ala Ala
   1               5                  10                  15    
 Val Val Gly Gly Gly Ala Ala Gly Leu Ser Val Thr Ser Lys Val Ile
              20                  25                  30        
 Gly Gly Phe Ala Gly Thr Ala Leu Gly Ala Trp Leu Gly Ser Pro Pro
          35                  40                  45            
 Ser Ser
      50



      <210> 857
      <211> 329
      <212> PRT
      <213> Homo sapiens


      <400> 857
 Met Pro Glu Pro Gly Pro Arg Met Asn Gly Phe Ser Leu Gly Glu Leu
   1               5                  10                  15    
 Cys Trp Leu Phe Cys Cys Pro Pro Cys Pro Ser Arg Ile Ala Ala Lys
              20                  25                  30        
 Leu Ala Phe Leu Pro Pro Glu Pro Thr Tyr Thr Val Leu Ala Pro Glu
          35                  40                  45            
 Gln Arg Ala Ala Gly Ala Ser Ala Pro Ala Pro Ala Gln Ala Thr Ala
      50                  55                  60                
 Ala Ala Ala Ala Ala Gln Pro Ala Pro Gln Gln Pro Glu Glu Gly Ala
  65                  70                  75                  80
 Gly Ala Gly Pro Gly Ala Cys Ser Leu His Leu Ser Glu Arg Ala Asp
                  85                  90                  95    
 Trp Gln Tyr Ser Gln Arg Glu Leu Asp Ala Val Glu Val Phe Phe Ser
             100                 105                 110        
 Arg Thr Ala Arg Asp Asn Arg Leu Gly Cys Met Phe Val Arg Cys Ala
         115                 120                 125            
 Pro Ser Ser Arg Tyr Thr Leu Leu Phe Ser His Gly Asn Ala Gly Asp
     130                 135                 140                
 Leu Gly Gln Met Cys Ser Phe Tyr Ile Gly Leu Gly Ser Arg Ile Asn
 145                 150                 155                 160
 Cys Asn Ile Phe Ser Tyr Asp Tyr Ser Gly Tyr Gly Val Ser Ser Gly
                 165                 170                 175    
 Lys Pro Ser Glu Lys Asn Leu Tyr Ala Asp Ile Asp Ala Ala Trp Gln
             180                 185                 190        
 Ala Leu Arg Thr Arg Tyr Gly Val Ser Pro Glu Asn Ile Ile Leu Tyr
         195                 200                 205            
 Gly Gln Ser Ile Gly Thr Val Pro Thr Val Asp Leu Ala Ser Arg Tyr
     210                 215                 220                
 Glu Cys Ala Ala Val Ile Leu His Ser Pro Leu Met Ser Gly Leu Arg
 225                 230                 235                 240
 Val Ala Phe Pro Asp Thr Arg Lys Thr Tyr Cys Phe Asp Ala Phe Pro
                 245                 250                 255    
 Ser Ile Asp Lys Ile Ser Lys Val Thr Ser Pro Val Leu Val Ile His
             260                 265                 270        
 Gly Thr Glu Asp Glu Val Ile Asp Phe Ser His Gly Leu Ala Met Tyr
         275                 280                 285            
 Glu Arg Cys Pro Arg Ala Val Glu Pro Leu Trp Val Glu Gly Ala Gly
     290                 295                 300                
 His Asn Asp Ile Glu Leu Tyr Ala Gln Tyr Leu Glu Arg Leu Lys Gln
 305                 310                 315                 320
 Phe Ile Ser His Glu Leu Pro Asn Ser
                 325                



      <210> 858
      <211> 322
      <212> PRT
      <213> Homo sapiens


      <400> 858
 Met Asn Gly Phe Ser Leu Gly Glu Leu Cys Trp Leu Phe Cys Cys Pro
   1               5                  10                  15    
 Pro Cys Pro Ser Arg Ile Ala Ala Lys Leu Ala Phe Leu Pro Pro Glu
              20                  25                  30        
 Pro Thr Tyr Thr Val Leu Ala Pro Glu Gln Arg Gly Ala Gly Ala Ser
          35                  40                  45            
 Ala Pro Ala Pro Ala Gln Ala Thr Ala Ala Ala Ala Ala Ala Gln Pro
      50                  55                  60                
 Ala Pro Gln Gln Pro Glu Glu Gly Ala Gly Ala Gly Pro Gly Ala Cys
  65                  70                  75                  80
 Ser Leu His Leu Ser Glu Arg Ala Asp Trp Gln Tyr Ser Gln Arg Glu
                  85                  90                  95    
 Leu Asp Ala Val Glu Val Phe Phe Ser Arg Thr Ala Arg Asp Asn Arg
             100                 105                 110        
 Leu Gly Cys Met Phe Val Arg Cys Ala Pro Ser Ser Arg Tyr Thr Leu
         115                 120                 125            
 Leu Phe Ser His Gly Asn Ala Gly Asp Leu Gly Gln Met Cys Ser Phe
     130                 135                 140                
 Tyr Ile Gly Leu Gly Ser Arg Ile Asn Cys Asn Ile Phe Ser Tyr Asp
 145                 150                 155                 160
 Tyr Ser Gly Tyr Gly Val Ser Ser Gly Lys Pro Ser Glu Lys Asn Leu
                 165                 170                 175    
 Tyr Ala Asp Ile Asp Ala Ala Trp Gln Ala Leu Arg Thr Arg Tyr Gly
             180                 185                 190        
 Val Ser Pro Glu Asn Ile Ile Leu Tyr Gly Gln Ser Ile Gly Thr Val
         195                 200                 205            
 Pro Thr Val Asp Leu Ala Ser Arg Tyr Glu Cys Ala Ala Val Ile Leu
     210                 215                 220                
 His Ser Pro Leu Met Ser Gly Leu Arg Val Ala Phe Pro Asp Thr Arg
 225                 230                 235                 240
 Lys Thr Tyr Cys Phe Asp Ala Phe Pro Ser Ile Asp Lys Ile Ser Lys
                 245                 250                 255    
 Val Thr Ser Pro Val Leu Val Ile His Gly Thr Glu Asp Glu Val Ile
             260                 265                 270        
 Asp Phe Ser His Gly Leu Ala Met Tyr Glu Arg Cys Pro Arg Ala Val
         275                 280                 285            
 Glu Pro Leu Trp Val Glu Gly Ala Gly His Asn Asp Ile Glu Leu Tyr
     290                 295                 300                
 Ala Gln Tyr Leu Glu Arg Leu Lys Gln Phe Ile Ser His Glu Leu Pro
 305                 310                 315                 320
 Asn Ser
        



      <210> 859
      <211> 435
      <212> PRT
      <213> Homo sapiens


      <400> 859
 Met Thr Leu Val Ile Lys Phe Pro His Ser Asn Phe Gly Gly Leu Ile
   1               5                  10                  15    
 Gln Ile Ala Ala Val Ser Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys
              20                  25                  30        
 Ala Leu Thr Arg Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu
          35                  40                  45            
 Gln Leu Arg Leu Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln
      50                  55                  60                
 Val Trp Lys Val Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu
  65                  70                  75                  80
 Ala Leu Ala Gly Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu
                  85                  90                  95    
 Gln Ala Gln Ala Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg Asp
             100                 105                 110        
 Arg Thr Gly Gln Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu
         115                 120                 125            
 Gln Val Glu Ser Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala Gly
     130                 135                 140                
 Leu Leu Asp Gly Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu Leu
 145                 150                 155                 160
 Ala Asp Val Gly Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser Tyr
                 165                 170                 175    
 Asp Val Ala Leu His Cys Thr Arg Leu Gln Asp Leu Arg Val Leu Val
             180                 185                 190        
 Ser Asn Ala Ser Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val Gly
         195                 200                 205            
 Met Glu Leu Gln Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val Thr
     210                 215                 220                
 Glu Asp Leu Arg Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg Asn
 225                 230                 235                 240
 Ile Ser Leu Ala Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly His
                 245                 250                 255    
 Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg
             260                 265                 270        
 Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly
         275                 280                 285            
 Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe
     290                 295                 300                
 Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg
 305                 310                 315                 320
 Ala Gly Asp Ala Ser Gly Val Glu Ala Pro Met Met Ile Arg Leu Val
                 325                 330                 335    
 Asn Gly Ser Gly Pro His Glu Gly Arg Val Glu Val Tyr His Asp Arg
             340                 345                 350        
 Arg Trp Gly Thr Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp
         355                 360                 365            
 Val Val Cys Arg Met Leu Ala Ser Arg Ser Trp Arg Arg Cys Thr Ala
     370                 375                 380                
 Gln Arg Arg Ser Gly Pro Gly Thr His Arg Ile Trp Met Asp Asp Val
 385                 390                 395                 400
 Pro Cys Lys Ala Pro Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys
                 405                 410                 415    
 Trp Gly Val Thr Asn Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys
             420                 425                 430        
 Asn Arg His
         435



      <210> 860
      <211> 495
      <212> PRT
      <213> Homo sapiens


      <400> 860
 Met Glu Asn Lys Ala Met Tyr Leu His Thr Val Ser Asp Cys Asp Thr
   1               5                  10                  15    
 Ser Ser Ile Cys Glu Asp Ser Phe Asp Gly Arg Ser Leu Ser Lys Leu
              20                  25                  30        
 Asn Leu Cys Glu Asp Gly Pro Cys His Lys Arg Arg Ala Ser Ile Cys
          35                  40                  45            
 Cys Thr Gln Leu Gly Ser Leu Ser Ala Leu Lys His Ala Val Leu Gly
      50                  55                  60                
 Leu Tyr Leu Leu Val Phe Leu Ile Leu Val Gly Ile Phe Ile Leu Ala
  65                  70                  75                  80
 Val Ser Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr Arg
                  85                  90                  95    
 Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu Arg Leu
             100                 105                 110        
 Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys Val
         115                 120                 125            
 Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu Ala Gly
     130                 135                 140                
 Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Gln Ala Gln Ala
 145                 150                 155                 160
 Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg Asp Arg Thr Gly Gln
                 165                 170                 175    
 Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu Ser
             180                 185                 190        
 Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala Gly Leu Leu Asp Gly
         195                 200                 205            
 Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu Leu Ala Asp Val Gly
     210                 215                 220                
 Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala Leu
 225                 230                 235                 240
 His Cys Thr Arg Leu Gln Asp Leu Arg Val Leu Val Ser Asn Ala Ser
                 245                 250                 255    
 Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val Gly Met Glu Leu Gln
             260                 265                 270        
 Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val Thr Glu Asp Leu Arg
         275                 280                 285            
 Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Ser Leu Ala
     290                 295                 300                
 Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu
 305                 310                 315                 320
 Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly
                 325                 330                 335    
 Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys
             340                 345                 350        
 Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg
         355                 360                 365            
 Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala
     370                 375                 380                
 Ser Gly Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly
 385                 390                 395                 400
 Pro His Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr
                 405                 410                 415    
 Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg
             420                 425                 430        
 Met Leu Gly Phe Arg Gly Val Glu Glu Val Tyr Arg Thr Ala Arg Phe
         435                 440                 445            
 Gly Gln Gly Thr Gly Arg Ile Trp Met Asp Asp Val Ala Cys Lys Gly
     450                 455                 460                
 Thr Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys Trp Gly Val Thr
 465                 470                 475                 480
 Asn Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys Asn Arg His
                 485                 490                 495



      <210> 861
      <211> 87
      <212> PRT
      <213> Homo sapiens


      <400> 861
 Met Leu Glu Cys Ser Gly Thr Ile Leu Ala His Cys Asn Leu His Leu
   1               5                  10                  15    
 Pro Gly Ser Ser Asn Ala Pro Ala Ser Ala Ser Arg Val Ala Arg Ile
              20                  25                  30        
 Thr Gly Ala His His His Ala Arg Leu Ile Phe Val Phe Leu Val Glu
          35                  40                  45            
 Met Gly Phe His Gln Thr Ala Gly His Ala Gly Leu Glu Leu Leu Thr
      50                  55                  60                
 Ser Gly Asp Met Pro Ala Leu Ala Ser Gln Ser Ala Gly Ile Thr Gly
  65                  70                  75                  80
 Met Ser His Ser Thr Trp Pro
                  85        



      <210> 862
      <211> 605
      <212> PRT
      <213> Homo sapiens


      <400> 862
 Met Tyr Ala Leu Tyr Arg Lys Lys His Asn Gly Tyr Arg Val Lys Tyr
   1               5                  10                  15    
 Asp Ser Glu Phe Gln Ala Ser Met Val Trp Gly Val Ser Trp Asn Ile
              20                  25                  30        
 Ser Pro Ile Asp Glu Gly Leu Leu Tyr Ile Tyr Lys Arg His Lys Glu
          35                  40                  45            
 Phe Thr Thr Glu Val Asp Lys Gly Cys Glu Thr Asn Ile Gln Met Lys
      50                  55                  60                
 Asp Asp Lys Ile Lys Lys Val Asp Asn His Leu Gln Met His Ser Gln
  65                  70                  75                  80
 Lys Gln Arg Cys Leu Lys Arg Val Glu Gln Cys His Lys His Asn Ala
                  85                  90                  95    
 Phe Gly Asn Ile Ile His Gln Arg Lys Ser Asp Phe Pro Leu Arg Gln
             100                 105                 110        
 Asn His Asp Thr Phe Asp Leu His Gly Lys Ile Leu Lys Ser Asn Leu
         115                 120                 125            
 Ser Leu Val Asn Gln Asn Lys Arg Tyr Glu Ile Lys Asn Ser Val Gly
     130                 135                 140                
 Val Asn Gly Asp Gly Lys Ser Phe Leu His Ala Lys His Glu Gln Phe
 145                 150                 155                 160
 His Asn Glu Met Asn Phe Pro Glu Gly Gly Asn Ser Val Asn Thr Asn
                 165                 170                 175    
 Ser Gln Phe Ile Lys His Gln Arg Thr Gln Asn Ile Asp Lys Pro His
             180                 185                 190        
 Val Cys Thr Glu Cys Gly Lys Ala Phe Leu Lys Lys Ser Arg Leu Ile
         195                 200                 205            
 Tyr His Gln Arg Val His Thr Gly Glu Lys Pro His Gly Cys Ser Ile
     210                 215                 220                
 Cys Gly Lys Ala Phe Ser Arg Lys Ser Gly Leu Thr Glu His Gln Arg
 225                 230                 235                 240
 Asn His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Asp Lys Ala
                 245                 250                 255    
 Phe Arg Trp Lys Ser Gln Leu Asn Ala His Gln Lys Ile His Thr Gly
             260                 265                 270        
 Glu Lys Ser Tyr Ile Cys Ser Asp Cys Gly Lys Gly Phe Ile Lys Lys
         275                 280                 285            
 Ser Arg Leu Ile Asn His Gln Arg Val His Thr Gly Glu Lys Pro His
     290                 295                 300                
 Gly Cys Ser Leu Cys Gly Lys Ala Phe Ser Lys Arg Ser Arg Leu Thr
 305                 310                 315                 320
 Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu
                 325                 330                 335    
 Cys Asp Lys Ala Phe Arg Trp Lys Ser Gln Leu Asn Ala His Gln Lys
             340                 345                 350        
 Ala His Thr Gly Glu Lys Ser Tyr Ile Cys Arg Asp Cys Gly Lys Gly
         355                 360                 365            
 Phe Ile Gln Lys Gly Asn Leu Ile Val His Gln Arg Ile His Thr Gly
     370                 375                 380                
 Glu Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Gly Phe Ile Gln Lys
 385                 390                 395                 400
 Gly Asn Leu Leu Ile His Arg Arg Thr His Thr Gly Glu Lys Pro Tyr
                 405                 410                 415    
 Val Cys Asn Glu Cys Gly Lys Gly Phe Ser Gln Lys Thr Cys Leu Ile
             420                 425                 430        
 Ser His Gln Arg Phe His Thr Gly Lys Thr Pro Phe Val Cys Thr Glu
         435                 440                 445            
 Cys Gly Lys Ser Cys Ser His Lys Ser Gly Leu Ile Asn His Gln Arg
     450                 455                 460                
 Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Ser Asp Cys Gly Lys Ala
 465                 470                 475                 480
 Phe Arg Asp Lys Ser Cys Leu Asn Arg His Arg Arg Thr His Thr Gly
                 485                 490                 495    
 Glu Arg Pro Tyr Gly Cys Ser Asp Cys Gly Lys Ala Phe Ser His Leu
             500                 505                 510        
 Ser Cys Leu Val Tyr His Lys Gly Met Leu His Ala Arg Glu Lys Cys
         515                 520                 525            
 Val Gly Ser Val Lys Leu Glu Asn Pro Cys Ser Glu Ser His Ser Leu
     530                 535                 540                
 Ser His Thr Arg Asp Leu Ile Gln Asp Lys Asp Ser Val Asn Met Val
 545                 550                 555                 560
 Thr Leu Gln Met Pro Ser Val Ala Ala Gln Thr Ser Leu Thr Asn Ser
                 565                 570                 575    
 Ala Phe Gln Ala Glu Ser Lys Val Ala Ile Val Ser Gln Pro Val Ala
             580                 585                 590        
 Arg Ser Ser Val Ser Ala Asp Ser Arg Ile Cys Thr Glu
         595                 600                 605



      <210> 863
      <211> 777
      <212> PRT
      <213> Homo sapiens


      <400> 863
 Met Leu Lys Leu Gln Asp Leu Tyr Thr Ser Pro Cys Ala Glu Thr Pro
   1               5                  10                  15    
 Pro Ser Thr Leu Ser Gly Thr Leu Trp Glu Arg Ser Cys Arg Thr Ile
              20                  25                  30        
 Cys Leu Ile Leu Asp Phe Ile Ala Arg Gly Arg Ile Gly Asn Arg Pro
          35                  40                  45            
 Thr Asn Leu Gly Ile Arg Cys Lys Thr Glu Thr Val Gly Ala Ile Gly
      50                  55                  60                
 Pro Val His Gln Gln Leu Lys Ile Leu Pro Asn Ala Glu Gly Lys Lys
  65                  70                  75                  80
 Arg Thr Gly Asp Arg Ala Arg Thr Asn Arg Ser Pro Ala Pro Arg Pro
                  85                  90                  95    
 His Ser Thr Leu Ala Thr Thr Pro Thr His Ser Arg Val Arg Pro Ala
             100                 105                 110        
 Arg Ser Tyr Tyr Phe Ala Ile Phe Ser Asn Met Thr Arg Val Ser Ser
         115                 120                 125            
 Ser Val Lys Gly Arg Ile Phe Pro Pro Gly Leu Glu His Arg Ile Leu
     130                 135                 140                
 Val Pro Cys Ser Glu Ser Ala Pro Leu Val Val Arg Lys Gly Ser Asp
 145                 150                 155                 160
 Val Val Ala Gly Lys Met Ala Thr Ala Ala Thr Ile Pro Ser Val Ala
                 165                 170                 175    
 Thr Ala Thr Ala Ala Ala Leu Gly Glu Val Glu Asp Glu Gly Leu Leu
             180                 185                 190        
 Ala Ser Leu Phe Arg Asp Arg Phe Pro Glu Ala Gln Trp Arg Glu Arg
         195                 200                 205            
 Pro Asp Val Gly Arg Tyr Leu Arg Glu Leu Ser Gly Ser Gly Leu Glu
     210                 215                 220                
 Arg Leu Arg Arg Glu Pro Glu Arg Leu Ala Glu Glu Arg Ala Gln Leu
 225                 230                 235                 240
 Leu Gln Gln Thr Arg Asp Leu Ala Phe Ala Asn Tyr Lys Thr Phe Ile
                 245                 250                 255    
 Arg Gly Ala Glu Cys Thr Glu Arg Ile His Arg Leu Phe Gly Asp Val
             260                 265                 270        
 Glu Ala Ser Leu Gly Arg Leu Leu Asp Arg Leu Pro Ser Phe Gln Gln
         275                 280                 285            
 Ser Cys Arg Asn Phe Val Lys Glu Ala Glu Glu Ile Ser Ser Asn Arg
     290                 295                 300                
 Arg Met Asn Ser Leu Thr Leu Asn Arg His Thr Glu Ile Leu Glu Ile
 305                 310                 315                 320
 Leu Glu Ile Pro Gln Leu Met Asp Thr Cys Val Arg Asn Ser Tyr Tyr
                 325                 330                 335    
 Glu Glu Ala Leu Glu Leu Ala Ala Tyr Val Arg Arg Leu Glu Arg Lys
             340                 345                 350        
 Tyr Ser Ser Ile Pro Val Ile Gln Gly Ile Val Asn Glu Val Arg Gln
         355                 360                 365            
 Ser Met Gln Leu Met Leu Ser Gln Leu Ile Gln Gln Leu Arg Thr Asn
     370                 375                 380                
 Ile Gln Leu Pro Ala Cys Leu Arg Val Ile Gly Tyr Leu Arg Arg Met
 385                 390                 395                 400
 Asp Val Phe Thr Glu Ala Glu Leu Arg Val Lys Phe Leu Gln Ala Arg
                 405                 410                 415    
 Asp Ala Trp Leu Arg Ser Ile Leu Thr Ala Ile Pro Asn Asp Asp Pro
             420                 425                 430        
 Tyr Phe His Ile Thr Lys Thr Ile Glu Ala Ser Arg Val His Leu Phe
         435                 440                 445            
 Asp Ile Ile Thr Gln Tyr Arg Ala Ile Phe Ser Asp Glu Asp Pro Leu
     450                 455                 460                
 Leu Pro Pro Ala Met Gly Glu His Thr Val Asn Glu Ser Ala Ile Phe
 465                 470                 475                 480
 His Gly Trp Val Leu Gln Lys Val Ser Gln Phe Leu Gln Val Leu Glu
                 485                 490                 495    
 Thr Asp Leu Tyr Arg Gly Ile Gly Gly His Leu Asp Ser Leu Leu Gly
             500                 505                 510        
 Gln Cys Met Tyr Phe Gly Leu Ser Phe Ser Arg Val Gly Ala Asp Phe
         515                 520                 525            
 Arg Gly Gln Leu Ala Pro Val Phe Gln Arg Val Ala Ile Ser Thr Phe
     530                 535                 540                
 Gln Lys Ala Ile Gln Glu Thr Val Glu Lys Phe Gln Glu Glu Met Asn
 545                 550                 555                 560
 Ser Tyr Met Leu Ile Ser Ala Pro Ala Ile Leu Gly Thr Ser Asn Met
                 565                 570                 575    
 Pro Ala Ala Val Pro Ala Thr Gln Pro Gly Thr Leu Gln Pro Pro Met
             580                 585                 590        
 Val Leu Leu Asp Phe Pro Pro Leu Ala Cys Phe Leu Asn Asn Ile Leu
         595                 600                 605            
 Val Ala Phe Asn Asp Leu Arg Leu Cys Cys Pro Val Ala Leu Ala Gln
     610                 615                 620                
 Asp Val Thr Gly Ala Leu Glu Asp Ala Leu Ala Lys Val Thr Lys Ile
 625                 630                 635                 640
 Ile Leu Ala Phe His Arg Ala Glu Glu Ala Ala Phe Ser Ser Gly Glu
                 645                 650                 655    
 Gln Glu Leu Phe Val Gln Phe Cys Thr Val Phe Leu Glu Asp Leu Val
             660                 665                 670        
 Pro Tyr Leu Asn Arg Cys Leu Gln Val Leu Phe Pro Pro Ala Gln Ile
         675                 680                 685            
 Ala Gln Thr Leu Gly Ile Pro Pro Thr Gln Leu Ser Lys Tyr Gly Asn
     690                 695                 700                
 Leu Gly His Val Asn Ile Gly Ala Ile Gln Glu Pro Leu Ala Phe Ile
 705                 710                 715                 720
 Leu Pro Lys Arg Glu Thr Leu Phe Thr Leu Asp Asp Gln Ala Leu Gly
                 725                 730                 735    
 Pro Glu Leu Thr Ala Pro Ala Pro Glu Pro Pro Ala Glu Glu Pro Arg
             740                 745                 750        
 Leu Glu Pro Ala Gly Pro Ala Cys Pro Glu Gly Gly Arg Ala Glu Thr
         755                 760                 765            
 Gln Ala Glu Pro Pro Ser Val Gly Pro
     770                 775        



      <210> 864
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 864
 Met Gly Lys Arg Tyr Phe Cys Asp Tyr Cys Asp Arg Ser Phe Gln Asp
   1               5                  10                  15    
 Asn Leu His Asn Arg Lys Lys His Leu Asn Gly Leu Gln His Leu Lys
              20                  25                  30        
 Ala Lys Lys Val Trp Tyr Asp Met Phe Arg Asp Ala Ala Ala Ile Leu
          35                  40                  45            
 Leu Asp Glu Gln Asn Lys Arg Pro Cys Arg Lys Phe Leu Leu Thr Gly
      50                  55                  60                
 Gln Cys Asp Phe Gly Ser Asn Cys Arg Phe Ser His Met Ser Glu Arg
  65                  70                  75                  80
 Asp Leu Gln Glu Leu Ser Ile Gln Val Glu Glu Glu Arg Arg Ala Arg
                  85                  90                  95    
 Glu Trp Leu Leu Asp Ala Pro Glu Leu Pro Glu Gly His Leu Glu Asp
             100                 105                 110        
 Trp Leu Glu Lys Arg Ala Lys Arg Leu Ser Ser Ala Pro Ser Ser Arg
         115                 120                 125            
 Ala Glu Pro Ile Arg Thr Thr Val Phe Gln Tyr Pro Val Gly Trp Pro
     130                 135                 140                
 Pro Val Gln Glu Leu Pro Pro Ser Leu Arg Ala Pro Pro Pro Gly Gly
 145                 150                 155                 160
 Trp Pro Leu Gln Pro Arg Val Gln Trp Gly
                 165                 170



      <210> 865
      <211> 480
      <212> PRT
      <213> Homo sapiens


      <400> 865
 Met Ile Ser Asp Gln Gly Gln Leu Thr His His Leu Thr Ser Ala Asn
   1               5                  10                  15    
 Thr Leu Asn Lys Asp Phe Phe Cys Gly Gly Arg Leu Gly Pro Val Gln
              20                  25                  30        
 Thr Trp Tyr Gln Pro Pro Ala Phe Gln Cys Lys Gly Leu Ala Ala Ala
          35                  40                  45            
 Asp Gly Glu Gly Pro Leu Leu Pro Lys Lys Gln Lys Arg Pro Ala Thr
      50                  55                  60                
 Arg Arg Arg Leu Val His Tyr Leu Lys Gly Arg Glu Val Gly Ala Arg
  65                  70                  75                  80
 Gly Pro Ala Gly Leu Gln Gly Phe Glu Gly Glu Leu Arg Gly Tyr Ala
                  85                  90                  95    
 Val Gln Arg Leu Pro Glu Leu Leu Thr Glu Arg Gln Leu Asp Leu Gly
             100                 105                 110        
 Thr Leu Asn Lys Val Phe Ala Ser Gln Trp Leu Asn Ala Arg Gln Val
         115                 120                 125            
 Val Cys Gly Thr Lys Cys Asn Thr Leu Phe Val Val Asp Val Gln Ser
     130                 135                 140                
 Gly His Ile Thr Arg Ile Pro Leu Met Arg Asp Lys Glu Ala Gly Leu
 145                 150                 155                 160
 Ala Gln Ala His Gln Gly Cys Gly Ile His Ala Ile Glu Leu Asn Pro
                 165                 170                 175    
 Ser Lys Thr Leu Leu Ala Thr Gly Gly Glu Asn Pro Asn Ser Leu Ala
             180                 185                 190        
 Ile Tyr Gln Leu Pro Thr Leu Asp Pro Leu Cys Leu Gly Asp Arg His
         195                 200                 205            
 Gly His Lys Asp Trp Ile Phe Ala Val Ala Trp Leu Ser Asp Thr Val
     210                 215                 220                
 Ala Val Ser Gly Ser Arg Asp Gly Thr Val Ala Leu Trp Arg Met Asp
 225                 230                 235                 240
 Pro Asp Met Phe Asn Gly Ser Ile Ala Trp His Ser Glu Val Gly Leu
                 245                 250                 255    
 Pro Val Tyr Ala His Ile Arg Pro Arg Asp Val Glu Ala Ile Pro Arg
             260                 265                 270        
 Ala Ser Thr Asn Pro Ser Asn Arg Lys Val Arg Ala Leu Ala Phe Ser
         275                 280                 285            
 Gly Lys Asn Gln Glu Leu Gly Ala Val Ser Leu Asp Gly Tyr Phe His
     290                 295                 300                
 Leu Trp Lys Ala Arg Ser Thr Leu Ser Arg Leu Leu Ser Ile Arg Leu
 305                 310                 315                 320
 Pro Tyr Cys Arg Glu Asn Val Cys Leu Thr Tyr Cys Asp Glu Leu Ser
                 325                 330                 335    
 Leu Tyr Ala Val Gly Ser Gln Ser His Val Ser Phe Leu Asp Pro Arg
             340                 345                 350        
 Gln Arg Gln Gln Asn Ile Arg Pro Leu Cys Ser Arg Glu Gly Gly Thr
         355                 360                 365            
 Gly Val Arg Ser Leu Ser Phe Tyr Gln His Ile Ile Thr Val Gly Thr
     370                 375                 380                
 Gly His Gly Ser Leu Leu Phe Tyr Asp Ile Arg Ala Gln Lys Phe Leu
 385                 390                 395                 400
 Glu Glu Arg Ala Ser Ser Ser Leu Asp Ser Met Pro Gly Pro Ala Gly
                 405                 410                 415    
 Arg Lys Leu Lys Leu Ala Cys Gly Arg Gly Trp Leu Asn Gln Asp Asp
             420                 425                 430        
 Val Trp Val Asn Tyr Phe Gly Gly Met Gly Glu Phe Pro Asn Ala Leu
         435                 440                 445            
 Tyr Thr His Cys Tyr Asn Trp Pro Glu Met Lys Leu Phe Val Ala Gly
     450                 455                 460                
 Gly Pro Leu Pro Ser Gly Leu His Gly Asn Tyr Ala Gly Leu Trp Ser
 465                 470                 475                 480





      <210> 866
      <211> 491
      <212> PRT
      <213> Homo sapiens


      <400> 866
 Met Ile Ala Thr Gly Gly Val Ile Thr Gly Leu Ala Ala Leu Lys Arg
   1               5                  10                  15    
 Gln Asp Ser Ala Arg Ser Gln Gln His Val Asn Leu Ser Pro Ser Pro
              20                  25                  30        
 Ala Thr Gln Glu Lys Lys Pro Ile Arg Arg Arg Pro Arg Ala Asp Val
          35                  40                  45            
 Val Val Val Arg Gly Lys Ile Arg Leu Tyr Ser Pro Ser Gly Phe Phe
      50                  55                  60                
 Leu Ile Leu Gly Val Leu Ile Ser Ile Ile Gly Ile Ala Met Ala Val
  65                  70                  75                  80
 Leu Gly Tyr Trp Pro Gln Lys Glu His Phe Ile Asp Ala Glu Thr Thr
                  85                  90                  95    
 Leu Ser Thr Asn Glu Thr Gln Val Ile Arg Asn Glu Gly Gly Val Val
             100                 105                 110        
 Val Arg Phe Phe Glu Gln His Leu His Ser Asp Lys Met Lys Met Leu
         115                 120                 125            
 Gly Pro Phe Thr Met Gly Ile Gly Ile Phe Ile Phe Ile Cys Ala Asn
     130                 135                 140                
 Ala Ile Leu His Glu Asn Arg Asp Lys Glu Thr Lys Ile Ile His Met
 145                 150                 155                 160
 Arg Asp Ile Tyr Ser Thr Val Ile Asp Ile His Thr Leu Arg Ile Lys
                 165                 170                 175    
 Glu Gln Arg Gln Met Asn Gly Met Tyr Thr Gly Leu Met Gly Glu Thr
             180                 185                 190        
 Glu Val Lys Gln Asn Gly Ser Ser Cys Ala Ser Arg Leu Ala Ala Asn
         195                 200                 205            
 Thr Ile Ala Ser Phe Ser Gly Phe Arg Ser Ser Phe Arg Met Asp Ser
     210                 215                 220                
 Ser Val Glu Glu Asp Glu Leu Met Leu Asn Glu Gly Lys Ser Ser Gly
 225                 230                 235                 240
 His Leu Met Pro Pro Leu Leu Ser Asp Ser Ser Val Ser Val Phe Gly
                 245                 250                 255    
 Leu Tyr Pro Pro Pro Ser Lys Thr Thr Asp Asp Lys Thr Ser Gly Ser
             260                 265                 270        
 Lys Lys Cys Glu Thr Lys Ser Ile Val Ser Ser Ser Ile Ser Ala Phe
         275                 280                 285            
 Thr Leu Pro Val Ile Lys Leu Asn Asn Cys Val Ile Asp Glu Pro Ser
     290                 295                 300                
 Ile Asp Asn Ile Thr Glu Asp Ala Asp Asn Leu Lys Ser Arg Ser Arg
 305                 310                 315                 320
 Asn Leu Ser Met Asp Ser Leu Val Val Pro Leu Pro Asn Thr Ser Glu
                 325                 330                 335    
 Ser Phe Gln Pro Val Ser Thr Val Leu Pro Arg Asn Asn Ser Ile Gly
             340                 345                 350        
 Glu Ser Leu Ser Ser Gln Tyr Lys Ser Ser Met Ala Leu Gly Pro Gly
         355                 360                 365            
 Ala Gly Gln Leu Leu Ser Pro Gly Ala Ala Arg Arg Gln Phe Gly Ser
     370                 375                 380                
 Asn Thr Ser Leu His Leu Leu Ser Ser His Ser Lys Ser Leu Asp Leu
 385                 390                 395                 400
 Asp Arg Gly Pro Ser Thr Leu Thr Val Gln Ala Glu Gln Arg Lys His
                 405                 410                 415    
 Pro Ser Trp Pro Arg Leu Asp Arg Asn Asn Ser Lys Gly Tyr Met Lys
             420                 425                 430        
 Leu Glu Asn Lys Glu Asp Pro Met Asp Arg Leu Leu Val Pro Gln Val
         435                 440                 445            
 Ala Ile Lys Lys Asp Phe Thr Asn Lys Glu Lys Leu Leu Met Ile Ser
     450                 455                 460                
 Arg Ser His Asn Asn Leu Ser Phe Glu His Asp Glu Phe Leu Ser Asn
 465                 470                 475                 480
 Asn Leu Lys Arg Gly Thr Ser Glu Thr Arg Phe
                 485                 490    



      <210> 867
      <211> 514
      <212> PRT
      <213> Homo sapiens


      <400> 867
 Met Thr Leu Ile Trp Arg His Leu Leu Arg Pro Leu Cys Leu Val Thr
   1               5                  10                  15    
 Ser Ala Pro Arg Ile Leu Glu Met His Pro Phe Leu Ser Leu Gly Thr
              20                  25                  30        
 Ser Arg Thr Ser Val Thr Lys Leu Ser Leu His Thr Lys Pro Arg Met
          35                  40                  45            
 Pro Pro Cys Asp Phe Met Pro Glu Arg Tyr Gln Ser Leu Gly Tyr Asn
      50                  55                  60                
 Arg Val Leu Glu Ile His Lys Glu His Leu Ser Pro Val Val Thr Ala
  65                  70                  75                  80
 Tyr Phe Gln Lys Pro Leu Leu Leu His Gln Gly His Met Glu Trp Leu
                  85                  90                  95    
 Phe Asp Ala Glu Gly Ser Arg Tyr Leu Asp Phe Phe Ser Gly Ile Val
             100                 105                 110        
 Thr Val Ser Val Gly His Cys His Pro Lys Val Asn Ala Val Ala Gln
         115                 120                 125            
 Lys Gln Leu Gly Arg Leu Trp His Thr Ser Thr Val Phe Phe His Pro
     130                 135                 140                
 Pro Met His Glu Tyr Ala Glu Lys Leu Ala Ala Leu Leu Pro Glu Pro
 145                 150                 155                 160
 Leu Lys Val Ile Phe Leu Val Asn Ser Gly Ser Glu Ala Asn Glu Leu
                 165                 170                 175    
 Ala Met Leu Met Ala Arg Ala His Ser Asn Asn Ile Asp Ile Ile Ser
             180                 185                 190        
 Phe Arg Gly Ala Tyr His Gly Cys Ser Pro Tyr Thr Leu Gly Leu Thr
         195                 200                 205            
 Asn Val Gly Thr Tyr Lys Met Glu Leu Pro Gly Gly Thr Gly Cys Gln
     210                 215                 220                
 Pro Thr Met Cys Pro Asp Val Phe Arg Gly Pro Trp Gly Gly Ser His
 225                 230                 235                 240
 Cys Arg Asp Ser Pro Val Gln Thr Ile Arg Lys Cys Ser Cys Ala Pro
                 245                 250                 255    
 Asp Cys Cys Gln Ala Lys Asp Gln Tyr Ile Glu Gln Phe Lys Asp Thr
             260                 265                 270        
 Leu Ser Thr Ser Val Ala Lys Ser Ile Ala Gly Phe Phe Ala Glu Pro
         275                 280                 285            
 Ile Gln Gly Val Asn Gly Val Val Gln Tyr Pro Lys Gly Phe Leu Lys
     290                 295                 300                
 Glu Ala Phe Glu Leu Val Arg Ala Arg Gly Gly Val Cys Ile Ala Asp
 305                 310                 315                 320
 Glu Val Gln Thr Gly Phe Gly Arg Leu Gly Ser His Phe Trp Gly Phe
                 325                 330                 335    
 Gln Thr His Asp Val Leu Pro Asp Ile Val Thr Met Ala Lys Gly Ile
             340                 345                 350        
 Gly Asn Gly Phe Pro Met Ala Ala Val Ile Thr Thr Pro Glu Ile Ala
         355                 360                 365            
 Lys Ser Leu Ala Lys Cys Leu Gln His Phe Asn Thr Phe Gly Gly Asn
     370                 375                 380                
 Pro Met Ala Cys Ala Ile Gly Ser Ala Val Leu Glu Val Ile Lys Glu
 385                 390                 395                 400
 Glu Asn Leu Gln Glu Asn Ser Gln Glu Val Gly Thr Tyr Met Leu Leu
                 405                 410                 415    
 Lys Phe Ala Lys Leu Arg Asp Glu Phe Glu Ile Val Gly Asp Val Arg
             420                 425                 430        
 Gly Lys Gly Leu Met Ile Gly Ile Glu Met Val Gln Asp Lys Ile Ser
         435                 440                 445            
 Cys Arg Pro Leu Pro Arg Glu Glu Val Asn Gln Ile His Glu Asp Cys
     450                 455                 460                
 Lys His Met Gly Leu Leu Val Gly Arg Gly Ser Ile Phe Ser Gln Thr
 465                 470                 475                 480
 Phe Arg Ile Ala Pro Ser Met Cys Ile Thr Lys Pro Glu Val Asp Phe
                 485                 490                 495    
 Ala Val Glu Val Phe Arg Ser Ala Leu Thr Gln His Met Glu Arg Arg
             500                 505                 510        
 Ala Lys
        



      <210> 868
      <211> 411
      <212> PRT
      <213> Homo sapiens


      <400> 868
 Met Thr Leu Ile Trp Arg His Leu Leu Arg Pro Leu Cys Leu Val Thr
   1               5                  10                  15    
 Ser Ala Pro Arg Ile Leu Glu Met His Pro Phe Leu Ser Leu Gly Thr
              20                  25                  30        
 Ser Arg Thr Ser Val Thr Lys Leu Ser Leu His Thr Lys Pro Arg Met
          35                  40                  45            
 Pro Pro Cys Asp Phe Met Pro Glu Arg Tyr Gln Val Ile Phe Leu Val
      50                  55                  60                
 Asn Ser Gly Ser Glu Ala Asn Glu Leu Ala Met Leu Met Ala Arg Ala
  65                  70                  75                  80
 His Ser Asn Asn Ile Asp Ile Ile Ser Phe Arg Gly Ala Tyr His Gly
                  85                  90                  95    
 Cys Ser Pro Tyr Thr Leu Gly Leu Thr Asn Val Gly Ile Tyr Lys Met
             100                 105                 110        
 Glu Leu Pro Gly Gly Thr Gly Cys Gln Pro Thr Met Cys Pro Asp Val
         115                 120                 125            
 Phe Arg Gly Pro Trp Gly Gly Ser His Cys Arg Asp Ser Pro Val Gln
     130                 135                 140                
 Thr Ile Arg Lys Cys Ser Cys Ala Pro Asp Cys Cys Gln Ala Lys Asp
 145                 150                 155                 160
 Gln Tyr Ile Glu Gln Phe Lys Asp Thr Leu Ser Thr Ser Val Ala Lys
                 165                 170                 175    
 Ser Ile Ala Gly Phe Phe Ala Glu Pro Ile Gln Gly Val Asn Gly Val
             180                 185                 190        
 Val Gln Tyr Pro Lys Gly Phe Leu Lys Glu Ala Phe Glu Leu Val Arg
         195                 200                 205            
 Ala Arg Gly Gly Val Cys Ile Ala Asp Glu Val Gln Thr Gly Phe Gly
     210                 215                 220                
 Arg Leu Gly Ser His Phe Trp Gly Phe Gln Thr His Asp Val Leu Pro
 225                 230                 235                 240
 Asp Ile Val Thr Met Ala Lys Gly Ile Gly Asn Gly Phe Pro Met Ala
                 245                 250                 255    
 Ala Val Ile Thr Thr Pro Glu Ile Ala Lys Ser Leu Ala Lys Cys Leu
             260                 265                 270        
 Gln His Phe Asn Thr Phe Gly Gly Asn Pro Met Ala Cys Ala Ile Gly
         275                 280                 285            
 Ser Ala Val Leu Glu Val Ile Lys Glu Glu Asn Leu Gln Glu Asn Ser
     290                 295                 300                
 Gln Glu Val Gly Thr Tyr Met Leu Leu Lys Phe Ala Lys Leu Arg Asp
 305                 310                 315                 320
 Glu Phe Glu Ile Val Gly Asp Val Arg Gly Lys Gly Leu Met Ile Gly
                 325                 330                 335    
 Ile Glu Met Val Gln Asp Lys Ile Ser Cys Arg Pro Leu Pro Arg Glu
             340                 345                 350        
 Glu Val Asn Gln Ile His Glu Asp Cys Lys His Met Gly Leu Leu Val
         355                 360                 365            
 Gly Arg Gly Ser Ile Phe Ser Gln Thr Phe Arg Ile Ala Pro Ser Met
     370                 375                 380                
 Cys Ile Thr Lys Pro Glu Val Asp Phe Ala Val Glu Val Phe Arg Ser
 385                 390                 395                 400
 Ala Leu Thr Gln His Met Glu Arg Arg Ala Lys
                 405                 410    



      <210> 869
      <211> 328
      <212> PRT
      <213> Homo sapiens


      <400> 869
 Met Leu Met Cys Arg Gln Pro Met Lys Arg Trp Lys Asp Arg Arg Thr
   1               5                  10                  15    
 Gly Leu Leu Leu Pro Leu Val Leu Leu Leu Phe Gly Ala Cys Ser Ser
              20                  25                  30        
 Leu Ala Trp Val Cys Gly Arg Arg Met Ser Ser Arg Ser Gln Gln Leu
          35                  40                  45            
 Asn Asn Ala Ser Ala Ile Val Glu Gly Lys Pro Ala Ser Ala Ile Val
      50                  55                  60                
 Gly Gly Lys Pro Ala Asn Ile Leu Glu Phe Pro Trp His Val Gly Ile
  65                  70                  75                  80
 Met Asn His Gly Ser His Leu Cys Gly Gly Ser Ile Leu Asn Glu Trp
                  85                  90                  95    
 Trp Val Leu Ser Ala Ser His Cys Phe Asp Gln Leu Asn Asn Ser Lys
             100                 105                 110        
 Leu Glu Ile Ile His Gly Thr Glu Asp Leu Ser Thr Lys Gly Ile Lys
         115                 120                 125            
 Tyr Gln Lys Val Asp Lys Leu Phe Leu His Pro Lys Phe Asp Asp Trp
     130                 135                 140                
 Leu Leu Asp Asn Asp Ile Ala Leu Leu Leu Leu Lys Ser Pro Leu Asn
 145                 150                 155                 160
 Leu Ser Val Asn Arg Ile Pro Ile Cys Thr Ser Glu Ile Ser Asp Ile
                 165                 170                 175    
 Gln Ala Trp Arg Asn Cys Trp Val Thr Gly Trp Gly Ile Thr Asn Thr
             180                 185                 190        
 Ser Glu Lys Gly Val Gln Pro Thr Ile Leu Gln Ala Val Lys Val Asp
         195                 200                 205            
 Leu Tyr Arg Trp Asp Trp Cys Gly Tyr Ile Leu Ser Leu Leu Thr Lys
     210                 215                 220                
 Asn Met Leu Cys Ala Gly Thr Gln Asp Pro Gly Lys Asp Ala Cys Gln
 225                 230                 235                 240
 Gly Asp Ser Gly Gly Ala Leu Val Cys Asn Lys Lys Arg Asn Thr Ala
                 245                 250                 255    
 Ile Trp Tyr Gln Val Gly Ile Val Ser Trp Gly Met Gly Cys Gly Lys
             260                 265                 270        
 Lys Asn Leu Pro Gly Val Tyr Thr Lys Val Ser His Tyr Val Arg Trp
         275                 280                 285            
 Ile Ser Lys Gln Thr Ala Lys Ala Gly Arg Pro Tyr Met Tyr Glu Gln
     290                 295                 300                
 Asn Ser Ala Cys Pro Leu Val Leu Ser Cys Arg Ala Ile Leu Val Leu
 305                 310                 315                 320
 Tyr Phe Gly Met Phe Leu Leu Thr
                 325            



      <210> 870
      <211> 266
      <212> PRT
      <213> Homo sapiens


      <400> 870
 Met Arg Leu Leu Phe Leu Ala Val Leu Arg Pro His Thr Gly Asn Ala
   1               5                  10                  15    
 Val Thr Ala Gln Arg Val Arg Ala His Leu Glu Ala Ala Gly His Val
              20                  25                  30        
 Cys Val Leu Lys Asp Ala Phe Asp Phe Glu Ser Arg Ser Glu Ile Ala
          35                  40                  45            
 Asn Leu Ile Leu Ala Glu Asn Cys Glu Ala Ala Leu Ala Leu His Leu
      50                  55                  60                
 Tyr Arg Gly Gly Arg Leu Leu Gln Gly His Arg Ile Pro Phe Gly Val
  65                  70                  75                  80
 Ile Phe Gly Gly Thr Asp Val Asn Glu Asp Ala Asn Gln Ala Glu Lys
                  85                  90                  95    
 Asn Thr Val Met Gly Arg Val Leu Glu Glu Ala Arg Phe Ala Val Ala
             100                 105                 110        
 Phe Thr Glu Ser Met Lys Glu Met Ala Gln Ala Gln Trp Val Asp Pro
         115                 120                 125            
 Val Phe Thr Arg Glu Val Lys Ala Lys Val Lys Arg Ala Ala Gly Val
     130                 135                 140                
 Arg Leu Ile Gly Glu Met Pro Gln Glu Asp Leu His Ala Val Val Lys
 145                 150                 155                 160
 Asn Cys Phe Ala Val Val Asn Ser Ser Val Ser Glu Gly Met Ser Ala
                 165                 170                 175    
 Ala Ile Leu Glu Ala Met Asp Leu Glu Val Pro Val Leu Ala Arg Asn
             180                 185                 190        
 Ile Pro Gly Asn Ala Ala Val Val Lys His Glu Val Thr Gly Leu Leu
         195                 200                 205            
 Phe Ser Asn Pro Gln Glu Phe Val His Leu Ala Lys Arg Leu Val Ser
     210                 215                 220                
 Asp Pro Ala Leu Glu Lys Glu Ile Val Val Asn Gly Arg Glu Tyr Val
 225                 230                 235                 240
 Arg Met Tyr His Ser Trp Gln Val Glu Arg Asp Thr Tyr Gln Gln Leu
                 245                 250                 255    
 Ile Arg Lys Leu Glu Gly Ser Thr Glu Asp
             260                 265    



      <210> 871
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 871
 Met Arg Glu Leu Leu Asn Lys Thr Thr Phe Tyr Leu Pro Met Ala Arg
   1               5                  10                  15    
 Gln Val Phe Phe Gln Leu Ser Pro Ile His Pro Val Pro Ser Asn Leu
              20                  25                  30        
 Ser Met Gly Trp Asn Leu Thr Leu Gly Met Thr Phe Gly Ile Val Val
          35                  40                  45            
 Asp Leu Thr Pro Val Phe Val Leu Val Leu Phe Leu Pro Ala Phe Leu
      50                  55                  60                
 Phe Leu Ser Leu Pro Ser Trp Ser Leu Pro Arg Asp Pro Thr His Val
  65                  70                  75                  80
 Lys Tyr Gly Leu Glu Asp Cys Met Asn Ala Ser
                  85                  90    



      <210> 872
      <211> 378
      <212> PRT
      <213> Homo sapiens


      <400> 872
 Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val
   1               5                  10                  15    
 Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro
              20                  25                  30        
 Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu
          35                  40                  45            
 Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile
      50                  55                  60                
 Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu
  65                  70                  75                  80
 Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser
                  85                  90                  95    
 Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr
             100                 105                 110        
 Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val
         115                 120                 125            
 Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala
     130                 135                 140                
 Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro
 145                 150                 155                 160
 Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala
                 165                 170                 175    
 Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu
             180                 185                 190        
 Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met
         195                 200                 205            
 Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu
     210                 215                 220                
 Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr
 225                 230                 235                 240
 Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr
                 245                 250                 255    
 Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro
             260                 265                 270        
 Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly
         275                 280                 285            
 Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val
     290                 295                 300                
 Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys
 305                 310                 315                 320
 Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val
                 325                 330                 335    
 Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr
             340                 345                 350        
 Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp
         355                 360                 365            
 Gln Lys Lys Lys Lys Lys Lys Ile Phe Phe
     370                 375            



      <210> 873
      <211> 1148
      <212> PRT
      <213> Homo sapiens


      <400> 873
 Met Ser Ala Ala Ser Val Cys Leu Ala Leu Arg Pro Cys Leu Asn Gly
   1               5                  10                  15    
 Gly Lys Cys Ile Asp Asp Cys Val Thr Gly Asn Pro Ser Tyr Thr Cys
              20                  25                  30        
 Ser Cys Leu Ser Gly Phe Thr Gly Arg Arg Cys His Leu Asp Val Asn
          35                  40                  45            
 Glu Cys Ala Ser Gln Pro Cys Gln Asn Gly Gly Thr Cys Thr His Gly
      50                  55                  60                
 Ile Asn Ser Phe Arg Cys Gln Cys Pro Ala Gly Phe Gly Gly Pro Thr
  65                  70                  75                  80
 Cys Glu Thr Ala Gln Ser Pro Cys Asp Thr Lys Glu Cys Gln His Gly
                  85                  90                  95    
 Gly Gln Cys Gln Val Glu Asn Gly Ser Ala Val Cys Val Cys Gln Ala
             100                 105                 110        
 Gly Tyr Thr Gly Ala Ala Cys Glu Met Asp Val Asp Asp Cys Ser Pro
         115                 120                 125            
 Asp Pro Cys Leu Asn Gly Gly Ser Cys Val Asp Leu Val Gly Asn Tyr
     130                 135                 140                
 Thr Cys Leu Cys Ala Glu Pro Phe Lys Gly Leu Arg Cys Glu Thr Gly
 145                 150                 155                 160
 Asp His Pro Val Pro Asp Ala Cys Leu Ser Ala Pro Cys His Asn Gly
                 165                 170                 175    
 Gly Thr Cys Val Asp Ala Asp Gln Gly Tyr Val Cys Glu Cys Pro Glu
             180                 185                 190        
 Gly Phe Met Gly Leu Asp Cys Arg Glu Arg Val Pro Asp Asp Cys Glu
         195                 200                 205            
 Cys Arg Asn Gly Gly Arg Cys Leu Gly Ala Asn Thr Thr Leu Cys Gln
     210                 215                 220                
 Cys Pro Leu Gly Phe Phe Gly Leu Leu Cys Glu Phe Glu Ile Thr Ala
 225                 230                 235                 240
 Met Pro Cys Asn Met Asn Thr Gln Cys Pro Asp Gly Gly Tyr Cys Met
                 245                 250                 255    
 Glu His Gly Gly Ser Tyr Leu Cys Val Cys His Thr Asp His Asn Ala
             260                 265                 270        
 Ser His Ser Leu Pro Ser Pro Cys Asp Ser Asp Pro Cys Phe Asn Gly
         275                 280                 285            
 Gly Ser Cys Asp Ala His Asp Asp Ser Tyr Thr Cys Glu Cys Pro Arg
     290                 295                 300                
 Gly Phe His Gly Lys His Cys Glu Lys Ala Arg Pro His Leu Cys Ser
 305                 310                 315                 320
 Ser Gly Pro Cys Arg Asn Gly Gly Thr Cys Lys Glu Ala Gly Gly Glu
                 325                 330                 335    
 Tyr His Cys Ser Cys Pro Tyr Arg Phe Thr Gly Arg His Cys Glu Ile
             340                 345                 350        
 Gly Lys Pro Asp Ser Cys Ala Ser Gly Pro Cys His Asn Gly Gly Thr
         355                 360                 365            
 Cys Phe His Tyr Ile Gly Lys Tyr Lys Cys Asp Cys Pro Pro Gly Phe
     370                 375                 380                
 Ser Gly Arg His Cys Glu Ile Ala Pro Ser Pro Cys Phe Arg Ser Pro
 385                 390                 395                 400
 Cys Val Asn Gly Gly Thr Cys Glu Asp Arg Asp Thr Asp Phe Phe Cys
                 405                 410                 415    
 His Cys Gln Ala Gly Tyr Met Gly Arg Arg Cys Gln Ala Glu Val Asp
             420                 425                 430        
 Cys Gly Pro Pro Glu Glu Val Lys His Ala Thr Leu Arg Phe Asn Gly
         435                 440                 445            
 Thr Arg Leu Gly Ala Val Ala Leu Tyr Ala Cys Asp Arg Gly Tyr Ser
     450                 455                 460                
 Leu Ser Ala Pro Ser Arg Ile Arg Val Cys Gln Pro His Gly Val Trp
 465                 470                 475                 480
 Ser Glu Pro Pro Gln Cys Leu Glu Ile Asp Glu Cys Arg Ser Gln Pro
                 485                 490                 495    
 Cys Leu His Gly Gly Ser Cys Gln Asp Arg Val Ala Gly Tyr Leu Cys
             500                 505                 510        
 Leu Cys Ser Thr Gly Tyr Glu Gly Ala His Cys Glu Leu Glu Arg Asp
         515                 520                 525            
 Glu Cys Arg Ala His Pro Cys Arg Asn Gly Gly Ser Cys Arg Asn Leu
     530                 535                 540                
 Pro Gly Ala Tyr Val Cys Arg Cys Pro Ala Gly Phe Val Gly Val His
 545                 550                 555                 560
 Cys Glu Thr Glu Val Asp Ala Cys Asp Ser Ser Pro Cys Gln His Gly
                 565                 570                 575    
 Gly Arg Cys Glu Ser Gly Gly Gly Ala Tyr Leu Cys Val Cys Pro Glu
             580                 585                 590        
 Ser Phe Phe Gly Tyr His Cys Glu Thr Val Ser Asp Pro Cys Phe Ser
         595                 600                 605            
 Ser Pro Cys Gly Gly Arg Gly Tyr Cys Leu Ala Ser Asn Gly Ser His
     610                 615                 620                
 Ser Cys Thr Cys Lys Val Gly Tyr Thr Gly Glu Asp Cys Ala Lys Glu
 625                 630                 635                 640
 Leu Phe Pro Pro Thr Ala Leu Lys Met Glu Arg Val Glu Glu Ser Gly
                 645                 650                 655    
 Val Ser Ile Ser Trp Asn Pro Pro Asn Gly Pro Ala Ala Arg Gln Met
             660                 665                 670        
 Leu Asp Gly Tyr Ala Val Thr Tyr Val Ser Ser Asp Gly Ser Tyr Arg
         675                 680                 685            
 Arg Thr Asp Phe Val Asp Arg Thr Arg Ser Ser His Gln Leu Gln Ala
     690                 695                 700                
 Leu Ala Ala Gly Arg Ala Tyr Asn Ile Ser Val Phe Ser Val Lys Arg
 705                 710                 715                 720
 Asn Ser Asn Asn Lys Asn Asp Ile Ser Arg Pro Ala Val Leu Leu Ala
                 725                 730                 735    
 Arg Thr Arg Pro Arg Pro Val Glu Gly Phe Glu Val Thr Asn Val Thr
             740                 745                 750        
 Ala Ser Thr Ile Ser Val Gln Trp Ala Leu His Arg Ile Arg His Ala
         755                 760                 765            
 Thr Val Ser Gly Val Arg Val Ser Ile Arg His Pro Glu Ala Leu Arg
     770                 775                 780                
 Asp Gln Ala Thr Asp Val Asp Arg Ser Val Asp Arg Phe Thr Phe Arg
 785                 790                 795                 800
 Ala Leu Leu Pro Gly Lys Arg Tyr Thr Ile Gln Leu Thr Thr Leu Ser
                 805                 810                 815    
 Gly Leu Arg Gly Glu Glu His Pro Thr Glu Ser Leu Ala Thr Ala Pro
             820                 825                 830        
 Thr His Val Trp Thr Arg Pro Leu Pro Pro Ala Asn Leu Thr Ala Ala
         835                 840                 845            
 Arg Val Thr Ala Thr Ser Ala His Val Val Trp Asp Ala Pro Thr Pro
     850                 855                 860                
 Gly Ser Leu Leu Glu Ala Tyr Val Ile Asn Val Thr Thr Ser Gln Ser
 865                 870                 875                 880
 Thr Lys Ser Arg Tyr Val Pro Asn Gly Lys Leu Ala Ser Tyr Thr Val
                 885                 890                 895    
 Arg Asp Leu Leu Pro Gly Arg Arg Tyr Gln Leu Ser Val Ile Ala Val
             900                 905                 910        
 Gln Ser Thr Glu Leu Gly Pro Gln His Ser Glu Pro Ala His Leu Tyr
         915                 920                 925            
 Ile Ile Thr Ser Pro Arg Asp Gly Ala Asp Arg Arg Trp His Gln Gly
     930                 935                 940                
 Gly His His Pro Arg Val Leu Lys Asn Arg Pro Pro Pro Ala Arg Leu
 945                 950                 955                 960
 Pro Glu Leu Arg Leu Leu Asn Asp His Ser Ala Pro Glu Thr Pro Thr
                 965                 970                 975    
 Gln Pro Pro Arg Phe Ser Glu Leu Val Asp Gly Arg Gly Arg Val Ser
             980                 985                 990        
 Ala Arg Phe Gly Gly Ser Pro Ser Lys Ala Ala Thr Val Arg Ser Gln
         995                1000                1005            
 Pro Thr Ala Ser Ala Gln Leu Glu Asn Met Glu Glu Ala Pro Lys Arg
    1010                1015                1020                
 Val Ser Leu Ala Leu Gln Leu Pro Glu His Gly Ser Lys Asp Ile Gly
1025                1030                1035                1040
 Asn Val Pro Gly Asn Cys Ser Glu Asn Pro Cys Gln Asn Gly Gly Thr
                1045                1050                1055    
 Cys Val Pro Gly Ala Asp Ala His Ser Cys Asp Cys Gly Pro Gly Phe
            1060                1065                1070        
 Lys Gly Arg Arg Cys Glu Leu Ala Cys Ile Lys Val Ser Arg Pro Cys
        1075                1080                1085            
 Thr Arg Leu Phe Ser Glu Thr Lys Ala Phe Pro Val Trp Glu Gly Gly
    1090                1095                1100                
 Val Cys His His Val Tyr Lys Arg Val Tyr Arg Val His Gln Asp Ile
1105                1110                1115                1120
 Cys Phe Lys Glu Ser Cys Glu Ser Thr Ser Leu Lys Lys Thr Pro Asn
                1125                1130                1135    
 Arg Lys Gln Ser Lys Ser Gln Thr Leu Glu Lys Ser
            1140                1145            



      <210> 874
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 874
 Met Gly Ala Arg Pro Trp Ala Val Gly Val His Gln Glu Pro Ala Ala
   1               5                  10                  15    
 Asp His Pro Leu Trp Pro Arg Thr Ser Ser Ser Leu Cys His Ser Cys
              20                  25                  30        
 Ser Ser Glu Thr Gly Val Gly Ala Ser Arg Lys Asp Met Ser Ser Ser
          35                  40                  45            
 Gly Ser Arg Phe Ser Gln His Trp Gly Gln Gly Lys Arg Thr Arg Thr
      50                  55                  60                
 Gly Leu Gly Glu Ala Ser Lys Ala Pro Arg Gly Val Gln Ala Pro Met
  65                  70                  75                  80
 Arg Leu Ser Gly Gly Gly Gly Ser Ser Gln Val Pro Gln Gly Met Gly
                  85                  90                  95    
 Ala Thr Tyr Cys His Pro Gly His Pro Asp Val Phe Ser Gln Val Gln
             100                 105                 110        
 Ser Pro Arg Leu Gly Arg Arg Lys Val Glu Ala Ser Ser His Ser Cys
         115                 120                 125            
 Arg Val Ser Gly Arg Ser Leu Cys His Ser Gly Pro Gln Ser Ser His
     130                 135                 140                
 Leu Ser Ser Gly Thr Asn Ile Pro Asp His Ser Pro Pro Ala
 145                 150                 155            



      <210> 875
      <211> 508
      <212> PRT
      <213> Homo sapiens


      <400> 875
 Met Glu Lys Trp Asp Gly Asn Glu Gly Thr Ser Ala Phe His Met Pro
   1               5                  10                  15    
 Glu Trp Met Ile Gln Phe Ala Asp Gln Lys Gln Glu Phe Asn Lys Arg
              20                  25                  30        
 Pro Thr Lys Ile Gly Arg Arg Ser Leu Ser Arg Ser Ile Ser Gln Ser
          35                  40                  45            
 Ser Thr Asp Ser Tyr Ser Ser Ala Ala Ser Tyr Thr Asp Ser Ser Asp
      50                  55                  60                
 Asp Glu Thr Ser Pro Arg Asp Lys Gln Gln Lys Asn Ser Lys Gly Ser
  65                  70                  75                  80
 Ser Asp Phe Cys Val Lys Asn Ile Lys Gln Ala Glu Phe Gly Arg Arg
                  85                  90                  95    
 Glu Ile Glu Ile Ala Glu Gln Glu Met Pro Ala Leu Met Ala Leu Arg
             100                 105                 110        
 Lys Arg Ala Gln Gly Glu Lys Pro Leu Ala Gly Ala Lys Ile Val Gly
         115                 120                 125            
 Cys Thr His Ile Thr Ala Gln Thr Ala Val Leu Met Glu Thr Leu Gly
     130                 135                 140                
 Ala Leu Gly Ala Gln Cys Arg Trp Ala Ala Cys Asn Ile Tyr Ser Thr
 145                 150                 155                 160
 Leu Asn Glu Val Ala Ala Ala Leu Ala Glu Ser Gly Phe Pro Val Phe
                 165                 170                 175    
 Ala Trp Lys Gly Glu Ser Glu Asp Asp Phe Trp Trp Cys Ile Asp Arg
             180                 185                 190        
 Cys Val Asn Val Glu Gly Trp Gln Pro Asn Met Ile Leu Asp Asp Gly
         195                 200                 205            
 Gly Asp Leu Thr His Trp Ile Tyr Lys Lys Tyr Pro Asn Met Phe Lys
     210                 215                 220                
 Lys Ile Lys Gly Ile Val Glu Glu Ser Val Thr Gly Val His Arg Leu
 225                 230                 235                 240
 Tyr Gln Leu Ser Lys Ala Gly Lys Leu Cys Val Pro Ala Met Asn Val
                 245                 250                 255    
 Asn Asp Ser Val Thr Lys Gln Lys Phe Asp Asn Leu Tyr Cys Cys Arg
             260                 265                 270        
 Glu Ser Ile Leu Asp Gly Leu Lys Arg Thr Thr Asp Met Met Phe Gly
         275                 280                 285            
 Gly Lys Gln Val Val Val Cys Gly Tyr Gly Glu Val Gly Lys Gly Cys
     290                 295                 300                
 Cys Ala Ala Leu Lys Ala Met Gly Ser Ile Val Tyr Val Thr Glu Ile
 305                 310                 315                 320
 Asp Pro Ile Cys Ala Leu Gln Ala Cys Met Asp Gly Phe Arg Leu Val
                 325                 330                 335    
 Lys Leu Asn Glu Val Ile Arg Gln Val Asp Ile Val Ile Thr Cys Thr
             340                 345                 350        
 Gly Asn Lys Asn Val Val Thr Arg Glu His Leu Asp Arg Met Lys Asn
         355                 360                 365            
 Ser Cys Ile Val Cys Asn Met Gly His Ser Asn Thr Glu Ile Asp Val
     370                 375                 380                
 Ala Ser Leu Arg Thr Pro Glu Leu Thr Trp Glu Arg Val Arg Ser Gln
 385                 390                 395                 400
 Val Asp His Val Ile Trp Pro Asp Gly Lys Arg Ile Val Leu Leu Ala
                 405                 410                 415    
 Glu Gly Arg Leu Leu Asn Leu Ser Cys Ser Thr Val Pro Thr Phe Val
             420                 425                 430        
 Leu Ser Ile Thr Ala Thr Thr Gln Ala Leu Ala Leu Ile Glu Leu Tyr
         435                 440                 445            
 Asn Ala Pro Glu Gly Arg Tyr Lys Gln Asp Val Tyr Leu Leu Pro Lys
     450                 455                 460                
 Lys Met Asp Glu Tyr Val Ala Ser Leu His Leu Pro Thr Phe Asp Ala
 465                 470                 475                 480
 His Leu Thr Glu Leu Thr Asp Glu Gln Ala Lys Tyr Leu Gly Leu Asn
                 485                 490                 495    
 Lys Asn Gly Pro Phe Lys Pro Asn Tyr Tyr Arg Tyr
             500                 505            



      <210> 876
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 876
 Met Gln Ser His Phe Leu Ser Ser Cys Leu Ser Ala Ser Ala Thr Gln
   1               5                  10                  15    
 Ile Ala Ser Gln Asn Phe Asp Pro Ala Thr Val Ser Val Ala Thr Ala
              20                  25                  30        
 His Lys Gly Ala Glu Pro Ser Arg Gly Thr Ala Trp Gly Pro Val Ala
          35                  40                  45            
 Lys Arg Leu Gln Gln Glu Leu Met Thr Leu Met Met Pro Gly Asp Lys
      50                  55                  60                
 Arg Ile Ser Ala Tyr Pro Glu Ser Leu Ile Lys Trp Thr Pro Ser Met
  65                  70                  75                  80
 Lys Gln Leu Ala Gln Cys Met Lys Ile
                  85                



      <210> 877
      <211> 834
      <212> PRT
      <213> Homo sapiens


      <400> 877
 Met Lys His Thr Leu Ala Leu Leu Ala Pro Leu Leu Gly Leu Gly Leu
   1               5                  10                  15    
 Gly Leu Ala Leu Ser Gln Leu Ala Ala Gly Ala Thr Asp Cys Lys Phe
              20                  25                  30        
 Leu Gly Pro Ala Glu His Leu Thr Phe Thr Pro Ala Ala Arg Ala Arg
          35                  40                  45            
 Trp Leu Ala Pro Arg Val Arg Ala Pro Gly Leu Leu Asp Ser Leu Tyr
      50                  55                  60                
 Gly Thr Val Arg Arg Phe Leu Ser Val Val Gln Leu Asn Pro Phe Pro
  65                  70                  75                  80
 Ser Glu Leu Val Lys Ala Leu Leu Asn Glu Leu Ala Ser Val Lys Val
                  85                  90                  95    
 Asn Glu Val Val Arg Tyr Glu Ala Gly Tyr Val Val Cys Ala Val Ile
             100                 105                 110        
 Ala Gly Leu Tyr Leu Leu Leu Val Pro Thr Ala Gly Leu Cys Phe Cys
         115                 120                 125            
 Cys Cys Arg Cys His Arg Arg Cys Gly Gly Arg Val Lys Thr Glu His
     130                 135                 140                
 Lys Ala Leu Ala Cys Glu Arg Ala Ala Leu Met Val Phe Leu Leu Leu
 145                 150                 155                 160
 Thr Thr Leu Leu Leu Leu Ile Gly Val Val Cys Ala Phe Val Thr Asn
                 165                 170                 175    
 Gln Arg Thr His Glu Gln Met Gly Pro Ser Ile Glu Ala Met Pro Glu
             180                 185                 190        
 Thr Leu Leu Ser Leu Trp Gly Leu Val Ser Asp Val Pro Gln Glu Leu
         195                 200                 205            
 Gln Ala Val Ala Gln Gln Phe Ser Leu Pro Gln Glu Gln Val Ser Glu
     210                 215                 220                
 Glu Leu Asp Gly Val Gly Val Ser Ile Gly Ser Ala Ile His Thr Gln
 225                 230                 235                 240
 Leu Arg Ser Ser Val Tyr Pro Leu Leu Ala Ala Val Gly Ser Leu Gly
                 245                 250                 255    
 Gln Val Leu Gln Val Ser Val His His Leu Gln Thr Leu Asn Ala Thr
             260                 265                 270        
 Val Val Glu Leu Gln Ala Gly Gln Gln Asp Leu Glu Pro Ala Ile Arg
         275                 280                 285            
 Glu His Arg Asp Arg Leu Leu Glu Leu Leu Gln Glu Ala Arg Cys Gln
     290                 295                 300                
 Gly Asp Cys Ala Gly Ala Leu Ser Trp Ala Arg Thr Leu Glu Leu Gly
 305                 310                 315                 320
 Ala Asp Phe Ser Gln Val Pro Ser Val Asp His Val Leu His Gln Leu
                 325                 330                 335    
 Lys Gly Val Pro Glu Ala Asn Phe Ser Ser Met Val Gln Glu Glu Asn
             340                 345                 350        
 Ser Thr Phe Asn Ala Leu Pro Ala Leu Ala Ala Met Gln Thr Ser Ser
         355                 360                 365            
 Val Val Gln Glu Leu Lys Lys Ala Val Ala Gln Gln Pro Glu Gly Val
     370                 375                 380                
 Arg Thr Leu Ala Glu Gly Phe Pro Gly Leu Glu Ala Ala Ser Arg Trp
 385                 390                 395                 400
 Ala Gln Ala Leu Gln Glu Val Glu Glu Ser Ser Arg Pro Tyr Leu Gln
                 405                 410                 415    
 Glu Val Gln Arg Tyr Glu Thr Tyr Arg Trp Ile Val Gly Cys Val Leu
             420                 425                 430        
 Cys Ser Val Val Leu Phe Val Val Leu Cys Asn Leu Leu Gly Leu Asn
         435                 440                 445            
 Leu Gly Ile Trp Gly Leu Ser Ala Arg Asp Asp Pro Ser His Pro Glu
     450                 455                 460                
 Ala Lys Gly Glu Ala Gly Ala Arg Phe Leu Met Ala Gly Val Gly Leu
 465                 470                 475                 480
 Ser Phe Leu Phe Ala Ala Pro Leu Ile Leu Leu Val Phe Ala Thr Phe
                 485                 490                 495    
 Leu Val Gly Gly Asn Val Gln Thr Leu Val Cys Gln Ser Trp Glu Asn
             500                 505                 510        
 Ser Glu Leu Phe Glu Phe Ala Asp Thr Pro Gly Asn Leu Pro Pro Ser
         515                 520                 525            
 Met Asn Leu Ser Gln Leu Leu Gly Leu Arg Lys Asn Ile Ser Ile His
     530                 535                 540                
 Gln Ala Tyr Gln Gln Cys Lys Glu Gly Ala Ala Leu Trp Thr Val Leu
 545                 550                 555                 560
 Gln Leu Asn Asp Ser Tyr Asp Leu Glu Glu His Leu Asp Ile Asn Gln
                 565                 570                 575    
 Tyr Thr Asn Lys Leu Arg Gln Glu Leu Gln Ser Leu Lys Val Asp Thr
             580                 585                 590        
 Gln Ser Leu Asp Leu Leu Ser Ser Ala Ala Arg Arg Asp Leu Glu Ala
         595                 600                 605            
 Leu Gln Ser Ser Gly Leu Gln Arg Ile His Tyr Pro Asp Phe Leu Val
     610                 615                 620                
 Gln Ile Gln Arg Pro Val Val Lys Thr Ser Met Glu Gln Leu Ala Gln
 625                 630                 635                 640
 Glu Leu Gln Gly Leu Ala Gln Ala Gln Asp Asn Ser Val Leu Gly Gln
                 645                 650                 655    
 Arg Leu Gln Glu Glu Ala Gln Gly Leu Arg Asn Leu His Gln Glu Lys
             660                 665                 670        
 Val Val Pro Gln Gln Ser Leu Val Ala Lys Leu Asn Leu Ser Val Arg
         675                 680                 685            
 Ala Leu Glu Ser Ser Ala Pro Asn Leu Gln Leu Glu Thr Ser Asp Val
     690                 695                 700                
 Leu Ala Asn Val Thr Tyr Leu Lys Gly Glu Leu Pro Ala Trp Ala Ala
 705                 710                 715                 720
 Arg Ile Leu Arg Asn Val Ser Glu Cys Phe Leu Ala Arg Glu Met Gly
                 725                 730                 735    
 Tyr Phe Ser Gln Tyr Val Ala Trp Val Arg Glu Glu Val Thr Gln Arg
             740                 745                 750        
 Ile Ala Thr Cys Gln Pro Leu Ser Gly Ala Leu Asp Asn Ser Arg Val
         755                 760                 765            
 Ile Leu Cys Asp Met Met Ala Asp Pro Trp Asn Ala Phe Trp Phe Cys
     770                 775                 780                
 Leu Ala Trp Cys Thr Phe Phe Leu Ile Pro Ser Ile Ile Phe Ala Val
 785                 790                 795                 800
 Lys Thr Ser Lys Tyr Phe Arg Pro Ile Arg Lys Arg Leu Ser Ser Thr
                 805                 810                 815    
 Ser Ser Glu Glu Thr Gln Leu Phe His Ile Pro Arg Val Thr Ser Leu
             820                 825                 830        
 Lys Leu
        



      <210> 878
      <211> 388
      <212> PRT
      <213> Homo sapiens


      <400> 878
 Met Met Ser Pro Ser Gln Ala Ser Leu Leu Phe Leu Asn Val Cys Ile
   1               5                  10                  15    
 Phe Ile Cys Gly Glu Ala Val Gln Gly Asn Cys Val His His Ser Thr
              20                  25                  30        
 Asp Ser Ser Val Val Asn Ile Val Glu Asp Gly Ser Asn Ala Lys Asp
          35                  40                  45            
 Glu Ser Lys Ser Asn Asp Thr Val Cys Lys Glu Asp Cys Glu Glu Ser
      50                  55                  60                
 Cys Asp Val Lys Thr Lys Ile Thr Arg Glu Glu Lys His Phe Met Cys
  65                  70                  75                  80
 Arg Asn Leu Gln Asn Ser Ile Val Ser Tyr Thr Arg Ser Thr Lys Lys
                  85                  90                  95    
 Leu Leu Arg Asn Met Met Asp Glu Gln Gln Ala Ser Leu Asp Tyr Leu
             100                 105                 110        
 Ser Asn Gln Val Asn Glu Leu Met Asn Arg Val Leu Leu Leu Thr Thr
         115                 120                 125            
 Glu Val Phe Arg Lys Gln Leu Asp Pro Phe Pro His Arg Pro Val Gln
     130                 135                 140                
 Ser His Gly Leu Asp Cys Thr Asp Ile Lys Asp Thr Ile Gly Ser Val
 145                 150                 155                 160
 Thr Lys Thr Pro Ser Gly Leu Tyr Ile Ile His Pro Glu Gly Ser Ser
                 165                 170                 175    
 Tyr Pro Phe Glu Val Met Cys Asp Met Asp Tyr Arg Gly Gly Gly Trp
             180                 185                 190        
 Thr Val Ile Gln Lys Arg Ile Asp Gly Ile Ile Asp Phe Gln Arg Leu
         195                 200                 205            
 Trp Cys Asp Tyr Leu Asp Gly Phe Gly Asp Leu Leu Gly Glu Phe Trp
     210                 215                 220                
 Leu Gly Leu Lys Lys Ile Phe Tyr Ile Val Asn Gln Lys Asn Thr Ser
 225                 230                 235                 240
 Phe Met Leu Tyr Val Ala Leu Glu Ser Glu Asp Asp Thr Leu Ala Tyr
                 245                 250                 255    
 Ala Ser Tyr Asp Asn Phe Trp Leu Glu Asp Glu Thr Arg Phe Phe Lys
             260                 265                 270        
 Met His Leu Gly Arg Tyr Ser Gly Asn Ala Gly Asp Ala Phe Arg Gly
         275                 280                 285            
 Leu Lys Lys Glu Asp Asn Gln Asn Ala Met Pro Phe Ser Thr Ser Asp
     290                 295                 300                
 Val Asp Asn Asp Gly Cys Arg Pro Ala Cys Leu Val Asn Gly Gln Ser
 305                 310                 315                 320
 Val Lys Ser Cys Ser His Leu His Asn Lys Thr Gly Trp Trp Phe Asn
                 325                 330                 335    
 Glu Cys Gly Leu Ala Asn Leu Asn Gly Ile His His Phe Ser Gly Lys
             340                 345                 350        
 Leu Leu Ala Thr Gly Ile Gln Trp Gly Thr Trp Thr Lys Asn Asn Ser
         355                 360                 365            
 Pro Val Lys Ile Lys Ser Val Ser Met Lys Ile Arg Arg Met Tyr Asn
     370                 375                 380                
 Pro Tyr Phe Lys
 385            



      <210> 879
      <211> 388
      <212> PRT
      <213> Homo sapiens


      <400> 879
 Met Met Ser Pro Ser Gln Ala Ser Leu Leu Phe Leu Asn Val Cys Ile
   1               5                  10                  15    
 Phe Ile Cys Gly Glu Val Val Gln Gly Asn Cys Val His His Ser Thr
              20                  25                  30        
 Asp Ser Ser Val Val Asn Ile Val Glu Asp Gly Ser Asn Ala Lys Asp
          35                  40                  45            
 Glu Ser Lys Ser Asn Asp Thr Val Cys Lys Glu Asp Cys Glu Glu Ser
      50                  55                  60                
 Cys Asp Val Lys Thr Lys Ile Thr Arg Glu Glu Lys His Phe Met Cys
  65                  70                  75                  80
 Arg Asn Leu Gln Asn Ser Ile Val Ser Tyr Thr Arg Ser Thr Lys Lys
                  85                  90                  95    
 Leu Leu Arg Asn Met Met Asp Glu Gln Gln Ala Ser Leu Asp Tyr Leu
             100                 105                 110        
 Ser Asn Gln Val Asn Glu Leu Met Asn Arg Val Leu Leu Leu Thr Thr
         115                 120                 125            
 Glu Val Phe Arg Lys Gln Leu Asp Pro Phe Pro His Arg Pro Val Gln
     130                 135                 140                
 Ser His Gly Leu Asp Cys Thr Asp Ile Lys Asp Thr Ile Gly Ser Val
 145                 150                 155                 160
 Thr Lys Thr Pro Ser Gly Leu Tyr Ile Ile His Pro Glu Gly Ser Ser
                 165                 170                 175    
 Tyr Pro Phe Glu Val Met Cys Asp Met Asp Tyr Arg Gly Gly Gly Trp
             180                 185                 190        
 Thr Val Ile Gln Lys Arg Ile Asp Gly Ile Ile Asp Phe Gln Arg Leu
         195                 200                 205            
 Trp Cys Asp Tyr Leu Asp Gly Phe Gly Asp Leu Leu Gly Glu Phe Trp
     210                 215                 220                
 Leu Gly Leu Lys Lys Ile Phe Tyr Ile Val Asn Gln Lys Asn Thr Ser
 225                 230                 235                 240
 Phe Met Leu Tyr Val Ala Leu Glu Ser Glu Asp Asp Thr Leu Ala Tyr
                 245                 250                 255    
 Ala Ser Tyr Asp Asn Phe Trp Leu Glu Asp Glu Thr Arg Phe Phe Lys
             260                 265                 270        
 Met His Leu Gly Arg Tyr Ser Gly Asn Ala Gly Asp Ala Phe Arg Gly
         275                 280                 285            
 Leu Lys Lys Glu Asp Asn Gln Asn Ala Met Pro Phe Ser Thr Ser Asp
     290                 295                 300                
 Val Asp Asn Asp Gly Cys Arg Pro Ala Cys Leu Val Asn Gly Gln Ser
 305                 310                 315                 320
 Val Lys Ser Cys Ser His Leu His Asn Lys Thr Gly Trp Trp Phe Asn
                 325                 330                 335    
 Glu Cys Gly Leu Ala Asn Leu Asn Gly Ile His His Phe Ser Gly Lys
             340                 345                 350        
 Leu Leu Ala Thr Gly Ile Gln Trp Gly Thr Trp Thr Lys Asn Asn Ser
         355                 360                 365            
 Pro Val Lys Ile Lys Ser Val Ser Met Lys Ile Arg Arg Met Tyr Asn
     370                 375                 380                
 Pro Tyr Phe Lys
 385            



      <210> 880
      <211> 388
      <212> PRT
      <213> Homo sapiens


      <400> 880
 Met Met Ser Pro Ser Gln Ala Ser Leu Leu Phe Leu Asn Val Cys Ile
   1               5                  10                  15    
 Phe Ile Cys Gly Glu Val Val Gln Gly Asn Cys Val His His Ser Thr
              20                  25                  30        
 Asp Ser Ser Val Val Asn Ile Val Glu Asp Gly Ser Asn Ala Lys Asp
          35                  40                  45            
 Glu Ser Lys Ser Asn Asp Thr Val Cys Lys Glu Asp Cys Glu Glu Ser
      50                  55                  60                
 Cys Asp Val Lys Thr Lys Ile Thr Arg Glu Glu Lys His Phe Met Cys
  65                  70                  75                  80
 Arg Asn Leu Gln Asn Ser Ile Val Ser Tyr Thr Arg Ser Thr Lys Lys
                  85                  90                  95    
 Leu Leu Arg Asn Met Met Asp Glu Gln Gln Ala Ser Leu Asp Tyr Leu
             100                 105                 110        
 Ser Asn Gln Val Asn Glu Leu Met Asn Arg Val Leu Leu Leu Thr Thr
         115                 120                 125            
 Glu Val Phe Arg Lys Gln Leu Asp Pro Phe Pro His Arg Pro Val Gln
     130                 135                 140                
 Ser His Gly Leu Asp Cys Thr Asp Ile Lys Asp Thr Ile Gly Ser Val
 145                 150                 155                 160
 Thr Lys Thr Pro Ser Gly Leu Tyr Ile Ile His Pro Glu Gly Ser Ser
                 165                 170                 175    
 Tyr Pro Phe Glu Val Met Cys Asp Met Asp Tyr Arg Gly Gly Gly Trp
             180                 185                 190        
 Thr Val Ile Gln Lys Arg Ile Asp Gly Ile Ile Asp Phe Gln Arg Leu
         195                 200                 205            
 Trp Cys Asp Tyr Leu Asp Gly Phe Gly Asp Leu Leu Gly Glu Phe Trp
     210                 215                 220                
 Leu Gly Leu Lys Lys Ile Phe Tyr Ile Val Asn Gln Lys Asn Thr Ser
 225                 230                 235                 240
 Phe Met Leu Tyr Val Ala Leu Glu Ser Glu Asp Asp Thr Leu Ala Tyr
                 245                 250                 255    
 Ala Ser Tyr Asp Asn Phe Trp Leu Glu Asp Glu Thr Arg Phe Phe Lys
             260                 265                 270        
 Met His Leu Gly Arg Tyr Ser Gly Asn Ala Gly Asp Ala Phe Arg Gly
         275                 280                 285            
 Leu Lys Lys Glu Asp Asn Gln Asn Ala Met Pro Phe Ser Thr Ser Asp
     290                 295                 300                
 Val Asp Asn Asp Gly Cys Arg Pro Ala Cys Leu Val Asn Gly Gln Ser
 305                 310                 315                 320
 Val Lys Ser Cys Ser His Leu His Asn Lys Thr Gly Trp Trp Phe Asn
                 325                 330                 335    
 Glu Cys Gly Leu Ala Asn Leu Asn Gly Ile His His Phe Ser Gly Lys
             340                 345                 350        
 Leu Leu Ala Thr Gly Ile Gln Trp Gly Thr Trp Thr Lys Asn Asn Ser
         355                 360                 365            
 Pro Val Lys Ile Lys Ser Val Ser Met Lys Ile Arg Arg Met Tyr Asn
     370                 375                 380                
 Pro Tyr Phe Lys
 385            



      <210> 881
      <211> 114
      <212> PRT
      <213> Homo sapiens


      <400> 881
 Met His Ile Pro Gly Val Tyr Pro Asn Gln Trp Asn Thr Asn Phe Tyr
   1               5                  10                  15    
 Leu Phe Ile Tyr Phe Glu Ala Glu Ser His Ser Val Ala Gln Thr Gly
              20                  25                  30        
 Leu Gln Trp Arg His Leu Gly Ser Leu Gln Leu Pro Pro Pro Arg Phe
          35                  40                  45            
 Lys Arg Phe Ser Cys Leu Ser Leu Pro Ser Arg Trp Asp Tyr Arg His
      50                  55                  60                
 Thr Pro Ser Cys Pro Ala Asn Phe Phe Val Leu Leu Val Glu Thr Gly
  65                  70                  75                  80
 Phe His His Val Asp Gln Ala Gly Leu Asp Leu Leu Thr Ser Ser Asp
                  85                  90                  95    
 Ser Pro Ala Leu Ala Ser Lys Ser Ala Arg Ile Thr Gly Val Ser His
             100                 105                 110        
 His Ala
        



      <210> 882
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 882
 Met Ser Arg Asn Leu Arg Thr Ala Leu Ile Phe Gly Gly Phe Ile Ser
   1               5                  10                  15    
 Leu Ile Gly Ala Ala Phe Tyr Pro Ile Tyr Phe Arg Pro Leu Met Arg
              20                  25                  30        
 Leu Glu Glu Tyr Lys Lys Glu Gln Ala Ile Asn Arg Ala Gly Ile Val
          35                  40                  45            
 Gln Glu Asp Val Gln Pro Pro Gly Leu Lys Val Trp Ser Asp Pro Phe
      50                  55                  60                
 Gly Arg Lys
  65        



      <210> 883
      <211> 501
      <212> PRT
      <213> Homo sapiens


      <400> 883
 Met Val Arg Lys Pro Val Val Ser Thr Ile Ser Lys Gly Gly Tyr Leu
   1               5                  10                  15    
 Gln Gly Asn Val Asn Gly Arg Leu Pro Ser Leu Gly Asn Lys Glu Pro
              20                  25                  30        
 Pro Gly Gln Glu Lys Val Gln Leu Lys Arg Lys Val Thr Leu Leu Arg
          35                  40                  45            
 Gly Val Ser Ile Ile Ile Gly Thr Ile Ile Gly Ala Gly Ile Phe Ile
      50                  55                  60                
 Ser Pro Lys Gly Val Leu Gln Asn Thr Gly Ser Val Gly Met Ser Leu
  65                  70                  75                  80
 Thr Ile Trp Thr Val Cys Gly Val Leu Ser Leu Phe Gly Ala Leu Ser
                  85                  90                  95    
 Tyr Ala Glu Leu Gly Thr Thr Ile Lys Lys Ser Gly Gly His Tyr Thr
             100                 105                 110        
 Tyr Ile Leu Glu Val Phe Gly Pro Leu Pro Ala Phe Val Arg Val Trp
         115                 120                 125            
 Val Glu Leu Leu Ile Ile Arg Pro Ala Ala Thr Ala Val Ile Ser Leu
     130                 135                 140                
 Ala Phe Gly Arg Tyr Ile Leu Glu Pro Phe Phe Ile Gln Cys Glu Ile
 145                 150                 155                 160
 Pro Glu Leu Ala Ile Lys Leu Ile Thr Ala Val Gly Ile Thr Val Val
                 165                 170                 175    
 Met Val Leu Asn Ser Met Ser Val Ser Trp Ser Ala Arg Ile Gln Ile
             180                 185                 190        
 Phe Leu Thr Phe Cys Lys Leu Thr Ala Ile Leu Ile Ile Ile Val Pro
         195                 200                 205            
 Gly Val Met Gln Leu Ile Lys Gly Gln Thr Gln Asn Phe Lys Asp Ala
     210                 215                 220                
 Phe Ser Gly Arg Asp Ser Ser Ile Thr Arg Leu Pro Leu Ala Phe Tyr
 225                 230                 235                 240
 Tyr Gly Met Tyr Ala Tyr Ala Gly Trp Phe Tyr Leu Asn Phe Val Thr
                 245                 250                 255    
 Glu Glu Val Glu Asn Pro Glu Lys Thr Ile Pro Leu Ala Ile Cys Ile
             260                 265                 270        
 Ser Met Ala Ile Val Thr Ile Gly Tyr Val Leu Thr Asn Val Ala Tyr
         275                 280                 285            
 Phe Thr Thr Ile Asn Ala Glu Glu Leu Leu Leu Ser Asn Ala Val Ala
     290                 295                 300                
 Val Thr Phe Ser Glu Arg Leu Leu Gly Asn Phe Ser Leu Ala Val Pro
 305                 310                 315                 320
 Ile Phe Val Ala Leu Ser Cys Phe Gly Ser Met Asn Gly Gly Val Phe
                 325                 330                 335    
 Ala Val Ser Arg Leu Phe Tyr Val Ala Ser Arg Glu Gly His Leu Pro
             340                 345                 350        
 Glu Ile Leu Ser Met Ile His Val Arg Lys His Thr Pro Leu Pro Ala
         355                 360                 365            
 Val Ile Val Leu His Pro Leu Thr Met Ile Met Leu Phe Ser Gly Asp
     370                 375                 380                
 Leu Asp Ser Leu Leu Asn Phe Leu Ser Phe Ala Arg Trp Leu Phe Ile
 385                 390                 395                 400
 Gly Leu Ala Val Ala Gly Leu Ile Tyr Leu Arg Tyr Lys Cys Pro Asp
                 405                 410                 415    
 Met His Arg Pro Phe Lys Val Pro Leu Phe Ile Pro Ala Leu Phe Ser
             420                 425                 430        
 Phe Thr Cys Leu Phe Met Val Ala Leu Ser Leu Tyr Ser Asp Pro Phe
         435                 440                 445            
 Ser Thr Gly Ile Gly Phe Val Ile Thr Leu Thr Gly Val Pro Ala Tyr
     450                 455                 460                
 Tyr Leu Phe Ile Ile Trp Asp Lys Lys Pro Arg Trp Phe Arg Ile Met
 465                 470                 475                 480
 Ser Glu Lys Ile Thr Arg Thr Leu Gln Ile Ile Leu Glu Val Val Pro
                 485                 490                 495    
 Glu Glu Asp Lys Leu
             500    



      <210> 884
      <211> 661
      <212> PRT
      <213> Homo sapiens


      <400> 884
 Met Val Glu Gly Glu Gly Glu Ala Gly Thr Phe Phe Thr Arg Trp Gln
   1               5                  10                  15    
 Glu Gly Met Ser Ala Arg Thr Arg Lys Cys His Thr Leu Lys Pro Ser
              20                  25                  30        
 Ala Leu Val Arg Thr His Lys Leu Ser Glu Gln Arg Gly Ser Glu Thr
          35                  40                  45            
 Gln His Arg Gly Ser Ala Pro His Ser Glu Ser Asp Leu Pro Glu Gln
      50                  55                  60                
 Glu Glu Glu Ile Leu Gly Ser Asp Asp Asp Glu Gln Glu Asp Pro Asn
  65                  70                  75                  80
 Asp Tyr Cys Lys Gly Gly Tyr His Leu Val Lys Ile Gly Asp Leu Phe
                  85                  90                  95    
 Asn Gly Arg Tyr His Val Ile Arg Lys Leu Gly Trp Gly His Phe Ser
             100                 105                 110        
 Thr Val Trp Leu Ser Trp Asp Ile Gln Gly Lys Lys Phe Val Ala Met
         115                 120                 125            
 Lys Val Val Lys Ser Ala Glu His Tyr Thr Glu Thr Ala Leu Asp Glu
     130                 135                 140                
 Ile Arg Leu Leu Lys Ser Val Leu Gln Gly Leu Asp Tyr Leu His Thr
 145                 150                 155                 160
 Lys Cys Arg Ile Ile His Thr Asp Ile Lys Pro Glu Asn Ile Leu Leu
                 165                 170                 175    
 Ser Val Asn Glu Gln Tyr Ile Arg Arg Leu Ala Ala Glu Ala Thr Glu
             180                 185                 190        
 Trp Gln Arg Ser Gly Ala Pro Pro Pro Ser Gly Ser Ala Val Ser Thr
         195                 200                 205            
 Ala Pro Gln Pro Lys Pro Ala Asp Lys Met Ser Lys Asn Lys Lys Lys
     210                 215                 220                
 Lys Leu Lys Lys Lys Gln Lys Arg Gln Ala Glu Leu Leu Glu Lys Arg
 225                 230                 235                 240
 Met Gln Glu Ile Glu Glu Met Glu Lys Glu Ser Gly Pro Gly Gln Lys
                 245                 250                 255    
 Arg Pro Asn Lys Gln Glu Glu Ser Glu Ser Pro Val Glu Arg Pro Leu
             260                 265                 270        
 Lys Glu Asn Pro Pro Asn Lys Met Thr Gln Glu Lys Leu Glu Glu Ser
         275                 280                 285            
 Ser Thr Ile Gly Gln Asp Gln Thr Leu Met Glu Arg Asp Thr Glu Gly
     290                 295                 300                
 Gly Ala Ala Glu Ile Asn Cys Asn Gly Val Ile Glu Val Ile Asn Tyr
 305                 310                 315                 320
 Thr Gln Asn Ser Asn Asn Glu Thr Leu Arg His Lys Glu Asp Leu His
                 325                 330                 335    
 Asn Ala Asn Asp Cys Asp Val Gln Asn Leu Asn Gln Glu Ser Ser Phe
             340                 345                 350        
 Leu Ser Ser Gln Asn Gly Asp Ser Ser Thr Ser Gln Glu Thr Asp Ser
         355                 360                 365            
 Cys Thr Pro Ile Thr Ser Glu Val Ser Asp Thr Met Val Cys Gln Ser
     370                 375                 380                
 Ser Ser Thr Val Gly Gln Ser Phe Ser Glu Gln His Ile Ser Gln Leu
 385                 390                 395                 400
 Gln Glu Ser Ile Arg Ala Glu Ile Pro Cys Glu Asp Glu Gln Glu Gln
                 405                 410                 415    
 Glu His Asn Gly Pro Leu Asp Asn Lys Gly Lys Ser Thr Ala Gly Asn
             420                 425                 430        
 Phe Leu Val Asn Pro Leu Glu Pro Lys Asn Ala Glu Lys Leu Lys Val
         435                 440                 445            
 Lys Ile Ala Asp Leu Gly Asn Ala Cys Trp Val His Lys His Phe Thr
     450                 455                 460                
 Glu Asp Ile Gln Thr Arg Gln Tyr Arg Ser Leu Glu Val Leu Ile Gly
 465                 470                 475                 480
 Ser Gly Tyr Asn Thr Pro Ala Asp Ile Trp Ser Thr Ala Cys Met Ser
                 485                 490                 495    
 Thr Lys His Gln Asp Trp Leu Leu Asn Tyr Val Thr Ser Pro Tyr Leu
             500                 505                 510        
 Arg Arg Ala Ala Phe Glu Leu Ala Thr Gly Asp Tyr Leu Phe Glu Pro
         515                 520                 525            
 His Ser Gly Glu Glu Tyr Thr Arg Asp Glu Asp His Ile Val His Ile
     530                 535                 540                
 Ile Glu Leu Ile Gly Arg Ile Pro Arg Arg Phe Ser Leu Ser Gly Lys
 545                 550                 555                 560
 Tyr Ser Gln Asp Phe Phe Ser His Arg Asp His Ile Ala Leu Ile Ile
                 565                 570                 575    
 Glu Leu Leu Gly Lys Val Pro Arg Lys Leu Ile Val Ala Gly Lys Tyr
             580                 585                 590        
 Ser Lys Glu Phe Phe Thr Lys Lys Gly Asp Leu Lys His Ile Thr Lys
         595                 600                 605            
 Leu Lys Pro Trp Gly Leu Phe Glu Val Leu Val Glu Lys Tyr Glu Trp
     610                 615                 620                
 Ser Gln Glu Glu Ala Ala Gly Phe Thr Asp Phe Leu Leu Pro Met Leu
 625                 630                 635                 640
 Glu Leu Ile Pro Glu Lys Arg Ala Thr Ala Ala Glu Cys Leu Arg His
                 645                 650                 655    
 Pro Trp Leu Asn Ser
             660    



      <210> 885
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 885
 Met Ile Asn Pro Glu Leu Arg Asp Gly Arg Ala Asp Gly Phe Ile His
   1               5                  10                  15    
 Arg Ile Ala Thr Trp Ser Lys His Ala Lys Pro Val Ala Cys Ser Gly
              20                  25                  30        
 Asp Trp Leu Gly Val Arg Asp Lys Cys Phe Tyr Phe Ser Asp Asp Thr
          35                  40                  45            
 Arg Asn Trp Thr Ala Ser Lys Ile Phe Cys Ser Leu Gln Lys Ala Glu
      50                  55                  60                
 Leu Ala Gln Ile Asp Thr Gln Glu Asp Met Glu Phe Leu Lys Arg Tyr
  65                  70                  75                  80
 Ala Gly Thr Asp Met His Trp Ile Gly Leu Ser Arg Lys Gln Gly Asp
                  85                  90                  95    
 Ser Trp Lys Trp Thr Asn Gly Thr Thr Phe Asn Gly His Gln Thr Pro
             100                 105                 110        
 Asn Gly Leu Ala Thr Gly Ala Ser Asp Asn Gly Phe Phe Cys Trp Asp
         115                 120                 125            
 Pro Leu Asp Arg Pro Leu Arg Glu Leu
     130                 135        



      <210> 886
      <211> 1463
      <212> PRT
      <213> Homo sapiens


      <400> 886
 Met Lys Asp Ile Glu Lys Leu Arg Leu Leu Met Asn Ser Cys Ser Glu
   1               5                  10                  15    
 Asp Lys Tyr Val Thr Ser Ala Tyr Gln Trp Met Val Pro Phe Leu His
              20                  25                  30        
 Arg Cys Glu Lys Gln Ser Pro Gly Val Ala Asn Glu Leu Leu Lys Glu
          35                  40                  45            
 Tyr Leu Val Thr Leu Ala Lys Gly Asp Leu Lys Phe Pro Leu Lys Ile
      50                  55                  60                
 Phe Gln His Ser Lys Pro Asp Leu Gln Gln Lys Ile Ile Pro Asp Gln
  65                  70                  75                  80
 Asp Gln Leu Met Ala Ile Ala Leu Glu Cys Ile Tyr Thr Cys Glu Arg
                  85                  90                  95    
 Asn Asp Gln Leu Cys Leu Cys Tyr Asp Leu Leu Glu Cys Leu Pro Glu
             100                 105                 110        
 Arg Gly Tyr Gly Asp Lys Thr Glu Ala Thr Thr Lys Leu His Asp Met
         115                 120                 125            
 Val Asp Gln Leu Glu Gln Ile Leu Ser Val Ser Glu Leu Leu Glu Lys
     130                 135                 140                
 His Gly Leu Glu Lys Pro Ile Ser Phe Val Lys Asn Thr Gln Ser Ser
 145                 150                 155                 160
 Ser Glu Glu Ala Arg Lys Leu Met Val Arg Leu Thr Arg His Thr Gly
                 165                 170                 175    
 Arg Lys Gln Pro Pro Val Ser Glu Ser His Trp Arg Thr Leu Leu Gln
             180                 185                 190        
 Asp Met Leu Thr Met Gln Gln Asn Val Tyr Thr Cys Leu Asp Ser Asp
         195                 200                 205            
 Ala Cys Tyr Glu Ile Phe Thr Glu Ser Leu Leu Cys Ser Ser Arg Leu
     210                 215                 220                
 Glu Asn Ile His Leu Ala Gly Gln Met Met His Cys Ser Ala Cys Ser
 225                 230                 235                 240
 Glu Asn Pro Pro Ala Gly Ile Ala His Lys Gly Lys Pro His Tyr Arg
                 245                 250                 255    
 Val Ser Tyr Glu Lys Ser Ile Asp Leu Val Leu Ala Ala Ser Arg Glu
             260                 265                 270        
 Tyr Phe Asn Ser Ser Thr Asn Leu Thr Asp Ser Cys Met Asp Leu Ala
         275                 280                 285            
 Arg Cys Cys Leu Gln Leu Ile Thr Asp Arg Pro Pro Ala Ile Gln Glu
     290                 295                 300                
 Glu Leu Asp Leu Ile Gln Ala Val Gly Cys Leu Glu Glu Phe Gly Val
 305                 310                 315                 320
 Lys Ile Leu Pro Leu Gln Val Arg Leu Cys Pro Asp Arg Ile Ser Leu
                 325                 330                 335    
 Ile Lys Glu Cys Ile Ser Gln Ser Pro Thr Cys Tyr Lys Gln Ser Thr
             340                 345                 350        
 Lys Leu Leu Gly Leu Ala Glu Leu Leu Arg Val Ala Gly Glu Asn Pro
         355                 360                 365            
 Glu Glu Arg Arg Gly Gln Val Leu Ile Leu Leu Val Glu Gln Ala Leu
     370                 375                 380                
 Arg Phe His Asp Tyr Lys Ala Ala Ser Met His Cys Gln Glu Leu Met
 385                 390                 395                 400
 Ala Thr Gly Tyr Pro Lys Ser Trp Asp Val Cys Ser Gln Leu Gly Gln
                 405                 410                 415    
 Ser Glu Gly Tyr Gln Asp Leu Ala Thr Arg Gln Glu Leu Met Ala Phe
             420                 425                 430        
 Ala Leu Thr His Cys Pro Pro Ser Ser Ile Glu Leu Leu Leu Ala Ala
         435                 440                 445            
 Ser Ser Ser Leu Gln Thr Glu Ile Leu Tyr Gln Arg Val Asn Phe Gln
     450                 455                 460                
 Ile His His Glu Gly Gly Glu Asn Ile Ser Ala Ser Pro Leu Thr Ser
 465                 470                 475                 480
 Lys Ala Val Gln Glu Asp Glu Val Gly Val Pro Gly Ser Asn Ser Ala
                 485                 490                 495    
 Asp Leu Leu Arg Trp Thr Thr Ala Thr Thr Met Lys Val Leu Ser Asn
             500                 505                 510        
 Thr Thr Thr Thr Thr Lys Ala Val Leu Gln Ala Val Ser Asp Gly Gln
         515                 520                 525            
 Trp Trp Lys Lys Ser Leu Thr Tyr Leu Arg Pro Leu Gln Gly Gln Lys
     530                 535                 540                
 Cys Gly Gly Ala Tyr Gln Ile Gly Thr Thr Ala Asn Glu Asp Leu Glu
 545                 550                 555                 560
 Lys Gln Gly Cys His Pro Phe Tyr Glu Ser Val Ile Ser Asn Pro Phe
                 565                 570                 575    
 Val Ala Glu Ser Glu Gly Thr Tyr Asp Thr Tyr Gln His Val Pro Val
             580                 585                 590        
 Glu Ser Phe Ala Glu Val Leu Leu Arg Thr Gly Lys Leu Ala Glu Ala
         595                 600                 605            
 Lys Asn Lys Gly Glu Val Phe Pro Thr Thr Glu Val Leu Leu Gln Leu
     610                 615                 620                
 Ala Ser Glu Ala Leu Pro Asn Asp Met Thr Leu Ala Leu Ala Tyr Leu
 625                 630                 635                 640
 Leu Ala Leu Pro Gln Val Leu Asp Ala Asn Arg Cys Phe Glu Lys Gln
                 645                 650                 655    
 Ser Pro Ser Ala Leu Ser Leu Gln Leu Ala Ala Tyr Tyr Tyr Ser Leu
             660                 665                 670        
 Gln Ile Tyr Ala Arg Leu Ala Pro Cys Phe Arg Asp Lys Cys His Pro
         675                 680                 685            
 Leu Tyr Arg Ala Asp Pro Lys Glu Leu Ile Lys Met Val Thr Arg His
     690                 695                 700                
 Val Thr Arg His Glu His Glu Ala Trp Pro Glu Asp Leu Ile Ser Leu
 705                 710                 715                 720
 Thr Lys Gln Leu His Cys Tyr Asn Glu Arg Leu Leu Asp Phe Thr Gln
                 725                 730                 735    
 Ala Gln Ile Leu Gln Gly Leu Arg Lys Gly Val Asp Val Gln Arg Phe
             740                 745                 750        
 Thr Ala Asp Asp Gln Tyr Lys Arg Glu Thr Ile Leu Gly Leu Ala Glu
         755                 760                 765            
 Thr Leu Glu Glu Ser Val Tyr Ser Ile Ala Ile Ser Leu Ala Gln Arg
     770                 775                 780                
 Tyr Ser Val Ser Arg Trp Glu Val Phe Met Thr His Leu Glu Phe Leu
 785                 790                 795                 800
 Phe Thr Asp Ser Gly Leu Ser Thr Leu Glu Ile Glu Asn Arg Ala Gln
                 805                 810                 815    
 Asp Leu His Leu Phe Glu Thr Leu Lys Thr Asp Pro Glu Ala Phe His
             820                 825                 830        
 Gln His Met Val Lys Tyr Ile Tyr Pro Thr Ile Gly Gly Phe Asp His
         835                 840                 845            
 Glu Arg Leu Gln Tyr Tyr Phe Thr Leu Leu Glu Asn Cys Gly Cys Ala
     850                 855                 860                
 Asp Leu Gly Asn Cys Ala Ile Lys Pro Glu Thr His Ile Arg Leu Leu
 865                 870                 875                 880
 Lys Lys Phe Lys Val Val Ala Ser Gly Leu Asn Tyr Lys Lys Leu Thr
                 885                 890                 895    
 Asp Glu Asn Met Ser Pro Leu Glu Ala Leu Glu Pro Val Leu Ser Ser
             900                 905                 910        
 Gln Asn Ile Leu Ser Ile Ser Lys Leu Val Pro Lys Ile Pro Glu Lys
         915                 920                 925            
 Asp Gly Gln Met Leu Ser Pro Ser Ser Leu Tyr Thr Ile Trp Leu Gln
     930                 935                 940                
 Lys Leu Phe Trp Thr Gly Asp Pro His Leu Ile Lys Gln Val Pro Gly
 945                 950                 955                 960
 Ser Ser Pro Glu Trp Leu His Ala Tyr Asp Val Cys Met Lys Tyr Phe
                 965                 970                 975    
 Asp Arg Leu His Pro Gly Asp Leu Ile Thr Val Val Asp Ala Val Thr
             980                 985                 990        
 Phe Ser Pro Lys Ala Val Thr Lys Leu Ser Val Glu Ala Arg Lys Glu
         995                1000                1005            
 Met Thr Arg Lys Ala Ile Lys Thr Val Lys His Phe Ile Glu Lys Pro
    1010                1015                1020                
 Arg Lys Arg Asn Ser Glu Asp Glu Ala Gln Glu Ala Lys Asp Ser Lys
1025                1030                1035                1040
 Val Thr Tyr Ala Asp Thr Leu Asn His Leu Glu Lys Ser Leu Ala His
                1045                1050                1055    
 Leu Glu Thr Leu Ser His Ser Phe Ile Leu Ser Leu Lys Asn Ser Glu
            1060                1065                1070        
 Gln Glu Thr Leu Gln Lys Tyr Ser His Leu Tyr Asp Leu Ser Arg Ser
        1075                1080                1085            
 Glu Lys Glu Lys Leu His Asp Glu Ala Val Ala Ile Cys Leu Asp Gly
    1090                1095                1100                
 Gln Pro Leu Ala Met Ile Gln Gln Leu Leu Glu Val Ala Val Gly Pro
1105                1110                1115                1120
 Leu Asp Ile Ser Pro Lys Asp Ile Val Gln Ser Ala Ile Met Lys Ile
                1125                1130                1135    
 Ile Ser Ala Leu Ser Gly Gly Ser Ala Asp Leu Gly Gly Pro Arg Asp
            1140                1145                1150        
 Pro Leu Lys Val Leu Glu Gly Val Val Ala Ala Val His Ala Ser Val
        1155                1160                1165            
 Asp Lys Gly Glu Glu Leu Val Ser Pro Glu Asp Leu Leu Glu Trp Leu
    1170                1175                1180                
 Arg Pro Phe Cys Ala Asp Asp Ala Trp Pro Val Arg Pro Arg Ile His
1185                1190                1195                1200
 Val Leu Gln Ile Leu Gly Gln Ser Phe His Leu Thr Glu Glu Asp Ser
                1205                1210                1215    
 Lys Leu Leu Val Phe Phe Arg Thr Glu Ala Ile Leu Lys Ala Ser Trp
            1220                1225                1230        
 Pro Gln Arg Gln Val Asp Ile Ala Asp Ile Glu Asn Glu Glu Asn Arg
        1235                1240                1245            
 Tyr Cys Leu Phe Met Glu Leu Leu Glu Ser Ser His His Glu Ala Glu
    1250                1255                1260                
 Phe Gln His Leu Val Leu Leu Leu Gln Ala Trp Pro Pro Met Lys Ser
1265                1270                1275                1280
 Glu Tyr Val Ile Thr Asn Asn Pro Trp Val Arg Leu Ala Thr Val Met
                1285                1290                1295    
 Leu Thr Arg Cys Thr Met Glu Asn Lys Glu Gly Leu Gly Asn Glu Val
            1300                1305                1310        
 Leu Lys Met Cys Arg Ser Leu Tyr Asn Thr Lys Gln Met Leu Pro Ala
        1315                1320                1325            
 Glu Gly Val Lys Glu Leu Cys Leu Leu Leu Leu Asn Gln Ser Leu Leu
    1330                1335                1340                
 Leu Pro Ser Leu Lys Leu Leu Leu Glu Ser Arg Asp Glu His Leu His
1345                1350                1355                1360
 Glu Met Ala Leu Glu Gln Ile Thr Ala Val Thr Thr Val Asn Asp Ser
                1365                1370                1375    
 Asn Cys Asp Gln Glu Leu Leu Ser Leu Leu Leu Asp Ala Lys Leu Leu
            1380                1385                1390        
 Val Lys Cys Val Ser Thr Pro Phe Tyr Pro Arg Ile Val Asp His Leu
        1395                1400                1405            
 Leu Ala Ser Leu Gln Gln Gly Arg Trp Asp Ala Glu Glu Leu Gly Arg
    1410                1415                1420                
 His Leu Arg Glu Ala Gly His Glu Ala Glu Ala Gly Ser Leu Leu Leu
1425                1430                1435                1440
 Ala Val Arg Gly Thr His Gln Ala Phe Arg Thr Phe Ser Thr Ala Leu
                1445                1450                1455    
 Arg Ala Ala Gln His Trp Val
            1460            



      <210> 887
      <211> 1420
      <212> PRT
      <213> Homo sapiens


      <400> 887
 Met Lys Asp Ile Glu Lys Leu Arg Leu Leu Met Asn Ser Cys Ser Glu
   1               5                  10                  15    
 Asp Lys Tyr Val Thr Ser Ala Tyr Gln Trp Met Val Pro Phe Leu His
              20                  25                  30        
 Arg Cys Glu Lys Gln Ser Pro Gly Val Ala Asn Glu Leu Leu Lys Glu
          35                  40                  45            
 Tyr Leu Val Thr Leu Ala Lys Gly Asp Leu Lys Phe Pro Leu Lys Ile
      50                  55                  60                
 Phe Gln His Ser Lys Pro Asp Leu Gln Gln Lys Ile Ile Pro Asp Gln
  65                  70                  75                  80
 Asp Gln Leu Met Ala Ile Ala Leu Glu Cys Ile Tyr Thr Cys Glu Arg
                  85                  90                  95    
 Asn Asp Gln Leu Cys Leu Cys Tyr Asp Leu Leu Glu Cys Leu Pro Glu
             100                 105                 110        
 Arg Gly Tyr Gly Asp Lys Thr Glu Ala Thr Thr Lys Leu His Asp Met
         115                 120                 125            
 Val Asp Gln Leu Glu Gln Ile Leu Ser Val Ser Glu Leu Leu Glu Lys
     130                 135                 140                
 His Gly Leu Glu Lys Pro Ile Ser Phe Val Lys Asn Thr Gln Ser Ser
 145                 150                 155                 160
 Ser Glu Glu Ala Arg Lys Leu Met Val Arg Leu Thr Arg His Thr Gly
                 165                 170                 175    
 Arg Lys Gln Pro Pro Val Ser Glu Ser His Trp Arg Thr Leu Leu Gln
             180                 185                 190        
 Asp Met Leu Thr Met Gln Gln Asn Val Tyr Thr Cys Leu Asp Ser Asp
         195                 200                 205            
 Ala Cys Tyr Glu Ile Phe Thr Glu Ser Leu Leu Cys Ser Ser Arg Leu
     210                 215                 220                
 Glu Asn Ile His Leu Ala Gly Gln Met Met His Cys Ser Ala Cys Ser
 225                 230                 235                 240
 Glu Asn Pro Pro Ala Gly Ile Ala His Lys Gly Lys Pro His Tyr Arg
                 245                 250                 255    
 Val Ser Tyr Glu Lys Ser Ile Asp Leu Val Leu Ala Ala Ser Arg Glu
             260                 265                 270        
 Tyr Phe Asn Ser Ser Thr Asn Leu Thr Asp Ser Cys Met Asp Leu Ala
         275                 280                 285            
 Arg Cys Cys Leu Gln Leu Ile Thr Asp Arg Pro Pro Ala Ile Gln Glu
     290                 295                 300                
 Glu Leu Asp Leu Ile Gln Ala Val Gly Cys Leu Glu Glu Phe Gly Val
 305                 310                 315                 320
 Lys Ile Leu Pro Leu Gln Val Arg Leu Cys Pro Asp Arg Ile Ser Leu
                 325                 330                 335    
 Ile Lys Glu Cys Ile Ser Gln Ser Pro Thr Cys Tyr Lys Gln Ser Thr
             340                 345                 350        
 Lys Leu Leu Gly Leu Ala Glu Leu Leu Arg Val Ala Gly Glu Asn Pro
         355                 360                 365            
 Glu Glu Arg Arg Gly Gln Val Leu Ile Leu Leu Val Glu Gln Ala Leu
     370                 375                 380                
 Arg Phe His Asp Tyr Lys Ala Ala Ser Met His Cys Gln Glu Leu Met
 385                 390                 395                 400
 Ala Thr Gly Tyr Pro Lys Ser Trp Asp Val Cys Ser Gln Leu Gly Gln
                 405                 410                 415    
 Ser Glu Gly Tyr Gln Asp Leu Ala Thr Arg Gln Glu Leu Met Ala Phe
             420                 425                 430        
 Ala Leu Thr His Cys Pro Pro Ser Ser Ile Glu Leu Leu Leu Ala Ala
         435                 440                 445            
 Ser Ser Ser Leu Gln Thr Glu Ile Leu Tyr Gln Arg Val Asn Phe Gln
     450                 455                 460                
 Ile His His Glu Gly Gly Glu Asn Ile Ser Ala Ser Pro Leu Thr Ser
 465                 470                 475                 480
 Lys Ala Val Gln Glu Asp Glu Val Gly Val Pro Gly Ser Asn Ser Ala
                 485                 490                 495    
 Asp Leu Leu Arg Trp Thr Thr Ala Thr Thr Met Lys Val Leu Ser Asn
             500                 505                 510        
 Thr Thr Thr Thr Thr Lys Ala Val Leu Gln Ala Val Ser Asp Gly Gln
         515                 520                 525            
 Trp Trp Lys Lys Ser Leu Thr Tyr Leu Arg Pro Leu Gln Gly Gln Lys
     530                 535                 540                
 Cys Gly Gly Ala Tyr Gln Ile Gly Thr Thr Ala Asn Glu Asp Leu Glu
 545                 550                 555                 560
 Lys Gln Gly Cys His Pro Phe Tyr Glu Ser Val Ile Ser Asn Pro Phe
                 565                 570                 575    
 Val Ala Glu Ser Glu Gly Thr Tyr Asp Thr Tyr Gln His Val Pro Val
             580                 585                 590        
 Glu Ser Phe Ala Glu Val Leu Leu Arg Thr Gly Lys Leu Ala Glu Ala
         595                 600                 605            
 Lys Asn Lys Gly Glu Val Phe Pro Thr Thr Glu Val Leu Leu Gln Leu
     610                 615                 620                
 Ala Ser Glu Ala Leu Pro Asn Asp Met Thr Leu Ala Leu Ala Tyr Leu
 625                 630                 635                 640
 Leu Ala Leu Pro Gln Val Leu Asp Ala Asn Arg Cys Phe Glu Lys Gln
                 645                 650                 655    
 Ser Pro Ser Ala Leu Ser Leu Gln Leu Ala Ala Tyr Tyr Tyr Ser Leu
             660                 665                 670        
 Gln Ile Tyr Ala Arg Leu Ala Pro Cys Phe Arg Asp Lys Cys His Pro
         675                 680                 685            
 Leu Tyr Arg Ala Asp Pro Lys Glu Leu Ile Lys Met Val Thr Arg His
     690                 695                 700                
 Val Thr Arg His Glu His Glu Ala Trp Pro Glu Asp Leu Ile Ser Leu
 705                 710                 715                 720
 Thr Lys Gln Leu His Cys Tyr Asn Glu Arg Leu Leu Asp Phe Thr Gln
                 725                 730                 735    
 Ala Gln Ile Leu Gln Gly Leu Arg Lys Gly Val Asp Val Gln Arg Phe
             740                 745                 750        
 Thr Ala Asp Asp Gln Tyr Lys Arg Glu Thr Ile Leu Gly Leu Ala Glu
         755                 760                 765            
 Thr Leu Glu Glu Ser Val Tyr Ser Ile Ala Ile Ser Leu Ala Gln Arg
     770                 775                 780                
 Tyr Ser Val Ser Arg Trp Glu Val Phe Met Thr His Leu Glu Phe Leu
 785                 790                 795                 800
 Phe Thr Asp Ser Gly Leu Ser Thr Leu Glu Ile Glu Asn Arg Ala Gln
                 805                 810                 815    
 Asp Leu His Leu Phe Glu Thr Leu Lys Thr Asp Pro Glu Ala Phe His
             820                 825                 830        
 Gln His Met Val Lys Tyr Ile Tyr Pro Thr Ile Gly Gly Phe Asp His
         835                 840                 845            
 Glu Arg Leu Gln Tyr Tyr Phe Thr Leu Leu Glu Asn Cys Gly Cys Ala
     850                 855                 860                
 Asp Leu Gly Asn Cys Ala Ile Lys Pro Glu Thr His Ile Arg Leu Leu
 865                 870                 875                 880
 Lys Lys Phe Lys Val Val Ala Ser Gly Leu Asn Tyr Lys Lys Leu Thr
                 885                 890                 895    
 Asp Glu Asn Met Ser Pro Leu Glu Ala Leu Glu Pro Val Leu Ser Ser
             900                 905                 910        
 Gln Asn Ile Leu Ser Ile Ser Lys Leu Val Pro Lys Ile Pro Glu Lys
         915                 920                 925            
 Asp Gly Gln Met Leu Ser Pro Ser Ser Leu Tyr Thr Ile Trp Leu Gln
     930                 935                 940                
 Lys Leu Phe Trp Thr Gly Asp Pro His Leu Ile Lys Gln Val Pro Gly
 945                 950                 955                 960
 Ser Ser Pro Glu Trp Leu His Ala Tyr Asp Val Cys Met Lys Tyr Phe
                 965                 970                 975    
 Asp Arg Leu His Pro Gly Asp Leu Ile Thr Val Val Asp Ala Val Thr
             980                 985                 990        
 Phe Ser Pro Lys Ala Val Thr Lys Leu Ser Val Glu Ala Arg Lys Glu
         995                1000                1005            
 Met Thr Arg Lys Ala Ile Lys Thr Val Lys His Phe Ile Glu Lys Pro
    1010                1015                1020                
 Arg Lys Arg Asn Ser Glu Asp Glu Ala Gln Glu Ala Lys Asp Ser Lys
1025                1030                1035                1040
 Val Thr Tyr Ala Asp Thr Leu Asn His Leu Glu Lys Ser Leu Ala His
                1045                1050                1055    
 Leu Glu Thr Leu Ser His Ser Phe Ile Leu Ser Leu Lys Asn Ser Glu
            1060                1065                1070        
 Gln Glu Thr Leu Gln Lys Tyr Ser His Leu Tyr Asp Leu Ser Arg Ser
        1075                1080                1085            
 Glu Lys Glu Lys Leu His Asp Glu Ala Val Ala Ile Cys Leu Asp Gly
    1090                1095                1100                
 Gln Pro Leu Ala Met Ile Gln Gln Leu Leu Glu Val Ala Val Gly Pro
1105                1110                1115                1120
 Leu Asp Ile Ser Pro Lys Asp Ile Val Gln Ser Ala Ile Met Lys Ile
                1125                1130                1135    
 Ile Ser Ala Leu Ser Gly Gly Ser Ala Asp Leu Gly Gly Pro Arg Asp
            1140                1145                1150        
 Pro Leu Lys Val Leu Glu Gly Val Val Ala Ala Val His Ala Ser Val
        1155                1160                1165            
 Asp Lys Gly Glu Glu Leu Val Ser Pro Glu Asp Leu Leu Glu Trp Leu
    1170                1175                1180                
 Arg Pro Phe Cys Ala Asp Asp Ala Trp Pro Val Arg Pro Arg Ile His
1185                1190                1195                1200
 Val Leu Gln Ile Leu Gly Gln Ser Phe His Leu Thr Glu Glu Asp Ser
                1205                1210                1215    
 Lys Leu Leu Val Phe Phe Arg Thr Glu Ala Ile Leu Lys Ala Ser Trp
            1220                1225                1230        
 Pro Gln Arg Gln Val Asp Ile Ala Asp Ile Glu Asn Glu Glu Asn Arg
        1235                1240                1245            
 Tyr Cys Leu Phe Met Glu Leu Leu Glu Ser Ser His His Glu Ala Glu
    1250                1255                1260                
 Phe Gln His Leu Val Leu Leu Leu Gln Ala Trp Pro Pro Met Lys Ser
1265                1270                1275                1280
 Glu Tyr Val Ile Thr Asn Asn Pro Trp Val Arg Leu Ala Thr Val Met
                1285                1290                1295    
 Leu Thr Arg Cys Thr Met Glu Asn Lys Glu Gly Leu Gly Asn Glu Val
            1300                1305                1310        
 Leu Lys Met Cys Arg Ser Leu Tyr Asn Thr Lys Gln Met Leu Pro Ala
        1315                1320                1325            
 Glu Val Asn Asp Ser Asn Cys Asp Gln Glu Leu Leu Ser Leu Leu Leu
    1330                1335                1340                
 Asp Ala Lys Leu Leu Val Lys Cys Val Ser Thr Pro Phe Tyr Pro Arg
1345                1350                1355                1360
 Ile Val Asp His Leu Leu Ala Ser Leu Gln Gln Gly Arg Trp Asp Ala
                1365                1370                1375    
 Glu Glu Leu Gly Arg His Leu Arg Glu Ala Gly His Glu Ala Glu Ala
            1380                1385                1390        
 Gly Ser Leu Leu Leu Ala Val Arg Gly Thr His Gln Ala Phe Arg Thr
        1395                1400                1405            
 Phe Ser Thr Ala Leu Arg Ala Ala Gln His Trp Val
    1410                1415                1420



      <210> 888
      <211> 361
      <212> PRT
      <213> Homo sapiens


      <400> 888
 Met Ala Gln Arg Cys Val Cys Val Leu Ala Leu Val Ala Met Leu Leu
   1               5                  10                  15    
 Leu Val Phe Pro Thr Val Ser Arg Ser Met Gly Pro Arg Ser Gly Glu
              20                  25                  30        
 His Gln Arg Ala Ser Arg Ile Pro Ser Gln Phe Ser Lys Glu Glu Arg
          35                  40                  45            
 Val Ala Met Lys Glu Ala Leu Lys Gly Ala Ile Gln Ile Pro Thr Val
      50                  55                  60                
 Thr Phe Ser Ser Glu Lys Ser Asn Thr Thr Ala Leu Ala Glu Phe Gly
  65                  70                  75                  80
 Lys Tyr Ile His Lys Val Phe Pro Thr Val Val Ser Thr Ser Phe Ile
                  85                  90                  95    
 Gln His Glu Val Val Glu Glu Tyr Ser His Leu Phe Thr Ile Gln Gly
             100                 105                 110        
 Ser Asp Pro Ser Leu Gln Pro Tyr Leu Leu Met Ala His Phe Asp Val
         115                 120                 125            
 Val Pro Ala Pro Glu Glu Gly Trp Glu Val Pro Pro Phe Ser Gly Leu
     130                 135                 140                
 Glu Arg Asp Gly Val Ile Tyr Gly Trp Gly Thr Leu Asp Asp Lys Asn
 145                 150                 155                 160
 Ser Val Met Ala Leu Leu Gln Ala Leu Glu Leu Leu Leu Ile Arg Lys
                 165                 170                 175    
 Tyr Ile Pro Arg Arg Ser Phe Phe Ile Ser Leu Gly His Asp Glu Glu
             180                 185                 190        
 Ser Ser Gly Thr Gly Ala Gln Arg Ile Ser Ala Leu Leu Gln Ser Arg
         195                 200                 205            
 Gly Val Gln Leu Ala Phe Ile Val Asp Glu Gly Gly Phe Ile Leu Asp
     210                 215                 220                
 Asp Phe Ile Pro Asn Phe Lys Lys Pro Ile Ala Leu Ile Ala Val Ser
 225                 230                 235                 240
 Glu Lys Gly Ser Met Asn Leu Met Leu Gln Val Asn Met Thr Ser Gly
                 245                 250                 255    
 His Ser Ser Ala Pro Pro Lys Glu Thr Ser Ile Gly Ile Leu Ala Ala
             260                 265                 270        
 Ala Val Ser Arg Leu Glu Gln Thr Pro Met Pro Ile Ile Phe Gly Ser
         275                 280                 285            
 Gly Thr Val Val Thr Val Leu Gln Gln Leu Ala Asn Glu Val Tyr Gly
     290                 295                 300                
 Glu Lys Ser Leu Asn Gln Cys Asn Asn Gln Asp His His Gly Thr His
 305                 310                 315                 320
 His Ile Gln Ser Arg Gly Gln Val Gln Cys His Pro Pro Ser Gly Pro
                 325                 330                 335    
 Gly His Ser Gln Leu Pro Asp Ser Pro Trp Thr Asp Ser Pro Arg Gly
             340                 345                 350        
 Pro Arg Thr His Glu Glu His Cys Gly
         355                 360    



      <210> 889
      <211> 365
      <212> PRT
      <213> Homo sapiens


      <400> 889
 Met Ala Leu Arg Phe Leu Leu Gly Phe Leu Leu Ala Gly Val Asp Leu
   1               5                  10                  15    
 Gly Val Tyr Leu Met Arg Leu Glu Leu Cys Asp Pro Thr Gln Arg Leu
              20                  25                  30        
 Arg Val Ala Leu Ala Gly Glu Leu Val Gly Val Gly Gly His Phe Leu
          35                  40                  45            
 Phe Leu Gly Leu Ala Leu Val Ser Lys Asp Trp Arg Phe Leu Gln Arg
      50                  55                  60                
 Met Ile Thr Ala Pro Cys Ile Leu Phe Leu Phe Tyr Gly Trp Pro Gly
  65                  70                  75                  80
 Leu Phe Leu Glu Ser Ala Arg Trp Leu Ile Val Lys Arg Gln Ile Glu
                  85                  90                  95    
 Glu Ala Gln Ser Val Leu Arg Ile Leu Ala Glu Arg Asn Arg Pro His
             100                 105                 110        
 Gly Gln Met Leu Gly Glu Glu Ala Gln Glu Ala Leu Gln Asp Leu Glu
         115                 120                 125            
 Asn Thr Cys Pro Leu Pro Ala Thr Ser Ser Phe Ser Phe Ala Ser Leu
     130                 135                 140                
 Leu Asn Tyr Arg Asn Ile Trp Lys Asn Leu Leu Ile Leu Gly Phe Thr
 145                 150                 155                 160
 Asn Phe Ile Ala His Ala Ile Arg His Cys Tyr Gln Pro Val Gly Gly
                 165                 170                 175    
 Gly Gly Ser Pro Ser Asp Phe Tyr Leu Cys Ser Leu Leu Ala Ser Gly
             180                 185                 190        
 Thr Ala Ala Leu Ala Cys Val Phe Leu Gly Val Thr Val Asp Arg Phe
         195                 200                 205            
 Gly Arg Arg Gly Ile Leu Leu Leu Ser Met Thr Leu Thr Gly Ile Ala
     210                 215                 220                
 Ser Leu Val Leu Leu Gly Leu Trp Asp Leu Asn Glu Ala Ala Ile Thr
 225                 230                 235                 240
 Thr Phe Ser Val Leu Gly Leu Phe Ser Ser Gln Ala Ala Ala Ile Leu
                 245                 250                 255    
 Ser Thr Leu Leu Ala Ala Glu Val Ile Pro Thr Thr Val Arg Gly Arg
             260                 265                 270        
 Gly Leu Gly Leu Ile Met Ala Leu Gly Ala Leu Gly Gly Leu Ser Gly
         275                 280                 285            
 Pro Ala Gln Arg Leu His Met Gly His Gly Ala Phe Leu Gln His Val
     290                 295                 300                
 Val Leu Ala Ala Cys Ala Leu Leu Cys Ile Leu Ser Ile Met Leu Leu
 305                 310                 315                 320
 Pro Glu Thr Lys Arg Lys Leu Leu Pro Glu Val Leu Arg Asp Gly Glu
                 325                 330                 335    
 Leu Cys Arg Arg Pro Ser Leu Leu Arg Gln Pro Pro Pro Thr Arg Cys
             340                 345                 350        
 Asp His Val Pro Leu Leu Ala Thr Pro Asn Pro Ala Leu
         355                 360                 365



      <210> 890
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 890
 Met Tyr Ala Leu Leu Gly Val Phe Cys Leu Ala Ile Leu Val Phe Leu
   1               5                  10                  15    
 Ile Asn Cys Ala Thr Phe Ala Leu Lys Tyr Arg His Lys Gln Val Pro
              20                  25                  30        
 Leu Glu Gly Gln Ala Ser Met Thr His Ser His Asp Trp Val Trp Leu
          35                  40                  45            
 Gly Asn Glu Ala Glu Leu Leu Glu Ser Met Gly Asp Ala Pro Pro Pro
      50                  55                  60                
 Gln Asp Glu His Thr Thr Ile Ile Asp Arg Gly Pro Gly Ala Cys Glu
  65                  70                  75                  80
 Glu Ser Asn His Leu Leu Leu Asn Gly Gly Ser His Lys His Val Gln
                  85                  90                  95    
 Ser Gln Ile His Arg Ser Ala Asp Ser Gly Gly Arg Gln Gly Arg Glu
             100                 105                 110        
 Gln Lys Gln Asp Pro Leu His Ser Pro Thr Ser Lys Arg Lys Lys Val
         115                 120                 125            
 Lys Phe Thr Thr Phe Thr Thr Ile Pro Pro Asp Asp Ser Cys Pro Thr
     130                 135                 140                
 Val Asn Ser Ile Val Ser Ser Asn Asp Glu Asp Ile Lys Trp Val Cys
 145                 150                 155                 160
 Gln Asp Val Ala Val Gly Ala Pro Lys Glu Leu Arg Asn Tyr Leu Glu
                 165                 170                 175    
 Lys Leu Lys Asp Lys Ala
             180        



      <210> 891
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 891
 Met Gly Ala Pro Leu Ala Val Ala Leu Gly Ala Leu His Tyr Leu Ala
   1               5                  10                  15    
 Leu Phe Leu Gln Leu Gly Gly Ala Thr Arg Pro Ala Gly His Ala Pro
              20                  25                  30        
 Trp Asp Asn His Val Ser Gly His Ala Leu Phe Thr Glu Thr Pro His
          35                  40                  45            
 Asp Met Thr Ala Arg Thr Gly Glu Asp Val Glu Met Ala Cys Ser Phe
      50                  55                  60                
 Arg Gly Ser Gly Ser Pro Ser Tyr Ser Leu Glu Ile Gln Trp Trp Tyr
  65                  70                  75                  80
 Val Arg Ser His Arg Asp Trp Thr Asp Lys Gln Ala Trp Ala Ser Asn
                  85                  90                  95    
 Gln Val Val Lys Val Val Gly Ser Asn Ile Ser His Lys Leu Arg Leu
             100                 105                 110        
 Ser Arg Val Lys Pro Thr Asp Glu Gly Thr Tyr Glu Cys Arg Val Ile
         115                 120                 125            
 Asp Phe Ser Asp Gly Lys Ala Arg His His Lys Val Lys Ala Tyr Leu
     130                 135                 140                
 Arg Val Gln Pro Gly Glu Asn Ser Val Leu His Leu Pro Glu Ala Pro
 145                 150                 155                 160
 Pro Ala Ala Pro Ala Pro Pro Pro Pro Lys Pro Gly Lys Glu Leu Arg
                 165                 170                 175    
 Lys Arg Ser Val Asp Gln Glu Ala Cys Ser Leu
             180                 185        



      <210> 892
      <211> 1179
      <212> PRT
      <213> Homo sapiens


      <400> 892
 Met Ser Ala Glu Ser Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val
   1               5                  10                  15    
 Met Gly Asp Gly Leu Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln
              20                  25                  30        
 Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro
          35                  40                  45            
 Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln
      50                  55                  60                
 Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala
  65                  70                  75                  80
 Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp
                  85                  90                  95    
 Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys
             100                 105                 110        
 Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp
         115                 120                 125            
 Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp
     130                 135                 140                
 Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys
 145                 150                 155                 160
 Ile Asn Glu Leu Pro Thr Glu Glu Thr Glu Ile Met Ile Val Gln Ala
                 165                 170                 175    
 Lys Gly Arg Gly Arg Gly Arg Lys Glu Thr Gly Thr Ala Lys Pro Gly
             180                 185                 190        
 Val Ser Thr Val Pro Asn Thr Thr Gln Ala Ser Thr Pro Pro Gln Thr
         195                 200                 205            
 Gln Thr Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Thr Pro His Pro
     210                 215                 220                
 Phe Pro Ala Val Thr Pro Asp Leu Ile Val Gln Thr Pro Val Met Thr
 225                 230                 235                 240
 Val Val Pro Pro Gln Pro Leu Gln Thr Pro Pro Pro Val Pro Pro Gln
                 245                 250                 255    
 Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro
             260                 265                 270        
 Pro Ile Ile Ala Ala Thr Pro Gln Pro Val Lys Thr Lys Lys Gly Val
         275                 280                 285            
 Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ile Asp Pro Ile His
     290                 295                 300                
 Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Thr Thr Lys Leu Gly Gln
 305                 310                 315                 320
 Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro
                 325                 330                 335    
 Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu
             340                 345                 350        
 Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys
         355                 360                 365            
 His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala
     370                 375                 380                
 Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met
 385                 390                 395                 400
 Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln
                 405                 410                 415    
 Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr
             420                 425                 430        
 Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp
         435                 440                 445            
 Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro
     450                 455                 460                
 Val Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Thr Lys Val Val
 465                 470                 475                 480
 Ala Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser
                 485                 490                 495    
 Asp Ser Ser Thr Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala
             500                 505                 510        
 Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu
         515                 520                 525            
 Ser Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys
     530                 535                 540                
 Glu Lys Lys Lys Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn
 545                 550                 555                 560
 Lys Lys Ser Lys Ala Lys Glu Pro Pro Pro Lys Lys Thr Lys Lys Asn
                 565                 570                 575    
 Asn Ser Ser Asn Ser Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys
             580                 585                 590        
 Ser Lys Pro Pro Pro Thr Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys
         595                 600                 605            
 Pro Met Ser Tyr Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys
     610                 615                 620                
 Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg
 625                 630                 635                 640
 Glu Pro Ser Leu Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe
                 645                 650                 655    
 Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Thr
             660                 665                 670        
 Ser Cys Leu Arg Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val
         675                 680                 685            
 Ile Ala Gly Ser Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu
     690                 695                 700                
 Ser Ser Ser Glu Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Thr Glu
 705                 710                 715                 720
 Leu Ala Pro Lys Ser Lys Lys Lys Gly His Pro Gly Arg Glu Gln Lys
                 725                 730                 735    
 Lys His His His His His His Gln Gln Met Gln Gln Ala Pro Ala Pro
             740                 745                 750        
 Val Pro Gln Gln Pro Pro Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro
         755                 760                 765            
 Pro Pro Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Ser
     770                 775                 780                
 Met Pro Gln Gln Ala Ala Pro Ala Met Lys Ser Ser Pro Pro Pro Phe
 785                 790                 795                 800
 Ile Ala Thr Gln Val Pro Val Leu Glu Pro Gln Leu Pro Gly Ser Val
                 805                 810                 815    
 Phe Asp Pro Ile Gly His Phe Thr Gln Pro Ile Leu His Leu Pro Gln
             820                 825                 830        
 Pro Glu Leu Pro Pro His Leu Pro Gln Pro Pro Glu His Ser Thr Pro
         835                 840                 845            
 Pro His Leu Asn Gln His Ala Val Val Ser Pro Pro Ala Leu His Asn
     850                 855                 860                
 Ala Leu Pro Gln Gln Pro Ser Arg Pro Ser Asn Arg Ala Ala Ala Leu
 865                 870                 875                 880
 Pro Pro Lys Pro Ala Arg Pro Pro Ala Val Ser Pro Ala Leu Thr Gln
                 885                 890                 895    
 Thr Pro Leu Leu Pro Gln Pro Pro Met Ala Gln Pro Pro Gln Val Leu
             900                 905                 910        
 Leu Glu Asp Glu Glu Pro Pro Ala Pro Pro Leu Thr Ser Met Gln Met
         915                 920                 925            
 Gln Leu Tyr Leu Gln Gln Leu Gln Lys Val Gln Pro Pro Thr Pro Leu
     930                 935                 940                
 Leu Pro Ser Val Lys Val Gln Ser Gln Pro Pro Pro Pro Leu Pro Pro
 945                 950                 955                 960
 Pro Pro His Pro Ser Val Gln Gln Gln Leu Gln Gln Gln Pro Pro Pro
                 965                 970                 975    
 Pro Pro Pro Pro Gln Pro Gln Pro Pro Pro Gln Gln Gln His Gln Pro
             980                 985                 990        
 Pro Pro Arg Pro Val His Leu Gln Pro Met Gln Phe Ser Thr His Ile
         995                1000                1005            
 Gln Gln Pro Pro Pro Pro Gln Gly Gln Gln Pro Pro His Pro Pro Pro
    1010                1015                1020                
 Gly Gln Gln Pro Pro Pro Pro Gln Pro Ala Lys Pro Gln Gln Val Ile
1025                1030                1035                1040
 Gln His His His Ser Pro Arg His His Lys Ser Asp Pro Tyr Ser Thr
                1045                1050                1055    
 Gly His Leu Arg Glu Ala Pro Ser Pro Leu Met Ile His Ser Pro Gln
            1060                1065                1070        
 Met Ser Gln Phe Gln Ser Leu Thr His Gln Ser Pro Pro Gln Gln Asn
        1075                1080                1085            
 Val Gln Pro Lys Lys Gln Glu Leu Arg Ala Ala Ser Val Val Gln Pro
    1090                1095                1100                
 Gln Pro Leu Val Val Val Lys Glu Glu Lys Ile His Ser Pro Ile Ile
1105                1110                1115                1120
 Arg Ser Glu Pro Phe Ser Pro Ser Leu Arg Pro Glu Pro Pro Lys His
                1125                1130                1135    
 Pro Glu Ser Ile Lys Ala Pro Val His Leu Pro Gln Arg Pro Glu Met
            1140                1145                1150        
 Lys Pro Val Asp Val Gly Arg Pro Val Ile Arg Pro Pro Glu Gln Asn
        1155                1160                1165            
 Ala Pro Pro Pro Gly Ala Pro Asp Lys Asp Lys
    1170                1175                



      <210> 893
      <211> 478
      <212> PRT
      <213> Homo sapiens


      <400> 893
 Met Ser Pro Pro Leu Leu Lys Leu Gly Ala Val Leu Ser Thr Met Ala
   1               5                  10                  15    
 Met Ile Ser Asn Trp Met Ser Gln Thr Leu Pro Ser Leu Val Gly Leu
              20                  25                  30        
 Asn Thr Thr Arg Leu Ser Thr Pro Asp Thr Leu Thr Gln Ile Ser Pro
          35                  40                  45            
 Lys Glu Gly Trp Gln Val Tyr Ser Ser Ala Gln Asp Pro Asp Gly Arg
      50                  55                  60                
 Cys Ile Cys Thr Val Val Ala Pro Glu Gln Asn Leu Cys Ser Arg Asp
  65                  70                  75                  80
 Ala Lys Ser Arg Gln Leu Arg Gln Leu Leu Glu Lys Val Gln Asn Met
                  85                  90                  95    
 Ser Gln Ser Ile Glu Val Leu Asn Leu Arg Thr Gln Arg Asp Phe Gln
             100                 105                 110        
 Tyr Val Leu Lys Met Glu Thr Gln Met Lys Gly Leu Lys Ala Lys Phe
         115                 120                 125            
 Arg Gln Ile Glu Asp Asp Arg Lys Thr Leu Met Thr Lys His Phe Gln
     130                 135                 140                
 Glu Leu Lys Glu Lys Leu Asp Glu Leu Leu Pro Leu Ile Pro Val Leu
 145                 150                 155                 160
 Glu Gln Tyr Lys Thr Asp Ala Lys Leu Ile Thr Gln Phe Lys Glu Glu
                 165                 170                 175    
 Ile Arg Asn Leu Ser Ala Val Leu Thr Gly Ile Gln Glu Glu Ile Gly
             180                 185                 190        
 Ala Tyr Asp Tyr Glu Glu Leu His Gln Arg Val Leu Asn Leu Glu Thr
         195                 200                 205            
 Arg Leu Arg Asp Cys Met Lys Lys Leu Thr Cys Gly Lys Leu Met Lys
     210                 215                 220                
 Ile Thr Gly Pro Val Thr Val Lys Thr Ser Gly Thr Arg Phe Gly Ala
 225                 230                 235                 240
 Trp Met Thr Asp Pro Leu Ala Ser Glu Lys Asn Asn Arg Val Trp Tyr
                 245                 250                 255    
 Met Asp Ser Tyr Thr Asn Asn Lys Ile Val Arg Glu Tyr Lys Ser Ile
             260                 265                 270        
 Ala Asp Phe Val Ser Gly Ala Glu Ser Arg Thr Tyr Asn Leu Pro Phe
         275                 280                 285            
 Lys Trp Ala Gly Thr Asn His Val Val Tyr Asn Gly Ser Leu Tyr Phe
     290                 295                 300                
 Asn Lys Tyr Gln Ser Asn Ile Ile Ile Lys Tyr Ser Phe Asp Met Gly
 305                 310                 315                 320
 Arg Val Leu Ala Gln Arg Ser Leu Glu Tyr Ala Gly Phe His Asn Val
                 325                 330                 335    
 Tyr Pro Tyr Thr Trp Gly Gly Phe Ser Asp Ile Asp Leu Met Ala Asp
             340                 345                 350        
 Glu Ile Gly Leu Trp Ala Val Tyr Ala Thr Asn Gln Asn Ala Gly Asn
         355                 360                 365            
 Ile Val Ile Ser Gln Leu Asn Gln Asp Thr Leu Glu Val Met Lys Ser
     370                 375                 380                
 Trp Ser Thr Gly Tyr Pro Lys Arg Ser Ala Gly Glu Ser Phe Met Ile
 385                 390                 395                 400
 Cys Gly Thr Leu Tyr Val Thr Asn Ser His Leu Thr Gly Ala Lys Val
                 405                 410                 415    
 Tyr Tyr Ser Tyr Ser Thr Lys Thr Ser Thr Tyr Glu Tyr Thr Asp Ile
             420                 425                 430        
 Pro Phe His Asn Gln Tyr Phe His Ile Ser Met Leu Asp Tyr Asn Ala
         435                 440                 445            
 Arg Asp Arg Ala Leu Tyr Ala Trp Asn Asn Gly His Gln Val Leu Phe
     450                 455                 460                
 Asn Val Thr Leu Phe His Ile Ile Lys Thr Glu Asp Asp Thr
 465                 470                 475            



      <210> 894
      <211> 846
      <212> PRT
      <213> Homo sapiens


      <400> 894
 Met Phe Lys Cys Trp Ser Val Val Leu Val Leu Gly Phe Ile Phe Leu
   1               5                  10                  15    
 Glu Ser Glu Gly Arg Pro Thr Lys Glu Gly Gly Tyr Gly Leu Lys Ser
              20                  25                  30        
 Tyr Gln Pro Leu Met Arg Leu Arg His Lys Glu Lys Asn Gln Glu Ser
          35                  40                  45            
 Ser Arg Val Lys Gly Phe Met Ile Gln Asp Gly Pro Phe Gly Ser Cys
      50                  55                  60                
 Glu Asn Lys Tyr Cys Gly Leu Gly Arg His Cys Val Thr Ser Arg Glu
  65                  70                  75                  80
 Thr Gly Gln Ala Glu Cys Ala Cys Met Asp Leu Cys Lys Arg His Tyr
                  85                  90                  95    
 Lys Pro Val Cys Gly Ser Asp Gly Glu Phe Tyr Glu Asn His Cys Glu
             100                 105                 110        
 Val His Arg Ala Ala Cys Leu Lys Lys Gln Lys Ile Thr Ile Val His
         115                 120                 125            
 Asn Glu Asp Cys Phe Phe Lys Gly Asp Lys Cys Lys Thr Thr Glu Tyr
     130                 135                 140                
 Ser Lys Met Lys Asn Met Leu Leu Asp Leu Gln Asn Gln Lys Tyr Ile
 145                 150                 155                 160
 Met Gln Glu Asn Glu Asn Pro Asn Gly Asp Asp Ile Ser Arg Lys Lys
                 165                 170                 175    
 Leu Leu Val Asp Gln Met Phe Lys Tyr Phe Asp Ala Asp Ser Asn Gly
             180                 185                 190        
 Leu Val Asp Ile Asn Glu Leu Thr Gln Val Ile Lys Gln Glu Glu Leu
         195                 200                 205            
 Gly Lys Asp Leu Phe Asp Cys Thr Leu Tyr Val Leu Leu Lys Tyr Asp
     210                 215                 220                
 Asp Phe Asn Ala Asp Lys His Leu Ala Leu Glu Glu Phe Tyr Arg Ala
 225                 230                 235                 240
 Phe Gln Val Ile Gln Leu Ser Leu Pro Glu Asp Gln Lys Leu Ser Ile
                 245                 250                 255    
 Thr Ala Ala Thr Val Gly Gln Ser Ala Val Leu Ser Cys Ala Ile Gln
             260                 265                 270        
 Gly Thr Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn Asn Ile Ile Leu
         275                 280                 285            
 Asn Asn Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly Asp Asp Gly Ser
     290                 295                 300                
 Leu Tyr Ile Thr Lys Val Thr Thr Thr His Val Gly Asn Tyr Thr Cys
 305                 310                 315                 320
 Tyr Ala Asp Gly Tyr Glu Gln Val Tyr Gln Thr His Ile Phe Gln Val
                 325                 330                 335    
 Asn Val Pro Pro Val Ile Arg Val Tyr Pro Glu Ser Gln Ala Arg Glu
             340                 345                 350        
 Pro Gly Val Thr Ala Ser Leu Arg Cys His Ala Glu Gly Ile Pro Lys
         355                 360                 365            
 Pro Gln Leu Gly Trp Leu Lys Asn Gly Ile Asp Ile Thr Pro Lys Leu
     370                 375                 380                
 Ser Lys Gln Leu Thr Leu Gln Ala Asn Gly Ser Glu Val His Ile Ser
 385                 390                 395                 400
 Asn Val Arg Tyr Glu Asp Thr Gly Ala Tyr Thr Cys Ile Ala Lys Asn
                 405                 410                 415    
 Glu Ala Gly Val Asp Glu Asp Ile Ser Ser Leu Phe Val Glu Asp Ser
             420                 425                 430        
 Ala Arg Lys Thr Leu Ala Asn Ile Leu Trp Arg Glu Glu Gly Leu Gly
         435                 440                 445            
 Ile Gly Asn Met Phe Tyr Val Phe Tyr Glu Asp Gly Ile Lys Val Ile
     450                 455                 460                
 Gln Pro Ile Glu Cys Glu Phe Gln Arg His Ile Lys Pro Ser Glu Lys
 465                 470                 475                 480
 Leu Leu Gly Phe Gln Asp Glu Val Cys Pro Lys Ala Glu Gly Asp Glu
                 485                 490                 495    
 Val Gln Arg Cys Val Trp Ala Ser Ala Val Asn Val Lys Asp Lys Phe
             500                 505                 510        
 Ile Tyr Val Ala Gln Pro Thr Leu Asp Arg Val Leu Ile Val Asp Val
         515                 520                 525            
 Gln Ser Gln Lys Val Val Gln Ala Val Ser Thr Asp Pro Val Pro Val
     530                 535                 540                
 Lys Leu His Tyr Asp Lys Ser His Asp Gln Val Trp Val Leu Ser Trp
 545                 550                 555                 560
 Gly Thr Leu Glu Lys Thr Ser Pro Thr Leu Gln Val Ile Thr Leu Ala
                 565                 570                 575    
 Ser Gly Asn Val Pro His His Thr Ile His Thr Gln Pro Val Gly Lys
             580                 585                 590        
 Gln Phe Asp Arg Val Asp Asp Phe Phe Ile Pro Thr Thr Thr Leu Ile
         595                 600                 605            
 Ile Thr His Met Arg Phe Gly Phe Ile Leu His Lys Asp Glu Ala Ala
     610                 615                 620                
 Leu Gln Lys Ile Asp Leu Glu Thr Met Ser Tyr Ile Lys Thr Ile Asn
 625                 630                 635                 640
 Leu Lys Asp Tyr Lys Cys Val Pro Gln Ser Leu Ala Tyr Thr His Leu
                 645                 650                 655    
 Gly Gly Tyr Tyr Phe Ile Gly Cys Lys Pro Asp Ser Thr Gly Ala Val
             660                 665                 670        
 Ser Pro Gln Val Met Val Asp Gly Val Thr Asp Ser Val Ile Gly Phe
         675                 680                 685            
 Asn Ser Asp Val Thr Gly Thr Pro Tyr Val Ser Pro Asp Gly His Tyr
     690                 695                 700                
 Leu Val Ser Ile Asn Asp Val Lys Gly Leu Val Arg Val Gln Tyr Ile
 705                 710                 715                 720
 Thr Ile Arg Gly Glu Ile Gln Glu Ala Phe Asp Ile Tyr Thr Asn Leu
                 725                 730                 735    
 His Ile Ser Asp Leu Ala Phe Gln Pro Ser Phe Thr Glu Ala His Gln
             740                 745                 750        
 Tyr Asn Ile Tyr Gly Ser Ser Ser Thr Gln Thr Asp Val Leu Phe Val
         755                 760                 765            
 Glu Leu Ser Ser Gly Lys Val Lys Met Ile Lys Ser Leu Lys Glu Pro
     770                 775                 780                
 Leu Lys Ala Glu Glu Trp Pro Trp Asn Arg Lys Asn Arg Gln Ile Gln
 785                 790                 795                 800
 Asp Ser Gly Leu Phe Gly Gln Tyr Leu Met Thr Pro Ser Lys Asp Ser
                 805                 810                 815    
 Leu Phe Ile Leu Asp Gly Arg Leu Asn Lys Leu Asn Cys Glu Ile Thr
             820                 825                 830        
 Glu Val Glu Lys Gly Asn Thr Val Ile Trp Val Gly Asp Ala
         835                 840                 845    



      <210> 895
      <211> 420
      <212> PRT
      <213> Homo sapiens


      <400> 895
 Met Ser Leu Lys Phe Thr Asn Ala Lys Arg Ile Glu Gly Leu Asp Ser
   1               5                  10                  15    
 Asn Val Trp Ile Glu Phe Thr Lys Leu Ala Ala Asp Pro Ser Val Val
              20                  25                  30        
 Asn Leu Gly Gln Gly Phe Pro Asp Ile Ser Pro Pro Thr Tyr Val Lys
          35                  40                  45            
 Glu Glu Leu Ser Lys Ile Ala Ala Ile Asp Ser Leu Asn Gln Tyr Thr
      50                  55                  60                
 Arg Gly Phe Gly His Pro Ser Leu Val Lys Ala Leu Ser Tyr Leu Tyr
  65                  70                  75                  80
 Glu Lys Leu Tyr Gln Lys Gln Ile Asp Ser Asn Lys Glu Ile Leu Val
                  85                  90                  95    
 Thr Val Gly Ala Tyr Gly Ser Leu Phe Asn Thr Ile Gln Ala Leu Ile
             100                 105                 110        
 Asp Glu Gly Asp Glu Val Ile Leu Ile Val Pro Phe Tyr Asp Cys Tyr
         115                 120                 125            
 Glu Pro Met Val Arg Met Ala Gly Ala Thr Pro Val Phe Ile Pro Leu
     130                 135                 140                
 Arg Ser Lys Pro Val Tyr Gly Lys Arg Trp Ser Ser Ser Asp Trp Thr
 145                 150                 155                 160
 Leu Asp Pro Gln Glu Leu Glu Ser Lys Phe Asn Ser Lys Thr Lys Ala
                 165                 170                 175    
 Ile Ile Leu Asn Thr Pro His Asn Pro Leu Gly Lys Val Tyr Asn Arg
             180                 185                 190        
 Glu Glu Leu Gln Val Ile Ala Asp Leu Cys Ile Lys Tyr Asp Thr Leu
         195                 200                 205            
 Cys Ile Ser Asp Glu Val Tyr Glu Trp Leu Val Tyr Ser Gly Asn Lys
     210                 215                 220                
 His Leu Lys Ile Ala Thr Phe Pro Gly Met Trp Glu Arg Thr Ile Thr
 225                 230                 235                 240
 Ile Gly Ser Ala Gly Lys Thr Phe Ser Val Thr Gly Trp Lys Leu Gly
                 245                 250                 255    
 Trp Ser Ile Gly Pro Asn His Leu Ile Lys His Leu Gln Thr Val Gln
             260                 265                 270        
 Gln Asn Thr Ile Tyr Thr Cys Ala Thr Pro Leu Gln Glu Ala Leu Ala
         275                 280                 285            
 Gln Ala Phe Trp Ile Asp Ile Lys Arg Met Asp Asp Pro Gln Cys Tyr
     290                 295                 300                
 Phe Asn Ser Leu Pro Lys Glu Leu Glu Val Lys Arg Asp Arg Met Val
 305                 310                 315                 320
 Arg Leu Leu Glu Ser Val Gly Leu Lys Pro Ile Val Pro Asp Gly Gly
                 325                 330                 335    
 Tyr Ile Ile Ile Ala Asp Val Ser Leu Leu Asp Pro Asp Leu Ser Asp
             340                 345                 350        
 Met Lys Asn Asn Glu Pro Tyr Asp Tyr Lys Phe Val Lys Trp Met Thr
         355                 360                 365            
 Lys His Lys Lys Leu Ser Ala Ile Pro Val Ser Ala Phe Cys Asn Ser
     370                 375                 380                
 Glu Thr Lys Ser Gln Phe Glu Lys Phe Val Arg Phe Cys Phe Ile Lys
 385                 390                 395                 400
 Lys Asp Ser Thr Leu Asp Ala Ala Glu Glu Ile Ile Lys Ala Trp Ser
                 405                 410                 415    
 Val Gln Lys Ser
             420



      <210> 896
      <211> 573
      <212> PRT
      <213> Homo sapiens


      <400> 896
 Met Ser Ala Val Ser Gln Pro Gln Ala Ala Pro Ser Pro Leu Glu Lys
   1               5                  10                  15    
 Ser Pro Ser Thr Ala Ile Leu Cys Asn Thr Cys Gly Asn Val Cys Lys
              20                  25                  30        
 Gly Glu Val Leu Arg Val Gln Asp Lys Tyr Phe His Ile Lys Cys Phe
          35                  40                  45            
 Val Cys Lys Ala Cys Gly Cys Asp Leu Ala Glu Gly Gly Phe Phe Val
      50                  55                  60                
 Arg Gln Gly Glu Tyr Ile Cys Thr Leu Asp Tyr Gln Arg Leu Tyr Gly
  65                  70                  75                  80
 Thr Arg Cys Phe Ser Cys Asp Gln Phe Ile Glu Gly Glu Val Val Ser
                  85                  90                  95    
 Ala Leu Gly Lys Thr Tyr His Pro Asp Cys Phe Val Cys Ala Val Cys
             100                 105                 110        
 Arg Leu Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Lys Glu
         115                 120                 125            
 Cys Met Cys Gln Lys Cys Ser Leu Pro Val Ser Val Gly Ser Ser Ala
     130                 135                 140                
 His Leu Ser Gln Gly Leu Arg Ser Cys Gly Gly Cys Gly Thr Glu Ile
 145                 150                 155                 160
 Lys Asn Gly Gln Ala Leu Val Ala Leu Asp Lys His Trp His Leu Gly
                 165                 170                 175    
 Cys Phe Lys Cys Lys Ser Cys Gly Lys Leu Leu Asn Ala Glu Tyr Ile
             180                 185                 190        
 Ser Lys Asp Gly Leu Pro Tyr Cys Glu Ala Asp Tyr His Ala Lys Phe
         195                 200                 205            
 Gly Ile Arg Cys Asp Ser Cys Glu Lys Tyr Ile Thr Gly Arg Val Leu
     210                 215                 220                
 Glu Ala Gly Glu Lys His Tyr His Pro Ser Cys Ala Leu Cys Val Arg
 225                 230                 235                 240
 Cys Gly Gln Met Phe Ala Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser
                 245                 250                 255    
 Ser Ile Trp His Pro Ala Cys Arg Gln Ala Ala Arg Thr Glu Asp Arg
             260                 265                 270        
 Asn Lys Glu Thr Arg Thr Ser Ser Glu Ser Ile Ile Ser Val Pro Ala
         275                 280                 285            
 Ser Ser Thr Ser Gly Ser Pro Ser Arg Val Ile Tyr Ala Lys Leu Gly
     290                 295                 300                
 Gly Glu Ile Leu Asp Tyr Arg Asp Leu Ala Ala Leu Pro Lys Ser Lys
 305                 310                 315                 320
 Ala Ile Tyr Asp Ile Asp Arg Pro Asp Met Ile Ser Tyr Ser Pro Tyr
                 325                 330                 335    
 Ile Ser His Ser Ala Gly Asp Arg Gln Ser Tyr Gly Glu Gly Asp Gln
             340                 345                 350        
 Asp Asp Arg Ser Tyr Lys Gln Cys Arg Thr Ser Ser Pro Ser Ser Thr
         355                 360                 365            
 Gly Ser Val Ser Leu Gly Arg Tyr Thr Pro Thr Ser Arg Ser Pro Gln
     370                 375                 380                
 His Tyr Ser Arg Pro Gly Ser Glu Ser Gly Arg Ser Thr Pro Ser Leu
 385                 390                 395                 400
 Ser Val Leu Ser Asp Ser Lys Pro Pro Pro Ser Thr Tyr Gln Gln Ala
                 405                 410                 415    
 Pro Arg His Phe His Val Pro Asp Thr Gly Val Lys Asp Asn Ile Tyr
             420                 425                 430        
 Arg Lys Pro Pro Ile Tyr Arg Gln His Ala Ala Arg Arg Ser Asp Gly
         435                 440                 445            
 Glu Asp Gly Ser Leu Asp Gln Asp Asn Arg Lys Gln Lys Ser Ser Trp
     450                 455                 460                
 Leu Met Leu Lys Gly Asp Ala Asp Thr Arg Thr Asn Ser Pro Asp Leu
 465                 470                 475                 480
 Asp Thr Gln Ser Leu Ser His Ser Ser Gly Thr Asp Arg Asp Pro Leu
                 485                 490                 495    
 Gln Arg Met Ala Gly Asp Ser Phe His Ser Gln Tyr Lys Ile Tyr Pro
             500                 505                 510        
 Tyr Asp Ser Leu Ile Val Thr Asn Arg Ile Arg Val Lys Leu Pro Lys
         515                 520                 525            
 Asp Val Asp Arg Thr Arg Leu Glu Arg His Leu Ser Pro Glu Glu Phe
     530                 535                 540                
 Gln Glu Val Phe Gly Met Ser Ile Glu Glu Phe Asp Arg Leu Ala Leu
 545                 550                 555                 560
 Trp Lys Arg Asn Asp Leu Lys Lys Lys Ala Leu Leu Phe
                 565                 570            



      <210> 897
      <211> 648
      <212> PRT
      <213> Homo sapiens


      <400> 897
 Met Gly Lys Glu Pro Leu Thr Leu Lys Ser Ile Gln Val Ala Val Glu
   1               5                  10                  15    
 Glu Leu Tyr Pro Asn Lys Ala Arg Ala Leu Thr Leu Ala Gln His Ser
              20                  25                  30        
 Arg Ala Pro Ser Pro Arg Leu Arg Ser Arg Leu Phe Ser Lys Ala Leu
          35                  40                  45            
 Lys Gly Asp His Arg Cys Gly Glu Thr Glu Thr Pro Lys Ser Cys Ser
      50                  55                  60                
 Glu Val Ala Gly Cys Lys Ala Ala Met Arg His Gln Gly Lys Ile Pro
  65                  70                  75                  80
 Glu Glu Leu Ser Leu Asp Asp Arg Ala Arg Thr Gln Lys Lys Trp Gly
                  85                  90                  95    
 Arg Gly Lys Trp Glu Pro Glu Pro Ser Ser Lys Pro Pro Arg Glu Ala
             100                 105                 110        
 Thr Leu Glu Glu Arg His Ala Arg Gly Glu Lys His Leu Gly Val Glu
         115                 120                 125            
 Ile Glu Lys Thr Ser Gly Glu Ile Ile Arg Cys Glu Lys Cys Lys Arg
     130                 135                 140                
 Glu Arg Glu Leu Gln Gln Ser Leu Glu Arg Glu Arg Leu Ser Leu Gly
 145                 150                 155                 160
 Thr Ser Glu Leu Asp Met Gly Lys Gly Pro Met Tyr Asp Val Glu Lys
                 165                 170                 175    
 Leu Val Arg Thr Arg Ser Cys Arg Arg Ser Pro Glu Ala Asn Pro Ala
             180                 185                 190        
 Ser Gly Glu Glu Gly Trp Lys Gly Asp Ser His Arg Ser Ser Pro Arg
         195                 200                 205            
 Asn Pro Thr Gln Glu Leu Arg Arg Pro Ser Lys Ser Met Asp Lys Lys
     210                 215                 220                
 Glu Asp Arg Gly Pro Glu Asp Gln Glu Ser His Ala Gln Gly Ala Ala
 225                 230                 235                 240
 Lys Ala Lys Lys Asp Leu Val Glu Val Leu Pro Val Thr Glu Glu Gly
                 245                 250                 255    
 Leu Arg Glu Val Lys Lys Asp Thr Arg Pro Met Ser Arg Ser Lys His
             260                 265                 270        
 Gly Gly Trp Leu Leu Arg Glu His Gln Ala Gly Phe Glu Lys Leu Arg
         275                 280                 285            
 Arg Thr Arg Gly Glu Glu Lys Glu Ala Glu Lys Glu Lys Lys Pro Cys
     290                 295                 300                
 Met Ser Gly Gly Arg Arg Met Thr Leu Arg Asp Asp Gln Pro Ala Lys
 305                 310                 315                 320
 Leu Glu Lys Glu Pro Lys Thr Arg Pro Glu Glu Asn Lys Pro Glu Arg
                 325                 330                 335    
 Pro Ser Gly Arg Lys Pro Arg Pro Met Gly Ile Ile Ala Ala Asn Val
             340                 345                 350        
 Glu Lys His Tyr Glu Thr Gly Arg Val Ile Gly Asp Gly Asn Phe Ala
         355                 360                 365            
 Val Val Lys Glu Cys Arg His Arg Glu Thr Arg Gln Ala Tyr Ala Met
     370                 375                 380                
 Lys Ile Ile Asp Lys Ser Arg Leu Lys Gly Lys Glu Asp Met Val Asp
 385                 390                 395                 400
 Ser Glu Ile Leu Ile Ile Gln Ser Leu Ser His Pro Asn Ile Val Lys
                 405                 410                 415    
 Leu His Glu Val Tyr Glu Thr Asp Met Glu Ile Tyr Leu Ile Leu Glu
             420                 425                 430        
 Tyr Val Gln Gly Gly Asp Leu Phe Asp Ala Ile Ile Glu Ser Val Lys
         435                 440                 445            
 Phe Pro Glu Pro Asp Ala Ala Leu Met Ile Met Asp Leu Cys Lys Ala
     450                 455                 460                
 Leu Val His Met His Asp Lys Ser Ile Val His Arg Asp Leu Lys Pro
 465                 470                 475                 480
 Glu Asn Leu Leu Val Gln Arg Asn Glu Asp Lys Ser Thr Thr Leu Lys
                 485                 490                 495    
 Leu Ala Asp Phe Gly Leu Ala Lys His Val Val Arg Pro Ile Phe Thr
             500                 505                 510        
 Val Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Leu Ser Glu Lys
         515                 520                 525            
 Gly Tyr Gly Leu Glu Val Asp Met Trp Ala Ala Gly Val Ile Leu Tyr
     530                 535                 540                
 Ile Leu Leu Cys Gly Phe Pro Pro Phe Arg Ser Pro Glu Arg Asp Gln
 545                 550                 555                 560
 Asp Glu Leu Phe Asn Ile Ile Gln Leu Gly His Phe Glu Phe Leu Pro
                 565                 570                 575    
 Pro Tyr Trp Asp Asn Ile Ser Asp Ala Ala Lys Asp Leu Val Ser Arg
             580                 585                 590        
 Leu Leu Val Val Asp Pro Lys Lys Arg Tyr Thr Ala His Gln Val Leu
         595                 600                 605            
 Gln His Pro Trp Ile Glu Thr Ala Gly Lys Thr Asn Thr Val Lys Arg
     610                 615                 620                
 Gln Lys Gln Val Ser Pro Ser Ser Glu Gly His Phe Arg Ser Gln His
 625                 630                 635                 640
 Lys Arg Val Val Glu Gln Val Ser
                 645            



      <210> 898
      <211> 835
      <212> PRT
      <213> Homo sapiens


      <400> 898
 Met Ala Glu Gly Lys Glu Gly Gln Val Pro Ser Tyr Met Asp Gly Ser
   1               5                  10                  15    
 Arg Gln Arg Glu Asn Glu Glu Asp Ala Lys Ala Glu Thr Pro Asp Val
              20                  25                  30        
 Thr Ile Arg Ser Tyr Glu Ile Tyr Ser Leu Pro Trp Asn Arg Gln Gln
          35                  40                  45            
 Gly Val Cys Asp His Ser Leu Glu Tyr Leu Ser Ser Arg Ile Ser Glu
      50                  55                  60                
 Arg Lys Leu Gln Gly Ser Trp Leu Pro Ala Ser Arg Gly Asn Leu Glu
  65                  70                  75                  80
 Lys Pro Phe Leu Gly Pro Arg Gly Pro Val Val Pro Leu Phe Cys Pro
                  85                  90                  95    
 Arg Asn Gly Leu His Ser Ala His Pro Glu Asn Ser Pro Leu Lys Pro
             100                 105                 110        
 Arg Val Val Thr Val Val Lys Leu Gly Gly Gln Arg Pro Arg Lys Ile
         115                 120                 125            
 Thr Leu Leu Leu Asn Arg Arg Ser Val Gln Thr Phe Glu Gln Leu Leu
     130                 135                 140                
 Ala Asp Ile Ser Glu Ala Leu Gly Ser Pro Arg Trp Lys Asn Asp Arg
 145                 150                 155                 160
 Val Arg Lys Leu Phe Asn Leu Lys Gly Arg Glu Ile Arg Ser Val Ser
                 165                 170                 175    
 Asp Phe Phe Arg Glu Gly Asp Ala Phe Ile Ala Met Gly Lys Glu Pro
             180                 185                 190        
 Leu Thr Leu Lys Ser Ile Gln Val Ala Val Glu Glu Leu Tyr Pro Asn
         195                 200                 205            
 Lys Ala Arg Ala Leu Thr Leu Ala Gln His Ser Arg Ala Pro Ser Pro
     210                 215                 220                
 Arg Leu Arg Ser Arg Leu Phe Ser Lys Ala Leu Lys Gly Asp His Arg
 225                 230                 235                 240
 Cys Gly Glu Thr Glu Thr Pro Lys Ser Cys Ser Glu Val Ala Gly Cys
                 245                 250                 255    
 Lys Ala Ala Met Arg His Gln Gly Lys Ile Pro Glu Glu Leu Ser Leu
             260                 265                 270        
 Asp Asp Arg Ala Arg Thr Gln Lys Lys Trp Gly Arg Gly Lys Trp Glu
         275                 280                 285            
 Pro Glu Pro Ser Ser Lys Pro Pro Arg Glu Ala Thr Leu Glu Glu Arg
     290                 295                 300                
 His Ala Arg Gly Glu Lys His Leu Gly Val Glu Ile Glu Lys Thr Ser
 305                 310                 315                 320
 Gly Glu Ile Ile Arg Cys Glu Lys Cys Lys Arg Glu Arg Glu Leu Gln
                 325                 330                 335    
 Gln Ser Leu Glu Arg Glu Arg Leu Ser Leu Gly Thr Ser Glu Leu Asp
             340                 345                 350        
 Met Gly Lys Gly Pro Met Tyr Asp Val Glu Lys Leu Val Arg Thr Arg
         355                 360                 365            
 Ser Cys Arg Arg Ser Pro Glu Ala Asn Pro Ala Ser Gly Glu Glu Gly
     370                 375                 380                
 Trp Lys Gly Asp Ser His Arg Ser Ser Pro Arg Asn Pro Thr Gln Glu
 385                 390                 395                 400
 Leu Arg Arg Pro Ser Lys Ser Met Asp Lys Lys Glu Asp Arg Gly Pro
                 405                 410                 415    
 Glu Asp Gln Glu Ser His Ala Gln Gly Ala Ala Lys Ala Lys Lys Asp
             420                 425                 430        
 Leu Val Glu Val Leu Pro Val Thr Glu Glu Gly Leu Arg Glu Val Lys
         435                 440                 445            
 Lys Asp Thr Arg Pro Met Ser Arg Ser Lys His Gly Gly Trp Leu Leu
     450                 455                 460                
 Arg Glu His Gln Ala Gly Phe Glu Lys Leu Arg Arg Thr Arg Gly Glu
 465                 470                 475                 480
 Glu Lys Glu Ala Glu Lys Glu Lys Lys Pro Cys Met Ser Gly Gly Arg
                 485                 490                 495    
 Arg Met Thr Leu Arg Asp Asp Gln Pro Ala Lys Leu Glu Lys Glu Pro
             500                 505                 510        
 Lys Thr Arg Pro Glu Glu Asn Lys Pro Glu Arg Pro Ser Gly Arg Lys
         515                 520                 525            
 Pro Arg Pro Met Gly Ile Ile Ala Ala Asn Val Glu Lys His Tyr Glu
     530                 535                 540                
 Thr Gly Arg Val Ile Gly Asp Gly Asn Phe Ala Val Val Lys Glu Cys
 545                 550                 555                 560
 Arg His Arg Glu Thr Arg Gln Ala Tyr Ala Met Lys Ile Ile Asp Lys
                 565                 570                 575    
 Ser Arg Leu Lys Gly Lys Glu Asp Met Val Asp Ser Glu Ile Leu Ile
             580                 585                 590        
 Ile Gln Ser Leu Ser His Pro Asn Ile Val Lys Leu His Glu Val Tyr
         595                 600                 605            
 Glu Thr Asp Met Glu Ile Tyr Leu Ile Leu Glu Tyr Val Gln Gly Gly
     610                 615                 620                
 Asp Leu Phe Asp Ala Ile Ile Glu Ser Val Lys Phe Pro Glu Pro Asp
 625                 630                 635                 640
 Ala Ala Leu Met Ile Met Asp Leu Cys Lys Ala Leu Val His Met His
                 645                 650                 655    
 Asp Lys Ser Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Val
             660                 665                 670        
 Gln Arg Asn Glu Asp Lys Ser Thr Thr Leu Lys Leu Ala Asp Phe Gly
         675                 680                 685            
 Leu Ala Lys His Val Val Arg Pro Ile Phe Thr Val Cys Gly Thr Pro
     690                 695                 700                
 Thr Tyr Val Ala Pro Glu Ile Leu Ser Glu Lys Gly Tyr Gly Leu Glu
 705                 710                 715                 720
 Val Asp Met Trp Ala Ala Gly Val Ile Leu Tyr Ile Leu Leu Cys Gly
                 725                 730                 735    
 Phe Pro Pro Phe Arg Ser Pro Glu Arg Asp Gln Asp Glu Leu Phe Asn
             740                 745                 750        
 Ile Ile Gln Leu Gly His Phe Glu Phe Leu Pro Pro Tyr Trp Asp Asn
         755                 760                 765            
 Ile Ser Asp Ala Ala Lys Asp Leu Val Ser Arg Leu Leu Val Val Asp
     770                 775                 780                
 Pro Lys Lys Arg Tyr Thr Ala His Gln Val Leu Gln His Pro Trp Ile
 785                 790                 795                 800
 Glu Thr Ala Gly Lys Thr Asn Thr Val Lys Arg Gln Lys Gln Val Ser
                 805                 810                 815    
 Pro Ser Ser Glu Gly His Phe Arg Ser Gln His Lys Arg Val Val Glu
             820                 825                 830        
 Gln Val Ser
         835



      <210> 899
      <211> 377
      <212> PRT
      <213> Homo sapiens


      <400> 899
 Met Asp Pro Ala Ala Arg Val Val Arg Ala Leu Trp Pro Gly Gly Cys
   1               5                  10                  15    
 Ala Leu Ala Trp Arg Leu Gly Gly Arg Pro Gln Pro Leu Leu Pro Thr
              20                  25                  30        
 Gln Ser Arg Ala Gly Phe Ala Gly Ala Ala Gly Gly Pro Ser Pro Val
          35                  40                  45            
 Ala Ala Ala Arg Lys Gly Ser Pro Arg Leu Leu Gly Ala Ala Ala Leu
      50                  55                  60                
 Ala Leu Gly Gly Ala Leu Gly Leu Tyr His Thr Ala Arg Trp His Leu
  65                  70                  75                  80
 Arg Ala Gln Asp Leu His Ala Glu Arg Ser Ala Ala Gln Leu Ser Leu
                  85                  90                  95    
 Ser Ser Arg Leu Gln Leu Thr Leu Tyr Gln Tyr Lys Thr Cys Pro Phe
             100                 105                 110        
 Cys Ser Lys Val Arg Ala Phe Leu Asp Phe His Ala Leu Pro Tyr Gln
         115                 120                 125            
 Val Val Glu Val Asn Pro Val Arg Arg Ala Glu Ile Lys Phe Ser Ser
     130                 135                 140                
 Tyr Arg Lys Val Pro Ile Leu Val Ala Gln Glu Gly Glu Ser Ser Gln
 145                 150                 155                 160
 Gln Leu Asn Asp Ser Ser Val Ile Ile Ser Ala Leu Lys Thr Tyr Leu
                 165                 170                 175    
 Val Ser Gly Gln Pro Leu Glu Glu Ile Ile Thr Tyr Tyr Pro Ala Met
             180                 185                 190        
 Lys Ala Val Asn Glu Gln Gly Lys Glu Val Thr Glu Phe Gly Asn Lys
         195                 200                 205            
 Tyr Trp Leu Met Leu Asn Glu Lys Glu Ala Gln Gln Val Tyr Gly Gly
     210                 215                 220                
 Lys Glu Ala Arg Thr Glu Glu Met Lys Trp Arg Gln Trp Ala Asp Asp
 225                 230                 235                 240
 Trp Leu Val His Leu Ile Ser Pro Asn Val Tyr Arg Thr Pro Thr Glu
                 245                 250                 255    
 Ala Leu Ala Ser Phe Asp Tyr Ile Val Arg Glu Gly Lys Phe Gly Ala
             260                 265                 270        
 Val Glu Gly Ala Val Ala Lys Tyr Met Gly Ala Ala Ala Met Tyr Leu
         275                 280                 285            
 Ile Ser Lys Arg Leu Lys Ser Arg His Arg Leu Gln Asp Asn Val Arg
     290                 295                 300                
 Glu Asp Leu Tyr Glu Ala Ala Asp Lys Trp Val Ala Ala Val Gly Lys
 305                 310                 315                 320
 Asp Arg Pro Phe Met Gly Gly Gln Lys Pro Asn Leu Ala Asp Leu Ala
                 325                 330                 335    
 Val Tyr Gly Val Leu Arg Val Met Glu Gly Leu Asp Ala Phe Asp Asp
             340                 345                 350        
 Leu Met Gln His Thr His Ile Gln Pro Trp Tyr Leu Arg Val Glu Arg
         355                 360                 365            
 Ala Ile Thr Glu Ala Ser Pro Ala His
     370                 375        



      <210> 900
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 900
 Met Glu Gly Pro Arg Gly Trp Leu Val Leu Ser Val Leu Ala Ile Ser
   1               5                  10                  15    
 Leu Ala Ser Met Val Thr Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys
              20                  25                  30        
 Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys
          35                  40                  45            
 Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Thr Gly Ile Gln
      50                  55                  60                
 Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly
  65                  70                  75                  80
 Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile
                  85                  90                  95    
 Pro Gly Ile Lys Gly Thr Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln
             100                 105                 110        
 Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly
         115                 120                 125            
 Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr
     130                 135                 140                
 Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr
 145                 150                 155                 160
 Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val
                 165                 170                 175    
 Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr
             180                 185                 190        
 Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln
         195                 200                 205            
 Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly
     210                 215                 220                
 His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu
 225                 230                 235                 240
 Ile Phe Pro Ser Ala
                 245



      <210> 901
      <211> 219
      <212> PRT
      <213> Homo sapiens


      <400> 901
 Met Ala Leu Ser Trp Leu Gln Arg Val Glu Leu Ala Leu Phe Ala Ala
   1               5                  10                  15    
 Ala Phe Leu Cys Gly Ala Val Ala Ala Ala Ala Met Thr Arg Thr Gln
              20                  25                  30        
 Gly Ser Phe Ser Gly Arg Cys Pro Leu Tyr Gly Val Ala Thr Leu Asn
          35                  40                  45            
 Gly Ser Ser Leu Ala Leu Ser Arg Pro Ser Ala Pro Ser Leu Cys Tyr
      50                  55                  60                
 Phe Val Ala Gly Ala Ser Gly Leu Leu Ala Leu Tyr Cys Leu Leu Leu
  65                  70                  75                  80
 Leu Leu Phe Trp Ile Tyr Ser Ser Cys Ile Glu Asp Ser His Arg Gly
                  85                  90                  95    
 Ala Ile Gly Leu Arg Ile Ala Leu Ala Ile Ser Ala Ile Ala Val Phe
             100                 105                 110        
 Leu Val Leu Val Ser Ala Cys Ile Leu Arg Phe Gly Thr Arg Ser Leu
         115                 120                 125            
 Cys Asn Ser Ile Ile Ser Leu Asn Thr Thr Ile Ser Cys Ser Glu Ala
     130                 135                 140                
 Gln Lys Ile Pro Trp Thr Pro Pro Gly Thr Ala Leu Gln Phe Tyr Ser
 145                 150                 155                 160
 Asn Leu His Asn Ala Glu Thr Ser Ser Trp Val Asn Leu Val Leu Trp
                 165                 170                 175    
 Cys Val Val Leu Val Leu Gln Val Val Gln Trp Lys Ser Glu Ala Thr
             180                 185                 190        
 Pro Tyr Arg Pro Leu Glu Arg Gly Asp Pro Glu Trp Ser Ser Glu Thr
         195                 200                 205            
 Asp Ala Leu Val Gly Ser Arg Leu Ser His Ser
     210                 215                



      <210> 902
      <211> 945
      <212> PRT
      <213> Homo sapiens


      <400> 902
 Met Ser Asp Gln Ala Pro Lys Val Pro Glu Glu Met Phe Arg Glu Val
   1               5                  10                  15    
 Lys Tyr Tyr Ala Val Gly Asp Ile Asp Pro Gln Val Ile Gln Leu Leu
              20                  25                  30        
 Lys Ala Gly Lys Ala Lys Glu Val Ser Tyr Asn Ala Leu Ala Ser His
          35                  40                  45            
 Ile Ile Ser Glu Asp Gly Asp Asn Pro Glu Val Gly Glu Ala Arg Glu
      50                  55                  60                
 Val Phe Asp Leu Pro Val Val Lys Pro Ser Trp Val Ile Leu Ser Val
  65                  70                  75                  80
 Gln Cys Gly Thr Leu Leu Pro Val Asn Gly Phe Ser Pro Glu Ser Cys
                  85                  90                  95    
 Gln Ile Phe Phe Gly Ile Thr Ala Cys Leu Ser Gln Val Ser Ser Glu
             100                 105                 110        
 Asp Arg Ser Ala Leu Trp Ala Leu Val Thr Phe Tyr Gly Gly Asp Cys
         115                 120                 125            
 Gln Leu Thr Leu Asn Lys Lys Cys Thr His Leu Ile Val Pro Glu Pro
     130                 135                 140                
 Lys Gly Glu Lys Tyr Glu Cys Ala Leu Lys Arg Ala Ser Ile Lys Ile
 145                 150                 155                 160
 Val Thr Pro Asp Trp Val Leu Asp Cys Val Ser Glu Lys Thr Lys Lys
                 165                 170                 175    
 Asp Glu Ala Phe Tyr His Pro Arg Leu Ile Ile Tyr Glu Glu Glu Glu
             180                 185                 190        
 Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Asn Glu Glu Gln Asp Ser
         195                 200                 205            
 Gln Asn Glu Gly Ser Thr Asp Glu Lys Ser Ser Pro Ala Ser Ser Gln
     210                 215                 220                
 Glu Gly Ser Pro Ser Gly Asp Gln Gln Phe Ser Pro Lys Ser Asn Thr
 225                 230                 235                 240
 Glu Lys Ser Lys Gly Glu Leu Met Phe Asp Asp Ser Ser Asp Ser Ser
                 245                 250                 255    
 Pro Glu Lys Gln Glu Arg Asn Leu Asn Trp Thr Pro Ala Glu Val Pro
             260                 265                 270        
 Gln Leu Ala Ala Ala Lys Arg Arg Leu Pro Gln Gly Lys Glu Pro Gly
         275                 280                 285            
 Leu Ile Asn Leu Cys Ala Asn Val Pro Pro Val Pro Gly Asn Ile Leu
     290                 295                 300                
 Pro Pro Glu Val Arg Gly Asn Leu Met Ala Ala Gly Gln Asn Leu Gln
 305                 310                 315                 320
 Ser Ser Glu Arg Ser Glu Met Ile Ala Thr Trp Ser Pro Ala Val Arg
                 325                 330                 335    
 Thr Leu Arg Asn Ile Thr Asn Asn Ala Asp Ile Gln Gln Met Asn Arg
             340                 345                 350        
 Pro Ser Asn Val Ala His Ile Leu Gln Thr Leu Ser Ala Pro Thr Lys
         355                 360                 365            
 Asn Leu Glu Gln Gln Val Asn His Ser Gln Gln Gly His Thr Asn Ala
     370                 375                 380                
 Asn Ala Val Leu Phe Ser Gln Val Lys Val Thr Pro Glu Thr His Met
 385                 390                 395                 400
 Leu Gln Gln Gln Gln Gln Ala Gln Gln Gln Gln Gln Gln His Pro Val
                 405                 410                 415    
 Leu His Leu Gln Pro Gln Gln Ile Met Gln Leu Gln Gln Gln Gln Gln
             420                 425                 430        
 Gln Gln Ile Ser Gln Gln Pro Tyr Pro Gln Gln Pro Pro His Pro Phe
         435                 440                 445            
 Ser Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Ser Pro Gln Gln
     450                 455                 460                
 His Gln Leu Phe Gly His Asp Pro Ala Val Glu Ile Pro Glu Glu Gly
 465                 470                 475                 480
 Phe Leu Leu Gly Cys Val Phe Ala Ile Ala Asp Tyr Pro Glu Gln Met
                 485                 490                 495    
 Ser Asp Lys Gln Leu Leu Ala Thr Trp Lys Arg Ile Ile Gln Ala His
             500                 505                 510        
 Gly Gly Thr Val Asp Pro Thr Phe Thr Ser Arg Cys Thr His Leu Leu
         515                 520                 525            
 Cys Glu Ser Gln Val Ser Ser Ala Tyr Ala Gln Ala Ile Arg Glu Arg
     530                 535                 540                
 Lys Arg Cys Val Thr Ala His Trp Leu Asn Thr Val Leu Lys Lys Lys
 545                 550                 555                 560
 Lys Met Val Pro Pro His Arg Ala Leu His Phe Pro Val Ala Phe Pro
                 565                 570                 575    
 Pro Gly Gly Lys Pro Cys Ser Gln His Ile Ile Ser Val Thr Gly Phe
             580                 585                 590        
 Val Asp Ser Asp Arg Asp Asp Leu Lys Leu Met Ala Tyr Leu Ala Gly
         595                 600                 605            
 Ala Lys Tyr Thr Gly Tyr Leu Cys Arg Ser Asn Thr Val Leu Ile Cys
     610                 615                 620                
 Lys Glu Pro Thr Gly Leu Lys Tyr Glu Lys Ala Lys Glu Trp Arg Ile
 625                 630                 635                 640
 Pro Cys Val Asn Ala Gln Trp Leu Gly Asp Ile Leu Leu Gly Asn Phe
                 645                 650                 655    
 Glu Ala Leu Arg Gln Ile Gln Tyr Ser Arg Tyr Thr Ala Phe Ser Leu
             660                 665                 670        
 Gln Asp Pro Phe Ala Pro Thr Gln His Leu Val Leu Asn Leu Leu Asp
         675                 680                 685            
 Ala Trp Arg Val Pro Leu Lys Val Ser Ala Glu Leu Leu Met Ser Ile
     690                 695                 700                
 Arg Leu Pro Pro Lys Leu Lys Gln Asn Glu Val Ala Asn Val Gln Pro
 705                 710                 715                 720
 Ser Ser Lys Arg Ala Arg Ile Glu Asp Val Pro Pro Pro Thr Lys Lys
                 725                 730                 735    
 Leu Thr Pro Glu Leu Thr Pro Phe Val Leu Phe Thr Gly Phe Glu Pro
             740                 745                 750        
 Val Gln Val Gln Gln Tyr Ile Lys Lys Leu Tyr Ile Leu Gly Gly Glu
         755                 760                 765            
 Val Ala Glu Ser Ala Gln Lys Cys Thr His Leu Ile Ala Ser Lys Val
     770                 775                 780                
 Thr Arg Thr Val Lys Phe Leu Thr Ala Ile Ser Val Val Lys His Ile
 785                 790                 795                 800
 Val Thr Pro Glu Trp Leu Glu Glu Cys Phe Arg Cys Gln Lys Phe Ile
                 805                 810                 815    
 Asp Glu Gln Asn Tyr Ile Leu Arg Asp Ala Glu Ala Glu Val Leu Phe
             820                 825                 830        
 Ser Phe Ser Leu Glu Glu Ser Leu Lys Arg Ala His Val Ser Pro Leu
         835                 840                 845            
 Phe Lys Ala Lys Tyr Phe Tyr Ile Thr Pro Gly Ile Cys Pro Ser Leu
     850                 855                 860                
 Ser Thr Met Lys Ala Ile Val Glu Cys Ala Gly Gly Lys Val Leu Ser
 865                 870                 875                 880
 Lys Gln Pro Ser Phe Arg Lys Leu Met Glu His Lys Gln Asn Ser Ser
                 885                 890                 895    
 Leu Ser Glu Ile Ile Leu Ile Ser Cys Glu Asn Asp Leu His Leu Cys
             900                 905                 910        
 Arg Glu Tyr Phe Ala Arg Gly Ile Asp Val His Asn Ala Glu Phe Val
         915                 920                 925            
 Leu Thr Gly Val Leu Thr Gln Thr Leu Asp Tyr Glu Ser Tyr Lys Phe
     930                 935                 940                
 Asn
 945



      <210> 903
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 903
 Met Ser Asp Gln Ala Pro Lys Val Pro Glu Glu Met Phe Arg Glu Val
   1               5                  10                  15    
 Lys Tyr Tyr Ala Val Gly Asp Ile Asp Pro Gln Val Ile Gln Leu Leu
              20                  25                  30        
 Lys Ala Gly Lys Ala Lys Glu Val Ser Tyr Asn Ala Leu Ala Ser His
          35                  40                  45            
 Ile Ile Ser Glu Asp Gly Asp Asn Pro Glu Val Gly Glu Ala Arg Glu
      50                  55                  60                
 Val Phe Asp Leu Pro Val Val Lys Pro Ser Trp Val Ile Leu Ser Val
  65                  70                  75                  80
 Gln Cys Gly Thr Leu Leu Pro Val Asn Gly Phe Ser Pro Glu Ser Cys
                  85                  90                  95    
 Gln Ile Phe Phe Gly Ile Thr Ala Cys Leu Ser Gln Gly Val Asp Thr
             100                 105                 110        
 Ser Trp Ser Ser Leu Leu Glu Ser Ser Arg Ala Leu Pro Arg Arg Gly
         115                 120                 125            
 Arg Glu Gly Ser Leu Ser Ser Arg Ser Trp Glu Ala Gln Arg Ser Ser
     130                 135                 140                
 Ala Phe Phe
 145        



      <210> 904
      <211> 285
      <212> PRT
      <213> Homo sapiens


      <400> 904
 Met Ala Pro Gln Arg Arg Ala Ala Thr Lys Ala Pro Glu Gly Asn Gly
   1               5                  10                  15    
 Ala Ala Glu Arg Arg Asn Arg Ser Ser Thr Lys Lys Asp Arg Ala Pro
              20                  25                  30        
 Arg Glu Val Gln Arg Leu Trp Gln Arg Pro Trp Leu Arg Thr Ala Gly
          35                  40                  45            
 Leu Gly Ala Gly Phe Val Leu Thr Ala Leu Leu Leu Trp Ser Ser Leu
      50                  55                  60                
 Gly Ala Asp Asp Gly Val Ala Glu Val Leu Ala Arg Arg Gly Glu Val
  65                  70                  75                  80
 Val Ala Gly Arg Phe Ile Glu Val Pro Cys Ser Glu Asp Tyr Asp Ser
                  85                  90                  95    
 His Arg Arg Phe Glu Gly Cys Thr Pro Arg Lys Cys Gly Arg Gly Val
             100                 105                 110        
 Thr Asp Val Val Ile Thr Arg Glu Glu Ala Glu Arg Ile Arg Ser Val
         115                 120                 125            
 Ala Glu Lys Gly Leu Ser Leu Gly Gly Ser Asp Gly Gly Ala Ser Ile
     130                 135                 140                
 Leu Asp Leu His Ser Gly Ala Leu Ser Val Gly Lys His Phe Val Asn
 145                 150                 155                 160
 Leu Tyr Arg Tyr Phe Gly Asp Lys Ile Gln Asn Ile Phe Ser Glu Glu
                 165                 170                 175    
 Asp Phe Arg Leu Tyr Arg Thr Glu Ala Arg Thr Ala His Asp Glu Tyr
             180                 185                 190        
 Trp His Ala His Val Asp Lys Val Thr Tyr Gly Ser Phe Asp Tyr Thr
         195                 200                 205            
 Ser Leu Leu Tyr Leu Ser Asn Tyr Leu Glu Asp Phe Gly Gly Gly Arg
     210                 215                 220                
 Phe Met Phe Met Glu Glu Gly Ala Asn Lys Thr Val Glu Pro Arg Ala
 225                 230                 235                 240
 Gly Arg Val Ser Phe Phe Thr Ser Gly Ser Glu Asn Leu His Arg Val
                 245                 250                 255    
 Glu Lys Val His Trp Gly Thr Arg Tyr Ala Ile Thr Ile Ala Phe Ser
             260                 265                 270        
 Cys Asn Pro Asp His Gly Ile Glu Asp Pro Ala Phe Pro
         275                 280                 285



      <210> 905
      <211> 300
      <212> PRT
      <213> Homo sapiens


      <400> 905
 Met Gly Ala Ser Leu Lys Ile Leu Asn Leu Ser Phe Asn Asn Leu Thr
   1               5                  10                  15    
 Ala Leu His Pro Arg Val Leu Lys Pro Leu Ser Ser Leu Ile His Leu
              20                  25                  30        
 Gln Ala Asn Ser Asn Pro Trp Glu Cys Asn Cys Lys Leu Leu Gly Leu
          35                  40                  45            
 Arg Asp Trp Leu Ala Ser Ser Ala Ile Thr Leu Asn Ile Tyr Cys Gln
      50                  55                  60                
 Asn Pro Pro Ser Met Arg Gly Arg Ala Leu Arg Tyr Ile Asn Ile Thr
  65                  70                  75                  80
 Asn Cys Val Thr Ser Ser Ile Asn Val Ser Arg Ala Trp Ala Val Val
                  85                  90                  95    
 Lys Ser Pro His Ile His His Lys Thr Thr Ala Leu Met Met Ala Trp
             100                 105                 110        
 His Lys Val Thr Thr Asn Gly Ser Pro Leu Glu Asn Thr Glu Thr Glu
         115                 120                 125            
 Asn Ile Thr Phe Trp Glu Arg Ile Pro Thr Ser Pro Ala Gly Arg Phe
     130                 135                 140                
 Phe Gln Glu Asn Ala Phe Gly Asn Pro Leu Glu Thr Thr Ala Val Leu
 145                 150                 155                 160
 Pro Val Gln Ile Gln Leu Thr Thr Ser Val Thr Leu Asn Leu Glu Lys
                 165                 170                 175    
 Asn Ser Ala Leu Pro Asn Asp Ala Ala Ser Met Ser Gly Lys Thr Ser
             180                 185                 190        
 Leu Ile Cys Thr Gln Glu Val Glu Lys Leu Asn Glu Ala Phe Asp Ile
         195                 200                 205            
 Leu Leu Ala Phe Phe Ile Leu Ala Cys Val Leu Ile Ile Phe Leu Ile
     210                 215                 220                
 Tyr Lys Val Val Gln Phe Lys Gln Lys Leu Lys Ala Ser Glu Asn Ser
 225                 230                 235                 240
 Arg Glu Asn Arg Leu Glu Tyr Tyr Ser Phe Tyr Gln Ser Ala Arg Tyr
                 245                 250                 255    
 Asn Val Thr Ala Ser Ile Cys Asn Thr Ser Pro Asn Ser Leu Glu Ser
             260                 265                 270        
 Pro Gly Leu Glu Gln Ile Arg Leu His Lys Gln Ile Val Pro Glu Asn
         275                 280                 285            
 Glu Ala Gln Val Ile Leu Phe Glu His Ser Ala Leu
     290                 295                 300



      <210> 906
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 906
 Met Thr Val Phe Gln Gly Asp Gly Thr Ala Ser Thr Thr Leu Arg Asn
   1               5                  10                  15    
 Gly Ser Ala Leu Ser Val Leu Glu Gly Gln Ser Leu His Leu Val Cys
              20                  25                  30        
 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp Gly Ser
          35                  40                  45            
 Leu Thr Leu Ser Pro Ser Gln Ser Ser Asn Leu Gly Val Leu Glu Leu
      50                  55                  60                
 Pro Arg Val His Val Lys Asp Glu Gly Glu Phe Thr Cys Arg Ala Gln
  65                  70                  75                  80
 Asn Pro Leu Gly Ser Gln His Ile Ser Leu Ser Leu Ser Leu Gln Asn
                  85                  90                  95    
 Glu Tyr Thr Gly Lys Met Arg Pro Ile Ser Gly Val Thr Leu Gly Ala
             100                 105                 110        
 Phe Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Tyr Phe Cys Ile
         115                 120                 125            
 Ile Phe Val Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala
     130                 135                 140                
 Val Gly Val Gly Asp Thr Gly Met Glu Asp Ala Asn Ala Val Arg Gly
 145                 150                 155                 160
 Ser Ala Ser Gln Gly Pro Leu Ile Glu Ser Pro Ala Asp Asp Ser Pro
                 165                 170                 175    
 Pro His His Ala Pro Pro Ala Leu Ala Thr Pro Ser Pro Glu Glu Gly
             180                 185                 190        
 Glu Ile Gln Tyr Ala Ser Leu Ser Phe His Lys Ala Arg Pro Gln Tyr
         195                 200                 205            
 Pro Gln Glu Gln Glu Ala Ile Gly Tyr Glu Tyr Ser Glu Ile Asn Ile
     210                 215                 220                
 Pro Lys
 225    



      <210> 907
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 907
 Met Val Ser Trp Met Ile Ser Arg Ala Val Val Leu Val Phe Gly Met
   1               5                  10                  15    
 Leu Tyr Pro Ala Tyr Tyr Ser Tyr Lys Ala Val Lys Thr Lys Asn Val
              20                  25                  30        
 Lys Glu Tyr Val Arg Trp Met Met Tyr Trp Ile Val Phe Ala Leu Tyr
          35                  40                  45            
 Thr Val Ile Glu Thr Val Ala Asp Gln Thr Val Ala Trp Phe Pro Leu
      50                  55                  60                
 Tyr Tyr Glu Leu Lys Ile Ala Phe Val Ile Trp Leu Leu Ser Pro Tyr
  65                  70                  75                  80
 Thr Lys Gly Ala Ser Leu Ile Tyr Arg Lys Phe Leu His Pro Leu Leu
                  85                  90                  95    
 Ser Ser Lys Glu Arg Glu Ile Asp Asp Tyr Ile Val Gln Ala Lys Glu
             100                 105                 110        
 Arg Gly Tyr Glu Thr Met Val Asn Phe Gly Arg Gln Gly Leu Asn Leu
         115                 120                 125            
 Ala Ala Thr Ala Ala Val Thr Ala Ala Val Lys Ser Gln Gly Ala Ile
     130                 135                 140                
 Thr Glu Arg Leu Arg Ser Phe Ser Met His Asp Leu Thr Thr Ile Gln
 145                 150                 155                 160
 Gly Asp Glu Pro Val Gly Gln Arg Pro Tyr Gln Pro Leu Pro Glu Ala
                 165                 170                 175    
 Lys Lys Lys Lys Lys Arg Arg Pro Leu
             180                 185



      <210> 908
      <211> 1507
      <212> PRT
      <213> Homo sapiens


      <400> 908
 Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly
   1               5                  10                  15    
 Trp Cys Leu Pro Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe Lys
              20                  25                  30        
 Ser Thr Val Arg Cys Met His Leu Met Leu Asp His Ile Pro Gln Val
          35                  40                  45            
 Pro Gln Gln Thr Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu
      50                  55                  60                
 Ile Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu Tyr
  65                  70                  75                  80
 Leu Tyr Lys Asn His Ile Arg Lys Ile Ser Arg Asn Ala Phe Glu Gly
                  85                  90                  95    
 Leu Glu Asn Leu Leu Tyr Leu Tyr Ile His Phe Asn Gln Leu Glu Met
             100                 105                 110        
 Leu Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg Leu Phe
         115                 120                 125            
 Leu His Asn Asn Lys Leu Ser Lys Ile Pro Ala Gly Ser Phe Ser Asn
     130                 135                 140                
 Leu Asp Ser Leu Lys Arg Leu Arg Leu Asp Ser Asn Ala Leu Val Cys
 145                 150                 155                 160
 Asp Cys Asp Leu Met Trp Leu Gly Glu Leu Leu Gln Gly Phe Ala Gln
                 165                 170                 175    
 His Gly His Thr Gln Ala Ala Ala Thr Cys Glu Tyr Pro Arg Arg Leu
             180                 185                 190        
 His Gly Arg Ala Val Ala Ser Val Thr Val Glu Glu Phe Asn Cys Gln
         195                 200                 205            
 Ser Pro Arg Ile Thr Phe Glu Pro Gln Asp Val Glu Val Pro Ser Gly
     210                 215                 220                
 Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys Pro Glu
 225                 230                 235                 240
 Ile Ile Trp Ile His Asn Asn His Ser Leu Asp Leu Glu Asp Asp Thr
                 245                 250                 255    
 Arg Leu Asn Val Phe Asp Asp Gly Thr Leu Met Ile Arg Asn Thr Arg
             260                 265                 270        
 Glu Ser Asp Gln Gly Val Tyr Gln Cys Met Ala Arg Asn Ser Ala Gly
         275                 280                 285            
 Glu Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu Pro Ala
     290                 295                 300                
 Lys Pro Gly Phe Val Ile Gln Pro Gln Asp Thr Glu Val Leu Thr Gly
 305                 310                 315                 320
 Thr Ser Thr Thr Leu Glu Cys Met Ala Thr Gly His Pro His Pro Leu
                 325                 330                 335    
 Ile Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser Arg His
             340                 345                 350        
 Val Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln Arg Asp
         355                 360                 365            
 His Gly Arg Phe Thr Cys His Ala Asn Asn Ser His Gly Thr Val Gln
     370                 375                 380                
 Ala Ala Ala Asn Ile Ile Val Gln Ala Pro Pro Gln Phe Thr Val Thr
 385                 390                 395                 400
 Pro Lys Asp Gln Val Val Leu Glu Glu His Ala Val Glu Trp Leu Cys
                 405                 410                 415    
 Glu Ala Asp Gly Asn Pro Pro Pro Val Ile Val Trp Thr Lys Thr Gly
             420                 425                 430        
 Ile Arg Thr Ser Ala Gly Gly Gln Leu Pro Val Glu Gly Gln His Thr
         435                 440                 445            
 Val Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala Gln His Asp
     450                 455                 460                
 Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly Val Lys Lys
 465                 470                 475                 480
 Val Ser Val Gln Leu Thr Val Lys Pro Lys Gly Pro Ser Ser Asn Thr
                 485                 490                 495    
 Lys Thr Ala Gly Lys Ala Pro Leu Ile Pro Cys Cys Val Phe Arg Pro
             500                 505                 510        
 Phe Leu Val Ser Ala Leu Ala Val Phe Thr Gln Leu Pro Gln Asp Thr
         515                 520                 525            
 Ser Val Glu Val Gly Lys Asn Ile Asn Ile Ser Cys His Ala Gln Gly
     530                 535                 540                
 Glu Pro Gln Pro Ile Ile Thr Trp Asn Lys Glu Gly Val Lys Ile Thr
 545                 550                 555                 560
 Glu Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr Ile Tyr
                 565                 570                 575    
 Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala Arg Asn
             580                 585                 590        
 Ser Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr Gly Cys
         595                 600                 605            
 Asp Gln Tyr Trp Gly Leu Gly Thr Ser Val Ile Gly Ser Ser Asn Leu
     610                 615                 620                
 Ser Glu Glu His Gly Phe Ile Leu Lys Ala Leu Gly Leu Gly Thr Pro
 625                 630                 635                 640
 Gly Leu Ala Ile Gln Gly Arg Gln Ala Gly Asp Asp Phe Val Glu Ser
                 645                 650                 655    
 Ser Ile Leu Asp Ala Val Gln Arg Val Asp Ser Ala Ile Asn Ser Thr
             660                 665                 670        
 Arg Arg His Leu Phe Ser Gln Lys Pro His Thr Ser Ser Asp Leu Leu
         675                 680                 685            
 Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile Val Glu Met Ala Arg
     690                 695                 700                
 Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu Ile Arg Glu Arg Val
 705                 710                 715                 720
 Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr Asn
                 725                 730                 735    
 Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser Gly
             740                 745                 750        
 Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe His
         755                 760                 765            
 Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn Asn Leu Gln Gln Pro
     770                 775                 780                
 Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro Ala
 785                 790                 795                 800
 Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro Val Gly
                 805                 810                 815    
 Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val Ala Thr Val Trp Ala
             820                 825                 830        
 Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr Thr Arg Met Leu Met
         835                 840                 845            
 His Trp Gly Trp Phe Leu Glu His Asp Leu Asp His Thr Val Pro Ala
     850                 855                 860                
 Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser Val Cys
 865                 870                 875                 880
 Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr Arg His Ala Asp Pro
                 885                 890                 895    
 Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala Arg Ser Ser Pro Ala
             900                 905                 910        
 Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp Ser Val Tyr Ala Arg
         915                 920                 925            
 Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val Tyr
     930                 935                 940                
 Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser Val Pro
 945                 950                 955                 960
 Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys Pro
                 965                 970                 975    
 Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln Glu
             980                 985                 990        
 Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His Arg Ala Asn Glu His
         995                1000                1005            
 Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe Arg Glu His Asn Arg
    1010                1015                1020                
 Val Ala Thr Glu Leu Ser Ala Leu Asn Pro His Trp Glu Gly Asn Thr
1025                1030                1035                1040
 Val Tyr Gln Glu Ala Arg Lys Ile Val Gly Ala Glu Leu Gln His Ile
                1045                1050                1055    
 Thr Tyr Ser His Trp Leu Pro Lys Val Leu Gly Asp Pro Gly Thr Arg
            1060                1065                1070        
 Met Leu Arg Gly Tyr Arg Gly Tyr Asn Pro Asn Val Asn Ala Gly Ile
        1075                1080                1085            
 Ile Asn Ser Phe Ala Thr Ala Ala Phe Arg Phe Gly His Thr Leu Ile
    1090                1095                1100                
 Asn Pro Ile Leu Tyr Arg Leu Asn Ala Thr Leu Gly Glu Ile Ser Glu
1105                1110                1115                1120
 Gly His Leu Pro Phe His Lys Ala Leu Phe Ser Pro Ser Arg Ile Ile
                1125                1130                1135    
 Lys Glu Gly Gly Ile Asp Pro Val Leu Arg Gly Leu Phe Gly Val Ala
            1140                1145                1150        
 Ala Lys Trp Arg Ala Pro Ser Tyr Leu Leu Ser Pro Glu Leu Thr Gln
        1155                1160                1165            
 Arg Leu Phe Ser Ala Ala Tyr Ser Ala Ala Val Asp Ser Ala Ala Thr
    1170                1175                1180                
 Ile Ile Gln Arg Gly Arg Asp His Gly Ile Pro Pro Tyr Val Asp Phe
1185                1190                1195                1200
 Arg Val Phe Cys Asn Leu Thr Ser Val Lys Asn Phe Glu Asp Leu Gln
                1205                1210                1215    
 Asn Glu Ile Lys Asp Ser Glu Ile Arg Gln Lys Leu Arg Lys Leu Tyr
            1220                1225                1230        
 Gly Ser Pro Gly Asp Ile Asp Leu Trp Pro Ala Leu Met Val Glu Asp
        1235                1240                1245            
 Leu Ile Pro Gly Thr Arg Val Gly Pro Thr Leu Met Cys Leu Phe Val
    1250                1255                1260                
 Thr Gln Phe Gln Arg Leu Arg Asp Gly Asp Arg Phe Trp Tyr Glu Asn
1265                1270                1275                1280
 Pro Gly Val Phe Thr Pro Ala Gln Leu Thr Gln Leu Lys Gln Ala Ser
                1285                1290                1295    
 Leu Ser Arg Val Leu Cys Asp Asn Gly Asp Ser Ile Gln Gln Val Gln
            1300                1305                1310        
 Ala Asp Val Phe Val Lys Ala Glu Tyr Pro Gln Asp Tyr Leu Asn Cys
        1315                1320                1325            
 Ser Glu Ile Pro Lys Val Asp Leu Arg Val Trp Gln Asp Cys Cys Ala
    1330                1335                1340                
 Asp Cys Arg Ser Arg Gly Gln Phe Arg Ala Val Thr Gln Glu Ser Gln
1345                1350                1355                1360
 Lys Lys Arg Ser Ala Gln Tyr Ser Tyr Pro Val Asp Lys Asp Met Glu
                1365                1370                1375    
 Leu Ser His Leu Arg Ser Arg Gln Gln Asp Lys Ile Tyr Val Gly Glu
            1380                1385                1390        
 Asp Ala Arg Asn Val Thr Val Leu Ala Lys Thr Lys Phe Ser Gln Asp
        1395                1400                1405            
 Phe Ser Thr Phe Ala Ala Glu Ile Gln Glu Thr Ile Thr Ala Leu Arg
    1410                1415                1420                
 Glu Gln Ile Asn Lys Leu Glu Ala Arg Leu Arg Gln Ala Gly Cys Thr
1425                1430                1435                1440
 Asp Val Arg Gly Val Pro Arg Lys Ala Glu Glu Arg Trp Met Lys Glu
                1445                1450                1455    
 Asp Cys Thr His Cys Ile Cys Glu Ser Gly Gln Val Thr Cys Val Val
            1460                1465                1470        
 Glu Ile Cys Pro Pro Ala Pro Cys Pro Ser Pro Glu Leu Val Lys Gly
        1475                1480                1485            
 Thr Cys Cys Pro Val Cys Arg Asp Arg Gly Met Pro Ser Asp Ser Pro
    1490                1495                1500                
 Glu Lys Arg
1505        



      <210> 909
      <211> 1538
      <212> PRT
      <213> Homo sapiens


      <400> 909
 Met Asp Ile Cys Arg Thr Cys Leu Arg Arg Arg Leu Thr Ile Cys Cys
   1               5                  10                  15    
 Ser Pro Ser Gly Cys Phe Phe Ala Trp Pro Ala Ala Asn Gly Ala Met
              20                  25                  30        
 Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly Trp
          35                  40                  45            
 Cys Leu Pro Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe Lys Ser
      50                  55                  60                
 Thr Val Arg Cys Met His Leu Met Leu Asp His Ile Pro Gln Val Pro
  65                  70                  75                  80
 Gln Gln Thr Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile
                  85                  90                  95    
 Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu Tyr Leu
             100                 105                 110        
 Tyr Lys Asn His Ile Arg Lys Ile Ser Arg Asn Ala Phe Glu Gly Leu
         115                 120                 125            
 Glu Asn Leu Leu Tyr Leu Tyr Ile His Phe Asn Gln Leu Glu Met Leu
     130                 135                 140                
 Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg Leu Phe Leu
 145                 150                 155                 160
 His Asn Asn Lys Leu Ser Lys Ile Pro Ala Gly Ser Phe Ser Asn Leu
                 165                 170                 175    
 Asp Ser Leu Lys Arg Leu Arg Leu Asp Ser Asn Ala Leu Val Cys Asp
             180                 185                 190        
 Cys Asp Leu Met Trp Leu Gly Glu Leu Leu Gln Gly Phe Ala Gln His
         195                 200                 205            
 Gly His Thr Gln Ala Ala Ala Thr Cys Glu Tyr Pro Arg Arg Leu His
     210                 215                 220                
 Gly Arg Ala Val Ala Ser Val Thr Val Glu Glu Phe Asn Cys Gln Ser
 225                 230                 235                 240
 Pro Arg Ile Thr Phe Glu Pro Gln Asp Val Glu Val Pro Ser Gly Asn
                 245                 250                 255    
 Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys Pro Glu Ile
             260                 265                 270        
 Ile Trp Ile His Asn Asn His Ser Leu Asp Leu Glu Asp Asp Thr Arg
         275                 280                 285            
 Leu Asn Val Phe Asp Asp Gly Thr Leu Met Ile Arg Asn Thr Arg Glu
     290                 295                 300                
 Ser Asp Gln Gly Val Tyr Gln Cys Met Ala Arg Asn Ser Ala Gly Glu
 305                 310                 315                 320
 Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu Pro Ala Lys
                 325                 330                 335    
 Pro Gly Phe Val Ile Gln Pro Gln Asp Thr Glu Val Leu Thr Gly Thr
             340                 345                 350        
 Ser Thr Thr Leu Glu Cys Met Ala Thr Gly His Pro His Pro Leu Ile
         355                 360                 365            
 Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser Arg His Val
     370                 375                 380                
 Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln Arg Asp His
 385                 390                 395                 400
 Gly Arg Phe Thr Cys His Ala Asn Asn Ser His Gly Thr Val Gln Ala
                 405                 410                 415    
 Ala Ala Asn Ile Ile Val Gln Ala Pro Pro Gln Phe Thr Val Thr Pro
             420                 425                 430        
 Lys Asp Gln Val Val Leu Glu Glu His Ala Val Glu Trp Leu Cys Glu
         435                 440                 445            
 Ala Asp Gly Asn Pro Pro Pro Val Ile Val Trp Thr Lys Thr Gly Ile
     450                 455                 460                
 Arg Thr Ser Ala Gly Gly Gln Leu Pro Val Glu Gly Gln His Thr Val
 465                 470                 475                 480
 Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala Gln His Asp Gln
                 485                 490                 495    
 Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly Val Lys Lys Val
             500                 505                 510        
 Ser Val Gln Leu Thr Val Lys Pro Lys Gly Pro Ser Ser Asn Thr Lys
         515                 520                 525            
 Thr Ala Gly Lys Ala Pro Leu Ile Pro Cys Cys Val Phe Arg Pro Phe
     530                 535                 540                
 Leu Val Ser Ala Leu Ala Val Phe Thr Gln Leu Pro Gln Asp Thr Ser
 545                 550                 555                 560
 Val Glu Val Gly Lys Asn Ile Asn Ile Ser Cys His Ala Gln Gly Glu
                 565                 570                 575    
 Pro Gln Pro Ile Ile Thr Trp Asn Lys Glu Gly Val Lys Ile Thr Glu
             580                 585                 590        
 Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr Ile Tyr Asp
         595                 600                 605            
 Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala Arg Asn Ser
     610                 615                 620                
 Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr Gly Cys Asp
 625                 630                 635                 640
 Gln Tyr Trp Gly Leu Gly Thr Ser Val Ile Gly Ser Ser Asn Leu Ser
                 645                 650                 655    
 Glu Glu His Gly Phe Ile Leu Lys Ala Leu Gly Leu Gly Thr Pro Gly
             660                 665                 670        
 Leu Ala Ile Gln Gly Arg Gln Ala Gly Asp Asp Phe Val Glu Ser Ser
         675                 680                 685            
 Ile Leu Asp Ala Val Gln Arg Val Asp Ser Ala Ile Asn Ser Thr Arg
     690                 695                 700                
 Arg His Leu Phe Ser Gln Lys Pro His Thr Ser Ser Asp Leu Leu Ala
 705                 710                 715                 720
 Gln Phe His Tyr Pro Arg Asp Pro Leu Ile Val Glu Met Ala Arg Ala
                 725                 730                 735    
 Gly Glu Ile Phe Glu His Thr Leu Gln Leu Ile Arg Glu Arg Val Lys
             740                 745                 750        
 Gln Gly Leu Thr Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr Asn Asp
         755                 760                 765            
 Leu Val Ser Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser Gly Cys
     770                 775                 780                
 Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe His Ala
 785                 790                 795                 800
 Lys Tyr Arg Ala His Asp Gly Thr Cys Asn Asn Leu Gln Gln Pro Thr
                 805                 810                 815    
 Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro Ala Tyr
             820                 825                 830        
 Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro Val Gly Ser
         835                 840                 845            
 Arg Gln Pro Leu Pro Pro Pro Arg Leu Val Ala Thr Val Trp Ala Arg
     850                 855                 860                
 Ala Ala Ala Val Thr Pro Asp His Ser Tyr Thr Arg Met Leu Met His
 865                 870                 875                 880
 Trp Gly Trp Phe Leu Glu His Asp Leu Asp His Thr Val Pro Ala Leu
                 885                 890                 895    
 Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser Val Cys Thr
             900                 905                 910        
 Asn Asp Pro Pro Cys Phe Pro Met Asn Thr Arg His Ala Asp Pro Arg
         915                 920                 925            
 Gly Thr His Ala Pro Cys Met Leu Phe Ala Arg Ser Ser Pro Ala Cys
     930                 935                 940                
 Ala Ser Gly Arg Pro Ser Ala Thr Val Asp Ser Val Tyr Ala Arg Glu
 945                 950                 955                 960
 Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val Tyr Gly
                 965                 970                 975    
 Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser Val Pro Arg
             980                 985                 990        
 Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys Pro Leu
         995                1000                1005            
 Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln Glu Gln
    1010                1015                1020                
 Glu Ser Pro Cys Phe Leu Ala Gly Asp His Arg Ala Asn Glu His Leu
1025                1030                1035                1040
 Ala Leu Ala Ala Met His Thr Leu Trp Phe Arg Glu His Asn Arg Val
                1045                1050                1055    
 Ala Thr Glu Leu Ser Ala Leu Asn Pro His Trp Glu Gly Asn Thr Val
            1060                1065                1070        
 Tyr Gln Glu Ala Arg Lys Ile Val Gly Ala Glu Leu Gln His Ile Thr
        1075                1080                1085            
 Tyr Ser His Trp Leu Pro Lys Val Leu Gly Asp Pro Gly Thr Arg Met
    1090                1095                1100                
 Leu Arg Gly Tyr Arg Gly Tyr Asn Pro Asn Val Asn Ala Gly Ile Ile
1105                1110                1115                1120
 Asn Ser Phe Ala Thr Ala Ala Phe Arg Phe Gly His Thr Leu Ile Asn
                1125                1130                1135    
 Pro Ile Leu Tyr Arg Leu Asn Ala Thr Leu Gly Glu Ile Ser Glu Gly
            1140                1145                1150        
 His Leu Pro Phe His Lys Ala Leu Phe Ser Pro Ser Arg Ile Ile Lys
        1155                1160                1165            
 Glu Gly Gly Ile Asp Pro Val Leu Arg Gly Leu Phe Gly Val Ala Ala
    1170                1175                1180                
 Lys Trp Arg Ala Pro Ser Tyr Leu Leu Ser Pro Glu Leu Thr Gln Arg
1185                1190                1195                1200
 Leu Phe Ser Ala Ala Tyr Ser Ala Ala Val Asp Ser Ala Ala Thr Ile
                1205                1210                1215    
 Ile Gln Arg Gly Arg Asp His Gly Ile Pro Pro Tyr Val Asp Phe Arg
            1220                1225                1230        
 Val Phe Cys Asn Leu Thr Ser Val Lys Asn Phe Glu Asp Leu Gln Asn
        1235                1240                1245            
 Glu Ile Lys Asp Ser Glu Ile Arg Gln Lys Leu Arg Lys Leu Tyr Gly
    1250                1255                1260                
 Ser Pro Gly Asp Ile Asp Leu Trp Pro Ala Leu Met Val Glu Asp Leu
1265                1270                1275                1280
 Ile Pro Gly Thr Arg Val Gly Pro Thr Leu Met Cys Leu Phe Val Thr
                1285                1290                1295    
 Gln Phe Gln Arg Leu Arg Asp Gly Asp Arg Phe Trp Tyr Glu Asn Pro
            1300                1305                1310        
 Gly Val Phe Thr Pro Ala Gln Leu Thr Gln Leu Lys Gln Ala Ser Leu
        1315                1320                1325            
 Ser Arg Val Leu Cys Asp Asn Gly Asp Ser Ile Gln Gln Val Gln Ala
    1330                1335                1340                
 Asp Val Phe Val Lys Ala Glu Tyr Pro Gln Asp Tyr Leu Asn Cys Ser
1345                1350                1355                1360
 Glu Ile Pro Lys Val Asp Leu Arg Val Trp Gln Asp Cys Cys Ala Asp
                1365                1370                1375    
 Cys Arg Ser Arg Gly Gln Phe Arg Ala Val Thr Gln Glu Ser Gln Lys
            1380                1385                1390        
 Lys Arg Ser Ala Gln Tyr Ser Tyr Pro Val Asp Lys Asp Met Glu Leu
        1395                1400                1405            
 Ser His Leu Arg Ser Arg Gln Gln Asp Lys Ile Tyr Val Gly Glu Asp
    1410                1415                1420                
 Ala Arg Asn Val Thr Val Leu Ala Lys Thr Lys Phe Ser Gln Asp Phe
1425                1430                1435                1440
 Ser Thr Phe Ala Ala Glu Ile Gln Glu Thr Ile Thr Ala Leu Arg Glu
                1445                1450                1455    
 Gln Ile Asn Lys Leu Glu Ala Arg Leu Arg Gln Ala Gly Cys Thr Asp
            1460                1465                1470        
 Val Arg Gly Val Pro Arg Lys Ala Glu Glu Arg Trp Met Lys Glu Asp
        1475                1480                1485            
 Cys Thr His Cys Ile Cys Glu Ser Gly Gln Val Thr Cys Val Val Glu
    1490                1495                1500                
 Ile Cys Pro Pro Ala Pro Cys Pro Ser Pro Glu Leu Val Lys Gly Thr
1505                1510                1515                1520
 Cys Cys Pro Val Cys Arg Asp Arg Gly Met Pro Ser Asp Ser Pro Glu
                1525                1530                1535    
 Lys Arg
        



      <210> 910
      <211> 1400
      <212> PRT
      <213> Homo sapiens


      <400> 910
 Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly
   1               5                  10                  15    
 Trp Cys Leu Pro Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe Lys
              20                  25                  30        
 Ser Thr Val Arg Cys Met His Leu Met Leu Asp His Ile Pro Gln Val
          35                  40                  45            
 Pro Gln Gln Thr Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu
      50                  55                  60                
 Ile Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu Leu
  65                  70                  75                  80
 Leu Asn Asn Asn His Ile Arg Lys Ile Ser Arg Asn Ala Phe Glu Gly
                  85                  90                  95    
 Leu Glu Asn Leu Leu Tyr Leu Tyr Leu Tyr Lys Asn Glu Ile His Ala
             100                 105                 110        
 Leu Asp Lys Gln Thr Phe Lys Gly Leu Ile Ser Leu Glu His Leu Tyr
         115                 120                 125            
 Ile His Phe Asn Gln Leu Glu Met Leu Gln Pro Glu Thr Phe Gly Asp
     130                 135                 140                
 Leu Leu Arg Leu Glu Arg Leu Asp Glu Ala His Leu Ile Met Val Asp
 145                 150                 155                 160
 Lys Leu Phe Asp Val Leu Leu Asp Ser Val Cys Gln Tyr Phe Ile Glu
                 165                 170                 175    
 Asp Phe Cys Ile Asp Val His Gln Glu Ser Pro Arg Ile Thr Phe Glu
             180                 185                 190        
 Pro Gln Asp Val Glu Val Pro Ser Gly Asn Thr Val Tyr Phe Thr Cys
         195                 200                 205            
 Arg Ala Glu Gly Asn Pro Lys Pro Glu Ile Ile Trp Ile His Asn Asn
     210                 215                 220                
 His Ser Leu Asp Leu Glu Asp Asp Thr Arg Leu Asn Val Phe Asp Asp
 225                 230                 235                 240
 Gly Thr Leu Met Ile Arg Asn Thr Arg Glu Ser Asp Gln Gly Val Tyr
                 245                 250                 255    
 Gln Cys Met Ala Arg Asn Ser Ala Gly Glu Ala Lys Thr Gln Ser Ala
             260                 265                 270        
 Met Leu Arg Tyr Ser Ser Leu Pro Ala Lys Pro Ser Phe Val Ile Gln
         275                 280                 285            
 Pro Gln Asp Thr Glu Val Leu Ile Gly Thr Ser Thr Thr Leu Glu Cys
     290                 295                 300                
 Met Ala Thr Gly His Pro His Pro Leu Ile Thr Trp Thr Arg Asp Asn
 305                 310                 315                 320
 Gly Leu Glu Leu Asp Gly Ser Arg His Val Ala Thr Ser Ser Gly Leu
                 325                 330                 335    
 Tyr Leu Gln Asn Ile Thr Gln Arg Asp His Gly Arg Phe Thr Cys His
             340                 345                 350        
 Ala Asn Asn Ser His Gly Thr Val Gln Ala Ala Ala Asn Ile Ile Val
         355                 360                 365            
 Gln Ala Pro Pro Gln Phe Thr Val Thr Pro Lys Asp Gln Val Val Leu
     370                 375                 380                
 Glu Glu His Ala Val Glu Trp Leu Cys Glu Ala Asp Gly Asn Pro Pro
 385                 390                 395                 400
 Pro Val Ile Val Trp Thr Lys Thr Gly Ile Arg Thr Ser Ala Gly Gly
                 405                 410                 415    
 Gln Leu Pro Val Glu Gly Gln His Thr Val Leu Ser Ser Gly Thr Leu
             420                 425                 430        
 Arg Ile Asp Arg Ala Ala Gln His Asp Gln Gly Gln Tyr Glu Cys Gln
         435                 440                 445            
 Ala Val Ser Ser Leu Gly Val Lys Lys Val Ser Val Gln Leu Thr Val
     450                 455                 460                
 Lys Pro Lys Gly Pro Phe Met Gln Met Lys Asp Ser Asn Leu Leu Ser
 465                 470                 475                 480
 Ser Asp Trp Leu Val Gln Val Ser Ser Glu Gly Leu Glu Val Lys Lys
                 485                 490                 495    
 Glu Gly Val Gln Ile Thr Glu Ser Gly Lys Phe His Val Asp Asp Glu
             500                 505                 510        
 Gly Thr Leu Thr Ile Tyr Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr
         515                 520                 525            
 Glu Cys Val Ala Arg Asn Ser Phe Gly Leu Ala Val Thr Asn Met Phe
     530                 535                 540                
 Leu Thr Val Thr Val Ser Glu Lys Thr Val Glu Leu Ser Arg Ala Met
 545                 550                 555                 560
 Asn Trp Phe Pro Cys Leu Met Met Gln Ser Asp Glu Lys Pro His Thr
                 565                 570                 575    
 Ser Ser Asp Leu Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile
             580                 585                 590        
 Val Glu Met Ala Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu
         595                 600                 605            
 Ile Arg Glu Arg Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys
     610                 615                 620                
 Glu Phe Arg Tyr Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile
 625                 630                 635                 640
 Ala Asn Leu Ser Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser
                 645                 650                 655    
 Asn Arg Cys Phe His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn
             660                 665                 670        
 Asn Leu Gln Gln Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg
         675                 680                 685            
 Leu Leu Gln Pro Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu
     690                 695                 700                
 Gly Leu Pro Val Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val
 705                 710                 715                 720
 Ala Thr Val Trp Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr
                 725                 730                 735    
 Thr Arg Met Leu Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp
             740                 745                 750        
 His Thr Val Pro Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro
         755                 760                 765            
 Cys Ser Ser Val Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr
     770                 775                 780                
 Arg His Ala Asp Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala
 785                 790                 795                 800
 Arg Ser Ser Pro Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp
                 805                 810                 815    
 Ser Val Tyr Ala Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp
             820                 825                 830        
 Gly Ser Asn Val Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg
         835                 840                 845            
 Asp Pro Ser Val Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro
     850                 855                 860                
 Pro Ser Gly Lys Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu
 865                 870                 875                 880
 Cys Ala Arg Gln Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His
                 885                 890                 895    
 Arg Ala Asn Glu His Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe
             900                 905                 910        
 Arg Glu His Asn Arg Val Ala Thr Glu Leu Ser Ala Leu Asn Pro His
         915                 920                 925            
 Trp Glu Gly Asn Thr Val Tyr Gln Glu Ala Arg Lys Ile Val Gly Ala
     930                 935                 940                
 Glu Leu Gln His Ile Thr Tyr Ser His Trp Leu Pro Lys Val Leu Gly
 945                 950                 955                 960
 Asp Pro Gly Thr Arg Met Leu Arg Gly Tyr Arg Gly Tyr Asn Pro Asn
                 965                 970                 975    
 Val Asn Ala Gly Ile Ile Asn Ser Phe Ala Thr Ala Ala Phe Arg Phe
             980                 985                 990        
 Gly His Thr Leu Ile Asn Pro Ile Leu Tyr Arg Leu Asn Ala Thr Leu
         995                1000                1005            
 Gly Glu Ile Ser Glu Gly His Leu Pro Phe His Lys Ala Leu Phe Ser
    1010                1015                1020                
 Pro Ser Arg Ile Ile Lys Glu Gly Gly Ile Asp Pro Val Leu Arg Gly
1025                1030                1035                1040
 Leu Phe Gly Val Ala Ala Lys Trp Arg Ala Pro Ser Tyr Leu Leu Ser
                1045                1050                1055    
 Pro Glu Leu Thr Gln Arg Leu Phe Ser Ala Ala Tyr Ser Ala Ala Val
            1060                1065                1070        
 Asp Ser Ala Ala Thr Ile Ile Gln Arg Gly Arg Asp His Gly Ile Pro
        1075                1080                1085            
 Pro Tyr Val Asp Phe Arg Val Phe Cys Asn Leu Thr Ser Val Lys Asn
    1090                1095                1100                
 Phe Glu Asp Leu Gln Asn Glu Ile Lys Asp Ser Glu Ile Arg Gln Lys
1105                1110                1115                1120
 Leu Arg Lys Leu Tyr Gly Ser Pro Gly Asp Ile Asp Leu Trp Pro Ala
                1125                1130                1135    
 Leu Met Val Glu Asp Leu Ile Pro Gly Thr Arg Val Gly Pro Thr Leu
            1140                1145                1150        
 Met Cys Leu Phe Val Thr Gln Phe Gln Arg Leu Arg Asp Gly Asp Arg
        1155                1160                1165            
 Phe Trp Tyr Glu Asn Pro Gly Val Phe Thr Pro Ala Gln Leu Thr Gln
    1170                1175                1180                
 Leu Lys Gln Ala Ser Leu Ser Arg Val Leu Cys Asp Asn Gly Asp Ser
1185                1190                1195                1200
 Ile Gln Gln Val Gln Ala Asp Val Phe Val Lys Ala Glu Tyr Pro Gln
                1205                1210                1215    
 Asp Tyr Leu Asn Cys Ser Glu Ile Pro Lys Val Asp Leu Arg Val Trp
            1220                1225                1230        
 Gln Asp Cys Cys Ala Asp Cys Arg Ser Arg Gly Gln Phe Arg Ala Val
        1235                1240                1245            
 Thr Gln Glu Ser Gln Lys Lys Arg Ser Ala Gln Tyr Ser Tyr Pro Val
    1250                1255                1260                
 Asp Lys Asp Met Glu Leu Ser His Leu Arg Ser Arg Gln Gln Asp Lys
1265                1270                1275                1280
 Ile Tyr Val Gly Glu Asp Ala Arg Asn Val Thr Val Leu Ala Lys Thr
                1285                1290                1295    
 Lys Phe Ser Gln Asp Phe Ser Thr Phe Ala Ala Glu Ile Gln Glu Thr
            1300                1305                1310        
 Ile Thr Ala Leu Arg Glu Gln Ile Asn Lys Leu Glu Ala Arg Leu Arg
        1315                1320                1325            
 Gln Ala Gly Cys Thr Asp Val Arg Gly Val Pro Arg Lys Ala Glu Glu
    1330                1335                1340                
 Arg Trp Met Lys Glu Asp Cys Thr His Cys Ile Cys Glu Ser Gly Gln
1345                1350                1355                1360
 Val Thr Cys Val Val Glu Ile Cys Pro Pro Ala Pro Cys Pro Ser Pro
                1365                1370                1375    
 Glu Leu Val Lys Gly Thr Cys Cys Pro Val Cys Arg Asp Arg Gly Met
            1380                1385                1390        
 Pro Ser Asp Ser Pro Glu Lys Arg
        1395                1400



      <210> 911
      <211> 1083
      <212> PRT
      <213> Homo sapiens


      <400> 911
 Met Pro Leu His Ser Ser Leu Gly Asn Arg Pro Gly His Ser Glu Glu
   1               5                  10                  15    
 Val Leu Pro Gly Asn Pro Val Arg Pro Asp Val Arg Val Cys Val Pro
              20                  25                  30        
 Pro Gly Tyr Ser Gly Glu Leu Cys Glu Val Asp Glu Asp Glu Cys Ala
          35                  40                  45            
 Ser Ser Pro Cys Gln His Gly Gly Arg Cys Leu Gln Arg Ser Asp Pro
      50                  55                  60                
 Ala Leu Tyr Gly Gly Val Gln Ala Ala Phe Pro Gly Ala Phe Ser Phe
  65                  70                  75                  80
 Arg His Ala Ala Gly Phe Leu Cys His Cys Pro Pro Gly Phe Glu Gly
                  85                  90                  95    
 Ala Asp Cys Gly Val Glu Val Asp Glu Cys Ala Ser Arg Pro Cys Leu
             100                 105                 110        
 Asn Gly Gly His Cys Gln Asp Leu Pro Asn Gly Phe Gln Cys His Cys
         115                 120                 125            
 Pro Asp Gly Tyr Ala Gly Val Trp Gly Gly Val Gly Pro Gly Thr Ile
     130                 135                 140                
 Arg Ile Gly Gly Pro Gln Thr Leu Leu Asn Leu Gly Phe Val Ser Pro
 145                 150                 155                 160
 Lys Gly Pro Thr Cys Glu Glu Asp Val Asp Glu Cys Leu Ser Asp Pro
                 165                 170                 175    
 Cys Leu His Gly Gly Thr Cys Ser Asp Thr Val Ala Gly Tyr Ile Cys
             180                 185                 190        
 Arg Cys Pro Glu Thr Trp Gly Gly Arg Asp Cys Ser Val Gln Leu Thr
         195                 200                 205            
 Gly Cys Gln Gly His Thr Cys Pro Leu Ala Ala Thr Cys Ile Pro Ile
     210                 215                 220                
 Phe Glu Ser Gly Val His Ser Tyr Val Cys His Cys Pro Pro Gly Thr
 225                 230                 235                 240
 His Gly Pro Phe Cys Gly Gln Asn Thr Thr Phe Ser Val Met Ala Gly
                 245                 250                 255    
 Ser Pro Ile Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly Leu Ala
             260                 265                 270        
 Leu Arg Phe Arg Thr Thr Leu Pro Ala Gly Thr Leu Ala Thr Arg Asn
         275                 280                 285            
 Asp Thr Lys Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Thr Leu Gln
     290                 295                 300                
 Ala Thr Leu Trp Ser Tyr Ser Thr Thr Val Leu Val Leu Arg Leu Pro
 305                 310                 315                 320
 Asp Leu Ala Leu Asn Asp Gly His Trp His Gln Val Glu Val Val Leu
                 325                 330                 335    
 His Leu Ala Thr Leu Glu Leu Arg Leu Trp His Glu Gly Cys Pro Ala
             340                 345                 350        
 Arg Leu Cys Val Ala Ser Gly Pro Val Ala Leu Ala Ser Thr Ala Ser
         355                 360                 365            
 Ala Thr Pro Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly Asp Ala
     370                 375                 380                
 Thr Phe Ala Gly Cys Leu Gln Asp Val Arg Val Asp Gly His Leu Leu
 385                 390                 395                 400
 Leu Pro Glu Asp Leu Glu Ile Pro Ala Ala Thr Phe Gly Leu Gly Gly
                 405                 410                 415    
 Ala Pro Ser Ser Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro Asn
             420                 425                 430        
 Leu Thr Val Ser Phe Leu Leu Arg Thr Arg Glu Ser Ala Gly Leu Leu
         435                 440                 445            
 Leu Gln Phe Ala Asn Asp Ser Ala Ala Gly Leu Thr Val Phe Leu Ser
     450                 455                 460                
 Glu Gly Arg Ile Arg Ala Glu Ala Pro Gly Ser Pro Ala Val Val Leu
 465                 470                 475                 480
 Pro Gly Arg Trp Asp Asp Gly Leu Arg His Leu Val Met Leu Ser Phe
                 485                 490                 495    
 Gly Pro Asp Gln Leu Gln Asp Leu Gly Gln His Val His Val Gly Gly
             500                 505                 510        
 Arg Leu Leu Ala Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg Gly
         515                 520                 525            
 Cys Leu Gln Asp Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe Pro
     530                 535                 540                
 Leu Pro Leu Asp Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg Gln
 545                 550                 555                 560
 Ser Trp Asn Leu Thr Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro
                 565                 570                 575    
 Asp Pro Cys Phe Asn Gly Gly Thr Cys Leu Val Thr Trp Asn Asp Phe
             580                 585                 590        
 His Cys Thr Cys Pro Ala Asn Phe Thr Gly Pro Thr Cys Ala Gln Gln
         595                 600                 605            
 Leu Trp Cys Pro Gly Gln Pro Cys Leu Pro Pro Ala Thr Cys Glu Glu
     610                 615                 620                
 Val Pro Asp Gly Phe Val Cys Val Ala Glu Ala Thr Phe Arg Glu Gly
 625                 630                 635                 640
 Pro Pro Ala Ala Phe Ser Gly His Asn Ala Ser Ser Gly Arg Leu Leu
                 645                 650                 655    
 Gly Gly Leu Ser Leu Ala Phe Arg Thr Arg Asp Ser Glu Ala Trp Leu
             660                 665                 670        
 Leu Arg Ala Ala Ala Gly Ala Leu Glu Gly Val Trp Leu Ala Val Arg
         675                 680                 685            
 Asn Gly Ser Leu Ala Gly Gly Val Arg Gly Gly His Gly Leu Pro Gly
     690                 695                 700                
 Ala Val Leu Pro Ile Pro Gly Pro Arg Val Ala Asp Gly Ala Trp His
 705                 710                 715                 720
 Arg Val Arg Leu Ala Met Glu Arg Pro Ala Ala Ala Thr Ser Arg Trp
                 725                 730                 735    
 Leu Leu Trp Leu Asp Gly Ala Ala Thr Pro Val Ala Leu Arg Gly Leu
             740                 745                 750        
 Ala Ser Asp Leu Gly Phe Leu Gln Gly Pro Gly Ala Val Arg Ile Leu
         755                 760                 765            
 Leu Ala Glu Asn Phe Thr Gly Cys Leu Gly Arg Val Ala Leu Gly Gly
     770                 775                 780                
 Leu Pro Leu Pro Leu Ala Arg Pro Arg Pro Gly Ala Ala Pro Gly Ala
 785                 790                 795                 800
 Arg Glu His Phe Ala Ser Trp Pro Gly Thr Pro Ala Pro Ile Leu Gly
                 805                 810                 815    
 Cys Arg Gly Ala Pro Val Cys Ala Pro Ser Pro Cys Leu His Asp Gly
             820                 825                 830        
 Ala Cys Arg Asp Leu Phe Asp Ala Phe Ala Cys Ala Cys Gly Pro Gly
         835                 840                 845            
 Trp Glu Gly Pro Arg Cys Glu Ala His Val Asp Pro Cys His Ser Ala
     850                 855                 860                
 Pro Cys Ala Arg Gly Arg Cys His Thr His Pro Asp Gly Arg Phe Glu
 865                 870                 875                 880
 Cys Arg Cys Pro Pro Gly Phe Gly Gly Pro Arg Cys Arg Leu Pro Val
                 885                 890                 895    
 Pro Ser Lys Glu Cys Ser Leu Asn Val Thr Cys Leu Asp Gly Ser Pro
             900                 905                 910        
 Cys Glu Gly Gly Ser Pro Ala Ala Asn Cys Ser Cys Leu Glu Gly Leu
         915                 920                 925            
 Ala Gly Gln Arg Cys Gln Val Pro Thr Leu Pro Cys Glu Ala Asn Pro
     930                 935                 940                
 Cys Leu Asn Gly Gly Thr Cys Arg Ala Ala Gly Gly Val Ser Glu Cys
 945                 950                 955                 960
 Ile Cys Asn Ala Arg Phe Ser Gly Gln Phe Cys Glu Val Ala Lys Gly
                 965                 970                 975    
 Leu Pro Leu Pro Leu Pro Phe Pro Leu Leu Glu Val Ala Val Pro Ala
             980                 985                 990        
 Ala Cys Ala Cys Leu Leu Leu Leu Leu Leu Gly Leu Leu Ser Gly Ile
         995                1000                1005            
 Leu Ala Ala Arg Lys Arg Arg Gln Ser Glu Gly Thr Tyr Ser Pro Ser
    1010                1015                1020                
 Gln Gln Glu Val Ala Gly Ala Arg Leu Glu Met Asp Ser Val Leu Lys
1025                1030                1035                1040
 Gly Cys Cys Glu Asp Gln Arg Gly Arg Gln Trp Gly Lys Asn Leu Glu
                1045                1050                1055    
 Val Phe Asn Cys Arg Leu Met Gly Arg Thr Val Trp Val Ser Phe Trp
            1060                1065                1070        
 Asp Glu Asp Asp Arg Ala Thr Leu Leu Leu Pro
        1075                1080            



      <210> 912
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 912
 Met Asn Met Ala Tyr Gly Ser Leu His Leu Leu Gly Ser Ser Gly Pro
   1               5                  10                  15    
 Pro Thr Ser Ala Ser Arg Val Ala Arg Thr Thr Gly Met Ser His His
              20                  25                  30        
 Val Arg Leu Ile Phe Lys Lys Tyr Phe Phe Val Glu Thr Arg Ser His
          35                  40                  45            
 Tyr Val Ala Gln Thr Ser Leu Glu Phe Leu Asp Ser Ser Asn Pro Pro
      50                  55                  60                
 Thr Ser Ala Ser Gln Asn Ala Gly Ile Tyr Arg Tyr Glu Pro Leu Cys
  65                  70                  75                  80
 Pro Ala Asn Ala Asn Ile Phe Ile Ser
                  85                



      <210> 913
      <211> 631
      <212> PRT
      <213> Homo sapiens


      <400> 913
 Met Leu Pro Val Asp Gly Glu Glu Arg Lys Ser Glu Gly Ser Asp Thr
   1               5                  10                  15    
 Glu Gly Asp Arg Thr Ser Pro Cys Ala Val Ser Ser Ala Thr Leu Lys
              20                  25                  30        
 Asp Leu Glu Val Gly Gly Ser Gly Arg Arg Cys Ser Asp Pro Ala Gly
          35                  40                  45            
 Gln Pro Ser Asn Leu Leu Pro Gln Arg Gly Leu Gly Ala Pro Leu Pro
      50                  55                  60                
 Ala Glu Thr Ala His Thr Gln Pro Ser Pro Asn Asp Arg Ser Leu Tyr
  65                  70                  75                  80
 Leu Ser Pro Lys Ser Ser Ser Ala Ser Ser Ser Leu His Ala Arg Gln
                  85                  90                  95    
 Ser Pro Cys Gln Glu Gln Ala Ala Val Leu Asn Ser Arg Ser Ile Lys
             100                 105                 110        
 Ile Ser Arg Leu Asn Asp Thr Ile Lys Ser Leu Lys Gln Gln Lys Lys
         115                 120                 125            
 Gln Val Glu His Gln Leu Glu Glu Glu Lys Lys Ala Asn Asn Glu Lys
     130                 135                 140                
 Gln Lys Ala Glu Arg Glu Leu Glu Gly Gln Ile Gln Arg Leu Asn Thr
 145                 150                 155                 160
 Glu Lys Lys Lys Leu Asn Thr Asp Leu Tyr His Met Lys His Ser Leu
                 165                 170                 175    
 Arg Tyr Phe Glu Glu Glu Ser Lys Asp Leu Ala Gly Arg Leu Gln Arg
             180                 185                 190        
 Ser Ser Gln Arg Ile Gly Glu Leu Glu Trp Ser Leu Cys Ala Val Ala
         195                 200                 205            
 Ala Thr Gln Lys Lys Lys Pro Asp Gly Phe Ser Ser Arg Ser Lys Ala
     210                 215                 220                
 Leu Leu Lys Arg Gln Leu Glu Gln Ser Ile Arg Glu Gln Ile Leu Leu
 225                 230                 235                 240
 Lys Gly His Val Thr Gln Leu Lys Glu Ser Leu Lys Glu Val Gln Leu
                 245                 250                 255    
 Glu Arg Asp Gln Tyr Ala Glu Gln Ile Lys Gly Glu Arg Ala Gln Trp
             260                 265                 270        
 Gln Gln Arg Met Arg Lys Met Ser Gln Glu Val Cys Thr Leu Lys Glu
         275                 280                 285            
 Glu Lys Lys His Asp Thr His Arg Val Glu Glu Leu Glu Arg Ser Leu
     290                 295                 300                
 Ser Arg Leu Lys Asn Gln Met Ala Glu Pro Leu Pro Pro Asp Ala Pro
 305                 310                 315                 320
 Ala Val Ser Ser Glu Val Glu Leu Gln Asp Leu Arg Lys Glu Leu Glu
                 325                 330                 335    
 Arg Val Ala Gly Glu Leu Gln Ala Gln Val Glu Asn Asn Gln Cys Ile
             340                 345                 350        
 Ser Leu Leu Asn Arg Gly Gln Lys Glu Arg Leu Arg Glu Gln Glu Glu
         355                 360                 365            
 Arg Leu Gln Glu Gln Gln Glu Arg Leu Arg Glu Gln Glu Lys Arg Leu
     370                 375                 380                
 Gln Gln Leu Ala Glu Pro Gln Ser Asp Leu Glu Glu Leu Lys His Glu
 385                 390                 395                 400
 Asn Lys Ser Ala Leu Gln Leu Glu Gln Gln Val Lys Glu Leu Gln Glu
                 405                 410                 415    
 Lys Leu Gly Gln Val Met Glu Thr Leu Thr Ser Ala Glu Lys Glu Pro
             420                 425                 430        
 Glu Ala Ala Val Pro Ala Ser Gly Thr Gly Gly Glu Ser Ser Gly Leu
         435                 440                 445            
 Met Asp Leu Leu Glu Glu Lys Ala Asp Leu Arg Glu His Val Glu Lys
     450                 455                 460                
 Leu Glu Leu Gly Phe Ile Gln Tyr Arg Arg Glu Arg Cys His Gln Asn
 465                 470                 475                 480
 Val His Arg Leu Leu Thr Glu Pro Gly Asp Ser Ala Lys Asp Ala Ser
                 485                 490                 495    
 Pro Gly Gly Gly His His Gln Ala Gly Pro Gly Gln Gly Gly Glu Glu
             500                 505                 510        
 Gly Glu Ala Ala Gly Ala Ala Gly Asp Gly Val Ala Ala Cys Gly Ser
         515                 520                 525            
 Tyr Asn Glu Gly His Gly Lys Phe Leu Ala Ala Ala Arg Asn Pro Ala
     530                 535                 540                
 Ala Glu Pro Ser Pro Gly Ala Pro Ala Pro Gln Glu Leu Gly Ala Ala
 545                 550                 555                 560
 Asp Lys His Gly Asp Leu Cys Glu Ala Ser Leu Thr Asn Ser Val Glu
                 565                 570                 575    
 Pro Ala Gln Gly Glu Ala Arg Glu Gly Ser Ser Gln Asp Asn Pro Thr
             580                 585                 590        
 Ala Gln Pro Val Val Gln Leu Leu Gly Glu Met Gln Asp His Gln Glu
         595                 600                 605            
 His Pro Gly Leu Gly Ser Asn Cys Cys Val Pro Cys Phe Cys Trp Ala
     610                 615                 620                
 Trp Leu Pro Arg Arg Arg Arg
 625                 630    



      <210> 914
      <211> 381
      <212> PRT
      <213> Homo sapiens


      <400> 914
 Met Ala Ser Pro Pro Ala Cys Pro Ser Glu Glu Asp Glu Ser Leu Lys
   1               5                  10                  15    
 Gly Cys Glu Leu Tyr Val Gln Leu His Gly Ile Gln Gln Val Leu Lys
              20                  25                  30        
 Asp Cys Ile Val His Leu Cys Ile Ser Lys Pro Glu Arg Pro Met Lys
          35                  40                  45            
 Phe Leu Arg Glu His Phe Glu Lys Leu Glu Lys Glu Glu Asn Arg Gln
      50                  55                  60                
 Ile Leu Ala Arg Gln Lys Ser Asn Ser Gln Ser Asp Ser His Asp Glu
  65                  70                  75                  80
 Glu Val Ser Pro Thr Pro Pro Asn Pro Val Val Lys Ala Arg Arg Arg
                  85                  90                  95    
 Arg Gly Gly Val Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Val Ser
             100                 105                 110        
 Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Thr Ala Leu
         115                 120                 125            
 Ala Lys Ala Ile Ser Lys Asn Val Leu Phe Ala His Leu Asp Asp Asn
     130                 135                 140                
 Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Pro Val Thr His Ile Ala
 145                 150                 155                 160
 Gly Glu Thr Val Ile Gln Gln Gly Asn Glu Gly Asp Asn Phe Tyr Val
                 165                 170                 175    
 Val Asp Gln Gly Glu Val Asp Val Tyr Val Asn Gly Glu Trp Val Thr
             180                 185                 190        
 Asn Ile Ser Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly
         195                 200                 205            
 Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asp Leu Lys Leu Trp
     210                 215                 220                
 Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu
 225                 230                 235                 240
 Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu
                 245                 250                 255    
 Glu Ser Leu Glu Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu
             260                 265                 270        
 Pro Val Gln Phe Glu Asp Gly Glu Lys Ile Val Val Gln Gly Glu Pro
         275                 280                 285            
 Gly Asp Asp Phe Tyr Ile Ile Thr Glu Gly Thr Ala Ser Val Leu Gln
     290                 295                 300                
 Arg Arg Ser Pro Asn Glu Glu Tyr Val Glu Val Gly Arg Leu Gly Pro
 305                 310                 315                 320
 Ser Asp Tyr Phe Gly Glu Ile Ala Leu Leu Leu Asn Arg Pro Arg Ala
                 325                 330                 335    
 Ala Thr Val Val Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg
             340                 345                 350        
 Pro Arg Phe Glu Arg Val Leu Gly Pro Cys Ser Glu Ile Leu Lys Arg
         355                 360                 365            
 Asn Ile Gln Arg Tyr Asn Ser Phe Ile Ser Leu Thr Val
     370                 375                 380    



      <210> 915
      <211> 654
      <212> PRT
      <213> Homo sapiens


      <400> 915
 Met Thr Leu Ile Glu Pro Gly Gly Asp Asp His Lys Leu Thr Pro Ala
   1               5                  10                  15    
 Phe Leu Leu Cys Leu Cys Ile Gln His Ser Ala Thr His Phe Gln Pro
              20                  25                  30        
 Gly Thr Phe Gly Gln Leu Leu Leu Lys Ile Ala Arg Leu Ile Arg Glu
          35                  40                  45            
 Thr Val Trp Glu Lys Thr Lys Glu Leu Ala Glu Lys Gln Ala Gln Leu
      50                  55                  60                
 Gln Glu Pro Ile Ser Leu Ala Ser Cys Ala Met Ala Asp Leu Val Pro
  65                  70                  75                  80
 Asp Leu Gln Pro Ile Leu Phe Trp Met Ser Asn Ser Ile Glu Leu Leu
                  85                  90                  95    
 Tyr Phe Ile Gln Gln Lys Cys Pro Leu Tyr Met Gln Ser Met Glu Glu
             100                 105                 110        
 Gln Leu Asp Ile Thr Gly Ser Lys Glu Ser Leu Phe Ser Cys Thr Leu
         115                 120                 125            
 Thr Ala Ser Glu Glu Ala Met Ala Val Leu Glu Glu Val Val Leu Tyr
     130                 135                 140                
 Ala Phe Gln Gln Cys Val Tyr Tyr Val Ser Lys Ser Leu Tyr Ile Cys
 145                 150                 155                 160
 Leu Pro Ala Leu Leu Glu Cys Pro Pro Phe Gln Thr Glu Arg Arg Glu
                 165                 170                 175    
 Ser Trp Ser Ser Ala Pro Glu Leu Pro Glu Glu Leu Arg Arg Val Val
             180                 185                 190        
 Ser Val Tyr Gln Ala Ala Leu Asp Leu Leu Arg Gln Leu Gln Val His
         195                 200                 205            
 Pro Glu Val Ala Ser Gln Met Leu Ala Tyr Leu Phe Phe Phe Ser Gly
     210                 215                 220                
 Thr Leu Leu Leu Asn Gln Leu Leu Asp Arg Gly Pro Ser Leu Ser Cys
 225                 230                 235                 240
 Phe His Trp Pro Arg Gly Val Gln Ala Cys Ala Arg Leu Gln Gln Leu
                 245                 250                 255    
 Leu Glu Trp Met Arg Ser Ala Gly Phe Gly Ala Ala Gly Glu His Phe
             260                 265                 270        
 Phe Gln Lys Leu Ser Cys Thr Leu Asn Leu Leu Ala Thr Pro Arg Ala
         275                 280                 285            
 Gln Leu Ile Gln Met Ser Trp Thr Ala Leu Arg Ala Ala Phe Pro Ala
     290                 295                 300                
 Leu Ser Pro Ala Gln Leu His Arg Leu Leu Thr His Tyr Gln Leu Ala
 305                 310                 315                 320
 Ser Ala Met Gly Pro Met Ser Thr Trp Glu Pro Gly Ala Gln Asp Ser
                 325                 330                 335    
 Pro Glu Ala Phe Arg Ser Glu Asp Val Leu Glu Ser Tyr Glu Asn Pro
             340                 345                 350        
 Pro Pro Ile Val Leu Pro Ser Asp Gly Phe Gln Val Asp Leu Glu Ala
         355                 360                 365            
 Asn Cys Leu Asp Asp Ser Ile Tyr Gln His Leu Leu Tyr Val Arg His
     370                 375                 380                
 Phe Leu Trp Gly Leu Arg Ser Arg Ala Ser Pro Gly Ser Pro Gly Arg
 385                 390                 395                 400
 Pro Gly Ser Gly Ala Ser Gln Pro Val Cys Pro Glu Gly Met His His
                 405                 410                 415    
 Val Val Leu Asp Gly His Leu Glu Ala Pro Ser Cys Pro Leu Ala Pro
             420                 425                 430        
 Arg Asp Pro Gly Pro Ala Ala Arg Glu Val Ala Pro Glu Arg Thr Leu
         435                 440                 445            
 Pro Leu Arg Gly Ala Pro Trp Ala Gln Ala Pro Pro Gly Arg Gln Pro
     450                 455                 460                
 Gly Arg Gly Gly Ser Gln Ala Gly Pro Pro His Thr Asp Ser Ser Cys
 465                 470                 475                 480
 Leu Leu Thr Pro Pro Ser Thr Pro Leu Gly Pro Glu Pro Gly Asp Pro
                 485                 490                 495    
 Asp Trp Pro Glu Ser Gly Gly Pro Cys Gly Lys Ala Leu Pro Glu Arg
             500                 505                 510        
 Gln Arg Asn Gly Leu Ser Gly Leu Arg Gly Ala Ala Pro Glu Gly Asp
         515                 520                 525            
 Ser Ala Ala Leu Ala Glu Glu Ser Pro Pro Ala Pro Ser Ser Arg Ser
     530                 535                 540                
 Ser Ser Thr Glu Asp Phe Cys Tyr Val Phe Thr Val Glu Leu Glu Arg
 545                 550                 555                 560
 Gly Pro Ser Gly Leu Gly Met Gly Leu Ile Asp Gly Met His Thr His
                 565                 570                 575    
 Leu Gly Ala Pro Gly Leu Tyr Ile Gln Thr Leu Leu Pro Gly Ser Pro
             580                 585                 590        
 Ala Ala Ala Asp Gly Arg Leu Ser Leu Gly Asp Arg Ile Leu Glu Val
         595                 600                 605            
 Asn Gly Ser Ser Leu Leu Gly Leu Gly Tyr Leu Arg Ala Val Asp Leu
     610                 615                 620                
 Ile Arg His Gly Gly Lys Lys Met Arg Phe Leu Val Ala Lys Ser Asp
 625                 630                 635                 640
 Val Glu Thr Ala Lys Lys Ile His Phe Arg Thr Pro Pro Leu
                 645                 650                



      <210> 916
      <211> 647
      <212> PRT
      <213> Homo sapiens


      <400> 916
 Met Gly Lys Tyr Thr Val Arg Val Ala Thr Gly Asp Leu Leu Leu Ala
   1               5                  10                  15    
 Gly Ser Pro Asn Leu Val Gln Leu Trp Leu Val Gly Glu His Gly Glu
              20                  25                  30        
 Ala Asp Leu Gly Lys Gln Leu Pro Pro Val Trp Gly Lys Glu Ala Glu
          35                  40                  45            
 Phe Glu Ile Asp Val Pro Leu His Leu Gly Arg Leu Leu Met Val Lys
      50                  55                  60                
 Leu Arg Lys His Asn Val Leu Leu Ser Leu Asp Trp Phe Cys Lys Trp
  65                  70                  75                  80
 Ile Ser Val Gln Gly Pro Gly Thr Gln Gly Glu Ala Phe Phe Pro Cys
                  85                  90                  95    
 Tyr Arg Trp Val Gln Gly His Gly Ile Ile Cys Leu Pro Glu Gly Thr
             100                 105                 110        
 Ala Arg Thr Val Ser Asp Asp Pro Gln Asn Leu Phe Lys Lys Tyr Arg
         115                 120                 125            
 Glu Gln Glu Leu Glu Glu Arg Arg Lys Ala Ser Ser Arg Trp Gly Ser
     130                 135                 140                
 Trp Lys Asp Gly Leu Ile Leu Pro Ile Ala Gly Asn Arg Gln Pro Asp
 145                 150                 155                 160
 Leu Pro Arg Asp Glu Arg Phe Leu Glu Asp Lys Asp Leu Asp Phe Asn
                 165                 170                 175    
 Val Ser Leu Ala Lys Gly Asp Leu Ala Ile Lys Gly Thr Leu Asp Phe
             180                 185                 190        
 Ile Asn Cys Val Lys Arg Leu Glu Asp Phe Lys Lys Ile Phe Pro His
         195                 200                 205            
 Gly Lys Thr Val Leu Ala Glu Arg Val Tyr Asp Ser Trp Lys Asn Asp
     210                 215                 220                
 Ala Phe Phe Gly Tyr Gln Phe Leu Asn Gly Ala Asn Pro Met Leu Leu
 225                 230                 235                 240
 Arg Cys Ser Ser Arg Leu Pro Ala Cys Leu Val Leu Pro Pro Gly Met
                 245                 250                 255    
 Glu Asp Leu Lys Thr Gln Leu Glu Lys Glu Leu Gln Ala Gly Ser Leu
             260                 265                 270        
 Phe Glu Val Asp Phe Ser Leu Leu Asp Gly Val Lys Pro Asn Val Ile
         275                 280                 285            
 Ile Phe Lys Gln Gln Cys Val Ala Ala Pro Leu Val Met Leu Lys Leu
     290                 295                 300                
 Gln Pro Asp Gly Gly Leu Leu Pro Met Val Ile Gln Leu Gln Pro Pro
 305                 310                 315                 320
 His Gly Cys Pro Pro Pro Leu Leu Phe Leu Pro Ser His Pro Pro Met
                 325                 330                 335    
 Ala Trp Leu Leu Ala Lys Thr Trp Val Arg Ser Ser Asp Phe Gln Leu
             340                 345                 350        
 Gln Gln Leu Gln Ser His Leu Leu Arg Gly His Leu Ile Ala Glu Val
         355                 360                 365            
 Ile Ala Val Ala Thr Met Arg Ser Leu Pro Ser Leu His Pro Ile Tyr
     370                 375                 380                
 Lys Leu Leu Ile Pro His Phe Arg Tyr Thr Met Ala Ile Asn Thr Leu
 385                 390                 395                 400
 Ala Gln Ser Ser Leu Val Ser Glu Trp Gly Ile Phe Asp Leu Val Val
                 405                 410                 415    
 Ser Thr Gly Ser Gly Ser His Val Asp Ile Leu Gln Arg Ala Met Ala
             420                 425                 430        
 Cys Leu Thr Tyr His Ser Leu Cys Pro Pro Asp Asp Leu Ala Asp Arg
         435                 440                 445            
 Gly Leu Leu Asp Val Lys Ser Ser Phe Tyr Gly Asp Ala Ile Arg Leu
     450                 455                 460                
 Trp Gly Ile Ile Ser Arg Tyr Met Glu Gly Met Val Gly Leu Phe Tyr
 465                 470                 475                 480
 Asn Ser Asp Gln Ala Met Lys Asp Asp Leu Glu Leu Gln Ala Trp Cys
                 485                 490                 495    
 Arg Glu Met Thr Glu Thr Gly Leu Gln Arg Ala Gln Asp Gln Gly Phe
             500                 505                 510        
 Leu Ile Ser Leu Glu Ser Arg Ala Gln Leu Cys His Phe Val Thr Met
         515                 520                 525            
 Cys Ile Phe Thr Cys Thr Gly Gln His Ala Ser Asn His Leu Gly Gln
     530                 535                 540                
 Leu Asp Trp Tyr Ser Trp Ile Pro Asn Gly Pro Cys Thr Met Gln Lys
 545                 550                 555                 560
 Pro Pro Pro Ile Ser Lys Asp Val Thr Glu Lys Asp Ile Val Asp Leu
                 565                 570                 575    
 Leu Pro Asn Leu His Gln Ala Arg Met Gln Lys Thr Phe Thr Lys Phe
             580                 585                 590        
 Leu Gly Arg Arg Gln Pro Val Met Val Arg Ser Lys His Glu Glu Lys
         595                 600                 605            
 Tyr Phe Ser Gly Pro Glu Pro Gln Ala Val Leu Arg Gln Phe Gln Glu
     610                 615                 620                
 Glu Leu Ala Ser Met Asp Lys Glu Ile Glu Val Arg Asn Ala Val Leu
 625                 630                 635                 640
 Asp Leu Pro Cys Glu Tyr Leu
                 645        



      <210> 917
      <211> 293
      <212> PRT
      <213> Homo sapiens


      <400> 917
 Met Gly Lys Tyr Thr Val Arg Val Ala Thr Gly Asp Leu Leu Leu Ala
   1               5                  10                  15    
 Gly Ser Pro Asn Leu Val Gln Leu Trp Leu Val Gly Glu His Gly Glu
              20                  25                  30        
 Ala Asp Leu Gly Lys Gln Leu Pro Pro Val Trp Gly Lys Glu Ala Glu
          35                  40                  45            
 Phe Glu Ile Asp Val Pro Leu His Leu Gly Arg Leu Leu Met Val Lys
      50                  55                  60                
 Leu Arg Lys His Asn Val Leu Leu Ser Leu Asp Trp Phe Cys Lys Trp
  65                  70                  75                  80
 Ile Ser Val Gln Gly Pro Gly Thr Gln Gly Glu Ala Phe Phe Pro Cys
                  85                  90                  95    
 Tyr Arg Trp Val Gln Gly His Gly Ile Ile Cys Leu Pro Glu Gly Arg
             100                 105                 110        
 Trp Gly Ser Trp Lys Asp Gly Leu Ile Leu Pro Ile Ala Gly Asn Arg
         115                 120                 125            
 Gln Pro Asp Leu Pro Arg Asp Glu Arg Phe Leu Glu Asp Lys Asp Leu
     130                 135                 140                
 Asp Phe Asn Val Ser Leu Ala Lys Gly Leu Lys Asp Leu Ala Ile Lys
 145                 150                 155                 160
 Gly Thr Leu Asp Phe Ile Asn Cys Val Lys Arg Leu Glu Asp Phe Lys
                 165                 170                 175    
 Lys Ile Phe Pro His Gly Lys Thr Val Leu Ala Glu Arg Val Tyr Asp
             180                 185                 190        
 Ser Trp Lys Asn Asp Ala Phe Phe Gly Tyr Gln Phe Leu Asn Gly Ala
         195                 200                 205            
 Asn Pro Met Leu Leu Arg Cys Ser Ser Arg Leu Pro Ala Cys Leu Val
     210                 215                 220                
 Leu Pro Pro Gly Met Glu Asp Leu Lys Thr Gln Leu Glu Lys Glu Leu
 225                 230                 235                 240
 Gln Ala Gly Ser Leu Phe Glu Val Asp Phe Ser Leu Leu Asp Gly Val
                 245                 250                 255    
 Lys Pro Asn Val Ile Ile Phe Lys Gln Gln Cys Val Ala Ala Pro Leu
             260                 265                 270        
 Val Met Leu Lys Leu Gln Pro Asp Gly Gly Leu Leu Pro Met Val Ile
         275                 280                 285            
 Gln Leu Gln Pro Pro
     290            



      <210> 918
      <211> 322
      <212> PRT
      <213> Homo sapiens


      <400> 918
 Met Gly Lys Tyr Thr Val Arg Val Ala Thr Gly Asp Leu Leu Leu Ala
   1               5                  10                  15    
 Gly Ser Pro Asn Leu Val Gln Leu Trp Leu Val Gly Glu His Gly Glu
              20                  25                  30        
 Ala Asp Leu Gly Lys Gln Leu Pro Pro Val Trp Gly Lys Glu Ala Glu
          35                  40                  45            
 Phe Glu Ile Asp Val Pro Leu His Leu Gly Arg Leu Leu Met Val Lys
      50                  55                  60                
 Leu Arg Lys His Asn Val Leu Leu Ser Leu Asp Trp Phe Cys Lys Trp
  65                  70                  75                  80
 Ile Ser Val Gln Gly Pro Gly Thr Gln Gly Glu Ala Phe Phe Pro Cys
                  85                  90                  95    
 Tyr Arg Trp Val Gln Gly His Gly Ile Ile Cys Leu Pro Glu Gly Thr
             100                 105                 110        
 Ala Arg Thr Val Ser Asp Asp Pro Gln Asn Leu Phe Lys Lys Tyr Arg
         115                 120                 125            
 Glu Gln Glu Leu Glu Glu Arg Arg Lys Ala Ser Ser Arg Trp Gly Ser
     130                 135                 140                
 Trp Lys Asp Gly Leu Ile Leu Pro Ile Ala Gly Asn Arg Gln Pro Asp
 145                 150                 155                 160
 Leu Pro Arg Asp Glu Arg Phe Leu Glu Asp Lys Asp Leu Asp Phe Asn
                 165                 170                 175    
 Val Ser Leu Ala Lys Gly Leu Lys Asp Leu Ala Ile Lys Gly Thr Leu
             180                 185                 190        
 Asp Phe Ile Asn Cys Val Lys Arg Leu Glu Asp Phe Lys Lys Ile Phe
         195                 200                 205            
 Pro His Gly Lys Thr Val Leu Ala Glu Arg Val Tyr Asp Ser Trp Lys
     210                 215                 220                
 Asn Asp Ala Phe Phe Gly Tyr Gln Phe Leu Asn Gly Ala Asn Pro Met
 225                 230                 235                 240
 Leu Leu Arg Cys Ser Ser Arg Leu Pro Ala Cys Leu Val Leu Pro Pro
                 245                 250                 255    
 Gly Met Glu Asp Leu Lys Thr Gln Leu Glu Lys Glu Leu Gln Ala Gly
             260                 265                 270        
 Ser Leu Phe Glu Val Asp Phe Ser Leu Leu Asp Gly Val Lys Pro Asn
         275                 280                 285            
 Val Ile Ile Phe Lys Gln Gln Cys Val Ala Ala Pro Leu Val Met Leu
     290                 295                 300                
 Lys Leu Gln Pro Asp Gly Gly Leu Leu Pro Met Val Ile Gln Leu Gln
 305                 310                 315                 320
 Pro Pro
        



      <210> 919
      <211> 729
      <212> PRT
      <213> Homo sapiens


      <400> 919
 Met Phe Ile Leu Ser Thr Thr Thr Pro Phe Ala Thr Leu Val Gly Thr
   1               5                  10                  15    
 Tyr Val Ile Phe Ile Asn Ile Glu Thr Lys Lys Lys Thr Val Leu Gln
              20                  25                  30        
 Cys Ser Asn Gly Ile Val Gly Val Met Ala Thr Asn Ile Pro Cys Glu
          35                  40                  45            
 Val Val Ala Phe Ser Asp Arg Lys Leu Lys Pro Leu Ile Tyr Val Tyr
      50                  55                  60                
 Ser Phe Pro Gly Leu Thr Arg Arg Thr Lys Leu Lys Gly Asn Ile Leu
  65                  70                  75                  80
 Leu Asp Tyr Thr Leu Leu Ser Phe Ser Tyr Cys Gly Thr Tyr Leu Ala
                  85                  90                  95    
 Ser Tyr Ser Ser Leu Pro Glu Phe Glu Leu Ala Leu Trp Asn Trp Glu
             100                 105                 110        
 Ser Ser Ile Ile Leu Cys Lys Lys Ser Gln Pro Gly Met Asp Val Asn
         115                 120                 125            
 Gln Met Ser Phe Asn Pro Met Asn Trp Arg Gln Leu Cys Leu Ser Ser
     130                 135                 140                
 Pro Ser Thr Val Ser Val Trp Thr Ile Glu Arg Ser Asn Gln Glu His
 145                 150                 155                 160
 Cys Phe Arg Ala Arg Ser Val Lys Leu Pro Leu Glu Asp Gly Ser Phe
                 165                 170                 175    
 Phe Asn Glu Thr Asp Val Val Phe Pro Gln Ser Leu Pro Lys Asp Leu
             180                 185                 190        
 Ile Tyr Gly Pro Val Leu Pro Leu Ser Ala Ile Ala Gly Leu Val Gly
         195                 200                 205            
 Lys Glu Ala Glu Thr Phe Arg Pro Lys Asp Asp Leu Tyr Pro Leu Leu
     210                 215                 220                
 His Pro Thr Met His Cys Trp Thr Pro Thr Ser Asp Leu Tyr Ile Gly
 225                 230                 235                 240
 Cys Glu Glu Gly His Leu Leu Met Ile Asn Gly Asp Thr Leu Gln Val
                 245                 250                 255    
 Thr Val Leu Asn Lys Ile Glu Glu Glu Ser Pro Leu Glu Asp Arg Arg
             260                 265                 270        
 Asn Phe Ile Ser Pro Val Thr Leu Val Tyr Gln Lys Glu Gly Val Leu
         275                 280                 285            
 Ala Ser Gly Ile Asp Gly Phe Val Tyr Ser Phe Ile Ile Lys Asp Arg
     290                 295                 300                
 Ser Tyr Met Ile Glu Asp Phe Leu Glu Ile Glu Arg Pro Val Glu His
 305                 310                 315                 320
 Met Thr Phe Ser Pro Asn Tyr Thr Val Leu Leu Ile Gln Thr Asp Lys
                 325                 330                 335    
 Gly Ser Val Tyr Ile Tyr Thr Phe Gly Lys Glu Pro Thr Leu Asn Lys
             340                 345                 350        
 Val Leu Asp Ala Cys Asp Gly Lys Phe Gln Ala Ile Asp Phe Ile Thr
         355                 360                 365            
 Pro Gly Thr Gln Tyr Phe Met Thr Leu Thr Tyr Ser Gly Glu Ile Cys
     370                 375                 380                
 Val Trp Trp Leu Glu Asp Cys Ala Cys Val Ser Lys Ile Tyr Leu Asn
 385                 390                 395                 400
 Thr Leu Ala Thr Val Leu Ala Cys Cys Pro Ser Ser Leu Ser Ala Ala
                 405                 410                 415    
 Val Gly Thr Glu Asp Gly Ser Val Tyr Phe Ile Ser Val Tyr Asp Lys
             420                 425                 430        
 Glu Ser Pro Gln Val Val His Lys Ala Phe Leu Ser Glu Ser Ser Val
         435                 440                 445            
 Gln His Val Val Tyr Asp Gln Gln Gly Ile Phe Leu Leu Val Gly Thr
     450                 455                 460                
 Ala Glu Gly Lys Val Phe Ile Ile Asn Ala Asn Ser Ser Ser Ser Phe
 465                 470                 475                 480
 Gln Ile Ile Gly Phe Thr Glu Val Ala Lys Asp Ile Leu Gln Ile Ser
                 485                 490                 495    
 Thr Val Ser Leu Leu Glu Thr Asp Ile Val Glu Val Met Val Leu Ser
             500                 505                 510        
 Ser Leu Pro Glu Ala Gly Arg Ser Arg Leu Glu Met Phe Thr Leu Pro
         515                 520                 525            
 Thr Leu Leu Pro Gln Val Ser Thr Thr Phe Ala Asp Glu Arg Gly Arg
     530                 535                 540                
 Leu Lys Asp Glu Ile Ile His Lys Tyr Leu Tyr Glu Leu Glu His Ala
 545                 550                 555                 560
 Leu Ser Ser Ala Val Leu Gly Phe Gln Ser Asn Gln Ile Tyr Gly Phe
                 565                 570                 575    
 Cys Ser Gln Val Pro Tyr Ile Cys Ser Tyr Leu Leu Pro Glu Glu Glu
             580                 585                 590        
 His Thr Gly Ile Tyr Ile Leu Lys Pro Tyr Lys Lys Val Gln Ser Arg
         595                 600                 605            
 Gln Tyr Gly Pro Gly Leu Leu Tyr Leu Ser Ser His Gly Leu Trp Leu
     610                 615                 620                
 Ile Thr Ile Ala Lys Cys Gly Ile Leu Cys Ile Arg Asp Val Tyr Thr
 625                 630                 635                 640
 Leu Gly His Gly Ile Gln Ser Met Arg Ile Ser Met Asp Gly Gln Asn
                 645                 650                 655    
 Ile Leu Val Asn Gly Arg Asp Asp Gly Thr Leu Val Tyr Leu Lys Trp
             660                 665                 670        
 Lys Tyr Val Gln Tyr Ser Thr Cys Leu Ser Phe Ser Thr Met Tyr Gln
         675                 680                 685            
 Lys Gln Lys Ala Ser Thr Asp Leu Ser Gln Asp Glu Leu Val Leu Thr
     690                 695                 700                
 Asp Val Lys Lys Glu Ile Pro Trp Ile Gln Gln Lys Ser Gln Glu Val
 705                 710                 715                 720
 Phe Val Lys His Gly Val Gly Leu Lys
                 725                



      <210> 920
      <211> 307
      <212> PRT
      <213> Homo sapiens


      <400> 920
 Met Ala Ala Leu Tyr Ala Cys Thr Lys Cys His Gln Arg Phe Pro Phe
   1               5                  10                  15    
 Glu Ala Leu Ser Gln Gly Gln Gln Leu Cys Lys Glu Cys Arg Ile Ala
              20                  25                  30        
 His Pro Val Val Lys Cys Thr Tyr Cys Arg Thr Glu Tyr Gln Gln Glu
          35                  40                  45            
 Ser Lys Thr Asn Thr Ile Cys Lys Lys Cys Ala Gln Asn Val Gln Leu
      50                  55                  60                
 Tyr Gly Thr Pro Lys Pro Cys Gln Tyr Cys Asn Ile Ile Ala Ala Phe
  65                  70                  75                  80
 Ile Gly Asn Lys Cys Gln Arg Cys Thr Asn Ser Glu Lys Lys Tyr Gly
                  85                  90                  95    
 Pro Pro Tyr Ser Cys Glu Gln Cys Lys Gln Gln Cys Ala Phe Asp Arg
             100                 105                 110        
 Lys Asp Asp Arg Lys Lys Val Asp Gly Lys Leu Leu Cys Trp Leu Cys
         115                 120                 125            
 Thr Leu Ser Tyr Lys Arg Val Leu Gln Lys Thr Lys Glu Gln Arg Lys
     130                 135                 140                
 His Leu Ser Ser Ser Ser Arg Ala Gly His Gln Glu Lys Glu Gln Tyr
 145                 150                 155                 160
 Ser Arg Leu Ser Gly Gly Gly His Tyr Asn Ser Gln Lys Thr Leu Ser
                 165                 170                 175    
 Thr Ser Ser Ile Gln Asn Glu Ile Pro Lys Lys Lys Ser Lys Phe Glu
             180                 185                 190        
 Ser Ile Thr Thr Asn Gly Asp Ser Phe Ser Pro Asp Leu Ala Leu Asp
         195                 200                 205            
 Ser Pro Gly Thr Asp His Phe Val Ile Ile Ala Gln Leu Lys Glu Glu
     210                 215                 220                
 Val Ala Thr Leu Lys Lys Met Leu His Gln Lys Asp Gln Met Ile Leu
 225                 230                 235                 240
 Glu Lys Glu Lys Lys Ile Thr Glu Leu Lys Ala Asp Phe Gln Tyr Gln
                 245                 250                 255    
 Glu Ser Gln Met Arg Ala Lys Met Asn Gln Met Glu Lys Thr His Lys
             260                 265                 270        
 Glu Val Thr Glu Gln Leu Gln Ala Lys Asn Arg Glu Leu Leu Lys Gln
         275                 280                 285            
 Ala Ala Ala Leu Ser Lys Ser Lys Lys Ser Glu Lys Ser Gly Ala Ile
     290                 295                 300                
 Thr Ser Pro
 305        



      <210> 921
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 921
 Met Pro Leu Trp Ala Ser Gln Asn Pro Leu Ser Leu Ser Thr Gly Ala
   1               5                  10                  15    
 Met Cys Glu Ile Pro Ala Gln Ala Val Pro Gly His Thr Arg Lys Arg
              20                  25                  30        
 Val Leu Pro Gly Gly Gly Arg Ser Trp Ala Glu Gly Leu Arg Ser Glu
          35                  40                  45            
 Pro Leu Leu Leu Ala Val Trp His Arg Val Arg Glu Arg Ser Tyr Ala
      50                  55                  60                
 Ala Gln Ser Leu Phe Leu Leu Leu Leu Thr Ser Pro Thr Ser Pro Leu
  65                  70                  75                  80
 Pro Ile Val His Ser Gln Asn Tyr Cys Val Leu Asp Lys Leu Arg Asp
                  85                  90                  95    
 Phe Val Ala Ser Pro Pro Cys Trp Lys Val Ala Gln Val Asp Ser Leu
             100                 105                 110        
 Lys Asp Lys Ala Arg Lys Leu Tyr Thr Ile Met Asn Ser Phe Cys Arg
         115                 120                 125            
 Arg Val Ser Gly Cys His
     130                



      <210> 922
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 922
 Met Pro Leu Trp Ala Ser Gln Asn Pro Leu Ser Leu Ser Thr Gly Ala
   1               5                  10                  15    
 Met Cys Glu Ile Pro Ala Gln Ala Val Pro Gly His Thr Arg Lys Arg
              20                  25                  30        
 Val Leu Pro Gly Gly Gly Arg Ser Trp Ala Glu Gly Leu Arg Ser Glu
          35                  40                  45            
 Pro Leu Leu Leu Ala Val Trp His Arg Val Arg Glu Arg Ser Tyr Ala
      50                  55                  60                
 Ala Gln Ser Leu Phe Leu Leu Leu Leu Thr Ser Pro Thr Ser Pro Leu
  65                  70                  75                  80
 Pro Ile Val His Ser Gln Asn Tyr Cys Val Leu Asp Lys Leu Arg Asp
                  85                  90                  95    
 Phe Val Ala Ser Pro Pro Cys Trp Lys Val Ala Gln Val Asp Ser Leu
             100                 105                 110        
 Lys Asp Lys Ala Arg Lys Leu Tyr Thr Ile Met Asn Ser Phe Cys Arg
         115                 120                 125            
 Arg Val Ser Gly Cys His
     130                



      <210> 923
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 923
 Met Pro Leu Trp Ala Ser Gln Asn Pro Leu Ser Leu Ser Thr Gly Ala
   1               5                  10                  15    
 Met Cys Glu Ile Pro Ala Gln Ala Val Pro Gly His Thr Arg Lys Arg
              20                  25                  30        
 Val Leu Pro Gly Gly Gly Arg Ser Trp Ala Glu Gly Leu Arg Ser Glu
          35                  40                  45            
 Pro Leu Leu Leu Ala Val Trp His Arg Val Arg Glu Arg Ser Tyr Ala
      50                  55                  60                
 Ala Gln Ser Leu Phe Leu Leu Leu Leu Thr Ser Pro Thr Ser Pro Leu
  65                  70                  75                  80
 Pro Ile Val His Ser Gln Asn Tyr Cys Val Leu Asp Lys Leu Arg Asp
                  85                  90                  95    
 Phe Val Ala Ser Pro Pro Cys Trp Lys Val Ala Gln Val Asp Ser Leu
             100                 105                 110        
 Lys Asp Lys Ala Arg Lys Leu Tyr Thr Ile Met Asn Ser Phe Cys Arg
         115                 120                 125            
 Arg Asp Leu Val Phe Leu Leu Asp Asp Cys Asn Ala Leu Glu Tyr Pro
     130                 135                 140                
 Ile Pro Val Thr Thr Val Leu Pro Asp Arg Gln Arg
 145                 150                 155    



      <210> 924
      <211> 78
      <212> PRT
      <213> Homo sapiens


      <400> 924
 Met Arg Thr Pro Gly Pro Leu Pro Val Leu Leu Leu Leu Leu Ala Gly
   1               5                  10                  15    
 Ala Pro Ala Ala Arg Pro Thr Pro Pro Thr Cys Tyr Ser Arg Met Arg
              20                  25                  30        
 Ala Leu Ser Gln Glu Ile Thr Arg Asp Phe Asn Leu Leu Gln Val Ser
          35                  40                  45            
 Glu Pro Ser Asp Leu Val Phe Leu Leu Asp Asp Cys Asn Ala Leu Glu
      50                  55                  60                
 Tyr Pro Ile Pro Val Thr Thr Val Leu Pro Asp Arg Gln Arg
  65                  70                  75            



      <210> 925
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 925
 Met Arg Thr Pro Gly Pro Leu Pro Val Leu Leu Leu Leu Leu Ala Gly
   1               5                  10                  15    
 Ala Pro Ala Ala Arg Pro Thr Pro Pro Thr Cys Tyr Ser Arg Met Arg
              20                  25                  30        
 Ala Leu Ser Gln Glu Ile Thr Arg Asp Phe Asn Leu Leu Gln Val Ser
          35                  40                  45            
 Glu Pro Ser Glu Pro Cys Val Arg Tyr Leu Pro Arg Leu Tyr Leu Asp
      50                  55                  60                
 Ile His Asn Tyr Cys Val Leu Asp Lys Leu Arg Asp Phe Val Ala Ser
  65                  70                  75                  80
 Pro Pro Cys Trp Lys Val Ala Gln Val Asp Ser Leu Lys Asp Lys Ala
                  85                  90                  95    
 Arg Lys Leu Tyr Thr Ile Met Asn Ser Phe Cys Arg Arg Asp Leu Asp
             100                 105                 110        
 Asp Tyr Gly Pro Ala Arg Ser Ser Ala Leu Arg Glu Leu Arg Pro Glu
         115                 120                 125            
 Lys Glu Pro Lys Arg Thr Lys Val Met Ser Ala Thr Gln Thr
     130                 135                 140        



      <210> 926
      <211> 525
      <212> PRT
      <213> Homo sapiens


      <400> 926
 Met Ala Thr Leu Leu Arg Ser Lys Leu Ser Asn Val Ala Thr Ser Val
   1               5                  10                  15    
 Ser Asn Lys Ser Gln Ala Lys Met Ser Gly Met Phe Ala Arg Met Gly
              20                  25                  30        
 Phe Gln Ala Ala Thr Asp Glu Glu Ala Val Gly Phe Ala His Cys Asp
          35                  40                  45            
 Asp Leu Asp Phe Glu His Arg Gln Gly Leu Gln Met Asp Ile Leu Lys
      50                  55                  60                
 Ala Glu Gly Glu Pro Cys Gly Asp Glu Gly Ala Glu Ala His Val Glu
  65                  70                  75                  80
 Gly Asp Ile His Tyr Gln Arg Gly Ser Gly Ala Pro Leu Pro Pro Ser
                  85                  90                  95    
 Gly Ser Lys Asp Gln Val Gly Gly Gly Gly Glu Phe Gly Gly His Asp
             100                 105                 110        
 Lys Pro Lys Ile Thr Ala Trp Glu Ala Gly Trp Asn Val Thr Asn Ala
         115                 120                 125            
 Ile Gln Gly Met Phe Val Leu Gly Leu Pro Tyr Ala Ile Leu His Gly
     130                 135                 140                
 Gly Tyr Leu Gly Leu Phe Leu Ile Ile Phe Ala Ala Val Val Cys Cys
 145                 150                 155                 160
 Tyr Thr Gly Lys Ile Leu Ile Ala Cys Leu Tyr Glu Glu Asn Glu Asp
                 165                 170                 175    
 Gly Glu Val Val Arg Val Arg Asp Ser Tyr Val Ala Ile Ala Asn Ala
             180                 185                 190        
 Cys Cys Ala Pro Arg Phe Pro Thr Leu Gly Gly Arg Val Val Asn Val
         195                 200                 205            
 Ala Gln Ile Ile Glu Leu Val Met Thr Cys Ile Leu Tyr Val Val Val
     210                 215                 220                
 Ser Gly Asn Leu Met Tyr Asn Ser Phe Pro Gly Leu Pro Val Ser Gln
 225                 230                 235                 240
 Lys Ser Trp Ser Ile Ile Ala Thr Ala Val Leu Leu Pro Cys Ala Phe
                 245                 250                 255    
 Leu Lys Asn Leu Lys Ala Val Ser Lys Phe Ser Leu Leu Cys Thr Leu
             260                 265                 270        
 Ala His Phe Val Ile Asn Ile Leu Val Ile Ala Tyr Cys Leu Ser Arg
         275                 280                 285            
 Ala Arg Asp Trp Ala Trp Glu Lys Val Lys Phe Tyr Ile Asp Val Lys
     290                 295                 300                
 Lys Phe Pro Ile Ser Ile Gly Ile Ile Val Phe Ser Tyr Thr Ser Gln
 305                 310                 315                 320
 Ile Phe Leu Pro Ser Leu Glu Gly Asn Met Gln Gln Pro Ser Glu Phe
                 325                 330                 335    
 His Cys Met Met Asn Trp Thr His Ile Ala Ala Cys Val Leu Lys Gly
             340                 345                 350        
 Leu Phe Ala Leu Val Ala Tyr Leu Thr Trp Ala Asp Glu Thr Lys Glu
         355                 360                 365            
 Val Ile Thr Asp Asn Leu Pro Gly Ser Ile Arg Ala Val Val Asn Ile
     370                 375                 380                
 Phe Leu Val Ala Lys Ala Leu Leu Ser Tyr Pro Leu Pro Phe Phe Ala
 385                 390                 395                 400
 Ala Val Glu Val Leu Glu Lys Ser Leu Phe Gln Glu Gly Ser Arg Ala
                 405                 410                 415    
 Phe Phe Pro Ala Cys Tyr Ser Gly Asp Gly Arg Leu Lys Ser Trp Gly
             420                 425                 430        
 Leu Thr Leu Arg Cys Ala Leu Val Val Phe Thr Leu Leu Met Ala Ile
         435                 440                 445            
 Tyr Val Pro His Phe Ala Leu Leu Met Gly Leu Thr Gly Ser Leu Thr
     450                 455                 460                
 Gly Ala Gly Leu Cys Phe Leu Leu Pro Ser Leu Phe His Leu Arg Leu
 465                 470                 475                 480
 Leu Trp Arg Lys Leu Leu Trp His Gln Val Phe Phe Asp Val Ala Ile
                 485                 490                 495    
 Phe Val Ile Gly Gly Ile Cys Ser Val Ser Gly Phe Val His Ser Leu
             500                 505                 510        
 Glu Gly Leu Ile Glu Ala Tyr Arg Thr Asn Ala Glu Asp
         515                 520                 525



      <210> 927
      <211> 383
      <212> PRT
      <213> Homo sapiens


      <400> 927
 Met Pro Ser Gly Cys Arg Cys Leu His Leu Val Cys Leu Leu Cys Ile
   1               5                  10                  15    
 Leu Gly Ala Pro Gly Gln Pro Val Arg Ala Asp Asp Cys Ser Ser His
              20                  25                  30        
 Cys Asp Leu Ala His Gly Cys Cys Ala Pro Asp Gly Ser Cys Arg Cys
          35                  40                  45            
 Asp Pro Gly Trp Glu Gly Leu His Cys Glu Arg Cys Val Arg Met Pro
      50                  55                  60                
 Gly Cys Gln His Gly Thr Cys His Gln Pro Trp Gln Cys Ile Cys His
  65                  70                  75                  80
 Ser Gly Trp Ala Gly Lys Phe Cys Asp Lys Asp Glu His Ile Cys Thr
                  85                  90                  95    
 Thr Gln Ser Pro Cys Gln Asn Gly Gly Gln Cys Met Tyr Asp Gly Gly
             100                 105                 110        
 Gly Glu Tyr His Cys Val Cys Leu Pro Gly Phe His Gly Arg Asp Cys
         115                 120                 125            
 Glu Arg Lys Ala Gly Pro Cys Glu Gln Ala Gly Ser Pro Cys Arg Asn
     130                 135                 140                
 Gly Gly Gln Cys Gln Asp Asp Gln Gly Phe Ala Leu Asn Phe Thr Cys
 145                 150                 155                 160
 Arg Cys Leu Val Gly Phe Val Gly Ala Arg Cys Glu Val Asn Val Asp
                 165                 170                 175    
 Asp Cys Leu Met Arg Pro Cys Ala Asn Gly Ala Thr Cys Leu Asp Gly
             180                 185                 190        
 Ile Asn Arg Phe Ser Cys Leu Cys Pro Glu Gly Phe Ala Gly Arg Phe
         195                 200                 205            
 Cys Thr Ile Asn Leu Asp Asp Cys Ala Ser Arg Pro Cys Gln Arg Gly
     210                 215                 220                
 Ala Arg Cys Arg Asp Arg Val His Asp Phe Asp Cys Leu Cys Pro Ser
 225                 230                 235                 240
 Gly Tyr Gly Gly Lys Thr Cys Glu Leu Val Leu Pro Val Pro Asp Pro
                 245                 250                 255    
 Pro Thr Thr Val Asp Thr Pro Leu Gly Pro Thr Ser Ala Val Val Val
             260                 265                 270        
 Pro Ala Thr Gly Pro Ala Pro His Ser Ala Gly Ala Gly Leu Leu Arg
         275                 280                 285            
 Ile Ser Val Lys Glu Val Val Arg Arg Gln Glu Ala Gly Leu Gly Glu
     290                 295                 300                
 Pro Ser Leu Val Ala Leu Val Val Phe Gly Ala Leu Thr Ala Ala Leu
 305                 310                 315                 320
 Val Leu Ala Thr Val Leu Leu Thr Leu Arg Ala Trp Arg Arg Gly Val
                 325                 330                 335    
 Cys Pro Pro Gly Pro Cys Cys Tyr Pro Ala Pro His Tyr Ala Pro Ala
             340                 345                 350        
 Cys Gln Asp Gln Glu Cys Gln Val Ser Met Leu Pro Ala Gly Leu Pro
         355                 360                 365            
 Leu Pro Arg Asp Leu Pro Pro Glu Pro Gly Lys Thr Thr Ala Leu
     370                 375                 380            



      <210> 928
      <211> 544
      <212> PRT
      <213> Homo sapiens


      <400> 928
 Met Ser Lys Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Ala Ala Glu
   1               5                  10                  15    
 Ser Cys Ser Pro Ala Pro Ala Gly Ser Ser Ala Ala Pro Pro Ala Pro
              20                  25                  30        
 Val Glu Asp Leu Ser Lys Val Ser Asp Glu Glu Leu Leu Gln Trp Ser
          35                  40                  45            
 Lys Glu Glu Leu Ile Arg Ser Leu Arg Arg Ala Glu Ala Glu Lys Val
      50                  55                  60                
 Ser Ala Met Leu Asp His Ser Asn Leu Ile Arg Glu Val Asn Arg Arg
  65                  70                  75                  80
 Leu Gln Leu His Leu Gly Glu Ile Arg Gly Leu Lys Val Asp Trp Gly
                  85                  90                  95    
 Lys Glu Glu Glu Gln Arg Asp Ser Val Trp Lys Glu Gln His Phe Asp
             100                 105                 110        
 Arg Val Pro Gln Val Leu Glu Ala Arg His Lys Arg Asn His Cys Arg
         115                 120                 125            
 Asp Phe Arg Glu Gln Ile Pro Glu Gly Thr Ser Cys Ser Phe Pro Leu
     130                 135                 140                
 Ser Thr Pro Ile Pro Thr Tyr Gln Thr Val Asp Ala Val Pro Glu Leu
 145                 150                 155                 160
 Pro Gln Cys Ser Ser Ser Gly Ile Leu Gly Gln Glu Arg Val Gly Arg
                 165                 170                 175    
 Val Glu Cys Ser Arg Leu Thr Tyr Val Leu Gly Pro Val Gln Asp Ile
             180                 185                 190        
 Asn Gln Lys Leu Gln Glu Asp Asn Gln Glu Leu Arg Asp Leu Cys Cys
         195                 200                 205            
 Phe Leu Asp Asp Asp Arg Gln Lys Gly Lys Arg Val Ser Arg Glu Trp
     210                 215                 220                
 Gln Arg Leu Gly Arg Tyr Thr Ala Gly Val Met His Lys Glu Val Ala
 225                 230                 235                 240
 Leu Tyr Leu Gln Lys Leu Lys Asp Leu Glu Val Lys Gln Glu Glu Val
                 245                 250                 255    
 Val Lys Glu Asn Met Glu Leu Lys Glu Leu Cys Val Leu Leu Asp Glu
             260                 265                 270        
 Glu Lys Gly Ala Gly Cys Ala Gly Ser Arg Cys Ser Ile Asp Ser Gln
         275                 280                 285            
 Ala Ser Leu Cys Gln Leu Thr Ala Ser Thr Ala Pro Tyr Val Arg Asp
     290                 295                 300                
 Val Gly Asp Gly Ser Ser Thr Ser Ser Thr Gly Ser Thr Asp Ser Pro
 305                 310                 315                 320
 Asp His His Lys His His Ala Ser Ser Gly Ser Pro Glu His Leu Gln
                 325                 330                 335    
 Lys Pro Arg Ser Glu Gly Ser Pro Glu His Ser Lys His Arg Ser Ala
             340                 345                 350        
 Ser Pro Glu His Pro Gln Lys Pro Arg Ala Cys Gly Thr Pro Asp Arg
         355                 360                 365            
 Pro Lys Ala Leu Lys Gly Pro Ser Pro Glu His His Lys Pro Leu Cys
     370                 375                 380                
 Lys Gly Ser Pro Glu Gln Gln Arg His Pro His Pro Gly Ser Ser Pro
 385                 390                 395                 400
 Glu Thr Leu Pro Lys His Val Leu Ser Gly Ser Pro Glu His Phe Gln
                 405                 410                 415    
 Lys His Arg Ser Gly Ser Ser Pro Glu His Ala Arg His Ser Gly Gly
             420                 425                 430        
 Ser Pro Glu His Leu Gln Lys His Ala Leu Gly Gly Ser Leu Glu His
         435                 440                 445            
 Leu Pro Arg Ala Arg Gly Thr Ser Pro Glu His Leu Lys Gln His Tyr
     450                 455                 460                
 Gly Gly Ser Pro Asp His Lys His Gly Gly Gly Ser Gly Gly Ser Gly
 465                 470                 475                 480
 Gly Ser Gly Gly Gly Ser Arg Glu Gly Thr Leu Arg Arg Gln Ala Gln
                 485                 490                 495    
 Glu Asp Gly Ser Pro His His Arg Asn Val Tyr Ser Gly Met Asn Asp
             500                 505                 510        
 Ser Lys Cys Gln Phe Thr His Pro Pro Lys Gln Asn Asn Lys Thr Leu
         515                 520                 525            
 Lys Gly Lys Ser Leu Val Ile Ser Ala Asp Asp Gly Leu Asp Val Ile
     530                 535                 540                





      <210> 929
      <211> 172
      <212> PRT
      <213> Homo sapiens


      <400> 929
 Met Ser Arg Pro Leu Leu Ile Thr Phe Thr Pro Ala Thr Asp Pro Ser
   1               5                  10                  15    
 Asp Leu Trp Lys Asp Gly Gln Gln Gln Pro Gln Pro Glu Lys Pro Glu
              20                  25                  30        
 Ser Thr Leu Asp Gly Ala Ala Ala Arg Ala Phe Tyr Glu Ala Leu Ile
          35                  40                  45            
 Gly Asp Glu Ser Ser Ala Pro Asp Ser Gln Arg Ser Gln Thr Glu Pro
      50                  55                  60                
 Ala Arg Glu Arg Lys Arg Lys Lys Arg Arg Ile Met Lys Ala Pro Ala
  65                  70                  75                  80
 Ala Glu Ala Val Ala Glu Gly Ala Ser Gly Arg His Gly Gln Gly Arg
                  85                  90                  95    
 Ser Leu Glu Ala Glu Asp Lys Met Thr His Arg Ile Leu Arg Ala Ala
             100                 105                 110        
 Gln Glu Gly Asp Leu Pro Glu Leu Arg Arg Leu Leu Glu Pro His Glu
         115                 120                 125            
 Ala Gly Gly Ala Gly Gly Asn Ile Asn Ala Arg Asp Ala Phe Trp Trp
     130                 135                 140                
 Thr Pro Leu Met Cys Ala Ala Arg Ala Gly Gln Gly Ala Ala Val Ser
 145                 150                 155                 160
 Tyr Leu Leu Gly Val Gly Ala Ala Gly Trp Gly Leu
                 165                 170        



      <210> 930
      <211> 300
      <212> PRT
      <213> Homo sapiens


      <400> 930
 Met Ala Ala Leu Val Trp Leu Leu Ala Gly Ala Ser Met Ser Ser Leu
   1               5                  10                  15    
 Asn Lys Trp Ile Phe Thr Val His Gly Phe Gly Arg Pro Leu Leu Leu
              20                  25                  30        
 Ser Ala Leu His Met Leu Val Ala Ala Leu Ala Cys His Arg Gly Ala
          35                  40                  45            
 Arg Arg Pro Met Pro Gly Gly Thr Arg Cys Arg Val Leu Leu Leu Ser
      50                  55                  60                
 Leu Thr Phe Gly Thr Ser Met Ala Cys Gly Asn Val Gly Leu Arg Ala
  65                  70                  75                  80
 Val Pro Leu Asp Leu Ala Gln Leu Val Thr Thr Thr Thr Pro Leu Phe
                  85                  90                  95    
 Thr Leu Ala Leu Ser Ala Leu Leu Leu Gly Arg Arg His His Pro Leu
             100                 105                 110        
 Gln Leu Ala Ala Met Gly Pro Leu Cys Leu Gly Ala Ala Cys Ser Leu
         115                 120                 125            
 Ala Gly Glu Phe Arg Thr Pro Pro Thr Gly Cys Gly Phe Leu Leu Ala
     130                 135                 140                
 Ala Thr Cys Leu Arg Gly Leu Lys Ser Val Gln Gln Ser Ala Leu Leu
 145                 150                 155                 160
 Gln Glu Glu Arg Leu Asp Ala Val Thr Leu Leu Tyr Ala Thr Ser Leu
                 165                 170                 175    
 Pro Ser Phe Cys Leu Leu Ala Gly Ala Ala Leu Val Leu Glu Ala Gly
             180                 185                 190        
 Val Ala Pro Pro Pro Thr Ala Gly Asp Ser Arg Leu Trp Ala Cys Ile
         195                 200                 205            
 Leu Leu Ser Cys Leu Leu Ser Val Leu Tyr Asn Leu Ala Ser Phe Ser
     210                 215                 220                
 Leu Leu Ala Leu Thr Ser Ala Leu Thr Val His Val Leu Gly Asn Leu
 225                 230                 235                 240
 Thr Val Val Gly Asn Leu Ile Leu Ser Arg Leu Leu Phe Gly Ser Arg
                 245                 250                 255    
 Leu Ser Ala Leu Ser Tyr Val Gly Ile Ala Leu Thr Leu Ser Gly Met
             260                 265                 270        
 Phe Leu Tyr His Asn Cys Glu Phe Val Ala Ser Trp Ala Ala Arg Arg
         275                 280                 285            
 Gly Leu Trp Arg Arg Asp Gln Pro Ser Lys Gly Leu
     290                 295                 300



      <210> 931
      <211> 322
      <212> PRT
      <213> Homo sapiens


      <400> 931
 Met Leu Ala His Thr Gln Trp His Thr Cys Gln Arg Leu Ser Gln Leu
   1               5                  10                  15    
 Thr His Arg Ser Ile Leu Lys Tyr Leu Leu Ile Asp Thr His Ala Cys
              20                  25                  30        
 Gln Val Leu Ile Leu Lys His Thr His Ala Ser Leu Ser Leu Pro Ser
          35                  40                  45            
 Cys Gln Glu Cys Phe Pro Ser Ser Ile Pro Ser Ala Ser His Leu Val
      50                  55                  60                
 Ser His Pro His Pro Pro Pro Ser Pro Arg Trp Gly Gln Thr Pro Glu
  65                  70                  75                  80
 Gly Leu Pro Ala Ala Ser Pro Cys Gly Pro Gly Pro Arg Ser Cys Phe
                  85                  90                  95    
 Ser Ser Ile Leu Pro Thr Gly Asp Ser Trp Gly Met Leu Ala Cys Leu
             100                 105                 110        
 Cys Thr Val Leu Trp His Leu Pro Ala Val Pro Ala Leu Asn Arg Thr
         115                 120                 125            
 Gly Asp Pro Gly Pro Gly Pro Ser Ile Gln Lys Thr Tyr Asp Leu Thr
     130                 135                 140                
 Arg Tyr Leu Glu His Gln Leu Arg Ser Leu Ala Gly Thr Tyr Leu Asn
 145                 150                 155                 160
 Tyr Leu Gly Pro Pro Phe Asn Glu Pro Asp Phe Asn Pro Pro Arg Leu
                 165                 170                 175    
 Gly Ala Glu Thr Leu Pro Arg Ala Thr Val Asp Leu Glu Val Trp Arg
             180                 185                 190        
 Ser Leu Asn Asp Lys Leu Arg Leu Thr Gln Asn Tyr Glu Ala Tyr Ser
         195                 200                 205            
 His Leu Leu Cys Tyr Leu Arg Gly Leu Asn Arg Gln Ala Ala Thr Ala
     210                 215                 220                
 Glu Leu Arg Arg Ser Leu Ala His Phe Cys Thr Ser Leu Gln Gly Leu
 225                 230                 235                 240
 Leu Gly Ser Ile Ala Gly Val Met Ala Ala Leu Gly Tyr Pro Leu Pro
                 245                 250                 255    
 Gln Pro Leu Pro Gly Thr Glu Pro Thr Trp Thr Pro Gly Pro Ala His
             260                 265                 270        
 Ser Asp Phe Leu Gln Lys Met Asp Asp Phe Trp Leu Leu Lys Glu Leu
         275                 280                 285            
 Gln Thr Trp Leu Trp Arg Ser Ala Lys Asp Phe Asn Arg Leu Lys Lys
     290                 295                 300                
 Lys Met Gln Pro Pro Ala Ala Ala Val Thr Leu His Leu Gly Ala His
 305                 310                 315                 320
 Gly Phe
        



      <210> 932
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 932
 Met Ser Phe Thr Val Ser Met Ala Ile Gly Leu Val Leu Gly Gly Phe
   1               5                  10                  15    
 Ile Trp Ala Val Phe Ile Cys Leu Ser Arg Arg Arg Arg Ala Ser Ala
              20                  25                  30        
 Pro Ile Ser Gln Trp Ser Ser Ser Arg Arg Ser Arg Ser Ser Tyr Thr
          35                  40                  45            
 His Gly Leu Asn Arg Thr Gly Phe Tyr Arg His Ser Gly Cys Glu Arg
      50                  55                  60                
 Arg Ser Asn Leu Ser Leu Ala Ser Leu Thr Phe Gln Arg Gln Ala Ser
  65                  70                  75                  80
 Leu Glu Gln Ala Asn Ser Phe Pro Arg Lys Ser Ser Phe Arg Ala Ser
                  85                  90                  95    
 Thr Phe His Pro Phe Leu Gln Cys Pro Pro Leu Pro Val Glu Ile Glu
             100                 105                 110        
 Ser Gln Leu Val Thr Leu Pro Ser Ser Asn Ile Ser Pro Thr Ile Ser
         115                 120                 125            
 Thr Ser His Ser Leu Ser Arg Pro Asp Tyr Trp Ser Ser Asn Ser Leu
     130                 135                 140                
 Arg Val Gly Leu Ser Thr Pro Pro Pro Pro Ala Tyr Glu Ser Ile Ile
 145                 150                 155                 160
 Lys Ala Phe Pro Asp Ser
                 165    



      <210> 933
      <211> 335
      <212> PRT
      <213> Homo sapiens


      <400> 933
 Met Ala Ala Pro Ser Gly Val His Leu Leu Val Arg Arg Gly Ser His
   1               5                  10                  15    
 Arg Ile Phe Ser Ser Pro Leu Asn His Ile Tyr Leu His Lys Gln Ser
              20                  25                  30        
 Ser Ser Gln Gln Arg Arg Asn Phe Phe Phe Arg Arg Gln Arg Asp Ile
          35                  40                  45            
 Ser His Ser Ile Val Leu Pro Ala Ala Val Ser Ser Ala His Pro Val
      50                  55                  60                
 Pro Lys His Ile Lys Lys Pro Asp Tyr Val Thr Thr Gly Ile Val Pro
  65                  70                  75                  80
 Asp Trp Gly Asp Ser Ile Glu Val Lys Asn Glu Asp Gln Ile Gln Gly
                  85                  90                  95    
 Leu His Gln Ala Cys Gln Leu Ala Arg His Val Leu Leu Leu Ala Gly
             100                 105                 110        
 Lys Ser Leu Lys Val Asp Met Thr Thr Glu Glu Ile Asp Ala Leu Val
         115                 120                 125            
 His Arg Glu Ile Ile Ser His Asn Ala Tyr Pro Ser Pro Leu Gly Tyr
     130                 135                 140                
 Gly Gly Phe Pro Lys Ser Val Cys Thr Ser Val Asn Asn Val Leu Cys
 145                 150                 155                 160
 His Gly Ile Pro Asp Ser Arg Pro Leu Gln Asp Gly Asp Ile Ile Asn
                 165                 170                 175    
 Ile Asp Val Thr Val Tyr Tyr Asn Gly Tyr His Gly Asp Thr Ser Glu
             180                 185                 190        
 Thr Phe Leu Val Gly Asn Val Asp Glu Cys Gly Lys Lys Leu Val Glu
         195                 200                 205            
 Val Ala Arg Arg Cys Arg Asp Glu Ala Ile Ala Ala Cys Arg Ala Gly
     210                 215                 220                
 Ala Pro Phe Ser Val Ile Gly Asn Thr Ile Ser His Ile Thr His Gln
 225                 230                 235                 240
 Asn Gly Phe Gln Val Cys Pro His Phe Val Gly His Gly Ile Gly Ser
                 245                 250                 255    
 Tyr Phe His Gly His Pro Glu Ile Trp His His Ala Asn Asp Ser Asp
             260                 265                 270        
 Leu Pro Met Glu Glu Gly Met Ala Phe Thr Ile Glu Pro Ile Ile Thr
         275                 280                 285            
 Glu Gly Ser Pro Glu Phe Lys Val Leu Glu Asp Ala Trp Thr Val Val
     290                 295                 300                
 Ser Leu Asp Asn Gln Arg Ser Ala Gln Phe Glu His Thr Val Leu Ile
 305                 310                 315                 320
 Thr Ser Arg Gly Ala Gln Ile Leu Thr Lys Leu Pro His Glu Ala
                 325                 330                 335



      <210> 934
      <211> 308
      <212> PRT
      <213> Homo sapiens


      <400> 934
 Met Arg Leu Leu Pro Glu Trp Phe Leu Leu Leu Phe Gly Pro Trp Leu
   1               5                  10                  15    
 Leu Arg Lys Ala Val Ser Ala Gln Ile Pro Glu Ser Gly Arg Pro Gln
              20                  25                  30        
 Tyr Leu Gly Leu Arg Pro Ala Ala Ala Gly Ala Gly Ala Pro Gly Gln
          35                  40                  45            
 Gln Leu Pro Glu Pro Arg Ser Ser Asp Gly Leu Gly Val Gly Arg Ala
      50                  55                  60                
 Trp Ser Trp Ala Trp Pro Thr Asn His Thr Gly Ala Leu Ala Arg Ala
  65                  70                  75                  80
 Gly Ala Ala Gly Ala Leu Pro Ala Gln Arg Thr Lys Arg Lys Pro Ser
                  85                  90                  95    
 Ile Lys Ala Ala Arg Ala Lys Lys Ile Phe Gly Trp Gly Asp Phe Tyr
             100                 105                 110        
 Phe Arg Val His Thr Leu Lys Phe Ser Leu Leu Val Thr Gly Lys Ile
         115                 120                 125            
 Val Asp His Val Asn Gly Thr Phe Ser Val Tyr Phe Arg His Asn Ser
     130                 135                 140                
 Ser Ser Leu Gly Asn Leu Ser Val Ser Ile Val Pro Pro Ser Lys Arg
 145                 150                 155                 160
 Val Glu Phe Gly Gly Val Trp Leu Pro Gly Pro Val Pro His Pro Leu
                 165                 170                 175    
 Gln Ser Thr Leu Ala Leu Glu Gly Val Leu Pro Gly Leu Gly Pro Pro
             180                 185                 190        
 Leu Gly Met Ala Ala Ala Ala Ala Gly Pro Gly Leu Gly Gly Ser Leu
         195                 200                 205            
 Gly Gly Ala Leu Ala Gly Pro Leu Gly Gly Ala Leu Gly Val Pro Gly
     210                 215                 220                
 Ala Lys Glu Ser Arg Ala Phe Asn Cys His Val Glu Tyr Glu Lys Thr
 225                 230                 235                 240
 Asn Arg Ala Arg Lys His Arg Pro Cys Leu Tyr Asp Pro Ser Gln Val
                 245                 250                 255    
 Cys Phe Thr Glu His Thr Gln Ser Gln Ala Ala Trp Leu Cys Ala Lys
             260                 265                 270        
 Pro Phe Lys Val Ile Cys Ile Phe Val Ser Phe Leu Ser Phe Asp Tyr
         275                 280                 285            
 Lys Leu Val Gln Lys Val Cys Pro Asp Tyr Asn Phe Gln Ser Glu His
     290                 295                 300                
 Pro Tyr Phe Gly
 305            



      <210> 935
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 935
 Met Leu Ile Phe Phe Leu Gln Ser Met Glu Asn Thr Leu Asp Val Ile
   1               5                  10                  15    
 Glu His Leu Ala Asn Asn Val Lys Glu Lys Leu Ser Glu Lys Gln Ala
              20                  25                  30        
 Tyr Ser Phe Gln Leu Ser Lys Glu Thr Glu Glu Gln Lys Pro Lys Leu
          35                  40                  45            
 Glu Arg Val Thr Lys Gln Val Ser Ile Ser Phe Lys Asn
      50                  55                  60    



      <210> 936
      <211> 140
      <212> PRT
      <213> Homo sapiens


      <400> 936
 Met Gln Leu Met Pro Lys Leu Trp Cys Pro Val Cys Ser Ser Pro Gly
   1               5                  10                  15    
 Ser His Cys His Leu Gln Arg Gly Ser Leu Leu Arg Pro Thr Leu Leu
              20                  25                  30        
 His Leu Ala Pro Pro Trp Leu Leu Ala Trp Pro Asn Leu Ala Phe Cys
          35                  40                  45            
 Ala Met Leu Glu Leu Glu Leu Leu Leu Phe Phe Arg Gly Gly Asn Arg
      50                  55                  60                
 Val Glu Ser Gly Lys Gly Leu Ala Pro Lys Cys Cys Cys Cys Gly Phe
  65                  70                  75                  80
 Phe Ala Phe Ser Lys Asp Ala Leu Pro Gly Pro Lys Leu Gln Thr Ala
                  85                  90                  95    
 Val Leu Ser Lys Gln Val Arg Ser Leu Gly Phe Gly Ala His Leu Leu
             100                 105                 110        
 Ser Gly Ser Ile Ser Ile Leu Leu Leu Ala Thr Ser Gly Gln Arg Pro
         115                 120                 125            
 Pro Gln Pro His Ile Ala Arg Cys Trp Gln Lys Gly
     130                 135                 140



      <210> 937
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 937
 Met Thr Asp Pro Leu Cys His Leu Ser Ser Leu Thr Leu Ser His Cys
   1               5                  10                  15    
 Lys Leu Pro Asp Ala Val Cys Arg Asp Leu Ser Glu Ala Leu Arg Ala
              20                  25                  30        
 Ala Pro Ala Leu Thr Glu Leu Gly Leu Leu His Asn Arg Leu Ser Glu
          35                  40                  45            
 Ala Gly Leu Arg Met Leu Ser Glu Gly Leu Ala Trp Pro Gln Cys Arg
      50                  55                  60                
 Val Gln Thr Val Arg Val Gln Leu Pro Asp Pro Gln Arg Gly Leu Gln
  65                  70                  75                  80
 Tyr Leu Val Gly Met Leu Arg Gln Ser Pro Ala Leu Thr Thr Leu Asp
                  85                  90                  95    
 Leu Ser Gly Cys Gln Leu Pro Ala Pro Met Val Thr Tyr Leu Cys Ala
             100                 105                 110        
 Val Leu Gln His Gln Gly Cys Gly Leu Gln Thr Leu Ser Leu Ala Ser
         115                 120                 125            
 Val Glu Leu Ser Glu Gln Ser Leu Gln Glu Leu Gln Ala Val Lys Arg
     130                 135                 140                
 Ala Lys Pro Asp Leu Val Ile Ala His Pro Ala Leu Asp Gly His Pro
 145                 150                 155                 160
 Gln Pro Pro Lys Glu Leu Ile Ser Thr Phe
                 165                 170



      <210> 938
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 938
 Met Ala Ala Leu Val Glu Pro Leu Gly Leu Glu Arg Asp Val Ser Arg
   1               5                  10                  15    
 Ala Val Glu Leu Leu Glu Arg Leu Gln Arg Ser Gly Glu Leu Pro Pro
              20                  25                  30        
 Gln Lys Leu Gln Ala Leu Gln Arg Val Leu Gln Ser Arg Phe Cys Ser
          35                  40                  45            
 Ala Ile Arg Glu Val Tyr Glu Gln Leu Tyr Asp Thr Leu Asp Ile Thr
      50                  55                  60                
 Gly Ser Ala Glu Ile Arg Ala His Ala Thr Ala Lys Ala Thr Val Ala
  65                  70                  75                  80
 Ala Phe Thr Ala Ser Glu Gly His Ala His Pro Arg Val Val Glu Leu
                  85                  90                  95    
 Pro Lys Thr Asp Glu Gly Leu Gly Phe Asn Ile Met Gly Gly Lys Glu
             100                 105                 110        
 Gln Asn Ser Pro Ile Tyr Ile Ser Arg Val Ile Pro Gly Gly Val Ala
         115                 120                 125            
 Asp Arg His Gly Gly Leu Lys Arg Gly Asp Gln Leu Leu Ser Val Asn
     130                 135                 140                
 Gly Val Ser Val Glu Gly Glu Gln His Glu Lys Ala Val Glu Leu Leu
 145                 150                 155                 160
 Lys Ala Ala Gln Gly Ser Val Lys Leu Val Val Arg Tyr Thr Pro Arg
                 165                 170                 175    
 Val Leu Glu Glu Met Glu Ala Arg Phe Glu Lys Met Arg Ser Ala Arg
             180                 185                 190        
 Arg Arg Gln Gln His Gln Ser Tyr Ser Ser Leu Glu Ser Arg Gly
         195                 200                 205        



      <210> 939
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 939
 Met Ala Gln Leu Glu Gly Tyr Cys Phe Ser Ala Ala Leu Ser Cys Thr
   1               5                  10                  15    
 Phe Leu Val Ser Cys Leu Leu Phe Ser Ala Phe Ser Trp Ala Leu Arg
              20                  25                  30        
 Glu Pro Tyr Met Asp Glu Ile Phe His Leu Pro Gln Ala Gln Arg Tyr
          35                  40                  45            
 Cys Glu Gly His Phe Ser Leu Ser Gln Trp Asp Pro Met Ile Thr Thr
      50                  55                  60                
 Leu Pro Gly Leu Tyr Leu Val Ser Val Gly Val Val Lys Pro Ala Ile
  65                  70                  75                  80
 Trp Ile Phe Gly Trp Ser Glu His Val Val Cys Ser Ile Gly Met Leu
                  85                  90                  95    
 Arg Phe Val Asn Leu Leu Phe Ser Val Gly Asn Phe Tyr Leu Leu Tyr
             100                 105                 110        
 Leu Leu Phe His Lys Val Gln Pro Arg Asn Lys Ala Ala Ser Ser Ile
         115                 120                 125            
 Gln Arg Val Leu Ser Thr Leu Thr Leu Ala Val Phe Pro Thr Leu Tyr
     130                 135                 140                
 Phe Phe
 145    



      <210> 940
      <211> 531
      <212> PRT
      <213> Homo sapiens


      <400> 940
 Met Asp Gly Ile Val Pro Asp Ile Ala Val Gly Thr Lys Arg Gly Ser
   1               5                  10                  15    
 Asp Glu Leu Phe Ser Thr Cys Val Thr Asn Gly Pro Phe Ile Met Ser
              20                  25                  30        
 Ser Asn Ser Ala Ser Ala Ala Asn Gly Asn Asp Ser Lys Lys Phe Lys
          35                  40                  45            
 Gly Asp Ser Arg Ser Ala Gly Val Pro Ser Arg Val Ile His Ile Arg
      50                  55                  60                
 Lys Leu Pro Ile Asp Val Thr Glu Gly Glu Val Ile Ser Leu Gly Leu
  65                  70                  75                  80
 Pro Phe Gly Lys Val Thr Asn Leu Leu Met Leu Lys Gly Lys Asn Gln
                  85                  90                  95    
 Ala Phe Ile Glu Met Asn Thr Glu Glu Ala Ala Asn Thr Met Val Asn
             100                 105                 110        
 Tyr Tyr Thr Ser Val Thr Pro Val Leu Arg Gly Gln Pro Ile Tyr Ile
         115                 120                 125            
 Gln Phe Ser Asn His Lys Glu Leu Lys Thr Asp Ser Ser Pro Asn Gln
     130                 135                 140                
 Ala Arg Ala Gln Ala Ala Leu Gln Ala Val Asn Ser Val Gln Ser Gly
 145                 150                 155                 160
 Asn Leu Ala Leu Ala Ala Ser Ala Ala Ala Val Asp Ala Gly Met Ala
                 165                 170                 175    
 Met Ala Gly Gln Ser Pro Val Leu Arg Ile Ile Val Glu Asn Leu Phe
             180                 185                 190        
 Tyr Pro Val Thr Leu Asp Val Leu His Gln Ile Phe Ser Lys Phe Gly
         195                 200                 205            
 Thr Val Leu Lys Ile Ile Thr Phe Thr Lys Asn Asn Gln Phe Gln Ala
     210                 215                 220                
 Leu Leu Gln Tyr Ala Asp Pro Val Ser Ala Gln His Ala Lys Leu Ser
 225                 230                 235                 240
 Leu Asp Gly Gln Asn Ile Tyr Asn Ala Cys Cys Thr Leu Arg Ile Asp
                 245                 250                 255    
 Phe Ser Lys Leu Thr Ser Leu Asn Val Lys Tyr Asn Asn Asp Lys Ser
             260                 265                 270        
 Arg Asp Tyr Thr Arg Pro Asp Leu Pro Ser Gly Asp Ser Gln Pro Ser
         275                 280                 285            
 Leu Asp Gln Thr Met Ala Ala Ala Phe Gly Leu Ser Val Pro Asn Val
     290                 295                 300                
 His Gly Ala Leu Ala Pro Leu Ala Ile Pro Ser Ala Ala Ala Ala Ala
 305                 310                 315                 320
 Ala Ala Ala Gly Arg Ile Ala Ile Pro Gly Leu Ala Gly Ala Gly Asn
                 325                 330                 335    
 Ser Val Leu Leu Val Ser Asn Leu Asn Pro Glu Arg Val Thr Pro Gln
             340                 345                 350        
 Ser Leu Phe Ile Leu Phe Gly Val Tyr Gly Asp Val Gln Arg Val Lys
         355                 360                 365            
 Ile Leu Phe Asn Lys Lys Glu Asn Ala Leu Val Gln Met Ala Asp Gly
     370                 375                 380                
 Asn Gln Ala Gln Leu Ala Met Ser His Leu Asn Gly His Lys Leu His
 385                 390                 395                 400
 Gly Lys Pro Ile Arg Ile Thr Leu Ser Lys His Gln Asn Val Gln Leu
                 405                 410                 415    
 Pro Arg Glu Gly Gln Glu Asp Gln Gly Leu Thr Lys Asp Tyr Gly Asn
             420                 425                 430        
 Ser Pro Leu His Arg Phe Lys Lys Pro Gly Ser Lys Asn Phe Gln Asn
         435                 440                 445            
 Ile Phe Pro Pro Ser Ala Thr Leu His Leu Ser Asn Ile Pro Pro Ser
     450                 455                 460                
 Val Ser Glu Glu Asp Leu Lys Val Leu Phe Ser Ser Asn Gly Gly Val
 465                 470                 475                 480
 Val Lys Gly Phe Lys Phe Phe Gln Lys Asp Arg Lys Met Ala Leu Ile
                 485                 490                 495    
 Gln Met Gly Ser Val Glu Glu Ala Val Gln Ala Leu Ile Asp Leu His
             500                 505                 510        
 Asn His Asp Leu Gly Glu Asn His His Leu Arg Val Ser Phe Ser Lys
         515                 520                 525            
 Ser Thr Ile
     530    



      <210> 941
      <211> 554
      <212> PRT
      <213> Homo sapiens


      <400> 941
 Met Pro Leu Pro Trp Ser Leu Ala Leu Pro Leu Leu Leu Ser Trp Val
   1               5                  10                  15    
 Ala Gly Gly Phe Gly Asn Ala Ala Ser Ala Arg His His His Gly Leu
              20                  25                  30        
 Leu Ala Ser Ala Arg Gln Pro Gly Val Cys His Tyr Gly Thr Lys Leu
          35                  40                  45            
 Ala Cys Cys Tyr Gly Trp Arg Arg Asn Ser Lys Gly Val Cys Glu Ala
      50                  55                  60                
 Thr Cys Glu Pro Gly Cys Lys Phe Gly Glu Cys Val Gly Pro Asn Lys
  65                  70                  75                  80
 Cys Arg Cys Phe Pro Gly Tyr Thr Gly Lys Thr Cys Ser Gln Asp Val
                  85                  90                  95    
 Asn Glu Cys Gly Met Lys Pro Arg Pro Cys Gln His Arg Cys Val Asn
             100                 105                 110        
 Thr His Gly Ser Tyr Lys Cys Phe Cys Leu Ser Gly His Met Leu Met
         115                 120                 125            
 Pro Asp Ala Thr Cys Val Asn Ser Arg Thr Cys Ala Met Ile Asn Cys
     130                 135                 140                
 Gln Tyr Ser Cys Glu Asp Thr Glu Glu Gly Pro Gln Cys Leu Cys Pro
 145                 150                 155                 160
 Ser Ser Gly Leu Arg Leu Ala Pro Asn Gly Arg Asp Cys Leu Asp Ile
                 165                 170                 175    
 Asp Glu Cys Ala Ser Gly Lys Val Ile Cys Pro Tyr Asn Arg Arg Cys
             180                 185                 190        
 Val Asn Thr Phe Gly Ser Tyr Tyr Cys Lys Cys His Ile Gly Phe Glu
         195                 200                 205            
 Leu Gln Tyr Ile Ser Gly Arg Tyr Asp Cys Ile Asp Ile Asn Glu Cys
     210                 215                 220                
 Thr Met Asp Ser His Thr Cys Ser His His Ala Asn Cys Phe Asn Thr
 225                 230                 235                 240
 Gln Gly Ser Phe Lys Cys Lys Cys Lys Gln Gly Tyr Lys Gly Asn Gly
                 245                 250                 255    
 Leu Arg Cys Ser Ala Ile Pro Glu Asn Ser Val Lys Glu Val Leu Arg
             260                 265                 270        
 Ala Pro Gly Thr Ile Lys Asp Arg Ile Lys Lys Leu Leu Ala His Lys
         275                 280                 285            
 Asn Ser Met Lys Lys Lys Ala Lys Ile Lys Asn Val Thr Pro Glu Pro
     290                 295                 300                
 Thr Arg Thr Pro Thr Pro Lys Val Asn Leu Gln Pro Phe Asn Tyr Glu
 305                 310                 315                 320
 Glu Ile Val Ser Arg Gly Gly Asn Ser His Gly Gly Lys Lys Gly Asn
                 325                 330                 335    
 Glu Glu Lys Met Lys Glu Gly Leu Glu Asp Glu Lys Arg Glu Glu Lys
             340                 345                 350        
 Ala Leu Lys Asn Asp Ile Glu Glu Arg Ser Leu Arg Gly Asp Val Phe
         355                 360                 365            
 Phe Pro Lys Val Asn Glu Ala Gly Glu Phe Gly Leu Ile Leu Val Gln
     370                 375                 380                
 Arg Lys Ala Leu Thr Ser Lys Leu Glu His Lys Asp Leu Asn Ile Ser
 385                 390                 395                 400
 Val Asp Cys Ser Phe Asn His Gly Ile Cys Asp Trp Lys Gln Asp Arg
                 405                 410                 415    
 Glu Asp Asp Phe Asp Trp Asn Pro Ala Asp Arg Asp Asn Ala Ile Gly
             420                 425                 430        
 Phe Tyr Met Ala Val Pro Ala Leu Ala Gly His Lys Lys Asp Ile Gly
         435                 440                 445            
 Arg Leu Lys Leu Leu Leu Pro Asp Leu Gln Pro Gln Ser Asn Phe Cys
     450                 455                 460                
 Leu Leu Phe Asp Tyr Arg Leu Ala Gly Asp Lys Val Gly Lys Leu Arg
 465                 470                 475                 480
 Val Phe Val Lys Asn Ser Asn Asn Ala Leu Ala Trp Glu Lys Thr Thr
                 485                 490                 495    
 Ser Glu Asp Glu Lys Trp Lys Thr Gly Lys Ile Gln Leu Tyr Gln Gly
             500                 505                 510        
 Thr Asp Ala Thr Lys Ser Ile Ile Phe Glu Ala Glu Arg Gly Lys Gly
         515                 520                 525            
 Lys Thr Gly Glu Ile Ala Val Asp Gly Val Leu Leu Val Ser Gly Leu
     530                 535                 540                
 Cys Pro Asp Ser Leu Leu Ser Val Asp Asp
 545                 550                



      <210> 942
      <211> 559
      <212> PRT
      <213> Homo sapiens


      <400> 942
 Met Pro Leu Pro Trp Ser Leu Ala Leu Pro Leu Leu Leu Ser Trp Val
   1               5                  10                  15    
 Ala Gly Gly Phe Gly Asn Ala Ala Ser Ala Arg Gly Ser His His His
              20                  25                  30        
 His His His Gly Leu Leu Ala Ser Ala Arg Gln Pro Gly Val Cys His
          35                  40                  45            
 Tyr Gly Thr Lys Leu Ala Cys Cys Tyr Gly Trp Arg Arg Asn Ser Lys
      50                  55                  60                
 Gly Val Cys Glu Ala Thr Cys Glu Pro Gly Cys Lys Phe Gly Glu Cys
  65                  70                  75                  80
 Val Gly Pro Asn Lys Cys Arg Cys Phe Pro Gly Tyr Thr Gly Lys Thr
                  85                  90                  95    
 Cys Ser Gln Asp Val Asn Glu Cys Gly Met Lys Pro Arg Pro Cys Gln
             100                 105                 110        
 His Arg Cys Val Asn Thr His Gly Ser Tyr Lys Cys Phe Cys Leu Ser
         115                 120                 125            
 Gly His Met Leu Met Pro Asp Ala Thr Cys Val Asn Ser Arg Thr Cys
     130                 135                 140                
 Ala Met Ile Asn Cys Gln Tyr Ser Cys Glu Asp Thr Glu Glu Gly Pro
 145                 150                 155                 160
 Gln Cys Leu Cys Pro Ser Ser Gly Leu Arg Leu Ala Pro Asn Gly Arg
                 165                 170                 175    
 Asp Cys Leu Asp Ile Asp Glu Cys Ala Ser Gly Lys Val Ile Cys Pro
             180                 185                 190        
 Tyr Asn Arg Arg Cys Val Asn Thr Phe Gly Ser Tyr Tyr Cys Lys Cys
         195                 200                 205            
 His Ile Gly Phe Glu Leu Gln Tyr Ile Ser Gly Arg Tyr Asp Cys Ile
     210                 215                 220                
 Asp Ile Asn Glu Cys Thr Met Asp Ser His Thr Cys Ser His His Ala
 225                 230                 235                 240
 Asn Cys Phe Asn Thr Gln Gly Ser Phe Lys Cys Lys Cys Lys Gln Gly
                 245                 250                 255    
 Tyr Lys Gly Asn Gly Leu Arg Cys Ser Ala Ile Pro Glu Asn Ser Val
             260                 265                 270        
 Lys Glu Val Leu Arg Ala Pro Gly Thr Ile Lys Asp Arg Ile Lys Lys
         275                 280                 285            
 Leu Leu Ala His Lys Asn Ser Met Lys Lys Lys Ala Lys Ile Lys Asn
     290                 295                 300                
 Val Thr Pro Glu Pro Thr Arg Thr Pro Thr Pro Lys Val Asn Leu Gln
 305                 310                 315                 320
 Pro Phe Asn Tyr Glu Glu Ile Val Ser Arg Gly Gly Asn Ser His Gly
                 325                 330                 335    
 Gly Lys Lys Gly Asn Glu Glu Lys Met Lys Glu Gly Leu Glu Asp Glu
             340                 345                 350        
 Lys Arg Glu Glu Lys Ala Leu Lys Asn Asp Ile Glu Glu Arg Ser Leu
         355                 360                 365            
 Arg Gly Asp Val Phe Phe Pro Lys Val Asn Glu Ala Gly Glu Phe Gly
     370                 375                 380                
 Leu Ile Leu Val Gln Arg Lys Ala Leu Thr Ser Lys Leu Glu His Lys
 385                 390                 395                 400
 Asp Leu Asn Ile Ser Val Asp Cys Ser Phe Asn His Gly Ile Cys Asp
                 405                 410                 415    
 Trp Lys Gln Asp Arg Glu Asp Asp Phe Asp Trp Asn Pro Ala Asp Arg
             420                 425                 430        
 Asp Asn Ala Ile Gly Phe Tyr Met Ala Val Pro Ala Leu Ala Gly His
         435                 440                 445            
 Lys Lys Asp Ile Gly Arg Leu Lys Leu Leu Leu Pro Asp Leu Gln Pro
     450                 455                 460                
 Gln Ser Asn Phe Cys Leu Leu Phe Asp Tyr Arg Leu Ala Gly Asp Lys
 465                 470                 475                 480
 Val Gly Lys Leu Arg Val Phe Val Lys Asn Ser Asn Asn Ala Leu Ala
                 485                 490                 495    
 Trp Glu Lys Thr Thr Ser Glu Asp Glu Lys Trp Lys Thr Gly Lys Ile
             500                 505                 510        
 Gln Leu Tyr Gln Gly Thr Asp Ala Thr Lys Ser Ile Ile Phe Glu Ala
         515                 520                 525            
 Glu Arg Gly Lys Gly Lys Thr Gly Glu Ile Ala Val Asp Gly Val Leu
     530                 535                 540                
 Leu Val Ser Gly Leu Cys Pro Asp Ser Leu Leu Ser Val Asp Asp
 545                 550                 555                



      <210> 943
      <211> 1135
      <212> PRT
      <213> Homo sapiens


      <400> 943
 Met His Pro Gln Ser Leu Ala Glu Glu Glu Ile Lys Thr Glu Gln Glu
   1               5                  10                  15    
 Val Val Glu Gly Met Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser
              20                  25                  30        
 Ala Glu Arg Thr Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser
          35                  40                  45            
 Ser Asn Gly His Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys
      50                  55                  60                
 Lys Lys Lys Pro Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Asp Gly
  65                  70                  75                  80
 Arg Asn Asp Phe Tyr Cys Trp Val Cys His Arg Glu Gly Gln Val Leu
                  85                  90                  95    
 Cys Cys Glu Leu Cys Pro Arg Val Tyr His Ala Lys Cys Leu Arg Leu
             100                 105                 110        
 Thr Ser Glu Pro Glu Gly Asp Trp Phe Cys Pro Glu Cys Glu Lys Ile
         115                 120                 125            
 Thr Val Ala Glu Cys Ile Glu Thr Gln Ser Lys Ala Met Thr Met Leu
     130                 135                 140                
 Thr Ile Glu Gln Leu Ser Tyr Leu Leu Lys Phe Ala Ile Gln Lys Met
 145                 150                 155                 160
 Lys Gln Pro Gly Thr Asp Ala Phe Gln Lys Pro Val Pro Leu Glu Gln
                 165                 170                 175    
 His Pro Asp Tyr Ala Glu Tyr Ile Phe His Pro Met Asp Leu Cys Thr
             180                 185                 190        
 Leu Glu Lys Asn Ala Lys Lys Lys Met Tyr Gly Cys Thr Glu Ala Phe
         195                 200                 205            
 Leu Ala Asp Ala Lys Trp Ile Leu His Asn Cys Ile Ile Tyr Asn Gly
     210                 215                 220                
 Gly Asn His Lys Leu Thr Gln Ile Ala Lys Val Val Ile Lys Ile Cys
 225                 230                 235                 240
 Glu His Glu Met Asn Glu Ile Glu Val Cys Pro Glu Cys Tyr Leu Ala
                 245                 250                 255    
 Ala Cys Gln Lys Arg Asp Asn Trp Phe Cys Glu Pro Cys Ser Asn Pro
             260                 265                 270        
 His Pro Leu Val Trp Ala Lys Leu Lys Gly Phe Pro Phe Trp Pro Ala
         275                 280                 285            
 Lys Ala Leu Arg Asp Lys Asp Gly Gln Val Asp Ala Arg Phe Phe Gly
     290                 295                 300                
 Gln His Asp Arg Ala Trp Val Pro Ile Asn Asn Cys Tyr Leu Met Ser
 305                 310                 315                 320
 Lys Glu Ile Pro Phe Ser Val Lys Lys Thr Lys Ser Ile Phe Asn Ser
                 325                 330                 335    
 Ala Met Gln Glu Met Glu Val Tyr Val Glu Asn Ile Arg Arg Lys Phe
             340                 345                 350        
 Gly Val Phe Asn Tyr Ser Pro Phe Arg Thr Pro Tyr Thr Pro Asn Ser
         355                 360                 365            
 Gln Tyr Gln Met Leu Leu Asp Pro Thr Asn Pro Ser Ala Gly Thr Ala
     370                 375                 380                
 Lys Ile Asp Lys Gln Glu Lys Val Lys Leu Asn Phe Asp Met Thr Ala
 385                 390                 395                 400
 Ser Pro Lys Ile Leu Met Ser Lys Pro Val Leu Ser Gly Gly Thr Gly
                 405                 410                 415    
 Arg Arg Ile Ser Leu Ser Asp Met Pro Arg Ser Pro Met Ser Thr Asn
             420                 425                 430        
 Ser Ser Val His Thr Gly Ser Asp Val Glu Gln Asp Ala Glu Lys Lys
         435                 440                 445            
 Ala Thr Ser Ser His Phe Ser Ala Ser Glu Glu Ser Met Asp Phe Leu
     450                 455                 460                
 Asp Lys Ser Thr Ala Ser Pro Ala Ser Thr Lys Thr Gly Gln Ala Gly
 465                 470                 475                 480
 Ser Leu Ser Gly Ser Pro Lys Pro Phe Ser Pro Gln Leu Ser Ala Pro
                 485                 490                 495    
 Ile Thr Thr Lys Thr Asp Lys Thr Ser Thr Thr Gly Ser Ile Leu Asn
             500                 505                 510        
 Leu Asn Leu Asp Arg Ser Lys Ala Glu Met Asp Leu Lys Glu Leu Ser
         515                 520                 525            
 Glu Ser Val Gln Gln Gln Ser Thr Pro Val Pro Leu Ile Ser Pro Lys
     530                 535                 540                
 Arg Gln Ile Arg Ser Arg Phe Gln Leu Asn Leu Asp Lys Thr Ile Glu
 545                 550                 555                 560
 Ser Cys Lys Ala Gln Leu Gly Ile Asn Glu Ile Ser Glu Asp Val Tyr
                 565                 570                 575    
 Thr Ala Val Glu His Ser Asp Ser Glu Asp Ser Glu Lys Ser Asp Ser
             580                 585                 590        
 Ser Asp Ser Glu Tyr Ile Ser Asp Asp Glu Gln Lys Ser Lys Asn Glu
         595                 600                 605            
 Pro Glu Asp Thr Glu Asp Lys Glu Gly Cys Gln Met Asp Lys Glu Pro
     610                 615                 620                
 Ser Ala Val Lys Lys Lys Pro Lys Pro Thr Asn Pro Val Glu Ile Lys
 625                 630                 635                 640
 Glu Glu Leu Lys Ser Thr Ser Pro Ala Ser Glu Lys Ala Asp Pro Gly
                 645                 650                 655    
 Ala Val Lys Asp Lys Ala Ser Pro Glu Pro Glu Lys Asp Phe Ser Glu
             660                 665                 670        
 Lys Ala Lys Pro Ser Pro His Pro Ile Lys Asp Lys Leu Lys Gly Lys
         675                 680                 685            
 Asp Glu Thr Asp Ser Pro Thr Val His Leu Gly Leu Asp Ser Asp Ser
     690                 695                 700                
 Glu Ser Glu Leu Val Ile Asp Leu Gly Glu Asp His Ser Gly Arg Glu
 705                 710                 715                 720
 Gly Arg Lys Asn Lys Lys Glu Pro Lys Glu Pro Ser Pro Lys Gln Asp
                 725                 730                 735    
 Val Val Gly Lys Thr Pro Pro Ser Thr Thr Val Gly Ser His Ser Pro
             740                 745                 750        
 Pro Glu Thr Pro Val Leu Thr Arg Ser Ser Ala Gln Thr Ser Ala Ala
         755                 760                 765            
 Gly Ala Thr Ala Thr Thr Ser Thr Ser Ser Thr Val Thr Val Thr Ala
     770                 775                 780                
 Pro Ala Pro Ala Ala Thr Gly Ser Pro Val Lys Lys Gln Arg Pro Leu
 785                 790                 795                 800
 Leu Pro Lys Glu Thr Ala Pro Ala Val Gln Arg Val Val Trp Asn Ser
                 805                 810                 815    
 Ser Thr Val Gln Gln Lys Glu Ile Thr Gln Ser Pro Ser Thr Ser Thr
             820                 825                 830        
 Ile Thr Leu Val Thr Ser Thr Gln Ser Ser Pro Leu Val Thr Ser Ser
         835                 840                 845            
 Gly Ser Met Ser Thr Leu Val Ser Ser Val Asn Ala Asp Leu Pro Ile
     850                 855                 860                
 Ala Thr Ala Ser Ala Asp Val Ala Ala Asp Ile Ala Lys Tyr Thr Ser
 865                 870                 875                 880
 Lys Met Met Asp Ala Ile Lys Gly Thr Met Thr Glu Ile Tyr Asn Asp
                 885                 890                 895    
 Leu Ser Lys Asn Thr Thr Gly Ser Thr Ile Ala Glu Ile Arg Arg Leu
             900                 905                 910        
 Arg Ile Glu Ile Glu Lys Leu Gln Trp Leu His Gln Gln Glu Leu Ser
         915                 920                 925            
 Glu Met Lys His Asn Leu Glu Leu Thr Met Ala Glu Met Arg Gln Ser
     930                 935                 940                
 Leu Glu Gln Glu Arg Asp Arg Leu Ile Ala Glu Val Lys Lys Gln Leu
 945                 950                 955                 960
 Glu Leu Glu Lys Gln Gln Ala Val Asp Glu Thr Lys Lys Lys Gln Trp
                 965                 970                 975    
 Cys Ala Asn Cys Lys Lys Glu Ala Ile Phe Tyr Cys Cys Trp Asn Thr
             980                 985                 990        
 Ser Tyr Cys Asp Tyr Pro Cys Gln Gln Ala His Trp Pro Glu His Met
         995                1000                1005            
 Lys Ser Cys Thr Gln Ser Ala Thr Ala Pro Gln Gln Glu Ala Asp Ala
    1010                1015                1020                
 Glu Val Asn Thr Glu Thr Leu Asn Lys Ser Ser Gln Gly Ser Ser Ser
1025                1030                1035                1040
 Ser Thr Gln Ser Ala Pro Ser Glu Thr Ala Ser Ala Ser Lys Glu Lys
                1045                1050                1055    
 Glu Thr Ser Ala Glu Lys Ser Lys Glu Ser Gly Ser Thr Leu Asp Leu
            1060                1065                1070        
 Ser Gly Ser Arg Glu Thr Pro Ser Ser Ile Leu Leu Gly Ser Asn Gln
        1075                1080                1085            
 Gly Ser Asp His Ser Arg Ser Asn Lys Ser Ser Trp Ser Ser Ser Asp
    1090                1095                1100                
 Glu Lys Arg Gly Ser Thr Arg Ser Asp His Asn Thr Ser Thr Ser Thr
1105                1110                1115                1120
 Lys Ser Leu Leu Pro Lys Glu Ser Arg Leu Asp Thr Phe Trp Asp
                1125                1130                1135



      <210> 944
      <211> 739
      <212> PRT
      <213> Homo sapiens


      <400> 944
 Met His Pro Gln Ser Leu Ala Glu Glu Glu Ile Lys Thr Glu Gln Glu
   1               5                  10                  15    
 Val Val Glu Gly Met Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser
              20                  25                  30        
 Ala Glu Arg Thr Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser
          35                  40                  45            
 Ser Asn Gly His Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys
      50                  55                  60                
 Lys Lys Lys Pro Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Asp Gly
  65                  70                  75                  80
 Arg Asn Asp Phe Tyr Cys Trp Val Cys His Arg Glu Gly Gln Val Leu
                  85                  90                  95    
 Cys Cys Glu Leu Cys Pro Arg Val Tyr His Ala Lys Cys Leu Arg Leu
             100                 105                 110        
 Thr Ser Glu Pro Glu Gly Asp Trp Phe Cys Pro Glu Cys Glu Lys Ile
         115                 120                 125            
 Thr Val Ala Glu Cys Ile Glu Thr Gln Ser Lys Ala Met Thr Met Leu
     130                 135                 140                
 Thr Ile Glu Gln Leu Ser Tyr Leu Leu Lys Phe Ala Ile Gln Lys Met
 145                 150                 155                 160
 Lys Gln Pro Gly Thr Asp Ala Phe Gln Lys Pro Val Pro Leu Glu Gln
                 165                 170                 175    
 His Pro Asp Tyr Ala Glu Tyr Ile Phe His Pro Met Asp Leu Cys Thr
             180                 185                 190        
 Leu Glu Lys Asn Ala Lys Lys Lys Met Tyr Gly Cys Thr Glu Ala Phe
         195                 200                 205            
 Leu Ala Asp Ala Lys Trp Ile Leu His Asn Cys Ile Ile Tyr Asn Gly
     210                 215                 220                
 Gly Asn His Lys Leu Thr Gln Ile Ala Lys Val Val Ile Lys Ile Cys
 225                 230                 235                 240
 Glu His Glu Met Asn Glu Ile Glu Val Cys Pro Glu Cys Tyr Leu Ala
                 245                 250                 255    
 Ala Cys Gln Lys Arg Asp Asn Trp Phe Cys Glu Pro Cys Ser Asn Pro
             260                 265                 270        
 His Pro Leu Val Trp Ala Lys Leu Lys Gly Phe Pro Phe Trp Pro Ala
         275                 280                 285            
 Lys Ala Leu Arg Asp Lys Asp Gly Gln Val Asp Ala Arg Phe Phe Gly
     290                 295                 300                
 Gln His Asp Arg Ala Trp Val Pro Ile Asn Asn Cys Tyr Leu Met Ser
 305                 310                 315                 320
 Lys Glu Ile Pro Phe Ser Val Lys Lys Thr Lys Ser Ile Phe Asn Ser
                 325                 330                 335    
 Ala Met Gln Glu Met Glu Val Tyr Val Glu Asn Ile Arg Arg Lys Phe
             340                 345                 350        
 Gly Val Phe Asn Tyr Ser Pro Phe Arg Thr Pro Tyr Thr Pro Asn Ser
         355                 360                 365            
 Gln Tyr Gln Met Leu Leu Asp Pro Thr Asn Pro Ser Ala Gly Thr Ala
     370                 375                 380                
 Lys Ile Asp Lys Gln Glu Lys Val Lys Leu Asn Phe Asp Met Thr Ala
 385                 390                 395                 400
 Ser Pro Lys Ile Leu Met Ser Lys Pro Val Leu Ser Gly Gly Thr Gly
                 405                 410                 415    
 Arg Arg Ile Ser Leu Ser Asp Met Pro Arg Ser Pro Met Ser Thr Asn
             420                 425                 430        
 Ser Ser Val His Thr Gly Ser Asp Val Glu Gln Asp Ala Glu Lys Lys
         435                 440                 445            
 Ala Thr Ser Ser His Phe Ser Ala Ser Glu Glu Ser Met Asp Phe Leu
     450                 455                 460                
 Asp Lys Ser Thr Ala Ser Pro Ala Ser Thr Lys Thr Gly Gln Ala Gly
 465                 470                 475                 480
 Ser Leu Ser Gly Ser Pro Lys Pro Phe Ser Pro Gln Leu Ser Ala Pro
                 485                 490                 495    
 Ile Thr Thr Lys Thr Asp Lys Thr Ser Thr Thr Gly Ser Ile Leu Asn
             500                 505                 510        
 Leu Asn Leu Asp Arg Ser Lys Ala Glu Met Asp Leu Lys Glu Leu Ser
         515                 520                 525            
 Glu Ser Val Gln Gln Gln Ser Thr Pro Val Pro Leu Ile Ser Pro Lys
     530                 535                 540                
 Arg Gln Ile Arg Ser Arg Phe Gln Leu Asn Leu Asp Lys Thr Ile Glu
 545                 550                 555                 560
 Ser Cys Lys Ala Gln Leu Gly Ile Asn Glu Ile Ser Glu Asp Val Tyr
                 565                 570                 575    
 Thr Ala Val Glu His Ser Asp Ser Glu Asp Ser Glu Lys Ser Asp Ser
             580                 585                 590        
 Ser Asp Ser Glu Tyr Ile Ser Asp Asp Glu Gln Lys Ser Lys Asn Glu
         595                 600                 605            
 Pro Glu Asp Thr Glu Asp Lys Glu Gly Cys Gln Met Asp Lys Glu Pro
     610                 615                 620                
 Ser Ala Val Lys Lys Lys Pro Lys Pro Thr Asn Pro Val Glu Ile Lys
 625                 630                 635                 640
 Glu Glu Leu Lys Ser Thr Ser Pro Ala Ser Glu Lys Ala Asp Pro Gly
                 645                 650                 655    
 Ala Val Lys Asp Lys Ala Ser Pro Glu Pro Glu Lys Asp Phe Ser Glu
             660                 665                 670        
 Lys Ala Lys Pro Ser Pro His Pro Ile Lys Asp Lys Leu Lys Gly Lys
         675                 680                 685            
 Asp Glu Thr Asp Ser Pro Thr Val His Leu Gly Leu Asp Ser Asp Ser
     690                 695                 700                
 Glu Ser Glu Leu Val Ile Asp Leu Gly Glu Asp His Ser Gly Arg Glu
 705                 710                 715                 720
 Gly Arg Lys Asn Lys Lys Glu Pro Lys Glu Pro Ser Pro Lys Gln Asp
                 725                 730                 735    
 Gly Ile Gly
            



      <210> 945
      <211> 1181
      <212> PRT
      <213> Homo sapiens


      <400> 945
 Met His Pro Gln Ser Leu Ala Glu Glu Glu Ile Lys Thr Glu Gln Glu
   1               5                  10                  15    
 Val Val Glu Gly Met Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser
              20                  25                  30        
 Ala Glu Arg Thr Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser
          35                  40                  45            
 Ser Asn Gly His Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys
      50                  55                  60                
 Lys Lys Lys Pro Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Asp Gly
  65                  70                  75                  80
 Arg Asn Asp Phe Tyr Cys Trp Val Cys His Arg Glu Gly Gln Val Leu
                  85                  90                  95    
 Cys Cys Glu Leu Cys Pro Arg Val Tyr His Ala Lys Cys Leu Arg Leu
             100                 105                 110        
 Thr Ser Glu Pro Glu Gly Asp Trp Phe Cys Pro Glu Cys Glu Lys Ile
         115                 120                 125            
 Thr Val Ala Glu Cys Ile Glu Thr Gln Ser Lys Ala Met Thr Met Leu
     130                 135                 140                
 Thr Ile Glu Gln Leu Ser Tyr Leu Leu Lys Phe Ala Ile Gln Lys Met
 145                 150                 155                 160
 Lys Gln Pro Gly Thr Asp Ala Phe Gln Lys Pro Val Pro Leu Glu Gln
                 165                 170                 175    
 His Pro Asp Tyr Ala Glu Tyr Ile Phe His Pro Met Asp Leu Cys Thr
             180                 185                 190        
 Leu Glu Lys Asn Ala Lys Lys Lys Met Tyr Gly Cys Thr Glu Ala Phe
         195                 200                 205            
 Leu Ala Asp Ala Lys Trp Ile Leu His Asn Cys Ile Ile Tyr Asn Gly
     210                 215                 220                
 Gly Asn His Lys Leu Thr Gln Ile Ala Lys Val Val Ile Lys Ile Cys
 225                 230                 235                 240
 Glu His Glu Met Asn Glu Ile Glu Val Cys Pro Glu Cys Tyr Leu Ala
                 245                 250                 255    
 Ala Cys Gln Lys Arg Asp Asn Trp Phe Cys Glu Pro Cys Ser Asn Pro
             260                 265                 270        
 His Pro Leu Val Trp Ala Lys Leu Lys Gly Phe Pro Phe Trp Pro Ala
         275                 280                 285            
 Lys Ala Leu Arg Asp Lys Asp Gly Gln Val Asp Ala Arg Phe Phe Gly
     290                 295                 300                
 Gln His Asp Arg Ala Trp Val Pro Ile Asn Asn Cys Tyr Leu Met Ser
 305                 310                 315                 320
 Lys Glu Ile Pro Phe Ser Val Lys Lys Thr Lys Ser Ile Phe Asn Ser
                 325                 330                 335    
 Ala Met Gln Glu Met Glu Val Tyr Val Glu Asn Ile Arg Arg Lys Phe
             340                 345                 350        
 Gly Val Phe Asn Tyr Ser Pro Phe Arg Thr Pro Tyr Thr Pro Asn Ser
         355                 360                 365            
 Gln Tyr Gln Met Leu Leu Asp Pro Thr Asn Pro Ser Ala Gly Thr Ala
     370                 375                 380                
 Lys Ile Asp Lys Gln Glu Lys Val Lys Leu Asn Phe Asp Met Thr Ala
 385                 390                 395                 400
 Ser Pro Lys Ile Leu Met Ser Lys Pro Val Leu Ser Gly Gly Thr Gly
                 405                 410                 415    
 Arg Arg Ile Ser Leu Ser Asp Met Pro Arg Ser Pro Met Ser Thr Asn
             420                 425                 430        
 Ser Ser Val His Thr Gly Ser Asp Val Glu Gln Asp Ala Glu Lys Lys
         435                 440                 445            
 Ala Thr Ser Ser His Phe Ser Ala Ser Glu Glu Ser Met Asp Phe Leu
     450                 455                 460                
 Asp Lys Ser Thr Ala Ser Pro Ala Ser Thr Lys Thr Gly Gln Ala Gly
 465                 470                 475                 480
 Ser Leu Ser Gly Ser Pro Lys Pro Phe Ser Pro Gln Leu Ser Ala Pro
                 485                 490                 495    
 Ile Thr Thr Lys Thr Asp Lys Thr Ser Thr Thr Gly Ser Ile Leu Asn
             500                 505                 510        
 Leu Asn Leu Asp Arg Ser Lys Ala Glu Met Asp Leu Lys Glu Leu Ser
         515                 520                 525            
 Glu Ser Val Gln Gln Gln Ser Thr Pro Val Pro Leu Ile Ser Pro Lys
     530                 535                 540                
 Arg Gln Ile Arg Ser Arg Phe Gln Leu Asn Leu Asp Lys Thr Ile Glu
 545                 550                 555                 560
 Ser Cys Lys Ala Gln Leu Gly Ile Asn Glu Ile Ser Glu Asp Val Tyr
                 565                 570                 575    
 Thr Ala Val Glu His Ser Asp Ser Glu Asp Ser Glu Lys Ser Asp Ser
             580                 585                 590        
 Ser Asp Ser Glu Tyr Ile Ser Asp Asp Glu Gln Lys Ser Lys Asn Glu
         595                 600                 605            
 Pro Glu Asp Thr Glu Asp Lys Glu Gly Cys Gln Met Asp Lys Glu Pro
     610                 615                 620                
 Ser Ala Val Lys Lys Lys Pro Lys Pro Thr Asn Pro Val Glu Ile Lys
 625                 630                 635                 640
 Glu Glu Leu Lys Ser Thr Ser Pro Ala Ser Glu Lys Ala Asp Pro Gly
                 645                 650                 655    
 Ala Val Lys Asp Lys Ala Ser Pro Glu Pro Glu Lys Asp Phe Ser Glu
             660                 665                 670        
 Lys Ala Lys Pro Ser Pro His Pro Ile Lys Asp Lys Leu Lys Gly Lys
         675                 680                 685            
 Asp Glu Thr Asp Ser Pro Thr Val His Leu Gly Leu Asp Ser Asp Ser
     690                 695                 700                
 Glu Ser Glu Leu Val Ile Asp Leu Gly Glu Asp His Ser Gly Arg Glu
 705                 710                 715                 720
 Gly Arg Lys Asn Lys Lys Glu Pro Lys Glu Pro Ser Pro Lys Gln Asp
                 725                 730                 735    
 Val Val Gly Lys Thr Pro Pro Ser Thr Thr Val Gly Ser His Ser Pro
             740                 745                 750        
 Pro Glu Thr Pro Val Leu Thr Arg Ser Ser Ala Gln Thr Ser Ala Ala
         755                 760                 765            
 Gly Ala Thr Ala Thr Thr Ser Thr Ser Ser Thr Val Thr Val Thr Ala
     770                 775                 780                
 Pro Ala Pro Ala Ala Thr Gly Ser Pro Val Lys Lys Gln Arg Pro Leu
 785                 790                 795                 800
 Leu Pro Lys Glu Thr Ala Pro Ala Val Gln Arg Val Val Trp Asn Ser
                 805                 810                 815    
 Ser Ser Lys Phe Gln Thr Ser Ser Gln Lys Trp His Met Gln Lys Met
             820                 825                 830        
 Gln Arg Gln Gln Gln Gln Gln Gln Gln Gln Asn Gln Gln Gln Gln Pro
         835                 840                 845            
 Gln Ser Ser Gln Gly Thr Arg Tyr Gln Thr Arg Gln Ala Val Lys Ala
     850                 855                 860                
 Val Gln Gln Lys Glu Ile Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr
 865                 870                 875                 880
 Leu Val Thr Ser Thr Gln Ser Ser Pro Leu Val Thr Ser Ser Gly Ser
                 885                 890                 895    
 Met Ser Thr Leu Val Ser Ser Val Asn Ala Asp Leu Pro Ile Ala Thr
             900                 905                 910        
 Ala Ser Ala Asp Val Ala Ala Asp Ile Ala Lys Tyr Thr Ser Lys Met
         915                 920                 925            
 Met Asp Ala Ile Lys Gly Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser
     930                 935                 940                
 Lys Asn Thr Thr Gly Ser Thr Ile Ala Glu Ile Arg Arg Leu Arg Ile
 945                 950                 955                 960
 Glu Ile Glu Lys Leu Gln Trp Leu His Gln Gln Glu Leu Ser Glu Met
                 965                 970                 975    
 Lys His Asn Leu Glu Leu Thr Met Ala Glu Met Arg Gln Ser Leu Glu
             980                 985                 990        
 Gln Glu Arg Asp Arg Leu Ile Ala Glu Val Lys Lys Gln Leu Glu Leu
         995                1000                1005            
 Glu Lys Gln Gln Ala Val Asp Glu Thr Lys Lys Lys Gln Trp Cys Ala
    1010                1015                1020                
 Asn Cys Lys Lys Glu Ala Ile Phe Tyr Cys Cys Trp Asn Thr Ser Tyr
1025                1030                1035                1040
 Cys Asp Tyr Pro Cys Gln Gln Ala His Trp Pro Glu His Met Lys Ser
                1045                1050                1055    
 Cys Thr Gln Ser Ala Thr Ala Pro Gln Gln Glu Ala Asp Ala Glu Val
            1060                1065                1070        
 Asn Thr Glu Thr Leu Asn Lys Ser Ser Gln Gly Ser Ser Ser Ser Thr
        1075                1080                1085            
 Gln Ser Ala Pro Ser Glu Thr Ala Ser Ala Ser Lys Glu Lys Glu Thr
    1090                1095                1100                
 Ser Ala Glu Lys Ser Lys Glu Ser Gly Ser Thr Leu Asp Leu Ser Gly
1105                1110                1115                1120
 Ser Arg Glu Thr Pro Ser Ser Ile Leu Leu Gly Ser Asn Gln Gly Ser
                1125                1130                1135    
 Asp His Ser Arg Ser Asn Lys Ser Ser Trp Ser Ser Ser Asp Glu Lys
            1140                1145                1150        
 Arg Gly Ser Thr Arg Ser Asp His Asn Thr Ser Thr Ser Thr Lys Ser
        1155                1160                1165            
 Leu Leu Pro Lys Glu Ser Arg Leu Asp Thr Phe Trp Asp
    1170                1175                1180    



      <210> 946
      <211> 1186
      <212> PRT
      <213> Homo sapiens


      <400> 946
 Met Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser Ala Glu Arg Thr
   1               5                  10                  15    
 Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser Ser Asn Gly His
              20                  25                  30        
 Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys Lys Lys Lys Pro
          35                  40                  45            
 Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Ser Glu Leu Arg His Gly
      50                  55                  60                
 Pro Phe Tyr Tyr Met Lys Gln Pro Leu Thr Thr Asp Pro Val Asp Val
  65                  70                  75                  80
 Val Pro Gln Asp Gly Arg Asn Asp Phe Tyr Cys Trp Val Cys His Arg
                  85                  90                  95    
 Glu Gly Gln Val Leu Cys Cys Glu Leu Cys Pro Arg Val Tyr His Ala
             100                 105                 110        
 Lys Cys Leu Arg Leu Thr Ser Glu Pro Glu Gly Asp Trp Phe Cys Pro
         115                 120                 125            
 Glu Cys Glu Lys Ile Thr Val Ala Glu Cys Ile Glu Thr Gln Ser Lys
     130                 135                 140                
 Ala Met Thr Met Leu Thr Ile Glu Gln Leu Ser Tyr Leu Leu Lys Phe
 145                 150                 155                 160
 Ala Ile Gln Lys Met Lys Gln Pro Gly Thr Asp Ala Phe Gln Lys Pro
                 165                 170                 175    
 Val Pro Leu Glu Gln His Pro Asp Tyr Ala Glu Tyr Ile Phe His Pro
             180                 185                 190        
 Met Asp Leu Cys Thr Leu Glu Lys Asn Ala Lys Lys Lys Met Tyr Gly
         195                 200                 205            
 Cys Thr Glu Ala Phe Leu Ala Asp Ala Lys Trp Ile Leu His Asn Cys
     210                 215                 220                
 Ile Ile Tyr Asn Gly Gly Asn His Lys Leu Thr Gln Ile Ala Lys Val
 225                 230                 235                 240
 Val Ile Lys Ile Cys Glu His Glu Met Asn Glu Ile Glu Val Cys Pro
                 245                 250                 255    
 Glu Cys Tyr Leu Ala Ala Cys Gln Lys Arg Asp Asn Trp Phe Cys Glu
             260                 265                 270        
 Pro Cys Ser Asn Pro His Pro Leu Val Trp Ala Lys Leu Lys Gly Phe
         275                 280                 285            
 Pro Phe Trp Pro Ala Lys Ala Leu Arg Asp Lys Asp Gly Gln Val Asp
     290                 295                 300                
 Ala Arg Phe Phe Gly Gln His Asp Arg Ala Trp Val Pro Ile Asn Asn
 305                 310                 315                 320
 Cys Tyr Leu Met Ser Lys Glu Ile Pro Phe Ser Val Lys Lys Thr Lys
                 325                 330                 335    
 Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu Val Tyr Val Glu Asn
             340                 345                 350        
 Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser Pro Phe Arg Thr Pro
         355                 360                 365            
 Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu Asp Pro Thr Asn Pro
     370                 375                 380                
 Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu Lys Val Lys Leu Asn
 385                 390                 395                 400
 Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met Ser Lys Pro Val Leu
                 405                 410                 415    
 Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser Asp Met Pro Arg Ser
             420                 425                 430        
 Pro Met Ser Thr Asn Ser Ser Val His Thr Gly Ser Asp Val Glu Gln
         435                 440                 445            
 Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe Ser Ala Ser Glu Glu
     450                 455                 460                
 Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser Pro Ala Ser Thr Lys
 465                 470                 475                 480
 Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro Lys Pro Phe Ser Pro
                 485                 490                 495    
 Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp Lys Thr Ser Thr Thr
             500                 505                 510        
 Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser Lys Ala Glu Met Asp
         515                 520                 525            
 Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln Ser Thr Pro Val Pro
     530                 535                 540                
 Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg Phe Gln Leu Asn Leu
 545                 550                 555                 560
 Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu Gly Ile Asn Glu Ile
                 565                 570                 575    
 Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser Asp Ser Glu Asp Ser
             580                 585                 590        
 Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile Ser Asp Asp Glu Gln
         595                 600                 605            
 Lys Ser Lys Asn Glu Pro Glu Asp Thr Glu Asp Lys Glu Gly Cys Gln
     610                 615                 620                
 Met Asp Lys Glu Pro Ser Ala Val Lys Lys Lys Pro Lys Pro Thr Asn
 625                 630                 635                 640
 Pro Val Glu Ile Lys Glu Glu Leu Lys Ser Thr Ser Pro Ala Ser Glu
                 645                 650                 655    
 Lys Ala Asp Pro Gly Ala Val Lys Asp Lys Ala Ser Pro Glu Pro Glu
             660                 665                 670        
 Lys Asp Phe Ser Glu Lys Ala Lys Pro Ser Pro His Pro Ile Lys Asp
         675                 680                 685            
 Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser Pro Thr Val His Leu Gly
     690                 695                 700                
 Leu Asp Ser Asp Ser Glu Ser Glu Leu Val Ile Asp Leu Gly Glu Asp
 705                 710                 715                 720
 His Ser Gly Arg Glu Gly Arg Lys Asn Lys Lys Glu Pro Lys Glu Pro
                 725                 730                 735    
 Ser Pro Lys Gln Asp Val Val Gly Lys Thr Pro Pro Ser Thr Thr Val
             740                 745                 750        
 Gly Ser His Ser Pro Pro Glu Thr Pro Val Leu Thr Arg Ser Ser Ala
         755                 760                 765            
 Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr Thr Ser Thr Ser Ser Thr
     770                 775                 780                
 Val Thr Val Thr Ala Pro Ala Pro Ala Ala Thr Gly Ser Pro Val Lys
 785                 790                 795                 800
 Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr Ala Pro Ala Val Gln Arg
                 805                 810                 815    
 Val Val Trp Asn Ser Ser Ser Lys Phe Gln Thr Ser Ser Gln Lys Trp
             820                 825                 830        
 His Met Gln Lys Met Gln Arg Gln Gln Gln Gln Gln Gln Gln Gln Asn
         835                 840                 845            
 Gln Gln Gln Gln Pro Gln Ser Ser Gln Gly Thr Arg Tyr Gln Thr Arg
     850                 855                 860                
 Gln Ala Val Lys Ala Val Gln Gln Lys Glu Ile Thr Gln Ser Pro Ser
 865                 870                 875                 880
 Thr Ser Thr Ile Thr Leu Val Thr Ser Thr Gln Ser Ser Pro Leu Val
                 885                 890                 895    
 Thr Ser Ser Gly Ser Met Ser Thr Leu Val Ser Ser Val Asn Ala Asp
             900                 905                 910        
 Leu Pro Ile Ala Thr Ala Ser Ala Asp Val Ala Ala Asp Ile Ala Lys
         915                 920                 925            
 Tyr Thr Ser Lys Met Met Asp Ala Ile Lys Gly Thr Met Thr Glu Ile
     930                 935                 940                
 Tyr Asn Asp Leu Ser Lys Asn Thr Thr Gly Ser Thr Ile Ala Glu Ile
 945                 950                 955                 960
 Arg Arg Leu Arg Ile Glu Ile Glu Lys Leu Gln Trp Leu His Gln Gln
                 965                 970                 975    
 Glu Leu Ser Glu Met Lys His Asn Leu Glu Leu Thr Met Ala Glu Met
             980                 985                 990        
 Arg Gln Ser Leu Glu Gln Glu Arg Asp Arg Leu Ile Ala Glu Val Lys
         995                1000                1005            
 Lys Gln Leu Glu Leu Glu Lys Gln Gln Ala Val Asp Glu Thr Lys Lys
    1010                1015                1020                
 Lys Gln Trp Cys Ala Asn Cys Lys Lys Glu Ala Ile Phe Tyr Cys Cys
1025                1030                1035                1040
 Trp Asn Thr Ser Tyr Cys Asp Tyr Pro Cys Gln Gln Ala His Trp Pro
                1045                1050                1055    
 Glu His Met Lys Ser Cys Thr Gln Ser Ala Thr Ala Pro Gln Gln Glu
            1060                1065                1070        
 Ala Asp Ala Glu Val Asn Thr Glu Thr Leu Asn Lys Ser Ser Gln Gly
        1075                1080                1085            
 Ser Ser Ser Ser Thr Gln Ser Ala Pro Ser Glu Thr Ala Ser Ala Ser
    1090                1095                1100                
 Lys Glu Lys Glu Thr Ser Ala Glu Lys Ser Lys Glu Ser Gly Ser Thr
1105                1110                1115                1120
 Leu Asp Leu Ser Gly Ser Arg Glu Thr Pro Ser Ser Ile Leu Leu Gly
                1125                1130                1135    
 Ser Asn Gln Gly Ser Asp His Ser Arg Ser Asn Lys Ser Ser Trp Ser
            1140                1145                1150        
 Ser Ser Asp Glu Lys Arg Gly Ser Thr Arg Ser Asp His Asn Thr Ser
        1155                1160                1165            
 Thr Ser Thr Lys Ser Leu Leu Pro Lys Glu Ser Arg Leu Asp Thr Phe
    1170                1175                1180                
 Trp Asp
1185    



      <210> 947
      <211> 471
      <212> PRT
      <213> Homo sapiens


      <400> 947
 Met Val Leu Asp Ser Gly Ala Gln Ala Tyr Asp Gln Ala Pro Pro Ser
   1               5                  10                  15    
 Pro Pro Thr Ser Pro Pro Ser Leu Arg His Arg Leu Lys Pro Ser Asp
              20                  25                  30        
 Arg Asp Gly Pro Pro Leu Tyr Pro Trp Ser Gln Ser Leu Ala Leu Pro
          35                  40                  45            
 Leu Ala Leu Ala Val Pro Pro Ala Leu Gln Pro Gln Pro Glu Gln Gln
      50                  55                  60                
 Pro Phe Ser Gln Met Leu Leu Gly His Arg Gly His Met Arg Arg Ser
  65                  70                  75                  80
 Glu Ser Thr Tyr Ser Val Asn Ser Thr Gly Arg Arg Gly Arg Gly Thr
                  85                  90                  95    
 Leu Gly Arg Pro Pro Pro Gly Arg Gly Arg Asn Pro Gly Gly Gly Thr
             100                 105                 110        
 Leu Arg Pro Ala Ala Ser Leu Pro His Ile Ala Lys Thr Gln Arg Asp
         115                 120                 125            
 Ala Gly His Ile Ala Ser Lys Ser Pro Cys Met Leu Val Ala Leu Arg
     130                 135                 140                
 Pro Thr Asn Met Asp Arg Glu Arg Asp Lys Phe Phe Gln Ser His Tyr
 145                 150                 155                 160
 Thr Tyr Asn Pro Gln Phe Glu Tyr Gln Glu Pro Met Pro Thr Ala Val
                 165                 170                 175    
 Leu Glu Lys Tyr Cys Glu Ala Ser Gly Gln Phe Ile His Gln Ala Val
             180                 185                 190        
 Gly Ile Ile Glu Ala Val Leu Glu Lys Phe Gly Thr Tyr Glu His Phe
         195                 200                 205            
 Glu Ala Ala Thr Gly Gly Gln Leu Leu Thr Lys Cys Gln Ile Trp Ser
     210                 215                 220                
 Ile Val Arg Lys Tyr Met Gln Lys Glu Gly Cys Ala Gly Glu Val Val
 225                 230                 235                 240
 Val Gln Leu Ser Glu Asp Leu Leu Ser Gln Ala Val Met Met Val Glu
                 245                 250                 255    
 Asn Ser Arg Pro Thr Leu Ala Ile Asn Leu Thr Gly Ala Arg Gln Tyr
             260                 265                 270        
 Trp Leu Glu Gly Met Leu Arg His Glu Ile Gly Thr His Tyr Leu Arg
         275                 280                 285            
 Gly Val Asn Asn Ala Arg Gln Pro Trp His Asn Ala Glu Gly Arg Leu
     290                 295                 300                
 Arg Tyr Gly Leu Arg Pro Ala Asn Pro Thr Glu Glu Gly Leu Ala Ser
 305                 310                 315                 320
 Leu His Ser Val Leu Phe Arg Lys Gln Pro Phe Leu Trp Arg Ala Ala
                 325                 330                 335    
 Leu Leu Tyr Tyr Thr Ile His Arg Ala Ala Arg Met Ser Phe Arg Gln
             340                 345                 350        
 Leu Phe Gln Asp Leu Glu Arg Tyr Val Gln Asp Ala Asp Val Arg Trp
         355                 360                 365            
 Glu Tyr Cys Val Arg Ala Lys Arg Gly Gln Thr Asp Thr Ser Leu Pro
     370                 375                 380                
 Gly Cys Phe Ser Lys Asp Gln Val Tyr Leu Asn Gly Ile Leu Cys Ile
 385                 390                 395                 400
 Leu Gly His Arg Gln Thr Ile Asp Phe Pro Leu Leu Thr Ser Leu Gly
                 405                 410                 415    
 Lys Val Ser Tyr Glu Asp Val Asp His Leu Arg Pro His Gly Val Leu
             420                 425                 430        
 Asp Asn Thr Arg Met Pro His Leu Met Gln Asp Leu Ala Arg Tyr Arg
         435                 440                 445            
 Gln Gln Leu Lys His Ile Met Ala Thr Asn Arg Leu Asp Val Ala Glu
     450                 455                 460                
 Leu Gly Arg Leu Leu Pro Asp
 465                 470    



      <210> 948
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 948
 Met Leu Leu Tyr Leu Tyr Ser Leu Gly Ile Ser Val Leu Ile Ile Ser
   1               5                  10                  15    
 Phe Pro Thr Asn Ser Ser Ile His Val Arg Lys Asn Met Ala Asn Gln
              20                  25                  30        
 Tyr Leu Lys Gly Ala Ile Phe Gln Ser Ser Gly Phe Gln Ser Val Ala
          35                  40                  45            
 Gly Gln His Trp Gln His Leu Asn Leu Leu Gly Leu Cys
      50                  55                  60    



      <210> 949
      <211> 336
      <212> PRT
      <213> Homo sapiens


      <400> 949
 Met Arg Asp Ile Glu Arg His Phe Gly Cys Met Val Ser Glu Arg Val
   1               5                  10                  15    
 Lys Gln Glu Ala Leu Arg Trp Val Gln Gly Gln Gly Gln Gly Cys Pro
              20                  25                  30        
 Gly Val Ala Pro Glu Val Thr Glu Gly Ala Lys Gly Leu Glu Asp Thr
          35                  40                  45            
 Glu Glu Pro Glu Glu Glu Glu Glu Gly Glu Glu Pro Asn Tyr Pro Leu
      50                  55                  60                
 Glu Leu Leu Tyr Cys Leu Tyr Glu Thr Gln Glu Asp Ala Phe Val Arg
  65                  70                  75                  80
 Gln Ala Leu Cys Arg Phe Pro Glu Leu Ala Leu Gln Arg Val Arg Phe
                  85                  90                  95    
 Cys Arg Met Asp Val Ala Val Leu Ser Tyr Cys Val Arg Cys Cys Pro
             100                 105                 110        
 Ala Gly Gln Ala Leu Arg Leu Ile Ser Cys Arg Leu Val Ala Ala Gln
         115                 120                 125            
 Glu Lys Lys Lys Lys Ser Leu Gly Lys Arg Leu Gln Ala Ser Leu Gly
     130                 135                 140                
 Gly Gly Ser Ser Gln Gly Thr Thr Lys Gln Leu Pro Ala Ser Leu Leu
 145                 150                 155                 160
 His Pro Leu Phe Gln Ala Met Thr Asp Pro Leu Cys His Leu Ser Ser
                 165                 170                 175    
 Leu Thr Leu Ser His Cys Lys Leu Pro Asp Ala Val Cys Arg Asp Leu
             180                 185                 190        
 Ser Glu Ala Leu Arg Ala Ala Pro Ala Leu Thr Glu Leu Gly Leu Leu
         195                 200                 205            
 His Asn Arg Leu Ser Glu Ala Gly Leu Arg Met Leu Ser Glu Gly Leu
     210                 215                 220                
 Ala Trp Pro Gln Cys Arg Val Gln Thr Val Arg Val Gln Leu Pro Asp
 225                 230                 235                 240
 Pro Gln Arg Gly Leu Gln Tyr Leu Val Gly Met Leu Arg Gln Ser Pro
                 245                 250                 255    
 Ala Leu Thr Thr Leu Asp Leu Ser Gly Cys Gln Leu Pro Ala Pro Met
             260                 265                 270        
 Val Thr Tyr Leu Cys Ala Val Leu Gln His Gln Gly Cys Gly Leu Gln
         275                 280                 285            
 Thr Leu Ser Leu Ala Ser Val Glu Leu Ser Glu Gln Ser Leu Gln Glu
     290                 295                 300                
 Leu Gln Ala Val Lys Arg Ala Lys Pro Asp Leu Val Ile Ala His Pro
 305                 310                 315                 320
 Ala Leu Asp Gly His Pro Gln Pro Pro Lys Glu Leu Ile Ser Thr Phe
                 325                 330                 335    





      <210> 950
      <211> 1430
      <212> PRT
      <213> Homo sapiens


      <400> 950
 Met Thr Ser Val Asp His Gly Arg Ala Ala Gln Ala Gly Gly Ala Asp
   1               5                  10                  15    
 Gly Pro Trp Ala Gln Arg Leu Asp Ala Gly Gly Pro Ser Ser Ala Cys
              20                  25                  30        
 Ala Leu Leu Pro Ala Lys Asp Pro Glu Pro Pro Glu Pro Pro Pro Thr
          35                  40                  45            
 Thr Glu Pro Ser Gln Gly Cys Arg Ala Arg Trp Arg Arg Ala Trp Ala
      50                  55                  60                
 Phe Leu Ala Ile Asp Glu Pro Arg Pro Val Phe Arg Ser Phe Glu Gly
  65                  70                  75                  80
 Ser Glu Gly Arg Gly Gly Ser Gly Ser Leu Asp Pro Arg Pro Pro Tyr
                  85                  90                  95    
 Pro Ala Pro Pro Ser Gln Pro Gly Pro Glu Pro Pro Arg Val Pro Ala
             100                 105                 110        
 Arg Pro Ala Gly Gly Ala Arg Gly Gln Thr Pro Ala Pro Asp Pro Gly
         115                 120                 125            
 Thr Gly Val Phe Ser Ser Leu Ile Cys Glu Glu Lys Lys Asn Val Phe
     130                 135                 140                
 Gln Gly Asn Ala Arg Glu Glu Gly Gly Gly Ser His Ser Leu Leu Pro
 145                 150                 155                 160
 Arg Val Gly Ser Glu Leu Pro Gly Arg Met Pro Leu Pro Asp Gly Ala
                 165                 170                 175    
 Arg Thr Pro Gly Gly Val Cys Arg Glu Ala Arg Gly Gly Gly Tyr Thr
             180                 185                 190        
 Asn Arg Thr Phe Glu Phe Asp Asp Gly Gln Cys Ala Pro Arg Arg Pro
         195                 200                 205            
 Cys Ala Gly Asp Gly Ala Leu Leu Asp Thr Ala Gly Phe Lys Met Ser
     210                 215                 220                
 Asp Leu Asp Ser Glu Val Leu Pro Leu Pro Pro Arg Tyr Arg Phe Arg
 225                 230                 235                 240
 Asp Leu Leu Leu Gly Asp Pro Ser Phe Gln Asn Asp Asp Arg Val Gln
                 245                 250                 255    
 Val Glu Phe Tyr Val Asn Glu Asn Thr Phe Lys Glu Arg Leu Lys Leu
             260                 265                 270        
 Phe Phe Ile Lys Asn Gln Arg Ser Ser Leu Arg Ile Arg Leu Phe Asn
         275                 280                 285            
 Phe Ser Leu Lys Leu Leu Thr Cys Leu Leu Tyr Ile Val Arg Val Leu
     290                 295                 300                
 Leu Asp Asp Pro Ala Leu Gly Ile Gly Cys Trp Gly Cys Pro Lys Gln
 305                 310                 315                 320
 Asn Tyr Ser Phe Asn Asp Ser Ser Ser Glu Ile Asn Trp Ala Pro Ile
                 325                 330                 335    
 Leu Trp Val Glu Arg Lys Met Thr Leu Trp Ala Ile Gln Val Ile Val
             340                 345                 350        
 Ala Ile Ile Ser Phe Leu Glu Thr Met Leu Leu Ile Tyr Leu Ser Tyr
         355                 360                 365            
 Lys Gly Asn Ile Trp Glu Gln Ile Phe Arg Val Ser Phe Val Leu Glu
     370                 375                 380                
 Met Ile Asn Thr Leu Pro Phe Ile Ile Thr Ile Phe Trp Pro Pro Leu
 385                 390                 395                 400
 Arg Asn Leu Phe Ile Pro Val Phe Leu Asn Cys Trp Leu Ala Lys His
                 405                 410                 415    
 Ala Leu Glu Asn Met Ile Asn Asp Phe His Arg Ala Ile Leu Arg Thr
             420                 425                 430        
 Gln Ser Ala Met Phe Asn Gln Val Leu Ile Leu Phe Cys Thr Leu Leu
         435                 440                 445            
 Cys Leu Val Phe Thr Gly Thr Cys Gly Ile Gln His Leu Glu Arg Ala
     450                 455                 460                
 Gly Glu Asn Leu Ser Leu Leu Thr Ser Phe Tyr Phe Cys Ile Val Thr
 465                 470                 475                 480
 Phe Ser Thr Val Gly Tyr Gly Asp Val Thr Pro Lys Ile Trp Pro Ser
                 485                 490                 495    
 Gln Leu Leu Val Val Ile Met Ile Cys Val Ala Leu Val Val Leu Pro
             500                 505                 510        
 Leu Gln Phe Glu Glu Leu Val Tyr Leu Trp Met Glu Arg Gln Lys Ser
         515                 520                 525            
 Gly Gly Asn Tyr Ser Arg His Arg Ala Gln Thr Glu Lys His Val Val
     530                 535                 540                
 Leu Cys Val Ser Ser Leu Lys Ile Asp Leu Leu Met Asp Phe Leu Asn
 545                 550                 555                 560
 Glu Phe Tyr Ala His Pro Arg Leu Gln Asp Tyr Tyr Val Val Ile Leu
                 565                 570                 575    
 Cys Pro Thr Glu Met Asp Val Gln Val Arg Arg Val Leu Gln Ile Pro
             580                 585                 590        
 Leu Trp Ser Gln Arg Val Ile Tyr Leu Gln Gly Ser Ala Leu Lys Asp
         595                 600                 605            
 Gln Asp Leu Met Arg Ala Lys Met Asp Asn Gly Glu Ala Cys Phe Ile
     610                 615                 620                
 Leu Ser Ser Arg Asn Glu Val Asp Arg Thr Ala Ala Asp His Gln Thr
 625                 630                 635                 640
 Ile Leu Arg Ala Trp Ala Val Lys Asp Phe Ala Pro Asn Cys Pro Leu
                 645                 650                 655    
 Tyr Val Gln Ile Leu Lys Pro Glu Asn Lys Phe His Val Lys Phe Ala
             660                 665                 670        
 Asp His Val Val Cys Glu Glu Glu Cys Lys Tyr Ala Met Leu Ala Leu
         675                 680                 685            
 Asn Cys Ile Cys Pro Ala Thr Ser Thr Leu Ile Thr Leu Leu Val His
     690                 695                 700                
 Thr Ser Arg Gly Gln Glu Gly Gln Glu Ser Pro Glu Gln Trp Gln Arg
 705                 710                 715                 720
 Met Tyr Gly Arg Cys Ser Gly Asn Glu Val Tyr His Ile Arg Met Gly
                 725                 730                 735    
 Asp Ser Lys Phe Phe Arg Glu Tyr Glu Gly Lys Ser Phe Thr Tyr Ala
             740                 745                 750        
 Ala Phe His Ala His Lys Lys Tyr Gly Val Cys Leu Ile Gly Leu Lys
         755                 760                 765            
 Arg Glu Asp Asn Lys Ser Ile Leu Leu Asn Pro Gly Pro Arg His Ile
     770                 775                 780                
 Leu Ala Ala Ser Asp Thr Cys Phe Tyr Ile Asn Ile Thr Lys Glu Glu
 785                 790                 795                 800
 Asn Ser Ala Phe Ile Phe Lys Gln Glu Glu Lys Arg Lys Lys Arg Ala
                 805                 810                 815    
 Phe Ser Gly Gln Gly Leu His Glu Gly Pro Ala Arg Leu Pro Val His
             820                 825                 830        
 Ser Ile Ile Ala Ser Met Gly Thr Val Ala Met Asp Leu Gln Gly Thr
         835                 840                 845            
 Glu His Arg Pro Thr Gln Ser Gly Gly Gly Gly Gly Gly Ser Lys Leu
     850                 855                 860                
 Ala Leu Pro Thr Glu Asn Gly Ser Gly Ser Arg Arg Pro Ser Ile Ala
 865                 870                 875                 880
 Pro Val Leu Glu Leu Ala Asp Ser Ser Ala Leu Leu Pro Cys Asp Leu
                 885                 890                 895    
 Leu Ser Asp Gln Ser Glu Asp Glu Val Thr Pro Ser Asp Asp Glu Gly
             900                 905                 910        
 Leu Ser Val Val Glu Tyr Val Lys Gly Tyr Pro Pro Asn Ser Pro Tyr
         915                 920                 925            
 Ile Gly Ser Ser Pro Thr Leu Cys His Leu Leu Pro Val Lys Ala Pro
     930                 935                 940                
 Phe Cys Cys Leu Arg Leu Asp Lys Gly Cys Lys His Asn Ser Tyr Glu
 945                 950                 955                 960
 Asp Ala Lys Ala Tyr Gly Phe Lys Asn Lys Leu Ile Ile Val Ser Ala
                 965                 970                 975    
 Glu Thr Ala Gly Asn Gly Leu Tyr Asn Phe Ile Val Pro Leu Arg Ala
             980                 985                 990        
 Tyr Tyr Arg Ser Arg Lys Glu Leu Asn Pro Ile Val Leu Leu Leu Asp
         995                1000                1005            
 Asn Lys Pro Asp His His Phe Leu Glu Ala Ile Cys Cys Phe Pro Met
    1010                1015                1020                
 Val Tyr Tyr Met Glu Gly Ser Val Asp Asn Leu Asp Ser Leu Leu Gln
1025                1030                1035                1040
 Cys Gly Ile Ile Tyr Ala Asp Asn Leu Val Val Val Asp Lys Glu Ser
                1045                1050                1055    
 Thr Met Ser Ala Glu Glu Asp Tyr Met Ala Asp Ala Lys Thr Ile Val
            1060                1065                1070        
 Asn Val Gln Thr Met Phe Arg Leu Phe Pro Ser Leu Ser Ile Thr Thr
        1075                1080                1085            
 Glu Leu Thr His Pro Ser Asn Met Arg Phe Met Gln Phe Arg Ala Lys
    1090                1095                1100                
 Asp Ser Tyr Ser Leu Ala Leu Ser Lys Leu Glu Lys Arg Glu Arg Glu
1105                1110                1115                1120
 Asn Gly Ser Asn Leu Ala Phe Met Phe Arg Leu Pro Phe Ala Ala Gly
                1125                1130                1135    
 Arg Val Phe Ser Ile Ser Met Leu Asp Thr Leu Leu Tyr Gln Ser Phe
            1140                1145                1150        
 Val Lys Asp Tyr Met Ile Thr Ile Thr Arg Leu Leu Leu Gly Leu Asp
        1155                1160                1165            
 Thr Thr Pro Gly Ser Gly Tyr Leu Cys Ala Met Lys Ile Thr Glu Gly
    1170                1175                1180                
 Asp Leu Trp Ile Arg Thr Tyr Gly Arg Leu Phe Gln Lys Leu Cys Ser
1185                1190                1195                1200
 Ser Ser Ala Glu Ile Pro Ile Gly Ile Tyr Arg Thr Glu Ser His Val
                1205                1210                1215    
 Phe Ser Thr Ser Glu Val Leu Gly Gln Pro Gly Gly Trp Asp Cys Gly
            1220                1225                1230        
 Ser Pro Cys Pro Ser Gln Ile Ser Val Asn Val Glu Asp Cys Glu Asp
        1235                1240                1245            
 Thr Arg Glu Val Lys Gly Pro Trp Gly Ser Arg Ala Gly Thr Gly Gly
    1250                1255                1260                
 Ser Ser Gln Gly Arg His Thr Gly Gly Gly Asp Pro Ala Glu His Pro
1265                1270                1275                1280
 Leu Leu Arg Arg Lys Ser Leu Gln Trp Ala Arg Arg Leu Ser Arg Lys
                1285                1290                1295    
 Ala Pro Lys Gln Ala Gly Arg Ala Ala Ala Ala Glu Trp Ile Ser Gln
            1300                1305                1310        
 Gln Arg Leu Ser Leu Tyr Arg Arg Ser Glu Arg Gln Glu Leu Ser Glu
        1315                1320                1325            
 Leu Val Lys Asn Arg Met Lys His Leu Gly Leu Pro Thr Thr Gly Tyr
    1330                1335                1340                
 Glu Asp Val Ala Asn Leu Thr Ala Ser Asp Val Met Asn Arg Val Asn
1345                1350                1355                1360
 Leu Gly Tyr Leu Gln Gly Asn Ser Ala Leu Ala Gly Ala Asp His Arg
                1365                1370                1375    
 Thr Thr Gly Leu Ala Asn Pro Ser Pro Pro Ala Ala Leu Leu Arg His
            1380                1385                1390        
 Pro Gly Gln Ala Gly Pro Gln Ala His Leu Leu Pro Ala Phe Thr Lys
        1395                1400                1405            
 His Arg Gly His Ala Lys Leu Val Leu Cys Asp His Pro Gly Gln Pro
    1410                1415                1420                
 Gly Pro Val Pro Cys Asp
1425                1430



      <210> 951
      <211> 787
      <212> PRT
      <213> Homo sapiens


      <400> 951
 Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu
   1               5                  10                  15    
 Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln
              20                  25                  30        
 Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly
          35                  40                  45            
 Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp
      50                  55                  60                
 Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu
  65                  70                  75                  80
 Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His
                  85                  90                  95    
 Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp
             100                 105                 110        
 His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val
         115                 120                 125            
 Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg
     130                 135                 140                
 Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp
 145                 150                 155                 160
 Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys
                 165                 170                 175    
 Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser
             180                 185                 190        
 Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr
         195                 200                 205            
 Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu
     210                 215                 220                
 Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val
 225                 230                 235                 240
 Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala
                 245                 250                 255    
 Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val Thr
             260                 265                 270        
 Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg Gly
         275                 280                 285            
 Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly Arg
     290                 295                 300                
 Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met Cys
 305                 310                 315                 320
 Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu Pro
                 325                 330                 335    
 Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu Gly
             340                 345                 350        
 Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu Ser
         355                 360                 365            
 Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg Val
     370                 375                 380                
 Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys Gly
 385                 390                 395                 400
 Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val Pro
                 405                 410                 415    
 Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp
             420                 425                 430        
 Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His Asn
         435                 440                 445            
 Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys Val
     450                 455                 460                
 Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met Gly
 465                 470                 475                 480
 Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys Pro
                 485                 490                 495    
 Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly
             500                 505                 510        
 Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln
         515                 520                 525            
 Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln Val
     530                 535                 540                
 Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser Glu
 545                 550                 555                 560
 Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu
                 565                 570                 575    
 Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val Pro
             580                 585                 590        
 Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg Gly
         595                 600                 605            
 Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu
     610                 615                 620                
 Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Asn Ser Asn
 625                 630                 635                 640
 His Asn Cys His Cys Ala Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys
                 645                 650                 655    
 Pro Gly Phe Gly Gly Ser Met Asp Ser Gly Pro Val Gln Ala Glu Asn
             660                 665                 670        
 His Asp Thr Phe Leu Leu Ala Met Leu Leu Ser Val Leu Leu Pro Leu
         675                 680                 685            
 Leu Pro Gly Ala Gly Leu Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala
     690                 695                 700                
 His Leu Gln Arg Cys Ser Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser
 705                 710                 715                 720
 Gly Pro Lys Asp Gly Pro His Arg Asp His Pro Leu Gly Gly Val His
                 725                 730                 735    
 Pro Met Glu Leu Gly Pro Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp
             740                 745                 750        
 Pro Glu Asn Ser His Glu Pro Ser Ser His Pro Glu Lys Pro Leu Pro
         755                 760                 765            
 Ala Val Ser Pro Asp Pro Gln Ala Asp Gln Val Gln Met Pro Arg Ser
     770                 775                 780                
 Cys Leu Trp
 785        



      <210> 952
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 952
 Met Ala Pro Ser Arg Leu Gln Leu Gly Leu Arg Ala Ala Tyr Ser Gly
   1               5                  10                  15    
 Ile Ser Ser Val Ala Gly Phe Ser Ile Phe Leu Val Trp Thr Val Val
              20                  25                  30        
 Tyr Arg Gln Pro Gly Thr Ala Ala Met Gly Gly Leu Ala Gly Val Leu
          35                  40                  45            
 Ala Leu Trp Val Leu Val Thr His Val Met Tyr Met Gln Asp Tyr Trp
      50                  55                  60                
 Arg Thr Trp Leu Lys Gly Leu Arg Gly Phe Phe Phe Val Gly Val Leu
  65                  70                  75                  80
 Phe Ser Ala Val Ser Ile Ala Ala Phe Cys Thr Phe Leu Val Leu Ala
                  85                  90                  95    
 Ile Thr Arg His Gln Ser Leu Thr Asp Pro Thr Ser Tyr Tyr Leu Ser
             100                 105                 110        
 Ser Val Trp Ser Phe Ile Ser Phe Lys Trp Ala Phe Leu Leu Ser Leu
         115                 120                 125            
 Tyr Ala His Arg Tyr Arg Ala Asp Phe Ala Asp Ile Ser Ile Leu Ser
     130                 135                 140                
 Asp Phe
 145    



      <210> 953
      <211> 504
      <212> PRT
      <213> Homo sapiens


      <400> 953
 Met Ala Leu Gln Asn Ala Leu Tyr Thr Gly Asp Leu Ala Arg Leu Gln
   1               5                  10                  15    
 Glu Leu Phe Pro Pro His Ser Thr Ala Asp Leu Leu Leu Glu Ser Arg
              20                  25                  30        
 Ala Ala Glu Pro Arg Trp Ser Ser His Gln Arg Glu Glu Cys Lys Gly
          35                  40                  45            
 Gln Gly Glu Pro Leu Asp Asp Arg His Pro Leu Cys Ala Arg Leu Val
      50                  55                  60                
 Glu Lys Pro Ser Arg Gly Ser Glu Glu His Leu Lys Ser Gly Pro Gly
  65                  70                  75                  80
 Pro Ile Val Thr Arg Thr Ala Ser Gly Pro Ala Leu Ala Phe Trp Gln
                  85                  90                  95    
 Ala Val Leu Ala Gly Asp Val Gly Cys Val Ser Arg Ile Leu Ala Asp
             100                 105                 110        
 Ser Ser Thr Gly Leu Ala Pro Asp Ser Val Phe Asp Thr Ser Asp Pro
         115                 120                 125            
 Glu Arg Trp Arg Asp Phe Arg Phe Asn Ile Arg Ala Leu Arg Leu Trp
     130                 135                 140                
 Ser Leu Thr Tyr Glu Glu Glu Leu Thr Thr Pro Leu His Val Ala Ala
 145                 150                 155                 160
 Ser Arg Gly His Thr Glu Val Leu Arg Leu Leu Leu Arg Arg Arg Ala
                 165                 170                 175    
 Arg Pro Asp Ser Ala Pro Gly Gly Arg Thr Ala Leu His Glu Ala Cys
             180                 185                 190        
 Ala Ala Gly His Thr Ala Cys Val His Val Leu Leu Val Ala Gly Ala
         195                 200                 205            
 Asp Pro Asn Ile Ala Asp Gln Asp Gly Lys Arg Pro Leu His Leu Cys
     210                 215                 220                
 Arg Gly Pro Gly Thr Leu Glu Cys Ala Glu Leu Leu Leu Arg Phe Gly
 225                 230                 235                 240
 Ala Arg Val Asp Gly Arg Ser Glu Glu Glu Glu Glu Thr Pro Leu His
                 245                 250                 255    
 Val Ala Ala Arg Leu Gly His Val Glu Leu Ala Asp Leu Leu Leu Arg
             260                 265                 270        
 Arg Gly Ala Cys Pro Asp Ala Arg Asn Ala Glu Gly Trp Thr Pro Leu
         275                 280                 285            
 Leu Ala Ala Cys Asp Val Arg Cys Gln Ser Ile Thr Asp Ala Glu Ala
     290                 295                 300                
 Thr Thr Ala Arg Cys Leu Gln Leu Cys Ser Leu Leu Leu Ser Ala Gly
 305                 310                 315                 320
 Ala Asp Ala Asp Ala Ala Asp Gln Asp Lys Gln Arg Pro Leu His Leu
                 325                 330                 335    
 Ala Cys Arg Arg Gly His Ala Ala Val Val Glu Leu Leu Leu Ser Cys
             340                 345                 350        
 Gly Val Ser Ala Asn Thr Met Asp Tyr Gly Gly His Thr Pro Leu His
         355                 360                 365            
 Cys Ala Leu Gln Gly Pro Ala Ala Ala Leu Ala Gln Ser Pro Glu His
     370                 375                 380                
 Val Val Arg Ala Leu Leu Asn His Gly Ala Val Arg Val Trp Pro Gly
 385                 390                 395                 400
 Ala Leu Pro Lys Val Val Leu Glu Arg Trp Ser Thr Cys Pro Arg Thr
                 405                 410                 415    
 Ile Glu Val Leu Met Asn Thr Tyr Ser Val Val Gln Leu Pro Glu Glu
             420                 425                 430        
 Ala Val Gly Leu Val Thr Pro Glu Thr Leu Gln Lys His Gln Arg Phe
         435                 440                 445            
 Tyr Ser Ser Leu Phe Ala Leu Val Arg Gln Pro Arg Ser Leu Gln His
     450                 455                 460                
 Leu Ser Arg Cys Ala Leu Arg Ser His Leu Glu Gly Ser Leu Pro Gln
 465                 470                 475                 480
 Ala Leu Pro Arg Leu Pro Leu Pro Pro Arg Leu Leu Arg Tyr Leu Gln
                 485                 490                 495    
 Leu Asp Phe Glu Gly Val Leu Tyr
             500                



      <210> 954
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 954
 Met Lys Thr Ser Ala Gln Pro Gly Gln Lys His Pro Asp Phe Ser Met
   1               5                  10                  15    
 Ala Leu Leu Phe Pro Leu Leu Ala Ala Leu Glu Val Cys Ser Cys Gly
              20                  25                  30        
 Ser Ser Gly Ser Leu Gly Tyr Asn Leu Pro Gln Asn His Gly Leu Leu
          35                  40                  45            
 Gly Arg Asn Thr Leu Val Leu Leu Gly Gln Met Arg Arg Ile Ser Pro
      50                  55                  60                
 Phe Leu Cys Leu Lys Asp Arg Ser Asp Phe Arg Phe Pro Gln Glu Lys
  65                  70                  75                  80
 Val Glu Val Ile Gln Leu Gln Lys Ala His Ala Met Ser Phe Leu Tyr
                  85                  90                  95    
 Asp Val Leu Gln Gln Val Phe Asn Phe Ser His Lys Ala Leu Leu Cys
             100                 105                 110        
 Cys Met Glu His Asp Leu Pro Gly Pro Thr Pro His Phe Thr Ser Ser
         115                 120                 125            
 Ala Ala Gly Thr Pro Gly Asp Leu Leu Gly Ala Gly Asp Gly Arg Arg
     130                 135                 140                
 Arg Ser Trp Gly Gln Trp Val Ile Glu Gly Ser Thr Leu Ala Leu Arg
 145                 150                 155                 160
 Arg Tyr Phe Gln Glu Ser Ile Ser Thr Leu Glu
                 165                 170    



      <210> 955
      <211> 292
      <212> PRT
      <213> Homo sapiens


      <400> 955
 Met Ala Ser Pro Ser Ala His His Asn Val Trp Ile Lys Gln Met Lys
   1               5                  10                  15    
 Asn Lys Asn Met Met Ala Ser Pro Ser Lys Ala Pro Gly Leu Glu Arg
              20                  25                  30        
 Val Pro Trp Gln Gly Ile Gly Thr Pro Ser Cys Pro Ser Ser Leu Ser
          35                  40                  45            
 Asp Cys Leu Leu Glu Met Pro Pro Ser Pro Phe Glu Ser Ser Ser Trp
      50                  55                  60                
 Ala Thr Pro Val Thr Cys Asn Leu Cys Pro Glu Ile Ile Thr Met Ala
  65                  70                  75                  80
 Arg Val Ala Ser Ala Gln Gly Leu Cys Asp Ile Thr Lys Gly Leu Ala
                  85                  90                  95    
 Pro Gly Ala Gln Ser Ser Ser Cys Glu Gly Lys Gln Thr Arg His Glu
             100                 105                 110        
 Gln Leu Pro Ser Pro Ser Leu Leu Thr Met Trp Thr Leu Lys Ser Ser
         115                 120                 125            
 Leu Val Leu Leu Leu Cys Leu Thr Cys Ser Tyr Ala Phe Met Phe Ser
     130                 135                 140                
 Ser Leu Arg Gln Lys Thr Ser Glu Pro Gln Gly Lys Val Gln Tyr Gly
 145                 150                 155                 160
 Glu His Phe Arg Ile Arg Gln Asn Leu Pro Glu His Thr Gln Gly Trp
                 165                 170                 175    
 Leu Gly Ser Lys Trp Leu Trp Leu Leu Phe Val Val Val Pro Phe Val
             180                 185                 190        
 Ile Leu Gln Cys Gln Arg Asp Ser Glu Lys Asn Lys Glu Gln Ser Pro
         195                 200                 205            
 Pro Gly Leu Arg Gly Gly Gln Leu His Ser Pro Leu Lys Lys Lys Arg
     210                 215                 220                
 Asn Ala Ser Pro Asn Lys Asp Cys Ala Phe Asn Thr Leu Met Glu Leu
 225                 230                 235                 240
 Glu Val Glu Leu Met Lys Phe Val Ser Lys Val Arg Asn Leu Lys Arg
                 245                 250                 255    
 Ala Met Ala Thr Gly Ser Gly Ser Asn Leu Arg Leu Arg Lys Ser Glu
             260                 265                 270        
 Met Pro Ala Asp Pro Tyr His Val Thr Ile Cys Glu Ile Trp Gly Glu
         275                 280                 285            
 Glu Ser Ser Ser
     290        



      <210> 956
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 956
 Met His Lys Ala Gly Leu Leu Gly Leu Cys Ala Arg Ala Trp Asn Ser
   1               5                  10                  15    
 Val Arg Met Ala Ser Ser Gly Met Thr Arg Arg Asp Pro Leu Ala Asn
              20                  25                  30        
 Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile
          35                  40                  45            
 Ala Arg Arg Leu Ala Gln Asp Gly Ala His Val Val Val Ser Ser Arg
      50                  55                  60                
 Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly
  65                  70                  75                  80
 Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg
                  85                  90                  95    
 Glu Arg Leu Val Ala Thr Ala Val Lys Leu His Gly Gly Ile Asp Ile
             100                 105                 110        
 Leu Val Ser Asn Ala Ala Val Asn Pro Phe Phe Gly Ser Ile Met Asp
         115                 120                 125            
 Val Thr Glu Glu Val Trp Asp Lys Leu Trp Met Asp Lys Glu Lys Glu
     130                 135                 140                
 Glu Ser Met Lys Glu Thr Leu Arg Ile Arg Arg Leu Gly Glu Pro Glu
 145                 150                 155                 160
 Asp Cys Ala Gly Ile Val Ser Phe Leu Cys Ser Glu Asp Ala Ser Tyr
                 165                 170                 175    
 Ile Thr Gly Glu Thr Val Val Val Gly Gly Gly Thr Pro Ser Arg Leu
             180                 185                 190        





      <210> 957
      <211> 481
      <212> PRT
      <213> Homo sapiens


      <400> 957
 Met Gln Ala Gln Asp Gly Leu Gln Val Ser Pro Ala Gln Asp Gly His
   1               5                  10                  15    
 Gln Val Thr Leu Ala Gln Asp Gly Leu Gln Val Thr Gln Thr Gln Asp
              20                  25                  30        
 Glu Leu His Val Thr Gln Ala Gln Asp Trp Leu Gln Val Ser Leu Ala
          35                  40                  45            
 Gln Asp Gly Leu Gln Met Cys Thr Pro Asp Ala Gly Asn Ser Pro Asp
      50                  55                  60                
 Trp Ala Ser Ala Ile Arg Val Ala Ala Leu Asp Cys Met Glu Glu Lys
  65                  70                  75                  80
 Asn Gln Ala Val Cys His Asp Tyr Asp Ile His Phe Tyr Pro Thr Phe
                  85                  90                  95    
 Arg Ala Gly Thr Gly Leu Leu Ser Leu Gly Val Cys Leu Pro His Glu
             100                 105                 110        
 Asp Ser Arg Thr His Ser Ser Asp Pro Gly Val Leu Pro Ala Gly Pro
         115                 120                 125            
 Asp Arg Glu Leu Arg Thr Val Arg Gln Thr Met Ile Asp Phe Leu Gln
     130                 135                 140                
 Asn His Thr Glu Gly Ser Arg Pro Pro Ala Cys Pro Arg Leu Asp Pro
 145                 150                 155                 160
 Ile Gln Pro Ser Asp Val Leu Ser Leu Leu Asp Asn Arg Gly Ser His
                 165                 170                 175    
 Tyr Val Ala Ile Val Phe Glu Ser Asn Ser Ser Tyr Leu Gly Arg Glu
             180                 185                 190        
 Val Ile Leu Asp Leu Ile Pro Tyr Glu Ser Ile Val Val Thr Arg Ala
         195                 200                 205            
 Leu Asp Gly Asp Lys Ala Phe Leu Glu Lys Leu Gly Val Ser Ser Val
     210                 215                 220                
 Pro Ser Cys Tyr Leu Ile Tyr Pro Asn Gly Ser His Gly Leu Ile Asn
 225                 230                 235                 240
 Val Ser Lys Leu Tyr Thr Val Asp Leu Glu Ser Gly Leu His Tyr Leu
                 245                 250                 255    
 Leu Arg Val Glu Leu Ala Ala His Lys Ser Leu Ala Gly Ala Glu Leu
             260                 265                 270        
 Lys Thr Leu Lys Asp Phe Val Thr Val Leu Ala Lys Leu Phe Pro Gly
         275                 280                 285            
 Arg Pro Pro Val Lys Lys Leu Leu Glu Met Leu Gln Glu Trp Leu Ala
     290                 295                 300                
 Ser Leu Pro Leu Asp Arg Ile Pro Tyr Asn Ala Val Leu Asp Leu Val
 305                 310                 315                 320
 Asn Asn Lys Met Arg Ile Ser Gly Ile Phe Leu Thr Asn His Ile Lys
                 325                 330                 335    
 Trp Val Gly Cys Gln Gly Ser Arg Ser Glu Leu Arg Gly Tyr Pro Cys
             340                 345                 350        
 Ser Leu Trp Lys Leu Phe His Thr Leu Thr Val Glu Ala Ser Thr His
         355                 360                 365            
 Pro Asp Ala Leu Val Gly Thr Gly Phe Glu Asp Asp Pro Gln Ala Val
     370                 375                 380                
 Leu Gln Thr Met Arg Arg Tyr Val His Thr Phe Phe Gly Cys Lys Glu
 385                 390                 395                 400
 Cys Gly Glu His Phe Glu Glu Met Ala Lys Glu Ser Met Asp Ser Val
                 405                 410                 415    
 Lys Thr Pro Asp Gln Ala Ile Leu Trp Leu Trp Lys Lys His Asn Met
             420                 425                 430        
 Val Asn Gly Arg Leu Ala Gly Glu Lys Pro Leu Gly Met Gly Gly Ser
         435                 440                 445            
 Ala Arg Ala Glu Gly Gly Pro Gly Pro Gly Thr Ala Arg Thr Ala Arg
     450                 455                 460                
 Leu Pro Trp Gly Leu Ser Leu Ser Phe Ala Ala Ser Cys His Pro Leu
 465                 470                 475                 480
 Cys
    



      <210> 958
      <211> 426
      <212> PRT
      <213> Homo sapiens


      <400> 958
 Met Ala Gly Leu Gly Phe Trp Gly His Pro Ala Gly Pro Leu Leu Leu
   1               5                  10                  15    
 Leu Leu Leu Leu Val Leu Pro Pro Arg Ala Leu Pro Glu Gly Pro Leu
              20                  25                  30        
 Val Phe Val Ala Leu Val Phe Arg His Gly Asp Arg Ala Pro Leu Ala
          35                  40                  45            
 Ser Tyr Pro Met Asp Pro His Lys Glu Val Ala Ser Thr Leu Trp Pro
      50                  55                  60                
 Arg Gly Leu Gly Gln Leu Thr Thr Glu Gly Val Arg Gln Gln Leu Glu
  65                  70                  75                  80
 Leu Gly Arg Phe Leu Arg Ser Arg Tyr Glu Ala Phe Leu Ser Pro Glu
                  85                  90                  95    
 Tyr Arg Arg Glu Glu Val Tyr Ile Arg Ser Thr Asp Phe Asp Arg Thr
             100                 105                 110        
 Leu Glu Ser Ala Gln Ala Asn Leu Ala Gly Leu Phe Pro Glu Ala Ala
         115                 120                 125            
 Pro Gly Ser Pro Glu Ala Arg Trp Arg Pro Ile Pro Val His Thr Val
     130                 135                 140                
 Pro Val Ala Glu Asp Lys Leu Leu Arg Phe Pro Met Arg Ser Cys Pro
 145                 150                 155                 160
 Arg Tyr His Glu Leu Leu Arg Glu Ala Thr Glu Ala Ala Glu Tyr Gln
                 165                 170                 175    
 Glu Ala Leu Glu Gly Trp Thr Gly Phe Leu Ser Arg Leu Glu Asn Phe
             180                 185                 190        
 Thr Gly Leu Ser Leu Val Gly Glu Pro Leu Arg Arg Ala Trp Lys Val
         195                 200                 205            
 Leu Asp Thr Leu Met Cys Gln Gln Ala His Gly Leu Pro Leu Pro Ala
     210                 215                 220                
 Trp Ala Ser Pro Asp Val Leu Arg Thr Leu Ala Gln Ile Ser Ala Leu
 225                 230                 235                 240
 Asp Ile Gly Ala His Val Gly Pro Pro Arg Ala Ala Glu Lys Ala Gln
                 245                 250                 255    
 Leu Thr Gly Gly Ile Leu Leu Asn Ala Ile Leu Ala Asn Phe Ser Arg
             260                 265                 270        
 Val Gln Arg Leu Gly Leu Pro Leu Lys Met Val Met Tyr Ser Ala His
         275                 280                 285            
 Asp Ser Thr Leu Leu Ala Leu Gln Gly Ala Leu Gly Leu Tyr Asp Gly
     290                 295                 300                
 His Thr Pro Pro Tyr Ala Ala Cys Leu Gly Phe Glu Phe Arg Lys His
 305                 310                 315                 320
 Leu Gly Asn Pro Ala Lys Asp Gly Gly Asn Val Thr Val Ser Leu Phe
                 325                 330                 335    
 Tyr Arg Asn Asp Ser Ala His Leu Pro Leu Pro Leu Ser Leu Pro Gly
             340                 345                 350        
 Cys Pro Ala Pro Cys Pro Leu Gly Arg Phe Tyr Gln Leu Thr Ala Pro
         355                 360                 365            
 Ala Arg Pro Pro Ala His Gly Val Ser Cys His Gly Pro Tyr Glu Ala
     370                 375                 380                
 Ala Ile Pro Pro Ala Pro Val Val Pro Leu Leu Ala Gly Ala Val Ala
 385                 390                 395                 400
 Val Leu Val Ala Leu Ser Leu Gly Leu Gly Leu Leu Ala Trp Arg Pro
                 405                 410                 415    
 Gly Cys Leu Arg Ala Leu Gly Gly Pro Val
             420                 425    



      <210> 959
      <211> 332
      <212> PRT
      <213> Homo sapiens


      <400> 959
 Met Leu Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu
   1               5                  10                  15    
 Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu
              20                  25                  30        
 Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu
          35                  40                  45            
 Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu
      50                  55                  60                
 Val Asp Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala
  65                  70                  75                  80
 Phe Thr Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn
                  85                  90                  95    
 Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys
             100                 105                 110        
 Glu Leu Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe
         115                 120                 125            
 Lys Gly Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu
     130                 135                 140                
 Asp Phe His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys
 145                 150                 155                 160
 Arg Leu Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp
                 165                 170                 175    
 Val Leu Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu
             180                 185                 190        
 Pro Asp Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp
         195                 200                 205            
 Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu
     210                 215                 220                
 His Leu Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val
 225                 230                 235                 240
 Leu Gly Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu
                 245                 250                 255    
 Ser Gly Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His
             260                 265                 270        
 Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala
         275                 280                 285            
 Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe
     290                 295                 300                
 Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro
 305                 310                 315                 320
 Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln Lys
                 325                 330        



      <210> 960
      <211> 400
      <212> PRT
      <213> Homo sapiens


      <400> 960
 Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
   1               5                  10                  15    
 Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
              20                  25                  30        
 Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
          35                  40                  45            
 Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
      50                  55                  60                
 Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
  65                  70                  75                  80
 Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                  85                  90                  95    
 His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro
             100                 105                 110        
 Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn
         115                 120                 125            
 Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu
     130                 135                 140                
 Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys
 145                 150                 155                 160
 Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu
                 165                 170                 175    
 Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Asn
             180                 185                 190        
 Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val Lys Asp
         195                 200                 205            
 Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val Lys Val
     210                 215                 220                
 Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys Lys Lys
 225                 230                 235                 240
 Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala
                 245                 250                 255    
 Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu Asn Glu
             260                 265                 270        
 Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg
         275                 280                 285            
 Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp
     290                 295                 300                
 Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe Ser Asn
 305                 310                 315                 320
 Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys Leu Ser
                 325                 330                 335    
 Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr Glu
             340                 345                 350        
 Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro Pro
         355                 360                 365            
 Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn
     370                 375                 380                
 Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln Lys
 385                 390                 395                 400





      <210> 961
      <211> 400
      <212> PRT
      <213> Homo sapiens


      <400> 961
 Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
   1               5                  10                  15    
 Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
              20                  25                  30        
 Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
          35                  40                  45            
 Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
      50                  55                  60                
 Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
  65                  70                  75                  80
 Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                  85                  90                  95    
 His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro
             100                 105                 110        
 Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn
         115                 120                 125            
 Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu
     130                 135                 140                
 Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Thr Lys
 145                 150                 155                 160
 Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys Ile Val
                 165                 170                 175    
 Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu Val Asn
             180                 185                 190        
 Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val Lys Asp
         195                 200                 205            
 Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val Lys Val
     210                 215                 220                
 Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys Lys Lys
 225                 230                 235                 240
 Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala
                 245                 250                 255    
 Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu Asn Glu
             260                 265                 270        
 Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg
         275                 280                 285            
 Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp
     290                 295                 300                
 Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe Ser Asn
 305                 310                 315                 320
 Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys Leu Ser
                 325                 330                 335    
 Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr Glu
             340                 345                 350        
 Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro Pro
         355                 360                 365            
 Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn
     370                 375                 380                
 Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln Lys
 385                 390                 395                 400





      <210> 962
      <211> 400
      <212> PRT
      <213> Homo sapiens


      <400> 962
 Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
   1               5                  10                  15    
 Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
              20                  25                  30        
 Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
          35                  40                  45            
 Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
      50                  55                  60                
 Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
  65                  70                  75                  80
 Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                  85                  90                  95    
 His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro
             100                 105                 110        
 Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn
         115                 120                 125            
 Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu
     130                 135                 140                
 Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys
 145                 150                 155                 160
 Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu
                 165                 170                 175    
 Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys
             180                 185                 190        
 Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu
         195                 200                 205            
 Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val
     210                 215                 220                
 Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val
 225                 230                 235                 240
 Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys
                 245                 250                 255    
 Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala
             260                 265                 270        
 Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu
         275                 280                 285            
 Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Gly Thr Tyr Asp
     290                 295                 300                
 Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe Ser Asn
 305                 310                 315                 320
 Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys Leu Ser
                 325                 330                 335    
 Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr Glu
             340                 345                 350        
 Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro Pro
         355                 360                 365            
 Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn
     370                 375                 380                
 Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln Lys
 385                 390                 395                 400





      <210> 963
      <211> 338
      <212> PRT
      <213> Homo sapiens


      <400> 963
 Met Arg Gly Glu Glu Cys Pro Leu Asp Leu Asp Leu Asp Leu Asp Leu
   1               5                  10                  15    
 Asp Leu Asp Leu Asp Leu Ala Gln Ala Thr Gly Trp Asp Ser Ala Glu
              20                  25                  30        
 Ala Leu Thr Arg Ala Thr Gln Leu Ser Ala Ala Arg Arg Asn Leu Leu
          35                  40                  45            
 Cys Tyr Gly Phe Gln Asp Leu Lys Glu Arg Arg Ser Leu Thr His Arg
      50                  55                  60                
 Ile Ser Thr Ser Glu Thr Gly Thr Asn Ser Lys Gln His Arg Asp Leu
  65                  70                  75                  80
 Leu Thr Arg Ala Glu Ser Ala Leu Thr Gln Ala Tyr Ser Trp Leu Leu
                  85                  90                  95    
 Arg Ala Gln Ile Ser Ile Glu Ser Gly Glu Gly Gly Arg Gly Ala Ala
             100                 105                 110        
 Ala Asn Pro Ser Gly Glu Lys Leu Asp Asp Cys Cys Arg Glu Asp Ala
         115                 120                 125            
 Gly Tyr Met Val Glu Ala Gln Arg Leu Ser Lys Arg Asn Met Ala Gly
     130                 135                 140                
 Ser Ala Ser Ser Ser Leu Ser Arg Glu Gly Asp Ser Ser Glu Pro Lys
 145                 150                 155                 160
 Pro Trp Pro Gly Asn Val Gly Val Glu Gly Ser His Ala Glu Pro Gly
                 165                 170                 175    
 Ile Leu Val Ser Ser Met His Gly Arg Thr Ser Ala Leu Arg Thr Val
             180                 185                 190        
 Leu Cys Ala Glu Arg Val Leu Lys Thr Cys Asp Lys Gly Ala Asp Gln
         195                 200                 205            
 Gly His Lys Thr Glu Asp Trp Val Gln Gly Ser Gln Arg Cys Cys Phe
     210                 215                 220                
 Arg Ser Pro Glu Gly Glu Glu Ala Ala Val Arg Ser Gly Thr Pro Pro
 225                 230                 235                 240
 Leu Asn Leu Ser Gln Arg Lys Ala Gly Arg Cys Asn Gln Pro Ala Trp
                 245                 250                 255    
 Ser Ser Met Pro Leu Thr Glu Glu Gln Glu Gly Leu Ala Gly Pro Lys
             260                 265                 270        
 Trp Thr Gln Ala Asp Ile Lys Leu Leu Pro Phe Ile Ser Lys Asn Arg
         275                 280                 285            
 Lys Glu Val Asp Leu Thr Leu Gly Gln Met Leu Trp Ile Glu Ile Met
     290                 295                 300                
 Arg Ser Phe Asp Thr Ser Ser Asn Leu Glu Val Thr Asp Thr Asp Phe
 305                 310                 315                 320
 Phe Leu Asp Thr Met Asp Lys Ala Gln Ala Gly Pro Glu Phe Gly Gln
                 325                 330                 335    
 Arg Thr
        



      <210> 964
      <211> 814
      <212> PRT
      <213> Homo sapiens


      <400> 964
 Met Ser Leu Val Ala Leu Leu Lys Asp Ser Ala Asn Ile Leu Pro Leu
   1               5                  10                  15    
 Trp Lys Asn Gln Val Ala Leu Glu Glu Ala Lys Ile Lys Phe Gln Thr
              20                  25                  30        
 Trp Ala Pro Gln Lys Trp Asn Leu Arg Leu Gly Leu Val Pro Gly Pro
          35                  40                  45            
 Ser Cys Ile Arg Leu Glu Ile Leu Met Leu Leu Val Ile Phe Val Pro
      50                  55                  60                
 Ser Met Tyr Cys His Leu Gly Ser Ile Tyr Tyr Ser Phe Tyr Glu Ile
  65                  70                  75                  80
 Ile Ile Pro Lys Arg Leu Thr Val Gln Gly Gly Asp Ser Pro Val Glu
                  85                  90                  95    
 Gly Leu Ser Tyr Leu Leu Leu Met Gln Gly Gln Lys His Leu Val His
             100                 105                 110        
 Leu Lys Val Lys Arg Asn His Phe Val Asn Asn Phe Pro Val Tyr Ser
         115                 120                 125            
 Tyr His Asn Gly Leu Leu Gly Gln Glu Ser Pro Phe Ile Ser His Asp
     130                 135                 140                
 Cys His Tyr Glu Gly Tyr Ile Glu Gly Val Ser Gly Ser Phe Val Ser
 145                 150                 155                 160
 Val Asn Ile Cys Ala Gly Leu Arg Gly Ile Ile Leu Leu Ile Lys Glu
                 165                 170                 175    
 Glu Lys Ser Tyr Ser Ile Glu Pro Met Asp Ser Ser Arg Arg Phe Glu
             180                 185                 190        
 His Val Leu Tyr Thr Met Ala His Gln Ala Arg Val Ser Cys Gly Val
         195                 200                 205            
 Thr Ser Trp Gln Gln Gly Ser Arg Lys Pro His Asp Leu Gln Ala Leu
     210                 215                 220                
 Ser Tyr Leu Trp Ser His Lys Lys Tyr Val Glu Met Phe Val Val Val
 225                 230                 235                 240
 Asn Asn Gln Arg Phe Gln Met Trp Gly Ser Asn Val Asn Glu Thr Val
                 245                 250                 255    
 Gln Thr Val Val Asp Val Ile Ala Leu Ala Asn Ser Phe Thr Arg Gly
             260                 265                 270        
 Ile Asn Thr Glu Val Val Leu Ala Gly Met Glu Ile Trp Thr Glu Gly
         275                 280                 285            
 Asp Leu Ile Asp Val Thr Val Asp Leu Gln Ile Thr Leu Arg Asn Phe
     290                 295                 300                
 Asn His Trp Arg Gln Glu Met Leu Phe His Arg Ala Lys His Asp Val
 305                 310                 315                 320
 Ala His Met Ile Val Gly His His Pro Gly Gln Asn Met Gly Gln Ala
                 325                 330                 335    
 Phe Leu Ser Gly Ala Cys Ser Ser Gly Phe Ala Ala Ala Val Glu Ser
             340                 345                 350        
 Phe His His Glu Asp Val Leu Leu Phe Ala Ala Leu Met Ala His Glu
         355                 360                 365            
 Leu Gly His Asn Leu Gly Ile Gln His Asp His Ser Ala Cys Phe Cys
     370                 375                 380                
 Lys Asp Lys His Phe Cys Leu Met His Glu Asn Ile Thr Lys Glu Ser
 385                 390                 395                 400
 Gly Phe Ser Ser Cys Ser Ser Asp Tyr Phe Tyr Gln Phe Leu Arg Glu
                 405                 410                 415    
 His Lys Gly Ala Cys Leu Phe Asn Lys Pro Arg Pro Arg Gly Arg Lys
             420                 425                 430        
 Arg Arg Asp Ser Ala Cys Gly Asn Gly Val Val Glu Asp Thr Glu Gln
         435                 440                 445            
 Cys Asp Cys Gly Ser Leu Cys Gln His His Ala Cys Cys Asp Glu Asn
     450                 455                 460                
 Cys Ile Leu Lys Ala Lys Ala Glu Cys Ser Asp Gly Pro Cys Cys His
 465                 470                 475                 480
 Lys Cys Lys Phe His Arg Lys Gly Tyr Pro Cys Cys Pro Ser Ser Arg
                 485                 490                 495    
 Ser Cys Asp Leu Pro Glu Phe Cys Asn Gly Thr Ser Ala Leu Cys Pro
             500                 505                 510        
 Asn Asn Arg His Lys Gln Asp Gly Ser Lys Cys His Thr Ile Tyr Glu
         515                 520                 525            
 Cys Leu Lys Val His Cys Met Asp Pro Asn Asn Gln Cys Leu Gln Leu
     530                 535                 540                
 Tyr Gly Tyr Gly Ala Lys Ser Ala Ser Gln Glu Cys Tyr Asn Ser Met
 545                 550                 555                 560
 Asn Ser Lys Gly Asp Gln Phe Gly Asn Cys Gly Ile Ser Thr Ser Pro
                 565                 570                 575    
 Gly Ser Gln Tyr Val Arg Cys Ser Asp Gly Asn Ile Phe Cys Gly Lys
             580                 585                 590        
 Leu Ile Cys Ser Gly Ile Thr Gly Leu Pro Lys Ile Asn Leu Gln His
         595                 600                 605            
 Thr Met Ile Gln Val Pro Gln Gly Asp Gly Ser Cys Trp Ser Met Asp
     610                 615                 620                
 Ala Tyr Met Ser Thr Asp Ile Pro Asp Glu Gly Asp Val His Asn Gly
 625                 630                 635                 640
 Thr Tyr Cys Ala Pro Asn Lys Val Cys Leu Asn Ser Ala Cys Thr Asp
                 645                 650                 655    
 Lys Thr Pro Val Ile Ser Ala Cys Asn Pro Glu Lys Thr Cys Asn Gly
             660                 665                 670        
 Lys Gly Val Cys Asn Asp Leu Gly His Cys His Cys Asn Glu Gly His
         675                 680                 685            
 Ala Pro Pro Asp Cys Val Thr Ala Gly Ser Gly Gly Ser Val Asp Ser
     690                 695                 700                
 Gly Pro Pro Gly Lys Leu Gly Gly Thr Pro Ser Gly Glu Gly Glu Asn
 705                 710                 715                 720
 His Asn Met Thr His Ser Arg Arg Glu Glu His Ala Val Asp Met Met
                 725                 730                 735    
 Ile Leu Ser Phe Ile Ile Leu Phe Ile Ile Leu Leu Leu Ser Thr Ile
             740                 745                 750        
 Ile Cys Ile Cys Leu Leu Lys Lys Ser Pro Glu Ala Ala Pro Ala Glu
         755                 760                 765            
 Ala Pro Pro Ala Val Ala Pro Pro Pro Ala Pro Glu Ile Lys Pro Glu
     770                 775                 780                
 Ala Ala Glu Val Ala Thr Glu Glu Lys Glu Glu Lys Glu Glu Glu Lys
 785                 790                 795                 800
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ser Asp Ser
                 805                 810                



      <210> 965
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 965
 Met Arg Leu Ser Val Cys Leu Leu Leu Leu Thr Leu Ala Leu Cys Cys
   1               5                  10                  15    
 Tyr Arg Ala Asn Ala Val Val Cys Gln Ala Leu Gly Ser Glu Ile Thr
              20                  25                  30        
 Gly Phe Leu Leu Ala Gly Lys Pro Val Phe Lys Phe Gln Leu Ala Lys
          35                  40                  45            
 Phe Lys Ala Pro Leu Glu Ala Val Ala Ala Lys Met Glu Val Lys Lys
      50                  55                  60                
 Cys Val Asp Thr Met Ala Tyr Glu Lys Arg Val Leu Ile Thr Lys Thr
  65                  70                  75                  80
 Leu Gly Lys Ile Ala Glu Lys Cys Asp Arg
                  85                  90



      <210> 966
      <211> 529
      <212> PRT
      <213> Homo sapiens


      <400> 966
 Met Phe Thr Val Leu Thr Arg Gln Pro Cys Glu Gln Ala Gly Leu Lys
   1               5                  10                  15    
 Ala Leu Tyr Arg Thr Pro Thr Ile Ile Ala Leu Val Val Leu Leu Val
              20                  25                  30        
 Ser Ile Val Val Leu Val Ser Ile Thr Val Ile Gln Ile His Lys Gln
          35                  40                  45            
 Glu Val Leu Pro Pro Gly Leu Lys Tyr Gly Ile Val Leu Asp Ala Gly
      50                  55                  60                
 Ser Ser Arg Thr Thr Val Tyr Val Tyr Gln Trp Pro Ala Glu Lys Glu
  65                  70                  75                  80
 Asn Asn Thr Gly Val Val Ser Gln Thr Phe Lys Cys Ser Val Lys Gly
                  85                  90                  95    
 Ser Gly Ile Ser Ser Tyr Gly Asn Asn Pro Gln Asp Val Pro Arg Ala
             100                 105                 110        
 Phe Glu Glu Cys Met Gln Lys Val Lys Gly Gln Val Pro Ser His Leu
         115                 120                 125            
 His Gly Ser Thr Pro Ile His Leu Gly Ala Thr Ala Gly Met Arg Leu
     130                 135                 140                
 Leu Arg Leu Gln Asn Glu Thr Ala Ala Asn Glu Val Leu Glu Ser Ile
 145                 150                 155                 160
 Gln Ser Tyr Phe Lys Ser Gln Pro Phe Asp Phe Arg Gly Ala Gln Ile
                 165                 170                 175    
 Ile Ser Gly Gln Glu Glu Gly Val Tyr Gly Trp Ile Thr Ala Asn Tyr
             180                 185                 190        
 Leu Met Gly Asn Phe Leu Glu Lys Asn Leu Trp His Met Trp Val His
         195                 200                 205            
 Pro His Gly Val Glu Thr Thr Gly Ala Leu Asp Leu Gly Gly Ala Ser
     210                 215                 220                
 Thr Gln Ile Ser Phe Val Ala Gly Glu Lys Met Asp Leu Asn Thr Ser
 225                 230                 235                 240
 Asp Ile Met Gln Val Ser Leu Tyr Gly Tyr Val Tyr Thr Leu Tyr Thr
                 245                 250                 255    
 His Ser Phe Gln Cys Tyr Gly Arg Asn Glu Ala Glu Lys Lys Phe Leu
             260                 265                 270        
 Ala Met Leu Leu Gln Asn Ser Pro Thr Lys Asn His Leu Thr Asn Pro
         275                 280                 285            
 Cys Tyr Pro Arg Asp Tyr Ser Ile Ser Phe Thr Met Gly His Val Phe
     290                 295                 300                
 Asp Ser Leu Cys Thr Val Asp Gln Arg Pro Glu Ser Tyr Asn Pro Asn
 305                 310                 315                 320
 Asp Val Ile Thr Phe Glu Gly Thr Gly Asp Pro Ser Leu Cys Lys Glu
                 325                 330                 335    
 Lys Val Ala Ser Ile Phe Asp Phe Lys Ala Cys His Asp Gln Glu Thr
             340                 345                 350        
 Cys Ser Phe Asp Gly Val Tyr Gln Pro Lys Ile Lys Gly Pro Phe Val
         355                 360                 365            
 Ala Phe Ala Gly Phe Tyr Tyr Thr Ala Ser Ala Leu Asn Leu Ser Gly
     370                 375                 380                
 Ser Phe Ser Leu Asp Thr Phe Asn Ser Ser Thr Trp Asn Phe Cys Ser
 385                 390                 395                 400
 Gln Asn Trp Ser Gln Leu Pro Leu Leu Leu Pro Lys Phe Asp Glu Val
                 405                 410                 415    
 Tyr Ala Arg Ser Tyr Cys Phe Ser Ala Asn Tyr Ile Tyr His Leu Phe
             420                 425                 430        
 Val Asn Gly Tyr Lys Phe Thr Glu Glu Thr Trp Pro Gln Ile His Phe
         435                 440                 445            
 Glu Lys Glu Val Gly Asn Ser Ser Ile Ala Trp Ser Leu Gly Tyr Met
     450                 455                 460                
 Leu Ser Leu Thr Asn Gln Ile Pro Ala Glu Ser Pro Leu Ile Arg Leu
 465                 470                 475                 480
 Pro Ile Glu Pro Pro Val Phe Val Gly Thr Leu Ala Phe Phe Thr Val
                 485                 490                 495    
 Ala Ala Leu Leu Cys Leu Ala Phe Leu Ala Tyr Leu Cys Ser Ala Thr
             500                 505                 510        
 Arg Arg Lys Arg His Ser Glu His Ala Phe Asp His Ala Val Asp Ser
         515                 520                 525            
 Asp
    



      <210> 967
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 967
 Met Leu Gly Ala Lys Pro His Trp Leu Pro Gly Pro Leu His Ser Pro
   1               5                  10                  15    
 Gly Leu Pro Leu Val Leu Val Leu Leu Ala Leu Gly Ala Gly Trp Ala
              20                  25                  30        
 Gln Glu Gly Ser Glu Pro Val Leu Leu Glu Gly Glu Cys Leu Val Val
          35                  40                  45            
 Cys Glu Pro Gly Arg Ala Ala Ala Gly Gly Pro Gly Gly Ala Ala Leu
      50                  55                  60                
 Gly Glu Ala Pro Pro Gly Arg Val Ala Phe Ala Ala Val Arg Ser His
  65                  70                  75                  80
 His His Glu Pro Ala Gly Glu Thr Gly Asn Gly Thr Ser Gly Ala Ile
                  85                  90                  95    
 Tyr Phe Asp Gln Val Met Val Asn Glu Gly Gly Gly Phe Asp Arg Ala
             100                 105                 110        
 Ser Gly Ser Phe Val Ala Pro Val Arg Gly Val Tyr Ser Phe Arg Phe
         115                 120                 125            
 His Val Val Lys Val Tyr Asn Arg Gln Thr Val Gln Val Ser Leu Val
     130                 135                 140                
 Leu Asn Thr Trp Pro Val Ile Ser Ala Phe Ala Asn Asp Pro Asp Val
 145                 150                 155                 160
 Thr Arg Glu Ala Ala Thr Ser Ser Val Leu Leu Pro Leu Asp Pro Gly
                 165                 170                 175    
 Asp Arg Val Ser Leu Arg Leu Arg Arg Gly Asn Leu Leu Gly Gly Trp
             180                 185                 190        
 Lys Tyr Ser Ser Phe Ser Gly Phe Leu Ile Phe Pro Leu
         195                 200                 205



      <210> 968
      <211> 238
      <212> PRT
      <213> Homo sapiens


      <400> 968
 Met Gly Cys Asp Gly Arg Val Ser Gly Leu Leu Arg Arg Asn Leu Gln
   1               5                  10                  15    
 Pro Thr Leu Thr Tyr Trp Ser Val Phe Phe Ser Phe Gly Leu Cys Ile
              20                  25                  30        
 Ala Phe Leu Gly Pro Thr Leu Leu Asp Leu Arg Cys Gln Thr His Ser
          35                  40                  45            
 Ser Leu Pro Gln Ile Ser Trp Val Phe Phe Ser Gln Gln Leu Cys Leu
      50                  55                  60                
 Leu Leu Gly Ser Ala Leu Gly Gly Val Phe Lys Arg Thr Leu Ala Gln
  65                  70                  75                  80
 Ser Leu Trp Ala Leu Phe Thr Ser Ser Leu Ala Ile Ser Leu Val Phe
                  85                  90                  95    
 Ala Val Ile Pro Phe Cys Arg Asp Val Lys Val Leu Ala Ser Val Met
             100                 105                 110        
 Ala Leu Ala Gly Leu Ala Met Gly Cys Ile Asp Thr Val Ala Asn Met
         115                 120                 125            
 Gln Leu Val Arg Met Tyr Gln Lys Asp Ser Ala Val Phe Leu Gln Val
     130                 135                 140                
 Leu His Phe Phe Val Gly Phe Gly Ala Leu Leu Ser Pro Leu Ile Ala
 145                 150                 155                 160
 Asp Pro Phe Leu Ser Glu Ala Asn Cys Leu Pro Ala Asn Ser Thr Ala
                 165                 170                 175    
 Asn Thr Thr Ser Arg Gly His Leu Phe His Val Ser Arg Val Leu Gly
             180                 185                 190        
 Gln His His Val Asp Ala Lys Pro Trp Ser Asn Gln Thr Phe Pro Gly
         195                 200                 205            
 Leu Thr Pro Lys Asp Gly Ala Gly Thr Arg Ser Val Leu Cys Leu Leu
     210                 215                 220                
 Asp His Gly His His Gln Ser Ser Ser Ala His Trp Leu Cys
 225                 230                 235            



      <210> 969
      <211> 549
      <212> PRT
      <213> Homo sapiens


      <400> 969
 Met Met Ile Val Pro Val Asn Ser His Cys Thr Pro Ala Trp Ala Thr
   1               5                  10                  15    
 Lys Arg Ala Ser Ile Ser Arg Leu Ser Gln Lys Glu Asn Leu Lys Arg
              20                  25                  30        
 Pro Val Thr Gly Asn Lys Ile Ala Pro Ile Met Pro Leu His Ser Ser
          35                  40                  45            
 Leu Gly Tyr Arg Ala Arg Pro Tyr Trp Ser Val Phe Phe Ser Phe Gly
      50                  55                  60                
 Leu Cys Ile Ala Phe Leu Gly Pro Thr Leu Leu Asp Leu Arg Cys Gln
  65                  70                  75                  80
 Thr His Ser Ser Leu Pro Gln Ile Ser Trp Val Phe Phe Ser Gln Gln
                  85                  90                  95    
 Leu Cys Leu Leu Leu Gly Ser Ala Leu Gly Gly Val Phe Lys Arg Thr
             100                 105                 110        
 Leu Ala Gln Ser Leu Trp Ala Leu Phe Thr Ser Ser Leu Ala Ile Ser
         115                 120                 125            
 Leu Val Phe Ala Val Ile Pro Phe Cys Arg Asp Val Lys Val Leu Ala
     130                 135                 140                
 Ser Val Met Ala Leu Ala Gly Leu Ala Met Gly Cys Ile Asp Thr Val
 145                 150                 155                 160
 Ala Asn Met Gln Leu Val Arg Met Tyr Gln Lys Asp Ser Ala Val Phe
                 165                 170                 175    
 Leu Gln Val Leu His Phe Phe Val Gly Phe Gly Ala Leu Leu Ser Pro
             180                 185                 190        
 Leu Ile Ala Asp Pro Phe Leu Ser Glu Ala Asn Cys Leu Pro Ala Asn
         195                 200                 205            
 Ser Thr Ala Asn Thr Thr Ser Arg Gly His Leu Phe His Val Ser Arg
     210                 215                 220                
 Val Leu Gly Gln His His Val Asp Ala Lys Pro Trp Ser Asn Gln Thr
 225                 230                 235                 240
 Phe Pro Gly Leu Thr Pro Lys Asp Gly Ala Gly Thr Arg Val Ser Tyr
                 245                 250                 255    
 Ala Phe Trp Ile Met Ala Ile Ile Asn Leu Pro Val Pro Thr Ala Val
             260                 265                 270        
 Leu Met Leu Leu Ser Lys Glu Arg Leu Leu Thr Cys Cys Pro Gln Arg
         275                 280                 285            
 Arg Pro Leu Leu Leu Ser Ala Asp Glu Leu Ala Leu Glu Thr Gln Pro
     290                 295                 300                
 Pro Glu Lys Glu Asp Ala Ser Ser Leu Pro Pro Lys Phe Gln Ser His
 305                 310                 315                 320
 Leu Gly His Glu Asp Leu Phe Ser Cys Cys Gln Arg Lys Asn Leu Arg
                 325                 330                 335    
 Gly Ala Pro Tyr Ser Phe Phe Ala Ile His Ile Thr Gly Ala Leu Val
             340                 345                 350        
 Leu Phe Met Thr Asp Gly Leu Thr Gly Ala Tyr Ser Ala Phe Val Tyr
         355                 360                 365            
 Ser Tyr Ala Val Glu Lys Pro Leu Ser Val Gly His Lys Val Ala Gly
     370                 375                 380                
 Tyr Leu Pro Ser Leu Phe Trp Gly Phe Ile Thr Leu Gly Arg Leu Leu
 385                 390                 395                 400
 Ser Ile Pro Ile Ser Ser Arg Met Lys Pro Ala Thr Met Val Phe Ile
                 405                 410                 415    
 Asn Val Val Gly Val Val Val Thr Phe Leu Val Leu Leu Ile Phe Ser
             420                 425                 430        
 Tyr Asn Val Val Phe Leu Phe Val Gly Thr Ala Ser Leu Gly Leu Phe
         435                 440                 445            
 Leu Ser Ser Thr Phe Pro Ser Met Leu Ala Tyr Thr Glu Asp Ser Leu
     450                 455                 460                
 Gln Tyr Lys Gly Cys Ala Thr Thr Val Leu Val Thr Gly Ala Gly Val
 465                 470                 475                 480
 Gly Glu Met Val Leu Gln Met Leu Val Gly Ser Ile Phe Gln Ala Gln
                 485                 490                 495    
 Gly Ser Tyr Ser Phe Leu Val Cys Gly Val Ile Phe Gly Cys Leu Ala
             500                 505                 510        
 Phe Thr Phe Tyr Ile Leu Leu Leu Phe Phe His Arg Met His Pro Gly
         515                 520                 525            
 Leu Pro Ser Val Pro Thr Gln Asp Arg Ser Ile Gly Met Glu Asn Ser
     530                 535                 540                
 Glu Cys Tyr Gln Arg
 545                



      <210> 970
      <211> 580
      <212> PRT
      <213> Homo sapiens


      <400> 970
 Met Thr Trp Arg Ala Ala Ala Ser Thr Cys Ala Ala Leu Leu Ile Leu
   1               5                  10                  15    
 Leu Trp Ala Leu Thr Thr Glu Gly Asp Leu Lys Val Glu Met Met Ala
              20                  25                  30        
 Gly Gly Thr Gln Ile Thr Pro Leu Asn Asp Asn Val Thr Ile Phe Cys
          35                  40                  45            
 Asn Ile Phe Tyr Ser Gln Pro Leu Asn Ile Thr Ser Met Gly Ile Thr
      50                  55                  60                
 Trp Phe Trp Lys Ser Leu Thr Phe Asp Lys Glu Val Lys Val Phe Glu
  65                  70                  75                  80
 Phe Phe Gly Asp His Gln Glu Ala Phe Arg Pro Gly Ala Ile Val Ser
                  85                  90                  95    
 Pro Trp Arg Leu Lys Ser Gly Asp Ala Ser Leu Arg Leu Pro Gly Ile
             100                 105                 110        
 Gln Leu Glu Glu Ala Gly Glu Tyr Arg Cys Glu Val Val Val Thr Pro
         115                 120                 125            
 Leu Lys Ala Gln Gly Thr Val Gln Leu Glu Val Val Ala Ser Pro Ala
     130                 135                 140                
 Ser Arg Leu Leu Leu Asp Gln Val Gly Met Lys Glu Asn Glu Asp Lys
 145                 150                 155                 160
 Tyr Met Cys Glu Ser Ser Gly Phe Tyr Pro Glu Ala Ile Asn Ile Thr
                 165                 170                 175    
 Trp Glu Lys Gln Thr Gln Lys Phe Pro His Pro Ile Glu Ile Ser Glu
             180                 185                 190        
 Asp Val Ile Thr Gly Pro Thr Ile Lys Asn Met Asp Gly Thr Phe Asn
         195                 200                 205            
 Val Thr Ser Cys Leu Lys Leu Asn Ser Ser Gln Glu Asp Pro Gly Thr
     210                 215                 220                
 Val Tyr Gln Cys Val Val Arg His Ala Ser Leu His Thr Pro Leu Arg
 225                 230                 235                 240
 Ser Asn Phe Thr Leu Thr Ala Ala Arg His Ser Leu Ser Glu Thr Glu
                 245                 250                 255    
 Lys Thr Asp Asn Phe Ser Ile His Trp Trp Pro Ile Ser Phe Ile Gly
             260                 265                 270        
 Val Gly Leu Val Leu Leu Ile Val Leu Ile Pro Trp Lys Lys Val Arg
         275                 280                 285            
 Gly Ser Lys Ala Lys Phe Ser Pro Val Ser Trp Ala Ser Lys Lys Leu
     290                 295                 300                
 Leu Glu Gln Leu Leu Pro Thr Leu Gln Ala Ser Arg Asp Arg Pro Ala
 305                 310                 315                 320
 Gly Lys Asp Phe Val Ser Pro Ser Ser Pro Ser Gly Val Gly Asn Val
                 325                 330                 335    
 Gly Cys Val Pro Ile Gln Phe Pro Ile Thr Glu Asp Leu Ala Val Thr
             340                 345                 350        
 Tyr His Leu Thr Ser Val Trp Trp Phe Val Thr Leu Gly Val Leu Pro
         355                 360                 365            
 Gln Ser Asn Tyr Cys Thr Ile Ser Pro Met Val Leu Gly Asn Leu Arg
     370                 375                 380                
 Ser Leu Met Gly Gln Val Gly Leu Gly Asn Gln Gln Gly Arg Glu Leu
 385                 390                 395                 400
 Gly Pro Cys Ala Glu Lys Gln Val Ala Leu Gln Ala Ala Glu Lys Phe
                 405                 410                 415    
 Arg Asp Glu Gln His Val Phe Tyr Ser His Ser Ile Arg Lys Glu Gly
             420                 425                 430        
 Met Phe Ile Pro His Ile Asn Asn Ser Ile Glu Gly Gln Leu Ile Leu
         435                 440                 445            
 Lys Asp Lys Phe Ile Thr Gln Thr Ala Pro Asp Ile Arg Arg Lys Leu
     450                 455                 460                
 Glu Lys Gln Ala Met Gly Leu Asp Ser Thr Leu Gln Asn Leu Leu Lys
 465                 470                 475                 480
 Val Ala Thr Ser Val Phe Tyr Asn Arg Asp Gln Glu Glu Ala Gln Gly
                 485                 490                 495    
 Lys Glu Arg Lys His Lys Lys Lys Ala Glu Thr Leu Val Ala Thr Leu
             500                 505                 510        
 Tyr Lys Thr Gln Tyr Pro Gln Gly Thr Pro Ala Ser Cys Tyr Gln Cys
         515                 520                 525            
 Gly Lys Leu Gly His Phe Lys Arg Asp Cys Pro Gly Ser Lys Lys Lys
     530                 535                 540                
 Pro Pro Gln Pro Cys Pro Val Tyr Asn Gly Asp His Trp Lys Ala Asp
 545                 550                 555                 560
 Cys Pro Gly Lys His Arg Ser Leu Ser Pro Glu Pro Val Ser Gln Met
                 565                 570                 575    
 Val Gln Gln Asp
             580



      <210> 971
      <211> 489
      <212> PRT
      <213> Homo sapiens


      <400> 971
 Met Leu Ala Phe Leu Gly Ala Val Ile Cys Ile Ile Ala Ser Val Pro
   1               5                  10                  15    
 Leu Ala Ala Ser Pro Ala Arg Ala Leu Pro Gly Gly Ala Asp Asn Ala
              20                  25                  30        
 Ser Val Ala Ser Gly Ala Ala Ala Ser Pro Gly Pro Gln Arg Ser Leu
          35                  40                  45            
 Ser Ala Leu His Gly Ala Gly Gly Ser Ala Gly Pro Pro Ala Leu Pro
      50                  55                  60                
 Gly Ala Pro Ala Ala Ser Ala His Pro Leu Pro Pro Gly Pro Leu Phe
  65                  70                  75                  80
 Ser Arg Phe Leu Cys Thr Pro Leu Ala Ala Ala Cys Pro Ser Gly Ala
                  85                  90                  95    
 Gln Gln Gly Asp Ala Ala Gly Ala Ala Pro Gly Glu Arg Glu Glu Leu
             100                 105                 110        
 Leu Leu Leu Gln Ser Thr Ala Glu Gln Leu Arg Gln Thr Ala Leu Gln
         115                 120                 125            
 Gln Glu Ala Arg Ile Arg Ala Asp Gln Asp Thr Ile Arg Glu Leu Thr
     130                 135                 140                
 Gly Lys Leu Gly Arg Cys Glu Ser Gly Leu Pro Arg Gly Leu Gln Gly
 145                 150                 155                 160
 Ala Gly Pro Arg Arg Asp Thr Met Ala Asp Gly Pro Trp Asp Ser Pro
                 165                 170                 175    
 Ala Leu Ile Leu Glu Leu Glu Asp Ala Val Arg Ala Leu Arg Asp Arg
             180                 185                 190        
 Ile Asp Arg Leu Glu Gln Glu Leu Pro Ala Arg Val Asn Leu Ser Ala
         195                 200                 205            
 Ala Pro Ala Pro Val Ser Ala Val Pro Thr Gly Leu His Ser Lys Met
     210                 215                 220                
 Asp Gln Leu Glu Gly Gln Leu Leu Ala Gln Val Leu Ala Leu Glu Lys
 225                 230                 235                 240
 Glu Arg Val Ala Leu Ser His Ser Ser Arg Arg Gln Arg Gln Glu Val
                 245                 250                 255    
 Glu Lys Glu Leu Asp Val Leu Gln Gly Arg Val Ala Glu Leu Glu His
             260                 265                 270        
 Gly Ser Ser Ala Tyr Ser Pro Pro Asp Ala Phe Lys Ile Ser Ile Pro
         275                 280                 285            
 Ile Arg Asn Asn Tyr Met Tyr Ala Arg Val Arg Lys Ala Leu Pro Glu
     290                 295                 300                
 Leu Tyr Ala Phe Thr Ala Cys Met Trp Leu Arg Ser Arg Ser Ser Gly
 305                 310                 315                 320
 Thr Gly Gln Gly Thr Pro Phe Ser Tyr Ser Val Pro Gly Gln Ala Asn
                 325                 330                 335    
 Glu Ile Val Leu Leu Glu Ala Gly His Glu Pro Met Glu Leu Leu Ile
             340                 345                 350        
 Asn Asp Lys Val Ala Gln Leu Pro Leu Ser Leu Lys Asp Asn Gly Trp
         355                 360                 365            
 His His Ile Cys Ile Ala Trp Thr Thr Arg Asp Gly Leu Trp Ser Ala
     370                 375                 380                
 Tyr Gln Asp Gly Glu Leu Gln Gly Ser Gly Glu Asn Leu Ala Ala Trp
 385                 390                 395                 400
 His Pro Ile Lys Pro His Gly Ile Leu Ile Leu Gly Gln Glu Gln Asp
                 405                 410                 415    
 Thr Leu Gly Gly Arg Phe Asp Ala Thr Gln Ala Phe Val Gly Asp Ile
             420                 425                 430        
 Ala Gln Phe Asn Leu Trp Asp His Ala Leu Thr Pro Ala Gln Val Leu
         435                 440                 445            
 Gly Ile Ala Asn Cys Thr Ala Pro Leu Leu Gly Asn Val Leu Pro Trp
     450                 455                 460                
 Glu Asp Lys Leu Val Glu Ala Phe Gly Gly Ala Thr Lys Ala Ala Phe
 465                 470                 475                 480
 Asp Val Cys Lys Gly Arg Ala Lys Ala
                 485                



      <210> 972
      <211> 812
      <212> PRT
      <213> Homo sapiens


      <400> 972
 Met Pro Asn Val Ala Arg Gln Lys Leu Glu Thr Ile Arg Ser Val Gly
   1               5                  10                  15    
 Tyr Tyr Arg Asn Ile Tyr Gln Pro Pro Glu Gly Asn Ala Ser Val Ile
              20                  25                  30        
 Gln Asp Phe Thr Glu Asp Gly His Leu Leu His Thr Phe Tyr Leu Gly
          35                  40                  45            
 Thr Gly Arg Arg Val Ile Tyr Lys Tyr Gly Lys Leu Ser Lys Leu Ala
      50                  55                  60                
 Glu Thr Leu Tyr Asp Thr Thr Lys Val Ser Phe Thr Tyr Asp Glu Thr
  65                  70                  75                  80
 Ala Gly Met Leu Lys Thr Ile Asn Leu Gln Asn Glu Gly Phe Thr Cys
                  85                  90                  95    
 Thr Ile Arg Tyr Arg Gln Ile Gly Pro Leu Ile Asp Arg Gln Ile Phe
             100                 105                 110        
 Arg Phe Thr Glu Glu Gly Met Val Asn Ala Arg Phe Asp Tyr Asn Tyr
         115                 120                 125            
 Asp Asn Ser Phe Arg Val Thr Ser Met Gln Ala Val Ile Asn Glu Thr
     130                 135                 140                
 Pro Leu Pro Ile Asp Leu Tyr Arg Tyr Asp Asp Val Ser Gly Lys Thr
 145                 150                 155                 160
 Glu Gln Phe Gly Lys Phe Gly Val Ile Tyr Tyr Asp Ile Asn Gln Ile
                 165                 170                 175    
 Ile Thr Thr Pro Val Met Thr His Thr Lys His Phe Asp Ala Tyr Gly
             180                 185                 190        
 Arg Met Lys Glu Val Gln Tyr Glu Ile Phe Arg Ser Leu Met Tyr Trp
         195                 200                 205            
 Met Thr Val Gln Tyr Asp Asn Met Gly Arg Val Val Lys Lys Glu Leu
     210                 215                 220                
 Lys Val Gly Pro Tyr Ala Asn Thr Thr Arg Tyr Ser Tyr Glu Tyr Asp
 225                 230                 235                 240
 Ala Asp Gly Gln Leu Gln Thr Val Ser Ile Asn Asp Lys Pro Leu Trp
                 245                 250                 255    
 Arg Tyr Ser Tyr Asp Leu Asn Gly Asn Leu His Leu Leu Ser Pro Gly
             260                 265                 270        
 Asn Ser Ala Arg Leu Thr Pro Leu Arg Tyr Asp Ile Arg Asp Arg Ile
         275                 280                 285            
 Thr Arg Leu Gly Asp Val Gln Tyr Lys Met Asp Glu Asp Gly Phe Leu
     290                 295                 300                
 Arg Gln Arg Gly Gly Asp Ile Phe Glu Tyr Asn Ser Ala Gly Leu Leu
 305                 310                 315                 320
 Ile Lys Ala Tyr Asn Arg Ala Gly Ser Trp Ser Val Arg Tyr Arg Tyr
                 325                 330                 335    
 Asp Gly Leu Gly Arg Arg Val Ser Ser Lys Ser Ser His Ser His His
             340                 345                 350        
 Leu Gln Phe Phe Tyr Ala Asp Leu Thr Asn Pro Thr Lys Val Thr His
         355                 360                 365            
 Leu Tyr Asn His Ser Ser Ser Glu Ile Thr Ser Leu Tyr Tyr Asp Leu
     370                 375                 380                
 Gln Gly His Leu Phe Ala Met Glu Leu Ser Ser Gly Asp Glu Phe Tyr
 385                 390                 395                 400
 Ile Ala Cys Asp Asn Ile Gly Thr Pro Leu Ala Val Phe Ser Gly Thr
                 405                 410                 415    
 Gly Leu Met Ile Lys Gln Ile Leu Tyr Thr Ala Tyr Gly Glu Ile Tyr
             420                 425                 430        
 Met Asp Thr Asn Pro Asn Phe Gln Ile Ile Ile Gly Tyr His Gly Gly
         435                 440                 445            
 Leu Tyr Asp Pro Leu Thr Lys Leu Val His Met Gly Arg Arg Asp Tyr
     450                 455                 460                
 Asp Val Leu Ala Gly Arg Trp Thr Ser Pro Asp His Glu Leu Trp Lys
 465                 470                 475                 480
 His Leu Ser Ser Ser Asn Val Met Pro Phe Asn Leu Tyr Met Phe Lys
                 485                 490                 495    
 Asn Asn Asn Pro Ile Ser Asn Ser Gln Asp Ile Lys Cys Phe Met Thr
             500                 505                 510        
 Asp Val Asn Ser Trp Leu Leu Thr Phe Gly Phe Gln Leu His Asn Val
         515                 520                 525            
 Ile Pro Gly Tyr Pro Lys Pro Asp Met Asp Ala Met Glu Pro Ser Tyr
     530                 535                 540                
 Glu Leu Ile His Thr Gln Met Lys Thr Gln Glu Trp Asp Asn Ser Lys
 545                 550                 555                 560
 Ser Ile Leu Gly Val Gln Cys Glu Val Gln Lys Gln Leu Lys Ala Phe
                 565                 570                 575    
 Val Thr Leu Glu Arg Phe Asp Gln Leu Tyr Gly Ser Thr Ile Thr Ser
             580                 585                 590        
 Cys Leu Gln Ala Pro Lys Thr Lys Lys Phe Ala Ser Ser Gly Ser Val
         595                 600                 605            
 Phe Gly Lys Gly Val Lys Phe Ala Leu Lys Asp Gly Arg Val Thr Thr
     610                 615                 620                
 Asp Ile Ile Ser Val Ala Asn Glu Asp Gly Arg Arg Val Ala Ala Ile
 625                 630                 635                 640
 Leu Asn His Ala His Tyr Leu Glu Asn Leu His Phe Thr Ile Asp Gly
                 645                 650                 655    
 Val Asp Thr His Tyr Phe Val Lys Pro Gly Pro Ser Glu Gly Asp Leu
             660                 665                 670        
 Ala Ile Leu Gly Leu Ser Gly Gly Arg Arg Thr Leu Glu Asn Gly Val
         675                 680                 685            
 Asn Val Thr Val Ser Gln Ile Asn Thr Val Leu Ser Gly Arg Thr Arg
     690                 695                 700                
 Arg Tyr Thr Asp Ile Gln Leu Gln Tyr Gly Ala Leu Cys Leu Asn Thr
 705                 710                 715                 720
 Arg Tyr Gly Thr Thr Leu Asp Glu Glu Lys Ala Arg Val Leu Glu Leu
                 725                 730                 735    
 Ala Arg Gln Arg Ala Val Arg Gln Ala Trp Ala Arg Glu Gln Gln Arg
             740                 745                 750        
 Leu Arg Glu Gly Glu Glu Gly Leu Arg Ala Trp Thr Glu Gly Glu Lys
         755                 760                 765            
 Gln Gln Val Leu Ser Thr Gly Arg Val Gln Gly Tyr Asp Gly Phe Phe
     770                 775                 780                
 Val Ile Ser Val Glu Gln Tyr Pro Glu Leu Ser Asp Ser Ala Asn Asn
 785                 790                 795                 800
 Ile His Phe Met Arg Gln Ser Glu Met Gly Arg Arg
                 805                 810        



      <210> 973
      <211> 742
      <212> PRT
      <213> Homo sapiens


      <400> 973
 Met Leu Ser Leu Lys Lys Tyr Leu Thr Glu Gly Leu Leu Gln Phe Thr
   1               5                  10                  15    
 Ile Leu Leu Ser Leu Ile Gly Val Arg Val Asp Val Asp Thr Tyr Leu
              20                  25                  30        
 Thr Ser Gln Leu Pro Pro Leu Arg Glu Ile Ile Leu Gly Pro Ser Ser
          35                  40                  45            
 Ala Tyr Thr Gln Thr Gln Phe His Asn Leu Arg Asn Thr Leu Asp Gly
      50                  55                  60                
 Tyr Gly Ile His Pro Lys Ser Ile Asp Leu Asp Asn Tyr Phe Thr Ala
  65                  70                  75                  80
 Arg Arg Leu Leu Ser Gln Val Arg Ala Leu Asp Arg Phe Gln Val Pro
                  85                  90                  95    
 Thr Thr Glu Val Asn Ala Trp Leu Val His Arg Asp Pro Glu Gly Ser
             100                 105                 110        
 Val Ser Gly Ser Gln Pro Asn Ser Gly Leu Ala Leu Glu Ser Ser Ser
         115                 120                 125            
 Gly Leu Gln Asp Val Thr Gly Pro Asp Asn Gly Val Arg Glu Ser Glu
     130                 135                 140                
 Thr Glu Gln Gly Phe Gly Glu Asp Leu Glu Asp Leu Gly Ala Val Ala
 145                 150                 155                 160
 Pro Pro Val Ser Gly Asp Leu Thr Lys Glu Asp Ile Asp Leu Ile Asp
                 165                 170                 175    
 Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Ala Gly Arg Glu Val Phe
             180                 185                 190        
 Asp Tyr Ser His Arg Gln Lys Glu Gln Asp Val Glu Lys Glu Leu Arg
         195                 200                 205            
 Asp Gly Gly Glu Gln Asp Thr Trp Ala Gly Glu Gly Ala Glu Ala Leu
     210                 215                 220                
 Ala Arg Asn Leu Leu Val Asp Gly Glu Thr Gly Glu Ser Phe Pro Ala
 225                 230                 235                 240
 Gln Phe Pro Ala Asp Ile Ser Ser Ile Thr Glu Ala Val Pro Ser Glu
                 245                 250                 255    
 Ser Glu Pro Pro Ala Leu Gln Asn Asn Leu Leu Ser Pro Leu Leu Thr
             260                 265                 270        
 Gly Thr Glu Ser Pro Phe Asp Leu Glu Gln Gln Trp Gln Asp Leu Met
         275                 280                 285            
 Ser Ile Met Glu Met Gln Ala Met Glu Val Asn Thr Ser Ala Ser Glu
     290                 295                 300                
 Ile Leu Tyr Ser Ala Pro Pro Gly Asp Pro Leu Ser Thr Asn Tyr Ser
 305                 310                 315                 320
 Leu Ala Pro Asn Thr Pro Ile Asn Gln Asn Val Ser Leu His Gln Ala
                 325                 330                 335    
 Ser Leu Gly Gly Cys Ser Gln Asp Phe Leu Leu Phe Ser Pro Glu Val
             340                 345                 350        
 Glu Ser Leu Pro Val Ala Ser Ser Ser Thr Leu Leu Pro Leu Ala Pro
         355                 360                 365            
 Ser Asn Ser Thr Ser Leu Asn Ser Thr Phe Gly Ser Thr Asn Leu Thr
     370                 375                 380                
 Gly Leu Phe Phe Pro Pro Gln Leu Asn Gly Thr Ala Asn Asp Thr Ala
 385                 390                 395                 400
 Gly Pro Glu Leu Pro Asp Pro Leu Gly Gly Leu Leu Asp Glu Ala Met
                 405                 410                 415    
 Leu Asp Glu Ile Ser Leu Met Asp Leu Ala Ile Glu Glu Gly Phe Asn
             420                 425                 430        
 Pro Val Gln Ala Ser Gln Leu Glu Glu Glu Phe Asp Ser Asp Ser Gly
         435                 440                 445            
 Leu Ser Leu Asp Ser Ser His Ser Pro Ser Ser Leu Ser Ser Ser Glu
     450                 455                 460                
 Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala
 465                 470                 475                 480
 Ser Ser Ser Ala Ser Ser Ser Phe Ser Glu Glu Gly Ala Val Gly Tyr
                 485                 490                 495    
 Ser Ser Asp Ser Glu Thr Leu Asp Leu Glu Glu Ala Glu Gly Ala Val
             500                 505                 510        
 Gly Tyr Gln Pro Glu Tyr Ser Lys Phe Cys Arg Met Ser Tyr Gln Asp
         515                 520                 525            
 Pro Ala Gln Leu Ser Cys Leu Pro Tyr Leu Glu His Val Gly His Asn
     530                 535                 540                
 His Thr Tyr Asn Met Ala Pro Ser Ala Leu Asp Ser Ala Asp Leu Pro
 545                 550                 555                 560
 Pro Pro Ser Ala Leu Lys Lys Gly Ser Lys Glu Lys Gln Ala Asp Phe
                 565                 570                 575    
 Leu Asp Lys Gln Met Ser Arg Asp Glu His Arg Ala Arg Ala Met Lys
             580                 585                 590        
 Ile Pro Phe Thr Asn Asp Lys Ile Ile Asn Leu Pro Val Glu Glu Phe
         595                 600                 605            
 Asn Glu Leu Leu Ser Lys Tyr Gln Leu Ser Glu Ala Gln Leu Ser Leu
     610                 615                 620                
 Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Met Ala Ala Gln Asn
 625                 630                 635                 640
 Cys Arg Lys Arg Lys Leu Asp Thr Ile Leu Asn Leu Glu Arg Asp Val
                 645                 650                 655    
 Glu Asp Leu Gln Arg Asp Lys Ala Arg Leu Leu Arg Glu Lys Val Glu
             660                 665                 670        
 Phe Leu Arg Ser Leu Arg Gln Met Lys Gln Lys Val Gln Ser Leu Tyr
         675                 680                 685            
 Gln Glu Val Phe Gly Arg Leu Arg Asp Glu Asn Gly Arg Pro Tyr Ser
     690                 695                 700                
 Pro Ser Gln Tyr Ala Leu Gln Tyr Ala Gly Asp Gly Ser Val Leu Leu
 705                 710                 715                 720
 Ile Pro Arg Thr Met Ala Asp Gln Gln Ala Arg Arg Gln Glu Arg Lys
                 725                 730                 735    
 Pro Lys Asp Arg Arg Lys
             740        



      <210> 974
      <211> 1682
      <212> PRT
      <213> Homo sapiens


      <400> 974
 Met Val Lys Gly Met Ala Phe Ser Pro Asp Ser Thr Lys Ile Ala Ile
   1               5                  10                  15    
 Gly Gln Thr Asp Asn Ile Ile Tyr Val Tyr Lys Ile Gly Glu Asp Cys
              20                  25                  30        
 Gly Asp Lys Lys Val Ile Cys Asn Lys Phe Ile His Thr Ser Ala Val
          35                  40                  45            
 Thr Cys Leu Gln Trp Pro Ala Glu Tyr Ile Ile Val Phe Gly Leu Ala
      50                  55                  60                
 Glu Gly Lys Val Arg Leu Ala Asn Thr Lys Thr Asn Lys Ser Ser Thr
  65                  70                  75                  80
 Ile Tyr Gly Thr Glu Ser Tyr Val Val Ser Leu Thr Thr Asn Cys Ser
                  85                  90                  95    
 Gly Lys Gly Ile Leu Ser Gly His Ala Asp Gly Thr Ile Val Arg Tyr
             100                 105                 110        
 Phe Phe Asp Asp Glu Gly Ser Gly Glu Ser Gln Glu Lys Leu Val Asn
         115                 120                 125            
 His Pro Cys Pro Pro Tyr Ala Leu Ala Trp Ala Thr Asn Ser Ile Val
     130                 135                 140                
 Ala Ala Gly Cys Asp Arg Lys Ile Val Ala Tyr Gly Lys Glu Gly His
 145                 150                 155                 160
 Met Leu Gln Thr Phe Asp Tyr Ser Arg Asp Pro Gln Glu Arg Glu Phe
                 165                 170                 175    
 Thr Thr Ala Val Ser Ser Pro Gly Gly Gln Ser Val Val Leu Gly Ser
             180                 185                 190        
 Tyr Asp Arg Leu Arg Val Phe Asn Trp Ile Pro Arg Arg Ser Ile Trp
         195                 200                 205            
 Glu Glu Ala Lys Pro Lys Glu Ile Thr Asn Leu Tyr Thr Ile Thr Ala
     210                 215                 220                
 Leu Ala Trp Lys Arg Asp Gly Ser Arg Leu Cys Val Gly Thr Leu Cys
 225                 230                 235                 240
 Gly Gly Val Glu Gln Phe Asp Cys Cys Leu Arg Arg Ser Ile Tyr Lys
                 245                 250                 255    
 Asn Lys Phe Glu Leu Thr Tyr Val Gly Pro Ser Gln Val Ile Val Lys
             260                 265                 270        
 Asn Leu Ser Ser Gly Thr Arg Val Val Leu Lys Ser His Tyr Gly Tyr
         275                 280                 285            
 Glu Val Glu Glu Val Lys Ile Leu Gly Lys Glu Arg Tyr Leu Val Ala
     290                 295                 300                
 His Thr Ser Glu Thr Leu Leu Leu Gly Asp Leu Asn Thr Asn Arg Leu
 305                 310                 315                 320
 Ser Glu Ile Ala Trp Gln Gly Ser Gly Gly Asn Glu Lys Tyr Phe Phe
                 325                 330                 335    
 Glu Asn Glu Asn Val Cys Met Ile Phe Asn Ala Gly Glu Leu Thr Leu
             340                 345                 350        
 Val Glu Tyr Gly Asn Asn Asp Thr Leu Gly Ser Val Arg Thr Glu Phe
         355                 360                 365            
 Met Asn Pro His Leu Ile Ser Val Arg Ile Asn Glu Arg Cys Gln Arg
     370                 375                 380                
 Gly Thr Glu Asp Asn Lys Lys Leu Ala Tyr Leu Ile Asp Ile Lys Thr
 385                 390                 395                 400
 Ile Ala Ile Val Asp Leu Ile Gly Gly Tyr Asn Ile Gly Thr Val Ser
                 405                 410                 415    
 His Glu Ser Arg Val Asp Trp Leu Glu Leu Asn Glu Thr Gly His Lys
             420                 425                 430        
 Leu Leu Phe Arg Asp Arg Lys Leu Arg Leu His Leu Tyr Asp Ile Glu
         435                 440                 445            
 Ser Cys Ser Lys Thr Met Ile Leu Asn Phe Cys Ser Tyr Met Gln Trp
     450                 455                 460                
 Val Pro Gly Ser Asp Val Leu Val Ala Gln Asn Arg Asn Ser Leu Cys
 465                 470                 475                 480
 Val Trp Tyr Asn Ile Glu Ala Pro Glu Arg Val Thr Met Phe Thr Ile
                 485                 490                 495    
 Arg Gly Asp Val Ile Gly Leu Glu Arg Gly Gly Gly Lys Thr Glu Val
             500                 505                 510        
 Met Val Met Glu Gly Val Thr Thr Val Ala Tyr Thr Leu Asp Glu Gly
         515                 520                 525            
 Leu Ile Glu Phe Gly Thr Ala Ile Asp Asp Gly Asn Tyr Ile Arg Ala
     530                 535                 540                
 Thr Ala Phe Leu Glu Thr Leu Glu Met Thr Pro Glu Thr Glu Ala Met
 545                 550                 555                 560
 Trp Lys Thr Leu Ser Lys Leu Ala Leu Glu Ala Arg Gln Leu His Ile
                 565                 570                 575    
 Ala Glu Arg Cys Phe Ser Ala Leu Gly Gln Val Ala Lys Ala Arg Phe
             580                 585                 590        
 Leu His Glu Thr Asn Glu Ile Ala Asp Gln Val Ser Arg Glu Tyr Gly
         595                 600                 605            
 Gly Glu Gly Thr Asp Phe Tyr Gln Val Arg Ala Arg Leu Ala Met Leu
     610                 615                 620                
 Glu Lys Asn Tyr Lys Leu Ala Glu Met Ile Phe Leu Glu Gln Asn Ala
 625                 630                 635                 640
 Val Glu Glu Ala Met Gly Met Tyr Gln Glu Leu His Arg Trp Asp Glu
                 645                 650                 655    
 Cys Ile Ala Val Ala Glu Ala Lys Gly His Pro Ala Leu Glu Lys Leu
             660                 665                 670        
 Arg Arg Ser Tyr Tyr Gln Trp Leu Met Asp Thr Gln Gln Glu Glu Arg
         675                 680                 685            
 Ala Gly Glu Leu Gln Glu Ser Gln Gly Asp Gly Leu Ala Ala Ile Ser
     690                 695                 700                
 Leu Tyr Leu Lys Ala Gly Leu Pro Ala Lys Ala Ala Arg Leu Val Leu
 705                 710                 715                 720
 Thr Arg Glu Glu Leu Leu Ala Asn Thr Glu Leu Val Glu His Ile Thr
                 725                 730                 735    
 Ala Ala Leu Ile Lys Gly Glu Leu Tyr Glu Arg Ala Gly Asp Leu Phe
             740                 745                 750        
 Glu Lys Ile His Asn Pro Gln Lys Ala Leu Glu Cys Tyr Arg Lys Gly
         755                 760                 765            
 Asn Ala Phe Met Lys Ala Val Glu Leu Ala Arg Leu Ala Phe Pro Val
     770                 775                 780                
 Glu Val Val Lys Leu Glu Glu Ala Trp Gly Asp His Leu Val Gln Gln
 785                 790                 795                 800
 Lys Gln Leu Asp Ala Ala Ile Asn His Tyr Ile Glu Ala Arg Cys Ser
                 805                 810                 815    
 Ile Lys Ala Ile Glu Ala Ala Leu Gly Ala Arg Gln Trp Lys Lys Ala
             820                 825                 830        
 Ile Tyr Ile Leu Asp Leu Gln Asp Arg Asn Thr Ala Ser Lys Tyr Tyr
         835                 840                 845            
 Pro Leu Val Ala Gln His Tyr Ala Ser Leu Gln Glu Tyr Glu Ile Ala
     850                 855                 860                
 Glu Glu Leu Tyr Thr Lys Gly Asp Arg Thr Lys Asp Ala Ile Asp Met
 865                 870                 875                 880
 Tyr Thr Gln Ala Gly Arg Trp Glu Gln Ala His Lys Leu Ala Met Lys
                 885                 890                 895    
 Cys Met Arg Pro Glu Asp Val Ser Val Leu Tyr Ile Thr Gln Ala Gln
             900                 905                 910        
 Glu Met Glu Lys Gln Gly Lys Tyr Arg Glu Ala Glu Arg Leu Tyr Val
         915                 920                 925            
 Thr Val Gln Glu Pro Asp Leu Ala Ile Thr Met Tyr Lys Lys His Lys
     930                 935                 940                
 Leu Tyr Asp Asp Met Ile Arg Leu Val Gly Lys His His Pro Asp Leu
 945                 950                 955                 960
 Leu Ser Asp Thr His Leu His Leu Gly Lys Glu Leu Glu Ala Glu Gly
                 965                 970                 975    
 Arg Leu Gln Glu Ala Glu Tyr His Tyr Leu Glu Ala Gln Glu Trp Lys
             980                 985                 990        
 Ala Thr Val Asn Met Tyr Arg Ala Ser Gly Leu Trp Glu Glu Ala Tyr
         995                1000                1005            
 Arg Val Ala Arg Thr Gln Gly Gly Ala Asn Ala His Lys His Val Ala
    1010                1015                1020                
 Tyr Leu Trp Ala Lys Ser Leu Gly Gly Glu Ala Ala Val Arg Leu Leu
1025                1030                1035                1040
 Asn Lys Leu Gly Leu Leu Glu Ala Ala Val Asp His Ala Ala Asp Asn
                1045                1050                1055    
 Cys Ser Phe Glu Phe Ala Phe Glu Leu Ser Arg Leu Ala Leu Lys His
            1060                1065                1070        
 Lys Thr Pro Glu Val His Leu Lys Tyr Ala Met Phe Leu Glu Asp Glu
        1075                1080                1085            
 Gly Lys Phe Glu Glu Ala Glu Ala Glu Phe Ile Arg Ala Gly Lys Pro
    1090                1095                1100                
 Lys Glu Ala Val Leu Met Phe Val His Asn Gln Asp Trp Glu Ala Ala
1105                1110                1115                1120
 Gln Arg Val Ala Glu Ala His Asp Pro Asp Ser Val Ala Glu Val Leu
                1125                1130                1135    
 Val Gly Gln Ala Arg Gly Ala Leu Glu Glu Lys Asp Phe Gln Lys Ala
            1140                1145                1150        
 Glu Gly Leu Leu Leu Arg Ala Gln Arg Pro Gly Leu Ala Leu Asn Tyr
        1155                1160                1165            
 Tyr Lys Glu Ala Gly Leu Trp Ser Asp Ala Leu Arg Ile Cys Lys Asp
    1170                1175                1180                
 Tyr Val Pro Ser Gln Leu Glu Ala Leu Gln Glu Glu Tyr Glu Arg Glu
1185                1190                1195                1200
 Ala Thr Lys Lys Gly Ala Arg Gly Val Glu Gly Phe Val Glu Gln Ala
                1205                1210                1215    
 Arg His Trp Glu Gln Ala Gly Glu Tyr Ser Arg Ala Val Asp Cys Tyr
            1220                1225                1230        
 Leu Lys Val Arg Asp Ser Gly Asn Ser Gly Leu Ala Glu Lys Cys Trp
        1235                1240                1245            
 Met Lys Ala Ala Glu Leu Ser Ile Lys Phe Leu Pro Pro Gln Arg Asn
    1250                1255                1260                
 Met Glu Val Val Leu Ala Val Gly Pro Gln Leu Ile Gly Ile Gly Lys
1265                1270                1275                1280
 His Ser Ala Ala Ala Glu Leu Tyr Leu Asn Leu Asp Leu Val Lys Glu
                1285                1290                1295    
 Ala Ile Asp Ala Phe Ile Glu Gly Glu Glu Trp Asn Lys Ala Lys Arg
            1300                1305                1310        
 Val Ala Lys Glu Leu Asp Pro Arg Tyr Glu Asp Tyr Val Asp Gln His
        1315                1320                1325            
 Tyr Lys Glu Phe Leu Lys Asn Gln Gly Lys Val Asp Ser Leu Val Gly
    1330                1335                1340                
 Val Asp Val Ile Ala Ala Leu Asp Leu Tyr Val Glu Gln Gly Gln Trp
1345                1350                1355                1360
 Asp Lys Cys Ile Glu Thr Ala Thr Lys Gln Asn Tyr Lys Ile Leu His
                1365                1370                1375    
 Lys Tyr Val Ala Leu Tyr Ala Thr His Leu Ile Arg Glu Gly Ser Ser
            1380                1385                1390        
 Ala Gln Ala Leu Ala Leu Tyr Val Gln His Gly Ala Pro Ala Asn Pro
        1395                1400                1405            
 Gln Asn Phe Asn Ile Tyr Lys Arg Ile Phe Thr Asp Met Val Ser Ser
    1410                1415                1420                
 Pro Gly Thr Asn Cys Ala Glu Ala Tyr His Ser Trp Ala Asp Leu Arg
1425                1430                1435                1440
 Asp Val Leu Phe Asn Leu Phe Glu Asn Leu Val Lys Ser Ser Glu Ala
                1445                1450                1455    
 Asn Ser Pro Ala His Glu Glu Phe Lys Thr Met Leu Leu Ile Ala His
            1460                1465                1470        
 Tyr Tyr Ala Thr Arg Ser Ala Ala Gln Ser Val Lys Gln Leu Glu Thr
        1475                1480                1485            
 Val Ala Ala Arg Leu Ser Val Ser Leu Leu Arg His Thr Gln Leu Leu
    1490                1495                1500                
 Pro Val Asp Lys Ala Phe Tyr Glu Ala Gly Ile Ala Ala Lys Ala Val
1505                1510                1515                1520
 Gly Trp Asp Asn Met Ala Phe Ile Phe Leu Asn Arg Phe Leu Asp Leu
                1525                1530                1535    
 Thr Asp Ala Ile Glu Glu Gly Thr Leu Asp Gly Leu Asp His Ser Asp
            1540                1545                1550        
 Phe Gln Asp Thr Asp Ile Pro Phe Glu Val Pro Leu Pro Ala Lys Gln
        1555                1560                1565            
 His Val Pro Glu Ala Glu Arg Glu Glu Val Arg Asp Trp Val Leu Thr
    1570                1575                1580                
 Val Ser Met Asp Gln Arg Leu Glu Gln Val Leu Pro Arg Asp Glu Arg
1585                1590                1595                1600
 Gly Ala Tyr Glu Ala Ser Leu Val Ala Ala Ser Thr Gly Val Arg Ala
                1605                1610                1615    
 Leu Pro Cys Leu Ile Thr Gly Tyr Pro Ile Leu Arg Asn Lys Ile Glu
            1620                1625                1630        
 Phe Lys Arg Pro Gly Lys Ala Ala Asn Lys Asp Asn Trp Asn Lys Phe
        1635                1640                1645            
 Leu Met Ala Ile Lys Thr Ser His Ser Pro Val Cys Gln Asp Val Leu
    1650                1655                1660                
 Lys Phe Ile Ser Gln Trp Cys Gly Gly Leu Pro Ser Thr Ser Phe Ser
1665                1670                1675                1680
 Phe Gln
        



      <210> 975
      <211> 468
      <212> PRT
      <213> Homo sapiens


      <400> 975
 Met Ala His Arg Asp Ser Glu Met Lys Glu Glu Cys Leu Arg Glu Asp
   1               5                  10                  15    
 Leu Lys Phe Tyr Phe Met Ser Pro Cys Glu Lys Tyr Arg Ala Arg Arg
              20                  25                  30        
 Gln Ile Pro Trp Lys Leu Gly Leu Gln Ile Leu Lys Ile Val Met Val
          35                  40                  45            
 Thr Thr Gln Tyr His Gln Leu Lys Asp Ile Thr Leu Gly Thr Leu Gly
      50                  55                  60                
 Tyr Gly Glu Asn Glu Asp Asn Arg Ile Gly Leu Lys Val Cys Lys Gln
  65                  70                  75                  80
 His Tyr Lys Lys Gly Thr Met Phe Pro Ser Asn Glu Thr Leu Asn Ile
                  85                  90                  95    
 Asp Asn Asp Val Glu Leu Asp Cys Val Gln Leu Asp Leu Gln Asp Leu
             100                 105                 110        
 Ser Lys Lys Pro Pro Asp Trp Lys Asn Ser Ser Phe Phe Arg Leu Glu
         115                 120                 125            
 Phe Tyr Arg Tyr Ala Glu Ile Arg Gly Ile Phe Ser Lys Ser Lys Tyr
     130                 135                 140                
 Arg Leu Pro Ile Phe Cys Glu Lys Lys Leu Thr Phe Val Lys Tyr Val
 145                 150                 155                 160
 Ile Trp Asn Ile Ile Ile Lys Ile Lys Met Met Glu Ile Ser Lys Leu
                 165                 170                 175    
 Val Ser Gln Met His Phe Gln Asn Thr Gln Lys Asn Ala Gln Tyr Val
             180                 185                 190        
 Leu Val Phe Asp Ala Phe Val Ile Val Ile Cys Leu Ala Ser Leu Ile
         195                 200                 205            
 Leu Cys Thr Arg Ser Ile Val Leu Ala Leu Arg Leu Arg Lys Arg Phe
     210                 215                 220                
 Leu Asn Phe Phe Leu Glu Lys Tyr Lys Arg Pro Val Cys Asp Thr Asp
 225                 230                 235                 240
 Gln Trp Glu Phe Ile Asn Gly Trp Tyr Val Leu Val Ile Ile Ser Asp
                 245                 250                 255    
 Leu Met Thr Ile Ile Gly Ser Ile Leu Lys Met Glu Ile Lys Ala Lys
             260                 265                 270        
 Asn Leu Thr Asn Tyr Asp Leu Cys Ser Ile Phe Leu Gly Thr Ser Thr
         275                 280                 285            
 Leu Leu Val Trp Val Gly Val Ile Arg Tyr Leu Gly Tyr Phe Gln Ala
     290                 295                 300                
 Tyr Asn Val Leu Ile Leu Thr Met Gln Ala Ser Leu Pro Lys Val Leu
 305                 310                 315                 320
 Arg Phe Cys Ala Cys Ala Gly Met Ile Tyr Leu Gly Tyr Thr Phe Cys
                 325                 330                 335    
 Gly Trp Ile Val Leu Gly Pro Tyr His Asp Lys Phe Glu Asn Leu Asn
             340                 345                 350        
 Thr Val Ala Glu Cys Leu Phe Ser Leu Val Asn Gly Asp Asp Met Phe
         355                 360                 365            
 Ala Thr Phe Ala Gln Ile Gln Gln Lys Ser Ile Leu Val Trp Leu Phe
     370                 375                 380                
 Ser Arg Leu Tyr Leu Tyr Ser Phe Ile Ser Leu Phe Ile Tyr Met Ile
 385                 390                 395                 400
 Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp Ser Tyr Asp Thr Ile Lys
                 405                 410                 415    
 Lys Phe Gln Gln Asn Gly Phe Pro Glu Thr Asp Leu Gln Glu Phe Leu
             420                 425                 430        
 Lys Glu Cys Ser Ser Lys Glu Glu Tyr Gln Lys Glu Ser Ser Ala Phe
         435                 440                 445            
 Leu Ser Cys Ile Cys Cys Arg Arg Arg Lys Arg Ser Asp Asp His Leu
     450                 455                 460                
 Ile Pro Ile Ser
 465            



      <210> 976
      <211> 542
      <212> PRT
      <213> Homo sapiens


      <400> 976
 Met Ala His Arg Asp Ser Glu Met Lys Glu Glu Cys Leu Arg Glu Asp
   1               5                  10                  15    
 Leu Lys Phe Tyr Phe Met Ser Pro Cys Glu Lys Tyr Arg Ala Arg Arg
              20                  25                  30        
 Gln Ile Pro Trp Lys Leu Gly Leu Gln Ile Leu Lys Ile Val Met Val
          35                  40                  45            
 Thr Thr Gln Leu Val Arg Phe Gly Leu Ser Asn Gln Leu Val Val Ala
      50                  55                  60                
 Phe Lys Glu Asp Asn Thr Val Ala Phe Lys His Leu Phe Leu Lys Gly
  65                  70                  75                  80
 Tyr Ser Gly Thr Asp Glu Asp Asp Tyr Ser Cys Ser Val Tyr Thr Gln
                  85                  90                  95    
 Glu Asp Ala Tyr Glu Ser Ile Phe Phe Ala Ile Asn Gln Tyr His Gln
             100                 105                 110        
 Leu Lys Asp Ile Thr Leu Gly Thr Leu Gly Tyr Gly Glu Asn Glu Asp
         115                 120                 125            
 Asn Arg Ile Gly Leu Lys Val Cys Lys Gln His Tyr Lys Lys Gly Thr
     130                 135                 140                
 Met Phe Pro Ser Asn Glu Thr Leu Asn Ile Asp Asn Asp Val Glu Leu
 145                 150                 155                 160
 Asp Cys Val Gln Leu Asp Leu Gln Asp Leu Ser Lys Lys Pro Pro Asp
                 165                 170                 175    
 Trp Lys Asn Ser Ser Phe Phe Arg Leu Glu Phe Tyr Arg Leu Leu Gln
             180                 185                 190        
 Val Glu Ile Ser Phe His Leu Lys Gly Ile Asp Leu Gln Thr Ile His
         195                 200                 205            
 Ser Arg Glu Leu Pro Asp Cys Tyr Val Phe Gln Asn Thr Ala Ser Ile
     210                 215                 220                
 Phe Ile Ile Phe Asp Asn Lys Ala His Ser Gly Lys Ile Lys Ile Tyr
 225                 230                 235                 240
 Phe Asp Ser Asp Ala Lys Ile Glu Glu Cys Lys Asp Leu Asn Ile Phe
                 245                 250                 255    
 Gly Ser Thr Gln Lys Asn Ala Gln Tyr Val Leu Val Phe Asp Ala Phe
             260                 265                 270        
 Val Ile Val Ile Cys Leu Ala Ser Leu Ile Leu Cys Thr Arg Ser Ile
         275                 280                 285            
 Val Leu Ala Leu Arg Leu Arg Lys Arg Phe Leu Asn Phe Phe Leu Glu
     290                 295                 300                
 Lys Tyr Lys Arg Pro Val Cys Asp Thr Asp Gln Trp Glu Phe Ile Asn
 305                 310                 315                 320
 Gly Trp Tyr Val Leu Val Ile Ile Ser Asp Leu Met Thr Ile Ile Gly
                 325                 330                 335    
 Ser Ile Leu Lys Met Glu Ile Lys Ala Lys Asn Leu Thr Asn Tyr Asp
             340                 345                 350        
 Leu Cys Ser Ile Phe Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly
         355                 360                 365            
 Val Ile Arg Tyr Leu Gly Tyr Phe Gln Ala Tyr Asn Val Leu Ile Leu
     370                 375                 380                
 Thr Met Gln Ala Ser Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala
 385                 390                 395                 400
 Gly Met Ile Tyr Leu Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly
                 405                 410                 415    
 Pro Tyr His Asp Lys Phe Glu Asn Leu Asn Thr Val Ala Glu Cys Leu
             420                 425                 430        
 Phe Ser Leu Val Asn Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile
         435                 440                 445            
 Gln Gln Lys Ser Ile Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr
     450                 455                 460                
 Ser Phe Ile Ser Leu Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala
 465                 470                 475                 480
 Leu Ile Thr Asp Ser Tyr Asp Thr Ile Lys Lys Phe Gln Gln Asn Gly
                 485                 490                 495    
 Phe Pro Glu Thr Asp Leu Gln Glu Phe Leu Lys Glu Cys Ser Ser Lys
             500                 505                 510        
 Glu Glu Tyr Gln Lys Glu Ser Ser Ala Phe Leu Ser Cys Ile Cys Cys
         515                 520                 525            
 Arg Arg Arg Lys Arg Ser Asp Asp His Leu Ile Pro Ile Ser
     530                 535                 540        



      <210> 977
      <211> 2566
      <212> PRT
      <213> Homo sapiens


      <400> 977
 Met Glu Val Leu Gln Cys Asp Gly Cys Asp Phe Arg Ala Pro Ser Tyr
   1               5                  10                  15    
 Glu Asp Leu Lys Ala His Ile Gln Asp Val His Thr Ala Phe Leu Gln
              20                  25                  30        
 Pro Thr Asp Val Ala Glu Asp Asn Val Asn Glu Leu Arg Cys Gly Ser
          35                  40                  45            
 Val Asn Ala Ser Asn Gln Thr Glu Val Glu Phe Ser Ser Ile Lys Asp
      50                  55                  60                
 Glu Phe Ala Ile Ala Glu Asp Leu Ser Gly Gln Asn Ala Thr Ser Leu
  65                  70                  75                  80
 Gly Thr Gly Gly Tyr Tyr Gly His Ser Pro Gly Tyr Tyr Gly Gln His
                  85                  90                  95    
 Ile Ala Ala Asn Pro Lys Pro Thr Asn Lys Phe Phe Gln Cys Lys Phe
             100                 105                 110        
 Cys Val Arg Tyr Phe Arg Ser Lys Asn Leu Leu Ile Glu His Thr Arg
         115                 120                 125            
 Lys Val His Gly Ala Gln Ala Glu Gly Ser Ser Ser Gly Pro Pro Val
     130                 135                 140                
 Pro Gly Ser Leu Asn Tyr Asn Ile Met Met His Glu Gly Phe Gly Lys
 145                 150                 155                 160
 Val Phe Ser Cys Gln Phe Cys Thr Tyr Lys Ser Pro Arg Arg Ala Arg
                 165                 170                 175    
 Ile Ile Lys His Gln Lys Met Tyr His Lys Asn Asn Leu Lys Glu Thr
             180                 185                 190        
 Thr Ala Pro Pro Pro Ala Pro Ala Pro Met Pro Asp Pro Val Val Pro
         195                 200                 205            
 Pro Val Ser Leu Gln Asp Pro Cys Lys Glu Leu Pro Ala Glu Val Val
     210                 215                 220                
 Glu Arg Ser Ile Leu Glu Ser Met Val Lys Pro Leu Thr Lys Ser Arg
 225                 230                 235                 240
 Gly Asn Phe Cys Cys Glu Trp Cys Ser Tyr Gln Thr Pro Arg Arg Glu
                 245                 250                 255    
 Arg Trp Cys Asp His Met Met Asn Lys His Arg Ser Met Val Lys Ile
             260                 265                 270        
 Leu Ser Ser Leu Arg Gln Gln Gln Glu Gly Thr Asn Leu Pro Asp Val
         275                 280                 285            
 Pro Asn Lys Ser Ala Pro Ser Pro Thr Ser Asn Ser Thr Tyr Leu Thr
     290                 295                 300                
 Met Asn Ala Ala Ser Arg Glu Ile Pro Asn Thr Thr Val Ser Asn Phe
 305                 310                 315                 320
 Arg Gly Ser Met Gly Asn Ser Ile Met Arg Pro Asn Ser Ser Ala Ser
                 325                 330                 335    
 Lys Phe Ser Pro Met Ser Tyr Pro Gln Met Lys Pro Lys Ser Pro His
             340                 345                 350        
 Asn Ser Gly Leu Val Asn Leu Thr Glu Arg Ser Arg Tyr Gly Met Thr
         355                 360                 365            
 Asp Met Thr Asn Ser Ser Ala Asp Leu Glu Thr Asn Ser Met Leu Asn
     370                 375                 380                
 Asp Ser Ser Ser Asp Glu Glu Leu Asn Glu Ile Asp Ser Glu Asn Gly
 385                 390                 395                 400
 Leu Ser Ala Met Asp His Gln Thr Ser Gly Leu Ser Ala Glu Gln Leu
                 405                 410                 415    
 Met Gly Ser Asp Gly Asn Lys Leu Leu Glu Thr Lys Gly Ile Pro Phe
             420                 425                 430        
 Arg Arg Phe Met Asn Arg Phe Gln Cys Pro Phe Cys Pro Phe Leu Thr
         435                 440                 445            
 Met His Arg Arg Ser Ile Ser Arg His Ile Glu Asn Ile His Leu Ser
     450                 455                 460                
 Gly Lys Thr Ala Val Tyr Lys Cys Asp Glu Cys Pro Phe Thr Cys Lys
 465                 470                 475                 480
 Ser Ser Leu Lys Leu Gly Ala His Lys Gln Cys His Thr Gly Thr Thr
                 485                 490                 495    
 Ser Asp Trp Asp Ala Val Asn Ser Gln Ser Glu Ser Ile Ser Ser Ser
             500                 505                 510        
 Leu Asn Glu Gly Val Val Ser Tyr Glu Ser Ser Ser Ile Asn Gly Arg
         515                 520                 525            
 Lys Ser Gly Val Met Leu Asp Pro Leu Gln Gln Gln Gln Pro Pro Gln
     530                 535                 540                
 Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser Gln Pro Gln Pro Leu
 545                 550                 555                 560
 Gln Gln Pro Gln Pro Pro Gln Leu Gln Pro Pro His Gln Val Pro Pro
                 565                 570                 575    
 Gln Pro Gln Thr Gln Pro Pro Pro Thr Gln Gln Pro Gln Pro Pro Thr
             580                 585                 590        
 Gln Ala Ala Pro Leu His Pro Tyr Lys Cys Thr Met Cys Asn Tyr Ser
         595                 600                 605            
 Thr Thr Thr Leu Lys Gly Leu Arg Val His Gln Gln His Lys His Ser
     610                 615                 620                
 Phe Cys Asp Asn Leu Pro Lys Phe Glu Gly Gln Pro Ser Ser Leu Pro
 625                 630                 635                 640
 Leu Glu Asn Glu Thr Asp Ser His Pro Ser Ser Ser Asn Thr Val Lys
                 645                 650                 655    
 Lys Ser Gln Thr Ser Ile Leu Gly Leu Ser Ser Lys Asn Asn Phe Val
             660                 665                 670        
 Ala Lys Ala Ser Arg Lys Leu Ala Asn Asp Phe Pro Leu Asp Leu Ser
         675                 680                 685            
 Pro Val Lys Lys Arg Thr Arg Ile Asp Glu Ile Ala Ser Asn Leu Gln
     690                 695                 700                
 Ser Lys Ile Asn Gln Thr Lys Gln Gln Glu Asp Ala Val Ile Asn Val
 705                 710                 715                 720
 Glu Asp Asp Glu Lys Glu Glu Glu Asp Asn Glu Val Glu Ile Glu Val
                 725                 730                 735    
 Glu Leu Asp Arg Glu Glu Glu Pro Thr Glu Pro Ile Ile Glu Val Pro
             740                 745                 750        
 Thr Ser Phe Ser Ala Gln Gln Ile Trp Val Arg Asp Thr Ser Glu Pro
         755                 760                 765            
 Gln Lys Glu Pro Asn Phe Arg Asn Ile Thr His Asp Tyr Asn Ala Thr
     770                 775                 780                
 Asn Gly Ala Glu Ile Glu Leu Thr Leu Ser Glu Asp Glu Glu Asp Tyr
 785                 790                 795                 800
 Tyr Gly Ser Ser Thr Asn Leu Lys Asp His Gln Val Ser Asn Thr Ala
                 805                 810                 815    
 Leu Leu Asn Thr Gln Thr Pro Ile Tyr Gly Thr Glu His Asn Ser Glu
             820                 825                 830        
 Asn Thr Asp Phe Gly Asp Ser Gly Arg Leu Tyr Tyr Cys Lys His Cys
         835                 840                 845            
 Asp Phe Asn Asn Lys Ser Ala Arg Ser Val Ser Thr His Tyr Gln Arg
     850                 855                 860                
 Met His Pro Tyr Ile Lys Phe Ser Phe Arg Tyr Ile Leu Asp Pro Asn
 865                 870                 875                 880
 Asp His Ser Ala Val Tyr Arg Cys Leu Glu Cys Tyr Ile Asp Tyr Thr
                 885                 890                 895    
 Asn Phe Glu Asp Leu Gln Gln His Tyr Gly Glu His His Pro Glu Ala
             900                 905                 910        
 Met Asn Val Leu Asn Phe Asp His Ser Asp Leu Ile Tyr Arg Cys Arg
         915                 920                 925            
 Phe Cys Ser Tyr Thr Ser Pro Asn Val Arg Ser Leu Met Pro His Tyr
     930                 935                 940                
 Gln Arg Met His Pro Thr Val Lys Ile Asn Asn Ala Met Ile Phe Ser
 945                 950                 955                 960
 Ser Tyr Val Val Glu Gln Gln Glu Gly Leu Asn Thr Glu Ser Gln Thr
                 965                 970                 975    
 Leu Arg Glu Ile Leu Asn Ser Ala Pro Lys Asn Met Ala Thr Ser Thr
             980                 985                 990        
 Pro Val Ala Arg Gly Gly Gly Leu Pro Ala Thr Phe Asn Lys Asn Thr
         995                1000                1005            
 Pro Lys Thr Phe Thr Pro Glu Cys Glu Asn Gln Lys Asp Pro Leu Val
    1010                1015                1020                
 Asn Thr Val Val Val Tyr Asp Cys Asp Val Cys Ser Phe Ala Ser Pro
1025                1030                1035                1040
 Asn Met His Ser Val Leu Val His Tyr Gln Lys Lys His Pro Glu Glu
                1045                1050                1055    
 Lys Ala Ser Tyr Phe Arg Ile Gln Lys Thr Met Arg Met Val Ser Val
            1060                1065                1070        
 Asp Arg Gly Ser Ala Leu Ser Gln Leu Ser Phe Glu Val Gly Ala Pro
        1075                1080                1085            
 Met Ser Pro Lys Met Ser Asn Met Gly Ser Pro Pro Pro Pro Gln Pro
    1090                1095                1100                
 Pro Pro Pro Asp Leu Ser Thr Glu Leu Tyr Tyr Cys Lys His Cys Ser
1105                1110                1115                1120
 Tyr Ser Asn Arg Ser Val Val Gly Val Leu Val His Tyr Gln Lys Arg
                1125                1130                1135    
 His Pro Glu Ile Lys Val Thr Ala Lys Tyr Ile Arg Gln Ala Pro Pro
            1140                1145                1150        
 Thr Ala Ala Met Met Arg Gly Val Glu Gly Pro Gln Gly Ser Pro Arg
        1155                1160                1165            
 Pro Pro Ala Pro Ile Gln Gln Leu Asn Arg Ser Ser Ser Glu Arg Asp
    1170                1175                1180                
 Gly Pro Pro Val Glu Asn Glu Met Phe Phe Cys Gln His Cys Asp Tyr
1185                1190                1195                1200
 Gly Asn Arg Thr Val Lys Gly Val Leu Ile His Tyr Gln Lys Lys His
                1205                1210                1215    
 Arg Asp Phe Lys Ala Asn Ala Asp Val Ile Arg Gln His Thr Ala Thr
            1220                1225                1230        
 Ile Arg Ser Leu Cys Asp Arg Asn Gln Lys Lys Pro Ala Ser Cys Val
        1235                1240                1245            
 Leu Val Ser Pro Ser Asn Leu Glu Arg Asp Lys Thr Lys Leu Arg Ala
    1250                1255                1260                
 Leu Lys Cys Arg Gln Cys Ser Tyr Thr Ser Pro Tyr Phe Tyr Ala Leu
1265                1270                1275                1280
 Arg Lys His Ile Lys Lys Asp His Pro Ala Leu Lys Ala Thr Val Thr
                1285                1290                1295    
 Ser Ile Met Arg Trp Ala Phe Leu Asp Gly Leu Ile Glu Ala Gly Tyr
            1300                1305                1310        
 His Cys Glu Trp Cys Ile Tyr Ser His Thr Glu Pro Asn Gly Leu Leu
        1315                1320                1325            
 Leu His Tyr Gln Arg Arg His Pro Glu His Tyr Val Asp Tyr Thr Tyr
    1330                1335                1340                
 Met Ala Thr Lys Leu Trp Ala Gly Pro Asp Pro Ser Pro Pro Ser Leu
1345                1350                1355                1360
 Thr Met Pro Ala Glu Ala Lys Thr Tyr Arg Cys Arg Asp Cys Val Phe
                1365                1370                1375    
 Glu Ala Val Ser Ile Trp Asp Thr Thr Asn His Tyr Gln Ala Phe His
            1380                1385                1390        
 Pro Trp Ala Met Asn Gly Asp Glu Ser Val Leu Leu Asp Ile Ile Lys
        1395                1400                1405            
 Glu Lys Asp Ala Val Glu Lys Pro Ile Leu Ser Ser Glu Glu Leu Ala
    1410                1415                1420                
 Gly Pro Val Asn Cys Glu Asn Ser Ile Pro Thr Pro Phe Pro Glu Gln
1425                1430                1435                1440
 Glu Ala Glu Cys Pro Glu Asp Ala Arg Leu Ser Pro Glu Lys Ser Leu
                1445                1450                1455    
 Gln Leu Ala Ser Ala Asn Pro Ala Ile Ser Ser Thr Pro Tyr Gln Cys
            1460                1465                1470        
 Thr Val Cys Gln Ser Glu Tyr Asn Asn Leu His Gly Leu Leu Thr His
        1475                1480                1485            
 Tyr Gly Lys Lys His Pro Gly Met Lys Val Lys Ala Ala Asp Phe Ala
    1490                1495                1500                
 Gln Asp Ile Asp Ile Asn Pro Gly Ala Val Tyr Lys Cys Arg His Cys
1505                1510                1515                1520
 Pro Tyr Ile Asn Thr Arg Ile His Gly Val Leu Thr His Tyr Gln Lys
                1525                1530                1535    
 Arg His Pro Ser Ile Lys Val Thr Ala Glu Asp Phe Val His Asp Val
            1540                1545                1550        
 Glu Gln Ser Ala Asp Ile Ser Gln Asn Asp Val Glu Glu Thr Ser Arg
        1555                1560                1565            
 Ile Phe Lys Gln Gly Tyr Gly Ala Tyr Arg Cys Lys Leu Cys Pro Tyr
    1570                1575                1580                
 Thr His Gly Thr Leu Glu Lys Leu Lys Ile His Tyr Glu Lys Tyr His
1585                1590                1595                1600
 Asn Gln Pro Glu Phe Asp Val Phe Ser Gln Ser Pro Pro Lys Leu Pro
                1605                1610                1615    
 Val Pro Leu Glu Pro Glu Met Thr Thr Glu Val Ser Pro Ser Gln Val
            1620                1625                1630        
 Ser Ile Thr Glu Glu Glu Val Gly Glu Glu Pro Val Ser Thr Ser His
        1635                1640                1645            
 Phe Ser Thr Ser His Leu Val Ser His Thr Val Phe Arg Cys Gln Leu
    1650                1655                1660                
 Cys Lys Tyr Phe Cys Ser Thr Arg Lys Gly Ile Ala Arg His Tyr Arg
1665                1670                1675                1680
 Ile Lys His Asn Asn Val Arg Ala Gln Pro Glu Gly Lys Asn Asn Leu
                1685                1690                1695    
 Phe Lys Cys Ala Leu Cys Ala Tyr Thr Asn Pro Ile Arg Lys Gly Leu
            1700                1705                1710        
 Ala Ala His Tyr Gln Lys Arg His Asp Ile Asp Ala Tyr Tyr Thr His
        1715                1720                1725            
 Cys Leu Ala Ala Ser Arg Thr Ile Ser Asp Lys Pro Asn Lys Val Ile
    1730                1735                1740                
 Ile Pro Ser Pro Pro Lys Asp Asp Ser Pro Gln Leu Ser Glu Glu Leu
1745                1750                1755                1760
 Arg Arg Ala Val Glu Lys Lys Lys Cys Ser Leu Cys Ser Phe Gln Ser
                1765                1770                1775    
 Phe Ser Lys Lys Gly Ile Val Ser His Tyr Met Lys Arg His Pro Gly
            1780                1785                1790        
 Val Phe Pro Lys Lys Gln His Ala Ser Lys Leu Gly Gly Tyr Phe Thr
        1795                1800                1805            
 Ala Val Tyr Ala Asp Glu His Glu Lys Pro Thr Leu Met Glu Glu Glu
    1810                1815                1820                
 Glu Arg Gly Asn Phe Glu Lys Ala Glu Val Glu Gly Glu Ala Gln Glu
1825                1830                1835                1840
 Ile Glu Trp Leu Pro Phe Arg Cys Ile Lys Cys Phe Lys Leu Ser Phe
                1845                1850                1855    
 Ser Thr Ala Glu Leu Leu Cys Met His Tyr Thr Asp His His Ser Arg
            1860                1865                1870        
 Asp Leu Lys Arg Asp Phe Ile Ile Leu Gly Asn Gly Pro Arg Leu Gln
        1875                1880                1885            
 Asn Ser Thr Tyr Gln Cys Lys His Cys Asp Ser Lys Leu Gln Ser Thr
    1890                1895                1900                
 Ala Glu Leu Thr Ser His Leu Asn Ile His Asn Glu Glu Phe Gln Lys
1905                1910                1915                1920
 Arg Ala Lys Arg Gln Glu Arg Arg Lys Gln Leu Leu Ser Lys Gln Lys
                1925                1930                1935    
 Tyr Ala Asp Gly Ala Phe Ala Asp Phe Lys Gln Glu Arg Pro Phe Gly
            1940                1945                1950        
 His Leu Glu Glu Val Pro Lys Ile Lys Glu Arg Lys Val Val Gly Tyr
        1955                1960                1965            
 Lys Cys Lys Phe Cys Val Glu Val His Pro Thr Leu Arg Ala Ile Cys
    1970                1975                1980                
 Asn His Leu Arg Lys His Val Gln Tyr Gly Asn Val Pro Ala Val Ser
1985                1990                1995                2000
 Ala Ala Val Lys Glu Ala Asp Asp Pro Ala His Leu Phe Leu Asp Gly
                2005                2010                2015    
 Leu Glu Ala Ala Lys Asp Ala Ser Gly Ala Leu Val Gly Arg Val Asp
            2020                2025                2030        
 Gly Glu His Cys Leu Leu Asp Gly Met Leu Glu Asp Glu Thr Arg Pro
        2035                2040                2045            
 Gly Gly Tyr His Cys Ser Gln Cys Asp Arg Val Leu Met Ser Met Gln
    2050                2055                2060                
 Gly Leu Arg Ser His Glu Arg Ser His Leu Ala Leu Ala Met Phe Thr
2065                2070                2075                2080
 Arg Glu Asp Lys Tyr Ser Cys Gln Tyr Cys Ser Phe Val Ser Ala Phe
                2085                2090                2095    
 Arg His Asn Leu Asp Arg His Met Gln Thr His His Gly His His Lys
            2100                2105                2110        
 Pro Phe Arg Cys Lys Leu Cys Ser Phe Lys Ser Ser Tyr Asn Ser Arg
        2115                2120                2125            
 Leu Lys Thr His Ile Leu Lys Ala His Ala Gly Glu His Ala Tyr Lys
    2130                2135                2140                
 Cys Ser Trp Cys Ser Phe Ser Thr Met Thr Ile Ser Gln Leu Lys Glu
2145                2150                2155                2160
 His Ser Leu Lys Val His Gly Lys Ala Leu Thr Leu Pro Arg Pro Arg
                2165                2170                2175    
 Ile Val Ser Leu Leu Ser Ser His Ser His His Ser Ser Gln Lys Ala
            2180                2185                2190        
 Thr Pro Ala Glu Glu Val Glu Asp Ser Asn Asp Ser Ser Tyr Ser Glu
        2195                2200                2205            
 Pro Pro Asp Val Gln Gln Gln Leu Asn His Tyr Gln Ser Ala Ala Leu
    2210                2215                2220                
 Ala Arg Asn Asn Ser Arg Val Ser Pro Val Pro Leu Ser Gly Ala Ala
2225                2230                2235                2240
 Ala Gly Thr Glu Gln Lys Thr Glu Ala Val Leu His Cys Glu Phe Cys
                2245                2250                2255    
 Glu Phe Ser Ser Gly Tyr Ile Gln Ser Ile Arg Arg His Tyr Arg Asp
            2260                2265                2270        
 Lys His Gly Gly Lys Lys Leu Phe Lys Cys Lys Asp Cys Ser Phe Tyr
        2275                2280                2285            
 Thr Gly Phe Lys Ser Ala Phe Thr Met His Val Glu Ala Gly His Ser
    2290                2295                2300                
 Ala Val Pro Glu Glu Gly Pro Lys Asp Leu Arg Cys Pro Leu Cys Leu
2305                2310                2315                2320
 Tyr His Thr Lys Tyr Lys Arg Asn Met Ile Asp His Ile Val Leu His
                2325                2330                2335    
 Arg Glu Glu Arg Val Val Pro Ile Glu Val Cys Arg Ser Lys Leu Ser
            2340                2345                2350        
 Lys Tyr Leu Gln Gly Val Val Phe Arg Cys Asp Lys Cys Thr Phe Thr
        2355                2360                2365            
 Cys Ser Ser Asp Glu Ser Leu Gln Gln His Ile Glu Lys His Asn Glu
    2370                2375                2380                
 Leu Lys Pro Tyr Lys Cys Gln Leu Cys Tyr Tyr Glu Thr Lys His Thr
2385                2390                2395                2400
 Glu Glu Leu Asp Ser His Leu Arg Asp Glu His Lys Val Ser Arg Asn
                2405                2410                2415    
 Phe Glu Leu Val Gly Arg Val Asn Leu Asp Gln Leu Glu Gln Met Lys
            2420                2425                2430        
 Glu Lys Met Glu Ser Ser Ser Ser Asp Asp Glu Asp Lys Glu Glu Glu
        2435                2440                2445            
 Met Asn Ser Lys Ala Glu Asp Arg Glu Leu Met Arg Phe Ser Asp His
    2450                2455                2460                
 Gly Ala Ala Leu Asn Thr Glu Lys Arg Phe Pro Cys Glu Phe Cys Gly
2465                2470                2475                2480
 Arg Ala Phe Ser Gln Gly Ser Glu Trp Glu Arg His Val Leu Arg His
                2485                2490                2495    
 Gly Met Ala Leu Asn Asp Thr Lys Gln Val Ser Arg Glu Glu Ile His
            2500                2505                2510        
 Pro Lys Glu Ile Met Glu Asn Ser Val Lys Met Pro Ser Ile Glu Glu
        2515                2520                2525            
 Lys Glu Asp Asp Glu Ala Ile Gly Ile Asp Phe Ser Leu Lys Asn Glu
    2530                2535                2540                
 Thr Val Ala Ile Cys Val Val Thr Ala Asp Lys Ser Leu Leu Glu Asn
2545                2550                2555                2560
 Ala Glu Ala Lys Lys Glu
                2565    



      <210> 978
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 978
 Met Pro Leu Leu Glu Tyr Ala Arg Asn Met Leu Arg Thr Trp Ser Ser
   1               5                  10                  15    
 Leu Pro Trp Thr Arg Phe Arg Val Cys Leu Leu Ser Leu Ser Leu Phe
              20                  25                  30        
 Leu Trp Ala Asn Arg Leu Glu Asp Ser Arg Ser Cys Gln Pro Asn Pro
          35                  40                  45            
 Met Ser Leu Thr Thr Leu Pro Gly His Arg Leu Lys Glu Ala Val Trp
      50                  55                  60                
 Leu Pro Ala Pro Ser Arg Thr Met Ser Pro His Leu Asp Pro Asn Gln
  65                  70                  75                  80
 Leu Gly Ile Leu Leu Lys Val Leu Arg Lys Glu Lys Glu Asp Gly Asp
                  85                  90                  95    
 Tyr Pro Asp Met Met Ala Thr His Pro Ser Ser Arg Tyr Glu Ala Cys
             100                 105                 110        
 Ser Ser Gly Ile Thr Leu Gly Met Phe Thr Leu Phe Phe His His Phe
         115                 120                 125            
 Asn Lys Tyr Val
     130        



      <210> 979
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 979
 Met Pro Leu Leu Glu Tyr Ala Arg Asn Met Leu Arg Thr Trp Ser Ser
   1               5                  10                  15    
 Leu Pro Trp Thr Arg Phe Arg Val Cys Leu Leu Ser Leu Ser Leu Phe
              20                  25                  30        
 Leu Trp Ala Asn Arg Leu Glu Asp Ser Arg Ser Cys Gln Pro Asn Pro
          35                  40                  45            
 Met Ser Leu Thr Thr Leu Pro Gly His Arg Leu Lys Glu Ala Val Trp
      50                  55                  60                
 Leu Pro Ala Pro Ser Arg Ile Ile Thr Ser
  65                  70                



      <210> 980
      <211> 442
      <212> PRT
      <213> Homo sapiens


      <400> 980
 Met Gln Ile Pro Arg Ala Ala Leu Leu Pro Leu Leu Leu Leu Leu Leu
   1               5                  10                  15    
 Ala Ala Pro Ala Arg Asp Ala Cys Gly Cys Cys Glu Val Cys Gly Ala
              20                  25                  30        
 Pro Glu Gly Ala Ala Cys Gly Leu Gln Glu Gly Pro Cys Gly Glu Gly
          35                  40                  45            
 Leu Gln Cys Val Val Pro Phe Gly Val Pro Ala Ser Ala Thr Val Arg
      50                  55                  60                
 Arg Arg Ala Gln Ala Gly Leu Cys Val Cys Ala Ser Ser Glu Pro Val
  65                  70                  75                  80
 Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn Leu Cys Gln Leu Arg Ala
                  85                  90                  95    
 Ala Ser Arg Arg Ser Glu Arg Leu His Arg Pro Pro Val Ile Val Leu
             100                 105                 110        
 Gln Arg Gly Ala Cys Gly Gln Gly Gln Glu Asp Pro Asn Ser Leu Arg
         115                 120                 125            
 His Lys Tyr Asn Phe Ile Ala Asp Val Val Glu Lys Ile Ala Pro Ala
     130                 135                 140                
 Val Val His Ile Glu Leu Phe Arg Lys Leu Pro Phe Ser Lys Arg Glu
 145                 150                 155                 160
 Val Pro Val Ala Ser Gly Ser Gly Phe Ile Val Ser Glu Asp Gly Leu
                 165                 170                 175    
 Ile Val Thr Asn Ala His Val Val Thr Asn Lys His Arg Val Lys Val
             180                 185                 190        
 Glu Leu Lys Asn Gly Ala Thr Tyr Glu Ala Lys Ile Lys Asp Val Asp
         195                 200                 205            
 Glu Lys Ala Asp Ile Ala Leu Ile Lys Ile Asp His Gln Gly Lys Leu
     210                 215                 220                
 Pro Val Leu Leu Leu Gly Arg Ser Ser Glu Leu Arg Pro Gly Glu Phe
 225                 230                 235                 240
 Val Val Ala Ile Gly Ser Pro Phe Ser Leu Gln Asn Thr Val Thr Thr
                 245                 250                 255    
 Gly Ile Val Ser Thr Thr Gln Arg Gly Gly Lys Glu Leu Gly Leu Arg
             260                 265                 270        
 Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp Ala Ile Ile Asn Tyr Gly
         275                 280                 285            
 Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Ile
     290                 295                 300                
 Asn Thr Leu Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp
 305                 310                 315                 320
 Lys Ile Lys Lys Phe Leu Thr Glu Ser His Asp Arg Gln Ala Lys Gly
                 325                 330                 335    
 Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly Ile Arg Met Met Ser Leu
             340                 345                 350        
 Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp Arg His Arg Asp Phe Pro
         355                 360                 365            
 Asp Val Ile Ser Gly Ala Tyr Ile Ile Glu Val Ile Pro Asp Thr Pro
     370                 375                 380                
 Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp Val Ile Ile Ser Ile Asn
 385                 390                 395                 400
 Gly Gln Ser Val Val Ser Ala Asn Asp Val Ser Asp Val Ile Lys Arg
                 405                 410                 415    
 Glu Ser Thr Leu Asn Met Val Val Arg Arg Gly Asn Glu Asp Ile Met
             420                 425                 430        
 Ile Thr Val Ile Pro Glu Glu Ile Asp Pro
         435                 440        



      <210> 981
      <211> 422
      <212> PRT
      <213> Homo sapiens


      <400> 981
 Met Arg Gly Leu Val Val Phe Leu Ala Val Phe Ala Leu Ser Glu Val
   1               5                  10                  15    
 Asn Ala Ile Thr Arg Val Pro Leu His Lys Gly Lys Ser Leu Arg Arg
              20                  25                  30        
 Ala Leu Lys Glu Arg Arg Leu Leu Glu Asp Phe Leu Arg Asn His His
          35                  40                  45            
 Tyr Ala Val Ser Arg Lys His Ser Ser Ser Gly Val Val Ala Ser Glu
      50                  55                  60                
 Ser Leu Thr Asn Tyr Leu Asp Cys Gln Tyr Phe Gly Lys Ile Tyr Ile
  65                  70                  75                  80
 Gly Thr Leu Pro Gln Lys Phe Thr Leu Val Phe Asp Thr Gly Ser Pro
                  85                  90                  95    
 Asp Ile Trp Val Pro Ser Val Tyr Cys Asn Ser Asp Ala Cys Gln Arg
             100                 105                 110        
 Ile Ala Ser Ile Glu Ala Ile Phe Leu Gln Gly Leu Leu Arg Gly Ser
         115                 120                 125            
 Ala Leu Ala Gly Thr Val Ser Gly Glu Lys Ile Leu Arg Ala Pro Leu
     130                 135                 140                
 Thr Leu Gly Leu Cys Phe Arg Lys Pro Pro Thr Leu Arg Ser Val Gln
 145                 150                 155                 160
 Val Leu His Pro Gln Asn Met Gly Lys Ser Leu Ser Ile Gln Tyr Gly
                 165                 170                 175    
 Thr Gly Ser Met Arg Gly Leu Leu Gly Tyr Asp Thr Val Thr Asp Leu
             180                 185                 190        
 Val Glu Val Met Ile Leu Leu Gln Val Ser Asn Ile Val Asp Pro His
         195                 200                 205            
 Gln Thr Val Gly Leu Ser Thr Gln Glu Pro Gly Asp Val Phe Thr Tyr
     210                 215                 220                
 Ser Glu Phe Asp Gly Ile Leu Gly Leu Ala Tyr Pro Ser Leu Ala Ser
 225                 230                 235                 240
 Glu Asn Asp Gln Gly Ser Met Leu Thr Leu Arg Ala Ile Asp Leu Ser
                 245                 250                 255    
 Tyr Tyr Thr Gly Ser Leu His Trp Ile Pro Met Thr Ala Arg Ile Leu
             260                 265                 270        
 Ala Val His Cys Gly Gln Glu Gly Pro Gly Glu Gly Gly Leu Asp Glu
         275                 280                 285            
 Ala Ile Leu His Thr Phe Gly Ser Val Ile Ile Asp Gly Val Val Val
     290                 295                 300                
 Ala Cys Asp Gly Gly Cys Gln Ala Ile Leu Asp Thr Gly Thr Ser Leu
 305                 310                 315                 320
 Leu Val Gly Pro Gly Gly Asn Ile Leu Asn Ile Gln Gln Ala Ile Gly
                 325                 330                 335    
 Ala Thr Ala Gly Gln Tyr Asn Glu Phe Asp Ile Asp Cys Gly Arg Leu
             340                 345                 350        
 Ser Ser Ile Pro Thr Ala Val Phe Glu Ile His Gly Lys Lys Tyr Pro
         355                 360                 365            
 Leu Pro Pro Ser Ala Tyr Thr Ser Gln Asp Gln Gly Phe Cys Thr Ser
     370                 375                 380                
 Gly Phe Gln Gly Asp Tyr Ser Ser Gln Gln Trp Ile Leu Gly Asn Val
 385                 390                 395                 400
 Phe Ile Trp Glu Tyr Tyr Ser Val Phe Asp Arg Thr Asn Asn Arg Val
                 405                 410                 415    
 Gly Leu Ala Lys Ala Val
             420        



      <210> 982
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 982
 Met Gly Pro Pro Ser Leu Val Leu Cys Leu Leu Ser Ala Thr Val Phe
   1               5                  10                  15    
 Ser Leu Leu Gly Gly Ser Ser Ala Phe Leu Ser His His Arg Leu Lys
              20                  25                  30        
 Gly Arg Phe Gln Arg Asp Arg Arg Asn Ile Arg Pro Asn Ile Ile Leu
          35                  40                  45            
 Val Leu Thr Asp Asp Gln Asp Val Glu Leu Ala Phe Phe Gly Lys Tyr
      50                  55                  60                
 Leu Asn Glu Tyr Asn Gly Ser Tyr Val Pro Pro Gly Trp Lys Glu Trp
  65                  70                  75                  80
 Val Gly Leu Leu Lys Asn Ser Arg Phe Tyr Asn Tyr Thr Leu Cys Arg
                  85                  90                  95    
 Asn Gly Val Lys Glu Lys His Gly Ser Asp Tyr Ser Lys His Ala Glu
             100                 105                 110        
 Leu Gln Leu Arg Ala Gln Pro Gly Gln Thr Leu Asp His Ala Leu His
         115                 120                 125            
 Gly Ala His Glu Ala His Pro His Gly Ile His Gln His Ala Pro Ala
     130                 135                 140                
 Glu Ala Leu Ala Asp Pro His Val Gly Gly Arg Leu His Gly Asp Asp
 145                 150                 155                 160
 Leu Gln His Ala Gly
                 165



      <210> 983
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 983
 Met Gln Arg Pro Phe Leu Ser Val Pro Cys Leu Leu Leu Leu Pro Ala
   1               5                  10                  15    
 Arg Val Val Trp Gly Cys Trp Cys Phe Leu Pro Gly Glu Asp Gly Gly
              20                  25                  30        
 Gly Cys Pro Thr Pro Ser Ser Gly Arg Ile Lys Leu Leu Gln Gln Cys
          35                  40                  45            
 Leu Leu His Pro Ser Leu Arg Ser Ile Thr Val Ser Arg Arg Ser Ala
      50                  55                  60                
 Gln Leu Leu Cys Arg Leu Lys Leu Gln Asn His Ile Pro Lys Val Pro
  65                  70                  75                  80
 Gly Lys Asn Val
                



      <210> 984
      <211> 374
      <212> PRT
      <213> Homo sapiens


      <400> 984
 Met Lys Pro Leu Leu Glu Thr Leu Tyr Leu Leu Gly Met Leu Val Pro
   1               5                  10                  15    
 Gly Gly Leu Gly Tyr Asp Arg Ser Leu Ala Gln His Arg Gln Glu Ile
              20                  25                  30        
 Val Asp Lys Ser Val Ser Pro Trp Ser Leu Glu Thr Tyr Ser Tyr Asn
          35                  40                  45            
 Ile Tyr His Pro Met Gly Glu Ile Tyr Glu Trp Met Arg Glu Ile Ser
      50                  55                  60                
 Glu Lys Tyr Lys Glu Val Val Thr Gln His Phe Leu Gly Val Thr Tyr
  65                  70                  75                  80
 Glu Thr His Pro Ile Tyr Tyr Leu Lys Ile Ser Gln Pro Ser Gly Asn
                  85                  90                  95    
 Pro Lys Lys Ile Ile Trp Met Asp Cys Gly Ile His Ala Arg Glu Trp
             100                 105                 110        
 Ile Ala Pro Ala Phe Cys Gln Trp Phe Val Lys Glu Ile Leu Gln Asn
         115                 120                 125            
 His Lys Asp Asn Ser Arg Ile Arg Lys Leu Leu Arg Asn Leu Asp Phe
     130                 135                 140                
 Tyr Val Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile Tyr Thr Trp Thr
 145                 150                 155                 160
 Thr Asp Arg Leu Trp Arg Lys Ser Arg Ser Pro His Asn Asn Gly Thr
                 165                 170                 175    
 Cys Phe Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala Ser Trp Cys Ser
             180                 185                 190        
 Ile Gly Ala Ser Arg Asn Cys Gln Asp Gln Thr Phe Cys Gly Thr Gly
         195                 200                 205            
 Pro Val Ser Glu Pro Glu Thr Lys Ala Val Ala Ser Phe Ile Glu Ser
     210                 215                 220                
 Lys Lys Asp Asp Ile Leu Cys Phe Leu Thr Met His Ser Tyr Gly Gln
 225                 230                 235                 240
 Leu Ile Leu Thr Pro Tyr Gly Tyr Thr Lys Asn Lys Ser Ser Asn His
                 245                 250                 255    
 Pro Glu Met Ile Gln Val Gly Gln Lys Ala Ala Asn Ala Leu Lys Ala
             260                 265                 270        
 Lys Tyr Gly Thr Asn Tyr Arg Val Gly Ser Ser Ala Asp Ile Leu Tyr
         275                 280                 285            
 Ala Ser Ser Gly Ser Ser Arg Asp Trp Ala Arg Asp Ile Gly Ile Pro
     290                 295                 300                
 Phe Ser Tyr Thr Phe Glu Leu Arg Asp Ser Gly Thr Tyr Gly Phe Val
 305                 310                 315                 320
 Leu Pro Glu Ala Gln Ile Gln Pro Thr Cys Glu Glu Thr Met Glu Ala
                 325                 330                 335    
 Val Leu Ser Val Leu Asp Asp Val Tyr Ala Lys His Trp His Ser Asp
             340                 345                 350        
 Ser Ala Gly Arg Val Thr Ser Ala Thr Met Leu Leu Gly Leu Leu Val
         355                 360                 365            
 Ser Cys Met Ser Leu Leu
     370                



      <210> 985
      <211> 374
      <212> PRT
      <213> Homo sapiens


      <400> 985
 Met Lys Pro Leu Leu Glu Thr Leu Tyr Leu Leu Gly Met Leu Val Pro
   1               5                  10                  15    
 Gly Gly Leu Gly Tyr Asp Arg Ser Leu Ala Gln His Arg Gln Glu Ile
              20                  25                  30        
 Val Asp Lys Ser Val Ser Pro Trp Ser Leu Glu Thr Tyr Ser Tyr Asn
          35                  40                  45            
 Ile Tyr His Pro Met Gly Glu Ile Tyr Glu Trp Met Arg Glu Ile Ser
      50                  55                  60                
 Glu Lys Tyr Lys Glu Val Val Thr Gln His Phe Leu Gly Val Thr Tyr
  65                  70                  75                  80
 Glu Thr His Pro Ile Tyr Tyr Leu Lys Ile Ser Gln Pro Ser Gly Asn
                  85                  90                  95    
 Pro Lys Lys Ile Ile Trp Met Asp Cys Gly Ile His Ala Arg Glu Trp
             100                 105                 110        
 Ile Ala Pro Ala Phe Cys Gln Trp Phe Val Lys Glu Ile Leu Gln Asn
         115                 120                 125            
 His Lys Asp Asn Ser Arg Ile Arg Lys Leu Leu Arg Asn Leu Asp Phe
     130                 135                 140                
 Tyr Val Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile Tyr Thr Trp Thr
 145                 150                 155                 160
 Thr Asp Arg Leu Trp Arg Lys Ser Arg Ser Pro His Asn Asn Gly Thr
                 165                 170                 175    
 Cys Phe Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala Ser Trp Cys Ser
             180                 185                 190        
 Ile Gly Ala Ser Arg Asn Cys Gln Asp Gln Thr Phe Cys Gly Thr Gly
         195                 200                 205            
 Pro Val Ser Glu Pro Glu Thr Lys Ala Val Ala Ser Phe Ile Glu Ser
     210                 215                 220                
 Lys Lys Asp Asp Ile Leu Cys Phe Leu Thr Met His Ser Tyr Gly Gln
 225                 230                 235                 240
 Leu Ile Leu Thr Pro Tyr Gly Tyr Thr Lys Asn Lys Ser Ser Asn His
                 245                 250                 255    
 Pro Glu Met Ile Gln Val Gly Gln Lys Ala Ala Asn Ala Leu Lys Ala
             260                 265                 270        
 Lys Tyr Gly Thr Asn Tyr Arg Val Gly Ser Ser Ala Asp Ile Leu Tyr
         275                 280                 285            
 Ala Ser Ser Gly Ser Ser Arg Asp Trp Ala Arg Asp Ile Gly Ile Pro
     290                 295                 300                
 Phe Ser Tyr Thr Phe Glu Leu Arg Asp Ser Gly Thr Tyr Gly Phe Val
 305                 310                 315                 320
 Leu Pro Glu Ala Gln Ile Gln Pro Thr Cys Glu Glu Thr Met Glu Ala
                 325                 330                 335    
 Val Leu Ser Val Leu Asp Asp Val Tyr Ala Lys His Trp His Ser Asp
             340                 345                 350        
 Ser Ala Gly Arg Val Thr Ser Ala Thr Met Leu Leu Gly Leu Leu Val
         355                 360                 365            
 Ser Cys Met Ser Leu Leu
     370                



      <210> 986
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 986
 Met Ala Ala Ala Gly Ala Gly Arg Leu Arg Arg Val Ala Ser Ala Leu
   1               5                  10                  15    
 Leu Leu Arg Ser Pro Arg Leu Pro Ala Arg Glu Leu Ser Ala Pro Ala
              20                  25                  30        
 Arg Leu Tyr His Lys Lys Val Val Asp His Tyr Glu Asn Pro Arg Asn
          35                  40                  45            
 Val Gly Ser Leu Asp Lys Thr Ser Lys Asn Val Gly Thr Gly Leu Val
      50                  55                  60                
 Gly Ala Pro Ala Cys Gly Asp Val Met Lys Leu Gln Ile Gln Val Asp
  65                  70                  75                  80
 Glu Lys Gly Lys Ile Val Asp Ala Arg Phe Lys Thr Phe Gly Cys Gly
                  85                  90                  95    
 Ser Ala Ile Ala Ser Ser Ser Leu Ala Thr Glu Trp Val Lys Gly Lys
             100                 105                 110        
 Thr Val Glu Glu Ala Leu Thr Ile Lys Asn Thr Asp Ile Ala Lys Glu
         115                 120                 125            
 Leu Cys Leu Pro Pro Val Lys Leu His Cys Ser Met Leu Ala Glu Asp
     130                 135                 140                
 Ala Ile Lys Ala Ala Leu Ala Asp Tyr Lys Leu Lys Gln Glu Pro Lys
 145                 150                 155                 160
 Lys Gly Glu Ala Glu Lys Lys
                 165        



      <210> 987
      <211> 289
      <212> PRT
      <213> Homo sapiens


      <400> 987
 Met Leu Leu Trp Phe Ser Asn Lys Pro Asn Met His Leu His His Val
   1               5                  10                  15    
 Gly Asn Lys His Phe Phe Cys Cys Val Asn Asn Val Ile Phe Ile Val
              20                  25                  30        
 Val Cys Leu Cys Phe Asp Cys Asp Leu Ser His Glu Val Gly Cys Gly
          35                  40                  45            
 Ile Phe His Leu Trp His Arg Val Gly Ala Gln Lys Val Leu Asp Phe
      50                  55                  60                
 Gly Pro Phe Arg Ile Ser Asp Phe Trp Ile Arg Asn Ser Gln Pro Val
  65                  70                  75                  80
 Leu Ser Ala Arg Arg Leu Ala Arg Arg Ala Leu Phe Gly Ala Gly Gly
                  85                  90                  95    
 Gly Lys Ala Gly Lys Gly Gly Leu Thr Leu Gln Glu Ala Ile Gln Arg
             100                 105                 110        
 Leu Arg Asp Thr Glu Glu Met Leu Ser Lys Lys Gln Glu Phe Leu Glu
         115                 120                 125            
 Lys Lys Ile Glu Gln Arg His Gly Thr Lys Asn Lys Pro Ala Ala Leu
     130                 135                 140                
 Gln Ala Leu Lys Arg Lys Lys Arg Tyr Glu Lys Gln Leu Ala Gln Ile
 145                 150                 155                 160
 Asp Gly Thr Leu Ser Thr Ile Glu Phe Gln Gln Gln Ala Leu Glu Asn
                 165                 170                 175    
 Ala Asn Thr Asn Thr Glu Val Leu Lys Asn Met Gly Ser Ala Ala Lys
             180                 185                 190        
 Ala Lys Lys Ala Ala His Asp Asn Met Asp Ile Asp Lys Val Asp Glu
         195                 200                 205            
 Leu Met Gln Asp Ile Ala Asp Gln Gln Glu Leu Gly Glu Glu Ile Ser
     210                 215                 220                
 Thr Ala Ile Ser Lys Pro Val Gly Phe Gly Glu Lys Ser Asp Glu Asp
 225                 230                 235                 240
 Glu Leu Met Ala Glu Leu Glu Glu Leu Glu Gln Glu Glu Pro Asp Lys
                 245                 250                 255    
 Asn Leu Leu Glu Val Ser Gly Pro Glu Thr Val Pro Leu Pro Asn Val
             260                 265                 270        
 Pro Ser Ile Ala Leu Pro Ser Lys Pro Ala Lys Lys Arg Lys Thr Thr
         275                 280                 285            
 Thr
    



      <210> 988
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 988
 Met Glu Arg Leu Val Leu Thr Leu Cys Thr Leu Pro Leu Ala Val Ala
   1               5                  10                  15    
 Ser Ala Gly Cys Ala Thr Thr Pro Ala Arg Asn Leu Ser Cys Tyr Gln
              20                  25                  30        
 Cys Phe Lys Val Ser Ser Trp Thr Glu Cys Pro Pro Thr Trp Cys Ser
          35                  40                  45            
 Pro Leu Asp Gln Val Cys Ile Ser Asn Glu Val Val Val Ser Phe Lys
      50                  55                  60                
 Trp Ser Val Arg Val Leu Leu Ser Lys Arg Cys Ala Pro Arg Cys Pro
  65                  70                  75                  80
 Asn Asp Asn Met Lys Phe Glu Trp Ser Pro Ala Pro Met Val Gln Gly
                  85                  90                  95    
 Val Ile Thr Arg Arg Cys Cys Ser Trp Ala Leu Cys Asn Arg Ala Leu
             100                 105                 110        
 Thr Pro Gln Glu Gly Arg Trp Ala Leu Arg Gly Gly Leu Leu Leu Gln
         115                 120                 125            
 Asp Pro Ser Arg Gly Arg Arg Thr Trp Val Arg Pro Gln Leu Gly Leu
     130                 135                 140                
 Pro Leu Cys Leu Pro Ile Ser Ser Pro Leu Cys Pro Arg Glu Thr Gln
 145                 150                 155                 160
 Glu Gly
        



      <210> 989
      <211> 333
      <212> PRT
      <213> Homo sapiens


      <400> 989
 Met Glu Asp Leu Glu Glu Asp Val Arg Phe Ile Val Asp Glu Thr Leu
   1               5                  10                  15    
 Asp Phe Gly Gly Leu Ser Pro Ser Asp Ser Arg Glu Glu Glu Asp Ile
              20                  25                  30        
 Thr Val Leu Val Thr Pro Glu Lys Pro Leu Arg Arg Cys Leu Ser His
          35                  40                  45            
 Arg Ser Asp Pro Asn Ala Val Ala Pro Ala Pro Gln Gly Val Arg Leu
      50                  55                  60                
 Ser Leu Cys Pro Leu Ser Pro Glu Lys Leu Glu Glu Ile Leu Asp Glu
  65                  70                  75                  80
 Ala Asn Arg Leu Ala Ala Gln Leu Glu Gln Cys Ala Leu Gln Asp Arg
                  85                  90                  95    
 Glu Ser Ala Gly Glu Gly Leu Gly Pro Arg Arg Val Lys Pro Ser Pro
             100                 105                 110        
 Arg Arg Glu Thr Phe Val Leu Glu Asp Ser Pro Val Arg Asp Leu Leu
         115                 120                 125            
 Pro Thr Val Asn Ser Leu Thr Arg Ser Thr Pro Ser Pro Ser Ser Leu
     130                 135                 140                
 Thr Pro Arg Leu Arg Ser Asn Asp Arg Lys Gly Ser Val Arg Ala Leu
 145                 150                 155                 160
 Arg Ala Thr Ser Gly Lys Arg Pro Ser Asn Met Lys Arg Glu Ser Pro
                 165                 170                 175    
 Thr Cys Asn Leu Phe Pro Ala Ser Lys Ser Pro Ala Ser Ser Pro Leu
             180                 185                 190        
 Thr Arg Ser Thr Pro Pro Val Arg Gly Arg Ala Gly Pro Ser Gly Arg
         195                 200                 205            
 Ala Ala Ala Ser Pro Pro Thr Pro Ile Arg Ser Val Leu Ala Pro Gln
     210                 215                 220                
 Pro Ser Thr Ser Asn Ser Gln Arg Leu Pro Arg Pro Gln Gly Ala Ala
 225                 230                 235                 240
 Ala Lys Ser Ser Ser Gln Leu Pro Ile Pro Ser Ala Ile Pro Arg Pro
                 245                 250                 255    
 Ala Ser Arg Met Pro Leu Thr Ser Arg Ser Val Pro Pro Gly Arg Gly
             260                 265                 270        
 Ala Leu Pro Pro Asp Ser Leu Ser Thr Arg Lys Gly Leu Pro Arg Pro
         275                 280                 285            
 Ser Thr Ala Gly His Arg Val Arg Glu Ser Gly His Lys Val Pro Val
     290                 295                 300                
 Ser Gln Arg Leu Asn Leu Pro Val Met Gly Ala Thr Arg Ser Asn Leu
 305                 310                 315                 320
 Gln Pro Pro Arg Lys Val Ala Val Pro Gly Pro Thr Arg
                 325                 330            



      <210> 990
      <211> 297
      <212> PRT
      <213> Homo sapiens


      <400> 990
 Met Ser Ser Asp Gly Glu Pro Leu Ser Arg Met Asp Ser Glu Asp Ser
   1               5                  10                  15    
 Ile Ser Ser Thr Ile Met Asp Val Asp Ser Thr Ile Ser Ser Gly Arg
              20                  25                  30        
 Ser Thr Pro Ala Met Met Asn Gly Gln Gly Ser Thr Thr Ser Ser Ser
          35                  40                  45            
 Lys Asn Ile Ala Tyr Asn Cys Cys Trp Asp Gln Cys Gln Ala Cys Phe
      50                  55                  60                
 Asn Ser Ser Pro Asp Leu Ala Asp His Ile Arg Ser Ile His Val Asp
  65                  70                  75                  80
 Gly Gln Arg Gly Gly Val Phe Val Cys Leu Trp Lys Gly Cys Lys Val
                  85                  90                  95    
 Tyr Asn Thr Pro Ser Thr Ser Gln Ser Trp Leu Gln Arg His Met Leu
             100                 105                 110        
 Thr His Ser Gly Asp Lys Pro Phe Lys Cys Val Val Gly Gly Cys Asn
         115                 120                 125            
 Ala Ser Phe Ala Ser Gln Gly Gly Leu Ala Arg His Val Pro Thr His
     130                 135                 140                
 Phe Ser Gln Gln Asn Ser Ser Lys Val Ser Ser Gln Pro Lys Ala Lys
 145                 150                 155                 160
 Glu Glu Ser Pro Ser Lys Ala Gly Met Asn Lys Arg Arg Lys Leu Lys
                 165                 170                 175    
 Asn Lys Arg Arg Arg Ser Leu Pro Arg Pro His Asp Phe Phe Asp Ala
             180                 185                 190        
 Gln Thr Leu Asp Ala Ile Arg His Arg Ala Ile Cys Phe Asn Leu Ser
         195                 200                 205            
 Ala His Ile Glu Ser Leu Gly Lys Gly His Ser Val Val Phe His Ser
     210                 215                 220                
 Thr Val Ile Ala Lys Arg Lys Glu Asp Ser Gly Lys Ile Lys Leu Leu
 225                 230                 235                 240
 Leu His Trp Met Pro Glu Asp Ile Leu Pro Asp Val Trp Val Asn Glu
                 245                 250                 255    
 Ser Glu Arg His Gln Leu Lys Thr Lys Val Val His Leu Ser Lys Leu
             260                 265                 270        
 Pro Lys Asp Thr Ala Leu Leu Leu Asp Pro Asn Ile Tyr Arg Thr Met
         275                 280                 285            
 Pro Gln Lys Arg Leu Lys Arg Arg His
     290                 295        



      <210> 991
      <211> 558
      <212> PRT
      <213> Homo sapiens


      <400> 991
 Met Ala Glu Lys Gly Asp Cys Ile Ala Ser Val Tyr Gly Tyr Asp Leu
   1               5                  10                  15    
 Gly Gly Arg Phe Val Asp Phe Gln Pro Leu Gly Phe Gly Val Asn Gly
              20                  25                  30        
 Leu Val Leu Ser Ala Val Asp Ser Arg Ala Cys Arg Lys Val Ala Val
          35                  40                  45            
 Lys Lys Ile Ala Leu Ser Asp Ala Arg Ser Met Lys His Ala Leu Arg
      50                  55                  60                
 Glu Ile Lys Ile Ile Arg Arg Leu Asp His Asp Asn Ile Val Lys Val
  65                  70                  75                  80
 Tyr Glu Val Leu Gly Pro Lys Gly Thr Asp Leu Gln Gly Glu Leu Phe
                  85                  90                  95    
 Lys Phe Ser Val Ala Tyr Ile Val Gln Glu Tyr Met Glu Thr Asp Leu
             100                 105                 110        
 Ala Arg Leu Leu Glu Gln Gly Thr Leu Ala Glu Glu His Ala Lys Leu
         115                 120                 125            
 Phe Met Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn
     130                 135                 140                
 Val Leu His Arg Asp Leu Lys Pro Ala Asn Ile Phe Ile Ser Thr Glu
 145                 150                 155                 160
 Asp Leu Val Leu Lys Ile Gly Asp Phe Gly Leu Ala Arg Ile Val Asp
                 165                 170                 175    
 Gln His Tyr Ser His Lys Gly Tyr Leu Ser Glu Gly Leu Val Thr Lys
             180                 185                 190        
 Trp Tyr Arg Ser Pro Arg Leu Leu Leu Ser Pro Asn Asn Tyr Thr Lys
         195                 200                 205            
 Ala Ile Asp Met Trp Ala Ala Gly Cys Ile Leu Ala Glu Met Leu Thr
     210                 215                 220                
 Gly Arg Met Leu Phe Ala Gly Ala His Glu Leu Glu Gln Met Gln Leu
 225                 230                 235                 240
 Ile Leu Glu Thr Ile Pro Val Ile Arg Glu Glu Asp Lys Asp Glu Leu
                 245                 250                 255    
 Leu Arg Val Met Pro Ser Phe Val Ser Ser Thr Trp Glu Val Lys Arg
             260                 265                 270        
 Pro Leu Arg Lys Leu Leu Pro Glu Val Asn Ser Glu Ala Ile Asp Phe
         275                 280                 285            
 Leu Glu Lys Ile Leu Thr Phe Asn Pro Met Asp Arg Leu Thr Ala Glu
     290                 295                 300                
 Met Gly Leu Gln His Pro Tyr Met Ser Pro Tyr Ser Cys Pro Glu Asp
 305                 310                 315                 320
 Glu Pro Thr Ser Gln His Pro Phe Arg Ile Glu Asp Glu Ile Asp Asp
                 325                 330                 335    
 Ile Val Leu Met Ala Ala Asn Gln Ser Gln Leu Ser Asn Trp Asp Thr
             340                 345                 350        
 Cys Ser Ser Arg Tyr Pro Val Ser Leu Ser Ser Asp Leu Glu Trp Arg
         355                 360                 365            
 Pro Asp Arg Cys Gln Asp Ala Ser Glu Val Gln Arg Asp Pro Arg Ala
     370                 375                 380                
 Gly Ser Ala Pro Leu Ala Glu Asn Val Gln Val Asp Pro Arg Lys Asp
 385                 390                 395                 400
 Ser His Ser Ser Ser Glu Arg Phe Leu Glu Gln Ser His Ser Ser Met
                 405                 410                 415    
 Glu Arg Ala Phe Glu Ala Asp Tyr Gly Arg Ser Cys Asp Tyr Lys Val
             420                 425                 430        
 Gly Ser Pro Ser Tyr Leu Asp Lys Leu Leu Trp Arg Asp Asn Lys Pro
         435                 440                 445            
 His His Tyr Ser Glu Pro Lys Leu Ile Leu Asp Leu Ser His Trp Lys
     450                 455                 460                
 Gln Ala Ala Gly Ala Pro Pro Thr Ala Thr Gly Leu Ala Asp Thr Gly
 465                 470                 475                 480
 Ala Arg Glu Asp Glu Pro Ala Ser Leu Phe Leu Glu Ile Ala Gln Trp
                 485                 490                 495    
 Val Lys Ser Thr Gln Gly Ala Gln Ser Thr Pro Ala Arg Pro Pro Thr
             500                 505                 510        
 Thr Pro Ser Ala Ala Cys Leu Pro Arg Pro Pro Pro Pro Gly Pro Gly
         515                 520                 525            
 Gly Arg Arg Arg Gln Pro Pro Val Arg Pro Gly Arg Val His Leu Pro
     530                 535                 540                
 Arg Pro Glu Ala Leu His Gln Ala Arg Gly Pro Ala Gly Gln
 545                 550                 555            



      <210> 992
      <211> 1115
      <212> PRT
      <213> Homo sapiens


      <400> 992
 Met Glu Pro Gln Leu Ala Glu Met Ile Lys Gln Phe Gln Ser Thr Val
   1               5                  10                  15    
 Glu Thr Trp Asp Gln Cys Glu Lys Lys Ile Lys Glu Leu Lys Ser Arg
              20                  25                  30        
 Leu Gln Val Leu Lys Ala Gln Ser Glu Asp Pro Leu Pro Glu Leu His
          35                  40                  45            
 Glu Asp Leu His Asn Glu Lys Glu Leu Ile Lys Glu Leu Glu Gln Ser
      50                  55                  60                
 Leu Ala Ser Trp Thr Gln Asn Leu Lys Glu Leu Gln Thr Met Lys Ala
  65                  70                  75                  80
 Asp Leu Thr Arg His Val Leu Val Glu Asp Val Met Val Leu Lys Glu
                  85                  90                  95    
 Gln Ile Glu His Leu His Arg Gln Trp Glu Asp Leu Cys Leu Arg Val
             100                 105                 110        
 Ala Ile Arg Lys Gln Glu Ile Glu Asp Arg Leu Asn Thr Trp Val Val
         115                 120                 125            
 Phe Asn Glu Lys Asn Lys Glu Leu Cys Ala Trp Leu Val Gln Met Glu
     130                 135                 140                
 Asn Lys Val Leu Gln Thr Ala Asp Ile Ser Ile Glu Glu Met Ile Glu
 145                 150                 155                 160
 Lys Leu Gln Lys Asp Cys Met Glu Glu Ile Asn Leu Phe Ser Glu Asn
                 165                 170                 175    
 Lys Leu Gln Leu Lys Gln Met Gly Asp Gln Leu Ile Lys Ala Ser Asn
             180                 185                 190        
 Lys Ser Arg Ala Ala Glu Ile Asp Asp Lys Leu Asn Lys Ile Asn Asp
         195                 200                 205            
 Arg Trp Gln His Leu Phe Asp Val Ile Gly Ser Arg Val Lys Lys Leu
     210                 215                 220                
 Lys Glu Thr Phe Ala Phe Ile Gln Gln Leu Asp Lys Asn Met Ser Asn
 225                 230                 235                 240
 Leu Arg Thr Trp Leu Ala Arg Ile Glu Ser Glu Leu Ser Lys Pro Val
                 245                 250                 255    
 Val Tyr Asp Val Cys Asp Asp Gln Glu Ile Gln Lys Arg Leu Ala Glu
             260                 265                 270        
 Gln Gln Asp Leu Gln Arg Asp Ile Glu Gln His Ser Ala Gly Val Glu
         275                 280                 285            
 Ser Val Phe Asn Ile Cys Asp Val Leu Leu His Asp Ser Asp Ala Cys
     290                 295                 300                
 Ala Asn Glu Thr Glu Cys Asp Ser Ile Gln Gln Thr Thr Arg Ser Leu
 305                 310                 315                 320
 Asp Arg Arg Trp Arg Asn Ile Cys Ala Met Ser Met Glu Arg Arg Met
                 325                 330                 335    
 Lys Ile Glu Glu Thr Trp Arg Leu Trp Gln Lys Phe Leu Asp Asp Tyr
             340                 345                 350        
 Ser Arg Phe Glu Asp Trp Leu Lys Ser Ala Glu Arg Thr Ala Ala Cys
         355                 360                 365            
 Pro Asn Ser Ser Glu Val Leu Tyr Thr Ser Ala Lys Glu Glu Leu Lys
     370                 375                 380                
 Arg Phe Glu Ala Phe Gln Arg Gln Ile His Glu Arg Leu Thr Gln Leu
 385                 390                 395                 400
 Glu Leu Ile Asn Lys Gln Tyr Arg Arg Leu Ala Arg Glu Asn Arg Thr
                 405                 410                 415    
 Asp Thr Ala Ser Arg Leu Lys Gln Met Val His Glu Gly Asn Gln Arg
             420                 425                 430        
 Trp Asp Asn Leu Gln Arg Arg Val Thr Ala Val Leu Arg Arg Leu Arg
         435                 440                 445            
 His Phe Thr Asn Gln Arg Glu Glu Phe Glu Gly Thr Arg Glu Ser Ile
     450                 455                 460                
 Leu Val Trp Leu Thr Glu Met Asp Leu Gln Leu Thr Asn Val Glu His
 465                 470                 475                 480
 Phe Ser Glu Ser Asp Ala Asp Asp Lys Met Arg Gln Leu Asn Gly Phe
                 485                 490                 495    
 Gln Gln Glu Ile Thr Leu Asn Thr Asn Lys Ile Asp Gln Leu Ile Val
             500                 505                 510        
 Phe Gly Glu Gln Leu Ile Gln Lys Ser Glu Pro Leu Asp Ala Val Leu
         515                 520                 525            
 Ile Glu Asp Glu Leu Glu Glu Leu His Arg Tyr Cys Gln Glu Val Phe
     530                 535                 540                
 Gly Arg Val Ser Arg Phe His Arg Arg Leu Thr Ser Cys Thr Pro Gly
 545                 550                 555                 560
 Leu Glu Asp Glu Lys Glu Ala Ser Glu Asn Glu Thr Asp Met Glu Asp
                 565                 570                 575    
 Pro Arg Glu Ile Gln Thr Asp Ser Trp Arg Lys Arg Gly Glu Ser Glu
             580                 585                 590        
 Glu Pro Ser Ser Pro Gln Ser Leu Cys His Leu Val Ala Pro Gly His
         595                 600                 605            
 Glu Arg Ser Gly Cys Glu Thr Pro Val Ser Val Asp Ser Ile Pro Leu
     610                 615                 620                
 Glu Trp Asp His Thr Gly Asp Val Gly Gly Ser Ser Ser His Glu Glu
 625                 630                 635                 640
 Asp Glu Glu Gly Pro Tyr Tyr Ser Ala Leu Ser Asp Val Glu Ile Pro
                 645                 650                 655    
 Glu Asn Pro Glu Ala Tyr Leu Lys Met Thr Thr Lys Thr Leu Lys Ala
             660                 665                 670        
 Ser Ser Gly Lys Ser Ile Ser Asp Gly His Ser Trp His Val Pro Asp
         675                 680                 685            
 Ser Pro Ser Cys Pro Glu His His Tyr Lys Gln Met Glu Gly Asp Arg
     690                 695                 700                
 Asn Val Pro Pro Val Pro Pro Ala Ser Ser Thr Pro Tyr Lys Pro Pro
 705                 710                 715                 720
 Tyr Gly Lys Leu Leu Leu Pro Pro Gly Thr Asp Gly Gly Lys Glu Gly
                 725                 730                 735    
 Pro Arg Val Leu Asn Gly Asn Pro Gln Gln Glu Asp Gly Gly Leu Ala
             740                 745                 750        
 Gly Ile Thr Glu Gln Gln Ser Gly Ala Phe Asp Arg Trp Glu Met Ile
         755                 760                 765            
 Gln Ala Gln Glu Leu His Asn Lys Leu Lys Ile Lys Gln Asn Leu Gln
     770                 775                 780                
 Gln Leu Asn Ser Asp Ile Ser Ala Ile Thr Thr Trp Leu Lys Lys Thr
 785                 790                 795                 800
 Glu Ala Glu Leu Glu Met Leu Lys Met Ala Lys Pro Pro Ser Asp Ile
                 805                 810                 815    
 Gln Glu Ile Glu Leu Arg Val Lys Arg Leu Gln Glu Ile Leu Lys Ala
             820                 825                 830        
 Phe Asp Thr Tyr Lys Ala Leu Val Val Ser Val Asn Val Ser Ser Lys
         835                 840                 845            
 Glu Phe Leu Gln Thr Glu Ser Pro Glu Ser Thr Glu Leu Gln Ser Arg
     850                 855                 860                
 Leu Arg Gln Leu Ser Leu Leu Trp Glu Ala Ala Gln Gly Ala Val Asp
 865                 870                 875                 880
 Ser Trp Arg Gly Gly Leu Arg Gln Ser Leu Met Gln Cys Gln Asp Phe
                 885                 890                 895    
 His Gln Leu Ser Gln Asn Leu Leu Leu Trp Leu Ala Ser Ala Lys Asn
             900                 905                 910        
 Arg Arg Gln Lys Ala His Val Thr Asp Pro Lys Ala Asp Pro Arg Ala
         915                 920                 925            
 Leu Leu Glu Cys Arg Arg Glu Leu Met Gln Leu Glu Lys Glu Leu Val
     930                 935                 940                
 Glu Arg Gln Pro Gln Val Asp Met Leu Gln Glu Ile Ser Asn Ser Leu
 945                 950                 955                 960
 Leu Ile Lys Gly His Gly Glu Asp Cys Ile Glu Ala Glu Glu Lys Val
                 965                 970                 975    
 His Val Ile Glu Lys Lys Leu Lys Gln Leu Arg Glu Gln Val Ser Gln
             980                 985                 990        
 Asp Leu Met Ala Leu Gln Gly Thr Gln Asn Pro Ala Ser Pro Leu Pro
         995                1000                1005            
 Ser Phe Asp Glu Val Asp Ser Gly Asp Gln Pro Pro Ala Thr Ser Val
    1010                1015                1020                
 Pro Ala Pro Arg Ala Lys Gln Phe Arg Ala Val Arg Thr Thr Glu Gly
1025                1030                1035                1040
 Glu Glu Glu Thr Glu Ser Arg Val Pro Gly Ser Thr Arg Pro Gln Arg
                1045                1050                1055    
 Ser Phe Leu Ser Arg Val Val Arg Ala Ala Leu Pro Leu Gln Leu Leu
            1060                1065                1070        
 Leu Leu Leu Leu Leu Leu Leu Ala Cys Leu Leu Pro Ser Ser Glu Glu
        1075                1080                1085            
 Asp Tyr Ser Cys Thr Gln Ala Asn Asn Phe Ala Arg Ser Phe Tyr Pro
    1090                1095                1100                
 Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Thr
1105                1110                1115



      <210> 993
      <211> 190
      <212> PRT
      <213> Homo sapiens


      <400> 993
 Met Lys Ala Ser Gln Cys Cys Cys Cys Leu Ser His Leu Leu Ala Ser
   1               5                  10                  15    
 Val Leu Leu Leu Leu Leu Leu Pro Glu Leu Ser Gly Pro Leu Ala Val
              20                  25                  30        
 Leu Leu Gln Ala Ala Glu Ala Ala Pro Gly Leu Gly Pro Pro Asp Pro
          35                  40                  45            
 Arg Pro Arg Thr Leu Pro Pro Leu Pro Pro Gly Pro Thr Pro Ala Gln
      50                  55                  60                
 Gln Pro Gly Arg Gly Leu Ala Glu Ala Ala Gly Pro Arg Gly Ser Glu
  65                  70                  75                  80
 Gly Gly Asn Gly Ser Asn Pro Val Ala Gly Leu Glu Thr Asp Asp His
                  85                  90                  95    
 Gly Gly Lys Ala Gly Glu Gly Ser Val Gly Gly Gly Leu Ala Val Ser
             100                 105                 110        
 Pro Asn Pro Gly Asp Lys Pro Met Thr Gln Arg Ala Leu Thr Val Leu
         115                 120                 125            
 Met Val Val Ser Gly Ala Val Leu Val Tyr Phe Val Val Arg Thr Val
     130                 135                 140                
 Arg Met Arg Arg Arg Asn Arg Lys Thr Arg Arg Tyr Gly Val Leu Asp
 145                 150                 155                 160
 Thr Asn Ile Glu Asn Met Glu Leu Thr Pro Leu Glu Gln Asp Asp Glu
                 165                 170                 175    
 Asp Asp Asp Asn Thr Leu Phe Asp Ala Asn His Pro Arg Arg
             180                 185                 190



      <210> 994
      <211> 287
      <212> PRT
      <213> Homo sapiens


      <400> 994
 Met Ala Leu Gly Leu Leu Ile Ala Val Pro Leu Leu Leu Gln Ala Ala
   1               5                  10                  15    
 Pro Arg Gly Ala Ala His Tyr Glu Met Met Gly Thr Cys Arg Met Ile
              20                  25                  30        
 Cys Asp Pro Tyr Thr Ala Ala Pro Gly Gly Glu Pro Pro Gly Ala Lys
          35                  40                  45            
 Ala Gln Pro Pro Gly Pro Ser Thr Ala Ala Leu Glu Val Met Gln Asp
      50                  55                  60                
 Leu Ser Ala Asn Pro Pro Pro Pro Phe Ile Gln Gly Pro Lys Gly Asp
  65                  70                  75                  80
 Pro Gly Arg Pro Gly Lys Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro
                  85                  90                  95    
 Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu Lys Gly Asp Ser Gly
             100                 105                 110        
 Arg Pro Gly Leu Pro Gly Leu Gln Leu Thr Ala Gly Thr Ala Ser Gly
         115                 120                 125            
 Val Gly Val Val Gly Gly Gly Ala Gly Val Gly Gly Asp Ser Glu Gly
     130                 135                 140                
 Glu Val Thr Ser Ala Leu Ser Ala Thr Phe Ser Gly Pro Lys Ile Ala
 145                 150                 155                 160
 Phe Tyr Val Gly Leu Lys Ser Pro His Glu Gly Tyr Glu Val Leu Lys
                 165                 170                 175    
 Phe Asp Asp Val Val Thr Asn Leu Gly Asn His Tyr Asp Pro Thr Thr
             180                 185                 190        
 Gly Lys Phe Ser Cys Gln Val Arg Gly Ile Tyr Phe Phe Thr Tyr His
         195                 200                 205            
 Ile Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Cys
     210                 215                 220                
 Lys Asn Gly Gln Val Arg Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln
 225                 230                 235                 240
 Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu Asp Ser Gly
                 245                 250                 255    
 Asp Glu Val Tyr Val Lys Leu Asp Gly Gly Lys Ala His Gly Gly Asn
             260                 265                 270        
 Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe Leu Leu Tyr Pro Asp
         275                 280                 285        



      <210> 995
      <211> 345
      <212> PRT
      <213> Homo sapiens


      <400> 995
 Met Asp Gly Trp Glu Thr Arg Arg Lys Arg Ile Pro Gly His Asp Trp
   1               5                  10                  15    
 Cys Val Leu Arg Leu Gly Ile Gln Gly Val Ile Arg Gly Phe Asp Val
              20                  25                  30        
 Asp Val Ser Tyr Phe Thr Gly Asp Tyr Ala Pro Arg Val Ser Ile Gln
          35                  40                  45            
 Ala Ala Asn Leu Glu Glu Asp Lys Leu Pro Glu Ile Pro Glu Arg Gly
      50                  55                  60                
 Thr Arg Thr Gly Ala Ala Ala Thr Pro Glu Glu Phe Glu Ala Ile Ala
  65                  70                  75                  80
 Glu Leu Lys Ser Asp Asp Trp Ser Tyr Leu Val Pro Met Thr Glu Leu
                  85                  90                  95    
 Lys Pro Gly Asn Pro Ala Ser Gly His Asn Tyr Phe Leu Val Asn Ser
             100                 105                 110        
 Gln Gln Arg Trp Thr His Ile Arg Leu Asn Ile Phe Pro Asp Gly Gly
         115                 120                 125            
 Ile Ala Arg Leu Arg Val Phe Gly Thr Gly Gln Lys Asp Trp Thr Ala
     130                 135                 140                
 Thr Asp Pro Lys Glu Pro Ala Asp Leu Val Ala Ile Ala Phe Gly Gly
 145                 150                 155                 160
 Val Cys Val Gly Leu Ser Asn Ala Lys Phe Gly His Pro Asn Asn Ile
                 165                 170                 175    
 Ile Gly Val Gly Gly Ala Lys Ser Met Ala Asp Gly Trp Glu Thr Ala
             180                 185                 190        
 Arg Arg Leu Asp Arg Pro Pro Ile Leu Glu Asn Asp Glu Asn Gly Ile
         195                 200                 205            
 Leu Leu Val Pro Gly Cys Glu Trp Ala Val Phe Arg Leu Ala His Pro
     210                 215                 220                
 Gly Val Ile Thr Arg Ile Glu Ile Asp Thr Lys Tyr Phe Glu Gly Asn
 225                 230                 235                 240
 Ala Pro Asp Ser Cys Lys Val Asp Gly Cys Ile Leu Thr Thr Gln Glu
                 245                 250                 255    
 Glu Ala Val Ile Arg Gln Lys Trp Ile Leu Pro Ala His Lys Trp Lys
             260                 265                 270        
 Pro Leu Leu Pro Val Thr Lys Leu Ser Pro Asn Gln Ser His Leu Phe
         275                 280                 285            
 Asp Ser Leu Thr Leu Glu Leu Gln Asp Val Ile Thr His Ala Arg Leu
     290                 295                 300                
 Thr Ile Val Pro Asp Gly Gly Val Ser Arg Leu Arg Leu Arg Gly Phe
 305                 310                 315                 320
 Pro Ser Ser Ile Cys Leu Leu Arg Pro Arg Glu Lys Pro Met Leu Lys
                 325                 330                 335    
 Phe Ser Val Ser Phe Lys Ala Asn Pro
             340                 345



      <210> 996
      <211> 525
      <212> PRT
      <213> Homo sapiens


      <400> 996
 Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp
   1               5                  10                  15    
 Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val
              20                  25                  30        
 Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile
          35                  40                  45            
 Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln
      50                  55                  60                
 His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu
  65                  70                  75                  80
 Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro
                  85                  90                  95    
 Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly
             100                 105                 110        
 Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln
         115                 120                 125            
 Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala
     130                 135                 140                
 Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys
 145                 150                 155                 160
 Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro
                 165                 170                 175    
 Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser
             180                 185                 190        
 Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln
         195                 200                 205            
 Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser
     210                 215                 220                
 Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly
 225                 230                 235                 240
 Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn
                 245                 250                 255    
 Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala
             260                 265                 270        
 Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val
         275                 280                 285            
 Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly
     290                 295                 300                
 Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu
 305                 310                 315                 320
 Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His
                 325                 330                 335    
 Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr
             340                 345                 350        
 Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu
         355                 360                 365            
 Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser
     370                 375                 380                
 Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala
 385                 390                 395                 400
 Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln
                 405                 410                 415    
 Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser
             420                 425                 430        
 Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly
         435                 440                 445            
 His Leu Leu Leu Phe Leu Thr Leu Gly Val Leu Ser Leu Leu Leu Leu
     450                 455                 460                
 Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro
 465                 470                 475                 480
 Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Arg Gln Ala Gln
                 485                 490                 495    
 Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro
             500                 505                 510        
 Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu
         515                 520                 525



      <210> 997
      <211> 1237
      <212> PRT
      <213> Homo sapiens


      <400> 997
 Met Gln Lys Ser Val Arg Tyr Asn Glu Gly His Ala Leu Tyr Leu Ala
   1               5                  10                  15    
 Phe Leu Ala Arg Lys Glu Gly Thr Lys Arg Gly Phe Leu Ser Lys Lys
              20                  25                  30        
 Thr Ala Glu Ala Ser Arg Trp His Glu Lys Trp Phe Ala Leu Tyr Gln
          35                  40                  45            
 Asn Val Leu Phe Tyr Phe Glu Gly Glu Gln Ser Cys Arg Pro Ala Gly
      50                  55                  60                
 Met Tyr Leu Leu Glu Gly Cys Ser Cys Glu Arg Thr Pro Ala Pro Pro
  65                  70                  75                  80
 Arg Ala Gly Ala Gly Gln Gly Gly Val Arg Asp Ala Leu Asp Lys Gln
                  85                  90                  95    
 Tyr Tyr Phe Thr Val Leu Phe Gly His Glu Gly Gln Lys Pro Leu Glu
             100                 105                 110        
 Leu Arg Cys Glu Glu Glu Gln Asp Gly Lys Glu Trp Met Glu Ala Ile
         115                 120                 125            
 His Gln Ala Ser Tyr Ala Asp Ile Leu Ile Glu Arg Glu Val Leu Met
     130                 135                 140                
 Gln Lys Tyr Ile His Leu Val Gln Ile Val Glu Thr Glu Lys Ile Ala
 145                 150                 155                 160
 Ala Asn Gln Leu Arg His Gln Leu Glu Asp Gln Asp Thr Glu Ile Glu
                 165                 170                 175    
 Arg Leu Lys Ser Glu Ile Ile Ala Leu Asn Lys Thr Lys Glu Arg Met
             180                 185                 190        
 Arg Pro Tyr Gln Ser Asn Gln Glu Asp Glu Asp Pro Asp Ile Lys Lys
         195                 200                 205            
 Ile Lys Lys Val Gln Ser Phe Met Arg Gly Trp Leu Cys Arg Arg Lys
     210                 215                 220                
 Trp Lys Thr Ile Val Gln Asp Tyr Ile Cys Ser Pro His Ala Glu Ser
 225                 230                 235                 240
 Met Arg Lys Arg Asn Gln Ile Val Phe Thr Met Val Glu Ala Glu Ser
                 245                 250                 255    
 Glu Tyr Val His Gln Leu Tyr Ile Leu Val Asn Gly Phe Leu Arg Pro
             260                 265                 270        
 Leu Arg Met Ala Ala Ser Ser Lys Lys Pro Pro Ile Ser His Asp Asp
         275                 280                 285            
 Val Ser Ser Ile Phe Leu Asn Ser Glu Thr Ile Met Phe Leu His Glu
     290                 295                 300                
 Ile Phe His Gln Gly Leu Lys Ala Arg Ile Ala Asn Trp Pro Thr Leu
 305                 310                 315                 320
 Ile Leu Ala Asp Leu Phe Asp Ile Leu Leu Pro Met Leu Asn Ile Tyr
                 325                 330                 335    
 Gln Glu Phe Val Arg Asn His Gln Tyr Ser Leu Gln Val Leu Ala Asn
             340                 345                 350        
 Cys Lys Gln Asn Arg Asp Phe Asp Lys Leu Leu Lys Gln Tyr Glu Ala
         355                 360                 365            
 Asn Pro Ala Cys Glu Gly Arg Met Leu Glu Thr Phe Leu Thr Tyr Pro
     370                 375                 380                
 Met Phe Gln Ile Pro Arg Tyr Ile Ile Thr Leu His Glu Leu Leu Ala
 385                 390                 395                 400
 His Thr Pro His Glu His Val Glu Arg Lys Ser Leu Glu Phe Ala Lys
                 405                 410                 415    
 Ser Lys Leu Glu Glu Leu Ser Arg Val Met His Asp Glu Val Ser Asp
             420                 425                 430        
 Thr Glu Asn Ile Arg Lys Asn Leu Ala Ile Glu Arg Met Ile Val Glu
         435                 440                 445            
 Gly Cys Asp Ile Leu Leu Asp Thr Ser Gln Thr Phe Ile Arg Gln Gly
     450                 455                 460                
 Ser Leu Ile Gln Val Pro Ser Val Glu Arg Gly Lys Leu Ser Lys Val
 465                 470                 475                 480
 Arg Leu Gly Ser Leu Ser Leu Lys Lys Glu Gly Glu Arg Gln Cys Phe
                 485                 490                 495    
 Leu Phe Thr Lys His Phe Leu Ile Cys Thr Arg Ser Ser Gly Gly Lys
             500                 505                 510        
 Leu His Leu Leu Lys Thr Gly Gly Val Leu Ser Leu Ile Asp Cys Thr
         515                 520                 525            
 Leu Ile Glu Glu Pro Asp Ala Ser Asp Asp Asp Ser Lys Gly Ser Gly
     530                 535                 540                
 Gln Val Phe Gly His Leu Asp Phe Lys Ile Val Val Glu Pro Pro Asp
 545                 550                 555                 560
 Arg Ala Ala Phe Thr Val Val Leu Leu Ala Pro Ser Arg Gln Glu Lys
                 565                 570                 575    
 Ala Ala Trp Met Ser Asp Ile Ser Gln Cys Val Asp Asn Ile Arg Cys
             580                 585                 590        
 Asn Gly Leu Met Thr Ile Val Phe Glu Glu Asn Ser Lys Val Thr Val
         595                 600                 605            
 Pro His Met Ile Lys Ser Asp Ala Arg Leu His Lys Asp Asp Thr Asp
     610                 615                 620                
 Ile Cys Phe Ser Lys Thr Leu Asn Ser Cys Lys Val Pro Gln Ile Arg
 625                 630                 635                 640
 Tyr Ala Ser Val Glu Arg Leu Leu Glu Arg Leu Thr Asp Leu Arg Phe
                 645                 650                 655    
 Leu Ser Ile Asp Phe Leu Asn Thr Phe Leu His Thr Tyr Arg Ile Phe
             660                 665                 670        
 Thr Thr Ala Ala Val Val Leu Gly Lys Leu Ser Asp Ile Tyr Lys Arg
         675                 680                 685            
 Pro Phe Thr Ser Ile Pro Val Arg Ser Leu Glu Leu Phe Phe Ala Thr
     690                 695                 700                
 Ser Gln Asn Asn Arg Gly Glu His Leu Val Asp Gly Lys Ser Pro Arg
 705                 710                 715                 720
 Leu Cys Arg Lys Phe Ser Ser Pro Pro Pro Leu Ala Val Ser Arg Thr
                 725                 730                 735    
 Ser Ser Pro Val Arg Ala Arg Lys Leu Ser Leu Thr Ser Pro Leu Asn
             740                 745                 750        
 Ser Lys Ile Gly Ala Leu Asp Leu Thr Thr Ser Ser Ser Pro Thr Thr
         755                 760                 765            
 Thr Thr Gln Ser Pro Ala Ala Ser Pro Pro Pro His Thr Gly Gln Ile
     770                 775                 780                
 Pro Leu Asp Leu Ser Arg Gly Leu Ser Ser Pro Glu Gln Ser Pro Gly
 785                 790                 795                 800
 Thr Val Glu Glu Asn Val Asp Asn Pro Arg Val Asp Leu Cys Asn Lys
                 805                 810                 815    
 Leu Lys Arg Ser Ile Gln Ala Ala Val Leu Glu Ser Ala Pro Ala Asp
             820                 825                 830        
 Arg Ala Gly Val Glu Ser Ser Pro Ala Ala Asp Thr Thr Glu Leu Ser
         835                 840                 845            
 Pro Cys Arg Ser Pro Ser Thr Pro Arg His Leu Arg Tyr Arg Gln Pro
     850                 855                 860                
 Gly Gly Gln Thr Ala Asp Asn Ala His Cys Ser Val Ser Pro Ala Ser
 865                 870                 875                 880
 Ala Phe Ala Ile Ala Thr Ala Ala Ala Gly His Gly Ser Pro Pro Gly
                 885                 890                 895    
 Phe Asn Asn Thr Glu Arg Thr Cys Asp Lys Glu Phe Ile Ile Arg Arg
             900                 905                 910        
 Thr Ala Thr Asn Arg Val Leu Asn Val Leu Arg His Trp Val Ser Lys
         915                 920                 925            
 His Ala Gln Asp Phe Glu Leu Asn Asn Glu Leu Lys Met Asn Val Leu
     930                 935                 940                
 Asn Leu Leu Glu Glu Val Leu Arg Asp Pro Asp Leu Leu Pro Gln Glu
 945                 950                 955                 960
 Arg Lys Ala Ala Ala Asn Ile Leu Arg Ala Leu Ser Gln Asp Asp Gln
                 965                 970                 975    
 Asp Asp Ile His Leu Lys Leu Glu Asp Ile Ile Gln Met Thr Asp Cys
             980                 985                 990        
 Met Lys Ala Glu Cys Phe Glu Ser Leu Ser Ala Met Glu Leu Ala Glu
         995                1000                1005            
 Gln Ile Thr Leu Leu Asp His Val Ile Phe Arg Ser Ile Pro Tyr Glu
    1010                1015                1020                
 Glu Phe Leu Gly Gln Gly Trp Met Lys Leu Asp Lys Asn Glu Arg Thr
1025                1030                1035                1040
 Pro Tyr Ile Met Lys Thr Ser Gln His Phe Asn Asp Met Ser Asn Leu
                1045                1050                1055    
 Val Ala Ser Gln Ile Met Asn Tyr Ala Asp Val Ser Ser Arg Ala Asn
            1060                1065                1070        
 Ala Ile Glu Lys Trp Val Ala Val Ala Asp Ile Cys Arg Cys Leu His
        1075                1080                1085            
 Asn Tyr Asn Gly Val Leu Glu Ile Thr Ser Ala Leu Asn Arg Ser Ala
    1090                1095                1100                
 Ile Tyr Arg Leu Lys Lys Thr Trp Ala Lys Val Ser Lys Gln Thr Lys
1105                1110                1115                1120
 Ala Leu Met Asp Lys Leu Gln Lys Thr Val Ser Ser Glu Gly Arg Phe
                1125                1130                1135    
 Lys Asn Leu Arg Glu Thr Leu Lys Asn Cys Asn Pro Pro Ala Val Pro
            1140                1145                1150        
 Tyr Leu Gly Met Tyr Leu Thr Asp Leu Ala Phe Ile Glu Glu Gly Thr
        1155                1160                1165            
 Pro Asn Phe Thr Glu Glu Gly Leu Val Asn Phe Ser Lys Met Arg Met
    1170                1175                1180                
 Ile Ser His Ile Ile Arg Glu Ile Arg Gln Phe Gln Gln Thr Ser Tyr
1185                1190                1195                1200
 Arg Ile Asp His Gln Pro Lys Val Ala Gln Tyr Leu Leu Asp Lys Asp
                1205                1210                1215    
 Leu Ile Ile Asp Glu Asp Thr Leu Tyr Glu Leu Ser Leu Lys Ile Glu
            1220                1225                1230        
 Pro Arg Leu Pro Ala
        1235        



      <210> 998
      <211> 1642
      <212> PRT
      <213> Homo sapiens


      <400> 998
 Met Leu Ala Thr Thr Ser Pro Ala Leu Met Asn Gly Ser Gly Gln Ser
   1               5                  10                  15    
 Pro Ser Val Leu Lys Gly Ile Leu His Glu Ala Ala Met Gln Tyr Pro
              20                  25                  30        
 Lys Gln Gly Ile Phe Ser Val Thr Cys Pro His Pro Asp Ile Phe Leu
          35                  40                  45            
 Val Ala Arg Ile Glu Lys Val Leu Gln Gly Ser Ile Thr His Cys Ala
      50                  55                  60                
 Glu Pro Tyr Met Lys Ser Ser Asp Ser Ser Lys Val Ala Gln Lys Val
  65                  70                  75                  80
 Leu Lys Asn Ala Lys Gln Ala Cys Gln Arg Leu Gly Gln Tyr Arg Met
                  85                  90                  95    
 Pro Phe Ala Trp Ala Ala Arg Thr Leu Phe Lys Asp Ala Ser Gly Asn
             100                 105                 110        
 Leu Asp Lys Asn Ala Arg Phe Ser Ala Ile Tyr Arg Gln Asp Ser Asn
         115                 120                 125            
 Lys Leu Ser Asn Asp Asp Met Leu Lys Leu Leu Ala Asp Phe Arg Lys
     130                 135                 140                
 Pro Glu Lys Met Ala Lys Leu Pro Val Ile Leu Gly Asn Leu Asp Ile
 145                 150                 155                 160
 Thr Ile Asp Asn Val Ser Ser Asp Phe Pro Asn Tyr Val Asn Ser Ser
                 165                 170                 175    
 Tyr Ile Pro Thr Lys Gln Phe Glu Thr Cys Ser Lys Thr Pro Ile Thr
             180                 185                 190        
 Phe Glu Val Glu Glu Phe Val Pro Cys Ile Pro Lys His Thr Gln Pro
         195                 200                 205            
 Tyr Thr Ile Tyr Thr Asn His Leu Tyr Val Tyr Pro Lys Tyr Leu Lys
     210                 215                 220                
 Tyr Asp Ser Gln Lys Ser Phe Ala Lys Ala Arg Asn Ile Ala Ile Cys
 225                 230                 235                 240
 Ile Glu Phe Lys Asp Ser Asp Glu Glu Asp Ser Gln Pro Leu Lys Cys
                 245                 250                 255    
 Ile Tyr Gly Arg Pro Gly Gly Pro Val Phe Thr Arg Ser Ala Phe Ala
             260                 265                 270        
 Ala Val Leu His His His Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys
         275                 280                 285            
 Ile Glu Leu Pro Thr Gln Leu His Glu Lys His His Leu Leu Leu Thr
     290                 295                 300                
 Phe Phe His Val Ser Cys Asp Asn Ser Ser Lys Gly Ser Thr Lys Lys
 305                 310                 315                 320
 Arg Asp Val Val Glu Thr Gln Val Gly Tyr Ser Trp Leu Pro Leu Leu
                 325                 330                 335    
 Lys Asp Gly Arg Val Val Thr Ser Glu Gln His Ile Pro Val Ser Ala
             340                 345                 350        
 Asn Leu Pro Ser Gly Tyr Leu Gly Tyr Gln Glu Leu Gly Met Gly Arg
         355                 360                 365            
 His Tyr Gly Pro Glu Ile Lys Trp Val Asp Gly Gly Lys Pro Leu Leu
     370                 375                 380                
 Lys Ile Ser Thr His Leu Val Ser Thr Val Tyr Thr Gln Asp Gln His
 385                 390                 395                 400
 Leu His Asn Phe Phe Gln Tyr Cys Gln Lys Thr Glu Ser Gly Ala Gln
                 405                 410                 415    
 Ala Leu Gly Asn Glu Leu Val Lys Tyr Leu Lys Ser Leu His Ala Met
             420                 425                 430        
 Glu Gly His Val Met Ile Ala Phe Leu Pro Thr Ile Leu Asn Gln Leu
         435                 440                 445            
 Phe Arg Val Leu Thr Arg Ala Thr Gln Glu Glu Val Ala Val Asn Val
     450                 455                 460                
 Thr Arg Val Ile Ile His Val Val Ala Gln Cys His Glu Glu Gly Leu
 465                 470                 475                 480
 Glu Ser His Leu Arg Ser Tyr Val Lys Tyr Ala Tyr Lys Ala Glu Pro
                 485                 490                 495    
 Tyr Val Ala Ser Glu Tyr Lys Thr Val His Glu Glu Leu Thr Lys Ser
             500                 505                 510        
 Met Thr Thr Ile Leu Lys Pro Ser Ala Asp Phe Leu Thr Ser Asn Lys
         515                 520                 525            
 Leu Leu Lys Tyr Ser Trp Phe Phe Phe Asp Val Leu Ile Lys Ser Met
     530                 535                 540                
 Ala Gln His Leu Ile Glu Asn Ser Lys Val Lys Leu Leu Arg Asn Gln
 545                 550                 555                 560
 Arg Phe Pro Ala Ser Tyr His His Ala Val Glu Thr Val Val Asn Met
                 565                 570                 575    
 Leu Met Pro His Ile Thr Gln Lys Phe Arg Asp Asn Pro Glu Ala Ser
             580                 585                 590        
 Lys Asn Ala Asn His Ser Leu Ala Val Phe Ile Lys Arg Cys Phe Thr
         595                 600                 605            
 Phe Met Asp Arg Gly Phe Val Phe Lys Gln Ile Asn Asn Tyr Ile Ser
     610                 615                 620                
 Cys Phe Ala Pro Gly Asp Pro Lys Thr Leu Phe Glu Tyr Lys Phe Glu
 625                 630                 635                 640
 Phe Leu Arg Val Val Cys Asn His Glu His Tyr Ile Pro Leu Asn Leu
                 645                 650                 655    
 Pro Met Pro Phe Gly Lys Gly Arg Ile Gln Arg Tyr Gln Asp Leu Gln
             660                 665                 670        
 Leu Asp Tyr Ser Leu Thr Asp Glu Phe Cys Arg Asn His Phe Leu Val
         675                 680                 685            
 Gly Leu Leu Leu Arg Glu Val Gly Thr Ala Leu Gln Glu Phe Arg Glu
     690                 695                 700                
 Val Arg Leu Ile Ala Ile Ser Val Leu Lys Asn Leu Leu Ile Lys His
 705                 710                 715                 720
 Ser Phe Asp Asp Arg Tyr Ala Ser Arg Ser His Gln Ala Arg Ile Ala
                 725                 730                 735    
 Thr Leu Tyr Leu Pro Leu Phe Gly Leu Leu Ile Glu Asn Val Gln Arg
             740                 745                 750        
 Ile Asn Val Arg Asp Val Ser Pro Phe Pro Val Asn Ala Gly Met Thr
         755                 760                 765            
 Val Lys Asp Glu Ser Leu Ala Leu Pro Ala Val Asn Pro Leu Val Thr
     770                 775                 780                
 Pro Gln Lys Gly Ser Thr Leu Asp Asn Ser Leu His Lys Asp Leu Leu
 785                 790                 795                 800
 Gly Ala Ile Ser Gly Ile Ala Ser Pro Tyr Thr Thr Ser Thr Pro Asn
                 805                 810                 815    
 Ile Asn Ser Val Arg Asn Ala Asp Ser Arg Gly Ser Leu Ile Ser Thr
             820                 825                 830        
 Asp Ser Gly Asn Ser Leu Pro Glu Arg Asn Ser Glu Lys Ser Asn Ser
         835                 840                 845            
 Leu Asp Lys His Gln Gln Ser Ser Thr Leu Gly Asn Ser Val Val Arg
     850                 855                 860                
 Cys Asp Lys Leu Asp Gln Ser Glu Ile Lys Ser Leu Leu Met Cys Phe
 865                 870                 875                 880
 Leu Tyr Ile Leu Lys Ser Met Ser Asp Asp Ala Leu Phe Thr Tyr Trp
                 885                 890                 895    
 Asn Lys Ala Ser Thr Ser Glu Leu Met Asp Phe Phe Thr Ile Ser Glu
             900                 905                 910        
 Val Cys Leu His Gln Phe Gln Tyr Met Gly Lys Arg Tyr Ile Ala Arg
         915                 920                 925            
 Thr Gly Met Met His Ala Arg Leu Gln Gln Leu Gly Ser Leu Asp Asn
     930                 935                 940                
 Ser Leu Thr Phe Asn His Ser Tyr Gly His Ser Asp Ala Asp Val Leu
 945                 950                 955                 960
 His Gln Ser Leu Leu Glu Ala Asn Ile Ala Thr Glu Val Cys Leu Thr
                 965                 970                 975    
 Ala Leu Asp Thr Leu Ser Leu Phe Thr Leu Ala Phe Lys Asn Gln Leu
             980                 985                 990        
 Leu Ala Asp His Gly His Asn Pro Leu Met Lys Lys Val Phe Asp Val
         995                1000                1005            
 Tyr Leu Cys Phe Leu Gln Lys His Gln Ser Glu Thr Ala Leu Lys Asn
    1010                1015                1020                
 Val Phe Thr Ala Leu Arg Ser Leu Ile Tyr Lys Phe Pro Ser Thr Phe
1025                1030                1035                1040
 Tyr Glu Gly Arg Ala Asp Met Cys Ala Ala Leu Cys Tyr Glu Ile Leu
                1045                1050                1055    
 Lys Cys Cys Asn Ser Lys Leu Ser Ser Ile Arg Thr Glu Ala Ser Gln
            1060                1065                1070        
 Leu Leu Tyr Phe Leu Met Arg Asn Asn Phe Asp Tyr Thr Gly Lys Lys
        1075                1080                1085            
 Ser Phe Val Arg Thr His Leu Gln Val Ile Ile Ser Val Ser Gln Leu
    1090                1095                1100                
 Ile Ala Asp Val Val Gly Ile Gly Gly Thr Arg Phe Gln Gln Ser Leu
1105                1110                1115                1120
 Ser Ile Ile Asn Asn Cys Ala Asn Ser Asp Arg Leu Ile Lys His Thr
                1125                1130                1135    
 Ser Phe Ser Ser Asp Val Lys Asp Leu Thr Lys Arg Ile Arg Thr Val
            1140                1145                1150        
 Leu Met Ala Thr Ala Gln Met Lys Glu His Glu Asn Asp Pro Glu Met
        1155                1160                1165            
 Leu Val Asp Leu Gln Tyr Ser Leu Ala Lys Ser Tyr Ala Ser Thr Pro
    1170                1175                1180                
 Glu Leu Arg Lys Thr Trp Leu Asp Ser Met Ala Arg Ile His Val Lys
1185                1190                1195                1200
 Asn Gly Asp Leu Ser Glu Ala Ala Met Cys Tyr Val His Val Thr Ala
                1205                1210                1215    
 Leu Val Ala Glu Tyr Leu Thr Arg Lys Glu Ala Val Gln Trp Glu Pro
            1220                1225                1230        
 Pro Leu Leu Pro His Ser His Ser Ala Cys Leu Arg Arg Ser Arg Gly
        1235                1240                1245            
 Gly Val Phe Arg Gln Gly Cys Thr Ala Phe Arg Val Ile Thr Pro Asn
    1250                1255                1260                
 Ile Asp Glu Glu Ala Ser Met Met Glu Asp Val Gly Met Gln Asp Val
1265                1270                1275                1280
 His Phe Asn Glu Asp Val Leu Met Glu Leu Leu Glu Gln Cys Ala Asp
                1285                1290                1295    
 Gly Leu Trp Lys Ala Glu Arg Tyr Glu Leu Ile Ala Asp Ile Tyr Lys
            1300                1305                1310        
 Leu Ile Ile Pro Ile Tyr Glu Lys Arg Arg Asp Phe Glu Arg Leu Ala
        1315                1320                1325            
 His Leu Tyr Asp Thr Leu His Arg Ala Tyr Ser Lys Val Thr Glu Val
    1330                1335                1340                
 Met His Ser Gly Arg Arg Leu Leu Gly Thr Tyr Phe Arg Val Ala Phe
1345                1350                1355                1360
 Phe Gly Gln Ala Ala Gln Tyr Gln Phe Thr Asp Ser Glu Thr Asp Val
                1365                1370                1375    
 Glu Gly Phe Phe Glu Asp Glu Asp Gly Lys Glu Tyr Ile Tyr Lys Glu
            1380                1385                1390        
 Pro Lys Leu Thr Pro Leu Ser Glu Ile Ser Gln Arg Leu Leu Lys Leu
        1395                1400                1405            
 Tyr Ser Asp Lys Phe Gly Ser Glu Asn Val Lys Met Ile Gln Asp Ser
    1410                1415                1420                
 Gly Lys Val Asn Pro Lys Asp Leu Asp Ser Lys Tyr Ala Tyr Ile Gln
1425                1430                1435                1440
 Val Thr His Val Ile Pro Phe Phe Asp Glu Lys Glu Leu Gln Glu Arg
                1445                1450                1455    
 Lys Thr Glu Phe Glu Arg Ser His Asn Ile Arg Arg Phe Met Phe Glu
            1460                1465                1470        
 Met Pro Phe Thr Gln Thr Gly Lys Arg Gln Gly Gly Val Glu Glu Gln
        1475                1480                1485            
 Cys Lys Arg Arg Thr Ile Leu Thr Ala Ile His Cys Phe Pro Tyr Val
    1490                1495                1500                
 Lys Lys Arg Ile Pro Val Met Tyr Gln His His Thr Asp Leu Asn Pro
1505                1510                1515                1520
 Ile Glu Val Ala Ile Asp Glu Met Ser Lys Lys Val Ala Glu Leu Arg
                1525                1530                1535    
 Gln Leu Cys Ser Ser Ala Glu Val Asp Met Ile Lys Leu Gln Leu Lys
            1540                1545                1550        
 Leu Gln Gly Ser Val Ser Val Gln Val Asn Ala Gly Pro Leu Ala Tyr
        1555                1560                1565            
 Ala Arg Ala Phe Leu Asp Asp Thr Asn Thr Lys Arg Tyr Pro Asp Asn
    1570                1575                1580                
 Lys Val Lys Leu Leu Lys Glu Val Phe Arg Gln Phe Val Glu Ala Cys
1585                1590                1595                1600
 Gly Gln Ala Leu Ala Val Asn Glu Arg Leu Ile Lys Glu Asp Gln Leu
                1605                1610                1615    
 Glu Tyr Gln Glu Glu Met Lys Ala Asn Tyr Arg Glu Met Ala Lys Glu
            1620                1625                1630        
 Leu Ser Glu Ile Met His Glu Gln Leu Gly
        1635                1640        



      <210> 999
      <211> 290
      <212> PRT
      <213> Homo sapiens


      <400> 999
 Met Arg Met Glu Ala Gly Glu Ala Ala Pro Pro Ala Gly Ala Gly Gly
   1               5                  10                  15    
 Arg Ala Ala Gly Gly Trp Gly Lys Trp Val Arg Leu Asn Val Gly Gly
              20                  25                  30        
 Thr Val Phe Leu Thr Thr Arg Gln Thr Leu Cys Arg Glu Gln Lys Ser
          35                  40                  45            
 Phe Leu Ser Arg Leu Cys Gln Gly Glu Glu Leu Gln Ser Asp Arg Asp
      50                  55                  60                
 Glu Thr Gly Ala Tyr Leu Ile Asp Arg Asp Pro Thr Tyr Phe Gly Pro
  65                  70                  75                  80
 Ile Leu Asn Phe Leu Arg His Gly Lys Leu Val Leu Asp Lys Asp Met
                  85                  90                  95    
 Ala Glu Glu Gly Val Leu Glu Glu Ala Glu Phe Tyr Asn Ile Gly Pro
             100                 105                 110        
 Leu Ile Arg Ile Ile Lys Asp Arg Met Glu Glu Lys Asp Tyr Thr Val
         115                 120                 125            
 Thr Gln Val Pro Pro Lys His Val Tyr Arg Val Leu Gln Cys Gln Glu
     130                 135                 140                
 Glu Glu Leu Thr Gln Met Val Ser Thr Met Ser Asp Gly Trp Arg Phe
 145                 150                 155                 160
 Glu Gln Leu Val Asn Ile Gly Ser Ser Tyr Asn Tyr Gly Ser Glu Asp
                 165                 170                 175    
 Gln Ala Glu Phe Leu Cys Val Val Ser Lys Glu Leu His Ser Thr Pro
             180                 185                 190        
 Asn Gly Leu Ser Ser Glu Ser Ser Arg Lys Thr Lys Ser Thr Glu Glu
         195                 200                 205            
 Gln Leu Glu Glu Gln Gln Gln Gln Glu Glu Glu Val Glu Glu Val Glu
     210                 215                 220                
 Val Glu Gln Val Gln Val Glu Ala Asp Ala Gln Glu Lys Gly Ser Arg
 225                 230                 235                 240
 Pro His Pro Leu Arg Pro Glu Ala Glu Leu Ala Val Arg Ala Ser Pro
                 245                 250                 255    
 Arg Pro Leu Ala Arg Pro Gln Ser Cys His Pro Cys Cys Tyr Lys Pro
             260                 265                 270        
 Glu Ala Pro Gly Cys Glu Ala Pro Asp His Leu Gln Gly Leu Gly Val
         275                 280                 285            
 Pro Ile
     290



      <210> 1000
      <211> 723
      <212> PRT
      <213> Homo sapiens


      <400> 1000
 Met Ala Ala Ala Ala Thr Met Ala Ala Ala Ala Arg Glu Leu Val Leu
   1               5                  10                  15    
 Arg Ala Gly Thr Ser Asp Met Glu Glu Glu Glu Gly Pro Leu Ala Gly
              20                  25                  30        
 Gly Pro Gly Leu Gln Glu Pro Leu Gln Leu Gly Glu Leu Asp Ile Thr
          35                  40                  45            
 Ser Asp Glu Phe Ile Leu Asp Glu Val Asp Val His Ile Gln Ala Asn
      50                  55                  60                
 Leu Glu Asp Glu Leu Val Lys Glu Ala Leu Lys Thr Gly Val Asp Leu
  65                  70                  75                  80
 Arg His Tyr Ser Lys Gln Val Glu Leu Glu Leu Gln Gln Ile Glu Gln
                  85                  90                  95    
 Lys Ser Ile Arg Asp Tyr Ile Gln Glu Ser Glu Asn Ile Ala Ser Leu
             100                 105                 110        
 His Asn Gln Ile Thr Ala Cys Asp Ala Val Leu Glu Arg Met Glu Gln
         115                 120                 125            
 Met Leu Gly Ala Phe Gln Ser Asp Leu Ser Ser Ile Ser Ser Glu Ile
     130                 135                 140                
 Arg Thr Leu Gln Glu Gln Ser Gly Ala Met Asn Ile Arg Leu Arg Asn
 145                 150                 155                 160
 Arg Gln Ala Val Arg Gly Lys Leu Gly Glu Leu Val Asp Gly Leu Val
                 165                 170                 175    
 Val Pro Ser Ala Leu Val Thr Ala Ile Leu Glu Ala Pro Val Thr Glu
             180                 185                 190        
 Pro Arg Phe Leu Glu Gln Leu Gln Glu Leu Asp Ala Lys Ala Ala Ala
         195                 200                 205            
 Val Arg Glu Gln Glu Ala Arg Gly Thr Ala Ala Cys Ala Asp Val Arg
     210                 215                 220                
 Gly Val Leu Asp Arg Leu Arg Val Lys Ala Val Thr Lys Ile Arg Glu
 225                 230                 235                 240
 Phe Ile Leu Gln Lys Ile Tyr Ser Phe Arg Lys Pro Met Thr Asn Tyr
                 245                 250                 255    
 Gln Ile Pro Gln Thr Ala Leu Leu Lys Tyr Arg Phe Phe Tyr Gln Phe
             260                 265                 270        
 Leu Leu Gly Asn Glu Arg Ala Thr Ala Lys Glu Ile Arg Asp Glu Tyr
         275                 280                 285            
 Val Glu Thr Leu Ser Lys Ile Tyr Leu Ser Tyr Tyr Arg Ser Tyr Leu
     290                 295                 300                
 Gly Arg Leu Met Lys Val Gln Tyr Glu Glu Val Ala Glu Lys Asp Asp
 305                 310                 315                 320
 Leu Met Gly Val Glu Asp Thr Ala Lys Lys Gly Phe Phe Ser Lys Pro
                 325                 330                 335    
 Ser Leu Arg Ser Arg Asn Thr Ile Phe Thr Leu Gly Thr Arg Gly Ser
             340                 345                 350        
 Val Ile Ser Pro Thr Glu Leu Glu Ala Pro Ile Leu Val Pro His Thr
         355                 360                 365            
 Ala Gln Arg Gly Glu Gln Arg Tyr Pro Phe Glu Ala Leu Phe Arg Ser
     370                 375                 380                
 Gln His Tyr Ala Leu Leu Asp Asn Ser Cys Arg Glu Tyr Leu Phe Ile
 385                 390                 395                 400
 Cys Glu Phe Phe Val Val Ser Gly Pro Ala Ala His Asp Leu Phe His
                 405                 410                 415    
 Ala Val Met Gly Arg Thr Leu Ser Met Thr Leu Lys His Leu Asp Ser
             420                 425                 430        
 Tyr Leu Ala Asp Cys Tyr Asp Ala Ile Ala Val Phe Leu Cys Ile His
         435                 440                 445            
 Ile Val Leu Arg Phe Arg Asn Ile Ala Ala Lys Arg Asp Val Pro Ala
     450                 455                 460                
 Leu Asp Arg Tyr Trp Glu Gln Val Leu Ala Leu Leu Trp Pro Arg Phe
 465                 470                 475                 480
 Glu Leu Ile Leu Glu Met Asn Val Gln Ser Val Arg Ser Thr Asp Pro
                 485                 490                 495    
 Gln Arg Leu Gly Gly Leu Asp Thr Arg Pro His Tyr Ile Thr Arg Arg
             500                 505                 510        
 Tyr Ala Glu Phe Ser Ser Ala Leu Val Ser Ile Asn Gln Thr Ile Pro
         515                 520                 525            
 Asn Glu Arg Thr Met Gln Leu Leu Gly Gln Leu Gln Val Glu Val Glu
     530                 535                 540                
 Asn Phe Val Leu Arg Val Ala Ala Glu Phe Ser Ser Arg Lys Glu Gln
 545                 550                 555                 560
 Leu Val Phe Leu Ile Asn Asn Tyr Asp Met Met Leu Gly Val Leu Met
                 565                 570                 575    
 Glu Arg Ala Ala Asp Asp Ser Lys Glu Val Glu Ser Phe Gln Gln Leu
             580                 585                 590        
 Leu Asn Ala Arg Thr Gln Glu Phe Ile Glu Glu Leu Leu Ser Pro Pro
         595                 600                 605            
 Phe Gly Gly Leu Val Ala Phe Val Lys Glu Ala Glu Ala Leu Ile Glu
     610                 615                 620                
 Arg Gly Gln Ala Glu Arg Leu Arg Gly Glu Glu Ala Arg Val Thr Gln
 625                 630                 635                 640
 Leu Ile Arg Gly Phe Gly Ser Ser Trp Lys Ser Ser Val Glu Ser Leu
                 645                 650                 655    
 Ser Gln Asp Val Met Arg Ser Phe Thr Asn Phe Arg Asn Gly Thr Ser
             660                 665                 670        
 Ile Ile Gln Gly Ala Leu Thr Gln Leu Ile Gln Leu Tyr His Arg Phe
         675                 680                 685            
 His Arg Val Leu Ser Gln Pro Gln Leu Arg Ala Leu Pro Ala Arg Ala
     690                 695                 700                
 Glu Leu Ile Asn Ile His His Leu Met Val Glu Leu Lys Lys His Lys
 705                 710                 715                 720
 Pro Asn Phe
            



      <210> 1001
      <211> 1440
      <212> PRT
      <213> Homo sapiens


      <400> 1001
 Met Glu Cys Leu Asp Pro Pro Leu Gln Glu Val Pro Val Asp Glu Trp
   1               5                  10                  15    
 Phe Cys Pro Glu Cys Ala Ala Pro Gly Val Val Leu Ala Ala Asp Ala
              20                  25                  30        
 Gly Pro Val Ser Glu Glu Glu Val Ser Leu Leu Leu Ala Asp Val Val
          35                  40                  45            
 Pro Thr Thr Ser Arg Leu Arg Pro Arg Ala Gly Arg Thr Arg Ala Ile
      50                  55                  60                
 Ala Arg Thr Arg Gln Ser Glu Arg Val Arg Ala Thr Val Asn Arg Asn
  65                  70                  75                  80
 Arg Ile Ser Thr Ala Arg Arg Val Gln His Thr Pro Gly Arg Leu Gly
                  85                  90                  95    
 Ser Ser Leu Leu Asp Glu Ala Ile Glu Ala Val Ala Thr Gly Leu Ser
             100                 105                 110        
 Thr Ala Val Tyr Gln Arg Pro Leu Thr Pro Arg Thr Pro Ala Arg Arg
         115                 120                 125            
 Lys Arg Lys Thr Arg Arg Arg Lys Lys Val Pro Gly Arg Lys Lys Thr
     130                 135                 140                
 Pro Ser Gly Pro Ser Ala Lys Ser Lys Ser Ser Ala Thr Arg Ser Lys
 145                 150                 155                 160
 Lys Arg Gln His Arg Val Lys Lys Arg Arg Gly Lys Lys Val Lys Ser
                 165                 170                 175    
 Glu Ala Thr Thr Arg Ser Arg Ile Ala Arg Thr Leu Gly Leu Arg Arg
             180                 185                 190        
 Pro Val His Ser Ser Cys Ile Pro Ser Val Leu Lys Pro Val Glu Pro
         195                 200                 205            
 Ser Leu Gly Leu Leu Arg Ala Asp Ile Gly Ala Ala Ser Leu Ser Leu
     210                 215                 220                
 Phe Gly Asp Pro Tyr Glu Leu Asp Pro Phe Asp Ser Ser Glu Glu Leu
 225                 230                 235                 240
 Ser Ala Asn Pro Leu Ser Pro Leu Ser Ala Lys Arg Arg Ala Leu Ser
                 245                 250                 255    
 Arg Ser Ala Leu Gln Ser His Gln Pro Val Ala Arg Pro Val Ser Val
             260                 265                 270        
 Gly Leu Ser Arg Arg Arg Leu Pro Ala Ala Val Pro Glu Pro Asp Leu
         275                 280                 285            
 Glu Glu Glu Pro Val Pro Asp Leu Leu Gly Ser Ile Leu Ser Gly Gln
     290                 295                 300                
 Ser Pro Leu Met Leu Gly Ser Ser Asp Val Ile Ile His Arg Asp Gly
 305                 310                 315                 320
 Ser Leu Ser Ala Lys Arg Ala Ala Pro Val Ser Phe Gln Arg Asn Ser
                 325                 330                 335    
 Gly Ser Leu Ser Arg Gly Glu Glu Gly Phe Lys Gly Cys Leu Gln Pro
             340                 345                 350        
 Arg Ala Leu Pro Ser Gly Ser Pro Ala Gln Gly Pro Ser Gly Asn Arg
         355                 360                 365            
 Pro Gln Ser Thr Gly Leu Ser Cys Gln Gly Arg Ser Arg Thr Pro Ala
     370                 375                 380                
 Arg Thr Ala Gly Ala Pro Val Arg Leu Asp Leu Pro Ala Ala Pro Gly
 385                 390                 395                 400
 Ala Val Gln Ala Arg Asn Leu Ser Asn Gly Ser Val Pro Gly Phe Arg
                 405                 410                 415    
 Gln Ser His Ser Pro Trp Phe Asn Gly Thr Asn Lys His Thr Leu Pro
             420                 425                 430        
 Leu Ala Ser Ala Ala Ser Lys Ile Ser Ser Arg Asp Ser Lys Pro Pro
         435                 440                 445            
 Cys Arg Ser Val Val Pro Gly Pro Pro Leu Lys Pro Ala Pro Arg Arg
     450                 455                 460                
 Thr Asp Ile Ser Glu Leu Pro Arg Ile Pro Lys Ile Arg Arg Asp Asp
 465                 470                 475                 480
 Gly Gly Gly Arg Arg Asp Ala Ala Pro Ala His Gly Gln Ser Ile Glu
                 485                 490                 495    
 Ile Pro Ser Ala Cys Ile Ser Arg Leu Thr Gly Arg Glu Gly Thr Gly
             500                 505                 510        
 Gln Pro Gly Arg Gly Thr Arg Ala Glu Ser Glu Ala Ser Ser Arg Val
         515                 520                 525            
 Pro Arg Glu Pro Gly Val His Thr Gly Ser Ser Arg Pro Pro Ala Pro
     530                 535                 540                
 Ser Ser His Gly Ser Leu Ala Pro Leu Gly Pro Ser Arg Gly Lys Gly
 545                 550                 555                 560
 Val Gly Ser Thr Phe Glu Ser Phe Arg Ile Asn Ile Pro Gly Asn Met
                 565                 570                 575    
 Ala His Ser Ser Gln Leu Ser Ser Pro Gly Phe Cys Asn Thr Phe Arg
             580                 585                 590        
 Pro Val Asp Asp Lys Glu Gln Arg Lys Glu Asn Pro Ser Pro Leu Phe
         595                 600                 605            
 Ser Ile Lys Lys Thr Lys Gln Leu Arg Ser Glu Val Tyr Asp Pro Ser
     610                 615                 620                
 Asp Pro Thr Gly Ser Asp Ser Ser Ala Pro Gly Ser Ser Pro Glu Arg
 625                 630                 635                 640
 Ser Gly Pro Gly Leu Leu Pro Ser Glu Ile Thr Arg Thr Ile Ser Ile
                 645                 650                 655    
 Asn Ser Pro Lys Ala Gln Thr Val Gln Ala Val Arg Cys Val Thr Ser
             660                 665                 670        
 Tyr Thr Val Glu Ser Ile Phe Gly Thr Glu Pro Glu Pro Pro Leu Gly
         675                 680                 685            
 Pro Ser Ser Ala Met Ser Lys Leu Arg Gly Ala Val Ala Ala Glu Gly
     690                 695                 700                
 Ala Ser Asp Thr Glu Arg Glu Glu Pro Thr Glu Ser Gln Gly Leu Ala
 705                 710                 715                 720
 Ala Arg Leu Arg Arg Pro Ser Pro Pro Glu Pro Trp Asp Glu Glu Asp
                 725                 730                 735    
 Gly Ala Ser Cys Ser Thr Phe Phe Gly Ser Glu Glu Arg Thr Val Thr
             740                 745                 750        
 Cys Val Thr Val Val Glu Pro Glu Ala Pro Pro Ser Pro Asp Val Leu
         755                 760                 765            
 Gln Ala Ala Thr His Arg Val Val Glu Leu Arg Pro Pro Ser Arg Ser
     770                 775                 780                
 Arg Ser Thr Ser Ser Ser Arg Ser Arg Lys Lys Ala Lys Arg Lys Arg
 785                 790                 795                 800
 Val Ser Arg Glu His Gly Arg Thr Arg Ser Gly Thr Arg Ser Glu Ser
                 805                 810                 815    
 Arg Asp Arg Ser Ser Arg Ser Ala Ser Pro Ser Val Gly Glu Glu Arg
             820                 825                 830        
 Pro Arg Arg Gln Arg Ser Lys Ala Lys Ser Arg Arg Ser Ser Ser Asp
         835                 840                 845            
 Arg Ser Ser Ser Arg Glu Arg Ala Lys Arg Lys Lys Ala Lys Asp Lys
     850                 855                 860                
 Ser Arg Glu His Arg Arg Gly Pro Trp Gly His Ser Arg Arg Thr Ser
 865                 870                 875                 880
 Arg Ser Arg Ser Gly Ser Pro Gly Ser Ser Ser Tyr Glu His Tyr Glu
                 885                 890                 895    
 Ser Arg Lys Lys Lys Lys Arg Arg Ser Ala Ser Arg Pro Arg Gly Arg
             900                 905                 910        
 Glu Cys Ser Pro Thr Ser Ser Leu Glu Arg Leu Cys Arg His Lys His
         915                 920                 925            
 Gln Arg Glu Arg Ser His Glu Arg Pro Asp Arg Lys Glu Ser Val Ala
     930                 935                 940                
 Trp Pro Arg Asp Arg Arg Lys Arg Arg Ser Arg Ser Pro Ser Ser Glu
 945                 950                 955                 960
 His Arg Ala Arg Glu His Arg Arg Pro Arg Ser Arg Glu Lys Trp Pro
                 965                 970                 975    
 Gln Thr Arg Ser His Ser Pro Glu Arg Lys Gly Ala Val Arg Glu Ala
             980                 985                 990        
 Ser Pro Ala Pro Leu Ala Gln Gly Glu Pro Gly Arg Glu Asp Leu Pro
         995                1000                1005            
 Thr Arg Leu Pro Ala Leu Gly Glu Ala His Val Ser Pro Glu Val Ala
    1010                1015                1020                
 Thr Ala Asp Lys Ala Pro Leu Gln Ala Pro Pro Val Leu Glu Val Ala
1025                1030                1035                1040
 Ala Glu Cys Glu Pro Asp Asp Leu Asp Leu Asp Tyr Gly Asp Ser Val
                1045                1050                1055    
 Glu Ala Gly His Val Phe Asp Asp Phe Ser Ser Asp Ala Val Phe Ile
            1060                1065                1070        
 Gln Leu Asp Asp Met Ser Ser Pro Pro Ser Pro Glu Ser Thr Asp Ser
        1075                1080                1085            
 Ser Pro Glu Arg Asp Phe Pro Leu Lys Pro Ala Leu Pro Pro Ala Ser
    1090                1095                1100                
 Leu Ala Val Ala Ala Ile Gln Arg Glu Val Ser Leu Met His Asp Glu
1105                1110                1115                1120
 Asp Pro Ser Gln Pro Pro Pro Leu Pro Glu Gly Thr Gln Glu Pro His
                1125                1130                1135    
 Leu Leu Arg Pro Asp Ala Ala Glu Lys Ala Glu Ala Pro Ser Ser Pro
            1140                1145                1150        
 Asp Val Ala Pro Ala Gly Lys Glu Asp Ser Pro Ser Ala Ser Gly Arg
        1155                1160                1165            
 Val Gln Glu Ala Ala Arg Pro Glu Glu Val Val Ser Gln Thr Pro Leu
    1170                1175                1180                
 Leu Arg Ser Arg Ala Leu Val Lys Arg Val Thr Trp Asn Leu Gln Glu
1185                1190                1195                1200
 Ser Glu Ser Ser Ala Pro Ala Glu Asp Arg Ala Pro Arg Ala Pro Leu
                1205                1210                1215    
 His Arg Pro Gln Lys Pro Arg Glu Gly Ala Trp Asp Met Glu Asp Val
            1220                1225                1230        
 Ala Pro Thr Gly Val Arg Gln Ala Phe Ser Glu Leu Pro Phe Pro Ser
        1235                1240                1245            
 His Val Leu Pro Glu Pro Gly Phe Pro Asp Thr Asp Pro Ser Gln Val
    1250                1255                1260                
 Tyr Ser Pro Gly Leu Pro Pro Ala Pro Ala Gln Pro Ser Ser Ile Pro
1265                1270                1275                1280
 Pro Cys Ala Leu Val Ser Gln Pro Thr Val Gln Phe Ile Leu Gln Gly
                1285                1290                1295    
 Ser Leu Pro Leu Val Gly Cys Gly Ala Ala Gln Thr Leu Ala Pro Val
            1300                1305                1310        
 Pro Ala Ala Leu Thr Pro Ala Ser Glu Pro Ala Ser Gln Ala Thr Ala
        1315                1320                1325            
 Ala Ser Asn Ser Glu Glu Lys Thr Pro Ala Pro Arg Leu Ala Ala Glu
    1330                1335                1340                
 Lys Thr Lys Lys Glu Glu Tyr Met Lys Lys Leu His Met Gln Glu Arg
1345                1350                1355                1360
 Ala Val Glu Glu Val Lys Leu Ala Ile Lys Pro Phe Tyr Gln Lys Arg
                1365                1370                1375    
 Glu Val Thr Lys Glu Glu Tyr Lys Asp Ile Leu Arg Lys Ala Val Gln
            1380                1385                1390        
 Lys Ile Cys His Ser Lys Ser Gly Glu Ile Asn Pro Val Lys Val Ala
        1395                1400                1405            
 Asn Leu Val Lys Ala Tyr Val Asp Lys Tyr Arg His Met Arg Arg His
    1410                1415                1420                
 Lys Lys Pro Glu Ala Gly Glu Glu Pro Pro Thr Gln Gly Ala Glu Gly
1425                1430                1435                1440





      <210> 1002
      <211> 1649
      <212> PRT
      <213> Homo sapiens


      <400> 1002
 Met Asp Asp Asp Ser Leu Asp Glu Leu Val Ala Arg Ser Pro Gly Pro
   1               5                  10                  15    
 Asp Gly His Pro Gln Val Gly Pro Ala Asp Pro Ala Gly Asp Phe Glu
              20                  25                  30        
 Glu Ser Ser Val Gly Ser Ser Gly Asp Ser Gly Asp Asp Ser Asp Ser
          35                  40                  45            
 Glu His Gly Asp Gly Thr Asp Gly Glu Asp Glu Gly Ala Ser Glu Glu
      50                  55                  60                
 Glu Asp Leu Glu Asp Arg Ser Gly Ser Glu Asp Ser Glu Asp Asp Gly
  65                  70                  75                  80
 Glu Thr Leu Leu Glu Val Ala Gly Thr Gln Gly Lys Leu Glu Ala Ala
                  85                  90                  95    
 Gly Ser Phe Asn Ser Asp Asp Asp Ala Glu Ser Cys Pro Ile Cys Leu
             100                 105                 110        
 Asn Ala Phe Arg Asp Gln Ala Val Gly Thr Pro Glu Asn Cys Ala His
         115                 120                 125            
 Tyr Phe Cys Leu Asp Cys Ile Val Glu Trp Ser Lys Asn Ala Asn Ser
     130                 135                 140                
 Cys Pro Val Asp Arg Thr Leu Phe Lys Cys Ile Cys Ile Arg Ala Gln
 145                 150                 155                 160
 Phe Gly Gly Lys Ile Leu Arg Lys Ile Pro Val Glu Asn Thr Lys Ala
                 165                 170                 175    
 Ser Glu Glu Glu Glu Asp Pro Thr Phe Cys Glu Val Cys Gly Arg Ser
             180                 185                 190        
 Asp Arg Glu Asp Arg Leu Leu Leu Cys Asp Gly Cys Asp Ala Gly Tyr
         195                 200                 205            
 His Met Glu Cys Leu Asp Pro Pro Leu Gln Glu Val Pro Val Asp Glu
     210                 215                 220                
 Trp Phe Cys Pro Glu Cys Ala Ala Pro Gly Val Val Leu Ala Ala Asp
 225                 230                 235                 240
 Ala Gly Pro Val Ser Glu Glu Glu Val Ser Leu Leu Leu Ala Asp Val
                 245                 250                 255    
 Val Pro Thr Thr Ser Arg Leu Arg Pro Arg Ala Gly Arg Thr Arg Ala
             260                 265                 270        
 Ile Ala Arg Thr Arg Gln Ser Glu Arg Val Arg Ala Thr Val Asn Arg
         275                 280                 285            
 Asn Arg Ile Ser Thr Ala Arg Arg Val Gln His Thr Pro Gly Arg Leu
     290                 295                 300                
 Gly Ser Ser Leu Leu Asp Glu Ala Ile Glu Ala Val Ala Thr Gly Leu
 305                 310                 315                 320
 Ser Thr Ala Val Tyr Gln Arg Pro Leu Thr Pro Arg Thr Pro Ala Arg
                 325                 330                 335    
 Arg Lys Arg Lys Thr Arg Arg Arg Lys Lys Val Pro Gly Arg Lys Lys
             340                 345                 350        
 Thr Pro Ser Gly Pro Ser Ala Lys Ser Lys Ser Ser Ala Thr Arg Ser
         355                 360                 365            
 Lys Lys Arg Gln His Arg Val Lys Lys Arg Arg Gly Lys Lys Val Lys
     370                 375                 380                
 Ser Glu Ala Thr Thr Arg Ser Arg Ile Ala Arg Thr Leu Gly Leu Arg
 385                 390                 395                 400
 Arg Pro Val His Ser Ser Cys Ile Pro Ser Val Leu Lys Pro Val Glu
                 405                 410                 415    
 Pro Ser Leu Gly Leu Leu Arg Ala Asp Ile Gly Ala Ala Ser Leu Ser
             420                 425                 430        
 Leu Phe Gly Asp Pro Tyr Glu Leu Asp Pro Phe Asp Ser Ser Glu Glu
         435                 440                 445            
 Leu Ser Ala Asn Pro Leu Ser Pro Leu Ser Ala Lys Arg Arg Ala Leu
     450                 455                 460                
 Ser Arg Ser Ala Leu Gln Ser His Gln Pro Val Ala Arg Pro Val Ser
 465                 470                 475                 480
 Val Gly Leu Ser Arg Arg Arg Leu Pro Ala Ala Val Pro Glu Pro Asp
                 485                 490                 495    
 Leu Glu Glu Glu Pro Val Pro Asp Leu Leu Gly Ser Ile Leu Ser Gly
             500                 505                 510        
 Gln Ser Pro Leu Met Leu Gly Ser Ser Asp Val Ile Ile His Arg Asp
         515                 520                 525            
 Gly Ser Leu Ser Ala Lys Arg Ala Ala Pro Val Ser Phe Gln Arg Asn
     530                 535                 540                
 Ser Gly Ser Leu Ser Arg Gly Glu Glu Gly Phe Lys Gly Cys Leu Gln
 545                 550                 555                 560
 Pro Arg Ala Leu Pro Ser Gly Ser Pro Ala Gln Gly Pro Ser Gly Asn
                 565                 570                 575    
 Arg Pro Gln Ser Thr Gly Leu Ser Cys Gln Gly Arg Ser Arg Thr Pro
             580                 585                 590        
 Ala Arg Thr Ala Gly Ala Pro Val Arg Leu Asp Leu Pro Ala Ala Pro
         595                 600                 605            
 Gly Ala Val Gln Ala Arg Asn Leu Ser Asn Gly Ser Val Pro Gly Phe
     610                 615                 620                
 Arg Gln Ser His Ser Pro Trp Phe Asn Gly Thr Asn Lys His Thr Leu
 625                 630                 635                 640
 Pro Leu Ala Ser Ala Ala Ser Lys Ile Ser Ser Arg Asp Ser Lys Pro
                 645                 650                 655    
 Pro Cys Arg Ser Val Val Pro Gly Pro Pro Leu Lys Pro Ala Pro Arg
             660                 665                 670        
 Arg Thr Asp Ile Ser Glu Leu Pro Arg Ile Pro Lys Ile Arg Arg Asp
         675                 680                 685            
 Asp Gly Gly Gly Arg Arg Asp Ala Ala Pro Ala His Gly Gln Ser Ile
     690                 695                 700                
 Glu Ile Pro Ser Ala Cys Ile Ser Arg Leu Thr Gly Arg Glu Gly Thr
 705                 710                 715                 720
 Gly Gln Pro Gly Arg Gly Thr Arg Ala Glu Ser Glu Ala Ser Ser Arg
                 725                 730                 735    
 Val Pro Arg Glu Pro Gly Val His Thr Gly Ser Ser Arg Pro Pro Ala
             740                 745                 750        
 Pro Ser Ser His Gly Ser Leu Ala Pro Leu Gly Pro Ser Arg Gly Lys
         755                 760                 765            
 Gly Val Gly Ser Thr Phe Glu Ser Phe Arg Ile Asn Ile Pro Gly Asn
     770                 775                 780                
 Met Ala His Ser Ser Gln Leu Ser Ser Pro Gly Phe Cys Asn Thr Phe
 785                 790                 795                 800
 Arg Pro Val Asp Asp Lys Glu Gln Arg Lys Glu Asn Pro Ser Pro Leu
                 805                 810                 815    
 Phe Ser Ile Lys Lys Thr Lys Gln Leu Arg Ser Glu Val Tyr Asp Pro
             820                 825                 830        
 Ser Asp Pro Thr Gly Ser Asp Ser Ser Ala Pro Gly Ser Ser Pro Glu
         835                 840                 845            
 Arg Ser Gly Pro Gly Leu Leu Pro Ser Glu Ile Thr Arg Thr Ile Ser
     850                 855                 860                
 Ile Asn Ser Pro Lys Ala Gln Thr Val Gln Ala Val Arg Cys Val Thr
 865                 870                 875                 880
 Ser Tyr Thr Val Glu Ser Ile Phe Gly Thr Glu Pro Glu Pro Pro Leu
                 885                 890                 895    
 Gly Pro Ser Ser Ala Met Ser Lys Leu Arg Gly Ala Val Ala Ala Glu
             900                 905                 910        
 Gly Ala Ser Asp Thr Glu Arg Glu Glu Pro Thr Glu Ser Gln Gly Leu
         915                 920                 925            
 Ala Ala Arg Leu Arg Arg Pro Ser Pro Pro Glu Pro Trp Asp Glu Glu
     930                 935                 940                
 Asp Gly Ala Ser Cys Ser Thr Phe Phe Gly Ser Glu Glu Arg Thr Val
 945                 950                 955                 960
 Thr Cys Val Thr Val Val Glu Pro Glu Ala Pro Pro Ser Pro Asp Val
                 965                 970                 975    
 Leu Gln Ala Ala Thr His Arg Val Val Glu Leu Arg Pro Pro Ser Arg
             980                 985                 990        
 Ser Arg Ser Thr Ser Ser Ser Arg Ser Arg Lys Lys Ala Lys Arg Lys
         995                1000                1005            
 Arg Val Ser Arg Glu His Gly Arg Thr Arg Ser Gly Thr Arg Ser Glu
    1010                1015                1020                
 Ser Arg Asp Arg Ser Ser Arg Ser Ala Ser Pro Ser Val Gly Glu Glu
1025                1030                1035                1040
 Arg Pro Arg Arg Gln Arg Ser Lys Ala Lys Ser Arg Arg Ser Ser Ser
                1045                1050                1055    
 Asp Arg Ser Ser Ser Arg Glu Arg Ala Lys Arg Lys Lys Ala Lys Asp
            1060                1065                1070        
 Lys Ser Arg Glu His Arg Arg Gly Pro Trp Gly His Ser Arg Arg Thr
        1075                1080                1085            
 Ser Arg Ser Arg Ser Gly Ser Pro Gly Ser Ser Ser Tyr Glu His Tyr
    1090                1095                1100                
 Glu Ser Arg Lys Lys Lys Lys Arg Arg Ser Ala Ser Arg Pro Arg Gly
1105                1110                1115                1120
 Arg Glu Cys Ser Pro Thr Ser Ser Leu Glu Arg Leu Cys Arg His Lys
                1125                1130                1135    
 His Gln Arg Glu Arg Ser His Glu Arg Pro Asp Arg Lys Glu Ser Val
            1140                1145                1150        
 Ala Trp Pro Arg Asp Arg Arg Lys Arg Arg Ser Arg Ser Pro Ser Ser
        1155                1160                1165            
 Glu His Arg Ala Arg Glu His Arg Arg Pro Arg Ser Arg Glu Lys Trp
    1170                1175                1180                
 Pro Gln Thr Arg Ser His Ser Pro Glu Arg Lys Gly Ala Val Arg Glu
1185                1190                1195                1200
 Ala Ser Pro Ala Pro Leu Ala Gln Gly Glu Pro Gly Arg Glu Asp Leu
                1205                1210                1215    
 Pro Thr Arg Leu Pro Ala Leu Gly Glu Ala His Val Ser Pro Glu Val
            1220                1225                1230        
 Ala Thr Ala Asp Lys Ala Pro Leu Gln Ala Pro Pro Val Leu Glu Val
        1235                1240                1245            
 Ala Ala Glu Cys Glu Pro Asp Asp Leu Asp Leu Asp Tyr Gly Asp Ser
    1250                1255                1260                
 Val Glu Ala Gly His Val Phe Asp Asp Phe Ser Ser Asp Ala Val Phe
1265                1270                1275                1280
 Ile Gln Leu Asp Asp Met Ser Ser Pro Pro Ser Pro Glu Ser Thr Asp
                1285                1290                1295    
 Ser Ser Pro Glu Arg Asp Phe Pro Leu Lys Pro Ala Leu Pro Pro Ala
            1300                1305                1310        
 Ser Leu Ala Val Ala Ala Ile Gln Arg Glu Val Ser Leu Met His Asp
        1315                1320                1325            
 Glu Asp Pro Ser Gln Pro Pro Pro Leu Pro Glu Gly Thr Gln Glu Pro
    1330                1335                1340                
 His Leu Leu Arg Pro Asp Ala Ala Glu Lys Ala Glu Ala Pro Ser Ser
1345                1350                1355                1360
 Pro Asp Val Ala Pro Ala Gly Lys Glu Asp Ser Pro Ser Ala Ser Gly
                1365                1370                1375    
 Arg Val Gln Glu Ala Ala Arg Pro Glu Glu Val Val Ser Gln Thr Pro
            1380                1385                1390        
 Leu Leu Arg Ser Arg Ala Leu Val Lys Arg Val Thr Trp Asn Leu Gln
        1395                1400                1405            
 Glu Ser Glu Ser Ser Ala Pro Ala Glu Asp Arg Ala Pro Arg Ala Pro
    1410                1415                1420                
 Leu His Arg Pro Gln Lys Pro Arg Glu Gly Ala Trp Asp Met Glu Asp
1425                1430                1435                1440
 Val Ala Pro Thr Gly Val Arg Gln Ala Phe Ser Glu Leu Pro Phe Pro
                1445                1450                1455    
 Ser His Val Leu Pro Glu Pro Gly Phe Pro Asp Thr Asp Pro Ser Gln
            1460                1465                1470        
 Val Tyr Ser Pro Gly Leu Pro Pro Ala Pro Ala Gln Pro Ser Ser Ile
        1475                1480                1485            
 Pro Pro Cys Ala Leu Val Ser Gln Pro Thr Val Gln Phe Ile Leu Gln
    1490                1495                1500                
 Gly Ser Leu Pro Leu Val Gly Cys Gly Ala Ala Gln Thr Leu Ala Pro
1505                1510                1515                1520
 Val Pro Ala Ala Leu Thr Pro Ala Ser Glu Pro Ala Ser Gln Ala Thr
                1525                1530                1535    
 Ala Ala Ser Asn Ser Glu Glu Lys Thr Pro Ala Pro Arg Leu Ala Ala
            1540                1545                1550        
 Glu Lys Thr Lys Lys Glu Glu Tyr Met Lys Lys Leu His Met Gln Glu
        1555                1560                1565            
 Arg Ala Val Glu Glu Val Lys Leu Ala Ile Lys Pro Phe Tyr Gln Lys
    1570                1575                1580                
 Arg Glu Val Thr Lys Glu Glu Tyr Lys Asp Ile Leu Arg Lys Ala Val
1585                1590                1595                1600
 Gln Lys Ile Cys His Ser Lys Ser Gly Glu Ile Asn Pro Val Lys Val
                1605                1610                1615    
 Ala Asn Leu Val Lys Ala Tyr Val Asp Lys Tyr Arg His Met Arg Arg
            1620                1625                1630        
 His Lys Lys Pro Glu Ala Gly Glu Glu Pro Pro Thr Gln Gly Ala Glu
        1635                1640                1645            
 Gly
    



      <210> 1003
      <211> 1278
      <212> PRT
      <213> Homo sapiens


      <400> 1003
 Met Thr Leu Thr Glu Arg Leu Arg Glu Lys Ile Ser Arg Ala Phe Tyr
   1               5                  10                  15    
 Asn His Gly Leu Leu Cys Ala Ser Tyr Pro Ile Pro Ile Ile Leu Phe
              20                  25                  30        
 Thr Gly Phe Cys Ile Leu Ala Cys Cys Tyr Pro Leu Leu Lys Leu Pro
          35                  40                  45            
 Leu Pro Gly Thr Gly Pro Val Glu Phe Thr Thr Pro Val Lys Asp Tyr
      50                  55                  60                
 Ser Pro Pro Pro Val Asp Ser Asp Arg Lys Gln Gly Glu Pro Thr Glu
  65                  70                  75                  80
 Gln Pro Glu Trp Tyr Val Gly Ala Pro Val Ala Tyr Val Gln Gln Ile
                  85                  90                  95    
 Phe Val Lys Ser Ser Val Phe Pro Trp His Lys Asn Leu Leu Ala Val
             100                 105                 110        
 Asp Val Phe Arg Ser Pro Leu Ser Arg Ala Phe Gln Leu Val Glu Glu
         115                 120                 125            
 Ile Arg Asn His Val Leu Arg Asp Ser Ser Gly Ile Arg Ser Leu Glu
     130                 135                 140                
 Glu Leu Cys Leu Gln Val Thr Asp Leu Leu Pro Gly Leu Arg Lys Leu
 145                 150                 155                 160
 Arg Asn Leu Leu Pro Glu His Gly Cys Leu Leu Leu Ser Pro Gly Asn
                 165                 170                 175    
 Phe Trp Gln Asn Asp Trp Glu Arg Phe His Ala Asp Pro Asp Ile Ile
             180                 185                 190        
 Gly Thr Ile His Gln His Glu Pro Lys Thr Leu Gln Thr Ser Ala Thr
         195                 200                 205            
 Leu Lys Asp Leu Leu Phe Gly Val Pro Gly Lys Tyr Ser Gly Val Ser
     210                 215                 220                
 Leu Tyr Thr Arg Lys Arg Met Val Ser Tyr Thr Ile Thr Leu Val Phe
 225                 230                 235                 240
 Gln His Tyr His Ala Lys Phe Leu Gly Ser Leu Arg Ala Arg Leu Met
                 245                 250                 255    
 Leu Leu His Pro Ser Pro Asn Cys Ser Leu Arg Ala Glu Ser Leu Val
             260                 265                 270        
 His Val His Phe Lys Glu Glu Ile Gly Val Ala Glu Leu Ile Pro Leu
         275                 280                 285            
 Val Thr Thr Tyr Ile Ile Leu Phe Ala Tyr Ile Tyr Phe Ser Thr Arg
     290                 295                 300                
 Lys Ile Asp Met Val Lys Ser Lys Trp Gly Leu Ala Leu Ala Ala Val
 305                 310                 315                 320
 Val Thr Val Leu Ser Ser Leu Leu Met Ser Val Gly Leu Cys Thr Leu
                 325                 330                 335    
 Phe Gly Leu Thr Pro Thr Leu Asn Gly Gly Glu Ile Phe Pro Tyr Leu
             340                 345                 350        
 Val Val Val Ile Gly Leu Glu Asn Val Leu Val Leu Thr Lys Ser Val
         355                 360                 365            
 Val Ser Thr Pro Val Asp Leu Glu Val Lys Leu Arg Ile Ala Gln Gly
     370                 375                 380                
 Leu Ser Ser Glu Ser Trp Ser Ile Met Lys Asn Met Ala Thr Glu Leu
 385                 390                 395                 400
 Gly Ile Ile Leu Ile Gly Tyr Phe Thr Leu Val Pro Ala Ile Gln Glu
                 405                 410                 415    
 Phe Cys Leu Phe Ala Val Val Gly Leu Val Ser Asp Phe Phe Leu Gln
             420                 425                 430        
 Met Leu Phe Phe Thr Thr Val Leu Ser Ile Asp Ile Arg Arg Met Glu
         435                 440                 445            
 Leu Ala Asp Leu Asn Lys Arg Leu Pro Pro Glu Ala Cys Leu Pro Ser
     450                 455                 460                
 Ala Lys Pro Val Gly Gln Pro Thr Arg Tyr Glu Arg Gln Leu Ala Val
 465                 470                 475                 480
 Arg Pro Ser Thr Pro His Thr Ile Thr Leu Gln Pro Ser Ser Phe Arg
                 485                 490                 495    
 Asn Leu Arg Leu Pro Lys Arg Leu Arg Val Val Tyr Phe Leu Ala Arg
             500                 505                 510        
 Thr Arg Leu Ala Gln Arg Leu Ile Met Ala Gly Thr Val Val Trp Ile
         515                 520                 525            
 Gly Ile Leu Val Tyr Thr Asp Pro Ala Gly Leu Arg Asn Tyr Leu Ala
     530                 535                 540                
 Ala Gln Val Thr Glu Gln Ser Pro Leu Gly Glu Gly Ala Leu Ala Pro
 545                 550                 555                 560
 Met Pro Val Pro Ser Gly Met Leu Pro Pro Ser His Pro Asp Pro Ala
                 565                 570                 575    
 Phe Ser Ile Phe Pro Pro Asp Ala Pro Lys Leu Pro Glu Asn Gln Thr
             580                 585                 590        
 Ser Pro Gly Glu Ser Pro Glu Arg Gly Gly Pro Ala Glu Val Val His
         595                 600                 605            
 Asp Ser Pro Val Pro Glu Val Thr Trp Gly Pro Glu Asp Glu Glu Leu
     610                 615                 620                
 Trp Arg Lys Leu Ser Phe Arg His Trp Pro Thr Leu Phe Ser Tyr Tyr
 625                 630                 635                 640
 Asn Ile Thr Leu Ala Lys Arg Tyr Ile Ser Leu Leu Pro Val Ile Pro
                 645                 650                 655    
 Val Thr Leu Arg Leu Asn Pro Arg Glu Ala Leu Glu Gly Arg His Pro
             660                 665                 670        
 Gln Asp Gly Arg Ser Ala Trp Pro Pro Pro Gly Pro Ile Pro Ala Gly
         675                 680                 685            
 His Trp Glu Ala Gly Pro Lys Gly Pro Gly Gly Val Gln Ala His Gly
     690                 695                 700                
 Asp Val Thr Leu Tyr Lys Val Ala Ala Leu Gly Leu Ala Thr Gly Ile
 705                 710                 715                 720
 Val Leu Val Leu Leu Leu Leu Cys Leu Tyr Arg Val Leu Cys Pro Arg
                 725                 730                 735    
 Asn Tyr Gly Gln Leu Gly Gly Gly Pro Gly Arg Arg Arg Arg Gly Glu
             740                 745                 750        
 Leu Pro Cys Asp Asp Tyr Gly Tyr Ala Pro Pro Glu Thr Glu Ile Val
         755                 760                 765            
 Pro Leu Val Leu Arg Gly His Leu Met Asp Ile Glu Cys Leu Ala Ser
     770                 775                 780                
 Asp Gly Met Leu Leu Val Ser Cys Cys Leu Ala Gly His Val Cys Val
 785                 790                 795                 800
 Trp Asp Ala Gln Thr Gly Asp Cys Leu Thr Arg Ile Pro Arg Pro Gly
                 805                 810                 815    
 Gln Arg Arg Asp Ser Gly Val Gly Ser Gly Leu Glu Ala Gln Glu Ser
             820                 825                 830        
 Trp Glu Arg Leu Ser Asp Gly Gly Lys Ala Gly Pro Glu Glu Pro Gly
         835                 840                 845            
 Asp Ser Pro Pro Leu Arg His Arg Pro Arg Gly Pro Pro Pro Pro Ser
     850                 855                 860                
 Leu Phe Gly Asp Gln Pro Asp Leu Thr Cys Leu Ile Asp Thr Asn Phe
 865                 870                 875                 880
 Ser Ala Gln Pro Arg Ser Ser Gln Pro Thr Gln Pro Glu Pro Arg His
                 885                 890                 895    
 Arg Ala Val Cys Gly Arg Ser Arg Asp Ser Pro Gly Tyr Asp Phe Ser
             900                 905                 910        
 Cys Leu Val Gln Arg Val Tyr Gln Glu Glu Gly Leu Ala Ala Val Cys
         915                 920                 925            
 Thr Pro Ala Leu Arg Pro Pro Ser Pro Gly Pro Val Leu Ser Gln Ala
     930                 935                 940                
 Pro Glu Asp Glu Gly Gly Ser Pro Glu Lys Gly Ser Pro Ser Leu Ala
 945                 950                 955                 960
 Trp Ala Pro Ser Ala Glu Gly Ser Ile Trp Ser Leu Glu Leu Gln Gly
                 965                 970                 975    
 Asn Leu Ile Val Val Gly Arg Ser Ser Gly Arg Leu Glu Val Trp Asp
             980                 985                 990        
 Ala Ile Glu Gly Val Leu Cys Cys Ser Ser Glu Glu Val Ser Ser Gly
         995                1000                1005            
 Ile Thr Ala Leu Val Phe Leu Asp Lys Arg Ile Val Ala Ala Arg Leu
    1010                1015                1020                
 Asn Gly Ser Leu Asp Phe Phe Ser Leu Glu Thr His Thr Ala Leu Ser
1025                1030                1035                1040
 Pro Leu Gln Phe Arg Gly Thr Pro Gly Arg Gly Ser Ser Pro Ala Ser
                1045                1050                1055    
 Pro Val Tyr Ser Ser Ser Asp Thr Val Ala Cys His Leu Thr His Thr
            1060                1065                1070        
 Val Pro Cys Ala His Gln Lys Pro Ile Thr Ala Leu Lys Ala Ala Ala
        1075                1080                1085            
 Gly Arg Leu Val Thr Gly Ser Gln Asp His Thr Leu Arg Val Phe Arg
    1090                1095                1100                
 Leu Glu Asp Ser Cys Cys Leu Phe Thr Leu Gln Gly His Ser Gly Ala
1105                1110                1115                1120
 Ile Thr Thr Val Tyr Ile Asp Gln Thr Met Val Leu Ala Ser Gly Gly
                1125                1130                1135    
 Gln Asp Gly Ala Ile Cys Leu Trp Asp Val Leu Thr Gly Ser Arg Val
            1140                1145                1150        
 Ser His Val Phe Ala His Arg Gly Asp Val Thr Ser Leu Thr Cys Thr
        1155                1160                1165            
 Thr Ser Cys Val Ile Ser Ser Gly Leu Asp Asp Leu Ile Ser Ile Trp
    1170                1175                1180                
 Asp Arg Ser Thr Gly Ile Lys Phe Tyr Ser Ile Gln Gln Asp Leu Gly
1185                1190                1195                1200
 Cys Gly Ala Ser Leu Gly Val Ile Ser Asn Asn Leu Leu Val Thr Gly
                1205                1210                1215    
 Gly Gln Gly Cys Val Ser Phe Trp Asp Leu Asn Tyr Gly Asp Leu Leu
            1220                1225                1230        
 Gln Thr Val Tyr Leu Gly Lys Asn Ser Glu Ala Gln Pro Ala Arg Gln
        1235                1240                1245            
 Ile Leu Val Leu Asp Asn Ala Ala Ile Val Cys Asn Phe Gly Ser Glu
    1250                1255                1260                
 Leu Ser Leu Val Tyr Val Pro Ser Val Leu Glu Lys Leu Asp
1265                1270                1275            



      <210> 1004
      <211> 381
      <212> PRT
      <213> Homo sapiens


      <400> 1004
 Met Ser Arg His Glu Gly Val Ser Cys Asp Ala Cys Leu Lys Gly Asn
   1               5                  10                  15    
 Phe Arg Gly Arg Arg Tyr Lys Cys Leu Ile Cys Tyr Asp Tyr Asp Leu
              20                  25                  30        
 Cys Ala Ser Cys Tyr Glu Ser Gly Ala Thr Thr Thr Arg His Thr Thr
          35                  40                  45            
 Asp His Pro Met Gln Cys Ile Leu Thr Arg Val Asp Phe Asp Leu Tyr
      50                  55                  60                
 Tyr Gly Gly Glu Ala Phe Ser Val Glu Gln Pro Gln Ser Phe Thr Cys
  65                  70                  75                  80
 Pro Tyr Cys Gly Lys Met Gly Tyr Thr Glu Thr Ser Leu Gln Glu His
                  85                  90                  95    
 Val Thr Ser Glu His Ala Glu Thr Ser Thr Glu Val Ile Cys Pro Ile
             100                 105                 110        
 Cys Ala Ala Leu Pro Gly Gly Asp Pro Asn His Val Thr Asp Asp Phe
         115                 120                 125            
 Ala Ala His Leu Thr Leu Glu His Arg Ala Pro Arg Asp Leu Asp Glu
     130                 135                 140                
 Ser Ser Gly Val Arg His Val Arg Arg Met Phe His Pro Gly Arg Gly
 145                 150                 155                 160
 Leu Gly Gly Pro Arg Ala Arg Arg Ser Asn Met His Phe Thr Ser Ser
                 165                 170                 175    
 Ser Thr Gly Gly Leu Ser Ser Ser Gln Ser Ser Tyr Ser Pro Ser Asn
             180                 185                 190        
 Arg Glu Ala Met Asp Pro Ile Ala Glu Leu Leu Ser Gln Leu Ser Gly
         195                 200                 205            
 Val Arg Arg Ser Ala Gly Gly Gln Leu Asn Ser Ser Gly Pro Ser Ala
     210                 215                 220                
 Ser Gln Leu Gln Gln Leu Gln Met Gln Leu Gln Leu Glu Arg Gln His
 225                 230                 235                 240
 Ala Gln Ala Ala Arg Gln Gln Leu Glu Thr Ala Arg Asn Ala Thr Arg
                 245                 250                 255    
 Arg Thr Asn Thr Ser Ser Val Thr Thr Thr Ile Thr Gln Ser Thr Ala
             260                 265                 270        
 Thr Thr Asn Ile Ala Asn Thr Glu Ser Ser Gln Gln Thr Leu Gln Asn
         275                 280                 285            
 Ser Gln Phe Leu Leu Thr Arg Leu Asn Asp Pro Lys Met Ser Glu Thr
     290                 295                 300                
 Glu Arg Gln Ser Met Glu Ser Glu Arg Ala Asp Arg Ser Leu Phe Val
 305                 310                 315                 320
 Gln Glu Leu Leu Leu Ser Thr Leu Val Arg Glu Glu Ser Ser Ser Ser
                 325                 330                 335    
 Asp Glu Asp Asp Arg Gly Glu Met Ala Asp Phe Gly Ala Met Gly Cys
             340                 345                 350        
 Val Asp Ile Met Pro Leu Asp Val Ala Leu Glu Asn Leu Asn Leu Lys
         355                 360                 365            
 Glu Ser Asn Lys Gly Asn Glu Pro Pro Pro Pro Pro Leu
     370                 375                 380    



      <210> 1005
      <211> 195
      <212> PRT
      <213> Homo sapiens


      <400> 1005
 Met Asn Pro Val Tyr Ser Pro Gly Ser Ser Gly Val Pro Tyr Ala Asn
   1               5                  10                  15    
 Ala Lys Gly Ile Gly Tyr Pro Ala Gly Phe Pro Met Gly Tyr Ala Ala
              20                  25                  30        
 Ala Ala Pro Ala Tyr Ser Pro Asn Met Tyr Pro Gly Ala Asn Pro Thr
          35                  40                  45            
 Phe Gln Thr Gly Tyr Thr Pro Gly Thr Pro Tyr Lys Val Ser Cys Ser
      50                  55                  60                
 Pro Thr Ser Gly Ala Val Pro Pro Tyr Ser Ser Ser Pro Asn Pro Tyr
  65                  70                  75                  80
 Gln Thr Ala Val Tyr Pro Val Arg Ser Ala Tyr Pro Gln Gln Ser Pro
                  85                  90                  95    
 Tyr Ala Gln Gln Gly Thr Tyr Tyr Thr Gln Pro Leu Tyr Ala Ala Pro
             100                 105                 110        
 Pro His Val Ile His His Thr Thr Val Val Gln Pro Asn Gly Met Pro
         115                 120                 125            
 Ala Thr Val Tyr Pro Ala Pro Ile Pro Pro Pro Arg Gly Asn Gly Val
     130                 135                 140                
 Thr Met Gly Met Val Ala Gly Thr Thr Met Ala Met Ser Ala Gly Thr
 145                 150                 155                 160
 Leu Leu Thr Ala His Ser Pro Thr Pro Val Ala Pro His Pro Val Thr
                 165                 170                 175    
 Val Pro Thr Tyr Arg Ala Pro Gly Thr Pro Thr Tyr Ser Tyr Val Pro
             180                 185                 190        
 Pro Gln Trp
         195



      <210> 1006
      <211> 426
      <212> PRT
      <213> Homo sapiens


      <400> 1006
 Met Val Leu Ser Val Pro Val Ile Ala Leu Gly Ala Thr Leu Gly Thr
   1               5                  10                  15    
 Ala Thr Ser Ile Leu Ala Leu Cys Gly Val Thr Cys Leu Cys Arg His
              20                  25                  30        
 Met His Pro Lys Lys Gly Leu Leu Pro Arg Asp Gln Asp Pro Asp Leu
          35                  40                  45            
 Glu Lys Ala Lys Pro Ser Leu Leu Gly Ser Ala Gln Gln Phe Asn Val
      50                  55                  60                
 Lys Lys Ser Thr Glu Pro Val Gln Pro Arg Ala Leu Leu Lys Phe Pro
  65                  70                  75                  80
 Asp Ile Tyr Gly Pro Arg Pro Ala Val Thr Ala Pro Glu Val Ile Asn
                  85                  90                  95    
 Tyr Ala Asp Tyr Ser Leu Arg Ser Thr Glu Glu Pro Thr Ala Pro Ala
             100                 105                 110        
 Ser Pro Gln Pro Pro Asn Asp Ser Arg Leu Lys Arg Gln Val Thr Glu
         115                 120                 125            
 Glu Leu Phe Ile Leu Pro Gln Asn Gly Val Val Glu Asp Val Cys Val
     130                 135                 140                
 Met Glu Thr Trp Asn Pro Glu Lys Ala Ala Ser Trp Asn Gln Ala Pro
 145                 150                 155                 160
 Lys Leu His Tyr Cys Leu Asp Tyr Asp Cys Gln Lys Ala Glu Leu Phe
                 165                 170                 175    
 Val Thr Arg Leu Glu Ala Val Thr Ser Asn His Asp Gly Gly Cys Asp
             180                 185                 190        
 Cys Tyr Val Gln Gly Ser Val Ala Asn Arg Thr Gly Ser Val Glu Ala
         195                 200                 205            
 Gln Thr Ala Leu Lys Lys Arg Gln Leu His Thr Thr Trp Glu Glu Gly
     210                 215                 220                
 Leu Val Leu Pro Leu Ala Glu Glu Glu Leu Pro Thr Ala Thr Leu Thr
 225                 230                 235                 240
 Leu Thr Leu Arg Thr Cys Asp Arg Phe Ser Arg His Ser Val Ala Gly
                 245                 250                 255    
 Glu Leu Arg Leu Gly Leu Asp Gly Thr Ser Val Pro Leu Gly Ala Ala
             260                 265                 270        
 Gln Trp Gly Glu Leu Lys Thr Ser Ala Lys Glu Pro Ser Ala Gly Ala
         275                 280                 285            
 Gly Glu Val Leu Leu Ser Ile Ser Tyr Leu Pro Ala Ala Asn Arg Leu
     290                 295                 300                
 Leu Val Val Leu Ile Lys Ala Lys Asn Leu His Ser Asn Gln Ser Lys
 305                 310                 315                 320
 Glu Leu Leu Gly Lys Asp Val Ser Val Lys Val Thr Leu Lys His Gln
                 325                 330                 335    
 Ala Arg Lys Leu Lys Lys Lys Gln Thr Lys Arg Ala Lys His Lys Ile
             340                 345                 350        
 Asn Pro Val Trp Asn Glu Met Ile Met Phe Glu Leu Pro Asp Asp Leu
         355                 360                 365            
 Leu Gln Ala Ser Ser Val Glu Leu Glu Val Leu Gly Gln Asp Asp Ser
     370                 375                 380                
 Gly Gln Ser Cys Ala Leu Gly His Cys Ser Leu Gly Leu His Thr Ser
 385                 390                 395                 400
 Gly Ser Glu Arg Ser His Trp Glu Glu Met Leu Lys Asn Pro Arg Arg
                 405                 410                 415    
 Gln Ile Ala Met Trp His Gln Leu His Leu
             420                 425    



      <210> 1007
      <211> 1038
      <212> PRT
      <213> Homo sapiens


      <400> 1007
 Met Asp Pro Asn Thr Ile Ile Glu Ala Leu Arg Gly Thr Met Asp Pro
   1               5                  10                  15    
 Ala Leu Arg Glu Ala Ala Glu Arg Gln Leu Asn Glu Ala His Lys Ser
              20                  25                  30        
 Leu Asn Phe Val Ser Thr Leu Leu Gln Ile Thr Met Ser Glu Gln Leu
          35                  40                  45            
 Asp Leu Pro Val Arg Gln Ala Gly Val Ile Tyr Leu Lys Asn Met Ile
      50                  55                  60                
 Thr Gln Tyr Trp Pro Asp Arg Glu Thr Ala Pro Gly Asp Ile Ser Pro
  65                  70                  75                  80
 Tyr Thr Ile Pro Glu Glu Asp Arg His Cys Ile Arg Glu Asn Ile Val
                  85                  90                  95    
 Glu Ala Ile Ile His Ser Pro Glu Leu Ile Arg Val Gln Leu Thr Thr
             100                 105                 110        
 Cys Ile His His Ile Ile Lys His Asp Tyr Pro Ser Arg Trp Thr Ala
         115                 120                 125            
 Ile Val Asp Lys Ile Gly Phe Tyr Leu Gln Ser Asp Asn Ser Ala Cys
     130                 135                 140                
 Trp Leu Gly Ile Leu Leu Cys Leu Tyr Gln Leu Val Lys Asn Tyr Glu
 145                 150                 155                 160
 Tyr Lys Lys Pro Glu Glu Arg Ser Pro Leu Val Ala Ala Met Gln His
                 165                 170                 175    
 Phe Leu Pro Val Leu Lys Asp Arg Phe Ile Gln Leu Leu Ser Asp Gln
             180                 185                 190        
 Ser Asp Gln Ser Val Leu Ile Gln Lys Gln Ile Phe Lys Ile Phe Tyr
         195                 200                 205            
 Ala Leu Val Gln Tyr Thr Leu Pro Leu Glu Leu Ile Asn Gln Gln Asn
     210                 215                 220                
 Leu Thr Glu Trp Ile Glu Ile Leu Lys Thr Val Val Asn Arg Asp Val
 225                 230                 235                 240
 Pro Asn Glu Thr Leu Gln Val Glu Glu Asp Asp Arg Pro Glu Leu Pro
                 245                 250                 255    
 Trp Trp Lys Cys Lys Lys Trp Ala Leu His Ile Leu Ala Arg Leu Phe
             260                 265                 270        
 Glu Arg Tyr Gly Ser Pro Gly Asn Val Ser Lys Glu Tyr Asn Glu Phe
         275                 280                 285            
 Ala Glu Val Phe Leu Lys Ala Phe Ala Val Gly Val Gln Gln Val Leu
     290                 295                 300                
 Leu Lys Val Leu Tyr Gln Tyr Lys Glu Lys Gln Tyr Met Ala Pro Arg
 305                 310                 315                 320
 Val Leu Gln Gln Thr Leu Asn Tyr Ile Asn Gln Gly Val Ser His Ala
                 325                 330                 335    
 Leu Thr Trp Lys Asn Leu Lys Pro His Ile Gln Gly Ile Ile Gln Asp
             340                 345                 350        
 Val Ile Phe Pro Leu Met Cys Tyr Thr Asp Ala Asp Glu Glu Leu Trp
         355                 360                 365            
 Gln Glu Asp Pro Tyr Glu Tyr Ile Arg Met Lys Phe Asp Val Phe Glu
     370                 375                 380                
 Asp Phe Ile Ser Pro Thr Thr Ala Ala Gln Thr Leu Leu Phe Thr Ala
 385                 390                 395                 400
 Cys Ser Lys Arg Lys Glu Val Leu Gln Lys Thr Met Gly Phe Cys Tyr
                 405                 410                 415    
 Gln Ile Leu Thr Glu Pro Asn Ala Asp Pro Arg Lys Lys Asp Gly Ala
             420                 425                 430        
 Leu His Met Ile Gly Ser Leu Ala Glu Ile Leu Leu Lys Lys Lys Ile
         435                 440                 445            
 Tyr Lys Asp Gln Met Glu Tyr Met Leu Gln Asn His Val Phe Pro Leu
     450                 455                 460                
 Phe Ser Ser Glu Leu Gly Tyr Met Arg Ala Arg Ala Cys Trp Val Leu
 465                 470                 475                 480
 His Tyr Phe Cys Glu Val Lys Phe Lys Ser Asp Gln Asn Leu Gln Thr
                 485                 490                 495    
 Ala Leu Glu Leu Thr Arg Arg Cys Leu Ile Asp Asp Arg Glu Met Pro
             500                 505                 510        
 Val Lys Val Glu Ala Ala Ile Ala Leu Gln Val Leu Ile Ser Asn Gln
         515                 520                 525            
 Glu Lys Ala Lys Glu Tyr Ile Thr Pro Phe Ile Arg Pro Val Met Gln
     530                 535                 540                
 Ala Leu Leu His Ile Ile Arg Glu Thr Glu Asn Asp Asp Leu Thr Asn
 545                 550                 555                 560
 Val Ile Gln Lys Met Ile Cys Glu Tyr Ser Glu Glu Val Thr Pro Ile
                 565                 570                 575    
 Ala Val Glu Met Thr Gln His Leu Ala Met Thr Phe Asn Gln Val Ile
             580                 585                 590        
 Gln Thr Gly Pro Asp Glu Glu Gly Ser Asp Asp Lys Ala Val Thr Ala
         595                 600                 605            
 Met Gly Ile Leu Asn Thr Ile Asp Thr Leu Leu Ser Val Val Glu Asp
     610                 615                 620                
 His Lys Glu Ile Thr Gln Gln Leu Glu Gly Ile Cys Leu Gln Val Ile
 625                 630                 635                 640
 Gly Thr Val Leu Gln Gln His Val Leu Glu Phe Tyr Glu Glu Ile Phe
                 645                 650                 655    
 Ser Leu Ala His Ser Leu Thr Cys Gln Gln Val Ser Pro Gln Met Trp
             660                 665                 670        
 Gln Leu Leu Pro Leu Val Phe Glu Val Phe Gln Gln Asp Gly Phe Asp
         675                 680                 685            
 Tyr Phe Thr Asp Met Met Pro Leu Leu His Asn Tyr Val Thr Val Asp
     690                 695                 700                
 Thr Asp Thr Leu Leu Ser Asp Thr Lys Tyr Leu Glu Met Ile Tyr Ser
 705                 710                 715                 720
 Met Cys Lys Lys Val Leu Thr Gly Val Ala Gly Glu Asp Ala Glu Cys
                 725                 730                 735    
 His Ala Ala Lys Leu Leu Glu Val Ile Ile Leu Gln Cys Lys Gly Arg
             740                 745                 750        
 Gly Ile Asp Gln Cys Ile Pro Leu Phe Val Glu Ala Ala Leu Glu Arg
         755                 760                 765            
 Leu Thr Arg Glu Val Lys Thr Ser Glu Leu Arg Thr Met Cys Leu Gln
     770                 775                 780                
 Val Ala Ile Ala Ala Leu Tyr Tyr Asn Pro His Leu Leu Leu Asn Thr
 785                 790                 795                 800
 Leu Glu Asn Leu Arg Phe Pro Asn Asn Val Glu Pro Val Thr Asn His
                 805                 810                 815    
 Phe Ile Thr Gln Trp Leu Asn Asp Val Asp Cys Phe Leu Gly Leu His
             820                 825                 830        
 Asp Arg Lys Met Cys Val Leu Gly Leu Cys Ala Leu Ile Asp Met Glu
         835                 840                 845            
 Gln Ile Pro Gln Val Leu Asn Gln Val Ser Gly Gln Ile Leu Pro Ala
     850                 855                 860                
 Phe Ile Leu Leu Phe Asn Gly Leu Lys Arg Ala Tyr Ala Cys His Ala
 865                 870                 875                 880
 Glu His Glu Asn Asp Ser Asp Asp Asp Asp Glu Ala Glu Asp Asp Asp
                 885                 890                 895    
 Glu Thr Glu Glu Leu Gly Ser Asp Glu Asp Asp Ile Asp Glu Asp Gly
             900                 905                 910        
 Gln Glu Tyr Leu Glu Ile Leu Ala Lys Gln Ala Gly Glu Asp Gly Asp
         915                 920                 925            
 Asp Glu Asp Trp Glu Glu Asp Asp Ala Glu Glu Thr Ala Leu Glu Gly
     930                 935                 940                
 Tyr Ser Thr Ile Ile Asp Asp Glu Asp Asn Pro Val Asp Glu Tyr Gln
 945                 950                 955                 960
 Ile Phe Lys Ala Ile Phe Gln Thr Ile Gln Asn Arg Asn Pro Val Trp
                 965                 970                 975    
 Tyr Gln Ala Leu Thr His Gly Leu Asn Glu Glu Gln Arg Lys Gln Leu
             980                 985                 990        
 Gln Asp Ile Ala Thr Leu Ala Asp Gln Arg Arg Ala Ala His Glu Ser
         995                1000                1005            
 Lys Met Ile Glu Lys His Gly Gly Tyr Lys Phe Ser Ala Pro Val Val
    1010                1015                1020                
 Pro Ser Ser Phe Asn Phe Gly Gly Pro Ala Pro Gly Met Asn
1025                1030                1035            



      <210> 1008
      <211> 717
      <212> PRT
      <213> Homo sapiens


      <400> 1008
 Met Ser Trp Glu Ser Gly Ala Gly Pro Gly Leu Gly Ser Gln Gly Met
   1               5                  10                  15    
 Asp Leu Val Trp Ser Ala Trp Tyr Gly Lys Cys Val Lys Gly Lys Gly
              20                  25                  30        
 Ser Leu Pro Leu Ser Ala His Gly Ile Val Val Ala Trp Leu Ser Arg
          35                  40                  45            
 Ala Glu Trp Asp Gln Val Thr Val Tyr Leu Phe Cys Asp Asp His Lys
      50                  55                  60                
 Leu Gln Arg Tyr Ala Leu Asn Arg Ile Thr Val Trp Arg Ser Arg Ser
  65                  70                  75                  80
 Gly Asn Glu Leu Pro Leu Ala Val Ala Ser Thr Ala Asp Leu Ile Arg
                  85                  90                  95    
 Cys Lys Leu Leu Asp Val Thr Gly Gly Leu Gly Thr Asp Glu Leu Arg
             100                 105                 110        
 Leu Leu Tyr Gly Met Ala Leu Val Arg Phe Val Asn Leu Ile Ser Glu
         115                 120                 125            
 Arg Lys Thr Lys Phe Ala Lys Val Pro Leu Lys Cys Leu Ala Gln Glu
     130                 135                 140                
 Val Asn Ile Pro Asp Trp Ile Val Asp Leu Arg His Glu Leu Thr His
 145                 150                 155                 160
 Lys Lys Met Pro His Ile Asn Asp Cys Arg Arg Gly Cys Tyr Phe Val
                 165                 170                 175    
 Leu Asp Trp Leu Gln Lys Thr Tyr Trp Cys Arg Gln Leu Glu Asn Ser
             180                 185                 190        
 Leu Arg Glu Thr Trp Glu Leu Glu Glu Phe Arg Glu Gly Ile Glu Glu
         195                 200                 205            
 Glu Asp Gln Glu Glu Asp Lys Asn Ile Val Val Asp Asp Ile Thr Glu
     210                 215                 220                
 Gln Lys Pro Glu Pro Gln Asp Asp Gly Lys Ser Thr Glu Ser Asp Val
 225                 230                 235                 240
 Lys Ala Asp Gly Asp Ser Lys Gly Ser Glu Glu Val Asp Ser His Cys
                 245                 250                 255    
 Lys Lys Ala Leu Ser His Lys Glu Leu Tyr Glu Arg Ala Arg Glu Leu
             260                 265                 270        
 Leu Val Ser Tyr Glu Glu Glu Gln Phe Thr Val Leu Glu Lys Phe Arg
         275                 280                 285            
 Tyr Leu Pro Lys Ala Ile Lys Ala Trp Asn Asn Pro Ser Pro Arg Val
     290                 295                 300                
 Glu Cys Val Leu Ala Glu Leu Lys Gly Val Thr Cys Glu Asn Arg Glu
 305                 310                 315                 320
 Ala Val Leu Asp Ala Phe Leu Asp Asp Gly Phe Leu Val Pro Thr Phe
                 325                 330                 335    
 Glu Gln Leu Ala Ala Leu Gln Ile Glu Tyr Glu Glu Asn Val Asp Leu
             340                 345                 350        
 Asn Asp Val Leu Val Pro Lys Pro Phe Ser Gln Phe Trp Gln Pro Leu
         355                 360                 365            
 Leu Arg Gly Leu His Ser Gln Asn Phe Thr Gln Ala Leu Leu Glu Arg
     370                 375                 380                
 Met Leu Ser Glu Leu Pro Ala Leu Gly Ile Ser Gly Ile Arg Pro Thr
 385                 390                 395                 400
 Tyr Ile Leu Arg Trp Thr Val Glu Leu Ile Val Ala Asn Thr Lys Thr
                 405                 410                 415    
 Gly Arg Asn Ala Arg Arg Phe Ser Ala Gly Gln Trp Glu Ala Arg Arg
             420                 425                 430        
 Gly Trp Arg Leu Phe Asn Cys Ser Ala Ser Leu Asp Trp Pro Arg Met
         435                 440                 445            
 Val Glu Ser Cys Leu Gly Ser Pro Cys Trp Ala Ser Pro Gln Leu Leu
     450                 455                 460                
 Arg Ile Ile Phe Lys Ala Met Gly Gln Gly Leu Pro Asp Glu Glu Gln
 465                 470                 475                 480
 Glu Lys Leu Leu Arg Ile Cys Ser Ile Tyr Thr Gln Ser Gly Glu Asn
                 485                 490                 495    
 Ser Leu Val Gln Glu Gly Ser Glu Ala Ser Pro Ile Gly Lys Ser Pro
             500                 505                 510        
 Tyr Thr Leu Asp Ser Leu Tyr Trp Ser Val Lys Pro Ala Ser Ser Ser
         515                 520                 525            
 Phe Gly Ser Glu Ala Lys Ala Gln Gln Gln Glu Glu Gln Gly Ser Val
     530                 535                 540                
 Asn Asp Val Lys Glu Glu Glu Lys Glu Glu Lys Glu Val Leu Pro Asp
 545                 550                 555                 560
 Gln Glu Glu Glu Asp Glu Asp Asp Glu Asp Asp Glu Glu Glu Glu Glu
                 565                 570                 575    
 Asp Glu Asp Asp Glu Asp Asp Glu Glu Glu Asp Arg Met Glu Val Gly
             580                 585                 590        
 Pro Phe Ser Thr Gly Gln Glu Ser Pro Thr Ala Glu Asn Ala Arg Leu
         595                 600                 605            
 Leu Ala Gln Lys Arg Gly Ala Leu Gln Gly Ser Ala Trp Gln Val Ser
     610                 615                 620                
 Ser Glu Asp Val Arg Trp Asp Thr Phe Pro Leu Gly Arg Met Pro Gly
 625                 630                 635                 640
 Gln Thr Glu Asp Pro Ala Glu Leu Met Leu Glu Asn Tyr Asp Thr Met
                 645                 650                 655    
 Tyr Leu Leu Asp Gln Pro Val Leu Glu Gln Arg Leu Glu Pro Ser Thr
             660                 665                 670        
 Cys Lys Thr Asp Thr Leu Gly Leu Ser Cys Gly Val Gly Ser Gly Asn
         675                 680                 685            
 Cys Ser Asn Ser Ser Ser Ser Asn Phe Glu Gly Leu Leu Trp Ser Gln
     690                 695                 700                
 Gly Gln Leu His Gly Leu Lys Thr Gly Leu Gln Leu Phe
 705                 710                 715        



      <210> 1009
      <211> 940
      <212> PRT
      <213> Homo sapiens


      <400> 1009
 Met Ile Arg Thr Glu Ile Thr Gly Ala Glu Ile Ala Glu Glu Met Glu
   1               5                  10                  15    
 Lys Glu Arg Arg Leu Phe Gln Leu Gln Met Cys Glu Tyr Leu Ile Lys
              20                  25                  30        
 Val Asn Glu Ile Lys Thr Lys Lys Gly Val Asp Leu Leu Gln Asn Leu
          35                  40                  45            
 Ile Lys Tyr Tyr His Ala Gln Cys Asn Phe Phe Gln Asp Gly Leu Lys
      50                  55                  60                
 Thr Ala Asp Lys Leu Lys Gln Tyr Ile Glu Lys Leu Ala Ala Asp Leu
  65                  70                  75                  80
 Tyr Asn Ile Lys Gln Thr Gln Asp Glu Glu Lys Lys Gln Leu Thr Ala
                  85                  90                  95    
 Leu Arg Asp Leu Ile Lys Ser Ser Leu Gln Leu Asp Gln Lys Glu Ser
             100                 105                 110        
 Arg Arg Asp Ser Gln Ser Arg Gln Gly Gly Tyr Ser Met His Gln Leu
         115                 120                 125            
 Gln Gly Asn Lys Glu Tyr Gly Ser Glu Lys Lys Gly Tyr Leu Leu Lys
     130                 135                 140                
 Lys Ser Asp Gly Ile Arg Lys Val Trp Gln Arg Arg Lys Cys Ser Val
 145                 150                 155                 160
 Lys Asn Gly Ile Leu Thr Ile Ser His Ala Thr Ser Asn Arg Gln Pro
                 165                 170                 175    
 Ala Lys Leu Asn Leu Leu Thr Cys Gln Val Lys Pro Asn Ala Glu Asp
             180                 185                 190        
 Lys Lys Ser Phe Asp Leu Ile Ser His Asn Arg Thr Tyr His Phe Gln
         195                 200                 205            
 Ala Glu Asp Glu Gln Asp Tyr Val Ala Trp Ile Ser Val Leu Thr Asn
     210                 215                 220                
 Ser Lys Glu Glu Ala Leu Thr Met Ala Phe Arg Gly Glu Gln Ser Ala
 225                 230                 235                 240
 Gly Glu Asn Ser Leu Glu Asp Leu Thr Lys Ala Ile Ile Glu Asp Val
                 245                 250                 255    
 Gln Arg Leu Pro Gly Asn Asp Ile Cys Cys Asp Cys Gly Ser Ser Glu
             260                 265                 270        
 Pro Thr Trp Leu Ser Thr Asn Leu Gly Ile Leu Thr Cys Ile Glu Cys
         275                 280                 285            
 Ser Gly Ile His Arg Glu Met Gly Val His Ile Ser Arg Ile Gln Ser
     290                 295                 300                
 Leu Glu Leu Asp Lys Leu Gly Thr Ser Glu Leu Leu Leu Ala Lys Asn
 305                 310                 315                 320
 Val Gly Asn Asn Ser Phe Asn Asp Ile Met Glu Ala Asn Leu Pro Ser
                 325                 330                 335    
 Pro Ser Pro Lys Pro Thr Pro Ser Ser Asp Met Thr Val Arg Lys Glu
             340                 345                 350        
 Tyr Ile Thr Ala Lys Tyr Val Asp His Arg Phe Ser Arg Lys Thr Cys
         355                 360                 365            
 Ser Thr Ser Ser Ala Lys Leu Asn Glu Leu Leu Glu Ala Ile Lys Ser
     370                 375                 380                
 Arg Asp Leu Leu Ala Leu Ile Gln Val Tyr Ala Glu Gly Val Glu Leu
 385                 390                 395                 400
 Met Glu Pro Leu Leu Glu Pro Gly Gln Glu Leu Gly Glu Thr Ala Leu
                 405                 410                 415    
 His Leu Ala Val Arg Thr Ala Asp Gln Thr Ser Leu His Leu Val Asp
             420                 425                 430        
 Phe Leu Val Gln Asn Cys Gly Asn Leu Asp Lys Gln Thr Ala Leu Gly
         435                 440                 445            
 Asn Thr Val Leu His Tyr Cys Ser Met Tyr Ser Lys Pro Glu Cys Leu
     450                 455                 460                
 Lys Leu Leu Leu Arg Ser Lys Pro Thr Val Asp Ile Val Asn Gln Ala
 465                 470                 475                 480
 Gly Glu Thr Ala Leu Asp Ile Ala Lys Arg Leu Lys Ala Thr Gln Cys
                 485                 490                 495    
 Glu Asp Leu Leu Ser Gln Ala Lys Ser Gly Lys Phe Asn Pro His Val
             500                 505                 510        
 His Val Glu Tyr Glu Trp Asn Leu Arg Gln Glu Glu Ile Asp Glu Ser
         515                 520                 525            
 Asp Asp Asp Leu Asp Asp Lys Pro Ser Pro Ile Lys Lys Glu Arg Ser
     530                 535                 540                
 Pro Arg Pro Gln Ser Phe Cys His Ser Ser Ser Ile Ser Pro Gln Asp
 545                 550                 555                 560
 Lys Leu Ala Leu Pro Gly Phe Ser Thr Pro Arg Asp Lys Gln Arg Leu
                 565                 570                 575    
 Ser Tyr Gly Ala Phe Thr Asn Gln Ile Phe Val Ser Thr Ser Thr Asp
             580                 585                 590        
 Ser Pro Thr Ser Pro Thr Thr Glu Ala Pro Pro Leu Pro Pro Arg Asn
         595                 600                 605            
 Ala Gly Lys Gly Pro Thr Gly Pro Pro Ser Thr Leu Pro Leu Ser Thr
     610                 615                 620                
 Gln Thr Ser Ser Gly Ser Ser Thr Leu Ser Lys Lys Arg Pro Pro Pro
 625                 630                 635                 640
 Pro Pro Pro Gly His Lys Arg Thr Leu Ser Asp Pro Pro Ser Pro Leu
                 645                 650                 655    
 Pro His Gly Pro Pro Asn Lys Gly Ala Val Pro Trp Gly Asn Asp Gly
             660                 665                 670        
 Gly Pro Ser Ser Ser Ser Lys Thr Thr Asn Lys Phe Glu Gly Leu Ser
         675                 680                 685            
 Gln Gln Ser Ser Thr Ser Ser Ala Lys Thr Ala Leu Gly Pro Arg Val
     690                 695                 700                
 Leu Pro Lys Leu Pro Gln Lys Val Ala Leu Arg Lys Thr Asp His Leu
 705                 710                 715                 720
 Ser Leu Asp Lys Ala Thr Ile Pro Pro Glu Ile Phe Gln Lys Ser Ser
                 725                 730                 735    
 Gln Leu Ala Glu Leu Pro Gln Lys Pro Pro Pro Gly Asp Leu Pro Pro
             740                 745                 750        
 Lys Pro Thr Glu Leu Ala Pro Lys Pro Gln Ile Gly Asp Leu Pro Pro
         755                 760                 765            
 Lys Pro Gly Glu Leu Pro Pro Lys Pro Gln Leu Gly Asp Leu Pro Pro
     770                 775                 780                
 Lys Pro Gln Leu Ser Asp Leu Pro Pro Lys Pro Gln Met Lys Asp Leu
 785                 790                 795                 800
 Pro Pro Lys Pro Gln Leu Gly Asp Leu Leu Ala Lys Ser Gln Thr Gly
                 805                 810                 815    
 Asp Val Ser Pro Lys Ala Gln Gln Pro Ser Glu Val Thr Leu Lys Ser
             820                 825                 830        
 His Pro Leu Asp Leu Ser Pro Asn Val Gln Ser Arg Asp Ala Ile Gln
         835                 840                 845            
 Lys Gln Ala Ser Glu Asp Ser Asn Asp Leu Thr Pro Thr Leu Pro Glu
     850                 855                 860                
 Thr Pro Val Pro Leu Pro Arg Lys Ile Asn Thr Gly Lys Asn Lys Val
 865                 870                 875                 880
 Arg Arg Val Lys Thr Ile Tyr Asp Cys Gln Ala Asp Asn Asp Asp Glu
                 885                 890                 895    
 Leu Thr Phe Ile Glu Gly Glu Val Ile Ile Val Thr Gly Glu Glu Asp
             900                 905                 910        
 Gln Glu Trp Trp Ile Gly His Ile Glu Gly Gln Pro Glu Arg Lys Gly
         915                 920                 925            
 Val Phe Pro Val Ser Phe Val His Ile Leu Ser Asp
     930                 935                 940



      <210> 1010
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 1010
 Met Pro His Phe Leu Asp Trp Phe Val Pro Val Tyr Leu Val Ile Ser
   1               5                  10                  15    
 Val Leu Ile Leu Gly Gly Phe Gly Ala Cys Ile Tyr Tyr Phe Glu Pro
              20                  25                  30        
 Gly Leu Gln Glu Ala His Lys Trp Arg Met Gln Arg Pro Leu Val Asp
          35                  40                  45            
 Arg Asp Leu Arg Lys Thr Leu Met Val Arg Asp Asn Leu Ala Phe Gly
      50                  55                  60                
 Gly Pro Glu Val
  65            



      <210> 1011
      <211> 650
      <212> PRT
      <213> Homo sapiens


      <400> 1011
 Met Val Glu Ser Val Arg Leu Glu Asn Gln Pro Cys Asp Leu Arg Val
   1               5                  10                  15    
 Gly Ser Trp Ile His Val Tyr Pro Asn Gly Ser Leu Phe Ile Gly Ser
              20                  25                  30        
 Val Thr Glu Lys Asp Ser Gly Val Tyr Leu Cys Val Ala Arg Asn Lys
          35                  40                  45            
 Met Gly Asp Asp Leu Ile Leu Met His Val Ser Leu Arg Leu Lys Pro
      50                  55                  60                
 Ala Lys Ile Asp His Lys Gln Tyr Phe Arg Lys Gln Val Leu His Gly
  65                  70                  75                  80
 Lys Asp Phe Gln Val Asp Cys Lys Ala Ser Gly Ser Pro Val Pro Glu
                  85                  90                  95    
 Ile Ser Trp Ser Leu Leu Asp Gly Thr Met Ile Asn Asn Ala Met Gln
             100                 105                 110        
 Ala Asp Asp Ser Gly His Arg Thr Arg Arg Tyr Thr Leu Phe Asn Asn
         115                 120                 125            
 Gly Thr Leu Tyr Phe Asn Lys Val Gly Val Ala Glu Glu Gly Asp Tyr
     130                 135                 140                
 Thr Cys Tyr Ala Gln Asn Thr Leu Gly Lys Asp Glu Met Lys Val His
 145                 150                 155                 160
 Leu Thr Val Ile Thr Ala Ala Pro Arg Ile Arg Gln Ser Asn Lys Thr
                 165                 170                 175    
 Asn Lys Arg Ile Lys Ala Gly Asp Thr Ala Val Leu Asp Cys Glu Val
             180                 185                 190        
 Thr Gly Asp Pro Lys Pro Lys Ile Phe Trp Leu Leu Pro Ser Asn Asp
         195                 200                 205            
 Met Ile Ser Phe Ser Ile Asp Arg Tyr Thr Phe His Ala Asn Gly Ser
     210                 215                 220                
 Leu Thr Ile Asn Lys Val Lys Leu Leu Asp Ser Gly Glu Tyr Val Cys
 225                 230                 235                 240
 Val Ala Arg Asn Pro Ser Gly Asp Asp Thr Lys Met Tyr Lys Leu Asp
                 245                 250                 255    
 Val Val Ser Lys Pro Pro Leu Ile Asn Gly Leu Tyr Thr Asn Arg Thr
             260                 265                 270        
 Val Ile Lys Ala Thr Ala Val Arg His Ser Lys Lys His Phe Asp Cys
         275                 280                 285            
 Arg Ala Glu Gly Thr Pro Ser Pro Glu Val Met Trp Ile Met Pro Asp
     290                 295                 300                
 Asn Ile Phe Leu Thr Ala Pro Tyr Tyr Gly Ser Arg Ile Thr Val His
 305                 310                 315                 320
 Lys Asn Gly Thr Leu Glu Ile Arg Asn Val Arg Leu Ser Asp Ser Ala
                 325                 330                 335    
 Asp Phe Ile Cys Val Ala Arg Asn Glu Gly Gly Glu Ser Val Leu Val
             340                 345                 350        
 Val Gln Leu Glu Val Leu Glu Met Leu Arg Arg Pro Thr Phe Arg Asn
         355                 360                 365            
 Pro Phe Asn Glu Lys Ile Val Ala Gln Leu Gly Lys Ser Thr Ala Leu
     370                 375                 380                
 Asn Cys Ser Val Asp Gly Asn Pro Pro Pro Glu Ile Ile Trp Ile Leu
 385                 390                 395                 400
 Pro Asn Gly Thr Arg Phe Ser Asn Gly Pro Gln Ser Tyr Gln Tyr Leu
                 405                 410                 415    
 Ile Ala Ser Asn Gly Ser Phe Ile Ile Ser Lys Thr Thr Arg Glu Asp
             420                 425                 430        
 Ala Gly Lys Tyr Arg Cys Ala Ala Arg Asn Lys Val Gly Tyr Ile Glu
         435                 440                 445            
 Lys Leu Val Ile Leu Glu Ile Gly Gln Lys Pro Val Ile Leu Thr Tyr
     450                 455                 460                
 Ala Pro Gly Thr Val Lys Gly Ile Ser Gly Glu Ser Leu Ser Leu His
 465                 470                 475                 480
 Cys Val Ser Asp Gly Ile Pro Lys Pro Asn Ile Lys Trp Thr Met Pro
                 485                 490                 495    
 Ser Gly Tyr Val Val Asp Arg Pro Gln Ile Asn Gly Lys Tyr Ile Leu
             500                 505                 510        
 His Asp Asn Gly Thr Leu Val Ile Lys Glu Ala Thr Ala Tyr Asp Arg
         515                 520                 525            
 Gly Asn Tyr Ile Cys Lys Ala Gln Asn Ser Val Gly His Thr Leu Ile
     530                 535                 540                
 Thr Val Pro Val Met Ile Val Ala Tyr Pro Pro Arg Ile Thr Asn Arg
 545                 550                 555                 560
 Pro Pro Arg Ser Ile Val Thr Arg Thr Gly Ala Ala Phe Gln Leu His
                 565                 570                 575    
 Cys Val Ala Leu Gly Val Pro Lys Pro Glu Ile Thr Trp Glu Met Pro
             580                 585                 590        
 Asp His Ser Leu Leu Ser Thr Ala Ser Lys Glu Arg Thr His Gly Ser
         595                 600                 605            
 Glu Gln Leu His Leu Gln Gly Thr Leu Val Ile Gln Asn Pro Gln Thr
     610                 615                 620                
 Ser Asp Ser Gly Ile Tyr Lys Cys Thr Ala Lys Asn Pro Leu Gly Ser
 625                 630                 635                 640
 Asp Tyr Ala Ala Thr Tyr Ile Gln Val Ile
                 645                 650



      <210> 1012
      <211> 315
      <212> PRT
      <213> Homo sapiens


      <400> 1012
 Met Gln Leu Phe Glu Gln Pro Cys Pro Gly Glu Asp Pro Arg Pro Gly
   1               5                  10                  15    
 Gly Gln Ile Gly Glu Val Glu Leu Ser Ser Tyr Thr Pro Pro Ala Gly
              20                  25                  30        
 Val Pro Gly Lys Pro Ala Ala Pro His Phe Leu Pro Val Leu Cys Ser
          35                  40                  45            
 Val Ser Pro Ser Gly Ser Arg Val Pro His Asp Leu Leu Gly Gly Ser
      50                  55                  60                
 Gly Gly Phe Thr Leu Glu Asp Ala Leu Phe Gly Leu Leu Phe Gly Ala
  65                  70                  75                  80
 Asp Ala Thr Leu Leu Gln Ser Pro Val Val Leu Cys Gly Leu Pro Asp
                  85                  90                  95    
 Gly Gln Leu Cys Cys Val Ile Leu Lys Ala Leu Val Thr Ser Arg Ser
             100                 105                 110        
 Ala Pro Gly Asp Pro Asn Ala Leu Val Lys Ile Leu His His Leu Glu
         115                 120                 125            
 Glu Pro Val Ile Phe Ile Gly Ala Leu Lys Thr Glu Pro Gln Ala Ala
     130                 135                 140                
 Glu Ala Ala Glu Asn Phe Leu Pro Asp Glu Asp Val His Cys Asp Cys
 145                 150                 155                 160
 Leu Val Ala Phe Gly His His Gly Arg Met Leu Ala Ile Lys Ala Ser
                 165                 170                 175    
 Trp Asp Glu Ser Gly Lys Leu Val Pro Glu Leu Arg Glu Tyr Cys Leu
             180                 185                 190        
 Pro Gly Pro Val Leu Cys Ala Ala Cys Gly Gly Gly Gly Arg Val Tyr
         195                 200                 205            
 His Ser Thr Pro Ser Asp Leu Cys Val Val Asp Leu Ser Arg Gly Ser
     210                 215                 220                
 Thr Pro Leu Gly Pro Glu Gln Pro Glu Glu Gly Pro Gly Gly Leu Pro
 225                 230                 235                 240
 Pro Met Leu Cys Pro Ala Ser Leu Asn Ile Cys Ser Val Val Ser Leu
                 245                 250                 255    
 Ser Ala Ser Pro Arg Thr His Glu Gly Gly Thr Lys Leu Leu Ala Leu
             260                 265                 270        
 Ser Ala Lys Gly Arg Leu Met Thr Cys Ser Leu Asp Leu Asp Ser Glu
         275                 280                 285            
 Met Pro Gly Pro Ala Arg Met Thr Thr Glu Gln Cys Arg Ser Glu Asn
     290                 295                 300                
 Lys Gly Ala Ala Val Trp Asn Trp Gln His Leu
 305                 310                 315



      <210> 1013
      <211> 283
      <212> PRT
      <213> Homo sapiens


      <400> 1013
 Met Ala Gly Ala Val Ser Leu Leu Gly Val Val Gly Leu Leu Leu Val
   1               5                  10                  15    
 Ser Ala Leu Ser Gly Val Leu Gly Asp Arg Ala Asn Pro Asp Leu Arg
              20                  25                  30        
 Ala His Pro Gly Asn Ala Ala His Pro Gly Ser Gly Ala Thr Glu Pro
          35                  40                  45            
 Arg Arg Arg Pro Pro Leu Lys Asp Gln Arg Glu Arg Thr Arg Ala Gly
      50                  55                  60                
 Ser Leu Pro Leu Gly Ala Leu Tyr Thr Ala Ala Val Ala Ala Phe Val
  65                  70                  75                  80
 Leu Tyr Lys Cys Leu Gln Gly Lys Asp Glu Thr Ala Val Leu His Glu
                  85                  90                  95    
 Glu Ala Ser Lys Gln Gln Pro Leu Gln Ser Glu Gln Gln Leu Ala Gln
             100                 105                 110        
 Leu Thr Gln Gln Leu Ala Gln Thr Glu Gln His Leu Asn Asn Leu Met
         115                 120                 125            
 Ala Gln Leu Asp Pro Leu Phe Glu Arg Val Thr Thr Leu Ala Gly Ala
     130                 135                 140                
 Gln Gln Glu Leu Leu Asn Met Lys Leu Trp Thr Ile His Glu Leu Leu
 145                 150                 155                 160
 Gln Asp Ser Lys Pro Asp Lys Asp Met Glu Ala Ser Glu Pro Gly Glu
                 165                 170                 175    
 Gly Ser Gly Gly Glu Ser Ala Gly Gly Gly Asp Lys Val Ser Glu Thr
             180                 185                 190        
 Gly Thr Phe Leu Ile Ser Pro His Thr Glu Ala Ser Arg Pro Leu Pro
         195                 200                 205            
 Glu Asp Phe Cys Leu Lys Glu Asp Glu Glu Glu Ile Gly Asp Ser Gln
     210                 215                 220                
 Ala Trp Glu Glu Pro Thr Asn Trp Ser Thr Glu Thr Trp Asn Leu Ala
 225                 230                 235                 240
 Thr Ser Trp Glu Val Gly Arg Gly Leu Arg Arg Arg Cys Ser Gln Ala
                 245                 250                 255    
 Val Ala Lys Gly Pro Ser His Ser Leu Gly Trp Glu Gly Gly Thr Thr
             260                 265                 270        
 Ala Glu Gly Arg Leu Lys Gln Ser Leu Phe Ser
         275                 280            



      <210> 1014
      <211> 256
      <212> PRT
      <213> Homo sapiens


      <400> 1014
 Met Ala Gly Ala Val Ser Leu Leu Gly Val Val Gly Leu Leu Leu Val
   1               5                  10                  15    
 Ser Ala Leu Ser Gly Val Leu Gly Asp Arg Ala Asn Pro Asp Leu Arg
              20                  25                  30        
 Ala His Pro Gly Asn Ala Ala His Pro Gly Ser Gly Ala Thr Glu Pro
          35                  40                  45            
 Arg Arg Arg Pro Pro Leu Lys Asp Gln Arg Glu Arg Thr Arg Ala Gly
      50                  55                  60                
 Ser Leu Pro Leu Gly Ala Leu Tyr Thr Ala Ala Val Ala Ala Phe Val
  65                  70                  75                  80
 Leu Tyr Lys Cys Leu Gln Gly Lys Asp Glu Thr Ala Val Leu His Glu
                  85                  90                  95    
 Glu Ala Ser Lys Gln Gln Pro Leu Gln Ser Glu Gln Gln Leu Ala Gln
             100                 105                 110        
 Leu Thr Gln Gln Leu Ala Gln Thr Glu Gln His Leu Asn Asn Leu Met
         115                 120                 125            
 Ala Gln Leu Asp Pro Leu Phe Glu Arg Val Thr Thr Leu Ala Gly Ala
     130                 135                 140                
 Gln Gln Glu Leu Leu Asn Met Lys Leu Trp Thr Ile His Glu Leu Leu
 145                 150                 155                 160
 Gln Asp Ser Lys Pro Asp Lys Asp Met Glu Ala Ser Glu Pro Glu Ala
                 165                 170                 175    
 Ser Arg Pro Leu Pro Glu Asp Phe Cys Leu Lys Glu Asp Glu Glu Glu
             180                 185                 190        
 Ile Gly Asp Ser Gln Ala Trp Glu Glu Pro Thr Asn Trp Ser Thr Glu
         195                 200                 205            
 Thr Trp Asn Leu Ala Thr Ser Trp Glu Val Gly Arg Gly Leu Arg Arg
     210                 215                 220                
 Arg Cys Ser Gln Ala Val Ala Lys Gly Pro Ser His Ser Leu Gly Trp
 225                 230                 235                 240
 Glu Gly Gly Thr Thr Ala Glu Gly Arg Leu Lys Gln Ser Leu Phe Ser
                 245                 250                 255    





      <210> 1015
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 1015
 Met Ser Leu Ala Leu Arg Ser Glu Leu Leu Val Asp Lys Thr Lys Arg
   1               5                  10                  15    
 Lys Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile Lys Asp
              20                  25                  30        
 Ala Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp Tyr His
          35                  40                  45            
 Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys Lys Ala
      50                  55                  60                
 Asp Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr Gly Lys
  65                  70                  75                  80
 Ile Thr Phe Glu Asp Phe Asn Glu Val Val Thr Asp Trp Ile Leu Glu
                  85                  90                  95    
 Arg Asp Pro His Glu Glu Ile Leu Lys Ala Phe Lys Leu Phe Asp Asp
             100                 105                 110        
 Asp Asp Ser Gly Lys Ile Ser Leu Arg Asn Leu Arg Arg Val Ala Arg
         115                 120                 125            
 Glu Leu Gly Glu Asn Met Ser Asp Glu Glu Leu Arg Ala Met Ile Glu
     130                 135                 140                
 Glu Phe Asp Lys Asp Gly Asp Gly Glu Ile Asn Gln Glu Glu Phe Ile
 145                 150                 155                 160
 Ala Ile Met Thr Gly Asp Ile
                 165        



      <210> 1016
      <211> 483
      <212> PRT
      <213> Homo sapiens


      <400> 1016
 Met Arg Gln Ala Asp Gly Arg Lys Val Leu Arg Ser Ser Ile Arg Glu
   1               5                  10                  15    
 Phe Leu Cys Ser Glu Ala Met Phe His Leu Gly Val Pro Thr Thr Arg
              20                  25                  30        
 Ala Gly Ala Cys Val Thr Ser Glu Ser Thr Val Val Arg Asp Val Phe
          35                  40                  45            
 Tyr Asp Gly Asn Pro Lys Tyr Glu Gln Cys Thr Val Val Leu Arg Val
      50                  55                  60                
 Ala Ser Thr Phe Ile Arg Phe Gly Ser Phe Glu Ile Phe Lys Ser Ala
  65                  70                  75                  80
 Asp Glu His Thr Gly Arg Ala Gly Pro Ser Val Gly Arg Asn Asp Ile
                  85                  90                  95    
 Arg Val Gln Leu Leu Asp Tyr Val Ile Ser Ser Phe Tyr Pro Glu Ile
             100                 105                 110        
 Gln Ala Ala His Ala Ser Asp Ser Val Gln Arg Asn Ala Ala Phe Phe
         115                 120                 125            
 Arg Glu Val Thr Arg Arg Thr Ala Arg Met Val Ala Glu Trp Gln Cys
     130                 135                 140                
 Val Gly Phe Cys His Gly Val Leu Asn Thr Asp Asn Met Ser Ile Leu
 145                 150                 155                 160
 Gly Leu Thr Ile Asp Tyr Gly Pro Phe Gly Phe Leu Asp Arg Tyr Asp
                 165                 170                 175    
 Pro Asp His Val Cys Asn Ala Ser Asp Asn Thr Gly Arg Tyr Ala Tyr
             180                 185                 190        
 Ser Lys Gln Pro Glu Val Cys Arg Trp Asn Leu Arg Lys Leu Ala Glu
         195                 200                 205            
 Ala Leu Gln Pro Glu Leu Pro Leu Glu Leu Gly Glu Ala Ile Leu Ala
     210                 215                 220                
 Glu Glu Phe Asp Ala Glu Phe Gln Arg His Tyr Leu Gln Lys Met Arg
 225                 230                 235                 240
 Arg Lys Leu Gly Leu Val Gln Val Glu Leu Glu Glu Asp Gly Ala Leu
                 245                 250                 255    
 Val Ser Lys Leu Leu Glu Thr Met His Leu Thr Gly Ala Asp Phe Thr
             260                 265                 270        
 Asn Thr Phe Tyr Leu Leu Ser Ser Phe Pro Val Glu Leu Glu Ser Pro
         275                 280                 285            
 Gly Leu Ala Glu Phe Leu Ala Arg Leu Met Glu Gln Cys Ala Ser Leu
     290                 295                 300                
 Glu Glu Leu Arg Leu Ala Phe Arg Pro Gln Met Asp Pro Arg Gln Leu
 305                 310                 315                 320
 Ser Met Met Leu Met Leu Ala Gln Ser Asn Pro Gln Leu Phe Ala Leu
                 325                 330                 335    
 Met Gly Thr Arg Ala Gly Ile Ala Arg Glu Leu Glu Arg Val Glu Gln
             340                 345                 350        
 Gln Ser Arg Leu Glu Gln Leu Ser Ala Ala Glu Leu Gln Ser Arg Asn
         355                 360                 365            
 Gln Gly His Trp Ala Asp Trp Leu Gln Ala Tyr Arg Ala Arg Leu Asp
     370                 375                 380                
 Lys Asp Leu Glu Gly Ala Gly Asp Ala Ala Ala Trp Gln Ala Glu His
 385                 390                 395                 400
 Val Arg Val Met His Ala Asn Asn Pro Lys Tyr Val Leu Arg Asn Tyr
                 405                 410                 415    
 Ile Ala Gln Asn Ala Ile Glu Ala Ala Glu Arg Gly Asp Phe Ser Glu
             420                 425                 430        
 Val Arg Arg Val Leu Lys Leu Leu Glu Thr Pro Tyr His Cys Glu Ala
         435                 440                 445            
 Gly Ala Ala Thr Asp Ala Glu Ala Thr Glu Ala Asp Gly Ala Asp Gly
     450                 455                 460                
 Arg Gln Arg Ser Tyr Ser Ser Lys Pro Pro Leu Trp Ala Ala Glu Leu
 465                 470                 475                 480
 Cys Val Thr
            



      <210> 1017
      <211> 815
      <212> PRT
      <213> Homo sapiens


      <400> 1017
 Met Ala Val Tyr Arg Ala Ala Leu Gly Ala Ser Leu Ala Ala Ala Arg
   1               5                  10                  15    
 Leu Leu Pro Leu Gly Arg Cys Ser Pro Ser Pro Ala Pro Arg Ser Thr
              20                  25                  30        
 Leu Ser Gly Ala Ala Met Glu Pro Ala Pro Arg Trp Leu Ala Gly Leu
          35                  40                  45            
 Arg Phe Asp Asn Arg Ala Leu Arg Ala Leu Pro Val Glu Ala Pro Pro
      50                  55                  60                
 Pro Gly Pro Glu Gly Ala Pro Ser Ala Pro Arg Pro Val Pro Gly Ala
  65                  70                  75                  80
 Cys Phe Thr Arg Val Gln Pro Thr Pro Leu Arg Gln Pro Arg Leu Val
                  85                  90                  95    
 Ala Leu Ser Glu Pro Ala Leu Ala Leu Leu Gly Leu Gly Ala Pro Pro
             100                 105                 110        
 Ala Arg Glu Ala Glu Ala Glu Ala Ala Leu Phe Phe Ser Gly Asn Ala
         115                 120                 125            
 Leu Leu Pro Gly Ala Glu Pro Ala Ala His Cys Tyr Cys Gly His Gln
     130                 135                 140                
 Phe Gly Gln Phe Ala Gly Gln Leu Gly Asp Gly Ala Ala Met Tyr Leu
 145                 150                 155                 160
 Gly Glu Val Cys Thr Ala Thr Gly Glu Arg Trp Glu Leu Gln Leu Lys
                 165                 170                 175    
 Gly Ala Gly Pro Thr Pro Phe Ser Arg Gln Ala Asp Gly Arg Lys Val
             180                 185                 190        
 Leu Arg Ser Ser Ile Arg Glu Phe Leu Cys Ser Glu Ala Met Phe His
         195                 200                 205            
 Leu Gly Val Pro Thr Thr Arg Ala Gly Ala Cys Val Thr Ser Glu Ser
     210                 215                 220                
 Thr Val Val Arg Asp Val Phe Tyr Asp Gly Asn Pro Lys Tyr Glu Gln
 225                 230                 235                 240
 Cys Thr Val Val Leu Arg Val Ala Ser Thr Phe Ile Arg Pro Ser Leu
                 245                 250                 255    
 Gln Pro Glu Met Ala Leu Arg Glu Leu Val Cys Leu Lys Ala Pro Ala
             260                 265                 270        
 Gly Gly Ser Arg Ala Thr Gly Thr Arg Glu Gly Ser Leu Pro Gly Ala
         275                 280                 285            
 Ser Gly Gly Glu Gly Val Pro Glu Pro Glu Ala Gly Asp Ser Val Gln
     290                 295                 300                
 Ser Cys Leu Leu Glu Phe Met Thr Arg Asn Tyr Leu Asp Leu Thr Glu
 305                 310                 315                 320
 Glu Met Ala Thr Glu Glu Ala Gly Ala Ala Ser Trp Gly Trp Glu Arg
                 325                 330                 335    
 Ser Gly Ala Thr Thr Ser Ser Glu Ala Pro Pro Ser Gly Asn Ala Gly
             340                 345                 350        
 Ile Val Val Lys Ser Thr Leu Cys Ala His Ser Ile Pro Ala Leu Gly
         355                 360                 365            
 Pro Leu Val Ala Ser Ser Asn Pro Ser Cys Asp Asn Glu Lys Cys Val
     370                 375                 380                
 Gln Thr Leu Pro Asp Val Pro Trp Gly Ala Val Thr Leu Gly Asp Gly
 385                 390                 395                 400
 Cys Trp Phe Gly Ser Phe Glu Ile Phe Lys Ser Ala Asp Glu His Thr
                 405                 410                 415    
 Gly Arg Ala Gly Pro Ser Val Gly Arg Asn Asp Ile Arg Val Gln Leu
             420                 425                 430        
 Leu Asp Tyr Val Ile Ser Ser Phe Tyr Pro Glu Ile Gln Ala Ala His
         435                 440                 445            
 Ala Ser Asp Ser Val Gln Arg Asn Ala Ala Phe Phe Arg Glu Val Thr
     450                 455                 460                
 Arg Arg Thr Ala Arg Met Val Ala Glu Trp Gln Cys Val Gly Phe Cys
 465                 470                 475                 480
 His Gly Val Leu Asn Thr Asp Asn Met Ser Ile Leu Gly Leu Thr Ile
                 485                 490                 495    
 Asp Tyr Gly Pro Phe Gly Phe Leu Asp Arg Tyr Asp Pro Asp His Val
             500                 505                 510        
 Cys Asn Ala Ser Asp Asn Thr Gly Arg Tyr Ala Tyr Ser Lys Gln Pro
         515                 520                 525            
 Glu Val Cys Arg Trp Asn Leu Arg Lys Leu Ala Glu Ala Leu Gln Pro
     530                 535                 540                
 Glu Leu Pro Leu Glu Leu Gly Glu Ala Ile Leu Ala Glu Glu Phe Asp
 545                 550                 555                 560
 Ala Glu Phe Gln Arg His Tyr Leu Gln Lys Met Arg Arg Lys Leu Gly
                 565                 570                 575    
 Leu Val Gln Val Glu Leu Glu Glu Asp Gly Ala Leu Val Ser Lys Leu
             580                 585                 590        
 Leu Glu Thr Met His Leu Thr Gly Ala Asp Phe Thr Asn Thr Phe Tyr
         595                 600                 605            
 Leu Leu Ser Ser Phe Pro Val Glu Leu Glu Ser Pro Gly Leu Ala Glu
     610                 615                 620                
 Phe Leu Ala Arg Leu Met Glu Gln Cys Ala Ser Leu Glu Glu Leu Arg
 625                 630                 635                 640
 Leu Ala Phe Arg Pro Gln Met Asp Pro Arg Gln Leu Ser Met Met Leu
                 645                 650                 655    
 Met Leu Ala Gln Ser Asn Pro Gln Leu Phe Ala Leu Met Gly Thr Arg
             660                 665                 670        
 Ala Gly Ile Ala Arg Glu Leu Glu Arg Val Glu Gln Gln Ser Arg Leu
         675                 680                 685            
 Glu Gln Leu Ser Ala Ala Glu Leu Gln Ser Arg Asn Gln Gly His Trp
     690                 695                 700                
 Ala Asp Trp Leu Gln Ala Tyr Arg Ala Arg Leu Asp Lys Asp Leu Glu
 705                 710                 715                 720
 Gly Ala Gly Asp Ala Ala Ala Trp Gln Ala Glu His Val Arg Val Met
                 725                 730                 735    
 His Ala Asn Asn Pro Lys Tyr Val Leu Arg Asn Tyr Ile Ala Gln Asn
             740                 745                 750        
 Ala Ile Glu Ala Ala Glu Arg Gly Asp Phe Ser Glu Val Arg Arg Val
         755                 760                 765            
 Leu Lys Leu Leu Glu Thr Pro Tyr His Cys Glu Ala Gly Ala Ala Thr
     770                 775                 780                
 Asp Ala Glu Ala Thr Glu Ala Asp Gly Ala Asp Gly Arg Gln Arg Ser
 785                 790                 795                 800
 Tyr Ser Ser Lys Pro Pro Leu Trp Ala Ala Glu Leu Cys Val Thr
                 805                 810                 815



      <210> 1018
      <211> 471
      <212> PRT
      <213> Homo sapiens


      <400> 1018
 Met Asn Pro Pro Ser Gly Pro Arg Val Pro Pro Ser Pro Thr Gln Glu
   1               5                  10                  15    
 Pro Ser Cys Met Ala Thr Pro Ala Pro Pro Ser Trp Trp Asp Ser Ser
              20                  25                  30        
 Gln Ser Ser Ile Ser Ser Leu Gly Arg Leu Pro Ser Ile Ser Pro Thr
          35                  40                  45            
 Ala Pro Gly Thr Trp Ala Ala Ala Trp Val Pro Leu Pro Thr Val Asp
      50                  55                  60                
 Val Pro Asp His Ala His Tyr Thr Leu Gly Thr Val Ile Leu Leu Val
  65                  70                  75                  80
 Gly Leu Thr Gly Met Leu Gly Asn Leu Thr Val Ile Tyr Thr Phe Cys
                  85                  90                  95    
 Arg Ser Arg Ser Leu Arg Thr Pro Ala Asn Met Phe Ile Ile Asn Leu
             100                 105                 110        
 Ala Val Ser Asp Phe Leu Met Ser Phe Thr Gln Ala Pro Val Phe Phe
         115                 120                 125            
 Thr Ser Ser Leu Tyr Lys Gln Trp Leu Phe Gly Glu Thr Gly Cys Glu
     130                 135                 140                
 Phe Tyr Ala Phe Cys Gly Ala Leu Phe Gly Ile Ser Ser Met Ile Thr
 145                 150                 155                 160
 Leu Thr Ala Ile Ala Leu Asp Arg Tyr Leu Val Ile Thr Arg Pro Leu
                 165                 170                 175    
 Ala Thr Phe Gly Val Ala Ser Lys Arg Arg Ala Ala Phe Val Leu Leu
             180                 185                 190        
 Gly Val Trp Leu Tyr Ala Leu Ala Trp Ser Leu Pro Pro Phe Phe Gly
         195                 200                 205            
 Trp Ser Ala Tyr Val Pro Glu Gly Leu Leu Thr Ser Cys Ser Trp Asp
     210                 215                 220                
 Tyr Met Ser Phe Thr Pro Ala Val Arg Ala Tyr Thr Met Leu Leu Cys
 225                 230                 235                 240
 Cys Phe Val Phe Phe Leu Pro Leu Leu Ile Ile Ile Tyr Cys Tyr Ile
                 245                 250                 255    
 Phe Ile Phe Arg Ala Ile Arg Glu Thr Gly Arg Ala Leu Gln Thr Phe
             260                 265                 270        
 Gly Ala Cys Lys Gly Asn Gly Glu Ser Leu Trp Gln Arg Gln Arg Leu
         275                 280                 285            
 Gln Ser Glu Cys Lys Met Ala Lys Ile Met Leu Leu Val Ile Leu Leu
     290                 295                 300                
 Phe Val Leu Ser Trp Ala Pro Tyr Ser Ala Val Ala Leu Val Ala Phe
 305                 310                 315                 320
 Ala Gly Tyr Ala His Val Leu Thr Pro Tyr Met Ser Ser Val Pro Ala
                 325                 330                 335    
 Val Ile Ala Lys Ala Ser Ala Ile His Asn Pro Ile Ile Tyr Ala Ile
             340                 345                 350        
 Thr His Pro Lys Tyr Arg Val Ala Ile Ala Gln His Leu Pro Cys Leu
         355                 360                 365            
 Gly Val Leu Leu Gly Val Ser Arg Arg His Ser Arg Pro Tyr Pro Ser
     370                 375                 380                
 Tyr Arg Ser Thr His Arg Ser Thr Leu Thr Ser His Thr Ser Asn Leu
 385                 390                 395                 400
 Ser Trp Ile Ser Ile Arg Arg Arg Gln Glu Ser Leu Gly Ser Glu Ser
                 405                 410                 415    
 Glu Val Gly Trp Ala Gly His Thr Trp Arg Gln Gln Leu Cys Gly Glu
             420                 425                 430        
 Leu Pro Ser Lys Gln Met Gly Gly Pro Ser Thr Val Arg Val Trp Arg
         435                 440                 445            
 Thr Trp Lys Pro Arg His Pro Pro Asp Pro Arg Asp Thr Lys Gln Arg
     450                 455                 460                
 Leu Gln Gly Arg Pro Arg Gly
 465                 470    



      <210> 1019
      <211> 692
      <212> PRT
      <213> Homo sapiens


      <400> 1019
 Met Glu Leu Leu Pro Leu Trp Leu Cys Leu Gly Phe His Phe Leu Thr
   1               5                  10                  15    
 Val Gly Trp Arg Asn Arg Ser Gly Thr Ala Thr Ala Ala Ser Gln Gly
              20                  25                  30        
 Val Cys Lys Leu Val Gly Gly Ala Ala Asp Cys Arg Gly Gln Ser Leu
          35                  40                  45            
 Ala Ser Val Pro Ser Ser Leu Pro Pro His Ala Arg Met Leu Thr Leu
      50                  55                  60                
 Asp Ala Asn Pro Leu Lys Thr Leu Trp Asn His Ser Leu Gln Pro Tyr
  65                  70                  75                  80
 Pro Leu Leu Glu Ser Leu Ser Leu His Ser Cys His Leu Glu Arg Ile
                  85                  90                  95    
 Ser Arg Gly Ala Phe Gln Glu Gln Gly His Leu Arg Ser Leu Val Leu
             100                 105                 110        
 Gly Asp Asn Cys Leu Ser Glu Asn Tyr Glu Glu Thr Ala Ala Ala Leu
         115                 120                 125            
 His Ala Leu Pro Gly Leu Arg Arg Leu Asp Leu Ser Gly Asn Ala Leu
     130                 135                 140                
 Thr Glu Asp Met Ala Ala Leu Met Leu Gln Asn Leu Ser Ser Leu Arg
 145                 150                 155                 160
 Ser Val Ser Leu Ala Gly Asn Thr Ile Met Arg Leu Asp Asp Ser Val
                 165                 170                 175    
 Phe Glu Gly Leu Glu Arg Leu Arg Glu Leu Asp Leu Gln Arg Asn Tyr
             180                 185                 190        
 Ile Phe Glu Ile Glu Gly Gly Ala Phe Asp Gly Leu Ala Glu Leu Arg
         195                 200                 205            
 His Leu Asn Leu Ala Phe Asn Asn Leu Pro Cys Ile Val Asp Phe Gly
     210                 215                 220                
 Leu Thr Arg Leu Arg Val Leu Asn Val Ser Tyr Asn Val Leu Glu Trp
 225                 230                 235                 240
 Phe Leu Ala Thr Gly Gly Glu Ala Ala Phe Glu Leu Glu Thr Leu Asp
                 245                 250                 255    
 Leu Ser His Asn Gln Leu Leu Phe Phe Pro Leu Leu Pro Gln Tyr Ser
             260                 265                 270        
 Lys Leu Arg Thr Leu Leu Leu Arg Asp Asn Asn Met Gly Phe Tyr Arg
         275                 280                 285            
 Asp Leu Tyr Asn Thr Ser Ser Pro Arg Glu Met Val Ala Gln Phe Leu
     290                 295                 300                
 Leu Val Asp Gly Asn Val Thr Asn Ile Thr Thr Val Ser Leu Trp Glu
 305                 310                 315                 320
 Glu Phe Ser Ser Ser Asp Leu Ala Asp Leu Arg Phe Leu Asp Met Ser
                 325                 330                 335    
 Gln Asn Gln Phe Gln Tyr Leu Pro Asp Gly Phe Leu Arg Lys Met Pro
             340                 345                 350        
 Ser Leu Ser His Leu Asn Leu His Gln Asn Cys Leu Met Thr Leu His
         355                 360                 365            
 Ile Arg Glu His Glu Pro Pro Gly Ala Leu Thr Glu Leu Asp Leu Ser
     370                 375                 380                
 His Asn Gln Leu Ser Glu Leu His Leu Ala Pro Gly Leu Ala Ser Cys
 385                 390                 395                 400
 Leu Gly Ser Leu Arg Leu Phe Asn Leu Ser Ser Asn Gln Leu Leu Gly
                 405                 410                 415    
 Val Pro Pro Gly Leu Phe Ala Asn Ala Arg Asn Ile Thr Thr Leu Asp
             420                 425                 430        
 Met Ser His Asn Gln Ile Ser Leu Cys Pro Leu Pro Ala Ala Ser Asp
         435                 440                 445            
 Arg Val Gly Pro Pro Ser Cys Val Asp Phe Arg Asn Met Ala Ser Leu
     450                 455                 460                
 Arg Ser Leu Ser Leu Glu Gly Cys Gly Leu Gly Ala Leu Pro Asp Cys
 465                 470                 475                 480
 Pro Phe Gln Gly Thr Ser Leu Thr Tyr Leu Asp Leu Ser Ser Asn Trp
                 485                 490                 495    
 Gly Val Leu Asn Gly Ser Leu Ala Pro Leu Gln Asp Val Ala Pro Met
             500                 505                 510        
 Leu Gln Val Leu Ser Leu Arg Asn Met Gly Leu His Ser Ser Phe Met
         515                 520                 525            
 Ala Leu Asp Phe Ser Gly Phe Gly Asn Leu Arg Asp Leu Asp Leu Ser
     530                 535                 540                
 Gly Asn Cys Leu Pro Ile Phe Pro Arg Phe Gly Gly Ser Leu Ala Leu
 545                 550                 555                 560
 Glu Thr Leu Asp Leu Arg Arg Asn Ser Leu Thr Ala Leu Pro Gln Lys
                 565                 570                 575    
 Ala Val Ser Glu Gln Leu Ser Arg Gly Leu Arg Thr Ile Tyr Leu Ser
             580                 585                 590        
 Gln Asn Pro Tyr Asp Cys Cys Gly Val Asp Gly Trp Gly Ala Leu Gln
         595                 600                 605            
 His Gly Gln Thr Val Ala Asp Trp Ala Met Val Thr Cys Asn Leu Ser
     610                 615                 620                
 Ser Lys Ile Ile Arg Val Thr Glu Leu Pro Gly Gly Val Pro Arg Asp
 625                 630                 635                 640
 Cys Lys Trp Glu Arg Leu Asp Leu Gly Leu Leu Tyr Leu Val Leu Ile
                 645                 650                 655    
 Leu Pro Ser Cys Leu Thr Leu Leu Val Ala Cys Thr Val Ile Val Leu
             660                 665                 670        
 Thr Phe Lys Lys Pro Leu Leu Gln Val Ile Lys Ser Arg Cys His Trp
         675                 680                 685            
 Ser Ser Val Tyr
     690        



      <210> 1020
      <211> 255
      <212> PRT
      <213> Homo sapiens


      <400> 1020
 Met Ile Leu Gln Gln Asp Phe Thr Ser Ile Arg Phe Pro Ala Leu Glu
   1               5                  10                  15    
 His Cys Tyr Thr Gly Gly Glu Val Val Leu Pro Lys Asp Gln Glu Glu
              20                  25                  30        
 Trp Lys Arg Arg Thr Gly Leu Leu Leu Tyr Glu Asn Tyr Gly Gln Ser
          35                  40                  45            
 Glu Thr Gly Leu Ile Cys Ala Thr Tyr Trp Gly Met Lys Ile Lys Pro
      50                  55                  60                
 Gly Phe Met Gly Lys Ala Thr Pro Pro Tyr Asp Val Gln Val Ile Asp
  65                  70                  75                  80
 Asp Lys Gly Ser Ile Leu Pro Pro Asn Thr Glu Gly Asn Ile Gly Ile
                  85                  90                  95    
 Arg Ile Lys Pro Val Arg Pro Val Ser Leu Phe Met Cys Tyr Glu Gly
             100                 105                 110        
 Asp Pro Glu Lys Thr Ala Lys Val Glu Cys Gly Asp Phe Tyr Asn Thr
         115                 120                 125            
 Gly Asp Arg Gly Lys Met Asp Glu Glu Gly Tyr Ile Cys Phe Leu Gly
     130                 135                 140                
 Arg Ser Asp Asp Ile Ile Asn Ala Ser Gly Tyr Arg Ile Gly Pro Ala
 145                 150                 155                 160
 Glu Val Glu Ser Ala Leu Val Glu His Pro Ala Val Ala Glu Ser Ala
                 165                 170                 175    
 Val Val Gly Ser Pro Asp Pro Ile Arg Gly Glu Val Val Lys Ala Phe
             180                 185                 190        
 Ile Val Leu Thr Pro Gln Phe Leu Ser His Asp Lys Asp Gln Leu Thr
         195                 200                 205            
 Lys Glu Leu Gln Gln His Val Lys Ser Val Thr Ala Pro Tyr Lys Tyr
     210                 215                 220                
 Pro Arg Lys Val Glu Phe Val Ser Glu Leu Pro Lys Thr Ile Thr Gly
 225                 230                 235                 240
 Lys Ile Glu Arg Lys Glu Leu Arg Lys Lys Glu Thr Gly Gln Met
                 245                 250                 255



      <210> 1021
      <211> 1204
      <212> PRT
      <213> Homo sapiens


      <400> 1021
 Met Ala Pro Thr Leu Phe Gln Lys Leu Phe Ser Lys Arg Thr Gly Leu
   1               5                  10                  15    
 Gly Ala Pro Gly Arg Asp Ala Arg Asp Pro Asp Cys Gly Phe Ser Trp
              20                  25                  30        
 Pro Leu Pro Glu Phe Asp Pro Ser Gln Ile Arg Leu Ile Val Tyr Gln
          35                  40                  45            
 Asp Cys Glu Arg Arg Gly Arg Asn Val Leu Phe Asp Ser Ser Val Lys
      50                  55                  60                
 Arg Arg Asn Glu Asp Ile Ser Val Ser Asp Leu Asn Thr Ile Tyr Ser
  65                  70                  75                  80
 Tyr Leu His Gly Met Glu Ile Leu Ser Asn Leu Arg Glu His Gln Leu
                  85                  90                  95    
 Arg Leu Met Ser Ala Arg Ala Arg Tyr Glu Arg Tyr Ser Gly Asn Gln
             100                 105                 110        
 Val Leu Phe Cys Ser Glu Thr Ile Ala Arg Cys Trp Tyr Ile Leu Leu
         115                 120                 125            
 Ser Gly Ser Val Leu Val Lys Gly Ser Met Val Leu Pro Pro Cys Ser
     130                 135                 140                
 Phe Gly Lys Gln Phe Gly Gly Lys Arg Gly Cys Asp Cys Leu Val Leu
 145                 150                 155                 160
 Glu Pro Ser Glu Met Ile Val Val Glu Asn Ala Lys Asp Asn Glu Asp
                 165                 170                 175    
 Ser Ile Leu Gln Arg Glu Ile Pro Ala Arg Gln Ser Arg Arg Arg Phe
             180                 185                 190        
 Arg Lys Ile Asn Tyr Lys Gly Glu Arg Gln Thr Ile Thr Asp Asp Val
         195                 200                 205            
 Glu Val Asn Ser Tyr Leu Ser Leu Pro Ala Asp Leu Thr Lys Met His
     210                 215                 220                
 Leu Thr Glu Asn Pro His Pro Gln Val Thr His Val Ser Ser Ser Gln
 225                 230                 235                 240
 Ser Gly Cys Ser Ile Ala Ser Asp Ser Gly Ser Ser Ser Leu Ser Asp
                 245                 250                 255    
 Ile Tyr Gln Ala Thr Glu Ser Glu Val Gly Asp Val Asp Leu Thr Arg
             260                 265                 270        
 Leu Pro Glu Gly Pro Val Asp Ser Glu Asp Asp Glu Glu Glu Asp Glu
         275                 280                 285            
 Glu Ile Asp Arg Thr Asp Pro Leu Gln Gly Arg Asp Leu Val Arg Glu
     290                 295                 300                
 Cys Leu Glu Lys Glu Pro Ala Asp Lys Thr Asp Asp Asp Ile Glu Gln
 305                 310                 315                 320
 Leu Leu Glu Phe Met His Gln Leu Pro Ala Phe Ala Asn Met Thr Met
                 325                 330                 335    
 Ser Val Arg Arg Glu Leu Cys Ser Val Met Ile Phe Glu Val Val Glu
             340                 345                 350        
 Gln Ala Gly Ala Ile Ile Leu Glu Asp Gly Gln Glu Leu Asp Ser Trp
         355                 360                 365            
 Tyr Val Ile Leu Asn Gly Thr Val Glu Ile Ser His Pro Asp Gly Lys
     370                 375                 380                
 Val Glu Asn Leu Phe Met Gly Asn Ser Phe Gly Ile Thr Pro Thr Leu
 385                 390                 395                 400
 Asp Lys Gln Tyr Met His Gly Ile Val Arg Thr Lys Val Asp Asp Cys
                 405                 410                 415    
 Gln Phe Val Cys Ile Ala Gln Gln Asp Tyr Trp Arg Ile Leu Asn His
             420                 425                 430        
 Val Glu Lys Asn Thr His Lys Val Glu Glu Glu Gly Glu Ile Val Met
         435                 440                 445            
 Val His Glu His Arg Glu Leu Asp Arg Ser Gly Thr Arg Lys Gly His
     450                 455                 460                
 Ile Val Ile Lys Ala Thr Pro Glu Arg Leu Ile Met His Leu Ile Glu
 465                 470                 475                 480
 Glu His Ser Ile Val Asp Pro Thr Tyr Ile Glu Asp Phe Leu Leu Thr
                 485                 490                 495    
 Tyr Arg Thr Phe Leu Glu Ser Pro Leu Asp Val Gly Ile Lys Leu Leu
             500                 505                 510        
 Glu Trp Phe Lys Ile Asp Ser Leu Arg Asp Lys Val Thr Arg Ile Val
         515                 520                 525            
 Leu Leu Trp Val Asn Asn His Phe Asn Asp Phe Glu Gly Asp Pro Ala
     530                 535                 540                
 Met Thr Arg Phe Leu Glu Glu Phe Glu Lys Asn Leu Glu Asp Thr Lys
 545                 550                 555                 560
 Met Asn Gly His Leu Arg Leu Leu Asn Ile Ala Cys Ala Ala Lys Ala
                 565                 570                 575    
 Lys Trp Arg Gln Val Val Leu Gln Lys Ala Ser Arg Glu Ser Pro Leu
             580                 585                 590        
 Gln Phe Ser Leu Asn Gly Gly Ser Glu Lys Gly Phe Gly Ile Phe Val
         595                 600                 605            
 Glu Gly Val Glu Pro Gly Ser Lys Ala Ala Asp Ser Gly Leu Lys Arg
     610                 615                 620                
 Gly Asp Gln Ile Met Glu Val Asn Gly Gln Asn Phe Glu Asn Ile Thr
 625                 630                 635                 640
 Phe Met Lys Ala Val Glu Ile Leu Arg Asn Asn Thr His Leu Ala Leu
                 645                 650                 655    
 Thr Val Lys Thr Asn Ile Phe Val Phe Lys Glu Leu Leu Phe Arg Thr
             660                 665                 670        
 Glu Gln Glu Lys Ser Gly Val Pro His Ile Pro Lys Ile Ala Glu Lys
         675                 680                 685            
 Lys Ser Asn Arg His Ser Ile Gln His Val Pro Gly Asp Ile Glu Gln
     690                 695                 700                
 Thr Ser Gln Glu Lys Gly Ser Lys Lys Val Lys Ala Asn Thr Val Ser
 705                 710                 715                 720
 Gly Gly Arg Asn Lys Ile Arg Lys Ile Leu Asp Lys Thr Arg Phe Ser
                 725                 730                 735    
 Ile Leu Pro Pro Lys Leu Phe Ser Asp Gly Gly Leu Ser Gln Ser Gln
             740                 745                 750        
 Asp Asp Ser Ile Val Gly Thr Arg His Cys Arg His Ser Leu Ala Ile
         755                 760                 765            
 Met Pro Ile Pro Gly Thr Leu Ser Ser Ser Ser Pro Asp Leu Leu Gln
     770                 775                 780                
 Pro Thr Thr Ser Met Leu Asp Phe Ser Asn Pro Ser Asp Ile Pro Asp
 785                 790                 795                 800
 Gln Val Ile Arg Val Phe Lys Val Asp Gln Gln Ser Cys Tyr Ile Ile
                 805                 810                 815    
 Ile Ser Lys Asp Thr Thr Ala Lys Glu Val Val Phe His Ala Val His
             820                 825                 830        
 Glu Phe Gly Leu Thr Gly Ala Ser Asp Thr Tyr Ser Leu Cys Glu Val
         835                 840                 845            
 Ser Val Thr Pro Glu Gly Val Ile Lys Gln Arg Arg Leu Pro Asp Gln
     850                 855                 860                
 Phe Ser Lys Leu Ala Asp Arg Ile Gln Leu Asn Gly Arg Tyr Tyr Leu
 865                 870                 875                 880
 Lys Asn Asn Met Glu Thr Glu Thr Leu Cys Ser Asp Glu Asp Ala Gln
                 885                 890                 895    
 Glu Leu Val Lys Glu Ser Gln Leu Ser Met Leu Gln Leu Ser Thr Ile
             900                 905                 910        
 Glu Val Ala Thr Gln Leu Ser Met Arg Asp Phe Asp Leu Phe Arg Asn
         915                 920                 925            
 Ile Glu Pro Thr Glu Tyr Ile Asp Asp Leu Phe Lys Leu Asn Ser Lys
     930                 935                 940                
 Thr Gly Asn Thr His Leu Lys Arg Phe Glu Asp Ile Val Asn Gln Glu
 945                 950                 955                 960
 Thr Phe Trp Val Ala Ser Glu Ile Leu Thr Glu Ala Asn Gln Leu Lys
                 965                 970                 975    
 Arg Met Lys Ile Ile Lys His Phe Ile Lys Ile Ala Leu His Cys Arg
             980                 985                 990        
 Glu Cys Lys Asn Phe Asn Ser Met Phe Ala Ile Ile Ser Gly Leu Asn
         995                1000                1005            
 Leu Ala Ser Val Ala Arg Leu Arg Gly Thr Trp Glu Lys Leu Pro Ser
    1010                1015                1020                
 Lys Tyr Glu Lys His Leu Gln Asp Leu Gln Asp Ile Phe Asp Pro Ser
1025                1030                1035                1040
 Arg Asn Met Ala Lys Tyr Arg Asn Ile Leu Ser Ser Gln Ser Met Gln
                1045                1050                1055    
 Pro Pro Ile Ile Pro Leu Phe Pro Val Val Lys Lys Asp Met Thr Phe
            1060                1065                1070        
 Leu His Glu Gly Asn Asp Ser Lys Val Asp Gly Leu Val Asn Phe Glu
        1075                1080                1085            
 Lys Leu Arg Met Ile Ser Lys Glu Ile Arg Gln Val Val Arg Met Thr
    1090                1095                1100                
 Ser Ala Asn Met Asp Pro Ala Met Met Phe Arg Gln Arg Ser Leu Ser
1105                1110                1115                1120
 Gln Gly Ser Thr Asn Ser Asn Met Leu Asp Val Gln Gly Gly Ala His
                1125                1130                1135    
 Lys Lys Arg Ala Arg Arg Ser Ser Leu Leu Asn Ala Lys Lys Leu Tyr
            1140                1145                1150        
 Glu Asp Ala Gln Met Ala Arg Lys Val Lys Gln Tyr Leu Ser Ser Leu
        1155                1160                1165            
 Asp Val Glu Thr Asp Glu Glu Lys Phe Gln Met Met Ser Leu Gln Trp
    1170                1175                1180                
 Glu Pro Ala Tyr Gly Thr Leu Thr Lys Asn Leu Ser Glu Lys Arg Ser
1185                1190                1195                1200
 Ala Lys Ile Ile
                



      <210> 1022
      <211> 1154
      <212> PRT
      <213> Homo sapiens


      <400> 1022
 Met Asn Ser Pro Val Asp Pro Gly Ala Arg Gln Ala Leu Arg Lys Lys
   1               5                  10                  15    
 Pro Pro Glu Arg Thr Pro Glu Asp Leu Asn Thr Ile Tyr Ser Tyr Leu
              20                  25                  30        
 His Gly Met Glu Ile Leu Ser Asn Leu Arg Glu His Gln Leu Arg Leu
          35                  40                  45            
 Met Ser Ala Arg Ala Arg Tyr Glu Arg Tyr Ser Gly Asn Gln Val Leu
      50                  55                  60                
 Phe Cys Ser Glu Thr Ile Ala Arg Cys Trp Tyr Ile Leu Leu Ser Gly
  65                  70                  75                  80
 Ser Val Leu Val Lys Gly Ser Met Val Leu Pro Pro Cys Ser Phe Gly
                  85                  90                  95    
 Lys Gln Phe Gly Gly Lys Arg Gly Cys Asp Cys Leu Val Leu Glu Pro
             100                 105                 110        
 Ser Glu Met Ile Val Val Glu Asn Ala Lys Asp Asn Glu Asp Ser Ile
         115                 120                 125            
 Leu Gln Arg Glu Ile Pro Ala Arg Gln Ser Arg Arg Arg Phe Arg Lys
     130                 135                 140                
 Ile Asn Tyr Lys Gly Glu Arg Gln Thr Ile Thr Asp Asp Val Glu Val
 145                 150                 155                 160
 Asn Ser Tyr Leu Ser Leu Pro Ala Asp Leu Thr Lys Met His Leu Thr
                 165                 170                 175    
 Glu Asn Pro His Pro Gln Val Thr His Val Ser Ser Ser Gln Ser Gly
             180                 185                 190        
 Cys Ser Ile Ala Ser Asp Ser Gly Ser Ser Ser Leu Ser Asp Ile Tyr
         195                 200                 205            
 Gln Ala Thr Glu Ser Glu Val Gly Asp Val Asp Leu Thr Arg Leu Pro
     210                 215                 220                
 Glu Gly Pro Val Asp Ser Glu Asp Asp Glu Glu Glu Asp Glu Glu Ile
 225                 230                 235                 240
 Asp Arg Thr Asp Pro Leu Gln Gly Arg Asp Leu Val Arg Glu Cys Leu
                 245                 250                 255    
 Glu Lys Glu Pro Ala Asp Lys Thr Asp Asp Asp Ile Glu Gln Leu Leu
             260                 265                 270        
 Glu Phe Met His Gln Leu Pro Ala Phe Ala Asn Met Thr Met Ser Val
         275                 280                 285            
 Arg Arg Glu Leu Cys Ser Val Met Ile Phe Glu Val Val Glu Gln Ala
     290                 295                 300                
 Gly Ala Ile Ile Leu Glu Asp Gly Gln Glu Leu Asp Ser Trp Tyr Val
 305                 310                 315                 320
 Ile Leu Asn Gly Thr Val Glu Ile Ser His Pro Asp Gly Lys Val Glu
                 325                 330                 335    
 Asn Leu Phe Met Gly Asn Ser Phe Gly Ile Thr Pro Thr Leu Asp Lys
             340                 345                 350        
 Gln Tyr Met His Gly Ile Val Arg Thr Lys Val Asp Asp Cys Gln Phe
         355                 360                 365            
 Val Cys Ile Ala Gln Gln Asp Tyr Trp Arg Ile Leu Asn His Val Glu
     370                 375                 380                
 Lys Asn Thr His Lys Val Glu Glu Glu Gly Glu Ile Val Met Val His
 385                 390                 395                 400
 Glu His Arg Glu Leu Asp Arg Ser Gly Thr Arg Lys Gly His Ile Val
                 405                 410                 415    
 Ile Lys Ala Thr Pro Glu Arg Leu Ile Met His Leu Ile Glu Glu His
             420                 425                 430        
 Ser Ile Val Asp Pro Thr Tyr Ile Glu Asp Phe Leu Leu Thr Tyr Arg
         435                 440                 445            
 Thr Phe Leu Glu Ser Pro Leu Asp Val Gly Ile Lys Leu Leu Glu Trp
     450                 455                 460                
 Phe Lys Ile Asp Ser Leu Arg Asp Lys Val Thr Arg Ile Val Leu Leu
 465                 470                 475                 480
 Trp Val Asn Asn His Phe Asn Asp Phe Glu Gly Asp Pro Ala Met Thr
                 485                 490                 495    
 Arg Phe Leu Glu Glu Phe Glu Lys Asn Leu Glu Asp Thr Lys Met Asn
             500                 505                 510        
 Gly His Leu Arg Leu Leu Asn Ile Ala Cys Ala Ala Lys Ala Lys Trp
         515                 520                 525            
 Arg Gln Val Val Leu Gln Lys Ala Ser Arg Glu Ser Pro Leu Gln Phe
     530                 535                 540                
 Ser Leu Asn Gly Gly Ser Glu Lys Gly Phe Gly Ile Phe Val Glu Gly
 545                 550                 555                 560
 Val Glu Pro Gly Ser Lys Ala Ala Asp Ser Gly Leu Lys Arg Gly Asp
                 565                 570                 575    
 Gln Ile Met Glu Val Asn Gly Gln Asn Phe Glu Asn Ile Thr Phe Met
             580                 585                 590        
 Lys Ala Val Glu Ile Leu Arg Asn Asn Thr His Leu Ala Leu Thr Val
         595                 600                 605            
 Lys Thr Asn Ile Phe Val Phe Lys Glu Leu Leu Phe Arg Thr Glu Gln
     610                 615                 620                
 Glu Lys Ser Gly Val Pro His Ile Pro Lys Ile Ala Glu Lys Lys Ser
 625                 630                 635                 640
 Asn Arg His Ser Ile Gln His Val Pro Gly Asp Ile Glu Gln Thr Ser
                 645                 650                 655    
 Gln Glu Lys Gly Ser Lys Lys Val Lys Ala Asn Thr Val Ser Gly Gly
             660                 665                 670        
 Arg Asn Lys Ile Arg Lys Ile Leu Asp Lys Thr Arg Phe Ser Ile Leu
         675                 680                 685            
 Pro Pro Lys Leu Phe Ser Asp Gly Gly Leu Ser Gln Ser Gln Asp Asp
     690                 695                 700                
 Ser Ile Val Gly Thr Arg His Cys Arg His Ser Leu Ala Ile Met Pro
 705                 710                 715                 720
 Ile Pro Gly Thr Leu Ser Ser Ser Ser Pro Asp Leu Leu Gln Pro Thr
                 725                 730                 735    
 Thr Ser Met Leu Asp Phe Ser Asn Pro Ser Asp Ile Pro Asp Gln Val
             740                 745                 750        
 Ile Arg Val Phe Lys Val Asp Gln Gln Ser Cys Tyr Ile Ile Ile Ser
         755                 760                 765            
 Lys Asp Thr Thr Ala Lys Glu Val Val Phe His Ala Val His Glu Phe
     770                 775                 780                
 Gly Leu Thr Gly Ala Ser Asp Thr Tyr Ser Leu Cys Glu Val Ser Val
 785                 790                 795                 800
 Thr Pro Glu Gly Val Ile Lys Gln Arg Arg Leu Pro Asp Gln Phe Ser
                 805                 810                 815    
 Lys Leu Ala Asp Arg Ile Gln Leu Asn Gly Arg Tyr Tyr Leu Lys Asn
             820                 825                 830        
 Asn Met Glu Thr Glu Thr Leu Cys Ser Asp Glu Asp Ala Gln Glu Leu
         835                 840                 845            
 Val Lys Glu Ser Gln Leu Ser Met Leu Gln Leu Ser Thr Ile Glu Val
     850                 855                 860                
 Ala Thr Gln Leu Ser Met Arg Asp Phe Asp Leu Phe Arg Asn Ile Glu
 865                 870                 875                 880
 Pro Thr Glu Tyr Ile Asp Asp Leu Phe Lys Leu Asn Ser Lys Thr Gly
                 885                 890                 895    
 Asn Thr His Leu Lys Arg Phe Glu Asp Ile Val Asn Gln Glu Thr Phe
             900                 905                 910        
 Trp Val Ala Ser Glu Ile Leu Thr Glu Ala Asn Gln Leu Lys Arg Met
         915                 920                 925            
 Lys Ile Ile Lys His Phe Ile Lys Ile Ala Leu His Cys Arg Glu Cys
     930                 935                 940                
 Lys Asn Phe Asn Ser Met Phe Ala Ile Ile Ser Gly Leu Asn Leu Ala
 945                 950                 955                 960
 Ser Val Ala Arg Leu Arg Gly Thr Trp Glu Lys Leu Pro Ser Lys Tyr
                 965                 970                 975    
 Glu Lys His Leu Gln Asp Leu Gln Asp Ile Phe Asp Pro Ser Arg Asn
             980                 985                 990        
 Met Ala Lys Tyr Arg Asn Ile Leu Ser Ser Gln Ser Met Gln Pro Pro
         995                1000                1005            
 Ile Ile Pro Leu Phe Pro Val Val Lys Lys Asp Met Thr Phe Leu His
    1010                1015                1020                
 Glu Gly Asn Asp Ser Lys Val Asp Gly Leu Val Asn Phe Glu Lys Leu
1025                1030                1035                1040
 Arg Met Ile Ser Lys Glu Ile Arg Gln Val Val Arg Met Thr Ser Ala
                1045                1050                1055    
 Asn Met Asp Pro Ala Met Met Phe Arg Gln Arg Ser Leu Ser Gln Gly
            1060                1065                1070        
 Ser Thr Asn Ser Asn Met Leu Asp Val Gln Gly Gly Ala His Lys Lys
        1075                1080                1085            
 Arg Ala Arg Arg Ser Ser Leu Leu Asn Ala Lys Lys Leu Tyr Glu Asp
    1090                1095                1100                
 Ala Gln Met Ala Arg Lys Val Lys Gln Tyr Leu Ser Ser Leu Asp Val
1105                1110                1115                1120
 Glu Thr Asp Glu Glu Lys Phe Gln Met Met Ser Leu Gln Trp Glu Pro
                1125                1130                1135    
 Ala Tyr Gly Thr Leu Thr Lys Asn Leu Ser Glu Lys Arg Ser Ala Lys
            1140                1145                1150        
 Ile Ile
        



      <210> 1023
      <211> 263
      <212> PRT
      <213> Homo sapiens


      <400> 1023
 Met Arg Ile Phe Arg Pro Trp Arg Leu Arg Cys Pro Ala Leu His Leu
   1               5                  10                  15    
 Pro Ser Leu Ser Val Phe Ser Leu Arg Trp Lys Leu Pro Ser Leu Thr
              20                  25                  30        
 Thr Asp Glu Thr Met Cys Lys Ser Val Thr Thr Asp Glu Trp Lys Lys
          35                  40                  45            
 Val Phe Tyr Glu Lys Met Glu Glu Ala Lys Pro Ala Asp Ser Trp Asp
      50                  55                  60                
 Leu Ile Ile Asp Pro Asn Leu Lys His Asn Val Leu Ser Pro Gly Trp
  65                  70                  75                  80
 Lys Gln Tyr Leu Glu Leu His Ala Ser Gly Arg Phe His Cys Ser Trp
                  85                  90                  95    
 Cys Trp His Thr Trp Gln Ser Pro Tyr Val Val Ile Leu Phe His Met
             100                 105                 110        
 Phe Leu Asp Arg Ala Gln Arg Ala Gly Ser Val Arg Met Arg Val Phe
         115                 120                 125            
 Lys Gln Leu Cys Tyr Glu Cys Gly Thr Ala Arg Leu Asp Glu Ser Ser
     130                 135                 140                
 Met Leu Glu Glu Asn Ile Glu Gly Leu Val Asp Asn Leu Ile Thr Ser
 145                 150                 155                 160
 Leu Arg Glu Gln Cys Tyr Gly Glu Arg Gly Gly Gln Tyr Arg Ile His
                 165                 170                 175    
 Val Ala Ser Arg Gln Asp Asn Arg Arg His Arg Gly Glu Phe Cys Glu
             180                 185                 190        
 Ala Cys Gln Glu Gly Ile Val His Trp Lys Pro Ser Glu Lys Leu Leu
         195                 200                 205            
 Glu Glu Glu Ala Thr Thr Tyr Thr Phe Ser Arg Ala Pro Ser Pro Thr
     210                 215                 220                
 Lys Ser Gln Asp Gln Thr Gly Ser Gly Trp Asn Phe Cys Ser Ile Pro
 225                 230                 235                 240
 Trp Cys Leu Phe Trp Ala Thr Val Leu Leu Leu Ile Ile Tyr Leu Gln
                 245                 250                 255    
 Phe Ser Phe Arg Ser Ser Val
             260            



      <210> 1024
      <211> 589
      <212> PRT
      <213> Homo sapiens


      <400> 1024
 Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile
   1               5                  10                  15    
 Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro
              20                  25                  30        
 His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Arg Lys Leu Leu
          35                  40                  45            
 Pro Arg Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser
      50                  55                  60                
 Pro Asp Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser
  65                  70                  75                  80
 Asp Pro Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His
                  85                  90                  95    
 Gly Gly Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile
             100                 105                 110        
 Arg Val Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His
         115                 120                 125            
 Gln Trp Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln
     130                 135                 140                
 Lys Ile Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu
 145                 150                 155                 160
 Leu Pro Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val
                 165                 170                 175    
 Arg Arg Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser
             180                 185                 190        
 Asp Phe Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln
         195                 200                 205            
 Met Val Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala
     210                 215                 220                
 Leu Cys Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn
 225                 230                 235                 240
 Ala Thr Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp
                 245                 250                 255    
 Leu His Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His
             260                 265                 270        
 Val Glu Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser
         275                 280                 285            
 Met Asp Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met
     290                 295                 300                
 His Ala Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp
 305                 310                 315                 320
 Thr Leu Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser
                 325                 330                 335    
 Pro Val Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys
             340                 345                 350        
 Val Leu Val Trp Arg Ser Asp Val Gln Phe Ala Trp Lys His Leu Leu
         355                 360                 365            
 Cys Pro Asp Val Ser Tyr Arg His Leu Gly Leu Leu Ile Leu Ala Leu
     370                 375                 380                
 Leu Ala Leu Leu Thr Leu Leu Gly Val Val Leu Ala Leu Thr Cys Arg
 385                 390                 395                 400
 Arg Pro Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu Leu Leu His
                 405                 410                 415    
 Ala Ala Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala Leu Ala Glu
             420                 425                 430        
 Leu Leu Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile Val Asp Leu
         435                 440                 445            
 Trp Glu Gly Arg His Val Ala Arg Val Gly Pro Leu Pro Trp Leu Trp
     450                 455                 460                
 Ala Ala Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val Leu Leu Leu
 465                 470                 475                 480
 Trp Ser Gly Ala Asp Leu Arg Pro Val Ser Gly Pro Asp Pro Arg Ala
                 485                 490                 495    
 Ala Pro Leu Leu Ala Leu Leu His Ala Ala Pro Arg Pro Leu Leu Leu
             500                 505                 510        
 Leu Ala Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro
         515                 520                 525            
 Leu Arg Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu
     530                 535                 540                
 Leu Arg Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly
 545                 550                 555                 560
 Arg Leu Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser
                 565                 570                 575    
 Arg Leu Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly
             580                 585                



      <210> 1025
      <211> 551
      <212> PRT
      <213> Homo sapiens


      <400> 1025
 Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg Arg His Leu Ser
   1               5                  10                  15    
 Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp Ile Ser His Lys
              20                  25                  30        
 Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro Glu Thr Trp Glu
          35                  40                  45            
 Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly Pro Glu Phe Ser
      50                  55                  60                
 Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val Thr Ile Ser Ser
  65                  70                  75                  80
 Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp Ala Leu Glu Cys
                  85                  90                  95    
 Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile Val Ser Gly Gly
             100                 105                 110        
 His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro Cys Leu Cys Ile
         115                 120                 125            
 Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg Lys Lys Cys Pro
     130                 135                 140                
 Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe Trp Lys Ser Val
 145                 150                 155                 160
 His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val Met Ala Leu Thr
                 165                 170                 175    
 Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys Gln Arg His Asp
             180                 185                 190        
 Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr Ala Arg Glu Ser
         195                 200                 205            
 Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His Pro Gln Leu Cys
     210                 215                 220                
 Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu Cys Pro His Gln
 225                 230                 235                 240
 Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp Thr Gln Ala Gln
                 245                 250                 255    
 Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala Thr Phe Ser Ala
             260                 265                 270        
 Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu Val Pro Pro Val
         275                 280                 285            
 Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val Ser Leu Asp Leu
     290                 295                 300                
 Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu Val Trp Arg Ser
 305                 310                 315                 320
 Asp Val Gln Phe Ala Trp Lys His Leu Leu Cys Pro Asp Val Ser Tyr
                 325                 330                 335    
 Arg His Leu Gly Leu Leu Ile Leu Ala Leu Leu Ala Leu Leu Thr Leu
             340                 345                 350        
 Leu Gly Val Val Leu Ala Leu Thr Cys Arg Arg Pro Gln Ser Gly Pro
         355                 360                 365            
 Gly Pro Ala Arg Pro Val Leu Leu Leu His Ala Ala Asp Ser Glu Ala
     370                 375                 380                
 Gln Arg Arg Leu Val Gly Ala Leu Ala Glu Leu Leu Arg Ala Ala Leu
 385                 390                 395                 400
 Gly Gly Gly Arg Asp Val Ile Val Asp Leu Trp Glu Gly Arg His Val
                 405                 410                 415    
 Ala Arg Val Gly Pro Leu Pro Trp Leu Trp Ala Ala Arg Thr Arg Val
             420                 425                 430        
 Ala Arg Glu Gln Gly Thr Val Leu Leu Leu Trp Ser Gly Ala Asp Leu
         435                 440                 445            
 Arg Pro Val Ser Gly Pro Asp Pro Arg Ala Ala Pro Leu Leu Ala Leu
     450                 455                 460                
 Leu His Ala Ala Pro Arg Pro Leu Leu Leu Leu Ala Tyr Phe Ser Arg
 465                 470                 475                 480
 Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro Leu Arg Ala Leu Pro Arg
                 485                 490                 495    
 Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu Leu Arg Ala Leu Asp Ala
             500                 505                 510        
 Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly Arg Leu Gly Ala Arg Gln
         515                 520                 525            
 Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser Arg Leu Glu Arg Glu Ala
     530                 535                 540                
 Ala Arg Leu Ala Asp Leu Gly
 545                 550    



      <210> 1026
      <211> 276
      <212> PRT
      <213> Homo sapiens


      <400> 1026
 Met Leu Ala Trp Arg Asp Gly Glu Leu Glu Ala Glu Thr Ser Ser Ser
   1               5                  10                  15    
 Leu Phe Leu Leu Ala Met Gln Val Trp Met Cys Gly Gly Arg Met Glu
              20                  25                  30        
 Asp Ile Pro Cys Ser Arg Val Gly His Ile Tyr Arg Lys Tyr Val Pro
          35                  40                  45            
 Tyr Lys Val Pro Ala Gly Val Ser Leu Ala Arg Val Arg Thr Leu Lys
      50                  55                  60                
 Arg Val Ala Glu Val Trp Met Asp Glu Tyr Ala Glu Tyr Ile Tyr Gln
  65                  70                  75                  80
 Arg Arg Pro Glu Tyr Arg His Leu Ser Ala Gly Asp Val Ala Val Gln
                  85                  90                  95    
 Lys Lys Leu Arg Ser Ser Leu Asn Cys Lys Ser Phe Lys Trp Phe Met
             100                 105                 110        
 Thr Lys Ile Ala Trp Asp Leu Pro Lys Phe Tyr Pro Pro Val Glu Pro
         115                 120                 125            
 Pro Ala Ala Ala Trp Gly Glu Ile Arg Asn Val Gly Thr Gly Leu Cys
     130                 135                 140                
 Ala Asp Thr Lys His Gly Ala Leu Gly Ser Pro Leu Arg Leu Glu Gly
 145                 150                 155                 160
 Cys Val Arg Gly Arg Gly Glu Ala Ala Trp Asn Asn Met Gln Val Phe
                 165                 170                 175    
 Thr Phe Thr Trp Arg Glu Asp Ile Arg Pro Gly Asp Pro Gln His Thr
             180                 185                 190        
 Lys Lys Phe Cys Phe Asp Ala Ile Ser His Thr Ser Pro Val Thr Leu
         195                 200                 205            
 Tyr Asp Cys His Ser Met Lys Gly Asn Gln Leu Trp Lys Tyr Arg Lys
     210                 215                 220                
 Asp Lys Thr Leu Tyr His Pro Val Ser Gly Ser Cys Met Asp Cys Ser
 225                 230                 235                 240
 Glu Ser Asp His Arg Ile Phe Met Asn Thr Cys Asn Pro Ser Ser Leu
                 245                 250                 255    
 Thr Gln Gln Trp Leu Phe Glu His Thr Asn Ser Thr Val Leu Glu Lys
             260                 265                 270        
 Phe Asn Arg Asn
         275    



      <210> 1027
      <211> 216
      <212> PRT
      <213> Homo sapiens


      <400> 1027
 Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu
   1               5                  10                  15    
 Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg
              20                  25                  30        
 Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro
          35                  40                  45            
 Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu
      50                  55                  60                
 Leu Phe Cys Leu Phe Phe His Ile Leu Gln Pro Ser His Cys Trp Ile
  65                  70                  75                  80
 Ser Glu Met Val Val Gln Leu Ser Asp Ser Leu Thr Asp Leu Leu Asp
                  85                  90                  95    
 Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser Asn Tyr Ser Ile Ile Asp
             100                 105                 110        
 Lys Leu Val Asn Ile Val Asp Asp Leu Val Glu Cys Val Lys Glu Asn
         115                 120                 125            
 Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys Ser Pro Glu Pro Arg Leu
     130                 135                 140                
 Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe Asn Arg Ser Ile Asp Ala
 145                 150                 155                 160
 Phe Lys Asp Phe Val Val Ala Ser Glu Thr Ser Asp Cys Val Val Ser
                 165                 170                 175    
 Ser Thr Leu Ser Pro Glu Lys Asp Ser Arg Val Ser Val Thr Lys Pro
             180                 185                 190        
 Phe Met Leu Pro Pro Val Ala Ala Ser Ser Leu Arg Asn Asp Ser Ser
         195                 200                 205            
 Ser Ser Asn Arg Lys Ala Trp Ile
     210                 215    



      <210> 1028
      <211> 636
      <212> PRT
      <213> Homo sapiens


      <400> 1028
 Met Trp Gly Leu Val Arg Leu Leu Leu Ala Trp Leu Gly Gly Trp Gly
   1               5                  10                  15    
 Cys Met Gly Arg Leu Ala Ala Pro Ala Arg Ala Trp Ala Gly Ser Arg
              20                  25                  30        
 Glu His Pro Gly Pro Ala Leu Leu Arg Thr Arg Arg Ser Trp Val Trp
          35                  40                  45            
 Asn Gln Phe Phe Val Ile Glu Glu Tyr Ala Gly Pro Glu Pro Val Leu
      50                  55                  60                
 Ile Gly Lys Leu His Ser Asp Val Asp Arg Gly Glu Gly Arg Thr Lys
  65                  70                  75                  80
 Tyr Leu Leu Thr Gly Glu Gly Ala Gly Thr Val Phe Val Ile Asp Glu
                  85                  90                  95    
 Ala Thr Gly Asn Ile His Val Thr Lys Ser Leu Asp Arg Glu Glu Lys
             100                 105                 110        
 Ala Gln Tyr Val Leu Leu Ala Gln Ala Val Asp Arg Ala Ser Asn Arg
         115                 120                 125            
 Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Gly Gln Asp Ile Asn
     130                 135                 140                
 Asp Asn Pro Pro Ile Phe Pro Leu Gly Pro Tyr His Ala Thr Val Pro
 145                 150                 155                 160
 Glu Met Ser Asn Val Gly Thr Ser Val Ile Gln Val Thr Ala His Asp
                 165                 170                 175    
 Ala Asp Asp Pro Ser Tyr Gly Asn Ser Ala Lys Leu Val Tyr Thr Val
             180                 185                 190        
 Leu Asp Gly Leu Pro Phe Phe Ser Val Asp Pro Gln Thr Gly Val Val
         195                 200                 205            
 Arg Thr Ala Ile Pro Asn Met Asp Arg Glu Thr Gln Glu Glu Phe Leu
     210                 215                 220                
 Val Val Ile Gln Ala Lys Asp Met Gly Gly His Met Gly Gly Leu Ser
 225                 230                 235                 240
 Gly Ser Thr Thr Val Thr Val Thr Leu Ser Asp Val Asn Asp Asn Pro
                 245                 250                 255    
 Pro Lys Phe Pro Gln Ser Leu Tyr Gln Phe Ser Val Val Glu Thr Ala
             260                 265                 270        
 Gly Pro Gly Thr Leu Val Gly Arg Leu Arg Ala Gln Asp Pro Asp Leu
         275                 280                 285            
 Gly Asp Asn Ala Leu Met Ala Tyr Ser Ile Leu Asp Gly Glu Gly Ser
     290                 295                 300                
 Glu Ala Phe Ser Ile Ser Thr Asp Leu Gln Gly Arg Asp Gly Leu Leu
 305                 310                 315                 320
 Thr Val Arg Lys Pro Leu Asp Phe Glu Ser Gln Arg Ser Tyr Ser Phe
                 325                 330                 335    
 Arg Val Glu Ala Thr Asn Thr Leu Ile Asp Pro Ala Tyr Leu Arg Arg
             340                 345                 350        
 Gly Pro Phe Lys Asp Val Ala Ser Val Arg Val Ala Val Gln Asp Ala
         355                 360                 365            
 Pro Glu Pro Pro Ala Phe Thr Gln Ala Ala Tyr His Leu Thr Val Pro
     370                 375                 380                
 Glu Asn Lys Ala Pro Gly Thr Leu Val Gly Gln Ile Ser Ala Ala Asp
 385                 390                 395                 400
 Leu Asp Ser Pro Ala Ser Pro Ile Arg Tyr Ser Ile Leu Pro His Ser
                 405                 410                 415    
 Asp Pro Glu Arg Cys Phe Ser Ile Gln Pro Glu Glu Gly Thr Ile His
             420                 425                 430        
 Thr Ala Ala Pro Leu Asp Arg Glu Ala Arg Ala Trp His Asn Leu Thr
         435                 440                 445            
 Val Leu Ala Thr Glu Leu Gly Trp Ser Trp Gly Pro Glu Arg Gly Trp
     450                 455                 460                
 Val Pro Leu Leu Val Ala Glu Trp Ser Ala Pro Ala Ala Pro Pro Gln
 465                 470                 475                 480
 Arg Ser Pro Val Gly Ser Ala Val Gly Ile Pro Gln Asp Ser Ser Ala
                 485                 490                 495    
 Gln Ala Ser Arg Val Gln Val Ala Ile Gln Thr Leu Asp Glu Asn Asp
             500                 505                 510        
 Asn Ala Pro Gln Leu Ala Glu Pro Tyr Asp Thr Phe Val Cys Asp Ser
         515                 520                 525            
 Ala Ala Pro Gly Gln Leu Ile Gln Val Ile Arg Ala Leu Asp Arg Asp
     530                 535                 540                
 Glu Val Gly Asn Ser Ser His Val Ser Phe Gln Gly Pro Leu Gly Pro
 545                 550                 555                 560
 Asp Ala Asn Phe Thr Val Gln Asp Asn Arg Asp Leu Pro Ala Trp Phe
                 565                 570                 575    
 His Pro Leu Leu Met Ala Ser Ala Ser Ser Trp Leu His Trp Pro Pro
             580                 585                 590        
 Ala Glu Arg Gly Asn Gln Pro Ala Ser Gln Gly Lys Ser Ser Ser Leu
         595                 600                 605            
 Pro Cys Gly Arg Leu Pro Gly Ala Leu Pro Ser Cys Gln Leu Pro Leu
     610                 615                 620                
 Gly Ile Pro Ala Leu Gly Ile Val Leu Cys Ala Ser
 625                 630                 635    



      <210> 1029
      <211> 598
      <212> PRT
      <213> Homo sapiens


      <400> 1029
 Met Trp Gly Leu Val Arg Leu Leu Leu Ala Trp Leu Gly Gly Trp Gly
   1               5                  10                  15    
 Cys Met Gly Arg Leu Ala Ala Pro Ala Arg Ala Trp Ala Gly Ser Arg
              20                  25                  30        
 Glu His Pro Gly Pro Ala Leu Leu Arg Thr Arg Arg Ser Trp Val Trp
          35                  40                  45            
 Asn Gln Phe Phe Val Ile Glu Glu Tyr Ala Gly Pro Glu Pro Val Leu
      50                  55                  60                
 Ile Gly Lys Leu His Ser Asp Val Asp Arg Gly Glu Gly Arg Thr Lys
  65                  70                  75                  80
 Tyr Leu Leu Thr Gly Glu Gly Ala Gly Thr Val Phe Val Ile Asp Glu
                  85                  90                  95    
 Ala Thr Gly Asn Ile His Val Thr Lys Ser Leu Asp Arg Glu Glu Lys
             100                 105                 110        
 Ala Gln Tyr Val Leu Leu Ala Gln Ala Val Asp Arg Ala Ser Asn Arg
         115                 120                 125            
 Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Gly Gln Asp Ile Asn
     130                 135                 140                
 Asp Asn Pro Pro Ile Phe Pro Leu Gly Pro Tyr His Ala Thr Val Pro
 145                 150                 155                 160
 Glu Met Ser Asn Val Gly Thr Ser Val Ile Gln Val Thr Ala His Asp
                 165                 170                 175    
 Ala Asp Asp Pro Ser Tyr Gly Asn Ser Ala Lys Leu Val Tyr Thr Val
             180                 185                 190        
 Leu Asp Gly Leu Pro Phe Phe Ser Val Asp Pro Gln Thr Gly Val Val
         195                 200                 205            
 Arg Thr Ala Ile Pro Asn Met Asp Arg Glu Thr Gln Glu Glu Phe Leu
     210                 215                 220                
 Val Val Ile Gln Ala Lys Asp Met Gly Gly His Met Gly Gly Leu Ser
 225                 230                 235                 240
 Gly Ser Thr Thr Val Thr Val Thr Leu Ser Asp Val Asn Asp Asn Pro
                 245                 250                 255    
 Pro Lys Phe Pro Gln Ser Leu Tyr Gln Phe Ser Val Val Glu Thr Ala
             260                 265                 270        
 Gly Pro Gly Thr Leu Val Gly Arg Leu Arg Ala Gln Asp Pro Asp Leu
         275                 280                 285            
 Gly Asp Asn Ala Leu Met Ala Tyr Ser Ile Leu Asp Gly Glu Gly Ser
     290                 295                 300                
 Glu Ala Phe Ser Ile Ser Thr Asp Leu Gln Gly Arg Asp Gly Leu Leu
 305                 310                 315                 320
 Thr Val Arg Lys Pro Leu Asp Phe Glu Ser Gln Arg Ser Tyr Ser Phe
                 325                 330                 335    
 Arg Val Glu Ala Thr Asn Thr Leu Ile Asp Pro Ala Tyr Leu Arg Arg
             340                 345                 350        
 Gly Pro Phe Lys Asp Val Ala Ser Val Arg Val Ala Val Gln Asp Ala
         355                 360                 365            
 Pro Glu Pro Pro Ala Phe Thr Gln Ala Ala Tyr His Leu Thr Val Pro
     370                 375                 380                
 Glu Asn Lys Ala Pro Gly Thr Leu Val Gly Gln Ile Ser Ala Ala Asp
 385                 390                 395                 400
 Leu Asp Ser Pro Ala Ser Pro Ile Arg Tyr Ser Ile Leu Pro His Ser
                 405                 410                 415    
 Asp Pro Glu Arg Cys Phe Ser Ile Gln Pro Glu Glu Gly Thr Ile His
             420                 425                 430        
 Thr Ala Ala Pro Leu Asp Arg Glu Ala Arg Ala Trp His Asn Leu Thr
         435                 440                 445            
 Val Leu Ala Thr Glu Leu Asp Ser Ser Ala Gln Ala Ser Arg Val Gln
     450                 455                 460                
 Val Ala Ile Gln Thr Leu Asp Glu Asn Asp Asn Ala Pro Gln Leu Ala
 465                 470                 475                 480
 Glu Pro Tyr Asp Thr Phe Val Cys Asp Ser Ala Ala Pro Gly Gln Leu
                 485                 490                 495    
 Ile Gln Val Ile Arg Ala Leu Asp Arg Asp Glu Val Gly Asn Ser Ser
             500                 505                 510        
 His Val Ser Phe Gln Gly Pro Leu Gly Pro Asp Ala Asn Phe Thr Val
         515                 520                 525            
 Gln Asp Asn Arg Asp Leu Pro Ala Trp Phe His Pro Leu Leu Met Ala
     530                 535                 540                
 Ser Ala Ser Ser Trp Leu His Trp Pro Pro Ala Glu Arg Gly Asn Gln
 545                 550                 555                 560
 Pro Ala Ser Gln Gly Lys Ser Ser Ser Leu Pro Cys Gly Arg Leu Pro
                 565                 570                 575    
 Gly Ala Leu Pro Ser Cys Gln Leu Pro Leu Gly Ile Pro Ala Leu Gly
             580                 585                 590        
 Ile Val Leu Cys Ala Ser
         595            



      <210> 1030
      <211> 1353
      <212> PRT
      <213> Homo sapiens


      <400> 1030
 Met Leu Asp Pro Ser Ser Ser Glu Glu Glu Ser Asp Glu Ile Val Glu
   1               5                  10                  15    
 Glu Glu Ser Gly Lys Glu Val Leu Gly Ser Ala Pro Ser Gly Ala Arg
              20                  25                  30        
 Leu Ser Pro Ser Arg Thr Ser Glu Gly Ser Ala Gly Ser Ala Gly Leu
          35                  40                  45            
 Gly Gly Gly Gly Ala Gly Ala Gly Ala Gly Val Gly Ala Gly Gly Gly
      50                  55                  60                
 Gly Gly Ser Gly Ala Ser Ser Gly Gly Gly Ala Gly Gly Leu Gln Pro
  65                  70                  75                  80
 Ser Ser Arg Ala Gly Gly Gly Arg Pro Ser Ser Pro Ser Pro Ser Val
                  85                  90                  95    
 Val Ser Glu Lys Glu Lys Glu Glu Leu Glu Arg Leu Gln Lys Glu Glu
             100                 105                 110        
 Glu Glu Arg Lys Lys Arg Leu Gln Leu Tyr Val Phe Val Met Arg Cys
         115                 120                 125            
 Ile Ala Tyr Pro Phe Asn Ala Lys Gln Pro Thr Asp Met Ala Arg Arg
     130                 135                 140                
 Gln Gln Lys Ile Ser Lys Gln Gln Leu Gln Thr Val Lys Asp Arg Phe
 145                 150                 155                 160
 Gln Ala Phe Leu Asn Gly Glu Thr Gln Ile Met Ala Asp Glu Ala Phe
                 165                 170                 175    
 Met Asn Ala Val Gln Ser Tyr Tyr Glu Val Phe Leu Lys Ser Asp Arg
             180                 185                 190        
 Val Ala Arg Met Val Gln Ser Gly Gly Cys Ser Ala Asn Asp Ser Arg
         195                 200                 205            
 Glu Val Phe Lys Lys His Ile Glu Lys Arg Val Arg Ser Leu Pro Glu
     210                 215                 220                
 Ile Asp Gly Leu Ser Lys Glu Thr Val Leu Ser Ser Trp Met Ala Lys
 225                 230                 235                 240
 Phe Asp Ala Ile Tyr Arg Gly Glu Glu Asp Pro Arg Lys Gln Gln Ala
                 245                 250                 255    
 Arg Met Thr Ala Ser Ala Ala Ser Glu Leu Ile Leu Ser Lys Glu Gln
             260                 265                 270        
 Leu Tyr Glu Met Phe Gln Asn Ile Leu Gly Ile Lys Lys Phe Glu His
         275                 280                 285            
 Gln Leu Leu Tyr Asn Ala Cys Gln Leu Asp Asn Pro Asp Glu Gln Ala
     290                 295                 300                
 Ala Gln Ile Arg Arg Glu Leu Asp Gly Arg Leu Gln Met Ala Asp Gln
 305                 310                 315                 320
 Ile Ala Arg Glu Arg Lys Phe Pro Lys Phe Val Ser Lys Glu Met Glu
                 325                 330                 335    
 Asn Met Tyr Ile Glu Glu Leu Lys Ser Ser Val Asn Leu Leu Met Ala
             340                 345                 350        
 Asn Leu Glu Ser Met Pro Val Ser Lys Gly Gly Glu Phe Lys Leu Gln
         355                 360                 365            
 Lys Leu Lys Arg Ser His Asn Ala Ser Ile Ile Asp Met Gly Glu Glu
     370                 375                 380                
 Ser Glu Asn Gln Leu Ser Lys Ser Asp Val Val Leu Ser Phe Ser Leu
 385                 390                 395                 400
 Glu Val Val Ile Met Glu Val Gln Gly Leu Lys Ser Leu Ala Pro Asn
                 405                 410                 415    
 Arg Ile Val Tyr Cys Thr Met Glu Val Glu Gly Gly Glu Lys Leu Gln
             420                 425                 430        
 Thr Asp Gln Ala Glu Ala Ser Lys Pro Thr Trp Gly Thr Gln Gly Asp
         435                 440                 445            
 Phe Ser Thr Thr His Ala Leu Pro Ala Val Lys Val Lys Leu Phe Thr
     450                 455                 460                
 Glu Ser Thr Gly Val Leu Ala Leu Glu Asp Lys Glu Leu Gly Arg Val
 465                 470                 475                 480
 Ile Leu His Pro Thr Pro Asn Ser Pro Lys Gln Ser Glu Trp His Lys
                 485                 490                 495    
 Met Thr Val Ser Lys Asn Cys Pro Asp Gln Asp Leu Lys Ile Lys Leu
             500                 505                 510        
 Ala Val Arg Met Asp Lys Pro Gln Asn Met Lys His Ser Gly Tyr Leu
         515                 520                 525            
 Trp Ala Ile Gly Lys Asn Val Trp Lys Arg Trp Lys Lys Arg Phe Phe
     530                 535                 540                
 Val Leu Val Gln Val Ser Gln Tyr Thr Phe Ala Met Cys Ser Tyr Arg
 545                 550                 555                 560
 Glu Lys Lys Ala Glu Pro Gln Glu Leu Leu Gln Leu Asp Gly Tyr Thr
                 565                 570                 575    
 Val Asp Tyr Thr Asp Pro Gln Pro Gly Leu Glu Gly Gly Arg Ala Phe
             580                 585                 590        
 Phe Asn Ala Val Lys Glu Gly Asp Thr Val Ile Phe Ala Ser Asp Asp
         595                 600                 605            
 Glu Gln Asp Arg Ile Leu Trp Val Gln Ala Met Tyr Arg Ala Thr Gly
     610                 615                 620                
 Gln Ser His Lys Pro Val Pro Pro Thr Gln Val Gln Lys Leu Asn Ala
 625                 630                 635                 640
 Lys Gly Gly Asn Val Pro Gln Leu Asp Ala Pro Ile Ser Gln Phe Tyr
                 645                 650                 655    
 Ala Asp Arg Ala Gln Lys His Gly Met Asp Glu Phe Ile Ser Ser Asn
             660                 665                 670        
 Pro Cys Asn Phe Asp His Ala Ser Leu Phe Glu Met Val Gln Arg Leu
         675                 680                 685            
 Thr Leu Asp His Arg Leu Asn Asp Ser Tyr Ser Cys Leu Gly Trp Phe
     690                 695                 700                
 Ser Pro Gly Gln Val Phe Val Leu Asp Glu Tyr Cys Ala Arg Asn Gly
 705                 710                 715                 720
 Val Arg Gly Cys His Arg His Leu Cys Tyr Leu Arg Asp Leu Leu Glu
                 725                 730                 735    
 Arg Ala Glu Asn Gly Ala Met Ile Asp Pro Thr Leu Leu His Tyr Ser
             740                 745                 750        
 Phe Ala Phe Cys Ala Ser His Val His Gly Asn Arg Pro Asp Gly Ile
         755                 760                 765            
 Gly Thr Val Thr Val Glu Glu Lys Glu Arg Phe Glu Glu Ile Lys Glu
     770                 775                 780                
 Arg Leu Arg Val Leu Leu Glu Asn Gln Ile Thr His Phe Arg Tyr Cys
 785                 790                 795                 800
 Phe Pro Phe Gly Arg Pro Glu Gly Ala Leu Lys Ala Thr Leu Ser Leu
                 805                 810                 815    
 Leu Glu Arg Val Leu Met Lys Asp Ile Val Thr Pro Val Pro Gln Glu
             820                 825                 830        
 Glu Val Lys Thr Val Ile Arg Lys Cys Leu Glu Gln Ala Ala Leu Val
         835                 840                 845            
 Asn Tyr Ser Arg Leu Ser Glu Tyr Ala Lys Ile Glu Glu Asn Gln Lys
     850                 855                 860                
 Asp Ala Glu Asn Val Gly Arg Leu Ile Thr Pro Ala Lys Lys Leu Glu
 865                 870                 875                 880
 Asp Thr Ile Arg Leu Ala Glu Leu Val Ile Glu Val Leu Gln Gln Asn
                 885                 890                 895    
 Glu Glu His His Ala Glu Pro His Val Asp Lys Gly Glu Ala Phe Ala
             900                 905                 910        
 Trp Trp Ser Asp Leu Met Val Glu His Ala Glu Thr Phe Leu Ser Leu
         915                 920                 925            
 Phe Ala Val Asp Met Asp Ala Ala Leu Glu Val Gln Pro Pro Asp Thr
     930                 935                 940                
 Trp Asp Ser Phe Pro Leu Phe Gln Leu Leu Asn Asp Phe Leu Arg Thr
 945                 950                 955                 960
 Asp Tyr Asn Leu Cys Asn Gly Lys Phe His Lys His Leu Gln Asp Leu
                 965                 970                 975    
 Phe Ala Pro Leu Val Val Arg Tyr Val Asp Leu Met Glu Ser Ser Ile
             980                 985                 990        
 Ala Gln Ser Ile His Arg Gly Phe Glu Arg Glu Ser Trp Glu Pro Val
         995                1000                1005            
 Lys Ser Leu Thr Ser Asn Leu Pro Asn Val Asn Leu Pro Asn Val Asn
    1010                1015                1020                
 Leu Pro Lys Val Pro Asn Leu Pro Val Asn Ile Pro Leu Gly Ile Pro
1025                1030                1035                1040
 Gln Met Pro Thr Phe Ser Ala Pro Ser Trp Met Ala Ala Ile Tyr Asp
                1045                1050                1055    
 Ala Asp Asn Gly Ser Gly Thr Ser Glu Asp Leu Phe Trp Lys Leu Asp
            1060                1065                1070        
 Ala Leu Gln Thr Phe Ile Arg Asp Leu His Trp Pro Glu Glu Glu Phe
        1075                1080                1085            
 Gly Lys His Leu Glu Gln Arg Leu Lys Leu Met Ala Ser Asp Met Ile
    1090                1095                1100                
 Glu Ser Cys Val Lys Arg Thr Arg Ile Ala Phe Glu Val Lys Leu Gln
1105                1110                1115                1120
 Lys Thr Ser Arg Ser Thr Asp Phe Arg Val Pro Gln Ser Ile Cys Thr
                1125                1130                1135    
 Met Phe Asn Val Met Val Asp Ala Lys Ala Gln Ser Thr Lys Leu Cys
            1140                1145                1150        
 Ser Met Glu Met Gly Gln Glu His Gln Tyr His Ser Lys Ile Asp Glu
        1155                1160                1165            
 Leu Ile Glu Glu Thr Val Lys Glu Met Ile Thr Leu Leu Val Ala Lys
    1170                1175                1180                
 Phe Val Thr Ile Leu Glu Gly Val Leu Ala Lys Leu Ser Arg Tyr Asp
1185                1190                1195                1200
 Glu Gly Thr Leu Phe Ser Ser Phe Leu Ser Phe Thr Val Lys Ala Ala
                1205                1210                1215    
 Ser Lys Tyr Val Asp Val Pro Lys Pro Gly Met Asp Val Ala Asp Ala
            1220                1225                1230        
 Tyr Val Thr Phe Val Arg His Ser Gln Asp Val Leu Arg Asp Lys Val
        1235                1240                1245            
 Asn Glu Glu Met Tyr Ile Glu Arg Leu Phe Asp Gln Trp Tyr Asn Ser
    1250                1255                1260                
 Ser Met Asn Val Ile Cys Thr Trp Leu Thr Asp Arg Met Asp Leu Gln
1265                1270                1275                1280
 Leu His Ile Tyr Gln Leu Lys Thr Leu Ile Arg Val Val Lys Lys Thr
                1285                1290                1295    
 Tyr Arg Asp Phe Arg Leu Gln Gly Val Leu Asp Ser Thr Leu Asn Ser
            1300                1305                1310        
 Lys Thr Tyr Glu Thr Ile Arg Asn Arg Leu Thr Val Glu Glu Ala Thr
        1315                1320                1325            
 Ala Ser Val Ser Glu Gly Gly Gly Leu Gln Gly Ile Ser Met Lys Asp
    1330                1335                1340                
 Ser Asp Glu Glu Asp Glu Glu Asp Asp
1345                1350            



      <210> 1031
      <211> 376
      <212> PRT
      <213> Homo sapiens


      <400> 1031
 Met Gln Pro Ser Gly Leu Glu Gly Pro Gly Thr Phe Gly Arg Trp Pro
   1               5                  10                  15    
 Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Val Thr Cys
              20                  25                  30        
 Ala Tyr Thr Thr Pro Gly Pro Pro Arg Ala Leu Thr Thr Leu Gly Ala
          35                  40                  45            
 Pro Arg Ala His Thr Met Pro Gly Thr Tyr Ala Pro Ser Thr Thr Leu
      50                  55                  60                
 Ser Ser Pro Ser Thr Gln Gly Leu Gln Glu Gln Ala Arg Ala Leu Met
  65                  70                  75                  80
 Arg Asp Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro Leu Val Leu
                  85                  90                  95    
 Arg Gln Val Tyr Gln Lys Gly Leu Gln Asp Val Asn Leu Arg Asn Phe
             100                 105                 110        
 Ser Tyr Gly Gln Thr Ser Leu Asp Arg Leu Arg Asp Gly Leu Val Gly
         115                 120                 125            
 Ala Gln Phe Trp Ser Ala Tyr Val Pro Cys Gln Thr Gln Asp Arg Asp
     130                 135                 140                
 Ala Leu Arg Leu Thr Leu Glu Gln Ile Asp Leu Ile Arg Arg Met Cys
 145                 150                 155                 160
 Ala Ser Tyr Ser Glu Leu Glu Leu Val Thr Ser Ala Lys Ala Leu Asn
                 165                 170                 175    
 Asp Thr Gln Lys Leu Ala Cys Leu Ile Gly Val Glu Gly Gly His Ser
             180                 185                 190        
 Leu Asp Asn Ser Leu Ser Ile Leu Arg Thr Phe Tyr Met Leu Gly Val
         195                 200                 205            
 Arg Tyr Leu Thr Leu Thr His Thr Cys Asn Thr Pro Trp Ala Glu Ser
     210                 215                 220                
 Ser Ala Lys Gly Val His Ser Phe Tyr Asn Asn Ile Ser Gly Leu Thr
 225                 230                 235                 240
 Asp Phe Gly Glu Lys Val Val Ala Glu Met Asn Arg Leu Gly Met Met
                 245                 250                 255    
 Val Asp Leu Ser His Val Ser Asp Ala Val Ala Arg Arg Ala Leu Glu
             260                 265                 270        
 Val Ser Gln Ala Pro Val Ile Phe Ser His Ser Ala Ala Arg Gly Val
         275                 280                 285            
 Cys Asn Ser Ala Arg Asn Val Pro Asp Asp Ile Leu Gln Leu Leu Lys
     290                 295                 300                
 Lys Asn Gly Gly Val Val Met Val Ser Leu Ser Met Gly Val Ile Gln
 305                 310                 315                 320
 Cys Asn Pro Ser Ala Asn Val Ser Thr Val Ala Asp His Phe Asp His
                 325                 330                 335    
 Ile Lys Ala Val Ile Gly Ser Lys Phe Ile Gly Ile Gly Gly Asp Tyr
             340                 345                 350        
 Asp Gly Ala Gly Lys Tyr Arg Lys Lys Thr Lys Cys Lys Ala Pro Trp
         355                 360                 365            
 Arg Thr Ser Ser Arg Met Ser Ser
     370                 375    



      <210> 1032
      <211> 501
      <212> PRT
      <213> Homo sapiens


      <400> 1032
 Met Val Arg Lys Pro Val Val Ser Thr Ile Ser Lys Gly Gly Tyr Leu
   1               5                  10                  15    
 Gln Gly Asn Val Asn Gly Arg Leu Pro Ser Leu Gly Asn Lys Glu Pro
              20                  25                  30        
 Pro Gly Gln Glu Lys Val Gln Leu Lys Arg Lys Val Thr Leu Leu Arg
          35                  40                  45            
 Gly Val Ser Ile Ile Ile Gly Thr Ile Ile Gly Ala Gly Ile Phe Ile
      50                  55                  60                
 Ser Pro Lys Gly Val Leu Gln Asn Thr Gly Ser Val Gly Met Ser Leu
  65                  70                  75                  80
 Thr Ile Trp Thr Val Cys Gly Val Leu Ser Leu Phe Gly Ala Leu Ser
                  85                  90                  95    
 Tyr Ala Glu Leu Gly Thr Thr Ile Lys Lys Ser Gly Gly His Tyr Thr
             100                 105                 110        
 Tyr Ile Leu Glu Val Phe Gly Pro Leu Pro Ala Phe Val Arg Val Trp
         115                 120                 125            
 Val Glu Leu Leu Ile Ile Arg Pro Ala Ala Thr Ala Val Ile Ser Leu
     130                 135                 140                
 Ala Phe Gly Arg Tyr Ile Leu Glu Pro Phe Phe Ile Gln Cys Glu Ile
 145                 150                 155                 160
 Pro Glu Leu Ala Ile Lys Leu Ile Thr Ala Val Gly Ile Thr Val Val
                 165                 170                 175    
 Met Val Leu Asn Ser Met Ser Val Ser Trp Ser Ala Arg Ile Gln Ile
             180                 185                 190        
 Phe Leu Thr Phe Cys Lys Leu Thr Ala Ile Leu Ile Ile Ile Val Pro
         195                 200                 205            
 Gly Val Met Gln Leu Ile Lys Gly Gln Thr Gln Asn Phe Lys Asp Ala
     210                 215                 220                
 Phe Ser Gly Arg Asp Ser Ser Ile Thr Arg Leu Pro Leu Ala Phe Tyr
 225                 230                 235                 240
 Tyr Gly Met Tyr Ala Tyr Ala Gly Trp Phe Tyr Leu Asn Phe Val Thr
                 245                 250                 255    
 Glu Glu Val Glu Asn Pro Glu Lys Thr Ile Pro Leu Ala Ile Cys Ile
             260                 265                 270        
 Ser Met Ala Ile Val Thr Ile Gly Tyr Val Leu Thr Asn Val Ala Tyr
         275                 280                 285            
 Phe Thr Thr Ile Asn Ala Glu Glu Leu Leu Leu Ser Asn Ala Val Ala
     290                 295                 300                
 Val Thr Phe Ser Glu Arg Leu Leu Gly Asn Phe Ser Leu Ala Val Pro
 305                 310                 315                 320
 Ile Phe Val Ala Leu Ser Cys Phe Gly Ser Met Asn Gly Gly Val Phe
                 325                 330                 335    
 Ala Val Ser Arg Leu Phe Tyr Val Ala Ser Arg Glu Gly His Leu Pro
             340                 345                 350        
 Glu Ile Leu Ser Met Ile His Val Arg Lys His Thr Pro Leu Pro Ala
         355                 360                 365            
 Val Ile Val Leu His Pro Leu Thr Met Ile Met Leu Phe Ser Gly Asp
     370                 375                 380                
 Leu Asp Ser Leu Leu Asn Phe Leu Ser Phe Ala Arg Trp Leu Phe Ile
 385                 390                 395                 400
 Gly Leu Ala Val Ala Gly Leu Ile Tyr Leu Arg Tyr Lys Cys Pro Asp
                 405                 410                 415    
 Met His Arg Pro Phe Lys Val Pro Leu Phe Ile Pro Ala Leu Phe Ser
             420                 425                 430        
 Phe Thr Cys Leu Phe Met Val Ala Leu Ser Leu Tyr Ser Asp Pro Phe
         435                 440                 445            
 Ser Thr Gly Ile Gly Phe Val Ile Thr Leu Thr Gly Val Pro Ala Tyr
     450                 455                 460                
 Tyr Leu Phe Ile Ile Trp Asp Lys Lys Pro Arg Trp Phe Arg Ile Met
 465                 470                 475                 480
 Ser Glu Lys Ile Thr Arg Thr Leu Gln Ile Ile Leu Glu Val Val Pro
                 485                 490                 495    
 Glu Glu Asp Lys Leu
             500    



      <210> 1033
      <211> 979
      <212> PRT
      <213> Homo sapiens


      <400> 1033
 Met Gly Thr Arg Leu Pro Leu Val Leu Arg Gln Leu Arg Arg Pro Pro
   1               5                  10                  15    
 Gln Pro Pro Gly Pro Pro Arg Arg Leu Arg Val Pro Cys Arg Ala Ser
              20                  25                  30        
 Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Glu Gly Leu Leu Gly
          35                  40                  45            
 Gln Arg Arg Pro Gln Asp Gly Gln Ala Arg Ser Ser Cys Ser Pro Gly
      50                  55                  60                
 Gly Arg Thr Pro Ala Ala Arg Asp Ser Ile Val Arg Glu Val Ile Gln
  65                  70                  75                  80
 Asn Ser Lys Glu Val Leu Ser Leu Leu Gln Glu Lys Asn Pro Ala Phe
                  85                  90                  95    
 Lys Pro Val Leu Ala Ile Ile Gln Ala Gly Asp Asp Asn Leu Met Gln
             100                 105                 110        
 Glu Ile Asn Gln Asn Leu Ala Glu Glu Ala Gly Leu Asn Ile Thr His
         115                 120                 125            
 Ile Cys Leu Pro Pro Asp Ser Ser Glu Ala Glu Ile Ile Asp Glu Ile
     130                 135                 140                
 Leu Lys Ile Asn Glu Asp Thr Arg Val His Gly Leu Ala Leu Gln Ile
 145                 150                 155                 160
 Ser Glu Asn Leu Phe Ser Asn Lys Val Leu Asn Ala Leu Lys Pro Glu
                 165                 170                 175    
 Lys Asp Val Asp Gly Val Thr Asp Ile Asn Leu Gly Lys Leu Val Arg
             180                 185                 190        
 Gly Asp Ala His Glu Cys Phe Val Ser Pro Val Ala Lys Ala Val Ile
         195                 200                 205            
 Glu Leu Leu Glu Lys Ser Val Gly Val Asn Leu Asp Gly Lys Lys Ile
     210                 215                 220                
 Leu Val Val Gly Ala His Gly Ser Leu Glu Ala Ala Leu Gln Cys Leu
 225                 230                 235                 240
 Phe Gln Arg Lys Gly Ser Met Thr Met Ser Ile Gln Trp Lys Thr Arg
                 245                 250                 255    
 Gln Leu Gln Ser Lys Leu His Glu Ala Asp Ile Val Val Leu Gly Ser
             260                 265                 270        
 Pro Lys Pro Glu Glu Ile Pro Leu Thr Trp Ile Gln Pro Gly Thr Thr
         275                 280                 285            
 Val Leu Asn Cys Ser His Asp Phe Leu Ser Gly Lys Val Gly Cys Gly
     290                 295                 300                
 Ser Pro Arg Ile His Phe Gly Gly Leu Ile Glu Glu Asp Asp Val Ile
 305                 310                 315                 320
 Leu Leu Ala Ala Ala Leu Arg Ile Gln Asn Met Val Ser Ser Gly Arg
                 325                 330                 335    
 Arg Trp Leu Arg Glu Gln Gln His Arg Arg Trp Arg Leu His Cys Leu
             340                 345                 350        
 Lys Leu Gln Pro Leu Ser Pro Val Pro Ser Asp Ile Glu Ile Ser Arg
         355                 360                 365            
 Gly Gln Thr Pro Lys Ala Val Asp Val Leu Ala Lys Glu Ile Gly Leu
     370                 375                 380                
 Leu Ala Asp Glu Ile Glu Ile Tyr Gly Lys Ser Lys Ala Lys Val Arg
 385                 390                 395                 400
 Leu Ser Val Leu Glu Arg Leu Lys Asp Gln Ala Asp Gly Lys Tyr Val
                 405                 410                 415    
 Leu Val Ala Gly Ile Thr Pro Thr Pro Leu Gly Glu Gly Lys Ser Thr
             420                 425                 430        
 Val Thr Ile Gly Leu Val Gln Ala Leu Thr Ala His Leu Asn Val Asn
         435                 440                 445            
 Ser Phe Ala Cys Leu Arg Gln Pro Ser Gln Gly Pro Thr Phe Gly Val
     450                 455                 460                
 Lys Gly Gly Ala Ala Gly Gly Gly Tyr Ala Gln Val Ile Pro Met Glu
 465                 470                 475                 480
 Glu Phe Asn Leu His Leu Thr Gly Asp Ile His Ala Ile Thr Ala Ala
                 485                 490                 495    
 Asn Asn Leu Leu Ala Ala Ala Ile Asp Thr Arg Ile Leu His Glu Asn
             500                 505                 510        
 Thr Gln Thr Asp Lys Ala Leu Tyr Asn Arg Leu Val Pro Leu Val Asn
         515                 520                 525            
 Gly Val Arg Glu Phe Ser Glu Ile Gln Leu Ala Arg Leu Lys Lys Leu
     530                 535                 540                
 Gly Ile Asn Lys Thr Asp Pro Ser Thr Leu Thr Glu Glu Glu Val Ser
 545                 550                 555                 560
 Lys Phe Ala Arg Leu Asp Ile Asp Pro Ser Thr Ile Thr Trp Gln Arg
                 565                 570                 575    
 Val Leu Asp Thr Asn Asp Arg Phe Leu Arg Lys Ile Thr Ile Gly Gln
             580                 585                 590        
 Gly Asn Thr Glu Lys Gly His Tyr Arg Gln Ala Gln Phe Asp Ile Ala
         595                 600                 605            
 Val Ala Ser Glu Ile Met Ala Val Leu Ala Leu Thr Asp Ser Leu Ala
     610                 615                 620                
 Asp Met Lys Ala Arg Leu Gly Arg Met Val Val Ala Ser Asp Lys Ser
 625                 630                 635                 640
 Gly Gln Pro Val Thr Ala Asp Asp Leu Gly Val Thr Gly Ala Leu Thr
                 645                 650                 655    
 Val Leu Met Lys Asp Ala Ile Lys Pro Asn Leu Met Gln Thr Leu Glu
             660                 665                 670        
 Gly Thr Pro Val Phe Val His Ala Gly Pro Phe Ala Asn Ile Ala His
         675                 680                 685            
 Gly Asn Ser Ser Val Leu Ala Asp Lys Ile Ala Leu Lys Leu Val Gly
     690                 695                 700                
 Glu Glu Gly Phe Val Val Thr Glu Ala Gly Phe Gly Ala Asp Ile Gly
 705                 710                 715                 720
 Met Glu Lys Phe Phe Asn Ile Lys Cys Arg Ala Ser Gly Leu Val Pro
                 725                 730                 735    
 Asn Val Val Val Leu Val Ala Thr Val Arg Ala Leu Lys Met His Gly
             740                 745                 750        
 Gly Gly Pro Ser Val Thr Ala Gly Val Pro Leu Lys Lys Glu Tyr Thr
         755                 760                 765            
 Glu Glu Asn Ile Gln Leu Val Ala Asp Gly Cys Cys Asn Leu Gln Lys
     770                 775                 780                
 Gln Ile Gln Ile Thr Gln Leu Phe Gly Val Pro Val Val Val Ala Leu
 785                 790                 795                 800
 Asn Val Phe Lys Thr Asp Thr Arg Ala Glu Ile Asp Leu Val Cys Glu
                 805                 810                 815    
 Leu Ala Lys Arg Ala Gly Ala Phe Asp Ala Val Pro Cys Tyr His Trp
             820                 825                 830        
 Ser Val Gly Gly Lys Gly Ser Val Asp Leu Ala Arg Ala Val Arg Glu
         835                 840                 845            
 Ala Ala Ser Lys Arg Ser Arg Phe Gln Phe Leu Tyr Asp Val Gln Val
     850                 855                 860                
 Pro Ile Val Asp Lys Ile Arg Thr Ile Ala Gln Ala Val Tyr Gly Ala
 865                 870                 875                 880
 Lys Asp Ile Glu Leu Ser Pro Glu Ala Gln Ala Lys Ile Asp Arg Tyr
                 885                 890                 895    
 Thr Gln Gln Gly Phe Gly Asn Leu Pro Ile Cys Met Ala Lys Thr His
             900                 905                 910        
 Leu Ser Leu Ser His Gln Pro Asp Lys Lys Gly Val Pro Arg Asp Phe
         915                 920                 925            
 Ile Leu Pro Ile Ser Asp Val Arg Ala Ser Ile Gly Ala Gly Phe Ile
     930                 935                 940                
 Tyr Pro Leu Val Gly Thr Met Ser Thr Met Pro Gly Leu Pro Thr Arg
 945                 950                 955                 960
 Pro Cys Phe Tyr Asp Ile Asp Leu Asp Thr Glu Thr Glu Gln Val Lys
                 965                 970                 975    
 Gly Leu Phe
            



      <210> 1034
      <211> 1243
      <212> PRT
      <213> Homo sapiens


      <400> 1034
 Met Ser Glu Ala Pro Arg Phe Phe Val Gly Pro Glu Asp Thr Glu Ile
   1               5                  10                  15    
 Asn Pro Gly Asn Tyr Arg His Phe Phe His His Ala Asp Glu Asp Asp
              20                  25                  30        
 Glu Glu Glu Asp Asp Ser Pro Pro Glu Arg Gln Ile Val Val Gly Ile
          35                  40                  45            
 Cys Ser Met Ala Lys Lys Ser Lys Ser Lys Pro Met Lys Glu Ile Leu
      50                  55                  60                
 Glu Arg Ile Ser Leu Phe Lys Tyr Ile Thr Val Val Val Phe Glu Glu
  65                  70                  75                  80
 Glu Val Ile Leu Asn Glu Pro Val Glu Asn Trp Pro Leu Cys Asp Cys
                  85                  90                  95    
 Leu Ile Ser Phe His Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala
             100                 105                 110        
 Tyr Ala Lys Leu Arg Asn Pro Phe Val Ile Asn Asp Leu Asn Met Gln
         115                 120                 125            
 Tyr Leu Ile Gln Asp Arg Arg Glu Val Tyr Ser Ile Leu Gln Ala Glu
     130                 135                 140                
 Gly Ile Leu Leu Pro Arg Tyr Ala Ile Leu Asn Arg Asp Pro Asn Asn
 145                 150                 155                 160
 Pro Lys Glu Cys Asn Leu Ile Glu Gly Glu Asp His Val Glu Val Asn
                 165                 170                 175    
 Gly Glu Val Phe Gln Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu
             180                 185                 190        
 Asp His Asn Val Tyr Ile Tyr Tyr Pro Thr Ser Ala Gly Gly Gly Ser
         195                 200                 205            
 Gln Arg Leu Phe Arg Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro
     210                 215                 220                
 Glu Ser Asn Val Arg Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met
 225                 230                 235                 240
 Pro Thr Asp Gly Thr Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr
                 245                 250                 255    
 Ala His Ala Glu Ala Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu
             260                 265                 270        
 Arg Asp Ser Glu Gly Lys Glu Val Arg Tyr Pro Val Ile Leu Asn Ala
         275                 280                 285            
 Arg Glu Lys Leu Ile Ala Trp Lys Val Cys Leu Ala Phe Lys Gln Thr
     290                 295                 300                
 Val Cys Gly Phe Asp Leu Leu Arg Ala Asn Gly Gln Ser Tyr Val Cys
 305                 310                 315                 320
 Asp Val Asn Gly Phe Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp
                 325                 330                 335    
 Asp Cys Ala Lys Ile Leu Gly Asn Ile Val Met Arg Glu Leu Ala Pro
             340                 345                 350        
 Gln Phe His Ile Pro Trp Ser Ile Pro Leu Glu Ala Glu Asp Ile Pro
         355                 360                 365            
 Ile Val Pro Thr Thr Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile
     370                 375                 380                
 Ala Val Ile Arg His Gly Asp Arg Thr Pro Lys Lys Lys Met Lys Met
 385                 390                 395                 400
 Glu Val Arg His Gln Lys Phe Phe Asp Leu Phe Glu Lys Cys Asp Gly
                 405                 410                 415    
 Tyr Lys Ser Gly Lys Leu Lys Leu Lys Lys Pro Lys Gln Leu Gln Glu
             420                 425                 430        
 Val Leu Asp Ile Ala Arg Gln Leu Leu Met Glu Leu Gly Gln Asn Asn
         435                 440                 445            
 Asp Ser Glu Ile Glu Glu Asn Lys Pro Lys Leu Glu Gln Leu Lys Thr
     450                 455                 460                
 Val Leu Glu Met Tyr Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln
 465                 470                 475                 480
 Leu Thr Tyr Leu Pro His Gly Cys Pro Lys Thr Ser Ser Glu Glu Glu
                 485                 490                 495    
 Asp Ser Arg Arg Glu Glu Pro Ser Leu Leu Leu Val Leu Lys Trp Gly
             500                 505                 510        
 Gly Glu Leu Thr Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg
         515                 520                 525            
 Ala Phe Arg Cys Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe
     530                 535                 540                
 Pro Gly Cys Gly Leu Leu Arg Leu His Ser Thr Tyr Arg His Asp Leu
 545                 550                 555                 560
 Lys Ile Tyr Ala Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala
                 565                 570                 575    
 Phe Ala Lys Gly Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu
             580                 585                 590        
 Val Gln Met Val Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp
         595                 600                 605            
 Ser Asp Ser Leu Ser Ser Cys Gln Gln Arg Val Lys Ala Arg Leu His
     610                 615                 620                
 Glu Ile Leu Gln Lys Asp Arg Asp Phe Thr Ala Glu Asp Tyr Glu Lys
 625                 630                 635                 640
 Leu Thr Pro Ser Gly Ser Ile Ser Leu Ile Lys Ser Met His Leu Ile
                 645                 650                 655    
 Lys Asn Pro Val Lys Thr Cys Asp Lys Val Tyr Ser Leu Ile Gln Ser
             660                 665                 670        
 Leu Thr Ser Gln Ile Arg His Arg Met Glu Asp Pro Lys Ser Ser Asp
         675                 680                 685            
 Ile Gln Leu Tyr His Ser Glu Thr Leu Glu Leu Met Leu Arg Arg Trp
     690                 695                 700                
 Ser Lys Leu Glu Lys Asp Phe Lys Thr Lys Asn Gly Arg Tyr Asp Ile
 705                 710                 715                 720
 Ser Lys Ile Pro Asp Ile Tyr Asp Cys Ile Lys Tyr Asp Val Gln His
                 725                 730                 735    
 Asn Gly Ser Leu Lys Leu Glu Asn Thr Met Glu Leu Tyr Arg Leu Ser
             740                 745                 750        
 Lys Ala Leu Ala Asp Ile Val Ile Pro Gln Glu Tyr Gly Ile Thr Lys
         755                 760                 765            
 Ala Glu Lys Leu Glu Ile Ala Lys Gly Tyr Cys Thr Pro Leu Val Arg
     770                 775                 780                
 Lys Ile Arg Ser Asp Leu Gln Arg Thr Gln Asp Asp Asp Thr Val Asn
 785                 790                 795                 800
 Lys Leu His Pro Val Tyr Ser Arg Gly Val Leu Ser Pro Glu Arg His
                 805                 810                 815    
 Val Arg Thr Arg Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu
             820                 825                 830        
 Leu Ser Ile Leu Arg Tyr Gly Ala Leu Cys Asn Glu Ser Lys Asp Glu
         835                 840                 845            
 Gln Trp Lys Arg Ala Met Asp Tyr Leu Asn Val Val Asn Glu Leu Asn
     850                 855                 860                
 Tyr Met Thr Gln Ile Val Ile Met Leu Tyr Glu Asp Pro Asn Lys Asp
 865                 870                 875                 880
 Leu Ser Ser Glu Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly
                 885                 890                 895    
 Ala Lys Gly Cys Glu Glu Asp Lys Asn Leu Pro Ser Gly Tyr Gly Tyr
             900                 905                 910        
 Arg Pro Ala Ser Arg Glu Asn Glu Gly Arg Arg Pro Phe Lys Ile Asp
         915                 920                 925            
 Asn Asp Asp Glu Pro His Thr Ser Lys Arg Asp Glu Val Asp Arg Ala
     930                 935                 940                
 Val Ile Leu Phe Lys Pro Met Val Ser Glu Pro Ile His Ile His Arg
 945                 950                 955                 960
 Lys Ser Pro Leu Pro Arg Ser Arg Lys Thr Ala Thr Asn Asp Glu Glu
                 965                 970                 975    
 Ser Pro Leu Ser Val Ser Ser Pro Glu Gly Thr Gly Thr Trp Leu His
             980                 985                 990        
 Tyr Thr Ser Gly Val Gly Thr Gly Arg Arg Arg Arg Arg Ser Gly Glu
         995                1000                1005            
 Gln Ile Thr Ser Ser Pro Val Ser Pro Lys Ser Leu Ala Phe Thr Ser
    1010                1015                1020                
 Ser Ile Phe Gly Ser Trp Gln Gln Val Val Ser Glu Asn Ala Asn Tyr
1025                1030                1035                1040
 Leu Arg Thr Pro Arg Thr Leu Val Glu Gln Lys Gln Asn Pro Thr Val
                1045                1050                1055    
 Gly Ser His Cys Ala Gly Leu Phe Ser Thr Ser Val Leu Gly Gly Ser
            1060                1065                1070        
 Ser Ser Ala Pro Asn Leu Gln Asp Tyr Ala Arg Thr His Arg Lys Lys
        1075                1080                1085            
 Leu Thr Ser Ser Gly Cys Ile Asp Asp Ala Thr Arg Gly Ser Ala Val
    1090                1095                1100                
 Lys Arg Phe Ser Ile Ser Phe Ala Arg His Pro Thr Asn Gly Phe Glu
1105                1110                1115                1120
 Leu Tyr Ser Met Val Pro Ser Ile Cys Pro Leu Glu Thr Leu His Asn
                1125                1130                1135    
 Ala Leu Ser Leu Lys Gln Val Asp Glu Phe Leu Ala Ser Ile Ala Ser
            1140                1145                1150        
 Pro Ser Ser Asp Val Pro Arg Lys Thr Ala Glu Ile Ser Ser Thr Ala
        1155                1160                1165            
 Leu Arg Ser Ser Pro Ile Met Arg Lys Lys Val Ser Leu Asn Thr Tyr
    1170                1175                1180                
 Thr Pro Ala Lys Ile Leu Pro Thr Pro Pro Ala Thr Leu Lys Ser Thr
1185                1190                1195                1200
 Lys Ala Ser Ser Lys Pro Ala Thr Ser Gly Pro Ser Ser Ala Val Val
                1205                1210                1215    
 Pro Asn Thr Ser Ser Arg Lys Lys Asn Ile Thr Ser Lys Thr Glu Thr
            1220                1225                1230        
 His Glu His Lys Lys Asn Thr Gly Lys Lys Lys
        1235                1240            



      <210> 1035
      <211> 1562
      <212> PRT
      <213> Homo sapiens


      <400> 1035
 Met Ser Val Arg Leu Pro Gln Ser Ile Asp Arg Leu Ser Ser Leu Ser
   1               5                  10                  15    
 Ser Leu Gly Asp Ser Ala Pro Glu Arg Lys Ser Pro Ser His His Arg
              20                  25                  30        
 Gln Pro Ser Asp Ala Ser Glu Thr Thr Gly Leu Val Gln Arg Cys Val
          35                  40                  45            
 Ile Ile Gln Lys Asp Gln His Gly Phe Gly Phe Thr Val Ser Gly Asp
      50                  55                  60                
 Arg Ile Val Leu Val Gln Ser Val Arg Pro Gly Gly Ala Ala Met Lys
  65                  70                  75                  80
 Ala Gly Val Lys Glu Gly Asp Arg Ile Ile Lys Val Asn Gly Thr Met
                  85                  90                  95    
 Val Thr Asn Ser Ser His Leu Glu Val Val Lys Leu Ile Lys Ser Gly
             100                 105                 110        
 Ala Tyr Val Ala Leu Thr Leu Leu Gly Ser Ser Pro Ser Ser Met Gly
         115                 120                 125            
 Ile Ser Gly Leu Gln Gln Asp Pro Ser Pro Ala Gly Ala Pro Arg Ile
     130                 135                 140                
 Thr Ser Val Ile Pro Ser Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro
 145                 150                 155                 160
 Gln Arg Ile Thr Gly Pro Lys Pro Leu Gln Asp Pro Glu Val Gln Lys
                 165                 170                 175    
 His Ala Thr Gln Ile Leu Arg Asn Met Leu Arg Gln Glu Lys Lys Glu
             180                 185                 190        
 Leu Gln Arg Ile Cys Glu Val Tyr Ser Arg Asn Pro Ala Ser Leu Leu
         195                 200                 205            
 Glu Glu Gln Ile Glu Gly Ala Arg Arg Arg Val Thr Gln Leu Gln Leu
     210                 215                 220                
 Lys Ile Gln Gln Glu Thr Gly Gly Ser Val Asp Ile Leu Pro Leu Tyr
 225                 230                 235                 240
 Gly Asp Thr Ser Gln Arg Pro Ser Glu Gly Arg Leu Ser Leu Asp Ser
                 245                 250                 255    
 Gln Glu Gly Asp Ser Gly Leu Asp Ser Gly Thr Glu Arg Phe Pro Ser
             260                 265                 270        
 Leu Ser Glu Ser Leu Met Asn Arg Asn Ser Val Leu Ser Asp Pro Gly
         275                 280                 285            
 Leu Asp Ser Pro Arg Thr Ser Pro Val Ile Met Ala Arg Val Ala Gln
     290                 295                 300                
 His His Arg Arg Gln Gly Ser Asp Ala Ala Val Pro Ser Thr Gly Asp
 305                 310                 315                 320
 Gln Gly Val Asp Gln Ser Pro Lys Pro Leu Ile Ile Gly Pro Glu Glu
                 325                 330                 335    
 Asp Tyr Asp Pro Gly Tyr Phe Asn Asn Glu Ser Asp Ile Ile Phe Gln
             340                 345                 350        
 Asp Leu Glu Lys Leu Lys Ser Arg Pro Ala His Leu Gly Val Phe Leu
         355                 360                 365            
 Arg Tyr Ile Phe Ser Gln Ala Asp Pro Ser Pro Leu Leu Phe Tyr Leu
     370                 375                 380                
 Cys Ala Glu Val Tyr Gln Gln Ala Ser Pro Lys Asp Ser Arg Ser Leu
 385                 390                 395                 400
 Gly Lys Asp Ile Trp Asn Ile Phe Leu Glu Lys Asn Ala Pro Leu Arg
                 405                 410                 415    
 Val Lys Ile Pro Glu Met Leu Gln Ala Glu Ile Asp Ser Arg Leu Arg
             420                 425                 430        
 Asn Ser Glu Asp Ala Arg Gly Val Leu Cys Glu Ala Gln Glu Ala Ala
         435                 440                 445            
 Met Pro Glu Ile Gln Glu Gln Ile His Asp Tyr Arg Thr Lys Arg Thr
     450                 455                 460                
 Leu Gly Leu Gly Ser Leu Tyr Gly Glu Asn Asp Leu Leu Asp Leu Asp
 465                 470                 475                 480
 Gly Asp Pro Leu Arg Glu Arg Gln Val Ala Glu Lys Gln Leu Ala Ala
                 485                 490                 495    
 Leu Gly Asp Ile Leu Ser Lys Tyr Glu Glu Asp Arg Ser Ala Pro Met
             500                 505                 510        
 Asp Phe Ala Leu Asn Thr Tyr Met Ser His Ala Gly Ile Arg Leu Arg
         515                 520                 525            
 Glu Ala Arg Pro Ser Asn Thr Ala Glu Lys Ala Gln Ser Ala Pro Asp
     530                 535                 540                
 Lys Asp Lys Trp Leu Pro Phe Phe Pro Lys Thr Lys Lys Ser Ser Asn
 545                 550                 555                 560
 Ser Lys Lys Glu Lys Asp Ala Leu Glu Asp Lys Lys Arg Asn Pro Ile
                 565                 570                 575    
 Leu Lys Tyr Ile Gly Lys Pro Lys Ser Ser Ser Gln Ser Thr Phe His
             580                 585                 590        
 Ile Pro Leu Ser Pro Val Glu Val Lys Pro Gly Asn Val Arg Asn Ile
         595                 600                 605            
 Ile Gln His Phe Glu Asn Asn Gln Gln Tyr Asp Ala Pro Glu Pro Gly
     610                 615                 620                
 Thr Gln Arg Leu Ser Thr Gly Ser Phe Pro Glu Asp Leu Leu Glu Ser
 625                 630                 635                 640
 Asp Ser Ser Arg Ser Glu Ile Arg Leu Gly Arg Ser Glu Ser Leu Lys
                 645                 650                 655    
 Gly Arg Glu Glu Met Lys Arg Ser Arg Lys Ala Glu Asn Val Pro Arg
             660                 665                 670        
 Ser Arg Ser Asp Val Asp Met Asp Ala Ala Ala Glu Ala Thr Arg Leu
         675                 680                 685            
 His Gln Ser Ala Ser Ser Ser Thr Ser Ser Leu Ser Thr Arg Ser Leu
     690                 695                 700                
 Glu Asn Pro Thr Pro Pro Phe Thr Pro Lys Met Gly Arg Arg Ser Ile
 705                 710                 715                 720
 Glu Ser Pro Ser Leu Gly Phe Cys Thr Asp Thr Leu Leu Pro His Leu
                 725                 730                 735    
 Leu Glu Asp Asp Leu Gly Gln Leu Ser Asp Leu Glu Pro Glu Pro Asp
             740                 745                 750        
 Ala Gln Asn Trp Gln His Thr Val Gly Lys Asp Val Val Ala Gly Leu
         755                 760                 765            
 Thr Gln Arg Glu Ile Asp Arg Gln Glu Val Ile Asn Glu Leu Phe Val
     770                 775                 780                
 Thr Glu Ala Ser His Leu Arg Thr Leu Arg Val Leu Asp Leu Ile Phe
 785                 790                 795                 800
 Tyr Gln Arg Met Lys Lys Glu Asn Leu Met Pro Arg Glu Glu Leu Ala
                 805                 810                 815    
 Arg Leu Phe Pro Asn Leu Pro Glu Leu Ile Glu Ile His Asn Ser Trp
             820                 825                 830        
 Cys Glu Ala Met Lys Lys Leu Arg Glu Glu Gly Pro Ile Ile Lys Glu
         835                 840                 845            
 Ile Ser Asp Leu Met Leu Ala Arg Phe Asp Gly Pro Ala Arg Glu Glu
     850                 855                 860                
 Leu Gln Gln Val Ala Ala Gln Phe Cys Ser Tyr Gln Ser Ile Ala Leu
 865                 870                 875                 880
 Glu Leu Ile Lys Thr Lys Gln Arg Lys Glu Ser Arg Phe Gln Leu Phe
                 885                 890                 895    
 Met Gln Glu Ala Glu Ser His Pro Gln Cys Arg Arg Leu Gln Leu Arg
             900                 905                 910        
 Asp Leu Ile Ile Ser Glu Met Gln Arg Leu Thr Lys Tyr Pro Leu Leu
         915                 920                 925            
 Leu Glu Ser Ile Ile Lys His Thr Glu Gly Gly Thr Ser Glu His Glu
     930                 935                 940                
 Lys Leu Cys Arg Ala Arg Asp Gln Cys Arg Glu Ile Leu Lys Tyr Val
 945                 950                 955                 960
 Asn Glu Ala Val Lys Gln Thr Glu Asn Arg His Arg Leu Glu Gly Tyr
                 965                 970                 975    
 Gln Lys Arg Leu Asp Ala Thr Ala Leu Glu Arg Ala Ser Asn Pro Leu
             980                 985                 990        
 Ala Ala Glu Phe Lys Ser Leu Asp Leu Thr Thr Arg Lys Met Ile His
         995                1000                1005            
 Glu Gly Pro Leu Thr Trp Arg Ile Ser Lys Asp Lys Thr Leu Asp Leu
    1010                1015                1020                
 His Val Leu Leu Leu Glu Asp Leu Leu Val Leu Leu Gln Lys Gln Asp
1025                1030                1035                1040
 Glu Lys Leu Leu Leu Lys Cys His Ser Lys Thr Ala Val Gly Ser Ser
                1045                1050                1055    
 Asp Ser Lys Gln Thr Phe Ser Pro Val Leu Lys Leu Asn Ala Val Leu
            1060                1065                1070        
 Ile Arg Ser Val Ala Thr Asp Lys Arg Ala Phe Phe Ile Ile Cys Thr
        1075                1080                1085            
 Ser Lys Leu Gly Pro Pro Gln Ile Tyr Glu Leu Val Ala Leu Thr Ser
    1090                1095                1100                
 Ser Asp Lys Asn Thr Trp Met Glu Leu Leu Glu Glu Ala Val Arg Asn
1105                1110                1115                1120
 Ala Thr Arg His Pro Gly Ala Ala Pro Met Pro Val His Pro Pro Pro
                1125                1130                1135    
 Pro Gly Pro Arg Glu Pro Ala Gln Gln Gly Pro Thr Pro Ser Arg Val
            1140                1145                1150        
 Glu Leu Asp Asp Ser Asp Val Phe His Gly Glu Pro Glu Pro Glu Glu
        1155                1160                1165            
 Leu Pro Gly Gly Thr Gly Ser Gln Gln Arg Val Gln Gly Lys His Gln
    1170                1175                1180                
 Val Leu Leu Glu Asp Pro Glu Gln Glu Gly Ser Ala Glu Glu Glu Glu
1185                1190                1195                1200
 Leu Gly Val Leu Pro Cys Pro Ser Thr Ser Leu Asp Gly Glu Asn Arg
                1205                1210                1215    
 Gly Ile Arg Thr Arg Asn Pro Ile His Leu Ala Phe Pro Gly Pro Leu
            1220                1225                1230        
 Phe Met Glu Gly Leu Ala Asp Ser Ala Leu Glu Asp Val Glu Asn Leu
        1235                1240                1245            
 Arg His Leu Ile Leu Trp Ser Leu Leu Pro Gly His Thr Met Glu Thr
    1250                1255                1260                
 Gln Ala Ala Gln Glu Pro Glu Asp Asp Leu Thr Pro Thr Pro Ser Val
1265                1270                1275                1280
 Ile Ser Val Thr Ser His Pro Trp Asp Pro Gly Ser Pro Gly Gln Ala
                1285                1290                1295    
 Pro Pro Gly Gly Glu Gly Asp Asn Thr Gln Leu Ala Gly Leu Glu Gly
            1300                1305                1310        
 Glu Arg Pro Glu Gln Glu Asp Met Gly Leu Cys Ser Leu Glu His Leu
        1315                1320                1325            
 Pro Pro Arg Thr Arg Asn Ser Gly Ile Trp Glu Ser Pro Glu Leu Asp
    1330                1335                1340                
 Arg Asn Leu Ala Glu Asp Ala Ser Ser Thr Glu Ala Ala Gly Gly Tyr
1345                1350                1355                1360
 Lys Val Val Arg Lys Ala Glu Val Ala Gly Ser Lys Val Val Pro Ala
                1365                1370                1375    
 Leu Pro Glu Ser Gly Gln Ser Glu Pro Gly Pro Pro Glu Val Glu Gly
            1380                1385                1390        
 Gly Thr Lys Ala Thr Gly Asn Cys Phe Tyr Val Ser Met Pro Ser Gly
        1395                1400                1405            
 Pro Pro Asp Ser Ser Thr Asp His Ser Glu Ala Pro Met Ser Pro Pro
    1410                1415                1420                
 Gln Pro Asp Ser Leu Pro Ala Gly Gln Thr Glu Pro Gln Pro Gln Leu
1425                1430                1435                1440
 Gln Gly Gly Asn Asp Asp Pro Arg Arg Pro Ser Arg Ser Pro Pro Gly
                1445                1450                1455    
 Leu Ala Leu Arg Asp Val Gly Met Ile Phe His Thr Ile Glu Gln Leu
            1460                1465                1470        
 Thr Leu Lys Leu Asn Arg Leu Lys Asp Met Glu Leu Ala His Arg Glu
        1475                1480                1485            
 Leu Leu Lys Ser Leu Gly Gly Glu Ser Ser Gly Gly Thr Thr Pro Val
    1490                1495                1500                
 Gly Ser Phe His Thr Glu Ala Ala Arg Trp Thr Asp Gly Ser Leu Ser
1505                1510                1515                1520
 Pro Pro Ala Lys Glu Pro Leu Ala Ser Asp Ser Arg Asn Ser His Glu
                1525                1530                1535    
 Leu Gly Pro Cys Pro Glu Asp Gly Ser Asp Ala Pro Leu Glu Asp Ser
            1540                1545                1550        
 Thr Ala Asp Ala Ala Ala Ser Pro Gly Pro
        1555                1560        



      <210> 1036
      <211> 485
      <212> PRT
      <213> Homo sapiens


      <400> 1036
 Met Arg Pro Lys Pro His Tyr Val Val Ile Lys Lys Asp Ala Glu Thr
   1               5                  10                  15    
 Asn Glu Ala Ile Tyr Cys Thr Lys Glu Pro Phe Ile Lys Ala Arg Val
              20                  25                  30        
 Ile Val Ile Arg Trp Leu Val Ser Phe Trp Leu Glu Pro Lys Pro His
          35                  40                  45            
 Thr Gly Pro His Ile Pro Gly Met Glu Gly Glu Val Leu Pro Lys Asn
      50                  55                  60                
 Ile Gln Arg Ala Ala Ala Ser Leu Val Ser Arg Glu Glu Ser Lys Asn
  65                  70                  75                  80
 Asp Asn Ala Asp Lys Thr Asp Arg Thr Thr Glu Pro Glu Gln Ser His
                  85                  90                  95    
 Ser Asn Thr Ser Thr Leu Thr Glu Arg Glu Pro Ser Ser Ser Ser Leu
             100                 105                 110        
 Cys Ser Ile Asp Glu Glu His Leu Thr Asp Ile Glu Ile Val Arg Arg
         115                 120                 125            
 Val Phe Ser Ser Lys Arg Ser Asn Val Asn Phe Val Thr Glu Ile Phe
     130                 135                 140                
 Arg Gln Ala Phe Leu Leu Pro Ile Cys Glu Ala Ala Ala Met Arg Lys
 145                 150                 155                 160
 Val Val Lys Val Tyr Gln Glu Trp Ile Gln Gln Glu Glu Lys Pro Leu
                 165                 170                 175    
 Phe Met Gln Glu Pro Glu Glu Ile Val Ile Thr Ser Ser Asp Leu Pro
             180                 185                 190        
 Cys Ile Glu Asn Val Thr Asp His Asp Ile Ser Met Glu Glu Gly Glu
         195                 200                 205            
 Lys Arg Glu Glu Glu Asn Gly Thr Asn Thr Ala Asp His Val Arg Asn
     210                 215                 220                
 Ser Ser Trp Ala Lys Asn Gly Ser Tyr Gln Gly Ala Leu His Asn Ala
 225                 230                 235                 240
 Ser Glu Glu Ala Thr Glu Gln Asn Ile Arg Ala Gly Thr Gln Ala Val
                 245                 250                 255    
 Leu Gln Val Phe Ile Ile Asn Ser Ser Asn Ile Phe Leu Leu Glu Pro
             260                 265                 270        
 Ala Asn Glu Ile Lys Asn Leu Leu Asp Glu His Thr Asp Met Cys Lys
         275                 280                 285            
 Arg Ile Leu Asn Ile Tyr Arg Tyr Met Val Val Gln Val Ser Met Asp
     290                 295                 300                
 Lys Lys Thr Trp Glu Gln Met Leu Leu Val Leu Leu Arg Val Thr Glu
 305                 310                 315                 320
 Ser Val Leu Lys Met Pro Ser Gln Ala Phe Leu Gln Phe Gln Gly Lys
                 325                 330                 335    
 Lys Asn Met Thr Leu Ala Gly Arg Leu Ala Gly Pro Leu Phe Gln Thr
             340                 345                 350        
 Leu Ile Val Ala Trp Ile Lys Ala Asn Leu Asn Val Tyr Ile Ser Arg
         355                 360                 365            
 Glu Leu Trp Asp Asp Leu Leu Ser Val Leu Ser Ser Leu Thr Tyr Trp
     370                 375                 380                
 Glu Glu Leu Ala Thr Glu Trp Ser Leu Thr Met Glu Thr Leu Thr Lys
 385                 390                 395                 400
 Val Leu Ala Arg Asn Leu Tyr Ser Leu Asp Leu Ser Asp Leu Pro Leu
                 405                 410                 415    
 Asp Lys Leu Ser Glu Gln Lys Gln Lys Lys His Lys Gly Lys Gly Val
             420                 425                 430        
 Gly His Glu Phe Gln Lys Val Ser Val Asp Lys Ser Phe Ser Arg Gly
         435                 440                 445            
 Trp Ser Arg Asp Gln Pro Gly Gln Ala Pro Met Arg Gln Arg Ser Ala
     450                 455                 460                
 Thr Thr Thr Gly Ser Pro Gly Thr Glu Lys Ala Arg Ser Ile Val Arg
 465                 470                 475                 480
 Gln Lys Thr Val Gly
                 485



      <210> 1037
      <211> 340
      <212> PRT
      <213> Homo sapiens


      <400> 1037
 Met Ala Ser Leu Leu Gln Asp Gln Leu Thr Thr Asp Gln Asp Leu Leu
   1               5                  10                  15    
 Leu Met Gln Glu Gly Met Pro Met Arg Lys Val Arg Ser Lys Ser Trp
              20                  25                  30        
 Lys Lys Leu Arg Tyr Phe Arg Leu Gln Asn Asp Gly Met Thr Val Trp
          35                  40                  45            
 His Ala Arg Gln Ala Arg Gly Ser Ala Lys Pro Ser Phe Ser Ile Ser
      50                  55                  60                
 Asp Val Glu Thr Ile Arg Asn Gly His Asp Ser Glu Leu Leu Arg Ser
  65                  70                  75                  80
 Leu Ala Glu Glu Leu Pro Leu Glu Gln Gly Phe Thr Ile Val Phe His
                  85                  90                  95    
 Gly Arg Arg Ser Asn Leu Asp Leu Met Ala Asn Ser Val Glu Glu Ala
             100                 105                 110        
 Gln Ile Trp Met Arg Gly Leu Gln Leu Leu Val Asp Leu Val Thr Ser
         115                 120                 125            
 Met Asp His Gln Glu Arg Leu Asp Gln Trp Leu Ser Asp Trp Phe Gln
     130                 135                 140                
 Arg Gly Asp Lys Asn Gln Asp Gly Lys Met Ser Phe Gln Glu Val Gln
 145                 150                 155                 160
 Arg Leu Leu His Leu Met Asn Val Glu Met Asp Gln Glu Tyr Ala Phe
                 165                 170                 175    
 Ser Leu Phe Gln Ala Ala Asp Thr Ser Gln Ser Gly Thr Leu Glu Gly
             180                 185                 190        
 Glu Glu Phe Val Gln Phe Tyr Lys Ala Leu Thr Lys Arg Ala Glu Val
         195                 200                 205            
 Gln Glu Leu Phe Glu Ser Phe Ser Ala Asp Gly Gln Lys Leu Thr Leu
     210                 215                 220                
 Leu Glu Phe Leu Asp Phe Leu Gln Glu Glu Gln Lys Glu Arg Asp Cys
 225                 230                 235                 240
 Thr Ser Glu Leu Ala Leu Glu Leu Ile Asp Arg Tyr Glu Pro Ser Asp
                 245                 250                 255    
 Ser Gly Lys Leu Arg His Val Leu Ser Met Asp Gly Phe Leu Ser Tyr
             260                 265                 270        
 Leu Cys Ser Lys Asp Gly Asp Ile Phe Asn Pro Ala Cys Leu Pro Ile
         275                 280                 285            
 Tyr Gln Asp Met Thr Gln Pro Leu Asn His Tyr Phe Ile Cys Ser Ser
     290                 295                 300                
 His Asn Thr Tyr Leu Val Gly Asp Gln Leu Cys Gly Gln Ser Ser Val
 305                 310                 315                 320
 Glu Gly Tyr Ile Arg Cys Ser Gly Gly Arg Glu Gly Val Gln Leu Met
                 325                 330                 335    
 Arg Gly Thr Met
             340



      <210> 1038
      <211> 395
      <212> PRT
      <213> Homo sapiens


      <400> 1038
 Met Asp Leu Cys Gln Lys Asn Glu Thr Asp Leu Glu Asn Ala Glu Asn
   1               5                  10                  15    
 Asn Glu Ile Gln Phe Thr Glu Glu Thr Glu Pro Thr Tyr Thr Cys Pro
              20                  25                  30        
 Asp Gly Lys Ser Glu Lys Asn His Val Tyr Cys Leu Leu Asp Val Ser
          35                  40                  45            
 Asp Ile Thr Leu Glu Gln Asp Glu Lys Ala Lys Glu Phe Ile Ile Gly
      50                  55                  60                
 Thr Gly Trp Glu Glu Ala Val Gln Gly Trp Gly Arg Thr Ser Pro Ala
  65                  70                  75                  80
 Ala Cys Ile Trp Pro Arg Lys Ile Pro Lys Lys Ala Arg Val Gly Glu
                  85                  90                  95    
 Gly Ala Cys Ser Asp Cys Leu Val Cys Val Asn Leu Ser His Trp Ser
             100                 105                 110        
 Leu Gln Thr Lys Pro Pro Thr Glu Gly Gly Pro Glu Lys Asp Gln Ser
         115                 120                 125            
 Ser Pro Ser Gln Thr Gln Ala Ala Pro Gln Gly Pro Ser Thr Ala Ser
     130                 135                 140                
 Arg Ala Ile Ser Asp Ile Cys Phe Pro Thr Tyr Phe Arg Ala Glu Lys
 145                 150                 155                 160
 Lys Ser Leu Gln Ile Lys Glu Phe Ile Trp Cys Asn Lys Asp Trp Ala
                 165                 170                 175    
 Ile Pro Gly Thr Asn Arg Gly Lys Ala Ser Gly Asn Pro Ser Gly Gly
             180                 185                 190        
 Ala His Arg Gly Leu Ser Ile Pro Gly Pro Leu Thr Ser Arg Ala Leu
         195                 200                 205            
 Leu Val Leu Pro Pro Leu Lys Ala Ser Leu Ser Asn Ala Leu Asp Val
     210                 215                 220                
 Leu Gly Lys Lys Ser Lys Asn Ser Phe Leu Gln Ser Glu Glu Lys Val
 225                 230                 235                 240
 Leu Asp Val Glu Lys Asp Gly Cys Val Ala Tyr Ala Tyr Gly Leu Lys
                 245                 250                 255    
 Thr Ala Asp Gly Lys Gly Glu Lys Arg Ala Ser Glu Leu Ala Lys His
             260                 265                 270        
 Pro Met Val Asn Asp Thr Pro Ser Ser Pro Ser Pro Ala Ala Gln Ile
         275                 280                 285            
 Ser Leu Leu Thr Asp Pro Glu Gln Arg Cys Leu His Trp Ser Leu Leu
     290                 295                 300                
 Ser Glu Lys Asn Leu Ala Cys Pro Pro Asp Pro Ser Asn Val Arg Tyr
 305                 310                 315                 320
 Leu Ala Ala Leu Gln Leu Leu Gln Lys Arg Gly Val Gln Ser Tyr Lys
                 325                 330                 335    
 Ser Lys Phe Lys Ala Lys Glu Pro Arg Ser Pro Val Ile Thr Arg Lys
             340                 345                 350        
 His Val Leu Pro Lys Ala Lys Gln Glu Asn Arg Pro Gln Met Leu Glu
         355                 360                 365            
 Thr Lys Val Phe Pro Arg Pro Val Leu Pro Ser Leu Thr Val Ser Arg
     370                 375                 380                
 Val Ile Ile Pro Val Ser Thr His Arg Ile Leu
 385                 390                 395



      <210> 1039
      <211> 310
      <212> PRT
      <213> Homo sapiens


      <400> 1039
 Met Gly Asp Asn Ile Thr Ser Ile Thr Glu Phe Leu Leu Leu Gly Phe
   1               5                  10                  15    
 Pro Val Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu
              20                  25                  30        
 Phe Tyr Val Phe Thr Leu Leu Gly Asn Gly Thr Ile Leu Gly Leu Ile
          35                  40                  45            
 Ser Leu Asp Ser Arg Leu His Ala Pro Met Tyr Phe Phe Leu Ser His
      50                  55                  60                
 Leu Ala Val Val Asp Ile Ala Tyr Ala Cys Asn Thr Val Pro Arg Met
  65                  70                  75                  80
 Leu Val Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly Arg
                  85                  90                  95    
 Met Met Gln Thr Phe Leu Phe Ser Thr Phe Ala Val Thr Glu Cys Leu
             100                 105                 110        
 Leu Leu Val Val Met Ser Tyr Asp Leu Tyr Val Ala Ile Cys His Pro
         115                 120                 125            
 Leu Arg Tyr Leu Ala Ile Met Thr Trp Arg Val Cys Ile Thr Leu Ala
     130                 135                 140                
 Val Thr Ser Trp Thr Thr Gly Val Leu Leu Ser Leu Ile His Leu Val
 145                 150                 155                 160
 Leu Leu Leu Pro Leu Pro Phe Cys Arg Pro Gln Lys Ile Tyr His Phe
                 165                 170                 175    
 Phe Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Thr His
             180                 185                 190        
 Ile Asn Glu Asn Met Val Leu Ala Gly Ala Ile Ser Gly Leu Val Gly
         195                 200                 205            
 Pro Leu Ser Thr Ile Val Val Ser Tyr Met Cys Ile Leu Cys Ala Ile
     210                 215                 220                
 Leu Gln Ile Gln Ser Arg Glu Val Gln Arg Lys Ala Phe Arg Thr Cys
 225                 230                 235                 240
 Phe Ser His Leu Cys Val Ile Gly Leu Val Tyr Gly Thr Ala Ile Ile
                 245                 250                 255    
 Met Tyr Val Gly Pro Arg Tyr Gly Asn Pro Lys Glu Gln Lys Lys Tyr
             260                 265                 270        
 Leu Leu Leu Phe His Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile
         275                 280                 285            
 Cys Ser Leu Arg Asn Ser Glu Val Lys Asn Thr Leu Lys Arg Val Leu
     290                 295                 300                
 Gly Val Glu Arg Ala Leu
 305                 310



      <210> 1040
      <211> 870
      <212> PRT
      <213> Homo sapiens


      <400> 1040
 Met Gly Arg Leu Asn Lys Ala Ile Leu Arg Tyr Leu Lys Asn Asp Gly
   1               5                  10                  15    
 Lys Val His Leu Val Val Phe Asn Asn Leu Gln Leu Ala Asp Gly Arg
              20                  25                  30        
 Arg His Arg Ile Leu Leu Arg Leu Ser Asn Leu Gln Arg Gly Ala Gly
          35                  40                  45            
 Ser Leu Glu Leu Tyr Leu Asp Cys Ile Gln Val Asp Ser Val His Asn
      50                  55                  60                
 Leu Pro Arg Ala Phe Ala Gly Pro Ser Gln Lys Pro Glu Thr Ile Glu
  65                  70                  75                  80
 Leu Arg Thr Phe Gln Arg Lys Pro Gln Asp Phe Leu Glu Glu Leu Lys
                  85                  90                  95    
 Leu Val Val Arg Gly Ser Leu Phe Gln Val Ala Ser Leu Gln Asp Cys
             100                 105                 110        
 Phe Leu Gln Gln Ser Glu Pro Leu Ala Ala Thr Gly Thr Gly Asp Phe
         115                 120                 125            
 Asn Arg Gln Phe Leu Gly Gln Met Thr Gln Leu Asn Gln Leu Leu Gly
     130                 135                 140                
 Glu Val Lys Asp Leu Leu Arg Gln Gln Val Lys Glu Thr Ser Phe Leu
 145                 150                 155                 160
 Arg Asn Thr Ile Ala Glu Cys Gln Ala Cys Gly Pro Leu Lys Phe Gln
                 165                 170                 175    
 Ser Pro Thr Pro Ser Thr Val Val Ala Pro Ala Pro Pro Ala Pro Pro
             180                 185                 190        
 Thr Arg Pro Pro Arg Arg Cys Asp Ser Asn Pro Cys Phe Arg Gly Val
         195                 200                 205            
 Gln Cys Thr Asp Ser Arg Asp Gly Phe Gln Cys Gly Pro Cys Pro Glu
     210                 215                 220                
 Gly Tyr Thr Gly Asn Gly Ile Thr Cys Ile Asp Val Asp Glu Cys Lys
 225                 230                 235                 240
 Tyr His Pro Cys Tyr Pro Gly Val His Cys Ile Asn Leu Ser Pro Gly
                 245                 250                 255    
 Phe Arg Cys Asp Ala Cys Pro Val Gly Phe Thr Gly Pro Met Val Gln
             260                 265                 270        
 Gly Val Gly Ile Ser Phe Ala Lys Ser Asn Lys Gln Val Cys Thr Asp
         275                 280                 285            
 Ile Asp Glu Cys Arg Asn Gly Ala Cys Val Pro Asn Ser Ile Cys Val
     290                 295                 300                
 Asn Thr Leu Gly Ser Tyr Arg Cys Gly Pro Cys Lys Pro Gly Tyr Thr
 305                 310                 315                 320
 Gly Asp Gln Ile Arg Gly Cys Lys Ala Glu Arg Asn Cys Arg Asn Pro
                 325                 330                 335    
 Glu Leu Asn Pro Cys Ser Val Asn Ala Gln Cys Ile Glu Glu Arg Gln
             340                 345                 350        
 Gly Asp Val Thr Cys Val Cys Gly Val Gly Trp Ala Gly Asp Gly Tyr
         355                 360                 365            
 Ile Cys Gly Lys Asp Val Asp Ile Asp Ser Tyr Pro Asp Glu Glu Leu
     370                 375                 380                
 Pro Cys Ser Ala Arg Asn Cys Lys Lys Asp Asn Cys Lys Tyr Val Pro
 385                 390                 395                 400
 Asn Ser Gly Gln Glu Asp Ala Asp Arg Asp Gly Ile Gly Asp Ala Cys
                 405                 410                 415    
 Asp Glu Asp Ala Asp Gly Asp Gly Ile Leu Asn Glu Gln Asp Asn Cys
             420                 425                 430        
 Val Leu Ile His Asn Val Asp Gln Arg Asn Ser Asp Lys Asp Ile Phe
         435                 440                 445            
 Gly Asp Ala Cys Asp Asn Cys Leu Ser Val Leu Asn Asn Asp Gln Lys
     450                 455                 460                
 Asp Thr Asp Gly Asp Gly Arg Gly Asp Ala Cys Asp Asp Asp Met Asp
 465                 470                 475                 480
 Gly Asp Gly Ile Lys Asn Ile Leu Asp Asn Cys Pro Lys Phe Pro Asn
                 485                 490                 495    
 Arg Asp Gln Arg Asp Lys Asp Gly Asp Gly Val Gly Asp Ala Cys Asp
             500                 505                 510        
 Ser Cys Pro Asp Val Ser Asn Pro Asn Gln Ser Asp Val Asp Asn Asp
         515                 520                 525            
 Leu Val Gly Asp Ser Cys Asp Thr Asn Gln Asp Ser Asp Gly Asp Gly
     530                 535                 540                
 His Gln Asp Ser Thr Asp Asn Cys Pro Thr Val Ile Asn Ser Ala Gln
 545                 550                 555                 560
 Leu Asp Thr Asp Lys Asp Gly Ile Gly Asp Glu Cys Asp Asp Asp Asp
                 565                 570                 575    
 Asp Asn Asp Gly Ile Pro Asp Leu Val Pro Pro Gly Pro Asp Asn Cys
             580                 585                 590        
 Arg Leu Val Pro Asn Pro Ala Gln Glu Asp Ser Asn Ser Asp Gly Val
         595                 600                 605            
 Gly Asp Ile Cys Glu Ser Asp Phe Asp Gln Asp Gln Val Ile Asp Arg
     610                 615                 620                
 Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu Thr Asp Phe Arg
 625                 630                 635                 640
 Ala Tyr Gln Thr Val Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp
                 645                 650                 655    
 Pro Asn Trp Val Val Leu Asn Gln Gly Met Glu Ile Val Gln Thr Met
             660                 665                 670        
 Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val
         675                 680                 685            
 Asp Phe Glu Gly Thr Phe His Val Asn Thr Gln Thr Asp Asp Asp Tyr
     690                 695                 700                
 Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val
 705                 710                 715                 720
 Met Trp Lys Gln Thr Glu Gln Thr Tyr Trp Gln Ala Thr Pro Phe Arg
                 725                 730                 735    
 Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys Ser Lys Thr
             740                 745                 750        
 Gly Pro Gly Glu His Leu Arg Asn Ser Leu Trp His Thr Gly Asp Thr
         755                 760                 765            
 Ser Asp Gln Val Arg Leu Leu Trp Lys Asp Ser Arg Asn Val Gly Trp
     770                 775                 780                
 Lys Asp Lys Val Ser Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val
 785                 790                 795                 800
 Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Ser Glu Leu Val Ala Asp
                 805                 810                 815    
 Ser Gly Val Thr Ile Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val
             820                 825                 830        
 Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ser Asn Leu Lys Tyr Arg
         835                 840                 845            
 Cys Asn Asp Thr Ile Pro Glu Asp Phe Gln Glu Phe Gln Thr Gln Asn
     850                 855                 860                
 Phe Asp Arg Phe Asp Asn
 865                 870



      <210> 1041
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 1041
 Met Ser Pro Gly Cys Met Leu Leu Phe Val Phe Gly Phe Val Gly Gly
   1               5                  10                  15    
 Ala Val Val Ile Asn Ser Ala Ile Leu Val Ser Leu Ser Val Leu Leu
              20                  25                  30        
 Leu Val His Phe Ser Ile Ser Thr Gly Val Pro Ala Leu Thr Gln Asn
          35                  40                  45            
 Leu Pro Arg Ile Leu Arg Lys Glu Arg Pro Ile Ser Leu Gly Ile Phe
      50                  55                  60                
 Pro Leu Pro Ala Gly Asp Gly Leu Leu Thr Pro Asp Ala Gln Lys Gly
  65                  70                  75                  80
 Gly Glu Thr Pro Gly Ser Glu Gln Trp Lys Phe Gln Glu Leu Ser Gln
                  85                  90                  95    
 Pro Arg Ser His Thr Ser Leu Lys Val Ser Asn Ser Pro Glu Pro Gln
             100                 105                 110        
 Lys Ala Val Glu Gln Glu Val Arg Met Val Leu Leu Asn Ile Leu Gln
         115                 120                 125            
 Lys Val Tyr
     130    



      <210> 1042
      <211> 553
      <212> PRT
      <213> Homo sapiens


      <400> 1042
 Met Glu Gly Ser Gly Gly Gly Ala Gly Glu Arg Ala Pro Leu Leu Gly
   1               5                  10                  15    
 Ala Arg Arg Ala Ala Ala Ala Ala Ala Ala Ala Gly Ala Phe Ala Gly
              20                  25                  30        
 Arg Arg Ala Ala Cys Gly Ala Val Leu Leu Thr Glu Leu Leu Glu Arg
          35                  40                  45            
 Ala Ala Phe Tyr Gly Ile Thr Ser Asn Leu Val Leu Phe Leu Asn Gly
      50                  55                  60                
 Ala Pro Phe Cys Trp Glu Gly Ala Gln Ala Ser Glu Ala Leu Leu Leu
  65                  70                  75                  80
 Phe Met Gly Leu Thr Tyr Leu Gly Ser Pro Phe Gly Gly Trp Leu Ala
                  85                  90                  95    
 Asp Ala Arg Leu Gly Arg Ala Arg Ala Ile Leu Leu Ser Leu Ala Leu
             100                 105                 110        
 Tyr Leu Leu Gly Met Leu Ala Phe Pro Leu Leu Ala Ala Pro Ala Thr
         115                 120                 125            
 Arg Ala Ala Leu Cys Gly Ser Ala Arg Leu Leu Asn Cys Thr Ala Pro
     130                 135                 140                
 Gly Pro Asp Ala Ala Ala Arg Cys Cys Ser Pro Ala Thr Phe Ala Gly
 145                 150                 155                 160
 Leu Val Leu Val Gly Leu Gly Val Ala Thr Val Lys Ala Asn Ile Thr
                 165                 170                 175    
 Pro Phe Gly Ala Asp Gln Val Lys Asp Arg Gly Pro Glu Ala Thr Arg
             180                 185                 190        
 Arg Phe Phe Asn Trp Phe Tyr Trp Ser Ile Asn Leu Gly Ala Ile Leu
         195                 200                 205            
 Ser Leu Gly Gly Ile Ala Tyr Ile Gln Gln Asn Val Ser Phe Val Thr
     210                 215                 220                
 Gly Tyr Ala Ile Pro Thr Val Cys Val Gly Leu Ala Phe Val Val Phe
 225                 230                 235                 240
 Leu Cys Gly Gln Ser Val Phe Ile Thr Lys Pro Pro Asp Gly Ser Ala
                 245                 250                 255    
 Phe Thr Asp Met Phe Lys Ile Leu Thr Tyr Ser Cys Cys Ser Gln Lys
             260                 265                 270        
 Arg Ser Gly Glu Arg Gln Ser Asn Gly Glu Gly Ile Gly Val Phe Gln
         275                 280                 285            
 Gln Ser Ser Lys Gln Ser Leu Phe Asp Ser Cys Lys Met Ser His Gly
     290                 295                 300                
 Gly Pro Phe Thr Glu Glu Lys Val Glu Asp Val Lys Ala Leu Val Lys
 305                 310                 315                 320
 Ile Val Pro Val Phe Leu Ala Leu Ile Pro Tyr Trp Thr Val Tyr Phe
                 325                 330                 335    
 Gln Leu Pro Ala Ala Trp Leu Thr Met Phe Asp Ala Val Leu Ile Leu
             340                 345                 350        
 Leu Leu Ile Pro Leu Lys Asp Lys Leu Val Asp Pro Ile Leu Arg Arg
         355                 360                 365            
 His Gly Leu Leu Pro Ser Ser Leu Lys Arg Ile Ala Val Gly Met Phe
     370                 375                 380                
 Phe Val Met Cys Ser Ala Phe Ala Ala Glu Gly Ile Leu Glu Ser Lys
 385                 390                 395                 400
 Arg Leu Asn Leu Val Lys Glu Lys Thr Ile Asn Gln Thr Ile Gly Asn
                 405                 410                 415    
 Val Val Tyr His Ala Ala Asp Leu Ser Leu Trp Trp Gln Val Pro Gln
             420                 425                 430        
 Tyr Leu Leu Ile Gly Ile Ser Glu Ile Phe Ala Ser Ile Ala Gly Leu
         435                 440                 445            
 Glu Phe Ala Tyr Ser Ala Ala Pro Lys Ser Met Gln Ser Ala Ile Met
     450                 455                 460                
 Gly Leu Phe Phe Phe Phe Ser Gly Val Gly Ser Phe Val Gly Ser Gly
 465                 470                 475                 480
 Leu Leu Ala Leu Val Ser Ile Lys Ala Ile Gly Trp Met Ser Ser His
                 485                 490                 495    
 Thr Asp Phe Gly Gly Asn Ile Asn Gly Cys Tyr Leu Asn Tyr Tyr Phe
             500                 505                 510        
 Phe Leu Leu Ala Ala Ile Gln Gly Ala Thr Leu Leu Leu Phe Leu Ile
         515                 520                 525            
 Ile Ser Val Lys Tyr Asp His His Arg Asp His Gln Arg Ser Arg Ala
     530                 535                 540                
 Asn Gly Val Pro Thr Ser Arg Arg Ala
 545                 550            



      <210> 1043
      <211> 1068
      <212> PRT
      <213> Homo sapiens


      <400> 1043
 Met Ala Pro Arg Lys Arg Ser His His Gly Leu Gly Phe Leu Cys Cys
   1               5                  10                  15    
 Phe Gly Gly Ser Asp Ile Pro Glu Ile Asn Leu Arg Asp Asn His Pro
              20                  25                  30        
 Leu Gln Phe Met Glu Phe Ser Ser Pro Ile Pro Asn Ala Glu Glu Leu
          35                  40                  45            
 Asn Ile Arg Phe Ala Glu Leu Val Asp Glu Leu Asp Leu Thr Asp Lys
      50                  55                  60                
 Asn Arg Glu Ala Met Phe Ala Leu Pro Pro Glu Lys Lys Trp Gln Ile
  65                  70                  75                  80
 Tyr Cys Ser Lys Lys Lys Glu Gln Glu Asp Pro Asn Lys Leu Ala Thr
                  85                  90                  95    
 Ser Trp Pro Asp Tyr Tyr Ile Asp Arg Ile Asn Ser Met Ala Ala Met
             100                 105                 110        
 Gln Ser Leu Tyr Ala Phe Asp Glu Glu Glu Thr Glu Met Arg Asn Gln
         115                 120                 125            
 Val Val Glu Asp Leu Lys Thr Ala Leu Arg Thr Gln Pro Met Arg Phe
     130                 135                 140                
 Val Thr Arg Phe Ile Glu Leu Glu Gly Leu Thr Cys Leu Leu Asn Phe
 145                 150                 155                 160
 Leu Arg Ser Met Asp His Ala Thr Cys Glu Ser Arg Ile His Thr Ser
                 165                 170                 175    
 Leu Ile Gly Cys Ile Lys Ala Leu Met Asn Asn Ser Gln Gly Arg Ala
             180                 185                 190        
 His Val Leu Ala Gln Pro Glu Ala Ile Ser Thr Ile Ala Gln Ser Leu
         195                 200                 205            
 Arg Thr Glu Asn Ser Lys Thr Lys Val Ala Val Leu Glu Ile Leu Gly
     210                 215                 220                
 Ala Val Cys Leu Val Pro Gly Gly His Lys Lys Val Leu Gln Ala Met
 225                 230                 235                 240
 Leu His Tyr Gln Val Tyr Ala Ala Glu Arg Thr Arg Phe Gln Thr Leu
                 245                 250                 255    
 Leu Asn Glu Leu Asp Arg Ser Leu Gly Arg Tyr Arg Asp Glu Val Asn
             260                 265                 270        
 Leu Lys Thr Ala Ile Met Ser Phe Ile Asn Ala Val Leu Asn Ala Gly
         275                 280                 285            
 Ala Gly Glu Asp Asn Leu Glu Phe Arg Leu His Leu Arg Tyr Glu Phe
     290                 295                 300                
 Leu Met Leu Gly Ile Gln Pro Val Ile Asp Lys Leu Arg Gln His Glu
 305                 310                 315                 320
 Asn Ala Ile Leu Asp Lys His Leu Asp Phe Phe Glu Met Val Arg Asn
                 325                 330                 335    
 Glu Asp Asp Leu Glu Leu Ala Arg Arg Phe Asp Met Val His Ile Asp
             340                 345                 350        
 Thr Lys Ser Ala Ser Gln Met Phe Glu Leu Ile His Lys Lys Leu Lys
         355                 360                 365            
 Tyr Thr Glu Ala Tyr Pro Cys Leu Leu Ser Val Leu His His Cys Leu
     370                 375                 380                
 Gln Met Pro Tyr Lys Arg Asn Gly Gly Tyr Phe Gln Gln Trp Gln Leu
 385                 390                 395                 400
 Leu Asp Arg Ile Leu Gln Gln Ile Val Leu Gln Asp Glu Arg Gly Val
                 405                 410                 415    
 Asp Pro Asp Leu Ala Pro Leu Glu Asn Phe Asn Val Lys Asn Ile Val
             420                 425                 430        
 Asn Met Leu Ile Asn Glu Asn Glu Val Lys Gln Trp Arg Asp Gln Ala
         435                 440                 445            
 Glu Lys Phe Arg Lys Glu His Met Glu Leu Val Ser Arg Leu Glu Arg
     450                 455                 460                
 Lys Glu Arg Glu Cys Glu Thr Lys Thr Leu Glu Lys Glu Glu Met Met
 465                 470                 475                 480
 Arg Thr Leu Asn Lys Met Lys Asp Lys Leu Ala Arg Glu Ser Gln Glu
                 485                 490                 495    
 Leu Arg Gln Ala Arg Gly Gln Val Ala Glu Leu Val Ala Gln Leu Ser
             500                 505                 510        
 Glu Leu Ser Thr Gly Pro Val Ser Ser Pro Pro Pro Pro Gly Gly Pro
         515                 520                 525            
 Leu Thr Leu Ser Ser Ser Met Thr Thr Asn Asp Leu Pro Pro Pro Pro
     530                 535                 540                
 Pro Pro Leu Pro Phe Ala Cys Cys Pro Pro Pro Pro Pro Pro Pro Leu
 545                 550                 555                 560
 Pro Pro Gly Gly Pro Pro Thr Pro Pro Gly Ala Pro Pro Cys Leu Gly
                 565                 570                 575    
 Met Gly Leu Pro Leu Pro Gln Asp Pro Tyr Pro Ser Ser Asp Val Pro
             580                 585                 590        
 Leu Arg Lys Lys Arg Val Pro Gln Pro Ser His Pro Leu Lys Ser Phe
         595                 600                 605            
 Asn Trp Val Lys Leu Asn Glu Glu Arg Val Pro Gly Thr Val Trp Asn
     610                 615                 620                
 Glu Ile Asp Asp Met Gln Val Phe Arg Ile Leu Asp Leu Glu Asp Phe
 625                 630                 635                 640
 Glu Lys Met Phe Ser Ala Tyr Gln Arg His Gln Lys Glu Leu Gly Ser
                 645                 650                 655    
 Thr Glu Asp Ile Tyr Leu Ala Ser Arg Lys Val Lys Glu Leu Ser Val
             660                 665                 670        
 Ile Asp Gly Arg Arg Ala Gln Asn Cys Ile Ile Leu Leu Ser Lys Leu
         675                 680                 685            
 Lys Leu Ser Asn Glu Glu Ile Arg Gln Ala Ile Leu Lys Met Asp Glu
     690                 695                 700                
 Gln Glu Asp Leu Ala Lys Asp Met Leu Glu Gln Leu Leu Lys Phe Ile
 705                 710                 715                 720
 Pro Glu Lys Ser Asp Ile Asp Leu Leu Glu Glu His Lys His Glu Ile
                 725                 730                 735    
 Glu Arg Met Ala Arg Ala Asp Arg Phe Leu Tyr Glu Met Ser Arg Ile
             740                 745                 750        
 Asp His Tyr Gln Gln Arg Leu Gln Ala Leu Phe Phe Lys Lys Lys Phe
         755                 760                 765            
 Gln Glu Arg Leu Ala Glu Ala Lys Pro Lys Val Glu Ala Ile Leu Leu
     770                 775                 780                
 Ala Ser Arg Glu Leu Val Arg Ser Lys Arg Leu Arg Gln Met Leu Glu
 785                 790                 795                 800
 Val Ile Leu Ala Ile Gly Asn Phe Met Asn Lys Gly Gln Arg Gly Gly
                 805                 810                 815    
 Ala Tyr Gly Phe Arg Val Ala Ser Leu Asn Lys Ile Ala Asp Thr Lys
             820                 825                 830        
 Ser Ser Ile Asp Arg Asn Ile Ser Leu Leu His Tyr Leu Ile Met Ile
         835                 840                 845            
 Leu Glu Lys His Phe Pro Asp Ile Leu Asn Met Pro Ser Glu Leu Gln
     850                 855                 860                
 His Leu Pro Glu Ala Ala Lys Val Asn Leu Ala Glu Leu Glu Lys Glu
 865                 870                 875                 880
 Val Gly Asn Leu Arg Arg Gly Leu Arg Ala Val Glu Val Glu Leu Glu
                 885                 890                 895    
 Tyr Gln Arg Arg Gln Val Arg Glu Pro Ser Asp Lys Phe Val Pro Val
             900                 905                 910        
 Met Ser Asp Phe Ile Thr Val Ser Ser Phe Ser Phe Ser Glu Leu Glu
         915                 920                 925            
 Asp Gln Leu Asn Glu Ala Arg Asp Lys Phe Ala Lys Ala Leu Met His
     930                 935                 940                
 Phe Gly Glu His Asp Ser Lys Met Gln Pro Asp Glu Phe Phe Gly Ile
 945                 950                 955                 960
 Phe Asp Thr Phe Leu Gln Ala Phe Ser Glu Ala Arg Gln Asp Leu Glu
                 965                 970                 975    
 Ala Met Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Ala Arg Met Glu
             980                 985                 990        
 Ala Met Leu Lys Glu Gln Arg Glu Arg Glu Arg Trp Gln Arg Gln Arg
         995                1000                1005            
 Lys Val Leu Ala Ala Gly Ser Ser Leu Glu Glu Gly Gly Glu Phe Asp
    1010                1015                1020                
 Asp Leu Val Ser Ala Leu Arg Ser Gly Glu Val Phe Asp Lys Asp Leu
1025                1030                1035                1040
 Cys Lys Leu Lys Arg Ser Arg Lys Arg Ser Gly Ser Gln Ala Leu Glu
                1045                1050                1055    
 Val Thr Arg Glu Arg Ala Ile Asn Arg Leu Asn Tyr
            1060                1065            



      <210> 1044
      <211> 645
      <212> PRT
      <213> Homo sapiens


      <400> 1044
 Met Thr Cys Phe Gln Glu Leu Val Thr Phe Arg Asp Val Ala Ile Asp
   1               5                  10                  15    
 Phe Ser Arg Gln Glu Trp Glu Tyr Leu Asp Pro Asn Gln Arg Asp Leu
              20                  25                  30        
 Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Val Ser Leu Gly
          35                  40                  45            
 Gly His Ser Ile Ser Lys Pro Val Val Val Asp Leu Leu Glu Arg Gly
      50                  55                  60                
 Lys Glu Pro Trp Met Ile Leu Arg Glu Glu Thr Gln Phe Thr Asp Leu
  65                  70                  75                  80
 Asp Leu Gln Cys Glu Ile Ile Ser Tyr Ile Glu Val Pro Thr Tyr Glu
                  85                  90                  95    
 Thr Asp Ile Ser Ser Thr Gln Leu Gln Ser Ile Tyr Lys Arg Glu Lys
             100                 105                 110        
 Leu Tyr Glu Cys Lys Lys Cys Gln Lys Lys Phe Ser Ser Gly Tyr Gln
         115                 120                 125            
 Leu Ile Leu His His Arg Phe His Val Ile Glu Arg Pro Tyr Glu Cys
     130                 135                 140                
 Lys Glu Cys Gly Lys Asn Phe Arg Ser Gly Tyr Gln Leu Thr Leu His
 145                 150                 155                 160
 Gln Arg Phe His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly
                 165                 170                 175    
 Lys Asn Phe Arg Ser Gly Tyr Gln Leu Thr Val His Gln Arg Phe His
             180                 185                 190        
 Thr Gly Glu Lys Thr Tyr Glu Cys Arg Gln Cys Gly Lys Ala Phe Ile
         195                 200                 205            
 Tyr Ala Ser His Ile Val Gln His Glu Arg Ile His Thr Gly Gly Lys
     210                 215                 220                
 Pro Tyr Glu Cys Gln Glu Cys Gly Arg Ala Phe Ser Gln Gly Gly His
 225                 230                 235                 240
 Leu Arg Ile His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys
                 245                 250                 255    
 Lys Glu Cys Gly Lys Thr Phe Ser Arg Arg Ser Asn Leu Val Glu His
             260                 265                 270        
 Gly Gln Phe His Thr Asp Glu Lys Pro Tyr Ile Cys Glu Lys Cys Gly
         275                 280                 285            
 Lys Ala Phe Arg Arg Gly His Gln Leu Thr Val His Gln Arg Val His
     290                 295                 300                
 Thr Gly Lys Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Gly Tyr Thr
 305                 310                 315                 320
 Thr Ala Ser Tyr Phe Leu Leu His Gln Arg Ile His Lys Gly Gly Lys
                 325                 330                 335    
 Pro Tyr Glu Cys Lys Glu Cys Lys Lys Thr Phe Thr Leu Tyr Arg Asn
             340                 345                 350        
 Leu Thr Arg His Gln Asn Ile His Thr Gly Glu Lys Leu Phe Glu Cys
         355                 360                 365            
 Lys Gln Cys Gly Lys Thr Tyr Thr Thr Gly Ser Lys Leu Phe Gln His
     370                 375                 380                
 Gln Lys Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly
 385                 390                 395                 400
 Lys Ala Phe Ser Leu Tyr Gly Tyr Leu Lys Gln His Gln Lys Ile His
                 405                 410                 415    
 Thr Gly Met Lys His Phe Glu Cys Lys Glu Cys Lys Lys Thr Phe Thr
             420                 425                 430        
 Leu Tyr Arg Asn Leu Thr Arg His Gln Asn Ile His Thr Gly Lys Lys
         435                 440                 445            
 Leu Phe Glu Cys Gln Glu Cys Gly Lys Ala Tyr Ser Thr Gly Ser Asn
     450                 455                 460                
 Leu Ile Gln His Arg Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys
 465                 470                 475                 480
 Lys Glu Cys Gly Lys Thr Phe Ser Leu His Gly Tyr Leu Asn Gln His
                 485                 490                 495    
 Gln Lys Ile His Thr Gly Val Lys Pro Tyr Glu Cys Lys Val Cys Arg
             500                 505                 510        
 Lys Thr Phe Thr Phe Tyr Arg Asn Leu Thr Leu His Gln Ser Ile His
         515                 520                 525            
 Thr Asp Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Thr Phe Arg
     530                 535                 540                
 Arg Ser Ser His Leu Thr Ala His Gln Ser Ile His Ala Asp Lys Lys
 545                 550                 555                 560
 Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Lys Met Tyr Gly Tyr
                 565                 570                 575    
 Leu Thr Gln His Gln Lys Ile His Thr Gly Gly Lys Pro Tyr Glu Cys
             580                 585                 590        
 Lys Glu Cys Gly Lys Ala Phe Ser Arg Ala Ser Asn Leu Val Gln His
         595                 600                 605            
 Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys Lys Gln Cys Gly
     610                 615                 620                
 Lys Thr Phe Arg Tyr Gly Ser Ala Leu Lys Ala His Gln Arg Ile His
 625                 630                 635                 640
 Arg Ser Ile Lys Val
                 645



      <210> 1045
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 1045
 Met Glu Pro Pro Ile Pro Gln Ser Ala Pro Leu Thr Pro Asn Ser Val
   1               5                  10                  15    
 Met Val Gln Pro Leu Leu Asp Ser Arg Met Ser His Ser Arg Leu Gln
              20                  25                  30        
 His Pro Leu Thr Ile Leu Pro Ile Asp Gln Val Lys Thr Ser His Val
          35                  40                  45            
 Glu Asn Asp Tyr Ile Asp Asn Pro Ser Leu Ala Leu Thr Thr Gly Pro
      50                  55                  60                
 Lys Arg Thr Arg Gly Gly Ala Pro Lys Leu Ala Gln Arg Gly Tyr Asp
  65                  70                  75                  80
 Arg Leu Arg Arg Pro Gly Cys Arg Cys Lys His Thr Asn Ser Val Ile
                  85                  90                  95    
 Cys Lys Ala Ala Ser Gly Asp Ala Lys Thr Ser Arg Pro Asp Lys Pro
             100                 105                 110        
 Phe
    



      <210> 1046
      <211> 740
      <212> PRT
      <213> Homo sapiens


      <400> 1046
 Met Ala Glu Ser Arg Gly Arg Leu Tyr Leu Trp Met Cys Leu Ala Ala
   1               5                  10                  15    
 Ala Leu Ala Ser Phe Leu Met Gly Phe Met Val Gly Trp Phe Ile Lys
              20                  25                  30        
 Pro Leu Lys Glu Thr Thr Thr Ser Val Arg Tyr His Gln Ser Ile Arg
          35                  40                  45            
 Trp Lys Leu Val Ser Glu Met Lys Ala Glu Asn Ile Lys Ser Phe Leu
      50                  55                  60                
 Arg Ser Phe Thr Lys Leu Pro His Leu Ala Gly Thr Glu Gln Asn Phe
  65                  70                  75                  80
 Leu Leu Ala Lys Lys Ile Gln Thr Gln Trp Lys Lys Phe Gly Leu Asp
                  85                  90                  95    
 Ser Ala Lys Leu Val His Tyr Asp Val Leu Leu Ser Tyr Pro Asn Glu
             100                 105                 110        
 Thr Asn Ala Asn Tyr Ile Ser Ile Val Asp Glu His Glu Thr Glu Ile
         115                 120                 125            
 Phe Lys Thr Ser Tyr Leu Glu Pro Pro Pro Asp Gly Tyr Glu Asn Val
     130                 135                 140                
 Thr Asn Ile Val Pro Pro Tyr Asn Ala Phe Ser Ala Gln Gly Met Pro
 145                 150                 155                 160
 Glu Gly Asp Leu Val Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe
                 165                 170                 175    
 Lys Leu Glu Arg Glu Met Gly Ile Asn Cys Thr Gly Lys Ile Val Ile
             180                 185                 190        
 Ala Arg Tyr Gly Lys Ile Phe Arg Gly Asn Lys Val Lys Asn Ala Met
         195                 200                 205            
 Leu Ala Gly Ala Ile Gly Ile Ile Leu Tyr Ser Asp Pro Ala Asp Tyr
     210                 215                 220                
 Phe Ala Pro Glu Val Gln Pro Tyr Pro Lys Gly Trp Asn Leu Pro Gly
 225                 230                 235                 240
 Thr Ala Ala Gln Arg Gly Asn Val Leu Asn Leu Asn Gly Ala Gly Asp
                 245                 250                 255    
 Pro Leu Thr Pro Gly Tyr Pro Ala Lys Glu Tyr Thr Phe Arg Leu Asp
             260                 265                 270        
 Val Glu Glu Gly Val Gly Ile Pro Arg Ile Pro Val His Pro Ile Gly
         275                 280                 285            
 Tyr Asn Asp Ala Glu Ile Leu Leu Arg Tyr Leu Gly Gly Ile Ala Pro
     290                 295                 300                
 Pro Asp Lys Ser Trp Lys Gly Ala Leu Asn Val Ser Tyr Ser Ile Gly
 305                 310                 315                 320
 Pro Gly Phe Thr Gly Ser Asp Ser Phe Arg Lys Val Arg Met His Val
                 325                 330                 335    
 Tyr Asn Ile Asn Lys Ile Thr Arg Ile Tyr Asn Val Val Gly Thr Ile
             340                 345                 350        
 Arg Gly Ser Val Glu Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg
         355                 360                 365            
 Asp Ser Trp Val Phe Gly Ala Ile Asp Pro Thr Ser Gly Val Ala Val
     370                 375                 380                
 Leu Gln Glu Ile Ala Arg Ser Phe Gly Lys Leu Met Ser Lys Gly Trp
 385                 390                 395                 400
 Arg Pro Arg Arg Thr Ile Ile Phe Ala Ser Trp Asp Ala Glu Glu Phe
                 405                 410                 415    
 Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu Glu Asn Val Lys Ile Leu
             420                 425                 430        
 Gln Glu Arg Ser Ile Ala Tyr Ile Asn Ser Asp Ser Ser Ile Glu Gly
         435                 440                 445            
 Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro Leu Leu Tyr Gln Leu Val
     450                 455                 460                
 Tyr Lys Leu Thr Lys Glu Ile Pro Ser Pro Asp Asp Gly Phe Glu Ser
 465                 470                 475                 480
 Lys Ser Leu Tyr Glu Ser Trp Leu Glu Lys Asp Pro Ser Pro Glu Asn
                 485                 490                 495    
 Lys Asn Leu Pro Arg Ile Asn Lys Leu Gly Ser Gly Ser Asp Phe Glu
             500                 505                 510        
 Ala Tyr Phe Gln Arg Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr
         515                 520                 525            
 Lys Asn Lys Lys Thr Asp Lys Tyr Ser Ser Tyr Pro Val Tyr His Thr
     530                 535                 540                
 Ile Tyr Glu Thr Phe Glu Leu Val Glu Lys Phe Tyr Asp Pro Thr Phe
 545                 550                 555                 560
 Lys Lys Gln Leu Ser Val Ala Gln Leu Arg Gly Ala Leu Val Tyr Glu
                 565                 570                 575    
 Leu Val Asp Ser Lys Ile Ile Pro Phe Asn Ile Gln Asp Tyr Ala Glu
             580                 585                 590        
 Ala Leu Lys Asn Tyr Ala Ala Ser Ile Tyr Asn Leu Ser Lys Lys His
         595                 600                 605            
 Asp Gln Gln Leu Thr Asp His Gly Val Ser Phe Asp Ser Leu Phe Ser
     610                 615                 620                
 Ala Val Lys Asn Phe Ser Glu Ala Ala Ser Asp Phe His Lys Arg Leu
 625                 630                 635                 640
 Ile Gln Val Asp Leu Asn Asn Pro Ile Ala Val Arg Met Met Asn Asp
                 645                 650                 655    
 Gln Leu Met Leu Leu Glu Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro
             660                 665                 670        
 Gly Lys Leu Phe Tyr Arg His Ile Ile Phe Ala Pro Ser Ser His Asn
         675                 680                 685            
 Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile Tyr Asp Ala Ile Phe Asp
     690                 695                 700                
 Ile Glu Asn Lys Ala Asn Ser Arg Leu Ala Trp Lys Glu Val Lys Lys
 705                 710                 715                 720
 His Ile Ser Ile Ala Ala Phe Thr Ile Gln Ala Ala Ala Gly Thr Leu
                 725                 730                 735    
 Lys Glu Val Leu
             740



      <210> 1047
      <211> 287
      <212> PRT
      <213> Homo sapiens


      <400> 1047
 Met Ala Glu Arg Gly Leu Glu Pro Ser Pro Ala Ala Val Ala Ala Leu
   1               5                  10                  15    
 Pro Pro Glu Val Arg Ala Gln Leu Ala Glu Leu Glu Leu Glu Leu Ser
              20                  25                  30        
 Glu Gly Asp Ile Thr Gln Lys Gly Tyr Glu Lys Lys Arg Ser Lys Leu
          35                  40                  45            
 Leu Ser Pro Tyr Ser Pro Gln Thr Gln Glu Thr Asp Ser Ala Val Gln
      50                  55                  60                
 Lys Glu Leu Arg Asn Gln Thr Pro Ala Pro Ser Ala Ala Gln Thr Ser
  65                  70                  75                  80
 Ala Pro Ser Lys Tyr His Arg Thr Arg Ser Gly Gly Ala Arg Asp Glu
                  85                  90                  95    
 Arg Tyr Arg Ser Asp Ile His Thr Glu Ala Val Gln Ala Ala Leu Ala
             100                 105                 110        
 Lys His Lys Glu Gln Lys Met Ala Leu Pro Met Pro Thr Lys Arg Arg
         115                 120                 125            
 Ser Thr Phe Val Gln Ser Pro Ala Asp Ala Cys Thr Pro Pro Asp Thr
     130                 135                 140                
 Ser Ser Ala Ser Glu Asp Glu Gly Ser Leu Arg Arg Gln Ala Ala Leu
 145                 150                 155                 160
 Ser Ala Ala Leu Gln Gln Ser Leu Gln Asn Ala Glu Ser Trp Ile Asn
                 165                 170                 175    
 Arg Ser Ile Gln Gly Ser Ser Thr Ser Ser Ser Ala Ser Ser Thr Leu
             180                 185                 190        
 Ser His Gly Glu Val Lys Gly Thr Ser Gly Ser Leu Ala Asp Val Phe
         195                 200                 205            
 Ala Asn Thr Arg Ile Glu Asn Phe Ser Ala Pro Pro Asp Val Thr Thr
     210                 215                 220                
 Thr Thr Ser Ser Ser Ser Ser Ser Ser Ser Ile Arg Pro Ala Asn Ile
 225                 230                 235                 240
 Asp Leu Pro Pro Ser Gly Ile Val Lys Gly Met His Lys Gly Ser Asn
                 245                 250                 255    
 Arg Ser Ser Leu Met Asp Thr Ala Asp Gly Val Pro Val Ser Ser Arg
             260                 265                 270        
 Val Ser Thr Lys Ile Gln Gln Leu Leu Asn Thr Leu Lys Arg Pro
         275                 280                 285        



      <210> 1048
      <211> 1838
      <212> PRT
      <213> Homo sapiens


      <400> 1048
 Met Ala Leu Gln Leu Trp Ala Leu Thr Leu Leu Gly Leu Leu Gly Ala
   1               5                  10                  15    
 Gly Ala Ser Leu Arg Pro Arg Lys Leu Asp Phe Phe Arg Ser Glu Lys
              20                  25                  30        
 Glu Leu Asn His Leu Ala Val Asp Glu Ala Ser Gly Val Val Tyr Leu
          35                  40                  45            
 Gly Ala Val Asn Ala Leu Tyr Gln Leu Asp Ala Lys Leu Gln Leu Glu
      50                  55                  60                
 Gln Gln Val Ala Thr Gly Pro Ala Leu Asp Asn Lys Lys Cys Thr Pro
  65                  70                  75                  80
 Pro Ile Glu Ala Ser Gln Cys His Glu Ala Glu Met Thr Asp Asn Val
                  85                  90                  95    
 Asn Gln Leu Leu Leu Leu Asp Pro Pro Arg Lys Arg Leu Val Glu Cys
             100                 105                 110        
 Gly Ser Leu Phe Lys Gly Ile Cys Ala Leu Arg Ala Leu Ser Asn Ile
         115                 120                 125            
 Ser Leu Arg Leu Phe Tyr Glu Asp Gly Ser Gly Glu Lys Ser Phe Val
     130                 135                 140                
 Ala Ser Asn Asp Glu Gly Val Ala Thr Val Gly Leu Val Ser Ser Thr
 145                 150                 155                 160
 Gly Pro Gly Gly Asp Arg Val Leu Phe Val Gly Lys Gly Asn Gly Pro
                 165                 170                 175    
 His Asp Asn Gly Ile Ile Val Ser Thr Arg Leu Leu Asp Arg Thr Asp
             180                 185                 190        
 Ser Arg Glu Ala Phe Glu Ala Tyr Thr Asp His Ala Thr Tyr Lys Ala
         195                 200                 205            
 Gly Tyr Leu Ser Thr Asn Thr Gln Gln Phe Val Ala Ala Phe Glu Asp
     210                 215                 220                
 Gly Pro Tyr Val Phe Phe Val Phe Asn Gln Gln Asp Lys His Pro Ala
 225                 230                 235                 240
 Arg Asn Arg Thr Leu Leu Ala Arg Met Cys Arg Glu Asp Pro Asn Tyr
                 245                 250                 255    
 Tyr Ser Tyr Leu Glu Met Asp Leu Gln Cys Arg Asp Pro Asp Ile His
             260                 265                 270        
 Ala Ala Ala Phe Gly Thr Cys Leu Ala Ala Ser Val Ala Ala Pro Gly
         275                 280                 285            
 Ser Gly Arg Val Leu Tyr Ala Val Phe Ser Arg Asp Ser Arg Ser Ser
     290                 295                 300                
 Gly Gly Pro Gly Ala Gly Leu Cys Leu Phe Pro Leu Asp Glu Val His
 305                 310                 315                 320
 Ala Lys Met Glu Ala Asn Arg Asn Ala Cys Tyr Thr Gly Thr Arg Glu
                 325                 330                 335    
 Ala Arg Asp Ile Phe Tyr Lys Pro Phe His Gly Asp Ile Gln Cys Gly
             340                 345                 350        
 Gly His Ala Pro Gly Ser Ser Lys Ser Phe Pro Cys Gly Ser Glu His
         355                 360                 365            
 Leu Pro Tyr Pro Leu Gly Ser Arg Asp Gly Leu Arg Gly Thr Ala Val
     370                 375                 380                
 Leu Gln Arg Gly Gly Leu Asn Leu Thr Ala Val Thr Val Ala Ala Glu
 385                 390                 395                 400
 Asn Asn His Thr Val Ala Phe Leu Gly Thr Ser Asp Gly Arg Ile Leu
                 405                 410                 415    
 Lys Val Tyr Leu Thr Pro Asp Gly Thr Ser Ser Glu Tyr Asp Ser Ile
             420                 425                 430        
 Leu Val Glu Ile Asn Lys Arg Val Lys Arg Asp Leu Val Leu Ser Gly
         435                 440                 445            
 Asp Leu Gly Ser Leu Tyr Ala Met Thr Gln Asp Lys Val Phe Arg Leu
     450                 455                 460                
 Pro Val Gln Glu Cys Leu Ser Tyr Pro Thr Cys Thr Gln Cys Arg Asp
 465                 470                 475                 480
 Ser Gln Asp Pro Tyr Cys Gly Trp Cys Val Val Glu Gly Arg Cys Thr
                 485                 490                 495    
 Arg Lys Ala Glu Cys Pro Arg Ala Glu Glu Ala Ser His Trp Leu Trp
             500                 505                 510        
 Ser Arg Ser Lys Ser Cys Val Ala Val Thr Ser Ala Gln Pro Gln Asn
         515                 520                 525            
 Met Ser Arg Arg Ala Gln Gly Glu Val Gln Leu Thr Val Ser Pro Leu
     530                 535                 540                
 Pro Ala Leu Ser Glu Glu Asp Glu Leu Leu Cys Leu Phe Gly Glu Ser
 545                 550                 555                 560
 Pro Pro His Pro Ala Arg Val Glu Gly Glu Ala Val Ile Cys Asn Ser
                 565                 570                 575    
 Pro Ser Ser Ile Pro Val Thr Pro Pro Gly Gln Asp His Val Ala Val
             580                 585                 590        
 Thr Ile Gln Leu Leu Leu Arg Arg Gly Asn Ile Phe Leu Thr Ser Tyr
         595                 600                 605            
 Gln Tyr Pro Phe Tyr Asp Cys Arg Gln Ala Met Ser Leu Glu Glu Asn
     610                 615                 620                
 Leu Pro Cys Ile Ser Cys Val Ser Asn Arg Trp Thr Cys Gln Trp Asp
 625                 630                 635                 640
 Leu Arg Tyr His Glu Cys Arg Glu Ala Ser Pro Asn Pro Glu Asp Gly
                 645                 650                 655    
 Ile Val Arg Ala His Met Glu Asp Ser Cys Pro Gln Phe Leu Gly Pro
             660                 665                 670        
 Ser Pro Leu Val Ile Pro Met Asn His Glu Thr Asp Val Asn Phe Gln
         675                 680                 685            
 Gly Lys Asn Leu Asp Thr Val Lys Gly Ser Ser Leu His Val Gly Ser
     690                 695                 700                
 Asp Leu Leu Lys Phe Met Glu Pro Val Thr Met Gln Glu Ser Gly Thr
 705                 710                 715                 720
 Phe Ala Phe Arg Thr Pro Lys Leu Ser His Asp Ala Asn Glu Thr Leu
                 725                 730                 735    
 Pro Leu His Leu Tyr Val Lys Ser Tyr Gly Lys Asn Ile Asp Ser Lys
             740                 745                 750        
 Leu His Val Thr Leu Tyr Asp Cys Ser Phe Gly Arg Ser Asp Cys Ser
         755                 760                 765            
 Leu Cys Arg Ala Ala Asn Pro Asp Tyr Arg Cys Ala Trp Cys Gly Gly
     770                 775                 780                
 Gln Ser Arg Cys Val Tyr Glu Ala Leu Cys Asn Thr Thr Ser Glu Cys
 785                 790                 795                 800
 Pro Pro Pro Val Ile Thr Arg Ile Gln Pro Glu Thr Gly Pro Leu Gly
                 805                 810                 815    
 Gly Gly Ile Arg Ile Thr Ile Leu Gly Ser Asn Leu Gly Val Gln Ala
             820                 825                 830        
 Gly Asp Ile Gln Arg Ile Ser Val Ala Gly Arg Asn Cys Ser Phe Gln
         835                 840                 845            
 Pro Glu Arg Tyr Ser Val Ser Thr Arg Ile Val Cys Val Ile Glu Ala
     850                 855                 860                
 Ala Glu Thr Pro Phe Thr Gly Gly Val Glu Val Asp Val Phe Gly Lys
 865                 870                 875                 880
 Leu Gly Arg Ser Pro Pro Asn Val Gln Phe Thr Phe Gln Gln Pro Lys
                 885                 890                 895    
 Pro Leu Ser Val Glu Pro Gln Gln Gly Pro Gln Ala Gly Gly Thr Thr
             900                 905                 910        
 Leu Thr Ile His Gly Thr His Leu Asp Thr Gly Ser Gln Glu Asp Val
         915                 920                 925            
 Arg Val Thr Leu Asn Gly Val Pro Cys Lys Val Thr Lys Phe Gly Ala
     930                 935                 940                
 Gln Leu Gln Cys Val Thr Gly Pro Gln Ala Thr Arg Gly Gln Met Leu
 945                 950                 955                 960
 Leu Glu Val Ser Tyr Gly Gly Ser Pro Val Pro Asn Pro Gly Ile Phe
                 965                 970                 975    
 Phe Thr Tyr Arg Glu Asn Pro Val Leu Arg Ala Phe Glu Pro Leu Arg
             980                 985                 990        
 Ser Phe Ala Ser Gly Gly Arg Ser Ile Asn Val Thr Gly Gln Gly Phe
         995                1000                1005            
 Ser Leu Ile Gln Arg Phe Ala Met Val Val Ile Ala Glu Pro Leu Gln
    1010                1015                1020                
 Ser Trp Gln Pro Pro Arg Glu Ala Glu Ser Leu Gln Pro Met Thr Val
1025                1030                1035                1040
 Val Gly Thr Asp Tyr Val Phe His Asn Asp Thr Lys Val Val Phe Leu
                1045                1050                1055    
 Ser Pro Ala Val Pro Glu Glu Pro Glu Ala Tyr Asn Leu Thr Val Leu
            1060                1065                1070        
 Ile Glu Met Asp Gly His Arg Ala Leu Leu Arg Thr Glu Ala Gly Ala
        1075                1080                1085            
 Phe Glu Tyr Val Pro Asp Pro Thr Phe Glu Asn Phe Thr Gly Gly Val
    1090                1095                1100                
 Lys Lys Gln Val Asn Lys Leu Ile His Ala Arg Gly Thr Asn Leu Asn
1105                1110                1115                1120
 Lys Ala Met Thr Leu Gln Glu Ala Glu Ala Phe Val Gly Ala Glu Arg
                1125                1130                1135    
 Cys Thr Met Lys Thr Leu Thr Glu Thr Asp Leu Tyr Cys Glu Pro Pro
            1140                1145                1150        
 Glu Val Gln Pro Pro Pro Lys Arg Arg Gln Lys Arg Asp Thr Thr His
        1155                1160                1165            
 Asn Leu Pro Glu Phe Ile Val Lys Phe Gly Ser Arg Glu Trp Val Leu
    1170                1175                1180                
 Gly Arg Val Glu Tyr Asp Thr Arg Val Ser Asp Val Pro Leu Ser Leu
1185                1190                1195                1200
 Ile Leu Pro Leu Val Ile Val Pro Met Val Val Val Ile Ala Val Ser
                1205                1210                1215    
 Val Tyr Cys Tyr Trp Arg Lys Ser Gln Gln Ala Glu Arg Glu Tyr Glu
            1220                1225                1230        
 Lys Ile Lys Ser Gln Leu Glu Gly Leu Glu Glu Ser Val Arg Asp Arg
        1235                1240                1245            
 Cys Lys Lys Glu Phe Thr Asp Leu Met Ile Glu Met Glu Asp Gln Thr
    1250                1255                1260                
 Asn Asp Val His Glu Ala Gly Ile Pro Val Leu Asp Tyr Lys Thr Tyr
1265                1270                1275                1280
 Thr Asp Arg Val Phe Phe Leu Pro Ser Lys Asp Gly Asp Lys Asp Val
                1285                1290                1295    
 Met Ile Thr Gly Lys Leu Asp Ile Pro Glu Pro Arg Arg Pro Val Val
            1300                1305                1310        
 Glu Gln Ala Leu Tyr Gln Phe Ser Asn Leu Leu Asn Ser Lys Ser Phe
        1315                1320                1325            
 Leu Ile Asn Phe Ile His Thr Leu Glu Asn Gln Arg Glu Phe Ser Ala
    1330                1335                1340                
 Arg Ala Lys Val Tyr Phe Ala Ser Leu Leu Thr Val Ala Leu His Gly
1345                1350                1355                1360
 Lys Leu Glu Tyr Tyr Thr Asp Ile Met His Thr Leu Phe Leu Glu Leu
                1365                1370                1375    
 Leu Glu Gln Tyr Val Val Ala Lys Asn Pro Lys Leu Met Leu Arg Arg
            1380                1385                1390        
 Ser Glu Thr Val Val Glu Arg Met Leu Ser Asn Trp Met Ser Ile Cys
        1395                1400                1405            
 Leu Tyr Gln Tyr Leu Lys Asp Ser Ala Gly Glu Pro Leu Tyr Lys Leu
    1410                1415                1420                
 Phe Lys Ala Ile Lys His Gln Val Glu Lys Gly Pro Val Asp Ala Val
1425                1430                1435                1440
 Gln Lys Lys Ala Lys Tyr Thr Leu Asn Asp Thr Gly Leu Leu Gly Asp
                1445                1450                1455    
 Asp Val Glu Tyr Ala Pro Leu Thr Val Ser Val Ile Val Gln Asp Glu
            1460                1465                1470        
 Gly Val Asp Ala Ile Pro Val Lys Val Leu Asn Cys Asp Thr Ile Ser
        1475                1480                1485            
 Gln Val Lys Glu Lys Ile Ile Asp Gln Val Tyr Arg Gly Gln Pro Cys
    1490                1495                1500                
 Ser Cys Trp Pro Arg Pro Asp Ser Val Val Leu Glu Trp Arg Pro Gly
1505                1510                1515                1520
 Ser Thr Ala Gln Ile Leu Ser Asp Leu Asp Leu Thr Ser Gln Arg Glu
                1525                1530                1535    
 Gly Arg Trp Lys Arg Val Asn Thr Leu Met His Tyr Asn Val Arg Asp
            1540                1545                1550        
 Gly Ala Thr Leu Ile Leu Ser Lys Val Gly Val Ser Gln Gln Pro Glu
        1555                1560                1565            
 Asp Ser Gln Gln Asp Leu Pro Gly Glu Arg His Ala Leu Leu Glu Glu
    1570                1575                1580                
 Glu Asn Arg Val Trp His Leu Val Arg Pro Thr Asp Glu Val Asp Glu
1585                1590                1595                1600
 Gly Lys Ser Lys Arg Gly Ser Val Lys Glu Lys Glu Arg Thr Lys Ala
                1605                1610                1615    
 Ile Thr Glu Ile Tyr Leu Thr Arg Leu Leu Ser Val Lys Gly Thr Leu
            1620                1625                1630        
 Gln Gln Phe Val Asp Asn Phe Phe Gln Ser Val Leu Ala Pro Gly His
        1635                1640                1645            
 Ala Val Pro Pro Ala Val Lys Tyr Phe Phe Asp Phe Leu Asp Glu Gln
    1650                1655                1660                
 Ala Glu Lys His Asn Ile Gln Asp Glu Asp Thr Ile His Ile Trp Lys
1665                1670                1675                1680
 Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys Asn Pro
                1685                1690                1695    
 His Phe Ile Phe Asp Val His Val His Glu Val Val Asp Ala Ser Leu
            1700                1705                1710        
 Ser Val Ile Ala Gln Thr Phe Met Asp Ala Cys Thr Arg Thr Glu His
        1715                1720                1725            
 Lys Leu Ser Arg Asp Ser Pro Ser Asn Lys Leu Leu Tyr Ala Lys Glu
    1730                1735                1740                
 Ile Ser Thr Tyr Lys Lys Met Val Glu Asp Tyr Tyr Lys Gly Ile Arg
1745                1750                1755                1760
 Gln Met Val Gln Val Ser Asp Gln Asp Met Asn Thr His Leu Ala Glu
                1765                1770                1775    
 Ile Ser Arg Ala His Thr Asp Ser Leu Asn Thr Leu Val Ala Leu His
            1780                1785                1790        
 Gln Leu Tyr Gln Tyr Thr Gln Lys Tyr Tyr Asp Glu Ile Ile Asn Ala
        1795                1800                1805            
 Leu Glu Glu Asp Pro Ala Ala Gln Lys Met Gln Leu Ala Phe Arg Leu
    1810                1815                1820                
 Gln Gln Ile Ala Ala Ala Leu Glu Asn Lys Val Thr Asp Leu
1825                1830                1835            



      <210> 1049
      <211> 587
      <212> PRT
      <213> Homo sapiens


      <400> 1049
 Met Ser Gln Met Leu His Ile Glu Ile Pro Asn Phe Gly Asn Thr Val
   1               5                  10                  15    
 Leu Gly Cys Leu Asn Glu Gln Arg Leu Leu Gly Leu Tyr Cys Asp Val
              20                  25                  30        
 Ser Ile Val Val Lys Gly Gln Ala Phe Lys Ala His Arg Ala Val Leu
          35                  40                  45            
 Ala Ala Ser Ser Leu Tyr Phe Arg Asp Leu Phe Ser Gly Asn Ser Lys
      50                  55                  60                
 Ser Ala Phe Glu Leu Pro Gly Ser Val Pro Pro Ala Cys Phe Gln Gln
  65                  70                  75                  80
 Ile Leu Ser Phe Cys Tyr Thr Gly Arg Leu Thr Met Thr Ala Ser Glu
                  85                  90                  95    
 Gln Leu Val Val Met Tyr Thr Ala Gly Phe Leu Gln Ile Gln His Ile
             100                 105                 110        
 Val Glu Arg Gly Thr Asp Leu Met Phe Lys Val Ser Ser Pro His Cys
         115                 120                 125            
 Asp Ser Gln Thr Ala Val Ile Glu Asp Ala Gly Ser Glu Pro Gln Ser
     130                 135                 140                
 Pro Cys Asn Gln Leu Gln Pro Ala Ala Ala Ala Ala Ala Pro Tyr Val
 145                 150                 155                 160
 Val Ser Pro Ser Val Pro Ile Pro Leu Leu Thr Arg Val Lys His Glu
                 165                 170                 175    
 Ala Met Glu Leu Pro Pro Ala Gly Pro Gly Leu Ala Pro Lys Arg Pro
             180                 185                 190        
 Leu Glu Thr Gly Pro Arg Asp Gly Val Ala Val Ala Ala Gly Ala Ala
         195                 200                 205            
 Val Ala Ala Gly Thr Ala Pro Leu Lys Leu Pro Arg Val Ser Tyr Tyr
     210                 215                 220                
 Gly Val Pro Ser Leu Ala Thr Leu Ile Pro Gly Ile Gln Gln Met Pro
 225                 230                 235                 240
 Tyr Pro Gln Gly Glu Arg Thr Ser Pro Gly Ala Ser Ser Leu Pro Thr
                 245                 250                 255    
 Thr Asp Ser Pro Thr Ser Tyr His Asn Glu Glu Asp Glu Glu Asp Asp
             260                 265                 270        
 Glu Ala Tyr Asp Thr Met Val Glu Glu Gln Tyr Gly Gln Met Tyr Ile
         275                 280                 285            
 Lys Ala Ser Gly Ser Tyr Ala Val Gln Glu Lys Pro Glu Pro Val Pro
     290                 295                 300                
 Leu Glu Ser Arg Ser Cys Val Leu Ile Arg Arg Asp Leu Val Ala Leu
 305                 310                 315                 320
 Pro Ala Ser Leu Ile Ser Gln Ile Gly Tyr Arg Cys His Pro Lys Leu
                 325                 330                 335    
 Tyr Ser Glu Gly Asp Pro Gly Glu Lys Leu Glu Leu Val Ala Gly Ser
             340                 345                 350        
 Gly Val Tyr Ile Thr Arg Gly Gln Leu Met Asn Cys His Leu Cys Ala
         355                 360                 365            
 Gly Val Lys His Lys Val Leu Leu Arg Arg Leu Leu Ala Thr Phe Phe
     370                 375                 380                
 Asp Arg Asn Thr Leu Ala Asn Ser Cys Gly Thr Gly Ile Arg Ser Ser
 385                 390                 395                 400
 Thr Ser Asp Pro Ser Arg Lys Pro Leu Asp Ser Arg Val Leu Asn Ala
                 405                 410                 415    
 Val Lys Leu Tyr Cys Gln Asn Phe Ala Pro Ser Phe Lys Glu Ser Glu
             420                 425                 430        
 Met Asn Val Ile Ala Ala Asp Met Cys Thr Asn Ala Arg Arg Val Arg
         435                 440                 445            
 Lys Arg Trp Leu Pro Lys Ile Lys Ser Met Leu Pro Glu Gly Val Glu
     450                 455                 460                
 Met Tyr Arg Thr Val Met Gly Ser Ala Ala Ala Ser Val Pro Leu Asp
 465                 470                 475                 480
 Pro Glu Phe Pro Pro Ala Ala Ala Gln Val Phe Glu Gln Arg Ile Tyr
                 485                 490                 495    
 Ala Glu Arg Arg Gly Asp Ala Ala Thr Ile Val Ala Leu Arg Thr Asp
             500                 505                 510        
 Ala Val Asn Val Asp Leu Ser Ala Ala Ala Asn Pro Ala Phe Asp Ala
         515                 520                 525            
 Gly Glu Glu Val Asp Gly Ala Gly Ser Val Ile Gln Glu Val Ala Ala
     530                 535                 540                
 Pro Glu Pro Leu Pro Ala Asp Gly Gln Ser Pro Pro Gln Pro Phe Glu
 545                 550                 555                 560
 Gln Gly Gly Gly Gly Pro Ser Arg Pro Gln Thr Pro Ala Ala Ala Ala
                 565                 570                 575    
 Arg Arg Pro Glu Gly Thr Tyr Ala Gly Thr Leu
             580                 585        



      <210> 1050
      <211> 601
      <212> PRT
      <213> Homo sapiens


      <400> 1050
 Met Pro Trp Thr Ser Pro Ser Cys Gln Asn Ser Cys Glu Leu Gly Ile
   1               5                  10                  15    
 Gln Asn Leu Ser Phe Lys Val Arg Ser Gly Gln Met Leu Ala Ile Ile
              20                  25                  30        
 Gly Ser Ser Gly Cys Gly Arg Ala Ser Leu Leu Asp Val Ile Thr Gly
          35                  40                  45            
 Arg Gly His Gly Gly Lys Ile Lys Ser Gly Gln Ile Trp Ile Asn Gly
      50                  55                  60                
 Gln Pro Ser Ser Pro Gln Leu Val Arg Lys Cys Val Ala His Val Arg
  65                  70                  75                  80
 Gln His Asn Gln Leu Leu Pro Asn Leu Thr Val Arg Glu Thr Leu Ala
                  85                  90                  95    
 Phe Ile Ala Gln Met Arg Leu Pro Arg Thr Phe Ser Gln Ala Gln Arg
             100                 105                 110        
 Asp Lys Arg Val Glu Asp Val Ile Ala Glu Leu Arg Leu Arg Gln Cys
         115                 120                 125            
 Ala Asp Thr Arg Val Gly Asn Met Tyr Val Arg Gly Leu Ser Gly Gly
     130                 135                 140                
 Glu Arg Arg Arg Val Ser Ile Gly Val Gln Leu Leu Trp Asn Pro Gly
 145                 150                 155                 160
 Ile Leu Ile Leu Asp Glu Pro Thr Ser Gly Leu Asp Ser Phe Thr Ala
                 165                 170                 175    
 His Asn Leu Val Lys Thr Leu Ser Arg Leu Ala Lys Gly Asn Arg Leu
             180                 185                 190        
 Val Leu Ile Ser Leu His Gln Pro Arg Ser Asp Ile Phe Arg Leu Phe
         195                 200                 205            
 Asp Leu Val Leu Leu Met Thr Ser Gly Thr Pro Ile Tyr Leu Gly Ala
     210                 215                 220                
 Ala Gln His Met Val Gln Tyr Phe Thr Ala Ile Gly Tyr Pro Cys Pro
 225                 230                 235                 240
 Arg Tyr Ser Asn Pro Ala Asp Phe Tyr Val Asp Leu Thr Ser Ile Asp
                 245                 250                 255    
 Arg Arg Ser Arg Glu Gln Glu Leu Ala Thr Arg Glu Lys Ala Gln Ser
             260                 265                 270        
 Leu Ala Ala Leu Phe Leu Glu Lys Val Arg Asp Leu Asp Asp Phe Leu
         275                 280                 285            
 Trp Lys Ala Glu Thr Lys Asp Leu Asp Glu Asp Thr Cys Val Glu Ser
     290                 295                 300                
 Ser Val Thr Pro Leu Asp Thr Asn Cys Leu Pro Ser Pro Thr Lys Met
 305                 310                 315                 320
 Pro Gly Ala Val Gln Gln Phe Lys Thr Leu Ile Arg Arg Gln Ile Ser
                 325                 330                 335    
 Asn Asp Phe Arg Asp Leu Pro Thr Leu Leu Ile His Gly Ala Glu Ala
             340                 345                 350        
 Cys Leu Met Ser Met Thr Ile Gly Phe Leu Tyr Phe Gly His Gly Ser
         355                 360                 365            
 Ile Gln Leu Ser Phe Met Asp Thr Ala Ala Leu Leu Phe Met Ile Gly
     370                 375                 380                
 Ala Leu Ile Pro Phe Asn Val Ile Leu Asp Val Ile Ser Lys Cys Tyr
 385                 390                 395                 400
 Ser Glu Arg Ala Met Leu Tyr Tyr Glu Leu Glu Asp Gly Leu Tyr Thr
                 405                 410                 415    
 Thr Gly Pro Tyr Phe Phe Ala Lys Ile Leu Gly Glu Leu Pro Glu His
             420                 425                 430        
 Cys Ala Tyr Ile Ile Ile Tyr Gly Met Pro Thr Tyr Trp Leu Ala Asn
         435                 440                 445            
 Leu Arg Pro Gly Leu Gln Pro Phe Leu Leu His Phe Leu Leu Val Trp
     450                 455                 460                
 Leu Val Val Phe Cys Cys Arg Ile Met Ala Leu Ala Ala Ala Ala Leu
 465                 470                 475                 480
 Leu Pro Thr Phe His Met Ala Ser Phe Phe Ser Asn Ala Leu Tyr Asn
                 485                 490                 495    
 Ser Phe Tyr Leu Ala Gly Gly Phe Met Ile Asn Leu Ser Ser Leu Trp
             500                 505                 510        
 Thr Val Pro Ala Trp Ile Ser Lys Val Ser Phe Leu Arg Trp Cys Phe
         515                 520                 525            
 Glu Gly Leu Met Lys Ile Gln Phe Ser Arg Arg Thr Tyr Lys Met Pro
     530                 535                 540                
 Leu Gly Asn Leu Thr Ile Ala Val Ser Gly Asp Lys Ile Leu Ser Ala
 545                 550                 555                 560
 Met Glu Leu Asp Ser Tyr Pro Leu Tyr Ala Ile Tyr Leu Ile Val Ile
                 565                 570                 575    
 Gly Leu Ser Gly Gly Phe Met Val Leu Tyr Tyr Val Ser Leu Arg Phe
             580                 585                 590        
 Ile Lys Gln Lys Pro Ser Gln Asp Trp
         595                 600    



      <210> 1051
      <211> 381
      <212> PRT
      <213> Homo sapiens


      <400> 1051
 Met Ser Arg His Glu Gly Val Ser Cys Asp Ala Cys Leu Lys Gly Asn
   1               5                  10                  15    
 Phe Arg Gly Arg Arg Tyr Lys Cys Leu Ile Cys Tyr Asp Tyr Asp Leu
              20                  25                  30        
 Cys Ala Ser Cys Tyr Glu Ser Gly Ala Thr Thr Thr Arg His Thr Thr
          35                  40                  45            
 Asp His Pro Met Gln Cys Ile Leu Thr Arg Val Asp Phe Asp Leu Tyr
      50                  55                  60                
 Tyr Gly Gly Glu Ala Phe Ser Val Glu Gln Pro Gln Ser Phe Thr Cys
  65                  70                  75                  80
 Pro Tyr Cys Gly Lys Met Gly Tyr Thr Glu Thr Ser Leu Gln Glu His
                  85                  90                  95    
 Val Thr Ser Glu His Ala Glu Thr Ser Thr Glu Val Ile Cys Pro Ile
             100                 105                 110        
 Cys Ala Ala Leu Pro Gly Gly Asp Pro Asn His Val Thr Asp Asp Phe
         115                 120                 125            
 Ala Ala His Leu Thr Leu Glu His Arg Ala Pro Arg Asp Leu Asp Glu
     130                 135                 140                
 Ser Ser Gly Val Arg His Val Arg Arg Met Phe His Pro Gly Arg Gly
 145                 150                 155                 160
 Leu Gly Gly Pro Arg Ala Arg Arg Ser Asn Met His Phe Thr Ser Ser
                 165                 170                 175    
 Ser Thr Gly Gly Leu Ser Ser Ser Gln Ser Ser Tyr Ser Pro Ser Asn
             180                 185                 190        
 Arg Glu Ala Met Asp Pro Ile Ala Glu Leu Leu Ser Gln Leu Ser Gly
         195                 200                 205            
 Val Arg Arg Ser Ala Gly Gly Gln Leu Asn Ser Ser Gly Pro Ser Ala
     210                 215                 220                
 Ser Gln Leu Gln Gln Leu Gln Met Gln Leu Gln Leu Glu Arg Gln His
 225                 230                 235                 240
 Ala Gln Ala Ala Arg Gln Gln Leu Glu Thr Ala Arg Asn Ala Thr Arg
                 245                 250                 255    
 Arg Thr Asn Thr Ser Ser Val Thr Thr Thr Ile Thr Gln Ser Thr Ala
             260                 265                 270        
 Thr Thr Asn Ile Ala Asn Thr Glu Ser Ser Gln Gln Thr Leu Gln Asn
         275                 280                 285            
 Ser Gln Phe Leu Leu Thr Arg Leu Asn Asp Pro Lys Met Ser Glu Thr
     290                 295                 300                
 Glu Arg Gln Ser Met Glu Ser Glu Arg Ala Asp Arg Ser Leu Phe Val
 305                 310                 315                 320
 Gln Glu Leu Leu Leu Ser Thr Leu Val Arg Glu Glu Ser Ser Ser Ser
                 325                 330                 335    
 Asp Glu Asp Asp Arg Gly Glu Met Ala Asp Phe Gly Ala Met Gly Cys
             340                 345                 350        
 Val Asp Ile Met Pro Leu Asp Val Ala Leu Glu Asn Leu Asn Leu Lys
         355                 360                 365            
 Glu Ser Asn Lys Gly Asn Glu Pro Pro Pro Pro Pro Leu
     370                 375                 380    



      <210> 1052
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 1052
 Met Pro Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr His Ser Ala Val
   1               5                  10                  15    
 Ser Val Val Gln Ala Gly Leu Thr Gln Pro Pro Ser Met Ser Lys Asp
              20                  25                  30        
 Leu Gly Gln Thr Ala Thr Leu Ile Cys Ser Gly Asn Gly Asn Asn Val
          35                  40                  45            
 Gly Asn Gln Gly Ala Ala Trp Leu Gln Leu Gln Gln Gly His Pro Pro
      50                  55                  60                
 Lys Leu Leu Ser His Arg Asn Asn Asn Arg Pro Ser Gly Ile Ser Glu
  65                  70                  75                  80
 Arg Phe Ser Ala Thr Lys Ser Asp Ser Thr Ala Ser Leu Thr Ile Thr
                  85                  90                  95    
 Asp Leu Gln Pro Glu Asp Glu Gly Val Tyr Tyr Cys Ser Ala Trp Asp
             100                 105                 110        
 Ser Thr Leu Arg Ala Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val
         115                 120                 125            
 Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser
     130                 135                 140                
 Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser
 145                 150                 155                 160
 Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Gln Ser Ser
                 165                 170                 175    
 Pro Val Lys Ala Gly Val Lys Thr Thr Thr Pro Phe Gln Gln Ser Asn
             180                 185                 190        
 Asn Lys Tyr Ala Arg Ser Ser Tyr Leu Ser Leu Thr Pro
         195                 200                 205



      <210> 1053
      <211> 357
      <212> PRT
      <213> Homo sapiens


      <400> 1053
 Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro
   1               5                  10                  15    
 Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly
              20                  25                  30        
 Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln
          35                  40                  45            
 Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp
      50                  55                  60                
 Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Gly Pro Ser Gly Thr
  65                  70                  75                  80
 Ser Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys
                  85                  90                  95    
 Gly Tyr Gln Leu Ala Gly Val Glu Ala Gly Tyr Ala Cys Phe Cys Gly
             100                 105                 110        
 Ser Glu Ser Asp Leu Ala Arg Gly Arg Leu Ala Pro Ala Thr Asp Cys
         115                 120                 125            
 Asp Gln Ile Cys Phe Gly His Pro Gly Gln Leu Cys Gly Gly Asp Gly
     130                 135                 140                
 Arg Leu Gly Val Tyr Glu Val Ser Val Gly Ser Cys Gln Gly Asn Trp
 145                 150                 155                 160
 Thr Ala Pro Gln Gly Val Ile Tyr Ser Pro Asp Phe Pro Asp Glu Tyr
                 165                 170                 175    
 Gly Pro Asp Arg Asn Cys Ser Trp Ala Leu Gly Pro Pro Gly Ala Ala
             180                 185                 190        
 Leu Glu Leu Thr Phe Arg Leu Phe Glu Leu Ala Asp Pro Arg Asp Arg
         195                 200                 205            
 Leu Glu Leu Arg Asp Ala Ala Ser Gly Ser Leu Leu Arg Ala Phe Asp
     210                 215                 220                
 Gly Ala Arg Pro Pro Pro Ser Gly Pro Leu Arg Leu Gly Thr Ala Ala
 225                 230                 235                 240
 Leu Leu Leu Thr Phe Arg Ser Asp Ala Arg Gly His Ala Gln Gly Phe
                 245                 250                 255    
 Ala Leu Thr Tyr Arg Gly Leu Gln Asp Ala Ala Glu Asp Pro Glu Ala
             260                 265                 270        
 Pro Glu Gly Ser Ala Gln Thr Pro Ala Ala Pro Leu Asp Gly Ala Asn
         275                 280                 285            
 Val Ser Cys Ser Pro Arg Pro Gly Ala Pro Pro Ala Ala Ile Gly Gly
     290                 295                 300                
 Ala Val Cys Trp Leu Arg Glu Lys Gly Pro Arg Arg Trp Gly Leu Pro
 305                 310                 315                 320
 Gly Ala Pro Gly Glu Ala Gly Leu Cys Gly Thr Asn Ser Pro Glu Gly
                 325                 330                 335    
 Trp Pro Cys Pro Ala Pro Pro Gly Thr Pro Arg Leu Arg Val Leu Pro
             340                 345                 350        
 Arg Ala Thr Gly Leu
         355        



      <210> 1054
      <211> 201
      <212> PRT
      <213> Homo sapiens


      <400> 1054
 Met Thr Gln Arg Ala Gly Ala Ala Met Leu Pro Ser Ala Leu Leu Leu
   1               5                  10                  15    
 Leu Cys Val Pro Gly Cys Leu Thr Val Ser Gly Pro Ser Thr Val Met
              20                  25                  30        
 Gly Ala Val Gly Glu Ser Leu Ser Val Gln Cys Arg Tyr Glu Glu Lys
          35                  40                  45            
 Tyr Lys Thr Phe Asn Lys Tyr Trp Cys Arg Gln Pro Cys Leu Pro Ile
      50                  55                  60                
 Trp His Glu Met Val Glu Thr Gly Gly Ser Glu Gly Val Val Arg Ser
  65                  70                  75                  80
 Asp Gln Val Ile Ile Thr Asp His Pro Gly Asp Leu Thr Phe Thr Val
                  85                  90                  95    
 Thr Leu Glu Asn Leu Thr Ala Asp Asp Ala Gly Lys Tyr Arg Cys Gly
             100                 105                 110        
 Ile Ala Thr Ile Leu Gln Glu Asp Gly Leu Ser Gly Phe Leu Pro Asp
         115                 120                 125            
 Pro Phe Phe Gln Val Gln Val Leu Val Ser Ser Ala Ser Ser Thr Glu
     130                 135                 140                
 Asn Ser Val Lys Thr Pro Ala Ser Pro Thr Arg Pro Ser Gln Cys Gln
 145                 150                 155                 160
 Gly Ser Leu Pro Ser Ser Thr Cys Phe Leu Leu Leu Pro Leu Leu Lys
                 165                 170                 175    
 Val Pro Leu Leu Leu Ser Ile Leu Gly Ala Ile Leu Trp Val Asn Arg
             180                 185                 190        
 Pro Trp Arg Thr Pro Trp Thr Glu Ser
         195                 200    



      <210> 1055
      <211> 371
      <212> PRT
      <213> Homo sapiens


      <400> 1055
 Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala
   1               5                  10                  15    
 Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe
              20                  25                  30        
 Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala
          35                  40                  45            
 Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala
      50                  55                  60                
 Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly
  65                  70                  75                  80
 Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln
                  85                  90                  95    
 Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser
             100                 105                 110        
 Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly
         115                 120                 125            
 Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly
     130                 135                 140                
 Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala
 145                 150                 155                 160
 Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala Arg Glu
                 165                 170                 175    
 Ala Glu Gln Gln Arg Ala Tyr Leu Glu Gly Arg Cys Val Glu Trp Leu
             180                 185                 190        
 Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro
         195                 200                 205            
 Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr
     210                 215                 220                
 Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr
 225                 230                 235                 240
 Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu
                 245                 250                 255    
 Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val
             260                 265                 270        
 Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu
         275                 280                 285            
 Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro
     290                 295                 300                
 Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala
 305                 310                 315                 320
 Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser
                 325                 330                 335    
 Ser Gly Gly Glu Gly Val Lys Asp Arg Lys Gly Gly Ser Tyr Thr Gln
             340                 345                 350        
 Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu Thr Ala
         355                 360                 365            
 Cys Lys Val
     370    



      <210> 1056
      <211> 150
      <212> PRT
      <213> Homo sapiens


      <400> 1056
 Lys Leu Ala Asp Ala Gly Glu Ala Leu Thr Phe Pro Glu Gly Tyr Ala
   1               5                  10                  15    
 Lys Gly Ser Ser Gln Leu Leu Leu Pro Ala Thr Phe Leu Ser Ala Glu
              20                  25                  30        
 Leu Ala Leu Leu Gln Lys Ser Phe His Val Asn Ile Gln Asp Thr Met
          35                  40                  45            
 Ile Gly Glu Leu Pro Pro Gln Thr Thr Lys Thr Leu Ala Arg Phe Ile
      50                  55                  60                
 Pro Glu Val Ala Val Ala Tyr Pro Lys Ser Lys Pro Leu Thr Thr Gln
  65                  70                  75                  80
 Ile Lys Ile Lys Lys Pro Pro Lys Val Thr Met Lys Thr Gly Lys Ser
                  85                  90                  95    
 Leu Leu His Leu His Ser Thr Leu Glu Met Phe Ala Ala Arg Trp Arg
             100                 105                 110        
 Ser Lys Ala Pro Met Ser Leu Phe Leu Leu Glu Val His Phe Asn Leu
         115                 120                 125            
 Lys Val Gln Tyr Ser Val His Glu Asn Gln Leu Gln Met Ala Thr Ser
     130                 135                 140                
 Leu Asp Arg Arg Gly Asn
 145                 150



      <210> 1057
      <211> 454
      <212> PRT
      <213> Homo sapiens


      <400> 1057
 Met Leu Arg Ile Leu Cys Leu Ala Leu Cys Ser Leu Leu Thr Gly Thr
   1               5                  10                  15    
 Arg Ala Asp Pro Gly Ala Leu Leu Arg Leu Gly Met Asp Ile Met Asn
              20                  25                  30        
 Arg Glu Val Gln Ser Ala Met Asp Glu Ser His Ile Leu Glu Lys Met
          35                  40                  45            
 Ala Ala Glu Ala Gly Lys Lys Gln Pro Gly Met Lys Pro Ile Lys Gly
      50                  55                  60                
 Ile Thr Asn Leu Lys Val Lys Asp Val Gln Leu Pro Val Ile Thr Leu
  65                  70                  75                  80
 Asn Phe Val Pro Gly Val Gly Ile Phe Gln Cys Val Ser Thr Gly Met
                  85                  90                  95    
 Thr Val Thr Gly Lys Ser Phe Met Gly Gly Asn Met Glu Ile Ile Val
             100                 105                 110        
 Ala Leu Asn Ile Thr Ala Thr Asn Arg Leu Leu Arg Asp Glu Glu Thr
         115                 120                 125            
 Gly Leu Pro Val Phe Lys Ser Glu Gly Cys Glu Val Ile Leu Val Asn
     130                 135                 140                
 Val Lys Thr Asn Leu Pro Ser Asn Met Leu Pro Lys Met Val Asn Lys
 145                 150                 155                 160
 Phe Leu Asp Ser Thr Leu His Lys Val Leu Pro Gly Leu Met Cys Pro
                 165                 170                 175    
 Ala Ile Asp Ala Val Leu Val Tyr Val Asn Arg Lys Trp Thr Asn Leu
             180                 185                 190        
 Ser Asp Pro Met Pro Val Gly Gln Met Gly Thr Val Lys Tyr Val Leu
         195                 200                 205            
 Met Ser Ala Pro Ala Thr Thr Ala Ser Tyr Ile Gln Leu Asp Phe Ser
     210                 215                 220                
 Pro Val Val Gln Gln Gln Lys Gly Lys Thr Ile Lys Leu Ala Asp Ala
 225                 230                 235                 240
 Gly Glu Ala Leu Thr Phe Pro Glu Gly Tyr Ala Lys Gly Ser Ser Gln
                 245                 250                 255    
 Leu Leu Leu Pro Ala Thr Phe Leu Ser Ala Glu Leu Ala Leu Leu Gln
             260                 265                 270        
 Lys Ser Phe His Val Asn Ile Gln Asp Thr Met Ile Gly Glu Leu Pro
         275                 280                 285            
 Pro Gln Thr Thr Lys Thr Leu Ala Arg Phe Ile Pro Glu Val Ala Val
     290                 295                 300                
 Ala Tyr Pro Lys Ser Lys Pro Leu Thr Thr Gln Ile Lys Ile Lys Lys
 305                 310                 315                 320
 Pro Pro Lys Val Thr Met Lys Thr Gly Lys Ser Leu Leu His Leu His
                 325                 330                 335    
 Ser Thr Leu Glu Met Phe Ala Ala Arg Trp Arg Ser Lys Ala Pro Met
             340                 345                 350        
 Ser Leu Phe Leu Leu Glu Val His Phe Asn Leu Lys Val Gln Tyr Ser
         355                 360                 365            
 Val His Glu Asn Gln Leu Gln Met Ala Thr Ser Leu Asp Arg Leu Leu
     370                 375                 380                
 Ser Leu Ser Arg Lys Ser Ser Ser Ile Gly Asn Phe Asn Glu Arg Glu
 385                 390                 395                 400
 Leu Thr Gly Phe Ile Thr Ser Tyr Leu Glu Glu Ala Tyr Ile Pro Val
                 405                 410                 415    
 Val Asn Asp Val Leu Gln Val Gly Leu Pro Leu Pro Asp Phe Leu Ala
             420                 425                 430        
 Met Asn Tyr Asn Leu Ala Glu Leu Asp Ile Val Glu Leu Gly Gly Ile
         435                 440                 445            
 Met Glu Pro Ala Asp Ile
     450                



      <210> 1058
      <211> 385
      <212> PRT
      <213> Homo sapiens


      <400> 1058
 Met Leu Arg Ile Leu Cys Leu Ala Leu Cys Ser Leu Leu Thr Gly Thr
   1               5                  10                  15    
 Arg Ala Asp Pro Gly Ala Leu Leu Arg Leu Gly Met Asp Ile Met Asn
              20                  25                  30        
 Arg Glu Val Gln Ser Ala Met Asp Glu Ser His Ile Leu Glu Lys Met
          35                  40                  45            
 Ala Ala Glu Ala Gly Lys Lys Gln Pro Gly Met Lys Pro Ile Lys Gly
      50                  55                  60                
 Ile Thr Asn Leu Lys Val Lys Asp Val Gln Leu Pro Val Ile Thr Leu
  65                  70                  75                  80
 Asn Phe Val Pro Gly Val Gly Ile Phe Gln Cys Val Ser Thr Gly Met
                  85                  90                  95    
 Thr Val Thr Gly Lys Ser Phe Met Gly Gly Asn Met Glu Ile Ile Val
             100                 105                 110        
 Ala Leu Asn Ile Thr Ala Thr Asn Arg Leu Leu Arg Asp Glu Glu Thr
         115                 120                 125            
 Gly Leu Pro Val Phe Lys Ser Glu Gly Cys Glu Val Ile Leu Val Asn
     130                 135                 140                
 Val Lys Thr Asn Leu Pro Ser Asn Met Leu Pro Lys Met Val Asn Lys
 145                 150                 155                 160
 Phe Leu Asp Ser Thr Leu His Lys Val Leu Pro Gly Leu Met Cys Pro
                 165                 170                 175    
 Ala Ile Asp Ala Val Leu Val Tyr Val Asn Arg Lys Trp Thr Asn Leu
             180                 185                 190        
 Ser Asp Pro Met Pro Val Gly Gln Met Gly Thr Val Lys Tyr Val Leu
         195                 200                 205            
 Met Ser Ala Pro Ala Thr Thr Ala Ser Tyr Ile Gln Leu Asp Phe Ser
     210                 215                 220                
 Pro Val Val Gln Gln Gln Lys Gly Lys Thr Ile Lys Leu Ala Asp Ala
 225                 230                 235                 240
 Gly Glu Ala Leu Thr Phe Pro Glu Gly Tyr Ala Lys Gly Ser Ser Gln
                 245                 250                 255    
 Leu Leu Leu Pro Ala Thr Phe Leu Ser Ala Glu Leu Ala Leu Leu Gln
             260                 265                 270        
 Lys Ser Phe His Val Asn Ile Gln Asp Thr Met Ile Gly Glu Leu Pro
         275                 280                 285            
 Pro Gln Thr Thr Lys Thr Leu Ala Arg Phe Ile Pro Glu Val Ala Val
     290                 295                 300                
 Ala Tyr Pro Lys Ser Lys Pro Leu Thr Thr Gln Ile Lys Ile Lys Lys
 305                 310                 315                 320
 Pro Pro Lys Val Thr Met Lys Thr Gly Lys Ser Leu Leu His Leu His
                 325                 330                 335    
 Ser Thr Leu Glu Met Phe Ala Ala Arg Trp Arg Ser Lys Ala Pro Met
             340                 345                 350        
 Ser Leu Phe Leu Leu Glu Val His Phe Asn Leu Lys Val Gln Tyr Ser
         355                 360                 365            
 Val His Glu Asn Gln Leu Gln Met Ala Thr Ser Leu Asp Arg Arg Gly
     370                 375                 380                
 Asn
 385



      <210> 1059
      <211> 401
      <212> PRT
      <213> Homo sapiens


      <400> 1059
 Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr
   1               5                  10                  15    
 Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp
              20                  25                  30        
 Pro Thr Leu Asp Pro Gly Ala Leu Leu Arg Leu Gly Met Asp Ile Met
          35                  40                  45            
 Asn Gln Val Gln Ser Ala Met Asp Glu Ser His Ile Leu Glu Lys Met
      50                  55                  60                
 Ala Ala Glu Ala Gly Lys Lys Gln Pro Gly Met Lys Pro Ile Lys Gly
  65                  70                  75                  80
 Ile Thr Asn Leu Lys Val Lys Asp Val Gln Leu Pro Val Ile Thr Leu
                  85                  90                  95    
 Asn Phe Val Pro Gly Val Gly Ile Phe Gln Cys Val Ser Thr Gly Met
             100                 105                 110        
 Thr Val Thr Gly Lys Ser Phe Met Gly Gly Asn Met Glu Ile Ile Val
         115                 120                 125            
 Ala Leu Asn Ile Thr Ala Thr Asn Arg Leu Leu Arg Asp Glu Glu Thr
     130                 135                 140                
 Gly Leu Pro Val Phe Lys Ser Glu Gly Cys Glu Val Ile Leu Val Asn
 145                 150                 155                 160
 Val Lys Thr Asn Leu Pro Ser Asn Met Leu Pro Lys Met Val Asn Lys
                 165                 170                 175    
 Phe Leu Asp Ser Thr Leu His Lys Val Leu Pro Gly Leu Met Cys Pro
             180                 185                 190        
 Ala Ile Asp Ala Val Leu Val Tyr Val Asn Arg Lys Trp Thr Asn Leu
         195                 200                 205            
 Ser Asp Pro Met Pro Val Gly Gln Met Gly Thr Val Lys Tyr Val Leu
     210                 215                 220                
 Met Ser Ala Pro Ala Thr Thr Ala Ser Tyr Ile Gln Leu Asp Phe Ser
 225                 230                 235                 240
 Pro Val Val Gln Gln Gln Lys Gly Lys Thr Ile Lys Leu Ala Asp Ala
                 245                 250                 255    
 Gly Glu Ala Leu Thr Phe Pro Glu Gly Tyr Ala Lys Gly Ser Ser Gln
             260                 265                 270        
 Leu Leu Leu Pro Ala Thr Phe Leu Ser Ala Glu Leu Ala Leu Leu Gln
         275                 280                 285            
 Lys Ser Phe His Val Asn Ile Gln Asp Thr Met Ile Gly Glu Leu Pro
     290                 295                 300                
 Pro Gln Thr Thr Lys Thr Leu Ala Arg Phe Ile Pro Glu Val Ala Val
 305                 310                 315                 320
 Ala Tyr Pro Lys Ser Lys Pro Leu Thr Thr Gln Ile Lys Ile Lys Lys
                 325                 330                 335    
 Pro Pro Lys Val Thr Met Lys Thr Gly Lys Ser Leu Leu His Leu His
             340                 345                 350        
 Ser Thr Leu Glu Met Phe Ala Ala Arg Trp Arg Ser Lys Ala Pro Met
         355                 360                 365            
 Ser Leu Phe Leu Leu Glu Val His Phe Asn Leu Lys Val Gln Tyr Ser
     370                 375                 380                
 Val His Glu Asn Gln Leu Gln Met Ala Thr Ser Leu Asp Arg Arg Gly
 385                 390                 395                 400
 Asn
    



      <210> 1060
      <211> 211
      <212> PRT
      <213> Homo sapiens


      <400> 1060
 Met Val Ser Arg Met Val Ser Thr Met Leu Ser Gly Leu Leu Phe Trp
   1               5                  10                  15    
 Leu Ala Ser Gly Trp Thr Pro Ala Phe Ala Tyr Ser Pro Arg Thr Pro
              20                  25                  30        
 Asp Arg Val Ser Glu Ala Asp Ile Gln Arg Leu Leu His Gly Val Met
          35                  40                  45            
 Glu Gln Leu Gly Ile Ala Arg Pro Arg Val Glu Tyr Pro Ala His Gln
      50                  55                  60                
 Ala Met Asn Leu Val Gly Pro Gln Ser Ile Glu Gly Gly Ala His Glu
  65                  70                  75                  80
 Gly Leu Gln His Leu Gly Pro Phe Gly Asn Ile Pro Asn Ile Val Ala
                  85                  90                  95    
 Glu Leu Thr Gly Asp Asn Ile Pro Lys Asp Phe Ser Glu Asp Gln Gly
             100                 105                 110        
 Tyr Pro Asp Pro Pro Asn Pro Cys Pro Val Gly Lys Thr Asp Asp Gly
         115                 120                 125            
 Cys Leu Glu Asn Thr Pro Asp Thr Ala Glu Phe Ser Arg Glu Phe Gln
     130                 135                 140                
 Leu His Gln His Leu Phe Asp Pro Glu His Asp Tyr Pro Gly Leu Gly
 145                 150                 155                 160
 Lys Trp Asn Lys Lys Leu Leu Tyr Glu Lys Met Lys Gly Gly Glu Arg
                 165                 170                 175    
 Arg Lys Arg Arg Ser Val Asn Pro Tyr Leu Gln Gly Gln Arg Leu Asp
             180                 185                 190        
 Asn Val Val Ala Lys Lys Ser Val Pro His Phe Ser Asp Glu Asp Lys
         195                 200                 205            
 Asp Pro Glu
     210    



      <210> 1061
      <211> 454
      <212> PRT
      <213> Homo sapiens


      <400> 1061
 Met Ala Glu Phe Ser Gln Lys Arg Gly Lys Arg Arg Ser Asp Glu Gly
   1               5                  10                  15    
 Leu Gly Ser Met Val Asp Phe Leu Leu Ala Asn Ala Arg Leu Val Leu
              20                  25                  30        
 Gly Val Gly Gly Ala Ala Val Leu Gly Ile Ala Thr Leu Ala Val Lys
          35                  40                  45            
 Arg Phe Ile Asp Arg Ala Thr Ser Pro Arg Asp Glu Asp Asp Thr Lys
      50                  55                  60                
 Ala Asp Ser Trp Lys Glu Leu Ser Leu Leu Lys Ala Thr Pro His Leu
  65                  70                  75                  80
 Gln Pro Arg Pro Pro Pro Ala Ala Leu Ser Gln Pro Val Leu Pro Leu
                  85                  90                  95    
 Ala Pro Ser Ser Ser Ala Pro Glu Gly Pro Ala Glu Thr Asp Pro Glu
             100                 105                 110        
 Val Thr Pro Gln Leu Ser Ser Pro Ala Pro Leu Cys Leu Thr Leu Gln
         115                 120                 125            
 Glu Arg Leu Leu Ala Phe Glu Arg Asp Arg Val Thr Ile Pro Ala Ala
     130                 135                 140                
 Gln Val Ala Leu Ala Lys Gln Leu Ala Gly Asp Ile Ala Leu Glu Leu
 145                 150                 155                 160
 Gln Ala Tyr Phe Arg Ser Lys Phe Pro Glu Leu Pro Phe Gly Ala Phe
                 165                 170                 175    
 Val Pro Gly Gly Pro Leu Tyr Asp Gly Leu Gln Ala Gly Ala Ala Asp
             180                 185                 190        
 His Val Arg Leu Leu Val Pro Leu Val Leu Glu Pro Gly Leu Trp Ser
         195                 200                 205            
 Leu Val Pro Gly Val Asp Thr Val Ala Arg Asp Pro Arg Cys Trp Ala
     210                 215                 220                
 Val Arg Arg Thr Gln Leu Glu Phe Cys Pro Arg Gly Ser Ser Pro Trp
 225                 230                 235                 240
 Asp Arg Phe Leu Val Gly Gly Tyr Leu Ser Ser Arg Val Leu Leu Glu
                 245                 250                 255    
 Leu Leu Arg Lys Ala Leu Ala Ala Ser Val Asn Trp Pro Ala Ile Gly
             260                 265                 270        
 Ser Leu Leu Gly Cys Leu Ile Arg Pro Ser Met Ala Ser Glu Glu Leu
         275                 280                 285            
 Leu Leu Glu Val Gln His Glu Arg Leu Glu Leu Thr Val Ala Val Leu
     290                 295                 300                
 Val Ala Val Pro Gly Val Asp Ala Asp Asp Arg Leu Leu Leu Ala Trp
 305                 310                 315                 320
 Pro Leu Glu Gly Leu Ala Gly Asn Leu Trp Leu Gln Asp Leu Tyr Pro
                 325                 330                 335    
 Val Glu Ala Ala Arg Leu Arg Ala Leu Asp Asp His Asp Ala Gly Thr
             340                 345                 350        
 Arg Arg Arg Leu Leu Leu Leu Leu Cys Ala Val Cys Arg Gly Cys Ser
         355                 360                 365            
 Ala Leu Gly Gln Leu Gly Arg Gly His Leu Thr Gln Val Val Leu Arg
     370                 375                 380                
 Leu Gly Glu Asp Asn Val Asp Trp Thr Glu Glu Ala Leu Gly Glu Arg
 385                 390                 395                 400
 Phe Leu Gln Ala Leu Glu Leu Leu Ile Gly Ser Leu Glu Gln Ala Ser
                 405                 410                 415    
 Leu Pro Cys His Phe Asn Pro Ser Val Asn Leu Phe Ser Ser Leu Arg
             420                 425                 430        
 Glu Glu Glu Ile Asp Asp Ile Gly Tyr Ala Leu Tyr Ser Gly Leu Gln
         435                 440                 445            
 Glu Pro Glu Gly Leu Leu
     450                



      <210> 1062
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 1062
 Met Ala Ser Thr Gly Leu Glu Leu Leu Gly Met Thr Leu Ala Val Leu
   1               5                  10                  15    
 Gly Trp Leu Gly Thr Leu Val Ser Cys Ala Leu Pro Leu Trp Lys Val
              20                  25                  30        
 Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu
          35                  40                  45            
 Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys
      50                  55                  60                
 Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala
  65                  70                  75                  80
 Arg Ala Leu Cys Val Ile Ala Leu Leu Leu Ala Leu Leu Gly Leu Leu
                  85                  90                  95    
 Val Ala Ile Thr Gly Ala Gln Cys Thr Thr Cys Val Glu Asp Glu Gly
             100                 105                 110        
 Ala Lys Ala Arg Ile Val Leu Thr Ala Gly Val Ile Leu Leu Leu Ala
         115                 120                 125            
 Gly Ile Leu Val Leu Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile
     130                 135                 140                
 Gln Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Leu Lys Arg Glu Leu
 145                 150                 155                 160
 Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ala Ala Leu Leu Met Leu
                 165                 170                 175    
 Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Pro Pro Gln Val Glu Arg
             180                 185                 190        
 Pro Arg Gly Pro Arg Leu Gly Tyr Ser Ile Pro Ser Arg Ser Gly Ala
         195                 200                 205            
 Ser Gly Leu Asp Lys Arg Asp Tyr Val
     210                 215        



      <210> 1063
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 1063
 Met Ala Ser Arg Asn Pro Ser Pro Arg Val Ser His Phe Gly Phe Phe
   1               5                  10                  15    
 Lys Lys Lys Phe Lys Lys Glu Arg Lys Lys Glu Arg Lys Lys Ser Gln
              20                  25                  30        
 Ser Gln Arg Tyr Asp Phe Leu Lys Trp Val Asn Pro Lys Phe Leu Arg
          35                  40                  45            
 Asn Met His Phe Ala Lys Lys Tyr Lys Lys Lys Cys Met Lys Lys Met
      50                  55                  60                
 Gln Ala Asn Thr Thr Lys Ala Leu Ser Ala His Ala Glu Ala Ile Lys
  65                  70                  75                  80
 Thr Leu Val Lys Ser Lys Glu Val Lys Pro Lys Ile Ser Lys Gly Val
                  85                  90                  95    
 Gly Ser Lys Ile His Arg Leu Ala Tyr Ile Ala His Ser Lys Leu Gly
             100                 105                 110        
 Thr His Ala His Ala Arg Thr Ala Lys Gly Leu Arg Leu Cys Trp Pro
         115                 120                 125            
 Lys Ala Lys Asn Gln Thr Lys Ala Gln Thr Ala Ala Pro Ala Ser Val
     130                 135                 140                
 Pro Ala Gln Ala Leu Lys Ser Ala His Ala Pro Lys Arg Leu Gln Ser
 145                 150                 155                 160
 Arg Asp Leu His Leu Gln Thr
                 165        



      <210> 1064
      <211> 796
      <212> PRT
      <213> Homo sapiens


      <400> 1064
 Met Val Glu Ile Val Lys Thr Pro Gly Ser Ala Leu Gly Ile Ser Leu
   1               5                  10                  15    
 Thr Thr Thr Ser Leu Arg Asn Lys Ser Val Ile Thr Ile Asp Arg Ile
              20                  25                  30        
 Lys Pro Ala Ser Val Val Asp Arg Ser Gly Ala Leu His Pro Gly Asp
          35                  40                  45            
 His Ile Leu Ser Ile Asp Gly Thr Ser Met Glu His Cys Ser Leu Leu
      50                  55                  60                
 Glu Ala Thr Lys Leu Leu Ala Ser Ile Ser Glu Lys Val Arg Leu Glu
  65                  70                  75                  80
 Ile Leu Pro Val Pro Gln Ser Gln Arg Pro Leu Arg Pro Ser Glu Ala
                  85                  90                  95    
 Val Lys Val Gln Arg Ser Glu Gln Leu His Arg Trp Asp Pro Cys Val
             100                 105                 110        
 Pro Ser Cys His Ser Pro Arg Pro Gly His Cys Arg Met Pro Thr Trp
         115                 120                 125            
 Ala Thr Pro Ala Gly Gln Asp Gln Ser Arg Ser Leu Ser Ser Thr Pro
     130                 135                 140                
 Phe Ser Ser Pro Thr Leu Asn His Ala Phe Ser Cys Asn Asn Pro Ser
 145                 150                 155                 160
 Thr Leu Pro Arg Gly Ser Gln Pro Met Ser Pro Arg Thr Thr Met Gly
                 165                 170                 175    
 Arg Arg Arg Gln Arg Arg Arg Glu His Lys Ser Ser Leu Ser Leu Ala
             180                 185                 190        
 Ser Ser Thr Val Gly Pro Gly Gly Gln Ile Val His Thr Glu Thr Thr
         195                 200                 205            
 Glu Val Val Leu Cys Gly Asp Pro Leu Ser Gly Phe Gly Leu Gln Leu
     210                 215                 220                
 Gln Gly Gly Ile Phe Ala Thr Glu Thr Leu Ser Ser Pro Pro Leu Val
 225                 230                 235                 240
 Cys Phe Ile Glu Pro Asp Ser Pro Ala Glu Arg Cys Gly Leu Leu Gln
                 245                 250                 255    
 Val Gly Asp Arg Val Leu Ser Ile Asn Gly Ile Ala Thr Glu Asp Gly
             260                 265                 270        
 Thr Met Glu Glu Ala Asn Gln Leu Leu Arg Asp Ala Ala Leu Ala His
         275                 280                 285            
 Lys Val Val Leu Glu Val Glu Phe Asp Val Ala Glu Ser Val Ile Pro
     290                 295                 300                
 Ser Ser Gly Thr Phe His Val Lys Leu Pro Lys Lys Arg Ser Val Glu
 305                 310                 315                 320
 Leu Gly Ile Thr Ile Ser Ser Ala Ser Arg Lys Arg Gly Glu Pro Leu
                 325                 330                 335    
 Ile Ile Ser Asp Ile Lys Lys Gly Ser Val Ala His Arg Thr Gly Thr
             340                 345                 350        
 Leu Glu Pro Gly Asp Lys Leu Leu Ala Ile Asp Asn Ile Arg Leu Asp
         355                 360                 365            
 Asn Cys Pro Met Glu Asp Ala Val Gln Ile Leu Arg Gln Cys Glu Asp
     370                 375                 380                
 Leu Val Lys Leu Lys Ile Arg Lys Asp Glu Asp Asn Ser Asp Glu Leu
 385                 390                 395                 400
 Glu Thr Thr Gly Ala Val Ser Tyr Thr Val Glu Leu Lys Arg Tyr Gly
                 405                 410                 415    
 Gly Pro Leu Gly Ile Thr Ile Ser Gly Thr Glu Glu Pro Phe Asp Pro
             420                 425                 430        
 Ile Val Ile Ser Gly Leu Thr Lys Arg Gly Leu Ala Glu Arg Thr Gly
         435                 440                 445            
 Ala Ile His Val Gly Asp Arg Ile Leu Ala Ile Asn Asn Val Ser Leu
     450                 455                 460                
 Lys Gly Arg Pro Leu Ser Glu Ala Ile His Leu Leu Gln Val Ala Gly
 465                 470                 475                 480
 Glu Thr Val Thr Leu Lys Ile Lys Lys Gln Leu Asp Arg Pro Leu Leu
                 485                 490                 495    
 Pro Arg Lys Ser Gly Ser Leu Ser Glu Thr Ser Asp Ala Asp Glu Asp
             500                 505                 510        
 Pro Ala Asp Ala Leu Lys Gly Gly Leu Pro Ala Ala Arg Phe Ser Pro
         515                 520                 525            
 Ala Val Pro Ser Val Asp Ser Ala Val Glu Ser Trp Asp Ser Ser Ala
     530                 535                 540                
 Thr Glu Gly Gly Phe Gly Gly Pro Gly Ser Tyr Thr Pro Gln Ala Ala
 545                 550                 555                 560
 Ala Arg Gly Thr Thr Pro Gln Glu Arg Arg Pro Gly Trp Leu Arg Gly
                 565                 570                 575    
 Ser Pro Pro Pro Thr Glu Pro Arg Arg Thr Ser Tyr Thr Pro Thr Pro
             580                 585                 590        
 Ala Asp Glu Ser Phe Pro Glu Glu Glu Glu Gly Asp Asp Trp Glu Pro
         595                 600                 605            
 Pro Thr Ser Pro Ala Pro Gly Pro Ala Arg Glu Glu Gly Phe Trp Arg
     610                 615                 620                
 Met Phe Gly Glu Ala Leu Glu Asp Leu Glu Ser Cys Gly Gln Ser Glu
 625                 630                 635                 640
 Leu Leu Arg Glu Leu Glu Ala Ser Ile Met Thr Gly Thr Val Gln Arg
                 645                 650                 655    
 Val Ala Leu Glu Gly Arg Pro Gly His Arg Pro Trp Gln Arg Gly Arg
             660                 665                 670        
 Glu Val Arg Ala Ser Pro Ala Glu Met Glu Glu Leu Leu Leu Pro Thr
         675                 680                 685            
 Pro Leu Glu Met His Lys Val Thr Leu His Lys Asp Pro Met Arg His
     690                 695                 700                
 Asp Phe Gly Phe Ser Val Ser Asp Gly Leu Leu Glu Lys Gly Val Tyr
 705                 710                 715                 720
 Val His Thr Val Arg Pro Asp Gly Pro Ala His Arg Gly Gly Leu Gln
                 725                 730                 735    
 Pro Phe Asp Arg Val Leu Gln Val Asn His Val Arg Thr Arg Asp Phe
             740                 745                 750        
 Asp Cys Cys Leu Ala Val Pro Leu Leu Ala Glu Ala Gly Asp Val Leu
         755                 760                 765            
 Glu Leu Ile Ile Ser Arg Lys Pro His Thr Ala His Ser Ser Arg Ala
     770                 775                 780                
 Pro Arg Ser Pro Gly Pro Ser Ser Pro Arg Met Leu
 785                 790                 795    



      <210> 1065
      <211> 554
      <212> PRT
      <213> Homo sapiens


      <400> 1065
 Met Ser Thr Glu Thr Glu Leu Gln Val Ala Val Lys Thr Ser Ala Lys
   1               5                  10                  15    
 Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu Ala Thr Leu Ile
              20                  25                  30        
 Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala Lys Leu Ile Gly
          35                  40                  45            
 Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu Cys Gln Asp Ser
      50                  55                  60                
 Met Met Lys Leu Lys Gly Val Val Ala Gly Ala Arg Ser Lys Gly Glu
  65                  70                  75                  80
 His Lys Gln Lys Ile Phe Leu Thr Ile Ser Phe Gly Gly Ile Lys Ile
                  85                  90                  95    
 Phe Asp Glu Lys Thr Gly Ala Leu Gln His His His Ala Val His Glu
             100                 105                 110        
 Ile Ser Tyr Ile Ala Lys Asp Ile Thr Asp His Arg Ala Phe Gly Tyr
         115                 120                 125            
 Val Cys Gly Lys Glu Gly Asn His Arg Phe Val Ala Ile Lys Thr Ala
     130                 135                 140                
 Gln Ala Ala Glu Pro Val Ile Leu Asp Leu Arg Asp Leu Phe Gln Leu
 145                 150                 155                 160
 Ile Tyr Glu Leu Lys Gln Arg Glu Glu Leu Glu Lys Lys Ala Gln Lys
                 165                 170                 175    
 Asp Lys Gln Cys Glu Gln Ala Val Tyr Gln Thr Ile Leu Glu Glu Asp
             180                 185                 190        
 Val Glu Asp Pro Val Tyr Gln Tyr Ile Val Phe Glu Ala Gly His Glu
         195                 200                 205            
 Pro Ile Arg Asp Pro Glu Thr Glu Glu Asn Ile Tyr Gln Val Pro Thr
     210                 215                 220                
 Ser Gln Lys Lys Glu Gly Val Tyr Asp Val Pro Lys Ser Gln Pro Val
 225                 230                 235                 240
 Ser Ala Val Thr Gln Leu Glu Leu Phe Gly Asp Met Ser Thr Pro Pro
                 245                 250                 255    
 Asp Ile Thr Ser Pro Pro Thr Pro Ala Thr Pro Gly Asp Ala Phe Ile
             260                 265                 270        
 Pro Ser Ser Ser Gln Thr Leu Pro Ala Ser Ala Asp Val Phe Ser Ser
         275                 280                 285            
 Val Pro Phe Gly Thr Ala Ala Val Pro Ser Gly Tyr Val Ala Met Gly
     290                 295                 300                
 Ala Val Leu Pro Ser Phe Trp Gly Gln Gln Pro Leu Val Gln Gln Gln
 305                 310                 315                 320
 Met Val Met Gly Ala Gln Pro Pro Val Ala Gln Val Met Pro Gly Ala
                 325                 330                 335    
 Gln Pro Ile Ala Trp Gly Gln Pro Gly Leu Phe Pro Ala Thr Gln Gln
             340                 345                 350        
 Pro Trp Pro Thr Val Ala Gly Gln Phe Pro Pro Ala Ala Phe Met Pro
         355                 360                 365            
 Thr Gln Thr Val Met Pro Leu Pro Ala Ala Met Phe Gln Gly Pro Leu
     370                 375                 380                
 Thr Pro Leu Ala Thr Val Pro Gly Thr Ser Asp Ser Thr Arg Ser Ser
 385                 390                 395                 400
 Pro Gln Thr Asp Lys Pro Arg Gln Lys Met Gly Lys Glu Thr Phe Lys
                 405                 410                 415    
 Asp Phe Gln Met Ala Gln Pro Pro Pro Val Pro Ser Arg Lys Pro Asp
             420                 425                 430        
 Gln Pro Ser Leu Thr Cys Thr Ser Glu Ala Phe Ser Ser Tyr Phe Asn
         435                 440                 445            
 Lys Val Gly Val Ala Gln Asp Thr Asp Asp Cys Asp Asp Phe Asp Ile
     450                 455                 460                
 Ser Gln Leu Asn Leu Thr Pro Val Thr Ser Thr Thr Pro Ser Thr Asn
 465                 470                 475                 480
 Ser Pro Pro Thr Pro Ala Pro Arg Gln Ser Ser Pro Ser Lys Ser Ser
                 485                 490                 495    
 Ala Ser His Ala Ser Asp Pro Thr Thr Asp Asp Ile Phe Glu Glu Gly
             500                 505                 510        
 Phe Glu Ser Pro Ser Lys Ser Glu Glu Gln Glu Ala Pro Asp Gly Ser
         515                 520                 525            
 Gln Ala Ser Ser Asn Ser Asp Pro Phe Gly Glu Pro Ser Gly Glu Pro
     530                 535                 540                
 Ser Gly Asp Asn Ile Ser Pro Gln Gly Arg
 545                 550                



      <210> 1066
      <211> 326
      <212> PRT
      <213> Homo sapiens


      <400> 1066
 Met Arg Asn Trp Leu Val Leu Leu Cys Pro Cys Val Leu Gly Ala Ala
   1               5                  10                  15    
 Leu His Leu Trp Leu Arg Leu Arg Ser Pro Pro Pro Ala Cys Ala Ser
              20                  25                  30        
 Gly Ala Gly Pro Ala Gly Gly Val Ser Leu Leu Leu Pro Arg Leu Glu
          35                  40                  45            
 Cys Asn Gly Ala Val Ser Ala His Pro Asn Leu His Leu Pro Gly Ser
      50                  55                  60                
 Arg Asp Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Ile Thr Asp Gln
  65                  70                  75                  80
 Leu Ala Leu Phe Pro Gln Trp Lys Ser Thr His Tyr Asp Val Val Val
                  85                  90                  95    
 Gly Val Leu Ser Ala Arg Asn Asn His Glu Leu Arg Asn Val Ile Arg
             100                 105                 110        
 Ser Thr Trp Met Arg His Leu Leu Gln His Pro Thr Leu Ser Gln Arg
         115                 120                 125            
 Val Leu Val Lys Phe Ile Ile Gly Ala His Gly Cys Glu Val Pro Val
     130                 135                 140                
 Glu Asp Arg Glu Asp Pro Tyr Ser Cys Lys Leu Leu Asn Ile Thr Asn
 145                 150                 155                 160
 Pro Val Leu Asn Gln Glu Ile Glu Ala Phe Ser Leu Ser Glu Asp Thr
                 165                 170                 175    
 Ser Ser Gly Leu Pro Glu Asp Arg Val Val Ser Val Ser Phe Arg Val
             180                 185                 190        
 Leu Tyr Pro Ile Val Ile Thr Ser Leu Gly Val Phe Tyr Asp Ala Asn
         195                 200                 205            
 Asp Val Gly Phe Gln Arg Asn Ile Thr Val Lys Leu Tyr Gln Ala Glu
     210                 215                 220                
 Gln Glu Glu Ala Leu Phe Ile Ala Arg Phe Ser Pro Pro Ser Cys Gly
 225                 230                 235                 240
 Val Gln Val Asn Lys Leu Trp Tyr Lys Pro Val Glu Gln Phe Ile Leu
                 245                 250                 255    
 Pro Glu Ser Phe Glu Gly Thr Ile Val Trp Glu Ser Gln Asp Leu His
             260                 265                 270        
 Gly Leu Val Ser Arg Asn Leu His Lys Val Thr Val Asn Asp Gly Gly
         275                 280                 285            
 Gly Val Leu Arg Val Ile Thr Ala Gly Glu Gly Ala Leu Pro His Glu
     290                 295                 300                
 Phe Leu Glu Gly Val Glu Gly Val Ala Gly Gly Phe Ile Tyr Thr Ile
 305                 310                 315                 320
 Gln Gly Lys Phe Ala Ser
                 325    



      <210> 1067
      <211> 358
      <212> PRT
      <213> Homo sapiens


      <400> 1067
 Met Asp Asp Ala Thr Val Leu Arg Lys Lys Gly Tyr Ile Val Gly Ile
   1               5                  10                  15    
 Asn Leu Gly Lys Gly Ser Tyr Ala Lys Val Lys Ser Ala Tyr Ser Glu
              20                  25                  30        
 Arg Leu Lys Phe Asn Val Ala Val Lys Ile Ile Ala Arg Lys Lys Thr
          35                  40                  45            
 Pro Thr Asp Phe Val Glu Arg Phe Leu Pro Arg Glu Met Asp Ile Leu
      50                  55                  60                
 Ala Thr Val Asn His Gly Ser Ile Ile Lys Thr Tyr Glu Ile Phe Glu
  65                  70                  75                  80
 Thr Ser Asp Gly Arg Ile Tyr Ile Ile Met Glu Leu Gly Val Gln Gly
                  85                  90                  95    
 Asp Leu Leu Glu Phe Ile Lys Cys Gln Gly Ala Leu His Glu Asp Val
             100                 105                 110        
 Ala Arg Lys Met Phe Arg Gln Leu Ser Ser Ala Val Lys Tyr Cys His
         115                 120                 125            
 Asp Leu Asp Ile Val His Arg Asp Leu Lys Cys Glu Asn Leu Leu Leu
     130                 135                 140                
 Asp Lys Asp Phe Asn Ile Lys Leu Ser Asp Phe Gly Phe Ser Lys Arg
 145                 150                 155                 160
 Cys Leu Arg Asp Ser Asn Gly Arg Ile Ile Leu Ser Lys Thr Phe Cys
                 165                 170                 175    
 Gly Ser Ala Ala Tyr Ala Ala Pro Glu Val Leu Gln Ser Ile Pro Tyr
             180                 185                 190        
 Gln Pro Lys Val Tyr Asp Ile Trp Ser Leu Gly Val Ile Leu Tyr Ile
         195                 200                 205            
 Met Val Cys Gly Ser Met Pro Tyr Asp Asp Ser Asp Ile Arg Lys Met
     210                 215                 220                
 Leu Arg Ile Gln Lys Glu His Arg Val Asp Phe Pro Arg Ser Lys Asn
 225                 230                 235                 240
 Leu Thr Cys Glu Cys Lys Asp Leu Ile Tyr Arg Met Leu Gln Pro Asp
                 245                 250                 255    
 Val Ser Gln Arg Leu His Ile Asp Glu Ile Leu Ser His Ser Trp Leu
             260                 265                 270        
 Gln Pro Pro Lys Pro Lys Ala Thr Ser Ser Ala Ser Phe Lys Arg Glu
         275                 280                 285            
 Gly Glu Gly Lys Tyr Arg Ala Glu Cys Lys Leu Asp Thr Lys Thr Gly
     290                 295                 300                
 Leu Arg Pro Asp His Arg Pro Asp His Lys Leu Gly Ala Lys Thr Gln
 305                 310                 315                 320
 His Arg Leu Leu Val Val Pro Glu Asn Glu Asn Arg Met Glu Asp Arg
                 325                 330                 335    
 Leu Ala Glu Thr Ser Arg Ala Lys Asp His His Ile Ser Gly Ala Glu
             340                 345                 350        
 Val Gly Lys Ala Ser Thr
         355            



      <210> 1068
      <211> 197
      <212> PRT
      <213> Homo sapiens


      <400> 1068
 Met Ala Thr His His Thr Leu Trp Met Gly Leu Ala Leu Leu Gly Val
   1               5                  10                  15    
 Leu Gly Asp Leu Gln Ala Ala Pro Glu Ala Gln Val Ser Val Gln Pro
              20                  25                  30        
 Asn Phe Gln Gln Asp Lys Phe Leu Gly Arg Trp Phe Ser Ala Gly Leu
          35                  40                  45            
 Ala Ser Asn Ser Ser Trp Leu Arg Glu Lys Lys Ala Ala Leu Ser Met
      50                  55                  60                
 Cys Lys Ser Val Val Ala Pro Ala Thr Asp Gly Gly Leu Asn Leu Thr
  65                  70                  75                  80
 Ser Thr Phe Leu Arg Lys Asn Gln Cys Glu Thr Arg Thr Met Leu Leu
                  85                  90                  95    
 Gln Pro Ala Gly Ser Leu Gly Ser Tyr Ser Tyr Arg Ser Pro His Trp
             100                 105                 110        
 Gly Ser Thr Tyr Ser Val Ser Val Val Glu Thr Asp Tyr Asp Gln Tyr
         115                 120                 125            
 Ala Leu Leu Tyr Ser Gln Gly Ser Lys Gly Pro Gly Glu Asp Phe Arg
     130                 135                 140                
 Met Ala Thr Leu Tyr Ser Arg Thr Gln Thr Pro Arg Ala Glu Leu Lys
 145                 150                 155                 160
 Glu Lys Phe Thr Ala Phe Cys Lys Ala Gln Gly Phe Thr Glu Asp Thr
                 165                 170                 175    
 Ile Val Phe Leu Pro Gln Thr Ala Pro Gly Phe Phe Leu Gly Asp Lys
             180                 185                 190        
 Cys Met Thr Glu Gln
         195        



      <210> 1069
      <211> 273
      <212> PRT
      <213> Homo sapiens


      <400> 1069
 Met Lys Val Lys Val Ile Pro Val Leu Glu Asp Asn Tyr Met Tyr Leu
   1               5                  10                  15    
 Val Ile Glu Glu Leu Thr Arg Glu Ala Val Ala Val Asp Val Ala Val
              20                  25                  30        
 Pro Lys Arg Leu Leu Glu Ile Val Gly Arg Glu Gly Val Ser Leu Thr
          35                  40                  45            
 Ala Val Leu Thr Thr His His His Trp Asp His Ala Arg Gly Asn Pro
      50                  55                  60                
 Glu Leu Ala Arg Leu Arg Pro Gly Leu Ala Val Leu Gly Ala Asp Glu
  65                  70                  75                  80
 Arg Ile Phe Ser Leu Thr Arg Arg Leu Ala His Gly Glu Glu Leu Arg
                  85                  90                  95    
 Phe Gly Ala Ile His Val Arg Cys Leu Leu Thr Pro Gly His Thr Ala
             100                 105                 110        
 Gly His Met Ser Tyr Phe Leu Trp Glu Asp Asp Cys Pro Asp Pro Pro
         115                 120                 125            
 Ala Leu Phe Ser Gly Asp Ala Leu Ser Val Ala Gly Cys Gly Ser Cys
     130                 135                 140                
 Leu Glu Gly Ser Ala Gln Gln Met Tyr Gln Ser Leu Ala Glu Leu Gly
 145                 150                 155                 160
 Thr Leu Pro Pro Glu Thr Lys Val Phe Cys Gly His Glu His Thr Leu
                 165                 170                 175    
 Ser Asn Leu Glu Phe Ala Gln Lys Val Glu Pro Cys Asn Asp His Lys
             180                 185                 190        
 Arg Asp Glu Asp Asp Val Pro Thr Val Pro Ser Thr Leu Gly Glu Glu
         195                 200                 205            
 Arg Leu Tyr Asn Pro Phe Leu Arg Val Ala Glu Glu Pro Val Arg Lys
     210                 215                 220                
 Phe Thr Gly Lys Ala Val Pro Ala Asp Val Leu Glu Ala Leu Cys Lys
 225                 230                 235                 240
 Glu Arg Ala Arg Phe Glu Gln Ala Gly Glu Pro Arg Gln Pro Gln Ala
                 245                 250                 255    
 Arg Ala Leu Leu Ala Leu Gln Trp Gly Leu Leu Ser Ala Ala Pro His
             260                 265                 270        
 Asp
    



      <210> 1070
      <211> 357
      <212> PRT
      <213> Homo sapiens


      <400> 1070
 Met Gly Asn Arg His Ser Gln Ser Tyr Thr Leu Ser Glu Gly Ser Gln
   1               5                  10                  15    
 Gln Leu Pro Lys Gly Asp Ser Gln Pro Ser Thr Val Val Gln Pro Leu
              20                  25                  30        
 Ser His Pro Ser Arg Asn Gly Glu Pro Glu Ala Pro Gln Pro Ala Lys
          35                  40                  45            
 Ala Ser Ser Pro Gln Gly Phe Asp Val Asp Arg Asp Ala Lys Lys Leu
      50                  55                  60                
 Asn Lys Ala Cys Lys Gly Met Gly Thr Asn Glu Ala Ala Ile Ile Glu
  65                  70                  75                  80
 Ile Leu Ser Gly Arg Thr Ser Asp Glu Arg Gln Gln Ile Lys Gln Lys
                  85                  90                  95    
 Tyr Lys Ala Thr Tyr Gly Lys Glu Leu Glu Glu Val Leu Lys Ser Glu
             100                 105                 110        
 Leu Ser Gly Asn Phe Glu Lys Thr Ala Leu Ala Leu Leu Asp His Pro
         115                 120                 125            
 Ser Glu Tyr Ala Ala Arg Gln Leu Gln Lys Ala Met Lys Gly Leu Gly
     130                 135                 140                
 Thr Asp Glu Ser Val Leu Ile Glu Val Leu Cys Thr Arg Thr Asn Lys
 145                 150                 155                 160
 Glu Ile Ile Ala Ile Lys Glu Ala Tyr Gln Arg Leu Phe Asp Arg Ser
                 165                 170                 175    
 Leu Glu Ser Asp Val Lys Gly Asp Thr Ser Gly Asn Leu Lys Lys Ile
             180                 185                 190        
 Leu Val Ser Leu Leu Gln Ala Asn Arg Asn Glu Gly Asp Asp Val Asp
         195                 200                 205            
 Lys Asp Leu Ala Gly Gln Asp Ala Lys Asp Leu Tyr Asp Ala Gly Glu
     210                 215                 220                
 Gly Arg Trp Gly Thr Asp Glu Leu Ala Phe Asn Glu Val Leu Ala Lys
 225                 230                 235                 240
 Arg Ser Tyr Lys Gln Leu Arg Ala Thr Phe Gln Ala Tyr Gln Ile Leu
                 245                 250                 255    
 Ile Gly Lys Asp Ile Glu Glu Ala Ile Glu Glu Glu Thr Ser Gly Asp
             260                 265                 270        
 Leu Gln Lys Ala Tyr Leu Thr Leu Val Arg Cys Ala Gln Asp Cys Glu
         275                 280                 285            
 Asp Tyr Phe Ala Glu Arg Leu Tyr Lys Ser Met Lys Gly Ala Gly Thr
     290                 295                 300                
 Asp Glu Glu Thr Leu Ile Arg Ile Val Val Thr Arg Ala Glu Val Asp
 305                 310                 315                 320
 Leu Gln Gly Ile Lys Ala Lys Phe Gln Glu Lys Tyr Gln Lys Ser Leu
                 325                 330                 335    
 Ser Asp Met Val Arg Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Leu
             340                 345                 350        
 Val Ala Leu Leu His
         355        



      <210> 1071
      <211> 600
      <212> PRT
      <213> Homo sapiens


      <400> 1071
 Met Ala Thr Asn Gly Ser Lys Val Ala Asp Gly Gln Ile Ser Thr Glu
   1               5                  10                  15    
 Val Ser Glu Ala Pro Val Ala Asn Asp Lys Pro Lys Thr Leu Val Val
              20                  25                  30        
 Lys Val Gln Lys Lys Ala Ala Asp Leu Pro Asp Arg Asp Thr Trp Lys
          35                  40                  45            
 Gly Arg Phe Asp Phe Leu Met Ser Cys Val Gly Tyr Ala Ile Gly Leu
      50                  55                  60                
 Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gly Lys Asn Gly Gly Gly
  65                  70                  75                  80
 Ala Phe Leu Ile Pro Tyr Phe Leu Thr Leu Ile Phe Ala Gly Val Pro
                  85                  90                  95    
 Leu Phe Leu Leu Glu Cys Ser Leu Gly Gln Tyr Thr Ser Ile Gly Gly
             100                 105                 110        
 Leu Gly Val Trp Lys Leu Ala Pro Met Phe Lys Gly Val Gly Leu Ala
         115                 120                 125            
 Ala Ala Val Leu Ser Phe Trp Leu Asn Ile Tyr Tyr Ile Val Ile Ile
     130                 135                 140                
 Ser Trp Ala Ile Tyr Tyr Leu Tyr Asn Ser Phe Thr Thr Thr Leu Pro
 145                 150                 155                 160
 Trp Lys Gln Cys Asp Asn Pro Trp Asn Thr Asp Arg Cys Phe Ser Asn
                 165                 170                 175    
 Tyr Ser Met Val Asn Thr Thr Asn Met Thr Ser Ala Val Val Glu Phe
             180                 185                 190        
 Trp Glu Arg Asn Met His Gln Met Thr Asp Gly Leu Asp Lys Pro Gly
         195                 200                 205            
 Gln Ile Arg Trp Pro Leu Ala Ile Thr Leu Ala Ile Ala Trp Ile Leu
     210                 215                 220                
 Val Tyr Phe Cys Ile Trp Lys Gly Val Gly Trp Thr Gly Lys Val Val
 225                 230                 235                 240
 Tyr Phe Ser Ala Thr Tyr Pro Tyr Ile Met Leu Ile Ile Leu Phe Phe
                 245                 250                 255    
 Arg Gly Val Thr Leu Pro Gly Ala Lys Glu Gly Ile Leu Phe Tyr Ile
             260                 265                 270        
 Thr Pro Asn Phe Arg Lys Leu Ser Asp Ser Glu Val Trp Leu Asp Ala
         275                 280                 285            
 Ala Thr Gln Ile Phe Phe Ser Tyr Gly Leu Gly Leu Gly Ser Leu Ile
     290                 295                 300                
 Ala Leu Arg Gly Gly Thr Asn Leu Ser Asn Asn Asn Val Tyr Arg Asp
 305                 310                 315                 320
 Ser Ile Ile Val Cys Cys Ile Asn Ser Arg Thr Ser Met Phe Ala Gly
                 325                 330                 335    
 Phe Val Ile Phe Ser Ile Val Gly Phe Met Ala His Val Thr Lys Arg
             340                 345                 350        
 Ser Ile Ala Asp Val Ala Ala Ser Gly Pro Gly Leu Ala Phe Leu Ala
         355                 360                 365            
 Tyr Pro Glu Ala Val Thr Gln Leu Pro Ile Ser Pro Leu Trp Ala Ile
     370                 375                 380                
 Leu Phe Phe Ser Met Leu Leu Met Leu Gly Ile Asp Ser Gln Phe Cys
 385                 390                 395                 400
 Thr Val Glu Gly Phe Ile Thr Ala Leu Val Asp Glu Tyr Pro Arg Leu
                 405                 410                 415    
 Leu Arg Asn Arg Arg Glu Leu Phe Ile Ala Ala Val Cys Ile Ile Ser
             420                 425                 430        
 Tyr Leu Ile Gly Leu Ser Asn Ile Thr Gln Gly Gly Ile Tyr Val Phe
         435                 440                 445            
 Lys Leu Phe Asp Tyr Tyr Ser Ala Ser Gly Met Ser Leu Leu Phe Leu
     450                 455                 460                
 Val Phe Phe Glu Cys Val Ser Ile Ser Trp Phe Tyr Gly Val Asn Arg
 465                 470                 475                 480
 Phe Tyr Asp Asn Ile Gln Glu Met Val Gly Ser Arg Pro Cys Ile Trp
                 485                 490                 495    
 Trp Lys Leu Cys Trp Ser Phe Phe Thr Pro Ile Ile Val Ala Gly Val
             500                 505                 510        
 Phe Ile Phe Ser Ala Val Gln Met Thr Pro Leu Thr Met Gly Asn Tyr
         515                 520                 525            
 Val Phe Pro Lys Trp Gly Gln Gly Val Gly Trp Leu Met Ala Leu Ser
     530                 535                 540                
 Ser Met Val Leu Ile Pro Gly Tyr Met Ala Tyr Met Phe Leu Thr Leu
 545                 550                 555                 560
 Lys Gly Ser Leu Lys Gln Arg Ile Gln Val Met Val Gln Pro Ser Glu
                 565                 570                 575    
 Asp Ile Val Arg Pro Glu Asn Gly Pro Glu Gln Pro Gln Ala Gly Ser
             580                 585                 590        
 Ser Thr Ser Lys Glu Ala Tyr Ile
         595                 600



      <210> 1072
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 1072
 Met Pro Ala Phe Asn Arg Leu Phe Pro Leu Ala Ser Leu Val Leu Ile
   1               5                  10                  15    
 Tyr Trp Val Ser Val Cys Phe Pro Val Cys Val Glu Val Pro Ser Glu
              20                  25                  30        
 Thr Glu Ala Val Gln Gly Asn Pro Met Lys Leu Arg Cys Ile Ser Cys
          35                  40                  45            
 Met Lys Arg Glu Glu Val Glu Ala Thr Thr Val Val Glu Trp Phe Tyr
      50                  55                  60                
 Arg Pro Glu Gly Gly Lys Asp Phe Leu Ile Tyr Glu Tyr Arg Asn Gly
  65                  70                  75                  80
 His Gln Glu Val Glu Ser Pro Phe Gln Gly Arg Leu Gln Trp Asn Gly
                  85                  90                  95    
 Ser Lys Asp Leu Gln Asp Val Ser Ile Thr Val Leu Asn Val Thr Leu
             100                 105                 110        
 Asn Asp Ser Gly Leu Tyr Thr Cys Asn Val Ser Arg Glu Phe Glu Phe
         115                 120                 125            
 Glu Ala His Arg Pro Phe Val Lys Thr Thr Arg Leu Ile Pro Leu Arg
     130                 135                 140                
 Val Thr Glu Glu Ala Gly Glu Asp Phe Thr Ser Val Val
 145                 150                 155        



      <210> 1073
      <211> 579
      <212> PRT
      <213> Homo sapiens


      <400> 1073
 Met Ser Ala Leu Arg Pro Leu Leu Leu Leu Leu Leu Pro Leu Cys Pro
   1               5                  10                  15    
 Gly Pro Gly Pro Gly Pro Gly Ser Glu Ala Lys Val Thr Arg Ser Cys
              20                  25                  30        
 Ala Glu Thr Arg Gln Val Leu Gly Ala Arg Gly Tyr Ser Leu Asn Leu
          35                  40                  45            
 Ile Pro Pro Ala Leu Ile Ser Gly Glu His Leu Arg Val Cys Pro Gln
      50                  55                  60                
 Glu Tyr Thr Cys Cys Ser Ser Glu Thr Glu Gln Arg Leu Ile Arg Glu
  65                  70                  75                  80
 Thr Glu Ala Thr Phe Arg Gly Leu Val Glu Asp Ser Gly Ser Phe Leu
                  85                  90                  95    
 Val His Thr Leu Ala Ala Arg His Arg Lys Phe Asp Glu Phe Phe Leu
             100                 105                 110        
 Glu Met Leu Ser Val Ala Gln His Ser Leu Thr Gln Leu Phe Ser His
         115                 120                 125            
 Ser Tyr Gly Arg Leu Tyr Ala Gln His Ala Leu Ile Phe Asn Gly Leu
     130                 135                 140                
 Phe Ser Arg Leu Arg Asp Phe Tyr Gly Glu Ser Gly Glu Gly Leu Asp
 145                 150                 155                 160
 Asp Thr Leu Ala Asp Phe Trp Ala Gln Leu Leu Glu Arg Val Phe Pro
                 165                 170                 175    
 Leu Leu His Pro Gln Tyr Ser Phe Pro Pro Asp Tyr Leu Leu Cys Leu
             180                 185                 190        
 Ser Arg Leu Ala Ser Ser Thr Asp Gly Ser Leu Gln Pro Phe Gly Asp
         195                 200                 205            
 Ser Pro Arg Arg Leu Arg Leu Gln Ile Thr Arg Thr Leu Val Ala Ala
     210                 215                 220                
 Arg Ala Phe Val Gln Gly Leu Glu Thr Gly Arg Asn Val Val Ser Glu
 225                 230                 235                 240
 Ala Leu Lys Val Pro Val Ser Glu Gly Cys Ser Gln Ala Leu Met Arg
                 245                 250                 255    
 Leu Ile Gly Cys Pro Leu Cys Arg Gly Val Pro Ser Leu Met Pro Cys
             260                 265                 270        
 Gln Gly Phe Cys Leu Asn Val Val Arg Gly Cys Leu Ser Ser Arg Gly
         275                 280                 285            
 Leu Glu Pro Asp Trp Gly Asn Tyr Leu Asp Gly Leu Leu Ile Leu Ala
     290                 295                 300                
 Asp Lys Leu Gln Gly Pro Phe Ser Phe Glu Leu Thr Ala Glu Ser Ile
 305                 310                 315                 320
 Gly Val Lys Ile Ser Glu Gly Leu Met Tyr Leu Gln Glu Asn Ser Ala
                 325                 330                 335    
 Lys Val Ser Ala Gln Val Phe Gln Glu Cys Gly Pro Pro Asp Pro Val
             340                 345                 350        
 Pro Ala Arg Asn Arg Arg Ala Pro Pro Pro Arg Glu Glu Ala Gly Arg
         355                 360                 365            
 Leu Trp Ser Met Val Thr Glu Glu Glu Arg Pro Thr Thr Ala Ala Gly
     370                 375                 380                
 Thr Asn Leu His Arg Leu Val Trp Glu Leu Arg Glu Arg Leu Ala Arg
 385                 390                 395                 400
 Met Arg Gly Phe Trp Ala Arg Leu Ser Leu Thr Val Cys Gly Asp Ser
                 405                 410                 415    
 Arg Met Ala Ala Asp Ala Ser Leu Glu Ala Ala Pro Cys Trp Thr Gly
             420                 425                 430        
 Ala Gly Arg Gly Arg Tyr Leu Pro Pro Val Val Gly Gly Ser Pro Ala
         435                 440                 445            
 Glu Gln Val Asn Asn Pro Glu Leu Lys Val Asp Ala Ser Gly Pro Asp
     450                 455                 460                
 Val Pro Thr Arg Arg Arg Arg Leu Gln Leu Arg Ala Ala Thr Ala Arg
 465                 470                 475                 480
 Met Lys Thr Ala Ala Leu Gly His Asp Leu Asp Gly Gln Asp Ala Asp
                 485                 490                 495    
 Glu Asp Ala Ser Gly Ser Gly Gly Gly Gln Gln Tyr Ala Asp Asp Trp
             500                 505                 510        
 Met Ala Gly Ala Val Ala Pro Pro Ala Arg Pro Pro Arg Pro Pro Tyr
         515                 520                 525            
 Pro Pro Arg Arg Asp Gly Ser Gly Gly Lys Gly Gly Gly Gly Ser Ala
     530                 535                 540                
 Arg Tyr Asn Gln Gly Arg Ser Arg Ser Gly Gly Ala Ser Ile Gly Phe
 545                 550                 555                 560
 His Thr Gln Thr Ile Leu Ile Leu Ser Leu Ser Ala Leu Ala Leu Leu
                 565                 570                 575    
 Gly Pro Arg
            



      <210> 1074
      <211> 874
      <212> PRT
      <213> Homo sapiens


      <400> 1074
 Met Ala Ala Glu Asp Ser Asp Val Glu Ser Leu Pro Arg Gly Gly Phe
   1               5                  10                  15    
 Arg Cys Cys Leu Cys His Val Thr Thr Ala Asn Arg Pro Ser Leu Asp
              20                  25                  30        
 Ala His Leu Gly Gly Arg Lys His Arg His Leu Val Glu Leu Arg Ala
          35                  40                  45            
 Ala Arg Lys Ala Gln Gly Leu Arg Ser Val Phe Val Ser Gly Phe Pro
      50                  55                  60                
 Arg Asp Leu Asp Ser Ala Gln Leu Ser Glu Tyr Phe Leu Ala Phe Gly
  65                  70                  75                  80
 Pro Val Ala Ser Val Val Met Asp Lys Asp Lys Gly Val Phe Ala Ile
                  85                  90                  95    
 Val Glu Met Gly Asp Val Gly Ala Arg Glu Ala Val Leu Ser Gln Ser
             100                 105                 110        
 Gln His Ser Leu Gly Gly His Arg Leu Arg Val Arg Pro Arg Glu Gln
         115                 120                 125            
 Lys Glu Phe Gln Ser Pro Ala Ser Lys Ser Pro Lys Gly Ala Ala Pro
     130                 135                 140                
 Asp Ser His Gln Leu Ala Lys Ala Leu Ala Glu Ala Ala Asp Val Gly
 145                 150                 155                 160
 Ala Gln Met Ile Lys Leu Val Gly Leu Arg Glu Leu Ser Glu Ala Glu
                 165                 170                 175    
 Arg Gln Leu Arg Ser Leu Val Val Ala Leu Met Gln Glu Val Phe Thr
             180                 185                 190        
 Glu Phe Phe Pro Gly Cys Val Val His Pro Phe Gly Ser Ser Ile Asn
         195                 200                 205            
 Ser Phe Asp Val His Gly Cys Asp Leu Asp Leu Phe Leu Asp Leu Gly
     210                 215                 220                
 Asp Leu Glu Glu Pro Gln Pro Val Pro Lys Ala Pro Glu Ser Pro Ser
 225                 230                 235                 240
 Leu Asp Ser Ala Leu Ala Ser Pro Leu Asp Pro Gln Ala Leu Ala Cys
                 245                 250                 255    
 Thr Pro Ala Ser Pro Pro Asp Ser Gln Pro Pro Ala Ser Pro Gln Asp
             260                 265                 270        
 Ser Glu Ala Leu Asp Phe Glu Thr Pro Ser Ser Ser Leu Ala Pro Gln
         275                 280                 285            
 Thr Pro Asp Ser Ala Leu Ala Ser Glu Thr Leu Ala Ser Pro Gln Ser
     290                 295                 300                
 Leu Pro Pro Ala Ser Pro Leu Leu Glu Asp Arg Glu Glu Gly Asp Leu
 305                 310                 315                 320
 Gly Lys Ala Ser Glu Leu Ala Glu Thr Pro Lys Glu Glu Lys Ala Glu
                 325                 330                 335    
 Gly Ala Ala Met Leu Glu Leu Val Gly Ser Ile Leu Arg Gly Cys Val
             340                 345                 350        
 Pro Gly Val Tyr Arg Val Gln Thr Val Pro Ser Ala Arg Arg Pro Val
         355                 360                 365            
 Val Lys Phe Cys His Arg Pro Ser Gly Leu His Gly Asp Val Ser Leu
     370                 375                 380                
 Ser Asn Arg Leu Ala Leu His Asn Ser Arg Phe Leu Ser Leu Cys Ser
 385                 390                 395                 400
 Glu Leu Asp Gly Arg Val Arg Pro Leu Val Tyr Thr Leu Arg Cys Trp
                 405                 410                 415    
 Ala Gln Gly Arg Gly Leu Ser Gly Ser Gly Pro Leu Leu Ser Asn Tyr
             420                 425                 430        
 Ala Leu Thr Leu Leu Val Ile Tyr Phe Leu Gln Thr Arg Asp Pro Pro
         435                 440                 445            
 Val Leu Pro Thr Val Ser Gln Leu Thr Gln Lys Ala Gly Glu Gly Glu
     450                 455                 460                
 Gln Val Glu Val Asp Gly Trp Asp Cys Ser Phe Pro Arg Asp Ala Ser
 465                 470                 475                 480
 Arg Leu Glu Pro Ser Ile Asn Val Glu Pro Leu Ser Ser Leu Leu Ala
                 485                 490                 495    
 Gln Phe Phe Ser Cys Val Ser Cys Trp Asp Leu Arg Gly Ser Leu Leu
             500                 505                 510        
 Ser Leu Arg Glu Gly Gln Ala Leu Pro Val Ala Gly Gly Leu Pro Ser
         515                 520                 525            
 Asn Leu Trp Glu Gly Leu Arg Leu Gly Pro Leu Asn Leu Gln Asp Pro
     530                 535                 540                
 Phe Asp Leu Ser His Asn Val Ala Ala Asn Val Thr Ser Arg Val Ala
 545                 550                 555                 560
 Gly Arg Leu Gln Asn Cys Cys Arg Ala Ala Ala Asn Tyr Cys Arg Ser
                 565                 570                 575    
 Leu Gln Tyr Gln Arg Arg Ser Ser Arg Gly Arg Asp Trp Gly Leu Leu
             580                 585                 590        
 Pro Leu Leu Gln Pro Ser Ser Pro Ser Ser Leu Leu Ser Ala Thr Pro
         595                 600                 605            
 Ile Pro Leu Pro Leu Ala Pro Phe Thr Gln Leu Thr Ala Ala Leu Val
     610                 615                 620                
 Gln Val Phe Arg Glu Ala Leu Gly Cys His Ile Glu Gln Ala Thr Lys
 625                 630                 635                 640
 Arg Thr Arg Ser Glu Gly Gly Gly Thr Gly Glu Ser Ser Gln Gly Gly
                 645                 650                 655    
 Thr Ser Lys Arg Leu Lys Val Asp Gly Gln Lys Asn Cys Cys Glu Glu
             660                 665                 670        
 Gly Lys Glu Glu Gln Gln Gly Cys Ala Gly Asp Gly Gly Glu Asp Arg
         675                 680                 685            
 Val Glu Glu Met Val Ile Glu Val Gly Glu Met Val Gln Asp Trp Ala
     690                 695                 700                
 Met Gln Ser Pro Gly Gln Pro Gly Asp Leu Pro Leu Thr Thr Gly Lys
 705                 710                 715                 720
 His Gly Ala Pro Gly Glu Glu Gly Gln Pro Ser His Ala Ala Leu Ala
                 725                 730                 735    
 Glu Arg Gly Pro Lys Gly His Glu Ala Ala Gln Glu Trp Ser Gln Gly
             740                 745                 750        
 Glu Ala Gly Lys Gly Ala Ser Leu Pro Ser Ser Ala Ser Trp Arg Cys
         755                 760                 765            
 Ala Leu Trp His Arg Val Trp Gln Gly Arg Arg Arg Ala Arg Arg Arg
     770                 775                 780                
 Leu Gln Gln Gln Thr Lys Glu Gly Ala Gly Gly Gly Ala Gly Thr Arg
 785                 790                 795                 800
 Ala Gly Trp Leu Ala Thr Glu Ala Gln Val Thr Gln Glu Leu Lys Gly
                 805                 810                 815    
 Leu Ser Gly Gly Glu Glu Arg Pro Glu Thr Glu Pro Leu Leu Ser Phe
             820                 825                 830        
 Val Ala Ser Val Ser Pro Ala Asp Arg Met Leu Thr Val Thr Pro Leu
         835                 840                 845            
 Gln Asp Pro Gln Gly Leu Phe Pro Asp Leu His His Phe Leu Gln Val
     850                 855                 860                
 Phe Leu Pro Gln Ala Ile Arg His Leu Lys
 865                 870                



      <210> 1075
      <211> 529
      <212> PRT
      <213> Homo sapiens


      <400> 1075
 Met Lys Pro His Leu Lys Gln Trp Arg Gln Arg Met Leu Phe Gly Ile
   1               5                  10                  15    
 Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe Ile Tyr Phe Thr Asp
              20                  25                  30        
 Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu Ser Phe Leu Glu Thr
          35                  40                  45            
 Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg Ala Ile Met Gly Ala
      50                  55                  60                
 Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp Ala Arg Gln Ala Leu
  65                  70                  75                  80
 Pro Arg Ala His Pro Ala Gly Ser Phe His Ala Gly Pro Gly Asp Leu
                  85                  90                  95    
 Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu His Lys Glu Phe Phe
             100                 105                 110        
 Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala Phe Tyr Pro Glu Asp
         115                 120                 125            
 Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly Trp His Ser His Thr
     130                 135                 140                
 Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu Pro Gly Pro Arg Glu
 145                 150                 155                 160
 Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg Arg Val Lys Lys Arg
                 165                 170                 175    
 His Arg Arg Gln Arg Arg Ser His Val Leu Glu Glu Gly Asp Asp Gly
             180                 185                 190        
 Asp Arg Leu Tyr Ser Ser Met Ser Arg Ala Phe Leu Tyr Arg Leu Trp
         195                 200                 205            
 Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro Arg Leu Gln Lys Ala
     210                 215                 220                
 Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly Val Arg Phe Arg Gly
 225                 230                 235                 240
 Lys Arg Glu Ala Gly Leu Ser Arg Ala Gln Leu Leu Cys Gln Leu Arg
                 245                 250                 255    
 Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr Glu Ala Pro Phe Ser
             260                 265                 270        
 Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val Pro Leu Ser Gln Leu
         275                 280                 285            
 His Pro Arg Gly Leu Arg Ser Cys Ala Val Val Met Ser Ala Gly Ala
     290                 295                 300                
 Ile Leu Asn Ser Ser Leu Gly Glu Glu Ile Asp Ser His Asp Ala Val
 305                 310                 315                 320
 Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val Gly
                 325                 330                 335    
 Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn Pro
             340                 345                 350        
 Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu Val
         355                 360                 365            
 Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr Lys
     370                 375                 380                
 Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln Arg
 385                 390                 395                 400
 Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp Gln
                 405                 410                 415    
 Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro Asn
             420                 425                 430        
 Pro Pro Ser Ser Gly Phe Ile Gly Ile Leu Ile Met Met Ser Met Cys
         435                 440                 445            
 Arg Glu Val His Val Tyr Glu Tyr Ile Pro Ser Val Arg Gln Thr Glu
     450                 455                 460                
 Leu Cys His Tyr His Glu Leu Tyr Tyr Asp Ala Ala Cys Thr Leu Gly
 465                 470                 475                 480
 Ala Tyr His Pro Leu Leu Tyr Glu Lys Leu Leu Val Gln Arg Leu Asn
                 485                 490                 495    
 Met Gly Thr Gln Gly Asp Leu His Arg Lys Gly Lys Val Val Leu Pro
             500                 505                 510        
 Gly Phe Gln Ala Val His Cys Pro Ala Pro Ser Pro Val Ile Pro His
         515                 520                 525            
 Ser
    



      <210> 1076
      <211> 423
      <212> PRT
      <213> Homo sapiens


      <400> 1076
 Met Ala Ala Trp Gly Cys Val Ala Ala Leu Gly Ala Ala Arg Gly Leu
   1               5                  10                  15    
 Cys Trp Arg Ala Ala Arg Ala Ala Ala Gly Leu Gln Gly Arg Pro Ala
              20                  25                  30        
 Arg Arg Cys Tyr Ala Val Gly Pro Ala Gln Ser Pro Pro Thr Phe Gly
          35                  40                  45            
 Phe Leu Leu Asp Ile Asp Gly Val Leu Val Arg Gly His Arg Val Ile
      50                  55                  60                
 Pro Ala Ala Leu Lys Ala Phe Arg Arg Leu Val Asn Ser Gln Gly Gln
  65                  70                  75                  80
 Leu Arg Val Pro Val Val Phe Val Thr Asn Ala Gly Asn Ile Leu Gln
                  85                  90                  95    
 His Ser Lys Ala Gln Glu Leu Ser Ala Leu Leu Gly Cys Glu Val Asp
             100                 105                 110        
 Ala Asp Gln Val Ile Leu Ser His Ser Pro Met Lys Leu Phe Ser Glu
         115                 120                 125            
 Tyr His Glu Lys Arg Met Leu Val Ser Gly Gln Gly Pro Val Met Glu
     130                 135                 140                
 Asn Ala Gln Gly Leu Gly Phe Arg Asn Val Val Thr Val Asp Glu Leu
 145                 150                 155                 160
 Arg Met Ala Phe Pro Leu Leu Asp Met Val Asp Leu Glu Arg Arg Leu
                 165                 170                 175    
 Lys Thr Thr Pro Leu Pro Arg Asn Asp Phe Pro Arg Ile Glu Gly Val
             180                 185                 190        
 Leu Leu Leu Gly Glu Pro Val Arg Trp Glu Thr Ser Leu Gln Leu Ile
         195                 200                 205            
 Met Asp Val Leu Leu Ser Asn Gly Ser Pro Gly Ala Gly Leu Ala Thr
     210                 215                 220                
 Pro Pro Tyr Pro His Leu Pro Val Leu Ala Ser Asn Met Asp Leu Leu
 225                 230                 235                 240
 Trp Met Ala Glu Ala Lys Met Pro Arg Phe Gly His Gly Thr Phe Leu
                 245                 250                 255    
 Leu Cys Leu Glu Thr Ile Tyr Gln Lys Val Thr Gly Lys Glu Leu Arg
             260                 265                 270        
 Tyr Glu Gly Leu Met Gly Lys Pro Ser Ile Leu Thr Tyr Gln Tyr Ala
         275                 280                 285            
 Glu Asp Leu Ile Arg Arg Gln Ala Glu Arg Arg Gly Trp Ala Ala Pro
     290                 295                 300                
 Ile Arg Lys Leu Tyr Ala Val Gly Asp Asn Pro Met Ser Asp Val Tyr
 305                 310                 315                 320
 Gly Ala Asn Leu Phe His Gln Tyr Leu Gln Lys Ala Thr His Asp Gly
                 325                 330                 335    
 Ala Pro Glu Leu Gly Ala Gly Gly Thr Arg Gln Gln Gln Pro Ser Ala
             340                 345                 350        
 Ser Gln Ser Cys Ile Ser Ile Leu Val Cys Thr Gly Val Tyr Asn Pro
         355                 360                 365            
 Arg Asn Pro Gln Ser Thr Glu Pro Val Leu Gly Gly Gly Glu Pro Pro
     370                 375                 380                
 Phe His Gly His Arg Asp Leu Cys Phe Ser Pro Gly Leu Met Glu Ala
 385                 390                 395                 400
 Ser His Val Val Asn Asp Val Asn Glu Ala Val Gln Leu Val Phe Arg
                 405                 410                 415    
 Lys Glu Gly Trp Ala Leu Glu
             420            



      <210> 1077
      <211> 355
      <212> PRT
      <213> Homo sapiens


      <400> 1077
 Met Ala Ala Trp Gly Cys Val Ala Ala Leu Gly Ala Ala Arg Gly Leu
   1               5                  10                  15    
 Cys Trp Arg Ala Ala Arg Ala Ala Ala Gly Leu Gln Gly Arg Pro Ala
              20                  25                  30        
 Arg Arg Cys Tyr Ala Val Gly Pro Ala Gln Val Asp Ala Asp Gln Val
          35                  40                  45            
 Ile Leu Ser His Ser Pro Met Lys Leu Phe Ser Glu Tyr His Glu Lys
      50                  55                  60                
 Arg Met Leu Val Ser Gly Gln Gly Pro Val Met Glu Asn Ala Gln Gly
  65                  70                  75                  80
 Leu Gly Phe Arg Asn Val Val Thr Val Asp Glu Leu Arg Met Ala Phe
                  85                  90                  95    
 Pro Leu Leu Asp Met Val Asp Leu Glu Arg Arg Leu Lys Thr Thr Pro
             100                 105                 110        
 Leu Pro Arg Asn Asp Phe Pro Arg Ile Glu Gly Val Leu Leu Leu Gly
         115                 120                 125            
 Glu Pro Val Arg Trp Glu Thr Ser Leu Gln Leu Ile Met Asp Val Leu
     130                 135                 140                
 Leu Ser Asn Gly Ser Pro Gly Ala Gly Leu Ala Thr Pro Pro Tyr Pro
 145                 150                 155                 160
 His Leu Pro Val Leu Ala Ser Asn Met Asp Leu Leu Trp Met Ala Glu
                 165                 170                 175    
 Ala Lys Met Pro Arg Phe Gly His Gly Thr Phe Leu Leu Cys Leu Glu
             180                 185                 190        
 Thr Ile Tyr Gln Lys Val Thr Gly Lys Glu Leu Arg Tyr Glu Gly Leu
         195                 200                 205            
 Met Gly Lys Pro Ser Ile Leu Thr Tyr Gln Tyr Ala Glu Asp Leu Ile
     210                 215                 220                
 Arg Arg Gln Ala Glu Arg Arg Gly Trp Ala Ala Pro Ile Arg Lys Leu
 225                 230                 235                 240
 Tyr Ala Val Gly Asp Asn Pro Met Ser Asp Val Tyr Gly Ala Asn Leu
                 245                 250                 255    
 Phe His Gln Tyr Leu Gln Lys Ala Thr His Asp Gly Ala Pro Glu Leu
             260                 265                 270        
 Gly Ala Gly Gly Thr Arg Gln Gln Gln Pro Ser Ala Ser Gln Ser Cys
         275                 280                 285            
 Ile Ser Ile Leu Val Cys Thr Gly Val Tyr Asn Pro Arg Asn Pro Gln
     290                 295                 300                
 Ser Thr Glu Pro Val Leu Gly Gly Gly Glu Pro Pro Phe His Gly His
 305                 310                 315                 320
 Arg Asp Leu Cys Phe Ser Pro Gly Leu Met Glu Ala Ser His Val Val
                 325                 330                 335    
 Asn Asp Val Asn Glu Ala Val Gln Leu Val Phe Arg Lys Glu Gly Trp
             340                 345                 350        
 Ala Leu Glu
         355



      <210> 1078
      <211> 1508
      <212> PRT
      <213> Homo sapiens


      <400> 1078
 Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile
   1               5                  10                  15    
 Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn
              20                  25                  30        
 Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser
          35                  40                  45            
 Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys
      50                  55                  60                
 Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser
  65                  70                  75                  80
 Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile
                  85                  90                  95    
 Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys
             100                 105                 110        
 Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys
         115                 120                 125            
 Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met
     130                 135                 140                
 Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu
 145                 150                 155                 160
 Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro
                 165                 170                 175    
 Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met
             180                 185                 190        
 Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr
         195                 200                 205            
 Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val
     210                 215                 220                
 Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile
 225                 230                 235                 240
 Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val
                 245                 250                 255    
 Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg
             260                 265                 270        
 Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys
         275                 280                 285            
 Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile
     290                 295                 300                
 Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu
 305                 310                 315                 320
 Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser
                 325                 330                 335    
 Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His
             340                 345                 350        
 Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp
         355                 360                 365            
 Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn
     370                 375                 380                
 Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro
 385                 390                 395                 400
 Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu
                 405                 410                 415    
 Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro
             420                 425                 430        
 Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr
         435                 440                 445            
 Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys
     450                 455                 460                
 Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp
 465                 470                 475                 480
 Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys
                 485                 490                 495    
 Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys
             500                 505                 510        
 Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu
         515                 520                 525            
 Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly
     530                 535                 540                
 Val Val Ala Asp Lys Ile Gln Phe Ser Val Gly Met Cys Phe Asp Asn
 545                 550                 555                 560
 Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu
                 565                 570                 575    
 Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg
             580                 585                 590        
 Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser
         595                 600                 605            
 Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro
     610                 615                 620                
 Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp
 625                 630                 635                 640
 Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln
                 645                 650                 655    
 Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe
             660                 665                 670        
 Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile
         675                 680                 685            
 Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala
     690                 695                 700                
 Met Gly Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro Leu
 705                 710                 715                 720
 His Gln Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr Trp
                 725                 730                 735    
 Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val His
             740                 745                 750        
 Val Thr Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe Cys
         755                 760                 765            
 Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu Thr
     770                 775                 780                
 Ala Phe Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val Val
 785                 790                 795                 800
 Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu Lys
                 805                 810                 815    
 Asp Cys Ile Arg Val Gln Thr Asp Leu Ala Lys Ser His Glu Tyr Gln
             820                 825                 830        
 Leu Glu Ser Trp Ala Asp Ser Gln Thr Ser Ser Cys Leu Cys Ala Asp
         835                 840                 845            
 Asp Ala Lys Thr His His Trp Asn Ile Thr Ala Val Lys Leu Gly His
     850                 855                 860                
 Ile Asn Phe Thr Ile Ser Thr Lys Ile Leu Asp Ser Asn Glu Pro Cys
 865                 870                 875                 880
 Gly Gly Gln Lys Gly Phe Val Pro Gln Lys Gly Arg Ser Asp Thr Leu
                 885                 890                 895    
 Ile Lys Pro Val Leu Val Lys Pro Glu Gly Val Leu Val Glu Lys Thr
             900                 905                 910        
 His Ser Ser Leu Leu Cys Pro Lys Gly Lys Val Ala Ser Glu Ser Val
         915                 920                 925            
 Ser Leu Glu Leu Pro Val Asp Ile Val Pro Asp Ser Thr Lys Ala Tyr
     930                 935                 940                
 Val Thr Val Leu Gly Lys Gln Leu Glu Ile Leu Asp Ser Glu Arg Lys
 945                 950                 955                 960
 Arg Arg Met Glu Ala Ala Lys Val Trp Arg Asp Ile Met Gly Thr Ala
                 965                 970                 975    
 Leu Gln Asn Leu Asp Gly Leu Val Gln Met Pro Ser Gly Cys Gly Glu
             980                 985                 990        
 Gln Asn Met Val Leu Phe Ala Pro Ile Ile Tyr Val Leu Gln Tyr Leu
         995                1000                1005            
 Glu Lys Ala Gly Leu Leu Thr Glu Glu Ile Arg Ser Arg Ala Val Gly
    1010                1015                1020                
 Phe Leu Glu Ile Gly Tyr Gln Lys Glu Leu Met Tyr Lys His Ser Asn
1025                1030                1035                1040
 Gly Ser Tyr Ser Ala Phe Gly Glu Arg Asp Gly Asn Gly Asn Thr Trp
                1045                1050                1055    
 Leu Thr Ala Phe Val Thr Lys Cys Phe Gly Gln Ala Gln Lys Phe Ile
            1060                1065                1070        
 Phe Ile Asp Pro Lys Asn Ile Gln Asp Ala Leu Lys Trp Met Ala Gly
        1075                1080                1085            
 Asn Gln Leu Pro Ser Gly Cys Tyr Ala Asn Val Gly Asn Leu Leu His
    1090                1095                1100                
 Thr Ala Met Lys Gly Gly Val Asp Asp Glu Val Ser Leu Thr Ala Tyr
1105                1110                1115                1120
 Val Thr Ala Ala Leu Leu Glu Met Gly Lys Asp Val Asp Asp Pro Met
                1125                1130                1135    
 Val Ser Gln Gly Leu Arg Cys Leu Lys Asn Ser Ala Thr Ser Thr Thr
            1140                1145                1150        
 Asn Leu Tyr Thr Gln Ala Leu Leu Ala Tyr Ile Phe Ser Leu Ala Gly
        1155                1160                1165            
 Glu Met Asp Ile Arg Asn Ile Leu Leu Lys Gln Leu Asp Gln Gln Ala
    1170                1175                1180                
 Ile Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser
1185                1190                1195                1200
 Ser Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu
                1205                1210                1215    
 Thr Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln
            1220                1225                1230        
 Lys Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln
        1235                1240                1245            
 His Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala
    1250                1255                1260                
 Leu Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Met Pro Ser Glu
1265                1270                1275                1280
 Glu Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe
                1285                1290                1295    
 Asn Ile Gln Ser Val Asn Arg Leu Val Phe Gln Gln Asp Thr Leu Pro
            1300                1305                1310        
 Asn Val Pro Gly Met Tyr Thr Leu Glu Ala Ser Gly Gln Gly Cys Val
        1315                1320                1325            
 Tyr Val Gln Thr Val Leu Arg Tyr Asn Ile Leu Pro Pro Thr Asn Met
    1330                1335                1340                
 Lys Thr Phe Ser Leu Ser Val Glu Ile Gly Lys Ala Arg Cys Glu Gln
1345                1350                1355                1360
 Pro Thr Ser Pro Arg Ser Leu Thr Leu Thr Ile His Thr Ser Tyr Val
                1365                1370                1375    
 Gly Ser Arg Ser Ser Ser Asn Met Ala Ile Val Glu Val Lys Met Leu
            1380                1385                1390        
 Ser Gly Phe Ser Pro Met Glu Gly Thr Asn Gln Leu Leu Leu Gln Gln
        1395                1400                1405            
 Pro Leu Val Lys Lys Val Glu Phe Gly Thr Asp Thr Leu Asn Ile Tyr
    1410                1415                1420                
 Leu Asp Glu Leu Ile Lys Asn Thr Gln Thr Tyr Thr Phe Thr Ile Ser
1425                1430                1435                1440
 Gln Ser Val Leu Val Thr Asn Leu Lys Pro Ala Thr Ile Lys Val Tyr
                1445                1450                1455    
 Asp Tyr Tyr Leu Pro Gly Ser Phe Lys Leu Ser Gln Tyr Thr Ile Val
            1460                1465                1470        
 Trp Ser Met Asn Asn Asp Ser Ile Val Asp Ser Val Ala Arg His Pro
        1475                1480                1485            
 Glu Pro Pro Pro Phe Lys Thr Glu Ala Phe Ile Pro Ser Leu Pro Gly
    1490                1495                1500                
 Ser Val Asn Asn
1505            



      <210> 1079
      <211> 912
      <212> PRT
      <213> Homo sapiens


      <400> 1079
 Met Ile Val Tyr Lys Phe Val Pro Val Ser Pro Thr Lys Met Trp Ala
   1               5                  10                  15    
 Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile Ala Glu Glu
              20                  25                  30        
 Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn Phe Pro Ser
          35                  40                  45            
 Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser Asp Val Lys
      50                  55                  60                
 Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys Leu Leu Glu
  65                  70                  75                  80
 Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser Phe Leu Val
                  85                  90                  95    
 Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile Arg Val Ser
             100                 105                 110        
 Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys Val Leu Ile
         115                 120                 125            
 Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys Pro Leu Tyr
     130                 135                 140                
 Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met Asp Ser Asn
 145                 150                 155                 160
 Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu Gln Asp Pro
                 165                 170                 175    
 Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro Glu Gln Gly
             180                 185                 190        
 Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met Leu Gly Thr
         195                 200                 205            
 Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr Phe Ser Val
     210                 215                 220                
 Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val Glu Pro Lys
 225                 230                 235                 240
 Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile Cys Cys Arg
                 245                 250                 255    
 Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val Ser Val Cys
             260                 265                 270        
 Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg Glu Gln Leu
         275                 280                 285            
 Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys Thr Gly Cys
     290                 295                 300                
 Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile Gly Tyr Ala
 305                 310                 315                 320
 Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu Glu Gly Thr
                 325                 330                 335    
 Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser Pro Gln Met
             340                 345                 350        
 Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His Pro Asn Phe
         355                 360                 365            
 Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp Ser Phe Leu
     370                 375                 380                
 Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn Gly Thr Phe
 385                 390                 395                 400
 Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro Phe Thr Leu
                 405                 410                 415    
 Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu Gly Lys Phe
             420                 425                 430        
 Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro Arg Tyr Tyr
         435                 440                 445            
 Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr Thr Arg Ser
     450                 455                 460                
 Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys Gly Gln Pro
 465                 470                 475                 480
 Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp Ala Ser Pro
                 485                 490                 495    
 Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys Gly Ser Leu
             500                 505                 510        
 Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys Gly Leu Lys
         515                 520                 525            
 Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu Ala Pro Asp
     530                 535                 540                
 Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly Val Val Ala
 545                 550                 555                 560
 Asp Lys Ile Gln Phe Ser Val Glu Met Cys Phe Asp Asn Gln Val Ser
                 565                 570                 575    
 Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu Val Glu Leu
             580                 585                 590        
 Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg Ala Val Asp
         595                 600                 605            
 Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser Asn Arg Ser
     610                 615                 620                
 Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro Tyr Gln Val
 625                 630                 635                 640
 Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp Phe Pro Gln
                 645                 650                 655    
 Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln Arg Ser Ile
             660                 665                 670        
 Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe Ser Phe Phe
         675                 680                 685            
 Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile Lys Lys Pro
     690                 695                 700                
 Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala Met Gly Ala
 705                 710                 715                 720
 Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro Leu His Gln
                 725                 730                 735    
 Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr Trp Leu Trp
             740                 745                 750        
 Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val His Val Thr
         755                 760                 765            
 Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe Cys Thr Ser
     770                 775                 780                
 Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu Thr Ala Phe
 785                 790                 795                 800
 Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val Val Arg Gly
                 805                 810                 815    
 Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu Lys Asp Cys
             820                 825                 830        
 Ile Arg Val Arg Ala Gly Asp Thr Gly Ile Arg Cys Gln Pro Trp Asn
         835                 840                 845            
 His Thr Ser Pro Ile Thr Leu Ser Leu Asn Trp Lys His Pro Asn Phe
     850                 855                 860                
 Pro Trp Glu Arg Glu Glu Met Ser Ala Ser Gln Pro Pro Gly Phe Pro
 865                 870                 875                 880
 Arg Pro Leu Cys Thr Thr Ser Phe Val Cys Thr Leu Cys Leu Leu Asn
                 885                 890                 895    
 Ile Leu Arg Arg Phe Arg Leu Thr Trp Leu Asn Arg Met Ser Thr Ser
             900                 905                 910        





      <210> 1080
      <211> 562
      <212> PRT
      <213> Homo sapiens


      <400> 1080
 Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile
   1               5                  10                  15    
 Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn
              20                  25                  30        
 Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser
          35                  40                  45            
 Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys
      50                  55                  60                
 Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser
  65                  70                  75                  80
 Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile
                  85                  90                  95    
 Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys
             100                 105                 110        
 Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys
         115                 120                 125            
 Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met
     130                 135                 140                
 Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu
 145                 150                 155                 160
 Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro
                 165                 170                 175    
 Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met
             180                 185                 190        
 Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr
         195                 200                 205            
 Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val
     210                 215                 220                
 Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile
 225                 230                 235                 240
 Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val
                 245                 250                 255    
 Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg
             260                 265                 270        
 Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys
         275                 280                 285            
 Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile
     290                 295                 300                
 Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu
 305                 310                 315                 320
 Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser
                 325                 330                 335    
 Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His
             340                 345                 350        
 Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp
         355                 360                 365            
 Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn
     370                 375                 380                
 Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro
 385                 390                 395                 400
 Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu
                 405                 410                 415    
 Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro
             420                 425                 430        
 Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr
         435                 440                 445            
 Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys
     450                 455                 460                
 Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp
 465                 470                 475                 480
 Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys
                 485                 490                 495    
 Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys
             500                 505                 510        
 Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu
         515                 520                 525            
 Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly
     530                 535                 540                
 Val Val Ala Asp Lys Ile Gln Phe Ser Val Gly Met Cys Phe Asp Asn
 545                 550                 555                 560
 Gln Ser
        



      <210> 1081
      <211> 1474
      <212> PRT
      <213> Homo sapiens


      <400> 1081
 Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile
   1               5                  10                  15    
 Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn
              20                  25                  30        
 Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser
          35                  40                  45            
 Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys
      50                  55                  60                
 Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser
  65                  70                  75                  80
 Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile
                  85                  90                  95    
 Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys
             100                 105                 110        
 Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys
         115                 120                 125            
 Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met
     130                 135                 140                
 Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu
 145                 150                 155                 160
 Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro
                 165                 170                 175    
 Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met
             180                 185                 190        
 Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr
         195                 200                 205            
 Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val
     210                 215                 220                
 Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile
 225                 230                 235                 240
 Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val
                 245                 250                 255    
 Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg
             260                 265                 270        
 Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys
         275                 280                 285            
 Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile
     290                 295                 300                
 Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu
 305                 310                 315                 320
 Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser
                 325                 330                 335    
 Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His
             340                 345                 350        
 Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp
         355                 360                 365            
 Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn
     370                 375                 380                
 Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro
 385                 390                 395                 400
 Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu
                 405                 410                 415    
 Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro
             420                 425                 430        
 Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr
         435                 440                 445            
 Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys
     450                 455                 460                
 Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp
 465                 470                 475                 480
 Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys
                 485                 490                 495    
 Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys
             500                 505                 510        
 Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu
         515                 520                 525            
 Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly
     530                 535                 540                
 Val Val Ala Asp Lys Ile Gln Phe Ser Val Gly Met Cys Phe Asp Asn
 545                 550                 555                 560
 Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu
                 565                 570                 575    
 Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg
             580                 585                 590        
 Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser
         595                 600                 605            
 Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro
     610                 615                 620                
 Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp
 625                 630                 635                 640
 Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln
                 645                 650                 655    
 Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe
             660                 665                 670        
 Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile
         675                 680                 685            
 Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala
     690                 695                 700                
 Met Gly Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro Leu
 705                 710                 715                 720
 His Gln Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr Trp
                 725                 730                 735    
 Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val His
             740                 745                 750        
 Val Thr Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe Cys
         755                 760                 765            
 Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu Thr
     770                 775                 780                
 Ala Phe Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val Val
 785                 790                 795                 800
 Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu Lys
                 805                 810                 815    
 Asp Cys Ile Arg Val Gln Thr Asp Leu Ala Lys Ser His Glu Tyr Gln
             820                 825                 830        
 Leu Glu Ser Trp Ala Asp Ser Gln Thr Ser Ser Cys Leu Cys Ala Asp
         835                 840                 845            
 Asp Ala Lys Thr His His Trp Asn Ile Thr Ala Val Lys Leu Gly His
     850                 855                 860                
 Ile Asn Phe Thr Ile Ser Thr Lys Ile Leu Asp Ser Asn Glu Pro Cys
 865                 870                 875                 880
 Gly Gly Gln Lys Gly Phe Val Pro Gln Lys Gly Arg Ser Asp Thr Leu
                 885                 890                 895    
 Ile Lys Pro Val Leu Val Lys Pro Glu Gly Val Leu Val Glu Lys Thr
             900                 905                 910        
 His Ser Ser Leu Leu Cys Pro Lys Gly Lys Val Ala Ser Glu Ser Val
         915                 920                 925            
 Ser Leu Glu Leu Pro Val Asp Ile Val Pro Asp Ser Thr Lys Ala Tyr
     930                 935                 940                
 Val Thr Val Leu Gly Lys Gln Leu Glu Ile Leu Asp Ser Glu Arg Lys
 945                 950                 955                 960
 Arg Arg Met Glu Ala Ala Lys Val Trp Arg Asp Ile Met Gly Thr Ala
                 965                 970                 975    
 Leu Gln Asn Leu Asp Gly Leu Val Gln Met Pro Ser Gly Cys Gly Glu
             980                 985                 990        
 Gln Asn Met Val Leu Phe Ala Pro Ile Ile Tyr Val Leu Gln Tyr Leu
         995                1000                1005            
 Glu Lys Ala Gly Leu Leu Thr Glu Glu Ile Arg Ser Arg Ala Val Gly
    1010                1015                1020                
 Phe Leu Glu Ile Gly Tyr Gln Lys Glu Leu Met Tyr Lys His Ser Asn
1025                1030                1035                1040
 Gly Ser Tyr Ser Ala Phe Gly Glu Arg Asp Gly Asn Gly Asn Thr Trp
                1045                1050                1055    
 Leu Thr Ala Phe Val Thr Lys Cys Phe Gly Gln Ala Gln Lys Phe Ile
            1060                1065                1070        
 Phe Ile Asp Pro Lys Asn Ile Gln Asp Ala Leu Lys Trp Met Ala Gly
        1075                1080                1085            
 Asn Gln Leu Pro Ser Gly Cys Tyr Ala Asn Val Gly Asn Leu Leu His
    1090                1095                1100                
 Thr Ala Met Lys Gly Gly Val Asp Asp Glu Val Ser Leu Thr Ala Tyr
1105                1110                1115                1120
 Val Thr Ala Ala Leu Leu Glu Met Gly Lys Asp Val Asp Asp Pro Met
                1125                1130                1135    
 Val Ser Gln Gly Leu Arg Cys Leu Lys Asn Ser Ala Thr Ser Thr Thr
            1140                1145                1150        
 Asn Leu Tyr Thr Gln Ala Leu Leu Ala Tyr Ile Phe Ser Leu Ala Gly
        1155                1160                1165            
 Glu Met Asp Ile Arg Asn Ile Leu Leu Lys Gln Leu Asp Gln Gln Ala
    1170                1175                1180                
 Ile Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser
1185                1190                1195                1200
 Ser Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu
                1205                1210                1215    
 Thr Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln
            1220                1225                1230        
 Lys Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln
        1235                1240                1245            
 His Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala
    1250                1255                1260                
 Leu Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Met Pro Ser Glu
1265                1270                1275                1280
 Glu Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe
                1285                1290                1295    
 Asn Ile Gln Ser Val Asn Arg Leu Val Phe Gln Gln Asp Thr Leu Pro
            1300                1305                1310        
 Asn Val Pro Gly Met Tyr Thr Leu Glu Ala Ser Gly Gln Gly Cys Val
        1315                1320                1325            
 Tyr Val Gln Thr Val Leu Arg Tyr Asn Ile Leu Pro Pro Thr Asn Met
    1330                1335                1340                
 Lys Thr Phe Ser Leu Ser Val Glu Ile Gly Lys Ala Arg Cys Glu Gln
1345                1350                1355                1360
 Pro Thr Ser Pro Arg Ser Leu Thr Leu Thr Ile His Thr Ser Tyr Val
                1365                1370                1375    
 Gly Ser Arg Ser Ser Ser Asn Met Ala Ile Val Glu Val Lys Met Leu
            1380                1385                1390        
 Ser Gly Phe Ser Pro Met Glu Gly Thr Asn Gln Leu Leu Leu Gln Gln
        1395                1400                1405            
 Pro Leu Val Lys Lys Val Glu Phe Gly Thr Asp Thr Leu Asn Ile Tyr
    1410                1415                1420                
 Leu Asp Glu Leu Ile Lys Asn Thr Gln Thr Tyr Thr Phe Thr Ile Ser
1425                1430                1435                1440
 Gln Ser Val Leu Val Thr Asn Leu Lys Pro Ala Thr Ile Lys Val Tyr
                1445                1450                1455    
 Asp Tyr Tyr Leu Pro Asp Glu Gln Ala Thr Ile Gln Tyr Ser Asp Pro
            1460                1465                1470        
 Cys Glu
        



      <210> 1082
      <211> 899
      <212> PRT
      <213> Homo sapiens


      <400> 1082
 Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile
   1               5                  10                  15    
 Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn
              20                  25                  30        
 Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser
          35                  40                  45            
 Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys
      50                  55                  60                
 Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser
  65                  70                  75                  80
 Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile
                  85                  90                  95    
 Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys
             100                 105                 110        
 Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys
         115                 120                 125            
 Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met
     130                 135                 140                
 Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu
 145                 150                 155                 160
 Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro
                 165                 170                 175    
 Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met
             180                 185                 190        
 Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr
         195                 200                 205            
 Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val
     210                 215                 220                
 Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile
 225                 230                 235                 240
 Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val
                 245                 250                 255    
 Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg
             260                 265                 270        
 Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys
         275                 280                 285            
 Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile
     290                 295                 300                
 Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu
 305                 310                 315                 320
 Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser
                 325                 330                 335    
 Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His
             340                 345                 350        
 Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp
         355                 360                 365            
 Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn
     370                 375                 380                
 Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro
 385                 390                 395                 400
 Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu
                 405                 410                 415    
 Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro
             420                 425                 430        
 Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr
         435                 440                 445            
 Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys
     450                 455                 460                
 Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp
 465                 470                 475                 480
 Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys
                 485                 490                 495    
 Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys
             500                 505                 510        
 Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu
         515                 520                 525            
 Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly
     530                 535                 540                
 Val Val Ala Asp Lys Ile Gln Phe Ser Val Glu Met Cys Phe Asp Asn
 545                 550                 555                 560
 Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu
                 565                 570                 575    
 Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg
             580                 585                 590        
 Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser
         595                 600                 605            
 Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro
     610                 615                 620                
 Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp
 625                 630                 635                 640
 Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln
                 645                 650                 655    
 Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe
             660                 665                 670        
 Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile
         675                 680                 685            
 Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala
     690                 695                 700                
 Met Gly Ala Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro
 705                 710                 715                 720
 Leu His Gln Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr
                 725                 730                 735    
 Trp Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val
             740                 745                 750        
 His Val Thr Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe
         755                 760                 765            
 Cys Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu
     770                 775                 780                
 Thr Ala Phe Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val
 785                 790                 795                 800
 Val Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu
                 805                 810                 815    
 Lys Asp Cys Ile Arg Val Arg Ala Gly Asp Thr Gly Ile Arg Cys Gln
             820                 825                 830        
 Pro Trp Asn His Thr Ser Pro Ile Thr Leu Ser Leu Asn Trp Lys His
         835                 840                 845            
 Pro Asn Phe Pro Trp Glu Arg Glu Glu Met Ser Ala Ser Gln Pro Pro
     850                 855                 860                
 Gly Phe Pro Arg Pro Leu Cys Thr Thr Ser Phe Val Cys Thr Leu Cys
 865                 870                 875                 880
 Leu Leu Asn Ile Leu Arg Arg Phe Arg Leu Thr Trp Leu Asn Arg Met
                 885                 890                 895    
 Ser Thr Ser
            



      <210> 1083
      <211> 571
      <212> PRT
      <213> Homo sapiens


      <400> 1083
 Met Glu Arg Ala Val Arg Val Glu Ser Gly Val Leu Val Gly Val Val
   1               5                  10                  15    
 Cys Leu Leu Leu Ala Cys Pro Ala Thr Ala Thr Gly Pro Glu Val Ala
              20                  25                  30        
 Gln Pro Glu Val Asp Thr Thr Leu Gly Arg Val Arg Gly Arg Gln Val
          35                  40                  45            
 Gly Val Lys Gly Thr Asp Arg Leu Val Asn Val Phe Leu Gly Ile Pro
      50                  55                  60                
 Phe Ala Gln Pro Pro Leu Gly Pro Asp Arg Phe Ser Ala Pro His Pro
  65                  70                  75                  80
 Ala Gln Pro Trp Glu Gly Val Arg Asp Ala Ser Thr Ala Pro Pro Met
                  85                  90                  95    
 Cys Leu Gln Asp Val Glu Ser Met Asn Ser Ser Arg Phe Val Leu Asn
             100                 105                 110        
 Gly Lys Gln Gln Ile Phe Ser Val Ser Glu Asp Cys Leu Val Leu Asn
         115                 120                 125            
 Val Tyr Ser Pro Ala Glu Val Pro Ala Gly Ser Gly Arg Pro Val Met
     130                 135                 140                
 Val Trp Val His Gly Gly Ala Leu Ile Thr Gly Ala Ala Thr Ser Tyr
 145                 150                 155                 160
 Asp Gly Ser Ala Leu Ala Ala Tyr Gly Asp Val Val Val Val Thr Val
                 165                 170                 175    
 Gln Tyr Arg Leu Gly Val Leu Gly Phe Phe Ser Thr Gly Asp Glu His
             180                 185                 190        
 Ala Pro Gly Asn Gln Gly Phe Leu Asp Val Val Ala Ala Leu Arg Trp
         195                 200                 205            
 Val Gln Glu Asn Ile Ala Pro Phe Gly Gly Asp Leu Asn Cys Val Thr
     210                 215                 220                
 Val Phe Gly Gly Ser Ala Gly Gly Ser Ile Ile Ser Gly Leu Val Leu
 225                 230                 235                 240
 Ser Pro Val Ala Ala Gly Leu Phe His Arg Ala Ile Thr Gln Ser Gly
                 245                 250                 255    
 Val Ile Thr Thr Pro Gly Ile Ile Asp Ser His Pro Trp Pro Leu Ala
             260                 265                 270        
 Gln Lys Ile Ala Asn Thr Leu Ala Cys Ser Ser Ser Ser Pro Ala Glu
         275                 280                 285            
 Met Val Gln Cys Leu Gln Gln Lys Glu Gly Glu Glu Leu Val Leu Ser
     290                 295                 300                
 Lys Lys Leu Lys Asn Thr Ile Tyr Pro Leu Thr Val Asp Gly Thr Val
 305                 310                 315                 320
 Phe Pro Lys Ser Pro Lys Glu Leu Leu Lys Glu Lys Pro Phe His Ser
                 325                 330                 335    
 Val Pro Phe Leu Met Gly Val Asn Asn His Glu Phe Ser Trp Leu Ile
             340                 345                 350        
 Pro Arg Gly Trp Gly Leu Leu Asp Thr Met Glu Gln Met Ser Arg Glu
         355                 360                 365            
 Asp Met Leu Ala Ile Ser Thr Pro Val Leu Thr Ser Leu Asp Val Pro
     370                 375                 380                
 Pro Glu Met Met Pro Thr Val Ile Asp Glu Tyr Leu Gly Ser Asn Ser
 385                 390                 395                 400
 Asp Ala Gln Ala Lys Cys Gln Ala Phe Gln Glu Phe Met Gly Asp Val
                 405                 410                 415    
 Phe Ile Asn Val Pro Thr Val Ser Phe Ser Arg Tyr Leu Arg Asp Ser
             420                 425                 430        
 Gly Ser Pro Val Phe Phe Tyr Glu Phe Gln His Arg Pro Ser Ser Phe
         435                 440                 445            
 Ala Lys Ile Lys Pro Ala Trp Val Lys Ala Asp His Gly Ala Glu Gly
     450                 455                 460                
 Ala Phe Val Phe Gly Gly Pro Phe Leu Met Asp Glu Ser Ser Arg Leu
 465                 470                 475                 480
 Ala Phe Pro Glu Ala Thr Glu Glu Glu Lys Gln Leu Ser Leu Thr Met
                 485                 490                 495    
 Met Ala Gln Trp Thr His Phe Ala Arg Thr Gly Asp Pro Asn Ser Lys
             500                 505                 510        
 Ala Leu Pro Pro Trp Pro Gln Phe Asn Gln Ala Glu Gln Tyr Leu Glu
         515                 520                 525            
 Ile Asn Pro Val Pro Arg Ala Gly Gln Lys Phe Arg Glu Ala Trp Met
     530                 535                 540                
 Gln Phe Trp Ser Glu Thr Leu Pro Ser Lys Ile Gln Gln Trp His Gln
 545                 550                 555                 560
 Lys Gln Lys Asn Arg Lys Ala Gln Glu Asp Leu
                 565                 570    



      <210> 1084
      <211> 1722
      <212> PRT
      <213> Homo sapiens


      <400> 1084
 Met Ala Gly Ala Trp Leu Arg Trp Gly Leu Leu Leu Trp Ala Gly Leu
   1               5                  10                  15    
 Leu Ala Ser Ser Ala His Gly Arg Leu Arg Arg Ile Thr Tyr Val Val
              20                  25                  30        
 His Pro Gly Pro Gly Leu Ala Ala Gly Ala Leu Pro Leu Ser Gly Pro
          35                  40                  45            
 Pro Ala Ser Ser Arg Thr Phe Asn Val Ala Leu Asn Ala Arg Tyr Ser
      50                  55                  60                
 Arg Ser Ser Ala Ala Ala Gly Ala Pro Ser Arg Ala Ser Pro Gly Val
  65                  70                  75                  80
 Pro Ser Glu Arg Thr Arg Arg Thr Ser Lys Pro Gly Gly Ala Ala Leu
                  85                  90                  95    
 Gln Gly Leu Arg Pro Pro Pro Pro Pro Pro Pro Glu Pro Ala Arg Pro
             100                 105                 110        
 Ala Val Pro Gly Gly Gln Leu His Pro Asn Pro Gly Gly His Pro Ala
         115                 120                 125            
 Ala Ala Pro Phe Thr Lys Gln Gly Arg Gln Val Val Arg Ser Lys Val
     130                 135                 140                
 Pro Gln Glu Thr Gln Ser Gly Gly Gly Ser Arg Leu Gln Val His Gln
 145                 150                 155                 160
 Lys Gln Gln Leu Gln Gly Val Asn Val Cys Gly Gly Arg Cys Cys His
                 165                 170                 175    
 Gly Trp Ser Lys Ala Pro Gly Ser Gln Arg Cys Thr Lys Pro Ser Cys
             180                 185                 190        
 Val Pro Pro Cys Gln Asn Gly Gly Met Cys Leu Arg Pro Gln Leu Cys
         195                 200                 205            
 Val Cys Lys Pro Gly Thr Lys Gly Lys Ala Cys Glu Thr Ile Ala Ala
     210                 215                 220                
 Gln Asp Thr Ser Ser Pro Val Phe Gly Gly Gln Ser Pro Gly Ala Ala
 225                 230                 235                 240
 Ser Ser Trp Gly Pro Pro Glu Gln Ala Ala Lys His Thr Ser Ser Lys
                 245                 250                 255    
 Lys Ala Asp Thr Leu Pro Arg Val Ser Pro Val Ala Gln Met Thr Leu
             260                 265                 270        
 Thr Leu Lys Pro Lys Pro Ser Val Gly Leu Pro Gln Gln Ile His Ser
         275                 280                 285            
 Gln Val Thr Pro Leu Ser Ser Gln Ser Val Val Ile His His Gly Gln
     290                 295                 300                
 Thr Gln Glu Tyr Val Leu Lys Pro Lys Tyr Phe Pro Ala Gln Lys Gly
 305                 310                 315                 320
 Ile Ser Gly Glu Gln Ser Thr Glu Gly Ser Phe Pro Leu Arg Tyr Val
                 325                 330                 335    
 Gln Asp Gln Val Ala Ala Pro Phe Gln Leu Ser Asn His Thr Gly Arg
             340                 345                 350        
 Ile Lys Val Val Phe Thr Pro Ser Ile Cys Lys Val Thr Cys Thr Lys
         355                 360                 365            
 Gly Ser Cys Gln Asn Ser Cys Glu Lys Gly Asn Thr Thr Thr Leu Ile
     370                 375                 380                
 Ser Glu Asn Gly His Ala Ala Asp Thr Leu Thr Ala Thr Asn Phe Arg
 385                 390                 395                 400
 Val Val Ile Cys His Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser
                 405                 410                 415    
 Arg Asp Lys Cys Gln Cys Pro Pro Asn Phe Thr Gly Lys Leu Cys Gln
             420                 425                 430        
 Ile Pro Val His Gly Ala Ser Val Pro Lys Leu Tyr Gln His Ser Gln
         435                 440                 445            
 Gln Pro Gly Lys Ala Leu Gly Thr His Val Ile His Ser Thr His Thr
     450                 455                 460                
 Leu Pro Leu Thr Val Thr Ser Gln Gln Gly Val Lys Val Lys Phe Pro
 465                 470                 475                 480
 Pro Asn Ile Val Asn Ile His Val Lys His Pro Pro Glu Ala Ser Val
                 485                 490                 495    
 Gln Ile His Gln Val Ser Arg Ile Asp Gly Pro Thr Gly Gln Lys Thr
             500                 505                 510        
 Lys Glu Ala Gln Pro Gly Gln Ser Gln Val Ser Tyr Gln Gly Leu Pro
         515                 520                 525            
 Val Gln Lys Thr Gln Thr Ile His Ser Thr Tyr Ser His Gln Gln Val
     530                 535                 540                
 Ile Pro His Val Tyr Pro Val Ala Ala Lys Thr Gln Leu Gly Arg Cys
 545                 550                 555                 560
 Phe Gln Glu Thr Ile Gly Ser Gln Cys Gly Lys Ala Leu Pro Gly Leu
                 565                 570                 575    
 Ser Lys Gln Glu Asp Cys Cys Gly Thr Val Gly Thr Ser Trp Gly Phe
             580                 585                 590        
 Asn Lys Cys Gln Lys Cys Pro Lys Lys Pro Ser Tyr His Gly Tyr Asn
         595                 600                 605            
 Gln Met Met Glu Cys Leu Pro Gly Tyr Lys Arg Val Asn Asn Thr Phe
     610                 615                 620                
 Cys Gln Asp Ile Asn Glu Cys Gln Leu Gln Gly Val Cys Pro Asn Gly
 625                 630                 635                 640
 Glu Cys Leu Asn Thr Met Gly Ser Tyr Arg Cys Thr Cys Lys Ile Gly
                 645                 650                 655    
 Phe Gly Pro Asp Pro Thr Phe Ser Ser Cys Val Pro Asp Pro Pro Val
             660                 665                 670        
 Ile Ser Glu Glu Lys Gly Pro Cys Tyr Arg Leu Val Ser Ser Gly Arg
         675                 680                 685            
 Gln Cys Met His Pro Leu Ser Val His Leu Thr Lys Gln Leu Cys Cys
     690                 695                 700                
 Cys Ser Val Gly Lys Ala Trp Gly Pro His Cys Glu Lys Cys Pro Leu
 705                 710                 715                 720
 Pro Gly Thr Ala Ala Phe Lys Glu Ile Cys Pro Gly Gly Met Gly Tyr
                 725                 730                 735    
 Thr Val Ser Gly Val His Arg Arg Arg Pro Ile His His His Val Gly
             740                 745                 750        
 Lys Gly Pro Val Phe Val Lys Pro Lys Asn Thr Gln Pro Val Ala Lys
         755                 760                 765            
 Ser Thr His Pro Pro Pro Leu Pro Ala Lys Glu Glu Pro Val Glu Ala
     770                 775                 780                
 Leu Thr Phe Ser Arg Glu His Gly Pro Gly Val Ala Glu Pro Glu Val
 785                 790                 795                 800
 Ala Thr Ala Pro Pro Glu Lys Glu Ile Pro Ser Leu Asp Gln Glu Lys
                 805                 810                 815    
 Thr Lys Leu Glu Pro Gly Gln Pro Gln Leu Ser Pro Gly Ile Ser Thr
             820                 825                 830        
 Ile His Leu His Ser Gln Phe Pro Val Val Ile Glu Lys Thr Ser Pro
         835                 840                 845            
 Pro Val Pro Val Glu Val Ala Pro Glu Ala Ser Thr Ser Ser Ala Ser
     850                 855                 860                
 Gln Val Ile Ala Pro Thr Gln Val Thr Glu Ile Asn Glu Cys Thr Val
 865                 870                 875                 880
 Asn Pro Asp Ile Cys Gly Ala Gly His Cys Ile Asn Leu Pro Val Arg
                 885                 890                 895    
 Tyr Thr Cys Ile Cys Tyr Glu Gly Tyr Arg Phe Ser Glu Gln Gln Arg
             900                 905                 910        
 Lys Cys Val Asp Ile Asp Glu Cys Thr Gln Val Gln His Leu Cys Ser
         915                 920                 925            
 Gln Gly Arg Cys Glu Asn Thr Glu Gly Ser Phe Leu Cys Ile Cys Pro
     930                 935                 940                
 Ala Gly Phe Met Ala Ser Glu Glu Gly Thr Asn Cys Ile Asp Val Asp
 945                 950                 955                 960
 Glu Cys Leu Arg Pro Asp Val Cys Gly Glu Gly His Cys Val Asn Thr
                 965                 970                 975    
 Val Gly Ala Phe Arg Cys Glu Tyr Cys Asp Ser Gly Tyr Arg Met Thr
             980                 985                 990        
 Gln Arg Gly Arg Cys Glu Asp Ile Asp Glu Cys Leu Asn Pro Ser Thr
         995                1000                1005            
 Cys Pro Asp Glu Gln Cys Val Asn Ser Pro Gly Ser Tyr Gln Cys Val
    1010                1015                1020                
 Pro Cys Thr Glu Gly Phe Arg Gly Trp Asn Gly Gln Cys Leu Asp Val
1025                1030                1035                1040
 Asp Glu Cys Leu Glu Pro Asn Val Cys Ala Asn Gly Asp Cys Ser Asn
                1045                1050                1055    
 Leu Glu Gly Ser Tyr Met Cys Ser Cys His Lys Gly Tyr Thr Arg Thr
            1060                1065                1070        
 Pro Asp His Lys His Cys Arg Asp Ile Asp Glu Cys Gln Gln Gly Asn
        1075                1080                1085            
 Leu Cys Val Asn Gly Gln Cys Lys Asn Thr Glu Gly Ser Phe Arg Cys
    1090                1095                1100                
 Thr Cys Gly Gln Gly Tyr Gln Leu Ser Ala Ala Lys Asp Gln Cys Glu
1105                1110                1115                1120
 Asp Ile Asp Glu Cys Gln His Arg His Leu Cys Ala His Gly Gln Cys
                1125                1130                1135    
 Arg Asn Thr Glu Gly Ser Phe Gln Cys Val Cys Asp Gln Gly Tyr Arg
            1140                1145                1150        
 Ala Ser Gly Leu Gly Asp His Cys Glu Asp Ile Asn Glu Cys Leu Glu
        1155                1160                1165            
 Asp Lys Ser Val Cys Gln Arg Gly Asp Cys Ile Asn Thr Ala Gly Ser
    1170                1175                1180                
 Tyr Asp Cys Thr Cys Pro Asp Gly Phe Gln Leu Asp Asp Asn Lys Thr
1185                1190                1195                1200
 Cys Gln Asp Ile Asn Glu Cys Glu His Pro Gly Leu Cys Gly Pro Gln
                1205                1210                1215    
 Gly Glu Cys Leu Asn Thr Glu Gly Ser Phe His Cys Val Cys Gln Gln
            1220                1225                1230        
 Gly Phe Ser Ile Ser Ala Asp Gly Arg Thr Cys Glu Asp Ile Asp Glu
        1235                1240                1245            
 Cys Val Asn Asn Thr Val Cys Asp Ser His Gly Phe Cys Asp Asn Thr
    1250                1255                1260                
 Ala Gly Ser Phe Arg Cys Leu Cys Tyr Gln Gly Phe Gln Ala Pro Gln
1265                1270                1275                1280
 Asp Gly Gln Gly Cys Val Asp Val Asn Glu Cys Glu Leu Leu Ser Gly
                1285                1290                1295    
 Val Cys Gly Glu Ala Phe Cys Glu Asn Val Glu Gly Ser Phe Leu Cys
            1300                1305                1310        
 Val Cys Ala Asp Glu Asn Gln Glu Tyr Ser Pro Met Thr Gly Gln Cys
        1315                1320                1325            
 Arg Ser Arg Thr Ser Thr Asp Leu Asp Val Asp Val Asp Gln Pro Lys
    1330                1335                1340                
 Lys Lys Lys Lys Glu Cys Tyr Tyr Asn Leu Asn Asp Ala Ser Leu Cys
1345                1350                1355                1360
 Asp Asn Val Leu Ala Pro Asn Val Thr Lys Gln Glu Cys Cys Cys Thr
                1365                1370                1375    
 Ser Gly Ala Gly Trp Gly Asp Asn Cys Glu Ile Phe Pro Cys Pro Val
            1380                1385                1390        
 Leu Gly Thr Ala Glu Phe Thr Glu Met Cys Pro Lys Gly Lys Gly Phe
        1395                1400                1405            
 Val Pro Ala Gly Glu Ser Ser Ser Glu Ala Gly Gly Glu Asn Tyr Lys
    1410                1415                1420                
 Asp Ala Asp Glu Cys Leu Leu Phe Gly Gln Glu Ile Cys Lys Asn Gly
1425                1430                1435                1440
 Phe Cys Leu Asn Thr Arg Pro Gly Tyr Glu Cys Tyr Cys Lys Gln Gly
                1445                1450                1455    
 Thr Tyr Tyr Asp Pro Val Lys Leu Gln Cys Phe Asp Met Asp Glu Cys
            1460                1465                1470        
 Gln Asp Pro Ser Ser Cys Ile Asp Gly Gln Cys Val Asn Thr Glu Gly
        1475                1480                1485            
 Ser Tyr Asn Cys Phe Cys Thr His Pro Met Val Leu Asp Ala Ser Glu
    1490                1495                1500                
 Lys Arg Cys Ile Arg Pro Ala Glu Ser Asn Glu Gln Ile Glu Glu Thr
1505                1510                1515                1520
 Asp Val Tyr Gln Asp Leu Cys Trp Glu His Leu Ser Asp Glu Tyr Val
                1525                1530                1535    
 Cys Ser Arg Pro Leu Val Gly Lys Gln Thr Thr Tyr Thr Glu Cys Cys
            1540                1545                1550        
 Cys Leu Tyr Gly Glu Ala Trp Gly Met Gln Cys Ala Leu Cys Pro Leu
        1555                1560                1565            
 Lys Asp Ser Asp Asp Tyr Ala Gln Leu Cys Asn Ile Pro Val Thr Gly
    1570                1575                1580                
 Arg Arg Gln Pro Tyr Gly Arg Asp Ala Leu Val Asp Phe Ser Glu Gln
1585                1590                1595                1600
 Tyr Thr Pro Glu Ala Asp Pro Tyr Phe Ile Gln Asp Arg Phe Leu Asn
                1605                1610                1615    
 Ser Phe Glu Glu Leu Gln Ala Glu Glu Cys Gly Ile Leu Asn Gly Cys
            1620                1625                1630        
 Glu Asn Gly Arg Cys Val Arg Val Gln Glu Gly Tyr Thr Cys Asp Cys
        1635                1640                1645            
 Phe Asp Gly Tyr His Leu Asp Thr Ala Lys Met Thr Cys Val Asp Val
    1650                1655                1660                
 Asn Glu Cys Asp Glu Leu Asn Asn Arg Met Ser Leu Cys Lys Asn Ala
1665                1670                1675                1680
 Lys Cys Ile Asn Thr Asp Gly Ser Tyr Lys Cys Leu Cys Leu Pro Gly
                1685                1690                1695    
 Tyr Val Pro Ser Asp Lys Pro Asn Tyr Cys Thr Pro Leu Asn Thr Ala
            1700                1705                1710        
 Leu Asn Leu Glu Lys Asp Ser Asp Leu Glu
        1715                1720        



      <210> 1085
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 1085
 Met Phe Val Glu Thr Leu Trp Lys Val Trp Thr Glu Leu Leu Asp Val
   1               5                  10                  15    
 Leu Gly Leu Asp Val Ser Asn Leu Ser Gln Tyr Phe Ser Pro Ala Ser
              20                  25                  30        
 Val Ser Ser Ser Pro Ala Arg Ala Leu Leu Leu Val Gly Val Val Leu
          35                  40                  45            
 Leu Ala Tyr Trp Phe Leu Ser Leu Thr Leu Gly Phe Thr Phe Ser Val
      50                  55                  60                
 Leu His Val Val Phe Gly Arg Phe Phe Trp Ile Val Arg Val Val Leu
  65                  70                  75                  80
 Phe Ser Met Ser Cys Val Tyr Ile Leu His Lys Tyr Glu Gly Glu Pro
                  85                  90                  95    
 Glu Asn Ala Val Leu Pro Leu Cys Phe Val Val Ala Val Tyr Phe Met
             100                 105                 110        
 Thr Gly Pro Met Gly Phe Tyr Trp Arg Ser Ser Pro Ser Gly Pro Ser
         115                 120                 125            
 Asn Pro Ser Asn Pro Ser Val Glu Glu Lys Leu Glu His Leu Glu Lys
     130                 135                 140                
 Gln Val Arg Leu Leu Asn Ile Arg Leu Asn Arg Val Leu Glu Ser Leu
 145                 150                 155                 160
 Asp Arg Ser Lys Asp Lys
                 165    



      <210> 1086
      <211> 1437
      <212> PRT
      <213> Homo sapiens


      <400> 1086
 Met Thr Leu Pro His Ser Leu Gly Gly Ala Gly Asp Pro Arg Pro Pro
   1               5                  10                  15    
 Gln Ala Met Glu Val His Arg Leu Glu His Arg Gln Glu Glu Glu Gln
              20                  25                  30        
 Lys Glu Glu Arg Gln His Ser Leu Arg Met Gly Ser Ser Val Arg Arg
          35                  40                  45            
 Arg Thr Phe Arg Ser Ser Glu Glu Glu His Glu Phe Ser Ala Ala Asp
      50                  55                  60                
 Tyr Ala Leu Ala Ala Ala Leu Ala Leu Thr Ala Ser Ser Glu Leu Ser
  65                  70                  75                  80
 Trp Glu Ala Gln Leu Arg Arg Gln Thr Ser Ala Val Glu Leu Glu Glu
                  85                  90                  95    
 Arg Gly Gln Lys Arg Val Gly Phe Gly Asn Asp Trp Glu Arg Thr Glu
             100                 105                 110        
 Ile Ala Phe Leu Gln Thr His Arg Leu Leu Arg Gln Arg Arg Asp Trp
         115                 120                 125            
 Lys Thr Leu Arg Arg Arg Thr Glu Glu Lys Val Gln Glu Ala Lys Glu
     130                 135                 140                
 Leu Arg Glu Leu Cys Tyr Gly Arg Gly Pro Trp Phe Trp Ile Pro Leu
 145                 150                 155                 160
 Arg Ser His Ala Val Trp Glu His Thr Thr Val Leu Leu Thr Cys Thr
                 165                 170                 175    
 Val Gln Ala Ser Pro Pro Pro Gln Val Thr Trp Tyr Lys Asn Asp Thr
             180                 185                 190        
 Arg Ile Asp Pro Arg Leu Phe Arg Ala Gly Lys Tyr Arg Ile Thr Asn
         195                 200                 205            
 Asn Tyr Gly Leu Leu Ser Leu Glu Ile Arg Arg Cys Ala Ile Glu Asp
     210                 215                 220                
 Ser Ala Thr Tyr Thr Val Arg Val Lys Asn Ala His Gly Gln Ala Ser
 225                 230                 235                 240
 Ser Phe Ala Lys Val Leu Val Arg Thr Tyr Leu Gly Lys Asp Ala Gly
                 245                 250                 255    
 Phe Asp Ser Glu Ile Phe Lys Arg Ser Thr Phe Gly Pro Ser Val Glu
             260                 265                 270        
 Phe Thr Ser Val Leu Lys Pro Val Phe Ala Arg Glu Lys Glu Pro Phe
         275                 280                 285            
 Ser Leu Ser Cys Leu Phe Ser Glu Asp Val Leu Asp Ala Glu Ser Ile
     290                 295                 300                
 Gln Trp Phe Arg Asp Gly Ser Leu Leu Arg Ser Ser Arg Arg Arg Lys
 305                 310                 315                 320
 Ile Leu Tyr Thr Asp Arg Gln Ala Ser Leu Lys Val Ser Cys Thr Tyr
                 325                 330                 335    
 Lys Glu Asp Glu Gly Leu Tyr Met Val Arg Val Pro Ser Pro Phe Gly
             340                 345                 350        
 Pro Arg Glu Gln Ser Thr Tyr Val Leu Val Arg Asp Ala Glu Ala Glu
         355                 360                 365            
 Asn Pro Gly Ala Pro Gly Ser Pro Leu Asn Val Arg Cys Leu Asp Val
     370                 375                 380                
 Asn Arg Asp Cys Leu Ile Leu Thr Trp Ala Pro Pro Ser Asp Thr Arg
 385                 390                 395                 400
 Gly Asn Pro Ile Thr Ala Tyr Thr Ile Glu Arg Cys Gln Gly Glu Ser
                 405                 410                 415    
 Gly Glu Trp Ile Ala Cys His Glu Ala Pro Gly Gly Thr Cys Arg Cys
             420                 425                 430        
 Pro Ile Gln Gly Leu Val Glu Gly Gln Ser Tyr Arg Phe Arg Val Arg
         435                 440                 445            
 Ala Ile Ser Arg Val Gly Ser Ser Val Pro Ser Lys Ala Ser Glu Leu
     450                 455                 460                
 Val Val Met Gly Asp His Asp Ala Ala Arg Arg Lys Thr Glu Ile Pro
 465                 470                 475                 480
 Phe Asp Leu Gly Asn Lys Ile Thr Ile Ser Thr Asp Ala Phe Glu Asp
                 485                 490                 495    
 Thr Val Thr Ile Pro Ser Pro Pro Thr Asn Val His Ala Ser Glu Ile
             500                 505                 510        
 Arg Glu Ala Tyr Val Val Leu Ala Trp Glu Glu Pro Ser Pro Arg Gly
         515                 520                 525            
 Arg Ala Pro Leu Thr Tyr Ser Leu Glu Lys Ser Val Ile Gly Ser Gly
     530                 535                 540                
 Thr Trp Glu Ala Ile Ser Ser Glu Ser Pro Val Arg Ser Pro Arg Phe
 545                 550                 555                 560
 Ala Val Leu Asp Leu Glu Lys Lys Lys Ser Tyr Val Phe Arg Val Arg
                 565                 570                 575    
 Ala Met Asn Gln Tyr Gly Leu Ser Asp Pro Ser Glu Pro Ser Glu Pro
             580                 585                 590        
 Ile Ala Leu Arg Gly Pro Pro Ala Thr Leu Pro Pro Pro Ala Gln Val
         595                 600                 605            
 Gln Ala Phe Arg Asp Thr Gln Thr Ser Val Ser Leu Thr Trp Asp Pro
     610                 615                 620                
 Val Lys Asp Pro Glu Leu Leu Gly Tyr Tyr Ile Tyr Ser Arg Lys Val
 625                 630                 635                 640
 Gly Thr Ser Glu Trp Gln Thr Val Asn Asn Lys Pro Ile Gln Gly Thr
                 645                 650                 655    
 Arg Phe Thr Val Pro Gly Leu Arg Thr Gly Lys Glu Tyr Glu Phe Cys
             660                 665                 670        
 Val Arg Ser Val Ser Glu Ala Gly Val Gly Glu Ser Ser Ala Ala Thr
         675                 680                 685            
 Glu Pro Ile Arg Val Lys Gln Ala Leu Ala Thr Pro Ser Ala Pro Tyr
     690                 695                 700                
 Gly Phe Ala Leu Leu Asn Cys Gly Lys Asn Glu Met Val Ile Gly Trp
 705                 710                 715                 720
 Lys Pro Pro Lys Arg Arg Gly Gly Gly Lys Ile Leu Gly Tyr Phe Leu
                 725                 730                 735    
 Asp Gln His Asp Ser Glu Glu Leu Asp Trp His Ala Val Asn Gln Gln
             740                 745                 750        
 Pro Ile Pro Thr Arg Val Cys Lys Val Ser Asp Leu His Glu Gly His
         755                 760                 765            
 Phe Tyr Glu Phe Arg Ala Arg Ala Ala Asn Trp Ala Gly Val Gly Glu
     770                 775                 780                
 Leu Ser Ala Pro Ser Ser Leu Phe Glu Cys Lys Glu Trp Thr Met Pro
 785                 790                 795                 800
 Gln Pro Gly Pro Pro Tyr Asp Val Arg Ala Ser Glu Val Arg Ala Thr
                 805                 810                 815    
 Ser Leu Val Leu Gln Trp Glu Pro Pro Leu Tyr Met Gly Ala Gly Pro
             820                 825                 830        
 Val Thr Gly Tyr His Val Ser Phe Gln Glu Glu Gly Ser Glu Gln Trp
         835                 840                 845            
 Lys Pro Val Thr Pro Gly Pro Ile Ser Gly Thr His Leu Arg Val Ser
     850                 855                 860                
 Asp Leu Gln Pro Gly Lys Ser Tyr Val Phe Gln Val Gln Ala Met Asn
 865                 870                 875                 880
 Ser Ala Gly Leu Gly Gln Pro Ser Met Pro Thr Asp Pro Val Leu Leu
                 885                 890                 895    
 Glu Asp Lys Pro Gly Ala His Glu Ile Glu Val Gly Val Asp Glu Glu
             900                 905                 910        
 Gly Phe Ile Tyr Leu Ala Phe Glu Ala Pro Glu Ala Pro Asp Ser Ser
         915                 920                 925            
 Glu Phe Gln Trp Ser Lys Asp Tyr Lys Gly Pro Leu Asp Pro Gln Arg
     930                 935                 940                
 Val Lys Ile Glu Asp Lys Val Asn Lys Ser Lys Val Ile Leu Lys Glu
 945                 950                 955                 960
 Pro Gly Leu Glu Asp Leu Gly Thr Tyr Ser Val Ile Val Thr Asp Ala
                 965                 970                 975    
 Asp Glu Asp Ile Ser Ala Ser His Thr Leu Thr Glu Glu Glu Leu Glu
             980                 985                 990        
 Lys Leu Lys Lys Leu Ser His Glu Ile Arg Asn Pro Val Ile Lys Leu
         995                1000                1005            
 Ile Ser Gly Trp Asn Ile Asp Ile Leu Glu Arg Gly Glu Val Arg Leu
    1010                1015                1020                
 Trp Leu Glu Val Glu Lys Leu Ser Pro Ala Ala Glu Leu His Leu Ile
1025                1030                1035                1040
 Phe Asn Asn Lys Glu Ile Phe Ser Ser Pro Asn Arg Lys Ile Asn Phe
                1045                1050                1055    
 Asp Arg Glu Lys Gly Leu Val Glu Val Ile Ile Gln Asn Leu Ser Glu
            1060                1065                1070        
 Glu Asp Lys Gly Ser Tyr Thr Ala Gln Leu Gln Asp Gly Lys Ala Lys
        1075                1080                1085            
 Asn Gln Ile Thr Leu Thr Leu Val Asp Asp Asp Phe Asp Lys Leu Leu
    1090                1095                1100                
 Arg Lys Ala Asp Ala Lys Arg Arg Asp Trp Lys Arg Lys Gln Gly Pro
1105                1110                1115                1120
 Tyr Phe Glu Arg Pro Leu Gln Trp Lys Val Thr Glu Asp Cys Gln Val
                1125                1130                1135    
 Gln Leu Thr Cys Lys Val Thr Asn Thr Lys Lys Glu Thr Arg Phe Gln
            1140                1145                1150        
 Trp Phe Phe Gln Arg Ala Glu Met Pro Asp Gly Gln Tyr Asp Pro Glu
        1155                1160                1165            
 Thr Gly Thr Gly Leu Leu Cys Ile Glu Glu Leu Ser Lys Lys Asp Lys
    1170                1175                1180                
 Gly Ile Tyr Arg Ala Met Val Ser Asp Asp Arg Gly Glu Asp Asp Thr
1185                1190                1195                1200
 Ile Leu Asp Leu Thr Gly Asp Ala Leu Asp Ala Ile Phe Thr Glu Leu
                1205                1210                1215    
 Gly Arg Ile Gly Ala Leu Ser Ala Thr Pro Leu Lys Ile Gln Gly Thr
            1220                1225                1230        
 Glu Glu Gly Ile Arg Ile Phe Ser Lys Val Lys Tyr Tyr Asn Val Glu
        1235                1240                1245            
 Tyr Met Lys Thr Thr Trp Phe His Lys Asp Lys Arg Leu Glu Ser Gly
    1250                1255                1260                
 Asp Arg Ile Arg Thr Gly Thr Thr Leu Asp Glu Ile Trp Leu His Ile
1265                1270                1275                1280
 Leu Asp Pro Lys Asp Ser Asp Lys Gly Lys Tyr Thr Leu Glu Ile Ala
                1285                1290                1295    
 Ala Gly Lys Glu Val Arg Gln Leu Ser Thr Asp Leu Ser Gly Gln Ala
            1300                1305                1310        
 Phe Glu Asp Ala Met Ala Glu His Gln Arg Leu Lys Thr Leu Ala Ile
        1315                1320                1325            
 Ile Glu Lys Asn Arg Ala Lys Val Val Arg Gly Leu Pro Asp Val Ala
    1330                1335                1340                
 Thr Ile Met Glu Asp Lys Thr Leu Cys Leu Thr Cys Ile Val Ser Gly
1345                1350                1355                1360
 Asp Pro Thr Pro Glu Ile Ser Trp Leu Lys Asn Asp Gln Pro Val Thr
                1365                1370                1375    
 Phe Leu Asp Arg Tyr Arg Met Glu Val Arg Gly Thr Glu Val Thr Ile
            1380                1385                1390        
 Thr Ile Glu Lys Val Asn Ser Glu Asp Ser Gly Arg Tyr Gly Val Phe
        1395                1400                1405            
 Val Lys Asn Lys Tyr Gly Ser Glu Thr Gly Gln Val Thr Ile Ser Val
    1410                1415                1420                
 Phe Lys His Gly Asp Glu Pro Lys Glu Leu Lys Ser Met
1425                1430                1435        



      <210> 1087
      <211> 269
      <212> PRT
      <213> Homo sapiens


      <400> 1087
 Met Ala Ala Ala Thr Leu Arg Thr Pro Thr Gln Gly Thr Val Thr Phe
   1               5                  10                  15    
 Glu Asp Val Ala Val His Phe Ser Trp Glu Glu Trp Gly Leu Leu Asp
              20                  25                  30        
 Glu Ala Gln Arg Cys Leu Tyr Arg Asp Val Met Leu Glu Asn Leu Ala
          35                  40                  45            
 Leu Leu Thr Ser Leu Asp Val His His Gln Lys Gln His Leu Gly Glu
      50                  55                  60                
 Lys His Phe Arg Ser Asn Val Gly Arg Ala Leu Phe Val Lys Thr Cys
  65                  70                  75                  80
 Thr Phe His Val Ser Gly Glu Pro Ser Thr Cys Arg Glu Val Gly Lys
                  85                  90                  95    
 Asp Phe Leu Ala Lys Leu Gly Phe Leu His Gln Gln Ala Ala His Thr
             100                 105                 110        
 Gly Glu Gln Ser Asn Ser Lys Ser Asp Val Gly Ala Ile Ser His Arg
         115                 120                 125            
 Gly Lys Thr His Tyr Asn Cys Gly Glu His Thr Lys Ala Phe Gly Ser
     130                 135                 140                
 Lys His Thr Leu Val Gln Gln Gln Arg Thr Leu Thr Thr Glu Arg Cys
 145                 150                 155                 160
 Tyr Ile Cys Ser Glu Cys Gly Lys Ser Phe Ser Lys Ser Tyr Ser Leu
                 165                 170                 175    
 Asn Asp His Trp Arg Leu His Thr Gly Glu Lys Pro Tyr Glu Cys Arg
             180                 185                 190        
 Glu Cys Gly Lys Ser Phe Arg Gln Ser Ser Ser Leu Ile Gln His Arg
         195                 200                 205            
 Arg Val His Thr Ala Val Arg Pro His Glu Cys Asp Glu Cys Gly Lys
     210                 215                 220                
 Leu Phe Ser Asn Lys Ser Asn Leu Ile Lys His Arg Arg Val His Thr
 225                 230                 235                 240
 Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys Ser Phe Ser His
                 245                 250                 255    
 Asn Ser Ser Leu Ile Lys His Gln Arg Ile His Ser Arg
             260                 265                



      <210> 1088
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 1088
 Met Ala Ala Ala Thr Leu Arg Thr Pro Thr Gln Gly Thr Val Thr Phe
   1               5                  10                  15    
 Glu Asp Val Ala Val His Phe Ser Trp Glu Glu Trp Gly Leu Leu Asp
              20                  25                  30        
 Glu Ala Gln Arg Cys Leu Tyr Arg Asp Val Met Leu Glu Asn Leu Ala
          35                  40                  45            
 Leu Leu Thr Ser Leu Asp Val His His Gln Lys Gln His Leu Gly Glu
      50                  55                  60                
 Lys His Phe Arg Ser Asn Val Gly Arg Ala Leu Phe Val Lys Thr Cys
  65                  70                  75                  80
 Thr Phe His Val Ser Gly Glu Pro Ser Thr Cys Arg Glu Val Gly Lys
                  85                  90                  95    
 Asp Phe Leu Ala Lys Leu Gly Phe Leu His Gln Gln Ala Ala His Thr
             100                 105                 110        
 Gly Glu Gln Ser Asn Ser Lys Ser Asp Gly Gly Ala Ile Ser His Arg
         115                 120                 125            
 Gly Lys Thr His Tyr Asn Cys Gly Glu His Thr Lys Ala Phe Ser Gly
     130                 135                 140                
 Lys His Thr Leu Val Gln Gln Gln Arg Thr Leu Thr Thr Glu Arg Cys
 145                 150                 155                 160
 Tyr Ile Cys Ser Glu Cys Gly Lys Ser Phe Ser His Asn Ser Ser Leu
                 165                 170                 175    
 Ile Lys His Gln Arg Ile His Ser Arg
             180                 185



      <210> 1089
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 1089
 Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly
   1               5                  10                  15    
 Leu Glu Thr Cys Cys Arg Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg
              20                  25                  30        
 Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro
          35                  40                  45            
 Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser
      50                  55                  60                
 Cys Cys Thr Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys
  65                  70                  75                  80
 Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln
                  85                  90                  95    
 Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys Cys Ile Ser
             100                 105                 110        
 Ser Cys Cys Arg Pro Ser Cys Cys Glu Ser Ser Cys Cys Arg Pro Cys
         115                 120                 125            
 Cys Cys Arg Pro Cys Cys Cys Leu Arg Pro Val Cys Gly Arg Val Ser
     130                 135                 140                
 Cys His Thr Thr Cys Tyr Arg Pro Thr Cys Val Ile Ser Thr Cys Pro
 145                 150                 155                 160
 Arg Pro Leu Cys Cys Ala Ser Ser Cys Cys
                 165                 170



      <210> 1090
      <211> 75
      <212> PRT
      <213> Homo sapiens


      <400> 1090
 Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly
   1               5                  10                  15    
 Leu Glu Thr Cys Cys Arg Pro Ser Cys Cys Pro Ser Cys Cys Gln Thr
              20                  25                  30        
 Thr Cys Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser
          35                  40                  45            
 Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys
      50                  55                  60                
 Pro Arg Pro Leu Cys Cys Ala Ser Ser Cys Cys
  65                  70                  75



      <210> 1091
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 1091
 Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly
   1               5                  10                  15    
 Leu Glu Thr Cys Cys Arg Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg
              20                  25                  30        
 Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro
          35                  40                  45            
 Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser
      50                  55                  60                
 Cys Cys Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys
  65                  70                  75                  80
 Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln
                  85                  90                  95    
 Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys Ser Ile Ser
             100                 105                 110        
 Ser Cys Cys Arg Pro Ser Cys Cys Val Ser Arg Cys Cys Arg Ser Gln
         115                 120                 125            
 Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys
     130                 135                 140                
 Cys Ile Ser Ser Cys Cys Arg Pro Ser Cys Cys Glu Ser Ser Cys Cys
 145                 150                 155                 160
 Arg Pro Cys Cys Cys Arg Pro Cys Cys Cys Leu Arg Pro Val Cys Gly
                 165                 170                 175    
 Arg Val Ser Cys His Thr Thr Cys Tyr Arg Pro Thr Cys Val Ile Ser
             180                 185                 190        
 Thr Cys Pro Arg Pro Leu Cys Cys Ala Ser Ser Cys Cys
         195                 200                 205



      <210> 1092
      <211> 409
      <212> PRT
      <213> Homo sapiens


      <400> 1092
 Met Glu Met Trp Leu Leu Ile Leu Val Ala Tyr Met Phe Gln Arg Asn
   1               5                  10                  15    
 Val Asn Ser Val His Met Pro Thr Lys Ala Val Asp Pro Glu Ala Phe
              20                  25                  30        
 Met Asn Ile Ser Glu Ile Ile Gln His Gln Gly Tyr Pro Cys Glu Glu
          35                  40                  45            
 Tyr Glu Val Ala Thr Glu Asp Gly Tyr Ile Leu Ser Val Asn Arg Ile
      50                  55                  60                
 Pro Arg Gly Leu Val Gln Pro Lys Lys Thr Gly Ser Arg Pro Val Val
  65                  70                  75                  80
 Leu Leu Gln His Gly Leu Val Gly Gly Ala Ser Asn Trp Ile Ser Asn
                  85                  90                  95    
 Leu Pro Asn Asn Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp
             100                 105                 110        
 Val Trp Met Gly Asn Ser Arg Gly Asn Ala Trp Ser Arg Lys His Lys
         115                 120                 125            
 Thr Leu Ser Ile Asp Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu
     130                 135                 140                
 Met Ala Arg Phe Asp Leu Pro Ala Val Ile Asn Phe Ile Leu Gln Lys
 145                 150                 155                 160
 Thr Gly Gln Glu Lys Ile Tyr Tyr Val Gly Tyr Ser Gln Gly Thr Thr
                 165                 170                 175    
 Met Gly Phe Ile Ala Phe Ser Thr Met Pro Glu Leu Ala Gln Lys Ile
             180                 185                 190        
 Lys Met Tyr Phe Ala Leu Ala Pro Ile Ala Thr Val Lys His Ala Lys
         195                 200                 205            
 Ser Pro Gly Thr Lys Phe Leu Leu Leu Pro Asp Met Met Ile Lys Gly
     210                 215                 220                
 Leu Phe Gly Lys Lys Glu Phe Leu Tyr Gln Thr Arg Phe Leu Arg Gln
 225                 230                 235                 240
 Leu Val Ile Tyr Leu Cys Gly Gln Val Ile Leu Asp Gln Ile Cys Ser
                 245                 250                 255    
 Asn Ile Met Leu Leu Leu Gly Gly Phe Asn Thr Asn Asn Met Asn Met
             260                 265                 270        
 Ser Arg Ala Ser Val Tyr Ala Ala His Thr Leu Ala Gly Thr Ser Val
         275                 280                 285            
 Gln Asn Ile Leu His Trp Ser Gln Ala Val Asn Ser Gly Glu Leu Arg
     290                 295                 300                
 Ala Phe Asp Trp Gly Ser Glu Thr Lys Asn Leu Glu Lys Cys Asn Gln
 305                 310                 315                 320
 Pro Thr Pro Val Arg Tyr Arg Val Arg Asp Met Thr Val Pro Thr Ala
                 325                 330                 335    
 Met Trp Thr Gly Gly Gln Asp Trp Leu Ser Asn Pro Glu Asp Val Lys
             340                 345                 350        
 Met Leu Leu Ser Glu Val Thr Asn Leu Ile Tyr His Lys Asn Ile Pro
         355                 360                 365            
 Glu Trp Ala His Val Asp Phe Ile Trp Gly Leu Asp Ala Pro His Arg
     370                 375                 380                
 Met Tyr Asn Glu Ile Ile His Leu Met Gln Gln Glu Glu Thr Asn Leu
 385                 390                 395                 400
 Ser Gln Gly Arg Cys Glu Ala Val Leu
                 405                



      <210> 1093
      <211> 458
      <212> PRT
      <213> Homo sapiens


      <400> 1093
 Ala Cys Leu Ile Cys Phe Arg Ile Gly Arg Gly Asn Cys Ser Arg Lys
   1               5                  10                  15    
 Ile Cys Glu Glu Phe Leu Asn Pro Gln Ile Leu Leu Thr Leu Glu Leu
              20                  25                  30        
 Val Val Thr Leu Ala Gly Lys Asn Lys Cys Arg Cys Trp Thr Met Leu
          35                  40                  45            
 Glu Thr Leu Ser Arg Gln Trp Ile Val Ser His Arg Met Glu Met Trp
      50                  55                  60                
 Leu Leu Ile Leu Val Ala Tyr Met Phe Gln Arg Asn Val Asn Ser Val
  65                  70                  75                  80
 His Met Pro Thr Lys Ala Val Asp Pro Glu Ala Phe Met Asn Ile Ser
                  85                  90                  95    
 Glu Ile Ile Gln His Gln Gly Tyr Pro Cys Glu Glu Tyr Glu Val Ala
             100                 105                 110        
 Thr Glu Asp Gly Tyr Ile Leu Ser Val Asn Arg Ile Pro Arg Gly Leu
         115                 120                 125            
 Val Gln Pro Lys Lys Thr Gly Ser Arg Pro Val Val Leu Leu Gln His
     130                 135                 140                
 Gly Leu Val Gly Gly Ala Ser Asn Trp Ile Ser Asn Leu Pro Asn Asn
 145                 150                 155                 160
 Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly
                 165                 170                 175    
 Asn Ser Arg Gly Asn Ala Trp Ser Arg Lys His Lys Thr Leu Ser Ile
             180                 185                 190        
 Asp Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Arg Phe
         195                 200                 205            
 Asp Leu Pro Ala Val Ile Asn Phe Ile Leu Gln Lys Thr Gly Gln Glu
     210                 215                 220                
 Lys Ile Tyr Tyr Val Gly Tyr Ser Gln Gly Thr Thr Met Gly Phe Ile
 225                 230                 235                 240
 Ala Phe Ser Thr Met Pro Glu Leu Ala Gln Lys Ile Lys Met Tyr Phe
                 245                 250                 255    
 Ala Leu Ala Pro Ile Ala Thr Val Lys His Ala Lys Ser Pro Gly Thr
             260                 265                 270        
 Lys Phe Leu Leu Leu Pro Asp Met Met Ile Lys Gly Leu Phe Gly Lys
         275                 280                 285            
 Lys Glu Phe Leu Tyr Gln Thr Arg Phe Leu Arg Gln Leu Val Ile Tyr
     290                 295                 300                
 Leu Cys Gly Gln Val Ile Leu Asp Gln Ile Cys Ser Asn Ile Met Leu
 305                 310                 315                 320
 Leu Leu Gly Gly Phe Asn Thr Asn Asn Met Asn Met Ser Arg Ala Ser
                 325                 330                 335    
 Val Tyr Ala Ala His Thr Leu Ala Gly Thr Ser Val Gln Asn Ile Leu
             340                 345                 350        
 His Trp Ser Gln Ala Val Asn Ser Gly Glu Leu Arg Ala Phe Asp Trp
         355                 360                 365            
 Gly Ser Glu Thr Lys Asn Leu Glu Lys Cys Asn Gln Pro Thr Pro Val
     370                 375                 380                
 Arg Tyr Arg Val Arg Asp Met Thr Val Pro Thr Ala Met Trp Thr Gly
 385                 390                 395                 400
 Gly Gln Asp Trp Leu Ser Asn Pro Glu Asp Val Lys Met Leu Leu Ser
                 405                 410                 415    
 Glu Val Thr Asn Leu Ile Tyr His Lys Asn Ile Pro Glu Trp Ala His
             420                 425                 430        
 Val Asp Phe Ile Trp Gly Leu Asp Ala Pro His Arg Met Tyr Asn Glu
         435                 440                 445            
 Ile Ile His Leu Met Gln Gln Glu Glu Thr
     450                 455            



      <210> 1094
      <211> 345
      <212> PRT
      <213> Homo sapiens


      <400> 1094
 Met Tyr Lys Asp Cys Ile Glu Ser Thr Gly Asp Tyr Phe Leu Leu Cys
   1               5                  10                  15    
 Asp Ala Glu Gly Pro Trp Gly Ile Ile Leu Glu Ser Leu Ala Ile Leu
              20                  25                  30        
 Gly Ile Val Val Thr Ile Leu Leu Leu Leu Ala Phe Leu Phe Leu Met
          35                  40                  45            
 Arg Lys Ile Gln Asp Cys Ser Gln Trp Asn Val Leu Pro Thr Gln Leu
      50                  55                  60                
 Leu Phe Leu Leu Ser Val Leu Gly Leu Phe Gly Leu Ala Phe Ala Phe
  65                  70                  75                  80
 Ile Ile Glu Leu Asn Gln Gln Thr Ala Pro Val Arg Tyr Phe Leu Phe
                  85                  90                  95    
 Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu Ala His Ala Ser
             100                 105                 110        
 Asn Leu Val Lys Leu Val Arg Gly Cys Val Ser Phe Ser Trp Thr Thr
         115                 120                 125            
 Ile Leu Cys Ile Ala Ile Gly Cys Ser Leu Leu Gln Ile Ile Ile Ala
     130                 135                 140                
 Thr Glu Tyr Val Thr Leu Ile Met Thr Arg Gly Met Met Phe Val Asn
 145                 150                 155                 160
 Met Thr Pro Cys Gln Leu Asn Val Asp Phe Val Val Leu Leu Val Tyr
                 165                 170                 175    
 Val Leu Phe Leu Met Ala Leu Thr Phe Phe Val Ser Lys Ala Thr Phe
             180                 185                 190        
 Cys Gly Pro Gly Glu Asn Trp Lys Gln His Gly Arg Leu Ile Phe Ile
         195                 200                 205            
 Thr Val Leu Phe Ser Ile Ile Ile Trp Val Val Trp Ile Ser Met Leu
     210                 215                 220                
 Leu Arg Gly Asn Pro Gln Phe Gln Arg Gln Pro Gln Trp Asp Asp Pro
 225                 230                 235                 240
 Val Val Cys Ile Ala Leu Val Thr Asn Ala Trp Val Phe Leu Leu Leu
                 245                 250                 255    
 Tyr Ile Val Pro Glu Leu Cys Ile Leu Tyr Arg Ser Cys Arg Gln Glu
             260                 265                 270        
 Cys Pro Leu Gln Gly Asn Ala Cys Pro Val Thr Ala Tyr Gln His Ser
         275                 280                 285            
 Phe Gln Val Glu Asn Gln Glu Leu Ser Arg Ala Arg Asp Ser Asp Gly
     290                 295                 300                
 Ala Glu Glu Asp Val Ala Leu Thr Ser Tyr Gly Thr Pro Ile Gln Pro
 305                 310                 315                 320
 Gln Thr Val Asp Pro Thr Gln Glu Cys Phe Ile Pro Gln Ala Lys Leu
                 325                 330                 335    
 Ser Pro Gln Gln Asp Ala Gly Gly Val
             340                 345



      <210> 1095
      <211> 225
      <212> PRT
      <213> Homo sapiens


      <400> 1095
 Met Ala Phe Phe Ser Arg Leu Asn Leu Gln Glu Gly Leu Gln Thr Phe
   1               5                  10                  15    
 Phe Val Leu Gln Trp Ile Pro Val Tyr Ile Phe Leu Gly Ala Ile Pro
              20                  25                  30        
 Ile Leu Leu Ile Pro Tyr Phe Leu Leu Phe Ser Lys Phe Trp Pro Leu
          35                  40                  45            
 Ala Val Leu Ser Leu Ala Trp Leu Thr Tyr Asp Trp Asn Thr His Ser
      50                  55                  60                
 Gln Gly Gly Arg Arg Ser Ala Trp Val Arg Asn Trp Thr Leu Trp Lys
  65                  70                  75                  80
 Tyr Phe Arg Asn Tyr Phe Pro Val Lys Leu Val Lys Thr His Asp Leu
                  85                  90                  95    
 Ser Pro Lys His Asn Tyr Ile Ile Ala Asn His Pro His Gly Ile Leu
             100                 105                 110        
 Ser Phe Gly Val Phe Ile Asn Phe Ala Thr Glu Ala Thr Gly Ile Ala
         115                 120                 125            
 Arg Ile Phe Pro Ser Ile Thr Pro Phe Val Gly Thr Leu Glu Arg Ile
     130                 135                 140                
 Phe Trp Ile Pro Ile Val Arg Glu Tyr Val Met Ser Met Gly Val Cys
 145                 150                 155                 160
 Pro Val Ser Ser Ser Ala Leu Lys Tyr Leu Leu Thr Gln Lys Gly Ser
                 165                 170                 175    
 Gly Asn Ala Val Val Ile Val Val Gly Gly Ala Ala Glu Ala Leu Leu
             180                 185                 190        
 Cys Arg Pro Gly Ala Ser Thr Leu Phe Leu Lys Gln Arg Lys Gly Phe
         195                 200                 205            
 Val Lys Met Ala Leu Gln Thr Gly Trp Gly Thr Pro Ser Asn Ser Gln
     210                 215                 220                
 Asp
 225



      <210> 1096
      <211> 234
      <212> PRT
      <213> Homo sapiens


      <400> 1096
 Met Val Pro Glu Glu Glu Pro Gln Asp Arg Glu Lys Gly Leu Trp Trp
   1               5                  10                  15    
 Phe Gln Leu Lys Val Trp Ser Met Ala Val Val Ser Ile Leu Leu Leu
              20                  25                  30        
 Ser Val Cys Phe Thr Val Ser Ser Val Val Pro His Asn Phe Met Tyr
          35                  40                  45            
 Ser Lys Thr Val Lys Arg Leu Ser Lys Leu Arg Glu Tyr Gln Gln Tyr
      50                  55                  60                
 His Ser Ser Leu Thr Cys Val Met Glu Gly Lys Asp Ile Glu Asp Trp
  65                  70                  75                  80
 Ser Cys Cys Pro Thr Pro Trp Thr Ser Phe Gln Ser Ser Cys Tyr Phe
                  85                  90                  95    
 Ile Ser Thr Gly Met Gln Ser Trp Thr Lys Ser Gln Lys Asn Cys Ser
             100                 105                 110        
 Val Met Gly Ala Asp Leu Val Val Ile Asn Thr Thr Glu Glu His Asp
         115                 120                 125            
 Phe Ile Ile His Asn Leu Lys Arg Asn Ser Ser Tyr Phe Leu Gly Leu
     130                 135                 140                
 Ser His Pro Arg Gly Arg Arg His Trp Gln Trp Val Asp His Thr Pro
 145                 150                 155                 160
 Tyr Asn Glu Asn Val Thr Phe Trp His Ser Gly Glu Pro Asn Asn Leu
                 165                 170                 175    
 Asp Glu Arg Cys Ala Ile Ile Asn Phe Arg Ser Ser Gln Glu Trp Gly
             180                 185                 190        
 Trp Asn Asp Ile His Cys His Val Pro His Lys Ser Ile Cys Glu Met
         195                 200                 205            
 Lys Lys Ile Tyr Ile Tyr Met Lys Tyr Ser Pro Trp Lys Cys Val Trp
     210                 215                 220                
 Val Gly Ile His Arg Cys Arg Lys Leu Asn
 225                 230                



      <210> 1097
      <211> 213
      <212> PRT
      <213> Homo sapiens


      <400> 1097
 Met Val Pro Glu Glu Glu Pro Gln Asp Arg Glu Lys Gly Leu Trp Trp
   1               5                  10                  15    
 Phe Gln Leu Lys Val Trp Ser Met Ala Val Val Ser Ile Leu Leu Leu
              20                  25                  30        
 Ser Val Cys Phe Thr Val Ser Ser Val Val Pro His Asn Phe Met Tyr
          35                  40                  45            
 Ser Lys Thr Val Lys Arg Leu Ser Lys Leu Arg Glu Tyr Gln Gln Tyr
      50                  55                  60                
 His Ser Ser Leu Thr Cys Val Met Glu Gly Lys Asp Ile Glu Asp Trp
  65                  70                  75                  80
 Ser Cys Cys Pro Thr Pro Trp Thr Ser Phe Gln Ser Ser Cys Tyr Phe
                  85                  90                  95    
 Ile Ser Thr Gly Met Gln Ser Trp Thr Lys Ser Gln Lys Asn Cys Ser
             100                 105                 110        
 Val Met Gly Ala Asp Leu Val Val Ile Asn Thr Arg Glu Glu Gln Asp
         115                 120                 125            
 Phe Ile Ile Gln Asn Leu Lys Arg Asn Ser Ser Tyr Phe Leu Gly Leu
     130                 135                 140                
 Ser Asp Pro Gly Gly Arg Arg His Trp Gln Trp Val Asp Gln Thr Pro
 145                 150                 155                 160
 Tyr Asn Glu Asn Val Thr Phe Trp His Ser Gly Glu Pro Asn Asn Leu
                 165                 170                 175    
 Asp Glu Arg Cys Ala Ile Ile Asn Phe Arg Ser Ser Glu Glu Trp Gly
             180                 185                 190        
 Trp Asn Asp Ile His Cys His Val Pro Gln Lys Ser Ile Cys Lys Met
         195                 200                 205            
 Lys Lys Ile Tyr Ile
     210            



      <210> 1098
      <211> 312
      <212> PRT
      <213> Homo sapiens


      <400> 1098
 Met Glu Ala Glu Asn Leu Thr Glu Leu Ser Lys Phe Leu Leu Leu Gly
   1               5                  10                  15    
 Leu Ser Asp Asp Pro Glu Leu Gln Pro Val Leu Phe Gly Leu Phe Leu
              20                  25                  30        
 Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala
          35                  40                  45            
 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser
      50                  55                  60                
 Asn Leu Ser Phe Val Asp Ile Cys Phe Ile Ser Thr Thr Val Pro Lys
  65                  70                  75                  80
 Met Leu Val Ser Ile Gln Ala Arg Ser Lys Asp Ile Ser Tyr Met Gly
                  85                  90                  95    
 Cys Leu Thr Gln Val Tyr Phe Leu Met Met Phe Ala Gly Met Asp Thr
             100                 105                 110        
 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His
         115                 120                 125            
 Pro Leu His Tyr Thr Val Ile Met Asn Pro Cys Leu Cys Gly Leu Leu
     130                 135                 140                
 Val Leu Ala Ser Trp Phe Ile Ile Phe Trp Phe Ser Leu Val His Ile
 145                 150                 155                 160
 Leu Leu Met Lys Arg Leu Thr Phe Ser Thr Gly Thr Glu Ile Pro His
                 165                 170                 175    
 Phe Phe Cys Glu Pro Ala Gln Val Leu Lys Val Ala Cys Ser Asn Thr
             180                 185                 190        
 Leu Leu Asn Asn Ile Val Leu Tyr Val Ala Thr Ala Leu Leu Gly Val
         195                 200                 205            
 Phe Pro Val Ala Gly Ile Leu Phe Ser Tyr Ser Gln Ile Val Ser Ser
     210                 215                 220                
 Leu Met Gly Met Ser Ser Thr Lys Gly Lys Tyr Lys Ala Phe Ser Thr
 225                 230                 235                 240
 Cys Gly Ser His Leu Cys Val Val Ser Leu Phe Tyr Gly Thr Gly Leu
                 245                 250                 255    
 Gly Val Tyr Leu Ser Ser Ala Val Thr His Ser Ser Gln Ser Ser Ser
             260                 265                 270        
 Thr Ala Ser Val Met Tyr Ala Met Val Thr Pro Met Leu Asn Pro Phe
         275                 280                 285            
 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Glu Arg Leu
     290                 295                 300                
 Leu Ser Arg Ala Asp Ser Cys Pro
 305                 310        



      <210> 1099
      <211> 642
      <212> PRT
      <213> Homo sapiens


      <400> 1099
 Met Thr Thr Pro Leu Pro Ala His Phe Thr Thr Ser Gly Arg Ile Ala
   1               5                  10                  15    
 Glu Ser Thr Thr Phe Tyr Ile Ser Pro Gly Ser Met Glu Thr Thr Leu
              20                  25                  30        
 Ala Ser Thr Thr Thr Thr Pro Gly Leu Ser Ala Lys Ser Thr Ile Leu
          35                  40                  45            
 Tyr Ser Ser Ser Arg Ser Pro Asp Gln Thr Leu Ser Pro Ala Ser Met
      50                  55                  60                
 Arg Ser Ser Ser Ile Ser Gly Glu Pro Thr Ser Leu Tyr Ser Gln Ala
  65                  70                  75                  80
 Glu Ser Thr His Thr Thr Ala Phe Pro Ala Ser Thr Thr Thr Ser Gly
                  85                  90                  95    
 Leu Ser Gln Glu Ser Thr Thr Phe His Ser Lys Pro Gly Ser Thr Glu
             100                 105                 110        
 Thr Thr Leu Ser Pro Gly Ser Ile Thr Thr Ser Ser Phe Ala Gln Glu
         115                 120                 125            
 Phe Thr Thr Pro His Ser Gln Pro Gly Ser Ala Leu Ser Thr Val Ser
     130                 135                 140                
 Pro Ala Ser Thr Thr Val Pro Gly Leu Ser Glu Glu Ser Thr Thr Phe
 145                 150                 155                 160
 Tyr Ser Ser Pro Gly Ser Thr Glu Thr Thr Ala Phe Ser His Ser Asn
                 165                 170                 175    
 Thr Met Ser Ile His Ser Gln Gln Ser Thr Pro Phe Pro Asp Ser Pro
             180                 185                 190        
 Gly Phe Thr His Thr Val Leu Pro Ala Thr Leu Thr Thr Thr Asp Ile
         195                 200                 205            
 Gly Gln Glu Ser Thr Ala Phe His Ser Ser Ser Asp Ala Thr Gly Thr
     210                 215                 220                
 Thr Pro Leu Pro Ala Arg Ser Thr Ala Ser Asp Leu Val Gly Glu Pro
 225                 230                 235                 240
 Thr Thr Phe Tyr Ile Ser Pro Ser Pro Thr Tyr Thr Thr Leu Phe Pro
                 245                 250                 255    
 Ala Ser Ser Ser Thr Ser Gly Leu Thr Glu Glu Ser Thr Thr Phe His
             260                 265                 270        
 Thr Ser Pro Ser Phe Thr Ser Thr Ile Val Ser Thr Glu Ser Leu Glu
         275                 280                 285            
 Thr Leu Ala Pro Gly Leu Cys Gln Glu Gly Gln Ile Trp Asn Gly Lys
     290                 295                 300                
 Gln Cys Val Cys Pro Gln Gly Tyr Val Gly Tyr Gln Cys Leu Ser Pro
 305                 310                 315                 320
 Leu Glu Ser Phe Pro Val Glu Thr Pro Glu Lys Leu Asn Ala Thr Leu
                 325                 330                 335    
 Gly Met Thr Val Lys Val Thr Tyr Arg Asn Phe Thr Glu Lys Met Asn
             340                 345                 350        
 Asp Ala Ser Ser Gln Glu Tyr Gln Asn Phe Ser Thr Leu Phe Lys Asn
         355                 360                 365            
 Arg Met Asp Val Val Leu Lys Gly Asp Asn Leu Pro Gln Tyr Arg Gly
     370                 375                 380                
 Val Asn Ile Arg Arg Leu Leu Asn Gly Ser Ile Val Val Lys Asn Asp
 385                 390                 395                 400
 Val Ile Leu Glu Ala Asp Tyr Thr Leu Glu Tyr Glu Glu Leu Phe Glu
                 405                 410                 415    
 Asn Leu Ala Glu Ile Val Lys Ala Lys Ile Met Asn Glu Thr Arg Thr
             420                 425                 430        
 Thr Leu Leu Asp Pro Asp Ser Cys Arg Lys Ala Ile Leu Cys Tyr Ser
         435                 440                 445            
 Glu Glu Asp Thr Phe Val Asp Ser Ser Val Thr Pro Gly Phe Asp Phe
     450                 455                 460                
 Gln Glu Gln Cys Thr Gln Lys Ala Ala Glu Gly Tyr Thr Gln Phe Tyr
 465                 470                 475                 480
 Tyr Val Asp Val Leu Asp Gly Lys Leu Ala Cys Val Asn Lys Cys Thr
                 485                 490                 495    
 Lys Gly Thr Lys Ser Gln Met Asn Cys Asn Leu Gly Thr Cys Gln Leu
             500                 505                 510        
 Gln Arg Ser Gly Pro Arg Cys Leu Cys Pro Asn Thr Asn Thr His Trp
         515                 520                 525            
 Tyr Trp Gly Glu Thr Cys Glu Phe Asn Ile Ala Lys Ser Leu Val Tyr
     530                 535                 540                
 Gly Ile Val Gly Ala Val Met Ala Val Leu Leu Leu Ala Leu Ile Ile
 545                 550                 555                 560
 Leu Ile Ile Leu Phe Ser Leu Ser Gln Arg Lys Arg His Arg Glu Gln
                 565                 570                 575    
 Tyr Asp Val Pro Gln Glu Trp Arg Lys Glu Gly Thr Pro Gly Ile Phe
             580                 585                 590        
 Gln Lys Thr Ala Ile Trp Lys Asp Gln Asn Leu Arg Glu Ser Arg Phe
         595                 600                 605            
 Gly Leu Glu Asn Ala Tyr Asn Asn Phe Arg Pro Thr Leu Glu Thr Val
     610                 615                 620                
 Asp Ser Gly Thr Glu Leu His Ile Gln Arg Pro Glu Met Val Ala Ser
 625                 630                 635                 640
 Thr Val
        



      <210> 1100
      <211> 425
      <212> PRT
      <213> Homo sapiens


      <400> 1100
 Met Ala Leu Thr Gly Tyr Ser Trp Leu Leu Leu Ser Ala Thr Phe Leu
   1               5                  10                  15    
 Asn Val Gly Ala Glu Ile Ser Ile Thr Leu Glu Pro Ala Gln Pro Ser
              20                  25                  30        
 Glu Gly Asp Asn Val Thr Leu Val Val His Gly Leu Ser Gly Glu Leu
          35                  40                  45            
 Leu Ala Tyr Ser Trp Tyr Ala Gly Pro Thr Leu Ser Val Ser Tyr Leu
      50                  55                  60                
 Val Ala Ser Tyr Ile Val Ser Thr Gly Asp Glu Thr Pro Gly Pro Ala
  65                  70                  75                  80
 His Thr Gly Arg Glu Ala Val Arg Pro Asp Gly Ser Leu Asp Ile Gln
                  85                  90                  95    
 Gly Ile Leu Pro Arg His Ser Gly Thr Tyr Ile Leu Gln Thr Phe Asn
             100                 105                 110        
 Arg Gln Leu Gln Thr Glu Val Gly Tyr Gly His Val Gln Val His Glu
         115                 120                 125            
 Ile Leu Ala Gln Pro Thr Val Leu Ala Asn Ser Thr Ala Leu Val Glu
     130                 135                 140                
 Arg Arg Asp Thr Leu Arg Leu Met Cys Ser Ser Pro Ser Pro Thr Ala
 145                 150                 155                 160
 Glu Val Arg Trp Phe Phe Asn Gly Gly Ala Leu Pro Val Ala Leu Arg
                 165                 170                 175    
 Leu Gly Leu Phe Pro Asp Gly Arg Val Leu Ala Arg His Gly Ile Arg
             180                 185                 190        
 Arg Glu Glu Ala Gly Ala Tyr Gln Cys Glu Val Trp Asn Pro Val Ser
         195                 200                 205            
 Val Ser Arg Ser Glu Pro Ile Asn Leu Thr Val Tyr Phe Gly Pro Glu
     210                 215                 220                
 Arg Val Ala Ile Leu Gln Asp Ser Thr Thr Arg Thr Gly Cys Thr Ile
 225                 230                 235                 240
 Lys Val Asp Phe Asn Thr Ser Leu Thr Leu Trp Cys Val Ser Arg Ser
                 245                 250                 255    
 Cys Pro Glu Pro Glu Tyr Val Trp Thr Phe Asn Gly Gln Ala Leu Lys
             260                 265                 270        
 Asn Gly Gln Asp His Leu Asn Ile Ser Ser Met Thr Ala Ala Gln Glu
         275                 280                 285            
 Gly Thr Tyr Thr Cys Ile Ala Lys Asn Thr Lys Thr Leu Leu Ser Gly
     290                 295                 300                
 Ser Ala Ser Val Val Val Lys Leu Ser Ala Ala Ala Val Ala Thr Met
 305                 310                 315                 320
 Ile Val Pro Val Pro Thr Lys Pro Thr Glu Gly Gln Asp Val Thr Leu
                 325                 330                 335    
 Thr Val Gln Gly Tyr Pro Lys Asp Leu Leu Val Tyr Ala Trp Tyr Arg
             340                 345                 350        
 Gly Pro Ala Ser Glu Pro Asn Arg Leu Leu Ser Gln Leu Pro Ser Gly
         355                 360                 365            
 Thr Trp Ile Ala Gly Pro Ala His Thr Gly Arg Glu Val Gly Phe Pro
     370                 375                 380                
 Asn Cys Ser Leu Leu Val Gln Lys Leu Asn Leu Thr Asp Thr Gly Arg
 385                 390                 395                 400
 Tyr Thr Leu Lys Thr Val Thr Val Gln Gly Lys Thr Glu Thr Leu Glu
                 405                 410                 415    
 Val Glu Leu Gln Val Ala Pro Leu Gly
             420                 425



      <210> 1101
      <211> 1463
      <212> PRT
      <213> Homo sapiens


      <400> 1101
 Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly
   1               5                  10                  15    
 Trp Cys Leu Pro Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe Lys
              20                  25                  30        
 Ser Thr Val Arg Cys Met His Leu Met Leu Asp His Ile Pro Gln Val
          35                  40                  45            
 Pro Gln Gln Thr Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu
      50                  55                  60                
 Ile Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu Leu
  65                  70                  75                  80
 Leu Asn Asn Asn His Ile Arg Lys Ile Ser Arg Asn Ala Phe Glu Gly
                  85                  90                  95    
 Leu Glu Asn Leu Leu Tyr Leu Tyr Leu Tyr Lys Asn Glu Ile His Ala
             100                 105                 110        
 Leu Asp Lys Gln Thr Phe Lys Gly Leu Ile Ser Leu Glu His Leu Tyr
         115                 120                 125            
 Ile His Phe Asn Gln Leu Glu Met Leu Gln Pro Glu Thr Phe Gly Asp
     130                 135                 140                
 Leu Leu Arg Leu Glu Arg Leu Phe Leu His Asn Asn Lys Leu Ser Lys
 145                 150                 155                 160
 Ile Pro Ala Gly Ser Phe Ser Asn Leu Asp Ser Leu Lys Arg Leu Arg
                 165                 170                 175    
 Leu Asp Ser Asn Ala Leu Val Cys Asp Cys Asp Leu Met Trp Leu Gly
             180                 185                 190        
 Glu Leu Leu Gln Gly Phe Ala Gln His Gly His Thr Gln Ala Ala Ala
         195                 200                 205            
 Thr Cys Glu Tyr Pro Arg Arg Leu His Gly Arg Ala Val Ala Ser Val
     210                 215                 220                
 Thr Val Glu Glu Phe Asn Cys Gln Ser Pro Arg Ile Thr Phe Glu Pro
 225                 230                 235                 240
 Gln Asp Val Glu Val Pro Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg
                 245                 250                 255    
 Ala Glu Gly Asn Pro Lys Pro Glu Ile Ile Trp Ile His Asn Asn His
             260                 265                 270        
 Ser Leu Asp Leu Glu Asp Asp Thr Arg Leu Asn Val Phe Asp Asp Gly
         275                 280                 285            
 Thr Leu Met Ile Arg Asn Thr Arg Glu Ser Asp Gln Gly Val Tyr Gln
     290                 295                 300                
 Cys Met Ala Arg Asn Ser Ala Gly Glu Ala Lys Thr Gln Ser Ala Met
 305                 310                 315                 320
 Leu Arg Tyr Ser Ser Leu Pro Ala Lys Pro Ser Phe Val Ile Gln Pro
                 325                 330                 335    
 Gln Asp Thr Glu Val Leu Ile Gly Thr Ser Thr Thr Leu Glu Cys Met
             340                 345                 350        
 Ala Thr Gly His Pro His Pro Leu Ile Thr Trp Thr Arg Asp Asn Gly
         355                 360                 365            
 Leu Glu Leu Asp Gly Ser Arg His Val Ala Thr Ser Ser Gly Leu Tyr
     370                 375                 380                
 Leu Gln Asn Ile Thr Gln Arg Asp His Gly Arg Phe Thr Cys His Ala
 385                 390                 395                 400
 Asn Asn Ser His Gly Thr Val Gln Ala Ala Ala Asn Ile Ile Val Gln
                 405                 410                 415    
 Ala Pro Pro Gln Phe Thr Val Thr Pro Lys Asp Gln Val Val Leu Glu
             420                 425                 430        
 Glu His Ala Val Glu Trp Leu Cys Glu Ala Asp Gly Asn Pro Pro Pro
         435                 440                 445            
 Val Ile Val Trp Thr Lys Thr Gly Gly Gln Leu Pro Val Glu Gly Gln
     450                 455                 460                
 His Thr Val Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala Gln
 465                 470                 475                 480
 His Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly Val
                 485                 490                 495    
 Lys Lys Val Ser Val Gln Leu Thr Val Lys Pro Lys Ala Leu Ala Val
             500                 505                 510        
 Phe Thr Gln Leu Pro Gln Asp Thr Ser Val Glu Val Gly Lys Asn Ile
         515                 520                 525            
 Asn Ile Ser Cys His Ala Gln Gly Glu Pro Gln Pro Ile Ile Thr Trp
     530                 535                 540                
 Asn Lys Glu Gly Val Gln Ile Thr Glu Ser Gly Lys Phe His Val Asp
 545                 550                 555                 560
 Asp Glu Gly Thr Leu Thr Ile Tyr Asp Ala Gly Phe Pro Asp Gln Gly
                 565                 570                 575    
 Arg Tyr Glu Cys Val Ala Arg Asn Ser Phe Gly Leu Ala Val Thr Asn
             580                 585                 590        
 Met Phe Leu Thr Val Thr Ala Ile Gln Gly Arg Gln Ala Gly Asp Asp
         595                 600                 605            
 Phe Val Glu Ser Ser Ile Leu Asp Ala Val Gln Arg Val Asp Ser Ala
     610                 615                 620                
 Ile Asn Ser Thr Arg Arg His Leu Phe Ser Gln Lys Pro His Thr Ser
 625                 630                 635                 640
 Ser Asp Leu Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile Val
                 645                 650                 655    
 Glu Met Ala Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu Ile
             660                 665                 670        
 Arg Glu Arg Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys Glu
         675                 680                 685            
 Phe Arg Tyr Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile Ala
     690                 695                 700                
 Asn Leu Ser Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn
 705                 710                 715                 720
 Arg Cys Phe His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn Asn
                 725                 730                 735    
 Leu Gln Gln Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu
             740                 745                 750        
 Leu Gln Pro Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly
         755                 760                 765            
 Leu Pro Val Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val Ala
     770                 775                 780                
 Thr Val Trp Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr Thr
 785                 790                 795                 800
 Arg Met Leu Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp His
                 805                 810                 815    
 Thr Val Pro Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys
             820                 825                 830        
 Ser Ser Val Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr Arg
         835                 840                 845            
 His Ala Asp Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala Arg
     850                 855                 860                
 Ser Ser Pro Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp Ser
 865                 870                 875                 880
 Val Tyr Ala Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly
                 885                 890                 895    
 Ser Asn Val Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp
             900                 905                 910        
 Pro Ser Val Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro Pro
         915                 920                 925            
 Ser Gly Lys Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu Cys
     930                 935                 940                
 Ala Arg Gln Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His Arg
 945                 950                 955                 960
 Ala Asn Glu His Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe Arg
                 965                 970                 975    
 Glu His Asn Arg Val Ala Thr Glu Leu Ser Ala Leu Asn Pro His Trp
             980                 985                 990        
 Glu Gly Asn Thr Val Tyr Gln Glu Ala Arg Lys Ile Val Gly Ala Glu
         995                1000                1005            
 Leu Gln His Ile Thr Tyr Ser His Trp Leu Pro Lys Val Leu Gly Asp
    1010                1015                1020                
 Pro Gly Thr Arg Met Leu Arg Gly Tyr Arg Gly Tyr Asn Pro Asn Val
1025                1030                1035                1040
 Asn Ala Gly Ile Ile Asn Ser Phe Ala Thr Ala Ala Phe Arg Phe Gly
                1045                1050                1055    
 His Thr Leu Ile Asn Pro Ile Leu Tyr Arg Leu Asn Ala Thr Leu Gly
            1060                1065                1070        
 Glu Ile Ser Glu Gly His Leu Pro Phe His Lys Ala Leu Phe Ser Pro
        1075                1080                1085            
 Ser Arg Ile Ile Lys Glu Gly Gly Ile Asp Pro Val Leu Arg Gly Leu
    1090                1095                1100                
 Phe Gly Val Ala Ala Lys Trp Arg Ala Pro Ser Tyr Leu Leu Ser Pro
1105                1110                1115                1120
 Glu Leu Thr Gln Arg Leu Phe Ser Ala Ala Tyr Ser Ala Ala Val Asp
                1125                1130                1135    
 Ser Ala Ala Thr Ile Ile Gln Arg Gly Arg Asp His Gly Ile Pro Pro
            1140                1145                1150        
 Tyr Val Asp Phe Arg Val Phe Cys Asn Leu Thr Ser Val Lys Asn Phe
        1155                1160                1165            
 Glu Asp Leu Gln Asn Glu Ile Lys Asp Ser Glu Ile Arg Gln Lys Leu
    1170                1175                1180                
 Arg Lys Leu Tyr Gly Ser Pro Gly Asp Ile Asp Leu Trp Pro Ala Leu
1185                1190                1195                1200
 Met Val Glu Asp Leu Ile Pro Gly Thr Arg Val Gly Pro Thr Leu Met
                1205                1210                1215    
 Cys Met Phe Val Thr Gln Phe Gln Arg Leu Arg Asp Gly Asp Arg Phe
            1220                1225                1230        
 Trp Tyr Glu Asn Pro Gly Val Phe Thr Pro Ala Gln Leu Thr Gln Leu
        1235                1240                1245            
 Lys Gln Ala Ser Leu Ser Arg Val Leu Cys Asp Asn Gly Asp Ser Ile
    1250                1255                1260                
 Gln Gln Val Gln Ala Asp Val Phe Val Lys Ala Glu Tyr Pro Gln Asp
1265                1270                1275                1280
 Tyr Leu Asn Cys Ser Glu Ile Pro Lys Val Asp Leu Arg Val Trp Gln
                1285                1290                1295    
 Asp Cys Cys Ala Asp Cys Arg Ser Arg Gly Gln Phe Arg Ala Val Thr
            1300                1305                1310        
 Gln Glu Ser Gln Lys Lys Arg Ser Ala Gln Tyr Ser Tyr Pro Val Asp
        1315                1320                1325            
 Lys Asp Met Glu Leu Ser His Leu Arg Ser Arg Gln Gln Asp Lys Ile
    1330                1335                1340                
 Tyr Val Gly Glu Asp Ala Arg Asn Val Thr Val Leu Ala Lys Thr Lys
1345                1350                1355                1360
 Phe Ser Gln Asp Phe Ser Thr Phe Ala Ala Glu Ile Gln Glu Thr Ile
                1365                1370                1375    
 Thr Ala Leu Arg Glu Gln Ile Asn Lys Leu Glu Ala Arg Leu Arg Gln
            1380                1385                1390        
 Ala Gly Cys Thr Asp Val Arg Gly Val Pro Arg Lys Ala Glu Glu Arg
        1395                1400                1405            
 Trp Met Lys Glu Asp Cys Thr His Cys Ile Cys Glu Ser Gly Gln Val
    1410                1415                1420                
 Thr Cys Val Val Glu Ile Cys Pro Pro Ala Pro Cys Pro Ser Pro Glu
1425                1430                1435                1440
 Leu Val Lys Gly Thr Cys Cys Pro Val Cys Arg Asp Arg Gly Met Pro
                1445                1450                1455    
 Ser Asp Ser Pro Glu Lys Arg
            1460            



      <210> 1102
      <211> 1439
      <212> PRT
      <213> Homo sapiens


      <400> 1102
 Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly
   1               5                  10                  15    
 Trp Cys Leu Pro Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe Lys
              20                  25                  30        
 Ser Thr Val Arg Cys Met His Leu Met Leu Asp His Ile Pro Gln Val
          35                  40                  45            
 Pro Gln Gln Thr Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu
      50                  55                  60                
 Ile Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu Tyr
  65                  70                  75                  80
 Leu Tyr Lys Asn Glu Ile His Ala Leu Asp Lys Gln Thr Phe Lys Gly
                  85                  90                  95    
 Leu Ile Ser Leu Glu His Leu Tyr Ile His Phe Asn Gln Leu Glu Met
             100                 105                 110        
 Leu Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg Leu Phe
         115                 120                 125            
 Leu His Asn Asn Lys Leu Ser Lys Ile Pro Ala Gly Ser Phe Ser Asn
     130                 135                 140                
 Leu Asp Ser Leu Lys Arg Leu Arg Leu Asp Ser Asn Ala Leu Val Cys
 145                 150                 155                 160
 Asp Cys Asp Leu Met Trp Leu Gly Glu Leu Leu Gln Gly Phe Ala Gln
                 165                 170                 175    
 His Gly His Thr Gln Ala Ala Ala Thr Cys Glu Tyr Pro Arg Arg Leu
             180                 185                 190        
 His Gly Arg Ala Val Ala Ser Val Thr Val Glu Glu Phe Asn Cys Gln
         195                 200                 205            
 Ser Pro Arg Ile Thr Phe Glu Pro Gln Asp Val Glu Val Pro Ser Gly
     210                 215                 220                
 Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys Pro Glu
 225                 230                 235                 240
 Ile Ile Trp Ile His Asn Asn His Ser Leu Asp Leu Glu Asp Asp Thr
                 245                 250                 255    
 Arg Leu Asn Val Phe Asp Asp Gly Thr Leu Met Ile Arg Asn Thr Arg
             260                 265                 270        
 Glu Ser Asp Gln Gly Val Tyr Gln Cys Met Ala Arg Asn Ser Ala Gly
         275                 280                 285            
 Glu Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu Pro Ala
     290                 295                 300                
 Lys Pro Ser Phe Val Ile Gln Pro Gln Asp Thr Glu Val Leu Ile Gly
 305                 310                 315                 320
 Thr Ser Thr Thr Leu Glu Cys Met Ala Thr Gly His Pro His Pro Leu
                 325                 330                 335    
 Ile Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser Arg His
             340                 345                 350        
 Val Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln Arg Asp
         355                 360                 365            
 His Gly Arg Phe Thr Cys His Ala Asn Asn Ser His Gly Thr Val Gln
     370                 375                 380                
 Ala Ala Ala Asn Ile Ile Val Gln Ala Pro Pro Gln Phe Thr Val Thr
 385                 390                 395                 400
 Pro Lys Asp Gln Val Val Leu Glu Glu His Ala Val Glu Trp Leu Cys
                 405                 410                 415    
 Glu Ala Asp Gly Asn Pro Pro Pro Val Ile Val Trp Thr Lys Thr Gly
             420                 425                 430        
 Gly Gln Leu Pro Val Glu Gly Gln His Thr Val Leu Ser Ser Gly Thr
         435                 440                 445            
 Leu Arg Ile Asp Arg Ala Ala Gln His Asp Gln Gly Gln Tyr Glu Cys
     450                 455                 460                
 Gln Ala Val Ser Ser Leu Gly Val Lys Lys Val Ser Val Gln Leu Thr
 465                 470                 475                 480
 Val Lys Pro Lys Ala Leu Ala Val Phe Thr Gln Leu Pro Gln Asp Thr
                 485                 490                 495    
 Ser Val Glu Val Gly Lys Asn Ile Asn Ile Ser Cys His Ala Gln Gly
             500                 505                 510        
 Glu Pro Gln Pro Ile Ile Thr Trp Asn Lys Glu Gly Val Gln Ile Thr
         515                 520                 525            
 Glu Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr Ile Tyr
     530                 535                 540                
 Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala Arg Asn
 545                 550                 555                 560
 Ser Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr Ala Ile
                 565                 570                 575    
 Gln Gly Arg Gln Ala Gly Asp Asp Phe Val Glu Ser Ser Ile Leu Asp
             580                 585                 590        
 Ala Val Gln Arg Val Asp Ser Ala Ile Asn Ser Thr Arg Arg His Leu
         595                 600                 605            
 Phe Ser Gln Lys Pro His Thr Ser Ser Asp Leu Leu Ala Gln Phe His
     610                 615                 620                
 Tyr Pro Arg Asp Pro Leu Ile Val Glu Met Ala Arg Ala Gly Glu Ile
 625                 630                 635                 640
 Phe Glu His Thr Leu Gln Leu Ile Arg Glu Arg Val Lys Gln Gly Leu
                 645                 650                 655    
 Thr Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr Asn Asp Leu Val Ser
             660                 665                 670        
 Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser Gly Cys Thr Ala Arg
         675                 680                 685            
 Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe His Ala Lys Tyr Arg
     690                 695                 700                
 Ala His Asp Gly Thr Cys Asn Asn Leu Gln Gln Pro Thr Trp Gly Ala
 705                 710                 715                 720
 Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro Ala Tyr Arg Asp Gly
                 725                 730                 735    
 Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro Val Gly Ser Arg Gln Pro
             740                 745                 750        
 Leu Pro Pro Pro Arg Leu Val Ala Thr Val Trp Ala Arg Ala Ala Ala
         755                 760                 765            
 Val Thr Pro Asp His Ser Tyr Thr Arg Met Leu Met His Trp Gly Trp
     770                 775                 780                
 Phe Leu Glu His Asp Leu Asp His Thr Val Pro Ala Leu Ser Thr Ala
 785                 790                 795                 800
 Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser Val Cys Thr Asn Asp Pro
                 805                 810                 815    
 Pro Cys Phe Pro Met Asn Thr Arg His Ala Asp Pro Arg Gly Thr His
             820                 825                 830        
 Ala Pro Cys Met Leu Phe Ala Arg Ser Ser Pro Ala Cys Ala Ser Gly
         835                 840                 845            
 Arg Pro Ser Ala Thr Val Asp Ser Val Tyr Ala Arg Glu Gln Ile Asn
     850                 855                 860                
 Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val Tyr Gly Ser Ser Glu
 865                 870                 875                 880
 Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser Val Pro Arg Gly Leu Leu
                 885                 890                 895    
 Lys Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys Pro Leu Leu Pro Phe
             900                 905                 910        
 Ser Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln Glu Gln Glu Ser Pro
         915                 920                 925            
 Cys Phe Leu Ala Gly Asp His Arg Ala Asn Glu His Leu Ala Leu Ala
     930                 935                 940                
 Ala Met His Thr Leu Trp Phe Arg Glu His Asn Arg Val Ala Thr Glu
 945                 950                 955                 960
 Leu Ser Ala Leu Asn Pro His Trp Glu Gly Asn Thr Val Tyr Gln Glu
                 965                 970                 975    
 Ala Arg Lys Ile Val Gly Ala Glu Leu Gln His Ile Thr Tyr Ser His
             980                 985                 990        
 Trp Leu Pro Lys Val Leu Gly Asp Pro Gly Thr Arg Met Leu Arg Gly
         995                1000                1005            
 Tyr Arg Gly Tyr Asn Pro Asn Val Asn Ala Gly Ile Ile Asn Ser Phe
    1010                1015                1020                
 Ala Thr Ala Ala Phe Arg Phe Gly His Thr Leu Ile Asn Pro Ile Leu
1025                1030                1035                1040
 Tyr Arg Leu Asn Ala Thr Leu Gly Glu Ile Ser Glu Gly His Leu Pro
                1045                1050                1055    
 Phe His Lys Ala Leu Phe Ser Pro Ser Arg Ile Ile Lys Glu Gly Gly
            1060                1065                1070        
 Ile Asp Pro Val Leu Arg Gly Leu Phe Gly Val Ala Ala Lys Trp Arg
        1075                1080                1085            
 Ala Pro Ser Tyr Leu Leu Ser Pro Glu Leu Thr Gln Arg Leu Phe Ser
    1090                1095                1100                
 Ala Ala Tyr Ser Ala Ala Val Asp Ser Ala Ala Thr Ile Ile Gln Arg
1105                1110                1115                1120
 Gly Arg Asp His Gly Ile Pro Pro Tyr Val Asp Phe Arg Val Phe Cys
                1125                1130                1135    
 Asn Leu Thr Ser Val Lys Asn Phe Glu Asp Leu Gln Asn Glu Ile Lys
            1140                1145                1150        
 Asp Ser Glu Ile Arg Gln Lys Leu Arg Lys Leu Tyr Gly Ser Pro Gly
        1155                1160                1165            
 Asp Ile Asp Leu Trp Pro Ala Leu Met Val Glu Asp Leu Ile Pro Gly
    1170                1175                1180                
 Thr Arg Val Gly Pro Thr Leu Met Cys Met Phe Val Thr Gln Phe Gln
1185                1190                1195                1200
 Arg Leu Arg Asp Gly Asp Arg Phe Trp Tyr Glu Asn Pro Gly Val Phe
                1205                1210                1215    
 Thr Pro Ala Gln Leu Thr Gln Leu Lys Gln Ala Ser Leu Ser Arg Val
            1220                1225                1230        
 Leu Cys Asp Asn Gly Asp Ser Ile Gln Gln Val Gln Ala Asp Val Phe
        1235                1240                1245            
 Val Lys Ala Glu Tyr Pro Gln Asp Tyr Leu Asn Cys Ser Glu Ile Pro
    1250                1255                1260                
 Lys Val Asp Leu Arg Val Trp Gln Asp Cys Cys Ala Asp Cys Arg Ser
1265                1270                1275                1280
 Arg Gly Gln Phe Arg Ala Val Thr Gln Glu Ser Gln Lys Lys Arg Ser
                1285                1290                1295    
 Ala Gln Tyr Ser Tyr Pro Val Asp Lys Asp Met Glu Leu Ser His Leu
            1300                1305                1310        
 Arg Ser Arg Gln Gln Asp Lys Ile Tyr Val Gly Glu Asp Ala Arg Asn
        1315                1320                1325            
 Val Thr Val Leu Ala Lys Thr Lys Phe Ser Gln Asp Phe Ser Thr Phe
    1330                1335                1340                
 Ala Ala Glu Ile Gln Glu Thr Ile Thr Ala Leu Arg Glu Gln Ile Asn
1345                1350                1355                1360
 Lys Leu Glu Ala Arg Leu Arg Gln Ala Gly Cys Thr Asp Val Arg Gly
                1365                1370                1375    
 Val Pro Arg Lys Ala Glu Glu Arg Trp Met Lys Glu Asp Cys Thr His
            1380                1385                1390        
 Cys Ile Cys Glu Ser Gly Gln Val Thr Cys Val Val Glu Ile Cys Pro
        1395                1400                1405            
 Pro Ala Pro Cys Pro Ser Pro Glu Leu Val Lys Gly Thr Cys Cys Pro
    1410                1415                1420                
 Val Cys Arg Asp Arg Gly Met Pro Ser Asp Ser Pro Glu Lys Arg
1425                1430                1435                



      <210> 1103
      <211> 1198
      <212> PRT
      <213> Homo sapiens


      <400> 1103
 Met Lys Pro Ser Thr Phe Ile Asn Arg Ser Asn Ser Cys Gln Lys Thr
   1               5                  10                  15    
 Leu Ile Pro Gly Val Cys Tyr Ser Gly Gln Trp Gln Pro Glu Pro Gly
              20                  25                  30        
 Pro Arg Ser Leu Gln Gln Ser Arg Leu His His His Cys Ser Gln Ile
          35                  40                  45            
 Gly Gly Val Gly Ser Ala Asn Ser Ser Ala Asp Ser Thr Ile Ser Val
      50                  55                  60                
 Ile Ser Gly Ser Leu Ser His Ser Glu Pro Ser His Gly Leu Ala Asp
  65                  70                  75                  80
 Arg Val Ile Asn Cys Arg Glu Val Leu Glu Ala Phe Asn Leu Leu Val
                  85                  90                  95    
 Leu Gln Val Ser Ser Phe Pro Tyr Thr Leu Gln Thr Gln Gln Ser Arg
             100                 105                 110        
 Ile Ser Ser Ser Asn Glu Val His Trp Ile Gln Leu Asp Thr Gly Glu
         115                 120                 125            
 Asp Val Gly Cys Glu Glu Lys Leu Tyr Phe Gly Leu Ser Glu Tyr Ser
     130                 135                 140                
 Lys Ser Leu Gln Trp Gly Ile Thr Ser Pro Leu Leu Arg Cys Asp Glu
 145                 150                 155                 160
 Thr Phe Glu Lys Met Val Asn Thr Leu Leu Glu Arg Tyr Pro Arg Leu
                 165                 170                 175    
 His Ser Met Val Val Arg Cys Tyr Leu Leu Ile Gln Gln Tyr Ser Glu
             180                 185                 190        
 Ala Leu Met Ala Leu Thr Thr Met Ala Ser Leu Arg Asp His Ser Thr
         195                 200                 205            
 Pro Glu Thr Leu Ser Ile Met Asp Asp Leu Ile Ser Ser Pro Gly Lys
     210                 215                 220                
 Asn Lys Ser Gly Arg Gly His Met Leu Ile Ile Arg Val Pro Ser Val
 225                 230                 235                 240
 Gln Leu Ala Met Leu Ala Lys Glu Arg Leu Gln Glu Val Arg Asp Lys
                 245                 250                 255    
 Leu Gly Leu Gln Tyr Arg Phe Glu Ile Ile Leu Gly Asn Pro Ala Thr
             260                 265                 270        
 Glu Leu Ser Val Ala Thr His Phe Val Ala Arg Leu Lys Ser Trp Arg
         275                 280                 285            
 Gly Asn Glu Pro Glu Glu Trp Ile Pro Arg Thr Tyr Gln Asp Leu Asp
     290                 295                 300                
 Gly Leu Pro Cys Ile Val Ile Leu Thr Gly Lys Asp Pro Leu Gly Glu
 305                 310                 315                 320
 Thr Phe Pro Arg Ser Leu Lys Tyr Cys Asp Leu Arg Leu Ile Asp Ser
                 325                 330                 335    
 Ser Tyr Leu Thr Arg Thr Ala Leu Glu Gln Glu Val Gly Leu Ala Cys
             340                 345                 350        
 Cys Tyr Val Ser Lys Glu Val Ile Arg Gly Pro Thr Val Ala Leu Asp
         355                 360                 365            
 Leu Ser Gly Lys Glu Gln Glu Arg Ala Ala Val Ser Glu Asn Asp Ser
     370                 375                 380                
 Asp Glu Leu Leu Ile Asp Leu Glu Arg Pro Gln Ser Asn Ser Ser Ala
 385                 390                 395                 400
 Val Thr Gly Thr Ser Gly Ser Ile Met Glu Asn Gly Val Ser Ser Ser
                 405                 410                 415    
 Asn Thr Ala Asp Lys Ser Gln Lys Gln Ser Leu Thr Pro Ser Phe Gln
             420                 425                 430        
 Ser Pro Ala Thr Ser Leu Gly Leu Asp Glu Gly Val Ser Ala Ser Ser
         435                 440                 445            
 Ala Gly Ala Gly Ala Gly Glu Thr Leu Lys Gln Glu Cys Asp Ser Leu
     450                 455                 460                
 Gly Pro Gln Met Ala Ser Ser Thr Thr Ser Lys Pro Ser Ser Ser Ser
 465                 470                 475                 480
 Ser Gly Pro Arg Thr Leu Pro Trp Pro Gly Gln Pro Ile Arg Gly Cys
                 485                 490                 495    
 Arg Gly Pro Gln Ala Ala Leu Pro Pro Val Val Ile Leu Ser Lys Ala
             500                 505                 510        
 Ala Tyr Ser Leu Leu Gly Ser Gln Lys Ser Gly Lys Leu Pro Ser Ser
         515                 520                 525            
 Ser Ser Leu Leu Pro His Ala Asp Val Ala Trp Val Ser Ser Leu Arg
     530                 535                 540                
 Pro Leu Leu Asn Lys Asp Met Ser Ser Glu Glu Gln Ser Leu Tyr Tyr
 545                 550                 555                 560
 Arg Gln Trp Thr Leu Ala Arg Gln His His Ala Asp Tyr Ser Asn Gln
                 565                 570                 575    
 Leu Asp Pro Ala Ser Gly Thr Arg Asn Phe Leu Pro Arg Arg Leu Leu
             580                 585                 590        
 Leu Thr Gly Pro Pro Gln Val Gly Lys Thr Gly Ser Tyr Leu Gln Phe
         595                 600                 605            
 Leu Arg Ile Leu Phe Arg Met Leu Ile Arg Leu Leu Glu Val Asp Val
     610                 615                 620                
 Tyr Asp Glu Glu Glu Ile Asn Thr Asp His Asn Glu Ser Ser Glu Val
 625                 630                 635                 640
 Ser Gln Ser Glu Gly Glu Pro Trp Pro Asp Ile Glu Ser Phe Ser Lys
                 645                 650                 655    
 Met Pro Phe Asp Val Ser Val His Asp Pro Lys Tyr Ser Leu Met Ser
             660                 665                 670        
 Leu Val Tyr Thr Glu Lys Leu Ala Gly Val Lys Gln Glu Val Ile Lys
         675                 680                 685            
 Glu Ser Lys Val Glu Glu Pro Arg Lys Arg Glu Thr Val Ser Ile Met
     690                 695                 700                
 Leu Thr Lys Tyr Ala Ala Tyr Asn Thr Phe His His Cys Glu Gln Cys
 705                 710                 715                 720
 Arg Gln Tyr Met Asp Phe Thr Ser Ala Ser Gln Met Ser Asp Ser Thr
                 725                 730                 735    
 Leu His Ala Phe Thr Phe Ser Ser Ser Met Leu Gly Glu Glu Val Gln
             740                 745                 750        
 Leu Tyr Phe Ile Ile Pro Lys Ser Lys Glu Ser His Phe Val Phe Ser
         755                 760                 765            
 Lys Gln Gly Lys His Leu Glu Ser Met Arg Leu Pro Leu Val Ser Asp
     770                 775                 780                
 Lys Asn Leu Asn Ala Val Lys Ser Pro Ile Phe Thr Pro Ser Ser Gly
 785                 790                 795                 800
 Arg His Glu His Gly Leu Leu Asn Leu Phe His Ala Met Glu Gly Ile
                 805                 810                 815    
 Ser His Leu His Leu Leu Val Val Lys Glu Tyr Glu Met Pro Leu Tyr
             820                 825                 830        
 Arg Lys Tyr Trp Pro Asn His Ile Met Leu Val Leu Pro Gly Met Phe
         835                 840                 845            
 Asn Asn Ala Gly Val Gly Ala Ala Arg Phe Leu Ile Lys Glu Leu Ser
     850                 855                 860                
 Tyr His Asn Leu Glu Leu Glu Arg Asn Arg Leu Glu Glu Leu Gly Ile
 865                 870                 875                 880
 Lys Arg Gln Cys Val Trp Pro Phe Ile Val Met Met Asp Asp Ser Cys
                 885                 890                 895    
 Val Leu Trp Asn Ile His Ser Val Gln Glu Pro Ser Ser Gln Pro Met
             900                 905                 910        
 Glu Val Gly Val Ser Ser Lys Asn Val Ser Leu Lys Thr Val Leu Gln
         915                 920                 925            
 His Ile Glu Ala Thr Pro Lys Ile Val His Tyr Ala Ile Leu Gly Ile
     930                 935                 940                
 Gln Lys Trp Ser Ser Lys Leu Thr Ser Gln Ser Leu Lys Ala Pro Phe
 945                 950                 955                 960
 Ser Arg Cys His Val His Asp Phe Ile Leu Leu Asn Thr Asp Leu Thr
                 965                 970                 975    
 Gln Asn Val Gln Tyr Asp Phe Asn Arg Tyr Phe Cys Glu Asp Ala Asp
             980                 985                 990        
 Phe Asn Leu Arg Thr Asn Ser Ser Gly Leu Leu Ile Cys Arg Phe Asn
         995                1000                1005            
 Asn Phe Ser Leu Met Lys Lys His Val Gln Val Gly Gly Gln Arg Asp
    1010                1015                1020                
 Phe Ile Ile Lys Pro Lys Ile Met Val Ser Glu Ser Leu Ala Pro Ile
1025                1030                1035                1040
 Leu Pro Leu Gln Tyr Ile Cys Ala Pro Asp Ser Glu His Thr Leu Leu
                1045                1050                1055    
 Ala Ala Pro Ala Gln Phe Leu Leu Glu Lys Phe Leu Gln His Ala Ser
            1060                1065                1070        
 Tyr Lys Leu Phe Pro Lys Ala Ile His Asn Phe Arg Ser Pro Val Leu
        1075                1080                1085            
 Ala Ile Asp Cys Tyr Leu Asn Ile Gly Pro Glu Val Ala Ile Cys Tyr
    1090                1095                1100                
 Ile Ser Ser Arg Pro His Ser Ser Asn Val Asn Cys Glu Gly Val Phe
1105                1110                1115                1120
 Phe Ser Gly Leu Leu Leu Tyr Leu Cys Asp Ser Phe Val Gly Ala Asp
                1125                1130                1135    
 Leu Lys Lys Phe Lys Phe Leu Lys Gly Ala Thr Leu Cys Val Ile Cys
            1140                1145                1150        
 Gln Asp Arg Ser Ser Leu Arg Gln Thr Ile Val Arg Leu Glu Leu Glu
        1155                1160                1165            
 Asp Glu Trp Gln Phe Arg Leu Arg Asp Glu Phe Gln Thr Ala Asn Ser
    1170                1175                1180                
 Ser Asp Asp Lys Pro Leu Tyr Phe Leu Thr Gly Arg His Val
1185                1190                1195            



      <210> 1104
      <211> 408
      <212> PRT
      <213> Homo sapiens


      <400> 1104
 Met Ser Leu Asn Glu Leu Glu Ile Leu Arg Asn Ser Ala Val Ser Gln
   1               5                  10                  15    
 Glu Arg Lys Leu Gln Asn Ser Met Leu Lys His Ala Asn Asn Val Thr
              20                  25                  30        
 Ile Arg Glu Ser Met Gln Asn Asp Val Arg Lys Ile Val Ser Lys Leu
          35                  40                  45            
 Gln Glu Met Lys Glu Lys Lys Glu Ala Gln Leu Asn Asn Ile Asp Arg
      50                  55                  60                
 Leu Ala Asn Thr Ile Thr Met Ile Glu Glu Glu Met Val Gln Leu Arg
  65                  70                  75                  80
 Lys Arg Tyr Glu Lys Ala Val Gln His Arg Asn Glu Ser Gly Val Gln
                  85                  90                  95    
 Leu Ile Glu Arg Glu Glu Glu Ile Cys Ile Phe Tyr Glu Lys Ile Asn
             100                 105                 110        
 Ile Gln Glu Lys Met Lys Leu Asn Gly Glu Ile Glu Ile His Leu Leu
         115                 120                 125            
 Glu Glu Lys Ile Gln Phe Leu Lys Met Lys Ile Ala Glu Lys Gln Arg
     130                 135                 140                
 Gln Ile Cys Val Thr Gln Lys Leu Leu Pro Ala Lys Arg Ser Leu Asp
 145                 150                 155                 160
 Ala Asp Leu Ala Val Leu Gln Ile Gln Phe Ser Gln Cys Thr Asp Arg
                 165                 170                 175    
 Ile Lys Asp Leu Glu Lys Gln Phe Val Lys Pro Asp Gly Glu Asn Arg
             180                 185                 190        
 Ala Arg Phe Leu Pro Gly Lys Asp Leu Thr Glu Lys Glu Met Ile Gln
         195                 200                 205            
 Lys Leu Asp Lys Leu Glu Leu Gln Leu Ala Lys Lys Glu Glu Lys Leu
     210                 215                 220                
 Leu Glu Lys Asp Phe Ile Tyr Glu Gln Val Ser Arg Leu Thr Asp Arg
 225                 230                 235                 240
 Leu Cys Ser Lys Thr Gln Gly Cys Lys Gln Asp Thr Leu Leu Leu Ala
                 245                 250                 255    
 Lys Lys Met Asn Gly Tyr Gln Arg Arg Ile Lys Asn Ala Thr Glu Lys
             260                 265                 270        
 Met Met Ala Leu Val Ala Glu Leu Ser Met Lys Gln Ala Leu Thr Ile
         275                 280                 285            
 Glu Leu Gln Lys Glu Val Arg Glu Lys Glu Asp Phe Ile Phe Thr Cys
     290                 295                 300                
 Asn Ser Arg Ile Glu Lys Gly Leu Pro Leu Asn Lys Glu Ile Glu Lys
 305                 310                 315                 320
 Glu Trp Leu Lys Val Leu Arg Asp Glu Glu Met His Ala Leu Ala Ile
                 325                 330                 335    
 Ala Glu Lys Ser Gln Glu Phe Leu Glu Ala Asp Asn Arg Gln Leu Pro
             340                 345                 350        
 Asn Gly Val Tyr Thr Thr Ala Glu Gln Arg Pro Asn Ala Tyr Ile Pro
         355                 360                 365            
 Glu Ala Asp Ala Thr Leu Pro Leu Pro Lys Pro Tyr Gly Ala Leu Ala
     370                 375                 380                
 Pro Phe Lys Pro Ser Glu Pro Gly Ala Asn Met Arg His Ile Arg Lys
 385                 390                 395                 400
 Pro Val Ile Lys Pro Val Glu Ile
                 405            



      <210> 1105
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 1105
 Met Leu Arg Gly Pro Trp Arg Phe Phe Trp Leu Phe Leu Leu Leu Leu
   1               5                  10                  15    
 Leu Pro Gly Ala Pro Asp Pro Arg Val Arg Ser Arg Pro Trp Glu Gly
              20                  25                  30        
 Thr Asp Glu Pro Gly Ser Ala Trp Ala Trp Pro Gly Phe Gln Arg Leu
          35                  40                  45            
 Gln Glu Gln Leu Arg Ala Ala Gly Ala Leu Ser Lys Arg Tyr Trp Thr
      50                  55                  60                
 Leu Phe Ser Cys Gln Val Trp Pro Asp Asp Cys Asp Glu Asp Glu Glu
  65                  70                  75                  80
 Ala Ala Thr Gly Pro Leu Gly Trp Arg Leu Pro Leu Leu Gly Gln Arg
                  85                  90                  95    
 Tyr Leu Asp Leu Leu Thr Thr Trp Tyr Cys Ser Phe Lys Asp Cys Cys
             100                 105                 110        
 Pro Arg Gly Asp Cys Arg Ile Ser Asn Asn Phe Thr Gly Ala Ala Asp
         115                 120                 125            
 Glu Pro Asp Pro Gly Asp Ala Ala Ala Leu Pro Pro Asp Pro Val His
     130                 135                 140                
 Leu Arg
 145    



      <210> 1106
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 1106
 Met Ala Val Val Ile Arg Leu Leu Gly Leu Pro Phe Ile Ala Gly Pro
   1               5                  10                  15    
 Val Asp Ile Arg His Phe Phe Thr Gly Leu Thr Ile Pro Asp Gly Gly
              20                  25                  30        
 Val His Ile Ile Gly Gly Glu Ile Gly Glu Ala Phe Ile Ile Phe Ala
          35                  40                  45            
 Thr Asp Glu Asp Ala Arg Arg Ala Ile Ser Arg Ser Gly Gly Phe Ile
      50                  55                  60                
 Lys Asp Ser Ser Val Glu Leu Phe Leu Ser Ser Lys Ala Glu Met Gln
  65                  70                  75                  80
 Lys Thr Ile Glu Met Lys Arg Thr Asp Arg Val Gly Arg Gly Arg Pro
                  85                  90                  95    
 Gly Ser Gly Thr Ser Gly Val Asp Ser Leu Ser Asn Phe Ile Glu Ser
             100                 105                 110        
 Val Lys Glu Glu Ala Ser Asn Ser Gly Tyr Gly Ser Ser Ile Asn Gln
         115                 120                 125            
 Asp Ala Gly Phe His Thr Asn Gly Thr Gly His Gly Asn Leu Arg Pro
     130                 135                 140                
 Arg Lys Thr Arg Pro Leu Lys Ala Glu Asn Pro Tyr Leu Phe Leu Arg
 145                 150                 155                 160
 Gly Phe Ala Leu Pro Ser Lys
                 165        



      <210> 1107
      <211> 824
      <212> PRT
      <213> Homo sapiens


      <400> 1107
 Met Met Trp Phe Glu Lys Leu Tyr Ala Gly Leu Gln Cys Val Glu Lys
   1               5                  10                  15    
 Tyr Leu Ile Tyr Pro Ala Val Val Leu Asn Ala Leu Thr Val Asp Ala
              20                  25                  30        
 His Thr Val Val Ser His Pro Asp Lys Tyr Cys Phe Tyr Cys Arg Ala
          35                  40                  45            
 Leu Leu Met Thr Val Ala Gly Leu Lys Leu Leu Arg Ser Ala Phe Cys
      50                  55                  60                
 Cys Pro Pro Gln Gln Tyr Leu Thr Leu Ala Phe Thr Val Leu Leu Phe
  65                  70                  75                  80
 His Phe Asp Tyr Pro Arg Leu Ser Gln Gly Phe Leu Leu Asp Tyr Phe
                  85                  90                  95    
 Leu Met Ser Leu Leu Cys Ser Lys Leu Trp Asp Leu Leu Tyr Lys Leu
             100                 105                 110        
 Arg Phe Val Leu Thr Tyr Ile Ala Pro Trp Gln Ile Thr Trp Gly Ser
         115                 120                 125            
 Ala Phe His Ala Phe Ala Gln Pro Phe Ala Val Pro His Ser Ala Met
     130                 135                 140                
 Leu Phe Val Gln Ala Leu Leu Ser Gly Leu Phe Ser Thr Pro Leu Asn
 145                 150                 155                 160
 Pro Leu Leu Gly Ser Ala Val Phe Ile Met Ser Tyr Ala Arg Pro Leu
                 165                 170                 175    
 Lys Phe Trp Glu Arg Asp Tyr Asn Thr Lys Arg Val Asp His Ser Asn
             180                 185                 190        
 Thr Arg Leu Val Thr Gln Leu Asp Arg Asn Pro Gly Ala Asp Asp Asn
         195                 200                 205            
 Asn Leu Asn Ser Ile Phe Tyr Glu His Leu Thr Arg Ser Leu Gln His
     210                 215                 220                
 Thr Leu Cys Gly Asp Leu Val Leu Gly Arg Trp Gly Asn Tyr Gly Pro
 225                 230                 235                 240
 Gly Asp Cys Phe Val Leu Ala Ser Asp Tyr Leu Asn Ala Leu Val His
                 245                 250                 255    
 Leu Ile Glu Val Gly Asn Gly Leu Val Thr Phe Gln Leu Arg Gly Leu
             260                 265                 270        
 Glu Phe Arg Gly Thr Tyr Cys Gln Gln Arg Glu Val Glu Ala Ile Thr
         275                 280                 285            
 Glu Gly Val Glu Glu Asp Glu Gly Cys Cys Cys Cys Glu Pro Gly His
     290                 295                 300                
 Leu Pro Arg Val Leu Ser Phe Asn Ala Ala Phe Gly Gln Arg Trp Leu
 305                 310                 315                 320
 Ala Trp Glu Val Thr Ala Ser Lys Tyr Val Leu Glu Gly Tyr Ser Ile
                 325                 330                 335    
 Ser Asp Asn Asn Ala Ala Ser Met Leu Gln Val Phe Asp Leu Arg Lys
             340                 345                 350        
 Ile Leu Ile Thr Tyr Tyr Val Lys Ser Ile Ile Tyr Tyr Val Ser Arg
         355                 360                 365            
 Ser Pro Lys Leu Glu Val Trp Leu Ser His Glu Gly Ile Thr Ala Ala
     370                 375                 380                
 Leu Arg Pro Val Arg Val Pro Gly Tyr Ala Asp Ser Asp Pro Thr Phe
 385                 390                 395                 400
 Ser Leu Ser Val Asp Glu Asp Tyr Asp Leu Arg Leu Ser Gly Leu Ser
                 405                 410                 415    
 Leu Pro Ser Phe Cys Ala Val His Leu Glu Trp Ile Gln Tyr Cys Ala
             420                 425                 430        
 Ser Arg Arg Ser Gln Pro Val Asp Gln Asp Trp Asn Ser Pro Leu Val
         435                 440                 445            
 Thr Leu Cys Phe Gly Leu Cys Val Leu Gly Arg Arg Ala Leu Gly Thr
     450                 455                 460                
 Ala Ser His Ser Met Ser Ala Ser Leu Glu Pro Phe Leu Tyr Gly Leu
 465                 470                 475                 480
 His Ala Leu Phe Lys Gly Asp Phe Arg Ile Thr Ser Pro Arg Asp Glu
                 485                 490                 495    
 Trp Val Phe Ala Asp Met Asp Leu Leu His Arg Val Val Ala Pro Gly
             500                 505                 510        
 Val Arg Met Ala Leu Lys Leu His Gln Asp His Phe Thr Ser Pro Asp
         515                 520                 525            
 Glu Tyr Glu Glu Pro Ala Ala Leu Tyr Asp Ala Ile Ala Ala Asn Glu
     530                 535                 540                
 Glu Arg Leu Val Ile Ser His Glu Gly Asp Pro Ala Trp Arg Ser Ala
 545                 550                 555                 560
 Ile Leu Ser Asn Thr Pro Ser Leu Leu Ala Leu Arg His Val Leu Asp
                 565                 570                 575    
 Asp Ala Ser Asp Glu Tyr Lys Ile Ile Met Leu Asn Arg Arg His Leu
             580                 585                 590        
 Ser Phe Arg Val Ile Lys Val Asn Arg Glu Cys Val Arg Gly Leu Trp
         595                 600                 605            
 Ala Gly Gln Gln Gln Glu Leu Val Phe Leu Arg Asn Arg Tyr Pro Ile
     610                 615                 620                
 Tyr Val Ser Pro Leu Thr Thr Ser Leu Ala Gly Ser His Pro Gln Leu
 625                 630                 635                 640
 Arg Ala Leu Trp Gly Gly Pro Ile Ser Leu Gly Ala Ile Ala His Trp
                 645                 650                 655    
 Leu Leu Arg Thr Trp Glu Arg Leu His Lys Gly Cys Gly Ala Gly Cys
             660                 665                 670        
 Asn Ser Gly Gly Asn Val Asp Asp Ser Asp Cys Ser Gly Gly Gly Gly
         675                 680                 685            
 Leu Thr Ser Leu Ser Asn Asn Pro Pro Val Ala His Pro Thr Pro Glu
     690                 695                 700                
 Asn Thr Ala Gly Asn Gly Asp Gln Pro Leu Pro Pro Gly Pro Gly Trp
 705                 710                 715                 720
 Gly Pro Arg Ser Ser Leu Ser Gly Ser Gly Asp Gly Arg Pro Pro Pro
                 725                 730                 735    
 Leu Leu Gln Trp Pro Pro Pro Arg Leu Pro Gly Pro Pro Pro Ala Ser
             740                 745                 750        
 Pro Ile Pro Thr Glu Gly Pro Arg Thr Ser Arg Pro Pro Gly Pro Gly
         755                 760                 765            
 Leu Leu Ser Ser Glu Gly Pro Ser Gly Lys Trp Ser Leu Gly Gly Arg
     770                 775                 780                
 Lys Gly Leu Gly Gly Ser Asp Gly Glu Pro Ala Ser Gly Ser Pro Lys
 785                 790                 795                 800
 Gly Gly Thr Pro Lys Ser Gln Ala Pro Leu Asp Ser Ala Gln Leu Ser
                 805                 810                 815    
 Ser Ala Ser Ala Arg Cys Gln His
             820                



      <210> 1108
      <211> 628
      <212> PRT
      <213> Homo sapiens


      <400> 1108
 Met Met Trp Phe Glu Lys Leu Tyr Ala Gly Leu Gln Cys Val Glu Lys
   1               5                  10                  15    
 Tyr Leu Ile Tyr Pro Ala Val Val Leu Asn Ala Leu Thr Val Asp Ala
              20                  25                  30        
 His Thr Val Val Ser His Pro Asp Lys Tyr Cys Phe Tyr Cys Arg Ala
          35                  40                  45            
 Leu Leu Met Thr Val Ala Gly Leu Lys Leu Leu Arg Ser Ala Phe Cys
      50                  55                  60                
 Cys Pro Pro Gln Gln Tyr Leu Thr Leu Ala Phe Thr Val Leu Leu Phe
  65                  70                  75                  80
 His Phe Asp Tyr Pro Arg Leu Ser Gln Gly Phe Leu Leu Asp Tyr Phe
                  85                  90                  95    
 Leu Met Ser Leu Leu Cys Ser Lys Leu Trp Asp Leu Leu Tyr Lys Leu
             100                 105                 110        
 Arg Phe Val Leu Thr Tyr Ile Ala Pro Trp Gln Ile Thr Trp Gly Ser
         115                 120                 125            
 Ala Phe His Ala Phe Ala Gln Pro Phe Ala Val Pro His Ser Ala Met
     130                 135                 140                
 Leu Phe Val Gln Ala Leu Leu Ser Gly Leu Phe Ser Thr Pro Leu Asn
 145                 150                 155                 160
 Pro Leu Leu Gly Ser Ala Val Phe Ile Met Ser Tyr Ala Arg Pro Leu
                 165                 170                 175    
 Lys Phe Trp Glu Arg Asp Tyr Asn Thr Lys Arg Val Asp His Ser Asn
             180                 185                 190        
 Thr Arg Leu Val Thr Gln Leu Asp Arg Asn Pro Gly Ala Asp Asp Asn
         195                 200                 205            
 Asn Leu Asn Ser Ile Phe Tyr Glu His Leu Thr Arg Ser Leu Gln His
     210                 215                 220                
 Thr Leu Cys Gly Asp Leu Val Leu Gly Arg Trp Gly Asn Tyr Gly Pro
 225                 230                 235                 240
 Gly Asp Cys Phe Val Leu Ala Ser Asp Tyr Leu Asn Ala Leu Val His
                 245                 250                 255    
 Leu Ile Glu Val Gly Asn Gly Leu Val Thr Phe Gln Leu Arg Gly Leu
             260                 265                 270        
 Glu Phe Arg Gly Thr Tyr Cys Gln Gln Arg Glu Val Glu Ala Ile Thr
         275                 280                 285            
 Glu Gly Val Glu Glu Asp Glu Gly Cys Cys Cys Cys Glu Pro Gly His
     290                 295                 300                
 Leu Pro Arg Val Leu Ser Phe Asn Ala Ala Phe Gly Gln Arg Trp Leu
 305                 310                 315                 320
 Ala Trp Glu Val Thr Ala Ser Lys Tyr Val Leu Glu Gly Tyr Ser Ile
                 325                 330                 335    
 Ser Asp Asn Asn Ala Ala Ser Met Leu Gln Val Phe Asp Leu Arg Lys
             340                 345                 350        
 Ile Leu Ile Thr Tyr Tyr Val Lys Ser Ile Ile Tyr Tyr Val Ser Arg
         355                 360                 365            
 Ser Pro Lys Leu Glu Val Trp Leu Ser His Glu Gly Ile Thr Ala Ala
     370                 375                 380                
 Leu Arg Pro Val Arg Val Pro Gly Tyr Ala Asp Ser Asp Pro Thr Phe
 385                 390                 395                 400
 Ser Leu Ser Val Asp Glu Asp Tyr Asp Leu Arg Leu Ser Gly Leu Ser
                 405                 410                 415    
 Leu Pro Ser Phe Cys Ala Val His Leu Glu Trp Ile Gln Tyr Cys Ala
             420                 425                 430        
 Ser Arg Arg Ser Gln Pro Val Asp Gln Asp Trp Asn Ser Pro Leu Val
         435                 440                 445            
 Thr Leu Cys Phe Gly Leu Cys Val Leu Gly Arg Arg Ala Leu Gly Thr
     450                 455                 460                
 Ala Ser His Ser Met Ser Ala Ser Leu Glu Pro Phe Leu Tyr Gly Leu
 465                 470                 475                 480
 His Ala Leu Phe Lys Gly Asp Phe Arg Ile Thr Ser Pro Arg Asp Glu
                 485                 490                 495    
 Trp Val Phe Ala Asp Met Asp Leu Leu His Arg Val Val Ala Pro Gly
             500                 505                 510        
 Val Arg Met Ala Leu Lys Leu His Gln Asp His Phe Thr Ser Pro Asp
         515                 520                 525            
 Glu Tyr Glu Glu Pro Ala Ala Leu Tyr Asp Ala Ile Ala Ala Asn Glu
     530                 535                 540                
 Glu Arg Leu Val Ile Ser His Glu Gly Asp Pro Ala Trp Arg Ser Ala
 545                 550                 555                 560
 Ile Leu Ser Asn Thr Pro Ser Leu Leu Ala Leu Arg His Val Leu Asp
                 565                 570                 575    
 Asp Ala Ser Asp Glu Tyr Lys Ile Ile Met Leu Asn Arg Arg His Leu
             580                 585                 590        
 Ser Phe Arg Val Ile Lys Val Gly Pro Ala Pro Pro Ala Leu Ser Pro
         595                 600                 605            
 Arg Gly Gln Pro Gly Trp Phe Cys Lys Ile Leu Gly Trp Cys Thr Val
     610                 615                 620                
 Ile Phe Phe Leu
 625            



      <210> 1109
      <211> 111
      <212> PRT
      <213> Homo sapiens


      <400> 1109
 Met Trp Asp Pro Pro Leu Val Val Pro Arg Phe Pro Arg Pro Ala Leu
   1               5                  10                  15    
 Ala Gln Phe Gln Thr Arg Trp Ala Arg Arg Pro Pro Ala Gly Val Phe
              20                  25                  30        
 Glu Pro Phe Ser Gly Ala Gly Pro Pro Asn Lys Val Phe Phe Leu Arg
          35                  40                  45            
 Leu Cys Val Cys Phe Phe Phe Ala Thr Glu Ser Cys Thr Val Thr Trp
      50                  55                  60                
 Ala Gly Val Gln Trp Cys Asn Leu Ser Ser Leu Gln Pro Leu Pro Ser
  65                  70                  75                  80
 Gly Phe Lys Pro Phe Ser Cys Leu Ser Leu Pro Gly Ser Trp Asp Tyr
                  85                  90                  95    
 Arg His Leu Pro Pro Cys Pro Ala Asn Phe Leu Tyr Cys Phe Phe
             100                 105                 110    



      <210> 1110
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 1110
 Met Val Lys Met Thr Lys Leu Arg Val Val Gln Tyr Tyr Gly Asn Phe
   1               5                  10                  15    
 Ser Arg Ser Ala Lys Arg Arg Arg Leu Arg Leu Leu Glu Glu Gln Arg
              20                  25                  30        
 Gly Ala Leu Tyr Arg Leu Ser Val Leu Thr Leu Gln Pro Ser Asp Gln
          35                  40                  45            
 Gly His Tyr Val Cys Arg Val Gln Glu Ile Ser Arg His Arg Asn Lys
      50                  55                  60                
 Trp Thr Ala Trp Ser Asn Gly Ser Ser Ala Thr Glu Met Arg Val Ile
  65                  70                  75                  80
 Ser Leu Lys Ala Ser Glu Glu Ser Ser Phe Glu Lys Thr Lys Glu Thr
                  85                  90                  95    
 Trp Ala Phe Phe Glu Asp Leu Tyr Val Tyr Ala Val Leu Val Cys Cys
             100                 105                 110        
 Val Gly Ile Leu Ser Ile Leu Leu Phe Met Leu Val Ile Val Trp Gln
         115                 120                 125            
 Ser Val Phe Asn Lys Arg Lys Ser Arg Val Arg His Tyr Leu Val Lys
     130                 135                 140                
 Cys Pro Gln Asn Ser Ser Gly Glu Thr Val Thr Ser Val Thr Arg Leu
 145                 150                 155                 160
 Gly Pro Thr Thr Ala Gln Glu Gly Gln Glu Ala Glu Gly Glu Ala
                 165                 170                 175



      <210> 1111
      <211> 298
      <212> PRT
      <213> Homo sapiens


      <400> 1111
 Met Leu Leu Val Leu Gly Leu Cys Gly Ala Ala Tyr Arg Pro Thr Glu
   1               5                  10                  15    
 Glu Ile Asp Leu Arg Ser Val Gly Trp Gly Asn Ile Phe Gln Leu Pro
              20                  25                  30        
 Phe Lys His Val Arg Asp Tyr Arg Leu Arg His Leu Val Pro Phe Phe
          35                  40                  45            
 Ile Tyr Ser Gly Phe Glu Val Leu Phe Ala Cys Thr Gly Ile Ala Leu
      50                  55                  60                
 Gly Tyr Gly Val Cys Ser Val Gly Leu Glu Arg Leu Ala Tyr Leu Leu
  65                  70                  75                  80
 Val Ala Tyr Ser Leu Gly Ala Ser Ala Ala Ser Leu Leu Gly Leu Leu
                  85                  90                  95    
 Gly Leu Trp Leu Pro Arg Pro Val Pro Leu Val Ala Gly Ala Gly Val
             100                 105                 110        
 His Leu Leu Leu Thr Phe Ile Leu Phe Phe Trp Ala Pro Val Pro Arg
         115                 120                 125            
 Val Leu Gln His Ser Trp Ile Leu Tyr Val Ala Ala Ala Leu Trp Gly
     130                 135                 140                
 Val Gly Ser Ala Leu Asn Lys Thr Gly Leu Ser Thr Leu Leu Gly Ile
 145                 150                 155                 160
 Leu Tyr Glu Asp Lys Glu Arg Gln Asp Phe Ile Phe Thr Ile Tyr His
                 165                 170                 175    
 Trp Trp Gln Ala Val Ala Ile Phe Thr Val Tyr Leu Gly Ser Ser Leu
             180                 185                 190        
 His Met Lys Ala Lys Leu Ala Val Leu Leu Val Thr Leu Val Ala Ala
         195                 200                 205            
 Ala Val Ser Tyr Leu Arg Met Glu Gln Lys Leu Arg Arg Gly Val Ala
     210                 215                 220                
 Pro Arg Gln Pro Arg Ile Pro Arg Pro Gln His Lys Val Arg Gly Tyr
 225                 230                 235                 240
 Arg Tyr Leu Glu Glu Asp Asn Ser Asp Glu Ser Asp Ala Glu Gly Glu
                 245                 250                 255    
 His Gly Asp Gly Ala Glu Glu Glu Ala Pro Pro Ala Gly Pro Arg Pro
             260                 265                 270        
 Gly Pro Glu Pro Ala Gly Leu Gly Arg Arg Pro Cys Pro Tyr Glu Gln
         275                 280                 285            
 Ala Gln Gly Gly Asp Gly Pro Glu Glu Gln
     290                 295            



      <210> 1112
      <211> 459
      <212> PRT
      <213> Homo sapiens


      <400> 1112
 Met Ala Ala Ser Ala Ser Ala Ala Ala Gly Glu Glu Asp Trp Val Leu
   1               5                  10                  15    
 Pro Ser Glu Val Glu Val Leu Glu Ser Ile Tyr Leu Asp Glu Leu Gln
              20                  25                  30        
 Val Ile Lys Gly Asn Gly Arg Thr Ser Pro Trp Glu Ile Tyr Ile Thr
          35                  40                  45            
 Leu His Pro Ala Thr Ala Glu Asp Gln Asp Ser Gln Tyr Val Cys Phe
      50                  55                  60                
 Thr Leu Val Leu Gln Val Pro Ala Glu Tyr Pro His Glu Val Pro Gln
  65                  70                  75                  80
 Ile Ser Ile Arg Asn Pro Arg Gly Leu Ser Asp Glu Gln Ile His Thr
                  85                  90                  95    
 Ile Leu Gln Val Leu Gly His Val Ala Lys Ala Gly Leu Gly Thr Ala
             100                 105                 110        
 Met Leu Tyr Glu Leu Ile Glu Lys Gly Lys Glu Ile Leu Thr Asp Asn
         115                 120                 125            
 Asn Ile Pro His Gly Gln Cys Val Ile Cys Leu Tyr Gly Phe Gln Glu
     130                 135                 140                
 Lys Glu Ala Phe Thr Lys Thr Pro Cys Tyr His Tyr Phe His Cys His
 145                 150                 155                 160
 Cys Leu Ala Arg Tyr Ile Gln His Met Glu Gln Glu Leu Lys Ala Gln
                 165                 170                 175    
 Gly Gln Glu Gln Glu Gln Glu Arg Gln His Ala Thr Thr Lys Gln Lys
             180                 185                 190        
 Ala Val Gly Val Gln Cys Pro Val Cys Arg Glu Pro Leu Val Tyr Asp
         195                 200                 205            
 Leu Ala Ser Leu Lys Ala Ala Pro Glu Pro Gln Gln Pro Met Glu Leu
     210                 215                 220                
 Tyr Gln Pro Ser Ala Glu Ser Leu Arg Gln Gln Glu Glu Arg Lys Arg
 225                 230                 235                 240
 Leu Tyr Gln Arg Gln Gln Glu Arg Gly Gly Ile Ile Asp Leu Glu Ala
                 245                 250                 255    
 Glu Arg Asn Arg Tyr Phe Ile Ser Leu Gln Gln Pro Pro Ala Pro Ala
             260                 265                 270        
 Glu Pro Glu Ser Ala Val Asp Val Ser Lys Gly Ser Gln Pro Pro Ser
         275                 280                 285            
 Thr Leu Ala Ala Glu Leu Ser Thr Ser Pro Ala Val Gln Ser Thr Leu
     290                 295                 300                
 Pro Pro Pro Leu Pro Val Ala Thr Gln His Ile Cys Glu Lys Ile Pro
 305                 310                 315                 320
 Gly Thr Arg Ser Asn Gln Gln Arg Leu Gly Glu Thr Gln Lys Ala Met
                 325                 330                 335    
 Leu Asp Pro Pro Lys Pro Ser Arg Gly Pro Trp Arg Gln Pro Glu Arg
             340                 345                 350        
 Arg His Pro Lys Gly Gly Glu Cys His Ala Pro Lys Gly Thr Arg Asp
         355                 360                 365            
 Thr Gln Glu Leu Pro Pro Pro Glu Gly Pro Leu Lys Glu Pro Met Asp
     370                 375                 380                
 Leu Lys Pro Glu Pro His Ser Gln Gly Val Glu Gly Pro Pro Gln Glu
 385                 390                 395                 400
 Lys Gly Pro Gly Ser Trp Gln Gly Pro Pro Pro Arg Arg Thr Arg Asp
                 405                 410                 415    
 Cys Val Arg Trp Glu Arg Ser Lys Gly Arg Thr Pro Gly Ser Ser Tyr
             420                 425                 430        
 Pro Arg Leu Pro Arg Gly Gln Gly Ala Tyr Arg Pro Gly Thr Arg Arg
         435                 440                 445            
 Glu Ser Leu Gly Leu Glu Ser Lys Asp Gly Ser
     450                 455                



      <210> 1113
      <211> 549
      <212> PRT
      <213> Homo sapiens


      <400> 1113
 Met Asp Asp Lys Asp Ile Asp Lys Glu Leu Arg Gln Lys Leu Asn Phe
   1               5                  10                  15    
 Ser Tyr Cys Glu Glu Thr Glu Ile Glu Gly Gln Lys Lys Val Glu Glu
              20                  25                  30        
 Ser Arg Glu Ala Ser Ser Gln Thr Pro Glu Lys Gly Glu Val Gln Asp
          35                  40                  45            
 Ser Glu Ala Lys Gly Thr Pro Pro Trp Thr Pro Leu Ser Asn Val His
      50                  55                  60                
 Glu Leu Asp Thr Ser Ser Glu Lys Asp Lys Glu Ser Pro Asp Gln Ile
  65                  70                  75                  80
 Leu Arg Thr Pro Val Ser His Pro Leu Lys Cys Pro Glu Thr Pro Ala
                  85                  90                  95    
 Gln Pro Asp Ser Arg Ser Lys Leu Leu Pro Ser Asp Ser Pro Ser Thr
             100                 105                 110        
 Pro Lys Thr Met Leu Ser Arg Leu Val Ile Ser Pro Thr Gly Lys Leu
         115                 120                 125            
 Pro Ser Arg Gly Pro Lys His Leu Lys Leu Thr Pro Ala Pro Leu Lys
     130                 135                 140                
 Asp Glu Met Thr Ser Leu Ala Leu Val Asn Ile Asn Pro Phe Thr Pro
 145                 150                 155                 160
 Glu Ser Tyr Lys Lys Leu Phe Leu Gln Ser Gly Gly Lys Arg Lys Ile
                 165                 170                 175    
 Arg Arg Cys Val Leu Arg Glu Thr Asn Met Ala Ser Arg Tyr Glu Lys
             180                 185                 190        
 Glu Phe Leu Glu Val Glu Lys Ile Gly Val Gly Glu Phe Gly Thr Val
         195                 200                 205            
 Tyr Lys Cys Ile Lys Arg Leu Asp Gly Cys Val Tyr Ala Ile Lys Arg
     210                 215                 220                
 Ser Met Lys Thr Phe Thr Glu Leu Ser Asn Glu Asn Ser Ala Leu His
 225                 230                 235                 240
 Glu Val Tyr Ala His Ala Val Leu Gly His His Pro His Val Val Arg
                 245                 250                 255    
 Tyr Tyr Ser Ser Trp Ala Glu Asp Asp His Met Ile Ile Gln Asn Glu
             260                 265                 270        
 Tyr Cys Asn Gly Gly Ser Leu Gln Ala Ala Ile Ser Glu Asn Thr Lys
         275                 280                 285            
 Ser Gly Asn His Phe Glu Glu Pro Lys Leu Lys Asp Ile Leu Leu Gln
     290                 295                 300                
 Ile Ser Leu Gly Leu Asn Tyr Ile His Asn Ser Ser Met Val His Leu
 305                 310                 315                 320
 Asp Ile Lys Pro Ser Asn Ile Phe Ile Cys His Lys Met Gln Ser Glu
                 325                 330                 335    
 Ser Ser Gly Val Ile Glu Glu Val Glu Asn Glu Ala Asp Trp Phe Leu
             340                 345                 350        
 Ser Ala Asn Val Met Tyr Lys Ile Gly Asp Leu Gly His Ala Thr Ser
         355                 360                 365            
 Ile Asn Lys Pro Lys Val Glu Glu Gly Asp Ser Arg Phe Leu Ala Asn
     370                 375                 380                
 Glu Ile Leu Gln Glu Asp Tyr Arg His Leu Pro Lys Ala Asp Ile Phe
 385                 390                 395                 400
 Ala Leu Gly Leu Thr Ile Ala Val Ala Ala Gly Ala Glu Ser Leu Pro
                 405                 410                 415    
 Thr Asn Gly Ala Ala Trp His His Ile Arg Lys Gly Asn Phe Pro Asp
             420                 425                 430        
 Val Pro Gln Glu Leu Ser Glu Ser Phe Ser Ser Leu Leu Lys Asn Met
         435                 440                 445            
 Ile Gln Pro Asp Ala Glu Gln Arg Pro Ser Ala Ala Ala Leu Ala Arg
     450                 455                 460                
 Asn Thr Val Leu Arg Pro Ser Leu Gly Lys Thr Glu Glu Leu Gln Gln
 465                 470                 475                 480
 Gln Leu Asn Leu Glu Lys Phe Lys Thr Ala Thr Leu Glu Arg Glu Leu
                 485                 490                 495    
 Arg Glu Ala Gln Gln Ala Gln Ser Pro Gln Gly Tyr Thr His His Gly
             500                 505                 510        
 Asp Thr Gly Val Ser Gly Thr His Thr Gly Ser Arg Ser Thr Lys Arg
         515                 520                 525            
 Leu Val Gly Gly Lys Ser Ala Arg Ser Ser Ser Phe Thr Ser Gly Glu
     530                 535                 540                
 Arg Glu Pro Leu His
 545                



      <210> 1114
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 1114
 Met Val Gly Gln Thr Glu Asp Asp Thr Ala Gln Gln Leu Val Pro Thr
   1               5                  10                  15    
 Cys Gly Met Lys Gly Val Gly Glu Arg Ile Val Glu Tyr Val Ser Asn
              20                  25                  30        
 Ile Pro Ala Leu Gln Arg Ala Thr Pro Lys Gly Leu Ala Ser Val Ser
          35                  40                  45            
 Pro Asp Leu Glu His Arg Gln Glu Trp Thr Tyr Ser Lys Ser Pro Leu
      50                  55                  60                
 Met Gly Lys Gly Thr Arg Leu Glu Ala Ser Glu Asn Lys Arg Ala Gly
  65                  70                  75                  80
 Trp Leu Ala Ala Ala Pro Glu Asn Leu Lys Tyr His Arg Gln Ile Ala
                  85                  90                  95    
 Gln Gly Ala Lys Asp Tyr Glu Ile Leu Lys Lys Glu Thr Asn Lys Phe
             100                 105                 110        
 Ile Leu Arg Ile Tyr Thr His Trp Ser Arg Arg Ser Ile Leu Arg Lys
         115                 120                 125            
 Gly Ser Lys Gly Met Gln Asn Leu
     130                 135    



      <210> 1115
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 1115
 Met Gly Val Ser Lys Leu Asp Ile Leu Tyr Arg Arg Leu Leu Leu Thr
   1               5                  10                  15    
 Lys Leu Phe Ile Arg Gly Trp Gly Arg Pro Glu Asp Leu Lys Arg Leu
              20                  25                  30        
 Phe Glu Phe Arg Lys Met Ile Gly Asn Arg Glu Arg Cys Gln Asn Leu
          35                  40                  45            
 Val Ser Ser Asp Tyr Pro Val His Ile Asp Lys Ile Glu Glu Gln Ser
      50                  55                  60                
 Asp Cys Lys Ile Leu Asp Gly His Phe Val Ser Pro Met Ala His Tyr
  65                  70                  75                  80
 Val Pro Asp Ile Met Pro Ile Glu Ser Val Ile Ala Arg Phe Gln Phe
                  85                  90                  95    
 Ile Val Pro Lys Glu Trp Asn Ser Lys Tyr Arg Pro Val Cys Ile His
             100                 105                 110        
 Leu Ala Gly Thr Gly Asp His His Tyr Trp Arg Arg Arg Thr Leu Met
         115                 120                 125            
 Ala Arg Pro Met Ile Lys Glu Ala Arg Met Ala Ser Leu Leu Leu Glu
     130                 135                 140                
 Asn Pro Tyr
 145        



      <210> 1116
      <211> 44
      <212> PRT
      <213> Homo sapiens


      <400> 1116
 Met Pro Thr His Leu Ala Asn Phe Cys Ile Phe Ser Arg Val Glu Val
   1               5                  10                  15    
 Ser Pro Cys Trp Thr Gly Trp Ser Arg Ile Pro Gly Gln Val Ser Arg
              20                  25                  30        
 Leu Pro Trp Pro Pro Lys Val Leu Gly Phe His Ala
          35                  40                



      <210> 1117
      <211> 511
      <212> PRT
      <213> Homo sapiens


      <400> 1117
 Met Ile Pro Lys Leu Leu Ser Leu Leu Cys Phe Arg Ser Leu Pro Lys
   1               5                  10                  15    
 Pro Ser Leu Ser Ala Trp Pro Ser Ser Val Val Pro Ala Asn Ser Asn
              20                  25                  30        
 Val Thr Leu Arg Cys Trp Thr Pro Ala Arg Gly Val Ser Phe Val Leu
          35                  40                  45            
 Arg Lys Gly Gly Ile Ile Leu Glu Ser Pro Lys Pro Leu Asp Ser Thr
      50                  55                  60                
 Glu Gly Ala Ala Glu Phe His Leu Asn Asn Leu Lys Val Arg Asn Ala
  65                  70                  75                  80
 Gly Glu Tyr Thr Cys Glu Tyr Tyr Arg Lys Ala Ser Pro His Ile Leu
                  85                  90                  95    
 Ser Gln Arg Ser Asp Val Leu Leu Leu Leu Val Thr Gly His Leu Ser
             100                 105                 110        
 Lys Pro Phe Leu Arg Thr Tyr Gln Arg Gly Thr Val Thr Ala Gly Gly
         115                 120                 125            
 Arg Val Thr Leu Gln Cys Gln Lys Arg Asp Gln Leu Phe Val Pro Ile
     130                 135                 140                
 Met Phe Ala Leu Leu Lys Ala Gly Thr Pro Ser Pro Ile Gln Leu Gln
 145                 150                 155                 160
 Ser Pro Ala Gly Lys Glu Ile Asp Phe Ser Leu Val Asp Val Thr Ala
                 165                 170                 175    
 Gly Asp Ala Gly Asn Tyr Ser Cys Met Tyr Tyr Gln Thr Lys Ser Pro
             180                 185                 190        
 Phe Trp Ala Ser Glu Pro Ser Asp Gln Leu Glu Ile Leu Val Thr Val
         195                 200                 205            
 Pro Pro Gly Thr Thr Ser Ser Asn Tyr Ser Leu Gly Asn Phe Val Arg
     210                 215                 220                
 Leu Gly Leu Ala Ala Val Ile Val Val Ile Met Gly Ala Phe Leu Val
 225                 230                 235                 240
 Glu Ala Trp Tyr Ser Arg Asn Val Ser Pro Gly Leu Cys Leu Gly Tyr
                 245                 250                 255    
 Glu Asp Glu Lys Lys Asn Glu Lys Pro Pro Lys Pro Ser Leu His Ala
             260                 265                 270        
 Trp Pro Ser Ser Val Val Glu Ala Glu Ser Asn Val Thr Leu Lys Cys
         275                 280                 285            
 Gln Ala His Ser Gln Asn Val Thr Phe Val Leu Arg Lys Val Asn Asp
     290                 295                 300                
 Ser Gly Tyr Lys Gln Glu Gln Ser Ser Ala Glu Asn Glu Ala Glu Phe
 305                 310                 315                 320
 Pro Phe Thr Asp Leu Lys Pro Lys Asp Ala Gly Arg Tyr Phe Cys Ala
                 325                 330                 335    
 Tyr Lys Thr Thr Ala Ser His Glu Trp Ser Glu Ser Ser Glu His Leu
             340                 345                 350        
 Gln Leu Val Val Thr Gly Ser Leu Pro Glu Pro Leu Leu Ser Val Asn
         355                 360                 365            
 Val Asp Pro Gly Met Thr Pro Gly Leu Arg Thr Leu Arg Cys Leu Thr
     370                 375                 380                
 Pro Tyr Asn Gly Thr Glu Cys Ile Val Ile Ala Leu Leu Lys Met Gly
 385                 390                 395                 400
 Ile Pro Glu Pro Leu Gln Val Arg Gln Val Arg Lys Asn Gln Thr Asp
                 405                 410                 415    
 Phe Met Leu Trp Asn Val Thr Ser Asn Asp Ser Gly Asn Tyr Ser Cys
             420                 425                 430        
 Val Tyr Tyr Leu Ser Asn Ser Ser His Leu Ala Ser Phe Pro Ser Asn
         435                 440                 445            
 Lys Leu Glu Ile Trp Val Thr Asp Lys His Asp Glu Leu Glu Ala Pro
     450                 455                 460                
 Ser Met Lys Thr Asp Thr Arg Thr Ile Phe Val Ala Ile Phe Ser Cys
 465                 470                 475                 480
 Ile Ser Ile Leu Leu Leu Phe Leu Ser Val Phe Ile Ile Tyr Arg Cys
                 485                 490                 495    
 Ser Gln His Ser Glu Leu Arg Glu Arg Lys Gly Arg Glu Gly Glu
             500                 505                 510    



      <210> 1118
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 1118
 Met Thr Ala Glu Phe Leu Ser Leu Leu Cys Leu Gly Leu Cys Leu Gly
   1               5                  10                  15    
 Tyr Glu Asp Glu Lys Lys Asn Glu Lys Pro Pro Lys Pro Ser Leu His
              20                  25                  30        
 Ala Trp Pro Ser Ser Val Val Glu Ala Glu Ser Asn Val Thr Leu Lys
          35                  40                  45            
 Cys Gln Ala His Ser Gln Asn Val Thr Phe Val Leu Arg Lys Val Asn
      50                  55                  60                
 Asp Ser Gly Tyr Lys Gln Glu Gln Ser Ser Ala Glu Asn Glu Ala Glu
  65                  70                  75                  80
 Phe Pro Phe Thr Asp Leu Lys Pro Lys Asp Ala Gly Arg Tyr Phe Cys
                  85                  90                  95    
 Ala Tyr Lys Thr Thr Ala Ser His Glu Trp Ser Glu Ser Ser Glu His
             100                 105                 110        
 Leu Gln Leu Val Val Thr Gly Ser Leu Pro Glu Pro Leu Leu Ser Val
         115                 120                 125            
 Asn Val Asp Pro Gly Met Thr Pro Gly Leu Arg Thr Leu Arg Cys Leu
     130                 135                 140                
 Thr Pro Tyr Asn Gly Thr Glu Cys Ile Val Ile Ala Leu Leu Lys Met
 145                 150                 155                 160
 Gly Ile Pro Glu Pro Leu Gln Val Arg Gln Val Arg Lys Asn Gln Thr
                 165                 170                 175    
 Asp Phe Met Leu Trp Asn Val Thr Ser Asn Asp Ser Gly Asn Tyr Ser
             180                 185                 190        
 Cys Val Tyr Tyr Leu Ser Asn Ser Ser His Leu Ala Ser Phe Pro Ser
         195                 200                 205            
 Asn Lys Leu Glu Ile Trp Val Thr Asp Lys His Asp Glu Leu Glu Ala
     210                 215                 220                
 Pro Ser Met Lys Thr Asp Thr Arg Thr Ile Phe Val Ala Ile Phe Ser
 225                 230                 235                 240
 Cys Ile Ser Ile Leu Leu Leu Phe Leu Ser Val Phe Ile Ile Tyr Arg
                 245                 250                 255    
 Cys Ser Gln His Ser Glu Leu Arg Glu Arg Lys Gly Arg Glu Gly Glu
             260                 265                 270        





      <210> 1119
      <211> 975
      <212> PRT
      <213> Homo sapiens


      <400> 1119
 Met Asp Leu Asn Ser Ala Ser Thr Val Val Leu Gln Val Leu Thr Gln
   1               5                  10                  15    
 Ala Thr Ser Gln Asp Thr Ala Val Leu Lys Pro Ala Glu Glu Gln Leu
              20                  25                  30        
 Lys Gln Trp Glu Thr Gln Pro Gly Phe Tyr Ser Val Leu Leu Asn Ile
          35                  40                  45            
 Phe Thr Asn His Thr Leu Asp Ile Asn Val Arg Trp Leu Ala Val Leu
      50                  55                  60                
 Tyr Phe Lys His Gly Ile Asp Arg Tyr Trp Arg Arg Val Ala Pro His
  65                  70                  75                  80
 Ala Leu Ser Glu Glu Glu Lys Thr Thr Leu Arg Ala Gly Leu Ile Thr
                  85                  90                  95    
 Asn Phe Asn Glu Pro Ile Asn Gln Ile Ala Thr Gln Ile Ala Val Leu
             100                 105                 110        
 Ile Ala Lys Val Ala Arg Leu Asp Cys Pro Arg Gln Trp Pro Glu Leu
         115                 120                 125            
 Ile Pro Thr Leu Ile Glu Ser Val Lys Val Gln Asp Asp Leu Arg Gln
     130                 135                 140                
 His Arg Ala Leu Leu Thr Phe Tyr His Val Thr Lys Thr Leu Ala Ser
 145                 150                 155                 160
 Lys Arg Leu Ala Ala Asp Arg Lys Leu Phe Tyr Asp Leu Ala Ser Gly
                 165                 170                 175    
 Ile Tyr Asn Phe Ala Cys Ser Leu Trp Asn His His Thr Asp Thr Phe
             180                 185                 190        
 Leu Gln Glu Val Ser Ser Gly Asn Glu Ala Ala Ile Leu Ser Ser Leu
         195                 200                 205            
 Glu Arg Thr Leu Leu Ser Leu Lys Val Leu Arg Lys Leu Thr Val Asn
     210                 215                 220                
 Gly Phe Val Glu Pro His Lys Asn Met Glu Val Met Gly Phe Leu His
 225                 230                 235                 240
 Gly Ile Phe Glu Arg Leu Lys Gln Phe Leu Glu Cys Ser Arg Ser Ile
                 245                 250                 255    
 Gly Thr Asp Asn Val Cys Arg Asp Arg Leu Glu Lys Thr Ile Ile Leu
             260                 265                 270        
 Phe Thr Lys Val Leu Leu Asp Phe Leu Asp Gln His Pro Phe Ser Phe
         275                 280                 285            
 Thr Pro Leu Ile Gln Arg Ser Leu Glu Phe Ser Val Ser Tyr Val Phe
     290                 295                 300                
 Thr Glu Val Gly Glu Gly Val Thr Phe Glu Arg Phe Ile Val Gln Cys
 305                 310                 315                 320
 Met Asn Leu Ile Lys Met Ile Val Lys Asn Tyr Ala Tyr Lys Pro Ser
                 325                 330                 335    
 Lys Asn Phe Glu Asp Ser Ser Pro Glu Thr Leu Glu Ala His Lys Ile
             340                 345                 350        
 Lys Met Ala Phe Phe Thr Tyr Pro Thr Leu Thr Glu Ile Cys Arg Arg
         355                 360                 365            
 Leu Val Ser His Tyr Phe Leu Leu Thr Glu Glu Glu Leu Thr Met Trp
     370                 375                 380                
 Glu Glu Asp Pro Glu Gly Phe Thr Val Glu Glu Thr Gly Gly Asp Ser
 385                 390                 395                 400
 Trp Lys Tyr Ser Leu Arg Pro Cys Thr Glu Val Leu Phe Ile Asp Ile
                 405                 410                 415    
 Phe His Glu Tyr Asn Gln Thr Leu Thr Pro Val Leu Leu Glu Met Met
             420                 425                 430        
 Gln Thr Leu Gln Gly Pro Thr Asn Val Glu Asp Met Asn Ala Leu Leu
         435                 440                 445            
 Ile Lys Asp Ala Val Tyr Asn Ala Val Gly Leu Ala Ala Tyr Glu Leu
     450                 455                 460                
 Phe Asp Ser Val Asp Phe Asp Gln Trp Phe Lys Asn Gln Leu Leu Pro
 465                 470                 475                 480
 Glu Leu Gln Val Ile His Asn Arg Tyr Lys Pro Leu Arg Arg Arg Val
                 485                 490                 495    
 Ile Trp Leu Ile Gly Gln Trp Val Ser Val Lys Phe Lys Ser Asp Leu
             500                 505                 510        
 Arg Pro Met Leu Tyr Glu Ala Ile Cys Asn Leu Leu Gln Asp Gln Asp
         515                 520                 525            
 Leu Val Val Arg Ile Glu Thr Ala Thr Thr Leu Lys Leu Thr Val Asp
     530                 535                 540                
 Asp Phe Glu Phe Arg Thr Asp Gln Phe Leu Pro Tyr Leu Glu Thr Met
 545                 550                 555                 560
 Phe Thr Leu Leu Phe Gln Leu Leu Gln Gln Ala Thr Glu Cys Asp Thr
                 565                 570                 575    
 Lys Met His Val Leu His Val Leu Ser Cys Val Ile Glu Arg Val Asn
             580                 585                 590        
 Met Gln Ile Arg Pro Tyr Val Gly Cys Leu Val Gln Tyr Leu Pro Leu
         595                 600                 605            
 Leu Trp Lys Gln Ser Glu Glu His Asn Met Leu Arg Cys Ala Ile Leu
     610                 615                 620                
 Thr Thr Leu Ile His Leu Val Gln Gly Leu Gly Ala Asp Ser Lys Asn
 625                 630                 635                 640
 Leu Tyr Pro Phe Leu Leu Pro Val Ile Gln Leu Ser Thr Asp Val Ser
                 645                 650                 655    
 Gln Pro Pro His Val Tyr Leu Leu Glu Asp Gly Leu Glu Leu Trp Leu
             660                 665                 670        
 Val Thr Leu Glu Asn Ser Pro Cys Ile Thr Pro Glu Leu Leu Arg Ile
         675                 680                 685            
 Phe Gln Asn Met Ser Pro Leu Leu Glu Leu Ser Ser Glu Asn Leu Arg
     690                 695                 700                
 Thr Cys Phe Lys Ile Ile Asn Gly Tyr Ile Phe Leu Ser Ser Thr Glu
 705                 710                 715                 720
 Phe Leu Gln Thr Tyr Ala Val Gly Leu Cys Gln Ser Phe Cys Glu Leu
                 725                 730                 735    
 Leu Lys Glu Ile Thr Thr Glu Gly Gln Val Gln Val Leu Lys Val Val
             740                 745                 750        
 Glu Asn Ala Leu Lys Val Asn Pro Ile Leu Gly Pro Gln Met Phe Gln
         755                 760                 765            
 Pro Ile Leu Pro Tyr Val Phe Lys Gly Ile Ile Glu Gly Glu Arg Tyr
     770                 775                 780                
 Pro Val Val Met Ser Thr Tyr Leu Gly Val Met Gly Arg Val Leu Leu
 785                 790                 795                 800
 Gln Asn Thr Ser Phe Phe Ser Ser Leu Leu Asn Glu Met Ala His Lys
                 805                 810                 815    
 Phe Asn Gln Glu Met Asp Gln Leu Leu Gly Asn Met Ile Glu Met Trp
             820                 825                 830        
 Val Asp Arg Met Asp Asn Ile Thr Gln Pro Glu Arg Arg Lys Leu Ser
         835                 840                 845            
 Ala Leu Ala Leu Leu Ser Leu Leu Pro Ser Asp Asn Ser Val Ile Gln
     850                 855                 860                
 Asp Lys Phe Cys Gly Ile Ile Asn Ile Ser Val Glu Gly Leu His Asp
 865                 870                 875                 880
 Val Met Thr Glu Asp Pro Glu Thr Gly Thr Tyr Lys Asp Cys Met Leu
                 885                 890                 895    
 Met Ser His Leu Glu Glu Pro Lys Val Thr Glu Asp Glu Glu Pro Pro
             900                 905                 910        
 Thr Glu Gln Asp Lys Arg Lys Lys Met Leu Ala Leu Lys Asp Pro Val
         915                 920                 925            
 His Thr Val Ser Leu Gln Gln Phe Ile Tyr Glu Lys Leu Lys Ala Gln
     930                 935                 940                
 Gln Glu Met Leu Gly Glu Gln Gly Phe Gln Ser Leu Met Glu Thr Val
 945                 950                 955                 960
 Asp Thr Glu Ile Val Thr Gln Leu Gln Glu Phe Leu Gln Gly Phe
                 965                 970                 975



      <210> 1120
      <211> 1090
      <212> PRT
      <213> Homo sapiens


      <400> 1120
 Met Met Pro Met Ile Leu Thr Val Phe Leu Ser Asn Asn Glu Gln Ile
   1               5                  10                  15    
 Leu Thr Glu Val Pro Ile Thr Pro Glu Thr Thr Cys Arg Asp Val Val
              20                  25                  30        
 Glu Phe Cys Lys Glu Pro Gly Glu Gly Ser Cys His Leu Ala Glu Val
          35                  40                  45            
 Trp Arg Gly Asn Glu Arg Pro Ile Pro Phe Asp His Met Met Tyr Glu
      50                  55                  60                
 His Leu Gln Ile Trp Gly Pro Arg Arg Glu Glu Val Lys Phe Phe Leu
  65                  70                  75                  80
 Arg His Glu Asp Ser Pro Thr Glu Asn Ser Glu Gln Gly Gly Arg Gln
                  85                  90                  95    
 Thr Gln Glu Gln Arg Thr Gln Arg Asn Val Ile Asn Val Pro Gly Asp
             100                 105                 110        
 Lys Arg Thr Glu Tyr Gly Val Gly Tyr Pro Arg Val Glu Leu Thr Leu
         115                 120                 125            
 Ser Glu Leu Gln Asp Met Ala Ala Arg Gln Gln Gln Gln Ile Glu Asn
     130                 135                 140                
 Gln Gln Gln Met Leu Val Ala Lys Glu Gln Arg Leu His Phe Leu Lys
 145                 150                 155                 160
 Gln Gln Glu Arg Arg Gln Gln Gln Ser Ile Ser Glu Asn Glu Lys Leu
                 165                 170                 175    
 Gln Lys Leu Lys Glu Arg Val Glu Ala Gln Glu Asn Lys Leu Lys Lys
             180                 185                 190        
 Ile Arg Ala Met Arg Gly Gln Val Asp Tyr Ser Lys Ile Met Asn Gly
         195                 200                 205            
 Asn Leu Ser Ala Glu Ile Glu Arg Phe Ser Ala Met Phe Gln Glu Lys
     210                 215                 220                
 Lys Gln Glu Val Gln Thr Ala Ile Leu Arg Val Asp Gln Leu Ser Gln
 225                 230                 235                 240
 Gln Leu Glu Asp Leu Lys Lys Gly Lys Leu Asn Gly Phe Gln Ser Tyr
                 245                 250                 255    
 Asn Gly Lys Leu Thr Gly Pro Ala Ala Val Glu Leu Lys Arg Leu Tyr
             260                 265                 270        
 Gln Glu Leu Gln Ile Arg Asn Gln Leu Asn Gln Glu Gln Asn Ser Lys
         275                 280                 285            
 Leu Gln Gln Gln Lys Glu Leu Leu Asn Lys Arg Asn Met Glu Val Ala
     290                 295                 300                
 Met Met Asp Lys Arg Ile Ser Glu Leu Arg Glu Arg Leu Tyr Gly Lys
 305                 310                 315                 320
 Lys Ile Gln Leu Asn Arg Val Asn Gly Thr Ser Ser Pro Gln Ser Pro
                 325                 330                 335    
 Leu Ser Thr Ser Gly Arg Val Ala Ala Val Gly Pro Tyr Ile Gln Val
             340                 345                 350        
 Pro Ser Ala Gly Ser Phe Pro Val Leu Gly Asp Pro Ile Lys Pro Gln
         355                 360                 365            
 Ser Leu Ser Ile Ala Ser Asn Ala Ala His Gly Arg Ser Lys Ser Ala
     370                 375                 380                
 Asn Asp Gly Asn Trp Pro Thr Leu Lys Gln Asn Ser Ser Ser Ser Val
 385                 390                 395                 400
 Lys Pro Val Gln Val Ala Gly Ala Asp Trp Lys Asp Pro Ser Val Glu
                 405                 410                 415    
 Gly Ser Val Lys Gln Gly Thr Val Ser Ser Gln Pro Val Pro Phe Ser
             420                 425                 430        
 Ala Leu Gly Pro Thr Glu Lys Pro Gly Ile Glu Ile Gly Lys Val Pro
         435                 440                 445            
 Pro Pro Ile Pro Gly Val Gly Lys Gln Leu Pro Pro Ser Tyr Gly Thr
     450                 455                 460                
 Tyr Pro Ser Pro Thr Pro Leu Gly Pro Gly Ser Thr Ser Ser Leu Glu
 465                 470                 475                 480
 Arg Arg Lys Glu Gly Ser Leu Pro Arg Pro Ser Ala Gly Leu Pro Ser
                 485                 490                 495    
 Arg Gln Arg Pro Thr Leu Leu Pro Ala Thr Gly Ser Thr Pro Gln Pro
             500                 505                 510        
 Gly Ser Ser Gln Gln Ile Gln Gln Arg Ile Ser Val Pro Pro Ser Pro
         515                 520                 525            
 Thr Tyr Pro Pro Ala Gly Pro Pro Ala Phe Pro Ala Gly Asp Ser Lys
     530                 535                 540                
 Pro Glu Leu Pro Leu Thr Val Ala Ile Arg Pro Phe Leu Ala Asp Lys
 545                 550                 555                 560
 Gly Ser Arg Pro Gln Ser Pro Arg Lys Gly Pro Gln Thr Val Asn Ser
                 565                 570                 575    
 Ser Ser Ile Tyr Ser Met Tyr Leu Gln Gln Ala Thr Pro Pro Lys Asn
             580                 585                 590        
 Tyr Gln Pro Ala Ala His Ser Ala Leu Asn Lys Ser Val Lys Ala Val
         595                 600                 605            
 Tyr Gly Lys Pro Val Leu Pro Ser Gly Ser Thr Ser Pro Ser Pro Leu
     610                 615                 620                
 Pro Phe Leu His Gly Ser Leu Ser Thr Gly Thr Pro Gln Pro Gln Pro
 625                 630                 635                 640
 Pro Ser Glu Ser Thr Glu Lys Glu Pro Glu Gln Asp Gly Pro Ala Ala
                 645                 650                 655    
 Pro Ala Asp Gly Ser Thr Val Glu Ser Leu Pro Arg Pro Leu Ser Pro
             660                 665                 670        
 Thr Lys Leu Thr Pro Ile Val His Ser Pro Leu Arg Tyr Gln Ser Asp
         675                 680                 685            
 Ala Asp Leu Glu Ala Leu Arg Arg Lys Leu Ala Asn Ala Pro Arg Pro
     690                 695                 700                
 Leu Lys Lys Arg Ser Ser Ile Thr Glu Pro Glu Gly Pro Gly Gly Pro
 705                 710                 715                 720
 Asn Ile Gln Lys Leu Leu Tyr Gln Arg Phe Asn Thr Leu Ala Gly Gly
                 725                 730                 735    
 Met Glu Gly Thr Pro Phe Tyr Gln Pro Ser Pro Ser Gln Asp Phe Met
             740                 745                 750        
 Gly Thr Leu Ala Asp Val Asp Asn Gly Asn Thr Asn Ala Asn Gly Asn
         755                 760                 765            
 Leu Glu Glu Leu Pro Pro Ala Gln Pro Thr Ala Pro Leu Pro Ala Glu
     770                 775                 780                
 Pro Ala Pro Ser Ser Asp Ala Asn Asp Asn Glu Leu Pro Ser Pro Glu
 785                 790                 795                 800
 Pro Glu Glu Leu Ile Cys Pro Gln Thr Thr His Gln Thr Ala Glu Pro
                 805                 810                 815    
 Ala Glu Asp Asn Asn Asn Asn Val Ala Thr Val Pro Thr Thr Glu Gln
             820                 825                 830        
 Ile Pro Ser Pro Val Ala Glu Ala Pro Ser Pro Gly Glu Glu Gln Val
         835                 840                 845            
 Pro Pro Ala Pro Leu Pro Pro Ala Ser His Pro Pro Ala Thr Ser Thr
     850                 855                 860                
 Asn Lys Arg Thr Asn Leu Lys Lys Pro Asn Ser Glu Arg Thr Gly His
 865                 870                 875                 880
 Gly Leu Arg Val Arg Phe Asn Pro Leu Ala Leu Leu Leu Asp Ala Ser
                 885                 890                 895    
 Leu Glu Gly Glu Phe Asp Leu Val Gln Arg Ile Ile Tyr Glu Val Glu
             900                 905                 910        
 Asp Pro Ser Lys Pro Asn Asp Glu Gly Ile Thr Pro Leu His Asn Ala
         915                 920                 925            
 Val Cys Ala Gly His His His Ile Val Lys Phe Leu Leu Asp Phe Gly
     930                 935                 940                
 Val Asn Val Asn Ala Ala Asp Ser Asp Gly Trp Thr Pro Leu His Cys
 945                 950                 955                 960
 Ala Ala Ser Cys Asn Ser Val His Leu Cys Lys Gln Leu Val Glu Ser
                 965                 970                 975    
 Gly Ala Ala Ile Phe Ala Ser Thr Ile Ser Asp Ile Glu Thr Ala Ala
             980                 985                 990        
 Asp Lys Cys Glu Glu Met Glu Glu Gly Tyr Ile Gln Cys Ser Gln Phe
         995                1000                1005            
 Leu Tyr Gly Val Gln Glu Lys Leu Gly Val Met Asn Lys Gly Val Ala
    1010                1015                1020                
 Tyr Ala Leu Trp Asp Tyr Glu Ala Gln Asn Ser Asp Glu Leu Ser Phe
1025                1030                1035                1040
 His Glu Gly Asp Ala Leu Thr Ile Leu Arg Arg Lys Asp Glu Ser Glu
                1045                1050                1055    
 Thr Glu Trp Trp Trp Ala Arg Leu Gly Asp Arg Glu Gly Tyr Val Pro
            1060                1065                1070        
 Lys Asn Leu Leu Gly Leu Tyr Pro Arg Ile Lys Pro Arg Gln Arg Thr
        1075                1080                1085            
 Leu Ala
    1090



      <210> 1121
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 1121
 Met Tyr Gly Met Leu Glu Trp Pro Ile Ser Met Tyr Phe Val Ala Phe
   1               5                  10                  15    
 Leu His Cys Phe Leu Cys Ser Gly Gly Asn Leu Gly Asp Ser Phe Gln
              20                  25                  30        
 Ala Leu Pro Glu Leu Cys Ala Asn Cys Ser Ser Ser Pro Arg Val Leu
          35                  40                  45            
 Cys Cys Val Val Met Ser Pro Leu Pro
      50                  55        



      <210> 1122
      <211> 379
      <212> PRT
      <213> Homo sapiens


      <400> 1122
 Met Asp Pro Arg Lys Val Asn Glu Leu Arg Ala Phe Val Lys Met Cys
   1               5                  10                  15    
 Lys Gln Asp Pro Ser Val Leu His Thr Glu Glu Met Arg Phe Leu Arg
              20                  25                  30        
 Glu Trp Val Glu Ser Met Gly Gly Lys Val Pro Pro Ala Thr Gln Lys
          35                  40                  45            
 Ala Lys Ser Glu Glu Asn Thr Lys Glu Glu Lys Pro Asp Ser Lys Lys
      50                  55                  60                
 Val Glu Glu Asp Leu Lys Ala Asp Glu Pro Ser Ser Glu Glu Ser Asp
  65                  70                  75                  80
 Leu Gly Leu Ile Val Ile Phe Ser Thr Leu Ala Glu Ile Asp Lys Glu
                  85                  90                  95    
 Gly Val Ile Glu Pro Asp Thr Asp Ala Pro Gln Glu Met Gly Asp Glu
             100                 105                 110        
 Asn Ala Glu Ile Thr Glu Glu Met Met Asp Gln Ala Asn Asp Lys Lys
         115                 120                 125            
 Val Ala Ala Ile Glu Ala Leu Asn Asp Gly Glu Leu Gln Lys Ala Ile
     130                 135                 140                
 Asp Leu Phe Thr Asp Ala Ile Lys Leu Asn Pro Arg Leu Ala Ile Leu
 145                 150                 155                 160
 Tyr Ala Lys Arg Ala Ser Val Phe Val Lys Leu Gln Lys Pro Asn Ala
                 165                 170                 175    
 Ala Ile Arg Asp Cys Asp Arg Ala Ile Glu Ile Asn Pro Asp Ser Ala
             180                 185                 190        
 Gln Pro Tyr Lys Trp Arg Gly Lys Ala His Arg Leu Leu Gly His Trp
         195                 200                 205            
 Glu Glu Ala Ala His Asp Leu Ala Leu Ala Cys Lys Leu Asp Tyr Asp
     210                 215                 220                
 Glu Asp Ala Ser Ala Met Leu Lys Glu Val Gln Pro Arg Ala Gln Lys
 225                 230                 235                 240
 Ile Ala Glu His Arg Arg Lys Tyr Glu Arg Lys Arg Glu Glu Arg Glu
                 245                 250                 255    
 Ile Lys Glu Arg Ile Glu Arg Val Lys Lys Ala Arg Glu Glu His Glu
             260                 265                 270        
 Arg Ala Gln Arg Glu Glu Glu Ala Arg Arg Gln Ser Gly Ala Gln Tyr
         275                 280                 285            
 Gly Ser Phe Pro Gly Gly Phe Pro Gly Gly Met Pro Gly Asn Phe Pro
     290                 295                 300                
 Gly Gly Met Pro Gly Met Gly Gly Gly Met Pro Gly Met Ala Gly Met
 305                 310                 315                 320
 Pro Gly Leu Asn Glu Ile Leu Ser Asp Pro Glu Val Leu Ala Ala Met
                 325                 330                 335    
 Gln Asp Pro Glu Val Met Val Ala Phe Gln Asp Val Ala Gln Asn Pro
             340                 345                 350        
 Ala Asn Met Ser Lys Tyr Gln Ser Asn Pro Lys Val Met Asn Leu Ile
         355                 360                 365            
 Ser Lys Leu Ser Ala Lys Phe Gly Gly Gln Ala
     370                 375                



      <210> 1123
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 1123
 Met Ala Arg Ile Leu Leu Leu Phe Leu Pro Gly Leu Val Ala Val Cys
   1               5                  10                  15    
 Ala Val His Gly Ile Phe Met Asp Arg Leu Ala Ser Lys Lys Leu Cys
              20                  25                  30        
 Ala Asp Asp Glu Cys Val Tyr Thr Ile Ser Leu Ala Ser Ala Gln Glu
          35                  40                  45            
 Asp Tyr Asn Ala Pro Asp Cys Arg Phe Ile Asn Val Lys Lys Gly Gln
      50                  55                  60                
 Gln Ile Tyr Val Tyr Ser Lys Leu Val Lys Glu Asn Gly Ala Gly Glu
  65                  70                  75                  80
 Phe Trp Ala Gly Ser Val Tyr Gly Asp Gly Gln Asp Glu Met Gly Val
                  85                  90                  95    
 Val Gly Tyr Phe Pro Arg Asn Leu Val Lys Glu Gln Arg Val Tyr Gln
             100                 105                 110        
 Glu Ala Thr Lys Glu Val Pro Thr Thr Asp Ile Asp Phe Phe Cys Glu
         115                 120                 125            





      <210> 1124
      <211> 244
      <212> PRT
      <213> Homo sapiens


      <400> 1124
 Met Asp Asp Lys Glu Pro Lys Arg Trp Pro Thr Leu Arg Asp Arg Leu
   1               5                  10                  15    
 Cys Ser Asp Gly Phe Leu Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His
              20                  25                  30        
 Leu Lys Gly Ile His Arg Ala Val Phe Tyr Arg Asp Leu Glu Glu Leu
          35                  40                  45            
 Lys Phe Val Leu Leu Thr Arg Tyr Asp Ile Asn Lys Arg Asp Arg Lys
      50                  55                  60                
 Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met
  65                  70                  75                  80
 Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg
                  85                  90                  95    
 Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala
             100                 105                 110        
 Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asp Pro Asn Ile Thr Asp
         115                 120                 125            
 Val Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr
     130                 135                 140                
 Ser Met Ile Glu Lys Leu Leu Ser Tyr Gly Ala Asn Ile Glu Glu Cys
 145                 150                 155                 160
 Ser Glu Asp Glu Tyr Pro Pro Leu Phe Leu Ala Val Ser Gln Arg Lys
                 165                 170                 175    
 Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Ile Asn Ala
             180                 185                 190        
 Val Asp Tyr Leu Gly Arg Ser Ala Leu Ile His Ala Val Thr Leu Gly
         195                 200                 205            
 Glu Lys Asp Ile Val Ile Leu Leu Leu Gln His Asn Ile Asp Val Phe
     210                 215                 220                
 Ser Arg Asp Val Tyr Gly Lys Leu Ala Glu Asp Tyr Ala Ser Glu Ala
 225                 230                 235                 240
 Lys Asn Arg Val
                



      <210> 1125
      <211> 307
      <212> PRT
      <213> Homo sapiens


      <400> 1125
 Met Asp Asp Lys Glu Pro Lys Arg Trp Pro Thr Leu Arg Asp Arg Leu
   1               5                  10                  15    
 Cys Ser Asp Gly Phe Leu Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His
              20                  25                  30        
 Leu Lys Gly Ile His Arg Ala Val Phe Tyr Arg Asp Leu Glu Glu Leu
          35                  40                  45            
 Lys Phe Val Leu Leu Thr Arg Tyr Asp Ile Asn Lys Arg Asp Arg Lys
      50                  55                  60                
 Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met
  65                  70                  75                  80
 Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg
                  85                  90                  95    
 Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala
             100                 105                 110        
 Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asp Pro Asn Ile Thr Asp
         115                 120                 125            
 Val Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr
     130                 135                 140                
 Ser Met Ile Glu Lys Leu Leu Ser Tyr Gly Ala Asn Ile Glu Glu Cys
 145                 150                 155                 160
 Ser Glu Asp Glu Tyr Pro Pro Leu Phe Leu Ala Val Ser Gln Arg Lys
                 165                 170                 175    
 Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Ile Asn Ala
             180                 185                 190        
 Val Asp Tyr Leu Gly Ser Ile Phe Glu Leu Ile Tyr Glu Tyr Glu Arg
         195                 200                 205            
 Lys Lys His Glu Glu Leu Ser Ile Asn Ser Asn Pro Val Ser Ser Gln
     210                 215                 220                
 Lys Gln Pro Ala Leu Lys Ala Thr Ser Gly Lys Glu Asp Ser Ile Ser
 225                 230                 235                 240
 Asn Ile Ala Thr Glu Ile Lys Asp Gly Gln Lys Ser Gly Thr Val Ser
                 245                 250                 255    
 Ser Gln Lys Gln Pro Ala Leu Lys Gly Thr Ser Asp Lys Asn Asp Ser
             260                 265                 270        
 Val Ser Asn Thr Ala Thr Glu Ile Lys Asp Glu Gln Lys Ser Gly Thr
         275                 280                 285            
 Val Ser Ser Gln Lys Gln Pro Ala Leu Lys Val Leu Tyr Ser His Ser
     290                 295                 300                
 Tyr Phe Glu
 305        



      <210> 1126
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 1126
 Met Glu Ser Ser Ser Val Asp Gln Ser Gly Val Gln Trp Arg Asp Leu
   1               5                  10                  15    
 Gly Ser Pro Gly Phe Lys Arg Phe Ser Cys Leu Ser Leu Pro Ser Ser
              20                  25                  30        
 Trp Asp Tyr Arg Arg Gly Pro Pro Cys Leu Asp Asn Phe Cys Ile Phe
          35                  40                  45            
 His His Val Gly Gln Ala Gly Leu Glu Leu Leu Thr Ser Gly Asp Leu
      50                  55                  60                
 Pro Ala Ser Ala Ser Gln Ser Ala Gly Thr Lys Arg Val Ser His His
  65                  70                  75                  80
 Thr Arg Pro Lys Ser
                  85



      <210> 1127
      <211> 96
      <212> PRT
      <213> Homo sapiens


      <400> 1127
 Met Ser Val Val Pro Ile Leu Glu Gly Gln Ala Leu Arg Ile Cys Ser
   1               5                  10                  15    
 Trp His Gly Ala Ala Ala Pro Arg Pro Pro Gly Trp Pro Ser Arg Gly
              20                  25                  30        
 Ser Arg Gln Gln Val His Gly Glu His Gly Pro Ala Ala Arg Val Leu
          35                  40                  45            
 Cys Gly Cys Gly Gly Arg Gln Arg Gln Leu Pro Arg Arg Lys Ser Val
      50                  55                  60                
 Trp Ser Arg Leu Leu Gln Ala Leu Glu Arg Gly Arg Glu Arg Gln Leu
  65                  70                  75                  80
 Arg Pro Leu Trp Glu Arg Asn Pro Pro Ser Leu Gln Arg Leu Arg Val
                  85                  90                  95    





      <210> 1128
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 1128
 Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp
   1               5                  10                  15    
 Leu Leu Thr Thr Trp Gly Cys Ile Val Phe Ser Gly Ser Tyr Ala Trp
              20                  25                  30        
 Ala Asn Phe Thr Ile Leu Ala Leu Gly Val Trp Ala Val Ala Gln Arg
          35                  40                  45            
 Asp Ser Ile Asp Ala Ile Ser Met Phe Leu Gly Gly Leu Leu Ala Thr
      50                  55                  60                
 Ile Phe Leu Asp Ile Val His Ile Ser Ile Phe Tyr Pro Arg Val Ser
  65                  70                  75                  80
 Leu Thr Asp Thr Gly Arg Phe Gly Val Gly Met Ala Ile Leu Ser Leu
                  85                  90                  95    
 Leu Leu Lys Pro Leu Ser Cys Cys Phe Val Tyr His Met Tyr Arg Glu
             100                 105                 110        
 Arg Gly Gly Phe Leu Gly Ser Ser Gln Asp Arg Ser Ala Tyr Gln Thr
         115                 120                 125            
 Ile Asp Ser Ala Glu Ala Pro Ala Asp Pro Phe
     130                 135                



      <210> 1129
      <211> 380
      <212> PRT
      <213> Homo sapiens


      <400> 1129
 Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro
   1               5                  10                  15    
 Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp
              20                  25                  30        
 Ala Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser
          35                  40                  45            
 Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg
      50                  55                  60                
 Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp
  65                  70                  75                  80
 Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr
                  85                  90                  95    
 Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met
             100                 105                 110        
 Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser
         115                 120                 125            
 Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr
     130                 135                 140                
 Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu
 145                 150                 155                 160
 Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly
                 165                 170                 175    
 Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu
             180                 185                 190        
 Leu Tyr Thr Leu Asp Lys Lys Pro Leu Lys Pro Leu Arg Asp Val Ile
         195                 200                 205            
 Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg
     210                 215                 220                
 Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys
 225                 230                 235                 240
 Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile
                 245                 250                 255    
 Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp
             260                 265                 270        
 His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val
         275                 280                 285            
 Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Asn Leu
     290                 295                 300                
 Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Pro Thr Pro Gly Arg
 305                 310                 315                 320
 Ser Arg Ala Phe Thr Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu
                 325                 330                 335    
 Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro
             340                 345                 350        
 Gln Ile Leu Met Met Glu Leu Ala His Gly Leu Gln Asp Gln Asn Leu
         355                 360                 365            
 Lys Ile Ser Leu Thr Val Cys His Gln Thr Thr Gln
     370                 375                 380



      <210> 1130
      <211> 1288
      <212> PRT
      <213> Homo sapiens


      <400> 1130
 Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro
   1               5                  10                  15    
 Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp
              20                  25                  30        
 Ala Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser
          35                  40                  45            
 Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg
      50                  55                  60                
 Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp
  65                  70                  75                  80
 Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr
                  85                  90                  95    
 Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met
             100                 105                 110        
 Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser
         115                 120                 125            
 Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr
     130                 135                 140                
 Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu
 145                 150                 155                 160
 Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly
                 165                 170                 175    
 Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu
             180                 185                 190        
 Leu Tyr Arg Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile
         195                 200                 205            
 Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg
     210                 215                 220                
 Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys
 225                 230                 235                 240
 Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile
                 245                 250                 255    
 Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp
             260                 265                 270        
 His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val
         275                 280                 285            
 Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Tyr Leu
     290                 295                 300                
 Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Pro Thr Pro Gly Arg
 305                 310                 315                 320
 Ser Arg Ala Phe Arg Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu
                 325                 330                 335    
 Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro
             340                 345                 350        
 Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln
         355                 360                 365            
 Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro
     370                 375                 380                
 Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr
 385                 390                 395                 400
 Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Arg Arg Gly Ser
                 405                 410                 415    
 Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu
             420                 425                 430        
 Phe Gln Pro Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu
         435                 440                 445            
 Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His
     450                 455                 460                
 Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala
 465                 470                 475                 480
 Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Gly Cys Leu Asp
                 485                 490                 495    
 Asn Ser Ser Gly Ser Gly Cys Lys Ser Pro Leu Gly Gly Phe Gln Gly
             500                 505                 510        
 Cys Leu Arg Leu Ile Thr Ile Gly Asp Lys Ala Val Asp Pro Ile Leu
         515                 520                 525            
 Val Gln Gln Gly Ala Leu Gly Ser Phe Arg Asp Leu Gln Ile Asp Ser
     530                 535                 540                
 Cys Gly Ile Thr Asp Arg Cys Leu Pro Ser Tyr Cys Glu His Gly Gly
 545                 550                 555                 560
 Glu Cys Ser Gln Ser Trp Asp Thr Phe Ser Cys Asp Cys Leu Gly Thr
                 565                 570                 575    
 Gly Tyr Thr Gly Glu Thr Cys His Ser Ser Leu Tyr Glu Gln Ser Cys
             580                 585                 590        
 Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr Tyr Ile Asp
         595                 600                 605            
 Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr Cys Asn Met
     610                 615                 620                
 Thr Ala Asp Ala Ala Trp Thr Val Val Gln His Gly Gly Pro Asp Ala
 625                 630                 635                 640
 Val Thr Leu Arg Gly Ala Pro Ser Gly His Pro Arg Ser Ala Val Ser
                 645                 650                 655    
 Phe Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ser Ala Val Asn Leu
             660                 665                 670        
 Ala Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly Thr Ala Arg
         675                 680                 685            
 Arg Pro Asp Ser Arg Asp Gly Thr Pro Leu Ser Trp Trp Val Gly Arg
     690                 695                 700                
 Thr Asn Glu Thr His Thr Tyr Trp Gly Val Ser Leu Pro Asp Ala Gln
 705                 710                 715                 720
 Lys Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln Tyr Tyr
                 725                 730                 735    
 Cys Asn Cys Asp Ala Gly Arg Asn Glu Trp Thr Ser Asp Thr Ile Val
             740                 745                 750        
 Leu Ser Gln Lys Glu His Leu Pro Val Thr Gln Ile Val Met Thr Asp
         755                 760                 765            
 Ala Gly Arg Pro His Ser Glu Ala Ala Tyr Thr Leu Gly Pro Leu Leu
     770                 775                 780                
 Cys Arg Gly Asp Gln Ser Phe Trp Asn Ser Ala Ser Phe Asn Thr Glu
 785                 790                 795                 800
 Thr Ser Tyr Leu His Phe Pro Ala Phe His Gly Glu Leu Thr Ala Asp
                 805                 810                 815    
 Val Cys Phe Phe Phe Lys Thr Thr Val Ser Ser Gly Val Phe Met Glu
             820                 825                 830        
 Asn Leu Gly Ile Thr Asp Phe Ile Arg Ile Glu Leu His Ala Pro Thr
         835                 840                 845            
 Glu Val Thr Phe Ser Phe Asp Val Gly Asn Gly Pro Cys Glu Val Thr
     850                 855                 860                
 Val Gln Ser Pro Thr Pro Phe Asn Asp Asn Gln Trp His His Val Arg
 865                 870                 875                 880
 Ala Glu Arg Asn Val Lys Gly Ala Ser Leu Gln Val Asp Gln Leu Pro
                 885                 890                 895    
 Gln Lys Met Gln Pro Ala Pro Ala Asp Gly His Val Arg Leu Gln Leu
             900                 905                 910        
 Asn Ser Gln Leu Phe Ile Gly Gly Thr Ala Thr Arg Gln Arg Gly Phe
         915                 920                 925            
 Leu Gly Cys Ile Arg Ser Leu Gln Leu Asn Gly Val Ala Leu Asp Leu
     930                 935                 940                
 Glu Glu Arg Ala Thr Val Thr Pro Gly Val Glu Pro Gly Cys Ala Gly
 945                 950                 955                 960
 His Cys Ser Thr Tyr Gly His Leu Cys Arg Asn Gly Gly Arg Cys Arg
                 965                 970                 975    
 Glu Lys Arg Arg Gly Val Thr Cys Asp Cys Ala Phe Ser Ala Tyr Asp
             980                 985                 990        
 Gly Pro Phe Cys Ser Asn Glu Ile Ser Ala Tyr Phe Ala Thr Gly Ser
         995                1000                1005            
 Ser Met Thr Tyr His Phe Gln Glu His Tyr Thr Leu Ser Glu Asn Ser
    1010                1015                1020                
 Ser Ser Leu Val Ser Ser Leu His Arg Asp Val Thr Leu Thr Arg Glu
1025                1030                1035                1040
 Met Ile Thr Leu Ser Phe Arg Thr Thr Arg Thr Pro Ser Leu Leu Leu
                1045                1050                1055    
 Tyr Val Ser Ser Phe Tyr Glu Glu Tyr Leu Ser Val Ile Leu Ala Asn
            1060                1065                1070        
 Asn Gly Ser Leu Gln Ile Arg Tyr Lys Leu Asp Arg His Gln Asn Pro
        1075                1080                1085            
 Asp Ala Phe Thr Phe Asp Phe Lys Asn Met Ala Asp Gly Gln Leu His
    1090                1095                1100                
 Gln Val Lys Ile Asn Arg Glu Glu Ala Val Val Met Val Glu Val Asn
1105                1110                1115                1120
 Gln Ser Thr Lys Lys Gln Val Ile Leu Ser Ser Gly Thr Glu Phe Asn
                1125                1130                1135    
 Ala Val Lys Ser Leu Ile Leu Gly Lys Val Leu Glu Ala Ala Gly Ala
            1140                1145                1150        
 Asp Pro Asp Thr Arg Arg Ala Ala Thr Ser Gly Phe Thr Gly Cys Leu
        1155                1160                1165            
 Ser Ala Val Arg Phe Gly Arg Ala Ala Pro Leu Lys Ala Ala Leu Arg
    1170                1175                1180                
 Pro Ser Gly Pro Ser Arg Val Thr Val Arg Gly His Val Ala Pro Met
1185                1190                1195                1200
 Ala Arg Cys Ala Ala Gly Ala Ala Ser Gly Ser Pro Ala Arg Glu Leu
                1205                1210                1215    
 Ala Pro Arg Leu Ala Gly Gly Ala Gly Arg Ser Gly Pro Ala Asp Glu
            1220                1225                1230        
 Gly Glu Pro Leu Val Asn Ala Asp Arg Arg Asp Ser Ala Val Ile Gly
        1235                1240                1245            
 Gly Val Ile Ala Val Val Ile Phe Ile Leu Leu Cys Ile Thr Ala Ile
    1250                1255                1260                
 Ala Ile Arg Ile Tyr Gln Gln Arg Lys Leu Arg Lys Glu Asn Glu Ser
1265                1270                1275                1280
 Lys Val Ser Lys Lys Glu Glu Cys
                1285            



      <210> 1131
      <211> 598
      <212> PRT
      <213> Homo sapiens


      <400> 1131
 Met Val Ser Leu Arg Lys Val Lys Val Leu Leu Val Leu Asn Met Ile
   1               5                  10                  15    
 Arg Val Ala Gly Phe Val Leu Phe Leu Gly Lys Cys Arg Pro Ile Ala
              20                  25                  30        
 Val Arg Ser Gly Asp Ala Phe His Glu Ile Arg Pro Arg Ala Glu Val
          35                  40                  45            
 Ala Asn Leu Ser Ala His Ser Ala Ser Pro Ile Gln Asp Ala Val Leu
      50                  55                  60                
 Lys Arg Leu Ser Leu Leu Glu Asp Ile Val Tyr Arg Gln Leu Asn Gly
  65                  70                  75                  80
 Leu Ser Lys Ser Leu Gly Leu Ile Glu Gly Tyr Gly Gly Arg Gly Lys
                  85                  90                  95    
 Gly Gly Leu Pro Ala Thr Leu Ser Pro Ala Glu Glu Glu Lys Ala Lys
             100                 105                 110        
 Gly Pro His Glu Lys Tyr Gly Tyr Asn Ser Tyr Leu Ser Glu Lys Ile
         115                 120                 125            
 Ser Leu Asp Arg Ser Ile Pro Asp Tyr Arg Pro Thr Lys Cys Lys Glu
     130                 135                 140                
 Leu Lys Tyr Ser Lys Asp Leu Pro Gln Ile Ser Ile Ile Phe Ile Phe
 145                 150                 155                 160
 Val Asn Glu Ala Leu Ser Val Ile Leu Arg Ser Val His Ser Ala Val
                 165                 170                 175    
 Asn His Thr Pro Thr His Leu Leu Lys Glu Ile Ile Leu Val Asp Asp
             180                 185                 190        
 Asn Ser Asp Glu Glu Glu Leu Lys Val Pro Leu Glu Glu Tyr Val His
         195                 200                 205            
 Lys Arg Tyr Pro Gly Leu Val Lys Val Val Arg Asn Gln Lys Arg Glu
     210                 215                 220                
 Gly Leu Ile Arg Ala Arg Ile Glu Gly Trp Lys Val Ala Thr Gly Gln
 225                 230                 235                 240
 Val Thr Gly Phe Phe Asp Ala His Val Glu Phe Thr Ala Gly Trp Ala
                 245                 250                 255    
 Glu Pro Val Leu Ser Arg Ile Gln Glu Asn Arg Lys Arg Val Ile Leu
             260                 265                 270        
 Pro Ser Ile Asp Asn Ile Lys Gln Asp Asn Phe Glu Val Gln Arg Tyr
         275                 280                 285            
 Glu Asn Ser Ala His Gly Tyr Ser Trp Glu Leu Trp Cys Met Tyr Ile
     290                 295                 300                
 Ser Pro Pro Lys Asp Trp Trp Asp Ala Gly Asp Pro Ser Leu Pro Ile
 305                 310                 315                 320
 Arg Thr Pro Ala Met Ile Gly Cys Ser Phe Val Val Asn Arg Lys Phe
                 325                 330                 335    
 Phe Gly Glu Ile Gly Leu Leu Asp Pro Gly Met Asp Val Tyr Gly Gly
             340                 345                 350        
 Glu Asn Ile Glu Leu Gly Ile Lys Val Trp Leu Cys Gly Gly Ser Met
         355                 360                 365            
 Glu Val Leu Pro Cys Ser Arg Val Ala His Ile Glu Arg Lys Lys Lys
     370                 375                 380                
 Pro Tyr Asn Ser Asn Ile Gly Phe Tyr Thr Lys Arg Asn Ala Leu Arg
 385                 390                 395                 400
 Val Ala Glu Val Trp Met Asp Asp Tyr Lys Ser His Val Tyr Ile Ala
                 405                 410                 415    
 Trp Asn Leu Pro Leu Glu Asn Pro Gly Ile Asp Ile Gly Asp Val Ser
             420                 425                 430        
 Glu Arg Arg Ala Leu Arg Lys Ser Leu Lys Cys Lys Asn Phe Gln Trp
         435                 440                 445            
 Tyr Leu Asp His Val Tyr Pro Glu Met Arg Arg Tyr Asn Asn Thr Val
     450                 455                 460                
 Ala Tyr Gly Glu Leu Arg Asn Asn Lys Ala Lys Asp Val Cys Leu Asp
 465                 470                 475                 480
 Gln Gly Pro Leu Glu Asn His Thr Ala Ile Leu Tyr Pro Cys His Gly
                 485                 490                 495    
 Trp Gly Pro Gln Leu Ala Arg Tyr Thr Lys Glu Gly Phe Leu His Leu
             500                 505                 510        
 Gly Ala Leu Gly Thr Thr Thr Leu Leu Pro Asp Thr Arg Cys Leu Val
         515                 520                 525            
 Asp Asn Ser Lys Ser Arg Leu Pro Gln Leu Leu Asp Cys Asp Lys Val
     530                 535                 540                
 Lys Ser Ser Leu Tyr Lys Arg Trp Asn Phe Ile Gln Asn Gly Ala Ile
 545                 550                 555                 560
 Met Asn Lys Gly Thr Gly Arg Cys Leu Glu Val Glu Asn Arg Gly Leu
                 565                 570                 575    
 Ala Gly Ile Asp Leu Ile Leu Arg Ser Cys Thr Gly Gln Arg Trp Thr
             580                 585                 590        
 Ile Lys Asn Ser Ile Lys
         595            



      <210> 1132
      <211> 243
      <212> PRT
      <213> Homo sapiens


      <400> 1132
 Met Gln Phe Arg Leu Phe Ser Phe Ala Leu Ile Ile Leu Asn Cys Met
   1               5                  10                  15    
 Asp Tyr Ser His Cys Gln Gly Asn Arg Trp Arg Arg Ser Lys Arg Ala
              20                  25                  30        
 Ser Tyr Val Ser Asn Pro Ile Cys Lys Gly Cys Leu Ser Cys Ser Lys
          35                  40                  45            
 Asp Asn Gly Cys Ser Arg Cys Gln Gln Lys Leu Phe Phe Phe Leu Arg
      50                  55                  60                
 Arg Glu Gly Met Arg Gln Tyr Gly Glu Cys Leu His Ser Cys Pro Ser
  65                  70                  75                  80
 Gly Tyr Tyr Gly His Arg Ala Pro Asp Met Asn Arg Cys Ala Arg Cys
                  85                  90                  95    
 Arg Ile Glu Asn Cys Asp Ser Cys Phe Ser Lys Asp Phe Cys Thr Lys
             100                 105                 110        
 Cys Lys Val Gly Phe Tyr Leu His Arg Gly Arg Cys Phe Asp Glu Cys
         115                 120                 125            
 Pro Asp Gly Phe Ala Pro Leu Glu Glu Thr Met Glu Cys Val Glu Gly
     130                 135                 140                
 Cys Glu Val Gly His Trp Ser Glu Trp Gly Thr Cys Ser Arg Asn Asn
 145                 150                 155                 160
 Arg Thr Cys Gly Phe Lys Trp Gly Leu Glu Thr Arg Thr Arg Gln Ile
                 165                 170                 175    
 Val Lys Lys Pro Val Lys Asp Thr Ile Pro Cys Pro Thr Ile Ala Glu
             180                 185                 190        
 Ser Arg Arg Cys Lys Met Thr Met Arg His Cys Pro Gly Gly Lys Arg
         195                 200                 205            
 Thr Pro Lys Ala Lys Glu Lys Arg Asn Lys Lys Lys Lys Arg Lys Leu
     210                 215                 220                
 Ile Glu Arg Ala Gln Glu Gln His Ser Val Phe Leu Ala Thr Asp Arg
 225                 230                 235                 240
 Ala Asn Gln
            



      <210> 1133
      <211> 616
      <212> PRT
      <213> Homo sapiens


      <400> 1133
 Met Ser Thr Ile Gln Ser Glu Thr Asp Cys Tyr Asp Ile Ile Glu Val
   1               5                  10                  15    
 Leu Gly Lys Gly Thr Phe Gly Glu Val Ala Lys Gly Trp Arg Arg Ser
              20                  25                  30        
 Thr Gly Glu Met Val Ala Ile Lys Ile Leu Lys Asn Asp Ala Tyr Arg
          35                  40                  45            
 Asn Arg Ile Ile Lys Asn Glu Leu Lys Leu Leu His Cys Met Arg Gly
      50                  55                  60                
 Leu Asp Pro Glu Glu Ala His Val Ile Arg Phe Leu Glu Phe Phe His
  65                  70                  75                  80
 Asp Ala Leu Lys Phe Tyr Leu Val Phe Glu Leu Leu Glu Gln Asn Leu
                  85                  90                  95    
 Phe Glu Phe Gln Lys Glu Asn Asn Phe Ala Pro Leu Pro Ala Arg His
             100                 105                 110        
 Ile Arg Thr Val Thr Leu Gln Val Leu Thr Ala Leu Ala Arg Leu Lys
         115                 120                 125            
 Glu Leu Ala Ile Ile His Ala Asp Leu Lys Pro Glu Asn Ile Met Leu
     130                 135                 140                
 Val Asp Gln Thr Arg Cys Pro Phe Arg Val Lys Val Ile Asp Phe Gly
 145                 150                 155                 160
 Ser Ala Ser Ile Phe Ser Glu Val Arg Tyr Val Lys Glu Pro Tyr Ile
                 165                 170                 175    
 Gln Ser Arg Phe Tyr Arg Ala Pro Glu Ile Leu Leu Gly Leu Pro Phe
             180                 185                 190        
 Cys Glu Lys Val Asp Val Trp Ser Leu Gly Cys Val Met Ala Glu Leu
         195                 200                 205            
 His Leu Gly Trp Pro Leu Tyr Pro Gly Asn Asn Glu Tyr Asp Gln Val
     210                 215                 220                
 Arg Tyr Ile Cys Glu Thr Gln Gly Leu Pro Lys Pro His Leu Leu His
 225                 230                 235                 240
 Ala Ala Cys Lys Ala His His Phe Phe Lys Arg Asn Pro His Pro Asp
                 245                 250                 255    
 Ala Ala Asn Pro Trp Gln Leu Lys Ser Ser Ala Asp Tyr Leu Ala Glu
             260                 265                 270        
 Thr Lys Val Arg Pro Leu Glu Arg Arg Lys Tyr Met Leu Lys Ser Leu
         275                 280                 285            
 Asp Gln Ile Glu Thr Val Asn Gly Gly Ser Val Ala Ser Arg Leu Thr
     290                 295                 300                
 Phe Pro Asp Arg Glu Ala Leu Ala Glu His Ala Asp Leu Lys Ser Met
 305                 310                 315                 320
 Val Glu Leu Ile Lys Arg Met Leu Thr Trp Glu Ser His Glu Arg Ile
                 325                 330                 335    
 Ser Pro Ser Ala Ala Leu Arg His Pro Phe Val Ser Met Gln Gln Leu
             340                 345                 350        
 Arg Ser Ala His Glu Thr Thr His Tyr Tyr Gln Leu Ser Leu Arg Ser
         355                 360                 365            
 Tyr Arg Leu Ser Leu Gln Val Glu Gly Lys Pro Pro Thr Pro Val Val
     370                 375                 380                
 Ala Ala Glu Asp Gly Thr Pro Tyr Tyr Cys Leu Ala Glu Glu Lys Glu
 385                 390                 395                 400
 Ala Ala Gly Met Gly Ser Val Ala Gly Ser Ser Pro Phe Phe Arg Glu
                 405                 410                 415    
 Glu Lys Ala Pro Gly Met Gln Arg Ala Ile Asp Gln Leu Asp Asp Leu
             420                 425                 430        
 Ser Leu Gln Glu Ala Gly His Gly Leu Trp Gly Glu Thr Cys Thr Asn
         435                 440                 445            
 Ala Val Ser Asp Met Met Val Pro Leu Lys Ala Ala Ile Thr Gly His
     450                 455                 460                
 His Val Pro Asp Ser Gly Pro Glu Pro Ile Leu Ala Phe Tyr Ser Ser
 465                 470                 475                 480
 Arg Leu Ala Gly Arg His Lys Ala Arg Lys Pro Pro Ala Gly Ser Lys
                 485                 490                 495    
 Ser Asp Ser Asn Phe Ser Asn Leu Ile Arg Leu Ser Gln Val Ser Pro
             500                 505                 510        
 Glu Asp Asp Arg Pro Cys Arg Gly Ser Ser Trp Glu Glu Gly Glu His
         515                 520                 525            
 Leu Gly Ala Ser Ala Glu Pro Leu Ala Ile Leu Gln Arg Asp Glu Asp
     530                 535                 540                
 Gly Pro Asn Ile Asp Asn Met Thr Met Glu Ala Glu Arg Pro Asp Pro
 545                 550                 555                 560
 Glu Leu Phe Asp Pro Ser Ser Cys Pro Gly Glu Trp Leu Ser Glu Pro
                 565                 570                 575    
 Asp Cys Thr Leu Glu Ser Val Arg Gly Pro Arg Ala Gln Gly Leu Pro
             580                 585                 590        
 Pro Arg Arg Ser His Gln His Gly Pro Pro Arg Gly Ala Thr Ser Phe
         595                 600                 605            
 Leu Gln His Val Thr Gly His His
     610                 615    



      <210> 1134
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 1134
 Met Leu Asp Asp Leu Phe Gln Ser Met Phe Leu Cys Ala Leu Leu Leu
   1               5                  10                  15    
 Phe Trp Leu Cys Val Tyr His Gly Ile Arg Val Gln Gly Glu Arg Lys
              20                  25                  30        
 Cys Leu Thr Phe Tyr Leu Pro Lys Phe Phe Ile Val Gly Leu Leu Trp
          35                  40                  45            
 Leu Ala Ser Val Thr Leu Gly Ile Trp Gln Thr Glu
      50                  55                  60



      <210> 1135
      <211> 803
      <212> PRT
      <213> Homo sapiens


      <400> 1135
 Met Ala Lys Arg Ser Ser Leu Tyr Ile Arg Ile Val Glu Gly Lys Asn
   1               5                  10                  15    
 Leu Pro Ala Lys Asp Ile Thr Gly Ser Ser Asp Pro Tyr Cys Ile Val
              20                  25                  30        
 Lys Val Asp Asn Glu Pro Ile Ile Arg Thr Ala Thr Val Trp Lys Thr
          35                  40                  45            
 Leu Cys Pro Phe Trp Gly Glu Glu Tyr Gln Val His Leu Pro Pro Thr
      50                  55                  60                
 Phe His Ala Val Ala Phe Tyr Val Met Asp Glu Asp Ala Leu Ser Arg
  65                  70                  75                  80
 Asp Asp Val Ile Gly Lys Val Cys Leu Thr Arg Asp Thr Ile Ala Ser
                  85                  90                  95    
 His Pro Lys Gly Phe Ser Gly Trp Ala His Leu Thr Glu Val Asp Pro
             100                 105                 110        
 Asp Glu Glu Val Gln Gly Glu Ile His Leu Arg Leu Glu Val Trp Pro
         115                 120                 125            
 Gly Ala Arg Ala Cys Arg Leu Arg Cys Ser Val Leu Glu Ala Arg Asp
     130                 135                 140                
 Leu Ala Pro Lys Asp Arg Asn Gly Thr Ser Asp Pro Phe Val Arg Val
 145                 150                 155                 160
 Arg Tyr Lys Gly Arg Thr Arg Glu Thr Ser Ile Val Lys Lys Ser Cys
                 165                 170                 175    
 Tyr Pro Arg Trp Asn Glu Thr Phe Glu Phe Glu Leu Gln Glu Gly Ala
             180                 185                 190        
 Met Glu Ala Leu Cys Val Glu Ala Trp Asp Trp Asp Leu Val Ser Arg
         195                 200                 205            
 Asn Asp Phe Leu Gly Lys Val Val Ile Asp Val Gln Arg Leu Arg Val
     210                 215                 220                
 Val Gln Gln Glu Glu Gly Trp Phe Arg Leu Gln Pro Asp Gln Ser Lys
 225                 230                 235                 240
 Ser Arg Arg His Asp Glu Gly Asn Leu Gly Ser Leu Gln Leu Glu Val
                 245                 250                 255    
 Arg Leu Arg Asp Glu Thr Val Leu Pro Ser Ser Tyr Tyr Gln Pro Leu
             260                 265                 270        
 Val His Leu Leu Cys His Glu Val Lys Leu Gly Met Gln Gly Pro Gly
         275                 280                 285            
 Gln Leu Ile Pro Leu Ile Glu Glu Thr Thr Ser Thr Glu Cys Arg Gln
     290                 295                 300                
 Asp Val Ala Thr Asn Leu Leu Lys Leu Phe Leu Gly Gln Gly Leu Ala
 305                 310                 315                 320
 Lys Asp Phe Leu Asp Leu Leu Phe Gln Leu Glu Leu Ser Arg Thr Ser
                 325                 330                 335    
 Glu Thr Asn Thr Leu Phe Arg Ser Asn Ser Leu Ala Ser Lys Ser Met
             340                 345                 350        
 Glu Ser Phe Leu Lys Val Ala Gly Met Gln Tyr Leu His Gly Val Leu
         355                 360                 365            
 Gly Pro Ile Ile Asn Lys Val Phe Glu Glu Lys Lys Tyr Val Glu Leu
     370                 375                 380                
 Asp Pro Ser Lys Val Glu Val Lys Asp Val Gly Cys Ser Gly Leu His
 385                 390                 395                 400
 Arg Pro Gln Thr Glu Ala Glu Val Leu Glu Gln Ser Ala Gln Thr Leu
                 405                 410                 415    
 Arg Ala His Leu Gly Ala Leu Leu Ser Ala Leu Ser Arg Ser Val Arg
             420                 425                 430        
 Ala Cys Pro Ala Val Val Arg Ala Thr Phe Arg Gln Leu Phe Arg Arg
         435                 440                 445            
 Val Arg Glu Arg Phe Pro Gly Ala Gln His Glu Asn Val Pro Phe Ile
     450                 455                 460                
 Ala Val Thr Ser Phe Leu Cys Leu Arg Phe Phe Ser Pro Ala Ile Met
 465                 470                 475                 480
 Ser Pro Lys Leu Phe His Leu Arg Glu Arg His Ala Asp Ala Arg Thr
                 485                 490                 495    
 Ser Arg Thr Leu Leu Leu Leu Ala Lys Ala Val Gln Asn Val Gly Asn
             500                 505                 510        
 Met Asp Thr Pro Ala Ser Arg Ala Lys Glu Ala Trp Met Glu Pro Leu
         515                 520                 525            
 Gln Pro Thr Val Arg Gln Gly Val Ala Gln Leu Lys Asp Phe Ile Thr
     530                 535                 540                
 Lys Leu Val Asp Ile Glu Glu Lys Asp Glu Leu Asp Leu Gln Arg Thr
 545                 550                 555                 560
 Leu Ser Leu Gln Ala Pro Pro Val Lys Glu Gly Pro Leu Phe Ile His
                 565                 570                 575    
 Arg Thr Lys Gly Lys Gly Pro Leu Met Ser Ser Ser Phe Lys Lys Leu
             580                 585                 590        
 Tyr Phe Ser Leu Thr Thr Glu Ala Leu Ser Phe Ala Lys Met Pro Ser
         595                 600                 605            
 Ser Lys Lys Ser Ala Leu Ile Lys Leu Ala Asn Ile Arg Ala Ala Glu
     610                 615                 620                
 Lys Val Glu Glu Lys Ser Phe Gly Gly Ser His Val Met Gln Val Ile
 625                 630                 635                 640
 Tyr Thr Asp Asp Ala Gly Arg Pro Gln Thr Ala Tyr Leu Gln Cys Lys
                 645                 650                 655    
 Cys Val Asn Glu Leu Asn Gln Trp Leu Ser Ala Leu Arg Lys Val Ser
             660                 665                 670        
 Ile Asn Asn Thr Gly Leu Leu Gly Ser Tyr His Pro Gly Val Phe Arg
         675                 680                 685            
 Gly Asp Lys Trp Ser Cys Cys His Gln Lys Glu Lys Thr Gly Gln Gly
     690                 695                 700                
 Cys Asp Lys Thr Arg Ser Arg Val Thr Leu Gln Glu Trp Asn Asp Pro
 705                 710                 715                 720
 Leu Asp His Asp Leu Glu Ala Gln Leu Ile Tyr Arg His Leu Leu Gly
                 725                 730                 735    
 Val Glu Ala Met Leu Trp Glu Arg His Arg Glu Leu Ser Gly Gly Thr
             740                 745                 750        
 Glu Ala Gly Thr Val Pro Thr Ser Pro Gly Lys Val Pro Glu Asp Ser
         755                 760                 765            
 Leu Ala Arg Leu Leu Arg Val Leu Gln Asp Leu Arg Glu Ala His Ser
     770                 775                 780                
 Ser Ser Pro Ala Gly Ser Pro Pro Ser Glu Pro Asn Cys Leu Leu Glu
 785                 790                 795                 800
 Leu Gln Thr
            



      <210> 1136
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 1136
 Met Pro Trp Thr Ile Leu Leu Phe Ala Ala Gly Ser Leu Ala Ile Pro
   1               5                  10                  15    
 Ala Pro Ser Ile Arg Leu Val Pro Pro Tyr Pro Ser Ser Gln Glu Asp
              20                  25                  30        
 Pro Ile His Ile Ala Cys Met Ala Pro Gly Asn Phe Pro Gly Ala Asn
          35                  40                  45            
 Phe Thr Leu Tyr Arg Gly Gly Gln Val Val Gln Leu Leu Gln Ala Pro
      50                  55                  60                
 Thr Asp Gln Arg Gly Val Thr Phe Asn Leu Ser Gly Gly Ser Ser Lys
  65                  70                  75                  80
 Ala Pro Gly Gly Pro Phe His Cys Gln Tyr Gly Val Leu Gly Glu Leu
                  85                  90                  95    
 Asn Gln Ser Gln Leu Ser Asp Leu Ser Glu Pro Val Asn Val Ser Phe
             100                 105                 110        
 Pro Val Pro Thr Trp Ile Leu Val Leu Ser Leu Ser Leu Ala Gly Ala
         115                 120                 125            
 Leu Phe Leu Leu Ala Gly Leu Val Ala Val Ala Leu Val Val Arg Lys
     130                 135                 140                
 Val Lys Leu Arg Asn Leu Gln Lys Lys Arg Asp Arg Glu Ser Cys Trp
 145                 150                 155                 160
 Ala Gln Ile Asn Phe Asp Ser Thr Asp Met Ser Phe Asp Asn Ser Leu
                 165                 170                 175    
 Phe Thr Val Ser Ala Lys Thr Met Pro Glu Glu Asp Pro Ala Thr Leu
             180                 185                 190        
 Asp Asp His Ser Gly Thr Thr Ala Thr Pro Ser Asn Ser Arg Thr Arg
         195                 200                 205            
 Lys Arg Pro Thr Ser Thr Ser Ser Ser Pro Glu Thr Pro Glu Phe Ser
     210                 215                 220                
 Thr Phe Arg Ala Cys Gln
 225                 230



      <210> 1137
      <211> 595
      <212> PRT
      <213> Homo sapiens


      <400> 1137
 Met Asp Phe Leu Leu Ala Leu Val Leu Val Ser Ser Leu Tyr Leu Gln
   1               5                  10                  15    
 Ala Ala Ala Glu Phe Asp Gly Arg Trp Pro Arg Gln Ile Val Ser Ser
              20                  25                  30        
 Ile Gly Leu Cys Arg Tyr Gly Gly Arg Ile Asp Cys Cys Trp Gly Trp
          35                  40                  45            
 Ala Arg Gln Ser Trp Gly Gln Cys Gln Pro Val Cys Gln Pro Arg Cys
      50                  55                  60                
 Lys His Gly Glu Cys Ile Gly Pro Asn Lys Cys Lys Cys His Pro Gly
  65                  70                  75                  80
 Tyr Ala Gly Lys Thr Cys Asn Gln Asp Glu His Ile Pro Ala Pro Leu
                  85                  90                  95    
 Asp Gln Gly Ser Glu Gln Pro Leu Phe Gln Pro Leu Asp His Gln Ala
             100                 105                 110        
 Thr Ser Leu Pro Ser Arg Asp Leu Asn Glu Cys Gly Leu Lys Pro Arg
         115                 120                 125            
 Pro Cys Lys His Arg Cys Met Asn Thr Tyr Gly Ser Tyr Lys Cys Tyr
     130                 135                 140                
 Cys Leu Asn Gly Tyr Met Leu Met Pro Asp Gly Ser Cys Ser Ser Ala
 145                 150                 155                 160
 Leu Thr Cys Ser Met Ala Asn Cys Gln Tyr Gly Cys Asp Val Val Lys
                 165                 170                 175    
 Gly Gln Ile Arg Cys Gln Cys Pro Ser Pro Gly Leu Gln Leu Ala Pro
             180                 185                 190        
 Asp Gly Arg Thr Cys Val Asp Val Asp Glu Cys Ala Thr Gly Arg Ala
         195                 200                 205            
 Ser Cys Pro Arg Phe Arg Gln Cys Val Asn Thr Phe Gly Ser Tyr Ile
     210                 215                 220                
 Cys Lys Cys His Lys Gly Phe Asp Leu Met Tyr Ile Gly Gly Lys Tyr
 225                 230                 235                 240
 Gln Cys His Asp Ile Asp Glu Cys Ser Leu Gly Gln Tyr Gln Cys Ser
                 245                 250                 255    
 Ser Phe Ala Arg Cys Tyr Asn Val Arg Gly Ser Tyr Lys Cys Lys Cys
             260                 265                 270        
 Lys Glu Gly Tyr Gln Gly Asp Gly Leu Thr Cys Val Tyr Ile Pro Lys
         275                 280                 285            
 Val Met Ile Glu Pro Ser Gly Pro Ile His Val Pro Lys Gly Asn Gly
     290                 295                 300                
 Thr Ile Leu Lys Gly Asp Thr Gly Asn Asn Asn Trp Ile Pro Asp Val
 305                 310                 315                 320
 Gly Ser Thr Trp Trp Pro Pro Lys Thr Pro Tyr Ile Pro Pro Ile Ile
                 325                 330                 335    
 Thr Asn Arg Pro Thr Ser Lys Pro Thr Thr Arg Pro Thr Pro Lys Pro
             340                 345                 350        
 Thr Pro Ile Pro Thr Pro Pro Pro Pro Pro Pro Leu Pro Thr Glu Leu
         355                 360                 365            
 Arg Thr Pro Leu Pro Pro Thr Thr Pro Glu Arg Pro Thr Thr Gly Leu
     370                 375                 380                
 Thr Thr Ile Ala Pro Ala Ala Ser Thr Pro Pro Gly Gly Ile Thr Val
 385                 390                 395                 400
 Asp Asn Arg Val Gln Thr Asp Pro Gln Lys Pro Arg Gly Asp Val Phe
                 405                 410                 415    
 Ile Pro Arg Gln Pro Ser Asn Asp Leu Phe Glu Ile Phe Glu Ile Glu
             420                 425                 430        
 Arg Gly Val Ser Ala Asp Asp Glu Ala Lys Asp Asp Pro Gly Val Leu
         435                 440                 445            
 Val His Ser Cys Asn Phe Asp His Gly Leu Cys Gly Trp Ile Arg Glu
     450                 455                 460                
 Lys Asp Asn Asp Leu His Trp Glu Pro Ile Arg Asp Pro Ala Gly Gly
 465                 470                 475                 480
 Gln Tyr Leu Thr Val Ser Ala Ala Lys Ala Pro Gly Gly Lys Ala Ala
                 485                 490                 495    
 Arg Leu Val Leu Pro Leu Gly Arg Leu Met His Ser Gly Asp Leu Cys
             500                 505                 510        
 Leu Ser Phe Arg His Lys Val Thr Gly Leu His Ser Gly Thr Leu Gln
         515                 520                 525            
 Val Phe Val Arg Lys His Gly Ala His Gly Ala Ala Leu Trp Gly Arg
     530                 535                 540                
 Asn Gly Gly His Gly Trp Arg Gln Thr Gln Ile Thr Leu Arg Gly Ala
 545                 550                 555                 560
 Asp Ile Lys Ser Val Val Phe Lys Gly Glu Lys Arg Arg Gly His Thr
                 565                 570                 575    
 Gly Glu Ile Gly Leu Asp Asp Val Ser Leu Lys Lys Gly His Cys Ser
             580                 585                 590        
 Glu Glu Arg
         595



      <210> 1138
      <211> 496
      <212> PRT
      <213> Homo sapiens


      <400> 1138
 Met Val Lys Ser Tyr Ser Leu Leu Phe Arg Val Thr Arg Pro Gly Arg
   1               5                  10                  15    
 Arg Glu Phe Asn Gly Met Ile Asn Gly Glu Thr Asn Glu Asn Ile Asp
              20                  25                  30        
 Val Asn Glu Glu Leu Pro Ala Arg Arg Lys Arg Asn Arg Glu Asp Gly
          35                  40                  45            
 Glu Lys Thr Phe Val Ala Gln Met Thr Val Phe Asp Lys Asn Arg Arg
      50                  55                  60                
 Leu Gln Leu Leu Asp Gly Glu Tyr Glu Val Ala Met Gln Glu Met Glu
  65                  70                  75                  80
 Glu Cys Pro Ile Ser Lys Lys Arg Ala Thr Trp Glu Thr Ile Leu Asp
                  85                  90                  95    
 Gly Lys Arg Leu Pro Pro Phe Glu Thr Phe Ser Gln Gly Pro Thr Leu
             100                 105                 110        
 Gln Phe Thr Leu Arg Trp Thr Gly Glu Thr Asn Asp Lys Ser Thr Ala
         115                 120                 125            
 Pro Ile Ala Lys Pro Leu Ala Thr Arg Asn Ser Glu Ser Leu His Gln
     130                 135                 140                
 Glu Asn Lys Pro Gly Ser Val Lys Pro Thr Gln Thr Ile Ala Val Lys
 145                 150                 155                 160
 Glu Ser Leu Thr Thr Asp Leu Gln Thr Arg Lys Glu Lys Asp Thr Pro
                 165                 170                 175    
 Asn Glu Asn Arg Gln Lys Leu Arg Ile Phe Tyr Gln Phe Leu Tyr Asn
             180                 185                 190        
 Asn Asn Thr Arg Gln Gln Thr Glu Ala Arg Asp Asp Leu His Cys Pro
         195                 200                 205            
 Trp Cys Thr Leu Asn Cys Arg Lys Leu Tyr Ser Leu Leu Lys His Leu
     210                 215                 220                
 Lys Leu Cys His Ser Arg Phe Ile Phe Asn Tyr Val Tyr His Pro Lys
 225                 230                 235                 240
 Gly Ala Arg Ile Asp Val Ser Ile Asn Glu Cys Tyr Asp Gly Ser Tyr
                 245                 250                 255    
 Ala Gly Asn Pro Gln Asp Ile His Arg Gln Pro Gly Phe Ala Phe Ser
             260                 265                 270        
 Arg Asn Gly Pro Val Lys Arg Thr Pro Ile Thr His Ile Leu Val Cys
         275                 280                 285            
 Arg Pro Lys Arg Thr Lys Ala Ser Met Ser Glu Phe Leu Glu Ser Glu
     290                 295                 300                
 Asp Gly Glu Val Glu Gln Gln Arg Thr Tyr Ser Ser Gly His Asn Arg
 305                 310                 315                 320
 Leu Tyr Phe His Ser Asp Thr Cys Leu Pro Leu Arg Pro Gln Glu Met
                 325                 330                 335    
 Glu Val Asp Ser Glu Asp Glu Lys Asp Pro Glu Trp Leu Arg Glu Lys
             340                 345                 350        
 Thr Ile Thr Gln Ile Glu Glu Phe Ser Asp Val Asn Glu Gly Glu Lys
         355                 360                 365            
 Glu Val Met Lys Leu Trp Asn Leu His Val Met Lys His Gly Phe Ile
     370                 375                 380                
 Ala Asp Asn Gln Met Asn His Ala Cys Met Leu Phe Val Glu Asn Tyr
 385                 390                 395                 400
 Gly Gln Lys Ile Ile Lys Lys Asn Leu Cys Arg Asn Phe Met Leu His
                 405                 410                 415    
 Leu Val Ser Met His Asp Phe Asn Leu Ile Ser Ile Met Ser Ile Asp
             420                 425                 430        
 Lys Ala Val Thr Lys Leu Arg Glu Met Gln Gln Lys Leu Glu Lys Gly
         435                 440                 445            
 Glu Ser Ala Ser Pro Ala Asn Glu Glu Ile Thr Glu Glu Gln Asn Gly
     450                 455                 460                
 Thr Ala Asn Gly Phe Ser Glu Ile Asn Ser Lys Glu Lys Ala Leu Glu
 465                 470                 475                 480
 Thr Asp Ser Val Ser Gly Val Ser Lys Gln Ser Lys Lys Gln Lys Leu
                 485                 490                 495    





      <210> 1139
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 1139
 Met Leu Gly Leu Leu Val Ala Leu Leu Ala Leu Gly Leu Ala Val Phe
   1               5                  10                  15    
 Ala Leu Leu Asp Val Trp Tyr Leu Val Arg Leu Pro Cys Ala Val Leu
              20                  25                  30        
 Arg Ala Arg Leu Leu Gln Pro Arg Val Arg Asp Leu Leu Ala Glu Gln
          35                  40                  45            
 Arg Phe Pro Gly Arg Val Leu Pro Ser Asp Leu Asp Leu Leu Leu His
      50                  55                  60                
 Met Asn Asn Ala Arg Tyr Leu Arg Glu Ala Asp Phe Ala Arg Val Ala
  65                  70                  75                  80
 His Leu Thr Arg Cys Gly Val Leu Gly Ala Leu Arg Glu Leu Arg Ala
                  85                  90                  95    
 His Thr Val Leu Ala Ala Ser Cys Ala Arg His Arg Arg Ser Leu Arg
             100                 105                 110        
 Leu Leu Glu Pro Phe Glu Val Glu Pro Pro Glu Leu Pro Ala Asp Leu
         115                 120                 125            
 Gln His Trp Ile Ser Tyr Asn Glu Ala Ser Ser Gln Leu Leu Arg Met
     130                 135                 140                
 Glu Ser Gly Leu Ser Asp Val Thr Lys Asp Gln
 145                 150                 155



      <210> 1140
      <211> 169
      <212> PRT
      <213> Homo sapiens


      <400> 1140
 Met Ser Glu Arg Val Glu Arg Asn Trp Ser Thr Gly Gly Trp Leu Leu
   1               5                  10                  15    
 Ala Leu Cys Leu Ala Trp Leu Trp Thr His Leu Thr Leu Ala Ala Leu
              20                  25                  30        
 Gln Pro Pro Thr Ala Thr Val Leu Val Gln Gln Gly Thr Cys Glu Val
          35                  40                  45            
 Ile Ala Ala His Arg Cys Cys Asn Arg Asn Arg Ile Glu Glu Arg Ser
      50                  55                  60                
 Gln Thr Val Lys Cys Ser Cys Phe Ser Gly Gln Val Ala Gly Thr Thr
  65                  70                  75                  80
 Arg Ala Lys Pro Ser Cys Val Asp Asp Leu Leu Leu Ala Ala His Cys
                  85                  90                  95    
 Ala Arg Arg Asp Pro Arg Ala Ala Leu Arg Leu Leu Leu Pro Gln Pro
             100                 105                 110        
 Pro Ser Ser Cys Arg Asp Gly Gly Val Arg Trp Ser Pro Ala Cys Arg
         115                 120                 125            
 Gly Arg Ser Val Arg Cys Ser Arg Thr Cys Arg Asp Gly Ala Ala Ala
     130                 135                 140                
 Val Asp Thr Lys Ser Lys Pro Pro Arg Ser His Asp Ser Ser Trp Gly
 145                 150                 155                 160
 Ser Arg Pro Gly Gln Glu Arg Leu Asp
                 165                



      <210> 1141
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 1141
 Met Ser Glu Arg Val Glu Arg Asn Trp Ser Thr Gly Gly Trp Leu Leu
   1               5                  10                  15    
 Ala Leu Cys Leu Ala Trp Leu Trp Thr His Leu Thr Leu Ala Ala Leu
              20                  25                  30        
 Gln Pro Pro Thr Ala Thr Val Leu Val Gln Gln Gly Thr Cys Glu Val
          35                  40                  45            
 Ile Ala Ala His Arg Cys Cys Asn Arg Asn Arg Ile Glu Glu Arg Ser
      50                  55                  60                
 Gln Thr Val Lys Cys Ser Cys Phe Ser Gly Gln Val Ala Gly Thr Thr
  65                  70                  75                  80
 Arg Ala Lys Pro Ser Cys Val Asp Ala Ser Ile Val Leu Gln Arg Trp
                  85                  90                  95    
 Trp Cys Gln Met Glu Pro Cys Leu Pro Gly Glu Glu Cys Lys Val Leu
             100                 105                 110        
 Pro Asp Leu Ser Gly Trp Ser Cys Ser Ser Gly His Lys Val Lys Thr
         115                 120                 125            
 Thr Lys Val Thr Arg
     130            



      <210> 1142
      <211> 430
      <212> PRT
      <213> Homo sapiens


      <400> 1142
 Met Gly Asp Ser Arg Arg Arg Ser Leu Gly Asn Gln Pro Ser Ser Glu
   1               5                  10                  15    
 Ala Ala Gly Arg Ser Glu Arg Glu Gln Asp Gly Asp Pro Arg Gly Leu
              20                  25                  30        
 Gln Ser Ser Val Tyr Glu Ser Arg Arg Val Thr Asp Pro Glu Arg Gln
          35                  40                  45            
 Asp Leu Asp Asn Ala Glu Leu Gly Pro Glu Asp Pro Glu Glu Glu Leu
      50                  55                  60                
 Pro Pro Glu Glu Val Ala Gly Glu Glu Phe Pro Glu Thr Leu Asp Pro
  65                  70                  75                  80
 Lys Glu Ala Leu Ser Glu Leu Glu Arg Val Leu Asp Lys Asp Leu Glu
                  85                  90                  95    
 Glu Asp Ile Pro Glu Ile Ser Pro Pro Ser Glu Thr Pro Arg Gly Lys
             100                 105                 110        
 Gly Glu Ala Gly Gly Gln Gly Glu Cys Arg Gln Lys Ala Leu Glu Gln
         115                 120                 125            
 Asp Pro Arg Phe Ser Gly Leu Pro Asn Ala Ser Gly Arg Glu Ser Ser
     130                 135                 140                
 Ser Asn Phe Asn Val Glu Phe Ser Gln Ser Arg Leu Ser Ile Ser Gln
 145                 150                 155                 160
 Lys Leu Pro Ser Thr Thr Met Thr Lys Ala Arg Lys Arg Arg Arg Arg
                 165                 170                 175    
 Arg Arg Leu Met Glu Leu Ala Glu Pro Lys Ile Asn Trp Gln Val Leu
             180                 185                 190        
 Lys Asp Arg Lys Gly Arg Cys Gly Lys Gly Tyr Ala Trp Ile Ser Pro
         195                 200                 205            
 Cys Lys Met Ser Leu His Phe Cys Leu Cys Trp Pro Ser Val Tyr Trp
     210                 215                 220                
 Thr Glu Arg Phe Leu Glu Asp Thr Thr Leu Thr Ile Thr Val Pro Ala
 225                 230                 235                 240
 Val Ser Arg Arg Val Glu Glu Leu Ser Arg Pro Lys Arg Phe Tyr Leu
                 245                 250                 255    
 Glu Tyr Tyr Asn Asn Asn Arg Thr Thr Pro Val Trp Pro Ile Pro Arg
             260                 265                 270        
 Ser Ser Leu Glu Tyr Arg Ala Ser Ser Arg Leu Lys Glu Leu Ala Ala
         275                 280                 285            
 Pro Lys Ile Arg Asp Asn Phe Trp Ser Met Pro Met Ser Glu Val Ser
     290                 295                 300                
 Gln Val Ser Arg Ala Ala Gln Met Ala Val Pro Ser Ser Arg Ile Leu
 305                 310                 315                 320
 Gln Leu Ser Lys Pro Lys Ala Pro Ala Thr Leu Leu Glu Glu Trp Asp
                 325                 330                 335    
 Pro Val Pro Lys Pro Lys Pro His Val Ser Asp His Asn Arg Leu Leu
             340                 345                 350        
 His Leu Ala Arg Pro Lys Ala Gln Ser Asp Lys Cys Val Pro Asp Arg
         355                 360                 365            
 Asp Pro Arg Trp Glu Val Leu Asp Val Thr Lys Lys Val Val Ala Ser
     370                 375                 380                
 Pro Arg Ile Ile Ser Leu Ala Lys Pro Lys Val Arg Lys Gly Leu Asn
 385                 390                 395                 400
 Glu Gly Tyr Asp Arg Arg Pro Leu Ala Ser Met Ser Leu Pro Pro Pro
                 405                 410                 415    
 Lys Ala Ser Pro Glu Lys Cys Asp Gln Pro Arg Pro Gly Leu
             420                 425                 430



      <210> 1143
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 1143
 Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Phe
   1               5                  10                  15    
 Ile Ile Met Thr Trp Lys Val Cys Ile Thr Leu Ala Ile Thr Ser Trp
              20                  25                  30        
 Thr Cys Gly Ser Leu Leu Ala Met Val His Val Ser Leu Ile Leu Arg
          35                  40                  45            
 Leu Pro Phe Cys Gly Pro Arg Glu Ile Asn His Phe Phe Cys Glu Ile
      50                  55                  60                
 Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp Leu Asn Gln Val
  65                  70                  75                  80
 Val Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly Pro Leu Cys Leu
                  85                  90                  95    
 Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile Leu Arg Ile Gln
             100                 105                 110        
 Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser His Leu
         115                 120                 125            
 Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val Met Tyr Met Ala
     130                 135                 140                
 Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val Leu Phe Leu Phe
 145                 150                 155                 160
 Tyr Ser Ser Phe Asn Pro Met Leu Asn Pro Leu Ile Tyr Asn Leu Arg
                 165                 170                 175    
 Asn Val Glu Val Lys Gly Ala Leu Arg Arg Ala Leu Cys Lys Glu Ser
             180                 185                 190        
 His Ser
        



      <210> 1144
      <211> 308
      <212> PRT
      <213> Homo sapiens


      <400> 1144
 Met Val Lys Asn Gln Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe
   1               5                  10                  15    
 Leu Leu Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu
              20                  25                  30        
 Phe Tyr Ile Phe Thr Leu Leu Gly Asn Gly Ala Ile Leu Gly Leu Ile
          35                  40                  45            
 Ser Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His
      50                  55                  60                
 Leu Ala Val Val Asp Ile Ala Tyr Thr Arg Asn Thr Val Pro Gln Met
  65                  70                  75                  80
 Leu Ala Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys
                  85                  90                  95    
 Met Thr Gln Thr Phe Leu Cys Leu Ser Phe Gly His Ser Glu Cys Leu
             100                 105                 110        
 Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro
         115                 120                 125            
 Leu Arg Tyr Ser Val Ile Met Thr Cys Cys Ile Thr Leu Ala Ile Thr
     130                 135                 140                
 Ser Trp Thr Cys Gly Ser Leu Leu Ala Met Val His Val Ser Leu Ile
 145                 150                 155                 160
 Leu Arg Leu Pro Phe Cys Gly Pro Arg Glu Ile Asn His Phe Phe Cys
                 165                 170                 175    
 Glu Ile Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp Leu Asn
             180                 185                 190        
 Gln Val Val Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly Pro Leu
         195                 200                 205            
 Cys Leu Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile Leu Arg
     210                 215                 220                
 Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser
 225                 230                 235                 240
 His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val Met Tyr
                 245                 250                 255    
 Met Ala Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val Leu Phe
             260                 265                 270        
 Leu Phe Tyr Ser Ser Phe Asn Pro Met Leu Asn Pro Leu Ile Tyr Asn
         275                 280                 285            
 Leu Arg Asn Val Glu Val Lys Gly Ala Leu Arg Arg Ala Leu Cys Lys
     290                 295                 300                
 Glu Ser His Ser
 305            



      <210> 1145
      <211> 108
      <212> PRT
      <213> Homo sapiens


      <400> 1145
 Met Ile Val Met Ala Phe Ser Leu Lys Ala Ile Phe Leu Leu Phe Pro
   1               5                  10                  15    
 Leu Lys Ser His Pro Ala Phe Pro Val His Tyr Pro Ser Gln Thr Thr
              20                  25                  30        
 Ser Cys Ser Asn Met Asp Ala Gln Pro Gly Ala Ala Ala Ala Arg Met
          35                  40                  45            
 Thr Trp Ser Gln Gly Gly Leu Arg Asn Arg Cys Thr Pro Phe Leu Gly
      50                  55                  60                
 Asp Val Phe Gly Phe Val Arg Asn Leu Thr Ile Lys His Asp Gly Gln
  65                  70                  75                  80
 Gln Arg Tyr Gln Gln Asp Arg Ser Ser Leu His Glu Leu Pro Cys Ile
                  85                  90                  95    
 His Trp Glu Ser Gln His Ser Cys Gly Gln Glu Ile
             100                 105            



      <210> 1146
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 1146
 Met Ser Glu Tyr Gly Arg Met Thr Asp Thr Glu Arg Asp Gln Ile Asp
   1               5                  10                  15    
 Gln Asp Ala Gln Ile Phe Met Arg Thr Cys Ser Glu Ala Ile Gln Gln
              20                  25                  30        
 Leu Arg Thr Glu Ala His Lys Glu Ile His Ser Gln Gln Val Lys Glu
          35                  40                  45            
 His Arg Thr Ala Val Leu Asp Phe Ile Glu Asp Tyr Leu Lys Arg Val
      50                  55                  60                
 Cys Lys Leu Tyr Ser Glu Gln Arg Ala Ile Arg Val Lys Arg Val Val
  65                  70                  75                  80
 Asp Lys Lys Arg Leu Ser Lys Leu Glu Pro Glu Pro Asn Thr Lys Thr
                  85                  90                  95    
 Arg Glu Ser Thr Ser Ser Glu Lys Val Ser Gln Ser Pro Ser Lys Asp
             100                 105                 110        
 Ser Glu Glu Asn Pro Ala Thr Glu Glu Arg Pro Glu Lys Ile Leu Ala
         115                 120                 125            
 Glu Thr Gln Pro Glu Leu Gly Thr Trp Gly Asp Gly Lys Gly Glu Asp
     130                 135                 140                
 Glu Leu Ser Pro Glu Glu Ile Gln Met Phe Glu Gln Glu Asn Gln Arg
 145                 150                 155                 160
 Leu Ile Gly Glu Met Asn Ser Leu Phe Asp Glu Val Arg Gln Ile Glu
                 165                 170                 175    
 Gly Arg Val Val Glu Ile Ser Arg Leu Gln Glu Ile Phe Thr Glu Lys
             180                 185                 190        
 Val Leu Gln Gln Glu Ala Glu Ile Asp Ser Ile His Gln Leu Val Val
         195                 200                 205            
 Gly Ala Thr Glu Asn Ile Lys Glu Gly Asn Glu Asp Ile Arg Glu Ala
     210                 215                 220                
 Ile Lys Asn Asn Ala Gly Phe Arg Val Trp Ile Leu Phe Phe Leu Val
 225                 230                 235                 240
 Met Cys Ser Phe Ser Leu Leu Phe Leu Asp Trp Tyr Asp Ser
                 245                 250                



      <210> 1147
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 1147
 Met Cys Ser Leu Pro Met Ala Arg Tyr Tyr Ile Ile Lys Tyr Ala Asp
   1               5                  10                  15    
 Gln Lys Ala Leu Tyr Thr Arg Asp Gly Gln Leu Leu Val Gly Asp Pro
              20                  25                  30        
 Val Ala Asp Asn Cys Cys Ala Glu Lys Ile Cys Ile Leu Pro Asn Arg
          35                  40                  45            
 Gly Leu Asp Arg Thr Lys Val Pro Ile Phe Leu Gly Ile Gln Gly Gly
      50                  55                  60                
 Ser Arg Cys Leu Ala Cys Val Glu Thr Glu Glu Gly Pro Ser Leu Gln
  65                  70                  75                  80
 Leu Glu Asp Val Asn Ile Glu Glu Leu Tyr Lys Gly Gly Glu Glu Ala
                  85                  90                  95    
 Thr Arg Phe Thr Phe Phe Gln Ser Ser Ser Gly Ser Ala Phe Arg Leu
             100                 105                 110        
 Glu Ala Ala Ala Trp Pro Gly Trp Phe Leu Cys Gly Pro Ala Glu Pro
         115                 120                 125            
 Gln Gln Pro Val Gln Leu Thr Lys Glu Ser Glu Pro Ser Ala Arg Thr
     130                 135                 140                
 Lys Phe Tyr Phe Glu Gln Ser Trp
 145                 150        



      <210> 1148
      <211> 507
      <212> PRT
      <213> Homo sapiens


      <400> 1148
 Met Gln Phe Leu Asn Asp Arg Leu Ala Ser Tyr Leu Glu Lys Val Arg
   1               5                  10                  15    
 Ser Leu Glu Glu Thr Asn Ala Glu Leu Glu Ser Arg Ile Gln Glu Gln
              20                  25                  30        
 Cys Glu Gln Asp Ile Pro Met Val Cys Pro Asp Tyr Gln Arg Tyr Phe
          35                  40                  45            
 Asn Thr Ile Glu Asp Leu Gln Gln Lys Ile Leu Cys Thr Lys Ala Glu
      50                  55                  60                
 Asn Ser Arg Leu Ala Val Gln Leu Asp Asn Cys Lys Leu Ala Thr Asp
  65                  70                  75                  80
 Asp Phe Lys Ser Lys Tyr Glu Ser Glu Leu Ser Leu Arg Gln Leu Leu
                  85                  90                  95    
 Glu Ala Asp Ile Ser Ser Leu His Gly Ile Leu Glu Glu Leu Thr Leu
             100                 105                 110        
 Cys Lys Ser Asp Leu Glu Ala His Val Glu Ser Leu Lys Glu Asp Leu
         115                 120                 125            
 Leu Cys Leu Lys Lys Asn His Glu Glu Glu Val Asn Leu Leu Arg Glu
     130                 135                 140                
 Gln Leu Gly Asp Arg Leu Ser Val Glu Leu Asp Thr Ala Pro Thr Leu
 145                 150                 155                 160
 Asp Leu Asn Arg Val Leu Asp Glu Met Arg Cys Gln Cys Glu Thr Val
                 165                 170                 175    
 Leu Ala Asn Asn Arg Arg Glu Ala Glu Glu Trp Leu Ala Val Gln Thr
             180                 185                 190        
 Glu Glu Leu Asn Gln Gln Gln Leu Ser Ser Ala Glu Gln Leu Gln Gly
         195                 200                 205            
 Cys Gln Met Glu Ile Leu Glu Leu Lys Arg Thr Ala Ser Ala Leu Glu
     210                 215                 220                
 Ile Glu Leu Gln Ala Gln Gln Ser Leu Thr Glu Ser Leu Glu Cys Thr
 225                 230                 235                 240
 Val Ala Glu Thr Glu Ala Gln Tyr Ser Ser Gln Leu Ala Gln Ile Gln
                 245                 250                 255    
 Cys Leu Ile Asp Asn Leu Glu Asn Gln Leu Ala Glu Ile Arg Cys Asp
             260                 265                 270        
 Leu Glu Arg Gln Asn Gln Glu Tyr Gln Val Leu Leu Asp Val Lys Ala
         275                 280                 285            
 Arg Leu Glu Gly Glu Ile Asn Thr Ser Thr Lys Ala Thr Pro Met Gln
     290                 295                 300                
 Cys Gln Trp Lys Leu His Gly Ser Asn Asn Lys Ile Phe Leu Pro Leu
 305                 310                 315                 320
 Leu Ala Arg Val Val Ser Ala Glu Ala Arg Phe Gly Asn Glu Lys Lys
                 325                 330                 335    
 Ala Glu Ala Thr Phe Met Glu Glu Val Pro His Gly Tyr Gly Ser Asp
             340                 345                 350        
 Ile Pro Ile Tyr Leu Met Asn Asn Phe Asn Ala Arg Phe Ser Leu Asp
         355                 360                 365            
 Asp Cys Ser Trp Tyr Gly Glu Gly Ile Asn Ser Asn Glu Lys Glu Thr
     370                 375                 380                
 Met Gln Ile Leu Asn Glu Arg Leu Ala Asn Tyr Leu Gln Lys Val Arg
 385                 390                 395                 400
 Met Leu Glu Arg Glu Asn Ala Glu Leu Glu Ser Lys Ile Gln Glu Glu
                 405                 410                 415    
 Ser Asn Lys Glu Leu Pro Val Leu Cys Pro Asp Tyr Leu Ser Tyr Tyr
             420                 425                 430        
 Thr Thr Ile Glu Glu Leu Gln Gln Lys Ile Leu Cys Thr Lys Ala Glu
         435                 440                 445            
 Asn Ser Arg Leu Val Ser Gln Ile Asp Asn Thr Lys Leu Thr Ala Asp
     450                 455                 460                
 Asp Leu Arg Ala Lys Ala His Pro Glu Ser Asp Arg Asp Ala Leu Asn
 465                 470                 475                 480
 Lys Ile Val Pro Met Ser Thr Asn Pro Leu Ala Pro Asp Asp Val Gly
                 485                 490                 495    
 Thr Ser Pro Glu Lys Thr Phe Lys Phe Asn Glu
             500                 505        



      <210> 1149
      <211> 319
      <212> PRT
      <213> Homo sapiens


      <400> 1149
 Met Ala Pro Gln Arg Arg Ala Ala Thr Lys Ala Pro Glu Gly Asn Gly
   1               5                  10                  15    
 Ala Ala Glu Arg Arg Asn Arg Ser Ser Thr Lys Lys Asp Arg Ala Pro
              20                  25                  30        
 Arg Glu Val Gln Arg Leu Trp Gln Arg Pro Trp Leu Arg Thr Ala Gly
          35                  40                  45            
 Leu Gly Ala Gly Phe Val Leu Thr Ala Leu Leu Leu Trp Ser Ser Leu
      50                  55                  60                
 Gly Ala Asp Asp Gly Val Ala Glu Val Leu Ala Arg Arg Gly Glu Val
  65                  70                  75                  80
 Val Ala Gly Arg Phe Ile Glu Val Pro Cys Ser Glu Asp Tyr Asp Ser
                  85                  90                  95    
 His Arg Arg Phe Glu Gly Cys Thr Pro Arg Lys Cys Gly Arg Gly Val
             100                 105                 110        
 Thr Asp Val Val Ile Thr Arg Glu Glu Ala Glu Arg Ile Arg Ser Val
         115                 120                 125            
 Ala Glu Lys Gly Leu Ser Leu Gly Gly Ser Asp Gly Gly Ala Ser Ile
     130                 135                 140                
 Leu Asp Leu His Ser Gly Ala Leu Ser Val Gly Lys His Phe Val Asn
 145                 150                 155                 160
 Leu Tyr Arg Tyr Phe Gly Asp Lys Ile Gln Asn Ile Phe Ser Glu Glu
                 165                 170                 175    
 Asp Phe Arg Leu Tyr Arg Glu Val Arg Gln Lys Val Gln Leu Thr Ile
             180                 185                 190        
 Ala Glu Ala Phe Gly Ile Ser Ala Ser Ser Leu His Leu Thr Lys Pro
         195                 200                 205            
 Thr Phe Phe Ser Arg Ile Asn Ser Thr Glu Ala Arg Thr Ala His Asp
     210                 215                 220                
 Glu Tyr Trp His Ala His Val Asp Lys Val Thr Tyr Gly Ser Phe Asp
 225                 230                 235                 240
 Tyr Thr Ser Leu Leu Tyr Leu Ser Asn Tyr Leu Glu Asp Phe Gly Gly
                 245                 250                 255    
 Gly Arg Phe Met Phe Met Glu Glu Gly Ala Asn Lys Thr Val Glu Pro
             260                 265                 270        
 Arg Ala Gly Arg Val Ser Phe Phe Thr Ser Gly Ser Glu Asn Leu His
         275                 280                 285            
 Arg Val Glu Lys Val His Trp Gly Thr Arg Tyr Ala Ile Thr Ile Ala
     290                 295                 300                
 Phe Ser Cys Asn Pro Asp His Gly Ile Glu Asp Pro Ala Phe Pro
 305                 310                 315                



      <210> 1150
      <211> 322
      <212> PRT
      <213> Homo sapiens


      <400> 1150
 Met Ser Pro Glu Glu Trp Thr Tyr Leu Val Val Leu Leu Ile Ser Ile
   1               5                  10                  15    
 Pro Ile Gly Phe Leu Phe Lys Lys Ala Gly Pro Gly Leu Lys Arg Trp
              20                  25                  30        
 Gly Ala Ala Ala Val Gly Leu Gly Leu Thr Leu Phe Thr Cys Gly Pro
          35                  40                  45            
 His Thr Leu His Ser Leu Val Thr Ile Leu Gly Thr Trp Ala Leu Ile
      50                  55                  60                
 Gln Ala Gln Pro Cys Pro Cys His Ala Leu Ala Leu Ala Trp Thr Phe
  65                  70                  75                  80
 Ser Tyr Leu Leu Phe Phe Arg Ala Leu Ser Leu Leu Gly Leu Pro Thr
                  85                  90                  95    
 Pro Thr Pro Phe Thr Asn Ala Val Gln Leu Leu Leu Thr Leu Lys Leu
             100                 105                 110        
 Val Ser Leu Ala Ser Glu Val Gln Asp Leu His Leu Ala Gln Arg Lys
         115                 120                 125            
 Glu Met Ala Ser Gly Phe Ser Lys Gly Pro Thr Leu Gly Leu Leu Pro
     130                 135                 140                
 Asp Val Pro Ser Leu Met Glu Thr Leu Ser Tyr Ser Tyr Cys Tyr Val
 145                 150                 155                 160
 Gly Ile Met Thr Gly Pro Phe Phe Arg Tyr Arg Thr Tyr Leu Asp Trp
                 165                 170                 175    
 Leu Glu Gln Pro Phe Pro Gly Ala Val Pro Ser Leu Arg Pro Leu Leu
             180                 185                 190        
 Arg Arg Ala Trp Pro Ala Pro Leu Phe Gly Leu Leu Phe Leu Leu Ser
         195                 200                 205            
 Ser His Leu Phe Pro Leu Glu Ala Val Arg Glu Asp Ala Phe Tyr Ala
     210                 215                 220                
 Arg Pro Leu Pro Ala Arg Leu Phe Tyr Met Ile Pro Val Phe Phe Ala
 225                 230                 235                 240
 Phe Arg Met Arg Phe Tyr Val Ala Trp Ile Ala Ala Ala Leu Arg Pro
                 245                 250                 255    
 Ala Leu Pro Pro Ala Leu Gly Pro Thr Pro Trp Pro Pro Lys Pro Gly
             260                 265                 270        
 Pro Glu Ala Ala Pro Pro Ser Asn Ala His Pro Pro Ala Val Arg Arg
         275                 280                 285            
 Arg Arg Leu Pro Trp Ser Met Thr Met Arg Pro Ser Ala Thr Ser Thr
     290                 295                 300                
 Ala Thr Ala Gln Ile Ser Ala Cys Gly Cys Ala Met Ala Cys Gly Thr
 305                 310                 315                 320
 Gly Thr
        



      <210> 1151
      <211> 508
      <212> PRT
      <213> Homo sapiens


      <400> 1151
 Met Ser Arg Gln Phe Thr Tyr Lys Ser Gly Ala Ala Ala Lys Gly Gly
   1               5                  10                  15    
 Phe Ser Gly Cys Ser Ala Val Leu Ser Gly Gly Ser Ser Ser Ser Tyr
              20                  25                  30        
 Arg Ala Gly Gly Lys Gly Leu Ser Gly Gly Phe Ser Ser Arg Ser Leu
          35                  40                  45            
 Tyr Ser Leu Gly Gly Ala Arg Ser Ile Ser Phe Asn Val Ala Ser Gly
      50                  55                  60                
 Ser Gly Trp Ala Gly Gly Tyr Gly Phe Gly Arg Gly Arg Ala Ser Gly
  65                  70                  75                  80
 Phe Ala Gly Ser Met Phe Gly Ser Val Ala Leu Gly Ser Val Cys Pro
                  85                  90                  95    
 Ser Leu Cys Pro Pro Gly Gly Ile His Gln Val Thr Ile Asn Lys Ser
             100                 105                 110        
 Leu Leu Ala Pro Leu Asn Val Glu Leu Asp Pro Glu Ile Gln Lys Val
         115                 120                 125            
 Arg Ala Gln Glu Arg Glu Gln Ile Lys Val Leu Asn Asn Lys Phe Ala
     130                 135                 140                
 Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Gln Val Leu
 145                 150                 155                 160
 Glu Thr Lys Trp Glu Leu Leu Gln Gln Leu Asp Leu Asn Asn Cys Lys
                 165                 170                 175    
 Asn Asn Leu Glu Pro Ile Leu Glu Gly Tyr Ile Ser Asn Leu Arg Lys
             180                 185                 190        
 Gln Leu Glu Thr Leu Ser Gly Asp Arg Val Arg Leu Asp Ser Glu Leu
         195                 200                 205            
 Arg Ser Val Arg Glu Val Val Glu Asp Tyr Lys Lys Arg Tyr Glu Glu
     210                 215                 220                
 Glu Ile Asn Lys Arg Thr Thr Ala Glu Asn Glu Phe Val Val Leu Lys
 225                 230                 235                 240
 Lys Glu Thr Ala Gln Ile Gln Ser His Ile Ser Asp Thr Ser Ile Ile
                 245                 250                 255    
 Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala
             260                 265                 270        
 Glu Val Arg Ala Gln Tyr Glu Glu Ile Ala Arg Lys Ser Lys Ala Glu
         275                 280                 285            
 Ala Glu Ala Leu Tyr Gln Thr Lys Phe Gln Glu Leu Gln Leu Ala Ala
     290                 295                 300                
 Gly Arg His Gly Asp Asp Leu Lys His Thr Lys Asn Glu Ile Ser Glu
 305                 310                 315                 320
 Leu Thr Arg Leu Ile Gln Arg Leu Arg Ser Glu Ile Glu Ser Val Lys
                 325                 330                 335    
 Lys Gln Cys Ala Asn Leu Glu Thr Ala Ile Ala Asp Ala Glu Gln Arg
             340                 345                 350        
 Gly Asp Cys Ala Leu Lys Asp Ala Arg Ala Lys Leu Asp Glu Leu Glu
         355                 360                 365            
 Gly Ala Leu Gln Gln Ala Lys Glu Glu Leu Ala Arg Met Leu Arg Glu
     370                 375                 380                
 Tyr Gln Glu Leu Leu Ser Val Lys Leu Ser Leu Asp Ile Glu Ile Ala
 385                 390                 395                 400
 Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Met Ser Gly Glu
                 405                 410                 415    
 Tyr Thr Asn Ser Val Ser Ile Ser Val Ile Asn Ser Ser Met Ala Gly
             420                 425                 430        
 Met Ala Gly Thr Gly Ala Gly Phe Gly Phe Ser Asn Ala Gly Thr Tyr
         435                 440                 445            
 Gly Tyr Trp Pro Ser Ser Val Ser Gly Gly Tyr Ser Met Leu Pro Gly
     450                 455                 460                
 Gly Cys Val Thr Gly Ser Gly Asn Cys Ser Pro Arg Gly Glu Ala Arg
 465                 470                 475                 480
 Thr Arg Leu Gly Ser Ala Ser Glu Phe Arg Asp Ser Gln Gly Lys Thr
                 485                 490                 495    
 Leu Ala Leu Ser Ser Pro Thr Lys Lys Thr Met Arg
             500                 505            



      <210> 1152
      <211> 459
      <212> PRT
      <213> Homo sapiens


      <400> 1152
 Met Lys Arg Leu Leu Leu Leu Phe Leu Phe Phe Ile Thr Phe Ser Ser
   1               5                  10                  15    
 Ala Phe Pro Leu Gly Arg Met Met Glu Asn Glu Glu Asn Met Gln Leu
              20                  25                  30        
 Ala Gln Ala Tyr Leu Asn Gln Phe Tyr Ser Leu Glu Ile Glu Gly Asn
          35                  40                  45            
 His Leu Val Gln Ser Lys Asn Arg Ser Leu Ile Asp Asp Lys Ile Arg
      50                  55                  60                
 Glu Met Gln Ala Phe Phe Gly Leu Thr Val Thr Gly Lys Leu Asp Ser
  65                  70                  75                  80
 Asn Thr Leu Glu Ile Met Lys Thr Pro Arg Cys Gly Val Pro Asp Val
                  85                  90                  95    
 Gly Gln Tyr Gly Tyr Thr Leu Pro Gly Trp Arg Lys Tyr Asn Leu Thr
             100                 105                 110        
 Tyr Arg Ile Ile Asn Tyr Thr Pro Asp Met Ala Arg Ala Ala Val Asp
         115                 120                 125            
 Glu Ala Ile Gln Glu Gly Leu Glu Val Trp Ser Lys Val Thr Pro Leu
     130                 135                 140                
 Lys Phe Thr Lys Ile Ser Lys Gly Ile Ala Asp Ile Met Ile Ala Phe
 145                 150                 155                 160
 Arg Thr Arg Val His Gly Arg Cys Pro Arg Tyr Phe Asp Gly Pro Leu
                 165                 170                 175    
 Gly Val Leu Gly His Ala Phe Pro Pro Gly Pro Gly Leu Gly Gly Asp
             180                 185                 190        
 Thr His Phe Asp Glu Asp Glu Asn Cys Thr Lys Asp Gly Ala Gly Gly
         195                 200                 205            
 Leu Pro Lys Glu Pro Ala Lys Pro Lys Glu Pro Thr Ile Pro His Ala
     210                 215                 220                
 Cys Asp Pro Asp Leu Thr Phe Asp Ala Ile Thr Thr Phe Arg Arg Glu
 225                 230                 235                 240
 Val Met Phe Phe Lys Gly Arg His Leu Trp Arg Ile Tyr Tyr Asp Ile
                 245                 250                 255    
 Thr Asp Val Glu Phe Glu Leu Ile Ala Ser Phe Trp Pro Ser Leu Pro
             260                 265                 270        
 Ala Asp Leu Gln Ala Ala Tyr Glu Asn Pro Arg Asp Lys Ile Leu Val
         275                 280                 285            
 Phe Lys Asp Glu Asn Phe Trp Met Ile Arg Gly Tyr Ala Val Leu Pro
     290                 295                 300                
 Asp Tyr Pro Lys Ser Ile His Thr Leu Gly Phe Pro Gly Arg Val Lys
 305                 310                 315                 320
 Lys Ile Asp Ala Ala Val Cys Asp Lys Thr Thr Arg Lys Thr Tyr Phe
                 325                 330                 335    
 Phe Val Gly Ile Trp Cys Trp Arg Phe Asp Glu Met Thr Gln Thr Met
             340                 345                 350        
 Asp Lys Gly Phe Pro Gln Arg Val Val Lys His Phe Pro Gly Ile Ser
         355                 360                 365            
 Ile Arg Val Asp Ala Ala Phe Gln Tyr Lys Gly Phe Phe Phe Phe Ser
     370                 375                 380                
 Arg Gly Ser Lys Gln Phe Glu Tyr Asp Ile Lys Thr Lys Asn Ile Thr
 385                 390                 395                 400
 Arg Ile Met Arg Thr Asn Thr Trp Phe Gln Cys Lys Glu Pro Lys Asn
                 405                 410                 415    
 Ser Ser Phe Gly Phe Asp Ile Asn Lys Glu Lys Ala His Ser Gly Gly
             420                 425                 430        
 Ile Lys Ile Leu Tyr His Lys Ser Leu Ser Leu Phe Ile Phe Gly Ile
         435                 440                 445            
 Val His Leu Leu Lys Asn Thr Ser Ile Tyr Gln
     450                 455                



      <210> 1153
      <211> 459
      <212> PRT
      <213> Homo sapiens


      <400> 1153
 Met Lys Arg Leu Leu Leu Leu Phe Leu Phe Phe Ile Thr Phe Ser Ser
   1               5                  10                  15    
 Ala Phe Pro Leu Gly Arg Met Met Glu Asn Glu Glu Asn Met Gln Leu
              20                  25                  30        
 Ala Gln Ala Tyr Leu Asn Gln Phe Tyr Ser Leu Glu Ile Glu Gly Asn
          35                  40                  45            
 His Leu Val Gln Ser Lys Asn Arg Ser Leu Ile Asp Asp Lys Ile Arg
      50                  55                  60                
 Glu Met Gln Ala Phe Phe Gly Leu Thr Val Thr Gly Lys Leu Asp Ser
  65                  70                  75                  80
 Asn Thr Leu Glu Ile Met Lys Thr Pro Arg Cys Gly Val Pro Asp Val
                  85                  90                  95    
 Gly Gln Tyr Gly Tyr Thr Leu Pro Gly Trp Arg Lys Tyr Asn Leu Thr
             100                 105                 110        
 Tyr Arg Ile Ile Asn Tyr Thr Pro Asp Met Ala Arg Ala Ala Val Asp
         115                 120                 125            
 Glu Ala Ile Gln Glu Gly Leu Glu Val Trp Ser Lys Val Thr Pro Leu
     130                 135                 140                
 Lys Phe Thr Lys Ile Ser Lys Gly Ile Ala Asp Ile Met Ile Ala Phe
 145                 150                 155                 160
 Arg Thr Arg Val His Gly Arg Cys Pro Arg Tyr Phe Asp Gly Pro Leu
                 165                 170                 175    
 Gly Val Leu Gly His Ala Phe Pro Pro Gly Pro Gly Leu Gly Gly Asp
             180                 185                 190        
 Thr His Phe Asp Glu Asp Glu Asn Cys Thr Lys Asp Gly Ala Gly Gly
         195                 200                 205            
 Leu Pro Lys Glu Pro Ala Lys Pro Lys Glu Pro Thr Ile Pro His Ala
     210                 215                 220                
 Cys Asp Pro Asp Leu Thr Phe Asp Ala Ile Thr Thr Phe Arg Arg Glu
 225                 230                 235                 240
 Val Met Phe Phe Lys Gly Arg His Leu Trp Arg Ile Tyr Tyr Asp Ile
                 245                 250                 255    
 Thr Asp Val Glu Phe Glu Leu Ile Ala Ser Phe Trp Pro Ser Leu Pro
             260                 265                 270        
 Ala Asp Leu Gln Ala Ala Tyr Glu Asn Pro Arg Asp Lys Ile Leu Val
         275                 280                 285            
 Phe Lys Asp Glu Asn Phe Trp Met Ile Arg Gly Tyr Ala Val Leu Pro
     290                 295                 300                
 Asp Tyr Pro Lys Ser Ile His Thr Leu Gly Phe Pro Gly Arg Val Lys
 305                 310                 315                 320
 Lys Ile Asp Ala Ala Val Cys Asp Lys Thr Thr Arg Lys Thr Tyr Phe
                 325                 330                 335    
 Phe Val Gly Ile Trp Cys Trp Arg Phe Asp Glu Met Thr Gln Thr Met
             340                 345                 350        
 Asp Lys Gly Phe Pro Gln Arg Val Val Lys His Phe Pro Gly Ile Ser
         355                 360                 365            
 Ile Arg Val Asp Ala Ala Phe Gln Tyr Lys Gly Phe Phe Phe Phe Ser
     370                 375                 380                
 Arg Gly Ser Lys Gln Phe Glu Tyr Asp Ile Lys Thr Lys Asn Ile Thr
 385                 390                 395                 400
 Arg Ile Met Arg Thr Asn Thr Trp Phe Gln Cys Lys Glu Pro Lys Asn
                 405                 410                 415    
 Ser Ser Phe Gly Phe Asp Ile Asn Lys Glu Lys Ala His Ser Gly Gly
             420                 425                 430        
 Ile Lys Ile Leu Tyr His Lys Ser Leu Ser Leu Phe Ile Phe Gly Ile
         435                 440                 445            
 Val His Leu Leu Lys Asn Thr Ser Ile Tyr Gln
     450                 455                



      <210> 1154
      <211> 484
      <212> PRT
      <213> Homo sapiens


      <400> 1154
 Met Ala Glu Leu Arg Pro Ser Gly Ala Pro Gly Pro Thr Ala Pro Pro
   1               5                  10                  15    
 Ala Pro Gly Pro Thr Ala Pro Pro Ala Phe Ala Ser Leu Phe Pro Pro
              20                  25                  30        
 Gly Leu His Ala Ile Tyr Gly Glu Cys Arg Arg Leu Tyr Pro Asp Gln
          35                  40                  45            
 Pro Asn Pro Leu Gln Val Thr Ala Ile Val Lys Tyr Trp Leu Gly Gly
      50                  55                  60                
 Pro Asp Pro Leu Asp Tyr Val Ser Met Tyr Arg Asn Val Gly Ser Pro
  65                  70                  75                  80
 Ser Ala Asn Ile Pro Glu His Trp His Tyr Ile Ser Phe Gly Leu Ser
                  85                  90                  95    
 Asp Leu Tyr Gly Asp Asn Arg Val His Glu Phe Thr Gly Thr Asp Gly
             100                 105                 110        
 Pro Ser Gly Phe Gly Phe Glu Leu Thr Phe Arg Leu Lys Arg Glu Thr
         115                 120                 125            
 Gly Glu Ser Ala Pro Pro Thr Trp Pro Ala Glu Leu Met Gln Gly Leu
     130                 135                 140                
 Ala Arg Tyr Val Phe Gln Ser Glu Asn Thr Phe Cys Ser Gly Asp His
 145                 150                 155                 160
 Val Ser Trp His Ser Pro Leu Asp Asn Ser Glu Ser Arg Ile Gln His
                 165                 170                 175    
 Met Leu Leu Thr Glu Asp Pro Gln Met Gln Pro Val Gln Thr Pro Phe
             180                 185                 190        
 Gly Val Val Thr Phe Leu Gln Ile Val Gly Val Cys Thr Glu Glu Leu
         195                 200                 205            
 His Ser Ala Gln Gln Trp Asn Gly Gln Gly Ile Leu Glu Leu Leu Arg
     210                 215                 220                
 Thr Val Pro Ile Ala Gly Gly Pro Trp Leu Ile Thr Asp Met Arg Arg
 225                 230                 235                 240
 Gly Glu Thr Ile Phe Glu Ile Asp Pro His Leu Gln Glu Arg Val Asp
                 245                 250                 255    
 Lys Gly Ile Glu Thr Asp Gly Ser Asn Leu Ser Gly Val Ser Ala Lys
             260                 265                 270        
 Cys Ala Trp Asp Asp Leu Ser Arg Pro Pro Glu Asp Asp Glu Asp Ser
         275                 280                 285            
 Arg Ser Ile Cys Ile Gly Thr Gln Pro Arg Arg Leu Ser Gly Lys Asp
     290                 295                 300                
 Thr Glu Gln Ile Arg Glu Thr Leu Arg Arg Gly Leu Glu Ile Asn Ser
 305                 310                 315                 320
 Lys Pro Val Leu Pro Pro Ile Asn Pro Gln Arg Gln Asn Gly Leu Ala
                 325                 330                 335    
 His Asp Arg Ala Pro Ser Arg Lys Asp Ser Leu Glu Ser Asp Ser Ser
             340                 345                 350        
 Thr Ala Ile Ile Pro His Glu Leu Ile Arg Thr Arg Gln Leu Glu Ser
         355                 360                 365            
 Val His Leu Lys Phe Asn Gln Glu Ser Gly Ala Leu Ile Pro Leu Cys
     370                 375                 380                
 Leu Arg Gly Arg Leu Leu His Gly Arg His Phe Thr Tyr Lys Ser Ile
 385                 390                 395                 400
 Thr Gly Asp Met Ala Ile Thr Phe Val Ser Thr Gly Val Glu Gly Ala
                 405                 410                 415    
 Phe Ala Thr Glu Glu His Pro Tyr Ala Ala His Gly Pro Trp Leu Gln
             420                 425                 430        
 Ile Leu Leu Thr Glu Glu Phe Val Glu Lys Met Leu Glu Asp Leu Glu
         435                 440                 445            
 Asp Leu Thr Ser Pro Glu Glu Phe Lys Leu Pro Lys Glu Tyr Ser Trp
     450                 455                 460                
 Pro Glu Lys Lys Leu Lys Val Ser Ile Leu Pro Asp Val Val Phe Asp
 465                 470                 475                 480
 Ser Pro Leu His
                



      <210> 1155
      <211> 507
      <212> PRT
      <213> Homo sapiens


      <400> 1155
 Met Cys Thr Lys Thr Ile Pro Val Leu Trp Gly Cys Phe Leu Leu Trp
   1               5                  10                  15    
 Asn Leu Tyr Val Ser Ser Ser Gln Thr Ile Tyr Pro Gly Ile Lys Ala
              20                  25                  30        
 Arg Ile Thr Gln Arg Ala Leu Asp Tyr Gly Val Gln Ala Gly Met Lys
          35                  40                  45            
 Met Ile Glu Gln Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly
      50                  55                  60                
 Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe
  65                  70                  75                  80
 Ser Asn Ile Lys Ile Ser Ala Phe Ser Phe Pro Asn Thr Ser Leu Ala
                  85                  90                  95    
 Phe Val Pro Gly Val Gly Ile Lys Ala Leu Thr Asn His Gly Thr Ala
             100                 105                 110        
 Asn Ile Ser Thr Asp Trp Gly Phe Glu Ser Pro Leu Phe Gln Asp Thr
         115                 120                 125            
 Gly Gly Ala Asp Leu Phe Leu Ser Gly Val Tyr Phe Thr Gly Ile Ile
     130                 135                 140                
 Ile Leu Thr Arg Asn Asp Phe Gly His Pro Thr Leu Lys Leu Gln Asp
 145                 150                 155                 160
 Cys Tyr Ala Gln Leu Ser His Ala His Val Ser Phe Ser Gly Glu Leu
                 165                 170                 175    
 Ser Val Leu Tyr Asn Ser Phe Ala Glu Pro Met Glu Lys Pro Ile Leu
             180                 185                 190        
 Lys Asn Leu Asn Glu Met Leu Cys Pro Ile Ile Ala Ser Glu Val Lys
         195                 200                 205            
 Ala Leu Asn Ala Asn Leu Ser Thr Leu Glu Val Leu Thr Lys Ile Asp
     210                 215                 220                
 Asn Tyr Thr Leu Leu Asp Tyr Ser Leu Ile Ser Ser Pro Glu Ile Thr
 225                 230                 235                 240
 Glu Asn Tyr Leu Asp Leu Asn Leu Lys Gly Val Phe Tyr Pro Leu Glu
                 245                 250                 255    
 Asn Leu Thr Asp Pro Pro Phe Ser Pro Val Pro Phe Val Leu Pro Glu
             260                 265                 270        
 Arg Ser Asn Ser Met Leu Tyr Ile Gly Ile Ala Glu Tyr Phe Phe Lys
         275                 280                 285            
 Ser Ala Ser Phe Ala His Phe Thr Ala Gly Val Phe Asn Val Thr Leu
     290                 295                 300                
 Ser Thr Glu Glu Ile Ser Asn His Phe Val Gln Asn Ser Gln Gly Leu
 305                 310                 315                 320
 Gly Asn Val Leu Ser Arg Ile Ala Glu Ile Tyr Ile Leu Ser Gln Pro
                 325                 330                 335    
 Phe Met Val Arg Ile Met Ala Thr Glu Pro Pro Ile Ile Asn Leu Gln
             340                 345                 350        
 Pro Gly Asn Phe Thr Leu Asp Ile Pro Ala Ser Ile Met Met Leu Thr
         355                 360                 365            
 Gln Pro Lys Asn Ser Thr Val Glu Thr Ile Val Ser Met Asp Phe Val
     370                 375                 380                
 Ala Ser Thr Ser Val Gly Leu Val Ile Leu Gly Gln Arg Leu Val Cys
 385                 390                 395                 400
 Ser Leu Ser Leu Asn Arg Phe Arg Leu Ala Leu Pro Glu Ser Asn Arg
                 405                 410                 415    
 Ser Asn Ile Glu Val Leu Arg Phe Glu Asn Ile Leu Ser Ser Ile Leu
             420                 425                 430        
 His Phe Gly Val Leu Pro Leu Ala Asn Ala Lys Leu Gln Gln Gly Phe
         435                 440                 445            
 Pro Leu Ser Asn Pro His Lys Phe Leu Phe Val Asn Ser Asp Ile Glu
     450                 455                 460                
 Val Leu Glu Gly Phe Leu Leu Ile Ser Thr Asp Leu Lys Tyr Glu Thr
 465                 470                 475                 480
 Ser Ser Lys Gln Gln Pro Ser Phe His Val Trp Glu Gly Leu Asn Leu
                 485                 490                 495    
 Ile Ser Arg Gln Trp Arg Gly Lys Ser Ala Pro
             500                 505        



      <210> 1156
      <211> 384
      <212> PRT
      <213> Homo sapiens


      <400> 1156
 Met Gln Arg Ser Pro Pro Gly Tyr Gly Ala Gln Asp Asp Pro Pro Ala
   1               5                  10                  15    
 Arg Arg Asp Cys Ala Trp Ala Pro Gly His Gly Ala Ala Ala Asp Thr
              20                  25                  30        
 Arg Gly Leu Ala Ala Gly Pro Ala Ala Leu Ala Ala Pro Ala Ala Pro
          35                  40                  45            
 Ala Ser Pro Pro Ser Pro Gln Arg Ser Pro Pro Arg Ser Pro Glu Pro
      50                  55                  60                
 Gly Arg Tyr Gly Leu Ser Pro Ala Gly Arg Gly Glu Arg Gln Ala Ala
  65                  70                  75                  80
 Asp Glu Ser Arg Ile Arg Arg Pro Met Asn Ala Phe Met Val Trp Ala
                  85                  90                  95    
 Lys Asp Glu Arg Lys Arg Leu Ala Gln Gln Asn Pro Asp Leu His Asn
             100                 105                 110        
 Ala Val Leu Ser Lys Met Leu Gly Lys Ala Trp Lys Glu Leu Asn Ala
         115                 120                 125            
 Ala Glu Lys Arg Pro Phe Val Glu Glu Ala Glu Arg Leu Arg Val Gln
     130                 135                 140                
 His Leu Arg Asp His Pro Asn Tyr Lys Tyr Arg Pro Arg Arg Lys Lys
 145                 150                 155                 160
 Gln Ala Arg Lys Ala Arg Arg Leu Glu Pro Gly Leu Leu Leu Pro Gly
                 165                 170                 175    
 Leu Ala Pro Pro Gln Pro Pro Pro Glu Pro Phe Pro Ala Ala Ser Gly
             180                 185                 190        
 Ser Ala Arg Ala Phe Arg Glu Leu Pro Pro Leu Gly Ala Glu Phe Asp
         195                 200                 205            
 Gly Leu Gly Leu Pro Thr Pro Glu Arg Ser Pro Leu Asp Gly Leu Glu
     210                 215                 220                
 Pro Gly Glu Ala Ala Phe Phe Pro Pro Pro Ala Ala Pro Glu Asp Cys
 225                 230                 235                 240
 Ala Leu Arg Pro Phe Arg Ala Pro Tyr Ala Pro Thr Glu Leu Ser Arg
                 245                 250                 255    
 Asp Pro Gly Gly Cys Tyr Gly Ala Pro Leu Ala Glu Ala Leu Arg Thr
             260                 265                 270        
 Ala Pro Pro Ala Ala Pro Leu Ala Gly Leu Tyr Tyr Gly Thr Leu Gly
         275                 280                 285            
 Thr Pro Gly Pro Tyr Pro Gly Pro Leu Ser Pro Pro Pro Glu Ala Pro
     290                 295                 300                
 Pro Leu Glu Ser Ala Glu Pro Leu Gly Pro Ala Ala Asp Leu Trp Ala
 305                 310                 315                 320
 Asp Val Asp Leu Thr Glu Phe Asp Gln Tyr Leu Asn Cys Ser Arg Thr
                 325                 330                 335    
 Arg Pro Asp Ala Pro Gly Leu Pro Tyr His Val Ala Leu Ala Lys Leu
             340                 345                 350        
 Gly Pro Arg Ala Met Ser Cys Pro Glu Glu Ser Ser Leu Ile Ser Ala
         355                 360                 365            
 Leu Ser Asp Ala Ser Ser Ala Val Tyr Tyr Ser Ala Cys Ile Ser Gly
     370                 375                 380                





      <210> 1157
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 1157
 Met Ser Val Arg Thr Leu Pro Leu Leu Phe Leu Asn Leu Gly Gly Glu
   1               5                  10                  15    
 Met Leu Tyr Ile Leu Asp Gln Arg Leu Arg Ala Gln Asn Ile Pro Gly
              20                  25                  30        
 Asp Lys Ala Arg Lys Asp Glu Trp Thr Glu Val Asp Arg Lys Arg Val
          35                  40                  45            
 Leu Asn Asp Ile Ile Ser Thr Met Phe Asn Arg Lys Phe Met Glu Glu
      50                  55                  60                
 Leu Phe Lys Pro Gln Glu Leu Tyr Ser Lys Lys Ala Leu Arg Thr Val
  65                  70                  75                  80
 Tyr Glu Arg Leu Ala His Ala Ser Ile Met Lys Leu Asn Gln Ala Ser
                  85                  90                  95    
 Met Asp Lys Leu Tyr Asp Leu Met Thr Met Ala Phe Lys Tyr Gln Val
             100                 105                 110        
 Leu Leu Cys Pro Arg Pro Lys Asp Val Leu Leu Val Thr Phe Asn His
         115                 120                 125            
 Leu Asp Thr Ile Lys Gly Phe Ile Arg Asp Ser Pro Thr Ile Leu Gln
     130                 135                 140                
 Gln Val Asp Glu Thr Leu Arg Gln Leu Thr Glu Ile Tyr Gly Gly Leu
 145                 150                 155                 160
 Ser Ala Gly Glu Phe Gln Leu Ile Arg Gln Thr Leu Leu Ile Phe Phe
                 165                 170                 175    
 Gln Asp Leu His Ile Arg Arg Glu Cys Phe Trp Lys His Met Gln Glu
             180                 185                 190        
 Thr Val His Ser Ala Gln Cys Cys Leu Pro Gly Val Gly Asn Tyr Met
         195                 200                 205            
 Glu Asp Arg Arg Arg Arg Leu Thr Phe His Tyr Val Tyr Pro Phe Glu
     210                 215                 220                
 Asn Phe Glu Phe Cys Thr Trp Ala Lys
 225                 230            



      <210> 1158
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 1158
 Met Ser Val Arg Thr Leu Pro Leu Leu Phe Leu Asn Leu Gly Gly Glu
   1               5                  10                  15    
 Met Leu Tyr Ile Leu Asp Gln Arg Leu Arg Ala Gln Asn Ile Pro Gly
              20                  25                  30        
 Asp Lys Ala Arg Lys Asp Glu Trp Thr Glu Val Asp Arg Lys Arg Val
          35                  40                  45            
 Leu Asn Asp Ile Ile Ser Thr Met Phe Asn Arg Lys Phe Met Glu Glu
      50                  55                  60                
 Leu Phe Lys Pro Gln Glu Leu Tyr Ser Lys Lys Ala Leu Arg Thr Val
  65                  70                  75                  80
 Tyr Glu Arg Leu Ala His Ala Ser Ile Met Lys Leu Asn Gln Ala Ser
                  85                  90                  95    
 Met Asp Lys Leu Tyr Asp Leu Met Thr Met Ala Phe Lys Tyr Gln Val
             100                 105                 110        
 Leu Leu Cys Pro Arg Pro Lys Asp Val Leu Leu Val Thr Phe Asn His
         115                 120                 125            
 Leu Asp Thr Ile Lys Gly Phe Ile Arg Asp Ser Pro Thr Ile Leu Gln
     130                 135                 140                
 Gln Val Asp Glu Thr Leu Arg Gln Leu Thr Glu Ile Tyr Gly Gly Leu
 145                 150                 155                 160
 Ser Ala Gly Glu Phe Gln Leu Ile Arg Gln Thr Leu Leu Ile Phe Phe
                 165                 170                 175    
 Gln Asp Leu His Ile Arg Arg Glu Cys Phe Trp Lys His Met Gln Glu
             180                 185                 190        
 Thr Val His Ser Ala Gln Cys Cys Leu Pro Gly Val Gly Asn Tyr Met
         195                 200                 205            
 Glu Asp Arg Arg Arg Arg Leu Thr Phe His Tyr Val Tyr Pro Phe Glu
     210                 215                 220                
 Asn Phe Glu Phe Cys Thr Trp Ala Lys
 225                 230            



      <210> 1159
      <211> 649
      <212> PRT
      <213> Homo sapiens


      <400> 1159
 Met Ser Leu Ala Phe Lys Ile Phe Phe Pro Gln Thr Leu Arg Ala Leu
   1               5                  10                  15    
 Ser Arg Lys Glu Leu Cys Leu Phe Arg Lys His His Trp Arg Asp Val
              20                  25                  30        
 Arg Gln Phe Ser Gln Trp Ser Glu Thr Asp Leu Leu His Gly His Pro
          35                  40                  45            
 Leu Phe Leu Arg Arg Lys Pro Val Leu Ser Phe Gln Gly Ser His Leu
      50                  55                  60                
 Arg Ser Arg Ala Thr Tyr Leu Val Phe Leu Pro Gly Leu His Val Gly
  65                  70                  75                  80
 Leu Cys Ser Gly Pro Cys Glu Met Ala Glu Gln Arg Phe Cys Val Asp
                  85                  90                  95    
 Tyr Ala Lys Arg Gly Thr Ala Gly Cys Lys Lys Cys Lys Glu Lys Ile
             100                 105                 110        
 Val Lys Gly Val Cys Arg Ile Gly Lys Val Val Pro Asn Pro Phe Ser
         115                 120                 125            
 Glu Ser Gly Gly Asp Met Lys Glu Trp Tyr His Ile Lys Cys Met Phe
     130                 135                 140                
 Glu Lys Leu Glu Arg Ala Arg Ala Thr Thr Lys Lys Ile Glu Asp Leu
 145                 150                 155                 160
 Thr Glu Leu Glu Gly Trp Glu Glu Leu Glu Asp Asn Glu Lys Glu Gln
                 165                 170                 175    
 Ile Thr Gln His Ile Ala Asp Leu Ser Ser Lys Ala Ala Gly Thr Pro
             180                 185                 190        
 Lys Lys Lys Ala Val Val Gln Ala Lys Leu Thr Thr Thr Gly Gln Val
         195                 200                 205            
 Thr Ser Pro Val Lys Gly Ala Ser Phe Val Thr Ser Thr Asn Pro Arg
     210                 215                 220                
 Lys Phe Ser Gly Phe Ser Ala Lys Pro Asn Asn Ser Gly Glu Ala Pro
 225                 230                 235                 240
 Ser Ser Pro Thr Pro Lys Arg Ser Leu Ser Ser Ser Lys Cys Asp Pro
                 245                 250                 255    
 Arg His Lys Asp Cys Leu Leu Arg Glu Phe Arg Lys Leu Cys Ala Met
             260                 265                 270        
 Val Ala Asp Asn Pro Ser Tyr Asn Thr Lys Thr Gln Ile Ile Gln Asp
         275                 280                 285            
 Phe Leu Arg Lys Gly Ser Ala Gly Asp Gly Phe His Gly Asp Val Tyr
     290                 295                 300                
 Leu Thr Val Lys Leu Leu Leu Pro Gly Val Ile Lys Thr Val Tyr Asn
 305                 310                 315                 320
 Leu Asn Asp Lys Gln Ile Val Lys Leu Phe Ser Arg Ile Phe Asn Cys
                 325                 330                 335    
 Asn Pro Asp Asp Met Ala Arg Asp Leu Glu Gln Gly Asp Val Ser Glu
             340                 345                 350        
 Thr Ile Arg Val Phe Phe Glu Gln Ser Lys Ser Phe Pro Pro Ala Ala
         355                 360                 365            
 Lys Ser Leu Leu Thr Ile Gln Glu Val Asp Glu Phe Leu Leu Arg Leu
     370                 375                 380                
 Ser Lys Leu Thr Lys Glu Asp Glu Gln Gln Gln Ala Leu Gln Asp Ile
 385                 390                 395                 400
 Ala Ser Arg Cys Thr Ala Asn Asp Leu Lys Cys Ile Ile Arg Leu Ile
                 405                 410                 415    
 Lys His Asp Leu Lys Met Asn Ser Gly Ala Lys His Val Leu Asp Ala
             420                 425                 430        
 Leu Asp Pro Asn Ala Tyr Glu Ala Phe Lys Ala Ser Arg Asn Leu Gln
         435                 440                 445            
 Asp Val Val Glu Arg Val Leu His Asn Ala Gln Glu Val Glu Lys Glu
     450                 455                 460                
 Pro Gly Gln Arg Arg Ala Leu Ser Val Gln Ala Ser Leu Met Thr Pro
 465                 470                 475                 480
 Val Gln Pro Met Leu Ala Glu Ala Cys Lys Ser Val Glu Tyr Ala Met
                 485                 490                 495    
 Lys Lys Cys Pro Asn Gly Met Phe Ser Glu Ile Lys Tyr Asp Gly Glu
             500                 505                 510        
 Arg Val Gln Val His Lys Asn Gly Asp His Phe Ser Tyr Phe Ser Arg
         515                 520                 525            
 Ser Leu Lys Pro Val Leu Pro His Lys Val Ala His Phe Lys Asp Tyr
     530                 535                 540                
 Ile Pro Gln Ala Phe Pro Gly Gly His Ser Met Ile Leu Asp Ser Glu
 545                 550                 555                 560
 Val Leu Leu Ile Asp Asn Lys Thr Gly Lys Pro Leu Pro Phe Gly Thr
                 565                 570                 575    
 Leu Gly Val His Lys Lys Ala Ala Phe Gln Asp Ala Asn Val Cys Leu
             580                 585                 590        
 Phe Val Phe Asp Cys Ile Tyr Phe Asn Asp Val Ser Leu Met Asp Arg
         595                 600                 605            
 Pro Leu Cys Glu Arg Arg Lys Phe Leu His Asp Asn Met Val Glu Ile
     610                 615                 620                
 Pro Asn Arg Ile Met Phe Ser Glu Met Lys Arg Val Thr His Leu Ser
 625                 630                 635                 640
 Cys Pro Ser Glu Ser Phe Gly Leu Gly
                 645                



      <210> 1160
      <211> 425
      <212> PRT
      <213> Homo sapiens


      <400> 1160
 Met Asp Ser Leu Val Thr Ala Asn Thr Lys Phe Cys Phe Asp Leu Phe
   1               5                  10                  15    
 Gln Glu Ile Gly Lys Asp Asp Arg His Lys Asn Ile Phe Phe Ser Pro
              20                  25                  30        
 Leu Ser Leu Ser Ala Ala Leu Gly Met Val Arg Leu Gly Ala Arg Ser
          35                  40                  45            
 Asp Ser Ala His Gln Ile Asp Glu Val Leu His Phe Asn Glu Phe Ser
      50                  55                  60                
 Gln Asn Glu Ser Lys Glu Pro Asp Pro Cys Leu Lys Ser Asn Lys Gln
  65                  70                  75                  80
 Lys Val Leu Ala Asp Ser Ser Leu Glu Gly Gln Lys Lys Thr Thr Glu
                  85                  90                  95    
 Pro Leu Asp Gln Gln Ala Gly Ser Leu Asn Asn Glu Ser Gly Leu Val
             100                 105                 110        
 Ser Cys Tyr Phe Gly Gln Leu Leu Ser Lys Leu Asp Arg Ile Lys Thr
         115                 120                 125            
 Asp Tyr Thr Leu Ser Ile Ala Asn Arg Leu Tyr Gly Glu Gln Glu Phe
     130                 135                 140                
 Pro Ile Cys Gln Glu Tyr Leu Asp Gly Val Ile Gln Phe Tyr His Thr
 145                 150                 155                 160
 Thr Ile Glu Ser Val Asp Phe Gln Lys Asn Pro Glu Lys Ser Arg Gln
                 165                 170                 175    
 Glu Ile Asn Phe Trp Val Glu Cys Gln Ser Gln Gly Lys Ile Lys Glu
             180                 185                 190        
 Leu Phe Ser Lys Asp Ala Ile Asn Ala Glu Thr Val Leu Val Leu Val
         195                 200                 205            
 Asn Ala Val Tyr Phe Lys Ala Lys Trp Glu Thr Tyr Phe Asp His Glu
     210                 215                 220                
 Asn Thr Val Asp Ala Pro Phe Cys Leu Asn Ala Asn Glu Asn Lys Ser
 225                 230                 235                 240
 Val Lys Met Met Thr Gln Lys Gly Leu Tyr Arg Ile Gly Phe Ile Glu
                 245                 250                 255    
 Glu Val Lys Ala Gln Ile Leu Glu Met Arg Tyr Thr Lys Gly Lys Leu
             260                 265                 270        
 Ser Met Phe Val Leu Leu Pro Ser His Ser Lys Asp Asn Leu Lys Gly
         275                 280                 285            
 Leu Glu Glu Leu Glu Arg Lys Ile Thr Tyr Glu Lys Met Val Ala Trp
     290                 295                 300                
 Ser Ser Ser Glu Asn Met Ser Glu Glu Ser Val Val Leu Ser Phe Pro
 305                 310                 315                 320
 Arg Phe Thr Leu Glu Gly Ser Tyr Asp Leu Asn Ser Ile Leu Gln Asp
                 325                 330                 335    
 Met Gly Ile Thr Asp Ile Phe Asp Glu Thr Arg Ala Asp Leu Thr Gly
             340                 345                 350        
 Ile Ser Pro Ser Pro Asn Leu Tyr Leu Ser Lys Ile Ile His Lys Thr
         355                 360                 365            
 Phe Val Glu Val Asp Glu Asn Gly Thr Gln Ala Ala Ala Ala Thr Gly
     370                 375                 380                
 Ala Val Val Ser Glu Arg Ser Leu Arg Ser Trp Val Glu Phe Asn Ala
 385                 390                 395                 400
 Asn His Pro Phe Leu Phe Phe Ile Arg His Asn Lys Thr Gln Thr Ile
                 405                 410                 415    
 Leu Phe Tyr Gly Arg Val Cys Ser Pro
             420                 425



      <210> 1161
      <211> 87
      <212> PRT
      <213> Homo sapiens


      <400> 1161
 Met Ile Leu Ile Asn Phe Arg Glu Ile Cys Leu Lys Val Leu His Thr
   1               5                  10                  15    
 Pro Leu Cys Val Ser Gly Gly Cys Val Leu Leu Tyr Ile Leu Ala Leu
              20                  25                  30        
 Thr Cys Cys Tyr Thr Asn Ser Leu Leu Ile Ser His Leu Pro Pro Leu
          35                  40                  45            
 Ser Leu Pro Thr Glu Thr Gln Thr His Leu Phe Met Tyr Arg Val Leu
      50                  55                  60                
 Lys Val Arg Lys Asp Ile Lys Asn His Val Phe His Pro Thr Tyr Leu
  65                  70                  75                  80
 Val Ala Lys Glu Thr Glu Thr
                  85        



      <210> 1162
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 1162
 Met Phe Ser Tyr Leu Ile Leu Cys Pro Ser Arg Gly Ser Ser Leu Ile
   1               5                  10                  15    
 Cys Leu Ala Trp Pro Cys Val Pro Pro Val Pro Cys Ser Thr Ala Tyr
              20                  25                  30        
 Leu Val Pro Gln Val Leu Leu Ala Thr Pro Ala Val Thr Leu Asn Ser
          35                  40                  45            
 Phe Asn Ser Ala Leu Asn Ala Pro Ala Ser Glu Ala Cys Pro Ile Ser
      50                  55                  60                
 Phe Phe Leu Ala Ser Val Phe Phe Phe Leu Ser Phe Ser Leu Val Phe
  65                  70                  75                  80
 Val Glu Asp Ser Glu Glu Asn Leu Ser Tyr Gly Ser Leu Cys
                  85                  90                



      <210> 1163
      <211> 293
      <212> PRT
      <213> Homo sapiens


      <400> 1163
 Met Leu Ser Ser Asn Gly Ala Ser Lys Val Ala Asn Ser Glu Ala Met
   1               5                  10                  15    
 Ile Leu Asp Lys Asn Leu Glu Ser Val Asn Ser Pro Ile Glu Lys Ser
              20                  25                  30        
 Ser Val Asn Tyr Glu Pro Ser Asn Pro Ser Glu Lys Gly Ser Lys Lys
          35                  40                  45            
 Ile Asn Leu Ser Ser Asp Gln Asn Lys Ser Val Ser Glu Ser Asn Asn
      50                  55                  60                
 Asp Asp Val Met Leu Ile Ser Val Glu Ser Pro Asn Leu Thr Thr Pro
  65                  70                  75                  80
 Thr Thr Ser Asn Pro Thr Asp Thr Arg Lys Ile Thr Ser Gly Asn Ser
                  85                  90                  95    
 Ser Asn Ser Pro Asn Ala Glu Val Met Ala Val Gln Lys Lys Leu Asp
             100                 105                 110        
 Ser Ile Ile Asp Leu Thr Lys Glu Gly Leu Ser Asn Cys Asn Thr Glu
         115                 120                 125            
 Ser Pro Val Ser Pro Leu Glu Ser His Ser Lys Ala Ala Ser Asn Ser
     130                 135                 140                
 Lys Glu Thr Thr Pro Leu Ala Gln Asn Ala Val Gln Val Pro Glu Ser
 145                 150                 155                 160
 Phe Glu His Leu Pro Pro Leu Pro Glu Pro Pro Ala Pro Leu Pro Glu
                 165                 170                 175    
 Leu Val Asp Lys Thr Arg Asp Thr Leu Pro Pro Gln Lys Pro Glu Leu
             180                 185                 190        
 Lys Val Lys Arg Val Phe Arg Pro Asn Gly Ile Ala Leu Thr Trp Asn
         195                 200                 205            
 Ile Thr Lys Ile Asn Pro Lys Cys Ala Pro Val Glu Ser Tyr His Leu
     210                 215                 220                
 Phe Leu Cys His Glu Asn Ser Asn Asn Lys Leu Ile Trp Lys Lys Ile
 225                 230                 235                 240
 Gly Glu Ile Lys Ala Leu Pro Leu Pro Met Ala Cys Thr Leu Ser Gln
                 245                 250                 255    
 Phe Leu Ala Ser Asn Arg Tyr Tyr Phe Thr Val Gln Ser Lys Asp Ile
             260                 265                 270        
 Phe Gly Arg Tyr Gly Pro Phe Cys Asp Ile Lys Ser Ile Pro Gly Phe
         275                 280                 285            
 Ser Glu Asn Leu Thr
     290            



      <210> 1164
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 1164
 Met Pro Thr Leu Tyr Lys Lys Ala Gly Ser Ala Arg Pro Pro Phe Thr
   1               5                  10                  15    
 Met Asp Thr Leu Val Leu Val Ser Val Ile Leu Ile Thr Arg Arg Gly
              20                  25                  30        
 Pro Ala His Leu Gly Ala His Cys Gly Gly Gly Leu Val Leu Met Gln
          35                  40                  45            
 Val Leu Met Glu Leu Leu Glu Leu Ala Val Ala Phe Ala Glu Gln Glu
      50                  55                  60                
 Gln Leu Cys Leu Trp Phe Leu Arg Ile Glu Lys Pro Pro Pro Ala Ser
  65                  70                  75                  80
 Lys Val Leu Glu Asp Thr Val Gly Arg His Gln Arg Ala Phe Ser Asp
                  85                  90                  95    
 His Leu Phe Ser Arg Lys Tyr Ser Trp Glu Val Gln Asn Asn Ser Pro
             100                 105                 110        
 Leu Arg Pro Val Leu Asp Glu Met Val Val Ser Asn Thr His Ser Glu
         115                 120                 125            
 Thr Leu Gly Val
     130        



      <210> 1165
      <211> 50
      <212> PRT
      <213> Homo sapiens


      <400> 1165
 Met Ser Ser Trp Pro Arg Met Leu Ala His Cys Phe Tyr Leu Leu Lys
   1               5                  10                  15    
 Ala Leu Ser Ser Ser Tyr Leu Ile Lys Glu Met Thr Ile Met Pro Gly
              20                  25                  30        
 Thr Leu Leu Ser Thr Leu Cys Ile Leu Thr His Leu Asn Leu Pro Thr
          35                  40                  45            
 Pro Leu
      50



      <210> 1166
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 1166
 Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn Asn His Asn
   1               5                  10                  15    
 Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser Ile Arg Asp
              20                  25                  30        
 Arg Asn Gly Thr His Leu Asp Ala Gly Thr Val Glu Pro Lys Arg Glu
          35                  40                  45            
 Lys
    



      <210> 1167
      <211> 336
      <212> PRT
      <213> Homo sapiens


      <400> 1167
 Met Ala Pro Lys Leu Ile Thr Val Leu Cys Leu Gly Phe Cys Leu Asn
   1               5                  10                  15    
 Gln Lys Ile Cys Pro His Ala Gly Ala Gln Asp Lys Phe Ser Leu Ser
              20                  25                  30        
 Ala Trp Pro Ser Pro Val Val Pro Leu Gly Gly Arg Val Thr Leu Ser
          35                  40                  45            
 Cys His Ser His Leu Arg Phe Val Ile Trp Thr Ile Phe Gln Thr Thr
      50                  55                  60                
 Gly Thr Arg Ser His Glu Leu His Thr Gly Leu Ser Asn Asn Ile Thr
  65                  70                  75                  80
 Ile Ser Pro Val Thr Pro Glu His Ala Gly Thr Tyr Arg Cys Val Gly
                  85                  90                  95    
 Ile Tyr Lys His Ala Ser Lys Trp Ser Ala Glu Ser Asn Ser Leu Lys
             100                 105                 110        
 Ile Ile Val Thr Gly Leu Phe Thr Lys Pro Ser Ile Ser Ala His Pro
         115                 120                 125            
 Ser Ser Leu Val His Ala Gly Ala Arg Val Ser Leu Arg Cys His Ser
     130                 135                 140                
 Glu Leu Ala Phe Asp Glu Phe Ile Leu Tyr Lys Glu Gly His Ile Gln
 145                 150                 155                 160
 His Ser Gln Gln Leu Asp Gln Gly Met Glu Ala Gly Ile His Tyr Val
                 165                 170                 175    
 Glu Ala Val Phe Ser Met Gly Pro Val Thr Pro Ala His Ala Gly Ala
             180                 185                 190        
 Tyr Arg Cys Cys Gly Cys Phe Ser His Ser Arg Tyr Glu Trp Ser Ala
         195                 200                 205            
 Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Lys Tyr Lys Lys Pro
     210                 215                 220                
 Ser Leu Ser Thr Gln Val Asp Pro Met Met Arg Leu Gly Glu Lys Leu
 225                 230                 235                 240
 Thr Leu Phe Cys Ser Ser Glu Ile Ser Phe Asp Gln Tyr His Leu Phe
                 245                 250                 255    
 Arg His Gly Val Ala His Gly Gln Trp Leu Ser Gly Gly Gln Arg His
             260                 265                 270        
 Arg Glu Ala Phe Gln Ala Asn Phe Ser Val Gly Arg Ala Thr Pro Val
         275                 280                 285            
 Pro Gly Gly Thr Tyr Arg Cys Tyr Gly Ser Phe Asn Asp Ser Pro Tyr
     290                 295                 300                
 Lys Pro Pro Val Thr Arg Cys Asn Phe Thr Pro Gln Glu Thr Leu Arg
 305                 310                 315                 320
 Val Leu Leu Cys His Ser Gln Asn Pro Pro Leu Asn Leu Val Ser Lys
                 325                 330                 335    





      <210> 1168
      <211> 917
      <212> PRT
      <213> Homo sapiens


      <400> 1168
 Met Ala Ser Ala Ser Tyr His Ile Ser Asn Leu Leu Glu Lys Met Thr
   1               5                  10                  15    
 Ser Ser Asp Lys Asp Phe Arg Phe Met Ala Thr Asn Asp Leu Met Thr
              20                  25                  30        
 Glu Leu Gln Lys Asp Ser Ile Lys Leu Asp Asp Asp Ser Glu Arg Lys
          35                  40                  45            
 Val Val Lys Met Ile Leu Lys Leu Leu Glu Asp Lys Asn Gly Glu Val
      50                  55                  60                
 Gln Asn Leu Ala Val Lys Cys Leu Gly Pro Leu Val Ser Lys Val Lys
  65                  70                  75                  80
 Glu Tyr Gln Val Glu Thr Ile Val Asp Thr Leu Cys Thr Asn Met Leu
                  85                  90                  95    
 Ser Asp Lys Glu Gln Leu Arg Asp Ile Ser Ser Ile Gly Leu Lys Thr
             100                 105                 110        
 Val Ile Gly Glu Leu Pro Pro Ala Ser Ser Gly Ser Ala Leu Ala Ala
         115                 120                 125            
 Asn Val Cys Lys Lys Ile Thr Gly Arg Leu Thr Ser Ala Ile Ala Lys
     130                 135                 140                
 Gln Glu Asp Val Ser Val Gln Leu Glu Ala Leu Asp Ile Met Ala Asp
 145                 150                 155                 160
 Met Leu Ser Arg Gln Gly Gly Leu Leu Val Asn Phe His Pro Ser Ile
                 165                 170                 175    
 Leu Thr Cys Leu Leu Pro Gln Leu Thr Ser Pro Arg Leu Ala Val Arg
             180                 185                 190        
 Lys Arg Thr Ile Ile Ala Leu Gly His Leu Val Met Ser Cys Gly Asn
         195                 200                 205            
 Ile Val Phe Val Asp Leu Ile Glu His Leu Leu Ser Glu Leu Ser Lys
     210                 215                 220                
 Asn Asp Ser Met Ser Thr Thr Arg Thr Tyr Ile Gln Cys Ile Ala Ala
 225                 230                 235                 240
 Ile Ser Arg Gln Ala Gly His Arg Ile Gly Glu Tyr Leu Glu Lys Ile
                 245                 250                 255    
 Ile Pro Leu Val Val Lys Phe Cys Asn Val Asp Asp Asp Glu Leu Arg
             260                 265                 270        
 Glu Tyr Cys Ile Gln Ala Phe Glu Ser Phe Val Arg Arg Cys Pro Lys
         275                 280                 285            
 Glu Val Tyr Pro His Val Ser Thr Ile Ile Asn Ile Cys Leu Lys Tyr
     290                 295                 300                
 Leu Thr Tyr Asp Pro Asn Tyr Asn Tyr Asp Asp Glu Asp Glu Asp Glu
 305                 310                 315                 320
 Asn Ala Met Asp Ala Asp Gly Gly Asp Asp Asp Asp Gln Gly Ser Asp
                 325                 330                 335    
 Asp Glu Tyr Ser Asp Asp Asn Asp Met Ser Trp Lys Val Arg Arg Ala
             340                 345                 350        
 Ala Ala Lys Cys Leu Asp Ala Val Val Ser Thr Arg His Glu Met Leu
         355                 360                 365            
 Pro Glu Phe Tyr Lys Thr Val Ser Pro Ala Leu Ile Ser Arg Phe Lys
     370                 375                 380                
 Glu Arg Glu Glu Asn Val Lys Ala Asp Val Phe His Ala Tyr Leu Ser
 385                 390                 395                 400
 Leu Leu Lys Gln Thr Arg Pro Val Gln Ser Trp Leu Cys Asp Pro Asp
                 405                 410                 415    
 Ala Met Glu Gln Gly Glu Thr Pro Leu Thr Met Leu Gln Ser Gln Val
             420                 425                 430        
 Pro Asn Ile Val Lys Ala Leu His Lys Gln Met Lys Glu Lys Ser Val
         435                 440                 445            
 Lys Thr Arg Gln Cys Cys Phe Asn Met Leu Thr Glu Leu Val Asn Val
     450                 455                 460                
 Leu Pro Gly Ala Leu Thr Gln His Ile Pro Val Leu Val Pro Gly Ile
 465                 470                 475                 480
 Ile Phe Ser Leu Asn Asp Lys Ser Ser Ser Ser Asn Leu Lys Ile Asp
                 485                 490                 495    
 Ala Leu Ser Cys Leu Tyr Val Ile Leu Cys Asn His Ser Pro Gln Val
             500                 505                 510        
 Phe His Pro His Val Gln Ala Leu Val Pro Pro Val Val Ala Cys Val
         515                 520                 525            
 Gly Asp Pro Phe Tyr Lys Ile Thr Ser Glu Ala Leu Leu Val Thr Gln
     530                 535                 540                
 Gln Leu Val Lys Val Ile Arg Pro Leu Asp Gln Pro Ser Ser Phe Asp
 545                 550                 555                 560
 Ala Thr Pro Tyr Ile Lys Asp Leu Phe Thr Cys Thr Ile Lys Arg Leu
                 565                 570                 575    
 Lys Ala Ala Asp Ile Asp Gln Glu Val Lys Glu Arg Ala Ile Ser Cys
             580                 585                 590        
 Met Gly Gln Ile Ile Cys Asn Leu Gly Asp Asn Leu Gly Ser Asp Leu
         595                 600                 605            
 Pro Asn Thr Leu Gln Ile Phe Leu Glu Arg Leu Lys Asn Glu Ile Thr
     610                 615                 620                
 Arg Leu Thr Thr Val Lys Ala Leu Thr Leu Ile Ala Gly Ser Pro Leu
 625                 630                 635                 640
 Lys Ile Asp Leu Arg Pro Val Leu Gly Glu Gly Val Pro Ile Leu Ala
                 645                 650                 655    
 Ser Phe Leu Arg Lys Asn Gln Arg Ala Leu Lys Leu Gly Thr Leu Ser
             660                 665                 670        
 Ala Leu Asp Ile Leu Ile Lys Asn Tyr Ser Asp Ser Leu Thr Ala Ala
         675                 680                 685            
 Met Ile Asp Ala Val Leu Asp Glu Leu Pro Pro Leu Ile Ser Glu Ser
     690                 695                 700                
 Asp Met His Val Ser Gln Met Ala Ile Ser Phe Leu Thr Thr Leu Ala
 705                 710                 715                 720
 Lys Val Tyr Pro Ser Ser Leu Ser Lys Ile Ser Gly Ser Ile Leu Asn
                 725                 730                 735    
 Glu Leu Ile Gly Leu Val Arg Ser Pro Leu Leu Gln Gly Gly Ala Leu
             740                 745                 750        
 Ser Ala Met Leu Asp Phe Phe Gln Ala Leu Val Val Thr Gly Thr Asn
         755                 760                 765            
 Asn Leu Gly Tyr Met Asp Leu Leu Arg Met Leu Thr Gly Pro Val Tyr
     770                 775                 780                
 Ser Gln Ser Thr Ala Leu Thr His Lys Gln Ser Tyr Tyr Ser Ile Ala
 785                 790                 795                 800
 Lys Cys Val Ala Ala Leu Thr Arg Ala Cys Pro Lys Glu Gly Pro Ala
                 805                 810                 815    
 Val Val Gly Gln Phe Ile Gln Asp Val Lys Asn Ser Arg Ser Thr Asp
             820                 825                 830        
 Ser Ile Arg Leu Leu Ala Leu Leu Ser Leu Gly Glu Val Gly His His
         835                 840                 845            
 Ile Asp Leu Ser Gly Gln Leu Glu Leu Lys Ser Val Ile Leu Glu Ala
     850                 855                 860                
 Phe Ser Ser Pro Ser Glu Glu Val Lys Ser Ala Ala Ser Tyr Ala Leu
 865                 870                 875                 880
 Gly Ser Ile Ser Val Gly Asn Leu Pro Glu Tyr Leu Pro Phe Val Leu
                 885                 890                 895    
 Gln Glu Ile Thr Ser Gln Pro Lys Arg Gln Tyr Leu Phe Thr Ser Phe
             900                 905                 910        
 Leu Glu Gly Asn Tyr
         915        



      <210> 1169
      <211> 231
      <212> PRT
      <213> Homo sapiens


      <400> 1169
 Met Gln Asp Glu Glu Arg Tyr Met Thr Leu Asn Val Gln Ser Lys Lys
   1               5                  10                  15    
 Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr Ser Val
              20                  25                  30        
 Thr Leu His Trp Tyr Lys Ile Leu Leu Gly Ile Ser Gly Thr Val Asn
          35                  40                  45            
 Gly Ile Leu Thr Leu Thr Leu Ile Ser Leu Ile Leu Leu Val Ser Gln
      50                  55                  60                
 Gly Val Leu Leu Lys Cys Gln Lys Gly Ser Cys Ser Asn Ala Thr Gln
  65                  70                  75                  80
 Tyr Glu Asp Thr Gly Asp Leu Lys Val Asn Asn Gly Thr Arg Arg Asn
                  85                  90                  95    
 Ile Ser Asn Lys Asp Leu Cys Ala Ser Arg Ser Ala Asp Gln Thr Val
             100                 105                 110        
 Leu Cys Gln Ser Glu Trp Leu Lys Tyr Gln Gly Lys Cys Tyr Trp Phe
         115                 120                 125            
 Ser Asn Glu Met Lys Ser Trp Ser Asp Ser Tyr Val Tyr Cys Leu Glu
     130                 135                 140                
 Arg Lys Ser His Leu Leu Ile Ile His Asp Gln Leu Glu Met Ala Phe
 145                 150                 155                 160
 Ile Gln Lys Asn Leu Arg Gln Leu Asn Tyr Val Trp Ile Gly Leu Asn
                 165                 170                 175    
 Phe Thr Ser Leu Lys Met Thr Trp Thr Trp Val Asp Gly Ser Pro Ile
             180                 185                 190        
 Asp Ser Lys Ile Phe Phe Ile Lys Gly Pro Ala Lys Glu Asn Ser Cys
         195                 200                 205            
 Ala Ala Ile Lys Glu Ser Lys Ile Phe Ser Glu Thr Cys Ser Ser Val
     210                 215                 220                
 Phe Lys Trp Ile Cys Gln Tyr
 225                 230    



      <210> 1170
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 1170
 Met Cys Cys Glu Leu Leu Ala Val Val Ile Ala Thr Leu Ile Ile Lys
   1               5                  10                  15    
 Ile Gly Leu Val Val Leu Leu Tyr Phe Ile Lys Leu Leu Ile His Ile
              20                  25                  30        
 Glu Phe Ile Lys Arg His Ser Ile Leu Lys Cys Glu Ser Ile Phe Asn
          35                  40                  45            
 Leu Asn Val Gly Ile Arg Met Tyr Pro Gly Gln Val Asn Phe Cys Glu
      50                  55                  60                
 Thr Leu Gln Met Leu Asp Gly Phe Gly Arg Ile Phe Gln Thr Lys Trp
  65                  70                  75                  80
 Thr Asn Leu Tyr Ser Tyr Ile Asn Ser Asn Phe Leu Arg Ala Thr Asp
                  85                  90                  95    
 Lys Leu Phe Asp Ser
             100    



      <210> 1171
      <211> 577
      <212> PRT
      <213> Homo sapiens


      <400> 1171
 Met Thr Glu Leu Ala Gly Ala Ser Ser Ser Cys Cys His Arg Pro Ala
   1               5                  10                  15    
 Gly Arg Gly Ala Met Gln Ser Val Leu His His Phe Gln Arg Leu Arg
              20                  25                  30        
 Gly Arg Glu Gly Gly Ser His Phe Ile Asn Thr Ser Ser Pro Arg Gly
          35                  40                  45            
 Glu Ala Lys Met Ser Ile Thr Ser Asp Glu Val Asn Phe Leu Val Tyr
      50                  55                  60                
 Arg Tyr Leu Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly
  65                  70                  75                  80
 Ile Glu Ser His Ile Ser Gln Ser Asn Ile Asn Gly Thr Leu Val Pro
                  85                  90                  95    
 Pro Ala Ala Leu Ile Ser Ile Leu Gln Lys Gly Leu Gln Tyr Val Glu
             100                 105                 110        
 Ala Glu Ile Ser Ile Asn Glu Asp Gly Thr Val Phe Asp Gly Arg Pro
         115                 120                 125            
 Ile Glu Ser Leu Ser Leu Ile Asp Ala Val Met Pro Asp Val Val Gln
     130                 135                 140                
 Thr Arg Gln Gln Ala Phe Arg Glu Lys Leu Ala Gln Gln Gln Ala Ser
 145                 150                 155                 160
 Ala Ala Ala Ala Ala Ala Ala Ala Thr Ala Ala Ala Thr Ala Ala Thr
                 165                 170                 175    
 Thr Thr Ser Ala Gly Val Ser His Gln Asn Pro Ser Lys Asn Arg Glu
             180                 185                 190        
 Ala Thr Val Asn Gly Glu Glu Asn Arg Ala His Ser Val Asn Asn His
         195                 200                 205            
 Ala Lys Pro Met Glu Ile Asp Gly Glu Val Glu Ile Pro Ser Ser Lys
     210                 215                 220                
 Ala Thr Val Leu Arg Gly His Glu Ser Glu Val Phe Ile Cys Ala Trp
 225                 230                 235                 240
 Asn Pro Val Ser Asp Leu Leu Ala Ser Gly Ser Gly Asp Ser Thr Ala
                 245                 250                 255    
 Arg Ile Trp Asn Leu Asn Glu Asn Ser Asn Gly Gly Ser Thr Gln Leu
             260                 265                 270        
 Val Leu Arg His Cys Ile Arg Glu Gly Gly His Asp Val Pro Ser Asn
         275                 280                 285            
 Lys Asp Val Thr Ser Leu Asp Trp Asn Thr Asn Gly Thr Leu Leu Ala
     290                 295                 300                
 Thr Gly Ser Tyr Asp Gly Phe Ala Arg Ile Trp Thr Glu Asp Gly Asn
 305                 310                 315                 320
 Leu Ala Ser Thr Leu Gly Gln His Lys Gly Pro Ile Phe Ala Leu Lys
                 325                 330                 335    
 Trp Asn Arg Lys Gly Asn Tyr Ile Leu Ser Ala Gly Val Asp Lys Thr
             340                 345                 350        
 Thr Ile Ile Trp Asp Ala His Thr Gly Glu Ala Lys Gln Gln Phe Pro
         355                 360                 365            
 Phe His Ser Ala Pro Ala Leu Asp Val Asp Trp Gln Asn Asn Thr Thr
     370                 375                 380                
 Phe Ala Ser Cys Ser Thr Asp Met Cys Ile His Val Cys Arg Leu Gly
 385                 390                 395                 400
 Cys Asp Arg Pro Val Lys Thr Phe Gln Gly His Thr Asn Glu Val Asn
                 405                 410                 415    
 Ala Ile Lys Trp Asp Pro Ser Gly Met Leu Leu Ala Ser Cys Ser Asp
             420                 425                 430        
 Asp Met Thr Leu Lys Ile Trp Ser Met Lys Gln Glu Val Cys Ile His
         435                 440                 445            
 Asp Leu Gln Ala His Asn Lys Glu Ile Tyr Thr Ile Lys Trp Ser Pro
     450                 455                 460                
 Thr Gly Pro Ala Thr Ser Asn Pro Asn Ser Asn Ile Met Leu Ala Ser
 465                 470                 475                 480
 Ala Ser Phe Asp Ser Thr Val Arg Leu Trp Asp Ile Glu Arg Gly Val
                 485                 490                 495    
 Cys Thr His Thr Leu Thr Lys His Gln Glu Pro Val Tyr Ser Val Ala
             500                 505                 510        
 Phe Ser Pro Asp Gly Lys Tyr Leu Ala Ser Gly Ser Phe Asp Lys Cys
         515                 520                 525            
 Val His Ile Trp Asn Thr Gln Ser Gly Asn Leu Val His Ser Tyr Arg
     530                 535                 540                
 Gly Thr Gly Gly Ile Phe Glu Val Cys Trp Asn Ala Arg Gly Asp Lys
 545                 550                 555                 560
 Val Gly Ala Ser Ala Ser Asp Gly Ser Val Cys Val Leu Asp Leu Arg
                 565                 570                 575    
 Lys
    



      <210> 1172
      <211> 777
      <212> PRT
      <213> Homo sapiens


      <400> 1172
 Met Ile Pro Lys Leu Leu Ser Leu Leu Cys Phe Arg Leu Cys Val Gly
   1               5                  10                  15    
 Gln Gly Asp Thr Arg Gly Asp Gly Ser Leu Pro Lys Pro Ser Leu Ser
              20                  25                  30        
 Ala Trp Pro Ser Ser Val Val Pro Ala Asn Ser Asn Val Thr Leu Arg
          35                  40                  45            
 Cys Trp Thr Pro Ala Arg Gly Val Ser Phe Val Leu Arg Lys Gly Gly
      50                  55                  60                
 Ile Ile Leu Glu Ser Pro Lys Pro Leu Asp Ser Thr Glu Gly Ala Ala
  65                  70                  75                  80
 Glu Phe His Leu Asn Asn Leu Lys Val Arg Asn Ala Gly Glu Tyr Thr
                  85                  90                  95    
 Cys Glu Tyr Tyr Arg Lys Ala Ser Pro His Ile Leu Ser Gln Arg Ser
             100                 105                 110        
 Asp Val Leu Leu Leu Leu Val Thr Gly His Leu Ser Lys Pro Phe Leu
         115                 120                 125            
 Arg Thr Tyr Gln Arg Gly Thr Val Thr Ala Gly Gly Arg Val Thr Leu
     130                 135                 140                
 Gln Cys Gln Lys Arg Asp Gln Leu Phe Val Pro Ile Met Phe Ala Leu
 145                 150                 155                 160
 Leu Lys Ala Gly Thr Pro Ser Pro Ile Gln Leu Gln Ser Pro Ala Gly
                 165                 170                 175    
 Lys Glu Ile Asp Phe Ser Leu Val Asp Val Thr Ala Gly Asp Ala Gly
             180                 185                 190        
 Asn Tyr Ser Cys Met Tyr Tyr Gln Thr Lys Ser Pro Phe Trp Ala Ser
         195                 200                 205            
 Glu Pro Ser Asp Gln Leu Glu Ile Leu Val Thr Ala Glu Thr Cys Gly
     210                 215                 220                
 Ser Gln Gly Ser Ser Val Arg Thr Cys Ala Val Gln His Gly Ser Arg
 225                 230                 235                 240
 Trp Pro Gln Pro Leu Gly Asp Lys Leu Phe Arg Trp Trp Leu Leu Pro
                 245                 250                 255    
 Leu Ser Arg Phe Leu Met Arg Val Leu Asp Ser Tyr Gly Asp Asp Tyr
             260                 265                 270        
 Arg Ala Ser Gln Phe Thr Ile Val Leu Glu Asp Glu Gly Ser Gln Gly
         275                 280                 285            
 Thr Asp Ala Pro Thr Pro Gly Asn Ala Glu Asn Glu Leu Arg Glu Arg
     290                 295                 300                
 Asp Thr Val Pro Ala Gln Lys Asp Ser Cys Thr Pro Arg Thr Arg Gln
 305                 310                 315                 320
 Pro Ser Pro Arg Tyr Ser Leu Gly Lys Ala Trp Lys Glu Ala Thr Ala
                 325                 330                 335    
 Gln Gly Thr Ala Gly Ser Lys Asp Arg Ser Ala Glu Leu Ser Gln Gln
             340                 345                 350        
 Asp Cys Gly Ala Ala Gly Lys Asp Ser Pro Ala Gln Gly Pro Ser Phe
         355                 360                 365            
 Ser Ala Thr Gln Leu Ala Ala Pro Gly Arg Pro Gly Ala Asp Leu Ser
     370                 375                 380                
 Glu Ala Leu Val His Ala Gly Pro Leu Cys Pro Pro Pro Ala Leu Asp
 385                 390                 395                 400
 Phe Ser Asp Gly Ala Arg Pro Ser Leu Ser Ser Val Leu Asn Glu Leu
                 405                 410                 415    
 Pro Ser Ala Ala Thr Leu Arg Tyr Arg Asp Pro Gly Val Leu Pro Trp
             420                 425                 430        
 Gly Ala Leu Glu Glu Glu Glu Glu Asp Gly Gly Arg Ser Arg Lys Ala
         435                 440                 445            
 Phe Thr Glu Val Thr Gln Thr Glu Leu Gln Asp Pro His Pro Ser Arg
     450                 455                 460                
 Glu Leu Pro Trp Pro Met Gln Ala Arg Arg Ala His Arg Gln Arg Asn
 465                 470                 475                 480
 Ala Ser Arg Asp Gln Val Val Tyr Gly Ser Gly Thr Lys Thr Asp Arg
                 485                 490                 495    
 Trp Ala Arg Leu Leu Arg Arg Ser Lys Glu Lys Thr Lys Glu Gly Leu
             500                 505                 510        
 Arg Ser Leu Gln Pro Trp Ala Trp Thr Leu Lys Arg Ile Gly Gly Ala
         515                 520                 525            
 Val Pro Ile Gln Asn Val Thr Pro His Gln Ala Ser Pro Gln Arg Asn
     530                 535                 540                
 Glu Val Glu Ala Ser Arg Trp Thr Glu Ala Ala Leu Ala Ala Arg Leu
 545                 550                 555                 560
 Ala Gly Ile Gly Ser Trp Ser Ser Pro Ser Pro Gly Gln Cys Gln Pro
                 565                 570                 575    
 Ala Pro Leu Leu Arg Arg Ala Trp Pro Ala Pro Leu Phe Gly Leu Leu
             580                 585                 590        
 Phe Leu Leu Ser Ser His Leu Phe Pro Leu Glu Ala Val Arg Glu Asp
         595                 600                 605            
 Ala Phe Tyr Ala Arg Pro Leu Pro Ala Arg Leu Phe Tyr Met Ile Pro
     610                 615                 620                
 Val Phe Phe Ala Phe Arg Met Arg Phe Tyr Val Ala Trp Ile Ala Ala
 625                 630                 635                 640
 Glu Cys Ala Ala Leu Pro Pro Ala Leu Gly Pro Thr Pro Trp Pro Pro
                 645                 650                 655    
 Lys Pro Gly Pro Glu Ala Ala Pro Pro Ser Asn Ala His Pro Pro Ala
             660                 665                 670        
 Ala Ser Leu Thr Ala Arg Gly Pro Leu Pro Gly Gln Asp Pro Phe Leu
         675                 680                 685            
 Ser Ile Arg Gly Trp Asp Thr Ser Arg Arg Arg Glu Gly Ala Trp Leu
     690                 695                 700                
 Ser Cys Met Ser Val Pro His Pro His Pro Pro Pro Pro Ser Pro Glu
 705                 710                 715                 720
 Lys Ala Ala Ser Leu Glu Tyr Asp Tyr Glu Thr Ile Arg Asn Ile Asp
                 725                 730                 735    
 Cys Tyr Ser Thr Asp Phe Cys Val Arg Val Arg Asp Gly Met Arg Tyr
             740                 745                 750        
 Trp Asn Met Thr Val Gln Trp Trp Leu Ala Gln Tyr Ile Tyr Lys Ser
         755                 760                 765            
 Ala Pro Ala Arg Ser Tyr Val Leu Arg
     770                 775        



      <210> 1173
      <211> 777
      <212> PRT
      <213> Homo sapiens


      <400> 1173
 Met Ile Pro Lys Leu Leu Ser Leu Leu Cys Phe Arg Leu Cys Val Gly
   1               5                  10                  15    
 Gln Gly Asp Thr Arg Gly Asp Gly Ser Leu Pro Lys Pro Ser Leu Ser
              20                  25                  30        
 Ala Trp Pro Ser Ser Val Val Pro Ala Asn Ser Asn Val Thr Leu Arg
          35                  40                  45            
 Cys Trp Thr Pro Ala Arg Gly Val Ser Phe Val Leu Arg Lys Gly Gly
      50                  55                  60                
 Ile Ile Leu Glu Ser Pro Lys Pro Leu Asp Ser Thr Glu Gly Ala Ala
  65                  70                  75                  80
 Glu Phe His Leu Asn Asn Leu Lys Val Arg Asn Ala Gly Glu Tyr Thr
                  85                  90                  95    
 Cys Glu Tyr Tyr Arg Lys Ala Ser Pro His Ile Leu Ser Gln Arg Ser
             100                 105                 110        
 Asp Val Leu Leu Leu Leu Val Thr Gly His Leu Ser Lys Pro Phe Leu
         115                 120                 125            
 Arg Thr Tyr Gln Arg Gly Thr Val Thr Ala Gly Gly Arg Val Thr Leu
     130                 135                 140                
 Gln Cys Gln Lys Arg Asp Gln Leu Phe Val Pro Ile Met Phe Ala Leu
 145                 150                 155                 160
 Leu Lys Ala Gly Thr Pro Ser Pro Ile Gln Leu Gln Ser Pro Ala Gly
                 165                 170                 175    
 Lys Glu Ile Asp Phe Ser Leu Val Asp Val Thr Ala Gly Asp Ala Gly
             180                 185                 190        
 Asn Tyr Ser Cys Met Tyr Tyr Gln Thr Lys Ser Pro Phe Trp Ala Ser
         195                 200                 205            
 Glu Pro Ser Asp Gln Leu Glu Ile Leu Val Thr Ala Glu Thr Cys Gly
     210                 215                 220                
 Ser Gln Gly Ser Ser Val Arg Thr Cys Ala Val Gln His Gly Ser Arg
 225                 230                 235                 240
 Trp Pro Gln Pro Leu Gly Asp Lys Leu Phe Arg Trp Trp Leu Leu Pro
                 245                 250                 255    
 Leu Ser Arg Phe Leu Met Arg Val Leu Asp Ser Tyr Gly Asp Asp Tyr
             260                 265                 270        
 Arg Ala Ser Gln Phe Thr Ile Val Leu Glu Asp Glu Gly Ser Gln Gly
         275                 280                 285            
 Thr Asp Ala Pro Thr Pro Gly Asn Ala Glu Asn Glu Leu Arg Glu Arg
     290                 295                 300                
 Asp Thr Val Pro Ala Gln Lys Asp Ser Cys Thr Pro Arg Thr Arg Gln
 305                 310                 315                 320
 Pro Ser Pro Arg Tyr Ser Leu Gly Lys Ala Trp Lys Glu Ala Thr Ala
                 325                 330                 335    
 Gln Gly Thr Ala Gly Ser Lys Asp Arg Ser Ala Glu Leu Ser Gln Gln
             340                 345                 350        
 Asp Cys Gly Ala Ala Gly Lys Asp Ser Pro Ala Gln Gly Pro Ser Phe
         355                 360                 365            
 Ser Ala Thr Gln Leu Ala Ala Pro Gly Arg Pro Gly Ala Asp Leu Ser
     370                 375                 380                
 Glu Ala Leu Val His Ala Gly Pro Leu Cys Pro Pro Pro Ala Leu Asp
 385                 390                 395                 400
 Phe Ser Asp Gly Ala Arg Pro Ser Leu Ser Ser Val Leu Asn Glu Leu
                 405                 410                 415    
 Pro Ser Ala Ala Thr Leu Arg Tyr Arg Asp Pro Gly Val Leu Pro Trp
             420                 425                 430        
 Gly Ala Leu Glu Glu Glu Glu Glu Asp Gly Gly Arg Ser Arg Lys Ala
         435                 440                 445            
 Phe Thr Glu Val Thr Gln Thr Glu Leu Gln Asp Pro His Pro Ser Arg
     450                 455                 460                
 Glu Leu Pro Trp Pro Met Gln Ala Arg Arg Ala His Arg Gln Arg Asn
 465                 470                 475                 480
 Ala Ser Arg Asp Gln Val Val Tyr Gly Ser Gly Thr Lys Thr Asp Arg
                 485                 490                 495    
 Trp Ala Arg Leu Leu Arg Arg Ser Lys Glu Lys Thr Lys Glu Gly Leu
             500                 505                 510        
 Arg Ser Leu Gln Pro Trp Ala Trp Thr Leu Lys Arg Ile Gly Gly Ala
         515                 520                 525            
 Val Pro Ile Gln Asn Val Thr Pro His Gln Ala Ser Pro Gln Arg Asn
     530                 535                 540                
 Glu Val Glu Ala Ser Arg Trp Thr Glu Ala Ala Leu Ala Ala Arg Leu
 545                 550                 555                 560
 Ala Gly Ile Gly Ser Trp Ser Ser Pro Ser Pro Gly Gln Cys Gln Pro
                 565                 570                 575    
 Ala Pro Leu Leu Arg Arg Ala Trp Pro Ala Pro Leu Phe Gly Leu Leu
             580                 585                 590        
 Phe Leu Leu Ser Ser His Leu Phe Pro Leu Glu Ala Val Arg Glu Asp
         595                 600                 605            
 Ala Phe Tyr Ala Arg Pro Leu Pro Ala Arg Leu Phe Tyr Met Ile Pro
     610                 615                 620                
 Val Phe Phe Ala Phe Arg Met Arg Phe Tyr Val Ala Trp Ile Ala Ala
 625                 630                 635                 640
 Glu Cys Ala Ala Leu Pro Pro Ala Leu Gly Pro Thr Pro Trp Pro Pro
                 645                 650                 655    
 Lys Pro Gly Pro Glu Ala Ala Pro Pro Ser Asn Ala His Pro Pro Ala
             660                 665                 670        
 Ala Ser Leu Thr Ala Arg Gly Pro Leu Pro Gly Gln Asp Pro Phe Leu
         675                 680                 685            
 Ser Ile Arg Gly Trp Asp Thr Ser Arg Arg Arg Glu Gly Ala Trp Leu
     690                 695                 700                
 Ser Cys Met Ser Val Pro His Pro His Pro Pro Pro Pro Ser Pro Glu
 705                 710                 715                 720
 Lys Ala Ala Ser Leu Glu Tyr Asp Tyr Glu Thr Ile Arg Asn Ile Asp
                 725                 730                 735    
 Cys Tyr Ser Thr Asp Phe Cys Val Arg Val Arg Asp Gly Met Arg Tyr
             740                 745                 750        
 Trp Asn Met Thr Val Gln Trp Trp Leu Ala Gln Tyr Ile Tyr Lys Ser
         755                 760                 765            
 Ala Pro Ala Arg Ser Tyr Val Leu Arg
     770                 775        



      <210> 1174
      <211> 402
      <212> PRT
      <213> Homo sapiens


      <400> 1174
 Met Ser Pro Glu Glu Trp Thr Tyr Leu Val Val Leu Leu Ile Ser Ile
   1               5                  10                  15    
 Pro Ile Gly Phe Leu Phe Lys Lys Ala Gly Pro Gly Leu Lys Arg Trp
              20                  25                  30        
 Gly Ala Ala Ala Val Gly Leu Gly Leu Thr Leu Phe Thr Cys Gly Pro
          35                  40                  45            
 His Thr Leu His Ser Leu Val Thr Ile Leu Gly Thr Trp Ala Leu Ile
      50                  55                  60                
 Gln Ala Gln Pro Cys Pro Cys His Ala Leu Ala Leu Ala Trp Thr Phe
  65                  70                  75                  80
 Ser Tyr Leu Leu Phe Phe Arg Ala Leu Ser Leu Leu Gly Leu Pro Thr
                  85                  90                  95    
 Pro Thr Pro Phe Thr Asn Ala Val Gln Leu Leu Leu Thr Leu Lys Leu
             100                 105                 110        
 Val Ser Leu Ala Ser Glu Val Gln Asp Leu His Leu Ala Gln Arg Lys
         115                 120                 125            
 Glu Met Ala Ser Gly Phe Ser Lys Gly Pro Thr Leu Gly Leu Leu Pro
     130                 135                 140                
 Asp Val Pro Ser Leu Met Glu Thr Leu Ser Tyr Ser Tyr Cys Tyr Val
 145                 150                 155                 160
 Gly Ile Met Thr Gly Pro Phe Phe Arg Tyr Arg Thr Tyr Leu Asp Trp
                 165                 170                 175    
 Leu Glu Gln Pro Phe Pro Gly Ala Val Pro Ser Leu Arg Pro Leu Leu
             180                 185                 190        
 Arg Arg Ala Trp Pro Ala Pro Leu Phe Gly Leu Leu Phe Leu Leu Ser
         195                 200                 205            
 Ser His Leu Phe Pro Leu Glu Ala Val Arg Glu Asp Ala Phe Tyr Ala
     210                 215                 220                
 Arg Pro Leu Pro Ala Arg Leu Phe Tyr Met Ile Pro Val Phe Phe Ala
 225                 230                 235                 240
 Phe Arg Met Arg Phe Tyr Val Ala Trp Ile Ala Ala Glu Cys Gly Cys
                 245                 250                 255    
 Ile Ala Ala Gly Phe Gly Ala Tyr Pro Val Ala Ala Lys Ala Arg Ala
             260                 265                 270        
 Gly Gly Gly Pro Thr Leu Gln Cys Pro Pro Pro Ser Ser Pro Glu Lys
         275                 280                 285            
 Ala Ala Ser Leu Glu Tyr Asp Tyr Glu Thr Ile Arg Asn Ile Asp Cys
     290                 295                 300                
 Tyr Ser Thr Asp Phe Cys Val Arg Val Arg Asp Gly Met Arg Tyr Trp
 305                 310                 315                 320
 Asn Met Thr Val Gln Trp Trp Leu Ala Gln Tyr Ile Tyr Lys Ser Ala
                 325                 330                 335    
 Pro Ala Arg Ser Tyr Val Leu Arg Ser Ala Trp Thr Met Leu Leu Arg
             340                 345                 350        
 Arg Leu Leu Ala Arg Pro Pro Pro Gly Leu Leu Pro Glu Leu Pro Asp
         355                 360                 365            
 His Pro Ala Val Pro Gly Cys Arg Gly Pro Ala Gly Val Ser Pro Ala
     370                 375                 380                
 Gly Ala Ala Glu Pro Arg Gly Pro Glu Gly Pro Gly Thr Gly Cys Thr
 385                 390                 395                 400
 Gly Ser
        



      <210> 1175
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 1175
 Met Ser Ser Leu Ser Gly Lys Val Gln Thr Val Leu Gly Leu Val Glu
   1               5                  10                  15    
 Pro Ser Lys Leu Gly Arg Thr Leu Thr His Glu His Leu Ala Met Thr
              20                  25                  30        
 Phe Asp Cys Cys Tyr Cys Pro Pro Pro Pro Cys Gln Glu Ala Ile Ser
          35                  40                  45            
 Lys Glu Pro Ile Val Met Lys Asn Leu Tyr Trp Ile Gln Lys Asn Ala
      50                  55                  60                
 Tyr Ser His Lys Glu Asn Leu Gln Leu Asn Gln Glu Thr Glu Ala Ile
  65                  70                  75                  80
 Lys Glu Glu Leu Leu Tyr Phe Lys Ala Asn Gly Gly Gly Ala Leu Val
                  85                  90                  95    
 Glu Asn Thr Thr Thr Gly Ile Ser Arg Asp Thr Gln Thr Leu Lys Arg
             100                 105                 110        
 Leu Ala Glu Glu Thr Gly Val His Ile Ile Ser Gly Ala Gly Phe Tyr
         115                 120                 125            
 Val Asp Ala Thr His Ser Ser Glu Thr Arg Ala Met Ser Val Glu Gln
     130                 135                 140                
 Leu Thr Asp Val Leu Met Asn Glu Ile Leu His Gly Ala Asp Gly Thr
 145                 150                 155                 160
 Ser Ile Lys Cys Gly Ile Ile Gly Glu Ile Gly Cys Ser Trp Pro Leu
                 165                 170                 175    
 Thr Glu Ser Glu Arg Lys Val Leu Gln Ala Thr Ala His Ala Gln Ala
             180                 185                 190        
 Gln Leu Gly Cys Pro Val Ile Ile His Pro Gly Arg Ser Ser Arg Ala
         195                 200                 205            
 Pro Phe Gln Ile Ile Arg Ile Leu Gln Glu Ala Gly Ala Asp Ile Ser
     210                 215                 220                
 Lys Thr Val Met Ser His Leu Asp Arg
 225                 230            



      <210> 1176
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 1176
 Ser Val Tyr Ser Ala Ser Ser Cys Lys Cys Cys Asn Tyr Arg Lys Thr
   1               5                  10                  15    
 Glu Gln Ile Pro Asp Cys Glu Gln Pro Pro Ala Ser Ser Met Pro Glu
              20                  25                  30        
 Arg Pro Ser His Glu Ser Gln Pro Thr Pro Gln Met Met Pro Leu Ser
          35                  40                  45            
 Ala Pro Ser Arg Ala Glu Glu Leu Gly Gln Arg Pro Gly
      50                  55                  60    



      <210> 1177
      <211> 172
      <212> PRT
      <213> Homo sapiens


      <400> 1177
 Met Asn Ser Ser Asp Glu Glu Lys Gln Leu Gln Leu Ile Thr Ser Leu
   1               5                  10                  15    
 Lys Glu Gln Ala Ile Gly Glu Tyr Glu Asp Leu Arg Ala Glu Asn Gln
              20                  25                  30        
 Lys Thr Lys Glu Lys Cys Asp Lys Ile Arg Gln Glu Pro Asp Glu Ala
          35                  40                  45            
 Val Lys Lys Leu Glu Glu Phe Gln Lys Ile Ser His Met Val Ile Glu
      50                  55                  60                
 Glu Val Asn Phe Met Gln Asn His Leu Glu Ile Glu Lys Thr Cys Arg
  65                  70                  75                  80
 Glu Ser Ala Glu Ala Leu Ala Thr Lys Leu Asn Lys Glu Asn Lys Thr
                  85                  90                  95    
 Leu Lys Arg Ile Ser Met Leu Tyr Met Ala Lys Leu Gly Pro Asp Val
             100                 105                 110        
 Ile Thr Glu Glu Ile Asn Ile Asp Asp Glu Asp Ser Thr Thr Asp Thr
         115                 120                 125            
 Asp Gly Ala Ala Glu Thr Cys Val Ser Val Gln Cys Gln Lys Gln Ile
     130                 135                 140                
 Lys Glu Leu Arg Asp Gln Ile Val Ser Val Gln Glu Glu Lys Lys Ile
 145                 150                 155                 160
 Leu Ala Ile Glu Leu Glu Asn Leu Lys Ser Asn Ser
                 165                 170        



      <210> 1178
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 1178
 Met Val Ser Ala Ala Ala Pro Ser Leu Leu Ile Leu Leu Leu Leu Leu
   1               5                  10                  15    
 Leu Gly Ser Val Pro Ala Thr Asp Ala Leu Leu Glu Gly Ser Leu Leu
              20                  25                  30        
 Leu Ala Gln Glu Ala Gln Gly Pro Val Gly Pro Pro Glu Ser Pro Cys
          35                  40                  45            
 Ala Cys Ser Ser Val His Pro Ser Val
      50                  55        



      <210> 1179
      <211> 50
      <212> PRT
      <213> Homo sapiens


      <400> 1179
 Met Phe Cys Ser Phe Pro Leu Leu Ile Leu Gln Val Tyr Pro Thr Trp
   1               5                  10                  15    
 Lys Asn Pro Asn Trp His Leu Thr Phe His Thr Ser Val Phe Ser Phe
              20                  25                  30        
 Pro Lys Gly Val Arg Ser Leu Ala Arg Gly Ile Pro Asp His Leu His
          35                  40                  45            
 Ser Ala
      50



      <210> 1180
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 1180
 Met Gln Gln Met Met Trp Ala Gly Leu Leu Cys Pro Gln Leu Glu Trp
   1               5                  10                  15    
 Leu Gln Gly Arg Ala Cys Arg Pro Cys Gly Leu Leu Ala Ser Asp Ala
              20                  25                  30        
 Ala Ala Leu Trp Phe Arg Gly Gly Ile Ser Ala Trp Glu Asp Ser Cys
          35                  40                  45            
 Ala Val Ser Asn Ile Arg His Glu Ala Tyr Asn Cys His Leu Ser Val
      50                  55                  60                
 Phe Leu Asn Arg Cys Ala Asn Glu Leu Thr Val Gln Phe Leu Ile Ile
  65                  70                  75                  80
 Leu Ala Phe Gln Ile Met Leu Ser Cys Ala Val Ile Ala Pro Ala Val
                  85                  90                  95    
 Pro Val Phe Gln Arg Leu Thr Leu Lys Arg Ser Gly Arg Thr Ser Leu
             100                 105                 110        
 Gly Ser Thr Gly Arg Leu His Phe Cys Lys
         115                 120        



      <210> 1181
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 1181
 Met Lys Arg Leu Arg Phe Val Leu Arg Val Phe Gln Met Thr Ala Phe
   1               5                  10                  15    
 Ile Thr Gly Ala His Thr Ile Thr Asn Tyr Ser Asp Arg Arg Leu Tyr
              20                  25                  30        
 Ile Ser Pro Leu Ser His Phe Phe Met Asn Ser Gly Ser Ser Ala Gln
          35                  40                  45            
 Ser Val Leu Ser His Ser Tyr Val Ser Gln Ile Phe Phe Lys Asn Val
      50                  55                  60                
 Ser Lys Tyr Phe
  65            



      <210> 1182
      <211> 692
      <212> PRT
      <213> Homo sapiens


      <400> 1182
 Met Lys Ile Phe Cys Ser Arg Ala Asn Pro Thr Thr Gly Ser Val Glu
   1               5                  10                  15    
 Trp Leu Glu Glu Asp Glu His Tyr Asp Tyr His Gln Glu Ile Ala Arg
              20                  25                  30        
 Ser Ser Tyr Ala Asp Met Leu His Asp Lys Asp Arg Asn Val Lys Tyr
          35                  40                  45            
 Tyr Gln Gly Ile Arg Ala Ala Val Ser Arg Val Lys Asp Arg Gly Gln
      50                  55                  60                
 Lys Ala Leu Val Leu Asp Ile Gly Thr Gly Thr Gly Leu Leu Ser Met
  65                  70                  75                  80
 Met Ala Val Thr Ala Gly Ala Asp Phe Cys Tyr Ala Ile Glu Val Phe
                  85                  90                  95    
 Lys Pro Met Ala Asp Ala Ala Val Lys Ile Val Glu Lys Asn Gly Phe
             100                 105                 110        
 Ser Asp Lys Ile Lys Val Ile Asn Lys His Ser Thr Glu Val Thr Val
         115                 120                 125            
 Gly Pro Glu Gly Asp Met Pro Cys Arg Ala Asn Ile Leu Val Thr Glu
     130                 135                 140                
 Leu Phe Asp Thr Glu Leu Ile Gly Glu Gly Ala Leu Pro Ser Tyr Glu
 145                 150                 155                 160
 His Ala His Arg His Leu Val Glu Glu Asn Cys Glu Ala Val Pro His
                 165                 170                 175    
 Arg Ala Thr Val Tyr Ala Gln Leu Val Glu Ser Gly Arg Met Trp Ser
             180                 185                 190        
 Trp Asn Lys Leu Phe Pro Ile His Val Gln Thr Ser Leu Gly Glu Gln
         195                 200                 205            
 Val Ile Val Pro Pro Val Asp Val Glu Ser Cys Pro Gly Ala Pro Ser
     210                 215                 220                
 Val Cys Asp Ile Gln Leu Asn Gln Val Ser Pro Ala Asp Phe Thr Val
 225                 230                 235                 240
 Leu Ser Asp Val Leu Pro Met Phe Ser Ile Asp Phe Ser Lys Gln Val
                 245                 250                 255    
 Ser Ser Ser Ala Ala Cys His Ser Arg Arg Phe Glu Pro Leu Thr Ser
             260                 265                 270        
 Gly Arg Ala Gln Val Val Leu Ser Trp Trp Asp Ile Glu Met Asp Pro
         275                 280                 285            
 Glu Gly Lys Ile Lys Cys Thr Met Ala Pro Phe Trp Ala His Ser Asp
     290                 295                 300                
 Pro Glu Glu Met Gln Trp Arg Asp His Trp Met Gln Cys Val Tyr Phe
 305                 310                 315                 320
 Leu Pro Gln Glu Glu Pro Val Val Gln Gly Ser Ala Leu Tyr Leu Val
                 325                 330                 335    
 Ala His His Asp Asp Tyr Cys Val Trp Tyr Ser Leu Gln Arg Thr Ser
             340                 345                 350        
 Pro Glu Lys Asn Glu Arg Val Arg Gln Met Arg Pro Val Cys Asp Cys
         355                 360                 365            
 Gln Ala His Leu Leu Trp Asn Arg Pro Arg Phe Gly Glu Ile Asn Asp
     370                 375                 380                
 Gln Asp Arg Thr Asp Arg Tyr Val Gln Ala Leu Arg Thr Val Leu Lys
 385                 390                 395                 400
 Pro Asp Ser Val Cys Leu Cys Val Ser Asp Gly Ser Leu Leu Ser Val
                 405                 410                 415    
 Leu Ala His His Leu Gly Val Glu Gln Val Phe Thr Val Glu Ser Ser
             420                 425                 430        
 Ala Ala Ser His Lys Leu Leu Arg Lys Ile Phe Lys Ala Asn His Leu
         435                 440                 445            
 Glu Asp Lys Ile Asn Ile Ile Glu Lys Arg Pro Glu Leu Leu Thr Asn
     450                 455                 460                
 Glu Asp Leu Gln Gly Arg Lys Val Ser Leu Leu Leu Gly Glu Pro Phe
 465                 470                 475                 480
 Phe Thr Thr Ser Leu Leu Pro Trp His Asn Leu Tyr Phe Trp Tyr Val
                 485                 490                 495    
 Arg Thr Ala Val Asp Gln His Leu Gly Pro Gly Ala Met Val Met Pro
             500                 505                 510        
 Gln Ala Ala Ser Leu His Ala Val Val Val Glu Phe Arg Asp Leu Trp
         515                 520                 525            
 Arg Ile Arg Ser Pro Cys Gly Asp Cys Glu Gly Phe Asp Val His Ile
     530                 535                 540                
 Met Asp Asp Met Ile Lys Arg Ala Leu Asp Phe Arg Glu Ser Arg Glu
 545                 550                 555                 560
 Ala Glu Pro His Pro Leu Trp Glu Tyr Pro Cys Arg Ser Leu Ser Glu
                 565                 570                 575    
 Pro Trp Gln Ile Leu Thr Phe Asp Phe Gln Gln Pro Val Pro Leu Gln
             580                 585                 590        
 Pro Leu Cys Ala Glu Gly Thr Val Glu Leu Arg Arg Pro Gly Gln Ser
         595                 600                 605            
 His Ala Ala Val Leu Trp Met Glu Tyr His Leu Thr Pro Glu Cys Thr
     610                 615                 620                
 Leu Ser Thr Gly Leu Leu Glu Pro Ala Asp Pro Glu Gly Gly Cys Cys
 625                 630                 635                 640
 Trp Asn Pro His Cys Lys Gln Ala Val Tyr Phe Phe Ser Pro Ala Pro
                 645                 650                 655    
 Asp Pro Arg Ala Leu Leu Gly Gly Pro Arg Thr Val Ser Tyr Ala Val
             660                 665                 670        
 Glu Phe His Pro Asp Thr Gly Asp Ile Ile Met Glu Phe Arg His Ala
         675                 680                 685            
 Asp Thr Pro Asp
     690        



      <210> 1183
      <211> 468
      <212> PRT
      <213> Homo sapiens


      <400> 1183
 Met Ala Thr Ser Val Gly His Arg Cys Leu Gly Leu Leu His Gly Val
   1               5                  10                  15    
 Ala Pro Trp Arg Ser Ser Leu His Pro Cys Glu Ile Thr Ala Leu Ser
              20                  25                  30        
 Gln Ser Leu Gln Pro Leu Arg Lys Leu Pro Phe Arg Ala Phe Arg Thr
          35                  40                  45            
 Asp Ala Arg Lys Ile His Thr Ala Pro Ala Arg Thr Met Phe Leu Leu
      50                  55                  60                
 Arg Pro Leu Pro Ile Leu Leu Val Thr Gly Gly Gly Tyr Ala Gly Tyr
  65                  70                  75                  80
 Arg Gln Tyr Glu Lys Tyr Arg Glu Arg Glu Leu Glu Lys Leu Gly Leu
                  85                  90                  95    
 Glu Ile Pro Pro Lys Leu Ala Gly His Trp Glu Val Ala Leu Tyr Lys
             100                 105                 110        
 Ser Val Pro Thr Arg Leu Leu Ser Arg Ala Trp Gly Arg Leu Asn Gln
         115                 120                 125            
 Val Glu Leu Pro His Trp Leu Arg Arg Pro Val Tyr Ser Leu Tyr Ile
     130                 135                 140                
 Trp Thr Phe Gly Val Asn Met Lys Glu Ala Ala Val Glu Asp Leu His
 145                 150                 155                 160
 His Tyr Arg Asn Leu Ser Glu Phe Phe Arg Arg Lys Leu Lys Pro Gln
                 165                 170                 175    
 Ala Arg Pro Val Cys Gly Leu His Ser Val Val Arg Pro Asp Pro Phe
             180                 185                 190        
 Leu Leu Gln Glu Thr Gly Leu Phe Pro Ala Ser Pro Ala Gln Pro Pro
         195                 200                 205            
 Trp Ser Pro Ala Tyr Leu Glu Gly Ala Gly Met Thr Arg Gly Gly Gly
     210                 215                 220                
 Gly Cys Leu Leu Gly Gly Gly Asp Pro Ala Leu Pro Gly Ser Lys Pro
 225                 230                 235                 240
 Leu Leu Pro Phe Gln Ile Ser Pro Ser Asp Gly Arg Ile Leu Asn Phe
                 245                 250                 255    
 Gly Gln Val Lys Asn Cys Glu Val Glu Gln Val Lys Gly Val Thr Tyr
             260                 265                 270        
 Ser Leu Glu Ser Phe Leu Gly Pro Arg Met Cys Thr Glu Asp Leu Pro
         275                 280                 285            
 Phe Pro Pro Ala Ala Ser Cys Asp Ser Phe Lys Asn Gln Leu Val Thr
     290                 295                 300                
 Arg Glu Gly Asn Glu Leu Tyr His Cys Val Ile Tyr Leu Ala Pro Gly
 305                 310                 315                 320
 Asp Tyr His Cys Phe His Ser Pro Thr Asp Trp Thr Val Ser His Arg
                 325                 330                 335    
 Arg His Phe Pro Gly Ser Leu Met Ser Val Asn Pro Gly Met Ala Arg
             340                 345                 350        
 Trp Ile Lys Glu Leu Phe Cys His Asn Glu Arg Val Val Leu Thr Gly
         355                 360                 365            
 Asp Trp Lys His Gly Phe Phe Ser Leu Thr Ala Val Gly Ala Thr Asn
     370                 375                 380                
 Val Gly Ser Ile Arg Ile Tyr Phe Asp Arg Asp Leu His Thr Asn Ser
 385                 390                 395                 400
 Pro Arg His Ser Lys Gly Ser Tyr Asn Asp Phe Ser Phe Val Thr His
                 405                 410                 415    
 Thr Asn Arg Glu Gly Val Pro Met Arg Lys Gly Glu His Leu Gly Glu
             420                 425                 430        
 Phe Asn Leu Gly Ser Thr Ile Val Leu Ile Phe Glu Ala Pro Lys Asp
         435                 440                 445            
 Phe Asn Phe Gln Leu Lys Thr Gly Gln Lys Ile Arg Phe Gly Glu Ala
     450                 455                 460                
 Leu Gly Ser Leu
 465            



      <210> 1184
      <211> 273
      <212> PRT
      <213> Homo sapiens


      <400> 1184
 Met Ala Gln Ser Lys Leu Asp Cys Arg Ser Pro Val Gly Leu Asp Cys
   1               5                  10                  15    
 Cys Asn Cys Cys Leu Asp Leu Ala His Arg Ser Gly Leu Gln Arg Gly
              20                  25                  30        
 Ser Ser Gly Glu Asn Asn Asn Pro Gly Ser Pro Thr Val Ser Asn Phe
          35                  40                  45            
 Arg Gln Leu Gln Glu Lys Leu Val Phe Glu Asn Leu Asn Thr Asp Lys
      50                  55                  60                
 Leu Asn Ser Ile Met Arg Gln Asp Ser Leu Glu Pro Val Leu Arg Asp
  65                  70                  75                  80
 Pro Cys Tyr Leu Ile Asn Glu Gly Ile Cys Asn Arg Asn Ile Asp Gln
                  85                  90                  95    
 Thr Met Leu Ser Ile Leu Leu Phe Phe His Ser Ala Ser Gly Ala Ser
             100                 105                 110        
 Val Val Ala Ile Asp Asn Lys Ile Glu Gln Ala Met Asp Leu Val Lys
         115                 120                 125            
 Asn His Leu Met Tyr Ala Val Arg Glu Glu Val Glu Ile Leu Lys Glu
     130                 135                 140                
 Gln Ile Arg Glu Leu Val Glu Lys Asn Ser Gln Leu Glu Arg Glu Asn
 145                 150                 155                 160
 Thr Leu Leu Lys Thr Leu Ala Ser Pro Glu Gln Leu Glu Lys Phe Gln
                 165                 170                 175    
 Ser Cys Leu Ser Pro Glu Glu Pro Ala Pro Glu Ser Pro Gln Val Pro
             180                 185                 190        
 Glu Ala Pro Gly Gly Ser Ala Gly Glu Val Ala Leu Ser Ser Gly Trp
         195                 200                 205            
 Ala Glu Pro Leu Asn Leu Phe Tyr Leu Val Leu Ser Ser Leu Phe Leu
     210                 215                 220                
 Ala Pro Gln Ala Ser Ser His Glu Glu Asn Phe Thr Pro Ser Thr Ala
 225                 230                 235                 240
 Gly Ala Lys Arg Cys Pro Lys Asp Ile Gly His Leu Gly Pro Leu Gln
                 245                 250                 255    
 Arg Gln Thr Pro Asp Lys Ser Arg Ser Leu Glu Ala Glu Leu His Gly
             260                 265                 270        
 Ala
    



      <210> 1185
      <211> 653
      <212> PRT
      <213> Homo sapiens


      <400> 1185
 Met Glu Pro Ser Gly Ser Glu Gln Leu Phe Glu Asp Pro Asp Pro Gly
   1               5                  10                  15    
 Gly Lys Ser Gln Asp Ala Glu Ala Arg Lys Gln Thr Glu Ser Glu Gln
              20                  25                  30        
 Lys Leu Ser Lys Met Thr His Asn Ala Leu Glu Asn Ile Asn Val Ile
          35                  40                  45            
 Gly Gln Gly Leu Lys His Leu Phe Gln His Gln Arg Arg Arg Ser Ser
      50                  55                  60                
 Val Ser Pro His Asp Val Gln Gln Ile Gln Ala Asp Pro Glu Pro Glu
  65                  70                  75                  80
 Met Asp Leu Glu Ser Gln Asn Ala Cys Ala Glu Ile Asp Gly Val Pro
                  85                  90                  95    
 Thr His Pro Thr Ala Leu Asn Arg Val Leu Gln Gln Ile Arg Val Pro
             100                 105                 110        
 Pro Lys Met Lys Arg Gly Thr Ser Leu His Ser Arg Arg Gly Lys Pro
         115                 120                 125            
 Glu Ala Pro Lys Gly Ser Pro Gln Ile Asn Arg Lys Ser Gly Gln Glu
     130                 135                 140                
 Met Thr Ala Val Met Gln Ser Gly Arg Pro Arg Ser Ser Ser Thr Thr
 145                 150                 155                 160
 Asp Ala Pro Thr Gly Ser Ala Met Met Glu Ile Ala Cys Ala Ala Ala
                 165                 170                 175    
 Ala Ala Ala Ala Ala Cys Leu Pro Gly Glu Glu Gly Thr Ala Glu Arg
             180                 185                 190        
 Ile Glu Arg Leu Glu Val Ser Ser Leu Ala Gln Thr Ser Ser Ala Val
         195                 200                 205            
 Ala Ser Ser Thr Asp Gly Ser Ile His Thr Asp Ser Val Asp Gly Thr
     210                 215                 220                
 Pro Asp Pro Gln Arg Thr Lys Ala Ala Ile Ala His Leu Gln Gln Lys
 225                 230                 235                 240
 Ile Leu Lys Leu Thr Glu Gln Ile Lys Ile Ala Gln Thr Ala Arg Asp
                 245                 250                 255    
 Asp Asn Val Ala Glu Tyr Leu Lys Leu Ala Asn Ser Ala Asp Lys Gln
             260                 265                 270        
 Gln Ala Ala Arg Ile Lys Gln Val Phe Glu Lys Lys Asn Gln Lys Ser
         275                 280                 285            
 Ala Gln Thr Ile Leu Gln Leu Gln Lys Lys Leu Glu His Tyr His Arg
     290                 295                 300                
 Lys Leu Arg Glu Val Glu Gln Asn Gly Ile Pro Arg Gln Pro Lys Asp
 305                 310                 315                 320
 Val Phe Arg Asp Met His Gln Gly Leu Lys Asp Val Gly Ala Lys Val
                 325                 330                 335    
 Thr Gly Phe Ser Glu Gly Val Val Asp Ser Val Lys Gly Gly Phe Ser
             340                 345                 350        
 Ser Phe Ser Gln Ala Thr His Ser Ala Ala Gly Ala Val Val Ser Lys
         355                 360                 365            
 Pro Arg Glu Ile Ala Ser Leu Ile Arg Asn Lys Phe Gly Ser Ala Asp
     370                 375                 380                
 Asn Ile Pro Asn Leu Lys Asp Ser Leu Glu Glu Gly Gln Val Asp Asp
 385                 390                 395                 400
 Ala Gly Lys Ala Leu Gly Val Ile Ser Asn Phe Gln Ser Ser Pro Lys
                 405                 410                 415    
 Tyr Gly Ser Glu Glu Asp Cys Ser Ser Ala Thr Ser Gly Ser Val Gly
             420                 425                 430        
 Ala Asn Ser Thr Thr Gly Gly Ile Ala Val Gly Ala Ser Ser Ser Lys
         435                 440                 445            
 Thr Asn Thr Leu Asp Met Gln Ser Ser Gly Phe Asp Ala Leu Leu His
     450                 455                 460                
 Glu Ile Gln Glu Ile Arg Glu Thr Gln Ala Arg Leu Glu Glu Ser Phe
 465                 470                 475                 480
 Glu Thr Leu Lys Glu His Tyr Gln Arg Asp Tyr Ser Leu Ile Met Gln
                 485                 490                 495    
 Thr Leu Gln Glu Glu Arg Tyr Arg Cys Glu Arg Leu Glu Glu Gln Leu
             500                 505                 510        
 Asn Asp Leu Thr Glu Leu His Gln Asn Glu Ile Leu Asn Leu Lys Gln
         515                 520                 525            
 Glu Leu Ala Ser Met Glu Glu Lys Ile Ala Tyr Gln Ser Tyr Glu Arg
     530                 535                 540                
 Ala Arg Asp Ile Gln Glu Ala Leu Glu Ala Cys Gln Thr Arg Ile Ser
 545                 550                 555                 560
 Lys Met Glu Leu Gln Gln Gln Gln Gln Gln Val Val Gln Leu Glu Gly
                 565                 570                 575    
 Leu Glu Asn Ala Thr Ala Arg Asn Leu Leu Gly Lys Leu Ile Asn Ile
             580                 585                 590        
 Leu Leu Ala Val Met Ala Val Leu Leu Val Phe Val Ser Thr Val Ala
         595                 600                 605            
 Asn Cys Val Val Pro Leu Met Lys Thr Arg Asn Arg Thr Phe Ser Thr
     610                 615                 620                
 Leu Phe Leu Val Val Phe Ile Ala Phe Leu Trp Lys His Trp Asp Ala
 625                 630                 635                 640
 Leu Phe Ser Tyr Val Glu Arg Phe Phe Ser Ser Pro Arg
                 645                 650            



      <210> 1186
      <211> 496
      <212> PRT
      <213> Homo sapiens


      <400> 1186
 Met Ala Leu Trp Arg Gly Ser Ala Tyr Ala Gly Phe Leu Ala Leu Ala
   1               5                  10                  15    
 Val Gly Cys Val Phe Leu Leu Glu Pro Glu Leu Pro Gly Ser Ala Leu
              20                  25                  30        
 Arg Ser Leu Trp Ser Ser Leu Cys Leu Gly Pro Ala Pro Ala Pro Pro
          35                  40                  45            
 Gly Pro Val Ser Pro Glu Gly Arg Leu Ala Ala Ala Trp Asp Ala Leu
      50                  55                  60                
 Ile Val Arg Pro Val Arg Arg Trp Arg Arg Val Ala Val Gly Val Asn
  65                  70                  75                  80
 Ala Cys Val Asp Val Val Leu Ser Gly Val Lys Leu Leu Gln Ala Leu
                  85                  90                  95    
 Gly Leu Ser Pro Gly Asn Gly Lys Asp His Ser Ile Leu His Ser Arg
             100                 105                 110        
 Asn Asp Leu Glu Glu Ala Phe Ile His Phe Met Gly Lys Gly Ala Ala
         115                 120                 125            
 Ala Glu Arg Phe Phe Ser Asp Lys Glu Thr Phe His Asp Ile Ala Gln
     130                 135                 140                
 Val Ala Ser Glu Phe Pro Gly Ala Gln His Tyr Val Gly Gly Asn Ala
 145                 150                 155                 160
 Ala Leu Ile Gly Gln Lys Phe Ala Ala Asn Ser Asp Leu Lys Val Leu
                 165                 170                 175    
 Leu Cys Gly Pro Val Gly Pro Lys Leu His Glu Leu Leu Asp Asp Asn
             180                 185                 190        
 Val Phe Val Pro Pro Glu Ser Leu Gln Glu Val Asp Glu Phe His Leu
         195                 200                 205            
 Ile Leu Glu Tyr Gln Ala Gly Glu Glu Trp Gly Gln Leu Lys Ala Pro
     210                 215                 220                
 His Ala Asn Arg Phe Ile Phe Ser His Asp Leu Ser Asn Gly Ala Met
 225                 230                 235                 240
 Asn Met Leu Glu Val Phe Val Ser Ser Leu Glu Glu Phe Gln Pro Asp
                 245                 250                 255    
 Leu Val Val Leu Ser Gly Leu His Met Met Glu Gly Gln Ser Lys Glu
             260                 265                 270        
 Leu Gln Arg Lys Arg Leu Leu Glu Val Val Thr Ser Ile Ser Asp Ile
         275                 280                 285            
 Pro Thr Gly Ile Pro Val His Leu Glu Leu Ala Ser Met Thr Asn Arg
     290                 295                 300                
 Glu Leu Met Ser Ser Ile Val His Gln Val Phe Pro Ala Val Thr Ser
 305                 310                 315                 320
 Leu Gly Leu Asn Glu Gln Glu Leu Leu Phe Leu Thr Gln Ser Ala Ser
                 325                 330                 335    
 Gly Pro His Ser Ser Leu Ser Ser Trp Asn Gly Val Pro Asp Val Gly
             340                 345                 350        
 Met Val Ser Asp Ile Leu Phe Trp Ile Leu Lys Glu His Gly Arg Ser
         355                 360                 365            
 Lys Ser Arg Ala Ser Asp Leu Thr Arg Ile His Phe His Thr Leu Val
     370                 375                 380                
 Tyr His Ile Leu Ala Thr Val Asp Gly His Trp Ala Asn Gln Leu Ala
 385                 390                 395                 400
 Ala Val Ala Ala Gly Ala Arg Val Ala Gly Thr Gln Ala Cys Ala Thr
                 405                 410                 415    
 Glu Thr Ile Asp Thr Ser Arg Val Ser Leu Arg Ala Pro Gln Glu Phe
             420                 425                 430        
 Met Thr Ser His Ser Glu Ala Gly Ser Arg Ile Val Leu Asn Pro Asn
         435                 440                 445            
 Lys Pro Val Val Glu Trp His Arg Glu Gly Ile Ser Phe His Phe Thr
     450                 455                 460                
 Pro Val Leu Val Cys Lys Asp Pro Ile Arg Thr Val Gly Leu Gly Asp
 465                 470                 475                 480
 Ala Ile Ser Ala Glu Gly Leu Phe Tyr Ser Glu Val His Pro His Tyr
                 485                 490                 495    





      <210> 1187
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 1187
 Met Gln Glu Met Asn Asp Lys Ala Ile Phe Lys Thr Leu Phe Leu Phe
   1               5                  10                  15    
 Phe Pro Gln Ser Leu Val Leu Ile Ser Lys Leu Pro Tyr Ile His Phe
              20                  25                  30        
 Phe His Thr Val Leu Lys Gln Ile Ala Pro Glu Tyr Phe Glu Lys Asn
          35                  40                  45            
 Glu Pro Tyr Leu Glu Ala Ala Cys Asn Asp Val Asp Arg Trp Pro Ala
      50                  55                  60                
 Pro Val Pro Gly Lys Thr Leu His Leu Pro Ile Met Gly Val Val Met
  65                  70                  75                  80
 Lys Val Arg Ile Pro Thr Cys His Asp Lys Pro Gly Thr Thr Gln Ile
                  85                  90                  95    
 Val Gln Leu Thr Gln Gln Val Asp Thr Asn Ile Ser Val Ile Leu Pro
             100                 105                 110        
 Thr Val His Glu Gly Asp Ile Phe Arg Cys Phe Cys Pro Val Phe Leu
         115                 120                 125            
 His Ser Gln Met Leu Trp Glu Leu Val Leu Leu Gly Glu Pro Leu Val
     130                 135                 140                
 Val Met Ala Pro Ser Pro Ser Glu Ser Ser Glu Thr Val Leu Ala Leu
 145                 150                 155                 160
 Val Asn Cys Ile Ser Pro Leu Lys Tyr Phe Ser Asp Phe Arg Pro Tyr
                 165                 170                 175    
 Phe Thr Ile His Asp Ser Glu Phe Lys Glu Tyr Thr Thr Arg Thr Gln
             180                 185                 190        
 Ala Pro
        



      <210> 1188
      <211> 892
      <212> PRT
      <213> Homo sapiens


      <400> 1188
 Met Arg Lys Val Lys Lys Leu Arg Leu Asp Lys Glu Asn Thr Gly Ser
   1               5                  10                  15    
 Trp Arg Ser Phe Ser Leu Asn Ser Glu Gly Ala Glu Arg Met Ala Thr
              20                  25                  30        
 Thr Gly Thr Pro Thr Ala Asp Arg Gly Asp Ala Ala Ala Thr Asp Asp
          35                  40                  45            
 Pro Ala Ala Arg Phe Gln Val Gln Lys His Ser Trp Asp Gly Leu Arg
      50                  55                  60                
 Ser Ile Ile His Gly Ser Arg Lys Tyr Ser Gly Leu Ile Val Asn Lys
  65                  70                  75                  80
 Ala Pro His Asp Phe Gln Phe Val Gln Lys Thr Asp Glu Ser Gly Pro
                  85                  90                  95    
 His Ser His Arg Leu Tyr Tyr Leu Gly Met Pro Tyr Gly Ser Arg Glu
             100                 105                 110        
 Asn Ser Leu Leu Tyr Ser Glu Ile Pro Lys Lys Val Arg Lys Glu Ala
         115                 120                 125            
 Leu Leu Leu Leu Ser Trp Lys Gln Met Leu Asp His Phe Gln Ala Thr
     130                 135                 140                
 Pro His His Gly Val Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg
 145                 150                 155                 160
 Lys Arg Leu Gly Val Phe Gly Ile Thr Ser Tyr Asp Phe His Ser Glu
                 165                 170                 175    
 Ser Gly Leu Phe Leu Phe Gln Ala Ser Asn Ser Leu Phe His Cys Arg
             180                 185                 190        
 Asp Gly Gly Lys Asn Gly Phe Met Val Ser Pro Met Lys Pro Leu Glu
         195                 200                 205            
 Ile Lys Thr Gln Cys Ser Gly Pro Arg Met Asp Pro Lys Ile Cys Pro
     210                 215                 220                
 Ala Asp Pro Ala Phe Phe Ser Phe Ile Asn Asn Ser Asp Leu Trp Val
 225                 230                 235                 240
 Ala Asn Ile Glu Thr Gly Glu Glu Arg Arg Leu Thr Phe Cys His Gln
                 245                 250                 255    
 Gly Leu Ser Asn Val Leu Asp Asp Pro Lys Ser Ala Gly Val Ala Thr
             260                 265                 270        
 Phe Val Ile Gln Glu Glu Phe Asp Arg Phe Thr Gly Tyr Trp Trp Cys
         275                 280                 285            
 Pro Thr Ala Ser Trp Glu Gly Ser Glu Gly Leu Lys Thr Leu Arg Ile
     290                 295                 300                
 Leu Tyr Glu Glu Val Asp Glu Ser Glu Val Glu Val Ile His Val Pro
 305                 310                 315                 320
 Ser Pro Ala Leu Glu Glu Arg Lys Thr Asp Ser Tyr Arg Tyr Pro Arg
                 325                 330                 335    
 Thr Gly Ser Lys Asn Pro Lys Ile Ala Leu Lys Leu Ala Glu Phe Gln
             340                 345                 350        
 Thr Asp Ser Gln Gly Lys Ile Val Ser Thr Gln Glu Lys Glu Leu Val
         355                 360                 365            
 Gln Pro Phe Ser Ser Leu Phe Pro Lys Val Glu Tyr Ile Ala Arg Ala
     370                 375                 380                
 Gly Trp Thr Arg Asp Gly Lys Tyr Ala Trp Ala Met Phe Leu Asp Arg
 385                 390                 395                 400
 Pro Gln Gln Trp Leu Gln Leu Val Leu Leu Pro Pro Ala Leu Phe Ile
                 405                 410                 415    
 Pro Ser Thr Glu Asn Glu Glu Gln Arg Leu Ala Ser Ala Arg Ala Val
             420                 425                 430        
 Pro Arg Asn Val Gln Pro Tyr Val Val Tyr Glu Glu Val Thr Asn Val
         435                 440                 445            
 Trp Ile Asn Val His Asp Ile Phe Tyr Pro Phe Pro Gln Ser Glu Gly
     450                 455                 460                
 Glu Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu Cys Lys Thr Gly Phe
 465                 470                 475                 480
 Cys His Leu Tyr Lys Val Thr Ala Val Leu Lys Ser Gln Gly Tyr Asp
                 485                 490                 495    
 Trp Ser Glu Pro Phe Ser Pro Gly Glu Asp Glu Phe Lys Cys Pro Ile
             500                 505                 510        
 Lys Glu Glu Ile Ala Leu Thr Ser Gly Glu Trp Glu Val Leu Ala Arg
         515                 520                 525            
 His Gly Ser Lys Ile Trp Val Asn Glu Glu Thr Lys Leu Val Tyr Phe
     530                 535                 540                
 Gln Gly Thr Lys Asp Thr Pro Leu Glu His His Leu Tyr Val Val Ser
 545                 550                 555                 560
 Tyr Glu Ala Ala Gly Glu Ile Val Arg Leu Thr Thr Pro Gly Phe Ser
                 565                 570                 575    
 His Ser Cys Ser Met Ser Gln Asn Phe Asp Met Phe Val Ser His Tyr
             580                 585                 590        
 Ser Ser Val Ser Thr Pro Pro Cys Val His Val Tyr Lys Leu Ser Gly
         595                 600                 605            
 Pro Asp Asp Asp Pro Leu His Lys Gln Pro Arg Phe Trp Ala Ser Met
     610                 615                 620                
 Met Glu Ala Ala Ser Cys Pro Pro Asp Tyr Val Pro Pro Glu Ile Phe
 625                 630                 635                 640
 His Phe His Thr Arg Ser Asp Val Arg Leu Tyr Gly Met Ile Tyr Lys
                 645                 650                 655    
 Pro His Ala Leu Gln Pro Gly Lys Lys His Pro Thr Val Leu Phe Val
             660                 665                 670        
 Tyr Gly Gly Pro Gln Val Gln Leu Val Asn Asn Ser Phe Lys Gly Ile
         675                 680                 685            
 Lys Tyr Leu Arg Leu Asn Thr Leu Ala Ser Leu Gly Tyr Ala Val Val
     690                 695                 700                
 Val Ile Asp Gly Arg Gly Ser Cys Gln Arg Gly Leu Arg Phe Glu Gly
 705                 710                 715                 720
 Ala Leu Lys Asn Gln Met Gly Gln Val Glu Ile Glu Asp Gln Val Glu
                 725                 730                 735    
 Gly Leu Gln Phe Val Ala Glu Lys Tyr Gly Phe Ile Asp Leu Ser Arg
             740                 745                 750        
 Val Ala Ile His Gly Trp Ser Tyr Gly Gly Phe Leu Ser Leu Met Gly
         755                 760                 765            
 Leu Ile His Lys Pro Gln Val Phe Lys Val Ala Ile Ala Gly Ala Pro
     770                 775                 780                
 Val Thr Val Trp Met Ala Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met
 785                 790                 795                 800
 Asp Val Pro Glu Asn Asn Gln His Gly Tyr Glu Ala Gly Ser Val Ala
                 805                 810                 815    
 Leu His Val Glu Lys Leu Pro Asn Glu Pro Asn Arg Leu Leu Ile Leu
             820                 825                 830        
 His Gly Phe Leu Asp Glu Asn Val His Phe Phe His Thr Asn Phe Leu
         835                 840                 845            
 Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln Leu Gln Ile Tyr
     850                 855                 860                
 Pro Asn Glu Arg His Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr
 865                 870                 875                 880
 Glu Val Thr Leu Leu His Phe Leu Gln Glu Tyr Leu
                 885                 890        



      <210> 1189
      <211> 854
      <212> PRT
      <213> Homo sapiens


      <400> 1189
 Met Arg Lys Val Lys Lys Leu Arg Leu Asp Lys Glu Asn Thr Gly Ser
   1               5                  10                  15    
 Trp Arg Ser Phe Ser Leu Asn Ser Glu Gly Ala Glu Arg Met Ala Thr
              20                  25                  30        
 Thr Gly Thr Pro Thr Ala Asp Arg Gly Asp Ala Ala Ala Thr Asp Asp
          35                  40                  45            
 Pro Ala Ala Arg Phe Gln Val Gln Lys His Ser Trp Asp Gly Leu Arg
      50                  55                  60                
 Ser Ile Ile His Gly Ser Arg Lys Tyr Ser Gly Leu Ile Val Asn Lys
  65                  70                  75                  80
 Ala Pro His Asp Phe Gln Phe Val Gln Lys Thr Asp Glu Ser Gly Pro
                  85                  90                  95    
 His Ser His Arg Leu Tyr Tyr Leu Gly Met Pro Tyr Gly Ser Arg Glu
             100                 105                 110        
 Asn Ser Leu Leu Tyr Ser Glu Ile Pro Lys Lys Val Arg Lys Glu Ala
         115                 120                 125            
 Leu Leu Leu Leu Ser Trp Lys Gln Met Leu Asp His Phe Gln Ala Thr
     130                 135                 140                
 Pro His His Gly Val Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg
 145                 150                 155                 160
 Lys Arg Leu Gly Val Phe Gly Ile Thr Ser Tyr Asp Phe His Ser Glu
                 165                 170                 175    
 Ser Gly Leu Phe Leu Phe Gln Ala Ser Asn Ser Leu Phe His Cys Arg
             180                 185                 190        
 Asp Gly Gly Lys Asn Gly Phe Met Val Ser Pro Met Lys Pro Leu Glu
         195                 200                 205            
 Ile Lys Thr Gln Cys Ser Gly Pro Arg Met Asp Pro Lys Ile Cys Pro
     210                 215                 220                
 Ala Asp Pro Ala Phe Phe Ser Phe Ile Asn Asn Ser Asp Leu Trp Val
 225                 230                 235                 240
 Ala Asn Ile Glu Thr Gly Glu Glu Arg Arg Leu Thr Phe Cys His Gln
                 245                 250                 255    
 Gly Leu Ser Asn Val Leu Asp Asp Pro Lys Ser Ala Gly Val Ala Thr
             260                 265                 270        
 Phe Val Ile Gln Glu Glu Phe Asp Arg Phe Thr Gly Tyr Trp Trp Cys
         275                 280                 285            
 Pro Thr Ala Ser Trp Glu Gly Ser Glu Gly Leu Lys Thr Leu Arg Ile
     290                 295                 300                
 Leu Tyr Glu Glu Val Asp Glu Ser Glu Val Glu Val Ile His Val Pro
 305                 310                 315                 320
 Ser Pro Ala Leu Glu Glu Arg Lys Thr Asp Ser Tyr Arg Tyr Pro Arg
                 325                 330                 335    
 Thr Gly Ser Lys Asn Pro Lys Ile Ala Leu Lys Leu Ala Glu Phe Gln
             340                 345                 350        
 Thr Asp Ser Gln Gly Lys Ile Val Ser Thr Gln Glu Lys Glu Leu Val
         355                 360                 365            
 Gln Pro Phe Ser Ser Leu Phe Pro Lys Val Glu Tyr Ile Ala Arg Ala
     370                 375                 380                
 Gly Trp Thr Arg Asp Gly Lys Tyr Ala Trp Ala Met Phe Leu Asp Arg
 385                 390                 395                 400
 Pro Gln Gln Trp Leu Gln Leu Val Leu Leu Pro Pro Ala Leu Phe Ile
                 405                 410                 415    
 Pro Ser Thr Glu Asn Glu Glu Gln Arg Leu Ala Ser Ala Arg Ala Val
             420                 425                 430        
 Pro Arg Asn Val Gln Pro Tyr Val Val Tyr Glu Glu Val Thr Asn Val
         435                 440                 445            
 Trp Ile Asn Val His Asp Ile Phe Tyr Pro Phe Pro Gln Ser Glu Gly
     450                 455                 460                
 Glu Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu Cys Lys Thr Gly Phe
 465                 470                 475                 480
 Cys His Leu Tyr Lys Val Thr Ala Val Leu Lys Ser Gln Gly Tyr Asp
                 485                 490                 495    
 Trp Ser Glu Pro Phe Ser Pro Gly Glu Asp Glu Phe Lys Cys Pro Ile
             500                 505                 510        
 Lys Glu Glu Ile Ala Leu Thr Ser Gly Glu Trp Glu Val Leu Ala Arg
         515                 520                 525            
 His Gly Ser Lys Ile Trp Val Asn Glu Glu Thr Lys Leu Val Tyr Phe
     530                 535                 540                
 Gln Gly Thr Lys Asp Thr Pro Leu Glu His His Leu Tyr Val Val Ser
 545                 550                 555                 560
 Tyr Glu Ala Ala Gly Glu Ile Val Arg Leu Thr Thr Pro Gly Phe Ser
                 565                 570                 575    
 His Ser Cys Ser Met Ser Gln Asn Phe Asp Met Phe Val Ser His Tyr
             580                 585                 590        
 Ser Ser Val Ser Thr Pro Pro Cys Val His Val Tyr Lys Leu Ser Gly
         595                 600                 605            
 Pro Asp Asp Asp Pro Leu His Lys Gln Pro Arg Phe Trp Ala Ser Met
     610                 615                 620                
 Met Glu Ala Ala Ser Cys Pro Pro Asp Tyr Val Pro Pro Glu Ile Phe
 625                 630                 635                 640
 His Phe His Thr Arg Ser Asp Val Arg Leu Tyr Gly Met Ile Tyr Lys
                 645                 650                 655    
 Pro His Ala Leu Gln Pro Gly Lys Lys His Pro Thr Val Leu Phe Val
             660                 665                 670        
 Tyr Gly Gly Pro Gln Val Gln Leu Val Asn Asn Ser Phe Lys Gly Ile
         675                 680                 685            
 Lys Tyr Leu Arg Leu Asn Thr Leu Ala Ser Leu Gly Tyr Ala Val Val
     690                 695                 700                
 Val Ile Asp Gly Arg Gly Ser Cys Gln Arg Gly Leu Arg Phe Glu Gly
 705                 710                 715                 720
 Ala Leu Lys Asn Gln Met Gly Gln Val Glu Ile Glu Asp Gln Val Glu
                 725                 730                 735    
 Gly Leu Gln Phe Val Ala Glu Lys Tyr Gly Phe Ile Asp Leu Ser Arg
             740                 745                 750        
 Val Ala Ile His Gly Trp Ser Tyr Gly Gly Phe Leu Ser Leu Met Gly
         755                 760                 765            
 Leu Ile His Lys Pro Gln Val Phe Lys Val Ala Ile Ala Gly Ala Pro
     770                 775                 780                
 Val Thr Val Pro Asn Arg Leu Leu Ile Leu His Gly Phe Leu Asp Glu
 785                 790                 795                 800
 Asn Val His Phe Phe His Thr Asn Phe Leu Val Ser Gln Leu Ile Arg
                 805                 810                 815    
 Ala Gly Lys Pro Tyr Gln Leu Gln Ile Tyr Pro Asn Glu Arg His Ser
             820                 825                 830        
 Ile Arg Cys Pro Glu Ser Gly Glu His Tyr Glu Val Thr Leu Leu His
         835                 840                 845            
 Phe Leu Gln Glu Tyr Leu
     850                



      <210> 1190
      <211> 879
      <212> PRT
      <213> Homo sapiens


      <400> 1190
 Met Arg Lys Val Lys Lys Leu Arg Leu Asp Lys Glu Asn Thr Gly Ser
   1               5                  10                  15    
 Trp Arg Ser Phe Ser Leu Asn Ser Glu Gly Ala Glu Arg Met Ala Thr
              20                  25                  30        
 Thr Gly Thr Pro Thr Ala Asp Arg Gly Asp Ala Ala Ala Thr Asp Asp
          35                  40                  45            
 Pro Ala Ala Arg Phe Gln Val Gln Lys His Ser Trp Asp Gly Leu Arg
      50                  55                  60                
 Ser Ile Ile His Gly Ser Arg Lys Tyr Ser Gly Leu Ile Val Asn Lys
  65                  70                  75                  80
 Ala Pro His Asp Phe Gln Phe Val Gln Lys Thr Asp Glu Ser Gly Pro
                  85                  90                  95    
 His Ser His Arg Leu Tyr Tyr Leu Gly Met Pro Tyr Gly Ser Arg Glu
             100                 105                 110        
 Asn Ser Leu Leu Tyr Ser Glu Ile Pro Lys Lys Val Arg Lys Glu Ala
         115                 120                 125            
 Leu Leu Leu Leu Ser Trp Lys Gln Met Leu Asp His Phe Gln Ala Thr
     130                 135                 140                
 Pro His His Gly Val Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg
 145                 150                 155                 160
 Lys Arg Leu Gly Val Phe Gly Ile Thr Ser Tyr Asp Phe His Ser Glu
                 165                 170                 175    
 Ser Gly Leu Phe Leu Phe Gln Ala Ser Asn Ser Leu Phe His Cys Arg
             180                 185                 190        
 Asp Gly Gly Lys Asn Gly Phe Met Val Ser Pro Met Lys Pro Leu Glu
         195                 200                 205            
 Ile Lys Thr Gln Cys Ser Gly Pro Arg Met Asp Pro Lys Ile Cys Pro
     210                 215                 220                
 Ala Asp Pro Ala Phe Phe Ser Phe Ile Asn Asn Ser Asp Leu Trp Val
 225                 230                 235                 240
 Ala Asn Ile Glu Thr Gly Glu Glu Arg Arg Leu Thr Phe Cys His Gln
                 245                 250                 255    
 Gly Leu Ser Asn Val Leu Asp Asp Pro Lys Ser Ala Gly Val Ala Thr
             260                 265                 270        
 Phe Val Ile Gln Glu Glu Phe Asp Arg Phe Thr Gly Tyr Trp Trp Cys
         275                 280                 285            
 Pro Thr Ala Ser Trp Glu Gly Ser Glu Gly Leu Lys Thr Leu Arg Ile
     290                 295                 300                
 Leu Tyr Glu Glu Val Asp Glu Ser Glu Val Glu Val Ile His Val Pro
 305                 310                 315                 320
 Ser Pro Ala Leu Glu Glu Arg Lys Thr Asp Ser Tyr Arg Tyr Pro Arg
                 325                 330                 335    
 Thr Gly Ser Lys Asn Pro Lys Ile Ala Leu Lys Leu Ala Glu Phe Gln
             340                 345                 350        
 Thr Asp Ser Gln Gly Lys Ile Val Ser Thr Gln Glu Lys Glu Leu Val
         355                 360                 365            
 Gln Pro Phe Ser Ser Leu Phe Pro Lys Val Glu Tyr Ile Ala Arg Ala
     370                 375                 380                
 Gly Trp Thr Arg Asp Gly Lys Tyr Ala Trp Ala Met Phe Leu Asp Arg
 385                 390                 395                 400
 Pro Gln Gln Trp Leu Gln Leu Val Leu Leu Pro Pro Ala Leu Phe Ile
                 405                 410                 415    
 Pro Ser Thr Glu Asn Glu Glu Gln Arg Leu Ala Ser Ala Arg Ala Val
             420                 425                 430        
 Pro Arg Asn Val Gln Pro Tyr Val Val Tyr Glu Glu Val Thr Asn Val
         435                 440                 445            
 Trp Ile Asn Val His Asp Ile Phe Tyr Pro Phe Pro Gln Ser Glu Gly
     450                 455                 460                
 Glu Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu Cys Lys Thr Gly Phe
 465                 470                 475                 480
 Cys His Leu Tyr Lys Val Thr Ala Val Leu Lys Ser Gln Gly Tyr Asp
                 485                 490                 495    
 Trp Ser Glu Pro Phe Ser Pro Gly Glu Asp Glu Phe Lys Cys Pro Ile
             500                 505                 510        
 Lys Glu Glu Ile Ala Leu Thr Ser Gly Glu Trp Glu Val Leu Ala Arg
         515                 520                 525            
 His Gly Ser Lys Gly Thr Lys Asp Thr Pro Leu Glu His His Leu Tyr
     530                 535                 540                
 Val Val Ser Tyr Glu Ala Ala Gly Glu Ile Val Arg Leu Thr Thr Pro
 545                 550                 555                 560
 Gly Phe Ser His Ser Cys Ser Met Ser Gln Asn Phe Asp Met Phe Val
                 565                 570                 575    
 Ser His Tyr Ser Ser Val Ser Thr Pro Pro Cys Val His Val Tyr Lys
             580                 585                 590        
 Leu Ser Gly Pro Asp Asp Asp Pro Leu His Lys Gln Pro Arg Phe Trp
         595                 600                 605            
 Ala Ser Met Met Glu Ala Ala Ser Cys Pro Pro Asp Tyr Val Pro Pro
     610                 615                 620                
 Glu Ile Phe His Phe His Thr Arg Ser Asp Val Arg Leu Tyr Gly Met
 625                 630                 635                 640
 Ile Tyr Lys Pro His Ala Leu Gln Pro Gly Lys Lys His Pro Thr Val
                 645                 650                 655    
 Leu Phe Val Tyr Gly Gly Pro Gln Val Gln Leu Val Asn Asn Ser Phe
             660                 665                 670        
 Lys Gly Ile Lys Tyr Leu Arg Leu Asn Thr Leu Ala Ser Leu Gly Tyr
         675                 680                 685            
 Ala Val Val Val Ile Asp Gly Arg Gly Ser Cys Gln Arg Gly Leu Arg
     690                 695                 700                
 Phe Glu Gly Ala Leu Lys Asn Gln Met Gly Gln Val Glu Ile Glu Asp
 705                 710                 715                 720
 Gln Val Glu Gly Leu Gln Phe Val Ala Glu Lys Tyr Gly Phe Ile Asp
                 725                 730                 735    
 Leu Ser Arg Val Ala Ile His Gly Trp Ser Tyr Gly Gly Phe Leu Ser
             740                 745                 750        
 Leu Met Gly Leu Ile His Lys Pro Gln Val Phe Lys Val Ala Ile Ala
         755                 760                 765            
 Gly Ala Pro Val Thr Val Trp Met Ala Tyr Asp Thr Gly Tyr Thr Glu
     770                 775                 780                
 Arg Tyr Met Asp Val Pro Glu Asn Asn Gln His Gly Tyr Glu Ala Gly
 785                 790                 795                 800
 Ser Val Ala Leu His Val Glu Lys Leu Pro Asn Glu Pro Asn Arg Leu
                 805                 810                 815    
 Leu Ile Leu His Gly Phe Leu Asp Glu Asn Val His Phe Phe His Thr
             820                 825                 830        
 Asn Phe Leu Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln Leu
         835                 840                 845            
 Gln Ile Tyr Pro Asn Glu Arg His Ser Ile Arg Cys Pro Glu Ser Gly
     850                 855                 860                
 Glu His Tyr Glu Val Thr Leu Leu His Phe Leu Gln Glu Tyr Leu
 865                 870                 875                



      <210> 1191
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 1191
 Met Ser Asp Lys Lys Asp Lys Asp Pro Val Asn Lys Ser Gly Gly Lys
   1               5                  10                  15    
 Ala Lys Lys Lys Lys Trp Ser Lys Gly Lys Val Arg Asp Lys Leu Asn
              20                  25                  30        
 Asn Leu Val Leu Phe Asp Lys Ala Thr Tyr Asp Lys Leu Cys Lys Glu
          35                  40                  45            
 Val Pro Asn Tyr Lys Leu Ile Thr Pro Ala Val Val Ser Glu Arg Leu
      50                  55                  60                
 Lys Ile Arg Gly Ser Leu Ala Arg Ala Ala Leu Gln Glu Leu Leu Ser
  65                  70                  75                  80
 Lys Gly Leu Ile Lys Leu Val Ser Lys His Arg Ala Gln Val Ile Tyr
                  85                  90                  95    
 Thr Arg Asn Thr Lys Gly Gly Asp Ala Pro Ala Ala Gly Glu Asp Ala
             100                 105                 110        





      <210> 1192
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 1192
 Met Leu Leu Pro Arg Lys Leu Thr Leu Ser Tyr Phe Leu Ala Leu Ile
   1               5                  10                  15    
 Ile Ala Gln Lys Glu Gln Gly Leu Leu Arg Asn Arg Gly Ser Val Gln
              20                  25                  30        
 Pro Glu Gly Met His Arg Ala Glu Glu Asp Pro Cys Gly Cys Gly Leu
          35                  40                  45            
 Phe Ser Arg Pro Lys Asp Lys Ala Val Cys Ala Gly Leu Ile Cys Thr
      50                  55                  60                
 Ala Leu Ala Arg Met Ala Leu Leu Arg Glu Thr Asn Arg Ser Asn Ala
  65                  70                  75                  80
 Lys Leu Pro Ser Gln Phe Gln Ser Gln Arg Gln Ala Arg Ala Thr Val
                  85                  90                  95    
 Gln Thr Gln Leu Pro Met Ser Thr Lys Lys Arg Arg Lys Leu Glu Met
             100                 105                 110        
 Gln Leu Val Leu Pro Cys Trp Pro Leu Ser Phe Ser Pro Pro Gly Leu
         115                 120                 125            
 Arg Arg Thr Arg
     130        



      <210> 1193
      <211> 1003
      <212> PRT
      <213> Homo sapiens


      <400> 1193
 Met Cys Val Arg Ala Lys Glu Arg Lys Asn Gly Ser Ala Gln Thr His
   1               5                  10                  15    
 Arg Pro Ala Thr Met Val Gln Ala Ile Phe Ser Gly Asp Pro Glu Glu
              20                  25                  30        
 Ile Arg Met Leu Ile His Lys Thr Glu Asp Val Asn Thr Leu Asp Ser
          35                  40                  45            
 Glu Lys Arg Thr Pro Leu His Val Ala Ala Phe Leu Gly Asp Ala Glu
      50                  55                  60                
 Ile Ile Glu Leu Leu Ile Leu Ser Gly Ala Arg Val Asn Ala Lys Asp
  65                  70                  75                  80
 Asn Met Trp Leu Thr Pro Leu His Arg Ala Val Ala Ser Arg Ser Glu
                  85                  90                  95    
 Glu Ala Val Gln Val Leu Ile Lys His Ser Ala Asp Val Asn Ala Arg
             100                 105                 110        
 Asp Lys Asn Trp Gln Thr Pro Leu His Val Ala Ala Ala Asn Lys Ala
         115                 120                 125            
 Val Lys Cys Ala Glu Val Ile Ile Pro Leu Leu Ser Ser Val Asn Val
     130                 135                 140                
 Ser Asp Arg Gly Gly Arg Thr Ala Leu His His Ala Ala Leu Asn Gly
 145                 150                 155                 160
 His Val Glu Met Val Asn Leu Leu Leu Ala Lys Gly Ala Asn Ile Asn
                 165                 170                 175    
 Ala Phe Asp Lys Lys Asp Arg Arg Ala Leu His Trp Ala Ala Tyr Met
             180                 185                 190        
 Gly His Leu Asp Val Val Ala Leu Leu Ile Asn His Gly Ala Glu Val
         195                 200                 205            
 Thr Cys Lys Asp Lys Lys Gly Tyr Thr Pro Leu His Ala Ala Ala Ser
     210                 215                 220                
 Asn Gly Gln Ile Asn Val Val Lys His Leu Leu Asn Leu Gly Val Glu
 225                 230                 235                 240
 Ile Asp Glu Ile Asn Val Tyr Gly Asn Thr Ala Leu His Ile Ala Cys
                 245                 250                 255    
 Tyr Asn Gly Gln Asp Ala Val Val Asn Glu Leu Ile Asp Tyr Gly Ala
             260                 265                 270        
 Asn Val Asn Gln Pro Asn Asn Asn Gly Phe Thr Pro Leu His Phe Ala
         275                 280                 285            
 Ala Ala Ser Thr His Gly Ala Leu Cys Leu Glu Leu Leu Val Asn Asn
     290                 295                 300                
 Gly Ala Asp Val Asn Ile Gln Ser Lys Asp Gly Lys Ser Pro Leu His
 305                 310                 315                 320
 Met Thr Ala Val His Gly Arg Phe Thr Arg Ser Gln Thr Leu Ile Gln
                 325                 330                 335    
 Asn Gly Gly Glu Ile Asp Cys Val Asp Lys Asp Gly Asn Thr Pro Leu
             340                 345                 350        
 His Val Ala Ala Arg Tyr Gly His Glu Leu Leu Ile Asn Thr Leu Ile
         355                 360                 365            
 Thr Ser Gly Ala Asp Thr Ala Lys Cys Gly Ile His Ser Met Phe Pro
     370                 375                 380                
 Leu His Leu Ala Ala Leu Asn Ala His Ser Asp Cys Cys Arg Lys Leu
 385                 390                 395                 400
 Leu Ser Ser Gly Gln Lys Tyr Ser Ile Val Ser Leu Phe Ser Asn Glu
                 405                 410                 415    
 His Val Leu Ser Ala Gly Phe Glu Ile Asp Thr Pro Asp Lys Phe Gly
             420                 425                 430        
 Arg Thr Cys Leu His Ala Ala Ala Ala Gly Gly Asn Val Glu Cys Ile
         435                 440                 445            
 Lys Leu Leu Gln Ser Ser Gly Ala Asp Phe His Lys Lys Asp Lys Cys
     450                 455                 460                
 Gly Arg Thr Pro Leu His Tyr Ala Ala Ala Asn Cys His Phe His Cys
 465                 470                 475                 480
 Ile Glu Thr Leu Val Thr Thr Gly Ala Asn Val Asn Glu Thr Asp Asp
                 485                 490                 495    
 Trp Gly Arg Thr Ala Leu His Tyr Ala Ala Ala Ser Asp Met Asp Arg
             500                 505                 510        
 Asn Lys Thr Ile Leu Gly Asn Ala His Asp Asn Ser Glu Glu Leu Glu
         515                 520                 525            
 Arg Ala Arg Glu Leu Lys Glu Lys Glu Ala Thr Leu Cys Leu Glu Phe
     530                 535                 540                
 Leu Leu Gln Asn Asp Ala Asn Pro Ser Ile Arg Asp Lys Glu Gly Tyr
 545                 550                 555                 560
 Asn Ser Ile His Tyr Ala Ala Ala Tyr Gly His Arg Gln Cys Leu Glu
                 565                 570                 575    
 Leu Leu Leu Glu Arg Thr Asn Ser Gly Phe Glu Glu Ser Asp Ser Gly
             580                 585                 590        
 Ala Thr Lys Ser Pro Leu His Leu Ala Ala Tyr Asn Gly His His Gln
         595                 600                 605            
 Ala Leu Glu Val Leu Leu Gln Ser Leu Val Asp Leu Asp Ile Arg Asp
     610                 615                 620                
 Glu Lys Gly Arg Thr Ala Leu Asp Leu Ala Ala Phe Lys Gly His Thr
 625                 630                 635                 640
 Glu Cys Val Glu Ala Leu Ile Asn Gln Gly Ala Ser Ile Phe Val Lys
                 645                 650                 655    
 Asp Asn Val Thr Lys Arg Thr Pro Leu His Ala Ser Val Ile Asn Gly
             660                 665                 670        
 His Thr Leu Cys Leu Arg Leu Leu Leu Glu Ile Ala Asp Asn Pro Glu
         675                 680                 685            
 Ala Val Asp Val Lys Asp Ala Lys Gly Gln Thr Pro Leu Met Leu Ala
     690                 695                 700                
 Val Ala Tyr Gly His Ile Asp Ala Val Ser Leu Leu Leu Glu Lys Glu
 705                 710                 715                 720
 Ala Asn Val Asp Thr Val Asp Ile Leu Gly Cys Thr Ala Leu His Arg
                 725                 730                 735    
 Gly Ile Met Thr Gly His Glu Glu Cys Val Gln Met Leu Leu Glu Gln
             740                 745                 750        
 Glu Val Ser Ile Leu Cys Lys Asp Ser Arg Gly Arg Thr Pro Leu His
         755                 760                 765            
 Tyr Ala Ala Ala Arg Gly His Ala Thr Trp Leu Ser Glu Leu Leu Gln
     770                 775                 780                
 Met Ala Leu Ser Glu Glu Asp Cys Cys Phe Lys Asp Asn Gln Gly Tyr
 785                 790                 795                 800
 Thr Pro Leu His Trp Ala Cys Tyr Asn Gly Asn Glu Asn Cys Ile Glu
                 805                 810                 815    
 Val Leu Leu Glu Gln Lys Cys Phe Arg Lys Phe Ile Gly Asn Pro Phe
             820                 825                 830        
 Thr Pro Leu His Cys Ala Ile Ile Asn Asp His Gly Asn Cys Ala Ser
         835                 840                 845            
 Leu Leu Leu Gly Ala Ile Asp Ser Ser Ile Val Ser Cys Arg Asp Asp
     850                 855                 860                
 Lys Gly Arg Thr Pro Leu His Ala Ala Ala Phe Ala Asp His Val Glu
 865                 870                 875                 880
 Cys Leu Gln Leu Leu Leu Arg His Ser Ala Pro Val Asn Ala Val Asp
                 885                 890                 895    
 Asn Ser Gly Lys Thr Ala Leu Met Met Ala Ala Glu Asn Gly Gln Ala
             900                 905                 910        
 Gly Ala Val Asp Ile Leu Val Asn Ser Ala Gln Ala Asp Leu Thr Val
         915                 920                 925            
 Lys Asp Lys Asp Leu Asn Thr Pro Leu His Leu Ala Cys Ser Lys Gly
     930                 935                 940                
 His Glu Lys Cys Ala Leu Leu Ile Leu Asp Lys Ile Gln Asp Glu Ser
 945                 950                 955                 960
 Leu Ile Asn Glu Lys Asn Asn Ala Leu Gln Thr Pro Leu His Val Ala
                 965                 970                 975    
 Ala Arg Asn Gly Leu Lys Val Val Val Glu Glu Leu Leu Ala Lys Gly
             980                 985                 990        
 Ala Cys Val Leu Ala Val Asp Glu Asn Gly Cys
         995                1000            



      <210> 1194
      <211> 426
      <212> PRT
      <213> Homo sapiens


      <400> 1194
 Met Ala Ala Pro Arg Ala Gly Arg Gly Ala Gly Trp Ser Leu Arg Ala
   1               5                  10                  15    
 Trp Arg Ala Leu Gly Gly Ile Arg Trp Gly Arg Arg Pro Arg Leu Thr
              20                  25                  30        
 Pro Asp Leu Arg Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala
          35                  40                  45            
 Arg Val Thr Tyr Gly Thr Pro Ser Leu Trp Ala Arg Leu Ser Val Gly
      50                  55                  60                
 Val Thr Glu Pro Arg Ala Cys Leu Thr Ser Gly Thr Pro Gly Pro Arg
  65                  70                  75                  80
 Ala Gln Leu Thr Ala Val Thr Pro Asp Thr Arg Thr Arg Glu Ala Ser
                  85                  90                  95    
 Glu Asn Ser Gly Thr Arg Ser Arg Ala Trp Leu Ala Val Ala Leu Gly
             100                 105                 110        
 Ala Gly Gly Ala Val Leu Leu Leu Leu Trp Gly Gly Gly Arg Gly Pro
         115                 120                 125            
 Pro Ala Val Leu Ala Ala Val Pro Ser Pro Pro Pro Ala Ser Pro Arg
     130                 135                 140                
 Ser Gln Tyr Asn Phe Ile Ala Asp Val Val Glu Lys Thr Ala Pro Ala
 145                 150                 155                 160
 Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Phe Leu Gly Arg Glu
                 165                 170                 175    
 Val Pro Ile Ser Asn Gly Ser Gly Phe Val Val Ala Ala Asp Gly Leu
             180                 185                 190        
 Ile Val Thr Asn Ala His Val Val Ala Asp Arg Arg Arg Val Arg Val
         195                 200                 205            
 Arg Leu Leu Ser Gly Asp Thr Tyr Glu Ala Val Val Thr Ala Val Asp
     210                 215                 220                
 Pro Val Ala Asp Ile Ala Thr Leu Arg Ile Gln Thr Lys Glu Pro Leu
 225                 230                 235                 240
 Pro Thr Leu Pro Leu Gly Arg Ser Ala Asp Val Arg Gln Gly Glu Phe
                 245                 250                 255    
 Val Val Ala Met Gly Ser Pro Phe Ala Leu Gln Asn Thr Ile Thr Ser
             260                 265                 270        
 Gly Ile Val Ser Ser Ala Gln Arg Pro Ala Arg Asp Leu Gly Leu Pro
         275                 280                 285            
 Gln Thr Asn Val Glu Tyr Ile Gln Thr Asp Ala Ala Ile Asp Phe Gly
     290                 295                 300                
 Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Val
 305                 310                 315                 320
 Asn Thr Met Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp
                 325                 330                 335    
 Arg Leu Arg Glu Phe Leu His Arg Gly Glu Lys Lys Asn Ser Ser Ser
             340                 345                 350        
 Gly Ile Ser Gly Ser Gln Arg Arg Tyr Ile Gly Val Met Met Leu Thr
         355                 360                 365            
 Leu Ser Pro Arg Ala Gly Leu Arg Pro Gly Asp Val Ile Leu Ala Ile
     370                 375                 380                
 Gly Glu Gln Met Val Gln Asn Ala Glu Asp Val Tyr Glu Ala Val Arg
 385                 390                 395                 400
 Thr Gln Ser Gln Leu Ala Val Gln Ile Arg Arg Gly Arg Glu Thr Leu
                 405                 410                 415    
 Thr Leu Tyr Val Thr Pro Glu Val Thr Glu
             420                 425    



      <210> 1195
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 1195
 Met Phe Gly Trp Asn Met Lys Leu Thr Ser Glu Tyr His Arg Asn Val
   1               5                  10                  15    
 Thr Phe Leu Ser Cys Gln Phe Val Ser Val Met Arg Met Asp Tyr Met
              20                  25                  30        
 Val Tyr Phe Ser Phe Leu Thr Trp Ile Phe Ile Pro Leu Val Val Met
          35                  40                  45            
 Cys Ala Ile Tyr Leu Asp Ile Phe Tyr Ile Ile Arg Asn Lys Leu Ser
      50                  55                  60                
 Leu Asn Leu Ser Asn Ser Lys Glu Thr Gly Ala Phe Tyr Gly Arg Glu
  65                  70                  75                  80
 Phe Lys Thr Ala Lys Ser Leu Phe Leu Val Leu Phe Leu Phe Ala Leu
                  85                  90                  95    
 Ser Trp Leu Pro Leu Ser Ile Ile Asn Cys Ile Ile Tyr Phe Asn Gly
             100                 105                 110        
 Glu Val Pro Gln Leu Val Leu Tyr Met Gly Ile Leu Leu Ser His Ala
         115                 120                 125            
 Asn Ser Met Met Asn Pro Ile Val Tyr Ala Tyr Lys Ile Lys Lys Phe
     130                 135                 140                
 Lys Glu Thr Tyr Leu Leu Ile Leu Lys Ala Cys Val Val Cys His Pro
 145                 150                 155                 160
 Ser Asp Ser Leu Asp Thr Ser Ile Glu Lys Asn Ser Glu
                 165                 170            



      <210> 1196
      <211> 291
      <212> PRT
      <213> Homo sapiens


      <400> 1196
 Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys Arg
   1               5                  10                  15    
 Arg Ser Pro Gly Ile Thr Cys Cys Val Leu Leu Leu Leu Asn Cys Ser
              20                  25                  30        
 Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Thr Gly Ser Val Ala
          35                  40                  45            
 Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Thr Asp
      50                  55                  60                
 Asn Pro Cys Ile Met Cys Val Cys Leu Asn Lys Glu Val Thr Cys Lys
  65                  70                  75                  80
 Arg Glu Lys Cys Pro Val Leu Ser Arg Asp Cys Ala Leu Ala Ile Lys
                  85                  90                  95    
 Gln Arg Gly Ala Cys Cys Glu Gln Cys Lys Gly Cys Thr Tyr Glu Gly
             100                 105                 110        
 Asn Thr Tyr Asn Ser Ser Phe Lys Trp Gln Ser Pro Ala Glu Pro Cys
         115                 120                 125            
 Val Leu Arg Gln Cys Gln Glu Gly Val Val Thr Glu Ser Gly Val Arg
     130                 135                 140                
 Cys Val Val His Cys Lys Asn Pro Leu Glu His Leu Gly Met Cys Cys
 145                 150                 155                 160
 Pro Thr Cys Pro Gly Cys Val Phe Glu Gly Val Gln Tyr Gln Glu Gly
                 165                 170                 175    
 Glu Glu Phe Gln Pro Glu Gly Ser Lys Cys Thr Lys Cys Ser Cys Thr
             180                 185                 190        
 Val Arg Gly Lys Cys Leu Thr Ser Leu Leu Gly Ala Ala Ser Phe Glu
         195                 200                 205            
 Val Met Phe Met Thr Met Asp Pro His Phe Cys Thr Ile Thr Ala Gln
     210                 215                 220                
 Leu Val Pro Ala Gly Thr Leu Leu Trp Phe Ala Arg Gly Ser Ala Pro
 225                 230                 235                 240
 Thr Leu Val Ala Val Thr Lys Ala Arg Arg Ala Val Val Lys Ser Ala
                 245                 250                 255    
 Ser Tyr Glu Cys Pro Gln Lys Thr Ser Lys Tyr Ala Asn Leu Ala Thr
             260                 265                 270        
 Arg Phe Ser Arg Met Glu Arg Cys Gly Pro Leu Ser Ile Val Pro Ser
         275                 280                 285            
 Val Leu Val
     290    



      <210> 1197
      <211> 321
      <212> PRT
      <213> Homo sapiens


      <400> 1197
 Met Glu Thr Ile Thr Cys Asn Gly Ser Gly Asp Ser Ser Thr Thr Phe
   1               5                  10                  15    
 Tyr Leu Met Gly Ile Pro Ser Leu Pro Lys Ser Leu Phe Leu Pro Ile
              20                  25                  30        
 Phe Phe Val Phe Leu Leu Leu Tyr Val Leu Ile Leu Met Gly Asn Thr
          35                  40                  45            
 Phe Ile Leu Val Ala Val Val Ala Lys Pro Ser Leu His Lys Pro Met
      50                  55                  60                
 Tyr Phe Phe Leu Ile Asn Leu Ser Thr Leu Asp Ile Leu Val Thr Thr
  65                  70                  75                  80
 Thr Thr Val Pro Lys Met Leu Ser Leu Phe Leu Phe Gly Asp Ser Phe
                  85                  90                  95    
 Leu Ser Phe Pro Ala Cys Phe Leu Gln Met Tyr Leu Phe His Ser Phe
             100                 105                 110        
 Ser Cys Ser Glu Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg Tyr
         115                 120                 125            
 Val Ala Ile Cys Arg Pro Leu His Tyr Pro Val Leu Met Thr Pro Gln
     130                 135                 140                
 Thr Asn Thr Val Leu Thr Thr Ser Ala Trp Leu Thr Ala Leu Leu Leu
 145                 150                 155                 160
 Pro Ile Pro Ala Val Val Gln Thr Ser Gln Met Ala Phe Asp Ile Ile
                 165                 170                 175    
 Val His Ile Tyr His Cys Phe Cys Asp His Leu Ala Val Val Gln Ala
             180                 185                 190        
 Ser Cys Ser Asp Thr Ser Pro Gln Thr Phe Met Gly Phe Cys Ile Ala
         195                 200                 205            
 Met Val Val Ser Phe Leu Pro Leu Leu Leu Val Leu Leu Ser Tyr Ala
     210                 215                 220                
 His Ile Leu Thr Ser Val Leu Cys Ile Asn Cys Gln Glu Gly Arg Ser
 225                 230                 235                 240
 Lys Ala Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Gly Thr Tyr
                 245                 250                 255    
 Tyr Ser Ser Ile Ala Ile Ala Tyr Val Ala Tyr Arg Ala Asp Leu Pro
             260                 265                 270        
 Leu Asp Phe His Val Met Gly Asn Val Val Tyr Ala Ile Leu Thr Pro
         275                 280                 285            
 Val Leu Asn Pro Val Ile Tyr Lys Leu Arg Asn Lys Asp Val Lys Ala
     290                 295                 300                
 Ala Ile Thr Lys Ile Ala Cys Pro Gln Glu Pro Lys Asn Ala Arg Lys
 305                 310                 315                 320
 Pro
    



      <210> 1198
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 1198
 Met Arg Tyr Gly Ser Val Cys Ser Gly Ala Ala Ala Met Pro Ile Glu
   1               5                  10                  15    
 Glu Pro Ala Leu Arg Ser Trp Gln Arg Pro Phe Leu Lys Trp Ala Gly
              20                  25                  30        
 Gly Lys Tyr Ser Leu Leu Pro Glu Leu Asp Arg Leu Ile Pro Ala Gly
          35                  40                  45            
 Lys Arg Leu Ile Glu Pro Phe Val Gly Gly Gly Ser Val Phe Leu Asn
      50                  55                  60                
 Ser Asp Lys His Glu Arg Phe Leu Leu Ala Asp Val Ser Ala Asp Leu
  65                  70                  75                  80
 Ile Asn Leu Tyr Gln Met Leu Ala Val Val Pro Asp Ser Val Ile Tyr
                  85                  90                  95    
 Glu Ala Met Lys Ala Phe Arg His Leu Asn Asp Ala Glu Asn Tyr Thr
             100                 105                 110        
 Leu Ile Arg Glu Ala Phe Asn Ala Gln Arg Leu Asp Ala Val Glu Arg
         115                 120                 125            
 Ala Ala Ala Phe Leu Tyr Leu Asn Arg His Cys Phe Asn Gly Leu Ile
     130                 135                 140                
 Arg Tyr Asn Leu Asp Gly Phe Phe
 145                 150        



      <210> 1199
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 1199
 Met Met Ser Phe Leu Leu Gly Ala Ile Leu Thr Leu Leu Trp Ala Pro
   1               5                  10                  15    
 Thr Ala Gln Ala Glu Val Leu Leu Gln Pro Asp Phe Asn Ala Glu Lys
              20                  25                  30        
 Phe Ser Gly Leu Trp Tyr Val Val Ser Met Ala Ser Asp Cys Arg Val
          35                  40                  45            
 Phe Leu Gly Lys Lys Asp His Leu Ser Met Ser Thr Arg Ala Ile Arg
      50                  55                  60                
 Pro Thr Glu Glu Gly Gly Leu His Val His Met Glu Phe Pro Gly Ala
  65                  70                  75                  80
 Asp Gly Cys Asn Gln Val Asp Ala Glu Tyr Leu Lys Val Gly Ser Glu
                  85                  90                  95    
 Gly His Phe Arg Val Pro Ala Leu Gly Tyr Leu Asp Val Arg Ile Val
             100                 105                 110        
 Asp Thr Asp Tyr Ser Ser Phe Ala Val Leu Tyr Ile Tyr Lys Glu Leu
         115                 120                 125            
 Glu Gly Ala Leu Ser Thr Met Val Gln Leu Tyr Ser Arg Thr Gln Asp
     130                 135                 140                
 Val Ser Pro Gln Ala Leu Lys Ala Phe Gln Asp Phe Tyr Pro Thr Leu
 145                 150                 155                 160
 Gly Leu Pro Glu Asp Met Met Val Met Leu Pro Gln Ser Asp Ala Cys
                 165                 170                 175    
 Asn Pro Glu Ser Lys Glu Ala Pro
             180                



      <210> 1200
      <211> 477
      <212> PRT
      <213> Homo sapiens


      <400> 1200
 Met Leu Gly Val Arg Cys Leu Leu Arg Ser Val Arg Phe Cys Ser Ser
   1               5                  10                  15    
 Ala Pro Phe Pro Lys His Lys Pro Ser Ala Lys Leu Ser Val Arg Asp
              20                  25                  30        
 Ala Leu Gly Ala Gln Asn Ala Ser Gly Glu Arg Ile Lys Ile Gln Gly
          35                  40                  45            
 Trp Ile Arg Ser Val Arg Ser Gln Lys Glu Val Leu Phe Leu His Val
      50                  55                  60                
 Asn Asp Gly Ser Ser Leu Glu Ser Leu Gln Val Val Ala Asp Ser Gly
  65                  70                  75                  80
 Leu Asp Ser Arg Glu Leu Thr Phe Gly Ser Ser Val Glu Val Gln Gly
                  85                  90                  95    
 Gln Leu Ile Lys Ser Pro Ser Lys Arg Gln Asn Val Glu Leu Lys Ala
             100                 105                 110        
 Glu Lys Ile Lys Val Ile Gly Asn Cys Asp Ala Lys Asp Phe Pro Ile
         115                 120                 125            
 Lys Tyr Lys Glu Arg His Pro Leu Glu Tyr Leu Arg Gln Tyr Pro His
     130                 135                 140                
 Phe Arg Cys Arg Thr Asn Val Leu Gly Ser Ile Leu Arg Ile Arg Ser
 145                 150                 155                 160
 Glu Ala Thr Ala Ala Ile His Ser Phe Phe Lys Asp Ser Gly Phe Val
                 165                 170                 175    
 His Ile His Thr Pro Ile Ile Thr Ser Asn Asp Ser Glu Gly Ala Gly
             180                 185                 190        
 Glu Leu Phe Gln Leu Glu Pro Ser Gly Lys Leu Lys Val Pro Glu Glu
         195                 200                 205            
 Asn Phe Phe Asn Val Pro Ala Phe Leu Thr Val Ser Gly Gln Leu His
     210                 215                 220                
 Leu Glu Val Met Ser Gly Ala Phe Thr Gln Val Phe Thr Phe Gly Pro
 225                 230                 235                 240
 Thr Phe Arg Ala Glu Asn Ser Gln Ser Arg Arg His Leu Ala Glu Phe
                 245                 250                 255    
 Tyr Met Ile Glu Ala Glu Ile Ser Phe Val Asp Ser Leu Gln Asp Leu
             260                 265                 270        
 Met Gln Val Ile Glu Glu Leu Phe Lys Ala Thr Thr Met Met Val Leu
         275                 280                 285            
 Ser Lys Cys Pro Glu Asp Val Glu Leu Cys His Lys Phe Ile Ala Pro
     290                 295                 300                
 Gly Gln Lys Asp Arg Leu Glu His Met Leu Lys Asn Asn Phe Leu Ile
 305                 310                 315                 320
 Ile Ser Tyr Thr Glu Ala Val Glu Ile Leu Lys Gln Ala Ser Gln Asn
                 325                 330                 335    
 Phe Thr Phe Thr Pro Glu Trp Gly Ala Asp Leu Arg Thr Glu His Glu
             340                 345                 350        
 Lys Tyr Leu Val Lys His Cys Gly Asn Ile Pro Val Phe Val Ile Asn
         355                 360                 365            
 Tyr Pro Leu Thr Leu Lys Pro Phe Tyr Met Arg Asp Asn Glu Asp Gly
     370                 375                 380                
 Pro Gln His Thr Val Ala Ala Val Asp Leu Leu Val Pro Gly Val Gly
 385                 390                 395                 400
 Glu Leu Phe Gly Gly Gly Leu Arg Glu Glu Arg Tyr His Phe Leu Glu
                 405                 410                 415    
 Glu Arg Leu Ala Arg Ser Gly Leu Thr Glu Val Tyr Gln Trp Tyr Leu
             420                 425                 430        
 Asp Leu Arg Arg Phe Gly Ser Val Pro His Gly Gly Phe Gly Met Gly
         435                 440                 445            
 Phe Glu Arg Tyr Leu Gln Cys Ile Leu Gly Val Asp Asn Ile Lys Asp
     450                 455                 460                
 Val Ile Pro Phe Pro Arg Phe Pro His Ser Cys Leu Leu
 465                 470                 475        



      <210> 1201
      <211> 699
      <212> PRT
      <213> Homo sapiens


      <400> 1201
 Met Leu Lys Leu Ser Gly Glu Gly Leu Arg Asp Ser Tyr His Ser Arg
   1               5                  10                  15    
 Arg Asp Gln Ile Ala Leu Lys Asn Leu Gln Ser Asp Val Thr Glu Ala
              20                  25                  30        
 Lys Ser Asp Phe Thr Lys Glu Thr Leu Ala Ser Gln Asn Thr Lys Met
          35                  40                  45            
 Ile Ser Ser Ile Val Ile Ser Gln Met Ile Asp Glu Asn Lys Ser Arg
      50                  55                  60                
 Glu Asn Arg Ala Ser Leu Pro Leu Pro Cys Ala Ile Ala Gln Ser Arg
  65                  70                  75                  80
 Ala His His Ala Lys Gln Ser Leu Ala Asn Arg Ser Gly Val Asn Ile
                  85                  90                  95    
 His Arg Ala Phe Ala Leu Leu Pro Gly Arg Leu Gly Ile Pro Ala Pro
             100                 105                 110        
 Ser Asp Glu Arg Gly Pro Glu Ala Glu Leu Pro Pro Lys Glu Glu Arg
         115                 120                 125            
 Pro Cys Gly Gly Pro Arg Arg Gly Phe Ala Ser Ile Thr Ile Thr Ala
     130                 135                 140                
 Arg Arg Val Gly Pro Pro Ala Arg Ala Leu Val Trp Gly Thr Ala Gly
 145                 150                 155                 160
 Asp Ser Leu Cys Pro Lys Cys Arg Ala Glu Asp Thr Leu Phe Gln Ala
                 165                 170                 175    
 Pro Pro Ala Leu Ala Asn Gly Ala His Pro Gly Arg His Gln Arg Ser
             180                 185                 190        
 Phe Ala Cys Thr Glu Phe Ser Arg Asn Ser Ser Val Val Arg Leu Lys
         195                 200                 205            
 Val Pro Glu Ala His Thr Gly Leu Cys Glu Arg Arg Lys Tyr Trp Val
     210                 215                 220                
 Thr His Ala Asp Asp Lys Glu Thr Ser Phe Ser Pro Asp Thr Pro Leu
 225                 230                 235                 240
 Ser Gly Lys Ser Pro Leu Val Phe Ser Ser Cys Val His Leu Arg Val
                 245                 250                 255    
 Ser Gln Gln Cys Pro Asp Ser Ile Tyr Tyr Val Asp Lys Ser Leu Ser
             260                 265                 270        
 Val Pro Ile Glu Pro Pro Gln Ile Ala Ser Pro Lys Met His Arg Ser
         275                 280                 285            
 Val Leu Ser Leu Asn Leu Asn Cys Ser Ser His Arg Leu Thr Ala Asp
     290                 295                 300                
 Gly Val Asp Gly Leu Val Asn Arg Glu Pro Ile Ser Glu Ala Leu Lys
 305                 310                 315                 320
 Gln Glu Leu Leu Glu Gly Asp Gln Asp Leu Val Gly Gln Arg Trp Asn
                 325                 330                 335    
 Pro Gly Leu Gln Glu Ser His Leu Lys Glu Thr Pro Ser Leu Arg Arg
             340                 345                 350        
 Val His Leu Gly Thr Gly Ala Cys Pro Trp Ser Gly Ser Phe Pro Leu
         355                 360                 365            
 Glu Asn Thr Glu Leu Ala Asn Val Gly Ala Asn Gln Val Thr Val Arg
     370                 375                 380                
 Lys Gly Glu Lys Asp His Thr Thr His Cys His Ala Ser Asp His Ala
 385                 390                 395                 400
 Asn Gln Leu Ser Ile His Ile Pro Gly Trp Ser Tyr Arg Ala Val His
                 405                 410                 415    
 Thr Lys Val Phe Ser Gly Ser Ser Lys Arg Gln Gln Gly Glu Val Cys
             420                 425                 430        
 Met Thr Val Ser Ala Pro Pro Val Glu Gln Lys Pro Thr Arg His Phe
         435                 440                 445            
 Leu Pro Ile Gly Asp Ser Ser Pro Ser Asp Asp Cys Leu Ser Arg Asp
     450                 455                 460                
 Leu Ser Glu Pro Thr Glu Arg Arg His Gln Ser Phe Leu Lys Pro Arg
 465                 470                 475                 480
 Ile Leu Phe Pro Gly Phe Leu Cys Pro Leu Gln Asp Val Cys Ala Ser
                 485                 490                 495    
 Leu Gln Glu Asp Asn Gly Val Gln Ile Glu Ser Lys Phe Pro Lys Gly
             500                 505                 510        
 Asp Tyr Thr Cys Cys Asp Leu Val Val Lys Ile Lys Glu Cys Lys Lys
         515                 520                 525            
 Ser Glu Asp Pro Thr Thr Pro Glu Pro Ser Pro Ala Ala Pro Ser Pro
     530                 535                 540                
 Ala Pro Arg Asp Gly Ala Gly Ser Pro Gly Leu Ser Glu Asp Cys Ser
 545                 550                 555                 560
 Glu Ser Gln Gln Thr Pro Ala Arg Ser Leu Thr Leu Gln Glu Ala Leu
                 565                 570                 575    
 Glu Val Arg Lys Pro Gln Phe Ile Ser Arg Ser Gln Glu Arg Leu Lys
             580                 585                 590        
 Lys Leu Glu His Met Val Gln Gln Arg Lys Ala Gln Arg Lys Glu Asp
         595                 600                 605            
 Leu Arg Gln Lys Gln Ser Leu Leu Pro Ile Arg Thr Ser Lys Lys Gln
     610                 615                 620                
 Phe Thr Ile Pro His Pro Leu Ser Asp Asn Leu Phe Lys Pro Lys Glu
 625                 630                 635                 640
 Arg Cys Ile Ser Glu Lys Glu Met His Met Arg Ser Lys Arg Ile Tyr
                 645                 650                 655    
 Asp Asn Leu Pro Glu Val Lys Lys Lys Lys Glu Glu Gln Lys Lys Arg
             660                 665                 670        
 Val Ile Leu Gln Ser Asn Arg Leu Arg Ala Glu Val Phe Lys Lys Gln
         675                 680                 685            
 Leu Leu Asp Gln Leu Leu Gln Arg Asn Ala Val
     690                 695                



      <210> 1202
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 1202
 Met Pro Phe Ser Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala Phe
   1               5                  10                  15    
 Gly Gly Gln Ser Leu Lys Phe Gly Lys Gly Arg Gln Ala His Arg Cys
              20                  25                  30        
 Cys Cys Val Ala Asp Arg Thr Gly His Ser Ile Leu His Thr Ser Tyr
          35                  40                  45            
 Gly Arg Ser Leu Arg Tyr Asp Thr Ser Cys Phe Val Glu Tyr Phe Ala
      50                  55                  60                
 Leu Asp Leu Leu Ile Glu Asn Arg Glu Cys Arg Gly Val Ile Ala Leu
  65                  70                  75                  80
 Cys Ile Gln Asp Gly Ser Ile His Arg Ile Arg Ala Lys Asn Thr Ile
                  85                  90                  95    
 Val Ala Thr Gly Leu Leu Ala Gln Leu Leu Glu Leu His Val Cys Pro
             100                 105                 110        
 His Gln His Gln Arg Arg His Gly His Asp His Gln Gly Arg Pro Ser
         115                 120                 125            
 Leu Pro Gly Pro Arg Val Cys Ser Val Pro Pro His Arg His Ile Trp
     130                 135                 140                
 Cys Trp Leu Ser His Tyr Gly Arg Met Ser Trp Arg Gly Arg His Ser
 145                 150                 155                 160
 His
    



      <210> 1203
      <211> 481
      <212> PRT
      <213> Homo sapiens


      <400> 1203
 Met Pro Gln Thr Ser Val Val Phe Ser Ser Ile Leu Gly Pro Ser Cys
   1               5                  10                  15    
 Ser Gly Gln Val Gln Pro Gly Met Gly Glu Arg Gly Gly Gly Ala Gly
              20                  25                  30        
 Gly Gly Ser Gly Asp Leu Ile Phe Gln Asp Gly His Leu Ile Ser Gly
          35                  40                  45            
 Ser Leu Glu Ala Leu Met Glu His Leu Val Pro Thr Val Asp Tyr Tyr
      50                  55                  60                
 Pro Asp Arg Thr Tyr Ile Phe Thr Phe Leu Leu Ser Ser Arg Val Phe
  65                  70                  75                  80
 Met Pro Pro His Asp Leu Leu Ala Arg Val Gly Gln Ile Cys Val Glu
                  85                  90                  95    
 Gln Lys Gln Gln Leu Glu Ala Gly Pro Glu Lys Ala Lys Leu Lys Ser
             100                 105                 110        
 Phe Ser Ala Lys Ile Val Gln Leu Leu Lys Glu Trp Thr Glu Ala Phe
         115                 120                 125            
 Pro Tyr Asp Phe Gln Asp Glu Lys Ala Met Ala Glu Leu Lys Ala Ile
     130                 135                 140                
 Thr His Arg Val Thr Gln Cys Asp Glu Glu Asn Gly Thr Val Lys Lys
 145                 150                 155                 160
 Ala Ile Ala Gln Met Thr Gln Ser Leu Leu Leu Ser Leu Ala Ala Arg
                 165                 170                 175    
 Ser Gln Leu Gln Glu Leu Arg Glu Lys Leu Arg Pro Pro Ala Val Asp
             180                 185                 190        
 Lys Gly Pro Ile Leu Lys Thr Lys Pro Pro Ala Ala Gln Lys Asp Ile
         195                 200                 205            
 Leu Gly Val Cys Cys Asp Pro Leu Val Leu Ala Gln Gln Leu Thr His
     210                 215                 220                
 Ile Glu Leu Asp Arg Val Ser Ser Ile Tyr Pro Glu Asp Leu Met Gln
 225                 230                 235                 240
 Ile Val Ser His Met Asp Ser Leu Asp Asn His Arg Cys Arg Gly Asp
                 245                 250                 255    
 Leu Thr Lys Thr Tyr Ser Leu Glu Ala Tyr Asp Asn Trp Phe Asn Cys
             260                 265                 270        
 Leu Ser Met Leu Val Ala Thr Glu Val Cys Arg Val Val Lys Lys Lys
         275                 280                 285            
 His Arg Thr Arg Met Leu Glu Phe Phe Ile Asp Val Ala Arg Glu Cys
     290                 295                 300                
 Phe Asn Ile Gly Asn Phe Asn Ser Met Met Ala Ile Ile Ser Gly Met
 305                 310                 315                 320
 Asn Leu Ser Pro Val Ala Arg Leu Lys Lys Thr Trp Ser Lys Val Lys
                 325                 330                 335    
 Thr Ala Lys Phe Asp Val Leu Glu His His Met Asp Pro Ser Ser Asn
             340                 345                 350        
 Phe Cys Asn Tyr Arg Thr Ala Leu Gln Gly Ala Thr Gln Arg Ser Gln
         355                 360                 365            
 Met Ala Asn Ser Ser Arg Glu Lys Ile Val Ile Pro Val Phe Asn Leu
     370                 375                 380                
 Phe Val Lys Asp Ile Tyr Phe Leu His Lys Ile His Thr Asn His Leu
 385                 390                 395                 400
 Pro Asn Gly His Ile Asn Phe Lys Lys Phe Trp Glu Ile Ser Arg Gln
                 405                 410                 415    
 Ile His Glu Phe Met Thr Trp Thr Gln Val Glu Cys Pro Phe Glu Lys
             420                 425                 430        
 Asp Lys Lys Ile Gln Ser Tyr Leu Leu Thr Ala Pro Ile Tyr Ser Glu
         435                 440                 445            
 Glu Ala Leu Phe Val Ala Ser Phe Glu Ser Glu Gly Pro Glu Asn His
     450                 455                 460                
 Met Glu Lys Asp Ser Trp Lys Thr Leu Arg Thr Thr Leu Leu Asn Arg
 465                 470                 475                 480
 Ala
    



      <210> 1204
      <211> 339
      <212> PRT
      <213> Homo sapiens


      <400> 1204
 Met Glu Ser Lys Val Ser Glu Gly Gly Leu Asn Val Thr Leu Thr Ile
   1               5                  10                  15    
 Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys
              20                  25                  30        
 Gly Glu Thr Val Lys Lys Met Arg Glu Glu Ser Gly Ala Arg Ile Asn
          35                  40                  45            
 Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Val Thr Ile Thr Gly Pro
      50                  55                  60                
 Thr Asp Ala Ile Phe Lys Ala Phe Ala Met Ile Ala Tyr Lys Phe Glu
  65                  70                  75                  80
 Glu Asp Ile Ile Asn Ser Met Ser Asn Ser Pro Ala Thr Ser Lys Pro
                  85                  90                  95    
 Pro Val Thr Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu
             100                 105                 110        
 Ile Gly Lys Gly Gly Ser Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly
         115                 120                 125            
 Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg
     130                 135                 140                
 Ala Val Thr Ile Ser Gly Thr Pro Asp Ala Ile Ile Gln Cys Val Lys
 145                 150                 155                 160
 Gln Ile Cys Val Val Met Leu Glu Ser Pro Pro Lys Gly Ala Thr Ile
                 165                 170                 175    
 Pro Tyr Arg Pro Lys Pro Ala Ser Thr Pro Val Ile Phe Ala Gly Gly
             180                 185                 190        
 Gln Ala Tyr Thr Ile Gln Gly Gln Tyr Ala Ile Pro His Pro Asp Gln
         195                 200                 205            
 Leu Thr Lys Leu His Gln Leu Ala Met Gln Gln Thr Pro Phe Pro Pro
     210                 215                 220                
 Leu Gly Gln Thr Asn Pro Ala Phe Pro Gly Glu Lys Leu Pro Leu His
 225                 230                 235                 240
 Ser Ser Glu Glu Ala Gln Asn Leu Met Gly Gln Ser Ser Gly Leu Asp
                 245                 250                 255    
 Ala Ser Pro Pro Ala Ser Thr His Glu Leu Thr Ile Pro Asn Asp Leu
             260                 265                 270        
 Ile Gly Cys Ile Ile Gly Arg Gln Gly Thr Lys Ile Asn Glu Ile Arg
         275                 280                 285            
 Gln Met Ser Gly Ala Gln Ile Lys Ile Ala Asn Ala Thr Glu Gly Ser
     290                 295                 300                
 Ser Glu Arg Gln Ile Thr Ile Thr Gly Thr Pro Ala Asn Ile Ser Leu
 305                 310                 315                 320
 Ala Gln Tyr Leu Ile Asn Ala Arg Leu Thr Ser Glu Val Thr Gly Met
                 325                 330                 335    
 Gly Thr Leu
            



      <210> 1205
      <211> 172
      <212> PRT
      <213> Homo sapiens


      <400> 1205
 Met Leu Pro Trp Gln Phe Ala Gln Phe Ile Leu Phe Thr Gln Ile Ala
   1               5                  10                  15    
 Ser Leu Phe Pro Met Tyr Val Val Gly Tyr Ile Glu Pro Ser Lys Phe
              20                  25                  30        
 Gln Lys Ile Ile Tyr Met Asn Met Ile Ser Val Thr Leu Ser Phe Ile
          35                  40                  45            
 Leu Met Phe Gly Asn Ser Met Tyr Leu Ser Ser Ser Tyr Ser Ser Ser
      50                  55                  60                
 Leu Leu Met Thr Trp Ala Ile Ile Leu Lys Arg Asn Glu Ile Gln Lys
  65                  70                  75                  80
 Leu Gly Val Ser Lys Leu Asn Phe Trp Leu Ile Gln Gly Ser Ala Trp
                  85                  90                  95    
 Trp Cys Gly Thr Ile Ile Leu Lys Phe Leu Thr Ser Lys Ile Leu Gly
             100                 105                 110        
 Val Ser Asp His Ile Arg Leu Ser Asp Leu Ile Ala Ala Arg Ile Leu
         115                 120                 125            
 Arg Tyr Thr Asp Phe Asp Thr Leu Ile Tyr Thr Cys Ala Pro Glu Phe
     130                 135                 140                
 Asp Phe Met Glu Lys Ala Thr Pro Leu Arg Tyr Thr Lys Thr Leu Leu
 145                 150                 155                 160
 Leu Pro Val Val Met Val Ile Thr Cys Phe Ile Phe
                 165                 170        



      <210> 1206
      <211> 341
      <212> PRT
      <213> Homo sapiens


      <400> 1206
 Met Ala Ala Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Thr
   1               5                  10                  15    
 Val Arg Asp Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu Arg Asp
              20                  25                  30        
 Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp Gly Ala
          35                  40                  45            
 Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys Arg Ile
      50                  55                  60                
 Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala Val Gly
  65                  70                  75                  80
 Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr Phe Asn
                  85                  90                  95    
 Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala Lys Thr
             100                 105                 110        
 Tyr Tyr Met Ser Gly Gly Leu Gln Pro Val Pro Ile Val Phe Arg Gly
         115                 120                 125            
 Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln Cys Phe
     130                 135                 140                
 Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser Pro Trp
 145                 150                 155                 160
 Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg Asp Asn
                 165                 170                 175    
 Asn Pro Val Val Val Leu Glu Asn Glu Leu Met Tyr Gly Val Pro Phe
             180                 185                 190        
 Glu Phe Pro Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro Ile Gly
         195                 200                 205            
 Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Thr Val Val Ser His
     210                 215                 220                
 Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu Ser Lys
 225                 230                 235                 240
 Glu Gly Val Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg Pro Met
                 245                 250                 255    
 Asp Met Glu Thr Ile Glu Ala Ser Val Met Lys Thr Asn His Leu Val
             260                 265                 270        
 Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu Ile Cys
         275                 280                 285            
 Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala Pro Ala
     290                 295                 300                
 Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys Ile Leu
 305                 310                 315                 320
 Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala Ile Lys
                 325                 330                 335    
 Lys Thr Leu Asn Ile
             340    



      <210> 1207
      <211> 390
      <212> PRT
      <213> Homo sapiens


      <400> 1207
 Met Gly Pro Arg Ala Val Pro Gly Leu Arg Leu Ala Leu Leu Leu Leu
   1               5                  10                  15    
 Leu Val Leu Gly Thr Pro Lys Ser Gly Val Gln Gly Gln Glu Gly Leu
              20                  25                  30        
 Asp Phe Pro Glu Tyr Asp Gly Val Asp Arg Val Ile Asn Val Asn Ala
          35                  40                  45            
 Lys Asn Tyr Lys Asn Val Phe Lys Lys Tyr Glu Val Leu Ala Leu Leu
      50                  55                  60                
 Tyr His Glu Pro Pro Glu Asp Asp Lys Ala Ser Gln Arg Gln Phe Glu
  65                  70                  75                  80
 Met Glu Glu Leu Ile Leu Glu Leu Ala Ala Gln Val Leu Glu Asp Lys
                  85                  90                  95    
 Gly Val Gly Phe Gly Leu Val Asp Ser Glu Lys Asp Ala Ala Val Ala
             100                 105                 110        
 Lys Lys Leu Gly Leu Thr Glu Val Asp Ser Met Tyr Val Phe Lys Gly
         115                 120                 125            
 Asp Glu Val Ile Glu Tyr Asp Gly Glu Phe Ser Ala Asp Thr Ile Val
     130                 135                 140                
 Glu Phe Leu Leu Asp Val Leu Glu Asp Pro Val Glu Leu Ile Glu Gly
 145                 150                 155                 160
 Glu Arg Glu Leu Gln Ala Phe Glu Asn Ile Glu Asp Glu Ile Lys Leu
                 165                 170                 175    
 Ile Gly Tyr Phe Lys Ser Lys Asp Ser Glu His Tyr Lys Ala Phe Glu
             180                 185                 190        
 Asp Ala Ala Glu Glu Phe His Pro Tyr Ile Pro Phe Phe Ala Thr Phe
         195                 200                 205            
 Asp Ser Lys Val Ala Lys Lys Leu Thr Leu Lys Leu Asn Glu Ile Asp
     210                 215                 220                
 Phe Tyr Glu Ala Phe Met Glu Glu Pro Val Thr Ile Pro Asp Lys Pro
 225                 230                 235                 240
 Asn Ser Glu Glu Glu Ile Val Asn Phe Val Glu Glu His Arg Arg Ser
                 245                 250                 255    
 Thr Leu Arg Lys Leu Lys Pro Glu Ser Met Tyr Glu Thr Trp Glu Asp
             260                 265                 270        
 Asp Met Asp Gly Ile His Ile Val Ala Phe Ala Glu Glu Ala Asp Pro
         275                 280                 285            
 Asp Gly Phe Glu Phe Leu Glu Thr Leu Lys Ala Val Ala Gln Asp Asn
     290                 295                 300                
 Thr Glu Asn Pro Asp Leu Ser Ile Ile Trp Ile Asp Pro Asp Asp Phe
 305                 310                 315                 320
 Pro Leu Leu Val Pro Tyr Trp Glu Lys Thr Phe Asp Ile Asp Leu Ser
                 325                 330                 335    
 Ala Pro Gln Ile Gly Val Val Asn Val Thr Asp Ala Asp Arg Leu Trp
             340                 345                 350        
 Met Glu Met Asp Asp Glu Glu Asp Leu Pro Ser Ala Glu Glu Leu Glu
         355                 360                 365            
 Asp Trp Leu Glu Asp Val Leu Glu Gly Glu Ile Asn Thr Glu Asp Asp
     370                 375                 380                
 Asp Asp Asp Asp Asp Asp
 385                 390



      <210> 1208
      <211> 63
      <212> PRT
      <213> Homo sapiens


      <400> 1208
 Met Cys Tyr Leu Leu Leu Leu Leu Ile Gln Thr Ala Glu Leu Leu Ile
   1               5                  10                  15    
 His Pro Gln Gly Leu Gln Ala Val Ser Asn Gly Glu Ser Ala Leu Lys
              20                  25                  30        
 Gly Thr Arg Pro Thr Phe Ser Ser Pro Phe Ile Leu Asn Ser Pro Ala
          35                  40                  45            
 Ile Phe Leu Leu Ser Met Gly Glu Val Gly Asp Gly Asp Leu Asp
      50                  55                  60            



      <210> 1209
      <211> 928
      <212> PRT
      <213> Homo sapiens


      <400> 1209
 Met Gly Gly Ser Ala Ser Ser Gln Leu Asp Glu Gly Lys Cys Ala Tyr
   1               5                  10                  15    
 Ile Arg Gly Lys Thr Glu Ala Ala Ile Lys Asn Phe Ser Pro Tyr Tyr
              20                  25                  30        
 Ser Arg Gln Tyr Ser Val Ala Phe Cys Asn His Val Arg Thr Glu Val
          35                  40                  45            
 Glu Gln Gln Arg Asp Leu Thr Ser Gln Phe Leu Lys Thr Lys Pro Pro
      50                  55                  60                
 Leu Ala Pro Gly Thr Ile Leu Tyr Glu Ala Glu Leu Ser Gln Phe Ser
  65                  70                  75                  80
 Glu Asp Ile Lys Lys Trp Lys Glu Arg Tyr Val Val Val Lys Asn Asp
                  85                  90                  95    
 Tyr Ala Val Glu Ser Tyr Glu Asn Lys Glu Ala Tyr Gln Arg Gly Ala
             100                 105                 110        
 Ala Pro Lys Cys Arg Ile Leu Pro Ala Gly Gly Lys Val Leu Thr Ser
         115                 120                 125            
 Glu Asp Glu Tyr Asn Leu Leu Ser Asp Arg His Phe Pro Asp Pro Leu
     130                 135                 140                
 Ala Ser Ser Glu Lys Glu Asn Thr Gln Pro Phe Val Val Leu Pro Lys
 145                 150                 155                 160
 Glu Phe Pro Val Tyr Leu Trp Gln Pro Phe Phe Arg His Gly Tyr Phe
                 165                 170                 175    
 Cys Phe His Glu Ala Ala Asp Gln Lys Arg Phe Ser Ala Leu Leu Ser
             180                 185                 190        
 Asp Cys Val Arg His Leu Asn His Asp Tyr Met Lys Gln Met Thr Phe
         195                 200                 205            
 Glu Ala Gln Ala Phe Leu Glu Ala Val Gln Phe Phe Arg Gln Glu Lys
     210                 215                 220                
 Gly His Tyr Gly Ser Trp Glu Met Ile Thr Gly Asp Glu Ile Gln Ile
 225                 230                 235                 240
 Leu Ser Asn Leu Val Met Glu Glu Leu Leu Pro Thr Leu Gln Thr Asp
                 245                 250                 255    
 Leu Leu Pro Lys Met Lys Gly Lys Lys Asn Asp Arg Lys Arg Ala Gly
             260                 265                 270        
 Leu Gly Leu Leu Glu Glu Ala Tyr Thr Leu Val Gln His Gln Val Ser
         275                 280                 285            
 Glu Gly Leu Ser Ala Leu Lys Glu Glu Cys Arg Ala Leu Thr Lys Gly
     290                 295                 300                
 Leu Glu Gly Thr Ile Arg Ser Asp Met Asp Gln Ile Val Asn Ser Lys
 305                 310                 315                 320
 Asn Tyr Leu Ile Gly Lys Ile Lys Ala Met Val Ala Gln Pro Ala Glu
                 325                 330                 335    
 Lys Ser Cys Leu Glu Ser Val Gln Pro Phe Leu Ala Ser Ile Leu Glu
             340                 345                 350        
 Glu Leu Met Gly Pro Val Ser Ser Gly Phe Ser Glu Val Arg Val Leu
         355                 360                 365            
 Phe Glu Lys Glu Val Asn Glu Val Ser Gln Asn Phe Gln Thr Thr Lys
     370                 375                 380                
 Asp Ser Val Gln Leu Lys Glu His Leu Asp Arg Leu Met Asn Leu Pro
 385                 390                 395                 400
 Leu His Ser Val Lys Met Glu Pro Cys Tyr Thr Lys Val Asn Leu Leu
                 405                 410                 415    
 His Glu Arg Leu Gln Asp Leu Lys Ser Arg Phe Arg Phe Pro His Ile
             420                 425                 430        
 Asp Leu Val Val Gln Arg Thr Gln Asn Tyr Met Gln Glu Leu Met Glu
         435                 440                 445            
 Asn Ala Val Phe Thr Phe Glu Gln Leu Leu Ser Pro His Leu Gln Gly
     450                 455                 460                
 Glu Ala Ser Lys Thr Ala Val Ala Ile Glu Lys Val Lys Leu Arg Val
 465                 470                 475                 480
 Leu Lys Gln Tyr Asp Tyr Asp Ser Ser Thr Ile Arg Lys Lys Ile Phe
                 485                 490                 495    
 Gln Glu Ala Leu Val Gln Ile Thr Leu Pro Thr Val Gln Lys Ala Leu
             500                 505                 510        
 Ala Ser Thr Cys Lys Pro Glu Leu Gln Lys Tyr Glu Gln Phe Ile Phe
         515                 520                 525            
 Ala Asp His Thr Asn Met Ile His Val Glu Asn Val Tyr Glu Glu Ile
     530                 535                 540                
 Leu His Gln Ile Leu Leu Asp Glu Thr Leu Lys Val Ile Lys Glu Ala
 545                 550                 555                 560
 Ala Ile Leu Lys Lys His Asn Leu Phe Glu Asp Asn Met Ala Leu Pro
                 565                 570                 575    
 Ser Glu Ser Val Ser Ser Leu Thr Asp Leu Lys Pro Pro Thr Gly Ser
             580                 585                 590        
 Asn Gln Ala Ser Pro Ala Arg Arg Ala Ser Ala Ile Leu Pro Gly Val
         595                 600                 605            
 Pro Gly Ser Glu Thr Leu Ser Asn Glu Val Phe Gln Glu Ser Glu Glu
     610                 615                 620                
 Glu Lys Gln Pro Glu Val Pro Ser Ser Leu Ala Lys Gly Glu Ser Leu
 625                 630                 635                 640
 Ser Leu Pro Gly Pro Ser Pro Pro Pro Asp Gly Thr Glu Gln Val Ile
                 645                 650                 655    
 Ile Ser Arg Val Asp Asp Pro Val Val Asn Pro Val Ala Thr Glu Asp
             660                 665                 670        
 Thr Ala Gly Leu Pro Gly Thr Cys Ser Ser Glu Leu Glu Phe Gly Gly
         675                 680                 685            
 Thr Leu Glu Asp Glu Glu Pro Ala Gln Glu Glu Pro Glu Pro Ile Thr
     690                 695                 700                
 Ala Ser Gly Ser Leu Lys Ala Leu Arg Lys Leu Leu Thr Ala Ser Val
 705                 710                 715                 720
 Glu Val Pro Val Asp Ser Ala Pro Val Met Glu Glu Asp Thr Asn Gly
                 725                 730                 735    
 Glu Ser His Val Pro Gln Glu Asn Glu Glu Glu Glu Glu Lys Glu Pro
             740                 745                 750        
 Ser Gln Ala Ala Ala Ile His Pro Asp Asn Cys Glu Glu Ser Glu Val
         755                 760                 765            
 Ser Glu Arg Glu Ala Gln Pro Pro Cys Pro Glu Ala His Gly Glu Glu
     770                 775                 780                
 Leu Gly Gly Phe Pro Glu Val Gly Ser Pro Ala Ser Pro Pro Ala Ser
 785                 790                 795                 800
 Gly Gly Leu Thr Glu Glu Pro Leu Gly Pro Met Glu Gly Glu Leu Pro
                 805                 810                 815    
 Gly Glu Ala Cys Thr Leu Thr Ala His Glu Gly Arg Gly Gly Lys Cys
             820                 825                 830        
 Thr Glu Glu Gly Asp Ala Ser Gln Gln Glu Gly Cys Thr Leu Gly Ser
         835                 840                 845            
 Asp Pro Ile Cys Leu Ser Glu Ser Gln Val Ser Glu Glu Gln Glu Glu
     850                 855                 860                
 Met Gly Gly Gln Ser Ser Ala Ala Gln Ala Thr Ala Ser Val Asn Ala
 865                 870                 875                 880
 Glu Glu Ile Lys Val Ala Arg Ile His Glu Cys Gln Trp Val Val Glu
                 885                 890                 895    
 Asp Ala Pro Asn Pro Asp Val Leu Leu Ser His Lys Asp Asp Val Lys
             900                 905                 910        
 Glu Gly Glu Gly Gly Gln Glu Ser Phe Pro Glu Leu Pro Ser Glu Glu
         915                 920                 925            





      <210> 1210
      <211> 257
      <212> PRT
      <213> Homo sapiens


      <400> 1210
 Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala
   1               5                  10                  15    
 Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu
              20                  25                  30        
 Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His
          35                  40                  45            
 Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu
      50                  55                  60                
 Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro
  65                  70                  75                  80
 Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Gln Leu Arg
                  85                  90                  95    
 Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser
             100                 105                 110        
 Arg Leu Gly Asp Arg Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr
         115                 120                 125            
 Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe
     130                 135                 140                
 Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val
 145                 150                 155                 160
 Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp
                 165                 170                 175    
 Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro
             180                 185                 190        
 Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser
         195                 200                 205            
 Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe
     210                 215                 220                
 Arg Cys Gln Val Gln Leu Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr
 225                 230                 235                 240
 Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp
                 245                 250                 255    
 Gly
    



      <210> 1211
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 1211
 Met Glu Phe His Tyr Val Ala Gln Ala Asp Leu Glu Leu Leu Thr Ser
   1               5                  10                  15    
 Ser Asn Pro Pro Ala Ser Ala Ser Gln Ser Thr Gly Ile Thr Gly Gly
              20                  25                  30        
 Ser His Arg Ala Arg Pro Gly Pro Val His Phe Ile Asp Lys Val Thr
          35                  40                  45            
 Asp Lys Pro Ser His Ser His Pro Phe Ala Leu Lys Glu Asn Trp Asn
      50                  55                  60                
 Leu Asn Pro Glu Pro Ser Ser Pro Pro Ser Pro Leu Phe Leu Glu Ala
  65                  70                  75                  80
 Pro Ser Arg Gln Ala Ser Gln His His Gly Ala Ser Pro Gly Ala Gly
                  85                  90                  95    
 Thr Ser Ala Gly Cys Pro Phe Glu Lys Cys Cys Ser Thr Glu Pro Cys
             100                 105                 110        
 Leu Ser Gly Leu Gly Asp Val Gly Arg Gly Glu Ala Ala Ser Leu Arg
         115                 120                 125            
 Ala Arg Pro Gly Ser Gly Ala Ser Arg Gly Gln Gly Pro Gly Ser Arg
     130                 135                 140                
 Val Ser Cys Arg Arg Asp Leu Gly Lys Pro Leu His Ala Pro Ala Gly
 145                 150                 155                 160
 Phe Ser Ala Gly Glu Val His Thr Thr Pro Leu Gly Asn Leu Gly Ala
                 165                 170                 175    





      <210> 1212
      <211> 26
      <212> PRT
      <213> Homo sapiens


      <400> 1212
 Met Asp Thr Gln Gly Ala Ser Phe Ser Leu Ala Ser Asn Leu Pro Met
   1               5                  10                  15    
 Met Ile Pro Asp Ser Lys Lys Phe Leu Phe
              20                  25    



      <210> 1213
      <211> 934
      <212> PRT
      <213> Homo sapiens


      <400> 1213
 Met Val Pro Glu Ala Trp Arg Ser Gly Leu Val Ser Thr Gly Arg Val
   1               5                  10                  15    
 Val Gly Val Leu Leu Leu Leu Gly Ala Leu Asn Lys Ala Ser Thr Val
              20                  25                  30        
 Ile His Tyr Glu Ile Pro Glu Glu Arg Glu Lys Gly Phe Ala Val Gly
          35                  40                  45            
 Asn Val Val Ala Asn Leu Gly Leu Asp Leu Gly Ser Leu Ser Ala Arg
      50                  55                  60                
 Arg Phe Arg Val Val Ser Gly Ala Ser Arg Arg Phe Phe Glu Val Asn
  65                  70                  75                  80
 Arg Glu Thr Gly Glu Met Phe Val Asn Asp Arg Leu Asp Arg Glu Glu
                  85                  90                  95    
 Leu Cys Gly Thr Leu Pro Ser Cys Thr Val Thr Leu Glu Leu Val Val
             100                 105                 110        
 Glu Asn Pro Leu Glu Leu Phe Ser Val Glu Val Val Ile Gln Asp Ile
         115                 120                 125            
 Asn Asp Asn Asn Pro Ala Phe Pro Thr Gln Glu Met Lys Leu Glu Ile
     130                 135                 140                
 Ser Glu Ala Val Ala Pro Gly Thr Arg Phe Pro Leu Glu Ser Ala His
 145                 150                 155                 160
 Asp Pro Asp Val Gly Ser Asn Ser Leu Gln Thr Tyr Glu Leu Ser Arg
                 165                 170                 175    
 Asn Glu Tyr Phe Ala Leu Arg Val Gln Thr Arg Glu Asp Ser Thr Lys
             180                 185                 190        
 Tyr Ala Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Arg Glu Pro
         195                 200                 205            
 Ser Leu Gln Leu Val Leu Thr Ala Leu Asp Gly Gly Thr Pro Ala Leu
     210                 215                 220                
 Ser Ala Ser Leu Pro Ile His Ile Lys Val Leu Asp Ala Asn Asp Asn
 225                 230                 235                 240
 Ala Pro Val Phe Asn Gln Ser Leu Tyr Arg Ala Arg Val Leu Glu Asp
                 245                 250                 255    
 Ala Pro Ser Gly Thr Arg Val Val Gln Val Leu Ala Thr Asp Leu Asp
             260                 265                 270        
 Glu Gly Pro Asn Gly Glu Ile Ile Tyr Ser Phe Gly Ser His Asn Arg
         275                 280                 285            
 Ala Gly Val Arg Gln Leu Phe Ala Leu Asp Leu Val Thr Gly Met Leu
     290                 295                 300                
 Thr Ile Lys Gly Arg Leu Asp Phe Glu Asp Thr Lys Leu His Glu Ile
 305                 310                 315                 320
 Tyr Ile Gln Ala Lys Asp Lys Gly Ala Asn Pro Glu Gly Ala His Cys
                 325                 330                 335    
 Lys Val Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile
             340                 345                 350        
 Thr Val Thr Ser Val Tyr Ser Pro Val Pro Glu Asp Ala Pro Leu Gly
         355                 360                 365            
 Thr Val Ile Ala Leu Leu Ser Val Thr Asp Leu Asp Ala Gly Glu Asn
     370                 375                 380                
 Gly Leu Val Thr Cys Glu Val Pro Pro Gly Leu Pro Phe Ser Leu Thr
 385                 390                 395                 400
 Ser Ser Leu Lys Asn Tyr Phe Thr Leu Lys Thr Ser Ala Asp Leu Asp
                 405                 410                 415    
 Arg Glu Thr Val Pro Glu Tyr Asn Leu Ser Ile Thr Ala Arg Asp Ala
             420                 425                 430        
 Gly Thr Pro Ser Leu Ser Ala Leu Thr Ile Val Arg Val Gln Val Ser
         435                 440                 445            
 Asp Ile Asn Asp Asn Pro Pro Gln Ser Ser Gln Ser Ser Tyr Asp Val
     450                 455                 460                
 Tyr Ile Glu Glu Asn Asn Leu Pro Gly Ala Pro Ile Leu Asn Leu Ser
 465                 470                 475                 480
 Val Trp Asp Pro Asp Ala Pro Gln Asn Ala Arg Leu Ser Phe Phe Leu
                 485                 490                 495    
 Leu Glu Gln Gly Ala Glu Thr Gly Leu Val Gly Arg Tyr Phe Thr Ile
             500                 505                 510        
 Asn Arg Asp Asn Gly Ile Val Ser Ser Leu Val Pro Leu Asp Tyr Glu
         515                 520                 525            
 Asp Arg Arg Glu Phe Glu Leu Thr Ala His Ile Ser Asp Gly Gly Thr
     530                 535                 540                
 Pro Val Leu Ala Thr Asn Ile Ser Val Asn Ile Phe Val Thr Asp Arg
 545                 550                 555                 560
 Asn Asp Asn Ala Pro Gln Val Leu Tyr Pro Arg Pro Gly Gly Ser Ser
                 565                 570                 575    
 Val Glu Met Leu Pro Arg Gly Thr Ser Ala Gly His Leu Val Ser Arg
             580                 585                 590        
 Val Val Gly Trp Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr
         595                 600                 605            
 Ser Leu Leu Gly Ser Pro Asn Gln Ser Leu Phe Ala Ile Gly Leu His
     610                 615                 620                
 Thr Gly Gln Ile Ser Thr Ala Arg Pro Val Gln Asp Thr Asp Ser Pro
 625                 630                 635                 640
 Arg Gln Thr Leu Thr Val Leu Ile Lys Asp Asn Gly Glu Pro Ser Leu
                 645                 650                 655    
 Ser Thr Thr Ala Thr Leu Thr Val Ser Val Thr Glu Asp Ser Pro Glu
             660                 665                 670        
 Ala Arg Ala Glu Phe Pro Ser Gly Ser Ala Pro Arg Glu Gln Lys Lys
         675                 680                 685            
 Asn Leu Thr Phe Tyr Leu Leu Leu Ser Leu Ile Leu Val Ser Val Gly
     690                 695                 700                
 Phe Val Val Thr Val Phe Gly Val Ile Ile Phe Lys Val Tyr Lys Trp
 705                 710                 715                 720
 Lys Gln Ser Arg Asp Leu Tyr Arg Ala Pro Val Ser Ser Leu Tyr Arg
                 725                 730                 735    
 Thr Pro Gly Pro Ser Leu His Ala Asp Ala Val Arg Gly Gly Leu Met
             740                 745                 750        
 Ser Pro His Leu Tyr His Gln Val Tyr Leu Thr Thr Asp Ser Arg Pro
         755                 760                 765            
 Gly Asp Pro Leu Leu Lys Lys Pro Gly Ala Ala Ser Pro Leu Ala Ser
     770                 775                 780                
 Arg Gln Asn Thr Leu Arg Ser Cys Asp Pro Val Phe Tyr Arg Gln Val
 785                 790                 795                 800
 Leu Gly Ala Glu Ser Ala Pro Pro Gly Gln Gln Ala Pro Pro Asn Thr
                 805                 810                 815    
 Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln
             820                 825                 830        
 Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu
         835                 840                 845            
 Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly
     850                 855                 860                
 Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg
 865                 870                 875                 880
 Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn
                 885                 890                 895    
 Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys
             900                 905                 910        
 Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser
         915                 920                 925            
 Gly Lys Lys Glu Lys Lys
     930                



      <210> 1214
      <211> 317
      <212> PRT
      <213> Homo sapiens


      <400> 1214
 Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val
   1               5                  10                  15    
 Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly
              20                  25                  30        
 Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys
          35                  40                  45            
 Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys
      50                  55                  60                
 Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser
  65                  70                  75                  80
 Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr
                  85                  90                  95    
 Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu
             100                 105                 110        
 Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr
         115                 120                 125            
 Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val
     130                 135                 140                
 His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp
 145                 150                 155                 160
 Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val
                 165                 170                 175    
 Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu
             180                 185                 190        
 Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile
         195                 200                 205            
 Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys
     210                 215                 220                
 Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu
 225                 230                 235                 240
 His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu
                 245                 250                 255    
 Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys
             260                 265                 270        
 Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr
         275                 280                 285            
 Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser
     290                 295                 300                
 Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Val Ile
 305                 310                 315        



      <210> 1215
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 1215
 Met Gly Cys Cys Gly Cys Gly Ser Cys Gly Gly Cys Gly Gly Arg Cys
   1               5                  10                  15    
 Gly Gly Gly Cys Gly Gly Gly Cys Ser Gly Gly Cys Gly Gly Gly Cys
              20                  25                  30        
 Gly Gly Gly Cys Gly Gly Gly Cys Gly Ser Cys Thr Thr Cys Arg Cys
          35                  40                  45            
 Tyr Arg Val Gly Cys Cys Ser Ser Cys Cys Pro Cys Cys Arg Gly Cys
      50                  55                  60                
 Cys Gly Gly Cys Cys Ser Thr Pro Val Ile Cys Cys Cys Arg Arg Thr
  65                  70                  75                  80
 Cys Gly Ser Cys Gly Cys Gly Tyr Gly Lys Gly Cys Cys Gln Gln Lys
                  85                  90                  95    
 Cys Cys Cys Gln Lys Gln Cys Cys Cys
             100                 105



      <210> 1216
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 1216
 Met Phe Arg Asp Lys Tyr Lys Ile Gln Asn Ala Lys Glu Asn Thr Lys
   1               5                  10                  15    
 Gln Asn Gln Lys Ile Glu Leu Ser Gln Arg Thr Ile Asn Gly Arg Asp
              20                  25                  30        
 Arg Arg Val Pro Leu Leu His Phe Asn Lys Ala Glu Leu Pro Thr Leu
          35                  40                  45            
 Asn Ile Leu Leu Glu Met Ala Glu Leu Asn Pro Gly Gly Ser Val Leu
      50                  55                  60                
 Lys Val Thr Ala Asn Cys Asn Thr Gln Ala Ala Ala Leu Ile Ser Arg
  65                  70                  75                  80
 Trp Leu Lys Leu Cys Ile Pro Thr Leu Ser Thr Ile Thr Phe Gly Ser
                  85                  90                  95    
 Ser Thr Gln Asn Arg Lys Arg Gln Leu Phe
             100                 105    



      <210> 1217
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 1217
 Met Thr Ser Pro Pro Pro His Gln Gly Trp Glu Gln Arg Gly Cys Gly
   1               5                  10                  15    
 Glu Ser Gln Val Pro Leu Ala Leu Ser Arg Val Phe Ser Thr Ser His
              20                  25                  30        
 Tyr Cys Leu Leu Leu Val Ala Asn Gln Ser Ile Phe Phe Pro Cys Leu
          35                  40                  45            
 Trp Ala Val Glu Ser Ala Ala Gly Cys Thr Leu His Leu Pro Thr Glu
      50                  55                  60                
 Leu Gly Lys Glu Asp Asn Gln
  65                  70    



      <210> 1218
      <211> 47
      <212> PRT
      <213> Homo sapiens


      <400> 1218
 Met Ser Leu Leu Leu Pro Pro Leu Ala Leu Leu Leu Leu Leu Ala Ala
   1               5                  10                  15    
 Leu Val Ala Pro Ala Thr Ala Ala Thr Ala Tyr Arg Pro Asp Trp Asn
              20                  25                  30        
 Arg Leu Ser Gly Leu Thr Arg Ala Arg Val Glu Thr Cys Gly Gly
          35                  40                  45        



      <210> 1219
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 1219
 Met Tyr Leu Ser Leu Leu Ile Leu Leu Leu Glu Asn Val Ser Gly Phe
   1               5                  10                  15    
 Pro Phe Pro Leu Ile Phe Gln Leu His Ala Ser Pro Gly His Lys Ile
              20                  25                  30        
 Leu Pro Asp Cys Met Ile Tyr Ser Ile Thr Val Ser Leu Met Phe Pro
          35                  40                  45            
 Val Val Asp Tyr Ile Ser Thr Leu
      50                  55    



      <210> 1220
      <211> 36
      <212> PRT
      <213> Homo sapiens


      <400> 1220
 Met Glu Val Leu Phe Asp Ser Leu Leu Phe Ser Ser Phe Ile Phe Pro
   1               5                  10                  15    
 Ser Gln Ser Leu Leu Ser Arg Thr Ser Ala Phe Ser His Lys Ser Asn
              20                  25                  30        
 Gly Leu Ser Glu
          35    



      <210> 1221
      <211> 279
      <212> PRT
      <213> Homo sapiens


      <400> 1221
 Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala
   1               5                  10                  15    
 Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Asn
              20                  25                  30        
 Ala Val Ser Ser Glu Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro
          35                  40                  45            
 Ser Lys Ser Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu
      50                  55                  60                
 Asp Asp Asp Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp
  65                  70                  75                  80
 Ser Asp Asp Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser
                  85                  90                  95    
 His His Ser Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp
             100                 105                 110        
 Leu Pro Ala Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr
         115                 120                 125            
 Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser
     130                 135                 140                
 Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu
 145                 150                 155                 160
 Asp Ile Thr Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys
                 165                 170                 175    
 Ala Ile Pro Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser
             180                 185                 190        
 Arg Gly Lys Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala
         195                 200                 205            
 Glu Thr His Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn
     210                 215                 220                
 Asp Glu Ser Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser
 225                 230                 235                 240
 Lys Val Ser Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp
                 245                 250                 255    
 Met Leu Val Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys
             260                 265                 270        
 Ile Ser Val Phe Leu Met Asn
         275                



      <210> 1222
      <211> 446
      <212> PRT
      <213> Homo sapiens


      <400> 1222
 Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val
   1               5                  10                  15    
 Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys
              20                  25                  30        
 His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro
          35                  40                  45            
 Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu
      50                  55                  60                
 Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val
  65                  70                  75                  80
 Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln
                  85                  90                  95    
 His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro
             100                 105                 110        
 Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn
         115                 120                 125            
 Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser
     130                 135                 140                
 Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys
 145                 150                 155                 160
 Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu Val Ser Ala Asn
                 165                 170                 175    
 Arg Leu Phe Gly Asp Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp
             180                 185                 190        
 Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys
         195                 200                 205            
 Glu Gly Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn Glu Leu
     210                 215                 220                
 Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu Trp Lys
 225                 230                 235                 240
 Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr Lys Ala
                 245                 250                 255    
 Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln Glu Gly Lys Phe
             260                 265                 270        
 Arg Tyr Arg Arg Val Ala Glu Ser Thr Gln Val Leu Glu Leu Pro Phe
         275                 280                 285            
 Lys Gly Asp Asp Ile Thr Met Val Leu Ile Leu Pro Lys Pro Glu Lys
     290                 295                 300                
 Ser Pro Ala Lys Val Glu Lys Glu Leu Thr Pro Glu Val Leu Gln Glu
 305                 310                 315                 320
 Trp Leu Asp Glu Leu Glu Glu Met Met Leu Val Val His Met Pro Arg
                 325                 330                 335    
 Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln Leu Gln Asp Met
             340                 345                 350        
 Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro Gly Ile
         355                 360                 365            
 Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe His Lys
     370                 375                 380                
 Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala Ala Ser Thr
 385                 390                 395                 400
 Ala Val Val Ile Ala Gly Arg Ser Leu Asn Pro Asn Arg Val Thr Phe
                 405                 410                 415    
 Lys Ala Asn Met Pro Phe Leu Val Phe Ile Arg Glu Val Pro Leu Asn
             420                 425                 430        
 Thr Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys
         435                 440                 445    



      <210> 1223
      <211> 381
      <212> PRT
      <213> Homo sapiens


      <400> 1223
 Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu
   1               5                  10                  15    
 Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu
              20                  25                  30        
 Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg
          35                  40                  45            
 Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu
      50                  55                  60                
 Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro
  65                  70                  75                  80
 Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile
                  85                  90                  95    
 Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn
             100                 105                 110        
 Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp
         115                 120                 125            
 Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys
     130                 135                 140                
 Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp
 145                 150                 155                 160
 Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln
                 165                 170                 175    
 Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu
             180                 185                 190        
 Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys
         195                 200                 205            
 Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro
     210                 215                 220                
 Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu
 225                 230                 235                 240
 Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Ser Gly Thr Val Thr
                 245                 250                 255    
 Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met
             260                 265                 270        
 Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu
         275                 280                 285            
 Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr
     290                 295                 300                
 His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile
 305                 310                 315                 320
 Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser
                 325                 330                 335    
 Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly
             340                 345                 350        
 Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg
         355                 360                 365            
 Arg Gly Glu Glu Arg Lys Ala Pro Glu Thr Gln Glu Glu
     370                 375                 380    



      <210> 1224
      <211> 111
      <212> PRT
      <213> Homo sapiens


      <400> 1224
 Met Glu Trp Glu Trp Ser Cys Met Ala Val Val Ser Pro Ala Ala Cys
   1               5                  10                  15    
 Ala Gly Tyr Val Ala Arg Gly Ala His His Ser Ser Gly Met Ala Arg
              20                  25                  30        
 Leu Glu Ala Leu Gly Pro Leu Gly Leu Cys Thr Pro Thr Pro Ser His
          35                  40                  45            
 Leu Ala Cys Leu Leu Ile Phe Met Gly Ala Trp Gly Asp Gln Leu Trp
      50                  55                  60                
 Leu Leu Val Ile Val Ala Gln Val Thr Val His Thr Ser Trp Asp Gln
  65                  70                  75                  80
 Asp Ile Arg Ala Leu Arg Arg Val Lys Gly Pro Ser Gly Pro Ser Leu
                  85                  90                  95    
 Leu Leu Thr Ala Gly Lys Cys Lys Arg Val Asp Gln Ser Thr Lys
             100                 105                 110    



      <210> 1225
      <211> 1545
      <212> PRT
      <213> Homo sapiens


      <400> 1225
 Met Trp Val Tyr Asp Glu Asp Val Gly Met Asn Cys Arg Glu Val Thr
   1               5                  10                  15    
 Phe Val Pro Gly Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala
              20                  25                  30        
 Ala Asp Asn Lys Gln Arg Asp Lys Asn Met Thr Cys Ile Lys Val Ser
          35                  40                  45            
 Ile Asp Pro Glu Ser Asn Ile Ile Ser Ile Trp Asn Asn Gly Lys Gly
      50                  55                  60                
 Ile Pro Val Val Glu His Lys Val Glu Lys Val Tyr Val Pro Ala Leu
  65                  70                  75                  80
 Ile Phe Gly Gln Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys
                  85                  90                  95    
 Lys Val Thr Gly Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile
             100                 105                 110        
 Phe Ser Thr Lys Phe Thr Val Glu Thr Ala Cys Lys Glu Tyr Lys His
         115                 120                 125            
 Ser Phe Lys Gln Thr Trp Met Asn Asn Met Met Lys Thr Ser Glu Ala
     130                 135                 140                
 Lys Ile Lys His Phe Asp Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln
 145                 150                 155                 160
 Pro Asp Leu Ser Lys Phe Lys Met Glu Lys Leu Asp Lys Asp Ile Val
                 165                 170                 175    
 Ala Leu Met Thr Arg Arg Ala Tyr Asp Leu Ala Gly Ser Cys Arg Gly
             180                 185                 190        
 Val Lys Val Met Phe Asn Gly Lys Lys Leu Pro Val Asn Gly Phe Arg
         195                 200                 205            
 Ser Tyr Val Asp Leu Tyr Val Lys Asp Lys Leu Asp Glu Thr Gly Val
     210                 215                 220                
 Ala Leu Lys Val Ile His Glu Leu Ala Asn Glu Arg Trp Asp Val Cys
 225                 230                 235                 240
 Leu Thr Leu Ser Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser
                 245                 250                 255    
 Ile Ala Thr Thr Lys Gly Gly Arg His Val Asp Tyr Val Val Asp Gln
             260                 265                 270        
 Val Val Gly Lys Leu Ile Glu Val Val Lys Lys Lys Asn Lys Ala Gly
         275                 280                 285            
 Val Ser Val Lys Pro Phe Gln Val Lys Asn His Ile Trp Val Phe Ile
     290                 295                 300                
 Asn Cys Leu Ile Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn
 305                 310                 315                 320
 Met Thr Leu Gln Pro Lys Ser Phe Gly Ser Lys Cys Gln Leu Ser Glu
                 325                 330                 335    
 Lys Phe Phe Lys Ala Ala Ser Asn Cys Gly Ile Val Glu Ser Ile Leu
             340                 345                 350        
 Asn Trp Val Lys Phe Lys Ala Gln Thr Gln Leu Asn Lys Lys Cys Ser
         355                 360                 365            
 Ser Val Lys Tyr Ser Lys Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala
     370                 375                 380                
 Asn Asp Ala Gly Gly Lys His Ser Leu Glu Cys Thr Leu Ile Leu Thr
 385                 390                 395                 400
 Glu Gly Asp Ser Ala Lys Ser Leu Ala Val Ser Gly Leu Gly Val Ile
                 405                 410                 415    
 Gly Arg Asp Arg Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn
             420                 425                 430        
 Val Arg Glu Ala Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile Asn
         435                 440                 445            
 Asn Ile Ile Lys Ile Val Gly Leu Gln Tyr Lys Lys Ser Tyr Asp Asp
     450                 455                 460                
 Ala Glu Ser Leu Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met Thr
 465                 470                 475                 480
 Asp Gln Asp Gln Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn Phe
                 485                 490                 495    
 Ile His His Asn Trp Pro Ser Leu Leu Lys His Gly Phe Leu Glu Glu
             500                 505                 510        
 Phe Ile Thr Pro Ile Val Lys Ala Ser Lys Asn Lys Gln Glu Leu Ser
         515                 520                 525            
 Phe Tyr Ser Ile Pro Glu Phe Asp Glu Trp Lys Lys His Ile Glu Asn
     530                 535                 540                
 Gln Lys Ala Trp Lys Ile Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr
 545                 550                 555                 560
 Ala Lys Glu Ala Lys Glu Tyr Phe Ala Asp Met Glu Arg His Arg Ile
                 565                 570                 575    
 Leu Phe Arg Tyr Ala Gly Pro Glu Asp Asp Ala Ala Ile Thr Leu Ala
             580                 585                 590        
 Phe Ser Lys Lys Lys Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe
         595                 600                 605            
 Met Glu Asp Arg Arg Gln Arg Arg Leu His Gly Leu Pro Glu Gln Phe
     610                 615                 620                
 Leu Tyr Gly Thr Ala Thr Lys His Leu Thr Tyr Asn Asp Phe Ile Asn
 625                 630                 635                 640
 Lys Glu Leu Ile Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro
                 645                 650                 655    
 Ser Leu Val Asp Gly Phe Lys Pro Gly Gln Arg Lys Val Leu Phe Thr
             660                 665                 670        
 Cys Phe Lys Arg Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu Ala
         675                 680                 685            
 Gly Ser Val Ala Glu Met Ser Ala Tyr His His Gly Glu Gln Ala Leu
     690                 695                 700                
 Met Met Thr Ile Val Asn Leu Ala Gln Asn Phe Val Gly Ser Asn Asn
 705                 710                 715                 720
 Ile Asn Leu Leu Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His Gly
                 725                 730                 735    
 Gly Lys Asp Ala Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser Thr
             740                 745                 750        
 Leu Ala Arg Leu Leu Phe Pro Ala Val Asp Asp Asn Leu Leu Lys Phe
         755                 760                 765            
 Leu Tyr Asp Asp Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile
     770                 775                 780                
 Ile Pro Met Val Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp
 785                 790                 795                 800
 Ala Cys Lys Leu Pro Asn Tyr Asp Ala Arg Glu Ile Val Asn Asn Val
                 805                 810                 815    
 Arg Arg Met Leu Asp Gly Leu Asp Pro His Pro Met Leu Pro Asn Tyr
             820                 825                 830        
 Lys Asn Phe Lys Gly Thr Ile Gln Glu Leu Gly Gln Asn Gln Tyr Ala
         835                 840                 845            
 Val Ser Gly Glu Ile Phe Val Val Asp Arg Asn Thr Val Glu Ile Thr
     850                 855                 860                
 Glu Leu Pro Val Arg Thr Trp Thr Gln Val Tyr Lys Glu Gln Val Leu
 865                 870                 875                 880
 Glu Pro Met Leu Asn Gly Thr Asp Lys Thr Pro Ala Leu Ile Ser Asp
                 885                 890                 895    
 Tyr Lys Glu Tyr His Thr Asp Thr Thr Val Lys Phe Val Val Lys Met
             900                 905                 910        
 Thr Glu Glu Lys Leu Ala Gln Ala Glu Ala Ala Gly Leu His Lys Val
         915                 920                 925            
 Phe Lys Leu Gln Thr Thr Leu Thr Cys Asn Ser Met Val Leu Phe Asp
     930                 935                 940                
 His Met Gly Cys Leu Lys Lys Tyr Glu Thr Val Gln Asp Ile Leu Lys
 945                 950                 955                 960
 Glu Phe Phe Asp Leu Arg Leu Ser Tyr Tyr Gly Leu Arg Lys Glu Trp
                 965                 970                 975    
 Leu Val Gly Met Leu Gly Ala Glu Ser Thr Lys Leu Asn Asn Gln Ala
             980                 985                 990        
 Arg Phe Ile Leu Glu Lys Ile Gln Gly Lys Ile Thr Ile Glu Asn Arg
         995                1000                1005            
 Ser Lys Lys Asp Leu Ile Gln Met Leu Val Gln Arg Gly Tyr Glu Ser
    1010                1015                1020                
 Asp Pro Val Lys Ala Trp Lys Glu Ala Gln Glu Lys Ala Ala Glu Glu
1025                1030                1035                1040
 Asp Glu Thr Gln Asn Gln His Asp Asp Ser Ser Ser Asp Ser Gly Thr
                1045                1050                1055    
 Pro Ser Gly Pro Asp Phe Asn Tyr Ile Leu Asn Met Ser Leu Trp Ser
            1060                1065                1070        
 Leu Thr Lys Glu Lys Val Glu Glu Leu Ile Lys Gln Arg Asp Ala Lys
        1075                1080                1085            
 Gly Arg Glu Val Asn Asp Leu Lys Arg Lys Ser Pro Ser Asp Leu Trp
    1090                1095                1100                
 Lys Glu Asp Leu Ala Ala Phe Val Glu Glu Leu Asp Lys Val Glu Ser
1105                1110                1115                1120
 Gln Glu Arg Glu Asp Val Leu Ala Gly Met Ser Gly Lys Ala Ile Lys
                1125                1130                1135    
 Gly Lys Val Gly Lys Pro Lys Val Lys Lys Leu Gln Leu Glu Glu Thr
            1140                1145                1150        
 Met Pro Ser Pro Tyr Gly Arg Arg Ile Ile Pro Glu Ile Thr Ala Met
        1155                1160                1165            
 Lys Ala Asp Ala Ser Lys Lys Leu Leu Lys Lys Lys Lys Gly Asp Leu
    1170                1175                1180                
 Asp Thr Ala Ala Val Lys Val Glu Phe Asp Glu Glu Phe Ser Gly Ala
1185                1190                1195                1200
 Pro Val Glu Gly Ala Gly Glu Glu Ala Leu Thr Pro Ser Val Pro Ile
                1205                1210                1215    
 Asn Lys Gly Pro Lys Pro Lys Arg Glu Lys Lys Glu Pro Gly Thr Arg
            1220                1225                1230        
 Val Arg Lys Thr Pro Thr Ser Ser Gly Lys Pro Ser Ala Lys Lys Val
        1235                1240                1245            
 Lys Lys Arg Asn Pro Trp Ser Asp Asp Glu Ser Lys Ser Glu Ser Asp
    1250                1255                1260                
 Leu Glu Glu Thr Glu Pro Val Val Ile Pro Arg Asp Ser Leu Leu Arg
1265                1270                1275                1280
 Arg Ala Ala Ala Glu Arg Pro Lys Tyr Thr Phe Asp Phe Ser Glu Glu
                1285                1290                1295    
 Glu Asp Asp Asp Ala Asp Asp Asp Asp Asp Asp Asn Asn Asp Leu Glu
            1300                1305                1310        
 Glu Leu Lys Val Lys Ala Ser Pro Ile Thr Asn Asp Gly Glu Asp Glu
        1315                1320                1325            
 Phe Val Pro Ser Asp Gly Leu Asp Lys Asp Glu Tyr Thr Phe Ser Pro
    1330                1335                1340                
 Gly Lys Ser Lys Ala Thr Pro Glu Lys Ser Leu His Asp Lys Lys Ser
1345                1350                1355                1360
 Gln Asp Phe Gly Asn Leu Phe Ser Phe Pro Ser Tyr Ser Gln Lys Ser
                1365                1370                1375    
 Glu Asp Asp Ser Ala Lys Phe Asp Ser Asn Glu Glu Asp Ser Ala Ser
            1380                1385                1390        
 Val Phe Ser Pro Ser Phe Gly Leu Lys Gln Thr Asp Lys Val Pro Ser
        1395                1400                1405            
 Lys Thr Val Ala Ala Lys Lys Gly Lys Pro Ser Ser Asp Thr Val Pro
    1410                1415                1420                
 Lys Pro Lys Arg Ala Pro Lys Gln Lys Lys Val Val Glu Ala Val Asn
1425                1430                1435                1440
 Ser Asp Ser Asp Ser Glu Phe Gly Ile Pro Lys Lys Thr Thr Thr Pro
                1445                1450                1455    
 Lys Gly Lys Gly Arg Gly Ala Lys Lys Arg Lys Ala Ser Gly Ser Glu
            1460                1465                1470        
 Asn Glu Gly Asp Tyr Asn Pro Gly Arg Lys Thr Ser Lys Thr Thr Ser
        1475                1480                1485            
 Lys Lys Pro Lys Lys Thr Ser Phe Asp Gln Asp Ser Asp Val Asp Ile
    1490                1495                1500                
 Phe Pro Ser Asp Phe Pro Thr Glu Pro Pro Ser Leu Pro Arg Thr Gly
1505                1510                1515                1520
 Arg Ala Arg Lys Glu Val Lys Tyr Phe Ala Glu Ser Asp Glu Glu Glu
                1525                1530                1535    
 Asp Asp Val Asp Phe Ala Met Phe Asn
            1540                1545



      <210> 1226
      <211> 658
      <212> PRT
      <213> Homo sapiens


      <400> 1226
 Met Arg Ala Pro Gly Ala Gly Ala Ala Ser Val Val Ser Leu Ala Leu
   1               5                  10                  15    
 Leu Trp Leu Leu Gly Leu Pro Trp Thr Trp Ser Ala Ala Ala Ala Leu
              20                  25                  30        
 Gly Val Tyr Val Gly Ser Gly Gly Trp Arg Phe Leu Arg Ile Val Cys
          35                  40                  45            
 Lys Thr Ala Arg Arg Asp Leu Phe Gly Leu Ser Val Leu Ile Arg Val
      50                  55                  60                
 Arg Leu Glu Leu Arg Arg His Gln Arg Ala Gly His Thr Ile Pro Arg
  65                  70                  75                  80
 Ile Phe Gln Ala Val Val Gln Arg Gln Pro Glu Arg Leu Ala Leu Val
                  85                  90                  95    
 Asp Ala Gly Thr Gly Glu Cys Trp Thr Phe Ala Gln Leu Asp Ala Tyr
             100                 105                 110        
 Ser Asn Ala Val Ala Asn Leu Phe Arg Gln Leu Gly Phe Ala Pro Gly
         115                 120                 125            
 Asp Val Val Ala Ile Phe Leu Glu Gly Arg Pro Glu Phe Val Gly Leu
     130                 135                 140                
 Trp Leu Gly Leu Ala Lys Ala Gly Met Glu Ala Ala Leu Leu Asn Val
 145                 150                 155                 160
 Asn Leu Arg Arg Glu Pro Leu Ala Phe Cys Leu Gly Thr Ser Gly Ala
                 165                 170                 175    
 Lys Ala Leu Ile Phe Gly Gly Glu Met Val Ala Ala Val Ala Glu Val
             180                 185                 190        
 Ser Gly His Leu Gly Lys Ser Leu Ile Lys Phe Cys Ser Gly Asp Leu
         195                 200                 205            
 Gly Pro Glu Gly Ile Leu Pro Asp Thr His Leu Leu Asp Pro Leu Leu
     210                 215                 220                
 Lys Glu Ala Ser Thr Ala Pro Leu Ala Gln Ile Pro Ser Lys Gly Met
 225                 230                 235                 240
 Asp Asp Arg Leu Phe Tyr Ile Tyr Thr Ser Gly Thr Thr Gly Leu Pro
                 245                 250                 255    
 Lys Ala Ala Ile Val Val His Ser Arg Tyr Tyr Arg Met Ala Ala Phe
             260                 265                 270        
 Gly His His Ala Tyr Arg Met Gln Ala Ala Asp Val Leu Tyr Asp Cys
         275                 280                 285            
 Leu Pro Leu Tyr His Ser Ala Gly Asn Ile Ile Gly Val Gly Gln Cys
     290                 295                 300                
 Leu Ile Tyr Gly Leu Thr Val Val Leu Arg Lys Lys Phe Ser Ala Ser
 305                 310                 315                 320
 Arg Phe Trp Asp Asp Cys Ile Lys Tyr Asn Cys Thr Val Val Gln Tyr
                 325                 330                 335    
 Ile Gly Glu Ile Cys Arg Tyr Leu Leu Lys Gln Pro Val Arg Glu Ala
             340                 345                 350        
 Glu Arg Arg His Arg Val Arg Leu Ala Val Gly Asn Gly Leu Arg Pro
         355                 360                 365            
 Ala Ile Trp Glu Glu Phe Thr Glu Arg Phe Gly Val Arg Gln Ile Gly
     370                 375                 380                
 Glu Phe Tyr Gly Ala Thr Glu Cys Asn Cys Ser Ile Ala Asn Met Asp
 385                 390                 395                 400
 Gly Lys Val Gly Ser Cys Gly Phe Asn Ser Arg Ile Leu Pro His Val
                 405                 410                 415    
 Tyr Pro Ile Arg Leu Val Lys Val Asn Glu Asp Thr Met Glu Leu Leu
             420                 425                 430        
 Arg Asp Ala Gln Gly Leu Cys Ile Pro Cys Gln Ala Gly Glu Pro Gly
         435                 440                 445            
 Leu Leu Val Gly Gln Ile Asn Gln Gln Asp Pro Leu Arg Arg Phe Asp
     450                 455                 460                
 Gly Tyr Val Ser Glu Ser Ala Thr Ser Lys Lys Ile Ala His Ser Val
 465                 470                 475                 480
 Phe Ser Lys Gly Asp Ser Ala Tyr Leu Ser Gly Asp Val Leu Val Met
                 485                 490                 495    
 Asp Glu Leu Gly Tyr Met Tyr Phe Arg Asp Arg Ser Gly Asp Thr Phe
             500                 505                 510        
 Arg Trp Arg Gly Glu Asn Val Ser Thr Thr Glu Val Glu Gly Val Leu
         515                 520                 525            
 Ser Arg Leu Leu Gly Gln Thr Asp Val Ala Val Tyr Gly Val Ala Val
     530                 535                 540                
 Pro Gly Lys Leu Gly Leu Gln Gly Val Val Leu Arg His Gly Val Glu
 545                 550                 555                 560
 Gly Lys Ala Gly Met Ala Ala Val Ala Asp Pro His Ser Leu Leu Asp
                 565                 570                 575    
 Pro Asn Ala Ile Tyr Gln Glu Leu Gln Lys Val Leu Ala Pro Tyr Ala
             580                 585                 590        
 Arg Pro Ile Phe Leu Arg Leu Leu Pro Gln Val Asp Thr Thr Gly Thr
         595                 600                 605            
 Phe Lys Ile Gln Lys Thr Arg Leu Gln Arg Glu Gly Phe Asp Pro Arg
     610                 615                 620                
 Gln Thr Ser Asp Arg Leu Phe Phe Leu Asp Leu Lys Gln Gly His Tyr
 625                 630                 635                 640
 Leu Pro Leu Asn Glu Ala Val Tyr Thr Arg Ile Cys Ser Gly Ala Phe
                 645                 650                 655    
 Ala Leu
        



      <210> 1227
      <211> 209
      <212> PRT
      <213> Homo sapiens


      <400> 1227
 Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile
   1               5                  10                  15    
 Leu Leu Ala Lys Gly Thr Ser Gly Ser Ala Leu Thr Ala Leu Ile Ser
              20                  25                  30        
 Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu
          35                  40                  45            
 Leu Ala Asn Val Gln Glu Cys Ile Pro Tyr Ser Val Leu Leu Lys Asp
      50                  55                  60                
 Leu Glu Met Arg Asn Leu Arg Glu Leu Glu Asp Leu Ile Ile Glu Ala
  65                  70                  75                  80
 Val Tyr Thr Asp Ile Ile Gln Gly Lys Leu Asp Gln Arg Asn Gln Leu
                  85                  90                  95    
 Leu Glu Val Asp Phe Cys Ile Gly Arg Asp Ile Arg Lys Lys Asp Ile
             100                 105                 110        
 Asn Asn Ile Val Lys Thr Leu His Glu Trp Cys Asp Gly Cys Glu Ala
         115                 120                 125            
 Val Leu Leu Gly Ile Glu Gln Gln Val Leu Arg Ala Asn Gln Tyr Lys
     130                 135                 140                
 Glu Asn His Asn Arg Thr Gln Gln Gln Val Glu Ala Glu Val Thr Asn
 145                 150                 155                 160
 Ile Lys Lys Thr Leu Lys Ala Thr Ala Ser Ser Ser Ala Gln Glu Met
                 165                 170                 175    
 Glu Gln Gln Leu Ala Glu Arg Glu Cys Pro Pro His Ala Glu Gln Arg
             180                 185                 190        
 Gln Pro Thr Lys Lys Met Ser Lys Val Lys Gly Leu Val Ser Ser Arg
         195                 200                 205            
 His
    



      <210> 1228
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 1228
 Met Leu Gly Ala Lys Pro His Trp Leu Pro Gly Pro Leu His Ser Pro
   1               5                  10                  15    
 Gly Leu Pro Leu Val Leu Val Leu Leu Ala Leu Gly Ala Gly Trp Ala
              20                  25                  30        
 Gln Glu Gly Ser Glu Pro Val Leu Leu Glu Gly Glu Cys Leu Val Val
          35                  40                  45            
 Cys Glu Pro Gly Arg Ala Ala Ala Gly Gly Pro Gly Gly Ala Ala Leu
      50                  55                  60                
 Gly Glu Ala Pro Pro Gly Arg Val Ala Phe Ala Ala Val Arg Ser His
  65                  70                  75                  80
 His His Glu Pro Ala Gly Glu Thr Gly Asn Gly Thr Ser Gly Ala Ile
                  85                  90                  95    
 Tyr Phe Asp Gln Val Leu Val Asn Glu Gly Gly Gly Phe Asp Arg Ala
             100                 105                 110        
 Ser Gly Ser Phe Val Ala Pro Val Arg Gly Val Tyr Ser Phe Arg Phe
         115                 120                 125            
 His Val Val Lys Val Tyr Asn Arg Gln Thr Val Gln Val Ser Leu Val
     130                 135                 140                
 Leu Asn Thr Trp Pro Val Ile Ser Ala Phe Ala Asn Asp Pro Asp Val
 145                 150                 155                 160
 Thr Arg Glu Ala Ala Thr Ser Ser Val Leu Leu Pro Leu Asp Pro Gly
                 165                 170                 175    
 Asp Arg Val Ser Leu Arg Leu Arg Arg Gly Asn Leu Leu Gly Gly Trp
             180                 185                 190        
 Lys Tyr Ser Ser Phe Ser Gly Phe Leu Ile Phe Pro Leu
         195                 200                 205



      <210> 1229
      <211> 544
      <212> PRT
      <213> Homo sapiens


      <400> 1229
 Met Arg Glu Ser Gln Pro Glu Ala Glu Ile Pro Leu Gln Asp Thr Thr
   1               5                  10                  15    
 Ala Glu Ala Phe Thr Met Leu Leu Lys Tyr Ile Tyr Thr Gly Arg Ala
              20                  25                  30        
 Thr Leu Thr Asp Glu Lys Glu Glu Val Leu Leu Asp Phe Leu Ser Leu
          35                  40                  45            
 Ala His Lys Tyr Gly Phe Pro Glu Leu Glu Asp Ser Thr Ser Glu Tyr
      50                  55                  60                
 Leu Cys Thr Ile Leu Asn Ile Gln Asn Val Cys Met Thr Phe Asp Val
  65                  70                  75                  80
 Ala Ser Leu Tyr Ser Leu Pro Lys Leu Thr Cys Met Cys Cys Met Phe
                  85                  90                  95    
 Met Asp Arg Asn Ala Gln Glu Val Leu Ser Ser Glu Gly Phe Leu Ser
             100                 105                 110        
 Leu Ser Lys Thr Ala Leu Leu Asn Ile Val Leu Arg Asp Ser Phe Ala
         115                 120                 125            
 Ala Pro Glu Lys Asp Ile Phe Leu Ala Leu Leu Asn Trp Cys Lys His
     130                 135                 140                
 Asn Ser Lys Glu Asn His Ala Glu Ile Met Gln Ala Val Arg Leu Pro
 145                 150                 155                 160
 Leu Met Ser Leu Thr Glu Leu Leu Asn Val Val Arg Pro Ser Gly Leu
                 165                 170                 175    
 Leu Ser Pro Asp Ala Ile Leu Asp Ala Ile Lys Val Arg Ser Glu Ser
             180                 185                 190        
 Arg Asp Met Asp Leu Asn Tyr Arg Gly Met Leu Ile Pro Glu Glu Asn
         195                 200                 205            
 Ile Ala Thr Met Lys Tyr Gly Ala Gln Val Val Lys Gly Glu Leu Lys
     210                 215                 220                
 Ser Ala Leu Leu Asp Gly Asp Thr Gln Asn Tyr Asp Leu Asp His Gly
 225                 230                 235                 240
 Phe Ser Arg His Pro Ile Asp Asp Asp Cys Arg Ser Gly Ile Glu Ile
                 245                 250                 255    
 Lys Leu Gly Gln Pro Ser Ile Ile Asn His Val Arg Ile Leu Leu Trp
             260                 265                 270        
 Asp Arg Asp Ser Arg Ser Tyr Ser Tyr Phe Ile Glu Val Ser Met Asp
         275                 280                 285            
 Glu Leu Asp Trp Val Arg Val Ile Asp His Ser Gln Tyr Leu Cys Arg
     290                 295                 300                
 Ser Trp Gln Lys Leu Tyr Phe Pro Ala Arg Val Cys Arg Tyr Ile Arg
 305                 310                 315                 320
 Ile Val Gly Thr His Asn Thr Val Asn Lys Ile Phe His Ile Val Ala
                 325                 330                 335    
 Phe Glu Cys Met Phe Thr Asn Lys Thr Phe Thr Leu Glu Lys Gly Leu
             340                 345                 350        
 Ile Val Pro Met Glu Asn Val Ala Thr Ile Ala Asp Cys Ala Ser Val
         355                 360                 365            
 Ile Glu Gly Val Ser Arg Ser Arg Asn Ala Leu Leu Asn Gly Asp Thr
     370                 375                 380                
 Lys Asn Tyr Asp Trp Asp Ser Gly Tyr Thr Cys His Gln Leu Gly Ser
 385                 390                 395                 400
 Gly Ala Ile Val Val Gln Leu Ala Gln Pro Tyr Met Ile Gly Ser Ile
                 405                 410                 415    
 Arg Leu Leu Leu Trp Asp Cys Asp Asp Arg Ser Tyr Ser Tyr Tyr Val
             420                 425                 430        
 Glu Val Ser Thr Asn Gln Gln Gln Trp Thr Met Val Ala Asp Arg Thr
         435                 440                 445            
 Lys Val Ser Cys Lys Ser Trp Gln Ser Val Thr Phe Glu Arg Gln Pro
     450                 455                 460                
 Ala Ser Phe Ile Arg Ile Val Gly Thr His Asn Thr Ala Asn Glu Val
 465                 470                 475                 480
 Phe His Cys Val His Phe Glu Cys Pro Glu Gln Gln Ser Ser Gln Lys
                 485                 490                 495    
 Glu Glu Asn Ser Glu Glu Ser Gly Thr Gly Asp Thr Ser Leu Ala Gly
             500                 505                 510        
 Gln Gln Leu Asp Ser His Ala Leu Arg Ala Pro Ser Gly Ser Ser Leu
         515                 520                 525            
 Pro Ser Ser Pro Gly Ser Asn Ser Arg Ser Pro Asn Arg Gln His Gln
     530                 535                 540                





      <210> 1230
      <211> 1118
      <212> PRT
      <213> Homo sapiens


      <400> 1230
 Met Gly Ile Leu Ser Ile Thr Asp Gln Pro Pro Leu Val Gln Ala Ile
   1               5                  10                  15    
 Phe Ser Arg Asp Val Glu Glu Val Arg Ser Leu Leu Ser Gln Lys Glu
              20                  25                  30        
 Asn Ile Asn Val Leu Asp Gln Glu Arg Arg Thr Pro Leu His Ala Ala
          35                  40                  45            
 Ala Tyr Val Gly Asp Val Pro Ile Leu Gln Leu Leu Leu Met Ser Gly
      50                  55                  60                
 Glu Ser Gly Glu Leu Glu Gly Asn Tyr Ile Pro Thr Gly Ala Asn Val
  65                  70                  75                  80
 Asn Ala Lys Asp Thr Leu Trp Leu Thr Pro Leu His Arg Ala Ala Ala
                  85                  90                  95    
 Ser Arg Asn Glu Val Cys Thr Pro Thr Phe Tyr Tyr Pro Phe Lys Lys
             100                 105                 110        
 Asp Lys Leu Leu Lys Ala Pro Gly Gly Gly Ala Glu Ala Ser Gly Asn
         115                 120                 125            
 Glu Lys Val Leu Gly Leu Leu Leu Ala His Ser Ala Asp Val Asn Ala
     130                 135                 140                
 Arg Asp Lys Leu Trp Gln Thr Pro Leu His Val Ala Ala Ala Asn Arg
 145                 150                 155                 160
 Ala Thr Lys Cys Ala Glu Ala Leu Ala Pro Leu Leu Ser Ser Leu Asn
                 165                 170                 175    
 Val Ala Asp Arg Ser Gly Arg Ser Ala Leu His His Ala Val His Ser
             180                 185                 190        
 Gly His Leu Glu Thr Val Asn Leu Leu Leu Asn Lys Gly Ala Ser Leu
         195                 200                 205            
 Asn Val Cys Asp Lys Lys Glu Arg Gln Pro Leu His Trp Ala Ala Phe
     210                 215                 220                
 Leu Gly His Leu Glu Val Leu Lys Leu Leu Val Ala Arg Gly Ala Asp
 225                 230                 235                 240
 Leu Gly Cys Lys Asp Arg Lys Gly Tyr Gly Leu Leu His Thr Ala Ala
                 245                 250                 255    
 Ala Ser Gly Gln Ile Glu Val Val Lys Tyr Leu Leu Arg Met Gly Ala
             260                 265                 270        
 Glu Ile Asp Glu Pro Asn Ala Phe Gly Asn Thr Ala Leu His Ile Ala
         275                 280                 285            
 Cys Tyr Leu Gly Gln Asp Ala Val Ala Ile Glu Leu Val Asn Ala Gly
     290                 295                 300                
 Ala Asn Val Asn Gln Pro Asn Asp Lys Gly Phe Thr Pro Leu His Val
 305                 310                 315                 320
 Ala Ala Val Ser Thr Asn Val Ala Leu Cys Leu Glu Leu Leu Val Asn
                 325                 330                 335    
 Asn Gly Ala Asp Val Asn Tyr Gln Ser Lys Glu Gly Lys Ser Pro Leu
             340                 345                 350        
 His Met Ala Ala Ile His Gly Arg Phe Thr Arg Ser Gln Ile Leu Ile
         355                 360                 365            
 Gln Asn Gly Ser Glu Ile Asp Cys Ala Asp Lys Phe Gly Asn Thr Pro
     370                 375                 380                
 Leu His Val Ala Ala Arg Tyr Gly His Glu Leu Leu Ile Ser Thr Leu
 385                 390                 395                 400
 Met Thr Asn Gly Ala Asp Thr Ala Arg Arg Gly Ile His Asp Met Phe
                 405                 410                 415    
 Pro Leu His Leu Ala Val Leu Phe Gly Phe Ser Asp Cys Cys Arg Lys
             420                 425                 430        
 Leu Leu Ser Ser Gly Gln Leu Tyr Ser Ile Val Ser Ser Leu Ser Asn
         435                 440                 445            
 Glu His Val Leu Ser Ala Gly Phe Asp Ile Asn Thr Pro Asp Asn Leu
     450                 455                 460                
 Gly Arg Thr Cys Leu His Ala Ala Ala Ser Gly Gly Asn Val Glu Cys
 465                 470                 475                 480
 Leu Asn Leu Leu Leu Ser Ser Gly Ala Asp Leu Arg Arg Arg Asp Lys
                 485                 490                 495    
 Phe Gly Arg Thr Pro Leu His Tyr Ala Ala Ala Asn Gly Ser Tyr Gln
             500                 505                 510        
 Cys Ala Val Thr Leu Val Thr Ala Gly Ala Gly Val Asn Glu Ala Asp
         515                 520                 525            
 Cys Lys Gly Cys Ser Pro Leu His Tyr Ala Ala Ala Ser Asp Thr Tyr
     530                 535                 540                
 Arg Arg Ala Glu Pro His Thr Pro Ser Ser His Asp Ala Glu Glu Asp
 545                 550                 555                 560
 Glu Pro Leu Lys Glu Ser Arg Arg Lys Glu Ala Phe Phe Cys Leu Glu
                 565                 570                 575    
 Phe Leu Leu Asp Asn Gly Ala Asp Pro Ser Leu Arg Asp Arg Gln Gly
             580                 585                 590        
 Tyr Thr Ala Val His Tyr Ala Ala Ala Tyr Gly Asn Arg Gln Asn Leu
         595                 600                 605            
 Glu Leu Leu Leu Glu Met Ser Phe Asn Cys Leu Glu Asp Val Glu Ser
     610                 615                 620                
 Thr Ile Pro Val Ser Pro Leu His Leu Ala Ala Tyr Asn Gly His Cys
 625                 630                 635                 640
 Glu Ala Leu Lys Thr Leu Ala Glu Thr Leu Val Asn Leu Asp Val Arg
                 645                 650                 655    
 Asp His Lys Gly Arg Thr Ala Leu Phe Leu Ala Thr Glu Arg Gly Ser
             660                 665                 670        
 Thr Glu Cys Val Glu Val Leu Thr Ala His Gly Ala Ser Ala Leu Ile
         675                 680                 685            
 Lys Glu Arg Lys Arg Lys Trp Thr Pro Leu His Ala Ala Ala Ala Ser
     690                 695                 700                
 Gly His Thr Asp Ser Leu His Leu Leu Ile Asp Ser Gly Glu Arg Ala
 705                 710                 715                 720
 Asp Ile Thr Asp Val Met Asp Ala Tyr Gly Gln Thr Pro Leu Met Leu
                 725                 730                 735    
 Ala Ile Met Asn Gly His Val Asp Cys Val His Leu Leu Leu Glu Lys
             740                 745                 750        
 Gly Ser Thr Ala Asp Ala Ala Asp Leu Arg Gly Arg Thr Ala Leu His
         755                 760                 765            
 Arg Gly Ala Val Thr Gly Cys Glu Asp Cys Leu Ala Ala Leu Leu Asp
     770                 775                 780                
 His Asp Ala Phe Val Leu Cys Arg Asp Phe Lys Gly Arg Thr Pro Ile
 785                 790                 795                 800
 His Leu Ala Ser Ala Cys Gly His Thr Ala Val Leu Arg Thr Leu Leu
                 805                 810                 815    
 Gln Ala Ala Leu Ser Thr Asp Pro Leu Asp Ala Gly Val Asp Tyr Ser
             820                 825                 830        
 Gly Tyr Ser Pro Met His Trp Ala Ser Tyr Thr Gly His Glu Asp Cys
         835                 840                 845            
 Leu Glu Leu Leu Leu Glu His Ser Pro Phe Ser Tyr Leu Glu Gly Asn
     850                 855                 860                
 Pro Phe Thr Pro Leu His Cys Ala Val Ile Asn Asn Gln Asp Ser Thr
 865                 870                 875                 880
 Thr Glu Met Leu Leu Gly Ala Leu Gly Ala Lys Ile Val Asn Ser Arg
                 885                 890                 895    
 Asp Ala Lys Gly Arg Thr Pro Leu His Ala Ala Ala Phe Ala Asp Asn
             900                 905                 910        
 Val Ser Gly Leu Arg Met Leu Leu Gln His Gln Ala Glu Val Asn Ala
         915                 920                 925            
 Thr Asp His Thr Gly Arg Thr Ala Leu Met Thr Ala Ala Glu Asn Gly
     930                 935                 940                
 Gln Thr Ala Ala Val Glu Phe Leu Leu Tyr Arg Gly Lys Ala Asp Leu
 945                 950                 955                 960
 Thr Val Leu Asp Glu Asn Lys Asn Thr Ala Leu His Leu Ala Cys Ser
                 965                 970                 975    
 Lys Gly His Glu Lys Cys Ala Leu Met Ile Leu Ala Glu Thr Gln Asp
             980                 985                 990        
 Leu Gly Leu Ile Asn Ala Thr Asn Ser Ala Leu Gln Met Pro Leu His
         995                1000                1005            
 Ile Ala Ala Arg Asn Gly Leu Ala Ser Val Val Gln Ala Leu Leu Ser
    1010                1015                1020                
 His Gly Ala Thr Val Leu Ala Val Asp Glu Glu Gly His Thr Pro Ala
1025                1030                1035                1040
 Leu Ala Cys Ala Pro Asn Lys Asp Val Ala Asp Cys Leu Ala Leu Ile
                1045                1050                1055    
 Leu Ser Thr Met Lys Pro Phe Pro Pro Lys Asp Ala Val Ser Pro Phe
            1060                1065                1070        
 Ser Phe Ser Leu Leu Lys Asn Cys Ser Ile Ala Ala Ala Lys Thr Val
        1075                1080                1085            
 Gly Gly Cys Gly Ala Leu Pro His Gly Ala Ser Cys Pro Tyr Ser Gln
    1090                1095                1100                
 Glu Arg Pro Gly Ala Ile Gly Leu Asp Gly Cys Tyr Ser Glu
1105                1110                1115            



      <210> 1231
      <211> 476
      <212> PRT
      <213> Homo sapiens


      <400> 1231
 Met Cys Thr Lys Thr Ile Pro Val Leu Trp Gly Cys Phe Leu Leu Trp
   1               5                  10                  15    
 Asn Leu Tyr Val Ser Ser Ser Gln Thr Ile Tyr Pro Gly Ile Lys Ala
              20                  25                  30        
 Arg Ile Thr Gln Arg Ala Leu Asp Tyr Gly Val Gln Ala Gly Met Lys
          35                  40                  45            
 Met Ile Glu Gln Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly
      50                  55                  60                
 Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe
  65                  70                  75                  80
 Ser Asn Ile Lys Ile Ser Ala Phe Ser Phe Pro Asn Thr Ser Leu Ala
                  85                  90                  95    
 Phe Val Pro Gly Val Gly Ile Lys Ala Leu Thr Asn His Gly Thr Ala
             100                 105                 110        
 Asn Ile Ser Thr Asp Trp Gly Phe Glu Ser Pro Leu Phe Gln Asp Thr
         115                 120                 125            
 Gly Gly Ala Asp Leu Phe Leu Ser Gly Val Tyr Phe Thr Gly Ile Ile
     130                 135                 140                
 Ile Leu Thr Arg Asn Asp Phe Gly His Pro Thr Leu Lys Leu Gln Asp
 145                 150                 155                 160
 Cys Tyr Ala Gln Leu Ser His Ala His Val Ser Phe Ser Gly Glu Leu
                 165                 170                 175    
 Ser Val Leu Tyr Asn Ser Phe Ala Glu Pro Met Glu Lys Pro Ile Leu
             180                 185                 190        
 Lys Asn Leu Asn Glu Met Leu Cys Pro Ile Ile Ala Ser Glu Val Lys
         195                 200                 205            
 Ala Leu Asn Ala Asn Leu Ser Thr Leu Glu Val Leu Thr Lys Ile Asp
     210                 215                 220                
 Asn Tyr Thr Leu Leu Asp Tyr Ser Leu Ile Ser Ser Pro Glu Ile Thr
 225                 230                 235                 240
 Glu Asn Tyr Leu Asp Leu Asn Leu Lys Gly Val Phe Tyr Pro Leu Glu
                 245                 250                 255    
 Asn Leu Thr Asp Pro Pro Phe Ser Pro Val Pro Phe Val Leu Pro Glu
             260                 265                 270        
 Arg Ser Asn Ser Met Leu Tyr Ile Gly Ile Ala Glu Tyr Phe Phe Lys
         275                 280                 285            
 Ser Ala Ser Phe Ala His Phe Thr Ala Gly Val Phe Asn Val Thr Leu
     290                 295                 300                
 Ser Thr Glu Glu Ile Ser Asn His Phe Val Gln Asn Ser Gln Gly Leu
 305                 310                 315                 320
 Gly Asn Val Leu Ser Arg Ile Ala Glu Ile Tyr Ile Leu Ser Gln Pro
                 325                 330                 335    
 Phe Met Val Arg Ile Met Ala Thr Glu Pro Pro Ile Ile Asn Leu Gln
             340                 345                 350        
 Pro Gly Asn Phe Thr Leu Asp Ile Pro Ala Ser Ile Met Met Leu Thr
         355                 360                 365            
 Gln Pro Lys Asn Ser Thr Val Glu Thr Ile Val Ser Met Asp Phe Val
     370                 375                 380                
 Ala Ser Thr Ser Val Gly Leu Val Ile Leu Gly Gln Arg Leu Val Cys
 385                 390                 395                 400
 Ser Leu Ser Leu Asn Arg Phe Arg Leu Ala Leu Pro Glu Ser Asn Arg
                 405                 410                 415    
 Ser Asn Ile Glu Val Leu Arg Phe Glu Asn Ile Leu Ser Ser Ile Leu
             420                 425                 430        
 His Phe Gly Val Leu Pro Leu Ala Asn Ala Lys Leu Gln Gln Gly Phe
         435                 440                 445            
 Pro Leu Pro Asn Pro His Lys Phe Leu Phe Val Asn Ser Asp Ile Glu
     450                 455                 460                
 Val Leu Glu Val Arg Met Gln Ile Ser Pro Leu Asn
 465                 470                 475    



      <210> 1232
      <211> 476
      <212> PRT
      <213> Homo sapiens


      <400> 1232
 Met Cys Thr Lys Thr Ile Pro Val Leu Trp Gly Cys Phe Leu Leu Trp
   1               5                  10                  15    
 Asn Leu Tyr Val Ser Ser Ser Gln Thr Ile Tyr Pro Gly Ile Lys Ala
              20                  25                  30        
 Arg Ile Thr Gln Arg Ala Leu Asp Tyr Gly Val Gln Ala Gly Met Lys
          35                  40                  45            
 Met Ile Glu Gln Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly
      50                  55                  60                
 Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe
  65                  70                  75                  80
 Ser Asn Ile Lys Ile Ser Ala Phe Ser Phe Pro Asn Thr Ser Leu Ala
                  85                  90                  95    
 Phe Val Pro Gly Val Gly Ile Lys Ala Leu Thr Asn His Gly Thr Ala
             100                 105                 110        
 Asn Ile Ser Thr Asp Trp Gly Phe Glu Ser Pro Leu Phe Gln Asp Thr
         115                 120                 125            
 Gly Gly Ala Asp Leu Phe Leu Ser Gly Val Tyr Phe Thr Gly Ile Ile
     130                 135                 140                
 Ile Leu Thr Arg Asn Asp Phe Gly His Pro Thr Leu Lys Leu Gln Asp
 145                 150                 155                 160
 Cys Tyr Ala Gln Leu Ser His Ala His Val Ser Phe Ser Gly Glu Leu
                 165                 170                 175    
 Ser Val Leu Tyr Asn Ser Phe Ala Glu Pro Met Glu Lys Pro Ile Leu
             180                 185                 190        
 Lys Asn Leu Asn Glu Met Leu Cys Pro Ile Ile Ala Ser Glu Val Lys
         195                 200                 205            
 Ala Leu Asn Ala Asn Leu Ser Thr Leu Glu Val Leu Thr Lys Ile Asp
     210                 215                 220                
 Asn Tyr Thr Leu Leu Asp Tyr Ser Leu Ile Ser Ser Pro Glu Ile Thr
 225                 230                 235                 240
 Glu Asn Tyr Leu Asp Leu Asn Leu Lys Gly Val Phe Tyr Pro Leu Glu
                 245                 250                 255    
 Asn Leu Thr Asp Pro Pro Phe Ser Pro Val Pro Phe Val Leu Pro Glu
             260                 265                 270        
 Arg Ser Asn Ser Met Leu Tyr Ile Gly Ile Ala Glu Tyr Phe Phe Lys
         275                 280                 285            
 Ser Ala Ser Phe Ala His Phe Thr Ala Gly Val Phe Asn Val Thr Leu
     290                 295                 300                
 Ser Thr Glu Glu Ile Ser Asn His Phe Val Gln Asn Ser Gln Gly Leu
 305                 310                 315                 320
 Gly Asn Val Leu Ser Arg Ile Ala Glu Ile Tyr Ile Leu Ser Gln Pro
                 325                 330                 335    
 Phe Met Val Arg Ile Met Ala Thr Glu Pro Pro Ile Ile Asn Leu Gln
             340                 345                 350        
 Pro Gly Asn Phe Thr Leu Asp Ile Pro Ala Ser Ile Met Met Leu Thr
         355                 360                 365            
 Gln Pro Lys Asn Ser Thr Val Glu Thr Ile Val Ser Met Asp Phe Val
     370                 375                 380                
 Ala Ser Thr Ser Val Gly Leu Val Ile Leu Gly Gln Arg Leu Val Cys
 385                 390                 395                 400
 Ser Leu Ser Leu Asn Arg Phe Arg Leu Ala Leu Pro Glu Ser Asn Arg
                 405                 410                 415    
 Ser Asn Ile Glu Val Leu Arg Phe Glu Asn Ile Leu Ser Ser Ile Leu
             420                 425                 430        
 His Phe Gly Val Leu Pro Leu Ala Asn Ala Lys Leu Gln Gln Gly Phe
         435                 440                 445            
 Pro Leu Ser Asn Pro His Lys Phe Leu Phe Val Asn Ser Asp Ile Glu
     450                 455                 460                
 Val Leu Glu Val Arg Met Gln Ile Ser Pro Leu Asn
 465                 470                 475    



      <210> 1233
      <211> 507
      <212> PRT
      <213> Homo sapiens


      <400> 1233
 Met Cys Thr Lys Thr Ile Pro Val Leu Trp Gly Cys Phe Leu Leu Trp
   1               5                  10                  15    
 Asn Leu Tyr Val Ser Ser Ser Gln Thr Ile Tyr Pro Gly Ile Lys Ala
              20                  25                  30        
 Arg Ile Thr Gln Arg Ala Leu Asp Tyr Gly Val Gln Ala Gly Met Lys
          35                  40                  45            
 Met Ile Glu Gln Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly
      50                  55                  60                
 Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe
  65                  70                  75                  80
 Ser Asn Ile Lys Ile Ser Ala Phe Ser Phe Pro Asn Thr Ser Leu Ala
                  85                  90                  95    
 Phe Val Pro Gly Val Gly Ile Lys Ala Leu Thr Asn His Gly Thr Ala
             100                 105                 110        
 Asn Ile Ser Thr Asp Trp Gly Phe Glu Ser Pro Leu Phe Gln Asp Thr
         115                 120                 125            
 Gly Gly Ala Asp Leu Phe Leu Ser Gly Val Tyr Phe Thr Gly Ile Ile
     130                 135                 140                
 Ile Leu Thr Arg Asn Asp Phe Gly His Pro Thr Leu Lys Leu Gln Asp
 145                 150                 155                 160
 Cys Tyr Ala Gln Leu Ser His Ala His Val Ser Phe Ser Gly Glu Leu
                 165                 170                 175    
 Ser Val Leu Tyr Asn Ser Phe Ala Glu Pro Met Glu Lys Pro Ile Leu
             180                 185                 190        
 Lys Asn Leu Asn Glu Met Leu Cys Pro Ile Ile Ala Ser Glu Val Lys
         195                 200                 205            
 Ala Leu Asn Ala Asn Leu Ser Thr Leu Glu Val Leu Thr Lys Ile Asp
     210                 215                 220                
 Asn Tyr Thr Leu Leu Asp Tyr Ser Leu Ile Ser Ser Pro Glu Ile Thr
 225                 230                 235                 240
 Glu Asn Tyr Leu Asp Leu Asn Leu Lys Gly Val Phe Tyr Pro Leu Glu
                 245                 250                 255    
 Asn Leu Thr Asp Pro Pro Phe Ser Pro Val Pro Phe Val Leu Pro Glu
             260                 265                 270        
 Arg Ser Asn Ser Met Leu Tyr Ile Gly Ile Ala Glu Tyr Phe Phe Lys
         275                 280                 285            
 Ser Ala Ser Phe Ala His Phe Thr Ala Gly Val Phe Asn Val Thr Leu
     290                 295                 300                
 Ser Thr Glu Glu Ile Ser Asn His Phe Val Gln Asn Ser Gln Gly Leu
 305                 310                 315                 320
 Gly Asn Val Leu Ser Arg Ile Ala Glu Ile Tyr Ile Leu Ser Gln Pro
                 325                 330                 335    
 Phe Met Val Arg Ile Met Ala Thr Glu Pro Pro Ile Ile Asn Leu Gln
             340                 345                 350        
 Pro Gly Asn Phe Thr Leu Asp Ile Pro Ala Ser Ile Met Met Leu Thr
         355                 360                 365            
 Gln Pro Lys Asn Ser Thr Val Glu Thr Ile Val Ser Met Asp Phe Val
     370                 375                 380                
 Ala Ser Thr Ser Val Gly Leu Val Ile Leu Gly Gln Arg Leu Val Cys
 385                 390                 395                 400
 Ser Leu Ser Leu Asn Arg Phe Arg Leu Ala Leu Pro Glu Ser Asn Arg
                 405                 410                 415    
 Ser Asn Ile Glu Val Leu Arg Phe Glu Asn Ile Leu Ser Ser Ile Leu
             420                 425                 430        
 His Phe Gly Val Leu Pro Leu Ala Asn Ala Lys Leu Gln Gln Gly Phe
         435                 440                 445            
 Pro Leu Pro Asn Pro His Lys Phe Leu Phe Val Asn Ser Asp Ile Glu
     450                 455                 460                
 Val Leu Glu Gly Phe Leu Leu Ile Ser Thr Asp Leu Lys Tyr Glu Thr
 465                 470                 475                 480
 Ser Ser Lys Gln Gln Pro Ser Phe His Val Trp Glu Gly Leu Asn Leu
                 485                 490                 495    
 Ile Ser Arg Gln Trp Arg Gly Lys Ser Ala Pro
             500                 505        



      <210> 1234
      <211> 612
      <212> PRT
      <213> Homo sapiens


      <400> 1234
 Met Ala Asp Phe Ala Gly Pro Ser Ser Ala Gly Arg Lys Ala Gly Ala
   1               5                  10                  15    
 Pro Arg Cys Ser Arg Lys Ala Ala Gly Thr Lys Gln Thr Ser Thr Leu
              20                  25                  30        
 Lys Gln Glu Asp Ala Ser Lys Arg Lys Ala Glu Leu Glu Ala Ala Val
          35                  40                  45            
 Arg Lys Lys Ile Glu Phe Glu Arg Lys Ala Leu His Ile Val Glu Gln
      50                  55                  60                
 Leu Leu Glu Glu Asn Ile Thr Glu Glu Phe Leu Met Glu Cys Gly Arg
  65                  70                  75                  80
 Phe Ile Thr Pro Ala His Tyr Ser Asp Val Val Asp Glu Arg Ser Ile
                  85                  90                  95    
 Val Lys Leu Cys Gly Tyr Pro Leu Cys Gln Lys Lys Leu Gly Ile Val
             100                 105                 110        
 Pro Lys Gln Lys Tyr Lys Ile Ser Thr Lys Thr Asn Lys Val Tyr Asp
         115                 120                 125            
 Ile Thr Glu Arg Lys Ser Phe Cys Ser Asn Phe Cys Tyr Gln Ala Ser
     130                 135                 140                
 Lys Phe Phe Glu Ala Gln Ile Pro Lys Thr Pro Val Trp Val Arg Glu
 145                 150                 155                 160
 Glu Glu Arg His Pro Asp Phe Gln Leu Leu Lys Glu Glu Gln Ser Gly
                 165                 170                 175    
 His Ser Gly Glu Glu Val Gln Leu Cys Ser Lys Ala Ile Lys Thr Ser
             180                 185                 190        
 Asp Ile Asp Asn Pro Ser His Phe Glu Lys Gln Tyr Glu Ser Ser Ser
         195                 200                 205            
 Ser Ser Thr His Ser Asp Ser Ser Ser Asp Asn Glu Gln Asp Phe Val
     210                 215                 220                
 Ser Ser Ile Leu Pro Gly Asn Arg Pro Asn Ser Thr Asn Ile Arg Pro
 225                 230                 235                 240
 Gln Leu His Gln Lys Ser Ile Met Lys Lys Lys Ala Gly His Lys Ala
                 245                 250                 255    
 Asn Ser Lys His Lys Asp Lys Glu Gln Thr Val Val Asp Val Thr Glu
             260                 265                 270        
 Gln Leu Gly Asp Cys Lys Leu Asp Ser Gln Glu Lys Asp Ala Thr Cys
         275                 280                 285            
 Glu Leu Pro Leu Gln Lys Val Asn Thr Gln Ser Ser Ser Asn Ser Thr
     290                 295                 300                
 Leu Pro Glu Arg Leu Lys Ala Ser Glu Asn Ser Glu Ser Glu Tyr Ser
 305                 310                 315                 320
 Arg Ser Glu Ile Thr Leu Val Gly Ile Ser Lys Lys Ser Ala Glu His
                 325                 330                 335    
 Phe Lys Arg Lys Phe Ala Lys Ser Asn Gln Val Ser Arg Ser Val Ser
             340                 345                 350        
 Ser Ser Val Gln Val Cys Pro Glu Val Gly Lys Arg Asn Leu Leu Lys
         355                 360                 365            
 Val Leu Lys Glu Thr Leu Ile Glu Trp Lys Thr Glu Glu Thr Leu Arg
     370                 375                 380                
 Phe Leu Tyr Gly Gln Asn Tyr Ala Ser Val Cys Leu Lys Pro Glu Ala
 385                 390                 395                 400
 Ser Leu Val Lys Glu Glu Leu Asp Glu Asp Asp Ile Ile Ser Asp Pro
                 405                 410                 415    
 Asp Ser His Phe Pro Ala Trp Arg Glu Ser Gln Asn Ser Leu Asp Glu
             420                 425                 430        
 Ser Leu Pro Phe Arg Gly Ser Gly Thr Ala Ile Lys Pro Leu Pro Ser
         435                 440                 445            
 Tyr Glu Asn Leu Lys Lys Glu Thr Glu Lys Leu Asn Leu Arg Ile Arg
     450                 455                 460                
 Glu Phe Tyr Arg Gly Arg Tyr Val Leu Gly Glu Glu Thr Thr Lys Ser
 465                 470                 475                 480
 Gln Asp Ser Glu Glu His Asp Ser Thr Phe Pro Leu Ile Asp Ser Ser
                 485                 490                 495    
 Ser Gln Asn Gln Ile Arg Lys Arg Ile Val Leu Glu Lys Leu Ser Lys
             500                 505                 510        
 Val Leu Pro Gly Leu Leu Val Pro Leu Gln Ile Thr Leu Gly Asp Ile
         515                 520                 525            
 Tyr Thr Gln Leu Lys Asn Leu Val Arg Thr Phe Arg Leu Thr Asn Arg
     530                 535                 540                
 Asn Ile Ile His Lys Pro Ala Glu Trp Thr Leu Ile Ala Met Val Leu
 545                 550                 555                 560
 Leu Ser Leu Leu Thr Pro Ile Leu Gly Ile Gln Lys His Ser Gln Glu
                 565                 570                 575    
 Gly Met Val Phe Thr Arg Phe Leu Asp Thr Leu Leu Glu Glu Leu His
             580                 585                 590        
 Leu Lys Asn Glu Asp Leu Glu Ser Leu Thr Ile Ile Phe Arg Thr Ser
         595                 600                 605            
 Cys Leu Pro Glu
     610        



      <210> 1235
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 1235
 Met Pro Thr Met Trp Arg Met Leu His Gln Ala Leu Lys Leu Arg Arg
   1               5                  10                  15    
 Arg Thr Val Leu Ala Gly Gln Glu Ile Ser Tyr Val Leu Pro Val Met
              20                  25                  30        
 Phe Val Val Ser Glu Glu Asp Ser Asn Arg Asp Val Phe Leu Val Ala
          35                  40                  45            
 Gly Tyr Arg His Leu Glu Phe Gly Glu Arg Ile Ala Ile Trp Gly Ser
      50                  55                  60                
 Ser Met Gln His Val Glu Arg Arg Arg Trp Pro Leu Asp Ser Ile Gln
  65                  70                  75                  80
 Lys Arg Met Gly Gln Ser Phe Thr Gly Trp Ala Glu Glu Ala Ala Pro
                  85                  90                  95    
 Gly Met Lys Thr Lys Lys Glu Tyr Ala Glu Ile Gly Val Lys Pro Arg
             100                 105                 110        
 Gln Asn Ala Cys Glu Met Cys Pro Gly Met Ile Leu Ser Thr Thr
         115                 120                 125        



      <210> 1236
      <211> 188
      <212> PRT
      <213> Homo sapiens


      <400> 1236
 Met Met His Pro Val Ala Ser Ser Asn Pro Ala Phe Cys Gly Pro Gly
   1               5                  10                  15    
 Lys Pro Ser Cys Leu Asn Glu Asp Ala Met Arg Ala Ala Asp Gln Phe
              20                  25                  30        
 Asp Ile Tyr Ser Ser Gln Gln Ser Lys Tyr Ser His Thr Val Asn His
          35                  40                  45            
 Lys Pro Met Val Cys Gln Arg Gln Asp Pro Leu Asn Glu Thr His Leu
      50                  55                  60                
 Gln Thr Thr Ser Gly Arg Ser Ile Glu Ile Lys Asp Glu Leu Lys Lys
  65                  70                  75                  80
 Lys Lys Asn Leu Asn Arg Ser Gly Lys Arg Gly Arg Pro Ser Gly Thr
                  85                  90                  95    
 Thr Lys Ser Ala Gly Tyr Arg Thr Ser Thr Gly Arg Pro Leu Gly Thr
             100                 105                 110        
 Thr Lys Ala Ala Gly Phe Lys Thr Ser Pro Gly Arg Pro Leu Gly Thr
         115                 120                 125            
 Thr Lys Ala Ala Gly Tyr Lys Val Ser Pro Gly Arg Pro Pro Gly Ser
     130                 135                 140                
 Ile Lys Ala Leu Ser Arg Leu Ala Asp Leu Gly Tyr Gly Cys Gly Thr
 145                 150                 155                 160
 Ala Ala Phe Pro Tyr Pro Met Met His Gly Arg Ala Val His Gly Val
                 165                 170                 175    
 Glu Glu Thr Ser Ser Glu Val Lys Pro Pro Asn Glu
             180                 185            



      <210> 1237
      <211> 688
      <212> PRT
      <213> Homo sapiens


      <400> 1237
 Met Cys Val Ile Asp Tyr Leu His Arg Thr Arg Ala Met Ser Asp Phe
   1               5                  10                  15    
 His Val His Pro Gln Ala Thr Val Gly Glu Glu Gly Gly Val Ala Arg
              20                  25                  30        
 Phe Gln Cys Gln Ile His Gly Leu Pro Lys Pro Leu Ile Thr Trp Glu
          35                  40                  45            
 Lys Asn Arg Val Pro Ile Asp Thr Asp Asn Glu Arg Tyr Thr Leu Leu
      50                  55                  60                
 Pro Lys Gly Val Leu Gln Ile Thr Gly Leu Arg Ala Glu Asp Gly Gly
  65                  70                  75                  80
 Ile Phe His Cys Val Ala Ser Asn Ile Ala Ser Ile Arg Ile Ser His
                  85                  90                  95    
 Gly Ala Arg Leu Thr Val Ser Gly Ser Gly Ser Gly Ala Tyr Lys Glu
             100                 105                 110        
 Pro Ala Ile Leu Val Gly Pro Glu Asn Leu Thr Leu Thr Val His Gln
         115                 120                 125            
 Thr Ala Val Leu Glu Cys Val Ala Thr Gly Asn Pro Arg Pro Ile Val
     130                 135                 140                
 Ser Trp Ser Arg Leu Asp Gly Arg Pro Ile Gly Val Glu Gly Ile Gln
 145                 150                 155                 160
 Val Leu Gly Thr Gly Asn Leu Ile Ile Ser Asp Val Thr Val Gln His
                 165                 170                 175    
 Ser Gly Val Tyr Val Cys Ala Ala Asn Arg Pro Gly Thr Arg Val Arg
             180                 185                 190        
 Arg Thr Ala Gln Gly Arg Leu Val Val Gln Ala Pro Ala Glu Phe Val
         195                 200                 205            
 Gln His Pro Gln Ser Ile Ser Arg Pro Ala Gly Thr Thr Ala Met Phe
     210                 215                 220                
 Thr Cys Gln Ala Gln Gly Glu Pro Pro Pro His Val Thr Trp Leu Lys
 225                 230                 235                 240
 Asn Gly Gln Val Leu Gly Pro Gly Gly His Val Arg Leu Lys Asn Asn
                 245                 250                 255    
 Asn Ser Thr Leu Thr Ile Ser Gly Ile Gly Pro Glu Asp Glu Ala Ile
             260                 265                 270        
 Tyr Gln Cys Val Ala Glu Asn Ser Ala Gly Ser Ser Gln Ala Ser Ala
         275                 280                 285            
 Arg Leu Thr Val Leu Trp Ala Glu Gly Leu Pro Gly Pro Pro Arg Asn
     290                 295                 300                
 Val Arg Ala Val Ser Val Ser Ser Thr Glu Val Arg Val Ser Trp Ser
 305                 310                 315                 320
 Glu Pro Leu Ala Asn Thr Lys Glu Ile Ile Gly Tyr Val Leu His Ile
                 325                 330                 335    
 Arg Lys Ala Ala Asp Pro Pro Glu Leu Glu Tyr Gln Glu Ala Val Ser
             340                 345                 350        
 Lys Ser Thr Phe Gln His Leu Val Ser Asp Leu Glu Pro Ser Thr Ala
         355                 360                 365            
 Tyr Ser Phe Tyr Ile Lys Ala Tyr Thr Pro Arg Gly Ala Ser Ser Ala
     370                 375                 380                
 Ser Val Pro Thr Leu Ala Ser Thr Leu Gly Glu Ala Pro Ala Pro Pro
 385                 390                 395                 400
 Pro Leu Ser Val Arg Val Leu Gly Ser Ser Ser Leu Gln Leu Leu Trp
                 405                 410                 415    
 Glu Pro Trp Pro Arg Leu Ala Gln His Glu Gly Gly Phe Lys Leu Phe
             420                 425                 430        
 Tyr Arg Pro Ala Ser Lys Thr Ser Phe Thr Gly Pro Ile Leu Leu Pro
         435                 440                 445            
 Gly Thr Val Ser Ser Tyr Asn Leu Ser Gln Leu Asp Pro Thr Ala Val
     450                 455                 460                
 Tyr Glu Val Lys Leu Leu Ala Tyr Asn Gln His Gly Asp Gly Asn Ala
 465                 470                 475                 480
 Thr Val Arg Phe Val Ser Leu Arg Gly Ala Ser Glu Arg Thr Ala Leu
                 485                 490                 495    
 Ser Pro Pro Cys Asp Cys Arg Lys Glu Glu Ala Ala Asn Gln Thr Ser
             500                 505                 510        
 Thr Thr Gly Ile Val Ile Gly Ile His Ile Gly Val Thr Cys Ile Ile
         515                 520                 525            
 Phe Cys Val Leu Phe Leu Leu Phe Gly Gln Arg Gly Arg Val Leu Leu
     530                 535                 540                
 Cys Lys Asp Val Glu Asn Gln Leu Ser Pro Pro Gln Gly Pro Arg Ser
 545                 550                 555                 560
 Gln Arg Asp Pro Gly Ile Leu Ala Leu Asn Gly Ala Arg Arg Gly Gln
                 565                 570                 575    
 Arg Gly Gln Leu Gly Arg Asp Glu Lys Arg Val Asp Met Lys Glu Leu
             580                 585                 590        
 Glu Gln Leu Phe Pro Pro Ala Ser Ala Ala Gly Gln Pro Asp Pro Arg
         595                 600                 605            
 Pro Thr Asp Pro Ala Ala Pro Ala Pro Cys Glu Glu Thr Gln Leu Ser
     610                 615                 620                
 Val Leu Pro Leu Gln Gly Cys Gly Leu Met Glu Gly Lys Thr Thr Glu
 625                 630                 635                 640
 Ala Lys Thr Thr Glu Ala Thr Ala Pro Cys Ala Gly Leu Ala Ala Ala
                 645                 650                 655    
 Pro Pro Pro Pro Asp Gly Gly Pro Gly Leu Leu Ser Glu Gly Gln Ala
             660                 665                 670        
 Ser Arg Pro Ala Ala Ala Arg Val Thr Gln Pro Ala His Ser Glu Gln
         675                 680                 685            





      <210> 1238
      <211> 464
      <212> PRT
      <213> Homo sapiens


      <400> 1238
 Met Glu Thr Leu Ser Phe Pro Arg Tyr Asn Val Ala Glu Ile Val Ile
   1               5                  10                  15    
 His Ile Arg Asn Lys Ile Leu Thr Gly Ala Asp Gly Lys Asn Leu Thr
              20                  25                  30        
 Lys Asn Asp Leu Tyr Pro Asn Pro Lys Pro Glu Val Leu His Met Ile
          35                  40                  45            
 Tyr Met Arg Ala Leu Gln Ile Val Tyr Gly Ile Arg Leu Glu His Phe
      50                  55                  60                
 Tyr Met Met Pro Val Asn Ser Glu Val Met Tyr Pro His Leu Met Glu
  65                  70                  75                  80
 Gly Phe Leu Pro Phe Ser Asn Leu Val Thr His Leu Asp Ser Phe Leu
                  85                  90                  95    
 Pro Ile Cys Arg Val Asn Asp Phe Glu Thr Ala Asp Ile Leu Cys Pro
             100                 105                 110        
 Lys Ala Lys Arg Thr Ser Arg Phe Leu Ser Gly Ile Ile Asn Phe Ile
         115                 120                 125            
 His Phe Arg Glu Ala Cys Arg Glu Thr Tyr Met Glu Phe Leu Trp Gln
     130                 135                 140                
 Tyr Lys Ser Ser Ala Asp Lys Met Gln Gln Leu Asn Ala Ala His Gln
 145                 150                 155                 160
 Glu Ala Leu Met Lys Leu Glu Arg Leu Asp Ser Val Pro Val Glu Glu
                 165                 170                 175    
 Gln Glu Glu Phe Lys Gln Leu Ser Asp Gly Ile Gln Glu Leu Gln Gln
             180                 185                 190        
 Ser Leu Asn Gln Asp Phe His Gln Lys Thr Ile Val Leu Gln Glu Gly
         195                 200                 205            
 Asn Ser Gln Lys Lys Ser Asn Ile Ser Glu Lys Thr Lys Arg Leu Asn
     210                 215                 220                
 Glu Leu Lys Leu Ser Val Val Ser Leu Lys Glu Ile Gln Glu Ser Leu
 225                 230                 235                 240
 Lys Thr Lys Ile Val Asp Ser Pro Glu Lys Leu Lys Asn Tyr Lys Glu
                 245                 250                 255    
 Lys Met Lys Asp Thr Val Gln Lys Leu Lys Asn Ala Arg Gln Glu Val
             260                 265                 270        
 Val Glu Lys Tyr Glu Ile Tyr Gly Asp Ser Val Asp Cys Leu Pro Ser
         275                 280                 285            
 Cys Gln Leu Glu Val Gln Leu Tyr Gln Lys Lys Ile Gln Asp Leu Ser
     290                 295                 300                
 Asp Asn Arg Glu Lys Leu Ala Ser Ile Leu Lys Glu Ser Leu Asn Leu
 305                 310                 315                 320
 Glu Asp Gln Ile Glu Ser Asp Glu Ser Glu Leu Lys Lys Leu Lys Thr
                 325                 330                 335    
 Glu Glu Asn Ser Phe Lys Arg Leu Met Ile Val Lys Lys Glu Lys Leu
             340                 345                 350        
 Ala Thr Ala Gln Phe Lys Ile Asn Lys Lys His Glu Asp Val Lys Gln
         355                 360                 365            
 Tyr Lys Arg Thr Val Ile Glu Asp Cys Asn Lys Val Gln Glu Lys Arg
     370                 375                 380                
 Gly Ala Val Tyr Glu Arg Val Thr Thr Ile Asn Gln Glu Ile Gln Lys
 385                 390                 395                 400
 Ile Lys Leu Gly Ile Gln Gln Leu Lys Asp Ala Ala Glu Arg Glu Lys
                 405                 410                 415    
 Leu Lys Ser Gln Glu Ile Phe Leu Asn Leu Lys Thr Ala Leu Glu Lys
             420                 425                 430        
 Tyr His Asp Gly Ile Glu Lys Ala Ala Glu Asp Ser Tyr Ala Lys Ile
         435                 440                 445            
 Asp Glu Lys Thr Ala Glu Leu Lys Arg Lys Met Phe Lys Met Ser Thr
     450                 455                 460                





      <210> 1239
      <211> 718
      <212> PRT
      <213> Homo sapiens


      <400> 1239
 Met Glu Leu Leu Asp Met Val Cys Met Asp Pro Leu Val Asp Asp Asn
   1               5                  10                  15    
 Asp Asp Ile Leu Asn Met Val Ile Val Ile His Ser Leu Leu Asp Ile
              20                  25                  30        
 Cys Ser Val Ile Ser Ser Met Asp His Ala Phe His Ala Asn Thr Trp
          35                  40                  45            
 Lys Phe Ile Ile Lys Gln Ser Leu Lys His Gln Ser Ile Ile Lys Ser
      50                  55                  60                
 Gln Leu Lys His Lys Asp Ile Ile Thr Ser Leu Cys Glu Asp Ile Leu
  65                  70                  75                  80
 Phe Ser Phe His Ser Cys Leu Gln Leu Ala Glu Gln Met Thr Gln Ser
                  85                  90                  95    
 Asp Ala Gln Asp Asn Ala Asp Tyr Arg Leu Phe Gln Lys Thr Leu Lys
             100                 105                 110        
 Leu Cys Arg Phe Phe Ala Asn Ser Leu Leu His Tyr Ala Lys Glu Phe
         115                 120                 125            
 Leu Pro Phe Leu Ser Asp Ser Cys Cys Thr Leu His Gln Leu Tyr Leu
     130                 135                 140                
 Gln Ile His Ser Lys Phe Pro Pro Ser Leu Tyr Ala Thr Arg Ile Ser
 145                 150                 155                 160
 Lys Ala His Gln Glu Glu Ile Ala Gly Ala Phe Leu Val Thr Leu Asp
                 165                 170                 175    
 Pro Leu Ile Ser Gln Leu Leu Thr Phe Gln Pro Phe Met Gln Val Val
             180                 185                 190        
 Leu Asp Ser Lys Leu Tyr Leu Pro Cys Glu Leu Gln Phe Pro Gln Cys
         195                 200                 205            
 Leu Leu Leu Val Val Val Met Asp Lys Leu Pro Ser Gln Pro Lys Glu
     210                 215                 220                
 Val Gln Thr Leu Trp Cys Thr Asp Ser Gln Val Ser Glu Thr Thr Thr
 225                 230                 235                 240
 Arg Ile Ser Leu Leu Lys Ala Val Phe Tyr Ser Phe Glu Gln Cys Ser
                 245                 250                 255    
 Gly Glu Leu Ser Leu Pro Val His Leu Gln Gly Leu Lys Ser Lys Gly
             260                 265                 270        
 Lys Ala Glu Val Ala Val Thr Leu Tyr Gln His Val Cys Val His Leu
         275                 280                 285            
 Cys Thr Phe Ile Thr Ser Phe His Pro Ser Leu Phe Ala Glu Leu Asp
     290                 295                 300                
 Ala Ala Leu Leu Asn Ala Val Leu Ser Ala Asn Met Ile Thr Ser Leu
 305                 310                 315                 320
 Leu Ala Met Asp Ala Trp Cys Phe Leu Ala Arg Tyr Gly Thr Ala Glu
                 325                 330                 335    
 Leu Cys Ala His His Val Thr Ile Val Ala His Leu Ile Lys Ser Cys
             340                 345                 350        
 Pro Gly Glu Cys Tyr Gln Leu Ile Asn Leu Ser Ile Leu Leu Lys Arg
         355                 360                 365            
 Leu Phe Phe Phe Met Ala Pro Pro His Gln Leu Glu Phe Ile Gln Lys
     370                 375                 380                
 Phe Ser Pro Lys Glu Ala Glu Asn Leu Pro Leu Trp Gln His Ile Ser
 385                 390                 395                 400
 Phe Gln Ala Leu Pro Pro Glu Leu Arg Glu Gln Thr Val His Glu Val
                 405                 410                 415    
 Thr Thr Val Gly Thr Ala Glu Cys Arg Lys Trp Leu Ser Arg Ser Arg
             420                 425                 430        
 Thr Leu Gly Glu Leu Glu Ser Leu Asn Thr Val Leu Ser Ala Leu Leu
         435                 440                 445            
 Ala Val Cys Asn Ser Ala Gly Glu Ala Leu Asp Thr Gly Lys Gln Thr
     450                 455                 460                
 Ala Ile Ile Glu Val Val Ser Gln Leu Trp Ala Phe Leu Asn Ile Lys
 465                 470                 475                 480
 Gln Val Ala Asp Gln Pro Tyr Val Gln Gln Thr Phe Ser Leu Leu Leu
                 485                 490                 495    
 Pro Leu Leu Gly Phe Phe Ile Gln Thr Leu Asp Pro Lys Leu Ile Leu
             500                 505                 510        
 Gln Ala Val Thr Leu Gln Thr Ser Leu Leu Lys Leu Glu Leu Pro Asp
         515                 520                 525            
 Tyr Val Arg Leu Ala Met Leu Asp Phe Val Ser Ser Leu Gly Lys Leu
     530                 535                 540                
 Phe Ile Pro Glu Ala Ile Gln Asp Arg Ile Leu Pro Asn Leu Ser Cys
 545                 550                 555                 560
 Met Phe Ala Leu Leu Leu Ala Asp Arg Ser Trp Leu Leu Glu Gln His
                 565                 570                 575    
 Thr Leu Glu Ala Phe Thr Gln Phe Ala Glu Gly Thr Asn His Glu Glu
             580                 585                 590        
 Ile Val Pro Gln Cys Leu Ser Ser Glu Glu Thr Lys Asn Lys Val Val
         595                 600                 605            
 Ser Phe Leu Glu Lys Thr Gly Phe Val Asp Glu Thr Glu Ala Ala Lys
     610                 615                 620                
 Val Glu Arg Val Lys Gln Glu Lys Gly Ile Phe Trp Glu Pro Phe Ala
 625                 630                 635                 640
 Asn Val Thr Val Glu Glu Ala Lys Arg Ser Ser Leu Gln Pro Tyr Ala
                 645                 650                 655    
 Lys Arg Ala Arg Gln Glu Phe Pro Trp Glu Glu Glu Tyr Arg Ser Ala
             660                 665                 670        
 Leu His Thr Ile Ala Gly Ala Leu Glu Ala Thr Glu Ser Leu Leu Gln
         675                 680                 685            
 Lys Gly Pro Ala Pro Ala Trp Leu Ser Met Glu Met Glu Ala Leu Gln
     690                 695                 700                
 Glu Arg Met Asp Lys Leu Lys Arg Tyr Ile His Thr Leu Gly
 705                 710                 715            



      <210> 1240
      <211> 1086
      <212> PRT
      <213> Homo sapiens


      <400> 1240
 Met Arg Val Phe Leu Leu Cys Ala Tyr Ile Leu Leu Leu Met Val Ser
   1               5                  10                  15    
 Gln Leu Arg Ala Val Ser Phe Pro Glu Asp Asp Glu Pro Leu Asn Thr
              20                  25                  30        
 Val Asp Tyr His Tyr Ser Arg Gln Tyr Pro Val Phe Arg Gly Arg Pro
          35                  40                  45            
 Ser Gly Asn Glu Ser Gln His Arg Leu Asp Phe Gln Leu Met Leu Lys
      50                  55                  60                
 Ile Arg Asp Thr Leu Tyr Ile Ala Gly Arg Asp Gln Val Tyr Thr Val
  65                  70                  75                  80
 Asn Leu Asn Glu Met Pro Lys Thr Glu Val Ile Pro Asn Lys Lys Leu
                  85                  90                  95    
 Thr Trp Arg Ser Arg Gln Gln Asp Arg Glu Asn Cys Ala Met Lys Gly
             100                 105                 110        
 Lys His Lys Asp Glu Cys His Asn Phe Ile Lys Val Phe Val Pro Arg
         115                 120                 125            
 Asn Asp Glu Met Val Phe Val Cys Gly Thr Asn Ala Phe Asn Pro Met
     130                 135                 140                
 Cys Arg Tyr Tyr Arg Leu Ser Thr Leu Glu Tyr Asp Gly Glu Glu Ile
 145                 150                 155                 160
 Ser Gly Leu Ala Arg Cys Pro Phe Asp Ala Arg Gln Thr Asn Val Ala
                 165                 170                 175    
 Leu Phe Ala Asp Gly Lys Leu Tyr Ser Ala Thr Val Ala Asp Phe Leu
             180                 185                 190        
 Ala Ser Asp Ala Val Ile Tyr Arg Ser Met Gly Asp Gly Ser Ala Leu
         195                 200                 205            
 Arg Thr Ile Lys Tyr Asp Ser Lys Trp Ile Lys Glu Pro His Phe Leu
     210                 215                 220                
 His Ala Ile Glu Tyr Gly Asn Tyr Val Tyr Phe Phe Phe Arg Glu Ile
 225                 230                 235                 240
 Ala Val Glu His Asn Asn Leu Gly Lys Ala Val Tyr Ser Arg Val Ala
                 245                 250                 255    
 Arg Ile Cys Lys Asn Asp Met Gly Gly Ser Gln Arg Val Leu Glu Lys
             260                 265                 270        
 His Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys Ser Val Pro Gly
         275                 280                 285            
 Asp Pro Phe Phe Tyr Phe Asp Val Leu Gln Ser Ile Thr Asp Ile Ile
     290                 295                 300                
 Gln Ile Asn Gly Ile Pro Thr Val Val Gly Val Phe Thr Thr Gln Leu
 305                 310                 315                 320
 Asn Ser Ile Pro Gly Ser Ala Val Cys Ala Phe Ser Met Asp Asp Ile
                 325                 330                 335    
 Glu Lys Val Phe Lys Gly Arg Phe Lys Glu Gln Lys Thr Pro Asp Ser
             340                 345                 350        
 Val Trp Thr Ala Val Pro Glu Asp Lys Val Pro Lys Pro Arg Pro Gly
         355                 360                 365            
 Cys Cys Ala Lys His Gly Leu Ala Glu Ala Tyr Lys Thr Ser Ile Asp
     370                 375                 380                
 Phe Pro Asp Glu Thr Leu Ser Phe Ile Lys Ser His Pro Leu Met Asp
 385                 390                 395                 400
 Ser Ala Val Pro Pro Ile Ala Asp Glu Pro Trp Phe Thr Lys Thr Arg
                 405                 410                 415    
 Val Arg Tyr Arg Leu Thr Ala Ile Ser Val Asp His Ser Ala Gly Pro
             420                 425                 430        
 Tyr Gln Asn Tyr Thr Val Ile Phe Val Gly Ser Glu Ala Gly Met Val
         435                 440                 445            
 Leu Lys Val Leu Ala Lys Thr Ser Pro Phe Ser Leu Asn Asp Ser Val
     450                 455                 460                
 Leu Leu Glu Glu Ile Glu Ala Tyr Asn His Ala Lys Cys Ser Ala Glu
 465                 470                 475                 480
 Asn Glu Glu Asp Lys Lys Val Ile Ser Leu Gln Leu Asp Lys Asp His
                 485                 490                 495    
 His Ala Leu Tyr Val Ala Phe Ser Ser Cys Ile Ile Arg Ile Pro Leu
             500                 505                 510        
 Ser Arg Cys Glu Arg Tyr Gly Ser Cys Lys Lys Ser Cys Ile Ala Ser
         515                 520                 525            
 Arg Asp Pro Tyr Cys Gly Trp Leu Ser Gln Gly Ser Cys Gly Arg Val
     530                 535                 540                
 Thr Pro Gly Met Leu Leu Leu Thr Glu Asp Phe Phe Ala Phe His Asn
 545                 550                 555                 560
 His Ser Ala Glu Gly Tyr Glu Gln Asp Thr Glu Phe Gly Asn Thr Ala
                 565                 570                 575    
 His Leu Gly Asp Cys His Glu Ile Leu Pro Thr Ser Thr Thr Pro Asp
             580                 585                 590        
 Tyr Lys Ile Phe Gly Gly Pro Thr Ser Asp Met Glu Val Ser Ser Ser
         595                 600                 605            
 Ser Val Thr Thr Met Ala Ser Ile Pro Glu Ile Thr Pro Lys Val Ile
     610                 615                 620                
 Asp Thr Trp Arg Pro Lys Leu Thr Ser Ser Arg Lys Phe Val Val Gln
 625                 630                 635                 640
 Asp Asp Pro Asn Thr Ser Asp Phe Thr Asp Pro Leu Ser Gly Ile Pro
                 645                 650                 655    
 Lys Gly Val Arg Trp Glu Val Gln Ser Gly Glu Ser Asn Gln Met Val
             660                 665                 670        
 His Met Asn Val Leu Ile Thr Cys Val Phe Ala Ala Phe Val Leu Gly
         675                 680                 685            
 Ala Phe Ile Ala Gly Val Ala Val Tyr Cys Tyr Arg Asp Met Phe Val
     690                 695                 700                
 Arg Lys Asn Arg Lys Ile His Lys Asp Ala Glu Ser Ala Gln Ser Cys
 705                 710                 715                 720
 Thr Asp Ser Ser Gly Ser Phe Ala Lys Leu Asn Gly Leu Phe Asp Ser
                 725                 730                 735    
 Pro Val Lys Glu Tyr Gln Gln Asn Ile Asp Ser Pro Lys Leu Tyr Ser
             740                 745                 750        
 Asn Leu Leu Thr Ser Arg Lys Glu Leu Pro Pro Asn Gly Asp Thr Lys
         755                 760                 765            
 Ser Met Val Met Asp His Arg Gly Gln Pro Pro Glu Leu Ala Ala Leu
     770                 775                 780                
 Pro Thr Pro Glu Ser Thr Pro Val Leu His Gln Lys Thr Leu Gln Ala
 785                 790                 795                 800
 Met Lys Ser His Ser Glu Lys Ala His Gly His Gly Ala Ser Arg Lys
                 805                 810                 815    
 Glu Thr Pro Gln Phe Phe Pro Ser Ser Pro Pro Pro His Ser Pro Leu
             820                 825                 830        
 Ser His Gly His Ile Pro Ser Ala Ile Val Leu Pro Asn Ala Thr His
         835                 840                 845            
 Asp Tyr Asn Thr Ser Phe Ser Asn Ser Asn Ala His Lys Ala Glu Lys
     850                 855                 860                
 Lys Leu Gln Asn Ile Asp His Pro Leu Thr Lys Ser Ser Ser Lys Arg
 865                 870                 875                 880
 Asp His Arg Arg Ser Val Asp Ser Arg Asn Thr Leu Asn Asp Leu Leu
                 885                 890                 895    
 Lys His Leu Asn Asp Pro Asn Ser Asn Pro Lys Ala Ile Met Gly Asp
             900                 905                 910        
 Ile Gln Met Ala His Gln Asn Leu Met Leu Asp Pro Met Gly Ser Met
         915                 920                 925            
 Ser Glu Val Pro Pro Lys Val Pro Asn Arg Glu Ala Ser Leu Tyr Ser
     930                 935                 940                
 Pro Pro Ser Thr Leu Pro Arg Asn Ser Pro Thr Lys Arg Val Asp Val
 945                 950                 955                 960
 Pro Thr Thr Pro Gly Val Pro Met Thr Ser Leu Glu Arg Gln Arg Gly
                 965                 970                 975    
 Tyr His Lys Asn Ser Ser Gln Arg His Ser Ile Ser Ala Met Pro Lys
             980                 985                 990        
 Asn Leu Asn Ser Pro Asn Gly Val Leu Leu Ser Arg Gln Pro Ser Met
         995                1000                1005            
 Asn Arg Gly Gly Tyr Met Pro Thr Pro Thr Gly Ala Lys Val Asp Tyr
    1010                1015                1020                
 Ile Gln Gly Thr Pro Val Ser Val His Leu Gln Pro Ser Leu Ser Arg
1025                1030                1035                1040
 Gln Ser Ser Tyr Thr Ser Asn Gly Thr Leu Pro Arg Thr Gly Leu Lys
                1045                1050                1055    
 Arg Thr Pro Ser Leu Lys Pro Asp Val Pro Pro Lys Pro Ser Phe Val
            1060                1065                1070        
 Pro Gln Thr Pro Ser Val Arg Pro Leu Asn Lys Tyr Thr Tyr
        1075                1080                1085    



      <210> 1241
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 1241
 Met Gln Cys Cys Leu Leu Leu Arg Trp Leu Ala Ser Ala Leu Leu Arg
   1               5                  10                  15    
 Leu Leu Gly Val Ala Thr Glu Lys Arg Glu Arg Val Lys Arg Ala Glu
              20                  25                  30        
 Thr Gly Cys Cys His His Thr Thr Glu Gly Gly Pro Gly Ala Gln Pro
          35                  40                  45            
 Ala Glu Gly Leu Arg Asp Arg Trp Glu Gln Glu Pro Thr Thr Arg Pro
      50                  55                  60                
 Met Glu Glu Glu Val Gly Arg Ser Gln Lys Gly Glu Glu Lys Glu Arg
  65                  70                  75                  80
 Cys Leu Phe Val His Leu Val Phe Ala Phe Lys Glu Arg Arg Arg Val
                  85                  90                  95    
 Lys
    



      <210> 1242
      <211> 58
      <212> PRT
      <213> Homo sapiens


      <400> 1242
 Met Ala His Cys Phe Leu Ser His Lys Ser Gln Thr Ile Leu Ile Ser
   1               5                  10                  15    
 Lys Pro Ala Leu Thr Gln Ser His Phe Thr Ser Pro Ala Gly Leu Phe
              20                  25                  30        
 Leu Thr Val Glu Lys Ser His Leu Leu Thr Arg Leu Phe Phe His Trp
          35                  40                  45            
 Leu Ser Leu Val Leu Cys Ser Leu Thr Glu
      50                  55            



      <210> 1243
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 1243
 Met Ala Glu Leu Val Pro Phe Ala Val Pro Ile Glu Ser Asp Lys Thr
   1               5                  10                  15    
 Leu Leu Val Trp Glu Leu Ser Ser Gly Pro Thr Ala Glu Ala Leu His
              20                  25                  30        
 His Ser Leu Phe Thr Ala Phe Ser Gln Phe Gly Leu Leu Tyr Ser Val
          35                  40                  45            
 Arg Val Phe Pro Asn Ala Ala Val Ala His Pro Gly Phe Tyr Ala Val
      50                  55                  60                
 Ile Lys Phe Tyr Ser Ala Arg Ala Ala His Arg Ala Gln Lys Ala Cys
  65                  70                  75                  80
 Asp Arg Lys Gln Leu Phe Gln Lys Ser Pro Val Lys Val Arg Leu Gly
                  85                  90                  95    
 Thr Arg His Lys Ala Val Gln His Gln Ala Leu Ala Leu Asn Ser Ser
             100                 105                 110        
 Lys Cys Gln Glu Leu Ala Asn Tyr Tyr Phe Gly Phe Asn Gly Cys Ser
         115                 120                 125            
 Lys Arg Ile Ile Lys Leu Gln Glu Leu Ser Asp Leu Glu Glu Arg Glu
     130                 135                 140                
 Asn Glu Asp Ser Met Val Pro Leu Pro Lys Gln Ser Leu Lys Phe Phe
 145                 150                 155                 160
 Cys Ala Leu Glu Val Val Leu Pro Ser Cys Asp Cys Arg Ser Pro Gly
                 165                 170                 175    
 Ile Gly Leu Val Glu Glu Pro Met Asp Lys Val Glu Glu Gly Pro Leu
             180                 185                 190        
 Ser Phe Leu Met Lys Arg Lys Thr Ala Gln Lys Leu Ala Ile Gln Lys
         195                 200                 205            
 Ala Leu Ser Asp Ala Phe Gln Lys Leu Leu Ile Val Val Leu Gly Lys
     210                 215                 220                
 Thr Val Leu Ile Ile Leu Glu Val Leu Gln Phe Gln
 225                 230                 235    



      <210> 1244
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 1244
 Met Trp Gly Tyr Leu Ser Leu Met Pro Val Phe Leu Ala Val Trp Ala
   1               5                  10                  15    
 Ile Ser Gly Val Trp Ile Val Phe Ala Ile Ala Val Thr Asn Arg Thr
              20                  25                  30        
 Val Asp Leu Ser Lys Gly Phe Pro Tyr Ile Ser Ile Cys Gly Ser Phe
          35                  40                  45            
 Pro Pro Gln Ser Cys Ile Phe Ser Gln Val Leu Asn Met Gly Ala Ala
      50                  55                  60                
 Leu Ala Ala Trp Ile Cys Ile Val Arg Tyr His Gln Leu Arg Asp Trp
  65                  70                  75                  80
 Gly Val Arg Arg Trp Pro Asn Gln Leu Ile Leu Trp Thr Gly Leu Leu
                  85                  90                  95    
 Cys Ala Leu Gly Thr Ser Arg Gly Arg Gln Phe Pro Gly Lys Glu Pro
             100                 105                 110        
 Ala Ala Tyr Ala Leu Gly Arg Gly Leu Pro Cys Leu His Leu Gly
         115                 120                 125        



      <210> 1245
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 1245
 Met Trp Gly Tyr Leu Ser Leu Met Pro Val Phe Leu Ala Val Trp Ala
   1               5                  10                  15    
 Ile Ser Gly Val Trp Ile Val Phe Ala Ile Ala Val Thr Asn Arg Thr
              20                  25                  30        
 Val Asp Leu Ser Lys Gly Phe Pro Tyr Ile Ser Ile Cys Gly Ser Phe
          35                  40                  45            
 Pro Pro Gln Ser Cys Ile Phe Ser Gln Val Leu Asn Met Gly Ala Ala
      50                  55                  60                
 Leu Ala Ala Trp Ile Cys Ile Val Arg Tyr His Gln Leu Arg Asp Trp
  65                  70                  75                  80
 Gly Val Arg Arg Trp Pro Asn Gln Leu Ile Leu Trp Thr Gly Leu Leu
                  85                  90                  95    
 Cys Ala Leu Gly Thr Ser Val Val Gly Asn Phe Gln Glu Lys Asn Gln
             100                 105                 110        
 Arg Pro Thr His Leu Ala Gly Ala Phe Leu Ala Phe Ile Leu Gly Asn
         115                 120                 125            
 Val Tyr Phe Trp Leu Gln Leu Leu Leu Trp Arg Leu Lys Arg Leu Pro
     130                 135                 140                
 Gln Pro Gly Ala Ala Trp Ile Gly Pro Leu Arg Leu Gly Leu Cys Ser
 145                 150                 155                 160
 Val Cys Thr Ile Leu Ile Val Ala Val Ile Val Leu His Ala Cys Ser
                 165                 170                 175    
 Leu Arg Ser Val Ser Ala Ala Cys Glu Trp Val Val Ala Met Leu Leu
             180                 185                 190        
 Phe Ala Leu Phe Gly Leu Leu Ala Val Asp Phe Ser Ala Leu Glu Ser
         195                 200                 205            
 Cys Thr Leu Cys Val Gln Pro Trp Pro Ser Leu Ser Pro Pro Pro Ala
     210                 215                 220                
 Ser Pro Ile Ser Leu Pro Val Gln Leu
 225                 230            



      <210> 1246
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 1246
 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His
   1               5                  10                  15    
 Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser
              20                  25                  30        
 Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln
          35                  40                  45            
 Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp
      50                  55                  60                
 Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp
  65                  70                  75                  80
 Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile
                  85                  90                  95    
 Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly
             100                 105                 110        
 Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys
         115                 120                 125            
 Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn
     130                 135                 140                
 Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu
 145                 150                 155                 160
 Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly
                 165                 170                 175    
 Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser
             180                 185                 190        
 Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val
         195                 200                 205            
 Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys
     210                 215                 220                
 Tyr Ser Glu Glu Gly Gly
 225                 230



      <210> 1247
      <211> 1140
      <212> PRT
      <213> Homo sapiens


      <400> 1247
 Met Val Ile Ser Leu Asn Ser Cys Leu Ser Phe Ile Cys Leu Leu Leu
   1               5                  10                  15    
 Cys His Trp Ile Gly Thr Ala Ser Pro Leu Asn Leu Glu Asp Pro Asn
              20                  25                  30        
 Val Cys Ser His Trp Glu Ser Tyr Ser Val Thr Val Gln Glu Ser Tyr
          35                  40                  45            
 Pro His Pro Phe Asp Gln Ile Tyr Tyr Thr Ser Cys Thr Asp Ile Leu
      50                  55                  60                
 Asn Trp Phe Lys Cys Thr Arg His Arg Val Ser Tyr Arg Thr Ala Tyr
  65                  70                  75                  80
 Arg His Gly Glu Lys Thr Met Tyr Arg Arg Lys Ser Gln Cys Cys Pro
                  85                  90                  95    
 Gly Phe Tyr Glu Ser Gly Glu Met Cys Val Pro His Cys Ala Asp Lys
             100                 105                 110        
 Cys Val His Gly Arg Cys Ile Ala Pro Asn Thr Cys Gln Cys Glu Pro
         115                 120                 125            
 Gly Trp Gly Gly Thr Asn Cys Ser Ser Ala Cys Asp Gly Asp His Trp
     130                 135                 140                
 Gly Pro His Cys Thr Ser Arg Cys Gln Cys Lys Asn Gly Ala Leu Cys
 145                 150                 155                 160
 Asn Pro Ile Thr Gly Ala Cys His Cys Ala Ala Gly Phe Arg Gly Trp
                 165                 170                 175    
 Arg Cys Glu Asp Arg Cys Glu Gln Gly Thr Tyr Gly Asn Asp Cys His
             180                 185                 190        
 Gln Arg Cys Gln Cys Gln Asn Gly Ala Thr Cys Asp His Val Thr Gly
         195                 200                 205            
 Glu Cys Arg Cys Pro Pro Gly Tyr Thr Gly Ala Phe Cys Glu Asp Leu
     210                 215                 220                
 Cys Pro Pro Gly Lys His Gly Pro Gln Cys Glu Gln Arg Cys Pro Cys
 225                 230                 235                 240
 Gln Asn Gly Gly Val Cys His His Val Thr Gly Glu Cys Ser Cys Pro
                 245                 250                 255    
 Ser Gly Trp Met Gly Thr Val Cys Gly Gln Pro Cys Pro Glu Gly Arg
             260                 265                 270        
 Phe Gly Lys Asn Cys Ser Gln Glu Cys Gln Cys His Asn Gly Gly Thr
         275                 280                 285            
 Cys Asp Ala Ala Thr Gly Gln Cys His Cys Ser Pro Gly Tyr Thr Gly
     290                 295                 300                
 Glu Arg Cys Gln Asp Glu Cys Pro Val Gly Thr Tyr Gly Val Leu Cys
 305                 310                 315                 320
 Ala Glu Thr Cys Gln Cys Val Asn Gly Gly Lys Cys Tyr His Val Ser
                 325                 330                 335    
 Gly Ala Cys Leu Cys Glu Ala Gly Phe Ala Gly Glu Arg Cys Glu Ala
             340                 345                 350        
 Arg Leu Cys Pro Glu Gly Leu Tyr Gly Ile Lys Cys Asp Lys Arg Cys
         355                 360                 365            
 Pro Cys His Leu Glu Asn Thr His Ser Cys His Pro Met Ser Gly Glu
     370                 375                 380                
 Cys Ala Cys Lys Pro Gly Trp Ser Gly Leu Tyr Cys Asn Glu Thr Cys
 385                 390                 395                 400
 Ser Pro Gly Phe Tyr Gly Glu Ala Cys Gln Gln Ile Cys Ser Cys Gln
                 405                 410                 415    
 Asn Gly Ala Asp Cys Asp Ser Val Thr Gly Lys Cys Thr Cys Ala Pro
             420                 425                 430        
 Gly Phe Lys Gly Ile Asp Cys Ser Thr Pro Cys Pro Leu Gly Thr Tyr
         435                 440                 445            
 Gly Ile Asn Cys Ser Ser Arg Cys Gly Cys Lys Asn Asp Ala Val Cys
     450                 455                 460                
 Ser Pro Val Asp Gly Ser Cys Thr Cys Lys Ala Gly Trp His Gly Val
 465                 470                 475                 480
 Asp Cys Ser Ile Arg Cys Pro Ser Gly Thr Trp Gly Phe Gly Cys Asn
                 485                 490                 495    
 Leu Thr Cys Gln Cys Leu Asn Gly Gly Ala Cys Asn Thr Leu Asp Gly
             500                 505                 510        
 Thr Cys Thr Cys Ala Pro Gly Trp Arg Gly Glu Lys Cys Glu Leu Pro
         515                 520                 525            
 Cys Gln Asp Gly Thr Tyr Gly Leu Asn Cys Ala Glu Arg Cys Asp Cys
     530                 535                 540                
 Ser His Ala Asp Gly Cys His Pro Thr Thr Gly His Cys Arg Cys Leu
 545                 550                 555                 560
 Pro Gly Trp Ser Gly Val His Cys Asp Ser Val Cys Ala Glu Gly Arg
                 565                 570                 575    
 Trp Gly Pro Asn Cys Ser Leu Pro Cys Tyr Cys Lys Asn Gly Ala Ser
             580                 585                 590        
 Cys Ser Pro Asp Asp Gly Ile Cys Glu Cys Ala Pro Gly Phe Arg Gly
         595                 600                 605            
 Thr Thr Cys Gln Arg Ile Cys Ser Pro Gly Phe Tyr Gly His Arg Cys
     610                 615                 620                
 Ser Gln Thr Cys Pro Gln Cys Val His Ser Ser Gly Pro Cys His His
 625                 630                 635                 640
 Ile Thr Gly Leu Cys Asp Cys Leu Pro Gly Phe Thr Gly Ala Leu Cys
                 645                 650                 655    
 Asn Glu Val Cys Pro Ser Gly Arg Phe Gly Lys Asn Cys Ala Gly Ile
             660                 665                 670        
 Cys Thr Cys Thr Asn Asn Gly Thr Cys Asn Pro Ile Asp Arg Ser Cys
         675                 680                 685            
 Gln Cys Tyr Pro Gly Trp Ile Gly Ser Asp Cys Ser Gln Pro Cys Pro
     690                 695                 700                
 Pro Ala His Trp Gly Pro Asn Cys Ile His Thr Cys Asn Cys His Asn
 705                 710                 715                 720
 Gly Ala Phe Cys Ser Ala Tyr Asp Gly Glu Cys Lys Cys Thr Pro Gly
                 725                 730                 735    
 Trp Thr Gly Leu Tyr Cys Thr Gln Arg Cys Pro Leu Gly Phe Tyr Gly
             740                 745                 750        
 Lys Asp Cys Ala Leu Ile Cys Gln Cys Gln Asn Gly Ala Asp Cys Asp
         755                 760                 765            
 His Ile Ser Gly Gln Cys Thr Cys Arg Thr Gly Phe Met Gly Arg His
     770                 775                 780                
 Cys Glu Gln Lys Cys Pro Ser Gly Thr Tyr Gly Tyr Gly Cys Arg Gln
 785                 790                 795                 800
 Ile Cys Asp Cys Leu Asn Asn Ser Thr Cys Asp His Ile Thr Gly Thr
                 805                 810                 815    
 Cys Tyr Cys Ser Pro Gly Trp Lys Gly Ala Arg Cys Asp Gln Ala Gly
             820                 825                 830        
 Val Ile Ile Val Gly Asn Leu Asn Ser Leu Ser Arg Thr Ser Thr Ala
         835                 840                 845            
 Leu Pro Ala Asp Ser Tyr Gln Ile Gly Ala Ile Ala Gly Ile Ile Ile
     850                 855                 860                
 Leu Val Leu Val Val Leu Phe Leu Leu Ala Leu Phe Ile Ile Tyr Arg
 865                 870                 875                 880
 His Lys Gln Lys Gly Lys Glu Ser Ser Met Pro Ala Val Thr Tyr Thr
                 885                 890                 895    
 Pro Ala Met Arg Val Val Asn Ala Asp Tyr Thr Ile Ser Gly Thr Leu
             900                 905                 910        
 Pro His Ser Asn Gly Gly Asn Ala Asn Ser His Tyr Phe Thr Asn Pro
         915                 920                 925            
 Ser Tyr His Thr Leu Thr Gln Cys Ala Thr Ser Pro His Val Asn Asn
     930                 935                 940                
 Arg Asp Arg Met Thr Val Thr Lys Ser Lys Asn Asn Gln Leu Phe Val
 945                 950                 955                 960
 Asn Leu Lys Asn Val Asn Pro Gly Lys Arg Gly Pro Val Gly Asp Cys
                 965                 970                 975    
 Thr Gly Thr Leu Pro Ala Asp Trp Lys His Gly Gly Tyr Leu Asn Glu
             980                 985                 990        
 Leu Gly Ala Phe Gly Leu Asp Arg Ser Tyr Met Gly Lys Ser Leu Lys
         995                1000                1005            
 Asp Leu Gly Lys Asn Ser Glu Tyr Asn Ser Ser Asn Cys Ser Leu Ser
    1010                1015                1020                
 Ser Ser Glu Asn Pro Tyr Ala Thr Ile Lys Asp Pro Pro Val Leu Ile
1025                1030                1035                1040
 Pro Lys Ser Ser Glu Cys Gly Tyr Val Glu Met Lys Ser Pro Ala Arg
                1045                1050                1055    
 Arg Asp Ser Pro Tyr Ala Glu Ile Asn Asn Ser Thr Ser Ala Asn Arg
            1060                1065                1070        
 Asn Val Tyr Glu Val Glu Pro Thr Val Ser Val Val Gln Gly Val Phe
        1075                1080                1085            
 Ser Asn Asn Gly Arg Leu Ser Gln Asp Pro Tyr Asp Leu Pro Lys Asn
    1090                1095                1100                
 Ser His Ile Pro Cys His Tyr Asp Leu Leu Pro Val Arg Asp Ser Ser
1105                1110                1115                1120
 Ser Ser Pro Lys Gln Glu Asp Ser Gly Gly Ser Ser Ser Asn Ser Ser
                1125                1130                1135    
 Ser Ser Ser Glu
            1140



      <210> 1248
      <211> 842
      <212> PRT
      <213> Homo sapiens


      <400> 1248
 Met Gly Tyr Leu Arg Ile Phe Ser Pro His Pro Ala Lys Thr Gly Asp
   1               5                  10                  15    
 Gly Ala Gln Ala Glu Asp Leu Leu Leu Glu Val Asp Leu Arg Asp Pro
              20                  25                  30        
 Val Leu Gln Val Glu Val Gly Lys Phe Val Ser Gly Thr Glu Met Leu
          35                  40                  45            
 His Leu Ala Val Leu His Ser Arg Lys Leu Cys Val Tyr Ser Val Ser
      50                  55                  60                
 Gly Thr Leu Gly Asn Val Glu His Gly Asn Gln Cys Gln Met Lys Leu
  65                  70                  75                  80
 Met Tyr Glu His Asn Leu Gln Arg Thr Ala Cys Asn Met Thr Tyr Gly
                  85                  90                  95    
 Ser Phe Gly Gly Val Lys Gly Arg Asp Leu Ile Cys Ile Gln Ser Met
             100                 105                 110        
 Asp Gly Met Leu Met Val Phe Glu Gln Glu Ser Tyr Ala Phe Gly Arg
         115                 120                 125            
 Phe Leu Pro Gly Phe Leu Leu Pro Gly Pro Leu Ala Tyr Ser Ser Arg
     130                 135                 140                
 Thr Asp Ser Phe Leu Thr Val Ser Ser Cys Gln Gln Val Glu Ser Tyr
 145                 150                 155                 160
 Lys Tyr Gln Val Leu Ala Phe Ala Thr Asp Ala Asp Lys Arg Gln Glu
                 165                 170                 175    
 Thr Glu Gln Gln Lys Leu Gly Ser Gly Lys Arg Leu Val Val Asp Trp
             180                 185                 190        
 Thr Leu Asn Ile Gly Glu Gln Ala Leu Asp Ile Cys Ile Val Ser Phe
         195                 200                 205            
 Asn Gln Ser Ala Ser Ser Val Phe Val Leu Gly Glu Arg Asn Phe Phe
     210                 215                 220                
 Cys Leu Lys Asp Asn Gly Gln Ile Arg Phe Met Lys Lys Leu Asp Trp
 225                 230                 235                 240
 Ser Pro Ser Cys Phe Leu Pro Tyr Cys Ser Val Ser Glu Gly Thr Ile
                 245                 250                 255    
 Asn Thr Leu Ile Gly Asn His Asn Asn Met Leu His Ile Tyr Gln Asp
             260                 265                 270        
 Val Thr Leu Lys Trp Ala Thr Gln Leu Pro His Ile Pro Val Ala Val
         275                 280                 285            
 Arg Val Gly Cys Leu His Asp Leu Lys Gly Val Ile Val Thr Leu Ser
     290                 295                 300                
 Asp Asp Gly His Leu Gln Cys Ser Tyr Leu Gly Thr Asp Pro Ser Leu
 305                 310                 315                 320
 Phe Gln Ala Pro Asn Val Gln Ser Arg Glu Leu Asn Tyr Asp Glu Leu
                 325                 330                 335    
 Asp Val Glu Met Lys Glu Leu Gln Lys Ile Ile Lys Asp Val Asn Lys
             340                 345                 350        
 Ser Gln Gly Val Trp Pro Met Thr Glu Arg Glu Asp Asp Leu Asn Val
         355                 360                 365            
 Ser Val Val Val Ser Pro Asn Phe Asp Ser Val Ser Gln Ala Thr Asp
     370                 375                 380                
 Val Glu Val Gly Thr Asp Leu Val Pro Ser Val Thr Val Lys Val Thr
 385                 390                 395                 400
 Leu Gln Asn Arg Val Ile Leu Gln Lys Ala Lys Leu Ser Val Tyr Val
                 405                 410                 415    
 Gln Pro Pro Leu Glu Leu Thr Cys Asp Gln Phe Thr Phe Glu Phe Met
             420                 425                 430        
 Thr Pro Asp Leu Thr Arg Thr Val Ser Phe Ser Val Tyr Leu Lys Arg
         435                 440                 445            
 Ser Tyr Thr Pro Ser Glu Leu Glu Gly Asn Ala Val Val Ser Tyr Ser
     450                 455                 460                
 Arg Pro Thr Asp Arg Asn Pro Asp Gly Ile Pro Arg Val Ile Gln Cys
 465                 470                 475                 480
 Lys Phe Arg Leu Pro Leu Lys Leu Ile Cys Leu Pro Gly Gln Pro Ser
                 485                 490                 495    
 Lys Thr Ala Ser His Lys Ile Thr Ile Asp Thr Asn Lys Ser Pro Val
             500                 505                 510        
 Ser Leu Leu Ser Leu Phe Pro Gly Phe Ala Ser Gln Ser Asp Asp Asp
         515                 520                 525            
 Gln Val Asn Val Met Gly Phe His Phe Leu Gly Gly Ala Arg Ile Thr
     530                 535                 540                
 Val Leu Ala Ser Lys Thr Ser Gln Arg Tyr Arg Ile Gln Ser Glu Gln
 545                 550                 555                 560
 Phe Glu Asp Leu Trp Leu Ile Thr Asn Glu Leu Ile Leu Arg Leu Gln
                 565                 570                 575    
 Glu Tyr Phe Glu Lys Gln Gly Val Lys Asp Phe Ala Cys Ser Phe Ser
             580                 585                 590        
 Gly Ser Ile Pro Leu Gln Glu Tyr Phe Glu Leu Ile Asp His His Phe
         595                 600                 605            
 Glu Leu Arg Ile Asn Gly Glu Lys Leu Glu Glu Leu Leu Ser Glu Arg
     610                 615                 620                
 Ala Val Gln Phe Arg Ala Ile Gln Arg Arg Leu Leu Ala Arg Phe Lys
 625                 630                 635                 640
 Asp Lys Thr Pro Ala Pro Leu Gln His Leu Asp Thr Leu Leu Asp Gly
                 645                 650                 655    
 Thr Tyr Lys Gln Val Ile Ala Leu Ala Asp Ala Val Glu Glu Asn Gln
             660                 665                 670        
 Gly Asn Leu Phe Gln Ser Phe Thr Arg Leu Lys Ser Ala Thr His Leu
         675                 680                 685            
 Val Ile Leu Leu Ile Ala Leu Trp Gln Lys Leu Ser Ala Asp Gln Val
     690                 695                 700                
 Ala Ile Leu Glu Ala Ala Phe Leu Pro Val Gln Glu Asp Thr Gln Glu
 705                 710                 715                 720
 Leu Gly Trp Glu Glu Thr Val Asp Ala Ala Ile Ser His Leu Leu Lys
                 725                 730                 735    
 Thr Cys Leu Ser Lys Ser Ser Lys Glu Gln Ala Leu Asn Leu Asn Ser
             740                 745                 750        
 Gln Leu Asn Ile Pro Lys Asp Thr Ser Gln Leu Lys Lys His Ile Thr
         755                 760                 765            
 Leu Leu Cys Asp Arg Leu Ser Lys Gly Gly Arg Leu Cys Leu Ser Thr
     770                 775                 780                
 Asp Ala Ala Ala Pro Gln Thr Met Val Met Pro Gly Gly Cys Thr Thr
 785                 790                 795                 800
 Ile Pro Glu Ser Asp Leu Glu Glu Arg Ser Val Glu Gln Asp Ser Thr
                 805                 810                 815    
 Glu Leu Phe Thr Asn His Arg His Leu Thr Ala Glu Thr Pro Arg Pro
             820                 825                 830        
 Glu Val Ser Pro Leu Gln Gly Val Ser Glu
         835                 840        



      <210> 1249
      <211> 250
      <212> PRT
      <213> Homo sapiens


      <400> 1249
 Met Gln Val Gln Leu Gly Gln Val Glu Ile Lys Cys Pro Ile Thr Glu
   1               5                  10                  15    
 Cys Phe Glu Phe Leu Glu Glu Thr Thr Val Val Tyr Asn Leu Thr His
              20                  25                  30        
 Glu Asp Ser Ile Lys Tyr Lys Tyr Phe Leu Glu Leu Gly Arg Ile Asp
          35                  40                  45            
 Ser Ser Thr Lys Pro Cys Pro Gln Cys Lys His Phe Thr Thr Phe Lys
      50                  55                  60                
 Lys Lys Gly His Ile Pro Thr Pro Ser Arg Ser Glu Ser Lys Tyr Lys
  65                  70                  75                  80
 Ile Gln Cys Pro Thr Cys Gln Phe Val Trp Cys Phe Lys Cys His Ser
                  85                  90                  95    
 Pro Trp His Glu Gly Val Asn Cys Lys Glu Tyr Lys Lys Gly Asp Lys
             100                 105                 110        
 Leu Leu Arg His Trp Ala Ser Glu Ile Glu His Gly Gln Arg Asn Ala
         115                 120                 125            
 Gln Lys Cys Pro Lys Cys Lys Ile His Ile Gln Arg Thr Glu Gly Cys
     130                 135                 140                
 Asp His Met Thr Cys Ser Gln Cys Asn Thr Asn Phe Cys Tyr Arg Cys
 145                 150                 155                 160
 Gly Glu Arg Tyr Arg Gln Leu Arg Phe Phe Gly Asp His Thr Ser Asn
                 165                 170                 175    
 Leu Ser Ile Phe Gly Cys Lys Tyr Arg Tyr Leu Pro Glu Arg Pro His
             180                 185                 190        
 Leu Arg Arg Leu Val Arg Gly Ser Val Cys Ala Gly Lys Leu Phe Ile
         195                 200                 205            
 Ala Pro Leu Ile Met Val Leu Gly Leu Ala Leu Gly Ala Ile Ala Val
     210                 215                 220                
 Val Ile Gly Leu Phe Val Phe Pro Ile Tyr Cys Leu Cys Lys Lys Gln
 225                 230                 235                 240
 Arg Lys Arg Ser Arg Thr Gly Met His Trp
                 245                 250



      <210> 1250
      <211> 279
      <212> PRT
      <213> Homo sapiens


      <400> 1250
 Met Gly Leu Ser Pro Gly Ala Glu Gly Glu Tyr Ala Leu Arg Leu Pro
   1               5                  10                  15    
 Arg Ile Pro Pro Pro Leu Pro Lys Pro Ala Ser Arg Thr Ala Gly Thr
              20                  25                  30        
 Gly Pro Lys Asp Gln Pro Pro Ala Leu Arg Arg Ser Ala Val Pro His
          35                  40                  45            
 Ser Gly Leu Asn Ser Ile Ser Pro Leu Glu Leu Glu Glu Ser Val Gly
      50                  55                  60                
 Phe Ala Ala Leu Val Gln Leu Pro Ala Lys Gln Pro Pro Pro Gly Thr
  65                  70                  75                  80
 Leu Glu Gln Gly Arg Ser Ile Gln Gln Gly Glu Lys Ala Val Val Ser
                  85                  90                  95    
 Leu Glu Thr Thr Pro Ser Gln Lys Ala Asp Trp Ser Ser Ile Pro Lys
             100                 105                 110        
 Pro Glu Asn Glu Gly Lys Leu Ile Lys Gln Ala Ala Glu Gly Lys Pro
         115                 120                 125            
 Arg Pro Arg Pro Gly Asp Leu Ile Glu Ile Phe Arg Ile Gly Tyr Glu
     130                 135                 140                
 His Trp Ala Ile Tyr Val Glu Asp Asp Cys Val Val His Leu Ala Pro
 145                 150                 155                 160
 Pro Ser Glu Glu Phe Glu Val Gly Ser Ile Thr Ser Ile Phe Ser Asn
                 165                 170                 175    
 Arg Ala Val Val Lys Tyr Ser Arg Leu Glu Asp Val Leu His Gly Cys
             180                 185                 190        
 Ser Trp Lys Val Asn Asn Lys Leu Asp Gly Thr Tyr Leu Pro Leu Pro
         195                 200                 205            
 Val Asp Lys Ile Ile Gln Arg Thr Lys Lys Met Val Asn Lys Ile Val
     210                 215                 220                
 Gln Tyr Ser Leu Ile Glu Gly Asn Cys Glu His Phe Val Asn Gly Leu
 225                 230                 235                 240
 Arg Tyr Gly Val Pro Arg Ser Gln Gln Val Glu His Ala Leu Met Glu
                 245                 250                 255    
 Gly Ala Lys Ala Ala Gly Ala Val Ile Ser Ala Val Val Asp Ser Ile
             260                 265                 270        
 Lys Pro Lys Pro Ile Thr Ala
         275                



      <210> 1251
      <211> 393
      <212> PRT
      <213> Homo sapiens


      <400> 1251
 Met Ser Val Thr Lys Ser Thr Glu Gly Pro Gln Gly Ala Val Ala Ile
   1               5                  10                  15    
 Lys Leu Asp Leu Met Ser Pro Pro Glu Ser Ala Lys Lys Leu Glu Asn
              20                  25                  30        
 Lys Asp Ser Thr Phe Leu Asp Glu Ser Pro Ser Glu Ser Ala Gly Leu
          35                  40                  45            
 Lys Lys Thr Lys Gly Ile Thr Val Phe Gln Ala Leu Ile His Leu Val
      50                  55                  60                
 Lys Gly Asn Met Gly Thr Gly Ile Leu Gly Leu Pro Leu Ala Val Lys
  65                  70                  75                  80
 Asn Ala Gly Ile Leu Met Gly Pro Leu Ser Leu Leu Val Met Gly Phe
                  85                  90                  95    
 Ile Ala Cys His Cys Met His Ile Leu Val Lys Cys Ala Gln Arg Phe
             100                 105                 110        
 Cys Lys Arg Leu Asn Lys Pro Phe Met Asp Tyr Gly Asp Thr Val Met
         115                 120                 125            
 His Gly Leu Glu Ala Asn Pro Asn Ala Trp Leu Gln Asn His Ala His
     130                 135                 140                
 Trp Gly Arg His Ile Val Ser Phe Phe Leu Ile Ile Thr Gln Leu Gly
 145                 150                 155                 160
 Phe Cys Cys Val Tyr Ile Val Phe Leu Ala Asp Asn Leu Lys Gln Val
                 165                 170                 175    
 Val Glu Ala Val Asn Ser Thr Thr Asn Asn Cys Tyr Ser Asn Glu Thr
             180                 185                 190        
 Val Ile Leu Thr Pro Thr Met Asp Ser Arg Leu Tyr Met Leu Ser Phe
         195                 200                 205            
 Leu Pro Phe Leu Val Leu Leu Val Leu Ile Arg Asn Leu Arg Ile Leu
     210                 215                 220                
 Thr Ile Phe Ser Met Leu Ala Asn Ile Ser Met Leu Val Ser Leu Val
 225                 230                 235                 240
 Ile Ile Ile Gln Tyr Ile Thr Gln Glu Ile Pro Asp Pro Ser Arg Leu
                 245                 250                 255    
 Pro Leu Val Ala Ser Trp Lys Thr Tyr Pro Leu Phe Phe Gly Thr Ala
             260                 265                 270        
 Ile Phe Ser Phe Glu Ser Ile Gly Val Val Leu Pro Leu Glu Asn Lys
         275                 280                 285            
 Met Lys Asn Ala Arg His Phe Pro Ala Ile Leu Ser Leu Gly Met Ser
     290                 295                 300                
 Ile Val Thr Ser Leu Tyr Ile Gly Met Ala Ala Leu Gly Tyr Leu Arg
 305                 310                 315                 320
 Phe Gly Asp Asp Ile Lys Ala Ser Ile Ser Leu Asn Leu Pro Asn Cys
                 325                 330                 335    
 Trp Leu Tyr Gln Ser Val Lys Leu Leu Tyr Ile Ala Gly Ile Leu Cys
             340                 345                 350        
 Thr Tyr Ala Leu Gln Phe Tyr Val Pro Ala Glu Ile Ile Ile Pro Phe
         355                 360                 365            
 Ala Ile Ser Arg Val Ser Thr Arg Trp Ala Leu Pro Leu Asp Leu Ser
     370                 375                 380                
 Ile Arg Leu Val Met Val Cys Leu Thr
 385                 390            



      <210> 1252
      <211> 434
      <212> PRT
      <213> Homo sapiens


      <400> 1252
 Met Ser Thr Gln Arg Leu Arg Asn Glu Asp Tyr His Asp Tyr Ser Ser
   1               5                  10                  15    
 Thr Asp Val Ser Pro Glu Glu Ser Pro Ser Glu Gly Leu Asn Asn Leu
              20                  25                  30        
 Ser Ser Pro Gly Ser Tyr Gln Arg Phe Gly Gln Ser Asn Ser Thr Thr
          35                  40                  45            
 Trp Phe Gln Thr Leu Ile His Leu Leu Lys Gly Asn Ile Gly Thr Gly
      50                  55                  60                
 Leu Leu Gly Leu Pro Leu Ala Ala Lys Asn Ala Gly Ile Val Met Gly
  65                  70                  75                  80
 Pro Ile Ser Leu Leu Ile Ile Gly Ile Val Ala Val His Cys Met Gly
                  85                  90                  95    
 Ile Leu Val Lys Cys Ala His His Phe Cys Arg Arg Leu Asn Lys Ser
             100                 105                 110        
 Phe Val Asp Tyr Gly Asp Thr Val Met Tyr Gly Leu Glu Ser Ser Pro
         115                 120                 125            
 Cys Ser Trp Leu Arg Asn His Ala His Trp Gly Arg Arg Val Val Asp
     130                 135                 140                
 Phe Phe Leu Ile Val Thr Gln Leu Gly Phe Cys Cys Val Tyr Phe Val
 145                 150                 155                 160
 Phe Leu Ala Asp Asn Phe Lys Gln Val Ile Glu Ala Ala Asn Gly Thr
                 165                 170                 175    
 Thr Asn Asn Cys His Asn Asn Glu Thr Val Ile Leu Thr Pro Thr Met
             180                 185                 190        
 Asp Ser Arg Leu Tyr Met Leu Ser Phe Leu Pro Phe Leu Val Leu Leu
         195                 200                 205            
 Val Phe Ile Arg Asn Leu Arg Ala Leu Ser Ile Phe Ser Leu Leu Ala
     210                 215                 220                
 Asn Ile Thr Met Leu Val Ser Leu Val Met Ile Tyr Gln Phe Ile Val
 225                 230                 235                 240
 Gln Arg Ile Pro Asp Pro Ser His Leu Pro Leu Val Ala Pro Trp Lys
                 245                 250                 255    
 Thr Tyr Pro Leu Phe Phe Gly Thr Ala Ile Phe Ser Phe Glu Gly Ile
             260                 265                 270        
 Gly Met Val Leu Pro Leu Glu Asn Lys Met Lys Asp Pro Arg Lys Phe
         275                 280                 285            
 Pro Leu Ile Leu Tyr Leu Gly Met Val Ile Val Thr Ile Leu Tyr Ile
     290                 295                 300                
 Ser Leu Gly Cys Leu Gly Tyr Leu Gln Phe Gly Ala Asn Ile Gln Gly
 305                 310                 315                 320
 Ser Ile Thr Leu Asn Leu Pro Asn Cys Trp Leu Tyr Gln Ser Val Lys
                 325                 330                 335    
 Leu Leu Tyr Ser Ile Gly Ile Phe Phe Thr Tyr Ala Leu Gln Phe Tyr
             340                 345                 350        
 Val Pro Ala Glu Ile Ile Ser Leu Val Gly Ser Val Ser Ser Ser Ala
         355                 360                 365            
 Leu Ala Leu Ile Ile Pro Pro Leu Leu Glu Val Thr Thr Phe Tyr Ser
     370                 375                 380                
 Glu Gly Met Ser Pro Leu Thr Ile Phe Lys Asp Ala Leu Ile Ser Ile
 385                 390                 395                 400
 Leu Gly Phe Val Gly Phe Val Val Gly Thr Tyr Glu Ala Leu Tyr Glu
                 405                 410                 415    
 Leu Ile Arg Pro Ser Asn Ala Pro Ile Phe Ile Asn Ser Thr Cys Ala
             420                 425                 430        
 Phe Ile
        



      <210> 1253
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 1253
 Met Arg Leu Trp Leu Leu Leu Ser Arg Val Pro Pro Gly Ser Leu His
   1               5                  10                  15    
 Ala Leu Pro Val Arg Gly Arg Asp Ala Asn Pro Ser Val Pro Thr Ala
              20                  25                  30        
 Asp Pro Glu Pro Gly Lys Thr Ala Pro Gly Ala Ser Arg Glu Leu Gly
          35                  40                  45            
 Ser Ser Gly Arg Gly Gly Arg Ser Ser Cys Gly Gly His Thr Leu Asp
      50                  55                  60                
 Glu Arg Leu Phe Cys Arg Gly
  65                  70    



      <210> 1254
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 1254
 Met Lys Ile Leu Glu Leu Ser Leu Lys Lys Gly Val His Met Leu Gln
   1               5                  10                  15    
 Cys Leu Cys Gly Arg Ser Leu Arg Ser Ser Asp Thr Pro Ser Glu Pro
              20                  25                  30        
 Gln Leu Lys Gly Ile Val Thr Arg Leu Cys Asn Arg Gln Gly Tyr Phe
          35                  40                  45            
 Leu Gln Met His Pro Asp Gly Thr Ile Asp Gly Thr Lys Asp Glu Asn
      50                  55                  60                
 Ser Asp Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg Val Val
  65                  70                  75                  80
 Ala Ile Gln Gly Val Lys Ala Ser Leu Tyr Val Ala Met Asn Gly Glu
                  85                  90                  95    
 Gly Tyr Leu Tyr Ser Ser Asp Val Phe Thr Pro Glu Cys Lys Phe Lys
             100                 105                 110        
 Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile Tyr Ser Ser Thr Leu Tyr
         115                 120                 125            
 Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe Leu Gly Leu Asn Lys Glu
     130                 135                 140                
 Gly Gln Ile Met Lys Gly Asn Arg Val Lys Lys Thr Lys Pro Ser Ser
 145                 150                 155                 160
 His Phe Val Pro Lys Pro Ile Glu Val Cys Met Tyr Arg Glu Pro Ser
                 165                 170                 175    
 Leu His Glu Ile Gly Glu Lys Gln Gly Arg Ser Arg Lys Ser Ser Gly
             180                 185                 190        
 Thr Pro Thr Met Asn Gly Gly Lys Val Val Asn Gln Asp Ser Thr
         195                 200                 205        



      <210> 1255
      <211> 190
      <212> PRT
      <213> Homo sapiens


      <400> 1255
 Met Ala Lys Ala Thr Thr Ile Lys Glu Ala Leu Ala Arg Trp Glu Glu
   1               5                  10                  15    
 Lys Thr Gly Gln Arg Pro Ser Glu Ala Lys Glu Ile Lys Leu Tyr Ala
              20                  25                  30        
 Gln Ile Pro Pro Ile Glu Lys Met Asp Ala Ser Leu Ser Met Leu Ala
          35                  40                  45            
 Asn Cys Glu Lys Leu Ser Leu Ser Thr Asn Cys Ile Glu Lys Ile Ala
      50                  55                  60                
 Asn Leu Asn Gly Leu Lys Asn Leu Arg Ile Leu Ser Leu Gly Arg Asn
  65                  70                  75                  80
 Asn Ile Lys Asn Leu Asn Gly Leu Glu Ala Val Gly Asp Thr Leu Glu
                  85                  90                  95    
 Glu Leu Trp Ile Ser Tyr Asn Phe Ile Glu Lys Leu Lys Gly Ile His
             100                 105                 110        
 Ile Met Lys Lys Leu Lys Ile Leu Tyr Met Ser Asn Asn Leu Val Lys
         115                 120                 125            
 Asp Trp Ala Glu Phe Val Lys Leu Ala Glu Leu Pro Cys Leu Glu Asp
     130                 135                 140                
 Leu Val Phe Val Gly Asn Pro Leu Glu Glu Lys His Ser Ala Glu Asn
 145                 150                 155                 160
 Asn Trp Ile Glu Glu Ala Thr Lys Arg Val Pro Lys Leu Lys Lys Leu
                 165                 170                 175    
 Asp Gly Thr Pro Val Ile Lys Gly Asp Glu Glu Glu Asp Asn
             180                 185                 190



      <210> 1256
      <211> 579
      <212> PRT
      <213> Homo sapiens


      <400> 1256
 Met Phe Phe Arg Val Phe Leu His Phe Ile Arg Ser His Ser Ala Thr
   1               5                  10                  15    
 Ala Val Asp Phe Leu Pro Val Met Val His Arg Leu Pro Val Phe Lys
              20                  25                  30        
 Arg Tyr Met Gly Asn Thr Pro Gln Lys Lys Ala Val Phe Gly Gln Cys
          35                  40                  45            
 Arg Gly Leu Pro Cys Val Ala Pro Leu Leu Thr Thr Val Glu Glu Ala
      50                  55                  60                
 Pro Arg Gly Ile Ser Ala Arg Val Trp Gly His Phe Pro Lys Trp Leu
  65                  70                  75                  80
 Asn Gly Ser Leu Leu Arg Ile Gly Pro Gly Lys Phe Glu Phe Gly Lys
                  85                  90                  95    
 Asp Lys Tyr Asn His Trp Phe Asp Gly Met Ala Leu Leu His Gln Phe
             100                 105                 110        
 Arg Met Ala Lys Gly Thr Val Thr Tyr Arg Ser Lys Phe Leu Gln Ser
         115                 120                 125            
 Asp Thr Tyr Lys Ala Asn Ser Ala Lys Asn Arg Ile Val Ile Ser Glu
     130                 135                 140                
 Phe Gly Thr Leu Ala Leu Pro Asp Pro Cys Lys Asn Val Phe Glu Arg
 145                 150                 155                 160
 Phe Met Ser Arg Phe Glu Leu Pro Gly Lys Ala Ala Ala Met Thr Asp
                 165                 170                 175    
 Asn Thr Asn Val Asn Tyr Val Arg Tyr Lys Gly Asp Tyr Tyr Leu Cys
             180                 185                 190        
 Thr Glu Thr Asn Phe Met Asn Lys Val Asp Ile Glu Thr Leu Glu Lys
         195                 200                 205            
 Thr Glu Lys Val Asp Trp Ser Lys Phe Ile Ala Val Asn Gly Ala Thr
     210                 215                 220                
 Ala His Pro His Tyr Asp Leu Asp Gly Thr Ala Tyr Asn Met Gly Asn
 225                 230                 235                 240
 Ser Phe Gly Pro Tyr Gly Phe Ser Tyr Lys Val Ile Arg Val Pro Pro
                 245                 250                 255    
 Glu Glu Val Asp Leu Gly Glu Thr Ile His Gly Val Gln Val Ile Cys
             260                 265                 270        
 Ser Ile Ala Ser Thr Glu Lys Gly Lys Pro Ser Tyr Tyr His Ser Phe
         275                 280                 285            
 Gly Met Thr Arg Asn Tyr Ile Ile Phe Ile Glu Gln Pro Leu Lys Met
     290                 295                 300                
 Asn Leu Trp Lys Ile Ala Thr Ser Lys Ile Arg Gly Lys Ala Phe Ser
 305                 310                 315                 320
 Asp Gly Ile Ser Trp Glu Pro Gln Cys Asn Thr Arg Phe His Val Val
                 325                 330                 335    
 Glu Lys Arg Thr Gly Gln Leu Leu Pro Gly Arg Tyr Tyr Ser Lys Pro
             340                 345                 350        
 Phe Val Thr Phe His Gln Ile Asn Ala Phe Glu Asp Gln Gly Cys Val
         355                 360                 365            
 Ile Ile Asp Leu Cys Cys Gln Asp Asn Gly Arg Thr Leu Glu Val Tyr
     370                 375                 380                
 Gln Leu Gln Asn Leu Arg Lys Ala Gly Glu Gly Leu Asp Gln Val His
 385                 390                 395                 400
 Asn Ser Ala Ala Lys Ser Phe Pro Arg Arg Phe Val Leu Pro Leu Asn
                 405                 410                 415    
 Val Ser Leu Asn Ala Pro Glu Gly Asp Asn Leu Ser Pro Leu Ser Tyr
             420                 425                 430        
 Thr Ser Ala Ser Ala Val Lys Gln Ala Asp Gly Thr Ile Cys Cys Ser
         435                 440                 445            
 His Glu Asn Leu His Gln Glu Asp Leu Glu Lys Glu Gly Gly Ile Glu
     450                 455                 460                
 Phe Pro Gln Ile Tyr Tyr Asp Arg Phe Ser Gly Lys Lys Tyr His Phe
 465                 470                 475                 480
 Phe Tyr Gly Cys Gly Phe Arg His Leu Val Gly Asp Ser Leu Ile Lys
                 485                 490                 495    
 Val Asp Val Val Asn Lys Thr Leu Lys Val Trp Arg Glu Asp Gly Phe
             500                 505                 510        
 Tyr Pro Ser Glu Pro Val Phe Val Pro Ala Pro Gly Thr Asn Glu Glu
         515                 520                 525            
 Asp Gly Gly Val Ile Leu Ser Val Val Ile Thr Pro Asn Gln Asn Glu
     530                 535                 540                
 Ser Asn Phe Leu Leu Val Leu Asp Ala Lys Asn Phe Glu Glu Leu Gly
 545                 550                 555                 560
 Arg Ala Glu Val Pro Val Gln Met Pro Tyr Gly Phe His Gly Thr Phe
                 565                 570                 575    
 Ile Pro Ile
            



      <210> 1257
      <211> 561
      <212> PRT
      <213> Homo sapiens


      <400> 1257
 Met Phe Phe Arg Val Phe Leu His Phe Ile Arg Ser His Ser Ala Thr
   1               5                  10                  15    
 Ala Val Asp Phe Leu Pro Val Met Val His Arg Leu Pro Val Phe Lys
              20                  25                  30        
 Arg Tyr Met Gly Asn Thr Pro Gln Asn Thr Val Glu Glu Ala Pro Arg
          35                  40                  45            
 Gly Ile Ser Ala Arg Val Trp Gly His Phe Pro Lys Trp Leu Asn Gly
      50                  55                  60                
 Ser Leu Leu Arg Ile Gly Pro Gly Lys Phe Glu Phe Gly Lys Asp Lys
  65                  70                  75                  80
 Tyr Asn His Trp Phe Asp Gly Met Ala Leu Leu His Gln Phe Arg Met
                  85                  90                  95    
 Ala Lys Gly Thr Val Thr Tyr Arg Ser Lys Phe Leu Gln Ser Asp Thr
             100                 105                 110        
 Tyr Lys Ala Asn Ser Ala Lys Asn Arg Ile Val Ile Ser Glu Phe Gly
         115                 120                 125            
 Thr Leu Ala Leu Pro Asp Pro Cys Lys Asn Val Phe Glu Arg Phe Met
     130                 135                 140                
 Ser Arg Phe Glu Leu Pro Gly Lys Ala Ala Ala Met Thr Asp Asn Thr
 145                 150                 155                 160
 Asn Val Asn Tyr Val Arg Tyr Lys Gly Asp Tyr Tyr Leu Cys Thr Glu
                 165                 170                 175    
 Thr Asn Phe Met Asn Lys Val Asp Ile Glu Thr Leu Glu Lys Thr Glu
             180                 185                 190        
 Lys Val Asp Trp Ser Lys Phe Ile Ala Val Asn Gly Ala Thr Ala His
         195                 200                 205            
 Pro His Tyr Asp Leu Asp Gly Thr Ala Tyr Asn Met Gly Asn Ser Phe
     210                 215                 220                
 Gly Pro Tyr Gly Phe Ser Tyr Lys Val Ile Arg Val Pro Pro Glu Glu
 225                 230                 235                 240
 Val Asp Leu Gly Glu Thr Ile His Gly Val Gln Val Ile Cys Ser Ile
                 245                 250                 255    
 Ala Ser Thr Glu Lys Gly Lys Pro Ser Tyr Tyr His Ser Phe Gly Met
             260                 265                 270        
 Thr Arg Asn Tyr Ile Ile Phe Ile Glu Gln Pro Leu Lys Met Asn Leu
         275                 280                 285            
 Trp Lys Ile Ala Thr Ser Lys Ile Arg Gly Lys Ala Phe Ser Asp Gly
     290                 295                 300                
 Ile Ser Trp Glu Pro Gln Cys Asn Thr Arg Phe His Val Val Glu Lys
 305                 310                 315                 320
 Arg Thr Gly Gln Leu Leu Pro Gly Arg Tyr Tyr Ser Lys Pro Phe Val
                 325                 330                 335    
 Thr Phe His Gln Ile Asn Ala Phe Glu Asp Gln Gly Cys Val Ile Ile
             340                 345                 350        
 Asp Leu Cys Cys Gln Asp Asn Gly Arg Thr Leu Glu Val Tyr Gln Leu
         355                 360                 365            
 Gln Asn Leu Arg Lys Ala Gly Glu Gly Leu Asp Gln Val His Asn Ser
     370                 375                 380                
 Ala Ala Lys Ser Phe Pro Arg Arg Phe Val Leu Pro Leu Asn Val Ser
 385                 390                 395                 400
 Leu Asn Ala Pro Glu Gly Asp Asn Leu Ser Pro Leu Ser Tyr Thr Ser
                 405                 410                 415    
 Ala Ser Ala Val Lys Gln Ala Asp Gly Thr Ile Cys Cys Ser His Glu
             420                 425                 430        
 Asn Leu His Gln Glu Asp Leu Glu Lys Glu Gly Gly Ile Glu Phe Pro
         435                 440                 445            
 Gln Ile Tyr Tyr Asp Arg Phe Ser Gly Lys Lys Tyr His Phe Phe Tyr
     450                 455                 460                
 Gly Cys Gly Phe Arg His Leu Val Gly Asp Ser Leu Ile Lys Val Asp
 465                 470                 475                 480
 Val Val Asn Lys Thr Leu Lys Val Trp Arg Glu Asp Gly Phe Tyr Pro
                 485                 490                 495    
 Ser Glu Pro Val Phe Val Pro Ala Pro Gly Thr Asn Glu Glu Asp Gly
             500                 505                 510        
 Gly Val Ile Leu Ser Val Val Ile Thr Pro Asn Gln Asn Glu Ser Asn
         515                 520                 525            
 Phe Leu Leu Val Leu Asp Ala Lys Asn Phe Glu Glu Leu Gly Arg Ala
     530                 535                 540                
 Glu Val Pro Val Gln Met Pro Tyr Gly Phe His Gly Thr Phe Ile Pro
 545                 550                 555                 560
 Ile
    



      <210> 1258
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 1258
 Met Gln Met Gly Arg Phe Leu Leu Leu Val Ile Leu Phe Leu Pro Arg
   1               5                  10                  15    
 Glu Met Thr Ser Ser Val Leu Thr Val Asn Gly Lys Thr Glu Asn Tyr
              20                  25                  30        
 Ile Leu Asp Thr Thr Pro Gly Ser Gln Ala Ser Leu Ile Cys Ala Val
          35                  40                  45            
 Gln Asn His Thr Arg Glu Glu Glu Leu Leu Trp Tyr Arg Glu Glu Gly
      50                  55                  60                
 Arg Val Asp Leu Lys Ser Gly Asn Lys Ile Asn Ser Ser Ser Val Cys
  65                  70                  75                  80
 Val Ser Ser Ile Ser Glu Asn Asp Asn Gly Ile Ser Phe Thr Cys Arg
                  85                  90                  95    
 Leu Gly Arg Asp Gln Ser Val Ser Val Ser Val Val Leu Asn Val Thr
             100                 105                 110        
 Phe Pro Pro Leu Leu Ser Gly Asn Asp Phe Gln Thr Val Glu Glu Gly
         115                 120                 125            
 Ser Asn Leu Lys Leu Val Cys Asn Val Lys Ala Asn Pro Gln Ala Gln
     130                 135                 140                
 Met Met Trp Tyr Lys Asn Ser Ser Leu Leu Asp Leu Glu Lys Ser Arg
 145                 150                 155                 160
 His Gln Ile Gln Gln Thr Ser Glu Ser Phe Gln Leu Ser Ile Thr Lys
                 165                 170                 175    
 Val Glu Lys Pro Asp Asn Gly Thr Tyr Ser Cys Met Ala Lys Ser Ser
             180                 185                 190        
 Leu Lys Thr Glu Ser Leu Asp Phe His Leu Ile Val Lys Asp Lys Thr
         195                 200                 205            
 Val Gly Val Pro Ile Glu Pro Ile Ile Ala Ala Cys Val Val Ile Phe
     210                 215                 220                
 Leu Thr Leu Cys Leu Asp
 225                 230



      <210> 1259
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 1259
 Met Arg Asn Leu Val Ser Gly Ser Leu Gly Met Phe Val Ala Leu Trp
   1               5                  10                  15    
 Met Lys Trp Leu Lys Pro Ala Leu Ser Leu Ser Pro Ser Ser Trp Gly
              20                  25                  30        
 His Thr Ser Leu Gln Lys Arg Met Trp Gln Phe Pro Pro Gln Gln Gln
          35                  40                  45            
 Pro Ala Gly Ala Ser Ser Asp Ser Pro Leu Glu Glu Val Ser Ser Ser
      50                  55                  60                
 Leu His Ser Arg
  65            



      <210> 1260
      <211> 281
      <212> PRT
      <213> Homo sapiens


      <400> 1260
 Met Met Glu Gln Glu Met Thr Arg Leu His Arg Arg Val Ser Glu Val
   1               5                  10                  15    
 Glu Ala Val Leu Ser Gln Lys Glu Val Glu Leu Lys Ala Ser Glu Thr
              20                  25                  30        
 Gln Arg Ser Leu Leu Glu Gln Asp Leu Ala Thr Tyr Ile Thr Glu Cys
          35                  40                  45            
 Ser Ser Leu Lys Arg Ser Leu Glu Gln Ala Arg Met Glu Val Ser Gln
      50                  55                  60                
 Glu Asp Asp Lys Ala Leu Gln Leu Leu His Asp Ile Arg Glu Gln Ser
  65                  70                  75                  80
 Arg Lys Leu Gln Glu Ile Lys Glu Gln Glu Tyr Gln Ala Gln Val Glu
                  85                  90                  95    
 Glu Met Arg Leu Met Met Asn Gln Leu Glu Glu Asp Leu Val Ser Ala
             100                 105                 110        
 Arg Arg Arg Ser Asp Leu Tyr Glu Ser Glu Leu Arg Glu Ser Arg Leu
         115                 120                 125            
 Ala Ala Glu Glu Phe Lys Arg Lys Ala Thr Glu Cys Gln His Lys Leu
     130                 135                 140                
 Leu Lys Ala Lys Asp Gln Gly Lys Pro Glu Val Gly Glu Tyr Ala Lys
 145                 150                 155                 160
 Leu Glu Lys Ile Asn Ala Glu Gln Gln Leu Lys Ile Gln Glu Leu Gln
                 165                 170                 175    
 Glu Lys Leu Glu Lys Ala Val Lys Ala Ser Thr Glu Ala Thr Glu Leu
             180                 185                 190        
 Leu Gln Asn Ile Arg Gln Ala Lys Glu Arg Ala Glu Arg Glu Leu Glu
         195                 200                 205            
 Lys Leu Gln Asn Arg Glu Asp Ser Ser Glu Gly Ile Arg Lys Lys Leu
     210                 215                 220                
 Val Glu Ala Glu Glu Arg Arg His Ser Leu Glu Asn Lys Val Lys Arg
 225                 230                 235                 240
 Leu Glu Thr Met Glu Arg Arg Glu Asn Arg Leu Lys Asp Asp Ile Gln
                 245                 250                 255    
 Thr Lys Ser Gln Gln Ile Gln Gln Met Ala Asp Lys Ile Leu Val Ser
             260                 265                 270        
 Arg Asn Glu Ser Arg Lys Val Lys Arg
         275                 280    



      <210> 1261
      <211> 423
      <212> PRT
      <213> Homo sapiens


      <400> 1261
 Met Pro Pro Phe Leu Ile Thr Leu Phe Leu Phe His Ser Cys Cys Leu
   1               5                  10                  15    
 Arg Ala Asn Gly His Leu Arg Glu Gly Met Thr Leu Leu Lys Thr Glu
              20                  25                  30        
 Phe Ala Leu His Leu Tyr Gln Ser Val Ala Ala Cys Arg Asn Glu Thr
          35                  40                  45            
 Asn Phe Val Ile Ser Pro Ala Gly Val Ser Leu Pro Leu Glu Ile Leu
      50                  55                  60                
 Gln Phe Gly Ala Glu Gly Ser Thr Gly Gln Gln Leu Ala Asp Ala Leu
  65                  70                  75                  80
 Gly Tyr Thr Val His Ala His Pro Ala Ala Gln Ala Thr Trp Glu Ile
                  85                  90                  95    
 Gly Ser Ser Ala Pro Tyr Gly Val His Met Gly Lys Ser Asp His Trp
             100                 105                 110        
 Thr Asp Lys Arg Val Lys Asp Phe Leu His Ala Val Tyr Ala Thr Leu
         115                 120                 125            
 Pro Thr Ser Ser Gln Gly Thr Glu Met Glu Leu Ala Cys Ser Leu Phe
     130                 135                 140                
 Val Gln Val Gly Thr Pro Leu Ser Pro Cys Phe Val Glu His Val Ser
 145                 150                 155                 160
 Trp Trp Ala Asn Ser Ser Leu Glu Pro Ala Asp Leu Ser Glu Pro Asn
                 165                 170                 175    
 Ser Thr Ala Ile Gln Thr Ser Glu Gly Ala Ser Arg Glu Thr Ala Gly
             180                 185                 190        
 Gly Gly Pro Ser Glu Gly Pro Gly Gly Trp Pro Trp Glu Gln Val Ser
         195                 200                 205            
 Ala Ala Phe Ala Gln Leu Val Leu Val Ser Thr Met Ser Phe Gln Gly
     210                 215                 220                
 Thr Trp Arg Lys Arg Phe Ser Ser Thr Asp Thr Gln Ile Leu Pro Phe
 225                 230                 235                 240
 Thr Cys Ala Tyr Gly Leu Val Leu Gln Val Pro Met Met His Gln Thr
                 245                 250                 255    
 Thr Glu Val Asn Tyr Gly Gln Phe Gln Asp Thr Ala Gly His Gln Val
             260                 265                 270        
 Gly Val Leu Glu Leu Pro Tyr Leu Gly Ser Ala Val Ser Leu Phe Leu
         275                 280                 285            
 Val Leu Pro Arg Asp Lys Asp Thr Pro Leu Ser His Ile Glu Pro His
     290                 295                 300                
 Leu Thr Ala Ser Thr Ile His Leu Trp Thr Thr Ser Leu Arg Arg Ala
 305                 310                 315                 320
 Arg Met Asp Val Phe Leu Pro Arg Phe Arg Ile Gln Asn Gln Phe Asn
                 325                 330                 335    
 Leu Lys Ser Ile Leu Asn Ser Trp Gly Val Thr Asp Leu Phe Asp Pro
             340                 345                 350        
 Leu Lys Ala Asn Leu Lys Gly Ile Ser Gly Gln Asp Gly Phe Tyr Val
         355                 360                 365            
 Ser Glu Ala Ile His Lys Ala Lys Ile Glu Val Leu Glu Glu Gly Thr
     370                 375                 380                
 Lys Ala Ser Gly Ala Thr Ala Leu Leu Leu Leu Lys Arg Ser Arg Ile
 385                 390                 395                 400
 Pro Ile Phe Lys Ala Asp Arg Pro Phe Ile Tyr Phe Leu Arg Glu Pro
                 405                 410                 415    
 Asn Thr Ala Phe Leu Ser Phe
             420            



      <210> 1262
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 1262
 Met Val Val Gly Ile Leu Leu Glu Val Ile Ala Ile Phe Val Ala Thr
   1               5                  10                  15    
 Val Gly Met Lys Cys Met Lys Cys Leu Glu Asp Asp Glu Val Gln Lys
              20                  25                  30        
 Met Arg Met Ala Val Ile Gly Gly Ala Ile Phe Leu Leu Ala Gly Asn
          35                  40                  45            
 Arg Gly Cys Gly Pro Leu Ser Pro Tyr
      50                  55        



      <210> 1263
      <211> 208
      <212> PRT
      <213> Homo sapiens


      <400> 1263
 Met Ser Phe Ile Cys Glu Trp Ile Tyr Asn Gly Phe Tyr Ser Val Leu
   1               5                  10                  15    
 Gln Phe Leu Gly Leu Tyr Lys Lys Ser Arg Lys Leu Val Leu Leu Gly
              20                  25                  30        
 Trp Asp Asn Val Asp Glu Thr Ile Leu Pro His Met Leu Lys Asp Gly
          35                  40                  45            
 Gly Leu Gly Gln Gln Ala Pro Thr Arg Pro Leu Pro Ser Ala Glu Leu
      50                  55                  60                
 Thr Thr Ala Ser Leu Ala Phe Thr Thr Phe Asp Leu Leu Gly His Lys
  65                  70                  75                  80
 Gln Thr Arg Trp Ile Trp Asn Ser Asp Leu Pro Ala Thr Asn Gly Ile
                  85                  90                  95    
 Ala Phe Leu Gly Tyr Cys Ala Asp Cys Pro Gln Ile Leu Glu Ser Lys
             100                 105                 110        
 Glu Glu Leu Asn Ala Leu Met Thr Asp Glu Arg Ile Ser His Val Pro
         115                 120                 125            
 Val Leu Ile Leu Ile Ser Lys His Trp Thr Glu Gln Ala Gln Ser Val
     130                 135                 140                
 Lys Lys Asn Ser Val Cys His Leu Val Phe Met Asp Arg Pro Gln Glu
 145                 150                 155                 160
 Arg Glu Leu Val Thr Leu Lys Glu Pro Asn Ala Phe Ser Lys Glu Ser
                 165                 170                 175    
 Phe Thr Leu Ser Val Tyr Asn Asn Arg Ala Met Ala Arg Ala Ser Ala
             180                 185                 190        
 Gly Leu Pro Ser Ile Leu Thr Asp Gly Trp Ala Val Lys Ile Lys Val
         195                 200                 205            





      <210> 1264
      <211> 399
      <212> PRT
      <213> Homo sapiens


      <400> 1264
 Met Ala Glu Leu Leu Arg Ser Leu Gln Asp Ser Gln Leu Val Ala Arg
   1               5                  10                  15    
 Phe Gln Arg Arg Cys Gly Leu Phe Pro Ala Pro Asp Glu Gly Pro Arg
              20                  25                  30        
 Glu Asn Gly Ala Asp Pro Thr Glu Arg Ala Ala Arg Val Pro Gly Val
          35                  40                  45            
 Glu His Leu Pro Ala Ala Asn Gly Lys Gly Gly Glu Ala Pro Ala Asn
      50                  55                  60                
 Gly Leu Arg Arg Ala Ala Ala Pro Glu Ala Tyr Val Gln Lys Tyr Val
  65                  70                  75                  80
 Val Lys Asn Tyr Phe Tyr Tyr Tyr Leu Phe Gln Phe Ser Ala Ala Leu
                  85                  90                  95    
 Gly Gln Glu Val Phe Tyr Ile Thr Phe Leu Pro Phe Thr His Trp Asn
             100                 105                 110        
 Ile Asp Pro Tyr Leu Ser Arg Arg Leu Ile Ile Ile Trp Val Leu Val
         115                 120                 125            
 Met Tyr Ile Gly Gln Val Ala Lys Asp Val Leu Lys Trp Pro Arg Pro
     130                 135                 140                
 Ser Ser Pro Pro Val Val Lys Leu Glu Lys Arg Leu Ile Ala Glu Tyr
 145                 150                 155                 160
 Gly Met Pro Ser Thr His Ala Met Ala Ala Thr Ala Ile Ala Phe Thr
                 165                 170                 175    
 Leu Leu Ile Ser Thr Met Asp Arg Tyr Gln Tyr Pro Phe Val Leu Gly
             180                 185                 190        
 Leu Val Met Ala Val Val Phe Ser Thr Leu Val Cys Leu Ser Arg Leu
         195                 200                 205            
 Tyr Thr Gly Met His Thr Val Leu Asp Val Leu Gly Gly Val Leu Ile
     210                 215                 220                
 Thr Ala Leu Leu Ile Val Leu Thr Tyr Pro Ala Trp Thr Phe Ile Asp
 225                 230                 235                 240
 Cys Leu Asp Ser Ala Ser Pro Leu Phe Pro Val Cys Val Ile Val Val
                 245                 250                 255    
 Pro Phe Phe Leu Cys Tyr Asn Tyr Pro Val Ser Asp Tyr Tyr Ser Pro
             260                 265                 270        
 Thr Arg Ala Asp Thr Thr Thr Ile Leu Ala Ala Gly Ala Gly Val Thr
         275                 280                 285            
 Ile Gly Phe Trp Ile Asn His Phe Phe Gln Leu Val Ser Lys Pro Ala
     290                 295                 300                
 Glu Ser Leu Pro Val Ile Gln Asn Ile Pro Pro Leu Thr Thr Tyr Met
 305                 310                 315                 320
 Leu Val Leu Gly Leu Thr Lys Phe Ala Val Gly Ile Val Leu Ile Leu
                 325                 330                 335    
 Leu Val Arg Gln Leu Val Gln Asn Leu Ser Leu Gln Val Leu Tyr Ser
             340                 345                 350        
 Trp Phe Lys Val Val Thr Arg Asn Lys Glu Ala Arg Arg Arg Leu Glu
         355                 360                 365            
 Ile Glu Val Pro Tyr Lys Phe Val Thr Tyr Thr Ser Val Gly Ile Cys
     370                 375                 380                
 Ala Thr Thr Phe Val Pro Met Leu His Arg Phe Leu Gly Leu Pro
 385                 390                 395                



      <210> 1265
      <211> 692
      <212> PRT
      <213> Homo sapiens


      <400> 1265
 Met Arg Ala Ala Leu Trp Thr Leu Gly Leu Gly Pro Leu Leu Leu Asn
   1               5                  10                  15    
 Leu Trp Ala Val Ser Val Gly Gly Pro Gly Ala Leu Arg Leu Ala Tyr
              20                  25                  30        
 Arg His Ser Thr Cys Asp Gly Val Val Leu Val Arg His His Gly Ala
          35                  40                  45            
 Trp Gly Tyr Val Cys Asn Gln Glu Trp Thr Leu Ala Glu Ala Ser Val
      50                  55                  60                
 Val Cys Arg Gln Leu Gly Cys Gly Pro Ala Val Gly Ala Pro Lys Tyr
  65                  70                  75                  80
 Val Pro Leu Pro Gly Glu Met Ala Gln Pro Trp Leu His Asn Val Ser
                  85                  90                  95    
 Cys Arg Gly Asn Glu Ser Ser Leu Trp Glu Cys Ser Leu Gly Ser Trp
             100                 105                 110        
 Cys Gln Ser Pro Cys Pro His Ala Trp Val Val Val Ala Leu Cys Ser
         115                 120                 125            
 Arg His Thr Glu Ala Arg Leu Val Gly Gly Glu His Pro Cys Ala Gly
     130                 135                 140                
 Arg Leu Glu Val Thr Trp Gly Thr Val Cys Asp Ala Ala Leu Asp Leu
 145                 150                 155                 160
 Ala Thr Ala His Val Val Cys Arg Glu Leu Gln Cys Gly Ala Val Val
                 165                 170                 175    
 Ser Thr Pro Glu Gly Ala Arg Phe Gly Arg Gly Ser Gly Pro Val Trp
             180                 185                 190        
 Thr Glu Ala Phe Arg Cys Ala Gly Asn Glu Ser Leu Leu Phe His Cys
         195                 200                 205            
 Pro Arg Gly Arg Gly Ser Gln Cys Gly His Gly His Asp Ala Gly Leu
     210                 215                 220                
 Arg Cys Ser Glu Phe Arg Met Val Asn Gly Ser Ser Ser Cys Glu Gly
 225                 230                 235                 240
 Arg Val Glu Phe Gln Val Gln Gly Ser Trp Ala Pro Leu Cys Ala Thr
                 245                 250                 255    
 His Trp Asp Ile Ala Asp Ala Thr Val Leu Cys His Gln Leu Asn Cys
             260                 265                 270        
 Gly Asn Ala Val Ala Ala Pro Gly Gly Gly His Phe Gly Asp Gly Asp
         275                 280                 285            
 Ala Ala Ile Trp Pro Asp Ala Phe His Cys Glu Gly Thr Glu Ser Tyr
     290                 295                 300                
 Leu Trp Asn Cys Pro Val Ser Thr Leu Gly Ala Pro Ala Cys Ala Pro
 305                 310                 315                 320
 Gly Asn Thr Ala Ser Ala Val Cys Ser Gly Gly Cys Ser Gln Asp Gly
                 325                 330                 335    
 Gly Pro Gly Gly Gln Gly Thr Pro Trp Pro Asp Cys Ala Cys Leu Ala
             340                 345                 350        
 Glu Ser Val Ala Leu Arg Leu Arg Gly Gly Thr Cys Cys Cys Ala Gly
         355                 360                 365            
 Trp Leu Asp Val Phe Tyr Asn Gly Thr Trp Gly Ala Met Cys Ser Asn
     370                 375                 380                
 Ala Leu Lys Asp Leu Ser Leu Ser Ile Ile Cys Lys Gln Leu Gly Cys
 385                 390                 395                 400
 Gly Gly Glu Trp Gly Trp Leu Glu Asn Arg Pro Phe Pro Ser Ala Gly
                 405                 410                 415    
 Thr Gly Thr Ala Trp Val Asp Asn Ile Glu Cys Arg Arg Leu Pro Asn
             420                 425                 430        
 Ser Thr Leu Trp Gln Cys Pro Ser His Pro Trp His Pro His Ser Cys
         435                 440                 445            
 Asp Leu Arg Glu Gln Val Trp Ile Thr Cys Ala Ala Pro Ala Val Thr
     450                 455                 460                
 Ala Ala Pro Phe Ala Glu Glu Gly Ala Leu Arg Val Arg Gly Gly Glu
 465                 470                 475                 480
 Asp Arg Cys Ser Gly Arg Val Glu Leu Trp His Ala Gly Ser Trp Gly
                 485                 490                 495    
 Thr Val Cys Asp Asp Gly Trp Asp Leu Ala Asp Ala Glu Val Val Cys
             500                 505                 510        
 Arg Gln Leu Gly Cys Gly Arg Ala Val Ala Ala Leu Gly Ala Ala Ala
         515                 520                 525            
 Phe Gly Pro Gly Ser Gly Pro Val Trp Leu Asp Glu Val Gly Cys Arg
     530                 535                 540                
 Gly Ser Glu Ala Ser Leu Trp Gly Cys Pro Ala Glu Arg Trp Gly Arg
 545                 550                 555                 560
 Gly Asp Arg Ala His Glu Glu Asp Ala Gly Val Arg Cys Trp Ala Pro
                 565                 570                 575    
 Phe Arg Thr Phe Trp Val Val Ser Val Val Leu Gly Ser Leu Leu Gly
             580                 585                 590        
 Leu Leu Leu Leu Gly Leu Met Ala Phe Leu Ile Leu Pro Arg Val Thr
         595                 600                 605            
 Gln Ala Met Gln Arg Gly Leu Gly Arg Ser Glu Val Ser Pro Gly Glu
     610                 615                 620                
 Ala Ile Tyr Asp Val Ile Gly Glu Met Pro Leu Ala Gly Leu Tyr Glu
 625                 630                 635                 640
 Glu Ile Met Glu Ala Glu Ala Val Leu Gln Asp Glu Glu Asp Gly Ser
                 645                 650                 655    
 Val Val Lys Val Asp Thr Glu Ala Ala Val Ser Gly Glu Val Ser Asn
             660                 665                 670        
 Leu Leu Glu Gly Gln Ser Ile Arg Ala Glu Gly Gly His Ser Arg Pro
         675                 680                 685            
 Val Ser Gln Gly
     690        



      <210> 1266
      <211> 675
      <212> PRT
      <213> Homo sapiens


      <400> 1266
 Met Arg Ala Ala Leu Trp Thr Leu Gly Leu Gly Pro Leu Leu Leu Asn
   1               5                  10                  15    
 Leu Trp Ala Val Ser Val Gly Gly Pro Gly Ala Leu Arg Leu Ala Tyr
              20                  25                  30        
 Arg His Ser Thr Cys Asp Gly Val Val Leu Val Arg His His Gly Ala
          35                  40                  45            
 Trp Gly Tyr Val Cys Asn Gln Glu Trp Thr Leu Ala Glu Ala Ser Val
      50                  55                  60                
 Val Cys Arg Gln Leu Gly Cys Gly Pro Ala Val Gly Ala Pro Lys Tyr
  65                  70                  75                  80
 Val Pro Leu Pro Gly Glu Met Ala Gln Pro Trp Leu His Asn Val Ser
                  85                  90                  95    
 Cys Arg Gly Asn Glu Ser Ser Leu Trp Glu Cys Ser Leu Gly Ser Trp
             100                 105                 110        
 Cys Gln Ser Pro Cys Pro His Ala Trp Val Val Val Ala Leu Cys Ser
         115                 120                 125            
 Arg His Thr Glu Ala Arg Leu Val Gly Gly Glu His Pro Cys Ala Gly
     130                 135                 140                
 Arg Leu Glu Val Thr Trp Gly Thr Val Cys Asp Ala Ala Leu Asp Leu
 145                 150                 155                 160
 Ala Thr Ala His Val Val Cys Arg Glu Leu Gln Cys Gly Ala Val Val
                 165                 170                 175    
 Ser Thr Pro Glu Gly Ala Arg Phe Gly Arg Gly Ser Gly Pro Val Trp
             180                 185                 190        
 Thr Glu Ala Phe Arg Cys Ala Gly Asn Glu Ser Leu Leu Phe His Cys
         195                 200                 205            
 Pro Arg Gly Arg Gly Ser Gln Cys Gly His Gly His Asp Ala Gly Leu
     210                 215                 220                
 Arg Cys Ser Glu Phe Arg Met Val Asn Gly Ser Ser Ser Cys Glu Gly
 225                 230                 235                 240
 Arg Val Glu Phe Gln Val Gln Gly Ser Trp Ala Pro Leu Cys Ala Thr
                 245                 250                 255    
 His Trp Asp Ile Ala Asp Ala Thr Val Leu Cys His Gln Leu Asn Cys
             260                 265                 270        
 Gly Asn Ala Val Ala Ala Pro Gly Gly Gly His Phe Gly Asp Gly Asp
         275                 280                 285            
 Ala Ala Ile Trp Pro Asp Ala Phe His Cys Glu Gly Thr Glu Ser Tyr
     290                 295                 300                
 Leu Trp Asn Cys Pro Val Ser Thr Leu Gly Ala Pro Ala Cys Ala Pro
 305                 310                 315                 320
 Gly Asn Thr Ala Ser Ala Val Cys Ser Gly Gly Cys Ser Gln Asp Gly
                 325                 330                 335    
 Gly Pro Gly Gly Gln Gly Thr Pro Trp Pro Asp Cys Ala Cys Leu Ala
             340                 345                 350        
 Glu Ser Val Ala Leu Arg Leu Arg Gly Gly Thr Cys Cys Cys Ala Gly
         355                 360                 365            
 Trp Leu Asp Val Phe Tyr Asn Gly Thr Trp Gly Ala Met Cys Ser Asn
     370                 375                 380                
 Ala Leu Lys Asp Leu Ser Leu Ser Ile Ile Cys Lys Gln Leu Gly Cys
 385                 390                 395                 400
 Gly Gly Glu Trp Gly Trp Leu Glu Asn Arg Pro Phe Pro Ser Ala Gly
                 405                 410                 415    
 Thr Gly Thr Ala Trp Val Asp Asn Ile Glu Cys Arg Arg Leu Pro Asn
             420                 425                 430        
 Ser Thr Leu Trp Gln Cys Pro Ser His Pro Trp His Pro His Ser Cys
         435                 440                 445            
 Asp Leu Arg Glu Gln Val Trp Ile Thr Cys Ala Ala Pro Ala Val Thr
     450                 455                 460                
 Ala Ala Pro Phe Ala Glu Glu Gly Ala Leu Arg Val Arg Gly Gly Glu
 465                 470                 475                 480
 Asp Arg Cys Ser Gly Arg Val Glu Leu Trp His Ala Gly Ser Trp Gly
                 485                 490                 495    
 Thr Val Cys Asp Asp Gly Trp Asp Leu Ala Asp Ala Glu Val Val Cys
             500                 505                 510        
 Arg Gln Leu Gly Cys Gly Arg Ala Val Ala Ala Leu Gly Ala Ala Ala
         515                 520                 525            
 Phe Gly Pro Gly Ser Gly Pro Val Trp Leu Asp Glu Val Gly Cys Arg
     530                 535                 540                
 Gly Ser Glu Ala Ser Leu Trp Gly Cys Pro Ala Glu Arg Trp Gly Arg
 545                 550                 555                 560
 Gly Asp Arg Ala His Glu Glu Asp Ala Gly Val Arg Cys Trp Ala Pro
                 565                 570                 575    
 Phe Arg Thr Phe Trp Val Val Ser Val Val Leu Gly Ser Leu Leu Gly
             580                 585                 590        
 Leu Leu Leu Leu Gly Leu Met Ala Phe Leu Ile Leu Pro Arg Val Thr
         595                 600                 605            
 Gln Ala Met Gln Arg Gly Leu Gly Arg Ser Glu Val Ser Pro Gly Glu
     610                 615                 620                
 Ala Ile Tyr Asp Val Ile Gly Glu Met Pro Leu Ala Gly Leu Tyr Glu
 625                 630                 635                 640
 Glu Ile Met Glu Ala Glu Ala Val Leu Gln Asp Glu Glu Asp Gly Ser
                 645                 650                 655    
 Val Val Lys Val Asp Thr Glu Ala Ala Gly Cys Leu Phe Thr Leu Met
             660                 665                 670        
 Thr Tyr Gln
         675



      <210> 1267
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 1267
 Met Leu Ser Ala Phe Gln Arg Leu Phe Arg Val Leu Phe Val Ile Glu
   1               5                  10                  15    
 Thr Val Ser Glu Tyr Gly Val Leu Ile Phe Ile Tyr Gly Trp Pro Phe
              20                  25                  30        
 Leu Gln Thr Leu Ala Met Leu Leu Ile Gly Thr Val Ser Phe His Leu
          35                  40                  45            
 Trp Ile Arg Arg Asn Arg Glu Arg Asn Ser Arg Ser Gly Lys Thr Arg
      50                  55                  60                
 Cys Arg Ser Lys Arg
  65                



      <210> 1268
      <211> 140
      <212> PRT
      <213> Homo sapiens


      <400> 1268
 Met Arg Ser Pro Arg Met Arg Val Cys Ala Lys Ser Val Leu Leu Ser
   1               5                  10                  15    
 His Trp Leu Phe Leu Ala Tyr Val Leu Met Val Cys Cys Lys Leu Met
              20                  25                  30        
 Ser Ala Ser Ser Gln His Leu Arg Gly His Ala Gly His His Gln Ile
          35                  40                  45            
 Lys Gln Gly Thr Cys Glu Val Val Ala Val His Arg Cys Cys Asn Lys
      50                  55                  60                
 Asn Arg Ile Glu Glu Arg Ser Gln Thr Val Lys Cys Ser Cys Phe Pro
  65                  70                  75                  80
 Gly Gln Val Ala Gly Thr Thr Arg Ala Gln Pro Ser Cys Val Glu Ala
                  85                  90                  95    
 Ser Ile Val Ile Gln Lys Trp Trp Cys His Met Asn Pro Cys Leu Glu
             100                 105                 110        
 Gly Glu Asp Cys Lys Val Leu Pro Asp Tyr Ser Gly Trp Ser Cys Ser
         115                 120                 125            
 Ser Gly Asn Lys Val Lys Thr Thr Lys Val Thr Arg
     130                 135                 140



      <210> 1269
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 1269
 Met Ile Leu Gly Ser Leu Ala Phe Tyr Leu Val Gln Leu Thr Gly Ser
   1               5                  10                  15    
 Glu Thr Gly Gln Ala Ser Arg Leu Arg Ser Ser Pro Gln Ala Arg Gln
              20                  25                  30        
 Ser Gly Lys Asp Glu Thr His Ser Asp Pro Thr Gly Arg Glu Ala Cys
          35                  40                  45            
 Glu Ala Asp Ser Thr Trp Ala His Leu Glu Arg Ser Glu Glu Lys Thr
      50                  55                  60                
 Thr Asn Leu Leu Gly Gln Lys Lys
  65                  70        



      <210> 1270
      <211> 814
      <212> PRT
      <213> Homo sapiens


      <400> 1270
 Met Leu Arg Arg Leu Asn Thr Ser Ile Gln Glu Lys Leu Arg Val Gln
   1               5                  10                  15    
 Phe Ser Thr Asp Ser Arg Val Gln Lys Met Phe Glu Ile Leu Leu Asp
              20                  25                  30        
 Glu Asn Ser Glu Ala Asp Lys Arg Glu Lys Ala Ala Asn Asn Leu Ile
          35                  40                  45            
 Val Leu Gly Arg Glu Glu Ala Gly Ala Glu Lys Ile Phe Gln Asn Asn
      50                  55                  60                
 Gly Val Ala Leu Leu Leu Gln Leu Leu Asp Thr Lys Lys Pro Glu Leu
  65                  70                  75                  80
 Val Leu Ala Ala Val Arg Thr Leu Ser Gly Met Cys Ser Gly His Gln
                  85                  90                  95    
 Ala Arg Ala Thr Val Ile Leu His Ala Val Arg Ile Asp Arg Ile Cys
             100                 105                 110        
 Ser Leu Met Ala Val Glu Asn Glu Glu Met Ser Leu Ala Val Cys Asn
         115                 120                 125            
 Leu Leu Gln Ala Ile Ile Asp Ser Leu Ser Gly Glu Asp Lys Arg Glu
     130                 135                 140                
 His Arg Gly Lys Glu Glu Ala Leu Val Leu Asp Thr Lys Lys Asp Leu
 145                 150                 155                 160
 Lys Gln Ile Thr Ser His Leu Leu Asp Met Leu Val Ser Lys Lys Val
                 165                 170                 175    
 Ser Gly Gln Gly Arg Asp Gln Ala Leu Asn Leu Leu Asn Lys Asn Val
             180                 185                 190        
 Pro Arg Lys Asp Leu Ala Ile His Asp Asn Ser Arg Thr Ile Tyr Val
         195                 200                 205            
 Val Asp Asn Gly Leu Arg Lys Ile Leu Lys Val Val Gly Gln Val Pro
     210                 215                 220                
 Asp Leu Pro Ser Cys Leu Pro Leu Thr Asp Asn Thr Arg Met Leu Ala
 225                 230                 235                 240
 Ser Ile Leu Ile Asn Lys Leu Tyr Asp Asp Leu Arg Cys Asp Pro Glu
                 245                 250                 255    
 Arg Asp His Phe Arg Lys Ile Cys Glu Glu Tyr Ile Thr Gly Lys Phe
             260                 265                 270        
 Asp Pro Gln Asp Met Asp Lys Asn Leu Asn Ala Ile Gln Thr Val Ser
         275                 280                 285            
 Gly Ile Leu Gln Gly Pro Phe Asp Leu Gly Asn Gln Leu Leu Gly Leu
     290                 295                 300                
 Lys Gly Val Met Glu Met Met Val Ala Leu Cys Gly Ser Glu Arg Glu
 305                 310                 315                 320
 Thr Asp Gln Leu Val Ala Val Glu Ala Leu Ile His Ala Ser Thr Lys
                 325                 330                 335    
 Leu Ser Arg Ala Thr Phe Ile Ile Thr Asn Gly Val Ser Leu Leu Lys
             340                 345                 350        
 Gln Ile Tyr Lys Thr Thr Lys Asn Glu Lys Ile Lys Ile Arg Thr Leu
         355                 360                 365            
 Val Gly Leu Cys Lys Leu Gly Ser Ala Gly Gly Thr Asp Tyr Gly Leu
     370                 375                 380                
 Arg Gln Phe Ala Glu Gly Ser Thr Glu Lys Leu Ala Lys Gln Cys Arg
 385                 390                 395                 400
 Lys Trp Leu Cys Asn Met Ser Ile Asp Thr Arg Thr Arg Arg Trp Ala
                 405                 410                 415    
 Val Glu Gly Leu Ala Tyr Leu Thr Leu Asp Ala Asp Val Lys Asp Asp
             420                 425                 430        
 Phe Val Gln Asp Val Pro Ala Leu Gln Ala Met Phe Glu Leu Ala Lys
         435                 440                 445            
 Thr Ser Asp Lys Thr Ile Leu Tyr Ser Val Ala Thr Thr Leu Val Asn
     450                 455                 460                
 Cys Thr Asn Ser Tyr Asp Val Lys Glu Val Ile Pro Glu Leu Val Gln
 465                 470                 475                 480
 Leu Ala Lys Phe Ser Lys Gln His Val Pro Glu Glu His Pro Lys Asp
                 485                 490                 495    
 Lys Lys Asp Phe Ile Asp Met Arg Val Lys Arg Leu Leu Lys Ala Gly
             500                 505                 510        
 Val Ile Ser Ala Leu Ala Cys Met Val Lys Ala Asp Ser Ala Ile Leu
         515                 520                 525            
 Thr Asp Gln Thr Lys Glu Leu Leu Ala Arg Val Phe Leu Ala Leu Cys
     530                 535                 540                
 Asp Asn Pro Lys Asp Arg Gly Thr Ile Val Ala Gln Gly Gly Gly Lys
 545                 550                 555                 560
 Ala Leu Ile Pro Leu Ala Leu Glu Gly Thr Asp Val Gly Lys Val Lys
                 565                 570                 575    
 Ala Ala His Ala Leu Ala Lys Ile Ala Ala Val Ser Asn Pro Asp Ile
             580                 585                 590        
 Ala Phe Pro Gly Glu Arg Val Tyr Glu Val Val Arg Pro Leu Val Arg
         595                 600                 605            
 Leu Leu Asp Thr Gln Arg Asp Gly Leu Gln Asn Tyr Glu Ala Leu Leu
     610                 615                 620                
 Gly Leu Thr Asn Leu Ser Gly Arg Ser Asp Lys Leu Arg Gln Lys Ile
 625                 630                 635                 640
 Phe Lys Glu Arg Ala Leu Pro Asp Ile Glu Asn Tyr Met Phe Glu Asn
                 645                 650                 655    
 His Asp Gln Leu Arg Gln Ala Ala Thr Glu Cys Met Cys Asn Met Val
             660                 665                 670        
 Leu His Lys Glu Val Gln Glu Arg Phe Leu Ala Asp Gly Asn Asp Arg
         675                 680                 685            
 Leu Lys Leu Val Val Leu Leu Cys Gly Glu Asp Asp Asp Lys Val Gln
     690                 695                 700                
 Asn Ala Ala Ala Gly Ala Leu Ala Met Leu Thr Ala Ala His Lys Lys
 705                 710                 715                 720
 Leu Cys Leu Lys Met Thr Gln Val Thr Thr Gln Trp Leu Glu Ile Leu
                 725                 730                 735    
 Gln Arg Leu Cys Leu His Asp Gln Leu Ser Val Gln His Arg Gly Leu
             740                 745                 750        
 Val Ile Ala Tyr Asn Leu Leu Ala Ala Asp Ala Glu Leu Ala Lys Lys
         755                 760                 765            
 Leu Val Glu Ser Glu Leu Leu Glu Ile Leu Thr Val Val Gly Lys Gln
     770                 775                 780                
 Glu Pro Asp Glu Lys Lys Ala Glu Val Val Gln Thr Ala Arg Glu Cys
 785                 790                 795                 800
 Leu Ile Lys Cys Met Asp Tyr Gly Phe Ile Lys Pro Val Ser
                 805                 810                



      <210> 1271
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 1271
 Met Ala Ala Leu Gly Thr Val Leu Phe Thr Gly Val Arg Arg Leu His
   1               5                  10                  15    
 Cys Ser Ala Ala Ala Trp Ala Gly Gly Gln Trp Arg Leu Gln Gln Gly
              20                  25                  30        
 Leu Ala Ala Asn Pro Ser Gly Tyr Gly Pro Leu Thr Glu Leu Pro Asp
          35                  40                  45            
 Trp Ser Tyr Ala Asp Gly Arg Pro Ala Pro Pro Met Lys Gly Gln Leu
      50                  55                  60                
 Arg Arg Lys Ala Glu Arg Glu Thr Phe Ala Arg Arg Val Val Leu Leu
  65                  70                  75                  80
 Ser Gln Glu Met Asp Ala Gly Leu Gln Ala Trp Gln Leu Arg Gln Gln
                  85                  90                  95    
 Lys Leu Gln Glu Glu Gln Arg Lys Gln Glu Asn Ala Leu Lys Pro Lys
             100                 105                 110        
 Gly Ala Ser Leu Lys Ser Pro Leu Pro Ser Gln
         115                 120            



      <210> 1272
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 1272
 Met Lys Thr Lys Thr Gly Leu Ala Ala Asp Ile Gly Leu Leu Cys Ser
   1               5                  10                  15    
 Leu Cys Phe Leu Phe Pro Pro Phe Pro Pro Pro Ser Pro His Pro Ile
              20                  25                  30        
 Leu Phe Phe Phe Phe Phe Ala Phe Leu Phe Phe Phe Phe Ser Phe Tyr
          35                  40                  45            
 Leu Leu Tyr Leu Val Cys Leu Phe Leu Val Ala Ser Gln Val Arg Lys
      50                  55                  60                
 Leu Phe Arg Lys Val Ser Leu Cys Ile Cys Thr Arg
  65                  70                  75    



      <210> 1273
      <211> 435
      <212> PRT
      <213> Homo sapiens


      <400> 1273
 Met Gly Gln Glu Leu Cys Ala Lys Thr Val Gln Pro Gly Cys Ser Cys
   1               5                  10                  15    
 Tyr His Cys Ser Glu Gly Gly Glu Ala His Ser Cys Arg Arg Ser Gln
              20                  25                  30        
 Pro Glu Thr Thr Glu Ala Ala Phe Lys Leu Thr Asp Leu Lys Glu Ala
          35                  40                  45            
 Ser Cys Ser Met Thr Ser Phe His Pro Arg Gly Leu Gln Ala Ala Arg
      50                  55                  60                
 Ala Gln Lys Phe Lys Ser Lys Arg Pro Arg Ser Asn Ser Asp Cys Phe
  65                  70                  75                  80
 Gln Glu Glu Asp Leu Arg Gln Gly Phe Gln Trp Arg Lys Ser Leu Pro
                  85                  90                  95    
 Phe Gly Ala Ala Ser Ser Tyr Leu Asn Leu Glu Lys Leu Gly Glu Gly
             100                 105                 110        
 Ser Tyr Ala Thr Val Tyr Lys Gly Ile Ser Arg Ile Asn Gly Gln Leu
         115                 120                 125            
 Val Ala Leu Lys Val Ile Ser Met Asn Ala Glu Glu Gly Val Pro Phe
     130                 135                 140                
 Thr Ala Ile Arg Glu Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn
 145                 150                 155                 160
 Ile Val Leu Leu His Asp Ile Ile His Thr Lys Glu Thr Leu Thr Phe
                 165                 170                 175    
 Val Phe Glu Tyr Met His Thr Asp Leu Ala Gln Tyr Met Ser Gln His
             180                 185                 190        
 Pro Gly Gly Leu His Pro His Asn Val Arg Leu Phe Met Phe Gln Leu
         195                 200                 205            
 Leu Arg Gly Leu Ala Tyr Ile His His Gln His Val Leu His Arg Asp
     210                 215                 220                
 Leu Lys Pro Gln Asn Leu Leu Ile Ser His Leu Gly Glu Leu Lys Leu
 225                 230                 235                 240
 Ala Asp Phe Gly Leu Ala Arg Ala Lys Ser Ile Pro Ser Gln Thr Tyr
                 245                 250                 255    
 Ser Ser Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Ala Leu Leu
             260                 265                 270        
 Gly Ala Thr Glu Tyr Ser Ser Glu Leu Asp Ile Trp Gly Ala Gly Cys
         275                 280                 285            
 Ile Phe Ile Glu Met Phe Gln Gly Gln Pro Leu Phe Pro Gly Val Ser
     290                 295                 300                
 Asn Ile Leu Glu Gln Leu Glu Lys Ile Trp Glu Val Leu Gly Val Pro
 305                 310                 315                 320
 Thr Glu Asp Thr Trp Pro Gly Val Ser Lys Leu Pro Asn Tyr Asn Pro
                 325                 330                 335    
 Glu Trp Phe Pro Leu Pro Thr Pro Arg Ser Leu His Val Val Trp Asn
             340                 345                 350        
 Arg Leu Gly Arg Val Pro Glu Ala Glu Asp Leu Ala Ser Gln Met Leu
         355                 360                 365            
 Lys Gly Phe Pro Arg Asp Arg Val Ser Ala Gln Glu Ala Leu Val His
     370                 375                 380                
 Asp Tyr Phe Ser Ala Leu Pro Ser Gln Leu Tyr Gln Leu Pro Asp Glu
 385                 390                 395                 400
 Glu Ser Leu Phe Thr Val Ser Gly Val Arg Leu Lys Pro Glu Met Cys
                 405                 410                 415    
 Asp Leu Leu Ala Ser Tyr Gln Lys Gly His His Pro Ala Gln Phe Ser
             420                 425                 430        
 Lys Cys Trp
         435



      <210> 1274
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 1274
 Met Arg Leu Gln Arg Pro Arg Gln Ala Pro Ala Gly Gly Arg Arg Ala
   1               5                  10                  15    
 Pro Arg Gly Gly Arg Gly Ser Pro Tyr Arg Pro Asp Pro Gly Arg Gly
              20                  25                  30        
 Ala Arg Arg Leu Arg Arg Phe Gln Lys Gly Gly Glu Gly Ala Pro Arg
          35                  40                  45            
 Ala Asp Pro Pro Trp Ala Pro Leu Gly Thr Met Ala Leu Leu Ala Leu
      50                  55                  60                
 Leu Leu Val Val Ala Leu Pro Arg Val Trp Thr Asp Ala Asn Leu Thr
  65                  70                  75                  80
 Ala Arg Gln Arg Asp Pro Glu Asp Ser Gln Arg Thr Asp Glu Gly Asp
                  85                  90                  95    
 Asn Arg Val Trp Cys His Val Cys Glu Arg Glu Asn Thr Phe Glu Cys
             100                 105                 110        
 Gln Asn Pro Arg Arg Cys Lys Trp Thr Glu Pro Tyr Cys Val Ile Ala
         115                 120                 125            
 Ala Val Met Leu Arg Trp Leu Cys Ser Asp Gly Glu Thr Gln Ala Arg
     130                 135                 140                
 Gly Glu Ala Val Ser Pro Gly Arg Ala His Ala Leu Leu Leu Pro Gln
 145                 150                 155                 160
 Val Leu
        



      <210> 1275
      <211> 840
      <212> PRT
      <213> Homo sapiens


      <400> 1275
 Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu
   1               5                  10                  15    
 Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln
              20                  25                  30        
 Gly Glu Asp Ala Gly Gly Val Pro Leu Thr Leu Cys Ser Val Phe Thr
          35                  40                  45            
 Pro Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp
      50                  55                  60                
 Gly Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro
  65                  70                  75                  80
 Asp Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu
                  85                  90                  95    
 Glu Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr
             100                 105                 110        
 His Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr
         115                 120                 125            
 Asp His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp
     130                 135                 140                
 Val Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser
 145                 150                 155                 160
 Arg Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys
                 165                 170                 175    
 Asp Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp
             180                 185                 190        
 Lys Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr
         195                 200                 205            
 Ser Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg
     210                 215                 220                
 Thr Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe
 225                 230                 235                 240
 Leu Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu
                 245                 250                 255    
 Val Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val
             260                 265                 270        
 Ala Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val
         275                 280                 285            
 Thr Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg
     290                 295                 300                
 Gly Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly
 305                 310                 315                 320
 Arg Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met
                 325                 330                 335    
 Cys Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu
             340                 345                 350        
 Pro Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu
         355                 360                 365            
 Gly Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu
     370                 375                 380                
 Ser Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg
 385                 390                 395                 400
 Val Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys
                 405                 410                 415    
 Gly Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val
             420                 425                 430        
 Pro Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys
         435                 440                 445            
 Asp Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His
     450                 455                 460                
 Asn Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys
 465                 470                 475                 480
 Val Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met
                 485                 490                 495    
 Gly Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys
             500                 505                 510        
 Pro Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser
         515                 520                 525            
 Gly Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln
     530                 535                 540                
 Gln Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln
 545                 550                 555                 560
 Val Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser
                 565                 570                 575    
 Glu Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys
             580                 585                 590        
 Leu Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val
         595                 600                 605            
 Pro Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg
     610                 615                 620                
 Gly Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly
 625                 630                 635                 640
 Leu Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Gln Ser
                 645                 650                 655    
 Arg Arg Cys Arg Lys Asn Ala Phe Gln Glu Leu Gln Arg Cys Leu Thr
             660                 665                 670        
 Ala Cys His Ser His Gly Val Cys Asn Ser Asn His Asn Cys His Cys
         675                 680                 685            
 Ala Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys Pro Gly Phe Gly Gly
     690                 695                 700                
 Ser Met Asp Ser Gly Pro Val Gln Ala Glu Asn His Asp Thr Phe Leu
 705                 710                 715                 720
 Leu Ala Met Leu Leu Ser Val Leu Leu Pro Leu Leu Pro Gly Ala Gly
                 725                 730                 735    
 Leu Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala His Leu Gln Arg Cys
             740                 745                 750        
 Ser Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser Gly Pro Lys Asp Gly
         755                 760                 765            
 Pro His Arg Asp His Pro Leu Gly Gly Val His Pro Met Glu Leu Gly
     770                 775                 780                
 Pro Thr Ala Thr Gly Gln Pro Trp Pro Leu Ala Pro Gly Ser Pro Ala
 785                 790                 795                 800
 Asp His Ile His Asn Ile Tyr Pro Pro Pro Phe Leu Pro Asp Pro Glu
                 805                 810                 815    
 Asn Ser His Glu Pro Ser Ser His Pro Glu Lys Pro Leu Pro Ala Val
             820                 825                 830        
 Ser Pro Asp Pro Gln Gly Gly Ser
         835                 840



      <210> 1276
      <211> 525
      <212> PRT
      <213> Homo sapiens


      <400> 1276
 Met Ala Ala Ala Pro Pro Leu Arg Asp Arg Leu Ser Phe Leu His Arg
   1               5                  10                  15    
 Leu Pro Ile Leu Leu Lys Gly Thr Ser Asp Asp Asp Val Pro Cys Pro
              20                  25                  30        
 Gly Tyr Leu Phe Glu Glu Ile Ala Lys Ile Ser His Glu Ser Pro Gly
          35                  40                  45            
 Ser Ser Gln Cys Leu Leu Glu Tyr Leu Leu Ser Arg Leu His Ser Ser
      50                  55                  60                
 Ser Gly His Gly Lys Leu Lys Val Leu Lys Ile Leu Leu Tyr Leu Cys
  65                  70                  75                  80
 Ser His Gly Ser Ser Phe Phe Leu Leu Ile Leu Lys Arg Asn Ser Ala
                  85                  90                  95    
 Phe Ile Gln Glu Ala Ala Ala Phe Ala Gly Pro Pro Asp Pro Leu His
             100                 105                 110        
 Gly Asn Ser Leu Tyr Gln Lys Val Arg Ala Ala Ala Gln Asp Leu Gly
         115                 120                 125            
 Ser Thr Leu Phe Ser Asp Thr Val Leu Pro Leu Ala Pro Ser Gln Pro
     130                 135                 140                
 Leu Gly Thr Pro Pro Ala Thr Gly Met Gly Ser Gln Ala Arg Pro His
 145                 150                 155                 160
 Ser Thr Leu Gln Gly Phe Gly Tyr Ser Lys Glu His Gly Arg Thr Ala
                 165                 170                 175    
 Val Arg His Gln Pro Gly Gln Ala Gly Gly Gly Trp Asp Glu Leu Asp
             180                 185                 190        
 Ser Gly Pro Ser Ser Gln Asn Ser Ser Gln Asn Ser Asp Leu Ser Arg
         195                 200                 205            
 Val Ser Asp Ser Gly Ser His Ser Gly Ser Asp Ser His Ser Gly Ala
     210                 215                 220                
 Ser Arg Glu Pro Gly Asp Leu Ala Glu Arg Val Glu Val Val Ala Leu
 225                 230                 235                 240
 Ser Asp Cys Gln Gln Glu Leu Ser Leu Val Arg Thr Val Thr Arg Gly
                 245                 250                 255    
 Pro Arg Ala Phe Leu Ser Arg Glu Glu Ala Gln His Phe Ile Lys Ala
             260                 265                 270        
 Cys Gly Leu Leu Asn Cys Glu Ala Val Leu Gln Leu Leu Thr Cys His
         275                 280                 285            
 Leu Arg Gly Thr Ser Glu Cys Thr Gln Leu Arg Ala Leu Cys Ala Ile
     290                 295                 300                
 Ala Ser Leu Gly Ser Ser Asp Leu Leu Pro Gln Glu His Ile Leu Leu
 305                 310                 315                 320
 Arg Thr Arg Pro Trp Leu Gln Glu Leu Ser Met Gly Ser Pro Gly Pro
                 325                 330                 335    
 Val Thr Asn Lys Ala Thr Lys Ile Leu Arg His Phe Glu Ala Ser Cys
             340                 345                 350        
 Gly Gln Leu Ser Pro Ala Arg Gly Thr Ser Ala Glu Pro Gly Pro Thr
         355                 360                 365            
 Ala Ala Leu Pro Gly Pro Ser Asp Leu Leu Thr Asp Ala Val Pro Leu
     370                 375                 380                
 Pro Gly Ser Gln Val Phe Leu Gln Pro Leu Ser Ser Thr Pro Val Ser
 385                 390                 395                 400
 Ser Arg Ser Pro Ala Pro Ser Ser Gly Met Pro Ser Ser Pro Val Pro
                 405                 410                 415    
 Thr Pro Pro Pro Asp Ala Ser Pro Ile Pro Ala Pro Gly Asp Pro Ser
             420                 425                 430        
 Glu Ala Glu Ala Arg Leu Ala Glu Ser Arg Arg Trp Arg Pro Glu Arg
         435                 440                 445            
 Ile Pro Gly Gly Thr Asp Ser Pro Lys Arg Gly Pro Ser Ser Cys Ala
     450                 455                 460                
 Trp Ser Arg Asp Ser Leu Phe Ala Gly Met Glu Leu Val Ala Cys Pro
 465                 470                 475                 480
 Arg Leu Val Gly Ala Gly Ala Ala Ala Gly Glu Ser Cys Pro Asp Ala
                 485                 490                 495    
 Pro Arg Ala Pro Gln Thr Ser Ser Gln Arg Thr Ala Ala Lys Glu Pro
             500                 505                 510        
 Pro Gly Ser Glu Pro Ser Ala Phe Ala Phe Leu Asn Ala
         515                 520                 525



      <210> 1277
      <211> 525
      <212> PRT
      <213> Homo sapiens


      <400> 1277
 Met Glu Gly Pro Ala Glu Trp Gly Pro Glu Ala Ala Leu Gly Pro Glu
   1               5                  10                  15    
 Ala Val Leu Arg Phe Leu Ala Glu Arg Gly Gly Arg Ala Leu His Ala
              20                  25                  30        
 Glu Leu Val Gln His Phe Arg Gly Ala Leu Gly Gly Glu Pro Glu Gln
          35                  40                  45            
 Arg Ala Arg Ala Arg Ala His Phe Lys Glu Leu Val Asn Ala Val Ala
      50                  55                  60                
 Thr Val Arg Val Asp Pro Ala Asp Gly Ala Lys Tyr Val His Leu Lys
  65                  70                  75                  80
 Lys Arg Phe Cys Glu Gly Pro Ser Glu Pro Ser Gly Asp Pro Pro Arg
                  85                  90                  95    
 Ile Gln Val Thr Ala Glu Pro Glu Ala Pro Asp Gly Pro Ala Gly Pro
             100                 105                 110        
 Glu Ala Arg Asp Arg Leu Pro Asp Ala Ala Ala Pro Glu Ser Leu Pro
         115                 120                 125            
 Gly Gln Gly Arg Glu Leu Gly Glu Gly Glu Pro Pro Ala Pro Ala His
     130                 135                 140                
 Trp Pro Pro Leu Ser Ala Gly Ala Arg Arg Lys Asn Ser Arg Arg Asp
 145                 150                 155                 160
 Val Gln Pro Leu Pro Arg Thr Pro Ala Pro Gly Pro Ser Glu Asp Leu
                 165                 170                 175    
 Glu Leu Pro Pro His Gly Cys Glu Glu Ala Asp Arg Gly Ser Ser Leu
             180                 185                 190        
 Val Gly Ala Thr Ala Gln Arg Pro Ala Arg Gln Asn Leu Arg Asp Leu
         195                 200                 205            
 Val Met Gly Ser Ser Pro Gln Leu Lys Arg Ser Val Cys Pro Gly Gly
     210                 215                 220                
 Ser Ser Pro Gly Ser Ser Ser Gly Gly Gly Arg Gly Arg Gly Gly Gly
 225                 230                 235                 240
 Asp Ser Asp Ser Ala Ser Val Ala Ser Ser Ser Ala Glu Glu Glu Ser
                 245                 250                 255    
 Ser Gly Gly Gly Ser Val Thr Leu Asp Pro Leu Glu His Ala Trp Met
             260                 265                 270        
 Leu Ser Ala Ser Asp Gly Lys Trp Asp Ser Leu Glu Gly Leu Leu Thr
         275                 280                 285            
 Cys Glu Pro Gly Leu Leu Val Lys Arg Asp Phe Ile Thr Gly Phe Thr
     290                 295                 300                
 Cys Leu His Trp Ala Ala Lys His Gly Arg Gln Glu Leu Leu Ala Met
 305                 310                 315                 320
 Leu Val Asn Phe Ala Asn Lys His Gln Leu Pro Val Asn Ile Asp Ala
                 325                 330                 335    
 Arg Thr Ser Gly Gly Tyr Thr Ala Leu His Leu Ala Ala Met His Gly
             340                 345                 350        
 His Val Glu Val Val Lys Leu Leu Val Gly Ala Tyr Asp Ala Asp Val
         355                 360                 365            
 Asp Ile Arg Asp Tyr Ser Gly Lys Lys Ala Ser Gln Tyr Leu Ser Arg
     370                 375                 380                
 Ser Ile Ala Glu Glu Ile Lys Asn Leu Val Gly Ala Leu Asp Glu Gly
 385                 390                 395                 400
 Asp Gly Glu Ser Ala Ala Gly Ser Gly Gly Gly Arg Trp Arg Leu Ser
                 405                 410                 415    
 Lys Val Leu Pro Ser His Leu Ile Thr Tyr Lys Leu Ser His Ala Leu
             420                 425                 430        
 Glu Asp Gly Gly Asp His His His His His His Ser Ala Glu Gly Trp
         435                 440                 445            
 Val Gly Gly Lys Ala Lys Asp Pro Gly Arg Lys Ala Ser Gly Ser Ser
     450                 455                 460                
 Ser Gly Arg Ile Lys Pro Arg Leu Asn Lys Ile Arg Phe Arg Thr Gln
 465                 470                 475                 480
 Ile Val His Thr Thr Pro Ser Phe Arg Asp Pro Glu Gln Pro Leu Glu
                 485                 490                 495    
 Gly Arg Gly Glu Glu Gly Val Gly Glu Glu Arg Pro Val Lys Gly His
             500                 505                 510        
 Ser Pro Phe Thr Leu Arg Pro Lys Ser Asn Val Phe Gly
         515                 520                 525



      <210> 1278
      <211> 624
      <212> PRT
      <213> Homo sapiens


      <400> 1278
 Met Gly Pro Pro Ser Ser Ser Gly Phe Tyr Val Ser Arg Ala Val Ala
   1               5                  10                  15    
 Leu Leu Leu Ala Gly Leu Val Ala Ala Leu Leu Leu Ala Leu Ala Val
              20                  25                  30        
 Leu Ala Ala Leu Tyr Gly His Cys Glu Arg Val Pro Pro Ser Glu Leu
          35                  40                  45            
 Pro Gly Leu Arg Asp Ser Glu Ala Glu Ser Ser Pro Pro Leu Arg Gln
      50                  55                  60                
 Lys Pro Thr Pro Thr Pro Lys Pro Ser Ser Ala Arg Glu Leu Ala Val
  65                  70                  75                  80
 Thr Thr Thr Pro Ser Asn Trp Arg Pro Pro Gly Pro Trp Asp Gln Leu
                  85                  90                  95    
 Arg Leu Pro Pro Trp Leu Val Pro Leu His Tyr Asp Leu Glu Leu Trp
             100                 105                 110        
 Pro Gln Leu Arg Pro Asp Glu Leu Pro Ala Gly Ser Leu Pro Phe Thr
         115                 120                 125            
 Gly Arg Val Asn Ile Thr Val Arg Cys Thr Val Ala Thr Ser Arg Leu
     130                 135                 140                
 Leu Leu His Ser Leu Phe Gln Asp Cys Glu Arg Ala Glu Val Arg Gly
 145                 150                 155                 160
 Pro Leu Ser Pro Gly Thr Gly Asn Ala Thr Val Gly Arg Val Pro Val
                 165                 170                 175    
 Asp Asp Val Trp Phe Ala Leu Asp Thr Glu Tyr Met Val Leu Glu Leu
             180                 185                 190        
 Ser Glu Pro Leu Lys Pro Gly Ser Ser Tyr Glu Leu Gln Leu Ser Phe
         195                 200                 205            
 Ser Gly Leu Val Lys Glu Asp Leu Arg Glu Gly Leu Phe Leu Asn Val
     210                 215                 220                
 Tyr Thr Asp Gln Gly Glu Arg Arg Ala Leu Leu Ala Ser Gln Leu Glu
 225                 230                 235                 240
 Pro Thr Phe Ala Arg Tyr Val Phe Pro Cys Phe Asp Glu Pro Ala Leu
                 245                 250                 255    
 Lys Ala Thr Phe Asn Ile Thr Met Ile His His Pro Ser Tyr Val Ala
             260                 265                 270        
 Leu Ser Asn Met Pro Lys Leu Gly Gln Ser Glu Lys Glu Asp Val Asn
         275                 280                 285            
 Gly Ser Lys Trp Thr Val Thr Thr Phe Ser Thr Thr Pro His Met Pro
     290                 295                 300                
 Thr Tyr Leu Val Ala Phe Val Ile Cys Asp Tyr Asp His Val Asn Arg
 305                 310                 315                 320
 Thr Glu Arg Gly Lys Glu Ile Arg Ile Trp Ala Arg Lys Asp Ala Ile
                 325                 330                 335    
 Ala Asn Gly Ser Ala Asp Phe Ala Leu Asn Ile Thr Gly Pro Ile Phe
             340                 345                 350        
 Ser Phe Leu Glu Asp Leu Phe Asn Ile Ser Tyr Ser Leu Pro Lys Thr
         355                 360                 365            
 Asp Ile Ile Ala Leu Pro Ser Phe Asp Asn His Ala Met Glu Asn Trp
     370                 375                 380                
 Gly Leu Met Ile Phe Asp Glu Ser Gly Leu Ser Ser Glu Pro Lys Asp
 385                 390                 395                 400
 Gln Leu Thr Glu Lys Lys Thr Leu Ile Ser Tyr Val Val Ser His Glu
                 405                 410                 415    
 Ile Gly His Gln Trp Phe Gly Asn Leu Val Thr Met Asn Arg Trp Asn
             420                 425                 430        
 Asn Ile Trp Leu Asn Glu Gly Leu His Leu Ile Leu Glu Phe Glu Val
         435                 440                 445            
 Ile Asn Tyr Phe Asn Pro Lys Leu Pro Arg Asn Glu Ile Phe Phe Ser
     450                 455                 460                
 Asn Ile Leu His Asn Ile Leu Arg Glu Asp His Ala Leu Val Thr Arg
 465                 470                 475                 480
 Ala Val Ala Met Lys Val Glu Asn Phe Lys Thr Ser Glu Ile Gln Glu
                 485                 490                 495    
 Leu Phe Asp Ile Phe Thr Tyr Ser Lys Gly Ala Ser Met Ala Arg Met
             500                 505                 510        
 Leu Ser Cys Phe Leu Asn Glu His Leu Phe Val Ser Ala Leu Lys Ser
         515                 520                 525            
 Tyr Leu Lys Thr Phe Ser Tyr Ser Asn Ala Glu Gln Asp Asp Leu Trp
     530                 535                 540                
 Arg His Phe Gln Met Ala Ile Asp Asp Gln Ser Thr Val Ile Leu Pro
 545                 550                 555                 560
 Ala Thr Ile Lys Asn Ile Met Asp Ser Trp Thr His Gln Ser Gly Phe
                 565                 570                 575    
 Pro Val Ile Thr Leu Asn Val Ser Thr Gly Val Met Lys Gln Glu Pro
             580                 585                 590        
 Phe Tyr Leu Glu Asn Ile Lys Asn Arg Thr Leu Leu Thr Ser Asn Asp
         595                 600                 605            
 Thr Trp Ile Val Pro Ile Leu Gly Ser Lys Met Glu Leu His Lys Leu
     610                 615                 620                





      <210> 1279
      <211> 208
      <212> PRT
      <213> Homo sapiens


      <400> 1279
 Met Trp Leu Phe Ile Leu Leu Ser Leu Ala Leu Ile Ser Asp Ala Met
   1               5                  10                  15    
 Val Met Asp Glu Lys Val Lys Arg Ser Phe Val Leu Asp Thr Ala Ser
              20                  25                  30        
 Ala Ile Cys Asn Tyr Asn Ala His Tyr Lys Asn His Pro Lys Tyr Trp
          35                  40                  45            
 Cys Arg Gly Tyr Phe Arg Asp Tyr Cys Asn Ile Ile Ala Phe Ser Pro
      50                  55                  60                
 Asn Ser Thr Asn His Val Ala Leu Arg Asp Thr Gly Asn Gln Leu Ile
  65                  70                  75                  80
 Val Thr Met Ser Cys Leu Thr Lys Glu Asp Thr Gly Trp Tyr Trp Cys
                  85                  90                  95    
 Gly Ile Gln Arg Asp Phe Ala Arg Asp Asp Met Asp Phe Thr Glu Leu
             100                 105                 110        
 Ile Val Thr Asp Asp Lys Gly Thr Leu Ala Asn Asp Phe Trp Ser Gly
         115                 120                 125            
 Lys Asp Leu Ser Gly Asn Lys Thr Arg Ser Cys Lys Ala Pro Lys Val
     130                 135                 140                
 Val Arg Lys Ala Asp Arg Ser Arg Thr Ser Ile Leu Ile Ile Cys Ile
 145                 150                 155                 160
 Leu Ile Thr Gly Leu Gly Ile Ile Ser Val Ile Ser His Leu Thr Lys
                 165                 170                 175    
 Arg Arg Arg Ser Gln Arg Asn Arg Arg Val Gly Asn Thr Leu Lys Pro
             180                 185                 190        
 Phe Ser Arg Val Leu Thr Pro Lys Glu Met Ala Pro Thr Glu Gln Met
         195                 200                 205            





      <210> 1280
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 1280
 Met Trp Ser Leu Trp Ile Trp Val Asp Gln His Gln Ala Arg Leu Ile
   1               5                  10                  15    
 Pro Ser Pro Gln Val Leu Leu Leu Leu Leu Arg Glu Thr Pro Ser Thr
              20                  25                  30        
 Ala Ala Ala Val Ala Gly Trp Leu Val Val Ala Ser Met Ala Leu Leu
          35                  40                  45            
 Gln Leu His Ala Val Gly Gly Val Ala Leu Thr Ser Ser His Pro Ser
      50                  55                  60                
 Met Trp Ala Thr Gly Glu Glu Leu Arg Lys Pro Pro Trp Gln Gly Ser
  65                  70                  75                  80
 Ala Gly Ser Ala Ser Gly Val Glu Glu Leu Thr Gly Lys His Ser Cys
                  85                  90                  95    
 Pro Gly Pro Glu Glu Pro Ala Thr Val Gln Lys Ala Pro Ala
             100                 105                 110



      <210> 1281
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 1281
 Met Leu Ala Pro Cys Ser Gly Trp Glu Leu Gly Cys Phe Arg Leu Cys
   1               5                  10                  15    
 Leu Arg Gln Val Arg Leu Trp Ala Gly Ala Gly Arg Trp Ala Cys Trp
              20                  25                  30        
 Ala Cys Gln Ala Arg Pro Tyr Ser Ser Gly Gly Ser Glu Arg Trp Pro
          35                  40                  45            
 Gly Ser Glu Thr Glu Val Pro Pro Pro Gly Pro Ala Arg Arg Thr Leu
      50                  55                  60                
 Lys Glu Trp Thr Leu Gln Val
  65                  70    



      <210> 1282
      <211> 144
      <212> PRT
      <213> Homo sapiens


      <400> 1282
 Met Leu Ala Pro Cys Ser Gly Trp Glu Leu Gly Cys Phe Arg Leu Cys
   1               5                  10                  15    
 Leu Arg Gln Val Arg Leu Trp Ala Gly Ala Gly Arg Trp Ala Cys Trp
              20                  25                  30        
 Ala Cys Gln Ala Arg Pro Tyr Ser Ser Gly Gly Ser Glu Arg Trp Pro
          35                  40                  45            
 Gly Ser Glu Thr Glu Val Pro Pro Pro Gly Pro Ala Arg Arg Thr Leu
      50                  55                  60                
 Lys Glu Trp Thr Leu Gln Val Ser Pro Phe Gly Arg Leu Arg Ala Arg
  65                  70                  75                  80
 Leu Pro Cys His Leu Ala Val Arg Pro Leu Asp Pro Leu Thr Tyr Pro
                  85                  90                  95    
 Asp Gly Asp Arg Val Leu Val Ala Val Cys Gly Val Glu Gly Gly Val
             100                 105                 110        
 Arg Gly Leu Asp Gly Leu Gln Val Lys Tyr Asp Glu Asp Leu Glu Glu
         115                 120                 125            
 Met Ala Ile Val Ser Asp Thr Ile His Pro Gln Ala Ser Val Glu Val
     130                 135                 140                





      <210> 1283
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 1283
 Met Leu Ala Pro Cys Ser Gly Trp Glu Leu Gly Cys Ile Arg Leu Cys
   1               5                  10                  15    
 Leu Arg Gln Val Arg Leu Trp Ala Gly Ala Gly Arg Trp Ala Cys Trp
              20                  25                  30        
 Ala Cys Gln Ala Arg Pro Tyr Ser Ser Gly Gly Ser Glu Arg Trp Pro
          35                  40                  45            
 Gly Ser Glu Thr Glu Val Pro Pro Pro Gly Pro Ala Arg Arg Thr Leu
      50                  55                  60                
 Lys Glu Trp Thr Leu Gln Val Ser Pro Phe Gly Arg Leu Arg Ala Arg
  65                  70                  75                  80
 Leu Pro Cys His Leu Ala Val Arg Pro Leu Asp Pro Leu Thr Tyr Pro
                  85                  90                  95    
 Asp Gly Asp Arg Val Leu Val Ala Val Cys Gly Val Glu Gly Gly Val
             100                 105                 110        
 Arg Gly Leu Asp Gly Leu Gln Val Lys Tyr Asp Glu Asp Leu Glu Glu
         115                 120                 125            
 Met Ala Ile Val Ser Asp Thr Ile His Pro Gln Ala Ser Val Glu Val
     130                 135                 140                
 Asn Ala Pro Leu Lys Phe Gly Lys
 145                 150        



      <210> 1284
      <211> 780
      <212> PRT
      <213> Homo sapiens


      <400> 1284
 Met Thr Ala Ala Ala Ala Ser Asn Trp Gly Leu Ile Thr Asn Ile Val
   1               5                  10                  15    
 Asn Ser Ile Val Gly Val Ser Val Leu Thr Met Pro Phe Cys Phe Lys
              20                  25                  30        
 Gln Cys Gly Ile Val Leu Gly Ala Leu Leu Leu Val Phe Cys Ser Trp
          35                  40                  45            
 Met Thr His Gln Ser Cys Met Phe Leu Val Lys Ser Ala Ser Leu Ser
      50                  55                  60                
 Lys Arg Arg Thr Tyr Ala Gly Leu Ala Phe His Ala Tyr Gly Lys Ala
  65                  70                  75                  80
 Gly Lys Met Leu Val Glu Thr Ser Met Ile Gly Leu Met Leu Gly Thr
                  85                  90                  95    
 Cys Ile Ala Phe Tyr Val Val Ile Gly Asp Leu Gly Ser Asn Phe Phe
             100                 105                 110        
 Ala Arg Leu Phe Gly Phe Gln Val Gly Gly Thr Phe Arg Met Phe Leu
         115                 120                 125            
 Leu Phe Ala Val Ser Leu Cys Ile Val Leu Pro Leu Ser Leu Gln Arg
     130                 135                 140                
 Asn Met Met Ala Ser Ile Gln Ser Phe Ser Ala Met Ala Leu Leu Phe
 145                 150                 155                 160
 Tyr Thr Val Phe Met Phe Val Ile Val Leu Ser Ser Leu Lys His Gly
                 165                 170                 175    
 Leu Phe Ser Gly Gln Trp Leu Arg Arg Val Ser Tyr Val Arg Trp Glu
             180                 185                 190        
 Gly Val Phe Arg Cys Ile Pro Ile Phe Gly Met Ser Phe Ala Cys Gln
         195                 200                 205            
 Ser Gln Val Leu Pro Thr Tyr Asp Ser Leu Asp Glu Pro Ser Val Lys
     210                 215                 220                
 Thr Met Ser Ser Ile Phe Ala Ser Ser Leu Asn Val Val Thr Thr Phe
 225                 230                 235                 240
 Tyr Val Met Val Gly Phe Phe Gly Tyr Val Ser Phe Thr Glu Ala Thr
                 245                 250                 255    
 Ala Gly Asn Val Leu Met His Phe Pro Ser Asn Leu Val Thr Glu Met
             260                 265                 270        
 Leu Arg Val Gly Phe Met Met Ser Val Ala Val Gly Phe Pro Met Met
         275                 280                 285            
 Ile Leu Pro Cys Arg Gln Ala Leu Ser Thr Leu Leu Cys Glu Gln Gln
     290                 295                 300                
 Gln Lys Asp Gly Thr Phe Ala Ala Gly Gly Tyr Met Pro Pro Leu Arg
 305                 310                 315                 320
 Phe Lys Ala Leu Thr Leu Ser Val Val Phe Gly Thr Met Val Gly Gly
                 325                 330                 335    
 Ile Leu Ile Pro Asn Val Glu Thr Ile Leu Gly Leu Thr Gly Ala Thr
             340                 345                 350        
 Met Gly Ser Leu Ile Cys Phe Ile Cys Pro Ala Leu Ile Tyr Lys Lys
         355                 360                 365            
 Ile His Lys Asn Ala Leu Ser Ser Gln Val Val Leu Trp Val Gly Leu
     370                 375                 380                
 Gly Val Leu Val Val Ser Thr Val Thr Thr Leu Ser Val Ser Glu Glu
 385                 390                 395                 400
 Val Pro Glu Asp Leu Ala Glu Glu Ala Pro Gly Gly Arg Leu Gly Glu
                 405                 410                 415    
 Ala Glu Gly Leu Met Lys Val Glu Ala Ala Arg Leu Ser Ala Gln Asp
             420                 425                 430        
 Pro Val Val Ala Val Ala Glu Asp Gly Arg Glu Lys Pro Lys Leu Pro
         435                 440                 445            
 Lys Glu Arg Glu Glu Leu Glu Gln Ala Gln Ile Lys Gly Pro Val Asp
     450                 455                 460                
 Val Pro Gly Arg Glu Asp Gly Lys Glu Ala Pro Glu Glu Ala Gln Leu
 465                 470                 475                 480
 Asp Arg Pro Gly Gln Gly Ile Ala Val Pro Val Gly Glu Ala His Arg
                 485                 490                 495    
 His Glu Pro Pro Val Pro His Asp Lys Val Val Val Asp Glu Gly Gln
             500                 505                 510        
 Asp Arg Glu Val Pro Glu Glu Asn Lys Pro Pro Ser Arg His Ala Gly
         515                 520                 525            
 Gly Lys Ala Pro Gly Val Gln Gly Gln Met Ala Pro Pro Leu Pro Asp
     530                 535                 540                
 Ser Glu Arg Glu Lys Gln Glu Pro Glu Gln Gly Glu Val Gly Lys Arg
 545                 550                 555                 560
 Pro Gly Gln Ala Gln Ala Leu Glu Glu Ala Gly Asp Leu Pro Glu Asp
                 565                 570                 575    
 Pro Gln Lys Val Pro Glu Ala Asp Gly Gln Pro Ala Val Gln Pro Ala
             580                 585                 590        
 Lys Glu Asp Leu Gly Pro Gly Asp Arg Gly Leu His Pro Arg Pro Gln
         595                 600                 605            
 Ala Val Leu Ser Glu Gln Gln Asn Gly Leu Ala Val Gly Gly Gly Glu
     610                 615                 620                
 Lys Ala Lys Gly Gly Pro Pro Pro Gly Asn Ala Ala Gly Asp Thr Gly
 625                 630                 635                 640
 Gln Pro Ala Glu Asp Ser Asp His Gly Gly Lys Pro Pro Leu Pro Ala
                 645                 650                 655    
 Glu Lys Pro Ala Pro Gly Pro Gly Leu Pro Pro Glu Pro Arg Glu Gln
             660                 665                 670        
 Arg Asp Val Glu Arg Ala Gly Gly Asn Gln Ala Ala Ser Gln Leu Glu
         675                 680                 685            
 Gly Lys Ala Ser Ala Leu Gln Pro Pro Ala Ser Gly Pro Gly Ser Gly
     690                 695                 700                
 Ser Pro Leu Pro Gln Pro Trp Gly Asp Ala Gln Val Ile Leu Gly Ser
 705                 710                 715                 720
 Pro Ala Arg Pro Pro Phe Ser Phe Gln Pro Pro Ala Glu Gln Thr Pro
                 725                 730                 735    
 Arg Arg Ala Phe Cys Ser Leu Pro Ile Ser Ser Leu Leu Ser Gly Asn
             740                 745                 750        
 Leu Leu Ser Ala Leu Leu Pro Phe Lys His Leu Arg His Arg His Met
         755                 760                 765            
 Ala Cys Asp Tyr Arg Phe Ile Ser Leu Ala Pro Leu
     770                 775                 780



      <210> 1285
      <211> 225
      <212> PRT
      <213> Homo sapiens


      <400> 1285
 Met Gln Ala Arg Leu Gly Thr Gly Ser Asn His Ala Leu Gly Ala Asn
   1               5                  10                  15    
 Val Glu Leu Trp Ile Met Leu Leu Gln Val Val Arg Glu Gly Lys Phe
              20                  25                  30        
 Ser Gly Phe Leu Thr Ser Cys Ser Leu Leu Leu Pro Arg Ala Ala Gln
          35                  40                  45            
 Ile Leu Ala Ala Glu Ala Gly Leu Pro Ser Ser Arg Ser Phe Met Gly
      50                  55                  60                
 Phe Ala Ala Pro Phe Thr Asn Lys Arg Lys Ala Tyr Ser Glu Arg Arg
  65                  70                  75                  80
 Ile Met Gly Tyr Ser Met Gln Glu Met Tyr Glu Val Val Ser Asn Val
                  85                  90                  95    
 Gln Glu Tyr Arg Glu Phe Val Pro Trp Cys Lys Lys Ser Leu Val Val
             100                 105                 110        
 Ser Ser Arg Lys Gly His Leu Lys Ala Gln Leu Glu Val Gly Phe Pro
         115                 120                 125            
 Pro Val Met Glu Arg Tyr Thr Ser Ala Val Ser Met Val Lys Pro His
     130                 135                 140                
 Met Val Lys Ala Val Cys Thr Asp Gly Lys Leu Phe Asn His Leu Glu
 145                 150                 155                 160
 Thr Ile Trp Arg Phe Ser Pro Gly Ile Pro Ala Tyr Pro Arg Thr Cys
                 165                 170                 175    
 Thr Val Asp Phe Ser Ile Ser Phe Glu Phe Arg Ser Leu Leu His Ser
             180                 185                 190        
 Gln Leu Asp Thr Met Phe Leu Met Arg Leu Ser Asn Arg Met Leu Leu
         195                 200                 205            
 Pro Leu Ser Val Gly Gln Thr Pro Ser Leu Val Gln Lys Gln His Pro
     210                 215                 220                
 Pro
 225



      <210> 1286
      <211> 327
      <212> PRT
      <213> Homo sapiens


      <400> 1286
 Met Ala Val Pro Ala Lys Lys Arg Lys Met Asn Phe Ser Glu Arg Glu
   1               5                  10                  15    
 Val Glu Ile Ile Val Glu Glu Leu Glu Leu Lys Lys His Leu Leu Val
              20                  25                  30        
 Asn His Phe Asn Ala Gly Val Pro Leu Ala Ala Lys Ser Ala Ala Trp
          35                  40                  45            
 His Gly Ile Leu Arg Arg Val Asn Ala Val Ala Thr Cys Arg Arg Glu
      50                  55                  60                
 Leu Pro Glu Val Lys Lys Lys Trp Ser Asp Leu Lys Thr Glu Val Arg
  65                  70                  75                  80
 Arg Lys Val Ala Gln Val Arg Ala Ala Val Glu Gly Gly Glu Ala Pro
                  85                  90                  95    
 Gly Pro Thr Glu Glu Asp Gly Ala Gly Gly Pro Gly Thr Gly Gly Gly
             100                 105                 110        
 Ser Gly Gly Gly Gly Pro Ala Val Ala Pro Val Leu Leu Thr Pro Met
         115                 120                 125            
 Gln Gln Arg Ile Cys Asn Leu Leu Gly Glu Ala Thr Ile Ile Ser Leu
     130                 135                 140                
 Pro Ser Thr Thr Glu Ile His Pro Val Ala Leu Gly Pro Ser Ala Thr
 145                 150                 155                 160
 Ala Ala Ala Ala Thr Val Thr Leu Thr Gln Ile Pro Thr Glu Thr Thr
                 165                 170                 175    
 Tyr His Thr Leu Glu Glu Gly Val Val Glu Tyr Cys Thr Ala Glu Ala
             180                 185                 190        
 Pro Pro Pro Leu Pro Pro Glu Thr Pro Val Asp Met Met Ala Gln His
         195                 200                 205            
 Ala Asp Thr Ser Val Lys Pro Gln Ala Leu Lys Ser Arg Ile Ala Leu
     210                 215                 220                
 Asn Ser Ala Lys Leu Ile Gln Glu Gln Arg Val Thr Asn Leu His Val
 225                 230                 235                 240
 Lys Glu Ile Ala Gln His Leu Glu Gln Gln Asn Asp Leu Leu Gln Met
                 245                 250                 255    
 Ile Arg Arg Ser Gln Glu Val Gln Ala Cys Ala Gln Glu Arg Gln Ala
             260                 265                 270        
 Gln Ala Met Glu Gly Thr Gln Ala Ala Leu Ser Val Leu Ile Gln Val
         275                 280                 285            
 Leu Arg Pro Met Ile Lys Asp Phe Arg Arg Tyr Leu Gln Ser Asn Thr
     290                 295                 300                
 Ala Asn Pro Ala Pro Ala Ser Asp Pro Gly Gln Val Ala Gln Asn Gly
 305                 310                 315                 320
 Gln Pro Asp Ser Ile Ile Gln
                 325        



      <210> 1287
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 1287
 Met Leu Phe Gly Ile Arg Ile Leu Val Asn Thr Pro Ser Pro Leu Val
   1               5                  10                  15    
 Thr Gly Leu His His Tyr Asn Pro Ser Ile His Arg Asp Gln Gly Glu
              20                  25                  30        
 Cys Ala Asn Gln Trp Arg Lys Gly Arg Gly Ser Ala His Leu Ala Gly
          35                  40                  45            
 Leu Ala Gly Arg Cys Ser Leu Ile Asn Thr Pro Ser Pro Leu Val Thr
      50                  55                  60                
 Gly Leu Gln Arg Tyr Asn Pro Ser Met Asp Arg Ala Gln Gly Met Cys
  65                  70                  75                  80
 Ala Ser Leu Glu Glu Glu Ala Gly Leu Cys Lys Pro Leu Trp Ala Trp
                  85                  90                  95    
 Trp Glu Leu Gln Ser His Lys His Ser Gln Thr Ser His His Arg Ala
             100                 105                 110        
 Ala Gly Leu Gln Ser Gln His Ala Pro Gly Ser Gly Arg Val Arg Ile
         115                 120                 125            
 Thr Gly Gly Lys Val
     130            



      <210> 1288
      <211> 503
      <212> PRT
      <213> Homo sapiens


      <400> 1288
 Met Ala Pro Gly Pro Phe Ser Ser Ala Leu Leu Ser Pro Pro Pro Ala
   1               5                  10                  15    
 Ala Leu Pro Phe Leu Leu Leu Leu Trp Ala Gly Ala Ser Arg Gly Gln
              20                  25                  30        
 Pro Cys Pro Gly Arg Cys Ile Cys Gln Asn Val Ala Pro Thr Leu Thr
          35                  40                  45            
 Met Leu Cys Ala Lys Thr Gly Leu Leu Phe Val Pro Pro Ala Ile Asp
      50                  55                  60                
 Arg Arg Val Val Glu Leu Arg Leu Thr Asp Asn Phe Ile Ala Ala Val
  65                  70                  75                  80
 Arg Arg Arg Asp Phe Ala Asn Met Thr Ser Leu Val His Leu Thr Leu
                  85                  90                  95    
 Ser Arg Asn Thr Ile Gly Gln Val Ala Ala Gly Ala Phe Ala Asp Leu
             100                 105                 110        
 Arg Ala Leu Arg Ala Leu His Leu Asp Ser Asn Arg Leu Ala Glu Val
         115                 120                 125            
 Arg Gly Asp Gln Leu Arg Gly Leu Gly Asn Leu Arg His Leu Ile Leu
     130                 135                 140                
 Gly Asn Asn Gln Ile Arg Arg Val Glu Ser Ala Ala Phe Asp Ala Phe
 145                 150                 155                 160
 Leu Ser Thr Val Glu Asp Leu Asp Leu Ser Tyr Asn Asn Leu Glu Ala
                 165                 170                 175    
 Leu Pro Trp Glu Ala Val Gly Gln Met Val Asn Leu Asn Thr Leu Thr
             180                 185                 190        
 Leu Asp His Asn Leu Ile Asp His Ile Ala Glu Gly Thr Phe Val Gln
         195                 200                 205            
 Leu His Lys Leu Val Arg Leu Asp Met Thr Ser Asn Arg Leu His Lys
     210                 215                 220                
 Leu Pro Pro Asp Gly Leu Phe Leu Arg Ser Gln Gly Thr Gly Pro Lys
 225                 230                 235                 240
 Pro Pro Thr Pro Leu Thr Val Ser Phe Gly Gly Asn Pro Leu His Cys
                 245                 250                 255    
 Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Thr Arg Glu Asp Asp Leu
             260                 265                 270        
 Glu Thr Cys Ala Thr Pro Glu His Leu Thr Asp Arg Tyr Phe Trp Ser
         275                 280                 285            
 Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu Ile Thr Arg Gln
     290                 295                 300                
 Ala Gly Gly Arg Ala Leu Val Val Glu Gly Gln Ala Val Ser Leu Arg
 305                 310                 315                 320
 Cys Arg Ala Val Gly Asp Pro Glu Pro Val Val His Trp Val Ala Pro
                 325                 330                 335    
 Asp Gly Arg Leu Leu Gly Asn Ser Ser Arg Thr Arg Val Arg Gly Asp
             340                 345                 350        
 Gly Thr Leu Asp Val Thr Ile Thr Thr Leu Arg Asp Ser Gly Thr Phe
         355                 360                 365            
 Thr Cys Ile Ala Ser Asn Ala Ala Gly Glu Ala Thr Ala Pro Val Glu
     370                 375                 380                
 Val Cys Val Val Pro Leu Pro Leu Met Ala Pro Pro Pro Ala Ala Pro
 385                 390                 395                 400
 Pro Pro Leu Thr Glu Pro Gly Ser Ser Asp Ile Ala Thr Pro Gly Arg
                 405                 410                 415    
 Pro Gly Ala Asn Asp Ser Ala Ala Glu Arg Arg Leu Val Ala Ala Glu
             420                 425                 430        
 Leu Thr Ser Asn Ser Val Leu Ile Arg Trp Pro Ala Gln Arg Pro Val
         435                 440                 445            
 Pro Gly Ile Arg Met Tyr Gln Val Gln Tyr Asn Ser Ser Val Asp Asp
     450                 455                 460                
 Ser Leu Val Leu Gln Val Gly Ala Gly Ala Ala Val Pro Gly Pro Pro
 465                 470                 475                 480
 Pro Lys Pro Arg Gly Thr Leu Pro Pro Thr Cys Pro Phe Pro Trp Pro
                 485                 490                 495    
 Ser Cys Ser Ala Arg Val Leu
             500            



      <210> 1289
      <211> 1094
      <212> PRT
      <213> Homo sapiens


      <400> 1289
 Met Ala Ala Arg Gln Ala Val Gly Ser Gly Ala Gln Glu Thr Cys Gly
   1               5                  10                  15    
 Leu Asp Arg Ile Leu Glu Ala Leu Lys Leu Leu Leu Ser Pro Gly Gly
              20                  25                  30        
 Ser Gly Ser Ser Ser Leu Gln Val Thr Lys His Asp Val Leu Leu Ala
          35                  40                  45            
 Thr Leu Lys Ser Asn Leu Ser Ala Leu Glu Asp Lys Phe Leu Lys Asp
      50                  55                  60                
 Pro Gln Trp Lys Asn Leu Lys Leu Leu Arg Asp Glu Ile Ala Asp Lys
  65                  70                  75                  80
 Ala Glu Trp Pro Gln Asn Ser Val Asp Val Thr Trp Ser Phe Thr Ser
                  85                  90                  95    
 Gln Thr Leu Leu Leu Leu Leu Cys Leu Lys Glu Thr Met Ile Arg Leu
             100                 105                 110        
 Ala Ala Asn Phe Asn Pro Gly Lys Pro Asn Pro Arg Thr Pro Glu Val
         115                 120                 125            
 Ala Pro Ala Leu Ser Pro Asp Ala Leu Ser Ile Ser Gln Gln Lys Thr
     130                 135                 140                
 Val Gln Phe Val Leu Gln Phe Val Val Thr Leu Gly Ile Cys Pro Tyr
 145                 150                 155                 160
 Leu Met Pro Gly Val Gly Val Pro Leu Arg Tyr Arg Thr Glu Phe Gly
                 165                 170                 175    
 Ala Val Val Gln Asp Val Val Cys Phe Asp Ala Ala Pro Asp Ala Thr
             180                 185                 190        
 Arg Arg Leu Tyr Thr Ser Cys Lys Ala Leu Leu Asn Val Ala Gln His
         195                 200                 205            
 Thr Ser Leu Gly Ser Leu Ile Phe Cys His His Phe Gly Asp Ile Ala
     210                 215                 220                
 Ala Gly Leu Cys Gln Leu Gly Phe Cys Pro Thr Lys Arg Lys Leu Leu
 225                 230                 235                 240
 Thr Pro Ala Glu Glu Val Leu Thr Glu Glu Glu Arg Thr Leu Ser Arg
                 245                 250                 255    
 Gly Ala Leu Arg Asp Met Leu Asp Gln Val Tyr Gln Pro Leu Ala Val
             260                 265                 270        
 Arg Glu Leu Leu Ile Leu Gln Gly Gly Pro Pro Gln Ser Cys Thr Asp
         275                 280                 285            
 Val Lys Thr Gln Met Arg Cys Arg Ala Pro Ala Trp Leu Arg Arg Leu
     290                 295                 300                
 Cys Gly Gln Leu Leu Ser Glu Arg Leu Met Arg Pro Asn Gly Val Gln
 305                 310                 315                 320
 Ala Val Val Arg Gly Ile Leu Glu Gly Ala Gly Ala Gly Ala Ala Gly
                 325                 330                 335    
 Gly Ser Asp Ala Glu Val Thr Ala Ala Asp Trp Lys Lys Cys Asp Leu
             340                 345                 350        
 Ile Ala Lys Ile Leu Ala Ser Cys Pro Gln Gln Ser Leu Ser Pro Glu
         355                 360                 365            
 Asn Tyr Tyr Arg Asp Ile Cys Pro Gln Val Leu Asp Leu Phe His Phe
     370                 375                 380                
 Gln Asp Lys Leu Thr Ala Arg Gln Phe Gln Arg Val Ala Thr Thr Thr
 385                 390                 395                 400
 Phe Ile Thr Leu Ser Arg Glu Arg Pro His Leu Ala Ala Lys Tyr Leu
                 405                 410                 415    
 Leu Gln Pro Val Leu Ala Pro Leu His Arg Cys Leu Asn Thr Ala Glu
             420                 425                 430        
 Leu Ser Glu Ser Asp Met Val Pro Gly Thr Ile Leu Val Thr Glu Glu
         435                 440                 445            
 Glu Leu Ser Arg Cys Ile Glu Asp Val Phe Lys Val Tyr Val Val Gly
     450                 455                 460                
 Asn Glu Pro Leu Thr Val Leu Met Asp Ser Leu Leu Pro Val Leu Gly
 465                 470                 475                 480
 Val Leu Phe Leu Leu Tyr Cys Phe Thr Lys Gln Ser Val Ser His Ile
                 485                 490                 495    
 Arg Ser Leu Cys Gln Glu Ile Leu Leu Trp Ile Leu Gly Lys Leu Glu
             500                 505                 510        
 Arg Lys Lys Ala Ile Ala Ser Leu Lys Gly Phe Ala Gly Leu Asp Lys
         515                 520                 525            
 Ala Val Pro Ser Leu His Ser Leu Cys Gln Phe Arg Val Ala Thr Gln
     530                 535                 540                
 Gly Gly Ile Met Ile Thr Ile Lys Glu Ala Ile Ser Asp Glu Asp Glu
 545                 550                 555                 560
 Asp Glu Ala Leu Tyr Gln Lys Val Ser Ser Glu Gln Gly Arg Val Glu
                 565                 570                 575    
 His Leu Gly Asp Leu Leu Ser His Cys Gln Glu Cys Gly Leu Ala Gly
             580                 585                 590        
 Asp Phe Phe Ile Phe Cys Leu Lys Glu Leu Thr His Val Ala Ser Glu
         595                 600                 605            
 Asn Glu Thr Glu Leu Lys Thr Glu Pro Phe Ser Ser Lys Ser Leu Leu
     610                 615                 620                
 Glu Leu Glu Gln His Gln Thr Leu Leu Val Glu Gly Gln Glu Arg Lys
 625                 630                 635                 640
 Leu Leu Val Leu Gln Leu Met Ala Val Leu Cys Glu Arg Met Ser Glu
                 645                 650                 655    
 Gln Ile Phe Thr Asn Val Thr Gln Val Val Asp Phe Val Ala Ala Thr
             660                 665                 670        
 Leu Gln Arg Ala Cys Ala Ser Leu Ala His Gln Ala Glu Ser Thr Val
         675                 680                 685            
 Glu Ser Gln Thr Leu Ser Met Ser Met Gly Leu Val Ala Val Met Leu
     690                 695                 700                
 Gly Gly Ala Val Gln Leu Lys Ser Ser Asp Phe Ala Val Leu Lys Gln
 705                 710                 715                 720
 Leu Leu Pro Leu Leu Glu Lys Val Ser Asn Thr Tyr Pro Asp Pro Val
                 725                 730                 735    
 Ile Gln Glu Leu Ala Val Asp Leu Arg Ile Thr Ile Ser Thr His Gly
             740                 745                 750        
 Ala Phe Ala Thr Glu Ala Val Ser Met Ala Ala Gln Ser Thr Leu Asn
         755                 760                 765            
 Arg Lys Asp Leu Glu Gly Lys Ile Glu Glu Gln Gln Gln Thr Ser His
     770                 775                 780                
 Glu Arg Pro Thr Asp Val Ala His Ser His Leu Glu Gln Gln Gln Ser
 785                 790                 795                 800
 His Glu Thr Ala Pro Gln Thr Gly Leu Gln Ser Asn Ala Pro Ile Ile
                 805                 810                 815    
 Pro Gln Gly Val Asn Glu Pro Ser Thr Thr Thr Ser Gln Lys Ser Gly
             820                 825                 830        
 Ser Val Thr Thr Glu Gln Leu Gln Glu Val Leu Leu Ser Ala Tyr Asp
         835                 840                 845            
 Pro Gln Ile Pro Thr Arg Ala Ala Ala Leu Arg Thr Leu Ser His Trp
     850                 855                 860                
 Ile Glu Gln Arg Glu Ala Lys Ala Leu Glu Met Gln Glu Lys Leu Leu
 865                 870                 875                 880
 Lys Ile Phe Leu Glu Asn Leu Glu His Glu Asp Thr Phe Val Tyr Leu
                 885                 890                 895    
 Ser Ala Ile Gln Gly Val Ala Leu Leu Ser Asp Val Tyr Pro Glu Lys
             900                 905                 910        
 Ile Leu Pro Asp Leu Leu Ala Gln Tyr Asp Ser Ser Lys Asp Lys His
         915                 920                 925            
 Thr Pro Glu Thr Arg Met Lys Val Gly Glu Val Leu Met Arg Ile Val
     930                 935                 940                
 Arg Ala Leu Gly Asp Met Val Ser Lys Tyr Arg Glu Pro Leu Ile His
 945                 950                 955                 960
 Thr Phe Leu Arg Gly Val Arg Asp Pro Asp Gly Ala His Arg Ala Ser
                 965                 970                 975    
 Ser Leu Ala Asn Leu Gly Glu Leu Cys Gln Arg Leu Asp Phe Leu Leu
             980                 985                 990        
 Gly Ser Val Val His Glu Val Thr Ala Cys Leu Ile Ala Val Ala Lys
         995                1000                1005            
 Thr Asp Gly Glu Val Gln Val Arg Arg Ala Ala Ile His Val Val Val
    1010                1015                1020                
 Leu Leu Leu Arg Gly Leu Ser Gln Lys Ala Thr Glu Val Leu Ser Ala
1025                1030                1035                1040
 Val Leu Lys Asp Leu Tyr His Leu Leu Lys His Val Val Cys Leu Glu
                1045                1050                1055    
 Pro Asp Asp Val Ala Lys Leu His Ala Gln Leu Ala Leu Glu Glu Leu
            1060                1065                1070        
 Asp Asp Ile Met Lys Asn Phe Leu Phe Pro Pro Gln Lys Leu Glu Lys
        1075                1080                1085            
 Lys Ile Met Val Leu Pro
    1090                



      <210> 1290
      <211> 246
      <212> PRT
      <213> Homo sapiens


      <400> 1290
 Met Ala Met Leu Pro Thr Ala Gly His Leu Leu Pro Leu Leu Leu Val
   1               5                  10                  15    
 Ile Gly Thr Gly Gly Thr Val Pro Ser Pro Gln Val Pro Pro Arg Gly
              20                  25                  30        
 Cys Tyr Val Ala Lys Glu Ala Gly Glu Arg Thr Phe Arg Cys Ser Gln
          35                  40                  45            
 Ala Gly Leu Ser Ala Val Pro Ser Gly Ile Pro Asn Asp Thr Arg Lys
      50                  55                  60                
 Leu Tyr Leu Asp Ala Asn Gln Leu Ala Ser Val Pro Ala Gly Ala Phe
  65                  70                  75                  80
 Gln His Leu Pro Val Leu Glu Glu Leu Asp Leu Ser His Asn Ala Leu
                  85                  90                  95    
 Ala His Leu Ser Gly Ala Ala Phe Gln Gly Leu Glu Gly Thr Leu Arg
             100                 105                 110        
 His Leu Asp Leu Ser Ala Asn Gln Leu Ala Ser Ile Gln Val Asn Leu
         115                 120                 125            
 Ser Ala Asn Pro Trp His Cys Asp Cys Ala Leu Gln Glu Val Leu Arg
     130                 135                 140                
 Gln Val Arg Leu Val Pro Gly Thr Gly Thr Gly Ile Val Cys Gly Ser
 145                 150                 155                 160
 Gly Ala Arg Pro Asp Leu Val Gly Gln Glu Phe Leu Leu Leu Ala Gly
                 165                 170                 175    
 Glu Glu Glu Leu Cys Gly Ser Gly Trp Gly Gly Ala Arg Arg Ser Thr
             180                 185                 190        
 Asp Val Ala Leu Leu Val Thr Met Gly Gly Trp Leu Thr Leu Met Val
         195                 200                 205            
 Ala Tyr Leu Val His Tyr Val Trp Gln Asn Arg Asp Glu Thr Arg Arg
     210                 215                 220                
 Ser Leu Lys Arg Ala Pro Val Leu Pro Val Arg Ser Glu Asp Ser Ser
 225                 230                 235                 240
 Ile Leu Ser Thr Val Val
                 245    



      <210> 1291
      <211> 536
      <212> PRT
      <213> Homo sapiens


      <400> 1291
 Met Glu Trp Gly Arg Arg Val Phe Cys Val Glu Met Pro Ala Glu Gly
   1               5                  10                  15    
 Arg Gly Val Phe Thr Asp Ala Cys Ser Val Pro Val Ser Glu Ile Ile
              20                  25                  30        
 Ala Val Glu Glu Thr Asp Val His Gly Lys His Gln Gly Ser Gly Lys
          35                  40                  45            
 Trp Gln Lys Met Glu Lys Pro Tyr Ala Phe Thr Val His Cys Val Lys
      50                  55                  60                
 Arg Ala Arg Arg His Arg Trp Lys Trp Ala Gln Val Thr Phe Trp Cys
  65                  70                  75                  80
 Pro Glu Glu Gln Leu Cys His Leu Trp Leu Gln Thr Leu Arg Glu Met
                  85                  90                  95    
 Leu Glu Lys Leu Ile Thr Glu His Ala Asn Gln Ala Lys Glu Thr Leu
             100                 105                 110        
 Tyr Glu Ile Asn Ile Asp Lys Tyr Asp Gly Ile Val Cys Val Gly Gly
         115                 120                 125            
 Asp Gly Met Phe Ser Glu Val Leu His Gly Leu Ile Gly Arg Thr Gln
     130                 135                 140                
 Arg Ser Ala Gly Val Asp Gln Asn His Pro Arg Ala Val Leu Val Pro
 145                 150                 155                 160
 Ser Ser Leu Arg Ile Gly Ile Ile Pro Ala Gly Phe Ala Asn Asp Leu
                 165                 170                 175    
 Ala Gly Asp Glu Val Ser Val Leu Ser Gly Pro Val Ser Gly Pro Glu
             180                 185                 190        
 Gly Gly Gly Met Val His Thr Phe Thr Leu Val Thr Ala Leu Gly Cys
         195                 200                 205            
 Glu His Arg Ser His Pro His Phe Met Asp Glu Asp Arg Arg Thr Gly
     210                 215                 220                
 Glu His Val Gly Pro Gly Glu Asn Ala Gly Gly Leu Asp Gly Ser Thr
 225                 230                 235                 240
 Asp Cys Val Cys Tyr Ser Thr Val Gly Thr Ser Asp Ala Glu Thr Ser
                 245                 250                 255    
 Ala Leu His Ile Val Val Gly Asp Ser Leu Ala Met Asp Val Ser Ser
             260                 265                 270        
 Val His His Asn Ser Thr Leu Leu Arg Tyr Ser Val Ser Leu Leu Gly
         275                 280                 285            
 Tyr Gly Phe Tyr Gly Asp Ile Ile Lys Asp Ser Glu Lys Lys Arg Trp
     290                 295                 300                
 Leu Gly Leu Ala Arg Tyr Asp Phe Ser Gly Leu Lys Thr Phe Leu Ser
 305                 310                 315                 320
 His His Cys Tyr Glu Gly Thr Val Ser Phe Leu Pro Ala Gln His Thr
                 325                 330                 335    
 Val Gly Ser Pro Arg Asp Arg Lys Pro Cys Arg Ala Gly Cys Phe Val
             340                 345                 350        
 Cys Arg Gln Ser Lys Gln Gln Leu Glu Glu Glu Gln Lys Lys Ala Leu
         355                 360                 365            
 Tyr Gly Leu Glu Ala Ala Glu Asp Val Glu Glu Trp Gln Val Val Cys
     370                 375                 380                
 Gly Lys Phe Leu Ala Ile Asn Ala Thr Asn Met Ser Cys Ala Cys Arg
 385                 390                 395                 400
 Arg Ser Pro Arg Gly Leu Ser Pro Ala Ala His Leu Gly Asp Gly Ser
                 405                 410                 415    
 Ser Asp Leu Ile Leu Ile Arg Lys Cys Ser Arg Phe Asn Phe Leu Arg
             420                 425                 430        
 Phe Leu Ile Arg His Thr Asn Gln Gln Asp Gln Phe Asp Phe Thr Phe
         435                 440                 445            
 Val Glu Val Tyr Arg Val Lys Lys Phe Gln Phe Thr Ser Lys His Met
     450                 455                 460                
 Glu Asp Glu Asp Ser Asp Leu Lys Glu Gly Gly Lys Lys Arg Phe Gly
 465                 470                 475                 480
 His Ile Cys Ser Ser His Pro Ser Cys Cys Cys Thr Val Ser Asn Ser
                 485                 490                 495    
 Ser Trp Asn Cys Asp Gly Glu Val Leu His Ser Pro Ala Ile Glu Val
             500                 505                 510        
 Arg Val His Cys Gln Leu Val Arg Leu Phe Ala Arg Gly Ile Glu Glu
         515                 520                 525            
 Asn Pro Lys Pro Asp Ser His Ser
     530                 535    



      <210> 1292
      <211> 270
      <212> PRT
      <213> Homo sapiens


      <400> 1292
 Met Lys Arg Glu Arg Gly Ala Leu Ser Arg Ala Ser Arg Ala Leu Arg
   1               5                  10                  15    
 Leu Ala Pro Phe Val Tyr Leu Leu Leu Ile Gln Thr Asp Pro Leu Glu
              20                  25                  30        
 Gly Val Asn Ile Thr Ser Pro Val Arg Leu Ile His Gly Thr Val Gly
          35                  40                  45            
 Lys Ser Ala Leu Leu Ser Val Gln Tyr Ser Ser Thr Ser Ser Asp Arg
      50                  55                  60                
 Pro Val Val Lys Trp Gln Leu Lys Arg Asp Lys Pro Val Thr Val Val
  65                  70                  75                  80
 Gln Ser Ile Gly Thr Glu Val Ile Gly Thr Leu Arg Pro Asp Tyr Arg
                  85                  90                  95    
 Asp Arg Ile Arg Leu Phe Glu Asn Gly Ser Leu Leu Leu Ser Asp Leu
             100                 105                 110        
 Gln Leu Ala Asp Glu Gly Thr Tyr Glu Val Glu Ile Ser Ile Thr Asp
         115                 120                 125            
 Asp Thr Phe Thr Gly Glu Lys Thr Ile Asn Leu Thr Val Asp Val Pro
     130                 135                 140                
 Ile Ser Arg Pro Gln Val Leu Val Ala Ser Thr Thr Val Leu Glu Leu
 145                 150                 155                 160
 Ser Glu Ala Phe Thr Leu Asn Cys Ser His Glu Asn Gly Thr Lys Pro
                 165                 170                 175    
 Ser Tyr Thr Trp Leu Lys Asp Gly Lys Pro Leu Leu Asn Asp Ser Arg
             180                 185                 190        
 Met Leu Leu Ser Pro Asp Gln Lys Val Leu Thr Ile Thr Arg Val Leu
         195                 200                 205            
 Met Glu Asp Asp Asp Leu Tyr Ser Cys Met Val Glu Asn Pro Ile Ser
     210                 215                 220                
 Gln Gly Arg Ser Leu Pro Val Lys Ile Thr Val Tyr Arg Arg Ser Ser
 225                 230                 235                 240
 Leu Tyr Ile Ile Leu Ser Thr Gly Gly Ile Phe Leu Leu Val Thr Leu
                 245                 250                 255    
 Val Thr Val Cys Ala Cys Trp Lys Pro Ser Lys Arg Ser Gly
             260                 265                 270



      <210> 1293
      <211> 416
      <212> PRT
      <213> Homo sapiens


      <400> 1293
 Met Lys Arg Glu Arg Gly Ala Leu Ser Arg Ala Ser Arg Ala Leu Arg
   1               5                  10                  15    
 Leu Ala Pro Phe Val Tyr Leu Leu Leu Ile Gln Thr Asp Pro Leu Glu
              20                  25                  30        
 Gly Val Asn Ile Thr Ser Pro Val Arg Leu Ile His Gly Thr Val Gly
          35                  40                  45            
 Lys Ser Ala Leu Leu Ser Val Gln Tyr Ser Ser Thr Ser Ser Asp Arg
      50                  55                  60                
 Pro Val Val Lys Trp Gln Leu Lys Arg Asp Lys Pro Val Thr Val Val
  65                  70                  75                  80
 Gln Ser Ile Gly Thr Glu Val Ile Gly Thr Leu Arg Pro Asp Tyr Arg
                  85                  90                  95    
 Asp Arg Ile Arg Leu Phe Glu Asn Gly Ser Leu Leu Leu Ser Asp Leu
             100                 105                 110        
 Gln Leu Ala Asp Glu Gly Thr Tyr Glu Val Glu Ile Ser Ile Thr Asp
         115                 120                 125            
 Asp Thr Phe Thr Gly Glu Lys Thr Ile Asn Leu Thr Val Asp Val Pro
     130                 135                 140                
 Ile Ser Arg Pro Gln Val Leu Val Ala Ser Thr Thr Val Leu Glu Leu
 145                 150                 155                 160
 Ser Glu Ala Phe Thr Leu Asn Cys Ser His Glu Asn Gly Thr Lys Pro
                 165                 170                 175    
 Ser Tyr Thr Trp Leu Lys Asp Gly Lys Pro Leu Leu Asn Asp Ser Arg
             180                 185                 190        
 Met Leu Leu Ser Pro Asp Gln Lys Val Leu Thr Ile Thr Arg Val Leu
         195                 200                 205            
 Met Glu Asp Asp Asp Leu Tyr Ser Cys Met Val Glu Asn Pro Ile Ser
     210                 215                 220                
 Gln Gly Arg Ser Leu Pro Val Lys Ile Thr Val Tyr Arg Arg Ser Ser
 225                 230                 235                 240
 Leu Tyr Ile Ile Leu Ser Thr Gly Gly Ile Phe Leu Leu Val Thr Leu
                 245                 250                 255    
 Val Thr Val Cys Ala Cys Trp Lys Pro Ser Lys Arg Lys Gln Lys Lys
             260                 265                 270        
 Leu Glu Lys Gln Asn Ser Leu Glu Tyr Met Asp Gln Asn Asp Asp Arg
         275                 280                 285            
 Leu Lys Pro Glu Ala Asp Thr Leu Pro Arg Ser Gly Glu Gln Glu Arg
     290                 295                 300                
 Lys Asn Pro Met Ala Leu Tyr Ile Leu Lys Asp Lys Asp Ser Pro Glu
 305                 310                 315                 320
 Thr Glu Glu Asn Pro Ala Pro Glu Pro Arg Ser Ala Thr Glu Pro Gly
                 325                 330                 335    
 Pro Pro Gly Tyr Ser Val Ser Pro Ala Val Pro Gly Arg Ser Pro Gly
             340                 345                 350        
 Leu Pro Ile Arg Ser Ala Arg Arg Tyr Pro Arg Ser Pro Ala Arg Ser
         355                 360                 365            
 Pro Ala Thr Gly Arg Thr His Ser Ser Pro Pro Arg Ala Pro Ser Ser
     370                 375                 380                
 Pro Gly Arg Ser Arg Ser Ala Ser Arg Thr Leu Arg Thr Ala Gly Val
 385                 390                 395                 400
 His Ile Ile Arg Glu Gln Asp Glu Ala Gly Pro Val Glu Ile Ser Ala
                 405                 410                 415    





      <210> 1294
      <211> 384
      <212> PRT
      <213> Homo sapiens


      <400> 1294
 Met Ala Phe Leu Met Lys Lys Lys Lys Phe Lys Phe Gln Thr Thr Phe
   1               5                  10                  15    
 Thr Leu Glu Glu Leu Thr Ala Val Pro Phe Val Asn Gly Val Leu Phe
              20                  25                  30        
 Cys Lys Val Arg Leu Leu Asp Gly Gly Asp Phe Val Ser Leu Ser Ser
          35                  40                  45            
 Arg Glu Glu Val Gln Glu Asn Cys Val Arg Trp Arg Lys Arg Phe Thr
      50                  55                  60                
 Phe Val Cys Lys Met Ser Ala Asn Pro Ala Thr Gly Leu Leu Asp Pro
  65                  70                  75                  80
 Cys Val Phe Arg Val Ser Val Arg Lys Glu Leu Lys Gly Gly Lys Ala
                  85                  90                  95    
 Tyr Ser Lys Leu Gly Phe Ala Asp Leu Asn Leu Ala Glu Phe Ala Gly
             100                 105                 110        
 Ser Gly Ser Thr Val Arg Cys Cys Leu Leu Glu Gly Tyr Asp Thr Lys
         115                 120                 125            
 Asn Thr Arg Gln Asp Asn Ser Ile Leu Lys Val Thr Ile Gly Met Phe
     130                 135                 140                
 Leu Leu Ser Gly Asp Pro Cys Phe Lys Thr Pro Pro Ser Thr Ala Lys
 145                 150                 155                 160
 Ser Ile Ser Ile Pro Gly Gln Asp Ser Ser Leu Gln Leu Thr Cys Lys
                 165                 170                 175    
 Gly Gly Gly Thr Ser Ser Gly Gly Ser Ser Thr Asn Ser Leu Thr Gly
             180                 185                 190        
 Ser Arg Pro Pro Lys Ala Arg Pro Thr Ile Leu Ser Ser Gly Leu Pro
         195                 200                 205            
 Glu Glu Pro Asp Gln Asn Leu Ser Ser Pro Glu Glu Val Phe His Ser
     210                 215                 220                
 Gly His Ser Arg Asn Ser Ser Tyr Ala Ser Gln Gln Ser Lys Ile Ser
 225                 230                 235                 240
 Gly Tyr Ser Thr Glu His Ser Arg Ser Ser Ser Leu Ser Asp Leu Thr
                 245                 250                 255    
 His Arg Arg Asn Thr Ser Thr Ser Ser Ser Ala Ser Gly Gly Leu Gly
             260                 265                 270        
 Met Thr Val Glu Gly Pro Glu Gly Ser Glu Arg Glu His Arg Pro Pro
         275                 280                 285            
 Glu Lys Pro Pro Arg Pro Pro Arg Pro Leu His Leu Ser Asp Arg Ser
     290                 295                 300                
 Phe Arg Arg Lys Lys Asp Ser Val Glu Ser His Pro Ala Trp Val Asp
 305                 310                 315                 320
 Asp Thr Arg Ile Asp Ala Asp Ala Ile Val Glu Lys Ile Val Gln Ser
                 325                 330                 335    
 Gln Asp Phe Thr Asp Gly Ser Asn Thr Glu Asp Ser Asn Leu Arg Leu
             340                 345                 350        
 Phe Val Ser Arg Asp Gly Ser Ala Thr Leu Ser Gly Ile Gln Leu Ala
         355                 360                 365            
 Thr Arg Val Ser Ser Gly Val Tyr Glu Pro Val Val Ile Glu Ser His
     370                 375                 380                





      <210> 1295
      <211> 201
      <212> PRT
      <213> Homo sapiens


      <400> 1295
 Met Gly Ser Gly Arg Arg Ala Leu Ser Ala Val Pro Ala Val Leu Leu
   1               5                  10                  15    
 Val Leu Thr Leu Pro Gly Leu Pro Val Trp Ala Gln Asn Asp Thr Glu
              20                  25                  30        
 Pro Ile Val Leu Glu Gly Lys Cys Leu Val Val Cys Asp Ser Asn Pro
          35                  40                  45            
 Ala Thr Asp Ser Lys Gly Ser Ser Ser Ser Pro Leu Gly Ile Ser Val
      50                  55                  60                
 Arg Ala Ala Asn Ser Lys Val Ala Phe Ser Ala Val Arg Ser Thr Asn
  65                  70                  75                  80
 His Glu Pro Ser Glu Met Ser Asn Lys Thr Arg Ile Ile Tyr Phe Asp
                  85                  90                  95    
 Gln Ile Leu Val Asn Val Gly Asn Phe Phe Thr Leu Glu Ser Val Phe
             100                 105                 110        
 Val Ala Pro Arg Lys Gly Ile Tyr Ser Phe Ser Phe His Val Ile Lys
         115                 120                 125            
 Val Tyr Gln Ser Gln Thr Ile Gln Val Asn Leu Met Leu Asn Gly Lys
     130                 135                 140                
 Pro Val Ile Ser Ala Phe Ala Gly Asp Lys Asp Val Thr Arg Glu Ala
 145                 150                 155                 160
 Ala Thr Asn Gly Val Leu Leu Tyr Leu Asp Lys Glu Asp Lys Val Tyr
                 165                 170                 175    
 Leu Lys Leu Glu Lys Gly Asn Leu Val Gly Gly Trp Gln Tyr Ser Thr
             180                 185                 190        
 Phe Ser Gly Phe Leu Val Phe Pro Leu
         195                 200    



      <210> 1296
      <211> 384
      <212> PRT
      <213> Homo sapiens


      <400> 1296
 Met Glu Thr Ser Ser Pro Arg Pro Pro Arg Pro Ser Ser Asn Pro Gly
   1               5                  10                  15    
 Leu Ser Leu Asp Ala Arg Leu Gly Val Asp Thr Arg Leu Trp Ala Lys
              20                  25                  30        
 Val Leu Phe Thr Ala Leu Tyr Ala Leu Ile Trp Ala Leu Gly Ala Ala
          35                  40                  45            
 Gly Asn Ala Leu Ser Val His Val Val Leu Lys Ala Arg Ala Gly Arg
      50                  55                  60                
 Ala Gly Arg Leu Arg His His Val Leu Ser Leu Ala Leu Ala Gly Leu
  65                  70                  75                  80
 Leu Leu Leu Leu Val Gly Val Pro Val Glu Leu Tyr Ser Phe Val Trp
                  85                  90                  95    
 Phe His Tyr Pro Trp Val Phe Gly Asp Leu Gly Cys Leu Ala Val Cys
             100                 105                 110        
 Gln Pro Leu Arg Ala Arg Ser Leu Leu Thr Pro Arg Arg Thr Arg Trp
         115                 120                 125            
 Leu Val Ala Leu Ser Trp Ala Ala Ser Leu Gly Leu Ala Leu Pro Met
     130                 135                 140                
 Ala Val Ile Met Gly Gln Lys His Glu Leu Glu Thr Ala Asp Gly Glu
 145                 150                 155                 160
 Pro Glu Pro Ala Ser Arg Val Cys Thr Val Leu Val Ser Arg Thr Ala
                 165                 170                 175    
 Leu Gln Val Phe Ile Gln Val Asn Val Leu Val Ser Phe Val Leu Pro
             180                 185                 190        
 Leu Ala Leu Thr Ala Phe Leu Asn Gly Val Thr Val Ser His Leu Leu
         195                 200                 205            
 Ala Leu Cys Ser Gln Val Pro Ser Thr Ser Thr Pro Gly Ser Ser Thr
     210                 215                 220                
 Pro Ser Arg Leu Glu Leu Leu Ser Glu Glu Gly Leu Leu Ser Phe Ile
 225                 230                 235                 240
 Val Trp Lys Lys Thr Phe Ile Gln Gly Gly Gln Val Ser Leu Val Arg
                 245                 250                 255    
 His Lys Asp Val Arg Arg Ile Arg Ser Leu Gln Arg Ser Val Gln Val
             260                 265                 270        
 Leu Arg Ala Ile Val Val Met Tyr Val Ile Cys Trp Leu Pro Tyr His
         275                 280                 285            
 Ala Arg Arg Leu Met Tyr Cys Tyr Val Pro Asp Asp Ala Trp Thr Asp
     290                 295                 300                
 Pro Leu Tyr Asn Phe Tyr His Tyr Phe Tyr Met Val Thr Asn Thr Leu
 305                 310                 315                 320
 Phe Tyr Val Ser Ser Ala Val Thr Pro Leu Leu Tyr Asn Ala Val Ser
                 325                 330                 335    
 Ser Ser Phe Arg Lys Leu Phe Leu Glu Ala Val Ser Ser Leu Cys Gly
             340                 345                 350        
 Glu His His Pro Met Lys Arg Leu Pro Pro Lys Pro Gln Ser Pro Thr
         355                 360                 365            
 Leu Met Asp Thr Ala Ser Gly Phe Gly Asp Pro Pro Glu Thr Arg Thr
     370                 375                 380                





      <210> 1297
      <211> 3215
      <212> PRT
      <213> Homo sapiens


      <400> 1297
 Met Ile Ala Ala Ala Phe Leu Val Leu Leu Arg Pro Tyr Ser Ile Gln
   1               5                  10                  15    
 Cys Ala Leu Phe Leu Leu Leu Leu Leu Leu Gly Thr Ile Ala Thr Ile
              20                  25                  30        
 Val Phe Phe Cys Cys Trp His Arg Lys Leu Gln Lys Gly Arg His Pro
          35                  40                  45            
 Met Lys Ser Val Phe Ser Gly Arg Ser Arg Ser Arg Asp Ala Val Leu
      50                  55                  60                
 Arg Ser His His Phe Arg Ser Glu Gly Phe Arg Ala Ser Pro Arg His
  65                  70                  75                  80
 Leu Arg Arg Arg Val Ala Ala Ala Ala Ala Ala Arg Leu Glu Glu Val
                  85                  90                  95    
 Lys Pro Val Val Glu Val His His Gln Ser Glu Gln Glu Thr Ser Val
             100                 105                 110        
 Arg Lys Arg Arg Ile Lys Lys Ser Ser Arg Val Gln Pro Glu Phe Tyr
         115                 120                 125            
 His Ser Val Gln Gly Ala Ser Ile Arg Arg Pro Ser Ser Gly Asn Ala
     130                 135                 140                
 Ser Tyr Arg Cys Ser Met Ser Ser Ser Ala Asp Phe Ser Asp Glu Glu
 145                 150                 155                 160
 Asp Phe Ser Gln Lys Ser Gly Ser Ala Ser Pro Ala Pro Gly Asp Thr
                 165                 170                 175    
 Leu Pro Trp Asn Leu Pro Lys His Glu Arg Ser Lys Arg Lys Ile Gln
             180                 185                 190        
 Gly Gly Ser Val Leu Asp Pro Ala Glu Arg Ala Val Leu Arg Ile Ala
         195                 200                 205            
 Asp Glu Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn
     210                 215                 220                
 Gln His Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp
 225                 230                 235                 240
 Leu Arg Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly
                 245                 250                 255    
 Asp Thr Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln
             260                 265                 270        
 Asn Val Gln Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu
         275                 280                 285            
 Val Asn Ile Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr
     290                 295                 300                
 Leu Gly Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile
 305                 310                 315                 320
 His Val Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu
                 325                 330                 335    
 Leu Trp Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu
             340                 345                 350        
 Asn Phe Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile
         355                 360                 365            
 His Lys Tyr Arg Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln
     370                 375                 380                
 Ser Asn Leu Ala Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile
 385                 390                 395                 400
 Gly Val Ile Arg Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro
                 405                 410                 415    
 Asp Glu Lys Ser Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe
             420                 425                 430        
 Pro Lys Val Pro Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu
         435                 440                 445            
 Val Lys Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp
     450                 455                 460                
 Ile Arg His His Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn
 465                 470                 475                 480
 Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu
                 485                 490                 495    
 Thr Glu Ile Pro Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu
             500                 505                 510        
 Tyr Lys Leu Leu Glu Lys Val Phe Cys Phe Leu Lys Ile Trp Ile Glu
         515                 520                 525            
 Phe Gly Arg Ile Lys Leu Leu Gln Gly Tyr His Pro Asn Asp Ile Glu
     530                 535                 540                
 Lys Glu Trp Gly Lys Leu Ile Ile Ala Met Leu Glu Arg Glu Lys Ala
 545                 550                 555                 560
 Leu Arg Pro Glu Val Glu Arg Leu Glu Met Leu Gln Gln Ile Ala Asn
                 565                 570                 575    
 Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu Ala
             580                 585                 590        
 Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val Gln
         595                 600                 605            
 Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu Asn
     610                 615                 620                
 Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly Lys
 625                 630                 635                 640
 Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg Asp
                 645                 650                 655    
 Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys Gly
             660                 665                 670        
 Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile Thr
         675                 680                 685            
 Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu Thr
     690                 695                 700                
 Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser Met
 705                 710                 715                 720
 Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser Val
                 725                 730                 735    
 Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn Phe
             740                 745                 750        
 Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met Gln
         755                 760                 765            
 Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu Thr
     770                 775                 780                
 Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp Val
 785                 790                 795                 800
 Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp Leu
                 805                 810                 815    
 Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg Ala
             820                 825                 830        
 Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu Ile
         835                 840                 845            
 Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His Arg
     850                 855                 860                
 Leu Glu Ser Gln Tyr Ala Lys Leu Leu Phe Ser Leu Leu Lys Asn Thr
 865                 870                 875                 880
 Ser Arg Asn Gln Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser
                 885                 890                 895    
 Arg Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu
             900                 905                 910        
 Val Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys
         915                 920                 925            
 Asp Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn
     930                 935                 940                
 Ile Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His
 945                 950                 955                 960
 Pro Ala Arg Leu Thr Ile Glu Val Lys Leu Glu Ser Val Met Val Leu
                 965                 970                 975    
 Val Glu Tyr Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile
             980                 985                 990        
 Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala
         995                1000                1005            
 Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg
    1010                1015                1020                
 Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser
1025                1030                1035                1040
 Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys
                1045                1050                1055    
 Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys
            1060                1065                1070        
 Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu
        1075                1080                1085            
 Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu
    1090                1095                1100                
 Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His
1105                1110                1115                1120
 Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val
                1125                1130                1135    
 Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp
            1140                1145                1150        
 Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp
        1155                1160                1165            
 His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu
    1170                1175                1180                
 Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Val Ser
1185                1190                1195                1200
 Met Asn Leu Ile Lys Thr Met Leu Pro Gly Glu His Gln Gln Val Leu
                1205                1210                1215    
 Ser Asn Leu Gln Ser Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu
            1220                1225                1230        
 Ser Gln Val Phe Ser Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val
        1235                1240                1245            
 Asn Val Cys Lys Gln Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg
    1250                1255                1260                
 Glu Glu Gln Glu Glu Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg
1265                1270                1275                1280
 Asn Ile Arg Leu Arg Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln
                1285                1290                1295    
 Ile Arg Thr Pro Leu Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg
            1300                1305                1310        
 Ile Thr Glu Gln Glu Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp
        1315                1320                1325            
 Asp Leu Gly Thr Ile Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala
    1330                1335                1340                
 Ala Ala Ser Ser Ser Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val
1345                1350                1355                1360
 Leu Gln Asn Met Asn Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp
                1365                1370                1375    
 Lys Tyr Val Thr Ala Ile Ser Ile Tyr Lys Gly Tyr Cys Leu Ile Ser
            1380                1385                1390        
 Phe Leu Arg Leu Lys Thr Val Asn Leu Val Leu Lys Asn Thr Gln Ala
        1395                1400                1405            
 Ala Glu Ala Leu Val Lys Leu Tyr Glu Thr Lys Leu Cys Glu Glu Glu
    1410                1415                1420                
 Ala Val Ile Ala Asp Lys Asn Asn Ile Glu Asn Leu Ile Ser Thr Leu
1425                1430                1435                1440
 Lys Gln Trp Arg Ser Glu Val Asp Glu Lys Arg Gln Val Phe His Ala
                1445                1450                1455    
 Leu Glu Asp Glu Leu Gln Lys Ala Lys Ala Ile Ser Asp Glu Met Phe
            1460                1465                1470        
 Lys Thr Tyr Lys Glu Arg Asp Leu Asp Phe Asp Trp His Lys Glu Lys
        1475                1480                1485            
 Ala Asp Gln Leu Val Glu Arg Trp Gln Asn Val His Val Gln Ile Asp
    1490                1495                1500                
 Asn Arg Leu Arg Asp Leu Glu Gly Ile Gly Lys Ser Leu Lys Tyr Tyr
1505                1510                1515                1520
 Arg Asp Thr Tyr His Pro Leu Asp Asp Trp Ile Gln Gln Val Glu Thr
                1525                1530                1535    
 Thr Gln Arg Lys Ile Gln Glu Asn Gln Pro Glu Asn Ser Lys Thr Leu
            1540                1545                1550        
 Ala Thr Gln Leu Asn Gln Gln Lys Met Leu Val Ser Glu Ile Glu Met
        1555                1560                1565            
 Lys Gln Ser Lys Met Asp Glu Cys Gln Lys Tyr Ala Glu Gln Tyr Ser
    1570                1575                1580                
 Ala Thr Val Lys Asp Tyr Glu Leu Gln Thr Met Thr Tyr Arg Ala Met
1585                1590                1595                1600
 Val Asp Ser Gln Gln Lys Ser Pro Val Lys Arg Arg Arg Met Gln Ser
                1605                1610                1615    
 Ser Ala Asp Leu Ile Ile Gln Glu Phe Met Asp Leu Arg Thr Arg Tyr
            1620                1625                1630        
 Thr Ala Leu Val Thr Leu Met Thr Gln Tyr Ile Lys Phe Ala Gly Asp
        1635                1640                1645            
 Ser Leu Lys Arg Leu Glu Glu Glu Glu Val Ile Ile Asn Ser Glu His
    1650                1655                1660                
 Pro Val Asn Ile Lys Glu Leu Glu Ile Lys Arg Cys Lys Glu Thr Ser
1665                1670                1675                1680
 Glu His Gly Ala Tyr Ser Asp Leu Leu Gln Arg Gln Lys Ala Thr Val
                1685                1690                1695    
 Leu Glu Asn Ser Lys Leu Thr Gly Lys Ile Ser Glu Leu Glu Arg Met
            1700                1705                1710        
 Val Ala Glu Leu Lys Lys Gln Lys Ser Arg Val Glu Glu Glu Leu Pro
        1715                1720                1725            
 Lys Val Arg Glu Ala Ala Glu Asn Glu Leu Arg Lys Gln Gln Arg Asn
    1730                1735                1740                
 Val Glu Asp Ile Ser Leu Gln Lys Ile Arg Ala Glu Ser Glu Ala Lys
1745                1750                1755                1760
 Gln Tyr Arg Arg Glu Leu Glu Thr Ile Val Arg Glu Lys Glu Ala Ala
                1765                1770                1775    
 Glu Arg Glu Leu Glu Arg Val Arg Gln Leu Thr Ile Glu Ala Glu Ala
            1780                1785                1790        
 Lys Arg Ala Ala Val Glu Glu Asn Leu Leu Asn Phe Arg Asn Gln Leu
        1795                1800                1805            
 Glu Glu Asn Thr Phe Thr Arg Arg Thr Leu Glu Asp His Leu Lys Arg
    1810                1815                1820                
 Lys Asp Leu Ser Leu Asn Asp Leu Glu Gln Gln Lys Asn Lys Leu Met
1825                1830                1835                1840
 Glu Glu Leu Arg Arg Lys Arg Asp Asn Glu Glu Glu Leu Leu Lys Leu
                1845                1850                1855    
 Ile Lys Gln Met Glu Lys Asp Leu Ala Phe Gln Lys Gln Val Ala Glu
            1860                1865                1870        
 Lys Gln Leu Lys Glu Lys Gln Lys Ile Glu Leu Glu Ala Arg Arg Lys
        1875                1880                1885            
 Ile Thr Glu Ile Gln Tyr Thr Cys Arg Glu Asn Ala Leu Pro Val Cys
    1890                1895                1900                
 Pro Ile Thr Gln Ala Thr Ser Cys Arg Ala Val Thr Gly Leu Gln Gln
1905                1910                1915                1920
 Glu His Asp Lys Gln Lys Ala Glu Glu Leu Lys Gln Gln Val Asp Glu
                1925                1930                1935    
 Leu Thr Ala Ala Asn Arg Lys Ala Glu Gln Asp Met Arg Glu Leu Thr
            1940                1945                1950        
 Tyr Glu Leu Asn Ala Leu Gln Leu Glu Lys Thr Ser Ser Glu Glu Lys
        1955                1960                1965            
 Ala Arg Leu Leu Lys Asp Lys Leu Asp Glu Thr Asn Asn Thr Leu Arg
    1970                1975                1980                
 Cys Leu Lys Leu Glu Leu Glu Arg Lys Asp Gln Ala Glu Lys Gly Tyr
1985                1990                1995                2000
 Ser Gln Gln Leu Arg Glu Leu Gly Arg Gln Leu Asn Gln Thr Thr Gly
                2005                2010                2015    
 Lys Ala Glu Glu Ala Met Gln Glu Ala Ser Asp Leu Lys Lys Ile Lys
            2020                2025                2030        
 Arg Asn Tyr Gln Leu Glu Leu Glu Ser Leu Asn His Glu Lys Gly Lys
        2035                2040                2045            
 Leu Gln Arg Glu Val Asp Arg Ile Thr Arg Ala His Ala Val Ala Glu
    2050                2055                2060                
 Lys Asn Ile Gln His Leu Asn Ser Gln Ile His Ser Phe Arg Asp Glu
2065                2070                2075                2080
 Lys Glu Leu Glu Arg Leu Gln Ile Cys Gln Arg Lys Ser Asp His Leu
                2085                2090                2095    
 Lys Glu Gln Phe Glu Lys Ser His Glu Gln Leu Leu Gln Asn Ile Lys
            2100                2105                2110        
 Ala Glu Lys Glu Asn Asn Asp Lys Ile Gln Arg Leu Asn Glu Glu Leu
        2115                2120                2125            
 Glu Lys Ser Asn Glu Cys Ala Glu Met Leu Lys Gln Lys Val Glu Glu
    2130                2135                2140                
 Leu Thr Arg Gln Asn Asn Glu Thr Lys Leu Met Met Gln Arg Ile Gln
2145                2150                2155                2160
 Ala Glu Ser Glu Asn Ile Val Leu Glu Lys Gln Thr Ile Gln Gln Arg
                2165                2170                2175    
 Cys Glu Ala Leu Lys Ile Gln Ala Asp Gly Phe Lys Asp Gln Leu Arg
            2180                2185                2190        
 Ser Thr Asn Glu His Leu His Lys Gln Thr Lys Thr Glu Gln Asp Phe
        2195                2200                2205            
 Gln Arg Lys Ile Lys Cys Leu Glu Glu Asp Leu Ala Lys Ser Gln Asn
    2210                2215                2220                
 Leu Val Ser Glu Phe Lys Gln Lys Cys Asp Gln Gln Asn Ile Ile Ile
2225                2230                2235                2240
 Gln Asn Thr Lys Lys Glu Val Arg Asn Leu Asn Ala Glu Leu Asn Ala
                2245                2250                2255    
 Ser Lys Glu Glu Lys Arg Arg Gly Glu Gln Lys Val Gln Leu Gln Gln
            2260                2265                2270        
 Ala Gln Val Gln Glu Leu Asn Asn Arg Leu Lys Lys Val Gln Asp Glu
        2275                2280                2285            
 Leu His Leu Lys Thr Ile Glu Glu Gln Met Thr His Arg Lys Met Val
    2290                2295                2300                
 Leu Phe Gln Glu Glu Ser Gly Lys Phe Lys Gln Ser Ala Glu Glu Phe
2305                2310                2315                2320
 Arg Lys Lys Met Glu Lys Leu Met Glu Ser Lys Val Ile Thr Glu Asn
                2325                2330                2335    
 Asp Ile Ser Gly Ile Arg Leu Asp Phe Val Ser Leu Gln Gln Glu Asn
            2340                2345                2350        
 Ser Arg Ala Gln Glu Asn Ala Lys Leu Cys Glu Thr Asn Ile Lys Glu
        2355                2360                2365            
 Leu Glu Arg Gln Leu Gln Gln Tyr Arg Glu Gln Met Gln Gln Gly Gln
    2370                2375                2380                
 His Met Glu Ala Asn His Tyr Gln Lys Cys Gln Lys Leu Glu Asp Glu
2385                2390                2395                2400
 Leu Ile Ala Gln Lys Arg Glu Val Glu Asn Leu Lys Gln Lys Met Asp
                2405                2410                2415    
 Gln Gln Ile Lys Glu His Glu His Gln Leu Val Leu Leu Gln Cys Glu
            2420                2425                2430        
 Ile Gln Lys Lys Ser Thr Ala Lys Asp Cys Thr Phe Lys Pro Asp Phe
        2435                2440                2445            
 Glu Met Thr Val Lys Glu Cys Gln His Ser Gly Glu Leu Ser Ser Arg
    2450                2455                2460                
 Asn Thr Gly His Leu His Pro Thr Pro Arg Ser Pro Leu Leu Arg Trp
2465                2470                2475                2480
 Thr Gln Glu Pro Gln Pro Leu Glu Glu Lys Trp Gln His Arg Val Val
                2485                2490                2495    
 Glu Gln Ile Pro Lys Glu Val Gln Phe Gln Pro Pro Gly Ala Pro Leu
            2500                2505                2510        
 Glu Lys Glu Lys Ser Gln Gln Cys Tyr Ser Glu Tyr Phe Ser Gln Thr
        2515                2520                2525            
 Ser Thr Glu Leu Gln Ile Thr Phe Asp Glu Thr Asn Pro Ile Thr Arg
    2530                2535                2540                
 Leu Ser Glu Ile Glu Lys Ile Arg Asp Gln Ala Leu Asn Asn Ser Arg
2545                2550                2555                2560
 Pro Pro Val Arg Tyr Gln Asp Asn Ala Cys Glu Met Glu Leu Val Lys
                2565                2570                2575    
 Val Leu Thr Pro Leu Glu Ile Ala Lys Asn Lys Gln Tyr Asp Met His
            2580                2585                2590        
 Thr Glu Val Thr Thr Leu Lys Gln Glu Lys Asn Pro Val Pro Ser Ala
        2595                2600                2605            
 Glu Glu Trp Met Leu Glu Gly Cys Arg Ala Ser Gly Gly Leu Lys Lys
    2610                2615                2620                
 Gly Asp Phe Leu Lys Lys Gly Leu Glu Pro Glu Thr Phe Gln Asn Phe
2625                2630                2635                2640
 Asp Gly Asp His Ala Cys Ser Val Arg Asp Asp Glu Phe Lys Phe Gln
                2645                2650                2655    
 Gly Leu Arg His Thr Val Thr Ala Arg Gln Leu Val Glu Ala Lys Leu
            2660                2665                2670        
 Leu Asp Met Arg Thr Ile Glu Gln Leu Arg Leu Gly Leu Lys Thr Val
        2675                2680                2685            
 Glu Glu Val Gln Lys Thr Leu Asn Lys Phe Leu Thr Lys Ala Thr Ser
    2690                2695                2700                
 Ile Ala Gly Leu Tyr Leu Glu Ser Thr Lys Glu Lys Ile Ser Phe Ala
2705                2710                2715                2720
 Ser Ala Ala Glu Arg Ile Ile Ile Asp Lys Met Val Ala Leu Ala Phe
                2725                2730                2735    
 Leu Glu Ala Gln Ala Ala Thr Gly Phe Ile Ile Asp Pro Ile Ser Gly
            2740                2745                2750        
 Gln Thr Tyr Ser Val Glu Asp Ala Val Leu Lys Gly Val Val Asp Pro
        2755                2760                2765            
 Glu Phe Arg Ile Arg Leu Leu Glu Ala Glu Lys Ala Ala Val Gly Tyr
    2770                2775                2780                
 Ser Tyr Ser Ser Lys Thr Leu Ser Val Phe Gln Ala Met Glu Asn Arg
2785                2790                2795                2800
 Met Leu Asp Arg Gln Lys Gly Lys His Ile Leu Glu Ala Gln Ile Ala
                2805                2810                2815    
 Ser Gly Gly Val Ile Asp Pro Val Arg Gly Ile Arg Val Pro Pro Glu
            2820                2825                2830        
 Ile Ala Leu Gln Gln Gly Leu Leu Asn Asn Ala Ile Leu Gln Phe Leu
        2835                2840                2845            
 His Glu Pro Ser Ser Asn Thr Arg Val Phe Pro Asn Pro Asn Asn Lys
    2850                2855                2860                
 Gln Ala Leu Tyr Tyr Ser Glu Leu Leu Arg Met Cys Val Phe Asp Val
2865                2870                2875                2880
 Glu Ser Gln Cys Phe Leu Phe Pro Phe Gly Glu Arg Asn Ile Ser Asn
                2885                2890                2895    
 Leu Asn Val Lys Lys Thr His Arg Ile Ser Val Val Asp Thr Lys Thr
            2900                2905                2910        
 Gly Ser Glu Leu Thr Val Tyr Glu Ala Phe Gln Arg Asn Leu Ile Glu
        2915                2920                2925            
 Lys Ser Ile Tyr Leu Glu Leu Ser Gly Gln Gln Tyr Gln Trp Lys Glu
    2930                2935                2940                
 Ala Met Phe Phe Glu Ser Tyr Gly His Ser Ser His Met Leu Thr Asp
2945                2950                2955                2960
 Thr Lys Thr Gly Leu His Phe Asn Ile Asn Glu Ala Ile Glu Gln Gly
                2965                2970                2975    
 Thr Ile Asp Lys Ala Leu Val Lys Lys Tyr Gln Glu Gly Leu Ile Thr
            2980                2985                2990        
 Leu Thr Glu Leu Ala Asp Ser Leu Leu Ser Arg Leu Val Pro Lys Lys
        2995                3000                3005            
 Asp Leu His Ser Pro Val Ala Gly Tyr Trp Leu Thr Ala Ser Gly Glu
    3010                3015                3020                
 Arg Ile Ser Val Leu Lys Ala Ser Arg Arg Asn Leu Val Asp Arg Ile
3025                3030                3035                3040
 Thr Ala Leu Arg Cys Leu Glu Ala Gln Val Ser Thr Gly Gly Ile Ile
                3045                3050                3055    
 Asp Pro Leu Thr Gly Lys Lys Tyr Arg Val Ala Glu Ala Leu His Arg
            3060                3065                3070        
 Gly Leu Val Asp Glu Gly Phe Ala Gln Gln Leu Arg Gln Cys Glu Leu
        3075                3080                3085            
 Val Ile Thr Gly Ile Gly His Pro Ile Thr Asn Lys Met Met Ser Val
    3090                3095                3100                
 Val Glu Ala Val Asn Ala Asn Ile Ile Asn Lys Glu Met Gly Ile Arg
3105                3110                3115                3120
 Cys Leu Glu Phe Gln Tyr Leu Thr Gly Gly Leu Ile Glu Pro Gln Val
                3125                3130                3135    
 His Ser Arg Leu Ser Ile Glu Glu Ala Leu Gln Val Gly Ile Ile Asp
            3140                3145                3150        
 Val Leu Ile Ala Thr Lys Leu Lys Asp Gln Lys Ser Tyr Val Arg Asn
        3155                3160                3165            
 Ile Ile Cys Pro Gln Thr Lys Arg Lys Leu Thr Tyr Lys Glu Ala Leu
    3170                3175                3180                
 Glu Lys Ala Asp Phe Asp Phe His Thr Gly Leu Lys Leu Leu Glu Val
3185                3190                3195                3200
 Ser Glu Pro Leu Met Thr Gly Ile Ser Ser Leu Tyr Tyr Ser Ser
                3205                3210                3215



      <210> 1298
      <211> 3227
      <212> PRT
      <213> Homo sapiens


      <400> 1298
 Met Ile Ala Ala Ala Phe Leu Val Leu Leu Arg Pro Tyr Ser Ile Gln
   1               5                  10                  15    
 Cys Ala Leu Phe Leu Leu Leu Leu Leu Leu Gly Thr Ile Ala Thr Ile
              20                  25                  30        
 Val Phe Phe Cys Cys Trp His Arg Lys Leu Gln Lys Gly Arg His Pro
          35                  40                  45            
 Met Lys Ser Val Phe Ser Gly Arg Ser Arg Ser Arg Asp Ala Val Leu
      50                  55                  60                
 Arg Ser His His Phe Arg Ser Glu Gly Phe Arg Ala Ser Pro Arg His
  65                  70                  75                  80
 Leu Arg Arg Arg Val Ala Ala Ala Ala Ala Ala Arg Leu Glu Glu Val
                  85                  90                  95    
 Lys Pro Val Val Glu Val His His Gln Ser Glu Gln Glu Thr Ser Val
             100                 105                 110        
 Arg Lys Arg Arg Ile Lys Lys Ser Ser Arg Val Gln Pro Glu Phe Tyr
         115                 120                 125            
 His Ser Val Gln Gly Ala Ser Ile Arg Arg Pro Ser Ser Gly Asn Ala
     130                 135                 140                
 Ser Tyr Arg Cys Ser Met Ser Ser Ser Ala Asp Phe Ser Asp Glu Glu
 145                 150                 155                 160
 Asp Phe Ser Gln Lys Ser Gly Ser Ala Ser Pro Ala Pro Gly Asp Thr
                 165                 170                 175    
 Leu Pro Trp Asn Leu Pro Lys His Glu Arg Ser Lys Arg Lys Ile Gln
             180                 185                 190        
 Gly Gly Ser Val Leu Asp Pro Ala Glu Arg Ala Val Leu Arg Ile Ala
         195                 200                 205            
 Asp Glu Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn
     210                 215                 220                
 Gln His Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp
 225                 230                 235                 240
 Leu Arg Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly
                 245                 250                 255    
 Asp Thr Leu Pro Arg Glu Arg Asp Phe Leu Lys Thr Leu Arg Leu Pro
             260                 265                 270        
 Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln Asn Val Gln Ile
         275                 280                 285            
 Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu Val Asn Ile Arg
     290                 295                 300                
 Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile
 305                 310                 315                 320
 Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile His Val Thr Gly
                 325                 330                 335    
 Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu Leu Trp Thr Gln
             340                 345                 350        
 Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu Asn Phe Thr Thr
         355                 360                 365            
 Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile His Lys Tyr Arg
     370                 375                 380                
 Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln Ser Asn Leu Ala
 385                 390                 395                 400
 Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile Gly Val Ile Arg
                 405                 410                 415    
 Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro Asp Glu Lys Ser
             420                 425                 430        
 Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe Pro Lys Val Pro
         435                 440                 445            
 Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu Val Lys Trp Ile
     450                 455                 460                
 Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp Ile Arg His His
 465                 470                 475                 480
 Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn Pro Val Glu Leu
                 485                 490                 495    
 Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu Thr Glu Ile Pro
             500                 505                 510        
 Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu Tyr Lys Leu Leu
         515                 520                 525            
 Glu Lys Val Phe Cys Phe Leu Lys Ile Trp Ile Glu Phe Gly Arg Ile
     530                 535                 540                
 Lys Leu Leu Gln Gly Tyr His Pro Asn Asp Ile Glu Lys Glu Trp Gly
 545                 550                 555                 560
 Lys Leu Ile Ile Ala Met Leu Glu Arg Glu Lys Ala Leu Arg Pro Glu
                 565                 570                 575    
 Val Glu Arg Leu Glu Met Leu Gln Gln Ile Ala Asn Arg Val Gln Arg
             580                 585                 590        
 Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly Asn Ala Leu
         595                 600                 605            
 Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val Gln Phe Gln Asn Glu
     610                 615                 620                
 Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu Leu Arg Gln
 625                 630                 635                 640
 His Val Ile Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr Tyr Gln Ala
                 645                 650                 655    
 Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg Asp Glu Ile Met Ala
             660                 665                 670        
 Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg Ile Leu Thr
         675                 680                 685            
 Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile Thr Gln Ser Leu Asn
     690                 695                 700                
 Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu Thr Ser Gly Leu Thr
 705                 710                 715                 720
 Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser Met Thr Ser Gly Leu
                 725                 730                 735    
 Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser Val Thr Pro Ala Tyr
             740                 745                 750        
 Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn Phe Ser Ser Gly Val
         755                 760                 765            
 Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met Gln Ile Arg Lys Pro
     770                 775                 780                
 Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu Thr Glu Glu Glu Ile
 785                 790                 795                 800
 Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp Val Asp Glu Met Gln
                 805                 810                 815    
 Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp Leu Pro Ser Val Glu
             820                 825                 830        
 Ser His Leu Glu Asn His Lys Asn Val His Arg Ala Ile Glu Glu Phe
         835                 840                 845            
 Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu Ile Gln Met Thr Ala
     850                 855                 860                
 Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His Arg Leu Glu Ser Gln
 865                 870                 875                 880
 Tyr Ala Lys Leu Leu Phe Ser Leu Leu Lys Asn Thr Ser Arg Asn Gln
                 885                 890                 895    
 Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn
             900                 905                 910        
 Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp
         915                 920                 925            
 Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala
     930                 935                 940                
 Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val
 945                 950                 955                 960
 Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu
                 965                 970                 975    
 Thr Ile Glu Val Lys Leu Glu Ser Val Met Val Leu Val Glu Tyr Ala
             980                 985                 990        
 Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile Leu Gln Leu Cys
         995                1000                1005            
 Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala Tyr Phe Glu Phe
    1010                1015                1020                
 Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg Asn Leu Lys Asp
1025                1030                1035                1040
 Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser Ser Ile His Lys
                1045                1050                1055    
 Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys Glu Glu Leu Leu
            1060                1065                1070        
 Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys Ala Lys Thr Ile
        1075                1080                1085            
 Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu Lys Thr Ser Ile
    1090                1095                1100                
 Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu Ile Thr Ile Tyr
1105                1110                1115                1120
 Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His Arg Ala Lys Trp
                1125                1130                1135    
 Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val Pro Ser Val Cys
            1140                1145                1150        
 Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp Leu Ala Asn Arg
        1155                1160                1165            
 Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp His Glu Ser His
    1170                1175                1180                
 Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu Ile Asn Glu Ile
1185                1190                1195                1200
 Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Val Ser Met Asn Leu Ile
                1205                1210                1215    
 Lys Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln
            1220                1225                1230        
 Ser Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe
        1235                1240                1245            
 Ser Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys
    1250                1255                1260                
 Gln Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu
1265                1270                1275                1280
 Glu Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu
                1285                1290                1295    
 Arg Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro
            1300                1305                1310        
 Leu Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln
        1315                1320                1325            
 Glu Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr
    1330                1335                1340                
 Ile Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser
1345                1350                1355                1360
 Ser Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met
                1365                1370                1375    
 Asn Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Tyr Val Thr
            1380                1385                1390        
 Ala Ile Ser Ile Tyr Lys Gly Tyr Cys Leu Ile Ser Phe Leu Arg Leu
        1395                1400                1405            
 Lys Thr Val Asn Leu Val Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu
    1410                1415                1420                
 Val Lys Leu Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala
1425                1430                1435                1440
 Asp Lys Asn Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg
                1445                1450                1455    
 Ser Glu Val Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu
            1460                1465                1470        
 Leu Gln Lys Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys
        1475                1480                1485            
 Glu Arg Asp Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu
    1490                1495                1500                
 Val Glu Arg Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg
1505                1510                1515                1520
 Asp Leu Glu Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr
                1525                1530                1535    
 His Pro Leu Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys
            1540                1545                1550        
 Ile Gln Glu Asn Gln Pro Glu Asn Ser Lys Thr Leu Ala Thr Gln Leu
        1555                1560                1565            
 Asn Gln Gln Lys Met Leu Val Ser Glu Ile Glu Met Lys Gln Ser Lys
    1570                1575                1580                
 Met Asp Glu Cys Gln Lys Tyr Ala Glu Gln Tyr Ser Ala Thr Val Lys
1585                1590                1595                1600
 Asp Tyr Glu Leu Gln Thr Met Thr Tyr Arg Ala Met Val Asp Ser Gln
                1605                1610                1615    
 Gln Lys Ser Pro Val Lys Arg Arg Arg Met Gln Ser Ser Ala Asp Leu
            1620                1625                1630        
 Ile Ile Gln Glu Phe Met Asp Leu Arg Thr Arg Tyr Thr Ala Leu Val
        1635                1640                1645            
 Thr Leu Met Thr Gln Tyr Ile Lys Phe Ala Gly Asp Ser Leu Lys Arg
    1650                1655                1660                
 Leu Glu Glu Glu Glu Val Ile Ile Asn Ser Glu His Pro Val Asn Ile
1665                1670                1675                1680
 Lys Glu Leu Glu Ile Lys Arg Cys Lys Glu Thr Ser Glu His Gly Ala
                1685                1690                1695    
 Tyr Ser Asp Leu Leu Gln Arg Gln Lys Ala Thr Val Leu Glu Asn Ser
            1700                1705                1710        
 Lys Leu Thr Gly Lys Ile Ser Glu Leu Glu Arg Met Val Ala Glu Leu
        1715                1720                1725            
 Lys Lys Gln Lys Ser Arg Val Glu Glu Glu Leu Pro Lys Val Arg Glu
    1730                1735                1740                
 Ala Ala Glu Asn Glu Leu Arg Lys Gln Gln Arg Asn Val Glu Asp Ile
1745                1750                1755                1760
 Ser Leu Gln Lys Ile Arg Ala Glu Ser Glu Ala Lys Gln Tyr Arg Arg
                1765                1770                1775    
 Glu Leu Glu Thr Ile Val Arg Glu Lys Glu Ala Ala Glu Arg Glu Leu
            1780                1785                1790        
 Glu Arg Val Arg Gln Leu Thr Ile Glu Ala Glu Ala Lys Arg Ala Ala
        1795                1800                1805            
 Val Glu Glu Asn Leu Leu Asn Phe Arg Asn Gln Leu Glu Glu Asn Thr
    1810                1815                1820                
 Phe Thr Arg Arg Thr Leu Glu Asp His Leu Lys Arg Lys Asp Leu Ser
1825                1830                1835                1840
 Leu Asn Asp Leu Glu Gln Gln Lys Asn Lys Leu Met Glu Glu Leu Arg
                1845                1850                1855    
 Arg Lys Arg Asp Asn Glu Glu Glu Leu Leu Lys Leu Ile Lys Gln Met
            1860                1865                1870        
 Glu Lys Asp Leu Ala Phe Gln Lys Gln Val Ala Glu Lys Gln Leu Lys
        1875                1880                1885            
 Glu Lys Gln Lys Ile Glu Leu Glu Ala Arg Arg Lys Ile Thr Glu Ile
    1890                1895                1900                
 Gln Tyr Thr Cys Arg Glu Asn Ala Leu Pro Val Cys Pro Ile Thr Gln
1905                1910                1915                1920
 Ala Thr Ser Cys Arg Ala Val Thr Gly Leu Gln Gln Glu His Asp Lys
                1925                1930                1935    
 Gln Lys Ala Glu Glu Leu Lys Gln Gln Val Asp Glu Leu Thr Ala Ala
            1940                1945                1950        
 Asn Arg Lys Ala Glu Gln Asp Met Arg Glu Leu Thr Tyr Glu Leu Asn
        1955                1960                1965            
 Ala Leu Gln Leu Glu Lys Thr Ser Ser Glu Glu Lys Ala Arg Leu Leu
    1970                1975                1980                
 Lys Asp Lys Leu Asp Glu Thr Asn Asn Thr Leu Arg Cys Leu Lys Leu
1985                1990                1995                2000
 Glu Leu Glu Arg Lys Asp Gln Ala Glu Lys Gly Tyr Ser Gln Gln Leu
                2005                2010                2015    
 Arg Glu Leu Gly Arg Gln Leu Asn Gln Thr Thr Gly Lys Ala Glu Glu
            2020                2025                2030        
 Ala Met Gln Glu Ala Ser Asp Leu Lys Lys Ile Lys Arg Asn Tyr Gln
        2035                2040                2045            
 Leu Glu Leu Glu Ser Leu Asn His Glu Lys Gly Lys Leu Gln Arg Glu
    2050                2055                2060                
 Val Asp Arg Ile Thr Arg Ala His Ala Val Ala Glu Lys Asn Ile Gln
2065                2070                2075                2080
 His Leu Asn Ser Gln Ile His Ser Phe Arg Asp Glu Lys Glu Leu Glu
                2085                2090                2095    
 Arg Leu Gln Ile Cys Gln Arg Lys Ser Asp His Leu Lys Glu Gln Phe
            2100                2105                2110        
 Glu Lys Ser His Glu Gln Leu Leu Gln Asn Ile Lys Ala Glu Lys Glu
        2115                2120                2125            
 Asn Asn Asp Lys Ile Gln Arg Leu Asn Glu Glu Leu Glu Lys Ser Asn
    2130                2135                2140                
 Glu Cys Ala Glu Met Leu Lys Gln Lys Val Glu Glu Leu Thr Arg Gln
2145                2150                2155                2160
 Asn Asn Glu Thr Lys Leu Met Met Gln Arg Ile Gln Ala Glu Ser Glu
                2165                2170                2175    
 Asn Ile Val Leu Glu Lys Gln Thr Ile Gln Gln Arg Cys Glu Ala Leu
            2180                2185                2190        
 Lys Ile Gln Ala Asp Gly Phe Lys Asp Gln Leu Arg Ser Thr Asn Glu
        2195                2200                2205            
 His Leu His Lys Gln Thr Lys Thr Glu Gln Asp Phe Gln Arg Lys Ile
    2210                2215                2220                
 Lys Cys Leu Glu Glu Asp Leu Ala Lys Ser Gln Asn Leu Val Ser Glu
2225                2230                2235                2240
 Phe Lys Gln Lys Cys Asp Gln Gln Asn Ile Ile Ile Gln Asn Thr Lys
                2245                2250                2255    
 Lys Glu Val Arg Asn Leu Asn Ala Glu Leu Asn Ala Ser Lys Glu Glu
            2260                2265                2270        
 Lys Arg Arg Gly Glu Gln Lys Val Gln Leu Gln Gln Ala Gln Val Gln
        2275                2280                2285            
 Glu Leu Asn Asn Arg Leu Lys Lys Val Gln Asp Glu Leu His Leu Lys
    2290                2295                2300                
 Thr Ile Glu Glu Gln Met Thr His Arg Lys Met Val Leu Phe Gln Glu
2305                2310                2315                2320
 Glu Ser Gly Lys Phe Lys Gln Ser Ala Glu Glu Phe Arg Lys Lys Met
                2325                2330                2335    
 Glu Lys Leu Met Glu Ser Lys Val Ile Thr Glu Asn Asp Ile Ser Gly
            2340                2345                2350        
 Ile Arg Leu Asp Phe Val Ser Leu Gln Gln Glu Asn Ser Arg Ala Gln
        2355                2360                2365            
 Glu Asn Ala Lys Leu Cys Glu Thr Asn Ile Lys Glu Leu Glu Arg Gln
    2370                2375                2380                
 Leu Gln Gln Tyr Arg Glu Gln Met Gln Gln Gly Gln His Met Glu Ala
2385                2390                2395                2400
 Asn His Tyr Gln Lys Cys Gln Lys Leu Glu Asp Glu Leu Ile Ala Gln
                2405                2410                2415    
 Lys Arg Glu Val Glu Asn Leu Lys Gln Lys Met Asp Gln Gln Ile Lys
            2420                2425                2430        
 Glu His Glu His Gln Leu Val Leu Leu Gln Cys Glu Ile Gln Lys Lys
        2435                2440                2445            
 Ser Thr Ala Lys Asp Cys Thr Phe Lys Pro Asp Phe Glu Met Thr Val
    2450                2455                2460                
 Lys Glu Cys Gln His Ser Gly Glu Leu Ser Ser Arg Asn Thr Gly His
2465                2470                2475                2480
 Leu His Pro Thr Pro Arg Ser Pro Leu Leu Arg Trp Thr Gln Glu Pro
                2485                2490                2495    
 Gln Pro Leu Glu Glu Lys Trp Gln His Arg Val Val Glu Gln Ile Pro
            2500                2505                2510        
 Lys Glu Val Gln Phe Gln Pro Pro Gly Ala Pro Leu Glu Lys Glu Lys
        2515                2520                2525            
 Ser Gln Gln Cys Tyr Ser Glu Tyr Phe Ser Gln Thr Ser Thr Glu Leu
    2530                2535                2540                
 Gln Ile Thr Phe Asp Glu Thr Asn Pro Ile Thr Arg Leu Ser Glu Ile
2545                2550                2555                2560
 Glu Lys Ile Arg Asp Gln Ala Leu Asn Asn Ser Arg Pro Pro Val Arg
                2565                2570                2575    
 Tyr Gln Asp Asn Ala Cys Glu Met Glu Leu Val Lys Val Leu Thr Pro
            2580                2585                2590        
 Leu Glu Ile Ala Lys Asn Lys Gln Tyr Asp Met His Thr Glu Val Thr
        2595                2600                2605            
 Thr Leu Lys Gln Glu Lys Asn Pro Val Pro Ser Ala Glu Glu Trp Met
    2610                2615                2620                
 Leu Glu Gly Cys Arg Ala Ser Gly Gly Leu Lys Lys Gly Asp Phe Leu
2625                2630                2635                2640
 Lys Lys Gly Leu Glu Pro Glu Thr Phe Gln Asn Phe Asp Gly Asp His
                2645                2650                2655    
 Ala Cys Ser Val Arg Asp Asp Glu Phe Lys Phe Gln Gly Leu Arg His
            2660                2665                2670        
 Thr Val Thr Ala Arg Gln Leu Val Glu Ala Lys Leu Leu Asp Met Arg
        2675                2680                2685            
 Thr Ile Glu Gln Leu Arg Leu Gly Leu Lys Thr Val Glu Glu Val Gln
    2690                2695                2700                
 Lys Thr Leu Asn Lys Phe Leu Thr Lys Ala Thr Ser Ile Ala Gly Leu
2705                2710                2715                2720
 Tyr Leu Glu Ser Thr Lys Glu Lys Ile Ser Phe Ala Ser Ala Ala Glu
                2725                2730                2735    
 Arg Ile Ile Ile Asp Lys Met Val Ala Leu Ala Phe Leu Glu Ala Gln
            2740                2745                2750        
 Ala Ala Thr Gly Phe Ile Ile Asp Pro Ile Ser Gly Gln Thr Tyr Ser
        2755                2760                2765            
 Val Glu Asp Ala Val Leu Lys Gly Val Val Asp Pro Glu Phe Arg Ile
    2770                2775                2780                
 Arg Leu Leu Glu Ala Glu Lys Ala Ala Val Gly Tyr Ser Tyr Ser Ser
2785                2790                2795                2800
 Lys Thr Leu Ser Val Phe Gln Ala Met Glu Asn Arg Met Leu Asp Arg
                2805                2810                2815    
 Gln Lys Gly Lys His Ile Leu Glu Ala Gln Ile Ala Ser Gly Gly Val
            2820                2825                2830        
 Ile Asp Pro Val Arg Gly Ile Arg Val Pro Pro Glu Ile Ala Leu Gln
        2835                2840                2845            
 Gln Gly Leu Leu Asn Asn Ala Ile Leu Gln Phe Leu His Glu Pro Ser
    2850                2855                2860                
 Ser Asn Thr Arg Val Phe Pro Asn Pro Asn Asn Lys Gln Ala Leu Tyr
2865                2870                2875                2880
 Tyr Ser Glu Leu Leu Arg Met Cys Val Phe Asp Val Glu Ser Gln Cys
                2885                2890                2895    
 Phe Leu Phe Pro Phe Gly Glu Arg Asn Ile Ser Asn Leu Asn Val Lys
            2900                2905                2910        
 Lys Thr His Arg Ile Ser Val Val Asp Thr Lys Thr Gly Ser Glu Leu
        2915                2920                2925            
 Thr Val Tyr Glu Ala Phe Gln Arg Asn Leu Ile Glu Lys Ser Ile Tyr
    2930                2935                2940                
 Leu Glu Leu Ser Gly Gln Gln Tyr Gln Trp Lys Glu Ala Met Phe Phe
2945                2950                2955                2960
 Glu Ser Tyr Gly His Ser Ser His Met Leu Thr Asp Thr Lys Thr Gly
                2965                2970                2975    
 Leu His Phe Asn Ile Asn Glu Ala Ile Glu Gln Gly Thr Ile Asp Lys
            2980                2985                2990        
 Ala Leu Val Lys Lys Tyr Gln Glu Gly Leu Ile Thr Leu Thr Glu Leu
        2995                3000                3005            
 Ala Asp Ser Leu Leu Ser Arg Leu Val Pro Lys Lys Asp Leu His Ser
    3010                3015                3020                
 Pro Val Ala Gly Tyr Trp Leu Thr Ala Ser Gly Glu Arg Ile Ser Val
3025                3030                3035                3040
 Leu Lys Ala Ser Arg Arg Asn Leu Val Asp Arg Ile Thr Ala Leu Arg
                3045                3050                3055    
 Cys Leu Glu Ala Gln Val Ser Thr Gly Gly Ile Ile Asp Pro Leu Thr
            3060                3065                3070        
 Gly Lys Lys Tyr Arg Val Ala Glu Ala Leu His Arg Gly Leu Val Asp
        3075                3080                3085            
 Glu Gly Phe Ala Gln Gln Leu Arg Gln Cys Glu Leu Val Ile Thr Gly
    3090                3095                3100                
 Ile Gly His Pro Ile Thr Asn Lys Met Met Ser Val Val Glu Ala Val
3105                3110                3115                3120
 Asn Ala Asn Ile Ile Asn Lys Glu Met Gly Ile Arg Cys Leu Glu Phe
                3125                3130                3135    
 Gln Tyr Leu Thr Gly Gly Leu Ile Glu Pro Gln Val His Ser Arg Leu
            3140                3145                3150        
 Ser Ile Glu Glu Ala Leu Gln Val Gly Ile Ile Asp Val Leu Ile Ala
        3155                3160                3165            
 Thr Lys Leu Lys Asp Gln Lys Ser Tyr Val Arg Asn Ile Ile Cys Pro
    3170                3175                3180                
 Gln Thr Lys Arg Lys Leu Thr Tyr Lys Glu Ala Leu Glu Lys Ala Asp
3185                3190                3195                3200
 Phe Asp Phe His Thr Gly Leu Lys Leu Leu Glu Val Ser Glu Pro Leu
                3205                3210                3215    
 Met Thr Gly Ile Ser Ser Leu Tyr Tyr Ser Ser
            3220                3225        



      <210> 1299
      <211> 295
      <212> PRT
      <213> Homo sapiens


      <400> 1299
 Met Glu Ser Thr Pro Glu Leu Leu Leu Ile Ser Ser Leu Glu Asp Thr
   1               5                  10                  15    
 Asn Glu Thr Arg Asn Ile Gln Ser Arg Cys Phe Arg Lys Arg His Lys
              20                  25                  30        
 Ser Asp Asn Glu Thr Asn Leu Gln Gln Gln Val Val Trp Gly Asn Arg
          35                  40                  45            
 Asn Arg Asn Leu Ser Gly Gly Val Leu Met Gly Phe Met Leu Asn Arg
      50                  55                  60                
 Ile Asn Gln Glu Ala Thr Pro Gly Asp Ile Val Glu Lys Leu Gly Ala
  65                  70                  75                  80
 Asp Ala Lys Ile Leu Ser Asn Val Ile Ser Lys Ser Thr Arg Pro Asn
                  85                  90                  95    
 Thr Leu Asp Ile Gly Lys Pro Pro Leu Arg Ser Lys Arg Asp Ser Leu
             100                 105                 110        
 Glu Lys Glu Ser Ser Asp Asp Asp Thr Pro Phe Asp Gly Ser Asn Tyr
         115                 120                 125            
 Leu Ala Asp Lys Val Asp Ser Pro Val Ile Phe Asp Leu Glu Asp Leu
     130                 135                 140                
 Asp Ser Glu Thr Asp Val Ser Lys Ala Gly Cys Val Ala Thr Gln Asn
 145                 150                 155                 160
 Pro Lys Arg Ile Gln Arg Met Asn Ser Ser Phe Ser Val Lys Pro Phe
                 165                 170                 175    
 Glu Lys Thr Asp Val Ala Thr Gly Phe Asp Pro Leu Ser Leu Leu Val
             180                 185                 190        
 Ala Glu Thr Glu Gln Gln Gln Lys Glu Glu Glu Glu Glu Asp Glu Asp
         195                 200                 205            
 Asp Ser Lys Ser Ile Ser Thr Pro Ser Ala Arg Arg Asp Leu Ala Glu
     210                 215                 220                
 Glu Ile Val Met Tyr Met Asn Asn Met Ser Ser Pro Leu Thr Ser Arg
 225                 230                 235                 240
 Thr Pro Ser Ile Asp Leu Gln Arg Ala Cys Asp Asp Lys Leu Asn Lys
                 245                 250                 255    
 Lys Ser Pro Pro Leu Val Lys Ala Cys Arg Arg Ser Ser Leu Pro Pro
             260                 265                 270        
 Asn Ser Pro Lys Pro Val Arg Leu Thr Lys Ser Lys Ser Tyr Thr Lys
         275                 280                 285            
 Ser Glu Glu Lys Pro Arg Asp
     290                 295



      <210> 1300
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 1300
 Met Gln Leu Leu Lys Ala Leu Trp Ala Leu Ala Gly Ala Ala Leu Cys
   1               5                  10                  15    
 Cys Phe Leu Val Leu Val Ile His Ala Gln Phe Leu Lys Glu Gly Gln
              20                  25                  30        
 Leu Ala Ala Gly Thr Cys Glu Ile Val Thr Leu Asp Arg Asp Ser Ser
          35                  40                  45            
 Gln Pro Arg Arg Thr Ile Ala Arg Gln Thr Ala Arg Cys Ala Cys Arg
      50                  55                  60                
 Lys Gly Gln Ile Ala Gly Thr Thr Arg Ala Arg Pro Ala Cys Val Asp
  65                  70                  75                  80
 Ala Arg Ile Ile Lys Thr Lys Gln Trp Cys Asp Met Leu Pro Cys Leu
                  85                  90                  95    
 Glu Gly Glu Gly Cys Asp Leu Leu Ile Asn Arg Ser Gly Trp Thr Cys
             100                 105                 110        
 Thr Gln Pro Gly Gly Arg Ile Lys Thr Thr Thr Val Ser
         115                 120                 125



      <210> 1301
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 1301
 Met Leu Lys His Pro Leu Leu Cys His Ser Ser Lys Pro Lys Leu Asp
   1               5                  10                  15    
 Thr Leu Gln Lys Pro Tyr Val His Lys Glu Lys Arg Ala Gln Arg Ile
              20                  25                  30        
 Pro Ile Pro Pro Pro Lys Lys Thr Arg Ala Gln Leu Leu Asp Asp Ile
          35                  40                  45            
 Phe Ile Arg Leu Arg Asp Pro Arg Asn Ile Thr Glu Ala Pro Leu Gly
      50                  55                  60                
 Ala Val Leu His Gln Trp Thr Glu Arg Arg Leu Val Asn His Lys Gln
  65                  70                  75                  80
 Tyr Leu Glu Ala Lys Arg Leu Leu Lys Glu Phe Gln Ala Arg Tyr Arg
                  85                  90                  95    
 Gln Leu Val Ser Gly Ser Leu Arg Thr Val Phe Gly Thr Thr Pro Leu
             100                 105                 110        
 Pro Met Ala Cys Pro Ala Leu Ser Glu Ser Gln Pro Lys Phe Gly His
         115                 120                 125            
 Phe Leu Glu Phe Met Asp Glu Phe Cys Gln Glu Pro Thr Ala Ser Asp
     130                 135                 140                
 Ser Gln Gly
 145        



      <210> 1302
      <211> 96
      <212> PRT
      <213> Homo sapiens


      <400> 1302
 Met Ser Leu Val Pro Leu Leu Ala Ser Phe Pro Ala Gly Ala Val Leu
   1               5                  10                  15    
 His Gln Trp Thr Glu Arg Arg Leu Val Asn Asn Lys Gln Tyr Leu Glu
              20                  25                  30        
 Ala Lys Arg Leu Leu Lys Glu Phe Gln Ala Arg Tyr Arg Gln Leu Val
          35                  40                  45            
 Ser Gly Ser Leu Arg Thr Val Phe Gly Thr Thr Pro Leu Pro Met Ala
      50                  55                  60                
 Cys Pro Ala Leu Ser Glu Ser Gln Pro Lys Phe Gly His Phe Leu Glu
  65                  70                  75                  80
 Phe Met Asp Glu Phe Cys Gln Glu Pro Thr Ala Ser Asp Ser Gln Gly
                  85                  90                  95    





      <210> 1303
      <211> 78
      <212> PRT
      <213> Homo sapiens


      <400> 1303
 Met Leu Ser Cys Arg Leu Gln Cys Ala Leu Ala Ala Leu Ser Ile Val
   1               5                  10                  15    
 Leu Ala Leu Gly Cys Val Thr Gly Ala Pro Ser Asp Pro Arg Leu Arg
              20                  25                  30        
 Gln Phe Leu Gln Lys Ser Leu Ala Ala Ala Ala Gly Lys Gln Val Arg
          35                  40                  45            
 Arg Leu Pro Arg Arg Leu Pro Asp Ser Pro Ala Leu Pro Lys Pro Cys
      50                  55                  60                
 Ser Cys Pro Ile Gly Leu Asp Val Arg Asp Ala Gln Ser Phe
  65                  70                  75            



      <210> 1304
      <211> 506
      <212> PRT
      <213> Homo sapiens


      <400> 1304
 Met Glu Ser Ser Pro Glu Ser Leu Gln Pro Leu Glu His Gly Val Ala
   1               5                  10                  15    
 Ala Gly Pro Ala Ser Gly Thr Gly Ser Ser Gln Glu Gly Leu Gln Glu
              20                  25                  30        
 Thr Arg Leu Ala Ala Gly Asp Gly Pro Gly Val Trp Ala Ala Glu Thr
          35                  40                  45            
 Ser Gly Gly Asn Gly Leu Gly Ala Ala Ala Ala Arg Arg Ser Leu Pro
      50                  55                  60                
 Asp Ser Ala Ser Pro Ala Gly Ser Pro Glu Val Pro Gly Pro Cys Ser
  65                  70                  75                  80
 Ser Ser Ala Gly Leu Gly Leu Lys Asp Ser Gly Leu Glu Ser Pro Ala
                  85                  90                  95    
 Ala Ala Glu Ala Pro Leu Cys Lys Glu Glu Glu Gly Glu Glu Thr Ala
             100                 105                 110        
 Gln Val Leu Ala Ala Ser Lys Glu Arg Phe Pro Gly Gln Ser Val Tyr
         115                 120                 125            
 His Ile Lys Trp Ile Gln Trp Lys Glu Glu Asn Thr Pro Ile Ile Thr
     130                 135                 140                
 Gln Asn Glu Asn Gly Pro Cys Pro Leu Leu Ala Ile Leu Asn Val Leu
 145                 150                 155                 160
 Leu Leu Ala Trp Lys Val Lys Leu Pro Pro Met Met Glu Ile Ile Thr
                 165                 170                 175    
 Ala Glu Gln Leu Met Glu Tyr Leu Gly Asp Tyr Met Leu Asp Ala Lys
             180                 185                 190        
 Pro Lys Glu Ile Ser Glu Ile Gln Arg Leu Asn Tyr Glu Gln Asn Met
         195                 200                 205            
 Ser Asp Ala Met Ala Ile Leu His Lys Leu Gln Thr Gly Leu Asp Val
     210                 215                 220                
 Asn Val Arg Phe Thr Gly Val Arg Val Phe Glu Tyr Thr Pro Glu Cys
 225                 230                 235                 240
 Ile Val Phe Asp Leu Leu Asp Ile Pro Leu Tyr His Gly Trp Leu Val
                 245                 250                 255    
 Asp Pro Gln Ile Asp Asp Ile Val Lys Ala Val Gly Asn Cys Ser Tyr
             260                 265                 270        
 Asn Gln Leu Val Glu Lys Ile Ile Ser Cys Lys Gln Ser Asp Asn Ser
         275                 280                 285            
 Glu Leu Val Ser Glu Gly Phe Val Ala Glu Gln Phe Leu Asn Asn Thr
     290                 295                 300                
 Ala Thr Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ser Thr Val
 305                 310                 315                 320
 Gln Glu Gly Glu Leu Cys Val Phe Phe Arg Asn Asn His Phe Ser Thr
                 325                 330                 335    
 Met Thr Lys Tyr Lys Gly Gln Leu Tyr Leu Leu Val Thr Asp Gln Gly
             340                 345                 350        
 Phe Leu Thr Glu Glu Lys Val Val Trp Glu Ser Leu His Asn Val Asp
         355                 360                 365            
 Gly Asp Gly Asn Phe Cys Asp Ser Glu Phe His Leu Arg Pro Pro Ser
     370                 375                 380                
 Asp Pro Glu Thr Val Tyr Lys Gly Gln Gln Asp Gln Ile Asp Gln Asp
 385                 390                 395                 400
 Tyr Leu Met Ala Leu Ser Leu Gln Gln Glu Gln Gln Ser Gln Glu Ile
                 405                 410                 415    
 Asn Trp Glu Gln Ile Pro Glu Gly Ile Ser Asp Leu Glu Leu Ala Lys
             420                 425                 430        
 Lys Leu Gln Glu Glu Glu Asp Arg Arg Ala Ser Gln Tyr Tyr Gln Glu
         435                 440                 445            
 Gln Glu Gln Ala Ala Ala Ala Ala Ala Ala Ala Ser Thr Gln Ala Gln
     450                 455                 460                
 Gln Gly Gln Pro Ala Gln Ala Ser Pro Ser Ser Gly Arg Gln Ser Gly
 465                 470                 475                 480
 Asn Ser Glu Arg Lys Arg Lys Glu Pro Arg Glu Lys Asp Lys Glu Lys
                 485                 490                 495    
 Glu Lys Glu Lys Asn Ser Cys Val Ile Leu
             500                 505    



      <210> 1305
      <211> 621
      <212> PRT
      <213> Homo sapiens


      <400> 1305
 Met Glu Ser Ser Pro Glu Ser Leu Gln Pro Leu Glu His Gly Val Ala
   1               5                  10                  15    
 Ala Gly Pro Ala Ser Gly Thr Gly Ser Ser Gln Glu Gly Leu Gln Glu
              20                  25                  30        
 Thr Arg Leu Ala Ala Gly Asp Gly Pro Gly Val Trp Ala Ala Glu Thr
          35                  40                  45            
 Ser Gly Gly Asn Gly Leu Gly Ala Ala Ala Ala Arg Arg Ser Leu Pro
      50                  55                  60                
 Asp Ser Ala Ser Pro Ala Gly Ser Pro Glu Val Pro Gly Pro Cys Ser
  65                  70                  75                  80
 Ser Ser Ala Gly Leu Asp Leu Lys Asp Ser Gly Leu Glu Ser Pro Ala
                  85                  90                  95    
 Ala Ala Glu Ala Pro Leu Arg Gly Gln Tyr Lys Val Thr Ala Ser Pro
             100                 105                 110        
 Glu Thr Ala Val Ala Gly Val Gly His Glu Leu Gly Thr Ala Gly Asp
         115                 120                 125            
 Ala Gly Ala Arg Pro Asp Leu Ala Gly Thr Cys Gln Ala Glu Leu Thr
     130                 135                 140                
 Ala Ala Gly Ser Glu Glu Pro Ser Ser Ala Gly Gly Leu Ser Ser Ser
 145                 150                 155                 160
 Cys Ser Asp Pro Ser Pro Pro Gly Glu Ser Pro Ser Leu Asp Ser Leu
                 165                 170                 175    
 Glu Ser Phe Ser Asn Leu His Ser Phe Pro Ser Ser Cys Glu Phe Asn
             180                 185                 190        
 Ser Glu Glu Gly Ala Glu Asn Arg Val Pro Glu Glu Glu Glu Gly Ala
         195                 200                 205            
 Ala Val Leu Pro Gly Ala Val Pro Leu Cys Lys Glu Glu Glu Gly Glu
     210                 215                 220                
 Glu Thr Ala Gln Val Leu Ala Ala Ser Lys Glu Arg Phe Pro Gly Gln
 225                 230                 235                 240
 Ser Val Tyr His Ile Lys Trp Ile Gln Trp Lys Glu Glu Asn Thr Pro
                 245                 250                 255    
 Ile Ile Thr Gln Asn Glu Asn Gly Pro Cys Pro Leu Leu Ala Ile Leu
             260                 265                 270        
 Asn Val Leu Leu Leu Ala Trp Lys Val Lys Leu Pro Pro Met Met Glu
         275                 280                 285            
 Ile Ile Thr Ala Glu Gln Leu Met Glu Tyr Leu Gly Asp Tyr Met Leu
     290                 295                 300                
 Asp Ala Lys Pro Lys Glu Ile Ser Glu Ile Gln Arg Leu Asn Tyr Glu
 305                 310                 315                 320
 Gln Asn Met Ser Asp Ala Met Ala Ile Leu His Lys Leu Gln Thr Gly
                 325                 330                 335    
 Leu Asp Val Asn Val Arg Phe Thr Gly Val Arg Val Phe Glu Tyr Thr
             340                 345                 350        
 Pro Glu Cys Ile Val Phe Asp Leu Leu Asp Ile Pro Leu Tyr His Gly
         355                 360                 365            
 Trp Leu Val Asp Pro Gln Ile Asp Asp Ile Val Lys Ala Val Gly Asn
     370                 375                 380                
 Cys Ser Tyr Asn Gln Leu Val Glu Lys Ile Ile Ser Cys Lys Gln Ser
 385                 390                 395                 400
 Asp Asn Ser Glu Leu Val Ser Glu Gly Phe Val Ala Glu Gln Phe Leu
                 405                 410                 415    
 Asn Asn Thr Ala Thr Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr
             420                 425                 430        
 Ser Thr Val Gln Glu Gly Glu Leu Cys Val Phe Phe Arg Asn Asn His
         435                 440                 445            
 Phe Ser Thr Met Thr Lys Tyr Lys Gly Gln Leu Tyr Leu Leu Val Thr
     450                 455                 460                
 Asp Gln Gly Phe Leu Thr Glu Glu Lys Val Val Trp Glu Ser Leu His
 465                 470                 475                 480
 Asn Val Asp Gly Asp Gly Asn Phe Cys Asp Ser Glu Phe His Leu Arg
                 485                 490                 495    
 Pro Pro Ser Asp Pro Glu Thr Val Tyr Lys Gly Gln Gln Asp Gln Ile
             500                 505                 510        
 Asp Gln Asp Tyr Leu Met Ala Leu Ser Leu Gln Gln Glu Gln Gln Ser
         515                 520                 525            
 Gln Glu Ile Asn Trp Glu Gln Ile Pro Glu Gly Ile Ser Asp Leu Glu
     530                 535                 540                
 Leu Ala Lys Lys Leu Gln Glu Glu Glu Asp Arg Arg Ala Ser Gln Tyr
 545                 550                 555                 560
 Tyr Gln Glu Gln Glu Gln Ala Ala Ala Ala Ala Ala Ala Ala Ser Thr
                 565                 570                 575    
 Gln Ala Gln Gln Gly Gln Pro Ala Gln Ala Ser Pro Ser Ser Gly Arg
             580                 585                 590        
 Gln Ser Gly Asn Ser Glu Arg Lys Arg Lys Glu Pro Arg Glu Lys Asp
         595                 600                 605            
 Lys Glu Lys Glu Lys Glu Lys Asn Ser Cys Val Ile Leu
     610                 615                 620    



      <210> 1306
      <211> 630
      <212> PRT
      <213> Homo sapiens


      <400> 1306
 Met Trp Lys Gly Ser Ser Ser Met Leu Ile Tyr Val Arg Ser Asp Pro
   1               5                  10                  15    
 Tyr His Lys Asp Asp Asn Ile Gln Ile Gly Arg Glu Val Lys Ile Ser
              20                  25                  30        
 Cys Gln Val Glu Ala Val Pro Ser Glu Glu Leu Thr Phe Ser Trp Phe
          35                  40                  45            
 Lys Asn Gly Arg Pro Leu Arg Ser Ser Glu Arg Met Val Ile Thr Gln
      50                  55                  60                
 Thr Asp Pro Asp Val Ser Pro Gly Thr Thr Asn Leu Asp Ile Ile Asp
  65                  70                  75                  80
 Leu Lys Phe Thr Asp Phe Gly Thr Tyr Thr Cys Val Ala Ser Leu Lys
                  85                  90                  95    
 Gly Gly Gly Ile Ser Asp Ile Ser Ile Asp Val Asn Ile Ser Ser Ser
             100                 105                 110        
 Thr Val Pro Pro Asn Leu Thr Val Pro Gln Glu Lys Ser Pro Leu Val
         115                 120                 125            
 Thr Arg Glu Gly Asp Thr Ile Glu Leu Gln Cys Gln Val Thr Gly Lys
     130                 135                 140                
 Pro Lys Pro Ile Ile Leu Trp Ser Arg Ala Asp Lys Glu Val Ala Met
 145                 150                 155                 160
 Pro Asp Gly Ser Met Gln Met Glu Ser Tyr Asp Gly Thr Leu Arg Ile
                 165                 170                 175    
 Val Asn Val Ser Arg Glu Met Ser Gly Met Tyr Arg Cys Gln Thr Ser
             180                 185                 190        
 Gln Tyr Asn Gly Phe Asn Val Lys Pro Arg Glu Ala Leu Val Gln Leu
         195                 200                 205            
 Ile Val Gln Tyr Pro Pro Ala Val Glu Pro Ala Phe Leu Glu Ile Arg
     210                 215                 220                
 Gln Gly Gln Asp Arg Ser Val Thr Met Ser Cys Arg Val Leu Arg Ala
 225                 230                 235                 240
 Tyr Pro Ile Arg Val Leu Thr Tyr Glu Trp Arg Leu Gly Asn Lys Leu
                 245                 250                 255    
 Leu Arg Thr Gly Gln Phe Asp Ser Gln Glu Tyr Thr Glu Tyr Ala Val
             260                 265                 270        
 Lys Ser Leu Ser Asn Glu Asn Tyr Gly Val Tyr Asn Cys Ser Ile Ile
         275                 280                 285            
 Asn Glu Ala Gly Ala Gly Arg Cys Ser Phe Leu Val Thr Gly Lys Ala
     290                 295                 300                
 Tyr Ala Pro Glu Phe Tyr Tyr Asp Thr Tyr Asn Pro Val Trp Gln Asn
 305                 310                 315                 320
 Arg His Arg Val Tyr Ser Tyr Ser Leu Gln Trp Thr Gln Met Asn Pro
                 325                 330                 335    
 Asp Ala Val Asp Arg Ile Val Ala Tyr Arg Leu Gly Ile Arg Gln Ala
             340                 345                 350        
 Gly Gln Gln Arg Trp Trp Glu Gln Glu Ile Lys Ile Asn Gly Asn Ile
         355                 360                 365            
 Gln Lys Gly Glu Leu Ile Thr Tyr Asn Leu Thr Glu Leu Ile Lys Pro
     370                 375                 380                
 Glu Ala Tyr Glu Val Arg Leu Thr Pro Leu Thr Lys Phe Gly Glu Gly
 385                 390                 395                 400
 Asp Ser Thr Ile Arg Val Ile Lys Tyr Ser Ala Pro Val Asn Pro His
                 405                 410                 415    
 Leu Arg Glu Phe His Cys Gly Phe Glu Asp Gly Asn Ile Cys Leu Phe
             420                 425                 430        
 Thr Gln Asp Asp Thr Asp Asn Phe Asp Trp Thr Lys Gln Ser Thr Ala
         435                 440                 445            
 Thr Arg Asn Thr Lys Tyr Thr Pro Asn Thr Gly Pro Asn Ala Asp Arg
     450                 455                 460                
 Ser Gly Ser Lys Glu Gly Phe Tyr Met Tyr Ile Glu Thr Ser Arg Pro
 465                 470                 475                 480
 Arg Leu Glu Gly Glu Lys Ala Arg Leu Leu Ser Pro Val Phe Ser Ile
                 485                 490                 495    
 Ala Pro Lys Asn Pro Tyr Gly Pro Thr Asn Thr Ala Tyr Cys Phe Ser
             500                 505                 510        
 Phe Phe Tyr His Met Tyr Gly Gln His Ile Gly Val Leu Asn Val Tyr
         515                 520                 525            
 Leu Arg Leu Lys Gly Gln Thr Thr Ile Glu Asn Pro Leu Trp Ser Ser
     530                 535                 540                
 Ser Gly Asn Lys Gly Gln Arg Trp Asn Glu Ala His Val Asn Ile Tyr
 545                 550                 555                 560
 Pro Ile Thr Ser Phe Gln Leu Ile Phe Glu Gly Ile Arg Gly Pro Gly
                 565                 570                 575    
 Ile Glu Gly Asp Ile Ala Ile Asp Asp Val Ser Ile Ala Glu Gly Glu
             580                 585                 590        
 Cys Ala Lys Gln Asp Leu Ala Thr Lys Asn Ser Val Asp Gly Ala Val
         595                 600                 605            
 Gly Ile Leu Val His Ile Trp Leu Phe Pro Ile Ile Val Leu Ile Ser
     610                 615                 620                
 Ile Leu Ser Pro Arg Arg
 625                 630



      <210> 1307
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 1307
 Met Arg Arg Leu Ser Ile Val Met Lys Asn Pro Trp His Ser Pro His
   1               5                  10                  15    
 Pro Gln Thr His Gly Ser His Ser His Thr Gly Pro Lys Ala Thr Val
              20                  25                  30        
 Ser Ala Ala Val Ala Pro Val Asp Ile Gly Lys Pro Gly Glu Gly Val
          35                  40                  45            
 Glu Glu Ile Ser Trp Pro Pro Ala Gly Ser Leu Gly Phe Cys Ala Gln
      50                  55                  60                
 Gly Ser Trp Ser Pro Lys Asn Phe Gln Lys Leu Thr Pro His Val Pro
  65                  70                  75                  80
 Ile Leu Leu Gly Phe Leu Asp Phe Ser Glu Ala Pro Ala Glu Gly Ser
                  85                  90                  95    
 Arg Cys Ser Leu Glu Cys Arg Gly Ser Pro Leu Thr Trp Leu Leu Glu
             100                 105                 110        
 Ser Leu Leu Phe Leu Leu Leu Leu Pro Ser Ser Ser Ser Ser Ser Leu
         115                 120                 125            
 Ser Ile Ser Pro Ser Leu Cys Pro Ser Pro Val Pro Asp Leu Ala Ile
     130                 135                 140                
 Pro Gly Cys Pro
 145            



      <210> 1308
      <211> 780
      <212> PRT
      <213> Homo sapiens


      <400> 1308
 Met Lys Pro Gly Ala Thr Gly Glu Ser Asp Leu Ala Glu Val Leu Pro
   1               5                  10                  15    
 Gln His Lys Phe Asp Ser Lys Ser Leu Glu Ala Tyr Leu Asn Gln His
              20                  25                  30        
 Leu Ser Gly Phe Gly Ala Glu Arg Glu Ala Thr Leu Thr Ile Ala Gln
          35                  40                  45            
 Tyr Arg Ala Gly Lys Ser Asn Pro Thr Phe Tyr Leu Gln Lys Gly Phe
      50                  55                  60                
 Gln Thr Tyr Val Leu Arg Lys Lys Pro Pro Gly Ser Leu Leu Pro Lys
  65                  70                  75                  80
 Ala His Gln Ile Asp Arg Glu Phe Lys Val Gln Lys Ala Leu Phe Ser
                  85                  90                  95    
 Ile Gly Phe Pro Val Pro Lys Pro Ile Leu Tyr Cys Ser Asp Thr Ser
             100                 105                 110        
 Val Ile Gly Thr Glu Phe Tyr Val Met Glu His Val Gln Gly Arg Ile
         115                 120                 125            
 Phe Arg Asp Leu Thr Ile Pro Gly Leu Ser Pro Ala Glu Arg Ser Ala
     130                 135                 140                
 Ile Tyr Val Ala Thr Val Glu Thr Leu Ala Gln Leu His Ser Leu Asn
 145                 150                 155                 160
 Ile Gln Ser Leu Gln Leu Glu Gly Tyr Gly Ile Gly Ala Gly Tyr Cys
                 165                 170                 175    
 Lys Arg Gln Val Ser Thr Trp Thr Lys Gln Tyr Gln Ala Ala Ala His
             180                 185                 190        
 Gln Asp Ile Pro Ala Met Gln Gln Leu Ser Glu Trp Leu Met Lys Asn
         195                 200                 205            
 Leu Pro Asp Asn Asp Asn Glu Glu Asn Leu Ile His Gly Asp Phe Arg
     210                 215                 220                
 Leu Asp Asn Ile Val Phe His Pro Lys Glu Cys Arg Val Ile Ala Val
 225                 230                 235                 240
 Leu Asp Trp Glu Leu Ser Thr Ile Gly His Pro Leu Ser Asp Leu Ala
                 245                 250                 255    
 His Phe Ser Leu Phe Tyr Phe Trp Pro Arg Thr Val Pro Met Ile Asn
             260                 265                 270        
 Gln Gly Ser Tyr Ser Glu Asn Ser Gly Ile Pro Ser Met Glu Glu Leu
         275                 280                 285            
 Ile Ser Ile Tyr Cys Arg Cys Arg Gly Ile Asn Ser Ile Leu Pro Asn
     290                 295                 300                
 Trp Asn Phe Phe Leu Ala Leu Ser Tyr Phe Lys Met Ala Gly Ile Ala
 305                 310                 315                 320
 Gln Gly Val Tyr Ser Arg Tyr Leu Leu Gly Asn Asn Ser Ser Glu Asp
                 325                 330                 335    
 Ser Phe Leu Phe Ala Asn Ile Val Gln Pro Leu Ala Glu Thr Gly Leu
             340                 345                 350        
 Gln Leu Ser Lys Arg Thr Phe Ser Thr Val Leu Pro Gln Ile Asp Thr
         355                 360                 365            
 Thr Gly Gln Leu Phe Val Gln Thr Arg Lys Gly Gln Glu Val Leu Ile
     370                 375                 380                
 Lys Val Lys His Phe Met Lys Gln His Ile Leu Pro Ala Glu Lys Glu
 385                 390                 395                 400
 Val Thr Glu Phe Tyr Val Gln Asn Glu Asn Ser Val Asp Lys Trp Gly
                 405                 410                 415    
 Lys Pro Leu Val Ile Asp Lys Leu Lys Glu Met Ala Lys Val Glu Gly
             420                 425                 430        
 Leu Trp Asn Leu Phe Leu Pro Ala Val Ser Gly Leu Ser His Val Asp
         435                 440                 445            
 Tyr Ala Leu Ile Ala Glu Glu Thr Gly Lys Cys Phe Phe Ala Pro Asp
     450                 455                 460                
 Val Phe Asn Cys Gln Ala Pro Asp Thr Gly Asn Met Glu Val Leu His
 465                 470                 475                 480
 Leu Tyr Gly Ser Glu Glu Gln Lys Lys Gln Trp Leu Glu Pro Leu Leu
                 485                 490                 495    
 Gln Gly Asn Ile Thr Ser Cys Phe Cys Met Thr Glu Pro Asp Val Ala
             500                 505                 510        
 Ser Ser Asp Ala Thr Asn Ile Glu Cys Ser Ile Gln Arg Asp Glu Asp
         515                 520                 525            
 Ser Tyr Val Ile Asn Gly Lys Lys Trp Trp Ser Ser Gly Ala Gly Asn
     530                 535                 540                
 Pro Lys Cys Lys Val Ala Ile Val Leu Gly Arg Thr Gln Asn Thr Ser
 545                 550                 555                 560
 Leu Ser Arg His Lys Gln His Ser Met Ile Leu Gly Pro Met Asn Thr
                 565                 570                 575    
 Pro Gly Val Lys Ile Ile Arg Pro Leu Ser Val Phe Gly Tyr Thr Asp
             580                 585                 590        
 Asn Phe His Gly Gly His Phe Glu Ile His Phe Asn Gln Val Arg Val
         595                 600                 605            
 Pro Ala Thr Asn Leu Ile Leu Gly Glu Gly Arg Gly Phe Glu Ile Ser
     610                 615                 620                
 Gln Gly Arg Leu Gly Pro Gly Arg Ile His His Cys Met Arg Thr Val
 625                 630                 635                 640
 Gly Leu Ala Glu Arg Ala Leu Gln Ile Met Cys Glu Arg Ala Thr Gln
                 645                 650                 655    
 Arg Ile Ala Phe Lys Lys Lys Leu Tyr Ala His Glu Val Val Ala His
             660                 665                 670        
 Trp Ile Ala Glu Ser Arg Ile Ala Ile Glu Lys Ile Arg Leu Leu Thr
         675                 680                 685            
 Leu Lys Ala Ala His Ser Met Asp Thr Leu Gly Ser Ala Gly Ala Lys
     690                 695                 700                
 Lys Glu Ile Ala Met Ile Lys Val Ala Ala Pro Arg Ala Val Ser Lys
 705                 710                 715                 720
 Ile Val Asp Trp Ala Ile Gln Val Cys Gly Gly Ala Gly Val Ser Gln
                 725                 730                 735    
 Asp Tyr Pro Leu Ala Asn Met Tyr Ala Ile Thr Arg Val Leu Arg Leu
             740                 745                 750        
 Ala Asp Gly Pro Asp Glu Val His Leu Ser Ala Ile Ala Thr Met Glu
         755                 760                 765            
 Leu Arg Asp Gln Ala Lys Arg Leu Thr Ala Lys Ile
     770                 775                 780



      <210> 1309
      <211> 762
      <212> PRT
      <213> Homo sapiens


      <400> 1309
 Met Lys Pro Gly Ala Thr Gly Glu Ser Asp Leu Ala Glu Val Leu Pro
   1               5                  10                  15    
 Gln His Lys Phe Asp Ser Lys Ser Leu Glu Ala Tyr Leu Asn Gln His
              20                  25                  30        
 Leu Ser Gly Phe Gly Ala Glu Arg Glu Ala Thr Leu Thr Ile Ala Gln
          35                  40                  45            
 Tyr Arg Ala Gly Lys Ser Asn Pro Thr Phe Tyr Leu Gln Lys Gly Phe
      50                  55                  60                
 Gln Thr Tyr Val Leu Arg Lys Val Gln Lys Ala Leu Phe Ser Ile Gly
  65                  70                  75                  80
 Phe Pro Val Pro Lys Pro Ile Leu Tyr Cys Ser Asp Thr Ser Val Ile
                  85                  90                  95    
 Gly Thr Glu Phe Tyr Val Met Glu His Val Gln Gly Arg Ile Phe Arg
             100                 105                 110        
 Asp Leu Thr Ile Pro Gly Leu Ser Pro Ala Glu Arg Ser Ala Ile Tyr
         115                 120                 125            
 Val Ala Thr Val Glu Thr Leu Ala Gln Leu His Ser Leu Asn Ile Gln
     130                 135                 140                
 Ser Leu Gln Leu Glu Gly Tyr Gly Ile Gly Ala Gly Tyr Cys Lys Arg
 145                 150                 155                 160
 Gln Val Ser Thr Trp Thr Lys Gln Tyr Gln Ala Ala Ala His Gln Asp
                 165                 170                 175    
 Ile Pro Ala Met Gln Gln Leu Ser Glu Trp Leu Met Lys Asn Leu Pro
             180                 185                 190        
 Asp Asn Asp Asn Glu Glu Asn Leu Ile His Gly Asp Phe Arg Leu Asp
         195                 200                 205            
 Asn Ile Val Phe His Pro Lys Glu Cys Arg Val Ile Ala Val Leu Asp
     210                 215                 220                
 Trp Glu Leu Ser Thr Ile Gly His Pro Leu Ser Asp Leu Ala His Phe
 225                 230                 235                 240
 Ser Leu Phe Tyr Phe Trp Pro Arg Thr Val Pro Met Ile Asn Gln Gly
                 245                 250                 255    
 Ser Tyr Ser Glu Asn Ser Gly Ile Pro Ser Met Glu Glu Leu Ile Ser
             260                 265                 270        
 Ile Tyr Cys Arg Cys Arg Gly Ile Asn Ser Ile Leu Pro Asn Trp Asn
         275                 280                 285            
 Phe Phe Leu Ala Leu Ser Tyr Phe Lys Met Ala Gly Ile Ala Gln Gly
     290                 295                 300                
 Val Tyr Ser Arg Tyr Leu Leu Gly Asn Asn Ser Ser Glu Asp Ser Phe
 305                 310                 315                 320
 Leu Phe Ala Asn Ile Val Gln Pro Leu Ala Glu Thr Gly Leu Gln Leu
                 325                 330                 335    
 Ser Lys Arg Thr Phe Ser Thr Val Leu Pro Gln Ile Asp Thr Thr Gly
             340                 345                 350        
 Gln Leu Phe Val Gln Thr Arg Lys Gly Gln Glu Val Leu Ile Lys Val
         355                 360                 365            
 Lys His Phe Met Lys Gln His Ile Leu Pro Ala Glu Lys Glu Val Thr
     370                 375                 380                
 Glu Phe Tyr Val Gln Asn Glu Asn Ser Val Asp Lys Trp Gly Lys Pro
 385                 390                 395                 400
 Leu Val Ile Asp Lys Leu Lys Glu Met Ala Lys Val Glu Gly Leu Trp
                 405                 410                 415    
 Asn Leu Phe Leu Pro Ala Val Ser Gly Leu Ser His Val Asp Tyr Ala
             420                 425                 430        
 Leu Ile Ala Glu Glu Thr Gly Lys Cys Phe Phe Ala Pro Asp Val Phe
         435                 440                 445            
 Asn Cys Gln Ala Pro Asp Thr Gly Asn Met Glu Val Leu His Leu Tyr
     450                 455                 460                
 Gly Ser Glu Glu Gln Lys Lys Gln Trp Leu Glu Pro Leu Leu Gln Gly
 465                 470                 475                 480
 Asn Ile Thr Ser Cys Phe Cys Met Thr Glu Pro Asp Val Ala Ser Ser
                 485                 490                 495    
 Asp Ala Thr Asn Ile Glu Cys Ser Ile Gln Arg Asp Glu Asp Ser Tyr
             500                 505                 510        
 Val Ile Asn Gly Lys Lys Trp Trp Ser Ser Gly Ala Gly Asn Pro Lys
         515                 520                 525            
 Cys Lys Val Ala Ile Val Leu Gly Arg Thr Gln Asn Thr Ser Leu Ser
     530                 535                 540                
 Arg His Lys Gln His Ser Met Ile Leu Gly Pro Met Asn Thr Pro Gly
 545                 550                 555                 560
 Val Lys Ile Ile Arg Pro Leu Ser Val Phe Gly Tyr Thr Asp Asn Phe
                 565                 570                 575    
 His Gly Gly His Phe Glu Ile His Phe Asn Gln Val Arg Val Pro Ala
             580                 585                 590        
 Thr Asn Leu Ile Leu Gly Glu Gly Arg Gly Phe Glu Ile Ser Gln Gly
         595                 600                 605            
 Arg Leu Gly Pro Gly Arg Ile His His Cys Met Arg Thr Val Gly Leu
     610                 615                 620                
 Ala Glu Arg Ala Leu Gln Ile Met Cys Glu Arg Ala Thr Gln Arg Ile
 625                 630                 635                 640
 Ala Phe Lys Lys Lys Leu Tyr Ala His Glu Val Val Ala His Trp Ile
                 645                 650                 655    
 Ala Glu Ser Arg Ile Ala Ile Glu Lys Ile Arg Leu Leu Thr Leu Lys
             660                 665                 670        
 Ala Ala His Ser Met Asp Thr Leu Gly Ser Ala Gly Ala Lys Lys Glu
         675                 680                 685            
 Ile Ala Met Ile Lys Val Ala Ala Pro Arg Ala Val Ser Lys Ile Val
     690                 695                 700                
 Asp Trp Ala Ile Gln Val Cys Gly Gly Ala Gly Val Ser Gln Asp Tyr
 705                 710                 715                 720
 Pro Leu Ala Asn Met Tyr Ala Ile Thr Arg Val Leu Arg Leu Ala Asp
                 725                 730                 735    
 Gly Pro Asp Glu Val His Leu Ser Ala Ile Ala Thr Met Glu Leu Arg
             740                 745                 750        
 Asp Gln Ala Lys Arg Leu Thr Ala Lys Ile
         755                 760        



      <210> 1310
      <211> 222
      <212> PRT
      <213> Homo sapiens


      <400> 1310
 Met Gly Thr Ile His Leu Phe Arg Lys Pro Gln Arg Ser Phe Phe Gly
   1               5                  10                  15    
 Lys Leu Leu Arg Glu Phe Arg Leu Val Ala Ala Asp Arg Arg Ser Trp
              20                  25                  30        
 Lys Ile Leu Leu Phe Gly Val Ile Asn Leu Ile Cys Thr Gly Phe Leu
          35                  40                  45            
 Leu Met Trp Cys Ser Ser Thr Asn Arg Ile Ala Leu Thr Ala Tyr Thr
      50                  55                  60                
 Tyr Leu Thr Ile Phe Asp Leu Phe Ser Leu Met Thr Cys Leu Ile Ser
  65                  70                  75                  80
 Tyr Trp Val Thr Leu Arg Lys Pro Ser Pro Val Tyr Ser Phe Gly Phe
                  85                  90                  95    
 Glu Arg Leu Glu Val Leu Ala Val Phe Ala Ser Thr Val Leu Ala Gln
             100                 105                 110        
 Leu Gly Ala Leu Phe Ile Leu Lys Glu Ser Ala Glu Arg Phe Leu Glu
         115                 120                 125            
 Gln Pro Glu Ile His Thr Gly Arg Leu Leu Val Gly Thr Phe Val Ala
     130                 135                 140                
 Leu Cys Phe Asn Leu Phe Thr Met Leu Ser Ile Arg Asn Lys Pro Phe
 145                 150                 155                 160
 Ala Tyr Val Ser Glu Ala Ala Ser Thr Ser Trp Leu Gln Glu His Val
                 165                 170                 175    
 Ala Asp Leu Ser Arg Ser Leu Cys Gly Ile Ile Pro Gly Leu Ser Ser
             180                 185                 190        
 Ile Phe Leu Pro Arg Met Asn Pro Phe Val Leu Ile Asp Leu Ala Gly
         195                 200                 205            
 Ala Phe Ala Leu Cys Ile Thr Tyr Met Leu Ile Glu Ile Lys
     210                 215                 220        



      <210> 1311
      <211> 820
      <212> PRT
      <213> Homo sapiens


      <400> 1311
 Met Ala Val Tyr Val Gly Thr Cys Val Arg Cys Val Arg Ser Gly Val
   1               5                  10                  15    
 Cys Leu Ala Val Pro Val Gly Met Cys Val Arg His Ile His Ile Gly
              20                  25                  30        
 Val Cys Val Ala Val Cys Ala Gly Thr Cys Val Arg Arg Ala Arg Ile
          35                  40                  45            
 Gly Val Cys Met Ala Val Arg Ala Gly Thr Cys Val Arg Arg Ala Arg
      50                  55                  60                
 Ile Gly Val Tyr Leu Ala Val Arg Ala Gly Thr Cys Val Arg Arg Ile
  65                  70                  75                  80
 Arg Ile Gly Val Cys Val Ala Val Arg Ala Gly Thr Cys Val Arg Arg
                  85                  90                  95    
 Ala Arg Ile Gly Val Cys Val Ala Val Arg Ala Gly Thr Cys Val Arg
             100                 105                 110        
 Arg Ala Arg Ile Gly Val Cys Val Ala Val Arg Ala Gly Thr Cys Val
         115                 120                 125            
 Arg Arg Ala Arg Ile Gly Val Cys Val Ala Val Arg Ala Gly Thr Cys
     130                 135                 140                
 Val Arg Arg Ile Arg Ile Gly Val Cys Val Ala Val Arg Ala Gly Thr
 145                 150                 155                 160
 Cys Val Arg Arg Ile Arg Ile Gly Val Cys Val Ala Val Arg Ala Gly
                 165                 170                 175    
 Thr Cys Val Arg Arg Ala Arg Ile Gly Val Cys Val Ala Val Arg Ala
             180                 185                 190        
 Gly Thr Cys Val Arg Arg Ala Arg Ile Gly Val Cys Val Ala Val Arg
         195                 200                 205            
 Ala Gly Thr Cys Val Arg Arg Ala Arg Ser Val Val Cys Val Ala Val
     210                 215                 220                
 Arg Ala Gly Thr Cys Val Arg Arg Ala Arg Ser Gly Val Cys Val Ala
 225                 230                 235                 240
 Val Arg Ala Gly Thr Cys Val Arg Arg Val Arg Ile Gly Val Tyr Leu
                 245                 250                 255    
 Ala Val Arg Ala Gly Thr Cys Val Arg Arg Val Arg Ile Gly Val Tyr
             260                 265                 270        
 Leu Ala Val Arg Ala Gly Thr Cys Val Arg Arg Val Arg Ile Gly Val
         275                 280                 285            
 Cys Val Ala Val Cys Ala Gly Thr Cys Val Arg Arg Ala Arg Ser Gly
     290                 295                 300                
 Val Cys Val Ala Val Arg Val Gly Thr Cys Val Arg Arg Ala Arg Ile
 305                 310                 315                 320
 Gly Val Cys Val Ala Val Cys Ala Gly Thr Cys Val Arg Arg Val Arg
                 325                 330                 335    
 Ser Phe Val Trp Met Ala Val His Gly Pro Cys Phe Leu Gln Ser Leu
             340                 345                 350        
 His Val Gln Lys Ser Asp Val Asp Leu Met Arg Thr Lys Leu Arg Arg
         355                 360                 365            
 Leu Glu Glu Glu Asn Ser Arg Lys Asp Arg Gln Ile Glu Gln Leu Leu
     370                 375                 380                
 Asp Pro Ser Arg Gly Thr Asp Phe Val Arg Thr Leu Ala Glu Lys Arg
 385                 390                 395                 400
 Pro Asp Ala Ser Trp Val Ile Asn Gly Leu Lys Gln Arg Ile Leu Lys
                 405                 410                 415    
 Leu Glu Gln Gln Cys Lys Glu Lys Asp Gly Thr Ile Ser Lys Leu Gln
             420                 425                 430        
 Thr Asp Met Lys Thr Thr Asn Leu Glu Glu Met Arg Ile Ala Met Glu
         435                 440                 445            
 Thr Tyr Tyr Glu Glu Val His Arg Leu Gln Thr Leu Leu Ala Ser Ser
     450                 455                 460                
 Glu Thr Thr Gly Lys Lys Pro Leu Gly Glu Lys Lys Thr Gly Ala Lys
 465                 470                 475                 480
 Arg Gln Lys Lys Met Gly Ser Ala Leu Leu Ser Leu Ser Arg Ser Val
                 485                 490                 495    
 Gln Glu Leu Thr Glu Glu Asn Gln Ser Leu Lys Glu Asp Leu Asp Arg
             500                 505                 510        
 Val Leu Ser Thr Ser Pro Thr Ile Ser Lys Thr Gln Gly Tyr Val Glu
         515                 520                 525            
 Trp Ser Lys Pro Arg Leu Leu Arg Arg Ile Val Glu Leu Glu Lys Lys
     530                 535                 540                
 Leu Ser Val Met Glu Ser Ser Lys Ser His Ala Ala Glu Pro Val Arg
 545                 550                 555                 560
 Ser His Pro Pro Ala Cys Leu Ala Ser Ser Ser Ala Leu His Arg Gln
                 565                 570                 575    
 Pro Arg Gly Asp Arg Asn Lys Asp His Glu Arg Leu Arg Gly Ala Val
             580                 585                 590        
 Arg Asp Leu Lys Glu Glu Arg Thr Ala Leu Gln Glu Gln Leu Leu Gln
         595                 600                 605            
 Arg Asp Leu Glu Val Lys Gln Leu Leu Gln Ala Lys Ala Asp Leu Glu
     610                 615                 620                
 Lys Glu Leu Glu Cys Ala Arg Glu Gly Glu Glu Glu Arg Arg Glu Arg
 625                 630                 635                 640
 Glu Glu Val Leu Arg Glu Glu Ile Gln Thr Leu Thr Ser Lys Leu Gln
                 645                 650                 655    
 Glu Leu Gln Glu Met Lys Lys Glu Glu Lys Glu Asp Cys Pro Glu Val
             660                 665                 670        
 Pro His Lys Ala Gln Glu Leu Pro Ala Pro Thr Pro Ser Ser Arg His
         675                 680                 685            
 Cys Glu Gln Asp Trp Pro Pro Asp Ser Ser Glu Glu Gly Leu Pro Arg
     690                 695                 700                
 Pro Arg Ser Pro Cys Ser Asp Gly Arg Arg Asp Ala Ala Ala Arg Val
 705                 710                 715                 720
 Leu Gln Ala Gln Trp Lys Val Tyr Lys His Lys Lys Lys Lys Ala Val
                 725                 730                 735    
 Leu Asp Glu Ala Ala Val Val Leu Gln Ala Ala Phe Arg Gly His Leu
             740                 745                 750        
 Thr Arg Thr Lys Leu Leu Ala Ser Lys Ala His Gly Ser Glu Pro Pro
         755                 760                 765            
 Ser Arg Ala Arg Pro Pro Arg Pro Glu Leu Ser Cys Ala Pro Arg Ser
     770                 775                 780                
 Glu Pro His Arg Pro Gly His Gly Gln Pro Cys Ala Gly Gly Gly His
 785                 790                 795                 800
 Arg His His Pro Val Arg Ser Ala Gly Thr Pro Gly Pro Gly Gln Ala
                 805                 810                 815    
 Gln Cys Tyr Arg
             820



      <210> 1312
      <211> 635
      <212> PRT
      <213> Homo sapiens


      <400> 1312
 Met Lys Ala Asp Arg Lys Arg Leu Lys Gly Glu Lys Thr Asp Leu Val
   1               5                  10                  15    
 Ser Gln Met Gln Gln Leu Tyr Ala Thr Leu Glu Ser Arg Glu Glu Gln
              20                  25                  30        
 Leu Arg Asp Phe Ile Arg Asn Tyr Glu Gln His Arg Lys Glu Ser Glu
          35                  40                  45            
 Asp Ala Val Lys Ala Leu Ala Lys Glu Lys Asp Leu Leu Glu Arg Glu
      50                  55                  60                
 Lys Trp Glu Leu Arg Arg Gln Ala Lys Glu Ala Thr Asp His Ala Thr
  65                  70                  75                  80
 Ala Leu Arg Ser Gln Leu Asp Leu Lys Asp Asn Arg Met Lys Glu Leu
                  85                  90                  95    
 Glu Ala Glu Leu Ala Met Ala Lys Gln Ser Leu Ala Thr Leu Thr Lys
             100                 105                 110        
 Asp Val Pro Lys Arg His Ser Leu Ala Met Pro Gly Glu Thr Val Leu
         115                 120                 125            
 Asn Gly Asn Gln Glu Trp Val Val Gln Ala Asp Leu Pro Leu Thr Ala
     130                 135                 140                
 Ala Ile Arg Gln Ser Gln Gln Thr Leu Tyr His Ser His Pro Pro His
 145                 150                 155                 160
 Pro Ala Asp Arg Gln Ala Val Arg Val Ser Pro Cys His Ser Arg Gln
                 165                 170                 175    
 Pro Ser Val Ile Ser Asp Ala Ser Ala Ala Glu Gly Asp Arg Ser Ser
             180                 185                 190        
 Thr Pro Ser Asp Ile Asn Ser Pro Arg His Arg Thr His Ser Leu Cys
         195                 200                 205            
 Asn Gly Asp Ser Pro Gly Pro Val Gln Lys Asn Leu His Asn Pro Ile
     210                 215                 220                
 Val Gln Ser Leu Glu Asp Leu Glu Asp Gln Lys Arg Lys Lys Lys Lys
 225                 230                 235                 240
 Glu Lys Met Gly Phe Gly Ser Ile Ser Arg Val Phe Ala Arg Gly Lys
                 245                 250                 255    
 Gln Arg Lys Ser Leu Asp Pro Gly Leu Phe Asp Asp Ser Asp Ser Gln
             260                 265                 270        
 Cys Ser Pro Thr Arg Gln Ser Leu Ser Leu Ser Glu Gly Glu Glu Gln
         275                 280                 285            
 Met Asp Arg Leu Gln Gln Val Glu Leu Val Arg Thr Thr Pro Met Ser
     290                 295                 300                
 His Trp Lys Ala Gly Thr Val Gln Ala Trp Leu Glu Val Val Met Ala
 305                 310                 315                 320
 Met Pro Met Tyr Val Lys Ala Cys Thr Glu Asn Val Lys Ser Gly Lys
                 325                 330                 335    
 Val Leu Leu Ser Leu Ser Asp Glu Asp Leu Gln Leu Gly Leu Gly Val
             340                 345                 350        
 Cys Ser Ser Leu His Arg Arg Lys Leu Arg Leu Ala Ile Glu Asp Tyr
         355                 360                 365            
 Arg Asp Ala Glu Ala Gly Arg Ser Leu Ser Lys Ala Ala Glu Leu Asp
     370                 375                 380                
 His His Trp Val Ala Lys Ala Trp Leu Asn Asp Ile Gly Leu Ser Gln
 385                 390                 395                 400
 Tyr Ser Gln Ala Phe Gln Asn His Leu Val Asp Gly Arg Met Leu Asn
                 405                 410                 415    
 Ser Leu Met Lys Arg Asp Leu Glu Lys His Leu Asn Val Ser Lys Lys
             420                 425                 430        
 Phe His Gln Val Ser Ile Leu Leu Gly Ile Glu Leu Leu Tyr Gln Val
         435                 440                 445            
 Asn Phe Ser Arg Glu Ala Leu Gln Glu Arg Arg Ala Arg Cys Glu Thr
     450                 455                 460                
 Gln Asn Ile Asp Pro Val Val Trp Thr Asn Gln Arg Val Leu Lys Trp
 465                 470                 475                 480
 Val Arg Asp Ile Asp Leu Lys Glu Tyr Ala Asp Asn Leu Thr Asn Ser
                 485                 490                 495    
 Gly Val His Gly Ala Val Leu Val Leu Glu Pro Thr Phe Asn Ala Glu
             500                 505                 510        
 Ala Met Ala Thr Ala Leu Gly Ile Pro Ser Gly Lys His Ile Leu Arg
         515                 520                 525            
 Arg His Leu Ala Glu Glu Met Ser Ala Val Phe His Pro Ala Asn Ser
     530                 535                 540                
 Thr Gly Ile Arg Glu Ala Glu Arg Phe Gly Thr Pro Pro Gly Arg Ala
 545                 550                 555                 560
 Ser Ser Val Thr Arg Thr Gly Lys Glu Glu Asn Ser Ser Gly Leu Lys
                 565                 570                 575    
 Tyr Lys Ala Gly Arg Leu Pro Leu Gly Lys Ile Gly Arg Gly Phe Ser
             580                 585                 590        
 Ser Lys Asp Pro Asp Phe His Asp Asp Tyr Gly Ser Leu Gln Asn Glu
         595                 600                 605            
 Asp Cys Gly Asp Asp Asp Pro Gln Ser Arg Leu Glu Gln Cys Arg Leu
     610                 615                 620                
 Glu Gly Tyr Asn Ser Leu Glu Val Thr Asn Val
 625                 630                 635



      <210> 1313
      <211> 291
      <212> PRT
      <213> Homo sapiens


      <400> 1313
 Met Ser Met Pro Leu His Gln Ile Ser Ala Ile Pro Ser Gln Asp Ala
   1               5                  10                  15    
 Ile Ser Ala Arg Val Tyr Arg Ser Lys Thr Lys Glu Lys Glu Arg Glu
              20                  25                  30        
 Glu Gln Asn Glu Lys Thr Leu Gly His Phe Met Ser His Ser Ser Asn
          35                  40                  45            
 Ile Ser Lys Ala Gly Ser Pro Pro Ser Ala Ser Ala Pro Ala Pro Val
      50                  55                  60                
 Ser Ser Phe Ser Arg Thr Ser Ile Thr Pro Ser Ser Gln Asp Ile Cys
  65                  70                  75                  80
 Arg Ile Cys His Cys Glu Gly Asp Asp Glu Ser Pro Leu Ile Thr Pro
                  85                  90                  95    
 Cys His Cys Thr Gly Ser Leu His Phe Val His Gln Ala Cys Leu Gln
             100                 105                 110        
 Gln Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr
         115                 120                 125            
 Glu Phe Ile Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys
     130                 135                 140                
 Leu Gln Met Thr Ser Ser Glu Arg Arg Lys Ile Met Cys Ser Val Thr
 145                 150                 155                 160
 Phe His Val Ile Ala Ile Thr Cys Val Val Trp Ser Leu Tyr Val Leu
                 165                 170                 175    
 Ile Asp Arg Thr Ala Glu Glu Ile Lys Gln Gly Gln Ala Thr Gly Ile
             180                 185                 190        
 Leu Glu Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala Ile Gly Phe
         195                 200                 205            
 Thr Gly Gly Leu Leu Phe Met Tyr Val Gln Cys Lys Val Tyr Val Gln
     210                 215                 220                
 Leu Trp Lys Arg Leu Lys Ala Tyr Asn Arg Val Ile Tyr Val Gln Asn
 225                 230                 235                 240
 Cys Pro Glu Thr Ser Lys Lys Asn Ile Phe Glu Lys Ser Pro Leu Thr
                 245                 250                 255    
 Glu Pro Asn Phe Glu Asn Lys His Gly Tyr Gly Ile Cys His Ser Asp
             260                 265                 270        
 Thr Asn Ser Ser Cys Cys Thr Glu Pro Glu Asp Thr Gly Ala Glu Ile
         275                 280                 285            
 Ile His Val
     290    



      <210> 1314
      <211> 2309
      <212> PRT
      <213> Homo sapiens


      <400> 1314
 Met Pro Thr Ser Thr Ile Leu Arg Leu Leu Ala Glu Leu Val Arg Ser
   1               5                  10                  15    
 Tyr Val Gly Ile Ala Thr Leu Ile Ala Asn Tyr Ser Tyr Thr Val Gly
              20                  25                  30        
 Gln Ser Glu Leu Ile Lys Glu Asp Cys Ser Val Leu Ala Phe Val Leu
          35                  40                  45            
 Asp His Leu Leu Pro His Thr Gln Asn Ala Glu Asp Lys Asp Thr Pro
      50                  55                  60                
 Ala Leu Ala Arg Leu Phe Leu Ala Ser Leu Ala Ala Ala Gly Ser Gly
  65                  70                  75                  80
 Thr Asp Ala Gln Val Ala Leu Val Asn Glu Val Lys Ala Ala Leu Gly
                  85                  90                  95    
 Arg Ala Leu Ala Met Ala Glu Ser Thr Glu Lys His Ala Arg Leu Gln
             100                 105                 110        
 Ala Val Met Cys Ile Ile Ser Thr Ile Met Glu Ser Cys Pro Ser Thr
         115                 120                 125            
 Ser Ser Phe Tyr Ser Ser Ala Thr Ala Lys Thr Gln His Asn Gly Met
     130                 135                 140                
 Asn Asn Ile Ile Arg Leu Phe Leu Lys Lys Gly Leu Val Asn Asp Leu
 145                 150                 155                 160
 Ala Arg Val Pro His Ser Leu Asp Leu Ser Ser Pro Asn Met Ala Asn
                 165                 170                 175    
 Thr Val Asn Ala Ala Leu Lys Pro Leu Glu Thr Leu Ser Arg Ile Val
             180                 185                 190        
 Asn Gln Pro Ser Ser Leu Phe Gly Ser Lys Ser Ala Ser Ser Lys Asn
         195                 200                 205            
 Lys Ser Glu Gln Asp Ala Gln Gly Ala Ser Gln Asp Ser Ser Ser Asn
     210                 215                 220                
 Gln Gln Asp Pro Gly Glu Pro Gly Glu Ala Glu Val Gln Glu Glu Asp
 225                 230                 235                 240
 His Asp Val Thr Gln Thr Glu Val Ala Asp Gly Asp Ile Met Asp Gly
                 245                 250                 255    
 Glu Ala Glu Thr Asp Ser Val Val Ile Ala Gly Gln Pro Glu Val Leu
             260                 265                 270        
 Ser Ser Gln Glu Met Gln Val Glu Asn Glu Leu Glu Asp Leu Ile Asp
         275                 280                 285            
 Glu Leu Leu Glu Arg Asp Gly Gly Ser Gly Asn Ser Thr Ile Ile Val
     290                 295                 300                
 Ser Arg Ser Gly Glu Asp Glu Ser Gln Glu Asp Val Leu Met Asp Glu
 305                 310                 315                 320
 Ala Pro Ser Asn Leu Ser Gln Ala Ser Thr Leu Gln Ala Asn Arg Glu
                 325                 330                 335    
 Asp Ser Met Asn Ile Leu Asp Pro Glu Asp Glu Glu Glu His Thr Gln
             340                 345                 350        
 Glu Glu Asp Ser Ser Gly Ser Asn Glu Asp Glu Asp Asp Ser Gln Asp
         355                 360                 365            
 Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Asp Asp Gln Glu Asp Asp
     370                 375                 380                
 Glu Gly Glu Glu Gly Asp Glu Asp Asp Asp Asp Asp Gly Ser Glu Met
 385                 390                 395                 400
 Glu Leu Asp Glu Asp Tyr Pro Asp Met Asn Ala Ser Pro Leu Val Arg
                 405                 410                 415    
 Phe Glu Arg Phe Asp Arg Glu Asp Asp Leu Ile Ile Glu Phe Asp Asn
             420                 425                 430        
 Met Phe Ser Ser Ala Thr Asp Ile Pro Pro Ser Pro Gly Asn Ile Pro
         435                 440                 445            
 Thr Thr His Pro Leu Met Val Arg His Ala Asp His Ser Ser Leu Thr
     450                 455                 460                
 Leu Gly Ser Gly Ser Ser Thr Thr Arg Leu Thr Gln Gly Ile Gly Arg
 465                 470                 475                 480
 Ser Gln Arg Thr Leu Arg Gln Leu Thr Ala Asn Ala Gly His Thr Ile
                 485                 490                 495    
 His Val His Tyr Pro Gly Asn Arg Gln Pro Asn Pro Pro Leu Ile Leu
             500                 505                 510        
 Gln Arg Leu Leu Gly Pro Ser Ala Ala Ala Asp Ile Leu Gln Leu Ser
         515                 520                 525            
 Ser Ser Leu Pro Leu Gln Ser Arg Gly Arg Ala Arg Leu Leu Val Gly
     530                 535                 540                
 Asn Asp Asp Val His Ile Ile Ala Arg Ser Asp Asp Glu Leu Leu Asp
 545                 550                 555                 560
 Asp Phe Phe His Asp Gln Ser Thr Ala Thr Ser Gln Ala Gly Thr Leu
                 565                 570                 575    
 Ser Ser Ile Pro Thr Ala Leu Thr Arg Trp Thr Glu Glu Cys Lys Val
             580                 585                 590        
 Leu Asp Ala Glu Ser Met His Asp Cys Val Ser Val Val Lys Val Ser
         595                 600                 605            
 Ile Val Asn His Leu Glu Phe Leu Arg Asp Glu Glu Leu Glu Glu Arg
     610                 615                 620                
 Arg Glu Lys Arg Arg Lys Gln Leu Ala Glu Glu Glu Thr Lys Ile Thr
 625                 630                 635                 640
 Asp Lys Gly Lys Glu Asp Lys Glu Asn Arg Asp Gln Ser Ala Gln Cys
                 645                 650                 655    
 Thr Ala Ser Lys Ser Asn Asp Ser Thr Glu Gln Asn Leu Ser Asp Gly
             660                 665                 670        
 Thr Pro Met Pro Asp Ser Tyr Pro Thr Thr Pro Ser Ser Thr Asp Ala
         675                 680                 685            
 Ala Thr Ser Glu Ser Lys Glu Thr Leu Gly Thr Leu Gln Ser Ser Gln
     690                 695                 700                
 Gln Gln Pro Thr Leu Pro Thr Pro Pro Ala Leu Gly Glu Val Pro Gln
 705                 710                 715                 720
 Glu Leu Gln Ser Pro Ala Gly Glu Gly Gly Ser Ser Thr Gln Leu Leu
                 725                 730                 735    
 Met Pro Val Glu Pro Glu Glu Leu Gly Pro Thr Arg Pro Ser Gly Glu
             740                 745                 750        
 Ala Glu Thr Thr Gln Met Glu Leu Ser Pro Ala Pro Thr Ile Thr Ser
         755                 760                 765            
 Leu Ser Pro Glu Arg Ala Glu Asp Ser Asp Ala Leu Thr Ala Val Ser
     770                 775                 780                
 Ser Gln Leu Glu Gly Ser Pro Met Asp Thr Ser Ser Leu Ala Ser Cys
 785                 790                 795                 800
 Thr Leu Glu Glu Ala Val Gly Asp Thr Ser Ala Ala Gly Ser Ser Glu
                 805                 810                 815    
 Gln Pro Arg Ala Gly Ser Ser Thr Pro Gly Asp Ala Pro Pro Ala Val
             820                 825                 830        
 Ala Glu Val Gln Gly Arg Ser Asp Gly Ser Gly Glu Ser Ala Gln Pro
         835                 840                 845            
 Pro Glu Asp Ser Ser Pro Pro Ala Ser Ser Glu Ser Ser Ser Thr Arg
     850                 855                 860                
 Asp Ser Ala Val Ala Ile Ser Gly Ala Asp Ser Arg Gly Ile Leu Glu
 865                 870                 875                 880
 Glu Pro Leu Pro Ser Thr Ser Ser Glu Glu Glu Asp Pro Leu Ala Gly
                 885                 890                 895    
 Ile Ser Leu Pro Glu Gly Val Asp Pro Ser Phe Leu Ala Ala Leu Pro
             900                 905                 910        
 Asp Asp Ile Arg Arg Glu Val Leu Gln Asn Gln Leu Gly Ile Arg Pro
         915                 920                 925            
 Pro Thr Arg Thr Ala Pro Ser Thr Asn Ser Ser Ala Pro Ala Val Val
     930                 935                 940                
 Gly Asn Pro Gly Val Thr Glu Val Ser Pro Glu Phe Leu Ala Ala Leu
 945                 950                 955                 960
 Pro Pro Ala Ile Gln Glu Glu Val Leu Ala Gln Gln Arg Ala Glu Gln
                 965                 970                 975    
 Gln Arg Arg Glu Leu Ala Gln Asn Ala Ser Ser Asp Thr Pro Met Asp
             980                 985                 990        
 Pro Val Thr Phe Ile Gln Thr Leu Pro Ser Asp Leu Arg Arg Ser Val
         995                1000                1005            
 Leu Glu Asp Met Glu Asp Ser Val Leu Ala Val Met Pro Pro Asp Ile
    1010                1015                1020                
 Ala Ala Glu Ala Gln Ala Leu Arg Arg Glu Gln Glu Ala Arg Gln Arg
1025                1030                1035                1040
 Gln Leu Met His Glu Arg Leu Phe Gly His Ser Ser Thr Ser Ala Leu
                1045                1050                1055    
 Ser Ala Ile Leu Arg Ser Pro Ala Phe Thr Ser Arg Leu Ser Gly Asn
            1060                1065                1070        
 Arg Gly Val Gln Tyr Thr Arg Leu Ala Val Gln Arg Gly Gly Thr Phe
        1075                1080                1085            
 Gln Met Gly Gly Ser Ser Ser His Asn Arg Pro Ser Gly Ser Asn Val
    1090                1095                1100                
 Asp Thr Leu Leu Arg Leu Arg Gly Arg Leu Leu Leu Asp His Glu Ala
1105                1110                1115                1120
 Leu Ser Cys Leu Leu Val Leu Leu Phe Val Asp Glu Pro Lys Leu Asn
                1125                1130                1135    
 Thr Ser Arg Leu His Arg Val Leu Arg Asn Leu Cys Tyr His Ala Gln
            1140                1145                1150        
 Thr Arg His Trp Val Ile Arg Ser Leu Leu Ser Ile Leu Gln Arg Ser
        1155                1160                1165            
 Ser Glu Ser Glu Leu Cys Ile Glu Thr Pro Lys Leu Thr Thr Ser Glu
    1170                1175                1180                
 Glu Lys Gly Lys Lys Ser Ser Lys Ser Cys Gly Ser Ser Ser His Glu
1185                1190                1195                1200
 Asn Arg Pro Leu Asp Leu Leu His Lys Met Glu Ser Lys Ser Ser Asn
                1205                1210                1215    
 Gln Leu Ser Trp Leu Ser Val Ser Met Asp Ala Ala Leu Gly Cys Arg
            1220                1225                1230        
 Thr Asn Ile Phe Gln Ile Gln Arg Ser Gly Gly Arg Lys His Thr Glu
        1235                1240                1245            
 Lys His Ala Ser Gly Gly Ser Thr Val His Ile His Pro Gln Ala Ala
    1250                1255                1260                
 Pro Val Val Cys Arg His Val Leu Asp Thr Leu Ile Gln Leu Ala Lys
1265                1270                1275                1280
 Val Phe Pro Ser His Phe Thr Gln Gln Arg Thr Lys Glu Thr Asn Cys
                1285                1290                1295    
 Glu Ser Asp Arg Glu Arg Gly Asn Lys Ala Cys Ser Pro Cys Ser Ser
            1300                1305                1310        
 Gln Ser Ser Ser Ser Gly Ile Cys Thr Asp Phe Trp Asp Leu Leu Val
        1315                1320                1325            
 Lys Leu Asp Asn Met Asn Val Ser Arg Lys Gly Lys Asn Ser Val Lys
    1330                1335                1340                
 Ser Val Pro Val Ser Ala Gly Gly Glu Gly Glu Thr Ser Pro Tyr Ser
1345                1350                1355                1360
 Leu Glu Ala Ser Pro Leu Gly Gln Leu Met Asn Met Leu Ser His Pro
                1365                1370                1375    
 Val Ile Arg Arg Ser Ser Leu Leu Thr Glu Lys Leu Leu Arg Leu Leu
            1380                1385                1390        
 Ser Leu Ile Ser Ile Ala Leu Pro Glu Asn Lys Val Ser Glu Ala Gln
        1395                1400                1405            
 Ala Asn Ser Gly Ser Gly Ala Ser Ser Thr Thr Thr Ala Thr Ser Thr
    1410                1415                1420                
 Thr Ser Thr Thr Thr Thr Thr Ala Ala Ser Thr Thr Pro Thr Pro Pro
1425                1430                1435                1440
 Thr Ala Pro Thr Pro Val Thr Ser Ala Pro Ala Leu Val Ala Ala Thr
                1445                1450                1455    
 Ala Ile Ser Thr Ile Val Val Ala Ala Ser Thr Thr Val Thr Thr Pro
            1460                1465                1470        
 Thr Thr Ala Thr Thr Thr Val Ser Ile Ser Pro Thr Thr Lys Gly Ser
        1475                1480                1485            
 Lys Ser Pro Ala Lys Val Ser Asp Gly Gly Ser Ser Ser Thr Asp Phe
    1490                1495                1500                
 Lys Met Val Ser Ser Gly Leu Thr Glu Asn Gln Leu Gln Leu Ser Val
1505                1510                1515                1520
 Glu Val Leu Thr Ser His Ser Cys Ser Glu Glu Gly Leu Glu Asp Ala
                1525                1530                1535    
 Ala Asn Val Leu Leu Gln Leu Ser Arg Gly Asp Ser Gly Thr Arg Asp
            1540                1545                1550        
 Thr Val Leu Lys Leu Leu Leu Asn Gly Ala Arg His Leu Gly Tyr Thr
        1555                1560                1565            
 Leu Cys Lys Gln Ile Gly Thr Leu Leu Ala Glu Leu Arg Glu Tyr Asn
    1570                1575                1580                
 Leu Glu Gln Gln Arg Arg Ala Gln Cys Glu Thr Leu Ser Pro Asp Gly
1585                1590                1595                1600
 Leu Pro Glu Glu Gln Pro Gln Thr Thr Lys Leu Lys Gly Lys Met Gln
                1605                1610                1615    
 Ser Arg Phe Asp Met Ala Glu Asn Val Val Ile Val Ala Ser Gln Lys
            1620                1625                1630        
 Arg Pro Leu Gly Gly Arg Glu Leu Gln Leu Pro Ser Met Ser Met Leu
        1635                1640                1645            
 Thr Ser Lys Thr Ser Thr Gln Lys Phe Phe Leu Arg Val Leu Gln Val
    1650                1655                1660                
 Ile Ile Gln Leu Arg Asp Asp Thr Arg Arg Ala Asn Lys Lys Ala Lys
1665                1670                1675                1680
 Gln Thr Gly Arg Leu Gly Ser Ser Gly Leu Gly Ser Ala Ser Ser Ile
                1685                1690                1695    
 Gln Ala Ala Val Arg Gln Leu Glu Ala Glu Ala Asp Ala Ile Ile Gln
            1700                1705                1710        
 Met Val Arg Glu Gly Gln Arg Ala Arg Arg Gln Gln Gln Ala Ala Thr
        1715                1720                1725            
 Ser Glu Ser Ser Gln Ser Glu Ala Ser Val Arg Arg Glu Glu Ser Pro
    1730                1735                1740                
 Met Asp Val Asp Gln Pro Ser Pro Ser Ala Gln Asp Thr Gln Ser Ile
1745                1750                1755                1760
 Ala Ser Asp Gly Thr Pro Gln Gly Glu Lys Glu Lys Glu Glu Arg Pro
                1765                1770                1775    
 Pro Glu Leu Pro Leu Leu Ser Glu Gln Leu Ser Leu Asp Glu Leu Trp
            1780                1785                1790        
 Asp Met Leu Gly Glu Cys Leu Lys Glu Leu Glu Glu Ser His Asp Gln
        1795                1800                1805            
 His Ala Val Leu Val Leu Gln Pro Ala Val Glu Ala Phe Phe Leu Val
    1810                1815                1820                
 His Ala Thr Glu Arg Glu Ser Lys Pro Pro Val Arg Asp Thr Arg Glu
1825                1830                1835                1840
 Ser Gln Leu Ala His Ile Lys Asp Glu Pro Pro Pro Leu Ser Pro Ala
                1845                1850                1855    
 Pro Leu Thr Pro Ala Thr Pro Ser Ser Leu Asp Pro Phe Phe Ser Arg
            1860                1865                1870        
 Glu Pro Ser Ser Met His Ile Ser Ser Ser Leu Pro Pro Asp Thr Gln
        1875                1880                1885            
 Lys Phe Leu Arg Phe Ala Glu Thr His Arg Thr Val Leu Asn Gln Ile
    1890                1895                1900                
 Leu Arg Gln Ser Thr Thr His Leu Ala Asp Gly Pro Phe Ala Val Leu
1905                1910                1915                1920
 Val Asp Tyr Ile Arg Val Leu Asp Phe Asp Val Lys Arg Lys Tyr Phe
                1925                1930                1935    
 Arg Gln Glu Leu Glu Arg Leu Asp Glu Gly Leu Arg Lys Glu Asp Met
            1940                1945                1950        
 Ala Val His Val Arg Arg Asp His Val Phe Glu Asp Ser Tyr Arg Glu
        1955                1960                1965            
 Leu His Arg Lys Ser Pro Glu Glu Met Lys Asn Arg Leu Tyr Ile Val
    1970                1975                1980                
 Phe Glu Gly Glu Glu Gly Gln Asp Ala Gly Gly Leu Leu Arg Glu Trp
1985                1990                1995                2000
 Tyr Met Ile Ile Ser Arg Glu Met Phe Asn Pro Met Tyr Ala Leu Phe
                2005                2010                2015    
 Arg Thr Ser Pro Gly Asp Arg Val Thr Tyr Thr Ile Asn Pro Ser Ser
            2020                2025                2030        
 His Cys Asn Pro Asn His Leu Ser Tyr Phe Lys Phe Val Gly Arg Ile
        2035                2040                2045            
 Val Ala Lys Ala Val Tyr Asp Asn Arg Leu Leu Glu Cys Tyr Phe Thr
    2050                2055                2060                
 Arg Ser Phe Tyr Lys His Ile Leu Gly Lys Ser Val Arg Tyr Thr Asp
2065                2070                2075                2080
 Met Glu Ser Glu Asp Tyr His Phe Tyr Gln Gly Leu Val Tyr Leu Leu
                2085                2090                2095    
 Glu Asn Asp Val Ser Thr Leu Gly Tyr Asp Leu Thr Phe Ser Thr Glu
            2100                2105                2110        
 Val Gln Glu Phe Gly Val Cys Glu Val Arg Asp Leu Lys Pro Asn Gly
        2115                2120                2125            
 Ala Asn Ile Leu Val Thr Glu Glu Asn Lys Lys Glu Tyr Val His Leu
    2130                2135                2140                
 Val Cys Gln Met Arg Met Thr Gly Ala Ile Arg Lys Gln Leu Ala Ala
2145                2150                2155                2160
 Phe Leu Glu Gly Phe Tyr Glu Ile Ile Pro Lys Arg Leu Ile Ser Ile
                2165                2170                2175    
 Phe Thr Glu Gln Glu Leu Glu Leu Leu Ile Ser Gly Leu Pro Thr Ile
            2180                2185                2190        
 Asp Ile Asp Asp Leu Lys Ser Asn Thr Glu Tyr His Lys Tyr Gln Ser
        2195                2200                2205            
 Asn Ser Ile Gln Ile Gln Trp Phe Trp Arg Ala Leu Arg Ser Phe Asp
    2210                2215                2220                
 Gln Ala Asp Arg Ala Lys Phe Leu Gln Phe Val Thr Gly Thr Ser Lys
2225                2230                2235                2240
 Val Pro Leu Gln Gly Phe Ala Ala Leu Glu Gly Met Asn Gly Ile Gln
                2245                2250                2255    
 Lys Phe Gln Ile His Arg Asp Asp Arg Ser Thr Asp Arg Leu Pro Ser
            2260                2265                2270        
 Ala His Thr Cys Phe Asn Gln Leu Asp Leu Pro Ala Tyr Glu Ser Phe
        2275                2280                2285            
 Glu Lys Leu Arg His Met Leu Leu Leu Ala Ile Gln Glu Cys Ser Glu
    2290                2295                2300                
 Gly Phe Gly Leu Ala
2305                



      <210> 1315
      <211> 246
      <212> PRT
      <213> Homo sapiens


      <400> 1315
 Met Gly Lys Ala Ala Ala Ala Val Ala Phe Gly Ala Glu Val Gly Val
   1               5                  10                  15    
 Arg Leu Ala Leu Phe Ala Ala Phe Leu Val Thr Glu Leu Leu Pro Pro
              20                  25                  30        
 Phe Gln Arg Leu Ile Gln Pro Glu Glu Met Trp Leu Tyr Arg Asn Pro
          35                  40                  45            
 Tyr Val Glu Ala Glu Tyr Phe Pro Thr Lys Pro Met Phe Val Ile Ala
      50                  55                  60                
 Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala Lys Phe Leu Lys Lys
  65                  70                  75                  80
 Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu Ala Ala Ser Leu Ala
                  85                  90                  95    
 Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile Gly Leu Ala His Ser
             100                 105                 110        
 Asp Leu Met Cys Thr Gly Asp Lys Asp Val Val Asn Glu Gly Arg Lys
         115                 120                 125            
 Ser Phe Pro Ser Gly His Ser Ser Phe Ala Phe Ala Gly Leu Ala Phe
     130                 135                 140                
 Ala Ser Phe Tyr Leu Ala Gly Lys Leu His Cys Phe Thr Pro Gln Gly
 145                 150                 155                 160
 Arg Gly Lys Ser Trp Arg Phe Cys Ala Phe Leu Ser Pro Leu Leu Phe
                 165                 170                 175    
 Ala Ala Val Ile Ala Leu Ser Arg Thr Cys Asp Tyr Lys His His Trp
             180                 185                 190        
 Gln Asp Val Leu Val Gly Ser Met Ile Gly Met Thr Phe Ala Tyr Val
         195                 200                 205            
 Cys Tyr Arg Gln Tyr Tyr Pro Pro Leu Thr Asp Ala Glu Cys His Lys
     210                 215                 220                
 Pro Phe Gln Asp Lys Leu Val Leu Ser Thr Ala Gln Lys Pro Gly Asp
 225                 230                 235                 240
 Ser Tyr Cys Phe Asp Ile
                 245    



      <210> 1316
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 1316
 Met Gly Lys Ala Ala Ala Ala Val Ala Phe Gly Ala Glu Val Gly Val
   1               5                  10                  15    
 Arg Leu Ala Leu Phe Ala Ala Phe Leu Val Thr Glu Leu Leu Pro Pro
              20                  25                  30        
 Phe Gln Arg Leu Ile Gln Pro Glu Glu Met Trp Leu Tyr Arg Asn Pro
          35                  40                  45            
 Tyr Val Glu Ala Glu Tyr Phe Pro Thr Lys Pro Met Phe Val Ile Ala
      50                  55                  60                
 Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala Lys Phe Leu Lys Lys
  65                  70                  75                  80
 Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu Ala Ala Ser Leu Ala
                  85                  90                  95    
 Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile Lys Leu Ile Val Gly
             100                 105                 110        
 Arg Pro Arg Pro Asp Phe Phe Tyr Arg Cys Phe Pro Asp Gly Leu Ala
         115                 120                 125            
 His Ser Asp Leu Met Cys Thr Gly Asp Lys Asp Val Val Asn Glu Gly
     130                 135                 140                
 Arg Lys Ser Phe Pro Ser Gly His Ser Ser Phe Ala Phe Ala Gly Leu
 145                 150                 155                 160
 Ala Phe Ala Ser Phe Tyr Leu Ala Gly Lys Leu His Cys Phe Thr Pro
                 165                 170                 175    
 Gln Gly Arg Gly Lys Ser Trp Arg Phe Cys Ala Phe Leu Ser Pro Leu
             180                 185                 190        
 Leu Phe Ala Ala Val Ile Ala Leu Ser Arg Thr Cys Asp Tyr Lys His
         195                 200                 205            
 His Trp Gln Asp Val Leu Val Gly Ser Met Ile Gly Met Thr Phe Ala
     210                 215                 220                
 Tyr Val Cys Tyr Arg Gln Tyr Tyr Pro Pro Leu Thr Asp Ala Glu Cys
 225                 230                 235                 240
 His Lys Pro Phe Gln Asp Lys Leu Val Leu Ser Thr Thr Gln Lys Pro
                 245                 250                 255    
 Gly Asp Ser Tyr Cys Phe Asp Ile
             260                



      <210> 1317
      <211> 225
      <212> PRT
      <213> Homo sapiens


      <400> 1317
 Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu
   1               5                  10                  15    
 Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Glu Val Gln Gln Ser
              20                  25                  30        
 Pro His Cys Thr Thr Val Pro Val Gly Ala Ser Val Asn Ile Thr Cys
          35                  40                  45            
 Ser Thr Ser Gly Gly Leu Arg Gly Ile Tyr Leu Arg Gln Leu Gly Pro
      50                  55                  60                
 Gln Pro Gln Asp Ile Ile Tyr Tyr Glu Asp Gly Val Val Pro Thr Thr
  65                  70                  75                  80
 Asp Arg Arg Phe Arg Gly Arg Ile Asp Phe Ser Gly Ser Gln Asp Asn
                  85                  90                  95    
 Leu Thr Ile Thr Met His Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr
             100                 105                 110        
 Thr Cys Gln Ala Ile Thr Glu Val Asn Val Tyr Gly Ser Gly Thr Leu
         115                 120                 125            
 Val Leu Val Thr Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp
     130                 135                 140                
 Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Leu Pro Asp Pro Pro Ala
 145                 150                 155                 160
 Ala Ser Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly
                 165                 170                 175    
 Leu Gly Leu Gly Val Ala Cys Val Leu Ala Arg Thr Gln Ile Lys Lys
             180                 185                 190        
 Leu Cys Ser Trp Arg Asp Lys Asn Ser Ala Ala Cys Val Val Tyr Glu
         195                 200                 205            
 Asp Met Ser His Ser Arg Cys Asn Thr Leu Ser Ser Pro Asn Gln Tyr
     210                 215                 220                
 Gln
 225



      <210> 1318
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 1318
 Met Val Met Leu Ser Trp Gly Ala Val Arg His Ala Arg Glu Val Phe
   1               5                  10                  15    
 His Pro Tyr Asn Gly Arg Gln Cys Ser Ser Leu Leu Glu Thr Gly Lys
              20                  25                  30        
 Gly Gly Ser Val Pro Ala Lys Glu Leu Ser Arg Val His Thr Ala Phe
          35                  40                  45            
 Gln His Arg Val Ala Trp Leu Gln Ser Phe Arg Gly Arg Gly Gly Pro
      50                  55                  60                
 Ser Cys Arg Ser Trp Gly Ser Pro Gly Val Arg Thr Leu Gly Lys Pro
  65                  70                  75                  80
 Lys Ser Thr Arg Thr Leu Ala Ser Gly Glu Pro Asp His Met Arg Ser
                  85                  90                  95    
 Cys Pro Phe Leu Val Leu Leu Leu Thr Leu Asp Leu Gly Cys Arg Gln
             100                 105                 110        
 Ile Ser Glu Leu Ala Lys Ser Ala Ser Ser Trp Pro Val
         115                 120                 125



      <210> 1319
      <211> 461
      <212> PRT
      <213> Homo sapiens


      <400> 1319
 Met Lys Ile Leu Phe Val Glu Pro Ala Ile Phe Leu Ser Ala Phe Ala
   1               5                  10                  15    
 Met Thr Leu Thr Gly Pro Leu Thr Thr Gln Tyr Val Tyr Arg Arg Ile
              20                  25                  30        
 Trp Glu Glu Thr Gly Asn Tyr Thr Phe Ser Ser Asp Ser Asn Ile Ser
          35                  40                  45            
 Glu Cys Glu Lys Asn Lys Ser Ser Pro Ile Phe Ala Phe Gln Glu Glu
      50                  55                  60                
 Val Gln Lys Lys Val Ser Arg Phe Asn Leu Gln Met Asp Ile Ser Gly
  65                  70                  75                  80
 Leu Ile Pro Gly Leu Val Ser Thr Phe Ile Leu Leu Ser Ile Ser Asp
                  85                  90                  95    
 His Tyr Gly Arg Lys Phe Pro Met Ile Leu Ser Ser Val Gly Ala Leu
             100                 105                 110        
 Ala Thr Ser Val Trp Leu Cys Leu Leu Cys Tyr Phe Ala Phe Pro Phe
         115                 120                 125            
 Gln Leu Leu Ile Ala Ser Thr Phe Ile Gly Ala Phe Cys Gly Asn Tyr
     130                 135                 140                
 Thr Thr Phe Trp Gly Ala Cys Phe Ala Tyr Ile Val Asp Gln Cys Lys
 145                 150                 155                 160
 Glu His Lys Gln Lys Thr Ile Arg Ile Ala Ile Ile Asp Phe Leu Leu
                 165                 170                 175    
 Gly Leu Val Thr Gly Leu Thr Gly Leu Ser Ser Gly Tyr Phe Ile Arg
             180                 185                 190        
 Glu Leu Gly Phe Glu Trp Ser Phe Leu Ile Ile Ala Val Ser Leu Ala
         195                 200                 205            
 Val Asn Leu Ile Tyr Ile Leu Phe Phe Leu Gly Asp Pro Val Lys Glu
     210                 215                 220                
 Cys Ser Ser Gln Asn Val Thr Met Ser Cys Ser Glu Gly Phe Lys Asn
 225                 230                 235                 240
 Leu Phe Tyr Arg Thr Tyr Met Leu Phe Lys Asn Ala Ser Gly Lys Arg
                 245                 250                 255    
 Arg Phe Leu Leu Cys Leu Leu Leu Phe Thr Val Ile Thr Tyr Phe Phe
             260                 265                 270        
 Val Val Ile Gly Ile Ala Pro Ile Phe Ile Leu Tyr Glu Leu Asp Ser
         275                 280                 285            
 Pro Leu Cys Trp Asn Glu Val Phe Ile Gly Tyr Gly Ser Ala Leu Gly
     290                 295                 300                
 Ser Ala Ser Phe Leu Thr Ser Phe Leu Gly Ile Trp Leu Phe Ser Tyr
 305                 310                 315                 320
 Cys Met Glu Asp Ile His Met Ala Phe Ile Gly Ile Phe Thr Thr Met
                 325                 330                 335    
 Thr Gly Met Ala Met Thr Ala Phe Ala Ser Thr Thr Leu Met Met Phe
             340                 345                 350        
 Leu Ala Arg Val Pro Phe Leu Phe Thr Ile Val Pro Phe Ser Val Leu
         355                 360                 365            
 Arg Ser Met Leu Ser Lys Val Val Arg Ser Thr Glu Gln Gly Thr Leu
     370                 375                 380                
 Phe Ala Cys Ile Ala Phe Leu Glu Thr Leu Gly Gly Val Thr Ala Val
 385                 390                 395                 400
 Ser Thr Phe Asn Gly Ile Tyr Ser Ala Thr Val Ala Trp Tyr Pro Gly
                 405                 410                 415    
 Phe Thr Phe Leu Leu Ser Ala Gly Leu Leu Leu Leu Pro Ala Ile Ser
             420                 425                 430        
 Leu Cys Val Val Lys Cys Thr Ser Trp Asn Glu Gly Ser Tyr Glu Leu
         435                 440                 445            
 Leu Ile Gln Glu Glu Ser Ser Glu Asp Ala Ser Asp Arg
     450                 455                 460    



      <210> 1320
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 1320
 Met Lys Ile Leu Phe Val Glu Pro Ala Ile Phe Leu Ser Ala Phe Thr
   1               5                  10                  15    
 Met Thr Leu Thr Gly Pro Leu Thr Thr Gln Tyr Val Tyr Arg Arg Ile
              20                  25                  30        
 Trp Glu Glu Thr Gly Asn Tyr Thr Phe Ser Ser Asp Ser Asn Ile Ser
          35                  40                  45            
 Glu Cys Glu Lys Asn Lys Ser Ser Pro Ile Phe Ala Phe Gln Glu Val
      50                  55                  60                
 Arg Asn Tyr Asn Ile His Ser Ile
  65                  70        



      <210> 1321
      <211> 661
      <212> PRT
      <213> Homo sapiens


      <400> 1321
 Met Glu Gly Ala Arg Ala Arg Gly Ala Gln Leu Arg Leu Gly Glu Arg
   1               5                  10                  15    
 Val Arg Pro Val Gly Arg Arg Ser Ala Pro Gly Arg Ser Arg Phe His
              20                  25                  30        
 Gln Pro Trp Arg Pro Gly Ala Ser Asp Ser Ala Pro Pro Ala Gly Thr
          35                  40                  45            
 Met Ala Gln Ser Arg Val Leu Leu Leu Leu Leu Leu Leu Pro Pro Gln
      50                  55                  60                
 Leu His Leu Gly Pro Val Leu Ala Val Arg Ala Pro Gly Phe Gly Arg
  65                  70                  75                  80
 Ser Gly Gly His Ser Leu Ser Pro Glu Glu Asn Glu Phe Ala Glu Glu
                  85                  90                  95    
 Glu Pro Val Leu Val Leu Ser Pro Glu Glu Pro Gly Pro Gly Pro Ala
             100                 105                 110        
 Ala Val Ser Cys Pro Arg Asp Cys Ala Cys Ser Gln Glu Gly Val Val
         115                 120                 125            
 Asp Cys Gly Gly Ile Asp Leu Arg Glu Phe Pro Gly Asp Leu Pro Glu
     130                 135                 140                
 His Thr Asn His Leu Ser Leu Gln Asn Asn Gln Leu Glu Lys Ile Tyr
 145                 150                 155                 160
 Pro Glu Glu Leu Ser Arg Leu His Arg Leu Glu Thr Leu Asn Leu Gln
                 165                 170                 175    
 Asn Asn Arg Leu Thr Ser Arg Gly Leu Pro Glu Lys Ala Phe Glu His
             180                 185                 190        
 Leu Thr Asn Leu Asn Tyr Leu Tyr Leu Ala Asn Asn Lys Leu Thr Leu
         195                 200                 205            
 Ala Pro Arg Phe Leu Pro Asn Ala Leu Ile Ser Val Asp Phe Ala Ala
     210                 215                 220                
 Asn Tyr Leu Thr Lys Ile Tyr Gly Leu Thr Phe Gly Gln Lys Pro Asn
 225                 230                 235                 240
 Leu Arg Ser Val Tyr Leu His Asn Asn Lys Leu Ala Asp Ala Gly Leu
                 245                 250                 255    
 Pro Asp Asn Met Phe Asn Gly Ser Ser Asn Val Glu Val Leu Ile Leu
             260                 265                 270        
 Ser Ser Asn Phe Leu Arg His Val Pro Lys His Leu Pro Pro Ala Leu
         275                 280                 285            
 Tyr Lys Leu His Leu Lys Asn Asn Lys Leu Glu Lys Ile Pro Pro Gly
     290                 295                 300                
 Ala Phe Ser Glu Leu Ser Ser Leu Arg Glu Leu Tyr Leu Gln Asn Asn
 305                 310                 315                 320
 Tyr Leu Thr Asp Glu Gly Leu Asp Asn Glu Thr Phe Trp Lys Leu Ser
                 325                 330                 335    
 Ser Leu Glu Tyr Leu Asp Leu Ser Ser Asn Asn Leu Ser Arg Val Pro
             340                 345                 350        
 Ala Gly Leu Pro Arg Ser Leu Val Leu Leu His Leu Glu Lys Asn Ala
         355                 360                 365            
 Ile Arg Ser Val Asp Ala Asn Val Leu Thr Pro Ile Arg Ser Leu Glu
     370                 375                 380                
 Tyr Leu Leu Leu His Ser Asn Gln Leu Arg Glu Gln Gly Ile His Pro
 385                 390                 395                 400
 Leu Ala Phe Gln Gly Leu Lys Arg Leu His Thr Val His Leu Tyr Asn
                 405                 410                 415    
 Asn Ala Leu Glu Arg Val Pro Ser Gly Leu Pro Arg Arg Val Arg Thr
             420                 425                 430        
 Leu Met Ile Leu His Asn Gln Ile Thr Gly Ile Gly Arg Glu Asp Phe
         435                 440                 445            
 Ala Thr Thr Tyr Phe Leu Glu Glu Leu Asn Leu Ser Tyr Asn Arg Ile
     450                 455                 460                
 Thr Ser Pro Gln Val His Arg Asp Ala Phe Arg Lys Leu Arg Leu Leu
 465                 470                 475                 480
 Arg Ser Leu Asp Leu Ser Gly Asn Arg Leu His Thr Leu Pro Pro Gly
                 485                 490                 495    
 Leu Pro Arg Asn Val His Val Leu Lys Val Lys Arg Asn Glu Leu Ala
             500                 505                 510        
 Ala Leu Ala Arg Gly Ala Leu Ala Gly Met Ala Gln Leu Arg Glu Leu
         515                 520                 525            
 Tyr Leu Thr Ser Asn Arg Leu Arg Ser Arg Ala Leu Gly Pro Arg Ala
     530                 535                 540                
 Trp Val Asp Leu Ala His Leu Gln Leu Leu Asp Ile Ala Gly Asn Gln
 545                 550                 555                 560
 Leu Thr Glu Ile Pro Glu Gly Leu Pro Glu Ser Leu Glu Tyr Leu Tyr
                 565                 570                 575    
 Leu Gln Asn Asn Lys Ile Ser Ala Val Pro Ala Asn Ala Phe Asp Ser
             580                 585                 590        
 Thr Pro Asn Leu Lys Gly Ile Phe Leu Arg Phe Asn Lys Leu Ala Val
         595                 600                 605            
 Gly Ser Val Val Asp Ser Ala Phe Arg Arg Leu Lys His Leu Gln Val
     610                 615                 620                
 Leu Asp Ile Glu Gly Asn Leu Glu Phe Gly Asp Ile Ser Lys Asp Arg
 625                 630                 635                 640
 Gly Arg Leu Gly Lys Glu Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu
                 645                 650                 655    
 Glu Glu Glu Thr Arg
             660    



      <210> 1322
      <211> 396
      <212> PRT
      <213> Homo sapiens


      <400> 1322
 Met Leu Pro Leu Leu Leu Leu Pro Leu Leu Trp Gly Gly Ser Leu Gln
   1               5                  10                  15    
 Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln
              20                  25                  30        
 Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg
          35                  40                  45            
 Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly
      50                  55                  60                
 Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg
  65                  70                  75                  80
 Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val
                  85                  90                  95    
 Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp
             100                 105                 110        
 Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr
         115                 120                 125            
 Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu
     130                 135                 140                
 Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr
 145                 150                 155                 160
 Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu
                 165                 170                 175    
 Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr
             180                 185                 190        
 Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly
         195                 200                 205            
 Thr Asn Leu Thr Cys Gln Val Lys Arg Gln Gly Ala Gln Val Thr Thr
     210                 215                 220                
 Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Asn Leu Ala
 225                 230                 235                 240
 Ile Ser Ile Phe Phe Arg Asn Gly Thr Gly Thr Ala Leu Arg Ile Leu
                 245                 250                 255    
 Ser Asn Gly Met Ser Val Pro Ile Gln Glu Gly Gln Ser Leu Phe Leu
             260                 265                 270        
 Ala Cys Thr Val Asp Ser Asn Pro Pro Ala Ser Leu Ser Trp Phe Arg
         275                 280                 285            
 Glu Gly Lys Ala Leu Asn Pro Ser Gln Thr Ser Met Ser Gly Thr Leu
     290                 295                 300                
 Glu Leu Pro Asn Ile Gly Ala Arg Glu Gly Gly Glu Phe Thr Cys Arg
 305                 310                 315                 320
 Val Gln His Pro Leu Gly Ser Gln His Leu Ser Phe Ile Leu Ser Val
                 325                 330                 335    
 Gln Arg Ser Ser Ser Ser Cys Ile Cys Val Thr Glu Lys Gln Gln Gly
             340                 345                 350        
 Ser Trp Pro Leu Val Leu Thr Leu Ile Arg Gly Ala Leu Met Gly Ala
         355                 360                 365            
 Gly Phe Leu Leu Thr Tyr Gly Leu Thr Trp Ile Tyr Tyr Thr Arg Cys
     370                 375                 380                
 Gly Gly Pro Gln Gln Ser Arg Ala Glu Arg Pro Gly
 385                 390                 395    



      <210> 1323
      <211> 313
      <212> PRT
      <213> Homo sapiens


      <400> 1323
 Met Leu Pro Leu Leu Leu Leu Pro Leu Leu Trp Gly Gly Ser Leu Gln
   1               5                  10                  15    
 Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln
              20                  25                  30        
 Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg
          35                  40                  45            
 Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly
      50                  55                  60                
 Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Glu Arg
  65                  70                  75                  80
 Arg Val Lys Pro Gly Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val
                  85                  90                  95    
 Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp
             100                 105                 110        
 Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr
         115                 120                 125            
 Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Val Leu Ile Glu
     130                 135                 140                
 Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr
 145                 150                 155                 160
 Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu
                 165                 170                 175    
 Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr
             180                 185                 190        
 Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly
         195                 200                 205            
 Thr Asn Leu Thr Cys Gln Val Lys Arg Gln Gly Ala Gln Val Thr Thr
     210                 215                 220                
 Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Asn Leu Ala
 225                 230                 235                 240
 Ile Ser Ile Phe Phe Arg Asn Gly Thr Gly Thr Ala Leu Arg Ile Leu
                 245                 250                 255    
 Ser Asn Gly Met Ser Val Pro Ile Gln Glu Gly Gln Ser Leu Phe Leu
             260                 265                 270        
 Ala Cys Thr Val Asp Ser Asn Pro Pro Ala Ser Leu Ser Trp Phe Arg
         275                 280                 285            
 Glu Gly Lys Ala Leu Asn Pro Ser Gln Thr Ser Met Ser Arg Val Asp
     290                 295                 300                
 Asp Phe Val Arg Lys Gly Cys Lys Ile
 305                 310            



      <210> 1324
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 1324
 Met Glu Cys Cys Arg Arg Ala Thr Pro Gly Thr Leu Leu Leu Phe Leu
   1               5                  10                  15    
 Ala Phe Leu Leu Leu Ser Ser Arg Thr Ala Arg Ser Glu Glu Asp Arg
              20                  25                  30        
 Asp Gly Leu Trp Asp Ala Trp Gly Pro Trp Ser Glu Cys Ser Arg Thr
          35                  40                  45            
 Cys Gly Gly Gly Ala Ser Tyr Ser Leu Arg Arg Cys Leu Ser Ser Lys
      50                  55                  60                
 Ser Cys Glu Gly Arg Asn Ile Arg Tyr Arg Thr Cys Ser Asn Val Asp
  65                  70                  75                  80
 Cys Pro Pro Glu Ala Gly Asp Phe Arg Ala Gln Gln Cys Ser Ala His
                  85                  90                  95    
 Asn Asp Val Lys His His Gly Gln Phe Tyr Glu Trp Leu Pro Val Ser
             100                 105                 110        
 Asn Asp Pro Asp Asn Pro Cys Ser Leu Lys Cys Gln Ala Lys Gly Thr
         115                 120                 125            
 Thr Leu Val Val Glu Leu Ala Pro Lys Val Leu Asp Gly Thr Arg Cys
     130                 135                 140                
 Tyr Thr Glu Ser Leu Asp Met Cys Ile Ser Gly Leu Cys Gln Val Ser
 145                 150                 155                 160
 Ala Asp Leu Phe Ser Phe Asn Leu Ser Arg Gly Phe Gln Cys Leu Cys
                 165                 170                 175    
 Val Asn Gly Leu His Ser Leu Thr Leu
             180                 185



      <210> 1325
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 1325
 Met Gly Thr Gln Leu Leu Pro Ala Leu Cys Leu Val Leu Leu Val Leu
   1               5                  10                  15    
 Gly Phe Glu Val Gln Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro
              20                  25                  30        
 Ser Pro Thr Phe Leu Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp
          35                  40                  45            
 Glu Ser Ala Lys Thr Ala Ala Gln Asn Leu Cys Glu Lys Thr Tyr Leu
      50                  55                  60                
 Ser Ala Gly Asp Glu Lys Leu Arg Asp Ser Gly Ser Gly Thr Ala Ala
  65                  70                  75                  80
 Met Ser Thr Tyr Thr Gly Leu Phe Thr Gly Gln Val Leu Ser Val Leu
                  85                  90                  95    
 Lys Gly Glu Glu
             100



      <210> 1326
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 1326
 Met Gly Thr Gln Leu Leu Pro Ala Leu Cys Leu Val Leu Leu Val Leu
   1               5                  10                  15    
 Gly Phe Glu Val Gln Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro
              20                  25                  30        
 Ser Pro Thr Phe Leu Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp
          35                  40                  45            
 Glu Ser Ala Lys Thr Ala Ala Gln Asn Leu Cys Glu Lys Thr Tyr Leu
      50                  55                  60                
 Ser Ala Gly Asp Glu Lys Leu Arg Asp Ser Gly Ser Gly Thr Ala Ala
  65                  70                  75                  80
 Met Ser Thr Tyr Thr Gly Leu Phe Thr Gly Gln Val Leu Ser Val Leu
                  85                  90                  95    
 Lys Gly Glu Glu Leu Gln Ala Asp Pro Pro Ser Val Asp Gly Glu Ser
             100                 105                 110        
 Ala Leu Leu Pro
         115    



      <210> 1327
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 1327
 Met Leu Leu Ala His Arg Thr Leu His Cys Cys Phe Trp Gly Lys Gly
   1               5                  10                  15    
 His Met Ser Leu Ile Glu Cys Leu Gln Ser Trp Ile Asp Val Glu Lys
              20                  25                  30        
 Thr Pro Phe Pro Ser Ser Phe Glu Arg Leu Pro Leu Gly Ser Gln Glu
          35                  40                  45            
 Glu Gly Phe Pro Asp Phe Asp Thr His Gly His Leu Gly Thr Lys Ala
      50                  55                  60                
 Leu Trp Tyr Arg Lys Thr Asn Leu Phe Leu Cys Pro Leu Leu Pro Phe
  65                  70                  75                  80
 His Leu Ser Ala
                



      <210> 1328
      <211> 754
      <212> PRT
      <213> Homo sapiens


      <400> 1328
 Met Arg Val Leu Ala Cys Leu Leu Glu Arg Leu Arg Leu Ala Asp Gly
   1               5                  10                  15    
 Pro His Gly Cys Ala Gly Arg Leu Glu Val Trp His Gly Gly Arg Trp
              20                  25                  30        
 Gly Thr Val Cys Asp Asp Gly Trp Asp Leu Arg Asp Ala Ala Val Ala
          35                  40                  45            
 Cys Arg Gln Leu Gly Cys Gly Gly Ala Leu Ala Ala Pro Gly Gly Ala
      50                  55                  60                
 Phe Phe Gly Glu Gly Ala Gly Pro Val Trp Leu Ser Glu Leu Ala Cys
  65                  70                  75                  80
 Arg Gly Asn Glu Gly Gln Leu Gly Leu Cys His His Arg Gly Trp Lys
                  85                  90                  95    
 Ala His Ile Cys Ser His Glu Glu Asp Ala Gly Val Val Cys Ala Gly
             100                 105                 110        
 Gln Arg Val Ala Asn Ser Arg Asp Asp Ser Thr Ser Pro Leu Asp Gly
         115                 120                 125            
 Ala Pro Trp Pro Gly Leu Leu Leu Glu Leu Ser Pro Ser Thr Glu Glu
     130                 135                 140                
 Pro Leu Val Thr His Ala Gly Asn Pro Gln Asn Ala Ser Arg Lys Lys
 145                 150                 155                 160
 Ser Pro Arg Pro Lys Gln Ala Lys Ser Thr Arg Ala Pro Leu Leu Thr
                 165                 170                 175    
 Thr Gly Ala Pro Arg Gln Glu Arg Leu Arg Leu Val Ser Gly Pro His
             180                 185                 190        
 Arg Cys Ala Gly Arg Leu Glu Val Trp His Gly Gly Arg Trp Gly Thr
         195                 200                 205            
 Val Cys Asp Asp Gly Trp Asp Leu Arg Asp Ala Ala Val Ala Cys Arg
     210                 215                 220                
 Glu Leu Gly Cys Gly Gly Ala Leu Ala Ala Pro Gly Gly Ala Arg Phe
 225                 230                 235                 240
 Gly Pro Gly Ala Gly Pro Val Trp Met Asp Asp Val Gly Cys Gly Gly
                 245                 250                 255    
 Gly Glu Gln Ala Leu Arg Asp Cys Pro Arg Ser Pro Trp Gly Arg Ser
             260                 265                 270        
 Asn Cys Asp His Ser Glu Asp Ala Gly Leu Val Cys Thr Asp Glu Glu
         275                 280                 285            
 Lys Gln Thr Gly Pro Ala Pro Arg Leu Arg Leu Ala Asp Gly Pro His
     290                 295                 300                
 Gly Cys Ala Gly Arg Leu Glu Val Trp His Gly Gly Arg Trp Gly Ser
 305                 310                 315                 320
 Val Cys Asp Asp Ala Trp Asp Leu Arg Asp Ala Ala Val Ala Cys Arg
                 325                 330                 335    
 Glu Leu Gly Cys Gly Gly Ala Leu Ala Ala Pro Gly Gly Ala Phe Phe
             340                 345                 350        
 Gly Glu Gly Ser Gly Pro Ile Ile Leu Asp Asp Leu Arg Cys Arg Gly
         355                 360                 365            
 Asn Glu Thr Ala Leu Arg Phe Cys Pro Ala Arg Pro Trp Gly Gln His
     370                 375                 380                
 Asp Cys His His Arg Glu Asp Ala Gly Ala Val Cys Asp Gly Ser Pro
 385                 390                 395                 400
 Gln Leu Arg Leu Val Ala Gly Pro Ser Lys Cys Ser Gly Arg Leu Glu
                 405                 410                 415    
 Val Trp His Asp Gln Arg Trp Gly Thr Val Cys Asp Asp Ser Trp Asp
             420                 425                 430        
 Met Arg Asp Ser Ala Val Val Cys Arg Glu Leu Gly Cys Gly Gly Pro
         435                 440                 445            
 Gln Gln Pro Asp Pro Ala Ala Gly Arg Phe Gly Trp Gly Ala Gly Pro
     450                 455                 460                
 Ile Trp Leu Asp Asp Val Gly Cys Val Gly Thr Glu Ala Ser Leu Ser
 465                 470                 475                 480
 Asp Cys Pro Ala Ala Pro Trp Gly Lys His Asn Cys Ala His Asn Glu
                 485                 490                 495    
 Asp Val Gly Val Thr Cys Thr Gly Pro Pro Gly Leu Asp Ser Ile Ser
             500                 505                 510        
 Asp Pro Phe Ser Trp Ser Trp Ile Pro Gly Leu Gly Arg Asp Arg Asp
         515                 520                 525            
 Ala Trp Leu Pro Gly Glu Leu Ala Thr Lys Pro Ser Ala Ser Val Thr
     530                 535                 540                
 Ala Ser Val Leu Glu Lys Thr Thr Thr Lys Ala Pro Gly Lys Met Pro
 545                 550                 555                 560
 Lys Ser Thr Lys Lys Trp Ala Pro Arg Glu Arg Thr Thr Lys Thr Met
                 565                 570                 575    
 Ala Met Leu Thr Thr Gln Gly Pro Gln Glu Met Thr Ser Glu Ser Thr
             580                 585                 590        
 Ile Lys Ser Ile Pro Gln Ala Ser Leu Glu Pro Ser Ala Glu Ile Pro
         595                 600                 605            
 Glu Gly Ser Pro Glu Ser Pro Lys Asp Pro Ala Pro Ser Pro Ser Val
     610                 615                 620                
 Ser Thr Thr Gly Glu Ser Gly Leu Phe Arg Val Arg Leu Ala Asp Gly
 625                 630                 635                 640
 Pro Asn Arg Cys Ala Gly Arg Leu Glu Val Trp His Ala Gly Arg Trp
                 645                 650                 655    
 Gly Thr Val Cys Asp Asp Asn Trp Asp Leu Arg Asp Ala Thr Val Ala
             660                 665                 670        
 Cys Trp Glu Leu Gly Cys Gly Lys Val Arg Pro Arg Val Gly Lys Thr
         675                 680                 685            
 His Tyr Gly Pro Gly Thr Gly Pro Ile Trp Leu Asp Asp Met Gly Cys
     690                 695                 700                
 Lys Gly Ser Glu Ala Ser Leu Ser Asp Cys Pro Ser Gly Ala Trp Gly
 705                 710                 715                 720
 Lys His Asn Cys Asp His Glu Glu Asp Ser Arg Lys Arg Glu Leu Arg
                 725                 730                 735    
 Glu Val Met Leu Leu Val Gln Gly Leu Pro Gly Leu Gln Arg Leu Pro
             740                 745                 750        
 Ser Pro
        



      <210> 1329
      <211> 189
      <212> PRT
      <213> Homo sapiens


      <400> 1329
 Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln
   1               5                  10                  15    
 Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asp Pro Pro Trp Ser
              20                  25                  30        
 Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser
          35                  40                  45            
 His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu
      50                  55                  60                
 Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr
  65                  70                  75                  80
 Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu
                  85                  90                  95    
 Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu
             100                 105                 110        
 Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr
         115                 120                 125            
 His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr
     130                 135                 140                
 Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys
 145                 150                 155                 160
 Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val
                 165                 170                 175    
 Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Gly Asn Gly
             180                 185                



      <210> 1330
      <211> 220
      <212> PRT
      <213> Homo sapiens


      <400> 1330
 Met Arg Ser Ser Leu Thr Met Val Gly Thr Leu Trp Ala Phe Leu Ser
   1               5                  10                  15    
 Leu Val Thr Ala Val Thr Ser Ser Thr Ser Tyr Phe Leu Pro Tyr Trp
              20                  25                  30        
 Leu Phe Gly Ser Gln Met Gly Lys Pro Val Ser Phe Ser Thr Phe Arg
          35                  40                  45            
 Arg Cys Asn Tyr Pro Val Arg Gly Glu Gly His Ser Leu Ile Met Val
      50                  55                  60                
 Glu Glu Cys Gly Arg Tyr Ala Ser Phe Asn Ala Ile Pro Ser Leu Ala
  65                  70                  75                  80
 Trp Gln Met Cys Thr Val Val Thr Gly Ala Gly Cys Ala Leu Leu Leu
                  85                  90                  95    
 Leu Val Ala Leu Ala Ala Val Leu Gly Cys Cys Met Glu Glu Leu Ile
             100                 105                 110        
 Ser Arg Met Met Gly Arg Cys Met Gly Ala Ala Gln Phe Val Gly Gly
         115                 120                 125            
 Leu Leu Ile Ser Ser Gly Cys Ala Leu Tyr Pro Leu Gly Trp Asn Ser
     130                 135                 140                
 Pro Glu Ile Met Gln Thr Cys Gly Asn Val Ser Asn Gln Phe Gln Leu
 145                 150                 155                 160
 Gly Thr Cys Arg Leu Gly Trp Ala Tyr Tyr Cys Ala Gly Gly Gly Ala
                 165                 170                 175    
 Ala Ala Ala Met Leu Ile Cys Thr Trp Leu Ser Cys Phe Ala Gly Arg
             180                 185                 190        
 Asn Pro Lys Pro Val Ile Leu Val Glu Ser Ile Met Arg Asn Thr Asn
         195                 200                 205            
 Ser Tyr Ala Met Glu Leu Asp His Cys Leu Lys Pro
     210                 215                 220



      <210> 1331
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 1331
 Met Ala Lys Phe Leu Ser Gln Asp Gln Ile Asn Glu Tyr Lys Glu Cys
   1               5                  10                  15    
 Phe Ser Leu Tyr Asp Lys Gln Gln Arg Gly Lys Ile Lys Ala Thr Asp
              20                  25                  30        
 Leu Leu Val Ser Met Arg Cys Leu Gly Ala Ser Pro Thr Pro Gly Glu
          35                  40                  45            
 Val Gln Arg His Leu Gln Thr His Gly Ile Asp Lys Asn Gly Glu Leu
      50                  55                  60                
 Asp Phe Ser Thr Phe Leu Thr Ile Met His Met Gln Ile Lys Gln Glu
  65                  70                  75                  80
 Asp Pro Lys Lys Glu Ile Leu Leu Ala Met Leu Met Ala Asp Lys Glu
                  85                  90                  95    
 Lys Lys Gly Tyr Ile Met Ala Ser Glu Leu Arg Ser Lys Leu Met Lys
             100                 105                 110        
 Leu Gly Glu Lys Leu Thr His Lys Glu Val Asp Asp Leu Phe Lys Glu
         115                 120                 125            
 Ala Gly Ile Glu Pro Asn Gly Gln Val Lys Tyr Asp Thr Phe Ile Gln
     130                 135                 140                
 Arg Ile Thr Ile Pro Val Arg Asp Tyr
 145                 150            



      <210> 1332
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 1332
 Met Lys Lys Asn Arg Glu Arg Phe Cys Asn Lys Glu Arg Glu Phe Val
   1               5                  10                  15    
 Tyr Lys Phe Gln Val Gly Arg Glu Arg Leu Glu Leu Arg Val Pro Leu
              20                  25                  30        
 Arg Phe Pro Val Glu Glu Asn Ala Ser His Leu His Gly Arg Leu Met
          35                  40                  45            
 Leu Leu His Ser Leu Pro Cys Phe Ile Glu Ser Asp Leu Lys Asp Ala
      50                  55                  60                
 Leu Ser Arg Phe Ile Glu Glu Glu Ser Leu Arg Asp His Asp Ser Asp
  65                  70                  75                  80
 Ala Glu Ala Cys Leu Glu Ala Val Lys Ser Gly Glu Val Asp Leu His
                  85                  90                  95    
 Gln Leu Ala Ser Ala Trp Ala Lys Ala Tyr Ala Glu Thr Thr Leu Glu
             100                 105                 110        
 His Ala Arg Pro Glu Glu Pro Asp Trp Asp Glu Asp Phe Ala Asp Val
         115                 120                 125            
 Tyr His Asp Leu Ile His Ser Pro Ala Ser Glu Thr Leu Leu Asn Leu
     130                 135                 140                
 Glu His Asn Tyr Phe Val Ser Ile Ser Glu Leu Ile Gly Glu Arg Asp
 145                 150                 155                 160
 Val Glu Leu Lys Lys Leu Arg Glu Arg Gln Gly Ile Glu Met Glu Lys
                 165                 170                 175    
 Val Met Gln Glu His Gln Thr Ser Met Gln Met Thr Gly Ile Leu Leu
             180                 185                 190        
 His Arg Lys Pro Glu Gly His Ser Gln Leu
         195                 200        



      <210> 1333
      <211> 365
      <212> PRT
      <213> Homo sapiens


      <400> 1333
 Met Leu Pro Pro Leu Pro Ser Arg Leu Gly Leu Leu Leu Leu Leu Leu
   1               5                  10                  15    
 Leu Cys Pro Ala His Val Gly Gly Leu Trp Trp Ala Val Gly Ser Pro
              20                  25                  30        
 Leu Val Met Asp Pro Thr Ser Ile Cys Arg Lys Ala Arg Arg Leu Ala
          35                  40                  45            
 Gly Arg Gln Ala Glu Leu Cys Gln Ala Glu Pro Glu Val Val Ala Glu
      50                  55                  60                
 Leu Ala Arg Gly Ala Arg Leu Gly Val Arg Glu Cys Gln Phe Gln Phe
  65                  70                  75                  80
 Arg Phe Arg Arg Trp Asn Cys Ser Ser His Ser Lys Ala Phe Gly Arg
                  85                  90                  95    
 Ile Leu Gln Gln Asp Ile Arg Glu Thr Ala Phe Val Phe Ala Ile Thr
             100                 105                 110        
 Ala Ala Gly Ala Ser His Ala Val Thr Gln Ala Cys Ser Met Gly Glu
         115                 120                 125            
 Leu Leu Gln Cys Gly Cys Gln Ala Pro Arg Gly Arg Ala Pro Pro Arg
     130                 135                 140                
 Pro Ser Gly Leu Pro Gly Thr Pro Gly Pro Pro Gly Pro Ala Gly Ser
 145                 150                 155                 160
 Pro Glu Gly Ser Ala Ala Trp Glu Trp Gly Gly Cys Gly Asp Asp Val
                 165                 170                 175    
 Asp Phe Gly Asp Glu Lys Ser Arg Leu Phe Met Asp Ala Arg His Lys
             180                 185                 190        
 Arg Gly Arg Gly Asp Ile Arg Ala Leu Val Gln Leu His Asn Asn Glu
         195                 200                 205            
 Ala Gly Arg Leu Ala Val Arg Ser His Thr Arg Thr Glu Cys Lys Cys
     210                 215                 220                
 His Gly Leu Ser Gly Ser Cys Ala Leu Arg Thr Cys Trp Gln Lys Leu
 225                 230                 235                 240
 Pro Pro Phe Arg Glu Val Gly Ala Arg Leu Leu Glu Arg Phe His Gly
                 245                 250                 255    
 Ala Ser Arg Val Met Gly Thr Asn Asp Gly Lys Ala Leu Leu Pro Ala
             260                 265                 270        
 Val Arg Thr Leu Lys Pro Pro Gly Arg Ala Asp Leu Leu Tyr Ala Ala
         275                 280                 285            
 Asp Ser Pro Asp Phe Cys Ala Pro Asn Arg Arg Thr Gly Ser Pro Gly
     290                 295                 300                
 Thr Arg Gly Arg Ala Cys Asn Ser Ser Ala Pro Asp Leu Ser Gly Cys
 305                 310                 315                 320
 Asp Leu Leu Cys Cys Gly Arg Gly His Arg Gln Glu Ser Val Gln Leu
                 325                 330                 335    
 Glu Glu Asn Cys Leu Cys Arg Phe His Trp Cys Cys Val Val Gln Cys
             340                 345                 350        
 His Arg Cys Arg Val Arg Lys Glu Leu Ser Leu Cys Leu
         355                 360                 365



      <210> 1334
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 1334
 Met Glu Glu Lys Tyr Gly Gly Asp Val Leu Ala Gly Pro Arg Gly Gly
   1               5                  10                  15    
 Gly Gly Leu Gly Pro Val Asp Val Pro Ser Ala Arg Leu Thr Lys Tyr
              20                  25                  30        
 Ile Val Leu Leu Cys Phe Thr Lys Phe Leu Lys Ala Val Gly Leu Phe
          35                  40                  45            
 Glu Ser Tyr Asp Leu Leu Lys Ala Val His Ile Val Gln Phe Ile Phe
      50                  55                  60                
 Ile Leu Lys Leu Gly Thr Ala Phe Phe Met Val Leu Phe Gln Lys Pro
  65                  70                  75                  80
 Phe Ser Ser Gly Lys Thr Ile Thr Lys His Gln Ile Ile Gly Ser Leu
                  85                  90                  95    
 Lys Ile Pro Gly Arg Lys Glu Phe Lys Asp Lys Lys Leu Asn Asp Pro
             100                 105                 110        
 Arg Lys Leu Val Gly Asn
         115            



      <210> 1335
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 1335
 Met Cys Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala Ile
   1               5                  10                  15    
 Ser Pro Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn
              20                  25                  30        
 Leu Ser Leu Pro Asp Ile Gly Phe Thr Ser Thr Thr Val Pro Lys Met
          35                  40                  45            
 Ile Val Asp Ile Gln Ser His Ser Arg Val Ile Ser Tyr Ala Gly Cys
      50                  55                  60                
 Leu Thr Gln Met Ser Leu Phe Ala Ile Phe Gly Gly Met Glu Glu Arg
  65                  70                  75                  80
 His Ala Pro Glu Cys Asp Gly Leu
                  85            



      <210> 1336
      <211> 628
      <212> PRT
      <213> Homo sapiens


      <400> 1336
 Met Ala Glu Leu Gly Glu Leu Lys His Met Val Met Ser Phe Arg Val
   1               5                  10                  15    
 Ser Glu Leu Gln Val Leu Leu Gly Phe Ala Gly Arg Asn Lys Ser Gly
              20                  25                  30        
 Arg Lys His Glu Leu Leu Ala Lys Ala Leu His Leu Leu Lys Ser Ser
          35                  40                  45            
 Cys Ala Pro Ser Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg
      50                  55                  60                
 Phe Pro Arg Lys Thr Leu Gly Pro Ser Asp Leu Ser Leu Leu Ser Leu
  65                  70                  75                  80
 Pro Pro Gly Thr Ser Pro Val Gly Ser Pro Gly Pro Leu Ala Pro Ile
                  85                  90                  95    
 Pro Pro Thr Leu Leu Ala Pro Gly Thr Leu Leu Gly Pro Lys Arg Glu
             100                 105                 110        
 Val Asp Met His Pro Pro Leu Pro Gln Pro Val His Pro Asp Val Thr
         115                 120                 125            
 Met Lys Pro Leu Pro Phe Tyr Glu Val Tyr Gly Glu Leu Ile Arg Pro
     130                 135                 140                
 Thr Thr Leu Ala Ser Thr Ser Ser Gln Arg Phe Glu Glu Ala His Phe
 145                 150                 155                 160
 Thr Phe Ala Leu Thr Pro Gln Gln Val Gln Gln Ile Leu Thr Ser Arg
                 165                 170                 175    
 Glu Val Leu Pro Gly Ala Lys Cys Asp Tyr Thr Ile Gln Val Gln Leu
             180                 185                 190        
 Arg Phe Cys Leu Cys Glu Thr Ser Cys Pro Gln Glu Asp Tyr Phe Pro
         195                 200                 205            
 Pro Asn Leu Phe Val Lys Val Asn Gly Lys Leu Cys Pro Leu Pro Gly
     210                 215                 220                
 Tyr Leu Pro Pro Thr Lys Asn Gly Ala Glu Pro Lys Arg Pro Ser Arg
 225                 230                 235                 240
 Pro Ile Asn Ile Thr Pro Leu Ala Arg Leu Ser Ala Thr Val Pro Asn
                 245                 250                 255    
 Thr Ile Val Val Asn Trp Ser Ser Glu Phe Gly Arg Asn Tyr Ser Leu
             260                 265                 270        
 Ser Val Tyr Leu Val Arg Gln Leu Thr Ala Gly Thr Leu Leu Gln Lys
         275                 280                 285            
 Leu Arg Ala Lys Gly Ile Arg Asn Pro Asp His Ser Arg Ala Leu Ile
     290                 295                 300                
 Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Val Ala Thr Thr Ser
 305                 310                 315                 320
 Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met Arg Leu Thr Val
                 325                 330                 335    
 Pro Cys Arg Ala Leu Thr Cys Ala His Leu Gln Ser Phe Asp Ala Ala
             340                 345                 350        
 Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Thr Cys Pro Val
         355                 360                 365            
 Cys Asp Lys Lys Ala Pro Tyr Glu Ser Leu Ile Ile Asp Gly Leu Phe
     370                 375                 380                
 Met Glu Ile Leu Ser Ser Cys Ser Asp Cys Asp Glu Ile Gln Phe Met
 385                 390                 395                 400
 Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys Lys Glu Ala Ser Glu
                 405                 410                 415    
 Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly Leu Gln Tyr Ser Pro
             420                 425                 430        
 Val Gln Gly Gly Asp Pro Ser Glu Asn Lys Lys Lys Val Glu Val Ile
         435                 440                 445            
 Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Asp Leu Pro Pro Thr
     450                 455                 460                
 Lys Lys His Cys Ser Val Thr Ser Ala Ala Ile Pro Ala Leu Pro Gly
 465                 470                 475                 480
 Ser Lys Gly Val Leu Thr Ser Gly His Gln Pro Ser Ser Val Leu Arg
                 485                 490                 495    
 Ser Pro Ala Met Gly Thr Leu Gly Gly Asp Phe Leu Ser Ser Leu Pro
             500                 505                 510        
 Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly Ala Asp Ile Gln Gly
         515                 520                 525            
 Leu Asp Leu Phe Ser Phe Leu Gln Thr Glu Ser Gln His Tyr Gly Pro
     530                 535                 540                
 Ser Val Ile Thr Ser Leu Asp Glu Gln Asp Ala Leu Gly His Phe Phe
 545                 550                 555                 560
 Gln Tyr Arg Gly Thr Pro Ser His Phe Leu Gly Pro Leu Ala Pro Thr
                 565                 570                 575    
 Leu Gly Ser Ser His Cys Ser Ala Thr Pro Ala Pro Pro Pro Gly Arg
             580                 585                 590        
 Val Ser Ser Ile Val Ala Pro Gly Gly Ala Leu Arg Glu Gly His Gly
         595                 600                 605            
 Gly Pro Leu Pro Ser Gly Pro Ser Leu Thr Gly Cys Arg Ser Asp Ile
     610                 615                 620                
 Ile Ser Leu Asp
 625            



      <210> 1337
      <211> 330
      <212> PRT
      <213> Homo sapiens


      <400> 1337
 Met Pro Gly Pro Ala Thr Asp Ala Gly Lys Ile Pro Phe Cys Asp Ala
   1               5                  10                  15    
 Lys Glu Glu Ile Arg Ala Gly Leu Glu Ser Ser Glu Gly Gly Gly Gly
              20                  25                  30        
 Pro Glu Arg Pro Gly Ala Arg Gly Gln Arg Gln Asn Ile Val Trp Arg
          35                  40                  45            
 Asn Val Val Leu Met Ser Leu Leu His Leu Gly Ala Val Tyr Ser Leu
      50                  55                  60                
 Val Leu Ile Pro Lys Ala Lys Pro Leu Thr Leu Leu Trp Ala Tyr Phe
  65                  70                  75                  80
 Cys Phe Leu Leu Ala Ala Leu Gly Val Thr Ala Gly Ala His Arg Leu
                  85                  90                  95    
 Trp Ser His Arg Ser Tyr Arg Ala Lys Leu Pro Leu Arg Ile Phe Leu
             100                 105                 110        
 Ala Val Ala Asn Ser Met Ala Phe Gln Asn Asp Ile Phe Glu Trp Ser
         115                 120                 125            
 Arg Asp His Arg Ala His His Lys Tyr Ser Glu Thr Asp Ala Asp Pro
     130                 135                 140                
 His Asn Ala Arg Arg Gly Phe Phe Phe Ser His Ile Gly Trp Leu Phe
 145                 150                 155                 160
 Val Arg Lys His Arg Asp Val Ile Glu Lys Gly Arg Lys Leu Asp Val
                 165                 170                 175    
 Thr Asp Leu Leu Ala Asp Pro Val Val Arg Ile Gln Arg Lys Tyr Tyr
             180                 185                 190        
 Lys Ile Ser Val Val Leu Met Cys Phe Val Val Pro Thr Leu Val Pro
         195                 200                 205            
 Trp Tyr Ile Trp Gly Glu Ser Leu Trp Asn Ser Tyr Phe Leu Ala Ser
     210                 215                 220                
 Ile Leu Arg Tyr Thr Ile Ser Leu Asn Ile Ser Trp Leu Val Asn Ser
 225                 230                 235                 240
 Ala Ala His Met Tyr Gly Asn Arg Pro Tyr Asp Lys His Ile Ser Pro
                 245                 250                 255    
 Arg Gln Asn Pro Leu Val Ala Leu Gly Ala Ile Gly Glu Gly Phe His
             260                 265                 270        
 Asn Tyr His His Thr Phe Pro Phe Asp Tyr Ser Ala Ser Glu Phe Gly
         275                 280                 285            
 Leu Asn Phe Asn Pro Thr Thr Trp Phe Ile Asp Phe Met Cys Trp Leu
     290                 295                 300                
 Gly Leu Ala Thr Asp Arg Lys Arg Ala Thr Lys Pro Met Ile Glu Ala
 305                 310                 315                 320
 Arg Lys Ala Arg Thr Gly Asp Ser Ser Ala
                 325                 330



      <210> 1338
      <211> 353
      <212> PRT
      <213> Homo sapiens


      <400> 1338
 Met Ala Met Thr Leu Leu Glu Asp Trp Cys Arg Gly Met Asp Val Asn
   1               5                  10                  15    
 Ser Gln Arg Ala Leu Leu Val Trp Gly Ile Pro Val Asn Cys Asp Glu
              20                  25                  30        
 Ala Glu Ile Glu Glu Thr Leu Gln Ala Ala Met Pro Gln Val Ser Tyr
          35                  40                  45            
 Arg Met Leu Gly Arg Met Phe Trp Arg Glu Glu Asn Ala Lys Ala Ala
      50                  55                  60                
 Leu Leu Glu Leu Thr Gly Ala Val Asp Tyr Ala Ala Ile Pro Arg Glu
  65                  70                  75                  80
 Met Pro Gly Lys Gly Gly Val Trp Lys Val Leu Phe Lys Pro Pro Thr
                  85                  90                  95    
 Ser Asp Ala Glu Phe Leu Glu Arg Leu His Leu Phe Leu Ala Arg Glu
             100                 105                 110        
 Gly Trp Thr Val Gln Asp Val Ala Arg Val Leu Gly Phe Gln Asn Pro
         115                 120                 125            
 Thr Pro Thr Pro Gly Pro Glu Met Pro Ala Glu Met Leu Asn Tyr Ile
     130                 135                 140                
 Leu Asp Asn Val Ile Gln Pro Leu Val Glu Ser Ile Trp Tyr Lys Arg
 145                 150                 155                 160
 Leu Thr Leu Phe Ser Gly Arg Asp Ile Pro Gly Pro Gly Glu Glu Thr
                 165                 170                 175    
 Phe Asp Pro Trp Leu Glu His Thr Asn Glu Val Leu Glu Glu Trp Gln
             180                 185                 190        
 Val Ser Asp Val Glu Lys Arg Arg Arg Leu Met Glu Ser Leu Arg Gly
         195                 200                 205            
 Pro Ala Ala Asp Val Ile Arg Ile Leu Lys Ser Asn Asn Pro Ala Ile
     210                 215                 220                
 Thr Thr Ala Glu Cys Leu Lys Ala Leu Glu Gln Val Phe Gly Ser Val
 225                 230                 235                 240
 Glu Ser Ser Arg Asp Ala Gln Ile Lys Phe Leu Asn Thr Tyr Gln Asn
                 245                 250                 255    
 Pro Gly Glu Lys Leu Ser Ala Tyr Val Ile Arg Leu Glu Pro Leu Leu
             260                 265                 270        
 Gln Lys Val Val Glu Lys Gly Ala Ile Asp Lys Asp Asn Val Asn Gln
         275                 280                 285            
 Ala Arg Leu Glu Gln Val Ile Ala Gly Ala Asn His Ser Gly Ala Ile
     290                 295                 300                
 Arg Arg Gln Leu Trp Leu Thr Gly Ala Gly Glu Gly Pro Ala Pro Asn
 305                 310                 315                 320
 Leu Phe Gln Leu Leu Val Gln Ile Arg Glu Glu Glu Ala Lys Glu Glu
                 325                 330                 335    
 Glu Glu Glu Ala Glu Ala Thr Leu Leu Gln Leu Gly Leu Glu Gly His
             340                 345                 350        
 Phe
    



      <210> 1339
      <211> 326
      <212> PRT
      <213> Homo sapiens


      <400> 1339
 Met Thr Ile His Val Pro Leu Asp Ala Ser Arg Ser Lys Gln Leu Ile
   1               5                  10                  15    
 Ser Glu Trp Lys Gln Lys Ser Leu Glu Gly Arg Gly Leu Gly Leu Pro
              20                  25                  30        
 Asp Asp Ala Ser Pro Gly His Leu Arg Ala Pro Ala Glu Pro Met Ala
          35                  40                  45            
 Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu
      50                  55                  60                
 Glu Glu Glu Asp Glu Gly Pro Ala Pro Pro Ser Leu Tyr Pro Thr Val
  65                  70                  75                  80
 Gln Ala Arg Pro Gly Leu Gly Pro Arg Val Ile Leu Pro Pro Arg Ala
                  85                  90                  95    
 Gly Pro Pro Pro Leu Val His Ile Pro Glu Glu Gly Ala Gln Thr Gly
             100                 105                 110        
 Ala Gly Leu Ser Pro Lys Ser Gly Ala Gly Val Arg Ala Lys Trp Leu
         115                 120                 125            
 Met Met Ala Glu Lys Ser Gly Ala Ala Val Ala Asn Pro Pro Arg Leu
     130                 135                 140                
 Leu Gln Val Ile Ala Met Ser Lys Ala Pro Gly Ala Pro Gly Pro Lys
 145                 150                 155                 160
 Ala Ala Glu Thr Ala Ser Ser Ser Ser Ala Ser Ser Asp Ser Ser Gln
                 165                 170                 175    
 Tyr Arg Ser Pro Ser Asp Arg Asp Ser Ala Ser Ile Val Thr Ile Asp
             180                 185                 190        
 Ala His Ala Pro His His Pro Val Val His Leu Ser Ala Gly Gly Ala
         195                 200                 205            
 Pro Trp Glu Trp Lys Ala Ala Gly Gly Gly Ala Lys Ala Glu Ala Asp
     210                 215                 220                
 Gly Gly Tyr Glu Leu Gly Asp Leu Ala Arg Gly Phe Arg Gly Gly Ala
 225                 230                 235                 240
 Lys Pro Pro Gly Val Ser Pro Gly Ser Ser Val Ser Asp Val Asp Gln
                 245                 250                 255    
 Glu Glu Pro Arg Phe Gly Ala Val Ala Thr Val Asn Leu Ala Thr Gly
             260                 265                 270        
 Glu Gly Leu Pro Pro Leu Gly Ala Ala Asp Gly Ala Leu Gly Pro Gly
         275                 280                 285            
 Ser Arg Glu Ser Thr Leu Arg Arg His Ala Gly Gly Leu Gly Leu Ala
     290                 295                 300                
 Glu Arg Glu Ala Glu Ala Glu Ala Glu Gly Tyr Phe Arg Lys Met Gln
 305                 310                 315                 320
 Ala Arg Arg Phe Pro Asp
                 325    



      <210> 1340
      <211> 366
      <212> PRT
      <213> Homo sapiens


      <400> 1340
 Met Ala Ala Arg Thr Val Ile Ile Asp His Gly Ser Gly Phe Leu Lys
   1               5                  10                  15    
 Ala Gly Thr Ala Gly Trp Asn Glu Pro Gln Met Val Phe Pro Asn Ile
              20                  25                  30        
 Val Asn Tyr Leu Pro Cys Lys Glu Asn Pro Gly Pro Ser Tyr Ala Arg
          35                  40                  45            
 Arg Arg Val Ser Leu Gly Ile Asp Ile Cys His Pro Asp Thr Phe Ser
      50                  55                  60                
 Tyr Pro Ile Glu Arg Gly Arg Ile Leu Asn Trp Glu Gly Val Gln Tyr
  65                  70                  75                  80
 Leu Trp Ser Phe Val Leu Glu Asn His Arg Arg Glu Gln Glu Val Pro
                  85                  90                  95    
 Pro Val Ile Ile Thr Glu Thr Pro Leu Arg Glu Pro Ala Asp Arg Lys
             100                 105                 110        
 Lys Met Leu Glu Ile Leu Phe Glu Leu Leu His Val Pro Ser Val Leu
         115                 120                 125            
 Leu Ala Asp Gln Leu Gln Met Ser Leu Tyr Ala Ser Gly Leu Leu Thr
     130                 135                 140                
 Gly Val Val Val Asp Ser Gly Tyr Gly Leu Thr Arg Val Gln Pro Phe
 145                 150                 155                 160
 His Gln Gly Arg Pro Leu Pro Ala Ser Gly Lys Thr Leu Glu Phe Ala
                 165                 170                 175    
 Gly Gln Asp Leu Ser Ala Tyr Leu Leu Lys Ser Leu Phe Lys Glu Asp
             180                 185                 190        
 Cys Asp Arg Arg Cys Leu Phe Gln Leu Glu Thr Val Ala Val Thr Gln
         195                 200                 205            
 Met Asn Lys Cys Tyr Val Pro Gln Asn Leu Gly Glu Ala Leu Asp Phe
     210                 215                 220                
 Arg Glu Arg Gln Gln Ser Ala Leu Asp Glu Ser Asn Thr Tyr Gln Leu
 225                 230                 235                 240
 Pro Asp Gly Ser Arg Val Glu Leu Thr Pro Met Gln Arg Val Ala Pro
                 245                 250                 255    
 Glu Met Phe Phe Ser Pro Gln Val Phe Glu Gln Pro Gly Pro Ser Ile
             260                 265                 270        
 Pro Arg Ala Ile Val Glu Ser Val Glu Ser Cys Glu Ile Ser Leu Arg
         275                 280                 285            
 Pro Leu Leu Val Ser His Val Met Ala Cys Gly Gly Asn Thr Leu Tyr
     290                 295                 300                
 Pro Gly Phe Thr Lys Arg Leu Phe Arg Glu Leu Met Gly Asp His Val
 305                 310                 315                 320
 Ser Ser Thr Lys Ala Thr Val Trp Glu Gly Ser Asn Arg Asn Phe Ser
                 325                 330                 335    
 Val Trp Leu Gly Ala Ser Val Val Ala His Leu Ser Thr Tyr Gln Ser
             340                 345                 350        
 Glu Trp Met Ser Arg Glu Glu Tyr Gly Glu His Met Arg Met
         355                 360                 365    



      <210> 1341
      <211> 430
      <212> PRT
      <213> Homo sapiens


      <400> 1341
 Met Ser Ser Arg Ser Pro Arg Pro Pro Pro Arg Arg Ser Arg Arg Arg
   1               5                  10                  15    
 Leu Pro Arg Pro Ser Cys Cys Cys Cys Cys Cys Arg Arg Ser His Leu
              20                  25                  30        
 Asn Glu Asp Thr Gly Arg Phe Val Leu Leu Ala Ala Leu Ile Gly Leu
          35                  40                  45            
 Tyr Leu Val Ala Gly Ala Thr Val Phe Ser Ala Leu Glu Ser Pro Gly
      50                  55                  60                
 Glu Ala Glu Ala Arg Ala Arg Trp Gly Ala Thr Leu Arg Asn Phe Ser
  65                  70                  75                  80
 Ala Ala His Gly Val Ala Glu Pro Glu Leu Arg Ala Phe Leu Arg His
                  85                  90                  95    
 Tyr Glu Ala Ala Leu Ala Ala Gly Val Arg Ala Asp Ala Leu Arg Pro
             100                 105                 110        
 Arg Trp Asp Phe Pro Gly Ala Phe Tyr Phe Val Gly Thr Val Val Ser
         115                 120                 125            
 Thr Ile Gly Phe Gly Met Thr Thr Pro Ala Thr Val Gly Gly Lys Ala
     130                 135                 140                
 Phe Leu Ile Ala Tyr Gly Leu Phe Gly Cys Ala Gly Thr Ile Leu Phe
 145                 150                 155                 160
 Phe Asn Leu Phe Leu Glu Arg Ile Ile Ser Leu Leu Ala Phe Ile Met
                 165                 170                 175    
 Arg Ala Cys Arg Glu Arg Gln Leu Arg Arg Ser Gly Leu Leu Pro Ala
             180                 185                 190        
 Thr Phe Arg Arg Gly Ser Ala Leu Ser Glu Ala Asp Ser Leu Ala Gly
         195                 200                 205            
 Trp Lys Pro Ser Val Tyr His Val Leu Leu Ile Leu Gly Leu Phe Ala
     210                 215                 220                
 Val Leu Leu Ser Cys Cys Ala Ser Ala Met Tyr Thr Ser Val Glu Gly
 225                 230                 235                 240
 Trp Asp Tyr Val Asp Ser Leu Tyr Phe Cys Phe Val Thr Phe Ser Thr
                 245                 250                 255    
 Ile Gly Phe Gly Asp Leu Val Ser Ser Gln His Ala Ala Tyr Arg Asn
             260                 265                 270        
 Gln Gly Leu Tyr Arg Leu Gly Asn Phe Leu Phe Ile Leu Leu Gly Val
         275                 280                 285            
 Cys Cys Ile Tyr Ser Leu Phe Asn Val Ile Ser Ile Leu Ile Lys Gln
     290                 295                 300                
 Val Leu Asn Trp Met Leu Arg Lys Leu Ser Cys Arg Cys Cys Ala Arg
 305                 310                 315                 320
 Cys Cys Pro Ala Pro Gly Ala Pro Leu Ala Arg Arg Asn Ala Ile Thr
                 325                 330                 335    
 Pro Gly Ser Arg Leu Arg Arg Arg Leu Ala Ala Leu Gly Ala Asp Pro
             340                 345                 350        
 Ala Ala Arg Asp Ser Asp Ala Glu Gly Arg Arg Leu Ser Gly Glu Leu
         355                 360                 365            
 Ile Ser Met Arg Asp Leu Thr Ala Ser Asn Lys Val Ser Leu Ala Leu
     370                 375                 380                
 Leu Gln Lys Gln Leu Ser Glu Thr Ala Asn Gly Tyr Pro Arg Ser Val
 385                 390                 395                 400
 Cys Val Asn Thr Arg Gln Asn Gly Phe Ser Gly Gly Val Gly Ala Leu
                 405                 410                 415    
 Gly Ile Met Asn Asn Arg Leu Ala Glu Thr Ser Ala Ser Arg
             420                 425                 430



      <210> 1342
      <211> 235
      <212> PRT
      <213> Homo sapiens


      <400> 1342
 Met Glu Gln Asp Asp Pro Val Glu Ala Leu Thr Glu Leu Arg Glu Arg
   1               5                  10                  15    
 Arg Leu Gly Ala Leu Glu Leu Leu Gln Ala Ala Ala Gly Ser Gly Leu
              20                  25                  30        
 Ala Ala Tyr Ala Val Trp Ala Leu Leu Leu Gln Pro Gly Phe Arg Arg
          35                  40                  45            
 Val Pro Leu Arg Leu Gln Val Pro Tyr Val Gly Ala Ser Ala Arg Gln
      50                  55                  60                
 Val Glu His Val Leu Ser Leu Leu Arg Gly Arg Pro Gly Lys Thr Val
  65                  70                  75                  80
 Asp Leu Gly Ser Gly Asp Gly Arg Ile Val Leu Ala Ala His Arg Cys
                  85                  90                  95    
 Gly Leu Arg Pro Ala Val Gly Tyr Glu Leu Asn Pro Trp Leu Val Ala
             100                 105                 110        
 Leu Ala Arg Leu His Ala Trp Arg Ala Gly Cys Ala Gly Ser Val Cys
         115                 120                 125            
 Tyr Arg Arg Lys Asp Leu Trp Lys Val Ser Leu Arg Asp Cys Arg Asn
     130                 135                 140                
 Val Ser Val Phe Leu Ala Pro Ser Val Leu Pro Leu Leu Glu Asp Lys
 145                 150                 155                 160
 Leu Arg Thr Glu Leu Pro Ala Gly Ala Arg Val Val Ser Gly Arg Phe
                 165                 170                 175    
 Pro Leu Pro Thr Trp Gln Pro Val Thr Ala Val Gly Glu Gly Leu Asp
             180                 185                 190        
 Arg Val Trp Ala Tyr Asp Val Pro Glu Gly Gly Gln Ala Gly Glu Ala
         195                 200                 205            
 Ala Ser Ser Arg Ile Pro Ile Gln Ala Ala Pro Gly Pro Ser Ser Ala
     210                 215                 220                
 Pro Ile Pro Gly Gly Leu Ile Ser Gln Ala Ser
 225                 230                 235



      <210> 1343
      <211> 673
      <212> PRT
      <213> Homo sapiens


      <400> 1343
 Met Trp Phe Val Glu Phe Ile Gln Val Asn Leu Tyr Arg Val Pro Val
   1               5                  10                  15    
 Val Cys Arg Ala Leu Phe Trp Leu Leu Ala Thr Gln Thr Ser Lys Thr
              20                  25                  30        
 Cys Ser Leu Asn Ser Arg Asn Leu Gln Ser Leu Val Lys Val Ile Gly
          35                  40                  45            
 Asp Leu Asn Asn Cys Arg Glu Trp Leu Lys Pro Val Thr Asn Glu Ile
      50                  55                  60                
 Asn Lys Arg Val Pro Glu Lys Gln Phe Arg Ala Leu Val Ser Lys Lys
  65                  70                  75                  80
 Ile Lys His Pro Leu Ile Ile Ser Asp Val Tyr Pro Lys Ser Glu Lys
                  85                  90                  95    
 Leu Lys Glu Leu Lys Arg Gln Ile Lys Ile Lys Thr Ile Ser Ala Phe
             100                 105                 110        
 Glu Val Gln Pro Ile Ser Thr Glu Val His Glu Gly Gly Val Ala Arg
         115                 120                 125            
 Phe Ala Cys Lys Ile Ser Ser His Pro Pro Ala Val Ile Thr Trp Glu
     130                 135                 140                
 Phe Asn Arg Thr Thr Leu Pro Met Thr Met Asp Arg Ile Thr Ala Leu
 145                 150                 155                 160
 Pro Thr Gly Val Leu Gln Ile Tyr Asp Val Ser Gln Arg Asp Ser Gly
                 165                 170                 175    
 Asn Tyr Arg Cys Ile Ala Ala Thr Val Ala His Arg Arg Lys Ser Met
             180                 185                 190        
 Glu Ala Ser Leu Thr Val Ile Pro Ala Lys Glu Ser Lys Ser Phe His
         195                 200                 205            
 Thr Pro Thr Ile Ile Ala Gly Pro Gln Asn Ile Thr Thr Ser Leu His
     210                 215                 220                
 Gln Thr Val Val Leu Glu Cys Met Ala Thr Gly Asn Pro Lys Pro Ile
 225                 230                 235                 240
 Ile Ser Trp Ser Arg Leu Asp His Lys Ser Ile Asp Val Phe Asn Thr
                 245                 250                 255    
 Arg Val Leu Gly Asn Gly Asn Leu Met Ile Ser Asp Val Arg Leu Gln
             260                 265                 270        
 His Ala Gly Val Tyr Val Cys Arg Ala Thr Thr Pro Gly Thr Arg Asn
         275                 280                 285            
 Phe Thr Val Ala Met Ala Thr Leu Thr Val Leu Ala Pro Pro Ser Phe
     290                 295                 300                
 Val Glu Trp Pro Glu Ser Leu Thr Arg Pro Arg Ala Gly Thr Ala Arg
 305                 310                 315                 320
 Phe Val Cys Gln Ala Glu Gly Ile Pro Ser Pro Lys Met Ser Trp Leu
                 325                 330                 335    
 Lys Asn Gly Arg Lys Ile His Ser Asn Gly Arg Ile Lys Met Tyr Asn
             340                 345                 350        
 Ser Lys Leu Val Ile Asn Gln Ile Ile Pro Glu Asp Asp Ala Ile Tyr
         355                 360                 365            
 Gln Cys Met Ala Glu Asn Ser Gln Gly Ser Ile Leu Ser Arg Ala Arg
     370                 375                 380                
 Leu Thr Val Val Met Ser Glu Asp Arg Pro Ser Ala Pro Tyr Asn Val
 385                 390                 395                 400
 His Ala Glu Thr Met Ser Ser Ser Ala Ile Leu Leu Ala Trp Glu Arg
                 405                 410                 415    
 Pro Leu Tyr Asn Ser Asp Lys Val Ile Ala Tyr Ser Val His Tyr Met
             420                 425                 430        
 Lys Ala Glu Gly Leu Asn Asn Glu Glu Tyr Gln Val Val Ile Gly Asn
         435                 440                 445            
 Asp Thr Thr His Tyr Ile Ile Asp Asp Leu Glu Pro Ala Ser Asn Tyr
     450                 455                 460                
 Thr Phe Tyr Ile Val Ala Tyr Met Pro Met Gly Ala Ser Gln Met Ser
 465                 470                 475                 480
 Asp His Val Thr Gln Asn Thr Leu Glu Asp Val Pro Leu Arg Pro Pro
                 485                 490                 495    
 Glu Ile Ser Leu Thr Ser Arg Ser Pro Thr Asp Ile Leu Ile Ser Trp
             500                 505                 510        
 Leu Pro Ile Pro Ala Lys Tyr Arg Arg Gly Gln Val Val Leu Tyr Arg
         515                 520                 525            
 Leu Ser Phe Arg Leu Ser Thr Glu Asn Ser Ile Gln Val Leu Glu Leu
     530                 535                 540                
 Pro Gly Thr Thr His Glu Tyr Leu Leu Glu Gly Leu Lys Pro Asp Ser
 545                 550                 555                 560
 Val Tyr Leu Val Arg Ile Thr Ala Ala Thr Arg Val Gly Leu Gly Glu
                 565                 570                 575    
 Ser Ser Val Trp Thr Ser His Arg Thr Pro Lys Ala Thr Ser Val Lys
             580                 585                 590        
 Ala Lys Ser Pro Glu Leu His Leu Glu Pro Leu Asn Cys Thr Thr Ile
         595                 600                 605            
 Ser Val Arg Trp Gln Gln Asp Val Glu Asp Thr Ala Ala Ile Gln Gly
     610                 615                 620                
 Tyr Lys Leu Tyr Tyr Lys Glu Glu Gly Gln Gln Glu Asn Gly Pro Ile
 625                 630                 635                 640
 Phe Leu Asp Thr Lys Asp Leu Leu Tyr Thr Leu Ser Gly Leu Asp Cys
                 645                 650                 655    
 Pro Val Lys Glu Leu Glu Gln Leu Pro Gln Leu Ser Val Thr Val Thr
             660                 665                 670        
 Ser
    



      <210> 1344
      <211> 970
      <212> PRT
      <213> Homo sapiens


      <400> 1344
 Met Glu Val Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys
   1               5                  10                  15    
 Arg Gly Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala
              20                  25                  30        
 Gly Gln Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr
          35                  40                  45            
 Thr Ile Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly
      50                  55                  60                
 His Pro Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser
  65                  70                  75                  80
 Asp Lys Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu
                  85                  90                  95    
 Arg Ile Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn
             100                 105                 110        
 Gly Val Gly Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr
         115                 120                 125            
 Leu Asp Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg
     130                 135                 140                
 Gly Asn Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn
 145                 150                 155                 160
 Ser Asn Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu
                 165                 170                 175    
 Ser His Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr
             180                 185                 190        
 Gln Gly Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp
         195                 200                 205            
 Tyr Ala Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile
     210                 215                 220                
 Pro Asp Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro
 225                 230                 235                 240
 Ala Leu Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu
                 245                 250                 255    
 Asn Val Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln
             260                 265                 270        
 Leu Gln Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala
         275                 280                 285            
 Gln Gly Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly
     290                 295                 300                
 Tyr Tyr Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys
 305                 310                 315                 320
 Thr Val Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile
                 325                 330                 335    
 Thr Pro Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp
             340                 345                 350        
 Leu Lys Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr
         355                 360                 365            
 Tyr Gln Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu
     370                 375                 380                
 Leu Val Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu
 385                 390                 395                 400
 Glu Leu Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met
                 405                 410                 415    
 Ala Ser Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn
             420                 425                 430        
 Ile Ser Ser Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg
         435                 440                 445            
 Ala Val Val Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu
     450                 455                 460                
 Val Arg Gly Lys Pro Arg Pro Pro Val Leu Trp Ser Arg Val Asp Lys
 465                 470                 475                 480
 Glu Ala Ala Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu Thr Pro Asp
                 485                 490                 495    
 Gly Lys Leu Arg Leu Glu Arg Val Ser Arg Asp Met Ser Gly Thr Tyr
             500                 505                 510        
 Arg Cys Gln Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg Pro Arg Glu
         515                 520                 525            
 Ala Gln Val Gln Leu Asn Val Gln Phe Pro Pro Glu Val Glu Pro Ser
     530                 535                 540                
 Ser Gln Asp Val Arg Gln Ala Leu Gly Arg Pro Val Leu Leu Arg Cys
 545                 550                 555                 560
 Ser Leu Leu Arg Gly Ser Pro Gln Arg Ile Ala Ser Ala Val Trp Arg
                 565                 570                 575    
 Phe Lys Gly Gln Leu Leu Pro Pro Pro Pro Val Val Pro Ala Ala Ala
             580                 585                 590        
 Glu Ala Pro Asp His Ala Glu Leu Arg Leu Asp Ala Val Thr Arg Asp
         595                 600                 605            
 Ser Ser Gly Ser Tyr Glu Cys Ser Val Ser Asn Asp Val Gly Ser Ala
     610                 615                 620                
 Ala Cys Leu Phe Gln Val Ser Ala Lys Ala Tyr Ser Pro Glu Phe Tyr
 625                 630                 635                 640
 Phe Asp Thr Pro Asn Pro Thr Arg Ser His Lys Leu Ser Lys Asn Tyr
                 645                 650                 655    
 Ser Tyr Val Leu Gln Trp Thr Gln Arg Glu Pro Asp Ala Val Asp Pro
             660                 665                 670        
 Val Leu Asn Tyr Arg Leu Ser Ile Arg Gln Leu Asn Gln His Asn Ala
         675                 680                 685            
 Val Val Lys Ala Ile Pro Val Arg Arg Val Glu Lys Gly Gln Leu Leu
     690                 695                 700                
 Glu Tyr Ile Leu Thr Asp Leu Arg Val Pro His Ser Tyr Glu Val Arg
 705                 710                 715                 720
 Leu Thr Pro Tyr Thr Thr Phe Gly Ala Gly Asp Met Ala Ser Arg Ile
                 725                 730                 735    
 Ile His Tyr Thr Glu Pro Ile Asn Ser Pro Asn Leu Ser Asp Asn Thr
             740                 745                 750        
 Cys His Phe Glu Asp Glu Lys Ile Cys Gly Tyr Thr Gln Asp Leu Thr
         755                 760                 765            
 Asp Asn Phe Asp Trp Thr Arg Gln Asn Ala Leu Thr Gln Asn Pro Lys
     770                 775                 780                
 Arg Ser Pro Asn Thr Gly Pro Pro Thr Asp Ile Ser Gly Thr Pro Glu
 785                 790                 795                 800
 Gly Tyr Tyr Met Phe Ile Glu Thr Ser Arg Pro Arg Glu Leu Gly Asp
                 805                 810                 815    
 Arg Ala Arg Leu Val Ser Pro Leu Tyr Asn Ala Ser Ala Lys Phe Tyr
             820                 825                 830        
 Cys Val Ser Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu
         835                 840                 845            
 Asn Leu Leu Val Arg Ser Arg Asn Lys Gly Ala Leu Asp Thr His Ala
     850                 855                 860                
 Trp Ser Leu Ser Gly Asn Lys Gly Asn Val Trp Gln Gln Ala His Val
 865                 870                 875                 880
 Pro Ile Ser Pro Ser Gly Pro Phe Gln Ile Ile Phe Glu Gly Val Arg
                 885                 890                 895    
 Gly Pro Gly Tyr Leu Gly Asp Ile Ala Ile Asp Asp Val Thr Leu Lys
             900                 905                 910        
 Lys Gly Glu Cys Pro Arg Lys Gln Thr Asp Pro Asn Lys Gly Ala Arg
         915                 920                 925            
 Arg Glu Gly Gly Gly Gly Ala Glu Ser Gly Gly Ser Cys Ala Trp Arg
     930                 935                 940                
 Gly Phe Leu Ser Val Glu Gly Gly Cys Ser Gly Leu Asn Arg Gly Ser
 945                 950                 955                 960
 Asp Cys Leu Met Met Gly Ile Arg Trp Leu
                 965                 970



      <210> 1345
      <211> 304
      <212> PRT
      <213> Homo sapiens


      <400> 1345
 Met Leu Pro Pro Pro Arg Pro Ala Ala Ala Leu Ala Leu Pro Val Leu
   1               5                  10                  15    
 Leu Leu Leu Leu Val Val Leu Thr Pro Pro Pro Thr Gly Ala Arg Pro
              20                  25                  30        
 Ser Pro Gly Pro Asp Tyr Leu Arg Arg Gly Trp Met Arg Leu Leu Ala
          35                  40                  45            
 Glu Gly Glu Gly Cys Ala Pro Cys Arg Pro Glu Glu Cys Ala Ala Pro
      50                  55                  60                
 Arg Gly Cys Leu Ala Gly Arg Val Arg Asp Ala Cys Gly Cys Cys Trp
  65                  70                  75                  80
 Glu Cys Ala Asn Leu Glu Gly Gln Leu Cys Asp Leu Asp Pro Ser Ala
                  85                  90                  95    
 His Phe Tyr Gly His Cys Gly Glu Gln Leu Glu Cys Arg Leu Asp Thr
             100                 105                 110        
 Gly Gly Asp Leu Ser Arg Gly Glu Val Pro Glu Pro Leu Cys Ala Cys
         115                 120                 125            
 Arg Ser Gln Ser Pro Leu Cys Gly Ser Asp Gly His Thr Tyr Ser Gln
     130                 135                 140                
 Ile Cys Arg Leu Gln Glu Ala Ala Arg Ala Arg Pro Asp Ala Asn Leu
 145                 150                 155                 160
 Thr Val Ala His Pro Gly Pro Cys Glu Ser Gly Pro Gln Ile Val Ser
                 165                 170                 175    
 His Pro Tyr Asp Thr Trp Asn Val Thr Gly Gln Asp Val Ile Phe Gly
             180                 185                 190        
 Cys Glu Val Phe Ala Tyr Pro Met Ala Ser Ile Glu Trp Arg Lys Asp
         195                 200                 205            
 Gly Leu Asp Ile Gln Leu Pro Gly Asp Asp Pro His Ile Ser Val Gln
     210                 215                 220                
 Phe Arg Gly Gly Pro Gln Arg Phe Glu Val Thr Gly Trp Leu Gln Ile
 225                 230                 235                 240
 Gln Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr Arg Cys Leu Gly Arg
                 245                 250                 255    
 Asn Ala Leu Gly Gln Val Glu Ala Pro Ala Ser Leu Thr Val Leu Thr
             260                 265                 270        
 Pro Asp Gln Leu Asn Ser Thr Gly Ile Pro Gln Leu Arg Ser Leu Asn
         275                 280                 285            
 Leu Val Pro Glu Glu Glu Ala Glu Ser Glu Glu Asn Asp Asp Tyr Tyr
     290                 295                 300                





      <210> 1346
      <211> 811
      <212> PRT
      <213> Homo sapiens


      <400> 1346
 Met Glu Ala Lys Asp Gln Lys Lys His Arg Lys Lys Asn Ser Gly Pro
   1               5                  10                  15    
 Lys Ala Ala Lys Lys Lys Lys Arg Leu Leu Gln Asp Leu Gln Leu Gly
              20                  25                  30        
 Asp Glu Glu Asp Ala Arg Lys Arg Asn Pro Lys Ala Phe Ala Val Gln
          35                  40                  45            
 Ser Ala Val Arg Met Ala Arg Ser Phe His Arg Thr Gln Asp Leu Lys
      50                  55                  60                
 Thr Lys Lys His His Ile Pro Val Val Asp Arg Thr Pro Leu Glu Pro
  65                  70                  75                  80
 Pro Pro Ile Val Val Val Val Met Gly Pro Pro Lys Val Gly Lys Ser
                  85                  90                  95    
 Thr Leu Ile Gln Cys Leu Ile Arg Asn Phe Thr Arg Gln Lys Leu Thr
             100                 105                 110        
 Glu Ile Arg Gly Pro Val Thr Ile Val Ser Gly Lys Lys Arg Arg Leu
         115                 120                 125            
 Thr Ile Ile Glu Cys Gly Cys Asp Ile Asn Met Met Ile Asp Leu Ala
     130                 135                 140                
 Lys Val Ala Asp Leu Val Leu Met Leu Ile Asp Ala Ser Phe Gly Phe
 145                 150                 155                 160
 Glu Met Glu Thr Phe Glu Phe Leu Asn Ile Cys Gln Val His Gly Phe
                 165                 170                 175    
 Pro Lys Ile Met Gly Val Leu Thr His Leu Asp Ser Phe Lys His Asn
             180                 185                 190        
 Lys Gln Leu Lys Lys Thr Lys Lys Arg Leu Lys His Arg Phe Trp Thr
         195                 200                 205            
 Glu Val Tyr Pro Gly Ala Lys Leu Phe Tyr Leu Ser Gly Met Val His
     210                 215                 220                
 Gly Glu Tyr Gln Asn Gln Glu Ile His Asn Leu Gly Arg Phe Ile Thr
 225                 230                 235                 240
 Val Met Lys Phe Arg Pro Leu Thr Trp Gln Thr Ser His Pro Tyr Ile
                 245                 250                 255    
 Leu Ala Asp Arg Met Glu Asp Leu Thr Asn Pro Glu Asp Ile Arg Thr
             260                 265                 270        
 Asn Ile Lys Cys Asp Arg Lys Val Ser Leu Tyr Gly Tyr Leu Arg Gly
         275                 280                 285            
 Ala His Leu Lys Asn Lys Ser Gln Ile His Met Pro Gly Val Gly Asp
     290                 295                 300                
 Phe Ala Val Ser Asp Ile Ser Phe Leu Pro Asp Pro Cys Ala Leu Pro
 305                 310                 315                 320
 Glu Gln Gln Lys Lys Arg Cys Leu Asn Glu Lys Glu Lys Leu Val Tyr
                 325                 330                 335    
 Ala Pro Leu Ser Gly Val Gly Gly Val Leu Tyr Asp Lys Asp Ala Val
             340                 345                 350        
 Tyr Val Asp Leu Gly Gly Ser His Val Phe Gln Asp Glu Val Gly Pro
         355                 360                 365            
 Thr His Glu Leu Val Gln Ser Leu Ile Ser Thr His Ser Thr Ile Asp
     370                 375                 380                
 Ala Lys Met Ala Ser Ser Arg Val Thr Leu Phe Ser Asp Ser Lys Pro
 385                 390                 395                 400
 Leu Gly Ser Glu Asp Ile Asp Asn Gln Gly Leu Met Met Pro Lys Glu
                 405                 410                 415    
 Glu Lys Gln Met Asp Leu Asn Thr Gly Arg Met Arg Arg Lys Ala Ile
             420                 425                 430        
 Phe Gly Asp Glu Asp Glu Ser Gly Asp Ser Asp Asp Glu Glu Asp Asp
         435                 440                 445            
 Glu Met Ser Glu Asp Asp Gly Leu Glu Asn Gly Ser Ser Asp Glu Glu
     450                 455                 460                
 Ala Glu Glu Glu Glu Asn Ala Glu Met Thr Asp Gln Tyr Met Ala Val
 465                 470                 475                 480
 Lys Gly Ile Lys Arg Arg Lys Leu Glu Leu Glu Glu Asp Ser Glu Met
                 485                 490                 495    
 Asp Leu Pro Ala Phe Ala Asp Ser Asp Asp Asp Leu Glu Arg Ser Ser
             500                 505                 510        
 Ala Glu Glu Gly Glu Ala Glu Glu Ala Asp Glu Ser Ser Glu Glu Glu
         515                 520                 525            
 Asp Cys Thr Ala Gly Glu Lys Gly Ile Ser Gly Ser Lys Ala Ala Gly
     530                 535                 540                
 Glu Gly Ser Lys Ala Gly Leu Ser Pro Ala Asn Cys Gln Ser Asp Arg
 545                 550                 555                 560
 Val Asn Leu Glu Lys Ser Leu Leu Met Lys Lys Ala Ala Leu Pro Thr
                 565                 570                 575    
 Phe Asp Ser Gly His Cys Thr Ala Glu Glu Val Phe Ala Ser Glu Asp
             580                 585                 590        
 Glu Ser Glu Glu Ser Ser Ser Leu Ser Ala Glu Glu Glu Asp Ser Glu
         595                 600                 605            
 Asn Glu Glu Ala Ile Arg Lys Lys Leu Ser Lys Pro Ser Gln Val Ser
     610                 615                 620                
 Ser Gly Gln Lys Leu Gly Pro Gln Asn Phe Ile Asp Glu Thr Ser Asp
 625                 630                 635                 640
 Ile Glu Asn Leu Leu Lys Glu Glu Glu Asp Tyr Lys Glu Glu Asn Asn
                 645                 650                 655    
 Asp Ser Lys Glu Thr Ser Gly Ala Leu Lys Trp Lys Glu Asp Leu Ser
             660                 665                 670        
 Arg Lys Ala Ala Glu Ala Phe Leu Arg Gln Gln Gln Ala Ala Pro Asn
         675                 680                 685            
 Leu Arg Lys Leu Ile Tyr Gly Thr Val Thr Glu Asp Asn Glu Glu Glu
     690                 695                 700                
 Asp Asp Asp Thr Leu Glu Glu Leu Gly Gly Leu Phe Arg Val Asn Gln
 705                 710                 715                 720
 Pro Asp Arg Glu Cys Lys His Lys Ala Asp Ser Leu Asp Cys Ser Arg
                 725                 730                 735    
 Phe Leu Val Glu Ala Pro His Asp Trp Asp Leu Glu Glu Val Met Asn
             740                 745                 750        
 Ser Ile Arg Asp Cys Phe Val Thr Gly Lys Trp Glu Asp Asp Lys Asp
         755                 760                 765            
 Ala Ala Lys Val Leu Ala Glu Asp Glu Glu Leu Tyr Gly Asp Phe Glu
     770                 775                 780                
 Asp Leu Glu Thr Gly Asp Val His Lys Gly Lys Ser Gly Pro Asp Thr
 785                 790                 795                 800
 Gln Asn Glu Asp Ile Glu Lys Gln Gly Arg Asn
                 805                 810    



      <210> 1347
      <211> 248
      <212> PRT
      <213> Homo sapiens


      <400> 1347
 Met Pro Arg Gly Phe Thr Trp Leu Arg Tyr Leu Gly Ile Phe Leu Gly
   1               5                  10                  15    
 Val Ala Leu Gly Asn Glu Pro Leu Glu Met Trp Pro Leu Thr Gln Asn
              20                  25                  30        
 Glu Glu Cys Thr Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg
          35                  40                  45            
 Ser Arg Leu Gln Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Lys Ile
      50                  55                  60                
 Ser Val Pro Tyr Glu Gly Val Phe Arg Ile Ala Asn Val Thr Arg Leu
  65                  70                  75                  80
 Gln Arg Ala Gln Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu
                  85                  90                  95    
 Val Ser Leu Ser Ala Thr Glu Ser Val Gln Asp Val Leu Leu Glu Gly
             100                 105                 110        
 His Pro Ser Trp Lys Tyr Leu Gln Glu Val Gln Thr Leu Leu Leu Asn
         115                 120                 125            
 Val Gln Gln Gly Leu Thr Asp Val Glu Val Ser Pro Lys Val Glu Ser
     130                 135                 140                
 Val Leu Ser Leu Leu Asn Ala Pro Gly Pro Asn Leu Lys Leu Val Arg
 145                 150                 155                 160
 Pro Lys Ala Leu Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr
                 165                 170                 175    
 Cys Ser Cys Cys Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu
             180                 185                 190        
 Val Pro Ser Pro Gln Ser Cys Ser Pro Glu Pro Ser Leu Gln Tyr Ala
         195                 200                 205            
 Ala Thr Gln Leu Tyr Pro Pro Gly Pro Val Val Pro Gln Leu Pro Ala
     210                 215                 220                
 Ser Leu His Gly Leu Gly Glu Val Arg Ser Gly His Arg Ala Arg Ala
 225                 230                 235                 240
 Ser Cys Pro Glu His Pro Gly Trp
                 245            



      <210> 1348
      <211> 1044
      <212> PRT
      <213> Homo sapiens


      <400> 1348
 Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys
   1               5                  10                  15    
 Leu Ala Gly Ser Gln Thr Asp Phe Trp Ser Leu Leu Gly Val Leu Pro
              20                  25                  30        
 Ala Leu Glu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln
          35                  40                  45            
 Glu Pro Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val
      50                  55                  60                
 Lys Leu Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp
  65                  70                  75                  80
 Lys Leu Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser
                  85                  90                  95    
 Val Val Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp
             100                 105                 110        
 Ala Gly Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val
         115                 120                 125            
 Ser Arg Glu Ala Lys Leu Gln Phe Ala Tyr Leu Asp Asn Phe Lys Thr
     130                 135                 140                
 Arg Thr Arg Ser Thr Val Ser Val Arg Arg Gly Gln Gly Met Val Leu
 145                 150                 155                 160
 Leu Cys Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile
                 165                 170                 175    
 Phe Asn Glu Tyr Pro Ser Tyr Gln Asp Asn Arg Arg Phe Val Ser Gln
             180                 185                 190        
 Glu Thr Gly Asn Leu Tyr Ile Ala Lys Val Glu Lys Ser Asp Val Gly
         195                 200                 205            
 Asn Tyr Thr Cys Val Val Thr Asn Thr Val Thr Asn His Lys Val Leu
     210                 215                 220                
 Gly Pro Pro Thr Pro Leu Ile Leu Arg Asn Asp Gly Val Met Gly Glu
 225                 230                 235                 240
 Tyr Glu Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Val Pro Thr Ala
                 245                 250                 255    
 Lys Gly Ala Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val
             260                 265                 270        
 Pro Thr Ile Ile Trp Arg Arg Ala Asp Gly Lys Pro Ile Ala Arg Lys
         275                 280                 285            
 Ala Arg Arg His Lys Ser Asn Gly Ile Leu Glu Ile Pro Asn Phe Gln
     290                 295                 300                
 Gln Glu Asp Ala Gly Leu Tyr Glu Cys Val Ala Glu Asn Ser Arg Gly
 305                 310                 315                 320
 Lys Asn Val Ala Arg Gly Gln Leu Thr Phe Tyr Ala Gln Pro Asn Trp
                 325                 330                 335    
 Ile Gln Lys Ile Asn Asp Ile His Val Ala Met Glu Glu Asn Val Phe
             340                 345                 350        
 Trp Glu Cys Lys Ala Asn Gly Arg Pro Lys Pro Thr Tyr Lys Trp Leu
         355                 360                 365            
 Lys Asn Gly Glu Pro Leu Leu Thr Arg Asp Arg Ile Gln Ile Glu Gln
     370                 375                 380                
 Gly Thr Leu Asn Ile Thr Ile Val Asn Leu Ser Asp Ala Gly Met Tyr
 385                 390                 395                 400
 Gln Cys Leu Ala Glu Asn Lys His Gly Val Ile Phe Ser Asn Ala Glu
                 405                 410                 415    
 Leu Ser Val Ile Ala Val Gly Pro Asp Phe Ser Arg Thr Leu Leu Lys
             420                 425                 430        
 Arg Val Thr Leu Val Lys Val Gly Gly Glu Val Val Ile Glu Cys Lys
         435                 440                 445            
 Pro Lys Ala Ser Pro Lys Pro Val Tyr Thr Trp Lys Lys Gly Arg Asp
     450                 455                 460                
 Ile Leu Lys Glu Asn Glu Arg Ile Thr Ile Ser Glu Asp Gly Asn Leu
 465                 470                 475                 480
 Arg Ile Ile Asn Val Thr Lys Ser Asp Ala Gly Ser Tyr Thr Cys Ile
                 485                 490                 495    
 Ala Thr Asn His Phe Gly Thr Ala Ser Ser Thr Gly Asn Leu Val Val
             500                 505                 510        
 Lys Asp Pro Thr Arg Val Met Val Pro Pro Ser Ser Met Asp Val Thr
         515                 520                 525            
 Val Gly Glu Ser Ile Val Leu Pro Cys Gln Val Thr His Asp His Ser
     530                 535                 540                
 Leu Asp Ile Val Phe Thr Trp Ser Phe Asn Gly His Leu Ile Asp Phe
 545                 550                 555                 560
 Asp Arg Asp Gly Asp His Phe Glu Arg Val Gly Gly Gln Asp Ser Ala
                 565                 570                 575    
 Gly Asp Leu Met Ile Arg Asn Ile Gln Leu Lys His Ala Gly Lys Tyr
             580                 585                 590        
 Val Cys Met Val Gln Thr Ser Val Asp Arg Leu Ser Ala Ala Ala Asp
         595                 600                 605            
 Leu Ile Val Arg Gly Pro Pro Gly Pro Pro Glu Ala Val Thr Ile Asp
     610                 615                 620                
 Glu Ile Thr Asp Thr Thr Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp
 625                 630                 635                 640
 Asn His Ser Pro Ile Thr Met Tyr Val Ile Gln Ala Arg Thr Pro Phe
                 645                 650                 655    
 Ser Val Gly Trp Gln Ala Val Ser Thr Val Pro Glu Leu Ile Asp Gly
             660                 665                 670        
 Lys Thr Phe Thr Ala Thr Val Val Gly Leu Asn Pro Trp Val Glu Tyr
         675                 680                 685            
 Glu Phe Arg Thr Val Ala Ala Asn Val Ile Gly Ile Gly Glu Pro Ser
     690                 695                 700                
 Arg Pro Ser Glu Lys Arg Arg Thr Glu Glu Ala Leu Pro Glu Val Thr
 705                 710                 715                 720
 Pro Ala Asn Val Ser Gly Gly Gly Gly Ser Lys Ser Glu Leu Val Ile
                 725                 730                 735    
 Thr Trp Glu Thr Val Pro Glu Glu Leu Gln Asn Gly Arg Gly Phe Gly
             740                 745                 750        
 Tyr Val Val Ala Phe Arg Pro Tyr Gly Lys Met Ile Trp Met Leu Thr
         755                 760                 765            
 Val Leu Ala Ser Ala Asp Ala Ser Arg Tyr Val Phe Arg Asn Glu Ser
     770                 775                 780                
 Val His Pro Phe Ser Pro Phe Glu Val Lys Val Gly Val Phe Asn Asn
 785                 790                 795                 800
 Lys Gly Glu Gly Pro Phe Ser Pro Thr Thr Val Val Tyr Ser Ala Glu
                 805                 810                 815    
 Glu Glu Pro Thr Lys Pro Pro Ala Ser Ile Phe Ala Arg Ser Leu Ser
             820                 825                 830        
 Ala Thr Asp Ile Glu Val Phe Trp Ala Ser Pro Leu Glu Lys Asn Arg
         835                 840                 845            
 Gly Arg Ile Gln Gly Tyr Glu Val Lys Tyr Trp Arg His Glu Asp Lys
     850                 855                 860                
 Glu Glu Asn Ala Arg Lys Ile Arg Thr Val Gly Asn Gln Thr Ser Thr
 865                 870                 875                 880
 Lys Ile Thr Asn Leu Lys Gly Ser Val Leu Tyr His Leu Ala Val Lys
                 885                 890                 895    
 Ala Tyr Asn Ser Ala Gly Thr Gly Pro Ser Ser Ala Thr Val Asn Val
             900                 905                 910        
 Thr Thr Arg Lys Pro Pro Pro Ser Gln Pro Pro Gly Asn Ile Ile Trp
         915                 920                 925            
 Asn Ser Ser Asp Ser Lys Ile Ile Leu Asn Trp Asp Gln Val Lys Ala
     930                 935                 940                
 Leu Asp Asn Glu Ser Glu Val Lys Gly Tyr Lys Val Leu Tyr Arg Trp
 945                 950                 955                 960
 Asn Arg Gln Ser Ser Thr Ser Val Ile Glu Thr Asn Lys Thr Ser Val
                 965                 970                 975    
 Glu Leu Ser Leu Pro Phe Asp Glu Asp Tyr Ile Ile Glu Ile Lys Pro
             980                 985                 990        
 Phe Ser Asp Gly Gly Asp Gly Ser Ser Ser Glu Gln Ile Arg Ile Pro
         995                1000                1005            
 Lys Ile Ser Asn Ala Tyr Ala Arg Gly Ser Gly Ala Ser Thr Ser Asn
    1010                1015                1020                
 Ala Cys Thr Leu Ser Ala Ile Ser Thr Ile Met Ile Ser Leu Thr Ala
1025                1030                1035                1040
 Arg Ser Ser Leu
                



      <210> 1349
      <211> 222
      <212> PRT
      <213> Homo sapiens


      <400> 1349
 Met Leu Pro Ser Gln Glu Ala Ser Lys Leu Tyr His Glu His Tyr Met
   1               5                  10                  15    
 Arg Asn Ser Arg Ala Ile Gly Val Leu Trp Ala Ile Phe Thr Ile Cys
              20                  25                  30        
 Phe Ala Ile Val Asn Val Val Cys Phe Ile Gln Pro Tyr Trp Ile Gly
          35                  40                  45            
 Asp Gly Val Asp Thr Pro Gln Ala Gly Tyr Phe Gly Leu Phe His Tyr
      50                  55                  60                
 Cys Ile Gly Asn Gly Phe Ser Arg Glu Leu Thr Cys Arg Gly Ser Phe
  65                  70                  75                  80
 Thr Asp Phe Ser Thr Leu Pro Ser Gly Ala Phe Lys Ala Ala Ser Phe
                  85                  90                  95    
 Phe Ile Gly Leu Ser Met Met Leu Ile Ile Ala Cys Ile Ile Cys Phe
             100                 105                 110        
 Thr Leu Phe Phe Phe Cys Asn Thr Ala Thr Val Tyr Lys Ile Cys Ala
         115                 120                 125            
 Trp Met Gln Leu Thr Ser Ala Ala Cys Leu Val Leu Gly Cys Met Ile
     130                 135                 140                
 Phe Pro Asp Gly Trp Asp Ser Asp Glu Val Lys Arg Met Cys Gly Glu
 145                 150                 155                 160
 Lys Thr Asp Lys Tyr Thr Leu Gly Ala Cys Ser Val Arg Trp Ala Tyr
                 165                 170                 175    
 Ile Leu Ala Ile Ile Gly Ile Leu Asp Ala Leu Ile Leu Ser Phe Leu
             180                 185                 190        
 Ala Phe Val Leu Gly Asn Arg Gln Asp Ser Leu Met Ala Glu Glu Leu
         195                 200                 205            
 Lys Ala Glu Asn Lys Val Leu Leu Ser Gln Tyr Ser Leu Glu
     210                 215                 220        



      <210> 1350
      <211> 405
      <212> PRT
      <213> Homo sapiens


      <400> 1350
 Met Glu Arg Met Leu Pro Leu Leu Ala Leu Gly Leu Leu Ala Ala Gly
   1               5                  10                  15    
 Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu Glu
              20                  25                  30        
 Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu Gly
          35                  40                  45            
 Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu
      50                  55                  60                
 Val Leu Lys Ala Pro Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile
  65                  70                  75                  80
 Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu
                  85                  90                  95    
 Thr Glu Ile Leu Lys Gly Leu Lys Phe Asn Leu Thr Glu Thr Ser Glu
             100                 105                 110        
 Ala Glu Ile His Gln Ser Phe Gln His Leu Leu Arg Thr Leu Asn Gln
         115                 120                 125            
 Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn Ala Met Phe Val Lys
     130                 135                 140                
 Glu Gln Leu Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala Lys Arg Leu
 145                 150                 155                 160
 Tyr Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala
                 165                 170                 175    
 Lys Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile
             180                 185                 190        
 Thr Asp Leu Ile Lys Asp Leu Asp Ser Gln Thr Met Met Val Leu Val
         195                 200                 205            
 Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro Gln
     210                 215                 220                
 Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val Met
 225                 230                 235                 240
 Val Pro Met Met Ser Leu His His Leu Thr Ile Pro Tyr Phe Arg Asp
                 245                 250                 255    
 Glu Glu Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala
             260                 265                 270        
 Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp Lys Met Glu Glu Val Glu
         275                 280                 285            
 Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser Leu Glu
     290                 295                 300                
 Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Arg
 305                 310                 315                 320
 Asp Tyr Asn Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile Glu Glu Ala
                 325                 330                 335    
 Phe Thr Ser Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala Arg Asn Leu
             340                 345                 350        
 Ala Val Ser Gln Val Val His Lys Ala Val Leu Asp Val Phe Glu Glu
         355                 360                 365            
 Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Arg Pro Phe Leu Met Ile
     370                 375                 380                
 Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys Val Thr
 385                 390                 395                 400
 Asn Pro Lys Gln Ala
                 405



      <210> 1351
      <211> 839
      <212> PRT
      <213> Homo sapiens


      <400> 1351
 Met Thr Thr Arg Gln Ala Thr Lys Asp Pro Leu Leu Arg Gly Val Ser
   1               5                  10                  15    
 Pro Thr Pro Ser Lys Ile Pro Val Arg Ser Gln Lys Arg Thr Pro Phe
              20                  25                  30        
 Pro Thr Val Thr Ser Cys Ala Val Asp Gln Glu Asn Gln Asp Pro Arg
          35                  40                  45            
 Arg Trp Val Gln Lys Pro Pro Leu Asn Ile Gln Arg Pro Leu Val Asp
      50                  55                  60                
 Ser Ala Gly Pro Arg Pro Lys Ala Arg His Gln Ala Glu Thr Ser Gln
  65                  70                  75                  80
 Arg Leu Val Gly Ile Ser Gln Pro Arg Asn Pro Leu Glu Glu Leu Arg
                  85                  90                  95    
 Pro Ser Pro Arg Gly Gln Asn Val Gly Pro Gly Pro Pro Ala Gln Thr
             100                 105                 110        
 Glu Ala Pro Gly Thr Ile Glu Phe Val Ala Asp Pro Ala Ala Leu Ala
         115                 120                 125            
 Thr Ile Leu Ser Gly Glu Gly Val Lys Ser Cys His Leu Gly Arg Gln
     130                 135                 140                
 Pro Ser Leu Ala Lys Arg Val Leu Val Arg Gly Ser Gln Gly Gly Thr
 145                 150                 155                 160
 Thr Gln Arg Val Gln Gly Val Arg Ala Ser Ala Tyr Leu Ala Pro Arg
                 165                 170                 175    
 Thr Pro Thr His Arg Leu Asp Pro Ala Arg Ala Ser Cys Phe Ser Arg
             180                 185                 190        
 Leu Glu Gly Pro Gly Pro Arg Gly Arg Thr Leu Cys Pro Gln Arg Leu
         195                 200                 205            
 Gln Ala Leu Ile Ser Pro Ser Gly Pro Ser Phe His Pro Ser Thr Arg
     210                 215                 220                
 Pro Ser Phe Gln Glu Leu Arg Arg Glu Thr Ala Gly Ser Ser Arg Thr
 225                 230                 235                 240
 Ser Val Ser Gln Ala Ser Gly Leu Leu Leu Glu Thr Pro Val Gln Pro
                 245                 250                 255    
 Ala Phe Ser Leu Pro Lys Gly Glu Arg Glu Val Val Thr His Ser Asp
             260                 265                 270        
 Glu Gly Gly Val Ala Ser Leu Gly Leu Ala Gln Arg Val Pro Leu Arg
         275                 280                 285            
 Glu Asn Arg Glu Met Ser His Thr Arg Asp Ser His Asp Ser His Leu
     290                 295                 300                
 Met Pro Ser Pro Ala Pro Val Ala Gln Pro Leu Pro Gly His Val Val
 305                 310                 315                 320
 Pro Cys Pro Ser Pro Phe Gly Arg Ala Gln Arg Val Pro Ser Pro Gly
                 325                 330                 335    
 Pro Pro Thr Leu Thr Ser Tyr Ser Val Leu Arg Arg Leu Thr Val Gln
             340                 345                 350        
 Pro Lys Thr Arg Phe Thr Pro Met Pro Ser Thr Pro Arg Val Gln Gln
         355                 360                 365            
 Ala Gln Trp Leu Arg Gly Val Ser Pro Gln Ser Cys Ser Glu Asp Pro
     370                 375                 380                
 Ala Leu Pro Trp Glu Gln Val Ala Val Arg Leu Phe Asp Gln Glu Ser
 385                 390                 395                 400
 Cys Ile Arg Ser Leu Glu Gly Ser Gly Lys Pro Pro Val Ala Thr Pro
                 405                 410                 415    
 Ser Gly Pro His Ser Asn Arg Thr Pro Ser Leu Gln Glu Val Lys Ile
             420                 425                 430        
 Gln Arg Ile Gly Ile Leu Gln Gln Leu Leu Arg Gln Glu Val Glu Gly
         435                 440                 445            
 Leu Val Gly Gly Gln Cys Val Pro Leu Asn Gly Gly Ser Ser Leu Asp
     450                 455                 460                
 Met Val Glu Leu Gln Pro Leu Leu Thr Glu Ile Ser Arg Thr Leu Asn
 465                 470                 475                 480
 Ala Thr Glu His Asn Ser Gly Thr Ser His Leu Pro Gly Leu Leu Lys
                 485                 490                 495    
 His Ser Gly Leu Pro Lys Pro Cys Leu Pro Glu Glu Cys Gly Glu Pro
             500                 505                 510        
 Gln Pro Cys Pro Pro Ala Glu Pro Gly Pro Pro Glu Ala Phe Cys Arg
         515                 520                 525            
 Ser Glu Pro Glu Ile Pro Glu Pro Ser Leu Gln Glu Gln Leu Glu Val
     530                 535                 540                
 Pro Glu Pro Tyr Pro Pro Ala Glu Pro Arg Pro Leu Glu Ser Cys Cys
 545                 550                 555                 560
 Arg Ser Glu Pro Glu Ile Pro Glu Ser Ser Arg Gln Glu Gln Leu Glu
                 565                 570                 575    
 Glu Gln Leu Glu Val Pro Glu Pro Cys Pro Pro Ala Glu Pro Gly Pro
             580                 585                 590        
 Leu Gln Pro Ser Thr Gln Gly Gln Ser Gly Pro Pro Gly Pro Cys Pro
         595                 600                 605            
 Arg Val Glu Leu Gly Ala Ser Glu Pro Cys Thr Leu Glu His Arg Ser
     610                 615                 620                
 Leu Glu Ser Ser Leu Pro Pro Cys Cys Ser Gln Trp Ala Pro Ala Thr
 625                 630                 635                 640
 Thr Ser Leu Ile Phe Ser Ser Gln Asp Pro Leu Cys Ala Ser Pro Pro
                 645                 650                 655    
 Ile Cys Ser Leu Gln Ser Leu Arg Pro Pro Ala Gly Gln Ala Gly Lys
             660                 665                 670        
 Glu Leu Ala Gly Lys Glu Cys Glu His Lys Arg Ser Ser Pro His Cys
         675                 680                 685            
 Glu Leu His Thr Cys Pro Ala Pro Thr Pro Gly Asn Leu Met Leu Pro
     690                 695                 700                
 His Leu Pro Pro Trp Pro Ser Leu Ala Leu Pro Gln Glu Glu Gly Arg
 705                 710                 715                 720
 Gly Cys Thr Ser Ser Pro Val Leu Leu Ile Gly Leu Ala Val Gly Gly
                 725                 730                 735    
 Gly Gly Gly Glu Asp Ser Thr Trp Trp Lys Tyr Arg Thr Pro Asp Leu
             740                 745                 750        
 Pro Leu Asn Phe Pro Cys Pro Ser Gly Leu Ser Asn Leu Ala Pro Arg
         755                 760                 765            
 Thr Leu Ala Leu Arg Glu Arg Leu Lys Ser Cys Leu Thr Ala Ile His
     770                 775                 780                
 Cys Phe His Glu Ala Arg Leu Asp Asp Glu Cys Ala Phe Tyr Thr Ser
 785                 790                 795                 800
 Arg Ala Pro Pro Ser Gly Pro Thr Arg Val Cys Thr Asn Pro Val Ala
                 805                 810                 815    
 Thr Leu Leu Glu Trp Gln Asp Ala Leu Cys Phe Ile Pro Val Gly Ser
             820                 825                 830        
 Ala Ala Pro Gln Gly Ser Pro
         835                



      <210> 1352
      <211> 318
      <212> PRT
      <213> Homo sapiens


      <400> 1352
 Met Arg Leu Leu Ala Gly Trp Leu Cys Leu Ser Leu Ala Ser Val Trp
   1               5                  10                  15    
 Leu Ala Arg Arg Met Trp Thr Leu Arg Ser Pro Leu Thr Arg Ser Leu
              20                  25                  30        
 Tyr Val Asn Met Thr Ser Gly Pro Gly Gly Pro Ala Ala Ala Ala Gly
          35                  40                  45            
 Gly Arg Lys Glu Asn His Gln Trp Tyr Val Cys Asn Arg Glu Lys Leu
      50                  55                  60                
 Cys Glu Ser Leu Gln Ala Val Phe Val Gln Ser Tyr Leu Asp Gln Gly
  65                  70                  75                  80
 Thr Gln Ile Phe Leu Asn Asn Ser Ile Glu Lys Ser Gly Trp Leu Phe
                  85                  90                  95    
 Ile Gln Leu Tyr His Ser Phe Val Ser Ser Val Phe Ser Leu Phe Met
             100                 105                 110        
 Ser Arg Thr Ser Ile Asn Gly Leu Leu Gly Arg Gly Ser Met Phe Val
         115                 120                 125            
 Phe Ser Pro Asp Gln Phe Gln Arg Leu Leu Lys Ile Asn Pro Asp Trp
     130                 135                 140                
 Lys Thr His Arg Leu Leu Asp Leu Gly Ala Gly Asp Gly Glu Val Thr
 145                 150                 155                 160
 Lys Ile Met Ser Pro His Phe Glu Glu Ile Tyr Ala Thr Glu Leu Ser
                 165                 170                 175    
 Glu Thr Met Ile Trp Gln Leu Gln Lys Lys Lys Tyr Arg Val Leu Gly
             180                 185                 190        
 Ile Asn Glu Trp Gln Asn Thr Gly Phe Gln Tyr Asp Val Ile Ser Cys
         195                 200                 205            
 Leu Asn Leu Leu Asp Arg Cys Asp Gln Pro Leu Thr Leu Leu Lys Asp
     210                 215                 220                
 Ile Arg Ser Val Leu Glu Pro Thr Arg Gly Arg Val Ile Leu Ala Leu
 225                 230                 235                 240
 Val Leu Pro Phe His Pro Tyr Val Glu Asn Val Gly Gly Lys Trp Glu
                 245                 250                 255    
 Lys Pro Ser Glu Ile Leu Glu Ile Lys Gly Gln Asn Trp Glu Glu Gln
             260                 265                 270        
 Val Asn Ser Leu Pro Glu Val Phe Arg Lys Ala Gly Phe Val Ile Glu
         275                 280                 285            
 Ala Phe Thr Arg Leu Pro Tyr Leu Cys Glu Gly Asp Met Tyr Asn Asp
     290                 295                 300                
 Tyr Tyr Val Leu Asp Asp Ala Val Phe Val Leu Lys Pro Val
 305                 310                 315            



      <210> 1353
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 1353
 Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile His Ser
   1               5                  10                  15    
 Met Gly Glu Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Thr
              20                  25                  30        
 Arg Val Leu Asn Gln Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala
          35                  40                  45            
 Thr Val Met Asp Lys Thr Arg Ala Leu Ile Asp Ser Val Ile Pro Lys
      50                  55                  60                
 Gly Ala Gln Ala Cys Gln Ile Cys Ile Thr Tyr Ile Cys Glu Glu Asp
  65                  70                  75                  80
 Ser Tyr Leu Ala Glu Thr Leu Gly Leu Ser Ala Gly Pro Ile Pro Gly
                  85                  90                  95    
 Asn
    



      <210> 1354
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 1354
 Met Gly Ser Ser Val Leu Ser Ile Trp Ile Leu Ser Pro Ser Ile Tyr
   1               5                  10                  15    
 Pro Ile Leu Ser Pro Leu Ala Met Pro Cys Leu Ser Arg Thr Asp Leu
              20                  25                  30        
 Ile Arg Val Arg Arg Ile Gln Gly Ala Trp Pro Ser Glu Gly Thr Ala
          35                  40                  45            
 Ser Ser Ile Arg Gly Trp Val Leu Thr Lys Leu Arg Met Ser Ser Gly
      50                  55                  60                
 Lys Ala Leu Glu Ala Leu Tyr Cys Ile Pro Gly Ala Ala Gln His Pro
  65                  70                  75                  80
 Gly Leu Gly Val Thr Arg Val Trp Ser Gly Arg Thr
                  85                  90        



      <210> 1355
      <211> 238
      <212> PRT
      <213> Homo sapiens


      <400> 1355
 Met Glu Asp Gly Lys Arg Glu Arg Trp Pro Thr Leu Met Glu Arg Leu
   1               5                  10                  15    
 Cys Ser Asp Gly Phe Ala Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His
              20                  25                  30        
 Leu Asn Arg Ile His Arg Ala Val Leu His Gly Asn Leu Glu Lys Leu
          35                  40                  45            
 Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys Arg Asp Arg Lys
      50                  55                  60                
 Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met
  65                  70                  75                  80
 Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg
                  85                  90                  95    
 Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala
             100                 105                 110        
 Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asn Pro Asn Ile Thr Asp
         115                 120                 125            
 Phe Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr
     130                 135                 140                
 Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn Ile Glu Glu Cys
 145                 150                 155                 160
 Ser Lys Cys Glu Tyr Gln Pro Leu Leu Phe Ala Val Ser Arg Arg Lys
                 165                 170                 175    
 Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Val Asn Ala
             180                 185                 190        
 Ile Asp Tyr Leu Gly Arg Ser Ala Leu Ile His Ala Val Thr Leu Gly
         195                 200                 205            
 Glu Lys Asp Ile Val Ile Leu Leu Leu Gln His Asn Ile Asp Val Leu
     210                 215                 220                
 Ser Arg Asp Ala Phe Arg Lys Ile Cys Arg Arg Leu Cys His
 225                 230                 235            



      <210> 1356
      <211> 2388
      <212> PRT
      <213> Homo sapiens


      <400> 1356
 Met Ser Gly Gly Ala Ala Glu Lys Gln Ser Ser Thr Pro Gly Ser Leu
   1               5                  10                  15    
 Phe Leu Ser Pro Pro Ala Pro Ala Pro Lys Asn Gly Ser Ser Ser Asp
              20                  25                  30        
 Ser Ser Val Gly Glu Lys Leu Gly Ala Ala Ala Ala Asp Ala Val Thr
          35                  40                  45            
 Gly Arg Thr Glu Glu Tyr Arg Arg Arg Arg His Thr Met Asp Lys Asp
      50                  55                  60                
 Ser Arg Gly Ala Ala Ala Thr Thr Thr Thr Thr Glu His Arg Phe Phe
  65                  70                  75                  80
 Arg Arg Ser Val Ile Cys Asp Ser Asn Ala Thr Ala Leu Glu Leu Pro
                  85                  90                  95    
 Gly Leu Pro Leu Ser Leu Pro Gln Pro Ser Ile Pro Ala Ala Val Pro
             100                 105                 110        
 Gln Ser Ala Pro Pro Glu Pro His Arg Glu Glu Thr Val Thr Ala Thr
         115                 120                 125            
 Ala Thr Ser Gln Val Ala Gln Gln Pro Pro Ala Ala Ala Ala Pro Gly
     130                 135                 140                
 Glu Gln Ala Val Ala Gly Pro Ala Pro Ser Thr Val Pro Ser Ser Thr
 145                 150                 155                 160
 Ser Lys Asp Arg Pro Val Ser Gln Pro Ser Leu Val Gly Ser Lys Glu
                 165                 170                 175    
 Glu Pro Pro Pro Ala Arg Ser Gly Ser Gly Gly Gly Ser Ala Lys Glu
             180                 185                 190        
 Pro Gln Glu Glu Arg Ser Gln Gln Gln Asp Asp Ile Glu Glu Leu Glu
         195                 200                 205            
 Thr Lys Ala Val Gly Met Ser Asn Asp Gly Arg Phe Leu Lys Phe Asp
     210                 215                 220                
 Ile Glu Ile Gly Arg Gly Ser Phe Lys Thr Val Tyr Lys Gly Leu Asp
 225                 230                 235                 240
 Thr Glu Thr Thr Val Glu Val Ala Trp Cys Glu Leu Gln Asp Arg Lys
                 245                 250                 255    
 Leu Thr Lys Ser Glu Arg Gln Arg Phe Lys Glu Glu Ala Glu Met Leu
             260                 265                 270        
 Lys Gly Leu Gln His Pro Asn Ile Val Arg Phe Tyr Asp Ser Trp Glu
         275                 280                 285            
 Ser Thr Val Lys Gly Lys Lys Cys Ile Val Leu Val Thr Glu Leu Met
     290                 295                 300                
 Thr Ser Gly Thr Leu Lys Thr Tyr Leu Lys Arg Phe Lys Val Met Lys
 305                 310                 315                 320
 Ile Lys Val Leu Arg Ser Trp Cys Arg Gln Ile Leu Lys Gly Leu Gln
                 325                 330                 335    
 Phe Leu His Thr Arg Thr Pro Pro Ile Ile His Arg Asp Leu Lys Cys
             340                 345                 350        
 Asp Asn Ile Phe Ile Thr Gly Pro Thr Gly Ser Val Lys Ile Gly Asp
         355                 360                 365            
 Leu Gly Leu Ala Thr Leu Lys Arg Ala Ser Phe Ala Lys Ser Val Ile
     370                 375                 380                
 Gly Thr Pro Glu Phe Met Ala Pro Glu Met Tyr Glu Glu Lys Tyr Asp
 385                 390                 395                 400
 Glu Ser Val Asp Val Tyr Ala Phe Gly Met Cys Met Leu Glu Met Ala
                 405                 410                 415    
 Thr Ser Glu Tyr Pro Tyr Ser Glu Cys Gln Asn Ala Ala Gln Ile Tyr
             420                 425                 430        
 Arg Arg Val Thr Ser Gly Val Lys Pro Ala Ser Phe Asp Lys Val Ala
         435                 440                 445            
 Ile Pro Glu Val Lys Glu Ile Ile Glu Gly Cys Ile Arg Gln Asn Lys
     450                 455                 460                
 Asp Glu Arg Tyr Ser Ile Lys Asp Leu Leu Asn His Ala Phe Phe Gln
 465                 470                 475                 480
 Glu Glu Thr Gly Val Arg Val Glu Leu Ala Glu Glu Asp Asp Gly Glu
                 485                 490                 495    
 Lys Ile Ala Ile Lys Leu Trp Leu Arg Ile Glu Asp Ile Lys Lys Leu
             500                 505                 510        
 Lys Gly Lys Tyr Lys Asp Asn Glu Ala Ile Glu Phe Ser Phe Asp Leu
         515                 520                 525            
 Glu Arg Asp Val Pro Glu Asp Val Ala Gln Glu Met Val Glu Ser Gly
     530                 535                 540                
 Tyr Val Cys Glu Gly Asp His Lys Thr Met Ala Lys Ala Ile Lys Asp
 545                 550                 555                 560
 Arg Val Ser Leu Ile Lys Arg Lys Arg Glu Gln Arg Gln Leu Val Arg
                 565                 570                 575    
 Glu Glu Gln Glu Lys Lys Lys Gln Glu Glu Ser Ser Leu Lys Gln Gln
             580                 585                 590        
 Val Glu Gln Ser Ser Ala Ser Gln Thr Gly Ile Lys Gln Leu Pro Ser
         595                 600                 605            
 Ala Ser Thr Gly Ile Pro Thr Ala Ser Thr Thr Ser Ala Ser Val Ser
     610                 615                 620                
 Thr Gln Val Glu Pro Glu Glu Pro Glu Ala Asp Gln His Gln Gln Leu
 625                 630                 635                 640
 Gln Tyr Gln Gln Pro Ser Ile Ser Val Leu Ser Asp Gly Thr Val Asp
                 645                 650                 655    
 Ser Gly Gln Gly Ser Ser Val Phe Thr Glu Ser Arg Val Ser Ser Gln
             660                 665                 670        
 Gln Thr Val Ser Tyr Gly Ser Gln His Glu Gln Ala His Ser Thr Gly
         675                 680                 685            
 Thr Val Pro Gly His Ile Pro Ser Thr Val Gln Ala Gln Ser Gln Pro
     690                 695                 700                
 His Gly Val Tyr Pro Pro Ser Ser Val Ala Gln Gly Gln Ser Gln Gly
 705                 710                 715                 720
 Gln Pro Ser Ser Ser Ser Leu Thr Gly Val Ser Ser Ser Gln Pro Ile
                 725                 730                 735    
 Gln His Pro Gln Gln Gln Gln Gly Ile Gln Gln Thr Ala Pro Pro Gln
             740                 745                 750        
 Gln Thr Val Gln Tyr Ser Leu Ser Gln Thr Ser Thr Ser Ser Glu Ala
         755                 760                 765            
 Thr Thr Ala Gln Pro Val Ser Gln Pro Gln Ala Pro Gln Val Leu Pro
     770                 775                 780                
 Gln Val Ser Ala Gly Lys Gln Leu Pro Val Ser Gln Pro Val Pro Thr
 785                 790                 795                 800
 Ile Gln Gly Glu Pro Gln Ile Pro Val Ala Thr Gln Pro Ser Val Val
                 805                 810                 815    
 Pro Val His Ser Gly Ala His Phe Leu Pro Val Gly Gln Pro Leu Pro
             820                 825                 830        
 Thr Pro Leu Leu Pro Gln Tyr Pro Val Ser Gln Ile Pro Ile Ser Thr
         835                 840                 845            
 Pro His Val Ser Thr Ala Gln Thr Gly Phe Ser Ser Leu Pro Ile Thr
     850                 855                 860                
 Met Ala Ala Gly Ile Thr Gln Pro Leu Leu Thr Leu Ala Ser Ser Ala
 865                 870                 875                 880
 Thr Thr Ala Ala Ile Pro Gly Val Ser Thr Val Val Pro Ser Gln Leu
                 885                 890                 895    
 Pro Thr Leu Leu Gln Pro Val Thr Gln Leu Pro Ser Gln Val His Pro
             900                 905                 910        
 Gln Leu Leu Gln Pro Ala Val Gln Ser Met Gly Ile Pro Ala Asn Leu
         915                 920                 925            
 Gly Gln Ala Ala Glu Val Pro Leu Ser Ser Gly Asp Val Leu Tyr Gln
     930                 935                 940                
 Gly Phe Pro Pro Arg Leu Pro Pro Gln Tyr Pro Gly Asp Ser Asn Ile
 945                 950                 955                 960
 Ala Pro Ser Ser Asn Val Ala Ser Val Cys Ile His Ser Thr Val Leu
                 965                 970                 975    
 Ser Pro Pro Met Pro Thr Glu Val Leu Ala Thr Pro Gly Tyr Phe Pro
             980                 985                 990        
 Thr Val Val Gln Pro Tyr Val Glu Ser Asn Leu Leu Val Pro Met Gly
         995                1000                1005            
 Gly Val Gly Gly Gln Val Gln Val Ser Gln Pro Gly Gly Ser Leu Ala
    1010                1015                1020                
 Gln Ala Pro Thr Thr Ser Ser Gln Gln Ala Val Leu Glu Ser Thr Gln
1025                1030                1035                1040
 Gly Val Ser Gln Val Ala Pro Ala Glu Pro Val Ala Val Ala Gln Pro
                1045                1050                1055    
 Gln Ala Thr Gln Pro Thr Thr Leu Ala Ser Ser Val Asp Ser Ala His
            1060                1065                1070        
 Ser Asp Val Ala Ser Gly Met Ser Asp Gly Asn Glu Asn Val Pro Ser
        1075                1080                1085            
 Ser Ser Gly Arg His Glu Gly Arg Thr Thr Lys Arg His Tyr Arg Lys
    1090                1095                1100                
 Ser Val Arg Ser Arg Ser Arg His Glu Lys Thr Ser Arg Pro Lys Leu
1105                1110                1115                1120
 Arg Ile Leu Asn Val Ser Asn Lys Gly Asp Arg Val Val Glu Cys Gln
                1125                1130                1135    
 Leu Glu Thr His Asn Arg Lys Met Val Thr Phe Lys Phe Asp Leu Asp
            1140                1145                1150        
 Gly Asp Asn Pro Glu Glu Ile Ala Thr Ile Met Val Asn Asn Asp Phe
        1155                1160                1165            
 Ile Leu Ala Ile Glu Arg Glu Ser Phe Val Asp Gln Val Arg Glu Ile
    1170                1175                1180                
 Ile Glu Lys Ala Asp Glu Met Leu Ser Glu Asp Val Ser Val Glu Pro
1185                1190                1195                1200
 Glu Gly Asp Gln Gly Leu Glu Ser Leu Gln Gly Lys Asp Asp Tyr Gly
                1205                1210                1215    
 Phe Ser Gly Ser Gln Lys Leu Glu Gly Glu Phe Lys Gln Pro Ile Pro
            1220                1225                1230        
 Ala Ser Ser Met Pro Gln Gln Ile Gly Ile Pro Thr Ser Ser Leu Thr
        1235                1240                1245            
 Gln Val Val His Ser Ala Gly Arg Arg Phe Ile Val Ser Pro Val Pro
    1250                1255                1260                
 Glu Ser Arg Leu Arg Glu Ser Lys Val Phe Pro Ser Glu Ile Thr Asp
1265                1270                1275                1280
 Thr Val Ala Ala Ser Thr Ala Gln Ser Pro Gly Met Asn Leu Ser His
                1285                1290                1295    
 Ser Ala Ser Ser Leu Ser Leu Gln Gln Ala Phe Ser Glu Leu Arg Arg
            1300                1305                1310        
 Ala Gln Met Thr Glu Gly Pro Asn Thr Ala Pro Pro Asn Phe Ser His
        1315                1320                1325            
 Thr Gly Pro Thr Phe Pro Val Val Pro Pro Phe Leu Ser Ser Ile Ala
    1330                1335                1340                
 Gly Val Pro Thr Thr Ala Ala Ala Thr Ala Pro Val Pro Ala Thr Ser
1345                1350                1355                1360
 Ser Pro Pro Asn Asp Ile Ser Thr Ser Val Ile Gln Ser Glu Val Thr
                1365                1370                1375    
 Val Pro Thr Glu Glu Gly Ile Ala Gly Val Ala Thr Ser Thr Gly Val
            1380                1385                1390        
 Val Thr Ser Gly Gly Leu Pro Ile Pro Pro Val Ser Glu Ser Pro Val
        1395                1400                1405            
 Leu Ser Ser Val Val Ser Ser Ile Thr Ile Pro Ala Val Val Ser Ile
    1410                1415                1420                
 Ser Thr Thr Ser Pro Ser Leu Gln Val Pro Thr Ser Thr Ser Glu Ile
1425                1430                1435                1440
 Val Val Ser Ser Thr Ala Leu Tyr Pro Ser Val Thr Val Ser Ala Thr
                1445                1450                1455    
 Ser Ala Ser Ala Gly Gly Ser Thr Ala Thr Pro Gly Pro Lys Pro Pro
            1460                1465                1470        
 Ala Val Val Ser Gln Gln Ala Ala Gly Ser Thr Thr Val Gly Ala Thr
        1475                1480                1485            
 Leu Thr Ser Val Ser Thr Thr Thr Ser Phe Pro Ser Thr Ala Ser Gln
    1490                1495                1500                
 Leu Ser Ile Gln Leu Ser Ser Ser Thr Ser Thr Pro Thr Leu Ala Glu
1505                1510                1515                1520
 Thr Val Val Val Ser Ala His Ser Leu Asp Lys Thr Ser His Ser Ser
                1525                1530                1535    
 Thr Thr Gly Leu Ala Phe Ser Leu Ser Ala Pro Ser Ser Ser Ser Ser
            1540                1545                1550        
 Pro Gly Ala Gly Val Ser Ser Tyr Ile Ser Gln Pro Gly Gly Leu His
        1555                1560                1565            
 Pro Leu Val Ile Pro Ser Val Ile Ala Ser Thr Pro Ile Leu Pro Gln
    1570                1575                1580                
 Ala Ala Gly Pro Thr Ser Thr Pro Leu Leu Pro Gln Val Pro Ser Ile
1585                1590                1595                1600
 Pro Pro Leu Val Gln Pro Val Ala Asn Val Pro Ala Val Gln Gln Thr
                1605                1610                1615    
 Leu Ile His Ser Gln Pro Gln Pro Ala Leu Leu Pro Asn Gln Pro His
            1620                1625                1630        
 Thr His Cys Pro Glu Val Asp Ser Asp Thr Gln Pro Lys Ala Pro Gly
        1635                1640                1645            
 Ile Asp Asp Ile Lys Thr Leu Glu Glu Lys Leu Arg Ser Leu Phe Ser
    1650                1655                1660                
 Glu His Ser Ser Ser Gly Ala Gln His Ala Ser Val Ser Leu Glu Thr
1665                1670                1675                1680
 Ser Leu Val Ile Glu Ser Thr Val Thr Pro Gly Ile Pro Thr Thr Ala
                1685                1690                1695    
 Val Ala Pro Ser Lys Leu Leu Thr Ser Thr Thr Ser Thr Cys Leu Pro
            1700                1705                1710        
 Pro Thr Asn Leu Pro Leu Gly Thr Val Ala Leu Pro Val Thr Pro Val
        1715                1720                1725            
 Val Ile Pro Gly Gln Val Ser Thr Pro Val Ser Thr Thr Thr Ser Gly
    1730                1735                1740                
 Val Lys Pro Gly Thr Ala Pro Ser Lys Pro Pro Leu Thr Lys Ala Pro
1745                1750                1755                1760
 Val Leu Pro Val Gly Thr Glu Leu Pro Ala Gly Thr Leu Pro Ser Glu
                1765                1770                1775    
 Gln Leu Pro Pro Phe Pro Gly Pro Ser Leu Thr Gln Ser Gln Gln Pro
            1780                1785                1790        
 Leu Glu Asp Leu Asp Ala Gln Leu Arg Arg Thr Leu Ser Pro Glu Ile
        1795                1800                1805            
 Ile Thr Val Thr Ser Ala Val Gly Pro Val Ser Met Ala Ala Pro Thr
    1810                1815                1820                
 Ala Ile Thr Glu Ala Gly Thr Gln Pro Gln Lys Gly Val Ser Gln Val
1825                1830                1835                1840
 Lys Glu Gly Pro Val Leu Ala Thr Ser Ser Gly Ala Gly Val Phe Lys
                1845                1850                1855    
 Met Gly Arg Phe Gln Val Ser Val Ala Ala Asp Gly Ala Gln Lys Glu
            1860                1865                1870        
 Gly Lys Asn Lys Ser Glu Asp Ala Lys Ser Val His Phe Glu Ser Ser
        1875                1880                1885            
 Thr Ser Glu Ser Ser Val Leu Ser Ser Ser Ser Pro Glu Ser Thr Leu
    1890                1895                1900                
 Val Lys Pro Glu Pro Asn Gly Ile Thr Ile Pro Gly Ile Ser Ser Asp
1905                1910                1915                1920
 Val Pro Glu Ser Ala His Lys Thr Thr Ala Ser Glu Ala Lys Ser Asp
                1925                1930                1935    
 Thr Gly Gln Pro Thr Lys Val Gly Arg Phe Gln Val Thr Thr Thr Ala
            1940                1945                1950        
 Asn Lys Val Gly Arg Phe Ser Val Ser Lys Thr Glu Asp Lys Ile Thr
        1955                1960                1965            
 Asp Thr Lys Lys Glu Gly Pro Val Ala Ser Pro Pro Phe Met Asp Leu
    1970                1975                1980                
 Glu Gln Ala Val Leu Pro Ala Val Ile Pro Lys Lys Glu Lys Pro Glu
1985                1990                1995                2000
 Leu Ser Glu Pro Ser His Leu Asn Gly Pro Ser Ser Asp Pro Glu Ala
                2005                2010                2015    
 Ala Phe Leu Ser Arg Asp Val Asp Asp Gly Ser Gly Ser Pro His Ser
            2020                2025                2030        
 Pro His Gln Leu Ser Ser Lys Ser Leu Pro Ser Gln Asn Leu Ser Gln
        2035                2040                2045            
 Ser Leu Ser Asn Ser Phe Asn Ser Ser Tyr Met Ser Ser Asp Asn Glu
    2050                2055                2060                
 Ser Asp Ile Glu Asp Glu Asp Leu Lys Leu Glu Leu Arg Arg Leu Arg
2065                2070                2075                2080
 Asp Lys His Leu Lys Glu Ile Gln Asp Leu Gln Ser Arg Gln Lys His
                2085                2090                2095    
 Glu Ile Glu Ser Leu Tyr Thr Lys Leu Gly Lys Val Pro Pro Ala Val
            2100                2105                2110        
 Ile Ile Pro Pro Ala Ala Pro Leu Ser Gly Arg Arg Arg Arg Pro Thr
        2115                2120                2125            
 Lys Ser Lys Gly Ser Lys Ser Ser Arg Ser Ser Ser Leu Gly Asn Lys
    2130                2135                2140                
 Ser Pro Gln Leu Ser Gly Asn Leu Ser Gly Gln Ser Ala Ala Ser Val
2145                2150                2155                2160
 Leu His Pro Gln Gln Thr Leu His Pro Pro Gly Asn Ile Pro Glu Ser
                2165                2170                2175    
 Gly Gln Asn Gln Leu Leu Gln Pro Leu Lys Pro Ser Pro Ser Ser Asp
            2180                2185                2190        
 Asn Leu Tyr Ser Ala Phe Thr Ser Asp Gly Ala Ile Ser Val Pro Ser
        2195                2200                2205            
 Leu Ser Ala Pro Gly Gln Gly Thr Ser Ser Thr Asn Thr Val Gly Ala
    2210                2215                2220                
 Thr Val Asn Ser Gln Ala Ala Gln Ala Gln Pro Pro Ala Met Thr Ser
2225                2230                2235                2240
 Ser Arg Lys Gly Thr Phe Thr Asp Asp Leu His Lys Leu Val Asp Asn
                2245                2250                2255    
 Trp Ala Arg Asp Ala Met Asn Leu Ser Gly Arg Arg Gly Ser Lys Gly
            2260                2265                2270        
 His Met Asn Tyr Glu Gly Pro Gly Met Ala Arg Lys Phe Ser Ala Pro
        2275                2280                2285            
 Gly Gln Leu Cys Ile Ser Met Thr Ser Asn Leu Gly Gly Ser Ala Pro
    2290                2295                2300                
 Ile Ser Ala Ala Ser Ala Thr Ser Leu Gly His Phe Thr Lys Ser Met
2305                2310                2315                2320
 Cys Pro Pro Gln Gln Tyr Gly Phe Pro Ala Thr Pro Phe Gly Ala Gln
                2325                2330                2335    
 Trp Ser Gly Thr Gly Gly Pro Ala Pro Gln Pro Leu Gly Gln Phe Thr
            2340                2345                2350        
 Thr Val Asp Asn Ser Leu Leu Ala Glu Phe Gln His Pro Ala Ile Cys
        2355                2360                2365            
 Arg His Ser Thr Arg Thr Thr His Gln Gly His Pro Asn Lys Arg Asn
    2370                2375                2380                
 His Ile Glu Thr
2385            



      <210> 1357
      <211> 1981
      <212> PRT
      <213> Homo sapiens


      <400> 1357
 Met Asp Ile Lys Lys Lys Asp Phe Cys Ser Val Phe Val Ile Ile Asn
   1               5                  10                  15    
 Ser His Cys Cys Cys Cys Pro Gln Lys Asp Cys Ile Asn Glu Gly Val
              20                  25                  30        
 Lys Pro Ala Ser Phe Asp Lys Val Ala Ile Pro Glu Val Lys Glu Ile
          35                  40                  45            
 Ile Glu Gly Cys Ile Arg Gln Asn Lys Asp Glu Arg Tyr Ser Ile Lys
      50                  55                  60                
 Asp Leu Leu Asn His Ala Phe Phe Gln Glu Glu Thr Gly Val Arg Val
  65                  70                  75                  80
 Glu Leu Ala Glu Glu Asp Asp Gly Glu Lys Ile Ala Ile Lys Leu Trp
                  85                  90                  95    
 Leu Arg Ile Glu Asp Ile Lys Lys Leu Lys Gly Lys Tyr Lys Asp Asn
             100                 105                 110        
 Glu Ala Ile Glu Phe Ser Phe Asp Leu Glu Arg Asp Val Pro Glu Asp
         115                 120                 125            
 Val Ala Gln Glu Met Val Glu Ser Gly Tyr Val Cys Glu Gly Asp His
     130                 135                 140                
 Lys Thr Met Ala Lys Ala Ile Lys Asp Arg Val Ser Leu Ile Lys Arg
 145                 150                 155                 160
 Lys Arg Glu Gln Arg Gln Leu Val Arg Glu Glu Gln Glu Lys Lys Lys
                 165                 170                 175    
 Gln Glu Glu Ser Ser Leu Lys Gln Gln Val Glu Gln Ser Ser Ala Ser
             180                 185                 190        
 Gln Thr Gly Ile Lys Gln Leu Pro Ser Ala Ser Thr Gly Ile Pro Thr
         195                 200                 205            
 Ala Ser Thr Thr Ser Ala Ser Val Ser Thr Gln Val Glu Pro Glu Glu
     210                 215                 220                
 Pro Glu Ala Asp Gln His Gln Gln Leu Gln Tyr Gln Gln Pro Ser Ile
 225                 230                 235                 240
 Ser Val Leu Ser Asp Gly Thr Val Asp Ser Gly Gln Gly Ser Ser Val
                 245                 250                 255    
 Phe Thr Glu Ser Arg Val Ser Ser Gln Gln Thr Val Ser Tyr Gly Ser
             260                 265                 270        
 Gln His Glu Gln Ala His Ser Thr Gly Thr Val Pro Gly His Ile Pro
         275                 280                 285            
 Ser Thr Val Gln Ala Gln Ser Gln Pro His Gly Val Tyr Pro Pro Ser
     290                 295                 300                
 Ser Val Ala Gln Gly Gln Ser Gln Gly Gln Pro Ser Ser Ser Ser Leu
 305                 310                 315                 320
 Thr Gly Val Ser Ser Ser Gln Pro Ile Gln His Pro Gln Gln Gln Gln
                 325                 330                 335    
 Gly Ile Gln Gln Thr Ala Pro Pro Gln Gln Thr Val Gln Tyr Ser Leu
             340                 345                 350        
 Ser Gln Thr Ser Thr Ser Ser Glu Ala Thr Thr Ala Gln Pro Val Ser
         355                 360                 365            
 Gln Pro Gln Ala Pro Gln Val Leu Pro Gln Val Ser Ala Gly Lys Gln
     370                 375                 380                
 Leu Pro Val Ser Gln Pro Val Pro Thr Ile Gln Gly Glu Pro Gln Ile
 385                 390                 395                 400
 Pro Val Ala Thr Gln Pro Ser Val Val Pro Val His Ser Gly Ala His
                 405                 410                 415    
 Phe Leu Pro Val Gly Gln Pro Leu Pro Thr Pro Leu Leu Pro Gln Tyr
             420                 425                 430        
 Pro Val Ser Gln Ile Pro Ile Ser Thr Pro His Val Ser Thr Ala Gln
         435                 440                 445            
 Thr Gly Phe Ser Ser Leu Pro Ile Thr Met Ala Ala Gly Ile Thr Gln
     450                 455                 460                
 Pro Leu Leu Thr Leu Ala Ser Ser Ala Thr Thr Ala Ala Ile Pro Gly
 465                 470                 475                 480
 Val Ser Thr Val Val Pro Ser Gln Leu Pro Thr Leu Leu Gln Pro Val
                 485                 490                 495    
 Thr Gln Leu Pro Ser Gln Val His Pro Gln Leu Leu Gln Pro Ala Val
             500                 505                 510        
 Gln Ser Met Gly Ile Pro Ala Asn Leu Gly Gln Ala Ala Glu Val Pro
         515                 520                 525            
 Leu Ser Ser Gly Asp Val Leu Tyr Gln Gly Phe Pro Pro Arg Leu Pro
     530                 535                 540                
 Pro Gln Tyr Pro Gly Asp Ser Asn Ile Ala Pro Ser Ser Asn Val Ala
 545                 550                 555                 560
 Ser Val Cys Ile His Ser Thr Val Leu Ser Pro Pro Met Pro Thr Glu
                 565                 570                 575    
 Val Leu Ala Thr Pro Gly Tyr Phe Pro Thr Val Val Gln Pro Tyr Val
             580                 585                 590        
 Glu Ser Asn Leu Leu Val Pro Met Gly Gly Val Gly Gly Gln Val Gln
         595                 600                 605            
 Val Ser Gln Pro Gly Gly Ser Leu Ala Gln Ala Pro Thr Thr Ser Ser
     610                 615                 620                
 Gln Gln Ala Val Leu Glu Ser Thr Gln Gly Val Ser Gln Val Ala Pro
 625                 630                 635                 640
 Ala Glu Pro Val Ala Val Ala Gln Pro Gln Ala Thr Gln Pro Thr Thr
                 645                 650                 655    
 Leu Ala Ser Ser Val Asp Ser Ala His Ser Asp Val Ala Ser Gly Met
             660                 665                 670        
 Ser Asp Gly Asn Glu Asn Val Pro Ser Ser Ser Gly Arg His Glu Gly
         675                 680                 685            
 Arg Thr Thr Lys Arg His Tyr Arg Lys Ser Val Arg Ser Arg Ser Arg
     690                 695                 700                
 His Glu Lys Thr Ser Arg Pro Lys Leu Arg Ile Leu Asn Val Ser Asn
 705                 710                 715                 720
 Lys Gly Asp Arg Val Val Glu Cys Gln Leu Glu Thr His Asn Arg Lys
                 725                 730                 735    
 Met Val Thr Phe Lys Phe Asp Leu Asp Gly Asp Asn Pro Glu Glu Ile
             740                 745                 750        
 Ala Thr Ile Met Val Asn Asn Asp Phe Ile Leu Ala Ile Glu Arg Glu
         755                 760                 765            
 Ser Phe Val Asp Gln Val Arg Glu Ile Ile Glu Lys Ala Asp Glu Met
     770                 775                 780                
 Leu Ser Glu Asp Val Ser Val Glu Pro Glu Gly Asp Gln Gly Leu Glu
 785                 790                 795                 800
 Ser Leu Gln Gly Lys Asp Asp Tyr Gly Phe Ser Gly Ser Gln Lys Leu
                 805                 810                 815    
 Glu Gly Glu Phe Lys Gln Pro Ile Pro Ala Ser Ser Met Pro Gln Gln
             820                 825                 830        
 Ile Gly Ile Pro Thr Ser Ser Leu Thr Gln Val Val His Ser Ala Gly
         835                 840                 845            
 Arg Arg Phe Ile Val Ser Pro Val Pro Glu Ser Arg Leu Arg Glu Ser
     850                 855                 860                
 Lys Val Phe Pro Ser Glu Ile Thr Asp Thr Val Ala Ala Ser Thr Ala
 865                 870                 875                 880
 Gln Ser Pro Gly Met Asn Leu Ser His Ser Ala Ser Ser Leu Ser Leu
                 885                 890                 895    
 Gln Gln Ala Phe Ser Glu Leu Arg Arg Ala Gln Met Thr Glu Gly Pro
             900                 905                 910        
 Asn Thr Ala Pro Pro Asn Phe Ser His Thr Gly Pro Thr Phe Pro Val
         915                 920                 925            
 Val Pro Pro Phe Leu Ser Ser Ile Ala Gly Val Pro Thr Thr Ala Ala
     930                 935                 940                
 Ala Thr Ala Pro Val Pro Ala Thr Ser Ser Pro Pro Asn Asp Ile Ser
 945                 950                 955                 960
 Thr Ser Val Ile Gln Ser Glu Val Thr Val Pro Thr Glu Glu Gly Ile
                 965                 970                 975    
 Ala Gly Val Ala Thr Ser Thr Gly Val Val Thr Ser Gly Gly Leu Pro
             980                 985                 990        
 Ile Pro Pro Val Ser Glu Ser Pro Val Leu Ser Ser Val Val Ser Ser
         995                1000                1005            
 Ile Thr Ile Pro Ala Val Val Ser Ile Ser Thr Thr Ser Pro Ser Leu
    1010                1015                1020                
 Gln Val Pro Thr Ser Thr Ser Glu Ile Val Val Ser Ser Thr Ala Leu
1025                1030                1035                1040
 Tyr Pro Ser Val Thr Val Ser Ala Thr Ser Ala Ser Ala Gly Gly Ser
                1045                1050                1055    
 Thr Ala Thr Pro Gly Pro Lys Pro Pro Ala Val Val Ser Gln Gln Ala
            1060                1065                1070        
 Ala Gly Ser Thr Thr Val Gly Ala Thr Leu Thr Ser Val Ser Thr Thr
        1075                1080                1085            
 Thr Ser Phe Pro Ser Thr Ala Ser Gln Leu Ser Ile Gln Leu Ser Ser
    1090                1095                1100                
 Ser Thr Ser Thr Pro Thr Leu Ala Glu Thr Val Val Val Ser Ala His
1105                1110                1115                1120
 Ser Leu Asp Lys Thr Ser His Ser Ser Thr Thr Gly Leu Ala Phe Ser
                1125                1130                1135    
 Leu Ser Ala Pro Ser Ser Ser Ser Ser Pro Gly Ala Gly Val Ser Ser
            1140                1145                1150        
 Tyr Ile Ser Gln Pro Gly Gly Leu His Pro Leu Val Ile Pro Ser Val
        1155                1160                1165            
 Ile Ala Ser Thr Pro Ile Leu Pro Gln Ala Ala Gly Pro Thr Ser Thr
    1170                1175                1180                
 Pro Leu Leu Pro Gln Val Pro Ser Ile Pro Pro Leu Val Gln Pro Val
1185                1190                1195                1200
 Ala Asn Val Pro Ala Val Gln Gln Thr Leu Ile His Ser Gln Pro Gln
                1205                1210                1215    
 Pro Ala Leu Leu Pro Asn Gln Pro His Thr His Cys Pro Glu Val Asp
            1220                1225                1230        
 Ser Asp Thr Gln Pro Lys Ala Pro Gly Ile Asp Asp Ile Lys Thr Leu
        1235                1240                1245            
 Glu Glu Lys Leu Arg Ser Leu Phe Ser Glu His Ser Ser Ser Gly Ala
    1250                1255                1260                
 Gln His Ala Ser Val Ser Leu Glu Thr Ser Leu Val Ile Glu Ser Thr
1265                1270                1275                1280
 Val Thr Pro Gly Ile Pro Thr Thr Ala Val Ala Pro Ser Lys Leu Leu
                1285                1290                1295    
 Thr Ser Thr Thr Ser Thr Cys Leu Pro Pro Thr Asn Leu Pro Leu Gly
            1300                1305                1310        
 Thr Val Ala Leu Pro Val Thr Pro Val Val Ile Pro Gly Gln Val Ser
        1315                1320                1325            
 Thr Pro Val Ser Thr Thr Thr Ser Gly Val Lys Pro Gly Thr Ala Pro
    1330                1335                1340                
 Ser Lys Pro Pro Leu Thr Lys Ala Pro Val Leu Pro Val Gly Thr Glu
1345                1350                1355                1360
 Leu Pro Ala Gly Thr Leu Pro Ser Glu Gln Leu Pro Pro Phe Pro Gly
                1365                1370                1375    
 Pro Ser Leu Thr Gln Ser Gln Gln Pro Leu Glu Asp Leu Asp Ala Gln
            1380                1385                1390        
 Leu Arg Arg Thr Leu Ser Pro Glu Ile Ile Thr Val Thr Ser Ala Val
        1395                1400                1405            
 Gly Pro Val Ser Met Ala Ala Pro Thr Ala Ile Thr Glu Ala Gly Thr
    1410                1415                1420                
 Gln Pro Gln Lys Gly Val Ser Gln Val Lys Glu Gly Pro Val Leu Ala
1425                1430                1435                1440
 Thr Ser Ser Gly Ala Gly Val Phe Lys Met Gly Arg Phe Gln Val Ser
                1445                1450                1455    
 Val Ala Ala Asp Gly Ala Gln Lys Glu Gly Lys Asn Lys Ser Glu Asp
            1460                1465                1470        
 Ala Lys Ser Val His Phe Glu Ser Ser Thr Ser Glu Ser Ser Val Leu
        1475                1480                1485            
 Ser Ser Ser Ser Pro Glu Ser Thr Leu Val Lys Pro Glu Pro Asn Gly
    1490                1495                1500                
 Ile Thr Ile Pro Gly Ile Ser Ser Asp Val Pro Glu Ser Ala His Lys
1505                1510                1515                1520
 Thr Thr Ala Ser Glu Ala Lys Ser Asp Thr Gly Gln Pro Thr Lys Val
                1525                1530                1535    
 Gly Arg Phe Gln Val Thr Thr Thr Ala Asn Lys Val Gly Arg Phe Ser
            1540                1545                1550        
 Val Ser Lys Thr Glu Asp Lys Ile Thr Asp Thr Lys Lys Glu Gly Pro
        1555                1560                1565            
 Val Ala Ser Pro Pro Phe Met Asp Leu Glu Gln Ala Val Leu Pro Ala
    1570                1575                1580                
 Val Ile Pro Lys Lys Glu Lys Pro Glu Leu Ser Glu Pro Ser His Leu
1585                1590                1595                1600
 Asn Gly Pro Ser Ser Asp Pro Glu Ala Ala Phe Leu Ser Arg Asp Val
                1605                1610                1615    
 Asp Asp Gly Ser Gly Ser Pro His Ser Pro His Gln Leu Ser Ser Lys
            1620                1625                1630        
 Ser Leu Pro Ser Gln Asn Leu Ser Gln Ser Leu Ser Asn Ser Phe Asn
        1635                1640                1645            
 Ser Ser Tyr Met Ser Ser Asp Asn Glu Ser Asp Ile Glu Asp Glu Asp
    1650                1655                1660                
 Leu Lys Leu Glu Leu Arg Arg Leu Arg Asp Lys His Leu Lys Glu Ile
1665                1670                1675                1680
 Gln Asp Leu Gln Ser Arg Gln Lys His Glu Ile Glu Ser Leu Tyr Thr
                1685                1690                1695    
 Lys Leu Gly Lys Val Pro Pro Ala Val Ile Ile Pro Pro Ala Ala Pro
            1700                1705                1710        
 Leu Ser Gly Arg Arg Arg Arg Pro Thr Lys Ser Lys Gly Ser Lys Ser
        1715                1720                1725            
 Ser Arg Ser Ser Ser Leu Gly Asn Lys Ser Pro Gln Leu Ser Gly Asn
    1730                1735                1740                
 Leu Ser Gly Gln Ser Ala Ala Ser Val Leu His Pro Gln Gln Thr Leu
1745                1750                1755                1760
 His Pro Pro Gly Asn Ile Pro Glu Ser Gly Gln Asn Gln Leu Leu Gln
                1765                1770                1775    
 Pro Leu Lys Pro Ser Pro Ser Ser Asp Asn Leu Tyr Ser Ala Phe Thr
            1780                1785                1790        
 Ser Asp Gly Ala Ile Ser Val Pro Ser Leu Ser Ala Pro Gly Gln Gly
        1795                1800                1805            
 Thr Ser Ser Thr Asn Thr Val Gly Ala Thr Val Asn Ser Gln Ala Ala
    1810                1815                1820                
 Gln Ala Gln Pro Pro Ala Met Thr Ser Ser Arg Lys Gly Thr Phe Thr
1825                1830                1835                1840
 Asp Asp Leu His Lys Leu Val Asp Asn Trp Ala Arg Asp Ala Met Asn
                1845                1850                1855    
 Leu Ser Gly Arg Arg Gly Ser Lys Gly His Met Asn Tyr Glu Gly Pro
            1860                1865                1870        
 Gly Met Ala Arg Lys Phe Ser Ala Pro Gly Gln Leu Cys Ile Ser Met
        1875                1880                1885            
 Thr Ser Asn Leu Gly Gly Ser Ala Pro Ile Ser Ala Ala Ser Ala Thr
    1890                1895                1900                
 Ser Leu Gly His Phe Thr Lys Ser Met Cys Pro Pro Gln Gln Tyr Gly
1905                1910                1915                1920
 Phe Pro Ala Thr Pro Phe Gly Ala Gln Trp Ser Gly Thr Gly Gly Pro
                1925                1930                1935    
 Ala Pro Gln Pro Leu Gly Gln Phe Thr Thr Val Asp Asn Ser Leu Leu
            1940                1945                1950        
 Ala Glu Phe Gln His Pro Ala Ile Cys Arg His Ser Thr Arg Thr Thr
        1955                1960                1965            
 His Gln Gly His Pro Asn Lys Arg Asn His Ile Glu Thr
    1970                1975                1980    



      <210> 1358
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 1358
 Met Leu Phe Val Leu Val Leu Val Phe Ala Ile Cys Trp Ala Pro Phe
   1               5                  10                  15    
 His Ile Asp Arg Leu Phe Phe Ser Phe Val Glu Glu Trp Ser Glu Ser
              20                  25                  30        
 Leu Ala Ala Val Phe Asn Leu Val His Val Val Ser Gly Val Phe Phe
          35                  40                  45            
 Tyr Leu Ser Ser Ala Val Asn Pro Ile Ile Tyr Asn Leu Leu Ser Arg
      50                  55                  60                
 Arg Phe Gln Ala Ala Phe Gln Asn Val Ile Ser Ser Phe His Lys Gln
  65                  70                  75                  80
 Trp His Ser Gln His Asp Pro Gln Leu Pro Pro Ala Gln Arg Asn Ile
                  85                  90                  95    
 Phe Leu Thr Glu Cys His Phe Val Glu Leu Thr Glu Asp Ile Gly Pro
             100                 105                 110        
 Gln Phe Pro Cys Gln Ser Ser Met His Asn Ser His Leu Pro Thr Ala
         115                 120                 125            
 Leu Ser Ser Glu Gln Met Ser Arg Thr Asn Tyr Gln Ser Phe His Phe
     130                 135                 140                
 Asn Lys Thr
 145        



      <210> 1359
      <211> 593
      <212> PRT
      <213> Homo sapiens


      <400> 1359
 Met Leu Arg Thr Ser Val Leu Arg Leu Leu Gly Arg Thr Gly Ala Ser
   1               5                  10                  15    
 Arg Leu Ser Leu Leu Glu Asp Phe Gly Pro Arg Tyr Tyr Ser Ser Gly
              20                  25                  30        
 Ser Leu Ser Ala Gly Asp Asp Ala Cys Asp Val Arg Ala Tyr Phe Thr
          35                  40                  45            
 Thr Pro Ile Phe Tyr Val Asn Ala Ala Pro His Ile Gly His Leu Tyr
      50                  55                  60                
 Ser Ala Leu Leu Ala Asp Ala Leu Cys Arg His Arg Arg Leu Arg Gly
  65                  70                  75                  80
 Pro Ser Thr Ala Ala Thr Arg Phe Ser Thr Gly Thr Asp Glu His Gly
                  85                  90                  95    
 Leu Lys Ile Gln Gln Ala Ala Ala Thr Ala Gly Leu Ala Pro Thr Glu
             100                 105                 110        
 Leu Cys Asp Arg Val Ser Glu Gln Phe Gln Gln Leu Phe Gln Glu Ala
         115                 120                 125            
 Gly Ile Ser Cys Thr Asp Phe Ile Arg Thr Thr Glu Ala Arg His Arg
     130                 135                 140                
 Val Ala Val Gln His Phe Trp Gly Val Leu Lys Ser Arg Gly Leu Leu
 145                 150                 155                 160
 Tyr Lys Gly Val Tyr Glu Gly Arg Tyr Ser Ala Ser Asp Glu Cys Phe
                 165                 170                 175    
 Leu Pro Glu Ala Lys Val Thr Gln Gln Arg Ala His Arg Gly Ile Arg
             180                 185                 190        
 Phe Leu Tyr Leu Leu Glu Ser Gly His Pro Val Ser Trp Thr Lys Glu
         195                 200                 205            
 Glu Asn Tyr Ile Phe Arg Leu Ser Gln Phe Arg Lys Pro Leu Gln Arg
     210                 215                 220                
 Trp Leu Arg Gly Asn Pro Gln Ala Ile Thr Pro Glu Pro Phe His His
 225                 230                 235                 240
 Val Val Leu Gln Trp Leu Asp Glu Glu Leu Pro Asp Leu Ser Val Ser
                 245                 250                 255    
 Arg Arg Ser Ser His Leu His Trp Gly Ile Pro Val Pro Gly Asp Asp
             260                 265                 270        
 Ser Gln Thr Ile Tyr Val Trp Leu Asp Ala Leu Val Asn Tyr Leu Thr
         275                 280                 285            
 Val Ile Gly Tyr Pro Asn Ala Glu Phe Lys Ser Trp Trp Pro Ala Thr
     290                 295                 300                
 Ser His Ile Ile Gly Lys Asp Ile Leu Lys Phe His Ala Ile Tyr Trp
 305                 310                 315                 320
 Pro Ala Phe Leu Leu Gly Ala Gly Met Ser Pro Pro Gln Arg Ile Cys
                 325                 330                 335    
 Val His Ser His Trp Thr Val Cys Gly Gln Lys Met Ser Lys Ser Leu
             340                 345                 350        
 Gly Asn Val Val Asp Pro Arg Thr Cys Leu Asn Arg Tyr Thr Val Asp
         355                 360                 365            
 Gly Phe Arg Tyr Phe Leu Leu Arg Gln Gly Val Pro Asn Trp Asp Cys
     370                 375                 380                
 Asp Tyr Tyr Asp Glu Lys Val Val Lys Leu Leu Asn Ser Glu Leu Ala
 385                 390                 395                 400
 Asp Ala Leu Gly Gly Leu Leu Asn Arg Cys Thr Ala Lys Arg Ile Asn
                 405                 410                 415    
 Pro Ser Glu Thr Tyr Pro Ala Phe Cys Thr Thr Cys Phe Pro Ser Glu
             420                 425                 430        
 Pro Gly Leu Val Gly Pro Ser Val Arg Ala Gln Ala Glu Asp Tyr Ala
         435                 440                 445            
 Leu Val Ser Ala Val Ala Thr Leu Pro Lys Gln Val Ala Asp His Tyr
     450                 455                 460                
 Asp Asn Phe Arg Ile Tyr Lys Ala Leu Glu Ala Val Ser Ser Cys Val
 465                 470                 475                 480
 Arg Gln Thr Asn Gly Phe Val Gln Arg His Ala Pro Trp Lys Leu Asn
                 485                 490                 495    
 Trp Lys Ser Pro Val Asp Ala Pro Trp Leu Gly Thr Val Leu His Val
             500                 505                 510        
 Ala Leu Glu Cys Leu Arg Val Phe Gly Thr Leu Leu Gln Pro Val Thr
         515                 520                 525            
 Pro Ser Leu Ala Asp Lys Leu Leu Ser Arg Leu Gly Val Ser Ala Ser
     530                 535                 540                
 Glu Arg Ser Leu Gly Glu Leu Tyr Phe Leu Pro Arg Phe Tyr Gly His
 545                 550                 555                 560
 Pro Cys Pro Phe Glu Gly Arg Arg Leu Gly Pro Glu Thr Gly Leu Leu
                 565                 570                 575    
 Phe Pro Arg Leu Asp Gln Ser Arg Thr Trp Leu Val Lys Ala His Arg
             580                 585                 590        
 Thr
    



      <210> 1360
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 1360
 Met Met Ile Leu Gln Val Ser Gly Gly Pro Trp Thr Val Ala Leu Thr
   1               5                  10                  15    
 Ala Leu Leu Met Val Leu Leu Ile Ser Val Val Gln Ser Arg Ala Thr
              20                  25                  30        
 Pro Glu Asn Ser Val Tyr Gln Glu Arg Gln Glu Cys Tyr Ala Phe Asn
          35                  40                  45            
 Gly Thr Gln Arg Val Val Asp Gly Leu Ile Tyr Asn Arg Glu Glu Tyr
      50                  55                  60                
 Val His Phe Asp Ser Ala Val Gly Glu Phe Leu Ala Val Met Glu Leu
  65                  70                  75                  80
 Gly Arg Pro Ile Gly Glu Tyr Phe Asn Ser Gln Lys Asp Phe Met Glu
                  85                  90                  95    
 Arg Lys Arg Ala Glu Val Asp Lys Val Cys Arg His Lys Tyr Glu Leu
             100                 105                 110        
 Met Glu Pro Leu Ile Arg Gln Arg Arg Gly Asp Val Thr Ile Thr Ala
         115                 120                 125            
 Val Arg Gly Cys Trp Thr Thr Ile Leu Ser Gly Tyr Phe Leu Leu Lys
     130                 135                 140                
 Arg Gly Val Val Ser Gly Gly Cys Ser Trp Gly Ser Ser
 145                 150                 155        



      <210> 1361
      <211> 208
      <212> PRT
      <213> Homo sapiens


      <400> 1361
 Met Ala Leu Leu Leu Cys Leu Val Cys Leu Thr Ala Ala Leu Ala His
   1               5                  10                  15    
 Gly Cys Leu His Cys His Ser Asn Phe Ser Lys Lys Phe Ser Phe Tyr
              20                  25                  30        
 Arg His His Val Asn Phe Lys Ser Trp Trp Val Gly Asp Ile Pro Val
          35                  40                  45            
 Ser Gly Ala Leu Leu Thr Asp Trp Ser Asp Asp Thr Met Lys Glu Leu
      50                  55                  60                
 His Leu Ala Ile Pro Ala Lys Ile Thr Arg Glu Lys Leu Asp Gln Val
  65                  70                  75                  80
 Ala Thr Ala Val Tyr Gln Met Met Asp Gln Leu Tyr Gln Gly Lys Met
                  85                  90                  95    
 Tyr Phe Pro Gly Tyr Phe Pro Asn Glu Leu Arg Asn Ile Phe Arg Glu
             100                 105                 110        
 Gln Val His Leu Ile Gln Asn Ala Ile Ile Glu Ser Arg Ile Asp Cys
         115                 120                 125            
 Gln His Arg Cys Gly Ile Phe Gln Tyr Glu Thr Ile Ser Cys Asn Asn
     130                 135                 140                
 Cys Thr Asp Ser His Val Ala Cys Phe Gly Tyr Asn Cys Glu Ser Ser
 145                 150                 155                 160
 Ala Gln Trp Lys Ser Ala Val Gln Gly Leu Leu Asn Tyr Ile Asn Asn
                 165                 170                 175    
 Trp His Asn Leu Val Ser Pro Ala Leu Arg Cys Leu Glu Pro Pro His
             180                 185                 190        
 Leu Ala Asn Leu Thr Leu Glu Asp Ala Ala Glu Cys Leu Lys Gln His
         195                 200                 205            





      <210> 1362
      <211> 214
      <212> PRT
      <213> Homo sapiens


      <400> 1362
 Met Ala Leu Leu Leu Cys Leu Val Cys Leu Thr Ala Ala Leu Ala His
   1               5                  10                  15    
 Gly Cys Leu His Cys His Ser Asn Phe Ser Lys Lys Phe Ser Phe Tyr
              20                  25                  30        
 Arg His His Val Asn Phe Lys Ser Trp Trp Val Gly Asp Ile Pro Val
          35                  40                  45            
 Ser Gly Ala Leu Leu Thr Asp Trp Ser Asp Asp Thr Met Lys Glu Leu
      50                  55                  60                
 His Leu Ala Ile Pro Ala Lys Ile Thr Arg Glu Lys Leu Asp Gln Val
  65                  70                  75                  80
 Ala Thr Ala Val Tyr Gln Met Met Asp Gln Leu Tyr Gln Gly Lys Met
                  85                  90                  95    
 Tyr Phe Pro Gly Tyr Phe Pro Asn Glu Leu Arg Asn Ile Phe Arg Glu
             100                 105                 110        
 Gln Val His Leu Ile Gln Asn Ala Ile Ile Glu Ser Arg Ile Asp Cys
         115                 120                 125            
 Gln His Arg Cys Gly Ile Phe Gln Tyr Glu Thr Ile Ser Cys Asn Asn
     130                 135                 140                
 Cys Thr Asp Ser His Val Ala Cys Phe Gly Tyr Asn Cys Glu Ser Ser
 145                 150                 155                 160
 Ala Gln Trp Lys Ser Ala Val Gln Gly Leu Leu Asn Tyr Ile Asn Asn
                 165                 170                 175    
 Trp His Lys Gln Asp Thr Ser Met Ser Leu Val Ser Pro Ala Leu Arg
             180                 185                 190        
 Cys Leu Glu Pro Pro His Leu Ala Asn Leu Thr Leu Glu Asp Ala Ala
         195                 200                 205            
 Glu Cys Leu Lys Gln His
     210                



      <210> 1363
      <211> 545
      <212> PRT
      <213> Homo sapiens


      <400> 1363
 Asn Gly Trp Thr Ala Ser Asp Pro Val His Gly Tyr Trp Phe Arg Ala
   1               5                  10                  15    
 Gly Asp His Val Ser Arg Asn Ile Pro Val Ala Thr Asn Asn Pro Ala
              20                  25                  30        
 Arg Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp
          35                  40                  45            
 Pro Gln Asn Lys Asp Cys Thr Leu Ser Ile Arg Asp Thr Arg Glu Ser
      50                  55                  60                
 Asp Ala Gly Thr Tyr Val Phe Cys Val Glu Arg Gly Asn Met Lys Trp
  65                  70                  75                  80
 Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Ser Gln Asp
                  85                  90                  95    
 Leu Leu Ser Arg Tyr Arg Leu Glu Val Pro Glu Ser Val Thr Val Gln
             100                 105                 110        
 Glu Gly Leu Cys Val Ser Val Pro Cys Ser Val Leu Tyr Pro His Tyr
         115                 120                 125            
 Asn Trp Thr Ala Ser Ser Pro Val Tyr Gly Ser Trp Val Lys Glu Gly
     130                 135                 140                
 Ala Asp Ile Pro Trp Asp Ile Pro Val Ala Thr Asn Thr Pro Ser Gly
 145                 150                 155                 160
 Lys Val Gln Glu Asp Thr Gln Gly Arg Phe Leu Leu Leu Gly Asp Pro
                 165                 170                 175    
 Gln Thr Asn Asn Cys Ser Leu Ser Ile Arg Asp Ala Arg Lys Gly Asp
             180                 185                 190        
 Ser Gly Lys Tyr Tyr Phe Gln Val Glu Arg Gly Ser Arg Lys Trp Asn
         195                 200                 205            
 Tyr Ile Tyr Asp Lys Leu Ser Val His Val Thr Ala Leu Thr His Met
     210                 215                 220                
 Pro Thr Phe Ser Ile Pro Gly Thr Leu Glu Ser Gly His Pro Arg Asn
 225                 230                 235                 240
 Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Thr
                 245                 250                 255    
 Ile Thr Trp Met Gly Ala Ser Val Ser Ser Leu Asn Pro Asn Ile Thr
             260                 265                 270        
 Arg Ser Ser Met Leu Ser Leu Ile Pro Gln Pro Gln Asp His Gly Thr
         275                 280                 285            
 Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val Thr Met Thr
     290                 295                 300                
 Arg Ala Val Arg Leu Asn Ile Ser Tyr Pro Pro Gln Asn Leu Thr Met
 305                 310                 315                 320
 Thr Val Phe Gln Gly Asp Gly Thr Ala Ser Thr Thr Leu Arg Asn Gly
                 325                 330                 335    
 Ser Ala Leu Ser Val Leu Glu Gly Gln Ser Leu His Leu Val Cys Ala
             340                 345                 350        
 Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp Gly Ser Leu
         355                 360                 365            
 Thr Leu Ser Pro Ser Gln Ser Ser Asn Leu Gly Val Leu Glu Leu Pro
     370                 375                 380                
 Arg Val His Val Lys Asp Glu Gly Glu Phe Thr Cys Arg Ala Gln Asn
 385                 390                 395                 400
 Pro Leu Gly Ser Gln His Ile Ser Leu Ser Leu Ser Leu Gln Asn Glu
                 405                 410                 415    
 Tyr Thr Gly Lys Met Arg Pro Ile Ser Gly Val Thr Leu Gly Ala Phe
             420                 425                 430        
 Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys Ile Ile
         435                 440                 445            
 Phe Val Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Val
     450                 455                 460                
 Gly Val Gly Asp Thr Gly Met Glu Asp Ala Asn Ala Val Arg Gly Ser
 465                 470                 475                 480
 Ala Ser Gln Gly Pro Leu Ile Glu Ser Pro Ala Asp Asp Ser Pro Pro
                 485                 490                 495    
 His His Ala Pro Pro Ala Leu Ala Thr Pro Ser Pro Glu Glu Gly Glu
             500                 505                 510        
 Ile Gln Tyr Ala Ser Leu Ser Phe His Lys Ala Arg Pro Gln Tyr Pro
         515                 520                 525            
 Gln Glu Gln Glu Ala Ile Gly Tyr Glu Tyr Ser Glu Ile Asn Ile Pro
     530                 535                 540                
 Lys
 545



      <210> 1364
      <211> 311
      <212> PRT
      <213> Homo sapiens


      <400> 1364
 Met Gln Thr Phe Thr Met Val Leu Glu Glu Ile Trp Thr Ser Leu Phe
   1               5                  10                  15    
 Met Trp Phe Phe Tyr Ala Leu Ile Pro Cys Leu Leu Thr Asp Glu Val
              20                  25                  30        
 Ala Ile Leu Pro Ala Pro Gln Asn Leu Ser Val Leu Ser Thr Asn Met
          35                  40                  45            
 Lys His Leu Leu Met Trp Ser Pro Val Ile Ala Pro Gly Glu Thr Val
      50                  55                  60                
 Tyr Tyr Ser Val Glu Tyr Gln Gly Glu Tyr Glu Ser Leu Tyr Thr Ser
  65                  70                  75                  80
 His Ile Trp Ile Pro Ser Ser Trp Cys Ser Leu Thr Glu Gly Pro Glu
                  85                  90                  95    
 Cys Asp Val Thr Asp Asp Ile Thr Ala Thr Val Pro Tyr Asn Leu Arg
             100                 105                 110        
 Val Arg Ala Thr Leu Gly Ser Gln Thr Ser Ala Trp Ser Ile Leu Lys
         115                 120                 125            
 His Pro Phe Asn Arg Asn Ser Thr Ile Leu Thr Arg Pro Gly Met Glu
     130                 135                 140                
 Ile Thr Lys Asp Gly Phe His Leu Val Ile Glu Leu Glu Asp Leu Gly
 145                 150                 155                 160
 Pro Gln Phe Glu Phe Leu Val Ala Tyr Trp Arg Arg Glu Pro Gly Ala
                 165                 170                 175    
 Glu Glu His Val Lys Met Val Arg Ser Gly Gly Ile Pro Val His Leu
             180                 185                 190        
 Glu Thr Met Glu Pro Gly Ala Ala Tyr Cys Val Lys Ala Gln Thr Phe
         195                 200                 205            
 Val Lys Ala Ile Gly Arg Tyr Ser Ala Phe Ser Gln Thr Glu Cys Val
     210                 215                 220                
 Glu Val Gln Gly Glu Ala Ile Pro Leu Val Leu Ala Leu Phe Ala Phe
 225                 230                 235                 240
 Val Gly Phe Met Leu Ile Leu Val Val Val Pro Leu Phe Val Trp Lys
                 245                 250                 255    
 Met Gly Arg Leu Leu Gln Tyr Ser Cys Cys Pro Val Val Val Leu Pro
             260                 265                 270        
 Asp Thr Leu Lys Ile Thr Asn Ser Pro Gln Lys Leu Ile Ser Cys Arg
         275                 280                 285            
 Arg Glu Glu Val Asp Ala Cys Ala Thr Ala Val Met Ser Pro Glu Glu
     290                 295                 300                
 Leu Leu Arg Ala Trp Ile Ser
 305                 310    



      <210> 1365
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 1365
 Met Val Leu Ser Gly Ala Leu Cys Phe Arg Met Lys Asp Ser Ala Leu
   1               5                  10                  15    
 Lys Val Leu Tyr Leu His Asn Asn Gln Leu Leu Ala Gly Gly Leu His
              20                  25                  30        
 Ala Gly Lys Val Ile Lys Gly Glu Glu Ile Ser Val Val Pro Asn Arg
          35                  40                  45            
 Trp Leu Asp Ala Ser Leu Ser Pro Val Ile Leu Gly Val Gln Gly Gly
      50                  55                  60                
 Ser Gln Cys Leu Ser Cys Gly Val Gly Gln Glu Pro Thr Leu Thr Leu
  65                  70                  75                  80
 Glu Pro Val Asn Ile Met Glu Leu Tyr Leu Gly Ala Lys Glu Ser Lys
                  85                  90                  95    
 Ser Phe Thr Phe Tyr Arg Arg Asp Met Gly Leu Thr Ser Ser Phe Glu
             100                 105                 110        
 Ser Ala Ala Tyr Pro Gly Trp Phe Leu Cys Thr Val Pro Glu Ala Asp
         115                 120                 125            
 Gln Pro Val Arg Leu Thr Gln Leu Pro Glu Asn Gly Gly Trp Asn Ala
     130                 135                 140                
 Pro Ile Thr Asp Phe Tyr Phe Gln Gln Cys Asp
 145                 150                 155



      <210> 1366
      <211> 1454
      <212> PRT
      <213> Homo sapiens


      <400> 1366
 Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile
   1               5                  10                  15    
 Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn
              20                  25                  30        
 Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser
          35                  40                  45            
 Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys
      50                  55                  60                
 Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser
  65                  70                  75                  80
 Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile
                  85                  90                  95    
 Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys
             100                 105                 110        
 Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys
         115                 120                 125            
 Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met
     130                 135                 140                
 Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu
 145                 150                 155                 160
 Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro
                 165                 170                 175    
 Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met
             180                 185                 190        
 Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr
         195                 200                 205            
 Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val
     210                 215                 220                
 Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile
 225                 230                 235                 240
 Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val
                 245                 250                 255    
 Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg
             260                 265                 270        
 Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys
         275                 280                 285            
 Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile
     290                 295                 300                
 Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu
 305                 310                 315                 320
 Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser
                 325                 330                 335    
 Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His
             340                 345                 350        
 Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp
         355                 360                 365            
 Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn
     370                 375                 380                
 Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro
 385                 390                 395                 400
 Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu
                 405                 410                 415    
 Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro
             420                 425                 430        
 Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr
         435                 440                 445            
 Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys
     450                 455                 460                
 Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp
 465                 470                 475                 480
 Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys
                 485                 490                 495    
 Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys
             500                 505                 510        
 Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu
         515                 520                 525            
 Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly
     530                 535                 540                
 Val Val Ala Asp Lys Ile Gln Phe Ser Val Glu Met Cys Phe Asp Asn
 545                 550                 555                 560
 Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu
                 565                 570                 575    
 Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg
             580                 585                 590        
 Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser
         595                 600                 605            
 Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro
     610                 615                 620                
 Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp
 625                 630                 635                 640
 Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln
                 645                 650                 655    
 Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe
             660                 665                 670        
 Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile
         675                 680                 685            
 Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala
     690                 695                 700                
 Met Gly Ala Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro
 705                 710                 715                 720
 Leu His Gln Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr
                 725                 730                 735    
 Trp Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val
             740                 745                 750        
 His Val Thr Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe
         755                 760                 765            
 Cys Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu
     770                 775                 780                
 Thr Ala Phe Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val
 785                 790                 795                 800
 Val Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu
                 805                 810                 815    
 Lys Asp Cys Ile Arg Val Gln Thr Asp Leu Ala Lys Ser His Glu Tyr
             820                 825                 830        
 Gln Leu Glu Ser Trp Ala Asp Ser Gln Thr Ser Ser Cys Leu Cys Ala
         835                 840                 845            
 Asp Glu Ala Lys Thr His His Trp Asn Ile Thr Ala Val Lys Leu Gly
     850                 855                 860                
 His Ile Asn Phe Thr Ile Ser Thr Lys Ile Leu Asp Ser Asn Glu Pro
 865                 870                 875                 880
 Cys Gly Gly Gln Lys Gly Phe Val Pro Gln Lys Gly Arg Ser Asp Thr
                 885                 890                 895    
 Leu Ile Lys Pro Val Leu Val Lys Pro Glu Gly Val Leu Val Glu Lys
             900                 905                 910        
 Thr His Ser Ser Leu Leu Cys Pro Lys Gly Lys Val Ala Ser Glu Ser
         915                 920                 925            
 Val Ser Leu Glu Leu Pro Val Asp Ile Val Pro Asp Ser Thr Lys Ala
     930                 935                 940                
 Tyr Val Thr Val Leu Gly Asp Ile Met Gly Thr Ala Leu Gln Asn Leu
 945                 950                 955                 960
 Asp Gly Leu Val Gln Met Pro Ser Gly Cys Gly Glu Gln Asn Met Val
                 965                 970                 975    
 Leu Phe Ala Pro Ile Ile Tyr Val Leu Gln Tyr Leu Glu Lys Ala Gly
             980                 985                 990        
 Leu Leu Thr Glu Glu Ile Arg Ser Arg Ala Val Gly Phe Leu Glu Ile
         995                1000                1005            
 Gly Tyr Gln Lys Glu Leu Met Tyr Lys His Ser Asn Gly Ser Tyr Ser
    1010                1015                1020                
 Ala Phe Gly Glu Arg Asp Gly Asn Gly Asn Thr Trp Leu Thr Ala Phe
1025                1030                1035                1040
 Val Thr Lys Cys Phe Gly Gln Ala Gln Lys Phe Ile Phe Ile Asp Pro
                1045                1050                1055    
 Lys Asn Ile Gln Asp Ala Leu Lys Trp Met Ala Gly Asn Gln Leu Pro
            1060                1065                1070        
 Ser Gly Cys Tyr Ala Asn Val Gly Asn Leu Leu His Thr Ala Met Lys
        1075                1080                1085            
 Gly Gly Val Asp Asp Glu Val Ser Leu Thr Ala Tyr Val Thr Ala Ala
    1090                1095                1100                
 Leu Leu Glu Met Gly Lys Asp Val Asp Asp Pro Met Val Ser Gln Gly
1105                1110                1115                1120
 Leu Arg Cys Leu Lys Asn Ser Ala Thr Ser Thr Thr Asn Leu Tyr Thr
                1125                1130                1135    
 Gln Ala Leu Leu Ala Tyr Ile Phe Ser Leu Ala Gly Glu Met Asp Ile
            1140                1145                1150        
 Arg Asn Ile Leu Leu Lys Gln Leu Asp Gln Gln Ala Ile Ile Ser Gly
        1155                1160                1165            
 Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser Ser Asn Ala Ser
    1170                1175                1180                
 Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu Thr Ala Tyr Ala
1185                1190                1195                1200
 Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln Lys Glu Ile Ala
                1205                1210                1215    
 Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln Arg Asn Ala Tyr
            1220                1225                1230        
 Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu Gln Ala Leu
        1235                1240                1245            
 Ala Lys Tyr Ala Thr Thr Ala Tyr Val Pro Ser Glu Glu Ile Asn Leu
    1250                1255                1260                
 Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe Asn Ile Gln Ser
1265                1270                1275                1280
 Val Asn Arg Leu Val Phe Gln Gln Asp Thr Leu Pro Asn Val Pro Gly
                1285                1290                1295    
 Met Tyr Thr Leu Glu Ala Ser Gly Gln Gly Cys Val Tyr Val Gln Thr
            1300                1305                1310        
 Val Leu Arg Tyr Asn Ile Leu Pro Pro Thr Asn Met Lys Thr Phe Ser
        1315                1320                1325            
 Leu Ser Val Glu Ile Gly Lys Ala Arg Cys Glu Gln Pro Thr Ser Pro
    1330                1335                1340                
 Arg Ser Leu Thr Leu Thr Ile His Thr Ser Tyr Val Gly Ser Arg Ser
1345                1350                1355                1360
 Ser Ser Asn Met Ala Ile Val Glu Val Lys Met Leu Ser Gly Phe Ser
                1365                1370                1375    
 Pro Met Glu Gly Thr Asn Gln Leu Leu Leu Gln Gln Pro Leu Val Lys
            1380                1385                1390        
 Lys Val Glu Phe Gly Thr Asp Thr Leu Asn Ile Tyr Leu Asp Glu Leu
        1395                1400                1405            
 Ile Lys Asn Thr Gln Thr Tyr Thr Phe Thr Ile Ser Gln Ser Val Leu
    1410                1415                1420                
 Val Thr Asn Leu Lys Pro Ala Thr Ile Lys Val Tyr Asp Tyr Tyr Leu
1425                1430                1435                1440
 Pro Asp Glu Gln Ala Thr Ile Gln Tyr Ser Asp Pro Cys Glu
                1445                1450                



      <210> 1367
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 1367
 Met Tyr Glu Glu Met Leu Gln Thr Gln His Arg Asn Thr Ser Lys Lys
   1               5                  10                  15    
 Thr Gln Ile Ile Gly Ser Cys Tyr Ala Phe Ser His Ala Phe Ile Tyr
              20                  25                  30        
 Phe Ala Tyr Ala Ala Gly Phe Arg Phe Gly Ala Tyr Leu Ile Gln Ala
          35                  40                  45            
 Gly Arg Met Thr Pro Glu Gly Met Phe Ile Val Phe Thr Ala Ile Ala
      50                  55                  60                
 Tyr Gly Ala Met Ala Ile Gly Lys Thr Leu Val Leu Ala Pro Glu Tyr
  65                  70                  75                  80
 Ser Lys Ala Lys Ser Gly Arg Ala His Leu Phe Ala Leu Leu Glu Lys
                  85                  90                  95    
 Lys Pro Asn Ile Asp Ser Arg Ser Gln Glu Gly Lys Lys Pro Val Ser
             100                 105                 110        
 Thr Ser Val Ile Leu Asn Val Gln Ile Lys Met Ala Thr Val Gly Thr
         115                 120                 125            
 Gly Gly His
     130    



      <210> 1368
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 1368
 Met Asp Thr Ser His Thr Thr Lys Ser Cys Leu Leu Ile Leu Leu Val
   1               5                  10                  15    
 Ala Leu Leu Cys Ala Glu Arg Ala Gln Gly Leu Glu Cys Tyr Gln Cys
              20                  25                  30        
 Tyr Gly Val Pro Phe Glu Thr Ser Cys Pro Ser Ile Thr Cys Pro Tyr
          35                  40                  45            
 Pro Asp Gly Val Cys Val Thr Gln Glu Ala Ala Val Ile Val Asp Ser
      50                  55                  60                
 Gln Thr Arg Lys Val Lys Asn Asn Leu Cys Leu Pro Ile Cys Pro Pro
  65                  70                  75                  80
 Asn Ile Glu Ser Met Glu Ile Leu Gly Thr Lys Val Asn Val Lys Thr
                  85                  90                  95    
 Ser Cys Cys Gln Glu Asp Leu Cys Asn Val Ala Val Pro Asn Gly Gly
             100                 105                 110        
 Ser Thr Trp Thr Met Ala Gly Val Leu Leu Phe Ser Leu Ser Ser Val
         115                 120                 125            
 Leu Leu Gln Thr Leu Leu
     130                



      <210> 1369
      <211> 509
      <212> DNA
      <213> Homo sapiens


      <400> 1369
 acaaacaggt ggggtcaagc acggagagag aactgcccag ggtataaaaa gggcccacag     60
 gagaccggct ctaggatccc aaggcccaac tccccgaacc actcagggtc ctgtggacag    120
 ctcacctagt ggcaatggct ccaggctccc ggacgtccct gctcctggct tttgccctgc    180
 tctgcctgcc ctggcttcaa gaggctggtg ccgtccaaac cgttccgtta tccaggcttt    240
 ttgaccacgc tatgctccaa gcccatcgcg cgcaccagct ggccattgac acctaccagg    300
 agtttgaaga aacctatatc ccaaaggacc agaagtattc attcctgcat gactcccaga    360
 cctccttctg cttctcagac tctattccga caccctccaa catggaggaa acgcaacaga    420
 aatccaatct agagctgctc cgcatctccc tgctgctcat cgagtcgtgg ctggagcccg    480
 tgcggatcct catgagtata gtccccaac                                      509



      <210> 1370
      <211> 509
      <212> DNA
      <213> Homo sapiens


      <400> 1370
 acaaacaggt ggggtcaagc acggagagag aactgcccag ggtataaaaa gggcccacag     60
 gagaccggct ctaggatccc aaggcccaac tccccgaacc actcagggtc ctgtggacag    120
 ctcacctagt ggcaatggct ccaggctccc ggacgtccct gctcctggct tttgccctgc    180
 tctgcctgcc ctggcttcaa gaggctggtg ccgtccaaac cgttccgtta tccaggcttt    240
 ttgaccacgc tatgctccaa gcccatcgcg cgcaccagct ggccattgac acctaccagg    300
 agtttgaaga aacctatatc ccaaaggacc agaagtattc attcctgcat gactcccaga    360
 cctccttctg cttctcagac tctattccga caccctccaa catggaggaa acgcaacaga    420
 aatccaatct agagctgctc cgcatctccc tgctgctcat cgagtcgtgg ctggagcccg    480
 tgcggatcct catgagtata gtccccaac                                      509



      <210> 1371
      <211> 509
      <212> DNA
      <213> Homo sapiens


      <400> 1371
 acaaacaggt ggggtcaagc acggagagag aactgcccag ggtataaaaa gggcccacag     60
 gagaccggct ctaggatccc aaggcccaac tccccgaacc actcagggtc ctgtggacag    120
 ctcacctagt ggcaatggct ccaggctccc ggacgtccct gctcctggct tttgccctgc    180
 tctgcctgcc ctggcttcaa gaggctggtg ccgtccaaac cgttccgtta tccaggcttt    240
 ttgaccacgc tatgctccaa gcccatcgcg cgcaccagct ggccattgac acctaccagg    300
 agtttgaaga aacctatatc ccaaaggacc agaagtattc attcctgcat gactcccaga    360
 cctccttctg cttctcagac tctattccga caccctccaa catggaggaa acgcaacaga    420
 aatccaatct agagctgctc cgcatctccc tgctgctcat cgagtcgtgg ctggagcccg    480
 tgcggatcct catgagtata gtccccaac                                      509



      <210> 1372
      <211> 509
      <212> DNA
      <213> Homo sapiens


      <400> 1372
 acaaacaggt ggggtcaagc acggagagag aactgcccag ggtataaaaa gggcccacag     60
 gagaccggct ctaggatccc aaggcccaac tccccgaacc actcagggtc ctgtggacag    120
 ctcacctagt ggcaatggct ccaggctccc ggacgtccct gctcctggct tttgccctgc    180
 tctgcctgcc ctggcttcaa gaggctggtg ccgtccaaac cgttccgtta tccaggcttt    240
 ttgaccacgc tatgctccaa gcccatcgcg cgcaccagct ggccattgac acctaccagg    300
 agtttgaaga aacctatatc ccaaaggacc agaagtattc attcctgcat gactcccaga    360
 cctccttctg cttctcagac tctattccga caccctccaa catggaggaa acgcaacaga    420
 aatccaatct agagctgctc cgcatctccc tgctgctcat cgagtcgtgg ctggagcccg    480
 tgcggatcct catgagtata gtccccaac                                      509



      <210> 1373
      <211> 1796
      <212> DNA
      <213> Homo sapiens


      <400> 1373
 gtccagtgcg gtggaattcg agcaggcttc cctgattatg ggggcaggaa atggcctccc     60
 gggaggatca ctgatcctag tacagaaata cccccagagc agagaagctg tccgtgcctt    120
 atccaacaca ggtaactaag agttcttatg aacggtgact tcctgcagtg tttagataaa    180
 accaggctag aagtagagga ccaccaaatt cctcaagagc tgtttctctt catatgatat    240
 ttcgcatagc tcaaaatagg aggaggaacg aagtaacaga agttagggat aaagctcttt    300
 tattgtatgc attgaaacct tacaggggca gccttcgtgt cctgtggaat ctgctgtccc    360
 tcgggttttc ttctagggta ttggaatatt aaactgggat attaggggcc cctggggtcc    420
 agaatcttgc caatgaagag aagggcccct gtgtctgtgt ccctcagtac gaagatgaaa    480
 ggctggttaa ggtgatagtc cagcgggaag gtgaggtggg caggctgcag ccctgggctg    540
 ggggtggttc ccgccccatc ctcgttccac tcaaagccag cccggtgttc cacctgagtc    600
 agcttgatgg gtttgcctgt gatcttgcta aagtctggtg aatcaaacaa ggattgcagc    660
 ttcatctcct gcagggactt ggtgacttcg ccttcgtaac tcagcttcag cttggggaca    720
 gtgaggaccg cctgcacggt cttcagttct cggtctatgt catgaatgaa ctcggaggtg    780
 aggctctcct ctatcaaggt caaattctgg gtcactttca ggggcaggaa gaagatgata    840
 ctcatgcttc cggtcaaggg cagctgggca atcttgcagc tgagatctga atccaagcca    900
 tagcgtaaaa cagccttagg gtccgacatc atggggaccc tcacggtcct ctcttcatcc    960
 aagtagaaat cctcgaggga agtctttctg gagtcaaact ttgtttccca actgcccctt   1020
 gaagtgcgcc acacccgaga aggagaatgc tgatctcatc gggaatttcc tttgtggacc   1080
 tggcgagctt ccctttcatc tgcgcctgca cccagttgtt gatctcttgc aggtccaagc   1140
 gagggttgcc cgtcaggact ctgggcctgg tcccatatga cttttccaga ggtgccacaa   1200
 agctggattt tatgcgcagc ttcttctcaa agacgatccg ggaggcactc ttgaggttct   1260
 tctggggggc agtgaccgtg tcaaggagct ccttataggt accatggatg tctgggctgc   1320
 tgatcaagtc atagtagaga gcccggtgaa tgatggattc tgttcgctgc tccgctccca   1380
 gcgagagggc cgagagggcc gtggccacac tgagaggaga caggagcacg ttggtcgtgg   1440
 ggctcatgct ggatcgcacc cggtacaggt catagccgaa gttggagaca gccgctgcca   1500
 gcttgttcac ggggactttg aagaaaggat cctcctcctc caccagcgcc cctgtgctgt   1560
 cggggtctgg ggagccctcc tccggggggc tggcagggtt ctggcagctg ctgtgcccga   1620
 ggagggctcc aatgcagagg agtagcacca gggcctgcat cctggggcct gtggatacgc   1680
 tgcagctcca cacccagcct agtccctcta agcctgcaca ctgagggggc tccagccagc   1740
 acagagcttt ttttgctgcc ttctaatcca gcgtccagca ggcttcagat tacagc       1796



      <210> 1374
      <211> 1366
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1366)
      <223> n = a,t,c or g


      <400> 1374
 ctcaacccct gaaccactac ttcatctgct cttctcataa cacctaccta gtgggggacc     60
 agctttgtgg ccagagcagc gtcgagggat atatacggtg cagtggtggt agagaagggg    120
 tccaactcat gagagggacc atgtagaaaa gtgaggggag ctgtcagtgt ctaacagatt    180
 gggacagtgt tgtgggggtt taggggctga ggagccctgg ataccagaga cacttggagg    240
 agatattgaa gactggtggg agaatggtaa tgaaacccta tgggtcaatg gaacttctct    300
 ttcacaagct atgaaactct cctggaactc agaggccctg acagatttat atttaacaaa    360
 ttaataaaca gattgttaaa tggaaggcaa tagagaatag gagttaaaaa tataggttct    420
 ggagtcagac catctgaaat tatatcctag ctccttcact tggtactctg gggctaagta    480
 tttaacttct atacctcagt ctccccatct gtgaaacagg gatggtaaca gtgcctattc    540
 tgtctgggtt gttgtgaaga gataattcat atgtcaatag ctaataagca gttctgattt    600
 tattgtgact aatcatggat tagattgaat agtcaagata tctttctatt accagcaact    660
 gaactagtag cttcaaggga tacaaagatg agtggaacat atagtttcca ccttaagaag    720
 tctagctgag gaattaaagg gtaanattta ctgacaggtt gaataacccg gatgttgtat    780
 agggatataa agccagaaac acannnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    840
 nnnnnnncag cacggagaac gtttggaccc cgaatttgga acaagctggg caccattggg    900
 gagccgtttg cccaaaaggc cgaattcccc ggctggggta ggtggtttag taccacgctt    960
 cgggaggggg gggcgagatc ggttaacctg agaggaaggg tgaggtagca cgttgacaca   1020
 cggcctgtca tcggtggagg aatgtaagcg tgttagaagg aaagaggggc gcagtttgat   1080
 gaaacgtgct atggtcgggg tggggatgat attgtatggc gccagtaggt atcgagcggc   1140
 ggatatatgg gagtggggag gaagcgggta gtacgtaacg tagtgagaat gaaggagggg   1200
 agtagcattg gatgatggtg tgtagagtgg gaggtaggta tcgtcggatg gacggaagga   1260
 agggagtgta ggatggtgtg gtaggtatgg aagctacgag aggtgagttg gtaagcacgg   1320
 cacagtaggt gagggaggtt agctagtgag ggaatgtagg gagggc                  1366



      <210> 1375
      <211> 3156
      <212> DNA
      <213> Homo sapiens


      <400> 1375
 tttcgtggtg gcggcgtccg gagggtgctg gtttgttctc ggtgaacggc gcgcggggtc     60
 tctcctgagt gcgagctacg ggaccttcgc catgccgggg atggtactct tcggccggcg    120
 ctgggccatc gccagcgacg acttggtctt cccagggttc ttcgagctgg tcgtgcgagt    180
 gctgtggtgg attggcattc tgacgttgta tctcatgcac agaggaaagc tggactgtgc    240
 tggtggagcc ttgctcagca gttacttgat cgtcctcatg attctcctgg cagttgtcat    300
 atgtactgtg tcagccatca tgtgtgtcag catgagagga acgatttgta accctggacc    360
 gcggaagtct atgtctaagc tgctttacat ccgcctggcg ctgttttttc cagagatggt    420
 ctgggcctct ctgggggctg cctgggtggc agatggtgtt cagtgcgaca ggacagttgt    480
 aaacggcatc atcgcaaccg tcgtggtcag ttggatcatc atcgctgcca cagtggtttc    540
 cattatcatt gtctttgacc ctcttggggg gaaaatggct ccatattcct ctgccggccc    600
 cagccacctg gatagtcatg attcaagcca gttacttaat ggcctcaaga cagcagctac    660
 aagcgtgtgg gaaaccagaa tcaagctctt gtgctgttgc attgggaaag acgaccatac    720
 tcgggttgct ttttcgagta cggcagagct tttctcaacc tacttttcag acacagatct    780
 ggtgcccagc gacattgcgg cgggcctcgc cctgcttcat cagcaacagg acaatatcag    840
 gaacaaccaa gagcctgccc aggtggtctg ccatgcccca gggagctccc aggaagctga    900
 tctggatgca gaattaaaaa actgccatca ttacatgcag tttgcagcag cggcctatgg    960
 gtggcccctc tacatctaca gaaaccccct cacggggctg tgcaggattg gtggtgactg   1020
 ctgcagaagc aagaacccac agactatgac ttggtcggag gcgatcagct tcaactgtca   1080
 cttcggctcc catcctgcac acccacaggg ctgcagtaca gggacttcat ccacgtcagc   1140
 ttccatggac aaggtttacg gagctgccgt ttttagtggc tctggatcac aggaaagagt   1200
 ctgttgtggt cgctgtgagg gggaccatgt ctctgcagga tgtccttacg gacctgtcag   1260
 cggagagtga ggtgctagac gtggagtgtg aggtgcagga ccgcctggca cacaagggta   1320
 tttctcaagc tgccagatac gtttaccaac gactcatcaa cgacgggatt ttgagccaag   1380
 ccttcagcat tgctcctgag taccggctgg tcatagtggg ccacagcctc gggggagggg   1440
 cggccgccct gctggccacc atggtcagag ccgcctaccc gcaggtcagg tgctacgcct   1500
 tctccccacc ccgggggctg tggagcaaag ctctgcagga atattctcag agcttcatcg   1560
 tgtcactcgt cctggggaag gatgtgattc ccaggctcag tgtgaccaac ttggaagatc   1620
 tgaagagaag aatcttgcga gtggtcgcgc actgcaataa acccaagtac aagatcttgc   1680
 tgcacggttt gtggtacgaa ctgtttggag gaaaccccaa caacttgccc acggagctgg   1740
 acgggggcga ccaggaagtc ctgacacagc ctcttctggg ggagcagagc ctactgacgc   1800
 gctggtcccc ggcctacagc ttctccagcg actccccact ggactcttct cccaagtacc   1860
 cccctctcta ccctcccggc aggatcatcc acctgcagga ggagggcgcc tcggggcggt   1920
 ttggctgctg ctctgctgct cactatagcg ccaagtggtc acacgaagcg gaattcagca   1980
 aaatactcat aggtccgaag atgctcaccg accacatgcc agacatcctg atgcgggcct   2040
 tggacagcgt ggtctccgac agagcggcct gcgtctcctg tccagcacaa ggggtctcca   2100
 gtgtggacgt ggcctgacca gggccactgg aaactgtccc aggaacgatg gactcacgct   2160
 tttgtcctta aactgactta ccatccgagg agttcccatg acgccaaaac agcgaatgtc   2220
 catcaacagg aatcggatgg gaacagaatt ccatggtctc aatgacttaa gtttatggga   2280
 agtcattgtg gccataatgg tagcagaagt agcgagcacg ctcaggtgat aggacgactc   2340
 ctgagaccca gcgaccgtgg agacagcctc gggaagccct ggcccgtgga tggatccctt   2400
 ggctgtctga ggactgctcc agaagtgcgg gaatccaggg cccacccaga agaccgtgaa   2460
 cagttcctta gcctcccacc cccaaggcag ctcttttcat ccaactcagt ttacaggcgt   2520
 ggtttgtttt tcaaactggg cttcctggat gtacaaatgg aactgtggtg agggtgcggg   2580
 ctggggtttt ctcctgggcg tcaccaaggg cagccctggg ctctggctgg ggatgaagac   2640
 gaaacccgat cgggaaagta agtggagccc ccggccccgc cgagccacag ccccccaact   2700
 gcctattccc actgcccagt tgtttgtcca catcaggagt tgctgattga attcttgcta   2760
 ctcttctggc tctggggtcg gccagtggat tcaggagttg aaacaataaa gcgcgcgtca   2820
 cgatagtgct tgtgtgtaca gctgcgtgct ctcttattgg ggatttccag gtagcgctac   2880
 tatactgggt ggttgtagag caatgatgtt tccacgtttt ttttaaaccc tggggttctg   2940
 gctacagatg gaagattgcc caagcactga tttcaccccc tctcccaccg gaagcccaac   3000
 agaatgacag gagggagatt tctccaaaaa agcagagacc cacaggatgg gaaaagacac   3060
 tccaacaaca gtcagaggac gcacagtaca gaaccttaag ggggaaggaa agacatgaac   3120
 tgaccccagc ttacaagacc ctgggcagct gtgaag                             3156



      <210> 1376
      <211> 723
      <212> DNA
      <213> Homo sapiens


      <400> 1376
 gaccgtctct ggccagtttg cttcaaccca ttccattccc caaagaagct ctcgcacatg     60
 agaagttcac caaggaactg aagtacgtga ttcagaggtt cgccgaagac cccaggcaag    120
 aggtccactc atgcctgctg agcgtgcggg ccggcaaaga tggctggttc cagctctaca    180
 gccccggagg ggtggcctgc gacgatgacg gggagctgtt cgccagcatg gtgcacatcc    240
 tcatgggctc ctgttacaag accaaaaaat tcctgctctc cctggcagaa aacaagctgg    300
 gtccctgcat gctcctggca ctgaggggga accagaccat ggtggagatc ctgtgcttga    360
 tgctggaata caacatcatc gacaacaacg acacccaact gcagatcatc tcaaccctgg    420
 agagcacaga cgtggggaag cgcatgtacg agcagctgtg tgaccggcag cgggagctga    480
 aggagctgca aaggaaaggc gggcccacca ggctaacact gccctccaag tccacagacg    540
 ctgacttggc tcgtttgctg agctccggct ccttcggaaa cctgggagaa cctcagtttg    600
 gccttcacca atgtaaccag tgcctgcgcc gagcacctca tcaaactgcc ttcgctcaag    660
 cagctgaacc tgtggtccac tcagttttgg agacggtggg cctttcggtt cctgttcggg    720
 aac                                                                  723



      <210> 1377
      <211> 440
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(440)
      <223> n = a,t,c or g


      <400> 1377
 cccctgggag gtgggactcc ggactggcgg ttttggaatg tggggcagat ggtcccaaca     60
 ggcccgaggc ccctggtgtc aggcatcagc agcttcctcc tcagagtcca ggtctggcgg    120
 tgccttcgtg cccacggtct ttactccctg cgccgggacc aacaatgccc tgggtcctga    180
 gggctgcttt tgacctgtgc ggggagcagc cccaacttgg gggggggtct tacaggcttg    240
 tggacctgcc ttttcctgac aattcaggtc agagtctcaa gacccctggg aggggcccca    300
 aacaactgtg aggcctgggt gctctgagcc cactgaccgc tagccttgtg cttggcccca    360
 gcggcaagcc tgcacgagct gtgtgctgcc aaagtgtcag aggtccttca taacagagtg    420
 cacaggacgg aggaagtgan                                                440



      <210> 1378
      <211> 1507
      <212> DNA
      <213> Homo sapiens


      <400> 1378
 ggaggcagga ggtaggaatg gaaatttcag aaaaccagaa gaaacttgcc atgttaaatg     60
 ctcaaaaggc aggacatgga aagtcaaaag gctacaacag gtgccctgtg gccccaccgc    120
 accagggcct gcaccccatc caccagcgcc acatcactat gcccacaagc gtcccccagc    180
 agcaggtctt tggcctggcg gaacccaaga ggaagtcctc gctcttctgg cacaccttca    240
 acaggctcac ccccttccgg aaatgaaaac aggaggctgt gcttccatgg agctgggtgt    300
 caagagaaga actgtctttg tttcttgggt gcttcaatcc agggaaagtt tcttggaccc    360
 agtgataaaa acttcctttt agggatcaat gaaggagaga aggtcttgga atcaccttca    420
 gtctttggag acccagctgc ctttgtggaa gggaggagac ggtcatgaca caaagcttta    480
 tcctacacag aaacacccgt gacccactat gagatggccc agatgtggga cccggtacca    540
 tgctctaaag cgagtgatta ggcagcagct gaagccaccc ctgctgatga tgagcaagtg    600
 cctgctgcag gtccaaacac agcatccagg gctttgcagt tcctaaggag tgatgaggtt    660
 agaggatcac ttctgcattt gattttcaag gatgccgtca agacggggtt gacacaatgc    720
 tgcacgtgtc tggtcacact tagaaattga gctcttactc tcttctgtaa tactggggga    780
 cctacagctg ccgtggggct gaccacggtg ttccctggca tcgtctgtgt ccacacagat    840
 gctaactggt agtgcaaatg tcatcctgca aggttcctct tcctgcaagc aaagtggaga    900
 gaaagaagat gcatctgtca ccttcatcag ggtcctcagt gcagagcaac ttacgcatcc    960
 tcaagaatcc actgcttttc aggcaaggag ggagaaatcc tgctgcacac tggctttgtc   1020
 ccggagtcgg attccctcct gcctgcacgc cttcagtaac tccgagcaga aatcacatct   1080
 tgcccacatg ctgtaaccta agaaactgct atgcaaggct gggtgctgtg gctcatgcct   1140
 gtaatcccag cactttggga ggccaaggca ggtggatcac ctgaggtcag gagttcgaga   1200
 caagcgtggc caatatggca aagcccagtc tctactaata atacaaaaat tagctgggca   1260
 tggtggcgca tgcctgtaat cccagctact gggaaggctg aggtaggaga atcttttgaa   1320
 tctgggaagc ggaggttgca gtgagctgag atcgcaccac tgcactccag cctgggagat   1380
 acagcgagac tgtctccaaa aacaaaaaca aaaacaaaaa acattcagac aactgtttgc   1440
 attataaaaa gctcatttac tgtaatattt atgatacaag gaatatgaaa atgcactggt   1500
 cagaagg                                                             1507



      <210> 1379
      <211> 3104
      <212> DNA
      <213> Homo sapiens


      <400> 1379
 cgacgatttc gtgggagttc tgagtgcgac ggcgcaggtc tgcaccatgg cggcccggct     60
 tgtcagccga tgcggggctg tgcgtgcagc tccccacagc ggcccgctgg tgtcctggcg    120
 caggtggtcc ggcgcctcaa cagacaccgt gtatgacgtg gtggtgtcgg gtggaggcct    180
 ggtgggcgct gccatggcct gtgccttggg atatgatatt cactttcatg acaagaaaat    240
 cctgttgctc gaagcaggtc caaagaaagt actggagaaa ttgtcagaaa cttacagcaa    300
 cagggtcagc tccatttccc ctggctctgc aacgcttctc agtagttttg gtgcctggga    360
 ccatatctgc aacatgagat acagagcctt tcggcgaatg caggtgtggg acgcctgctc    420
 agaggccctg ataatgtttg ataaggataa tttagatgac atgggctata tccttggaga    480
 atgatgttca tcatgcatgc tttcactaag cagttggagg ctgtgtctga ccgagtgacg    540
 gttctctaca ggagcaaagc cattcgctat acctggcctt gtccatttcc tatggccgac    600
 tccagccctt gggttcatat taccctaggt gatggcagca ccttccagac caaattgttg    660
 ataggtgcag atggtcacaa ctccggagta cggcaggctg ttggaatcca gaatgtgagc    720
 tggaactatg accagtctgc tgttgtggct actctgcatt tatcagaggc cacagaaaac    780
 aacgtagcct ggcagagatt tcttccctct gggcctattg ctctgctccc gctctcagac    840
 accttgagtt ccttggtttg gtccacgtcc catgaacatg cagcagagct agttagcatg    900
 gatgaggaaa aatttgtgga tgccgttaac tctgcctttt ggagtgatgc tgaccacacg    960
 gacttcatcg acacagctgg tgccatgctg cagtatgctg tcagccttct gaagcccact   1020
 aaggtctcgg ctcgccagct gcccccaagc gtagccaggg tggatgccaa aagccgagtt   1080
 ctgtttcctc ttgggttggg acatgctgct gagtacgtca ggcctcgggt ggcgctcatt   1140
 ggggatgcag cccacagagt ccatccgctt gcaggacagg gtgtcaacat gggctttggg   1200
 gatatctcca gcttggccca tcacctcagt acggcagcct tcaatgggaa ggacttaggt   1260
 tccatgagcc acctcacagg ttatgaaaca gaaagacagc gtcacaacac tgctcttctg   1320
 gctgctacag acttactaaa aaggctctat tctaccagtg cctccccgct tgtgttgctc   1380
 aggacgtggg gcttgcaggc cacaaatgca gtgtctccac tcaaagaaca gattatggcc   1440
 tttgcaagca aatgagtact cctctcctaa agaaagatta cgttgatgaa aaagaacatc   1500
 ctgcccagga cccatcatac atattttcaa gatcttattt aatttaataa acttacttta   1560
 cattaaaatt ctctttttct tctttgctta atgggcctgt ggcacccaaa taatgaatga   1620
 taatttgctg tgaggagcgt atattagcca gaccaaagga aaaaacttcg aaggaagact   1680
 tacaatttgg ttgaaaagag ctttttatta ctaaaaaacc cacaaggtgc tgtctcactc   1740
 atttccagtt aatcatttct aaagagaaaa tttacatttt gtttttgttt taatgttggt   1800
 cataaattta tacagttgtt ttttcgatag aggtaagaat tagactcgat gcatttttgt   1860
 tagaattgct gtttaaatgt taacatcagg aatgcaaatt aaatataaat tgctttaacc   1920
 tttgttacag gggatactgg gacttttctg aaaggaaaac cagggtctca ttaatgctag   1980
 gttattactt tatcacaggc accagatttt ccattttatt tatgggttcc tctctgggac   2040
 accactggtc cggtttaata aaacaataaa taattcattg cacagatccg aagtacctca   2100
 ggaaccagat cacaagggaa accgattagc agcagaattt gttcatgttt ggtggcagac   2160
 tggtggccaa ctggagggag gggagtttta ctgtgggttt ttgaagaggt ctcgtcacaa   2220
 gaccagagat gcctcttgaa gagattttta ggttgtaggt ttgcttactc taaagaacat   2280
 cttgcccaga agtctgattt gagatgaaat gaagagaaac agtctgcttt tgaaccaagt   2340
 aaggtattct tgggaataat ttttagagcc atgagaaatc tattcttaca ggggtgcttt   2400
 tcaggcaaat gcagaaaatt taaaagagtc tagaacaaaa aagtgacaat gtcacaacct   2460
 tgctggaatc tcaggaaaaa gaattaaaga tggcagctgc tgtgaaaagc tgtgtgactc   2520
 ctggcggaga ctgcagggac aaggtcatct ttcacaaaaa atggaaaggt ggcctagatg   2580
 aggaggacac agactctcca gaagttatgc aaacaaaatc aggcaagatg aagaatttta   2640
 aggcacacct ccattggccc acagagagtg ttcttcatat gacaatgatg ttaaacacca   2700
 tctgtcacgt accaggccat gtcctaagta ttttaaatat gttaacacat ctacaaagag   2760
 gaaactatta gaatctgtag gacctcttaa gcccaaaggg tctactgcag gcaggatggg   2820
 cgttacagaa aaaaataaaa actctcattc caaattgctc ctaagatgga caaattggtt   2880
 acttctccag aaggtctaat caaggttaac aaaataggta agttcgtgga gttagaatgc   2940
 atcttccctg gagttcagag gtatttggga tgaccaaagg agtctgctgg acagtatgtg   3000
 tgttttacaa aatggccccc acagtgatta aagaccagag acttatatct ctgcatttgt   3060
 caagctggaa cagtctttag tgaacacagc gaattccacc gcac                    3104



      <210> 1380
      <211> 3828
      <212> DNA
      <213> Homo sapiens


      <400> 1380
 acatccacgg gaacctgggg aaggcctgca tccccgacac catccccaac cgcgtgacag     60
 accacacctg tcccagcgga ggccccctct cacccagcct caccaccccg ctgcccccgc    120
 tagacatctc tgtggctgag cagcagcagc tgagctacat gccgctgcgg gatgattacg    180
 agatcgagta tgaccaggat gccgagacgc tcatcagcgg gctctctgtc aactatgatg    240
 acgacgacgt ggagatcgag ctgaagcgcg cccacgtgga catgtacgtg cggaagctga    300
 aagagagaca gcggcggaag aacatcgccc gtgactacaa tctggtgcca gccttcctgg    360
 ggaaggacaa gaaggagaag gaaaaggcgc tgaagcgcaa gatcaccaag gaggagaagg    420
 agctgcgcct gaagctgagg ccgctgtacc agttcatgtc atgcaaggag tttgatgacc    480
 tttttgaaaa catgcacaaa gaaaaaatgc tccgggccaa gatccgagaa ctgcagcggt    540
 accggcgaaa cgggatcacc aagatggaag agtcggcaga gtacgaggca gcgcggcata    600
 aacgggagaa gaggatggag aacaaaaacc tagccggctc caaacgggga aaggaggacg    660
 gcaaagacag cgagttcgcc gccattgaga accttccagg cttcgagctc ctgtcagatc    720
 gcgagaaggt gctctgcagc tctttaaact tgagtccagc ccgctacgtg actgtgaaga    780
 ctattataat taaagaccac ctccagaagc ggcaaggaat cccctccaaa agccgccttc    840
 ctagctacct ggacaaagtc ctaaagaaaa ggattttgaa tttcctcaca gaaagcggct    900
 ggatctccag ggacgcgtct tgaagctgag acgctttgaa agccagggtg atgctcagac    960
 agtgtgccag ccaaaatgac ttgggggagg ggagccgctt ccccactgtt gctctttttt   1020
 aaacaaattg agttcctttt tttaagatag aaattctttt catggtcctc tgaaagaagc   1080
 aatagtaaca atcttatatt ggatcatggg ggaagcaaat gtgtgtattt taagtgagtt   1140
 cctgcgagtc atacactgcg atgatgctcc gcctttaccc gttcagttgg gagcttattg   1200
 tgagattgga tcatttcctt ttgagtgttc ttctctttgg tacaaaacct attgtgggtg   1260
 acaggagcag tgttttcctg ctggacccgc aagccaccag ctatttcctg gtgacacaag   1320
 ctcttctcag gcggggctgc ctgcaggctc ccgttttctg agcccacgct gcccacagct   1380
 gaccccagcg cagccccggg cacgcggcac tttacatggg ggcagcttgg gcccagactc   1440
 ctccgctgtg tagcagatga ggaaaatcag gccagaggac aacaggctgg cgttttgttg   1500
 ggaactgaag aggaatctgt tgaacacagc gaccagatga ccttccattt caccggcggc   1560
 agcagtttca gcgtgcagtt cccaaacccc aaagctgacc ctgcgcccca tttgaatacg   1620
 gccagagcct gctggttcac tttgggtaga gccgtgcctc ttgggcaggc tcccatagtg   1680
 accacgtccc cacgaatggg aaagcacgtt agtgggaggg acgtaggaca cgtgtggacc   1740
 gccaggccct ctcagtccat tttccggggc tgctcggtgc tgctgttaag acgtgagtgc   1800
 atttcacttg gaagaaccca ttgtacaaag ttcaaggcta agagttctga attctggcgt   1860
 cagcttcctc aggattttct tcagttgcaa gtacctttcc actgaaaata tgagcatgcc   1920
 cgcctggcta gtaggcatct gtaagagtgt cgccaggccc gcgccagctg aggcctcaga   1980
 ctagccaggc aagagccgtc tgaccagttg gctggcggtg gttctggtgg agcacgaggg   2040
 agcccgggtg gtgccctgag cctcgagctg ctctctgtca ctgtcttgaa tcagactcag   2100
 aaatggcttc ttcccagccc tgcctacaag tttttctctg gggtcctctt tcaaggatgt   2160
 ccacggtacc ttcctcctga aacttgagga agtcttttgt cttccagctg ctcagggttc   2220
 tctggtccaa gaccctgctt taaagagagt ctttggcgtg ctcagactcc agcgctccgt   2280
 tcttcaagga ggttgacttg cctctcgggc cccgtaggta ccaagagact gtttacctcc   2340
 cagaatgttt gggcttgaag ttacattaaa gtgaagttat ttgaaagaaa gaaaacctca   2400
 tcatttctaa ggatgactta attactgtgc cttttccttt ctttttacac atcctactgt   2460
 cccttagggt aaaattttca gcattaaata aaacatttca aatatattgt atatggcttt   2520
 agttgtaaac tatactgcat gctgacagag aagcgctctt ttagctaagc ccagaacttc   2580
 tcttttgaca ataaagtact gagcagtggt atcatgaggg ccacctccac attgtcccct   2640
 gcagaataaa tgcggatgac agaaagctta tgctgtctac cactgaacag tgatggagat   2700
 ggtgctaagt ttttacagtt gtcttaaccc cagtggttct caaggtgggg ctcctggccc   2760
 agcagcagca acttgtttgt tagaatgcag acgcgcaggc cccacctggc ctcctgaatc   2820
 aaaatggtgt gcggcagggt gcagcgagct gttttcacga ggcctccagg tgactggatg   2880
 taagcttgct tgagaactat gggttttagc tattctggtg tctccctgat tttctacagc   2940
 cgcaggatcc tagtttggtg aggttttaaa tttaatctta tttttatata aaatgattgc   3000
 cagacggtac tatattaagc ttgaagaagc agaagatccc tgttaatgtg tatggcccag   3060
 gccaagagct gtcaaatgaa aaactttgtg ctgaagcagg tttttagtat gtatatcttt   3120
 ttgatggtat gaagaattta tttaggcttg actgttttaa aacaccataa tgaatgtata   3180
 attaatttat gttaaagtat taaccctttg tcacaaagga atggtaatgt gattggctgc   3240
 ctgttagccc atcgactatt cccgtcacgg tagtccttac ctctgtcggc agctcagagc   3300
 ctccacattt ttatatttaa ttctcatgat aaattagcca ccataatccc atggaattag   3360
 gtcttgttaa aatctagtcc gggcgcagtg gctcacgcct gtaatcccag cactttggga   3420
 ggccaaggcg ggctgatcac gaggtcaaga gatcgagacc atcctggcca gcatggggaa   3480
 accctgtctc tgctgaaaat acaaaaatta gctgggtgtg ggggtgcatg cctgtagtcc   3540
 cagctacttg ggaggctgag gtaggagagt tgcttgaacc tgggaggcgg aggttgcggt   3600
 gagctgagat cacgccacta cactccagcc tggtgacaga gcaagactcc atctcaaaaa   3660
 aaaaaaatct aagcaaacta tctttgagtc aaaaaaagtt ggataactca tctatatttg   3720
 aaataatgct gtctgaatgg ccaacatccc aagaatgtat taaaaacagc aacctgccta   3780
 ccgttttgat gacctttttc catattaaac aagttgagaa caaaaaaa                3828



      <210> 1381
      <211> 1338
      <212> DNA
      <213> Homo sapiens


      <400> 1381
 atttttagta gagacggggt ttcaccgtgt tagccaggat ggtctcgatc tcctgacctc     60
 gtgatccgcc ctcctcggcc tcccgagtag ctgggactac aggcgcccgc caccacgccc    120
 ggctaatttt ttgtattttt agtagagacg gggtttcacc gtgttggcca ggatggtctc    180
 gatctgctga cctcgtgatc cgccggcctc ggcctcccgc agtgctggga tttcaggcgt    240
 gagccgcggc cggccgccct cctaggtttt agtaggttgg agagctgtgg gtctcgcacg    300
 cttcaccagc caaattccta agtccctttt tatcgtttta accctaagag tcacaggtcg    360
 tgttacagat cagggggaca gacaagcaca gaacccccat ctcccagcac ccagcctccg    420
 agtcagatgc cccccgccct ggtctctcac agctgtgctc actaggcaag cctggccggc    480
 ccctccctgg tagcagtgaa gctgttgatt atgtttgtcg ttgttgcatt tcagttacac    540
 aagtgttacc agaatgcagt ctcctttata caaacttaaa agtatgagtt taagcctagt    600
 ctcttgtgcc ctccaccccc gccattccca gaggggactg ctctctcctg gtggacacat    660
 tctacaattt caccaacata gacgccgaca cgcgggcacc tacgtaaaca cacatgcgat    720
 gctcatgtaa acaaacatcc atgcacacac tgccacccag gtacacacac ccgagaatgt    780
 gtgtgtccct gtacgtgaac ccgagtgtgc ccacgtacac gtacccaact gtcctcatgt    840
 acacgtaccc gagtgtgctc acgtatacgt acccgagtgt gctcacgtac acgtacccga    900
 gtgtgcccat gttcatgtat ccgtgtgtgt acgtacccga gtgtgtgtat gtgcctgtgt    960
 gtacgtactt gagtttgtgc ccatgtacgt gtacccgagt gtgtgtacgt gcctgagtgt   1020
 gtgtacgtgc ccaagcacag gcacattgtc cagatccaca taacactcct tctttgcagt   1080
 tgcttcctcc acacacagag tgtcccccat ctctccaggg tacacactgc agtgtgggtg   1140
 aacatcaaaa gccgtgcagt gagagaagcc aatcacagca ggtccgtgcc gcctgacagt   1200
 gttcacatgg aagttcggaa aagacggctc tgtagagaca gacagatttg tggtttccca   1260
 aggttggggg tgacggttag gagtcaggat ttctttttgg ggggatgata atgttctgta   1320
 atggatcgcg gtgacagg                                                 1338



      <210> 1382
      <211> 912
      <212> DNA
      <213> Homo sapiens


      <400> 1382
 tttttttttt ttcaacttca gcattcaatt ttattatagt accatctccc tcaacaaaca     60
 agatcagcag ccagtgtggg atggtgctca atggggctcc acttcccact agagtgtaag    120
 ctgcttccac gcatgctact gcgtgctccg agccatcgca gcggagtctc ttctcaccca    180
 gctttgatgg tggggcgact cccgtgtctg cagctgtggt ccaaagggtg tctgtgctgg    240
 atacagaagt tgccgtgaca ttgggcacat accatctgca gcatctcttt cttcttgcag    300
 ccctcttttg agcaacggta tgtaaaaatc ttctctttct tcttcccagg gtgagagtca    360
 cagtctctgt caatgtgatc accaaccacc acgtctggta tctggccctt ttttactggg    420
 atgggggtat tacagagtgg gcatactggg acgtgaacat ccttctggaa tgcaaacgga    480
 cacttatgtg cagcgtatgg aaaatgatct ttacagaaat cttgtttaca tgcatcacat    540
 tttactggaa gaaaatctag ctgcttgcaa gtcttttctg aacaatgctt ccccaaatca    600
 ggaaactcca ttatgagaac agtgctcaaa acgcagatgg cggagttaag tgtcacctgg    660
 ctctcgtcgg ggacccaggc agctgaggtg agcagcagat ggaagagacg taaactcagg    720
 tgtcctcctc cgtagtcggc tccgggtagc taagcagaaa gaacctcgac actggcaccg    780
 agacgccgtc ggaggcacac ccacacccac accggaacgc aacatctcgc tgcccgcggc    840
 ctacggggat ttatccgcag cccccggatc tgagagccgt ctgggccttg ggggaattcc    900
 accgcactga ac                                                        912



      <210> 1383
      <211> 364
      <212> DNA
      <213> Homo sapiens


      <400> 1383
 agcaggctca gaatctgccc ccattgcctc acccatccca caggacagcc taagagaggg     60
 gtctactcct cctccccttc cctctgtccc cttcctcccc acccctgccc ctcacctatc    120
 cataggcctc cacagcaggc ttccagagat gcttgaggcc aagcccctcg cagtcataaa    180
 ttatggtgat ggtctccacc ttcctcccca actgcaggga acagagagca ggaagtcttg    240
 tcaggctgtc ctacttcaga agcccgttcc agtccaggcc aaatgattgc actgtgcatc    300
 cagagagcaa tcagagctag ttagggccgg acctagagtt ttccaaactg agataatcac    360
 ccca                                                                 364



      <210> 1384
      <211> 1366
      <212> DNA
      <213> Homo sapiens


      <400> 1384
 tggggcagag gttgggaaga tggcgtggcg aggctgggcg cagagaggct ggggctgcgg     60
 ccaggcgtgg ggtgcgtcgg tgggcggccg cagctgcgag gagctcactg cggtcctaac    120
 cccgccgcag ctcctcggac gcaggtttaa cttctttatt caacaaaaat gcggattcag    180
 aaaagcaccc aggaaggttg aacctcgaag atcagaccca gggacaagtg gtgaagcata    240
 caagagaagt gctttgattc ctcctgtgga agaaacagtc ttttatcctt ctccctatcc    300
 tataaggagt ctcataaaac ctttattttt tactgttggg tttacaggct gtgcatttgg    360
 atcagctgct atttggcaat atgaatcact gaaatccagg gtccagagtt attttgatgg    420
 tataaaagct gattggttgg atagcataag accacaaaaa gaaggagact tcagaaagga    480
 gattaacaag tggtggaata acctaagtga tggccagcgg actgtgacag gtattatagc    540
 tgcaaatgtc cttgtattct gtttatggag agtaccttct ctgcagcgga caatgatcag    600
 atatttcaca tcgaatccag cctcaaaggt cctttgttct ccaatgttgc tgtcaacatt    660
 cagtcacttc tccttatttc acatggcagc aaatatgtat gttttgtgga gcttctcttc    720
 cagcatagtg aacattctgg gtcaagagca gttcatggca gtgtacctat ctgcaggtgt    780
 tatttccaat tttgtcagtt acctgggtaa agttgccaca ggaagatatg gaccatcact    840
 tggtgcatct ggtgccatca tgacagtcct cgcagctgtc tgcactaaga tcccagaagg    900
 gaggcttgcc attattttcc ttccgatgtt cacgttcaca gcagggaatg ccctgaaagc    960
 cattatcgcc atggatacag caggaatgat cctgggatgg aaattttttg atcatgcggc   1020
 acatcttggg ggagctcttt ttggaatatg gtatgttact tacggtcatg aactgatttg   1080
 gaagaacagg gagccgctag tgaaaatctg gcatgaaata aggactaatg gccccaaaaa   1140
 aggaggtggc tctaagtaaa actgggattg gacagtagtg gtgcatctgg tccttgccgc   1200
 ctgagagccc caggagacat cggctagagt gaccatggct atgctcccgt ctggaagatg   1260
 ccagcatctg gcctcccact gttttcagct gtgtccccca gtccgtgtct ttttagaatg   1320
 tgaatgatga taaagttgtg aaataaaagg tttctatcta gtttgt                  1366



      <210> 1385
      <211> 392
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(392)
      <223> n = a,t,c or g


      <400> 1385
 tttcgtcggg ggcccaagct cccagctccc aaatttccct gcttctatgc cctttgagct     60
 cagtccagat gggagctggc tccttcagaa agggggctca gaacagggtg tggggagcta    120
 cctctctctg cctcccccca ccacatctgt ctgcagggct gggagccccc acgattcagt    180
 ggtcctgagc cttctgaagt taggcttctg cctggtggtg gggatcctga catcaaggat    240
 gggacaccct ggatggaggt tcctggggcc tggcccccaa gactatgaag agcctttgct    300
 gaggccatga ggggttacca tggcgaccga ggcagccatc cccgcccagc ccgctttgct    360
 gaccaacagc atatggacgt gggccctgct gn                                  392



      <210> 1386
      <211> 1802
      <212> DNA
      <213> Homo sapiens


      <400> 1386
 cccacgcgtc cgcccacgcg tccgctgggg ctgagagttc acctgtctca ggaaccacct     60
 gagcccacag atcctgtggg cagcggccag ggcagccatg gcttgggcaa gtaggctggg    120
 cctgctgctg gcactgctgc tgcccgtggt cggtgcctcc acgccaggca ccgtggtccg    180
 actcaacaag gcagcattga gctacgtgtc tgaaattggg aaagcccctc tccagcgggc    240
 cctgcaggtc actgtccctc atttcctgga ctggagtgga gaggcgcttc agcccaccag    300
 gatccggatt ctgaatgtcc atgtgccccg cctccacctg aaattcattg ctggtttcgg    360
 agtgcgcctg ctggcagcag ctaattttac tttcaaggtc tttcgcgccc cagagcccct    420
 ggagctgacg ctgcctgtgg aactgctggc tgacacccgc gtgacccaga gctccatcag    480
 gacccctgtg gtcagcatct ctgcctgctc tttattctcg ggccacgcca acgagtttga    540
 tggcagtaac agcacctccc acgcgctgct ggtcctggtg cagaagcaca ttaaagctgt    600
 cttgagtaac aagctgtgcc tgagcatctc caacctggtg cagggtgtca atgtccacct    660
 gggcacctta attggcctca accccgtggg tcctgagtcc cagatccgct attccatggt    720
 cagtgtgccc actgtcacca gtgactacat ttccctggaa gtcaatgctg ttctcttcct    780
 gctgggcaag cccatcatcc tgcccacgga tgccacccct tttgtgttgc caaggcatgt    840
 gggtaccgag ggctccatgg ccaccgtggg cctctcccag cagctgtttg actctgcgct    900
 cctgctgctg cagaaggccg gtgccctcaa cctggacatc acagggcagc tgaggtcgga    960
 tgacaacctg ctgaacacct ctgctctggg ccggctcatc ccggaggtgg cccgccagtt   1020
 tcccgagccc atgcctgtgg tgctcaaggt gcggctgggt gccacacctg tggccatgct   1080
 ccacacaaac aacgccaccc tgcggctgca gcccttcgtg gaggtcctgg ccacagcctc   1140
 caactcggct ttccagtccc tcttctccct ggatgtggta gtgaacttga gactccagct   1200
 ctctgtgtcc aaggtgaagc ttcaggggac cacgtctgtg ctgggggatg tccagctcac   1260
 ggtggcctcc tccaacgtgg gcttcattga tacagatcag gtgcgcacac tgatgggcac   1320
 cgtttttgag aagcccctgc tggaccatct caatgctctc ttggccatgg gaattgccct   1380
 ccctggtgtg gtcaacctcc actatgttgc ccctgagatc tttgtctatg agggctacgt   1440
 ggtgatatcc agtggactct tctaccagag ctgaggcaag accactggga ggcctgagag   1500
 tgggccagct cgctgctcag gcgaatttct catttcaagc cactggggaa actgaggcaa   1560
 aaccatactt agtcatcacc aacaagctgg actgcttagc tgggctgttt tatcttccct   1620
 gagtgcctgg gtctccctcc ctcacttctg ccctttccct tcctcctcct cttctcctcc   1680
 ctcttccctc atctcccccc tccttcctct gccccacccc agcggggagc agactgctcc   1740
 tccaggctgt atagacctgc cctcttgcat taaacaactt ctcttgagct gcaaaaaaaa   1800
 aa                                                                  1802



      <210> 1387
      <211> 599
      <212> DNA
      <213> Homo sapiens


      <400> 1387
 acctactaca gtgactccat cttcttcctc tcgggcgcca tgcatcagat catgcccaaa     60
 gagatcctgc agatcattca gctggaccta gacctgaagt ttaagaccaa catccgggag    120
 ttgtttgagg aatttgacag tttcctgcca ggcgccatca tcggcatagc ccgggagatg    180
 cagccagttt acaggcacac attctggcag ttccgccatg agaaccccca gacccgggtt    240
 gggggcccgc cccccgaggg gctgccgggc ttcaacagcg gggtgatgtt gctgaacctg    300
 gaggccatgc gccagtcccc gctctacagc cgcctgctgg agccggcgca ggtgcagcag    360
 ctggccgaca agtaccactt tcgcggccac ctcggggacc aggacttctt caccatgatc    420
 sgcatggagc accccaagct cttccatgtg ctggactgta ccccgaaccg gcagstgtgs    480
 accyggtgga gggaccatkg gtacagtgac gkcttcgagg cctatttgag gtgtgagggc    540
 cacgtyaaga tctascacgg gactkgcaas actggcatcc cggggragta gggggtccc     599



      <210> 1388
      <211> 2389
      <212> DNA
      <213> Homo sapiens


      <400> 1388
 tttcgtctgt ccgcgttgcc agcaacctgt tttctttttt gaggcccggg ctgcggaggg     60
 ggagaagatg gggcgaatgg gagccgctgg attccctgag gacgcggagg gctagccaca    120
 gtgtagtccc agacaccctt ttcacctgca gcggctggta gtctccgcac cacccgctcc    180
 cactcgggtc ttctcccttc ctctgagagc tctgtgggga gtgtgaaacc ggagcgggat    240
 ggagctggcc tcctggagac actcatctcc aggaagcagg gcaggccaac ctaattccct    300
 agagggccga agagggaaag gaggggccct atgcttggac aggctcctcg cagctcggtt    360
 ccactttgtc ctccacagct gagaaggtga gctccctggg caagaactgg caccgcttct    420
 gcctgaaatg tgagcgctgc cacagcatcc tgtcccctgg cgggcatgca gagcacaatg    480
 ggaggccata ctgccacaag ccatgctatg gggctctctt tggacccagg ggccctcccc    540
 atatgaagac attcactggg gagacctcgc tgtgccctgg ctgtggggag cccgtctatt    600
 ttgctgagaa ggtgatgtca ttaggcagaa attggcaccg accgtgtctg aggtgccagc    660
 gttgccacaa gaccctgact gctgggagtc atgctgagca tgatggagtc ccctactgcc    720
 acgtcccctg ctacggctac ctgtttggcc ccaaaggtgt gaacattggc gatgtgggct    780
 gctacatcta tgacccagtg aagataaaat tcaaatgaga cgctcacaaa aaaggtcacc    840
 ctaactcagg cctcccatca tgcccctcat ggtccaatgg aagctacaaa aatctccagt    900
 cccatggggg ttggggaagg tgggatcttg ggggcctggg cctaggctcc atggtaggcc    960
 agagagtcta gactttctct gccaattttt tccctttccc atttctatct ggttagggaa   1020
 cagcccgttt tgaagggtat cctcctcctg gccatcacaa cccctttccc cagcacattc   1080
 tggagcttca aggtactcat aaaacttgtg tttattgaat ttcagcctct gtggcttctt   1140
 caataaaatg ttggctcccc atgccttcaa ctcttctttg ggcatgagac ccagtggttt   1200
 gggaggatgg ggaatgtggg ggttggggat gaacatgcaa ttgccctgca gggtgccctc   1260
 ggaggtagca gggccagccc atgagaacaa aaagctctgt tctttttgtc ccttgggcct   1320
 gggcattggc aagtcctaag caccacacaa gtggacaagc atgcccacca agccccattg   1380
 ggtacccaga agtctcatat gctaagtcct ttctttaggc acccatctct aggaggaagc   1440
 aggaagcacc ttatttcagg taacttcatt ttgagcatgg caacagatcc tatggtaagg   1500
 gcctcccaag aggttttcat ttatccattt ggggaggatg aacagactga ggcccagaga   1560
 agggaaagcc acatgcccaa ggttcacaca gcaagttaat ggtgaaggtt ttatcagagc   1620
 ccagggcaga ctcagtggct tcctatccag ggctcttccc acagctcgtc accactgccc   1680
 caacccaagg ggcaccttta tttacagaat cctccccaac cgtgagaggg gtgcccagca   1740
 gcccactgca ttctgggaag tcaactgttc ctagaagcca aataatcaag gatggatgag   1800
 cagagggagc gggtactggc agcaactccg gccctaggca gagggttcga tactcccagc   1860
 ctgagttgca gggcctgccc ttctgctctc ccagcccctg ctgcagagct tctgtggagg   1920
 gcctgcctcc actcccactt agttctggac ctgcttcatg ggcatctctt cctcctgaag   1980
 actggttggg gcactctttc tctccacgtc ctggatggtc tctggcagct gtgcctgcct   2040
 cgtctctggc agcaggaggg cggtgccggc agccagcagg gcgatccccc cataagtaag   2100
 cttgggcagt gacagccaca ctccatccag caaggccgcc agtggggcca aagagccccc   2160
 cagccggccc accagtgcag tcagccccat ccctgtctgt ctgagcaccg tagggtacaa   2220
 ctctgaagtg aacaggtagg cagtggtgaa ggcagcttca gaaaaagctt tccccatcac   2280
 tgccaggaca gtgctccagg acttcatatc ggaggacact agcagtctag tgccgaacgc   2340
 cagggccgtg cccagcagtg tcccggcttg cgtgaggcgg cgtcctgcg               2389



      <210> 1389
      <211> 718
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(718)
      <223> n = a,t,c or g


      <400> 1389
 aagaaggtgg gcaattacta cacaaccccg atctacaggt tccggatgaa atgccacctc     60
 tgtgtcaact acatcgagat gcagacggac cccgccaact gcgactacgt gatcgtgagt    120
 ggcgcccagc gcaaggagga gcgctgggac atggcggaca atgagcaggt gctgaccaca    180
 ggtgagcgcc acccacttac ctgcctgggg gccctggccc tgagtctgcg ctggggcccc    240
 caaagcccag ccgagctctg atcgttgcag agcatgagaa gaagcagaag ctggagacgg    300
 acgccatgtt ccggctggag catggcgagg ccgaccgcag cacactcaag aaggcgctgc    360
 ccacactgag ccacatccag gaggcccaga gcgcctggaa ggacgacttc gccctcaaca    420
 gcatgctgcg gagaaggttc cgggtgaggg gggctccagc ccggggtcag agaggatgca    480
 tggtggacca aggcccgggt ccagccctcc ccccaccaca tcctagcttt gagcaggcca    540
 cttgtacctt ctgagcctca gtttccccat ttgctacatg gtgccatgcc cctgtcttaa    600
 tccattctgg ctactataat accaaaatac catagacaga aacagtagaa aaaagaaagg    660
 gcacggtgac tcacgccttg tattgcggcc gctcggnngg tccncctaac gaaatgat      718



      <210> 1390
      <211> 2867
      <212> DNA
      <213> Homo sapiens


      <400> 1390
 tttttttttt ttaaaaatat tcagaaccaa gttttatttt gtagtcgtta cacaggaggg     60
 ggcagtcaga agagtacagc tcacccccag cagtggaggg gttaaatctc agggacaacg    120
 tggggcagtg gggacagcac ctccgaccct atggggtgta ccttcaagta gcaaggctga    180
 caatgatgtc tagaaaggtc tccacttctg cctgagtttt gccaaaccca gtggtctata    240
 gggatgtggc aaaagaatga cctaccgcag tgtgattatc agtgtttttt aaaataaaga    300
 gcacagtttt gcctttaaaa taattcacat caacggtatt tgggagaaca tggagctggc    360
 ataacattgg cgtagaaagc agggccaggc ccacccacgg ggccctcgtg tggggacggg    420
 tgcctgagcc cctgagcccc tcgagcctct ggccacggct ggctgcctgt gtgctgttgt    480
 ctcgtctgtc ccaccccgag aagggagttg aacaatgtga gttgtctgtg gcattggaaa    540
 gtgcagtggt tacatgggtg tgtgcgaagt ggttagctgt gccttcaggc ggtgcgtcta    600
 gcagggctga tgggggccag ggctgctcct ggctttttgt gggcagggct tgccctccag    660
 ggaccccgag tgcttgcacc cgctcggtga cagtggctgg caggtctaag tgctgctgct    720
 ggatgcaaat tcctttggta gacttttttt tttttaagaa aaaaataaaa ccaatttttg    780
 ggttggcacc tgaggtaata agttaagaat aagcaccaaa atggcccttc ctggcacgcg    840
 ccggctcaca ggttcttcat gcacacctgg cagcggctga tgtgtgtgcg gatgaggccg    900
 gccttgagcg tgtcggcgga gggcgagccc tggaagctct gctcgggaat ggtggtcagc    960
 cagaagctgt acttgttggc gtagtagtgg caggtgccgc ggcctccatt gcattcgatg   1020
 aatggtgtgg cgcggaagtc ctctagacag ctgcccggtg acaccagtga ttggccaccg   1080
 ccttcgtctc ccgccgccgt gtgcatgagg aaggaatatc cgatccacaa actccgccac   1140
 ccagctgggc agtgtgggat ggagacatcc tgactgtgga ccgcgatggc gatggccggg   1200
 gcctcacaca cagaacagcg gctgatgtag ggcttgatct cgtcctcggc cacgggcatc   1260
 atgggcagcg gcgcagtggt agagagccag taggacttgt cgttccggct ggcatagtag   1320
 cagacatcac cagggttgca gtacaggaag ggcatggtgc tgaaccgcgc caggcaggag   1380
 cccgccagcc ccaggtcctg gttgtgcgcc ttctcctggc cctcgaagta cagcaggctg   1440
 tatccactcc agagtttgtt catgcccacc gggcacatgg gctcctggtc cgtctggctg   1500
 tgcttcacca ggaggtagcc gatgctgacg ctgcggcctg gcatacccgg caggcccggg   1560
 ctccctggac ggcctggtgc accttcttgg ccaatcggcc cctggtggcc tatgggtcct   1620
 tcatctcccc ggaagccggg aacagcagac acaccacctc ttccttgggg cccagctttc   1680
 cctggagccc cacgaaaacc tggttctccg ggggggccct ggggccccat ctcccccggt   1740
 gccccagggg ggcctcgcct cccctgggga cccactgtcc ctggttggac ggcaatcttc   1800
 tgggggattc ctgcaatccc gggggctccc acagtcccgg gggcaccagg gaatcctggg   1860
 tctcccttgg gtcccttggg gcctctgtcg cccaccgccc cggtgggtcc agtgttcccc   1920
 atgaagcctt gttcacccct gggccctttt tctcctggga gaccaaacac accaggcctg   1980
 ccctggggcc cggagtcccc ggcccatcct ttggtccctg gggttcctgg agctcctggg   2040
 ttccctgtgt cacctttgct tccaggaaga gcagcagaac ctggtggccc tggtgggccc   2100
 cgataacctt tcaggccaaa tatccctggc gcccctttgt caccaggtgc cccagagatg   2160
 ttggaagggg gtgtgatgcc tgggaacccc tgaagtcctg ggctcccagg tgggcctcgt   2220
 tcccctggag ctccttggtc tcctttctgt cctgggactc ccacagggcc tggaagggtg   2280
 ttggcctctc ctgggtcacc tctttcccca ggagggcctg ggaagcctgg gtctccgtgg   2340
 atgtcagaac ctggggatcc tggaaagccc ttggtgcctg gcaagccgtg taagccgcgg   2400
 atcccacgga gtcccggaaa acctggtaag cccggagctc ccggccagcc atcatctcct   2460
 ttgccaccag gcagtccaat ccgccccagc tctccctgcg accctggagg cccagtcagc   2520
 cctggaaagc ctgtttgtcc tttaagtcca ggagggcctt ggactccagt cacgcctgtt   2580
 atcccaggga agccgatgtc accttctgtt cccttctctc caaagaatcc cttcagacct   2640
 ggtattccag tggtgccccg ctcccccttc aggcctggtc ttcctggtaa atttatagtg   2700
 tccccgatgt caccgaaatc accagtcgcg ccaatctcgc catacaggcc tgctctccct   2760
 ggggcacctt tgtcaccccg gcttcctatg aatcctggga atcccgtaat tccagggggg   2820
 ccagccaccc cagggaatcc tggcaaaccg gggatgccgg ggaggcc                 2867



      <210> 1391
      <211> 777
      <212> DNA
      <213> Homo sapiens


      <400> 1391
 cttatttata atgaagatat gatttgttgg attgaatcaa gagaatcttc aaatcaactc     60
 aaatgtatcc agataacaaa agcaggagga ttaacagatg aatggacaat caatattctt    120
 caatccttcc acaatgtgca acaaatggcg attgactggc tcactcgaaa tctctatttt    180
 gtggaccatg tcggtgaccg gatctttgtt tgtaattcca acggttctgt atgtgtcacc    240
 ctgattgatc tggagcttca caatcctaaa gcaatagcag tagatccaat agcaggaaaa    300
 cttttcttta ctgactacgg gaatgtcgcc aaagtggaga gatgtgacat ggatgggatg    360
 aaccgaacaa ggataattga ttcaaagaca gagcagccag ctgcactggc actagaccta    420
 gtcaacaaat tggtttactg ggtagatctt tacttggact atgtgggagt agtggactat    480
 caaggaaaaa atagacacgc tgtcattcaa ggcagacaag tcagacatct ttatggtata    540
 actgtgtttg aagattattt gtatgcaacc aattctgata gctacaatat cgtaaggata    600
 agccgattta atgggactga tattcactca ttaattaaaa ttgagaatgc ttggggaatc    660
 cgaatttatc aaaaaagaac tcaaccaaca gtcagaagcc atgcatgtga agtcgatcca    720
 tatggaatgc cagggggctg ttcacacatc tgtctactca gcagcagtta cacgaaa       777



      <210> 1392
      <211> 777
      <212> DNA
      <213> Homo sapiens


      <400> 1392
 cttatttata atgaagatat gatttgttgg attgaatcaa gagaatcttc aaatcaactc     60
 aaatgtatcc agataacaaa agcaggagga ttaacagatg aatggacaat caatattctt    120
 caatccttcc acaatgtgca acaaatggcg attgactggc tcactcgaaa tctctatttt    180
 gtggaccatg tcggtgaccg gatctttgtt tgtaattcca acggttctgt atgtgtcacc    240
 ctgattgatc tggagcttca caatcctaaa gcaatagcag tagatccaat agcaggaaaa    300
 cttttcttta ctgactacgg gaatgtcgcc aaagtggaga gatgtgacat ggatgggatg    360
 aaccgaacaa ggataattga ttcaaagaca gagcagccag ctgcactggc actagaccta    420
 gtcaacaaat tggtttactg ggtagatctt tacttggact atgtgggagt agtggactat    480
 caaggaaaaa atagacacgc tgtcattcaa ggcagacaag tcagacatct ttatggtata    540
 actgtgtttg aagattattt gtatgcaacc aattctgata gctacaatat cgtaaggata    600
 agccgattta atgggactga tattcactca ttaattaaaa ttgagaatgc ttggggaatc    660
 cgaatttatc aaaaaagaac tcaaccaaca gtcagaagcc atgcatgtga agtcgatcca    720
 tatggaatgc cagggggctg ttcacacatc tgtctactca gcagcagtta cacgaaa       777



      <210> 1393
      <211> 1697
      <212> DNA
      <213> Homo sapiens


      <400> 1393
 tttcgtgtgg tgggctgcgg gtaggggagg ggatggaccg agtcccggct tgtcgggatg     60
 agggttccgg aagatctggc cagtaagatt ctactccctg gctgtgcacc gggttcccta    120
 cccctgtcta cgtcggctcc gccacttcgc ggcttgagac taaaagagca tcccggcagg    180
 gggccttcca gccccaaagc agcctgtcca gagaccccca aattctgatc ctgaagttgg    240
 aggcctccgg ggatgttctt ttttaatctt ttaaaagggt tagaggggtt gaggctgcct    300
 gaccccagcc taatggggta ggtaggcctt gggaagtgga gcatgggggc aaaggatcca    360
 agcattgagc cttcatcctc tattccccat ccagtggggt gccgaggctc aggcagcatg    420
 acgacggaga cctttgtgaa ggatatcaag cctgggctca agaatctgaa ccttatcttc    480
 attgtgctgg agacaggccg agtgaccaag acaaaggacg ggcatgaggt tcggacctgc    540
 aaagtggcgg acaaaacagg cagcatcaat atctctgtct gggacgatgt tggcaatctg    600
 atccagcctg gggacattat ccggctcacc aaagggtacg cttcagtttt caaaggttgt    660
 ctgacactat atactggccg tgggggtgat ctgcagaaga ttggagaatt ctgtatggtt    720
 tattctgagg ttcctaactt cagtgagcca aacccagagt acagcaccca gcaggcaccc    780
 aacaaggcgg tgcagaacga cagcaaccct tcagcttccc agcctaccac tggaccctct    840
 gctgcctctc cagcctctga gaaccagaat gggaatggac tgagtgcccc accaggtccc    900
 ggtggtggcc cacatccccc tcatactccc tcccacccac ccagcacccg aatcactcga    960
 agccagccca accacacacc tgcaggcccg cctggccctt ccagcaaccc tgttagtaac   1020
 ggcaaagaaa cccggaggag cagcaagaga tagcatgaca ttctttcttc ctgccaccaa   1080
 ccacatccca agtgtcccct ggagagcaag atagccttcc actgattggc tggtgtagca   1140
 gtattttagc cactgaactt cagtggaggg tggtgagcag tgtccttatc caccctaatc   1200
 tcatactccc tcattgtcca gctgaactac ctgtcccctg ggagtcagga ccctctgcct   1260
 gctctctttc ctctttagaa atggcagtta ctggctgggc gcagtggctc acgcttgtaa   1320
 tcccagcact ttgggaagcc gaggtgggcg gatcacctga ggtcgggagt tcaagaccag   1380
 cctgaccaac atggagaaac cccgtgtcta ctaaaaatac agaattagcc aggcatggtg   1440
 gcgtatgcct gtaatcccag ctacttagga ggctgaggca ggagaatctc ttgaaaccgg   1500
 gaggcggagg ttgaggtgag ccgaaattgc accattgcac tccagcctgg gcaataagag   1560
 cgaaactcca tctcaaaaaa aaaagaaaga aagaaagaaa gaaagaaaga aatggcagtt   1620
 accatctgtt tcttctgtgt gagacatggg agtctaactg aagtctctcc ttcctaataa   1680
 atgttaccac ttctaaa                                                  1697



      <210> 1394
      <211> 852
      <212> DNA
      <213> Homo sapiens


      <400> 1394
 ggcttccatc ctaatacgac tcactatagg gctcgagcgg ccgcccgggc aggtgctggg     60
 tcgtttgtgg gcgaagtaag tgctgtagat aaagactttg ggccaaatgg agaagtaagg    120
 tattcttttg aaatggtgca gccagatttt gagttgcatg ccatcagtgg ggaaattaca    180
 aatactcatc agtttgacag ggagtctctt atgaggcgga gagggactgc tgtgtttagc    240
 tttacagtca tagcaacaga tcaggggatc cctcagcctc tcaaggatca ggccactgta    300
 catgtttaca tgaaggatat aaatgataat gctcccaaat ttttaaaaga cttttaccaa    360
 gctacaatat cagaatcagc agccaatctg acacaagtgt taagagtatc tgcctcagat    420
 gttgatgaag gtaataatgg acttattcac tattctataa taaaaggaaa tgaagaaaga    480
 cagtttgcta tagacagtac ctctggtcag gtaacactaa ttggcaaatt agactatgaa    540
 gcaacacctg cctattccct tgtaattcaa gcagtggatt cagggacaat ccccctcaat    600
 tcaacgtgta ctttaaatat tgatatttta gatgaaaatg acaatacccc tttctttccc    660
 taaatcaaca cttctttgtt gatgttttgg aaaacatgag aattggtgaa ctcggggcct    720
 ctggtactgc aactgattcc cgattcaggt gacattgctg atttatatta caagtttact    780
 gggactaaac acccccccgg aacttttagc attagcccca aacacttggg agtatttttc    840
 ttggcccaaa aa                                                        852



      <210> 1395
      <211> 852
      <212> DNA
      <213> Homo sapiens


      <400> 1395
 ggcttccatc ctaatacgac tcactatagg gctcgagcgg ccgcccgggc aggtgctggg     60
 tcgtttgtgg gcgaagtaag tgctgtagat aaagactttg ggccaaatgg agaagtaagg    120
 tattcttttg aaatggtgca gccagatttt gagttgcatg ccatcagtgg ggaaattaca    180
 aatactcatc agtttgacag ggagtctctt atgaggcgga gagggactgc tgtgtttagc    240
 tttacagtca tagcaacaga tcaggggatc cctcagcctc tcaaggatca ggccactgta    300
 catgtttaca tgaaggatat aaatgataat gctcccaaat ttttaaaaga cttttaccaa    360
 gctacaatat cagaatcagc agccaatctg acacaagtgt taagagtatc tgcctcagat    420
 gttgatgaag gtaataatgg acttattcac tattctataa taaaaggaaa tgaagaaaga    480
 cagtttgcta tagacagtac ctctggtcag gtaacactaa ttggcaaatt agactatgaa    540
 gcaacacctg cctattccct tgtaattcaa gcagtggatt cagggacaat ccccctcaat    600
 tcaacgtgta ctttaaatat tgatatttta gatgaaaatg acaatacccc tttctttccc    660
 taaatcaaca cttctttgtt gatgttttgg aaaacatgag aattggtgaa ctcggggcct    720
 ctggtactgc aactgattcc cgattcaggt gacattgctg atttatatta caagtttact    780
 gggactaaac acccccccgg aacttttagc attagcccca aacacttggg agtatttttc    840
 ttggcccaaa aa                                                        852



      <210> 1396
      <211> 1608
      <212> DNA
      <213> Homo sapiens


      <400> 1396
 gggttccgtg gccctgcacg tggagaagct gcccaatgag cccaaccgct tgcttatcct     60
 ccacggcttc ctggacgaaa acgtgcactt tttccacaca aacttcctcg tctcccaact    120
 gatccgagca gggaaacctt accagctcca ggtggccctg cctcctgtct ccccgcagat    180
 ctaccccaac gagagacaca gtattcgctg ccccgagtcg ggcgagcact atgaagtcac    240
 gttgctgcac tttctacagg aatacctctg agcctgccca ccgggagccg ccacatcaca    300
 gcacaagtgg ctgcagcctc cgcggggaac caggcgggag ggactgagtg gcccgcgggc    360
 cccagtgagg cactttgtcc cgcccagcgc tggccagccc cgaggagccg ctgccttcac    420
 cgccccgacg ccttttatcc ttttttaaac gctcttgggt tttatgtccg ctgcttcttg    480
 gttgccgaga cagagagatg gtggtctcgg gccagcccct cctctccccg ccttctggga    540
 ggaggaggtc acacgctgat gggcactgga gaggccagaa gagactcaga ggagcgggct    600
 gccttccgcc tggggctccc tgtgacctct cagtcccctg gcccggccag ccaccgtccc    660
 cagcacccaa gcatgcaatt gcctgtcccc cccggccagc ctcccccact tgatgtttgt    720
 gttttgtttg gggggatatt tttcataatt atttaaaaga caggccgggc gcggtggctc    780
 acgtctgtaa tcccagcact ttgggaggct gaggcgggcg gatcacctga ggttgggagt    840
 tcaagaccag cctggccaac atggggaaac cccgtctcta ctaaaaatac aaaaaattag    900
 ccgggtgtgg tggcgcgtgc ctataatccc agctactcgg gaggctgagg caggagaatc    960
 gcttgaaccc gggaggtgga ggttgcggtg agccaagatc gcaccattgc actccagcct   1020
 gggcaacaag agcgaaactc tgtctcaaaa taaataaaaa ataaaagaca gaaagcaagg   1080
 ggtgcctaaa tctagacttg gggtccacac cgggcagcgg ggttgcaacc cagcacctgg   1140
 taggctccat ttcttcccaa gcccgagcag agggtcatgc gggccccaca ggagaagcgg   1200
 ccagggcccg cggggggcac cacctgtgga cagccctcct gtccccaagc tttcaggcag   1260
 gcactgaaac gcaccgaact tccacgctct gctggtcagt ggcggctgtc ccctccccag   1320
 cccagccgcc cagccacatg tgtctgcctg acccgtacac accaggggtt ccggggttgg   1380
 gagctgaacc atccccacct cagggttata tttccctctc cccttccctc cccgccaaga   1440
 gctctgccag gggcgggcaa aaaaaaaagt aaaaagaaaa gaaaaaaaaa aaaaagaacc   1500
 aacccacctc tacatattat ggaaagaaaa tatttttgtc gattcttatt cttttataat   1560
 tatgcgtgga agaagtagac acattaaacg attccagttg gaaacatg                1608



      <210> 1397
      <211> 439
      <212> DNA
      <213> Homo sapiens


      <400> 1397
 acattttgtt tgcttttcca ttaatccact ggtttagttt ccagaacgca atgtcagacc     60
 tgaggtgaca gaaaagggaa aacgtgagag agtgtcttct tccctgaaga gaggtgggcc    120
 tgaggcttga cagtggcgct gcctgagtga cctagccgct gggctgggcc ctggacagct    180
 gatcccaggt tcctgcactt gtcgccaccc ttccgtagtc cacaggcctg atggcggcgg    240
 cggctgagcc gatgggcccg gcacaggttc ccatgaactc agaagtaatt gtggacccta    300
 tacagacaca agcagcaagt ccaacacaat cacagcaaca gactctcctg cagaccttcc    360
 caggaagaca gagccacaca caccatcatg gtcctggaca aggaaaacac tctttcctaa    420
 tctggttgtc atgccatga                                                 439



      <210> 1398
      <211> 958
      <212> DNA
      <213> Homo sapiens


      <400> 1398
 cccggaattt ccgggtcgac gatttcgtcg ctgagcttaa actgaagcaa gttcggtgga     60
 cgccggcggc gccctgatct aaagaaacga ctcagggact gcggcgcttg cacgtcaacg    120
 ggaggtgtga gcccaaaggt ctggacccag aaatgggacg tcggtcatca gatactgaag    180
 aagaaagcag aagcaagaga aaaaagaaac accgtagacg gtcctcctcg agcagttctt    240
 cagatagtag aacatacagc cgaaagaaag gaggaaggaa atcaagatca aagtcaagat    300
 cttggtccag agatcttcag cctcgttcac attcttatga tagaagacgc aggcatcgat    360
 caagcagtag ctcttcttat ggctccagaa ggaaacgaag tcgaagtcgt tcaaggggtc    420
 gagggaaatc ctatagagtt cagaggtcta ggtcaaaaag cagaacaaga aggtccaggt    480
 caagacctcg tctccgttct catagtcgta gcagtgaaag gtccagtcac agaagaacgc    540
 gtagtcggtc tcgggataga gaacgacgta agggcagaga taaagagaaa agagaaaagg    600
 agaaggataa agggaaggac aaggaattac ataacatcaa acgtggggaa tctggaaaca    660
 tcaaagctgg attagaacat ctgccaccag ctgaacaggc caaagccaga ctacagctgg    720
 ttcttgaagc tgctgcaaaa gctgatgaag cattgaaagc caaagaaaga aatgaggaag    780
 aagcaaagag aagaaaggag gaagaccaag ccaccctggt agaacaagta aaaagagtaa    840
 aagaaattga agctattgaa agtgattctt ttgttcagca gacattcaga tcaagtaaag    900
 aagtcaaaaa gtcagtggaa cctaatggag tgaaacaggc acctttaaca tcaggacg      958



      <210> 1399
      <211> 762
      <212> DNA
      <213> Homo sapiens


      <400> 1399
 atcattacgc caagcttggc acgagggtgt atgctgtaac atgaccacag ttgggaagct     60
 gcagagttca ccaacttttc tggggatcag cttttctttt tctcaacggt aacttaagaa    120
 accacctaaa aataaaatat actttaatta ttcccactag catcctactg tgtctgcttg    180
 tctgctttcc atgctctttc ctgggagtaa tgagatccac aagcagaaga gtaaccagaa    240
 aggatcaaat gtctttgcgt tgcttcattt tctgttaggt gggaaacttt cagcgacaat    300
 tggcagaagc taaagaagac aactgcaaag tcacaatcat gttggagaat gtgctggctt    360
 ctcacagtaa gatgcaaggt gctctggaga aagtacaaat agagcttggg cggagggatt    420
 cagagattgc aggcctcaag aaagaaaggg atctcaatca acagagggtg cagaagctgg    480
 aagctgaagt ggaccagtgg caggccagga tgcttgtcat ggaggaccag cacaacagtg    540
 agattgaatc tctacaaaaa gctctaggtg tagctagaga agacaacagg aaacttgcta    600
 tgagtctgga acaagctctc cagacaaata atcatctgca aacaaagcta gatcacattc    660
 aagagcaatt ggaaagcaaa gaacttgagc gacagaattt ggaaaccttc aaagaccgga    720
 tgactgaaga gtccaaagtg gaagcagaat tgcatgctga ac                       762



      <210> 1400
      <211> 1434
      <212> DNA
      <213> Homo sapiens


      <400> 1400
 caccaccaaa tatggacaat tcaatgggga cagaggaaat cacagttctc aaaggtagtt     60
 ccacctctat ggcatgcatt actgatggaa ccccagctcc cagtatggcc tggcttagag    120
 atggccagcc tctggggctt gatgcccatc tgacagtcag cacccatgga atggtcctgc    180
 agctcctcaa agcagagact gaagattcgg gaaagtacac ctgcattgcc tcaaatgaag    240
 ctggagaagt cagcaagcac tttatcctca aggtcctagt tcctccaagt tttcagaaac    300
 tctgggaaat aggaaacatg ctagatactg gcaggaatgg tgaagccaaa gatgtgatca    360
 tcaacaatcc catttctctt tactgtgaga caaatgctgc tccccctcct acactgacat    420
 ggtacaaaga tggccaccct ctgacctcaa gtgataaagt attgattttg ccaggagggc    480
 gagtgttgca gattcctcgg gctaaagtag aagatgctgg gagatacaca tgtgtggctg    540
 tgaatgaggc tggagaagat tcccttcaat atgatgtccg tgtactcgtg ccgccaatta    600
 tcaagggagc aaatagtgat ctccctgaag aggtcaccgt gctggtgaac aagagtgcac    660
 tgatagagtg tttatccagt ggcagcccag caccaaggaa ttcctggcag aaagatggac    720
 agcccttgct agaagatgac catcataaat ttctatctaa tggacgaatt ctgcagattc    780
 tgaatactca aataacagat atcggcaggt atgtgtgtgt tgctgagaac acagctggga    840
 gtgccaaaaa atattttaac ctcaatgttc atgttcctcc aagtgtcatt ggtcctaaat    900
 ctgaaaatct taccgtcgtg gtgaacaatt tcatctcttt gacctgtgag gtctctggtt    960
 ttccacctcc tgacctcagc tggctcaaga atgaacagcc catcccactg aacacaaata   1020
 ctctcattgc gcctggtggt cgaactctac agattattcg ggccaaggta tcagatggtg   1080
 gtgaatacac ttgtatagct atcaatcaag ctggcgaaag caagaaaaag ttttccctga   1140
 ctgtttatgt gcccccaagc attaaagacc atgacagtga atctctttct gtagttaatg   1200
 taagagaggg aacttctgtg tctttggagt gtgagtcgaa cgctgtgcca cctccagtca   1260
 tcacttggta taagaatggg cggatgataa cagagtctac tcatgtggag attttagctg   1320
 atggacaaat gctacacatt aagaaagctg aggtatctga cacaggccag tatgtatgta   1380
 gagctataaa tgtagcagga cgggatgata aaaatttcca cctcaatgta tatg         1434



      <210> 1401
      <211> 1333
      <212> DNA
      <213> Homo sapiens


      <400> 1401
 ccgaagtgga gaagggttcc atgtgaacag cagttgaaca tgggtcagtc ggtcctgaga     60
 gatggacgag acgccgggat ccgaggtgcc gggtgacaag gccgccgagg aacagggaga    120
 tgaccaggat agtgaaaagt caaaaccagc aggctcagat ggtgagcggc ggggggtaaa    180
 gagacagcgg gatgagaagg atgaacatgg ccgagcttac tatgaattcc gagaggaggc    240
 ttaccacagc cgctcaaagt ctccactgcc tcctgaagaa gaggcaaaag atgaggagga    300
 ggatcaaact cttgtgaacc tggacacgta tacctcggat ctgcattttc aagtgagcaa    360
 agaccgctat ggagggcagc cacttttctc agagaagttc cccacccttt ggtctggggc    420
 aaggagtact tacggagtga caaagggaaa agtctgcttt gaggcaaagg taacccagaa    480
 tctcccaatg aaagaaggct gcacagaggt ctctctcctt cgagttgggt ggtctgttga    540
 tttttcccgt ccacagcttg gtgaagatga attctcttac ggtttcgatg gacgaggact    600
 caaggcagaa aatggacaat ttgaggaatt tggccagact tttggggaga atgatgttat    660
 tggctgcttt gctaattttg agactgaaga agtagaactt tccttctcca agaatggaga    720
 agacctaggt gtggcattct ggatcagcaa ggattccctg gcagaccggg cccttctacc    780
 ccatgtcctc tgcaaaaatt gtgttgtaga attaaacttc ggtcagaagg aggagccctt    840
 cttcccacca ccagaagagt ttgtgttcat tcatgctgtg cctgttgagg agcgtgtacg    900
 cactgcagtc cctcccaaga ccatagagga atgtgaggtg attctgatgg tgggactacc    960
 cggatctgga aagacccagt gggcactgaa atatgcaaaa gaaaaccctg agaaaagata   1020
 caatgtcctg ggagctgaga ctgtgctcaa tcaaatgagg atgaagggtc tcgaggagcc   1080
 agagatggac cccaaaagcc gagacctttt agttcagcaa gcctcccagt gccttagtaa   1140
 gctggtccag attgcttccc ggacaaagag gaactttatt cttgatcagt gtaatgtgta   1200
 caattctggc caacggcgga agctattgct gttcaagacc ttctctcgga aagtggtggt   1260
 ggttgtccct aatgaggatg attggaagaa gaggctggag ttgaggaagg aagtagaggg   1320
 gagggtattc ccg                                                      1333



      <210> 1402
      <211> 1060
      <212> DNA
      <213> Homo sapiens


      <400> 1402
 attatttttc ttttctttta gccatacctt cagagtgtta ttttcctttt tgtcataagg     60
 ggtctggaaa tgaagtatgg aaatgaaata atgaataaag acccagtttt cagaatctct    120
 ccacggagta gagaaactca tcccaatccg gaagagcccg aagaagaaga tgaagatgtt    180
 caagctgaaa gagtccaagc agcaaatgca ctcactgctc caaacttgga ggaggaacca    240
 gtcataactg caagctgttt acacaaggaa tattatgaga caaagaaaag ttgcttttca    300
 acaagaaaga agaaaatagc catcagaaat gtttcctttt gtgttaaaaa aggtgaagtt    360
 ttgggattac taggacacaa tggagctggc aaaagtactt ccattaaaat gataactggg    420
 tgcacagtgc caactgcagg agtggtggtg ttacaaggca acagagcatc agtaaggcaa    480
 cagcgtgaca acagcctcaa gttcttgggt actgccctca ggagaactca ctgtgtccca    540
 aacttacaat gaaagagcat ttggagttgt atgcagccgt gaaaggactg ggcaaagatg    600
 ctgctcttag tatttcatga ttggtggaag ctctcaagct ccaggagcaa cttaaggctc    660
 ccgtgaaaac tctatcagag ggaataaaga gaaagctatg cttcgtgctg agcatactgg    720
 ggaacccatc agtggtgctt ctagacgagc tgttcaccgg gatggaccct gaggggcagc    780
 agcaaatgtg gcagatactt caggctacca ttaaaaacca ggagaggggc gccctcttga    840
 ccacccatta catgtcagag gctaagtctc tgtgtgaccg tgtggccatc atggtgtcag    900
 gaacgctaag gtgtattggt tccattcaac agctgaaaag tttggtaaag attatttact    960
 agaaataaaa atgaaagaac ctactcaggt ggaagctctc cacacagaga ttttgaagct   1020
 tttcccacag gctgcttggc aggaaagata ttcctcttta                         1060



      <210> 1403
      <211> 2543
      <212> DNA
      <213> Homo sapiens


      <400> 1403
 acgatttcgt cgagtccaaa atggcggctc tcaggctggc gcgctccgtg ctgctggggc     60
 tttgaggtgg tcgccggggg tccgggggac cctttccccg ccgcggaagc cctagaggat    120
 gaatcgggga ccctgctaag gtctggcggc ggggctggag agcagtggca gcaagggctg    180
 cggtggcgtc cacgcagcgg gatgtgcgag agttactcca ggtcgttgtt gagggtctcg    240
 gtggcgcaga tctgccaggc gctgggctgg gactcggtgc agctcagcgc ctgccacctc    300
 ctcacggacg tgctgcagcg ctatctgcag cagctgggcc ggggctgcca tcggtactct    360
 gagctctatg gccgaacaga cccaattttg gatgatgttg gtgaagcttt ccagctgatg    420
 ggggttagtc tacatgaact agaagactat attcacaaca ttgagcctgt caccttccca    480
 caccaaattc cgtcatttcc tgttagcaag aacaatgtac ttcagtttcc tcaacctgga    540
 agtaaagatg cagaggaaag aaaagaatac attcctgatt acctgccacc cattgtgtct    600
 tctcaagaag aagaagaaga agagcaggtg cccactgatg gaggcacatc agcagaagcc    660
 atgcaggttc ccttggaaga agatgatgaa ttggaggagg aagaaattat taatgatgag    720
 aatttcctgg gcaagagacc actggatagt cctgaagctg aagaactgcc agccatgaag    780
 cggcctcggc tattaagcac taaaggggac acgctagatg ttgtgttatt ggaagctcga    840
 gagccactca gctcaataaa tactcaaaag atcccaccaa tgctttctcc agtccatgta    900
 caggacagta cagacttggc acctccctca cccgagccgc caatgttggc tccagttgca    960
 aaatcacaaa tgccaactgc aaaaccatta gaaacaaagt catttacacc taaaacaaag   1020
 actaaaacta gctctccagg acagaagact aaatcaccta aaaccgccca gtcaccagca   1080
 atggtcggaa gtcctattcg atcaccaaaa actgtatcca aagaaaagaa atcacctgga   1140
 cgttccaaga gccccaagag tcccaagagc cccaaggtca cgactcacat tccccaaaca   1200
 cctgtgagac ctgaaacgcc caacaggact ccttcagcta cactcagtga aaaaatcagt   1260
 aaagagacta tccaggtaaa acaaatacag acaccccctg atgctgggaa actgaacagt   1320
 gagaatcagc cgaaaaaggc tgtggtagca gataaaacga ttgaggcctc tatcgatgct   1380
 gtgattgcac gagcctgtgc tgagcgagag ccagatcctt tcgaattttc ttctggatcg   1440
 gaatctgaag gagacatttt tactagccct aagagaattt caggcccgga gtgtactact   1500
 cccaaagctt ccacttccgc gaacagtttc acaaagtcag gatccactcc tctgcctctt   1560
 tccggtggaa cctcaagttc cgataactca tggacaatgg atgcctccat tgatgaggtt   1620
 gtacgtaaag caaaactggg aacaccttca aatatgcccc ccaactttcc ttatatctct   1680
 tctccgtcag tgtctcctcc cactcccgaa cctctccaca aggtgtatga ggagaaaacc   1740
 aagctgcctt cctccgtgga ggtaaagaag aagttgaaaa aggaactaaa gactaaaatg   1800
 aaaaagaaag aaaagcagag agatagggag agggaaaaag acaagaacaa ggacaaaagt   1860
 aaggagaagg ataaagtgaa agagaaagag aaagacaagg aaactggcag ggaaacaaag   1920
 tatccctgga aggaatttct taaagaggaa gaggcagatc cctacaagtt taaaatcaaa   1980
 gaatttgaag atgttgatcc caaagtgaaa ttgaaagatg gacttgtgag gaaggagaaa   2040
 gagaagcata aagataagaa gaaagataga gagaaaggca agaaagataa agataagaga   2100
 gagaaagaaa aagtgaaaga taaaggcaga gaagataaga tgaaagcccc agcaccccca   2160
 ctggtgttgc ccccaaaaga gttggccctg cccttgttca gccctgccac agcctccagg   2220
 gtcccagcca tgctgccatc tttgttgcca gtgcttccgg aaaaactgtt tgaggagaaa   2280
 gagaagccga aggagaaaga aaagaaaaag gacaaaaagg agaagaagaa aaagaaggaa   2340
 aaagagaagg agaagaagga gaaggaaaga gagaaagaga agagagagcg agagaagaga   2400
 gaaaaagaga aggagaaaca caagcatgaa aaaataaaag tggaaccagt cgctctggcc   2460
 ccgagtccag ttatccccag attaactctc cgagtcggtg ctggccccga caagataaga   2520
 agaagaagag caggtgccca ctg                                           2543



      <210> 1404
      <211> 2202
      <212> DNA
      <213> Homo sapiens


      <400> 1404
 tcaaaatgaa aattcagtgg acaagtgggg aaaaccttta gtgattgata aactcaagga     60
 aatggccaaa gtcgagggtc tctggaactt gtttttgcca gctgtcagcg gactcagcca    120
 cgtggactat gccttgattg ctgaagaaac aggaaaatgc ttttttgctc cagatgtctt    180
 taactgccaa gcaccagaca cagggaatat ggaggttctg cacctgtatg gaagtgagga    240
 acagaagaaa cagtggcttg agcctcttct tcaagggaac attacctctt gcttctgtat    300
 gacagaacct gatgtagctt caagtgatgc cacgaatatt gaatgcagca tccaacgaga    360
 tgaagatagc tatgtaatta acggcaaaaa atggtggagc agtggagctg ggaatcccaa    420
 gtgcaaaatt gcaattgttt tgggaagaac tcaaaatact tctctctcca ggtaattaaa    480
 caattctgat tgagaaacct gtgtaggaat gagccagtct tcctcctatc taggtaattt    540
 acttaaaatt cactgtttgg actcacaaat cataatgtaa gatatgagag taaatgtcat    600
 atatttgtat ttcacaagta ttttctaaca ggtgtttttg gaaaacatta tagggagtat    660
 tgctgaacat tcttcgctgt ggaattttca gtattagaaa gtgttgctaa attatcaaag    720
 ctgtttggat taaattatca gacaaatttt ttcagacctg tgtaatgaag tgattagatg    780
 tttagatcaa aggcaataat cttgaaatgt ttaattatat atataagttc ccagttacca    840
 ttgttgagca gtgagaagct tcaatcaaac aactcattta ttttcaaatc attgtttctg    900
 ttccagatca cagcctgcat cagactatgt tggtgtacgt cttttacaca gttcccattc    960
 cagtcatcac tgcttacatg actacatgaa aacatcaaaa agacaattgg gattctgctt   1020
 attatctgtt ttatttttct tcttagcaaa ctttttctaa tacaattttt cttttgacta   1080
 gacacaaaca gcacagcatg attcttgttc ccatgaacac acctggagta aaaataataa   1140
 ggcctttgtc agtttttggc tacacagata attttcatgg aggacatttt gagatccatt   1200
 ttaatcaagt gcgagttcct gccacaaatc taatactagg tgaaggtagg ggatttgaaa   1260
 tttcccaagg ccgccttgga cctggcagaa tccaccactg tatgagaaca gtaggtttgg   1320
 cggaacgcgc tttgcagatc atgtgtgagc gggcaacaca aaggatagct ttcaagaaga   1380
 agttgtatgc acatgaggtt gtggctcact ggattgctga aagccgcatt gccattgaga   1440
 agatccgctt gttgactctg aaagctgctc acagcatgga cactctgggc agtgctggcg   1500
 ctaagaaaga gattgcaatg atcaaagtgg ctgccccacg ggctgtcagc aaaatcgttg   1560
 actgggccat ccaggtgtgc ggaggtgctg gtgtttccca ggattaccct ctggctaaca   1620
 tgtatgctat aacccgagtt ttgcgtttag cagatggacc tgacgaagtt catctttcag   1680
 caatcgcaac aatggagctg cgggaccaag ccaaaagact gacagccaag atataaggag   1740
 ggtggcactg ccacatccca ctggcagaaa ctctccttta tacaaacttc attggctcca   1800
 acatttgaat ctcatatttt tgtagcagtt tgagcacagg gttaattatt catttgtggt   1860
 aaagattata gcatctattt tgatcagtgg gttttattat ttcaagggtc acacagggtt   1920
 aagttcagta agaaatgctg tagctgttgt cattcaatct agtgcctcct tgaggccagg   1980
 agttcaggac cagcctgggc aacatagcga gacccccatt gctacaaaaa atttaaaaat   2040
 gaaacaagtg tggtggcaca tgcttgtagt cctagctact tgggaggctg aggcaggagg   2100
 attgcttgag tctaggagtt tgaggttaca gtaagctgtg atcgtgacat ggcctccagc   2160
 ctgggtgacc gagtgagact gtttctaaaa ataaaaaaaa aa                      2202



      <210> 1405
      <211> 2238
      <212> DNA
      <213> Homo sapiens


      <400> 1405
 tttttttttt ttgatgattt ggatattatt attacaaaga atttaaatat acaagtttgg     60
 ctatgaaaga cccagctaag ccacttaggc aaaagtctat ctttgatgtc atagtttcca    120
 agaagtatca taagagtcaa acagttaaac atttctctgt gctttttttt tctattttct    180
 aggaaatgtt gggtttagag agaagctcat caacttactt atacaaatca ggatatactg    240
 aggggggggg aggataaact cgacatttcc atattttata atataatgtg gaaagattca    300
 gaaatgactg agaagataca gtgatatgat atttaaagca aatattggca tatgcttata    360
 caagaaaggc atcttacaat aatatttctg ttggtacatt acaatttttc agctagtaat    420
 tctaaaatgc cagaggtcct atgatgcaat atcaaaaaaa ccagggaact gacatacaaa    480
 gtcaaatata aagatagtaa cattcagtca tccacagata aaaggctatc tggacataag    540
 cctgaaacaa gcaagacgcc atccactgcg atttcgccgg ttttgccctt gccacgttct    600
 gcttcaaaaa tgatgctttt ggtagcatca gttccttgat acaactgaat tttccctgtc    660
 ttccactttt catcctcact cgtggtcttc tcccatgcca gggcattgtt actgtttttc    720
 acaaacactc gaagtttccc gactttgtct ccggccagcc ggtaatcaaa gagcaaacag    780
 aagttgcttt ggggttgcag gtcaggtagg agaagtttca atcggccaat gtctttcctt    840
 gtgaccctgc caaaggccgg gaactgccaa tatagaagcc aaatagcatt atctccgatc    900
 agcaggattc ccagtcaaaa tcatcttcgt ctatcctgtt tcccagtcac agatccccat    960
 gattgaagct gcagtcaacc gagatattta aatctgcttt atgttccagt ttggaagtta   1020
 gcgctttcct ttggaccgag aatcaggccg aattcacctg cttcattcac cttagggaaa   1080
 aacacatctc cctcgaaaag gtcgctccct cctatgtcaa tccttcaggg ctttctcttc   1140
 tcttttctca tcctcaagcc cctctttcat tttctcttca ttcccttttt taccctccat   1200
 gagagttccc gcctctggaa actatctctt catagttgaa gggctgcaag ttcaccttag   1260
 gggtaggagt cctggtgggt tctggggtaa catttttaat ttttgccttc tttttcatgc   1320
 tgtttttgtg agcaagcaac ttcttgattc tgtctttgat ggtaccaggt gctctgagga   1380
 cttccttcac agaattttca gggatagcag aacaccgaag tccattgcct ttatatccct   1440
 gcttgcattt acacttgaag gacccttggg tattgaagca attggcatgg tggctgcacg   1500
 tatggctatc catagtacat tcatttatat ctatacagtc atatcgtcca ctgatatatt   1560
 gcagttcgaa accaatgtga catttgcagt agtagcttcc aaatgtgttc acacatcttc   1620
 gattgtaggg acagatgact ttaccagagg cacattcatc aatatctaga cagtctcttc   1680
 catttggggc caggcggagt cctgaggatg gacacaggca ctgtggccct tcttctgtgt   1740
 cttcacagct gtactgacag tttatcatgg cacatgtcct agagttcaca cacgtagcat   1800
 ctggcatgag catgtggcca ctgaggcaaa agcacttgta gcttccgtgt gtattcacac   1860
 atctgtgttg gcatggccgg ggtttcattc cacactcatt cacatcttga ctgcaggttt   1920
 tcccggtgta tcctggaaag catctgcatt tgtttggtcc cacgcactca ccaaacttac   1980
 atccaggttc gcatgtagct tcacagactc ccttgctgtt tcttctccag ccgtagcagc   2040
 aggccagttt agttccatag tgacagaccc caggctgacg tgccgatgct aacaacccgt   2100
 gatgccttgc actggccgcg ttcccgaaac cacctgccac ccaggagagc agcagcggga   2160
 gcgcaaggct ccagggcaga ggcattctcg cacgggtcct ccttcctcct cctgagcccc   2220
 cctcgggagg gcgccggc                                                 2238



      <210> 1406
      <211> 469
      <212> DNA
      <213> Homo sapiens


      <400> 1406
 gaaaggaacc aagaatgggc agttcaacta cccttgggat gtggcggtga attctgaggg     60
 caagatcctg gtctcagaca cgaggaacca ccggatccag ctgtttgggc ctgatggtgt    120
 cttcctaaac aagtatggct tcgagggggc tctctggaag cactttgact ccccacgggg    180
 tgtggccttc aaccatgagg gccacttggt ggtcactgac ttcaacaacc accggctcct    240
 ggttattcac cccgactgcc agtcggcacg ctttctgggc tcggagggca caggcaatgg    300
 gcagttcctg cgcccacaag gggtagctgt ggaccaggaa gggcgcatca ttgtggcgga    360
 ttccaggaac catcgggtac agatgtttga atccaacggc agcttcctgt gcaagtttgg    420
 tgctcaaggc agcggctttg ggcagatgga ccgcccttcc ggcatcgcc                469



      <210> 1407
      <211> 4134
      <212> DNA
      <213> Homo sapiens


      <400> 1407
 tttttttttt ttcccgatta aaaacttttt atttcagcaa aataaacgtg cctgtgaaag     60
 aaccacacgg tggcttccga gagaccccac tgtgtacctg agccccaggt ggccacacct    120
 ggtgttctgg aaaagggagt ccagggccag tattcaggcc ctgctgtact gcaccctgga    180
 aactgcacca aaccccagct ccgcccccat ccacggctcc cagaatggtt tctggagtcc    240
 ctgcaacaga cctgtgagga gagggcaggg cagggcctgc ctcctgcgtc cccgtgatga    300
 cctgggggat gcactgggca gggacagctt cctccatcca cacagccctg tgggcaccaa    360
 caaggccact gtgacttcac acgacagcag tgttccccag ctcagctgag ccggggtgca    420
 ggggacagca cagggcacag tcctgtgccg caaggccctc gtgctcctgg aagcctctgg    480
 gaggaggcgc ccgctggtgg gacgtcgaag tccaggcgct ctcggcagcg accccaggac    540
 ggcgcaccta agctatgccg tggtgcaggg gacgtgctgg agggacagga gcaggcgaga    600
 gagaagccac ctgtggtccc agccccaccc cagctcacac gaattccggc tgcctttccc    660
 tgcaggagcc cagcgtcatc cgcccgccac ggagcctcat ggggggcagt ggggcctgca    720
 gcacgttgtt ggactggttg gtgttgaatc ctgagagctg ctgggccggg ccgtcctcgt    780
 ccccgtcccc gtcctcccgg gctgtggcct ccagctgctc ctcactgccg ctgtggctgc    840
 cagaagccac ctctaggctg gcctcgctct gctgctgctc caggaagctg aggtggccca    900
 gggcactggc ctccgatgag gacagcagct cggaggcctc ctctaggtcc gagtccgaat    960
 cgttggacac aactcgggat tctctgcacc cgtccgccgc cgcctcctgc agcgggtaga   1020
 ccaccgcctc gcccgcctcc aggtacggca cctggacgac tacctcagct cgctggttgg   1080
 atgactcgtc ctggcccccg ggggtctcct ccggctcctc ctcgaagacc aggccgtagt   1140
 ggacgatgag agtctcgatg acgcgggcct gatggggata atccaccagg gaggagaggg   1200
 acacggtggc ctcggtgggc cgtggccgaa gcagcgtggg cccgaacacg atgcccaggt   1260
 tcccgggggt catcttgttg tcctgctcca cctccacgat cctgcgtagg tgacgcagca   1320
 ggtactgcag cgaggcccgg ttctcaggcg gcaggtcccg caggagctcc cgcagccgac   1380
 ctgccagggc caccgccact gcctcgctct ccgagccgtc ctgccggccc cgggacgccg   1440
 ccttggcctc ggcctctgcc ttcaggctgt ccttggccag ccctacgagc tcgtggtaga   1500
 ggcggaagga gatgagcggc tcgggaagct gacgcaggta gagcttgagg acgttgctga   1560
 tgtcgtgggg cgaggcctgc gacagctcga ccagctcctt gccgttctcg aaggcctggc   1620
 acagcttctc cacgcgtgtc tttaccccat tgacccggta gatgcccttg gtgcgcagcg   1680
 cccgccgctc gatctcgcag acgcacttct tgacgatgaa gggcacgccg tcgggggcgc   1740
 tgcgggccgc gtggctgaag tcctggccga acagctgcag gcggccttgc agcttcttgt   1800
 gcccgcactg tatggccagc gtctccagac atttcttgtg gcaggccagg cagcactctt   1860
 cacactcagc accctggaag tagacgtagc tgttgcactc gcggcacttg gcgggcgtgc   1920
 ggagcttccc ggagccggtg agtacgggcc gccttggaca gcccctcgtg gcggaacggt   1980
 ccactgggca cggccaccgg cagctcgggg gtcatgccgt tgaggtcagc ctgctcaaag   2040
 gctgaagccc cggctccacc gtctgggtcc accagctcct ccgtggacga catggtacca   2100
 ctggatgacg tccgctcgaa cttcttaaag tcccctgcgc cagggccggg gtccagccca   2160
 ctgtccgagt ctgagatcga gagcggccat gacttgtgaa cctggtgtcc tcgcccggcc   2220
 ctgtggtcct tggcaggtgt gccctcagtg cacccgcctt cttctggggg gctcccggca   2280
 gcctccggcc gcgccacatc actcacgttg aagctgctct tccgggcacg catgacgggg   2340
 gaccaggcgt tggcggagac gtggggctca aagtcgtagt gcacatcggg ctcctggtcc   2400
 cgctgcagct ggcgcacgtg ggaggcgtac tgctggcctg ggtcatacag cttgctgctc   2460
 tcacacagca tctggaagtg cacgggcagc ggcgccgtct gcatatgcat catctggtag   2520
 taggagatcg tggccgactt gatggtttgg tcgctctgcc ggatgacctc ctggatctgc   2580
 cgcagcgccg tcaccttggt atcctccagc tcctgcttct gcgtcttcgc gtcggccacg   2640
 caggtgcggt aggtggccat agcttcctcc gccttgttct tggcctcctc ctccagccgc   2700
 cgccgcttgt ccagggtctt ggtggccgtg ctgcctgctc ccggcgcgct gccagcctgc   2760
 tcctcctccg ccttggccac gaggaagcga gccttgtcgt ggtcctcgca gcgctgcacg   2820
 taaccctgct tggccttgcg caggttggac tccgcctctt gcagcttcct ctgggcacgg   2880
 tgccaggcct ccttgatctc cttcctgcgc ttctcgtgtt caagccgccg cagggtcagg   2940
 ggctgcatga aggtctgggt ctgcaaggtg cccaccgcct gcaccatgct gtggccgaac   3000
 tccaggtcct gctccagggc cagcgagtag atggacagga gcggcatgtg gggctcctgc   3060
 atgacgctct gtctgcagtt gtgagcgatc ttctgcaggc ccttggcaaa ctccatctcc   3120
 agcgtcgtcc gcttctccag gtagctgatg aggtccttca tgtacttggc catgttcttg   3180
 gcatacagca gtgcggcatc cacgcccccc tcacagcgct gtagcagcac gtccacctcc   3240
 tcggcgggca ggcagccggc gtcacagtct tccaggctgg gaggcgtgcc ctcactgccc   3300
 ggtccataca ggctttccat ggactggctc gagtccccag gaggcactgc taggagggtg   3360
 ctgctgtcca cttcacccat gaggaactcg gacactgtgc tactgaaggc cacagcaatc   3420
 gtctccaggg ccttctcgaa ctcctgtttc tccagatcat tgttgctctc ataatggaag   3480
 gctttgacct tggcaatgag ggtgccggct gcggtgagcg tctccacggt gttcagcagc   3540
 gggtacttgg agatgatctg atgcatgaca cgcagagcct cacccaggca ctcgtgggcc   3600
 cgcgggcggc gggcctcaag gaggtcgtca tgcagcacac actccttaag tttctcaagg   3660
 ccctcagcga agcgggccac gtccgccagc agatgggaga tgtcctcgac gacgtccggg   3720
 ccggcaccct cggtgggcag ctcgcccggg ctggcggctg tcagtgggct ccggtggctc   3780
 cggcccagtg tccaggaggc agcacccgac agggggaagc cagccgcgct ggcgtggcgg   3840
 ctcaggctgg tgggccgctt gagggtccct gtggccttga cgccggagga cccagcgggc   3900
 ggctccaggc ttggtccggg gaacaccgcg tcagccccat ccttcctggg cagctccccc   3960
 gagggctgcg ggctggggct tcccgcgcgg ttctttttcg agatggaagg ggttttcatg   4020
 agctctcgtt tcttcctgga gaacatgatg gggccccggc cgggagcccg agggggcggg   4080
 ctgggggtct cagcgctgca gctcccggcg ctggccgctt cgggaccaca ttgt         4134



      <210> 1408
      <211> 628
      <212> DNA
      <213> Homo sapiens


      <400> 1408
 tgagtgttgg tgcactggac acttttattg ctgcagtata tgagcatgcg gtgatattac     60
 caaacagagc agaaacacct gtttcaaaag aagaagcttt gctcctgatg aacaagaaca    120
 tagatgtttt ggagaaagca gttaagctgg cagcgaagca gggtgcacat atcattgtga    180
 ccccagaaga tggaatctat ggttggatct tcaccaggga gagcatttac ccctatctag    240
 aggatatacc agaccctgga gtgaactgga ttccatgtag agacccctgg agaaatcact    300
 aaaatatagt aagtttgagg aaatgtctat tgaattagat tcggcaacac accagtgcaa    360
 caaagactca gctgcctggc caaggacaac tctatctatg tcgtggctaa tattggggac    420
 aagaagccat gcaatgctag tgactctcag tgtccccctg atggccgtta ccaatacaac    480
 actgatgtgg tgtttgattc tcagggaaaa ctgttggcac gctaccataa gtacaatctt    540
 tttgcacctg aaattcagtt tgatttcccc aaggattcag aacttgtgac ttttgacact    600
 ccctttggga agattggcat tattactt                                       628



      <210> 1409
      <211> 1457
      <212> DNA
      <213> Homo sapiens


      <400> 1409
 taggaattgc ttaaaaacaa gaagttctcc cacccttgtt ggagcgaatg cgcgagtctg     60
 acagtgaacc ttttgggaaa gagccagcat tgtaaccgtg ctcggtgact tctctggctt    120
 tatagggaac agatgtgagg atagcaaggg gcgcacacgt gaaatgcctg gcaggtaccc    180
 ctttgtggct ctacttactt cttgccattc ctctgccctc caagtgtaga ggggacaccg    240
 tgggccttgg cagtcgcgtt ccgactccgg tctggtgtat gggttgcact cggtctctct    300
 ggctattttg tgtgttccga tctgacagcc cacatgcctc tgctgtacgc ctcggccaca    360
 ggacacagag cactaagaag acagagaaca ttcacagtct ggtgagacaa gtttgagatc    420
 tcatattttc agctcatcct tgaaaacctt tcttcgattt gactgacctt gatggctccc    480
 tggaatctca cctacatttt atgggaaatt caactctcca gagagaagag ctttcagata    540
 gctgcgggac ttgcaactgt gactttcagc tttcgctttt gaatgaggct ccaaatgtct    600
 caatggtggc actatttcca gatttgggag ccctgcaaag ctaatctgct caaccttcac    660
 ctactgggtt caatgaatat gaaaagctgc cttcctgaaa cttttccttc aaagagggaa    720
 tgatctcctg gaattcaagc ttctacaagg tggctacctg gtgttttcca cttttgccgt    780
 ctcctaaaaa gcatcaatca agccttgccc tttcaaccca ctgaacacat aaacatgctt    840
 tctccttaac tgaacttatg gccacgatga acttgaactc tgagattcac agaggagagt    900
 ttgttttaac agctgctttt acaatgaagc cctggagtta ctactctcaa gacccctggt    960
 tctgataggc catcttttca ctgtcctctg cattttctaa tgcccagctg tcaaggaaca   1020
 cccactgaag ttttccaaaa caaaggcacg aaacacaaga aaggcaagag aatgctaatc   1080
 accagatgca tgggcatcct atgggggaac cccttacatg tggaatacgg tttttctccc   1140
 caatttattt ttataaattt attgatttct ttgctagttt gttattaatt gttagagatg   1200
 tcctgttgcc tgaggttgcc ctgtccgata tggtagccac cagcgacagg tagctattta   1260
 gagtaattta aaaattacat taaaaatgca gtttccttgt cacttaacca tgtttcaagt   1320
 gctcagtatt aaccacatgt gactagtggc ttccataaag gaaggcaaaa atagagaaca   1380
 tttacatcgc tgcagaaagc tactagattt ttttggccaa ggcataagct ctttctcata   1440
 agagaaaggg gattgca                                                  1457



      <210> 1410
      <211> 2679
      <212> DNA
      <213> Homo sapiens


      <400> 1410
 cttccatgac agcatcaccc tcattgttct gtcatctgag gtgggcatct ctgagctgag     60
 gctggagaga ctactccaaa tggtgtttgg agccatggtc cttcttgtgg gacttgaaga    120
 actgaccaat atccgcaacg tggagagact gaagaaggac ttgagggcca gttattgcct    180
 catcgacagc ttcctggggg actcggagct catcggggac ctgacccagt gtgtggactg    240
 cgtgattcct ccagaggggt ccctcttgca ggaagccctc tccgggttcg ctgaggccgc    300
 gggcacgacc ttcgtcagtc tggtggtgtc cggccgggtg gtggcagcaa cagagggttg    360
 gtggcggctg gggacgcccg aggccgtgct gctcccctgg ctggtggggt ccctgccgcc    420
 gcagaccgct cgcgactacc cggtgtacct gccgcacggg agccccacgg tcccacaccg    480
 gctcctgacc ctgactctgc tgccgagcct ggagctgtgt ctactctgcg ggccgagccc    540
 acccctcagc cagttgtatc cacagcttct ggagcgctgg tggcagccac tgctggaccc    600
 gttgcgggcc tgtctgccgt tgggaccccg ggcgctgccc agtggcttcc cccttcacac    660
 agacatcctc gggctgctgc tcctccacct ggaactgaag cgctgcctct tcaccgtgga    720
 gcccttgggg gataaagagc cttcaccaga acagcgccgg cgcctcctcc gaaacttcta    780
 taccctggtc acctccacgc acttcccacc agagccaggg ccaccagaga agacagaaga    840
 tgaggtctac caggcccagc tgcccagagc ttgctacctg gtgttgggga ctgaggaacc    900
 aggcacagga gtgcgtctgg tggccttgca gctggggctt cggcggctgc tgctgctgct    960
 gtctccccag agtcccaccc atgggctgcg aagcctggcc acccacactc tgcatgccct   1020
 caccccactt ctttgactac ctagcagtgg gtgatggaca cagacatggg gctgttagcg   1080
 tctctctgtt tattcgctca caataataca cagcccctgg atggggaggg gggtaggagg   1140
 ggctacaaca agggtggggt gggaggggat ggagacatcc acttccctgg cccctctccc   1200
 ctctgtgctt gggggggaaa gggagggagg gggacttccc ctaacccccc agaatgtaaa   1260
 cagcagcaga tgaacaaaaa aaaaaataca aaaggccgga ggaaagtccc aggcatcccc   1320
 caaaccctgg tgtcttctct gtcaccagtg gaggtccccc atccaccaaa actgcctcag   1380
 tccaaggggc tgcccagtgc cggccacatc ccccggggca gagtccaggg ctcagaactg   1440
 ctgtgccagc agctcacaca ggtgacggga gacgggctcc ttgctggtgc gcagggtcag   1500
 ccggtacatc tgggcctggg cattgggctc cagccgaagc agacagccca cctgcagggc   1560
 tttagtctgg atgatccccg cccccacgaa gttctcaggg ttggggtcca cattgtccag   1620
 gagagcagag ccaaacccca gaagcttggc cttagtaact tctgcgtcca tggggtggtt   1680
 ggctttgaag attttctgcg cctcctgttg agggaggctc agctgcttcc agcgctggaa   1740
 gaaatcctgg gccgccatct cggtgggctg gaagaacttg ttgatggtca ctgggagctt   1800
 cagggtgagg gcctgggggg cgccaccgta ccggaagcgc acggacagca gcgggggcgt   1860
 caggaagtcc cgcaggcact cgatattgag cacctgctgc acctgcgcgc cgccgtccac   1920
 ctgcgccgcc acgcgcttgg tctgcacagc cagctgagtc tggaggtctc ccgggtgaac   1980
 cacagtgggt gagaaattct ggaactgcac cgaggtcttg ttgccataga agagatacat   2040
 gcggcccagg ttctgtcgga actctgactt gactccgatc tgcagcagct ggttctcgaa   2100
 caggaccccg ttgttcttac acacaaactt attcagcaac tcatcggctt ccggaatggg   2160
 agggccgatg tcctcaggac ctgggctgag gaaggcctcc tcgggggtgg gccccaggct   2220
 gggctgggcg gccgggccat cgaagacgtc caccagaagg ttccctgctc ctgcagaagc   2280
 cgggggtgct gccgggggag gggctgcccg cagccccagg aggtcggcgg agggcgaggg   2340
 cgtcgacaca gtgctggggg tgggctccat gcccccgttg atgtcgttgc tgctggggtc   2400
 cctccggcca tcgtccaggg cgctgccggc ccctggcccc ttcttgcgtt tcagcttggc   2460
 caggatggac gactcgcgct cggggaaggg cggcatctcc tccagcaccg tggccaggac   2520
 gtcggtgctg gccactgagc tgagggtgag gtactccacg gctcgctgct gcagctccac   2580
 gtcagcattg cgcagctggg agccggcccg caggacgccc tggatggtgg ccttggtctc   2640
 ggggaagagg ttgatgaact tgatgtaggt ggacagcag                          2679



      <210> 1411
      <211> 2280
      <212> DNA
      <213> Homo sapiens


      <400> 1411
 aggggattcg gcagctcctt ttcagctcgc tcggagcacc cacgcctcgc tgccccgctt     60
 gctgccctca acctgggcat gcgcccccca cccttccggc cccccagaac ccgcgccatc    120
 ccccggagcc tccccagagc tggccgcgca ggatgggcgc cctcaggccc acgctgctgc    180
 cgccttcgct gccgctgctg ctgctgctaa tgctaggaat gggatgctgg gcccgggagg    240
 tgctggtccc cgaggggccc ttgtaccgcg tggctggcac agctgtctcc atctcctgca    300
 atgtgaccgg ctatgagggc cctgcccagc agaacttcga gtggttcctg tataggcccg    360
 aggccccaga tactgcactg ggcattgtca gtaccaagga tacccagttc tcctatgctg    420
 tcttcaagtc ccgagtggtg gcgggtgagg tgcaggtgca gcgcctacaa ggtgatgccg    480
 tggtgctcaa gattgcccgc ctgcaggccc aggatgccgg catttatgag tgccacaccc    540
 cctccactga tacccgctac ctgggcagct acagcggcaa ggtggagctg agagttcttc    600
 cagatgtcct ccaggtgtct gctgcccccc cagggccccg aggccgccag gccccaacct    660
 cacccccacg catgacggtg catgaggggc aggagctggc actgggctgc ctggcgagga    720
 caagcacaca gaagcacaca cacctggcag tgtcctttgg gcgatctgtg cccgaggcac    780
 cagttgggcg gtcaactctg caggaagtgg tgggaatccg gtcagacttg gccgtggagg    840
 ctggagctcc ctatgctgag cgattggctg caggggagct tcgtctgggc aaggaaggga    900
 ccgatcggta ccgcatggta gtagggggtg cccaggcagg ggacgcaggc acctaccact    960
 gcactgccgc tgagtggatt caggatcctg atggcagctg ggcccagatt gcagagaaaa   1020
 gggccgtcct ggcccacgtg gatgtgcaga cgctgtccag ccagctggca gtgacagtgg   1080
 ggcctggtga acgtcggatc ggcccagggg agcccttgga actgctgtgc aatgtgtcag   1140
 gggcacttcc cccagcaggc cgtcatgctg catactctgt aggttgggag atggcacctg   1200
 cgggggcacc tgggcccggc cgcctggtag cccagctgga cacagagggt gtgggcagcc   1260
 tgggccctgg ctatgagggc cgacacattg ccatggagaa ggtggcatcc agaacatacc   1320
 ggctacggct agaggctgcc aggcctggtg atgcgggcac ctaccgctgc ctcgccaaag   1380
 cctatgttcg agggtctggg acccggcttc gtgaagcagc cagtgcccgt tcccggcctc   1440
 tccctgtaca tgtgcgggag gaaggtgtgg tgctggaggc tgtggcatgg ctagcaggag   1500
 gcacagtgta ccgcggggag actgcctccc tgctgtgcaa catctctgtg cggggtggcc   1560
 ccccaggact gcggctggcc gccagctggt gggtggagcg accagaggat ggagagctca   1620
 gctctgtccc tgcccagctg gtgggtggcg taggccagga tggtgtggca gagctgggag   1680
 tccggcctgg aggaggccct gtcagcgtag agctggtggg gccccgaagc catcggctga   1740
 gactacacag cttggggccc gaggatgaag gcgtgtacca ctgtgccccc agcgcctggg   1800
 tgcagcatgc cgactacagc tggtaccagg cgggcagtgc ccgctcaggg cctgttacag   1860
 tctaccccta catgcatgcc ctggacaccc tatttgtgcc tctgctggtg ggtacagggg   1920
 tggccctagt cactggtgcc actgtccttg gtaccatcac ttgctgcttc atgaagaggc   1980
 ttcgaaaacg gtgatccctt actccccagg tcttgcaggt gtcgactgtc ttccggccca   2040
 gctccaagcc ctcctctggt tgcctggaca ccctctccct ctgtccactc ttcctttaat   2100
 ttatttgacc tcccactacc cagaatggga gacgtgcctc cccttcccca ctccttccct   2160
 cccaagcccc tccctctggc cttctgttct tgatctctta gggatcctat agggaggcca   2220
 tttcctgtcc tggaattagt ttttctaaaa tgtgaataaa cttgttttat aaaaaaaaaa   2280



      <210> 1412
      <211> 2280
      <212> DNA
      <213> Homo sapiens


      <400> 1412
 aggggattcg gcagctcctt ttcagctcgc tcggagcacc cacgcctcgc tgccccgctt     60
 gctgccctca acctgggcat gcgcccccca cccttccggc cccccagaac ccgcgccatc    120
 ccccggagcc tccccagagc tggccgcgca ggatgggcgc cctcaggccc acgctgctgc    180
 cgccttcgct gccgctgctg ctgctgctaa tgctaggaat gggatgctgg gcccgggagg    240
 tgctggtccc cgaggggccc ttgtaccgcg tggctggcac agctgtctcc atctcctgca    300
 atgtgaccgg ctatgagggc cctgcccagc agaacttcga gtggttcctg tataggcccg    360
 aggccccaga tactgcactg ggcattgtca gtaccaagga tacccagttc tcctatgctg    420
 tcttcaagtc ccgagtggtg gcgggtgagg tgcaggtgca gcgcctacaa ggtgatgccg    480
 tggtgctcaa gattgcccgc ctgcaggccc aggatgccgg catttatgag tgccacaccc    540
 cctccactga tacccgctac ctgggcagct acagcggcaa ggtggagctg agagttcttc    600
 cagatgtcct ccaggtgtct gctgcccccc cagggccccg aggccgccag gccccaacct    660
 cacccccacg catgacggtg catgaggggc aggagctggc actgggctgc ctggcgagga    720
 caagcacaca gaagcacaca cacctggcag tgtcctttgg gcgatctgtg cccgaggcac    780
 cagttgggcg gtcaactctg caggaagtgg tgggaatccg gtcagacttg gccgtggagg    840
 ctggagctcc ctatgctgag cgattggctg caggggagct tcgtctgggc aaggaaggga    900
 ccgatcggta ccgcatggta gtagggggtg cccaggcagg ggacgcaggc acctaccact    960
 gcactgccgc tgagtggatt caggatcctg atggcagctg ggcccagatt gcagagaaaa   1020
 gggccgtcct ggcccacgtg gatgtgcaga cgctgtccag ccagctggca gtgacagtgg   1080
 ggcctggtga acgtcggatc ggcccagggg agcccttgga actgctgtgc aatgtgtcag   1140
 gggcacttcc cccagcaggc cgtcatgctg catactctgt aggttgggag atggcacctg   1200
 cgggggcacc tgggcccggc cgcctggtag cccagctgga cacagagggt gtgggcagcc   1260
 tgggccctgg ctatgagggc cgacacattg ccatggagaa ggtggcatcc agaacatacc   1320
 ggctacggct agaggctgcc aggcctggtg atgcgggcac ctaccgctgc ctcgccaaag   1380
 cctatgttcg agggtctggg acccggcttc gtgaagcagc cagtgcccgt tcccggcctc   1440
 tccctgtaca tgtgcgggag gaaggtgtgg tgctggaggc tgtggcatgg ctagcaggag   1500
 gcacagtgta ccgcggggag actgcctccc tgctgtgcaa catctctgtg cggggtggcc   1560
 ccccaggact gcggctggcc gccagctggt gggtggagcg accagaggat ggagagctca   1620
 gctctgtccc tgcccagctg gtgggtggcg taggccagga tggtgtggca gagctgggag   1680
 tccggcctgg aggaggccct gtcagcgtag agctggtggg gccccgaagc catcggctga   1740
 gactacacag cttggggccc gaggatgaag gcgtgtacca ctgtgccccc agcgcctggg   1800
 tgcagcatgc cgactacagc tggtaccagg cgggcagtgc ccgctcaggg cctgttacag   1860
 tctaccccta catgcatgcc ctggacaccc tatttgtgcc tctgctggtg ggtacagggg   1920
 tggccctagt cactggtgcc actgtccttg gtaccatcac ttgctgcttc atgaagaggc   1980
 ttcgaaaacg gtgatccctt actccccagg tcttgcaggt gtcgactgtc ttccggccca   2040
 gctccaagcc ctcctctggt tgcctggaca ccctctccct ctgtccactc ttcctttaat   2100
 ttatttgacc tcccactacc cagaatggga gacgtgcctc cccttcccca ctccttccct   2160
 cccaagcccc tccctctggc cttctgttct tgatctctta gggatcctat agggaggcca   2220
 tttcctgtcc tggaattagt ttttctaaaa tgtgaataaa cttgttttat aaaaaaaaaa   2280



      <210> 1413
      <211> 2280
      <212> DNA
      <213> Homo sapiens


      <400> 1413
 aggggattcg gcagctcctt ttcagctcgc tcggagcacc cacgcctcgc tgccccgctt     60
 gctgccctca acctgggcat gcgcccccca cccttccggc cccccagaac ccgcgccatc    120
 ccccggagcc tccccagagc tggccgcgca ggatgggcgc cctcaggccc acgctgctgc    180
 cgccttcgct gccgctgctg ctgctgctaa tgctaggaat gggatgctgg gcccgggagg    240
 tgctggtccc cgaggggccc ttgtaccgcg tggctggcac agctgtctcc atctcctgca    300
 atgtgaccgg ctatgagggc cctgcccagc agaacttcga gtggttcctg tataggcccg    360
 aggccccaga tactgcactg ggcattgtca gtaccaagga tacccagttc tcctatgctg    420
 tcttcaagtc ccgagtggtg gcgggtgagg tgcaggtgca gcgcctacaa ggtgatgccg    480
 tggtgctcaa gattgcccgc ctgcaggccc aggatgccgg catttatgag tgccacaccc    540
 cctccactga tacccgctac ctgggcagct acagcggcaa ggtggagctg agagttcttc    600
 cagatgtcct ccaggtgtct gctgcccccc cagggccccg aggccgccag gccccaacct    660
 cacccccacg catgacggtg catgaggggc aggagctggc actgggctgc ctggcgagga    720
 caagcacaca gaagcacaca cacctggcag tgtcctttgg gcgatctgtg cccgaggcac    780
 cagttgggcg gtcaactctg caggaagtgg tgggaatccg gtcagacttg gccgtggagg    840
 ctggagctcc ctatgctgag cgattggctg caggggagct tcgtctgggc aaggaaggga    900
 ccgatcggta ccgcatggta gtagggggtg cccaggcagg ggacgcaggc acctaccact    960
 gcactgccgc tgagtggatt caggatcctg atggcagctg ggcccagatt gcagagaaaa   1020
 gggccgtcct ggcccacgtg gatgtgcaga cgctgtccag ccagctggca gtgacagtgg   1080
 ggcctggtga acgtcggatc ggcccagggg agcccttgga actgctgtgc aatgtgtcag   1140
 gggcacttcc cccagcaggc cgtcatgctg catactctgt aggttgggag atggcacctg   1200
 cgggggcacc tgggcccggc cgcctggtag cccagctgga cacagagggt gtgggcagcc   1260
 tgggccctgg ctatgagggc cgacacattg ccatggagaa ggtggcatcc agaacatacc   1320
 ggctacggct agaggctgcc aggcctggtg atgcgggcac ctaccgctgc ctcgccaaag   1380
 cctatgttcg agggtctggg acccggcttc gtgaagcagc cagtgcccgt tcccggcctc   1440
 tccctgtaca tgtgcgggag gaaggtgtgg tgctggaggc tgtggcatgg ctagcaggag   1500
 gcacagtgta ccgcggggag actgcctccc tgctgtgcaa catctctgtg cggggtggcc   1560
 ccccaggact gcggctggcc gccagctggt gggtggagcg accagaggat ggagagctca   1620
 gctctgtccc tgcccagctg gtgggtggcg taggccagga tggtgtggca gagctgggag   1680
 tccggcctgg aggaggccct gtcagcgtag agctggtggg gccccgaagc catcggctga   1740
 gactacacag cttggggccc gaggatgaag gcgtgtacca ctgtgccccc agcgcctggg   1800
 tgcagcatgc cgactacagc tggtaccagg cgggcagtgc ccgctcaggg cctgttacag   1860
 tctaccccta catgcatgcc ctggacaccc tatttgtgcc tctgctggtg ggtacagggg   1920
 tggccctagt cactggtgcc actgtccttg gtaccatcac ttgctgcttc atgaagaggc   1980
 ttcgaaaacg gtgatccctt actccccagg tcttgcaggt gtcgactgtc ttccggccca   2040
 gctccaagcc ctcctctggt tgcctggaca ccctctccct ctgtccactc ttcctttaat   2100
 ttatttgacc tcccactacc cagaatggga gacgtgcctc cccttcccca ctccttccct   2160
 cccaagcccc tccctctggc cttctgttct tgatctctta gggatcctat agggaggcca   2220
 tttcctgtcc tggaattagt ttttctaaaa tgtgaataaa cttgttttat aaaaaaaaaa   2280



      <210> 1414
      <211> 2280
      <212> DNA
      <213> Homo sapiens


      <400> 1414
 aggggattcg gcagctcctt ttcagctcgc tcggagcacc cacgcctcgc tgccccgctt     60
 gctgccctca acctgggcat gcgcccccca cccttccggc cccccagaac ccgcgccatc    120
 ccccggagcc tccccagagc tggccgcgca ggatgggcgc cctcaggccc acgctgctgc    180
 cgccttcgct gccgctgctg ctgctgctaa tgctaggaat gggatgctgg gcccgggagg    240
 tgctggtccc cgaggggccc ttgtaccgcg tggctggcac agctgtctcc atctcctgca    300
 atgtgaccgg ctatgagggc cctgcccagc agaacttcga gtggttcctg tataggcccg    360
 aggccccaga tactgcactg ggcattgtca gtaccaagga tacccagttc tcctatgctg    420
 tcttcaagtc ccgagtggtg gcgggtgagg tgcaggtgca gcgcctacaa ggtgatgccg    480
 tggtgctcaa gattgcccgc ctgcaggccc aggatgccgg catttatgag tgccacaccc    540
 cctccactga tacccgctac ctgggcagct acagcggcaa ggtggagctg agagttcttc    600
 cagatgtcct ccaggtgtct gctgcccccc cagggccccg aggccgccag gccccaacct    660
 cacccccacg catgacggtg catgaggggc aggagctggc actgggctgc ctggcgagga    720
 caagcacaca gaagcacaca cacctggcag tgtcctttgg gcgatctgtg cccgaggcac    780
 cagttgggcg gtcaactctg caggaagtgg tgggaatccg gtcagacttg gccgtggagg    840
 ctggagctcc ctatgctgag cgattggctg caggggagct tcgtctgggc aaggaaggga    900
 ccgatcggta ccgcatggta gtagggggtg cccaggcagg ggacgcaggc acctaccact    960
 gcactgccgc tgagtggatt caggatcctg atggcagctg ggcccagatt gcagagaaaa   1020
 gggccgtcct ggcccacgtg gatgtgcaga cgctgtccag ccagctggca gtgacagtgg   1080
 ggcctggtga acgtcggatc ggcccagggg agcccttgga actgctgtgc aatgtgtcag   1140
 gggcacttcc cccagcaggc cgtcatgctg catactctgt aggttgggag atggcacctg   1200
 cgggggcacc tgggcccggc cgcctggtag cccagctgga cacagagggt gtgggcagcc   1260
 tgggccctgg ctatgagggc cgacacattg ccatggagaa ggtggcatcc agaacatacc   1320
 ggctacggct agaggctgcc aggcctggtg atgcgggcac ctaccgctgc ctcgccaaag   1380
 cctatgttcg agggtctggg acccggcttc gtgaagcagc cagtgcccgt tcccggcctc   1440
 tccctgtaca tgtgcgggag gaaggtgtgg tgctggaggc tgtggcatgg ctagcaggag   1500
 gcacagtgta ccgcggggag actgcctccc tgctgtgcaa catctctgtg cggggtggcc   1560
 ccccaggact gcggctggcc gccagctggt gggtggagcg accagaggat ggagagctca   1620
 gctctgtccc tgcccagctg gtgggtggcg taggccagga tggtgtggca gagctgggag   1680
 tccggcctgg aggaggccct gtcagcgtag agctggtggg gccccgaagc catcggctga   1740
 gactacacag cttggggccc gaggatgaag gcgtgtacca ctgtgccccc agcgcctggg   1800
 tgcagcatgc cgactacagc tggtaccagg cgggcagtgc ccgctcaggg cctgttacag   1860
 tctaccccta catgcatgcc ctggacaccc tatttgtgcc tctgctggtg ggtacagggg   1920
 tggccctagt cactggtgcc actgtccttg gtaccatcac ttgctgcttc atgaagaggc   1980
 ttcgaaaacg gtgatccctt actccccagg tcttgcaggt gtcgactgtc ttccggccca   2040
 gctccaagcc ctcctctggt tgcctggaca ccctctccct ctgtccactc ttcctttaat   2100
 ttatttgacc tcccactacc cagaatggga gacgtgcctc cccttcccca ctccttccct   2160
 cccaagcccc tccctctggc cttctgttct tgatctctta gggatcctat agggaggcca   2220
 tttcctgtcc tggaattagt ttttctaaaa tgtgaataaa cttgttttat aaaaaaaaaa   2280



      <210> 1415
      <211> 1304
      <212> DNA
      <213> Homo sapiens


      <400> 1415
 tattcagtga ttgtctagag agggctacta agattgtacc ttctaaactg tattgtcttt     60
 ccttattcgt atgagttggc atggcttctt ttatcactaa ttccttttct ggaaaggggt    120
 aaaaatagtt atgacagttt tgggaaggtg cgttttcaga ttagctgttt ccagagctga    180
 aggtaatcat ttattcaagg cctgatgagc tggagtttgc agcaggagta ggagttaatg    240
 aagtattgat acttggtaac cctttttgta aaaaaaaaaa attttaattt tttttttata    300
 gagacagggg tctccctatg ttgcccaggc tggcctcgga actcctgggc tcaagggatc    360
 ctcccacctt ggcctcccaa agtgctggga ttacaggcag ccatgcccag ccagggcaga    420
 catttttatg cacaactttc tgtggggctc aagtgcacct atgatacata aattttacag    480
 ttcttgatcc ccaaacagag caggaggcag ggtgcctggg gccagggttc ctttggggaa    540
 atgtggtcct tgaggtagag tcacagatgc cggagggtga ccagcactac tgggggagag    600
 atctcctctg gggagagatg catgccaaag gtccctcttg cattcctcat acctcttgat    660
 gcggacagag gggtgtccag ctgaatgatg tggggccccc gcatcctctg cagctgggcc    720
 cgagtcagct tccgtggcct gctgtcccgg ggctcctcgg ccccctcaat cctttggctg    780
 gccagctcct cccggatctc tctgagcatg tcctcagccc gcattgggcg cagggatgtg    840
 tggccagctt tcaggaacag aggcccctct tcttcctcct cccctgagga ctcccagggg    900
 ctttccccgg cagagtcagc atgggttggg gaggagggaa gctggccccg aagccgggcc    960
 ctgtggagtg tttccaccac cacattccct cgctcggagg ccccatcttc ttcctcagac   1020
 caggttggtg ggtcttcctg gggaagactg cctcctttta ggattccttc cggcagttcg   1080
 ggggcgcttc ggcgttgagg agcttggggg tcgggagggt ggggacgcag agggatgtcc   1140
 cggagttcca gggtggagaa ggtgaggcga gggtcccgcc gaagggctct ttggcgtaga   1200
 cggctcagtg gggagcggga ccccgtgggg gtgcctggga tcaaagtgcc gtagccagag   1260
 tctgaggtat catctggcac aaggggagca tcttcatctg tgtc                    1304



      <210> 1416
      <211> 1595
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1595)
      <223> n = a,t,c or g


      <400> 1416
 tttttttttt ttctttaaaa ccatttactt acaaacttta attcagcaaa ggtccgtgtg     60
 gggagactgg ggtggggtcg ggggaatagt ccccttggag tggatgtgga cccccagagt    120
 caagggaggg aagctggtgg cccagttggc tgggggcaag gcccagggtc acctcaggtc    180
 gacaggtcct gctggtgggc gggcccagag tttatcttca tggagtgctg gtttctggca    240
 ctgggctgga aggaggccag ctccagggat ctggccgggg gtgggcaggc agaattcaag    300
 aattcatctt caacaagcga gtgacagcag aggctccggg agatgggcac aatgtccgac    360
 tcccacagac agacagcagg ggactggcag agaaagccca tctctgcacg gaggcccggg    420
 taggaggggg tggtggggcc ggttcgccaa gatgaaggct ttccccttct actgtcccca    480
 gggtggagat cctgggtagg gtggcccaat ccctaggcca gagctgtttg gtccatagtc    540
 aagctcccag agcttggcat ctgtggctct ggccagcagg gcctggggcc cagcttttaa    600
 ggcatcagaa ggggaggggg ctgcggcagg gaccccgggc cccacggctg gggtataggc    660
 cagatgggca ggcaggggca ggagacagcc atgcctgcag caaatgtggg aaaaacagct    720
 gtttcaaacc gcaaggtgtg gaatggtggc ccggacaggc cgggccttga aggaatcaga    780
 gctgggggct gtccggggtg gtttgaaaaa taaaacttag aaaaggaaac agaagtcagt    840
 tgtcaaagtt aaaaaaaaaa ggagacagtc tctgtatctt cacgggaggt cagggaaacc    900
 tccaaggcac tcgaaaggcc aaaattacag gagcaatgag gcaggagggc tccggagaga    960
 cgggcacagc ggaggaggag atggggggag ggagggagag caggccgggg cccctctctc   1020
 ttaaggctgc agggtttcag cgtggggagc aagccagaga cataatgagg cctccagact   1080
 cccccacacc ccttgggctc ctggggctcc ggctgattgg tcagtaaagt ctttcagaga   1140
 tttttctatt accgaaagag agaaaatggt ttaaaaaaaa cacaaaacaa aacatcagaa   1200
 aacccaaaag cgatttggtg caggcccttg agttatctct ggtgccagcc acttagaaaa   1260
 tcctcttccg cttcaggtag gagtccgcgt agtggccgcc gaggccctgg gagtgctggc   1320
 ccacatagct gccttctggg ctgggctcgg gcgagggcag caggtgggca aagctgcgtt   1380
 tctgcccgcc cagtggggtc ttcagcaggt ggctgtgacc attaggcccg ggggtgaggc   1440
 ccaggagccc ttccccggac cccagcgggg aagagccgat tgccttactg aggtggctct   1500
 gcttgaggcc agcctgcagg ccgctggtaa gtattcctgn nnnncgtnnt tcgagactgc   1560
 agtncgggcc ccctgggtta ttcctnncgg gcccc                              1595



      <210> 1417
      <211> 871
      <212> DNA
      <213> Homo sapiens


      <400> 1417
 tttttttttt ttccggcact aagtcaagtt ctttacttcc cagaagtgat ggctaagggg     60
 agggaggagg gtgagaagag gaagacagaa agagccagag agaatgagga ggtgagaagg    120
 gggggacagt aaaccactgt tctatgaagt ctcacgaggc aagtgctcaa ggtaaaaaaa    180
 gagtcctgga gaatcgtcca cggctgcggg aagcatctcg gtttccttct gcttttaagt    240
 cctctcaggg aaggctgtcg ccgctgccgc tgcattaaat agttatgtac atcgcagaga    300
 gtcccaggcc atgggcaggt gggggagggg cgtcatttca ccaggggccg agttttatca    360
 tcgtcaccgc actggtgagc tttgtacttt ttcacttctg ccatgtactt ggcccacgcg    420
 tcacctttac ttgttaatac ctcatcctcc gtcttctgct tcttggctac tattcccgtc    480
 ttgagggcta gtttgttccc gcctctgcgt ttgcccacga agctaagtgt ggagcccgga    540
 ccgcccttcc tcttcggatc cccggggcca gcggcggcgg ccgactggtc gggtcgctgc    600
 ggacccgggg gcggctcctc ctgccgctgc cgctgctcct cctccatctt ccgcttgaac    660
 agctccagga agctgccgtc gttggcgaac aagttcacgc cgcccgacac cgggctcgaa    720
 cccgcgcccg acacctcctc gtccccgctc tcgggcgacg tccccgatcc cgactcagcc    780
 caacggctcc cgccaccgcc accgcccgcg gggcccggag cctcccggcc ctgaggctcc    840
 gcccgtctcc ctcgggcagc cattttgtcg c                                   871



      <210> 1418
      <211> 1141
      <212> DNA
      <213> Homo sapiens


      <400> 1418
 atagaaaacc tgatgaccct tagaccgtgc ggtggaattc gcggtcgggt ccgggcgccc     60
 gcgcagaatc agctgtctga gctgcccagg cggcggggga gcagcgagcg ggcttcagcg    120
 agccgcagga ggcacaggcc tgtcctgggt ccccgcaggt ctgcgcgtct gttgttccca    180
 gcgctctgag aggcctgaaa aggaagagca acctgtccag aatccccgca ggaaaggaaa    240
 aggaggggaa atctcgacat ggaaaaactc ttcaatgaaa atgaaggaat gccttcgaat    300
 caaggaaaga tagacaatga agaacagcca ccgcacgagg gaaagccaga agtagcttgt    360
 attctggaag acaagaagtt agaaaacgag ggaaacacag aaaacacggg caagagagtt    420
 gaggaaccgt taaaggataa agaaaagcca gagagtgcgg gaaaggcaaa aggagaagga    480
 aagtcagaga ggaagggaaa gtcagagatg cagggaggat caaagacaga gggaaagcca    540
 gagagagggg gaagggcaga gggtgaagga gagccagaca tgggtaagag agccagagag    600
 tgagggagag ccagaaagtg aaacaagggc tgcaggaaag cgcccagctg aggatgatat    660
 acccaggaaa gccaaaagaa aaaccaacaa ggggctggct cagtacctca agcaatataa    720
 ggaagccata catgatatga atttcagcaa tgaggacatg ataagagaat ttgacaacat    780
 ggctagggtg gaggataaaa ggagaaaaag caaacagaaa ttgggggcgt ttttgtggat    840
 gcaaagaaat ttacaggacc ccttctatcc taggggtcca agggaattca ggggtggctg    900
 cagggcccca cgaagggaca ctgaagacat tccttatgtg tagtgtccct ggcaggcatt    960
 tgtcaggcca tatgttttaa ccttatggta atactttgct ttagtcgttc ctcctgctac   1020
 cagtagcgtt ttgacccacc tgccagtgtt tgcttgctct atgtttcagt agcagatttt   1080
 cacacatgtg cattgcagag acgtcatgat tcgtggaaaa ataaagcagc ttataatatc   1140
 a                                                                   1141



      <210> 1419
      <211> 554
      <212> DNA
      <213> Homo sapiens


      <400> 1419
 aagagttgaa aggcactgca aaaaaacttg gggagaagct ggctgttgcc aaagacagaa     60
 tgatgctgca ggagtgtcgt gggacacagc agacagatgc catgaagact gagttagttt    120
 cagagaacaa agtcctgcgg gaagagaatg acttggaagc cggcaatctt catcctcagc    180
 aggatcaaag ctgtctcaag gagtgccctt gcatgaaagg aggcacagat atgcagacca    240
 agaaagaggc aagtgctgag acagaatata tgaagcaaca atatgaagaa gaccttcgta    300
 aaatcaaaca tcagacagaa gaggagaaga aacatctcaa agaccagcta gtgaagcgac    360
 tagaagactt ggtaaagaag cacaccgtgg aaatcaaatc cgttcgctcg tccgtggagg    420
 ctgaaagaaa gaaactgcag agggaagtag aagcacagtt ggaggaagtg aggaagaaat    480
 cagaaaagga gataaagcag ctggaagaag agaaagcagc cctcaatgtg aagcttcaga    540
 attctctgct tgag                                                      554



      <210> 1420
      <211> 800
      <212> DNA
      <213> Homo sapiens


      <400> 1420
 attttgtgtt ggatccctat tctggagtca taaagtcaaa tgtctcattt gatagagagc     60
 agcagagttc ctacactttt gatgtcaaag ccactgatgg aggacaacca cctcgttcct    120
 ctactgcaaa agtaactatc aacgtcatgg atgtcaatga caacagccca gttgtcattt    180
 ctccaccgtc taatacttcc tttaagttgg tgcccctctc agccattcct ggctccgtgg    240
 tagcagaagt ttttgcagtg gatgttgaca ctggaatgaa cgctgaacta aagtatacta    300
 tagtgagtgg aaacaataaa ggcttattcc ggattgatcc agtaacaggt aacattactc    360
 tggaagaaaa accagcacct actgatgtgg gattgcatcg tttggtggtc aacataagtg    420
 acctggggta ccctaagtct ttgcacacgc ttgtgcttgt attcctttat gttaacgaca    480
 ctgctggaaa tgcctcctat atctatgact tgatccgcag gactatggag accccgttgg    540
 acaggaacat aggggatagt agccaaccct atcaaaatga ggactatcta accatcatga    600
 ttgccatcat cgccggtgcc atggtggtca ttgttgtgat cttcgtcacc gttctggtgc    660
 gctgtcgcca tgcatcaagg ttcaaagcag ctcagaggag caagcaaggt gccgaatgga    720
 tgtccccaaa ccaggagaac aagcaaaaca agaaaaagaa aagaaagaaa aggaagtctc    780
 ccaaaagctc tcttttgaac                                                800



      <210> 1421
      <211> 2783
      <212> DNA
      <213> Homo sapiens


      <400> 1421
 ggctggaatg gttcctggaa tgataattta gtggatacca gcccgctgaa gagagaccct     60
 ctgcaggaca tttgcaggag atacatggaa gatctgaaaa agatctgttt ttacagggag    120
 ttaaactcga agaccacctt gaaatttgtg cacacatctt ttcatggggt cggacatgac    180
 tatgtgcagt tggcttttaa agtgtttggt tttaagcctc caattccagt accagaacaa    240
 aaagatcctg atccagactt ttctaccgtt aaatgtccaa atcctgaaga aggagaatct    300
 gtgctggaac tttccttgag actggcagag aaagaaaatg cccgggtagt gctagccaca    360
 gatcctgatg cagacagact ggcagcagca gaacttcagg agaatggttg ttggaaagtt    420
 ttcacaggga atgagttggc agctttgttt ggatggtgga tgtttgattg ctggaagaaa    480
 aataaatcaa gaaatgctga tgtgaagaac gtttatatgt tagccaccac agtctcttct    540
 aaaattctga aggcaattgc acttaaagaa ggatttcatt ttgaagaaac attaccaggt    600
 tttaaatgga ttggaagtag gataatagac ctcctggaaa atgggaaaga agtccttttt    660
 gcatttgaag agtctattgg ttttctctgt ggaacttcag ttttggataa agatggggtg    720
 agtgcagctg ttgtggttgc tgagatggca tcttacctgg aaaccatgaa tataacattg    780
 aaacagcaac tggttaaggt ttatgaaaaa tatggttatc atatttcaaa aacttcctat    840
 ttcttgtgtt atgaaccacc taccatcaaa agtatatttg aaaggcttcg taattttgat    900
 tctccaaaag aatatccaaa attttgtgga acatttgcta tattgcatgt acgggacgtt    960
 accactggat atgacagtag ccagcctaat aagaaatcag tgctgcctgt gagtaaaaac   1020
 agccaaatga ttacatttac ttttcaaaat ggctgtgttg ctacccttcg gacaagtgga   1080
 acagaaccaa agataaagta ttatgcagag atgtgtgcgt cacctgacca gagtgacact   1140
 gctttactgg aggaagaact gaagaaactc attgatgctc tgatagagaa ttttcttcag   1200
 cctagtaaga atgggactgg atctggccgt tcctgtttag gggtaccccc caataccgtc   1260
 atgacactgt gtggggcata tgggaacaga gcaacccgaa gaaactgcca tacattggaa   1320
 ccttgtggtt agcattctct ctcctatctc atctggccga gtatcttttt ccttttattt   1380
 tctttctttt tggtcaactg gctagactaa acaaagtata agtttgaaat gaaatggtct   1440
 agagggaaat gattcaaatt ttttcataat tcaaacaaaa gttattacac taaaagtatt   1500
 atagtaacgt attgtccttc cgttaacaga aacatcacaa ttcaaaagtg agttttctta   1560
 ttatagtgtg attaagccta gttctgtatc tcgtaattgt gtatagcatg gtaaaagaaa   1620
 aaaaaaaaga caggtaaatg ttatataatt gtagggttag ttaaggaaat tagtccataa   1680
 aattggcaag aaaatggtac tttccttgat tgttatgaaa aagtgtcatt gtgacatcac   1740
 aggtattaat ttacaaatta gagtatttga aataggatat ttagcatttc tgtagtttaa   1800
 aacagatgtt acagtgtgtg gttttggcat gtctgtttca ggtgcccttg gtgcagtata   1860
 aatttactgt atgtatttaa aattctgatg tttactgaac ataaaacaat agtggcaaca   1920
 ctcctattgg ctttgttctt atcaaatttc tcagtgcctt ctcagggtct ggtatgaaca   1980
 gaaaaaacag tgttcctgca tttaccataa tttaatcagt caatttgcag atagctaagg   2040
 aaaatcttcc aaaatctgta ggtgcttcct ctatatcaag tgagtttact gattttaaaa   2100
 tcttaggaat ataaataaag atcttaataa aagcaagctt aatgtagtta aggatcttca   2160
 tattagaatt gtgtcattta tcaaaccttt tattacagaa aaaaatctga actgagaaag   2220
 gagctctgaa tttatttgac agtctaactt ttgaattaca tttttgtaag tagatttatt   2280
 cttttatttt atgaagtaat gttaatttta ctaagaataa aacatccaaa ttttaagtat   2340
 tatgaaatac taaaactaca tgttttaaaa cagaggtcca gtttattcta acatcttgct   2400
 gacttctgta gaatttctga ttgcatgact attatttatc ttcttttagt gtagaaaata   2460
 attttttaca aaaagtcact tttgggctgg gcgcagtggc tcacgcctgt aatcccagca   2520
 ctttgggagg ctgaggcagg tggatcacaa tgtcaggagt ttgagactag cctggccaat   2580
 atggtgaaac cctgtctcta ctaaaaatac aaaaattagc cgggtgtggt ggtgggcacc   2640
 tgtagtccca gctactcggg aggctgaggc aggagaattg cttgaaccta ggaggctgag   2700
 attgcagtga gccgaaatca cgccactaca ctccagcctg tgcaacagag ggagactcca   2760
 tctcaaaaaa aaaaaaaagt cac                                           2783



      <210> 1422
      <211> 3235
      <212> DNA
      <213> Homo sapiens


      <400> 1422
 actcggttta gagggcttcg gccggcggtg gccccatgga cagccctgct ggcactgggc     60
 ctgcctggct gggtgttggc tgtctcagcc acggcggctg ctgtggtccc cgagcagcat    120
 gcctccgtag ctggccagca tcccctggac tggctgctca cagaccgggg ccccttccac    180
 cgcgctcagg agtatgctga cttcatggag cggtaccgcc agggtttcac caccaggtac    240
 aggatttata gggagtttgc ccgttggaag gtgaacaact tggctctgga aaggaaggac    300
 ttcttcagtt tgccattgcc tcttgcccca gagtttatcc ggaacattcg cctccttgga    360
 aggagaccca atctgcaaca ggttacagaa aatctgatta aaaagtacgg cactcatttc    420
 ttactttctg ccacccttgg aggagaagag tccctgacca tttttgtgga caagcagaaa    480
 ctgggaagaa agacagagac aacaggaggt gcctctataa tcgggggcag tgggaacagc    540
 acagctgtgt ccctggagac cctgcaccag ctggccgcct cctacttcat cgacagagag    600
 agcacgctgc gacggctgca ccatatccag atagccacgg gggccatcaa ggtcaccgag    660
 accaggaccg gtcctctggg ctgcagcaac tatgacaatc tggactcagt cagttctgtc    720
 ttggtacaga gtccagagaa caaagtacag ttacttggcc ttcaggtgct gctgcctgag    780
 tatctgcgtg agcgctttgt agctgcagca ctcagctaca tcacatgcag ctctgagggt    840
 gagctcgtct gcaaggagaa tgactgctgg tgcaagtgca gccccacctt ccctgaatgc    900
 aactgccctg atgctgacat ccaggccatg gaggacagcc tgctgcagat ccaggactcc    960
 tgggccactc acaaccggca gtttgaagag tcagaagagt tccaggccct gctgaaaagg   1020
 ctgcccgatg accggttcct gaactccaca gctatctccc agttctgggc catggacacc   1080
 agccttcagc accgctacca gcagctggga gctggcttga aagtgctgtt caaaaagacc   1140
 catcggatcc tacgccggct cttcaacctc tgcaagcgct gccatcgcca gcctcgcttc   1200
 cgcctgccca aggagaggtc cttgtcctac tggtggaacc gaatccagtc cctcctctac   1260
 tgtggggaaa gcacctttcc tggcactttc ctggaacaga gccacagctg cacctgcccc   1320
 tatgaccaat cttcctgcca gggccccatc ccatgtgcct tgggcgaagg gcccgcgtgt   1380
 gcccactgtg ctccagacaa tagcacacgc tgtgggagct gcaacccggg ctatgtgctg   1440
 gcccaggggc tgtgccggcc agaggtggcc gagtccctgg aaaactttct tgggctggag   1500
 acagacttgc aggacctgga gctaaagtac ctgctgcaga agcaggatag ccgcattgag   1560
 gtacactcca tcttcatcag caatgacatg cggctgggca gctggtttga cccttcctgg   1620
 aggaagcgca tgctgctcac cctgaagagc aacaagtaca agcctgggct ggtgcacgtg   1680
 atgttggcct tgtccttgca gatctgtctc accaagaaca gcaccctgga gcctgtcatg   1740
 gccatctacg tcaacccctt tgggggcagc cactctgaga gctggttcat gcctgtgaat   1800
 gagggcagct ttcctgactg ggaaaggact aacgtggatg cagctgccca gtgccaaaac   1860
 tggactatca ccttggggaa taggtggaag actttctttg agacagttca tgtttaccta   1920
 cggagccgaa tcaagtccct ggatgacagc tccaatgaga caatctacta tgagcccctg   1980
 gagatgactg atccctctaa gaatttgggt tacatgaaaa ttaacacctt ggcaggtctt   2040
 tggctacagc ctgccctttg acccagattg ctatccggga cttaattctc cagttggact   2100
 acccatatac tcaaggttcc caggactctg cactcttgca gctcattgag ctcagggacc   2160
 gggtgaacca gctttctcca cctggcaaag tccgacttga ccttttctcc tgcttgctcc   2220
 ggcatcggct taagctggcc aacaatgagg tgggcaggat ccagtcctcc ctgagggctt   2280
 tcaattctaa gctgccaaac cctgtggaat atgagaccgg caaactctgt agctaatggg   2340
 cagcccactt cagcactggg caaggagggg atccatgaat ctggggtaca aagataatct   2400
 aagccctcac cttagtgcca acagggtgtg ctcccacgag actttcagca tccagtagat   2460
 gggacctcga ggctcgagct gaagcaggcg agagagaaac agctactgcg tgcgtgcgcg   2520
 cacgcataca cacacacaca cacacactgg cacagggagg ctacaactaa gcagcctcag   2580
 atctgtaaag ttgattggtg ctttctaaaa tgaatgcaat tgaaagaaag gagccaagga   2640
 agagattaag aaaaagaacc agctgaacca tgaaacaaac aaaaatccta aaagtgattc   2700
 ttgtcattca agaaagcaag aggggacaac aatgggaggg gtcggagctc ttcccttccc   2760
 ctctgtggag tcacttttgt attcttttta accagatttc ttaaaatgtt gttgttttgt   2820
 gaatcctgac attggttctt acttttgtat gctgcctcct ctgtgccctc ccagacgctg   2880
 actgggaaac acaagaagta caaccaacag gaaccagcgc caagggcagg cagcggcctc   2940
 cttgctcccc tcccttactc ctccctctgc tgcctcctcc ccccaccaag tttcagggcc   3000
 ctggattgtt cccagttccc attgtggtcc cttcagagct cctttccaac agcatctctc   3060
 tgtcgaagaa agaagctctg tcaagttaga gagagacaat gtgtaggaaa tgttcttttt   3120
 taaaaaaaaa taacaaaaac aaaacaaaac tatttatttt gggattgttt tccttgttaa   3180
 tctgctccaa ccacctgaac atctaagtaa acatttatct ggtttaaaaa aaaaa        3235



      <210> 1423
      <211> 582
      <212> DNA
      <213> Homo sapiens


      <400> 1423
 tggtgcctga cgcctggaca cgtcggaatt cctggtcgac ccacgcgccc gcggacgcgt     60
 gggcggggcc tttgtccctc gctgtggcct gagctccagg tctcgtcttc agcgctctgt    120
 gtcctctgct cctagaggtc caggctctgt ggccctgtga cctgcaggta ttgggagatc    180
 tacagctaag acgccaggaa cccctggaag cctagaaatg gagaacctga agtctggagt    240
 gtatcctctc aaggaagcaa gtggatgccc tggggctgac aggaatcttc tggtgtactc    300
 tttttatgaa aaggggccat tgacatttag ggatgtggcc atagaatttt ctctggagga    360
 gtggcaatgc ctggacactg ctcagcagga tttgtataga aaagtgatgt tagagaacta    420
 cagaaacctg gtcttcttgg caggtattgc tgtttctaag ccagacctga tcacctgtct    480
 agagcaagga aaagagccct ggaatatgaa gagacatgcg atggtagatc aacccccagg    540
 taggtgagag tgaacacaac agacgacatg aatgagaggt cc                       582



      <210> 1424
      <211> 582
      <212> DNA
      <213> Homo sapiens


      <400> 1424
 tggtgcctga cgcctggaca cgtcggaatt cctggtcgac ccacgcgccc gcggacgcgt     60
 gggcggggcc tttgtccctc gctgtggcct gagctccagg tctcgtcttc agcgctctgt    120
 gtcctctgct cctagaggtc caggctctgt ggccctgtga cctgcaggta ttgggagatc    180
 tacagctaag acgccaggaa cccctggaag cctagaaatg gagaacctga agtctggagt    240
 gtatcctctc aaggaagcaa gtggatgccc tggggctgac aggaatcttc tggtgtactc    300
 tttttatgaa aaggggccat tgacatttag ggatgtggcc atagaatttt ctctggagga    360
 gtggcaatgc ctggacactg ctcagcagga tttgtataga aaagtgatgt tagagaacta    420
 cagaaacctg gtcttcttgg caggtattgc tgtttctaag ccagacctga tcacctgtct    480
 agagcaagga aaagagccct ggaatatgaa gagacatgcg atggtagatc aacccccagg    540
 taggtgagag tgaacacaac agacgacatg aatgagaggt cc                       582



      <210> 1425
      <211> 452
      <212> DNA
      <213> Homo sapiens


      <400> 1425
 ccgcagtacc gggtcctggc ttcggcctca gccccaccat ggtgacgctt gctgaactgc     60
 tggtgctcct ggccgctctc ctggccacgg tctcgggcta ttgtcgttag catcgacgcc    120
 catgctgaag agtgcttctt tgagcgggtc acctcgggca ccaagatggg cctcatcttc    180
 gaggcggagg atggcggctt cctggacatc gacgtggtga ttacattacc agatagggta    240
 agattaaacc tcgtttactg aagaaaaagg ggcagtagac ttaccgatct tttatggatg    300
 tcacattcaa attatgttat aatctccgga tgtcctggat gaatccaaac atacggaatc    360
 ataatcattg gcttcttctt acgtcaatta aattcttaat tacacaattc aggtcttctc    420
 tatcatactt gtctagttgt atacagtcag aa                                  452



      <210> 1426
      <211> 2137
      <212> DNA
      <213> Homo sapiens


      <400> 1426
 cccggaattt ccgggtcgac gatttcgtag attacaacgg tgatggcggg caagcggtcc     60
 ggctggagcc gggcggctct cctccagctc cttctcggcg tgaacctggg ggtgatgccg    120
 cccacccggg cccggagtct gcgcttcgtt accttgctgt accgccatgg agaccgttca    180
 ccagtgaaga catatcccaa ggacccctat caggaagaag aatggcccca ggggtttggt    240
 cagttaacca aggaggggat gctacagcac tgggaactgg gccaggccct gcggcagcgc    300
 tatcacggct tcctaaacac ctcttatcac cggcaagagg tttatgtgcg aagcacagac    360
 tttgaccgga ctctcatgag tgctgaggcc aacctggctg gactcttccc tcccaacggg    420
 atgcagcgct tcaacccgaa catctcgtgg cagcctattc ctgtgcacac tgtgcccatc    480
 actgaggaca ggctgctgaa gttcccgttg ggcccatgtc cccgttatga gcagctgcag    540
 aacgagaccc ggcagacacc agagtatcag aatgagagtt ctcggaatgc acaatttctg    600
 gacatggtgg ccaacgagac agggcttaca gacctgacac tggagaccgt ctggaatgtc    660
 tatgacacac tcttctgtga gcaaacgcac gggctgcgcc tgccgccctg ggcctcaccc    720
 caaaccatgc agcgtctcag ccggctaaag gacttcagct tccgcttcct cttcggaatc    780
 taccagcagg cggagaaggc ccggcttcag gggggagtcc tgctggctca gataaggaag    840
 aacctgaccc taatggcgac cacctcccag ctccccaagc tgctggttta ctctgcgcac    900
 gacactaccc tggttgccct gcaaatggca ctggatgtct acaatggtga acaagccccc    960
 tacgcctcct gccacatatt tgaactgtac caggaagatt ctgggaattt ctcagtggag   1020
 atgtactttc ggaacgagag tgacaaggcc ccctggccgc tcagcctgcc tggctgccct   1080
 caccgctgcc cactgcagga cttccttcgc ctcacagagc ccgtcgtgcc caaggattgg   1140
 cagcaggagt gccagctggc aagcggtcct gcagacacag aggtgattgt ggccttggct   1200
 gtatgtggct ccatcctctt cctcctcata gtgctgctcc tcaccgtcct cttccggatg   1260
 caggcccagc ctcctggcta ccgccacgtc gcagatgggg aggaccacgc ctgacaacca   1320
 ctcagccccc ttccctccac ctcctagggg aggtgggctg ggccctcgct cctgactgtt   1380
 gctgctcccc agcccatgga caggagatcc tgggttgggc ctccctctga tgaccccagc   1440
 cagatgagcg agtggggctc agcgtggccc atggtgcctg tcactcagca ttcccatgcc   1500
 tgatgtttac caagtgctgt gttggacact ggctttctcc aaacaggatt tgcctcctcc   1560
 acgctcccta cacacctgag atgtaaactg gcagtcagtg ttcactcagg acctaggatt   1620
 agaaaatggc agagttggtg ctggatccac cttgcacttc tatcaagccc tgttcttttt   1680
 cctccagcct gaagtcttcg gcaaatagct cagagggaca tggtcttgcc tctcagtgct   1740
 tattttagtg ggaaaaacag ctaataccag gggtacaaac attggctccc aaggaactgg   1800
 atcacccaac agccagccag ccacatttcc ctgtgtctgg ctagagccac cattagactc   1860
 agacagaatg cttcaggaat cgttgtcacc ccttcaactg gagcaggacg gaaggttgtc   1920
 tgtacttggg agggagtggg gagtggtggg aagggagttg cttgtcacac gaatcaggaa   1980
 actgctctcc ctcagctggg ctggggtctc cagggacctg agctacatgc aggttgtgag   2040
 ctggaaaaga aagttctaga ctgtggccca gaatagggct ggggcagctc ccagagaatg   2100
 aatagtgctg tttcctattg gactgataaa aaaaaaa                            2137



      <210> 1427
      <211> 469
      <212> DNA
      <213> Homo sapiens


      <400> 1427
 tttcgtggac tccccgcgct tcagggcgac cattgacgag gtggagacgg acgtggtgga     60
 gattgaggcc aaactggaca agctggtgaa gctgtgcagt ggcatggtgg aagccggtaa    120
 ggcctacgtc agcaccagca ggcttttcgt gagcggcgtc cgcgacctgt cccagcagtg    180
 ccagggcgac accgtcatct cggaatgtct gcagaggttc gctgacagcc tacaggaggt    240
 ggtgaactac cacatgatcc tgtttgacca ggcccagagg tccgtgcggc agcagctcca    300
 gagctttgtc aaagagtgag tggcccccag ggctggggga agaacactga ggccacgctc    360
 cctcccttgg aggggaaggg ggtctggggc agagcagaag caccttgtgc ccaggcctcc    420
 aagctgtgca gcggctccac aaggcaaaaa gctcagaagc agacagccg                469



      <210> 1428
      <211> 1788
      <212> DNA
      <213> Homo sapiens


      <400> 1428
 gcggccgctc gcgcgagtgc acgcggcagt ggttggtgag cttggacttc tcgctgaagc     60
 tcttctcgca ctcggggcac ttgaagggcc gctcgcctgt gtgagtccgc tggtggcgca    120
 gcaggtgcga ggggcggctg aagctcttgc cgcacaggct gcagatgaag gagacctcat    180
 gcttgcccgc gtgcacgcgc tgatggatca ccaagctgat gtgcaggcgg aagctcttct    240
 tgcactcggg gcacgtgtag ggccgctcac ccgtgtgcgt gatctggtgt ttggtcaggc    300
 tggacttgtg gctgaagctg ctgtcgcact cggggcactt gtagggctta gggccaccgc    360
 cgccgctacc agagctgggt gacttgggac gcggcttgag cgcgtgcttg gggttgaacg    420
 tgggcccgcg ttcgggtgag acgcagcctc cgcgcacgcg gtggatgcgc tggtgcagcg    480
 tgagctgttg cttgtgccgg aagctgatct cgcattcggc gcactcgtag ggcccctcct    540
 tgatgtggtt gcgctggtgg atgatgaggt tgatcttcag gcggaagctc ttgccgcact    600
 ccatgcatgt gaagggccgc tcgccgcgcc ggttccgctg ctgctggctc gaggccccgc    660
 ggttctcgct caggtgccgc tcaccgtgca cggagggcgc cagccttttc actgcggggt    720
 ttcctagctg caggggcggg gggctctcct cgccctcggg ggacatctcc ccgggcagcg    780
 gggtctggta catactggcc tcatatctcc cggacagctg cccaagggat tgcaagtgct    840
 gcggcagctc atcctcctcc tcctcttctt cctcctcgtc ttgttcctct gtcttgatca    900
 cgatcccctc cgtgcagttc ctctgctgca ccagcatctg cttcagttcg ctgaactcgc    960
 tggagccttc cgtggactcc tccagcgtgt tctctggctc ctgcatgtcc aggtctggct   1020
 gttccccaca ggggtcaccc agctctgagt cctggaagcc gtgctcttcc acctgtccca   1080
 tcaggggctc aggtgtctcc aaactttctg agccctcgtc gttggtctgt acctcgatct   1140
 taatcacgat cccatcgtgc gcagcactgg gatctgtcgg cgtttcgccc tcctcagagt   1200
 cttcctgctc ctgcatggtg ggccgctccc cgcgctccat ctgtgacatg aggtctggtt   1260
 tggaaattgc atagtccatg gaaaccaggg actcgtagtt gcccctcatc acgttcttgt   1320
 agagctcctt ctgccactca gacaggtttc cccactcctg ctccgagaag tgcacagcaa   1380
 catcatcaaa tgtgacaggg accttgggaa cttctccatt gctgccgggg ggcagccgca   1440
 ggatccagaa atttctgttt ttcagcaggt tctccatgtt ctccagccgc ctctgcagca   1500
 gcccatactc ctgcagcagg gtccccaaca cgacccactt gctctccaga tggttcgcga   1560
 actccacggc tgtcttctcg cagtcggcta tcttcttttc atttgtcccc gtcctgcctt   1620
 ccagggtcag tagcctcatg gcctgggcct ccagcttcct ctccactgct tggacggcag   1680
 cccacacagc caagcgggtg atctctgccg tggggagcgg ctgttccttc tggactgcag   1740
 aagagatctg gaaaggggtg tccttttggg aaaccgccca cgcgtccg                1788



      <210> 1429
      <211> 2223
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2223)
      <223> n = a,t,c or g


      <400> 1429
 ggtggtttac acagcacgca gaggaggctt tacagtatgt tgttggggag ctggtgctta     60
 ggtgttgtgc catctctgcc tagaatctgc ctaggagctg tgaggtagag gaagctttcc    120
 ttggtagctg tggagaggac acgtttcttg cgagtatggc tggagaagcc cccacctccg    180
 gtcccaacac aacggaacac atggagtttt gctgtggtgt ctggaggatc ctgtcttgag    240
 cttgcctttg cttaggctgg actgtgtaag acaagcactg tgaagtgttc caactttatt    300
 taaaaccaga cagccctgct accatgcccc cgctcctcag cattgctcta ggggaggagc    360
 tggatgaact atggcccttc tgccaagccc aggtgctagg ggaggaaccc cttgcttgag    420
 atgtacagga tggactcctc acttcttctg ggcttgtgcc ctggcccgtt gaatcttgtc    480
 agctgtggcc ccatctgtgg ctcccgtgca gtgggacaat acgaggctca gctcagcctc    540
 attccggtgt tcgatggcca catctgcagc ctgagccaca tcgccaacaa gaagcaaagc    600
 cttgaccttc tgctcgggac ccacgcggga agcatacttc ttggcttcgt atttgttatg    660
 ttgtttcatg cagatctcca caaaaggcag gtagccaatg ggtgatttct tgctcttgga    720
 aaacttctct agctcttccc aatcttccaa atctgccagg gcagtcagct tcagccacca    780
 gagcctcttg tcagggatgc ggaagtcacg tgccagctgc tctgcacgct tgttgtgacc    840
 gccaagaatg agggtggtaa ctgtgtcatg tagagacagg tctaggaact ggccccccag    900
 ctcgtcttct aggcgccgct gcagccgtag gagccgcatt tgatcctctg tagccttggc    960
 tgcaaactca ttcttggcct tgtagaaggc atcggcggct gtctgcagag ctgctactcg   1020
 cccctcaata cgctcttctg cagcatagct ggctcggatg tggaagctgc ccaattcctg   1080
 gtgattgtca tcctgattgt aaaggtcctt cagcgtctct agctcctgat gcttacagaa   1140
 ctgtcggtac aaactgaggg ccatgggctg attccgaagg gtcatgaaaa aatctcctcg   1200
 gttcagctcg ttcttcaggt gcagcaacac cgtgaacacc aggtcagtgt ccccgctctc   1260
 gatggccttg cttagtgcca gtttgctcct cttcatcttt aggagaaggg gtacctgctc   1320
 ccctgagcgt ggctcatact ccagcagctt gatggccagc tccgtgcggc cacaaccata   1380
 ggctcgtgca gcaatgtcgg agtaagagac accaggcgtg tcccccagct tctggttaat   1440
 ggctcgagcc acatcctcat ctgagacatc cttctgttgc accttgtagc aggcccagtg   1500
 ggccaggatc ctgctgacgc cctgtacttc aggaaggcgc aagtactcgc atatctggat   1560
 ggccaggggg taaagtctcc gcaacacgag cctgtccagc agcacctgga tggtgagctg   1620
 cttatattgg ctataggtga gcgggatccc gatgtgatag tcccgaacag cattgagcac   1680
 acgcaggtcc tgacacatgt gcacgaagct gtcgggtgga aatctgtcca ggaaacactt   1740
 tccgaaggag gcggccctga gcagactctt ctgcatgtct ggctggtgct catgtcctgc   1800
 agcctcaatg cactgctgca cggcctgggt cagctggccc agctcctgga tctcccgcag   1860
 gtactcgtcc gccttctggc tctctttctc atactccttc tgagcctcca ggagcagcgc   1920
 cccgggggcc attgaggcaa ttttgaagat ttcctcgctg gccgctggaa cctcatgcag   1980
 gaactcgtgg gtgctgcggg agaagatgcg gaccccatcg agctcaggca ccaggtagga   2040
 gtcctcatcc agcacaaact ggatgctctc gggtgcatcg cccaccacca tcagccgcct   2100
 ttcccaggcc accaccacgg ccctctcctt gctacgagga cgaaaacacc agaacatctg   2160
 ctttggaggt gcccggatgt tgcagttgag ctcncatagc ttctaanatt tccagaacac   2220
 tac                                                                 2223



      <210> 1430
      <211> 279
      <212> DNA
      <213> Homo sapiens


      <400> 1430
 tgacaggaag ggaagtgccc tggctgggca tcaagagact tttctggccc tttccctgcc     60
 aacactttgc tgtgtgacct tggctcccgc ctcggcctgc ctcctgctga tgctcctggc    120
 cctgcccctg gcggccccca gctgccccat gctctgcacc tgctactcat ccccgcccac    180
 cgtgagctgc caggccaaca acttctcctc tgtgccgctg tccctgccac ccagcactca    240
 gcgactcttc ctgcagaaca acctcatccg cacgctgcg                           279



      <210> 1431
      <211> 359
      <212> DNA
      <213> Homo sapiens


      <400> 1431
 atctcaggag aatccattta ctggagccag aaacctactc catcatcgaa cgccagccct     60
 tggtctgagc ctgcggctgt agatgtggaa ctcacagcat atgcattgtt ggcccagctt    120
 accaagccca gcctgactca aaaggagata gcgaaggcca ctagcatagt ggcttggttg    180
 gccaagcaac gcaatgcata tgggggcttc tcttctactc aggatactgt agttgctctc    240
 caagctcttg ccaaatatgc cactaccgcc tacgtgccat ctgaggagat caacctggtt    300
 gtaaaatcca ctgagaattt ccagcgcaca ttcaacatac aggcagttaa ccgaatggg     359



      <210> 1432
      <211> 331
      <212> DNA
      <213> Homo sapiens


      <400> 1432
 actgcaccgg agtgagcgcg accatcatgt ccatgctcgt ggtctttctc ttgctgtggg     60
 gtgtcacctg gggcccagtg acagaagcag ccatatttta tgagacgcag cccagcctgt    120
 gggcagagtc cgaatcactg ctgaaaccct tggccaaatt aatgacatat ttcaaaaact    180
 caacatattt gatcaggctt tttatgatct atcgctgcaa accagtgaaa tcaaagaaga    240
 agaaaaggaa ctgagaagaa ctacatataa actaccagtc aaaaatgaag aggtaaagaa    300
 tatgtcactt gaactcaact cataacttga g                                   331



      <210> 1433
      <211> 414
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(414)
      <223> n = a,t,c or g


      <400> 1433
 tgggaagacg cacacagcca ctgtagttga gttaaaccca tgggtggaat atgaatttcg     60
 ggttgtagcc agtaacaaaa ttggaggtgg agaaccaagt ttaccctcag aaaaagtaag    120
 aactgaagag gcagttccag aagtgcctcc ttctgaagtc aatggaggag gcggaagccg    180
 gtctgaactt gtgataacct gggatccagt ccctgaagaa ctacagaatg gtgaaggttt    240
 tgggtatgtt gttgctttcc gccctcttgg ggttaccacc tggatccaga cagtggtgac    300
 atcccctgac accccaagat atgtctttag gaatgaaagc atcgtgccat attcaccata    360
 tgaagttaaa gtgggtgttt ataataacaa aggtgaagga ccatttagcc cagn          414



      <210> 1434
      <211> 438
      <212> DNA
      <213> Homo sapiens


      <400> 1434
 tttccaatct tcatcatttg atactgaaca acaatcagct gactttaatt tcctctacag     60
 cgtttgatga tgtcttcgcc cttgaggagc tggatctgtc ctataataat ctagaaacca    120
 ttccttggga tgctgttgag aagatggtta gcttgcatac ccttagtttg gatcacaata    180
 tgattgataa cattcctaag gggaccttct cccatttgca caagatgact cggttagatg    240
 tgacatcaaa taaattgcag aagctaccac ctgaccctct ctttcagcga gctcaggtac    300
 tagcaacctc aggaatcata agcccatcta cttttgcatt aagttttggt ggaaacccct    360
 tgcattgcaa ttgtgaattg ttgtggttga ggcgtctgtc cagagaagat gacttagaga    420
 cctgtgcttc tcctccac                                                  438



      <210> 1435
      <211> 438
      <212> DNA
      <213> Homo sapiens


      <400> 1435
 tttccaatct tcatcatttg atactgaaca acaatcagct gactttaatt tcctctacag     60
 cgtttgatga tgtcttcgcc cttgaggagc tggatctgtc ctataataat ctagaaacca    120
 ttccttggga tgctgttgag aagatggtta gcttgcatac ccttagtttg gatcacaata    180
 tgattgataa cattcctaag gggaccttct cccatttgca caagatgact cggttagatg    240
 tgacatcaaa taaattgcag aagctaccac ctgaccctct ctttcagcga gctcaggtac    300
 tagcaacctc aggaatcata agcccatcta cttttgcatt aagttttggt ggaaacccct    360
 tgcattgcaa ttgtgaattg ttgtggttga ggcgtctgtc cagagaagat gacttagaga    420
 cctgtgcttc tcctccac                                                  438



      <210> 1436
      <211> 5773
      <212> DNA
      <213> Homo sapiens


      <400> 1436
 tttcgtgatc atagctgggg gaggctgagc gtgggagcgg tgctgccagt cctgcctgaa     60
 aacgcgaaat gagtcttgct tggttctccc tccactgggc gtgagagccc ctgcccagga    120
 ggcccaggac aaatggcccc atagtggaaa ctgggaagct tttaggcatc tgatcagagc    180
 gggagccagc cgggggacca cagtgctgga caggccaacc aactcaaact tgaagacatg    240
 aaatccccaa ggagaaccac tttgtgcctc atgtttattg tgatttattc ttccaaagct    300
 gcactgaact ggaattacga gtctactatt catcctttga gtcttcatga acatgaacca    360
 gctggtgaag aggcactgag gcaaaaacga gccgttgcca caaaaagtcc tacggctgaa    420
 gaatacactg ttaatattga gatcagtttt gaaaatgcat ccttcctgga tcctatcaaa    480
 gcctacttga acagcctcag ttttccaatt catgggaata acactgacca aattactgac    540
 attttgagca taaatgtgac aacagtctgc agacctgctg gaaatgaaat ctggtgctcc    600
 tgcgagacag gttatgggtg gcctcgggaa aggtgtcttc acaatctcat ttgtcaagag    660
 cgtgacgtct tcctcccagg gcaccattgc agttgcctta aagaactgcc tcccaatgga    720
 cctttttgcc tgcttcagga agatgttacc ctgaacatga gagtcagact aaatgtaggc    780
 tttcaagaag acctcatgaa cacttcctcc gccctctata ggtcctacaa gaccgacttg    840
 gaaacagcgt tccggaaggg ttacggaatt ttaccaggct tcaagggcgt gactgtgaca    900
 gggttcaagt ctggaagtgt ggttgtgaca tatgaagtca agactacacc accatcactt    960
 gagttaatac ataaagccaa tgaacaagtt gtacagagcc tcaatcagac ctacaaaatg   1020
 gactacaact cctttcaagc agttactatc aatgaaagca atttctttgt cacaccagaa   1080
 atcatctttg aaggggacac agtcagtctg gtgtgtgaaa aggaagtttt gtcctccaat   1140
 gtgtcttggc gctatgaaga acagcagttg gaaatccaga acagcagcag attctcgatt   1200
 tacaccgcac ttttcaacaa catgacttcg gtgtccaagc tcaccatcca caacatcact   1260
 ccaggtgatg caggtgaata tgtttgcaaa ctgatattag acatttttga atatgagtgc   1320
 aagaagaaaa tagatgttat gcccatccaa attttggcaa atgaagaaat gaaggtgatg   1380
 tgcgacaaca atcctgtatc tttgaactgc tgcagtcagg gtaatgttaa ttggagcaaa   1440
 gtagaatgga agcaggaagg aaaaataaat attccaggaa cccctgagac agacatagat   1500
 tctagctgca gcagatacac cctcaaggct gatggaaccc agtgcccaag cgggtcgtct   1560
 ggaacaacag tcatctacac ttgtgagttc atcagtgcct atggagccag aggcagtgca   1620
 aacataaaag tgacattcat ctctgtggcc aatctaacaa taaccccgga cccaatttct   1680
 gtttctgagg gacaaaactt ttctataaaa tgcatcagtg atgtgagtaa ctatgatgag   1740
 gtttattgga acacttctgc tggaattaaa atataccaaa gattttatac cacgaggagg   1800
 tatcttgatg gagcagaatc agtactgaca gtcaagacct cgaccaggga gtggaatgga   1860
 acctatcact gcatatttag atataagaat tcatacagta ttgcaaccaa agacgtcatt   1920
 gttcacccgc tgcctctaaa gctgaacatc atggttgatc ctttggaagc tactgtttca   1980
 tgcagtggtt cccatcacat caagtgctgc atagaggagg atggagacta caaagttact   2040
 ttccatatgg gttcctcatc ccttcctgct gcaaaagaag ttaacaaaaa acaagtgtgc   2100
 tacaaacaca atttcaatgc aagctcagtt tcctggtgtt caaaaactgt tgatgtgtgt   2160
 tgtcacttta ccaatgctgc taataattca gtttggagcc catctatgaa gctgaatctg   2220
 gttcctgggg aaaacatcac atgccaggat cccgtaatag gtgtcggaga gccggggaaa   2280
 gtcatccaga agctatgccg gttctcaaac gttcccagca gccctgagga gtcccattag   2340
 gcgggaccat cacttacaaa tgtgtaggct cccagtgggg ggtagaagag aaatgactgc   2400
 atctctgccc caataaacag tctgctccag atggctaagg ctttgatcaa gagcccctct   2460
 caggatgaga tgctccctac atacctgaag gatctttcta ttagcataga caaagcggaa   2520
 catgaaatca gctcttctcc tgggagtctg ggagccatta ttaacatcct tgatctgctc   2580
 tcaacagttc caacccaagt aaattcagaa atgatgacgc acgtgctctc tacggttaat   2640
 gtcatccttg gcaagcccgt cttgaacacc tggaaggttt tacaacagca atggaccaat   2700
 cagagttcac agctactaca ttcagtggaa agattttccc aagcattaca gtcaggagat   2760
 agccctcctt tgtccttctc ccaaactaat gtgcagatga gcagcacggt aatcaagtcc   2820
 agccacccag aaacctatca acagaggttt gttttcccat actttgacct ctggggcaat   2880
 gtggtcattg acaagagcta cctagaaaac ttgcagtcgg attcgtctat tgtcaccatg   2940
 gctttcccaa ctctccaagc catccttgct caggatatcc aggaaaataa ctttgcagag   3000
 agcttagtga tgacaaccac tgtcagccac aatacgacta tgccattcag gatttcaatg   3060
 acttttaaga acaatagccc ttcaggcggc gaaacgaagt gtgtcttctg gaacttcagg   3120
 cttgccaaca acacaggggg gtgggacagc agtgggtgct atgttgaaga aggtgatggg   3180
 gacaatgtca cctgtatctg tgaccaccta acatcattct ccatcctcat gtcccctgac   3240
 tccccagatc ctagttctct cctgggaata ctcctggata ttatttctta tgttggggtg   3300
 ggcttttcca tcttgagctt ggcagcctgt ctagttgtgg aagctgtggt gtggaaatcg   3360
 gtgaccaaga atcggacttc ttatatgcgc cacacctgca tagtgaatat cgctgcctcc   3420
 cttctgggtc gccaacacct ggttcattgg ggtcgctgcc atccaggaca atcgctacat   3480
 actctgcaag acagcctgtg tggctgccac cttcttcatc cacttcttct acctcagcgt   3540
 cttcttctgg atgctgacac tgggcctcat gctgttctat cgcctggttt tcattctgca   3600
 tgaaacaagc aggtccactc agaaagccat tgccttctgt cttggctatg gctgcccact   3660
 tgccatctcg gtcatcacgc tgggagccac ccagccccgg gaagtctata cgaggaagaa   3720
 tgtctgttgg ctcaactggg aggacaccaa ggccctgctg gctttcgcca tcccagcact   3780
 gatcattgtg gtggtgaaca taaccatcac tattgtggtc atcaccaaga tcctgaggcc   3840
 ttccattgga gacaagccat gcaagcagga gaagagcagc ctgtttcaga tcagcaagag   3900
 cattggggtc ctcacaccac tcttgggcct cacttggggt tttggtctca ccactgtgtt   3960
 cccagggacc aaccttgtgt tccatatcat atttgccatc ctcaatgtct tccagggatt   4020
 attcatttta ctctttggat gcctctggga tctgaaggta caggaagctt tgctgaataa   4080
 gttttcattg tcgagatggt cttcacagca ctcaaagtca acatccctgg gttcatccac   4140
 acctgtgttt tctatgagtt ctccaatatc aaggagattt aacaatttgt ttggtaaaac   4200
 aggaacgtat aatgtttcca ccccagaagc aaccagctca tccctggaaa actcatccag   4260
 tgcttcttcg ttgctcaact aagaacagga taatccaacc tacgtgacct cccggggaca   4320
 gtggctgtgc ttttaaaaag agatgcttgc aaagcaatgg ggaacgtgtt ctcggggcag   4380
 gtttccggga gcagatgcca aaaagacttt ttcatagaga agaggctttc ttttgtaaag   4440
 acagaataaa aataattgtt atgtttctgt ttgttccctc cccctccccc ttgtgtgata   4500
 ccacatgtgt atagtattta agtgaaactc aagccctcaa ggcccaactt ctctgtctat   4560
 attgtaatat agaatttcga agagacattt tcacttttta cacattgggc acaaagataa   4620
 gctttgatta aagtagtaag taaaaggcta cctaggaaat acttcagtga attctaagaa   4680
 ggaaggaagg aagaaaggaa ggaaagaagg gagggaaaca gggagaaagg gaaaaagaag   4740
 aaaaagagaa agatgaaaat aggaacaaat aaagacaaac aacattaagg gccatattgt   4800
 aagatttcca tgttaatgat ctaatataat cactcagtgc aacattgaga attttttttt   4860
 aatggctcaa aaatggaaac tgaaagcaag tcatggggaa tgaatacttt gggcagtatc   4920
 ttcctcatgt cttcttagct aagaggagga aaaaaaggct gaaaaaatag ggaggaaatt   4980
 ccttcatcag aacgacttca agtggataac aatatttata agaaatgaat ggaaggaaat   5040
 atgatcctcc tgagactaac tttgtatgtt aaggtttgaa ctaagtgaat gtatctgcag   5100
 aggaagtatt acaaagatat gtcattagat ccaagtgctg attaaatttt tatagtttat   5160
 cagaaaagcc ttatatttta gtttgttcca cattttgaaa gcaaaaaata tatatttgat   5220
 atacccttca attgccaaat ttgatatgtt gcactgaaga cagaccctgt catatattta   5280
 atggcttcaa gcaggtactt ctctgtgcat tatagaatag attttaataa tcttatagca   5340
 ttgtatatta ttattgctgt tgtcactgtt attattattg tggatactgg cccttggtgt   5400
 gttgcatagc tccctatgta ttctctgttt ccatctttaa gttcccagac caatatacat   5460
 taagagtttt gcatggtcta aattgtgttt attccaacca cgtggaaagc tcctggaaag   5520
 aaattttaca ttcggttgtt ctgtgctcct aatgacactt gaccttgttg aacaaatggc   5580
 agagcctttc ccaaggattt gattgtttgt gaattatctg catgtgtgct tttttttggt   5640
 gtgtatgtat ttcattaaaa aatataaata cttatgaaaa ttgcacgcat attagagtta   5700
 accatgtact attgatacag caacgctaca ttgcaaataa aagtccgatc ccaaaaggag   5760
 aatgagacaa aaa                                                      5773



      <210> 1437
      <211> 369
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(369)
      <223> n = a,t,c or g


      <400> 1437
 gctttccgga gtgattcacg tcttgcagaa catcagagag ttcatactgg agagagacct     60
 tacacatgta atgaatgtgg caaggttttt agtacaaaag catacctcgc atgtcatcaa    120
 aaacttcata ctggagagaa actttacgaa tgtgaagaat gtgacaaagt ttacattcgc    180
 aaatcacacc ttgaaagaca taggaggatt catacaggag agaaacctca caagtgtggt    240
 gattgtggta aagcctttaa ttcaccttca caccttatta ggcatcagag aatccatact    300
 ggacagaaat cttacaaatg tcatcagtgt ggcaaggtct ttagtctgag gtcactcctt    360
 gcagaacan                                                            369



      <210> 1438
      <211> 236
      <212> DNA
      <213> Homo sapiens


      <400> 1438
 catcagcggc caggaaggat tgcaagcagt cttagccagc gactattcat ttgcacagtt     60
 tagatatctc caaaggcttc tccttgttca tggaaggtgg tcttatttcc gaatgtgcaa    120
 attcttatgc tatttcttct ataagaattt tgcatttaca cttgtgcatt tctggtttgg    180
 tttcttctgt ggtttctcag cccagactgt ttatgaccag tggttcatca cccttg        236



      <210> 1439
      <211> 2653
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2653)
      <223> n = a,t,c or g


      <400> 1439
 gttccccttc ctttcctctg tccaattccc tgagaaagtg gctgacagag cccccccaga     60
 agtagctgga gggacctcag gcccccgaat gcctggagac agaggggtcc cccagtcctc    120
 agcctcactg gcaggcccgg aaagtgctga attcgggggt ctcaggcgag gaggacgtgg    180
 aagtgggcct cttccgggtc ctggagttgc tgggggtggc agtggtgcct gagtgatcat    240
 ccaaggtggc cgggtcttct tctggcatcg ttttcgcgga gacggtaaac agggagttat    300
 cgaaggacat gtctgtgctg tcgaagttaa tctgggccca gcaggattct cgatctcttt    360
 tcttctgtaa atttctgagt ttaacttttc tgaccaccag ggcaacagcc accagcccag    420
 caaggaggaa gagggcacca gccaggctca gggagagcac caagatccaa gtgggcactg    480
 ggaaggagac gttcacgggc tcgctgaggt ctgacagctg ggactggttg agctcaccta    540
 acactccata ctggcagtgg aagggtcccc ctggagcctt gctgctgccg ccgctcaggt    600
 taaatgtcac cccgcgctgg tccgtggggg cctgcaggag ctggaccacc tgcccccctc    660
 gatacagtgt gaaattcgcc cccgggaagt tcccaggggc catgcatgcg atgtggatgg    720
 ggtcctcttg gctgcttggg tacgggggca ccagccggat ggatggtgct gggatcgcca    780
 aggagccagc tgcaaagagc aagatggtcc agggcatctc tctctgcgtt tggctgggaa    840
 atccggctga ggccagaggg gcccaaggct ccccgccaac tcctcctggt ggcccttgag    900
 tctgagaccc ttggggtgca tggtggggcc acgcccctcc actgtctata agccaggaaa    960
 gctgagcact caatatgaac caagcctcat ctcaattctc acagccgcac tacagggtgg   1020
 tcgttccatc actcccgact tacgaggaaa ctgatacgct gatgcctcta aggcgcaaaa   1080
 ggcgtcgaac ctggaccacg ctcacagagc aagcaaaaca cgacgccaca gaccagaggg   1140
 tgacccggat gatggcggcc ggcgcggccc tagccctggc cttgtggcta ctaatgccac   1200
 cagtggaggt gggaggggcg gggcccccgc caatccagga cggtgagttc acgttcctgt   1260
 tgccggcggg gaggaagcag tgtttctacc agtccgcgcc ggccaacgca agcctcgaga   1320
 ccgaatacca ggtgatcgga ggtgctggac tggacgtgga cttcacgctg gagagccctc   1380
 agggcgtgct gttggtcagc gagtcccgca aggctgatgg ggtacacacg gtggagccaa   1440
 cggaggccgg ggactacaag ctgtgctttg acaactcctt cagcaccatc tccgagaagc   1500
 tggtgttctt tgaactgatc tttgacagcc tccaggatga cgaggaggtc gaaggatggg   1560
 cagaggctgt ggagcccgag gagatgctgg atgttaaaat ggaggacatc aaggagtcca   1620
 ttgagaccat gcggacccgg ctggagcgca gcatccagat gctcacgcta ctgcgggcct   1680
 tcgaggcacg tgaccgcaac ctgcaagagg gcaacttgga gcgggtcaac ttctggtcag   1740
 ctgtcaacgt ggcggtgctg ctgctggtgg ctgtgctgca ggtctgcacg ctcaagcgct   1800
 tcttccagga caagcgcccg gtgcccacgt agcccctgcc atggaaggaa gaacgggaca   1860
 aaggaggggc agcagggtgt gtgcatatga gacttggggg tccctcccca attttagttt   1920
 cctgccaaaa cgggagtgtg cagtcagggc ctgcggtctg gccccatgag tctccttccg   1980
 tcctcagcgg gcagggaaca cctctggctt gtagaaggga cggctcagtg gctgcaccga   2040
 cggtcctgga aatctcacat ggtgggcact gcagcgttgg aacgtgagcc tcggatttcc   2100
 tggcccctct actgtaaatg tgccttagcc taagcctccc atcctgtgtt agcgttgcct   2160
 ggtgtggggc agggcctaac aaggaaacct gggccctcca agccaggttg aggtctggta   2220
 acagaatgcc aggaaggggg cctggaagac cacctgcccc ggcccctctc ctgcaggggc   2280
 cccacacagg catgagggat ggcccggcca aagtctaggc agaagcctcc tataacaaag   2340
 ggtggtgtgg cctgggcatt ggagtcaata aattatggtc agaaaatcac aagagcctgc   2400
 tgattggggc tcagggacac cagccaggac agaccggccc ccgagggggc agccagacag   2460
 gtgggagggg cctcccacga agctcagaag aaaggtcgtg cgggagccga tggaggtggt   2520
 cgcctgggca ctcctggggg aatccctggg gggatccgaa ctggccgaga tgggatctga   2580
 ggcggggctg ggaagaggaa ttccaccaca tggactagtg tnctcgatnn anggnnntca   2640
 actggctgtc cct                                                      2653



      <210> 1440
      <211> 1383
      <212> DNA
      <213> Homo sapiens


      <400> 1440
 tttttttttt tttttttaaa gctccaaaca tttattgtgt caatgataag cacacttttt     60
 aaaagacaac atagaatgta tagaaacaag gggttgggga ctcatgcgca tttccacaat    120
 acaggtaatt aggttggctg gtttcagaag ggccagggca tcactcatga cagcgatggt    180
 ccacgggccc tctctatggg actgattcac tgttccaatg tgggtctgtt tttttgtttt    240
 tactttttat taaaaaatat aaataaaatg ggcgctgcag ggcctacggc tggaacggac    300
 tctgcaggac tctgtcttcg gcacaacggc ttcttggagg ctactgtcag aaaacatcac    360
 aaactagcag gatgacagac cacgctgacg tcgactgggc ggcacgcgtc caccccaccc    420
 ctgggggctt caaattttct cagaacttaa gggctctcga gcttccatcc gaaaactgcc    480
 acacatcttg agctctctgg gtactacgcc gaatgggggt gtgtgaagaa cccgcggggt    540
 caggggactt ccgtgttcgc tttctaagta gattcttaat ccatgagtgt tctgtgcgtg    600
 ttgcaagaga aaccatgcac tggtgaatgg ctgtttgcaa gttgtacatg tgtagctgct    660
 gggctcatct ttacaaatac cctgcggggc atattctgca ctcatcccag gcgtggggat    720
 tagagctcca tgtgcagaac gaggggagga gaggcccctc cagtgcagaa gtttatctgc    780
 tatgtgttcc tgtttggggc aaattcctct agatgacgtt gataaacaat cgtcatcctc    840
 tggcgtgacc tggatgccaa cctccacggg attggatgct tttttcatct cgattggtga    900
 aggggaaggt ggcttatcca cagctttttc taagcagagg ctgccattgc attgtttccg    960
 tttgtgctcg ataaaaataa gaatgtcccc caatgggaag ttcatctggc actgcccaca   1020
 ggtgaggagg tcatgatccc cttctggagc tcccaacggg ccgtggtctg gttcatcatc   1080
 tgtaagaatg gcttcaagag gctcgggcga gaattcccgt ttgcttaagt gctggggttt   1140
 gccttgcttg cggcgagaca tggtgggctg cggggcgggc ggcggcggcg gcggcggcgg   1200
 cggcgggcgg acgacggctc ggttcacatc gggagagccg ggttagaaag aaggagactc   1260
 cagagaaaat atcttcatca gtgccttttg acatccaaaa taaattagaa ataatacaaa   1320
 gatggcgcag ggaagatgaa ttgtgggaga gccgtcatgg ctttttttta agcaaaaaaa   1380
 aaa                                                                 1383



      <210> 1441
      <211> 2014
      <212> DNA
      <213> Homo sapiens


      <400> 1441
 tttttttttt ttactgtttt atccaaattt attctcaggg aaaaagaaag tagtggctct     60
 acgcaacttt ttcattcacc aaccaccttt ccatgcatca gaacctatgc tgtgattgtt    120
 agctgaactt caatagtttc cacctactta agagagatgc ctcaaacaaa ttaactttat    180
 tttcagacaa caggtccaag aagacttcac agctcaatca tgacgaacat gtggctgttt    240
 cctcacagcc aggaaccctc ggtattagaa gaaaactcca accccccaca ccatcatcta    300
 gcctcttttc tcactgtgaa gaactgatga gacagaattc ctgagaaggg aacatttagg    360
 taatctggga tagaagggca tggaaggact ggacaaaact aaggcctccc catggaagga    420
 agggaaaaga atattacaaa acagactaac cagaaaaacc aagaccccat caagtatcct    480
 tcagggataa aacaagaggc cactcctaga tgcctcctga ttaaaaggtt gtcccatgcc    540
 ctacagaggc ggaggataaa tcctaagaaa cagaaatgta taaccagccc caatgcttcc    600
 catacttctg cattaggtca gtgtgaacat ggctttgctc ccaatggtca gacctgacat    660
 gggtccttct gaagatggtg ggtcaggtat atcccagcca ccctcaccag agaatacatc    720
 tatgacaaac ccaaattcct aatcctgaag tactttgagc cactctacat tgtggccact    780
 caataataga ataaatttgt gaaaaagctg catgttttaa tttaggaaat gagtagaagt    840
 tcacaagcaa cccagaatag gtgccagcag tttgctccag tgggccacac cacagcagca    900
 gctcaggctc tgcagaatca ctgtgtccag tgcttcctga gatgttcttt cagctgagga    960
 atggaaggca gcagctgctg gcactcatga caacgaaggg gcagcttcaa gagctcaggc   1020
 atcccatctc ggacagttac tctaccagcc tcttgtacca tctcgatcac agcttgtgat   1080
 tctaggaagt attctgtatt gaaagaattc caatgttttt tgtttttaag gcaaggagaa   1140
 tcaaaatcct ggctgatcac atgaagatgt acatggctca tactcggaat ggcgtggtag   1200
 cccaatcgga agcggagttt gctggaccca gcaaaatcta caatcacctt ttcccccaca   1260
 gtgtgcatat gcttaaggag ttcaaggtgt tcccctggcc acagccttca gactggaaat   1320
 ggaggtccac ggtaagacca gccaatggta acgggccttt gggtatttat cctttatcac   1380
 caccacctgc tcatctttgt aaacctgcat tttggggtcc tgcatagaaa tcttcaagcc   1440
 ttgactccag tggcccaggg attccttttt gataggtgca tcttttccct tctttagggg   1500
 cacagagcat tggccagagt tgctcccagg ttccagccct gtcccagcct cagcttcctg   1560
 agcagcatcc ctttctatag aatcactgtt gcctgatctc tttctcttcc tgtgtgtttc   1620
 caggccaggg ttctttgcct cttcctcaaa ctctacaata tatggataaa gttcattcac   1680
 catgtggaga acctggccag gctgcagctt cacctcttgg tccttcccaa ttacgactga   1740
 gtcaatgctg gtgggattga ctcctacctg ctttaccttg acatatccct tgttacactc   1800
 tgctttcaac tgtacttgct gtcgagaaca tttcttatca gtgatcttgg tctctgggcc   1860
 acgcccaatc acaactgctt ccaaatgtgg aagtctgatt cgctggtgcc ggctgtcctg   1920
 tctcaccaac cagcacaccc gcatcatcac tctccagaag tcggagacgg acaaattcac   1980
 cctcgtgcca agcatggcgg aatgcatcta acag                               2014



      <210> 1442
      <211> 2014
      <212> DNA
      <213> Homo sapiens


      <400> 1442
 tttttttttt ttactgtttt atccaaattt attctcaggg aaaaagaaag tagtggctct     60
 acgcaacttt ttcattcacc aaccaccttt ccatgcatca gaacctatgc tgtgattgtt    120
 agctgaactt caatagtttc cacctactta agagagatgc ctcaaacaaa ttaactttat    180
 tttcagacaa caggtccaag aagacttcac agctcaatca tgacgaacat gtggctgttt    240
 cctcacagcc aggaaccctc ggtattagaa gaaaactcca accccccaca ccatcatcta    300
 gcctcttttc tcactgtgaa gaactgatga gacagaattc ctgagaaggg aacatttagg    360
 taatctggga tagaagggca tggaaggact ggacaaaact aaggcctccc catggaagga    420
 agggaaaaga atattacaaa acagactaac cagaaaaacc aagaccccat caagtatcct    480
 tcagggataa aacaagaggc cactcctaga tgcctcctga ttaaaaggtt gtcccatgcc    540
 ctacagaggc ggaggataaa tcctaagaaa cagaaatgta taaccagccc caatgcttcc    600
 catacttctg cattaggtca gtgtgaacat ggctttgctc ccaatggtca gacctgacat    660
 gggtccttct gaagatggtg ggtcaggtat atcccagcca ccctcaccag agaatacatc    720
 tatgacaaac ccaaattcct aatcctgaag tactttgagc cactctacat tgtggccact    780
 caataataga ataaatttgt gaaaaagctg catgttttaa tttaggaaat gagtagaagt    840
 tcacaagcaa cccagaatag gtgccagcag tttgctccag tgggccacac cacagcagca    900
 gctcaggctc tgcagaatca ctgtgtccag tgcttcctga gatgttcttt cagctgagga    960
 atggaaggca gcagctgctg gcactcatga caacgaaggg gcagcttcaa gagctcaggc   1020
 atcccatctc ggacagttac tctaccagcc tcttgtacca tctcgatcac agcttgtgat   1080
 tctaggaagt attctgtatt gaaagaattc caatgttttt tgtttttaag gcaaggagaa   1140
 tcaaaatcct ggctgatcac atgaagatgt acatggctca tactcggaat ggcgtggtag   1200
 cccaatcgga agcggagttt gctggaccca gcaaaatcta caatcacctt ttcccccaca   1260
 gtgtgcatat gcttaaggag ttcaaggtgt tcccctggcc acagccttca gactggaaat   1320
 ggaggtccac ggtaagacca gccaatggta acgggccttt gggtatttat cctttatcac   1380
 caccacctgc tcatctttgt aaacctgcat tttggggtcc tgcatagaaa tcttcaagcc   1440
 ttgactccag tggcccaggg attccttttt gataggtgca tcttttccct tctttagggg   1500
 cacagagcat tggccagagt tgctcccagg ttccagccct gtcccagcct cagcttcctg   1560
 agcagcatcc ctttctatag aatcactgtt gcctgatctc tttctcttcc tgtgtgtttc   1620
 caggccaggg ttctttgcct cttcctcaaa ctctacaata tatggataaa gttcattcac   1680
 catgtggaga acctggccag gctgcagctt cacctcttgg tccttcccaa ttacgactga   1740
 gtcaatgctg gtgggattga ctcctacctg ctttaccttg acatatccct tgttacactc   1800
 tgctttcaac tgtacttgct gtcgagaaca tttcttatca gtgatcttgg tctctgggcc   1860
 acgcccaatc acaactgctt ccaaatgtgg aagtctgatt cgctggtgcc ggctgtcctg   1920
 tctcaccaac cagcacaccc gcatcatcac tctccagaag tcggagacgg acaaattcac   1980
 cctcgtgcca agcatggcgg aatgcatcta acag                               2014



      <210> 1443
      <211> 2014
      <212> DNA
      <213> Homo sapiens


      <400> 1443
 tttttttttt ttactgtttt atccaaattt attctcaggg aaaaagaaag tagtggctct     60
 acgcaacttt ttcattcacc aaccaccttt ccatgcatca gaacctatgc tgtgattgtt    120
 agctgaactt caatagtttc cacctactta agagagatgc ctcaaacaaa ttaactttat    180
 tttcagacaa caggtccaag aagacttcac agctcaatca tgacgaacat gtggctgttt    240
 cctcacagcc aggaaccctc ggtattagaa gaaaactcca accccccaca ccatcatcta    300
 gcctcttttc tcactgtgaa gaactgatga gacagaattc ctgagaaggg aacatttagg    360
 taatctggga tagaagggca tggaaggact ggacaaaact aaggcctccc catggaagga    420
 agggaaaaga atattacaaa acagactaac cagaaaaacc aagaccccat caagtatcct    480
 tcagggataa aacaagaggc cactcctaga tgcctcctga ttaaaaggtt gtcccatgcc    540
 ctacagaggc ggaggataaa tcctaagaaa cagaaatgta taaccagccc caatgcttcc    600
 catacttctg cattaggtca gtgtgaacat ggctttgctc ccaatggtca gacctgacat    660
 gggtccttct gaagatggtg ggtcaggtat atcccagcca ccctcaccag agaatacatc    720
 tatgacaaac ccaaattcct aatcctgaag tactttgagc cactctacat tgtggccact    780
 caataataga ataaatttgt gaaaaagctg catgttttaa tttaggaaat gagtagaagt    840
 tcacaagcaa cccagaatag gtgccagcag tttgctccag tgggccacac cacagcagca    900
 gctcaggctc tgcagaatca ctgtgtccag tgcttcctga gatgttcttt cagctgagga    960
 atggaaggca gcagctgctg gcactcatga caacgaaggg gcagcttcaa gagctcaggc   1020
 atcccatctc ggacagttac tctaccagcc tcttgtacca tctcgatcac agcttgtgat   1080
 tctaggaagt attctgtatt gaaagaattc caatgttttt tgtttttaag gcaaggagaa   1140
 tcaaaatcct ggctgatcac atgaagatgt acatggctca tactcggaat ggcgtggtag   1200
 cccaatcgga agcggagttt gctggaccca gcaaaatcta caatcacctt ttcccccaca   1260
 gtgtgcatat gcttaaggag ttcaaggtgt tcccctggcc acagccttca gactggaaat   1320
 ggaggtccac ggtaagacca gccaatggta acgggccttt gggtatttat cctttatcac   1380
 caccacctgc tcatctttgt aaacctgcat tttggggtcc tgcatagaaa tcttcaagcc   1440
 ttgactccag tggcccaggg attccttttt gataggtgca tcttttccct tctttagggg   1500
 cacagagcat tggccagagt tgctcccagg ttccagccct gtcccagcct cagcttcctg   1560
 agcagcatcc ctttctatag aatcactgtt gcctgatctc tttctcttcc tgtgtgtttc   1620
 caggccaggg ttctttgcct cttcctcaaa ctctacaata tatggataaa gttcattcac   1680
 catgtggaga acctggccag gctgcagctt cacctcttgg tccttcccaa ttacgactga   1740
 gtcaatgctg gtgggattga ctcctacctg ctttaccttg acatatccct tgttacactc   1800
 tgctttcaac tgtacttgct gtcgagaaca tttcttatca gtgatcttgg tctctgggcc   1860
 acgcccaatc acaactgctt ccaaatgtgg aagtctgatt cgctggtgcc ggctgtcctg   1920
 tctcaccaac cagcacaccc gcatcatcac tctccagaag tcggagacgg acaaattcac   1980
 cctcgtgcca agcatggcgg aatgcatcta acag                               2014



      <210> 1444
      <211> 1779
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1779)
      <223> n = a,t,c or g


      <400> 1444
 tttttttttt atttccaaag gttttatttt atatattgtt tgaagctttc tcaggctttg     60
 cactaaatgc atgtcaggtg catattcaat ctctttcaaa ggaaacatgg cagttgagta    120
 tccagaacac aagtgagtac cgtatacttt aaaagaatgc ttacagagct ctcctcttcg    180
 gccatgagaa aaaaaaacaa gtacctgcag aagtgagcga tacccaatgc tctcccagac    240
 acacgcctgg ggtgcttact gtcaatgaca ctcctccaca ccaacatgtg gtccaaaata    300
 gaatccctct catcttccat tacactcttt taaaaaatgc agagaaaata tgaattaact    360
 catcttaaat gtgagagaaa cagggggaaa aggacaagtt aatgcacaag cacaatacac    420
 aatggtaatt tttcttttca aaagatatta tggaatgtat tactagcagc ataaattcca    480
 acaaaaagtt gggcacccag atttggttat ttagattaaa aatatttatt acaggcagat    540
 ttgcttttcc caggaaaaca tatcactgga aacatttgga gaatgcaaac tgggttaaac    600
 ctattcccaa gtccattatc aagtaaggta tccctaaaga aaaagatagg agtttaaaac    660
 tggggaagcc cacacacaat ttagacaggg gaaaagaaaa aaaaaactca taaaaaaagt    720
 cagaatgatc ctttacgttt tacagtcttt aattaagcac ataaaactgt actatttaat    780
 atatttctcc atgaactttt tgtgaaattc agatcgcagt gtgtcattta caaatctttt    840
 gtctttcttc tggtcatcta caccttttgc acagttcttg aagacaacgt catcatccca    900
 ccttctttta actttgaagt tggcctgagg ctgggatggg ccagtgagat taaggagagg    960
 gtttccgctc agaatgtttt ccatacgaat cctctcttct tcagcttttt gttcttgttc   1020
 cttcctggcc tgctcttcag ctctttcttt tttaattttt tccagttctg caagaagagc   1080
 tgcagtatca tcatcatcac tttcttcttc aaaatcttca tcttcctcat ctgttagagg   1140
 gtcatctgca tcaaggttgg cggcaggaat ctggtctaac cgtggctttt ttgacactga   1200
 agaggaggtt gtatgttctc gggttggacg atccctattt ttctctcttg cagcagctct   1260
 ctctctttct tccaactctc tcctgaagtc acggttacga acctcttcag gggcatcctg   1320
 agtagtctgt ctgtatttta tctttgtatg agagggtagg tctctgcttg aatactgctt   1380
 tgaaagttgg ctcaaatcac cttctccttt tccccttcca cctctggcag gttcaaaggt   1440
 tggcctggct gctgttgtca tcttttatgc tggggttcgc tttacgcagt aggcgagctg   1500
 cctgtacgct gcgatctcct cggcgggccc aagagctcca gacgcgcctg acaggcactc   1560
 ggttccgccc ctagcccgct gctccagggc ctccaccgcc cgcgctctgc actctgccgc   1620
 cgactccgac cccaactgcc ctttcccgtc ccatcgcgat aagaaagata atctcctatc   1680
 ctcttgccgc tcacactggc cgaggtccga tgcagcaggc tccgaagatc atacagacgc   1740
 gaattccacc acactgagta gtgaaacagt angagcact                          1779



      <210> 1445
      <211> 860
      <212> DNA
      <213> Homo sapiens


      <400> 1445
 tgcgaccacc aggatccgac tcagtggggg ccgcagccaa catgaggggc gagtcgaggt     60
 gcaaataggg ggacctgggc cccttcgctg gggcctcatc tgtggggatg actgggggac    120
 cctggaggcc atggtggcct gtaggcaact gggtctgggc tacgccaacc acggcctgca    180
 ggagacctgg tactgggact ctgggaatat aacagaggtg gtgatgagtg gagtgcgctg    240
 cacagggact gagctgtccc tggatcagtg tgcccatcat ggcacccaca tcacctgcaa    300
 gaggacaggg acccgcttca ctgctggagt catctgttct gagactgcat cagatctgtt    360
 gctgcactca gcactggtgc aggagaccgc ctacatcgaa gaccggcccc tgcatatgtt    420
 gtactgtgct gcggaagaga actgcctggc cagctcagcc cgctcagcca actggcccta    480
 tggtcaccgg cgtctgctcc gattctcctc ccagatccac aacctgggac gagctgactt    540
 caggcccaag gctgggcgcc actcctgggt gtggcacgag tgccatgggc attaccacag    600
 catggacttc ttcactcact atgatatcct caccccaaat ggcaccaagg tggctgaggg    660
 ccacaaagct agtttctgtc tcgaagacac tgagtgtcag gaggatgtct ccaagcggta    720
 tgagtgtgcc aactttggag agcaaggcat cactgtgggt tgctgggatc tctaccggca    780
 tgacattgac tgtcagtgga ttgacatcac ggatgtgaag ccaggaaact acattctgca    840
 tggtgtcatc aacccaactt                                                860



      <210> 1446
      <211> 972
      <212> DNA
      <213> Homo sapiens


      <400> 1446
 tttttttttt gatgttttag aactttaatt atgaaaaagg gataaacaat tcaagatggg     60
 ggaaccagcc ccaaactggg ctggggcaga gagagaccag tccccagcca tacaatagca    120
 gcaaggggaa gaccccaccc cacagatgct ctgccccagc ccttcccaga gaccttaaat    180
 aatttaaata gcagggatgg cggagggcag gttgcctttg gtgtctgccc aatgctaaga    240
 tgaggggcag cgccggccca gcctcagcct cgggcagggc tctggggctg ctgcagggct    300
 gggaggtatt tgagggcagc agccccatgg tggcgggaca agtcctggtg gaattcgtcc    360
 ttgagggcct ggaggcagtc acgataggtg gggctggagc ggaagcggga gatgtccagg    420
 cttggagcgt ggggcagatg gatggtgaag gcctcgggca gcaccaggag ctcatattcc    480
 tgggcatcca gctccacaat gtgggccact ttgttccagc cgaagcccac aaagcgagga    540
 tcatagcggg gacagtctcg tggcaccacc acgtagggtt catagttggc cgcccattgc    600
 acacggtacg gggcctgagc ctcccgccag cgggcatagt ctgtgggtgc gtggcctcgg    660
 ggccactcgt ggtacctgaa ggtgtagaga gtgcccgcat ccagcaaggc caacagctcc    720
 accttggaat gggggaagct gaagcggtag cgcagggtct caaatgccgg caccaccagt    780
 gctgccttgc gccggctgcc cagccccagc tgctcaatgg aggccctgag gtagtcgtag    840
 agagaatagg caggcaggaa gtcaatgtca ctgaggaaga cgtaaggcgt gagggcctgg    900
 gccaaggcca cgttgcgaag ctggttgacg gggtataggg ggctggctgg ggcacacaaa    960
 gagcctcgtg cc                                                        972



      <210> 1447
      <211> 1667
      <212> DNA
      <213> Homo sapiens


      <400> 1447
 tttttttttt ttataaatca gcaagtattt attttaaata ataaaacttg tggtttatac     60
 tcatacatat ttacaaaaat gctttgctat agaaaaatag aatcaatcac tgaatccaga    120
 ccaccacagt ggagaacctc ctggtgaagc tgtgtttttt cccacactgg aaacacagag    180
 tagccctgtt tctgcacacg ttagtgcacc gctgctacgt gtggccgccc agctgtctgc    240
 aggctgtgcc gaccactgcc tctgtctcca ggaagcagag gcagaagtga tccttgctga    300
 ggagggccat cgagtctccg cttaaatgcc agcacagaga gagcactgca aagtcgcctt    360
 ccccaggcac ctgcaccgac atgcagcccg ctggggacca caggtagagc ctgctgcctc    420
 ccgtgcagat ggccagccgc ggctgctgcg ggtcccactg aaacgcgcgc actggggaca    480
 gctgctcgag caccgcgaac agcctcagct tctgaatgtc ccagacccag acggcattgg    540
 gaatgttgtc gttccttgtc gccaggaagt agctgtcagg actaaatgcc agcattccta    600
 tgccgatttt cgggtttgct ctgtcggtaa caggtttcag tgtctgtaag gagactggga    660
 cagaggcgat ctcatattta ctctctgagc tcgggagagg gccggccccg gcccggggcg    720
 gcgggaagga gaggcagccc agtcccagct gtgggctctt ctcggcctcc ttatacacca    780
 ctatcttggg atcattaatg gctgcaggat gcccaaactc cgtgatcatt ttccaagtca    840
 cgtgattaag gatgcgcacc tttccatcat agctcccaac tgccaggaac tgactgctgg    900
 ggctccaggc cacagacttg atgcccaggg accactcgta agcgctgtac gtggacaaca    960
 accggccatc caatgagtac agcagaatct tgtactccaa gcaggtgtcc cacactgcca   1020
 gcacacagcc gtttggggcc cactcaatcc ctgtgagatc ctgggtgtcc gtatcaaaat   1080
 gccgcaggag ctgccaatca ctgcagacga agatgctcac gtaatctttg cagtcgcgcc   1140
 gttctgccag cgccatgtag cggccgtccc tggtgaaggt gattccctgc agacaagctt   1200
 tcgggtattt gatgtaagac acggattttg tgcacaagga ccagacggtt atccgcagat   1260
 ggaattccgt ggtgttgaga atgtggcgcc cgtccgggct ccagcacgag gccaccagcc   1320
 cggctgagcc ctcgtctatt ttgcagtgcc attcgggctg ctctaaagac cagacctgca   1380
 ccagccctcg cttgtacatg gcgcacagga tgaagagcga gtctgccgac cactcgatgt   1440
 gctggatctg gtctaggcac gtgtacagct gaaggatctg aagggtgttc acatcccgga   1500
 ccactaaccg gtactggaca caggaagcca ggtacttgcc gtccggggag aacttgcaga   1560
 gtaagctgga gagcttgaat acctcggaga agttcatggc cgccgcctgc cgcgggcgcc   1620
 accctgcgcc cgaaaacccg cgggacccct gggcgcgcac aacagcc                 1667



      <210> 1448
      <211> 1328
      <212> DNA
      <213> Homo sapiens


      <400> 1448
 tcctaaagtg ctgggattac aggtgtgagc caccgtgcct ggcggacata gtcttttaca     60
 aatcctgtta gtaaacgtca catcattcac aaactcatcc tttcagcaaa cactgagcat    120
 ctatcctgct agccacagtg ccaagcggtt taccttgatc caagctatcg tctatttctt    180
 ggaatctcac tcttcgctta gatggtttgt gttgcatttg ggcaggatga tctcctacag    240
 tatcattcct cttctttaat atggagacca atccttcagt aggaacaacc tctgcaatct    300
 ctatcctttt ggcaagatca tcaagagaaa gacagctctc atcagaaggc agattctcct    360
 ggagactata ggatgcttct tcaggagaga gatcttgaag gagatcggag tcgtcgtctt    420
 ggttatcttc ataggaaagg gaatcttcag tatcttttaa acatcctttt aaaaggctgt    480
 tcaaatagtc ttctgtttct ttgttgagtt ggtcgtcttt atctcccttt tcctctgggg    540
 ccatacacac ctctggaagc agtatgccta agtcagatat ttgattattt ccacagagca    600
 cattctcaga accgtctgag tcagcctgcg cctgtggtga ttttccatca ctgtctgtaa    660
 gatcaggctg ctgcagctca tttaattcat tgttctcaag ttggtctgtg ggcaacgcct    720
 cagaagcatc ccgaagtggc aaacggagtt ctttcctctg agcctgtgaa tatttaccct    780
 cagaaatcaa tgcaggaggt atacggtcac agcctggtga aatcaacggc tctgtctttg    840
 acttgctgga aagaaacacc ttagggtctt cagcaatgcc ctctattctg gccacatcct    900
 ggcaggcctc tgtttgagcc agctgcaagc gactgtcatc ctcacaagca tcctcagaag    960
 agtctggccc agacgggctc cctgctgtct cggaggactg ggtgtggagc gctaacgtgg   1020
 cttcagcgct gcagagcagc tcctccatgt ggtcctttcc tgcagttacc gaaaggcttg   1080
 gggaatctgt ttgcacgtcc atctgatgac agcagggact gctccccagg ggctccactg   1140
 tatgttggct ttctttactt gactctgtgc cgagacaagt tttactctct aaagatgaag   1200
 aaaaataaat tgttaaaaat tcaaaacaac actttgtata ggaaggaaaa gaagggacat   1260
 atgaatatgt gtaatacagc aatattctaa ccctttcaaa tggaaatctg tctgttgcat   1320
 aatagtgt                                                            1328



      <210> 1449
      <211> 466
      <212> DNA
      <213> Homo sapiens


      <400> 1449
 ttttttttgt tcttcagatt tttatttaag ttaaattggt aaaatacaaa aagaaaatct     60
 ggattgagtt tcaaatcatc ttaaatagca atcctatgaa caattataac tgcaatttca    120
 aacactaaga cttaaatata caacttgatc atacaattat ctcaaaacat atgatcaaaa    180
 actttggtca agagcttctt tcatgaattc ttcaaggaca gctatcacat ttttggcttc    240
 aggcatttct tcatgttcca ctttaacaat cttcaaaagt atatctccac taccacagtt    300
 ctttaggaac atgtaacatt taaacaaagc ataatgattc atttctgcct gtcggataaa    360
 tctcttcaaa ttgtttgtgt cttgtatggc ctgcattgca gaactgaggc tgggagctgc    420
 tgcaatcgat gaccacagac ttatgctgct cctctgtcat gggcca                   466



      <210> 1450
      <211> 1659
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1659)
      <223> n = a,t,c or g


      <400> 1450
 cgagatttcg tcgctgctag ctcgcggcga cgtcgggccg attttcccag gatgacagag     60
 ctgaggcaga gggtggccca tgagccggtt gcgccacccg aggacaagga gtcagagtca    120
 gaagcaaagg tagatggaga gactgcatcg gacagtgaga gccgggcaga atccgcaccc    180
 ctgccagtct ctgcagatga taccccggag gtcctcaata gggccctttc caacttgtct    240
 tcaagatgga agaactggtg ggtgagaggc atcctgactt tggccatgat tgcatttttc    300
 ttcatcatca tttacctggg accaatggtt ttgatgataa tcgtgatgtg cgttcagatt    360
 aagtgtttcc atgagataat cactattggc tacaacgtct accactcata tgatctgccc    420
 tggttcagga cgctcagctg gtactttctc ctgagtgtaa actatttctt ctatggtgag    480
 acagtgacgg attacttctt caccctggtc cagagagaag agcctttgcg gattctcagt    540
 aaataccacc ggctcatttc ctttactctc tatctaatag gattctgcat gtttgtactg    600
 agtctggtca agaagcatta tcgactgcag ttctacatgt ttggctggac ccatgtgaca    660
 ttgctgattg ttgtaacaca gtcacatctt gttatccaca acctatttga aggaatgatc    720
 tggttcattg tccccatatc ttgtgtgatc tgtaatgaca tcatggccta tatgtttggc    780
 tttttctttg gtcggacccc actcatcaag ctgtccccga agaagacctg ggaaggcttc    840
 attgggggct tctttgctac tgtggtgttt ggccttctgc tgtcctatgt gatgtccggg    900
 tacagatgct ttgtctgccc tgtggagtac aacaatgaca ccaacagctt cactgtggac    960
 tgtgagccct cggacctgtt tcgcctgcag gagtacaaca ttcctggggt gatccagtca   1020
 gtcattggct ggaaaacggt ccggatgtac cccttccaga ttcacagcat cgctctctcc   1080
 acctttgcct cgctcattgg cccctttgga ggattcttcg caagtggatt caaacgagcc   1140
 tttaaaatca aagactttgc caataccatt cctggccatg gaggcatcat ggatcgcttt   1200
 gactgccagt atctgatggc cacctttgtc aatgtataca tcgccagttt tatcagaggc   1260
 cctaacccaa gcaaactgat tcagcagttc ctgactttac ggccagatca gcagctccac   1320
 atcttcaaca cgctgcggtc tcatctgatc gacaaaggga tgctgacatc caccacagag   1380
 gacgagtagg ggccacccag ggccaggaga acaggaacag aactgagcag gggcaggtct   1440
 ccaaggcaag cccagctggt gtgacttaga caatgacgag gcttcaactc actgtcnnnn   1500
 nnnnnnnnnn nngggggggt ttttttattt ggggggtcaa aaaatttggt ttatccagtt   1560
 tttgggttaa aatttggggt ggaaggaaac caacggtttg gggtgggagg gnnnnnnnnn   1620
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc ctttttaaa                          1659



      <210> 1451
      <211> 427
      <212> DNA
      <213> Homo sapiens


      <400> 1451
 ccacagctgg gtctcgaggt cctgtgcctt cgagccggcc tgggaggagg gggccacatc     60
 ccagaccgtg gccacgtgcg gcggggaggc tgtgtgcgta attgattgcc agacgggcat    120
 cgtgctccac aagtacaagg cacccggcga ggagttcttt tctgtggcct ggaccgctct    180
 gatggtggtc acacaggctg gccacaagaa gcgctggagt gtgctggcgg ctgcaggcct    240
 acggggcctg gtccggctgc tgcacgtgcg tgccggcttc tgctgcgggg tcatccgagc    300
 ccacaagaag gccatcgcca ccctgtgctt cagccccgcc cacgagaccc atctcttcac    360
 ggcctcctat gacaagcgga tcatcctctg ggacatcggg gtgcccaacc aggactacga    420
 attccag                                                              427



      <210> 1452
      <211> 1774
      <212> DNA
      <213> Homo sapiens


      <400> 1452
 cggacgcgtg ggcggacgcg cgggcgagga actagaggcg gaggcggggg cggaggaact     60
 ggagcaggcg gcagagggga aggaagtcag gttccaggcc tctctgccgc tgaccaggat    120
 cgatgaggaa gaggctgctg cagccccgga ggccgagaca gagcgggtgg agggggagga    180
 ataggacaag gaggagacgc agagagacgg cgcggagagc aaggagaggg atggggaagg    240
 acgcccggcc aaaagccagg aagaggggaa gcgcctctat ggaagggacg agtttgagga    300
 cctcgagtgg tccgaggagg tccagaagct gcaggagcag cagctgcgca gcgacctcct    360
 ggaccagtac cgttccctgc tggtggagcg gaaccgctcc cagcgctaca acctatacct    420
 gcagcacaag atcttcgagg cgctgcgcaa aaagaagggc ctggaggccg ctgaggtggc    480
 tgaccggggc gcagaggccg aggcccccga gaaagagcaa gcgtacctgc gccatctggg    540
 catgctggag gagctgaaga agcagcaggc agacgacctg cagtggtacc accaggagct    600
 gggccagttg aagcggcagt gccaggagaa gctcaccagg gtggagaagg agtggcgacg    660
 cttccaggca ctcaagaagc aggtggtgat gcaggccatg ggcagctgtc ggatgagggg    720
 cgggcgccag gctgctctgc gagaggtgga gcagatccag gcgttggagg ataaaaagga    780
 gaaggagatg agcgccgtgc ggctggagaa cattcagctg aagcagagcc tggtgcattt    840
 tgaaaccagg atgaggaccc aggaggacct gacccagggt ctgcttctta ttgactttga    900
 acagctgaag attgagaacc aaaccttcaa tgagaaaatt gaggaacgaa atgaggaact    960
 tttaaaactt cgcagcaagg tgaccaacag tgtgcaagta ataacccacg tgaaggaaaa   1020
 gctgcacttc atggacatgg agaacgcgtg caaaaagaca cagctggcag aaatcgaggc   1080
 ccaggccgcc ctaggaagag acatcctgac caagacgaag caagcccgag aggggctgcg   1140
 gacggacaac atcagactga atcagaagtg cggccttcta ggcaaggact cacttcttcg   1200
 ggacttggaa gaaaaggtgg acaagaccga actgcttcac cggcgcctgg aatccctgaa   1260
 gcgccaccac gctagcctca ctttgtcctg cagaggcgtg aggcagaaga tcagggaggc   1320
 caaagccttt ctcccttctt gaccagatcg atgagaagag tctgcaaaac acttcatcct   1380
 caggacgtgc tgtcctgctt tattttacct tcgttgctat ttaaaaaggc ctgtgttcat   1440
 ttggggacgg gactcttatt tttgtattta ttcttcaaaa cgttttagct tccaaatcag   1500
 tgctgagccc caacccccgg gttaggagtt ttatcctggg attgagcaaa aataggtccc   1560
 agaaaagcaa acaaagggtg atttaatgta actgacttct catgaaaaac tgtcaaaagt   1620
 ctcaagtctg agcaattcta taatttcagt gatgtaatac taaagagtac tgttcctctt   1680
 tcatatgtag gagggtttaa aagttcagcg aatgggcaag gtacaaaaaa accctgtgca   1740
 ttaagctaat tattaaattc tttggattta ttaa                               1774



      <210> 1453
      <211> 1086
      <212> DNA
      <213> Homo sapiens


      <400> 1453
 tttcgtgctc tgtgctggcg cctgctggcc actgagggac agggacacgt gccacctgct     60
 catctctgcc ctgaggtcac cccgtggtcc ctccacgtgc ccatctctct gcagtgccct    120
 cctcgcctgt gcagcccgcc cacccacagg ctcacccctc ctgccggctg ccagaggccc    180
 cctccagcag ggcctctctc cgttgcccca gcttcactct ctccctcagc acctgccctg    240
 ctggaggccc cagccctccg tggacagcag gggccacgtg gagcccgggc cgctcacccg    300
 ccacccagtg ctggccgcct tcttggtgcc aaaccccctt cccccaccca gagactgggc    360
 agctgtgtct ggttcgttct ttgcactaac cacatttgtc atctctaggg caggctgggg    420
 ctgcgggctg agggggaccg ctggcacccc ccttccctcc cttcttggtt ccatttccat    480
 ccatgacagg tacagcatcc caggagcccg gcctgagggg ctggacccga gccggctgtg    540
 aacatccctc agcccctgct gtcccccctt gggactaacc actaacctca cccccaaact    600
 ccacgggtgc ccctagctgg cccagagccg gcagtgtgag cccaagtccg ggctggagcc    660
 gaggccggag cagctgtctg ggaggcaagg ctgcagtagc gtttcttcat ggggtgctcc    720
 agggggtgcc acagaccgac aggcagccca agggcctgga cacccctccc caggcaggtg    780
 ctgccccagg aggactgtcc tcgggaatga acctcccgcg ggctttggac tgaggtccct    840
 gtggcctcgg tctcctcccc atgaagtggg agcgaggctc cccaatggtg cttttggctt    900
 tagtgtacga tgtttgctgt gcttcccgcc gtggagggca gagccacccc acatcaggat    960
 cggacgtgct acccctcccg gtcccggccc tggcccagcc agcccagccc tcgaggctcg   1020
 atgcctgtgc caaggccagg ggcagccaga gggcagctgg atggccacgt gcaggggtca   1080
 aggctg                                                              1086



      <210> 1454
      <211> 1794
      <212> DNA
      <213> Homo sapiens


      <400> 1454
 gaaagtacga gtcggctcag cctggaggga cccaaccaga gcctggcctg ggagccagga     60
 tggccatcca caaagccttg gtgatgtgcc tgggactgcc tctcttcctg ttcccagggg    120
 cctgggccca gggccatgtc ccacccggct gcagccaagg cctcaacccc ctgtactaca    180
 acctgtgtga ccgctctggg gcgtggggca tcgtcctgga ggccgtggct ggggcgggca    240
 ttgtcaccac gtttgtgctc accatcatcc tggtggccag cctccccttt gtgcaggaca    300
 ccaagaaacg gagcctgctg gggacccagg tattcttcct tctggggacc ctgggcctct    360
 tctgcctcgt gtttgcctgt gtggagaagc ccgacttctc cacctgtgcc tctcggcgct    420
 tcctctttgg ggttctgttc gccatctgct tctcttgtct ggcggctcac gtctttgccc    480
 tcaacttcct ggcccggaag aaccacgggc cccggggctg ggtgatcttc actgtggctc    540
 tgctgctgac cctggtagag gtcatcatca atacagagtg gctgatcatc accctggttc    600
 ggggcagtgg cgagggcggc cctcagggca acagcagcgc aggctgggcc gtggcctccc    660
 cctgtgccat cgccaacatg gactttgtca tggcactcat ctacgtcatg ctgctgctgc    720
 tgggtgcctt cctgggggcc tggcccgccc tgtgtggccg ctacaagcgc tggcgtaagc    780
 atggggtctt tgtgctcctc accacagcca cctccgttgc catatgggtg gtgtggatcg    840
 tcatgtatac ttacggcaac aagcagcaca acagtcccac ctgggatgac cccacgctgg    900
 ccatcgccct cgccgccaat gcctgggcct tcgtcctctt ctacgtcatc cccgaggtct    960
 cccaggtgac caagtccagc ccagagcaaa gctaccaggg ggacatgtac cccacccggg   1020
 gcgtgggcta tgagaccatc ctgaaagagc agaagggtca gagcatgttc gtggagaaca   1080
 aggccttttc catggatgag ccggttgcag ctaagaggcc ggtgtcacca tacagcgggt   1140
 acaatgggca gctgctgacc agtgtgtacc agcccactga gatggccctg atgcacaaag   1200
 ttccgtccga aggagcttac gacatcatcc tcccacgggc caccgccaac agccaggtga   1260
 tgggcagtgc caactcgacc ctgcgggctg aagacatgta ctcggcccag agccaccagg   1320
 cggccacacc gccgaaagac ggcaagaact ctcaggtctt tagaaacccc tacgtgtggg   1380
 actgagtcag cggtggcgag gagaggcggt cggatttggg gagggccctg aggacctggc   1440
 cccgggcaag ggactctcca ggctcctcct ccccctggca ggcccagcaa catgtgcccc   1500
 agatgtggaa gggcctccct ctctgccagt gtttgggtgg gtgtcatggg tgtccccacc   1560
 cactcctcag tgtttgtgga gtcgaggagc caaccccagc ctcctgccag gatcacctcg   1620
 gcggtcacac tccagccaaa tagtgttctc ggggtggtgg ctgggcagcg cctatgtttc   1680
 tctggagatt cctgcaacct caagagactt cccaggcgct caggcctgga tcttgctcct   1740
 ctgtgaggaa caagggtgcc taataaatac atttctgctt tattaaaaaa aaaa         1794



      <210> 1455
      <211> 2120
      <212> DNA
      <213> Homo sapiens


      <400> 1455
 catggctagc ccagccgcct cctcggtgcg accaccgagg cccaagaaag agccgcagac     60
 gctcgtcatc cccaagaatg cggcggagga gcagaagctc aagctggagc ggctcatgaa    120
 gaacccggac aaagcagttc caattccaga gaaaatgagt gaatgggcac ctcgacctcc    180
 cccagaattt gtccgagatg tcatgggttc aagtgctggg gccggcagtg gagagttcca    240
 cgtgtacaga catctgcgcc ggagagaata tcagcgacag gactacatgg atgccatggc    300
 tgagaagcaa aaattggatg cagagtttca gaaaagactg gaaaagaata aaattgctgc    360
 agaggagcag accgcaaagc gccggaagaa gcgccagaag ttaaaagaga agaaattact    420
 ggcaaagaag atgaaacttg aacagaagaa acaagaagga cccggtcagc ccaaggagca    480
 ggggtccagc agctctgcgg aggcatctgg aacagaggag gaggaggaag tgcccagttt    540
 caccatgggg cgatgacaat gtttgccaca gcctctgcct ggaacctggc tcgtgctgtg    600
 accagaaggg aaaggcggct gtttggctct ttctcccccg caaggacccg ctgacccgct    660
 ggatggagag caaaggagac ccctcccgag ccgctcacag tcctgtattt ggcaggtttg    720
 ggagcctgag gggccatctc cctgacactc agaggcactg ccttgcagac accatccgtg    780
 ctcctggtaa agggggacag agagcctcac cttgccacat atttgaacag tgatgagttt    840
 ggggctggtt tctgggaagg gaacgtttat ttagtaaaga gcagaacacc cttgcgtttt    900
 gttgggacat gtggaccgtg agtcgcaaac actctggaga aggctgagat gccaccattc    960
 ccacggggac tgaagacaca ttacgtggac ctggtcccag gctcagtgag gagatggcct   1020
 cagctgtggg gctggtccat gttgcccact cactccagtg ggaagtgggg accacgccat   1080
 agagggtctg ctcccactgc agctcccggt gctctcgtgt tctgggaagg cctgggtgtg   1140
 tgcacaagga ggcccgggcc agggacttca ccaggggctg ggtcacaagg gcacagggtg   1200
 tgtggaaagc gctgtggggg aagagccggt caccggagag tgagcaggcg gagactccaa   1260
 gctgggctga gccagagcag aaggcgaggg attcccagcc ggacgggggt tctctcacca   1320
 acagctgtga tttcatcccg aagtggaagg gggtctaaac agaacaggct gagagaggcg   1380
 ggactgggtc aagtgggtgg agctcctcct tgcatgactg caactgtcgg ggctttccgc   1440
 cggctcacag cagttggggc cagcggggag aagagaggcg gaactgctgt gtcctcatgt   1500
 ggcgcagcct caaactggca tccaggcact gggcccgtgc agagaaggca cctgcagaga   1560
 gcagggcagc ccggcgcagg ggcatgcgcc tagaatccca gctactcgga aggccaaggc   1620
 aggaggaccg cttgagtcca gggattcaag gccaacctgg gcaatagagc gagaccctgt   1680
 ctcttaaaaa acgatgatga tgaacacaga ggacggggca ctgtgctggg agccaggggg   1740
 cctgggagga gccgagacca gccttttacc tcggggtttt gaggccaaca gggacgacag   1800
 agacagtttc tagttagagc cttggctcca tttttggatg atttagcccc gagttcctga   1860
 gtctatttta tgccccttac gtactttgat agaactaagg aaatagtggt tttgagtgaa   1920
 gggaaaggaa acccagaaac attttacgtt gcttttactt ctgtagtgta gattgccccg   1980
 gcccctctct gagccctgta gcatctgtga tagcttctgt cccttcatcg gttcatgtca   2040
 cagggatttt ctttcccagg aagcggacac ggagagtcag ccctaataaa tgagcacatg   2100
 ccctggctgt aaaaaaaaaa                                               2120



      <210> 1456
      <211> 1006
      <212> DNA
      <213> Homo sapiens


      <400> 1456
 gtcgactttt cagaatgtga agattttact cttggcttaa tttttccctc cactcagtgc     60
 taagctgagc ctccagatgc tgttacctca gatttaatca ctggttgaaa ctccgtataa    120
 tctgtagagc ctccatggct ctaaaatttg gaattaactt ctctttcttt aaaatgaagc    180
 ttttatacat agctatccac atatgtacaa gcagctctta aggcaagaga agttaattcc    240
 aaattttaga gccatggagg ctctacagat tatacggagt ttcaaccagt gattaaatct    300
 gaggtaacag catctggagg ctcagcctta gcactgagtg gagggaaaaa ttaagccaag    360
 agtaaaatct tcacattctg aaaataatag tggcaaaaca taacactcct ggactgcggg    420
 aaataaaatt gagagggaca tgattagaag taaacttcta gaattctact aattccaggt    480
 tcttcaaatt ggtacaactg gtgacaatcc cagagtcacc agtcatcaca tcaaagtttg    540
 atagagaaag atgacccaca ggagcagcct tgctgtgctt gaggattgtt caacacttga    600
 aatgagcttc ggatcagttc ttggctgaag tccacctggg cccctttcac gaaggccaag    660
 ctatcagagt caaccaccac tcttgcccca ccctgttcaa ataccctgtc gtcggggttg    720
 ataactgtat ccagtgaaaa tttgtattgg aatccggagc atccacctcc ctccacttgc    780
 agcctgagga attctgaccc ttcggtgatt tccaaaagcc tctggacgca actgtctgtg    840
 aggcggatct gcccttcgcc ggcctcgggg ctggaggacg acgcctcccg acgcgcctgg    900
 ggtcccaggg aggccgtgag gagcctgccc ctcggccagg gagtgaccgc tctctgcgtc    960
 gcggccgtta gggacgaccc ccaggcggca gccatcttct cgtgcc                  1006



      <210> 1457
      <211> 1748
      <212> DNA
      <213> Homo sapiens


      <400> 1457
 tttttttttt ttcatacaaa cattatgtat ctttatttaa atttgcaaat gaaaacaaca     60
 catatttcat gttagtttta ataagagatt ccctatcctc tgccccagta aaacctaacc    120
 aagccagcct gacaggttat atcaatacag ggagctggag tgggagccaa gggtggtgtt    180
 agataggggt ggggtacaga tcaagggggc ctgggagact cagtgactgg aagtctctgc    240
 ccctcactct tggtgagtag ctaatttcag cagctggctt cataaggagg agtcaggggt    300
 gggtggaggc tcctcccaat tccagatcca cttcctcttc tccttctgtc tcctggacac    360
 ttaggtctta ctgagatggt tttcccacag taaagagagg tgggggcaga gtactaaggg    420
 tcaggagtgt gactctttcc catgactcag gcctctgtgc tagaggtgac ccttatagga    480
 aggagagacc ccaaatcctt tagccaatga gtggtggggt catcatacca gagagccagc    540
 ttgactctgg gcaggcacca tcacaggcac agcacccatg cggctcaagc cagaggaaga    600
 aaccccccca gggatggggg atattggttg agggtgggcc ccatctgtcg tgggcagtct    660
 tggtgagggc agggcctggc tggagagact gggcgtgggg gtcaatgcac caggcctggg    720
 agggccatgg ggtggccgga gggctcgtgc ggaggtgaca gaggaaaggg tcccattctt    780
 ggagattgtg tctgagctct tgggccaggg cagggtccgg ggagcaatgg catcctcctt    840
 gatatcattg gctggctcct ccagggcctt gccccggcgg tggtacaaga ggaccagccc    900
 agccagcaac cccagtccaa ccagggtacc cacaacagct ccagcaacca ctgcagctcc    960
 aggccctgtg ctcacttcca gcgtcacatt acattgggca gtgcccacct cattgtgggc   1020
 cttgcagaca tagactccag ccatggaaga cgaaaggttg gtgaggctta aagacccacg   1080
 gatgacatct aatgctggtg caaagaaagt ctggaaggat ggaagctgcc gatcccactg   1140
 gtattggaca gcgggcttac tccttggaga ctggcagctc agggtcacgt ttgcccccac   1200
 atggggcaca ccctggagac ggcaggatgg aggagctgga ggaaccagta cattgagttc   1260
 taaggttttg atgctgtggc ccctagattt gccttgtttg tcttgcacat tcacggagca   1320
 gctgtagggg ccagagtctt tctcctggag accctccagc cgcagggaca ggttccggga   1380
 gggcatggag tagaccaagg atactccagg tttgcttgtt gtgaccccat tgatgtagga   1440
 caacacctgg tgtggggcat aacacatccc cgtcattact acatgtgtct actgtgccta   1500
 caggctcagc cactctccct cccccagctc gcattctcca aatgcccctc acatgcaccc   1560
 attcttctaa cctgaaccag ctccccattc accttttgtc cctagccccc tctcactgcc   1620
 cctgggtcct cttcaccaga acagttcttc gttcctgcgc attgtctcat ctcccaattg   1680
 cggtgtttag aaaggtgaca taatagtggg aggagggaca tgtaaatagg aggtatgtat   1740
 ctcgtgcc                                                            1748



      <210> 1458
      <211> 841
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(841)
      <223> n = a,t,c or g


      <400> 1458
 tttttttttt ttcaccattg aagaacctgc attatcgttt attgtgatcc taattcggtc     60
 cacagtaaca attgaaactg cctcgactaa attttaagtt tctggggcag caccaccatg    120
 aaggcagcga ctgccttttt aaaagacagg gttctgacat tcagagattt ctgtttctct    180
 atccatcatt tttgggcatc ttgaatcacc tgatttagag tcagtgacat cctgactgga    240
 ttggttctgc tctcgctggg cgggtgagac ccccagaccc acgtccacag tgcacctgat    300
 gttctcccag cggtcgtcac ttccccaagg aggccaggta ggcataccag aacagagctg    360
 ccaggttggc gaagagcacc cggaacttca gagggacgta gttgatgttg atgaactgta    420
 gtggcgtcca cacccgccag ttcatcctca gcgccggcca gaagcccccc ctcatcttgg    480
 cggcgaaggc tgaggcgtct ttcccctcca gaaagttcat gatgaggaag aacaacatga    540
 ggaaggccgg tgcaaagacg aggcggtcca ggagaagcct cctgagccct gccaggggga    600
 cctcaggagg gatccaatgt tccatgaaga agtagaagaa gtgactcagc ggccctgtga    660
 agaagaaccc gtaaacggca tatctcagag gcccaccgac atccagactt ctagagtttt    720
 cttttttccg cttcttctca atcatctggg ccaggaagtt cccaagtgct gacaaaatgc    780
 cactggtggc cgccttggtg agcaccggga attccaccac ncggactaag gtcctcaagg    840
 t                                                                    841



      <210> 1459
      <211> 1249
      <212> DNA
      <213> Homo sapiens


      <400> 1459
 cccacgcgtc cggtgtttga ccaggtcaga actcttgttc tatgcgaatg tgctcacgca     60
 gacagaagcg gaggggctcc gtcgctctgc cctcacgccg ctgaaccgcg agggtctccc    120
 gctcctcagg cttgcggctc ggccgcgaag tgtgtcaggt gtgcatcctg ggtgctcctt    180
 tgtgctctgt cctacggcga cacaggcggc gtggggttag acaggtaccg gtcagactac    240
 ggtgacacag gcggcgtgcg gttagacagg taccggtcag attacggtgg cacaggcggc    300
 gtggggttag acaggtaccg gtcagattac ggtgacacag gcggcgtggg gttagacagg    360
 taccggtcag attacggtgg cacaggctgc gtggggttag acaggtaccg gtcagattac    420
 ggtggcacag gcggcgtggg gttagacagg tactggtcag atgcacgggc tccctaaacc    480
 cctgctgtgg cttcggcagt aaagacagga cgcacccatg tcacaagagg agcacaggca    540
 ggggtgttgg tgttggggca gccctcaggg tctccagacc ccagccccac tcacacagca    600
 gcctaggaag gaagggcaga gtcccaggtg tcagctggtg ggtctcccag gagctgcccc    660
 tccctggaag tcacaggaca ggaatgacag atcagggaac tgcaggaagc tgccacctct    720
 ggggtcagaa tatgcccagc ctgcgggggc tctctatcgg ggtcttcgag agccagacag    780
 cctgccttgt gctgcatacc tggctttgct ctgtgcagaa cccagcacac gtgattttgt    840
 gtgacatgcc agcagcctgg ctcccaggac aggaggcctg ccctggggga ggggctgcag    900
 gaggaggggg ggcaggcacc catgagtctg tccagccttg tcacagatgc atcgcccagc    960
 ctgcggtcct gatttcagct cacctcagag taaatcagaa taaactgcac ccagactttc   1020
 acgaatgcat gttgacgctt tcagttcacc cctttctttg ctaactttct tcctattttc   1080
 ttctaatgcg agagcttatt aattccatat ttatcatttt gaataacttt tctccttttt   1140
 aggttacaaa agtactttca ctcttagtaa aatgtattta ctattttagt aacaaaaata   1200
 tacttgccta atcatgttta aaatatagtg atgtgaaaaa ttctcgtgc               1249



      <210> 1460
      <211> 479
      <212> DNA
      <213> Homo sapiens


      <400> 1460
 tgatactgga cagaaaggct tgcctggccc tcctggcccc cctggctatg gatcacaggg     60
 aattaaaggg gaacaaggac cacaaggctt cccaggccca aagggcacaa tgggccatgg    120
 cctcccaggc cagaagggag agcacggaga acggggcgat gtgggaaaga aaggtgataa    180
 aggagaaatt ggagagcctg gatctccagg aaaacagggt ttacaaggac ccaaaggaga    240
 cctaggactt acaaaagaag aaattatcaa acttattaca gaaatatgtg gttgtgggcc    300
 caaatgcaaa gagactccac tagagctggt gtttgtgatc gacagctcag aaagcgtggg    360
 gccagagaac tttcagatca ttaaaaattt tgtgaagact atggctgacc gggttgctct    420
 ggaccttgcc acggcccgca taggcataat caactatagc cataaggtgg agaaggtgg     479



      <210> 1461
      <211> 2411
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2411)
      <223> n = a,t,c or g


      <400> 1461
 ggcacgagga gatgctgatc ctacagcact cccgctgtgc ctcagcagtg agctgggtgt     60
 aaaggcagga ggcttgctgg ggtctgacac ttccctgccc tcctccagga gggacacatc    120
 tggggctcta tgaggaggac agctttcatc ctgggctctg gacttctctc atttgtggcc    180
 ttctggaact cagtgacatg gcatcttcag agattttggg gtgcttctgg ctacttttgg    240
 caagcccagt gggagaggct gctgactaca tttgaaggga aggagtggat cctcttcttt    300
 ataggtgcca tccaagtgcc ttgtctcttc ttctggagct tcaatgggct tctattggtg    360
 gttgacacaa caggaaaacc taacttcatc tctcgctacc gaattcaggt cggcaagaat    420
 gaacctgtgg atcctgtgaa actgcgccag tctatccgca cagttctttt caaccagtgc    480
 atgatatctt tccccatggg tggtcttcct ctatcccttc ctcaaatggt ggagagaccc    540
 ctgacgccgt gagctaccca ccttccactg gttcctcctg gagctggcca tcttcacgct    600
 gatcgaggaa gtcttgttct actattcaca ccggctcctt caccacccaa cattctacaa    660
 gaaaatccac aagaaacacc atgagtggac agctcccatt ggcgtgatct ctctctatgc    720
 ccaccctata gagcatgcag tctccaacat gctaccggtg atagtgggcc cattagtaat    780
 gggctcccac ttgtcctcca tcaccatgtg gttttccttg gccctcatca tcaccaccat    840
 ctcccactgt ggctaccacc ttcccttcct gccttcgcct gaattccacg actaccacca    900
 tctcaagttc aaccagtgct atggggtgct gggtgtgctg gaccacctcc atgggactga    960
 caccatgttc aagcagacca aggcctacga gagacatgtc ctcctgctgg gcttcacccc   1020
 gctctctgag agcatcccag actccccaaa gaggatggag tgagagacag cctaagtgtc   1080
 atcctggctg tccctcagcc atgggatgca gacacggctt cctgattgca cctaacaatt   1140
 tgcctccttc ggccacacgc cctaatgatg gcaccaccag ggtagaggga aggtcggctt   1200
 cccggaaaag cagggccaag gatgaggctt tcttcaaact actgcccttg atgtccctca   1260
 atgggatcag gagttagctt aagaaaaagg aaaacacagc tccccagact ggaggctggt   1320
 cagagggagg agacccctgg tcctctgctg tggaaggaga ggggttcagc cccagataac   1380
 tcctttgtgg cctgggcagg atgcagagaa tgacaaggct gaaaggaggg ggactggagg   1440
 ctgcctggct ccagcgagag ctccttctgg gaccagaggg tgggacggcc aggtatcact   1500
 ttgccccttc ctgccccaaa aggctttcac atatccgact caggccagag ccaagacacc   1560
 ctggcaaatc gttataggtc tcaattcatg acataccaga tgccagtcgc cacttcaccc   1620
 aacacacaca caaacataca cacaccaaac actctgagtg agtggtaaag gccccgtttt   1680
 aactctggcc caccgcaaac aaaaggtttc cctctgtggg ggagaaaaag aaatccagga   1740
 gctcctccct ggattaaaac caacgaggtg cagaccaaac tttaacacct ttagccttat   1800
 gtggaaacca aaaaccaact gctgggaaac tgtgaaaagc ccttttaccc acaaggggag   1860
 gggtcaaagt tgctgccctt tggggacacc cgagacccct aattagccta tctgaatgag   1920
 gaccaaaggt tagagccctc tttctccccg aagaaagagc ccggaaaaac atggcagagc   1980
 aaagagcaaa atcctttctc ccccgaatgc tttaccagtt tctcagcaac atttattcaa   2040
 gatgattttt accaggaacc ttatcaaagg caaaaccaca gctgcttggg ttgaagtccc   2100
 catcctggcc tcctctcagc cgccagacat ggccaggaac cctgtggttc ccaagaacaa   2160
 tttaaagatc actctttgat ttgaaagacc accattatca ttttactaaa ttcttatata   2220
 tacttgtgcc ttttccaact ttcagttctc ttaagaaaaa catccactgt agctttataa   2280
 aataccttag tatcagctag ggtccaagtc tccaggcagg actatcaaaa tgggactcct   2340
 tcttcctatc agctctagaa ccccaganga cttgccagta ggccagctga gcacttacca   2400
 ggcagcatct t                                                        2411



      <210> 1462
      <211> 716
      <212> DNA
      <213> Homo sapiens


      <400> 1462
 gaaagagtgg gtaatgtgtg ttcactggaa atttctaaca ttcaaaaagg agaaggggga     60
 gagtacatgt gtcatgctgt aaacatcata ggggaagcaa agagctttgc aaatgtagac    120
 ataatgcccc aggaagaaag agtggtggca ctaccacctc cagaattttg tagatccaaa    180
 tatggattca agggagggag aagacaaaga actaaaaatt gatttagaag tatttgaaat    240
 gcctcctcgc tttataatgc ctatttgtga ttttaaaatt ccagaaaatt cagatgctgt    300
 attcaaatgt tcagtcatag ggatcccgac tcccgaagtt aagtggtata aagaatatat    360
 gtgtattgag ccagataata ttaaatacgt gattagcgag gagaagggaa gtcacactct    420
 taaaattcga aatgtctgtc tttctgatag tgcaacatac aggtgcagag ctgtgaattg    480
 tgtaggagag gctatctgtc ggggattcct caccatggga gattctgaaa tatttgctgt    540
 gatagcaaag aaaagcaaag tgactttaag cagtttaatg gaagaattgg tcttaaagag    600
 caactacaca gacagttttt ttgaatttca ggtgggggaa gggcctccca ggtttatcaa    660
 aggtatttct gactgttatg caccaatagg tacagcagca tattttcagt gcttag        716



      <210> 1463
      <211> 545
      <212> DNA
      <213> Homo sapiens


      <400> 1463
 ccgggtcgag ccacgcgtcc ggctggaggc agttgcttcc ctgtagaggg tccggctgcg     60
 gccagtattt tgtgtcatga cttctcaaga gaagacagaa gagtatcctt ttgcagatat    120
 atttgatgaa gatgaaactg aaaggaattt tttgttgtcc aaacctgttt gctttgttgt    180
 atttgggaaa ccaggtgttg ggaaaacaac attagcccgt tacataacac aggcatggaa    240
 atgtattcgt gttgaagctt tgccaatttt agaagaacag attgctgctg aaaccgaatc    300
 aggagttatg ttgcaatcaa tgttgatcag cggtcaaagc attccagatg aacttgtcat    360
 aaagctaatg ttggagaagc tcaactcccc agaagtctgt cactttggtt atattatcac    420
 tgaaatacca tcactttcac aggatgccat gactacctta cagcaaatag aattaattaa    480
 aaacttaaaa cctgaaacct gatgttataa tcaatataaa aggtgtcctt gacttttaat    540
 tgaat                                                                545



      <210> 1464
      <211> 1194
      <212> DNA
      <213> Homo sapiens


      <400> 1464
 ctttgtggca tcaaatcatt atgtttgtat gtttggaagg ccacgccatc tatcctccca     60
 cccagggcag gaatttctgc tcccactttt gctttcctgg aggtgaaata ggaagaacaa    120
 ggacccatgc tcaagtcccc aaagaatggc aggatgccct cagtggaggc agactgtatt    180
 taaatgcaat tcacctcttt ggggtctagg aaaagccacc cgtaggttca tttgctggga    240
 aacacggtct gcgtgcctga ggcagtggac accagggttg tggccttgcc aagagctgac    300
 tttctccgga ggtctgtctg ctgtccggag tggcagccac ttcggtgggc aaataggacg    360
 gtcatctctg ggcccaagga cgctgcttca ggctgggacg ccttgagggt ggctggctgt    420
 tcaggctttc cggaggtggg atgggaggtg taatgtttgg tgggaggagg gctgtaattc    480
 tgaaatctca cggttttgac ttgcttttcg atgccatttc ttgagttttc tggtttcacc    540
 aggatggatg gtggggcaga tgcgggcggt tttggcagag gctcactctt gatggggatt    600
 tctttgtctt ccataatgag ggagctggcc gcggagtgga tccgggcctc actgcccctg    660
 ctgatgcacg tgagggcggg ctcccccgtg agggcaggct tggaccccat ctccaccacc    720
 acggctgagg gggaggaggg gatcccctgt ggctggtaga attggaactg ctgaggccga    780
 aggaccatgg tggggctgcg tctgagggag cctaccacga gagtggggat cccggactgg    840
 aggggtctct gcagggatcc attctttctc atgctgctcc gccctttccg aagagaccct    900
 tgtcctaaag tcccagggcc ggctgtgctt ctcacggggt tgactatggc agtgggcaca    960
 aagacggatt tgaagggacg gctttgccgt ggatcacctt ctgaaatgct gccttgggag   1020
 gacacagagg aggtggataa cgtccatgtg gtgtagagac cagggctccg ggagtctgga   1080
 aaactagagg tctttctgaa aatggggatg acggtaattt ggtttgcaaa gaatgccgac   1140
 ttcgccccgt tggaccaagg gggacggccc cctggaggcc agaccgggcc ctgg         1194



      <210> 1465
      <211> 1194
      <212> DNA
      <213> Homo sapiens


      <400> 1465
 ctttgtggca tcaaatcatt atgtttgtat gtttggaagg ccacgccatc tatcctccca     60
 cccagggcag gaatttctgc tcccactttt gctttcctgg aggtgaaata ggaagaacaa    120
 ggacccatgc tcaagtcccc aaagaatggc aggatgccct cagtggaggc agactgtatt    180
 taaatgcaat tcacctcttt ggggtctagg aaaagccacc cgtaggttca tttgctggga    240
 aacacggtct gcgtgcctga ggcagtggac accagggttg tggccttgcc aagagctgac    300
 tttctccgga ggtctgtctg ctgtccggag tggcagccac ttcggtgggc aaataggacg    360
 gtcatctctg ggcccaagga cgctgcttca ggctgggacg ccttgagggt ggctggctgt    420
 tcaggctttc cggaggtggg atgggaggtg taatgtttgg tgggaggagg gctgtaattc    480
 tgaaatctca cggttttgac ttgcttttcg atgccatttc ttgagttttc tggtttcacc    540
 aggatggatg gtggggcaga tgcgggcggt tttggcagag gctcactctt gatggggatt    600
 tctttgtctt ccataatgag ggagctggcc gcggagtgga tccgggcctc actgcccctg    660
 ctgatgcacg tgagggcggg ctcccccgtg agggcaggct tggaccccat ctccaccacc    720
 acggctgagg gggaggaggg gatcccctgt ggctggtaga attggaactg ctgaggccga    780
 aggaccatgg tggggctgcg tctgagggag cctaccacga gagtggggat cccggactgg    840
 aggggtctct gcagggatcc attctttctc atgctgctcc gccctttccg aagagaccct    900
 tgtcctaaag tcccagggcc ggctgtgctt ctcacggggt tgactatggc agtgggcaca    960
 aagacggatt tgaagggacg gctttgccgt ggatcacctt ctgaaatgct gccttgggag   1020
 gacacagagg aggtggataa cgtccatgtg gtgtagagac cagggctccg ggagtctgga   1080
 aaactagagg tctttctgaa aatggggatg acggtaattt ggtttgcaaa gaatgccgac   1140
 ttcgccccgt tggaccaagg gggacggccc cctggaggcc agaccgggcc ctgg         1194



      <210> 1466
      <211> 1553
      <212> DNA
      <213> Homo sapiens


      <400> 1466
 ttaactttca aaacagtaaa caattttatt tatatttatt gtatacatac acaagaaaaa     60
 tacttatatt tatttttata tcatcatttt aaaattgaaa ttaatttgta gatataccta    120
 atcaacatct gtaagaattt caaaattttc aaaaagccag ataagccaat ttatttattt    180
 aaaactatta ataggcatat cactaagatt atatgacagt aaaaaaatga gaagattaac    240
 atatttgctt attagtgtaa acattattac actatattta gctttgtgta gagctttaca    300
 tatcaaaata tttaatatat aatactattt gttatgcagg ttttctaata ccttaaattt    360
 ttactatgta agcaattatt tgatgaattt accattctca aagattgaga ctgaaaagca    420
 gttcactgat cttacttttc gaaccagcat ctctttattt ttctacagta aattatactt    480
 ttgattatag agataagaat tatgagtatt catcattttt aaagaataaa catataaatc    540
 ttctttaagt gtactatcaa ataaatttta taaactcagt aattatcacc acatatttca    600
 aatagttact aatcccaaaa atatctgttc accttgaata tcttactgac atgttctcta    660
 tgtgagaaaa aaaatagttt cttttgttat ttgatggcaa tcatgagaaa ggtcttttta    720
 tcatcaagaa aacagaaaaa agtattggtt gagtgatggc agaaatgtag gccatgacat    780
 ctagatgagg tctatggaaa tacagcaaac ttttctaagc ataatgccat gtcatcatta    840
 ttagcaattt attttctgag atcactgatg ctggctatgt agaaaggctt atttaaattg    900
 aaaaagaaac atcattatgt ttctcatagc cagctaatct catagaacac ttacctgatt    960
 tgtgtggttt actgaatttt gtgaatttta agttttttac ctctttatat ccatgtgttt   1020
 gggcgcacac caggaataat catattgcat gtcaccctat cacttaaggt tatagaagta   1080
 atgacatcat caaaacagtc atatcagaaa taggaaaatt tagatgtatt catgtccttg   1140
 tgtcacaaag tgagagaaga gagtaaagac acctaggaaa atacaacgaa agaatgagat   1200
 atactcacaa cctcatgatc atggaattct aggctatata gctaagataa aataacagaa   1260
 tagataatat gaaaatagca aggttttcac caaattctat gtggctggaa ttaacaggat   1320
 taccccatca ggtctttctt gaatttggaa agatctattc cctcttttct atctttctag   1380
 ttttattaaa tttttgacag gaaaataaaa aacattttgt gaacaagaat atagcagttg   1440
 ccacacaggt cagcaggaac ccaatcacat ctatagagta gtgctggaac caggtgaggt   1500
 catgggcagc tgatcgcagg tgcttggctc ctttgtggcg catgacaaac tcg          1553



      <210> 1467
      <211> 791
      <212> DNA
      <213> Homo sapiens


      <400> 1467
 tttttttttt ttccaaaaaa acagccttta ttgagcagct attgggcagt gacgctgccg     60
 aggcgggaat cccaccacag tcctgaccgc agctgggacc cctttgcctc ctctgacacc    120
 cccacctcaa tttgataccc acttcctgag caaatgtgac ccctagggcc tgggattccc    180
 aaaatgacca ccccgaaatg cagcggcccc accgtctcct gaggccggtg aggccagggg    240
 gcagcagtgc ggctcagcag gtgcgaggca ggcttaggat ttcggaatca ccacctggaa    300
 cttacagacg ggcagggctg ccacggaggc ggtgaccacg ctctcaatgc ccagggtata    360
 gagggcgccg cgcaggaggc cgcaggtgaa ggccaggaac ttgggtgctt cctccagata    420
 ctgcaggcca gaggccatcg ggaggaggag ggggaagctg ttgtcttgca ggacgtaggt    480
 cccctggtga ttggtgcgca ggctgtccat ctgcttctgg aacaccgcca cccacaggtc    540
 tttgcacaag aacttgagga catccagctc ctccctgaag gccagcgtct cccggggcag    600
 cctctcgcct agagcctggc ccacacggaa ccccataccc tccaggaccg acaggctcat    660
 cttctgtccc cccgggccgg ggtcggggtc gtgagcccac agctcagcca ccatctccgt    720
 gtgaagaaac tcaaacaaca cagtatccgc catgccccct cctcgcacgc ctaaagatgc    780
 gccctcgtgc c                                                         791



      <210> 1468
      <211> 764
      <212> DNA
      <213> Homo sapiens


      <400> 1468
 tttttttttt ttatgattaa tttgttttct ttattgcaaa aaaaaagaat taaagaaaaa     60
 aacatttgtt caaaagctac ctcaaaagtc ctcctaccaa acatgatttg gcaatctttt    120
 tgcatgatta gtatgatggc agtaggagct ttgtttaata agcaaacatg atgaaaattc    180
 caaaaggtgc tatgcaaaag atcagaagga agatgttttt cctgagaccc tctgccaact    240
 gttacttctt ctgatgcctt tcctgcttct tgaacaaggc ttaagacagc ttctctgttc    300
 catttctgac cactatgtgg cacccagaac tttgaagtag gaaatagaaa aaaatctgct    360
 taactagtga tttgctgtga atctttaatc aatgcctctt aaaaataatt catttatggc    420
 cgggcgcagt ggctcatgcc tgcaatccca gcaccctggg aggccgaggc gggcggatca    480
 cgaggtcagg agatcaagac catcctggcc aacatggtga aaccccgtct ccaccaaaaa    540
 tacaaaaaat tagctgggca tggtggtagg tgcctgtagt cccagctact tgggagtctg    600
 aggcaggaga atggcgcgaa cccaggaggc ggagcctgca gtgagttgag atggggccac    660
 tgcacttcag cctgggcaac agaccgagac tccatctcaa aaaaataaat aaataaataa    720
 aaataattca tttatttttt tcagtgattt ggaatatggt ggct                     764



      <210> 1469
      <211> 2821
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2821)
      <223> n = a,t,c or g


      <400> 1469
 ccagggggca acaggagcag cagctcttct tgcaggaggt gcatttgcac tttttgcact     60
 tgcaggagcc ggcgcaggcg caggagccac cagcctcgca ggagcagttg gggtccattg    120
 caagccgagg tgagactgga gttcccaagc gagaagagaa gaggcagtgg aacacgtgga    180
 gggcgtggag ggagcacagg ggtggccagc gtagggtcca gcacgtgggg tggtacccca    240
 ggcctgggtc agacagggac atggcagggg acacaggaca gaggggtccc cagctgccac    300
 ctcacccacc gcaattcatt tagtagcagg cacaggggca gctccggcac ggctttctca    360
 ggcctatgcc ggagcctcga gggctggaga gcgggaagac aggcagtgct cggggagttg    420
 cagcaggaca tcaccaggag ggcgaagcgg ccacgggagg ggggccccgg gacattgcgc    480
 agcaaggagg ctgcaggggc tcggcctgcg ggcgccggtc ccacgaggca ctgcggccca    540
 gggtctggtg cggagagggc ccacagtgga cttggtgacg ctgtatgccc tcaccgctca    600
 gcccctgggg ctggcttggc agacagtaca gcatccaggg gagtcaaggg catggggcga    660
 gaccagacta ggcgaggcgg gcggggcgga gtgaatgagc cctcttcttc tttttcatcc    720
 cggtcacttt tggttacagg acgtggcagc tggttggacg aggggagctg gtgggcaggg    780
 tttgatccca gggcctgggc aacggaggtg tagctggcag cagcgggcag gtgaggaccc    840
 catctgccgg gcaggtgagt cccttccctc cccaggcctc gcttccccag ccttctgaaa    900
 gaaggaggtt taggggatcg agggctggcg gggagaagca gacaccctcc cagcagaggg    960
 gcaggatggg ggcaggagag ttagcaaagg tgacatcttc tcggggggag ccgagactgc   1020
 gcaaggctgg ggggttatgg gcccgttcca ggcagaaaga gcaagagggc agggagggag   1080
 cacaggggtg gccagcgtag ggtccagcac gtggggtggt accccaggcc tgggtcagac   1140
 agggacatgg caggggacac aggacagagg ggtccccagc tgccacctca cccaccgcaa   1200
 ttcatttagt agcaggcaca ggggcagctc cggcacggct ttctcaggcc tatgccggag   1260
 cctcgagggc tggagagcgg gaagacaggc agtgctcggg gagttgcagc aggacgtcac   1320
 caggagggcg aagcggccac gggagggggg ccccgggaca ttgcgcagca aggaggctgc   1380
 aggggctcgg cctgcgggcg ccggtcccac gaggcactgc ggcccagggt ctggtgcgga   1440
 gagggcccac agtggacttg gtgacgctgt atgccctcac cgctcagccc ctggggctgg   1500
 cttggcagac agtacagcat ccaggggagt caagggcatg gggcgagacc agactaggcg   1560
 aggcgggcgg ggcggagtga atgagctctc aggagggagg atggtgcagg caggggtgag   1620
 gagcgcagcg ggcggcgagc gggaggcact ggcctccaga gcccgtggcc aaggcgggcc   1680
 tcgcgggcgg cgacggagcc gggatcggtg cctcagcgtt cgggctggag acgaggccag   1740
 gtctccagct ggggtggacg tgcccaccag ctgccgaagg ccaagacgcc aggtccggtg   1800
 gacgtgacaa gcaggacatg acatggtccg gtgtgacggc gaggacagag gaggcgcgtc   1860
 cggccttcct gaacacctta ggctggtggg gctgcggcaa gaagcgggtc tgtttcttta   1920
 cttcctccac ggagtcggca cactatggct gccctctggg ctcccagaac ccacaacatg   1980
 aaaggtgagg ggcttcctgc cacacttggg gtggggggca cgcgagagga gctgagtggg   2040
 acctcactcc ttccccatcc acagaaatgg tgctacccag ctcaagcctg ggcctttgaa   2100
 tccggacaca aaaccctcta gcttggaaat gaatatgctg cactttacaa ccactgcact   2160
 acctgactca ggaatcggct ctggaaggtg aagctagagg aaccagacct catcagccca   2220
 acatcaaaga caccatcgga acagcagcgc ccgcagcacc caccccgcac cggcgactcc   2280
 atcttcatgg ccaccccctg cggcggacgg ttgaccacca gccaccacat catcccagag   2340
 ctgagctcct ccagcgggat gacgccgtcc ccaccacctc cctcttcttc tttttcatcc   2400
 ttctgtctct ttgtttctgg agctgagctt tcctgtcttt ccttttttct gagagattca   2460
 aagcctccac gactctgttt cccccgtccc ttctgaattt aatttgcact aagtcatttg   2520
 cactggttgg agttgtggag acggccttga gtctcagtac gagtgtggcg tgagtgtgga   2580
 ggccaccttt gggcaaagtg gctgtggcag gggcccgggc ggcccttcca tctggggccg   2640
 ggtgaatggg gcgccggctg tgtgccgagg cctcaccctg ccctcgccta gtctggaagc   2700
 tccgaccgac atcacggagc agccttcaag cattccatta cgccccatct cgctctgtgc   2760
 ccctccccan cagggcttca gcaggagccc tggactcatc atcaataaac actgttacag   2820
 c                                                                   2821



      <210> 1470
      <211> 1821
      <212> DNA
      <213> Homo sapiens


      <400> 1470
 tttcgtgagg aagttcaagg gcgagagtga gtaccagcag aaggctggga gtctgtagtt     60
 tgttcctgct gccaggctcc actgagggga acggggacct gtctgaagag aagatgcccc    120
 tgctgacact ctacctgctc ctcttctggc tctcaggcta ctccattgcc actcaaatca    180
 ccggtccaac aacagtgaat ggcttggagc ggggctcctt gaccgtgcag tgtgtttaca    240
 gatcaggctg ggagacctac ttgaagtggt ggtgtcgagg agctatttgg cgtgactgca    300
 agatccttgt taaaaccagt gggtcagagc aggaggtgaa gagggaccgg gtgtccatca    360
 aggacaatca gaaaaaccgc acgttcactg tgaccatgga ggatctcatg aaaactgatg    420
 ctgacactta ctggtgtgga attgagaaaa ctggaaatga ccttggggtc acagttcaag    480
 tgaccattga cccagcgtcg actcctgccc ccaccacgcc tacctccact acgtttacag    540
 caccagtcac ccaagaagaa actagcagct ccccaactct gaccggccac cacttggaca    600
 acaggcacaa gctcctgaag ctcagtgtcc tcctgcccct catcttcacc atattgctgc    660
 tgcttttggt ggccgcctca ctcttggctt ggaggatgat gaagtaccag cagaaagcag    720
 ccgggatgtc cccagagcag gtactgcagc ccctggaggg cgacctctgc tatgcagacc    780
 tgaccctgca gctggccgga acctccccgc aaaaggctac cacgaagctt tcctctgccc    840
 aggttgacca ggtggaagtg gaatatgtca ccatggcttc cttgccgaag gaggacattt    900
 cctatgcatc tctgaccttg ggtgctgagg atcaggaacc gacctactgc aacatgggcc    960
 acctcagtag ccacctcccc ggcaggggcc ctgaggagcc cacggaatac agcaccatca   1020
 gcaggcctta gcctgcactc caggctcctt cttggacccc aggctgtgag cacactcctg   1080
 cctcatcgac cgtctgcccc ctgctcccct catcaggacc aacccgggga ctggtgcctc   1140
 tgcctgatca gccagcattg cccctagctc tgggttgggc ttggggccaa gtctcagggg   1200
 gcttctagga gttggggttt tctaaacgtc ccctcctctc ctacatagtt gaggaggggg   1260
 ctagggatat gctctggggc tttcatggga atgatgaaga tgataatgag aaaaatgtta   1320
 tcattattat catgaagtac cattatcata atacaatgaa cctttattta ttgcctacca   1380
 catgttatgg gctgaataat ggcccccaaa gatatctgtg tcctaatcct cagaacttgt   1440
 gactgttacc ttctgtggca gaaagggaca gtgcagatgt atgtaagtta aggactttga   1500
 gatagagagg ttattcttgc tgattcaggt gggcccaaaa tatcaccaca agggtcctca   1560
 taagaaagag gccagaaggt caaagaggta gagacaaagt gatgatggaa gtggacgtgg   1620
 gtgtgacgtg agcaggggcc atgaatgccg cagccttcag atgccagaaa gggaaaggaa   1680
 tggattcccc tgcctggagc ctccaaaaga aaccagccct gcccacgcct tgacttgagc   1740
 ccattgaaac tgatcttgag ctcctggcct ccagaattgc aggagaataa atttgtgttg   1800
 tttttaatga gaaaaaaaaa a                                             1821



      <210> 1471
      <211> 1821
      <212> DNA
      <213> Homo sapiens


      <400> 1471
 tttcgtgagg aagttcaagg gcgagagtga gtaccagcag aaggctggga gtctgtagtt     60
 tgttcctgct gccaggctcc actgagggga acggggacct gtctgaagag aagatgcccc    120
 tgctgacact ctacctgctc ctcttctggc tctcaggcta ctccattgcc actcaaatca    180
 ccggtccaac aacagtgaat ggcttggagc ggggctcctt gaccgtgcag tgtgtttaca    240
 gatcaggctg ggagacctac ttgaagtggt ggtgtcgagg agctatttgg cgtgactgca    300
 agatccttgt taaaaccagt gggtcagagc aggaggtgaa gagggaccgg gtgtccatca    360
 aggacaatca gaaaaaccgc acgttcactg tgaccatgga ggatctcatg aaaactgatg    420
 ctgacactta ctggtgtgga attgagaaaa ctggaaatga ccttggggtc acagttcaag    480
 tgaccattga cccagcgtcg actcctgccc ccaccacgcc tacctccact acgtttacag    540
 caccagtcac ccaagaagaa actagcagct ccccaactct gaccggccac cacttggaca    600
 acaggcacaa gctcctgaag ctcagtgtcc tcctgcccct catcttcacc atattgctgc    660
 tgcttttggt ggccgcctca ctcttggctt ggaggatgat gaagtaccag cagaaagcag    720
 ccgggatgtc cccagagcag gtactgcagc ccctggaggg cgacctctgc tatgcagacc    780
 tgaccctgca gctggccgga acctccccgc aaaaggctac cacgaagctt tcctctgccc    840
 aggttgacca ggtggaagtg gaatatgtca ccatggcttc cttgccgaag gaggacattt    900
 cctatgcatc tctgaccttg ggtgctgagg atcaggaacc gacctactgc aacatgggcc    960
 acctcagtag ccacctcccc ggcaggggcc ctgaggagcc cacggaatac agcaccatca   1020
 gcaggcctta gcctgcactc caggctcctt cttggacccc aggctgtgag cacactcctg   1080
 cctcatcgac cgtctgcccc ctgctcccct catcaggacc aacccgggga ctggtgcctc   1140
 tgcctgatca gccagcattg cccctagctc tgggttgggc ttggggccaa gtctcagggg   1200
 gcttctagga gttggggttt tctaaacgtc ccctcctctc ctacatagtt gaggaggggg   1260
 ctagggatat gctctggggc tttcatggga atgatgaaga tgataatgag aaaaatgtta   1320
 tcattattat catgaagtac cattatcata atacaatgaa cctttattta ttgcctacca   1380
 catgttatgg gctgaataat ggcccccaaa gatatctgtg tcctaatcct cagaacttgt   1440
 gactgttacc ttctgtggca gaaagggaca gtgcagatgt atgtaagtta aggactttga   1500
 gatagagagg ttattcttgc tgattcaggt gggcccaaaa tatcaccaca agggtcctca   1560
 taagaaagag gccagaaggt caaagaggta gagacaaagt gatgatggaa gtggacgtgg   1620
 gtgtgacgtg agcaggggcc atgaatgccg cagccttcag atgccagaaa gggaaaggaa   1680
 tggattcccc tgcctggagc ctccaaaaga aaccagccct gcccacgcct tgacttgagc   1740
 ccattgaaac tgatcttgag ctcctggcct ccagaattgc aggagaataa atttgtgttg   1800
 tttttaatga gaaaaaaaaa a                                             1821



      <210> 1472
      <211> 1821
      <212> DNA
      <213> Homo sapiens


      <400> 1472
 tttcgtgagg aagttcaagg gcgagagtga gtaccagcag aaggctggga gtctgtagtt     60
 tgttcctgct gccaggctcc actgagggga acggggacct gtctgaagag aagatgcccc    120
 tgctgacact ctacctgctc ctcttctggc tctcaggcta ctccattgcc actcaaatca    180
 ccggtccaac aacagtgaat ggcttggagc ggggctcctt gaccgtgcag tgtgtttaca    240
 gatcaggctg ggagacctac ttgaagtggt ggtgtcgagg agctatttgg cgtgactgca    300
 agatccttgt taaaaccagt gggtcagagc aggaggtgaa gagggaccgg gtgtccatca    360
 aggacaatca gaaaaaccgc acgttcactg tgaccatgga ggatctcatg aaaactgatg    420
 ctgacactta ctggtgtgga attgagaaaa ctggaaatga ccttggggtc acagttcaag    480
 tgaccattga cccagcgtcg actcctgccc ccaccacgcc tacctccact acgtttacag    540
 caccagtcac ccaagaagaa actagcagct ccccaactct gaccggccac cacttggaca    600
 acaggcacaa gctcctgaag ctcagtgtcc tcctgcccct catcttcacc atattgctgc    660
 tgcttttggt ggccgcctca ctcttggctt ggaggatgat gaagtaccag cagaaagcag    720
 ccgggatgtc cccagagcag gtactgcagc ccctggaggg cgacctctgc tatgcagacc    780
 tgaccctgca gctggccgga acctccccgc aaaaggctac cacgaagctt tcctctgccc    840
 aggttgacca ggtggaagtg gaatatgtca ccatggcttc cttgccgaag gaggacattt    900
 cctatgcatc tctgaccttg ggtgctgagg atcaggaacc gacctactgc aacatgggcc    960
 acctcagtag ccacctcccc ggcaggggcc ctgaggagcc cacggaatac agcaccatca   1020
 gcaggcctta gcctgcactc caggctcctt cttggacccc aggctgtgag cacactcctg   1080
 cctcatcgac cgtctgcccc ctgctcccct catcaggacc aacccgggga ctggtgcctc   1140
 tgcctgatca gccagcattg cccctagctc tgggttgggc ttggggccaa gtctcagggg   1200
 gcttctagga gttggggttt tctaaacgtc ccctcctctc ctacatagtt gaggaggggg   1260
 ctagggatat gctctggggc tttcatggga atgatgaaga tgataatgag aaaaatgtta   1320
 tcattattat catgaagtac cattatcata atacaatgaa cctttattta ttgcctacca   1380
 catgttatgg gctgaataat ggcccccaaa gatatctgtg tcctaatcct cagaacttgt   1440
 gactgttacc ttctgtggca gaaagggaca gtgcagatgt atgtaagtta aggactttga   1500
 gatagagagg ttattcttgc tgattcaggt gggcccaaaa tatcaccaca agggtcctca   1560
 taagaaagag gccagaaggt caaagaggta gagacaaagt gatgatggaa gtggacgtgg   1620
 gtgtgacgtg agcaggggcc atgaatgccg cagccttcag atgccagaaa gggaaaggaa   1680
 tggattcccc tgcctggagc ctccaaaaga aaccagccct gcccacgcct tgacttgagc   1740
 ccattgaaac tgatcttgag ctcctggcct ccagaattgc aggagaataa atttgtgttg   1800
 tttttaatga gaaaaaaaaa a                                             1821



      <210> 1473
      <211> 6703
      <212> DNA
      <213> Homo sapiens


      <400> 1473
 attgattcta attagcacat tttgtgcctc agctagtagc tccccgttaa gctctgcctg     60
 gagagttttt ttttagattc catcctgctc ataaacactg ccacctcctc cctccttctc    120
 tctttacaaa tgttacaaca caatcagaaa tttcctcttt tctttccttc ctgcattttc    180
 agcaggttcc cttgcgtcag aagcccagga ggaaaactca aggttttctc acgatgagtc    240
 ggaggaggat atcgtgtaaa gatctgggcc atgctgactg ccaagggtgg ctgtataaga    300
 aaaaggaaaa gggaagtttc ctaagcaaca aatggaaaaa gttctgggtg atactgaagg    360
 ggtcgtcact gtactggtat agcaatcaaa tggcagagaa agctgatgga tttgtcaacc    420
 tgcctgattt cactgtggaa agagcatctg aatgcaagaa aaagcatgct tttaagatca    480
 gccatccaca gatcaagacc ttttattttg cagctgagaa tgtgcaggaa atgaacgtgt    540
 ggttaaataa acttggatcg gctgtaatcc atcaggaatc cactacaaag gatgaagaat    600
 gttacagtga aagtgaacag gaagatccag aaatagctgc ggagacacca ccccctcctc    660
 acgcttccca gactcagtct ttgactgcac agcaggcatc ttcatcctca cccagcctga    720
 gtggaacgtc gtattctttc tcttccctgg aaaatacagt gaagacaccc agcagttttc    780
 cttcctcctt atctaaagag agacaatcct tgcctgacac agttaacagt ttgtctgctg    840
 ctgaagatga gggacaacca ataacgtttg ctgtgcaagt tcattcacct gtaccctcag    900
 aggcaggcat ccacaaggcc ctggaaaaca gttttgtcac atcagaaagt ggatttttga    960
 actctttatc tagtgatgat acttcttcat tgagtagcaa tcatgaccat cttactgtcc   1020
 cagataagcc tgctggatca aagatcatgg acaaagaaga gacaaaagtg tctgaagatg   1080
 atgaaatgga gaagctgtac aaatcattag agcaagctag tctatctcct cttggggacc   1140
 gacgaccttc gactaaaaag gagttgagaa aatcctttgt taagcggtgt aaaaatccat   1200
 ctataaacga gaaactccac aaaatccgaa cattgaatag cacattaaag tgtaaagaac   1260
 atgatctggc catgattaac cagttgctgg atgacccgaa gctgacagcc aggaaataca   1320
 gagagtggaa agtcatgaac accctgctga tccaggacat ctatcagcag cagcgggctt   1380
 cgcctgcccc tgatgacact gatgacaccc cccaggaact caagaaatca ccttcttctc   1440
 cctctgttga aaattccatt tgagacaaag tcagggtttt ctcctcttat attttatcac   1500
 aagcaactct tcaagatgtt gcaaaagctt acatttttcc ttaaaaggaa aactgaaacc   1560
 cagtccttca agcatcagct tcccatctaa agatgcacgt tagatgaaga taatcaccga   1620
 atacaccagg gctcctcatt tcagtcgtaa cgcatccatt gagattggaa tgattgagtt   1680
 cagttgaaag gcgttttttg tgttcctact gggagctcac ggtgatgtgg ggctctaggg   1740
 gggatgtgag aaatgtctct tctgttcatt gctctccaga gaatgctatg gacaagaatc   1800
 aaattttacc aggagtaatt gcccatggaa acattctgtt tttcaaaaga agaatgtaca   1860
 tattccactt gactgggaag ctgtgtggcc caaatcactg tttgagtgga ggaatgtttt   1920
 ctagagcagt gactggaagg acaaacgtgg tgttgcagaa caaaaattcc ttgcctttgg   1980
 tatggaatgg tggtgccttt tccatgtgat gagaaatgct tcatagacag tggcatgtgg   2040
 gagagctgaa ggaggaggcg tgttccatat tccactcatt caaaggacag cttggtgttt   2100
 tcacacttta tgcaggttag gggatctgat taatgtttcc tttccttaca acagctagag   2160
 aaaacatctc atcacaattg gagacctcta cttcctttga gctttcctac tcaatggtag   2220
 gagataggaa tatgttccgc aaagaatgtc tactgctctt gtccttggct gtgatcccta   2280
 tacatagtgt gaatttatat ccaggtttcc caggatcaat attgacaaga cgactttggc   2340
 atctgaattg ttttaatatc tttactcaaa aaaacaaaaa aacaaaaacc catggaagca   2400
 acaaaagagt taaacatgag ggatttattt ttgtatgttt atatgtcact tgtgtgctat   2460
 gtgaatagct atgtttgtta tttaaatata tttatagaag ttcaaattac tagtgtttaa   2520
 aagatgatat actattatat attgtgctta gtatatattt gatgagtcta tactttttgc   2580
 ttgagaaaaa tagaaatact attgattcac tggtgttatg atgttgcact gtgtctgagg   2640
 aatgctcagg aaatcttgtg ggaaaaaaat ggggcatgca ttcataattt ttcattttct   2700
 tccccacccc aacccccatg agctcttaaa tttagatttc tatctcttgt aagtcactct   2760
 tttaaccagc aaaggacttt catcttagat tatcctttct attaaataaa ctttaagctt   2820
 tgtgccattt atgcctgcaa accttagacc aaaggcaaca caactaatgt catcttttca   2880
 ttaaagacta atagaaattt agaaatcatt gtgttaaaga gagctataga gaaacaatat   2940
 gaaagtcttc ccttactaat caccatgaat atttctcacc ataggaataa ccacaaccca   3000
 ccaagtaccc atgttggccc tgcctacccg taacaaattg ttcacacaac ctattttgtt   3060
 ttatagcttc aaagtgtggc ttgacattca aatggaagga accacctgaa ttatatctgc   3120
 aaacaaaatg gaaatagttg ttgaatagtt ccccaagctt tactaagaag ccttaatact   3180
 ctgtaaacaa acaaacaaac aaaaaacaac cttagcatta agaaataaaa acaaaaaaca   3240
 agaagcaagt tgtactgcta gaaacttctc taagataaga ggccaggcca gtcagtttgg   3300
 cccagcaaac atgtgggtac ttctccacct agggaagcca ctgaagatga gtttgacctg   3360
 tggtgacctg acagagagaa cattcagatc ctcagattgc accctgatgc cctggtttag   3420
 gaaagcagtg ctttaacctt ttgcccctgg aaattactga ttctttctgt gattagcaga   3480
 taccagaagg gaaattattt aggattggca atgtaaagag tattgaagga acaacaaata   3540
 acaatagcag aaataacagt gtgacataaa gtgcccttcc acctattttt ctttggtttg   3600
 caacaccagc ctgtagactt ccagtttttc ttaaattgaa gagctccaga cacttttgag   3660
 cagggtttgt gaatagcttt gaatgctttc ctttggcttt tcgtgaagac atatttcccc   3720
 agcctttcaa ctgtaaactc ctttagtacc attgaaactt aaggcaaaaa agatccctgg   3780
 gattacttag ccaaggctta aatttatttt tcaaagtcaa gaacattagc ctagaagttt   3840
 ttgctttgct agttaaagct tactttgcag agcttcccaa agtgaaaggg aaactgaact   3900
 tcacaatttt gcacctggct ttctggagcc ccattgcctg ctcattcgtg tttttccccc   3960
 tgtaaattat tttgcttttg accaggttgt gctagaaagt agggctgctt ctgtgagttc   4020
 tcagcctagg ctgtggccac taagacgtgg gtggggggat agacaggagt gagagggaga   4080
 gtgggtgaca ctttccgtga cacttaatgt aggaagacat gggcttctct ctcttggcct   4140
 caagccactt ttctggtcca aagaatattg ggaaaactgg attactttca gtatatttct   4200
 tgagaccggg tcatctctga aatgcatttg gggtagtttc ctgggggtcc aagggccaat   4260
 tcctataccc agtcctggca gtgtctgtga gctgtgggaa tgagagagaa aaccatgggc   4320
 ttgcttcagg gaagggaagt gggagaatct cttcagcaca cgtagatccc aaatctgtgg   4380
 gcacctgcta aagattagga tttggagagg actcctcttt ggggttgtga agaggacctt   4440
 ttccctctgt tgttagcctg tagatccaga acggagcctg atgtgatgcc ttcactggtt   4500
 gatatattgc aaatagacac tctgagccct gcattgcaag ggcgtctttt gctttaaaga   4560
 attcttagtt ttgccacaac agctcaaatc tcagaatagg atcaaaggcc tagaaagact   4620
 cctaaagtat aggattacaa agactccagg aagcgtaaga aagagattgt gtttggagtc   4680
 agatttcaat gtgaaaccca tgccttacat ttacacagca ctttgtagtt tgcaaattgg   4740
 tgtgttttca gccccctccc gctgccccat gctctgagat gattgtggat tattacagtg   4800
 aagtgcctgg cccggagccc ccagtgatga agcaggaact tgagtctcag gactcccagc   4860
 ggctctctgc ccattttctc ctctccgccc cccacctcgc ttcacctgtt accttgtgaa   4920
 gttgctgttg gcacatagcc cactaggaaa ccaagaagtt tgactgggag cgtgtgtttc   4980
 attgcactgg gcttagcata cggctggccc tggtggctgt ttgggcctaa attcccccat   5040
 ttgaaaccct aaagggcccc tcctccgtgc ttgagcacag tctccctccc tagtggccct   5100
 gcctcaacct gctggcgggc tgtctatgga ttggggtttc acctaatcat gctgtgtttc   5160
 ctttcttttc tttctgtaca ttagactact tgggaggtgc tgtgtgatcc ttggatgaaa   5220
 aacatatatt taaagaaatg gagagtgttt attttgtttg ctttttgagg catgtgctgt   5280
 caaatgttag agaccaaact tagtgattag aggttggtcc tttgaccttc ttctcttaat   5340
 tgcttttcat gtaatcatga taatttactc aggtagcact ccagtcacaa acaatgtcac   5400
 agagatgaaa cagattcaaa gaaaaaatat ttttaagtct tttgaaaaga agtgctattc   5460
 aaatttaaga catgtttaaa ttcataggta cattatctct tagtaagaaa tacttttttt   5520
 tttctttttt taaacagagt cttgctctgt tgcccaggct ggagtgcagt ggcacgattt   5580
 tagctcactg caacctctgc ctccctggtt gaagtgattc tcctgcctca gcctcccgag   5640
 tagctgggac tacccccggc taatttttat atttttagta gagaccgggg tttaccatgt   5700
 tgcccaggct ggtttcaaac tcctgacctc aggggatctg cctgcctctg cctcccaaag   5760
 ggctgggatt acagggggga gccaccacac ctggccgaaa gacagtattt tgatatagcc   5820
 acatacatga tttaatgagt aatgttaagt acagaaaagc tgccatatcc acatagtttt   5880
 agggggcatt tcttcttcag tctaacaaga atatggatat ccaattgtgg ttttccaatt   5940
 tatttctctt ccaatttctt ttgtatacct cacaggagaa attgaatcct aaaactggga   6000
 gatgactgcc ctgcccaggg ttttgtaata cataattgaa aataaaagtc cctgaaacta   6060
 aatgtttgca gcctgtatga aatggactgt ggaaggggga taatttctct cctcacagaa   6120
 agccactcgt ctccttgaat gaggcattga gcagacacac gtttctctgt gtcgtggggc   6180
 aggaagcaat tcccttgcct cttcagcaca tctcagttct ttcccacatg accccagaac   6240
 cacatagaaa acattgaaaa taatggattc ttcattgtat ttgaattttt tttttttaac   6300
 ctttagccca aaagggaagt gtgcctcgtg gaaagagcaa atgccgtaaa ataaaaacca   6360
 ggagttttaa tcgccatata ttttaatggg cttgcatgat gggaatgtga cttttagcac   6420
 tgcatggggt ttgggggcaa gatattaatg tggaaatctt agcttaagtt ttactgggct   6480
 ctcatcctgt gtcagctacc cctctaaact gaaaaagagg catggctcat ttctctcctg   6540
 ctttatgttt ttgaggttga cttgtaagat aaaaataaaa ataagaaaaa aatatatcta   6600
 ggcaaatgac atgaaaaaaa agttgaaata tactactggt gttcattttt gtcctgcagt   6660
 gttgctttct caaagaaata aacatgtggc tggaagtgtt taa                     6703



      <210> 1474
      <211> 631
      <212> DNA
      <213> Homo sapiens


      <400> 1474
 gtgtggtgga attcccggag aaggtgaaat tctgtgtgct ccctccggcg agagactttg     60
 tcagctcccg cacagtaaca tcctgaataa agtcaaaact caaccaacag gtggaagtcc    120
 aagaatccga gtggaggctc accgaggcga aggggccaac catgggaaag gagagtggat    180
 gggactcagg cagggctgct gtagcagctg tggtcggagg agttgtggct gtggggactg    240
 tgctcgtggc gctcagtgcc atgggcttca cctcagtagg aatcgccgca tcctccatag    300
 cagccaagat gatgtctaca gcagccattg ccaacggggg cggagttgct gctggcagtc    360
 tggtggctat tctgcagtca gtgggggcag ctggactctc tgtgacatct aaagttatcg    420
 ggggctttgc tgggacagct cttggggcct ggctgggttc acccccttcc agctgaacac    480
 cacactgagg cagggagttg gctctcttgg tggagatgac tttcctgggc ctctggatga    540
 caatcttcca aaggacaagt ctcctactcc caaaactatt taaggaagca tgaaaaataa    600
 agatgctggt tatcttctcc taaaaaaaaa a                                   631



      <210> 1475
      <211> 631
      <212> DNA
      <213> Homo sapiens


      <400> 1475
 gtgtggtgga attcccggag aaggtgaaat tctgtgtgct ccctccggcg agagactttg     60
 tcagctcccg cacagtaaca tcctgaataa agtcaaaact caaccaacag gtggaagtcc    120
 aagaatccga gtggaggctc accgaggcga aggggccaac catgggaaag gagagtggat    180
 gggactcagg cagggctgct gtagcagctg tggtcggagg agttgtggct gtggggactg    240
 tgctcgtggc gctcagtgcc atgggcttca cctcagtagg aatcgccgca tcctccatag    300
 cagccaagat gatgtctaca gcagccattg ccaacggggg cggagttgct gctggcagtc    360
 tggtggctat tctgcagtca gtgggggcag ctggactctc tgtgacatct aaagttatcg    420
 ggggctttgc tgggacagct cttggggcct ggctgggttc acccccttcc agctgaacac    480
 cacactgagg cagggagttg gctctcttgg tggagatgac tttcctgggc ctctggatga    540
 caatcttcca aaggacaagt ctcctactcc caaaactatt taaggaagca tgaaaaataa    600
 agatgctggt tatcttctcc taaaaaaaaa a                                   631



      <210> 1476
      <211> 987
      <212> DNA
      <213> Homo sapiens


      <400> 1476
 cgacccacgc gtccgggatg ttgttctctt ttccctgtct ttatttcctt accattcggc     60
 tgccatccgt tgagctgagg aagcctagag ctctcagaag cagtcctttg agctggtgta    120
 ggggcactca gaatggtcca gcgtttgaca taccgacgta ggctttccta caatacagcc    180
 tctaacaaaa ctaggctgtc ccgaacccct ggtaatagaa ttgtttacct ttataccaag    240
 aaggttggga aagcaccaaa atctgcatgt ggtgtgtgcc caggcagact tcgaggggtt    300
 cgtgctgtaa gacctaaagt tcttatgaga ttgtccaaaa caaagaaaca tgtcagcagg    360
 gcctatggtg gttccatgtg tgctaaatgt gttcgtgaca ggatcaagcg tgctttcctt    420
 atcgaggagc agaaaatcgt tgtgaaagtg ttgaaggcac aagcacagag tcagaaagct    480
 aaataaaaaa atgaaacttt tttgagtaat aaaaatgaaa agacgctgtc caatagaaaa    540
 agttggtgtg ctggagctac ctcacctcag cttgagagag ccagttgtgt gcatctcttt    600
 ccagttttgc atccagtgac gtctgcttgg catcttgaga ttgttatggt gagagtattt    660
 acacctcagc aaatgctgca aaatcctgtt ttcccccaga gagctggagg ttaaatacta    720
 ccagcacatc cctagatact actcaagtta cagtatatga tcactaatat agtatgctct    780
 tggtaccagg agctctgata tatatctggt acatgtttga taatgacttg attgttatta    840
 taagtactta ttaatacttc gattctgtaa agagtttagg gtttgatttt ataaaatcca    900
 aaatgagcct tttattgaat ccagttctct atgtgaccag ttctctgtat gaatggaagg    960
 gaaaagaatt aaaaatcttg caaaggg                                        987



      <210> 1477
      <211> 446
      <212> DNA
      <213> Homo sapiens


      <400> 1477
 atttcagaat atgacctgtg agctccatct gacttgctct gtggaggatg cagatgacaa     60
 tgtctcattc agatgggagg ccttgggaaa cacactttca agtcagccaa acctcactgt    120
 ctcctgggac cccaggattt ccagtgaaca ggactacacc tgcatagcag agaatgctgt    180
 cagtaattta tccttctctg tctctgccca gaagctttgc gaagatgtta aaattcaata    240
 tacagatacc aaaatgattc tgtttatggt ttctgggata tgcatagtct tcggtttcat    300
 catactgctg ttacttgttt tgaggaaaag aagagattcc ctatctttgt ctactcagcg    360
 aacacagggc cccgcagagt ccgcaaggaa cctagagtat gtttcagtgt ctccaacgaa    420
 caacactgtg tatgcttcag tcactc                                         446



      <210> 1478
      <211> 1841
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1841)
      <223> n = a,t,c or g


      <400> 1478
 tttttttttt ttatctgtat gaaatattag ttttaataaa acagaaccag tccatgtatg     60
 gaggcatggg cataaggtca acttgcacta aatgtaactc gtacgttttt tctaaaataa    120
 tttcttgagc attgtggtgg ccttatgtac taacccgaag ctgaacttcc tgggaagctg    180
 atccaatgga gcacttggaa ttcaggggtg gagtcttctt cctgggtcag agctggttca    240
 gggtcacatg ctcttgaggt ccctaaaggc cacatgtgct gcatttcgcc cagcagctcc    300
 catcacacct cctccaggat gagccccact tccacagaga tacaggccct ggagagggca    360
 gcggtagcca gaatgcaggg gcacggggcg ggcgaagtag agctggtcca gggacatggc    420
 gcagtggaat atgttccctc caggaagccc gaagattctc tccaaatctg gtggtgtgag    480
 gatgtctctg ccaaccacag agtccttgaa gccaggggca tagacctcga tgcaatcaaa    540
 cactgtggga aggcaggcca tccatggcat cttcaaaggc ctgatgaagg aggagggtgt    600
 cttcacagtt caggtggatg gagcattggt gatggggcag cggctggccc ctgggagcat    660
 tgggggccgc caggaagctg ggcagcctgt ctacggccac ttctgaccag gctgcagggg    720
 gacacaggct ggaggtccgg gaatggagat gatgactgag ttcagctgcc cccagcctgg    780
 aggtttctca ctcagatggg tcaaaggaga cagtgctgca atgtggtgtg cctcttacca    840
 ttgatcttgg tgacaggcga ccgggtgtcc agctgagaga ttctctccag gaactcctca    900
 ggaagccact cctgtggcgt cagcttcagg aaggtgatct gcggtgatgt gttggacagc    960
 accattttgc ttctcacctc tgtgccatct tccagcacaa ctccttgaac acagccttca   1020
 ctgttcacct gcaccttcgc cactgtcttt tcagtgaaga tgcttgctcc atgtgtggtg   1080
 gctgagcttg cgatcgcatc agagagggca cccatgcccc cctggacgta gccccaggcc   1140
 ccctgcattc cctccaggcc ccccatcaca tggtgcagca gcacatacct gtggacagac   1200
 catccgactc agatcctgga ggtgggatct catctcccca gagttccagg tgcaactatt   1260
 cctttccatc ttgatcttca gcccttccct gccaccatcc agccctctcc cagcagcctt   1320
 caatgagctc aagttcttgt aagagccctt tgccttctct acaccctctc cctaacaagt   1380
 gtgtctatgt gcatagctta ttaccacaaa gaaggcaacg atgcccaaac ctgcagctcc   1440
 agccctctcc tgagctccag ctccggtgtc cagctaccca cagatatctc cctttggacc   1500
 ctttcttggc agcatcttaa acccaccacc ttttccccat tctccagctg cttccccttc   1560
 aatctttccc atcccagtga acggcacctt tcaacaggag gttctgtttc cgacagaaat   1620
 ccaggtgtca gccttgaccg ctaccatcct tccccatcta catccacaaa gcaacaccaa   1680
 ctcagcctcc aaagggcttt caaggtcatc ccacctctca gccactcttc tcttcattat   1740
 gctgctgcag tagtgcccct cattggaccc cctctcccac gaattccncc gcnctgtcct   1800
 agagtcatca gtgagggnct catttnnccn ncgggggcgc g                       1841



      <210> 1479
      <211> 418
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(418)
      <223> n = a,t,c or g


      <400> 1479
 cccacgcgtc cgaaagaaag ttaagcaact acaggaaatg gctttgggag ttccaatatc     60
 agtctatctt ttattcaacg caatgacagc actgaccgaa gaggcagccg tgactgtaac    120
 acctccaatc acagcccagc aaggtaactg gacagttaac aaaacagaag ctgacaacat    180
 agaaggaccc atagccttga agttctcaca cctttgcctg gaagatcata acagttactg    240
 catcaacggt gcttgtgcat tccaccatga gctagagaaa gccatctgca ggtgttttac    300
 tggttatact ggagaaaggt gtctaaaatt gaaatcgcct tacaatgtct gttctggaga    360
 aagacgacca ctgtgaggcc tttgtgaaga attttcatca aggcatctgt agagatcn      418



      <210> 1480
      <211> 418
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(418)
      <223> n = a,t,c or g


      <400> 1480
 cccacgcgtc cgaaagaaag ttaagcaact acaggaaatg gctttgggag ttccaatatc     60
 agtctatctt ttattcaacg caatgacagc actgaccgaa gaggcagccg tgactgtaac    120
 acctccaatc acagcccagc aaggtaactg gacagttaac aaaacagaag ctgacaacat    180
 agaaggaccc atagccttga agttctcaca cctttgcctg gaagatcata acagttactg    240
 catcaacggt gcttgtgcat tccaccatga gctagagaaa gccatctgca ggtgttttac    300
 tggttatact ggagaaaggt gtctaaaatt gaaatcgcct tacaatgtct gttctggaga    360
 aagacgacca ctgtgaggcc tttgtgaaga attttcatca aggcatctgt agagatcn      418



      <210> 1481
      <211> 418
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(418)
      <223> n = a,t,c or g


      <400> 1481
 cccacgcgtc cgaaagaaag ttaagcaact acaggaaatg gctttgggag ttccaatatc     60
 agtctatctt ttattcaacg caatgacagc actgaccgaa gaggcagccg tgactgtaac    120
 acctccaatc acagcccagc aaggtaactg gacagttaac aaaacagaag ctgacaacat    180
 agaaggaccc atagccttga agttctcaca cctttgcctg gaagatcata acagttactg    240
 catcaacggt gcttgtgcat tccaccatga gctagagaaa gccatctgca ggtgttttac    300
 tggttatact ggagaaaggt gtctaaaatt gaaatcgcct tacaatgtct gttctggaga    360
 aagacgacca ctgtgaggcc tttgtgaaga attttcatca aggcatctgt agagatcn      418



      <210> 1482
      <211> 845
      <212> DNA
      <213> Homo sapiens


      <400> 1482
 atggcgcctc ctctgcgacc cctcgcccgg ctgcgaccgc cggggatgct gctccgcgcg     60
 ctcctgctcc tgctgctgct cagtcctttg ccagggctgc gagagggaat aggtgaactc    120
 ataaccccaa tcggcaccag cttgccggat ctggatccag ccaggaggag atgggagggt    180
 ggaattggca gggttggaag tgaagtggcc gatttgtgcc ccggaaagga ggggggaaaa    240
 gtccccgaag ctgaaaagga aggagtgtgg tgctttagcg aactgtcttt tgtaaaagaa    300
 ccacaggatg taactgtcac aagaaaggac ccagtcgttt tagattgcca ggctcacgga    360
 gaagttccta ttaaggtcac atggttgaaa aatggagcaa aaatgtctga aaataaacgg    420
 atcgaggttc tttctaacgg ctctttatac atcagtgagg tggaaggcag gcgaggagag    480
 cagtccgatg aaggatttta tcagtgcttg gcaatgaaca aatatctgag ccattcttaa    540
 ccaaaaagct catcttgcct tatcaaggat agggagtaca tagaggaggc ggccagatag    600
 gccatgagaa gacgaagcat ttgtcatgac cacacattgt ttccaagacc tcctgacaag    660
 cctgatagaa tcctagggct tccagaaaca cttttggaaa aacacagagc tttctaactt    720
 catacacaaa atgtgaatgg tgtgtgatag gtgtaacaaa caaaatgtca gaactggctc    780
 tttaaatatc tttagatatt tgcatctcta tagaaaggat tactaacaat aactatgtac    840
 atgcg                                                                845



      <210> 1483
      <211> 3147
      <212> DNA
      <213> Homo sapiens


      <400> 1483
 atggcaaaga tcagtgccag tagagcagag aaagttttgg agcatccagg agagagagag     60
 aagggcagag agatggcatc tccctggaat cattccatcc ttgccctggc agctgtggtg    120
 gtcattataa gcatggtcct cctgggaaga agcatccagg caagcagaaa agaaaagatg    180
 cagccaccag aaaaagaaac tccagaagtc ctgcatttgg atgaggccaa ggatcacaac    240
 agcctaaaca acctaagaga aactttgctc tcagaaaagc caaacttggc ccaggtggaa    300
 cttgagttaa aagagagaga tgtgctgtca gttttccttc cggatgtacc agaaactgag    360
 agctacatct ccgtcgtgaa catggccctg ccaccattct tcggccaggg tcgcccaggc    420
 ccaccgcccc cgcagccgcc gcctcttgct cttttcggct gtccgccacc gccgctgccc    480
 tccccggctt tcccgccgcc tctcccccag cggcccggcc cttttccggg ggcctccgcc    540
 cccttccttc agcctccgct ggctctgcag ccccgagcct ccgcgcaggc ctcccgcggc    600
 ggaggcggcg ctggcgcctt ctacccggtg ccaccaccgc cgctgcctcc tccgccgccc    660
 cagtgtcggc ccttcccggg gaccgacgcc ggcgagcggc cgcggccacc gcctcccggc    720
 ccggggccgc cctggagccc gcggtggcct gaggcgccgc cgccgccggc cgacgtgctc    780
 ggggatgcgg ccctccaacg cctgcgcgac cggcagtggc tggaggcggt gttcgggacc    840
 ccgcggcggg caggctgtcc ggtgccccag cgcacgcatg ccgggcccag ccttggcgaa    900
 gtgcgcgcgc gattgctccg ggctctgcgc ctggtgcggc ggctgcgcgg cctgagccag    960
 gccctgcgcg aggccgaagc cgacggcgcg gcctgggtcc tgctgtactc ccagaccgcg   1020
 ccgctgcgcg cggaactggc cgagcggcta cagccgttga cccaggctgc ctatgtgggc   1080
 gaggcgcgga ggaggctgga gagggtccgg cgccgccggc tgcggcttcg cgagagggcc   1140
 cgggaacgcg aggccgagcg ggaggcagag gccgcgcggg cagtggaacg cgagcaggag   1200
 attgaccgct ggagggtgaa gtgtgtgcag gaggtggagg agaagaagcg gtttttctgt   1260
 gagattctca cagatgaatt ggtgctgtgg gaaccatctg gcagacccca gccacaacag   1320
 ctgcaaatcc ttacagccat gtctaccagc actttctatg acaaggagct gaagacggca   1380
 agggaaaaca aagaagaaga gttaatcgac aaactggagg tggtcacaat gccttcccca   1440
 tcaccaaaag gactgccagt gaagcaatat gctgtgcagt ctcagcttcc cgtatatgag   1500
 tggccggatg tgggatctgg agaatatgat gttggagtag tggcttcgtt tggccgactt   1560
 ttgaatgagg ctcttattct taaatttccc tactccgcac ttggcggctc aggctccccg   1620
 gcgccactca ccagacttgc cagccccgcg gcgccccagg atggccaggt tgacctcgag   1680
 gggcgcgctc tgaggcccgc tgcccgcgcg gggttttcca aacaccgagg acatggcgac   1740
 gccctggacg gccacgcagg tctgcggccg gaactccatg ctccactgac tgttgttgca   1800
 gatgggcttt tctccaagtt caggaaaagc ctggtctcca ataaagtttc tgtatcatct   1860
 cattttgtcg gctttcttat gaagcacgac ttcagcctgg agaggacggc actcttctgg   1920
 gtggaggccg ccggccaggg acccagcccg taccagtgcg gtgacccggg gacagcgtca   1980
 gcccctccag cctggctctt gctagtcagc cccgaacatg ggctggcgcc tgcgcccacc   2040
 acaatcagag acccggaggc cggacaccag gagaggccgg aggaggaggg tgaggacgag   2100
 gcagaagcct cctctggcag cgaggaagag ccggccccca gcagcctcca accgggctcc   2160
 ccggcgagcc ccggccccgg ccgtcgcctg tgctcgctgg acgtgctacg cggcgtgcgg   2220
 ttggagctgg caggggcgcg gcggcggctc tccgagggga agctggtctc ccggccccgc   2280
 gccctcctgc atggcctccg cggccaccgc gcgctgagcc tgtgcccgag ccctgcgcag   2340
 tcccccaggt ctgcatcacc cccggggccc gcgccccagc accccgccgc ccccgcgtcg   2400
 cccccgcggc cctccacggc aggcgccatc cccccgctgc ggagccacaa gcctacggtc   2460
 gcgatataca taacaacaaa gcgcttaccc tattttccaa ttgtaaactt tctatttttg   2520
 atcgctcagt tgccaaaact tcaatacaac aaaaatgtgg ccctgaccgt gaagtttctg   2580
 accaagaggt ttatcagtga atatgacccc aacttgggaa tggtctgccg aaaaccgacc   2640
 gacccggttg attggccacc acttgtcctg ggactgctca ctttgatgaa gcagttccat   2700
 tcccggtaca ccgagcagtt cctggcgctg attggccagt ttatctgctc cacggtggag   2760
 cagtgtacaa ggcaagtcac caaggcagag ggtgtggctt tggcaggcag gtttgggtgc   2820
 ctgtttttcg aggtctctgc ctgtttggac tttgagcacg tgcagcatgt tttccacgag   2880
 gcagtgcgag aggcacggcg ggagctggag aagagccccc tgaccccccc cctcttcatc   2940
 tccgaggaga gggccctgcc ccaccaggcc ccgctcaccg cgcggcatgg gctggccagc   3000
 tgcaccttca acacgctctc caccatcaac ctgaaggaga tgcccactgt ggcccaggcc   3060
 aagctggtca ccgtgaagtc atcccgggcc cagagcaagc gcaaggcgcc taccctgact   3120
 ctcctgaagg gcttcaagat cttctga                                       3147



      <210> 1484
      <211> 911
      <212> DNA
      <213> Homo sapiens


      <400> 1484
 agcgcgccca tacatacgga ggctgtaaaa ccttgaggag attcatcttg caggctctcc     60
 ttccatcaag tctctcctcc ctagcgctct gggtccttaa tggcagcagc cgccgctacc    120
 aagatccttc tgtgcctccc gcttctgctc ctgctgtccg gctggtcccg ggctgggcga    180
 gccgaccctc actctctttg ctatgacatc accgtcatcc ctaagttcag acctggacca    240
 cggtggtgtg cggttcaagg ccaggtggat gaaaagactt ttcttcacta tgactgtggc    300
 aacaagacag tcacacctgt cagtcccctg gggaagaaac taaatgtcac aacggcctgg    360
 aaagcacaga acccagtact gagagaggtg gtggacatac ttacagagca actgcgtgac    420
 attcagctgg agaattacac acccaaggaa cccctcaccc tgcaggccag gatgtcttgt    480
 gagcagaaag ctgaaggaca cagcagtgga tcttggcagt tcagtttcga tgggcagatc    540
 ttcctcctct ttgactcaga gaagagaatg tggacaacgg ttcatcctgg agccagaaag    600
 atgaaagaaa agtgggagaa tgacaaggtt gtggccatgt ccttccatta cttctcaatg    660
 ggagactgta taggatggct tgaggacttc ttgatgggca tggacagcac cctggagcca    720
 agtgcaggag caccactcgc catgtcctca ggcacaaccc aactcagggc cacagccacc    780
 accctcatcc tttgctgcct cctcatcctc ctcccctgct tcatcctccc tggcatctga    840
 ggagagtcct ttagagtgac aggttaaagc tgataccaaa aggctcctgt gagcacggtc    900
 ttgatcaaac t                                                         911



      <210> 1485
      <211> 2843
      <212> DNA
      <213> Homo sapiens


      <400> 1485
 gtaagtgcgg tggaattcgt gctccatggg aaagatttcc aagtagattg caaagcttcc     60
 ggctccccag tgccttagat atcttggagt ttgcttgatg gaaccatgat caacaatgca    120
 atgcaagccg atgacagtgg ccacaggact aggagatata cccttttcaa caatggaact    180
 ttatacttca acaaagttgg ggtagcggag gaaggagatt atacttgcta tgcccagaac    240
 accctaggga aagatgaaat gaaggtccac ttaacagtta taacagctgc tccccggata    300
 aggcagagta acaaaaccaa caagagaatc aaagctggag acacagctgt ccttgactgt    360
 gaggtcactg gggatcccaa accaaaaata ttttggttgc tgccttccaa tgacatgatt    420
 tccttctcca ttgataggta cacatttcat gccaatgggt ctttgaccat caacaaagtg    480
 aaactgctcg attctggaga gtacgtatgt gtagcccgaa atcccagtgg ggatgacacc    540
 aaaatgtaca aactggatgt ggtctctaaa cctccattaa tcaatggtct gtatacaaat    600
 agaactgtta ttaaagccac agctgtgaga cattccaaaa aacactttga ctgcagagct    660
 gaagggacac catctcctga agtcatgtgg atcatgccag acaatatttt cctcacagcc    720
 ccatactatg gaagcagaat cacagtccat aaaaatggaa ccttggaaat taggaatgtg    780
 aggctttcag attcagccga ctttatctgt gtggcccgaa atgaaggtgg agagagcgtg    840
 ttggtagtac agttagaagt actggaaatg ctgagaagac cgacatttag aaatccattt    900
 aatgaaaaaa tagttgccca gctgggaaag tccacagcat tgaattgctc tgttgatggt    960
 aacccaccac ctgaaataat ctggatttta ccaaatggca cacgattttc caatggacca   1020
 caaagttatc agtatctgat agcaagcaat ggttctttta tcatttctaa aacaactcgg   1080
 gaggatgcag gaaaatatcg ctgtgcagct aggaataaag ttggctatat tgagaaatta   1140
 gtcatattag aaattggcca gaagccagtt attcttacct atgcaccagg gacagtaaaa   1200
 ggcatcagtg gagaatctct atcactgcat tgtgtgtctg atggaatccc taagccaaat   1260
 atcaaatgga ctatgccaag tggttatgta gtagacaggc ctcaaattaa tgggaaatac   1320
 atattgcatg acaatggcac cttagtcatt aaagaagcaa cagcttatga cagaggaaac   1380
 tatatctgta aggctcaaaa tagtgttggt catacactga ttactgttcc agtaatgatt   1440
 gtagcctacc ctccccgaat tacaaatcgt ccacccagga gtattgtcac caggacaggg   1500
 gcagcctttc agctccactg tgtggccttg ggagttccca agccagaaat cacgtgggag   1560
 atgcctgacc actcccttct ctcaacggca agtaaagaga ggacacatgg aagtgagcag   1620
 cttcacttac aaggtaccct agtcattcag aatccccaaa cctccgattc tgggatatac   1680
 aaatgcacag caaagaaccc acttggtagt gattatgcag caacgtatat tcaagtaatc   1740
 tgacatgaaa taataaagtc aacaacatct gggcagaatt tattttttgg aagaagttta   1800
 atcaaaggca gccataggca tgtaaatgaa tttgaataca tttacagtat taaatttaca   1860
 atgaacatgc aaaataaaag gacttgtaaa taaatgcatt atgaactgat gatactgatt   1920
 tatttaatgg atctcaaaac aaacttttaa cttaaggcac ttttattttg ccaacaaata   1980
 acaataaaca aacattgaaa cggttcacta taaaataaca aatggctaat gtacctgaat   2040
 ttttcagtaa aaaaatgaac ttctaatacc agttgcccta gtgtccacct cctatccaat   2100
 gttaccaagc atggcactcc agaaccagag accaatggaa aatattaaat ctggcaatct   2160
 ttatgatgta aatttaccat cctgatgtat aaatattttg tggtttataa atttttttgc   2220
 taaaacctac agaaaataag cactgaactg tcttatgatt caccatttgt tcacactgaa   2280
 aattttcatt gatggggaat acaaaaatgt tttaataact gcatttaaaa ataaatgcag   2340
 gctcactttt ccacatgtaa aaagcaatgt aatacctgca catcataaaa tgtgaaaagg   2400
 gggttatttt tgtccaaata cacccattaa aaaggtttta aaaatacaat gaaacttctt   2460
 tataacttta aaatctagct caggcacccc tggtttggag ctgtttataa ggaaattttt   2520
 ctgagcagga atcgttgctc tataagcatt tcatttcatt aattctttat gggatgggaa   2580
 aatgcttggg agggtctagg tctattatat ataatgaagt ttcactgtat ttaaaatctg   2640
 atcaatccta cacaaaatgt gtttttgtaa ttcactgaat ttatattaca tgcttaattc   2700
 aacctgaatt aatttgggga atattaaatg attgatctta tctaaatcta ggggtggggt   2760
 tttccagtgt aatttctcca gcatctattc aaacattcac ctagtactta cttacttaag   2820
 aattatagga gctttataaa tgg                                           2843



      <210> 1486
      <211> 2843
      <212> DNA
      <213> Homo sapiens


      <400> 1486
 gtaagtgcgg tggaattcgt gctccatggg aaagatttcc aagtagattg caaagcttcc     60
 ggctccccag tgccttagat atcttggagt ttgcttgatg gaaccatgat caacaatgca    120
 atgcaagccg atgacagtgg ccacaggact aggagatata cccttttcaa caatggaact    180
 ttatacttca acaaagttgg ggtagcggag gaaggagatt atacttgcta tgcccagaac    240
 accctaggga aagatgaaat gaaggtccac ttaacagtta taacagctgc tccccggata    300
 aggcagagta acaaaaccaa caagagaatc aaagctggag acacagctgt ccttgactgt    360
 gaggtcactg gggatcccaa accaaaaata ttttggttgc tgccttccaa tgacatgatt    420
 tccttctcca ttgataggta cacatttcat gccaatgggt ctttgaccat caacaaagtg    480
 aaactgctcg attctggaga gtacgtatgt gtagcccgaa atcccagtgg ggatgacacc    540
 aaaatgtaca aactggatgt ggtctctaaa cctccattaa tcaatggtct gtatacaaat    600
 agaactgtta ttaaagccac agctgtgaga cattccaaaa aacactttga ctgcagagct    660
 gaagggacac catctcctga agtcatgtgg atcatgccag acaatatttt cctcacagcc    720
 ccatactatg gaagcagaat cacagtccat aaaaatggaa ccttggaaat taggaatgtg    780
 aggctttcag attcagccga ctttatctgt gtggcccgaa atgaaggtgg agagagcgtg    840
 ttggtagtac agttagaagt actggaaatg ctgagaagac cgacatttag aaatccattt    900
 aatgaaaaaa tagttgccca gctgggaaag tccacagcat tgaattgctc tgttgatggt    960
 aacccaccac ctgaaataat ctggatttta ccaaatggca cacgattttc caatggacca   1020
 caaagttatc agtatctgat agcaagcaat ggttctttta tcatttctaa aacaactcgg   1080
 gaggatgcag gaaaatatcg ctgtgcagct aggaataaag ttggctatat tgagaaatta   1140
 gtcatattag aaattggcca gaagccagtt attcttacct atgcaccagg gacagtaaaa   1200
 ggcatcagtg gagaatctct atcactgcat tgtgtgtctg atggaatccc taagccaaat   1260
 atcaaatgga ctatgccaag tggttatgta gtagacaggc ctcaaattaa tgggaaatac   1320
 atattgcatg acaatggcac cttagtcatt aaagaagcaa cagcttatga cagaggaaac   1380
 tatatctgta aggctcaaaa tagtgttggt catacactga ttactgttcc agtaatgatt   1440
 gtagcctacc ctccccgaat tacaaatcgt ccacccagga gtattgtcac caggacaggg   1500
 gcagcctttc agctccactg tgtggccttg ggagttccca agccagaaat cacgtgggag   1560
 atgcctgacc actcccttct ctcaacggca agtaaagaga ggacacatgg aagtgagcag   1620
 cttcacttac aaggtaccct agtcattcag aatccccaaa cctccgattc tgggatatac   1680
 aaatgcacag caaagaaccc acttggtagt gattatgcag caacgtatat tcaagtaatc   1740
 tgacatgaaa taataaagtc aacaacatct gggcagaatt tattttttgg aagaagttta   1800
 atcaaaggca gccataggca tgtaaatgaa tttgaataca tttacagtat taaatttaca   1860
 atgaacatgc aaaataaaag gacttgtaaa taaatgcatt atgaactgat gatactgatt   1920
 tatttaatgg atctcaaaac aaacttttaa cttaaggcac ttttattttg ccaacaaata   1980
 acaataaaca aacattgaaa cggttcacta taaaataaca aatggctaat gtacctgaat   2040
 ttttcagtaa aaaaatgaac ttctaatacc agttgcccta gtgtccacct cctatccaat   2100
 gttaccaagc atggcactcc agaaccagag accaatggaa aatattaaat ctggcaatct   2160
 ttatgatgta aatttaccat cctgatgtat aaatattttg tggtttataa atttttttgc   2220
 taaaacctac agaaaataag cactgaactg tcttatgatt caccatttgt tcacactgaa   2280
 aattttcatt gatggggaat acaaaaatgt tttaataact gcatttaaaa ataaatgcag   2340
 gctcactttt ccacatgtaa aaagcaatgt aatacctgca catcataaaa tgtgaaaagg   2400
 gggttatttt tgtccaaata cacccattaa aaaggtttta aaaatacaat gaaacttctt   2460
 tataacttta aaatctagct caggcacccc tggtttggag ctgtttataa ggaaattttt   2520
 ctgagcagga atcgttgctc tataagcatt tcatttcatt aattctttat gggatgggaa   2580
 aatgcttggg agggtctagg tctattatat ataatgaagt ttcactgtat ttaaaatctg   2640
 atcaatccta cacaaaatgt gtttttgtaa ttcactgaat ttatattaca tgcttaattc   2700
 aacctgaatt aatttgggga atattaaatg attgatctta tctaaatcta ggggtggggt   2760
 tttccagtgt aatttctcca gcatctattc aaacattcac ctagtactta cttacttaag   2820
 aattatagga gctttataaa tgg                                           2843



      <210> 1487
      <211> 2843
      <212> DNA
      <213> Homo sapiens


      <400> 1487
 gtaagtgcgg tggaattcgt gctccatggg aaagatttcc aagtagattg caaagcttcc     60
 ggctccccag tgccttagat atcttggagt ttgcttgatg gaaccatgat caacaatgca    120
 atgcaagccg atgacagtgg ccacaggact aggagatata cccttttcaa caatggaact    180
 ttatacttca acaaagttgg ggtagcggag gaaggagatt atacttgcta tgcccagaac    240
 accctaggga aagatgaaat gaaggtccac ttaacagtta taacagctgc tccccggata    300
 aggcagagta acaaaaccaa caagagaatc aaagctggag acacagctgt ccttgactgt    360
 gaggtcactg gggatcccaa accaaaaata ttttggttgc tgccttccaa tgacatgatt    420
 tccttctcca ttgataggta cacatttcat gccaatgggt ctttgaccat caacaaagtg    480
 aaactgctcg attctggaga gtacgtatgt gtagcccgaa atcccagtgg ggatgacacc    540
 aaaatgtaca aactggatgt ggtctctaaa cctccattaa tcaatggtct gtatacaaat    600
 agaactgtta ttaaagccac agctgtgaga cattccaaaa aacactttga ctgcagagct    660
 gaagggacac catctcctga agtcatgtgg atcatgccag acaatatttt cctcacagcc    720
 ccatactatg gaagcagaat cacagtccat aaaaatggaa ccttggaaat taggaatgtg    780
 aggctttcag attcagccga ctttatctgt gtggcccgaa atgaaggtgg agagagcgtg    840
 ttggtagtac agttagaagt actggaaatg ctgagaagac cgacatttag aaatccattt    900
 aatgaaaaaa tagttgccca gctgggaaag tccacagcat tgaattgctc tgttgatggt    960
 aacccaccac ctgaaataat ctggatttta ccaaatggca cacgattttc caatggacca   1020
 caaagttatc agtatctgat agcaagcaat ggttctttta tcatttctaa aacaactcgg   1080
 gaggatgcag gaaaatatcg ctgtgcagct aggaataaag ttggctatat tgagaaatta   1140
 gtcatattag aaattggcca gaagccagtt attcttacct atgcaccagg gacagtaaaa   1200
 ggcatcagtg gagaatctct atcactgcat tgtgtgtctg atggaatccc taagccaaat   1260
 atcaaatgga ctatgccaag tggttatgta gtagacaggc ctcaaattaa tgggaaatac   1320
 atattgcatg acaatggcac cttagtcatt aaagaagcaa cagcttatga cagaggaaac   1380
 tatatctgta aggctcaaaa tagtgttggt catacactga ttactgttcc agtaatgatt   1440
 gtagcctacc ctccccgaat tacaaatcgt ccacccagga gtattgtcac caggacaggg   1500
 gcagcctttc agctccactg tgtggccttg ggagttccca agccagaaat cacgtgggag   1560
 atgcctgacc actcccttct ctcaacggca agtaaagaga ggacacatgg aagtgagcag   1620
 cttcacttac aaggtaccct agtcattcag aatccccaaa cctccgattc tgggatatac   1680
 aaatgcacag caaagaaccc acttggtagt gattatgcag caacgtatat tcaagtaatc   1740
 tgacatgaaa taataaagtc aacaacatct gggcagaatt tattttttgg aagaagttta   1800
 atcaaaggca gccataggca tgtaaatgaa tttgaataca tttacagtat taaatttaca   1860
 atgaacatgc aaaataaaag gacttgtaaa taaatgcatt atgaactgat gatactgatt   1920
 tatttaatgg atctcaaaac aaacttttaa cttaaggcac ttttattttg ccaacaaata   1980
 acaataaaca aacattgaaa cggttcacta taaaataaca aatggctaat gtacctgaat   2040
 ttttcagtaa aaaaatgaac ttctaatacc agttgcccta gtgtccacct cctatccaat   2100
 gttaccaagc atggcactcc agaaccagag accaatggaa aatattaaat ctggcaatct   2160
 ttatgatgta aatttaccat cctgatgtat aaatattttg tggtttataa atttttttgc   2220
 taaaacctac agaaaataag cactgaactg tcttatgatt caccatttgt tcacactgaa   2280
 aattttcatt gatggggaat acaaaaatgt tttaataact gcatttaaaa ataaatgcag   2340
 gctcactttt ccacatgtaa aaagcaatgt aatacctgca catcataaaa tgtgaaaagg   2400
 gggttatttt tgtccaaata cacccattaa aaaggtttta aaaatacaat gaaacttctt   2460
 tataacttta aaatctagct caggcacccc tggtttggag ctgtttataa ggaaattttt   2520
 ctgagcagga atcgttgctc tataagcatt tcatttcatt aattctttat gggatgggaa   2580
 aatgcttggg agggtctagg tctattatat ataatgaagt ttcactgtat ttaaaatctg   2640
 atcaatccta cacaaaatgt gtttttgtaa ttcactgaat ttatattaca tgcttaattc   2700
 aacctgaatt aatttgggga atattaaatg attgatctta tctaaatcta ggggtggggt   2760
 tttccagtgt aatttctcca gcatctattc aaacattcac ctagtactta cttacttaag   2820
 aattatagga gctttataaa tgg                                           2843



      <210> 1488
      <211> 397
      <212> DNA
      <213> Homo sapiens


      <400> 1488
 cccatgtgct caagactggc gctaaaagtt ttgagcttct caaaagtcta cagccaccgt     60
 ccagggagca tgtagctgct ggctccgggg acactttgcg ttcgggctgg gagcgtgctt    120
 tccacgacgg cgacacgctt ccctggattg gcagccacac tgccttccgg gtcactgcca    180
 tggaggagcc gcaatcagat cctagcgtcg agccccctct gagtcaggaa acattttcag    240
 acctatggaa actactttct gaaaacaacg ttctggtaag gacaacggtt gggctgggga    300
 cctggaaggc tggggggctg gagggctgag gacctggtcc tctgactgct cttttcaccc    360
 atctacagtc ccccttgccg tcccaagcaa tggatga                             397



      <210> 1489
      <211> 1859
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1859)
      <223> n = a,t,c or g


      <400> 1489
 acctggtgga attcggcctc cctcccctgt cttctcagag caggtaatgg caagcatggc     60
 tgccgtgctc acctgggctc tggctcttct ttcagcgttt tcggccaccc aggcacggaa    120
 aggcttctgg gactacttca gccagaccag cggggacaaa ggcagggtgg agcagatcca    180
 tcagcagaag atggctcgcg agcccgcgac cctgaaagac agccttgagc aagacctcaa    240
 caatatgaac aagttcctgg aaaagctgag gcctctgagt gggagcgagg ctcctcggct    300
 cccacaggac ccggtgggca tgcggcggca gctgcaggag gagttggagg aggtgaaggc    360
 tcgcctccag ccctacatgg cagaggcgca cgagctggtg ggctggaatt tggagggctt    420
 gcggcagcaa ctgaagccct acacgatgga tctgatggag caggtggccc tgcgcgtgca    480
 ggagctgcag gagcagttgc gcgtggtggg ggaagacacc aaggcccagt tgctgggggg    540
 cgtggacgag gcttgggctt tgctgcaggg actgcagagc cgcgtggtgc accacaccgg    600
 ccgcttcaaa gagctcttcc acccatacgc cgagagcctg gtgagcggca tcgggcgcca    660
 cgtgcaggag ctgcaccgca gtgtggctcc gcacgccccc gccagccccg cgcgcctcag    720
 tcgctgcgtg caggtgctct cccggaagct cacgctcaag gccaaggccc tgcacgcacg    780
 catccagcag aacctggacc agctgcgcga agagctcagc agagcctttg caggcactgg    840
 gactgaggaa ggggccggcc cggaccccca gatgctctcc gaggaggtgc gccagcgact    900
 tcaggctttc cgccaggaca cctacctgca gatagctgcc ttcactcgcg ccatcgacca    960
 ggagactgag gaggtccagc agcagctggc gccacctcca ccaggccaca gtgccttcgc   1020
 cccagagttt caacaaacag acagtggcaa ggttctgagc aagctgcagg cccgtctgga   1080
 tgacctgtgg gaagacatca ctcacagcct tcatgaccag ggccacagcc atctggggga   1140
 cccctgagga tctacctgcc caggcccatt cccagctcct tgtctgggga gccttggctc   1200
 tgagcctcta gcatggttca gtccttgaaa gtggcctgtt gggtggaggg tggaaggtcc   1260
 tgtgcaggac agggaggcca ccaaaggggc tgctgtctcc tgcacatcca gcctcctgcg   1320
 actccccaat ctggatgcat tacattcacc aggctttgca aacccagcct cccagtgctc   1380
 atttgggaat gctcatgagt tactccattc aagggtgagg gagtagggag ggagaggcac   1440
 catgcatgtg ggtgattatc tgcaagcctg tttgccgtga tgctggaagc ctgtgccact   1500
 acatcctgga gtttggctct agtcacttct ggctgcctgg tggccactgc tacagctggt   1560
 ccacagagag gagcacttgt ctccccaggg ctggcatggc agctatcagg ggaatagaag   1620
 ggagaaagag aatatcatgg ggagaacatg tgatggtgtg tgaatatccc tgctggctct   1680
 gatgctggtg ggtacgaaag gtgtgggctg ggataagaga gggcagagcc catgttttct   1740
 gacataactc tacacctana taagggactg aacccttcca actgcgggag ctccttaaac   1800
 ccttctgggg agcatactgg gggctcttcc ccatcttcag ccccttcctc tgggttccc    1859



      <210> 1490
      <211> 1859
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1859)
      <223> n = a,t,c or g


      <400> 1490
 acctggtgga attcggcctc cctcccctgt cttctcagag caggtaatgg caagcatggc     60
 tgccgtgctc acctgggctc tggctcttct ttcagcgttt tcggccaccc aggcacggaa    120
 aggcttctgg gactacttca gccagaccag cggggacaaa ggcagggtgg agcagatcca    180
 tcagcagaag atggctcgcg agcccgcgac cctgaaagac agccttgagc aagacctcaa    240
 caatatgaac aagttcctgg aaaagctgag gcctctgagt gggagcgagg ctcctcggct    300
 cccacaggac ccggtgggca tgcggcggca gctgcaggag gagttggagg aggtgaaggc    360
 tcgcctccag ccctacatgg cagaggcgca cgagctggtg ggctggaatt tggagggctt    420
 gcggcagcaa ctgaagccct acacgatgga tctgatggag caggtggccc tgcgcgtgca    480
 ggagctgcag gagcagttgc gcgtggtggg ggaagacacc aaggcccagt tgctgggggg    540
 cgtggacgag gcttgggctt tgctgcaggg actgcagagc cgcgtggtgc accacaccgg    600
 ccgcttcaaa gagctcttcc acccatacgc cgagagcctg gtgagcggca tcgggcgcca    660
 cgtgcaggag ctgcaccgca gtgtggctcc gcacgccccc gccagccccg cgcgcctcag    720
 tcgctgcgtg caggtgctct cccggaagct cacgctcaag gccaaggccc tgcacgcacg    780
 catccagcag aacctggacc agctgcgcga agagctcagc agagcctttg caggcactgg    840
 gactgaggaa ggggccggcc cggaccccca gatgctctcc gaggaggtgc gccagcgact    900
 tcaggctttc cgccaggaca cctacctgca gatagctgcc ttcactcgcg ccatcgacca    960
 ggagactgag gaggtccagc agcagctggc gccacctcca ccaggccaca gtgccttcgc   1020
 cccagagttt caacaaacag acagtggcaa ggttctgagc aagctgcagg cccgtctgga   1080
 tgacctgtgg gaagacatca ctcacagcct tcatgaccag ggccacagcc atctggggga   1140
 cccctgagga tctacctgcc caggcccatt cccagctcct tgtctgggga gccttggctc   1200
 tgagcctcta gcatggttca gtccttgaaa gtggcctgtt gggtggaggg tggaaggtcc   1260
 tgtgcaggac agggaggcca ccaaaggggc tgctgtctcc tgcacatcca gcctcctgcg   1320
 actccccaat ctggatgcat tacattcacc aggctttgca aacccagcct cccagtgctc   1380
 atttgggaat gctcatgagt tactccattc aagggtgagg gagtagggag ggagaggcac   1440
 catgcatgtg ggtgattatc tgcaagcctg tttgccgtga tgctggaagc ctgtgccact   1500
 acatcctgga gtttggctct agtcacttct ggctgcctgg tggccactgc tacagctggt   1560
 ccacagagag gagcacttgt ctccccaggg ctggcatggc agctatcagg ggaatagaag   1620
 ggagaaagag aatatcatgg ggagaacatg tgatggtgtg tgaatatccc tgctggctct   1680
 gatgctggtg ggtacgaaag gtgtgggctg ggataagaga gggcagagcc catgttttct   1740
 gacataactc tacacctana taagggactg aacccttcca actgcgggag ctccttaaac   1800
 ccttctgggg agcatactgg gggctcttcc ccatcttcag ccccttcctc tgggttccc    1859



      <210> 1491
      <211> 1588
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1588)
      <223> n = a,t,c or g


      <400> 1491
 tttttttttt ttgcatttca aatattttaa tagttttatt tcgcaaagag aagcctaaga     60
 atttttttaa aaacatttcc agagagaaca ctttatacca taaaataaac ttgtataatt    120
 tgggaggaca aatcatctca aatgtatatt tttgaattat gtgccaattt tataattagt    180
 acaaaaatga cagctgaaat attttaaaaa tgtaaaaacc agtccaggca acataactat    240
 accatcttgc tgtaaaagta cttatatcga attccgcaca aaatattttt gcaatatgct    300
 aaatttagtt cttcaagtca ctcttcactg ccggctggct tttccatttt ctgttgtctc    360
 catcccattt tcctctttaa gatgttgata tagttcagct ctgttattaa cagagttcaa    420
 acgtccagca aattcctgat gttttctgga attggcagta ttgattctat tactccacaa    480
 ggataataac gacactggcc cttttgattt ttccacttgt ggagtttcat ccatttcaac    540
 aaggggtttt ttgtttggag gttctgggga atcaggcgaa tcttttataa tctcagcttc    600
 agccaattct tcttttccac gctctaagat tccttttaat ctctctgagt cttgccaaga    660
 cttttcctgt tcataatctt tcactgcttt ctctgacttg tcctctttgt cttccctctt    720
 tcttcctcgt ttctttcgtt cttcctcttc tgggggtttg ctcctgcatg ccatcagaca    780
 ttccaagact ctttgatgtt tctctgagtt gttgatatgg gctctgacaa gggtttctaa    840
 ttcattccac atgatacggt attgttcatc tcttttaggg ccctttcctc ttgtaccaac    900
 tgtggaaata ggtagaggat cattttttct ttccatatca actaagttgt atattgtttt    960
 ttgacagttt aacacatctt cttctgtcag agattctttc acaataacac tggctaatgg   1020
 aactaccgct tgcatgttaa aaatggtggt ttgtgaaatg atcataggcc agtaacgggt   1080
 atgtttttct aactgatctt ttgctcgttc caaagggacc tcaagacttc catcgatttt   1140
 atatctgggg tctagaaaag gagttaatct gttttccctc ataaattcac caaaatccta   1200
 atgataacca aataagataa aattagaaac tatgtctaat gtttcagtat ggattacatg   1260
 tactagtctg tttccctgat gtcttctgtc ctgtgatgtg caacaaaaca ttttttctaa   1320
 cagtatccct taactccact acttttttat cctttctgaa cttgaaacct atcagccttt   1380
 atatgatgaa aatgaagaaa gcctcaaaca taaatgcatt catggtatgt tttccccacc   1440
 ttttgtaaaa accaaggaac actttttttc cccttctgta atttaacttt tctatcacac   1500
 acagataaaa gagtcagtta atcacattag aagacccatt tgcttatata aaaactacat   1560
 tgagcgnacg cgtgggcgga cgcgtggg                                      1588



      <210> 1492
      <211> 1927
      <212> DNA
      <213> Homo sapiens


      <400> 1492
 agcggtggaa ttcgatcatg gaacttgcac tgctgtgtgg gctggtggtg atggctggtg     60
 tgattccaat ccagggcggg atcctgaacc tgaacaagat ggtcaagcaa gtgactggga    120
 aaatgcccat cctctcctac tggccctacg gctgtcactg cggactaggt ggcagaggcc    180
 aacccaaaga tgccacggac tggtgctgcc agacccatga ctgctgctat gaccacctga    240
 agacccaggg gtgcggcatc tacaaggact attacagata caacttttcc caggggaaca    300
 tccactgctc tgacaaggga agctggtgtg agcagcagct gtgtgcctgt gacaaggagg    360
 tggccttctg cctgaagcgc aacctggaca cctaccagaa gcgactgcgt ttctactggc    420
 ggccccactg ccgggggcag acccctgggt gctagaagcc cacaccctct accctgttcc    480
 tcagcatgga gctctggcat ccccacctca gtatctaacc tgaaccagcc tggcttttca    540
 aacactccgg ggggaggtag tcccagcctc ccccggaacc ctctaccaat gccttctgac    600
 cttctgaagc tttccgaatc ctcccagttg aggcagtagc tgtgtcctct gagggtggat    660
 gggaatcttg ggagaagccc aagcaaggga gccctcagag gtggtgtttg gaccaaagca    720
 tcggggtggg ggaggggtct gccgctgtcc cccacctgct ggcccccttg tccttcctca    780
 ccccctccaa tatagtctcg gagctacaac cgcagcagcc actataaagg gcaatattga    840
 tctttctgtc catgtggctc tatcttttaa aacctcaagg ccctccactg tcctaagata    900
 aagcctctca taggcactgg ggaccctgca cagtctggcc atgtgaccct ctccccaggc    960
 aagctctgaa gtccctgcag gtggaggcca tgcctgtctt aaactcagtt gcatccctgg   1020
 tgcccaaagc aacaccagaa ccaagaagga gctccataaa tccttcttgg gtgaagccta   1080
 gacaaagccg ccaggtcttg tggctccagg caccagagcc ttgagtactt tctcctgcct   1140
 ccaggcattg gctcagggtg aattacaagg ggctactgaa tggctattac tttcatcacg   1200
 actgatcccc acctcctcag ggtcaaaggg ctactttctg gaagtctccc caggctgact   1260
 ccttctccct gactgcaagg gctcactccc tcctccaagc tcccacaatg cttcatggct   1320
 ctgccgctta cctagcttgg cctagagtgg caaatggaac ttctctgatc tcccccaact   1380
 agactggagc ccccgaagga tggagaccat gtctgtgcca tctctgtttc ccctgttttc   1440
 ccacatacta ggtgctcaat tcatgcctgt gaatggcgtg agcccataat ggatacacag   1500
 aggttgcagc agatggtgtg ggtacctcac ccagatatct tccaggccca aggcccctct   1560
 ccctgagtga ggccaggtgt tggcagccaa ctgctccaat ctgcctcctt cccctaaata   1620
 ctgccctggt ctagtgggag ctgccttccc cctgccccac ctctcccacc aagaggccac   1680
 ctgtcactca tggccaggag agtgacacca tggagggtac aattgccagc tcccccgtgt   1740
 ctgtgcagca ttgtctgggt tgaatgacac tctcaaattg ttcctgggat cgggctgagg   1800
 ccaggcctct cctggaacca cctctctgct tggtctgacc ccttggccta tccagttttc   1860
 ctggttccct cacaggtttc tccagaaagt actccctcag taaagcattt gcacaagaaa   1920
 aaaaaaa                                                             1927



      <210> 1493
      <211> 489
      <212> DNA
      <213> Homo sapiens


      <400> 1493
 tccagcacca ggaagagtgg ctctaggagg gagaggagcc cagggactga cccaagatgc     60
 cgttgactcc agagccgccc tctgggcgcg tggaggggcc ccccgcatgg gaagcagccc    120
 catggccctc actgccctgt gggccctgca tccccatcat gctggtcctg gccaccctgg    180
 ctgcgctctt catcctcacc accgctgtgt tggctgaacg cctgttccgc cgtgctctcc    240
 gcccagaccc cagccaccgt gcacccaccc tggtgtggcg cccaggagga gagctgtgga    300
 ttgagcccat gggcaccgcc cgagagcgct ctgaggactg gtatggctct gcggtccccc    360
 tgctgacaga tcgggcccct gagcctccca cccagcaact tgggccccca gaccgtactg    420
 gaggtcccag cccggagcac cttctggggg ccccagccct gggaggggag gccccccgcc    480
 acaggcctg                                                            489



      <210> 1494
      <211> 2044
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2044)
      <223> n = a,t,c or g


      <400> 1494
 tttttttttt ttaaactttt ataaccttaa agggttattt taaaataatc tatggactac     60
 cattttgccc tcattagctt cagcatggtg tgacttctct aataatatgc ttagattaag    120
 caaggaaaag atgcaaaacc acttcggggt taatcagtga aatatttttc ccttcgttgc    180
 ataccagata cccccggtgt tgcacgacta tttttattct gctaatttat ggacaagtgt    240
 taaacaggaa caaggaatta ttccaacaag ttatggcaac atgttgctta ttttcaaagt    300
 acagtttaat gtctaggtgc cagcctttga tatagctatt tttgtaagaa catcctcctg    360
 gactttgggt tagttaaatc taaacttatt taaggattaa gtaggataac gtgcattgat    420
 tttgctaaaa gaatcaaggt aataattact taagctgatt cctgagggtg ggtatgactt    480
 ccaagctgga actccatcct tgatcgggta gggatttttt aaatcccatt tttggtaaaa    540
 ctatttccca aggaaatttt aaggcccttt cacttcagga aagaaaaaag gttgttgggg    600
 ggctgaggca ctttaatttt cttgagcagg gaagggagtt tcttcccaaa cttcacccat    660
 ctggggatac tgggtgtttc ttttacagga ttcctccttt aatttctgtt gagtagccgg    720
 gatccttggg aggcatgtag gaagcccgct ggatcatcac gggatacttg aaatgctcat    780
 gcaggtggtc aacatactca cacaccctat tttcaaggct tgcagaaact gatatgtagt    840
 caaatataat caggtgctgc accagttcac agaggccaac tccaccagca tgggggcaaa    900
 caggaatttc aaactttttg gccatcagca atactgagag gttctcattg acactgccca    960
 gtctgcaact gtcaatctgg aggaactgca gggccttcgc ctgtaggagt tgcttaaata   1020
 tcactctatt gtggcaactg ttctccctgg tgcaaatgcc caattcccta aatgggacca   1080
 gtgccttgga aaatggtggc gtgccccaaa aatgtcaatc aaggggaggt tggctcctca   1140
 atccacaatg gcttgaactt ggccagcttg gacatccact ccaccgcctc aggcacatcc   1200
 cagcgctggt tggcatccat catcaaagtc ttttccggtc caatcatgtc tcggatgatt   1260
 tggcatcttc gcatgtcatc ctggagatca gcacccacct ttactttaaa cctggtccag   1320
 ccatccttca gcgcctgggc acagagctgc ttcaacgtgt catctgagta ccccagccag   1380
 gcgcacgatg tcgtgtaagc agggtatcct tgtgccagca tttgcttctc tctttctttt   1440
 ttaccaattt gacctttctg cagtatttct agggcatcct cctcagtcag gacatcagtg   1500
 atgtacctga aatctatgca ggataccagc atcctgggat ccatgtccac aagtaacttc   1560
 cagacaggct ttccctcctg cttggcccac aagtcccaca ccgcgtttag gacggccgct   1620
 gtcgccaggt gcaccacgcc cttttctgga ccaatccatc tgagctgccc atcacttgtg   1680
 agctgcctat agaagcctct gaagtcacca acaatgtcct tgaggtcctt gttgagcaca   1740
 tggtgggcga gggcattcac agcacagaca acaacttcag tgccttttcc cagagtgaag   1800
 gtaattccac accccttgat tccatcttct gcatcagttt ctatgacgac ataggcagcc   1860
 gagtagtcag ggtccgtgtg catggcgtcc gcgccgtggc ccccaagcga cgtggggaag   1920
 cgcacgtccc ggaccgagag ccgggagatc ctgccgcgca ccatggcccc tgcgccccgt   1980
 ggccgcggcc cccgtgcggt caggactggt ggaattacnc cgcactggac tagtgttcat   2040
 cgag                                                                2044



      <210> 1495
      <211> 467
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(467)
      <223> n = a,t,c or g


      <400> 1495
 gcgccgcctc ctgctcctcc cgctgctgct gccgctgccg ccctgagtca ctgcctgcgc     60
 antccggccg cctggctccc catactagtc gccgcacgtc agctaactgt tcagatgatg    120
 caaaatcctc agattcttgc agcccttcaa gaaagacttg atggtctggt agaaacacca    180
 acaggataca ttgaaagcct gcctagggta gttaaaagac gagtgaatgc tctcaaaaac    240
 ctgcaagtta aatgtgcaca gatagaagcc aaattctatg naggaagttc atgatcttna    300
 aaggaagtat gctgttctct atcagcctct atttgataag cgatttgaaa ttattaatgc    360
 aatttatgaa cctacggaag aagaatgtga atggaaacca gatgaagaag atgagatttc    420
 ggaggaattg aaagaaaagg ccaagattga agatgagaaa aaggatg                  467



      <210> 1496
      <211> 1404
      <212> DNA
      <213> Homo sapiens


      <400> 1496
 tttttttttt ttaaaaagag aaacctttat ttacaaccat gggagtccca caggagtaca     60
 caaaacacac aatgtgcaca cacacaaaat gaacctttta agtcaatacc atgcgtgctc    120
 ctggccgcgc gccacccctc agtgccctat ccgcaccacc atcacagtga cgttgtcggc    180
 cgagccccgc tgcaccgcct tgttggccag cctgttgcag gctgcttcgt agcgggcgtc    240
 ggctgcggac ttcccttccc gggtctggat cttttcatcc tcgagacagg acaagatgaa    300
 gttcacggct tcttctgggg taaagacctt gaagagccca tcacaggcca acaaaatgaa    360
 cctgtcattg ggggtcagct ggcagcgtct gatgtcgggc acagaggtga caccgcagcg    420
 cttgtactgc ccgtccccaa tggagcgtga cacctctagc acgcccaaaa cacgcccatc    480
 cctgacgttt cctccagcct tctgtatcct catccgctct tcatactgag ttggattatg    540
 ctctttgctg aggcttaagg ctgcatgttt ttgactctcc tcattataac gacacaagat    600
 tgcccgacta tctccgaggt tggcaatata aagaatgttg tctacagcca gaacacacgt    660
 ggcagtggac ccatctttcc aggcaggctt ctggctggaa gcttgtttaa ggaactcttc    720
 atcagtatgc ttgaaagtgt ccaaaaggca tctcttcacg gttttctcta cactgattac    780
 atctccttta ggaaattttc tgattaagtt ttgatgcaaa ttctgtgcag caaattttga    840
 ggctcgaatt cctccatgtc catcaaaaac agcaaaatat gaaacccgag taatgaggga    900
 cgatgggggc ctacactcct cggtgatgtc gttcaggatg acgtgggcat cctgcatctc    960
 ctccctctca cccttccgct cagccacata gcccttcaga ccaaagatca ccgaagaggc   1020
 tttacaaact ttcttttcca caagctcttc actgccattc ttctcttcct cggaggtttt   1080
 tctctttgct cctttccctt cagtctttac catctgggat attgatgtgg caagagaacc   1140
 tgaatcgcca ctgctagcgg gtgggagatc atcaaaaagc aaaggtcccc ctgatcctga   1200
 gtcagtactg ctggccggag ggaggtcatc aaagagcagg ggtcctttct gagcttcttt   1260
 cccggcagcc gggcgcggcg agcgctcggg ctccggcagg tccccgaaga ggtccatggc   1320
 ggaggctggg tggaggcggc agcagcgaca gacactcagc ccgcgagcag cggccgggct   1380
 ccacgaaatc gtcgacccgg gaat                                          1404



      <210> 1497
      <211> 541
      <212> DNA
      <213> Homo sapiens


      <400> 1497
 tttcgtgggc cactgtgtga acacagaagg tgggtttgtg tgcgagcgtg ggccgggcat     60
 gcgggtgtct gccgaccgcc acagctgcca agacactgac gaatgcctag ggactccctg    120
 tcagcagaga tgtaaaaaca gcattggcag ctacaagtgt tcctgtcgaa ctggcttcca    180
 ccttcatggc aaccggcact cctgtgtaga tacaccccaa ggattcctct ctgctcaccc    240
 attttcttgg ctgcctttgc tccccttgat gtaaacgagt gtcggaggcc attggagagg    300
 cgagtctgtc accattcctg ccacaacacc gggggcagct ttctatgcac atgccgacct    360
 ggcttcaggc tccgagctga ccgcgtgtcc tgtgaagctt tcccgaaagc cgagctggcc    420
 ccatttgcca tcctgcaacc ccggtgacac ccgtacaaga ggctactgtt gcttgctgag    480
 gccgcacggc ctgccctgtg cccaggacat agacctcctt ctggggctcc agggacatca    540
 g                                                                    541



      <210> 1498
      <211> 2735
      <212> DNA
      <213> Homo sapiens


      <400> 1498
 ttagattcag ctttgggaat ttgttccagg aactgcatca tccagcccaa aagcaaaaga     60
 ggaaaatgca taagccagga tacctaaatg ttcctttatt taaacttgaa aatgtgactg    120
 caaaaggagt caagaagttt agtactcaac acatttcttc tttgtagaaa taactgctca    180
 agaagataaa ttgttaccta acagttgatt gatgaatatg aaatcagagc aagaggggct    240
 aattagagaa attactagct agggctattt acccaaacca tctatccaga ctgtagacat    300
 agaatcacca gatggctagg atcctggtgc agctggttcc cctttttcct taccctgaat    360
 gtcattaagg atgcattgcc aaatgctgcc cctctggcct gatgactaca ctccatattg    420
 gtcacctgcc ttctttttcc tacagtcttc ctccagacag gcacgccata caaccgacta    480
 cacttgggct cactgaatga atcacattct tctgctgtgc ctcccagaga tttcatcaaa    540
 gcacccgcag tggccttctg gaggctcctc aaactctcca ctcaatgttt cctgaaagtg    600
 tcgtgtttct cacctctaga ttgttattct catcagttac atgtgggttt cacaaattta    660
 tttctcagaa tgcaagtctg tctcttatat cctcgggaaa cacaccttta tatcccagtt    720
 agtactgaca aaaattaaac tagggactgg ccaaaaacag tgcctttcct cactttaatc    780
 tcactaaagt agataagact caagttattt tgttcttgca atggcattga caaatgtttg    840
 caccaaaaac catgttgaag ttcattaagg aaactgtgat ccaagatcca aggtcaaaaa    900
 aacaaattca tcaattcagc acaccaccaa ctcacaggct aagcatctta ctgctaattc    960
 attgatgctg ccatttgtca agtgccaaat tgaattattg atttgtcaat aatttccttc   1020
 cgttggttac ttatatagta tattgcaatt cttgttgctg aagtcagcta cactttttct   1080
 atttgaaaaa caatttcttg catttgggat ttcaggtata gtgattgtta caaatatgaa   1140
 ggacttgaat taacagcaag ttttcaagta aaactttact tatgtataac tgaatgagtt   1200
 cttaaagaca tttactaaca attttccaca aactaaaaat ttataaaaca ataaataaaa   1260
 tagactttaa aaaaaagcgt gtcacacagc tgcttgtttt ttgtttgttt ctttgtttgt   1320
 tttttagtag tgaaatggtg aaaaatcaga caatggtcac agagttcctc ctactgggat   1380
 ttctcctggg cccaaggatt cagatgctcc tctttgggct cttctccctg ttctatgtct   1440
 tcaccctgct ggggaatggg accatcctgg ggctcatctc actggactcc agactccaca   1500
 cccccatgta cttcttcctc tcacacctgg ccgtcgtcaa catcgcctat gcctgcaaca   1560
 cagtgcccca gatgctggtg aacctcctgc atccagccaa gcccatctcc tttgctggct   1620
 gcatgacata gacctttctc tttttgagtt ttgcacatac tgaatgcctc ctgttggtgc   1680
 tgatgtccta cgatcggtac gtggccatct gccaccctct ccgatatttc atcatcatga   1740
 cctggaaagt ctgcatcact ctggccatca cttcctggac atgtggctcc ctcctggcta   1800
 tggtccatgt gagcctcatc ctaagactgc ccttttgtgg gcctcgtgaa atcaaccact   1860
 tcttctgtga aatcctgtct gtcctcaggc tggcctgtgc tgatacctgg ctcaaccagg   1920
 tggtcatctt tgcagcctgc atgttcatcc tggtgggacc actctgcctg gtgctggtct   1980
 cctactcaca catcctggcg gccatcctga ggatccagtc tggggagggc cgcagaaagg   2040
 ccttctccac ctgctcctcc cacctctgcg tagtgggact cttctttggc agcgccatcg   2100
 tcatgtacat ggcccctaag tcccgccatc ctgaggagca gcagaaggtc ctttttctat   2160
 tttacagttc tttcaacccg atgctaaacc ccctgattta caacctgagg aatgtagagg   2220
 tcaagggtgc cctgaggaga gcactgtgca aggaaagtca ttcctaagag gtgtgacatt   2280
 tgaactgcca gcctcagttg tcacgtggac tcttgatgcc caattattgc ctcaatccag   2340
 aaaagtttac ttctctttat ctgtgcttta ctgacagaag ggcaagtctt ctctcgtttt   2400
 ttgcagataa aattttagat gtgttgcatt cattgggttt ctatgagatg tggttttatc   2460
 agacaatttt ttcttttatt tcacaattac tttaatatct ttgaccagca aatatctcca   2520
 ccctccaggg agaggtagta gcttctaggg aaaccatctt ggagagggtc ctgtcttccc   2580
 ctgaggtggg ctttgaatcc agcactcttc cccttggagg gtcacttgga accagctaac   2640
 ttttcagggt cctttcttcc cagttctgct catacatctg tcatgtaaca ctttagtgtt   2700
 ctatatttgc atagctgtat ccttccatta gtttg                              2735



      <210> 1499
      <211> 2735
      <212> DNA
      <213> Homo sapiens


      <400> 1499
 ttagattcag ctttgggaat ttgttccagg aactgcatca tccagcccaa aagcaaaaga     60
 ggaaaatgca taagccagga tacctaaatg ttcctttatt taaacttgaa aatgtgactg    120
 caaaaggagt caagaagttt agtactcaac acatttcttc tttgtagaaa taactgctca    180
 agaagataaa ttgttaccta acagttgatt gatgaatatg aaatcagagc aagaggggct    240
 aattagagaa attactagct agggctattt acccaaacca tctatccaga ctgtagacat    300
 agaatcacca gatggctagg atcctggtgc agctggttcc cctttttcct taccctgaat    360
 gtcattaagg atgcattgcc aaatgctgcc cctctggcct gatgactaca ctccatattg    420
 gtcacctgcc ttctttttcc tacagtcttc ctccagacag gcacgccata caaccgacta    480
 cacttgggct cactgaatga atcacattct tctgctgtgc ctcccagaga tttcatcaaa    540
 gcacccgcag tggccttctg gaggctcctc aaactctcca ctcaatgttt cctgaaagtg    600
 tcgtgtttct cacctctaga ttgttattct catcagttac atgtgggttt cacaaattta    660
 tttctcagaa tgcaagtctg tctcttatat cctcgggaaa cacaccttta tatcccagtt    720
 agtactgaca aaaattaaac tagggactgg ccaaaaacag tgcctttcct cactttaatc    780
 tcactaaagt agataagact caagttattt tgttcttgca atggcattga caaatgtttg    840
 caccaaaaac catgttgaag ttcattaagg aaactgtgat ccaagatcca aggtcaaaaa    900
 aacaaattca tcaattcagc acaccaccaa ctcacaggct aagcatctta ctgctaattc    960
 attgatgctg ccatttgtca agtgccaaat tgaattattg atttgtcaat aatttccttc   1020
 cgttggttac ttatatagta tattgcaatt cttgttgctg aagtcagcta cactttttct   1080
 atttgaaaaa caatttcttg catttgggat ttcaggtata gtgattgtta caaatatgaa   1140
 ggacttgaat taacagcaag ttttcaagta aaactttact tatgtataac tgaatgagtt   1200
 cttaaagaca tttactaaca attttccaca aactaaaaat ttataaaaca ataaataaaa   1260
 tagactttaa aaaaaagcgt gtcacacagc tgcttgtttt ttgtttgttt ctttgtttgt   1320
 tttttagtag tgaaatggtg aaaaatcaga caatggtcac agagttcctc ctactgggat   1380
 ttctcctggg cccaaggatt cagatgctcc tctttgggct cttctccctg ttctatgtct   1440
 tcaccctgct ggggaatggg accatcctgg ggctcatctc actggactcc agactccaca   1500
 cccccatgta cttcttcctc tcacacctgg ccgtcgtcaa catcgcctat gcctgcaaca   1560
 cagtgcccca gatgctggtg aacctcctgc atccagccaa gcccatctcc tttgctggct   1620
 gcatgacata gacctttctc tttttgagtt ttgcacatac tgaatgcctc ctgttggtgc   1680
 tgatgtccta cgatcggtac gtggccatct gccaccctct ccgatatttc atcatcatga   1740
 cctggaaagt ctgcatcact ctggccatca cttcctggac atgtggctcc ctcctggcta   1800
 tggtccatgt gagcctcatc ctaagactgc ccttttgtgg gcctcgtgaa atcaaccact   1860
 tcttctgtga aatcctgtct gtcctcaggc tggcctgtgc tgatacctgg ctcaaccagg   1920
 tggtcatctt tgcagcctgc atgttcatcc tggtgggacc actctgcctg gtgctggtct   1980
 cctactcaca catcctggcg gccatcctga ggatccagtc tggggagggc cgcagaaagg   2040
 ccttctccac ctgctcctcc cacctctgcg tagtgggact cttctttggc agcgccatcg   2100
 tcatgtacat ggcccctaag tcccgccatc ctgaggagca gcagaaggtc ctttttctat   2160
 tttacagttc tttcaacccg atgctaaacc ccctgattta caacctgagg aatgtagagg   2220
 tcaagggtgc cctgaggaga gcactgtgca aggaaagtca ttcctaagag gtgtgacatt   2280
 tgaactgcca gcctcagttg tcacgtggac tcttgatgcc caattattgc ctcaatccag   2340
 aaaagtttac ttctctttat ctgtgcttta ctgacagaag ggcaagtctt ctctcgtttt   2400
 ttgcagataa aattttagat gtgttgcatt cattgggttt ctatgagatg tggttttatc   2460
 agacaatttt ttcttttatt tcacaattac tttaatatct ttgaccagca aatatctcca   2520
 ccctccaggg agaggtagta gcttctaggg aaaccatctt ggagagggtc ctgtcttccc   2580
 ctgaggtggg ctttgaatcc agcactcttc cccttggagg gtcacttgga accagctaac   2640
 ttttcagggt cctttcttcc cagttctgct catacatctg tcatgtaaca ctttagtgtt   2700
 ctatatttgc atagctgtat ccttccatta gtttg                              2735



      <210> 1500
      <211> 394
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(394)
      <223> n = a,t,c or g


      <400> 1500
 gtccggattg atcaagagcc gcctgtccag tgttatgtag gggcaacggg cagtactcca     60
 agggccgttg cctgtgtttc agcggctgta agggcaccga gtgtgatgtg ccgactaccc    120
 agtgtattga cccacagtgc gggggacgtg ggatttgtat catgggctct tgtgcttgca    180
 actcaggata caaaggagaa agttgtgaag aagcaccaag atacattcca gagaaggaaa    240
 gnnnnnnnnn nnnggcctcc aacttgcatg tttaggagaa atggccggac atagcctacc    300
 aaagtggtgg ttcttcggga ttttttggac aaggggggta actaggaact tttctttttt    360
 actaaaacac tgaggttcgg ggggtttatt ttga                                394



      <210> 1501
      <211> 770
      <212> DNA
      <213> Homo sapiens


      <400> 1501
 tgaagggaga ccggctcggt ctctctctct cccagtggac tagaaggagc agagagttat     60
 gctgtttctc ccattcttta cagctcaccg gatgtaaaag aactctggct agagaccctc    120
 caaggacaga ggcacagcca cacgggagtg aaatccaccc ctggacagtc agccgcaata    180
 ctgatgaagc tgagaagcag ccacaatgct tcaaaaacac taaacgccaa taatatggag    240
 acactaatcg aatgtcaatc agagggtgat atcaaggaac atcccctgtt ggcatcatgt    300
 gagagtgaag acagtatttg ccagctcatt gaagttaaga agagaaagaa ggtgctgtcc    360
 tggccctttc tcatgagaag gctctcccct gcatcagatt tttctggggc tttggagaca    420
 gacttgaaag catcgctatt tgatcagccc ttgtcaatta tctgcggtga cagtgacaca    480
 ctccccagac ccatccagga cattctcact attctatgcc ttaaaggccc ttcaacggaa    540
 gggatattca ggagagcagc caacgagaaa gcccgtaagg agctgaagga ggagctcaac    600
 tctggggatg cggtggatct ggagaggctc cccgtgcacc tcctcgctgt ggtctttaag    660
 gacttcctca gaagtatccc ccggaagcta ctttcaagcg acctctttga ggagtggatg    720
 ggtgctctgg agatgcagga cgaggaggac agaatcgagg ccctgaaaca               770



      <210> 1502
      <211> 900
      <212> DNA
      <213> Homo sapiens


      <400> 1502
 ctaatacgtt gcatgcccgc gtaaacttgg gcccccccag ggatccttta aaacggccgc     60
 cccttttttt tttttttttt tctcaaatgt catttattag aaaatacaat tcccgagaaa    120
 ggagatacaa gggattctgg gaagtgggaa gtaaacagta cacagatctc tttaaatcag    180
 gagcatatag gtcataataa aatgagctac aggcacaaag ccagtaacac atttatggtc    240
 cgttcatctg gaaaagtttc accgcccact ccccactcct cttccccctc ctggaagcag    300
 ccagctttat ccttggcatt ttaattttag agaaaattta aacttccatg ctgccctgtg    360
 gcttcggtca atggagcttc tttctccagt tatggaatga gtcagcaaaa cggggagttt    420
 ctgatccttg gaattaggga gggacagttt acagaatgtc ctcatttcac tcttttccca    480
 atcatgggaa atatccagcc aattctggtt ttaaagattc atatcaaatt caaagtccct    540
 ccctcctttt ggcgaggaag acaacccttt agagcgaaac acaaaagagc aaatgtaaaa    600
 tccatctggg gcggggcatg gtggctcacg cctgtaatcc cagcactttg ggaggccaag    660
 gcaggcagat cacgaggtca agagatcgag accatcctgg ccaacatggt gaaaccccgt    720
 ctctactaaa aatacaaaaa ttagcttggc gtggtagcac atgcctgtaa tccccagcta    780
 ctcgggaggc tgaggtagga gaatcgcttg aacccgggag gcagattttg cagtgagtcg    840
 agatcatgcc actacactcc agcctggcga cagggcgaga ctccgtttcc aaaaaaaaaa    900



      <210> 1503
      <211> 900
      <212> DNA
      <213> Homo sapiens


      <400> 1503
 ctaatacgtt gcatgcccgc gtaaacttgg gcccccccag ggatccttta aaacggccgc     60
 cccttttttt tttttttttt tctcaaatgt catttattag aaaatacaat tcccgagaaa    120
 ggagatacaa gggattctgg gaagtgggaa gtaaacagta cacagatctc tttaaatcag    180
 gagcatatag gtcataataa aatgagctac aggcacaaag ccagtaacac atttatggtc    240
 cgttcatctg gaaaagtttc accgcccact ccccactcct cttccccctc ctggaagcag    300
 ccagctttat ccttggcatt ttaattttag agaaaattta aacttccatg ctgccctgtg    360
 gcttcggtca atggagcttc tttctccagt tatggaatga gtcagcaaaa cggggagttt    420
 ctgatccttg gaattaggga gggacagttt acagaatgtc ctcatttcac tcttttccca    480
 atcatgggaa atatccagcc aattctggtt ttaaagattc atatcaaatt caaagtccct    540
 ccctcctttt ggcgaggaag acaacccttt agagcgaaac acaaaagagc aaatgtaaaa    600
 tccatctggg gcggggcatg gtggctcacg cctgtaatcc cagcactttg ggaggccaag    660
 gcaggcagat cacgaggtca agagatcgag accatcctgg ccaacatggt gaaaccccgt    720
 ctctactaaa aatacaaaaa ttagcttggc gtggtagcac atgcctgtaa tccccagcta    780
 ctcgggaggc tgaggtagga gaatcgcttg aacccgggag gcagattttg cagtgagtcg    840
 agatcatgcc actacactcc agcctggcga cagggcgaga ctccgtttcc aaaaaaaaaa    900



      <210> 1504
      <211> 600
      <212> DNA
      <213> Homo sapiens


      <400> 1504
 ctccgcgctg caggaattcg gcacgagtgg cagacacatt ctacaccaat gctggctgca     60
 ccctggtagc cttgaacccc ttcaagcctg ttcctcagct ctactcgccc gagctaatga    120
 gagagtacca tgctgcgcct cagccccaga aactgaagcc ccacgtgttc actgtgggtg    180
 aacagaccta caggaatgtc aagagcctga ttgaaccagt caaccagtct attgttgtca    240
 gtggagagag tggtgctgga aagacatgga cgtctcgctg cctaatgaag ttctatgctg    300
 tggtggccac ctcacctgca tcttgggaga gccacaagat tgcagagagg atagaacaga    360
 ggatcctgaa ctccaaccct gtcatggaag cttttgggaa tgcgtgtaca ctgaggaata    420
 acaacagcag tcgctttggg aagttcatcc agctccagct gaacagggct cagcaaatga    480
 ctggagccgc agtccagacc tacctcctag agaaaactcg agtggcctgc caggcttcca    540
 gtgagaggaa caaggaccct atcccacctg agctgaccag gctcctgcag caatcccagg    600



      <210> 1505
      <211> 600
      <212> DNA
      <213> Homo sapiens


      <400> 1505
 ctccgcgctg caggaattcg gcacgagtgg cagacacatt ctacaccaat gctggctgca     60
 ccctggtagc cttgaacccc ttcaagcctg ttcctcagct ctactcgccc gagctaatga    120
 gagagtacca tgctgcgcct cagccccaga aactgaagcc ccacgtgttc actgtgggtg    180
 aacagaccta caggaatgtc aagagcctga ttgaaccagt caaccagtct attgttgtca    240
 gtggagagag tggtgctgga aagacatgga cgtctcgctg cctaatgaag ttctatgctg    300
 tggtggccac ctcacctgca tcttgggaga gccacaagat tgcagagagg atagaacaga    360
 ggatcctgaa ctccaaccct gtcatggaag cttttgggaa tgcgtgtaca ctgaggaata    420
 acaacagcag tcgctttggg aagttcatcc agctccagct gaacagggct cagcaaatga    480
 ctggagccgc agtccagacc tacctcctag agaaaactcg agtggcctgc caggcttcca    540
 gtgagaggaa caaggaccct atcccacctg agctgaccag gctcctgcag caatcccagg    600



      <210> 1506
      <211> 435
      <212> DNA
      <213> Homo sapiens


      <400> 1506
 caatggtaat ttaagtggct cttaaaaagt catgcaatat gtttctggac acgttcctga     60
 tcctattgcg ataatgtatg tgtgccctcc ctgtgggcac accacctggg cattaggact    120
 gaaattcctg agttcttcct ctcaaaattt ctgtgcacca gtattattcc tcattttaca    180
 tacaggaggc aactaagact catacagggc tcaactgaat aagaggctta agaggataaa    240
 ctggagcaga aataagcctt aggtgctgcc cagtttacac ttcctgggat ggatgttttt    300
 gtttgttttg ttttttgttt tttttgtttg agatggagtc tcactctgtc acctaggcta    360
 gagtgcagtg gtgtgatctc ggttcactgc aacctctgcc tcttgggttc aagcaattct    420
 catgccttgg cctcg                                                     435



      <210> 1507
      <211> 3923
      <212> DNA
      <213> Homo sapiens


      <400> 1507
 tttcgtgcag ggagaccact tagaggctgc tgctctagcg caggctcagg gcactagggg     60
 cttgggccag agtggtgatg ccagaggcga gaagatgctg ctgagttctg gctatgtttt    120
 gccctggacc catccaagga cccctgcctg aaggtaaaat gcagccctca caaagtgtgt    180
 gtgacccagg actaccagac cgccctgtgt gtcagccgca agcacctgct ccccaggcaa    240
 aagaagggga acgtggccca gaaacactgg gttggacctt cgaatttggt caagtgcaag    300
 ccctgtcccg tggcacagtc agccatggtc tgcggctcag atggccactc ctacacatcc    360
 aagtgcaaat tggagttcca tgcttgttct actggcaaaa gcctcgccac cctctgtgat    420
 ggggccctgt ccctgtctcc cagagcctgg agccaccaaa gcacaagggc agaaagggag    480
 tgccttgcac agacaaggag ttgcggaacc ttgcctcccg gctgaaggat tggtttggag    540
 ctctccacga ggatgcgaac agagtcatca agcccaccag ctccaacaca gcccaaggca    600
 ggtttgacac tagcatcctg cccatctgca aggactccct gggctggatg ttgaacaagt    660
 tggacatgaa ctatgacctc ctgcttgacc cttcagagat caatgccatc tacctggata    720
 agtacgagcc ctgtatcaag cctcttttca actcgtgtga ctccttcaag gatggcaaac    780
 ctttcctaaa caatgaatgg tgcctactgc cttcccagaa ccctggaggt ctccccttgc    840
 ccagaatgaa atgaacagaa ttcaagaagc tgagtaaggg gaaaagcctg ttgggggcct    900
 tcatacctcg gtgtaatgag gagggctatt acaaagccac acagtgccac ggcagcacgg    960
 ggcagtgctg gtgtgtggac aaatatggga atgagttggc tggctccagg aaacagggtg   1020
 ctgtgagctg tgaagaggag caggaaacct caggggattt tggcagtggt gggtccgtgg   1080
 tcctgctgga tgacctagaa tatgaacggg agctgggacc aaaggacaaa gaggggaagc   1140
 tgagggtgca cacccgagcc gtgacagagg atgatgagga tgaggatgat gacaaagagg   1200
 atgaggtcgg gtacatatgg tagtgcccac aagaaagagg acacaagttt tgcacaaaat   1260
 tgcaagtcac ttcctattcc tgcatttgta tctaagactc caaggcacca aggtcttttt   1320
 tccattgttg ctctctatac ccgacctaag gtttggaaga caactgcttg ttcccagagg   1380
 attctgattt tgcatatgtt tgtatgggaa aaagggtgtt gtgttttttt ttttgttgtt   1440
 gtttattttt tggataggga agtcattggc ttaattagag cctccttcct ttctgtgaga   1500
 tttttccaac aagcatgtga tttacgtgga attctgacag tgcagggagc ccccaccctc   1560
 ttaaatgtca aagacccttt ttgattaccc acactggtgg ttattacagc atggttccca   1620
 gccttacagt gtctaagtgc ttctcttgtg tcctgtagat gttgtgaaaa agaaaaaaac   1680
 aaaaaataca ccacactgta ctttttcccc ctgcccccgt tactgccggt gattattatt   1740
 aaaaattagt ttttttcaca tcattatatc tggcttccta taaacaacag ccttaattca   1800
 gtcaagactc cctttgggga attcatttta ttaaaaattg gtgtctggat acttccctgt   1860
 acatgcataa atatgcatgc atgtacagaa agactgtatg tgtgtgcctt gcacacacac   1920
 ccatacctct cagaaaaagt gggtatctta aaaactcgaa aaacaatgat aaatttctca   1980
 gcttgtccag acctggaaca aaatttctgg aataagaaat ttgtattaaa gtcctttttt   2040
 gcactaacag ttggctcttg tagcctgcag gctgaggaag tctcttctct gtgcatcagc   2100
 agagttactg aaagcctctg attgagaaaa aacctccgtc tgcctaaatc acttttctcg   2160
 cagaagccat gcgactccca cacgacacgg gcagcttcac aagccatctc tttcatttct   2220
 gcttgaagcc cccttggctg cagcaatcct gtctggccat aggtttcttc cttccttacc   2280
 tacttcaagg ggctttttct aagggcatgg cacacatatc ttcctgtttc tctggaggag   2340
 taccatgggg ttccttaaaa gaagaaaatt tctaattctg aactcaatgt tttgctttta   2400
 ctccctttct actgacaaat catgataagg gcacaaaagc tgtacagatt ttttttttta   2460
 accactcaat cccaaatgga ggcctacaaa gaacatcgta ataacacatg gaagcaaacc   2520
 ctgggttttt aagagccaaa ttctgtcccc cccctccact ccccccaagt gacaagatac   2580
 taatgaagaa agttcttcac catagtgttt gttttaacta aactcattgg agtctagttc   2640
 caaatttggg tagggtcatc atctctacat tccttaggat ttctctccct atcaagctgg   2700
 cccagataca agtaccaaac agtagtctct gaagttcccc catttccttc agtaccagtc   2760
 tataagctac tgtccgccac tgattttcat ctatcagggt gtcctaatca gaatcagcca   2820
 cccaagcaag cctctctggc ccacatatct atctcttgcc ttcccccatg aacttcagcc   2880
 tgtccacaca aaagccacat aaactcaagc aagaaatatg ttcagccaaa acatgattat   2940
 agtggcagct gaccaatccc ccatcccaaa ttgaccattt agatgtacca actcacctta   3000
 aattagcatg ttccaatcca gtcggcattg cctgaataca gtagcatcat acctatagtt   3060
 ggtcttagat aagaaatgaa ctacttgata tagcaaagtc ctttggcttc gtaaataacc   3120
 ctgaggtttt gtacttactt tccccatagg aagacagacc ataggcaaac tctgttttgg   3180
 gatctcaact ccatcacctt tgtttcaata ttttttttct ctcttgaaca aaactgagat   3240
 aatttagaaa acaggtgctt aattgcaata aaattactat gaagtatatt aaaaatcacg   3300
 acattgtaaa atctcacttt agatcatcaa agaaaaccat tgttactatc tcctttgagc   3360
 ttaggaaaat gtacaagaga acaaattaaa attgaaaaat tgatttcact tagaaaaact   3420
 tctaggaaca gggtgaacca ctgattttaa tttgcctaat tatcttatga caagtatcaa   3480
 attaagatga cacttaaaga tccttagcat taacttaatg atggagaaga gtgctcaaca   3540
 gacagttccc agtaaggtaa tgagatgcca ttttcagaga cattctaaga agatattttg   3600
 attcattaaa acattaaata aaaagccctc ctcagattgg aacccccaaa tcgatggagc   3660
 cacattaata atacttttca tgcctcactt tgacatgaca gcattcgatt tttttaaaga   3720
 tctttaatac tttccatgag tactaaagat tgtaatgagt taccttatcc ttagaagtag   3780
 aatgtttgct ttcttcttct tggaaatggt cctccaaaaa gtccacttgt accagtgaca   3840
 agaagtcact tgtatagtga ccaagtacac ataaaatact gattataaaa atattgtaat   3900
 aaaccacttc ctcatttgat acg                                           3923



      <210> 1508
      <211> 859
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(859)
      <223> n = a,t,c or g


      <400> 1508
 tcctcctggg ctggggctcg ctgctcatca tgctcaagtc agagggcttt tactcctacc     60
 tgtgtaccga gccagagaat gtcaccaatg gcacagtggg cggcacagca gagccggggc    120
 acgaggaggt gagctggatg aacggctggc tcagctgcca ggcccaggac gagatgctaa    180
 atttggcctt cactgtgggc tcctttctgc tcagtgccat caccctgccc ctgggtatcg    240
 tcatggacaa gtatggcccg aggaagctca ggctgctggg cagcgcctgc ttcgcggttt    300
 cctgcttgct gattgcgtac ggagcaagta aaccaaacgc tctctccgtg ctcatcttca    360
 tcgccctggc tctgaatggc tttggtggga tgtgtatgac cttcacctca ttaacactgc    420
 ccaacatgtt cggcgacctt cggttcacgt ttattgcctt gatgattggg tcctacgcct    480
 cctcggcagt cacctttcca ggaatcaagc tcatctatga tgctggtgtc tccttcatcg    540
 tcgtcctcgt ggtctgggcc ggctgctccg ggctggtttt cctcaactgc ttctttaact    600
 ggccccttga gcccttcccg gggccggagg acatggacta ctcggtgaag atcaagttca    660
 gctggctggg ctttgaccac aagatcacag ggaagcagtt ctacaagcag gtgaccacgg    720
 tgggccggcg cctgagtgtg ggcagctcca tgaggagtgc caaggagcag gtggcgctgc    780
 aggagggcca caagctgtgc ctgtccaccg tcgaccggaa ttccgngcgg tcggangcct    840
 tagtttcagg ttatcccca                                                 859



      <210> 1509
      <211> 859
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(859)
      <223> n = a,t,c or g


      <400> 1509
 tcctcctggg ctggggctcg ctgctcatca tgctcaagtc agagggcttt tactcctacc     60
 tgtgtaccga gccagagaat gtcaccaatg gcacagtggg cggcacagca gagccggggc    120
 acgaggaggt gagctggatg aacggctggc tcagctgcca ggcccaggac gagatgctaa    180
 atttggcctt cactgtgggc tcctttctgc tcagtgccat caccctgccc ctgggtatcg    240
 tcatggacaa gtatggcccg aggaagctca ggctgctggg cagcgcctgc ttcgcggttt    300
 cctgcttgct gattgcgtac ggagcaagta aaccaaacgc tctctccgtg ctcatcttca    360
 tcgccctggc tctgaatggc tttggtggga tgtgtatgac cttcacctca ttaacactgc    420
 ccaacatgtt cggcgacctt cggttcacgt ttattgcctt gatgattggg tcctacgcct    480
 cctcggcagt cacctttcca ggaatcaagc tcatctatga tgctggtgtc tccttcatcg    540
 tcgtcctcgt ggtctgggcc ggctgctccg ggctggtttt cctcaactgc ttctttaact    600
 ggccccttga gcccttcccg gggccggagg acatggacta ctcggtgaag atcaagttca    660
 gctggctggg ctttgaccac aagatcacag ggaagcagtt ctacaagcag gtgaccacgg    720
 tgggccggcg cctgagtgtg ggcagctcca tgaggagtgc caaggagcag gtggcgctgc    780
 aggagggcca caagctgtgc ctgtccaccg tcgaccggaa ttccgngcgg tcggangcct    840
 tagtttcagg ttatcccca                                                 859



      <210> 1510
      <211> 822
      <212> DNA
      <213> Homo sapiens


      <400> 1510
 tacgcagcct tcggtgcagt cgtcactcgt gtctcgctac cagctccccg ctgccctgcg     60
 ctcggcgggc tggcatccgg cccgggggaa agcggaccag cccttctgca ggtctgcggg    120
 gccaagtgtc ccggcggcgc acctcgtggc gagaatcggg agaaggagga gactacaagg    180
 ataggcccag gagtaatgga gtccaaagag aaacgagcag taaacagtct cagcatggaa    240
 aatgccaacc aagaaaatga agaaaaggag caagttgcta ataaagggga gcccttggcc    300
 ctccctttgg atgctggtga atactgtgtg cctagaggaa atcgtaggcg gttccgcgtt    360
 aggcagccca tcctgcagta tagatgggat atgatgcata ggcttggaga accacaggca    420
 aggatgagag aagagaatat ggaaaggatt ggggaggagg tgagacagct gatggaaaag    480
 ctgagggaaa agcagttgag tcatagtctg cgggcagtca gcactgaccc ccctcaccat    540
 gaccatcatg atgagttttg ccttatgccc tgaatcctga tggtttccct aaagttatta    600
 cggaaacaga cccctgcttt cgaatttaca tgttcatgat gtgcccttgt tgtaaacctt    660
 tacctgtcac ttgtttacgt gggtctccta ttaccagctt ctaattgaat attgtgtttt    720
 tgaaccagtc tgtaagattt ttgttagcag aagaatttta cctattgcat ggaaagatgc    780
 tcattatagt gaagttaata aagcaccttt aaaaagcaaa aa                       822



      <210> 1511
      <211> 1146
      <212> DNA
      <213> Homo sapiens


      <400> 1511
 taaaaagaaa acctttactg aatcagctga gtgttaataa tacgaatttc cttttcttgc     60
 caattctgat ctgaacagaa aatccaagaa cagggatatg tgtggattac agttttctct    120
 gccttgccta cgactgtttc tgccttgcat ccaagggtcc ttaagccgtt gtcttcattg    180
 attcatcttc aggcaaattc taatccttgg gaatgtaact gcaaactttt gggccttcga    240
 gactggctag catcttcagc cattactcta aacatctatt ggcagaatcc cccatccatg    300
 cgtggcagag cattacgtta tattaacatt acaaattgtg ttacatcttc aataaatgta    360
 tccagagctt gggctgttgt aaaatctcct catattcatc acaagactac tgcgctaatg    420
 atggcctggc ataaagtaac cacaaatggc agtcctctgg aaaatactga gactgagaac    480
 attactttct gggaacgaat tcctacttca cctgctggta gattttttca agagaatgcc    540
 tttggtaatc cattagagac tacagcagtg ttacctgtgc aaatacaact tactacttct    600
 gttaccttga acttggaaaa aaacagtgct ctaccgaatg atgctgcttc aatgtcaggg    660
 aaaacatctc taatttgtac acaagaagtt gagaagttga atgaggcttt tgacattttg    720
 ctagcttttt tcatcttagc ttgtgtttta atcatttttt tgatctacaa agttgttcag    780
 tttaaacaaa aactaaaggc atcagaaaac tcaagggaaa atagacttga atactacagc    840
 ttttatcagt cagcaaggta taatgtaact gcctcaattt gtaacacttc cccaaattct    900
 ctagaaagtc ctggcttgga gcagattcga cttcataaac aaattgttcc tgaaaatgag    960
 gcacaggtca ttctttttga acattctgct ttataactca actaaatatt gtctataaga   1020
 aacttcagtg ccatggacat gatttaaact gaaacctcct tatataatta tatactttag   1080
 ttggaaatat aatgaattat atgaggttag cattattaaa atatgttttt aataataaaa   1140
 aaaaaa                                                              1146



      <210> 1512
      <211> 348
      <212> DNA
      <213> Homo sapiens


      <400> 1512
 ttttacttaa atctatttat tgaaaaggtc acaataaata gaatgccact accacttgtc     60
 ctaaacaata aagtagccaa taaaaatata ccattaaaac aaaaacagtg ctaaaaaagt    120
 ctggaatttt ttccacctgc cctaagccca agtcctgcta tgattttgtg ccacttaatg    180
 caggccccat accacctaaa agtatcttgg gaaccaacgg acccacccac actttggaaa    240
 tgctggacta acgtctcaac aaacccaccc ctatcagccc tcagaggtca ccgctgactc    300
 aggtgggaca caggtagaca aggccaacca ggaggaggcc acgaacac                 348



      <210> 1513
      <211> 1439
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1439)
      <223> n = a,t,c or g


      <400> 1513
 cccacgcgtc cgcccacgcg tccgcccacg cgtccgctct tccagaccga ggagcaggga     60
 cccgagcccc aggagggcgc ggctaaggtg gcagctgcgc tggaaaccaa ggtggtgccc    120
 gagaccccca aagacaccag gtgtgtggaa gcggccaagg acgcgtcctc ggtcaagcgc    180
 aggaggctca accggattcc catcgagccc catcctaagg aggagcccaa gcacccggag    240
 aaggagcagc aggaaggcgt ccccaacagc gacgagggct actgggactc caccacgcca    300
 ggcccagagg aagacagctc gagcagcggg aagaaggcgg gcatcccccg ggatagctac    360
 agcggggacg cgctctatga tctctatgct gacccggacg gaagcccagc aacccttcct    420
 gggagggaag gacaaacgag gagacgtcct ccctgtcccg gttaaagccc gtatctccag    480
 gcaccatcac ctgtccactg cgaacaccag gcagcttgct gaaggactct aagatcccta    540
 ttagcatcaa gcacctgacc aaccttccat ctagccatcc cgtggtgcac cagcaaccct    600
 ccaggagtga gatgcccaga acaaaaatcc cggtttccaa agtgctggtc cgcagagtca    660
 gcaaccgggg cttggctggg accaccatca gagcaacggc ctgccacgac agtgcccaaa    720
 aagttgtgag gtcttccagg ccaaggtgga tgggccccat gccaaggaat acaacttttc    780
 cctgggaaac cactaaagta agttttgctt ttcctaaaga aagtctttta ggacaccacc    840
 cgtcccacgc cctgctccag agcgtggacc gaggaggtct ttgtgccctg agtagggacc    900
 ggataacacc agaaagaggg atgctacacg ggggtttctc ctctcaagat aagtccctga    960
 gaattatttt caagcacttt tttctttttt acctttaagt ttttcttcct tttgctttaa   1020
 tatactgaac acttgggaag tcacctttac ttgcctttgc agaaaacaga acttaggcca   1080
 aacctaagta aggagtcatg cctgggatat tggggataag ccagtgtcta ggagggcctg   1140
 gaagggaacc gctggaagga accaggaggg aggatctcct ntttcccaag gacacgtttc   1200
 cttccttccc ttctttcctc tttcctttcc agttaaaaaa aaacaaaaac aaaaacaaaa   1260
 ccctttgctg tatcactgtg tggaaaatac ctccaaagct gaaagagcca ggtatttacc   1320
 tgatgagcag aggggaccac tgattggcag aaaacttccc tacgttcagt tgttagatat   1380
 gcaaattgat aaggatctaa cactaggaaa ataaaggcga gttttggttt ggttggttt    1439



      <210> 1514
      <211> 435
      <212> DNA
      <213> Homo sapiens


      <400> 1514
 ccgggtcgac ccacgcgtcc ggtgagactg tttgcccttc catgtccttc ttaaatgctc     60
 atagactgag ctttgtagtt aatgttggtt ttgttgccca ggagcaaagc catgcctttg    120
 ctttcagtga atgtaactct agcatttttt cccaggaata aggaaattgt gaaatatctg    180
 ctaaaccaag gggccgatgt cactcttcgt gcaaaaaatg gatacacggc ctttgacctg    240
 gtgatgctgc tgaatgatcc cgacatattt gggggtgagt tgattggttt tttgtcggtg    300
 gtcacggaac ttgttcgact gctggcatct gtcttcatgc aggtgaataa ggacataggc    360
 cggcggagcc accagcttcc cttgccccac tcgaaggtcc cgacagcctt ggagcatccc    420
 agtgctgccc gatga                                                     435



      <210> 1515
      <211> 2193
      <212> DNA
      <213> Homo sapiens


      <400> 1515
 cctagttgag gctaacagtc agtatccagc ctcaacattc agcagaggcc ccagatcagc     60
 gtctgagcca ggccaacaat gaccaaggag gatgggatcc tgggtgcagc tcatcacaag    120
 cgtcggggtg cagcaaaacc atccaggctg gacagtggct ggacagttcc aagaaaagaa    180
 acgcttcact gaagaagtca ttgaatactt ccagaagaaa gttagcccag tgcatctgaa    240
 aatcctgctg actagcgatg aagcctggaa gagattcgtg cgtgtggctg aattgcccag    300
 ggaagaagca gatgctctct atgaagctct gaagaatctt acaccatatg tggctattga    360
 ggacaaagac atgcagcaaa aagaacagca gtttagggag tggtttttga aagagtttcc    420
 tcaaatcaga tggaagattc aggagtccat agaaaggctt cgtgtcattg caaatgagat    480
 tgaaaaggtc cacagaggct gcgtcatcgc caatgtggtg tctggctcca ctggcatcct    540
 gtctgtcatt ggcgttatgt tggcaccatt tacagcaggg ctgagcctga gcattactgc    600
 agctggggta gggctgggaa tagcatctgc cacggctggg atcgcctcca gcatcgtgga    660
 gaacacatac acaaggtcag cagaactcac agccagcagg ctgactgcaa ccagcactga    720
 ccaattggag gcattaaggg acattctgca tgacatcaca cccaatgtgc tttcctttgc    780
 acttgatttt gacgaagcca caaaaatgat tgcgaatgat gtccatacac tcaggagatc    840
 taaagccact gttggacgcc ctttgattgc ttggcgatat gtacctataa atgttgttga    900
 gacactgaga acacgtgggg cccccacccg gatagtgaga aaagtagccc ggaacctggg    960
 caaggccact tcaggtgtcc tcgttgtgct ggatgtagtc aaccttgtgc aagactcact   1020
 ggacttgcac aagggggaaa aatccgagtc tgctgagttg ctgaggcagt gggctcagga   1080
 gctggaggag aatctcaatg agctcaccca tatccatcag agtctaaaag caggctaggc   1140
 ccaattgttg cgggaagtca gggaccccaa acggagggac tggctgaagc catggcagaa   1200
 gaacgtggat tgtgaagatt tcatggacat ttattagttc cccaaattaa tacttttata   1260
 atttcctatg cctgtcttta ccgcaatctc taaacacaaa ttgtgaagat ttcatggaca   1320
 cttatcactt ccccaatcaa tacccttgtg atttcttatg cctgtcttta ctttaatctc   1380
 ctaatcctgt cagctgagga ggatgtatgt cacctcagga ccatgtgata attgcgttaa   1440
 ctgcacaaat tgtagagcat gtgtgtttga acaatatgaa atctgggcac cttgaaaaaa   1500
 gaacaggata acagcaattg ttcagggaat aagagagata accttaaact ctgaccaaca   1560
 gtgagccggg tggaacagag tcatatttct cttctttcaa aagcaaatgg gagaaatatc   1620
 gctgaattct ttttctcagc aaggaacatc cctgagaaag agaatgcacc cctgagggtg   1680
 ggtctataaa tggcctcctt gggtgtggcc attttctatg gtcggagact gtagggatga   1740
 aataaacccc agtctcccat agtgctccca ggcttattag aaagagggaa attcccgcct   1800
 aataaatttt ggtcagaccc ggttgctctc aaaaccctgt ctcctgataa gatgttatca   1860
 atgacaatgg tgcccgaaac ctcatttagc aatttttaat ttctccccgg tcctgtggtc   1920
 ctgtgatctc gccctgccgt ccacttgcct tgtgatattc tattaccttg tgaagtaggt   1980
 gatctttgtg acccacaccc acaccctatt catacactcc ctcccctttt gaaagtccct   2040
 aataaaaact tgctggtttt tgtggcttgt gaggcatcac ggatcctacc aatgtgtgat   2100
 gtctcccccg gacgcccagc tttaaaattt ctctcttttg tactctgtcc ttctatttct   2160
 caaaccggcc aacacttagg gaaaatagaa aag                                2193



      <210> 1516
      <211> 2193
      <212> DNA
      <213> Homo sapiens


      <400> 1516
 cctagttgag gctaacagtc agtatccagc ctcaacattc agcagaggcc ccagatcagc     60
 gtctgagcca ggccaacaat gaccaaggag gatgggatcc tgggtgcagc tcatcacaag    120
 cgtcggggtg cagcaaaacc atccaggctg gacagtggct ggacagttcc aagaaaagaa    180
 acgcttcact gaagaagtca ttgaatactt ccagaagaaa gttagcccag tgcatctgaa    240
 aatcctgctg actagcgatg aagcctggaa gagattcgtg cgtgtggctg aattgcccag    300
 ggaagaagca gatgctctct atgaagctct gaagaatctt acaccatatg tggctattga    360
 ggacaaagac atgcagcaaa aagaacagca gtttagggag tggtttttga aagagtttcc    420
 tcaaatcaga tggaagattc aggagtccat agaaaggctt cgtgtcattg caaatgagat    480
 tgaaaaggtc cacagaggct gcgtcatcgc caatgtggtg tctggctcca ctggcatcct    540
 gtctgtcatt ggcgttatgt tggcaccatt tacagcaggg ctgagcctga gcattactgc    600
 agctggggta gggctgggaa tagcatctgc cacggctggg atcgcctcca gcatcgtgga    660
 gaacacatac acaaggtcag cagaactcac agccagcagg ctgactgcaa ccagcactga    720
 ccaattggag gcattaaggg acattctgca tgacatcaca cccaatgtgc tttcctttgc    780
 acttgatttt gacgaagcca caaaaatgat tgcgaatgat gtccatacac tcaggagatc    840
 taaagccact gttggacgcc ctttgattgc ttggcgatat gtacctataa atgttgttga    900
 gacactgaga acacgtgggg cccccacccg gatagtgaga aaagtagccc ggaacctggg    960
 caaggccact tcaggtgtcc tcgttgtgct ggatgtagtc aaccttgtgc aagactcact   1020
 ggacttgcac aagggggaaa aatccgagtc tgctgagttg ctgaggcagt gggctcagga   1080
 gctggaggag aatctcaatg agctcaccca tatccatcag agtctaaaag caggctaggc   1140
 ccaattgttg cgggaagtca gggaccccaa acggagggac tggctgaagc catggcagaa   1200
 gaacgtggat tgtgaagatt tcatggacat ttattagttc cccaaattaa tacttttata   1260
 atttcctatg cctgtcttta ccgcaatctc taaacacaaa ttgtgaagat ttcatggaca   1320
 cttatcactt ccccaatcaa tacccttgtg atttcttatg cctgtcttta ctttaatctc   1380
 ctaatcctgt cagctgagga ggatgtatgt cacctcagga ccatgtgata attgcgttaa   1440
 ctgcacaaat tgtagagcat gtgtgtttga acaatatgaa atctgggcac cttgaaaaaa   1500
 gaacaggata acagcaattg ttcagggaat aagagagata accttaaact ctgaccaaca   1560
 gtgagccggg tggaacagag tcatatttct cttctttcaa aagcaaatgg gagaaatatc   1620
 gctgaattct ttttctcagc aaggaacatc cctgagaaag agaatgcacc cctgagggtg   1680
 ggtctataaa tggcctcctt gggtgtggcc attttctatg gtcggagact gtagggatga   1740
 aataaacccc agtctcccat agtgctccca ggcttattag aaagagggaa attcccgcct   1800
 aataaatttt ggtcagaccc ggttgctctc aaaaccctgt ctcctgataa gatgttatca   1860
 atgacaatgg tgcccgaaac ctcatttagc aatttttaat ttctccccgg tcctgtggtc   1920
 ctgtgatctc gccctgccgt ccacttgcct tgtgatattc tattaccttg tgaagtaggt   1980
 gatctttgtg acccacaccc acaccctatt catacactcc ctcccctttt gaaagtccct   2040
 aataaaaact tgctggtttt tgtggcttgt gaggcatcac ggatcctacc aatgtgtgat   2100
 gtctcccccg gacgcccagc tttaaaattt ctctcttttg tactctgtcc ttctatttct   2160
 caaaccggcc aacacttagg gaaaatagaa aag                                2193



      <210> 1517
      <211> 700
      <212> DNA
      <213> Homo sapiens


      <400> 1517
 tttttttttt ttgttgcaga tagaaacttg tgctttaata tatctctggg tgtgtgagca     60
 tgagtgtgtg cgtgtgtgca agtggaacag ctgtctccag ggcctcagtg cctggcctct    120
 gtccttgttc tctgctcatc cttgcagcca atgcaggccc cctccctggc gggccggccc    180
 tgcccctggg caccccagct ggcgggggtc agtctttggt acaatgtgga cactttggtg    240
 tgccgggggc aaggttgggg gggtggccac acagctctca tcatctctgc aacgccaaga    300
 ggaagatggc catgggcccc cacagctgtg ggctggactg gcagggggct ccactgcccg    360
 gcatcaccac cactttattg ggatccgtct gcttccgggg acactccccc ttcttcagtg    420
 tgacgtcatc tatggcaata tcccccaggt agcccgggcc tcgaaccccc tcaaaaataa    480
 tctggaaggg cccactgggg ctgatgggca catgggcctg ctgccacaca ttgcccttat    540
 tgccactgag agaccaggcg tgcgtgtcca gagccccttt gttccgggac cgcaccagga    600
 ggttgaggga gccgatgtgt ttcccgtaca tgtggtagaa gaaggagaca cagtagaact    660
 ttggcgctgg atttgagagg ggactcacta accttggcac                          700



      <210> 1518
      <211> 700
      <212> DNA
      <213> Homo sapiens


      <400> 1518
 tttttttttt ttgttgcaga tagaaacttg tgctttaata tatctctggg tgtgtgagca     60
 tgagtgtgtg cgtgtgtgca agtggaacag ctgtctccag ggcctcagtg cctggcctct    120
 gtccttgttc tctgctcatc cttgcagcca atgcaggccc cctccctggc gggccggccc    180
 tgcccctggg caccccagct ggcgggggtc agtctttggt acaatgtgga cactttggtg    240
 tgccgggggc aaggttgggg gggtggccac acagctctca tcatctctgc aacgccaaga    300
 ggaagatggc catgggcccc cacagctgtg ggctggactg gcagggggct ccactgcccg    360
 gcatcaccac cactttattg ggatccgtct gcttccgggg acactccccc ttcttcagtg    420
 tgacgtcatc tatggcaata tcccccaggt agcccgggcc tcgaaccccc tcaaaaataa    480
 tctggaaggg cccactgggg ctgatgggca catgggcctg ctgccacaca ttgcccttat    540
 tgccactgag agaccaggcg tgcgtgtcca gagccccttt gttccgggac cgcaccagga    600
 ggttgaggga gccgatgtgt ttcccgtaca tgtggtagaa gaaggagaca cagtagaact    660
 ttggcgctgg atttgagagg ggactcacta accttggcac                          700



      <210> 1519
      <211> 1033
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1033)
      <223> n = a,t,c or g


      <400> 1519
 cagtccannn nccggaattc gcgagccgca gtgaggccaa cgccgtgttc gacatcctgg     60
 ccgtgctgca gtctgaggac caggaggaga tccaggaagc agtccgcacg tgcagccgtc    120
 ttttcggggc cttgctggag cggggagagc tgtttgtggg ccagctgccc tctgaggaga    180
 tggtcatgac agggtcccag ggagccacac ggaagtacaa ggtgtggatg agacaccgct    240
 atcacagctg ctgcaatcgc ttgggagagc tcctgggcca cccctccttt caggtcaagg    300
 gggggccctc agcctcttgg ccttgaacgg gctgttcatc ttgattcaca aacacaacct    360
 ggagtaccct gacttctacc ggaagctcta cggcctcttg gacccctctg tctttcacgt    420
 caagtaccgc gcccgcttct tccacctggc tgacctcttc ctgtcctcct cccacctccc    480
 cgcctacctg gtggccgcct tcgccaagcg gctggcccgc ctggccctga cggctccccc    540
 tgaggccctg ctcatggtcc tgcctttcat ctgtaacctg ctgcgccggc accctgcctg    600
 ccgggtcctc gtgcaccgtc cacacggccc tgagttggac gccgacccct acgaccctgg    660
 agaggaggac ccagcccaga gccgggcctt ggagagctcc ctgtgggagc ttcaggccct    720
 ccagcgccac taccaccctg aggtgtccaa agccgccagc gtcatcaacc aggccctgtc    780
 catgcctgag gtcagcatcg cgccactgct ggagctcacg gcctacgaga tctttgagcg    840
 ggacctgaag aagaaggggc ccgagccggt gcccactgga gttttatccc agcccagggc    900
 ctgctgggac ggccgggtga aactctgtgc ccagcacttc cacgctcagc tgaccctggc    960
 ccacctgtga ataaatcttc agctgacccc agcccacctg tgaataaatg ttttttgcag   1020
 gaaaaaaaaa aaa                                                      1033



      <210> 1520
      <211> 556
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(556)
      <223> n = a,t,c or g


      <400> 1520
 gttcacgtct gcagcagtaa gatgggagct ttgtccacgg agcggctaca gtactacact     60
 caggaactgg gggtccggga gcgcagtggc cacagcgtgt ccctcatcga cctctggggc    120
 ctccttgttg agtatctcct gtaccaggag gagaaccctg ccaagctgtc tgaccaacag    180
 gaggcggtcc gccagggtca gaacccttac cccatttaca ccagtgtcaa cgtccgcacc    240
 aacttgagtg gggaagattt tgcagagtgg tgcgagttca cgccctatga ggttggcttc    300
 cccaagtacg gggcttatgt tcccaccgag ctcttcggct cagaactctt catgggacga    360
 ttgctgcagc tccagcctga accccggatc tgttacctgc aaggtatgtg gggcagcgcc    420
 tttgccacca gcctggatga gatcttccta aagaccgccg gctcgggcct cagcttcctg    480
 gagtggtaca gaggcagtgt gaatatcaca gacgactgcc agaagcctca gctgcacaac    540
 ncctcgacgc gggaat                                                    556



      <210> 1521
      <211> 556
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(556)
      <223> n = a,t,c or g


      <400> 1521
 gttcacgtct gcagcagtaa gatgggagct ttgtccacgg agcggctaca gtactacact     60
 caggaactgg gggtccggga gcgcagtggc cacagcgtgt ccctcatcga cctctggggc    120
 ctccttgttg agtatctcct gtaccaggag gagaaccctg ccaagctgtc tgaccaacag    180
 gaggcggtcc gccagggtca gaacccttac cccatttaca ccagtgtcaa cgtccgcacc    240
 aacttgagtg gggaagattt tgcagagtgg tgcgagttca cgccctatga ggttggcttc    300
 cccaagtacg gggcttatgt tcccaccgag ctcttcggct cagaactctt catgggacga    360
 ttgctgcagc tccagcctga accccggatc tgttacctgc aaggtatgtg gggcagcgcc    420
 tttgccacca gcctggatga gatcttccta aagaccgccg gctcgggcct cagcttcctg    480
 gagtggtaca gaggcagtgt gaatatcaca gacgactgcc agaagcctca gctgcacaac    540
 ncctcgacgc gggaat                                                    556



      <210> 1522
      <211> 1524
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1524)
      <223> n = a,t,c or g


      <400> 1522
 ccccaccctt ctgggcccag gattacacac agccacgcga gggagacagc ctgccagcct     60
 gctcagagca gcaccctggc ccccatggag ggcagctgcc cagaggtggc cgtcagggcc    120
 cagagcttcc atctcacgtg tgcagagccc aggcctggcc ggactgggca ggagccctcc    180
 agtgagcgtc cccatgctgg tcaaggggct gggctttggt cagggtcacc gtgggggagg    240
 ggccgcacac aacccaccca cgctcccaca gagggagcca cgcctaggtg cccactgcgc    300
 ccaagtccac gaggcagtgg gcgtgcaggg ccaactttaa tacgggccgg cctgtctggg    360
 ggtcgaggtg gccgctccct ttgtccttgt ggctttccac gggcaggggc ggtcccagcg    420
 agatcgtctc ataaccaaac cagccctgtg cacgagaagt cacgccatgc cccacagcct    480
 ccggtcctgg ctgctggtgg ctcggggacc cgcagggcag gagggtcccg ggtctcgcag    540
 ttccatgagc cccagccgcg gggaccccca tggacaaact tccggggctg cacctgccgg    600
 agcagcgtct cccaagcatc ggaggtcctt tctcagcagg gctgagccct agtggacaga    660
 gccgtgagtg gcaaggcggg agtcagggct ctcggagtcg tcaattcagc aagaaagccc    720
 ctggcccgcc accttcaaac tggaggtggg tgtctagggt gcggaggcag aggcacagag    780
 aggttcagca catgctggtc tcctggggat ccccccacca gcagggaagc tgaggtgcgc    840
 cgggaagcca ggccaaggga gggacccctt aacggaagcc tgcaccagct aatgggagca    900
 gcgaggagca agaggaagcg cggggacccc aaggtctgga ggtgtcttcc tcacagacga    960
 gcgcgagcca cgcggggctg ggactgcagg ggaacagcac cagaggcgtt gggcctgggc   1020
 ctcggccacc ggnggagccc acaaccggca gaagctgggc tcggtcgaga gttaatccgg   1080
 actgagagca ggccagtggc gcctgagtgc gttcaggctc aaggtctcca ggagacgctc   1140
 tggagtcctc ctgcaatgcg cctgcgtggc tgcagctctg ctcagcaccg tgcgcactgg   1200
 gctccaggga acccggtcag gggctggccg tgacccaaac tctctgtggg ccacagtccc   1260
 tggggcatcc ccgtgagtcc cacaagacga ggccacgtta cgaagctgcc accagctccg   1320
 cctgcctggg cctggccttg acagggacgt tttctgtgga ggaaacagag atgtttatga   1380
 cacgccaaag acccacaggc agagacctcc agagagggac gaggccacag gggtggcaag   1440
 ggccagttcc ggggacttcg cactatggaa gggcacgccc agctctgggg gaggcaagtg   1500
 acaaacagga agccaatggg gctg                                          1524



      <210> 1523
      <211> 967
      <212> DNA
      <213> Homo sapiens


      <400> 1523
 cttaaaaaga ggccgatttc atctcaaacc ctggtgcaga ggtcctaggc agagtgggaa     60
 acttgccctg gagaagcaga agcagagacc aaatggctat ctagtaagga tgttttataa    120
 tgaatccttc attcctttaa agagcccatt attttctgag gcttcatggg atgcgtaata    180
 gcccatgcct tcactgctaa gcataaaaca tggagctctt agtagcctct aagacaatca    240
 tccgtcattc ccacgattgc cttcatcaag gccaggtact aaagaagtgc tcaaagaaat    300
 acacatttct gatacaacag ctgatgtaat tttttatccc atttatagaa tgagtgagat    360
 gatatttcga agaataaaga tgccctggct ttggcttgat ctctggtacc ttatgtttaa    420
 agaaggatgg gaacacaaaa agagccttaa gatcctacat acttttacca acagtgtcat    480
 cgcggaacgg gccaatgaaa tgaacgccaa tgaagactgt agaggtgatg gcaggggctc    540
 tgccccctcc aaaaataaac gcagggcctt tcttgacttg cttttaagtg tgactgatga    600
 cgaagggaac aggctaagtc atgaagatat tcgagaagaa gttgacacct tcatgtttga    660
 ggtattgtat attgttaggt tcagatatca ttaaacaaat ttcagttatt gttagaatct    720
 ttatcattat tttttaaaac aatcatattt tagagtaggt taactaaaga agactcatta    780
 tattttaatt agaaattaca aaatttaaga aactgattaa gtaccagctc aacttcttca    840
 gaaaacgatt ttgactagtg ctgggcacag cagtagacac atttgttttt cctcaagaaa    900
 acctaagatt tgtcagagtt ttcccaagca gaagagcagc cagagattgc tctcagttct    960
 ccatgtg                                                              967



      <210> 1524
      <211> 1177
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1177)
      <223> n = a,t,c or g


      <400> 1524
 cccacgcgtc cgctcctctg ggggtcaaga ggaccccgcc agccagcagt gggcacgacc     60
 gcgcttcaca cagccctcca agatgaggcg ccgggtgatc gcacggcccg tgggtagctc    120
 cgtgcggctc aagtgcgtgg ccagcgggca ccctcggccc gacatcacgt ggatgaagga    180
 cgaccaggcc ttgacgcgcc cagaggccgc tgagcccagg aagaagaagt ggacactgag    240
 cctgaagaac ctgcggccgg aggacagcgg caaatacacc tgccgcgtgt cgaaccgcgc    300
 gggcgccatc aacgccacct acaaggtgga tgtgatccag cggacccgtt ccaagcccgt    360
 gctcacaggc acgcaccccg tgaacacgac ggtggacttc ggggggacca cgtccttcca    420
 gtgcaaggtg cgcagcgacg tgaagccggt gatccagtgg ctgaagcgcg tggagtacgg    480
 cgccgagggc cgccacaact ccaccatcga tgtgggcggc cagaagtttg tggtgctgcc    540
 cacgggtgac gtgtggtcgc ggcccgacgg ctcctacctc aataagctgc tcatcacccg    600
 tgcccgccag gacgatgcgg gcatgtacat ctgccttggc gccaacacca tgggctacag    660
 cttccgcagc gccttcctca ccgtgctgcc agacccaaaa ccgccagggc cacctgtggc    720
 ctcctcgtcc tcggccacta gcctgccgtg gcccgtggtc atcggcatcc cagccggcgc    780
 tgtcttcatc ctgggcaccc tgctcctgtg gctttgccag gcccagaaga agccgtgcac    840
 ccccgcgcct gcccctcccc tgcctgggca ccgcccgccg gggacggccc gcgaccgcag    900
 cggagacaag gaccttccct cgttggccgc cctcagcgct ggccctggtg tggggctgtg    960
 tgaggagcat gggtctccgg cagcccccca gcacttactg ggcccaggcc cagttgctgg   1020
 ccctaagttg taccccaaac tctacacagg acattccaca ccacacacat acacacaccc   1080
 cccaccctcc tgccaattaa acagtagcca ttccccnaaa atnnnnnnnn nnnnnnncnn   1140
 nnnnnnnnnn nnnnnctcgg cccccgccta ttcaccg                            1177



      <210> 1525
      <211> 1177
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1177)
      <223> n = a,t,c or g


      <400> 1525
 cccacgcgtc cgctcctctg ggggtcaaga ggaccccgcc agccagcagt gggcacgacc     60
 gcgcttcaca cagccctcca agatgaggcg ccgggtgatc gcacggcccg tgggtagctc    120
 cgtgcggctc aagtgcgtgg ccagcgggca ccctcggccc gacatcacgt ggatgaagga    180
 cgaccaggcc ttgacgcgcc cagaggccgc tgagcccagg aagaagaagt ggacactgag    240
 cctgaagaac ctgcggccgg aggacagcgg caaatacacc tgccgcgtgt cgaaccgcgc    300
 gggcgccatc aacgccacct acaaggtgga tgtgatccag cggacccgtt ccaagcccgt    360
 gctcacaggc acgcaccccg tgaacacgac ggtggacttc ggggggacca cgtccttcca    420
 gtgcaaggtg cgcagcgacg tgaagccggt gatccagtgg ctgaagcgcg tggagtacgg    480
 cgccgagggc cgccacaact ccaccatcga tgtgggcggc cagaagtttg tggtgctgcc    540
 cacgggtgac gtgtggtcgc ggcccgacgg ctcctacctc aataagctgc tcatcacccg    600
 tgcccgccag gacgatgcgg gcatgtacat ctgccttggc gccaacacca tgggctacag    660
 cttccgcagc gccttcctca ccgtgctgcc agacccaaaa ccgccagggc cacctgtggc    720
 ctcctcgtcc tcggccacta gcctgccgtg gcccgtggtc atcggcatcc cagccggcgc    780
 tgtcttcatc ctgggcaccc tgctcctgtg gctttgccag gcccagaaga agccgtgcac    840
 ccccgcgcct gcccctcccc tgcctgggca ccgcccgccg gggacggccc gcgaccgcag    900
 cggagacaag gaccttccct cgttggccgc cctcagcgct ggccctggtg tggggctgtg    960
 tgaggagcat gggtctccgg cagcccccca gcacttactg ggcccaggcc cagttgctgg   1020
 ccctaagttg taccccaaac tctacacagg acattccaca ccacacacat acacacaccc   1080
 cccaccctcc tgccaattaa acagtagcca ttccccnaaa atnnnnnnnn nnnnnnncnn   1140
 nnnnnnnnnn nnnnnctcgg cccccgccta ttcaccg                            1177



      <210> 1526
      <211> 1177
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1177)
      <223> n = a,t,c or g


      <400> 1526
 cccacgcgtc cgctcctctg ggggtcaaga ggaccccgcc agccagcagt gggcacgacc     60
 gcgcttcaca cagccctcca agatgaggcg ccgggtgatc gcacggcccg tgggtagctc    120
 cgtgcggctc aagtgcgtgg ccagcgggca ccctcggccc gacatcacgt ggatgaagga    180
 cgaccaggcc ttgacgcgcc cagaggccgc tgagcccagg aagaagaagt ggacactgag    240
 cctgaagaac ctgcggccgg aggacagcgg caaatacacc tgccgcgtgt cgaaccgcgc    300
 gggcgccatc aacgccacct acaaggtgga tgtgatccag cggacccgtt ccaagcccgt    360
 gctcacaggc acgcaccccg tgaacacgac ggtggacttc ggggggacca cgtccttcca    420
 gtgcaaggtg cgcagcgacg tgaagccggt gatccagtgg ctgaagcgcg tggagtacgg    480
 cgccgagggc cgccacaact ccaccatcga tgtgggcggc cagaagtttg tggtgctgcc    540
 cacgggtgac gtgtggtcgc ggcccgacgg ctcctacctc aataagctgc tcatcacccg    600
 tgcccgccag gacgatgcgg gcatgtacat ctgccttggc gccaacacca tgggctacag    660
 cttccgcagc gccttcctca ccgtgctgcc agacccaaaa ccgccagggc cacctgtggc    720
 ctcctcgtcc tcggccacta gcctgccgtg gcccgtggtc atcggcatcc cagccggcgc    780
 tgtcttcatc ctgggcaccc tgctcctgtg gctttgccag gcccagaaga agccgtgcac    840
 ccccgcgcct gcccctcccc tgcctgggca ccgcccgccg gggacggccc gcgaccgcag    900
 cggagacaag gaccttccct cgttggccgc cctcagcgct ggccctggtg tggggctgtg    960
 tgaggagcat gggtctccgg cagcccccca gcacttactg ggcccaggcc cagttgctgg   1020
 ccctaagttg taccccaaac tctacacagg acattccaca ccacacacat acacacaccc   1080
 cccaccctcc tgccaattaa acagtagcca ttccccnaaa atnnnnnnnn nnnnnnncnn   1140
 nnnnnnnnnn nnnnnctcgg cccccgccta ttcaccg                            1177



      <210> 1527
      <211> 1204
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1204)
      <223> n = a,t,c or g


      <400> 1527
 cccccaactg gaaacgaaac ccttccctct tttgaaaggt tttccccctn atgaaaaagg     60
 tggtgcaaga ggatccctcc tacctcccaa gtccctggac tatgaccgct tcagccgcaa    120
 cgaaccccat tgggaagggt gtccatcccc cttaacaagg tggacctgac ccagatgcag    180
 accttctgga aggatctgaa gccatgcagc gatgggagtg ggagccgagg ggagctgctc    240
 ttgtctctct gctacaaccc ctctgccaac tccatcatcg tgaacatcat caaagcccgg    300
 aacctcaaag ccatgggaca tcgggggcac atcagacccc ttacgtgaag gtatggctga    360
 ttgtacaaag gacaagcggg tgggagaaga agaagacggt gacgattgaa gaggaacctg    420
 aaccccatgt ttcaatgagt ccttcgcctt cgatatcccc acggagaagc tgagggagac    480
 gaccatcatc atcactgtca tggacaagga caagctcagc cgcaatgacg tcatcggcaa    540
 gatctacctg tcctggaaga gcgggccagg ggaggtgaag cactggaagg acatgattgc    600
 ccgtccccgg cagcccgtgg cccagtggca ccagctgaag gcctgagtgg ggccaaggga    660
 ggcccagggg gccgagggcc caggtcccca tcatgccctc accactttat gcacaacgcc    720
 cggcctgagc cccctgccat agggagggga ggaccctgag ggctcagcca gggaggggtc    780
 ccaggactca actgggcccc gtttctagga agtaccagcc ccatccccca cagtccagct    840
 ccggggaagg ggctctggga ggcattttcc tgctttgccc cttttcttcc tgacttacta    900
 atactaaaga agttggggga gctcgagagc cagacggcca gacaggcaga cccctccaga    960
 ggcccgccca ggtgggcatg gtcccccatt ttctttaagg cagcaccctg gagtggagag   1020
 aggccactcc ctctccagcc cccgatgtgg acccggggag gggaggctga ggcgtttggc   1080
 cccggcctgg ccaggagagg cccatcccca gggcagtttc aggtgccggc tgggccctga   1140
 atgtcgagga taggcatata gcccgttgct gcggcatgga ggtggtgccg ttccacaatc   1200
 ggtc                                                                1204



      <210> 1528
      <211> 1036
      <212> DNA
      <213> Homo sapiens


      <400> 1528
 agggagggga aaaaggtgtc tagctccttt ctgcttaaaa aagcacaggg agatcgcggg     60
 cagctttgca gtcgctgcct tctcgcgcct gaccatgcac ccctgcatct tcctgctggg    120
 ccacaggcga gcgctttatt tctggagctg agggctaaaa cttttttgac ttttcttctc    180
 ctcaacatct gaatcatgcc atgtgcccag aggagctggc ttgcaaacct ttccgtggtg    240
 gctcagctcc ttaactttgg ggcgctttgc tatgggagac agcctcagcc aggcccggtt    300
 cgcttcccgg acaggaggca agagcatttt atcaagggcc tgccagaata ccacgtggtg    360
 ggtccagtcc gagtagatgc cagtgggcat tttttgtcat atggcttgca ctatcccatc    420
 acgagcagca ggaggaagag agatttggat ggctcagagg actgggtgta ctacagaatt    480
 tttcacgagg agaaggacct gttttttaac ttgacggtca atcaaggatt tctttccaat    540
 agctacatca tggagaagag atatgggaac ctctcccatg ttaagatgat ggcttcctct    600
 gcccccctct gccatctcag tggcacggtt ctacagcagg gcaccagagt tgggacggca    660
 gccctcagtg cctgccatgg actgactgga tttttccaac taccacatgg agactttttc    720
 attgaacccg tgaagaagca tccactggtt gagggagggt accacccgca catcgtttac    780
 aggaggcaga aagttccaga aaccaaggag ccaacctgtg gattaaaggg tattgtgact    840
 cacatgtcct cctgggttga agaatctgtt ttgttctttt ggtagtttta ttaaaacatg    900
 acctattctt actcaagtct cttatctcct ctgtattctt ttttttttaa tatcttcatg    960
 acattcaaat ctcttctgta ttctcttgcc agaaagtgta cattcttttt gcttgtataa   1020
 accctttcac ttgtca                                                   1036



      <210> 1529
      <211> 631
      <212> DNA
      <213> Homo sapiens


      <400> 1529
 gtgtggtgga attcccggag aaggtgaaat tctgtgtgct ccctccggcg agagactttg     60
 tcagctcccg cacagtaaca tcctgaataa agtcaaaact caaccaacag gtggaagtcc    120
 aagaatccga gtggaggctc accgaggcga aggggccaac catgggaaag gagagtggat    180
 gggactcagg cagggctgct gtagcagctg tggtcggagg agttgtggct gtggggactg    240
 tgctcgtggc gctcagtgcc atgggcttca cctcagtagg aatcgccgca tcctccatag    300
 cagccaagat gatgtctaca gcagccattg ccaacggggg cggagttgct gctggcagtc    360
 tggtggctat tctgcagtca gtgggggcag ctggactctc tgtgacatct aaagttatcg    420
 ggggctttgc tgggacagct cttggggcct ggctgggttc acccccttcc agctgaacac    480
 cacactgagg cagggagttg gctctcttgg tggagatgac tttcctgggc ctctggatga    540
 caatcttcca aaggacaagt ctcctactcc caaaactatt taaggaagca tgaaaaataa    600
 agatgctggt tatcttctcc taaaaaaaaa a                                   631



      <210> 1530
      <211> 1991
      <212> DNA
      <213> Homo sapiens


      <400> 1530
 tttttttttt ttctgatcca tgcatccttt attccattac caaccactgt gccgcatcca     60
 agcaacagta cacaaactgg caatcaaccg cagtccagtt gtacaacgat ctgaggctta    120
 cagtacattt aaggctttta aatgtggaaa aaaaaattaa aaccaaagaa cccccaaatc    180
 caaaccccta accaacacaa gtagtatagc aatgttaagc atctcctatt tctgatgctt    240
 atttggcgca acttccagtg tcaaaaccca aataattcct aaactaaaaa gattagttta    300
 gtgaaatttt aattacataa attcttcaaa gcataaactt ggaatttttg tcttggaaat    360
 gttataaaat ttttaatagc aaaacatagg aataaaaaca tattaacaaa atgtattcaa    420
 tcatttacat tacaaacaag gaatctgcag ttcattgttg tagcctgaca aaagaaatca    480
 tatctaccat taagaatcta tgcacaatgt gattgcaaat atgtacagta ctttaaaaaa    540
 gcctacaagg aggactttac agaaggaaag tcagctaggc tctttgttaa accaaccaga    600
 caatcaaaat agtaaaactc tgttggctag taataaattt acacttaaaa aaacccctag    660
 tttctttttg tttaagaata ttccagttat atttatatgg ttacagttga tgaagctgta    720
 cacgagagtt ccagtaaatt acccttcagt tcatttgtcc gggaaagatc agcatgttaa    780
 caaaaaataa taaaggaatt ttcaccacac tagctttcca gttacactat cacagcttca    840
 caaatggatt gaacccatgt atccagtggc agaaagagag ctgcatgtga aataccgaga    900
 acattggtgg caacagggca agtcctgcat gaatgtcaga aatgatggat aaggttgaga    960
 aacagatgcg aggctacttt atacagcact agaaaattgt ccctacattc agctctcatt   1020
 cccattcctg caaggtaatg aagctgggaa tcacgactgt tcagtttaac gtgttgtgtg   1080
 aattagcaga accacctcta gatacaaaag actgagattt catcagctct ttgattagaa   1140
 caccctaaag gttgggcact tcttcatggt tatcaagcct ttacagctac ccagttaaag   1200
 catgtgcaaa acagaggact cttctgttca cagtaaatga ggtaagatca agttgttgtc   1260
 ttcaggaatt aggaagttcg tgagatatga actgttttag tctttctagg tattgtgcat   1320
 aaagctctat gtcattatgc ccagcccctt caacccaaag gggctccacg gctcggggac   1380
 agcgctcgta catcgctagg ccatgggaga aatcgatgac ctcatcctct gtaccatgaa   1440
 tgaccaacac aggagaggtg actttagata tcttgtcaat gctggggaaa gcatcaaagc   1500
 agtatgtttt cctggtatcc ggaaaagcca cacgcaaacc agacatcaga ggggaatgga   1560
 gaattaccgc tgcgcattca tacctcgagg ccaagtctac cgtggggaca gtcccaatgc   1620
 tctgaccata gaggataatg ttctcgggac tcacgccata ccgggtgcgc agcgcctgcc   1680
 acgcggcgtc gatgtcggcg tagaggttct tctcggaggg cttgcccgag ctgacgccgt   1740
 atcccgagta gtcgtaggag aagatgttgc agttgatgcg ggagccgagg ccaatgtaga   1800
 agctgcacat ctggcccagg tccacggcgt tgccgtgcga gaagagcagc gtgtagcggc   1860
 tggagggcgc gcagcgcacg aacatgcagc cgagccggtt gtcccgggcc gtgcgcgaga   1920
 agaagacctc gacggcgttc cagcccgctg cgagtattgc cagtcggcgc gctcgctgag   1980
 gtgcaggctg c                                                        1991



      <210> 1531
      <211> 1991
      <212> DNA
      <213> Homo sapiens


      <400> 1531
 tttttttttt ttctgatcca tgcatccttt attccattac caaccactgt gccgcatcca     60
 agcaacagta cacaaactgg caatcaaccg cagtccagtt gtacaacgat ctgaggctta    120
 cagtacattt aaggctttta aatgtggaaa aaaaaattaa aaccaaagaa cccccaaatc    180
 caaaccccta accaacacaa gtagtatagc aatgttaagc atctcctatt tctgatgctt    240
 atttggcgca acttccagtg tcaaaaccca aataattcct aaactaaaaa gattagttta    300
 gtgaaatttt aattacataa attcttcaaa gcataaactt ggaatttttg tcttggaaat    360
 gttataaaat ttttaatagc aaaacatagg aataaaaaca tattaacaaa atgtattcaa    420
 tcatttacat tacaaacaag gaatctgcag ttcattgttg tagcctgaca aaagaaatca    480
 tatctaccat taagaatcta tgcacaatgt gattgcaaat atgtacagta ctttaaaaaa    540
 gcctacaagg aggactttac agaaggaaag tcagctaggc tctttgttaa accaaccaga    600
 caatcaaaat agtaaaactc tgttggctag taataaattt acacttaaaa aaacccctag    660
 tttctttttg tttaagaata ttccagttat atttatatgg ttacagttga tgaagctgta    720
 cacgagagtt ccagtaaatt acccttcagt tcatttgtcc gggaaagatc agcatgttaa    780
 caaaaaataa taaaggaatt ttcaccacac tagctttcca gttacactat cacagcttca    840
 caaatggatt gaacccatgt atccagtggc agaaagagag ctgcatgtga aataccgaga    900
 acattggtgg caacagggca agtcctgcat gaatgtcaga aatgatggat aaggttgaga    960
 aacagatgcg aggctacttt atacagcact agaaaattgt ccctacattc agctctcatt   1020
 cccattcctg caaggtaatg aagctgggaa tcacgactgt tcagtttaac gtgttgtgtg   1080
 aattagcaga accacctcta gatacaaaag actgagattt catcagctct ttgattagaa   1140
 caccctaaag gttgggcact tcttcatggt tatcaagcct ttacagctac ccagttaaag   1200
 catgtgcaaa acagaggact cttctgttca cagtaaatga ggtaagatca agttgttgtc   1260
 ttcaggaatt aggaagttcg tgagatatga actgttttag tctttctagg tattgtgcat   1320
 aaagctctat gtcattatgc ccagcccctt caacccaaag gggctccacg gctcggggac   1380
 agcgctcgta catcgctagg ccatgggaga aatcgatgac ctcatcctct gtaccatgaa   1440
 tgaccaacac aggagaggtg actttagata tcttgtcaat gctggggaaa gcatcaaagc   1500
 agtatgtttt cctggtatcc ggaaaagcca cacgcaaacc agacatcaga ggggaatgga   1560
 gaattaccgc tgcgcattca tacctcgagg ccaagtctac cgtggggaca gtcccaatgc   1620
 tctgaccata gaggataatg ttctcgggac tcacgccata ccgggtgcgc agcgcctgcc   1680
 acgcggcgtc gatgtcggcg tagaggttct tctcggaggg cttgcccgag ctgacgccgt   1740
 atcccgagta gtcgtaggag aagatgttgc agttgatgcg ggagccgagg ccaatgtaga   1800
 agctgcacat ctggcccagg tccacggcgt tgccgtgcga gaagagcagc gtgtagcggc   1860
 tggagggcgc gcagcgcacg aacatgcagc cgagccggtt gtcccgggcc gtgcgcgaga   1920
 agaagacctc gacggcgttc cagcccgctg cgagtattgc cagtcggcgc gctcgctgag   1980
 gtgcaggctg c                                                        1991



      <210> 1532
      <211> 383
      <212> DNA
      <213> Homo sapiens


      <400> 1532
 ggccaccggg acccaaaggt gatcaggggg atgaaggaaa ggaaggcagg cctggcatcc     60
 ctggattgcc tggacttcga ggtctgcccg gggagagagg taccccagga ttgcccgggc    120
 ccaagggcaa tgatgggaag ctgggggcca caggaccaat gggcatgcgt gggttcaaag    180
 gtgaccgagg cccaaaagga gagaaaggag agaaaggaga cagagctggg gatgccagtg    240
 gcgtggaggc cccgatgatg atccgcctgg tgaatggctc aggtccgcac gagggccgcg    300
 tggaagtgta ccacgaccgg cgctggggca ccgtgtgtga cgacggctgg gacaagaagg    360
 acggagacgt ggtgtgccgc atg                                            383



      <210> 1533
      <211> 383
      <212> DNA
      <213> Homo sapiens


      <400> 1533
 ggccaccggg acccaaaggt gatcaggggg atgaaggaaa ggaaggcagg cctggcatcc     60
 ctggattgcc tggacttcga ggtctgcccg gggagagagg taccccagga ttgcccgggc    120
 ccaagggcaa tgatgggaag ctgggggcca caggaccaat gggcatgcgt gggttcaaag    180
 gtgaccgagg cccaaaagga gagaaaggag agaaaggaga cagagctggg gatgccagtg    240
 gcgtggaggc cccgatgatg atccgcctgg tgaatggctc aggtccgcac gagggccgcg    300
 tggaagtgta ccacgaccgg cgctggggca ccgtgtgtga cgacggctgg gacaagaagg    360
 acggagacgt ggtgtgccgc atg                                            383



      <210> 1534
      <211> 3428
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3428)
      <223> n = a,t,c or g


      <400> 1534
 ggaattcgta cttcatcacc taaaactgaa ggcaagcacg aagaaactgt taataaagaa     60
 tcggatatga aggtgccaac tgtaagtttg aaagtatctg aaagtgtaat tgatgtgaaa    120
 acaactatgg aaagtatatc taatacgtct acgcagtctc tcacagcaga aacaaaggac    180
 atagctttgg aacctaagga acaaaaacat gaagacaggc agagcaatac accttctcct    240
 cctgttagta ccttttcatc aggtacttct accaccagtg atattgaagt tttagatcat    300
 gaaagtgtaa taagtgagag ctcagcgagc tcgagacaag agactacaga ttcaaaatca    360
 agtcttcact tgatgcagac atcttttcag cttctctctg catctgcttg tcctgaatat    420
 aatcgtttag atgatttcca aaaactcact gagagttgct gttcatctga tgcttttgaa    480
 agaatagact catttagtgt acagtcatta gatagccgga gtgtaagtga aatcaattca    540
 gatgatgaat tgtcaggcaa gggatatgct ttagtgccta ttatagttaa ttcttcaact    600
 ccaaagtcta aaacagttga atctgctgaa ggaaaatctg aagaagtaaa tgaaacatta    660
 gttataccca ctgaggaagc agaaatggaa gaaagtggac gaagtgcaac tcctgttaac    720
 tgtgaacagc ctgatatctt ggtttcttct acaccaataa atgaaggaca gactgtgtta    780
 gacaaggtgg ctgagcagtg tgaacctgct gaaagtcagc cagaagcact ttctgagaag    840
 gaagatgttt gcaagacagt tgaatttctg aatgaaaagc tggaaaaaag ggaggctcag    900
 ttattatctc ttagtaagga aaaagcactt ctagaagaag cttttgataa cctgaaagat    960
 gaaatgttca gagtgaaaga agaaagcagt agcatttctt ccttgaaaga tgagtttact   1020
 caaagaattg cagaagcaga aaagaaagtt caactagcct gcaaagagag agatgctgct   1080
 aaaaaggaaa tcaaaaacat aaaagaagaa cttgccacta gattaaatag tagtgaaact   1140
 gcagaccttt tgaaagagaa agatgagcag atccgagggt taatggaaga aggagaaaaa   1200
 ctttcaaaac agcagctgca caattctaac atcatcaaga aattaagagc taaagacaag   1260
 gagaatgaaa atatggttgc aaagctgaac aaaaaagtta aagagctaga agaggagttg   1320
 cagcatttga aacaggtcct tgatggcaaa gaagaggttg agaaacaaca tagagaaaat   1380
 attaaaaaac taaattccat ggtagaacgc caagagaaag atcttggccg tcttcaggta   1440
 gacatggatg aacttgaaga aaagaaccga agtattcagg ctgccctgga tagtgcatac   1500
 aaagaactta ctgatcttca caaagccaat gctgcaaagg atagtgaggc acaggaagct   1560
 gctctgagcc gtgaaatgaa agctaaagaa gaactttctg cagcattaga gaaggcccaa   1620
 gaagaagccc gtcagcagca agaaacatta gccattcaag tgggggacct taggcttgca   1680
 ttgcagcgta cagaacaagc ggctgccaga aaggaggatt atttacgcca tgagatcggt   1740
 gaacttcagc agagactcca ggaagcagag aatcgaaacc aggaactgag tcaaagtgtt   1800
 tcatcaacaa caagaccatt gcttcgacaa atagaaaatt tgcaagcaac cctgggatcc   1860
 cagacatcgt cgtgggagaa attagagaag aatctttctg ataggcttgg tgaatcccag   1920
 accttgctgg cagcagcagt tgagagagaa cgtgcagcta cagaagaact ccttgctaac   1980
 aaaattcaga tgtcttccat ggagtcacag aattctcttt taagacagga aaacagtaga   2040
 tttcaagccc agctagaatc agagaaaaat aggctgtgta aactggagga tgagaacaat   2100
 aggtaccagg ttgaattgga aaacctaaaa gatgaatatg taagaacact tgaagagacg   2160
 aggaaagaaa agacattgtt gaatagtcag ttagaaatgg aaagaatgaa agttgaacaa   2220
 gaaaggaaga aagccatttt tactcaagaa acaataaaag aaaaggaacg caagccattt   2280
 tctgtttcta gcactcccac catgtcacgc tcaagttcaa taagtggtgt tgatatggca   2340
 ggactacaga catcttttct gtctcaggat gagtctcatg atcactcatt tggaccaatg   2400
 cctatatcag caaatggaag caatctttat gatgctgtaa ggatgggagc aggatcaagc   2460
 ataattgaaa acctacagtc tcagctaaag ctaagggaag gggaaatcac tcatttacag   2520
 ctagaaattg gcaatctaga aaaaactcga tcaataatgg ctgaagaact agttaaatta   2580
 acaaatcaaa atgatgaact tgaagagaag gtgaaggaga tacccaaact tagaactcag   2640
 ctaagagatt tggatcaaag gtacaacact attctgcaga tgtatggaga aaaagcagaa   2700
 gaggcagaag aacttcgatt agatctcgaa gatgtaaaaa atatgtacaa aactcaaata   2760
 gatgaacttt taagacaaag tctcagttaa cttgtgaaaa ttgaattccc atcaaactga   2820
 atgtaagcat ttaatatcta aacatttaat gcggacttcc aataaattct tttatataat   2880
 tatatagtgg gatttactgt agagtgtaaa aattttttta aaattgattt acactatgta   2940
 gtaatattta cagttaaatt attttgtgca atatttgaac tttatttttg aaactattct   3000
 ttaaagattt attttttaaa gcattcattt tttttccttg aatagcacag agatttatta   3060
 ctttatcctc atataaatat ggctagagaa gaagaatggt gttcatatat gtattgtaga   3120
 tatacaacta gttgtatcta taatttgtaa gtgtttatat atatattaag aacatttgaa   3180
 gagtaatgtt aacatactga aactttgaaa tctttcacat ttaaaatttc aacatatctt   3240
 aattactgct catgaaaatg tacattaagt gttaaagtaa aaaattatta aatctgtggg   3300
 ctattaaatt ttaaactaat tttttttccc tttaaaagta aggagtcaca ctggacactg   3360
 tctggaaatt taaaggngtg gaatggttta aactnaaaaa nattttggtc cggaaatttn   3420
 ttttcacc                                                            3428



      <210> 1535
      <211> 2234
      <212> DNA
      <213> Homo sapiens


      <400> 1535
 atggctgcct ccagtatccg tgacgagagg acgcgaactt actacctccc agtcgtccgt     60
 gctccgtaca cctgcaactt cagaccttcc tcggccgccg taggccggct tggaggctgg    120
 gggagggccc agaagtggaa taattcagga aagtgcaggt tctgggaagt ctcggaatca    180
 ctgaccctgg aggatgtggc tgtggagttc acttgggagg agtggcagct cctcggccct    240
 gctcagaagg acctgtaccg agacgtgatg ttggagaact atagcaacct cgtgtcagtg    300
 gggtatcaag ccagcaaacc agatgcactc ttcaagttgg aacaaggaga gccatggaca    360
 gtagaaaatg aaatccacag ccaaatctgt ccaggtatgt atgcactgta caggaaaaaa    420
 cataatggat atagggttaa gtatgattca gagtttcagg catccatggt gtggggggtg    480
 tcttggaaca tatcgcccat agatgaggga ttactgtata tttataaaag acataaggaa    540
 tttactactg aagtagacaa agggtgtgag acaaacatac aaatgaaaga tgataaaatc    600
 aagaaagttg acaatcatct acagatgcac tcacaaaagc aaagatgtct gaagagagtg    660
 gaacaatgcc ataaacataa tgcatttgga aacatcattc atcagaggaa aagtgatttt    720
 cctttaaggc aaaatcatga tacatttgac ttacatggga aaatactgaa atcaaattta    780
 agtttagtca accagaacaa aaggtatgaa atcaagaatt ctgtgggggt taatggagat    840
 gggaaatcct tccttcatgc caagcatgaa caatttcata atgaaatgaa cttccccgaa    900
 ggtggaaatt ctgtgaatac aaattcacaa ttcattaagc atcagcgaac tcaaaacata    960
 gataaacccc atgtatgcac tgagtgtggg aaggctttcc tcaagaagtc tcgcctcatc   1020
 tatcatcaga gagttcacac tggggagaaa cctcatggat gcagtatatg tgggaaagcc   1080
 ttctccagaa agtccgggct cactgaacac cagagaaacc acacaggaga gaaaccctat   1140
 gaatgcactg aatgtgacaa agcattccgc tggaaatcac agctcaatgc acaccagaaa   1200
 attcatacag gagagaagtc atatatatgc agtgattgtg gaaaaggctt catcaagaag   1260
 tctcggctca ttaatcatca gagagttcat acaggagaga aaccacatgg atgcagcctg   1320
 tgtgggaagg ccttctccaa aaggtccagg ctcactgaac accagagaac tcatacagga   1380
 gagaaaccct atgaatgcac tgaatgtgac aaagcattcc gctggaaatc acagctcaat   1440
 gcacatcaga aagctcacac aggagagaag tcatatatat gccgtgattg tggaaaaggc   1500
 ttcattcaga agggaaatct cattgtacat cagcgaattc atactggaga aaaaccctat   1560
 atatgcaatg aatgtggaaa aggcttcatc caaaagggca acctccttat tcatcgacgt   1620
 actcacactg gagagaaacc ctatgtatgc aatgaatgtg ggaaaggctt cagccagaag   1680
 acatgtttaa tatcccatca gagatttcac acaggaaaga caccctttgt atgtactgag   1740
 tgtggaaaat cctgctcaca caagtcaggt ctcattaacc accagagaat tcacacagga   1800
 gagaaaccct atacatgcag tgactgtggg aaagctttca gagataaatc atgtctcaac   1860
 agacatcgga gaactcatac aggggagaga ccgtatggat gctctgattg tgggaaagct   1920
 ttctcccact tgtcatgcct tgtttatcat aagggaatgc tgcatgcaag agagaaatgt   1980
 gtaggttcag tcaaattgga aaatccttgc tcagagagtc atagcttatc acatacacgt   2040
 gatctcatac aggataaaga ctctgttaac atggtgactc tgcagatgcc ttctgtggca   2100
 gctcagacct cattaactaa cagtgcgttc caagcagaga gcaaagtagc cattgtgagc   2160
 cagcctgttg ccagaagttc agtctcagca gatagtagaa ttgccacgga attaaaaacc   2220
 attatgaatg caga                                                     2234



      <210> 1536
      <211> 1503
      <212> DNA
      <213> Homo sapiens


      <400> 1536
 gccggcttgc tttcccctgc ggtcgtccag actattgggc gctagcgaga cgaactattg     60
 gtacggggct agagaggaag gctttgggat tgccggggag cagcgagcga ccgacttccg    120
 tttccagtta ccaaggcacg aggatccggt gttccaaccc agggggaaaa atgcggcctt    180
 tgactgaaga ggagacccgt gtcatgtttg agaagatagc gaaatacatt ggggagaatc    240
 ttcaactgct ggtggaccgg cccgatggca cctactgttt ccgtctgcac aacgaccggg    300
 tgtactatgt gagtgagaag attatgaagc tggccgccaa tatttccggg gacaagctgg    360
 tgtcgctggg gacctgcttt ggaaaattca ctaaaaccca caagtttcgg ttgcacgtca    420
 cagctctgga ttaccttgca ccttatgcca agtataaagt ttggataaag cctggtgcag    480
 agcagtcctt cctgtatggg aaccatgtgt tgaaatctgg tctgggtcga atcactgaaa    540
 atacttctca gtaccagggc gtggtggtgt actccatggc agacatccct ttgggttttg    600
 gggtggcagc caaatctaca caagactgca gaaaagtaga ccccatggcg attgtggtat    660
 ttcatcaagc agacattggg gaatatgtgc ggcatgaaga gacgttgact taaaacgaag    720
 ccattccaag gacagacggc tgtatggaaa ggccgagctt tgtttcctgt gtttgtgtgg    780
 actccaccat catgttgaat tttgtcaaca ctctggcctc ttcagggact tcttatttac    840
 tgtactctct atcactgaca aatgcaggct ggattcttat tatatacaga gatggctcaa    900
 aaatggggtt tcagatcttt gtgacgaaat agaatactgt ttcatatttg aatcagaggg    960
 cttcttgttc tgagaaatag gttcaaaatc attggaacca ggaacaagaa tagcttattg   1020
 ttatctgtga taacactgtt ttctaaacac aaggattttc ttttttatta atatgcaaca   1080
 tagacattgc cataacagaa taataaacca catgtggggt tttaaaaatg aaatttggct   1140
 aataggagca attcagctat ttttctatac agtaattggt gtgtggtata gaagaaaaac   1200
 gggttcaaac cccacttctg ccacctacca gctatatggc cttgaatgag tcattcagct   1260
 ttaataaggt tcattttctt ctgtttaaaa agacacaaaa cttgaaaatc agctttggcc   1320
 atctacctga gaattagaaa gtctgatttt tggaattaga aatcatgatt gtaggctggg   1380
 cacagtggct cgcgcctgta atcccagcac tttgggaggc caaggcggac ggatcacttg   1440
 aggttaggag tttgagacca gcctggccaa catggtgaaa ccccatctct actaaaaaaa   1500
 aaa                                                                 1503



      <210> 1537
      <211> 1301
      <212> DNA
      <213> Homo sapiens


      <400> 1537
 gagggtggca caggcgtgcg gtcgctgagc ttctaccagc acatcatcac tgtgggcacc     60
 ggccatggtt ccctgctctt ctatgacatc cgcgcccaga agttcctgga ggagagggcc    120
 tcttccagcc tggactccat gccggggccc gcagggagga agctcaagct tgcctgcggc    180
 agaggctggc tcaaccaaga tgacgtctgg gtgaactact ttggtggcat gggagagttc    240
 cccaatgcgc tctacaccca ctgctacaac tggccggaga tgaagctctt tgtggctggg    300
 gggcctctcc cttcaggcct ccatgggaac tacgcaggcc tctggagtta aggatggacg    360
 ccttgttctc aaagtgcaca ggtggaacca gtccaactta cgtgtgctta atgtattagg    420
 cagagaaaga aagagagaga gcgggagcga gagagcacaa gtggtccttt cggcagtcaa    480
 aactttggct ttaaaactct cattcacgtt tcccaacagc agtatatttt tgccttctca    540
 ttcacagagt tttggctaaa ccttaattgt gttctgtctt tcagtgattc acataccctc    600
 cttctttagg ttgatgtagt catagtcttc actactattc agtacgttag ttttatcaat    660
 attgcaatag tgttcagatc ttttacacat gttagatgtg tggtgttttg gggaaatgtg    720
 agctacaaag catctttggg gttgttttga ggaactaccc atcatttata gccttactct    780
 aattacaaaa tgcagttcag gttctagatt gccaccattc tagagtgtgg cacacaccat    840
 tctagggcgt gattcatttg gatgttggaa actcaatgtc tgttgtttgt atagtgttga    900
 tgtgtaaaat gctttaaaaa tatgttctgt tagttagaaa tcttacaatg ttgttcatac    960
 tattaatcaa catttttggt tattcagtaa aacatttact atcctcaggc cctccgtgtt   1020
 cttatttaaa gccgctgtat tatggcctgc ttttctatgc tacagatttt cagaactact   1080
 caattctggt ctatatatgt ggtagtgcaa tcagggaggt atttttgggg gtatatgggg   1140
 tacacatctc tttaaattca ggtagctatt tacagtgaaa agccagttgt ggcagttgtg   1200
 ctcagagtag gtgttgattt tttattactg tatacatgga taattctgga tccagtatgt   1260
 gatgcgttgc agaaaaataa ataaaatgtg ttaaaaatct t                       1301



      <210> 1538
      <211> 1852
      <212> DNA
      <213> Homo sapiens


      <400> 1538
 gactaggaag ctctgatagg agtatctgtt tccagaagaa gcaattcttt ggaacagaca     60
 gccaagccct tggtgacagg catgctggag agcaaagagg aggatgtgga ggtagaaaag    120
 tggtctcctt tgagtctgca tcttcataca ctgaagggat atggacaggt gcaagaggcc    180
 agatactcac ccaaggtgag gccttcaaac ttatgtactc cccatggctt ttcacaggtg    240
 agtctgttga aatagtcagt gaggtcagag tagaagtagg agaacttaac atcataaaag    300
 actggggaag agagagtgtg gagaaaggag gggcagtaat atccatggaa gcagagagag    360
 taaaaggcca agctatgata gcaactggtg gagtgataac tggcctggcc gccttgaaaa    420
 ggcaagactc tgccagatca cagcagcatg tcaacctcag cccgtctcct gctacccaag    480
 agaagaagcc catcaggcgc cggccccggg cagatgttgt ggttgttcgt ggcaaaatcc    540
 ggctttattc cccatctggt ttttttctta ttttaggagt gctcatctcc attataggaa    600
 ttgctatggc cgttcttgga tattggcccc aaaaagaaca ttttattgat gctgaaacaa    660
 cactgtcaac aaatgaaact caggtcattc ggaatgaagg cggtgtggtg gttcgcttct    720
 ttgagcagca tttgcattct gataagatga aaatgcttgg cccattcacc atggggattg    780
 gcattttcat tttcatttgt gctaatgcca ttcttcatga aaaccgtgac aaagagacca    840
 aaatcataca catgagggat atctattcca cagtcattga cattcacacg ctaagaatca    900
 aggagcaaag gcaaatgaac ggcatgtaca ctggtttgat gggagaaaca gaagtaaaac    960
 agaatgggag ctcctgtgcc tcgagattgg cagcaaatac gatcgcctct ttctcgggtt   1020
 ttcggagcag ttttcgaatg gacagctccg tggaggagga tgaacttatg ttaaatgaaa   1080
 gtaagagttc tgggcatctt atgccccctt tgctctctga cagctctgtg tctgtctttg   1140
 gcctctatcc acctccttcc aagacaactg atgataagac cagcggctct aagaaatgtg   1200
 aaaccaagtc aattgtgtca tcgtccatca gtgcttttac attgcctgtg atcaaactta   1260
 ataactgtgt tattgatgag cccagtatag ataacatcac tgaagatgct gacaacctca   1320
 aaagtaggtc aaggaatttg tcaatgggat tcccttgtgg ttccttttgc ccaacaccag   1380
 tgaatccttc cagcccgtca gcacagtgct accaaggaat aattccattg gggagtcgtt   1440
 gtcgagtcag tacaagtcat ctatggctct cggacctggg gctggacagc tcttgtctcc   1500
 tggggctgcc agaagacagt ttgggtccaa tacatccttg catttgctct cgtcacactc   1560
 aaagtccttg gacttagacc ggggtccctc cactctaact gttcaggcag aacaacggaa   1620
 acatccaagt tggcctaagt tggatcggaa caacagcaag ggatatatga aactagagaa   1680
 caaagaagac ccgatggata ggttgcttgt gccccaagtt gccatcaaaa aggactttac   1740
 caataaggag aagcttctta tgatttcaag atctcacaat aatttgagtt ttgaacatga   1800
 tgagtttttg agtaacaacc taaagagggg aacttctgaa acaaggtttt aa           1852



      <210> 1539
      <211> 1719
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1719)
      <223> n = a,t,c or g


      <400> 1539
 cccggcctcc aatctgcttc catgggggtt ggctttctga gtgggagaaa tgactctaat     60
 ctggagacat ttgctgagac ccttgtgcct ggtcacttcc gctcccagga tccttgagat    120
 gcatcctttc ctgagcctag gtacttcccg gacatcagta accaagctca gtcttcatac    180
 aaagcccaga atgcctccat gtgacttcat gcctgaaaga taccaggtca ttttcttggt    240
 gaacagtggc tcagaagcca atgagctggc catgctgatg gccagggcgc actcaaacaa    300
 catagacatc atttctttca gaggagccta ccatggatgc agtccttaca cacttggctt    360
 gacaaacgta gggatctaca agatggaact ccctggtggg acaggttgcc aaccaacaat    420
 gtgtccagat gtttttcgtg gcccttgggg aggaagccac tgtcgagatt ctccagtgca    480
 aacaatcagg aagtgcagct gtgcaccaga ctgctgccaa gctaaagatc agtatattga    540
 gcaattcaaa gatacgctga gcacatctgt ggccaagtca attgctggat ttttcgcaga    600
 acctattcaa ggtgtgaatg gagttgtcca gtacccaaag gggtttctaa aggaagcctt    660
 tgagctggtg cgagcaaggg gaggcgtgtg cattgcaaat gaagtgcaga caggatttgg    720
 aaggttgggc tctcacttct ggggcttcca aacccacgat gtcctgcctg acattgtcac    780
 catggctaaa gggattggga atggctttcc catggcagca gtcataacca ctccagagat    840
 tgccaaatct ttggcgaaat gcctgcagca cttcaacacc tttggaggga accccatggc    900
 ctgtgccatt ggatctgctg tgcttgaggt gattaaagaa gaaaatctac aggaaaacag    960
 tcaagaagtt gggacctaca tgttactaaa gtttgctaag ctgcgggatg aatttgaaat   1020
 tgttggagac gtccgaggca aaggtctcat gataggcata gaaatggtgc aggataagat   1080
 aagctgtcgg cctcttcccc gtgaagaagt aaatcagatc catgaggact gcaagcacat   1140
 gggactcctc gttggcagag gcagcatttt ttctcagaca tttcgcattg cgccctcaat   1200
 gtgcatcact aaaccagaag ttgattttgc agtagaagta tttcgttctg ccttaaccca   1260
 acacatggaa agaagagcta agtaacattg tcagaaataa ataaaaccac aagtctcaag   1320
 aatttgccac gtatgttcaa gggtgaattt gaagaatttc agaaccactg gtatccagag   1380
 aaagcctgca gctntccaca ggagctgtaa aagtcatgtt gctgctacca ccatatgtgt   1440
 acagaccctc ttacgtgaga atcgatgtca gggaagtccc gtactcgaga taatctaata   1500
 gttagtagga tgtattgatc cgttcatgat ggtaccagat aggatgattt gcatgactta   1560
 gaactttggg gaaaaaagag aaaagatata ttgtgttgcg ggtcttgttg tgcgtatgcg   1620
 gacagtccat cntgacatct cgttaaccgc cctaccgatg acgtcgctcg tgtggggacc   1680
 ccgtcttctc cggacggtcc caaacgggct ggtgcggtc                          1719



      <210> 1540
      <211> 1719
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1719)
      <223> n = a,t,c or g


      <400> 1540
 cccggcctcc aatctgcttc catgggggtt ggctttctga gtgggagaaa tgactctaat     60
 ctggagacat ttgctgagac ccttgtgcct ggtcacttcc gctcccagga tccttgagat    120
 gcatcctttc ctgagcctag gtacttcccg gacatcagta accaagctca gtcttcatac    180
 aaagcccaga atgcctccat gtgacttcat gcctgaaaga taccaggtca ttttcttggt    240
 gaacagtggc tcagaagcca atgagctggc catgctgatg gccagggcgc actcaaacaa    300
 catagacatc atttctttca gaggagccta ccatggatgc agtccttaca cacttggctt    360
 gacaaacgta gggatctaca agatggaact ccctggtggg acaggttgcc aaccaacaat    420
 gtgtccagat gtttttcgtg gcccttgggg aggaagccac tgtcgagatt ctccagtgca    480
 aacaatcagg aagtgcagct gtgcaccaga ctgctgccaa gctaaagatc agtatattga    540
 gcaattcaaa gatacgctga gcacatctgt ggccaagtca attgctggat ttttcgcaga    600
 acctattcaa ggtgtgaatg gagttgtcca gtacccaaag gggtttctaa aggaagcctt    660
 tgagctggtg cgagcaaggg gaggcgtgtg cattgcaaat gaagtgcaga caggatttgg    720
 aaggttgggc tctcacttct ggggcttcca aacccacgat gtcctgcctg acattgtcac    780
 catggctaaa gggattggga atggctttcc catggcagca gtcataacca ctccagagat    840
 tgccaaatct ttggcgaaat gcctgcagca cttcaacacc tttggaggga accccatggc    900
 ctgtgccatt ggatctgctg tgcttgaggt gattaaagaa gaaaatctac aggaaaacag    960
 tcaagaagtt gggacctaca tgttactaaa gtttgctaag ctgcgggatg aatttgaaat   1020
 tgttggagac gtccgaggca aaggtctcat gataggcata gaaatggtgc aggataagat   1080
 aagctgtcgg cctcttcccc gtgaagaagt aaatcagatc catgaggact gcaagcacat   1140
 gggactcctc gttggcagag gcagcatttt ttctcagaca tttcgcattg cgccctcaat   1200
 gtgcatcact aaaccagaag ttgattttgc agtagaagta tttcgttctg ccttaaccca   1260
 acacatggaa agaagagcta agtaacattg tcagaaataa ataaaaccac aagtctcaag   1320
 aatttgccac gtatgttcaa gggtgaattt gaagaatttc agaaccactg gtatccagag   1380
 aaagcctgca gctntccaca ggagctgtaa aagtcatgtt gctgctacca ccatatgtgt   1440
 acagaccctc ttacgtgaga atcgatgtca gggaagtccc gtactcgaga taatctaata   1500
 gttagtagga tgtattgatc cgttcatgat ggtaccagat aggatgattt gcatgactta   1560
 gaactttggg gaaaaaagag aaaagatata ttgtgttgcg ggtcttgttg tgcgtatgcg   1620
 gacagtccat cntgacatct cgttaaccgc cctaccgatg acgtcgctcg tgtggggacc   1680
 ccgtcttctc cggacggtcc caaacgggct ggtgcggtc                          1719



      <210> 1541
      <211> 362
      <212> DNA
      <213> Homo sapiens


      <400> 1541
 tggaaggcaa acctgcttct gctatcgtgg gaggcaaacc tgcaaacatc ttggagttcc     60
 cctggcatgt ggggattatg aatcatggta gtcatctctg tgggggatct attctcaatg    120
 agtggtgggt tctatctgca tcccattgct tcgaccaact aaacaactct aaattggaga    180
 tcattcatgg cactgaagac ctcagcacaa agggcataaa gtatcagaaa gtggacaagt    240
 tattcttgca cccaaagttt gatgactggc tcctggacaa cgacatagct ttgctcttgc    300
 tcaaatcccc attaaacttg agtgtcaaca ggatacctat ctgcacttca gaaatctctg    360
 ac                                                                   362



      <210> 1542
      <211> 1839
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1839)
      <223> n = a,t,c or g


      <400> 1542
 gagattgcaa acctcatctt ggctgagaac tgcgaggctg ccctggctct tcatctctat     60
 aggggaggca ggcttttgca aggccaccga atcccttttg gagtcatctt tggtggaact    120
 gatgtaaatg aagatgccaa ccaggcggaa aaaaacacag tcatgggcag agttcttgag    180
 gaagccagat ttgctgtcgc tttcacagag tcaatgaagg aaatggcaca agcgcagtgg    240
 gtcgatccag tgtttacaag ggaagtgaaa gccaaagtga aaagagccgc tggggtacga    300
 ttgattggag agatgcctca agaagatctg cacgcggtgg tgaagaattg cttcgcggtg    360
 gtgaatagct ctgtctctga aggcatgtca gctgcaattt tggaggcaat ggatttagaa    420
 gtaccggtat tggccaggaa catccccggg aatgctgccg tggtgaagca tgaagtcaca    480
 gggctactgt tttccaatcc tcaggagttt gttcatctgg caaagagact ggttagtgat    540
 cctgcattag aaaaggaaat cgtagtgaac ggaagggaat acgtgagaat gtatcattca    600
 tggcaggtgg aaagagacac ctaccaacag ctcatcagga agctggaagg aagcactgaa    660
 gattgagggc cccgcctcat cagacacctg ctctctgaca cacagctctg ggtgcacact    720
 cagagacaga gttctggatc acgtgggccc agtgcagttc aaataaaacc agcctcagcg    780
 gaatcctaga aaatgttagt cgtgagtccc cagagccact gcattcatcc catatccttc    840
 tgtgcgttca gatgctgtcc caggcgtgtt caccagccag tcctgatgga ggtgcatgag    900
 tgactgggtt gactgggaca gggaaagggg aactggtttt cagggaattt gggagagaat    960
 ttgattacct gccttagggc tttggtgtgg acaatagagg cttattttca agcagtcatg   1020
 gttcagactc ctcccgcctg ccttctgacc aacctctccc catcgttgcc agtttgaaag   1080
 gcaaaagcaa aacagacgtg tcagctgagc cgagtcctcg caggattttt gttgtgatct   1140
 caggactctg acaggcacgt gggtgacccg aggcttctct gaacactaga aagcgctgtg   1200
 agtgagctca cgcccggcac agctcacttt tcaatggtgg aattgaaagt tgtgcttttt   1260
 agaaaagtgg ccaggctgcc cgcaggcccc gcccacctct tggctgaatt tgagtggaaa   1320
 accaggaagg aacaagcgcc acgtcacgca tagcctgcaa atcgcccgcg tgaccctgag   1380
 atggaggcct gaggctttgg gtccagggtg ggctcttccc cttcccacat cagggacccg   1440
 gggatggatg tcggaagggt caccagcctc cagcctttgg caggatggag cttgggtctg   1500
 cagggctttg cagccacaca gcgaggtcag tccggggcca gccgcgccat catggtaatg   1560
 gtggcctcgc cccatccatg tcatccatgt cacatgagga cgtgcagtct ttccttgttc   1620
 cttttcctta gtgggaattt tgcctgggga gaacctccac ttgaataatt gaaatttttt   1680
 tgcattgcct gttgggattt cctttacgga caatgggggg aacgcggtgt ttcccacctc   1740
 ttgtgggtag aaagcagtct gctttgagga ggcgagaagg caaagcangg ggcaggggct   1800
 ttgctgtggg aagcgttcgg tgaaagcggg tttcgacgc                          1839



      <210> 1543
      <211> 2161
      <212> DNA
      <213> Homo sapiens


      <400> 1543
 ggcggcgatg tcgctcgtgc tgctaagcct ggccgcgctg tgcaggagcg ccgtaccccg     60
 agagccgacc gttcaatgtg gctctgaaac tgggccatct ccagagtgga tgctacaaca    120
 tgatctaatc ccgggagact tgagggacct ccgagtagaa cctgttacaa ctagtgttgc    180
 aacaggggac tattcaattt tgatgaatgt aagctgggta ctccgggcag atgccagcat    240
 ccgcttgttg aaggccacca agatttgtgt gacgggcaaa agcaacttcc agtcctacag    300
 ctgtgtgagg tgcaattaca cagaggcctt ccagactcag accagaccct ctggtggtaa    360
 atggacattt tcctacatcg gcttccctgt agagctgaac acagtctatt tcattggggc    420
 ccataatatt cctaatgcaa atatgaatga agatggccct tccatgtctg tgaatttcac    480
 ctcaccaggc tgcctagacc acataatgaa atataaaaaa aagtgtgtca aggccggaag    540
 cctgtgggat ccgaacatca ctgcttgtaa gaagaatgag gagacagtag aagtgaactt    600
 cacaaccact cccctgggaa acagatacat ggctcttatc caacacagca ctatcatcgg    660
 gttttctcag gtgtttgagc cacaccagaa gaaacaaacg cgagcttcag tggtgattcc    720
 agtgactggg gatagtgaag gtgctacggt gcagctgact ccatattttc ctacttgtgg    780
 cagcgactgc atccgacata aaggaacagt tgtgctctgc ccacaaacag gcgtcccttt    840
 ccctctggat aacaacaaaa gcaagccggg aggctggctg cctctcctcc tgctgtctct    900
 gctggtggcc acatgggtgc tggtggcagg gatctatcta atgtggaggc acgaaaggat    960
 caagaagact tccttttcta ccaccacact actgcccccc attaaggttc ttgtggttta   1020
 cccatctgaa atatgtttcc atcacacaat ttgttacttc actgaatttc ttcaaaacca   1080
 ttgcagaagt gaggtcatcc ttgaaaagtg gcagaaaaag aaaatagcag agatgggtcc   1140
 agtgcagtgg cttgccactc aaaagaaggc agcagacaaa gtcgtcttcc ttctttccaa   1200
 tgacgtcaac agtgtgtgcg atggtacctg tggcaagagc gagggcagtc ccagtgagaa   1260
 ctctcaagac ctcttccccc ttgcctttaa ccttttctgc agtgatctaa gaagccagat   1320
 tcatctgcac aaatacgtgg tggtctactt tagagagatt gatacaaaag acgattacaa   1380
 tgctctcagt gtctgcccca agtaccacct catgaaggat gccactgctt tctgtgcaga   1440
 acttctccat gtcaagcagc aggtgtcagc aggaaaaaga tcacaagcct gccacgatgg   1500
 ctgctgctcc ttgtagccca cccatgagaa gcaagagacc ttaaaggctt cctatcccac   1560
 caattacagg gaaaaaacgt gtgatgatcc tgaagcttac tatgcagcct acaaacagcc   1620
 ttagtaatta aaacatttta taccaataaa attttcaaat attgctaact aatgtagcat   1680
 taactaacga ttggaaacta catttacaac ttcaaagctg ttttatacat agaaatcaat   1740
 tacagtttta attgaaaact ataaccattt tgataatgca acaataaagc atcttcagcc   1800
 aaacatctag tcttccatag accatgcatt gcagtgtacc cagaactgtt tagctaatat   1860
 tctatgttta attaatgaat actaactcta agaacccctc actgattcac tcaatagcat   1920
 cttaagtgaa aaaccttcta ttacatgcaa aaaatcattg tttttaagat aacaaaagta   1980
 gggaataaac aagctgaacc cacttttact ggaccaaatg atctattata tgtgtaacca   2040
 cttgtatgat ttggtatttg cataagacct tccctctaca aactagattc atatcttgat   2100
 tcttgtacag gtgcctttta acatgaacaa caaaataccc acaaacttgt ctacttttgc   2160
 c                                                                   2161



      <210> 1544
      <211> 622
      <212> DNA
      <213> Homo sapiens


      <400> 1544
 cctgacccct gcctgaatgg aggctcttgt gttgacctag tggggaatta cacctgcttg     60
 tgtgccgagc ccttcaaggg acttcgctgt gagacaggag accatccagt gccagacgcc    120
 tgcctctcgg ccccttgcca caatgggggc acctgtgtgg atgcggacca gggctacgtg    180
 tgcgagtacc ccgaaggctt catgggcctg gactgcaggg agagagtccc cgatgactgt    240
 gagtgccgca acggaggcag atgcctgggc gccaacacca ccctctgcca gtgccccctg    300
 ggattctttg ggcttctctg tgaatttgaa atcacagcca tgccctgcaa catgaacaca    360
 cagtgcccag atgggggcta ctgcatggag cacggcggga gctacctctg ccagtgcccc    420
 ctgggattct ttgggcttct ctgtgaattt gaaatcacag ccatgccctg caacatgaac    480
 acacagtgcc cagatggggg ctactgcatg gagcacggcg ggagctacct ctgcgtctgc    540
 cacaccgacc acaatgccag ccactccctg ccatcaccct gcgactcgga cccctcctcg    600
 tgccaagctt ggcgtaatga ga                                             622



      <210> 1545
      <211> 325
      <212> DNA
      <213> Homo sapiens


      <400> 1545
 ttccagccat gaatgtcaat gactcagtca ccaaacagaa atttgacaac ctctactgtt     60
 gccgtgaatc aattcttgat gggtaatgtt tattatcttt gagatgaagt tgtgatgtcc    120
 agttgagatt ctaagttttt tggctttggt tatttctgga aaggattcat gtagcacctc    180
 tggataatgt ctccataaag ccagagcttt gtcacctcgt aaattaaaat tacattattt    240
 ttattttctc ctttgtatct tttctatttc taaatattat attttcaaaa tattatctaa    300
 taaatgtatg ttgcttttat gttta                                          325



      <210> 1546
      <211> 1255
      <212> DNA
      <213> Homo sapiens


      <400> 1546
 ccatgttggc cagagccacc gcattatttt tcagccaggt gcagtggctc acacctgtaa     60
 ccccgcactt tgggaggcca aggtgggtgg atcacctgaa gttgggagtt tgagaccagc    120
 ccgatcaact ttgaagaaac cgtctctact aaaaatgcaa aaacctagcc gggcgtggtg    180
 gcacgtgcct gtaatcccag ctactcggga ggctgaggca agaggatggc ttgaactcgg    240
 gaggcagagg ttgtggtgag ccgagatcac ggcactgcac tccagcctgg gtgacaagag    300
 caagactccg tctcaaaata aataaataaa aataaaaaat aaacatgatg atcacagatg    360
 cagtcacatt ttctgagttc ttgtctctct gccagtgcca cccagatagc ctcacaaaac    420
 tttgacccag ccactgttag tgtcgccacc gcccataaag gagctgagcc cagcaggggc    480
 actgcctggg gccctgtagc caaaaggcta cagcaggagc tgatgaccct catgatgcct    540
 ggtgacaaaa gaatttctgc ctaccctgaa agccttatca aatggacacc atccatgaag    600
 cagctggcac agtgtatgaa gatctgaggt ataagctctt gctggagttc ctcaatgact    660
 acccaccttt acgatgcacc cacagtgaag ttcctcacac cctgctacca ccctaacgtg    720
 gacacccagg gtaacatatg cctggacatc ctgaaggaga agtggtctgc cccgtatgat    780
 atcaggacca tcctgctctc tatccagtgc ctgctaggac aactcaacat tgatagccct    840
 ttgaacacac atgctaccaa gctctgggaa aaccccatag ctttaagaag tacctgcaag    900
 ggtcaggcgc agtggctcac acctgtaatc ccagcacttt gggaggccga ggtgggtgga    960
 tggatcacct gacgtagaga gtccaaggcc tgacaaacat ggagaaatgt catccctatt   1020
 taaaaaaata aaaaaattag ccaagtgtgg tggcgcatgc ctgtaatccc agctactcgg   1080
 gaggctgagg caggagaatc acttgaacct gggaggtgga ggttgcagtg agccgagatc   1140
 tcgctattgc actccagcct gggcaacaag agtgaaactc tgcctcaaaa aaaagttata   1200
 taaaataaaa atataaataa ggaagtacct gcaagaaagc tactcaaagt aggtc        1255



      <210> 1547
      <211> 1576
      <212> DNA
      <213> Homo sapiens


      <400> 1547
 gatgtatggt ctgccctggg cttgtctgtt ccctcctgag cctgagcccc ttaccttcct     60
 gaccccatga agcacacact ggctctgctg gctcccctgc tgggcctggg cctggggctg    120
 gccctgagtc agctggctgc aggggccaca gactgcaagt tccttggccc ggcagagcac    180
 ctgacattca ccccagcagc cagggcccgg tggctggccc ctcgagttcg tgcgccagga    240
 ctcctggact ccctctatgg caccgtgcgc cgcttcctct cggtggtgca gctcaatcct    300
 ttcccttcag agttggtaaa ggccctactg aatgagctgg cctccgtgaa ggtgaatgag    360
 gtggtgcggt acgaggcggg ctacgtggta tgcgctgtga tcgcgggcct ctacctgctg    420
 ctggtgccca ctgccgggct ttgcttctgc tgctgccgct gccaccggcg ctgcggggga    480
 cgagtgaaga cagagcacaa ggcgctggcc tgtgagcgcg cggccctcat ggtcttcctg    540
 ctgctgacca ccctcttgct gctgattggt gtggtctgtg cctttgtcac caaccagcgc    600
 acgcatgaac agatgggccc cagcatcgag gccatgcctg agaccctgct cagcctctgg    660
 ggcctggtct ctgatgtccc ccaagtgttg gtgtgagcat tgggagcgcg atccacactc    720
 agctcaggag ctccgtgtac cccttgcttg gcggccgtgg gcagtttggg ccaggtcctg    780
 caggtctccg tgcaccacct gcaaaccttg aatgctacag tggtagagct gcaggccggg    840
 cagcaggacc tggagccagc catccgggaa caccgggacc gcctccttga gctgctgcag    900
 gaggccaggt gccctctgtg gaccatgtcc tgcaccagct aaaaggtgtc cccgaggcca    960
 acttctccag catggtccag gaggagaaca gcaccttcaa cgcccttcca gccctggctg   1020
 ccatgcagac atccagcgtg gtgcaagagc tgaagaaggc agtggcccag cagccggaag   1080
 gggtgaggac actggctgaa gggttcccgg gcttggaggc agcttcccgc tgggcccagg   1140
 cactgcagga ggtggaggag agcagccgcc cctacctgca ggaggtgcag agatacgaga   1200
 cctacaggtg gatcgtgggc tgcgtgctgt gctccgtggt cctattcgtg gtgctctgca   1260
 acctgctggg cctcaatctg ggcatctggg gcctgtctgc cagggacgac cccagccacc   1320
 cagaagccaa gggcgaggct ggagcccgct tcctcatggc aggtgtgggc ctcagcttcc   1380
 tctttgctgc acccctcatc ctcctggtgt tcgccacctt cctggtgggt ggcaacgtgc   1440
 agacgctggt gtgccagagc tgggagaacg gcgagctctt tgagtttgca gacaccccag   1500
 ggaacctgcc cccgtccatg aacctgtcgc aacttcttgg cctgaggaag aacatcagca   1560
 tccaccaagc ctatca                                                   1576



      <210> 1548
      <211> 1069
      <212> DNA
      <213> Homo sapiens


      <400> 1548
 ctgatcttaa ggataccatt ggctctgtca ccaaaacacc gagtggttta tacataattc     60
 acccagaagg atctagctac ccatttgagg taatgtgtga catggattac agaggaggtg    120
 gatggactgt gatacagaaa agaattgatg ggataattga tttccagagg ttgtggtgtg    180
 attatctgga tggatttgga gatcttctag gagaattttg gctaggactg aaaaagattt    240
 tttatatagt aaatcagaaa aataccagtt ttatgctgta tgtggctttg gaatctgaag    300
 atgacactct tgcttatgca tcatatgata atttttggct agaggatgaa acgagatttt    360
 ttaaaatgca cttaggacgg tattcaggaa atgctggtga tgcattccgg ggtctcaaaa    420
 aagaagataa tcaaaatgca atgcctttta gcacatcaga tgttgataat gatgggtgtc    480
 gccctgcatg cctggtcaat ggtcagtctg tgaagagctg cagtcacctc cataacaaga    540
 ccggctggtg gtttaacgag tgtggtctag caaatctaaa tggcattcat cacttctctg    600
 gaaaattgct tgcaactgga attcaatggg gcacgtggac caaaaacaac tcacctgtca    660
 agattaaatc tgtttcaatg aaaattagaa gaatgtacaa tccatatttt aaataatctc    720
 atttaacatt gtaatgcaag ttctacaatg ataatatatt aaagattttt aaaagtttat    780
 cttttcactt agtgtttcaa acatattagg caaaatttaa ctgtagatgg catttagatg    840
 ttatgagttt aattagaaaa cttcaatttt gtagtattct ataaaagaaa acatggctta    900
 ttgtatgttt ttacttctga ctatattaac aatatacaat gaaatttgtt tcaagtgaac    960
 tacaacttgt cttcctaaaa tttatagtga ttttaaagga ttttgccttt tctttgaagc   1020
 atttttaaac cataatatgt tgtaaggaaa attgaaggga atattttac               1069



      <210> 1549
      <211> 1069
      <212> DNA
      <213> Homo sapiens


      <400> 1549
 ctgatcttaa ggataccatt ggctctgtca ccaaaacacc gagtggttta tacataattc     60
 acccagaagg atctagctac ccatttgagg taatgtgtga catggattac agaggaggtg    120
 gatggactgt gatacagaaa agaattgatg ggataattga tttccagagg ttgtggtgtg    180
 attatctgga tggatttgga gatcttctag gagaattttg gctaggactg aaaaagattt    240
 tttatatagt aaatcagaaa aataccagtt ttatgctgta tgtggctttg gaatctgaag    300
 atgacactct tgcttatgca tcatatgata atttttggct agaggatgaa acgagatttt    360
 ttaaaatgca cttaggacgg tattcaggaa atgctggtga tgcattccgg ggtctcaaaa    420
 aagaagataa tcaaaatgca atgcctttta gcacatcaga tgttgataat gatgggtgtc    480
 gccctgcatg cctggtcaat ggtcagtctg tgaagagctg cagtcacctc cataacaaga    540
 ccggctggtg gtttaacgag tgtggtctag caaatctaaa tggcattcat cacttctctg    600
 gaaaattgct tgcaactgga attcaatggg gcacgtggac caaaaacaac tcacctgtca    660
 agattaaatc tgtttcaatg aaaattagaa gaatgtacaa tccatatttt aaataatctc    720
 atttaacatt gtaatgcaag ttctacaatg ataatatatt aaagattttt aaaagtttat    780
 cttttcactt agtgtttcaa acatattagg caaaatttaa ctgtagatgg catttagatg    840
 ttatgagttt aattagaaaa cttcaatttt gtagtattct ataaaagaaa acatggctta    900
 ttgtatgttt ttacttctga ctatattaac aatatacaat gaaatttgtt tcaagtgaac    960
 tacaacttgt cttcctaaaa tttatagtga ttttaaagga ttttgccttt tctttgaagc   1020
 atttttaaac cataatatgt tgtaaggaaa attgaaggga atattttac               1069



      <210> 1550
      <211> 1069
      <212> DNA
      <213> Homo sapiens


      <400> 1550
 ctgatcttaa ggataccatt ggctctgtca ccaaaacacc gagtggttta tacataattc     60
 acccagaagg atctagctac ccatttgagg taatgtgtga catggattac agaggaggtg    120
 gatggactgt gatacagaaa agaattgatg ggataattga tttccagagg ttgtggtgtg    180
 attatctgga tggatttgga gatcttctag gagaattttg gctaggactg aaaaagattt    240
 tttatatagt aaatcagaaa aataccagtt ttatgctgta tgtggctttg gaatctgaag    300
 atgacactct tgcttatgca tcatatgata atttttggct agaggatgaa acgagatttt    360
 ttaaaatgca cttaggacgg tattcaggaa atgctggtga tgcattccgg ggtctcaaaa    420
 aagaagataa tcaaaatgca atgcctttta gcacatcaga tgttgataat gatgggtgtc    480
 gccctgcatg cctggtcaat ggtcagtctg tgaagagctg cagtcacctc cataacaaga    540
 ccggctggtg gtttaacgag tgtggtctag caaatctaaa tggcattcat cacttctctg    600
 gaaaattgct tgcaactgga attcaatggg gcacgtggac caaaaacaac tcacctgtca    660
 agattaaatc tgtttcaatg aaaattagaa gaatgtacaa tccatatttt aaataatctc    720
 atttaacatt gtaatgcaag ttctacaatg ataatatatt aaagattttt aaaagtttat    780
 cttttcactt agtgtttcaa acatattagg caaaatttaa ctgtagatgg catttagatg    840
 ttatgagttt aattagaaaa cttcaatttt gtagtattct ataaaagaaa acatggctta    900
 ttgtatgttt ttacttctga ctatattaac aatatacaat gaaatttgtt tcaagtgaac    960
 tacaacttgt cttcctaaaa tttatagtga ttttaaagga ttttgccttt tctttgaagc   1020
 atttttaaac cataatatgt tgtaaggaaa attgaaggga atattttac               1069



      <210> 1551
      <211> 1565
      <212> DNA
      <213> Homo sapiens


      <400> 1551
 ttttttttca attaatttca gcagcatctt tattgcaaca aagaacctgt aataaaatgc     60
 aagaaaacta atgtttccct ttacatgatt aaaagccata tacctaaaaa tgagaaaacc    120
 cataagctta ctggagacat gcaattcttt ttatacaagt caatgcttaa aacagcaggc    180
 acttcatgtt ctaaaattaa acacctgaat tccaattttg ctgaatacaa tataaatttg    240
 ttttggggtt acttaaaaac aaacatacaa accctacttt ttctttatct gtaaaggact    300
 tatgaaatga tcacctagag cccaggacct tgcactaaca tctctatatt tgaggctgga    360
 agatggctag gtgaggctgg gaaggtggga atcaaaaaag tttccttttt cctttatatc    420
 tgctgggaat agacacactc accttatata gtttagaaat ggccatgtct cttttcttac    480
 atcaaatagc tataaagatg ggctcccagg cttaagcaag cactctactc tatattccaa    540
 tcctcaaatc ctccactata ccaaggaaga cacatttagt gcaatgagtt taattaactt    600
 cagaatgtca tatactaatc agaagtactg cttcattaat aaacatgctt agcatttact    660
 ttggaatgga aaaattaacc atttttatgt ggttaccttt aaaatgtttt ataggaatat    720
 attaataaat atttctttaa aaatttacct tttctatata tcatttaact accatgaggc    780
 aggacacctg gctggagtcc agcaccaact ggatactaac tggctgtgtg gtcgtgggta    840
 tatttcctcc tctctctcta gcatgtaggt tgttcttcta acaaatgaga atatcagctt    900
 agattaaatc aaagattgat tccatcttga aaaatgcatg atttaataat gagaaatctt    960
 ataggaatca ttccacctaa agagaactat gctatagaaa ggcgggctat actttcctgg   1020
 aaggaataaa acaagtagta aaaaaaaaaa aaagtaagca tcggtatcaa tatcgcattc   1080
 ttttaaaagg taatgcatgc attgtgacct aatcctcttg tatgaggctt tggaaaagaa   1140
 cccaggaatg gcatagagag aaaaactttc attccaaaat taatctccag acaaagggga   1200
 tagaaacaaa gtaaacaaca tctcctgctg ctttcagagt gagacggggc caaatagtta   1260
 ccacagatga gcagcttcat ggactactgt ttaggttctt gtgaatcagt ccagtgtaaa   1320
 aaatcaccta ttattaatcc aactccattc tctatagaag agtttcttaa agtagtccac   1380
 agatgactta ctataggatc gcctggaaag cttgttagaa atgcacattc ctggtgtcta   1440
 cccaaatcaa tggaatacaa atttttattt atttatttat tttgaggcag aatctcactc   1500
 tgtcgcccag actggactac agtagcgcca tctcggctca ctgcaacttc cgcctcccca   1560
 ggttc                                                               1565



      <210> 1552
      <211> 943
      <212> DNA
      <213> Homo sapiens


      <400> 1552
 tttttttttt ttagaaataa atcattttaa tgtctatttt ttcacttcta ttaattgatt     60
 attgatttct acacaagtgt atgcatctag tttgacttgc ttcatattta ttttccaaca    120
 tggtgcaatc ttcagcatga ggtgcacgaa gtaccttgtc ctcaaagagc tttatcaact    180
 cgaacatttt cgaagagctc tataaggcag ctcagcatgg cagtttttta ctgaaatctc    240
 ttatctggaa gatggcagaa gagacccgga ccttcccgag cccactggtt gcttgtattc    300
 atatcacagc tcgcttgagt aagtggtaac gacagaataa taagcagatt gctcctccaa    360
 acccagctgg gtgagatagc ttcatttttg gaaaatcaac tgaatcatga aaaccttcct    420
 aatggtataa tttgttccag agttcttttg atacttaaga agggaaatat taatccttgt    480
 gcacagtctt ttattacaag cactcttatt tatggtatta cagagttttc ttctccagcc    540
 gtcattctct ggtgaggtga ctggctgtac cccatgcaga atcgaaagca tgaagaaatc    600
 tcctttctta atcagagctg atgacagccc tctcatttcc tgccaaatgg atcagaccac    660
 acttttaacc ctggtggctg cacatcctct tgaacaattc cagcccgatt tatagcttgt    720
 tccttcttgt actcctccaa tctcattagg ggccggaagt agatgggata gaaggcggcg    780
 ccgatcaggg agatgaagcc gccgaaaatg agcgcggtgc gcaggttccg ggacatggcg    840
 tcaggccccg ggctgccctg acccgccgac cgcccggcac tctcggaaac caggttaccg    900
 acggccgggc cgtgaccccg ctcggaagag gtggagaggc ttt                      943



      <210> 1553
      <211> 1958
      <212> DNA
      <213> Homo sapiens


      <400> 1553
 caattcccgg gtcgacgatt tcgttttccc tctgttttat ttttcccccg tgtgtcccta     60
 ctatggtcag aaagcctgtt gtgtccacca tctccaaagg aggttacctg cagggaaatg    120
 ttaacgggag gctgccttcc ctgggcaaca aggagccacc tgggcaggag aaagtgcagc    180
 tgaagaggaa agtcacttta ctgaggggag tctccattat cattggcacc atcattggag    240
 caggaatctt catctctcct aagggcgtgc tccagaacac gggcagcgtg ggcatgtctc    300
 tgaccatctg gacggtgtgt ggggtcctgt cactatttgg agctttgtct tatgctgaat    360
 tgggaacaac tataaagaaa tctggaggtc attacacata tattttggaa gtctttggtc    420
 cattaccagc ttttgtacga gtctgggtgg aactcctcat aatacgccct gcagctactg    480
 ctgtgatatc cctggcattt ggacgctaca ttctggaacc attttttatt caatgtgaaa    540
 tccctgaact tgcgatcaag ctcattacag ctgtgggcat aactgtagtg atggtcctaa    600
 atagcatgag tgtcagctgg agcgcccgga tccagatttt cttaaccttt tgcaagctca    660
 cagcaattct gataattata gtccctggag ttatgcagct aattaaaggt caaacgcaga    720
 actttaaaga cgccttttca ggaagagatt caagtattac gcggttgcca ctggcttttt    780
 attatggaat gtatgcatat gctggctggt tttacctcaa ctttgttact gaagaagtag    840
 aaaaccctga aaaaaccatt ccccttgcaa tatgtatatc catggccatt gtcaccattg    900
 gctatgtgct gacaaatgtg gcctacttta cgaccattaa tgctgaggag ctgctgcttt    960
 caaatgcagt ggcagtgacc ttttctgagc ggctactggg aaatttctca ttagcagttc   1020
 cgatctttgt tgccctctcc tgctttggct ccatgaacgg tggtgtgttt gctgtctcca   1080
 ggttattcta tgttgcgtct cgagagggtc accttccaga aatcctctcc atgattcatg   1140
 tccgcaagca cactcctcta ccagctgtta ttgttttgca ccctttgaca atgataatgc   1200
 tcttctctgg agacctcgac agtcttttga atttcctcag ttttgccagg tggcttttta   1260
 ttgggctggc agttgctggg ctgatttatc ttcgatacaa atgcccagat atgcatcgtc   1320
 ctttcaaggt gccactgttc atcccagctt tgttttcctt cacatgcctc ttcatggttg   1380
 ccctttccct ctattcggac ccatttagta cagggattgg cttcgtcatc actctgactg   1440
 gagtccctgc gtattatctc tttattatat gggacaagaa acccaggtgg tttagaataa   1500
 tgtcagagaa aataaccaga acattacaaa taatactgga agttgtccca gaagaagata   1560
 agttatgaac taatggactt gagatcttgg caatctgccc aaggggagac acaaaatagg   1620
 gatttttact tcattttctg aaagtctaga gaattacaac tttggtgata aacaaaagga   1680
 gtcagttatt tttattcata tattttagca tattcgaact aatttctaag aaatttagtt   1740
 ataactctat gtagttatag aaagtgaata tgcagttatt ctatgagtcg cacaattctt   1800
 gagtctctga tacctaccta ttggggttag gagaaaagac tagacaatta ctatgtggtc   1860
 attctctaca acatatgtta gcacggcaaa gaaccttcaa attgaagact gagatttttc   1920
 tgtatatatg ggttttggaa agatggtttt acacacta                           1958



      <210> 1554
      <211> 708
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(708)
      <223> n = a,t,c or g


      <400> 1554
 cttacctaaa gaacctacct gaacctagat atatagacaa aatagaacta aagatgaaga     60
 taagcctcca aaatccagaa tgggacttgc cagacactat cgggtgacca accacctgaa    120
 ataattcttg gccttcccag tcagtcttcc ttcagtatcc ttggttttat ttgtagttac    180
 ttttaaacag ctagtccttg aaaaagctat tcatagaaaa acctctttta cagcttgtcc    240
 ttgatctgtt cttcttaccc ttctatttta gaccacattg tgcacattat agagctgata    300
 ggcagaattc caagacgctt ttccctcagt gggaaatatt cacaagactt cttcagtcac    360
 agaggtagta ttgttatgta ggacccaggg atacttcagg aagcagagca ttcacaccaa    420
 gattgttttt agttatcact gaatccacaa aaatttgact ttgtgaattc tccattagat    480
 ggatagagtc ttcctcttcc catttaggat agaaagtaag cctgataggc tttacaaaga    540
 gatgtgcatg ctgctccttc tgctgttttc tagagctgca tttgttactc ttgttacgga    600
 tctttttttt ctcgaaccga cttgttggcc tctagggccc tctaccccat agtgcctcgt    660
 agtgattcgt agtcatgtca taacggttta ctacggtntc gagggggg                 708



      <210> 1555
      <211> 4686
      <212> DNA
      <213> Homo sapiens


      <400> 1555
 gtggactgtg cattgtcact tattcgactt gggatggagc ggaatattcc tggtttgctg     60
 gttctctgtg acaatttggt tactctggaa acattggttt atgaagccag gtgtgatgta    120
 actctaaccc tgaaagaact ccagcagatg aaagacattg aaaaactaag attactgatg    180
 aatagttgtt ctgaggataa atatgtgaca agtgcctacc agtggatggt tccctttctt    240
 catcgttgtg agaaacagtc gcctggtgtg gctaatgagc tattaaaaga atatttagta    300
 actttagcta aaggggactt aaaatttccc ctgaagatat ttcagcattc caaaccagat    360
 ctgcagcaaa aaattattcc tgatcaggac caactgatgg caatagcact agagtgcatc    420
 tatacctgtg aacgaaatga tcaactctgt ctttgctatg acctactaga atgtctgcca    480
 gaaagaggat atggtgataa gacagaggca accacaaagc ttcatgacat ggtagaccaa    540
 ctggaacaaa ttctcagtgt gtcagagctt ttggaaaaac atggactcga gaaaccaatt    600
 tcatttgtta aaaacactca atctagctca gaagaggcac gcaagctgat ggttagattg    660
 acgaggcaca ctggccggaa gcagcctcct gtcagtgagt ctcattggag aacgttgctg    720
 caagacatgt taactatgca gcagaatgta tacacatgtc tagattctga tgcctgctat    780
 gagatattta cagaaagcct tctgtgctct agtcgccttg aaaacatcca cctggctgga    840
 cagatgatgc actgcagtgc ttgttcagaa aatcctccag ctggtatagc ccataaaggg    900
 aaaccccact acagggtcag ctacgaaaag agtattgact tggttttggc tgccagcaga    960
 gagtacttca attcttctac caacctcact gatagctgca tggatctagc caggtgctgc   1020
 ttacaactga taacagacag accccctgcc attcaagagg agctagatct tatccaagcc   1080
 gttggatgtc ttgaagaatt tggggtagag atcctgcctt tgcaagtgcg attgtgccct   1140
 gatcggatca gtctcatcaa ggagtgtatt tcccagtccc ccacatgcta taaacaatcc   1200
 accaagcttc tgggccttgc tgagctgctg agggttgcag gtgagaaccc agaagaaagg   1260
 cggggacagg ttctaatcct tttagtggag caggcacttc gcttccatga ctacaaagca   1320
 gccagtatgc attgtcagga gctgatggcc acaggttatc ctaaaagttg ggatgtttgt   1380
 agccagttag gacaatcaga aggttaccag gacttggcca ctcgtcaaga gctcatggct   1440
 tttgctttga cacattgccc tcctagcagc attgaacttc ttttggcagc tagcagctct   1500
 ctgcagacag aaattcttta tcaaagagtg aatttccaga tccatcatga aggaggggaa   1560
 aatatcagtg cttcaccatt aactagtaaa gcagtacaag aggatgaagt aggtgttcca   1620
 ggtagcaatt cagctgacct attgcgctgg accactgcta ccaccatgaa agtcctttcc   1680
 aacaccacaa ccaccaccaa agcggtgctg caggccgtca gtgatgggca gtggtggaag   1740
 aagtctttaa cttaccttcg acccccttca ggggcaaaaa tgtggtggtg catatcaaat   1800
 cggaactaca gccaatgaag atctagagaa acaagggtgt catccttttt atgaatctgt   1860
 catctcaaat ccttttgtcg ctgagtctga agggacctat gacacctatc agcatgttcc   1920
 agtggaaagc tttgcagaag tatttgctga gaactggaaa attggcagag gctaaaaata   1980
 aaggagaagt atttccaaca actgaagttc tcttgcaact agcaagtgaa gccttgccaa   2040
 atgacatgac cttggctctt gcttaccttc ttgccttacc acaagtgtta gatgctaacc   2100
 ggtgctttga aaagcagtcc ccctctgcat tatctctcca gctggcagcg tattactata   2160
 gcctccagat ctatgcccga ttggccccat gtttcaggga caagtgccat cctctttaca   2220
 gggctgatcc caaagaacta atcaagatgg tcaccaggca tgtgactcga catgagcacg   2280
 aagcctggcc tgaagacctt atttcactga ccaagcagtt acactgctac aatgaacgtc   2340
 tcctggattt cactcaggcg cagatccttc agggccttcg gaagggtgtg gacgtgcagc   2400
 ggtttactgc agatgaccag tataaaaggg aaactatcct tggtctggca gaaactctag   2460
 aggaaagcgt ctacagcatt gctatttctc tggcacaacg ttacagtgtc tcccgctggg   2520
 aagtttttat gacccatttg gagttcctct tcacggacag tggtttgtcc acactagaaa   2580
 ttgaaaatag agcccaagac cttcatctct ttgagacttt gaagactgat ccagaagcct   2640
 ttcaccagca catggtcaag tatatttacc ctactattgg tggctttgat cacgaaaggc   2700
 tgcagtatta tttcactctt ctggaaaact gtggctgtgc agatttgggg aactgtgcca   2760
 ttaaaccaga aacccacatt cgactgctga agaagtttaa ggttgttgca tcaggtctta   2820
 attacaaaaa gctgacagat gaaaacatga gtcctcttga agcattggag ccagttcttt   2880
 caagtcaaaa tatcttgtct atttccaaac ttgttcccaa aatccctgaa aaggatggac   2940
 agatgctttc cccaagctct ctgtacacca tctggttaca gaagttgttc tggactggag   3000
 accctcatct cattaaacaa gtcccaggct cttcaccgga gtggcttcat gcctatgatg   3060
 tctgcatgaa gtactttgat cgtctccacc caggtgacct catcactgtg gtagatgcag   3120
 ttacattttc tccaaaagct gtgaccaagc tgtctgtgga agcccgtaaa gagatgacta   3180
 gaaaggctat taagacagtc aaacatttta ttgagaagcc aaggaaaaga aactcagaag   3240
 acgaagctca agaagctaag gattctaaag ttacctatgc agatactttg aatcatctgg   3300
 agaaatcact tgcccacctg gaaaccctga gccacagctt catcctttct ctgaagaata   3360
 gtgagcagga aacactgcaa aaatacagtc acctctatga tctgtcccga tcagaaaaag   3420
 agaaacttca tgatgaagct gtggctattt gtttagatgg tcagcctcta gcaatgattc   3480
 agcagctgct agaggtggca gttggccctc ttgacatctc acccaaggat atagtgcaga   3540
 gtgcaatcat gaaaataatt tctgcattga gtggtggcag tgctgacctt ggtgggccaa   3600
 gggacccact gaaggtcctg gaaggtgttg ttgcagcagt ccacgccagt gtggacaagg   3660
 gtgaggagct ggtttcacct gaggacctgc tggagtggct gcggcctttc tgtgctgatg   3720
 acgcctggcc ggtgcggccc cgcattcacg tgctgcagat tttggggcaa tcatttcacc   3780
 tgactgagga ggacagcaag ctcctcgtgt tctttagaac tgaagccatt ctcaaagcct   3840
 cctggcccca gagacaggta gacatagctg acattgagaa tgaagagaac cgctactgtc   3900
 tattcatgga actcctggaa tctagtcacc acgaggctga atttcagcac ttggttttac   3960
 ttttgcaagc ttggccacct atgaaaagtg aatatgtcat aaccaataat ccatgggtga   4020
 gactagctac agtgatgcta accagatgta cgatggagaa caaggaagga ttggggaatg   4080
 aagttttgaa aatgtgtcgc tctttgtata acaccaagca gatgctgcct gcagagggtg   4140
 tgaaggagct gtgtctgctg ctgcttaacc agtccctcct gcttccatct ctgaaacttc   4200
 tcctcgagag ccgagatgag catctgcacg agatggcact ggagcaaatc acggcagtca   4260
 ctacggtgaa tgattccaat tgtgaccaag aacttctttc cctgctcctg gatgccaagc   4320
 tgctggtgaa gtgtgtctcc actcccttct atccacgtat tgttgaccac ctcttggcta   4380
 gcctccagca agggcgctgg gatgcagagg agctgggcag acacctgcgg gaggccggcc   4440
 atgaagccga agccgggtct ctccttctgg ccgtgagggg gactcaccag gccttcagaa   4500
 ccttcagtac agccctccgc gcagcacagc actgggtgtg agggccacct gtggccctgc   4560
 tccttagcag aaaaagcatc tggagttgaa tgctgttccc agaagcaaca tgtgtatctg   4620
 ccgattgttc tccatggttc caacaaattg caaataaaac tgtatggaaa cgatgaaaaa   4680
 aaaaaa                                                              4686



      <210> 1556
      <211> 4686
      <212> DNA
      <213> Homo sapiens


      <400> 1556
 gtggactgtg cattgtcact tattcgactt gggatggagc ggaatattcc tggtttgctg     60
 gttctctgtg acaatttggt tactctggaa acattggttt atgaagccag gtgtgatgta    120
 actctaaccc tgaaagaact ccagcagatg aaagacattg aaaaactaag attactgatg    180
 aatagttgtt ctgaggataa atatgtgaca agtgcctacc agtggatggt tccctttctt    240
 catcgttgtg agaaacagtc gcctggtgtg gctaatgagc tattaaaaga atatttagta    300
 actttagcta aaggggactt aaaatttccc ctgaagatat ttcagcattc caaaccagat    360
 ctgcagcaaa aaattattcc tgatcaggac caactgatgg caatagcact agagtgcatc    420
 tatacctgtg aacgaaatga tcaactctgt ctttgctatg acctactaga atgtctgcca    480
 gaaagaggat atggtgataa gacagaggca accacaaagc ttcatgacat ggtagaccaa    540
 ctggaacaaa ttctcagtgt gtcagagctt ttggaaaaac atggactcga gaaaccaatt    600
 tcatttgtta aaaacactca atctagctca gaagaggcac gcaagctgat ggttagattg    660
 acgaggcaca ctggccggaa gcagcctcct gtcagtgagt ctcattggag aacgttgctg    720
 caagacatgt taactatgca gcagaatgta tacacatgtc tagattctga tgcctgctat    780
 gagatattta cagaaagcct tctgtgctct agtcgccttg aaaacatcca cctggctgga    840
 cagatgatgc actgcagtgc ttgttcagaa aatcctccag ctggtatagc ccataaaggg    900
 aaaccccact acagggtcag ctacgaaaag agtattgact tggttttggc tgccagcaga    960
 gagtacttca attcttctac caacctcact gatagctgca tggatctagc caggtgctgc   1020
 ttacaactga taacagacag accccctgcc attcaagagg agctagatct tatccaagcc   1080
 gttggatgtc ttgaagaatt tggggtagag atcctgcctt tgcaagtgcg attgtgccct   1140
 gatcggatca gtctcatcaa ggagtgtatt tcccagtccc ccacatgcta taaacaatcc   1200
 accaagcttc tgggccttgc tgagctgctg agggttgcag gtgagaaccc agaagaaagg   1260
 cggggacagg ttctaatcct tttagtggag caggcacttc gcttccatga ctacaaagca   1320
 gccagtatgc attgtcagga gctgatggcc acaggttatc ctaaaagttg ggatgtttgt   1380
 agccagttag gacaatcaga aggttaccag gacttggcca ctcgtcaaga gctcatggct   1440
 tttgctttga cacattgccc tcctagcagc attgaacttc ttttggcagc tagcagctct   1500
 ctgcagacag aaattcttta tcaaagagtg aatttccaga tccatcatga aggaggggaa   1560
 aatatcagtg cttcaccatt aactagtaaa gcagtacaag aggatgaagt aggtgttcca   1620
 ggtagcaatt cagctgacct attgcgctgg accactgcta ccaccatgaa agtcctttcc   1680
 aacaccacaa ccaccaccaa agcggtgctg caggccgtca gtgatgggca gtggtggaag   1740
 aagtctttaa cttaccttcg acccccttca ggggcaaaaa tgtggtggtg catatcaaat   1800
 cggaactaca gccaatgaag atctagagaa acaagggtgt catccttttt atgaatctgt   1860
 catctcaaat ccttttgtcg ctgagtctga agggacctat gacacctatc agcatgttcc   1920
 agtggaaagc tttgcagaag tatttgctga gaactggaaa attggcagag gctaaaaata   1980
 aaggagaagt atttccaaca actgaagttc tcttgcaact agcaagtgaa gccttgccaa   2040
 atgacatgac cttggctctt gcttaccttc ttgccttacc acaagtgtta gatgctaacc   2100
 ggtgctttga aaagcagtcc ccctctgcat tatctctcca gctggcagcg tattactata   2160
 gcctccagat ctatgcccga ttggccccat gtttcaggga caagtgccat cctctttaca   2220
 gggctgatcc caaagaacta atcaagatgg tcaccaggca tgtgactcga catgagcacg   2280
 aagcctggcc tgaagacctt atttcactga ccaagcagtt acactgctac aatgaacgtc   2340
 tcctggattt cactcaggcg cagatccttc agggccttcg gaagggtgtg gacgtgcagc   2400
 ggtttactgc agatgaccag tataaaaggg aaactatcct tggtctggca gaaactctag   2460
 aggaaagcgt ctacagcatt gctatttctc tggcacaacg ttacagtgtc tcccgctggg   2520
 aagtttttat gacccatttg gagttcctct tcacggacag tggtttgtcc acactagaaa   2580
 ttgaaaatag agcccaagac cttcatctct ttgagacttt gaagactgat ccagaagcct   2640
 ttcaccagca catggtcaag tatatttacc ctactattgg tggctttgat cacgaaaggc   2700
 tgcagtatta tttcactctt ctggaaaact gtggctgtgc agatttgggg aactgtgcca   2760
 ttaaaccaga aacccacatt cgactgctga agaagtttaa ggttgttgca tcaggtctta   2820
 attacaaaaa gctgacagat gaaaacatga gtcctcttga agcattggag ccagttcttt   2880
 caagtcaaaa tatcttgtct atttccaaac ttgttcccaa aatccctgaa aaggatggac   2940
 agatgctttc cccaagctct ctgtacacca tctggttaca gaagttgttc tggactggag   3000
 accctcatct cattaaacaa gtcccaggct cttcaccgga gtggcttcat gcctatgatg   3060
 tctgcatgaa gtactttgat cgtctccacc caggtgacct catcactgtg gtagatgcag   3120
 ttacattttc tccaaaagct gtgaccaagc tgtctgtgga agcccgtaaa gagatgacta   3180
 gaaaggctat taagacagtc aaacatttta ttgagaagcc aaggaaaaga aactcagaag   3240
 acgaagctca agaagctaag gattctaaag ttacctatgc agatactttg aatcatctgg   3300
 agaaatcact tgcccacctg gaaaccctga gccacagctt catcctttct ctgaagaata   3360
 gtgagcagga aacactgcaa aaatacagtc acctctatga tctgtcccga tcagaaaaag   3420
 agaaacttca tgatgaagct gtggctattt gtttagatgg tcagcctcta gcaatgattc   3480
 agcagctgct agaggtggca gttggccctc ttgacatctc acccaaggat atagtgcaga   3540
 gtgcaatcat gaaaataatt tctgcattga gtggtggcag tgctgacctt ggtgggccaa   3600
 gggacccact gaaggtcctg gaaggtgttg ttgcagcagt ccacgccagt gtggacaagg   3660
 gtgaggagct ggtttcacct gaggacctgc tggagtggct gcggcctttc tgtgctgatg   3720
 acgcctggcc ggtgcggccc cgcattcacg tgctgcagat tttggggcaa tcatttcacc   3780
 tgactgagga ggacagcaag ctcctcgtgt tctttagaac tgaagccatt ctcaaagcct   3840
 cctggcccca gagacaggta gacatagctg acattgagaa tgaagagaac cgctactgtc   3900
 tattcatgga actcctggaa tctagtcacc acgaggctga atttcagcac ttggttttac   3960
 ttttgcaagc ttggccacct atgaaaagtg aatatgtcat aaccaataat ccatgggtga   4020
 gactagctac agtgatgcta accagatgta cgatggagaa caaggaagga ttggggaatg   4080
 aagttttgaa aatgtgtcgc tctttgtata acaccaagca gatgctgcct gcagagggtg   4140
 tgaaggagct gtgtctgctg ctgcttaacc agtccctcct gcttccatct ctgaaacttc   4200
 tcctcgagag ccgagatgag catctgcacg agatggcact ggagcaaatc acggcagtca   4260
 ctacggtgaa tgattccaat tgtgaccaag aacttctttc cctgctcctg gatgccaagc   4320
 tgctggtgaa gtgtgtctcc actcccttct atccacgtat tgttgaccac ctcttggcta   4380
 gcctccagca agggcgctgg gatgcagagg agctgggcag acacctgcgg gaggccggcc   4440
 atgaagccga agccgggtct ctccttctgg ccgtgagggg gactcaccag gccttcagaa   4500
 ccttcagtac agccctccgc gcagcacagc actgggtgtg agggccacct gtggccctgc   4560
 tccttagcag aaaaagcatc tggagttgaa tgctgttccc agaagcaaca tgtgtatctg   4620
 ccgattgttc tccatggttc caacaaattg caaataaaac tgtatggaaa cgatgaaaaa   4680
 aaaaaa                                                              4686



      <210> 1557
      <211> 362
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(362)
      <223> n = a,t,c or g


      <400> 1557
 gcaggagctc gagagaagca tggctcagcg gtgcgtttgc gtgctggccc tggtggctat     60
 gctgctccta gttttcccta ccgtctccag atcgatgggc ccgaggagcg gggagcatca    120
 aagggcgtcg cgaatccctt ctcagttcag caaagaggaa cgcgtcgcga tgaaagaggc    180
 gctgaaagtc tttcctacag tggtcagcac cagctttatc cagcatgaag tcgtggaaga    240
 gtatagccac ctgttcacta tccaaggctc ggaccccagc ttgcagccct acctgctgat    300
 ggctcacttt gatgtggtgc ctgcccctga agaaggctgg gaggtgcccc cattctctgg    360
 gn                                                                   362



      <210> 1558
      <211> 2393
      <212> DNA
      <213> Homo sapiens


      <400> 1558
 gaccaaggag gcgcccgcgg ctgcagagct gcagagcggg atctcttcga gctgtctgtg     60
 tccgggcagc cggcgcgcaa ctgagccaga ggacagcgca tcctttcggc gcgggccggc    120
 agggcccctg cggtcggcaa gctggctccc cgggtggcca ccgggacccc cgagcccaat    180
 ggcgggggcg gcggcaaaat cgacaacact gtagagatca cccccacctc caacggacag    240
 gtcgggaccc tcggagatgc ggtgcccacg gagcagctgc agggtgagcg ggagcgcgag    300
 cgggaggggg agggagacgc gggcggcgac ggactgggca gcagcctgtc gctggccgtg    360
 cccccaggcc ccctcagctt tgaggcgctg ctcgcccagg tgggggcgct gggcggcggc    420
 cagcagctgc agctcggcct ctgctgcctg ccggtgctct tcgtggctct gggcatggcc    480
 tcggacccca tcttcacgct ggcgcccccg ctgcattgcc actacggggc cttcccccct    540
 aatgcctctg gctgggagca gcctcccaat gccagcggcg tcagcgtcgc cagcgctgcc    600
 ctagcagcca gcgccgccag ccgtgtcgcc accaagtacc gaccccctcg tgcagcggct    660
 tcgccccgcc ggacttcaac cattgccctc aaggattggg actataatgg ccttcctgtg    720
 ctcaccacca acgccatcgg ccagtgggat ctggtgtgtg acctgggctg gcaggtgatc    780
 ctggagcaga tcctcttcat cttgggcttt gcctccggct acctgttcct gggttacccc    840
 gcagacagat ttggccgtcg cgggattgtg ctgctgacct tggggctggt gggcccctgt    900
 ggagtaggag gggctgctgc aggctcctcc acaggcgtca tggccctccg attcctcttg    960
 ggctttctgc ttgccggtgt tgacctgggt gtctacctga tgcgcctgga gctgtgcgac   1020
 ccaacccaga ggcttcgggt ggccctggca ggggagttgg tgggggtggg agggcacttc   1080
 ctgttcctgg gcctggccct tgtctctaag gattggcgat tcctacagcg aatgatcacc   1140
 gctccctgca tcctcttcct gttttatggc tggcctggtt tgttcctgga gtccgcacgg   1200
 tggctgatag tgaagcggca gattgaggag gctcagtctg tgctgaggat cctggctgag   1260
 cgaaaccggc cccatgggca gatgctgggg gaggaggccc aggaggccct gcaggacctg   1320
 gagaatacct gccctctccc tgcaacatcc tccttttcct ttgcttccct cctcaactac   1380
 cgcaacatct ggaaaaatct gcttatcctg ggcttcacca acttcattgc ccatgccatt   1440
 cgccactgct accagcctgt gggaggagga gggagcccat cggacttcta cctgtgctct   1500
 ctgctggcca gcggcaccgc agccctggcc tgtgtcttcc tgggggtcac cgtggaccga   1560
 tttggccgcc ggggcatcct tcttctctcc atgaccctta ccggcattgc ttccctggtc   1620
 ctgctgggcc tgtgggatta tctgaacgag gctgccatca ccactttctc tgtccttggg   1680
 ctcttctcct cccaagctgc cgccatcctc agcaccctcc ttgctgctga ggtcatcccc   1740
 accactgtcc ggggccgtgg cctgggcctg atcatggctc taggggcgct tggaggactg   1800
 agcggcccgg cccagcgcct ccacatgggc catggagcct tcctgcagca cgtggtgctg   1860
 gcggcctgcg ccctcctctg cattctcagc attatgctgc tgccggagac caagcgcaag   1920
 ctcctgcccg aggtgctccg ggacggggag ctgtgtcgcc ggccttccct gctgcggcag   1980
 ccacccccta cccgctgtga ccacgtcccg ctgcttgcca cccccaaccc tgccctctga   2040
 gcggcctctg agtaccctgg cgggaggctg gcccacacag aaaggtggca agaagatcgg   2100
 gaagactgag tagggaaggc agggctgccc agaagtctca gaggcacctc acgccagcca   2160
 tcgcggagag ctcagagggc cgtccccacc ctgcctcctc cctgctgctt tgcattcact   2220
 tccttggcca gagtcagggg acagggagag agctccacac tgtaaccact gggtctgggc   2280
 tccatcctgc gcccaaagac atccacccag acctcattat ttcttgctct atcattctgt   2340
 ttcaataaag acatttggaa taaacgagca tatcatagcc tggaaaaaaa aaa          2393



      <210> 1559
      <211> 372
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(372)
      <223> n = a,t,c or g


      <400> 1559
 ncggagtcgg ctgacctgtg aatctggctc tgcacgtgct tgtgggagcc accattgagc     60
 aggagatggt tgctctcctc gcaggccccc ggtccgcggt ctatgatggt ggtgtgctcg    120
 tcctggggcg gcggcgcatc ccccatgctc tccaggagtt cggcctcatt gccaagccac    180
 acccagtcgt gagagtgggt catggaggcc tgaccttcca ggggcacttg cttgtgcctg    240
 tacttcaggg caaaggtggc gcagttgatc aggaagacga ggatggccag gcagaacacc    300
 cccaggaggg cgtacatccc tatctccaga tcactcaggc cccgcggagt ctgcaccagg    360
 tcgttttcct cc                                                        372



      <210> 1560
      <211> 1048
      <212> DNA
      <213> Homo sapiens


      <400> 1560
 cccttctccg agccaggtca ccgcaggggt ctgaaagggc aggggtgggt ggggcttaca     60
 tgctgagcaa ggggtggtgg aaagagggcc gacatggtgg ccacaggcgg cctcggggat    120
 ggggcgcggc tggacgcagg cagtcggtcc ccggtggtcc ggcggctcct catgcactct    180
 gtacagcgtg ggggcggatg ggcgggggca ggggcatcag tctagaggct gcaggcctcc    240
 tggtccaccg agcgcttcct cagctccttg cctggcttgg ggggcggcgg ggcgggcgcg    300
 gcgggagggg cttcgggcag atgcaggacg gagttctccc ctggctgcac ccgcaggtag    360
 gccttgacct tgtggtgccg ggccttgccg tcgctgaagt cgatgacgcg gcactcgtag    420
 gtgccttcgt ccgtgggctt cacccgggac aggcgcagct tgtgggagat gttgctgccc    480
 accaccttga ccacacttat tttggttgcc tccttccctg cgtcttcctg ctgagatgct    540
 tttagctggt tcgaggccca cgcctgcttg tcggtccagt cccggtggct ccgtacatac    600
 caccactgga tctccagcga gtaggagggg gagccgctgc cgcggaagga gcaggccatc    660
 tccacgtcct cgcccgtccg tgctgtcatg tcatggggtg tctctgtgaa cagggcgtgg    720
 ccggagacgt ggttgtccca gggcgcgtgg ccggcgggcc gcgtggcgcc gccgagttgc    780
 aggaaaagtg ccaggtagtg gagggcgccc agcgctacgg cgagcggggc ccccatcgtg    840
 cgctctcggg ccgggggcgc cgccgcctca catctgggcc ccggagaccg cagaaccggc    900
 gccagctgtc ccctgccctg agcggcctgg ctgcccggct ccggcagctg cccctcgccc    960
 gctgtccccg gacccggccc agctcccagc cctcgcccgg ctccggccca gccccggctt   1020
 cggggagcga gcgcacgccc agccggcc                                      1048



      <210> 1561
      <211> 4091
      <212> DNA
      <213> Homo sapiens


      <400> 1561
 attctttgga atactactgc tagaagtctg acttaagacc cagcttatgg gccacatggc     60
 acccagctgc ttctgcagag aaggcaggcc actgatgggt acagcaaagt gtggtgctgc    120
 tggccaagcc aaagacccgt gtaggatgac tgggcctctg ccccttgtgg gtgttgccac    180
 tgtgcttgag tgcctggtga agaatgtgat gggatcacta gcatgtctgc ggagagcggc    240
 cctgggacga gattgagaaa tctgccagta atgggggatg gactagaaac ttcccaaatg    300
 tctacaacac aggcccaggc ccaaccccag ccagccaacg cagccagcac caaccccccg    360
 cccccagaga cctccaaccc taacaagccc aagaggcaga ccaaccaact gcaatacctg    420
 ctcagagtgg tgctcaagac actatggaaa caccagtttg catggccttt ccagcagcct    480
 gtggatgccg tcaagctgaa cctccctgat tactataaga tcattaaaac gcctatggat    540
 atgggaacaa taaagaagcg cttggaaaac aactattact ggaatgctca ggaatgtatc    600
 caggacttca acactatgtt tacaaattgt tacatctaca acaagcctgg agatgacata    660
 gtcttaatgg cagaagctct ggaaaagctc ttcttgcaaa aaataaatga gctacccaca    720
 gaagaaaccg agatcatgat agtccaggca aaaggaagag gacgtgggag gaaagaaaca    780
 gggacagcaa aacctggcgt ttccacggta ccaaacacaa ctcaagcatc gactcctccg    840
 cagacccaga cccctcagcc gaatcctcct cctgtgcagg ccacgcctca ccccttccct    900
 gccgtcaccc cggacctcat cgtccagacc cctgtcatga cagtggtgcc tccccagcca    960
 ctgcagacgc ccccgccagt gcccccccag ccacaacccc cacccgctcc agctccccag   1020
 cccgtacaga gccacccacc catcatcgcg gccaccccac agcctgtgaa gacaaagaag   1080
 ggagtgaaga ggaaagcaga caccaccacc cccaccacca ttgaccccat tcacgagcca   1140
 ccctcgctgc ccccggagcc caagaccacc aagctgggcc agcggcggga gagcagccgg   1200
 cctgtgaaac ctccaaagaa ggacgtgccc gactctcagc agcacccagc accagagaag   1260
 agcagcaagg tctcggagca gctcaagtgc tgcagcggca tcctcaagga gatgtttgcc   1320
 aagaagcacg ccgcctacgc ctggcccttc tacaagcctg tggacgtgga ggcactgggc   1380
 ctacacgact actgtgacat catcaagcac cccatggaca tgagcacaat caagtctaaa   1440
 ctggaggccc gtgagtaccg tgatgctcag gagtttggtg ctgacgtccg attgatgttc   1500
 tccaactgct ataagtacaa ccctcctgac catgaggtgg tggccatggc ccgcaagctc   1560
 caggatgtgt tcgaaatgcg ctttgccaag atgccggacg agcctgagga gccagtggtg   1620
 gccgtgtcct ccccggcagt gccccctccc accaaggttg tggccccgcc ctcatccagc   1680
 gacagcagca gcgatagctc ctcggacagt gacagttcga ctgatgactc tgaggaggag   1740
 cgagcccagc ggctggctga gctccaggag cagctcaaag ccgtgcacga gcagcttgca   1800
 gccctctctc agccccagca gaacaaacca aagaaaaagg agaaagacaa gaaggaaaag   1860
 aaaaaagaaa agcacaaaag gaaagaggaa gtggaagaga ataaaaaaag caaagccaag   1920
 gaacctcctc ctaaaaagac gaagaaaaat aatagcagca acagcaatgt gagcaagaag   1980
 gagccagcgc ccatgaagag caagccccct cccacgtatg agtcggagga agaggacaag   2040
 tgcaagccta tgtcctatga ggagaagcgg cagctcagct tggacatcaa caagctcccc   2100
 ggcgagaagc tgggccgcgt ggtgcacatc atccagtcac gggagccctc cctgaagaat   2160
 tccaaccccg acgagattga aatcgacttt gagaccctga agccgtccac actgcgtgag   2220
 ctggagcgct atgtcacctc ctgtttgcgg aagaaaagga aacctcaagg tctgagaaag   2280
 ttgatgtgat tgccggctcc tccaagatga agggcttctc gtcctcagag tcggagagct   2340
 ccagtgagtc cagctcctct gacagcgaag actccgaaac aggtcctgcc taatcattgg   2400
 acacggactc ttaataaaac ggtcttcagt tccagattcc ttcccagcaa gctatagctt   2460
 aagtccattt tcttccgtga aagggacagg actccatcaa gttatggaat tcctcagagc   2520
 cctgggcctg tcccccgggg tggattagtc atgtccagca gcacacgcct agtcccgcct   2580
 tcgggaaggc tgcctgcctg gccagccgcc caggtctctc tgtgtaaaga ctgcctgggc   2640
 tgtcctgccc agccttcctg gttctctggg gtcctctggg tgggtggcat ctcctggagg   2700
 gtgatgacaa tccccaacac atgcattcat gtggtgctac tctgtgtgcc aaagctaaga   2760
 ccccaagtat gttttctctc tttgtcccat ccctcttttt ctgggacttt ggaccctaac   2820
 tacttccctc ctgaaccttg cagtgacatc agtccaggag agctctcgtt cagtgtgcgg   2880
 aagaacactc tgacctctag agctgtccta gataaggagt gggagcttta gaggcaaggc   2940
 ctctagaccc tggaaggctc agtgaggctc ttcccacagc atgcttctca ctggtgccct   3000
 gtaaggctcg agccaccgct gactctgagc cttttggagt ctttcctcct tcgtctccat   3060
 tgttcccgtg catttccaaa agcttaagtt gcctggtggg catttcccca gtttctttgg   3120
 cctccgtctt ctcaagtcac atagggaaag tacctcctgg aaccaggctg cagtatgcag   3180
 gacctgccag gcaggcactg gtgaagggcc ttgggcctat catcccccca accccacctc   3240
 accccacccg cctcctctag tggggtgagt ctgggctggt ggaccagaga gggtgtcaca   3300
 gaccctcagg gactgcccca tggacacctc tgactggtgt taacagtgtg aacattttcc   3360
 ccgtcttcag tcccttagaa tgacgacagc ccctggggtt ggggcaggcg agtgtggcca   3420
 catcatccaa gccctcccag agacacaaat aggctttttt gctctaaaaa taaataccag   3480
 cccttttttg gtcacaaatc cagcatctca gcagaaaact gcctgacatg aaaagtcccc   3540
 tgaggaactg catctgcgtt tcaggggctt ttcatttttt ctcctttttt aaagtgtaga   3600
 ttgtgggtgc ttcctagagg cctgccttct tctggaactg gaagtgggct atcaccatgg   3660
 gcaagccctt gggtgcaggc tccccacctg cctgggaact ctggcagctc tcctcagctc   3720
 cttgggcttg agcagctgca actgccccag atttgctgtg gaagcagggg ctagccctgg   3780
 cctcaccagg gcctcccggg gccctgcatt gatgctcagg agttcctggg ctgctcttga   3840
 tcctttctgg gcatccagct tccagttaag ctctgtttgc caaacaaact attctcagct   3900
 gccctttggc ctgcgcctga tgtgttcctg ttgcagtccc gcctgcctga gacaggagca   3960
 ggcaggagag ccttcatgcc cagattccca caggacaatt ggggagctgc tggcattgtc   4020
 tttctgggaa gattctgctt tcttggacca aatggcagcc tgattaccca gtgtcgggcc   4080
 tgcatgctgc c                                                        4091



      <210> 1562
      <211> 440
      <212> DNA
      <213> Homo sapiens


      <400> 1562
 cccgtagacg tcttacctgc ctacgccaag cttggcacga ggggtctctg cagtgagtgg     60
 ggagcctaca taaaagagag taaagagggg caaaaaccca gatcagaatg caggcgacgt    120
 ccaaccttct caacctcctg ctgctgtctt tgtttgccgg attaaatcct tccaagactc    180
 acattaatcc taaagaaggg tggcaggtgt acagctcagc tcaggatcct gatgggcggg    240
 gcatttgcac agttgttgct ccagaacaaa acctgtgttc ccgggatgcc aaaagcaggc    300
 aacttcgcca actactggaa aaggttcaga acatgtccca gtctattgaa gtcttaaact    360
 tgagaactca gagagatttc caatatgttt taaaaatgga aacccaaatg aaagggctga    420
 aggcaaaatt tcggcagatt                                                440



      <210> 1563
      <211> 685
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(685)
      <223> n = a,t,c or g


      <400> 1563
 acgccaagct tggcacgagg gaagaacttg gcaaggatct ctttgattgt actttgtatg     60
 ttctattgaa atatgatgat tttaatgctg acaagcacct ggctcttgaa gaattttata    120
 gagcattcca agtgatccag ttgagtctgc cagaagatca gaaactaagc atcactgcag    180
 caactgtggg acaaagtgct gttctgagct gtgccattca aggaaccctg agacctccca    240
 ttatctggaa aaggaacaat attattctaa ataatttaga tttggaagac atcaatgact    300
 ttggagatga tgggtccttg tatattacta aggttaccac aactcacgtt ggcaattaca    360
 cctgctatgc agatggctat gaacaagtct atcagactca catcttccaa gtgaatgttc    420
 ctccagtcat ccgggtgtat ccagagagtc aggctaggag agccgggggt aactgccagt    480
 cttagggtgc catgcaggag gggcatacca aagccttcag cttgggctgg gtttgaagga    540
 tgggaattgg atatttacac ccaaagcttt tcccaaacaa cttcacggtt ttcaaggcaa    600
 tggggcagtt gagggtttca cattaaggca ttgttncgct atggaggtta cngggggctt    660
 acanttgttt tcgcaaggat tgagt                                          685



      <210> 1564
      <211> 418
      <212> DNA
      <213> Homo sapiens


      <400> 1564
 cgacccacgc gtccgtactt gtgcaactcc tttactgggc cttctaatat aaatcgtgtt     60
 ttgttgaact gtctgtaaat gttttatcaa atgatttgga ccaatggacc agccaagctt    120
 ccagccagtt caacaaaaca cgatttatac ttgtgcaact cctttacagg gccttctaat    180
 ataatttgga atttggggag cagatacata ttcactgtta tcaagcatgg tttgggtttt    240
 tttttaaaca caattttagc tgtgttaaac attgctggca ggaatctaaa gtgctacaaa    300
 ttctgtgaag gacaatggca acaccaaaca aaattacaca tgtgtttgcc ccatgaaagc    360
 aatccatctt ctaagaattt accctaaagt tgtgttttag tccgttcttg cacttagg      418



      <210> 1565
      <211> 447
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(447)
      <223> n = a,t,c or g


      <400> 1565
 gtaatagaga aanattctag acctgagagc tcgaanncgg annnnggnnn gaannnctat     60
 tactgttgac agaaacacgg aaaccagaac ttcctcattt agcatcattt ctgtccctgc    120
 ttccagcacc tgagggtctc cgagccgtgt gatttatgcc aagcttggtg gtgagatcct    180
 ggactacagg gacttggcag cccttcctaa aagtaaggcc atctatgaca tcgaccgccc    240
 cgacatgatc tcctactcac cctacatcag ccactctgca ggggacaggc agagctacgg    300
 cgagtcccct cagttgctct cgccaacgcc gaccgagggg gatcaggatg accggtccta    360
 caagcagtgt cggacctcca gcccaagctc cactgggttg gttagcctcg ggcgctacac    420
 tccgacctca cgggcaccac agcactc                                        447



      <210> 1566
      <211> 834
      <212> DNA
      <213> Homo sapiens


      <400> 1566
 tcgacccacg cgtccgattt actgtgtgtg ggaccccaac ttacgtagct cccgaaattc     60
 tttctgagaa aggttatgga ctggaggtgg acatgtgggc tgctggcgtg atcctctata    120
 tcctgctgtg tggctttccc ccattccgca gccctgagag ggaccaggac gagctcttta    180
 acatcatcca gctgggccac tttgagttcc tcccccctta ctgggacaat atctctgatg    240
 ctgctaaaga tctggtgagc cggttgctgg tggtagaccc caaaaagcgc tacacagctc    300
 atcaggttct tcagcacccc tggatcgaaa cagctggcaa gaccaataca gtgaaacgac    360
 agaagcaggt gtcccccagc agcgagggtc acttccggag ccagcacaag agggttgtgg    420
 agcaggtatc atagtcacca ccttgggaat ctgtccagcc cccagttctg ctcaaggaca    480
 gagaaaagga tagaagtttg agagaaaaac aatgaaagag gcttctttca cataattggt    540
 gaatcagagg gagagacact gagtatattt taaagcatat taaaaaaatt aagtcaatgt    600
 taaatgtcac aacatatttt tagatttgta tatttaaagc ctttaataca tttttggggg    660
 gtaagcattg tcatcagtga ggaattttgg taataatgat gtgttttgct tcccctttgt    720
 aaccaagttt attctgtact acaggagtgg tgcttaccag ggtctaaact ccccctgtga    780
 gattaataag gtgcattgtg gtctttctgt gttaataaaa tgtgctctga ataa          834



      <210> 1567
      <211> 834
      <212> DNA
      <213> Homo sapiens


      <400> 1567
 tcgacccacg cgtccgattt actgtgtgtg ggaccccaac ttacgtagct cccgaaattc     60
 tttctgagaa aggttatgga ctggaggtgg acatgtgggc tgctggcgtg atcctctata    120
 tcctgctgtg tggctttccc ccattccgca gccctgagag ggaccaggac gagctcttta    180
 acatcatcca gctgggccac tttgagttcc tcccccctta ctgggacaat atctctgatg    240
 ctgctaaaga tctggtgagc cggttgctgg tggtagaccc caaaaagcgc tacacagctc    300
 atcaggttct tcagcacccc tggatcgaaa cagctggcaa gaccaataca gtgaaacgac    360
 agaagcaggt gtcccccagc agcgagggtc acttccggag ccagcacaag agggttgtgg    420
 agcaggtatc atagtcacca ccttgggaat ctgtccagcc cccagttctg ctcaaggaca    480
 gagaaaagga tagaagtttg agagaaaaac aatgaaagag gcttctttca cataattggt    540
 gaatcagagg gagagacact gagtatattt taaagcatat taaaaaaatt aagtcaatgt    600
 taaatgtcac aacatatttt tagatttgta tatttaaagc ctttaataca tttttggggg    660
 gtaagcattg tcatcagtga ggaattttgg taataatgat gtgttttgct tcccctttgt    720
 aaccaagttt attctgtact acaggagtgg tgcttaccag ggtctaaact ccccctgtga    780
 gattaataag gtgcattgtg gtctttctgt gttaataaaa tgtgctctga ataa          834



      <210> 1568
      <211> 1333
      <212> DNA
      <213> Homo sapiens


      <400> 1568
 tttttttttt ttccatgaga tgcctgccat gacaggcgcc acaaaccttt cctttaattg     60
 caaaacatgt cccagtcccg ggaggcttgg gaagagtggg aaccagggga acccagggat    120
 gggattccac tgaaaacaaa ccgtcctgct gtcctgtcga gggcccccac ccacaggatg    180
 tagccatggg acagccactg agggtccagg aagaggggcg gcagagcagg gaggcaggga    240
 cagggagggg tcgccccagg gcagtggcag ggctggaact cgtccctaac atccctgagc    300
 cccagcaggt gccctgtgtt agaagcgaga gggctggtgg gggtgcgtgg acaaggggca    360
 gaatgatcct gcccccaacc agtatcgcca ggcgctggcc cagtggcccc aggccctggc    420
 agctggcgtc ttccgctgcc ttccctctgc tctgcgcggg gacattcagt gcgctgggga    480
 ggcctcggtg atggccctct ccacccgcag gtaccagggc tggatgtgcg tgtgctgcat    540
 caggtcatcg aatgcatcca gcccctccat cacacgcagc acgccataca ccgccaaatc    600
 agcgagattc ggcttctggc cccccatgaa gggccggtcc ttgcccacag cagccaccca    660
 cttgtcagca gcctcataga ggtcctcgcg cacgttgtcc tggaggcggt gcctgctctt    720
 gagtcgcttg ctgatgaggt acatggccgc tgcacccatg tacttggcca cggcaccctc    780
 cacggctccg aacttgccct cgcggacaat gtagtcaaag gacgccagag cctcggtggg    840
 cgtgcggtac acattggggg agatcaggtg caccagccag tcgtccgccc actgccgcca    900
 cttcatctcc tccgtcctgg cctccttccc accatacact tgctgggcct ccttctcgtt    960
 gagcatgagc cagtacttat tgccgaactc ggtcacctcc ttgccctgct cgttcacagc   1020
 cttcatggct gggtagtagg tgatgatctc ttccaggggc tgccccgaca ccaggtaggt   1080
 cttgagggcg ctgatgatga cagaggagtc atttagttgt tgcgagcttt ctccttcctg   1140
 ggccaccagg atgggcacct ttctgtagga ggagaacttg atctcagccc tgcgctcagg   1200
 gttcacctcc accacctggt agggcagggc atggaagtcg aggaaggctc ggaccccgct   1260
 gcagaaggga cacgtcgtgt actggtacag ggtcagctgc aggcggctgc acagggagag   1320
 ctgagcggct gag                                                      1333



      <210> 1569
      <211> 1029
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1029)
      <223> n = a,t,c or g


      <400> 1569
 tttttttttt ttagcagaca cagacacaga tgtttattcc aggaagaggt ctaagaaacg     60
 agcttcttag agcatgtgtc acggggcagc cagtcctggg gctctcagag ccagccccct    120
 cccttcagca gctgaagcaa tagcgccccc attttacagg cggagcatgg aagccagaga    180
 ggtgggtggg ggagggggtc cttccctggc tcaggcagat gggaagatga ggaagccgct    240
 gaagacgctg tcggcctcag agccctggta aatgtgaccc tttttggggt ctttttcaac    300
 ccagacctgg tcaccctgct gcagctgaag caccatgccc cctgacacca cctggaagag    360
 ccccttgttg gtggtgtcac agaagcccag ggagcgtcgg acctggcccc ttgaggagga    420
 gacgatggac aggcagattt cccactggga cagcacctgg aaggtgaagt agtagtagcc    480
 gggtacagtg cagacgaatc ggccggagtg gttctggtac ggttcttcct ggttggtgat    540
 gaccgtgtcg aagatgacca cgttgccccc cattgggggg ttccgccgaa tggcggagaa    600
 ggctggcctc ggctggtcct tgatgtttcc tgggctgccc ttggtgcctt taattcccgg    660
 gatgccacgg gccccgaggg ggccgctggg ccctgggtag cccaccttgc cggggtttcc    720
 agagggccca ggttccccct ggtctccttt aaggccttgg atgcctgtcc ggatgccagg    780
 ggcccccggc tccccttgct cccccttgag gcctggccgc ccccgtctgc caggtcttcc    840
 tgcctcccct ttcttcccgt ctggtgctcg gcacaagtcc tcggtcacca tagaggccag    900
 cgatatggcc agcacacaga gcaccagcca tccccgggga ccctccatga tgcctctgcc    960
 tcctgttgtc gactgccgct gcatgcgaat tcgacctcac aggactaggg gtctcgaant   1020
 tttttttct                                                           1029



      <210> 1570
      <211> 420
      <212> DNA
      <213> Homo sapiens


      <400> 1570
 cgctccgcag gtttagcacc gactgtagct ctgatcagca ggaccgatta aacggaactg     60
 cccctagcgg ttttaaccgc tcctgaccag tcccgttgcc gcaccccatc ttggaagtat    120
 gccctggcca gtaggagcca caaagcgcga ttagcctcac tgcatttcag gtacaggccg    180
 gcgccagccg tgcctcacca ggtccaccgg ctccgagcag cagcaagccc ggtcggaaag    240
 cgaaagtggc ctcgccatgt ccagaccggc cagctccccc gcctacctga ccccgccccg    300
 cagccgcacc tgggtccgag tcatcgccgc ggccgccacg gccccgcaca ggaaggcggc    360
 agcaaagagc gcacgctcga cgcgctgcag ccaggacagc gccatggcgc ccctcgtgcc    420



      <210> 1571
      <211> 2744
      <212> DNA
      <213> Homo sapiens


      <400> 1571
 tttttttttt ttaagttcaa aagtacattt atttaaaatg tgggcaagat atcaatataa     60
 aagaaaacag agtataagaa ataaaaataa tcaaagtaca aaacatttca aatctttaac    120
 atccataatt tagagatagc aaggtcttta tttacaccat tttatttcta gtttgaagtc    180
 ccgtaacagt tttgtgaaaa catttaaaaa cctgggcaaa tgaatcataa aacctaatgt    240
 ggggctctta aagtcatata atacaaaaca taatttatgt ttccctcagg attaaaattg    300
 caccatcttt aaaagggtgc cggtatattt attatatcct gtccttcccc gcttcacagt    360
 ctggatcccc caggaaaggc agctgggaaa accagagcct gtgaagggaa gcgcagcagc    420
 ttcctcgcca gaccagaaca gccagccccg caccgcagga agtccgacat gcacggcagc    480
 ctagacgccc atagttaaac cttatatgat tcatagtcca gcgtttgagt gagcacttca    540
 gtcagaacga aactctgcat tgtgaacatc tatgccctct ggcaaaatat tcttcggata    600
 aaatgaaggt cattttccac aggataatta aaattatttc ccgaacaaac tcgaagttcc    660
 tgcttgtgct cccatgagct tccggaaaga tggctgcctt ggataacacc tttcctcctg    720
 cacactctac gattgccttc atagtggaaa gacttgggca gattcccagg tgtgatgtaa    780
 aaatattttg ccttaaagag tggagaaacg tgtgcccgtt ttaaggattc ttccaagctg    840
 aaagagaaaa gtacttctgc ctcagcatct cggagaatgt agttctgctc atcaatgaac    900
 ttctgacacc tgaagcattc ttccagccac tctggcgtca ctatgtgctt cacgacagaa    960
 atcgcccgcc aggaacttca cggtgcgagt cactttgctg gcaataaggt gtgtgcactt   1020
 ctgtgcagac tccgcaacct ctccaccaag aatgtagagc ttcttaaata tactgttgaa   1080
 cctggacagg ctcgaatcca gtgaaaagca caaaaagggg tcaattcttg gagttagctt   1140
 tttagtggga ggtggtacgg tcttcaattc tggctctttt ggaagaaagg ctggacatta   1200
 gctacttcat tctgtttcag tttgggaggt agtcttatac tcatcaacaa ctctgcagac   1260
 acttttaagg gaactctcca agcatctaaa agatttaaaa ctaaatgctg ggtaggggca   1320
 aatggatcct gcagactgaa tgccgtgtag cgactatact gaatctgcct cagtgcctca   1380
 aagtttccca gaagaatgtc gccaagccac tgggcgttga cacagggtat cctccactct   1440
 ttggcttttt catactttaa accagttggt tctttacaga tgaggactgt gttgctgcgg   1500
 catagataac ccgtatattt ggcacctgcc aaataagcca ttaattttag gtcatctctg   1560
 tcactatcaa caaatccagt cacagaaata atatgctgtg aacatggctt tcctcctggt   1620
 gggaaggcca ctgggaagtg aagggctcgg tgcggcggta ccattttctt cttctttaag   1680
 actgtgttta accagtgtgc agtaacacat ctctttcttt ctcttattgc ctgtgcatac   1740
 gcgctgctga cttgactctc acagagaagg tgcgtgcatc gactcgtgaa ggtggggtca   1800
 acagtgccgc catgtgcctg gattatcctt ttccaggtgg ccagcagttg cttatcagac   1860
 atctgctctg gataatccgc aattgcaaac acacatccca ataagaagcc ttcttctgga   1920
 atctccactg ctggatcatg tccaaaaagc tgatgctgct gaggcgatgg tggtggctgc   1980
 tgttgctgct gctgctgctg tgaaaatgga tgcggcggct gctgggggta aggttgctga   2040
 gagatctgct gctgctgctg ctgctggagc tgcattatct gctggggctg aaggtgtaaa   2100
 accgggtgct gctgctgctg ctgctgggcc tgctgctgct gctgtagcat gtgtgtctct   2160
 ggagtcactt tcacttggct aaacagcact gcattggcat ttgtatgtcc ctgctggctg   2220
 tgattcacct gctgttctaa atttttcgta ggtgctgaaa gagtctgtaa gatatgtgct   2280
 acatttgatg gccggttcat ctgctgaatg tcagcattat tagtaatatt cctcagtgtc   2340
 cgtacagctg gactccaggt agctatcatt tctgatcttt cagaactttg gaggttttgt   2400
 ccagcagcca ttaaattacc ccggacctca gggggcaaaa tgttacctgg gacgggtggg   2460
 acattggcac acaagttaat caacccaggc tcctttccct gaggcagcct gcgttttgct   2520
 gcagctaact gtgggacttc ggccggggtc cagtttaaat ttctctcctg tttttccggt   2580
 gatgaatctg aagaatcatc aaacattaat tcccctttag atttttcagt gttggattta   2640
 ggagaaaact gctggtcacc tgaaggagac ccttcttgag agctggcagg gcttgacttc   2700
 tcatctgtac taccctcatt ctgagaatct tgttcctcat tttc                    2744



      <210> 1572
      <211> 2744
      <212> DNA
      <213> Homo sapiens


      <400> 1572
 tttttttttt ttaagttcaa aagtacattt atttaaaatg tgggcaagat atcaatataa     60
 aagaaaacag agtataagaa ataaaaataa tcaaagtaca aaacatttca aatctttaac    120
 atccataatt tagagatagc aaggtcttta tttacaccat tttatttcta gtttgaagtc    180
 ccgtaacagt tttgtgaaaa catttaaaaa cctgggcaaa tgaatcataa aacctaatgt    240
 ggggctctta aagtcatata atacaaaaca taatttatgt ttccctcagg attaaaattg    300
 caccatcttt aaaagggtgc cggtatattt attatatcct gtccttcccc gcttcacagt    360
 ctggatcccc caggaaaggc agctgggaaa accagagcct gtgaagggaa gcgcagcagc    420
 ttcctcgcca gaccagaaca gccagccccg caccgcagga agtccgacat gcacggcagc    480
 ctagacgccc atagttaaac cttatatgat tcatagtcca gcgtttgagt gagcacttca    540
 gtcagaacga aactctgcat tgtgaacatc tatgccctct ggcaaaatat tcttcggata    600
 aaatgaaggt cattttccac aggataatta aaattatttc ccgaacaaac tcgaagttcc    660
 tgcttgtgct cccatgagct tccggaaaga tggctgcctt ggataacacc tttcctcctg    720
 cacactctac gattgccttc atagtggaaa gacttgggca gattcccagg tgtgatgtaa    780
 aaatattttg ccttaaagag tggagaaacg tgtgcccgtt ttaaggattc ttccaagctg    840
 aaagagaaaa gtacttctgc ctcagcatct cggagaatgt agttctgctc atcaatgaac    900
 ttctgacacc tgaagcattc ttccagccac tctggcgtca ctatgtgctt cacgacagaa    960
 atcgcccgcc aggaacttca cggtgcgagt cactttgctg gcaataaggt gtgtgcactt   1020
 ctgtgcagac tccgcaacct ctccaccaag aatgtagagc ttcttaaata tactgttgaa   1080
 cctggacagg ctcgaatcca gtgaaaagca caaaaagggg tcaattcttg gagttagctt   1140
 tttagtggga ggtggtacgg tcttcaattc tggctctttt ggaagaaagg ctggacatta   1200
 gctacttcat tctgtttcag tttgggaggt agtcttatac tcatcaacaa ctctgcagac   1260
 acttttaagg gaactctcca agcatctaaa agatttaaaa ctaaatgctg ggtaggggca   1320
 aatggatcct gcagactgaa tgccgtgtag cgactatact gaatctgcct cagtgcctca   1380
 aagtttccca gaagaatgtc gccaagccac tgggcgttga cacagggtat cctccactct   1440
 ttggcttttt catactttaa accagttggt tctttacaga tgaggactgt gttgctgcgg   1500
 catagataac ccgtatattt ggcacctgcc aaataagcca ttaattttag gtcatctctg   1560
 tcactatcaa caaatccagt cacagaaata atatgctgtg aacatggctt tcctcctggt   1620
 gggaaggcca ctgggaagtg aagggctcgg tgcggcggta ccattttctt cttctttaag   1680
 actgtgttta accagtgtgc agtaacacat ctctttcttt ctcttattgc ctgtgcatac   1740
 gcgctgctga cttgactctc acagagaagg tgcgtgcatc gactcgtgaa ggtggggtca   1800
 acagtgccgc catgtgcctg gattatcctt ttccaggtgg ccagcagttg cttatcagac   1860
 atctgctctg gataatccgc aattgcaaac acacatccca ataagaagcc ttcttctgga   1920
 atctccactg ctggatcatg tccaaaaagc tgatgctgct gaggcgatgg tggtggctgc   1980
 tgttgctgct gctgctgctg tgaaaatgga tgcggcggct gctgggggta aggttgctga   2040
 gagatctgct gctgctgctg ctgctggagc tgcattatct gctggggctg aaggtgtaaa   2100
 accgggtgct gctgctgctg ctgctgggcc tgctgctgct gctgtagcat gtgtgtctct   2160
 ggagtcactt tcacttggct aaacagcact gcattggcat ttgtatgtcc ctgctggctg   2220
 tgattcacct gctgttctaa atttttcgta ggtgctgaaa gagtctgtaa gatatgtgct   2280
 acatttgatg gccggttcat ctgctgaatg tcagcattat tagtaatatt cctcagtgtc   2340
 cgtacagctg gactccaggt agctatcatt tctgatcttt cagaactttg gaggttttgt   2400
 ccagcagcca ttaaattacc ccggacctca gggggcaaaa tgttacctgg gacgggtggg   2460
 acattggcac acaagttaat caacccaggc tcctttccct gaggcagcct gcgttttgct   2520
 gcagctaact gtgggacttc ggccggggtc cagtttaaat ttctctcctg tttttccggt   2580
 gatgaatctg aagaatcatc aaacattaat tcccctttag atttttcagt gttggattta   2640
 ggagaaaact gctggtcacc tgaaggagac ccttcttgag agctggcagg gcttgacttc   2700
 tcatctgtac taccctcatt ctgagaatct tgttcctcat tttc                    2744



      <210> 1573
      <211> 1653
      <212> DNA
      <213> Homo sapiens


      <400> 1573
 gcggccgccg cctccgctct gagccccgcc ccgctcggcc gccgattgct cgggcctggc     60
 cgccagcgcc aggggccgat ggccgagcgc gtcgcactcg cgtccctgcg ccgtgcctgc    120
 ctcgcgctcc ctgttacggc gttcgtcccc gggcctggcg cccgcgtccg gcccggctcc    180
 gcggcggcct ggtccgatgg ctcctcagcg gagggccgca accaaggcgc ccgagggcaa    240
 cggagcggcc gagcgccgga accggagcag caccaagaag gaccgagccc cgcgggaggt    300
 gcagaggctg tggcagaggc cgtggctaag gaccgcgggc ctgggggctg gctttgtgct    360
 caccgcactc ctgctctgga gcagcttggg ggccgacgac ggggtcgcag aggtcctggc    420
 ccgccgtggc gaggtcgtgg cagggagatt catcgaggtg ccctgctctg aggactacga    480
 cagtcaccgc aggttcgaag gctgcactcc ccgaaagtgc ggcagaggtg tcaccgatgt    540
 cgtcatcacc agggaggaag cggagcggat tcgcagcgta gctgaaaagg ggctctccct    600
 gggaggatct gacggagggg catccattct ggacttgcac tcaggggccc tgtctgtcgg    660
 gaagcacttt gtgaacctgt acagatactt cggggataaa atacagaaca tcttctcaga    720
 ggaggacttc cggttatacc gggaggtgcg gcagaaggtc cagctcacca ttgctgaggc    780
 ttttggcatc agcgcatcct cgctgcatct gaccaagccc accttcttct cccgcataaa    840
 cagcacggaa gcgcggacgg cgcacgacga gtactggcat gcgcacgtgg acaaggtgac    900
 ctacggctcc ttcgactaca cctcgctgct gtacctctcc aactacctgg aggacttcgg    960
 cggagggcgg ttcatgttca tggaggaggg tgccaacaag acggtggagc cgagagctgg   1020
 atgtttttgt ttccggatga tgtcttgtgg gttccaagaa gttaatggac cgagagccag   1080
 tgaagctgct ggtgcgaagg ctggagtcag gtgtcctccg gggactcacc acccgtccga   1140
 gaggggagag acacatgcga ttctggaagc tgagagcatt gcttattgtt gattccttgg   1200
 ttgccgtgct gagtcctgct ttaaggaagc aggtcgcgtc tccttcttca cctcggggtc   1260
 cgagaaccta caccgcgtgg agaaggtcca ctggggcacc cgttacgcca ttaccatcgc   1320
 cttcagctgc aaccccgacc atggcatcga ggacccagcg ttcccgtagc cagcagccgg   1380
 gccaaggtaa cttcaggagg gcccgtgtgg aggcagccgc gccagtcgtg cacccacccc   1440
 cacgtccacc cgctcctgtt gcacagagtg ccttaggaat tctctgattt tgatttgctg   1500
 acgtgttaat cttttcatct gtgagtaaat gaagggaacc agcttttcac ttctccagca   1560
 tcatgtgtgc ttgggctgta ggcctgggag cctgaggtgg aggccaggaa agggacccag   1620
 caggacgggg cacaagtccc catctgtgaa tgg                                1653



      <210> 1574
      <211> 1146
      <212> DNA
      <213> Homo sapiens


      <400> 1574
 taaaaagaaa acctttactg aatcagctga gtgttaataa tacgaatttc cttttcttgc     60
 caattctgat ctgaacagaa aatccaagaa cagggatatg tgtggattac agttttctct    120
 gccttgccta cgactgtttc tgccttgcat ccaagggtcc ttaagccgtt gtcttcattg    180
 attcatcttc aggcaaattc taatccttgg gaatgtaact gcaaactttt gggccttcga    240
 gactggctag catcttcagc cattactcta aacatctatt ggcagaatcc cccatccatg    300
 cgtggcagag cattacgtta tattaacatt acaaattgtg ttacatcttc aataaatgta    360
 tccagagctt gggctgttgt aaaatctcct catattcatc acaagactac tgcgctaatg    420
 atggcctggc ataaagtaac cacaaatggc agtcctctgg aaaatactga gactgagaac    480
 attactttct gggaacgaat tcctacttca cctgctggta gattttttca agagaatgcc    540
 tttggtaatc cattagagac tacagcagtg ttacctgtgc aaatacaact tactacttct    600
 gttaccttga acttggaaaa aaacagtgct ctaccgaatg atgctgcttc aatgtcaggg    660
 aaaacatctc taatttgtac acaagaagtt gagaagttga atgaggcttt tgacattttg    720
 ctagcttttt tcatcttagc ttgtgtttta atcatttttt tgatctacaa agttgttcag    780
 tttaaacaaa aactaaaggc atcagaaaac tcaagggaaa atagacttga atactacagc    840
 ttttatcagt cagcaaggta taatgtaact gcctcaattt gtaacacttc cccaaattct    900
 ctagaaagtc ctggcttgga gcagattcga cttcataaac aaattgttcc tgaaaatgag    960
 gcacaggtca ttctttttga acattctgct ttataactca actaaatatt gtctataaga   1020
 aacttcagtg ccatggacat gatttaaact gaaacctcct tatataatta tatactttag   1080
 ttggaaatat aatgaattat atgaggttag cattattaaa atatgttttt aataataaaa   1140
 aaaaaa                                                              1146



      <210> 1575
      <211> 958
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(958)
      <223> n = a,t,c or g


      <400> 1575
 ggctgtccga ctcaacatat cctatcctcc tcagaacttg accatgactg tcttccaagg     60
 agatggcaca gcatccacaa ccttgaggaa tggctcggcc ctttcagtcc tggagggcca    120
 gtccctgcac cttgtctgtg ctgtcgacag caatccccct gccaggctga gctggacctg    180
 ggggagcctg accctgagcc cctcacagtc ctcgaacctt ggggtgctgg agctgcctcg    240
 agtgcatgtg aaggatgaag gggaattcac ctgccgagct cagaaccctc taggctccca    300
 gcacatttcc ctgagcctct ccctgcaaaa cgagtacaca ggcaaaatga ggcctatatc    360
 aggagtgatg ctaggggcat tcgggggagc tggagccaca gccctggtct tcctgtcctt    420
 ctgcatcatc ttcgttgtag tgaggtcctg caggaagaaa tcggcaaggc cagcagtggg    480
 cgtgggggat acaggcatgg aggacgcaaa cgctgtcagg ggctcagcct ctcagggacc    540
 cctgattgaa tccccggcag atgacagccc cccacaccat gctccgccag ccctggccac    600
 cccctcccca gaggaaggag agatccagta tgcatccctc agcttccaca aagcgaggcc    660
 tcagtaccca caggaacagg aggccatcgg ctatgagtac tccgagatca acatccccaa    720
 gtgagaaact gcagagactc aggcctgttt gagggctcac gacccctgca gcaaagaagc    780
 ccgagactga ttcctttaga attaacagcc ctccatgctn nnnnnnnnnn nnnnnnnnnn    840
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ttctccatcc    900
 aatcggtcca cactccccgc ccccggcctc tggtacccac cattctcttc tctactta      958



      <210> 1576
      <211> 2222
      <212> DNA
      <213> Homo sapiens


      <400> 1576
 ccatagtatc agttcaagct aagaaagcct taagaattca ataactcaaa atctctttga     60
 gatttaaagt taaaaagtaa tatgtttcta ataatttcta atgtgcagga ttaatgacaa    120
 ctgtattttg cattggcaaa ttatctcagc cagaagagat tcaaatgatt ttcgtcaatg    180
 ccagtttata aactagcagc acatgtcaat gccaagcttg tgaatggatt ggctgagaaa    240
 aattatatga gttagaaggg atctaagtgc tatactggtc actgattcta tttcacaaaa    300
 gctaccattt ttaaaagctg aaaatgtaat tggtgttgac aaaaacatgt taagttcaat    360
 tactctgtat agctaaatat agaaaattgg ttaatgttta aagcaacttc ttatttgtta    420
 agaagataat taaaaatagt taaaactgaa caattagcta tacttttata ttattaaaat    480
 ccaatgaatt taacaaatga aacccacagg aaaagagatg atataattca aggcatagat    540
 ttgacatgtc agaatacggc aaaaacaata aagatagcat cagtaaaaca gttgtaaaat    600
 aagtaaacaa ttttcaagtg tgcaaaacta gtcaggaata aaagtgctat gtgtggatac    660
 ctgggttttc aaatatttgt ttcaaaaact ttcagctgga tgggtggaaa aactagaaag    720
 tattatataa gtaaaaattt taaagaatta tataaaaccc tactttatta tcttacatta    780
 tgtccttgtt atgtcacttg ctgaatctga ggcctattta attaccagat acaacacaaa    840
 aggaggtaaa cacagtacat cacaaaggct gatttatcct gaaccgtaaa aaggctcctt    900
 ttcaaggtat acctgtggat ttgtgtttca tcttatatcc tcaggcacct ctaggctgtt    960
 gatgaatttg aaaaccggac aaccatgatt ttctataatt tctaatatac atatttagta   1020
 catcttgcag aactgccctt taggtaggtc aatatttggg aagcaattgt tacaggaaat   1080
 aaaaacaatt taaattcatg aaagtaaacc ccatcactgc cacaatttaa ataatcattt   1140
 taatgtgtaa atcctgaata tatcatgtta gaagatgaag tcgatgtatt tagcataatc   1200
 tgtcttggga tatttgacgt gtagatgact aaaaatacac ttgtggtcgt ttcttcactt   1260
 tgtattttag cgacccgtac cgcacctctt tgcggccttt ggtggttttc acagatttca   1320
 tgctttgcga tcttcgaggc cctttgtgtg ttaacatctc attatctgaa tatggcccct   1380
 ctgcttcttc atctgttttc tcatctccgt ctttcagtgg aattccataa cctgctgatt   1440
 cactgggggc tggtttactt ttcttttttg cttctggtag aggttggtat ggtctttgtc   1500
 ccacaggctc atcaccttgg atagttgtta aatcatgcat actgaagctt cttaaacgtt   1560
 cagttattgc tccttggctc tttactgctg cagtaacagc agcagtagct gcaaggttta   1620
 aaccttgccg tccaaagttt accatggttt catagcctcg ttcctttgct tgtacaatat   1680
 aatcatcaat ctccctttcc tttgaagaaa gaagtggatg aaggaatttt ctatatatta   1740
 aacttgctcc tttggtatag ggagaaagca gccatatgac aaaagcaatc ttcagctcat   1800
 agtacagggg aaaccaagca actgtttgat cggctactgt ttcaatcaca gtatagagag   1860
 caaaaacaat ccagtacatc atccatcgaa catattcctt cacgtttttt gttttcacag   1920
 ctttgtatga ataatatgca ggataaagca ttccaaacac cagcaccacg gctctggaga   1980
 tcatccagga caccatcttc acgggggctt gggccccacg tccgtggtgc tggatgtggc   2040
 tctatcgtcc acacggagga aggagggtgg gagggtggtg cagaacccac ccgccccagg   2100
 tgagaagccc aaaagccata ggtggccacc tacgatgaca ccagaaaaca aatgaggctg   2160
 cttcttcttg gatgcccagc tccaggcttc tgtgaggagg agagactgtt cgggtgacga   2220
 aa                                                                  2222



      <210> 1577
      <211> 910
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(910)
      <223> n = a,t,c or g


      <400> 1577
 cgaggctaca accccaacgt gaatgcaggc atcattaact cttttgctac tgcagccttt     60
 agatttggcc acacattaat caatcctatt ctttaccgac tgaatgccac cttaggtgaa    120
 atttccgaag gccaccttcc gttccataaa gcgctctttt caccgtccag aataatcaag    180
 gaaggtggga tagacccggt tctccggggg ctgtttggcg tggctgctaa atggcgggca    240
 ccctcctacc ttctcagtcc tgagctgacc cagaggctct tctccgcggc ttattctgcg    300
 gccgtggatt cggctgccac catcattcaa aggggtagag accacgggat cccaccatat    360
 gttgacttca gagttttctg taatttgact tcagttaaga actttgagga tcttcaaaat    420
 gaaattaaag attcagagat tagacaaaaa ctgagaaagt tgtacggctc tccaggtgac    480
 attgacctct ggcccgccct tatggttgaa gacctgattc ctggtacaag agtgggacca    540
 acacttatgt gcatttgtta cccagtttca gcggctaaga gatggagata ggttctggta    600
 tgaaaaccct ggagtattta ccccggcaca actcactcag ctgaagcagg cgtccctgag    660
 ccgggtgctt tgtgacaatg gtgacagcat tcagcaagtg caggctgatg tctttgtaaa    720
 nggcaagaat acccacagga ttacctgaac tgcaagcgag aatccccgaa tgtggaccct    780
 gcgaagtgtn gcaaagactt nctggtgaga actggtaagg agtangagga cagttccaga    840
 gcagtngacg caagaagtct caaaagaaac gctcagcttc aatacagcta tcctgtttga    900
 taaggatatt                                                           910



      <210> 1578
      <211> 910
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(910)
      <223> n = a,t,c or g


      <400> 1578
 cgaggctaca accccaacgt gaatgcaggc atcattaact cttttgctac tgcagccttt     60
 agatttggcc acacattaat caatcctatt ctttaccgac tgaatgccac cttaggtgaa    120
 atttccgaag gccaccttcc gttccataaa gcgctctttt caccgtccag aataatcaag    180
 gaaggtggga tagacccggt tctccggggg ctgtttggcg tggctgctaa atggcgggca    240
 ccctcctacc ttctcagtcc tgagctgacc cagaggctct tctccgcggc ttattctgcg    300
 gccgtggatt cggctgccac catcattcaa aggggtagag accacgggat cccaccatat    360
 gttgacttca gagttttctg taatttgact tcagttaaga actttgagga tcttcaaaat    420
 gaaattaaag attcagagat tagacaaaaa ctgagaaagt tgtacggctc tccaggtgac    480
 attgacctct ggcccgccct tatggttgaa gacctgattc ctggtacaag agtgggacca    540
 acacttatgt gcatttgtta cccagtttca gcggctaaga gatggagata ggttctggta    600
 tgaaaaccct ggagtattta ccccggcaca actcactcag ctgaagcagg cgtccctgag    660
 ccgggtgctt tgtgacaatg gtgacagcat tcagcaagtg caggctgatg tctttgtaaa    720
 nggcaagaat acccacagga ttacctgaac tgcaagcgag aatccccgaa tgtggaccct    780
 gcgaagtgtn gcaaagactt nctggtgaga actggtaagg agtangagga cagttccaga    840
 gcagtngacg caagaagtct caaaagaaac gctcagcttc aatacagcta tcctgtttga    900
 taaggatatt                                                           910



      <210> 1579
      <211> 910
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(910)
      <223> n = a,t,c or g


      <400> 1579
 cgaggctaca accccaacgt gaatgcaggc atcattaact cttttgctac tgcagccttt     60
 agatttggcc acacattaat caatcctatt ctttaccgac tgaatgccac cttaggtgaa    120
 atttccgaag gccaccttcc gttccataaa gcgctctttt caccgtccag aataatcaag    180
 gaaggtggga tagacccggt tctccggggg ctgtttggcg tggctgctaa atggcgggca    240
 ccctcctacc ttctcagtcc tgagctgacc cagaggctct tctccgcggc ttattctgcg    300
 gccgtggatt cggctgccac catcattcaa aggggtagag accacgggat cccaccatat    360
 gttgacttca gagttttctg taatttgact tcagttaaga actttgagga tcttcaaaat    420
 gaaattaaag attcagagat tagacaaaaa ctgagaaagt tgtacggctc tccaggtgac    480
 attgacctct ggcccgccct tatggttgaa gacctgattc ctggtacaag agtgggacca    540
 acacttatgt gcatttgtta cccagtttca gcggctaaga gatggagata ggttctggta    600
 tgaaaaccct ggagtattta ccccggcaca actcactcag ctgaagcagg cgtccctgag    660
 ccgggtgctt tgtgacaatg gtgacagcat tcagcaagtg caggctgatg tctttgtaaa    720
 nggcaagaat acccacagga ttacctgaac tgcaagcgag aatccccgaa tgtggaccct    780
 gcgaagtgtn gcaaagactt nctggtgaga actggtaagg agtangagga cagttccaga    840
 gcagtngacg caagaagtct caaaagaaac gctcagcttc aatacagcta tcctgtttga    900
 taaggatatt                                                           910



      <210> 1580
      <211> 536
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(536)
      <223> n = a,t,c or g


      <400> 1580
 aaagtacatc acatggatgt ggtacattta atttaaccag gtacctgtta atggtcacct     60
 aggttatttt gtcatctttt tccccctata atgtggcatt gaacatttta gtaccttaat    120
 ctctgtgtgt ttttaattct ttacctagga taaatgtctc tatgtgatat taggataaaa    180
 aatgattaaa aaattagaaa gtttgtacca attttaacta atgaaaatgt ttgcattggc    240
 tgggcacagt ggctcatacc tataaatccc agcattttgg gaggctgagg tgggaggatt    300
 gcttgagtcc aggaattcaa gactggtctg agcaacatag tgagacctcg tctctacaaa    360
 aaaatatttt ttaaaaatta gccggacatg gntgctcatg cctgtggtcc tagctactcg    420
 ggaggctgag gtgggaggac cgcttgagcc caggaggtgg aggctgccat aagccatgtt    480
 cataccactt cactccagcc taggtgacag agtaagaccc agtctcaaac aaaaaa        536



      <210> 1581
      <211> 5737
      <212> DNA
      <213> Homo sapiens


      <400> 1581
 tttttttttt ttgcaacaat ttaaaaattt attgcattac agtagcatca catcagcagt     60
 caataatgcc actttaagca aaagtctttc agtatttccg ttacacattc tgttaacaag    120
 aactcataca ttggtaaaat tcattttaag aaaacttggc aaataacgct ttggcctgta    180
 attggcattt ctttctctac ttttccttcc caccatttct tccttttaaa ctacaggatt    240
 tatattttaa aatgttttat ttcagaacat taagatagca gttacatttt ttaatattta    300
 tattatttta aaatgactct ttaagataca gttttaaacc catgggctag aaatcatacg    360
 actgttaatt agccgcatta tttggtctaa cattttttat cattctgaaa ctggatttgt    420
 gtaatacatt gataaattca tacaatttgg aagagtcagt tgaagttaca aggacccaat    480
 atctgccctc tttcagtgaa tgccggcaaa tctgttattc cattggcaaa atcgtattgc    540
 tgctctcctg ttaatctcac atttataaaa ggatcatgag gctgccaagt gctaaaaatg    600
 gagatggtct agtaactaga aaactcccca ccccagggag cacacctaca tatctcccta    660
 caacctaata atgtgatgtg ttttggaaca cagacattag aacttcatga agttttaact    720
 gttgattctt tcccaagcat catcaagtta tgatttaggc aatgtatgat tgaaatgcat    780
 tcattcatca tgcataggca caatcacaga aatattgcac aaagtatgtc cctgactgaa    840
 aatgagaggt acaaaaacgt atttcactct tcgtaaagaa gtttgtgagg aaatacaact    900
 ctgcgatcgt atagacatgt ttcctgataa tacagacatt cacaaacagt agattgcacc    960
 acagtgtgta aacattttaa gttgcataaa cttctccttg attttcaaag ataatataat   1020
 actgtctact aaaattcctt tttgtttcaa ctaagtactc tcacatatat tagtttataa   1080
 taatgtttgt tattactttc taaagtgttt tccactcaag gaaaagaagt aaattcctat   1140
 gtcagagtaa ccgaggtggt tgaagaatag gtattagcca gagaggtcta gatagtaaaa   1200
 tcaaacttca agcctcaaag aagctccatg aacagagagg aatgccaggt gtcacacagc   1260
 tttccttcac tctaattcat tcttgactag agcctgtatg cctgattcag agacatttaa   1320
 actcttaaag gatttcttat gatcttcact aaatacatta agaagaatgc caaccagcgc   1380
 cctttcgtgt actgggacag gtagtcatgt gattaaaaca gggaacacga actctgactt   1440
 taaaatgtat tgtagataca aatgctctaa gctaggaaag gtttttcaca cccacagcca   1500
 atgatggcag cctttcattc ctcggaaata agcccttttt gaggtcattg aaaaaagagt   1560
 gcaactgctg cagctcacga tgcaatatct tcatgagccc agagcacata caaatccaaa   1620
 gggaactgcc acagtacact gctcattctt ggcaccggaa cagatgaaac acactgtatc   1680
 ctgcacatac ctgccagagc aggccacttt cctcttctgt gagatttaga aagctccccc   1740
 aaaaggttat cactcccatc accaatacac agaaaatgga ggaaaggctg tttccagttc   1800
 tcggccttta aacagctcta aatgtcagta ctccacagtg gcatattaca aagtaataaa   1860
 cagtgccaca cttgagggca aaccgcatat tgagctatag aagagctcac tgtgattaag   1920
 atgagatcaa acatcatagc agaacattag caaattttat ctgaattctg taatggacat   1980
 ccatgctgca ataacattag aaaagcacgg gagcctattc caaaccagcg agaacagttt   2040
 tgtgcaaaga gtgggtcttt gtgtgtttga actcccacca cgtaagggca aactcgatat   2100
 gcatgctaat gacctacaat tatgaaatga aaaaagaaaa atgctgaagg atgccagagt   2160
 gaacatcagt gagagccaca gagacccact ctcttttaac tttttacaaa taaacttaaa   2220
 ctataaatga gaaccacaaa taatcatgag tagctctaac attcaaatga agtaaatgaa   2280
 ttgtgtagga gattaacccc ataactgtgt ttcgtttttg aaaatgtctt gagcagctct   2340
 ttgatgatgg tggtgtttat ctccttcttc tcggcagcca agcccagcaa aagcatggca   2400
 cacagcagtt gctgcccaag cctgggtgct cctggtggtc ctgcatctca ccaaggagct   2460
 gcacgattgg ctgttgcagt agggttgtcc tgggaagaac cctccctggc ttctccttgt   2520
 gcaggctcca cgctgttggt gaggctcgcc tcacaaagat caccatgctt gtcggcagcc   2580
 ccgagctcct ggggggctgg ggctcctgga ctgggttcag cagcagggtt ctgggcagcg   2640
 gccaggaatt tgccgtgccc ctcgctgtag ctgccacaag ccgcaacacc atctcctgca   2700
 gctccagcag cttcaccttc ctctcctcct tgtcctgggc cagcctgatg atggcctcct   2760
 cccggtgacg catctttggc actgtcccct ggctctgtta gaaggcgatg tacgttctga   2820
 tggcatctct ctctccggta ctggatgaat ccaagttcca gtttctccac atgctccctc   2880
 aggtccgcct tctcctccag gaggtccata aggccgctag actcgccccc agtccctgag   2940
 gctgggactg ctgcctctgg ctccttctcg gccgaggtga gcgtctccat cacctggccc   3000
 agcttctcct gcagctcctt tacttgctgc tccaactgca gtgcgctctt gttctcgtgc   3060
 ttcagctcct ccaagtcgct ctgtggctcg gccagctgct gaagcctctt ctcccgttcc   3120
 cgaagcctct cctgctgctc ctgaagcctc tcctcctgct cgcgaagcct ctcccttttg   3180
 cccacggttc aggagactga tgcactgatt gttttccacc tgagcctgga gctctcctgc   3240
 cactctctcc agctccttcc tcaggtcttg cagctccacc tcagaggaca ctgctggggc   3300
 atccgggggc agtggctcag ccatctggtt tttgagtctg gacaagctcc tctccagctc   3360
 ctctacccga tgcgtatcat gcttcttctc ctccttcaat gtgcaaacct cctgcgacat   3420
 tttcctcatc ctctgctgcc actgggccct ctctcctttt atttgttcag catattgatc   3480
 tctctccagc tggacttctt taagcgactc cttcaactgt gtcacgtgtc ctttcagcag   3540
 tatctgctcc cgtatggact gctctaactg ccgcttgaga agtgctttac tgcggctcga   3600
 gaacccatcc ggcttcttct tctgtgtggc ggcgacagca cagagagacc actctaactc   3660
 tcctatacgc tgcgatgaac gttgcaggcg gccggccaga tccttggact cttcttcaaa   3720
 gtatctgaga gaatgtttca tgtgatacag gtccgtattt agtttctttt tctctatgtt   3780
 caatctctgg atttgaccct ctagctccct ttcagctttc tgtttctcat tgtttgcttt   3840
 cttttcttct tccagctgat gttccacttg tttcttctgt tgtttcaaag atttgatggt   3900
 gtcattcagt cgactgattt ttatggacct cgagttcagg actgctgctt gttcttggca   3960
 cgggctctga cgcgcatgca gagaggagga ggcggaggag gacttggggg agaggtagag   4020
 agaacgatca ttagggctgg gttgtgtgtg ggctgtctca gctggcagag gggcacccag   4080
 tccccgctgc gggaggaggt tggagggctg gcctgcgggg tcactgcacc tccgcccaga   4140
 gcctcctacc tccagatcct tcagggtagc agatgatgta gggccctccc cgtggatacc   4200
 tgttgctgac tataagagat gagactgcac atggagatgt tctgtccccc tcagtgtctg   4260
 agccctccga cttcctttct tccccatcaa ctggcaacat tttcttttct gcctatcttg   4320
 gaccctttgt cccataactc ctttgtgcca acttctctca cggttcttat ctccccacca   4380
 tcccaccctg ggggccttgc agtgactcat gatgggaagt ggctgttctc attgtcctgg   4440
 cttccccttg agactgggga tgaggaaaat caaacagcaa agaccatatc ctgggtgtcc   4500
 tgggtgttga cagcaggcca tgtactaggg attaacataa aatcgacaat tatcaatctc   4560
 attgaaactt cacaaataca agtcaaacaa taccacctct atcatacaga cgtgaaaaca   4620
 gaggcccaaa gagctcaagc aacttgccct aaatcatatc cctagcagac ggagaggcag   4680
 gattcaaacc cagaattctt ttcttttttg aaacggagtc tctctctgcc ttccaggctg   4740
 gagtgcagtg gcgtgatctt ggctcactgc aagctccgcc tcctaggttc acgccattct   4800
 cctccctcag actccggagc agctgggact gcaggcgccc gccaccacgc ccggcttttt   4860
 tttttgtatt ttttagtatt tcaccgtgtt tgcctggatg gtctcgatct cctgaccttg   4920
 tgatccacct gcctcggtct cccgaagtgt ggggattaca ggcgtgagcc actgtgcccg   4980
 gccaaatcca gaatccttca ccagtaccca acagtccatc cacaatctta acgattgccc   5040
 tctactgctc cttgggcccc ctgtccccaa aagcctgtcc aggcaagact cacagcttca   5100
 gatgagtggc aaccaccaga agcggccgtc tcagggctac tgccatttgc tttcgtgttc   5160
 ctcttcgctg ctgctggaac accagggcgg tttctctgcc aatattcttt gaactttttc   5220
 ttggctgcag ctaatttact ctgtccagtt tcttctgcca ttgtggggtg gggagggagg   5280
 cggggctggg gccacgtcag ccaaatccca gcgagcgctg atcaacacgt ccagtcaccc   5340
 ttaaagaatc agaaataaat aggctgggca tggtggctca tgactgtaat cccagcactt   5400
 tcgggaggcc aaagtgggcg gatcacctga ggtcagtagt tccaagacta gcctgcccaa   5460
 catggtgaaa ccccgtctct actaaaaata caaaaaatag ctgagcatgg tggcagaggc   5520
 ctgtaatctc agctactcgg gtggctgagg caggataatt gcttgaacct gggaggcaga   5580
 ggttgcagtg agctgagatc gtgccattgc actccatctt gggtgacaga gtgagacatc   5640
 atcttctttg ctccaagctg cactctggct ttgcctttga gtcacgtggc atttctttgt   5700
 acgatgaccg gttctgtcga gtaggcactg cttcagc                            5737



      <210> 1582
      <211> 2520
      <212> DNA
      <213> Homo sapiens


      <400> 1582
 gggcggcgcg ctgcagtgcg gggacccgct cgctcgctcg ccagccgtcc ccgcgccccg     60
 cgtccccgcg cagccgcctc ctggcctcgg gcgccgcgca tccaggaagg aagcagccac    120
 cctcgccatg gcctccccgc ccgcctgccc ctcggaggag gacgagagcc tgaagggctg    180
 tgagctgtac gtgcagctgc acgggatcca gcaggtcctc aaagactgta tcgtccacct    240
 ctgcatctcc aagcccgaac gccccatgaa gttcctccgg gagcacttcg agaagctgga    300
 gaaggaagaa aacaggcaga ttttggcgcg gcaaaagtca aactcacagt cggactccca    360
 tgatgaggag gtgtcgccca cccccccgaa ccctgtggtg aaggcccgcc gccggcgagg    420
 aggcgtgagt gccgaggtgt acaccgagga ggacgccgtg tcctacgtca ggaaggtgat    480
 tcccaaggac tacaaaacca tgactgcgct ggccaaggcc atctccaaga acgtgctctt    540
 cgctcacctg gatgacaacg agaggagtga catattcgat gccatgttcc ctgtcactca    600
 catcgctggg gagactgtta tacagcaagg gaatgaagga gacaacttct atgtcgttga    660
 tcaaggggaa gtggatgtgt acgtgaacgg agagtgggtg accaacatca gcgagggagg    720
 cagcttcggg gagctggcgc tcatctacgg cacccccagg gctgcgaccg tgaaagccaa    780
 gacggacctc aagctctggg ggatcgaccg ggacagctac cggcgcatcc ttatgggcag    840
 cacgctgagg aaacgcaaga tgtacgagga gttcctcagc aaggtctcca tcctagagtc    900
 cctggagaag tgggagcgtc tgaccgtggc ggatgcgctg gagcccgtcc agtttgaaga    960
 tggagagaaa attgtggtcc agggagagcc tggggacgac ttttacatca tcacggaggg   1020
 caccgcgtcc gtgctgcagc gccggtcccc caatgaggag tacgtggagg tggggcgcct   1080
 gggaccctct gactacttcg gggagattgc actgctgctg aaccggcccc gggcggccac   1140
 tgtcgtggcc cgggggcccc tcaagtgtgt gaagctggac cggccccgct tcgagcgtgt   1200
 gctggggccc tgctctgaga tcctcaagag gaacattcag cgttacaaca gcttcatctc   1260
 cctcaccgtc tgagcacagc tcccgccctg cagccccagc tccccagtgt ggtggccgtg   1320
 ccctgctcgt ctgtgtcggg ggcccgggag ccgctgtgtg aggtgtgggc cgggtggggc   1380
 tgggtcccgg cagcgtgagg actgcccctt ccccggactc actttttgga ataaatgatc   1440
 accttgtgca tttccaaatc aaaggacaag cggacaaaat gcatcccaag atcaaggaag   1500
 ggacaggcca gcttcctccc cacacgcctc cccggctgcc tctgtgggct tctcctgggg   1560
 ggcccacccc acccctgcca gtctcctgga gatgcttgag gatcggtcct ccccagaacc   1620
 aggccaggac gttgcccctg gggcctggtg accctgtgag gtcaggtccc ccagattgag   1680
 gtctgagtgt gggcaagtgt gtcaaaaggg gctgcccccc aggggagatg aggctgagag   1740
 cagggagttg aggccgaaga agtcaaggcc cctcccgcaa atgtgtaccc ctgcccgcgc   1800
 cactgcaccc cgccgcaccc ccacctcccc cgggggccct gctgcggatg ccggagtggg   1860
 agagtctctg agctgtgaga ttgatcttgc ccctaattgg agaggaagcc gggcgccaag   1920
 acacacgggg ctcctgcctt gggagccagg gccgcggccg caggtagacc ccagtagggg   1980
 gggccgggct cgaagttcct ttgggagggg ctggcgggac tccagcaggc cgtcctcacc   2040
 tttcttagaa agtccaccca gggcaagttg atgttggggg aaagcagaag tcaagccagc   2100
 cgcgggcccc acacgccctg acccgctcaa ccgacttgtc ccttaaatgt gtcttggatc   2160
 ccgcagtgat gacgtgagcc agccaggccc gaaagggtga ggccagtgca gagaagcttc   2220
 ccaggggatt cctgggttcc cccgaaagac aagcgaggtc attgcagttc acccgatgtt   2280
 gctcctgtcc cgtgcgtccc ggggaggctg tccttggtcc gaggctgctc gttgcagccc   2340
 ctcccctgct ggcggttacg atgcgtgggg tccccctccc cacccagccc cggccacgtc   2400
 gccgtgtccc gcctgtgcct gtgacgtccc tgtggacctg tgagccatcc ccccccttat   2460
 ctctgctctg aatactgcat gaagcattaa acgtgcaatg aagcggacgc gtgggtcgac   2520



      <210> 1583
      <211> 585
      <212> DNA
      <213> Homo sapiens


      <400> 1583
 cccacgcgtc cgctggaacg aggcccctcc gggctgggga tgggcctgat cgacgggatg     60
 cacacgcacc tgggcgcccc cgggctctac atccagaccc tgctcccggg cagccccgca    120
 gcggccgacg ggcgcctgtc gctgggggac cgtatcctgg aggtgaatgg cagcagcctc    180
 ctgggccttg gctacctgag agctgtggac ctgatccgtc atggcgggaa gaagatgcgg    240
 ttcctggtcg cgaagtccga cgtggaaaca gccaagaaga tccatttccg cacgccccct    300
 ctctaggggg gctgcgagga cacccccaca ggcccggcac ccggtcccac ctggtgacac    360
 tgggcttcct cccgccttcg tccctgtttt gtaactgacc aagttgggtc ccgggtgggg    420
 agcctcaccc tggggacatg cctgttgata acatgcatct cagtgtaggt tctatttata    480
 tggcagatga cgtgaaattg tgatgtttgt tacagagctt ttatgtttaa agacttcaat    540
 ggagaagtac ggttcaataa actatttttc ccgttaaaaa aaaaa                    585



      <210> 1584
      <211> 2227
      <212> DNA
      <213> Homo sapiens


      <400> 1584
 tttttttttt tccgttttgt tatttaatca tatattttta cttgtatcta agccaggtcc     60
 tttggcaatg aggaggtgtg cagggatcgg ggtgaggaag tgcaggactg gatggacatt    120
 taaggtaggg cagctttggg ggatgccact tccaaatgca atggggacca tcactgtgta    180
 ttccccatag ttgtgtggtg agcagctctg gataccctga ccacaaagct ttggggacaa    240
 tttgttcacc agaagatgtg aggaggacgg aatactcaaa ggcactcaga gatggtggag    300
 ctttggagct gaggcgggca aggcatctca gatggtcacg ctgtttctct accatgctgg    360
 gtcaaaggta ctcacacggc aggttcagga ctgcattccg gacctcaatc tccttgtcca    420
 tggaagccag ttcctcctgg aattgtctca gcacagcttg gggctcagga ccagagaaat    480
 atttctcctc atgcatgaca ggctggcgtc tgccaaggaa ctttgtgaag gtcttttgca    540
 tacgtgcctg gtggagattg ggcagtaagt ccactatatc cttctctgtc acatccttag    600
 agatgggcgg gggcttctgc atggtgcatg ggccattagg gatccaggag taccagtcca    660
 gctggcccag gtggttagaa gcatgctgac ctgtgcatgt gaagatgcac atggtgacaa    720
 agtggcagag ctgagcccgg gactctaagg agatgaggaa cccctggtct tgggccctct    780
 gcagtccagt ctcagtcatc tctctgcacc aggcctgcag ctctagatca tccttcatgg    840
 cttggtcact attgtagaaa agcccaacca tcccctccac gtacctattc ccggctgatg    900
 attccccaca gcctgatggc atcttagcca taaaaagaag atttcacatc caggagccca    960
 cggtcagcca ggtcatcagg aggacagagg gaatgatagg tcaaacaagc catggctctc   1020
 tgaagaatgt ccacgtggct tccactacca gtgctcacca ccaggtcaaa aattccccat   1080
 tcggagacaa gactactctg ggccagcgtg ttgatcgcca tggtgtagcg gaagtggggg   1140
 atcaggagct tgtagatagg atggaggcta ggcaagcttc tcattgtagc cacagcaata   1200
 acctcagcaa tcaagtgtcc cctcagcaga tgtgactgta actgctgcag ctggaaatca   1260
 gagctccgga cccaggtctt ggccaggagc caggccatgg ggggatgcga gggcagaaag   1320
 agcagaggtg ggggacatcc gtgtcaaggt ggctggagct ggatgaccat gggtaagagt   1380
 cctccatcag gctgaagctt cagcacgacc aaaggggctg ccacgcattg ctgcttaaaa   1440
 atgatgacat taggcttgac tccatccagc aaggagaaat ccacttcaaa cagagatcca   1500
 gcctggagtt ctttctccag ctgggtcttc aagtcttcca tccctggagg cagcaccagg   1560
 caggctggga gccttgaaga acacctcagg agcatggggt ttgcaccatt gagaaactgg   1620
 tacccaaaga aggcatcatt cttccaagaa tcataaaccc gctcagccag gacagtcttt   1680
 ccatgtggga atattttttt gaaatcttcc agccttttca cacaatttat gaaatccagt   1740
 gtccccttaa tggccaagtc cttcaaccct tttgctaggg agacattaaa gtctaaatcc   1800
 ttatcctcga ggaatcgctc gtccctagga aggtccggtt gcctattccc tgctataggc   1860
 aggattaacc catctttcca ggagccccac cagtaccctc aggcaggcag ataattccgt   1920
 ggccctgcac ccagcggtag caggggaaaa aggccgcgcc ttgggtcccc gggccctgca   1980
 ctgagatcca cttgcagaac cagtcgagac tcaacagcac gttgtgtttg cgcagcttca   2040
 ccatcaggag gcgccccagg tgcaggggga cgtcgatctc aaactctgcc tcctttcccc   2100
 acaccggtgg cagctgcttc cctaggtctg cctccccgtg ctcgcccacc agccatagct   2160
 gcaccaggtt gggagagccc gccaggagca aatccccggt ggctacgcgg accgtgtact   2220
 tgcccat                                                             2227



      <210> 1585
      <211> 2227
      <212> DNA
      <213> Homo sapiens


      <400> 1585
 tttttttttt tccgttttgt tatttaatca tatattttta cttgtatcta agccaggtcc     60
 tttggcaatg aggaggtgtg cagggatcgg ggtgaggaag tgcaggactg gatggacatt    120
 taaggtaggg cagctttggg ggatgccact tccaaatgca atggggacca tcactgtgta    180
 ttccccatag ttgtgtggtg agcagctctg gataccctga ccacaaagct ttggggacaa    240
 tttgttcacc agaagatgtg aggaggacgg aatactcaaa ggcactcaga gatggtggag    300
 ctttggagct gaggcgggca aggcatctca gatggtcacg ctgtttctct accatgctgg    360
 gtcaaaggta ctcacacggc aggttcagga ctgcattccg gacctcaatc tccttgtcca    420
 tggaagccag ttcctcctgg aattgtctca gcacagcttg gggctcagga ccagagaaat    480
 atttctcctc atgcatgaca ggctggcgtc tgccaaggaa ctttgtgaag gtcttttgca    540
 tacgtgcctg gtggagattg ggcagtaagt ccactatatc cttctctgtc acatccttag    600
 agatgggcgg gggcttctgc atggtgcatg ggccattagg gatccaggag taccagtcca    660
 gctggcccag gtggttagaa gcatgctgac ctgtgcatgt gaagatgcac atggtgacaa    720
 agtggcagag ctgagcccgg gactctaagg agatgaggaa cccctggtct tgggccctct    780
 gcagtccagt ctcagtcatc tctctgcacc aggcctgcag ctctagatca tccttcatgg    840
 cttggtcact attgtagaaa agcccaacca tcccctccac gtacctattc ccggctgatg    900
 attccccaca gcctgatggc atcttagcca taaaaagaag atttcacatc caggagccca    960
 cggtcagcca ggtcatcagg aggacagagg gaatgatagg tcaaacaagc catggctctc   1020
 tgaagaatgt ccacgtggct tccactacca gtgctcacca ccaggtcaaa aattccccat   1080
 tcggagacaa gactactctg ggccagcgtg ttgatcgcca tggtgtagcg gaagtggggg   1140
 atcaggagct tgtagatagg atggaggcta ggcaagcttc tcattgtagc cacagcaata   1200
 acctcagcaa tcaagtgtcc cctcagcaga tgtgactgta actgctgcag ctggaaatca   1260
 gagctccgga cccaggtctt ggccaggagc caggccatgg ggggatgcga gggcagaaag   1320
 agcagaggtg ggggacatcc gtgtcaaggt ggctggagct ggatgaccat gggtaagagt   1380
 cctccatcag gctgaagctt cagcacgacc aaaggggctg ccacgcattg ctgcttaaaa   1440
 atgatgacat taggcttgac tccatccagc aaggagaaat ccacttcaaa cagagatcca   1500
 gcctggagtt ctttctccag ctgggtcttc aagtcttcca tccctggagg cagcaccagg   1560
 caggctggga gccttgaaga acacctcagg agcatggggt ttgcaccatt gagaaactgg   1620
 tacccaaaga aggcatcatt cttccaagaa tcataaaccc gctcagccag gacagtcttt   1680
 ccatgtggga atattttttt gaaatcttcc agccttttca cacaatttat gaaatccagt   1740
 gtccccttaa tggccaagtc cttcaaccct tttgctaggg agacattaaa gtctaaatcc   1800
 ttatcctcga ggaatcgctc gtccctagga aggtccggtt gcctattccc tgctataggc   1860
 aggattaacc catctttcca ggagccccac cagtaccctc aggcaggcag ataattccgt   1920
 ggccctgcac ccagcggtag caggggaaaa aggccgcgcc ttgggtcccc gggccctgca   1980
 ctgagatcca cttgcagaac cagtcgagac tcaacagcac gttgtgtttg cgcagcttca   2040
 ccatcaggag gcgccccagg tgcaggggga cgtcgatctc aaactctgcc tcctttcccc   2100
 acaccggtgg cagctgcttc cctaggtctg cctccccgtg ctcgcccacc agccatagct   2160
 gcaccaggtt gggagagccc gccaggagca aatccccggt ggctacgcgg accgtgtact   2220
 tgcccat                                                             2227



      <210> 1586
      <211> 2227
      <212> DNA
      <213> Homo sapiens


      <400> 1586
 tttttttttt tccgttttgt tatttaatca tatattttta cttgtatcta agccaggtcc     60
 tttggcaatg aggaggtgtg cagggatcgg ggtgaggaag tgcaggactg gatggacatt    120
 taaggtaggg cagctttggg ggatgccact tccaaatgca atggggacca tcactgtgta    180
 ttccccatag ttgtgtggtg agcagctctg gataccctga ccacaaagct ttggggacaa    240
 tttgttcacc agaagatgtg aggaggacgg aatactcaaa ggcactcaga gatggtggag    300
 ctttggagct gaggcgggca aggcatctca gatggtcacg ctgtttctct accatgctgg    360
 gtcaaaggta ctcacacggc aggttcagga ctgcattccg gacctcaatc tccttgtcca    420
 tggaagccag ttcctcctgg aattgtctca gcacagcttg gggctcagga ccagagaaat    480
 atttctcctc atgcatgaca ggctggcgtc tgccaaggaa ctttgtgaag gtcttttgca    540
 tacgtgcctg gtggagattg ggcagtaagt ccactatatc cttctctgtc acatccttag    600
 agatgggcgg gggcttctgc atggtgcatg ggccattagg gatccaggag taccagtcca    660
 gctggcccag gtggttagaa gcatgctgac ctgtgcatgt gaagatgcac atggtgacaa    720
 agtggcagag ctgagcccgg gactctaagg agatgaggaa cccctggtct tgggccctct    780
 gcagtccagt ctcagtcatc tctctgcacc aggcctgcag ctctagatca tccttcatgg    840
 cttggtcact attgtagaaa agcccaacca tcccctccac gtacctattc ccggctgatg    900
 attccccaca gcctgatggc atcttagcca taaaaagaag atttcacatc caggagccca    960
 cggtcagcca ggtcatcagg aggacagagg gaatgatagg tcaaacaagc catggctctc   1020
 tgaagaatgt ccacgtggct tccactacca gtgctcacca ccaggtcaaa aattccccat   1080
 tcggagacaa gactactctg ggccagcgtg ttgatcgcca tggtgtagcg gaagtggggg   1140
 atcaggagct tgtagatagg atggaggcta ggcaagcttc tcattgtagc cacagcaata   1200
 acctcagcaa tcaagtgtcc cctcagcaga tgtgactgta actgctgcag ctggaaatca   1260
 gagctccgga cccaggtctt ggccaggagc caggccatgg ggggatgcga gggcagaaag   1320
 agcagaggtg ggggacatcc gtgtcaaggt ggctggagct ggatgaccat gggtaagagt   1380
 cctccatcag gctgaagctt cagcacgacc aaaggggctg ccacgcattg ctgcttaaaa   1440
 atgatgacat taggcttgac tccatccagc aaggagaaat ccacttcaaa cagagatcca   1500
 gcctggagtt ctttctccag ctgggtcttc aagtcttcca tccctggagg cagcaccagg   1560
 caggctggga gccttgaaga acacctcagg agcatggggt ttgcaccatt gagaaactgg   1620
 tacccaaaga aggcatcatt cttccaagaa tcataaaccc gctcagccag gacagtcttt   1680
 ccatgtggga atattttttt gaaatcttcc agccttttca cacaatttat gaaatccagt   1740
 gtccccttaa tggccaagtc cttcaaccct tttgctaggg agacattaaa gtctaaatcc   1800
 ttatcctcga ggaatcgctc gtccctagga aggtccggtt gcctattccc tgctataggc   1860
 aggattaacc catctttcca ggagccccac cagtaccctc aggcaggcag ataattccgt   1920
 ggccctgcac ccagcggtag caggggaaaa aggccgcgcc ttgggtcccc gggccctgca   1980
 ctgagatcca cttgcagaac cagtcgagac tcaacagcac gttgtgtttg cgcagcttca   2040
 ccatcaggag gcgccccagg tgcaggggga cgtcgatctc aaactctgcc tcctttcccc   2100
 acaccggtgg cagctgcttc cctaggtctg cctccccgtg ctcgcccacc agccatagct   2160
 gcaccaggtt gggagagccc gccaggagca aatccccggt ggctacgcgg accgtgtact   2220
 tgcccat                                                             2227



      <210> 1587
      <211> 1110
      <212> DNA
      <213> Homo sapiens


      <400> 1587
 atgggacttc tgatatgtct tggagccttg gatgccaggc cggagcgggc tccctcagct     60
 tgcggggagg tgtggaggga gaggcgtggg cgggaaccgg ggctgcccac ggtgcttgcg    120
 ggccagcgcg agttctgggt gggcgtgggc tcggcggccc tgcactcgga gcggccggct    180
 ggccccacca ccccgggcag taaggggctt agcacccagg tcagcagctg tggaggacgc    240
 acagggtccc ccagcagtgc cagcccactg gcgctgcgct cgatttctcg ctggggcctt    300
 agccacctcc cccatggggc agggctccgg acctgcagcc ccgccatgcc taaacctccc    360
 cactccgccg tgggctcctg tgccacccga gcctccctga tcagcactgc cccccgctcc    420
 agggcgcctg gtcccatcga ccacccaagg gctgagacct gccaacgcac agtgcaggaa    480
 ttggcaggca gctccacctg cagccctgtg caggatccac tgggtgaagc cagctgggct    540
 cctgagtttg aagggagcgg gccaaagcgc agagccaatg ggcgcggggc ttacggtctc    600
 cgggatacgg gtgtacacag cagcggcgtc gcggcccgca gccccgcggc ggcggaaaga    660
 tgggtgcaag gattccctaa gcagaatgtt cattttgtca acgacaacac catttgctac    720
 ccttgtggga attatgtaat atttattaat attgaaacca agaaaaagac tgtactgcag    780
 tgtagtaatg gaattgtggg cgtcatggca actaacatcc cctgtgaagt tgtggctttt    840
 tctgaccgga agctaaaacc tctcatctac gtatacagct ttccaggatt gaccagaagg    900
 accaaattga aagctgacca ggagagggac ccctttttgt acctcttcca ggttgctgaa    960
 ttcctgacgc agggctgcct tcagatcagt gcattctctc ccacatctca acgctaccag   1020
 gcactccttg gtcaaatgtg ggacctaatc agaggacaca ggttctcagt ggagaagtct   1080
 gtggaaactt ccagttcctg ttctgcctga                                    1110



      <210> 1588
      <211> 963
      <212> DNA
      <213> Homo sapiens


      <400> 1588
 tttcgtccgg cgggtcggtg agcgcggccc gggccggaca tggcggcgct ctacgcctgc     60
 accaagtgcc accagcgctt ccccttcgag gcgctgtctc aggggcagca gctgtgcaag    120
 gaatgtcgga ttgcacaccc tgttgtgaag tgcacctact gcaggactga gtaccagcag    180
 gagagtaaaa ccaatacaat atgcaagaaa tgtgctcaga acgtgcagtt gtatggaacg    240
 cccaaacctt gtcagtattg caacataatt gcagcattta ttgggaataa atgccagcgc    300
 tgcacaaatt cagaaaagaa gtatggacca ccctattctt gtgaacagtg caagcagcag    360
 tgtgcatttg acaggaaaga tgatagaaag aaggtagatg ggaaattgct gtgctggctg    420
 tgcacacttt catacaaacg ggtccttcag aagaccaaag agcagaggaa acacctgagt    480
 agctcttctc gtgctggcca ccaggagaag gagcagtata gtcgcctgag tggggggggc    540
 cattataaca gccagaaaac actttctaca tcttcaattc aaaatgaaat cccaaagaaa    600
 aagtccaagt ttgagtcaat cacaactaat ggagacagct tctccccaga cctggctctg    660
 gactcaccag gcactgacca ctttgtcatc attgcccaac tgaaggaaga agtggctacc    720
 ctgaagaaga tgttgcatca aaaggatcaa atgattttag agaaagagaa gaagattaca    780
 gagttgaagg ctgattttca gtaccaggaa tcgcagatga gagccaaaat gaaccagatg    840
 gagaaaaccc acaaagaagt cacagaacaa ctgcaggcca aaaaccgaga gctcctgaag    900
 caggcagctg ctttgtccaa gagcaagaag tcagagaagt caggagctat aacctctcca    960
 tga                                                                  963



      <210> 1589
      <211> 1017
      <212> DNA
      <213> Homo sapiens


      <400> 1589
 tttttttttt tctcatgtga agagattctt tatttgattt tcatcacctt tcaatgaaag     60
 agtgggtcct gtcagcacta cgtaaaatat atatcttaag agcattaatt tctttttaaa    120
 tgaaagacag tgaagaaagt ctgtgttaga aaaaggcata atagaagctt ggttaaatgt    180
 aagcaggttt ctatcaagta aagaataaaa gtaccattac tccattaaac cagtaataaa    240
 aacatactat tgtggcatgt tctcaaaata ggttgttcat aaaaggtgaa ggcttgttag    300
 gtccttttct tctttttagg tggaccaaat caacatggcg gtggtatcta accatcctgg    360
 ggaagaccat gaggtccaag gggaatgagg aaggcatggg ttgcctaacc tcctatggct    420
 caaaggaggt tcctgggtag gaaataccca cccctgtttt cccagaaggt aagagagata    480
 cataacagtt tccagataca actaacacaa gacctgtgag ggtcatggct ctggccccat    540
 taagtctggg tagctgacat aactttagtt ctcttgggtt ctttctctgg tctcagttcc    600
 cttagcgctg acgatctggc aggaccgtag tcactgggat tgggtattcc aaggcattgc    660
 agtcatccaa caggaatacc aaatctctcc tgcagaacga gttcatgatg gtgtacagct    720
 tccgtgcttt gtccttcaag gaatctacct gggccacttt ccaacacggg ggcgaggcca    780
 caaagtcccg cagcttgtcc agcacacagt aattgtgtat gtccaggtac agcctgggca    840
 ggtatctcac acatggctcc gagggctccg agacctgcag gaggttgaag tcgcgggtga    900
 tctcctggct cagggcccgc atgcgggagt agcaggtcgg gggagtgggc cgcgcggcgg    960
 gggctcccgc caggagcagc agcagcacgg gcagaggccc aggcgtcctc atggtgc      1017



      <210> 1590
      <211> 1017
      <212> DNA
      <213> Homo sapiens


      <400> 1590
 tttttttttt tctcatgtga agagattctt tatttgattt tcatcacctt tcaatgaaag     60
 agtgggtcct gtcagcacta cgtaaaatat atatcttaag agcattaatt tctttttaaa    120
 tgaaagacag tgaagaaagt ctgtgttaga aaaaggcata atagaagctt ggttaaatgt    180
 aagcaggttt ctatcaagta aagaataaaa gtaccattac tccattaaac cagtaataaa    240
 aacatactat tgtggcatgt tctcaaaata ggttgttcat aaaaggtgaa ggcttgttag    300
 gtccttttct tctttttagg tggaccaaat caacatggcg gtggtatcta accatcctgg    360
 ggaagaccat gaggtccaag gggaatgagg aaggcatggg ttgcctaacc tcctatggct    420
 caaaggaggt tcctgggtag gaaataccca cccctgtttt cccagaaggt aagagagata    480
 cataacagtt tccagataca actaacacaa gacctgtgag ggtcatggct ctggccccat    540
 taagtctggg tagctgacat aactttagtt ctcttgggtt ctttctctgg tctcagttcc    600
 cttagcgctg acgatctggc aggaccgtag tcactgggat tgggtattcc aaggcattgc    660
 agtcatccaa caggaatacc aaatctctcc tgcagaacga gttcatgatg gtgtacagct    720
 tccgtgcttt gtccttcaag gaatctacct gggccacttt ccaacacggg ggcgaggcca    780
 caaagtcccg cagcttgtcc agcacacagt aattgtgtat gtccaggtac agcctgggca    840
 ggtatctcac acatggctcc gagggctccg agacctgcag gaggttgaag tcgcgggtga    900
 tctcctggct cagggcccgc atgcgggagt agcaggtcgg gggagtgggc cgcgcggcgg    960
 gggctcccgc caggagcagc agcagcacgg gcagaggccc aggcgtcctc atggtgc      1017



      <210> 1591
      <211> 1017
      <212> DNA
      <213> Homo sapiens


      <400> 1591
 tttttttttt tctcatgtga agagattctt tatttgattt tcatcacctt tcaatgaaag     60
 agtgggtcct gtcagcacta cgtaaaatat atatcttaag agcattaatt tctttttaaa    120
 tgaaagacag tgaagaaagt ctgtgttaga aaaaggcata atagaagctt ggttaaatgt    180
 aagcaggttt ctatcaagta aagaataaaa gtaccattac tccattaaac cagtaataaa    240
 aacatactat tgtggcatgt tctcaaaata ggttgttcat aaaaggtgaa ggcttgttag    300
 gtccttttct tctttttagg tggaccaaat caacatggcg gtggtatcta accatcctgg    360
 ggaagaccat gaggtccaag gggaatgagg aaggcatggg ttgcctaacc tcctatggct    420
 caaaggaggt tcctgggtag gaaataccca cccctgtttt cccagaaggt aagagagata    480
 cataacagtt tccagataca actaacacaa gacctgtgag ggtcatggct ctggccccat    540
 taagtctggg tagctgacat aactttagtt ctcttgggtt ctttctctgg tctcagttcc    600
 cttagcgctg acgatctggc aggaccgtag tcactgggat tgggtattcc aaggcattgc    660
 agtcatccaa caggaatacc aaatctctcc tgcagaacga gttcatgatg gtgtacagct    720
 tccgtgcttt gtccttcaag gaatctacct gggccacttt ccaacacggg ggcgaggcca    780
 caaagtcccg cagcttgtcc agcacacagt aattgtgtat gtccaggtac agcctgggca    840
 ggtatctcac acatggctcc gagggctccg agacctgcag gaggttgaag tcgcgggtga    900
 tctcctggct cagggcccgc atgcgggagt agcaggtcgg gggagtgggc cgcgcggcgg    960
 gggctcccgc caggagcagc agcagcacgg gcagaggccc aggcgtcctc atggtgc      1017



      <210> 1592
      <211> 1017
      <212> DNA
      <213> Homo sapiens


      <400> 1592
 tttttttttt tctcatgtga agagattctt tatttgattt tcatcacctt tcaatgaaag     60
 agtgggtcct gtcagcacta cgtaaaatat atatcttaag agcattaatt tctttttaaa    120
 tgaaagacag tgaagaaagt ctgtgttaga aaaaggcata atagaagctt ggttaaatgt    180
 aagcaggttt ctatcaagta aagaataaaa gtaccattac tccattaaac cagtaataaa    240
 aacatactat tgtggcatgt tctcaaaata ggttgttcat aaaaggtgaa ggcttgttag    300
 gtccttttct tctttttagg tggaccaaat caacatggcg gtggtatcta accatcctgg    360
 ggaagaccat gaggtccaag gggaatgagg aaggcatggg ttgcctaacc tcctatggct    420
 caaaggaggt tcctgggtag gaaataccca cccctgtttt cccagaaggt aagagagata    480
 cataacagtt tccagataca actaacacaa gacctgtgag ggtcatggct ctggccccat    540
 taagtctggg tagctgacat aactttagtt ctcttgggtt ctttctctgg tctcagttcc    600
 cttagcgctg acgatctggc aggaccgtag tcactgggat tgggtattcc aaggcattgc    660
 agtcatccaa caggaatacc aaatctctcc tgcagaacga gttcatgatg gtgtacagct    720
 tccgtgcttt gtccttcaag gaatctacct gggccacttt ccaacacggg ggcgaggcca    780
 caaagtcccg cagcttgtcc agcacacagt aattgtgtat gtccaggtac agcctgggca    840
 ggtatctcac acatggctcc gagggctccg agacctgcag gaggttgaag tcgcgggtga    900
 tctcctggct cagggcccgc atgcgggagt agcaggtcgg gggagtgggc cgcgcggcgg    960
 gggctcccgc caggagcagc agcagcacgg gcagaggccc aggcgtcctc atggtgc      1017



      <210> 1593
      <211> 1017
      <212> DNA
      <213> Homo sapiens


      <400> 1593
 tttttttttt tctcatgtga agagattctt tatttgattt tcatcacctt tcaatgaaag     60
 agtgggtcct gtcagcacta cgtaaaatat atatcttaag agcattaatt tctttttaaa    120
 tgaaagacag tgaagaaagt ctgtgttaga aaaaggcata atagaagctt ggttaaatgt    180
 aagcaggttt ctatcaagta aagaataaaa gtaccattac tccattaaac cagtaataaa    240
 aacatactat tgtggcatgt tctcaaaata ggttgttcat aaaaggtgaa ggcttgttag    300
 gtccttttct tctttttagg tggaccaaat caacatggcg gtggtatcta accatcctgg    360
 ggaagaccat gaggtccaag gggaatgagg aaggcatggg ttgcctaacc tcctatggct    420
 caaaggaggt tcctgggtag gaaataccca cccctgtttt cccagaaggt aagagagata    480
 cataacagtt tccagataca actaacacaa gacctgtgag ggtcatggct ctggccccat    540
 taagtctggg tagctgacat aactttagtt ctcttgggtt ctttctctgg tctcagttcc    600
 cttagcgctg acgatctggc aggaccgtag tcactgggat tgggtattcc aaggcattgc    660
 agtcatccaa caggaatacc aaatctctcc tgcagaacga gttcatgatg gtgtacagct    720
 tccgtgcttt gtccttcaag gaatctacct gggccacttt ccaacacggg ggcgaggcca    780
 caaagtcccg cagcttgtcc agcacacagt aattgtgtat gtccaggtac agcctgggca    840
 ggtatctcac acatggctcc gagggctccg agacctgcag gaggttgaag tcgcgggtga    900
 tctcctggct cagggcccgc atgcgggagt agcaggtcgg gggagtgggc cgcgcggcgg    960
 gggctcccgc caggagcagc agcagcacgg gcagaggccc aggcgtcctc atggtgc      1017



      <210> 1594
      <211> 1005
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1005)
      <223> n = a,t,c or g


      <400> 1594
 ttttttttag cctttgtctc ttctttattt gcggatataa ttatgtaccg cactctaaat     60
 tagagataga tttttttctg atatacattt catcttattc accacgagca caccacacgc    120
 acagtagaac agttccacac ctgataaatt gcacaagatg agagtttaga ttcctgaaaa    180
 ccggcaggca agctggcccc gccgcggctt ctcgccttcc ggcttcgttg aaggaaattg    240
 cccacccaaa atggatttcc cagtcagcct ttcccgctgc agggttgaaa cgtctccgga    300
 atgggaagcg ctcttgctgg aaatggctgg acgctgtaga ttccgagctc tggatggatg    360
 tgaaatattc ccccaaggtc aagttgccac gcctgcgagc tgcgccccct ctccctccct    420
 tcccaacccc ctcgatgact ggaaccaaag tgtcggggcc ccacttggaa ggacagagaa    480
 ccctgcccgc aaatgcaccc cgcctccccc caaaaccagg gtgttgtgga aaagaaagga    540
 caacagaaac gcagacgcga tggatcgtga atccctgtcc cctcccatcc cccccatccc    600
 cgaataatca gaaactagga accagagatg tttaaagctt ggcctcccaa gcgcggcggc    660
 agggcgcact gggctggtgg gggcggggtg aggggagaag ggagagagcg cagaagcgcg    720
 gcgggggctc gcccttgcgc cctagtcctc cgcgttggtt cggtaggctt cgatgaggcc    780
 ctcgagggag tgcacgaagc cggacacgct gcagatgccg ccgatgacga agatggcgac    840
 gtcgaagaag acttggtgcc acagcagcaa gcgccagagc aggcgcaggt gaaagaggct    900
 gggcagcaag aaacagaggc cgggtgaatt ccgccgcnct gtctaaacgt gtctagncga    960
 nggcttcagg gnctggctnn ncnggcctct ccttnnnnan gaaac                   1005



      <210> 1595
      <211> 647
      <212> DNA
      <213> Homo sapiens


      <400> 1595
 gaattcccgg gtcgacgatt tcgtgcggag ggcgaggagg agcagaggag cacacagatg     60
 aagcaggtgt ccacgcgtcc ggccgtccat ccgtccgtcc ctcctggggc cggcgctgac    120
 catgcccagc ggctgccgct gcctgcatct cgtgtgcctg ttgtgcattc tgggggctcc    180
 cggtcagcct gtccgagccg atgactgcag ctcccactgt gacctggccc acggctgctg    240
 tgcacctgac ggctcctgca ggtgtgaccc gggctgggag gggctgcact gtgagcgctg    300
 tgtgaggatg cctggctgcc agcacggtac ctgccaccag ccatggcagt gcatctgcca    360
 cagtggctgg gcaggcaagt tctgtgacaa agatgaacat atctgtacca cgcagtcccc    420
 ctgccagaat ggaggccagt gcatgtatga cgggggcggt gagtaccatt gtgtgtgctt    480
 accaggcttc catgggcgtg actgcgagcg caaggctgga ccctgtgaac aggcaggctc    540
 cccatgccgc aatggcgggc agtgccagga cgaccagggc tttgctctca acttcacgtg    600
 ccgctgcttg gtgggctttg tgggtgcccg ctgtgacgtg taaggtg                  647



      <210> 1596
      <211> 1406
      <212> DNA
      <213> Homo sapiens


      <400> 1596
 aatgtcgtct cgagggcccc gcccgcgccg gtggaggacc tgtccaaagt gtcttacgag     60
 gagctgctgc agtggagcaa ggaggagctg atccgcagcc tgcggcgcgc cgaggcggag    120
 aaggtgagcg cgatgctgga ccacagcaac ctcatccgcg aggtgaaccg ccgcctgcag    180
 ctgcacctcg gcgagatccg cggcctcaag gatatcaacc agaaactcca ggaagacaac    240
 caggaactga gggacctctg ctgtttcctg gatgatgacc ggcagaaagg caagagggtg    300
 tctcgggagt ggcagagact gggtcgctac actgccgggg tgatgcacaa ggaagtggcc    360
 ttatacctgc agaagctgaa agacctggag gtgaagcagg aggaagtggt gaaggagaac    420
 atggagctca ggagctctgt gtgctactag atgaggagaa gggtgcaggc tgcgcaggca    480
 gccgctgctc catcgacagc caggccagcc tgtgccaact cacagcctcc accgcaccct    540
 acgtgcggga tgtgggtgac ggcagcagca cctccagcac tggcagcact gacagcccgg    600
 accaccacaa gcaccacgcg agcagtggca gcccggagca cctgcagaag ccccggagcg    660
 agggcagccc ggagcactcc aagcacagga gcgccagccc cgagcatcca cagaaaccca    720
 gagcctgtgg aaccccagat cgccccaaag cactcaaagg acctagcccg gagcaccaca    780
 aacccttgtg caagggcagc cccgaacagc aaaggcaccc gcatccaggg agcagccccg    840
 aaacgctgcc caagcacgtg ctgagtggga gcccggaaca cttccagaag caccggtcag    900
 ggagcagccc tgaacacgcc aggcacagtg gagggagccc ggagcatctt cagaaacacg    960
 ctcttggggg gagcctagag catctcccca gagccagggg caccagcccg gagcacctca   1020
 aacaacatta tggagggagc cctgatcaca aacacggagg aggcagtgga ggaagtggag   1080
 gcagcggcgg aggcagcagg gagggcaccc tcagacggca ggcacaggag gacgggtcac   1140
 cccatcaccg gaatgtctac agtggcatga acgaatcaac cttgtcctat gttaggcagc   1200
 tggaggcaag agtaagacag ctggaggaag aaaatcgcat gctgccccag gccagccaga   1260
 atacagggcg acctccaact aaaaacagct cacatatgga gaaaggctgg gggtccagag   1320
 cccggcgggt cttgcactgg tggcaagggt gccgaggaat aggacgatgc ctggctactc   1380
 tcacgggttc ttttaggtgg tcatcg                                        1406



      <210> 1597
      <211> 1801
      <212> DNA
      <213> Homo sapiens


      <400> 1597
 tttttttttt ttaaaccaca aatgggggat ttatttctga ctctcagccc gtctctcacg     60
 aagacagagc ctattgacca aaaacttcag gatctgcatc tgagcagatc ccaggaaggg    120
 gaagtcaaag ggcccaggtc agaggcccaa gttcagactt cagcagcaga ctagggtcag    180
 actttaccaa agtcagaact cgaggttcat gtaagtcctt agatcccgct cccaagccct    240
 gtctttcttc ctccctcctt ctctcctccc tccagctcag tgtggccacc cgaggggggg    300
 atctccctcc cagccacagc tcgggtatcc caagctggga aatgtgtcac tcggggctgg    360
 ggtgctgatc tgtagcctag tccttcctgg tccctcttga ggacagtggg gatgggattg    420
 gcacggccct caccccgggg tcccagcccc attcctggct cccagccccc cctcagcagc    480
 agtttgaagc ccgggctgga gatgggcacc ccaagtggaa ggttgggagg ctgaggaccc    540
 tgcgacagtg acagcaggtg agcagtggat gtgcggtggt tggaatcttg gaagtgggtg    600
 tcacagttct cgcagtactg gagggaggga gtaggagacc ggttttccgg gctccttgtc    660
 tctccatggc tctccctgac catgcgggct acctcaggga agccagcttc ttcagcgagc    720
 tgagccgcat ccctgccact cagctcacag acccccaccc aggcagcccc acggcccagg    780
 agatagctca cagctgcccc ctggcccgct cgagcagcac acatcagtgg ggtccaccag    840
 aaggcatccc gggcgttgat attcccccca gctcctcctg cctcatgcgg ttccagcagt    900
 ctcctaagtt ctggcaggtc cccctcctgg gctgccctca gtatccggtg agtcatctta    960
 tcctcagcct caagggatct cccttgtcca tgtcttcctg atgctccttc tgccactgct   1020
 tctgctgctg gtgccttcat tattcttctt ttctttctct ttctttctct ggcaggttca   1080
 gtctgagatc tctgggagtc aggagcgctg ctctcatccc caatcagggc ctcatagaaa   1140
 gctcgggctg cagccccatc cagggtggac tctggcttct cgggctgtgg ctgctgctgc   1200
 ccatccttcc agaggtcgct ggggtcagtg gctggggtga aggtgatgag caagggccgg   1260
 gacatggctt ttgggagaac tgagaaaatg ataccaggca agggaaggat gagacaagta   1320
 agccaagctc gtggtgaccc tgtagcaacc acagcctcag agaccagtag gaaaaaaaaa   1380
 tcagcctggc cctttaagtc ttccgcgatc ccatttcgga gtttcctctt cccaaacaaa   1440
 aatagatggg tcactcccta gaagatctcg gggagagtct cctatacgtg ttgctgtgta   1500
 gcttccgtac cgcaaaatgg cgccattctc tcccctcatg aggcaggagc ccggaggaaa   1560
 cagtatgccc gtcaagggtc tctggcggga ctgattcgca ctaggggccc aacaggcaat   1620
 aaggacccag cggattggcc gaggataggc cagtcccctg ggcagcagcg ccgcgccggg   1680
 actagagggg aacgtgagga gagctgcgga aagagatcca gcctggctcc ctcctttccc   1740
 cgccctaagt cagcctcttc acccagtgag cacaaaactg tattgcccag actcccgggc   1800
 c                                                                   1801



      <210> 1598
      <211> 768
      <212> DNA
      <213> Homo sapiens


      <400> 1598
 gattattaaa gcttcgccgg agccgcggct cgtccttcca ctccgccagc ctccgggaga     60
 ggagccgcac ccggccggcc cggccccagc cccatggacc tccgagcagg ggactcgtgg    120
 gggatgttag cgtgcctgtg cacggtgctc tggcacctcc ctgcagtgcc agctctcaat    180
 cgcacagggg acccagggcc tggcccctcc atccagaaaa cctatgacct cacccgctac    240
 ctggagcacc aactccgcag cttggctggg acctatctga actacctggg cccccctttc    300
 aacgagccag acttcaaccc tccccgcctg ggggcagaga ctctgcccag ggccactgtt    360
 gacttggagg tgtggcgaag cctcaatgac aaactgcggc tgacccagaa ctacgaggcc    420
 tacagccacc ttctgtgtta cttgcgtggc ctcaaccgtc aggctgccac tgctgagctg    480
 cgccgcagcc tggcccactt ctgcaccagc ctccagggcc tgctgggcag cattgcgggc    540
 gtcatggcag ctctgggcta cccactgccc cagccgctgc ctgggactga acccacttgg    600
 actcctggcc ctgcccacag tgacttcctc cagaagatgg acgacttctg gctgctgaag    660
 gagctgcaga cctggctgtg gcgctcggcc aaggacttca accggctcaa gaagaagatg    720
 cagcctccag cagctgcagt caccctgcac ctgggggctc atggcttc                 768



      <210> 1599
      <211> 2801
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2801)
      <223> n = a,t,c or g


      <400> 1599
 ccccccattg ctcgcctgca ggaattcggc acgagccgac gccacatggc ggcgcccagt     60
 ggcgtccacc tgctcgtccg cagaggttct catagaattt tctcttcacc actcaatcat    120
 atctacttac acaagcagtc aagcagtcaa caaagaagaa atttcttttt tcggagacaa    180
 agagatattt cacacagtat agttttgccg gctgcagttt cttcagctca tccggttcct    240
 aagcacataa agaagccaga ctatgtgacg acaggcattg taccagactg gggagacagc    300
 atagaagtta agaatgaaga tcagattcaa gggcttcatc aggcttgtca gctggcccgc    360
 cacgtcctcc tcttggctgg gaagagttta aaggttgaca tgacaactga agagatagat    420
 gctcttgttc atcgggaaat catcagtcat aatgcctatc cctcacctct aggctatgga    480
 ggttttccaa aatctgtttg tacctctgta aacaacgtgc tctgtcatgg tattcctgac    540
 agtcgacctc ttcaggatgg agatattatc aacattgatg tcacagtcta ttacaatggc    600
 taccatggag acacctctga aacatttttg gtgggcaatg tggacgaatg tggtaaaaag    660
 ttagtggagg ttgccaggag gtgtagagat gaagcaattg cagcttgcag agcaggggct    720
 cccttctctg taattggaaa cacaatcagc cacataactc atcagaatgg ttttcaagtc    780
 tgtccacatt ttgtgggaca tggaatagga tcttactttc atggacatcc agaaatttgg    840
 catcatgcaa acgacagtga tctacccatg gaggagggca tggcattcac tatagagcca    900
 atcatcacgg agggatcccc tgaatttaaa gtcctggagg atgcatggac tgtggtctcc    960
 ctagacaatc aaaggtgtcg gcgcagttcg agcacacggt tctgatcacg tcgaggggcg   1020
 cgcagatcct gaccaaacta ccccatgagg cctgaggagc cgcccgaagg tcgcggtgac   1080
 ctggtgcctt tttaaataaa ttgctgaaat ttggctggag aacttttaga agaaacaggg   1140
 aaatgaccgg tggtgcggta acctgcgtgg ctcctgatag cgtttggaag aacgcggggg   1200
 agactgaaga gcaactggga actcggatct gaagccctgc tggggtcgcg cggctttgga   1260
 aaaacaaatc ctggccctgg actcggtttc ccagcgcggt caacgcatct ggaggggact   1320
 ggaggaaacc cccttgttgg aagagattcc aagagaagca cggttttctc tttcccttgc   1380
 cctgactgtt ggagtaaaaa acctcttaaa tccattgtat cagaggtcct tacctctctg   1440
 acagttacaa tgatctttgt atctgaactt tgcacgtctg ccgaaaaatc cgaacctgtt   1500
 gactgggatt tttaacaatc cctttccccc ttttgtgtat tccatattgg ccggccccaa   1560
 ggatgctcgc agaagccagc ccccaacccc agcccttccg tatctttccc ctccatcgcg   1620
 gctttgcgat gaaagattag cccgcgaaca gaggcattga ttacaaacat gtccttggca   1680
 gtggactctg ggcctggcat tcttcaggtt tctgtcaatc cagaaacgcg actttcctgg   1740
 acccctgcgg ctctgtcctt cccgcccaca tccagccctc caaggccagt ccagaggtga   1800
 agtttgaggc cctcccccca cccaccccac acgcacgcag gcacgctaga ccgtttgctg   1860
 cactaggaat tcgagcttgg gccccactcg cccaggtgtg aacagtggct gattagtggg   1920
 cggtctagtc tctaaaatga cccctcccca gactggccct tctcgcatcg ggacccgcgc   1980
 ttgcacgctg caggagccgc aaacgtcagc tgttctggaa accgagaggg tcccagagag   2040
 aggagatacg ggcgcatttg agagcaaggg cctacttggc cgggactgaa gcttgcgagt   2100
 tgagctccag ttcggccggc agttccatcc cgcttcagga acaggaatcc aagggcccac   2160
 gctctgtctg ccaagggcca ttcctgcccg gagcaccctc ctttcccttg cgcttgctct   2220
 ccggtacctg ttccgcacct gagctcaagg gcagggagag gccgggcctc tggcagtcca   2280
 cgaaggaagc cgtctgcctt cggttatgat tttaggaaca agtccaacga gggtgttcaa   2340
 gcagttaatg gttgtgctaa ctcttgtttc tactgaagcg ggttttgcaa agctgacatc   2400
 ccttaaagat aacttgggct ttcggaagcg gcaaggaaat ggcacctgta gttgccagga   2460
 caggtggtgt cctcggccag gactaagagc cagctcatct ttgtaacatt cataatacgg   2520
 gaaactgagg accaggtggc tcggaaaaga gatgagttcc aagcttttac ctaacacagg   2580
 gttctctcgt cgtcccccaa cccctccagc tcggcttctt tgtgtccagg gttgtagatt   2640
 tttggataga ggtgtttctg attctaagtg agtctgagaa ctggaaaaga ccaaggaggg   2700
 gttgatgatt tacnaggtcc atagaaaaac tttttgtgtg gtcggaagtt ggccaagcag   2760
 aggcccacag cctgatgcta ctgcccccac ccccccaaag a                       2801



      <210> 1600
      <211> 2717
      <212> DNA
      <213> Homo sapiens


      <400> 1600
 atagaaaact gatactacgg acataagaat tttaaaaatt tcttttgcca aagctggcta     60
 agggaatatt tttattcttc tgagggcagt taaggcttct gataagaaaa gagagtctga    120
 acagagcaca cacatctgga gctccaggag tgggggatgc agcatcagat tccatcttga    180
 atttctgcta aaatactttg tactcataat ggatctcaac aaagatctgt atttcatctg    240
 tggctccatc ttccctctgg gtcaagtaga tgttaagctg gaccttggca cgcctcttaa    300
 catgaagaga tctagctaga cagacagact cccccattta tggaacaaga attcaattta    360
 ttctctattt ataaaacatt tttttaaagt gccttgggta taaaaatcta aatgtctgcg    420
 gtgtgatcag tcaggagcac gtaactatca ctcttcgcat cctttggtca ctgggagatc    480
 ctttgggggc tgggaggtcc ttctgtccca ggctaaagga aaagcttcac aagggtaaga    540
 gccacagaac cctcggcaag aaaggccggt cagggagaat gaatggtaca gagaggaaag    600
 gaaggaaagg gggtggaaca gaggtagaag gcaaggaagg gatgccgcac tggagaccga    660
 tggggacact ctaattgtgc aagagggagg atcttccttc ttgaatgctg aacacagcta    720
 gtctgaacct tccttggaaa gtccagctgt ttgcccatgc atagggccaa ctctccctgc    780
 aaagcagcaa atgtggcttc tatcaggaag gaaaagtatc catcagtgtg acaagaggtc    840
 accttcgaac ttgcatgaac tccttgcgca gccacaaaga gtcctggtag aagtgaggat    900
 cgcctagtct tacggctgtc cgtttataga agtagcagta caacactgct gctagtctct    960
 ggaatacaaa cagcatttga agtccatctg tccatatgaa gctgttggag tttttccagc   1020
 gtaagttcat gacccagaca tgaagggaga tgctgagggc aaagtacaca gctgtcagga   1080
 tgatggtccc tttgaactta tggaatagga ggttgaccag gccagcctgg aagacgaagg   1140
 tgttgaagaa catgaggaaa atgatgatga tgttgaagag gactgcaata tcctggatga   1200
 tgaagagcac aagctggatg acaggagtct tttggagcag ttctgagaag gaattgacaa   1260
 agaggtcata ggacagcagc aggaactgca gagagagcac caggctgtag ttactggtct   1320
 ggagcatctt ccttctgttt tctcgggccc ccaagggcac atcccacagt tcccagaaaa   1380
 ccgctcctgg ctgtctccct accactgagg gagaggcttc tagttccttt gaatgagagc   1440
 tgtttccctt gctctaaggc aagcacctcc aaactccaac gtcggttgtc atgcggacat   1500
 cgtcccggct tccggaagcc ggctttaaat tccggaagta aatggaggag gcgggccccg   1560
 tctgcgccgt gcggcctgct agtccccggc tttctcttcc cgctctatgg ccagtctggc   1620
 cgccatgttg gagctttcgc tgttcggggc ccggcctgct ccgggccctc ccagcgtcgc   1680
 cgctagctga cttagggctc ccgcccacac tgcgcacggc cttgctgagg gccggctcgt   1740
 agtgggaggc ttcgcgttca cctgaacatt tccgcctcct ctggatgggg gatgagaggc   1800
 ggggctgatg catcgcagca gtcctggacc ctgacttcgg acttggagaa gaaacgccga   1860
 ggaggaacgg gagttagggg gttagcagct tggcgcgctg ggagccggcc acccctggtc   1920
 tccggacttc acttcccagg aggcctcgcg cgcgactgga agtgctgcga gcctataaga   1980
 aggcgaggcg gcacccgccg ctctgctctg gggcggcatt gccagccggc tgtaggcatt   2040
 cagggcagtg tcttctgcat ctcctaggaa cctcgggagc ggcagctccg gcgcctggta   2100
 gcgagaggcg ggttccggag atcccggcct cacttcgtcc cactgtggtt aggggtgagt   2160
 cctgcaaatg ttaagtgatt tgctcaaggt gcccatttcg caggaattgg agcccaggcc   2220
 agttctctga gcctatcatt agggctaaag gagtgcgtga tcagaatggt gtctggacgg   2280
 ttctacttgt cctgcctgct gctggggtcc ctgggctcta tgtgcatcct cttcactatc   2340
 tactggatgc agtactggcg tggtggcttt gcctggaatg gcagcatcta catgttcaac   2400
 tggcacccag tgcttatggt tgctggcatg gtggtattct atggaggtgc gtcactggtg   2460
 taccgcctgc cccagtcgtg ggtggggccc aaactgccct ggaaactcct ccatgcaggc   2520
 tgcacctgat gccttcgtcc tcacattgcc agatgttggc agaagggcta atattgaccg   2580
 tcttgactgg ctggagcctt caaagccact gggatgtcct ccaggcacct gggtcccatg   2640
 accagctccc cgtctccata ggggtaggca tttcactggt ttatgaagct cgagtttcat   2700
 taaatatgtt aagaatc                                                  2717



      <210> 1601
      <211> 6648
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(6648)
      <223> n = a,t,c or g


      <400> 1601
 atggaccagc cagaggcccc ctgctccagc acggggccgc gcctcgcggt ggcccgcgag     60
 ctgctcctgg ctgcgctgga ggaactgagc caagagcagc tgaagcgctt ccgccacaag    120
 ctgcgcgacg tgggcccgga cggacgcagc atcccgtggg ggcggctgga gcgcgcggac    180
 gccgtggacc tcgcggagca gctggcccag ttctacggcc cggagcctgc cctggaggtg    240
 gcccgcaaga ccctcaagag ggcggacgcg cgcgacgtgg cggcgcagct ccaggagcgg    300
 cggctgcagc ggctcgggct cggctccggg acgctgctct ccgtgtccga gtacaagaag    360
 aagtaccggg agcacgtgct gcagctgcac gctcgggtga aggagaggaa cgcccgctcc    420
 gtgaagatca ccaagcgctt caccaagctg ctcatcgcgc ccgagagcgc cgccccggag    480
 gaggcgctgg ggcccgcgga agagcctgag ccggggcgcg cgcggcgctc ggacacgcac    540
 actttcaacc gcctcttccg ccgcgacgag gagggccggc ggccgctgac cgtggtgctg    600
 cagggcccgg cgggcatcgg caagaccatg gcggccaaaa agatcctgta cgactgggcg    660
 gcgggcaagc tgtaccaggg ccaggtggac ttcgccttct tcatgccctg cggcgagctg    720
 ctggagaggc cgggcacgcg cagcctggct gacctgatcc tggaccagtg ccccgaccgc    780
 ggcgcgccgg tgccgcagat gctggcccag ccgcagcggc tgctcttcat cctggacggc    840
 gcggacgagc tgccggcgct ggggggcccc gaggccgcgc cctgcacaga ccccttcgag    900
 gcggcgagcg gcgcgcgggt gctaggcggg ctgctgagca aggcgctgct gcccacggcc    960
 ctcctgctgg tgaccacgcg cgccgccgcc cccgggaggc tgcagggccg cctgtgttcc   1020
 ccgcagtgcg ccgaggtgcg cggcttctcc gacaaggaca agaagaagta tttctacaag   1080
 ttcttccggg atgagaggag ggccgagcgc gcctaccgct tcgtgaagga gaacgagacg   1140
 ctgttcgcgc tgtgcttcgt gcccttcgtg tgctggatcg tgtgcaccgt gctgcgccag   1200
 cagctggagc tcggtcggga cctgtcgcgc acgtccaaga ccaccacgtc agtgtacctg   1260
 cttttcatca ccagcgttct gagctcggct ccggtagccg acgggccccg gttgcagggc   1320
 gacctgcgca atctgtgccg cctggcccgc gagggcgtcc tcggacgcag ggcgcagttt   1380
 gccgagaagg aactggagca actggagctt cgtggctcca aagtgcagac gctgtttctc   1440
 agcaaaaagg agctgccggg cgtgctggag acagaggtca cctaccagtt catcgaccag   1500
 agcttccagg agttcctcgc ggcactgtcc tacctgctgg aggacggcgg ggtgcccagg   1560
 accgcggctg gcggcgttgg gacactcctg cgtggggacg cccagccgca cagccacttg   1620
 gtgctcacca cgcgcttcct cttcggactg ctgagcgcgg agcggatgcg cgacatcgag   1680
 cgccacttcg gctgcatggt ttcagagcgt gtgaagcagg aggccctgcg gtgggtgcag   1740
 ggacagggac agggctgccc cggagtggca ccagaggtga ccgagggggc caaagggctc   1800
 gaggacaccg aagagccaga ggaggaggag gagggagagg agcccaacta cccactggag   1860
 ttgctgtact gcctgtacga gacgcaggag gacgcgtttg tgcgccaagc cctgtgccgg   1920
 ttcccggagc tggcgctgca gcgagtgcgc ttctgccgca tggacgtggc tgttctgagc   1980
 tactgcgtga ggtgctgccc tgctggacag gcactgcggc tgatcagctg cagattggtt   2040
 gctgcgcagg agaagaagaa gaagagcctg gggaagcggc tccaggccag gcctgggtgg   2100
 cggcagctgg ctggggaccc aactggctcc agaagtaccc tttcgaccac cctgctgtga   2160
 catctgcccc acacctccac cagaccctcg gctcctccag ggcaaggctt ttgccagagt   2220
 tcctttgaat atagctccaa ttcagcccct gcccaggggc ttggcatctg ttgagaggat   2280
 gaatgtcacg gtgttggcag gggctgggcc tggggaccca aagacccatg caatgactga   2340
 cccactgtgc catctgagca gcctcacgct gtcccactgc aaactccctg acgcggtctg   2400
 ccgagacctt tctgaggccc tgagggcagc ccccgcactg acggagctgg gcctcctcca   2460
 caacaggctc agtgaggcag gactgcgtat gctgagtgag ggcctagcct ggccgcagtg   2520
 cagggtgcag acggtcaggg tacagctgcc tgacccccag cgagggctcc agtacctggt   2580
 gggtatgctt cggcagagcc ctgccctgac caccctggat ctcagcggct gccaactgcc   2640
 cgcccccatg gtgacctacc tgtgtgcagt cctgcagcac cagggatgcg gcctgcagac   2700
 cctcagcctc tcgcttcctt ctgacccgac cccgagttct ttctccggac ggtgtcgaga   2760
 acccgggcgc cggctggggc tggagtctcg ctggcctcgg agcgcccccg agccctcggg   2820
 cagacagcga ggcgaggacc caggtggagg cggccggggg cgcgggcgga gggaggaggc   2880
 gcgggaggga acccccggcc cgcgggcccc acccacagcc gccccgggac gcagctcggg   2940
 gtccaggctc gagctttgct cactcagggc gcttcgtgca gggaacgcca ggcccccgga   3000
 cgcgacccac gcggccgctg ccagcgggga ccgaggggag ccggggccgc ggccgcgagt   3060
 ccacgtcccg cccccgggcc cggcccagcg accgcccccg ccgcccaggg accgcccccg   3120
 cctcccagcg accgcccggg ccctcggggc ggggaccgcg gaccttcctg gtggcgcggc   3180
 agccgggcgg ctcctccttc ctcccggccc tggcgtggag cagagggaca caggttccca   3240
 cgctggcgcc cggcgaccgg gtggggctgc ggccgctcag gcccagcagc tccatggagg   3300
 acgccggcga ggaccccacc acgtttgctg cccactctct gcccagtgac ccccgtctct   3360
 tggccactgt gaccaacgca tacctgggca cacgagtgtt tcacgacacg ctgcacgtga   3420
 gcggcgtgta caatggggct ggcggggaca cgcaccgggc catgctgccc agccccctca   3480
 acgtccggct ggaggcccct gcagggatgg gggagcagct gaccgagacc ttcgccctgg   3540
 acaccaacac aggctccttt cttcacaccc tggagggccc ccgcttccgg gcctcccagt   3600
 gcatctatgc gcatcgcacg ctgccccacg tgctggcttt ccgagtgtcc atcgcccgcc   3660
 tggccccggg gagcgggccc atcacgctgc tcctgcggtc agccttctcc ccagaaagcc   3720
 cagacctgga cctgcatcag ggtcctgact tccagggagc ccggtacctg tatggccaca   3780
 ccctcacccc tgagcagccc ggggggccac agcaagaggt acacatgctg tggacaccag   3840
 cacccccaga cctgaccctt ggggaaggtg aggaggctag gacgtgggac ttcctgacag   3900
 cagtgggcgg cagccaggct gaggctcagg cctgcctcac tgaggccctg cagctgcagg   3960
 ccaggggagc tctgtatacg gctcacgcac aggcctgggc ccagctctgg gtagaatgtg   4020
 gcttggacgt ggtggggccc ctgcagctgc gccaggccct gcgtggctcc ctctactacc   4080
 tgctcagtgc cctgccccag cccaaggccc caggatacat ctgccatggc ctcagtcctg   4140
 ggggcctctc caatgggagc cgtgaggaat gctactgggg ccacgtcttc tgggaccagg   4200
 acctctggat gttcccgagt atcctgatgt tccacccaga agccgccagg gccatcctgg   4260
 agtaccgcat ccgcacgctg gacggggccc tggagaacgc ccagaacctg ggctaccagg   4320
 gagccaagtt tgcctgggag agtgcagact ccggcctaga ggtttgccct gaggacattt   4380
 acggagtcca ggaggtccac gtcaacgggg ccgtggtgtt ggccttcgag ctgtactacc   4440
 ataccaccca ggacctgcag ctatttcgag aggctggtgg ctgggacgtg gtcagggctg   4500
 tggccgagtt ttggtgcagt cgtgttgagt ggagccccag ggaggaaaag taccacctga   4560
 ggggagtcat gtcccccgac gagtaccatt caggggtcaa caactctgtg tacaccaacg   4620
 tcctggtcca gaacagcctg cgctttgctg ctgccctggc ccaggacctg ggtcttccca   4680
 tccccagcca gtggctggcg gtggctgaca agatcaaggt accctttgac gtggagcaga   4740
 acttccaccc ggagttcgat gggtatgagc ctgaccctcg agtctgtcct ggaacacctt   4800
 ccagtcagcg gcacctccct gtaggagagg tggtgaagca ggcagacgtc gtgctcctgg   4860
 gatacccagt ccccttctcc ctgagtcctg atgttcgcag gaaaaatctg gagatttacg   4920
 aggctgtgac gtccccccag ggccccgcca tgacctggag catgtttgct gtgggctgga   4980
 tggagctgaa ggacgcagtg cgggcccggg gcctccgtgg acaggagctt tgccaacatg   5040
 gctgaaccct tcaaggtgtg ggacggagaa tgcagacggg tcaggcgctg tgaacttcct   5100
 gacaggcatg gggggcttcc tgcaggcggt ggtcttcggg tgcacggggt tcagggtcac   5160
 ccgagcgggt gtgacctttg accctgtgtg tctgtcgggg atcttcaaaa ggaagcgttt   5220
 ccggattctt caaccagggg aacaagctca acttctcttt ttccaaggac tccgtgaccg   5280
 tggaggttac gagcccgagc agggccctgt gctcctcacc tggaggctga gctgtggcca   5340
 tcccagtccc ggctctccct gttgccagga cacaaggtct cctttccccg ctcggctggc   5400
 cggatacaaa tgtcaccccc gaagctgcct ggaagttcca gctccgagtt ccctgggagg   5460
 actttttcag atgttaggga cccgctccag agccccctct gggtcaccct gggttcctcc   5520
 aagccccacc gaggtcactc actgtggacc ctgcctctga ataatcagga acggtggctt   5580
 cagagacgtc tcttgggcct tccctctggc cacgtctgca cccacccctg nctgggcacc   5640
 ctcctagcct gccatccctc acctgcagcc aggctctcag ggaaggtcca tgctgcttgg   5700
 cctgagttca aggctttctg cctgtagcct gggactcccg tggacccccg tgggcaggtg   5760
 gcttccccgt ggcatctcca caccgcctct gcctgcccct gtggactgat gctatcgcgc   5820
 accgtcccac gaccccaccc cgagctcctg aagccggggt ctgagcctgc atcacctctg   5880
 ggcctcttca tcccccactc tcctgagagc agtggtcaca gcggccggcc gttcttgctg   5940
 agaaggcaga gaggcaggct caggcctcag cgtgggacag cagggataag gggcacgaag   6000
 gacggggact cggccccttc agaattcctc aggactctca ggtgcagctt tgccaaaaag   6060
 gaacttttca tgtcatgnca gttgagggga cttagtctca atccccaggc tcctcttgaa   6120
 ctctgggcaa actttaatca ggttgggcag cctctgctac agcgtggagt gggatggctc   6180
 tcttccctca gccacgcccg ctttgtaagg acagaggtgg gggagtggga agtgggaagt   6240
 cacccagaga acaggagagg gatttgaggg cgagaccccc agcgctctcc acggaccagc   6300
 cagagggact ggagcccagg tgtgcatggg ttcaaggccc tggccctgcc ccagcctctg   6360
 tcttgggagc tcagccccca gggtcggtcg tcagcaagtt tcccaagaac aagatgtgat   6420
 ggcatctgct gctgaaaccc tgatgaggac cagcgccccc tgcaacgctg tcaagcctga   6480
 ggaattaaaa gctttggtgc tgggaagagc attattcctc tgaggagccg ctgtgcttcc   6540
 ttctgaagcg atggccgtgc cccgggtccc atttctcctt tcacttgagt cgggaagcac   6600
 agcaacttta acgtcgcgcc cagcaacatg gctcccctcg caaaaaaa                6648



      <210> 1602
      <211> 885
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(885)
      <223> n = a,t,c or g


      <400> 1602
 tttttgaggg tcaaatatct ttaaataaag tgccaggaac aataaatact gtacaggaag     60
 agagtgcacg tgaacgtcca gatctgtggt ttcaacctcg agactccaag gacctgcaag    120
 gggggtggac aagggacccg ggatcaggga ggctccgggt agacaagagg ggcaggactg    180
 gggttgcaga ggcaagggcc caggtaagtg ggctgaggga tcccagccac agtaggttcc    240
 gtatcttggg atggaaggaa gctaagggct cccccaggga tttggccaaa ctagcctggg    300
 gtgagagcct gggccaaggg tcaagggtca ggatcccaga ggaggggcca gggctggaag    360
 atccaggaag cactggcctg gtttgggagc ctggggttaa aggggagccc gtggaggccc    420
 caggggtgtg gtgacccagg ggctcacgag tagctctgat gctgttggcg ccggcgggca    480
 gagcgcatct tctcgaaccg ggcctccatc tcctccagca ctcgcggtgt gtaacggaca    540
 accagcttca ccgagccctg ggccgccttc agcagctcca ccgccttctc atgctgctca    600
 ccctcaacgc tcacaccgtt caccgacaac agttgatccc cacgcttgag gcctccatgg    660
 cggtcagcca caccccctgg gatgacccgg gagatgtaga tgggcgagtt ttgctctttg    720
 ccacccatga tgttgaagcc taggccctca tccgtcttgg gtagctccac taccctggga    780
 tgtgcgtggc cctcgctggc tgtgaaggca gccactgtgg cctttgctgt ggcatgggct    840
 cggatctcgc tcgtgccgaa tctgcagcga attccttntt ccaca                    885



      <210> 1603
      <211> 474
      <212> DNA
      <213> Homo sapiens


      <400> 1603
 tttgagttca gtacactagg ccgtgcggtg gaattctgtc tggctagtcc tgtctagcgc     60
 gcccatttcg agcccaagtt tccagctcgg gtttccgggc tcagaatttt ccaggagtgg    120
 gttcttgggc agtggctgtg ggagcaggaa tggcgcagct agagggttac tgtttctcgg    180
 ccgccttgag ctgtaccttt ttagtatcct gcctcctctt ctccgccttc agccgggcgc    240
 tgcgagagcc cctacatgga cgagatcttc cacctgcctc aggcgcagcg ctactgtgag    300
 ggccatttct ccctttccca gtgggatccc atgattacta cattacctgg cttgtacctg    360
 gtgtcagttg gagtggtcaa acctgccatt tggatctttg gatggtctga acatgttgtc    420
 tgctccattg ggatgctcag atttgttaat cttctcttca gtgttggcaa cttc          474



      <210> 1604
      <211> 3139
      <212> DNA
      <213> Homo sapiens


      <400> 1604
 ttttttggag cgaggataca gaagatttat tcgaagtcca ggtacagact ggccaacctg     60
 cctctacagc gtccacagcg aacacagggc tagacaaggg aggagtttct caaacggttt    120
 taatcggttc tctccgcgtc acaagccatc gggtaaggca acggaatgtg cgtggggtcc    180
 cctgtggctc cgcggtcaca atactgagcc tggaattgct gttagcaaaa tatacatttg    240
 tgtcaccata aaaaaccgcg ccgccgcccc tcgggtctca caacaggtat aaaaaattat    300
 aaatatttac acccttgtta cacgctttta cggaaagggg atcctaggag agcccccggg    360
 acaggacgcg ggggcggtag aaagagcaca gagaagacag gaggagcgcc cgccttccgg    420
 gtcccagcat cagaggcagg caaaacacag aaatgagact ttggtccaaa atttgaagga    480
 agaaaaaacc ctgaagtttg agagcaagtt ttctaggcga ctgcaggtga aggcgtggtg    540
 taaggcaacc ggaggcgatg ccagaggcgg cgacacgccc gccccttccc tgaagctcag    600
 gggctctaag ataggaccgg ggctccctgt gcctgaccca ctgggcggcc ccgcctgctc    660
 tctggaaact gggtcctgcc tgtgacttaa ttacaaggaa taaaataaaa gtaacagcat    720
 acaaggtaat accacaagga agtttagatt acactcatac cattgtatca tcttgctata    780
 aaaagttact taaaactatt tcttttgcat ataaatgaaa aaagattaga atatttggtc    840
 aactggaaat attgctaggc acagacgtct gcaactgcaa agtatataat acagagatta    900
 tgtcgaccag ctccgcagct ggagcagcgg ggagcccgcc tgggggcaga agggaaggcc    960
 ctgggggcgg ggtgaaggga gaatcacgtg acttgattag agggctgggg ttggggtgtc   1020
 gcagccgcgg ccgccgcgcc ccagctgcat gatcctgcag gagccggcca ggccccctgc   1080
 ctctctctgg tgtgaccccc tcaccccttg ggtccccagg acaccccggg tgggtgtgtg   1140
 gctgcaggaa ggcaggtttt ttaaggcaca aggaagccaa gtcgtggtcg gggcgcccac   1200
 ctgcaggccc cacgcccgac acaggcccca ccaaggcatg gccccgaggg tctggccccg   1260
 ggtgtggagg gccgggaact cccgctgcca cagtcaccaa gagcctgagc tgtccctgtc   1320
 accgcagggt gagcaaggtg aactagattt aattttttta aaaacaggta aactgatttc   1380
 tctttaaaaa aataaaatct ctggtctgct aaggtcactt cagctgtttt taaagtggct   1440
 tttctctgga atgatggaag ttgtcgccag ggggcccggc cgtgggggcc tgtgccccta   1500
 gatggtggac ttggagaagg agacccgcag gtggtggttc tccccgaggt cgtggttgtg   1560
 caggtcaatg agggcctgga ccgcctcctc cacggagccc atctggatca gtgccatctt   1620
 gcggtccttc tggaagaact tgaatccttt gacgacgccc ccattgctgg aaaacaggac   1680
 cttgagatcc tcctcggaga ctgagggcgg gatgttggag aggtgcagcg tggccgaggg   1740
 cgggaatatg ttctggaagt tcttggagcc cggcttcttg aagcggtgca ggggtgagtt   1800
 gccgtagtcc ttggtcaggc cctggtcctc ctggccctcg cggggcagct gcacgttctg   1860
 gtgcttcgag agcgtgatgc ggatgggctt cccgtgcagc ttgtgcccgt tcaggtggct   1920
 catggccagc tgggcctggt tgccgtccgc catctgcact agggcgttct ccttcttatt   1980
 gaacaggatc ttcacgcgct gcacgtcacc gtagacgccg aaaagaataa agaggctttg   2040
 gggtgtgact ctctctgggt tgaggttgct gaccagcaat acagaatttc ctgcccccgc   2100
 caggcccggg atggcgatcc gacctgccgc cgcagctgcc gccgccgccg aggggatggc   2160
 caggggggcc agggcgccgt ggacgttcgg aacggaaagg ccgaaggccg cggccatggt   2220
 ctggtccagc gagggctggc tgtccccgga aggcaggtct gggcgtgtgt agtcacggct   2280
 cttgtcattg ttgtacttga cgttgaggct ggtgagcttg gaaaagtcga tgcgcagcgt   2340
 gcagcaggcg ttgtagatgt tctgcccgtc cagcgacagc ttggcgtgct gggcgctcac   2400
 ggggtccgca tactgcagca gggcctggaa ctggttgttc ttggtgaagg tgatgatctt   2460
 caacactgtg ccgaacttgg agaaaatctg gtgcagcaca tccagggtca cagggtagaa   2520
 gaggttctcc acgatgatcc tgagcacggg gctctgcccg gccatcgcca tccctgcatc   2580
 cacggccgcc gccgaggcag ccaaggccag gttccccgac tggaccgagt tcaccgcctg   2640
 cagggccgcc tgggcccgcg cctggttggg agagctgtcg gtcttcagct ccttgtggtt   2700
 ggagaactgg atgtagatgg gctggccgcg cagcacaggg gtcaccgagg tgtagtagtt   2760
 caccatggta ttggcagcct cctccgtgtt catctcgatg aaggcctggt ttttcccctt   2820
 cagcatcagg aggttggtga ccttcccaaa gggcagcccc agggagatga cttccccctc   2880
 cgtgacgtcg atggggagct tccggatgtg gatcactcta gaggggacgc ctgcacttcg   2940
 gctgtcacct ttgaacttct tgctgtcatt tccgtttgct gcagaagccg agttgctgct   3000
 catgataaac ggtccgttag tgacacaagt agagaaaagc tcgtcagatc cccgctttgt   3060
 accaacggct atatctggga caatgccgtc catggcacac agagcagacc cgcgggggac   3120
 ggagtggagc cgccggaat                                                3139



      <210> 1605
      <211> 2238
      <212> DNA
      <213> Homo sapiens


      <400> 1605
 tttttttttt ttgatgattt ggatattatt attacaaaga atttaaatat acaagtttgg     60
 ctatgaaaga cccagctaag ccacttaggc aaaagtctat ctttgatgtc atagtttcca    120
 agaagtatca taagagtcaa acagttaaac atttctctgt gctttttttt tctattttct    180
 aggaaatgtt gggtttagag agaagctcat caacttactt atacaaatca ggatatactg    240
 aggggggggg aggataaact cgacatttcc atattttata atataatgtg gaaagattca    300
 gaaatgactg agaagataca gtgatatgat atttaaagca aatattggca tatgcttata    360
 caagaaaggc atcttacaat aatatttctg ttggtacatt acaatttttc agctagtaat    420
 tctaaaatgc cagaggtcct atgatgcaat atcaaaaaaa ccagggaact gacatacaaa    480
 gtcaaatata aagatagtaa cattcagtca tccacagata aaaggctatc tggacataag    540
 cctgaaacaa gcaagacgcc atccactgcg atttcgccgg ttttgccctt gccacgttct    600
 gcttcaaaaa tgatgctttt ggtagcatca gttccttgat acaactgaat tttccctgtc    660
 ttccactttt catcctcact cgtggtcttc tcccatgcca gggcattgtt actgtttttc    720
 acaaacactc gaagtttccc gactttgtct ccggccagcc ggtaatcaaa gagcaaacag    780
 aagttgcttt ggggttgcag gtcaggtagg agaagtttca atcggccaat gtctttcctt    840
 gtgaccctgc caaaggccgg gaactgccaa tatagaagcc aaatagcatt atctccgatc    900
 agcaggattc ccagtcaaaa tcatcttcgt ctatcctgtt tcccagtcac agatccccat    960
 gattgaagct gcagtcaacc gagatattta aatctgcttt atgttccagt ttggaagtta   1020
 gcgctttcct ttggaccgag aatcaggccg aattcacctg cttcattcac cttagggaaa   1080
 aacacatctc cctcgaaaag gtcgctccct cctatgtcaa tccttcaggg ctttctcttc   1140
 tcttttctca tcctcaagcc cctctttcat tttctcttca ttcccttttt taccctccat   1200
 gagagttccc gcctctggaa actatctctt catagttgaa gggctgcaag ttcaccttag   1260
 gggtaggagt cctggtgggt tctggggtaa catttttaat ttttgccttc tttttcatgc   1320
 tgtttttgtg agcaagcaac ttcttgattc tgtctttgat ggtaccaggt gctctgagga   1380
 cttccttcac agaattttca gggatagcag aacaccgaag tccattgcct ttatatccct   1440
 gcttgcattt acacttgaag gacccttggg tattgaagca attggcatgg tggctgcacg   1500
 tatggctatc catagtacat tcatttatat ctatacagtc atatcgtcca ctgatatatt   1560
 gcagttcgaa accaatgtga catttgcagt agtagcttcc aaatgtgttc acacatcttc   1620
 gattgtaggg acagatgact ttaccagagg cacattcatc aatatctaga cagtctcttc   1680
 catttggggc caggcggagt cctgaggatg gacacaggca ctgtggccct tcttctgtgt   1740
 cttcacagct gtactgacag tttatcatgg cacatgtcct agagttcaca cacgtagcat   1800
 ctggcatgag catgtggcca ctgaggcaaa agcacttgta gcttccgtgt gtattcacac   1860
 atctgtgttg gcatggccgg ggtttcattc cacactcatt cacatcttga ctgcaggttt   1920
 tcccggtgta tcctggaaag catctgcatt tgtttggtcc cacgcactca ccaaacttac   1980
 atccaggttc gcatgtagct tcacagactc ccttgctgtt tcttctccag ccgtagcagc   2040
 aggccagttt agttccatag tgacagaccc caggctgacg tgccgatgct aacaacccgt   2100
 gatgccttgc actggccgcg ttcccgaaac cacctgccac ccaggagagc agcagcggga   2160
 gcgcaaggct ccagggcaga ggcattctcg cacgggtcct ccttcctcct cctgagcccc   2220
 cctcgggagg gcgccggc                                                 2238



      <210> 1606
      <211> 2238
      <212> DNA
      <213> Homo sapiens


      <400> 1606
 tttttttttt ttgatgattt ggatattatt attacaaaga atttaaatat acaagtttgg     60
 ctatgaaaga cccagctaag ccacttaggc aaaagtctat ctttgatgtc atagtttcca    120
 agaagtatca taagagtcaa acagttaaac atttctctgt gctttttttt tctattttct    180
 aggaaatgtt gggtttagag agaagctcat caacttactt atacaaatca ggatatactg    240
 aggggggggg aggataaact cgacatttcc atattttata atataatgtg gaaagattca    300
 gaaatgactg agaagataca gtgatatgat atttaaagca aatattggca tatgcttata    360
 caagaaaggc atcttacaat aatatttctg ttggtacatt acaatttttc agctagtaat    420
 tctaaaatgc cagaggtcct atgatgcaat atcaaaaaaa ccagggaact gacatacaaa    480
 gtcaaatata aagatagtaa cattcagtca tccacagata aaaggctatc tggacataag    540
 cctgaaacaa gcaagacgcc atccactgcg atttcgccgg ttttgccctt gccacgttct    600
 gcttcaaaaa tgatgctttt ggtagcatca gttccttgat acaactgaat tttccctgtc    660
 ttccactttt catcctcact cgtggtcttc tcccatgcca gggcattgtt actgtttttc    720
 acaaacactc gaagtttccc gactttgtct ccggccagcc ggtaatcaaa gagcaaacag    780
 aagttgcttt ggggttgcag gtcaggtagg agaagtttca atcggccaat gtctttcctt    840
 gtgaccctgc caaaggccgg gaactgccaa tatagaagcc aaatagcatt atctccgatc    900
 agcaggattc ccagtcaaaa tcatcttcgt ctatcctgtt tcccagtcac agatccccat    960
 gattgaagct gcagtcaacc gagatattta aatctgcttt atgttccagt ttggaagtta   1020
 gcgctttcct ttggaccgag aatcaggccg aattcacctg cttcattcac cttagggaaa   1080
 aacacatctc cctcgaaaag gtcgctccct cctatgtcaa tccttcaggg ctttctcttc   1140
 tcttttctca tcctcaagcc cctctttcat tttctcttca ttcccttttt taccctccat   1200
 gagagttccc gcctctggaa actatctctt catagttgaa gggctgcaag ttcaccttag   1260
 gggtaggagt cctggtgggt tctggggtaa catttttaat ttttgccttc tttttcatgc   1320
 tgtttttgtg agcaagcaac ttcttgattc tgtctttgat ggtaccaggt gctctgagga   1380
 cttccttcac agaattttca gggatagcag aacaccgaag tccattgcct ttatatccct   1440
 gcttgcattt acacttgaag gacccttggg tattgaagca attggcatgg tggctgcacg   1500
 tatggctatc catagtacat tcatttatat ctatacagtc atatcgtcca ctgatatatt   1560
 gcagttcgaa accaatgtga catttgcagt agtagcttcc aaatgtgttc acacatcttc   1620
 gattgtaggg acagatgact ttaccagagg cacattcatc aatatctaga cagtctcttc   1680
 catttggggc caggcggagt cctgaggatg gacacaggca ctgtggccct tcttctgtgt   1740
 cttcacagct gtactgacag tttatcatgg cacatgtcct agagttcaca cacgtagcat   1800
 ctggcatgag catgtggcca ctgaggcaaa agcacttgta gcttccgtgt gtattcacac   1860
 atctgtgttg gcatggccgg ggtttcattc cacactcatt cacatcttga ctgcaggttt   1920
 tcccggtgta tcctggaaag catctgcatt tgtttggtcc cacgcactca ccaaacttac   1980
 atccaggttc gcatgtagct tcacagactc ccttgctgtt tcttctccag ccgtagcagc   2040
 aggccagttt agttccatag tgacagaccc caggctgacg tgccgatgct aacaacccgt   2100
 gatgccttgc actggccgcg ttcccgaaac cacctgccac ccaggagagc agcagcggga   2160
 gcgcaaggct ccagggcaga ggcattctcg cacgggtcct ccttcctcct cctgagcccc   2220
 cctcgggagg gcgccggc                                                 2238



      <210> 1607
      <211> 2841
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2841)
      <223> n = a,t,c or g


      <400> 1607
 ttttaattgt ttttcttttt cttttttttt ttttaataag ttaaagttaa tacaaatata     60
 aaaaggggaa agtcctctag attcaatgac atccacaaat tgtacattat ttacaccaaa    120
 agcacagggc tcgtgtgggt gaacagtctg cagtcaaagc cgatgctggg tgtccctgta    180
 gtgtagcagc ccccgcgccg ggggctcagg cctcaactga gggttttggt catttttcaa    240
 gtctgaaaag tgggctgttc tccttgcctt tgttgtttct tcttttcctg gccgtctggg    300
 ttttttctcc acaatggggt ggggtgggtt tgtgtccccg attcacttgc tagtccccag    360
 aaagggtgtc ccagcccgag actcctttcc gggaaggagg ctccttccgt gctgggtact    420
 gggtggttgt gatcggaacg tgttcgatcc cctcttctca tcactgctgc tccaactgga    480
 tttattactc ccgggaatgg tcagagcctt ggttggagcc taagagaatg gaggagggcg    540
 tctctctgga gccagaaagg tcaagggtcg agccactctc cttgcttttc tcagctgacg    600
 tctccttctc tttggaaggc gctggccgtt tctgaaggtg ctgattgtgt gctcgaggag    660
 ctcccctggg aggacttatt tagtgtttct gtgttcacct tcagcatccg cttcctgctt    720
 gaggagcagt agctgactgg gtgcaggact tcaatgtgct caggccagtg ggcttgcttg    780
 gcaggggtag tcacagtagc tggtgttcca acagcagtaa aagatggcct ccttcttgaa    840
 gttggcgcac cactgcttct tcttggtctc atccaccgcc tgctgcttct ccaactccag    900
 ctgcttcttc acctcggcga tgagccggtc ccgctcctgc tcccagctct gccgcatctc    960
 cgccatggtc agctctaagt tgtgtttcat ttcggagaag ctcttgctgg tgcagccact   1020
 ggagcttctc tatctcgatc ctcaagcctt gcgaatcttc agctaattgt gctttccaag   1080
 tagtggtttt tagaaagatc gttgtatatt tctgtccatt gtacctttta ttgcatccat   1140
 ccaatttgct agtgtacttg gcaatatcag cggcgacatc agctgaggca gtgccgatgg   1200
 gcaggtcacc gttgactgag gacacaaggg tgctcatgga ccccgagctg gtgaccaggg   1260
 gcgatgactg tgtgctggtc accagggtga tggtggacgt ggatgggctc tgtgtgatct   1320
 ccttctgctg gacagttgat gaagttccac acgaccgctg cacggccggg gcagtcctcc   1380
 ttcggtaaaa gcggcctctg ctttttcact gggcttcctg tggcggcggg ggccggggcc   1440
 gtgacggtga ccgtggagga cgtgctggtg gtggctgtgg cgccagccgc ggaagtttgg   1500
 gcggaagagc gggtgagcac cggtgtttcc gggggagaat ggctgcccac cgtcgtggat   1560
 ggtggtgttt tacctacaac atcctgtttg ggagatggtt ctttgggttc cttcttattt   1620
 tttcgaccct cccgcccaga atggtcttct cctaaatcta tgacaagttc gttcctctga   1680
 atcagagtcc aggcccaaat gaactgtggg ggaatccgtc tcatcttttc ccttcagttt   1740
 atccttaatg gggtgaggtg aaggttttgc ctttccggaa aagtccttct caggctcagg   1800
 gctggccttg tccttgactg ctccagggtc tgccttctcg ctggctggtg acgtgctttt   1860
 cagctcctct ttaatctcca ctgggtttgt aggcttgggc ttttttttaa cagcagatgg   1920
 ctctttgtcc atctgacaac cttctttgtc ctctgtgtct tcctggctcg ttccttaaga   1980
 cttctgctca tcatcactga tatactcact atcgctacta tctgacttct cagaatcctc   2040
 cgaatcgctg tgctctacgg ccgtatagac atcttccgag atttcattta tgcctaattg   2100
 tgctttgcaa ctctctatgg tcttgtcaag attcagctgg aacctgctac gaatctggcg   2160
 cttgggagag atgagaggaa caggggtgga ctgttgctgg accgactcgc tcagctcctt   2220
 caaatccatc tcagctttgc ttcgatccag gttaagattc aggatgctgc cggtggtgga   2280
 ggttttgtcc gttttcgtcg tgataggagc tgacagttga ggagagaagg gctttgggct   2340
 gccggataaa ctccctgctt gtcccgtctt ggtggaggct ggtgaagctg tgctcttatc   2400
 caggaagtcc atggactcct cgctcgcact gaagtggctc gacgtggcct tcttctcagc   2460
 atcctgctcc acgtcggagc ccgtgtgcac agaagagttt gtgctcatgg gggagcgcgg   2520
 catatccgac aaggaaatcc ggcggcctgt gcccccactc agcacaggct tgctcatcag   2580
 gatcttgggg gatgccgtca tgtcaaagtt gagcttgacc ttctcctgct tgtctatctt   2640
 ggcagtgccg gcgctggggt tggtgggatc gagcagcatt tgatactggc tgttgggtgt   2700
 gtagggtgtc ctaaatggag agtaattaaa aaccccaaac ttcctgcgga tgttctccac   2760
 gtaaacctcc atctcttgca tggcactgtt gaagatgctc ttagtctttt tcacanaaaa   2820
 aggaatttct ttagacatga g                                             2841



      <210> 1608
      <211> 2841
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2841)
      <223> n = a,t,c or g


      <400> 1608
 ttttaattgt ttttcttttt cttttttttt ttttaataag ttaaagttaa tacaaatata     60
 aaaaggggaa agtcctctag attcaatgac atccacaaat tgtacattat ttacaccaaa    120
 agcacagggc tcgtgtgggt gaacagtctg cagtcaaagc cgatgctggg tgtccctgta    180
 gtgtagcagc ccccgcgccg ggggctcagg cctcaactga gggttttggt catttttcaa    240
 gtctgaaaag tgggctgttc tccttgcctt tgttgtttct tcttttcctg gccgtctggg    300
 ttttttctcc acaatggggt ggggtgggtt tgtgtccccg attcacttgc tagtccccag    360
 aaagggtgtc ccagcccgag actcctttcc gggaaggagg ctccttccgt gctgggtact    420
 gggtggttgt gatcggaacg tgttcgatcc cctcttctca tcactgctgc tccaactgga    480
 tttattactc ccgggaatgg tcagagcctt ggttggagcc taagagaatg gaggagggcg    540
 tctctctgga gccagaaagg tcaagggtcg agccactctc cttgcttttc tcagctgacg    600
 tctccttctc tttggaaggc gctggccgtt tctgaaggtg ctgattgtgt gctcgaggag    660
 ctcccctggg aggacttatt tagtgtttct gtgttcacct tcagcatccg cttcctgctt    720
 gaggagcagt agctgactgg gtgcaggact tcaatgtgct caggccagtg ggcttgcttg    780
 gcaggggtag tcacagtagc tggtgttcca acagcagtaa aagatggcct ccttcttgaa    840
 gttggcgcac cactgcttct tcttggtctc atccaccgcc tgctgcttct ccaactccag    900
 ctgcttcttc acctcggcga tgagccggtc ccgctcctgc tcccagctct gccgcatctc    960
 cgccatggtc agctctaagt tgtgtttcat ttcggagaag ctcttgctgg tgcagccact   1020
 ggagcttctc tatctcgatc ctcaagcctt gcgaatcttc agctaattgt gctttccaag   1080
 tagtggtttt tagaaagatc gttgtatatt tctgtccatt gtacctttta ttgcatccat   1140
 ccaatttgct agtgtacttg gcaatatcag cggcgacatc agctgaggca gtgccgatgg   1200
 gcaggtcacc gttgactgag gacacaaggg tgctcatgga ccccgagctg gtgaccaggg   1260
 gcgatgactg tgtgctggtc accagggtga tggtggacgt ggatgggctc tgtgtgatct   1320
 ccttctgctg gacagttgat gaagttccac acgaccgctg cacggccggg gcagtcctcc   1380
 ttcggtaaaa gcggcctctg ctttttcact gggcttcctg tggcggcggg ggccggggcc   1440
 gtgacggtga ccgtggagga cgtgctggtg gtggctgtgg cgccagccgc ggaagtttgg   1500
 gcggaagagc gggtgagcac cggtgtttcc gggggagaat ggctgcccac cgtcgtggat   1560
 ggtggtgttt tacctacaac atcctgtttg ggagatggtt ctttgggttc cttcttattt   1620
 tttcgaccct cccgcccaga atggtcttct cctaaatcta tgacaagttc gttcctctga   1680
 atcagagtcc aggcccaaat gaactgtggg ggaatccgtc tcatcttttc ccttcagttt   1740
 atccttaatg gggtgaggtg aaggttttgc ctttccggaa aagtccttct caggctcagg   1800
 gctggccttg tccttgactg ctccagggtc tgccttctcg ctggctggtg acgtgctttt   1860
 cagctcctct ttaatctcca ctgggtttgt aggcttgggc ttttttttaa cagcagatgg   1920
 ctctttgtcc atctgacaac cttctttgtc ctctgtgtct tcctggctcg ttccttaaga   1980
 cttctgctca tcatcactga tatactcact atcgctacta tctgacttct cagaatcctc   2040
 cgaatcgctg tgctctacgg ccgtatagac atcttccgag atttcattta tgcctaattg   2100
 tgctttgcaa ctctctatgg tcttgtcaag attcagctgg aacctgctac gaatctggcg   2160
 cttgggagag atgagaggaa caggggtgga ctgttgctgg accgactcgc tcagctcctt   2220
 caaatccatc tcagctttgc ttcgatccag gttaagattc aggatgctgc cggtggtgga   2280
 ggttttgtcc gttttcgtcg tgataggagc tgacagttga ggagagaagg gctttgggct   2340
 gccggataaa ctccctgctt gtcccgtctt ggtggaggct ggtgaagctg tgctcttatc   2400
 caggaagtcc atggactcct cgctcgcact gaagtggctc gacgtggcct tcttctcagc   2460
 atcctgctcc acgtcggagc ccgtgtgcac agaagagttt gtgctcatgg gggagcgcgg   2520
 catatccgac aaggaaatcc ggcggcctgt gcccccactc agcacaggct tgctcatcag   2580
 gatcttgggg gatgccgtca tgtcaaagtt gagcttgacc ttctcctgct tgtctatctt   2640
 ggcagtgccg gcgctggggt tggtgggatc gagcagcatt tgatactggc tgttgggtgt   2700
 gtagggtgtc ctaaatggag agtaattaaa aaccccaaac ttcctgcgga tgttctccac   2760
 gtaaacctcc atctcttgca tggcactgtt gaagatgctc ttagtctttt tcacanaaaa   2820
 aggaatttct ttagacatga g                                             2841



      <210> 1609
      <211> 2841
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2841)
      <223> n = a,t,c or g


      <400> 1609
 ttttaattgt ttttcttttt cttttttttt ttttaataag ttaaagttaa tacaaatata     60
 aaaaggggaa agtcctctag attcaatgac atccacaaat tgtacattat ttacaccaaa    120
 agcacagggc tcgtgtgggt gaacagtctg cagtcaaagc cgatgctggg tgtccctgta    180
 gtgtagcagc ccccgcgccg ggggctcagg cctcaactga gggttttggt catttttcaa    240
 gtctgaaaag tgggctgttc tccttgcctt tgttgtttct tcttttcctg gccgtctggg    300
 ttttttctcc acaatggggt ggggtgggtt tgtgtccccg attcacttgc tagtccccag    360
 aaagggtgtc ccagcccgag actcctttcc gggaaggagg ctccttccgt gctgggtact    420
 gggtggttgt gatcggaacg tgttcgatcc cctcttctca tcactgctgc tccaactgga    480
 tttattactc ccgggaatgg tcagagcctt ggttggagcc taagagaatg gaggagggcg    540
 tctctctgga gccagaaagg tcaagggtcg agccactctc cttgcttttc tcagctgacg    600
 tctccttctc tttggaaggc gctggccgtt tctgaaggtg ctgattgtgt gctcgaggag    660
 ctcccctggg aggacttatt tagtgtttct gtgttcacct tcagcatccg cttcctgctt    720
 gaggagcagt agctgactgg gtgcaggact tcaatgtgct caggccagtg ggcttgcttg    780
 gcaggggtag tcacagtagc tggtgttcca acagcagtaa aagatggcct ccttcttgaa    840
 gttggcgcac cactgcttct tcttggtctc atccaccgcc tgctgcttct ccaactccag    900
 ctgcttcttc acctcggcga tgagccggtc ccgctcctgc tcccagctct gccgcatctc    960
 cgccatggtc agctctaagt tgtgtttcat ttcggagaag ctcttgctgg tgcagccact   1020
 ggagcttctc tatctcgatc ctcaagcctt gcgaatcttc agctaattgt gctttccaag   1080
 tagtggtttt tagaaagatc gttgtatatt tctgtccatt gtacctttta ttgcatccat   1140
 ccaatttgct agtgtacttg gcaatatcag cggcgacatc agctgaggca gtgccgatgg   1200
 gcaggtcacc gttgactgag gacacaaggg tgctcatgga ccccgagctg gtgaccaggg   1260
 gcgatgactg tgtgctggtc accagggtga tggtggacgt ggatgggctc tgtgtgatct   1320
 ccttctgctg gacagttgat gaagttccac acgaccgctg cacggccggg gcagtcctcc   1380
 ttcggtaaaa gcggcctctg ctttttcact gggcttcctg tggcggcggg ggccggggcc   1440
 gtgacggtga ccgtggagga cgtgctggtg gtggctgtgg cgccagccgc ggaagtttgg   1500
 gcggaagagc gggtgagcac cggtgtttcc gggggagaat ggctgcccac cgtcgtggat   1560
 ggtggtgttt tacctacaac atcctgtttg ggagatggtt ctttgggttc cttcttattt   1620
 tttcgaccct cccgcccaga atggtcttct cctaaatcta tgacaagttc gttcctctga   1680
 atcagagtcc aggcccaaat gaactgtggg ggaatccgtc tcatcttttc ccttcagttt   1740
 atccttaatg gggtgaggtg aaggttttgc ctttccggaa aagtccttct caggctcagg   1800
 gctggccttg tccttgactg ctccagggtc tgccttctcg ctggctggtg acgtgctttt   1860
 cagctcctct ttaatctcca ctgggtttgt aggcttgggc ttttttttaa cagcagatgg   1920
 ctctttgtcc atctgacaac cttctttgtc ctctgtgtct tcctggctcg ttccttaaga   1980
 cttctgctca tcatcactga tatactcact atcgctacta tctgacttct cagaatcctc   2040
 cgaatcgctg tgctctacgg ccgtatagac atcttccgag atttcattta tgcctaattg   2100
 tgctttgcaa ctctctatgg tcttgtcaag attcagctgg aacctgctac gaatctggcg   2160
 cttgggagag atgagaggaa caggggtgga ctgttgctgg accgactcgc tcagctcctt   2220
 caaatccatc tcagctttgc ttcgatccag gttaagattc aggatgctgc cggtggtgga   2280
 ggttttgtcc gttttcgtcg tgataggagc tgacagttga ggagagaagg gctttgggct   2340
 gccggataaa ctccctgctt gtcccgtctt ggtggaggct ggtgaagctg tgctcttatc   2400
 caggaagtcc atggactcct cgctcgcact gaagtggctc gacgtggcct tcttctcagc   2460
 atcctgctcc acgtcggagc ccgtgtgcac agaagagttt gtgctcatgg gggagcgcgg   2520
 catatccgac aaggaaatcc ggcggcctgt gcccccactc agcacaggct tgctcatcag   2580
 gatcttgggg gatgccgtca tgtcaaagtt gagcttgacc ttctcctgct tgtctatctt   2640
 ggcagtgccg gcgctggggt tggtgggatc gagcagcatt tgatactggc tgttgggtgt   2700
 gtagggtgtc ctaaatggag agtaattaaa aaccccaaac ttcctgcgga tgttctccac   2760
 gtaaacctcc atctcttgca tggcactgtt gaagatgctc ttagtctttt tcacanaaaa   2820
 aggaatttct ttagacatga g                                             2841



      <210> 1610
      <211> 2841
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2841)
      <223> n = a,t,c or g


      <400> 1610
 ttttaattgt ttttcttttt cttttttttt ttttaataag ttaaagttaa tacaaatata     60
 aaaaggggaa agtcctctag attcaatgac atccacaaat tgtacattat ttacaccaaa    120
 agcacagggc tcgtgtgggt gaacagtctg cagtcaaagc cgatgctggg tgtccctgta    180
 gtgtagcagc ccccgcgccg ggggctcagg cctcaactga gggttttggt catttttcaa    240
 gtctgaaaag tgggctgttc tccttgcctt tgttgtttct tcttttcctg gccgtctggg    300
 ttttttctcc acaatggggt ggggtgggtt tgtgtccccg attcacttgc tagtccccag    360
 aaagggtgtc ccagcccgag actcctttcc gggaaggagg ctccttccgt gctgggtact    420
 gggtggttgt gatcggaacg tgttcgatcc cctcttctca tcactgctgc tccaactgga    480
 tttattactc ccgggaatgg tcagagcctt ggttggagcc taagagaatg gaggagggcg    540
 tctctctgga gccagaaagg tcaagggtcg agccactctc cttgcttttc tcagctgacg    600
 tctccttctc tttggaaggc gctggccgtt tctgaaggtg ctgattgtgt gctcgaggag    660
 ctcccctggg aggacttatt tagtgtttct gtgttcacct tcagcatccg cttcctgctt    720
 gaggagcagt agctgactgg gtgcaggact tcaatgtgct caggccagtg ggcttgcttg    780
 gcaggggtag tcacagtagc tggtgttcca acagcagtaa aagatggcct ccttcttgaa    840
 gttggcgcac cactgcttct tcttggtctc atccaccgcc tgctgcttct ccaactccag    900
 ctgcttcttc acctcggcga tgagccggtc ccgctcctgc tcccagctct gccgcatctc    960
 cgccatggtc agctctaagt tgtgtttcat ttcggagaag ctcttgctgg tgcagccact   1020
 ggagcttctc tatctcgatc ctcaagcctt gcgaatcttc agctaattgt gctttccaag   1080
 tagtggtttt tagaaagatc gttgtatatt tctgtccatt gtacctttta ttgcatccat   1140
 ccaatttgct agtgtacttg gcaatatcag cggcgacatc agctgaggca gtgccgatgg   1200
 gcaggtcacc gttgactgag gacacaaggg tgctcatgga ccccgagctg gtgaccaggg   1260
 gcgatgactg tgtgctggtc accagggtga tggtggacgt ggatgggctc tgtgtgatct   1320
 ccttctgctg gacagttgat gaagttccac acgaccgctg cacggccggg gcagtcctcc   1380
 ttcggtaaaa gcggcctctg ctttttcact gggcttcctg tggcggcggg ggccggggcc   1440
 gtgacggtga ccgtggagga cgtgctggtg gtggctgtgg cgccagccgc ggaagtttgg   1500
 gcggaagagc gggtgagcac cggtgtttcc gggggagaat ggctgcccac cgtcgtggat   1560
 ggtggtgttt tacctacaac atcctgtttg ggagatggtt ctttgggttc cttcttattt   1620
 tttcgaccct cccgcccaga atggtcttct cctaaatcta tgacaagttc gttcctctga   1680
 atcagagtcc aggcccaaat gaactgtggg ggaatccgtc tcatcttttc ccttcagttt   1740
 atccttaatg gggtgaggtg aaggttttgc ctttccggaa aagtccttct caggctcagg   1800
 gctggccttg tccttgactg ctccagggtc tgccttctcg ctggctggtg acgtgctttt   1860
 cagctcctct ttaatctcca ctgggtttgt aggcttgggc ttttttttaa cagcagatgg   1920
 ctctttgtcc atctgacaac cttctttgtc ctctgtgtct tcctggctcg ttccttaaga   1980
 cttctgctca tcatcactga tatactcact atcgctacta tctgacttct cagaatcctc   2040
 cgaatcgctg tgctctacgg ccgtatagac atcttccgag atttcattta tgcctaattg   2100
 tgctttgcaa ctctctatgg tcttgtcaag attcagctgg aacctgctac gaatctggcg   2160
 cttgggagag atgagaggaa caggggtgga ctgttgctgg accgactcgc tcagctcctt   2220
 caaatccatc tcagctttgc ttcgatccag gttaagattc aggatgctgc cggtggtgga   2280
 ggttttgtcc gttttcgtcg tgataggagc tgacagttga ggagagaagg gctttgggct   2340
 gccggataaa ctccctgctt gtcccgtctt ggtggaggct ggtgaagctg tgctcttatc   2400
 caggaagtcc atggactcct cgctcgcact gaagtggctc gacgtggcct tcttctcagc   2460
 atcctgctcc acgtcggagc ccgtgtgcac agaagagttt gtgctcatgg gggagcgcgg   2520
 catatccgac aaggaaatcc ggcggcctgt gcccccactc agcacaggct tgctcatcag   2580
 gatcttgggg gatgccgtca tgtcaaagtt gagcttgacc ttctcctgct tgtctatctt   2640
 ggcagtgccg gcgctggggt tggtgggatc gagcagcatt tgatactggc tgttgggtgt   2700
 gtagggtgtc ctaaatggag agtaattaaa aaccccaaac ttcctgcgga tgttctccac   2760
 gtaaacctcc atctcttgca tggcactgtt gaagatgctc ttagtctttt tcacanaaaa   2820
 aggaatttct ttagacatga g                                             2841



      <210> 1611
      <211> 929
      <212> DNA
      <213> Homo sapiens


      <400> 1611
 ggtggaattc cccactacct gcggggcgtg aacaacgcgc gccagccgtg gcacaacgcg     60
 gatgtccggc tgcggtacgg gctgcggccg gggaacgcca cggaggaggg cctggccagc    120
 ctgcacagcg tgctgttccg caagcagccg ttcctgtggc gcgctgcact gctctactac    180
 accatccacc gcgccgcgcg catgtccttc cgtcagctct tccaggacct ggagcgctac    240
 gtgcaggacg ccgatgtgcg ctgggagtac tgcgtgcgcg ccaagcgcgg ccagaccgac    300
 acctcgctgc caggttgttt cagcaaggac caggtgtacc tggacggcat cgtgcgcatt    360
 ctgcgacatc gccagaccat cgatttcccg ttgctgacct cactgggcaa ggtgtcctat    420
 gaggatgtgg accacctgcg gccccatggg gtgctggata atacccgggt gccccacttc    480
 atgcaggact tggcacgcta ccggcagcag ctggagcaca tcatggccac caaccggctg    540
 gatgaggcgg agctgggtcg cctgctaccc gactgatgtc cgttgagggc tgcagtcaga    600
 ggccctggac agaagctcca gataggcccc tagaacatga agcagtttgc tctgtgcgtc    660
 cacggcctag gtgtttcttg ggggtgttgg gagggcagga gcattccttg aggaggagtg    720
 gcaacatcaa agtgtttgtg tcccttgcca gcctccctgg ggtctgggga cctgcagcag    780
 catgtctggc aaactgagtc gccctcctgc ctccagctct ctgttgagca gagggaaggc    840
 atgggggcag gaagagagct gagcattgat ggggatgggg gtggtttggg aatagaaact    900
 tgttcttgca tgagatggct ttggatgcg                                      929



      <210> 1612
      <211> 1795
      <212> DNA
      <213> Homo sapiens


      <400> 1612
 ggctcgggct cggctccggg acgctgctct ccgtgtccga gtacaagaag aagtaccggg     60
 agcacgtgct gcagctgcac gctcgggtga aggagaggaa cgcccgctcc gtgaagatca    120
 ccaagcgctt caccaagctg ctcatcgcgc ccgagagcgc cgccccggag gaggcgctgg    180
 ggcccgcgga agagcctgag ccggggcgcg cgcggcgctc ggacacgcac actttcaacc    240
 gcctcttccg ccgcgacgag gagggccggc ggccgctgac cgtggtgctg cagggcccgg    300
 cgggcatcgg caagaccatg gcggccaaaa agatcctgta cgactgggcg gcgggcaagc    360
 tgtaccaggg ccaggtggac ttcgccttct tcatgccctg cggcgagctg ctggagaggc    420
 cgggcacgcg cagcctggct gacctgatcc tggaccagtg ccccgaccgc ggcgcgccgg    480
 tgccgcagat gctggcccag ccgcagcggc tgctcttcat cctggacggc gcggacgagc    540
 tgccggcgct ggggggcccc gaggccgcgc cctgcacaga ccccttcgag gcggcgagcg    600
 gcgcgcgggt gctaggcggg ctgctgagca aggcgctgct gcccacggcc ctcctgctgg    660
 tgaccacgcg cgccgccgcc cccgggaggc tgcagggccg cctgtgttcc ccgcagtgcg    720
 ccgaggtgcg cggcttctcc gacaaggaca agaagaagta tttctacaag ttcttccggg    780
 atgagaggag ggccgagcgc gcctaccgct tcgtgaagga gaacgagacg ctgttcgcgc    840
 tgtgcttcgt gcccttcgtg tgctggatcg tgtgcaccgt gctgcgccag cagctggagc    900
 tcggtcggga cctgtcgcgc acgtccaaga ccaccacgtc agtgtacctg cttttcatca    960
 ccagcgttct gagctcggct ccggtagccg acgggccccg gttgcagggc gacctgcgca   1020
 atctgtgccg cctggcccgc gagggcgtcc tcggacgcag ggcgcagttt gccgagaagg   1080
 aactggagca actggagctt cgtggctcca aagtgcagac gctgtttctc agcaaaaagg   1140
 agctgccggg cgtgctggag acagaggtca cctaccagtt catcgaccag agcttccagg   1200
 agttcctcgc ggcactgtcc tacctgctgg aggacggcgg ggtgcccagg accgcggctg   1260
 gcggcgttgg gacactcctg cgtggggacg cccagccgca cagccacttg gtgctcacca   1320
 cgcgcttcct cttcggactg ctgagcgcgg agcggatgcg cgacatcgag cgccacttcg   1380
 gctgcatggt ttcagagcgt gtgaagcagg aggccctgcg gtgggtgcag ggacagggac   1440
 agggctgccc cggagtggca ccagaggtga ccgagggggc caaagggctc gaggacaccg   1500
 aagagccaga ggaggaggag gagggagagg agcccaacta cccactggag ttgctgtact   1560
 gcctgtacga gacgcaggag gacgcgtttg tgcgccaagc cctgtgccgg ttcccggagc   1620
 tggcgctgca gcgagtgcgc ttctgccgca tggacgtggc tgttctgagc tactgcgtga   1680
 ggtgctgccc tgctggacag gcactgcggc tgatcagctg cagattggtt gctgcgcagg   1740
 agaagaagaa gaagagcctg gggaagcggc tccaggccag cctgggtggc ggcag        1795



      <210> 1613
      <211> 2177
      <212> DNA
      <213> Homo sapiens


      <400> 1613
 cggcttcgtg gaagcgggcg aggagtgtta ctgcgtttcc tggccaggag tgccgcgacc     60
 tctgctgctt tgctcacaac tgctcgctgc gcccgggggc ccagtgcgcc cacggggact    120
 gctgcgtgcg ctgcctgctg aagccggctg gagcgctgtg ccgccaggcc atgggtgact    180
 gtgacctccc tgagttttgc acgggcacct cctcccactg tcccccagac gtttacctac    240
 tggacggctc accctgtgcc aggggcagtg gctactgctg ggatggcgca tgtcccacgc    300
 tggagcagca gtgccagcag ctctgggggc ctggctccca cccagctccc gaggcctgtt    360
 tccaggtggt gaactctgcg ggagatgctc atggaaactg cggccaggac agcgagggcc    420
 acttcctgcc ctgtgcaggg agggatgccc tgtgtgggaa gctgcagtgc cagggtggaa    480
 agcccagcct gctcgcaccg cacatggtgc cagtggactc taccgttcac ctagatggcc    540
 aggaagtgac ttgtcgggga gccttggcac tccccagtgc ccagctggac ctgcttggcc    600
 tgggcctggt agagccaggc acccagtgtg gacctagaat ggtgtgccag agcaggcgct    660
 gcaggaagaa tgccttccag gagcttcagc gctgcctgac tgcctgccac agccacgggg    720
 tttgcaatag caaccataac tgccactgtg ctccaggctg ggctccaccc ttctgtgaca    780
 agccaggctt tggtggcagc atggacagtg gccctgtgca ggctgaaaac catgacacct    840
 tcctgctggc catgctcctc agcgtcctgc tgcctctgct cccaggggcc ggcctggcct    900
 ggtgttgcta ccgactccca ggagcccatc tgcagcgatg cagctggggc tgcagaaggg    960
 accctgcgtg cagtggcccc aaagatggcc cacacaggga ccaccccctg ggcggcgttc   1020
 accccatgga gttgggcccc acagccactg gacagccctg gcccctggac cctgagaact   1080
 ctcatgagcc cagcagccac cctgagaagc ctctgccagc agtctcgcct gacccccaag   1140
 cagatcaagt ccagatgcca agatcctgcc tctggtgaga ggtagctcct aaaatgaaca   1200
 gatttaaaga caggtggcca ctgacagcca ctccaggaac ttgaactgca ggggcagagc   1260
 cagtgaatca ccggacctcc agcacctgca ggcagcttgg aagtttcttc cccgagtgga   1320
 gcttcgaccc acccactcca ggaacccaga gccacattag aagttcctga gggctggaga   1380
 acactgctgg gcacactctc cagctcaata aaccatcagt cccagaagca aaggtcacac   1440
 agcccctgac ctccctcacc agtggaggct gggtagtgct ggccatccca aaagggctct   1500
 gtcctgggag tctggtgtgt ctcctacatg caatttccac ggacccagct ctgtggaggg   1560
 catgactgct ggccagaagc tagtggtcct ggggccctat ggttcgactg agtccacact   1620
 cccctggagc ctggctggcc tctgcaagca aacataattt tggggacctt ccttcctgtt   1680
 tcttcccacc ctgtcttctc ccctaggtgg ttcctgagcc cccaccccca atcccagtgc   1740
 tacacctgag gttctggagc tcagaatctg acagcctctc ccccattctg tgtgtgtcgg   1800
 ggggacagag ggaaccattt aagaaaagat accaaagtag aagtcaaaag aaagacatgt   1860
 tggctatagg cgtggtggct catgcctata atcccagcac tttgggaagc cggggtagga   1920
 ggatcaccag aggccaggag gtccacacca gcctgggcaa cacagcaaga caccgcatct   1980
 acagaaaaat tttaaaatta gctgggcgtg gtggtgtgta cctgtaggcc tagctgctca   2040
 ggaggctgaa gcaggaggat cacttgagcc tgagttcaac actgcagtga gctatggtgg   2100
 caccactgca ctccagcctg ggtgacagag caagacccct gtctctaaaa taaattttaa   2160
 aaagacatat tacactt                                                  2177



      <210> 1614
      <211> 1077
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1077)
      <223> n = a,t,c or g


      <400> 1614
 tttttttttt ttctgaacaa taaatgtttt atttgcttta aaagtgcctc tgaaagggcc     60
 ccccagaagt gagcagtgcg ccgtcaagcg ggtgtgcagg gcacacagct gcacggcaca    120
 gtgtgggtct gagtcactgc cggaggaggg accagggtgg tctgggccgc agccccttta    180
 acaatctgcc cttcctgccc tgcaggaaga acccattctg aacacaccct ggctgtccct    240
 ggctgcccca ctttggggtg acaaagagga ggcagccctg ggctgagtcc acagagacca    300
 gccctgatat ggcaggagtg ggggtggggt gggggagtgg gaatacagga gctcagcccc    360
 agctcaccac ggcatccccg aagagttgtg actcagacac acctgggttt aagtcccagc    420
 tgggggctca ggtaagtcaa atcgtcttct ggggcctctg tttatcagta gaaggctcca    480
 gaagtataca ctgttgatgg ctccttcccg ctctgatgca ccatgcctga ttaagcatac    540
 actgagcccc ctgggtcaga aatcgctgag gatgctgatg tcagcaaagt cagcccggta    600
 gcggtgggca tagaggctga gcaggaaggc ccacttgaag gaaatgaagc tccagacgct    660
 ggagaggtag tagctggtgg ggtctgtgag gctctgatgc cgggtgatgg ccagcacgag    720
 gaaggtgcag aaggcagcga tggagacggc cgagaagagg acgcccacga agaagaagcc    780
 gcgcagcccc ttgagccagg tcctccaata atcttgcatg tacatcacgt gcgtcaccag    840
 gacccacagt gccagcaccc ctgcgagccc tcccatggcc gcggtccccg gctgtcggta    900
 gaccaccgtc cagacgagga agatggagaa gccggccacg gagctgatgc cggagtaggc    960
 ggcgcggagg ccgagctgca gcctggacgg ggccatgggg ctgccgtacg cgtgggcgga   1020
 cgcgtgggtc gtcccgggcn ttccgcgacg gtactcaggg cgtcaggnnn ngcaccc      1077



      <210> 1615
      <211> 2457
      <212> DNA
      <213> Homo sapiens


      <400> 1615
 atggccctgc agaatgccct ctacaccggg gacctggcaa ggttgcagga gctgttcccc     60
 ccgcacagca cagccgacct gctgctggag agccgggccg cagagcctcg ctggagcagc    120
 caccagaggg cttgcccaat agcctacacc ttggcccaag aacacagtca tgtggagccc    180
 agaatagctc ctgctggatg cgtggccagg ctggtggaga agcccagcag agggtctgag    240
 gagcacctca agtctggccc gggacccatc gtcacccgca cagcctcagg acctgccctt    300
 gccttctggc aggcagtgct ggctggggac gtgggctgtg tctcccgcat cctcgcggac    360
 tccagtactg gcctggctcc tgattccgtc tttgatacca gcgacccaga gcgatggagg    420
 gatttccgct tcaacatccg tgctctgaga ctctggtctc tgacatacga agaggagctg    480
 accaccccac tgcatgtggc agccagccgt ggccacacgg aagtcctgcg gctgctgctg    540
 aggcggcgag caaggccaga cagtgcccct gggggccgca ccgccctgca cgaggcctgt    600
 gctgcaggcc acactgcctg tgttcatgtg ctgctggtgg caggagccga ccccaacatc    660
 gctgaccagg atgggaaacg ccccctgcat ctctgccggg ggcctggcac ccttgagtgt    720
 gcggagctgc tcctcaggtt tggagcgaga gtggatggtc ggtccgagga agaagaggag    780
 acccctttgc atgtggccgc ccggcttggc catgtggagc tggcagatct gcttctaaga    840
 cggggggcat gtcctgatgc ccgcaatgcc gaaggctgga ccccactgct ggctgcctgt    900
 gacgtccgct gccagtccat caccgatgcc gaggccacca ccgcccgctg cctgcagctg    960
 tgcagcttgc tgctttcagc tggagcagac gctgatgctg cggaccagga caagcagcga   1020
 cccctgcacc tggcctgccg ccgtggccat gcagctgtcg tggagctgct cctgtcctgt   1080
 ggtgtcagcg ccaacaccat ggactatggg ggacacacgc ccctgcactg tgctctgcag   1140
 ggcccagctg cagccctggc ccagagcccc gagcacgtgg ttcgggctct gctcaaccat   1200
 ggcgccgtcc gtgtctggcc aggggccctc cccaaggtgc tggagcgctg gagcacgtgc   1260
 cctcggacca tcgaggtcct gatgaacacc tacagtgttg tgcagcttcc cgaggaggcc   1320
 gtcggcctgg tgactcctga aactctgcag aaacatcagc gtttctactc ctccctcttc   1380
 gccttggtga ggcagcccag gtcgctgcag catttgagcc gctgtgcgct ccgctcccac   1440
 ctggagggca gcctgcccca agcgctgccc cgcctccccc tgccaccgcg cctgctccgc   1500
 tacctgcagc tggattttga gggcgtgagc cccgggatct gtgagcagtc acagctgctt   1560
 ggggtccagg gatgtgtgga aggcaagaga agggttgggg agggccctag ccagaaccgg   1620
 cccgtccccg aaccaccaga agcctctgaa tccaaacctc tccttccaga tgtccatggc   1680
 cttttgagag ggcctgaaag cagatgcccc agcctgcaga gggcgcgcct ctgcactaac   1740
 tcaggccagg tagccctggc agcaggaggc ccagctccgc aggcaggtgt ggatgctgca   1800
 attcccaatg cagagaagcg gaccgacagc ggcagccggc cgttccaggg cctgctgcgt   1860
 tcaggcaccg cgcacggggg caaggactgc cctccaggcc cccaccaggt ccgcttggcg   1920
 ggtagccgga gcgcggcgca caggaggaag cggcagttgt gcgctgctgc caccagaggg   1980
 cacccgcggc caggcccgac gctgcccacc atgagaggac tttctctggc caatgagtgg   2040
 attggagcct ctttcgccgg ccgccttacc aacaccttct gcgcggggct gggtcaggct   2100
 gtgccctcga tggtggcgct gaccaccgcg ctgcccagct tcgcggagcc gcccgacgct   2160
 ttctacgggc cccaggagct cgccgccgcc gctgccgccg ccgccgccac tgccgcccga   2220
 aacaaccccg agccaggcgg ccgacgccca gagggtgggc tggaagctga tgagctgctg   2280
 ccggcccggg agaaagtggc agagccccca ccacctccgc ctccgcactt ctcagagact   2340
 tttccaagtc tgcccggggt agacaagcta caaggatggg atttccgggg gcaccaagat   2400
 gggggtatgt tgaagcagct gtcaattcag caatggaggg cacgttctgg cttctaa      2457



      <210> 1616
      <211> 1456
      <212> DNA
      <213> Homo sapiens


      <400> 1616
 cccggtgcga cgatttcgtg gcgaaggtgc gggaacgtcc actcccgcgc gcccctctcg     60
 gggaccaggg cggcctccca ggaggagctt ggtttctggt cctcataccg tgtggttgag    120
 tgaaatcaaa acttccacga tagcaatgct gattggacaa agaatgtgtt gtggacacaa    180
 aaccaaactc tggaggacag aggattcatt ccaaggtaga gatggattcc tggaaatacc    240
 tcctcaaggc cagggtagag ccctcaatca cccactgccc ccagcttctc cttctcccat    300
 ctcctgcacc aagcaggtct ccaggtgttc cagctgctga tgacgtaaag tgtggagttg    360
 gtccaggaag gtcatgttcc atgcagcacg aggagcgctt tgtgtgagaa gttgaagacc    420
 tgctgtaaca catcatagag gaaagacata gcctggggcc ttctgcaact ggctgacttc    480
 caccttctcc tgggggaatc tgaagtcact tctgtccttt agacacaaga agggagagat    540
 tctcctcatt tggcccaaaa gcaccaaggt gttcctgcct agcaggccaa tggttctgag    600
 gcaggttata tcctagagat ccagaagagc cacagctgca cacctctagg gctgccagta    660
 gagggaagag gaggcccatt gagaaatcag gatgcttttg gcctggatga gctgaggtct    720
 tcataaaacc ttggatccta ggttctatga agacattcta tctatgcatg gctttaatgg    780
 agcacaaata gttttcattt ttctgagcat ttctctaaat ttttaattcc atttattgtt    840
 ttcatttaca tggcttctat atcagcatcc acaacctttt ggccaccagt ttggtggaag    900
 ataatttttc cacgaaaaat ggggtcaggg agggaatgct ttcagaggca ttagattctc    960
 attaggagac cacaacctag atccttcgca tctgcacttc acaatagggt tcctgctctt   1020
 ttgagaatcc aatgccactg ctgatctgac aggaggcaga gctcaggcgt taatgcttgt   1080
 tggttggcct gcttgcctcc tgctgtgcgg ccctgttcct accaggccag gaccagtacc   1140
 ccggtccatg gatgggggtg tgaaaaacct tgttctatat gacataaaag gaggtcgtcg   1200
 ctccacactc ttgatttttg caatggattg ttccaatatt cccagtaaac ttaagatata   1260
 tcaatccaaa tgaatattga tcaatcagat gagaaacgtc tgtgtgcata ctgttagaag   1320
 tatatacttt tagcccagat cctagcctcc agttttaccc tccattttgc ataggaaatc   1380
 aggatccctg ggccctatgg gtttctgtat tcagttagca aattacctat ctctggaaat   1440
 tcaacttttt aggact                                                   1456



      <210> 1617
      <211> 1634
      <212> DNA
      <213> Homo sapiens


      <400> 1617
 cggacgcgtg ggtttttttt tcgccggaaa tcccggaagt gacagctttg ggggtttgct     60
 gctggctctg actcccgtcc tgcgatgggt tgcgacgggg gaacaatccc caagaggcat    120
 gaactggtga aggggccgaa gaaggttgag aaggtcgaca aagatgctga attagtggcc    180
 caatggaact attgtactct aagtcaggaa atattaagac gaccaatagt tgcctgtgaa    240
 cttggcagac tttataacaa agatgccgtc attgaatttc tcttggacaa atctgcagaa    300
 aaggctcttg ggaaggcagc atctcacatt aaaagcatta agaatgtgac agagctgaag    360
 ctttctgata atcctgcctg ggaaggggat aaaggaaaca ctaaaggtga caagcacgat    420
 gacctccagc gggcgcgttt catctgcccc gttgtgggcc tggagatgaa cggccgacac    480
 aggttctgct tccttcggtg ctgcggctgt gtgttttctg agcgagcctt gaaagagata    540
 aaagcggaag tttgccacac gtgtggggct gccttccagg aggatgatgt catcgtgctc    600
 aatggcacca aggaggatgt ggacgtgctg aagacaagga tggaggagag aaggctgaga    660
 gcgaagctgg aaaagaaaac aaagaaaccc aaggcagcag agtctgtttc aaaaccagat    720
 gtcagtgaag aagccccagg gccatcaaaa gttaagacag ggaagcctga agaagccagc    780
 cttgattcta gagagaagaa aaccaacttg gctcccaaaa gcacagcaat gaatgagagc    840
 tcttctggaa aagctgggaa gcctccgtgt ggagccacaa agaggtccat cgctgacagt    900
 gaagaatcgg aggcctacaa gtccctcttt accactcaca gctccgccaa gcgctccaag    960
 gaggagtctg cccactgggt cacccacacg tcctactgct tctgaagccc gcactgccac   1020
 cgctcctgcc ccagaaggtt gtttagtttc cacgtaggca ggtcgctttg tgcctctgag   1080
 tgcgctgctg tgtgttctct ctatagttct gtgtcataaa gctgtcctgg ccagccttca   1140
 agctggtgtg gccactcttg atgtgaggcg tgtcggttcc aggggggaca tgggaggggc   1200
 tgcacagtgg cccgaggtca tgcttgcttc cacctgcagg tgcatttggt cctttccatg   1260
 gccaggaagc cctgtgggct gcacttttta tgcttgcagt aacaagagac tccagagtcc   1320
 tcaccggtgc agagttggca catattaatt aactaaaatt ctaatgatct tgctaccagc   1380
 aataaatcaa gtaggccaag tgaaactggg ctttaaaaag gatggatttc aaatacactg   1440
 tgcccactag aagcttcgaa gggcctcgtc cctctgctac agccctggga ggagccagga   1500
 tccttgttgg tctagctaaa tactgttagg ggagtgtgcc ccatctcatc atttcgaaga   1560
 tagcagagtc atagttgggc acccagtgat tgggttcaaa aataaagctg gtctgcctct   1620
 tctcaaaaaa aaaa                                                     1634



      <210> 1618
      <211> 1334
      <212> DNA
      <213> Homo sapiens


      <400> 1618
 tttcgtggac aggagggctg gcaagggagg gtccagggtt aggggattcg gagtggcttc     60
 aggcggacca cgtggctacc ttttttccag ggccagactt tggcagcgtg taaggtctga    120
 ggacaggggc accggaggcc gaggatgaga ggccagtgcc tgtttccagg cagccagggc    180
 ctcagaaact ccggccggag cactcacccg tcggtggagg ccgttaccag ggccacctta    240
 tttgcgagcg ggtcccggcg ggtcatcccg gagctggcca tccgcaccga attccaagcc    300
 cgggcacaga ggcctagcag ccccgccttg tgcatggatc agaccagcaa atgccacttc    360
 ggataaaccc tttggactcc taactccaat caggtgtctg ctttgttgag gactcacaga    420
 cacagtctcc tttcttcaag atctttacaa tgcaagacct cactaacaca cagggatggt    480
 ctcccagagg gtctgtgctg ttccttcact cagaacatca agatgcactg aagtaaggat    540
 cctctattct acagttcctg ctagctgagc tattccatgg gggcttcagc aggaaattcc    600
 aaggttggct ttgacaagct aaggccggct ggtggagcac atcgagttct ggaggttcat    660
 gtgtgttttc atgaagatct gtctgcccgt agcagataaa gagttgttgc cccactcctc    720
 ctggggtctt ctattttcct gggaggaatt tctggattaa ctgaacacac acacacacac    780
 acacaccctt ttgaagcatc aacagtaatt ctgagttctt agggacaatg cagattaaat    840
 ccacaataag aaagacaact atggccaggt gtggtggctc acggcctgta atcccagaac    900
 tttgggaggc tgaggcggat ggatcacctg aggtcaggag ttagagacca acctgaccaa    960
 catggagaaa ccccgtttct actaaaaatg caaaattagc cgggcatggt ggcaggcgcc   1020
 tgtaatccca aatactcggg aggctgaggc aggagaatca cttaaacccg ggaggcagag   1080
 gttgcagtga gccaagatcg cgccattgca ctccagcctg ggcaagaaga gcaaaactcc   1140
 atctcaaaaa aaaaaaaaga gtcctatggt tccaaagggg accaaacggc cctcattgga   1200
 aaaaataggg gactttatta tgcaaggggg ttccagtccc ttggtttggt tttgggaaaa   1260
 gaaaaaaagg cctacaatcc aaaaaaatag ggcccatcac aggcttcccc aagggacaaa   1320
 attaatccat tttt                                                     1334



      <210> 1619
      <211> 348
      <212> DNA
      <213> Homo sapiens


      <400> 1619
 ggcttactca ctataggctc gagcggccgc ccgggcaggt ttttcgtctt atttgaagtc     60
 attgccggat gtgaggaaaa aatcgcttcc cttgcctgaa aagccacaca aagaagaaaa    120
 ttcagaaatc gtggtttgga gagaatttga caagcaagtg ttcctcttga actgaagccc    180
 ccggagacaa tcgaagctgt acacggtgga cctggagtca gggctacact acctcctgcg    240
 ggtggagctg gcagcccaca agtccctggc cggagcagag ctgaagacgc tcaaggactt    300
 tgtgactgtc ttggccaagc tgttccctgg acggccgcca gtcaagcc                 348



      <210> 1620
      <211> 1209
      <212> DNA
      <213> Homo sapiens


      <400> 1620
 atggccctct cctcctggcc agtggtcctc cgcctgaaca tggccgactt tgtcttcagt     60
 ttcctctgcc tcggcattgg aaccagcatc gtactgggta tcctgttcta cctgctgcag    120
 gcccacaggt acctgcagga aggcatgacc taccagctgg cactcagctt ctacctgacc    180
 tgggccagtg tcttcctctt cctgatgact ggtatgggag aggatgagga aagtgccctt    240
 cagactctct tagatccccg aagctcctac ctcctggtct ccctggagat cctcccaaca    300
 aatcccagtc ccctgtcacc ttgtgctgtg tccgaggatg aaagcgagat gagggggctt    360
 tctctgctcc gtcgtcagtc ccaggcaacc ggcagacttg agcccacgtt caagcatgac    420
 agcaccctgc tggccctcca gggggccctg ggcctctatg atggacacac cccgccatat    480
 gctgcctgcc tcggctttga gttccggaag cacctgggga atcccgccaa agatggaggg    540
 aatgtcaccg tctccctctt ctaccgcaat gactccgccc acctgcccct gcctctcagc    600
 ctccccgggt gcccggcccc ctgtccacta ggccgcttct accagctgac tgccccggca    660
 cggcctcccg cccatggggt ctcctgccat ggcccatatg aggctgtcat ccccccaggg    720
 cctggagcta tcataccaag cacagggcca gctgtgggca tgcagagaga gaggtctgaa    780
 gtggggagtg gcgtgcctgc aaggacggtt tatgcatcag aacagcacgc ctatatgtgg    840
 cattcggcgc tgattcctga ctctggtctg cgtgggaaac ctactctctc ctccaggaag    900
 cccccccaga cttcctgcgg gccagagttt gccaatgtcc tctccctggc tctctgcgga    960
 gcgctggtag tgtgcaaggc cagagccatg gaccaggcga ggcctcggca gctgattgga   1020
 atagatgcat taagggatcc cagggcaagt agtagaacaa gggcaggagg cctgggcatg   1080
 attcgacggc aggaggaaga accagcggcc cgcacggtgc ttgccaggtg cgactcaagc   1140
 cccagcgagt gcccgagcca tgcacgggcg ccatacgaca ctggccccct ttttaacgcg   1200
 aagggctaa                                                           1209



      <210> 1621
      <211> 2098
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2098)
      <223> n = a,t,c or g


      <400> 1621
 aatggaggtg ggagtttaaa taactattcc tctcccattc catcgactcc agcacccagc     60
 aggagggacc ctcagttcag tgttcctccc actgccaaca cacccacgcc cgtttgcaag    120
 cggtccatgc gctggtccaa cctgtttaca tctgagaaag ggagtgaccc agacaaagag    180
 aggaaagccc cggagaatca tgctgatacc atcgggagcg gtagagccat ccccattaaa    240
 cagggcatgc tcttaaagcg aagtgggaaa tggctgaaga catggaaaaa gaaatacgtc    300
 accctgtgtt ccaatggcat gctcacctat tattcaagct taggtgatta tatgaagaat    360
 attcataaaa aagagattga ccttcagaca tctaccatca aagtcccagg aaagtggcca    420
 tccctagcca catcggcctg cacacccatc tccagctcta aaagcaatgg cctatccaag    480
 gacatggaca ccgggctggg tgactccata tgcttcagcc ccagtatctc cagcaccacc    540
 agccccaagc tcaacccgcc cccctctcct catgccaata aaaagaaaca cctaaagaag    600
 aaaagcacca acaactttat gattgtgtct gccactggcc aaacgtggca ctttgaagcc    660
 acgacgtatg aggagcggga tgcctgggtc caagccatcc agagccagat cctggccagc    720
 ctgcagtcat gcgagagcag taaaagcaag tcccagctga ccagccagag cgaggccatg    780
 gccctgcagt cgatccaaaa catgcgtggg aacgcccact gtgtggactg tgagacccag    840
 aatcctaagt gggccagttt gaacttggga gtcctcatgt gtattgaatg ctcaggtatc    900
 caccgcagtc ttggccccca cctttcccgt gtgcgatctc tggagctgga tgactggcca    960
 gttgagctca ggaaggttat gtcatctatt gtcaatgacc tagccaacag catctgggaa   1020
 gggagcagcc aggggcagac aaaaccctca gaaaagtcca cgagggaaga gaaggaacgg   1080
 tggatccgtt ccaaatatga ggagaagctc tttctggccc cactaccctg cactgagctg   1140
 tccctgggcc agcagctgct gcgggccacc gctgatgagg acctgcagac agccatcctg   1200
 ctgctggcac atggctcctg tgaggaggtg aacgagacct gtggggaggg agacggctgc   1260
 acggcgctcc atctggcctg ccgcaagggg aatgtggtcc tggcgcagct cctgatctgg   1320
 tacggggtgg acgtcatggc ccgagatgcc cacgggaaca cagcgctgac ctacgcccgg   1380
 caggcctcca gccaggagtg catcaacgtg cttctgcagt acggctgccc cgacgagtgt   1440
 gtatagtatc tgttttattt gactgcagtc tccttggtgc aaaaacaaaa tgggaaaaat   1500
 aaggataact cagaatttca aaaggaaatc acaaattcag ctaataatag cattttcagt   1560
 acttttcgta aactaagtaa atacacaaaa tgttgatttt tctgaccata agacgtattt   1620
 tatgtccttt tgccaaggtg gatttgttag tctcaggccc tcctggccac attgcccaag   1680
 tcacacaggc ttctgtatta tgtatttaga taaaatgtgt gaaaatatat ttgaaataaa   1740
 gttcataaat atgcattgat ttttgtacaa aaaaaaaaaa aaggggggcc ctttttagag   1800
 atcccttggg gggcccaatt tttccggggg ttggcaagtt tttatttttt tctttttggg   1860
 gggcgttttt aaaccctctt tgggtttttt gggaaagaac cttttttttg ggggggggac   1920
 ttattggccc accctccctc caaattttaa ggcttttggg gaaaataaaa atttttaagg   1980
 ggtaaagggg gaaaaccacc cccctttccc tggctgttaa aaatgnngnn nnnnnnnnnn   2040
 anaacccccc ctctcggggg gggcaatggg gcccccccct ctttaaggag atagagct     2098



      <210> 1622
      <211> 2098
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2098)
      <223> n = a,t,c or g


      <400> 1622
 aatggaggtg ggagtttaaa taactattcc tctcccattc catcgactcc agcacccagc     60
 aggagggacc ctcagttcag tgttcctccc actgccaaca cacccacgcc cgtttgcaag    120
 cggtccatgc gctggtccaa cctgtttaca tctgagaaag ggagtgaccc agacaaagag    180
 aggaaagccc cggagaatca tgctgatacc atcgggagcg gtagagccat ccccattaaa    240
 cagggcatgc tcttaaagcg aagtgggaaa tggctgaaga catggaaaaa gaaatacgtc    300
 accctgtgtt ccaatggcat gctcacctat tattcaagct taggtgatta tatgaagaat    360
 attcataaaa aagagattga ccttcagaca tctaccatca aagtcccagg aaagtggcca    420
 tccctagcca catcggcctg cacacccatc tccagctcta aaagcaatgg cctatccaag    480
 gacatggaca ccgggctggg tgactccata tgcttcagcc ccagtatctc cagcaccacc    540
 agccccaagc tcaacccgcc cccctctcct catgccaata aaaagaaaca cctaaagaag    600
 aaaagcacca acaactttat gattgtgtct gccactggcc aaacgtggca ctttgaagcc    660
 acgacgtatg aggagcggga tgcctgggtc caagccatcc agagccagat cctggccagc    720
 ctgcagtcat gcgagagcag taaaagcaag tcccagctga ccagccagag cgaggccatg    780
 gccctgcagt cgatccaaaa catgcgtggg aacgcccact gtgtggactg tgagacccag    840
 aatcctaagt gggccagttt gaacttggga gtcctcatgt gtattgaatg ctcaggtatc    900
 caccgcagtc ttggccccca cctttcccgt gtgcgatctc tggagctgga tgactggcca    960
 gttgagctca ggaaggttat gtcatctatt gtcaatgacc tagccaacag catctgggaa   1020
 gggagcagcc aggggcagac aaaaccctca gaaaagtcca cgagggaaga gaaggaacgg   1080
 tggatccgtt ccaaatatga ggagaagctc tttctggccc cactaccctg cactgagctg   1140
 tccctgggcc agcagctgct gcgggccacc gctgatgagg acctgcagac agccatcctg   1200
 ctgctggcac atggctcctg tgaggaggtg aacgagacct gtggggaggg agacggctgc   1260
 acggcgctcc atctggcctg ccgcaagggg aatgtggtcc tggcgcagct cctgatctgg   1320
 tacggggtgg acgtcatggc ccgagatgcc cacgggaaca cagcgctgac ctacgcccgg   1380
 caggcctcca gccaggagtg catcaacgtg cttctgcagt acggctgccc cgacgagtgt   1440
 gtatagtatc tgttttattt gactgcagtc tccttggtgc aaaaacaaaa tgggaaaaat   1500
 aaggataact cagaatttca aaaggaaatc acaaattcag ctaataatag cattttcagt   1560
 acttttcgta aactaagtaa atacacaaaa tgttgatttt tctgaccata agacgtattt   1620
 tatgtccttt tgccaaggtg gatttgttag tctcaggccc tcctggccac attgcccaag   1680
 tcacacaggc ttctgtatta tgtatttaga taaaatgtgt gaaaatatat ttgaaataaa   1740
 gttcataaat atgcattgat ttttgtacaa aaaaaaaaaa aaggggggcc ctttttagag   1800
 atcccttggg gggcccaatt tttccggggg ttggcaagtt tttatttttt tctttttggg   1860
 gggcgttttt aaaccctctt tgggtttttt gggaaagaac cttttttttg ggggggggac   1920
 ttattggccc accctccctc caaattttaa ggcttttggg gaaaataaaa atttttaagg   1980
 ggtaaagggg gaaaaccacc cccctttccc tggctgttaa aaatgnngnn nnnnnnnnnn   2040
 anaacccccc ctctcggggg gggcaatggg gcccccccct ctttaaggag atagagct     2098



      <210> 1623
      <211> 2098
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2098)
      <223> n = a,t,c or g


      <400> 1623
 aatggaggtg ggagtttaaa taactattcc tctcccattc catcgactcc agcacccagc     60
 aggagggacc ctcagttcag tgttcctccc actgccaaca cacccacgcc cgtttgcaag    120
 cggtccatgc gctggtccaa cctgtttaca tctgagaaag ggagtgaccc agacaaagag    180
 aggaaagccc cggagaatca tgctgatacc atcgggagcg gtagagccat ccccattaaa    240
 cagggcatgc tcttaaagcg aagtgggaaa tggctgaaga catggaaaaa gaaatacgtc    300
 accctgtgtt ccaatggcat gctcacctat tattcaagct taggtgatta tatgaagaat    360
 attcataaaa aagagattga ccttcagaca tctaccatca aagtcccagg aaagtggcca    420
 tccctagcca catcggcctg cacacccatc tccagctcta aaagcaatgg cctatccaag    480
 gacatggaca ccgggctggg tgactccata tgcttcagcc ccagtatctc cagcaccacc    540
 agccccaagc tcaacccgcc cccctctcct catgccaata aaaagaaaca cctaaagaag    600
 aaaagcacca acaactttat gattgtgtct gccactggcc aaacgtggca ctttgaagcc    660
 acgacgtatg aggagcggga tgcctgggtc caagccatcc agagccagat cctggccagc    720
 ctgcagtcat gcgagagcag taaaagcaag tcccagctga ccagccagag cgaggccatg    780
 gccctgcagt cgatccaaaa catgcgtggg aacgcccact gtgtggactg tgagacccag    840
 aatcctaagt gggccagttt gaacttggga gtcctcatgt gtattgaatg ctcaggtatc    900
 caccgcagtc ttggccccca cctttcccgt gtgcgatctc tggagctgga tgactggcca    960
 gttgagctca ggaaggttat gtcatctatt gtcaatgacc tagccaacag catctgggaa   1020
 gggagcagcc aggggcagac aaaaccctca gaaaagtcca cgagggaaga gaaggaacgg   1080
 tggatccgtt ccaaatatga ggagaagctc tttctggccc cactaccctg cactgagctg   1140
 tccctgggcc agcagctgct gcgggccacc gctgatgagg acctgcagac agccatcctg   1200
 ctgctggcac atggctcctg tgaggaggtg aacgagacct gtggggaggg agacggctgc   1260
 acggcgctcc atctggcctg ccgcaagggg aatgtggtcc tggcgcagct cctgatctgg   1320
 tacggggtgg acgtcatggc ccgagatgcc cacgggaaca cagcgctgac ctacgcccgg   1380
 caggcctcca gccaggagtg catcaacgtg cttctgcagt acggctgccc cgacgagtgt   1440
 gtatagtatc tgttttattt gactgcagtc tccttggtgc aaaaacaaaa tgggaaaaat   1500
 aaggataact cagaatttca aaaggaaatc acaaattcag ctaataatag cattttcagt   1560
 acttttcgta aactaagtaa atacacaaaa tgttgatttt tctgaccata agacgtattt   1620
 tatgtccttt tgccaaggtg gatttgttag tctcaggccc tcctggccac attgcccaag   1680
 tcacacaggc ttctgtatta tgtatttaga taaaatgtgt gaaaatatat ttgaaataaa   1740
 gttcataaat atgcattgat ttttgtacaa aaaaaaaaaa aaggggggcc ctttttagag   1800
 atcccttggg gggcccaatt tttccggggg ttggcaagtt tttatttttt tctttttggg   1860
 gggcgttttt aaaccctctt tgggtttttt gggaaagaac cttttttttg ggggggggac   1920
 ttattggccc accctccctc caaattttaa ggcttttggg gaaaataaaa atttttaagg   1980
 ggtaaagggg gaaaaccacc cccctttccc tggctgttaa aaatgnngnn nnnnnnnnnn   2040
 anaacccccc ctctcggggg gggcaatggg gcccccccct ctttaaggag atagagct     2098



      <210> 1624
      <211> 2098
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2098)
      <223> n = a,t,c or g


      <400> 1624
 aatggaggtg ggagtttaaa taactattcc tctcccattc catcgactcc agcacccagc     60
 aggagggacc ctcagttcag tgttcctccc actgccaaca cacccacgcc cgtttgcaag    120
 cggtccatgc gctggtccaa cctgtttaca tctgagaaag ggagtgaccc agacaaagag    180
 aggaaagccc cggagaatca tgctgatacc atcgggagcg gtagagccat ccccattaaa    240
 cagggcatgc tcttaaagcg aagtgggaaa tggctgaaga catggaaaaa gaaatacgtc    300
 accctgtgtt ccaatggcat gctcacctat tattcaagct taggtgatta tatgaagaat    360
 attcataaaa aagagattga ccttcagaca tctaccatca aagtcccagg aaagtggcca    420
 tccctagcca catcggcctg cacacccatc tccagctcta aaagcaatgg cctatccaag    480
 gacatggaca ccgggctggg tgactccata tgcttcagcc ccagtatctc cagcaccacc    540
 agccccaagc tcaacccgcc cccctctcct catgccaata aaaagaaaca cctaaagaag    600
 aaaagcacca acaactttat gattgtgtct gccactggcc aaacgtggca ctttgaagcc    660
 acgacgtatg aggagcggga tgcctgggtc caagccatcc agagccagat cctggccagc    720
 ctgcagtcat gcgagagcag taaaagcaag tcccagctga ccagccagag cgaggccatg    780
 gccctgcagt cgatccaaaa catgcgtggg aacgcccact gtgtggactg tgagacccag    840
 aatcctaagt gggccagttt gaacttggga gtcctcatgt gtattgaatg ctcaggtatc    900
 caccgcagtc ttggccccca cctttcccgt gtgcgatctc tggagctgga tgactggcca    960
 gttgagctca ggaaggttat gtcatctatt gtcaatgacc tagccaacag catctgggaa   1020
 gggagcagcc aggggcagac aaaaccctca gaaaagtcca cgagggaaga gaaggaacgg   1080
 tggatccgtt ccaaatatga ggagaagctc tttctggccc cactaccctg cactgagctg   1140
 tccctgggcc agcagctgct gcgggccacc gctgatgagg acctgcagac agccatcctg   1200
 ctgctggcac atggctcctg tgaggaggtg aacgagacct gtggggaggg agacggctgc   1260
 acggcgctcc atctggcctg ccgcaagggg aatgtggtcc tggcgcagct cctgatctgg   1320
 tacggggtgg acgtcatggc ccgagatgcc cacgggaaca cagcgctgac ctacgcccgg   1380
 caggcctcca gccaggagtg catcaacgtg cttctgcagt acggctgccc cgacgagtgt   1440
 gtatagtatc tgttttattt gactgcagtc tccttggtgc aaaaacaaaa tgggaaaaat   1500
 aaggataact cagaatttca aaaggaaatc acaaattcag ctaataatag cattttcagt   1560
 acttttcgta aactaagtaa atacacaaaa tgttgatttt tctgaccata agacgtattt   1620
 tatgtccttt tgccaaggtg gatttgttag tctcaggccc tcctggccac attgcccaag   1680
 tcacacaggc ttctgtatta tgtatttaga taaaatgtgt gaaaatatat ttgaaataaa   1740
 gttcataaat atgcattgat ttttgtacaa aaaaaaaaaa aaggggggcc ctttttagag   1800
 atcccttggg gggcccaatt tttccggggg ttggcaagtt tttatttttt tctttttggg   1860
 gggcgttttt aaaccctctt tgggtttttt gggaaagaac cttttttttg ggggggggac   1920
 ttattggccc accctccctc caaattttaa ggcttttggg gaaaataaaa atttttaagg   1980
 ggtaaagggg gaaaaccacc cccctttccc tggctgttaa aaatgnngnn nnnnnnnnnn   2040
 anaacccccc ctctcggggg gggcaatggg gcccccccct ctttaaggag atagagct     2098



      <210> 1625
      <211> 415
      <212> DNA
      <213> Homo sapiens


      <400> 1625
 gggcggcttt gcggcagctg ttgaatcctt ccatcatgaa gatgtgctgt tgtttgcagc     60
 cctgatggcc catgagctcg ggcacaacct gggtattcag cacgaccact cggcctgctt    120
 ttgtaaagat aagcactttt gcctcatgca tgaaaatatc acaaaagaaa gtggcttcag    180
 cagctgcagc tctgactact tctaccagtt ccttcgagaa cacaaagggg cctgcctatt    240
 taacaagcca cggcccaggg gccgcaagcg tagggattct gcctgtggaa atggtgtggt    300
 ggaggacacg gatcagtgtg actgtggttc tctatgtcag catcatgcat gctgtgatga    360
 aaactgtata ctgaaggcga aagcatagtg caatgatggt ccatgttgtc ataag         415



      <210> 1626
      <211> 434
      <212> DNA
      <213> Homo sapiens


      <400> 1626
 tctaaatcac tcatcattgg ttaaagccga gctcacagca gaataagcca ccatgaggct     60
 gtcggtgtgt ctcctgctgc tcacgctggc cctttgctgc taccgggcaa atgcagtggt    120
 ctgccaagct cttggttctg aaatcacagg cttcttatta gctggaaaac ctgtgttcaa    180
 gttccaactt gccaaattta aggcacctct ggaagctgtt gcagccaaga tggaagtgaa    240
 gaaatgcgtg gatacgatgg cctatgagaa aagagtgcta attacaaaaa cattgggaaa    300
 aatagcagag aaatgtgatc gctgagatgt aaaaagtttt taatgctagt ttccaccatc    360
 tttcaatgat accctgatct tcactgcaga atgtaaaggt ttcaacgtct tgctctaata    420
 aatcacttgc cctg                                                      434



      <210> 1627
      <211> 422
      <212> DNA
      <213> Homo sapiens


      <400> 1627
 gtcggtgaga atccagggag aggagcggaa acagaagagg ggcagaagac cggggcactt     60
 gtgggttgca gagcccctca gccatgttgg gagccaagcc acactggcta ccaggtcccc    120
 tacacagtcc cgggctgccc ttggttctgg tgcttctggc cctgggggcc gggtgggccc    180
 aggaggggtc agagcccgtc ctgctggagg gggagtgcct ggtggtctgt gagcctggcc    240
 gagctgctgc aggggggccc gggggagcag ccctgggaga ggcaccccct gggcgagtgg    300
 catttgctgc ggtccgaagc caccaccatg agccagcagg ggaaaccggc aatggcacca    360
 gtggggccat ctacttcgac caggtcctgg tgaacgaggg cggtggcttt gaccgggcct    420
 ct                                                                   422



      <210> 1628
      <211> 925
      <212> DNA
      <213> Homo sapiens


      <400> 1628
 ggctcgccgg gaccagatcc gcgagcccgt cagcctgcgc catgggctgc gacggccgcg     60
 tgtcggggct gctccgccgc aacctgcagc ccacgctcac ctactggagc gtcttcttca    120
 gcttcggcct gtgcatcgcc ttcctggggc ccacgctgct ggacctgcgc tgtcagacgc    180
 acagctcgct gccccagatc tcctgggtct tcttctcgca gcagctctgc ctcctgctgg    240
 gcagcgccct cgggggcgtc ttcaaaagga ccctggccca gtcactatgg gccctgttca    300
 cctcctctct ggccatctcc ctggtgtttg ccgtcatccc cttctgccgc gacgtgaagg    360
 tgctggcctc agtcatggcg ctggcgggct tggccatggg ctgcatcgac accgtggcca    420
 acatgcagct ggtaaggatg taccagaagg actcggccgt cttcctccag gtgctccatt    480
 tcttcgtggg ctttggtgct ctgctgagcc cccttattgc tgaccctttc ctgtctgagg    540
 ccaactgctt gcctgccaat agcacgggcc aacaccacct cccgagggcc acctgttcca    600
 tgtctccagg gtgctggggc cagcaccacg tagatgccca ggccttggtc caaccagacg    660
 ttcccaaggc tgactcccaa ggaccgggca gggaacccga ggggcctatg ccttctggat    720
 aatggccctt attaatcttt ccaaggccca tggctgggct tgaagctgct ggccccaggg    780
 aacggcttgt tggaactgct cgtcccccac agggggcccc ccgcttcctg gactgggaaa    840
 gaaacttgcc tttgaaaaca ccagccctct tggaagaaga agacaaacct ccctcaaaag    900
 gcctatagtt tatactaacg cctac                                          925



      <210> 1629
      <211> 925
      <212> DNA
      <213> Homo sapiens


      <400> 1629
 ggctcgccgg gaccagatcc gcgagcccgt cagcctgcgc catgggctgc gacggccgcg     60
 tgtcggggct gctccgccgc aacctgcagc ccacgctcac ctactggagc gtcttcttca    120
 gcttcggcct gtgcatcgcc ttcctggggc ccacgctgct ggacctgcgc tgtcagacgc    180
 acagctcgct gccccagatc tcctgggtct tcttctcgca gcagctctgc ctcctgctgg    240
 gcagcgccct cgggggcgtc ttcaaaagga ccctggccca gtcactatgg gccctgttca    300
 cctcctctct ggccatctcc ctggtgtttg ccgtcatccc cttctgccgc gacgtgaagg    360
 tgctggcctc agtcatggcg ctggcgggct tggccatggg ctgcatcgac accgtggcca    420
 acatgcagct ggtaaggatg taccagaagg actcggccgt cttcctccag gtgctccatt    480
 tcttcgtggg ctttggtgct ctgctgagcc cccttattgc tgaccctttc ctgtctgagg    540
 ccaactgctt gcctgccaat agcacgggcc aacaccacct cccgagggcc acctgttcca    600
 tgtctccagg gtgctggggc cagcaccacg tagatgccca ggccttggtc caaccagacg    660
 ttcccaaggc tgactcccaa ggaccgggca gggaacccga ggggcctatg ccttctggat    720
 aatggccctt attaatcttt ccaaggccca tggctgggct tgaagctgct ggccccaggg    780
 aacggcttgt tggaactgct cgtcccccac agggggcccc ccgcttcctg gactgggaaa    840
 gaaacttgcc tttgaaaaca ccagccctct tggaagaaga agacaaacct ccctcaaaag    900
 gcctatagtt tatactaacg cctac                                          925



      <210> 1630
      <211> 474
      <212> DNA
      <213> Homo sapiens


      <400> 1630
 cactggtccc accatcaaga atatggatgg cacatttaat gtcactagct gcttgaagct     60
 gaactcctct caggaagacc ctgggactgt ctaccagtgt gtggtacggc atgcgtcctt    120
 gcataccccc ttgaggagca actttaccct gactgctgct cggcacagtc tttctgaaac    180
 tgagaagaca gataattttt ccattcattg gtggcctatt tcattcattg gtgttggact    240
 ggttttatta attgttttga ttccttggaa aaagatatgt aacaaatcat cttcagccta    300
 tactcctctc aagtgcattc tgaaacactg gaactccttt gacactcaga ctctgaagaa    360
 agagcacctc atattctttt gcactcgggc atggccgtct taccagctgc aggatgggga    420
 ggcttggcct cctgagggaa gtgttaatat taatacatat tcaacaactg tatt          474



      <210> 1631
      <211> 5830
      <212> DNA
      <213> Homo sapiens


      <400> 1631
 cggccgcggc gacagctcca gctccggctc cggctccggc tccggctccg gctcccgcgc     60
 ctgccccgct cggcccagcg cgcccgggct ccgcgccccg accccgccgc cgcgcctgcc    120
 gggggcctcg ggcgcccccg ccgcccgcct cacgctgaag ttcctggccg tgctgctggc    180
 cgcgggcatg ctggcgttcc tcggtgccgt catctgcatc atcgccagcg tgcccctggc    240
 ggccagcccg gcgcgggcgc tgcccggcgg cgccgacaat gcttcggtcg cctcgggcgc    300
 cgccgcgtcc ccgggcccgc agcggagcct gagcgcgctg cacggcgcgg gcggttcagc    360
 cgggcccccc gcgctgcccg gggcacccgc ggccagcgcg cacccgctgc cgcccgggcc    420
 cctgttcagc cgcttcctgt gcacgccgct ggctgctgcc tgcccgtcgg gggcccagca    480
 gggggacgcg gcgggcgctg cgccgggcga gcgcgaagag ctgctgctgc tgcagagcac    540
 ggccgagcag ctgcgccaga cggcgctgca gcaggaggcg cgcatccgcg ccgaccagga    600
 caccatccgt gagctcaccg gcaagctggg ccgctgcgag agcggcctgc cgcgcggcct    660
 ccagggcgcc gggccccgcc gcgacaccat ggccgacggg ccctgggact cgcctgcgct    720
 cattctggag ctggaggacg ccgtgcgcgc cctgcgggac cgcatcgacc gcctggagga    780
 gcttccagcc cgtgtgaacc tctcagctgc cccagcccca gtctctgctg tgcccaccgg    840
 cctacactcc aagatggacc agctggaggg gcagctgctg gcccaggtgc tggcactgga    900
 gaaggagcgt gtggccctca gccacagcag ccgccggcag aggcaggaag tggaaaagga    960
 gttggacgtc ctgcagggtc gtgtggctga gctggagcac gggtcctcag cctacagtcc   1020
 tccagatgcc ttcaagatca gcatccccat ccgtaacaac tacatgtacg cccgcgtgcg   1080
 gaaggctctg cccgagctct acgcattcac cgcctgcatg tggctgcggt ccaggtccag   1140
 cggcaccggc cagggcaccc ccttctccta ctcagtgccc gggcagcagg caacgagatt   1200
 gtactgctag aggcgggcca tgagcccatg gagctgctga tcaacgacaa ggtggcccag   1260
 ctgcccctga gcctgaagga caatggctgg caccacatct gcatcgcctg gaccacaagg   1320
 gatggcctat ggtctgccta ccaggacggg gagctgcagg gctccggtga gaacctggct   1380
 gcctggcacc ccatcaagcc tcatgggatc cttatcttgg gccaggagca ggataccctg   1440
 ggtggccggt ttgatgccac ccaggccttt gtcggtgaca ttgcccagtt taacctgtgg   1500
 gaccacgccc tgacaccagc ccaggtcctg ggcattgcca actgcactgc gccactgctg   1560
 ggcaacgtcc ttccctggga agacaagttg gtggaggcct ttgggggtgc aacaaaggct   1620
 gccttcgatg tctgcaaggg gagggccaag gcatgagggg ccacctcatc cagggcccct   1680
 cccttgcctg ccactttggg gacttgaggg gggtcatatt ccctcctcag cctgcccacg   1740
 cactggcctt ccctcctgcc ccactcctgg ctgtgcctcc catttcccct cacctgtacc   1800
 cacacctcca gaatgccctg ccctgcgagt gtgtcccctg tccccacctg agtggggagg   1860
 agcgtctcaa gtgaacagtg ggagcctgcc cacctggcac tgcactggag ttgtctctta   1920
 ccccaccctc cctgcccatc aactgtatct gatttcacta attttgacag cacccccagt   1980
 agggtaggat tgtgtatgag ggggacccca ctatctcagt ggtgggggtg gccgcccgcc   2040
 cccttgtccc ccatgcaaca ggcccagtgg cttccccttc agggccacaa caggctgtag   2100
 aaggggatga cgaggacatc agaggttaga cttaccctcc tccctctttc caccagctgc   2160
 cagtcaaggg cagtgggatc tcgatggagc ctcccccccc ccacccatgc ctccctcttc   2220
 ctcctctttc ctcctctctt tgtgtgtaac ggtttgaatg ttggttccat gcctggccca   2280
 accccacctc agtctccagg acattccttt cccagctcca gcctggaggg aaggggacaa   2340
 agaccccagg aggccaaagg gctgcagtca ccccttgtgc tcacccatag tgatggccac   2400
 tggtatagtc atcgctctcc ctccatgcca aggacaggac ttggaccgct tcagcctggg   2460
 ctgggagcag ccctaaggta gaggcctcat ggcccaggag accccacctc tggcagagcc   2520
 acattaccta ccctgtgcat ggtcctgggg cagcaaggaa gaagctcaga gggtggggag   2580
 aagcatgaag cagtgagcag agcactgggt gagagggaga agaccttggt tcctagccag   2640
 ccctgctaat gtgctgtgtg gccttctgta agtccctgcc ctctctgggc ctggccttcc   2700
 tcattcgtga gctgaggccc tcgctttggt catttgctct ccagattggg tgtgagcttc   2760
 tctgtgattc caggtggata tgtggggaaa gctctggtga ccctgggctt cgcagggtgt   2820
 agatcccagg actcggcagt ggatgggatg cagccagtca tgggttaggg tcagcagaga   2880
 ctcagagtcc agggcaaggt tcaaggcaga ctaacctcat gcatggattg taaaaaacca   2940
 gctccctttg gatcaaccca gcctggcacc cttgcctgtc tgagagtgtc tcaaagggct   3000
 gatggcttcc tggtcccctt gagtcatcac cagcttcccc aagagagtgt cagaatctta   3060
 agagctgaga ggccgggcac ggtggctcac gcctgtaatc ccagcacttt gggaggctga   3120
 gacaggcaga tcacttgagg tcaggagttc gaggtcagcc tggccaacgt ggtgaaaccc   3180
 catcttcact aaaaatacaa aacttaactg gttaggtggt gcatgcctgt agtcccagct   3240
 actcgggagg ccgaggcaga agaatctctt gaactgagga ggtggaggtt gcagtgagcc   3300
 gagatcacgc cattgcactc cagcctgggc aacagagcaa gactccatct caaaaaaaaa   3360
 taataataat cttaaagatg agaaaagcca ccccatctgg caccacagct gcatcttgct   3420
 tgtgagaaat ggggaagagt tcagggagga cacgtgacct gcacaggatc acagagcatg   3480
 gggcagagcc aggactagag ctcagggcat ctgactccct cttcagtgtt cttccccctc   3540
 catgttgcct gcccctgaag acctttgagt tcagtctaca cctaagcagg tagacatccg   3600
 cgaagtcaga tgctttccaa catgacacct gaacatcttc ctttatgcaa cacccaaaca   3660
 tcttggcatc cccaccccag gaagtgcggg gaggaggtta tgatccctgg gcgcttcggc   3720
 agaatggaga gctgaggtgt ccctcccctg ctagtcacct accaggtgtc tgagcagctg   3780
 catgctccct ggctcaagtg ggcactgtac cttttgcctg cctttttgtt ccctatctcc   3840
 actccctgag gccacttagc ctgagacatg atgcaagagc tgcaggccgg ggggctcagt   3900
 gccatggaag ctactccaag ttgcattgcc tcccgcgccc agatcctgct ttccatttcg   3960
 agaacataaa tagattgccc agcccctcca gtacaatccc actggaagaa aaggcaatgg   4020
 cgggcttcag ccagacctgc tgagacctag gttgccacgg taacagccaa agacatcaac   4080
 ccaagtgctg ggtcaagtgt ctcatcatac tggcactgtt gctggggtga cggcagaatt   4140
 cagaacttca atttcagtga cgccaagctt gatgtgtttc tgttattgtt ttgaagaagg   4200
 tagctcttgt ggaggacttg ggagaaggat ggggtcttag gaaggaggtg acagcacttg   4260
 catggtcact tgagcccaca cacacgctca accccaagtc ctttatgctt tgtcacagtg   4320
 aagatgagac ctctgacgtc caagccttgt tcctgtgctg catcacccac tcagccttcc   4380
 aaagggaaca ggaacaaatt tccccagcac cactgtttgg gtcccgcttt tcctatcttc   4440
 tgctgcccct gagcacatcc aagcagacag ggaaagagga gtcagacatg gcccagtcac   4500
 atcctgagct gctcctggct gataaccacg atggagcccg tgtttgtcct gccatctggc   4560
 actgcactga gtgtggcaca ggcaccgtcc tgttgatctc acaacacagt tctaagttag   4620
 gacgttcttg gctccgttag acaggtgagg aaactggggc acagagaggt gatgtcatct   4680
 gcctggtgtc aatcagctag caagtgatgg agcccagatt tcaaaccaaa gggggttacg   4740
 tccaggggct gagttcccac tcacctgtgt agagtgccat ctgggcacca ttgctccaga   4800
 cgtgttccga cccctttccc agcccacagg gcttgaagtg aaggaacaga ggcagggggt   4860
 gggccagccc cagggccagg gtccccttgg tgaagccgtg ccagggggct cagctgcttc   4920
 agggaatgtg tccctcccac catgggccag agcttcagcc cttctttagc tcagctagag   4980
 ttcacaggag agccaaaaaa gaaaaggaag ctgagcatct cccgagtcct gggcagggaa   5040
 ggggagggaa attgctgctt ctccaactct tgcttggggc caagccctgc accagttgct   5100
 tcccagctgt tatctgccag atcttcccat cttgtggcat gtggtgcccc caccaacatc   5160
 ccaaggggac caatcccctt gccaccactt tgcatcacct gggaccacag atttggacag   5220
 gaagggctct gagaagaggc caaagccctc attttacaga tgaggaagct gaagcccggg   5280
 gaggggagcg accctcaagg ccacccagct ggacacggga gacttgagcc cagccttctg   5340
 actgcattca gccctctcta ggacgcagca gcctctcccc agcactgagt cccccctccc   5400
 tttgtgtgtc ccagcaccct tggcctgagt aaacttggaa aggggctccc tcccagagaa   5460
 gggactactc tcttcacccc tttattccag ctgccctggc caccccagac ccccacctcc   5520
 caccctgacc cccgacccct gggtggggaa ggggctcaca tgggccccag gcctgaagtg   5580
 tgaagtgaag catgtccaag ttgtctgaac actgtgacat tagtgcaccc ctactgaaca   5640
 acccctcccc agccttgccc ctttctcctc tccctgtttt gtacataaat tgacatgagc   5700
 tgcaacatgt gtgcgtgtgt gtgcgtgtgt gtgtgtgtgt atgtgtgtgg tgcatctgtg   5760
 tcaatggttt tgttaccttt ttgtttttgt aaacttgaat gcttcaaaat aaacatgctg   5820
 tttactctga                                                          5830



      <210> 1632
      <211> 5729
      <212> DNA
      <213> Homo sapiens


      <400> 1632
 gcttcatgac agatgttaac agctggctgc tcacctttgg attccagcta cacaacgtga     60
 tccctggtta tcccaaacca gacatggatg ccatggaacc ctcctacgag cttatccaca    120
 cacagatgaa aacgcaggag tgggacaaca gcaagtctat cctcggggta cagtgtgaag    180
 tacagaagca gctcaaggcc tttgtcacct tagaacggtt tgaccagctc tatggctcca    240
 caatcaccag ctgccagcag gctccaaaga ccaagaagtt tgcatccagc ggctcagtct    300
 ttggcaaggg ggtcaagttt gccttgaagg atggccgagt gaccacagac atcatcagtg    360
 tggccaatga ggatgggcga agggttgctg ccatcttgaa ccatgcccac tacctagaga    420
 acctgcactt caccattgat ggggtggata cccattactt tgtgaaacca ggaccttcag    480
 aaggtgacct ggccatcctg ggcctcagtg gggggcggcg aaccctggag aatggggtca    540
 acgtcactgt gtcccagatc aacacagtac ttaatggcag gactagacgc tacacagaca    600
 tccagctcca gtacggggca ctgtgcttga acacacgcta cgggacaacg ttggatgagg    660
 agaaggcacg ggtcctggag ctgtcccggc agagagccgt gcgccaagcg tgggcccgcg    720
 agcagcagag actgcgggaa ggggaggaag gcctgcgggc ctggacagag ggggagaagc    780
 agcaggtgct gagcacaggg cgggtgcaag gctacgacgg ctttttcgtg atctctgtcg    840
 agcagtaccc agaactgtca gacagcgcca acaacatcca cttcatgaga cagagcgaga    900
 tgggccggag gtgacagaga ggaccaagga cttcttgcca aagacagcta ctcttttgtg    960
 gccgcatacc tgactgtgtt gtacttttaa aaaaatgatt ttttaacaag tgcagaaaca   1020
 aaaagatact ggttgcattg taactcatgc aacatccttt tttttagaaa agaaaaacac   1080
 agatttggcc ttcgcacatt ttttgcaaag aacagaaggt atttttttct gttagtgtga   1140
 tcacaatgaa aactttattg gtcttttgtt ccctttttcc ttgaggattt ttcccttgtc   1200
 gtttggggta tgtatctcct ctctgagatg catctcctgg gttgtgtcct cgtctgtccc   1260
 taggtaccca gtgtgatgtg ggacatgaat gtctgtgcta acttgtctca tgtgcaaccc   1320
 tttcttcttc gactggggtc gggcaggagt aaagggagtg atgggccagt acaacacccc   1380
 ttccaagggg gcctgggagg agggtctgta ggacctgagg ctccttggca gggctcctgc   1440
 agaagagtgg tggatttctt ctcaccttgt tctctgcctc cagaggatca tagatggctt   1500
 catcttgctc cagggaattt catggtgttg ttcagcacct tttttaagct gccccaaact   1560
 cctgttcaag ctttctattt tgatgctgaa tgaaaccccc taccactttt gcaaatcctg   1620
 tgtagttgtc ggtgccaccc ccatgctggg atagagaaag tgtctcccag gtcctttccc   1680
 ccagaccagt gacataacat cctgggctca gagtcccatc ctcccgggag ggaaagcacc   1740
 caggatgcct gtgattggtt ggtcctccat gatgttcctg ttcatctcct cccttctccc   1800
 aaagccagat gtgagaacga gcactgcaca gcaagccttc aatgtgggca ccatgtccac   1860
 agaacagaag gccacccatg gcaaaggcat ggcagtggtg gcgagggcac cagcctgcct   1920
 tccgaggcaa agccctctct ctatgacttt gagtatcttc cctccaccac tcagccgcca   1980
 ccactgagac gtaggaatgt ggagggaggt gcttggtggc ctttgattct ggaaaaatgc   2040
 ttaacaaaaa aagccagcca aagagaggaa ggcataagct aagcatcctt ctaaccagtt   2100
 cccaaagtcc catctgcctc catgtaccag ctgatcgcag agctggactg gggcaggctg   2160
 ggcttccagg aaattcctga agttctgaaa cagcttcccc tctagagaag cccacccaat   2220
 gtgtttttta gtgacaggaa gaaaggaggg aagagctgat gtggtgtggc ctgcccatat   2280
 catacaaccc caccaggagc agggcagttc ccaaggtggg tgcccgtaga tctgggaggc   2340
 caggctggca tgattcctgt gaagaactgt gcctgtgtcg tcagggagag gcctgagccc   2400
 tctcagaagc agggacagcc cacacctgaa gagcacgccc aagctgaggc agcagccagc   2460
 aggctggggg agcagtgagg gcagggggag tcacagccag agctgggagc cccttgttca   2520
 aggattccat tcctggttca tccgcctaat taccattgtc attaccactc acaggaggct   2580
 ctgggagatg ggaggggaag ccaaatgctt ccttttaagc tgggcttctt agaaaatgga   2640
 acttttatgg gttacattta cattaagtgt ggaaaatgaa ttctgagtct gagctattcc   2700
 ccgtggaaaa ccttgttgga ctgataagct catggcacct ctatagcctt actcacatag   2760
 tcttcagaat attacacaag ttaatgaaac tgagaaggtc tgactgcatg aggatcggag   2820
 cagcatgtag tctgggttct gcctggcaga gggaggcaac caaaacttct tggggagaag   2880
 agatttcgcc ttaacgtcat cccactggga ttagaggatg tgtttcgcta agtgctcttc   2940
 ctgtttccaa aaaaaaaagc caccctgctg cagcagtgcg ctttggcctg cttgtccact   3000
 ggttgcccat tgcccctgga tccagagctt tactgagtca gatacagtgc tctgcaggcc   3060
 tgctgtggga ggcatgagct ggagatgggg gctcccatct ggcaggatca ttcttggatg   3120
 agaatggaaa acagtttggc ctgaagaaca caagttttgt cctccagaag ggacttacgc   3180
 ctctcaaaat gtactcttca taccaagggc ccttgggcaa agtgctcctg cccagttgat   3240
 cagtcccatc ctggctgcct gacatcagtg aagacctgct ggggatgtct gctcagaggt   3300
 caggaacggc atgcggtcca caggaaccag ctccctacgc ttcccccacg ccctgtccct   3360
 cctccacagc cccctcccca aaggaatagg gtggactttt agggatcaaa aacagaatta   3420
 ttgggtgttt catttctttt tttctttctt tctttttttt ttcatagaga tggggtctca   3480
 ctatgttgcc caggctgttc tcaaactcct ggcctcaggc gatccacctt ggcctcctga   3540
 agtgctgggg ttacaggtgt gagccactgc gcctggactg agtgtttgtt tctttaaagg   3600
 atcttatatt tttcctgtgc tacataccac cacagcagcc cagcttctgt ggggagagaa   3660
 gttgaaggat cccgaagctt tagaaaaagg atctcagctg tggcacaggc agtgttatgc   3720
 gcctcactgc cacattggtg ctgttgtatt gaaggtggtg cttctggcct tggccctttt   3780
 gagttggttt ccatttgggc tgcaggtgac tcagtgactc cctcctcaag ctgtcctcct   3840
 gctaagacca gcagtcacaa acccatggca agggtgagtg tgaaggccta accctgtgcc   3900
 tatgtaatag gctccaagca tcgactccca tcctgagagg accggccctt ttgacactca   3960
 ccaaccaaat ctgttcattc gatagagtga ccaggcctcc ctcacctgcc caggtgtatg   4020
 atcctacagt tcctgccttc tctcctaccc cgcacagctg ccaactggtc ctacatcctc   4080
 agcccctctg ccaccacctt aaataggact ttaactgatt ccccaacttt gtttttttgt   4140
 aggatgagat ttccttttta tcccaccccc ccacacccca aacagaacat tgctggaggg   4200
 cagactggag gaaggggaag gcatgcaggt aaattactgc cttgtcagcc tctgaccctc   4260
 atctctcaga attgttggct gagaattaac ccaaggacca caccagtgcc tgatttctac   4320
 ttagggagag aggattggaa acgatcccta agaaactgac tgagggtgag aatggccagg   4380
 aggtgtgtgt ccaaataacc aggagggggc acagaagatg attgcaagcc agaattggca   4440
 attttttttt ggacacagaa caaagaatca gaatttgaaa aaagaagaaa aacaaatctt   4500
 cgcagctgca actttaaagt atcaccttta tagatggcag ggatttccat tatgcaaatg   4560
 gaatctaaga tttcaatgtg aaatcttaga atgcagtttt accacttgca gtcttgtatt   4620
 tgtggtggcc atgtggtgag ggcggtgatg ctgagctttc tgcccaggag gaatgagctt   4680
 tcaagctctc agcagggtgt caggcttggg gatttgacgc atccactgct caaagtccag   4740
 gctattctcc agctctcacg gcagccacta agcccaggag ccagacctgg cccagggaca   4800
 catctcctga gggatcccag aaagaaccca gtctttcctt tcccttgggg ttccttgtta   4860
 gaatgaaaac ctctctattt aaggcacatc attcccagct aggtttatac acttgtctat   4920
 attttactgg aggaaaggga attaaaaaag aactctggca gttcaaggcc cttttcattt   4980
 aaaccttcca aaaacaggca aactcatttt taaaaggatt cattgctgag gtgataggag   5040
 aggaaacctt atcctctcca accttttaca ttcacaaaaa ccatccttgt gtacttgact   5100
 gccctagaca gtggtgactc ttaggtttca ttaccgaatg tggaatatca gagtgtggga   5160
 aggcccaggc gagggccaat gttgtgtttc ttaccccctc tgggaatgcc aaaggcaagg   5220
 tactaggtga cctcctggtc ccccaaaaaa atgtgattta ttctggaggg cgaacagcca   5280
 aagggaggac tagtctggag cacgctcggc cgtcctggca ggagctgagc ctcaggtgct   5340
 ctggcggtgc cccagcagcc ctggattcac cccaacacca gaatcccact tttctaaatc   5400
 ccacctgttg ttctgagcac ctctgaaccc gcagcttcgg caaaaggagt ctgtacccaa   5460
 gctgcttctg gatgaccaac actggagact ctggccttac catgtggaaa tcattttcct   5520
 gaagtctgga actaatcttt gagaagtttc tctctcaaca cttttgtgtt tctcaacact   5580
 gtatcttgac tgtgtaaata ccaacaaggc cgtaaataaa tgcagatgta gataccttct   5640
 agaaaaaaaa aagcataaaa acaaaaccag aagtgatccc gtgtagcctt cgttgacaaa   5700
 taaagactat tttgtgttta aaaaaaaaa                                     5729



      <210> 1633
      <211> 1324
      <212> DNA
      <213> Homo sapiens


      <400> 1633
 cgattccgga gagggagcct gagaaacggc taccacatcc aaggaaggca gcaagcgcgc     60
 aaattaccca ctcccgaccc ggggaggtag tgacgaaaaa taacaataca ggactctttc    120
 gaggccctgt aattggaatg agtccacttt aaatccttta acgaggatcc attggagggc    180
 aagtctggtg ccagcagccg cggtaattcc agctccaata gcgtatatta aagttgctgc    240
 agttaaaaag ctcgtagttg gatcttggga gcgggcgggc ggtccgccgc gaggcgagcc    300
 accgcccgtc cccgcccctt gcctctcggc gccccctcga tgctcttagc tgagtgtccc    360
 gcggggcccg aagcgtttac tttgaaaaaa ttagagtgtt caaagcaggc ccgagccgcc    420
 tggataccgc agctaggaat aatggaatag gaccgcggtt ctattttgtt ggttttcgga    480
 actgaggcca tgattaagag ggacggccgg gggcattcgt attgcgccgc tagaggtgaa    540
 attcttggac cggcgcaaga cggaccagag cgaaagcatt tgccaagaat gttttcatta    600
 atcaagaacg aaagtcggag gttcgaagac gatcagatac cgtcgtagtt ccgaccataa    660
 acgatgccga ccggcgatgc ggcggcgtta ttcccatgac ccgccgggca gcttccggga    720
 aaccaaagtc tttgggttcc ggggggagta tggttgcaaa gctgaaactt aaaggaattg    780
 acggaagggc accaccagga gtggagcctg cggcttaatt tgacccaaca cgggaaacct    840
 cacccggccc ggacacggac aggattgaca gattgatagc tctttctcga ttccgtgggt    900
 ggtggtgcat ggccgttctt agttggtgga gcgatttgtc tggttaattc cgataacgaa    960
 cgagactctg gcatgctaac tagttacgcg acccccgagc aggagaacag cactgtaggc   1020
 atgaagatcc aggaggagct gcaacgttcc gggggcctgg accacctcgt actctcacca   1080
 ggagaatggc ccgtgagtga caacaccatc atgcacatcg caaccgccga ggccctcacc   1140
 acagactact ggtgcctgga tgatctgtac cgggagatgg tgagatgcta tgtggaaatc   1200
 gttgagaagc ttccagaacg ccggccagac ccagctacca ttgaaggctg tgctcagcta   1260
 aagcccaata actaccttct cgcctggcac acaccgttca atgaaaaagg ctcagggttt   1320
 ggag                                                                1324



      <210> 1634
      <211> 318
      <212> DNA
      <213> Homo sapiens


      <400> 1634
 ggcacgagcg agatgtcctc ttcaacctgt gtgaaaacct ggtgaagtcc agtgaggcaa     60
 actctccagc ccatgaggag ttcaagacga tgctgctgat cgctcattac tatgccacgc    120
 gctctgcagc cgagagtgtc tatcagctgt aagccgtgta ttgctatcct tagtgtatta    180
 gactaagcat atttcggtcg tcggtcggtt tatgtagtaa gtggtgtctt agtgcgtgtg    240
 atccgatgac cgattttttc tatcggtgtg gcatgttcta tattcgtaaa cggctggagt    300
 atatgcattt aggatgtt                                                  318



      <210> 1635
      <211> 492
      <212> DNA
      <213> Homo sapiens


      <400> 1635
 aaaatcaaag caaagaatct cacaaactat gatctctgca gcatttttct tggaacctct     60
 acgctcttgg tttgggttgg agtcatcaga tacctgggtt atttccaggc atataatgtg    120
 ctgattttaa caatgcaggc ctcactgcca aaagttcttc ggttttgtgc ttgtgctggt    180
 atgatttatc tgggttacac attctgtggc tggattgtct taggaccata ccatgacaag    240
 tttgaaaatc tgaacacagt tgctgagtgt ctgttttctc tggtcaacgg tgatgacatg    300
 tttgcaacct ttgcccaaat ccagcagaag agcatcttgg tgtggctgtt cagtcgtctg    360
 tatttatatt ccttcatcag cctttttata tatatgattc tcagtctttt tattgcactt    420
 attacagatt cttatgacac cattaagaaa ttccaacaga atgggtttcc tgaaacggat    480
 ttgcaggaat tc                                                        492



      <210> 1636
      <211> 492
      <212> DNA
      <213> Homo sapiens


      <400> 1636
 aaaatcaaag caaagaatct cacaaactat gatctctgca gcatttttct tggaacctct     60
 acgctcttgg tttgggttgg agtcatcaga tacctgggtt atttccaggc atataatgtg    120
 ctgattttaa caatgcaggc ctcactgcca aaagttcttc ggttttgtgc ttgtgctggt    180
 atgatttatc tgggttacac attctgtggc tggattgtct taggaccata ccatgacaag    240
 tttgaaaatc tgaacacagt tgctgagtgt ctgttttctc tggtcaacgg tgatgacatg    300
 tttgcaacct ttgcccaaat ccagcagaag agcatcttgg tgtggctgtt cagtcgtctg    360
 tatttatatt ccttcatcag cctttttata tatatgattc tcagtctttt tattgcactt    420
 attacagatt cttatgacac cattaagaaa ttccaacaga atgggtttcc tgaaacggat    480
 ttgcaggaat tc                                                        492



      <210> 1637
      <211> 688
      <212> DNA
      <213> Homo sapiens


      <400> 1637
 ccgtgtgggg aattccacca ctcctcccaa aagctacccc ggctgaagaa gtggaagact     60
 ccaatgactc atcatattca gagcccccag atgttcagca gcagttgaac cactatcagt    120
 cagctgccct ggcaaggaac aacagccgtg ttagccctgt gcctctttct ggggctgctg    180
 ctggcactga gcagaaaact gaagccgtgc ttcactgcga attctgtgaa ttctcctccg    240
 gctacatcca gagcatcagg cgtcattacc gggacaagca tggtgggaag aagcttttca    300
 agtgcaaaga ctgctccttt tacacaggct ttaaatctgc ttttactatg cacgtggaag    360
 ctgggcactc agcagttccc gaggagggcc ccaaagatct tcgctgtcct ctctgcctct    420
 atcacaccaa atacaagcgc aacatgattg accacatcgt gctgcaccga gaagagcgtg    480
 ttgtccccat tgaagtttgc cggtccaaac tgtccaaata cttgcaggga gtagttttcc    540
 gctgtgataa gtgtaccttc acctgctcca ggtgatgaga gcctccagca acatatagaa    600
 aagcacaatg aactgaaacc ttacaaatgc cagctctgct actatgagac caagcacacg    660
 gaggaactgg acagccacct tcgggatg                                       688



      <210> 1638
      <211> 472
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(472)
      <223> n = a,t,c or g


      <400> 1638
 tggggangnn nnnaatcgag atccatagcc cgtgtggtgg aattctttct ctgctgtgga     60
 tgccactttt ggaatacgcc aggaacatgc taaggacctg gagctctcta ccctggaccc    120
 gttttcgggt ttgcttgctc tctctctctc tctttctctg ggctaatcgt ttagaggaca    180
 gtcgctcctg ccaacctaat cccatgagcc tgactacctt gccgggccac aggctcaaag    240
 aagcagtgtg gctgccagca ccctcacgca ccatgagtcc tcaccttgac cctaatcaac    300
 ttgggattct cctcagagta cttagaaagg aaaaggaaga cggtgactac cctgacatga    360
 tggccaccca cccgagctcc aggtatgaag cctgctcctc tggaattact ctagcggccc    420
 cgccgaccca cggcccacga cccaccgacc cacgaatcgg cccggccccc gn            472



      <210> 1639
      <211> 472
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(472)
      <223> n = a,t,c or g


      <400> 1639
 tggggangnn nnnaatcgag atccatagcc cgtgtggtgg aattctttct ctgctgtgga     60
 tgccactttt ggaatacgcc aggaacatgc taaggacctg gagctctcta ccctggaccc    120
 gttttcgggt ttgcttgctc tctctctctc tctttctctg ggctaatcgt ttagaggaca    180
 gtcgctcctg ccaacctaat cccatgagcc tgactacctt gccgggccac aggctcaaag    240
 aagcagtgtg gctgccagca ccctcacgca ccatgagtcc tcaccttgac cctaatcaac    300
 ttgggattct cctcagagta cttagaaagg aaaaggaaga cggtgactac cctgacatga    360
 tggccaccca cccgagctcc aggtatgaag cctgctcctc tggaattact ctagcggccc    420
 cgccgaccca cggcccacga cccaccgacc cacgaatcgg cccggccccc gn            472



      <210> 1640
      <211> 443
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(443)
      <223> n = a,t,c or g


      <400> 1640
 attgaatagc actacnccag ngcggnggaa ttctggagga cttcctgagg aatcaccatt     60
 atgcagtcag caggaagcac tccagctctg gggtggtggc cagcgagtct ctgaccaact    120
 acctggatgt ctccaacatt gtggaccccc accagactgt gggtctgagc acccaggaac    180
 ctggcgacat cttcacctac tccgagtttg atgggatcct ggggctggcc tatccctctc    240
 ttgcctctga gtagtcagtg ccagtgcttg acaacacgat gcagaggcac ctggtggccc    300
 aagacctgtt ctcagtctac atgagcaggc tccctgcact ggatacccat gactgcaaga    360
 atactggcag ttcactgtgg acaggtgggt gagcggccac actgtgtggg cctcagccag    420
 aggctgatcc agctgtgggg atg                                            443



      <210> 1641
      <211> 502
      <212> DNA
      <213> Homo sapiens


      <400> 1641
 tttcgtggcc gggctgcggc tgaggcggcg gcggcgcccc gcttctgttg aggttgccgg     60
 ggccgcgcgc gctgatctgc gagtgaagag ggacgaggga aaagaaacaa agccacagac    120
 gcaacttgag actcccgcat cccaaaagaa gcaccagatc agcaaaaaaa gaagatgggc    180
 cccccgagcc tcgtgctgtg cttgctgtcc gcaactgtgt tctccctgct gggtggaagc    240
 tcggccttcc tgtcgcacca ccgcctgaaa ggcaggtttc agagggaccg caggaacatc    300
 cgccccaaca tcatcctggt gctgacggac gaccaggatg tggagctggg ttccatgcag    360
 gtgatgaaca agacccggcg catcatggag cagggcgggg cgcacttcat caacgccttc    420
 gtgaccacac ccatgtgctg cccctcacgc tcctccatcc tcactggcaa gtacgtccac    480
 aaccacaaca cctacatgta tt                                             502



      <210> 1642
      <211> 498
      <212> DNA
      <213> Homo sapiens


      <400> 1642
 agtacaagga agtggtgaca cagcatttcc tatgagtgac ctatgagacc caccccatat     60
 attatctgaa gatcagccaa ccatctggta atcccaagaa aatcatttgg atggactgtg    120
 gaattcacgc cagagaatgg attgctcctg ctttttgcca atggttcgtc aaagaaattc    180
 tacaaaacca taaagacaac tcaaggatac gcaagctcct tatgaacctg gacttctatg    240
 tccttccagt tcttaacata gatggttata tctacacttg gacaactgat cgtctttgga    300
 ggaaatcccg ttcaccccat aataatggca catgttttgg gacggatctc aatcgaaatt    360
 tcaatgcttc ttggtgtagt attggtgcct ctagaaactg ccaagatcaa acattctgtg    420
 ggacagggcc agtgtctgaa ccagagacta aagctgttgc cagcttcata gagagcaaga    480
 atgatgattt ttgtgctt                                                  498



      <210> 1643
      <211> 498
      <212> DNA
      <213> Homo sapiens


      <400> 1643
 agtacaagga agtggtgaca cagcatttcc tatgagtgac ctatgagacc caccccatat     60
 attatctgaa gatcagccaa ccatctggta atcccaagaa aatcatttgg atggactgtg    120
 gaattcacgc cagagaatgg attgctcctg ctttttgcca atggttcgtc aaagaaattc    180
 tacaaaacca taaagacaac tcaaggatac gcaagctcct tatgaacctg gacttctatg    240
 tccttccagt tcttaacata gatggttata tctacacttg gacaactgat cgtctttgga    300
 ggaaatcccg ttcaccccat aataatggca catgttttgg gacggatctc aatcgaaatt    360
 tcaatgcttc ttggtgtagt attggtgcct ctagaaactg ccaagatcaa acattctgtg    420
 ggacagggcc agtgtctgaa ccagagacta aagctgttgc cagcttcata gagagcaaga    480
 atgatgattt ttgtgctt                                                  498



      <210> 1644
      <211> 970
      <212> DNA
      <213> Homo sapiens


      <400> 1644
 tttttttttt ttcatcttcc attattttat tattttttat acatatatat atatgcgcag     60
 atctgtttta tgtacaacaa ttggttctat caaatattca gaccaaggca ttctactggt    120
 aatttccccc caaatcaatt caggtaaaat tagatactta tgcacttcac gggctatcaa    180
 aacttgcaac ttcattatca atttcagttc tgaggtcata cacacaattc aaaatataca    240
 ttaactaggt taaggcgata aaagtgggct gaaagaaacc acaggattca gaacaatgaa    300
 actgtgtatt ttgcttgcat gagagtcata acgtgaacag caagtattgt gcgtatctca    360
 tagctcttca gtggagagga agcggcttct gaacatctaa ggtgactgca cagcaggtgg    420
 gaaacagctg gtgtggcctg ctggaggctt cgccgaggga gggctcattt cttctctgcc    480
 tctccttttt tgggttcttg tttcaatttg taatcagcca gggcggcctt gattgcatct    540
 tcagccagca tggagcagtg cagtttcacg ggaggaaggc agagctcctt ggcgatatct    600
 gtgtttttga tagtcaaggc ttcctccacc gtctttcctt tcacccattc agtggctaat    660
 gagctggagg caattgcgga accacagcca aatgttttaa acctagcatc cacaatcttc    720
 cccttttcat ccacttgaat ctgtaatttc attacgtcac cacatgctgg agcccccacc    780
 agtccagttc caacattttt agatgtcttg tcaagggacc ccacgtttct aggattttca    840
 taatgatcaa caaccttctt gtgatagagt cgggccgggg ccgacagctc ccgggcgggc    900
 aggcgggggc tccgcagcag cagagccgat gccacccgcc tcagacggcc agccccagcc    960
 gccgccatct                                                           970



      <210> 1645
      <211> 1192
      <212> DNA
      <213> Homo sapiens


      <400> 1645
 tttgagatgg agtctcactc tgccaccagg ctggaatgca gtggcgcgat cttgggtgac     60
 agagcaagat tctgtctaaa aaaaaagaaa gaaataggag caggatcaac ttccagatat    120
 acagagaata taaaaataca ttcactttat tttagaaaaa tgaagactca tagagtaagc    180
 ttatcacaaa ctggcctatt aggagtcaca gaattcacag gaaacaattt ctgaagacca    240
 ggtgcctgct gccacctctc caagcaggcc agagtccagt agagaatgcg attcaggaag    300
 atggctcctc agagggcagg gaggttagct acggaggccg ctcacatgga aatgtccagt    360
 gaaccaatgc caaggaagaa gataaaaatt ctctggggct gaccacaaca gtgggggtgg    420
 ataaagacaa accacttgcc tgtacttctc atcttctatt tgttcatttc actgctggaa    480
 ggtgacctct tttcccctaa tcttctttca acccagagag tttaagtctt ctccagctca    540
 atcctaatcc accccatttc ccatggtctc tactcctggg agaccagccc tggtggcatc    600
 tcttcctcct gtccctgggc cagaatctgc tggagtcagg gtctgctggg tagaggcgag    660
 tccaggtact gactgtagtg gtttgctact gaagtcttgc ttgctgtcct gatctcttta    720
 cctggtaggt cctgggactg ccactttcct ggggggctgc agattgctgc gagtggcacc    780
 catgacagga agatttagtc gctgggaaac aggaaccttg tgtccacttt cccgcactct    840
 gtgtcctgca gtgcttggtc ttggaagccc ttttcgagtt gacagagaat ccggaggtag    900
 ggcacctctg ccaggtggca cactccggct ggtgagtggc attcggctgg caggcccgca    960
 acttggctgc tctggtctcc tcactggctg ctgctctccc actgggcccg gctctccccc   1020
 ggactggggg agtcgatcgg gtaagaggag aagatgctgg gcttttggat gcagggaaca   1080
 gattgcaagt gggtgactcc ctcttcatgt tggagggcct ctttccagat gtagccggag   1140
 agccctgact gaccccttcc tatctttctc cgccctcgtc caagcttgcg ta           1192



      <210> 1646
      <211> 918
      <212> DNA
      <213> Homo sapiens


      <400> 1646
 gcagcttgga gatgtcgtcg gatggggaac ccctgagccg catggactcg gaggacagca     60
 taagcagtac tataatggat gtagacagca caatttccag tgggcgttca actccagcaa    120
 tgatgaatgg acaaggaagc actacttctt caagcaaaaa tattgcctat aattgttgtt    180
 gggaccagtg ccaggcttgc ttcaactcta gcccagatct ggcagatcac atccgttcca    240
 tacatgtaga tggtcagcga ggaggggtat ttgtttgctt atggaaaggt tgtaaagtat    300
 ataacactcc atctaccagt caaagttggt tacaaaggca tatgctgaca cacagtggag    360
 acaaaccttt caagtgtgtt gttggtggct gcaatgccag ctttgcttct cagggagggc    420
 tagctcgtca tgtacccaca cacttcagtc agcagaactc ctcaaaagtt tctagccagc    480
 caaaggccaa agaagaatct ccttctaaag ctggaatgaa caaaaggagg aaattaaaga    540
 acaaaagacg acgctcatta gcacggccac atgatttctt cgatgcacaa acactggatg    600
 cgataagaca tcgagccata tgctttaacc tctcagctca tatagaaagt ttagggaagg    660
 gacacagtgt tgtttttcat agtactgtaa gtattctttt attttttcaa attaaatata    720
 aaactttgca aaaaaatatt tccacaatca tttctaaatc tctcaaaatc taagaaagta    780
 caatttaaca gaaatcacaa aaccttttgt tttatcagta tttaaaacat tgtattattg    840
 gttataaagc acacatttct tataatttta catgtttgtg attaaactga atatgttagc    900
 ctttagtttg agttactt                                                  918



      <210> 1647
      <211> 4707
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(4707)
      <223> n = a,t,c or g


      <400> 1647
 tttttttttt ttctgggttc cgataaaact ttatttggcc tgacctgatc aagtttaata     60
 atgtttaata aattttttaa aaacattagt agttataaca attcctctgt aataacagtt    120
 atatatgaac tcctggtcaa ggccagcagc ttgttccttt accaaaaaag taaagccgcc    180
 ctctgaggac aaaatggcac atgaggagtg gtgtacattt ctttttctta aagaaaaaac    240
 aaaacccaaa cacttcctat ttacatattt tccatttaaa agttggtcag tgtgattaat    300
 tctgttttta aatataagtt tctaatgtgt tgcaggtttc aacgtacaaa ttatagtttg    360
 ctgattagat ttaaggtgct gtgatgtgag ggtgaacgca gcccaagacc aactggtgga    420
 atcctctacc tggaaactgg ctggacttcc tgtgggtatc tttgggagtg ttgggggaag    480
 agaaggagct gaacaccagt ggcagaaatg gtagaatgtt cctggggacc agataggggc    540
 tgtcagtgtc cccaccccac gcttctgcag agggcctgtg tctacacacc attaccccat    600
 gctctgtggg tgagcacaca ggtttgcatg caccaaactc accttagcct acactatgag    660
 gggcattgct gctttgagtc ccttcctttg tcatgaggtc tccatgctgg tgcctgaccc    720
 ctaagagccc ttgctgttga cacctctctt ttcatatctt cctacctttc tggattcctt    780
 gcccccaagg tcacgacgtg ctctccaaca catctctgta gggtctgctg tttgtcaagg    840
 ctaaatggat gatcaaactc aggaaagtat tgatgaagga tgttgggtcc catgtgaaac    900
 cttctctcct aacacatttg ctctatggca ggacctcact gctgtcctcc aaatgagcag    960
 ttcatgtaga gaacattagg tcccgaggta ggtctggaga ggcgctgtgg ttaggtgggg   1020
 gggccgggtg tggggtgaag ggggagtgct ggcagggagg ttggagggat tcttggaatt   1080
 ggtgccttca acctcactgg ggtaggacgc ccagtgggga aagagggctg tgtctttgcg   1140
 tgtcaggaaa gtgcataggg agtgctgagg gggtgtgtgc acaggcctgg gagaagggct   1200
 gattttaccc acagacccca ggctgttctg acctgaaacg aagatttccg accatgcagg   1260
 ggtgaggcaa atacaggggt gcgacagatg agaacattta agtacttggg gagccaggaa   1320
 agtatgcttg gtgactagga gaaacaaact ggttcagttt ccagtttcag aatacaagaa   1380
 acattgcttt gaataaaaga acatcgaatg gtaatggaca gggaagaaac atctcagacc   1440
 aagtttctaa caaaaagcca gaacgacccc agtagaggaa gacattctat ggtggacaga   1500
 ccctggcctg ggggccagga gactgggatt tcaagctcgt cctcacacta agcctgtgat   1560
 cttaagcgag tgtctctgcc tctctgggcc taattgcctt tcctcagctg tcagttgagg   1620
 ctagttgggc cagatggttt cggagctacc tctgcaagat ttctcggcat cctgccaccc   1680
 aggtggggcc cgcagactgc tgtctaaagc cgtttcttcc ctgtgcacca catgtggtct   1740
 cccctttgct aggaaaatga tcaaccccta agccagggtc ctgttcaaac ccgctcccac   1800
 aggttaaagg ctagttatta aggcagttta agaaatggac attcctctcg ctcctcggat   1860
 ccttcacgtg ttctgccaac cccaaggcag cagagagggc ggaggcggcc gcctcctgcc   1920
 agccccggct ttctctgggg gtctcctgct ctgtggggcc tggagcggcc cctccgccct   1980
 caccaccttt ctttggagaa ggcctcggtc tgcacgaggt cgccagggtg ctcggggatg   2040
 cacgcaccat tgaggtcgcc cagtttattg tccggcaggt cctcgggctt ggtgcagagc   2100
 ttcagggcgc gggagatgaa cacgtccagg tcgaactggg ggctggcgcc cgncgtccac   2160
 cggggccggg cggccggggg gcgaggcaga caagcggcgc tcggcgtcgt cggcgggcgg   2220
 gctggcgtgc tctgggccgc cctgcgtgct cttgacccac tgcgcgatcc tccaggaaga   2280
 ggctggccgg ctcgtcctcg cgcgcccccg tgtccgccag cccccgtggc cgtggggggc   2340
 gcgccggccg cctgcttcca gtgcgacagg tccaggatga gcttgggctc cgagtagtgg   2400
 tgcggcttgt tgtcgcgcca cagcagcttg tccaggtagg acggcgaccc caccttgtag   2460
 tcgcaggagc gcccgtagtc ggcctcgaag gcgcgctcca tggacgagtg cgactgctct   2520
 aggaagcgct cggagctgct gtgcgagtcc ttgcgcgggt ccacctgcac gttctcagcc   2580
 agtggcgccg aacccgcgcg cgggtcgcgc tgtacctcgc tggcgtcctg gcaccggtca   2640
 ggccgccact ccaggtccga cgacaggctc acagggtacc tggaactgca cgtgtcccag   2700
 ttggacagct ggctctggtt agcggccatc agcacgatgt cgtcgatctc atcctcaatg   2760
 cggaaggggt gttgtgaggt gggctcgtcc tcagggcacg agtatgggct catgtagggg   2820
 tgttgcagcc ccatctcagc tgttaggcga tccatggggt taaaggtcag gatcttctcc   2880
 agaaagtcga tggcttcact gttcacttca gggagcagct tgcgcagagg cctcttcacc   2940
 tcccaggtgc tgctgacaaa ggaaggcatc accctgagca gctcgtcctt gtcttcctcc   3000
 cggattacag ggatggtctc caggatgagt tgcatctgct ccagctcatg ggccccagca   3060
 aagagcattc tccccgtaag catctcagcc aggatgcagc cggcggccca catgtcgatg   3120
 gctttggtgt agttattggg ggaaaggagc agtcgtgggg aacggtacca ctttgttacc   3180
 aacccttctg acagataacc cttgttggga gtaatgctga tcaacgatcc ttgccaaccc   3240
 gaaatcccca atcttgagca cgaggtcctc tgtgctgatg aagatgttgg cgggcttcag   3300
 gtccctgtgc agcacgttgg cggagtggat gtacttgagc ccgcggagca gctggtacat   3360
 gaacagcttg gcatgctctt ctgccagcgt gccctgctcc agcaggcgtg ccaggtcggt   3420
 ctccatgtac tcctggacga tgtacgccac gctgaacttg aacagctcac cctgcaggtc   3480
 agtgcccttg ggaccgagca cctcgtacac tttgacgatg ttgtcgtggt ccaggcgccg   3540
 aatgatcttg atctctcgga gcgcgtgctt catgctgcgg gcatcgctca gggcaatctt   3600
 cttcacagcg accttccggc aggcccggct gtccacggcc gacagcacca aaccattgac   3660
 accgaagccc aggggttgga agtcaacaaa gcgcccaccg aggtcatacc catagacact   3720
 ggcgatgcag tcacccttct cagccattgt gggctcagtg atctggagct gcccaggtaa   3780
 cacaggggca gtcaggaaag gccaagtctc ggctagcggc ctccctcgcg cacctcattc   3840
 tgtcaagtcc cacggctgag ggatgtgttt tctcctagtg aggtcactgc caccagctct   3900
 ctggagacga gaatggcata tggtcatgct cgctgagctg tgctagttgg gggcgcaggc   3960
 tgtcgtctta acctgcattg ggagggctgt ctactaattc ctgtgtttcc tgaacccttc   4020
 ttaaagctta gaatggctca tatttctttt aaagctggca tcttggaaag aaaacccagt   4080
 atcattatct atggaatgtc aagttttcta ccatagtgga ctgcaaagta aaagatgcag   4140
 aaactctccc ctttggaata ctttgttaca agaggctctt tctgggctga aatgcaagag   4200
 tttgttttgc tggagctgga gctccttaaa atgctccaaa agctcagctg tgtcacagcc   4260
 tctgtctgtg ttcccaagca gttatgccag ggatccccat caatggaatt ctgggaaggc   4320
 atccccaggg gcttctttcc taccctctcc ctgtttccta cccagctcac ccttagaatt   4380
 cccaaaacct gagcccagtc tggtaaggca ctggtgaaaa aaagctggag aaacacaagc   4440
 acctttcatg agctctacac ccaagttacg cctgaggttc ccaaatgcag gggagctcag   4500
 ctgcccaggc ccaggatcct ctggagcctt tggatgtggg cagcatcctc tttcaccagc   4560
 tcatccacgc cacctcgccc aagactgtat tccactgcac caagagaggc tgcaggaatg   4620
 tggcatcttt cagaccaagt ctccttcccg aggcagagcc cgagagcgtg gcggcccggg   4680
 cgcgagccgc cctttgtctg cggccgc                                       4707



      <210> 1648
      <211> 1513
      <212> DNA
      <213> Homo sapiens


      <400> 1648
 cttttttttt tatcattgat aggactaaac tgtcttcaac ttactaactg gagtttcttt     60
 acccagcagt tcagagcagt gagaactaca gaaggcgagg aggagacaga gagcaggtaa    120
 cggggcttta ccgtgacagc agtgcgttcc cctgctccac actcccactg actcagtctt    180
 gccaatgcca ctatcaaggt ccttgcaaaa atctggtttt cttttgtctg gaaagggctg    240
 gttttctcct ctgaaactga accccaactg ttggccctat ttaaatctca ggtcttggat    300
 ttcttactta cataagcagg ggcttaggta atagagtggg ttgtgcctgt ggagcctccc    360
 aatcagctct caacctcctc tgttggcagg gtccccggca gcacacggcc acagcgctcc    420
 ttcctctcaa gggtggtccg ggcagcccta cccctgcagc tgctcctcct gctgctgctg    480
 ctcctggcct gcctgctgcc ctcctccgaa gaagactaca gctgcactca ggccaacaac    540
 tttgcccggt ccttttaccc catgctgagg tacaccaatg ggccaccccc cacatagagg    600
 gcatagctgg ccacagtgct acaccacctg cctgattgcc aagggtgccc agcacgtggc    660
 cccagaccaa tctgagtgac ttagtgttgg caaggtcccg ggacctgtgc agacttcttc    720
 tgggcttacc cagcacgggc tccctggagc ccagggcagc tttcagattg tgttcctccc    780
 caggagcagg gaacctgtgt ggcaggtgcc ccgggtattt tggcagaact agttgattag    840
 tttagggatc tctggaaatg tcagtttcct gaagagccaa gcactttgtg aattctggtt    900
 tgtttgtaaa acagcattat tataatgtag gtatggtcaa tgagcagtgg tgtccatcac    960
 atatattata gaagcaagcg aggacattcc accctagaaa tggttcagaa actcataggc   1020
 acccttagct gatggaaaca atcaatcata tttaatacgc ttagaatcag ttttactcca   1080
 atcagctggc aattttgagc tgccggttat acaccaaaat gttctgttca gtacctagct   1140
 ctgctctttt atattgcttt aaatttttaa agaaattgta ttgcatggat gtggttattt   1200
 gtgcatattt tttaacaatg cccaatctgt atgaataatg taaacttcga ttttttttta   1260
 aaaaaattag attttagctg gagcttttga ctaatgtaaa gtaaatgcca aactaccgac   1320
 ttgataggga tgtttttgta agttaatttt ctaagacttt ttcacatcca aagtgatgct   1380
 ttgctttggg ttttaactgt ttggccacgg cgggggtggg ggcggggggt tggtacaaaa   1440
 acttgaagct gtttgtgata tgtacaactc agatgtttct cattaaaaaa caaaattagc   1500
 cagaaaaaaa aaa                                                      1513



      <210> 1649
      <211> 811
      <212> DNA
      <213> Homo sapiens


      <400> 1649
 gctcgacttt tttttttttt gagaatttaa aatcttattt attgttttgc aaacaataac     60
 ttagacattt cttaatattt taaaaacccc aacacaaagt aataaatttg gcttcttttc    120
 cccacaaaaa tgggaaatac ctttcagtaa aggaaatttt aaattatttt tacacaccag    180
 ttggttgttg gaatttatag ctctttaaca tatgacatca gcaaaaataa ttagcattaa    240
 ctgattaata cataaaacaa tttacaatca tatggtaagc aggaaacaaa aaccgaccag    300
 aaaacaccgt tttatagtaa ttttcaaaca gataaattat tacagtatac tttatcccca    360
 acatctctga gcccattaat agagtacttc tatacatata aagatataat aaaaggatac    420
 ggtatttatt gcaacagcaa attaaaggtt gttaaaatat atgtaactta aatacccccc    480
 caacattgat atagtggctt cttattcctt aaacatagaa attccactct tcattgtaga    540
 aagataaagt tctttcatca aaaggcacat tcttatcttc gaggatgatt ggcatcaaac    600
 aacgtgttgt catcatcctc atcatcctgt tctaaaggtg tcaattccat attttctatg    660
 ttagtgtcca aaactccata tctcctagtc tttcggtttc ttcttctcat cctgaccgtc    720
 ctgaccacga agtacaccag caccgcgccg ctcaccacca tcaacacggt cagggcccgc    780
 tgggtcatgg gcttgtcgcc agggttgggg c                                   811



      <210> 1650
      <211> 443
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(443)
      <223> n = a,t,c or g


      <400> 1650
 ntcgtagttc ctagtccatg tggtggaatt ctgggcggcg gngccggggt aggtggcgat     60
 tccgagggtg aagtgaccag tgcgctgagc gccaccttca gcggccccaa gatcgccttc    120
 tatgtgggtc tcaagagccc ccacgaaggc tatgaggtgc tgaagttcga tgacgtggtc    180
 accaacctcg gcaatcacta tgaccccacc acgggcaagt tcagctgcca ggtacgcggc    240
 atctacttct tcacctacca catcctcatg cgcggcggcg acggcaccag catgtgggcg    300
 gacctctgca agaacgggca ggtccgggcc agcgccattg cacaggacgc cgaccagaac    360
 tacgactacg ccagtaacag cgtggtgctg cacttggatt caggggacga agtgtatgtg    420
 aagctggatg gcgggaaggc tca                                            443



      <210> 1651
      <211> 997
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(997)
      <223> n = a,t,c or g


      <400> 1651
 ttttgtgaga cgaccacttt attaaatcac caggggttca aaacatttga aaagaaaact     60
 atgactggga aattactggt gtgtgtccga caccggggct ttgggtgggt taagggtttg    120
 ctttgaagct caccgagaac ttcaacatgg gcttttcccg gggcctcagg aggcaaatgg    180
 agctggggaa accccggagc cgaaggcggt tcactccccc gtcggggacg atggtgagcc    240
 tggcgtgagt gatgacatct tggagctcta gggtcaggct atcgaacaga tgactttggt    300
 tgggagacaa cttggtcact ggaagcagtg gtttccactt gtgggccggg agaatccact    360
 tttgcctgat cacggcttct tcctgagttg tcaggatgca cccatccact ttacagctgt    420
 caggagcatt gccttcaaaa tattttgtgt caatttcaat tcgagttatt actccaggat    480
 gtgccaatcg gaaaactgcc cattcacaac ccggaaccaa gagaatgcca ttctcatcat    540
 tttctaatat tggtggccgg tccagccttc ttgcagtttc ccaaccatcc gccatagact    600
 ttgccccgcc aactcctatt atattgtttg ggtgcccaaa cttagcatta ctaaatccta    660
 cacagacacc cccaaaagcg atggccacta ggtctgcagg ttctttgggg tcagttgcag    720
 tccagtcttt ttgtccagta ccgaatacta taagtcgtgc aattccacca tctgtgttgt    780
 tcacttctgt accactcttg tatcgtctct acctagaaga ggtctgggca catagtaggc    840
 attgaagttt ttttcattaa atgaacaact ccaaggtcaa acagcattcg ggaaattcac    900
 catacagata atgtttcgtg ctagaaataa gcatcgctga ctcccacaca gacgaattcc    960
 acggcatatg cgcngctaac tgggtnannn acccgcc                             997



      <210> 1652
      <211> 1875
      <212> DNA
      <213> Homo sapiens


      <400> 1652
 tcaggctgcc tgatctgccc agctttccag ctttcctctg gattccggcc tctggtcatc     60
 cctccccacc ctctctccaa ggccctctcc tggtctccct tcttctagaa ccccttcctc    120
 cacctccctc tctgcagaac ttctccttta ccccccaccc cccaccactg ccccctttcc    180
 ttttctgacc tccttttgga gggctcagcg ctgcccagac cataggagag atgtgggagg    240
 ctcagttcct gggcttgctg tttctgcagc cgctttgggt ggctccagtg aagcctctcc    300
 agccaggggc tgaggtcccg gtggtgtggg cccaggaggg ggctcctgcc cagctcccct    360
 gcagccccac aatccccctc caggatctca gccttctgcg aagagcaggg gtcacttggc    420
 agcatcagcc agacagtggc ccgcccgctg ccgcccccgg ccatcccctg gcccccggcc    480
 ctcacccggc ggcgccctcc tcctgggggc ccaggccccg ccgctacacg gtgctgagcg    540
 tgggtcccgg aggcctgcgc agcgggaggc tgcccctgca gccccgcgtc cagctggatg    600
 agcgcggccg gcagcgcggg gacttctcgc tatggctgcg cccagcccgg cgcgcggacg    660
 ccggcgagta ccgcgccgcg gtgcacctca gggaccgcgc cctctcctgc cgcctccgtc    720
 tgcgcctggg ccaggcctcg atgactgcca gccccccagg atctctcaga gcctccgact    780
 gggtcatttt gaactgctcc ttcagccgcc ctgaccgccc agcctctgtg cattggttcc    840
 ggaaccgggg ccagggccga gtccctgtcc gggagtcccc ccatcaccac ttagcggaaa    900
 gcttcctctt cctgccccaa gtcagcccca tggactctgg gccctggggc tgcatcctca    960
 cctacagaga tggcttcaac gtctccatca tgtataacct cactgttctg ggtctggagc   1020
 ccccaactcc cttgacagtg tacgctggag caggttccag ggtggggctg ccctgccgcc   1080
 tgcctgctgg tgtggggacc cggtctttcc tcactgccaa gtggactcct cctgggggag   1140
 gccctgacct cctggtgact ggagacaatg gcgactttac ccttcgacta gaggatgtga   1200
 gccaggccca ggctgggacc tacacctgcc atatccatct gcaggaacag cagctcaatg   1260
 ccactgtcac attggcaatc atcacagtga ctcccaaatc ctttgggtca cctggatccc   1320
 tggggaagct gctttgtgag gtgactccag tatctggaca agaacgcttt gtgtggagct   1380
 ctctggacac cccatcccag aggagtttct caggaccttg gctggaggca caggaggccc   1440
 agctcctttc ccagccttgg caatgccagc tgtaccaggg ggagaggctt cttggagcag   1500
 cagtgtactt cacagagctg tctagcccag gtgcccaacg ctctgggaga gccccaggtg   1560
 ccctcccagc aggccacctc ctgctgtttc tcacccttgg tgtcctttct ctgctccttt   1620
 tggtgactgg cacctttggc tttcaccttt ggagaagaca gtgccgaccc aagacgattt   1680
 tctgccttag agcaagggat tcacaccttc gccaggctca gagcaagata gaggagctgg   1740
 agcaagaacc ggagccggag ccggagccgg aaccggagcc cgagcccgag cccgagccgg   1800
 agcagctctg acctggagct gaggcagcca gcagatctca gcagcccagt ccaaataaac   1860
 gtcctgtcta gcagc                                                    1875



      <210> 1653
      <211> 3773
      <212> DNA
      <213> Homo sapiens


      <400> 1653
 tttcgtggcc gcgaggcagg ggtgagaccg gcggccaccc gggagccctc cgcacccgca     60
 ccatgcagaa gagcgtgcgc tacaacgagg ggcacgccct gtacctggcc tttctggcgc    120
 gcaaggaggg caccaagcgc ggcttcctga gtaagaagac ggccgaggcg agccgctggc    180
 acgagaagtg gttcgccctc taccagaatg tgctcttcta cttcgagggc gagcagagct    240
 gccgcccggc gggcatgtac ctcctggagg gctgcagctg cgaacgaacg cccgcgccac    300
 ccagggccgg cgccgggcag ggaggcgtcc gagacgcgct ggacaagcag tattacttta    360
 ctgttctttt tggccatgaa ggtcagaagc cactggagct gcgctgtgag gaggagcagg    420
 atggtaaaga gtggatggag gccattcacc aagccagtta tgcagacatt ttgattgaga    480
 gggaagtatt aatgcagaag tacattcatc tagttcagat cgtagagaca gaaaaaattg    540
 cagctaacca actccgacat caacttgaag atcaagacac agaaatcgaa aggcttaaat    600
 cagagattat tgctcttaat aaaaccaaag aacgaatgcg accttaccaa agcaaccaag    660
 aagacgaaga tccagacatc aagaagatta aaaaggttca gagcttcatg cgaggatggt    720
 tgtgcagaag gaaatggaag accatcgtgc aggattacat ttgttctcct catgctgaaa    780
 gtatgaggaa gagaaaccag attgtgttca ccatggtgga ggcagagtca gagtacgttc    840
 accagctcta catcctggtc aatggctttc tccggcccct gcgtatggcc gccagctcca    900
 agaagccccc catcagccac gacgacgtca gcagtatttt tcttaacagt gaaacaatca    960
 tgtttcttca tgaaatattt catcaaggac taaaggcaag gatagcaaac tggcccactt   1020
 taattttagc tgatctgttt gatattttgc tccccatgct gaacatttat caagaatttg   1080
 tgcgtaatca ccagtacagc ctgcaagttc tcgccaattg taagcaaaac agagattttg   1140
 acaaactctt aaaacagtat gaagccaatc cagcctgtga ggggaggatg ctggagacat   1200
 tcttgaccta tcccatgttt cagatcccca gatatatcat cacactccat gagctccttg   1260
 ctcacacacc ccatgagcat gtggaaagga aaagcctgga gtttgccaaa tcaaagctag   1320
 aggaactatc cagagtaatg cacgatgaag tcagcgacac tgaaaacata aggaaaaacc   1380
 ttgccatcga aagaatgatc gtggagggct gtgacatctt gctggacacc agccaaacgt   1440
 tcatccgcca aggttctctt attcaagtac cttccgttga gagggggaaa cttagtaaag   1500
 ttcgcctggg ttcgttgtct ttgaaaaagg aaggagagag acaatgcttc ttatttacaa   1560
 aacacttttt aatatgtaca agaagttcag gagggaagct tcatctgctc aagacaggtg   1620
 gggttctgtc tctaatagac tgcacattga ttgaggagcc agatgcaagc gatgatgact   1680
 ctaaaggttc tgggcaagtg tttgggcacc tggattttaa aatagtggtg gagcctcctg   1740
 accgtgccgc cttcactgtt gtcttgttag caccctcacg ccaggagaaa gctgcctgga   1800
 tgagtgacat cagtcagtgt gtggacaata tacgatgtaa tggtttaatg actatagtgt   1860
 ttgaagagaa ttccaaagtc actgtgccac atatgattaa gtctgatgcc cgtcttcata   1920
 aagacgacac tgacatttgc ttcagtaaaa cactcaactc ctgcaaagtg ccccagatcc   1980
 gttatgccag cgtggagcgc ctcttggaac gactgacaga cttgcggttt cttagtattg   2040
 atttcctcaa cacctttctg cacacctatc gtattttcac tactgccgct gtggtgctgg   2100
 ggaaactctc cgacatatac aagaggcctt tcacctccat ccctgtcagg tcattggaat   2160
 tgttttttgc taccagccag aacaacagag gtgaacattt ggtggatggc aaatccccac   2220
 gtctgtgtcg caaattctct tccccgccac cactggctgt gtccagaaca tcttccccag   2280
 tgagggccag aaagctgtct ttgacttctc ccttgaactc aaagatagga gcattggacc   2340
 tgacaacttc cagcagtccc accaccacca cccagagtcc cgctgcgtct ccaccaccac   2400
 acactggtca gataccactg gatctcagca gaggcctctc ttctccagag caaagcccgg   2460
 gaacggtaga agagaatgtc gataacccac gcgtggatct gtgtaacaag ctaaaacgaa   2520
 gcattcaaaa agcagtccta gagtctgcac cagcggaccg agcaggagtg gaaagctccc   2580
 ctgcagcgga caccacagaa ctttcacctt gcagatcccc ctcaactcct cggcacctcc   2640
 gctatcgaca gcctggagga cagacggcgg acaatgccca ctgctctgtt tcaccggctt   2700
 ctgcttttgc aatagccaca gctgcagcag gacatgggag tccaccaggc tttaacaaca   2760
 ccgagagaac atgtgataaa gagtttatta tacggagaac ggctaccaat cgagttctga   2820
 acgtcctccg tcactgggtc tcaaagcacg cacaggattt cgaactcaac aatgaactaa   2880
 agatgaatgt cctaaatttg ctagaagaag ttttgcgaga cccagacctt cttccccaag   2940
 aaaggaaagc cgccgcgaat atcctcatgg ccctttcaca agatgaccaa gatgacatcc   3000
 acctaaaatt agaggatata attcaaatga ctgactgcat gaaggccgaa tgctttgagt   3060
 ccttgtcggc catggagctg gcagaacaga tcaccctcct ggaccatgtc attttcagaa   3120
 gcattcccta cgaggagttt cttgggcagg ggtggatgaa gctggataaa aacgaaagaa   3180
 ctccttacat tatgaaaacc agccaacact tcaatgacat gagtaacctg gtggcctccc   3240
 agataatgaa ctatgctgat gtcagctccc gtgccaacgc catcgagaaa tgggtggcag   3300
 tggcggacat ctgccgatgc ctgcacaact acaacggcgt gctggagatc acctcggcct   3360
 taaacagaag tgccatctac aggctgaaga aaacctgggc caaggtctct aagcagacaa   3420
 aagctctaat ggacaaactt caaaagactg tttcctctga aggaagattt aaaaatctta   3480
 gagaaaccct taaaaattgt aaccctcctg cagttcctta tcttgggatg tacttgacag   3540
 acctggcatt tattgaagaa ggaacaccaa actttactga ggaaggcctt gtcaatttct   3600
 ccaaaatgag aatgatatca cacatcatca gagagatacg ccagttccag cagacttcct   3660
 acagaataga tcatcagcca aaggtcgcac agtacttgct tgacaaagac cttatcatag   3720
 atgaagatac gctatatgag ctgtcactca aaattgaacc tcgactccct gct          3773



      <210> 1654
      <211> 4602
      <212> DNA
      <213> Homo sapiens


      <400> 1654
 gcatctggaa atcttgacaa aaatgccaga ttttctgcca tctacaggca agacagcaat     60
 aagctatcca atgatgacat gctcaagtta cttgcagact ttcggaaacc tgagaagatg    120
 gctaagctcc cagtgatttt aggcaatcta gacattacaa ttgataatgt ttcctcagac    180
 ttccctaatt atgttaattc atcatacatt cccacaaaac aatttgaaac ctgcagtaaa    240
 actcccatca cgtttgaagt ggaggaattt gtgccctgca taccaaaaca cactcagcct    300
 tacaccatct acaccaatca cctttacgtt tatcctaagt acttgaaata cgacagtcag    360
 aagtcttttg ccaaggctag aaatattgcg atttgcattg aattcaaaga ttcagatgag    420
 gaagactctc agccccttaa gtgcatttat ggcagacctg gtgggccagt tttcacaaga    480
 agcgcctttg ctgcagtttt acaccatcac caaaacccag aattttatga tgagattaaa    540
 atagagttgc ccactcagct gcatgaaaag caccacctgt tgctcacatt cttccatgtc    600
 agctgtgaca actcaagtaa aggaagcacg aagaagaggg atgtcgttga aacccaagtt    660
 ggctactcct ggcttcccct cctgaaagac ggaagggtgg tgacaagcga gcagcacatc    720
 ccggtctcgg cgaaccttcc ttcgggctat cttggctacc aggagcttgg gatgggcagg    780
 cattatggtc cggaaattaa atgggtagat ggaggcaagc cactgctgaa aatttccact    840
 catctggttt ctacagtgta tactcaggat cagcatttac ataatttttt ccagtactgt    900
 cagaaaaccg aatctggagc ccaagcctta ggaaacgaac ttgtaaagta ccttaagagt    960
 ctgcatgcga tggaaggcca cgtgatgatc gccttcttgc ccactatcct aaaccagctg   1020
 ttccgagtcc tcaccagagc cacacaggaa gaagtcgcgg ttaacgtgac tcgggtcatt   1080
 attcatgtgg ttgcccagtg ccatgaggaa ggattggaga gccacttgag gtcatatgtt   1140
 aagtacgcgt ataaggctga gccatatgtt gcctctgaat acaagacagt gcatgaagaa   1200
 ctgaccaaat ccatgaccac gattctcaag ccttctgccg atttcctcac cagcaacaaa   1260
 ctactgaagt actcatggtt tttctttgat gtactgatca aatctatggc tcagcatttg   1320
 atagagaact ccaaagttaa gttgctgcga aaccagagat ttcctgcatc ctatcatcat   1380
 gcagtggaaa ccgttgtaaa tatgctgatg ccacacatca ctcagaagtt tcgagataat   1440
 ccagaggcat ctaagaacgc gaatcatagc cttgctgtct tcatcaagag atgtttcacc   1500
 ttcatggaca ggggctttgt cttcaagcag atcaacaact acattagctg ttttgctcct   1560
 ggagacccaa agaccctctt tgaatacaag tttgaatttc tccgtgtagt gtgcaaccat   1620
 gaacattata ttccgttgaa cttaccaatg ccatttggaa aaggcaggat tcaaagatac   1680
 caagacctcc agcttgacta ctcattaaca gatgagttct gcagaaacca cttcttggtg   1740
 ggactgttac tgagggaggt ggggacagcc ctccaggagt tccgggaggt ccgtctgatc   1800
 gccatcagtg tgctcaagaa cctgctgata aagcattctt ttgatgacag atatgcttca   1860
 aggagccatc aggcaaggat agccaccctc tacctgcctc tgtttggtct gctgattgaa   1920
 aacgtccagc ggatcaatgt gagggatgtg tcacccttcc ctgtgaacgc gggcatgact   1980
 gtgaaggatg aatccctggc tctaccagct gtgaatccgc tggtgacgcc gcagaaggga   2040
 agcaccctgg acaacagcct gcacaaggac ctgctgggcg ccatctccgg cattgcttct   2100
 ccatatacaa cctcaactcc aaacatcaac agtgtgagaa atgctgattc gagaggatct   2160
 ctcataagca cagattcggg taacagcctt ccagaaagga atagtgagaa gagcaattcc   2220
 ctggataagc accaacaaag tagcacattg ggaaattccg tggttcgctg tgataaactt   2280
 gaccagtctg agattaagag cctactgatg tgtttcctct acatcttaaa gagcatgtct   2340
 gatgatgctt tgtttacata ttggaacaag gcttcaacat ctgaacttat ggattttttt   2400
 acaatatctg aagtctgcct gcaccagttc cagtacatgg ggaagcgata catagccaga   2460
 acaggaatga tgcatgccag attgcagcag ctgggcagcc tggataactc tctcactttt   2520
 aaccacagct atggccactc ggacgcagat gttctgcacc agtcattact tgaagccaac   2580
 attgctactg aggtttgcct gacagctctg gacacgcttt ctctatttac attggcgttt   2640
 aagaaccagc tcctggccga ccatggacat aatcctctca tgaaaaaagt ttttgatgtc   2700
 tacctgtgtt ttcttcaaaa acatcagtct gaaacggctt taaaaaatgt cttcactgcc   2760
 ttaaggtcct taatttataa gtttccctca acattctatg aagggagagc ggacatgtgt   2820
 gcggctctgt gttacgagat tctcaagtgc tgtaactcca agctgagctc catcaggacg   2880
 gaggcctccc agctgctcta cttcctgatg aggaacaact ttgattacac tggaaagaag   2940
 tcctttgtcc ggacacattt gcaagtcatc atatctgtca gccagctgat agcagacgtt   3000
 gttggcattg ggggaaccag attccagcag tccctgtcca tcatcaacaa ctgtgccaac   3060
 agtgaccggc ttattaagca caccagcttc tcctctgatg tgaaggactt aaccaaaagg   3120
 atacgcacgg tgctaatggc caccgcccag atgaaggagc atgagaacga cccagagatg   3180
 ctggtggacc tccagtacag cctggccaaa tcctatgcca gcacgcccga gctcaggaag   3240
 acgtggctcg acagcatggc caggatccat gtcaaaaatg gcgatctctc agaggcagca   3300
 atgtgctatg tccacgtaac agccctagtg gcagaatatc tcacacggaa agaagcagtc   3360
 cagtgggagc cgccccttct cccccacagc catagcgcct gcctgaggag gagccgggga   3420
 ggcgtgttta gacaaggatg caccgccttc agggtcatta ccccaaacat cgacgaggag   3480
 gcctccatga tggaagacgt ggggatgcag gatgtccatt tcaacgagga tgtgctgatg   3540
 gagctccttg agcagtgcgc agatggactc tggaaagccg agcgctacga gctcattgcc   3600
 gacatctaca aacttatcat ccccatttat gagaagcgga gggattttga gaggctggcc   3660
 catctgtatg acacgctgca ccgggcctac agcaaagtga ccgaggtcat gcactcgggc   3720
 cgcaggcttc tggggaccta cttccgggta gccttcttcg ggcaggcagc gcaataccag   3780
 tttacagaca gtgaaacaga tgtggaggga ttctttgaag atgaagatgg aaaggagtat   3840
 atttacaagg aacccaaact cacaccgctg tcggaaattt ctcagagact ccttaaactg   3900
 tactcggata aatttggttc tgaaaatgtc aaaatgatac aggattctgg caaggtcaac   3960
 cctaaggatc tggattctaa gtatgcctac atccaggtga ctcacgtcat ccccttcttt   4020
 gacgaaaaag agttgcaaga aaggaaaaca gagtttgaga gatcccacaa catccgccgc   4080
 ttcatgtttg agatgccatt tacgcagacc gggaagaggc agggcggggt ggaagagcag   4140
 tgcaaacggc gcaccatcct gacagccata cactgcttcc cttatgtgaa gaagcgcatc   4200
 cctgtcatgt accagcacca cactgacctg aaccccatcg aggtggccat tgacgagatg   4260
 agtaagaagg tggcggagct ccggcagctg tgctcctcgg ccgaggtgga catgatcaaa   4320
 ctgcagctca aactccaggg cagcgtgagt gttcaggtca atgctggccc actagcatat   4380
 gcgcgagctt tcttagatga tacaaacaca aagcgatatc ctgacaataa agtgaagctg   4440
 cttaaggaag ttttcaggca atttgtggaa gcttgcggtc aagccttagc ggtaaacgaa   4500
 cgtctgatta aagaagacca gctcgagtat caggaagaaa tgaaagccaa ctacagggaa   4560
 atggcgaagg agctttctga aatcatgcat gagcagctgg ga                      4602



      <210> 1655
      <211> 1587
      <212> DNA
      <213> Homo sapiens


      <400> 1655
 atgaggatgg aggccgggga ggcagcgccg ccggcggggg cgggcggccg cgccgcaggc     60
 ggctggggca agtgggtgcg gctcaacgtg gggggcacgg tgttcctgac cacccggcag    120
 acgctgtgcc gcgagcagaa gtccttcctc agccgcctgt gccaggggga agagctgcag    180
 tcggaccggg atgagaccgg ggcctacctc attgaccgtg accccaccta cttcgggccc    240
 atcctgaact tcctccggca tggcaagctg gtgctggaca aggacatggc tgaggagggg    300
 gtcctggagg aagccgagtt ctacaacatc ggcccgctga tccgcatcat caaagaccgg    360
 atggaagaga aggactacac ggtcacccag gtcccaccca agcatgtgta ccgcgtgctg    420
 cagtgccagg aggaggagct cacgcaaatg gtctccacca tgtctgatgg ctggcgcttc    480
 gagcagctgg tgaacatcgg ctcctcctac aactacggca gcgaggacca ggcagagttc    540
 ctgtgtgtgg tgtccaagga gctccacagc accccaaacg ggctgagctc agagtccagc    600
 cgcaaaacca agagcacgga ggagcagctg gaggagcagc agcagcagga ggaggaggtg    660
 gaggaggtgg aggtggaaca ggtgcaggtg gaggcagatg cacaggagaa agctgttaca    720
 agccagaggc acccggatgt gaggccccag atcacctcca gggacttggg gttcccatct    780
 gaaatccttt atttttgtac catggggtgg gccccgggcc tgagaaggaa gaagcaccct    840
 ctccccggcc tcctctgtct gcacccgtgg ggctgtgact tactcctgcc tccaggggcg    900
 gggcggggcc cccctgggac ctcttaaggc ccaaggtggg ccccaggacc tctgggcaga    960
 gtggactgct catggcagat gtgtggcaat gtctggctgt gtctctccgg cacctgcgtc   1020
 ccctctcccg ggctcccctg ctgcatggtg gatgtgctcc ttcctggccc ggtcacattg   1080
 cctccttgag ccttagtcca gggggtcact cctcccaccc cacctacctc acagggttgt   1140
 tgtgagggtg cacagaggag caaagtccct gaaggccctc aggcagtata taggggccgc   1200
 ccaccttcag ctgccctggg atgggaagga cccagcccga cccctgggca taacactgtg   1260
 tttgcaaatg gagattcagg tattggggat gcaggttgtg gggagctggc ctggcagagt   1320
 aggggtagtt ggcttggcct tctctttggt gatcccaccc ccagccattt gcattgctgg   1380
 cccagcgcct ggcctggggg gcggggagag gcagcagaag gggctgggca ggggcggtgg   1440
 aggactcagg aactgcccgg ggagagtggg tatggcggct gagccagggg ccctcctgtg   1500
 tttgacttcc cgggatgggt ccttgcttct cagctgtgtc cgaccccacc atgtaataaa   1560
 acccaaagga acagcccaaa aaaaaaa                                       1587



      <210> 1656
      <211> 2793
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2793)
      <223> n = a,t,c or g


      <400> 1656
 tttttttttt ttgtcatact aaatatttat tttctgcaga ctgacttcgg agtaattctt     60
 gagccaggag gggagaggtt agtgttcaaa ttgctgagat cttaggtcaa aaagctacag    120
 aaaagaaatc actttgaaaa acacaatgac tcagaggcag tcaccccttg ccagcaattc    180
 caagagctga ggaggcttca tgcctcagga catggtgact agttgagtga accagagatt    240
 gaggcagtgg tttttacagg ggaagaaaca agccttgggt gtatgggagc aggaaaggag    300
 ggtgacagac tggagaaatg ataaaggcca ttttggaagc ccacagggaa gtggtcttgg    360
 gaaacctgaa gacactggga tattcagaag gccaagggga tccagcttat cctgttgggc    420
 aaggtgctgg gagtgaaggc aggtaagcca tgtcaagggc ctgggaagca aggggaaaac    480
 tggaaggggt accccaggtg aagaagggta tggaatgggg tgcagaagtc catggagatg    540
 accggcagat ctcagggcgg tttctggcac atcagaagtt gggcttatgc ttcttgagct    600
 ccaccataag gtggtgaatg ttgatgagct cagcccgggc agggagggct cggagctgcg    660
 gctgggacag gcacccggtg gaagcgatga tagaggctgg atcagctggg tcagcgctcc    720
 ctgaatgata ctggtgccat ttctgaagtt ggtgaaactc cgcattacat cctgactcag    780
 agattccact gatgatttcc aggaactacc aaagccacgg atcagctgag ttacccgggc    840
 ttcttcccct cgaagtcgct cagcctgtcc acgctcaatc aaagcctcag cctccttcac    900
 aaatgccact aaacccccaa aagggggaga cagcaactct tcaatgaatt cctgtgtccg    960
 agcattgagc agctgctgga agctctcaac ctctttgctg tcatctgcag cccgctccta   1020
 ttaccatcag cacacccagc atcatgtcat agttgttgat cagaaacaca agctgctcct   1080
 tccttgagga gaactcagct gccactcgga ggacaaaatt ctccacctcc acctgcagct   1140
 gtcccagcaa ttgcatggtc cgttcattag gaattgtctg gttgatactg acaagagcgg   1200
 aggagaactc tgcatagcgg cgtgtgatat agtggggccg agtatccaac ccccctaggc   1260
 gctgggggtc agtgcttcgg acgctctgaa cattcatctc caggatcagt tcaaaccgtg   1320
 gccatagcaa ggcaagcacc tgttcccagt acctgtccag ggcaggaaca tccctctttg   1380
 ctgcaatgtt acggaaccgg agaacaatgt ggatacagag aaaaacagca atggcatcgt   1440
 agcagtcagc tagataagaa tccaggtgtt tcagggtcat gctgagtgta cggcccatga   1500
 cagcatggaa caggtcgtgt gcagctgggc cagacacaac aaaaaattca cagatgaaaa   1560
 ggtattcgcg gcaggaattg tctaggaggg cgtagtgctg gctgcggaag agggcctcaa   1620
 atggatacct ctgctctccg cgctgcgctg tgtgaggcac caggatgggg gcctcaagtt   1680
 cagtggggga gatgacagag ccgcgggttc ctagggtgaa aatggtgttc ctgctgcgga   1740
 gcgatggctt tgagaagaat cctttctttg ctgtatcttc cacacccatt agatcatctt   1800
 tctcagcgac ttcctcatac tgcaccttca tgagccgccc caggtaagag cggtagtaag   1860
 acaggtaaat cttgctcagc gtctccacat attcatccct gatctccttt gctgttgctc   1920
 gttcattgcc cagcagaaac tgatagaaga acctgtactt cagcagggcc gtctggggga   1980
 tctgatagtt ggtcatgggt ttcctgaagg aataaatctt ctggaggata aactctcgga   2040
 tcttcgtcac tgccttgacc cggagccgat cgagcacgcc tctgacatct gcgcaggctg   2100
 ctgtgcctct agcttcctgc tctctgactg cggctgcctt ggcatccagc tcctgtagct   2160
 gctccaagaa cctgggctct gtcactggag cctccagaat tgccgtgacc agagcagaag   2220
 gcaccaccag accatcaaca agctccccaa gtttcccccg aactgcctgg cgatttcgaa   2280
 gtcgaatgtt catggctcct gactgttcct gcagtgtccg gatctcagag ctgatggagc   2340
 tgaggtcact ctgaaaagct cccaacatct gctccattcg ctccaggaca gcatcacagg   2400
 ctgtgatctg gttgtgtaga gatgctatat tctcactctc ttgaatataa tcccgaatgg   2460
 atttctgttc aatctgctgt agctccagct caacttgctt tgaatagtga cggagatcta   2520
 cacccatcca cttcatccag gatgaattca tcagaagtga tatccaactc cccaagttgc   2580
 agtggttcct ggagcccagg accacccgct tccggcaact gtcagtcccg gcgagtccgt   2640
 tccccggagt ggagctacaa gtcccaaagg gtcttcctca gcgcgaaatc gttcccagat   2700
 atttgagata agttgtttga ctccagctgt cccctttcag ctctaaccac tacgaaatcg   2760
 tcgacccgga aattnnnngc ggtcacagat ggg                                2793



      <210> 1657
      <211> 1212
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1212)
      <223> n = a,t,c or g


      <400> 1657
 tttttttttt tttggaaaag agaaagtaaa gatattccta attcagagcc aaaggtacac     60
 agcagctgtt ggcgggaggc cacctagaga tttatcaagg acgcgccacc ccaccaggag    120
 cccctcttga tcaccaagtg ctttatcttc caagtagtaa gtcaatcaag aggtttctaa    180
 agataatcca tttttgataa attagaatgg aaacagtgtc tctataatat acatacaaaa    240
 gtgtcccagt tttcaactgt gagcaacaca ggtgcacaga ccaggtgtca gcgcaggaac    300
 ccgacggcag gcatgctgat gccccccatt tcccgccact cccgacagct ccccgggcat    360
 ggccccgatt cccgccactc ccgacagctc cccgggcatg gccccgattc ccgccactcc    420
 cgacagctcc ccgggcatag cccgtgattg cctggcctca gccctcggcc ccctgcgtgg    480
 gcggctcctc cccggcctct ggtttcttgt gcctgcgcat gtgcctgtac ttgtccacgt    540
 acgccttcac caggttggcc accttcacgg ggttgatctc tccactcttg ctgtggcaga    600
 tcttctgcac ggccttgcgc aggatgtcct tgtactcctc cttggtcacc tccctcttct    660
 ggtagaaggg cttgatggcc agcttcacct cctccacagc acgctcctgc atgtgcagct    720
 tcttcatgta ctcctccttc ttggttttct ccgcagctag cctgggggcc ggggtcttct    780
 cctccgagtt gctggctgca gtggcttgac tggctggctc tgaggctggg gtcagggcag    840
 cgggcactgg ggccagggtc tgtgctgccc cacagcccac tagcggcagg ctcccctgaa    900
 ggatgaactg gaccgtgggc tggctgacca gtgcgcaggg tgggatgctt gagggctggg    960
 ccggggcagg cggcaggccg gggctgtaaa cctgagaggg gtctgtgtct gggaacccgg   1020
 gttccggaag cacgtgactg ggaaagggca gctcggagaa cgcctgcctg acccctgtgg   1080
 gggccacatc ctccatgtcc caggctcctt ctcggggctt ctgtggcctg tgaagtggtg   1140
 cccctggggg cccgacagac agggaggtgg gaatacggcc actcgagacg gtgatcgagg   1200
 cnnnnagctc cc                                                       1212



      <210> 1658
      <211> 1212
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1212)
      <223> n = a,t,c or g


      <400> 1658
 tttttttttt tttggaaaag agaaagtaaa gatattccta attcagagcc aaaggtacac     60
 agcagctgtt ggcgggaggc cacctagaga tttatcaagg acgcgccacc ccaccaggag    120
 cccctcttga tcaccaagtg ctttatcttc caagtagtaa gtcaatcaag aggtttctaa    180
 agataatcca tttttgataa attagaatgg aaacagtgtc tctataatat acatacaaaa    240
 gtgtcccagt tttcaactgt gagcaacaca ggtgcacaga ccaggtgtca gcgcaggaac    300
 ccgacggcag gcatgctgat gccccccatt tcccgccact cccgacagct ccccgggcat    360
 ggccccgatt cccgccactc ccgacagctc cccgggcatg gccccgattc ccgccactcc    420
 cgacagctcc ccgggcatag cccgtgattg cctggcctca gccctcggcc ccctgcgtgg    480
 gcggctcctc cccggcctct ggtttcttgt gcctgcgcat gtgcctgtac ttgtccacgt    540
 acgccttcac caggttggcc accttcacgg ggttgatctc tccactcttg ctgtggcaga    600
 tcttctgcac ggccttgcgc aggatgtcct tgtactcctc cttggtcacc tccctcttct    660
 ggtagaaggg cttgatggcc agcttcacct cctccacagc acgctcctgc atgtgcagct    720
 tcttcatgta ctcctccttc ttggttttct ccgcagctag cctgggggcc ggggtcttct    780
 cctccgagtt gctggctgca gtggcttgac tggctggctc tgaggctggg gtcagggcag    840
 cgggcactgg ggccagggtc tgtgctgccc cacagcccac tagcggcagg ctcccctgaa    900
 ggatgaactg gaccgtgggc tggctgacca gtgcgcaggg tgggatgctt gagggctggg    960
 ccggggcagg cggcaggccg gggctgtaaa cctgagaggg gtctgtgtct gggaacccgg   1020
 gttccggaag cacgtgactg ggaaagggca gctcggagaa cgcctgcctg acccctgtgg   1080
 gggccacatc ctccatgtcc caggctcctt ctcggggctt ctgtggcctg tgaagtggtg   1140
 cccctggggg cccgacagac agggaggtgg gaatacggcc actcgagacg gtgatcgagg   1200
 cnnnnagctc cc                                                       1212



      <210> 1659
      <211> 900
      <212> DNA
      <213> Homo sapiens


      <400> 1659
 ctaatacgtt gcatgcccgc gtaaacttgg gcccccccag ggatccttta aaacggccgc     60
 cccttttttt tttttttttt tctcaaatgt catttattag aaaatacaat tcccgagaaa    120
 ggagatacaa gggattctgg gaagtgggaa gtaaacagta cacagatctc tttaaatcag    180
 gagcatatag gtcataataa aatgagctac aggcacaaag ccagtaacac atttatggtc    240
 cgttcatctg gaaaagtttc accgcccact ccccactcct cttccccctc ctggaagcag    300
 ccagctttat ccttggcatt ttaattttag agaaaattta aacttccatg ctgccctgtg    360
 gcttcggtca atggagcttc tttctccagt tatggaatga gtcagcaaaa cggggagttt    420
 ctgatccttg gaattaggga gggacagttt acagaatgtc ctcatttcac tcttttccca    480
 atcatgggaa atatccagcc aattctggtt ttaaagattc atatcaaatt caaagtccct    540
 ccctcctttt ggcgaggaag acaacccttt agagcgaaac acaaaagagc aaatgtaaaa    600
 tccatctggg gcggggcatg gtggctcacg cctgtaatcc cagcactttg ggaggccaag    660
 gcaggcagat cacgaggtca agagatcgag accatcctgg ccaacatggt gaaaccccgt    720
 ctctactaaa aatacaaaaa ttagcttggc gtggtagcac atgcctgtaa tccccagcta    780
 ctcgggaggc tgaggtagga gaatcgcttg aacccgggag gcagattttg cagtgagtcg    840
 agatcatgcc actacactcc agcctggcga cagggcgaga ctccgtttcc aaaaaaaaaa    900



      <210> 1660
      <211> 3637
      <212> DNA
      <213> Homo sapiens


      <400> 1660
 agcggccgcc gcgcgccagc gggaggcgct ccctctgccc acctccgccc cctgcggacc     60
 gagacccgga gatgtcgagt tgtggagttc ggctcggccc ggcgacgggc tagctgcccg    120
 ggaacccccg cgggtggaca catgcatgcc ggagctccgg gaggggccgc gccgccaccg    180
 tctgaactag gatgtcccga catgaaggtg tcagctgtga tgcatgttta aaaggaaatt    240
 ttcgaggtcg cagatataag tgtttaattt gctacgatta cgatctttgt gcatcttgtt    300
 atgaaagtgg tgcaacaaca acaaggcata caactgacca cccaatgcag tgcatattaa    360
 caagggtaga ttttgattta tactatggtg gggaagcttt ctctgtagag cagccacagt    420
 cttttacttg tccctattgt ggaaaaatgg gctatacgga gacatctctt caagaacatg    480
 ttacttctga acatgcagaa acatcaacag aagtgatttg tccaatatgt gcagcgttac    540
 ctggaggcga tcctaatcat gtcacggatg actttgcagc tcatcttaca cttgaacaca    600
 gagcccctag agatttagat gaatcgagtg gtgttcgaca tgtacgtaga atgtttcacc    660
 ctggccgggg attaggaggt cctcgtgctc gtagatcaaa catgcacttt actagcagtt    720
 ctactggtgg actttcttct tctcagagtt catattctcc aagcaatagg gaagccatgg    780
 atcctatagc tgagctttta tctcagttat caggagtgag acgttctgca ggaggacagc    840
 ttaattcctc tggcccttcc gcttctcagt tacaacaact gcagatgcag ctgcagctag    900
 aacggcagca tgcccaggca gcacggcaac aactggagac cgcacgcaac gcaacccggc    960
 gtactaacac aagcagtgtc accactacaa tcacacaatc cacagcaaca accaacatag   1020
 ctaatacaga aagcagtcag cagactctac agaattccca gtttctttta acaaggttga   1080
 atgatcctaa aatgtctgaa acggagcgcc agtccatgga aagcgagcgt gcagaccgca   1140
 gcctgtttgt ccaagagctc cttctgtcca ctttagtgcg tgaagagagc tcatcctcag   1200
 atgaggatga tcggggggag atggcagatt ttggtgctat gggctgtgta gatattatgc   1260
 ctttagatgt tgctttagaa aacctaaatt taaaagagag taataaagga aatgagcctc   1320
 caccacctcc tctttgatga catcccaatt cgcagacaat gtcctctgtg ctgtatttgc   1380
 caatgaaagt ggacaacaac tatcttgggt ttgtttggtg attgtaattt caggtctgtc   1440
 actcttgtta cattgtgtac attcaaaagg aagagagaaa atatatatga taatcatttc   1500
 cacttaacta atttttactt ctagcaggta aatgtaggta gcagtgcagg ggtgatctct   1560
 gcttcctgta ccttgacatg caaaaggctc tcctaatact ccacattcaa actgaagagg   1620
 aaaattgaaa tctctaatga agctgctgtg tgtatttatg aatattaatg aataaaaact   1680
 gcttggatgg tttaccttaa ctactgcatg aggttttttg cagcgtgcat gagttttagt   1740
 gaccttgtta tttaagaagt taaatacaag gagtaaaact taaaaaaaaa atacaaagcc   1800
 caaagctttc ccaaacatta ttcaatggtt acacgacgaa gtaggctttt gaataatgtc   1860
 tgcctgaatc acctttcttt gtgtgcctcc tacgcacaaa gccagctctg cagtgggaat   1920
 ctgggggatt atagccgggt gtggcactcc gccctgtgtg actgtcctgt cgccctgtta   1980
 gtcatcttgc ctgtgtggag ctcagcctgt ctctttaact catctgtaga agacacacca   2040
 gtaaagctac tgttggaatc tgctgcaggg gcctttgtgt gccctaaaaa caaatcctgt   2100
 tcatgtttgt ttaaagtttt tactttttgt ggttgtttaa aattttttca attgttaaat   2160
 atgttttatt caggtgtaga tgaatttcat ttattgactg ttcaacagag ttaacctgaa   2220
 ttatgttgtc tttgttttta aaaatctcac attctcaatc atattttgca ttatttatgt   2280
 atttgctttg tagtttgctg agacagatca gtatcagggg agctttgagg atttgccttc   2340
 ccagatttgt cagtatatta caaccaaatt cttaatgcta attttagcac cttttattta   2400
 ttgggttttt tctggcataa aaagtaaagc cttttaattg aatcatgcca cctatatgcc   2460
 tatattatta atcctatgtg taaaaaaaat gtacagcttt ttttgggttt gttttggggt   2520
 ttggaagggc cgggttattt tttatttcct gtttcagttt ttgtgcatag actttcacaa   2580
 tagctccaag gcagggacag cgggtttggg ggttgggagg gcagtttttg gaatgtaaat   2640
 ttaggacttt taaaaaggtg cgcacagctt ctgataaatt tataactaga cttaacctaa   2700
 tcatgtctcg ttccagttct cttttctctg agcccttttc aaagtctcct ctctttctcc   2760
 tgtcatcctt ttcctttcct gtccgtgtat ctccgtttct tcaacatgac aagcatacag   2820
 acttgaacac ccctccggtg ttcttccgag aactgtgaag tccatgttca tccaaatgta   2880
 accaaaaaag aagtcaccct acatgtctga aaaactgttg cttctcctct gaaacttcaa   2940
 actccaacga tttccaaata caatagcttt gttttcttta gttctgtaat ggataatgtt   3000
 taaaggaaaa ctttacacca ggcttctggt tacactagaa gtcaagccca ttagggattt   3060
 tcattttttt tcatttggtt gttgagaagt ttcaaaaatc agttttcaag ctgtggtctt   3120
 tcaaacacat ctgcacataa gtcacacatt tcaataaagc attttcaaga ctgttgacca   3180
 cttgaatttc tttggtgtta gtggattaac ctaaccatta ctctgagatt ttatatctct   3240
 aatccagtat tttttttctt tttatgctaa acatgggaga tcctggtttt gtgtgaatgc   3300
 attattttgg atgtgagaaa taaatgccaa ttatatgtac tttccctttt ctgcacaaat   3360
 tctgggaaaa tgtaaaagcc ttcatttttt aacatggttt tagggaacaa ctgtaagtcc   3420
 attcagagca gtttaattta gatgatcact tttaacactg cagaagacct aaggagtcat   3480
 aagattccat ctcatgtaga atactgtata ttaattattt tttaccagat attttacaaa   3540
 tacctcacct catcctgtat gtaatcaata atgtattatt ttagggtaga acgacacaga   3600
 atatcaatat aaaaatatat tcaagccctt gaaaaaa                            3637



      <210> 1661
      <211> 1155
      <212> DNA
      <213> Homo sapiens


      <400> 1661
 ttttgctcta tgaagaaatt cactttaaca cttataactg taagactttg catacattac     60
 aacagtgcat tagtgataca agttgtaaaa tacgtttcca ttcctttgga ttttgcatat    120
 gatggttttg catcagtcac tgcaggtaga ttgagcaagc tttttgtgtt tgttttttta    180
 aacatgcatt caactagata tgattcagaa tagattaata ctcccttttt atcattacag    240
 ttagctaaaa aattgccagg gcagtccaca aaacagaatt tgctttaaga ccaacccaca    300
 gagtcagctg gagactaacg gcgctggggc ctgctgggcc gggatatagt cgtgtttagc    360
 taagtgtcga gagcattaag aagaaagtcc tggttggagg cgcaaggcct gcagcaccag    420
 ctgtggaatc cccaataatg tgactgcaca gctccgtcct caaacatttg caggtgatca    480
 ccactgaggg ggcacatagc tgtaagtggg cgttccctgg ggcccggtac gtgggcacag    540
 tgaccgggtg gggggcgaca ggagttgggg agtgagcagt cagcagggta cctgctgaca    600
 tggccatggt ggtcccagcc accatgccca tggtgacccc gttgcctcta ggagggggga    660
 tgggagcagg gtacaccgtt gcaggcatgc cgttgggctg caccaccgtg gtgtggtgga    720
 tgacgtgagg aggtgctgca tacagcggct gtgtgtagta cgtgccttgc tgtgcatacg    780
 ggctctgctg ggggtaggca cttcgcacag ggtacacggc agtctggtag gggttcgggg    840
 aggaggagta cggtggcaca gccccgctgg tgggggaaca ggacactttg taaggtgtgc    900
 caggagtgta acctgtttgg aaggtaggat tcgctccagg atacatgtta ggagaatagg    960
 caggagctgc tgctgcatag cccatgggaa aaccagctgg ataaccaatt cctttggcat   1020
 ttgcataggg aaccccagaa gatccaggac tataaacagg attcatgatt tcaaaaacct   1080
 ccgagccccg cgtctccgcc gcctcccgga cgacgaactc ccgctcgctc ggctccgctt   1140
 ggcccggcca cgaaa                                                    1155



      <210> 1662
      <211> 631
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(631)
      <223> n = a,t,c or g


      <400> 1662
 tttcgtccag cccctcgccg ggagcgggca ccatggtgct gtcggtgcct gtgatcgcgc     60
 tgggcgccac gctgggcaca gccaccagca tcctcgcgtt gtgcggggtc acctgcctgt    120
 gtcggcacat gcaccccaag aaggggctgc tgccgcggga ccaggacccc gacctggaga    180
 aggcgaagcc cagcttgctc gggtctgcac aacggttcaa tgttaaaaag tccacggaac    240
 ctgttcagcc ccgtgccctc ctcaagttcc cagacatcta tggacccagg ccagctgtga    300
 cggctccaga ggtcatcaac tatgcagact attcactgag gtctacggag gagcccactg    360
 cacctgccag cccccaaccc ccgaatgaca gtcgcctcaa gaggcaggtc acagaggagc    420
 tgttcatcct ccctcagaat ggtgtggtgg aggatgtctg tgtcatggag acctggaacc    480
 cacagaaggc tggcagttgg aaccaggccc ccaaactcca ctactgcctg gactatgact    540
 gtcataaggc agaatgtttg tgactcgcct ggaagctgtg accagcatcc acgacggatg    600
 ctgtgactgg tacgtnctaa ggaggtggcc a                                   631



      <210> 1663
      <211> 6204
      <212> DNA
      <213> Homo sapiens


      <400> 1663
 tttttttttt ttaactgatg ttttaaattt aagtcattta ttttacaaac agagactacc     60
 tattatactt aagacattgg gttagatctt tgccaaagac atggtttagt catacctaat    120
 gtaatccatt ttttaacttt ccatattaat ttaattttta attcattttt ctttatgctt    180
 gcttcagggg ctacatctgg gactgaatag cagcatatgg cccaagggct ggtgggtttt    240
 gccactcatg ctctatactt ttagtctttt ccagagttga gtatagcagt cacgtatcgt    300
 taatacaggg tgtcactatt ttattacctg gcagagaaac aggattaact tcctttattt    360
 aatactgata aatagaaagg ctttttcaag aaaaaaaaag aaagcttaca tttacaaaag    420
 tgatttatgg taatatgtgc cattaacaaa gacaaatact gaaatccaca caaaatcaga    480
 attaacttct acaactaaaa aaaaattaca gggtaataaa actgtaggaa aagctgtatg    540
 taaaaagaaa aaaagacaag tccctatgta gctaattaca agagaatatt gtaaatacat    600
 tcaaaaaagt tttccaaaaa tcctgcagcc tcatctagaa actgatacat gttaagattc    660
 ttgatctata ccaaattata atgttaaagg aaatcatgaa aactgaggta tatatttgat    720
 gcattagaaa ctatcatttg aacactattt aaatagttta attataaggt ctaatttcaa    780
 gttaaagtct gtaaacggag attagtttgg attatatgac acaggagaca ataaaacatg    840
 ttctcaaaga catgccaata cattttcttg aaacaaaacc tcagcaaatg agaattttca    900
 tactgtgcat gggaataact aaaaccttta ttagatatga ttttccatta acaataatgt    960
 gaaaattaga attatgaatt caaaaagcag tgaagtctga aaatttaaaa agtagactag   1020
 gtattagggg attaaaggta aaggaagacg agaatgtttc tttaatacta ttcattattt   1080
 cccctctgta cacaatgttg catatataca actacttcat ttttattgac tttatataat   1140
 agtgaaatcc ctttaagcaa cctagggtat acagttggtg tccaactttc aggggatttt   1200
 cgggggggag tagaaacact tgattaacag ttttcaccca cacacgttag acaatttttt   1260
 tctttttttg ccaagatttt agtagtaaat tcataaatat aggaaatact ttcactcctt   1320
 cagtgttaaa atagaaaacc aaacagtgcc aacagtagtg gcttaattat tggtatacaa   1380
 gaaaaacaca acaacaatgg gttttcttaa ttacgcattt taaatatcaa tatgtgcatt   1440
 tgtttttaca gttataaatt tttttctcac ctgttttaga caacagcttg taatagtttt   1500
 gaatccatta agatgttgct ttcaatttga aatattttgt gtatacatgt atataaaaaa   1560
 taacccaatg tatgactcat ctgaccgatg tttaagatca ataacggctt atttttcaac   1620
 atgcagttag gaagagaggg aagcaagcca acctctctac agtatctttt tgctggcttg   1680
 tttttgtagt ggtatcaata gtggtttttg gagggaacca tgtgccttca gcctatctag   1740
 tcaagatcag ataccacgat caacaagagc ggtagaagag atggggaaag gggagtgggt   1800
 aagtgttaaa tatcaatttt gtaaagtgtg cattttgtac tccttctagg cacaggatta   1860
 aaaacaggcc aatgaggaaa aatttgttat aattaggaaa aaactgcaat caaatcaaga   1920
 cataatagcc gaattaagtt cttttaatag attgcatata tagatgttta gccatactct   1980
 tagatcaact ctttaagagc agaactttat atccaattta catgctctag ataccacctt   2040
 ttttattttt tacagtaagg tctggtattc aaatacccac ttgtacactg acagctttaa   2100
 gaaaaacagg acacagaggg agttgtcatt tttagcagca atgaaatacc actaacccct   2160
 ttttacatac cgaattcaag tcactatcag aggtgagtgc accacaaagt caccaggtac   2220
 aaaattgcta gttcattttt aaattaataa cttgaaatta cccctgcccc ccaccccatt   2280
 acatcttttt ataaacagca aacattttgc tatttttaat accatagggc taggcaggct   2340
 tgtttcaata tgaaagtgct aattcattta cagattttta taatcagtta tgtagtgcta   2400
 caataaatgt ccaataatct acataggaac aatgatgaaa atgatgaaga ctgaataagg   2460
 ctatcagatg accttatctt atttacatat aaagaataga tacccaatgg tgaggaagag   2520
 acagaaattg gacaaatact cataggtgta aaaattacat ctacctttga gttttatact   2580
 gtaaatgaga cattttaaat agtcctgtag cccatgccta ttttttcctc agaaaaagaa   2640
 aagctgcctt catgacatcc cctcgtttca gatttccaca gtgtcacttt gaagcttcag   2700
 agtcaggatc ttactttctt caaaaaataa agaaaatact cccctcctaa ggtacctccc   2760
 atcccccccc acccccaaaa tcccgctgat ttcttttcca gtgccaggtt gcatgatcag   2820
 gtcccatctc ctggggttgt tgtttctttt gtccatctat tgattattag tttagaatag   2880
 ataacatgaa ccagttctgg aaccactact aggaggaaca caagctcttc actacaagca   2940
 cacagcagga aagaaagaga taactcaatt catccctggt gctgggcctc caaaattgaa   3000
 agaacttggc acaactggga gcactgaatt tgtatcctcc atgcttctca atcattttgg   3060
 attcatgggc tgctcttctt tgatcagcca gagttgctat gtcctgtaac tgttttcttt   3120
 gttcttcatt aagaccgtga gtcagtgcct gataccacac aggattacga ttttgaatag   3180
 tttgaaagat agctttaaat atctgatact catcaacagg gttatcttca tcatcaatga   3240
 ttgtggaata gccttccaga gcagtctctt cagcatcatc ttcttcccaa tcttcatcat   3300
 ctccatcttc accagcctgc ttagccagaa tctccaaata ttcttgccca tcttcatcaa   3360
 tatcatcttc atcactcccc agttcctcgg tttcatcatc atcttcagct tcatcatcat   3420
 catcactgtc attctcatgt tctgcatggc aggcatatgc tcttttcaat ccgttaaata   3480
 aaaggataaa agctggcaaa atctgtccag aaacctgatt taaaccttgg ggtatctgtt   3540
 ccatatcaat aagagcacag agactgagaa cacacatcct tctgtcatga agccccaaga   3600
 aacagtcaac atcattaagc cactaataaa atgatttgta actggttcaa cattattagg   3660
 gaagtgaaga ttttctaagg tatttagtaa taggtatgca ttataatgta aagctgcaat   3720
 tgcaacttgc agacccatag ttcaaagttc acttgtctta acctctcttg tcagtctttc   3780
 taaggctgct tccacgaata agggaatgca ctggtcaatg ccacgccctt tgcactgcag   3840
 aatgatgacc tctaacaatt ttgctgcatg acactctgca tcttctcctg caactcctgt   3900
 aagaaccttt ttgcacatac tgtatatcat ttcaagatac ttggtgtcag acagaagtgt   3960
 gtctgtatca actgttacat aattatgaag gaggggcatc atatctgtaa agtaatcaaa   4020
 gccatcttgc tgaaagactt caaatacaag gggtagtagc tgccacatct gtggagacac   4080
 ttgttgacat gtcaaactgt gcgctaaaga gaagatctcc tcatagaatt ctaagacatg   4140
 ctgttgtaaa acagtaccaa tgacctgtaa gcagattccc tcaagctgtt gggttatctc   4200
 tttatgatct tcaactacac taagaagtgt atcaattgta ttcagaattc ccatagcagt   4260
 aactgctttg tcatcactac cttcttcatc tggccccgtc tggattactt ggttaaatgt   4320
 cattgccaaa tgttgtgtca tttctactgc aataggagta acttcttcac tatattcaca   4380
 gatcattttc tgaattacat tggtaaggtc atcattttct gtttctctta taatgtgaag   4440
 aagagcctgc attacaggtc tgatgaatgg tgtgatatat tctttagctt tttcttgatt   4500
 gctgatcaat acttgaaggg caatggcagc ttccactttc acaggcattt ctctatcatc   4560
 aatcagacat cttcttgtta gctctaaggc tgtttgaagg ttctgatcac ttttgaactt   4620
 cacttcacaa aaatagtgaa gtacccagca agcccttgct ctcatgtagg cctagttcac   4680
 tgctggaaga gaggggaata catggattct ggcaacatgt attccatctg atctttatag   4740
 gatctttttc ttcagaagta tttcagctaa agagccaatc atatgcaggg ctccatcttt   4800
 ttttcgaggg tcagcatttg gttctgtaag aatctggtaa caaaatccca tagtcttttg   4860
 cagtacctct ttcctcttac tacaggctgt aaacaaaagt gtctgggcag cagtggtagg   4920
 agaaatgaaa tcttcaaaca catcaaactt catgcgtata tattcgtaag ggtcttcttg   4980
 ccaaagttcc tcatcagcat ctgtatagca catcaatgga aaaataacat cttggataat   5040
 gccttgtata tggggcttca gattcttcca ggtgagagca tgagaaactc cttgattaat   5100
 ataatttaat gtctgttgta aaactcgagg agccatatat tgcttctcct tgtactgata   5160
 taacaccttc aataaaactt gctggacacc aacagcaaat gccttcagaa atacttcagc   5220
 aaattcatta tactccttgg aaacattgcc agggcttcca tatctttcaa aaagtcttgc   5280
 taaaatatgt aaggcccact tcttgcattt ccaccatggt aactcaggtc gatcatcttc   5340
 ttcaacttga agtgtttcat taggtacatc cctgttcaca acagtcttta aaatttctat   5400
 ccattctgtc aggttctgtt ggtttatcag ttccagtggt agtgtatact gaacaagagc   5460
 atagaagatc ttgaatatct gtttctggat gaggacagac tgatcagact ggtcagaaag   5520
 aagctggata aaacgatcct ttagaactgg cagaaaatgc tgcattgctg ctaccaatgg   5580
 actccgctcc tctggttttt tatactcata atttttcaca agctgataaa ggcaaagaag   5640
 aattcctagc caacaagcac tgttatcgga ctgaagataa aagccaattt tgtccacaat   5700
 ggcagtccag cggcttggat aatcatgttt gatgatgtga tgaatgcatg tagtaagctg   5760
 taccctgatg agctcaggag aatggataat ggcttctaca atattttctc gaatacaatg   5820
 gcgatcttct tctggaatag tataagggga tatatcccct ggtgctgttt ctcgatcagg   5880
 ccaatactgt gttatcatat ttttcagata gataacacct gcctgtctca caggtaaatc   5940
 cagctgttcc gacatagtaa tctggagcag tgttgagaca aaattcagag acttgtgtgc   6000
 ttcattgagc tggcgctccg cggcctcacg cagggctggg tccatggtgc cccgcagggc   6060
 ctcgataatg gtgttggggt ccatcgcagc gcggactcgg tcaaacccgg ggctcgggtg   6120
 ctactgggcc aggaatagcg ccactcactg cgcacatgga cccgccgcgc tccgcagcgg   6180
 caaccggcgc gaaaggaaag agcg                                          6204



      <210> 1664
      <211> 2441
      <212> DNA
      <213> Homo sapiens


      <400> 1664
 tttcgtcgct gagctgaagg ctgtgcggag cggcgcggca cagagcctgt tgttgagctc     60
 agtatgtcgt gggaatccgg ggccgggcca ggtctaggtt cccaggggat ggatctcgtg    120
 tggagtgcgt ggtacggaaa gtgcgttaaa gggaaagggt cgttgccact ctcggcccac    180
 ggcatcgtgg tcgcctggct cagcagggcc gagtgggacc aggtgacggt ttatctgttc    240
 tgtgacgacc ataagttgca gcggtacgcg cttaaccgca tcacggtgtg gaggagcagg    300
 tcaggcaacg aactccctct ggcagtggct tctactgctg acctgatacg ctgtaagctc    360
 ttggatgtaa ctggtggctt gggcactgat gaacttagac tgctctatgg catggcattg    420
 gtcaggtttg tgaatcttat ctcagagagg aagacaaagt ttgccaaggt ccccctcaag    480
 tgtctggctc aagaggtaaa tattccggat tggattgttg accttcgcca tgagttgacc    540
 cacaagaaaa tgccccatat aaatgactgc cgcagaggct gctactttgt cctggattgg    600
 ctccagaaga cctattggtg ccgccaactg gagaacagcc tgagagagac ctgggagttg    660
 gaggagttca gggaagggat agaggaagag gatcaagagg aagataagaa cattgttgtt    720
 gatgacatca cagaacagaa accagagcct caggatgatg ggaaaagtac ggagtcagat    780
 gtaaaggccg atggagacag caaaggcagc gaagaggtgg attctcattg caaaaaggcc    840
 ctgagtcata aagagctata tgaaagagcc cgagaactgc tggtatcata cgaagaggag    900
 cagtttacgg tgctggagaa atttaggtat ttacctaagg ccattaaggc gtggaataac    960
 ccgtccccac gtgtagaatg tgtcctggca gagctcaagg gcgttacatg cgagaacagg   1020
 gaggctgtgc tggatgcttt tctggatgat ggcttccttg tccccacatt tgaacagttg   1080
 gcagctttgc agatagaata tgaagaaaac gtggacttga atgacgtcct ggtgccaaag   1140
 ccgttctctc agttctggca gcccctgctc aggggcctgc actcccagaa cttcacgcag   1200
 gccctattgg agaggatgct ctctgaactg ccagccttgg ggatcagcgg gatccggcct   1260
 acgtacatcc tcagatggac cgttgaactg atcgtggcca acaccaagac tggacggaat   1320
 gctcgccgat tttctgcagg ccagtgggaa gcaagaaggg gctggaggct gttcaactgc   1380
 tccgcctccc ttgactggcc ccggatggtt gagtcctgct tgggctcacc ttgctgggcc   1440
 agcccccaac tccttcggat catctttcaa agccatgggg cagggcttgc aagacgaggg   1500
 agcaggagaa gttgttgcgc atctgttcca tttataccca gagtggagaa aacagcctgg   1560
 tgcaggaggg ctctgaggcc tcccccattg ggaagtctcc atatacacta gacagcctgt   1620
 attggagcgt caagccagcc agctccagct tcgggtctga agcaaaggcc cagcaacagg   1680
 aggagcaggg cagtgttaat gatgtcaagg aagaggagaa ggaggagaaa gaggtcttgc   1740
 cagaccaggt agaggaggag gaagaaaatg atgaccaaga ggaggaagag gaggatgaag   1800
 atgatgaaga tgatgaagag gaagacagaa tggaggtggg gcctttctct acagggcaag   1860
 agtcccccac tgccgagaat gctaggcttc tggcccagaa aagaggagct ttgcagggct   1920
 ctgcatggca ggttagctca gaagacgtgc gatgggacac atttccccct aggccgaatg   1980
 cccaggtcaa gaccgaggac cccagcagag ctcatgctgg agaattatga cacccatgta   2040
 atcttttgga ccaagcctgt gcttagagca gcggctggaa ccctcaacat gcaaagactg   2100
 acaccttggg cctgaagctg tggtgtcggc agttggcaac tgcagcaaca gcagcagcag   2160
 caactttcga ggggcctttc tcttggaagc caggggaagc ttgcattggg ctccaaaact   2220
 ggcctgcagc tcttctgatt ggccatccct ggtgcaagtg ttcatccagc cgtgccaggg   2280
 catctattta tcccctagta caactgatgc tccctgagac aacctgggag acagcctgga   2340
 tcagccacat caactcagtt gtccaccaca ggggaatttt gaatgtcttt tgtttttgtt   2400
 ttgttttgaa aaataataaa caggcaactg taaaaaaaaa a                       2441



      <210> 1665
      <211> 528
      <212> DNA
      <213> Homo sapiens


      <400> 1665
 ctgggaaaca cagttctaca ctactgtagt atgtacagta aacctgagtg tttgaagctt     60
 ttgctcagga gcaagcccac tgtggatata gttaaccagg ctggagaaac tgccctagac    120
 atagcaaaga gactaaaagc tacccagtgt gaagatctgc tttcccaggc taaatctgga    180
 aagttcaatc cacacgtcca cgtagaatat gagtggaatc ttcgacagga ggagatagat    240
 gagagcgatg atgatctgga tgacaaacca agccctgtca agaaagagcg ctcacccaga    300
 cctcagagct tctgccactc ctccagcatc tccccccagg acaagctggc actgccagga    360
 ttcagcactc caagggacaa acagcggctc tcctatggag ccttcaccaa ccagatcttc    420
 gtttccacaa gcacagactc gcccacatca ccaaccacgg aggctccccc tctgcctcct    480
 aggaacgccg ggaaaggtcc aactggccca cctatcactc cccataga                 528



      <210> 1666
      <211> 421
      <212> DNA
      <213> Homo sapiens


      <400> 1666
 ggcacagagc ccccggaact ggcatctgca gggcgtgagc ttttgccgcc gcgatgccgc     60
 acttcctgga ctgggtcgtg ccggtctact tggtcatctc ggtcctcatt ctggggggct    120
 tcggcgcctg catctactac ttcgagccgg gcctgcagga ggcgcacaag tggcgcatgc    180
 agcgccccct ggtggaccgc gacctccgca agacgctaat ggtgcgcgac aacctggcct    240
 tcggcggccc ggaggtctga gccgacttgc aaaggggata ggcgggcggc accgggcgcc    300
 cttccccagc ccgccccgcc cgcccagccc ggagaccccc aaggcagagg gaggccggcc    360
 tgttggccct ccacgctatc cctctgcagc ctgggccctc ccgacagagg ccccaggggc    420
 g                                                                    421



      <210> 1667
      <211> 2843
      <212> DNA
      <213> Homo sapiens


      <400> 1667
 gtaagtgcgg tggaattcgt gctccatggg aaagatttcc aagtagattg caaagcttcc     60
 ggctccccag tgccttagat atcttggagt ttgcttgatg gaaccatgat caacaatgca    120
 atgcaagccg atgacagtgg ccacaggact aggagatata cccttttcaa caatggaact    180
 ttatacttca acaaagttgg ggtagcggag gaaggagatt atacttgcta tgcccagaac    240
 accctaggga aagatgaaat gaaggtccac ttaacagtta taacagctgc tccccggata    300
 aggcagagta acaaaaccaa caagagaatc aaagctggag acacagctgt ccttgactgt    360
 gaggtcactg gggatcccaa accaaaaata ttttggttgc tgccttccaa tgacatgatt    420
 tccttctcca ttgataggta cacatttcat gccaatgggt ctttgaccat caacaaagtg    480
 aaactgctcg attctggaga gtacgtatgt gtagcccgaa atcccagtgg ggatgacacc    540
 aaaatgtaca aactggatgt ggtctctaaa cctccattaa tcaatggtct gtatacaaat    600
 agaactgtta ttaaagccac agctgtgaga cattccaaaa aacactttga ctgcagagct    660
 gaagggacac catctcctga agtcatgtgg atcatgccag acaatatttt cctcacagcc    720
 ccatactatg gaagcagaat cacagtccat aaaaatggaa ccttggaaat taggaatgtg    780
 aggctttcag attcagccga ctttatctgt gtggcccgaa atgaaggtgg agagagcgtg    840
 ttggtagtac agttagaagt actggaaatg ctgagaagac cgacatttag aaatccattt    900
 aatgaaaaaa tagttgccca gctgggaaag tccacagcat tgaattgctc tgttgatggt    960
 aacccaccac ctgaaataat ctggatttta ccaaatggca cacgattttc caatggacca   1020
 caaagttatc agtatctgat agcaagcaat ggttctttta tcatttctaa aacaactcgg   1080
 gaggatgcag gaaaatatcg ctgtgcagct aggaataaag ttggctatat tgagaaatta   1140
 gtcatattag aaattggcca gaagccagtt attcttacct atgcaccagg gacagtaaaa   1200
 ggcatcagtg gagaatctct atcactgcat tgtgtgtctg atggaatccc taagccaaat   1260
 atcaaatgga ctatgccaag tggttatgta gtagacaggc ctcaaattaa tgggaaatac   1320
 atattgcatg acaatggcac cttagtcatt aaagaagcaa cagcttatga cagaggaaac   1380
 tatatctgta aggctcaaaa tagtgttggt catacactga ttactgttcc agtaatgatt   1440
 gtagcctacc ctccccgaat tacaaatcgt ccacccagga gtattgtcac caggacaggg   1500
 gcagcctttc agctccactg tgtggccttg ggagttccca agccagaaat cacgtgggag   1560
 atgcctgacc actcccttct ctcaacggca agtaaagaga ggacacatgg aagtgagcag   1620
 cttcacttac aaggtaccct agtcattcag aatccccaaa cctccgattc tgggatatac   1680
 aaatgcacag caaagaaccc acttggtagt gattatgcag caacgtatat tcaagtaatc   1740
 tgacatgaaa taataaagtc aacaacatct gggcagaatt tattttttgg aagaagttta   1800
 atcaaaggca gccataggca tgtaaatgaa tttgaataca tttacagtat taaatttaca   1860
 atgaacatgc aaaataaaag gacttgtaaa taaatgcatt atgaactgat gatactgatt   1920
 tatttaatgg atctcaaaac aaacttttaa cttaaggcac ttttattttg ccaacaaata   1980
 acaataaaca aacattgaaa cggttcacta taaaataaca aatggctaat gtacctgaat   2040
 ttttcagtaa aaaaatgaac ttctaatacc agttgcccta gtgtccacct cctatccaat   2100
 gttaccaagc atggcactcc agaaccagag accaatggaa aatattaaat ctggcaatct   2160
 ttatgatgta aatttaccat cctgatgtat aaatattttg tggtttataa atttttttgc   2220
 taaaacctac agaaaataag cactgaactg tcttatgatt caccatttgt tcacactgaa   2280
 aattttcatt gatggggaat acaaaaatgt tttaataact gcatttaaaa ataaatgcag   2340
 gctcactttt ccacatgtaa aaagcaatgt aatacctgca catcataaaa tgtgaaaagg   2400
 gggttatttt tgtccaaata cacccattaa aaaggtttta aaaatacaat gaaacttctt   2460
 tataacttta aaatctagct caggcacccc tggtttggag ctgtttataa ggaaattttt   2520
 ctgagcagga atcgttgctc tataagcatt tcatttcatt aattctttat gggatgggaa   2580
 aatgcttggg agggtctagg tctattatat ataatgaagt ttcactgtat ttaaaatctg   2640
 atcaatccta cacaaaatgt gtttttgtaa ttcactgaat ttatattaca tgcttaattc   2700
 aacctgaatt aatttgggga atattaaatg attgatctta tctaaatcta ggggtggggt   2760
 tttccagtgt aatttctcca gcatctattc aaacattcac ctagtactta cttacttaag   2820
 aattatagga gctttataaa tgg                                           2843



      <210> 1668
      <211> 2457
      <212> DNA
      <213> Homo sapiens


      <400> 1668
 ttttttcacg gacagacagg gtcgtttgtc acagcagaga agcacctcac ggctcctacc     60
 cgcactcatc gcggacagtg cctgcagcgg gagcggcgcg agcaccctcc ccagatgaaa    120
 acaccagcac caggaggtgg gccgtagccc aggctgaggg aggaggctgg gggctggggc    180
 tcagggcccc cccccggcca cagcgccacc ctgagtggcc ctgaaaatag tgcacagtgc    240
 tgggtactgc cccggccgga ggcacctagt tgttgagcat tccggccaca ggccacccgc    300
 tggcccttcc ttggtgtggc acgagaccac gggcacttgc aggagctccc tgcatgctgt    360
 tttgtgcttt ggtctcaggg agcaccctcc tacctcgggg tcccagagtg ggcagccggg    420
 caggtgtgaa cagtgtgaca agggtaccgt ggggcacctg gtagtgccac ccagaggggc    480
 agccggtgct cctggtggtg tggcagcaac agttacaaac tcaccccaag tccaaacccc    540
 agaaatcctg tttctctggc cctccgggtc cagaatgccc tgcactgcct cctggcctca    600
 ggggctgctg cggtggtggg aaggctgccc agcagtgagg aaggcgagtg caggggctgc    660
 ggccgcggtc agagaaggag agacaccagc agaggacgcg aagctgcgac cggccaggtt    720
 cagagcccgc ctcggttgct cccaatcaga atctgctttg tgctccacgg cctccaagca    780
 ctttcatgag cgttctgctc ctacgtggcc aggtcctacc ttccctgacg gctctggcca    840
 ggccagctcg gtttccctct aacccatgag gcctgggggg gctgtgacag aggctggaag    900
 cgtggccaga gcccaggggc aggcccgcct ggtcacagca ggatgaggct ggggtggcgc    960
 agctgccggt acacctgtag cagcctctgg gcggtggcac aggagctggc ctcatcctcc   1020
 gtgcagagcc ggtcgcgcag ggtctgcacc tcccgcagca gtgtctcgtg gttggcgtgg   1080
 atctggcgga ggtactgcac acggagatca ggagcgctgg agccctgggc ggcctgctct   1140
 gtcaccatcg tctgcatgcg cccgacaacg gcatggtgcg ccctgcaaat gtcggccaga   1200
 gaggagcttt ccacttgaat ctccacggcc tggatgggcc ctgctgggca caggtcggtc   1260
 atggccacct ctcggacgat gaggtgaacg ttggcgccat caggggccac tccctggatg   1320
 gaagatagtg ctcgggccct cacgacgtcc acagcagcat tctcagcaag gagccactgc   1380
 agggtggcac agcacagggg cacgcctgag tggccgtcct tcaaggcagc tctgagcagc   1440
 tccgccgaca ccttgatgga agccacagat gggggcaggt actcggcccg cagggaggcg   1500
 ggtcctgctg gctggctgcc aggctcccga caagtttcca gaaaagtggc cacagggtct   1560
 cgggtggggc cgagtgggga gggggcccgt gtgtgtggca gggccaggcc agggaagcgc   1620
 agacactgca gcatgtccac tgtgtgcctg ctcaggggca ggcaaacacc ctcttgctcg   1680
 ggcaggacgt cggaggggca ctcatccaga aaggggtcct cagagtctga gggggcaagg   1740
 gccccgccca ccacctccct gagactgtag aacagcgtgc aggacacggt cacgggcagg   1800
 tcgagcccgc cgttctcacc agggcccagg ggtagcgtca cctcccgccg agcaccgggg   1860
 ccgagctggt ccacggggat ggtgtaggtg atggcggagc aggccgagtc caggtcgaga   1920
 gcacaggagc tggtgagcac ctggatgcac agggtccacc cctggtccag gctgaagctg   1980
 ctgctgttct ctagcacgca ggtggccatg agcacatcct gtgtctgcag gcggctccag   2040
 gtggtgctgg tggtgcagga gatgggtctg gggcccgtgc cgcttgacag cagtgcacag   2100
 ctcacgttca tggcctcgtt gaggcttgtc agtgccttgt tccgctggtc aaccgccttc   2160
 tttagaaaag acactctctc agagatgttg ccaattccag acagcagctc ctttattttc   2220
 tgacctgcac tctctgtggt catcctggct gggccaggca tctcagagtc caggtccagg   2280
 ctgcaggtca tcaggcggcc tttggcggac agggccagga gcttggtgcc accttcatgc   2340
 gtcctgggag acgcggacag cgagacgaca ctgcagatgt tcaggctggc tgggcacagc   2400
 atggggggca ggcctcccgg gccttcttcg ggctgctcag ggcccagcgg ggtgttt      2457



      <210> 1669
      <211> 590
      <212> DNA
      <213> Homo sapiens


      <400> 1669
 tactccagat catctgacta actcttaaaa atcacggcca ggcacagtgg ctcatgcctg     60
 taatcccagc actttgggaa gcagaggtgg caggatcatt ccagcccagg agttcaagac    120
 cagcctgggc aacacagtga gtgagaccct gtctctattt aagaaaaaat aattaagaaa    180
 ttttattaaa aaagaagaat caggaaacca agtccaaccc aactaaacct caaatgaacc    240
 agcccctaac acagatgagg ggatttggga ctgataagct ctgtgctgtg tccatggccc    300
 gtcatttatc aaggctgcag ctttgtaaat gtggctattt ttatgttgtg tatagtttct    360
 atcatttatt tttccactgg atttgagtaa agtttttttt cttttttttg ggaaagaccc    420
 ttctgtctca gttttgctat gagaaaaggg atttttgggc cctgaacgcg ggcatgctgg    480
 tggcctcagg aatacgagga aaagagctgg agctccctct atcttctctg ctgtcacact    540
 ggaaggcagc ctacattttg tcctaataag gacagctctt caagaaggcc               590



      <210> 1670
      <211> 590
      <212> DNA
      <213> Homo sapiens


      <400> 1670
 tactccagat catctgacta actcttaaaa atcacggcca ggcacagtgg ctcatgcctg     60
 taatcccagc actttgggaa gcagaggtgg caggatcatt ccagcccagg agttcaagac    120
 cagcctgggc aacacagtga gtgagaccct gtctctattt aagaaaaaat aattaagaaa    180
 ttttattaaa aaagaagaat caggaaacca agtccaaccc aactaaacct caaatgaacc    240
 agcccctaac acagatgagg ggatttggga ctgataagct ctgtgctgtg tccatggccc    300
 gtcatttatc aaggctgcag ctttgtaaat gtggctattt ttatgttgtg tatagtttct    360
 atcatttatt tttccactgg atttgagtaa agtttttttt cttttttttg ggaaagaccc    420
 ttctgtctca gttttgctat gagaaaaggg atttttgggc cctgaacgcg ggcatgctgg    480
 tggcctcagg aatacgagga aaagagctgg agctccctct atcttctctg ctgtcacact    540
 ggaaggcagc ctacattttg tcctaataag gacagctctt caagaaggcc               590



      <210> 1671
      <211> 960
      <212> DNA
      <213> Homo sapiens


      <400> 1671
 tttttttttt ttaaaattct aataaaataa atattttatt aacgaaagtc tggaaaatgt     60
 gtgcactaaa aagtgactat aaatgttaaa ttaaaaaacc ttcaaagaac acatatcaca    120
 cattcaattt ttaaaacttt atataaaagc tctattataa atacaaagct aaactatctg    180
 agtactaaca acacagttca tacaaagaaa cttaacagta gtaaaataca gatatataag    240
 atgcttattt ttggtccttt aggataaaag aactaagttg gtttttttca catggctcca    300
 ggcacaaaaa tagaatataa gatggtaact gcaacattct tagtgtttat ccttgtaatt    360
 ctttaaatgt caccagtcat aatagcaatg aactcctctt ggtttatttc tccatcacca    420
 tctttgtcaa attcttctat catagctcga agttcttcat cactcatgtt ttcacccaat    480
 tctctagcaa cacgtcgcaa attcctcaag cttattttac ctgaatcatc atcatcaaat    540
 agtttaaatg ccttgagtat ttcttcatgg ggatctcttt ccaatatcca gtctgtcaca    600
 acttcattaa aatcttcaaa ggtgattttc cctgtggctt ctctgtcata atctttaaga    660
 atcttcagta catcagcttt ttttacatca aaccccaagg ctctcattgc cacctttaat    720
 tcatgataat ctattgcttc atctttgtct gtatcaaata gttcaaaagc atctttaatt    780
 tcttgtttct gttcctcaga cagttctctt ctttttttcc tctttgtttt gtccactaca    840
 agctcacttc tcagagctaa actcattatc tcttcgcaca gagacgttcc tctcaagaac    900
 gattttaacc ccctacccaa ggcagcaaga cgcccacagc cgttcaaccg gacgcgtggg    960



      <210> 1672
      <211> 1834
      <212> DNA
      <213> Homo sapiens


      <400> 1672
 ttgcagtgag ccaagatcac accactgcac ttcagcctgg gcgacagggc aagactgtct     60
 cggaaaaata aaagaaagaa gatgctgata tgctacaaca cggatgaacc tggaggacgt    120
 ggtgcagtga aataagctgg tcacagagag acaaatcctg ggtgatccca cttacatgag    180
 acaggccgac ggtcgcaagg tcctacggtc aagcatccgg gagtttctat gcagcgaagc    240
 catgttccac ctgggagtcc ccaccacacg ggccggcgcc tgcgtcacgt ccgagtccac    300
 ggtggtgcgc gacgtgttct atgatggttt ggatcctttg agatttttaa gtctgcagat    360
 gagcacacag ggcgtgcagg ccccagcgtg gggaggaacg acattcgagt gcagctgctc    420
 gactatgtca tcagctcctt ttaccccgag atccaggctg ctcatgccag cgacagcgtg    480
 cagagaaatg ctgccttctt ccgggaggtg acgcggcgca cggcgcggat ggtggccgag    540
 tggcagtgtg tgggcttctg ccacggcgtg ctcaacaccg acaacatgag catcctgggg    600
 ctcaccatcg actacgggcc ctttggcttc ctggacaggt acgaccccga ccacgtgtgc    660
 aatgcctccg acaacaccgg ccgctacgcg tacagcaagc agcccgaggt gtgcaggtgg    720
 aacctgcgga agctggccga ggccctgcag ccggaactgc ccctggagct gggggaggcc    780
 atcctggccg aggagtttga cgccgagttc caaaggcact acctgcagaa gatgcgcagg    840
 aagctgggcc tcgtgcaggt ggagctggag gaagacgggg cgctggtgtc caagctcctg    900
 gagaccatgc atctgaccgg tgccgacttc acaaacacct tctacttgct gagctccttc    960
 ccagtggagc tagagtcgcc aggcctggcg gaattcctgg ccaggctgat ggagcagtgt   1020
 gcctccctgg aggagctgag gctggccttc cggccccaga tggatccccg gcagctatcc   1080
 atgatgctga tgctggcgca gtcaaacccg cagctgttcg cgcttatggg cacccgggca   1140
 ggcatcgcca gggagctgga gcgtgtggag cagcagtctc ggctggagca gctgagtgcg   1200
 gcagagctgc agagcaggaa ccagggccac tgggctgact ggctacaggc gtacagagcc   1260
 cggctggaca aggacctgga aggcgctggg gacgctgccg cctggcaggc tgagcacgtg   1320
 cgcgtgatgc acgccaacaa cccgaagtac gtgctgagga actacatcgc gcagaatgcc   1380
 atcgaggctg ccgagcgcgg ggacttctca gaggtgcggc gggtgctgaa actactggag   1440
 accccttacc actgcgaggc gggggccgcc acagacgccg aggccacgga agccgacggg   1500
 gcggacggca ggcagcgctc ctacagcagt aagcccccgc tctgggcagc agaactgtgc   1560
 gtgacatgat cttcgtaacg acctcggcac gatccacacc cctggagtct cccgaggccc   1620
 ccatgtgctg ctgagtggcc aagatgatgc caggctgccc tatacactgg gggattctgc   1680
 cctggcccat gcacacccgt ctttccatga tggcagagac atccagtcag gacctgaccc   1740
 gtctctgtct gaggccggct cagcagtgca gcctggtccc tgggggctgg acccaggctc   1800
 ctaaataaac cagcaactcc ctcgaaaaaa aaaa                               1834



      <210> 1673
      <211> 1834
      <212> DNA
      <213> Homo sapiens


      <400> 1673
 ttgcagtgag ccaagatcac accactgcac ttcagcctgg gcgacagggc aagactgtct     60
 cggaaaaata aaagaaagaa gatgctgata tgctacaaca cggatgaacc tggaggacgt    120
 ggtgcagtga aataagctgg tcacagagag acaaatcctg ggtgatccca cttacatgag    180
 acaggccgac ggtcgcaagg tcctacggtc aagcatccgg gagtttctat gcagcgaagc    240
 catgttccac ctgggagtcc ccaccacacg ggccggcgcc tgcgtcacgt ccgagtccac    300
 ggtggtgcgc gacgtgttct atgatggttt ggatcctttg agatttttaa gtctgcagat    360
 gagcacacag ggcgtgcagg ccccagcgtg gggaggaacg acattcgagt gcagctgctc    420
 gactatgtca tcagctcctt ttaccccgag atccaggctg ctcatgccag cgacagcgtg    480
 cagagaaatg ctgccttctt ccgggaggtg acgcggcgca cggcgcggat ggtggccgag    540
 tggcagtgtg tgggcttctg ccacggcgtg ctcaacaccg acaacatgag catcctgggg    600
 ctcaccatcg actacgggcc ctttggcttc ctggacaggt acgaccccga ccacgtgtgc    660
 aatgcctccg acaacaccgg ccgctacgcg tacagcaagc agcccgaggt gtgcaggtgg    720
 aacctgcgga agctggccga ggccctgcag ccggaactgc ccctggagct gggggaggcc    780
 atcctggccg aggagtttga cgccgagttc caaaggcact acctgcagaa gatgcgcagg    840
 aagctgggcc tcgtgcaggt ggagctggag gaagacgggg cgctggtgtc caagctcctg    900
 gagaccatgc atctgaccgg tgccgacttc acaaacacct tctacttgct gagctccttc    960
 ccagtggagc tagagtcgcc aggcctggcg gaattcctgg ccaggctgat ggagcagtgt   1020
 gcctccctgg aggagctgag gctggccttc cggccccaga tggatccccg gcagctatcc   1080
 atgatgctga tgctggcgca gtcaaacccg cagctgttcg cgcttatggg cacccgggca   1140
 ggcatcgcca gggagctgga gcgtgtggag cagcagtctc ggctggagca gctgagtgcg   1200
 gcagagctgc agagcaggaa ccagggccac tgggctgact ggctacaggc gtacagagcc   1260
 cggctggaca aggacctgga aggcgctggg gacgctgccg cctggcaggc tgagcacgtg   1320
 cgcgtgatgc acgccaacaa cccgaagtac gtgctgagga actacatcgc gcagaatgcc   1380
 atcgaggctg ccgagcgcgg ggacttctca gaggtgcggc gggtgctgaa actactggag   1440
 accccttacc actgcgaggc gggggccgcc acagacgccg aggccacgga agccgacggg   1500
 gcggacggca ggcagcgctc ctacagcagt aagcccccgc tctgggcagc agaactgtgc   1560
 gtgacatgat cttcgtaacg acctcggcac gatccacacc cctggagtct cccgaggccc   1620
 ccatgtgctg ctgagtggcc aagatgatgc caggctgccc tatacactgg gggattctgc   1680
 cctggcccat gcacacccgt ctttccatga tggcagagac atccagtcag gacctgaccc   1740
 gtctctgtct gaggccggct cagcagtgca gcctggtccc tgggggctgg acccaggctc   1800
 ctaaataaac cagcaactcc ctcgaaaaaa aaaa                               1834



      <210> 1674
      <211> 455
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(455)
      <223> n = a,t,c or g


      <400> 1674
 nagagggtca gntacctaga nnntctgcnn ntgccggacg agcctgcttc ggttcttcct     60
 ccctctgctt atcatcatct actgctacat cttcatcttc agggccatgc gggagacagg    120
 acgggctctt cagaccttcg gggcctgcaa gggcaatggc gagtccctgt ggcagcggca    180
 gcggctgcag agcgagtgca agatggccaa gatcatgctg ctggtcatcc tcctcttcgt    240
 gctctcctgg gctccctatt ccgctgtggc cctggtggcc tttgctgggt acgcacacgt    300
 cctgacaccc tacatgagct cggtgccagc cgtcatcgcc aaggcctctg caatccacaa    360
 ccccatcatt tacgccatca cccaccccaa gtacagggtg gccattgccc agcacctgcc    420
 ctgcctgggg gtgctgctga gtgtatcacg ccggc                               455



      <210> 1675
      <211> 411
      <212> DNA
      <213> Homo sapiens


      <400> 1675
 ccgggaacat gactaccact tttcccccaa ggaaaatggt ggcccagttc ctcctcgtgg     60
 cgggcaacgt ggccaacatc accaccgtca gcctctggga agaattctcc tccagcgacc    120
 tcgcagatct ccgcttcctg gacatgagcc agaaccagtt ccagtacctg ccagacggct    180
 tcctgaggaa aatgccttcc ctctcccacc tgaacctcca ccagaattgc ctgatgacgc    240
 ttcacattcg ggagcacgag ccccccggag cgctcaccga gctggacctg agccacaacc    300
 agctgtcgga gctgcacctg gctccggggc tggccagctg cctgggcagc ctgcgcttgt    360
 tcaacctgag ctccaaccag ctcctgggcg tcccccctgg ccctctgtat t             411



      <210> 1676
      <211> 489
      <212> DNA
      <213> Homo sapiens


      <400> 1676
 cccacgcgtc cgcccacgcg tccgccctcc ctgacttttc cagcctttca ctttaacttc     60
 ctggagctct aatttctcct tctcagatca gcatccccag aacacacctg tgttaagtca    120
 aagaccttgg acccaatggt catcttcttc accagtggga ccacaggctt ccccaagatg    180
 gcaaaacact cccatgggtt ggccttacaa ccctccttcc caggaagtag gaaattacgg    240
 agcctgaaga catctgatgt ctcctggtgc ctgtcggact caggatggat tgtggctacc    300
 atttggaccc tggtagaacc atggacagcg ggttgtacag tctttatcca ccatctgcca    360
 cagtttgaca ccaaggtcat catacagaca ttggtgaaat accccattaa ccacttttgg    420
 ggggtatcat ctatatatcg aatgattctg cagcaggatt tcaccagcat caggttccct    480
 gccctggag                                                            489



      <210> 1677
      <211> 1238
      <212> DNA
      <213> Homo sapiens


      <400> 1677
 atcttaccaa gatgcatctc acagaaaacc ctcatccaca ggtgactcat gtgtcttcta     60
 gtcagtctgg ttgtagcatt gccagtgact ctggaagcag cagtttatct gatatctatc    120
 aggctacgga gagtgaggta ggagatgtag atttgacacg tcttccagaa ggacctgttg    180
 attctgagga tgacgaagag gaagatgaag agattgatcg aacagatcca ttgcaggggc    240
 gagatcttgt tcgagaatgt cttgaaaaag aacctgcaga caaaactgat gatgacattg    300
 aacaattgct ggagtttatg caccagctcc ctgcatttgc aaacatgacc atgtctgtaa    360
 ggagagaact ctgctcagtg atgatttttg aagtggtaga gcaggctgga gctattattc    420
 ttgaagatgg gcaagagctt gactcatggt atgttatttt aaacggcact gtggaaatca    480
 gtcatccaga tggaaaagtt gaaaatttgt ttatgggaaa tagttttgga attactccca    540
 ctctggataa gcagtacatg catggaattg tcaggactaa agtagatgat tgtcagtttg    600
 tctgcatagc ccagcaagat tattggagaa ttttaaacca tgtggaaaaa aatacccata    660
 aagttgagga agagggagaa attgttatgg tacatgagca tcgggaacta gaccggagtg    720
 gaaccaggaa aggacacatt gtgatcaagg caacacctga gcgtctcata atgcatttaa    780
 tagaagaaca ttccatcgtg gatccaactt atatagaaga ttttctatta acttacagga    840
 catttcttga aagtcctttg gatgttggga tcaaactatt ggaatggttt aagatcgaca    900
 gcttaagaga taaggtgaca cggattgtat tattatgggt aaataatcat tttaatgatt    960
 ttgaaggtga ccctgctatg actcgatttc tagaggaatt tgaaaaaaat ctggaagata   1020
 caaagatgaa tggtcatctc cggttattga atattgcctg tgctgcaaag gctaagtgga   1080
 gacaggttgt gctgcaaaag gcttcccgcg agtcccctct acaattcagc cttaatggag   1140
 ggagtgagaa gggatttggt atttttgttg aaggagtaga acctggtagc aaagctgctg   1200
 attcaggact gaaacgtggt gatcagatta tggaagta                           1238



      <210> 1678
      <211> 1238
      <212> DNA
      <213> Homo sapiens


      <400> 1678
 atcttaccaa gatgcatctc acagaaaacc ctcatccaca ggtgactcat gtgtcttcta     60
 gtcagtctgg ttgtagcatt gccagtgact ctggaagcag cagtttatct gatatctatc    120
 aggctacgga gagtgaggta ggagatgtag atttgacacg tcttccagaa ggacctgttg    180
 attctgagga tgacgaagag gaagatgaag agattgatcg aacagatcca ttgcaggggc    240
 gagatcttgt tcgagaatgt cttgaaaaag aacctgcaga caaaactgat gatgacattg    300
 aacaattgct ggagtttatg caccagctcc ctgcatttgc aaacatgacc atgtctgtaa    360
 ggagagaact ctgctcagtg atgatttttg aagtggtaga gcaggctgga gctattattc    420
 ttgaagatgg gcaagagctt gactcatggt atgttatttt aaacggcact gtggaaatca    480
 gtcatccaga tggaaaagtt gaaaatttgt ttatgggaaa tagttttgga attactccca    540
 ctctggataa gcagtacatg catggaattg tcaggactaa agtagatgat tgtcagtttg    600
 tctgcatagc ccagcaagat tattggagaa ttttaaacca tgtggaaaaa aatacccata    660
 aagttgagga agagggagaa attgttatgg tacatgagca tcgggaacta gaccggagtg    720
 gaaccaggaa aggacacatt gtgatcaagg caacacctga gcgtctcata atgcatttaa    780
 tagaagaaca ttccatcgtg gatccaactt atatagaaga ttttctatta acttacagga    840
 catttcttga aagtcctttg gatgttggga tcaaactatt ggaatggttt aagatcgaca    900
 gcttaagaga taaggtgaca cggattgtat tattatgggt aaataatcat tttaatgatt    960
 ttgaaggtga ccctgctatg actcgatttc tagaggaatt tgaaaaaaat ctggaagata   1020
 caaagatgaa tggtcatctc cggttattga atattgcctg tgctgcaaag gctaagtgga   1080
 gacaggttgt gctgcaaaag gcttcccgcg agtcccctct acaattcagc cttaatggag   1140
 ggagtgagaa gggatttggt atttttgttg aaggagtaga acctggtagc aaagctgctg   1200
 attcaggact gaaacgtggt gatcagatta tggaagta                           1238



      <210> 1679
      <211> 794
      <212> DNA
      <213> Homo sapiens


      <400> 1679
 tttcgtggat ttttagaccg tggagactgc gctgccctgc cctgcaccta ccctcactct     60
 ccgtgttctc actaaggtgg aaattgcctt ccctcactac tgacgagacc atgtgtaaaa    120
 gcgtgaccac agatgagtgg aagaaagtct tctatgagaa gatggaggag gcaaagccgg    180
 ctgacagctg ggacctcatc atagacccca acctcaagca caatgtgctg agccctggtt    240
 ggaagcagta cctggaattg catgcttcag gcaggttcca ctgctcctgg tgctggcaca    300
 cctggcagtc gccctacgtg gtcatcctct tccacatgtt cctggaccgc gcccagcggg    360
 cgggctcggt gcgcatgcgc gtcttcaagc agctgtgcta tgagtgcggc acggcgcggc    420
 tggacgagtc cagcatgctg gaggagaaca tcgagggcct ggtggacaac ctcatcacca    480
 gcctgcgcga gcagtgctac ggcgagcgtg gcggccagta ccgcatccac gtggccagcc    540
 gccaggacaa ccggcggcac cgcggagagt tctgcgaggc ctgccaggag ggcatcgtgc    600
 actggaagcc cagcgagaag ctgctggagg aggaggcgac cacctacacc ttctcccggg    660
 cgcccagccc caccaagtcg caggaccaga cgggctcagg ctggaacttc tgctctatcc    720
 cctggtgctt gttttgggcc acggtcctgc tgctgatcat ctacctgcag ttctctttcc    780
 gtagctccgt ataa                                                      794



      <210> 1680
      <211> 904
      <212> DNA
      <213> Homo sapiens


      <400> 1680
 tttcgtgcag gagccccttg tctttcaggt ggggggcagt atggtttttg ggggcacaag     60
 ctttcctcag tccctccact tggaggggaa ggaatgtggc ctggctggct ggttgggatc    120
 aaggaggagc tttcgggcag gacggggcca gggcaggctg gggcgagggc tcctgctggt    180
 actgtgttcg ctgctgcaca gcaaggccct gccacccaca ttcaggccat gcagccatgt    240
 tccgggagcc ctaattgcac agaagcccat ggggagctcc agactggcag ccctgctcct    300
 gcctctcctc ctcatagtca tcgacctctc tgactctgct gggattggct ttcgccacct    360
 gccccactgg aacacccgct gtcctctggc ctcccacacg gatgacagtt tcactggaag    420
 ttctgcctat atcccttgcc gcacctggtg ggccctcttc tccacaaagc cttggtgtgt    480
 gcgagtctgg cactgttccc gctgtttgtg ccagcatctg ctgtcaggtg gctcaggtct    540
 tcaacggggc ctcttccacc tcctggtgca gaaatccaaa aagtcttcca cattcaagtt    600
 ctataggaga cacaagatgc cagcacctgc tcagaggaag ctgctgcctc gtcgtcacct    660
 gtctgagaag agccatcaca tttccatccc ctccccagac atctcccaca agggacttcg    720
 ctctaaaagg accccaccct tcggttcccg agacatggga aaggcttttc ccaaatggga    780
 ctctccaacg ccaggggggg accggccgtc ctcttttgaa ttgctgccct gaagccccgc    840
 gcttatttcg gggcacgaat atttttccgg acccttgatg gctctccgat cggtctcttt    900
 ctcc                                                                 904



      <210> 1681
      <211> 904
      <212> DNA
      <213> Homo sapiens


      <400> 1681
 tttcgtgcag gagccccttg tctttcaggt ggggggcagt atggtttttg ggggcacaag     60
 ctttcctcag tccctccact tggaggggaa ggaatgtggc ctggctggct ggttgggatc    120
 aaggaggagc tttcgggcag gacggggcca gggcaggctg gggcgagggc tcctgctggt    180
 actgtgttcg ctgctgcaca gcaaggccct gccacccaca ttcaggccat gcagccatgt    240
 tccgggagcc ctaattgcac agaagcccat ggggagctcc agactggcag ccctgctcct    300
 gcctctcctc ctcatagtca tcgacctctc tgactctgct gggattggct ttcgccacct    360
 gccccactgg aacacccgct gtcctctggc ctcccacacg gatgacagtt tcactggaag    420
 ttctgcctat atcccttgcc gcacctggtg ggccctcttc tccacaaagc cttggtgtgt    480
 gcgagtctgg cactgttccc gctgtttgtg ccagcatctg ctgtcaggtg gctcaggtct    540
 tcaacggggc ctcttccacc tcctggtgca gaaatccaaa aagtcttcca cattcaagtt    600
 ctataggaga cacaagatgc cagcacctgc tcagaggaag ctgctgcctc gtcgtcacct    660
 gtctgagaag agccatcaca tttccatccc ctccccagac atctcccaca agggacttcg    720
 ctctaaaagg accccaccct tcggttcccg agacatggga aaggcttttc ccaaatggga    780
 ctctccaacg ccaggggggg accggccgtc ctcttttgaa ttgctgccct gaagccccgc    840
 gcttatttcg gggcacgaat atttttccgg acccttgatg gctctccgat cggtctcttt    900
 ctcc                                                                 904



      <210> 1682
      <211> 400
      <212> DNA
      <213> Homo sapiens


      <400> 1682
 ggtacttcca acagcccagg gcaagcttta tcaagacgat ttgaaggtta atccagctaa     60
 tgtctcccac ttggtttccc ctttcacctg gcagggaccc ggtgggcacc ttaaggcacc    120
 tcagtggacc acttcttccc tctttccctt tcagatccga aatgtgggca cagggctgtg    180
 tgcagacaca aagcacgggg ccttgggctc cccactaagg ctagagggct gcgtccgagg    240
 gccgtgggga ggctgcctgg aacaacatgc aggtaagggc cgcccctcag ggactggcag    300
 ccaggttctc tgaaacatct gcagcctggg gtgctgacac ggccagctgg gagggagagg    360
 catgggtcag tgataaatga caagagtcag ccccggggat                          400



      <210> 1683
      <211> 996
      <212> DNA
      <213> Homo sapiens


      <400> 1683
 atgcgtgatt tgtttggtac gcgattgcga cgtgctgaag acgtatttcc accggtgatc     60
 ggggttgctg cccataaagg tggcgtttac aaaacctcag tttctgttca tcttgctcag    120
 gatctggctc tgaaggggct acgtgttttg ctcgtggaag gtaacgaccc ccagggaaca    180
 gcctcaatgt atcacggatg ggtaccagat cttcatattc atgcagaaga cactctcctg    240
 cctttctatc ttggggaaaa ggacgatgtc acttatgcaa taaagcccac ttgctggccg    300
 gggcttgaca ttattccttc ctgtctggct ctgcaccgta ttgaaactga gttaatgggc    360
 aaatttgatg aaggtaaact gcccaccgat ccacacctga tgctccgact ggccattgaa    420
 actgttgctc atgactatga tgtcatagtt attgacagcg cgcctaacct gggtatcggc    480
 acgattaatg tcgtatgtgc tgctgatgtg ctgattgttc ccacgcctgc tgagttgttt    540
 gactacacct ccgcactgca gtttttcgat atgcttcgtg atctgctcaa gaacgttgat    600
 cttaaagggt tcgagcctga tgatctaaaa aaatcattca agagcccaga acccaggctc    660
 tttactcctg aagaattctt tagaattttt aatagatcca ttgatgcctt caaggacttt    720
 gtagtggcat ctgaaactag tgattgtgtg gtttcttcaa cattaagtcc tgagaaagtt    780
 ctcagggcct catggaaaag agactcggat aattctctta aatcattatc cccaacacaa    840
 atccggctgg gcgaggtgct cacgcctgta atgtcagcat tttgggaggc cgaggtctgg    900
 aattctggtg attctgatga catggctcta gattttgatt gcacatcctc agaggtagat    960
 gctgaaagca caaacagaaa ggtacttcgt ccctag                              996



      <210> 1684
      <211> 582
      <212> DNA
      <213> Homo sapiens


      <400> 1684
 agagcctata ccagttctcc gtggtggaga cagctggacc tggcacactg gtgggccggc     60
 tccgggccca ggacccagac ctgggggaca acgccctgat ggcatacagc atcctggatg    120
 gggaggggtc tgaggccttc agcatcagca cagacttgca gggtcgagac gggctcctca    180
 ctgtccgcaa gcccctagac tttgagagcc agcgctccta ctccttccgt gtcgaggcca    240
 ccaacacgct cattgaccca gcctatctgc ggcgagggcc cttcaaggat gtggcctctg    300
 tgcgtgtggc agtgcaagat gccccagagc cacctgcctt cacccaggct gcctaccacc    360
 tgacagtgcc tgagaacaag gccccgggga ccctggtagg ccagatctcc gcggctgacc    420
 tggactcccc tgccagccca atcagatact ccatcctccc ccactcagat ccggagcgtt    480
 gcttctctat ccagcccgag gaaggcacca tccatacagc agcacccctg gatcgcgagg    540
 ctcgcgcctg gcacaacctc actgtgctgg ctacagagct cg                       582



      <210> 1685
      <211> 582
      <212> DNA
      <213> Homo sapiens


      <400> 1685
 agagcctata ccagttctcc gtggtggaga cagctggacc tggcacactg gtgggccggc     60
 tccgggccca ggacccagac ctgggggaca acgccctgat ggcatacagc atcctggatg    120
 gggaggggtc tgaggccttc agcatcagca cagacttgca gggtcgagac gggctcctca    180
 ctgtccgcaa gcccctagac tttgagagcc agcgctccta ctccttccgt gtcgaggcca    240
 ccaacacgct cattgaccca gcctatctgc ggcgagggcc cttcaaggat gtggcctctg    300
 tgcgtgtggc agtgcaagat gccccagagc cacctgcctt cacccaggct gcctaccacc    360
 tgacagtgcc tgagaacaag gccccgggga ccctggtagg ccagatctcc gcggctgacc    420
 tggactcccc tgccagccca atcagatact ccatcctccc ccactcagat ccggagcgtt    480
 gcttctctat ccagcccgag gaaggcacca tccatacagc agcacccctg gatcgcgagg    540
 ctcgcgcctg gcacaacctc actgtgctgg ctacagagct cg                       582



      <210> 1686
      <211> 839
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(839)
      <223> n = a,t,c or g


      <400> 1686
 aagaatgtct ggaagagatg gaagaaaagg ttttttgtat tggtgcaggt cattcagtac     60
 acgtttgcca tgtgcagtta tcgggagaag aaagcggagc ctcaggaact tctacaattg    120
 gatggctaca ctgtggatta caccgacccc cagccaggtt tggagggtgg ccgagccttc    180
 ttcaatgctg tcaaggaggg agacaccgtg atatttgcca gtgacgatga acaagaccgc    240
 atcctgtggg tccaggccat gtatcgggcc acggggcagt cacacaagcc tgtgcccccg    300
 acccaagtcc agaaactcaa cgccaaggga ggaaatgtac ctcagctgga tgcccctatc    360
 tctcaatttt acgcagatag agctcaaaaa catggcatgg atgaatttat ctcttccaac    420
 ccctgtaact ttgaccacgc ttccctcttt gagatggtac aacgccttac tttggatcac    480
 agacttaatg attcctattc ttgcctgggc tggttcagtc ctggccaggt gtttgtacta    540
 gacgagtatt gcgcccgaaa tggagtccgg gggtgtcacc gacatctctg ctacctcaga    600
 gacttgcttg aacgggcaga aaatggcgcc atgatcgacc ccacccttnt tcactacagc    660
 tttgccttct gtgcatccca tgtccatggg aacaggcctg atggaattgg gaactgttga    720
 ctgttgaaga aaaggaacgt tttttgaagg aaatcaaaag aggaggnttc cgnagttctg    780
 ctaagaaaaa tcaggttaca acattttagg naattgcttt tcccatttgg gtcgaacct     839



      <210> 1687
      <211> 445
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(445)
      <223> n = a,t,c or g


      <400> 1687
 gtcagcttcg gaanttccgg gnagactcac cgcgacggga cttggtgggt tcttggtctc     60
 actgagttct agtttgaagc tgtttaccct cgcagctctc tgactggcac ccctgcctgc    120
 ctgcccggcc ctgcacaaca tgcagccctc cggcctcgag ggtcccggca cgtttggtcg    180
 gtggcctctg ctgagtctgc tgctcctgct gctgctgctc cagcctgtaa cctgtgccta    240
 caccacgcca ggccccccca gagccctcac cacgctgggc gcccccagag cccacaccat    300
 gccgggcacc tacgctccct cgaccacact cagtagtccc agcacccaag gcctgcaaga    360
 gcaggcacgg gccctgatgc gggacttccc gctcgtggac ggccacaacg acctgcccct    420
 ggttctaagg caggtttacc acaat                                          445



      <210> 1688
      <211> 1958
      <212> DNA
      <213> Homo sapiens


      <400> 1688
 caattcccgg gtcgacgatt tcgttttccc tctgttttat ttttcccccg tgtgtcccta     60
 ctatggtcag aaagcctgtt gtgtccacca tctccaaagg aggttacctg cagggaaatg    120
 ttaacgggag gctgccttcc ctgggcaaca aggagccacc tgggcaggag aaagtgcagc    180
 tgaagaggaa agtcacttta ctgaggggag tctccattat cattggcacc atcattggag    240
 caggaatctt catctctcct aagggcgtgc tccagaacac gggcagcgtg ggcatgtctc    300
 tgaccatctg gacggtgtgt ggggtcctgt cactatttgg agctttgtct tatgctgaat    360
 tgggaacaac tataaagaaa tctggaggtc attacacata tattttggaa gtctttggtc    420
 cattaccagc ttttgtacga gtctgggtgg aactcctcat aatacgccct gcagctactg    480
 ctgtgatatc cctggcattt ggacgctaca ttctggaacc attttttatt caatgtgaaa    540
 tccctgaact tgcgatcaag ctcattacag ctgtgggcat aactgtagtg atggtcctaa    600
 atagcatgag tgtcagctgg agcgcccgga tccagatttt cttaaccttt tgcaagctca    660
 cagcaattct gataattata gtccctggag ttatgcagct aattaaaggt caaacgcaga    720
 actttaaaga cgccttttca ggaagagatt caagtattac gcggttgcca ctggcttttt    780
 attatggaat gtatgcatat gctggctggt tttacctcaa ctttgttact gaagaagtag    840
 aaaaccctga aaaaaccatt ccccttgcaa tatgtatatc catggccatt gtcaccattg    900
 gctatgtgct gacaaatgtg gcctacttta cgaccattaa tgctgaggag ctgctgcttt    960
 caaatgcagt ggcagtgacc ttttctgagc ggctactggg aaatttctca ttagcagttc   1020
 cgatctttgt tgccctctcc tgctttggct ccatgaacgg tggtgtgttt gctgtctcca   1080
 ggttattcta tgttgcgtct cgagagggtc accttccaga aatcctctcc atgattcatg   1140
 tccgcaagca cactcctcta ccagctgtta ttgttttgca ccctttgaca atgataatgc   1200
 tcttctctgg agacctcgac agtcttttga atttcctcag ttttgccagg tggcttttta   1260
 ttgggctggc agttgctggg ctgatttatc ttcgatacaa atgcccagat atgcatcgtc   1320
 ctttcaaggt gccactgttc atcccagctt tgttttcctt cacatgcctc ttcatggttg   1380
 ccctttccct ctattcggac ccatttagta cagggattgg cttcgtcatc actctgactg   1440
 gagtccctgc gtattatctc tttattatat gggacaagaa acccaggtgg tttagaataa   1500
 tgtcagagaa aataaccaga acattacaaa taatactgga agttgtccca gaagaagata   1560
 agttatgaac taatggactt gagatcttgg caatctgccc aaggggagac acaaaatagg   1620
 gatttttact tcattttctg aaagtctaga gaattacaac tttggtgata aacaaaagga   1680
 gtcagttatt tttattcata tattttagca tattcgaact aatttctaag aaatttagtt   1740
 ataactctat gtagttatag aaagtgaata tgcagttatt ctatgagtcg cacaattctt   1800
 gagtctctga tacctaccta ttggggttag gagaaaagac tagacaatta ctatgtggtc   1860
 attctctaca acatatgtta gcacggcaaa gaaccttcaa attgaagact gagatttttc   1920
 tgtatatatg ggttttggaa agatggtttt acacacta                           1958



      <210> 1689
      <211> 3395
      <212> DNA
      <213> Homo sapiens


      <400> 1689
 tttagttttg gatacacagt gcacttcatt ccaagagatc ttactagaga tccccgacag     60
 tcagaagatt tcccgcttga tcaggatatt tctcgacgtg tgttattgct ttgcttgtca    120
 cagttttcta gggaaactgg gtgtcagggt aacactccta ggctggcctc ccatgaggga    180
 gttacctcta ggaggcggca ggagttttat ctggcactga aaacttgctg gttggttttc    240
 tagatccatg tttattttca gttcaaagac aaagtagaaa acttgagagt ggaaaatgtt    300
 accttttagt tcacactcct aatcccttag tccccataaa ataaacattc taaagtgtaa    360
 gcagtagaaa taatggaaac tccacagaaa cagaaataaa ttagtttctt tcagtcttgg    420
 tggaggtcct tttgccgaac accatactcc actgtgaaca gaattcatct tgaacgaaga    480
 agaaatcttt ggcctatttc accatgtctc cagcattgca taacagacat ttttcaaatt    540
 cagtttcttc tccaactgca gcaaaaaggc aaagagtagt ctgtttcagg agtctgcatc    600
 gggtcctgtg agagccttgt ccacttagaa caagccttta acttgttctg tttcggtatc    660
 aagatctatg tcataaaagc agggccgggt gggcagtcct ggcatggtgc tcatcgttcc    720
 gaccaaaggg taaatgaacc cagcgcctat gctggcccgg acgtcactga taggtaagat    780
 gaagtccctt ggcacacctt ttttgtcagg ttggtgagat agagaaaggt gggtctttgc    840
 catgcagatg ggcaaatttc caaaaccctg ttgagtgtaa cgatctattt tggcttgtgc    900
 ctcaggagag agttcaatat ctttggctcc atagacagcc tgagcaatgg tccttatctt    960
 gtccacaatt ggaacctgaa catcatacag gaactggaat cggcttcttt tactcgcagc   1020
 ctctctcaca gcccgagcca agtccaccga tccttttcca ccaaccgacc agtgatagca   1080
 ggggactgca tcaaaggcac cagcccgctt tgcaagctca cacaccaagt caatctcagc   1140
 gcgggtgtcg gtcttgaaga cattcagagc caccacaacg ggaaccccaa agagctgagt   1200
 gatctgaatt tgcttctgga ggttacagca gccgtctgcc accagctgga tgttctcctc   1260
 tgtatattct ttcttaagag gaacaccagc cgttacactt ggcccgcctc catgcatctt   1320
 cagagctcgc accgttgcca ctaacacaac cacgttgggc accaagccgg aagctcggca   1380
 cttgatgttg aagaatttct ccattccgat gtcagcacca aagccagctt cggtcactac   1440
 aaatccttct tcaccaacca gtttcagggc aattttatca gccaacactg aagagttgcc   1500
 gtgagcaatg ttagcaaaag ggcccgcatg cacgaacaca ggtgtccctt ccagggtctg   1560
 catcaggttt ggttttattg catctttcat caaaactgtc aaagcacctg tcacccccaa   1620
 atcatctgct gtcacaggct gcccgctttt gtcactggcc accaccatcc ttcccagccg   1680
 tgccttcatg tctgcgaggc tgtccgtcag ggccagcacc gccatgatct cgctggccac   1740
 tgcgatgtca aactgcgcct gccggtaatg gcccttctct gtgtttccct gcccgatggt   1800
 tatttttcgt agaaatcggt catttgtatc caatactctc tgccacgtga tggtagatgg   1860
 gtcgatgtcg agacgggcaa atttactcac ttcctcttct gtcagtgtgc tcggatcagt   1920
 cttatttatt cccagttttt ttagccgagc aagctgaatt tctgaaaatt ctctgacacc   1980
 attcactaaa ggaaccagcc gattatacag agccttatct gtttgcgtgt tttcatgaag   2040
 aatcctcgtg tcgatggcgg cagccagcaa gttattggca gcggtgatgg cgtggatgtc   2100
 tccagtcaag tgaaggttga actcctccat ggggatgacc tgggcatatc caccacccgc   2160
 ggctcctcct ttcactccaa acgtcggtcc ttgggaaggc tgcctcaagc aggcaaagga   2220
 gttgacattc aggtgtgcgg tcagagcctg cacaagcccg atggtgactg tgctcttccc   2280
 ttctccaaga ggggtgggtg tgatcccagc aactaagacg tattttccat ctgcttgatc   2340
 ctttaacctt tctagcacgg acaaacgtac tttggctttg cttttgccat agatttcaat   2400
 ttcatctgca agcaatccaa tctccttggc aaggacatcc acagcttttg gagtttgtcc   2460
 tcttgaaatc tcaatgtcac ttggcacagg ggagagaggc tgaagtttca agcagtgaag   2520
 tctccaccgc ctgtgctgct gttcacgaag ccatctcctt ccactactga ccatgttctg   2580
 aattcgcaga gctgcagcaa ggagaatcac atcatcttcc tcaatgagtc caccaaaatg   2640
 tattcttgga gagccacacc caaccttccc tgacaggaag tcatgggagc agttgagaac   2700
 agtagttcct ggttgtatcc aagtaagggg aatctcttct ggcttaggtg agcctaggac   2760
 cacaatgtca gcctcgtgaa gcttgctttg aagctggcgt gttttccact ggatgctcat   2820
 tgtcatggac ccttttctct ggaacaggca ttgtagagca gcttccaaag acccatgggc   2880
 ccccactacc aaaatcttct ttccatctag gttgacacct gatttttcaa gaagttcaat   2940
 tacagctttg gcaacaggtg aaacaaaaca ttcatgggca tcccctcgca ccagcttccc   3000
 caggtttatg tctgttactc catccacatc tttttctggt ttcaaggcat tgaggacttt   3060
 gttgctaaac aagttctcag agatctgaag ggcaaggcca tgtactctgg tatcttcatt   3120
 gatctttaag atttcatcta taatctcggc ttcactgcta tctggacgcg aggcaaactg   3180
 tgagtgatgt tcagaccagc ctcctcagcc aaatctctgg ttgatttcct agcatcaagc   3240
 ttgtccgtca cctcgcctgg ataacttgca acgaaccgcg cttgaagcgc agcagttttt   3300
 ttcttgccaa taaactatag atacttcttt tgaattctga atgacttctc tgacgacgga   3360
 gtcccgcgcc gcgggcgttc ggccgccggg gctgc                              3395



      <210> 1690
      <211> 6012
      <212> DNA
      <213> Homo sapiens


      <400> 1690
 gagggcgggg aagaggcgtg acggagattc ctgaggtgta gtagcctgag gttcccttat     60
 gtggccctat agctgttact gaaggaagta gcctacgtcc acgcctacaa ctgaagtctc    120
 ttgacaaaca cctcacccct gcctccggga tgaaaggggg taacctagac ctgaatgggc    180
 ttgaccatct cacaactgct cgcgtgacga ccgcattcgt ggcaggtaag aagattgctg    240
 tatcaactca agaaagcagt aacttcactg tctttgtatt ttgaattgca acaacaactt    300
 tgatatcaac aatgaagcaa tgatatctaa gaacaaaaga gtatttgcca acagtcatca    360
 taatatcaag tgattgtata agcagaaaca agctgtcaca gacctgtgcg tcagctaata    420
 tatggagaat gctttcttct gatactattt acttagaggc agttttaata taaatcattt    480
 caattatatc tacatcaaat aaaataaaaa tgagtgaagc ccccagattc ttcgttggac    540
 cagaagatac agaaataaat cctggaaatt atcgacattt cttccaccat gcagatgaag    600
 acgatgagga ggaagatgat tctccaccag aaaggcagat tgtggttgga atatgttcca    660
 tggcaaagaa atcccaaatc ccaaacccaa tgaaggaaat tcttgaacgg atctccttat    720
 ttaaatatat cacattagta gtatttgaag aggaggttat tttgaatgaa ccagtggaaa    780
 actggccttt atgtgattgt cttatttctt tccattctaa aggatttcca ctggacaaag    840
 cggttgccta tgcaaaactc aggaatccat ttgtaatcaa tgacttgaat atgcagtatc    900
 tcatacaaga taggagagaa gtatatagta ttcttcaagc tgaaggtatt ttacttcctc    960
 gttatgctat tttgaaccgt gacccaaata atcccaaaga atgtaatctg attgaagggg   1020
 aagatcatgt agaagtaaat ggggaagttt ttcaaaagcc atttgtagaa aagccagtca   1080
 gtgcagaaga tcacaatgtt tacatttatt acccaacttc tgctggtggt ggaagtcaaa   1140
 gactctttag aaagattggc agtagaagta gtgtttattc tccagaaagc aatgtacgaa   1200
 aaacaggctc atatatatat gaagagttta tgcccacaga tggtactgat gttaaggttt   1260
 atacagtggg tccagattat gcccatgctg aagctcgaaa atctccagca cttgatggca   1320
 aggtggaacg agacagtgaa ggaaaagaag taagataccc tgttattctc aatgcacgag   1380
 agaaattaat tgcttggaaa gtctgccttg cttttaagca aacagtttgt ggctttgatt   1440
 tgttacgggc caatggacag tcctatgtct gtgatgtcaa tggcttcagt tttgtgaaaa   1500
 attccatgaa gtattatgat gactgtgcaa aaatacttgg aaatattgta atgcgagaac   1560
 ttgctccaca atttcatatt ccatggtcaa tacccttaga agctgaagat atcccaattg   1620
 taccaactac atctggaact atgatggaac ttagatgtgt catagctgtt atacgtcatg   1680
 gggatcgaac accaaaacaa aaaatgaaaa tggaagtgag acatcagaaa ttttttgatc   1740
 tttttgaaaa gtgtgatgga tataaatcag ggaaattaaa actcaaaaaa ccaaaacagt   1800
 tacaggaagt gctagatatt gcacgacagc ttcttatgga gctagggcaa aataatgatt   1860
 ctgaaattga agaaaacaag ccaaaacttg aacaacttaa gactgtatta gagatgtatg   1920
 gtcatttttc tggaataaat cgtaaggttc agttgaccta tctccctcat ggttgtccta   1980
 aaacatctag tgaagaggag gacagccgaa gagaagaacc atctttactt ttggttctaa   2040
 aatggggagg tgaattaact cctgcaggca gggtccaggc tgaagaactt ggaagagcct   2100
 tcaggtgtat gtatcctgga ggtcaaggag attatgcagg atttcctggt tgtggtttac   2160
 ttagattaca tagcacctac agacatgacc tcaaaatata tgcctctgat gaaggacgag   2220
 tccagatgac tgcagctgct tttgcaaagg ggcttttagc tttggaagga gagcttacac   2280
 ccattcttgt tcaaatggtg aaaagtgcaa atatgaacgg tcttttggat agtgatagtg   2340
 actctctgag cagttgtcag caacgtgtga aggcaaggct tcatgaaata cttcagaaag   2400
 acagagattt tactgctgaa gattatgaaa agcttactcc atctggaagc atttctctta   2460
 tcaaatcaat gcatttaatt aaaaaccctg tgaagacctg tgataaagtt tattccttaa   2520
 ttcagagttt gacttctcaa atcagacatc gaatggaaga tcctaaatca tcagatattc   2580
 agctttacca tagtgaaaca ttggagctta tgctacgtag atggtccaag ttagagaaag   2640
 actttaaaac aaagaatgga agatatgata ttagtaaaat ccctgacata tatgactgta   2700
 taaaatatga tgtccagcat aatgggttcc ttgaaattag gaaaacacaa tgggaattat   2760
 ataggctttc gaaggcatta gcagatattg ttatccctca ggaatatggt ataactaaag   2820
 ctgaaaaact ggagattgcc aaaggctact gtactcctct ggttagaaaa attcgctcag   2880
 accttcagag gacacaagat gatgacactg taaataaact tcatcctgtg tattctagag   2940
 gtgttctgtc tcctgaacgt catgttcgta ctagattata ttttaccagt gaaagtcatg   3000
 tacattcttt gctgtctatt cttcgctatg gtgccttatg caatgaatca aaggatgaac   3060
 agtggaaacg agctatggat tatttaaacg ttgtcaatga gctcaactac atgactcaga   3120
 ttgttatcat gctttatgag gatcctaata aggatctttc ctcagaagaa cgctttcatg   3180
 ttgaattaca ctttagtccg ggagccaaag gttgtgaaga agacaaaaat ttgccatctg   3240
 gctatggata tagaccagct tccagagaga atgaaggcag gagacctttt aaaattgata   3300
 atgatgatga accacatact tctaaaagag atgaagttga tcgagctgtg atattgttta   3360
 aaccaatggt atcagagcca attcatatac acaggaagtc tccacttcca agatctagga   3420
 agacggctac aaatgatgaa gagagccccc tgagtgtgtc tagcccagag ggtactggta   3480
 cctggctgca ttataccagt ggtgtgggta ctgggcgtcg aagacgcaga tcaggggaac   3540
 aaatcacttc ttcccctgtc tcccccaaat cattggcttt cacatccagt atttttggct   3600
 catggcaaca ggttgtatct gaaaatgcta attacctgcg aacaccaaga actcttgtgg   3660
 aacagaagca gaatcctact gtagggtctc actgtgcggg cctgtttagc acctcggtgc   3720
 tcgggggttc ttcaagcgca cctaacctac aggattatgc tcgtactcat cgtaaaaagc   3780
 tgacctcttc tggctgcata gatgacgcca cacgcggttc tgctgttaaa aggttttata   3840
 tctcatttgc tcgacaccca accaatggct ttgaattgta ttccatggtg ccatctattt   3900
 gtcctctaga aactcttcat aatgccctat ctttaaagca agtggatgaa tttcttgctt   3960
 ccattgcttc tccatcatct gacgttccac ggaagaccgc tgaaatttcc tctacagctt   4020
 tacgttccag tccaataatg agaaaaaaag tatctttaaa tacgtataca cctgcaaaga   4080
 tcctcccaac accaccagct accttaaaga gcactaaagc aagcagcaaa ccagctacaa   4140
 gtggaccttc tagtgcagtt gttcctaata cctcatctcg gaaaaagaat ataactagca   4200
 aaacagaaac gcatgaacac aaaaaaaaca ctgggaaaaa gaaatgaaat cttagcagaa   4260
 gctggaactt tttatactta taaaaatagt atgttcttat gtttctcctt atgcatttat   4320
 gtgttcactt aaaaatgttt ttaaatctaa ggttttcttt gtttatgttc aggtaaggaa   4380
 ctgttgtcat gatctggaaa tgtttaaaac aatgtttgtt agcattctgt gagcagcaaa   4440
 acttatagtg ataaaaatcg attgttgtta atatgatgtt taccatgtgc acatagtaat   4500
 gaaaaggaac ataaaagccc agcaggctcg taccaaagtc acagcagtaa tgctatgtac   4560
 tgcagagtct gatgagctgg cctttgtgca cacttttatt ttcatgggat tgcatcttag   4620
 ctgttaaaac ttctagattg aaatttgaca gccagggtta catattgggg acttttaaag   4680
 tgtctttcca aagagatttc attaaccgtt tagattagaa tatctttccc aattgttaca   4740
 gtgacatata tgctgcaata tttaacaact ggagtattag ccacatgggt tattttttca   4800
 atctgtgttt tgaatttttt tattgtgtgt tatttaaaat attacatatg cagctgggag   4860
 aactacacct ttgtgcacat agatttatat attaatttgt agaaaatatt ttctttatat   4920
 atttccttac catacaaggt gccttgttca tcaggaaaac ttttgttttg tattttgaca   4980
 agaaaggcac cttcagagtt tctttttaag tatagttgac aagtgtataa atgttacact   5040
 tactttcaga gttcttttta gatctaaaga agtcagttca aaaatggaaa tcaacaatgt   5100
 taggagaaat ctgaattctg ttaagttagt aagtattatg tatagcatct gtttttaacc   5160
 atttccattc ttatccctag tgtatcagtt gatcacacta agaaagctta aagattgagc   5220
 atttgaaata aatgctcttt ataaatgatt agatttttga agggatattg aaatcattgc   5280
 gctgtgattt catctgtgat gtgaaaaatc aatttattat ccttggtgct ttccccccca   5340
 ccaatgcaca aataattgtg aacagcttga aatgacttaa actgtaatcc aaatgggaca   5400
 atctgataag aatttcatgc attggtagtt aaataactta aattgctaaa gctttagctt   5460
 gaaatttatg tttagaaaaa ctattgattt cccatggtat gaatataact attgtaattc   5520
 ttcaaatgag actcttctca ccttaaatag tcatatatta attaacttat aggaaataag   5580
 catactatat gttagctgtt ttaaaaggta ccagatgtaa gagtcataaa tatatgcaat   5640
 taaagaagtt catagatttc acatgaatgt aaatgtgtta tatggagaca tgtcttgtaa   5700
 acagttgaat gtatgtaagt tttctgtttg tgaaaatgta gttaatgtac tcactgtgga   5760
 ggtcataagg aagctacttt ttttttaaag tggaacctaa ttaaaatatt tccagaatca   5820
 aaaaaaaaaa aagggggggg ccgtttaaaa gaacccttgg ggggcccaag tttaacgggg   5880
 gatggaaagg taaaattttt tcccttatgg ggggccaaat aaaacccaac ttggaaattt   5940
 tggaaaagaa ccttactttg gggggggaaa catatgggcc caccctcctt acaaaattta   6000
 aaggttttag gg                                                       6012



      <210> 1691
      <211> 552
      <212> DNA
      <213> Homo sapiens


      <400> 1691
 tgtttattga tgatgagttg gccactgagt ggtcactgac tatggagaca ttaactaaag     60
 ttttagctag gaatttatat agtttggatc tcagtgattt accattggat aagctgagtg    120
 aacagaaaca aaaaaagcac aaagggaaag gagttggaca tgaatttcag aaagtttcag    180
 ttgacaagtc attttctaga ggatggagtc gtgatcagcc tggccaagcc ccaatgagac    240
 agaggagtgc aacaaccact ggttctccag gaaccgaaaa ggcgaggagt atagtacggc    300
 aaaaaactgt cgatattgat gatgctcaaa tacttccccg ctcaactaga gtcagacatt    360
 tttcacaaag tgaagaaact ggaaatgaag tttttggtgc tttgaatgag gagcagccat    420
 tgcctcgaag tagcagcact tctgacatct tggaaccatt cactgttgaa cgagccaaag    480
 gtgcagttcc tgtcattgac agttcatccc gtcatgcacc aagcttgcag agtttcacag    540
 aggcttcttc at                                                        552



      <210> 1692
      <211> 1366
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1366)
      <223> n = a,t,c or g


      <400> 1692
 ctcaacccct gaaccactac ttcatctgct cttctcataa cacctaccta gtgggggacc     60
 agctttgtgg ccagagcagc gtcgagggat atatacggtg cagtggtggt agagaagggg    120
 tccaactcat gagagggacc atgtagaaaa gtgaggggag ctgtcagtgt ctaacagatt    180
 gggacagtgt tgtgggggtt taggggctga ggagccctgg ataccagaga cacttggagg    240
 agatattgaa gactggtggg agaatggtaa tgaaacccta tgggtcaatg gaacttctct    300
 ttcacaagct atgaaactct cctggaactc agaggccctg acagatttat atttaacaaa    360
 ttaataaaca gattgttaaa tggaaggcaa tagagaatag gagttaaaaa tataggttct    420
 ggagtcagac catctgaaat tatatcctag ctccttcact tggtactctg gggctaagta    480
 tttaacttct atacctcagt ctccccatct gtgaaacagg gatggtaaca gtgcctattc    540
 tgtctgggtt gttgtgaaga gataattcat atgtcaatag ctaataagca gttctgattt    600
 tattgtgact aatcatggat tagattgaat agtcaagata tctttctatt accagcaact    660
 gaactagtag cttcaaggga tacaaagatg agtggaacat atagtttcca ccttaagaag    720
 tctagctgag gaattaaagg gtaanattta ctgacaggtt gaataacccg gatgttgtat    780
 agggatataa agccagaaac acannnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    840
 nnnnnnncag cacggagaac gtttggaccc cgaatttgga acaagctggg caccattggg    900
 gagccgtttg cccaaaaggc cgaattcccc ggctggggta ggtggtttag taccacgctt    960
 cgggaggggg gggcgagatc ggttaacctg agaggaaggg tgaggtagca cgttgacaca   1020
 cggcctgtca tcggtggagg aatgtaagcg tgttagaagg aaagaggggc gcagtttgat   1080
 gaaacgtgct atggtcgggg tggggatgat attgtatggc gccagtaggt atcgagcggc   1140
 ggatatatgg gagtggggag gaagcgggta gtacgtaacg tagtgagaat gaaggagggg   1200
 agtagcattg gatgatggtg tgtagagtgg gaggtaggta tcgtcggatg gacggaagga   1260
 agggagtgta ggatggtgtg gtaggtatgg aagctacgag aggtgagttg gtaagcacgg   1320
 cacagtaggt gagggaggtt agctagtgag ggaatgtagg gagggc                  1366



      <210> 1693
      <211> 623
      <212> DNA
      <213> Homo sapiens


      <400> 1693
 atggatctct gtcagaaaaa tgagactgac ttagaaaatg ctgaaaataa tgaaattcag     60
 ttcacagaag aaacagaacc aacctatact tgtccagatg gaaaaagtga aaaaaatcat    120
 gtttattgtc ttctcgatgt cagtgacatt acgcttgaac aagatgaaaa agccaaagag    180
 tttattattg gaactggatg ggaagaggca cctccccagc gcagcagccc ggctgtgggc    240
 ctgcggcagc cgggtcttcc tggtccccac ctcctggggc cgacgggcgg caggaagggg    300
 ctcggcggga cgcgccatca gggacctgag gaggaacaac ggaacgcgtt cggaacggcc    360
 tggactcccg agactcaccc gactcgtggc cacaccggga gaactgaagc ggcagtagcc    420
 ggcggagacg cccgacccga aggccggctg ctagggagca gacagctgaa ccgcttgcca    480
 gacgccgaaa cccagtgacg ccctacaccg ctgcaccgag ctcccggttc cccgaccccg    540
 gcgcccgcgg gccccaaggc gcatgcgccg cctgtcctgg aggggcccat ttccttccgt    600
 cgtgtgggga ggcacagtga gtc                                            623



      <210> 1694
      <211> 1315
      <212> DNA
      <213> Homo sapiens


      <400> 1694
 tcataaagcc ctttctactc ccagcactct cttcaaagta ttcttcactt ctgagttcct     60
 aagactacag ataaggggat tgagcatggg attaaagagg ctgtgaaaca gcaggagata    120
 tttcttctgc tccttggggt tcccatatct gggtccaaca tacatgataa tggctgtgcc    180
 ataaaagagt ccaatcacac agaggtggga gaagcaggtg cagaaggctt tcctctgaac    240
 ttcccttgat tggatctgaa ggatagcaca gaggatgcac atatatgaaa ctacaattgt    300
 ggacaagggt cccaccagcc cagaaattgc tccggccaag accatgttct cattgatgtg    360
 ggtatctgca caggcaagtt tgagaacagc caagatttca caaaaaaagt gataaatttt    420
 ctggggccta cagaagggta aaggtagaag taacacaaga tgaatcaagg ataaaaggac    480
 tccagtggtc caggaagtca ccgcgagggt gatgcagact ctccaggtca tgatggccaa    540
 atatcggagg gggtggcaga tggcccacgt acagatcata ggacatcacc accaggagga    600
 gacattctgt gacagcaaaa gtggaaaaca gaaaggtctg catcatgcgg cccgcaaagg    660
 agatgggctt ggctggatgc aggaggttca ccagcatccg gggcaccgtg ttgcaggcgt    720
 aggcgatgtc gacgaccgcc caggtgtgag aggaagaagt acatgggggc gtgcagtctg    780
 gagtccagtg agatgagccc cagtatggtc ccgttcccca gcagggtgaa gacgtagaac    840
 agggagaaga gcccaaagag gagcatctga atccttgggc caacgggaaa tcccagtagg    900
 aggaactctg tgatggatgt tatattgtcc cccatatccc tatgacagag gaaatcaagt    960
 taatgctcat ggtttaggag aagtgtttaa aaacagattc attttaactt gttcggcact   1020
 ctttggtgaa gtagaaaagt gttcagacag ctgcagtgag tttttgtgtt tttaaatgaa   1080
 tgcttcaaga caatttggta acgctaaaat aaatgtttaa aaaatatatg caggccgggt   1140
 gcggtagctc acgcctgtaa tcccagcact ttgggaggcc gaggcgggcg gattgcctga   1200
 gcttcaggag gttgagacca tcctggctaa cacagtgaaa ctcccgtctc cactaaagca   1260
 caaaaaattt agccggcgtg ggcgcatgcg cctgtatccc agctacctgg gattc        1315



      <210> 1695
      <211> 1306
      <212> DNA
      <213> Homo sapiens


      <400> 1695
 tttttttttt ttaaaaatga tctcttctcc tttattgcca cattcacata aaacgttttg     60
 atatatttgg gttggtaaaa gctaaagaaa attgaagtta aaatatatat ggttttagtg    120
 ttccgaaaag cagttacaga ttgcttcctt ggtttaatta tcgaagcggt cgaaattctg    180
 ggtttgaaac tcttggaagt cctcagggat ggtgtcattg cagcgatact tgaggttgga    240
 ccagatgatg ttttcttgag agaagcagaa aacgccaagt cggcctccac gcattgtggt    300
 gtctatggtg acgccagagt cagccaccaa ctcagagcct tcataaaatc gtaccctgat    360
 gtagcccacc tggggcctgt gctgtaggaa ccagcggtag gacaccttgt ccttccagcc    420
 cacattcctg gagtccttcc acagcagcct gacctggtca ctggtgtccc ccgtgtgcca    480
 cagggagttc cggagatgct cccctggacc tgtcttagac ttcacagcct tgagctgaat    540
 gccaggttct gcaactgctc ggaatggggt ggcttgccaa tatgtctgct ccgtctgctt    600
 ccacatgacc acgtagaagc tggagctatc ttggtagcca aagataaagc ctgcatagtc    660
 atcatctgtc tgggtattca catggaaggt cccttcgaag tcaactccat taaaaagctg    720
 tgtaccccac tgccaggcca ggatcactgt tcatggtctg tacaatctcc atgccctggt    780
 tcaggaccac ccagttggga tcgatctggg catccccttc aggatccagg accacggtct    840
 ggtaagccct gaagtcggtc agggtgacct ctgcgttctc tgggcagacg tcgatccgat    900
 cgatgacctg gtcctggtca aagtcagact cacagatgtc tcccactccg tcgctgttgc    960
 tatcctcctg ggctgggttg gggaccagcc ggcagttgtc tggtccaggg ggcaccaggt   1020
 ctgggatacc atcattgtca tcatcatcat cacactcgtc accaattcca tccttatcgg   1080
 tgtccagctg ggcactgtta atgacggtgg ggcagttgtc tgtgctgtcc tggtgcccat   1140
 ctccatcact gtcctgattg gtgtcacagg agtccccaac cagatcatta tccacatcag   1200
 actggttagg gttgctgaca tcaggacaac tgtcacaggc atcccccaca ccatcaccat   1260
 ccttgtcccg ttggtcacga ttgggaaatt ttgggcagta cgaaat                  1306



      <210> 1696
      <211> 4700
      <212> DNA
      <213> Homo sapiens


      <400> 1696
 tttttttttt tttaagtcag aaacaggaaa cgtttattta aatagtgtag tcttaatttc     60
 tttaatataa aaccccccca aatctgatga aaacaaagtt ttatatacca tataaacaag    120
 atttgtcaga tttgaaagtg aaagttaaag taatttacag ttagctttta accctctcgg    180
 gacatttaga tacatcctcg ataatccatc ttgtaattag tgtgtgtcaa ttttacaata    240
 cactggggga aaactcaggc tattgtattt aacgggtaca gtttcattta tcaaagtgtt    300
 tcccattaat tcccattatt aggtggacag ctaaccaagt gaccccatca aaatgaagtg    360
 aatgacatta gactgtggcc agagtgaacc acatctggga ttggctttct ataattcacc    420
 cagtttgcgg ggaagtaaac attctttgga tttgttcata atatactgaa gttacctata    480
 acactggtgc agtaacacag ctagttcctc tgtattggtt atgggtaaga acgggatttt    540
 ggtaatataa agttaacagg aaaaaaatgc ttcacacatt atgtggtgga aacttatctc    600
 cacaaaaaga ccattaaaat aaaaaggata gagggaaaaa taaaccatgc agaagagacg    660
 gcttccccca tcttccaacc tgtttcccat gggctcactc attgcccata catcacttgc    720
 cacactatca agtgactcct ttctgctttg gtgacagaag gttcaagtgg aagatcctct    780
 ccaagaagtt ctgattctcc accttcatca cccattcgga agtcgatgta gccctctcct    840
 ccactgatga caagcataga cttcaagggc gtctgactac caggctcctg tgcagatggc    900
 ccctgccttt gtcacccgtc agatccgtgc cactactgct actttgtggg ctgatgactt    960
 gacctgggac tgccacaaag aatttcacag catcccggtg cccatggaag caaagctgtg   1020
 catgtgccat tgaacaatag ggtataaatg tccctggagt cactttatca ctgttttcat   1080
 caccatatac acggattaca cttccaggac gatttcctgg tacacctgag gttttatttg   1140
 ccctcagccc cagtaaacgt ccctggtgga ggattacggt ttctgtcaat gggatggaga   1200
 taatgacacc atttcctgtc cccacccaca aacgattaca agacaccata agagctgtaa   1260
 ttctcacaaa agagaagccc agttttccag tacctaacat tttgcttaca taaggctcaa   1320
 tgtccacatc ctgtagatgt tgataagtgt gtgcatgata gagacggagc gtagaatcca   1380
 agcgaatgga gacccacacg ccatccccca cccacgcaag ctgtcgcact tggctctcct   1440
 tcctgggatg tgcatcaaaa gatttctcta ttttcatggc ctttggctgc accacataga   1500
 ttttgttcct atagccacac cagactttgt catgtaccac agtcatgcaa cggatggaat   1560
 gatgaggccg tccaaggtct aagaggtgat agtttgacaa atcccactgc ccatccactc   1620
 ctctgtgaaa gattgcaagg gtgccgtcag ccagggctac taacacgatt cccttcacgt   1680
 gtacaatact gagaatcgaa tctttaagtt taatggaatg gagacatttc ctccactggg   1740
 ctacagatga atggacatac aaacagccat tttgagctcc aagccacata gttggtaaaa   1800
 gactactcat tttctgggct tcttctctca ccaagtcttg ttcatttggc agtactgata   1860
 tttgatcttt atatgcatct gagtcattgc tcgactgata cactggggag aggtcttctg   1920
 ggatctgaac ttcccaaagg atctgtaaag acatgctctg tgtagacgcc agtttgggag   1980
 atgtccaact gtgtcttcag ctgaccccgc attcccttct gtagcttcag ttgctttctt   2040
 ctgctgttgg aacattttca tcaacctcac tattttctgc ttccatttct ggtggtttat   2100
 ccatcactgg agaagcacca tttgtactag gggaagtggc agctcccgtc acaccttctg   2160
 cagaacaacc aaccactgtg atgcctccta acaggctgtc tgtctctgct gagctgttgc   2220
 ttgtcatact tccacataaa gatgctttgt ctacctgacc agattctgaa agatcttctc   2280
 ctgcagggta gtctgtttct cgtgcacctg gcacacttgc aatgcacaga acatgagagt   2340
 tgcaaacagt gaaactgtct aggatgttgc caggttgaac agcatcaata ataagaactt   2400
 ttgtagccga atgagtgctg gtacagatcc aaactagact ggataattct tcttgatttt   2460
 ttaactcctt ctgctgttcc ttaagttcct gatctaactt atctaaacta ctctgagagg   2520
 cacttcgctg tttactgcct tctgtatcca aaccagcaac atccttgtaa aatacacttg   2580
 ctccaacaac agaaccacca tctctggtct tcccaccaga taaattgact ccaacagcac   2640
 accacagctt cattgatgta tcttttttat ccagaggtct gagatagaca ggcacaggta   2700
 aatttttcat cttattttca ccttgaccat tggttacctg tttgtacttc tgaggcagac   2760
 tccagccaaa agcctgcact ctaccgtctt ccttctgaac atgtgctttt acctgacgat   2820
 actgctctct cttttgttct ctgcgtgagg ctaaactagc ttcagtttct tcactaagga   2880
 aatcaaaggc tttggactta tccccaggga gctgagataa ggtgctgctt cttttcttga   2940
 cggacggagt aacatgagac gtgggtgcat tgtacttcag attaacaggt ggttcaggct   3000
 tcttagtcgt gttacttgag gagctgaaaa gtcggctaaa aaactgccaa atgcttgacc   3060
 tttttttttc ctgcatggct ggattttctc gtgatgcccg aatcatctct gtccatcgaa   3120
 cagcttcctg aagctccatc aatctctctt tatactggtt tcgctccatg agaacacggg   3180
 ccatttctac tctagtaaac cgtttcctct gggctgtggg aatatcacta tcatcgtcat   3240
 cttttgcttt ttgccttgca tcttcagctt ctgcccgagc tttcctaagc tcttcctcca   3300
 attctctgtt cttttcctct agtttcagtt tggcttgctt cacagcctcc aattcccctt   3360
 gcagcacatc tttctcacag gtcagttcat ccacttttgc tatcaaatca ttcttcacta   3420
 tgttcaaagc atttttggtt tccaacagtt gtgtattttc taatataaga ttctcaactt   3480
 cccgacccat tcctagtaaa tctgctcctt catccacatc tcctattagg cctgagccag   3540
 ctgaagacag ttcttcaaag agagattctg tattgcgatc aaaagctttg ttctctatgc   3600
 ctttggtggg agtgcttgaa cctttatatc cactgagatc tttgtccata tccagctcag   3660
 gagtagattc gatgattgct tgaacttctg acttttcttc attttcagca gagccagtag   3720
 atacatttct agtttcctgg gctacctgta cttcaatgtg tttgcttatc tctgatttat   3780
 ttggcgcatc tgtaaccttc acaaatcctt cgttttcttc ctttaaggga gtatcagtag   3840
 gaattgttgc cacatctgaa ttagctgttg atgctggagt ggtagcttta gatccgcctt   3900
 ggctaacatc agaaagctca tccttcaggc tggtatgaga acgtggttga cttaattcct   3960
 gaaatttcca ttgctcagat ccaggggtct ctcctccttt ctgagcatca ggtgtaagca   4020
 atccatctcc agcaggtaat gggaaaattc ctaatgatat agggcgttct tttctaattc   4080
 tactatgagc tgtggattct agttgatcac tccctgagag ctgatgaagt tttgttcttt   4140
 ctaaatgttc catataatta tggatcatct cagtgtgtct ttgatgtaat gcattatatt   4200
 ccttcttcag ttctgcttct ctttcttcaa gtatgctaat ctggtcagca tagtttttcg   4260
 ctttcagctc aagttgtctt gtttgagatt ctaaagattc cactcgggtc tgtaagtcct   4320
 ttttttcctg ttcttgagag tcttcaaatt caatgaattt ctcctcagcg tgcttgcgca   4380
 gcgccttctc tcgctcgtac tgggtgatga gctgctcgtt gtcgtcccgc agcagctcca   4440
 gctccacctg gtgctcctgg tcctgcgcga acaccgagtc caggttctcc agcacagcca   4500
 ccaccagcgg gatcagctct ttgaccacct cctcgtcata gcgcacgata agccgctcga   4560
 actcgcggta gatggagccg gccaggccgg acacccgctc cgacatcacg gccccggagc   4620
 cgccgggctc ctcctgatac accacaccgt cctccagctc catggttggc aagcggacgg   4680
 gcgggcggcc cggggcgtcg                                               4700



      <210> 1697
      <211> 2685
      <212> DNA
      <213> Homo sapiens


      <400> 1697
 gcggccgcgg cggcggctgg ggcgttcgcg ggccggcgcg cggcgtgcgg ggccgtgctg     60
 ctgacggagc tgctggagcg cgccgctttc tacggcatca cgtccaacct ggtgctattc    120
 ctgaacgggg cgccgttctg ctgggagggc gcgcaggcca gcgaggcgct gctgctcttc    180
 atgggcctca cctacctggg ctcgccgttc ggaggctggc tggccgacgc gcggctgggc    240
 cgggcgcgcg ccatcctgct gagcctggcg ctctacctgc tgggcatgct ggccttcccg    300
 ctgctggccg cgcccgccac gcgagccgcg ctctgcggtt ccgcgcgcct gctcaactgc    360
 acggcgcctg gtcccgacgc cgccgcccgc tgctgctcac cggccacctt cgcggggctg    420
 gtgctggtgg gcctgggcgt ggccaccgtc aaggccaaca tcacgccctt cggcgccgac    480
 caggttaaag atcgaggtcc ggaagccact aggagatttt ttaattggtt ttattggagc    540
 attaacctgg gagcgatcct gtcgttaggt ggcattgcct atattcagca gaacgtcagc    600
 tttgtcactg gttatgcgat ccccactgtc tgcgtcggcc ttgcttttgt ggtcttcctc    660
 tgtggccaga gcgttttcat caccaagcct cctgatggca gtgccttcac cgacatgttc    720
 aagatactga cgtattcctg ctgttcccag aagcgaagtg gagagcgcca gagtaatggt    780
 gaaggcattg gagtctttca gcaatcttct aaacaaagtc tgtttgattc atgtaagatg    840
 tctcatggtg ggccatttac agaagagaaa gtggaagatg tgaaagctct ggtcaagatt    900
 gtccctgttt tcttggcttt gataccttac tggacagtgt atttccaaat gcagacaaca    960
 tatgttttac agagtcttca tttgaggatt ccagaaattt caaatattac aaccactcct   1020
 cacacgctcc ctgcagcctg gctgaccatg tttgatgctg tgctcatcct cctgctcatc   1080
 cctctgaagg acaaactggt cgatcccatt ttgagaagac atggcctgct cccatcctcc   1140
 ctgaagagga tcgccgtggg catgttcttt gtcatgtgct cggcctttgc tgcaggaatt   1200
 ttggagagta aaaggctgaa ccttgttaaa gagaaaacca ttaatcagac catcggcaac   1260
 gtcgtctacc atgctgccga tctgtcgctg tggtggcagg tgccgcagta cttgctgatt   1320
 gggatcagcg agatctttgc aagtatcgca ggcctggaat ttgcatactc agctgccccc   1380
 aagtccatgc agagtgccat aatgggcttg ttctttttct tctctggcgt cgggtcgttc   1440
 gtgggttctg gactgctggc actggtgtct atcaaagcca tcggatggat gagcagtcac   1500
 acagactttg gtaatattaa cggctgctat ttgaactatt acttttttct tctggctgct   1560
 attcaaggag ctaccctcct gcttttcctc attatttctg tgaaatatga ccatcatcga   1620
 gaccatcagc gatcaagagc caatggcgtg cccaccagca ggagggcctg accttcctga   1680
 ggccatgtgc ggtttctgag gctgacatgt cagtaactga ctggggtgca ctgagaacag   1740
 gcaagacttt aaattcccat aaaatgtctg acttcactga aacttgcatg ttgcctggat   1800
 tgatttcttc tttccctcta tccaaaggag cttggtaagt gccttactgc agcgtgtctc   1860
 ctggcacgct gggccctccg ggaggagagc tgcagatttc gagtatgtcg cttgtcattc   1920
 aaggtctctg tgaatcctct agctgggttc ccttttttac agaaactcac aaatggagat   1980
 tgcaaagtct tggggaactc cacgtgttag ttggcatccc agtttcttaa acaaatagta   2040
 tcacctgctt cccatagcca tatctcactg taaaaaaaaa aattaataaa ctgttactta   2100
 tatttaagaa agggaggatt tttttttttt aaagataaaa gcatggtcag atgctgcaag   2160
 gattttacat aaaggccata tttatggttt ccttcctgaa aacagtcttg ctcttgccat   2220
 gttctttgat ttaggctggt agtaaacaca tttcatctgc tgcttcaaaa agtacttact   2280
 ttttaaacca tcaacattac ttttctttct taaggcaagg catgcataag agtcatttga   2340
 gaccatgtgt cccatctcaa gccacagagc aactcacggg gtacttcaca ccttacctag   2400
 tcagagtgct tatatatagc tttattttgg tacgattgag actaaagact gatcatggtt   2460
 gtatgtaagg aaaacattct tttgaacaga aatagtgtaa ttaaaaataa ttgaaagtgt   2520
 taaatgtgaa cttgagctgt ttgaccagtc acatttttgt attgttactg tacgtgtatc   2580
 tggggcttct ccgtttgtta atactttttc tgtatttgtt gctgtatttt tggcataact   2640
 ttattataaa aagcatctca aatgcgaaat ccatgaaaaa aaaaa                   2685



      <210> 1698
      <211> 972
      <212> DNA
      <213> Homo sapiens


      <400> 1698
 ggttttgcct taggttgaag ctttctaacg aggagatccg gcaggccatc ttgaagatgg     60
 atgagcagga ggaccttgct aaggacatgc tggagcaggt gaggaccctc gtgggaagga    120
 aggggaactg aacccagcgg gcagccacgc cccttcccaa cagcccccag gaggctgcga    180
 ttcttgggtc aaggagaaat caggctggaa gagttaggga gaaggtttat agaagcctcc    240
 ctgggccggc ctttcttggg gaaagctgga aaaggctaag tgttctccag gagtcattct    300
 cccatctgac tccaaggcaa agtcagatga ggaaaagtga catcttcccc aaatctcttc    360
 cctctcagtt ttttggatcc tttgggaaac cagttgcttg tgtgacttgc gcctgctctt    420
 tgcagctcct caagttcatc ccagagaaga gtgacattga cctccttgtc tacaggattg    480
 accactacca gcagcgactg caagccctct tcttcaagaa gaaattccag gagcggctgg    540
 ctgaggcaaa gcccaaagtg gaaggtaggg ctgagggttg caggaggctt agagtggaga    600
 gttatctgat catgatcctg gagaagcatt ttcctgatat tctaaacatg ccttcagagc    660
 tgcaacatct tccagaagcc gccaaagtca agtgagggtt ctctccaaga cttccttctc    720
 cccatgatga ccctcattct tgtcttactt tcctcttttg gggtctactc tgggcttgat    780
 gatggctggt gtgagacctc ggttcttgtc ttctgagttc aaaagaattt aaacagacac    840
 acagcaaagg gggtttagca tagaacaatg tattgcaaaa gaagatatct tgtgagttag    900
 gtgcagaata gacagtacac cctgagagag agaggattca gggtgggctg cttgtaagga    960
 attacaccgc ac                                                        972



      <210> 1699
      <211> 508
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(508)
      <223> n = a,t,c or g


      <400> 1699
 tgaatgtaag aaatgtcaga agaaatttag tagtggttat caacttattc tacatcacag     60
 ggttcatgtc attgagagac cctatgaatg caaagagtgt gggaagaact ttcgtagtgg    120
 ctatcaactt actctacatc aaagatttca tactggtgag aaaccctatg aatgtacaga    180
 atgtgggaag aactttagaa gtggctatca gctgactgtg catcagagat ttcatactgg    240
 tgagaaaacc tatgaatgta cgcagtgtgg gaaggccttt atatatgcct cacacattgc    300
 tcaacatgag agaattcaca ctggtgggaa gccgtatgaa tgtcaggagt gtgggagggc    360
 ctttagtcaa ggtggacatc ttagaattca tcagagagtt catactggcg aaaaaccata    420
 taaatgtaag gagtgtggga agacttttag tacgcgctca natcttgttg aacatgggcg    480
 agttcatact gatgagaagc catacatg                                       508



      <210> 1700
      <211> 449
      <212> DNA
      <213> Homo sapiens


      <400> 1700
 tttcgtagcg agctgagctg acagcgcgga gctggcgctg tggagcgcag ggagccttgc     60
 tggttcctcc gaccggcgtc tgcgagtaca gcggcggcta acctgccccg gcttcaggat    120
 ttacacagac gtggggcgat gcttgtgacc ctgcagctcc tcaaaggccc ctagaagcct    180
 gtttctccgt acagtccagg acctccagcc ccatggagcc cccgatccca cagagcgccc    240
 ccttgactcc caactcagtc atggtccagc cccttcttga cagccggatg tcccacagcc    300
 ggctccagca cccactcacc atcctaccca ttgaccaggt gaagaccagc catgtggaga    360
 atgactacat agacaaccct agcctggccc tgaccaccgg cccaaagcgg acccggggcg    420
 gggccccaga gctggccccg acgcccgcc                                      449



      <210> 1701
      <211> 3771
      <212> DNA
      <213> Homo sapiens


      <400> 1701
 tttcgtagat caggaaaagc aatacttaaa ttcacttctg agccgaaact gggcattttg     60
 ggggatgggc atggcaaaca gcagtagagt tctttaggaa aaaattaggg acgttttcag    120
 cagctcccgc cacctactat gtccgggcta ctgcgggatc cacagaatgg aagctgcccg    180
 ccaacaggaa gaatgtctcc tccctctgca gggcttcctt tcccccatcg agggcccctg    240
 gggaccacag gtccccagcg ggtagggcgg aggcgtggcc ttgcgaaggt cagcggaggc    300
 cacccagagc tcacagcctc ctgccagcgc gctctctgtt tctctgcagc cccgaagctc    360
 gcgaatgtag caggcgcccc aagctcggtc ctcaagaagc catggcggaa tccaggggcc    420
 gtctgtacct ttggatgtgc ttggctgctg cgctggcatc tttcctgatg ggatttatgg    480
 tgggctggtt tattaagcct ctcaaagaaa caaccacttc tgtgcgctat catcaaagta    540
 tacggtggaa actggtatcc gaaatgaaag ctgaaaacat caaatcattt cttcgttctt    600
 ttacaaagct tcctcatctg gcaggaacag aacaaaattt cttgcttgcc aagaaaatcc    660
 aaacccagtg gaagaaattt ggactagatt cagccaagtt ggttcattat gatgtcctct    720
 tatcttaccc caatgagaca aatgccaact atatatcgat tgtggatgaa catgaaactg    780
 agattttcaa aacatcatac cttgaaccac caccagatgg ctatgagaat gttacaaata    840
 ttgtgccacc atataatgct ttctcagccc aaggcatgcc agagggagat cttgtatatg    900
 tgaactatgc tcgcactgaa gactttttca aactagaaag agagatgggc atcaactgta    960
 ctgggaagat tgttattgca agatatggaa aaatcttcag aggaaataaa gttaaaaatg   1020
 ccatgttagc aggagccata ggaatcatct tgtactcaga tccagctgac tactttgctc   1080
 ctgaggtaca gccatatccc aaaggatgga atcttcctgg aactgcagcc cagagaggaa   1140
 atgtgttaaa tttgaatggt gctggtgacc cactcactcc aggctatcca gcaaaagaat   1200
 acactttcag acttgatgtt gaagaaggag tgggaatccc ccgaatacct gtacatccca   1260
 ttggatataa tgatgcagaa atattattac gctacttggg aggaattgct ccaccagata   1320
 agagttggaa gggagccctt aatgtgagtt atagtatcgg acctggcttt acagggagtg   1380
 attctttcag gaaggttaga atgcatgttt ataacatcaa taaaattaca aggatttaca   1440
 atgtagttgg aactatcaga ggatctgtgg aacctgacag gtatgttatt ctgggaggtc   1500
 accgggactc ctgggtattt ggagctattg acccaaccag tggggttgct gttttgcaag   1560
 aaattgcccg gagttttgga aaactgatga gtaaaggctg gagacctaga agaactatca   1620
 tttttgccag ctgggatgca gaagaatttg gacttctggg ttccacagaa tgggctgagg   1680
 agaatgtcaa aatactccag gagagaagca ttgcttatat caactcggat tcatctatag   1740
 aaggcaatta tactctcaga gttgactgta ctccccttct ttaccaatta gtgtataaac   1800
 tgacaaaaga gatccccagc cctgatgatg ggtttgagag taaatttttg tatgaaagct   1860
 gggtggaaaa agacccttca cctgaaaata aaaatttgcc tagaatcaat aagctgggat   1920
 ctggaagtga ctttgaagct tattttcaga gacttggaat tgcttcaggc agagcccgtt   1980
 acactaagaa taagaaaaca gataagtaca gcagctaccc agtgtaccac acaatttatg   2040
 agacatttga attggtagag aaattttatg accccacatt taaaaaacaa ctttctgtgg   2100
 ctcaattacg aggagcactg gtatatgagc ttgtggattc taaaatcatt ccttttaata   2160
 ttcaagacta tgcagaagct ttgaaaaact atgcagcaag tatctataat ctatctaaga   2220
 aacatgatca acaattgaca gaccatggag tatcatttga ctccttattt tctgctgtga   2280
 aaaacttctc agaggctgct tcagattttc ataaacgact tatacaagtt gatcttaaca   2340
 atcccattgc agtgagaatg atgaatgacc aactgatgct cctggaaaga gcattcatcg   2400
 atcctcttgg tttaccagga aagctgttct ataggcacat catatttgct ccaagtagcc   2460
 acaacaaata tgctggagaa tcatttcctg gaatctatga tgctatcttt gatattgaaa   2520
 ataaagccaa ctctcgtttg gcctggaaag aagtaaagaa acatatttct attgcagctt   2580
 ttacaattca agcagcagca ggaactctga aagaagtatt atagaaggtc tcaagtggct   2640
 agccattaaa ggtgttgcta aaagtctgag gataaaattc acctttctga taacttatga   2700
 agccagggtg ttctaaactc ttttcatgtc atgttttgat tataggcttt ggtcttttca   2760
 tctgcaaagc cttttttttt tgctctttaa aagttaataa ttatattagc aaagggttaa   2820
 tctaatgaag taaaaaactc ctgtgtggca gaaagtaaaa gaaaattccc taaattatag   2880
 caaggaacat gaattctcag acattgtgag tgtgggaatg taaaatggta aaatcacttt   2940
 tgaaaacagt ttggcagttt cctataaagt taaacataca cttttacttt aggactccag   3000
 aattccactt ctagttattt attcaagaga aggaaaaaca atgatcacag caatacttgt   3060
 atgcatgttc attgcaactt aaaagcgtaa aaaccccaaa tgtccatcca cagacgaatg   3120
 tataaactgt ggtatccatt acacaataga ctacttacta ctcagcaata aaaatgaagt   3180
 aactttcaat aaatgcaata ttattggcag acattgttga aggaaaaaag ccagacaaac   3240
 aacctacata aaatatgttt ctatttagat gaagtggcaa actaatctgt agtgttaaaa   3300
 attagattag tgattgcctg ggccaagtgg caggttgggg aggatggctg caaagaagta   3360
 tgaggaaact ttctccaata gatgagaatt ttccgtatct tgatctgagt ggcaaattgt   3420
 aaacttaaaa tatatataaa atttattgta tgaaaattaa gcctcaataa acgtgattat   3480
 aaaaaacaag tctgcaagga aaccagaatc atataccttc tcttgtgaaa tcaccatgaa   3540
 gtgtgaatgg tcaggaaaaa gccagtaata ttcatacatt taataatttc agctctactg   3600
 aataaacata taagtctgat gggtgatgaa aatagctact acaatcttca tattctaact   3660
 cctataaaga ctgtatatca gaatctgcaa acttttatgc agatcccagt gactcaatta   3720
 catgttcaac tatgattaaa gcttcaataa acttggttgt tcatctactt c            3771



      <210> 1702
      <211> 603
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(603)
      <223> n = a,t,c or g


      <400> 1702
 gtccggactt cccgggtcga cgatttcgtc ggcggtgctg gtggtgctcg gcggccggag     60
 ccggatcctg tagccgggtg tgggcccgtg tctgtccgtc cctccttcgg ccccctctct    120
 tgtcttccgg agtgtggctg gcggagctgg gatggcggaa cgaggcctgg agccgtcgcc    180
 ggccgcggtg gcggcgctgc cgcctgaagt gcgggcgcag ctggcggagc tggagctgga    240
 gctctcggag ggggacatca cccagaaggg ctatgaaaag aaaaggtcca aactcctatc    300
 tccttacagc ccgcagacac aagaaactga ttcagcagta cagaaagaac ttagaaacca    360
 gacacctgct ccatctgcag ctcaaacttc tgctccctct aagtaccacc gaactcgatc    420
 tgggggagcc agggatgaac gatatcgatc aggtgaggag aagctgcaga atggccagct    480
 gaatcgtttt cctaacagta gtatgaactg tgtatcctga gagcttctaa tacttgnnnn    540
 nnnnnnccct atgaggcacc aacagtttta tattaactca ttcaccaatc attaattttg    600
 tac                                                                  603



      <210> 1703
      <211> 6329
      <212> DNA
      <213> Homo sapiens


      <400> 1703
 tttttttttt ttcggagtga aaaagacgct gtatttgatt tacaatgaac aagatttaca     60
 aaaaggggtg gggtggtctt ggaactgctc ccagtccccc cggactgggt ggggctctag    120
 ggcagcctgt ctgacagacc aggaccccag gatgtctggg ccccgacgta ggacttgacc    180
 tacgtctcac ttgacctttg acgtggggcc cagcagccgt gagtccaccc agagtgccgg    240
 cacccttggg gaggccggtg aggtcaggaa ggcatcgtac cgctttttct cctcctccca    300
 tctcgtggtg gacagacaga cataggatct gggaacttgc cctgggggcc acaggccctc    360
 agatccccca ggggcccaac ctagggcatg gaggcggctg ctggtgcgtg ggcggaggcg    420
 gaggccagct gcccccagcg tggcagcgta aggcacattt tcaaatcact cgagactcga    480
 cagtgaacac ccgatgctgg ttctgcggcc ggagggagct ggggctgggg ctggtgctgg    540
 tgcggtgccc ggcggtattg ctcagaggaa gatgctacag tctagacgct gggcgggttc    600
 cggctgcacc cactccggct tggggcgcgt tccaggggag ggtgggggcc tcagccacag    660
 ccactcggcc tcctcccctg aggggctctc aggtacctca ggtacctatg tcccaaggca    720
 gcactggaga ttgtaggtca gaggtcagtg accttgttct ccagtgcagc ggcaatctgc    780
 tgcaggcgga aggccagctg catcttctgg gcggcaggat cctcctccaa ggcattgatg    840
 atctcgtcat agtacttctg cgtgtattgg tagagctggt ggagtgccac gagggtgttc    900
 aaggagtccg tgtgcgcccg ggaaatctct gccaggtgtg tgttcatgtc ctggtcgctg    960
 acctgcacca tctgccggat ccccttgtag taatcctcca ccatcttctt gtaggtggag   1020
 atctccttgg cgtacagcag cttgttgctg ggagaatcgc ggctcagctt atgctccgtg   1080
 cgcgtgcagg catccatgaa ggtctgcgcg atgactgaca gcgaggcgtc caccacctcg   1140
 tggacatgca cgtcaaagat gaagtggggg ttcttgagga tgttcaccca gaaccggagc   1200
 ggtaaactgt tcgtcttcca gatgtggatg gtgtcttcat cctggatgtt gtgcttctct   1260
 gcctgctcgt ccaggaagtc gaagaagtac ttgactgcag gtggcaccgc gtgcccaggc   1320
 gccagcacgc tctggaagaa gttgtccaca aactgctgca gtgtgccctt gactgagagc   1380
 agccgcgtca ggtagatctc ggtgatggcc ttcgtccgct ccttctcttt cacgctgcct   1440
 ctcttggact tgccctcgtc cacctcgtcg gtcggccgca ccaggtgcca cacccggttc   1500
 tcctcctcca ggagggcatg gcgctcccca ggcaggtcct gctggctgtc ctccggctgc   1560
 tgggagaccc ccaccttgga caggatgagg gtggctccat cccggacatt gtagtgcata   1620
 agggtgttga cgcgcttcca ccggccctcc cgctgtgacg tcaggtccag gtccgacagg   1680
 atctgcgctg tggagcccgg acgccactcc aggaccacgc tgtctggcct gggccagcag   1740
 gagcagggct gcccacggta cacctggtca atgatcttct ccttgacctg ggagatggtg   1800
 tcacagttga ggaccttcac cgggatggcg tccactccct cgtcctgcac gatcacgctc   1860
 accgtcaggg gtgcgtactc cacatcatcc cccagcagcc ccgtgtcgtt gagagtgtac   1920
 ttggccttct tctgtaccgc atccaccggg cccttttcca cctgatgttt gatggccttg   1980
 aagagcttgt acaggggctc cccggcactg tccttgaggt actggtacag gcagatggac   2040
 atccagttgg acagcatcct ctccaccaca gtctcagacc tgcgcagcat cagcttgggg   2100
 ttcttggcca ccacgtactg ctccaggagc tccaggaaga gcgtgtgcat gatgtccgtg   2160
 tagtactcca gtttcccgtg cagcgccacc gtcagcaggg acgcgaagta gaccttggcg   2220
 cgggccgaga actccggctg gttctcccag ggtgtggatg aaattgatga ggaaagactt   2280
 gctgttcagc aggttggaga actggtagag ggcctgctcc accaccggcc gccgcggctc   2340
 ggggatgtcc agcttgccgg tgatcatcac gtccttgtcg ccgtccttgg agggcaggaa   2400
 gaagacgcgg tcggtgtagg tcttgtagtc cagcacgggg atgccggcct cgtgcacgtc   2460
 gttggtctgg tcctccatct cgatcatcag gtctgtgaat tccttcttgc agcggtcccg   2520
 cacgctctcc tccaggccct ccagctggga cttgatcttc tcatactctc gttcggcctg   2580
 ctggctcttc ctccagtagc agtagacaga caccgcgatg acgaccacca tgggcacgat   2640
 gaccagcggc aagatgaggc tgagcggcac gtcgctcacc cgtgtgtcgt actccacgcg   2700
 gcccagcacc cactcgcgag agccgaactt cacaatgaac tcgggcaggt tgtgtgtggt   2760
 gtctcgtttc tgccgccgct tgggcggggg ctgcacctcc gggggctcac agtacaggtc   2820
 ggtctccgtc agcgtcttca tggtgcagcg ctcggcaccc acgaaggcct cggcctcctg   2880
 cagcgtcatc gccttgttca gattggtgcc ccgggcgcgg atgagcttgt tgacctgctt   2940
 cttgacgcca cctgtgaagt tctcaaaggt ggggtcaggc acgtactcga aggccccggc   3000
 ctctgttctg agcagggcac ggtgcccgtc catctcgatc agcaccgtga ggttgtaggc   3060
 ctctggctcc tcaggcacag ccggggacag gaagacgacc ttggtgtcat tgtggaacac   3120
 gtagtctgta cccaccaccg tcatgggctg cagggattca gcctcccgcg gcggctgcca   3180
 ggactgcagg ggctccgcga tgaccaccat ggcaaacctc tggatcaggc tgaagccctg   3240
 acccgtgacg ttgatgctgc ggccaccact ggcaaagctt cgtagcggct cgaaggctcg   3300
 cagtacgggg ttttcgcggt aggtgaagaa gatgccgggg ttgggcacgg gggacccccc   3360
 gtaggagacc tccagaagca tctggccccg tgtcgcctgg gggccagtga cacactggag   3420
 ctgcgcccca aacttcgtca ctttacacgg gacgccgttg agggtcaccc gcacgtcctc   3480
 ctgggagccc gtgtccaggt gggtgccgtg gatggtcagt gtggtgccgc ccgcctgcgg   3540
 tccctgctgc ggctccacac tgagaggctt gggctgttgg aaggtgaact ggacattggg   3600
 aggcgaacgg cccagtttcc cgaagacgtc cacctcgaca ccccccgtga aaggcgtctc   3660
 cgcagcctcg atcacacaca cgatccgggt ggacacggag taacgttccg gctgaaagga   3720
 gcagttccgg ccggccacag agatcctctg gatgtcccct gcttggacgc ccaaattgga   3780
 ccccaggatg gtgatgcgga tgcccccacc cagggggccc gtctcaggct ggatcctggt   3840
 gatgacgggc ggcgggcact cggaggtggt gttgcacagg gcctcataca cgcacctgct   3900
 ctggcccccg caccacgcac acctgtagtc ggggttagcg gcccggcaca ggctgcagtc   3960
 gctgcggcca aaggagcagt cgtagagggt cacatggagc ttgctgtcga tattcttgcc   4020
 gtaagacttg acgtaaaggt gcaggggcag cgtctcgttg gcatcgtggg acagctttgg   4080
 ggtccgaaag gcgaaggtcc cagattcctg catggtcacc ggctccatga acttgagcaa   4140
 gtcactgccc acgtgcaggg aggaaccctt cacggtgtcc aggttcttgc cctggaagtt   4200
 cacatctgtc tcgtggttca tggggatcac cagggggctg ggtcccagga actggggaca   4260
 gctgtcctcc atgtgggcac ggacgatgcc gtcctcaggg ttgggcgaag cctcccggca   4320
 ctcgtggtag cgcaggtccc actggcaggt ccagcggttg ctcacgcagg agatgcacgg   4380
 caggttctcc tccaggctca tggcctggcg gcagtcgtag aaggggtact ggtaggacgt   4440
 gaggaagatg ttgcctcgtc taaggaggag ctggatggtc acggccacgt ggtcctggcc   4500
 tggcggtgtg acggggatgc tgcttgggga gttgcagatg acggcctcgc cctccacgcg   4560
 ggcggggtgt ggcggcgact ccccaaaaag gcacagcaac tcgtcctcct cgctcagggc   4620
 agggaggggg ctgacggtca gctgcacctc cccctgggcc cgccggctca tgttctgtgg   4680
 ctgggcgctg gtgacggcca cgcaggactt gcttcggctc cacagccagt ggctggcctc   4740
 ctcggcccgc ggacactcgg ccttccgggt gcatcgtccc tcgacgacgc accagccgca   4800
 gtaggggtcc tgggagtcgc ggcactgggt gcaggtcggg tagctcaggc actcctgcac   4860
 cggcagccgg aacaccttgt cctgggtcat ggcgtacagg ctgcccaggt ctccagacag   4920
 taccaggtcg cgcttgactc tcttgtttat ctccacaagg atagagtcgt actctgagga   4980
 ggtgccatct ggggtgaggt acaccttgag gatccggcca tcagaggtgc ccagaaaagc   5040
 aacagtgtgg ttgttctcgg cggcgaccgt cacggccgtg aggttcaggc ctccacgctg   5100
 cagcacggct gtgcctctga gcccgtcgcg gctgcccagc gggtagggca ggtgctccga   5160
 gccacatggg aagctcttgc tggagcccgg cgcgtggccg ccgcactgga tatcgccgtg   5220
 gaagggcttg tagaagatgt cacgggcctc ccgggtgcct gtgtaacagg cgttgcggtt   5280
 ggcctccatc ttggcgtgca cctcgtccag cgggaacagg cagaggcccg caccgggccc   5340
 cccactgctc cggctgtctc tgctgaagac agcatatagc accctgccag agccaggcgc   5400
 agccacggag gcggccaggc aggtgccaaa ggcagcggcg tggatgtcgg ggtcccggca   5460
 ctgcaggtcc atctccaggt aggagtagta gttggggtct tctctgcaca tgcgtgccag   5520
 cagcgtgcgg ttccgggccg ggtgcttgtc ctgctggttg aagacaaaga agacgtaggg   5580
 gccgtcctcg aaggccgcca cgaactgctg tgtgttggtg gacaggtagc cggccttgta   5640
 ggtggcgtgg tccgtgtagg cttcaaaggc ctccctgctg tcagtccggt ccaacagccg   5700
 agtgctcacg atgatgccgt tgtcgtgtgg cccattgcct ttgcccacaa acagcacgcg   5760
 gtcaccacca ggacccgtgg agctcaccag ccccactgtg gccacgccct catcattgct   5820
 ggccacgaaa gacttctccc cgctgccgtc ctcgtagaac aggcggaggg agatgttgct   5880
 cagggcgcgc agagcgcagg atgcccttaa gaagctgccc gcactccacc aggcgtttcc   5940
 tgggagggtc gaccagcagc agctggttga cattgtcagt catctcagcc tcatggcact   6000
 ggctggcctc gatgggcggc gtgcacttct tgttgtccag gaccgggccc gtggccacct   6060
 gctgctccag ctgcagcttc gcatccagct ggtagagggc attcaccgcc cccaggtaca   6120
 ccacgcctga ggcctcatcc acagccaggt ggttcagctc tttctcgctg cggaagaagt   6180
 ccagcttgcg gggcctcagg ctggcacctg cgcccagcag gcccagcagg gtcagggccc   6240
 agagctgcag tgccattgcc ccctgcaccc gaggctccag tggtccagct cagtttctgc   6300
 tccaggccag catcgagatt ctcacgaaa                                     6329



      <210> 1704
      <211> 580
      <212> DNA
      <213> Homo sapiens


      <400> 1704
 agcatacaaa tgaaagtaaa ttaccgagtc ttagctgttc ctatcctagc aggatttata     60
 tttgacagca gaacacgagc tacagacttg caaaacctga agagcctcat caaacatcta    120
 aattgggatg gctttactgt gcctatttaa aaaaaaaaat gagagacttg ggcaatatga    180
 taactacttt gaattgtatt aagagagtct ccaaaacaga agcactgtag atttattcta    240
 cttcttcatt ctcttttcct ttcccttact ttttaggtta ctcagagagg gcaatgcttt    300
 actatgaact ggaagacggg ctgtacacca ctggtccata tttctttgcc aagatcctcg    360
 gcgagcttcc ggagcactgt gcctacatca tcatctacgg gatgcccacc tactggctgg    420
 ccaacctgag gccaggcctc cagcccttcc tgctgcactt cctgctggag tggctggcgg    480
 tcttctgttg caagattatg gtcctggccg ccgcgggcct gctccccacc ttacacatgg    540
 cctccttctt cagcaatgcc ctctacaact gcttctacct                          580



      <210> 1705
      <211> 3637
      <212> DNA
      <213> Homo sapiens


      <400> 1705
 agcggccgcc gcgcgccagc gggaggcgct ccctctgccc acctccgccc cctgcggacc     60
 gagacccgga gatgtcgagt tgtggagttc ggctcggccc ggcgacgggc tagctgcccg    120
 ggaacccccg cgggtggaca catgcatgcc ggagctccgg gaggggccgc gccgccaccg    180
 tctgaactag gatgtcccga catgaaggtg tcagctgtga tgcatgttta aaaggaaatt    240
 ttcgaggtcg cagatataag tgtttaattt gctacgatta cgatctttgt gcatcttgtt    300
 atgaaagtgg tgcaacaaca acaaggcata caactgacca cccaatgcag tgcatattaa    360
 caagggtaga ttttgattta tactatggtg gggaagcttt ctctgtagag cagccacagt    420
 cttttacttg tccctattgt ggaaaaatgg gctatacgga gacatctctt caagaacatg    480
 ttacttctga acatgcagaa acatcaacag aagtgatttg tccaatatgt gcagcgttac    540
 ctggaggcga tcctaatcat gtcacggatg actttgcagc tcatcttaca cttgaacaca    600
 gagcccctag agatttagat gaatcgagtg gtgttcgaca tgtacgtaga atgtttcacc    660
 ctggccgggg attaggaggt cctcgtgctc gtagatcaaa catgcacttt actagcagtt    720
 ctactggtgg actttcttct tctcagagtt catattctcc aagcaatagg gaagccatgg    780
 atcctatagc tgagctttta tctcagttat caggagtgag acgttctgca ggaggacagc    840
 ttaattcctc tggcccttcc gcttctcagt tacaacaact gcagatgcag ctgcagctag    900
 aacggcagca tgcccaggca gcacggcaac aactggagac cgcacgcaac gcaacccggc    960
 gtactaacac aagcagtgtc accactacaa tcacacaatc cacagcaaca accaacatag   1020
 ctaatacaga aagcagtcag cagactctac agaattccca gtttctttta acaaggttga   1080
 atgatcctaa aatgtctgaa acggagcgcc agtccatgga aagcgagcgt gcagaccgca   1140
 gcctgtttgt ccaagagctc cttctgtcca ctttagtgcg tgaagagagc tcatcctcag   1200
 atgaggatga tcggggggag atggcagatt ttggtgctat gggctgtgta gatattatgc   1260
 ctttagatgt tgctttagaa aacctaaatt taaaagagag taataaagga aatgagcctc   1320
 caccacctcc tctttgatga catcccaatt cgcagacaat gtcctctgtg ctgtatttgc   1380
 caatgaaagt ggacaacaac tatcttgggt ttgtttggtg attgtaattt caggtctgtc   1440
 actcttgtta cattgtgtac attcaaaagg aagagagaaa atatatatga taatcatttc   1500
 cacttaacta atttttactt ctagcaggta aatgtaggta gcagtgcagg ggtgatctct   1560
 gcttcctgta ccttgacatg caaaaggctc tcctaatact ccacattcaa actgaagagg   1620
 aaaattgaaa tctctaatga agctgctgtg tgtatttatg aatattaatg aataaaaact   1680
 gcttggatgg tttaccttaa ctactgcatg aggttttttg cagcgtgcat gagttttagt   1740
 gaccttgtta tttaagaagt taaatacaag gagtaaaact taaaaaaaaa atacaaagcc   1800
 caaagctttc ccaaacatta ttcaatggtt acacgacgaa gtaggctttt gaataatgtc   1860
 tgcctgaatc acctttcttt gtgtgcctcc tacgcacaaa gccagctctg cagtgggaat   1920
 ctgggggatt atagccgggt gtggcactcc gccctgtgtg actgtcctgt cgccctgtta   1980
 gtcatcttgc ctgtgtggag ctcagcctgt ctctttaact catctgtaga agacacacca   2040
 gtaaagctac tgttggaatc tgctgcaggg gcctttgtgt gccctaaaaa caaatcctgt   2100
 tcatgtttgt ttaaagtttt tactttttgt ggttgtttaa aattttttca attgttaaat   2160
 atgttttatt caggtgtaga tgaatttcat ttattgactg ttcaacagag ttaacctgaa   2220
 ttatgttgtc tttgttttta aaaatctcac attctcaatc atattttgca ttatttatgt   2280
 atttgctttg tagtttgctg agacagatca gtatcagggg agctttgagg atttgccttc   2340
 ccagatttgt cagtatatta caaccaaatt cttaatgcta attttagcac cttttattta   2400
 ttgggttttt tctggcataa aaagtaaagc cttttaattg aatcatgcca cctatatgcc   2460
 tatattatta atcctatgtg taaaaaaaat gtacagcttt ttttgggttt gttttggggt   2520
 ttggaagggc cgggttattt tttatttcct gtttcagttt ttgtgcatag actttcacaa   2580
 tagctccaag gcagggacag cgggtttggg ggttgggagg gcagtttttg gaatgtaaat   2640
 ttaggacttt taaaaaggtg cgcacagctt ctgataaatt tataactaga cttaacctaa   2700
 tcatgtctcg ttccagttct cttttctctg agcccttttc aaagtctcct ctctttctcc   2760
 tgtcatcctt ttcctttcct gtccgtgtat ctccgtttct tcaacatgac aagcatacag   2820
 acttgaacac ccctccggtg ttcttccgag aactgtgaag tccatgttca tccaaatgta   2880
 accaaaaaag aagtcaccct acatgtctga aaaactgttg cttctcctct gaaacttcaa   2940
 actccaacga tttccaaata caatagcttt gttttcttta gttctgtaat ggataatgtt   3000
 taaaggaaaa ctttacacca ggcttctggt tacactagaa gtcaagccca ttagggattt   3060
 tcattttttt tcatttggtt gttgagaagt ttcaaaaatc agttttcaag ctgtggtctt   3120
 tcaaacacat ctgcacataa gtcacacatt tcaataaagc attttcaaga ctgttgacca   3180
 cttgaatttc tttggtgtta gtggattaac ctaaccatta ctctgagatt ttatatctct   3240
 aatccagtat tttttttctt tttatgctaa acatgggaga tcctggtttt gtgtgaatgc   3300
 attattttgg atgtgagaaa taaatgccaa ttatatgtac tttccctttt ctgcacaaat   3360
 tctgggaaaa tgtaaaagcc ttcatttttt aacatggttt tagggaacaa ctgtaagtcc   3420
 attcagagca gtttaattta gatgatcact tttaacactg cagaagacct aaggagtcat   3480
 aagattccat ctcatgtaga atactgtata ttaattattt tttaccagat attttacaaa   3540
 tacctcacct catcctgtat gtaatcaata atgtattatt ttagggtaga acgacacaga   3600
 atatcaatat aaaaatatat tcaagccctt gaaaaaa                            3637



      <210> 1706
      <211> 397
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(397)
      <223> n = a,t,c or g


      <400> 1706
 acttcgcatg cccccgtacg taaacttgat tcctttaaac gggccgcccc nnnnnnnnnn     60
 nnnccaaagt agatcctnta ttcaaaatct gtgggggttt tttgactgtt tttgctgacc    120
 tgtgacctct cactgaggac ggcagtccag gaccaccccc agaggggttc aaagacctcc    180
 gaaaccagag accaccccca catacaggtc catggagagg gcctggacca tctggacccc    240
 cacggtcagg ccaagtccca gataatagca ccagatgttt cctgtccgac ttttggtctc    300
 cccaaggcga ccagaggccg agctgcccct acacaggcgc aaggccgagg cagggcgcag    360
 cacagcatct caggtgtcca tctcgccggc ggcgggc                             397



      <210> 1707
      <211> 458
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(458)
      <223> n = a,t,c or g


      <400> 1707
 cgcgggcgtt cgatgtgaga aggaaaaaga gcctcagacc ctgctgccca agggacttcc     60
 atgctggctg tctgactgtg agtggcccca gcaccgtgat gggcgccgtg ggggaatccc    120
 tgagtgttca gtgtcggtat gaagagaaat acaagacgtt taacaaatac tggtgcagac    180
 aaccatgctt gccaatttgg catgaaatgg tggagaccgg agggtctgag ggagtggtga    240
 ggagtgacca agtgatcatc acggaccatc ctggagacct caccttcacc gtgaccttgg    300
 agaacctcac ggcagacgat gcaggaaaat accgatgtgg gattgcaaca atactgcagg    360
 aagatggcct gtctggtttc ctgcccgatc ccttcttcca ggttcaagtg ctggtctcat    420
 cggcctccag tactgagaac tctgtgaaga cacctgcn                            458



      <210> 1708
      <211> 1549
      <212> DNA
      <213> Homo sapiens


      <400> 1708
 aattcccggg tcgacgattt cgtggccgtc atggcgcccc gaaccctcgt cctgctactc     60
 tcgggggctc tggccctgac ccagacctgg gcgggctctc actccatgag gtatttcttc    120
 acatccgtgt cccggcccgg ccgcggggag ccccgcttca tcgcagtggg ctacgtggac    180
 gacacgcagt tcgtgcggtt cgacagcgac gccgcgagcc agaggatgga gccgcgggcg    240
 ccgtggatag agcaggaggg tccggagtat tgggacgggg agacacggaa agtgaaggcc    300
 cactcacaga ctcaccgagt ggacctgggg accctgcgcg gctactacaa ccagagcgag    360
 gccggttctc acaccgtcca gaggatgtat ggctgcgacg tggggtcgga ctggcgcttc    420
 ctccgcgggt accaccagta cgcctacgac ggcaaggatt acatcgccct gaaagaggac    480
 ctgcgctctt ggaccgcggc ggacatggca gctcagacca ccaagcacaa gtgggaggcg    540
 gcccatgtgg cggagcagtt gagagcctac ctggagggca cgtgcgtgga gtggctccgc    600
 agatacctgg agaacgggaa ggagacgctg cagcgcacgg acgcccccaa aacgcatatg    660
 acccaccacc ccatctctga ccatgaagcc accctgaggt gctgggccct gagcttctac    720
 cctgcggaga tcacactgac ctggcagcgg gatggggagg accagaccca ggacacggag    780
 ctcgtggaga ccaggcctgc aggggatgga accttccaga agtgggcggc tgtggtggtg    840
 ccttctggac aggagcagag atacacctgc catgtgcagc atgagggttt gcccaagccc    900
 ctcaccctga gatgggagcc gtcttcccag cccaccatcc ccatcgtggg catcattgct    960
 ggcctggttc tctttggagc tgtgatcact ggagctgtgg tcgctgctgt gatgtggagg   1020
 aggaagagct cagatagaaa aggagggagt tactctcagg ctgcaagcag tgacagtgcc   1080
 cagggctctg atgtgtctct cacagcttgt aaagtgtgag acagctgcct tgtgtgggac   1140
 tgagaggcaa gagttgttcc tgcccttccc tttgtgactt gaagaaccct gactttgttt   1200
 ctgcaaaggc acctgcatgt gtctgtgttc gtgtaggcat aatgtgagga ggtggggaga   1260
 ccaccccacc cccatgtcca ccatgaccct cttcccacgc tgacctgtgc tccctcccca   1320
 atcatctttc ctgttccaga gaggtggggc tgaggtgtct ccatctctgt ctcaacttca   1380
 tggtgcactg agctgtaact tcttccttcc ctattaaaat tagaacctta gtataaattt   1440
 actttctcaa attcttgcca tgagaggttg atgagttaat taaaggagaa gattcctaaa   1500
 atttgagaga caaaataaat ggaagacatg agaaccttcc aaaaaaaaa               1549



      <210> 1709
      <211> 697
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(697)
      <223> n = a,t,c or g


      <400> 1709
 cggacgcgtg ggtcgcccac gcgtccggtg agctgccccc acaaaccacc aagaccctgg     60
 ctcgcttcat tcctgaagtg gctgtagctt atcccaagtc aaagcccttg acgacccaga    120
 tcaagataaa gaagcctccc aaggtcacta tgaagacagg caagagcctg ctgcacctcc    180
 acagcaccct ggagatgttc gcagctcggt ggcggagcaa ggctccaatg tccctctttc    240
 tcctagaagt gcacttcaat ctgaaggtcc agtactcagt gcatgagaac cagctgcaga    300
 tggccacttc tttggacagg agagggaatt aactggcttc atcaccagct atctcgaaga    360
 agcctacatc ccagttgtca atgatgtgct tcaagtgggg ctcccactcc cggactttct    420
 ggccatgaat tacaacctgg ctgagctgga catagtagag aatgccctga tgctggactt    480
 gaagctgggc tgaccatggc aggactcccc tgccagctgc ctgcttacca ccaaccacct    540
 gcaccccatg gaggagaccc cctgattgga gccaggtggg cctggccccc taccactggt    600
 ggctgcctcc tttgacaagg agtgaatggg tcangcctgg gctggagcct tgccaataaa    660
 caggagaaag gctcttataa atatctgaaa aaaaaaa                             697



      <210> 1710
      <211> 697
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(697)
      <223> n = a,t,c or g


      <400> 1710
 cggacgcgtg ggtcgcccac gcgtccggtg agctgccccc acaaaccacc aagaccctgg     60
 ctcgcttcat tcctgaagtg gctgtagctt atcccaagtc aaagcccttg acgacccaga    120
 tcaagataaa gaagcctccc aaggtcacta tgaagacagg caagagcctg ctgcacctcc    180
 acagcaccct ggagatgttc gcagctcggt ggcggagcaa ggctccaatg tccctctttc    240
 tcctagaagt gcacttcaat ctgaaggtcc agtactcagt gcatgagaac cagctgcaga    300
 tggccacttc tttggacagg agagggaatt aactggcttc atcaccagct atctcgaaga    360
 agcctacatc ccagttgtca atgatgtgct tcaagtgggg ctcccactcc cggactttct    420
 ggccatgaat tacaacctgg ctgagctgga catagtagag aatgccctga tgctggactt    480
 gaagctgggc tgaccatggc aggactcccc tgccagctgc ctgcttacca ccaaccacct    540
 gcaccccatg gaggagaccc cctgattgga gccaggtggg cctggccccc taccactggt    600
 ggctgcctcc tttgacaagg agtgaatggg tcangcctgg gctggagcct tgccaataaa    660
 caggagaaag gctcttataa atatctgaaa aaaaaaa                             697



      <210> 1711
      <211> 697
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(697)
      <223> n = a,t,c or g


      <400> 1711
 cggacgcgtg ggtcgcccac gcgtccggtg agctgccccc acaaaccacc aagaccctgg     60
 ctcgcttcat tcctgaagtg gctgtagctt atcccaagtc aaagcccttg acgacccaga    120
 tcaagataaa gaagcctccc aaggtcacta tgaagacagg caagagcctg ctgcacctcc    180
 acagcaccct ggagatgttc gcagctcggt ggcggagcaa ggctccaatg tccctctttc    240
 tcctagaagt gcacttcaat ctgaaggtcc agtactcagt gcatgagaac cagctgcaga    300
 tggccacttc tttggacagg agagggaatt aactggcttc atcaccagct atctcgaaga    360
 agcctacatc ccagttgtca atgatgtgct tcaagtgggg ctcccactcc cggactttct    420
 ggccatgaat tacaacctgg ctgagctgga catagtagag aatgccctga tgctggactt    480
 gaagctgggc tgaccatggc aggactcccc tgccagctgc ctgcttacca ccaaccacct    540
 gcaccccatg gaggagaccc cctgattgga gccaggtggg cctggccccc taccactggt    600
 ggctgcctcc tttgacaagg agtgaatggg tcangcctgg gctggagcct tgccaataaa    660
 caggagaaag gctcttataa atatctgaaa aaaaaaa                             697



      <210> 1712
      <211> 697
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(697)
      <223> n = a,t,c or g


      <400> 1712
 cggacgcgtg ggtcgcccac gcgtccggtg agctgccccc acaaaccacc aagaccctgg     60
 ctcgcttcat tcctgaagtg gctgtagctt atcccaagtc aaagcccttg acgacccaga    120
 tcaagataaa gaagcctccc aaggtcacta tgaagacagg caagagcctg ctgcacctcc    180
 acagcaccct ggagatgttc gcagctcggt ggcggagcaa ggctccaatg tccctctttc    240
 tcctagaagt gcacttcaat ctgaaggtcc agtactcagt gcatgagaac cagctgcaga    300
 tggccacttc tttggacagg agagggaatt aactggcttc atcaccagct atctcgaaga    360
 agcctacatc ccagttgtca atgatgtgct tcaagtgggg ctcccactcc cggactttct    420
 ggccatgaat tacaacctgg ctgagctgga catagtagag aatgccctga tgctggactt    480
 gaagctgggc tgaccatggc aggactcccc tgccagctgc ctgcttacca ccaaccacct    540
 gcaccccatg gaggagaccc cctgattgga gccaggtggg cctggccccc taccactggt    600
 ggctgcctcc tttgacaagg agtgaatggg tcangcctgg gctggagcct tgccaataaa    660
 caggagaaag gctcttataa atatctgaaa aaaaaaa                             697



      <210> 1713
      <211> 1232
      <212> DNA
      <213> Homo sapiens


      <400> 1713
 ggggagggtg acgcactagc tctccagttc gcccgttcct ggcctgaccc ccaccaaggc     60
 ccataccgct gtaggctcct cgggctgccc ctcggttgac aatggtctcc aggatggtct    120
 ctaccatgct atctggccta ctgttttggc tggcatctgg atggactcca gcatttgctt    180
 acagcccccg gacccctgac cgggtctcag aagcagatat ccagaggctg cttcatggtg    240
 ttatggagca attgggcatt gccaggcccc gagtggaata tccagctcac caggccatga    300
 atcttgtggg cccccagagc attgaaggtg gagctcatga aggacttcag catttgggtc    360
 cttttggcaa catccccaac atcgtggcag agttgactgg agacaacatt cctaaggact    420
 ttagtgagga tcaggggtac ccagaccctc caaatccctg tcctgttgga aaaacagcag    480
 atgatggatg tctagaaaac acccctgaca ctgcagagtt cagtcgagag ttccagttgc    540
 accagcatct ctttgatccg gaacatgact atccaggctt gggcaagtgg aacaagaaac    600
 tcctttacgg gaagatgaag ggaggagaga gacgaaagcg gaggagtgtc aatccatatc    660
 tacaaggaca gagactggat aatgttgttg caaagaagtc tgtcccccat ttttcagatg    720
 aggataagga tccagagtaa agagaagatg ctagacgaaa acccacatta cctgttaggc    780
 ctcagcatgg cttatgtgca cgtgtaaatg gagtccctgt gaatgacagc atgtttctta    840
 catagataat tatggataca aagcagctgt atgtagatag tgtattgtct tcacaccgat    900
 gattctgctt tttgctaaat tagaataaga gcttttttgt ttcttgggtt tttaaaatgt    960
 gaatctgcaa tgatcataaa aattaaaatg tgaatgtcaa caataaaaag caagactatg   1020
 aaaggctcag atttcttgca gtttaaaatg gtgtctgagg ttgtactatt ttggccaagt   1080
 ctgtagaaag ctgtcatttg attttgatta tgtagttcat ccagcccttg ggcattgtta   1140
 tacaccagta aagaaggctg tactcaagag gaggagctga cacatttcac ttggctgcgt   1200
 cttaataaac atgaatgcaa gcaaaaaaaa aa                                 1232



      <210> 1714
      <211> 606
      <212> DNA
      <213> Homo sapiens


      <400> 1714
 ccccagcatt agaaaacatg gcacccaccc gtttccaccc acctagagca gcccctcggg     60
 ctcctgtagg ccactgtata gcgcatagcc aatgtcgtca atctcctcct cacgcaagct    120
 gctgaagagg ttcacgctgg ggttgaagtg gcagggcagg ctggcctgct ccaggctgcc    180
 gatgagcagc tccagggctt gcaggaagcg ctcacccaag gcctcctccg tccaatccac    240
 gttgtcctcc cccagacgca ggaccacctg ggtcaggtga ccccggccta gctgccccag    300
 agccgagcaa ccacggcaga cagcacacag cagcagcagc agccgccggc gagtcccagc    360
 gtcatggtcg tccagggctc gcagcctagc agcctccact ggatacaggt cctgcagcca    420
 gaggttcccc gccagcccct ccaggggcca ggccaagagg aggcggtcgt cagcatcgac    480
 cccagggact gccacaagca cagccacagt gagctccagg cgttcgtgct gcacctcgag    540
 cagcagctcc tccgaggcca tgctgggccg gatcaggcac ccgagaaggc tgcccggacg    600
 cgtggg                                                               606



      <210> 1715
      <211> 1202
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1202)
      <223> n = a,t,c or g


      <400> 1715
 cctttgagtc acctaggccg cctggggctg agaagaccta accgaggggc cagatggctt     60
 cgaccggctt agaactgctg ggcatgaccc tggctgtgct gggctggctg gggaccctgg    120
 tgtcctgcgc cctgcccctg tggaaggtga ccgccttcat cggcaacagc atcgtggtgg    180
 cccaggtggt gtgggagggc ctgtggatgt cctgcgtggt gcaaagcacg ggccagatgc    240
 agtgcaaggt gtacgactca ctgctggctc tgccgcagga cctgcaggcc gcacgtgccc    300
 tctgtgtcat tgccctcctg ctggccctgc ttggcctcct ggtggccatc acaggtgccc    360
 agtgtaccac gtgtgtggag gacgaaggtg ccaaggcccg tatcgtgctc accgcggggg    420
 tcatcctcct cctcgccggc atcctggtgc tcatccctgt gtgctggacg gcgcacgcca    480
 tcatccagga cttctacaac cccctggtgg ctgaggccct caagcgggag ctgggggcct    540
 ccctctacct gggctgggcg gcggctgcac tgcttatgct gggcgggggg ctcctctgct    600
 gcacgtgccc cccgccccag gtcgagcggc cccgcggacc tcggctgggc tactccatcc    660
 cctcccgctc gggtgcatct ggactggaca agagggacta cgtgtgaggc ggaggtttcc    720
 cctgggagcc cactgctccc cactgcccgg ccctttcgac cttggcctga tgaccagatg    780
 ccctgctcca tcacaacctc cttccccagg aaaacccact ttccaaaagc ccaagctaca    840
 cctggctgca gggctgggtc agctggcctg gctgagctct tctcagtggg gtcccctttg    900
 atgttctccc ccaagttggg cagcctagag gtgttgggaa ccctggcctg cccccacctc    960
 cccagtaatt gtttccttcc gttgcacagg acactggctg gccttccttc tcttctgagc   1020
 cctcccctgc cccaggaacc ctggcctcac caaaacagca gcagctcgtt ggctccaaaa   1080
 ccagggagca gaccatgccc tcccaaccct ggagttgtca gggagggcct gcccatcacc   1140
 tccctctccc caacatcccc accctcgagt tggaaataaa gagcatttgt anaaaaaaaa   1200
 aa                                                                  1202



      <210> 1716
      <211> 781
      <212> DNA
      <213> Homo sapiens


      <400> 1716
 tttcgtagcg aacatgctgt gtgggctcag ccgggagacc cctggagagg cggacgatgg     60
 gccctactcc aaaggaggca aggacgcagg aggggccgac gtttgcctgg cgtgccgcag    120
 acagagcatt ccagaggagt tccgagggat cactgtggtg gagctgatca agaaagaagg    180
 cagcacgctg ggcctgacta tctcaggtgg caccgacaag gatggaaagc ccagggtctc    240
 caacctgaga cctgggggac ttgcagccag gagtgatctg ctgaacattg gtgactatat    300
 tcggtctgtg aacgggatcc acctgaccag gctccgccac gatgagatca tcaccctgct    360
 caagaatgtg ggcgagcgcg tggtgctgga gctcctgaga ataaccccag gatcatttca    420
 aagacagtgg acgtctccct ctacaaggag ggcaatagct ttggctttgt ccttagaggt    480
 cagtgaaaga attgcccttg gtattggggc agcaagaaag aggctaatac taattccatg    540
 tgtgtgctgt ttggatttga atgtaattta tgtgtatctc agttctgact ttgaagaaca    600
 cagggccgtt aaggtaagta ttcagtggga aaatctgcca agcaatgaag taggcttggt    660
 tggggagagt gagaggagaa agttgtaccg gaaaatgatg gtgaaagctg ctaccgagac    720
 tgagaacaaa gtctggagct tcatagagat cagggaaaag gggaaataag gtgagtgtat    780
 t                                                                    781



      <210> 1717
      <211> 2244
      <212> DNA
      <213> Homo sapiens


      <400> 1717
 ccgactcggc ttgaggtacc gggtccacga tttcgtggat gcagagagct cagttttttt     60
 ttctaccatt taaactttaa atctctgtgg ttcggctcat aaagcaggct ttcaagaggg    120
 tgtcaaccgc cgagagaacc cagaggcagg gagtccgaga tggggggagg tcgtgtcgcg    180
 gcgtctgaaa ggggccactg gcactcaaaa agagtgaatg aaatgtgcag ctcagagtgt    240
 catttctgaa gggaggagtc tttctcttgg agaagagtcc tcaatgagcc tggccgaggc    300
 ccgggatctg tgtgaagtgg actaaggatt aagtaggatg tcaactgaga cagaacttca    360
 agtagctgtg aaaaccagcg ccaagaaaga ctccagaaag aaaggtcagg atcgcagtga    420
 agccactttg ataaagaggt ttaaaggtga aggggtccgg tacaaagcca aattgatcgg    480
 gattgatgaa gtttccgcag ctcggggaga caagttatgt caagattcca tgatgaaact    540
 caagggcgtt gttgctggcg ctcgttccaa aggagaacac aaacagaaaa tctttttaac    600
 catctccttt ggaggaatca aaatctttga tgagaagaca ggggcccttc agcatcatca    660
 tgctgttcat gaaatatcct acattgcaaa ggacattaca gatcaccggg cctttggata    720
 tgtttgtggg aaggaaggga atcacagatt tgtggccata aaaacagccc aggcggctga    780
 acctgttatt ctggacttga gagatctctt tcaactcatt tatgaattga agcaaagaga    840
 agaattagaa aaaaaggcac aaaaggataa gcagtgtgaa caagctgtgt accagacaat    900
 attggaagag gatgttgaag atcctgtgta ccagtacatt gtgtttgagg ctggacacga    960
 gccaatccgt gatcccgaaa cggaagaaaa catttatcag gttcccacca gccaaaagaa   1020
 ggaaggtgtt tatgatgtgc caaaaagtca acctgtaagt gctgtgaccc aattagaact   1080
 ttttggggac atgtccacac cccctgatat aacctctccc cccactcctg caactccagg   1140
 tgatgccttt atcccatctt catctcagac ccttccagcg agtgcagatg tgtttagttc   1200
 tgtacctttc ggcactgctg ctgtaccctc aggttacgtt gcaatgggcg ctgtcctccc   1260
 gtccttctgg ggtcagcagc ccctcgtcca acagcagatg gtcatgggtg cccagccacc   1320
 agtcgctcag gtgatgccgg gggctcagcc catcgcatgg ggccagccgg gtctctttcc   1380
 tgccactcag cagccctggc caactgtggc cgggcagttt ccgccagccg ccttcatgcc   1440
 cacacaaact gttatgcctt tgccagctgc catgttccaa ggtcccctca ccccccttgc   1500
 caccgtccca ggcacgagtg actccaccag gtcaagtcca cagaccgaca agcccaggca   1560
 gaaaatgggc aaagaaacgt ttaaggattt ccagatggcc cagcctccgc ccgtgccctc   1620
 ccgcaaaccc gaccagccct ccctcacctg tacctcagag gccttctcca gttacttcaa   1680
 caaagtcggg gtggcacagg atacagacga ctgtgatgac tttgacatct cccagttgaa   1740
 tttgacccct gtgacttcta ccacaccatc gaccaactca cctccaaccc cagcccctag   1800
 acagagctct ccatccaaat catcagcatc ccatgccagt gatcctacca cagatgacat   1860
 ctttgaagag ggctttgaaa gtcccagcaa aagcgaagag caagaagctc ctgatggatc   1920
 acaggcctca tccaacagtg atccatttgg tgagcccagt ggggagccca gtggtgataa   1980
 tataagtccg cagggccggt agctaagatt agcgcaggtc tgggagccag agcctctgta   2040
 cgcgcagatc aacagaccta agaaatagca tcgatgcgag ctcgtggtgg gtgctcaaga   2100
 ctggcatgga catcagcatc acgacaggct ctcttgtatt ctttcacctc ttcccacaag   2160
 aaattcatga ttgcccaatg gaactcgctc agaagaggga actaagcatt tttggcaacc   2220
 aatggcagaa ataaatggca gcac                                          2244



      <210> 1718
      <211> 428
      <212> DNA
      <213> Homo sapiens


      <400> 1718
 cttatttcct cagtggaaat ctactcacta tgatgtggta gttggcgtgt tgtcagctcg     60
 caataaccat gaacttcgaa acgtgataag aagcacctgg atgagacatt tgctacagca    120
 tcccacatta agtcaacgtt ttgaatcagg aaattgaagc gttcagtctg tccgaagaca    180
 cttcatcggg gctgcctgag gatcgagttg tcagcgtgag tttccgagtt ctctacccca    240
 tcgttattac cagtcttgga gtgttctacg atgccaatga tgtgggtttc cagaggaaca    300
 tcactgtcaa actttatcag gcagaacaag aggaggccct cttcattgct cgcttcagtc    360
 ctccaagctg tggtgtgcag gtgaacaagc tgtggtacaa gcccgtggaa caattcatct    420
 taccagag                                                             428



      <210> 1719
      <211> 3428
      <212> DNA
      <213> Homo sapiens


      <400> 1719
 ggagaaacgg agcccttgga agttgtaccc ttaggttccc ctgcggttct gggcccaggt     60
 ctgcagcctc cactctgggc ttgccggctg tgaggtgcgc tggttatagg actgtgtggg    120
 ggctgcatat caggtgatct cagctatcac cttctcccag cacctggctt ccagctcatg    180
 gggtgggact atcccactca cccctctgct ataggcactg cccatcttat gctgctggcc    240
 ctggcctcac ctggtcactt ccaccaacag gagctcccag ataacagtgg gttgctggac    300
 agatcaggct gggactctta aggggtgggg gacgtggggc cttcagtgct ttatccccta    360
 ggaaagggtg cacgttatcc caagggagcc cccaggaagt ggggagggag gggggaggag    420
 catgtctagg tgctgaccac ctggagcact tggccagcaa gtgggccgca tgctttggga    480
 gcaatgggtg acccagcagg aagcacaaaa gaccggccag tgtgccatca tcaagggctg    540
 ctgagcagct tgaagagcca ctgggtgggg agggcacacg gggaggtctc agctggggct    600
 gcccctggag gacagggcag ggaacttgag ggctgaggac agaaatctca catgactcca    660
 ggaaatagag gaagaggagg atgctgagcg agggattgtg agggagtggg ggtaggtcag    720
 agggggctga actgcaggaa gccaggggga gtcgtggacc actggagctg gccagcccca    780
 gggcattggg gacaaggcca ggtcagaggg agacagtgtg ggcctggtgg gtggaccctg    840
 gcagaggccc tcttgtcccc cacaaggcca ggccacactg tgattctgcc tgtacctgag    900
 catctgtcct gtgctcctag gccggagacc actgtgtgtc aggtggggcg gttggctgag    960
 tcccagagaa aaacactcct cactgggcac tcttgatgct tgcacacacc ctgtggttta   1020
 tttggtggtc agtaaggaac gtctttgctg ctaagtggaa gaaagctaat ggaacgtaat   1080
 caaaatagtg gtttaattga cgaattttac ttgcacctgt gccttcttca gatcctacct   1140
 gcctacttag tttacgtgaa ggccgactgc accatgcccc ccaaccccga cccccaccac   1200
 acacaacggg gccattgtca tgctaggtgc ttgctttccc cacctcagct ccggagatgt   1260
 gatggtcttt ggctctggag gtctcggcca gcctgtcctc catcctgttc tcgttctcgg   1320
 gcaccaccag cagccggtgc tgggttttgg ctccaagctt gtggtcgggc cggtggtcgg   1380
 gcctcaagcc tgtcttggtg tccagtttgc actcagcgcg gtacttgccc tccccctccc   1440
 tcttgaagga ggcagaagac gtggcttttg ggcttggggg gctgcagcca cgagtggctt   1500
 aggatctcat cgatgtggag ccgcttggct gacgtcgggc ctgcagcatg cggtagatga   1560
 ggtccttgca ctcgcaggtc aggttcttgg agcgcgggaa gtccacacgg tgctccttct   1620
 ggatacgcag catcttcctg atgtcggagt cgtcataggg catggagccg cagaccatga   1680
 tgtacaggat cacgcccagg ctccagatgt catacacctt gggctggtag gggatgctct   1740
 gcagcacctc gggggctgca tatgctgccg acccgcagaa ggtcttgctg aggatgatgc   1800
 gcccattgct gtcccgcagg cagcgcttgg agaagccaaa gtcagacagc ttgatgttga   1860
 agtccttgtc gaggagaagg ttctcgcact tgaggtcccg gtggacgatg tccaggtcgt   1920
 ggcagtactt gacggcggag gagagctgtc ggaacatctt gcgtgccacg tcctcatgca   1980
 gggctccctg gcacttgatg aactcgagga ggtcgccctg gacgccaagc tccatgatga   2040
 tgtagatccg tccgtcagag gtctcaaaga tctcgtaagt cttgatgatg gagccgtggt   2100
 tgacagttgc caggatgtcc atctcccgag gaaggaatct ctccacaaag tcagtagggg   2160
 ttttcttgcg ggcgatgatc ttgacagcca cattgaactt gaggcgctca gagtaggcag   2220
 atttgacttt tgcgtaggaa cccttgccaa gattgatgcc tacgatgtaa cccttcttcc   2280
 ttaggactgt ggcatcgtcc atggtgccag gagcgactgg cgccgctgcc gtctacatcc   2340
 ccccgtcatg tgggccagca ggcattgtcc tcatttacac taccggaggc gtctggctgg   2400
 gctgccctgg gctgggcttc gactcagggg tggaacactc agcattgtct ccgggtgact   2460
 tcagccaatg aactcataaa gccaaggagt gggggcgggg actgggctga gggagaacag   2520
 ggtctctgga accgtggaag ccaggctggt ctggcaggag cacccactcc ccgcccgctg   2580
 gaaggaagcc tgtccccagg acaggactct ggtggccctg ctgctgctgc attggtttcc   2640
 ctgtcacaag tcaagctgga ggggaggcgg cccacgtcca gcctgtttgc atcacctggc   2700
 tgtggggact gaccctgcat tggtctttgt cccactaggg tgggtttcct gcagcttctt   2760
 tggctatgaa gaaaagcacc cccagggctg tgtccttggt gtggtaggac agttgtccct   2820
 gacagtcacc cagacaggcc tgcatagcac cccagttaca cagacagatt tccacagcac   2880
 tgccttacca ttgagcacat agttaaatct agggaaatca gtgcccagac atcaaagcta   2940
 gaaatgaaac atggtcagca ggagccttgc atgggcttct cttttgctgg agcaagccaa   3000
 aataatagga acggttttac attcctagtg ccaggaccca tctcgggtcg acaaaatctg   3060
 aagacaagtt aagggaacag gcagctgttt gaatagatca attggatagt ctaaggcagc   3120
 tctctggacc aagctgtaaa ggagatacaa tcgaaataat cactccggta ccacagtaga   3180
 caggccttga aggcactggg ccccttttaa tcggacttag caagcatttt ttttgcctct   3240
 gaccttctcc ttggaacaaa attagttacc gagtagactt aggtgattgc tgtactgcat   3300
 gtaggcacat aaccccaacc tatataaaca gtaagaaaat tgtagcactt tgagttggtc   3360
 tgctggaatt atctccagcc ttctccctgt atccagttac actgactaaa ctcccttctc   3420
 tcctacac                                                            3428



      <210> 1720
      <211> 1389
      <212> DNA
      <213> Homo sapiens


      <400> 1720
 agccagtcgc tgcaaaccaa accgcgtgtg tccgctgggt ctctgggcat gcagtttgct     60
 cccactgcgg gaatggggtg ggggcaggcc gagcctgggc tctgggggct ttgctggggg    120
 agcttctggt cctgggggta cccacttgtg agggagtggg gggacagctg gaatagcgtt    180
 gctcagtgcg tcctttgggc gctgttgggg acaccctccc tcgctctccc acaccactgg    240
 caccaggccc cggacacccg ctctgctgca ggagaatggc tactcatcac acgctgtgga    300
 tgggactggc cctgctgggg gtgctgggcg acctgcaggc agcaccggag gcccaggtct    360
 ccgtgcagcc caacttccag caggacaagt tcctggggcg ctggttcagc gcgggcctcg    420
 cctccaactc gagctggctc cgggagaaga aggcggcgtt gtccatgtgc aagtctgtgg    480
 tggcccctgc cacggatggt ggcctcaacc tgacctccac cttcctcagg aaaaaccagt    540
 gtgagacccg aaccatgctg ctgcagcccg cggggtccct cggctcctac agctaccgga    600
 gtccccactg gggcagcacc tactccgtgt cagtggtgga gaccgactac gaccagtacg    660
 cgctgctgta cagccagggc agcaagggcc ctggcgagga cttccgcatg gccaccctct    720
 acagccgaac ccagaccccc agggctgagt taaaggagaa attcaccgcc ttctgcaagg    780
 cccagggctt cacagaggat accattgtct tcctgcccca aaccgataag tgcatgacgg    840
 aacaatagga ctccccaggg ctgaagctgg gatcccggcc agccaggtga cccccacgct    900
 ctggatgtct ctgctctgtt ccttccccga gcccctgccc cggctccccg ccaaagcacc    960
 cctgcccact cgggcttcat cctgcacaat aaactcggta tgccacacca ctggcaccag   1020
 gccccggaca cccattctcc tgcagcagga gaatggctac tcatcacacg ctgtggatgg   1080
 gactggccct gctgggggtg ctgggcgacc tgcaggcagc accggaggcc caggtctccg   1140
 tgcagcccaa cttccagcag gacaagttcc tggggcgctg gttcagcgcg ggcctcgcct   1200
 ccaactcgag ctggctccgg gagaagaagg cggcgttgtc catgtgcaag tctgtggtgg   1260
 cccctgccac ggatggtggc ctcaacctga cctccacctt cctcaggaaa aaccagtgtg   1320
 agacccgaac catgctgctg cagcccgcgg ggtccctcgg ctcctacagc taccggagtc   1380
 cccactggg                                                           1389



      <210> 1721
      <211> 394
      <212> DNA
      <213> Homo sapiens


      <400> 1721
 ggccatccac gtgcgttgcc tcctgtctcc cggccacacc gccggccaca tgagctactt     60
 cctgtgggag gacgattgcc cggacccacc cgccctgttc tcgggcgacg cgctgtcggt    120
 ggccggctgc ggctcgtgcc tggagggcag cgcccagcag atgtaccaga gcctggccga    180
 gctgggtacc ctgccccccg agacgaaggt gttctgcggc cacgagcaca cgcttagcaa    240
 cctggagttt gcccagaaag tggagccctg caacgaccac aagagggatg aggatgacgt    300
 gcccactgtg ccgtcgactc tgggcgagga gcgcctctac aaccccttcc tgcgggtggc    360
 agaggagccg gtgcgcaagt tcacgggcaa ggcg                                394



      <210> 1722
      <211> 1220
      <212> DNA
      <213> Homo sapiens


      <400> 1722
 gctggaggaa gtactcaaga gtgagctgag tggaaacttc gagaagacag cgttggccct     60
 tctggaccat cccagcgagt acgccgcccg gcagctgcag aaggctatga agggtctggg    120
 cacagatgag tccgtcctca ttgagttcct gtgcacgagg accaataagg aaatcatcgc    180
 cattaaagag gcctaccaaa ggctatttga taggagcctc gaatcaaatg tcaaaggtga    240
 tacaagtgga aacctaaaaa aaatcctggt gtctctgctg caggctaatc gcaatgaagg    300
 agatgacgtg gacaaagatc tagctggtca ggatgccaaa gatctgtatg atgcagggga    360
 aggccgctgg ggcactgatg agcttgcgtt caatgaagtc ctggccaaga ggagctacaa    420
 gcagttacga gccacctttc aagcctatca aattctcatt ggcaaagaca tagaagaagc    480
 cattgaagaa gaaacatcag gcgacttgca gaaggcctat ttaactctcg tgagatgtgc    540
 ccaggattgt gaggactatt ttgctgaacg tctgtacaag tcgatgaagg gtgcggggac    600
 cgatgaggag acgttgattc gcataatcgt gaccagggcc gaggtggacc ttcaggggat    660
 caaagcaaag ttccaagaga agtatcagaa gtctctctct gacatggttc gctcagatac    720
 ctccggggac ttccggaaac tgctagtagc cctcttgcac tgagccaagc cagggcaata    780
 ggaacacagg gtggaaccac ctttgtcaag agcacattcc aaatcaaact tgcaaatgag    840
 actcccgcac gaaaaccctt aagagtcccg gattactttc ttggcagctt aagtggcgca    900
 gccaggccaa gctgtgtaaa gttaagggca gtaacgttaa gatgcgtggg cagggcacct    960
 tgaactctgg cttagcaagc atctaggctg cctcttcact tttttttagg catggtaact   1020
 ggatgttttc taaacactaa tgaaatcagc agttgatgaa aaaactatgc atttgtaatg   1080
 gcacatttag aaggatatgc atcacacaag taaggtacag gaaagacaaa attaaacaat   1140
 ttattaattt tccttctgtg tgttcaattt gaaagcctca ttgttaatta aagttgtgga   1200
 ttatgcctct aaaaaaaaaa                                               1220



      <210> 1723
      <211> 2428
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2428)
      <223> n = a,t,c or g


      <400> 1723
 gtcagcacag ttctagggcg gggatatcat ctgtggccat gccctgggca cccctgggtc     60
 actccggctc ccaccagctc tgtgtaactt tctcctccct ccactgtttg accaggcgca    120
 acatgcatca gatgacggac gggctggata agccaggtca gatccgctgg ccactggcca    180
 tcacgctggc catcgcctgg atccttgtgt atttctgtat ctggaagggt gttggctgga    240
 ctggaaaggt ggtctacttt tcagccacat acccctacat catgctgatc atcctgttct    300
 tccgtggagt gacactgccc ggggccaagg agggcatcct cttctacatc acacccaact    360
 tccgcaagct gtctgactcc gaggtgtggc tggatgcggc aacccagatc ttcttctcat    420
 acgggctggg cctggggtcc ctgatcgctc tcgggagcta caactctttc cacaacaatg    480
 tctacaggga ctccatcatc gtctgctgca tcaattcgtg caccagcatg ttcgcaggat    540
 tcgtcatctt ctccatcgtg ggcttcatgg cccatgtcac caagaggtcc attgctgatg    600
 tggcggcctc aggccccggg ctggcgttcc tggcataccc agaggcggtg acccagctgc    660
 ctatctcccc actctgggcc atcctcttct tctccatgct gttgatgctg ggcattgaca    720
 gccagttctg cactgtggag ggcttcatca cagccctggt ggatgagtac cccaggctcc    780
 tccgcaaccg cagagagctc ttcattgctg ctgtctgcat catctcctac ctgatcggtc    840
 tctctaacat cactcagggg ggtatttatg tcttcaaact ctttgactac tactctgcca    900
 gtggcatgag cctgctgttc ctcgtgttct ttgaatgtgt ctctatttcc tggttttacg    960
 gtgtcaaccg attctatgac aatatccaag agatggttgg atccaggccc tgcatctggt   1020
 ggaaactctg ctggtctttc ttcacaccaa tcattgtggc gggcgtgttc attttcagtg   1080
 ctgtgcagat gacgccactc accatgggaa actatgtttt ccccaagtgg ggccagggtg   1140
 tgggctggct gatggctctg tcttccatgg tcctcatccc cgggtacatg gcctacatgt   1200
 tcctcacctt aaagggctcc ctgaagcagc gcatccaagt catggtccag cccagcgaag   1260
 acatcgttcg cccagagaat ggtcctgagc agccccaggc gggcagctcc accagcaagg   1320
 aggcctacat ctagggtggg ggccactcac cgacccgaca ctctcacccc ccgacctggc   1380
 tgagtgcgac caccacttga tgtctgagga taccttccat ctcaacctac ctcgagtggc   1440
 gagtccagac accatcacca cgcaggacag gggaggtggg aggacagtta gacccctggg   1500
 tgggccctgc cgtgggcaag gatacccggt ggcttctggc acctggcggg ctggtgacct   1560
 ttttaatcca ggccccatca gcatcccacg atcggccttg gtaaccgccg cggtagatca   1620
 tttttatccc gccagggagt gtgatgcagg aagaccacat gcgctcctgg cttttaaacc   1680
 tgttcctgac tgttctctta ctgccgaaac ccttgactgt tatctcggac tttgcaggag   1740
 ttcctttccc tccgaacgct gctccatgca caggaaaagg gcattttgtt acaatggggg   1800
 actttcccgg gaacgcttgc tcttaagtac cagaagccgg cggagctctg gctttcgtga   1860
 ttttggtttt ctccttccca aggcagctgg attgaaaaaa caaaacaaaa caaaaaaacc   1920
 caggggcgtc agtcgatatt ctcagggccg cttctcctgc agtctgtgga gcgtccttgt   1980
 ccccgccgcc ggaatgaatg agcattctgc agcccgatgt ccctgtcccc tcctcgccgg   2040
 gccattctga ttggacctgg cccagtgcaa tctgtccaga caagccctgc ttgctggaaa   2100
 actgccacaa gcacaattga tctcttttta tcgccattcc aggggcctca ggtcctactg   2160
 gggaaacttc ctataccgga gctccagttt ctcttaagct gcccaatttc acagagtaca   2220
 aaatagttgt aggggaaatc aaggtgaagg atctgtccga cagtcaagac ggatccacag   2280
 gaatctttcg gtctccttaa actaccaccc tcgctgccac ccaccccaag gtgnttgccg   2340
 cctcaccttc cttgaaattt ctcagcggga gtctcaacac aaccactaaa acccacccag   2400
 accgtgtatt gcggccgctc gagaggat                                      2428



      <210> 1724
      <211> 978
      <212> DNA
      <213> Homo sapiens


      <400> 1724
 tttcgtggcg actgtccgtg gtgctgagcg ccggcgagag cgggcgcgga gcggctgatc     60
 ggctccctcg aactggggag gtccagtggg gtcgcttagg gcccaaagcc cccacccggc    120
 tccaaaagct cccagggcct ccccaggcac cggtgctcgg cccttccttc ggtcagaaag    180
 tcgccccctg ggggcagttc gtcccaaagg gtttcctcga aagaatctga gagggcgcag    240
 tccttgaccg agggaatctc tctgtgtagc cttggaagcc gccagcccca gaagatgcct    300
 gccttcaata gattgtttcc cctggcttct ctcgtgctta tctactgggt cagtgtctgc    360
 ttccctgtgt gtgtggaagt gccctcggag acggaggccg tgcagggcaa ccccatgaag    420
 ctgcgctgca tctcctgcat gaagagagag gaggtggagg ccaccacggt ggtggaatgg    480
 ttctacaggc ccgagggcgg taaagatttc cttatttacg agtatcggaa tggccaccag    540
 gaggtggaga gcccctttca ggggcgcctg cagtggaatg gcagcaagga cctgcaggac    600
 gtgtccatca ctgtgctcaa cgtcactctg aacgactctg gcctctacac ctgcaatgtg    660
 tcccgggagt ttgagtttga ggcgcatcgg ccctttgtga agacgacgcg gctgatcccc    720
 ctaagagtca ccgaggaggc tggagaggac ttcacctctg tggtctcaga aatcatgatg    780
 tacatccttc tggtcttcct caccttgtgg ctgctcatcg agatgataca ttgcctacag    840
 aacggtgatc acagacgaac caggccccca acagaaaccg gatggctacc tttgcgattc    900
 catttgagaa cagggaaaat tcttcggtac ctgcgggggg aataatacag gccctctgct    960
 taccttgagg cccccccc                                                  978



      <210> 1725
      <211> 1143
      <212> DNA
      <213> Homo sapiens


      <400> 1725
 tttcgtggct ccccgctccc attgtctcgg cagatgccgc ctggtccagc tatcgtgctc     60
 ggtattcagt tttccggagc agcgctcttt ctctggcccg cggagcggtc ccgcggccga    120
 gtaccggatt cccgagtttg ggaggctctg ctttcctcct taggacccac tttgccgtcc    180
 tggggtggct gcagttatgt ccgcgctgcg acctctcctg cttctgctgc tgcctctgtg    240
 tcccggtcct ggtcccggac ccgggagcga ggcaaaggtc acccggagtt gtgcagagac    300
 ccggcaggtg ctgggggccc ggggatatag cttaaaccta atccctcccg ccctgatctc    360
 aggtgagcac ctccgggtct gtccccagga gtacacctgc tgttccagtg agacagagca    420
 gaggctgatc agggagactg aggccacctt ccgaggcctg gtggaggaca gcggctcctt    480
 tctggttcac acactggctg ccaggcacag aaaatttgat gagttttttc tggagatgct    540
 tttcgaaacc ctagcattct tttgcccaga tctttcttcc cattctacgg gcgcctgatt    600
 gccccacacg ccctcatata tcatggcctg ttctctcggc tgcgagactt ctatccccca    660
 tgtggtgagg ggctgccaga ccccctcgcc gaattctggc cgcaacctcc tggcgagaaa    720
 gtgtccgctt gtgcagcccc agaaccacat cccccctgac tacacgtctt gctttaccaa    780
 gtggcacatt gtttaggggc tcccaataag gatcccattt tactaagtgt ggcggctttt    840
 gggcccccaa ccatgaggag acaggaactg tggttatcac cctcaactaa gacccatgat    900
 aagagcaaca cgtctatcgg agcgcgacgg aaggagttct accgaccgac cgcctactcg    960
 cgactaggta ggacgacaca cagaatgaac gatgaagaac tcagctcgat cgtcgggggc   1020
 agcttctact caccgcagat gtgcgcatcc tcgagcgacg tactacagta gctaggctgt   1080
 taggtaccgc acgcaaatat cgatgcacca tacttaagga tgacagatac gtacgttagt   1140
 cac                                                                 1143



      <210> 1726
      <211> 2186
      <212> DNA
      <213> Homo sapiens


      <400> 1726
 tttttttttt ttaataaact agcagcttta ttgcccttca ggggccatgt cttcacttga     60
 gatgtcgaat tgcttgaggg aggaaaacct gtaagaaatg atggagatca gggaacaggc    120
 cttggggatc ctggagcggg gtcacagtga gcattcggtc agccggggag acagacgcca    180
 caaagctcag caggggctca gtttctggcc tctcttcgcc accactcagt cctttcagct    240
 cctgggtgac ctgagcctca gtcgccagcc accctgctct tgtgccagcg ccacctccag    300
 ctccctcctt ggtttgctgc tgcaagcgtc tacgggctcg ccgccgccct tgccacactc    360
 ggtgccacaa ggcacagcgc cagctcgctg aggagggcag ggatgccccc ttccctgcct    420
 caccctgaga ccattcttgg gctgcctcat gtcccttggg cccccgctct gccagggctg    480
 cgtggctggg ctgcccctct tctccagggg ctccatgctt tccagtggtc aggggcaggt    540
 cccctggctg cccagggctc tgcatggccc agtcctgcac catctctcca acctctataa    600
 ccatctcttc taccctgtct tccccaccgt cccctgcaca tccctgctgc tcctctttcc    660
 cctcctcaca gcagtttttc tgtccatcta ctttgagtct tttgcttgtc cctccctgag    720
 aggactcccc agttccacct ccttctgacc gcgttctctt ggttgcctgt tctatatggc    780
 accccagtgc ttccctgaat acctgcacca gggcagcagt gagctgggtg aagggtgcaa    840
 ggggtaaagg gatcggcgta gcagagagca gggagctggg ggagctgggc tgcagaagag    900
 ggagcagccc ccagtcccga ccccgggagg aacggcgctg gtactggagg cttcggcagt    960
 aattggctgc tgctcggcag cagttctgta ggcgcccagc cacccggctg gtcacattgg   1020
 ctgcgacatt gtgactcagg tcaaaagggt cctggagatt cagggggcca aggcgcagac   1080
 cctcccagag attagaaggc aggccccctg ccacaggcag tgcctgaccc tcccgcaggg   1140
 acagcaggga gccacgaaga tcccaacaag atacacagga gaagaactgg gctagcaggg   1200
 aactgagggg ctccacattt atgctgggct ccagtcttga ggcatccctg gggaaactgc   1260
 agtcccagcc atcgacttcc acctgttccc cctctcctgc tttctgggtg agctgggaca   1320
 cagtgggcaa cacaggaggg tccctggtct gaagaaaata gatcaccagc aaggtcaggg   1380
 cgtagttact gagaaggggg ccactccctg acagcccccg accctgagcc cagcagcgga   1440
 gggtgtacac gaggggccgg actcgaccat ccagctcaga gcagagactc aggaaacggg   1500
 agttatgcag ggccagccgg ttactgaggg agacatcacc gtggagacct gaaggccgat   1560
 gacagaactt gaccacaggg cgccgggcag agggcacagt ttggactcga tacaccccag   1620
 ggacacagcc ccggagaatg gatcccacca gctccagcat tgctgccccc tctgctttct   1680
 cctcctttgg ggtctctgct agttccgagg ccttccccag gtccccctct tccctgtcct   1740
 ctagcagtgg tgaagctgga ggcagagact ggggagaagc aagggtctcg gaggccaagg   1800
 cagagtccgg agtttggggc gccagggagg aggaaggggt ttcaaagtcc agggcttcag   1860
 aatcctgggg agaagcagga ggttgtgaat ctggagggga agctggggtg caggccaggg   1920
 cttgagggtc cagtggggaa gccagggccg agtccagcga tggagattct ggagcctttg   1980
 ggactggctg tggacagaaa tgaactgagt gaaatgtttc tgctgttccc taagcaggga   2040
 tctctcaaga taatattact tccagcttat tcagctctat tctaaggtct ttatacatat   2100
 taactcattt aatcttcaca ggaacccttt ttttttttaa agataacctt ttaattctat   2160
 aaaataaaag gtctacctct gcaaaa                                        2186



      <210> 1727
      <211> 584
      <212> DNA
      <213> Homo sapiens


      <400> 1727
 tttcgttgtc catgtgcaga gaggtgcacg tgtatgaata tatcccatcc gtgcggcaga     60
 cggagctgtg ccactaccac gagctgtact acgacgcagc ctgcaccctc ggggcgtacc    120
 acccactact ctatgagaag ctcctggtgc agcgcctgaa catgggcacg cagggggatt    180
 tgcatcgcaa gggcaaggtg gttcttcccg gcttccaggc ggtgcactgc cctgcaccaa    240
 gtccagtcat tccacactct taaaaagggt ttcttgggaa tcaatgtgca ataaggtact    300
 actgttgtac tcaaagtcac aaaagaatac ttgaagatag attttagaca gtgtagtttt    360
 gagtctttaa acagtaattt agtggtggtc atgataatcc ttctctttct aagccattga    420
 gtatgtatta ctgctttgaa catagaaatg gtttttttaa aaaaataagg ctcaagaaag    480
 atgcaaaacc aaggatagct agaaagaaaa cacatgtatg accatgggta tgatacctcc    540
 agaaatggtt aacaacttat tcttctgcca tggagtaccc cctc                     584



      <210> 1728
      <211> 1971
      <212> DNA
      <213> Homo sapiens


      <400> 1728
 tttcgtcctt gagcccagtg ggtcaaggct gctttgagcc gtgatcatgc cactgtactc     60
 cagtctgggc aacgggaaga ctctgtaaaa gcgaatgatt aaaaataagt gttgggatta    120
 tattttcttt ggatttctct tttctattta aagattgccc tatcagaatc ccatcttcat    180
 ttttttgttc tttctgacat aggttttcaa gggacatgag tgacccgagg atggtgttga    240
 gcctctcttt gtaagggttg tttctttgtt actcacgtac tggtaattat cttaccatct    300
 ctgcagagcc cacccacctt tgggttcctg ttggacatcg atggagtgct tgtgcggggc    360
 cacagagtga tccctgctgc tctgaaagcc ttccgaaggc tggtgaactc ccaggggcag    420
 ctgcgggtgc ccgtggtttt tgttacaaat gctgggaaca tcttacaaca cagcaaagcc    480
 caggagctgt cagccctgct ggggtgcgag gtggatgcag accaagttat cctctctcac    540
 agccccatga agctcttctc cgagtaccat gagaagcgga tgctggtgtc tggacagggg    600
 cccgtgatgg aaaatgccca gggactgggc ttccgaaatg tcgtcaccgt ggatgagctg    660
 cggatggcct ttcctctgct tgacatggtg gacctggagc ggcggctaaa gaccacgccc    720
 ctcccgagga atgacttccc ccgcattgaa ggggtgctcc tcctagggga gccggtccgc    780
 tgggagacca gcctgcagct gatcatggat gtcctcctca gcaatgggag ccctggggct    840
 ggcctggcaa caccccccta cccccacctc cccgtcctag ccagcaacat ggatctcctg    900
 tggatggctg aagccaagat gcccaggttt ggacatggca cctttctgct gtgcctggaa    960
 accatttacc agaaagtgac gggcaaggag ctgagatacg agggcctgat gggcaaaccc   1020
 agcatcctca cttaccagta tgccgaggac ctgatcaggc gacaggcgga gaggcggggc   1080
 tgggccgccc ccatccggaa gctctatgct gtgggtgata accctatgtc tgacgtatac   1140
 ggcgccaacc tgttccacca gtacctgcag aaggcaacgc atgatggggc gccagaacta   1200
 ggggccgggg gcacacggca gcaacagccc tcagcaagcc agagctgcat ctccatcctg   1260
 gtgtgtacag gcgtctacaa tcccaggaac ccacagtcca cggagcctgt ccttggagga   1320
 ggggagcctc cattccacgg gcaccgagac ttatgcttca gtccagggct catggaggcc   1380
 tcccacgtgg tgaatgacgt gaatgaggct gtgcagctgg tcttccgcaa ggagggctgg   1440
 gctttggagt gagggcagtg cggtggaggt gagggggtga gcctggacct gtgggcgagt   1500
 cccattggct gggctctggc ctgatcactg ggctcaggtc agggcttggt tcccttgcca   1560
 cccttcttgc tgccccatga gtgtggcatt actggtcact tggaagaaga cagtgactct   1620
 ttttccctgc tgggtagcat tttgtatgga acggttggaa ttttctgggc ccagttccca   1680
 cgtgcctttc gtggcagtct aacctcaggc cattctcttc ccctgtgtgc ctcagtgtcc   1740
 ttctcatttc agtagggact tctgaaatgg gggaggcagt gtggaatact gtggatgtct   1800
 gtgcagagcc tttgccggca ctgaaggcat gcagcctgtc ggcagagtgt cttaacacca   1860
 gatgctactt tttactgtat tgtagtttat tgcccggaga tgtggggctt tttttttaaa   1920
 taaaataatc ataataaatg ttcatgatgc tgactcttgt gaaaaaaaaa a            1971



      <210> 1729
      <211> 1971
      <212> DNA
      <213> Homo sapiens


      <400> 1729
 tttcgtcctt gagcccagtg ggtcaaggct gctttgagcc gtgatcatgc cactgtactc     60
 cagtctgggc aacgggaaga ctctgtaaaa gcgaatgatt aaaaataagt gttgggatta    120
 tattttcttt ggatttctct tttctattta aagattgccc tatcagaatc ccatcttcat    180
 ttttttgttc tttctgacat aggttttcaa gggacatgag tgacccgagg atggtgttga    240
 gcctctcttt gtaagggttg tttctttgtt actcacgtac tggtaattat cttaccatct    300
 ctgcagagcc cacccacctt tgggttcctg ttggacatcg atggagtgct tgtgcggggc    360
 cacagagtga tccctgctgc tctgaaagcc ttccgaaggc tggtgaactc ccaggggcag    420
 ctgcgggtgc ccgtggtttt tgttacaaat gctgggaaca tcttacaaca cagcaaagcc    480
 caggagctgt cagccctgct ggggtgcgag gtggatgcag accaagttat cctctctcac    540
 agccccatga agctcttctc cgagtaccat gagaagcgga tgctggtgtc tggacagggg    600
 cccgtgatgg aaaatgccca gggactgggc ttccgaaatg tcgtcaccgt ggatgagctg    660
 cggatggcct ttcctctgct tgacatggtg gacctggagc ggcggctaaa gaccacgccc    720
 ctcccgagga atgacttccc ccgcattgaa ggggtgctcc tcctagggga gccggtccgc    780
 tgggagacca gcctgcagct gatcatggat gtcctcctca gcaatgggag ccctggggct    840
 ggcctggcaa caccccccta cccccacctc cccgtcctag ccagcaacat ggatctcctg    900
 tggatggctg aagccaagat gcccaggttt ggacatggca cctttctgct gtgcctggaa    960
 accatttacc agaaagtgac gggcaaggag ctgagatacg agggcctgat gggcaaaccc   1020
 agcatcctca cttaccagta tgccgaggac ctgatcaggc gacaggcgga gaggcggggc   1080
 tgggccgccc ccatccggaa gctctatgct gtgggtgata accctatgtc tgacgtatac   1140
 ggcgccaacc tgttccacca gtacctgcag aaggcaacgc atgatggggc gccagaacta   1200
 ggggccgggg gcacacggca gcaacagccc tcagcaagcc agagctgcat ctccatcctg   1260
 gtgtgtacag gcgtctacaa tcccaggaac ccacagtcca cggagcctgt ccttggagga   1320
 ggggagcctc cattccacgg gcaccgagac ttatgcttca gtccagggct catggaggcc   1380
 tcccacgtgg tgaatgacgt gaatgaggct gtgcagctgg tcttccgcaa ggagggctgg   1440
 gctttggagt gagggcagtg cggtggaggt gagggggtga gcctggacct gtgggcgagt   1500
 cccattggct gggctctggc ctgatcactg ggctcaggtc agggcttggt tcccttgcca   1560
 cccttcttgc tgccccatga gtgtggcatt actggtcact tggaagaaga cagtgactct   1620
 ttttccctgc tgggtagcat tttgtatgga acggttggaa ttttctgggc ccagttccca   1680
 cgtgcctttc gtggcagtct aacctcaggc cattctcttc ccctgtgtgc ctcagtgtcc   1740
 ttctcatttc agtagggact tctgaaatgg gggaggcagt gtggaatact gtggatgtct   1800
 gtgcagagcc tttgccggca ctgaaggcat gcagcctgtc ggcagagtgt cttaacacca   1860
 gatgctactt tttactgtat tgtagtttat tgcccggaga tgtggggctt tttttttaaa   1920
 taaaataatc ataataaatg ttcatgatgc tgactcttgt gaaaaaaaaa a            1971



      <210> 1730
      <211> 359
      <212> DNA
      <213> Homo sapiens


      <400> 1730
 atctcaggag aatccattta ctggagccag aaacctactc catcatcgaa cgccagccct     60
 tggtctgagc ctgcggctgt agatgtggaa ctcacagcat atgcattgtt ggcccagctt    120
 accaagccca gcctgactca aaaggagata gcgaaggcca ctagcatagt ggcttggttg    180
 gccaagcaac gcaatgcata tgggggcttc tcttctactc aggatactgt agttgctctc    240
 caagctcttg ccaaatatgc cactaccgcc tacgtgccat ctgaggagat caacctggtt    300
 gtaaaatcca ctgagaattt ccagcgcaca ttcaacatac aggcagttaa ccgaatggg     359



      <210> 1731
      <211> 359
      <212> DNA
      <213> Homo sapiens


      <400> 1731
 atctcaggag aatccattta ctggagccag aaacctactc catcatcgaa cgccagccct     60
 tggtctgagc ctgcggctgt agatgtggaa ctcacagcat atgcattgtt ggcccagctt    120
 accaagccca gcctgactca aaaggagata gcgaaggcca ctagcatagt ggcttggttg    180
 gccaagcaac gcaatgcata tgggggcttc tcttctactc aggatactgt agttgctctc    240
 caagctcttg ccaaatatgc cactaccgcc tacgtgccat ctgaggagat caacctggtt    300
 gtaaaatcca ctgagaattt ccagcgcaca ttcaacatac aggcagttaa ccgaatggg     359



      <210> 1732
      <211> 359
      <212> DNA
      <213> Homo sapiens


      <400> 1732
 atctcaggag aatccattta ctggagccag aaacctactc catcatcgaa cgccagccct     60
 tggtctgagc ctgcggctgt agatgtggaa ctcacagcat atgcattgtt ggcccagctt    120
 accaagccca gcctgactca aaaggagata gcgaaggcca ctagcatagt ggcttggttg    180
 gccaagcaac gcaatgcata tgggggcttc tcttctactc aggatactgt agttgctctc    240
 caagctcttg ccaaatatgc cactaccgcc tacgtgccat ctgaggagat caacctggtt    300
 gtaaaatcca ctgagaattt ccagcgcaca ttcaacatac aggcagttaa ccgaatggg     359



      <210> 1733
      <211> 359
      <212> DNA
      <213> Homo sapiens


      <400> 1733
 atctcaggag aatccattta ctggagccag aaacctactc catcatcgaa cgccagccct     60
 tggtctgagc ctgcggctgt agatgtggaa ctcacagcat atgcattgtt ggcccagctt    120
 accaagccca gcctgactca aaaggagata gcgaaggcca ctagcatagt ggcttggttg    180
 gccaagcaac gcaatgcata tgggggcttc tcttctactc aggatactgt agttgctctc    240
 caagctcttg ccaaatatgc cactaccgcc tacgtgccat ctgaggagat caacctggtt    300
 gtaaaatcca ctgagaattt ccagcgcaca ttcaacatac aggcagttaa ccgaatggg     359



      <210> 1734
      <211> 359
      <212> DNA
      <213> Homo sapiens


      <400> 1734
 atctcaggag aatccattta ctggagccag aaacctactc catcatcgaa cgccagccct     60
 tggtctgagc ctgcggctgt agatgtggaa ctcacagcat atgcattgtt ggcccagctt    120
 accaagccca gcctgactca aaaggagata gcgaaggcca ctagcatagt ggcttggttg    180
 gccaagcaac gcaatgcata tgggggcttc tcttctactc aggatactgt agttgctctc    240
 caagctcttg ccaaatatgc cactaccgcc tacgtgccat ctgaggagat caacctggtt    300
 gtaaaatcca ctgagaattt ccagcgcaca ttcaacatac aggcagttaa ccgaatggg     359



      <210> 1735
      <211> 446
      <212> DNA
      <213> Homo sapiens


      <400> 1735
 tccaaccagt tgtaaggaga atggagagtg cagtgagagt ggagtccggg gtcctggtcg     60
 gggtggtctg tctgctcctg gcatgccctg ccacagccac tgggcccgaa gttgctcagc    120
 ctgaagtaga caccaccctg ggtcgtgtgc gaggccggca ggtgggcgtg aagggcacag    180
 accgccttgt gaatgtcttt ctgggcattc catttgccca gccgccactg ggccctgacc    240
 ggttctcagc cccacaccca gcacagccct gggagggtgt gcgggatgcc agcactgcgc    300
 ccccaatgtg cctacaagac gtggagagca tgaacagcag cagatttgtc ctcaacggaa    360
 aacagcagat cttctccgtt tcagaggact gcctggtcct caacgtctat agcccagctg    420
 aggtccccgc agggtccggt aggccg                                         446



      <210> 1736
      <211> 318
      <212> DNA
      <213> Homo sapiens


      <400> 1736
 gtgacctgga gtgaaacaga atctacataa cctaagccca tatactctgc actgtgtaaa     60
 ggaaaaggga gaaatgtatt atacttgaga cattgcacct accccggaag gctggaaata    120
 cggaaacagc atggagttgc aagtcctctg aagacaatga gaggatttag gatgagcccg    180
 ataggtgtgg cagaccaaat ggacatttct ctaaattcaa ggcggtattc aacggagtgc    240
 agtagtttgg cttgtcagaa ggcacgtagc ctggcagaca caaacacttg taggaaccat    300
 cggtggtcga cgcggccg                                                  318



      <210> 1737
      <211> 1084
      <212> DNA
      <213> Homo sapiens


      <400> 1737
 cagtgcggtg gaattccagc ccagcctcgg tgtccagcag cccggcccgc gcgctcctgc     60
 tggtcggcgt cttcctcctg gcctactggt tcttgtccct gaccctgggc ttcactttca    120
 gcgtcctgca cgtggtgttc ggccgcttct tctggatcgt gcgggtcgtc ctgttttcca    180
 tgtcctgcgt gtacatcctg cacaagtacg agggcgagcc ggagaacgcg gtgctgccgc    240
 tgtgcttcgt ggtggccgtc tacttcatga ccgggcccat gggcttctac tggcgaagca    300
 gtcccagcgg ccccagcaac cccagcaacc ccagcgtgga ggagaagctg gagcacctgg    360
 agaagcaggt cagactgctc aacatccgtc tcaaccgggt gctcgagagc ctggaccgct    420
 ccaaggacaa gtgaaggtca gccggccggg cgggtccaca gttaccagca cgctgtctca    480
 gaaaacgaaa acggaggaaa aaaaccccaa accccaaaca atcttaataa acacgactga    540
 gcaagaaagt ggcgctgtgt aaggctattt ccacccaccc ggcagctctt aggacacatt    600
 cccagaagag cggaaagatc attgacgtgg aactacacac gaagtgtaat tagtggggga    660
 aaaaatattt tttaaacaaa ggatataacc atatttagtt gtacagtaag agaaatttat    720
 ctgtgcatag agcataaagt taattttttc aagcatttaa atacatcttt tgtaaggttt    780
 tttaataaag gcagattgag tcaagtttat taaaacttta catggagggg aagaatatgc    840
 taatttgaca tttgagaaaa gtttaaatgc gagcgtttgt tttcacagct tagggattgg    900
 tgggtgaggt ctgtgtgcgt tattttcatg ttcccaaact gtgagcttta tttcatgtta    960
 tttttggtgg atgttgactt agttcatgaa tgttgtcact tctaaatgtg gacagttggg   1020
 ctgcaggatg caactcaacc tcttttggat cctagagacc cctgccaagc ccccatcagt   1080
 ccta                                                                1084



      <210> 1738
      <211> 813
      <212> DNA
      <213> Homo sapiens


      <400> 1738
 cgacccacgc gtccgagaac gcccacggcc aggcctcctc cttcgccaat ttcctcgtcc     60
 gcacttacct ggggaaggat gctggcttcg attcagagat cttcaaaaga tcgacgtttg    120
 gccccagcgt ggaattcacc tcggtgctga agccagtctt tgctcgtgag aaggaaccct    180
 tctccctgtc atgcttgttt tcggaagatg tgttagatgc tgagagcatc cagtggttcc    240
 gagatgggag cctactgagg tcctcgagac gtcggaagat cctctacaca gaccgccagg    300
 catccctgaa ggtgtcctgc acctacaagg aggacgaggg gctctacatg gtccgggtgc    360
 cctcgccctt cggaccccgg gaacagagca cctacgtgct tgtgagagat gccgaggccg    420
 agaaccccgg ggccccaggc tccccactga acgtccgatg cctggatgtg aacagagact    480
 gcctcatcct gacttgggcc ccgcccagtg acacccgggg caaccccatc actgcctaca    540
 ccattgagcg gtgccagggc gagtctgggg aatggatcgc ctgccatgag gcccccggag    600
 ggacttgtcg gtgcccaatc caaggcctcg tcgaaggtca gagctatcgg ttccgggtga    660
 gagccatcag cagggtaggc agcagcgtcc cctccaaggc ctcagagttg gttgtcatgg    720
 gtgaccatga tgcagcccgg aggaagacag agatcccctt tgatctggga aacaagatca    780
 ccatcagcac agacgctttt gaagatactg tgg                                 813



      <210> 1739
      <211> 883
      <212> DNA
      <213> Homo sapiens


      <400> 1739
 gaagcagcac cctggagaaa atcatttcac aagcaaagtg ggccgagcct tgtttgtgaa     60
 gacctgcaca ttccatgtgt caggggagcc ttccacctgc agagaatttg ggaaggactt    120
 cctggccaag ttgggatttc tccatcaaca ggctgctcac actggggagc aatccaatag    180
 caaaagcgac ggtggggcca tcagtcacag aggaaaaact cattacaact gtggagaaca    240
 cacaaaagca ttcagcggta tgtgtgaact gcattgcacc ttttgccctg cccagggccc    300
 atgtcagatt tatgtctctg ctgatactat agtggaagcc attttacctc taccgcctgg    360
 caggtgacca ccagtgtgca ccactcgccc attcccatgg gtgtacaagt aagggtaacc    420
 ctcagggttc gggttaaggg aggagtttgt taaaagccta agcaggtagt tcgggtgttt    480
 tttaatcctt tctgatgagt taggccatgg acctgaccca gtttggtcca gaggactctg    540
 ctggtgacct gaaaagaggg actacatatt tcaggatatt gttggtctca catgactctt    600
 gatagagttt gccagccttc aaatcaccaa ctgtgggaac caactgcctc ttattgcctt    660
 gctgtgttca attacaaaaa aagatggaaa agactgttat gaagccagat gaacctttct    720
 ccagtcttcc ttcactattt ttttttcctt caccatttat catttcatag tcatttatgt    780
 ttcatcggtc ctcatgtgta ctagtgggtt attttactta tactcccgga tatcatatta    840
 tttaatgcat agcctcttca gaatgcaatt ttaaaatgta aag                      883



      <210> 1740
      <211> 883
      <212> DNA
      <213> Homo sapiens


      <400> 1740
 gaagcagcac cctggagaaa atcatttcac aagcaaagtg ggccgagcct tgtttgtgaa     60
 gacctgcaca ttccatgtgt caggggagcc ttccacctgc agagaatttg ggaaggactt    120
 cctggccaag ttgggatttc tccatcaaca ggctgctcac actggggagc aatccaatag    180
 caaaagcgac ggtggggcca tcagtcacag aggaaaaact cattacaact gtggagaaca    240
 cacaaaagca ttcagcggta tgtgtgaact gcattgcacc ttttgccctg cccagggccc    300
 atgtcagatt tatgtctctg ctgatactat agtggaagcc attttacctc taccgcctgg    360
 caggtgacca ccagtgtgca ccactcgccc attcccatgg gtgtacaagt aagggtaacc    420
 ctcagggttc gggttaaggg aggagtttgt taaaagccta agcaggtagt tcgggtgttt    480
 tttaatcctt tctgatgagt taggccatgg acctgaccca gtttggtcca gaggactctg    540
 ctggtgacct gaaaagaggg actacatatt tcaggatatt gttggtctca catgactctt    600
 gatagagttt gccagccttc aaatcaccaa ctgtgggaac caactgcctc ttattgcctt    660
 gctgtgttca attacaaaaa aagatggaaa agactgttat gaagccagat gaacctttct    720
 ccagtcttcc ttcactattt ttttttcctt caccatttat catttcatag tcatttatgt    780
 ttcatcggtc ctcatgtgta ctagtgggtt attttactta tactcccgga tatcatatta    840
 tttaatgcat agcctcttca gaatgcaatt ttaaaatgta aag                      883



      <210> 1741
      <211> 449
      <212> DNA
      <213> Homo sapiens


      <400> 1741
 tcccgggggc cccacgcgtc cgcttggaaa cccacccaga acctttaccc tctgacacca     60
 tggtcagctc ctgttgtggt tccgtctgct ctgaccaggg ctgtggcctg gagacctgct    120
 gccgccccag ctgctgtcag accacctgct gcaggaccac ctgctgccgc cccagctgct    180
 gtgtgtccag ctgctgcaga ccccagtgct gccagtctgt gtgctgccag cccacctgct    240
 gccgtcccag ctgctgtccc agctgctgtc agaccacctg ctgcaggacc acctgctgcc    300
 gccctagctg ctgtgtatcc agctgctgca gaccccagtg ctgccagtct gtgtgctgcc    360
 agcccacttg ctgccgtccc agctgcagca tctccagctg ctgtcgcccc agctgctgtg    420
 tgtccaggtg ctgcaggtcc cagcgctgc                                      449



      <210> 1742
      <211> 449
      <212> DNA
      <213> Homo sapiens


      <400> 1742
 tcccgggggc cccacgcgtc cgcttggaaa cccacccaga acctttaccc tctgacacca     60
 tggtcagctc ctgttgtggt tccgtctgct ctgaccaggg ctgtggcctg gagacctgct    120
 gccgccccag ctgctgtcag accacctgct gcaggaccac ctgctgccgc cccagctgct    180
 gtgtgtccag ctgctgcaga ccccagtgct gccagtctgt gtgctgccag cccacctgct    240
 gccgtcccag ctgctgtccc agctgctgtc agaccacctg ctgcaggacc acctgctgcc    300
 gccctagctg ctgtgtatcc agctgctgca gaccccagtg ctgccagtct gtgtgctgcc    360
 agcccacttg ctgccgtccc agctgcagca tctccagctg ctgtcgcccc agctgctgtg    420
 tgtccaggtg ctgcaggtcc cagcgctgc                                      449



      <210> 1743
      <211> 449
      <212> DNA
      <213> Homo sapiens


      <400> 1743
 tcccgggggc cccacgcgtc cgcttggaaa cccacccaga acctttaccc tctgacacca     60
 tggtcagctc ctgttgtggt tccgtctgct ctgaccaggg ctgtggcctg gagacctgct    120
 gccgccccag ctgctgtcag accacctgct gcaggaccac ctgctgccgc cccagctgct    180
 gtgtgtccag ctgctgcaga ccccagtgct gccagtctgt gtgctgccag cccacctgct    240
 gccgtcccag ctgctgtccc agctgctgtc agaccacctg ctgcaggacc acctgctgcc    300
 gccctagctg ctgtgtatcc agctgctgca gaccccagtg ctgccagtct gtgtgctgcc    360
 agcccacttg ctgccgtccc agctgcagca tctccagctg ctgtcgcccc agctgctgtg    420
 tgtccaggtg ctgcaggtcc cagcgctgc                                      449



      <210> 1744
      <211> 2031
      <212> DNA
      <213> Homo sapiens


      <400> 1744
 gtccggaaat tctgcgaaga cccacgcgtc cgactaagct tgcctaattt gcttcagaat     60
 tggaagaggg aattgcagca ggaaaatatg tgaagagttt ttaaacccac aaattcttct    120
 tactttagaa ttagttgtta cattggcagg aaaaaataaa tgcagatgtt ggaccatgtt    180
 ggaaaccttg tcaagacagt ggattgtctc acacagaatg gaaatgtggc ttctgattct    240
 ggtggcgtat atgttccaga gaaatgtgaa ttcagtacat atgccaacta aagctgtgga    300
 cccagaagca ttcatgaata ttagtgaaat catccaacat caaggctatc cctgtgagga    360
 atatgaagtc gcaactgaag atgggtatat cctttctgtt aacaggattc ctcgaggcct    420
 agtgcaacct aagaagacag gttccaggcc tgtggtgtta ctgcagcatg gcctagttgg    480
 aggtgctagc aactggattt ccaacctgcc caacaatagc ctgggcttca ttctggcaga    540
 tgctggtttt gacgtgtgga tggggaacag caggggaaac gcctggtctc gaaaacacaa    600
 gacactctcc atagaccaag atgagttctg ggctttcagt tatgatgaga tggctaggtt    660
 tgaccttcct gcagtgataa actttatttt gcagaaaacg ggccaggaaa agatctatta    720
 tgtcggctat tcacagggca ccaccatggg ctttattgca ttttccacca tgccagagct    780
 ggctcagaaa atcaaaatgt attttgcttt agcacccata gccactgtta agcatgcaaa    840
 aagccccggg accaaatttt tgttgctgcc agatatgatg atcaagggat tgtttggcaa    900
 aaaagaattt ctgtatcaga ccagatttct cagacaactt gttatttacc tttgtggcca    960
 ggtgattctt gatcagattt gtagtaatat catgttactt ctgggtggat tcaacaccaa   1020
 caatatgaac atgagccgag caagtgtata tgctgcccac actcttgctg gaacatctgt   1080
 gcaaaatatt ctacactgga gccaggcagt gaattctggt gaactccggg catttgactg   1140
 ggggagtgag accaaaaatc tggaaaaatg caatcagcca actcctgtaa ggtacagagt   1200
 cagagatatg acggtcccta cagcaatgtg gacaggaggt caggactggc tttcaaatcc   1260
 agaagacgtg aaaatgctgc tctctgaggt gaccaacctc atctaccata agaatattcc   1320
 tgaatgggct catgtggatt tcatctgggg tttggatgct cctcaccgta tgtacaatga   1380
 aatcatccat ctgatgcatc aagaggagac acaacctttc ccaaggacgg cgtgaggccg   1440
 tattgtgaag catctgacac tgacgatctt atgacaacct cctgagggat ggggctagga   1500
 cccatgaagg cagaattatg gagagcagag acctagtata catttttcag attccctgca   1560
 cttggcacta aatccgacac ttacatttac attttttttc tgtaaattaa agtacttatt   1620
 aggtaaatag aggttttgta tgctattata tattctacca tcttgaaggg taggttttac   1680
 ctgatagcca gaaaatatct agacattctc tatatcattc aggtaaatct ctttaaaaca   1740
 cctattgttt tttctataag ccatattttt ggagcactaa agtaaaatgg caaattggga   1800
 cagatattga ggtctggagt ctgtggatta ttgttgactt tgacaaaata agctagacat   1860
 tttcaccttg ttgccacaga gacataacac tacctcagga agctgagctg ctttaaggac   1920
 aacaacaaca aaatcagtgt tacagtatgg atgaaatcta tgttaagcat tctcagaata   1980
 aggccaagtt ttatagttgc atctcaggga agaaaatttt ataggatgtt c            2031



      <210> 1745
      <211> 2031
      <212> DNA
      <213> Homo sapiens


      <400> 1745
 gtccggaaat tctgcgaaga cccacgcgtc cgactaagct tgcctaattt gcttcagaat     60
 tggaagaggg aattgcagca ggaaaatatg tgaagagttt ttaaacccac aaattcttct    120
 tactttagaa ttagttgtta cattggcagg aaaaaataaa tgcagatgtt ggaccatgtt    180
 ggaaaccttg tcaagacagt ggattgtctc acacagaatg gaaatgtggc ttctgattct    240
 ggtggcgtat atgttccaga gaaatgtgaa ttcagtacat atgccaacta aagctgtgga    300
 cccagaagca ttcatgaata ttagtgaaat catccaacat caaggctatc cctgtgagga    360
 atatgaagtc gcaactgaag atgggtatat cctttctgtt aacaggattc ctcgaggcct    420
 agtgcaacct aagaagacag gttccaggcc tgtggtgtta ctgcagcatg gcctagttgg    480
 aggtgctagc aactggattt ccaacctgcc caacaatagc ctgggcttca ttctggcaga    540
 tgctggtttt gacgtgtgga tggggaacag caggggaaac gcctggtctc gaaaacacaa    600
 gacactctcc atagaccaag atgagttctg ggctttcagt tatgatgaga tggctaggtt    660
 tgaccttcct gcagtgataa actttatttt gcagaaaacg ggccaggaaa agatctatta    720
 tgtcggctat tcacagggca ccaccatggg ctttattgca ttttccacca tgccagagct    780
 ggctcagaaa atcaaaatgt attttgcttt agcacccata gccactgtta agcatgcaaa    840
 aagccccggg accaaatttt tgttgctgcc agatatgatg atcaagggat tgtttggcaa    900
 aaaagaattt ctgtatcaga ccagatttct cagacaactt gttatttacc tttgtggcca    960
 ggtgattctt gatcagattt gtagtaatat catgttactt ctgggtggat tcaacaccaa   1020
 caatatgaac atgagccgag caagtgtata tgctgcccac actcttgctg gaacatctgt   1080
 gcaaaatatt ctacactgga gccaggcagt gaattctggt gaactccggg catttgactg   1140
 ggggagtgag accaaaaatc tggaaaaatg caatcagcca actcctgtaa ggtacagagt   1200
 cagagatatg acggtcccta cagcaatgtg gacaggaggt caggactggc tttcaaatcc   1260
 agaagacgtg aaaatgctgc tctctgaggt gaccaacctc atctaccata agaatattcc   1320
 tgaatgggct catgtggatt tcatctgggg tttggatgct cctcaccgta tgtacaatga   1380
 aatcatccat ctgatgcatc aagaggagac acaacctttc ccaaggacgg cgtgaggccg   1440
 tattgtgaag catctgacac tgacgatctt atgacaacct cctgagggat ggggctagga   1500
 cccatgaagg cagaattatg gagagcagag acctagtata catttttcag attccctgca   1560
 cttggcacta aatccgacac ttacatttac attttttttc tgtaaattaa agtacttatt   1620
 aggtaaatag aggttttgta tgctattata tattctacca tcttgaaggg taggttttac   1680
 ctgatagcca gaaaatatct agacattctc tatatcattc aggtaaatct ctttaaaaca   1740
 cctattgttt tttctataag ccatattttt ggagcactaa agtaaaatgg caaattggga   1800
 cagatattga ggtctggagt ctgtggatta ttgttgactt tgacaaaata agctagacat   1860
 tttcaccttg ttgccacaga gacataacac tacctcagga agctgagctg ctttaaggac   1920
 aacaacaaca aaatcagtgt tacagtatgg atgaaatcta tgttaagcat tctcagaata   1980
 aggccaagtt ttatagttgc atctcaggga agaaaatttt ataggatgtt c            2031



      <210> 1746
      <211> 1042
      <212> DNA
      <213> Homo sapiens


      <400> 1746
 tacaactttg ccagcactac agcctaagct tccagagtgg acacggagaa gggcatcaga     60
 aaaccattct ggtgaggtcc acacccataa gtcaccatgt acaaggactg catcgagtcc    120
 actggagact attttcttct ctgtgacgcc gaggggccat ggggcatcat tctggagtcc    180
 ctggccatac ttggcatcgt ggtcacaatt ctgctactct tagcatttct cttcctcatg    240
 cgaaagatcc aagactgcag ccagtggaat gtcctcccca cccagctcct cttcctcctg    300
 agtgtcctgg ggctcttcgg actcgctttt gccttcatca tcgagctcaa tcaacaaact    360
 gcccccgtac gctactttct ctttggggtt ctctttgctc tctgtttctc atgcctctta    420
 gctcatgcct ccaatctagt gaagctggtt cggggttgtg tctccttctc ctggacgaca    480
 attctgtgca ttgctattgg ttgcagtctg ttgcaaatca ttattgccac tgagtatgtg    540
 actctcatca tgaccagagg tatgatgttt gtgaatatga caccctgcca gctcaatgtg    600
 gactttgttg tactcctggt ctatgtcctc ttcctgatgg ccctcacatt cttcgtctcc    660
 aaagccacct tctgtggccc gtgtgagaac tggaagcagc atggaaggct catctttatc    720
 actgtgctct tctccatcat catctgggtg gtgtggatct ccatgctcct gagaggcaac    780
 ccgcagttcc agcgacagcc ccagtgggac gacccggtcg tctgcattgc tctggtcacc    840
 aacgcatggg ttttcctgct gctgtacatc gtccctgagc tctgcattct ctacagatcg    900
 tgtagacagg agtgcccttt acaaggcaat gcctgccccg tcacagccta ccaacacagc    960
 ttccaagtgg agaaccagga gctctccaga gataaatgga aggtcttact caactcggac   1020
 ttcctatcac acagtggtgc ag                                            1042



      <210> 1747
      <211> 826
      <212> DNA
      <213> Homo sapiens


      <400> 1747
 cgcacacaca atggtgcctg aagaagagcc tcaagaccga gagaaaggac tctggtgggt     60
 ccaggtgaag gtctggtcca tggcagtcgt atccatcttg ctcctcagtg tctgtttcac    120
 tgtgagttct gtggtgcctc acaattttat gtatagcaaa actgtcaaga ggctgtccaa    180
 gttacgagag tatcaacagt atcattcaag cctgacctgc gtcatggaag gaaaggacat    240
 agaagattgg agctgctgcc caaccccttg gacttcattt cagtctagtt gctactttat    300
 ttctactggg atgcaatctt ggactaagag tcaaaagaac tgttctgtga tgggggctga    360
 tctggtggtg atcaacacca gggaagaaca ggatttcatc attcagaatc tgaaaagaaa    420
 ttcttcttat tttctggggc tgtcagatcc agggggtcgg cgacattggc aatgggttga    480
 ccagacacca tacaatgaaa atgtcacgtg agtatagaat gagattctgg cactcaggtg    540
 aacccaataa ccttgatgag cgttgtgcga taataaattt ccgttcttca gaagaatggg    600
 gctggaatga cattcactgt catgtacctc agaagtcaat ttgcaagatg aagaagatct    660
 acatataaat gaaatattct ccctggaaat gtgtttgggt tggcatccac cgttgtagaa    720
 agctaaattg attttttaat ttatgtgtaa gttttgtaca aggaatgccc ctaaaatgtt    780
 tcagcaggct gtcacctatt acacttatga tataatccat ttaaaa                   826



      <210> 1748
      <211> 826
      <212> DNA
      <213> Homo sapiens


      <400> 1748
 cgcacacaca atggtgcctg aagaagagcc tcaagaccga gagaaaggac tctggtgggt     60
 ccaggtgaag gtctggtcca tggcagtcgt atccatcttg ctcctcagtg tctgtttcac    120
 tgtgagttct gtggtgcctc acaattttat gtatagcaaa actgtcaaga ggctgtccaa    180
 gttacgagag tatcaacagt atcattcaag cctgacctgc gtcatggaag gaaaggacat    240
 agaagattgg agctgctgcc caaccccttg gacttcattt cagtctagtt gctactttat    300
 ttctactggg atgcaatctt ggactaagag tcaaaagaac tgttctgtga tgggggctga    360
 tctggtggtg atcaacacca gggaagaaca ggatttcatc attcagaatc tgaaaagaaa    420
 ttcttcttat tttctggggc tgtcagatcc agggggtcgg cgacattggc aatgggttga    480
 ccagacacca tacaatgaaa atgtcacgtg agtatagaat gagattctgg cactcaggtg    540
 aacccaataa ccttgatgag cgttgtgcga taataaattt ccgttcttca gaagaatggg    600
 gctggaatga cattcactgt catgtacctc agaagtcaat ttgcaagatg aagaagatct    660
 acatataaat gaaatattct ccctggaaat gtgtttgggt tggcatccac cgttgtagaa    720
 agctaaattg attttttaat ttatgtgtaa gttttgtaca aggaatgccc ctaaaatgtt    780
 tcagcaggct gtcacctatt acacttatga tataatccat ttaaaa                   826



      <210> 1749
      <211> 2291
      <212> DNA
      <213> Homo sapiens


      <400> 1749
 atgctggtct tgaactcctg ggctcaagtg atccactggc ctcagcctcc caaagtgctg     60
 ggattacagc ctttggaaaa aacccagtac ggcttcctag gaacagatcg tgtagaagag    120
 aaaacttcag tgataaccat cagagttagt gtgacccaca gacacaacag ctacatggaa    180
 gcagaaaacc ttacagaatt atcaaaattt ctcctcctgg gactctcaga tgatcctgaa    240
 ctgcagcccg tcctctttgg gctgttcctg tccatgtacc tggtcacggt gctggggaac    300
 ctgctcatca ttctggccgt cagctctgac tcccacctcc acacccccat gtacttcttc    360
 ctctccaacc tgtcctttgt tgacatctgt ttcatctcca ccacagtccc caagatgcta    420
 gtgagcatcc aggcacggag caaagacatc tcctacatgg ggtgcctcac tcaggtgtat    480
 tttttaatga tgtttgctgg aatggatact ttcctactgg ccgtgatggc ctatgaccgg    540
 tttgtggcca tctgccaccc actgcactac acggtcatca tgaacccctg cctctgtggc    600
 ctcctggttc tggcatcttg gttcatcatt ttctggttct ccctggttca tattctactg    660
 atgaagaggt tgaccttctc cacaggcact gagattccgc atttcttctg tgaaccggct    720
 caggtcctca aggtggcctg ctctaacacc ctcctcaata acattgtctt gtatgtggcc    780
 acggcactgc tgggtgtgtt tcctgtagct gggatcctct tctcctactc tcagattgtc    840
 tcctccttaa tgggaatgtc ctccaccaag ggcaagtaca aagccttttc cacctgtgga    900
 tctcacctct gtgtggtctc cttgttctat ggaacaggac ttggggtcta tctgagttct    960
 gctgtgaccc attcttccca gagcagctcc accgcctcag tgatgtacgc catggtcacc   1020
 cccatgctga accccttcat ctacagcctg aggaacaagg atgtgaaggg ggccctggaa   1080
 agactcctca gcagggccga ctcttgtctc ttacggtgtc cgagctacac agagccacag   1140
 aatctcacag gtgtctcaga attcctcctc ctgggactct cagaggatcc agaactgcag   1200
 ccggtcctcg ctgggctgtt cctgtccatg tacctggtca cggtgctggg gaacctgctc   1260
 atcatcctgg ctgtcagctc tgactcccac ctccacaccc ccatgtactt cttcctctcc   1320
 aacctgtcct tggctgacat cggtttcacc tccaccacgg tccccaagat gattgtggac   1380
 atgcaaactc acagcagagt catctcctat gaaggctgcc tgactcagat gtcttttttt   1440
 gtcctttttg catgtatgga tgacatgctc ctgagtgtga tggcctatga ccggtttgtg   1500
 gccatctgtc accccctgca ctaccgaatc atcatgaacc cacgcctctg tggcttctta   1560
 atcttgttgt ctttttttat tagtcttttg gactcccagt tgcacaattt gattatgtta   1620
 cagctcacct gcttcaagga tgtggacatt tctaatttct tctgtgaccc ttctcaactc   1680
 ctccacctta ggtgttccga caccttcatc aatgaaatgg tcatatattt catgggtgcc   1740
 atatttggct gtctccctat ctcagggatc cttttctctt actataaaat tgtttccccc   1800
 attctgagag ttccaacatc agatgggaag tataaagcct tctccacctg tggctctcac   1860
 ctggcagttg tttgcttatt ttatggaaca gggcttgtag ggtacctcag ttcagctgtg   1920
 ttaccatccc ccaggaagag tatggtggct tcagtgatgt acactgtggt cacccccatg   1980
 ctgaacccct tcatctacag cctgaggaac aaggacattc aaagtgccct gtgcaggctg   2040
 catggcagaa tcatcaaatc tcatcatctc catccttttt gttatatggg atagaaatgg   2100
 cagcaaaatt taacacctag gcctgcaaat tctgcctcct tggtcacatt attttggttg   2160
 cttgatggct ttcattcctc tctgggtttc gtatgtgaat attgcttgct ttgttttgtc   2220
 tttaattgca atgggtgagt attctggtat cctttgttca tcatacacat catgaatgat   2280
 tccaatataa a                                                        2291



      <210> 1750
      <211> 772
      <212> DNA
      <213> Homo sapiens


      <400> 1750
 tttttttttt ttgagctttc agatttgctt ttattggtag ggaaattcca gagtggggag     60
 ccacccagga ggagacaggg gtgccgaggc ttctgggagt ctggaagctc ccggatggag    120
 aggcttacag cccccagcct tccccagcag gagcacaggc aggggactgg ccaagtctgt    180
 cagctcagag caggaccggc ttcagggcct gacttcggtc tcctcttgac ccgccccgga    240
 ggcttgtggg gggcctctgt gtttgcagct ctcctgaaca gagctagatg agggtgggag    300
 gcccccgttg gctcacacag tggatgctac catctccggc ctcttggatg tggagctctg    360
 tgccagagtc aacagtctcc agggtgggcc ccgaagttgt tggtagcgtt ctcaaggccg    420
 aaatctgctt ctccctcaga ttctggtctg tgccgttttc ttctgggata ggctgaataa    480
 gatgattagg atgatcaatg cgagcagcag caccgccatc acagccccca cgatcccata    540
 cacgaggctc ttggcgatgt tgaattcaca ggtctctccc cagtaccagt gtgtgttcgt    600
 atttgggcac aggcagcggg ggccactgcg ttgcagctga catgtgccca ggttacagtt    660
 catttgcgac ttcgttcctt tggtgcactt gttcacacag gccagcttcc catccaagac    720
 atccacatag tagaactggg tatatccttc ggcagccttc tgggtgcatt gc            772



      <210> 1751
      <211> 416
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(416)
      <223> n = a,t,c or g


      <400> 1751
 ccgagcactg ggacttcaac gccaccatct ccaagactcg gtttggggtg aaagatggcg     60
 ctgactgggt acagctggct gctcctcagt gccacattcc tgaatgtggg ggccgagatc    120
 tctatcaccc tggagcctgc ccagccgagc gaaggggaca acgtcacgct ggtcgtccat    180
 gggctttcgg gggaactgct cgcctacagc tggtatgcgg ggcccacact cagcgtgtca    240
 tacctggtgg ccagctacat cgtgagcaca ggcgatgaga ctcctggccc ggcccacacg    300
 gngcgggagg ctgtgcgccc cgatggcagc ctggacatcc agggcatcct gccccggcac    360
 tcaagcacct acatcctgca gaccttcaac aggcagttgc agaccgaggt gggctn        416



      <210> 1752
      <211> 910
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(910)
      <223> n = a,t,c or g


      <400> 1752
 cgaggctaca accccaacgt gaatgcaggc atcattaact cttttgctac tgcagccttt     60
 agatttggcc acacattaat caatcctatt ctttaccgac tgaatgccac cttaggtgaa    120
 atttccgaag gccaccttcc gttccataaa gcgctctttt caccgtccag aataatcaag    180
 gaaggtggga tagacccggt tctccggggg ctgtttggcg tggctgctaa atggcgggca    240
 ccctcctacc ttctcagtcc tgagctgacc cagaggctct tctccgcggc ttattctgcg    300
 gccgtggatt cggctgccac catcattcaa aggggtagag accacgggat cccaccatat    360
 gttgacttca gagttttctg taatttgact tcagttaaga actttgagga tcttcaaaat    420
 gaaattaaag attcagagat tagacaaaaa ctgagaaagt tgtacggctc tccaggtgac    480
 attgacctct ggcccgccct tatggttgaa gacctgattc ctggtacaag agtgggacca    540
 acacttatgt gcatttgtta cccagtttca gcggctaaga gatggagata ggttctggta    600
 tgaaaaccct ggagtattta ccccggcaca actcactcag ctgaagcagg cgtccctgag    660
 ccgggtgctt tgtgacaatg gtgacagcat tcagcaagtg caggctgatg tctttgtaaa    720
 nggcaagaat acccacagga ttacctgaac tgcaagcgag aatccccgaa tgtggaccct    780
 gcgaagtgtn gcaaagactt nctggtgaga actggtaagg agtangagga cagttccaga    840
 gcagtngacg caagaagtct caaaagaaac gctcagcttc aatacagcta tcctgtttga    900
 taaggatatt                                                           910



      <210> 1753
      <211> 910
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(910)
      <223> n = a,t,c or g


      <400> 1753
 cgaggctaca accccaacgt gaatgcaggc atcattaact cttttgctac tgcagccttt     60
 agatttggcc acacattaat caatcctatt ctttaccgac tgaatgccac cttaggtgaa    120
 atttccgaag gccaccttcc gttccataaa gcgctctttt caccgtccag aataatcaag    180
 gaaggtggga tagacccggt tctccggggg ctgtttggcg tggctgctaa atggcgggca    240
 ccctcctacc ttctcagtcc tgagctgacc cagaggctct tctccgcggc ttattctgcg    300
 gccgtggatt cggctgccac catcattcaa aggggtagag accacgggat cccaccatat    360
 gttgacttca gagttttctg taatttgact tcagttaaga actttgagga tcttcaaaat    420
 gaaattaaag attcagagat tagacaaaaa ctgagaaagt tgtacggctc tccaggtgac    480
 attgacctct ggcccgccct tatggttgaa gacctgattc ctggtacaag agtgggacca    540
 acacttatgt gcatttgtta cccagtttca gcggctaaga gatggagata ggttctggta    600
 tgaaaaccct ggagtattta ccccggcaca actcactcag ctgaagcagg cgtccctgag    660
 ccgggtgctt tgtgacaatg gtgacagcat tcagcaagtg caggctgatg tctttgtaaa    720
 nggcaagaat acccacagga ttacctgaac tgcaagcgag aatccccgaa tgtggaccct    780
 gcgaagtgtn gcaaagactt nctggtgaga actggtaagg agtangagga cagttccaga    840
 gcagtngacg caagaagtct caaaagaaac gctcagcttc aatacagcta tcctgtttga    900
 taaggatatt                                                           910



      <210> 1754
      <211> 671
      <212> DNA
      <213> Homo sapiens


      <400> 1754
 aacttcctcc cccgacggct cctgctgaca gggcccccac aggtgggaaa gacgggctcc     60
 tatttacagt tcctcaggat cctcttccgc atgctcatca ggctcctgga ggtggacgtg    120
 tatgatgagg aggagatcaa caccgatcac aatgaaagca gtgaagtgag ccagtcagag    180
 ggagagccct ggcctgacat cgagagcttc agtaaaatgc cttttgatgt cagtgtgcat    240
 gaccccaagt acagtttgat gagcctggtg tatactgaga agctggcagg ggtcaaacaa    300
 gaagtgataa aggaatccaa agttgaagag cccaggaaac gggaaactgt atccataatg    360
 ctgaccaaat atgcagccta taacaccttt caccactgtg aacagtgccg ccagtacatg    420
 gacttcacct ctgcctccca gatgtctgac tccacccttc atgccttcac attctcttct    480
 tctatgctgg gagaagaggt tcagctctat ttcatcattc ccaaatccaa agagagtcat    540
 tttgtcttca gcaagcaggg caagcacctg gagagcatgc ggctgcccct ggtttcagac    600
 aagaatttga atgcagtcaa gagccctatt ttcactcctt ccagtggttg acatgagcac    660
 ggacatgtat t                                                         671



      <210> 1755
      <211> 805
      <212> DNA
      <213> Homo sapiens


      <400> 1755
 gcgagagctt cacaaggaag ttgaagtagc taagaggaat ttggcccaac agaaaattat     60
 atcagaaatg gagtctaagt tagtagaaca acaacttgca gaagaaaaca agcttttaaa    120
 ggagcaagaa aacatgaaag agctagtagt caaccttctc cgcatgactc aaatcaaaat    180
 tgatgaaaag gaacaaaagt ccaaggattt cctgaaagct cagcaaaaat acaccaacat    240
 tgttaaagaa atgaaagcaa aggatcttga aatcaggata cacaagaaga aaaaatgtga    300
 aatttatcgg agactgagag agtttgctaa actgtatgac accattcgaa atgaaagaaa    360
 caaatttgtt aacttactcc acaaagctca tcagaaagta aatgaaataa aagaaaggca    420
 taaaatgtca ttaaatgaac ttgaaattct gagaaatagt gccgttagtc aagaaagaaa    480
 gctacaaaat tccatgctga aacacgccaa caatgttacc atcagagaga gcatgcaaaa    540
 cgatgtgcgc aaaattgtat caaaacttca ggaaatgaaa gaaaagaagg aagcccagtt    600
 aaataacatt gacagacttg ccaacacgat cacaatgatc gaagaggaga tggtgcagct    660
 tcgcaaaaga tacgaaaaag ctgttcagca tcgaaatgaa aggaggggtc tttctcctgg    720
 catgattaca aaggatagat ttttgcctgt ttatggggaa atcacaacca gaaatattca    780
 acttgagaag aaactaatgg gccta                                          805



      <210> 1756
      <211> 1066
      <212> DNA
      <213> Homo sapiens


      <400> 1756
 cggacgcgtg ggaaaaaaag aaagtagtcc ttgaatcctt tctgctacaa agtctgccct     60
 ctggcttctt attctaaggc caaacaggag gagtaactga ttccacccga gagagattca    120
 gagttgcttg gtttcttggc tgttggctgt tgtggtggat gggcctgtgt gtgccttttg    180
 ctgtgactac ctctttcctg tccttaggct tagagtggga cctgaatgtg cggctgcatg    240
 gccagcattt ggtccagcag ctggtcctaa gaacagtgag gggctactta gagacgcccc    300
 agccagaaaa ggcccttgct ctgtcgttcc acggctggtc tggcacaggc aagaacttcg    360
 tggcacggat gctggtggag aacctgtatc gggacgggct gatgagtgac tgtgtcagga    420
 tgttcatcgc cacgttccac tttcctcacc ccaaatatgt ggacctgtac aaggagcagc    480
 tgatgagcca gatccgggag acgcagcagc tctgccacca gaccctgttc atcttcgatg    540
 aagcggagaa gctgcaccca gggctgctgg aggtccttgg gccacactta gaacgccggg    600
 cccctgaggg ccacagggct gagtctccat ggactatctt tctgtttctc agtaatctca    660
 ggggcgatat aatcaatgag gtggtcctaa agttgctcaa ggctggatgg tcccgggaag    720
 aaattacgat ggaacacctg gagccccacc tccaggcgga gattgtggag accatagaca    780
 atggctttgg ccacagccgt cttgtgaagg aaaacctgat tgactacttc atccccttcc    840
 tgcctttgga gtaccgtcac gtgaggctgt gtgcacggga tgccttcctg agccaggagc    900
 tcctgtataa agaagagaca ctggatgaaa tagcccagat gatggtgtat gtccccaagg    960
 aggaacaact cttttcttcc cagggctgca agtctatttc ccagaggatt aactacttcc   1020
 tgtcatgaag gctagaggaa gacttcctgg aactgccttt cttcca                  1066



      <210> 1757
      <211> 933
      <212> DNA
      <213> Homo sapiens


      <400> 1757
 caattaatca agatgctggg tttcatacta atggtacagg acatggtaat ttaaggccaa     60
 gaaagacaag gccattgaag gccgagaatc cttacttgtt tctacgaggt ttgccttacc    120
 tagtaaatga agatgatgta cgtgtctttt tctctggttt gtgcgtggat ggagtaattt    180
 tcttaaaaca tcatgatggc cgaaataatg gtgatgccat agtaaaattt gcttcatgtg    240
 ttgatgcttc aggaggtctt aaatgtcata gaagttttat gggttcaaga tttatagaag    300
 taatgcaagg atcagaacaa cagtggattg agtttggtgg taatgcagtt aaggagggtg    360
 acgttcttag gagatctgaa gaacattctc caccaagagg aattaatgat agacattttc    420
 gaaaacggtc tcattcaaaa tctcccagaa gaacacgttc tcgttcccct cttggatttt    480
 atgttcactt aaaaaatctg tccctcagta ttgacgaaag agatttaaga aatttcttta    540
 gaggtactga tctgactgat gaacagatta ggtttttata taaagatgaa aatagaacaa    600
 gatatgcctt tgtgatgttc aagactctga aagactataa taccgctctg agtttacata    660
 agactgtttt acaatatcgt ccagttcata ttgatccaat ttctagaaaa caaatgctga    720
 agttcattgc acgttatgaa aagaagagat cagggtcact agagagagat aggcccggac    780
 atgtttcaca aaaatactct caagaaggta actctggcca gaaactgtgc atctatataa    840
 gaaattttcc atttgatgtt acaaaagttg aagtgcagaa gttctttgca gactttcttc    900
 ttgctgagga tgtattgcga cgaaatcgtc gac                                 933



      <210> 1758
      <211> 1317
      <212> DNA
      <213> Homo sapiens


      <400> 1758
 ggccctgaag ggatctcttg tccagaatta aacactgatc accagtggac cagagctgcc     60
 tggagcacat cttcactggg ctgcataatg gtttttaaaa aatcctggag cctctatttt    120
 agcatctcga tttgagatat gaagatccat gtttcttgag tttttcttaa acgacagaag    180
 attttgcttc ccagactagc atccctctgt ggctacaacc agcctgaacc gaggggtctg    240
 ccctttagaa gggcccagct cacgggctca ctgtgcactc aggccctagc cagcctgctg    300
 tacgtaggtg tttgcgattt catcattggc cttgttttaa cagacagcag agcagagcac    360
 ctgccataaa gcaagcctcg atgtgctaag tgccatgtgg agcccttgcc ctgctggggc    420
 tcgctgctcc catttgagct gccacagatc agcccctccc cccagggtct ccgaggagtc    480
 aggaccgcac agcctgccct cctagggaag gacttcctca gggaaggcag gcatgtggaa    540
 gccaggtgca gagtcctggc ctctccacac aggtgccgcc caggtgatgt ggtttgagaa    600
 gctgtatgct ggcctgcagt gcgtagagaa gtacctcatc taccccgccg tggtgctcaa    660
 cgccctcacg gtggacgccc acacagtcgt cagccacccg gacaagtact gcttctactg    720
 ccgggcgctg ctgatgaccg tggctgggct gaagctgctg cgctcagcct tctgctgccc    780
 cccacagcag tacctgacgt tggccttcac cgtcctgctc ttccactttg actacccgcg    840
 cctctcccag ggctttctgc ttgactactt cctcatgtcc ctgctttgca gcaagctgtg    900
 ggacttgctg tacaagctgc gtttcgtgct gacctacatc gcgccctggc agatcacctg    960
 gggctcggct ttccacgctt ttgcccagcc gtttgccgtg ccacactcgg ccatgctgtt   1020
 cgtccaggcc ctgctctcgg ggctcttctc cacgcctctc aacccactgc taggcagtgc   1080
 cgtcttcatc atgtcctacg ctcggcccct caagttctgg gagcgcgact acaacactaa   1140
 acgtgtggat cattccaaca cccgcctggt cacacagctg gacaggaacc ctggcgctga   1200
 tgacaacaac ctcaactcca tcttctatga gcacttgaca cgttcgctgc agcacacact   1260
 gtgtggggac ctggtgctgg gccgctgggg caactatggc cctggtgact gcttcgt      1317



      <210> 1759
      <211> 1317
      <212> DNA
      <213> Homo sapiens


      <400> 1759
 ggccctgaag ggatctcttg tccagaatta aacactgatc accagtggac cagagctgcc     60
 tggagcacat cttcactggg ctgcataatg gtttttaaaa aatcctggag cctctatttt    120
 agcatctcga tttgagatat gaagatccat gtttcttgag tttttcttaa acgacagaag    180
 attttgcttc ccagactagc atccctctgt ggctacaacc agcctgaacc gaggggtctg    240
 ccctttagaa gggcccagct cacgggctca ctgtgcactc aggccctagc cagcctgctg    300
 tacgtaggtg tttgcgattt catcattggc cttgttttaa cagacagcag agcagagcac    360
 ctgccataaa gcaagcctcg atgtgctaag tgccatgtgg agcccttgcc ctgctggggc    420
 tcgctgctcc catttgagct gccacagatc agcccctccc cccagggtct ccgaggagtc    480
 aggaccgcac agcctgccct cctagggaag gacttcctca gggaaggcag gcatgtggaa    540
 gccaggtgca gagtcctggc ctctccacac aggtgccgcc caggtgatgt ggtttgagaa    600
 gctgtatgct ggcctgcagt gcgtagagaa gtacctcatc taccccgccg tggtgctcaa    660
 cgccctcacg gtggacgccc acacagtcgt cagccacccg gacaagtact gcttctactg    720
 ccgggcgctg ctgatgaccg tggctgggct gaagctgctg cgctcagcct tctgctgccc    780
 cccacagcag tacctgacgt tggccttcac cgtcctgctc ttccactttg actacccgcg    840
 cctctcccag ggctttctgc ttgactactt cctcatgtcc ctgctttgca gcaagctgtg    900
 ggacttgctg tacaagctgc gtttcgtgct gacctacatc gcgccctggc agatcacctg    960
 gggctcggct ttccacgctt ttgcccagcc gtttgccgtg ccacactcgg ccatgctgtt   1020
 cgtccaggcc ctgctctcgg ggctcttctc cacgcctctc aacccactgc taggcagtgc   1080
 cgtcttcatc atgtcctacg ctcggcccct caagttctgg gagcgcgact acaacactaa   1140
 acgtgtggat cattccaaca cccgcctggt cacacagctg gacaggaacc ctggcgctga   1200
 tgacaacaac ctcaactcca tcttctatga gcacttgaca cgttcgctgc agcacacact   1260
 gtgtggggac ctggtgctgg gccgctgggg caactatggc cctggtgact gcttcgt      1317



      <210> 1760
      <211> 859
      <212> DNA
      <213> Homo sapiens


      <400> 1760
 caagcactgc cacctgggct ggagtgcagt ggtgcaatct cagctcactg caacctctgc     60
 cttccgggtt caagccattc tcctgcctca gcctcccagg tagctgggat cacaggcacc    120
 tgccaccatg cccagctaac tttttgtatt gttttttttt agtagagatg gggtttcact    180
 atgttggcca ggctggtctc aaactcctga cctcgtgatc tgtgcgcctc ggccccccaa    240
 agtgctggga gtacaggcgt gaaccaccgc gtccggctgg ggctgcttat ttacatcccc    300
 tagaaagagg gattctccag ctacacctca ccctcacttg gaaggaccct cctcccagag    360
 agggagctgt ggaaaaagcc tgacctgccc cacagggcag taggtcgagc ctggctggtg    420
 agcaaggagg tacggggatc cctgaggcct cccacccagg gcccagggag cctgcctgct    480
 gtgagcactt cctccagtcc tgatggactc ggctctgccc ggagcccccg gtctctgcac    540
 acacagctga ctggagaaag ccacttccat ctcatggaca gggacagaac aaggctgagg    600
 gaggtgagca atgcagccag gcccgggggc tacaatggct gctggcaaaa cccaccatct    660
 cagcaatagt tcagcgcgaa gggctgagaa ctgtgagaag cgaatcgcga cgtttatttt    720
 gctcttcctt agcctcttgt ggcagatttg gggcaaaaca acagattaaa tcttgtgtac    780
 atatatttac atgtggatag acacactgca gaagaggtct ctgttttgta aactctaacg    840
 acagataact gcgaattcc                                                 859



      <210> 1761
      <211> 1846
      <212> DNA
      <213> Homo sapiens


      <400> 1761
 acaggaagcc ccttccgccc tctgggcctc agtttcccca caccggggct ggtctgctcc     60
 tagctctggg tgcaggacac acaggagtgg cacaggtcgg gctggggaga gccttctctc    120
 ctttgtggtc caggatggcg cagaagtacc atgagtactc ccactacaag gagcaggatg    180
 ggcaggggat gaagcagcgg cctccgcggg gctcccacgc gccctatctc ctggtcttcc    240
 aagccatctt ctacagcttc ttccatctga gcttcgcctg cgcccagctg cccatgattt    300
 atttcctgaa ccactacctg tatgacctga accacacgct gtacaatgtg cagagctgcg    360
 gcaccaacag ccacgggatc ctcagcggct tcaacaagac ggttctgcgg acgctcccgc    420
 ggagcggaaa cctcattgtg gtggagagcg tgctcatggc agtggccttc ctggccatgc    480
 tgctggtgct gggtttgtgc ggagccgctt accggcccac ggaggagatc gatctgcgca    540
 gcgtgggctg gggcaacatc ttccagctgc ccttcaagca cgtgcgtgac taccgcctgc    600
 gccacctcgt gcctttcttt atctacagcg gcttcgaggt gctctttgcc tgcactggta    660
 tcgccttggg ctatggcgtg tgctcggtgg ggctggagcg gctggcttac ctcctcgtgg    720
 gcttacagcc tgggcgcctc agccgcctca ctcctggggc ctgctgggcc tgtggctgcc    780
 acgccccgtg cccctggtgg ccggagcagg ggtgcacctg ctgctcacct tcatcctctt    840
 tttcttgggc ccctgtgcct cgggtcctgc aacacagctg gatcctctat gtggcagctg    900
 ccctttgggg tgtgggcagt gccctgaaca agactggact cagcacactc ctgggaatct    960
 tgtacgaaga caaggagaga caggacttca tcttcaccat ctaccactgg tggcaggctg   1020
 tggccatctt caccgtgtac ctgggctcga gcctgcacat gaaggctaag ctggaaggtg   1080
 ctgctggtga cgctggtggc ggccgcggtc tcctacctgc ggatggagca gaagctgcgc   1140
 cggggcgtgg ccccgcgcca gccccgcaat cccgcggccc cagcacaagg tgcgcggctt   1200
 accgctactt gcaggcgcac aactcggacg agagcgaccc ggagggcgag catgcggacg   1260
 ccgcgcagga ggaggcgccg cccgcagggc ccaggcctgg gccccgagcc cgctggactc   1320
 ggccgccggc cgtgcccgta cgaacaggcg caggggggag accggcccgg aggagcagtg   1380
 aaggggccgc ctggtccccg ggactcagcc tcccttcttc gccggcctca gtttaccacc   1440
 gtctgagggt cgggggggac ccccctccga ggtcccgcgc ttgtcttcaa aggccccttg   1500
 tctccccttc cccgacgttg gggacgcccc ttcccagagc ccaggtcacc ttccggggtt   1560
 ccgcagcccc cttccaaggg cggagtggag ccttgggaac ccctcggcca agcacagggg   1620
 ttcgaaaata cagctgaaac cccgcgggcc cttagcacgc gccccagcgc cggagcacgg   1680
 tcagggtctt cttgcgaccc ggcccgctcc agatccccac agctctcggc cgcggacccg   1740
 ggccgcgtgt gagcgcactt tgcacctcct atccccaggg tccgccgaga gccacgattt   1800
 tttacagaaa atgagcaata aagagatttt gtactgtcaa aaaaaa                  1846



      <210> 1762
      <211> 1699
      <212> DNA
      <213> Homo sapiens


      <400> 1762
 gctgcgggcc ggtgaagata tggcggcgtc tgcgtctgca gctgcagggg aggaggactg     60
 ggtccttccc tctgaagttg aagtattgga gtccatctat ctagatgaac tacaggtgat    120
 taaaggaaat ggcagaactt caccatggga gatctacatc actttgcatc ctgccactgc    180
 agaggaccag gattcacagt atgtctgctt cactctggtg cttcaggtcc cagcagagta    240
 tccccatgag gtgccacaga tctctatccg aaatccccga ggactttcag atgaacagat    300
 ccacacgatc ttacaggtgc tgggccacgt ggccaaggct gggctgggca ctgccatgct    360
 gtatgaactc attgagaaag ggaaggaaat tctcacagat aacaacatcc ctcatggcca    420
 gtgtgtcatc tgcctctatg gtttccagga gaaggaggcc tttaccaaaa caccctgtta    480
 ccactacttc cactgccact gccttgctcg gtacatccag cacatggagc aagagctgaa    540
 ggcacaagga caggagcagg aacaggaacg gcagcatgct acaaccaaac agaaggcagt    600
 cggtgtgcag tgtccagtgt gcagagagcc cctcgtgtat gatcttgcct cactgaaagc    660
 agcccctgaa ccccaacagc ccatggagct gtaccagccc agtgcagaga gcttgcgcca    720
 gcaagaagaa cgcaagcggc tctaccagag gcagcaggag cgggggggaa tcattgacct    780
 tgaggctgag cgaaaccgat acttcatcag ccttcagcag cctcctgccc ctgcggaacc    840
 tgagtcagct gtagatgtct ccaaaggatc ccaaccaccc agcacccttg cagcagaact    900
 atccacctca ccagccgtcc aatccacttt gccacctcct ctgcctgtgg cgacccagca    960
 catatgtgag aagattccag ggaccaggtc aaatcagcaa aggttgggcg aaacccagaa   1020
 agctatgcta gatcccccca agcccagtcg aggtccctgg cgacagcccg aacggaggca   1080
 cccaaaggga ggggagtgcc acgcccctaa aggtacccgt gacacccagg aactgccacc   1140
 tcctgagggg cccctcaagg agcccatgga cctaaagcca gaaccccata gccaaggagt   1200
 tgaaggtcct ccacaagaga aggggcctgg cagctggcag gggcccccac cccgcaggac   1260
 tcgggactgt gttcgctggg agcgctctaa aggccggaca cccggttctt cctaccctcg   1320
 cctgcctcgg ggccagggag cataccggcc tggtactcgg agggagtccc tgggcctgga   1380
 atctaaggat ggttcctagc aggacttggt ggggggaaca gggaattggg gatgggaggg   1440
 aggcaataaa gatatttggc cttctttggc tttctttgct tagcagcgcc tagcctgtga   1500
 ggaatggctc tttttctcaa ttcctaataa gattggggtg tggcagagca gcccccaact   1560
 ttgctctgaa gtctgttctc cgaagagctg ggtaaagagg gtctgacatc tcatcagcta   1620
 gtatagtgag tttcagggaa aactattggg atgtctgcat gtaagcagag tccttaggac   1680
 ccaccgttaa caactcatt                                                1699



      <210> 1763
      <211> 1855
      <212> DNA
      <213> Homo sapiens


      <400> 1763
 gggcaaagat aaatagagtc acaaaaaaca gaacattgat ggccacaaca gcaacctggt     60
 caatatttcc ttggggaacc tgagcttcat ctgtacttgc ttcttcaaaa ttaatacttt    120
 tacactgtct tcctgagtca tccacacgat gttctcttag tatggcaagg atcagaataa    180
 tatttaaaat tcccaggaag gcgctaagta aaactggtgt tgtatacatg tttatctgca    240
 gtttaatcac atcccatgtc acaccttttt ctccaaggaa tgtaaaacaa gtctgaaaaa    300
 ctgctccaat tcccaacaat ccacgagcaa ccagcatgta gtatttatta tgagaagctg    360
 ggatgtggag atatgcatag aggcagttgg ctgccacgga aatcaagatg gagacaataa    420
 gaggctcttt tcttggtcta taattagacc ataaaccaaa tataggtgaa gctaccattt    480
 ggccaagact atatgaagca ataacccagc ccaaaaaact tgtatcagct gtcggatcaa    540
 tcttttggag atatggccat atggacatca tcactacaga aaaccctaca ctgctgagaa    600
 acatagtaag atataaaatc ctaatagatc tccatcggct cttataatgc tcttcagtct    660
 ctaaaatgtc ccattctctg cttccaggtg tgtcgcctaa gagcggctcc tgttcacttt    720
 cgttccgcag gccggccata gttacactcc ctacaaggcg tcttgcgccc aactctcgcg    780
 acacctgctt tctcccatcc cgggtggcgt gaagctggca aaacaagcct gtaagtgcgc    840
 gtgcgcacct gacggtcaga cgtaggcgga acgccccgag gtcataggcg gggtcacgcg    900
 gaaggccggg cagcgcaggg cgaaaggagg ctgtgtcctc agcctcctcc ctcggcacgc    960
 gcctcccatc ctgacgggga ctgagagccc aggagagctc ggggcgtgtc caaactgccg   1020
 cgccgccctg ctccgggttt gtcttcctcc ctccgtttct ccttccgctg tatctagcat   1080
 ttcggttcct ggaaaggtta ccggagctgc gattggggct gggaccaaag ttgagtcctg   1140
 gaaagggagc ctggagagcg gcggtgctgg gaggcccggc cagctcgatc gcaggcttcc   1200
 acctggcggc caatgcttgt ttgctactga tgggtgtgag caagttagat attctatacc   1260
 ggagacttct cctaacaaaa ctttttatca gaggatgggg aaggccagaa gatctcaaaa   1320
 gactctttga attcagaaag atgattggaa atcgggaaag atgccagaat ctggtttcaa   1380
 gcgattatcc agtacacatt gataagattg aagagcaatc agattgtaag atcttagatg   1440
 gacactttgt ttcccccatg gctcactatg tgcctgatat catgccaatt gaatctgtta   1500
 ttgcaaggtt ccaatttatt gtgcctaaag aatggaacag caaatataga cctgtatgca   1560
 ttcatcttgc tggaacagga gatcatcatt actggaggcg acgaacacta atggcccgtc   1620
 ctatgattaa agaagcccga atggcttctt tattgttaga aaacccttat tgatgacgtc   1680
 agactattca cagaagaaga aatgaaactg gtgcacagat ataaagaaat gttcaacgtt   1740
 gctggtaata aatgtagagt taaaacaaca atgatcaaat atttaaaaaa aaacagtact   1800
 ggtgaggctg ctttgaaatg ggcactcttg ttactaatga ctgaaaatta gttca        1855



      <210> 1764
      <211> 1026
      <212> DNA
      <213> Homo sapiens


      <400> 1764
 gaaactgcaa gagtggggca gagaaccaga gtgtcagagc aaaacctcct ctatctgcac     60
 atcctgggga cgaaccgggc agccggagag ctgcggccgg cccagtcccg ctccgccttt    120
 gaagggtaaa acccaaggcg gggccttggt tctggcagaa gggacgctat gaccgcagaa    180
 ttcctctccc tgctttgcct cgggctgtgt ctgggctacg aagatgagaa aaagaatgag    240
 aaaccgccca agccctccct ccacgcctgg cccagctcgg tggttgaagc cgagagcaat    300
 gtgaccctga agtgtcaggc tcattcccag aatgtgacat ttgtgctgcg caaggtgaac    360
 gactctgggt acaagcagga acagagctcg gcagaaaacg aagctgaatt ccccttcacg    420
 gacctgaagc ctaaggatgc tgggaggtac ttttgtgcct acaagacaac agcctcccat    480
 gagtggtcag aaagcagtga acacttgcag ctggtggtca cagataaaca cgatgaactt    540
 gaagctccct caatgaaaac agacaccaga accatctttg tcgccatctt cagctgcatc    600
 tccatccttc tcctcttcct ctcagtcttc atcatctaca gatgcagcca gcacagttca    660
 tcatctgagg aatccaccaa gagaaccagc cattccaaac ttccggagca ggaggctgcc    720
 gaggcagatt tatccaatat ggaaagggta tctctctcga cggcagaccc ccaaggagtg    780
 acctatgctg agctaagcac cagcgccctg tctgaggcag cttcagacac cacccaggag    840
 cccccaggat ctcatgaata tgcggcactg aaagtgtagc aagaagacag ccctggccac    900
 taaaagaggg gggatcgtgc tggccaaggt tatcggaaat ctggagatgc agatactgtg    960
 tttccttgct cttcgtccat atcaataaaa ttaagtttct cgtcttaaaa agaaaaaaaa   1020
 aaaaaa                                                              1026



      <210> 1765
      <211> 1026
      <212> DNA
      <213> Homo sapiens


      <400> 1765
 gaaactgcaa gagtggggca gagaaccaga gtgtcagagc aaaacctcct ctatctgcac     60
 atcctgggga cgaaccgggc agccggagag ctgcggccgg cccagtcccg ctccgccttt    120
 gaagggtaaa acccaaggcg gggccttggt tctggcagaa gggacgctat gaccgcagaa    180
 ttcctctccc tgctttgcct cgggctgtgt ctgggctacg aagatgagaa aaagaatgag    240
 aaaccgccca agccctccct ccacgcctgg cccagctcgg tggttgaagc cgagagcaat    300
 gtgaccctga agtgtcaggc tcattcccag aatgtgacat ttgtgctgcg caaggtgaac    360
 gactctgggt acaagcagga acagagctcg gcagaaaacg aagctgaatt ccccttcacg    420
 gacctgaagc ctaaggatgc tgggaggtac ttttgtgcct acaagacaac agcctcccat    480
 gagtggtcag aaagcagtga acacttgcag ctggtggtca cagataaaca cgatgaactt    540
 gaagctccct caatgaaaac agacaccaga accatctttg tcgccatctt cagctgcatc    600
 tccatccttc tcctcttcct ctcagtcttc atcatctaca gatgcagcca gcacagttca    660
 tcatctgagg aatccaccaa gagaaccagc cattccaaac ttccggagca ggaggctgcc    720
 gaggcagatt tatccaatat ggaaagggta tctctctcga cggcagaccc ccaaggagtg    780
 acctatgctg agctaagcac cagcgccctg tctgaggcag cttcagacac cacccaggag    840
 cccccaggat ctcatgaata tgcggcactg aaagtgtagc aagaagacag ccctggccac    900
 taaaagaggg gggatcgtgc tggccaaggt tatcggaaat ctggagatgc agatactgtg    960
 tttccttgct cttcgtccat atcaataaaa ttaagtttct cgtcttaaaa agaaaaaaaa   1020
 aaaaaa                                                              1026



      <210> 1766
      <211> 369
      <212> DNA
      <213> Homo sapiens


      <400> 1766
 caaacatggc gtgttcctag aagccgcttt cggcatcagt aggcggcggc gtggggtctg     60
 gcagcgtggg gagagggacc aaccgacgcc acttcgtgtt gggaagtggg agcgggaggg    120
 ccgggcaatt cccgaccgaa ccaaacggtt tccatggatc tcaatagtgc cagcactgtt    180
 gttcttcagg tgttaacaca ggccaccagt caggatactg ctgtgttaaa accagctgag    240
 gagcagttga agcagtggga gacacagcca ggtttctatt cagtgttgct gaatattttc    300
 accaaccaca ctttggatat aaatgtaagg tggcttgctg tactgtattt taaacatgga    360
 attgatcgt                                                            369



      <210> 1767
      <211> 4879
      <212> DNA
      <213> Homo sapiens


      <400> 1767
 agcggccgcg acagggccag cgagagcccc gcagctctgc cgcagctgcc gcctcgccgc     60
 ggccgggccg gagtagcact gttgcgggag cgcggcctta cgaggcggcc ggagcggtgg    120
 gcacagctcg gcgcggagcg tcctgtcagg cggcggccga gggcgtcgcg gactctcccc    180
 gcgatgatgc cgatgatatt aactgttttc ttgagcaaca atgaacagat tttaacagaa    240
 gttcctataa caccggaaac aacctgtcga gatgttgtag aattttgcat ggaacctgga    300
 gaaggcagct gccatttaac tgaagtgtgg aggggaaatg aacgtcccat accctttgat    360
 catatgatgt acgaacatct tcagaaatgg ggtccacgga gggaagaagt gaaatttttt    420
 cttcgacacg aggactcccc aactgagaac agtgaacaag gtggccgtca gacccaagag    480
 caacgaactc agagaaatgt aataaatgta cctggagaaa aacgtactga aaatggggtt    540
 gggaatccac gtgttgaact taccctctca gagctccaag atatggcagc taggcaacag    600
 cagcagattg aaaatcagca gcagatgttg gttgccaagg aacagcgttt acattttcta    660
 aagcaacagg agcgccgtca gcagcagtct atttctgaaa atgaaaagct tcagaaattg    720
 aaagaacgag ttgaagccca ggagaacaag ctgaagaaaa ttcgtgcaat gagaggacaa    780
 gtcgactaca gcaaaatcat gaacggcaat ctgtctgctg aaatagaaag gttcagtgcc    840
 atgttccagg aaaagaagca ggaagtacag actgcaattt taagggttga tcagcttagt    900
 cagcaattgg aagatttaaa gaaaggaaaa ctgaatgggt tccagtctta caatggcaaa    960
 ttgacgggac cagcggcggt ggagttaaaa agactgtacc aagaactaca gattcgtaac   1020
 caacttaacc aggaacaaaa ttcaaaactt cagcagcaga aggaactctt aaataagcgc   1080
 aacatggagg tggccatgat ggacaagcga atcagtgaac tgcgtgaacg tctctatggg   1140
 aaaaaaattc agctgaaccg tgtgaatggc acgtcatcac cacagtcccc tctgagcaca   1200
 tcgggcaggg tcgctgctgt ggggccttat atccaggttc ccagtgccgg aagctttcct   1260
 gtgctggggg accctataaa gccccagtct ctcagtattg cctcaaatgc tgctcatgga   1320
 agatccaaat ccgctaatga tggaaactgg ccaacattaa aacagaattc tagctcttcc   1380
 gtgaaaccag tgcaggtggc cggtgcagac tggaaggatc cgagcgtgga ggggtctgtc   1440
 aagcagggca ctgtctccag ccagcctgtg cccttctcag cactgggacc cacggagaag   1500
 ccgggcatcg agattggtaa agtgccacct cccatcccgg gtgtaggcaa gcagctgcct   1560
 ccaagctatg ggacataccc aagtcctaca cctctgggtc ctgggtcgac aagctccctg   1620
 gaaaggagga aggaaggcag cttgcccagg cccagtgcag gcctgccaag tcgacagagg   1680
 cccaccctgc tgcccgccac aggcagcacc ccccagccag gctcctcaca acagattcag   1740
 cagaggattt ccgtaccgcc aagtcccacg tacccgccag cgggaccacc tgcatttcca   1800
 gctggggaca gcaagcctga actcccactg acagtggcca ttaggccttt cctggctgat   1860
 aaagggtcaa ggccacagtc tcccaggaaa ggaccccaga cagtgaattc aagttccata   1920
 tactccatgt acctccagca agccacacca cctaagaatt accagccggc agcacacagc   1980
 gccttaaata agtcagttaa agcagtgtat ggtaagcccg ttttaccttc gggttcaacc   2040
 tctccatcgc cgctgccgtt tcttcacggg tcactgtcca cgggcacacc acagccttca   2100
 gccacctttc agaaagtact gagaaagagc ctttagcagg atggccccgc cgaccccgca   2160
 gatggcagca ccgtggagag cctgccacgg ccactcagcc ccaccaagct cacgcccatc   2220
 gtgcattcgc cactgcgcta ccagagtgat gcagacctgg aggccctccg caggaagctg   2280
 gccaacgcgc cccggcccct gaaaaagcgc agctccatca cagagcccga gggccccggc   2340
 gggcccaaca tccagaagct gctgtaccag cgcttcaaca ccctggccgg tggcatggag   2400
 ggcacccctt tctaccagcc cagcccctcc caggacttca tggtcacctt ggccgatgtg   2460
 gacaatggaa acaccaatgc caatggaaac ctggaagagc tcccccctgc ccagcccaca   2520
 gccccactcc ccgctgagcc tgccccgtca tcagatgcca atgataatga gttaccttcc   2580
 cccgaaccag aggagctcat ctgtccccaa accacccacc aaactgccga gccggcagag   2640
 gacaataaca acaacgtggc cacggtcccc accacggagc agatcccgag tcctgtggct   2700
 gaggccccat ctccagggga agagcaggtc cctccagcac ctcttccccc tgccagccac   2760
 cctcctgcca cctccacgaa caagcggacc aacttgaaga agcccaactc ggagcggacg   2820
 gggcacgggc tgagagtccg gtttaacccc ctggcactgc tcctagacgc gtctctggaa   2880
 ggagagttcg atctggtgca gaggatcatc tatgaggtgg aagatcccag caagcccaac   2940
 gacgaaggga tcaccccact gcacaacgcc gtctgcgccg gccaccatca catcgtgaag   3000
 ttcctgctgg attttggtgt caacgtgaat gctgctgata gtgatggatg gacgccgctg   3060
 cactgcgctg cctcttgtaa cagcgttcac ctctgcaaac agctggtgga gagtggtgcc   3120
 gccatttttg cctcaaccat aagcgacatt gaaactgctg cagacaagtg tgaggagatg   3180
 gaggaaggct acatccagtg ctcccagttt ctatatgggg tgcaggaaaa gctgggtgtg   3240
 atgaacaaag gtgtggcgta tgctctgtgg gactacgagg cccagaacag tgacgagctg   3300
 tccttccacg aaggggacgc cctcaccatc ctgaggcgca aggacgaaaa gcgagactga   3360
 ggtggtggtg ggctcgcctt ggagaccggg agggctatgt gcccaaaaac ctgctggggc   3420
 tgtatccacg gattcaaacc cccgacagcg aacactcgcc tgaacttcct tttggagcac   3480
 cgcatggtct tgccagctac caggagccac ttaagagatt attgtgctgt tttccaggaa   3540
 agctgcagct agaaaatggt cttaatggtg ctcactttag cagacagcgt ccacaatgtg   3600
 aatcctacag tttccaggtg aggccctttc tccagtttgc ccattaactg ggagaggtac   3660
 tttcgcctcc aaggactgaa ttttgccaat tactataaat ccaaataaat acccactttc   3720
 aaaacaccca cccctcttgc cattaagaag tcccataacc cccggttggt tgccagtgaa   3780
 gacagaagct cttactgact tggccccgag gcattcaccc cctccagcag tgaacactgt   3840
 ccgccgctgt gaggcctgct cccctgcgac cgctctgccc cccgtcaccg aatcggacac   3900
 tcatcctttc tcacacttcc cacacatgat ccttcttccc ttcatcacca aaggaggcct   3960
 ctgtatggga aacatgttcc agtgttggtg gcccagtgtg tatgcctccc agtacccact   4020
 ctgctcggcc gccttggggg ttccgcttcc tgttccagtt cacctaaagg ctgattgtgc   4080
 aggcccagca ctgtggctgg actgccgcgc cacgggcacc aggaccccta agaccaagtg   4140
 acaactggga gagcctcagc atatactctt ctcctccgat ctcacagcct gtcatgctgc   4200
 tcagtgtggt tctcacccct gcaagctcaa attcagttcc ctgaatggag tcaggtgctg   4260
 gaggccgtgg cagcggaggg tggttggggt tggggctggg ggtggactgg tgtgagggca   4320
 gaccagggcc aggtagacgg ggctgtttgg tgcctgaagg atggcagacg cctggtgtca   4380
 ggaggggccg ccaccaagga gcagcagctg gggcagagga gctggggtca ggggccaccc   4440
 ctctctgccg atctccctgc ctgggctggc tgtgaggccc acctttgtcc caggcccagc   4500
 ctcaaggcaa ggagggcgct tcactgaggt gtgaattgta cgtacaggct ttttatatac   4560
 caaaagtatt ttttgactag accattcaaa gctacccgaa ctatgttgga aatttttttt   4620
 ttctcattaa aatacaggcc cttaggctct atttttcatg tatgagtcgt gtgtaattta   4680
 tgtaaaaatg tgtgtacaga ctcactgatg cagcactgta gcccatcacc ttggagcact   4740
 gactgtacat agtgtggtga agaaaagtga acgcccttgt agagcagccc gaccacagga   4800
 gcatggccgc tgccagccca gacgctgctg acgctgtgta aatgtgcaca ataaacccgt   4860
 ctcaccccga aaaaaaaaa                                                4879



      <210> 1768
      <211> 442
      <212> DNA
      <213> Homo sapiens


      <400> 1768
 agtggggccg cctctgaaaa aaaatgtgag agcagtcact catgaaatgt tgtttaaggg     60
 gaaccttctg gatccttttc atggcaccat ggcaagaaga agctgtatct tatctatgga    120
 agataaagca tggagttggc taatggatgc tgaactaaat ctccataccc acttcatccg    180
 tgtttttggc ttatgtatgg gatgctagaa tggcctatct ccatgtattt tgttgcattt    240
 ctccattgct tcttgtgttc tggcgggaat cttggtgatt cttttcaagc actacctgag    300
 ctctgtgcca attgttcctc ttctcccagg gtgttgtgct gcgtggtcat gtctccactt    360
 ccttagccct gtccattgac agaaccttgg gttctgtgat ggctgcctct aaacccttgt    420
 gaaagcgggg aatattcctc cc                                             442



      <210> 1769
      <211> 1402
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1402)
      <223> n = a,t,c or g


      <400> 1769
 tttcgagagc ttttctgcat atttttgaaa aacatagtac atcagtgtgt agaaaaaaat     60
 tatttgaact aaatcagttt gttgacaatg gtgtatttat atacaatgac taaatcagtg    120
 gtgtatttat gtgtaatact agaaactgca catgtcaaca accccactac aacctgataa    180
 taaatatctt acatgatgtg acagttaacg taaagggttg tcttaccaaa gtaacgaaat    240
 gtttaatggg aacatatttt aaaatgcatc aatacttaaa ataattaatt gtagtagtca    300
 tagtatgtca gcttttaata atcttgggag tggctactat attgtacggc gcaggtctta    360
 ttgtcatttt ctcgactttg gcccaaattg ataaagaagg tgtgattgaa ccagacactg    420
 atgctcctca agaaatggga gatgaaaatg cggaggtaag ttcggggact tgatttcctg    480
 cttgttctaa gaaatgtgaa aggtcctgct gttgcaatga ttttatgaca cgattcttcc    540
 aggaaaagcg catagtaaat ctttctctga cttcaggcgt tttaggcaag cattgtattt    600
 tactacttaa aatactaatg aaaataaata ctgttacttt ctgttttatc tgttttttaa    660
 gtttgcatct ggtgtgactg cttgcactgt aacgcanaat tcacttaaaa tacataccta    720
 ttagtggagt tgctcttgat ggaatatcta atgccaaatt gtattacaga atggtttgtc    780
 ataacaggcc ctcaagggag tgaaaattgg ttcttgggag gagggcttaa aaaaaattct    840
 atatattaca atggttagtg gtcctccaaa gactcataga atattaatat gtagtgtatc    900
 tgtggtatta aaattgggga tatggaaatg aggaaaagat gtctaaaaag gctccttagt    960
 gtctgataaa aatttgagaa acactctaat atagtaatag cagttttaaa agattggttt   1020
 ttatcctcaa aacttgatat tatcagattt catctttgcc aagtattgtg ggaaatggta   1080
 tctttttgtg gcttttaatt tgcattttcc tggccaaaca gggggggtcc cgcctgtaat   1140
 tccagccctt tgggaggccg aggggggggg gtcatttaag gtccggagtt ttaggccagc   1200
 ctggccaaca tggggaaacc cccttttttt ttataattca aaaataagcc cggccttatg   1260
 gggcccgccc gtaatcccgt ctgctttggg gggtgaggcg ggaaaatccc tttagccccg   1320
 gaggcaaagg ttccaaagag gtgggattgc ccccctgccc tccagggtga ggggcagagc   1380
 aaaacttttt ttaaaaaaaa aa                                            1402



      <210> 1770
      <211> 891
      <212> DNA
      <213> Homo sapiens


      <400> 1770
 tttcgtgaaa aaaggaagat ggcaagaata ttgttacttt tcctcccggg tcttgtggct     60
 gtatgtgctg tgcatggaat atttatggac cgtctagctt ccaagaagct ctgtgcagat    120
 gatgagtgtg tctatactat ttctctggct agtgctcaag aagattataa tgccccggac    180
 tgtagattca ttaacgttaa aaaagggcag cagatctatg tgtactcaaa gctggtaaaa    240
 gaaaatggag ctggagaatt ttgggctggc agtgtttatg gtgatggcca ggacgagatg    300
 ggagtcgtgg gttatttccc caggaacttg gtcaaggaac agcgtgtgta ccaggaagct    360
 accaaggaag ttcccaccac ggatattgac ttcttctgcg agtaataaat tagttaaaac    420
 tgcaaataga aagaaaacac caaaaataaa gaaaagagca aaagtggcca aaaaatgcat    480
 gtctgtaatt ttggactgaa cgttttaaga aatttgttac cttacagaag agcaagggct    540
 taggggttgg aggtggcaga taaaagagga ttttcaactc aaatcttgtt tcctgctggc    600
 ctggtctgcc cacgagctag agcggggaaa tgttgagctc aaatgggtaa attgagacca    660
 gaaaattatt ttttcaacct agagaatctc ctcttacagg gggatgcata taacagatca    720
 tgtatgtgta gttatttcta aagtagtaat tctttcccca gctctttgat ttgccatata    780
 taaatagggg ggggtcggta tgtcttccct ttagacatga tgttttctac tcgatttgtc    840
 tctctggcca attgaattat taataaaagg tctgtattat caaaaaaaaa a             891



      <210> 1771
      <211> 1215
      <212> DNA
      <213> Homo sapiens


      <400> 1771
 gccctttata ttttttttaa aaattcaaaa aattagttta ttagcttaat ataattaggt     60
 ccaatggaat cctgttttga tctcaatact tcccatattg caatatataa atgtgacaaa    120
 ttcagctgtt ttgtggcata gataagtgtc taagctgggc agttagtcta ccccgtttca    180
 tagttcatgt tcttcatggc tttgcagcat ttgtcacttt ctatgatgtg ttcaaagacc    240
 agaaaaggcc acacttgacc tgtcagctgg tccttgaaca gctgtaggtt tttttttttt    300
 tttttgagac cagagtctcc cttctgttgt ccagctggga gtgggcagta gcgcaacctc    360
 gactcactgg caacctctgg cctccaggtt caagtgattc tcctcctcca gactcctgga    420
 gtagctgggg attacaggca catggccacc atggcccggc tgatttttat atttttagta    480
 gagatggggt tccaccatgt tggccaggct ggtcttgaac ttcctgacct caagtgatcc    540
 acccacctcg gccttcccaa agtggctggg attacagggc gtgaaaccca acacccgggc    600
 cgtaggtttt aactaataat tagggtatta ctctatcatt ctctatcatt caaattctcc    660
 aggtactgac ctggttttta ttttatttat ttatttattt acttatttat ttttgagaca    720
 ggaacaaaac tctgctgccc aggctagagt acagtagtgg cacaatcttg gctcactgca    780
 gtctccacct cctggggttc tattgattcc tgtgcctcag cctcccaagt agctgggact    840
 acaggtgtgc accaccacac caggctaatt tttttatttt tagtagagat ggggtttcac    900
 catgttggcc aggctggtct tgaactcctg acctcaggtg atctgcctgc ctcagcctcc    960
 caaagtgctg ggattacaga tatgaccccc attgtctgcc atcaattctt tatcaatcct   1020
 tagagataac aatgttacca gaaagatcaa caagttgtac cactcagttc agcagtatga   1080
 atcaggaggg ttttaaagct atctgatagg atcactgctg tcctaattgt tcaaagaacc   1140
 gttgcacaca aagatgtagt ttctgtttta actcaagaaa gaaaaagaga aggttcatgt   1200
 catacttctc gtgcc                                                    1215



      <210> 1772
      <211> 1938
      <212> DNA
      <213> Homo sapiens


      <400> 1772
 tttttttttt ttgagtaatg ccgactttat atcagcacac ccagtgcccc cacgttcccg     60
 ctggcccagg tcccggagac catgatggca cccacagtgg acttcgcaaa ggagcgtggg    120
 gaccccgaag gccaggccac ccctcagatg ggggtcccat gctaaagcag acggtgccgg    180
 tgccgcaggc tgtctgagac ccacggtgga gcccgggcct ggcgtgcggg aggcggccac    240
 gacggcgcct ttctcccagg aactccggga gggaccccag gactcagcgc cagggcagcc    300
 ttggcaggtg cagtgaggca gtgacttgtg ggggttagat gtgggcctgc cccacgtggg    360
 cagggatcag ccaggcatgg gggtccagcg gatccgagcg gggccacaga gctctggagg    420
 acttttctgc acaatgaatt tctgcttaaa aacagagatc aagaggaagc tctatcctgc    480
 agctccggaa atgggtggct gcgtgcttgg ggtctccgcc acgcgggagg acagcccaga    540
 ggcaccctgg tctcaggcag ctggttccta ggctgtgtcc tccccactgg ccgggcaccg    600
 gctggaacgg cacgaggacc agcctcactg ttctcagagg ggtctcgggc cactgggtgt    660
 ggtggtgctg gaggagtcct gcccgctgtg ggctctggag ggcacggcag cagagcccct    720
 ggcttttcta ggcagagcgg cacctgcccc atagatcgtg ccagctttgg ctgcaggcgc    780
 tggggcctca ccgtgtttcc tgggggggcc cggaccccca agggcctcga tctgaagctc    840
 tgaggtctca tggatgcctg ctcctggtcc gataaacgag atggctgtgg tggggaggag    900
 cctcaggcgg cccgggaccc tttggcgtcc gtcgctggga ggcggaggga cccagagccg    960
 aggctgtgct caggactgtc ccgggcgccg ggcgatgcca acactttgtg ctggttcccg   1020
 ccaaggggtc ggcctccggg tccctgccgc caagtgcgtg gcgtggtctc ggcctccagg   1080
 tcagacattg ctgatacggg cctcccccgg gaaggcagcg ggatccgtgg ccctgtccag   1140
 gggccgctcc cgcctgacgt agcgcggctt ccgtactgag gactgtggcg gggggatcat   1200
 tgcagccgtt cgccaggctg cagggccgga gctttgtttc ttctgtagca ggccctgggg   1260
 agtttactgg agcgcttgag gtagaagaac ccagctacgg agaggatgag gccggagcta   1320
 atgaagaacg tgcccaggaa gagggaggcg gccacgcgcg gagccccagg atgtggccgc   1380
 ccgggggtcc ctgagcttct gttcatgggg aatggcgcac ccgggccagc aaagctttta   1440
 cactcggagc cgttgtaggc tgggagggtt ccgttcccac agcggacgca gctggcgctc   1500
 ccgtccgcgt tccagcgcct gtaacagcct ggaccacaca gacttgcgcc tgggcagctg   1560
 gcgttgacgc ccaccacatc cacacagcac tcgggcagct gggccgtgtt ctccatggac   1620
 ttgctggcga ctcccacgag aaggccagcc aggagggcga ggtgccgcag cgccatgcca   1680
 ggagcagatg cgcagagcct gcccctccag gatggggact accgacatca gccctttgcc   1740
 cgcctgggtg ttcaggggtt agctctggga gctcatgggc tcagctgagc cctgcagacc   1800
 ccggcccagt cctagaagtg aaatgcgtgc cgacaagagc acggaatata actggagtcc   1860
 gctcgctgag gttctgtgaa gtacatttaa tctccagagg aaccacccgg cacgaaatcg   1920
 tcgacccggg aactccgc                                                 1938



      <210> 1773
      <211> 1166
      <212> DNA
      <213> Homo sapiens


      <400> 1773
 tttttttttt ttacagaatt ccccaaactt taatgctgtg ctctgaaaag ggaggctgga     60
 ggttgtggtg ggtcacagtg ttgctgacac ctctggcctc cagccctgca tccctaggca    120
 ccatgtgacc aggcagtgag aaggacgggg cctcactccc atgccagact gctcctcggg    180
 ctgagcagga cctgaagctc tcagggcttc caccaaagcc cagcaaactt gggggaggcc    240
 tgagggggca tcagcagtcc ttaaaggcct gagcttgcaa cactcaggca ggactcggct    300
 gagggcctct gtggtgccac catggggtag gaggtaaaga gagaccctgg ttccagcctg    360
 ggaaccagtg ggtgccctga agggagggga ggcctcaggg agttcgggac aggagtgtgc    420
 atggtactgg gcggcccatg ggggctcctg gcctcttggt tcaggcaatc cctgagctgg    480
 ggacacattc catcttaggt ccaagagacg gaggtcagga gcatccctag aacgacctcc    540
 caggcacgag gaaggcccgg ggcagggccg ggcgcagcgt ggctggcttc agtaccctcg    600
 ggcatcttga ctcctgccct ctgggactgc aaagggatct gcgggcgcct ctgctgagtc    660
 aatcgtctgg taggcactac ggtcctgaga agacccaagg aaaccagtgt ggaccaggag    720
 ctcacccccg cgctcccggt acatgtggta gacgaagcag caggagagcg gcttgagcag    780
 caagctgagg atggccatgc ccacgccaaa gcggcccgtg tccgtgaggc tgacccgcgg    840
 gtagaagatg ctgatgtgca cgatgtccag gaagatggtg gccagcaagc cacccagaaa    900
 catgcttatg gcgtcgatgg agtcccgctg agccacagcc cacacgccca aggccaggat    960
 ggtgaagttg gcccaggcat aggagcctga gaatacaatg cagccccagg ttgtcagcag   1020
 ccagtgacct aggagaatca ccttcaggtt cacagcaggc agctccatcc cgactcaggc   1080
 cgagggcacc tgcgccgcag ccgcgggggg ctcctaggct ccgaactcgg ggaacaaact   1140
 tgcccggccc cgccccgccc gttgcg                                        1166



      <210> 1774
      <211> 517
      <212> DNA
      <213> Homo sapiens


      <400> 1774
 ggcacgaggg aagagagcta gagactggac aggggagaca gagcagcgtc ggagccgcgc     60
 aggggacggg agtgagagcg ggagtgagag caggaacgac gcagagcggc cgtcgccgtg    120
 cccgggtctc agggcgcctg gctgaagtga gcatggcttc agtggcctgg gccgtcctca    180
 aggtgctgct gcttctcccc actcagactt ggagccccgt aggagcagga aatccacctg    240
 actgtgatgc cccactggcc tctgccttgc ctaggtcatc cttcagcagc tcctcagagc    300
 tgtccagcag ccacggcccg gggttttcaa ggcttaatcg aagagatgga gctggtggct    360
 ggaccccact tgtgtcaaat aaataccaat ggctgcaaat tgaccttgga gagagaatgg    420
 aggtcactgc tgtcgccacc caaggaggat atgggagctc tgactgggtg accagctacc    480
 tcctgatgtt cagtgatggt gggagaaact ggaagca                             517



      <210> 1775
      <211> 517
      <212> DNA
      <213> Homo sapiens


      <400> 1775
 ggcacgaggg aagagagcta gagactggac aggggagaca gagcagcgtc ggagccgcgc     60
 aggggacggg agtgagagcg ggagtgagag caggaacgac gcagagcggc cgtcgccgtg    120
 cccgggtctc agggcgcctg gctgaagtga gcatggcttc agtggcctgg gccgtcctca    180
 aggtgctgct gcttctcccc actcagactt ggagccccgt aggagcagga aatccacctg    240
 actgtgatgc cccactggcc tctgccttgc ctaggtcatc cttcagcagc tcctcagagc    300
 tgtccagcag ccacggcccg gggttttcaa ggcttaatcg aagagatgga gctggtggct    360
 ggaccccact tgtgtcaaat aaataccaat ggctgcaaat tgaccttgga gagagaatgg    420
 aggtcactgc tgtcgccacc caaggaggat atgggagctc tgactgggtg accagctacc    480
 tcctgatgtt cagtgatggt gggagaaact ggaagca                             517



      <210> 1776
      <211> 2388
      <212> DNA
      <213> Homo sapiens


      <400> 1776
 cggacgcgtg ggctgggagc tgtggtgcat gtacatcagc cccccaaaag actggtggga     60
 cgccggagac ccttctctcc ccatcaggac cccagccatg ataggctgct cgttcgtggt    120
 caacaggaag ttcttcggtg aaattggtct tctggatcct ggcatggatg tatacggagg    180
 agaaaatatt gaactgggaa tcaaggtatg gctctgtggg ggcagcatgg aggtccttcc    240
 ttgctcacgg gtggcccaca ttgagcggaa gaagaagcca tataatagca acattggctt    300
 ctacaccaag aggaatgctc ttcgcgttgc tgaggtctgg atggacgatt acaagtctca    360
 tgtgtacata gcgtggaacc tgccgctgga gaatccggga attgacatcg gtgatgtctc    420
 cgaaagaaga gcattaagga aaagtttaaa gtgtaagaat ttccagtggt acctggacca    480
 tgtttaccca gaaatgagaa gatacaataa taccgttgct tacggggagc ttcgcaacaa    540
 caaggcaaaa gacgtctgct tggaccaggg gccgctggag aaccacacag caatattgta    600
 tccgtgccat ggctggggac cacagcttgc ccgctacacc aaggaaggct tcctgcactt    660
 gggtgccctg gggaccacca cactcctccc tgacacccgc tgcctggtgg acaactccaa    720
 gagtcggctg ccccagctcc tggactgcga caaggtcaag agcagcctgt acaagcgctg    780
 gaacttcatc cagaatggag ccatcatgaa caagggcacg ggacgctgcc tggaggtgga    840
 gaaccggggc ctggctggca tcgacctcat cctccgcagc tgcacaggtc agaggtggac    900
 cattaagaac tccatcaagt agagggaggg agctggggca ctggagcctg gcccccagga    960
 catggctgct ccccccaaca tctggaccag ctgccctggc ggagagacag caaggggccg   1020
 gcaggtgctc gatgggcccc ccagggcttc tccagggcag cacagggacc ccggatgaag   1080
 actctgtccc ccctcaggca ttcagctgcc cacaagtttc ctgcaccctg gaaaagcccc   1140
 ccacccttcc tctgggaaac tgacagctgt cttccacagc ctctgatgtg gacctggtac   1200
 tgaggagcaa gactgtccag ttctcctcca catctcccat cccagaatca ggatctggga   1260
 ctggcagggt cccctcctgt gtctcatctc ttgcagcagc agctgctgaa ctccagccat   1320
 caacacggtg ggaggcagcg ggggcttcag ccatgtccta gctccccgcc ctaaaaggag   1380
 gcagtgagga ccaggcacta tttcctccga ggttacttct acccagatga cacctgcctg   1440
 ttcacgcccc aaggcagcta ctgcccctaa cccttcccac cagggtagct ttgggcactg   1500
 cagctctgga cttttctggc ccctcctgag atgacctgat ggagctgatg ctttctctcc   1560
 taatccctgg gcactaggct cttatcaggg tgcttgggcc agctctcctg cctgtgtcta   1620
 gaggaagcca gagacagaaa taggctaagc ctgcagtagg atctcagcca caagggcccc   1680
 gcaggatgga gctgggtcaa ggaccaggga gccctgactc ccagaggctg ccaccgggga   1740
 gaagcagcgg tcctccatcc agaacctaag ggctgaagca aaggctgcca ggacccttga   1800
 agatgctttt ggctcacctc atttcacccc acgctctgct ggctggcaga ggagaaggca   1860
 gtcgtttcct ctctgaagag tatttttttc gattgccctc tggttagggt gcacatataa   1920
 atcagagtta atatatgaac gcgtgtgcat gcacaagtgt gtgtgtgcct gcgtgctgtg   1980
 cgtggcaggg tgtgtgtgtg tgtgtctggc tgtgcgttcc ggagtgtgtg acgatgctga   2040
 ctctagcatg tggggccttg ggcttgctgc ttcattactc accctggatg gggacgaggg   2100
 atgagaaggg tgtgggtttg gcccccatgt cactggccgg aaggatgtgt ctcagccctg   2160
 ccctgtgggg tgcccccgat gggaggctgt cccatctccc agtccccatc tctttttccc   2220
 cacactgtcc ctggccaagc cctgcccaga gctgaaccct gtagctgccc ccttgccctg   2280
 tgtgggattc gcagtgtctc atttggtgac gtcttactgg tgatcatctc ctcaccccat   2340
 ctccaacctt gtggaataaa tacatgttag cacttcccaa aaaaaaaa                2388



      <210> 1777
      <211> 630
      <212> DNA
      <213> Homo sapiens


      <400> 1777
 agagtcaaat agcagatgca ggaagatgcc aggtgaaaga tgccggggtg gcccagctcg     60
 gctgtccctg ctgcttgacc tgcccactcg ccctcttccc cacccccgac aggtgattga    120
 cttcggatcc gccagcattt tcagcgaggt gcgctacgtg aaggagccat acatccagtc    180
 gcgcttctac cgggcccctg agatcctgct ggggctgccc ttctgcgaga aggtggacgt    240
 gtggtccctg ggctgcgtca tggatgagct gcacctgggc tggcctctct accccggcaa    300
 caacgagtac gaccaggtgc gctacatctg cgaaacccag ggcctgccca agccacacct    360
 gttgcacgcc gcctgcaagg cccaccactt cttcaagcgc aacccccacc ctgacgctgc    420
 caacccctgg cagctcaagt cctcggctga ctacctggcc gagacgaagg tgcgcccatt    480
 ggagcgccgc aagtatatgc tcaagtcgtt ggaccagatt gagacagtga atggtggcag    540
 tgtggccagt cggctaacct tccctgaccg ggaggcgctg gcggagcacg ccgacctcaa    600
 gagcatggtg gagctgataa gcgcctgctc                                     630



      <210> 1778
      <211> 692
      <212> DNA
      <213> Homo sapiens


      <400> 1778
 ctcccgggtc gacgatttcg tctggtagtg agctcagacc ctgcagtggg atggggtgct     60
 ctctgctagg tgctgacccc gcacaggtat ggggtgctgt ctgccaggtg ctgaccccgc    120
 agagatccgt tcttccccct ctccttcctg gtcaacagct ggctcccagg gatgctggat    180
 gacctctttc agtccatgtt cctgtgcgcc ctgctgctct tctggctgtg cgtgtaccac    240
 gggattcgtg tccagggaga aagaaagtgt ttaactttct atttgcctaa attcttcatt    300
 gttggactat tgtggttggc ttctgttacg ctaggaatat ggcaaacgga atgaaggtct    360
 tcttcatggt ggtggcagcg gtgtacattc tgtacctctt gttcttgata gtgcgggcgt    420
 gttccgagct acgtcacatg ccttatgtgg caccaccagc cgagttctta tctttctatg    480
 gcctgttgaa cttctatctc tacaccttgg cctttgtata ttctccatcg aagaatgccc    540
 tctatgagtc ccagctgaaa gacaatcctg ccttctccat gctgaatgac tcggatgatg    600
 atgtgattta tgggagtgac tatgaggaaa tgccgctgca gaacggccag gccatccggg    660
 ccaagtacaa ggaggagtca gatagtgact ga                                  692



      <210> 1779
      <211> 1214
      <212> DNA
      <213> Homo sapiens


      <400> 1779
 tttttttttt ttgacagtaa gagcaggttt actgttggca acagcacagc cctgtggcac     60
 ccaagggtag cgggtggggt ggcggccggg tctcctgggg ccccgttctc cctcccattc    120
 tctaggtccc tggaggccag acccctgggt gcggcccatc ctagcagtgg ttctggctgg    180
 gtctgtcctg ggcaggagag gagggtccct ggagaggcag tgatggctac agcgtctgta    240
 gggagctggg gacacttccg gccagccatg acaggcccaa gcctgctcag ctctgcactt    300
 ctggggatcc ccttattcct gactctcccc cctcccccac ctggaagaga cctaggccct    360
 gcaccctaat gaggaggacc ggggtgaggg ggtgcagagt gtcctggggg ggctccgagc    420
 gcttggcagg ggactcagca aggggagcgt agggcgggcc tcacgtctgc agctccagga    480
 ggcagttggg ctctgagggt ggggagccgg ccgggctgga gctatgggcc tcgcggaggt    540
 cctgcagcac ccggagcagc cgggccaatg agtcctcggg gactttgcca gggctcgtgg    600
 gcaccgtgcc tgcctctgcg cccccgctca gctcccggtg cctctcccac agcatggcct    660
 ccacgcccag caggtgccgg tagatgagct gggcctcaag gtcatggtca agagggtcat    720
 tccactcctg cagggtcacc cgtgaccggg tcttatcgca gccctgacct gtcttctctt    780
 tttggtggca gcagctccac ttgtccccac ggaagacgcc agggtggtag gagcccagca    840
 gtccggtgtt gttgatgctc accttccgca gcgcagacag ccactggtta agctcattca    900
 cacacttgga gctgggcgtc ttcgcgaagc tgagggcctc ggtagtgagg gagaagtaga    960
 gcttcttgaa ggaggaggac atgagggggc ccttgccctt ggtcctgtgg atgaagagtg   1020
 gcccctcctt cacaggtggc gcctgcaaac tcagcgtccg ctgcaggtcc agctctgcca   1080
 ggccagggag ggaggggaat agagagccca gtgaatgagg gcgggactgg ggggagcgga   1140
 gcagtgggag gggccatggg gctcaagggc tgagcaaatc tgaacagcag gcagtggacg   1200
 tagtcactcg tgcc                                                     1214



      <210> 1780
      <211> 2653
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2653)
      <223> n = a,t,c or g


      <400> 1780
 gttccccttc ctttcctctg tccaattccc tgagaaagtg gctgacagag cccccccaga     60
 agtagctgga gggacctcag gcccccgaat gcctggagac agaggggtcc cccagtcctc    120
 agcctcactg gcaggcccgg aaagtgctga attcgggggt ctcaggcgag gaggacgtgg    180
 aagtgggcct cttccgggtc ctggagttgc tgggggtggc agtggtgcct gagtgatcat    240
 ccaaggtggc cgggtcttct tctggcatcg ttttcgcgga gacggtaaac agggagttat    300
 cgaaggacat gtctgtgctg tcgaagttaa tctgggccca gcaggattct cgatctcttt    360
 tcttctgtaa atttctgagt ttaacttttc tgaccaccag ggcaacagcc accagcccag    420
 caaggaggaa gagggcacca gccaggctca gggagagcac caagatccaa gtgggcactg    480
 ggaaggagac gttcacgggc tcgctgaggt ctgacagctg ggactggttg agctcaccta    540
 acactccata ctggcagtgg aagggtcccc ctggagcctt gctgctgccg ccgctcaggt    600
 taaatgtcac cccgcgctgg tccgtggggg cctgcaggag ctggaccacc tgcccccctc    660
 gatacagtgt gaaattcgcc cccgggaagt tcccaggggc catgcatgcg atgtggatgg    720
 ggtcctcttg gctgcttggg tacgggggca ccagccggat ggatggtgct gggatcgcca    780
 aggagccagc tgcaaagagc aagatggtcc agggcatctc tctctgcgtt tggctgggaa    840
 atccggctga ggccagaggg gcccaaggct ccccgccaac tcctcctggt ggcccttgag    900
 tctgagaccc ttggggtgca tggtggggcc acgcccctcc actgtctata agccaggaaa    960
 gctgagcact caatatgaac caagcctcat ctcaattctc acagccgcac tacagggtgg   1020
 tcgttccatc actcccgact tacgaggaaa ctgatacgct gatgcctcta aggcgcaaaa   1080
 ggcgtcgaac ctggaccacg ctcacagagc aagcaaaaca cgacgccaca gaccagaggg   1140
 tgacccggat gatggcggcc ggcgcggccc tagccctggc cttgtggcta ctaatgccac   1200
 cagtggaggt gggaggggcg gggcccccgc caatccagga cggtgagttc acgttcctgt   1260
 tgccggcggg gaggaagcag tgtttctacc agtccgcgcc ggccaacgca agcctcgaga   1320
 ccgaatacca ggtgatcgga ggtgctggac tggacgtgga cttcacgctg gagagccctc   1380
 agggcgtgct gttggtcagc gagtcccgca aggctgatgg ggtacacacg gtggagccaa   1440
 cggaggccgg ggactacaag ctgtgctttg acaactcctt cagcaccatc tccgagaagc   1500
 tggtgttctt tgaactgatc tttgacagcc tccaggatga cgaggaggtc gaaggatggg   1560
 cagaggctgt ggagcccgag gagatgctgg atgttaaaat ggaggacatc aaggagtcca   1620
 ttgagaccat gcggacccgg ctggagcgca gcatccagat gctcacgcta ctgcgggcct   1680
 tcgaggcacg tgaccgcaac ctgcaagagg gcaacttgga gcgggtcaac ttctggtcag   1740
 ctgtcaacgt ggcggtgctg ctgctggtgg ctgtgctgca ggtctgcacg ctcaagcgct   1800
 tcttccagga caagcgcccg gtgcccacgt agcccctgcc atggaaggaa gaacgggaca   1860
 aaggaggggc agcagggtgt gtgcatatga gacttggggg tccctcccca attttagttt   1920
 cctgccaaaa cgggagtgtg cagtcagggc ctgcggtctg gccccatgag tctccttccg   1980
 tcctcagcgg gcagggaaca cctctggctt gtagaaggga cggctcagtg gctgcaccga   2040
 cggtcctgga aatctcacat ggtgggcact gcagcgttgg aacgtgagcc tcggatttcc   2100
 tggcccctct actgtaaatg tgccttagcc taagcctccc atcctgtgtt agcgttgcct   2160
 ggtgtggggc agggcctaac aaggaaacct gggccctcca agccaggttg aggtctggta   2220
 acagaatgcc aggaaggggg cctggaagac cacctgcccc ggcccctctc ctgcaggggc   2280
 cccacacagg catgagggat ggcccggcca aagtctaggc agaagcctcc tataacaaag   2340
 ggtggtgtgg cctgggcatt ggagtcaata aattatggtc agaaaatcac aagagcctgc   2400
 tgattggggc tcagggacac cagccaggac agaccggccc ccgagggggc agccagacag   2460
 gtgggagggg cctcccacga agctcagaag aaaggtcgtg cgggagccga tggaggtggt   2520
 cgcctgggca ctcctggggg aatccctggg gggatccgaa ctggccgaga tgggatctga   2580
 ggcggggctg ggaagaggaa ttccaccaca tggactagtg tnctcgatnn anggnnntca   2640
 actggctgtc cct                                                      2653



      <210> 1781
      <211> 456
      <212> DNA
      <213> Homo sapiens


      <400> 1781
 atgtgtcaac acttttggga gctacatctg caagtgtcat aaaggcttcg atctcatgta     60
 tattggaggc aaatatcaat gtcatgacat agacgaatgc tcacttggtc agtatcagtg    120
 cagcagcttt gctcgatgtt ataacgtacg tgggtcctac aagtgcaaat gtaaagaagg    180
 ataccagggt gatggactga cttgtgtgta tatcccaaaa gttatgattg aaccttcagg    240
 tccaattcat gtaccaaagg gaaatggtac cattttaaag ggtgacacag gaaataataa    300
 ttggattcct gatgttggaa gtacttggtg gcctccgaag acaccatata ttcctcctat    360
 cattaccaac aggcctactt ctaagccaac aacaagacct acaccaaagc caacaccaat    420
 tcctactcca ccaccaccac cacgaattcc accgca                              456



      <210> 1782
      <211> 1435
      <212> DNA
      <213> Homo sapiens


      <400> 1782
 ctctgaggag acactttttt tttcctccct ccttccctcc tctcctcctc ccttcccttc     60
 ccctctcctc ccctctctcc tccttccccc ctcggtccgc cggagcctgc tggggcgagc    120
 ggttggtatt gcaggcgctt gctctccggg gccgcccggc gggtagctgg cggggggagg    180
 aggcaggaac cgcgatggcg cctcagaagc acggcggtgg gggagggggc ggctcggggc    240
 ccagcgcggg gtccggggga ggcggcttcg ggggttcggc ggcggtggcg gcggcgacgg    300
 cttcgggcgg caaatccggc ggcgggagct gtggaggggg tggcagttac tcggcctcct    360
 cctcctcctc cgcggcggca gcggcggggg ctgcggtgtt accggtgaag aagccgaaaa    420
 tggagcacgt ccaggctgac cacgagcttt tcctccaggc ctttgagaag ccaacacaga    480
 tctatagatt tctttgaact cggaatctca tagcaccaat atttttgcac agaactctta    540
 cttacatgtc tcatcgaaac tccagaacaa acatcaaaag gaaaacattt aaagttgatg    600
 atatgttatc aaaagtagag aaaatgaaag gagagcaaga atctcatagc ttgtcagctc    660
 atttgcagct tacgtttact ggtttcttcc acaaaaatga taagccatca ccaaactcag    720
 aaaatgaaca aaattctgtt accctggaag tcctgcttgt gaaagtttgc cacaaaaaaa    780
 gaaaggatgt aagttgtcca ataaggcaag ttcccacagg taaaaagcag gtgcctttga    840
 atcctgacct caatcaaaca aaacccggaa atttcccgtc ccttgcagtt tccagtaatg    900
 aatttgaacc tagtaacagc catatggtga agtcttactc gttgctattt agagtgactc    960
 gtccaggaag aagagagttt aatggaatga ttaatggaga aaccaatgaa aatattgatg   1020
 tcaatgaaga gcttccagcc agaagaaaac gaaatcgtga ggatggggaa aagacatttg   1080
 ttgcacaaat gacagtattt gataaaaaca ggcgcttaca gcttttagat ggggaatatg   1140
 aagtagccat gcaggaaatg gaagaatgtc caataagcaa gaaaagagca acatgggaga   1200
 ctattcttga tgggaagagg ctgcctccat tcgaaacatt ttctcaggga cctacgttgc   1260
 agttcactct tcgttggaca ggagagacca atgataaatc tacggctcct attgccaaac   1320
 ctcttgccac tagaaattca gagagtctcc atcaggaaaa caagcctggt tcagttaaac   1380
 ctactcaaac tattgctgtt aaagaatcat tgactacaga tctacaaaaa aaaaa        1435



      <210> 1783
      <211> 1760
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1760)
      <223> n = a,t,c or g


      <400> 1783
 tttttttttt ttgcaatgaa aaccctttaa tgttgggctt tctttaaata aaacagaaag     60
 gttgcagctt tcccatggtg gctgtaaggc aagaacagca gtgagggcgg gcgtgttcta    120
 tcgggcagtg ctgcagccct tgactctggc tcaaggtggg cttcctggag gcagcggcaa    180
 ggaggcagtt ctggatgtgc aggcacagat gtaggggaac aggcaagcgg gcacagggcc    240
 ctgagctgac aagcagtgac ccctgcaccc agctagatgg ggcaccccct ctctgggagc    300
 tgagggcatc agctggagcc tcaggctggg accagcccca actttgcctt ggtgactctg    360
 ggccattcca ggcctcagtt tccccagctg taaggtgagg cattaggcag gagggggtgg    420
 ccccagccag tgtcctagta gcctggtgtc tccattaggg agacctgaga agctgccagg    480
 agaggctctg ctagcgcaag gcagggccgg cccagcagct gacaaggaac atgctgaata    540
 tagaggacag aggagttaag aagacgcctg ccggccaggc cagagagggg cagctctaag    600
 ggggtacagc ggcctgtggt gctgtaggcc cagaaagggt ggggatcagc ccaagtcaca    660
 gagcatggcc ctggtgggcg gcgaggggtg cgagtggaca aggacacccc tgcagagtcc    720
 cacccccact ctattccctc caacaaggga acgcccagca ggaagcctgc tgtctttcca    780
 ggagcccctg tgccacctag tctgacccct ctcagccaca aggctaccct cccgtccagc    840
 ctgactggag gtagaggagg aggaggaggc aaggccgact gcagtgggga gcccgggtgc    900
 cccgtcctct gtcagcaaat gcctcccttc catctgcctc tagccccggc ctctgaccac    960
 ccaggctctg ccccaggcct gcaaccacct cagcggaagc cagaggggct gcctggcaga   1020
 tgccgctctg acccttcagg agtgcccact gcacctgaat caggcccagg ccctggagag   1080
 cccaggcctg tacccaggat gctctggtct ggccctgcct cggcccttgc agtggtccga   1140
 gccaggatct aggctcggga ggcacttgtg ggtccctttg ctccaggcac catcctcccc   1200
 tacctaggcc cacatgagtg gcctcatcgt agggccaggc aggactctcc tttgcccatc   1260
 catccccacc ttgagggcag agctgggtca ggatgccaat gccactcctc cttctgccta   1320
 gcgtggagcc cagcacagag gggtatcaat aactgggggg gcccagtggg tggagcaggg   1380
 tgggccaggc tggtcaggag gctactccag ctggaacaga gtatggctga gactgcccat   1440
 ctgtgggcag cccccaggcc caggatggtg gccagggcag acggtgtgaa ggtggcggtc   1500
 actggtcctt ggtgacatca ctgagcccac tctccatgcg gagcagctgg ctgctggcct   1560
 cgttgtagga gatccagtgc tgcagatcag cgggcagctc agggggctcc accctgcgct   1620
 ggcacaggtg ctgcacgacg cgctcgggtg aggtgcccag caggtgctgc cggaagcgca   1680
 gcagcgcgca cacgaaaccg tcccgcaggc tgacaaagcg cgcctccagg tagaacgcgc   1740
 ggaagtcgnn aaaacgggtc                                               1760



      <210> 1784
      <211> 429
      <212> DNA
      <213> Homo sapiens


      <400> 1784
 tattatgaca gtgcggtgga attcgtggag tgagtctgag gacagcagat gaacagacag     60
 aaactgaaag atcccctaat ttgatgagtg agagggtcga gcggaactgg agcacgggcg    120
 gctggctgct ggcactgtgc ctggcctggc tgtggaccca cctgaccttg gctgccctgc    180
 agcctcccac tgccacagtg cttgtgcagc agggcacctg cgaggtgatt gcggctcacc    240
 gctgctgcaa ccggaaccgc atcgaggagc gctcccagac ggtgaaatgc tcctgttttt    300
 ctggccaggt ggccggcacc acgcgggcaa agccctcctg cgtggacgac ctgctcttgg    360
 ctgcccactg tgctcgtaga gaccctagag ctgcactccg cctcctgctt ccacagcctc    420
 catcgtcct                                                            429



      <210> 1785
      <211> 429
      <212> DNA
      <213> Homo sapiens


      <400> 1785
 tattatgaca gtgcggtgga attcgtggag tgagtctgag gacagcagat gaacagacag     60
 aaactgaaag atcccctaat ttgatgagtg agagggtcga gcggaactgg agcacgggcg    120
 gctggctgct ggcactgtgc ctggcctggc tgtggaccca cctgaccttg gctgccctgc    180
 agcctcccac tgccacagtg cttgtgcagc agggcacctg cgaggtgatt gcggctcacc    240
 gctgctgcaa ccggaaccgc atcgaggagc gctcccagac ggtgaaatgc tcctgttttt    300
 ctggccaggt ggccggcacc acgcgggcaa agccctcctg cgtggacgac ctgctcttgg    360
 ctgcccactg tgctcgtaga gaccctagag ctgcactccg cctcctgctt ccacagcctc    420
 catcgtcct                                                            429



      <210> 1786
      <211> 3046
      <212> DNA
      <213> Homo sapiens


      <400> 1786
 atggccgtga caccagtgac tggagagact gtggacaccc atggctgtga caccagtgat     60
 ctggagagac tgtgggtcac ccagggccgt gacaccagtg actgcagaga ctgtgggaca    120
 cccatggccg tgacaccagt gactggagac tgtgggacac ccatggccgt gacaccagtg    180
 actggagaga ctcacatcct catcagactc ctcaatacac caaagcacat cctcatcaga    240
 ctcaatacac caaagcacat tctcatcaga cacctcaata caccaaagca catcctcatc    300
 agactcaata caccaaagca cattctcatc agactcaata caccaaagca cattctcatc    360
 agacacctca atacaccaaa gcacatcctc atcggactca atacaccaaa gcacatcctc    420
 atcagactcc tcaatacacc aaagcacatc ctcatcagac acctcaatac accaaagcac    480
 accctcatca gacacctcaa tacaccaaag cacattctca tcagtcacct caatacacca    540
 aagcacatcc tcatcagact caatacacca aagcacattc tcatcagaca cctcaataca    600
 ccaaagcaca tcctcatcag actcaataca ccaaagcaca tcctcatcag actcaataca    660
 ccaaagcaca tcctcatcag acacctcaat acaccaaagc acattctcat cagactcctc    720
 aatacaccaa agcacatcct catcagactc ctcaatacac caaagcacat cctcatcaga    780
 ctcctcaaaa ccagtgtggt gtccatgggc tctggagacc atcagttcaa cctcgcagag    840
 atcctgtcac agaactacag tgttaggggg gagtgcgagg aggcctcgag gtgcccagac    900
 aagcccaagg aggagctgga gaaggacttc atctcccaga aacccacgag ccgatttcaa    960
 aagcatatgg aagctcaagg taccccaaac agcccaaaca atcttgaaac aatacttcct   1020
 gatttcaaaa ttcaccacag agccacagca atcaaaacag tgtggtactg ccataaggac   1080
 agcacaaaga tcaacgaact agaactgaga atccagaaat acagtcacac attcatagtc   1140
 aactggattt ccacaaagag aataaaaact gtgctcaaaa agacagtaac aagtgttgac   1200
 aagaacgtgg acaaagtgga actctcctgt gccctgccgg gcctcctcca cattgaagtt   1260
 gcatttcacc aactcgtaca gcgcctgggg agaggacatg ttggctcttc catgggctca   1320
 gcgcaggagc cgacagcaag aactgtctat accatccagc gagtggcatc aggggccgtc   1380
 cacaccaccc tcctgggcga tgtcagagcc acctacacct ctatccaggg agtgacatca   1440
 gggcccgtcc acaccaccct cctgggcgat gtcagggcca cctacacctc tatccaggga   1500
 gtgacatcag gggccgtcca caccaccctc ctgggcgatg tcagggccac ctacacctct   1560
 atccagggag tgacatcagg ggccgtccac accaccctcc tgggcgatgt cagggccacc   1620
 tacacctcta tccagggagt gacatcaggg gccgtccaca ccaccctcct gggcgatgtc   1680
 agggccacct acacctctat ccagggagtg acatcagggg ccgtccacac caccctcctg   1740
 ggcgatgtca gggccaccta cacctctatc cagggagtga catcaggggc cgtccacacc   1800
 accctcctgg gcaatgtcag ggccacctac acctctatcc agggagtgac atcaggggcc   1860
 gtccacacca ccctcctggg cgatgtcagg gccacctaca cctctatcca gggagtgaca   1920
 tcaggggccg tccacaccac cctcctgggc gatgtcaggg ccacctacac ctctatccag   1980
 ggaggactgg catcagggcc cgtccacacc accctcctgg gcgatgtcag agccacctac   2040
 acctctatcc agggactggc atcaggggcc gtccacacca tcctcctggg cgatgtcagg   2100
 gccacctaca cctctatcca gggagtgaca tcaggggtgt cccaggtatc cagggcagcc   2160
 caaatggcag tccccagctc gcggatcctc cagttgtcaa agccgaaggc cccagccacc   2220
 ctcttggaaa gagtgggacc ccgtgccaaa acccaagcca catgtgtcag accataaccg   2280
 cctccttcac ttggccaaag ttccacgcaa agagggatct ggaaagaagg tgggagcttt   2340
 cccagaaatc aaaggccctg aagccttcag agacaaggcg agggccatgg aatcacagag   2400
 caacgacatg ccctttgatg agctgcttgc gctctatggc tacgaggcgt cagaccccat   2460
 ttcagaccgg gagagtgagg gtggtgacgt ggacccgaac ctcccagaca tgaccctgga   2520
 caaagaacaa atagcgaagg atttgctttc aggggaagaa gaggaagaga cgcaatcatc   2580
 tgctgacgac ctcaccccgt ccgtgacctc ccacgaggcc tccgacctct tccctaaccg   2640
 gagtggatgc ctcctcgctg gggaggcaga gtcctcgcgt ggtctcctgc ctcgagcaca   2700
 gcctgtgccc aggggagccg ggcttgcaga caacagcagg ggggccctcc tgagggccca   2760
 cgggactgtc agagtcggaa cgacagccac agtcaaacca gccgacgctc ctcctgagag   2820
 cccacgggac cgtcggagtc ggaacgacag ccacaggccc acgggaccgt cagagtcgga   2880
 acgacagcca cagtcaaacc agccgacgct cctgctgagg ggccacggga ccatcagagt   2940
 cagaacgaca gccacggtca aaccagccga cgctcctgct gagagcccac gggaccgtcg   3000
 gagtcggaac gacagccacg gtcaaagcag ccgacgctcc tgctga                  3046



      <210> 1787
      <211> 2735
      <212> DNA
      <213> Homo sapiens


      <400> 1787
 ttagattcag ctttgggaat ttgttccagg aactgcatca tccagcccaa aagcaaaaga     60
 ggaaaatgca taagccagga tacctaaatg ttcctttatt taaacttgaa aatgtgactg    120
 caaaaggagt caagaagttt agtactcaac acatttcttc tttgtagaaa taactgctca    180
 agaagataaa ttgttaccta acagttgatt gatgaatatg aaatcagagc aagaggggct    240
 aattagagaa attactagct agggctattt acccaaacca tctatccaga ctgtagacat    300
 agaatcacca gatggctagg atcctggtgc agctggttcc cctttttcct taccctgaat    360
 gtcattaagg atgcattgcc aaatgctgcc cctctggcct gatgactaca ctccatattg    420
 gtcacctgcc ttctttttcc tacagtcttc ctccagacag gcacgccata caaccgacta    480
 cacttgggct cactgaatga atcacattct tctgctgtgc ctcccagaga tttcatcaaa    540
 gcacccgcag tggccttctg gaggctcctc aaactctcca ctcaatgttt cctgaaagtg    600
 tcgtgtttct cacctctaga ttgttattct catcagttac atgtgggttt cacaaattta    660
 tttctcagaa tgcaagtctg tctcttatat cctcgggaaa cacaccttta tatcccagtt    720
 agtactgaca aaaattaaac tagggactgg ccaaaaacag tgcctttcct cactttaatc    780
 tcactaaagt agataagact caagttattt tgttcttgca atggcattga caaatgtttg    840
 caccaaaaac catgttgaag ttcattaagg aaactgtgat ccaagatcca aggtcaaaaa    900
 aacaaattca tcaattcagc acaccaccaa ctcacaggct aagcatctta ctgctaattc    960
 attgatgctg ccatttgtca agtgccaaat tgaattattg atttgtcaat aatttccttc   1020
 cgttggttac ttatatagta tattgcaatt cttgttgctg aagtcagcta cactttttct   1080
 atttgaaaaa caatttcttg catttgggat ttcaggtata gtgattgtta caaatatgaa   1140
 ggacttgaat taacagcaag ttttcaagta aaactttact tatgtataac tgaatgagtt   1200
 cttaaagaca tttactaaca attttccaca aactaaaaat ttataaaaca ataaataaaa   1260
 tagactttaa aaaaaagcgt gtcacacagc tgcttgtttt ttgtttgttt ctttgtttgt   1320
 tttttagtag tgaaatggtg aaaaatcaga caatggtcac agagttcctc ctactgggat   1380
 ttctcctggg cccaaggatt cagatgctcc tctttgggct cttctccctg ttctatgtct   1440
 tcaccctgct ggggaatggg accatcctgg ggctcatctc actggactcc agactccaca   1500
 cccccatgta cttcttcctc tcacacctgg ccgtcgtcaa catcgcctat gcctgcaaca   1560
 cagtgcccca gatgctggtg aacctcctgc atccagccaa gcccatctcc tttgctggct   1620
 gcatgacata gacctttctc tttttgagtt ttgcacatac tgaatgcctc ctgttggtgc   1680
 tgatgtccta cgatcggtac gtggccatct gccaccctct ccgatatttc atcatcatga   1740
 cctggaaagt ctgcatcact ctggccatca cttcctggac atgtggctcc ctcctggcta   1800
 tggtccatgt gagcctcatc ctaagactgc ccttttgtgg gcctcgtgaa atcaaccact   1860
 tcttctgtga aatcctgtct gtcctcaggc tggcctgtgc tgatacctgg ctcaaccagg   1920
 tggtcatctt tgcagcctgc atgttcatcc tggtgggacc actctgcctg gtgctggtct   1980
 cctactcaca catcctggcg gccatcctga ggatccagtc tggggagggc cgcagaaagg   2040
 ccttctccac ctgctcctcc cacctctgcg tagtgggact cttctttggc agcgccatcg   2100
 tcatgtacat ggcccctaag tcccgccatc ctgaggagca gcagaaggtc ctttttctat   2160
 tttacagttc tttcaacccg atgctaaacc ccctgattta caacctgagg aatgtagagg   2220
 tcaagggtgc cctgaggaga gcactgtgca aggaaagtca ttcctaagag gtgtgacatt   2280
 tgaactgcca gcctcagttg tcacgtggac tcttgatgcc caattattgc ctcaatccag   2340
 aaaagtttac ttctctttat ctgtgcttta ctgacagaag ggcaagtctt ctctcgtttt   2400
 ttgcagataa aattttagat gtgttgcatt cattgggttt ctatgagatg tggttttatc   2460
 agacaatttt ttcttttatt tcacaattac tttaatatct ttgaccagca aatatctcca   2520
 ccctccaggg agaggtagta gcttctaggg aaaccatctt ggagagggtc ctgtcttccc   2580
 ctgaggtggg ctttgaatcc agcactcttc cccttggagg gtcacttgga accagctaac   2640
 ttttcagggt cctttcttcc cagttctgct catacatctg tcatgtaaca ctttagtgtt   2700
 ctatatttgc atagctgtat ccttccatta gtttg                              2735



      <210> 1788
      <211> 2735
      <212> DNA
      <213> Homo sapiens


      <400> 1788
 ttagattcag ctttgggaat ttgttccagg aactgcatca tccagcccaa aagcaaaaga     60
 ggaaaatgca taagccagga tacctaaatg ttcctttatt taaacttgaa aatgtgactg    120
 caaaaggagt caagaagttt agtactcaac acatttcttc tttgtagaaa taactgctca    180
 agaagataaa ttgttaccta acagttgatt gatgaatatg aaatcagagc aagaggggct    240
 aattagagaa attactagct agggctattt acccaaacca tctatccaga ctgtagacat    300
 agaatcacca gatggctagg atcctggtgc agctggttcc cctttttcct taccctgaat    360
 gtcattaagg atgcattgcc aaatgctgcc cctctggcct gatgactaca ctccatattg    420
 gtcacctgcc ttctttttcc tacagtcttc ctccagacag gcacgccata caaccgacta    480
 cacttgggct cactgaatga atcacattct tctgctgtgc ctcccagaga tttcatcaaa    540
 gcacccgcag tggccttctg gaggctcctc aaactctcca ctcaatgttt cctgaaagtg    600
 tcgtgtttct cacctctaga ttgttattct catcagttac atgtgggttt cacaaattta    660
 tttctcagaa tgcaagtctg tctcttatat cctcgggaaa cacaccttta tatcccagtt    720
 agtactgaca aaaattaaac tagggactgg ccaaaaacag tgcctttcct cactttaatc    780
 tcactaaagt agataagact caagttattt tgttcttgca atggcattga caaatgtttg    840
 caccaaaaac catgttgaag ttcattaagg aaactgtgat ccaagatcca aggtcaaaaa    900
 aacaaattca tcaattcagc acaccaccaa ctcacaggct aagcatctta ctgctaattc    960
 attgatgctg ccatttgtca agtgccaaat tgaattattg atttgtcaat aatttccttc   1020
 cgttggttac ttatatagta tattgcaatt cttgttgctg aagtcagcta cactttttct   1080
 atttgaaaaa caatttcttg catttgggat ttcaggtata gtgattgtta caaatatgaa   1140
 ggacttgaat taacagcaag ttttcaagta aaactttact tatgtataac tgaatgagtt   1200
 cttaaagaca tttactaaca attttccaca aactaaaaat ttataaaaca ataaataaaa   1260
 tagactttaa aaaaaagcgt gtcacacagc tgcttgtttt ttgtttgttt ctttgtttgt   1320
 tttttagtag tgaaatggtg aaaaatcaga caatggtcac agagttcctc ctactgggat   1380
 ttctcctggg cccaaggatt cagatgctcc tctttgggct cttctccctg ttctatgtct   1440
 tcaccctgct ggggaatggg accatcctgg ggctcatctc actggactcc agactccaca   1500
 cccccatgta cttcttcctc tcacacctgg ccgtcgtcaa catcgcctat gcctgcaaca   1560
 cagtgcccca gatgctggtg aacctcctgc atccagccaa gcccatctcc tttgctggct   1620
 gcatgacata gacctttctc tttttgagtt ttgcacatac tgaatgcctc ctgttggtgc   1680
 tgatgtccta cgatcggtac gtggccatct gccaccctct ccgatatttc atcatcatga   1740
 cctggaaagt ctgcatcact ctggccatca cttcctggac atgtggctcc ctcctggcta   1800
 tggtccatgt gagcctcatc ctaagactgc ccttttgtgg gcctcgtgaa atcaaccact   1860
 tcttctgtga aatcctgtct gtcctcaggc tggcctgtgc tgatacctgg ctcaaccagg   1920
 tggtcatctt tgcagcctgc atgttcatcc tggtgggacc actctgcctg gtgctggtct   1980
 cctactcaca catcctggcg gccatcctga ggatccagtc tggggagggc cgcagaaagg   2040
 ccttctccac ctgctcctcc cacctctgcg tagtgggact cttctttggc agcgccatcg   2100
 tcatgtacat ggcccctaag tcccgccatc ctgaggagca gcagaaggtc ctttttctat   2160
 tttacagttc tttcaacccg atgctaaacc ccctgattta caacctgagg aatgtagagg   2220
 tcaagggtgc cctgaggaga gcactgtgca aggaaagtca ttcctaagag gtgtgacatt   2280
 tgaactgcca gcctcagttg tcacgtggac tcttgatgcc caattattgc ctcaatccag   2340
 aaaagtttac ttctctttat ctgtgcttta ctgacagaag ggcaagtctt ctctcgtttt   2400
 ttgcagataa aattttagat gtgttgcatt cattgggttt ctatgagatg tggttttatc   2460
 agacaatttt ttcttttatt tcacaattac tttaatatct ttgaccagca aatatctcca   2520
 ccctccaggg agaggtagta gcttctaggg aaaccatctt ggagagggtc ctgtcttccc   2580
 ctgaggtggg ctttgaatcc agcactcttc cccttggagg gtcacttgga accagctaac   2640
 ttttcagggt cctttcttcc cagttctgct catacatctg tcatgtaaca ctttagtgtt   2700
 ctatatttgc atagctgtat ccttccatta gtttg                              2735



      <210> 1789
      <211> 371
      <212> DNA
      <213> Homo sapiens


      <400> 1789
 gactgttact ctcgaggctg aggcaggaga atcgcttgaa ccgggaggta gaggtttcag     60
 tgagccaagg tgacaccact gcactccagc ctgagcgaga aagcgaaact atgtctcaaa    120
 aataaaaaaa ataaactttg tagtttgttt tacccggata caaagttgtc attaacattt    180
 ttacttttgt ttttcagata ttaacctggc tgcagagcca aaagtgaacc gaggaaaagc    240
 aggtgtgaaa cgatctgcag cggagatgta cgggtcagta acagaacacc cttctccgtc    300
 ccctctactc aggtccggaa ctttattatt tataactgca ttgtgtccat cagtgggcat    360
 cttctctttc t                                                         371



      <210> 1790
      <211> 3870
      <212> DNA
      <213> Homo sapiens


      <400> 1790
 gacattagtc cgtgtggtgg aattcgccta gtgtggggct gagggtgcgg gtcgctatgg     60
 cggtggacat cacgctgcta ttccgggcca gcgtcaagac cgtgaagacg cggaacaagg    120
 cgctgggagt ggcggtgggc ggcggggtcg atggcagccg ggacgagctg ttccgccgga    180
 gcccccggcc caagggcgac ttctccagcc gggcccgcga agtgatttct cacattggca    240
 aactgagaga ttttcttctg gaacacagga aagattatat taatgcttat agccatacca    300
 tgtctgaata tgggaggatg acagacacag aacgagacca gatagaccag gatgcccaga    360
 tattcatgag gacctgttca gaagcaattc agcaactacg aacagaagct cacaaggaga    420
 tacattccca gcaagtgaag gagcacagga ccgctgtttt ggatttcatt gaagattact    480
 tgaaaagagt atgtaaactt tactcagaac agagagccat ccgagttaaa agagtggtgg    540
 ataagaaaag attatctaag ctggaaccag aaccaaatac aaagacaaga gaatccacat    600
 cttctgagaa agtttcacag agtccttcaa aagactctga agaaaaccct gccactgaag    660
 aacgtccaga aaaaattttg gctgaaacac aacctgaatt gggaacgtgg ggagatggca    720
 aaggcgaaga tgagttatcc ccagaagaaa tacaaatgtt tgaacaggaa aatcagcgac    780
 taattggtga aatgaacagc ttgtttgatg aagtgaggca aatcgaaggg agagtggttg    840
 agatttccag actccaagag atattcacgg aaaaggtttt gcaacaggaa gctgagattg    900
 acagcattca ccagttagtt gtgggggcaa ctgaaaatat caaggaaggc aacgaagaca    960
 taagagaggc cattaaaaac aacgctggct tccgcgtgtg gatcctcttc ttcctcgtga   1020
 tgtgctcctt ctccttgctc ttcctcgact ggtacgacag ctagccaggg ccacgggggc   1080
 ccagcacgag agtcctcatg ggcactcaca gactgcgtgc tttcatgtac ttccagtgct   1140
 ggagcatggt atgaccagat tttatcacag tgccatttga agggaaagga gttcagacag   1200
 acagacgtat tccccaaaaa gggatacccc aggccgatgg tgttcagcca tttagcagct   1260
 gaaaaaggaa acagtgcaca ccaatgggag gcagcctgcg tagccctcat caggcaagac   1320
 agactgaatg caggagtggg tgattagctg ctccttgaac ttgaggctgc cttggcagca   1380
 ggggcacagc aggcctcaag agcccctaat tgtctcaggg ttcaaaggaa gacactgacc   1440
 tttcccatcc cggtagcttc agggaagatc atagttaata acgtctctca acaaatgatt   1500
 acttctttgt ttccttgtgg cttcttgtct gtctgagtca acgaatacac agacttactg   1560
 gattatagaa gagaaaattc acatctgcct tgttaatcta ataaatataa ttacagcccc   1620
 ttaatgtgtt gtcaatgagt ctaagttgac aaattcagtg gcagcccagc cacctcctat   1680
 caatcaatca gggaagaaat gcaggggaga ctggggccct cagtgagggg ctgcctggca   1740
 ttactcctcc aaagactgct gcccccagag caggcagggg gtgtgggagg gccagtttcc   1800
 cgccactggg tccaaggagc ctttgttcaa aggaagaagt gggccacgga agaacgggcc   1860
 tgcttctctc gtgcctgtgc ttctgacctc caggaactgt aaacaggaac acctatgtgt   1920
 aactgaaggc atgagacatc tgtacaggaa gcatcccagc gcccacatgg gcatgagaca   1980
 gtctgcactg cgcctggtga aatgcgtgtg tgtacagaca gtccactggg cagcacaggt   2040
 atcctcatgt tctttatttg cacagagtga aatgtcagaa gttacatgta aatgaattca   2100
 cagtcaataa agtccacgtc tacctggaaa taccaggctc ggcctctgca ctgtgcgcac   2160
 acgggcttca cttgtgtcta tttcagatgc gcagggaagc tttcggcact gatttattgc   2220
 tcttgagtca ttttcccaca gcttaacacc acccttctca ggcacacggc ctgctgatgc   2280
 acaccgctgc gccaaggtca cgggtctgtg tctccagaca cccttgatga gaaaatacat   2340
 tttctgtctt agaagcacat ttcaggaaac aagagtggcg ctgaccacgg tcaccatgcc   2400
 tgttcacaac acatctcaca ctatttgtcg tttatttctg atctaaaaaa ctgaaacttt   2460
 tgacacgtac accagaaaca acacattcaa taacatagaa gaaatgtctg cgaatgtctt   2520
 ttctatttgt tttacacact tttagttcat ctaactggca gttttgtaaa cataaacttt   2580
 aatatcaaga ttcaaactgg aacaattttc ttacaaagat tgtgagttga aatttgtcat   2640
 tttgtttgca cggtgccaca ccagtccccc acccccaccc cacagccttt cctgcctgtt   2700
 tcccacatca agggatatca gtttcataga ataaaaatta aagtagctca agcttaccag   2760
 aaattacatt tccacttttc ccacccagct catttcttta aaaactaatg gggctattgg   2820
 tgcaaattta ttcataatag aagtgaacca gagggccagt gggggctctt tcctatcagc   2880
 acatcacaga gcagacagac tacctgcagg gagagttctg cacctcacgg ggcccgggcg   2940
 ttctcttccc aggccctttt cccttcacat ggtttgccag ttttacacac atgggggcaa   3000
 accccagctg tctccaccca gatggggtgt gcccctccct ccttaccaag atgccagagt   3060
 cagaggggag ggagtagtca atccacaccg agcctgccac attgcagggc cgtccacccg   3120
 actcaggagt cagcacagga gggtgggggg tcttttcctc gtctctatgc cacttactta   3180
 ctacagtgca ccttggcagc agtcagcact gttacccgct gatggccgag gaagaaatgc   3240
 gaagtaggct tgctcttagc acagcgagag atcactctag atatggctat ggaggaaggt   3300
 ttgcagacag cagggtcggt tcagaaaatc aattccacaa aatgcattta tctgagatcc   3360
 aaacccttcg catatccagt gtaaatttat ttttttacag catccaataa atcccagtaa   3420
 aggagctaaa tgaagatctt aacatgaaaa gtggtgtcag agctctttag gcaatgctga   3480
 aatgcacttg attttatgcc cgtgggtggt cggcagcaag ttttatttgc aaagcagcat   3540
 tagcaaacag aagcaattgc accgtaaatg agtaacctct aaagtatcag taattatatt   3600
 taatgaaatg tccctcaaag tccctttgtt atttgcaagt gacacattgt aaggaacttg   3660
 cccatcccgc taagctgact tctcagccgc ttcagtctcc tgctcggaca gcttctcttc   3720
 tgacagaact gacatccagg gcgatacgga gcgcgtgatg ctctgcttgg ccaggttgta   3780
 gtggtttatg actgtgtaaa atttctcccg ggcactggag tcttgctccg cgtagtagct   3840
 ctccaagcct tctgggatgc actgggtgtt                                    3870



      <210> 1791
      <211> 827
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(827)
      <223> n = a,t,c or g


      <400> 1791
 tccgggtcgt cccacgcgtc cgacggatca gggttccagg aactcaggat ctgcagtgag     60
 gaccagacac cactgattgc aggaatgtgt tccctcccca tggcaagata ctacataatt    120
 aaatatgcag accagaaggc tctatacaca agagacggcc agctgctggt gggagatcct    180
 gttgcagaca actgctgtgc agagaagatc tgcacacttc ctaacagagg cttggaccgc    240
 accaaggtcc ccattttcct ggggatccag ggagggagcc gctgcctggc atgtgtggag    300
 acagaagagg ggccttccct acagctggag gatgtgaaca ttgaggaact gtacaaaggt    360
 ggtgaagagg ccacacgctt caccttcttc cagagcagct caggctccgc cttcaggctt    420
 gaggctgctg cctggcctgg ctggttcctg tgtggcccgg cagagcccca gcagccagta    480
 cagctcacca aggagagtga gccctcagcc cgtaccaagt tttactttga acagagctgg    540
 tagggagaca ggaaactgcg ttttagcctt gtgcccccaa accaagctca tcctgctcag    600
 ggtctannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    660
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    720
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnaaggagg    780
 caggaaggga gagtcagaga gagaatggaa gataccatgc ttctaat                  827



      <210> 1792
      <211> 569
      <212> DNA
      <213> Homo sapiens


      <400> 1792
 aaatcttgaa cgagcgcctt gctaactacc tgcaaaaggt gcgaatgcta gaacgagaga     60
 atgctgaact ggaatctaaa atccaggaag aaagtaacaa agagctccct gttctatgtc    120
 ctgattacct gtcttactac actaccattg aggagctcca gcagaagatc ttgtgtacca    180
 aggccgagaa ttccagactg gtctcgcaaa ttgacaacac caaactgact gcagatgact    240
 tgagagccaa atacgaagct gaggtgtctc tacgccagct ggtagagtca gatgccaatg    300
 gcctcaagca gatcctgaat gtgctgaccc tgggcaaggc cgacctagag gcacaagtcc    360
 agtctctgaa agaggagctc ctttgcctca agaacaacca caaagaggaa atcaattctt    420
 tacagtgtca gcttggggag agacttgaca ttgaagtgac tgctgcccct tctgctgacc    480
 taaaccaggt tctacaagaa atgagatgtc aatatgagcc catcatggag acaaaccgca    540
 aagatgtgga acagtggttc aacacgcag                                      569



      <210> 1793
      <211> 1653
      <212> DNA
      <213> Homo sapiens


      <400> 1793
 gcggccgccg cctccgctct gagccccgcc ccgctcggcc gccgattgct cgggcctggc     60
 cgccagcgcc aggggccgat ggccgagcgc gtcgcactcg cgtccctgcg ccgtgcctgc    120
 ctcgcgctcc ctgttacggc gttcgtcccc gggcctggcg cccgcgtccg gcccggctcc    180
 gcggcggcct ggtccgatgg ctcctcagcg gagggccgca accaaggcgc ccgagggcaa    240
 cggagcggcc gagcgccgga accggagcag caccaagaag gaccgagccc cgcgggaggt    300
 gcagaggctg tggcagaggc cgtggctaag gaccgcgggc ctgggggctg gctttgtgct    360
 caccgcactc ctgctctgga gcagcttggg ggccgacgac ggggtcgcag aggtcctggc    420
 ccgccgtggc gaggtcgtgg cagggagatt catcgaggtg ccctgctctg aggactacga    480
 cagtcaccgc aggttcgaag gctgcactcc ccgaaagtgc ggcagaggtg tcaccgatgt    540
 cgtcatcacc agggaggaag cggagcggat tcgcagcgta gctgaaaagg ggctctccct    600
 gggaggatct gacggagggg catccattct ggacttgcac tcaggggccc tgtctgtcgg    660
 gaagcacttt gtgaacctgt acagatactt cggggataaa atacagaaca tcttctcaga    720
 ggaggacttc cggttatacc gggaggtgcg gcagaaggtc cagctcacca ttgctgaggc    780
 ttttggcatc agcgcatcct cgctgcatct gaccaagccc accttcttct cccgcataaa    840
 cagcacggaa gcgcggacgg cgcacgacga gtactggcat gcgcacgtgg acaaggtgac    900
 ctacggctcc ttcgactaca cctcgctgct gtacctctcc aactacctgg aggacttcgg    960
 cggagggcgg ttcatgttca tggaggaggg tgccaacaag acggtggagc cgagagctgg   1020
 atgtttttgt ttccggatga tgtcttgtgg gttccaagaa gttaatggac cgagagccag   1080
 tgaagctgct ggtgcgaagg ctggagtcag gtgtcctccg gggactcacc acccgtccga   1140
 gaggggagag acacatgcga ttctggaagc tgagagcatt gcttattgtt gattccttgg   1200
 ttgccgtgct gagtcctgct ttaaggaagc aggtcgcgtc tccttcttca cctcggggtc   1260
 cgagaaccta caccgcgtgg agaaggtcca ctggggcacc cgttacgcca ttaccatcgc   1320
 cttcagctgc aaccccgacc atggcatcga ggacccagcg ttcccgtagc cagcagccgg   1380
 gccaaggtaa cttcaggagg gcccgtgtgg aggcagccgc gccagtcgtg cacccacccc   1440
 cacgtccacc cgctcctgtt gcacagagtg ccttaggaat tctctgattt tgatttgctg   1500
 acgtgttaat cttttcatct gtgagtaaat gaagggaacc agcttttcac ttctccagca   1560
 tcatgtgtgc ttgggctgta ggcctgggag cctgaggtgg aggccaggaa agggacccag   1620
 caggacgggg cacaagtccc catctgtgaa tgg                                1653



      <210> 1794
      <211> 454
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(454)
      <223> n = a,t,c or g


      <400> 1794
 tttttccttt gtgcaacact ttattgggaa agatttacac acggtgacct gtcataggcc     60
 aagcgatgag aagagggcgc caggagtgct ggggtcccga ggtggctcag atggaagcca    120
 tgggacggcc gtcccanggc ccgcgcaccc gcacctcagt ttcccctttg tgaaatggga    180
 agcttatgct tccttccaag tctgcaatat tggtgcgatg agctaaaagt ggagcnaaag    240
 acacaaggaa gaggcttccc actcccaggc tcaccagctt cagcgtcaca cgcaagctgg    300
 acggcattgg tgaagggcgt tgggagtggg caggcccagg aggctgaggg ctcggaagaa    360
 caggagatag gagaaagtcc aggccagagc cagggcgtgg caggagcagg gctgggcctg    420
 aatgagggcc aggtcccgag gatggtnacc agag                                454



      <210> 1795
      <211> 717
      <212> DNA
      <213> Homo sapiens


      <400> 1795
 tgaactgagc cacccagaga cttcaggcag aaatcaccaa cctcaggaaa cagatgggac     60
 cccaactcag cagtgtgctg ccctgcaaga caccatcctg gaggcagagc agaagggcaa    120
 ggtagccatc ggagatgccc aggacaagct ggctgaggtg gaggctggac cagctgctct    180
 gtgcggttcc tggagcagca gaaccaggtg ctggagacca agtgggagct gctacagcag    240
 ctggacctga acaactgcaa gaataacctg gagcccatcc ttgagggcta catcagcaac    300
 ctgcggaagc agctggagac gctgtctggg gacagggtga ggctggactc ggagctgagg    360
 agcgtgcggg acgtagtgga ggactacaaa aagaggtgag caggaggagt ccccctgtaa    420
 ctggacaact gcccttgtcc ctccaaggga cccctggcag tcaccccagc ttaaatgctt    480
 tggaggtcag tggagggcat tgttcttggt catatcaagc agaatcaccc caacaaaact    540
 ctggaacttg ctctctgctc ctccagcctc tggcctgact cttaggacaa atgcccagtg    600
 agctgggcag tgggcagagg gttatctctg gctctgggtt tagggaatgt ttggggaaac    660
 cactcacgtt ctcctcccat gtaagaggag ggttaagtgc atctggcttc aagactg       717



      <210> 1796
      <211> 561
      <212> DNA
      <213> Homo sapiens


      <400> 1796
 actattttct aaattctgtg ctaacagaac cggcttcagc tgaagaaaga gaggaatgaa     60
 gcgccttctg cttctggttt tgatctttat aacattttct tctgcatttc ccttagtccg    120
 gatgatggaa aatgaagaaa atgtgcaact ggctcagaat aataaactat actccggata    180
 tggcacgagc tgctgtggat gaggctatcc aagaaggttt agaagtgtgg agcaaagtca    240
 ctccactaaa attcaccaag atttcaaagg ggattgcaga catcatgatt gcctttagga    300
 ctcgagtcca tggtcggtgt cctcgctatt ttgatggtcc cttgggagtg cttggccatg    360
 cctttcctcc tggtccgggt ctgggtggtg acactcattt tgatgaggat gaaaactgga    420
 ccaaggatgg agcagatctc catgacaatt ctccctttta tggacatgat ggttgtcttg    480
 ctcatgcatt cccacctgga ccaggtatcg gaggagatgt tcattttgat aatgatgaaa    540
 caaggaccaa ggatttcaga a                                              561



      <210> 1797
      <211> 561
      <212> DNA
      <213> Homo sapiens


      <400> 1797
 actattttct aaattctgtg ctaacagaac cggcttcagc tgaagaaaga gaggaatgaa     60
 gcgccttctg cttctggttt tgatctttat aacattttct tctgcatttc ccttagtccg    120
 gatgatggaa aatgaagaaa atgtgcaact ggctcagaat aataaactat actccggata    180
 tggcacgagc tgctgtggat gaggctatcc aagaaggttt agaagtgtgg agcaaagtca    240
 ctccactaaa attcaccaag atttcaaagg ggattgcaga catcatgatt gcctttagga    300
 ctcgagtcca tggtcggtgt cctcgctatt ttgatggtcc cttgggagtg cttggccatg    360
 cctttcctcc tggtccgggt ctgggtggtg acactcattt tgatgaggat gaaaactgga    420
 ccaaggatgg agcagatctc catgacaatt ctccctttta tggacatgat ggttgtcttg    480
 ctcatgcatt cccacctgga ccaggtatcg gaggagatgt tcattttgat aatgatgaaa    540
 caaggaccaa ggatttcaga a                                              561



      <210> 1798
      <211> 1452
      <212> DNA
      <213> Homo sapiens


      <400> 1798
 atggcggagc tgcggcctag cggcgccccc ggccccaccg cgcccccggc ccctggcccg     60
 actgcccccc cggctttcgc ttcgctcttt cccccgggac tgcacgccat ctacggagag    120
 tgccgccgcc tttaccctga ccagccgaac ccgctccagg ttaccgctat cgtcaagtac    180
 tggttgggtg gcccagaccc cttggactat gttagcatgt acaggaatgt ggggagccct    240
 tctgctaaca tccccgagca ctggcactac atcagcttcg gcctgagtga tctctatggt    300
 gacaacagag tccatgagtt tacaggaaca gatggaccta gtggttttgg ctttgagttg    360
 acctttcgtc tgaagagaga aactggggag tctgccccac caacatggcc cgcagagtta    420
 atgcagggct tggcacgata cgtgttccag tcagagaaca ccttctgcag tggggaccat    480
 gtgtcctggc acagcccttt ggataacagt gagtcaagaa ttcagcacat gctgctgaca    540
 gaggacccac agatgcagcc cgtgcagaca ccctttgggg tagttacctt cctccagatc    600
 gttggtgtct gcactgaaga gctacactca gcccagcagt ggaacgggca gggcatcctg    660
 gagctgctgc ggacagtgcc tattgctggc ggcccctggc tgataactga catgcggagg    720
 ggagagacca tatttgagat cgatccacac ctgcaagaga gagttgacaa aggcatcgag    780
 acagatggct ccaacctgag tggtgtcagt gccaagtgtg cctgggatga cctgagccgg    840
 ccccccgagg atgacgagga cagccggagc atctgcatcg gcacacagcc ccggcgactc    900
 tctggcaaag acacagagca gatccgggag accctgagga gaggactcga gatcaacagc    960
 aaacctgtcc ttccaccaat caaccctcag cggcagaatg gcctcgccca cgaccgggcc   1020
 ccgagccgca aagacagcct ggaaagtgac agctccacgg ccatcattcc ccatgagctg   1080
 attcgcacgc ggcagcttga gagcgtacat ctgaaattca accaggagtc cggagccctc   1140
 attcctctct gcctaagggg caggctcctg catggacggc actttacata taaaagtatc   1200
 acaggtgaca tggccatcac gtttgtctcc acgggagtgg aaggcgcctt tgccactgag   1260
 gagcatcctt acgcggctca tggaccctgg ttacaaattc tgttgaccga agagtttgta   1320
 gagaaaatgt tggaggattt agaagatttg acttctccag aggaattcaa acttcccaaa   1380
 gagtacagct ggcctgaaaa gaagctgaag gtctccatcc tgcctgacgt ggtgttcgac   1440
 agtccgctac ac                                                       1452



      <210> 1799
      <211> 436
      <212> DNA
      <213> Homo sapiens


      <400> 1799
 gtcggaaaat ccgcgagccc cacgcgtccg gcttgaggac accttgacta acctccaagg     60
 gcaactaaag gatcaagaaa ggcccagcac agcagaagat cagctggatc tagctcctgc    120
 aggagatgtg tacaaagaca atcccagtcc tctggggatg tttcctcctg tggaatctct    180
 atgtctcatc ctctcagacc atttaccctg gaatcaaggc aaggattact cagagggcac    240
 ttgactatgg tgttcaagct ggaatgaaga tgattgagca aatgctaaaa gaaaagaaac    300
 tcccagattt aagcggttct gagtctcttg aatttctaaa agttgattat gtaaactaca    360
 atttttcaaa tataaaaatc agtgcctttt catttccaaa tacctcattg gcttttgtgc    420
 ctggagtggg aatcaa                                                    436



      <210> 1800
      <211> 1488
      <212> DNA
      <213> Homo sapiens


      <400> 1800
 ggccggggac gtaaaacttg gtcctctaaa acggcccccc cttttttttt tttttcaagt     60
 ttaaaagtca gaatatattt cactgaaaat atgtgtatgt gtgtgccttc aagagtgagt    120
 gctcctcaag ggagactcac acagttcctt acaacataaa taagaaatag acgtaatggc    180
 ttcactcagt agaaaactag cagcatcatt ctgggccatg gggcattccc caggggtcac    240
 catccagcag cctctccctg ggggcagagg acgcctggtc agaacagcta taactcatcc    300
 atcatggcga gcaaatcgtc ccctttgctg gtgctcagcc ttggctgctc cgtgatctca    360
 aactccccca tgattcgagc cagctcctcg ctccgttgct ggtcctgggt ggcttgtatg    420
 ttgataactt cataggataa ctcttctggc ctggttagcg ctgcttgttc ctcttcttca    480
 tcggtggtaa agagattcaa ccggaatccg ggctcagggc cactgggttt cttaatctcc    540
 atccctccca tcagcctggc caagaaattc agctcttctt tagcaagagg gtttggagca    600
 atgctttcct gggtccatga ggctaagttc tttgatgatc cagacacatg agtttccaca    660
 ggctgattca cgctgtacat gttagttccc agtttcagga ctcggtctcc ataaaattca    720
 aaagaacctt ctttgggtgc agggacatag tttcccccat gcttgaattc tatcctcttc    780
 acttcttcac ctttgttgtt gaacattctg atgagtcctg gaacttcagt tccccaagga    840
 acaggcccgg acaccggcaa cacaaagcga ccgttattat tctgaacttt gtcctttaga    900
 aacatggata ctcggatgtg caggtcttgg aagaagatga ggagtgtctg ccggatcagc    960
 tggaactccc ctgcagagag accaccatat atttctgtca gctgccgcaa agtctcgtcc   1020
 acttgctgca ggatggttgg ggagtctcgg atgaatccct tgatggtatc caagtgattg   1080
 aaagtgacca gcagcacatc cttgggtcgg ggacacagca atacttgata tttgaaagcc   1140
 atggtcatca ggtcatagag cttatccatg ctggcctggt tcagtttcat aatggaggca   1200
 tgagccaggc gctcatagac agtcctcagg gccttcttgg agtagagctc ttgaggcttg   1260
 aataattcct ccataaactt tctattgaac atggtggaga tgatgtcatt cagaactttg   1320
 cgggccttgt ctcccgggat gttctgggcc cgcagccgtt ggtcgaggat gtaaagcatc   1380
 tccccgccca agttcaagaa gagcagcggt agcgtccgca ccgacatggt gctggaaacg   1440
 agctggactg gtgaagagcc ccggggttcg gtagccagtg gcctgaag                1488



      <210> 1801
      <211> 1488
      <212> DNA
      <213> Homo sapiens


      <400> 1801
 ggccggggac gtaaaacttg gtcctctaaa acggcccccc cttttttttt tttttcaagt     60
 ttaaaagtca gaatatattt cactgaaaat atgtgtatgt gtgtgccttc aagagtgagt    120
 gctcctcaag ggagactcac acagttcctt acaacataaa taagaaatag acgtaatggc    180
 ttcactcagt agaaaactag cagcatcatt ctgggccatg gggcattccc caggggtcac    240
 catccagcag cctctccctg ggggcagagg acgcctggtc agaacagcta taactcatcc    300
 atcatggcga gcaaatcgtc ccctttgctg gtgctcagcc ttggctgctc cgtgatctca    360
 aactccccca tgattcgagc cagctcctcg ctccgttgct ggtcctgggt ggcttgtatg    420
 ttgataactt cataggataa ctcttctggc ctggttagcg ctgcttgttc ctcttcttca    480
 tcggtggtaa agagattcaa ccggaatccg ggctcagggc cactgggttt cttaatctcc    540
 atccctccca tcagcctggc caagaaattc agctcttctt tagcaagagg gtttggagca    600
 atgctttcct gggtccatga ggctaagttc tttgatgatc cagacacatg agtttccaca    660
 ggctgattca cgctgtacat gttagttccc agtttcagga ctcggtctcc ataaaattca    720
 aaagaacctt ctttgggtgc agggacatag tttcccccat gcttgaattc tatcctcttc    780
 acttcttcac ctttgttgtt gaacattctg atgagtcctg gaacttcagt tccccaagga    840
 acaggcccgg acaccggcaa cacaaagcga ccgttattat tctgaacttt gtcctttaga    900
 aacatggata ctcggatgtg caggtcttgg aagaagatga ggagtgtctg ccggatcagc    960
 tggaactccc ctgcagagag accaccatat atttctgtca gctgccgcaa agtctcgtcc   1020
 acttgctgca ggatggttgg ggagtctcgg atgaatccct tgatggtatc caagtgattg   1080
 aaagtgacca gcagcacatc cttgggtcgg ggacacagca atacttgata tttgaaagcc   1140
 atggtcatca ggtcatagag cttatccatg ctggcctggt tcagtttcat aatggaggca   1200
 tgagccaggc gctcatagac agtcctcagg gccttcttgg agtagagctc ttgaggcttg   1260
 aataattcct ccataaactt tctattgaac atggtggaga tgatgtcatt cagaactttg   1320
 cgggccttgt ctcccgggat gttctgggcc cgcagccgtt ggtcgaggat gtaaagcatc   1380
 tccccgccca agttcaagaa gagcagcggt agcgtccgca ccgacatggt gctggaaacg   1440
 agctggactg gtgaagagcc ccggggttcg gtagccagtg gcctgaag                1488



      <210> 1802
      <211> 4171
      <212> DNA
      <213> Homo sapiens


      <400> 1802
 ctagagtcga ttggcaggat gatacacctt aaaggcctga cagattggga attcctgctc     60
 tccataaagc ctgttggcaa tactcagtgt gtaatcagtc ttgatcctgt ctaatttgga    120
 gagaagctgc ccaaagtagc agctgaccag tccgctctca ttgtttaagg acccagcctt    180
 tttaacttgg atagtcacag gatcataccg aatgattcgc cctcccccag atggaggtgc    240
 ttgagtgtta aacaagagca gttcctggtg tgagtgggcc actataaaag agggaaggtg    300
 aaggtccgag aagtgagagg cgctggcaac aggaatggtg aagtggtaca gggtggcggt    360
 agcagctggg gtggacagga agaccatatg cagagtcacg gagggacctg tggttgggga    420
 cagagcagca cagcgtgatg gtctaagttt ccaaagggga gcattgaagg tgactttaac    480
 attgttgtag tcacatatag gagaatgtaa gagattatta tgaaacaatg tagtaaatgt    540
 acaataggga attctagata agcacagcag agaagcaacc agctcctttt caggtccttt    600
 cctgagactg attcggctgg aagggagtag gtcccgccaa atgaagaagc tttccgagac    660
 aacagcccca gtggctgcag ctgcctgggt accgttttca tccacctcca caaaggtttt    720
 gtggataatt tttgacaagt acaaattggg acttggagag attccagtaa gatcagccct    780
 cgtttcatca aagatatccg taatgcccat gtcttgtaaa atggaattga gatcatagct    840
 gtcttccagg gtgaaccggg ggaaggacag gaccaccgat tcttctgaca tgttttctga    900
 gctgctccag gccaccattt tttcataggt gattttcctt tcaagcgtca gcagcagcgg    960
 cgcaaccgcc tccccaatcc aggtcctgac cgttctgtcc gtcacttccc agatccgcgc   1020
 tttctctgtc cttcctgtgc gacggttacg ccgctccatg agcttatcgc gaataaatac   1080
 ctgtgacgga agatcacttc gcagaataaa taaatcctgg tgtccctgtt gataccggga   1140
 agccctgggc caacttttgg cgaaaatgag acgttgatcg gcacgtaaga ggttccaact   1200
 ttcaccataa tgaaataaga tcaatatgtt tattgcggca ttattcacaa tagcaaagac   1260
 tttggaacca acccaaaatg tccaacaatg atagactgga ttaagaaaag gggatcctct   1320
 agagtcgcat catccagctc gccaaccaga acacgataat cactttcggt aagtgcagca   1380
 gctttacgac ggcgactccc atcggcaatt tctatgacac cagatactct tcgaccgaac   1440
 gccggtgtct gttgaccagt cagtagaaaa gaagggatga gatcatccag tgcgtcctca   1500
 gtaagcagct cctggtcacg ttcattacct gaccataccc gagaggtctt ctcaacacta   1560
 tcaccccgga gcacttcaag agtaaacttc acatcccgac cacatacagg caaagtaatg   1620
 gcattaccgc gagccattac tcctacgcgc gcaattaacg aatccaccat cggggcagct   1680
 ggtgtcgata acgaagtatc agttgaagag cgttgatcaa tggcctgttc aaaaacagtt   1740
 ctcatccgga tctgaccttt accaacttca tccgtttcac gtacaacatt ttttagaacc   1800
 atgcttcccc aggcatcccg aatttgctcc tccatccacg gggactgaga gccattacta   1860
 ttgctgtatt tggtaagcaa aatacgtaca tcaggctcga accctttaag atcaacgttc   1920
 ttgagcagat cacgaagcat atcgaaaggg gatcctctag agtcgacctg gatgtccagg   1980
 cagaagtcta ctgcaggaat ggagccctta tgaaaaactt ctacaagggc agtgcagaag   2040
 gcaaacgtgg ggttggagcc ctcacacaaa gtgccacttg ggccactgcc tagtgaagct   2100
 gtgagagaag agccactgtg ctccagaccc cagaatggta gatctaccaa cagcttgcac   2160
 catatgcctg caggcatgca agcttcttga ccgggcagat atttccccgg gtgagaaaaa   2220
 agagcaacaa ctgatttagc caatttggcg gtgttgatcc agcggataat aatcttacgt   2280
 gaaatatttt ccgcatcagc cagcgccgaa atatttccag caaattcatt ctgcaatcgg   2340
 cttgcataac gctgaccacg ttcataagca cttgttgggc gataatcgtt acccaatctg   2400
 gataatgcag ccatctgctc atcatccagc tcgccaacca gaacacgata atcactttcg   2460
 gtaagtgcag cagctttacg acggcgactc ccatcggcaa tttctatgac accagatact   2520
 cttcgaccga acgccggtgt ctgttgacca gtcagtagaa aagaagggat gagatcatcc   2580
 agtgcgtcct cagtaagcag ctcctggtca cgttcattac ctgaccatac ccgagaggtc   2640
 ttctcaacac tatcaccccg gagcacttca agagtaaact tcacatcccg accacataca   2700
 ggcaaagtaa tggcattacc gcgagccatt actcctacgc gcgcaattaa cgaatccacc   2760
 atcggggcag ctggtgtcga taacgaagta tcttcaaccg gttgagtatt gagcgtatgt   2820
 tttggaataa caggcgcacg cttcattatc taatctccca gcgtggttta atcagacgat   2880
 cgaaaatttc attgcagaca ggttcccaaa tagaaagagc atttctccag gcaccagttg   2940
 aagagcgttg atcaatggcc tgttcaaaaa cagttctcat ccggatctga cctttaccaa   3000
 acttcatccg gtttacggac aacatttttt aaaaccatgc tttcccaggc catcccgaat   3060
 ttggctcctt catccacggt gactgagagc cattactatt gctgtatttg gtaagcaaaa   3120
 tacgtacatc aggctcgaac cctttaagat caacgttctt gagcagatca cgaagcatat   3180
 cgaaaaaccc agcttttttc tgctcatgaa ggttagatgc ctgctgctta agtaattcct   3240
 ctttatctgt aaaggctttt tgaagtgcat cacctgaccg ggcagatagt tcaccggggt   3300
 gagaaaaaag agcaacaact gatttaggca atttggcaag agttgataca gcgggggata   3360
 atcttacgtg aaatattttc cgcatcagcc agcgcagaaa tatttccagc aaattcattc   3420
 tgcaatcggc ttgcataacg ctgaccacgt tcataagcac ttgttgggcg ataatcgtta   3480
 cccaatctgg ataatgcagc catctgctca tcatccagct cgccaaccag aacacgataa   3540
 tcactttcgg taagtgcagc agctttacga cggcgactcc catcggcaat ttctatgaca   3600
 ccagatactc ttcgaccgaa cgccggtgtc tgttgaccag tcagtagaaa agaagggatg   3660
 agatcatcca atgcgtcctc cataagcagc tcctggtcac gttcattacc tgaccatacc   3720
 cgaaaagtct tctcaacact atcaaccccg agcacttcaa gaagtaaatt cacatcccga   3780
 acccgtgaaa tattttccgc atcagccagc gcagaaatat ttccagcaaa ttcattctgc   3840
 aatcggcttg cataacgtct tttctggggg tgagcacttg ttgggcgata atcgttaccc   3900
 aatctggata atgggggcat ctgctcatca tacagctcgc caaccagaac acgataatca   3960
 ctttcggtaa gtgcagcagc tttacgacgg cgacttccat cggcaatttc tatgacacca   4020
 gatactcttc tacccaacgc cggtgtctgt tgaccagtca gtagaaaaga agggatgaga   4080
 tcattcagtg cgttctcagt aagcagcttc tggtcacgtt cattacccga ccatacccga   4140
 gaggtgtttt taacactatc acccccgggc a                                  4171



      <210> 1803
      <211> 624
      <212> DNA
      <213> Homo sapiens


      <400> 1803
 ggagttaaag gtctactttg ctctttgtgc ttaagttaga tcaccgttca taatgtcata     60
 gttttctttt ttacaatctg tttcatgata ctcataaatt ttagagaaat ctgtctgaag    120
 gttctgcata cacctctgtg tgtttctggg gggtgtgtac ttttatacat cttagctctg    180
 acttgctgtt atacaaactc actcttaata tcgcatctcc ctcccctttc tctccccaca    240
 gaaacacaaa cacacttatt tatgtataga gtcctgaaag tcagaaagga cattaaaaac    300
 catgtattcc acccaactta cttggtagcc aaggaaacag aaacctatgg agaggagctg    360
 attcccctac ccccttgtag ggagcaccag gactaggccc tgggtgtcct gcttcaggtt    420
 cacagcttgg gatgcagagc ttgtccccag agcaggagct gcagggcctg ctctccaagc    480
 tgcctgcact ttctcagatg gatgtcaggt gccttccaat ctggagtacc tggaaatggg    540
 taacaatagt tgaacaagtg agtacagttg gcgaaaagct gagtctttct aaacagcttt    600
 ggaatgatta cagaggggac ttgc                                           624



      <210> 1804
      <211> 1493
      <212> DNA
      <213> Homo sapiens


      <400> 1804
 gcccatgact acgccaaact tggcacgagg cctgagtcct ttgagcacct gccacctctc     60
 ccagtatctc cttttccact acctgaatta gtagaggaaa ggggagacac acttcctccc    120
 cagaagcctg agctcaaagt gaaacgggtt ttcagaccca atggcattgc cctgacttgg    180
 aatataacca aaatcaatcc caagtgtgct cctgtagaaa agctaccacc tcttcctgtg    240
 tcatgagaac tctaataata agttgatttg gaagaagatt ggagaaatta aagctttacc    300
 actccccatg gcctgtactt tatctcagtt tttagcttcc aacagatact attttactgt    360
 ccaatcaaaa gatatttttg gacgatatgg accattctgt gatataaaat ctatccctgg    420
 gttttctgaa aatcttacgt aaaaggtgtt taataatgat atactacttt ttttttcata    480
 tttgtttgtt tgcaatgtta ctgtaatact atttgccatt gtaaaaggcc agctcagatt    540
 gtgagccctt tctattggga cagtcctctt ctatatgttt taagtggcca gtaatttaat    600
 gaatttctgg tttgtattaa atatgtcctt ccaatggata agttctaaaa catacgctat    660
 cattggccca tgttgctgag gtgcattgtg aacaatacct ttagtgactg tggaactgct    720
 gcttctatca gaagacctag gatacaagca gccactgttt cctccgttaa caatcagctt    780
 ttagtaacct gctgtggtca gcatagctac aggaaaagtc agcccttgac tgagggccag    840
 atcatccctg gagtgcacct ctactaagat tttatgaaaa gatgacatgt tgggctgcat    900
 gataaaagtt aattataaaa attaaaagat tttttttttg agatggaata ttgctctgtt    960
 gcccaggctg gagtacagtg gtcactgcaa cctccatctc cctggttcaa gcaattctcc   1020
 tatgtcagcc tcccaagtag ctgggactat agtcacttgc caccatgccc ggctaattta   1080
 tttttagtag agatgaggtt tcaccttgtt ggtcaggctg gtctcaaact cctgacctca   1140
 ggggatccac ccgcctcggc ctcccgaagt gctgggatta taggcgtaag ccaccatgcc   1200
 tggccaaaaa ttaaaagatt ttatgaaacg aaatggcttc ccattctttc tattcagctt   1260
 ctaagtgggc tattcatttg ggctctcctc tttttttgtt ttgttttgca cttttgttca   1320
 atcatttggg gaaatagcct ggaggtcttt cctgaatctg tttgtagaca taataaaatt   1380
 tgtgtgctgt gtacacaaaa acataatgta tcttatgaaa gcattaccca acctgtttga   1440
 gttgagaatg atttggccca ccttagattt gaggctttag ttggctgatt tcc          1493



      <210> 1805
      <211> 406
      <212> DNA
      <213> Homo sapiens


      <400> 1805
 tgttgggata tcataaactt ccctagaaat gtacatatat agagattgct attagccttg     60
 aacaaactgg aagatgtctt cctggcccag aatgttagcc cattgctttt atttacttaa    120
 agctttaagt tccagctacc taataaaaga aatgacaata atgccaggca ctctcctaag    180
 cactttatgt atactaactc acttaaatct cccaacacct ctgtgagata aatactactg    240
 ttattctcat tttacaggtg tcttctcagt agcagaagtg aattagttag aaaagttttt    300
 ttactttagc ttaacgtatt ccttcttatc cattccatta cttatttatt tcatcactgt    360
 ccttcttcca catttcttag ggctcttggg ttaggtgttc aatatg                   406



      <210> 1806
      <211> 369
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(369)
      <223> n = a,t,c or g


      <400> 1806
 agtatggnaa gcagaaatga gaccaaccaa taatccaatg tgatgccacc aatattaata     60
 tatgtgcaaa gtgctcagga ggcccaggta ttgggacact gactttacaa cgatggggca    120
 gaagtctgag aggtcctgtg tgaaggaaat aggtagaaac tagttcttcg aggaaacgac    180
 cccgagttgg ggtggtgcaa tggaaagcaa gtcctcttac tagggagttg tttgtttaca    240
 tctctagtgt ttgacccaca gagtcagctc ctgggttggg tttttgtttt ccagactttg    300
 gacaaagttt accaaatgaa aagcaaacct cggcgatcac tgtctgatca tcaacaatca    360
 caattatgc                                                            369



      <210> 1807
      <211> 5669
      <212> DNA
      <213> Homo sapiens


      <400> 1807
 tttttttttg ccagttgaag tatttggatt taactttacc caactaagac attcacacaa     60
 catatgcatg tcagtctcct gttcagtcct agagcctgca gtattgtaat ttattgtaaa    120
 accatgtaac caaatactta aatatatcca caacatctat accacagaaa tgcatagtac    180
 ataatatact aacatctcaa aataaacttc tattacagtt ttatgcaaat tatggtaaaa    240
 gattatcacc tgccacattt tgaaatggca ccaacttcaa catcaatgca ctagtcaaaa    300
 tccttactag aagtgatgtc ttctgcatta tcatctgaac attcaaaatc aagctgttaa    360
 tctaataacc acagtatgtt atcatttaaa atcactgtat atttggatgt taaagcaggt    420
 agtaatacag caggaaaagt gtttctaatt cacagtttca aaactaaagg gtgcagtttt    480
 caaatatctg attgcttaaa ttggtcactc aatttaacaa ctgcctcctt caatacatgt    540
 aaactatgtt tgcacagcat taggagatgt cttttatttc agaattagtt cttactgtta    600
 caggagcacc acaaatttta aggaagaggc tacagtgtga aatgagctca ctgaaggata    660
 tgttaaataa aattttaact acaatataag gtactgcaaa agctttgttc cccagcacag    720
 atcccttaat caggaaaagt agtgaacact tacccaatac aatatgtaaa ttcgctctac    780
 aggagatggg gaaaaaccta actcaactaa aagaaaatac tattattagc taacaaacct    840
 gtgatagctg gcttcagaat tttcctaaaa ataaaattca aaagcataca cagtatttat    900
 atcctttgat aaggaatgta gacatccaaa cggaatgaaa gaaaaatctg gttttaagaa    960
 tttctaagtg gaatcacaca cacacaaatg ggtaactgag aaaaactaaa tattcaaaat   1020
 ttaagtaaga agatttataa tagaaaaaag tggcaaattg ttactgtgac ttgattttct   1080
 gaaaacatct gcaaattcac actggcatta agaaaaccca agtctcaaaa attctccttt   1140
 ctttctctcc agataatgtg ttttctgtgc aaaaataaat atctgaaaat tgcactaata   1200
 cttattttaa cttctatatt atgaataatc tgcacatgct gctttacaga cgatacatat   1260
 ttgtaaactt actcatgcaa aattagtgtg cgcaacaggg atattgttaa ttttcatact   1320
 taaaaatgat accttattat cttttaaaaa ttgccaaact ctctgaaatg gttaacaaat   1380
 cttatatgga tattcttgtc tgccagctaa aaatcaattt atgttgctga aaacaaaaag   1440
 ttatacaaga aaaagaaaca tggtttttgt tttgcaagat ttttgatttt taaatgagaa   1500
 aatttataaa agaaagaaat tcatggtcac aaaattttaa cattttaatc ctaaacatta   1560
 cagggtaaat agatactgga ccctatctcc atactccata aaatcctaac ttttagtttc   1620
 catttcaaat gttgctgtaa ccactaaaac actagtggtt ttacaacctc tggattatgg   1680
 aaatacacat ttctgaaata aatgctacaa aaacaacaat ggaagaaagc caaacaaaca   1740
 gtctccatga aggaaaaaaa agtggaacat tttgaagctt ttagacactt ctctttccat   1800
 gtcttatgat taacctgtca attcagtgca ttgtatggtc atatgtaatg gtccccatgg   1860
 tgaacaaaca tctaactagt gtccattgat tccaagttag tagatgatga atctttctgg   1920
 atactttcaa agatagccgc cagctcaggg ttagaactga tctgtgactg gaattcactc   1980
 atcagtggac tcttctctgc ttctggaatg gttagtagtg ctgctactgc tctcatggca   2040
 gatcgcttta attcatcttg tttttcaaac tcctgcttta ctgagtttgc ctttacctta   2100
 gttgtacatg ttgcacgtaa tggctcaaca agtcggtcca acctctgcag tactgcactt   2160
 ggacaaaggg tagacagtct caccaacatt aaaaatgtca gcatcttaat atcataatgg   2220
 tccttcaaac catcttcaac atgatttaga aattcaaaga tatcaagtct atcaagacaa   2280
 ctgtctagaa gtgtgtacat acactcaaat gctgcctttc taatatccag accatcatca   2340
 accgtatgtt taaatggacc catttctacc tctcttataa gctcctttct aacttttgtt   2400
 tcattgtaaa gatgtggaag aacagtatcc aatagatccc ttattaatga tggcttgtta   2460
 tgtgctgctg aattaaatgt gaccaaggct actcttctca cattcaaatc tgggtcttcc   2520
 aaagttttta ggaaatcacc tatgcagttc tttaacagtg gatcaatagg ttgtggatgg   2580
 tcagaaattg taaatttcac agccgtaacc actgagcttc gggcatatga tgagcctgat   2640
 atcaagtacc ccttaagccg tggaaggaga gtttctggat caattagagt gagttttcct   2700
 agacattcag caacaacatt tctggttcct tcctctgcac actcacagtg ctttagtaat   2760
 aaggcccaga tgttttcaac atatggttta aggcccacca ctgatgcaga gctaataatt   2820
 tccttcaagg aatgaagtaa aagatactgc cttttgggtt gactagttat ttcttgcagg   2880
 acaaacggca gatattcagg aaggttgccc acactaatgc tgcctaatgc ataggatgca   2940
 gctgatttga cttcttcact aggagatgag aaagcttcta gtattacaga ttttagttcc   3000
 aactgtccac ttaagtcaat atgatgccca acttctccaa gagaaagtag agctaagaga   3060
 cgaatggaat ctgtagacct tgagttcttg acatcttgaa taaactgacc tactacagct   3120
 ggtccctctt tagggcatgc tcgagtaagg gcagctacac atttggcaat ggaataataa   3180
 gactgcttat gagtaagagc tgtgctctga gagtaaactg gaccagtcag catgcgcaac   3240
 aaatccatgt atcctaaatt atttgttcca gtgacaacca gagcttggaa aaagtctagc   3300
 atggcactaa gagctccccc ctgcaataag ggtgatctca caagtccaat aagttcattg   3360
 agaatggatc cacttatctt tgaaagggag gagggatata cttttgccaa agtggtaaga   3420
 aaactgatgg ccatttgtga aacatgcata tcactttcgc tgataagagg tgggagctca   3480
 tctagaactg catcaatcat ggcagctgtc aagctgtcac tatagttttt tattagaata   3540
 tcaagggcag aaagagtacc cagtttcaaa gctctctggt tttttctaag aaatgaagca   3600
 aggataggaa ccccttctcc cagaacaggc ctcaaatcta tcttcaaagg tgacccagca   3660
 atcagtgtca atgcctttac tgtagttaac ctggtaattt cattctttag tctctccaag   3720
 aaaatctgaa gtgtattagg caagtcagaa cccaaattgt ctccaaggtt gcaaataatt   3780
 tgtcccatac aggaaatagc cctttccttg acttcctgat caatgtcagc tgcttttaat   3840
 ctcttaatgg tacaggtaaa tagatctttg atataaggag ttgcatcaaa cgaggaaggc   3900
 tgatctaaag gacgaattac tttgacaagc tgttgagtaa caagaagtgc ttcagatgta   3960
 attttgtaaa atgggtctcc aacacaagcc accactggag gaaccaaagc ctgaacgtga   4020
 ggatggaaga cttgaggaga atggttacag aggattacgt atagacatga caaagcatcg   4080
 atcttcaaat tcgatgagct tgatttatca ttcagtgaga aaatgattcc tggtacaagt   4140
 acaggaatgt gttgagttag ggccccaggt aatacattta ccagctcagt taacatgtta   4200
 aaacaacact gtcgggtctt cacacttttt tctttcatct gtttgtgaag agctttaaca   4260
 atgttgggaa cctgactctg aagcattgtt aaaggtgttt ctccctgctc cattgcatca   4320
 gggtcacata gccaactttg tacaggacga gtttgcttca aaagagaaag gtatgcgtga   4380
 aaaacatctg cccttacatt ctcctcacgc tctttaaatc tggatattag tgcagggaga   4440
 gacggtcttg tagaattctg gaagcatttc atgccttgtg ctaactacag catccaagca   4500
 cttcgcagct gcacgtctca ctttccaact catgtcatca tcatcactgt attcatcatc   4560
 actcccttga tcatcatcat caccaccatc agcatccatt gcattttcat cttcatcttc   4620
 atcatcgtaa ttataatttg gatcataggt aagatattta agacaaatat ttataatggt   4680
 agaaacatga ggatatactt ccttaggaca tcttcttaca aatgattcaa aggcttgaat   4740
 acagtactct cttaattcat catcatctac attgcaaaat tttaccacca aaggaattat   4800
 cttctcaagg tattcaccta ttctatgacc agcttgccta ctaatagcag caatacattg   4860
 tatgtaggtt cttgttgttg acatagaatc atttttggac aactctgaca acagatgttc   4920
 aataagatct acaaaaacta tatttccaca gctcataacc agatggccaa gagcgataat   4980
 ggttcttttc ctcactgcaa gtctagggct ggtcaactgg ggaagtagac aggtcagaat   5040
 tgaaggatgg aaattaacaa gaagtcctcc ttgcctgctc aacatatcag ccataatatc   5100
 caaggcttct agctgaacag agacatcttc ctgttttgct attgcacttg taagacgtcc   5160
 agtaatcttt ttacatacat tagcagctaa tgcagagcca ctggaagctg gaggaagttc   5220
 tccaattact gttttaagac caatacttga aatgtctcga agttgttctt tatcagaaag   5280
 catgttagtg cagagggtat ctacaattgt ctctacttgg tattctttca ctttactcac   5340
 taaaggacca agacatttga cagctaaatt ctgtacctct ccatttttat cttccaataa   5400
 cttcaaaatc attttcacta ctttcctttc actatcatca tccaacttga tggaatcttt   5460
 ctgcagttcc gtcatcaaat catttgtagc cataaaccta aagtccttgt cgctggatgt   5520
 cattttttcc agcaaattgg aaatgtggta cgaggcgctc gccatgttga cggcctcgat   5580
 cccgcctgct ggcgctgctg gagctgctgc cccccgccgc tgccgccgcc gccgccgcca   5640
 ctgaagctcc tcctctcgct cgcggccgc                                     5669



      <210> 1808
      <211> 913
      <212> DNA
      <213> Homo sapiens


      <400> 1808
 acccacgcgt gcgctctgat tagcagcaga tttattattc tttcctcatt tcatgttata     60
 cttaataaaa caaaacatac ctgtatacac acacattcac tcacattgaa gatgcaagat    120
 gaagaaagat acatgacatt gaatgtacag tcaaagaaaa ggagttctgc ccaaacatct    180
 caacttacat ttaaagatta ttcagtgacg ttgcattggt ataaaatctt actgggaata    240
 tctggaaccg tgaatggtat tctcactttg actttgatct ccttgatcct gttggtttct    300
 cagggagtat tgctaaaatg ccaaaaagga agttgttcaa atgccactca gtatgaggac    360
 actggagatc taaaagtgaa taatggcaca agaagaaata taagtaataa ggacctttgt    420
 gcttcgagat ctgcagacca gacagtacta tgccaatcag aatggctcaa ataccaaggg    480
 aagtgttatt ggttctctaa tgagatgaaa agctggagtg acagttatgt gtattgtttg    540
 gaaagaaaat ctcatctact aatcatacat gaccaacttg aaatgtccct cgtccacatt    600
 ttaggctttt atacagaaaa acctaagaca attaaactac gtatggattg ggcttaactt    660
 tacctccttg aaaatgacat ggacttgggt ggatggttct ccaatagatt caaagatatt    720
 cttcataaag ggaccagcta aagaaaacag ctgtgctgcc attaaggaaa gcaaaatttt    780
 ctctgaaacc tgcagcagtg ttttcaaatg gatttgtcag tattagagtt tgacaaaatt    840
 cacagtgaaa taatcaatga tcactatttt tggcctatta gtttctaata ttaatctcca    900
 ggtgtaagat ttt                                                       913



      <210> 1809
      <211> 419
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(419)
      <223> n = a,t,c or g


      <400> 1809
 tttcnccccg aatnnaaggt cgacccacgc gtccgccttt gggttatctt ctctattaag     60
 tgtggatccc tgaaaaatgg cataccctgg tggtttttct agcccctgct gaaatccttt    120
 gaaggaatgt acttatttgt caagattcgt ctaaaaatgt ggtctccaga aatgaacata    180
 gatgtgctgt gagctccttg cagttgtgat tgcgacactg ataattaaga ttggtttagt    240
 tgttctgttg tacttcatca aattgttgat tcacattgaa tttatcaaac gtcattctat    300
 tctaaaatgt gaaagtattt ttaacttaaa tgtaggaatt cgcatgtatc caggacaagt    360
 aaatttttgt gaaacattgc agatgttaga tggatttggg agaattttcc aaactaagt     419



      <210> 1810
      <211> 352
      <212> DNA
      <213> Homo sapiens


      <400> 1810
 aaagaggctt cttgattgtg ctgttcattg ttgtaaatcc atggagctgt gcaacagtga     60
 gtaactccag atgtcctccc tccctactgc agcccctgcc cttgatgtgg actggcagag    120
 cagcacgacc tttgcctcct gtagcacaga catgtgtatc catgtgtgca ggctcggctg    180
 tgaccgccca gtcaaaacct tccagggaca cacagtaagt gagagctctt gtcactggtc    240
 tcgagtttgt gagaatgtga tgtgggagcc gattcttgtg tgcctagaat taaaagctac    300
 tgcagcagca gaccagctct aatgtgcccc ttggctattt gagctgtcat gg            352



      <210> 1811
      <211> 1783
      <212> DNA
      <213> Homo sapiens


      <400> 1811
 ccgggtcgac gatttcgtct tcgtcgtcgg gggcctcgct gtaattctgt tcccattgtg     60
 cccctacttc aagtactccg tcatgatcaa caaggccacg ccctacaact acccagtgcc    120
 cgtccgtgat gatgggaaca tgcccgacgt gcccagccac ccccaggacc ctcagggccc    180
 cagcctggag tggctgaaga aactgtgagc acctccactg acagaggcgg cccctcccac    240
 ggctcccaat aaaaatgtga aaaccaaccc ccgaacgtga gcatgtgtgt gatcagaggt    300
 gggaacaagt agacggtggc cggggtgagt gtggggtcag tttattgggc atgcgtcagt    360
 caaaggctgg gctggccagg gtcgggtagg gcagcagttt gtctggaccc cgagaaaccc    420
 aactggaatc cagggcctca tctgcttcaa agccaaagtc ttcctcaacc ttaatctgca    480
 ccggggccag ctctggagtc agcgcatttc ctgctgggcg tccatcccgt ggcactcgcc    540
 gcctcttccg cccactgggc ccctcaccgg gggctgggac tgccgggttt ctgggggtgc    600
 aggagtcctt ctgggcgggg acagtgtctc tttctctgga ggctcattct ccgcattgcc    660
 tggggtgggg gcatccgtgc cctggctgcc ctcatcctgg caggcaggag ggggaggtag    720
 gtgatgggtg ggtcctgagc tcccagttcc tgaccctcct ggaggcccaa cactcacctc    780
 cagcacaatg gtgaactggc tggcccggta gtcatccccg taggagtcca gcactctcat    840
 gaggaacctg ctcaggggga gaagccacca acggaataac ttatctccta gcggctgggg    900
 aaaagggcca caggatagag ctcagctccc actccactca acgccaaagc tgtcctggag    960
 ccagacggtc ctgagctctg gcactggagg cctgggagcc atgcccttga ccagccttga   1020
 gacctcgagc aagacaaggc aaccattctg aggctgagtt tcctgctctg caaacgacat   1080
 gacaccctcg gctggatgtt gcagcggtga cactgaagta gtgacaccag acgatttctg   1140
 tacttaatgt gatgtcagca cttagtaaac attcatatgt gagttataat ttttattgat   1200
 aactgaagag aggggagtac agaacgctcc tcctaatgac ctcacctctt ataaacaccc   1260
 ccttctcttt tttccccagc ccctgcctcc agagttcctt aaggttcaat tgatggaatg   1320
 cctcctctgc accagcacct gggcaggttt gttgttgttg ttttgcgacg gagtcttact   1380
 ctgtcaccca ggctggagtg cagtggcatg atattggctc accacaacct ccacctccca   1440
 ggttcaagcg attctcctgc ctcagcctcc tgagtagctg ggattacagg tgcccgccac   1500
 cacacccagc taatttttgt atatttagta gagacagggt ttcaccattt gggccaggct   1560
 ggtcttgaac tcctgacctt gtgatccacc cacctcggcc tcccaaagtg ctgggattac   1620
 aggcgtgagc caccgcgccc ggcctattat gcttttaaga ctcagaagta tctggccact   1680
 actgatgttt acaaagtagg aaatttagcc tgtagttcca gctactccag aggctgaggg   1740
 ggtaagatca cataagccca agaggctgca gtgaggtacg att                     1783



      <210> 1812
      <211> 1783
      <212> DNA
      <213> Homo sapiens


      <400> 1812
 ccgggtcgac gatttcgtct tcgtcgtcgg gggcctcgct gtaattctgt tcccattgtg     60
 cccctacttc aagtactccg tcatgatcaa caaggccacg ccctacaact acccagtgcc    120
 cgtccgtgat gatgggaaca tgcccgacgt gcccagccac ccccaggacc ctcagggccc    180
 cagcctggag tggctgaaga aactgtgagc acctccactg acagaggcgg cccctcccac    240
 ggctcccaat aaaaatgtga aaaccaaccc ccgaacgtga gcatgtgtgt gatcagaggt    300
 gggaacaagt agacggtggc cggggtgagt gtggggtcag tttattgggc atgcgtcagt    360
 caaaggctgg gctggccagg gtcgggtagg gcagcagttt gtctggaccc cgagaaaccc    420
 aactggaatc cagggcctca tctgcttcaa agccaaagtc ttcctcaacc ttaatctgca    480
 ccggggccag ctctggagtc agcgcatttc ctgctgggcg tccatcccgt ggcactcgcc    540
 gcctcttccg cccactgggc ccctcaccgg gggctgggac tgccgggttt ctgggggtgc    600
 aggagtcctt ctgggcgggg acagtgtctc tttctctgga ggctcattct ccgcattgcc    660
 tggggtgggg gcatccgtgc cctggctgcc ctcatcctgg caggcaggag ggggaggtag    720
 gtgatgggtg ggtcctgagc tcccagttcc tgaccctcct ggaggcccaa cactcacctc    780
 cagcacaatg gtgaactggc tggcccggta gtcatccccg taggagtcca gcactctcat    840
 gaggaacctg ctcaggggga gaagccacca acggaataac ttatctccta gcggctgggg    900
 aaaagggcca caggatagag ctcagctccc actccactca acgccaaagc tgtcctggag    960
 ccagacggtc ctgagctctg gcactggagg cctgggagcc atgcccttga ccagccttga   1020
 gacctcgagc aagacaaggc aaccattctg aggctgagtt tcctgctctg caaacgacat   1080
 gacaccctcg gctggatgtt gcagcggtga cactgaagta gtgacaccag acgatttctg   1140
 tacttaatgt gatgtcagca cttagtaaac attcatatgt gagttataat ttttattgat   1200
 aactgaagag aggggagtac agaacgctcc tcctaatgac ctcacctctt ataaacaccc   1260
 ccttctcttt tttccccagc ccctgcctcc agagttcctt aaggttcaat tgatggaatg   1320
 cctcctctgc accagcacct gggcaggttt gttgttgttg ttttgcgacg gagtcttact   1380
 ctgtcaccca ggctggagtg cagtggcatg atattggctc accacaacct ccacctccca   1440
 ggttcaagcg attctcctgc ctcagcctcc tgagtagctg ggattacagg tgcccgccac   1500
 cacacccagc taatttttgt atatttagta gagacagggt ttcaccattt gggccaggct   1560
 ggtcttgaac tcctgacctt gtgatccacc cacctcggcc tcccaaagtg ctgggattac   1620
 aggcgtgagc caccgcgccc ggcctattat gcttttaaga ctcagaagta tctggccact   1680
 actgatgttt acaaagtagg aaatttagcc tgtagttcca gctactccag aggctgaggg   1740
 ggtaagatca cataagccca agaggctgca gtgaggtacg att                     1783



      <210> 1813
      <211> 1783
      <212> DNA
      <213> Homo sapiens


      <400> 1813
 ccgggtcgac gatttcgtct tcgtcgtcgg gggcctcgct gtaattctgt tcccattgtg     60
 cccctacttc aagtactccg tcatgatcaa caaggccacg ccctacaact acccagtgcc    120
 cgtccgtgat gatgggaaca tgcccgacgt gcccagccac ccccaggacc ctcagggccc    180
 cagcctggag tggctgaaga aactgtgagc acctccactg acagaggcgg cccctcccac    240
 ggctcccaat aaaaatgtga aaaccaaccc ccgaacgtga gcatgtgtgt gatcagaggt    300
 gggaacaagt agacggtggc cggggtgagt gtggggtcag tttattgggc atgcgtcagt    360
 caaaggctgg gctggccagg gtcgggtagg gcagcagttt gtctggaccc cgagaaaccc    420
 aactggaatc cagggcctca tctgcttcaa agccaaagtc ttcctcaacc ttaatctgca    480
 ccggggccag ctctggagtc agcgcatttc ctgctgggcg tccatcccgt ggcactcgcc    540
 gcctcttccg cccactgggc ccctcaccgg gggctgggac tgccgggttt ctgggggtgc    600
 aggagtcctt ctgggcgggg acagtgtctc tttctctgga ggctcattct ccgcattgcc    660
 tggggtgggg gcatccgtgc cctggctgcc ctcatcctgg caggcaggag ggggaggtag    720
 gtgatgggtg ggtcctgagc tcccagttcc tgaccctcct ggaggcccaa cactcacctc    780
 cagcacaatg gtgaactggc tggcccggta gtcatccccg taggagtcca gcactctcat    840
 gaggaacctg ctcaggggga gaagccacca acggaataac ttatctccta gcggctgggg    900
 aaaagggcca caggatagag ctcagctccc actccactca acgccaaagc tgtcctggag    960
 ccagacggtc ctgagctctg gcactggagg cctgggagcc atgcccttga ccagccttga   1020
 gacctcgagc aagacaaggc aaccattctg aggctgagtt tcctgctctg caaacgacat   1080
 gacaccctcg gctggatgtt gcagcggtga cactgaagta gtgacaccag acgatttctg   1140
 tacttaatgt gatgtcagca cttagtaaac attcatatgt gagttataat ttttattgat   1200
 aactgaagag aggggagtac agaacgctcc tcctaatgac ctcacctctt ataaacaccc   1260
 ccttctcttt tttccccagc ccctgcctcc agagttcctt aaggttcaat tgatggaatg   1320
 cctcctctgc accagcacct gggcaggttt gttgttgttg ttttgcgacg gagtcttact   1380
 ctgtcaccca ggctggagtg cagtggcatg atattggctc accacaacct ccacctccca   1440
 ggttcaagcg attctcctgc ctcagcctcc tgagtagctg ggattacagg tgcccgccac   1500
 cacacccagc taatttttgt atatttagta gagacagggt ttcaccattt gggccaggct   1560
 ggtcttgaac tcctgacctt gtgatccacc cacctcggcc tcccaaagtg ctgggattac   1620
 aggcgtgagc caccgcgccc ggcctattat gcttttaaga ctcagaagta tctggccact   1680
 actgatgttt acaaagtagg aaatttagcc tgtagttcca gctactccag aggctgaggg   1740
 ggtaagatca cataagccca agaggctgca gtgaggtacg att                     1783



      <210> 1814
      <211> 1968
      <212> DNA
      <213> Homo sapiens


      <400> 1814
 tttcgtatta aggtatttta agacagaaag agagagagga gagaaaccgc attcataaaa     60
 aagaaatcct ctttttagaa catctcttgg tggtaccatc agaaatgtct tccttaagtg    120
 gaaaagtcca aaccgttttg ggccttgtag agccaagcaa actgggccgt accctgaccc    180
 atgaacacct ggccatgacc tttgactgct gttactgtcc acctcccccg tgccaggaag    240
 ctatttccaa agaacctatc gtgatgaaaa atttatattg gattcagaaa aacgcctatt    300
 cccataaaga aaaccttcaa ttaaatcagg agacagaagc cataaaggaa gaactgttgt    360
 attttaaagc taatggtgga ggggctttgg tggaaaacac aaccactggg attagccgag    420
 acacacagac gttgaagagg cttgcagaag agactggcgt ccatatcata tctggagccg    480
 ggttttatgt ggatgcaact cactcctcag agaccagggc catgtcagtg gagcagctta    540
 ccgatgtcct tatgaatgaa attctccatg gagctgatgg aaccagtatc aagtgtggca    600
 ttattggaga aattggttgc tcctggcctt tgactgagag tgaaagaaag gttctccagg    660
 ccacagctca tgcccaggct cagcttggtt gtcctgttat tatccatcct ggacggagct    720
 ccagggcacc atttcagatt atccgaatat tgcaagaagc aggcgcagac atctccaaaa    780
 cagtcatgtc acacctggat aggactattc ttgataagaa agagctcttg gagtttgctc    840
 aacttggctg ctacttggaa tatgatctct ttggtactga actacttcat taccaactcg    900
 gcccagatat tgacatgcct gatgataaca aaagaattag aagggtgcgt ctcctggtgg    960
 aagagggctg tgaagatcga attctggtag cacatgacat acatacgaaa acccggctga   1020
 tgaaatatgg aggtcacggc tattctcata tactcaccaa tgttgttcct aaaatgttgc   1080
 tgagaggcat aactgagaat gtgcttgata agattctaat agagaaccct aagcaatggc   1140
 taactttcaa ataggatggt tgcttatgaa ttcacacctt gagtataaaa cttgcagaga   1200
 acattcagcg atttccagtc cactgtgaga tattaatcag ttacctagga ctaatgacag   1260
 atcatttcct tctgatgaga actaggaggg tttgccttct ctgagaccag ctattacaac   1320
 tgtgcctcta gggagttact cagcctaatt gagccctatt attttaactt aacaaaataa   1380
 atacagaagt acctatttct aaacaatgat ttaaagtcta tatcccctaa gcggagttgt   1440
 tgtttttctc cctaatctat cagctgcact acttgagaaa atttaaagtg tttctagtta   1500
 aattatttcc ttcttgagcg atctaatgtt tcttgtaata ttgatgatcc tactaattat   1560
 cctgctgttc tttaattaat gcttaatgaa taatatggca gtgtaaaata gcttctgcaa   1620
 caagggaagt taaattttga gacttttttc cccaaaggat actgactgta atacaattac   1680
 caattcacaa tgataaaaat attttgaaag gttaatttta tactgtccac ctatctatat   1740
 attcttctac tgaaatgatt ttgatatctt tggctttccg gtatctattt ttgccataca   1800
 ttttgctgtt ttgcaaagtt tgtataagaa cacataacac tactgaatta taaaaactca   1860
 atcataaaag tcaaaatata ttacataata tagtttaatg aatcattaca tttataataa   1920
 caaaggccac aatttaatta attggtaaga tataatgcaa aaaaaaaa                1968



      <210> 1815
      <211> 920
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(920)
      <223> n = a,t,c or g


      <400> 1815
 ttttattttt tttttctgct ttaatgttaa aaatatttat tttttttcct aaaagatcac     60
 acaaaagttg ggaagagaag gatgtcaatt agactacatc aaaatctggg cagagggagg    120
 acaaagagct gcctaaagaa actggtagct ggagcaaact gcagagatca agatgaccct    180
 agtccacgga accagcagcc caggtcagcc acattcagga gcaccaccga ggcacggcag    240
 ggagagcaaa gttgctggcc ccaatcattc ctccttttca gggcaggaga ggcagaagct    300
 cactctttag acatgttctt gatggtcttg tgctctttca tggccttctc ccaatcgctg    360
 ccattgaatt cctcagtgac catactccgc acagtgccct catccaggca gtggggggca    420
 attccgaagc ctccggggtt tgatcgtgga gtatagaagc tctgaacgcc acatctctta    480
 cagaaggtat gctgggcttt gtgagtattg aacgtgtaag tcgttatgtg ctcagctccc    540
 ttcaggagct tgaagcgaga agctggaaca atgaagtgtc tattctgctt cttcttgcaa    600
 atgctgcaac tacagaaaga cagagcaaat tccagattgt gagcagccac ctgcatcctc    660
 tatgcctgag cggcccagcc atgagagcca gccgacccca cagatgatgc ccctttcagc    720
 accatccagg gccgaggagc tggggcaaag gcctggatag cagtgcctct ggtttgcagg    780
 tacagcagag cccagggggg tcccaagtca gcagtcgagg ttctgcaatg ctcagaacac    840
 aggaccaaca gacaggtctg tactgcccac ccctcagttc gaattccacc acactgacta    900
 ggggnctacg agtcttctat                                                920



      <210> 1816
      <211> 2873
      <212> DNA
      <213> Homo sapiens


      <400> 1816
 tcctgccgcg ccggcagcca caggctggca tagcggctgc cgacccgccc tcgttcctcc     60
 accccctgca cgggactgct gggcccgccc cgccccgcct gcaggtgaag cggccgcagc    120
 cgccgagtag gtgcgtgggg atgatctcac tcgcgcgctc cgcgccagga ggaggaggag    180
 cgggagcgga tccaacttcc gggtagtgga gccgcaagcc accggcatct tgctttttct    240
 tccccctcct cctgtgtgcc ccgcgccgct ccctctttcc cttttattcc cggccccacc    300
 cgccaaaatg aacagctcgg acgaagagaa gcagctgcag ctcattacca gtctgaagga    360
 gcaagcaata ggcgaatatg aagaccttag agcagagaac cagaaaacaa aggagaagtg    420
 tgacaaaatt aggcaagaac gagatgaagc cgttaaaaaa ctggaagaat ttcagaaaat    480
 ttctcacatg gtcatagagg aagttaattt catgcagaac catcttgaaa tagagaagac    540
 ttgtcgagaa agtgctgaag ctttggcaac aaagctaaat aaagaaaata aaacgttgaa    600
 aagaatcagc atgttgtaca tggccaagct gggaccagat gtaataactg aagagataaa    660
 cattgatgat gaagattcga ctacagacac agacggtgcc gccgagactt gtgtctcagt    720
 acagtgtcag aagcaaatta aagaacttcg agatcaaatt gtatctgttc aggaggaaaa    780
 gaagatttta gccattgagc tggaaaatct caagagcaaa ctcgtagaag taattgaaga    840
 agtaaataaa gttaaacaag aaaagactgt tttaaattca gaagttcttg aacagagaaa    900
 agtcttagaa aaatgcaata gagtgtccat gttagctgta gaagagtatg aggagatgca    960
 agtaaacctg gagctggaga aggaccttcg aaagaaagca gagtcatttg cacaagagat   1020
 gttcattgag caaaacaagc taaagagaca aagccacctt ctgctgcaga gctccatccc   1080
 tgatcagcag cttttgaaag ctttagacga aaatgcaaaa ctcacccagc aacttgaaga   1140
 agagagaatt cagcatcaac aaaaggtcaa agaattagaa gagcaactag aaaatgaaac   1200
 actccacaaa gaaatacaca acctcaaaca gcaactggag cttctagagg aagataaaaa   1260
 ggaattggaa ttgaaatatc agaattctga agagaaagcc agaaatttaa agcactctgt   1320
 tgatgaactc cagaaacgag tgaaccagtc tgagaattca gtacctccac cacctcctcc   1380
 tccaccacca cttccccctc cacctcccaa tcctatccga tccctcatgt ccatgatccg   1440
 gaaacgatcc caccccagtg gcagtggtgc taagaaagaa aaggcaactc aaccagaaac   1500
 aactgaagaa gtcacagatc taaagaggca agcagttgaa gagatgatgg atagaattaa   1560
 aaagggagtt catcttagac ccgttaatca gacagccaga ccgaagacaa agccagaatc   1620
 ttcgaaaggc tgcgaaagtg cagtggatga actaaaagga atactggcct cccagtagca   1680
 ttggatgcag gaaaaaatac attgacggtg aaaaacaagc cgaaccagtt gtagttttag   1740
 atcctgtttc tacacatgaa ccccaaacca aagaccaggt tgctgaaaaa gatccaactc   1800
 aacacaagga ggatgaaggc gaaattcaac cagaaaacaa agaagacagc attgaaaacg   1860
 tgagagagac agacagctcc aactgctgat ccataaacca gaagcctgac atgtttggaa   1920
 gtccttttca ataagcacat gattagtgtt gttatattgg caagggctgt aaacattctg   1980
 ctctggtcac tgtattcaga atacaggttc ttttctggtg tcacttttgt aagtagcaac   2040
 tataaacata agtaagctgt ttagcaaaac acacattcct agtaggtttt ggttttttga   2100
 tctttataaa gatgaggttt ttttcctagt tactgtatta agtatgactt cttttagaag   2160
 gttacaaaaa aattcagatg ttgatacctt tttaggaaat gtgcatacca ctcatcaaat   2220
 ggaatgctga aagtttgagg tgcttgtata taatcggata aacaaaactg atcaacccaa   2280
 tgtgatttta aaagccccca aagaagcttc tgttttgggt ctgatcctct tgatggagaa   2340
 actgcagcag catggaaatt gttgggtact gtggcataca agttattttc tacagtagac   2400
 tgagataaac tgaaaactca ggagctggca tcaaactcgt agtcccatag tcagtgttaa   2460
 ttacacacat tgttaactat tggatgaaaa atacatgcta ttgattgtgt ccaaagcctc   2520
 ccgaggacct ccgtggggat gctctggtag cctgaataca gaactgaggt gaaagtccaa   2580
 accttgaatt ttacagtagt aagttggtaa accatgtgct ctgtgctatg agttaattat   2640
 gttttcccaa atactaatgt ggcacaagta ccatatttta tcagagttct tatgtacagt   2700
 atggtgaaga taagtgacaa gcacacattt ttcttgcttc actgctgttc tatattacac   2760
 aggtttgttg ttgttttttt taaaaaagaa attaagcagt agttagtctc taaaaataca   2820
 atgtttcagg ctaccacagt gaataaatag aaatgtaatc agggattaaa aaa          2873



      <210> 1817
      <211> 1296
      <212> DNA
      <213> Homo sapiens


      <400> 1817
 agagagaccc ttccagctcc ccttgttagc ccaggaagcc cagggaccag tgggtccccc     60
 cgaaagcccc tgtgcttgca gcagtgtcca ccccagtgtc taacagtcct cccgggctgc    120
 cagccctgac tgtcgggccc ccaagtggtc acctccccgt gtatgaaaag gccttcagcc    180
 ctgactgctt cctgacactc cctccttggc ctccctgtgg tgccaatccc agcatgtgct    240
 gattctacag caggcagaaa tgctggtccc cggtgccccg gaggaatctt accaagtgcc    300
 atcatccttc acctcagcag ccccaaaggg ctacatccta cagcacagct cccctgacaa    360
 agtgagggag ggcacgtgtc cctgtgacag ccaggataaa acatccctca aggctgggtg    420
 tggaggctca cgcctgtaat ctcagcattt tgggaggcca agtgcggaca tcacttgaga    480
 ccaggagttc caaaccagcc ctggcaacat tgtgagaccc atctctataa aaacaaaaaa    540
 cagtccacta aatcagccac attaattggg aatcatatgt cacaggtcat ttgtggggca    600
 aacatcactg cttttccatc aagggagcaa agaataagtg ggagttttgg aagagtttgg    660
 atgagagacg ccaaggtgcc cagcgttcgt aaggcaacat gcagcctggc gtgaagcagt    720
 attttgaaac tgcaaatggt tcccttcttg tgtcctttca atgctgaata ttttagtgtc    780
 attctgcctg tgctcagagc tccagcagca gaagtgtgtg tggttaatta ggacacttct    840
 gtgagaggac ccctgcacac attacgacag gtccctaaat gagcatttcc caaactaggt    900
 tccccgaggc actctacgga aacaagattt ttttttttga gacggagtct cggtctgtca    960
 cccaggctgg agtgcagggg tgcaatcttg gggcaatctt ggctcagggc aatccgcctc   1020
 ccaggttcaa gcgattctcc cgcctcagta gctgggatta caggggccca ccactgcgcc   1080
 cagctaaatt ttgtattttt agtagagagg gggcttcacc atgttggcca ggctggtctg   1140
 gaactcctga ccttcaggtg atccacctgc ctctgcctcc caaagtgctg ggattacagg   1200
 cgtgagccac cgtgcccggc ccaaactact ttttaaaaca gctacagggt aaaatcctgc   1260
 agcacccact ctggaaaata ctgctcttaa ttttct                             1296



      <210> 1818
      <211> 838
      <212> DNA
      <213> Homo sapiens


      <400> 1818
 gtcatcccca attttaatag cctgcttttt aaaaggtaat gcctgtgaaa tgggtttgtc     60
 acattttcta tgttctgttc ctttccattg ctcattttgc aagtgtatcc tacttggaaa    120
 aaccctaatt ggcatctaac ttttcacacg agtgtgtttt cttttcccaa aggggttaga    180
 agtttggctc ggggaatccc tgaccatctc cacagtgcct agcacggagt gaacatttac    240
 tgaatactgc tagcccattt gtagcagcat ggtcccctgc cctgtggatt acctcctgtt    300
 catgccctgg ctggtctggc catgtctgga gcacctgtgt ggttatgaga accttggcaa    360
 atgaaggacc aggagcagga gagctcttat gagatgaagt tgaaggacta gaggctgaac    420
 tactggggag ggaccaaatg ggatttggga ctaatctgtc acatggggag tgtaggcatc    480
 caggtaaaag tggcagcctg aacacatgca gtttttgttt ttgtttgctc catccccaag    540
 ccccactgaa tgaacagcaa agaggctggg cgcagtggcc catgccctga atccccagcg    600
 ctttgggagg ccgaggtggg tggaccacct gcaggcagga gatcgagaac cgcctggtca    660
 agatggtgca acccccgttt ctactccact accataatct cacccggggg ccggcggcca    720
 cgcctccacc ccctagccac ctttccccgc ctgcggtgcc caacaatcct tctcccccct    780
 ccaacacccg tttgccactt gtcctttaca cccccctcgt ccgaccccac ttctcccg      838



      <210> 1819
      <211> 845
      <212> DNA
      <213> Homo sapiens


      <400> 1819
 gtcgtggaat tccactgtgt ctccaccaca tttttttgtg ccctgggtct gctcatggga     60
 ggcagcgtta ggaaggaggc ggcctcactt ttttctgcct tccctttatc ctgggctttt    120
 tagttccttg gttcccctcc cccctttcca ttccattcat agatgcagca gatgatgtgg    180
 gcggggctgc tgtgcccaca gttggagtgg ctgcagggga gggcatgcag gccgtgcggc    240
 cttctggctt cagatgctgc tgccctgtgg ttccgtggtg gcatttctgc ctgggaggac    300
 tcctgtgcag ttagcaacat aagacatgaa gcatataatt gtcacttgtc agtcttttta    360
 aatcgctgtg caaatgaatt aacagttcag tttcttataa ttttagcttt ccaaatcatg    420
 ctttcctgtg ctgtgatagc tcctgcagtc cccgttttcc agagactgac tctcaagagg    480
 tctggaagga ccagcctggg cagcacaggg aggctccatt tctgcaaata ataaaacgag    540
 ttagctgggc gtactggcgc acacctgtgg tcccagctac ttgggaggct gaggggggag    600
 gatcacttga gcccaggagt taaggttgcg atgagccgtg atcactccac tgcactccag    660
 cctgggtgac cgagctagac tttctagaga ggggcctgga aggaaccaac cccaactttt    720
 tctttcccca agaaaccccc ccgcctttta tagaccagac ccttcggccc tctgtcctca    780
 acactccaca cggtaggagg gtcaccccat cccgcgcagg cgccactccc ggccttcggg    840
 atacg                                                                845



      <210> 1820
      <211> 913
      <212> DNA
      <213> Homo sapiens


      <400> 1820
 accgtggtgg aattcactgt gtatgcaata atgacccatt gtggttttta acttatctca     60
 tgaaaagact taggtttgtt ctcagggtat ttcagatgac tgcctttata actggggcac    120
 atacgattac taactatagt gataggcgtt tatacatttc ccctttgagc catttcttta    180
 tgaacagtgg ttcttctgct caaagtgttc tgtctcattc ttatgtttct caaatcttct    240
 ttaaaaatgt aagcaaatat ttttaaagaa tttttatgtt ttccaaaatt aggattttag    300
 actttaggga ttttgatctt tggggatttc aacattcggg attatggtgt tcagtgtgta    360
 ttttgggggg attatgatca gcatcccata cagtggaata tcatttggca ataaaaagga    420
 attaaatatt gattcatgct acaacatggt gaacctaaaa aacattatgt tcagtgaaag    480
 aagccaaacc tacaaggcct acgtcctgtg tggctcaacg gtacaaatgg ctgaacttat    540
 caccatcaca cccccccacc cctctccagc cccccactac cgacacacaa ccggctcgtt    600
 ccctcactaa tcgcgcacta aagcagaccc tgaccacctc ctcgccgctt cctgaccgcc    660
 gcacccacac tctttgactc ccggggtgca ctaccccccc cacgccaccg ttccctgcgg    720
 cactctccgc ctcaacttcc cccaccccga cccagcccac tccgccctcg ccccacccgc    780
 cgcctccctc tctcgtgacc cctcgcccta ccctctcgcg gtcgactcct cgctcgctcg    840
 ccacgccctc ccctctcctg cacacttccc cctccactcc atatcccctg acgcctccct    900
 ccactgttcc ccg                                                       913



      <210> 1821
      <211> 1885
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1885)
      <223> n = a,t,c or g


      <400> 1821
 tttcgtcccg ccccgcgtgc tggccgcggt aaaagtggta gcagcggagg cgagcggagg     60
 gtttcccgcg gcggagtctc actctgctgc ctaggctgag tgcagtggtg tgatcgaggc    120
 gcactgcagc cttgacctcc tgggctcaag cgatcctcac ctcggcctac cgagtagctg    180
 ggactacagg cacgcgccac tacactcgga tttctgacag tcagacttgt ccacaagaac    240
 tcaactggca aggctgcttt tctgtgctaa aactggggag ctagtgggca ccatgaagat    300
 cttctgcagt cgggccaatc cgaccacggg gtctgtggag tggctggagg aggatgaaca    360
 ctatgattac caccaggaga ttgcaaggtc atcttatgca gatatgctac atgacaaaga    420
 cagaaatgta aaatactacc aaggtatccg ggctgccgtg agcagggtga aggacagagg    480
 acagaaggcc ttggttctcg acattggcac tggcacggga ctcttgtcaa tgatggcggt    540
 cacagcaggt gccgacttct gctatgccat cgaggttttc aagcctatgg ctgatgctgc    600
 tgtgaagatt gtggagaaaa atggctttag tgataagatt aaggttatca acaagcattc    660
 caccgaggtg actgtaggtc cagagggtga catgccatgc cgtgccaaca tcctggtcac    720
 agagttgttt gacacagagc tgatcgggga gggggcgctg ccctcctatg agcacgcaca    780
 caggcatctc gtggaggaaa attgtgaggc cgtgccccac agagccaccg tctatgcaca    840
 gctggtggag tccgggagga tgtggtcgtg gaacaagcta tttcccatcc acgtgcagac    900
 cagcctcgga gagcaggtca tcgtccctcc cgttgacgtg gagagctgcc ccggcgcacc    960
 ctctgtctgt gacattcagc tgaaccaggt gtcaccagcc gactttacag tcctcagcga   1020
 tgtgctgccc atgttcagca tagacttcag caagcaagtc agtagctcag cagcctgcca   1080
 tagcaggcgg tttgaacctc tgacatctgg ccgagctcag gtggttctct cgtggtggga   1140
 cattgaaatg gaccctgagg ggaagatcaa gtgcaccatg gcccccttct gggcacactc   1200
 agacccagag gagatgcagt ggcgggacca ctggatgcag tgtgtgtact tcctgccaca   1260
 agaggagcct gtggtgcagg gctcagcgct ctatctggta gcccaccacg atgactactg   1320
 cgtatggtac agcctgcaga ggaccagccc tgaaaagaat gagagagtcc gccagatgcg   1380
 ccccgtgtgt gactgccagg ctcacctgct ctggaaccgg cctcggtttg gagagatcaa   1440
 tgaccaggac agaactgatc gatacgtcca ggctctgagg accgtgctga agccagacag   1500
 cgtgtgcctg tgtgtcagcg atggcagcct gctctccgtg ctggcccatc acctgggggt   1560
 ggagcaggtg tttacagtcg agagttcagc agcttctcac aaactgttga gaaaaatctt   1620
 caaggctaac cacttggaag ataaaattaa catcatagag aaacggccgg aattattaac   1680
 aaatgaggac ctacagggca gaaaggtctc tctcctcctg ggcgagccgt tcttcactac   1740
 cagcctgctg ccgtggcaca acctctactt ctggtacgtg cggaccgctg tggaccagca   1800
 cctggggcca ggtgccatgg tgatgcccca ngcagcctcg ctgcacgctg tggttgtgga   1860
 gttcaaggac ctgtggcgga tccgg                                         1885



      <210> 1822
      <211> 2273
      <212> DNA
      <213> Homo sapiens


      <400> 1822
 tttttttgtt ttttattttt tctttttaag tttgattttt tttatttcaa aatgctttgc     60
 aattaaatga attactgttc agaagtctcc cacttttcat acaaaaatac tgtgctactg    120
 atacagttga aaaaattcaa tgatgtctct cctgcaggag aaattcacag catccccagg    180
 gtcaacatga aatctggccc tgtccccgcc actgggggct ccccaggcct gcgttcctga    240
 taaactggga caggttttcc aggcactgac caactatcca ccaagggtcc tctgcctcca    300
 agacagaccc tgaatcaata gcagcaactt tcccatattt catgtaggga tatgtggagg    360
 gggacaggaa ctctcccatt tccccagctg ggcctactac ctgcctgccc tgttcactct    420
 ggtgccatga ggcaggttca gtgattgatt ggtcttgcct gctgcagagg acctggccag    480
 ctccagaagg gtcactcatc aggtcctgca aaggtctgta tcattaatca gtgtcatcag    540
 tgtcctcaga agacactagc agagtccagg gtgatgcgtt cagccacaag cacaaagact    600
 gctttttcta aagagcagga tgaggtgaat gtgggaacgg aaagcagttg tcacgaaggc    660
 tgtgtggctc tgctggggga gaggcatcca cagtctgtgc caaggaggta cctcaccctg    720
 tgcagcagga gcgttaaggc caaaaaacaa aaggggccaa cagaaaacag ctcaggtgat    780
 ggggggagga gcagcaagaa aaaacgacaa ccgagaccaa ctgaaggttc ggtcaggaat    840
 gcaggctctt ccgtctatac agtgtttaaa aagatccaaa tgtgactgag atcattccag    900
 cctgcacttt ttatttgtag gcagaaggaa cgggataggt tgaggggcat gacgggggct    960
 ctcgccacct cttgtctgca cctctggaac aggtgggagc cgaatcattc aagtcctacc   1020
 tggtcagact cccaaccacg ctgaggcagg cccttacctg gatggcctca tgggcctccc   1080
 tcttgaaaag accctcactc tgtttggaaa agatccctta gcagccataa tcaggaaaga   1140
 gactctagag cgagcccagg gcttccccaa agcggatttt ctgtcctgtt ttcagctgga   1200
 aattgaagtc cttgggggcc tcgaagatga gcacgatggt ggagcccagg ttgaactcgc   1260
 ccaggtgctc gcccttacgc atggggacgc cctctctatt ggtgtgcgtc acgaagctga   1320
 agtcattgta ggagcccttg ctgtgccttg ggctgtttgt gtgcaggtcc cggtcaaagt   1380
 agatgcgaat ggagcccacg ttggtggccc ccacagctgt cagtgagaag aagccatgtt   1440
 tccagtcccc cgtcaggacc acccgctcgt tatggcagaa gagctctttg atccagcgag   1500
 ccatgccagg gttcactgac atcagggagc ctgggaagtg gcgccggtgg gacacagtcc   1560
 agtcggtggg ggagtggaag cagtggtagt ccccaggggc caggtagatg acacagtgat   1620
 agagctcatt cccttcccgg gtgaccagct ggttcttgaa ggagtcacac gacgcggctg   1680
 gtgggaaggg caggtcctct gtgcacatac gcgggcccag gaacgactcc agggagtagg   1740
 tgaccccctt tacctgctcc acctcacagt tcttcacctg cccaaagttg aggatccttc   1800
 catccgatgg gctaatcacg ctgtgcaggc cacagacagg ccgggcctgc ggcttcagct   1860
 tgcgccggaa gaactcgctg aggttgcggt agtgatgcag gtcctccaca gcggcctctt   1920
 tcatgttcac cccaaacgtc cagatgtaca ggctgtagac gggcctgcgc agccagtgtg   1980
 gcagctccac ctgattgagg cgaccccagg cccgtgacag caagcgcgtt ggcactgact   2040
 tgtacaaagc cacctgcagg ccacagggca aggggctgag ttgcccacac tgccccagct   2100
 ccagagagcc caagtagtgt cattagccca gctctcactt caggggagaa tctgcacccc   2160
 acggaggaca ccagggccca ggtgccccac gctgcttttg tgatgtggct gtttctcact   2220
 gggaaccaga ctgcacttgc cacacggagt gctggattta catacaactc cag          2273



      <210> 1823
      <211> 859
      <212> DNA
      <213> Homo sapiens


      <400> 1823
 cctgtggaag aagagcagga tggagagcat ggtctggtcg atgttgcggt tgcagatgcc     60
 ctcgttgatc aggtagcagg ggtcccgcag caccggctct agcgaatcct gccgcattat    120
 gctgttgagc ttgtcggtat tgaggttctc aaagaccagc ttttcctgca gctgccgaaa    180
 gttgctcact gtagggctgc ccgggttgtt gttctccccg ctgctgcctc gctggagccc    240
 actccgatgg gccaggtcca ggcagcagtt gcagcagtcg aggccgacag gtgagcggca    300
 atcgagcttg gactgggcca tcttctcagg ctcggaggtc gcctggcctg cgaggtcagg    360
 ggcggctggc aggtgcgcgc ccaccgagct ggcctgaggg gactccaggg tgcctggaaa    420
 agacaagctg tgaggaaaag agttggaaat tagcgcctaa agccagccac cttcggctcg    480
 gcccccttct ggctgtactg ctccgggtgc gaatagaaac agctggacaa acagctccga    540
 gcggatcctt cgggctcact tcctcctctt cctccttctc ctccccctcc tcttgaggcc    600
 gggggccgcc cccctgaggt gccacacgcg gccccagcgc agtcccaagt ttcccaagtg    660
 tgagcgggga ttggggcgga cctgtggagg caggaagggc gggcagcagg gcagagggag    720
 agccagggcg cgcccttgct ccctccctcc tttgctccct ccctccccgg tttgcaggct    780
 ctcaggctct cgggctcccc tgggctgtga cggctgagcg gtggcaggag ctgagagcga    840
 gtgagctacg aaatcgtcg                                                 859



      <210> 1824
      <211> 594
      <212> DNA
      <213> Homo sapiens


      <400> 1824
 gcttgagctc gagcgacggc gctggcggag acgccggctg ctcctcccct ccccgccgct     60
 tttcctaaaa ggattgtaca ccttagaagt gcttaaggaa gagtgatgaa gctctgaatc    120
 gtgtcctgca gcagattctg agtgccaccc aagatgaaga gagggacaag cttgcatagt    180
 aggcggggca agccagaggc cccaaaggga agtccccaaa tcaacaggaa gtctggtcag    240
 gagatgacag ctgttatgca gtcaggccga cccaggtctt catccacaac tgatgcacct    300
 accggctctg ctatgatgga aatagcttgt gctgctgctg ctgctgctgc tgcatgtcta    360
 ccaggagagg agggaactgc ggagcggatc gaacggttgg aagtaagcag ccttgcccaa    420
 acatccagtg cagtggcctc cagtaccgat ggcagcatcc acacagactc tgtggatgga    480
 acaccagacc ctcagcgcac aaaggctgcc attgctcacc tgcagcagaa gatcctgaag    540
 ctcacagaac aaatcaagat tgcacaaaca gcccgacgaa atcgtcgacc cggg          594



      <210> 1825
      <211> 2228
      <212> DNA
      <213> Homo sapiens


      <400> 1825
 tttttttttt ttcctgaaat gtaaattgtt tttaatatat ttaagagcac acagaagtct     60
 tgatttataa aaaaataaat atataacatg acaaatttac tgatgatcct ggagctctga    120
 ggtcaaactc tttaaatgat cagtgaaaac ataaaacatc catgatctgt taacacacac    180
 aggagcatat tccagttgta aaaaacaaat tccttgaagg ctcagaacga acaaaaatca    240
 gtctttatgg cagaaagcac atccaaagct aggcaatgaa gttcagcctg ggccacgtga    300
 acctttcacc agccagccta taacctatgg agccaggaca ggaaagcatg atccttcagc    360
 tcatgacgcc acccaggctt ccagacaact gcagaatgaa agagtccctc agaggctccc    420
 cagcccctgc tgccatcata aagcacggga gggattgttt tgtccttagc ggctctgtcc    480
 taaatttgag agcaggagac tgagaaggtt atgctcatta aatattgtca ttgtaacacg    540
 gaatggaaat catgatcctt gcccatgggc actgagctga aagaaagagg aacctcacat    600
 gaggctttcc tagagaccag gatgttgggt gagtgggcgt gcacttctca agtgggcaag    660
 gaagaactgc ttttctccag ctgacatgct ctcaggggtg aagaagttta gcttaaaata    720
 cctgatggcg ctgcataaac tggggatttg ggaactgagt ttttagctct gtgacacaca    780
 acataaaaaa caaaaatcca gtctcattag ctaaattcgg attaaaatct gaaatgtttt    840
 tatggagttg ccaacaggct ggaatgtacc tgatacaatt taatctgctt ttatttcttt    900
 ggctgtcttc caaaccactt tcttcctgta attcttaagt tggctagttc tccttcctca    960
 gaaaaattac ccctaagaat cttcctaata gtgagggtgt acttccgaat agaagagtcc   1020
 ttcggctgaa atggcatctc caaggcctac agttcgaatg gggtctttac acaccaatac   1080
 tggtgtgaag tggaaggata ttccctctct gtgccattct actactggct tgtttgggtt   1140
 taatacaatc ctggagcctg cctccgaatg ggaagtcatg aactcttggg gtgccctcag   1200
 agacactcgg ctggtgtcta tggtttctgt ggcgcaggcc tgtgtcccag ccacacgagc   1260
 tcctgcagcc acggctgcca gctggttggc ccagtgtcca tccacagttg ccaggatgtg   1320
 gtagaccagc gtgtggaaat ggatcctggt gagatccgag gctctgcttt tactcctccc   1380
 atgttctttc aagatccaga agaggatgtc actgaccatg cccacatcag gaacaccgtt   1440
 ccaggaagag agagaagagt gaggtccaga ggctgactgg gtgagaaata acagctcctg   1500
 ttcattcagc ccaagggaag tcaccgcggg aaagacctgc tgaaggaaca atgctgctca   1560
 tgagctccct gttagtcata ctggcccagc tctaggtgaa actggaatac cagtggggat   1620
 gtcagaaatg gaggttacaa cctccaagag tctcttcctc tggagctcct tgctttgtcc   1680
 ctccatcatg tgcaatccag agaggccccc caggtctggc tgaaactcct ccaggctaga   1740
 cacaaacacc tccagcatat tcatggcccc gttggagagg tcgtgagaga agatgaatcg   1800
 gttggcatgg ggagctttta actggcccca ctcctcccct gcttgatact ctaaaatgag   1860
 gtggaactca tccacttcct gcaatgactc tggtggaaca aagacattgt catcaagaag   1920
 ctcatgtagc tttggaccaa ctggaccgca aagaagaacc tttaaatctg agttggctgc   1980
 aaatttctgt ccaattaaag ctgcatttcc tcctacatag tgctgggctc ctgggaactc   2040
 tgacgcaacc tgggcaatgt cgtgaaaagt ttccttatca ctgaagaagc gctcagcagc   2100
 tgctcccttc cccatgaagt gaatgaaggc ttcttccaga tcattccttg aatgcagaat   2160
 gctgtgatct ttcccattcc caggactaag gccaagtgcc tgcaagagct tcacccctga   2220
 ggaattca                                                            2228



      <210> 1826
      <211> 618
      <212> DNA
      <213> Homo sapiens


      <400> 1826
 ggcacgagct cagatagtgc agttaactca gcaggtggac acaaatatat ctgttatttt     60
 acctactgtt catgaggggg atattttcag gtgtttctgc ccagttttcc ttcatagtca    120
 gatgctctgg gagctggtgc tgttggggga gccccttgtg gttatggcgc catcaccatc    180
 ggaatcatca gagactgtat tggcacttgt taactgtatt tctccattaa agtacttcag    240
 tgatttccga ccttatttca ctattcatga tagtgaattc aaagaatata ctacccgtac    300
 ccaagctccg ccctcagtta tattaggagt aaccaaccct ttttttgcta agacactcca    360
 gcactggcca cacattattc gaataggaga ccttaaacct acaggtgaaa ttcctaagca    420
 ggttaaagtg aaaaaactga agaatctaaa gactctggat tccaaacctg gagtttatac    480
 ttcatataag ccatattcta actagagatg aagagatcat acaacagcta cagaggggcg    540
 taccacacaa aacgcgcttt tgaggctcaa cagtggtatt cttcgacgct attttttgga    600
 actgacacaa agtttcag                                                  618



      <210> 1827
      <211> 1608
      <212> DNA
      <213> Homo sapiens


      <400> 1827
 gggttccgtg gccctgcacg tggagaagct gcccaatgag cccaaccgct tgcttatcct     60
 ccacggcttc ctggacgaaa acgtgcactt tttccacaca aacttcctcg tctcccaact    120
 gatccgagca gggaaacctt accagctcca ggtggccctg cctcctgtct ccccgcagat    180
 ctaccccaac gagagacaca gtattcgctg ccccgagtcg ggcgagcact atgaagtcac    240
 gttgctgcac tttctacagg aatacctctg agcctgccca ccgggagccg ccacatcaca    300
 gcacaagtgg ctgcagcctc cgcggggaac caggcgggag ggactgagtg gcccgcgggc    360
 cccagtgagg cactttgtcc cgcccagcgc tggccagccc cgaggagccg ctgccttcac    420
 cgccccgacg ccttttatcc ttttttaaac gctcttgggt tttatgtccg ctgcttcttg    480
 gttgccgaga cagagagatg gtggtctcgg gccagcccct cctctccccg ccttctggga    540
 ggaggaggtc acacgctgat gggcactgga gaggccagaa gagactcaga ggagcgggct    600
 gccttccgcc tggggctccc tgtgacctct cagtcccctg gcccggccag ccaccgtccc    660
 cagcacccaa gcatgcaatt gcctgtcccc cccggccagc ctcccccact tgatgtttgt    720
 gttttgtttg gggggatatt tttcataatt atttaaaaga caggccgggc gcggtggctc    780
 acgtctgtaa tcccagcact ttgggaggct gaggcgggcg gatcacctga ggttgggagt    840
 tcaagaccag cctggccaac atggggaaac cccgtctcta ctaaaaatac aaaaaattag    900
 ccgggtgtgg tggcgcgtgc ctataatccc agctactcgg gaggctgagg caggagaatc    960
 gcttgaaccc gggaggtgga ggttgcggtg agccaagatc gcaccattgc actccagcct   1020
 gggcaacaag agcgaaactc tgtctcaaaa taaataaaaa ataaaagaca gaaagcaagg   1080
 ggtgcctaaa tctagacttg gggtccacac cgggcagcgg ggttgcaacc cagcacctgg   1140
 taggctccat ttcttcccaa gcccgagcag agggtcatgc gggccccaca ggagaagcgg   1200
 ccagggcccg cggggggcac cacctgtgga cagccctcct gtccccaagc tttcaggcag   1260
 gcactgaaac gcaccgaact tccacgctct gctggtcagt ggcggctgtc ccctccccag   1320
 cccagccgcc cagccacatg tgtctgcctg acccgtacac accaggggtt ccggggttgg   1380
 gagctgaacc atccccacct cagggttata tttccctctc cccttccctc cccgccaaga   1440
 gctctgccag gggcgggcaa aaaaaaaagt aaaaagaaaa gaaaaaaaaa aaaaagaacc   1500
 aacccacctc tacatattat ggaaagaaaa tatttttgtc gattcttatt cttttataat   1560
 tatgcgtgga agaagtagac acattaaacg attccagttg gaaacatg                1608



      <210> 1828
      <211> 1608
      <212> DNA
      <213> Homo sapiens


      <400> 1828
 gggttccgtg gccctgcacg tggagaagct gcccaatgag cccaaccgct tgcttatcct     60
 ccacggcttc ctggacgaaa acgtgcactt tttccacaca aacttcctcg tctcccaact    120
 gatccgagca gggaaacctt accagctcca ggtggccctg cctcctgtct ccccgcagat    180
 ctaccccaac gagagacaca gtattcgctg ccccgagtcg ggcgagcact atgaagtcac    240
 gttgctgcac tttctacagg aatacctctg agcctgccca ccgggagccg ccacatcaca    300
 gcacaagtgg ctgcagcctc cgcggggaac caggcgggag ggactgagtg gcccgcgggc    360
 cccagtgagg cactttgtcc cgcccagcgc tggccagccc cgaggagccg ctgccttcac    420
 cgccccgacg ccttttatcc ttttttaaac gctcttgggt tttatgtccg ctgcttcttg    480
 gttgccgaga cagagagatg gtggtctcgg gccagcccct cctctccccg ccttctggga    540
 ggaggaggtc acacgctgat gggcactgga gaggccagaa gagactcaga ggagcgggct    600
 gccttccgcc tggggctccc tgtgacctct cagtcccctg gcccggccag ccaccgtccc    660
 cagcacccaa gcatgcaatt gcctgtcccc cccggccagc ctcccccact tgatgtttgt    720
 gttttgtttg gggggatatt tttcataatt atttaaaaga caggccgggc gcggtggctc    780
 acgtctgtaa tcccagcact ttgggaggct gaggcgggcg gatcacctga ggttgggagt    840
 tcaagaccag cctggccaac atggggaaac cccgtctcta ctaaaaatac aaaaaattag    900
 ccgggtgtgg tggcgcgtgc ctataatccc agctactcgg gaggctgagg caggagaatc    960
 gcttgaaccc gggaggtgga ggttgcggtg agccaagatc gcaccattgc actccagcct   1020
 gggcaacaag agcgaaactc tgtctcaaaa taaataaaaa ataaaagaca gaaagcaagg   1080
 ggtgcctaaa tctagacttg gggtccacac cgggcagcgg ggttgcaacc cagcacctgg   1140
 taggctccat ttcttcccaa gcccgagcag agggtcatgc gggccccaca ggagaagcgg   1200
 ccagggcccg cggggggcac cacctgtgga cagccctcct gtccccaagc tttcaggcag   1260
 gcactgaaac gcaccgaact tccacgctct gctggtcagt ggcggctgtc ccctccccag   1320
 cccagccgcc cagccacatg tgtctgcctg acccgtacac accaggggtt ccggggttgg   1380
 gagctgaacc atccccacct cagggttata tttccctctc cccttccctc cccgccaaga   1440
 gctctgccag gggcgggcaa aaaaaaaagt aaaaagaaaa gaaaaaaaaa aaaaagaacc   1500
 aacccacctc tacatattat ggaaagaaaa tatttttgtc gattcttatt cttttataat   1560
 tatgcgtgga agaagtagac acattaaacg attccagttg gaaacatg                1608



      <210> 1829
      <211> 1608
      <212> DNA
      <213> Homo sapiens


      <400> 1829
 gggttccgtg gccctgcacg tggagaagct gcccaatgag cccaaccgct tgcttatcct     60
 ccacggcttc ctggacgaaa acgtgcactt tttccacaca aacttcctcg tctcccaact    120
 gatccgagca gggaaacctt accagctcca ggtggccctg cctcctgtct ccccgcagat    180
 ctaccccaac gagagacaca gtattcgctg ccccgagtcg ggcgagcact atgaagtcac    240
 gttgctgcac tttctacagg aatacctctg agcctgccca ccgggagccg ccacatcaca    300
 gcacaagtgg ctgcagcctc cgcggggaac caggcgggag ggactgagtg gcccgcgggc    360
 cccagtgagg cactttgtcc cgcccagcgc tggccagccc cgaggagccg ctgccttcac    420
 cgccccgacg ccttttatcc ttttttaaac gctcttgggt tttatgtccg ctgcttcttg    480
 gttgccgaga cagagagatg gtggtctcgg gccagcccct cctctccccg ccttctggga    540
 ggaggaggtc acacgctgat gggcactgga gaggccagaa gagactcaga ggagcgggct    600
 gccttccgcc tggggctccc tgtgacctct cagtcccctg gcccggccag ccaccgtccc    660
 cagcacccaa gcatgcaatt gcctgtcccc cccggccagc ctcccccact tgatgtttgt    720
 gttttgtttg gggggatatt tttcataatt atttaaaaga caggccgggc gcggtggctc    780
 acgtctgtaa tcccagcact ttgggaggct gaggcgggcg gatcacctga ggttgggagt    840
 tcaagaccag cctggccaac atggggaaac cccgtctcta ctaaaaatac aaaaaattag    900
 ccgggtgtgg tggcgcgtgc ctataatccc agctactcgg gaggctgagg caggagaatc    960
 gcttgaaccc gggaggtgga ggttgcggtg agccaagatc gcaccattgc actccagcct   1020
 gggcaacaag agcgaaactc tgtctcaaaa taaataaaaa ataaaagaca gaaagcaagg   1080
 ggtgcctaaa tctagacttg gggtccacac cgggcagcgg ggttgcaacc cagcacctgg   1140
 taggctccat ttcttcccaa gcccgagcag agggtcatgc gggccccaca ggagaagcgg   1200
 ccagggcccg cggggggcac cacctgtgga cagccctcct gtccccaagc tttcaggcag   1260
 gcactgaaac gcaccgaact tccacgctct gctggtcagt ggcggctgtc ccctccccag   1320
 cccagccgcc cagccacatg tgtctgcctg acccgtacac accaggggtt ccggggttgg   1380
 gagctgaacc atccccacct cagggttata tttccctctc cccttccctc cccgccaaga   1440
 gctctgccag gggcgggcaa aaaaaaaagt aaaaagaaaa gaaaaaaaaa aaaaagaacc   1500
 aacccacctc tacatattat ggaaagaaaa tatttttgtc gattcttatt cttttataat   1560
 tatgcgtgga agaagtagac acattaaacg attccagttg gaaacatg                1608



      <210> 1830
      <211> 433
      <212> DNA
      <213> Homo sapiens


      <400> 1830
 atcttgacga ggctgcggtg tctgctgcta ttctccgagc ttcgcaatgg taagcttcag     60
 gggtgtgaag tcgccggcgt tcttgggttt gaggactcag tggggagagc cttcggcggg    120
 agcgctcctt ggcctgccgg cctcggttgc agggcgggcg cggttattgc ttggcccatg    180
 tgctctggtg gtggagtttg cgggggctgg gggcgcagta ttaggggact ttggcgctat    240
 ttgaggacct ggttgcattc ccgctgccct cctacagccg cctaaggacg acaagaagaa    300
 gaaggacgct ggaaagtcgg ccaagaaaga caaagaccca gtgaacaaat ccgggggcaa    360
 ggccaaaaag aaggtagaaa taagacctct ctgaaagaga ctaggggtaa ctctctcgta    420
 accctctagt aat                                                       433



      <210> 1831
      <211> 1783
      <212> DNA
      <213> Homo sapiens


      <400> 1831
 ctggcttgtc tggagccagc ctgtagggtt ggggagcctt tctctccata gttccagggt     60
 ttggtgaagc atcttacacc agtaagtatt gattgaacgt ctgtcagtga cctctgcaaa    120
 ctctgctttt gttgtaggaa gcagtacagg ttttgattaa gcactcagct gatgtcaatg    180
 caagggacaa gaactggcag acccctcttc atgtggcagc agccaacaag gctgtcaaat    240
 gtgcagaagt gatcattccc ctgctgagca gtgtcaatgt ctccgaccga ggggggcgca    300
 cagccttgca ccatgcggct ctgaacggcc acgtggagat ggtcaattta ctcttggcca    360
 aaggggcaaa tatcaatgca tttgacaaga aggaccggcg tgctctgcac tgggcagcat    420
 acatgggcca cttggatgtt gtagcattgc tcattaacca tggcgcagaa gtgacctgta    480
 aggataagaa gggttatacc cctctgcatg ctgcagcctc caatggacag attaatgttg    540
 tcaagcatct cctgaacctg ggggtggaga ttgatgaaat caatgtctat ggaaatacag    600
 cgcttcacat cgcctgctac aatggacagg atgctgtggt taacgagttg attgactacg    660
 gtgctaacgt gaaccagcca aacaataatg ggttcacccc tttgcatttt gctgctgcct    720
 ccactcatgg tgctttgtgt cttgaattgt tagtaaacaa cggggcagat gttaacattc    780
 agagtaaaga tggcaaaagt ccactgcaca tgacagctgt ccatggaagg ttcacacggt    840
 cacagaccct cattcagaat ggaggtgaaa ttgactgtgt ggataaggac ggcaacactc    900
 ctctccatgt ggctgcaaga tacggtcatg agcttttgat taacacctta ataaccagcg    960
 gagctgacac agccaagtgt ggaatccata gcatgttccc tttacattta gctgccctaa   1020
 atgctcactc tgactgctgc agaaagttgt tatcatcggg acaaaagtat agcatagtat   1080
 ccttgtttag taatgagcac gtgctgtctg caggctttga aatagacacc ccagataaat   1140
 ttggaagaac gtgccttcat gctgctgctg caggaggtaa tgtggaatgt ataaaactct   1200
 tgcagagcag cggagcagat ttccataaaa aggacaagtg tgggaggacc cctttgcact   1260
 atgcagctgc gaattgtcat ttccactgta ttgagacatt agtgaccaca ggggccaacg   1320
 ttaatgaaac agatgactgg ggacgcacag ctttgcatta cgccgctgca tcagacatgg   1380
 atagaaataa gactatctta ggaaatgccc atgataattc agaagaactt gaaagagcca   1440
 gggagctgaa ggaaaaggaa gccacactat gtctagagtt tctgcttcaa aatgatgcaa   1500
 atccatctat ccgggacaag gaaggttaca atagcataca ttatgctgcc gcctatgggc   1560
 acaggcagtg tctggaattg cttttggaaa gaacaaacag tggatttgaa gaatcagatt   1620
 ctggtgctac taagagtcca ctccacttag ctgtaagtga gatgccatga gcagcttcac   1680
 ctgttacaaa aacaacctaa gcattcctaa aactagattg ctcttaaaat gtaaatgtag   1740
 taacacagtg atgagtggta gtgaaagtag tccgtggtaa aag                     1783



      <210> 1832
      <211> 1266
      <212> DNA
      <213> Homo sapiens


      <400> 1832
 tttttttttt ttggggggct aggtataatt ttattttata taaaaagtgt ttctgtgatt     60
 cttcagagcc caggagtcag tgctggtggt tggagggacc tgcccccact ggttcattta    120
 accctctgtc tcggtgccct cagaacctca gccagaaagg caaggaggaa atcagagcag    180
 gagcctcata ctcttggtga tctattcatt ctgtgacctc aggggtcaca tataaggtca    240
 gtgtttctcg tccccgccgg atctgcactg ccaactggga ttgggttcga acagcttcat    300
 aaacatcttc agcattttgt accatctgct ccccaatggc caaaatcaca tcaccaggcc    360
 gcagaccagc ccggtgtgca ggggagccca ggatgacttt atggatgagt acaccatgct    420
 gaacatcggg aaagcttggt tctcgaagct gtagttcagc aaggatgctg ggactcaggg    480
 tcagcatcat caccccaatg tagcgccgct gggacccact gattccggag gaggaattct    540
 tcttttcccc acgatgcaga aactctcgaa gacgatcaga agggatggca aaggagattc    600
 cagctgtgac cttcatggtg ttcactccaa tcacctcccc atccaggtta accaggggac    660
 ctccagagtt tccaaaatca atagctgcat cagtttgaat gtattccaca ttggtttggg    720
 ggagtcccag gtctctggct ggacgctgag cagagctaac aatgccggat gtgatcgtgt    780
 tctgcagtgc aaagggactt cccatggcaa caacaaactc cccttgccgg acatcagctg    840
 agcgtcccag aggcagcgtg gggagaggct ccttagtctg aatcctcagc gttgcgatgt    900
 ctgccacggg atccacagct gtgaccacgg cctcatacgt gtcgccgctt agcagtctca    960
 cacggactct gcgccgatca gccaccacat gggcgttggt gacaatgagc ccatcggcag   1020
 ccaccacgaa tcctgagccg ttcgagatag ggacctcgcg gcccaagaaa gggtgccggt   1080
 ccaggatctc gatatagacc acggcaggtg ctgtcttctc caccacatct gcgatgaagt   1140
 tgtactgact gaagtccttc agaagtgcac gccgggacca ggattccggg aggccgactc   1200
 ctccctgccc cacgaatgcc gggaattgtg gtctccgccg gacgcgagtt gtgagacggc   1260
 ccaagg                                                              1266



      <210> 1833
      <211> 404
      <212> DNA
      <213> Homo sapiens


      <400> 1833
 tttcgtctgt gagctgcggc agctgagcag aggcggcggc gcgggacctg cagtcgccag     60
 ggattccctc caggtgacga tgctctggtt ctccggcgtc ggggctctgg ctgagcgtta    120
 ctgccgccgc tcgcctggga ttacgtgctg cgtcttgctg ctactcaatt gctcgggggt    180
 ccccatgtct ctggcttcct ccttcttgac aggttctgtt gcaaaatgtg aaaatgaagg    240
 tgaagtcctc cagattccat ttatcacaga caacccttgc ataatgtgtg tctgcttgaa    300
 caaggaagtg acatgtaaga gagagaagtg ccccgtgctg tcccgagact gtgccctggc    360
 catcaagcag aggggagcct gttgtgaaca gtgcaaaggt tgca                     404



      <210> 1834
      <211> 1020
      <212> DNA
      <213> Homo sapiens


      <400> 1834
 cgtgcactaa tacgactcct ccccccaaag tccgatcaag gtggggaaac ggccaagggt     60
 tttttccaag tcacccccgt gttaaaaccc ccggccaggg cccaaggctg gcaatgcccg    120
 ccggtcggcc ttatagggtt aaacgggggc ggcatcctgc gaccgggcca ttggactggg    180
 ttcgaaagcc aaaggtcatt acgccccagg gtaaatctcg caagttcatt aagggcgcta    240
 tagaccagtc gaagacagtc aggcggcagt agtgcattga acattcagca ccccgtcacc    300
 gcctgattgc tcaggacctc tatatcgacg aaatggagtt catcatatga ctcacgctcg    360
 cgacgacatc agagtaggca cactgtgcct ccccttcatt ggtaactgct ggctaatacc    420
 atggggtgaa gtggtcagca atccattaaa ggcgcagcgg ctcgctgagg aatatcggga    480
 aaggcaggag gcagcatgag atccggatct gtttgcagtg gagctgcggc gatgcccata    540
 gaagaaccgg cgctgcgcag ctggcagcgc ccgttcctta aatgggctgg cggcaaatat    600
 tcgctgctgc cggaactgga tcgtttgatc cccgcaggta aacgccttat tgagcctttt    660
 gtgggtggcg gctcggtgtt ccttaactca gacaagcacg aacgcttcct tctggctgac    720
 gtcagcgctg acctgattaa cctgtatcag atgctggcgg tggtccccga ttcggtgatc    780
 tatgaggcaa tgaaggcatt caggcatctt aatgatgccg aaaactatac gttaattcgt    840
 gaagcattca acgcgcagcg gctggatgcg gtcgagcgtg cagcagcatt cctttacctc    900
 aatcggcact gcttcaacgg cctgattcgt tacaacctgg acggtttttt tcagcaaggc    960
 cattaagaaa gataacgcca ggtttttccc agacaaagcg ttgtacagcg gacggacagt   1020



      <210> 1835
      <211> 458
      <212> DNA
      <213> Homo sapiens


      <400> 1835
 ggacacttca gagtcccggc cttgggctac ctggacgtgc gcatcgtgga cacagactac     60
 agctccttcg ccgtccttta catctacaag gagctggagg gggcgctcag caccatggtg    120
 cagctctaca gccggaccca ggatgtgagt ccccaggctc tgaaggcctt ccaggacttc    180
 tacccgaccc tggggctccc cgaggacatg atggtcatgc tgccccagtc aaatgcatgc    240
 aaccctgaga gcaaggaggc gccctgacac ctcgggagcc ccacccccgc ccttcccagg    300
 tggagccaaa gcagcaggcg cctttgcccc tggagtcaag acccacagcc ctcggggacc    360
 acctggagtt tttccatcct ccaccccccg cctgtgggat gccttgtggg aggttttttt    420
 ttattcaata aacagatgct gcagccaaaa aaaaaaaa                            458



      <210> 1836
      <211> 1404
      <212> DNA
      <213> Homo sapiens


      <400> 1836
 gctgagaaag gagggccgct gcaggcgggg ttcgaaccgt ggggtctggg ctgctcccgc     60
 ggagggcctg ggcggacgcg ggatgctggg ggtccgctgc ctgctgcggt ccgtgcgctt    120
 ctgttcctcc gcccccttcc ccaagcacaa accttcagcc aaactgagcg tgcgggacgc    180
 tctcggggct cagaacgcga gtggggagcg cattaagatc cagggatgga ttcgttctgt    240
 ccgatcccag aaggaagtct tgttcctgca tgtaaatgat gggtcatctt tggaaagcct    300
 tcaggttgtt gcagattcag gccttgacag tagagaatta acttttggga gttctgtgga    360
 agtacaaggg cagctgataa aaagtccatc caaaaggcaa aatgtggaac tgaaggcaga    420
 aaaaattaaa gttattggaa attgtgatgc caaggatttc cccatcaaat ataaagagag    480
 gcatcctctg gagtacctgc gacaatatcc tcactttagg tgtaggacta acgttctggg    540
 ttctatattg aggattcgca gtgaagcgac agctgctatt cattctttct ttaaggacag    600
 tggctttgta catattcata ctccaataat cacatccaat gactctgagg gagctggaga    660
 actttttcaa cttgaacctt caggcaaact taaggtacct gaggagaatt tcttcaatgt    720
 tcctgctttc ttaactgtct caggacaact tcatctagaa gtgatgtcag gagcttttac    780
 tcaagtgttt acctttggtc cgaccttccg agctgaaaat tctcagagcc ggaggcacct    840
 ggcagagttt tatatgatag aagcagagat ttcttttgtt gacagccttc aagatcttat    900
 gcaggttata gaggaactgt tcaaggctac aacaatgatg gttctctcaa aatgtcctga    960
 agatgttgaa ctctgtcaca aattcatagc acctggccaa aaggacagat tataacatat   1020
 gctaaaaaac aactttttaa tcatttctta tactgaagca gtggagatct taaagcaagc   1080
 atcccagaac ttcaccttta ccccagagtg gggtgctgac ctacggactg aacatgaaaa   1140
 gtacctggtg aagcactgtg gcaacatacc tgtcttcgtt attaattatc cattaacact   1200
 caagcctttc tacatgaggg ataatgaaga tggccctcag gaactagagg gaagtgtagc   1260
 ttaacacagc ctggggttga tgattctcct tagtattgta gtcattggtc agccttaaat   1320
 gttcatactt gtgcaaagtc attaatggat aaatacagca tggtggctag tggcatagat   1380
 ttagagtcag agagacttga gttc                                          1404



      <210> 1837
      <211> 741
      <212> DNA
      <213> Homo sapiens


      <400> 1837
 agatttttac taaggttgtt tagtgtagat tagctgtgaa tatcttgact cctttaaggt     60
 aataaggctt ttgtttgttt ttatctttca cagctagaaa attatggcat gccgtttagc    120
 agaactgaag atgggaagat ttatcagcgt gcatttggtg gacagagcct caagtttgga    180
 aagggcaggc aggcccatcg gtgctgctgt gtggctgatc ggaccggcca ctcaatattg    240
 cacacctcat atgggaggtc tctgagatat gataccagct attttgtgga gtattttgcc    300
 ttggatctcc tgatggagaa cagggagtgc cgtggtgtca tcgcacagtg caatgaggac    360
 gggtccatcc atcacataag agcaaagaac actgttgttg ccacagggta ggaatctaat    420
 ttctacttta tttcctttgt aaaaatgaat aaatttcttt tagagtgtct ttattttaag    480
 gaaaatagag gcattgtaga atagcagttc agacacaggc cttgatataa ccatgtgagg    540
 gtgatggcct ttcccagccg tggttcctca cctgtaaaga gtgaggacag cagcacctgc    600
 ctcggggtga gaaagcatgg ccctcagtag tcggtagtgg ctgccgtcag cttcacagct    660
 tacctctccc gattttagat gaggcacctg cggcccaaag agtcacatgg ggttttctgg    720
 caaaatctct ctttgtttag t                                              741



      <210> 1838
      <211> 2012
      <212> DNA
      <213> Homo sapiens


      <400> 1838
 tggactcttt ggacaaccac aggtgccgag gggacctgac caagacctac agcctggagg     60
 cctatgacaa ctggttcaac tgcctgagca tgctggtggc cactgaggtg tgccgggtgg    120
 tgaagaagaa acaccggacc cgcatgttgg agttcttcat tgatgtggcc cgggagtgct    180
 tcaacatcgg gaacttcaac tccatgatgg ccatcatctc tggcatgaac ctcagtcctg    240
 tggcaaggct gaagaaaact tggtccaagg tcaagacagc caagtttgat gtcttggagc    300
 atcacatgga cccgtccagc aacttctgca actaccgtac agccctgcag ggggccacgc    360
 agaggtccca gatggccaac agcagccgtg aaaagatcgt catccctgtg ttcaacctct    420
 tcgttaagga catctacttc ctgccacaaa atccatacca accacctgcc caacgggcac    480
 attaacttta agaaattctg ggagatctcc agacagatcc atgagttcat gacatggaca    540
 caggtagagt gtcctttcga gaaggacaag aagattccag agttacctgc tcacggcgcc    600
 ccatcctaca gcgaggaagc tctcttcgtc gccctccttt gaaagtgagg gtcccgagaa    660
 ccacatggaa aaagacagct ggaagaccct caggaccacc cttctgaaca gagcctgagg    720
 cggatgcagc ccgcgacgcc agaggaagca cgtgcactaa ctgggtttaa attttgactg    780
 atgtgggttg agaatgagga gcccctcact ggttggggtc cattttgtat ataactttta    840
 tgagaaaaaa atggtaatta tttcacgcat caacctttgg cacttacaaa gttttttttg    900
 ttgtatttta aataacaggg caaggccctg ctttggggag ggggagggga gagtatcatg    960
 ggagatggta tccatgataa catcttattc taatgagatg tagagtatta ttttttactt   1020
 tttgattatt aacatcttat gaaaaaaata ttttaaaaaa cccagccaaa accaacgtga   1080
 gccctgcctg ctcggacgcc tttccagcca gtgtctctga cgtcggggtt agtgccttaa   1140
 agggtactgg gggtctggtc ttcctgctct gtggtttggg ctgcggtgag tcccactcca   1200
 cctgggcgcc tgccctcagg agcctgggct gcgaggctcc ataggagggc tggtggctgg   1260
 gaggtcgcgt ccgcacactt ctggaagtga gcctttgagt acgggctgtc caaagtttac   1320
 attttcattt tcctttcagg gatttgtggg gtcagggagg ggcagggggc acctggcagc   1380
 atattttctg tgacaatgtg tccagcaaat cattcttcaa ctacatttta gaaaggagga   1440
 aatctaaaat aaggttatgg agtggaagca tggagttgac agtcttctgg gctgtgactg   1500
 aaagacacac tgagctgtga tgaagaacaa tacatggccg actccacgga ggagacattt   1560
 agagctaggc ttgaaaccta tcatctacag aggggagggc agccatcagc cctcttccca   1620
 cctgggtagg cagcgcccta attggaattg gaaacagaaa attcgccagg ccatactgct   1680
 ggagcccatt cagataaaac tgcccaatac tgagaggtgt tttctacacc cagctagagg   1740
 agcacactcc atttttccat ggctgagatt ccggggggaa agccctgggc cttactgacc   1800
 atggcgcagg acagctgtcc ttcagaaagc acacggtcaa tccacgtgga ccgtctccct   1860
 cgcaggaact ccgcatcctt gtccctctct gcattcccag tttccgcagg agccttgatc   1920
 aatggggaag cctgggtgag gatgggccag gtcccaattc ccaaagctcc tggaagagcc   1980
 tgaagacatt gtgaaaggct gggcctgggg ag                                 2012



      <210> 1839
      <211> 801
      <212> DNA
      <213> Homo sapiens


      <400> 1839
 tttcgacaca gagctgctgc tgctggactt tggtgtttgt ggatggcacg acaggcggag     60
 aagaatttcc tctgtgtgcg catttaaaca ggtcggtagg ctccacgaca aaagtccacc    120
 cttctgtaaa tcacctgctg tggctatgat gctctgagtt caatacgtaa gaacctttgc    180
 tgtctatgga tctgctctaa accttatagc ctgcttatgg gggaaggtga cgccttctgg    240
 gccccatctg tccttcctca cagcaccctc agcaccttaa gccaccaccc tcagccacaa    300
 tttggcagag ggatggagtc caaggtctca caaggtggcc tgaatgtgac cctcaccatc    360
 cgcctgctga tgcatggaaa ggaagttgga agcatcatcg ggaagaaagg agaaactgtg    420
 aagaagatgc gtgaggagag tggtgcaagg atcaacatct cagagggaaa ctgcccagag    480
 aggattgtga ccatcacagg ccccacagac gccatcttca aggcctttgc catgatcgca    540
 tacaagtttg aggaggatat catcaactcc atgagcaaca gccctgccac cagcaagccc    600
 ccagtgacgc tgaggctggt ggtgcctgcc agccagtgtg ggtccctgat cggcaaagga    660
 ggctccaaga tcaaggagat cagggaggta acaggacctt cccagcctgg gccgctgcgg    720
 agcctctagg cgggctgcgg gtggtggcca caggccaggc agccttcctg agccttgtcc    780
 ctgctgtctg caagcccaat g                                              801



      <210> 1840
      <211> 404
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(404)
      <223> n = a,t,c or g


      <400> 1840
 aatacacccc tctgaaagtt aattaagaat gaannnnnnn nnnnnnnnnn nnnnnnnnnn     60
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    120
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    180
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnntagataa    240
 atgtttgtag ctaaaacaca cgaaatatca cgaacagtct ttttaaagat aaaacatgta    300
 atcaccataa caactggaag caataatgtc tttgtgtatc tcagtggagt cgctttttcc    360
 atgaagtcaa attcgggagc acaggtgtat attaaagtat caan                     404



      <210> 1841
      <211> 1671
      <212> DNA
      <213> Homo sapiens


      <400> 1841
 ttttttttta tttttttttt tcatgttaga aattccttta ttccttatca aaacaaacta     60
 acagtaaacg tatattatat gctttaattt tatacatata agttatcttg tttggataca    120
 tctttcatca ggactctgcc acatccatac tttgtccttg tggtgagaga ggataaaatg    180
 tgatataatt tgttattcaa agaacatggc aaccgtaaca gacaaaagga agcatggcat    240
 ctaggggagg agagtggaga gttttccata cacaaacaca tttaaacttc cctgtacaaa    300
 aatacctgct gttgctttag aaatcgtttt cctttatgaa tagtcaggtc ttgcagtaca    360
 aatccaggtg cagtgccagc aagtatttca aataaatttc aacgacttga tattcaagtc    420
 caaactaaat atttaatgtt ttctttattg caaatatgat gtctttgacc tgaggtatag    480
 agttgtcctc tagaatcttt gcataaggca tagggacatc agcaccagtg acacgaacag    540
 caggagcatc caggaaaatt gaacgcagga ccttcccatg atcctggcac agatttcaag    600
 ctcctactcc caaactgtgg ccagcctcct tcccacagtt acaagatgaa ttttgtcttc    660
 atgacactgg gcttctatgg gtttccatgt ccattgggtc taatgggtac gcatatttat    720
 cacctcagca ttcgactcct tctttagata ggcactggct ggcaggcttc taaggcagtg    780
 ggcccacagg tcttgaatgg gaaaccacag ttatatgtgt tccgtgcatt tctattttgg    840
 cttttccaat aggaatcatg aaaatctttt gactgagctt ccggaggaaa ttcaaaaggg    900
 aaccccatac atcaattcat tctctagcgc caccactgga ttgttatccc gaatggctga    960
 tttaataagt cctttagcat cctacgaagt cctagggact gaccaccttt aagcctgggc   1020
 agtgcccata ccaggcagca aagcactgtg agtgctgggc agctacacct gctgaagcac   1080
 caattgggcc cccatgatac tataagcaca ggctgaaggc caaccagaac atgtagtagg   1140
 tcttggcagc tgagtttata acctggtcaa atggcttgcc atggagaaat tgaaggtcca   1200
 taaattcaac aaaatgggcc gcaaacccca gccaatagct gcacctacaa gcaattccca   1260
 agcaaagccc atctctgata tgggagtgtc aaataatcct cttgtctcca tatttcttcc   1320
 acagccctcg actaaccttg tatgccccat catagctggg caacttcttc tccaagcaga   1380
 aataccttct catctctttc cagctcctca tccataccct gatttatagc atcacgaact   1440
 gtcaacctgc acggcagccg gcgcggtcca gtgaaagcgc ctcttcagca gcccagagac   1500
 ctcccgaagg ggtctccgca ccaagccaga caccgccgcc atcttggtcg tgtcctctat   1560
 ccgctgccaa acgaccccag aggggccggc agacgtgagc acgcccgcct ccaccggcgc   1620
 gggcaatggc aaggcgcgcc ggctgcgtga cccgcccacc cgcccaccgg t            1671



      <210> 1842
      <211> 1872
      <212> DNA
      <213> Homo sapiens


      <400> 1842
 ccaggaccca gcagtgccct ctgtccactg ctctgggcca ttccccaatc ccccctccca     60
 cttgagcccc taactcagaa tctgggaccc aggggcccct ccctacccca gctaacctct    120
 tctggaccag gagagccaac ccagatccca ctacctccat gagtgctaca gacaggatgg    180
 ggcccaaagc tgtgccgggt ctgcggctgg cactgctgtt gctgctgggg ctagggacac    240
 ccaagtcagg ggtacagggg caggaagggc tggacttccc tgagtacgat ggtgtggacc    300
 gtgtgatcaa tgtcaatgca aagaactaca agaatgtgtt caagaagtat gaggtgctgg    360
 cactcctcta ccatgaaccc cccgaggatg acaaggcctc acaaagacaa tttgagatgg    420
 aggagctgat cctggagtta gcagcccaag tcctagaaga caagggtgtt ggcttcgggc    480
 tggtagactc tgagaaggat gcagctgtgg ccaagaaact aggcctaact gaagtggaca    540
 gcatgtatgt attcaaggga gatgaagtca ttgagtacga tggcgagttt tctgctgaca    600
 ccatcgtgga gtttctgctt gatgtcctag aggaccctgt ggaattgatt gaaggtgaac    660
 gagagctgca ggcgtttgag aatattgagg atgagatcaa actcattggc tacttcaaga    720
 gcaaagactc agagcattac aaagccttcg aggatgcagc tgaggagttt catccctaca    780
 tccccttctt cgccaccttc gacagcaagg gggcaaagaa gctgaccctg aagctgaatg    840
 agattgattt ctacgaggcc ttcatggaag agcctgtgac catcccagac aagcccaata    900
 gcgaagagga gattgtcaac ttcgtggagg agcacaggag atcaaccctg aggaaactga    960
 agccggagag tatgtatgag acctgggagg atgatatgga tggaatccac attgtggcct   1020
 tcgcagagga agctgatcct gatggtttcg agttcttaga gactctcaag gctgtggccc   1080
 aagataacac tgaaaaccca gatcttagca tcatctggat tgaccctgat gacttccccc   1140
 tgctggtccc atactgggag aagacgtttg acatcgactt gtcagcccca caaataggag   1200
 tcgtcaatgt tactgatgcg gataggctat ggatggaaat ggacgatgag gaggacctgc   1260
 cttctgctga ggagctggag gactggctgg aggatgtcct ggagggcgag atcaacacag   1320
 aggacgatga cgatgatgat gatgactagt tgctatggca accatctttc agccccactg   1380
 gtcttttcat gctctctcct gccttccctt gtccttccct gagttcctcc agggagacta   1440
 ggttattctc tgccatagag ctaactgggg tctatatgct gggtgctgag acactgatcc   1500
 ccctcatttg atgagcaaat gagctacttt tccctagaca ccaggcccag ctcttctctt   1560
 atctgacttc tgtttcttat ccccataact tacgttgtat ctattatgtg tctcttccat   1620
 cactctccat actctttctt gtgattctcc tctagccata tatatgggcc cctatctctg   1680
 ttctgttccc tccatctatg cacagctttc ccccactctc tctaatcctg tatctttctg   1740
 actgtcctgt ccttggccag aaggaaggga gaatactgtg tttgggactg tatctcagca   1800
 atcacttgtt aatgtatttg ggtcaaatga gaggcctcaa taaagacatc tggggcagca   1860
 tgaaaaaaaa aa                                                       1872



      <210> 1843
      <211> 3773
      <212> DNA
      <213> Homo sapiens


      <400> 1843
 ttttttttgt ctttattcat ttatttattt attcattcat tttgtgccct tctgggaatg     60
 aaccaggact atttgaatgg aaagagaaaa aaaaaaggct gtcataggtt taaaaattgg    120
 catatgttct cttccagatt aaattccctt ggacctttta atttatgcta gaacaagcac    180
 ttatcttttt ttttttttat tactaagccc aacacagtgc gtggcatgca gtaactgttc    240
 aaataatgtt tgtttaattg acgggtttta agctcgataa cttagctaag ccctttgcac    300
 agtctaagcc taatttggaa tgctttcagt cttacccagg ccaataaaat tttcttgcct    360
 catctgaatt tcctgcaaat gtgattaatt aataagaatc atcaagatta attaataaga    420
 aattgatagc aggatgagta acaggcccag acagtcccac agatcacacc ttccgccctc    480
 catttccgct tagcttctct tgaatctatt gggcatgatt gcctctgtgg gggctacagc    540
 cagcatgggt gactgttcat gacctaccct ctcttgcagt ctgactgtgg acaaatgccg    600
 agtccttaag agatggtgaa gtaggcatag tagatagtaa aggtagactt acagtataca    660
 tttgcattct caaacaaaat taaaaagcct taaagtgcac aagaagattg cacaattgaa    720
 aagtgcagag tatactcaaa actgtcatcc tactgttttc tcagtcttcc ctgcaatact    780
 attccctcct cagacatcct cagctccctc tcaccccaag tatgccattg tctttgtaat    840
 tcttattaaa atactaaagc aaaaattcat cgtagaacaa ttcatgtcca caaaggtttg    900
 cctcagttgc tcatgccctg tatgcatttc ctctggtttt attattcaaa ttaagaaaat    960
 acttaaaaat tttttggtaa cagcttgcat gcaaccccta agtgtacccc tataaccctt   1020
 tggctttttt cagagaaaga cttcagccaa attgtccctt tcactcctct gagggcagct   1080
 ctgggaaact ctcctgacca ccttctccct ccttcacgtc atctttgtgt gacagcagga   1140
 catccgggtt tggagcatcc tccaccaccc actgacactc atgaatacgg gctaccttga   1200
 tctcctctgc attcacactg gccgtggcct gggccgcgct gctttgccct cccatctctt   1260
 cttgttcctc agaaacctgg ctctcactga ggcagatggg gtcagaacct aaggtgcagc   1320
 cctcttgctg tgaggcatcc ccttcctcgg tacacttgcc ccctcttcct tcatgggcag   1380
 tgagtgtgca ggcctctcct gggagctccc cctccatggg ccccaggggc tcctcggtga   1440
 gccctccact ggctggcgga gaggctgggc tgcctacctc tggaaatccc cccaactcct   1500
 ccccatgggc ctcgggacag ggaggttggg cctccctctc gctgacttca ctttcttcac   1560
 agttgtcggg gtggatggca gctgcctgac tgggctcttt ttcctcttct tcttcatttt   1620
 cttggggaac gtggctctcc ccattcgtat cttcttccat cactggagca gagtccactg   1680
 gtacttccac ggacgctgtc agcaactttc tgagcgcctt caaagaaccc gaggcagtga   1740
 tgggttctgg ctcttcctgg gcgggttctt catcctcaag ggtccctcca aactccagct   1800
 ctgatgagca tgtgcccggg agtcctgctg tgtcctctgt tgccacagga ttcaccacgg   1860
 ggtcatccac tcttgaaata atcacctgct cagtcccatc tgggggtggg cttggcccag   1920
 ggagagaaag gctttctcct ttggccaacg agctagggac ctcaggctgc ttctcttcct   1980
 ctgactcctg gaatacttcg ttactgaggg tctcactacc cggaactcct ggcagaatgg   2040
 cagaagctct cctggcaggg ctggcctggt ttgaccctgt ggggggcttt agatctgtta   2100
 agctggacac actttcactg ggcaaggcca tgttatcttc aaataagttg tgtttcttca   2160
 agatagcagc ttcctttatc actttcagag tttcatcaag caggatctga tgtaaaatct   2220
 cctcatagac attttcaacg tgaatcatat tggtatgatc tgcaaagatg aactgctcgt   2280
 atttctgaag ctctggtttg catgtggacg ccagtgcctt ctgcacagtg ggaagtgtga   2340
 tttgaactag tgcctcttga aatatcttct ttcggatggt gctgctgtca taatcatatt   2400
 gctttaagac tcggagttta accttctcaa tggcaactgc agttttggag gcctctcctt   2460
 ggagatgtgg ggaaagcaac tgctcaaaag tgaacactgc attctccatt agctcctgca   2520
 tgtagttctg tgtcctctga accaccagat caatgtgggg gaatctgaag cggctcttga   2580
 gatcctgcag gcgctcgtga agcaggttga ctttagtata acaaggttcc atcttcacgg   2640
 aatgcagcgg aagattcata agccggtcta gatgctcctt tagctggaca ctgtctttgg   2700
 tggtctggaa gttctggctg acttcattca cctctttctc aaagagtaca cgtacttcac   2760
 tgaatcccga gctcactggt cccatgagct cctccaggat ggatgccagg aatggctgca   2820
 cactctccaa gcagcttttc tccgccggct gggccaccat cgctttgatc tttccaatta   2880
 aatagttctt tgagttcaca atctgatcca tgtcagaacg gatcgttcct tccaggccct   2940
 ttgtcagagc tctgcattcc tccttcaagg cacttaatcc ttctgaaact tgatgctgaa   3000
 ccagggtgta ggcctcctcg aggagaccaa gccccgccct ctttctgtca ttcttcttcc   3060
 ccttcatctt aggcagcagg tctgtctgaa gagtgggcag gagctcctcc atcaccaggt   3120
 tactcaggat ctggatttca tccccagtga tcatttccca ggaaccatag tgacccttct   3180
 cctgtcggaa gaattgcaca gcttctaaaa aggcctgggc ttcaaatgtc atctgcttca   3240
 tgtaatcatg attgagatgc ctgacgcagt cactcaggag ggcactaaac ctcttctggt   3300
 cagcagcctc gtggaagcag aagtagccgt gtctgaagaa gggctgccac aggtacactg   3360
 ggaattcctt gggcaggacc acaaagggct gagtgttctc cttctcactg gaggcaagag   3420
 ggtctgggaa atgcctgtca gacaacagat tatattcatc ttctgaggtt aacaccttgc   3480
 caccggctgg aagaattcga catttaggag cagctcctct ctgataggcc tgctaatggc   3540
 aaggtaatat tttaatactt tcatgtgaca gtcacaacat ggtaaatcag agtccctaat   3600
 ctcagggaga tttaccctag ttatgttctc gaatgtggaa aacataatct cagtaaccct   3660
 gaaagtctgc accacatttg ccatttcaga tgctaacaac taaatcattc tgataataac   3720
 cacaaaggtg acgatcacac gaattacgcc actctagact aggggtcttc gaa          3773



      <210> 1844
      <211> 1380
      <212> DNA
      <213> Homo sapiens


      <400> 1844
 atgggctcca ggctgctctg ttgggtgctg ctttgtctcc tgggagcagg cccagtaaag     60
 gctggagtca cacaaactcc aaagcacctg atcacagcaa ctggacagca agtgacgctg    120
 agatgctccc ctaggtctgg agacctctct gtgtcctggt accaacagag cctggaccag    180
 ggcctccagt tcctcattca gtattataat ggagaagaga gagcaaaagg aaacattctt    240
 gaacgattct ccgcacaaca gttccctgac ttgcactctg aactaaacct gagctctctg    300
 gagctggggg actcagcttt gtatttctgt gccagcagcg tcaaagtagg caccggggag    360
 ctgttttttg gagaaggctc taggctgacc gtactggagg acctgaaaaa cgtgttccca    420
 cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca    480
 ctggtatgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat    540
 gggaaggagg tgcacagtgg ggtcagcaca gacccgcagc ccctcaagga gcagcccgcc    600
 ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag    660
 aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag    720
 tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga    780
 gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc    840
 tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg    900
 atggccatgg tcaagagaaa ggattccaga ggctagctcc aaaaccatcc caggtcattc    960
 ttcatcctca cccaggattc tcctgtacct gctcccaatc tgtgttccta aaagtgattc   1020
 tcactctgct tctcatctcc tacttacatg aatacttctc tcttttttct gtttccctga   1080
 agattgagct cccaaccccc aagtacgaaa taggctaaac caataaaaaa ttgtgtgttg   1140
 ggcctggttg catttcagga gtgtctgtgg agttctgctc atcactgacc tatcttctga   1200
 tttagggaaa gcagcattcc cttggacatc tgaagtgaca gccctctttc tctccaccca   1260
 atgctgcttt ctcctgttca tcctgatgga agtcctcaaa caccatttcc atacccaggc   1320
 attctgggtc cccactggag ggttagtctg aagggcaatg gctgggcttt ggaaaaccag   1380



      <210> 1845
      <211> 1039
      <212> DNA
      <213> Homo sapiens


      <400> 1845
 tttggggggg cagtatcatt ttaactaggg aggagaggga aggcttccct taagaggtga     60
 tatttcaact caaggatggt aaagagggaa gccacaaaga cactcgaaat aaaggtttca    120
 gggaagggac agacagcagg ggtggcggag aggtgggtgc ggggcaggag ggccatgaag    180
 gcgctcgtgt ctcctgcgag ggctcagggt gctcggcctg tcataaatgg acttaggctt    240
 tgacagagca gtttagctgc cctaaagaaa cctgggaagg ttcccttggc acttgggatt    300
 gtccgtttcc ttttctgtct atgtgcgctg tctatgctgg acttgagata attctccgga    360
 gtccgactca ccaggagact cgggtgtcac ccagattgac cttcaaggct catttcttgt    420
 cagtccagta cccgtcccct cggttcacac gaccatccag aaacctcaaa ttcagtccat    480
 gcttcttgtt ttgggtctcg gggctgggat aaggcggggc tgaccaccgc ggggcatgta    540
 ggtagtttcc gtggtgctgg gggcgctctc cagggaagac tacttggtct gcagaaaagg    600
 ccttgacttg tgcatacctg ggcagcgggc ctatgagtgg cagcgagagc ggggtaacca    660
 gagagggcac accccccaac cggagcgccc cccaggttgg catctccaca actgtagaac    720
 ctcccccatc agggcaaccc tcccgattgg gacaccgccc ccagccagac acatcctcct    780
 agcagaacac ccatgcttag ccggagccgc tcccccgcca gacacctccc caccgggaaa    840
 ccctccccag tgggacaccc cagccagtcc aggtattccc gccgttaggg acaccccctc    900
 cagccggagc ataccctcgg caggggcatt cctctcaacc gagggaacac cgccgcaacg    960
 ggaacctgcc tgaaccagag caccataacg cgccggggac accccacagg cggctcccgc   1020
 gcacgaagtg gtcgatccg                                                1039



      <210> 1846
      <211> 639
      <212> DNA
      <213> Homo sapiens


      <400> 1846
 ctgagactcc agcaggatgt cttatcaaca gcagcagtgc aagcagccct gccagccacc     60
 tcctgtgtgc cccacgccaa agtgcccaga gccatgtcca cccccgaagt gccctgagcc    120
 ctgcccacca ccaaagtgtc cacagccctg cccacctcag cagtgccagc agaaatatcc    180
 tcctgtgaca ccttccccac cctgccagtc aaagtatcca ccgaagagca agtaacagct    240
 tcagaattca tcaggaccaa gaaaggataa ggatatttgg ctcacctcgt tccacagctc    300
 caccttcatc ttctcatcaa agcctaccat ggatacacag ggagcttctt tctccttagc    360
 cagtaatctg cccatgatga tccctgacag caaaaagttt cttttctgag gctgccatac    420
 tgccactgtc caggtggaga ctgagcaaag gaagtcctgg gctgtgccag ctcccagagc    480
 ttcggaagaa agagcagcag ctctctccct gggaaccatc agagaattct gttgatgtgt    540
 tctgtgtctg tctgtcacct ggtcacgagc ttctaccacc tttgcaattg tcacttatct    600
 ttcactccct gaataaagta tctatgcata aaaaaaaaa                           639



      <210> 1847
      <211> 4732
      <212> DNA
      <213> Homo sapiens


      <400> 1847
 gaaaagccaa cgctccacgc ccattttcgt cagggaatat gtacccatcg gctttagata     60
 aataaggaaa cagggggctg aaccagaact aagagaagat tgggcagaga gaaggcaatg    120
 gcgagtccac ctaggggctg gggctgcgga gagctgctgc tgcccttcat gctcctgggg    180
 acgctgtgcg agccaggatc cgggcagatc cgctactcga tgccggagga gctggacaaa    240
 ggctccttcg tcggcaacat agccaaggac cttgggctgg agccccagga gctggcggag    300
 cgcggagtcc gcatcgtctc cagaggtagg acgcagcttt ttgccctgaa cccgcgaagc    360
 ggcagcttgg tcaccgcggg caggatagac cgggaggagc tctgcgctca gagcccactg    420
 tgtgtggtga actttaacat cttggttgag aacaaaatga aaatttatgg agtagaagta    480
 gaaataatcg atattaatga taacttcccg cgtttccggg atgaagagtt aaaagtaaaa    540
 gttaatgaaa atgcggctgc agggacacgg ttagtgcttc ccttcgcgcg ggatgcggat    600
 gtgggtgtga actctctccg gagttaccag ctcagctcca atctgcactt ctctctggat    660
 gtggtaagcg gaactgatgg acaaaagtat ccggagctgg tgttggaaca gcccctagac    720
 cgcgagaaag agactgttca cgacctcctc ctcacagctt tagatggcgg agacccggta    780
 ctctccggca ccacgcacat ccgtgttacg gtcctcgacg caaacgacaa tgcgcccctg    840
 ttcaccccat ccgagtacag cgtgagtgtt ccagagaaca tacctgtggg cactcggctg    900
 ctcatgctaa ccgccacgga tccagatgag ggaataaacg ggaaattgac ctactctttt    960
 cgcaatgaag aagaaaaaat ttcggagact ttccaacttg attccaacct gggggaaatc   1020
 tcaactctac aatcactgga ctatgaagaa tccagattct acctcatgga agtggtagct   1080
 caggatggag gcgctcttgt tgccagcgct aaggtggtgg tcacagtaca ggacgtgaat   1140
 gacaatgccc ccgaagtgat cctcacctct ctgaccagtt cgatctctga agactgtctt   1200
 cccggaactg taatcgcgct gtttagcgta catgatggtg attctggaga aaatggtgag   1260
 attgcatgct ctattcctag gaatttgcct tttaaattgg agaagtcagt tgataattac   1320
 tatcacctat taacaactag ggacctggac agagaagaga cttcagatta taatatcact   1380
 ttaaccgtca tggaccatgg aaccccgccc ctctctacag aaagccacat ccccttgaaa   1440
 gtagcagacg ttaatgacaa cccacccaat ttccctcaag cctcctactc cacctctgtc   1500
 acagaaaaca atcccagagg tgtctctatc ttctctgtga cagcccatga ccccgacagc   1560
 ggcgacaacg ctcgagtcac ctactccctg gctgaagaca catttcaggg ggcgcccttg   1620
 tcctcctatg tatccattaa ctctgacacc ggtgtcctgt atgctctgag atccttcgac   1680
 tatgagcagt tgagagacct acagttgtgg gtgacagcca gcgacagtgg gaaccctcca   1740
 cttagcagca acgtgtcgct gagcctgttt gtgctggacc agaacgacaa tacgcctgag   1800
 atcctgtacc ccgccctccc cacagacggt tccacgggcg tggagctggc gcctcgctcc   1860
 gcagaacctg gctacctggt gaccaaggtg gtagcggtgg acaaagattc aggccagaac   1920
 gcctggctgt cctaccgcct gcttaaggcc agcgagccag gactctttgc ggttgggctg   1980
 cacacgggcg aggtgcgcac agcgcgagcc ctgctggaca gagacgcgct caagcagagc   2040
 ctcgtggtgg ccgtcgaaga ccatggccag ccccctctgt cagccacctt cacggtcacc   2100
 gttgccgtgg ccgacaggat ccctgacatc ctggctgacc taggcagtat caagaccccc   2160
 attgaccctg aggatctgga cctcacactc tatcttgtgg tggcagtggc tgcagtctcc   2220
 tgcgtcttcc tggccttcgt catcgtgctg ctggtgctca gactgaggcg ctggcacaag   2280
 tcacgcctgc ttcaggctga aggcagcagg ttggcgggtg tgcccgcctc gcactttgtg   2340
 ggcgtggatg gggttcgggc tttcctgcag acctattccc acgaggtctc cctcaccgcg   2400
 gactcgagga agagtcacct gatctttccc cagcccaact acgcagacac gctccttagt   2460
 gaagagagct gtgagaaaag cgagcctctt ctgatgtctg ataaggtaga tgcaaacaaa   2520
 gaagaacggc gagttcagca agccccgccc aacacggact ggcgtttctc tcaggcccag   2580
 agacccggca ccagcggctc ccaaaatggc gatgacaccg gcacctggcc caacaaccag   2640
 tttgacacag agatgctgca agccatgatc ttggcgtccg ccagtgaagc tgctgatggg   2700
 agctccaccc tgggaggggg tgccggcacc atgggattga gcgcccgcta cggaccccag   2760
 ttcaccctgc agcacgtgct gcagggtgaa ctggggtccg actaccgcca gaatgtctac   2820
 atcccaggca gcaatgccac actgaccaac gcagctggca agcgggatgg caaggcccca   2880
 gcaggtggca atggcaacaa gaagaagtcg ggcaagaagg agaagaagta acatggaggc   2940
 caggccaaga gccacagggc ggcctctccc caaccagccc agcttctcct tacctgcacc   3000
 caggcctcag agtttcaggg ctaaccccca gaatactggt aggggccaag gccatgctcc   3060
 ccttgggaaa cagaaacaag tgcccagtca gcacctaccc cttccccccc agggggttga   3120
 atatgcaaaa gcagttccgc tgggaacccc catccaatca actgctgtac ccatgggggt   3180
 agtggggtta ctgtagacac caagaaccat ttgccacacc ccgtttagtt acagctgaac   3240
 tcctccatct tccaaatcaa tcaggcccat ccatcccatg cctccctcct ccccacccca   3300
 ctccaacagt tcctctttcc cgagtaaggt ggttggggtg ttgaagtacc aagtaaccta   3360
 caagcctcct agttctgaaa agttggaagg gcatcatgac ctcttggcct ctcctttgat   3420
 tctcaatctt cccccaaagc atggtttggt gccagcccct tcacctcctt ccagagccca   3480
 agatcaatgc tcaagttttg gaggacatga tcaccatccc catggtactg atgcttgctg   3540
 gatttaggga gggcattttg ctaccaagcc tcttcccaac gccctgggga ccagtcttct   3600
 gttttgtttt tcattgtttg acgtttccac tgcatgcctt gacttccccc acctcctcct   3660
 caaacaagag actccactgc atgttccaag acagtatggg gtggtaagat aaggaaggga   3720
 agtgtgtgga tgtggatggt gggggcatgg acaaagcttg acacatcaag ttatcaaggc   3780
 cttggaggag gctctgtatg tcctcagggg actgacaaca tcctccagat tccagccata   3840
 aaccaataac taggctggac ccttcccact acataatagg gctcagccca ggcagccagc   3900
 tttgggctga gctaacagga ccaatggatt aaactggcat ttcagtccaa ggaagctcga   3960
 agcaggttta aggaccaagg tccccttgag aggtcagagg ggcctctgtg ggtgctgggt   4020
 actccagagg tgccactggt ggaagggtca gcggagcccc agcaggaagg gtgggccagc   4080
 caggccattc ttagtccctg ggttggggag gcagggagct agggcaggga ccaaatgaac   4140
 agaaagtctc agcccaggat ggggcttctt caacagggcc cctgccctcc tgaagcctca   4200
 gtccttcacc ttgccaggtg ccgtttctct tccgtgaagg ccactgccca ggtccccagt   4260
 gcgcccccta gtggccatag cctggttaaa gttccccagt gcctccttgt gcatagacct   4320
 tcttctccca cccccttctg cccctgggtc cccggccatc cagcggggct gccagagaac   4380
 cccagacctg cccttacagt agtgtagcgc cccctccctc tttcggctgg tgtagaatag   4440
 ccagtagtgt agtgcggtgt gcttttacgt gatggcgggt gggcagcggg cggcgggctc   4500
 cgcgcagccg tctgtccttg atctgcccgc ggcggcccgt gttgtgtttt gtgctgtgtc   4560
 cacgcggcta aggcgacccc ctcccccgta ctgacttctc ctataagcgc ttctcttcgc   4620
 atagtcacgt agctcccacc ccaccctctt cctgtgtctc acgcaagttt tatactctaa   4680
 tatttatatg gctttttttc ttcgacaaaa aaataataaa acgtttcttc tg           4732



      <210> 1848
      <211> 463
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(463)
      <223> n = a,t,c or g


      <400> 1848
 tttgacacaa aatttaattt aatagaaatt ttgtttgtag ttcttacatt ctcagtgtga     60
 gccaatctgg gacccactgc cccacccaga agtggcccag tcctgggggc aggggagaaa    120
 gggaggggtg aaatgagaag agccccgttc ttcctcagtg ctggggggtt ggagacacca    180
 cccccttctg ctgccctcct ctgggctcca ggaaggagag cagatgaaat ctcaggcctg    240
 tgnngtctcc acaccactgc cccccaggtt ggaggggagc taagagatga gagaagggga    300
 cagatgtcgg gaccaaacat gatgttgtat tctgagtctc cggctatgtg aagctgtttc    360
 ctaatagttt ggaccagaca gacatgcacg gagactcaga atacaacatc atgtttggtc    420
 ccgacatctg tggncctggc accaagaaag ggtttcatgg tnc                      463



      <210> 1849
      <211> 411
      <212> DNA
      <213> Homo sapiens


      <400> 1849
 tgtggttgtg gaagttgcgg tggctgtggt ggccgctgcg gtggtggctg tggtggtggc     60
 tgcagtggtg gctgcggtgg tggctgcggt ggtggctgtg gtggtggctg tggcagctgc    120
 accacctgca ggtgctaccg ggtgggctgc tgctccagct gctgcccctg ctgccgcggc    180
 tgctgtggag gctgctgcag cactcccgtg atctgctgct gccgccgcac ctgcggctcg    240
 tgtggctgtg gctatgggaa gggctgttgc caacagaaat gctgctgcca gaagcaatgc    300
 tgctgctagg cgggcccccg gcctctgggc aggggctgca ggtatctgcc ctgtaggtaa    360
 gactcccatc cttcccatcc tgtctggtct ccccctcctc tgtggtcttg a             411



      <210> 1850
      <211> 2190
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2190)
      <223> n = a,t,c or g


      <400> 1850
 attacgccaa gcttggcacg agggacccct ccaaactgtg tagacatagt ctaaaatgtt     60
 tggagtgtaa tgaagtcttc caggacgaga catcactggc tacacatttc cagcaggctg    120
 cagatacgag tggacaacaa atgaagaaac acccctgccg ccagtgtgac aagtctttca    180
 gctcgtccca cagcctgtgc cggcacaacc ggatcaagca caaaggcatc aggaaagtgt    240
 acgcctgctc gcactgccca gactccagac gtacctttac caaacgtttg atgctggaga    300
 agcacgtcca gctgatgcat ggcatcaagg accctgacct gaaagaaatg acagatgcca    360
 ccaatgagga ggaaacagaa ataaaagaag acactaaggt ccccagtccc aagcggaagt    420
 tggaagaacc agttctggag ttcaggcctc cccgaggagc aatcactcaa ccactgaaaa    480
 agctgaaaat caatgttttt aaggttcaca agtgtgccgt gtgtggcttc accaccgaaa    540
 acctgctgca attccacgaa cacatccctc agcacaaatc ggatggttct tcctaccagt    600
 gccgggagtg tggcctctgc tacacgtctc acgtctctct gtccaggcac ctcttcatcg    660
 tacacaagtt aaaggaacct cagccagtgt ccaagcaaaa tggggctggg gaagataacc    720
 aacaggagaa caaacccagc cacgagggtg gaatcccctg atgggcgccg tgtcagacag    780
 aaagtgcaaa gtgttgcgca aaaacttttg aaactgaagc tgccttaaat actcacatgc    840
 ggacacacgg catggccttc atcaaatcca aaaggatgag ctcagcccga gaaatagcca    900
 cagatgctcc catgaggaaa atccccgtcc cacattggaa taaaaaagac atttttgtta    960
 caaagtttgc cagtataata gagttaacag tactgtctag gctgttgcaa tatattctct   1020
 ttcaatgtac cttccttcac ctcgtcgtat atatcctcga taagtattaa aacagtattt   1080
 gagtttaaaa gagtttgtat atatttaaat gaataacttt ttatactctt tgttacatgt   1140
 ttgtatcagt atttagtgga aaaccatttg agttgttttg ggttagaatt tttctttttg   1200
 tactgtttct ttaaaacaga gttcttagta acaggggcag ttcctgaatt caaataaacc   1260
 attttgtatg tttggatttt gaatgggtta actaattaca ggctaaaata atgccttttt   1320
 tagtgttttt aatttttaga attcactaca taaattgtaa gtaattgtgg gtctcaaaaa   1380
 cactaggaac ttttaagtgt cttagcactt cctcgatgtg cctgccctga gggagtgagt   1440
 tcacatttga gacaactgca ctccagtgtg gacgtgcctt tgtcttcagg ccatgccgaa   1500
 gggtgtttaa agcagtcttg caggtcgctc ctttcccagc cgtggataaa aactgaagct   1560
 aggaatctaa taaggaatgc tgatttcctc agttccattt tgaggaatgg ggaaggctat   1620
 tctaaagaaa aaaatgggat ttgttttctc ggcagatctg caaggctggc tttaagagca   1680
 caaggaggga aagtaacgaa agggctggac tactataaaa gttacaaata cgtagttaga   1740
 ccaatagatt tatatagtca ggtttttgtc atgtaattta ttaactaact attacagaaa   1800
 cacagctaag aatatcaagt atttctctgg ctcttgacag aaaaaaatca gttgacttaa   1860
 ccctttgctg tcaaaagagt tggcgtttcc tgttctgggt gctactgcca aacgttatgg   1920
 tacttagagt cgggatgcac aacttcaacc accgacttat caatgcagcc gcctgtgtat   1980
 tgcaattggc cgttacctta agcactgagc cacccgggtt tagttcagcc atttcaagag   2040
 tacatttaac gtcggcagtt ctgctttact aaaatgcagt agaggtactc ttctgtccct   2100
 tccgtttata gttctctgag agagttatat tttttggttt tgtttgtgtt tcttttgaat   2160
 tnatatctgt attatcctga acatgtttga                                    2190



      <210> 1851
      <211> 4175
      <212> DNA
      <213> Homo sapiens


      <400> 1851
 tttcgtgccg agcccagctg atgcaacctg gctggactcg cgtgacagtt cccggcacgc     60
 ggcggcgacg gtgacccagg aaggggctct ggtgccgggc tgagcggggg aagcaggggt    120
 agcggagcca tgggggacgc tcccagccct gaagagaaac tgcaccttat cacccggaac    180
 ctgcaggagg ttctggggga agagaagctg aaggagatac tgaaggagcg ggaacttaaa    240
 atttactggg gaacggcaac cacgggcaaa ccacatgtgg cttactttgt gcccatgtca    300
 aagattgcag acttcttaaa ggcagggtgt gaggtaacaa ttctgtttgc ggacctccac    360
 gcatacctgg ataacatgaa agccccatgg gaacttctag aactccgagt cagttactat    420
 gagaatgtga tcaaagcaat gctggagagc attggtgtgc ccttggagaa gctcaagttc    480
 atcaaaggca ctgattacca gctcagcaaa gagtacacac tagatgtgta cagactctcc    540
 tccgtggtca cacagcacga ttccaagaag gctggagctg aggtggtaaa gcaggtggag    600
 caccctttgc tgagtggcct cttatacccc ggactgcagg ctttggatga agagtattta    660
 aaagtagatg cccaatttgg aggcattgat cagagaaaga ttttcacctt tgcagagaag    720
 tacctccctg cacttggcta ttcaaaacgg gtccatctga tgaatcctat ggttccagga    780
 ttaacaggca gcaaaatgag ctcttcagaa gaggagtcca agattgatct ccttgatcgg    840
 aaggaggatg tgaagaaaaa actgaagaag gccttctgtg agccaggaaa tgtggagaac    900
 aatggggttc tgtccttcat caagcatgtc ctttttcccc ttaagtccga gtttgtgatc    960
 ctacgagatg agaaatgggg tggaaacaaa acctacacag cttacgtgga cctggaaaag   1020
 gactttgctg ctgaggttgt acatcctgga gacctgaaga attctgttga agtcgcactg   1080
 aacaagttgc tggatccaat ccgggaaaag tttaataccc ctgccctgaa aaaactggcc   1140
 agcgctgcct acccagatcc ctcaaagcag aagccaatgg ccaaaggccc tgccaagaat   1200
 tcagaaccag aggaggtcat cccatcccgg ctggatatcc gtgtggggaa aatcatcact   1260
 gtggagaagc acccagatgc agacagcctg tatgtagaga agattgacgt gggggaagct   1320
 gaaccacgga ctgtggtgag cggcctggta cagttcgtgc ccaaggagga actgcaggac   1380
 aggctggtag tggtgctgtg caacctgaaa ccccagaaga tgagaggagt cgagtcccaa   1440
 ggcatgcttc tgtgtgcttc tatagaaggg ataaaccgcc aggttgaacc tctggaccct   1500
 ccggcaggct ctgctcctgg tgagcacgtg tttgtgaagg gctatgaaaa gggccaacca   1560
 gatgaggagc tcaagcccaa gaagaaagtc ttcgagaagt tgcaggctga cttcaaaatt   1620
 tctgaggagt gcatcgcaca gtggaagcaa accaacttca tgaccaagct gggctccatt   1680
 tcctgtaaat cgctgaaagg ggggaacatt agctagccag cccagcatct tccccccttc   1740
 ttccaccact gagtcatctg ctgtctcttc agtctgctcc atccatcacc catttaccca   1800
 tctctcagga cacggaagca gcgggtttgg actctttatt cggtgcagaa ctcggcaagg   1860
 ggcagcttac cctccccaga acccaggatc atcctgtctg gctgcagtga gagaccaacc   1920
 cctaacaagg gctgggccac agcagggagt ccagccctac cttcttccct tggcagctgg   1980
 agaaatctgg tttcaatata actcatttaa aaatttatgc cacagtcctt ataattggaa   2040
 aaatactggt gcccaggttt tcttggagtt atccaagcag ctgcgcccct agctgggatc   2100
 tggtacctgg actaggctaa ttacagcttc tccccaacag gaaactgtgg gatttgaaaa   2160
 ggaaagggaa gggaaaacag agaacctagt ggtctaccaa gtggttggca actttcccaa   2220
 tgtctgctta ctctgaggct tggcactggg ggccagggcc tgccccaggg ctcctggaat   2280
 ttcccttgat ccagctaggc tgggacactc cctaaatcag ctgcgtgttg ttagcatcag   2340
 gcagaatgaa tggcagagag tgattctgtc ttcatagagg gtggggtact tctccataag   2400
 gcatctcagt caaatcccca tcactgtcat aaattcaaat aaaatgtctg aacaagggtg   2460
 tctggatgtg agctggacca tctcaggaga gaacacaagt gtgaggcagc tgctggcccc   2520
 tcacctagtc tggggttcct ttaccctgta atggggggtg gggggtagaa gatggacaag   2580
 acaccttaac agtccctttg gcagtactag gcagaagagg cccatacttg ggtccaatgt   2640
 gtgcagcagg caaaacattt tcccttctaa atgtgggccc agaccactgc cctgtccccc   2700
 caacattaag aagcagtagc cacagccaag tttcaatcat ttaattaaca tctttaaatg   2760
 aaacacagtt ttcttcatgt gtctcactca ggcttcaggg cagagggaat ggatttttag   2820
 acatatcaaa gactcaaaaa tttaaagaaa tatatatatg tatatatata cttctaacat   2880
 tttatggaaa ttaaaaatca gaggcttttg gtctctccat ttactctagg tcaagctcat   2940
 ttaccccaga ggacaaagaa gggctgcctc ttctagaccc tcccttctcc tttgtcctct   3000
 gtcccaccca gcagggaaac caagctcaga agatcctaac aggatagagt tccagtaatg   3060
 ttggaggagg gagagggaaa gagaagtcag gttctctccc acctccagcc attcccaggt   3120
 tgctgccagg gcctggtttc atgcagcttt gacccagtcc tggatcctag ggggtggggt   3180
 agatcaggag ctctgagcag aacagtgctc actgattatc ctctttcccc aactcagtgg   3240
 gcaggtgcag cgtacaccca gcagcactct ccactgccca caggcaaggg aagaatattg   3300
 attgattagc tacaaggaga agacagtagt gactagtgga aaacaccctg gagagggcca   3360
 gaggaacctg gctctcacca catcccctct gttcccagcc ttggtgaggg ggcggggagg   3420
 tcatgtcaac ctctctcctt ggtggtgaag ctaaaagcaa ggttccttgc cagactcaag   3480
 cccaagtcac tgttaaggaa agaggatcaa gaaagaagcg gtggccctgg ggggcagcca   3540
 cgctgctgtg gacccacagg ggccaatggg gaagccagct tgcctagaca ggtggcacag   3600
 gctgaaaata gaaaggttaa cattcccgga gagtacagta agagaggctg atacctaggg   3660
 gaccaccacc cagcctgccc tagaagcact gggtgcccct cattgactag agaagacttg   3720
 agtaaaatgc acctgtggct tcccatcctt gtcactcagc gttagctgcc cccagtggaa   3780
 ccacctgtgc tgaaaggcag ctgcagaaag gacatgcacc gaaatgagga gagagaaagg   3840
 tcagagaatg aagtgtggag ggccaggcct gggcccactg ctcaaggaag ctccccccct   3900
 ccagatgctc ccttccatcc acctcctcag tgcttgctca gcccaaaggc tcctgcctct   3960
 gaagtgctgg gggcccaccc accccagtgt ggtcaaggag gcaaggggca ggtgcttgac   4020
 actgccaagt gccccgagat gactctactg ctcacccatt tctttgggcc ctggcagtct   4080
 cctacttgtc cccagcatgg agcacctggc agaactggaa ggcaggaggg tggttggtga   4140
 gttgaggcac aggaaggcca atcccctctc gtgcc                              4175



      <210> 1852
      <211> 711
      <212> DNA
      <213> Homo sapiens


      <400> 1852
 tttttttttt ttcagttaag gcaggaggga atttagtcgg agctggggaa ggaagaaagt     60
 ggggttggga gaacctcccc aaccccatcc cttcctggcc cggggacgcg aattcggctc    120
 tcagcaagag aagtattccc cgggatgctg agcgcttcat tctgtctcca agaactcaag    180
 gcaaggtagg tccccagtcc gccgcgcccc cgggacctac aggtcaagcg tggtccgaaa    240
 gtttcctctt gggggttcgc gggcgcccac acgtactcgg ggggcacctg cgcgtcgggc    300
 gccgccttgc ggtagaagcc gagctcctgc actagcgcat tgatctcttc gcgggtcatt    360
 tcactgagtg ggatgcgctc tagttcctcg tagcggcggc ccagcagcac gagctcaggg    420
 tcggccccag ggaggtgttt catcaccagg ttgtgataga atggaatgtc ctgcgtgacg    480
 aaagccttca cctcctttag gcggttcagc tgtcatcccc cgcaggtctc tacccgggcg    540
 cgggttaggc cgctcagacg gttccagtcc ggccggtagg cagtggcggc tgtggctggg    600
 gccacaagcg ccgcgagaag cagcagcagc gccagcggag gcaacaggag gctcatcggg    660
 acccggccgc agatgatgcg caagctggag gcgaacctcc gagtcgctgc g             711



      <210> 1853
      <211> 411
      <212> DNA
      <213> Homo sapiens


      <400> 1853
 cagtgttttc tttttttaag cttggatatt ttttacttta aaaattgatt ttactgaaaa     60
 ttcaatactt caacctgtta atgaaatgtt gttttagaat caaagggaaa cttgaagaac    120
 agagaccaga aagagtaaaa ccttttatga caggggctgc agaacaaatc aagcacatcc    180
 ttgctaattt caaaaactac caggtaaata ccttaagtat ctggatcaaa ggattgtaca    240
 attttaactg caagagcaaa aattaagttg attaatcttc aattctatac tagtattcca    300
 ggtgtagaaa gtggctttcc cagctcgcag gtgtttccaa atcttgtctt ctgattgaaa    360
 atttgcttcc cagatgacat ttctcagttt ttctttttgt gaattgctta a             411



      <210> 1854
      <211> 664
      <212> DNA
      <213> Homo sapiens


      <400> 1854
 actgattgcc gggtcgaccc acgcgtgcgc ccacgcgtcc ggcagagcac agcatcgtcg     60
 ggaccagact cgtctcatgc cagttgcagc cttctcagcc aaacgccgac caaggaaaac    120
 tcactaccat gagaattgca gtgatttgct tttgcctcct aggcatcacc tgtgccatac    180
 cagttaaaca ggctgattct ggaagttctg aggaaaagca gctttacaac aaatacccag    240
 atgctgtggc cacatggcta aaccctgacc catctcagaa gcagaatctt ctagccccac    300
 agacccttcc aagtaagtcc aacgaaagcc atgaccacat ggatgatatg gatgatgaag    360
 atgatgatga ccatgtggac agccaggact ccattgactc gaacgactct gatgatgtag    420
 atgacactgg atgattctca ccagtctgat gagtctcacc attctgatga atctggatgg    480
 aactggtcac tgattttccc acggacctgc cagcaaccga agttttcact ccagttgtcc    540
 ccacagtaga cacatatgat ggccgaggtg atagtgtggt ttatggactg aggtcaaaat    600
 ctaagaagtt tcgcagacct gacatccagt accctgatgc tacagacgag gacatcacct    660
 caca                                                                 664



      <210> 1855
      <211> 348
      <212> DNA
      <213> Homo sapiens


      <400> 1855
 ggcacgagga tacacgcacg cacttaaaag agagcatgtg gcatgttcat tgtggaacac     60
 aatatgaata cagggcatgc attttgcagc agggagactg tccacaaaaa ccttttgtac    120
 cggtcacggg agccctgtgg acatctgcac agccaagccg cgggacattc ccatgaatcc    180
 catgggcatt taccgctccc cggagaagaa ggcgactgag gatgagggct cagaacagaa    240
 gatcccggag gccaccaacc ggcgtgacgt ggaaccgacc aaggccaatt cccgctttgc    300
 taccactttc tatcagcacc tggcagattc caagaatgac aatgataa                 348



      <210> 1856
      <211> 5214
      <212> DNA
      <213> Homo sapiens


      <400> 1856
 acggccgccc cttttttttt tttttcacag ttccattttt aatgtttaaa tttcatttca     60
 aaaagcaggt ctgtagtttg taaccatgac aattaaaatc tgtgctaatg cacggcagtc    120
 tataacaatt ctacaagcca atcagacagt acgtgacatt tcaatgagta aaaaagagca    180
 taaaactgta tgtgtaagaa caaaatgtta aaaggcctac cacaataata aaaaaccgtc    240
 aattacatca tcacattaaa ataagccaga tgtacaaaag tctgagacag agaagacaaa    300
 aggacaacac aagatatttg ttgaaaaatg tttgtgctct ttgggcactt aattaaacat    360
 tgcaaaatca acatcatctt cttcttcatc agactctgca aaatatttta cttctttcct    420
 agcccgaccg gttcgtggca gagaaggtgg ctcagtaggg aagtctgagg ggaagatgtc    480
 cacatctgaa tcctgatcaa aagatgtctt cttcggtttc ttgcttgttg ttttggatgt    540
 tttcctgcca gggttataat cgccttcatt ttcagagcca gatgctttcc ttttctttgc    600
 ccctcggcct ttaccttttg gtgttgtagt cttctttgga atgccaaatt ctgaatccga    660
 gtcagagttt acagcctcta ctactttctt ctgttttggg gctctcttgg gcttagggac    720
 tgtatctgaa gacggttttc cctttttagc agctaccgtt ttacttggaa ctttatctgt    780
 ctgtttcaga ccaaatgatg gtgaaaaaac agaagcagaa tcttcttcat tactgtcaaa    840
 tttagctgaa tcatcttctg acttctgaga atatgaagga aatgagaaga gatttccaaa    900
 atcctgactt tttttgtcat gcaaagattt ttctggagtg gcttttgatt tgcctggtga    960
 aaatgtatat tcatctttat ctaacccatc tgaaggaaca aattcatctt ccccatcatt   1020
 tgttatggga gatgctttaa ctttcaattc ctctaaatca ttattgtcat catcatcatc   1080
 atcagcatca tcatcctctt cttctgagaa atcaaatgtg tatttaggtc tttcggctgc   1140
 tgctctccta agcaaagaat ctcttggaat aaccacaggt tctgtttctt ccaaatcact   1200
 ttctgacttg gattcatcat ctgaccaagg attccgtttc ttcactttct ttgcactagg   1260
 tttaccagat gatgtaggtg tttttctcac tctggtacca ggctccttct tctccctctt   1320
 aggtttggga cctttattta taggaactga tggagtcaat gcctcttctc ctgcaccttc   1380
 tactggtgct ccactgaatt cttcatcaaa ttccactttt actgctgcag tatcaagatc   1440
 acccttcttc ttcttcagca actttttgct ggcatctgcc ttcatagctg taatttcagg   1500
 aattattctt ctgccataag gtgagggcat tgtctcttcc aactggagtt tcttcacctt   1560
 aggtttgcca actttacctt taattgcttt tccagacatt ccagccagaa catcttctcg   1620
 ttcttgagat tccactttat ccagttcttc aacaaatgcc gctaaatcct ctttccaaag   1680
 atctgaagga gattttcttt taagatcatt gacctctcgc ccttttgcat ctctctgttt   1740
 aatcagttct tcaacttttt ctttagtaag agaccacaga gacatattta aaatataatt   1800
 aaaatctggg cctgaaggag ttcctgaatc ggaggaacta tcatcatgct ggttttgtgt   1860
 ttcatcctct tctgctgcct tttcttgtgc ttctttccag gctttcactg ggtcagattc   1920
 ataacctctc tggactaaca tttgaatcaa atctttcttt gacctattct atatagtaat   1980
 tttcccttgt atcttctcta aaatgaaacg ggcttgattg ttaagcttcg taaattctgc   2040
 tcccaacatt cccacaagcc actccttacg taacccgtaa taacttaatc gtaaatcaaa   2100
 gaattctttc agaatgtctt gcacagtttc atatttcttc agacatccca tatgatcaaa   2160
 aagtaccatg gaattacaag taagagtagt ttgaagttta aaaactttat gcagtccagc   2220
 agcttctgct tgtgctagtt tctcttcagt cattttcacc acaaatttca cagttgtgtc   2280
 agtatgatat tctttataat cagaaattaa tgctggtgtt ttatctgttc catttagcat   2340
 aggttctaaa acctgttctt tatatacctg tgtccaagtt ctaactggaa gctctgtaat   2400
 ttctactgtg tttctgtcca ctacaaatat ttcaccactg actgcatact ggttttgacc   2460
 aagttcttga atcgtgcctt taaagttttt gtagtttgga agcatgggat gaggatccag   2520
 gccatctagc attcgtctga cattgttcac aatttcccta gcatcatagt tgggtagttt   2580
 acaagcccat ccagtaccaa tgccctcagc accatttatt aaaaccatgg gaattatagg   2640
 aatataccac tcaggctcta cacgttgatt atcatcataa aggaacttaa ggaggttgtc   2700
 atccacagca ggaaaaagta gccttgctaa agtgcttaac attgtgaaaa tataacgagg   2760
 gcttgcagca tctttgccac catgaagccg agttccaaac tgaccaatag gctgaagcaa   2820
 gttaatgttg ttacttccca caaagttctg agccaaattc acaatagtca tcatcaatgc   2880
 ttgttctcca tgatgataag ccgacatctc agcaacagag ccagccaact gggcaacttt   2940
 tacttcacgt ttatcattcc tcttgaaaca ggtaaataaa actttccgct ggccaggttt   3000
 aaagccatca acaagagatg gtatagatct ttcattgtct gagtttgaga agagaatcaa   3060
 ttccttgttg atgaaatcat tataagtcaa atgctttgtt gcagtaccat ataaaaattg   3120
 ctctggtaag ccatgtagcc tacgctgtct ccggtcttcc ataaaatttg ttaaccattc   3180
 ttttctgtca tcaatcttct tcttactaaa tgccaaggta atggcagcat catcttcagg   3240
 accagcatat ctaaacaaga tgcgatgcct ttccatatca gcaaaatatt cctttgcttc   3300
 tttagctgta ctagtaccca atcctttata gtactttatt ttccaggctt tctggttttc   3360
 tatatgtttt ttccattcgt caaattcagg aatactgtag aaggaaagtt cctgcttatt   3420
 tttgcttgcc tttacaatag gagtaatgaa ctcttcaaga aaaccatgct tcaaaagtga   3480
 tggccaattg tgatggatga aattaataag caggcctttt atgtgagaac catcttgatc   3540
 ctgatcggtc ataatcataa tctttccata gcgtaaggtt ttcagagatt gtgcatcatc   3600
 gtaacttttc ttatattgta gaccaactat tttaataata ttatttattt cagcattttc   3660
 catgatctgt ttatgagaag cttcccgtac attaagaatt ttgcccctga gtggaaaaac   3720
 tccgtatctg tctcgtccaa tcacacctaa tccagacaca gccagtgatt tggcagagtc   3780
 tccctctgtt aatatcagtg tacactccag ggaatgttta ccaccagcat cattagcatc   3840
 atccagtttg ggaatacctt tgattttact gtattttact gatgaacact tcttattcag   3900
 ctgagtctga gccttaaatt tcacccagtt caggatactt tctacaatgc cacaattaga   3960
 ggctgcttta aaaaattttt ctgacagctg gcatttagac ccaaaacttt tgggctgcag   4020
 agtcatgttt tccttagtct gagaatcaaa agttggattt tcaataaggc aattaataaa   4080
 aacccatata tggtttttta cttgaaatgg tttcactgat acaccagctt tgttcttttt   4140
 cttaactact tcaatcagtt taccaacaac ttgatctacc acataatcca cgtgccgtcc   4200
 accttttgta gttgcaatac tatttacaaa gctgatttgc tggaatcctt tttcactcaa   4260
 tgtgagacaa acatcccatc tttcatttgc aagctcatga ataactttca gggccacccc   4320
 agtttcatcc aatttgtctt tcacataaag atctacataa ctgcgaaatc catttacagg   4380
 caatttcttt ccattaaaca tgaccttgac ccctctacac gaaccagcca aatcatatgc   4440
 ccttctagtc atgagggcca caatatcctt gtcaagtttt tccatcttaa atttggacag   4500
 atctggttgg aatgttatgc atgtgtaatc ttcaccatca aaatgtttaa ttttggcttc   4560
 agaagtcttc atcatattat tcatccatgt ctgcttaaaa ctgtgtttgt attctttgca   4620
 agctgtttct actgtaaact ttgtactgaa aatattacaa agttttgcac cataaccatt   4680
 acgaccacct gtaacttttt tctcatcatc atcatagtta ctggatgtta aaagctgtcc   4740
 aaaaattaaa gcaggaacat aaactttctc caccttgtgt tctactactg gaatgccttt   4800
 cccattattc caaatgctta taatgttaga ttcaggatca atagaaactt taatacaagt   4860
 catgttctta tccctctgtt tattgtcagc agcattaacc aaaatttcat caaagatctt   4920
 gtataaacct ggcacaaagg taacctccct gcaattcatt cctacatctt catcatacac   4980
 ccacatgaac tgcgtcaatg gctccactga cccaatatat gtatcaggac gaagaagaat   5040
 gtgttcaagt tgtgtcttct tctgatacac tctctcaaca gacaacttct ttgaagaatc   5100
 atttttgttg gcagtttctg actcttcttt ttttgcagca ttgttcaccc aggtcagtgc   5160
 cccgttgccg ccgcccacgc cggctcccgc gccgcagcca cccgacttgg ccat         5214



      <210> 1857
      <211> 417
      <212> DNA
      <213> Homo sapiens


      <400> 1857
 cttcaagatc cagaagacga ggctgcagcg agagggcttt gacccacgcc agacctcaga     60
 ccggctcttc ttcctggacc tgaagcaggg ccactacctg cccttaaatg aggcagtcta    120
 cactcgcatc tgctcgggcg ccttcgccct ctgaagctgt tcctctactg gccacaaact    180
 ctgggcctgg tgggagaggc cagcttgagc cagacagcgc tgcccagggg tggccgccta    240
 gtacacaccc acctggccga gctgtacctg gcacggccca tcctggactg agaaactgga    300
 acctcagagg aacccgtgcc tctctgctgc cttggtgccc ctgtgtctgc ctcctctccc    360
 tgcttttcag cctctggctc cttccatccc tgtccctgtc tggccttaac tcttccc       417



      <210> 1858
      <211> 765
      <212> DNA
      <213> Homo sapiens


      <400> 1858
 ctccccgtga agtcccatac tacacaatat tcatctggtg ttgttgccta gagtttgtcc     60
 cagcggaggg ttggcttcgg atctgcagag gctttaggga cctgctccag ccactgaaca    120
 cactagccgt ctgagacggc agctgagttg cactgtgcga cgcgacagag actacatttc    180
 ccagcattcc agcggcgcac tcgggggacc acagatccca gcgcaccaca gatcccagcg    240
 caccacaaag aggcccgggg actacaaatc ccagcatccc ctgcactcgg ttcctctgta    300
 acttagactc cagtgtgccg cgcagtgtgc gcaaattcac aaacccgccc gctgagttgg    360
 tcgtttcgga atcccgagac ttgaaaccca acgggaagac ccttctcacc ctcaaaagaa    420
 gatgacagcc cgcagagagt taacttctgt ttacatggaa ctcagacatc tgcaaatcat    480
 gatttcaagg ccagagaatg gcaggggaac agaaaccctc aagtaatctc ctggagcagt    540
 ttattttact agccaaaggt accagtggct cagccctcac tgctctcata agccaggtct    600
 tagaggctcc cggagtgtat gtctttggag aacttctgga gctggccaac gtgcaggagc    660
 ttgcggaagg agctaatgct gcttatttgc agttgttgaa cctgtttgcc tatgggacat    720
 acccagatta catagccaac aaggagagcc tgccagaact gtatt                    765



      <210> 1859
      <211> 422
      <212> DNA
      <213> Homo sapiens


      <400> 1859
 gtcggtgaga atccagggag aggagcggaa acagaagagg ggcagaagac cggggcactt     60
 gtgggttgca gagcccctca gccatgttgg gagccaagcc acactggcta ccaggtcccc    120
 tacacagtcc cgggctgccc ttggttctgg tgcttctggc cctgggggcc gggtgggccc    180
 aggaggggtc agagcccgtc ctgctggagg gggagtgcct ggtggtctgt gagcctggcc    240
 gagctgctgc aggggggccc gggggagcag ccctgggaga ggcaccccct gggcgagtgg    300
 catttgctgc ggtccgaagc caccaccatg agccagcagg ggaaaccggc aatggcacca    360
 gtggggccat ctacttcgac caggtcctgg tgaacgaggg cggtggcttt gaccgggcct    420
 ct                                                                   422



      <210> 1860
      <211> 446
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(446)
      <223> n = a,t,c or g


      <400> 1860
 tttcgtcggc ggccacggaa gcggccaagg gggcggtggc gcaaagaggg gtgcggagcg     60
 ggcggaagag gcgtctgtgt cgcagcttgg tctcagagga gcatcgctgg gaacaacgac    120
 tatcgtctat tccacaagat gagtaacagc caccctcttc gcccctttac tgcagtgggg    180
 gaaattgatc atgtgcacat tttgtctgaa catatttgtg ccttgttgat tggggaagaa    240
 tatggcgacg tcacattcgt gggggaaaag aaacgttttc ctgcccacag ggtaatttta    300
 gcagccaggt gccaatattt tcgagcatta ttatatggtg gaatgcgaga gtctcagcct    360
 gaagcagaaa ttcctctcca agacaccact gcagaagcat tcacaatgct actcanatat    420
 atctacactg ggcgggcaac gctgac                                         446



      <210> 1861
      <211> 436
      <212> DNA
      <213> Homo sapiens


      <400> 1861
 gtcggaaaat ccgcgagccc cacgcgtccg gcttgaggac accttgacta acctccaagg     60
 gcaactaaag gatcaagaaa ggcccagcac agcagaagat cagctggatc tagctcctgc    120
 aggagatgtg tacaaagaca atcccagtcc tctggggatg tttcctcctg tggaatctct    180
 atgtctcatc ctctcagacc atttaccctg gaatcaaggc aaggattact cagagggcac    240
 ttgactatgg tgttcaagct ggaatgaaga tgattgagca aatgctaaaa gaaaagaaac    300
 tcccagattt aagcggttct gagtctcttg aatttctaaa agttgattat gtaaactaca    360
 atttttcaaa tataaaaatc agtgcctttt catttccaaa tacctcattg gcttttgtgc    420
 ctggagtggg aatcaa                                                    436



      <210> 1862
      <211> 436
      <212> DNA
      <213> Homo sapiens


      <400> 1862
 gtcggaaaat ccgcgagccc cacgcgtccg gcttgaggac accttgacta acctccaagg     60
 gcaactaaag gatcaagaaa ggcccagcac agcagaagat cagctggatc tagctcctgc    120
 aggagatgtg tacaaagaca atcccagtcc tctggggatg tttcctcctg tggaatctct    180
 atgtctcatc ctctcagacc atttaccctg gaatcaaggc aaggattact cagagggcac    240
 ttgactatgg tgttcaagct ggaatgaaga tgattgagca aatgctaaaa gaaaagaaac    300
 tcccagattt aagcggttct gagtctcttg aatttctaaa agttgattat gtaaactaca    360
 atttttcaaa tataaaaatc agtgcctttt catttccaaa tacctcattg gcttttgtgc    420
 ctggagtggg aatcaa                                                    436



      <210> 1863
      <211> 436
      <212> DNA
      <213> Homo sapiens


      <400> 1863
 gtcggaaaat ccgcgagccc cacgcgtccg gcttgaggac accttgacta acctccaagg     60
 gcaactaaag gatcaagaaa ggcccagcac agcagaagat cagctggatc tagctcctgc    120
 aggagatgtg tacaaagaca atcccagtcc tctggggatg tttcctcctg tggaatctct    180
 atgtctcatc ctctcagacc atttaccctg gaatcaaggc aaggattact cagagggcac    240
 ttgactatgg tgttcaagct ggaatgaaga tgattgagca aatgctaaaa gaaaagaaac    300
 tcccagattt aagcggttct gagtctcttg aatttctaaa agttgattat gtaaactaca    360
 atttttcaaa tataaaaatc agtgcctttt catttccaaa tacctcattg gcttttgtgc    420
 ctggagtggg aatcaa                                                    436



      <210> 1864
      <211> 1057
      <212> DNA
      <213> Homo sapiens


      <400> 1864
 gagaagaaga acaggaatgc agaccagcca ttaaaacatc agatatcgac aatcctagcc     60
 actttgaaaa gcaatatgaa tctagttctt ctagcactca cagtgatagg agcagtgacg    120
 gtgagcaaga ctttgtttcc tccattctac caggaaacag accaaattca acaaatatta    180
 aaccacagct gcaccaaaaa agcataatga aaaagaaagc tggtcacaaa gctaactcca    240
 aacactaaga ctaagaacag acagtagtag atgtcactga gcagttaggc gattgcaaat    300
 tagatagtca ggagaaagat gctacatgtg aacttccttt acagaaagta aatactcaga    360
 gttcttcaaa tagcactttg cctggaagat taaaagcgtc agaaaattct gaaagtgaat    420
 acagtaggtc agaaataact ctagtaggca taagtaagaa aagtgcagag cattttaaga    480
 gaaaatttgc caaatcaaac caagtgtcta ggtcagtgtc tagttcagtg caggtgtgtc    540
 ctgaagttgg aaagagaaac ttacttaaag ttttgaagga gactttgatt gagtggaaga    600
 cagaagaaac attgaggttt ttgtatggcc agaattatgc ttctgtgtgt ctgaaacccg    660
 aagcctctct ggttaaagaa gaacttgatg aagatgacat aatctcagat ccagatagtc    720
 atttccctgc ctggagggaa tctcagaaca gcttggatga gtctttacct tttaggggct    780
 caggtacagc cattaaacca ctgccaagtt acgagaattt gaaaaaagaa actgaaaagt    840
 taaatctgag gatcagggag ttttacagag gacggtatgt tttgggtgaa gaaaccacca    900
 aatcacaaga ctcagaagag catgattcca cctttccact gatagactca agttcccaga    960
 accagattag aaaacgcatc gtacttgaaa agttgagtaa agtgttgcct gggcttctgg   1020
 ttcctcttca gattacattg ggagatattt acacaca                            1057



      <210> 1865
      <211> 507
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(507)
      <223> n = a,t,c or g


      <400> 1865
 tttcctgctt ttgctcaaat acaatgccgc tgctcatgcc ctgagtgcat ctgtcagcat     60
 atggcagttt ttgagcaaaa gcaggaaaaa aaccaaacag gaaaacaaat ttggaaagcc    120
 caggccataa aattatgtat atcaaaataa aaccaagaag ctttgggatt attcacaatc    180
 ttccttctaa acctggccct cttttcctgc ctcattcact cattgggtgg tttgacttca    240
 ctgctagttt cctctacccc atgaactgct ctgccatgca tcatanggta aggaaaagca    300
 gcagtgccac agccataacc aagatcggca agacgggata gagctttaat gctacctgga    360
 ggtctgcctg ggctgacttt gtatcccgca gctttagttg tccccaaagg tctgcctgga    420
 cttggtggtt cccgaaggcc ggccacgctt accagatcgg ttgagattct tctttttctt    480
 tagttcatct tttatttcta tgcttct                                        507



      <210> 1866
      <211> 395
      <212> DNA
      <213> Homo sapiens


      <400> 1866
 agctgttccc cccggccagc gcagcagggc agccggaccc cagacccaca gtgagtgccc     60
 atgtcttaaa caaacccccg cctcaggctc tgacactgcc accttccaat cctgcccccc    120
 ttcaccttgg ccacgggcct cgatcattgg ccttagtcaa actgcaggtc ttctctttgt    180
 gtccctgagt caggcaggga gacctggaga ccctaaggcc caagtggggt gagttggagc    240
 ctggcgccct ggccctcaag ctgacgcctg tgtgacgggc tctttcccca gcaggatcct    300
 gcagcccccg ctccgtgtga ggagacccag ctctccttgc tgccacttca ggggtgcggc    360
 ctgatggagg ggaagacgat ggaggcgaag accac                               395



      <210> 1867
      <211> 1790
      <212> DNA
      <213> Homo sapiens


      <400> 1867
 cggttgacgt ttgctgattt ttgactttgc ttgtagctgc tccccgaact cgccgtcttc     60
 ctgtcggcgg ccggcactgt agattaacag gaaacttcca agatggaaac tttgtctttc    120
 cccagatata atgtagctga gattgtgatt catattcgca ataagatctt aacaggagct    180
 gatggtaaaa acctcaccaa gaatgatctt tatccaaatc caaagcctga agtcttgcac    240
 atgatctaca tgagagcctt acaaatagta tatggaattc gactggaaca tttttacatg    300
 atgccagtga actctgaagt catgtatcca catttaatgg aaggcttctt accattcagc    360
 aatttagtta ctcatctgga ctcatttttg cctatctgcc gggtgaatga ctttgagact    420
 gctgatattc tatgtccaaa agcaaaacgg acaagtcggt ttttaagtgg cattatcaac    480
 tttattcact tcagagaagc atgccgtgaa acgtatatgg aatttctttg gcaatataaa    540
 tcctctgcgg acaaaatgca acagttaaac gccgcacacc aggaggcatt aatgaaactg    600
 gagagacttg attctgttcc agttgaagag caagaagagt tcaagcagct ttcagatggt    660
 attcaggagc tacaacaatc actaaatcag gattttcatc aaaaaacgat agtgctgcaa    720
 gagggaaatt cccaaaagaa gtcaaatatt tcagagaaaa ccaagcgttt gaatgaacta    780
 aaattgtcgg tggtttcttt gaaagaaata caagagagtt tgaaaacaaa aattgtggat    840
 tctccagaga agttaaagaa ttataaagaa aaaatgaaag atacggtcca gaagcttaaa    900
 aatgccagac aagaagtggt ggagaaatat gaaatctatg gagactcagt tgactgcctg    960
 ccttcatgtc agttggaagt gcagttatat caaaagaaaa tacaggacct ttcagataat   1020
 agggaaaaat tagccagtat cttaaaggag agcctgaact tggaggacca aattgagagt   1080
 gatgagtcag aactgaagaa attgaagact gaagaaaatt cgttcaaaag actgatgatt   1140
 gtgaagaagg aaaaacttgc cacagcacaa ttcaaaataa ataagaagca tgaagatgtt   1200
 aagcaataca aacgcacagt aattgaggat tgcaataaag ttcaagaaaa aagaggtgct   1260
 gtctatgaac gagtaaccac aattaatcac gagatccaaa agattagact tggaattcaa   1320
 caactaaaag atgctgctga tagggagaaa ctgaagtccc aggaaatatt tctaaacttg   1380
 aaaactgctt tggagaaata ccacgacggt attgaaaagg cagcagagga ctcctatgct   1440
 aagatagatg agaagacagc tgaactgaag aggaagatgt tcaaaatgtc aacctgatta   1500
 acaaaattac atgtcttttt gtaaatggct tgccatcttt taattttcta tttagaaaga   1560
 aaagttgaag cgaatggaag tatcagaagt accaaataat gttggcttca tcagttttta   1620
 tacactctca taagtagtta ataagatgaa tttaatgtag gcttttatta atttataatt   1680
 aaaataactt gtgcagctat tcatgtctct actctgcccc ttgttgtaaa tagtttgagt   1740
 aaaacaaaac tagttacctt tgaaatatat atattttttt ctgttacaaa              1790



      <210> 1868
      <211> 3670
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3670)
      <223> n = a,t,c or g


      <400> 1868
 tttcgtggag aaacccggcc cccagaagat tgtgggtgta gtggccacag ccttacaggc     60
 aggcaggggt ggttggtgtc aacagggggg ccaacagggt accagagcca agaccctcgg    120
 cctcctcccc cgccgccttc ctgcagatct gcttggcttt gaggaagagt ggcagtactg    180
 cctcactgca taagggatgg gatcagagaa cagtgcttta aagagctata cactgagaga    240
 accaccattt accttaccct ctggacttgc tgtttatccc gctgtactgc aagatggcaa    300
 atttgcttca gtttttgtgt ataagagaga aaatgaagac aaggttaata aagctgccaa    360
 ggtaccataa tagcatttga agacacttcg tcacccttgc ttgctaagat ttttatcttg    420
 tactgtggaa gcggatggca ttcatcttgt cactgagcga gtacagcccc tggaagtggc    480
 tttggaaaca ttgtcttctg cagaggtctg tgctgggatc tatgacatat tgctggctct    540
 tatcttcctt catgacagag gacacctaac acacaataat gtctgtttat catctgtgtt    600
 tgtgagtgaa gatggacact ggaagctagg aggaatggaa actgtttgta aagtttctca    660
 ggccacacca gagtttctga ggagtattca gtcaataaga gacccagcat ctatccctcc    720
 tgaagagatg tctccagaat tcacaactct cccagagtgt catggacatg cccgggatgc    780
 cttttcattt ggaacattgg tggaaagttt gctcacaatc ttaaatgaac aggtttcagc    840
 ggatgttctc tccagctttc aacagacctt gcactcaact ttgctgaatc ccattccaaa    900
 atggcggcca gcgctctgca ccttactatc tcatgacttc ttcagaaatg attttctgga    960
 agttgtgaat ttcttgaaaa gtttaacatt gaagagtgaa gaggagaaaa cggaattctt   1020
 taaatttctg ctggacagag tcagctgctt gtcagaggaa ttgatagctt caaggttggt   1080
 gcctcttctg cttaatcagt tggtgtttgc agagccagtg gctgtttaag agttttcttc   1140
 cttatctgct tggccccaaa aaagatcatg cgcagggaga aactccttgc ttgctctcac   1200
 cagccctgtt ccagtcacgg gtgatccccg tgcttctcca gttgtttgaa gttcatgaag   1260
 agcatgtgcg gatggtgctg ctgtctcaca tcgaggccta cgtgggagca ctttcactca   1320
 gggagcagct gaagaaagtt catcttggcc acaggtttta ctggggcctg cgtgatnact   1380
 agcgattcca ttgtggcaat tactctgcat agcctagcag tgctggtctc tctgcttgga   1440
 ccagaggtgg ttgtgggagg agaacgaacc aagatcttca aacgcactgc ccccaagttt   1500
 tactaaaaaa tactgacctt tctctagaag gcgatccatt ttctcagcct attaaatttc   1560
 ccataaatgg actctcagat gtaaaaaata cttcggagga cagtgaaaac ttcccatcaa   1620
 gttctaaaaa gtctgaggag tggcctgact ggagtggacc tgagggagcc tgaaaatcaa   1680
 actgtcaaca taccagattt ggccctagag aacctttgtg atgatgtcaa gtcccagtgc   1740
 actaccttgg atgtggaaga gtcatcttgg gatgactgcg agcccagcag cttagatact   1800
 aaagtaaacc caggaggtgg aatcactgct acaaaacctg ttacctcagg ggagcagaag   1860
 cctattcctg ctttgctttc actcactgaa gagtctatgc cttggaaatc aagcttaccc   1920
 caaaagatta gccttgtaca aaggggggat gacgcagacc aaatcgagcc gccaaaagtg   1980
 tcatcacaag aaaggcccct taaggttcca tcagaacttg gtttaggaga ggaattcacc   2040
 attcaagtaa aaaagaagcc agtaaaagat cctgagatgg attggtttgc tgatatgatc   2100
 ccagaaatta agccttctgc tgcttttctt atattacctg aactgaggac agaaatggtc   2160
 ccaaaaaagg atgatgtctc cccagtgatg cagttttcct caaaatttgc tgcagcagaa   2220
 attactgagg gagaggctga aggctgggaa gaagaagggg agctgaactg ggaagataat   2280
 aactggtgac aatagatgtg agttaaactt taggaaaaag gattcccttt ttttaaaaaa   2340
 aatcaatacc tcaaaagcag gctttgggac aagaaaaccc caaagtggcc tgcttttccc   2400
 atcccaggag ctcattatcc agtctgtgcc aactgaagta ggagactgac tgtgagtgct   2460
 ggctaaaagc cctgggtggt gaggctcaca gtactggttt ccagggagga agagcctttg   2520
 tgcatttgac tgaggccagt ttctatggaa gagccaagta ggcttgaggg agagggtccg   2580
 aatttacctg cctttttccc cgggacaatt ccgggaagta aagaaaatgt aattccaagc   2640
 ctggttagcc ttaattttgt gcccattctt ttctttaaca taagagtaag ctctattatg   2700
 aaatacaact tttaaaaaat tttagcctat aaattatata aatgatttta aattgctgag   2760
 gtttccttag gcagcttatt tatttgttta cagttagact atctgagtaa atggttcttt   2820
 gtggacctag gcagttcctg actgttccac atgtagtaca ttgtaccaaa gttcttaata   2880
 agaatattcc ccacaatcct gttctctaaa tgtcaaataa agattatttt cactagattc   2940
 aactttacaa aatttgtttt atatctgtta gaaaatgtac agacataagt attttcagtt   3000
 gacaaagcat caaacccagt tctgcctagt gataagtttc accctagagt atgtatgtaa   3060
 cgttttagct tatccatcct ttcttggagc gcctccattt ccattgaaag ccaggctgga   3120
 gcaggaccct tttggagtag tgactcagtt gcttccaaag cccctgtcta ttgtatgcag   3180
 cgctgaccat gtactcttct tcccaggggg aactcctgac gagctcttat tgcataaggc   3240
 tgtaaagatg acctctatgc ttcttctaca gtcacattag gcaaagggtt cccaggaaaa   3300
 tacctttttt cctgtttcac acgttccact ttgggcagct ttcagtttca tctacaaacc   3360
 cagtcttctc cagaaaggat acaactttgt tcttagtttc ttcagaactg agacactgtg   3420
 gaactatctc ttcatgattt gttccctcag cgaactgagt aaacgcctcc aaggtatgtt   3480
 gttctagcag ccaactcctg tcagctagca gtaaggcaaa catacaggac aggttgggca   3540
 gaattctgtc ctggatagct tcaggtataa aaagttttca taaagaagat acaaaatcca   3600
 acattgccta acgaacatag tcaggaagct ctaatttaag tagcgaggtc tgcaaagtta   3660
 cctcgtgccg                                                          3670



      <210> 1869
      <211> 868
      <212> DNA
      <213> Homo sapiens


      <400> 1869
 cattgcaggt gtggcagtat tcttctatcg agacatgttt gttcggaaag acagaaagat     60
 ccataaagat gcagagtccg cccagtcatg cacagactcc agtggaagtt ttgccaaact    120
 gaatggtctc tttgacagcc ctgtcaagga ataccaacag aatattgatt ctcctaaact    180
 tatagtaacc tgctaaccag tcggaaagag ctaccaccca atggagatac taaatccatg    240
 gtaatggacc atcgagggca acctccagag ttggctgctc ttcccactcc tgagtctaca    300
 cccgtgcttc accagaagac cctgcaggcc atgaagagcc actcagaaaa ggcccatggc    360
 catggagctt caaggaaaga aacccctcag ttttttccgt ctagtccgcc acctcattcc    420
 ccattaagtc atgggcatat ccccagtgcc attgttcttc caaatgctac ccatgactac    480
 aacacgtctt tctcaaactc caatgctcac aaagctgaaa agaagcttca aaacattgat    540
 caccctctca caaagtcatc cagtaagaga gatcaccggc gttctgttga ttccagaaat    600
 accctcaatg atctcctgaa gcatctgaat gacccaaata gtaaccccaa agccatcatg    660
 ggagacatcc agatggcaca ccagaactta atgctggatc ccatgggatc gatgtctgag    720
 gtcccaccta aagtccctaa ccgggaggca tcgctatact cccctccttc aactctcccc    780
 agaaatagcc caaccaagcg agtggatgtc cccaccactc ctggagtccc aatgacttct    840
 ctggaaagac aaagaggtta tcacaaaa                                       868



      <210> 1870
      <211> 908
      <212> DNA
      <213> Homo sapiens


      <400> 1870
 gggaggcggg cagcggagcc aagctgaccc ggcgagcgga gccggggctg gagagcggcg     60
 accactgcgg atctcggaag gaagaaatga tgtaaatcac tcatccaaac cttaaggtca    120
 aaggtgagaa ggaaggtcag gaagaacatg gcctggccaa atgtttttca aagagggtct    180
 ctgctgtccc agttcagcca tcatcatgtt gtagtgttcc tgctcacttt cttcagttat    240
 tcgttgctcc atgcttcacg aaaaacattt agcaatgtca aagtcagtat ctctgagcag    300
 tggaccccaa gtgcttttaa cacgtcagtt gagctgcctc tggagatctg gagcagcaac    360
 catttgttcc ccagtgcaga gaaagcgact cttttcctcg gcacactgga taccattttc    420
 ctcttctcct atgctgtggg cctattcatc agtggcatcg ttggggatcg gttgaatttg    480
 cgatgggttc tgtcttttgg catgtgctct tctgcattag tggtgtttgt ctttggtgcg    540
 ctcacagaat ggctgcgttt ttacaacaaa tggctgtact gctgcctgtg gattgtgaac    600
 ggcctgctgc agtccactgg ttggccctgt gtggttgctg ttatgggcaa ctggtttggg    660
 aaagccggac gaggagttgt ttttggtctc tggagtgcct gtgcttcggt gggcaacatt    720
 ttgggagcgt gcctagcttc ttctgttctt cagtatggtt atgagtatgc ctttctggtg    780
 acggcgtctg tgcagtttgc tggtgggatc gttatcttct ttggactcct ggtgtcacca    840
 gaagaaattg gtctctcggg tattgaggca gaagaaaact ttgaagaaga ctcacacagg    900
 ccattaat                                                             908



      <210> 1871
      <211> 413
      <212> DNA
      <213> Homo sapiens


      <400> 1871
 actttggttt caatgggtgt tccaaaagga tcatcaagct tcaggagctt tctgaccttg     60
 aagaaaggga aaatgaagat agcatggtgc cacttccgaa gcaaagcctg aagttcttct    120
 gtgctttaga agtggtgttg ccatcctgtg attgcaggag tcctggcatt ggcttggtgg    180
 aggagcctat ggataaggtg gaggaaggac cattatcatt ccttatgaaa aggaagacag    240
 cccagaagct tgctattcag aaggctttgt cagatgcatt ccagaaactg ttgattgttg    300
 ttctaggtaa gactgtcttg atcatccttg aagtacttca gtttcagtaa gcaaataaac    360
 tcattttgaa aagttaattg aataaaaata ttgatatcta aagcaaaaaa aaa           413



      <210> 1872
      <211> 432
      <212> DNA
      <213> Homo sapiens


      <400> 1872
 caagaatcgg tcaaggtgtt cctgtggtgc actcataagt ggaaggagga cccaatgtga     60
 tctcgattgt tttggagtac cttcgagaca cccctcccgt gccagtggtt gtctgtgatg    120
 ggagtggacg ggcatcggac atcctggcct ttgggcataa atactcagaa gaaggcgggt    180
 aggtaacttt ccaggcccca tggaagaacc ctaaagcctg tttggaaacg agggtatgag    240
 tggattatgt tttcagtagc tcaaccaaga cctcaaatca aaacaagcta tggaacaaat    300
 tgtctaaaaa atgtctgtca tgggagggct gtggtgaaga acagagaaac atattctaaa    360
 tgtcctgtga agtgggaaat tctatgaaag ctacacggat aataaaaagg gtgaggaaaa    420
 gagaggaaaa aa                                                        432



      <210> 1873
      <211> 643
      <212> DNA
      <213> Homo sapiens


      <400> 1873
 aatacatacc ctgtgtatcc tggactgcaa tgacattggc ctgtggcagc atcacacgtc     60
 cctccattat ggcactggca ttcttgggaa cagttctttc caaagcgacc ctcggggcaa    120
 ggctgaccac acactgtgcc catccagcca gaagggcaag agcattctcc agtgacgtga    180
 tgacacactc ctccattttg acaagggcat ctctgctcac actgtggacc atgtttacca    240
 ggaggacaaa gatcctcaca gaaggctccg gtgtatcctg gtgggcagcg gcattccccc    300
 gtgacgtggt cgcaggtggc tccattctgg cactggcatc tctgatgaca gtcgttacca    360
 taggtgccct gctcacagcg gtcctcgcag cgccagcccc ggaagcccgc agcacagtgg    420
 caagccccgg tgatggggtt gcacagagcc ccatttttgc actggcaccg gctggtgcag    480
 tggggacccc agtgatcacc atcgcaggct gagattgagg agagaaacag tggatatcag    540
 tgggtaaggg agaaccagat ttcttcgcct ctcggggaga atggcttggt gacctctcat    600
 ggccattcat tagctggaca tcagggccct ggccccaacc cat                      643



      <210> 1874
      <211> 2193
      <212> DNA
      <213> Homo sapiens


      <400> 1874
 tttttttttt ttaactggca aaggcatatt tttatttaaa taaatcaatc tcacaactgt     60
 aattcgaact tgaaattagc aaagtttctt tcacttctta cacataaaaa ccttaaattt    120
 taactgtaat aaagtgtgaa tcctttaata acctgggttt ttaaaagggt gccacccaat    180
 gggggtaatg gaaaaggggg atgttaatgt actaggcttc cctggaaaat attttaaaca    240
 tttttcatac aatactaggg aaaacttccc cttcttccac gtttaggctt aatagaacaa    300
 atcacatgga aagtttcata gtgggttctt ttatttataa aataatcaca ttcaagtctt    360
 accagagagt agcaaagtct tcaattcctt tcctttcctt tgaagaaata atgtagagca    420
 atcactcata aatccctcta attataaata aaatccaaga tattatttga caatgagatg    480
 ctttatttaa acttgataca tttactatat aagaattctg tgaaaaaatg gggtatgaaa    540
 ttattttgga tctgaatctt tgcattataa aatctaaccc aaaactatgt catttcactg    600
 tattctgtga ctattagcag atggatgacc aaaggcaact acttcctttc ctggcaaaac    660
 aagacaagtt tcagctgact tccccatggt gttacaagtt ctcctagtga agtaaaaagt    720
 cccaacccct ctttctatgc atgtcatctc caggaaggta agctttggga agcacctgcg    780
 ccagccctat atctgtgctt ggcatgaggt tcacacaggt tcggccttga gatggggatg    840
 ttcctctcaa ccaaacaact ctacttgaat tattccgaga ctccttggag gggtgaaact    900
 tcaggcctgg gtgtctctgc agtgagatgt ctgtggttgg taaacagttc tgtagagtct    960
 tgttctactg atctttcttc taggtctgac tctgggattg tagtacaacc acctggcatg   1020
 accatggtct ggtgggggct gctgcatcgg tacttaggca gagacggcca cctttggata   1080
 atctatcgca gagcaaggtg atatgtttct tcagttgggc tcgtgtcatt ggggtatgtc   1140
 agcctgcctg gtgggttcaa agcctgctgc ttagcactct tacgacagca agtctttcac   1200
 atggtggaaa atggcggcat ccaccgtttc ttcccagccc aattcttgag tgtcttcttg   1260
 tagcggcaga aatgccgctt ccagaatagc aacctggtca gcactaagct tctgccacag   1320
 cgcgatcagc agaatcacca aatgggtggc actcttcagc ctggtgaatg actggaacag   1380
 attgcccttg gttttccctc ccactgcatc ctgctagagc aattacctgc cttgtaggtt   1440
 cccatcctaa caaggtgtcc caggtgttga agaggggcag gagttttatc tttgaatctt   1500
 gctagtagcc ggcgttgaat ggcccgaaat tgtacagctc tctcagataa gagttcttct   1560
 aatttttcac catttatccg tagctcaaaa tggatggatc caatcaactc caaaatattc   1620
 cttgaaaggg gtaatagatc cccgaaaaag aacatgcaaa atctttgact ccctgttttt   1680
 caaaatattc ttgaaggcga agaataagct cattggttaa tgaagcccaa agatccttca   1740
 aattgttcca ctcctggaat gcgaatatcc gttgaagaag ttttggaagc aagaacagta   1800
 attccgagca cctccctaag aagtgaaaac ccattacatt cacctgatca tcatctgact   1860
 gactggcaaa acctgggaag agactaagaa gactgactgg agatttgttg gtatcaatag   1920
 taattttgtg gcttgcagtt tttgaaggct gacctggtag gcaaattaac tttaggggaa   1980
 gtctaaattt acattggata actcgcggaa tgccatcagg atttcgattc ataaattcaa   2040
 aggtgaactg atcacaagtc aattctaatg gtggttgcac gtagactgat aatttggctt   2100
 tttgcaatat cactctgttc tgcagtgtga ccttcaccgt gacagaaggg acaaggtcag   2160
 ttcccacctc aacatcggtc gcttgagaaa ctg                                2193



      <210> 1875
      <211> 473
      <212> DNA
      <213> Homo sapiens


      <400> 1875
 gaagtgcgct ggaattcccc tccaacggat tccctctccc ccgacggcgg cagcatcgag     60
 ctggagttct acctggcgcc cgagccgttc tccatgccca gcctgttggg agctccaccc    120
 tactctggcc tgggcggtgt aggggatccc tatgcgcccc tcatggtgct gatgtgccgg    180
 gtgtgcctgg aagacaagcc catcaagccc ctgccttgct gcaagaaggc cgtgtgcgag    240
 gagtgcctca aagtctacct gagcgcccag atccagtgcc ctacctgcca attcgtctgg    300
 tgttttaagt gccactctcc ttggcatgaa ggtgttaact gcaaggagta caaaaaagga    360
 gacaaattgt tgcgtcactg ggccagcgaa attgagcatg ggcagaggaa tgcccagaag    420
 tgtccaaagt gcaagatcca catccagcga actgaaggat gtgaccatat gac           473



      <210> 1876
      <211> 1098
      <212> DNA
      <213> Homo sapiens


      <400> 1876
 gaagcggctg gcgggcagca gaggaggatg gcgaggggct gatactgaac ccgggaaggg     60
 tgggctgtgc tgaagccaga gccggagccg gagctggggc cagaacccga gcagtgagtt    120
 cctccactga cgagttccgg ctggcggcgc tcgccgcctt gggcaggacc cacctcgcct    180
 tcctcccggc gtggcagatg ctccagctgc catgtccacg cagagacttc ggaatgaaga    240
 ctaccacgac tacagctcca cggacgtgag ccctgaggag agcccgtcgg aaggcctcaa    300
 caacctctcc tccccgggct cctaccagcg ctttggtcaa agcaatagca caacatggtt    360
 ccagaccttg atccacctgt taaaaggcaa cattggcaca ggactcctgg gactccctct    420
 ggcggtgaaa aatgcaggca tcgtgatggg tcccatcagc ctgctgatca taggcatcgt    480
 ggccgtgcac tgcatgggta tcctggtgaa atgtgctcac cacttctgcc gcaggctgaa    540
 taaatccttt gtggattatg gtgatactgt gatgtatgga ctagaatcca gcccctgctc    600
 ctggctccgg aaccacgcac actggggaag acgtgttgtg gacttcttcc tgattgtcac    660
 ccagctggga ttctgctgtg tctattttgt gtttctggct gacaacttta aacaggtgat    720
 agaagcggcc aatgggacca ccaataactg ccacaacaat gagacggtga ttctgacgcc    780
 taccatggac tcgcgactct acatgctctc cttcctgccc ttcctggtgc tgctggtttt    840
 catcaggaac ctccgagccc tgtccatctt ctccctgttg gccaacatca ccatgctggt    900
 cagcttggtc atgatctacc agttcattgt tcagatcctg tgaatggatt tacagcccat    960
 gtagcagacc aaggtcttcc acagagagca ggttcctctc tgtcttcagc atgtggagtc   1020
 tcaaatggaa cagttctggg cagagtgctt tgcacagagg gtgctcccaa taaatgtttt   1080
 atcactgcaa aaaaaaaa                                                 1098



      <210> 1877
      <211> 1098
      <212> DNA
      <213> Homo sapiens


      <400> 1877
 gaagcggctg gcgggcagca gaggaggatg gcgaggggct gatactgaac ccgggaaggg     60
 tgggctgtgc tgaagccaga gccggagccg gagctggggc cagaacccga gcagtgagtt    120
 cctccactga cgagttccgg ctggcggcgc tcgccgcctt gggcaggacc cacctcgcct    180
 tcctcccggc gtggcagatg ctccagctgc catgtccacg cagagacttc ggaatgaaga    240
 ctaccacgac tacagctcca cggacgtgag ccctgaggag agcccgtcgg aaggcctcaa    300
 caacctctcc tccccgggct cctaccagcg ctttggtcaa agcaatagca caacatggtt    360
 ccagaccttg atccacctgt taaaaggcaa cattggcaca ggactcctgg gactccctct    420
 ggcggtgaaa aatgcaggca tcgtgatggg tcccatcagc ctgctgatca taggcatcgt    480
 ggccgtgcac tgcatgggta tcctggtgaa atgtgctcac cacttctgcc gcaggctgaa    540
 taaatccttt gtggattatg gtgatactgt gatgtatgga ctagaatcca gcccctgctc    600
 ctggctccgg aaccacgcac actggggaag acgtgttgtg gacttcttcc tgattgtcac    660
 ccagctggga ttctgctgtg tctattttgt gtttctggct gacaacttta aacaggtgat    720
 agaagcggcc aatgggacca ccaataactg ccacaacaat gagacggtga ttctgacgcc    780
 taccatggac tcgcgactct acatgctctc cttcctgccc ttcctggtgc tgctggtttt    840
 catcaggaac ctccgagccc tgtccatctt ctccctgttg gccaacatca ccatgctggt    900
 cagcttggtc atgatctacc agttcattgt tcagatcctg tgaatggatt tacagcccat    960
 gtagcagacc aaggtcttcc acagagagca ggttcctctc tgtcttcagc atgtggagtc   1020
 tcaaatggaa cagttctggg cagagtgctt tgcacagagg gtgctcccaa taaatgtttt   1080
 atcactgcaa aaaaaaaa                                                 1098



      <210> 1878
      <211> 1775
      <212> DNA
      <213> Homo sapiens


      <400> 1878
 ggtggttcag ggggcgtgta acctgggccg attctgcccc agcacactgg ttgtcgggag     60
 ccccgcctcc gctcgcggtt gacagctcag ctggtgccga gcaactcgtg ccagccagtc    120
 gtgtctcagc ctggagagtg cgcgcaccgc cgcccgggca gccgctggct ccagctcacg    180
 aaacagcccc gggcgccgcg ccgctctgag tccagcctcc tactgagaac agtccctccc    240
 ttgtgcgggt cgcacggcta gccgcaggtt cggccacgtc aaatccattt tctaaaaaag    300
 cagggagcag agctctctct tcgccgccga cgcagaaagg agctggggag gaaaaagctg    360
 ctgccttttg cgctggagat tcgtgggcaa ggcttctcat tttcccaggc tgcttcccct    420
 cccgggtgag gagcgtcctg agactaagga aagagcctgg aaaatggagc agacctggac    480
 gagagattat tttgcagagg atgatgggga gatggtaccc agaacgagtc acacagcagt    540
 tctgtttcat tgacagcttt tcttagtgac actaaagatc gaggccctcc agtgcagtca    600
 cagatctgga gaagtggtga aaaggtcccg tttgtgcaga catattcctt gagagcattt    660
 gagaaacccc ctcaggtaca gacccaggct cttcgagact ttgagaagca cctcaatgac    720
 ctgaagaagg agaacttcag cctcaagctg ctcatctact tcctggagga gcgcatgcaa    780
 cagaagtatg aggccagccg ggaggacatc tacaagcgga acactgagct gaaggttgaa    840
 gtggagagct tgaaacgaga actccaggac aagaaacagc atctggataa aacatgggct    900
 gatgtggaga atctcaacag tcagaatgaa gctgagctcc gacgccagtt tgaggagcga    960
 cagcaggaga tggagcatgt ttatgagctc ttggagaata agatgcagct tctgcaggag   1020
 gaatccaggc tagcaaagaa tgaagctgcg cggatggcag ctctggtgga agcagagaag   1080
 gagtgtaacc tggagctctc agagaaactg aagggagtca ccaaaaactg ggaagatgta   1140
 ccaggagacc aggtcaagcc cgaccaatac actgaggccc tggcccagag ggacaagtag   1200
 gtgccttcgg tgctcttttt gtcgcttgtc ttttgcccat tctcaaggca tacagcagct   1260
 gtcctgttcc ctttcaagga ctgacagtag gagcttcact atttctaaga ctttatgggc   1320
 ccacaaccga agacattctt ttcagggttg aattttcagt ggtatccatt atgaaaactc   1380
 acttcatgga ttcagtgggc aaatagcggc aagcaagaga catggattca cttattcggc   1440
 aaacatttac tgggcatgcc acatgccaga taccgggcta agtatctggc atgtgttaca   1500
 gaaacaaaag acctaaatct tgtcaccaag aaacatgtta catgatttta ataagttccc   1560
 tgatagaaga gcatggggtg ctctggggaa atattggagg gtcatccatt ccacattaaa   1620
 agagcaagtt gtctgctgtg gtctgaatgt ttgtgtccca tccccacctc cctcccccac   1680
 cagtttatat gttgaaatct taacccttaa ggttaatact tctgcctcca gaagtattat   1740
 gaggtggagc cattaggagg tgattaaatc ataga                              1775



      <210> 1879
      <211> 457
      <212> DNA
      <213> Homo sapiens


      <400> 1879
 cagaggccat ctgaagccaa agagataaaa ctttatgccc agattccccc tatagagaag     60
 atggatgcat ccttgtccat gcttgctaat tgcgagaagc tttcactgtc tacaaactgc    120
 attgaaaaaa ttgccaacct gaatggctta agaggcagta ggggacacat tagaagaact    180
 gtggatctcc tacaatttta ttgagaagtt gaaagggatc cacataatga agaaattgaa    240
 gattctctac atgtctaata acctggtaaa agactggggt actccagtaa ttaaagggga    300
 tgaggaagaa gacaactaat gccacgcttt ccactgtgtg ttaacttatt taaatgtcat    360
 aagaacaata gataaatttt atataattgt ctattttaaa gattctgtat gggccaaaag    420
 tttcttaaga taaaacagat cactcattct caaaaaa                             457



      <210> 1880
      <211> 880
      <212> DNA
      <213> Homo sapiens


      <400> 1880
 atgcaagaac actcttatca gacagaacat cccaagagct cagttcccag caaccagccc     60
 aaggtccata attcagcagc caaatctttc cctcgaaggt ttgttttgcc tttaaatgtc    120
 agtttgaatg cccctgaggg agacaacctg agtccattgt cctatacttc agccagtgct    180
 gtgaaacagg ctgatggaac gatctggtgc tctcatgaaa atctacatca ggaggaccta    240
 gaaaaggaag gaggcattga atttcctcag atctactatg atcgattcag tggcaaaaag    300
 tatcatttct tttatggctg tggctttcgg catttagtgg gggattctct gatcaaggtt    360
 gatgtggtga ataagacact gaaggtttgg agagaagatg gcttttatcc ctcagaacct    420
 gtttttgttc cagcaccagg aaccaatgaa gaagatggtg gggttattct ttctgtggtg    480
 atcactccca accagaatga aagcaatttt ctcctagttt tggatgccaa gaactttgaa    540
 gagctgggcc gagcagaggt acctgtgcag atgccttatg ggttccatgg taccttcata    600
 cccatctgat gggacaacca caaggtctgg aaactaggtt taaaataagt gtgcacttgg    660
 acataaagac tggagaaata aacactgagg actccaaaag gggggcaagg aggaagaggg    720
 gcaggggtta aaaagctacc tattgaatac tatgttccct atttgggtga tgggttcgtt    780
 agaagtccaa acctcagcag cacacaatat actcatgtaa caagcctgca catgtacccc    840
 agaatctaaa ataaaaataa aaagaaaaac aaaaaaaaaa                          880



      <210> 1881
      <211> 880
      <212> DNA
      <213> Homo sapiens


      <400> 1881
 atgcaagaac actcttatca gacagaacat cccaagagct cagttcccag caaccagccc     60
 aaggtccata attcagcagc caaatctttc cctcgaaggt ttgttttgcc tttaaatgtc    120
 agtttgaatg cccctgaggg agacaacctg agtccattgt cctatacttc agccagtgct    180
 gtgaaacagg ctgatggaac gatctggtgc tctcatgaaa atctacatca ggaggaccta    240
 gaaaaggaag gaggcattga atttcctcag atctactatg atcgattcag tggcaaaaag    300
 tatcatttct tttatggctg tggctttcgg catttagtgg gggattctct gatcaaggtt    360
 gatgtggtga ataagacact gaaggtttgg agagaagatg gcttttatcc ctcagaacct    420
 gtttttgttc cagcaccagg aaccaatgaa gaagatggtg gggttattct ttctgtggtg    480
 atcactccca accagaatga aagcaatttt ctcctagttt tggatgccaa gaactttgaa    540
 gagctgggcc gagcagaggt acctgtgcag atgccttatg ggttccatgg taccttcata    600
 cccatctgat gggacaacca caaggtctgg aaactaggtt taaaataagt gtgcacttgg    660
 acataaagac tggagaaata aacactgagg actccaaaag gggggcaagg aggaagaggg    720
 gcaggggtta aaaagctacc tattgaatac tatgttccct atttgggtga tgggttcgtt    780
 agaagtccaa acctcagcag cacacaatat actcatgtaa caagcctgca catgtacccc    840
 agaatctaaa ataaaaataa aaagaaaaac aaaaaaaaaa                          880



      <210> 1882
      <211> 580
      <212> DNA
      <213> Homo sapiens


      <400> 1882
 ggtgaaaaat gatgattgtg gcttccttgc taactgggtt agagaagtga tcaagtgtga     60
 accgggactt gaatgagagg agtgacttag catttggtga ctgtccttaa cgaagaactg    120
 tgcgctcctg ggcgaagaaa caatgatgga gcaggaaatg acccggttac atcggagagt    180
 gtcagaggtg gaggctgtgc ttagtcagaa ggaggtggag ctgaaggcct ctgagactca    240
 gagatccccc ctggagcagg accttgctac ctacatcaca gaatgcagta gcttaaagcg    300
 aagtttggag caagcacgaa tggaggtgtc ccaggaggat gacaaagcac tgcagcttct    360
 ccatgatatc agagagcaga gccggaagct ccaagaaatc aaagagcagg agtaccaggc    420
 tcaagtggaa gaaatgaggt tgatgatgaa tcagttggaa gaggatcttg tctcagcaag    480
 aagacggagt gatctctacg aatctgagct gagagagtct cggcttgctg ctgaagaatt    540
 caagcggaaa gcgacagaat gtcagcataa actgttgaag                          580



      <210> 1883
      <211> 2028
      <212> DNA
      <213> Homo sapiens


      <400> 1883
 atggcctggg caggacgggg ccggggcagc cgtcagggtt ccgagctgca tcttccctgg     60
 gccatagatg tctgcttatt tagtttggtc cgttcagggt tccgtttcct aagggaggtt    120
 tggtgggaga tctggaagaa agtgctgctg cttctgcatg tagcaaatgg tgcccagcag    180
 gcagggccca tcccctggaa cacagggcta caagccaacc actctgtgcc tgtgagtaaa    240
 ccacaccaaa aatggccagt ccagcacttc caggagctgc tcaggtcagc aaactctttg    300
 acagctcctt tcaaacaggt acagtactgg agggggacaa agatgaacca gagggtccct    360
 gtgccccaaa ttcacagctg gttccgaatg ttctgtggca tggctcatga gagccacggc    420
 atagggaagt ggggtgtggc tttggaggga caccctcctg gcccaggaaa acaggaaagc    480
 atagccaatg cctgctggga ggcagcagtt agaagtccag gctctagatc tcacaaagca    540
 gagaccaaat cttcaaaaag cagagaccaa atcctgtctg tcctgcgacc tgccagcttt    600
 gtcagggaca agagcattcc acagccctgg ctggagagtg atgggattaa caagagatgg    660
 agccccacat gcctctcagg ggaaccctcg cttggtcgag tgaaccctct gctacatgag    720
 cttcagactc agtgctttgt aagaacacca agttatcaga gggctacaga ggcagcaaag    780
 cctcaagaga gatgcacaat ccaactgaat aagatgtgtt gtctgcaagc agggtcattc    840
 tcaaggtatg cttcagttat tgctatcaag cacatctgcc atgcacattc cacccccaaa    900
 gcccttctga cttcattctt ggttcttact actactcgaa gtctgaactt acacttacac    960
 cttcgccttt cacatccaga caaattcaga gatggaggag tatcatcttc acagtactcc   1020
 cgctactgct ccttaactca gccagacttt gactctagca attcctctac tttcttcctc   1080
 ctattaacca tatcccttct aagtagccaa ttctgtatca ggcttatatc cctgcctgag   1140
 tgtcccgtca gtcaatggca ggaagcagcc cgtgaacatc ttggaggggg cagtgatttg   1200
 tcctcaatgg gggagacaca tccagatttg ggtgggggcc ccagtgaggg ccctggtggc   1260
 tggccgtggg agcaagtcag tgcagcattt gctcagcttg tgcttgtgag caccatgtcc   1320
 ttccaaggca cttggcgaaa gagattctcc tccacagaca cacagatcct gcctttcacc   1380
 tgtgcctatg gcctcgtcct tcaggtcccc atgatgcacc aaacgaccga ggtcaactac   1440
 ggtcagttcc aggacactgc aggccatcag gtgggggtgc tggagcttcc ttacctggga   1500
 agtgcagtga gtctgttcct ggtgctgccc cgtgacaaag acacccccct gagccacatc   1560
 gagccacacc tcacagccag caccatccac ctctggacca ccagcctgag gagagccagg   1620
 atggatgtgt tcctgcccag tgaattgacc aaggaacctt ttcgttggga tcagagactc   1680
 tttgcattag tgttgcggtt gcctggcacc atgtcagtag aatcagaaca gttgacaggt   1740
 gtgcctttag atgactctgc aatcacacca atgtgtgaag tgacaggcgt gggtatggag   1800
 tgctttagtg atgctaaaga caccattgaa gacctttcag aaatgcatgg gagtcaagac   1860
 ctctcagaaa tgcgggggaa ccccaccaag ccttcacccc cactctctgg gaccacagtg   1920
 gagaattttg gcagcagagg gacagacagc tatgaggcct tctctgagcc ttctttgggc   1980
 aaagagcctg tcacacacag gaccagggtt ccactccagt ggccctga                2028



      <210> 1884
      <211> 2082
      <212> DNA
      <213> Homo sapiens


      <400> 1884
 cccgggtcga cccacgcgtc cggggagcaa cctcagcttc tagtatccag actccagcgc     60
 cgccccgggc gcggacccca accccgaccc agagcttctc cagcggcggc gcagcgagca    120
 gggctccccg ccttaacttc ctccgcgggg cccagccacc ttcgggagtc cgggttgccc    180
 acctgcaaac tctccgcctt ctgcacctgc cacccctgag ccagcgcggg cgcccgagcg    240
 agtcatggcc aacgcggggc tgcagctgtt gggcttcatt ctcgccttcc tgggatggat    300
 cggcgccatc gtcagcactg ccctgcccca gtggaggatt tactcctatg ccggcgacaa    360
 catcgtgacc gcccaggcca tgtacgaggg gctgtggatg tcctgcgtgt cgcagagcac    420
 cgggcagatc cagtgcaaag tctttgactc cttgctgaat ctgagcagca cattgcaagc    480
 aacccttgcc ttgatggtgg ttggcatcct cctgggagtg atagcaatct ttgtggccac    540
 cgttggcatg aagtgtatga agtgcttgga agacgatgag gtgcagaaga tgaggatggc    600
 tgtcattggg ggcgcgatat ttcttcttgc aggtctggct attttagttg ccacagcatg    660
 gtatggcaat agaatcgttc aagaattcta tgaccctatg accccagtca atgccaggta    720
 cgaatttggt caggctctct tcactggctg ggctgctgct tctctctgcc ttctgggagg    780
 tgccctactt tgctgttcct gtccccgaaa aacaacctct tacccaacac caaggcccta    840
 tccaaaaacc tgcaccttcc cagcgggaaa gactacgtgt gacacagagg caaaaggaga    900
 aaatcatgtt gaaacaaacc gaaaatggac attgagatac tatcattaac attaggacct    960
 tagaattttt gggtattgta atctgaagta tggtattaca aaacaaacaa acaaacaaaa   1020
 aacccatgtg ttaaaatact cagtgctaaa catggcttaa tcttatttta tcttctttcc   1080
 tcaatatagg aggggaagat ttttcccatt tgtattactg cttcccattg agtaatcata   1140
 ctcaactggg ggaaggggtg ctccttaaat atatatagat atgtatatat acatgttttt   1200
 ctattaaaaa tagacagtaa aatactattc tcattatgtt gatactagca tacttaaaat   1260
 atctctaaaa taggtaaatg tatttaattc catattgatg aagatgttta ttggtatatt   1320
 ttctttttcg tctatatata catatgtaac agtcaaatat catttactct tcttcattag   1380
 ctttgggtgc ctttgccaca agacctagcc taatttacca aggatgaatt ctttcaattc   1440
 ttcatgcgtg cccttttcat atacttattt tattttttac cataatctta tagcacttgc   1500
 atcgttatta agcccttatt tgttttgtgt ttcattggtc tctatctcct gaatctaaca   1560
 catttcatag cctacatttt agtttctaaa gccaagaaga atttattaca aatcagaact   1620
 ttggaggcaa atctttctgc atgaccaaag tgataaattc ctgttgacct tcccacacaa   1680
 tccctgtact ctgacccata gcactcttgt ttgctttgaa aatatttgtc caattgagta   1740
 gctgcatgct gttcccccag gtgttgtaac acaactttat tgattgaatt tttaagctac   1800
 ttattcatag ttttatatcc ccctaaacta cctttttgtt ccccattcct taattgtatt   1860
 gttttcccaa gtgtaattat catgcgtttt atttcttcct aataaggtgt ggtctgtttg   1920
 tctgaacaaa gtgctagact ttctggagtg ataatctggt gacaaatatt ctctctgtag   1980
 ctgtaagcaa gtcacttaat ctttctacct ctttttttgc tatctgccaa attgagataa   2040
 tgatacttaa ccagttagaa gaggtagtgt gaatatttaa tt                      2082



      <210> 1885
      <211> 1282
      <212> DNA
      <213> Homo sapiens


      <400> 1885
 aggggcagcg acgcggaaga tgactcaggg cccactttga acctcctggg tacttgagca     60
 agctcaaggg tgttcggacc tctagggaga cgttgcatca cgcagtttgg aaagaacttg    120
 ggaattctcc ctggggggct cgctgtattt actgggaact agtcttgcag gaaggcttat    180
 gtacagaagt acgtcgtgaa gaattatttc tactattacc tatcaatttt cagctgcttt    240
 gggccaagaa gtgttctaca tcacgtttct tccattcact cactggaata ttgaccctta    300
 tttatccaga agattgatca tcatatgggt tttggtgatg tatattggcc aagtggccaa    360
 ggatgtcttg aagtggcccc gtccctcctc ccctccagtt gtaaaactgg aaaagagact    420
 gatcgctgaa tatggaatgc catccaccca cgccatggcg gccactgcca ttgccttcac    480
 cctccttatc tctactatgg acagatacca gtatccattt gtgttgggac tggtgatggc    540
 cgtggtgttt tccaccttgg tgtgtctcag caggctctac actgggatgc atacggtcct    600
 ggatgtgctg ggtggcgtcc tgatcaccgc actcctcatc gtcctcacct accctgcctg    660
 gaccttcatc gactgcctgg actcggccag ccccctcttc cccgtgtgtg tcatagttgt    720
 gccattcttc ctgtgttaca attaccctgt ttctgattac tacagcccaa cccgggcgga    780
 caccaccacc attctggctg ccggggctgg agtgaccata ggattctgga tcaaccattt    840
 cttccagctt gtatccaagc ccgctgaatc tctccctgtt attcagaaca tcccaccgct    900
 caccacctac atgttagttt tgggtctgac caaatttgca gtgggaattg tgttgatcct    960
 cttggttcgt cagcttgtac aaaatctctc actgcaagta ttatactcat ggttcaaggt   1020
 ggtcaccagg aacaaggagg ccaggcggag actggagatt gaagtgcctt acaagtttgt   1080
 tacctacaca tctgttggca tcggcacaaa ggttgtagcg cagatgccaa cagatgtgta   1140
 ggtaaccttt gtgccgatgc ttcacaggtt tctgggatta ccctgagtct caaacagttg   1200
 gaaactagcc cactggacat gaaagccaag acataggaaa gttattggta ggcaaatctt   1260
 gacaacttat ttttctttaa ca                                            1282



      <210> 1886
      <211> 474
      <212> DNA
      <213> Homo sapiens


      <400> 1886
 atgcaaagcc ttctggaaat ccacaagctg aagatgcttg cacaatggag aacaattgaa     60
 ggagtgagtc tgggcagtga gcagattgga ggctatttca ttattagcaa tgtgctggaa    120
 gagaactcta gaacagaagt tgataaaaat tcaggagctt ttattgaatt aaagccacat    180
 ttgcctgaag aagtcagcaa agtcactgac tggaacatgg atgaagctgg aaaccatcat    240
 tctcagcaaa ctaacacagg aacagaaaac caaacactgc atgttctcac tgataagtgg    300
 gagttgaaca atgagaacac atggacacag ggaggggaac atcacacact ggggcctgtc    360
 gggggtggga ggcctagcaa ttcattagaa ttacctgtga agcttttaaa atgtaaggtt    420
 tggatggaat gctcagaccc taccttagac ccaattaagc ccacagcttt gagg          474



      <210> 1887
      <211> 474
      <212> DNA
      <213> Homo sapiens


      <400> 1887
 atgcaaagcc ttctggaaat ccacaagctg aagatgcttg cacaatggag aacaattgaa     60
 ggagtgagtc tgggcagtga gcagattgga ggctatttca ttattagcaa tgtgctggaa    120
 gagaactcta gaacagaagt tgataaaaat tcaggagctt ttattgaatt aaagccacat    180
 ttgcctgaag aagtcagcaa agtcactgac tggaacatgg atgaagctgg aaaccatcat    240
 tctcagcaaa ctaacacagg aacagaaaac caaacactgc atgttctcac tgataagtgg    300
 gagttgaaca atgagaacac atggacacag ggaggggaac atcacacact ggggcctgtc    360
 gggggtggga ggcctagcaa ttcattagaa ttacctgtga agcttttaaa atgtaaggtt    420
 tggatggaat gctcagaccc taccttagac ccaattaagc ccacagcttt gagg          474



      <210> 1888
      <211> 241
      <212> DNA
      <213> Homo sapiens


      <400> 1888
 gtactgatcg ccgcaccgga gcccgaggac gctcaccgtg ccgcctcccc gcgggagccc     60
 cgggagcggc ccatcacctc tgcagcctcg ccaggagaag aaaagttccc acgtctctac    120
 caggagaagc ccgaagctcc tgcgggagaa gcctgaagct gctgctggag aagcggcagc    180
 tgaggcagga ctcccgatgt ttgcccgcag ccgcgcgcgc agtcggtgcg ccccgacgaa    240
 a                                                                    241



      <210> 1889
      <211> 1256
      <212> DNA
      <213> Homo sapiens


      <400> 1889
 ctcgatcacc tgatggccct gcggcgcagc tcccgggttg acccacgcgt ccgagcggat     60
 gttcactctc acgaccatga ttcaagctct tgcacctgtt atgggatggg acaggaagcc    120
 actgaagatg ttttcatcag aagagatgag aggacatctt catcatcatc ataaatgtct    180
 gacgaagatc ctgaaggttg aggggcaggt tccagatctg ccatcctgcc tgcccctgac    240
 tgacaacacc cgcatgctgg cctctatcct catcaacatg ctctatgatg acctgcgctg    300
 tgacccggag cgcgatcact tccgcaagat ctgtgaggaa tatatcacgg gcaagtttga    360
 cccccaggac atggacaaga acttgaatgc catccagaca gtgtcaggga tcctgcaggg    420
 cccctttgac ctgggcaacc agctgctggg actgaaaggt gtgatggaga tgatggtggc    480
 actatgtggc tcagagcgcg agacggacca gctggtggcc gtggaggccc tcatccatgc    540
 ctccacgaag ctcagccgcg ccaccttcat catcaccaat ggagtgtcac tgctcaaaca    600
 gatctacaag accaccaaaa atgagaagat caagatccgc acactggtgg gactctgtaa    660
 gctcggctct gcaggtggca cagactacgg tctcaggcag tttgcggaag ggtcgacaga    720
 aaaactggcc aaacagtgtc gcaagtggct gtgcaatatg tccatagaca ctcggacccg    780
 acgctgggca gtggagggcc tggcctacct cacgctggac gctgatgtga aggacgactt    840
 tgtccaggac gtccctgccc tgcaggccat gtttgagctg gccaagacca gtgacaagac    900
 catcctgtac tcggtggcca ccaccctggt gaactgcacc aacagctacg atgtcaagga    960
 ggtcatccca gagcttgtcc agctcgccaa gttctccaag cagcatgtgc ccgaggaaca   1020
 ccccaaggac aagaaggact ttatagacat gcgggtgaag cggcttctga aggcgggtgt   1080
 catctctgcc ctggcttgca tggtgaaagc agatagtgcc atcctcactg accagaccaa   1140
 ggagctgctg gccagggtat tcctggcact gtgtgacaac ccaaaggacc gaggcaccat   1200
 tgtggctcaa ggtggtggca aggccctgat tcccctggct ttggagggca cagatg       1256



      <210> 1890
      <211> 3482
      <212> DNA
      <213> Homo sapiens


      <400> 1890
 atggtggaaa aggaaaagga tgccttagaa ggagagaaaa acatagctat cgaatttctt     60
 accttggaaa atgaaatatt tagaaaaaag aatcatgttt gtcaatatta tatttatgag    120
 ttgcagaaac gaattgctga aatggaaact caaaaggaaa atattcatga agataccaaa    180
 gaaattaatg agaagagcac tatacttatc aaatgaaatg aaagctaaga ataaagatgt    240
 aaaagataca gaaaagaaac tgaataaaat tacaaaattt attgaggaga ataaagaaaa    300
 atttacacag ctagatttgg aagatgttca agtttagaga aaagttaaaa catgccacga    360
 gtaaagccaa aaaactggag aaacaacttc aaaaagataa agaaaaggtt gaagaattta    420
 aaagtatgac ctgccaagag taacaatatc attaatgaaa caacaaccag aaacaatgcc    480
 ctcgagaagg aaaaagagaa agaagaacaa aaattaaagg aagttatgga tagccttaaa    540
 caggaaacac aagggcttca gaaagaaaaa gaaagtcgag agaaagaact tatgggtttc    600
 agcaaatcgg taaatgaagc acgttcaaag atggatgtag cccagtcaga acttgatatc    660
 tatctcagtc gtcataatac tgcagtgtct caattaacta aggctaagga agctctaatt    720
 gcagcttctg agactctcaa agaaaggaaa gctgcaatca gagatataga aggaaaactc    780
 cctcaaactg aacaagaatt aaaggagaaa gaaaaagaac ttcaaaaact tacacaagaa    840
 gaaacaaact ttaaaagttt ggttcatgat ctcttttcaa aaagttgaag aagcaaagag    900
 ctcattagca atgaatcgaa gtagggggaa agtccttgat gcaataattc aagaaaaaaa    960
 atctggcagg attccaggaa tatatggaag attgggggac ttaggagcca ttgatgaaaa   1020
 atacgacgtg gctatatcat cctgttgtca tgcactggac tacattgttg gttgatctat   1080
 ttgatatagc ccaagaaatg tgtaaacttc cttaaaagac aaaaatattg gagttgcaac   1140
 ttttataggt ttagataaga tggctgtatg ggcgaaaaag atgaccgaaa ttcaaactcc   1200
 tgaaaatact cctcgtttat ttgatttagt aaaagtaaaa gatgagaaaa ttcgccaagc   1260
 tttttatttt gctttacgag ataccttagt agctgacaac ttggatcaag ccacaagagt   1320
 agcatatcaa aaagatagaa gatggagagt ggtaacttta cagggacaaa tcatagaaca   1380
 gtcaggtaca atgactggtg gtggaagcaa agtaatgaaa ggaagaatgg gttcctcact   1440
 tgttattgaa atctctgaag aagaggtaaa caaaatggaa tcacagttgc aaaacgactc   1500
 taaaaaagca atgcaaatcc aagaacagaa agtacaactt gaagaaagag tagttaagtt   1560
 acggcatagt gaacgagaaa tgaggaacac actagaaaaa tttactgcaa gcatccagcg   1620
 tttaatagag caagaagaat atttgaatgt ccaagttaag gaacttgaag ctaatgtact   1680
 tgctacagcc cctgacaaaa aaaagcagaa attgctagaa gaaaacgtta gtgctttcaa   1740
 aacagaatat gatgctgtgg ctgagaaagc tggtaaagta gaagctgagg ttaaacgctt   1800
 acacaatacc atcgtagaaa tcaataatca taaactcaag gcccaacaag acaaactttg   1860
 ataaaataaa taaagcaatt tagatgaatg tgcttctgct attactaaag cccaagtagc   1920
 aatcaagact gcttgacaga aaccttcaaa agggcacaag aactctgtct tgccgtacag   1980
 agaaagaaat aaaagatact ggagaaagag gtggatgacc taacagcaga gctgaaaagt   2040
 ctttgaggac caaagcagca gaggtcgtaa agaatacaaa tgctgcagag gaatccttac   2100
 cagagatcca gaaagaacat cgcaatctgc ttcaagaatt aaaagttatt caagaaaatg   2160
 aacatgctct tcaaaaagat gcacttagta ttaagttgaa acttgaacaa atagatggtc   2220
 acattgctga acataattct aaaataaaat attggcacaa agagatttca aaaatatcac   2280
 tgcatcctat agaagataat cctattgaag agatttcggt tctaagccca gaggatcttg   2340
 aagcgatcaa gaatccagat tctataacaa atcaaattgc acttttggaa gcccggtgtc   2400
 atgaaatgaa accaaacctc ggtgccatcg cagagtataa aaagaaggaa gaattgtatt   2460
 tgcaacgggt agcagaattg gacaaaatta cttatgaaag agacagtttt agacaggcat   2520
 atgaagatct tcggaaacaa aggcttaatg aatttatggg caggttttta tataataaca   2580
 aataaattaa aggaaaatta ccaaatgctt actttgggag ggggacgccg aactcgagct   2640
 tgtagacagc ttggatcctt tctctgaagg gatcatggtt cagtgttcga ccacctaaga   2700
 aaagttggaa aaagatcttc aacctttcgg gaggagagaa aacacttagt tcattggctt   2760
 tagtatttgc tcttcaccac tacaagccca ctccccttta cttcatggat gagattgatg   2820
 cagcccttga ttttaaaaat gtgtccattg ttgcatttta tatatatgaa gcagtgtggt   2880
 tcctctccaa catcactgca ggaaatcagc agcaggtaca ggcagtaatt gatgccaatc   2940
 ttgtaccaat gataatacac cttttggata agggggattt tggcactcaa aaagaagctg   3000
 cttgggccat aagtaactta acaattagtg gaaggaaaga tcaagtggct taccttatcc   3060
 aacaaaatgt tatcccacct ttttgcaact tgctgactgt aaaagatgca caagttgtgc   3120
 aagtagtact cgatggacta agtaatatat taaaaatggc tgaagatgag gcagaaacca   3180
 taggcaatct tatagaagaa tgtggagggc tggagaaaat tgaacaactt caaaatcatg   3240
 aaaatgaaga catctacaaa ttggcctatg agatcattga tcagttcttc tcttcagatg   3300
 atgtatttaa taattttgta gttttcttaa ttttatatat aaacatagat ctggataaag   3360
 taatatatat aggctcttca ctcatgaagc agactcctag tcctggagtg actgtgtacg   3420
 agagcgtggt tgtggtgctg tatgtgaacg catgcaagct tgattcacct tcagggggct   3480
 ga                                                                  3482



      <210> 1891
      <211> 775
      <212> DNA
      <213> Homo sapiens


      <400> 1891
 atgaggctcc aaagaccccg acaggccccg gcgggtggga ggcgcgcgcc ccggggcggg     60
 cggggctccc cctaccggcc agacccgggg agaggcgcgc ggaggctgcg aaggttccag    120
 aagggcgggg agggggcgcc gcgcgctgac cctccctggg caccgctggg gacgatggcg    180
 ctgctcgcct tgctgctggt cgtggcccta ccgcgggtgt ggacagacgc caacctgact    240
 gcgagacaac gagatccaga ggactcccag cgaacggacg agggtgacaa tagagtgtgg    300
 tgtcatgttt gtgagagaga aaacactttc gagtgccaga acccaaggag gtgcaaatgg    360
 acagagccat actgcgttat agcggccgtg aaaatatttc cacgtttttt catggttgcg    420
 aagcagtgct ccgctggttg tgcagcgatg gagagaccca agccagagga gaagcggttt    480
 ctcctggaag agcccatgcc cttcttttac ctcaagtgtt gtaaaattcg ctactgcaat    540
 ttagaggggc cacctatcaa ctcatcagtg gttcaaagaa tatgctggga gcatgggtga    600
 gagctgtggt gggctgtggc tggccatcct cctgctgctg gcctccattg cagccggcct    660
 cagcctgtct tgagccacgg gactgccaca gactgagcct tccggagcat ggactcgctc    720
 cagaccgttg tcacctgttg cattaaactt gttttactgt tgattaaaaa aaaaa         775



      <210> 1892
      <211> 2177
      <212> DNA
      <213> Homo sapiens


      <400> 1892
 cggcttcgtg gaagcgggcg aggagtgtta ctgcgtttcc tggccaggag tgccgcgacc     60
 tctgctgctt tgctcacaac tgctcgctgc gcccgggggc ccagtgcgcc cacggggact    120
 gctgcgtgcg ctgcctgctg aagccggctg gagcgctgtg ccgccaggcc atgggtgact    180
 gtgacctccc tgagttttgc acgggcacct cctcccactg tcccccagac gtttacctac    240
 tggacggctc accctgtgcc aggggcagtg gctactgctg ggatggcgca tgtcccacgc    300
 tggagcagca gtgccagcag ctctgggggc ctggctccca cccagctccc gaggcctgtt    360
 tccaggtggt gaactctgcg ggagatgctc atggaaactg cggccaggac agcgagggcc    420
 acttcctgcc ctgtgcaggg agggatgccc tgtgtgggaa gctgcagtgc cagggtggaa    480
 agcccagcct gctcgcaccg cacatggtgc cagtggactc taccgttcac ctagatggcc    540
 aggaagtgac ttgtcgggga gccttggcac tccccagtgc ccagctggac ctgcttggcc    600
 tgggcctggt agagccaggc acccagtgtg gacctagaat ggtgtgccag agcaggcgct    660
 gcaggaagaa tgccttccag gagcttcagc gctgcctgac tgcctgccac agccacgggg    720
 tttgcaatag caaccataac tgccactgtg ctccaggctg ggctccaccc ttctgtgaca    780
 agccaggctt tggtggcagc atggacagtg gccctgtgca ggctgaaaac catgacacct    840
 tcctgctggc catgctcctc agcgtcctgc tgcctctgct cccaggggcc ggcctggcct    900
 ggtgttgcta ccgactccca ggagcccatc tgcagcgatg cagctggggc tgcagaaggg    960
 accctgcgtg cagtggcccc aaagatggcc cacacaggga ccaccccctg ggcggcgttc   1020
 accccatgga gttgggcccc acagccactg gacagccctg gcccctggac cctgagaact   1080
 ctcatgagcc cagcagccac cctgagaagc ctctgccagc agtctcgcct gacccccaag   1140
 cagatcaagt ccagatgcca agatcctgcc tctggtgaga ggtagctcct aaaatgaaca   1200
 gatttaaaga caggtggcca ctgacagcca ctccaggaac ttgaactgca ggggcagagc   1260
 cagtgaatca ccggacctcc agcacctgca ggcagcttgg aagtttcttc cccgagtgga   1320
 gcttcgaccc acccactcca ggaacccaga gccacattag aagttcctga gggctggaga   1380
 acactgctgg gcacactctc cagctcaata aaccatcagt cccagaagca aaggtcacac   1440
 agcccctgac ctccctcacc agtggaggct gggtagtgct ggccatccca aaagggctct   1500
 gtcctgggag tctggtgtgt ctcctacatg caatttccac ggacccagct ctgtggaggg   1560
 catgactgct ggccagaagc tagtggtcct ggggccctat ggttcgactg agtccacact   1620
 cccctggagc ctggctggcc tctgcaagca aacataattt tggggacctt ccttcctgtt   1680
 tcttcccacc ctgtcttctc ccctaggtgg ttcctgagcc cccaccccca atcccagtgc   1740
 tacacctgag gttctggagc tcagaatctg acagcctctc ccccattctg tgtgtgtcgg   1800
 ggggacagag ggaaccattt aagaaaagat accaaagtag aagtcaaaag aaagacatgt   1860
 tggctatagg cgtggtggct catgcctata atcccagcac tttgggaagc cggggtagga   1920
 ggatcaccag aggccaggag gtccacacca gcctgggcaa cacagcaaga caccgcatct   1980
 acagaaaaat tttaaaatta gctgggcgtg gtggtgtgta cctgtaggcc tagctgctca   2040
 ggaggctgaa gcaggaggat cacttgagcc tgagttcaac actgcagtga gctatggtgg   2100
 caccactgca ctccagcctg ggtgacagag caagacccct gtctctaaaa taaattttaa   2160
 aaagacatat tacactt                                                  2177



      <210> 1893
      <211> 640
      <212> DNA
      <213> Homo sapiens


      <400> 1893
 gcggccgcgc gaaccttctg gtacaagctg ttcccgtgca gaggatctgg gggggctgca     60
 aaagctgcag aacagaaaag gcaagtcggg ggcagggctg agcctggcac cgctgctccc    120
 tgtggagcac ggtgccctgg gcccactcca gggtggcaag ttcctgccac caaggccctt    180
 ctgtcacagc caatgggatg ccctcctcca ggaccctgca gaggccacac ctgagcagac    240
 cctcagctcc ccctcaccca tgccccacag aggcgagact ctctccacag caaccacctc    300
 gtctccccca gggtcggcaa cccctggtgc ctgagcgggt gtggcctccc cgaagcccac    360
 tctccctgcc ccaggtgcac cagggacccc tcagaggctt ccggggcctg gagggagaaa    420
 ccagcgttct tatcacagcc tgaaagctcc acctagcccc acccaacccc agtctcagcc    480
 gcctcgagct cccctgctct gagagttcct gtcatgatga actggggctt ctttccttaa    540
 atcttccggc cccagggccc cccaagccta cacctggggc cgcggcatcc tttcagggct    600
 caggctgaga gctgtgcctc tgagaacccc tcgacccggg                          640



      <210> 1894
      <211> 651
      <212> DNA
      <213> Homo sapiens


      <400> 1894
 atgaacagag gtggttttgc ggtaaagatc cttgcactgc tggatgctct gagtacagtg     60
 tgcagtcaga gggtgcagaa ggccaagaag cagcagcacc tgcagaataa agagcatttt    120
 aaagcactcc tcaagcagaa ggagaagctg aagcagcaag aggacctcag aagaagctct    180
 tctgaattca gggcatcagg tgcccccaag cgacccccca ccacgggcag tgcagcctct    240
 gatagtgcac ctaccccacc acctttctac caccctggcc atgctgcagt ctccgtcaca    300
 gccagcaact gcagtgaggc gagccacgat gccacaggct acagcctcca gggtttttct    360
 ggctttgccc acactgctgc ttcctaccag gagaaggagg atccacctgc tggatattgg    420
 aggctggagg ctggagcctg tggtcctgca gcttgcctcg ctcggctgct ctgggtccct    480
 gaaagagggt gtggtgtgga cgatctgggt tctgaatcgg attttgttga gtctgggttt    540
 tatacgtcca ctagagctgc ccgaggcttt gcgccctgga tccttggctt tgcctccgac    600
 ccacccctca gccgagtggt gatggtggtg atggtcccct ccatcttcta g             651



      <210> 1895
      <211> 908
      <212> DNA
      <213> Homo sapiens


      <400> 1895
 tttttttttt ttcattcaac actggctagg aatttattgg ctaacaaaat acaagtgatt     60
 tcctggtccc caatccagat tctccacctc ttcttcactt ctgactgatg gaatgcataa    120
 gaactaagat cttgagatgt tatttgaggg cagccttgct tgggtgtggt ctatcatagc    180
 tcctctgact accgccgttg ctacctggct gcaaatgatt gttgtcaagg atagagggtc    240
 cttcagaatt cctgggagat cagaatcagt ctctgaggtg tgggccagtt gtcatggtga    300
 ttattctgtt gtagcatcac tttatgaact aaattaaaaa aatcttcagt cacatctgtt    360
 cagtaggagc catttccttt ggagtcagga cacgcgagaa gggcttcaaa gtgttgccta    420
 cccttctatt cctttgactt ctcctccttt tggtcaaatg actgattaca gagatgattc    480
 ccaaacccgt gatcagtatg caaatgatga gaatggacgt cctggagcgg tcagccttgc    540
 ggacaacttt gggagccttg cagcttctgg ttttgttgcc tgataggtct ttcccagacc    600
 aaaagtcatt ggccagggtt cctttgtcgt cagttacaat cagctctgta aaatccatgt    660
 catccctggc aaagtcccgc tggatgccac accagtacca gcccgtgtcc tctttggtca    720
 ggcaggacat agtgacaatg agctggttcc ctgtgtccct cagggccaca tgattggtgc    780
 tgttagggga gaaggcgatg atgttgcagt agtcacggaa atagcctcgg caccagtatt    840
 tggggtgatt cttgtagtgg gcattgtagt tgcagatggc agaagccgtg tccagcacaa    900
 agcttctc                                                             908



      <210> 1896
      <211> 870
      <212> DNA
      <213> Homo sapiens


      <400> 1896
 ttcaggtgga gtctgttagt ttttgagaaa gagttagggc gagtttaagg cactgtggca     60
 gctgtgagat aaagtctggt tcctccccag ctggctcagg aaatgttcgc ggatacaacg    120
 gcggccccct ctgggcatac ctgcctgtgg agcggagagt ggacggtgtg agggggaccg    180
 ggagaggcac caaatctggc ctgggggccc gagaagcttc ctctcagtga ccacaatatg    240
 aatgggaaca gcaagatggc aaaagcttgc tgagtggtac agcgccagcc tgggtagtgg    300
 cctccccagc aagttgcatg tcactagctt cctgtggctg tcactcctgg gcccaggcac    360
 ctccgaagat cagcacctcc tcatgggctc aagcgaggac aggagcccgt cacccatgag    420
 ctctcaaggg cagagccact gtcctgtctc gatggctcca ccgtgactcc agtggacttt    480
 ggacagtggg gagcaggccc aacagggcca ctcggatgtg gtcactctgg atttgggtgg    540
 atcagcacca agctagactc atccccagcc cccaggtgct gttgctgctc ctgcgtgaga    600
 ccccatccac agctgcagct gtggcagggt ggctagtggt ggccagcatg gccctgctgc    660
 agctccacgc tgtggggggc gtggccctga ccagcagcca ccccttcatg tgggccacag    720
 gggaggagct taggaagccg ccttggcaag gttccgcagg ctctgcgtct ggtgtggaag    780
 agctcacggg gaagcactcc tgcccaggac ccgaggagcc ggccaccgtt cagaaggccc    840
 cagcttgaag gcctggagag ccgcccagct                                     870



      <210> 1897
      <211> 1031
      <212> DNA
      <213> Homo sapiens


      <400> 1897
 tgctacgtgg aaagtctcag atgtattacg cctttgctca gcttaccatg aacacttcct     60
 aatgtaatat ccccagcagc agaagacaga aatgatgatt ctgtataaag atacttggct    120
 ttcagcaaac catcttcggt agatacagta acagaacttc cctgcagttt atctatggtc    180
 acagcacttt tatctgatgc atgaatatct atatttccat aaactgttcc cagacagatc    240
 acttcgcctc cttttgtttg aacatgcaat ttttgaccct taacagactg caagatacta    300
 gtcccatgct ctgtttcaat tttgcaatta tcaccctcaa tactttgaac ttttacacag    360
 ccagaccctg atgacttgat atctaaacct ccacggacgc ctgggggtgg atagtatcag    420
 acacaatggc catctcctcc agatcctcgt cgtacttcac ctgcaggccg tccaggcccc    480
 gcacgccgcc ctccacgccg cacaccgcga ccagcacgcg gtcgccatcc gggtaggtga    540
 gggggtccag gggcctcacg gccaggtggc acgggagccg cgcccgcagc cgaccaaacg    600
 ggctcacctg cagtgtccac tccttcagag ttcggcgcgc cgggccaggc ggagggacct    660
 cagtctccga tccgggccag cgctcgctcc cacctgagct gtacggcctg gcttggcaag    720
 cccagcaagc ccagcgccca gcgccagccc acagtcggac ctgacggaga cagagacgga    780
 agcagccaag ctcccaacct gagcaggggg caagcatggc gcgcctctct cgccagtcct    840
 cagaacactt cagccacagg gagggtcact tgccacggcc aatcgacttg gccactgtgc    900
 cgcctcaagt caaataggag acgtaagtca gggtttgctg aaacaagagc gagccggttg    960
 gcttgactag gcgttctaaa catcagccgc gcaatcccca ggggcaagtt gggatttgaa   1020
 agctcacgaa a                                                        1031



      <210> 1898
      <211> 1031
      <212> DNA
      <213> Homo sapiens


      <400> 1898
 tgctacgtgg aaagtctcag atgtattacg cctttgctca gcttaccatg aacacttcct     60
 aatgtaatat ccccagcagc agaagacaga aatgatgatt ctgtataaag atacttggct    120
 ttcagcaaac catcttcggt agatacagta acagaacttc cctgcagttt atctatggtc    180
 acagcacttt tatctgatgc atgaatatct atatttccat aaactgttcc cagacagatc    240
 acttcgcctc cttttgtttg aacatgcaat ttttgaccct taacagactg caagatacta    300
 gtcccatgct ctgtttcaat tttgcaatta tcaccctcaa tactttgaac ttttacacag    360
 ccagaccctg atgacttgat atctaaacct ccacggacgc ctgggggtgg atagtatcag    420
 acacaatggc catctcctcc agatcctcgt cgtacttcac ctgcaggccg tccaggcccc    480
 gcacgccgcc ctccacgccg cacaccgcga ccagcacgcg gtcgccatcc gggtaggtga    540
 gggggtccag gggcctcacg gccaggtggc acgggagccg cgcccgcagc cgaccaaacg    600
 ggctcacctg cagtgtccac tccttcagag ttcggcgcgc cgggccaggc ggagggacct    660
 cagtctccga tccgggccag cgctcgctcc cacctgagct gtacggcctg gcttggcaag    720
 cccagcaagc ccagcgccca gcgccagccc acagtcggac ctgacggaga cagagacgga    780
 agcagccaag ctcccaacct gagcaggggg caagcatggc gcgcctctct cgccagtcct    840
 cagaacactt cagccacagg gagggtcact tgccacggcc aatcgacttg gccactgtgc    900
 cgcctcaagt caaataggag acgtaagtca gggtttgctg aaacaagagc gagccggttg    960
 gcttgactag gcgttctaaa catcagccgc gcaatcccca ggggcaagtt gggatttgaa   1020
 agctcacgaa a                                                        1031



      <210> 1899
      <211> 1031
      <212> DNA
      <213> Homo sapiens


      <400> 1899
 tgctacgtgg aaagtctcag atgtattacg cctttgctca gcttaccatg aacacttcct     60
 aatgtaatat ccccagcagc agaagacaga aatgatgatt ctgtataaag atacttggct    120
 ttcagcaaac catcttcggt agatacagta acagaacttc cctgcagttt atctatggtc    180
 acagcacttt tatctgatgc atgaatatct atatttccat aaactgttcc cagacagatc    240
 acttcgcctc cttttgtttg aacatgcaat ttttgaccct taacagactg caagatacta    300
 gtcccatgct ctgtttcaat tttgcaatta tcaccctcaa tactttgaac ttttacacag    360
 ccagaccctg atgacttgat atctaaacct ccacggacgc ctgggggtgg atagtatcag    420
 acacaatggc catctcctcc agatcctcgt cgtacttcac ctgcaggccg tccaggcccc    480
 gcacgccgcc ctccacgccg cacaccgcga ccagcacgcg gtcgccatcc gggtaggtga    540
 gggggtccag gggcctcacg gccaggtggc acgggagccg cgcccgcagc cgaccaaacg    600
 ggctcacctg cagtgtccac tccttcagag ttcggcgcgc cgggccaggc ggagggacct    660
 cagtctccga tccgggccag cgctcgctcc cacctgagct gtacggcctg gcttggcaag    720
 cccagcaagc ccagcgccca gcgccagccc acagtcggac ctgacggaga cagagacgga    780
 agcagccaag ctcccaacct gagcaggggg caagcatggc gcgcctctct cgccagtcct    840
 cagaacactt cagccacagg gagggtcact tgccacggcc aatcgacttg gccactgtgc    900
 cgcctcaagt caaataggag acgtaagtca gggtttgctg aaacaagagc gagccggttg    960
 gcttgactag gcgttctaaa catcagccgc gcaatcccca ggggcaagtt gggatttgaa   1020
 agctcacgaa a                                                        1031



      <210> 1900
      <211> 2023
      <212> DNA
      <213> Homo sapiens


      <400> 1900
 tttttttttt ttgaaggcaa aagtgtttat tcaagacttt ctaccacact gtgggaagca     60
 tcgataaaca gtcataataa ttatcattct gagtcactgc aagcgtgggg ttggatgctg    120
 gctctcacag tagcctgtgt tgggaccatg agcagccatg cgcacctcca cgcacggccg    180
 agctcaaccc gaagaccacg cgtgctccct ggcaggagca ggaggcctga ccacagacgc    240
 agcagctccc cagcctgagc ctgggagtgc accagccagc tcgcagcgga ggccgtttct    300
 cctcacaggc tggagtgagc tcagagtcta gaggtcagag gacctcagac taagagctgc    360
 aacagaacga cagcaagaac attctggaaa cgatgccaca gtgaatcttt tatactgtca    420
 ctcacacttg gtgagggcct cagacatgaa accctgggga gaggcgagtg tgacctccag    480
 agtttggctg ggatgcggct gagacagacc tgctgctggc cgaggagggc agtggctggc    540
 gtggccctca tggccagcag gtgctaggac tcctctggag gcccaggcgc ctgtctaagc    600
 tgccggctgt ggaccacctg cagagctccc cccgcagcct ggcggagctg ggcatccagg    660
 gcgccacgga ggtcgttcac ctggacatca ggcagggggt taaggccaat gatgacccca    720
 tccctcgggg ccagctgacc ctctgcatga gggccaaggt cccgccgtcg cctccggagg    780
 tcggagccag cctgcagttt caggtcccgg ttgggcttgg cattgtccgg cctctggccc    840
 cccgggacag ctcgtttgag ccccagctct ggctctggcc tctgcctggg ctcctggaca    900
 gcagcgtcct ccccgcctct cggctgctcg tgggacacag gcacatggtc ccccccgcgg    960
 gcctttctca tctccaggtg accgccatgg tccagccggt ggccctgctg tccaccctgc   1020
 tcgccatcag agatgacccg cagttccggc tggcgtaaca cagcctgggg ctgtgcagct   1080
 gctccttccg ccccaccggg caggtccgct gcaaggccca ggtctcggct cacttgcttg   1140
 ggcttcatgc gagggtcccc cgtctctgct cctggccctg ccacgagcca gttggcttcc   1200
 ttcagaatgc tggtgccagt ggctgccacc tccttcccag gttttttcct gtcttgggaa   1260
 ccgccagtaa cgtcctgact ttgcccaggg aattcctctg cgaggcgctc ctctgggccc   1320
 ccggcttccc tggcggggtc tggcacgggc acctgctccg ggcccttggg gagctccttc   1380
 acagtgccag ctgccctggg ggcggcatcc ttctggccat ctctcagctt gccctgggct   1440
 gcccgaggct ctgtgtcagg gccgccgtca ggagggccag cagggtctct gcccacaggc   1500
 ccctcagagt gctccaggga gcgctggtta aggtcctggg atggagcagg gcggccccca   1560
 ggagctctga ggacagggtc caaaggcagg ggaggcagat tctccaccgt ctccctggcc   1620
 ttgccttcag gggcctcctg gcctctgggc accgctgccc cgggctcttg atgcacctcc   1680
 acctgcctgg gtttatcctc ctcgtcctcc tgcctctgct ggtggatctc cttgtgctgc   1740
 tcctcgatca ccgccagcag cttctcctgc tggtccagca agcgcttttg ctgcacctgc   1800
 tgttctttga tcacctgaag caggacggcg tggtccagca tctccgccct gccagcttcc   1860
 tccagctggc tggccgcctg gtttccaccc gctcgctcca cgtccctctg ctcgcgaggc   1920
 tcgggcgggc agcccaggcc ctggagccgg cttctccgct gggaggggag gcttcccacc   1980
 gtggtcgctg tcctctgcgg gctgccctgt gtccccggcg gcg                     2023



      <210> 1901
      <211> 1415
      <212> DNA
      <213> Homo sapiens


      <400> 1901
 tttttttttt ttcacactgt cacaatttat tgaaatttta taaaaactca ggccaagtgg     60
 aagaataagg tacaactcaa gagtacaaag acaactccgt ttccgttcag tacttttctc    120
 ctcagcactg gtggtaagaa agccccttgc tctctagtag ccaggcagca tggacttaca    180
 gtcttaaaat gaggctttat gtatttcagg ctggaggcag gttgcctttt ctcctgagga    240
 atctcaggca gggtaaaagt tacttaccac tcagtacctc tgtgccagaa gaaaagctca    300
 atttattcaa tccttagaaa agttactatc gtcccctggt cagacactaa ggtgtcttga    360
 taaggtccag agacaaccac atagtcctta ttctaattcg tagtgaaaag gctgcaggca    420
 tatggtgctc ctacgatggg cctgaccctt tcctaagcac atctcatttc cacatccttt    480
 gccttctctt tcccccaaca tttccagcca gcatagaacc caatttctgg gaaattgaga    540
 ggagaaacag tattatgaac acagactcct ttcaaattgg aacaggagcc aaaccaaata    600
 aataagagaa ttgtgtaggg aagtggggta gaagggaggt cagggagcaa tcccttgcct    660
 caagtctggt gcacctcatg gaacatcagt tcacggggga tggctgtttc tggaccaaac    720
 ttggtggctg cccgacgctc aaaggcagca acattctgtt tgacaacctc atcaaaaaac    780
 atggtggcca gctgggagtg cagcagagaa cgaaattcaa aggaaatcga aaagtccaca    840
 gtgcaggttc gaggataggc aggaatacca gggctgaatc gccaaatagt ctctaagtgg    900
 ttgaagagct tgccatcagt acaaacagcc ttgaccatgt gaggtttgac catggaaact    960
 gcagaggtgt aacgttccat gacaggtgga aagccaacct ccagctgggc tttcaaatga   1020
 cccttacggc tggataccac cagagacttc ttaccccagg gcacaaactc acgatactcc   1080
 tggacgttgg acaccacctc atacatctcc tgcattgagt accccatgat tctacgctcc   1140
 gagtaagcct ttcgcttgtt ggtgaaggga gcagcaaatc ccatgaagga acggctcgaa   1200
 ggtaagccag cctcagccgc caagatctgg gcagcccgag gcaagaggag gctgcaggag   1260
 gtcagaaacc ccgagaactt cccttctcgt acaacttgca aaagcattat ccaaagctct   1320
 acgttagctc ccagggcatg attgctgcca gtccccgccg cgcctgcatc ccagtatagc   1380
 acccctccac cgcggaaccc cggggttcgc agcga                              1415



      <210> 1902
      <211> 1208
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1208)
      <223> n = a,t,c or g


      <400> 1902
 tttttttttt ttgtgtgtat aaaaaagtga tatgtcttta atttaaaatt atgacccgga     60
 aataactagt cagtttaagt gatccagact tcctcttcat acccaaatgg aacagacaca    120
 atattggctc agatttccaa ccccagaaaa aaaccaaacc aagtcctcag gaagtccctg    180
 cagcgacctt gctggggcca tcagaccgca cagagtggag gtgcccaagc tgctaggctg    240
 ctcttaatcc agccacactg agaagagctt tccttctacc agcaactccc tcgctgggtc    300
 cgatatcccc cttcacctcc cttttagctg gcactgcacg aatgcctcca cagagaggct    360
 gacagtacag cagtcacctc ccagctgtct tcggtgcatc ttcagggcca ccttcctgtg    420
 gtcacaatag aggagttgag cattctaaac gttcgtgccc aggagggcag cgtcttctct    480
 ttttagctga ggtctggagc cctgagttgt aaccattggt catatgtggc tgaggcaccg    540
 acagcaaatc gccaaacttg ggaaacgatc tggggagatg caagggcctt ggtaattgat    600
 ggtgagtaag tccatggagt tttcatccca tcatggcaga aggctggcct gacccctgcc    660
 ctcactggat gatgctgtct ggctgcccat tctgggccac ctgcccaggg tcagaggcgg    720
 gggccgggtt agctgtgttg ctctgcaggt agcggcggaa atctttgatc ataggccgga    780
 ggacctggat gaggacgctc agggcagcct gtgtgccctc catggcctgg gcctggcgct    840
 cctgggcaca ggcctgcact tcctgggagc ggcggatcat ctgcagtagg tcgttctgct    900
 gttccaggtg ctgtgcgatc tccttcacat gcaggttggt gacccgctgc tcctgtatca    960
 gcttggcgga gttgagagca atgcggctct tgagcgcttg cggcttgacc gacgtgtctg   1020
 catgctgggc catcatgtcc acaggggtct ctggtggcag aggtgggggc gcctcagccg   1080
 tgcagtactc caccacgccc tcctccagcg tgtgataggt ggtctctgtg gggatctgtg   1140
 tcagggaatt ccacgcnntg tactgatgaa ttctatactc aattgnnnnn ggcccgcctc   1200
 ccttccct                                                            1208



      <210> 1903
      <211> 1215
      <212> DNA
      <213> Homo sapiens


      <400> 1903
 cgtcgaacaa ttgtaaatac gcctcaacta tagggcaaaa atttttttac acactatata     60
 tatctttttg tatttatttt tttgtgagca acaaggctat ttatttcacc tgggtgcagg    120
 cgggctgaat ccgaaaagag agtcagcgaa gggagatagg ggtggggcca ttttatagga    180
 tttggttagg tagtggaaaa ttacagtcaa agggggggtt tttctctggt gggcaggggt    240
 ggggtgtcac aaggtgctca gtgggggtgc tttctgagcc aggatgagcc aggaaaagga    300
 ctttcacaag gtaatgtcat cagttaacgg caggaacaag gccattttca cttcttttgt    360
 ggtggaatgt catcatttaa ggcaggaacc agccatctgg atgtgtacat gcaggtcaca    420
 gaagggcggg aagactacaa tcccagcatg cacctggcta agagacagtt cctgtcactg    480
 gaggaagagg cggaagacta caatcccagc cagcaccggg ctcagggaaa ttggctgcag    540
 gactacaatg ccagcatgca gcgggttcat ggacagtgtg tatcactgga ggaagacgtg    600
 gagctgtgcg tgcctcgctg ggcttgcagg gagatgcagt ctcataacta ccccagtcgt    660
 ttggtcgcag ggctgcagca gtacaatttc agcatatctc tggctcaggg agagtgcact    720
 agtcactgga ggaagagggg tattatgaca tactcttcta ttcattgcct aggcgatgtg    780
 actctccact cttacctggg cccttccaaa acagaggatt gtgacatatc agtgacccta    840
 ccaccaaggc tggagaggag aatcacatta cctaagcact ggatcaagaa atacttcaca    900
 atctttctca tgggcaaagc ccagattaac aaaatagata gaccactagt aagacaaata    960
 aaggagaaaa gagagaagaa tcaaagagac gcaataaaaa acgacaaagg ggatatcacc   1020
 acgaaaccca cagaaataca aactaccatc agagaatact ataaacacct ctacggaaat   1080
 aaagtggaaa acctagaaga aattgataaa ttcctggaaa catccacacc tccaagacta   1140
 aacgaggaag aagttgaatc tctgagtaga ccaatagcag gttctgaaat tgaggcaata   1200
 attaatagct tatga                                                    1215



      <210> 1904
      <211> 1428
      <212> DNA
      <213> Homo sapiens


      <400> 1904
 atggggtccc gggtccgcct tagtaagcgc cgggccaagg ctggggttca gtcaggcacc     60
 aacgccctgc ttgtggtcaa acatcgggac atgaatgaga aggaactgga agctcaggag    120
 gcacggaagg cccagctaga aaaccacgaa ccggaggagg aagaggaaga ggagattaga    180
 cagccgagaa agaagctggg ggctcagccg gtggtgcact gggtggcacc tgatgggcgg    240
 ctgctgggga actccagccg gacccgggtc cggggggacg ggacgctgga tgtgaccatc    300
 accaccttga gggacagtgg caccttcact tgtatcgcct ccaatgctgc tggggaagcg    360
 acggcgcccg tggagcccag aggcctgtgc ccggactacg catgtaccag gttcagtaca    420
 acagttccgt tgatgactcc ctcgtctaca ggggttgata tagaagcagc tcgaaaggaa    480
 gaagaacgga tcatgcttag agatgccagg cagtggctaa atagtggtca tataaatgat    540
 gtccggcatg caaaatctgg aggtacagca cttcacgttg cagctgctaa aggctatacg    600
 gaagttttaa agatcatctc tttacgtttt ggtgtccccc gaacccaggt caggacatgg    660
 gttgccctct atgaaaaaca tggagaaaaa ggtttaattc ccaaacctaa aggcgttagt    720
 gctgatccag agttgcgtat taaggtcgtg aaagctgtga tcgagcagca catgtccctt    780
 aatcaggctg ctgctcactt tatgcttgct ggtagtggtt ctgtagccag gtggctgaag    840
 gtctatgaag agcgcggaga agctggttta cgcgcgctca agattggcac caaaagaaac    900
 attgcaatat cagttgatcc agaaaaagcg gcatcagcat tggagctgtc aaaagaccga    960
 cgcattgagg atcttgaaag gcaagttcga tttcttgaaa cgcggcttat gtatctaaaa   1020
 aagctgaaag ccttagctca tcccacgaaa aaggctgcgg agataccgcg cagtacgttt   1080
 tattatcatc taaaggctct cagcaagcct gacaagtatg cggacgttaa aaagcgtatt   1140
 agtgagattt atcacgagaa tagaggccga tacggatacc gtagggtaac gctgtctctt   1200
 catcgagaag ggaaacagat taaccataaa gctgttcagc gcctgatggg aaccctctca   1260
 cataaagcag cgattaaggt caagcgatac cgctcttaca gaggagagat gaagaaactg   1320
 agaatcagag aggttcagat acttgctgga ggtcacacag ctaagttgaa tatggagcaa   1380
 gtgaaatctg cagatgcttt cacgtatatt aagcagccaa ttgcttaa                1428



      <210> 1905
      <211> 417
      <212> DNA
      <213> Homo sapiens


      <400> 1905
 tttcgtttct aactgaagag gagagaaccc tatccagggg ggccttgaga gacatgctgg     60
 atcaagtcta tcagccctta gcagtccggg aactgcttat cctccaggga ggaccacccc    120
 agatcatact ggggcaggaa agaaatacaa aagaaatccg gccgggcgcg gtggcgcact    180
 ttgggaggct gagtcctgca cagatgtgaa gacacagatg aggtgtcggg ccccagcttg    240
 gcttcggcgt ctatgtggac agctgctctc tgaaaggtta atgagaccta atggtgttca    300
 ggcagtagtc cggggcattt tggaaggagc aggtgcggga gcagctggtg gaagtgatgc    360
 tgaggtgacg gctgctgact ggaaaaagtg tgacctgatc gcaaagattt tggcctt       417



      <210> 1906
      <211> 817
      <212> DNA
      <213> Homo sapiens


      <400> 1906
 tttcgtgggc cactgcaggg gccgctaacg gtccggcgcc cctcggcgtc cgcgcgcccc     60
 cagcctggcg gacgagcccg gcggcggaga tgggggcgac gggggcggcg gagccgctgc    120
 aatccgtgct gtgggtgaag cagcagcgct gcgccgtgag cctggagccc gcgcgggctc    180
 tgctgcgctg gtggcggagc ccggggcccg gagccggcgc ccccggcgcg gatgcctgct    240
 ctgtgcctgt atctgagatc atcgccgttg aggaaacaga cgttcacggg aaacatcaag    300
 gcagtggaaa atggcagaaa atggaaaagc cttacgcttt tacagttcac tgtgtaaaga    360
 gagcacgacg gcaccgctgg aagtgggcgc aggtgacttt ctggtgtcca gaggagcagc    420
 tgtgtcactt gtggctgcag accctgcggg agatgctgga gaagctgacg tccagaccaa    480
 agcatttact ggtatttatc aacccgtttg gaggaaaagg acaaggcaag cggatatatg    540
 aaagaaaagt ggcaccactg ttcaccttag cctccatcac cactgacatc atcgttactg    600
 aacatgctaa tcaggccaag gagactctgt atgagattaa catagacaaa tacgacgggt    660
 gagtaagccg tctttcatcg ccatcaagtc cattgttaat gaaaaagttc tacccacctc    720
 tcagttttga gagctccttt tcctaaatcc gccccccgcc tccacccacg accaattgta    780
 aaagtaaaca tgcttcttac aggaaggcaa gaaagaa                             817



      <210> 1907
      <211> 1222
      <212> DNA
      <213> Homo sapiens


      <400> 1907
 cagatcctca tctccctggg tagtgaggct catcacagac aagcaaccaa ctgctgggct     60
 gccggtgccc cccatgttgg aacctgagtt ggagattatc tcctaagcag atacctgctt    120
 ccaaactggg gatgtagggc ttggaaacta aaaaatgcca ggtctgaggg agaggaaaga    180
 acaagtccag caatacacag agctctgtgt attcagaggg aagttggcag ggttgtgttc    240
 gggcagagaa actccgagtg gtacaaaggg gacgtgccca gagtggagaa atcatgctaa    300
 ttgtctgcac tagagctgga gaacgccacc caaaatgaag agagaaaggg gagccctgtc    360
 cagagcctcc agggccctgc gccttgctcc ttttgtctac cttcttctga tccagacaga    420
 ccccctggag ggggtgaaca tcaccagccc cgtgcgcctg atccatggca ccgtggggaa    480
 gtcggctctg ctttctgtgc agtacagcag taccagcagc gacaggcctg tagtgaagtg    540
 gcagctgaag cgggacaagc cagtgaccgt ggtgcagtcc attggcacag aggtcatcgg    600
 caccctgcgg cctgactatc gggaccgtat ccgactcttt gaaaatggct ccctgcttct    660
 cagcgacctg cagctggccg atgagggcac ctatgaggtc gagatctcca tcaccgacga    720
 caccttcact ggggagaaga ccatcaacct tactgtagat gtgcccattt cgaggccaca    780
 ggtgttgggg gcttcaacca ctgtgctgga gctcagcgag gccttcacct tgaactgctc    840
 acatgagaat ggcaccaagc ccagctacac ctggctgaag gatggcaagc ccctcctcaa    900
 tgactcgaga atgctcctgt cccccgacca aaaggtgctc accatcaccc gcgtgctcat    960
 ggaggatgac gacctgtaca gctgcgtggt ggaaaacccc atcaaccagg gccggaccct   1020
 gccttgtaag atcaccgaat acagaaaaag ctccctttca tcaatttggc tccaggaggc   1080
 attttcctcc ttgggacctt ggtgaagacc tggccaacaa gggaaaaccc cgtctttatt   1140
 aaaaatacaa aaaatgcccc cgctttgggt gtaagggcct gttttcccgc gcccttcggg   1200
 aggttttgaa cagtaaatct cc                                            1222



      <210> 1908
      <211> 1222
      <212> DNA
      <213> Homo sapiens


      <400> 1908
 cagatcctca tctccctggg tagtgaggct catcacagac aagcaaccaa ctgctgggct     60
 gccggtgccc cccatgttgg aacctgagtt ggagattatc tcctaagcag atacctgctt    120
 ccaaactggg gatgtagggc ttggaaacta aaaaatgcca ggtctgaggg agaggaaaga    180
 acaagtccag caatacacag agctctgtgt attcagaggg aagttggcag ggttgtgttc    240
 gggcagagaa actccgagtg gtacaaaggg gacgtgccca gagtggagaa atcatgctaa    300
 ttgtctgcac tagagctgga gaacgccacc caaaatgaag agagaaaggg gagccctgtc    360
 cagagcctcc agggccctgc gccttgctcc ttttgtctac cttcttctga tccagacaga    420
 ccccctggag ggggtgaaca tcaccagccc cgtgcgcctg atccatggca ccgtggggaa    480
 gtcggctctg ctttctgtgc agtacagcag taccagcagc gacaggcctg tagtgaagtg    540
 gcagctgaag cgggacaagc cagtgaccgt ggtgcagtcc attggcacag aggtcatcgg    600
 caccctgcgg cctgactatc gggaccgtat ccgactcttt gaaaatggct ccctgcttct    660
 cagcgacctg cagctggccg atgagggcac ctatgaggtc gagatctcca tcaccgacga    720
 caccttcact ggggagaaga ccatcaacct tactgtagat gtgcccattt cgaggccaca    780
 ggtgttgggg gcttcaacca ctgtgctgga gctcagcgag gccttcacct tgaactgctc    840
 acatgagaat ggcaccaagc ccagctacac ctggctgaag gatggcaagc ccctcctcaa    900
 tgactcgaga atgctcctgt cccccgacca aaaggtgctc accatcaccc gcgtgctcat    960
 ggaggatgac gacctgtaca gctgcgtggt ggaaaacccc atcaaccagg gccggaccct   1020
 gccttgtaag atcaccgaat acagaaaaag ctccctttca tcaatttggc tccaggaggc   1080
 attttcctcc ttgggacctt ggtgaagacc tggccaacaa gggaaaaccc cgtctttatt   1140
 aaaaatacaa aaaatgcccc cgctttgggt gtaagggcct gttttcccgc gcccttcggg   1200
 aggttttgaa cagtaaatct cc                                            1222



      <210> 1909
      <211> 3149
      <212> DNA
      <213> Homo sapiens


      <400> 1909
 cacttgattg cagagaaggt ctacagagca gtggttagaa cttggccctg aggacagagc     60
 ttttgctccg tatgaggctg gcaggtaacg atcttctcag ttttctccca ggaattctgg    120
 aacgatgaag gtgatgattg tgcctgtggc caagaccggg agaaccctgg atccctacac    180
 cttccccacc cctggaatgt cactatacat atctgacttc ttctgatgtt gcctttgacc    240
 ctaaagtcaa tatgataaag taacaagaag ctgggacaga ggaacaaaca cagcccactc    300
 aagcagtggt ggcaacattc tgttagaaag gaggggagtc aaagaaaaaa acacccctcc    360
 gcccatctcc ttatcacctc cctaaagaca gaggagaaca tggacaccct ccatcctgat    420
 agacatgcca tgtggtcagt ttgtgcggta aacaggaaaa aaaaaaaacc taaagatatt    480
 gtagaccttt attttcttta aatctcctaa taaaaacatt aaactttcaa gaagattcca    540
 aactgacatt gcatagacca actcctttcc aaaaatatct ctgatatact ctccaactct    600
 ctcaatatat agaatttgaa gtccaggagc tgtgggcacc tggtgggaat tcactgagct    660
 caaggggaca agagggctga ggacagggct cccacatggg gacaaggcca ggctttctgg    720
 cctctggttc cagccagcat caatttggtt gtggccaaat tctcagtcca atcaccctgg    780
 cccagggcct ggcgtgggag gatgtggcag gctctgtctc cttctggggt tcctggtctg    840
 gaggagtctc cccaacagcg ccaaagctgg ctgttttccg cccaaagccc cagaactttg    900
 aatgagaggc aaatctaccc tgaatgcacc tccctcctag gctgggtgag gtcacgcaga    960
 cacagaaggg caggacagaa ctccccatct tctgggggcc aattcgtctg gacactgtgc   1020
 ggtcagcttc ctttttaaag tgccagtatc ggtggggcag gaagggactc tcagggctga   1080
 gcagagcctt ctccagcgcg agcaaacact ctgtcccgcc tcggcaggca ccttctaaca   1140
 ttcattttct aagggttagg tgagtaaaac aacaacaaca aatgctggaa atgctctgtt   1200
 cccaatgcca gggagttcca agaccaagaa gcccaactct caccagcggg ggcagatggg   1260
 gagctaggga aggaaccctc ccagcctggg gagggcacct gcacccctcc cagagagaga   1320
 agcccccatc ccggcccccc agctgggccc cagcgctgct ggaaccagcc ggcaggtggg   1380
 gcagaaaagc agcacctccc ctcaccaggg cgaggaggca atattgaacc gtgaactcaa   1440
 gaagaaagac ggaaagaaaa aatgaaaaaa gctacagggc taagtaaaca ccagcctgct   1500
 gggtttatac aaaatgagtg aaatttaaaa ggggcaggag agtttgtcca gggactggct   1560
 ggcagccaga acccaccttc aagcaagtta caaggacttg ggggaaagtg ctgagagcag   1620
 aggctttagt agggggcagg gccagactgc tccccactgg gaaagcacac cccttaaagg   1680
 agcccttccc ccttgcccag aacgggggat gcttccagag gaaggctgag gcttttctgg   1740
 taaggaagcc agctccggac cagtccagcc acagcccacc tgcctctatg gcatccgccc   1800
 cagtctgggc agctgaccct gagggcagag aaggactttg cttgctccaa ccttcctgca   1860
 ggaaaaccag ctgctcagga cccagccctg ggcagagggc acggtcggtg ctcagacctt   1920
 tctcagcacg ggtctcagac ctgagctgga gctaactgga ggaagaggca gcacccgttc   1980
 ccgccgggct gctggaccct gggcctctga ctgcacagca ggcagtgacc aggagtcctt   2040
 gggaaggagc tcagggaagg ggaggtgagg ggccagtggg actgtgctgg gggtgagcat   2100
 gtgcaaagtg caggctgcaa ggcagcggga ggacatttgc cggggggagg caggggtctc   2160
 gatctggagt gtgggtgggg tctgaggtca tggctcccag gaagaggccg ccagcaggtc   2220
 ccccaggaca caaggaaggg acagctgaag cactaagcag tcagacagtc acaggtggca   2280
 ggattccgga ggcggtctgg cccccccacc accagggcaa gggaacaacg gagcaaggcc   2340
 ctgctgctaa gacgtgacca aagccagtgc tcctggagtg agtggggaca caggtagaga   2400
 ggccccctca gccacaggca tctctacatt taggagctgc tgcatgtcct cagccagagg   2460
 gctgggtcag tctccagcag cgccggtcct tgccagctcc ttcttgccca caagctgcac   2520
 gggcccgcct ggcctgcctg gcctgccctc tagtggttca gaggagaata ttcacagtgg   2580
 tgcctgggcc ttggtgggcc aggagggtcc cagcatggat gggaggggca atggaatgat   2640
 gctacgggga gtgtggactg gagtgcatgg aggaggcatg gatgagatgt ggcgcagagg   2700
 tgatctgaag gggaaagttc ctcatggaat gatacaggtc tggactccag agaaagcagg   2760
 actcttctcc agcccggaca cctgctcctc aatggctttc aatcacaact ggctcgtaga   2820
 ccccagaaga gaccctggtg gcaagctgga tgccgctcag cgtggcagag ccatcgcggc   2880
 tcacgaacag ccggaggttg ctgtcctcgg tgttgctgcc atctgtgaag tcctggctct   2940
 gcacgatctt ctccacgatg gcatccgcat cgatccgcgt gtcgtccacc caggtcgggt   3000
 ggctctccac cgagtccttc ttccgcctga aagagcgatc ggacagatgc aggggccggg   3060
 gtggccgcgg cggcttctcc gggggccggt gctcccgctc actgccctca gggccctcca   3120
 cggtcatgcc aaggccccca gaggcgctg                                     3149



      <210> 1910
      <211> 960
      <212> DNA
      <213> Homo sapiens


      <400> 1910
 atggaaacca gcagcccgcg gcccccgcgg cccagctcca acccggggct gagcctggac     60
 gcccggctgg gcgtggacac tcacctctgg gccaaggtgc tgttcaccgc gctctacgca    120
 ctcatctggg cgctgggcgc ggcgggcaat gcgctgtccg tgcacgtggt gctgaaggcg    180
 cgggccgggc gcgcggggcg cctgcgccac cacgtgctca gcctggcgct cgcgggcctg    240
 ctgctgctgc tggtcggcgt gccggtggaa ctctacagct tcgtgtggtt ccactacccc    300
 tgggtcttcc gcgacctggg ctgccgcggc tactacttcg tgcacgagct gtgcgcctac    360
 gccacggtgc tgagcgtggc aggcctgagc gccgagcgct gcctagccgt gtgccagccc    420
 ctgcgtgccc gcagcctgct gacgccacgc cggacccggt ggctggtggc gctctcgtgg    480
 gccgcctcgc tcggcctcgc cctgcccatg gccgtcatca tggggcagaa gcacgaactc    540
 gagacggcgg acggggagcc ggagcccgcc tcgcgagtgt gcacggtgct ggtgagccgc    600
 accgcgctcc aagtctttat ccaggaagcc atcgtggtca tgtatgtcat ctgctggctg    660
 ccgtaccatg cccgcaggct catgtactgc tacgtacctg atgacgcgtg gactgaccca    720
 ctgtacaatt tctaccacta cttctacatg gtgaccaaca cacttttcta cgtcagctca    780
 gctgtgactc ctcttctcta caacgccgtg tcctcctcct tcagaaaact cttcctggaa    840
 gccgtcagct ccctgtgtgg agagcaccac cccatgaagc ggttaccccc gaagccccag    900
 agtcccaccc taatggatac agcttcaggc tttggggatc ccccagaaac ccggacctga    960



      <210> 1911
      <211> 394
      <212> DNA
      <213> Homo sapiens


      <400> 1911
 gtgaaagtaa gaaaacattt agctggttct gtctgtcagg cttcaaatac atacatttac     60
 agaatgactt ctgactaaat tgtcttagat atgaatgtta ttatctacag atgtgaacct    120
 tttctatcat ttgattgttc taggatgttg aagtcaaatg gattgaatac cagaatatgg    180
 tgaactacct catccaatgg attagacacc atgtgaccac aatgtctgag agaacatttc    240
 ctaataatcc tgtagaactg aaggttagtg tcactgtaga aattacatag gattgattcg    300
 attgtaaacc cttaagtaat gctataataa ttctgtaatt ttagaagttc aacaaaagtt    360
 gcccttggaa agccattaat aagtaggcaa aatt                                394



      <210> 1912
      <211> 394
      <212> DNA
      <213> Homo sapiens


      <400> 1912
 gtgaaagtaa gaaaacattt agctggttct gtctgtcagg cttcaaatac atacatttac     60
 agaatgactt ctgactaaat tgtcttagat atgaatgtta ttatctacag atgtgaacct    120
 tttctatcat ttgattgttc taggatgttg aagtcaaatg gattgaatac cagaatatgg    180
 tgaactacct catccaatgg attagacacc atgtgaccac aatgtctgag agaacatttc    240
 ctaataatcc tgtagaactg aaggttagtg tcactgtaga aattacatag gattgattcg    300
 attgtaaacc cttaagtaat gctataataa ttctgtaatt ttagaagttc aacaaaagtt    360
 gcccttggaa agccattaat aagtaggcaa aatt                                394



      <210> 1913
      <211> 499
      <212> DNA
      <213> Homo sapiens


      <400> 1913
 cccgttctct gccgcccgcc cactccgttt ccctgtggtc cgtgaaggac ggcctcaggc     60
 cttggcatcc tgagcttcgg tctgtccagc cgacccgagg aggccggact cagacacata    120
 ggcggggggc ggcacctggc atcagcaccc cgcacaccct cggaggacgg gcttcggctg    180
 cgcggaggcc gtggcacacc tgcgggaggc agcgacggcc cccacgcaga cgccgggaac    240
 gcaggccgct ttattcctct gtacttagat caacttgacc gtactaaaat ccctttctgt    300
 tttaaccagt taaacatgcc tcttctacag ctccattttt gatagttgga taatccagta    360
 tctgccaaga gcatgttggg tctcccgtga ctgctgcctc atcgataccc catttagctc    420
 cagaaagcaa agaaaactcg agtaacactt gtttgaaaga gatcattaaa tgtattttgc    480
 aaagcctaaa gttaaaaaa                                                 499



      <210> 1914
      <211> 1927
      <212> DNA
      <213> Homo sapiens


      <400> 1914
 cacggcaaga aaataataca cgaggggtcc cttcactgct gaagagcttc ctccaggagc     60
 gactgggaat ccacttaatt cgaaggaaga tagtaaagcc taagcatcat gttttgatgt    120
 ctcggaagga atcatggaag gtgaaaagcg aaatcccaaa ggtgccgaag cagcctctgg    180
 tgctccatca cccgcgcatg acgacaacca agtctccctc aaaggatatg ctagagccag    240
 aggcagagct ggctgaagat ctgcccacta ccaaaagcac ttctgtggag tcagagatgc    300
 ccactgagaa cctggaaggc cattccccgt cttgccggac cttcgtgcca ctgcctccca    360
 tctgctccaa ctccactgtg catagtgaag agaccctgtc ccacctgagt gacacaactg    420
 tccgcctcag cccagagcgc ccatcagatg aggactccaa gagcacagag tccatcttcc    480
 tgacccaggt gagtgaactg ccttcctccg tcatccataa ggatgattta gagttaaagg    540
 agaaagacca aaagaaacca ccaacggcac ccagagaggt gaaagggact cggaggaaac    600
 tcccaactgc cttccttccc agcaagtacc acggctatga agaactgctg acagccaagc    660
 ctgatccagc cttcattgag ccaaagggaa tccagaagaa tgcacaagcc ctgcaacaaa    720
 tgctgaagca cccactcctg tgccactcct ccaagcccaa gctggacact cttcagaaac    780
 cctatgttca caaagagaaa cgggcccaga gaatcccgat tccaccccca aagaagacta    840
 gagcccaact tctggatgac atcttcattc gcttgcggga tccccggaac attacagagg    900
 ctccactagg tgctgtcctg caccagtgga cagaacggcg gctggtgaac cacaagcagt    960
 acctggaggc caagaggctg ttgaaggagt tccaggcacg ttaccggcag ctggtgagtg   1020
 gctctctgcg cacagtgttc gggactaccc cgctccccat ggcctgccca gcgctgagtg   1080
 agagccagcc caagttcggc cacttcctcg agttcatgga tgagttctgc caggagccca   1140
 cagccagtga ctcacaaggc tagagctgtg catgggggct gtgtgcacca cccggcctgt   1200
 gccccagctc tccccgaggg ctctgtgccc tggaccgcac ctcaaggttg accagccggc   1260
 cacaggcctc agagctcagc tgggccccac ttgctggcca caaggtggca tccccttgtc   1320
 aggatctccc ctccttggcc caggcatgac ctggtgcctg gcccagcggc aataaagagt   1380
 gggtgcacag ggcaatagac tgggtgccac atgcattctt tcttggaacc caggccacag   1440
 cagcattgtc acacttccct ctaaaaatgg ttttccagtt cagatgcaac agggatacat   1500
 ttgttctctg ttgtatgaga aactgacacc aaggggatct taacaaattc ctgaacaatg   1560
 gctccaaaaa agggtatttt taaaaaccag atcttgtgag tacagcccta atgtgcaggg   1620
 acagtgtcat cctgtatatt cgttctttac tcagactctt tcttggttcc ttcattagga   1680
 gcatgaatgg ttgaatgtga acatgacagt aaattggagc aaactgtaaa ctggacataa   1740
 cttatgccaa aagacgtagt tgtacaccat ggaaacccca tccctgctcc taatctctac   1800
 tgccattctg aatgccaaag caagacatcc aacatggggc atctcccaga gcacatacag   1860
 caccaaaaat ccacacacag cctaagctta acccatgttt ttgtcttgag attgttcacc   1920
 agagaca                                                             1927



      <210> 1915
      <211> 1927
      <212> DNA
      <213> Homo sapiens


      <400> 1915
 cacggcaaga aaataataca cgaggggtcc cttcactgct gaagagcttc ctccaggagc     60
 gactgggaat ccacttaatt cgaaggaaga tagtaaagcc taagcatcat gttttgatgt    120
 ctcggaagga atcatggaag gtgaaaagcg aaatcccaaa ggtgccgaag cagcctctgg    180
 tgctccatca cccgcgcatg acgacaacca agtctccctc aaaggatatg ctagagccag    240
 aggcagagct ggctgaagat ctgcccacta ccaaaagcac ttctgtggag tcagagatgc    300
 ccactgagaa cctggaaggc cattccccgt cttgccggac cttcgtgcca ctgcctccca    360
 tctgctccaa ctccactgtg catagtgaag agaccctgtc ccacctgagt gacacaactg    420
 tccgcctcag cccagagcgc ccatcagatg aggactccaa gagcacagag tccatcttcc    480
 tgacccaggt gagtgaactg ccttcctccg tcatccataa ggatgattta gagttaaagg    540
 agaaagacca aaagaaacca ccaacggcac ccagagaggt gaaagggact cggaggaaac    600
 tcccaactgc cttccttccc agcaagtacc acggctatga agaactgctg acagccaagc    660
 ctgatccagc cttcattgag ccaaagggaa tccagaagaa tgcacaagcc ctgcaacaaa    720
 tgctgaagca cccactcctg tgccactcct ccaagcccaa gctggacact cttcagaaac    780
 cctatgttca caaagagaaa cgggcccaga gaatcccgat tccaccccca aagaagacta    840
 gagcccaact tctggatgac atcttcattc gcttgcggga tccccggaac attacagagg    900
 ctccactagg tgctgtcctg caccagtgga cagaacggcg gctggtgaac cacaagcagt    960
 acctggaggc caagaggctg ttgaaggagt tccaggcacg ttaccggcag ctggtgagtg   1020
 gctctctgcg cacagtgttc gggactaccc cgctccccat ggcctgccca gcgctgagtg   1080
 agagccagcc caagttcggc cacttcctcg agttcatgga tgagttctgc caggagccca   1140
 cagccagtga ctcacaaggc tagagctgtg catgggggct gtgtgcacca cccggcctgt   1200
 gccccagctc tccccgaggg ctctgtgccc tggaccgcac ctcaaggttg accagccggc   1260
 cacaggcctc agagctcagc tgggccccac ttgctggcca caaggtggca tccccttgtc   1320
 aggatctccc ctccttggcc caggcatgac ctggtgcctg gcccagcggc aataaagagt   1380
 gggtgcacag ggcaatagac tgggtgccac atgcattctt tcttggaacc caggccacag   1440
 cagcattgtc acacttccct ctaaaaatgg ttttccagtt cagatgcaac agggatacat   1500
 ttgttctctg ttgtatgaga aactgacacc aaggggatct taacaaattc ctgaacaatg   1560
 gctccaaaaa agggtatttt taaaaaccag atcttgtgag tacagcccta atgtgcaggg   1620
 acagtgtcat cctgtatatt cgttctttac tcagactctt tcttggttcc ttcattagga   1680
 gcatgaatgg ttgaatgtga acatgacagt aaattggagc aaactgtaaa ctggacataa   1740
 cttatgccaa aagacgtagt tgtacaccat ggaaacccca tccctgctcc taatctctac   1800
 tgccattctg aatgccaaag caagacatcc aacatggggc atctcccaga gcacatacag   1860
 caccaaaaat ccacacacag cctaagctta acccatgttt ttgtcttgag attgttcacc   1920
 agagaca                                                             1927



      <210> 1916
      <211> 1065
      <212> DNA
      <213> Homo sapiens


      <400> 1916
 gaatccctat gttaaacccg tggtttctca tgaattagat cataatttaa cattgtaaaa     60
 tttcagaaac tattgtgcta atatttagat ttcaggaagg aatcagacta aatcaattac    120
 ctccattcat tgttagaaca gaagatataa tagcttacta actgatatga gttatgaatg    180
 tcactatgac acaaaatttg ctgtgatttg ctaatctggc tacaagtgca gtatttttca    240
 tgaatgacaa cacacagcat ttccaacttg taacatgaaa ctccagctca taaagagtgt    300
 attgtgtgac ttgaaaaagt ctgattgtaa ctaagtaaca accgttcccc tgaaaaaacg    360
 aacaaaatcc attaggaaat caggcacaga cggtattgat cggtttttct tcctttcctc    420
 ctgtggtttt gtttctcaag acatataggt ggttccaaca gaagccaaca cttgttacaa    480
 aataacacag ctattttttt ccttttcttt ttctttatct ttttctcgtg gttccttccg    540
 tttacgttca ctattcccag attgtcttcc acttgatgga gaggcttgtg ctggctggcc    600
 ctgctgagcc tgtgtagaag cagcagcagc agcagctgct gcttgttcct gttcctgata    660
 gtattgagaa gcccgtctgt cctcttcctc ttggagtttc tttgctagtt ccaaatcact    720
 gattccttcc gggatttgtt cccaattgat ctcttggctc tgctgttctt gttgtagaga    780
 taatgccata agataatcct gatctatctg atcttgttgt cctttgtata cagtttcagg    840
 atctgaagga ggtcgaagat gaaattctga gtcacagaaa tttccatcac catctacgtt    900
 gtgtaggctt tcccaaacaa ctttctcttc agtaagaaac ccctggtccg ttaccaacaa    960
 atacagttga cccttgtatt tggtcatggt gctaaaatga ttattccgaa agaacacaca   1020
 aagttctcct tcctgaaccg ttgaagttag ttcacataat ccatg                   1065



      <210> 1917
      <211> 1065
      <212> DNA
      <213> Homo sapiens


      <400> 1917
 gaatccctat gttaaacccg tggtttctca tgaattagat cataatttaa cattgtaaaa     60
 tttcagaaac tattgtgcta atatttagat ttcaggaagg aatcagacta aatcaattac    120
 ctccattcat tgttagaaca gaagatataa tagcttacta actgatatga gttatgaatg    180
 tcactatgac acaaaatttg ctgtgatttg ctaatctggc tacaagtgca gtatttttca    240
 tgaatgacaa cacacagcat ttccaacttg taacatgaaa ctccagctca taaagagtgt    300
 attgtgtgac ttgaaaaagt ctgattgtaa ctaagtaaca accgttcccc tgaaaaaacg    360
 aacaaaatcc attaggaaat caggcacaga cggtattgat cggtttttct tcctttcctc    420
 ctgtggtttt gtttctcaag acatataggt ggttccaaca gaagccaaca cttgttacaa    480
 aataacacag ctattttttt ccttttcttt ttctttatct ttttctcgtg gttccttccg    540
 tttacgttca ctattcccag attgtcttcc acttgatgga gaggcttgtg ctggctggcc    600
 ctgctgagcc tgtgtagaag cagcagcagc agcagctgct gcttgttcct gttcctgata    660
 gtattgagaa gcccgtctgt cctcttcctc ttggagtttc tttgctagtt ccaaatcact    720
 gattccttcc gggatttgtt cccaattgat ctcttggctc tgctgttctt gttgtagaga    780
 taatgccata agataatcct gatctatctg atcttgttgt cctttgtata cagtttcagg    840
 atctgaagga ggtcgaagat gaaattctga gtcacagaaa tttccatcac catctacgtt    900
 gtgtaggctt tcccaaacaa ctttctcttc agtaagaaac ccctggtccg ttaccaacaa    960
 atacagttga cccttgtatt tggtcatggt gctaaaatga ttattccgaa agaacacaca   1020
 aagttctcct tcctgaaccg ttgaagttag ttcacataat ccatg                   1065



      <210> 1918
      <211> 1073
      <212> DNA
      <213> Homo sapiens


      <400> 1918
 actcgtacag agtcggcgaa ttctctctga agatcttcct atccttttct gggggaatgg     60
 ggtcgatgag agcaacctcc tatggttgtt gtgagaatta aatgagataa aagaggcctc    120
 aggcaggatc tggcatagag gaggtgatca gcaaatgttt gttgaaaagg tttgacaggt    180
 cagtcccttc ccacccctct tgcttgtctt acttgtctta tttattctcc aacagcactc    240
 caggcagccc ttgtccacgg gctctccttg catcagccaa gcttcttgaa aggcctgtct    300
 acacttgctg tcttccttcc tcacctccaa tttcctcttc aacccactgc ttcctgactc    360
 gctctactcc gtggaagcac gctcacaaag ggctaatctc gggccttgtc gaaggaagag    420
 gctgcagacg ttaatgaggt tagctgctgg attccagtat tcgtcgcata aggatccttc    480
 tttgtctgcg aaggaaaaac acactgatta tcataatgag gcacgtgggc cgtggcccgg    540
 ctgggtcggc tgaagaactg cggatggaag ctgcggaaga ggccctgatg gggcccacca    600
 tcccggaccc aagtcttctt cctggcgggc ctctcgtctc cttcctggtt tgggcggaag    660
 ccatcacctg gatgcctacg tgggaaggga cctcgaatgt gggaccccag cccctctcca    720
 gctcgaaatc cctccacagc cacggggaca ccctgcacct attcccacgg gacaggctgg    780
 acccagagac tctggacccg gggcctcccc ttgagtagag acccgccctc tgactgatgg    840
 acgccgctga cctggggtca gacccgtggg ctggacccct gcccaccccg caggaaccct    900
 gaggcctagg ggagctgttg agccttcagt gtctgcatgt gggaagtggg ctccttcacc    960
 tacctcacag ggctgttgtg aggggcgctg tgatgcggtt ccaaagcaca gggcttggcg   1020
 caccccactg tgctctcaat aaatgtgttt cctgtcttaa caaaaaaaaa aaa          1073



      <210> 1919
      <211> 2202
      <212> DNA
      <213> Homo sapiens


      <400> 1919
 tcaaaatgaa aattcagtgg acaagtgggg aaaaccttta gtgattgata aactcaagga     60
 aatggccaaa gtcgagggtc tctggaactt gtttttgcca gctgtcagcg gactcagcca    120
 cgtggactat gccttgattg ctgaagaaac aggaaaatgc ttttttgctc cagatgtctt    180
 taactgccaa gcaccagaca cagggaatat ggaggttctg cacctgtatg gaagtgagga    240
 acagaagaaa cagtggcttg agcctcttct tcaagggaac attacctctt gcttctgtat    300
 gacagaacct gatgtagctt caagtgatgc cacgaatatt gaatgcagca tccaacgaga    360
 tgaagatagc tatgtaatta acggcaaaaa atggtggagc agtggagctg ggaatcccaa    420
 gtgcaaaatt gcaattgttt tgggaagaac tcaaaatact tctctctcca ggtaattaaa    480
 caattctgat tgagaaacct gtgtaggaat gagccagtct tcctcctatc taggtaattt    540
 acttaaaatt cactgtttgg actcacaaat cataatgtaa gatatgagag taaatgtcat    600
 atatttgtat ttcacaagta ttttctaaca ggtgtttttg gaaaacatta tagggagtat    660
 tgctgaacat tcttcgctgt ggaattttca gtattagaaa gtgttgctaa attatcaaag    720
 ctgtttggat taaattatca gacaaatttt ttcagacctg tgtaatgaag tgattagatg    780
 tttagatcaa aggcaataat cttgaaatgt ttaattatat atataagttc ccagttacca    840
 ttgttgagca gtgagaagct tcaatcaaac aactcattta ttttcaaatc attgtttctg    900
 ttccagatca cagcctgcat cagactatgt tggtgtacgt cttttacaca gttcccattc    960
 cagtcatcac tgcttacatg actacatgaa aacatcaaaa agacaattgg gattctgctt   1020
 attatctgtt ttatttttct tcttagcaaa ctttttctaa tacaattttt cttttgacta   1080
 gacacaaaca gcacagcatg attcttgttc ccatgaacac acctggagta aaaataataa   1140
 ggcctttgtc agtttttggc tacacagata attttcatgg aggacatttt gagatccatt   1200
 ttaatcaagt gcgagttcct gccacaaatc taatactagg tgaaggtagg ggatttgaaa   1260
 tttcccaagg ccgccttgga cctggcagaa tccaccactg tatgagaaca gtaggtttgg   1320
 cggaacgcgc tttgcagatc atgtgtgagc gggcaacaca aaggatagct ttcaagaaga   1380
 agttgtatgc acatgaggtt gtggctcact ggattgctga aagccgcatt gccattgaga   1440
 agatccgctt gttgactctg aaagctgctc acagcatgga cactctgggc agtgctggcg   1500
 ctaagaaaga gattgcaatg atcaaagtgg ctgccccacg ggctgtcagc aaaatcgttg   1560
 actgggccat ccaggtgtgc ggaggtgctg gtgtttccca ggattaccct ctggctaaca   1620
 tgtatgctat aacccgagtt ttgcgtttag cagatggacc tgacgaagtt catctttcag   1680
 caatcgcaac aatggagctg cgggaccaag ccaaaagact gacagccaag atataaggag   1740
 ggtggcactg ccacatccca ctggcagaaa ctctccttta tacaaacttc attggctcca   1800
 acatttgaat ctcatatttt tgtagcagtt tgagcacagg gttaattatt catttgtggt   1860
 aaagattata gcatctattt tgatcagtgg gttttattat ttcaagggtc acacagggtt   1920
 aagttcagta agaaatgctg tagctgttgt cattcaatct agtgcctcct tgaggccagg   1980
 agttcaggac cagcctgggc aacatagcga gacccccatt gctacaaaaa atttaaaaat   2040
 gaaacaagtg tggtggcaca tgcttgtagt cctagctact tgggaggctg aggcaggagg   2100
 attgcttgag tctaggagtt tgaggttaca gtaagctgtg atcgtgacat ggcctccagc   2160
 ctgggtgacc gagtgagact gtttctaaaa ataaaaaaaa aa                      2202



      <210> 1920
      <211> 2202
      <212> DNA
      <213> Homo sapiens


      <400> 1920
 tcaaaatgaa aattcagtgg acaagtgggg aaaaccttta gtgattgata aactcaagga     60
 aatggccaaa gtcgagggtc tctggaactt gtttttgcca gctgtcagcg gactcagcca    120
 cgtggactat gccttgattg ctgaagaaac aggaaaatgc ttttttgctc cagatgtctt    180
 taactgccaa gcaccagaca cagggaatat ggaggttctg cacctgtatg gaagtgagga    240
 acagaagaaa cagtggcttg agcctcttct tcaagggaac attacctctt gcttctgtat    300
 gacagaacct gatgtagctt caagtgatgc cacgaatatt gaatgcagca tccaacgaga    360
 tgaagatagc tatgtaatta acggcaaaaa atggtggagc agtggagctg ggaatcccaa    420
 gtgcaaaatt gcaattgttt tgggaagaac tcaaaatact tctctctcca ggtaattaaa    480
 caattctgat tgagaaacct gtgtaggaat gagccagtct tcctcctatc taggtaattt    540
 acttaaaatt cactgtttgg actcacaaat cataatgtaa gatatgagag taaatgtcat    600
 atatttgtat ttcacaagta ttttctaaca ggtgtttttg gaaaacatta tagggagtat    660
 tgctgaacat tcttcgctgt ggaattttca gtattagaaa gtgttgctaa attatcaaag    720
 ctgtttggat taaattatca gacaaatttt ttcagacctg tgtaatgaag tgattagatg    780
 tttagatcaa aggcaataat cttgaaatgt ttaattatat atataagttc ccagttacca    840
 ttgttgagca gtgagaagct tcaatcaaac aactcattta ttttcaaatc attgtttctg    900
 ttccagatca cagcctgcat cagactatgt tggtgtacgt cttttacaca gttcccattc    960
 cagtcatcac tgcttacatg actacatgaa aacatcaaaa agacaattgg gattctgctt   1020
 attatctgtt ttatttttct tcttagcaaa ctttttctaa tacaattttt cttttgacta   1080
 gacacaaaca gcacagcatg attcttgttc ccatgaacac acctggagta aaaataataa   1140
 ggcctttgtc agtttttggc tacacagata attttcatgg aggacatttt gagatccatt   1200
 ttaatcaagt gcgagttcct gccacaaatc taatactagg tgaaggtagg ggatttgaaa   1260
 tttcccaagg ccgccttgga cctggcagaa tccaccactg tatgagaaca gtaggtttgg   1320
 cggaacgcgc tttgcagatc atgtgtgagc gggcaacaca aaggatagct ttcaagaaga   1380
 agttgtatgc acatgaggtt gtggctcact ggattgctga aagccgcatt gccattgaga   1440
 agatccgctt gttgactctg aaagctgctc acagcatgga cactctgggc agtgctggcg   1500
 ctaagaaaga gattgcaatg atcaaagtgg ctgccccacg ggctgtcagc aaaatcgttg   1560
 actgggccat ccaggtgtgc ggaggtgctg gtgtttccca ggattaccct ctggctaaca   1620
 tgtatgctat aacccgagtt ttgcgtttag cagatggacc tgacgaagtt catctttcag   1680
 caatcgcaac aatggagctg cgggaccaag ccaaaagact gacagccaag atataaggag   1740
 ggtggcactg ccacatccca ctggcagaaa ctctccttta tacaaacttc attggctcca   1800
 acatttgaat ctcatatttt tgtagcagtt tgagcacagg gttaattatt catttgtggt   1860
 aaagattata gcatctattt tgatcagtgg gttttattat ttcaagggtc acacagggtt   1920
 aagttcagta agaaatgctg tagctgttgt cattcaatct agtgcctcct tgaggccagg   1980
 agttcaggac cagcctgggc aacatagcga gacccccatt gctacaaaaa atttaaaaat   2040
 gaaacaagtg tggtggcaca tgcttgtagt cctagctact tgggaggctg aggcaggagg   2100
 attgcttgag tctaggagtt tgaggttaca gtaagctgtg atcgtgacat ggcctccagc   2160
 ctgggtgacc gagtgagact gtttctaaaa ataaaaaaaa aa                      2202



      <210> 1921
      <211> 550
      <212> DNA
      <213> Homo sapiens


      <400> 1921
 ctttggtgta ataaacttga tatgtactgg cttcctgctt atgtggtgca gttctactaa     60
 tagtatagct ttaacatgcc tatacttacc tgaccatttt tgatcttttt agtttaatga    120
 catgtttaat aagttactgg gtaacattga ggaaacctag ccctgtctat tcatttgggt    180
 ttgaaagatt agaagtcctg gctgtatttg cctccacagt cttggcacag ttgggagctc    240
 tctttatatt aaaagaaagt gcagaacgct ttttggaaca gcccgagata cacacgggaa    300
 gattattagt tggtactttt gtggctcttt gtttcaacct gttcacgatg ctttctattc    360
 ggaataaacc ttttgcttat gtctcagaag ctgctagtac gagctggctt caagagcatg    420
 ttgcagatct tagtcgaagc ttgtgtggaa ttattccggg acttagcagt atcttccttc    480
 cccgaatgaa tccatttgtt ttgattgatc ttgctggagc atttgctctt tgtattacat    540
 atatgctcat                                                           550



      <210> 1922
      <211> 6742
      <212> DNA
      <213> Homo sapiens


      <400> 1922
 cgcgcgccaa tgatgactaa ggctgtgccg gaggaacccc gaaagccagg aaggctgacc     60
 caggccctga actcacccct cacctgggag catgtttgga tttgcgtccc cggcggcact    120
 cctgactgtc tgacagacac cttcagagtg aagaggccac atctcaggcg ctctgccagc    180
 aacggtcatg tccctgggac tcctgtctac agagaaaaag aagatatgta tgacgagatt    240
 attgagttaa agaagtcatt gcacgtgcag aagagcgacg tggacctgat gagaacgaag    300
 ctccggcgcc tggaggagga aaacagcagg aaggaccggc agatagagca gctcctggat    360
 cccagccgcg gcacggattt tgttcggact ctggcagaga aaaggcccga tgccagttgg    420
 gtcattaacg ggctgaagca gaggatcctg aagctggaac agcagtgcaa ggagaaggac    480
 ggcaccatca gcaaactcca gaccgatatg aagactacca acctggaaga gatgcggatc    540
 gccatggaga catactacga ggaggtgcat cgtctccaga ccctcttggc aagttctgaa    600
 accaccggaa agaagcccct gggggagaag aagacgggcg ccaaaaggca gaagaagatg    660
 ggcagtgccc tcctgagctt gtcccggagt gtccaggagc tcacggaaga gaaccagagc    720
 ctgaaggagg acctggaccg cgtgctgagc acctccccaa ccatctccaa gacacagggt    780
 tatgtggagt ggagcaagcc ccggctgctg aggcgcattg tggagctgga gaagaaacta    840
 agtgtgatgg agagctcaaa atcacacgcc gcagagccag tcagatcaca cccgccagcc    900
 tgccttgcat ccagctctgc gctgcacaga cagccacgag gggaccgcaa caaggaccac    960
 gagcgtctcc gaggggctgt gagagacctg aaggaagagc ggaccgcgct gcaggagcag   1020
 ctgctgcaga gagatttgga ggtgaagcag ctcctgcagg cgaaggccga cctggagaag   1080
 gagctggagt gcgcgaggga gggcgaggag gagaggagag agcgagagga ggttttgaga   1140
 gaggagattc agacacttac cagcaagctc caagaattgc aagaaatgaa gaaagaagag   1200
 aaagaggatt gcccggaagt tcctcataag gcccaagagc tcccagctcc cactcccagc   1260
 agcaggcact gcgagcaaga ctggccgccg gattccagcg aggaggggct cccgcggccc   1320
 cgctccccct gctctgatgg gagaagagac gccgcggcca gagtcctgca ggcccagtgg   1380
 aaggtgtaca agcacaagaa aaaaaaggct gttctggatg aggcggctgt ggtgcttcag   1440
 gcagctttca ggggacatct cacgcggaca aagctcttag caagcaaagc acatggctca   1500
 gagccaccca gcgtgccagg cctcccagac cagagctctc ctgtgccccg cgttccgagc   1560
 cccatcgccc aggccacggg cagccctgtg caggaggagg ccatcgtcat catccagtcc   1620
 gctctgcggg cacacctggc ccgggccagg cacagtgcta ccggtaaaag aaccaccacc   1680
 gcagcttcta ccaggaggag atcggcttca gccacacacg gggacgcctc ctccccaccc   1740
 ttcctcgcag ctcttcctga cccctctccc tcagggccac aggccgtggc acctctacct   1800
 ggggatgacg tcaactccga tgattccgac gatattgtca ttgcaccgtc tctgcccacg   1860
 aagaactttc cagtttaggt ccccgtcact gtctccacgc tgtgatggca gcgctgccga   1920
 ggacatagga accacgactg gaaagataat ttatcgtgtt aggagaagaa cgatgatacc   1980
 tacttaacac ctcagcatct gcgtggtgtc tctttgtgct tttgtttgtg gaaggagacc   2040
 caaatgcctt tactttattc tctggggagg gccagcggct cgcatccccc tcatctccag   2100
 ctgcagctcg gatggtggat tttcagtgcc aacagacaca tctgccgtga actcgcagat   2160
 gccagggagc cctgtagtga cacgttctct gacagcacct tgccgcctgc ccacgacctt   2220
 gaccgtgagg agctgctata cgcaaccagc gccgacacca tgccccctct tcctggtgac   2280
 accctcaaca accaggattt gctcgatctc agcccagcag gccaggcaga cacaccccgc   2340
 tgtgccttag gaaggtgtga gaccggcttc ccccatcccc acagcaaaac acggcctgtc   2400
 ccaagccagt gaggagctaa agacacccag gtccccaaat gatcttactc catgccccac   2460
 ccgctcacac cgtcctttcc cgtcaccctt gctatcccct ggagcactgc cctccagagc   2520
 tgcccttccc aggaaggaat ttggttggat tctgtcactg tggagaccaa gattttttaa   2580
 aattcccaat tacaaaagca gcatcacact tgcttctgag aacagcaggg tgatgtctgt   2640
 tcccaagctg gtggcgggag ccttagcctg tgtggggcca cccggggaag aggaggagag   2700
 gagggtgagg aggcaggctc gccgttccaa gggacagcat aggctcgtgg tggggcgtgt   2760
 tgcatctggt gtctgggaca gtccccgtca ccccatgtgt gcggcctctg cactcccaag   2820
 ctccatggct gggctgggct gggctgggct gggctgggcc gggcgtgcgg agcctgtgga   2880
 gccagcagct gcagaggcct aggagggagt tcctggggga agcgcacagt gtccagtgcc   2940
 catctcttgc ttgtgtgtga gattagccct tgctggggcg tcaagaggaa gagccttaga   3000
 cctgggcggg ccttcagggg catctagacc cctgcacagc ccaggcctgg tgtctgcatt   3060
 tccacagcac ccctgtgggg actcctgccg gggctggccg ctgtctcagg agagacccaa   3120
 tggttagaaa gccccttttt acacagctga cagcttctcc caaggcttcc gtccacgggg   3180
 acaggcttaa cccctgggcg ccttttctgc agcatggcgg ccttctgagt cacctaagct   3240
 gagcctgggt cattctctgt ggcggtcaga aggccgatgg ccccaacaca gtggcttgtg   3300
 aaagggagag aggaggctct gcatgtccac ctgctctatg ggaggaggac acaggtgtcc   3360
 ccagcccagc ctgttctctc ccagtcactc agggatgggg ccacccaaag tgcaggaccc   3420
 gccccaccct gcggttcgaa gcctggcccc tgtctccact tagcttctgt ttctgcagtg   3480
 ggtggaagcg agtcagcggg gggcctggct tgtgtacgtg ttttccttat ttggtctgtg   3540
 ggttgccaag tccatttttt tttccactga actggctggt aacttgatgg actgtgtaac   3600
 tgacacaggc cctctttaga cccctgcctt caccccaccc gcccgggtcc actccctggg   3660
 gcgctgtccc aagccatccc tgcttgccag ctcaaagctt caggtcctag gagccagtcc   3720
 acctcgaaag ccctgagaaa gtgagacacc tgcacattcg ctgggggaga ccctccgttc   3780
 tcttgtggca gctgctccca cttgttaaac caagctgttt ctgcgggacg tgctcactct   3840
 tgggaaccag tggcctagag ctttgggtta caggcatgga gagggctttc ctgcctcagg   3900
 cttggaggcc aatgttccat acataaaccg ccatgtcctc tggtgcagct gggctgctct   3960
 tttaaaagcc agcatccatc ttgaagctcg ctgggtaaat ggcaatgcat tctcaagcca   4020
 gtgtcttcag ctgatgccca gtgtccagtg ctggtcacca gtcccctttg ctgggtacag   4080
 cctgcctggc tgttctgtgg tcctggaacg ctgcagtgtg gttttgttcc atggagacag   4140
 taccaagcgg agaggcctcc ttgcccacgg ccccagggcc tgggggccag gggttctggc   4200
 cctgcgggga cttaggcagg aggggaagag aagcccatgg agccatggga ggggtgagct   4260
 gtgggcgggg cctagtcatg ggaggggtga gctgtgggcg gggcgagctg tgggtggggc   4320
 ctagccatgg gagaggtgag ctgtgaatgg ggctagctat gggtggggtg agctgtggac   4380
 agggcctagc catgggaaag gtgagctgtg ggcggggcct agtcacggga gaggtgagct   4440
 gtgggcgggg cctagtcatg ggaggggtga gctgtggatg gggcctagcc atgggagggg   4500
 tgagctgtga gtggggctga gccatgggag cagcaagctg gtggagtggg ctgggcggag   4560
 ctgtgggggc tgctggcagg gcctaggaaa gtagacaact cccgggggag acgaagtaga   4620
 gagtgagtcc ccaagaaagg gactcctgcc ccagcgtcaa gtgccaaagc aggccccatc   4680
 taccacttca gggtcgacgt tggtggcagg tgttgttcac ggtgtactga ttgtcactgc   4740
 aacacctcca catcaccttg aacttcaaga acagcagcaa agctgtatct gctatcagag   4800
 gctgttaggt agtccagctt taaaataaca cactctttct ctatcccatg ccctttaaac   4860
 aagcagccac aggagatgtc agtctccagg gcctggcccc actgtgttga cagcagtcat   4920
 gtctgttgag ctgacactgc tgaggctgaa gctggccctg tgcaggtggc tggtgagcca   4980
 caggtgcagt acccggaggt gtgctctccc ctagaggcct gtccccaact cctcccctag   5040
 aggcctattc ccgctgctca cagacctcag cagaggcacc agctggaggg ctccagggac   5100
 atccttggaa atacaggagg ctttcctggc acagggcaca gctcttagga ggcctttgta   5160
 ggacgctgtc tccccagcgt gtcctgctca tccaggatgg ggagaaagag gaggaggccc   5220
 caggctcaga agccagggac agactgccga cgattaccaa actgaatcca ggcagtgcca   5280
 tgaccctggg tgtcccttgg ttcacatcac ccaccagaca gctgcggaga gagtgcaggg   5340
 aggggctggg accaaacagg ccagaaacca gcagaaaaga ggcagaagtg aggtgggtgt   5400
 gcctggggca cgaagccagc gccgggggga tttcagtgga gccttacagc caggctccgt   5460
 gcggactgtg atgccagaga ggcgtgcagc ctctgggcaa gtcgggagag ggcttgggtg   5520
 gtccccacaa ggcagaagag gtggaagggc cagagaagac caccaagacc accgttcccg   5580
 caggcctggg gtgagtgacc tgactgagac tagcgggcag agccaagcag ggctaaactc   5640
 caacccaggg cccggtgttg gacaaagtag ctttttcttt gctcgtttgt ctgtgtatta   5700
 agaagagact aaaatagcca aacgacgctg gtcgcatgcg ctggctgtgg tctgtctgct   5760
 gaatgtctat ttttgtctcc tgacgagacg tgaggaccat gcccttgatc cctccgatgg   5820
 accagaaacc cccttccttg caaaaaaaag gcaattgaat taggaaaaga tagaccaacc   5880
 tagctcagat ccaccaagat aagcacagca aagcttggct gcatttttga ggaataaaaa   5940
 cctgcagaaa gcaccgataa ccttcaagat ctgaatgaga ttctattata acccgtctaa   6000
 accgattgca aaattcctcc tttggttttg gaaaacaacg ttgcttctcc cgtggctcgg   6060
 attctctgag gaccagggag ttgacacaca aaccccgcca tgggtccgag ccagctattt   6120
 ctcaaggctc ccacctcgcc aagctcccaa gggcctgctg gcagtgccta cgctgtgcca   6180
 actaccctgt ctggtacaga ccacggctgg gtaagcaccc ttaaaagcaa cagaaatgac   6240
 gtctggaagc tgaaatgtga aactgtcaag atggcttaag gagaggaagg agtggacccg   6300
 ctggtctttg gcattttgta tttagaatta ttctaacttt atacataatg tataggccga   6360
 tcttttggaa gggataaggt tttcattctt gtgcaactca ttattctcat tattggcctt   6420
 ttaaataaaa agttgttttg cagtgtgcct tgagtgcccc gtgaaaactt ctctttaatg   6480
 acctccaggt gtgttcctgc cccacgcact cgggctgaac aaacgatccg cttcaaaaac   6540
 cccgcttctc tgggcttctg gcattttgcc gtggtcgtaa tgcaggcttg gggttggaga   6600
 gccagctgga gggacgggtc ccgccgccag ctccctgcca cgcatgaact cggatacatc   6660
 tgttgacacc ccggtccccc gtcaaatatc tattccctct gcctgttgag tatgggtgta   6720
 tccacggttc cgtccccaac ac                                            6742



      <210> 1923
      <211> 5618
      <212> DNA
      <213> Homo sapiens


      <400> 1923
 tttttttttt ttcataaaga aagaaacggc aatgcaattt aaaaactggt aggccgttta     60
 aaagagccgg tttgacctct gacaaaccca gccaagacaa ggccccttgg cccggctcgc    120
 gagtctttgt agagagcaga gcttaccctg acgacgatgg cgttttgtgg ttaaagtgac    180
 ttgggcgcac ccccaggaca gggtctggtc ccacacgttc acaccagggg ggcgggaggg    240
 gggacatcaa aaacagacca catcctctgc cagacgggct ccagggagta gcggtttgga    300
 cgagggacat ttacaaagca cagagtgcac aaataagttt tggttaattt accaaattac    360
 acagcagtcc ttcaagtttt tcaagtttca taaaaaggag gaggggagga gaaaggggga    420
 aaaaaacaaa aacaaaaaca aaccgacgaa ccaaacaaaa agaaaaagaa aaaccaaaca    480
 ctgaagaaaa ataataaacc agattaacaa cacaactgta tcgctccaaa gacggacaga    540
 gaagttgaca ggttcacaca cggtttgcgg tatgtacatc aatttacaga ggttgcgacg    600
 caggggagag aggttcacac tcgtgttttc gctttgttag aggcgctcgg ccacacccag    660
 cacccatgtg tgcccagcgc acacgtgcac acgcacccca cgcacggcca cacgcgcacc    720
 cacgctcgct tgcacacacg cccacacgca cagacacgcc tgcgggcagc aggcgcaggg    780
 gagcgcgtat caccagtccg cgtcctcctc tatgtaataa tcaggggcgg taccatcaaa    840
 gaggccgggg tcgagggact tccgctgctt ccctctggcg aagacgcggg agatggagcc    900
 gaatcccatc ttctctttct tctttttccg tttttggtct tcaagatcct ctagtgactg    960
 tacaataggg ttgtgcaggt tcttctgaac tgggccggga ctgtcgccct gtagccagag   1020
 gagaagagga agatgaaaca gcagagacag gtgacacagg agagcagagg cggcccgtgc   1080
 ggtgtggggc cttccgtgga aggatgccat ctctcagggg ccaccctgcc tctgcagtgg   1140
 ggagcccacc ccccatctcc tgaagcagat acccccagat ggcttattga tggggcctgg   1200
 agtttcccta gagttcctgg ggtcctctcc tgcccagtct ggcctctcaa cccccagcat   1260
 cttctgacca acaaattagc cactccaggg cgtctaagtt cctgtcccag tctgtcctct   1320
 gagttagagc tagagcttgg ttagacttgg tgctttccat aaagaaatgt acttttatag   1380
 aaaaagcaca aaatagagaa ttttgggaca gaaacaaact tgggagacca cgtagcctct   1440
 agcttccccc acaaccgaca caatgaatct cttagtttgc gcaggggcag gcaggactcg   1500
 ttagccctat tcacagatat caagagaggc agcagacagt ccactaccgt ggagctaatt   1560
 ggatgcagag ctacagctcc aattgggggc tgtcagattc ctcctggcac agtgctcctt   1620
 ccaggcagga gctccagggt aactgcatac ttggtcctga gctttgggct gccccaggag   1680
 gggtctgaac tccttccctt tttcctaggg agcctcagac gacaggtccc taggatgggc   1740
 aggtaggaca tttccattgt gttgccagcc ctgccttacg tgggtgtgga gggaaccctt   1800
 aatagcctac aggtgtacaa aagccttcac tacatcccag aatcagtctg ccctgtctgg   1860
 agcccacaga tcctttggat caaaacagtc attactaggg agactcctgg tggttatttc   1920
 tggaattgca agcataatgc caaggtccgt caaccttctc caacctctct atgctgagtt   1980
 cctacttttg ctctaaatta gtggccagag tgtgagagga tgaggcagtc attagtccag   2040
 gctgcactat tcttgctggt ggacgtcaga tgcccaaggc aaagggttac ctgtagctat   2100
 ttttgggctc ttcctggctt acctgcatgc acacctgttg agatgggggg ataaaaaggg   2160
 ttgaggaagt gagggaatta atgaatggta gtttagtctt tagtctcaag gtttgcaaac   2220
 agaatccatt ctgaaggcag ctaagatagt tccactctgg ataggaacat ctttgccaaa   2280
 tctatgggta aagagaatgg ggcctgctca ctgaaacgcc tgtatgcaga caactggctt   2340
 atcaaagcac ccatttcctg gcagcaggaa tgtgccaagg ctatggtggg caaaagacta   2400
 gggctgggtc aaatgcaatt caagaggcct ttggagaact ccttctgcag aatggggttt   2460
 ttccagcagc atttctgctg ccagagtccc catgggccca ccacgagaag acaaaatatg   2520
 gccgtggggg gaaggtattc tcaactggga tgagaatggt gcagggacac tgctggctgt   2580
 aggtataact ccacagtggt ccttcaggat cagggaatgg atgtcagaga cccctccagt   2640
 ggcccacctt ccttgccttg gttctgttag tcaagataga ctttgtcact aggattctct   2700
 tctggggaca agagaagaac atactgcttc ctcaaagcac cagtataaaa cagagaatcc   2760
 cgccaggtgc agtggctcat gtctataatc ccagcacttt gggagactga ggtgggcaga   2820
 tcgcctgagg tcaggagttg aagaccagcc tggccaacat ggtgaaatct catctctact   2880
 aaaaatacaa aaattagccg ggtgtgatgg caggcatctg taatgccagc tgctcgggag   2940
 gctgaggcag gagaattgtt tgagcctgga aggtgttggt tgcagtgagc tgagactgcg   3000
 tcactgcact ccatcctggg tgacaagagt gaaactccat cacacacaca tacaaataaa   3060
 taaaataaaa caataaaaaa gagaatccca ggcctgagca gggccccagg ctgcaaatga   3120
 ccttcctact ctgaggaggc catctaaagt ccccgggcca gcaatctctg ccgcccacct   3180
 gagcagactg aggcagcttc tctgaagttt actcttagct atttttataa gcacttttca   3240
 ttattgtgga ttgaaaaaaa tggttccata attacgactc atctatagga aagtgattga   3300
 tttttacaca ctgatttcca agcaacactg ttatgtacat gcttattatt cattctaata   3360
 gcttttcaag ttattctctt gagttctcca ggtagagaat catgtcactg gcaagtaatg   3420
 gttttgtcca atgtgttcac ctcatttctt ttttattatc tatttcgctg gttaataaag   3480
 tgacattaac tgagttttgg aaaaagccgt ctcgtgcatt tgaggatcta accctatgat   3540
 gtctgtcttc aggatatggc agaggggagc ctctgcatta ccaactgtgt gataaaacaa   3600
 aaattcaagg tggtccccac acccagaccc caatatttca tgttagagcc tcgacatggc   3660
 ttccaactgt cctcagaagc tcaacccacc ttcaatttac tcccacactg ttgcagagcc   3720
 catctgtctg ccccactagt catcaagagc taggcagcta gggcctttgc ctcctgggag   3780
 ctggtgccca gtatgcaatc aaaaagtgtt tgatgaaata aacaaaggaa acaaacttag   3840
 accatattca caagcctctc cagaggcaat tcatgccaag actcctgggt caggatagag   3900
 agctggctct aaagggaaat gaggaggtgc tggggaggcc ctgagctctg gaaggtaatg   3960
 tgtgggagga gaagcccacg gtcccagaca gggcccactg gggcagagtt ccaggctgtg   4020
 cctgcggccg acccaggccc gcttcctctg gattctcctc accctcccgg acacaaggag   4080
 caaacgggcc tcattccttt ttctccccac atccatcgct tcttgcaaaa ggaaagaaca   4140
 gaacaggaaa tgcattcgcc agagtgctcc ctgggtggac gagaggaaac agcgagtatg   4200
 gcttcacccc gccacccccg cccctgcagt ttctgggcag ggcccagggg cccaggcccc   4260
 gctgctgctg gccttacgtt gcagagggag tgtgtccggt gtcgagggga gttgatgtcg   4320
 ctcggtgtgg acgaccggtc gccttcggcg gcagatgcgt cggagatgac agagggctgc   4380
 cgggagtggc aggggctcac cctgaccgct tgccggtccg cagggtgagg ggggtgtgag   4440
 tggtagagag tctgttgact ctgccggatg gctgcggtca gcgggaggtc cgcctgcacc   4500
 acccactcct ggttgccatt gagcaccgtc tcgcccggca tggcgaggga atgccgcttg   4560
 gggacgtcct tggtcagcgt agctaaggac tgtttggcca tggccagctc ggcctccagc   4620
 tccttcatcc ggttgtcctt gaggtccagc tgggagcgca gtgccgtggc gtggtctgtg   4680
 gcctccttgg cttggcgccg cagctcccac ttctcacgct ccagcaggtc cttctccttg   4740
 gccagcgctt tgaccgcatc ctcgctctcc ttgcggtgct gctcatagtt gcggatgaag   4800
 tctcggagct gctcctcgcg gctctccagt gtggcataca gctgctgcat ctggctcacc   4860
 aggtctgtct tctcgccctt taagcgcttc cgatcagctt tcatggcctg caaggcttct   4920
 ttggctctgg ctagctcctg ctccttctgg gccagctgga ccctgagctc ggtggccgag   4980
 aggacctcag aggacttgcc gccctgcgac tcctccaggt ccttcgccaa catctccttc   5040
 atctgccgga gaaggtgaac ttcctcctgg agccgcgaca cttcttcccg caggagcact   5100
 tgcgctccaa gctgggggtt ctccatgttc gtcgccgccg agtcccccgc cgccgaggcg   5160
 ctggccgcgg ctcccgggcc cgggccgggg ccgccgccgc cgctcagttc cgccagtctc   5220
 cggttggtgg ccgtgagttc ggctcgcagg ttggtcacct cctggctggc cgactggacc   5280
 gccccatcga tgcggagcgc gagctgctta ttgtcttcca tcatgctcag gattttggcc   5340
 tgggggcgag agaggtgaca aagagctgca tgatgcgcgg ggggcgcgcg gccgggcacc   5400
 cccggctcta cctgttgtgt cctccgcggc ccggcttcgc ccgcgccccg acccccaggc   5460
 accggcagcg ccggttcctc cggcacagga atgacagcgg cgcctccagc cctagccgcg   5520
 gcggtggcga ggcggcgggg ggaggaggcg gaggagaaaa aagaggagga gaaggaggag   5580
 gaggagcagc gatcgccgag accccggcgg gcgggcgc                           5618



      <210> 1924
      <211> 1139
      <212> DNA
      <213> Homo sapiens


      <400> 1924
 tgccactgtg aaggagatga tgagagcccc ctgatcaccc cctgccactg cacaggaagc     60
 ctccacttcg tgcaccaggc ctgcctgcag cagtggatca agagctccga cacgcgctgc    120
 tgcgagctct gcaagtatga gttcatcatg gagaccaagc tgaagccact gagaaaatgg    180
 gagaagttgc agatgacgtc cagcgagcgc aggaagatca tgtgctcagt gacattccac    240
 gtcattgcca tcacatgtgt ggtctggtcc ttgtatgtgc tcattgaccg tactgctgag    300
 gagatcaagc aggggcaggc aacaggaatc ctagaatggc ccttttggac taaattggtg    360
 gttgtggcca tcggcttcac cggaggactt ctttttatgt atgttcagtg taaagtgtat    420
 gtgcaattgt ggaagagact caaggcctat aatagagtga tctatgttca aaactgtcca    480
 gaaacaagca aaaagaatat ttttgaaaaa tctccactaa cagagcccaa ctttgaaaat    540
 aaacatggat atggaatctg tcattccgac acaaactctt cttgttgcac agagcctgaa    600
 gacactggag cagaaatcat tcacgtctga ttgtgtgcgg gttgtcattt tcctggacat    660
 ccatgaagag ctgaaggaaa ttgtttactg ccaattgtat acctttctta tgtcctttaa    720
 tagcatagac tggacaggtg actatttata gtggcttctc tttttctaaa ccctccttag    780
 tctcctagaa aaccttcctg tgggccaggc atgcctgggt cctgcctctg cctggcagct    840
 ctgtgggaaa gtggaagacc ccatgatgac atcatgggga gccagcagag ttcctgccca    900
 tggtcttgag ctgaatgaga gaataaaatg ccaatcccaa gggaagagga ggagcagggg    960
 tgcccaggcc ctgataccca gccgcctcca gcttgcagtg gtccccagcc tggagcagag   1020
 cattggggag tgtctaagcc atgacgagaa gattccctct gcatcacggc gaacccccag   1080
 gagatggtat ttgaaaacag acccccaaac acagactcct gcctgccctc ttgccgatg    1139



      <210> 1925
      <211> 1077
      <212> DNA
      <213> Homo sapiens


      <400> 1925
 aatacactgc tcactataat tgtactgttc ccagatccgc catccctctc aagcaactca     60
 tctatcaggt cctccagctc attctcaacc tgcatctctt gtgaactgag cacctcaggc    120
 tgcccagcaa tcaccactga gtcggtttca gcctccccat ccatgatatc cccatctgcc    180
 acctctgtct gagtgacatc atgatcctcc tcctgcactt ctgcttcccc aggctcgcct    240
 gggtcctgct ggttgctact ggaatcttga gaggctcctt gggcatcctg ctcagacttg    300
 ttcttgctag aagcactctt gctgccaaaa aggctactgg gctggttcac aatccgggaa    360
 agtgtttcca aaggcttcag agcagcattg actgtgttgg ccatgttggg actggacagg    420
 tctaagctgt gaggtactct ggccaggtca ttaaccagtc ccttcttcag gaaaagccga    480
 atgatgttgt tcatgccatt gtgctgggtc ttcgctgtgg cactgctgta gaagctggag    540
 gtggaggggc aggactccat gatagtactg atgatacaca tcactgcctg aagcctggca    600
 tgtttctctg tactctcagc catagccagt gcccgtccaa gggctgcttt tacttcattc    660
 actagggcca cctgggcatc tgtgccactc cctgcagcag ccaggcttgc gaggaacagg    720
 cgggccaagg caggggtgtc cttgtcttct gcattctggg tatgtgggag caggtggtcc    780
 agaacaaaag ctagcacact gcagtcctct ttgatcagtt cagactggcc cacagtgtag    840
 ctgtagttgg caatcagggt agcaatacca acataggacc tcaccaactc tgccagaaga    900
 cgaaggatag tggaggtagg cattaaaggt ttgctgccct tgcctttctg tttgccttcc    960
 tcagaggccc ggtccccttc tttatctttc ttcccatctc gagactcctc tggagttgaa   1020
 gcctctcctt gggagatccc agatgcggaa gtctcagtgg aggcacccac gcgtccg      1077



      <210> 1926
      <211> 1404
      <212> DNA
      <213> Homo sapiens


      <400> 1926
 cggcgggcgg tggctttggg gccgaagtgg gcgtgcggct cgcgctgttc gcggccttcc     60
 tggtgacgga gctgctcccc ccgttccaga gactcatcca gccggaggag atgtggctct    120
 accggaaccc ctacgtggag gcggagtatt tccccaccaa gccgatgttt gttattgcat    180
 ttctctctcc actgtctctg atcttcctgg ccaaatttct caagaaggca gacacaagag    240
 acagcagaca agcctgcctg gctgccagcc ttgccctggc tctgaatggc gtctttacca    300
 acacaataaa actgatcgta gggaggccac gcccagattt cttctaccgc tgcttccctg    360
 atgggctagc ccattctgac ttgatgtgta caggggataa ggacgtggtg aatgagggcc    420
 gaaagagctt ccccagtgga cattcttcct ttgcatttgc tggtctggcc tttgcgtcct    480
 tctacctggc agggaagtta cactgcttca caccacaagg ccgtgggaaa tcttggaggt    540
 tctgtgcctt tctgtcacct ctactttttg cagctgtgat tgcactgtcc cgcacatgtg    600
 actacaagca tcactggcaa ggacccttta aatggtgaaa atgggcagat gaatagcaat    660
 aagtggacct ttgttactct tctgagttag aaaaattcta atttagtaca ctctgaacaa    720
 agcttattat acttacttaa gatgtgtttt gatttggtgt tcagaaagca acctgacaat    780
 gataatactg taactatgat aaaattgaga ataaaaagat tttatttaga aatcataagt    840
 ctggaattga ggttatttta gccccacagt agagtatcct ggagggccag gtcctctatg    900
 ctatgtgtat gtaataggat ttaggagcct aatattaaga gaagaccttg tttccactct    960
 cttcagatgt actagttgga tccatgattg gaatgacatt tgcctatgtc tgctatcggc   1020
 agtattatcc tcctctgact gatgcagaat gccataaacc atttcaagac aaacttgtac   1080
 tttccactgc acagaagcct ggggattctt attgttttga tatttaaaaa ttgaatctgg   1140
 ccgggcgtgg tggctcatgc ctgtaatccc aacactttgg gaggctgagg agggtggatc   1200
 acctgaggtc aggaccagcc tggccaacat ggggaaccct gtctctacta aaaatacaaa   1260
 aattagccag gagttgtgtg ccgtaatccc agctacctgg gaggctgagg taggagaatt   1320
 gcttgaacct gggagctgga ggttccagtg agccgagatc gcaccactgc actccagcct   1380
 aggcaacaga gtgagacccc gtct                                          1404



      <210> 1927
      <211> 1404
      <212> DNA
      <213> Homo sapiens


      <400> 1927
 cggcgggcgg tggctttggg gccgaagtgg gcgtgcggct cgcgctgttc gcggccttcc     60
 tggtgacgga gctgctcccc ccgttccaga gactcatcca gccggaggag atgtggctct    120
 accggaaccc ctacgtggag gcggagtatt tccccaccaa gccgatgttt gttattgcat    180
 ttctctctcc actgtctctg atcttcctgg ccaaatttct caagaaggca gacacaagag    240
 acagcagaca agcctgcctg gctgccagcc ttgccctggc tctgaatggc gtctttacca    300
 acacaataaa actgatcgta gggaggccac gcccagattt cttctaccgc tgcttccctg    360
 atgggctagc ccattctgac ttgatgtgta caggggataa ggacgtggtg aatgagggcc    420
 gaaagagctt ccccagtgga cattcttcct ttgcatttgc tggtctggcc tttgcgtcct    480
 tctacctggc agggaagtta cactgcttca caccacaagg ccgtgggaaa tcttggaggt    540
 tctgtgcctt tctgtcacct ctactttttg cagctgtgat tgcactgtcc cgcacatgtg    600
 actacaagca tcactggcaa ggacccttta aatggtgaaa atgggcagat gaatagcaat    660
 aagtggacct ttgttactct tctgagttag aaaaattcta atttagtaca ctctgaacaa    720
 agcttattat acttacttaa gatgtgtttt gatttggtgt tcagaaagca acctgacaat    780
 gataatactg taactatgat aaaattgaga ataaaaagat tttatttaga aatcataagt    840
 ctggaattga ggttatttta gccccacagt agagtatcct ggagggccag gtcctctatg    900
 ctatgtgtat gtaataggat ttaggagcct aatattaaga gaagaccttg tttccactct    960
 cttcagatgt actagttgga tccatgattg gaatgacatt tgcctatgtc tgctatcggc   1020
 agtattatcc tcctctgact gatgcagaat gccataaacc atttcaagac aaacttgtac   1080
 tttccactgc acagaagcct ggggattctt attgttttga tatttaaaaa ttgaatctgg   1140
 ccgggcgtgg tggctcatgc ctgtaatccc aacactttgg gaggctgagg agggtggatc   1200
 acctgaggtc aggaccagcc tggccaacat ggggaaccct gtctctacta aaaatacaaa   1260
 aattagccag gagttgtgtg ccgtaatccc agctacctgg gaggctgagg taggagaatt   1320
 gcttgaacct gggagctgga ggttccagtg agccgagatc gcaccactgc actccagcct   1380
 aggcaacaga gtgagacccc gtct                                          1404



      <210> 1928
      <211> 1231
      <212> DNA
      <213> Homo sapiens


      <400> 1928
 aaaaggaagc acagaagcct ttatttctgg tacggctggg tgggggactg gtctcctccc     60
 gtcctctgcc gggctgcctg ggggttgggg gcctgctggt gggtgggccg gcactgacag    120
 gagagggccg cgtgccaggc ccatcccaca gaaaagccct ccttggccat ggtcgggaga    180
 tgcagccaaa ggacagtcag gcttcctccc ggtggcggcg tgggctgggc agggaaggct    240
 tcccggagga ggcatcattg tccactgaga agcaccgtgg ggcctggcca ctgcctgtgt    300
 gtctgcttgg agctgggcac ggctgggccc ttcaaactct gctgcagccg tgggaggaca    360
 gcagggtgag gggtgtggca gggtgggggg catggtgggg cagggaaggt gctgggggga    420
 ccacaggcgg gacgtgcagg ggcccactgg gtcactggta ctggttgggg gaggacagcg    480
 tgttgcagcg gctgtgcgac atgtcctcgt acaccacaca tgccgccgaa ttcttatccc    540
 gccacgagca cagtttcttt atctgtgtcc tcgccagcac acacgccacc cccaggccca    600
 gcccgaggag gaaggagatc accgccaggg ccgcagggag ggcagaggct gctggcgggt    660
 cagggagggc agaggctgtc tgcgggtcag ggagggcgga gcctgtcggt ggggcaggga    720
 gggcagaggc ccttggtggg gcgtccgagc atctgtgcca tccttgggac tgttcctctg    780
 tcaccaggac cagggtgccg gagccgtaga cattgacctc cgtgatggcc tggcaggtgt    840
 aggtgccagt gtccgacagc tgcaggcggt gcatggtgat agtcaggttg tcctgggacc    900
 ctgagaagtc gatgcggccc cggaaccgtc tgtccgtagt gggcaccacc ccgtcctcgt    960
 agtaaatgat gtcttggggc tgtggcccga gctgcctcag gtagatccca cgcaggcccc   1020
 cgctggtgga gcaggtgatg ttgacggagg ctcccacggg gacagtcgtg cagtggggag   1080
 actgctgcac ctcttgggca gccagggccc caggcaggcc gcgagccagc gccagaagca   1140
 ggggcagcag caggagcctc ggaggcccgg ccatgttccc cacacccagc tctcccagcc   1200
 gggcgagtgc agctgagcct ctctgggtct a                                  1231



      <210> 1929
      <211> 856
      <212> DNA
      <213> Homo sapiens


      <400> 1929
 cccacgcgtc cgacttttta cagtaatcac ttattttttt gtggtaattg gcattgcccc     60
 aatttttatc ctttatgaat tggattcacc actctgctgg aatgaagttt ttataggtta    120
 tggatcagct ttgggtagtg cctctttttt gactagtttc ctaggaatat ggcttttttc    180
 ttattgtatg gaagatattc atatggcctt cattgggatt tttaccacga tgacaggaat    240
 ggctatgacc gcgtttgcca gtacaacact gatgatgttt ttagccaggg tgccgttcct    300
 tttcactatt gtgccattct ctgttctacg gtccatgttg tcaaaagtgg ttcgttcgac    360
 tgaacaaggt accctgtttg cttgtattgc tttcttagaa acacttggag gagtcactgc    420
 agtttctact tttaatggaa tttactcagc cactgttgct tggtaccctg gcttcacttt    480
 cctgctgtct gctggtctgt tactacttcc agccatcagt ctatgtgttg tcaagtgtac    540
 cagctggaat gagggaagct atgaacttct tatacaagaa gaatccagtg aagatgcttc    600
 agacagagcc tgttaagctg ctattgatag tcggagctta tatactgtga cttctgaaga    660
 ctatacatga attccccaat cagtgctttg ttgatacaaa atccttaaaa gggaggcact    720
 ttaaagaata tgtatttttc acttttctta atatgtttca tcggtgacag gcatgataat    780
 atttctatat gtaatgggta attgggaaaa aatagatgat aaataaaatt gctctaaaga    840
 agttaaaaaa aaaaaa                                                    856



      <210> 1930
      <211> 856
      <212> DNA
      <213> Homo sapiens


      <400> 1930
 cccacgcgtc cgacttttta cagtaatcac ttattttttt gtggtaattg gcattgcccc     60
 aatttttatc ctttatgaat tggattcacc actctgctgg aatgaagttt ttataggtta    120
 tggatcagct ttgggtagtg cctctttttt gactagtttc ctaggaatat ggcttttttc    180
 ttattgtatg gaagatattc atatggcctt cattgggatt tttaccacga tgacaggaat    240
 ggctatgacc gcgtttgcca gtacaacact gatgatgttt ttagccaggg tgccgttcct    300
 tttcactatt gtgccattct ctgttctacg gtccatgttg tcaaaagtgg ttcgttcgac    360
 tgaacaaggt accctgtttg cttgtattgc tttcttagaa acacttggag gagtcactgc    420
 agtttctact tttaatggaa tttactcagc cactgttgct tggtaccctg gcttcacttt    480
 cctgctgtct gctggtctgt tactacttcc agccatcagt ctatgtgttg tcaagtgtac    540
 cagctggaat gagggaagct atgaacttct tatacaagaa gaatccagtg aagatgcttc    600
 agacagagcc tgttaagctg ctattgatag tcggagctta tatactgtga cttctgaaga    660
 ctatacatga attccccaat cagtgctttg ttgatacaaa atccttaaaa gggaggcact    720
 ttaaagaata tgtatttttc acttttctta atatgtttca tcggtgacag gcatgataat    780
 atttctatat gtaatgggta attgggaaaa aatagatgat aaataaaatt gctctaaaga    840
 agttaaaaaa aaaaaa                                                    856



      <210> 1931
      <211> 1820
      <212> DNA
      <213> Homo sapiens


      <400> 1931
 tttttttttt ttagggataa tgcttttata ttagtttttc tataacaaga aaaatcagct     60
 ttgagatttt tatcattttt ttccttagaa aagaataaaa aataaaggca cccggaactt    120
 cccccacagg cctgaagaac aaaggtgtct cctaggtgca gctgggtcct tcctccctgg    180
 ctcagcccag ccccatcacc tctgcttcac tcctgcccca aggccccagc agcacccagg    240
 gggctctccc atcctgcctc cactgggctt gcccattgga aaagtgcctg tgtcctgcca    300
 gggcgtggca gggagggact cttagcagag tgactgccca gcacctggag gagcagggtg    360
 ggccaggcca ggccagcagt cctgaaggct cctgtcccca taggatggga aaggaataaa    420
 agccagcttt tgtgagttcc agagggtggc aggcacctgg ccacagagca tggataccct    480
 tgtgtcttct ccagggaacg gacggacaga tggacagggc agacggcgag ctgctatggc    540
 tgattctggc tggggcaaga gctgtctgtg gcataggctt tggagggctg ttcgcacatg    600
 acttgtgcat gtgtgtgtgt gtggtgtgta tgcatacgca tacacatgtc agcaggggga    660
 gggaatgggt gcctgtgtgt gccagggcag gggcagaccc ttccctgcat gattcagagg    720
 gcgtggcagc ggtagtgggg gtgtgacaga gactgtggtg gtttggaggg tagttgtgtg    780
 tggctgagct gggtgtttga gggtgtgatg tgtgtgcatg tgtctggccg tgggacacgc    840
 cgtgggaagg ggtggggata tgagactgtg tcagcccgtg tcatgtggga tgcctcatgt    900
 gtgcagctgg gtgtgtctgt gtgagcacgg cagagtgggg ggctcacagc acacaggcgt    960
 gtgctgcaga aaagagtccg gcggtccatc atcctaggtc acatctgcat caccttgtca   1020
 ctatcttgtt tcctcttcct caacctcatc ctcttcctcc tcctcctttt ccttccccaa   1080
 gcggccacgg tccttggaaa tgtcaccaaa ctctaagttg ccttcaatgt ccaagacctg   1140
 caggtgcttc agcctccgga aggcactgtc caccacggag cccacagcca gcttgttaaa   1200
 cctgagaaag atccccttga ggttgggcgt ggagtcgaag gcattggcgg gcaccgcact   1260
 aatcttgttg ttctgcaggt acaggtactc aagtgactcg gggagcccct cggggatctc   1320
 tgtgagctga ttcccggcga tgtccagcag ctgcagatgg gcgaggtcca cccaggcacg   1380
 ggggcccagg gctcggctgc gcagtcggtt gctggtgagg tacagctcac gcagctgagc   1440
 catgcccgcc agcgcccctc gtgccaaggc agccagctca ttgcgcttga ccttcagcac   1500
 atggacattt cgaggcagcc caggtggcag catgtgcagc cggttgcccg acaggtccag   1560
 cgagcgcagc aggcgcagct tgcggaaggc gtcgcggtgc acctgtgggc tggtgatgcg   1620
 gttgtagctg aggttgagct cctccaggaa gtaggtggtg gcaaagtctt cgcggccaat   1680
 gcctgtgatc tggttgtgca ggatcatgaa ggcgcgcacg cggcgaggca ggccactggg   1740
 cacgcgctac agcgcgttat agtacaggtg cgccgtgtgc aaccgcttga ggccctggaa   1800
 ggcccggacg agtgggtcgg                                               1820



      <210> 1932
      <211> 1697
      <212> DNA
      <213> Homo sapiens


      <400> 1932
 cctggcggat ggagacatgc tgcccctgct gctgctgccc ctgctgtggg gggggtccct     60
 gcaggagaag ccagtgtacg agctgcaagt gcagaagtcg gtgacggtgc aggagggcct    120
 gtgcgtcctt gtgccctgct ccttctctta cccctggaga tcctggtatt cctctccccc    180
 actctacgtc tactggttcc gggacgggga gatcccatac tacgctgagg ttgtggccac    240
 aaacaaccca gacagaagag tgaagccaga gacccagggc cgattccgcc tccttgggga    300
 tgtccagaag aagaactgct ccctgagcat cggagatgcc agaatggagg acacgggaag    360
 ctatttcttc cgcgtggaga gaggaaggga tgtaaaatat agctaccaac agaataagct    420
 gaacttggag gtgacagccc tgatagagaa acccgacatc cactttctgg agcctctgga    480
 gtccggccgc cccacaaggc tgagctgcag ccttccagga tcctgtgaag cgggaccacc    540
 tctcacattc tcctggacgg ggaatgccct cagccccctg gaccccgaga ccacccgctc    600
 ctcggagctc accctcaccc ccaggcccga ggaccatggc accaacctca cctgtcagat    660
 gaaacgccaa ggagctcagg tgaccacgga gagaactgtc cagctcaatg tctcctatgc    720
 tccacagacc atcaccatct tcaggaacgg catagcccta gagatcctgc aaaacacctc    780
 ataccttccg gtcctggagg gccaggctct gcggctgctc tgtgatgctc ccagcaaccc    840
 ccctgcacac ctgagctggt tccagggctc ccctgccctg aacgccaccc ccatctccaa    900
 taccgggatc ttggagcttc gtcgagtaag gtctgcagaa gaaggaggct tcacctgccg    960
 cgctcagcac ccgctgggct ccctgcaaat ttttctgaat ctctcagttt actccctccc   1020
 acagttgctg ggcccctcct gctcctggga ggctgagggt ctgcactgca gatgctcctt   1080
 tcgagcccgg ccggccccct ccctgtgctg gcggcttgag gagaagccgc tggaggggaa   1140
 cagcagccag ggctcattca aggtcaactc cagctcagct gggccctggg ccaacagctc   1200
 cctgatcctc cacggggggc tcagctccga cctcaaagtc agctgcaagg cctggaacat   1260
 ctatgggtcc cagagcggct ctgtcctgct gctgcaaggg agatcgaacc tcgggacagg   1320
 agtggttcct gcagcccttg gtggtgctgg tgtcatggcc ctgctctgta tctgtctgtg   1380
 cctcatcttc tttttaatag tgaaagcccg caggaagcaa gcagctggga gaccagagaa   1440
 aatggatgat gaagacccca ttatgggtac catcacctcg ggttccagga agaagccctg   1500
 gccagacagc cccggagatc aagcatctcc tcctggggat gcccctccct tggaagaaca   1560
 aaaggagctc cattatgcct cccttagttt ttctgagatg aagtcgaggg agcctaagga   1620
 ccaggaggcc ccaagcacca cggagtactc ggagatcaag acaagcaagt gaggatttgc   1680
 ccagagttca gtcctgg                                                  1697



      <210> 1933
      <211> 1697
      <212> DNA
      <213> Homo sapiens


      <400> 1933
 cctggcggat ggagacatgc tgcccctgct gctgctgccc ctgctgtggg gggggtccct     60
 gcaggagaag ccagtgtacg agctgcaagt gcagaagtcg gtgacggtgc aggagggcct    120
 gtgcgtcctt gtgccctgct ccttctctta cccctggaga tcctggtatt cctctccccc    180
 actctacgtc tactggttcc gggacgggga gatcccatac tacgctgagg ttgtggccac    240
 aaacaaccca gacagaagag tgaagccaga gacccagggc cgattccgcc tccttgggga    300
 tgtccagaag aagaactgct ccctgagcat cggagatgcc agaatggagg acacgggaag    360
 ctatttcttc cgcgtggaga gaggaaggga tgtaaaatat agctaccaac agaataagct    420
 gaacttggag gtgacagccc tgatagagaa acccgacatc cactttctgg agcctctgga    480
 gtccggccgc cccacaaggc tgagctgcag ccttccagga tcctgtgaag cgggaccacc    540
 tctcacattc tcctggacgg ggaatgccct cagccccctg gaccccgaga ccacccgctc    600
 ctcggagctc accctcaccc ccaggcccga ggaccatggc accaacctca cctgtcagat    660
 gaaacgccaa ggagctcagg tgaccacgga gagaactgtc cagctcaatg tctcctatgc    720
 tccacagacc atcaccatct tcaggaacgg catagcccta gagatcctgc aaaacacctc    780
 ataccttccg gtcctggagg gccaggctct gcggctgctc tgtgatgctc ccagcaaccc    840
 ccctgcacac ctgagctggt tccagggctc ccctgccctg aacgccaccc ccatctccaa    900
 taccgggatc ttggagcttc gtcgagtaag gtctgcagaa gaaggaggct tcacctgccg    960
 cgctcagcac ccgctgggct ccctgcaaat ttttctgaat ctctcagttt actccctccc   1020
 acagttgctg ggcccctcct gctcctggga ggctgagggt ctgcactgca gatgctcctt   1080
 tcgagcccgg ccggccccct ccctgtgctg gcggcttgag gagaagccgc tggaggggaa   1140
 cagcagccag ggctcattca aggtcaactc cagctcagct gggccctggg ccaacagctc   1200
 cctgatcctc cacggggggc tcagctccga cctcaaagtc agctgcaagg cctggaacat   1260
 ctatgggtcc cagagcggct ctgtcctgct gctgcaaggg agatcgaacc tcgggacagg   1320
 agtggttcct gcagcccttg gtggtgctgg tgtcatggcc ctgctctgta tctgtctgtg   1380
 cctcatcttc tttttaatag tgaaagcccg caggaagcaa gcagctggga gaccagagaa   1440
 aatggatgat gaagacccca ttatgggtac catcacctcg ggttccagga agaagccctg   1500
 gccagacagc cccggagatc aagcatctcc tcctggggat gcccctccct tggaagaaca   1560
 aaaggagctc cattatgcct cccttagttt ttctgagatg aagtcgaggg agcctaagga   1620
 ccaggaggcc ccaagcacca cggagtactc ggagatcaag acaagcaagt gaggatttgc   1680
 ccagagttca gtcctgg                                                  1697



      <210> 1934
      <211> 861
      <212> DNA
      <213> Homo sapiens


      <400> 1934
 tcccgggtcg acgatttcgt ctggagtgtt agcaccagta ctggatgtga cagcaggcag     60
 aggagcactt agcagcttat tcagtgtccg attctgattc cggcaaggat ccaagcatgg    120
 aatgctgccg tcgggcaact cctggcacac tgctcctctt tctggctttc ctgctcctga    180
 gttccaggac cgcacgctcc gaggaggacc gggacggcct atgggatgcc tggggcccat    240
 ggagtgaatg ctcacgcacc tgcgggggag gggcctccta ctctctgagg cgctgcctga    300
 gcagcaagag ctgtgaagga agaaatatcc gatacagaac atgcagtaat gtggactgcc    360
 caccagaagc aggtgatttc cgagctcagc aatgctcagc tcataatgat gtcaagcacc    420
 atggccagtt ttatgaatgg cttcctgtgt ctaatgaccc tgacaaccca tgttcactca    480
 agtgccaagc caaaggaaca accctggttg ttgaactagc acctaaggtc ttagatggta    540
 cgcgttgcta tacagaatct ttggatatgt gcatcagtgg tttatgccaa gtaagtgctg    600
 atttgttctc attcaacttg tccagagggt ttcaatgtct ttgtgtaaat ggtttacata    660
 gtctcactct ctgaatcact catctttaca ctttttagag tttgtaaatg gtgaaagatt    720
 tgaaaattaa ggtatgattt cagtgaaaag taccaagtgt tgtattgtgc gaaggaaaag    780
 tagactagag ttatttttct ttccttgagt gtcacttgaa tataaaagaa taaaaatttt    840
 tgaatagtgt taaaaaaaaa a                                              861



      <210> 1935
      <211> 879
      <212> DNA
      <213> Homo sapiens


      <400> 1935
 ggcacgacca gcctctgtcg gaggcgaatt ctcagagtga gggttccctg tcacttgaga     60
 gaaggttccc tgtgacgtga ccttggggga cgtcattgcc ctttctgtcc ccacccaccc    120
 cctcggcagt tctgttggcc aggactttgg cctagacaaa ggatgggggt tgtggctgtg    180
 gagcggaagt gggtctcaac cactataaag cctctctgtg cccgtccgga gctggtgagg    240
 acagcctgcc agagtctggt ctctggacac tatgggcaca cgactcctcc cagctctgtt    300
 tcttgtcctc ctggtattgg gatttgaggt ccaggggacc caacagcccc agcaagatga    360
 gatgcctagc ccgaccttcc tcacccaggt gaaggaatct ctctccagtt actgggagtc    420
 agcaaagaca gccgcccaga acctgtacga gaagacatac ctgcccgctg tagatgagaa    480
 actcagggac ttgtacagca aaagcacagc agccatgagc acttacacag gcatttttac    540
 tgaccaagtt ctttctgtgc tgaagggaga ggagtaacag ccagaccccc catcagtgga    600
 caaggggaga gtcccctact cccctgatcc cccaggttca gactgagctc ccccttccca    660
 gtagctcttg catcctcctc ccaactctag cctgaattct tttcaataaa aaatacaatt    720
 caagttgctt ctcatggatg gcactgcttt tctgaggact caaggtgcca agatggaggg    780
 gctgactcag tccagccaac atttaatgag cacctacttt atgtatggag ctctaaccca    840
 tgggtccatg ggaataaagc agtgaatagt aacaataaa                           879



      <210> 1936
      <211> 879
      <212> DNA
      <213> Homo sapiens


      <400> 1936
 ggcacgacca gcctctgtcg gaggcgaatt ctcagagtga gggttccctg tcacttgaga     60
 gaaggttccc tgtgacgtga ccttggggga cgtcattgcc ctttctgtcc ccacccaccc    120
 cctcggcagt tctgttggcc aggactttgg cctagacaaa ggatgggggt tgtggctgtg    180
 gagcggaagt gggtctcaac cactataaag cctctctgtg cccgtccgga gctggtgagg    240
 acagcctgcc agagtctggt ctctggacac tatgggcaca cgactcctcc cagctctgtt    300
 tcttgtcctc ctggtattgg gatttgaggt ccaggggacc caacagcccc agcaagatga    360
 gatgcctagc ccgaccttcc tcacccaggt gaaggaatct ctctccagtt actgggagtc    420
 agcaaagaca gccgcccaga acctgtacga gaagacatac ctgcccgctg tagatgagaa    480
 actcagggac ttgtacagca aaagcacagc agccatgagc acttacacag gcatttttac    540
 tgaccaagtt ctttctgtgc tgaagggaga ggagtaacag ccagaccccc catcagtgga    600
 caaggggaga gtcccctact cccctgatcc cccaggttca gactgagctc ccccttccca    660
 gtagctcttg catcctcctc ccaactctag cctgaattct tttcaataaa aaatacaatt    720
 caagttgctt ctcatggatg gcactgcttt tctgaggact caaggtgcca agatggaggg    780
 gctgactcag tccagccaac atttaatgag cacctacttt atgtatggag ctctaaccca    840
 tgggtccatg ggaataaagc agtgaatagt aacaataaa                           879



      <210> 1937
      <211> 798
      <212> DNA
      <213> Homo sapiens


      <400> 1937
 tttttttttt aaaagctatg ttgttagcac acagaacact tcattgttgt ttttggggga     60
 aggggcatat gtcactaata gaatgtctcc aaagctggat tgatgtggag aaaacacctt    120
 tcccttctag ttttgagaga cttcctcttg gctcccagga ggagggattc cctgactttg    180
 acacacatgg ccaccttggc acaaaagcct tgtggtatag aaaaacaaat ttgtttttat    240
 gtcctcttct ccctttccat ctttcagcat agacttaact cccttaagcc cagacatctg    300
 ttgagacctg acccctagtc attggttacc agtgtgtcag gcaatctgga ctttccagtg    360
 atgccactga gatggcacct gtcaaaagag cagtggttcc atttctagat tgtggatctt    420
 cagataaatt ctgccatttt catttcactt cctgaaagtc agggtcggct tgtgaaaagt    480
 tgttaaacaa catgctaaat gtgaaatgtc aaccctcact ctaaactttc cctgttcaga    540
 gcatcagatg aagacttcat tgggttttat agtggctttc tgatttttgg tagtccattg    600
 aagaagggag tttgaaagtt gttgtatact gttaacgatt gtctgcccat gtcctgcctg    660
 aaataccatg attgtttatg gaaagtatct ttaataaagc tggatacagt ttgaaaaaaa    720
 aacgcggccg cgtcgacttt ggtttttgga gatggttttc tcgatggggg ctgggagggt    780
 ataatgtcga cgcggccg                                                  798



      <210> 1938
      <211> 2375
      <212> DNA
      <213> Homo sapiens


      <400> 1938
 atggtctcga tctccgacct cgtgatctgc ccgcctcggc atcccaaagt gctgggatta     60
 caggggcccc caggcctgga ctccatctca gacccttcag ctggagctgg attcctggac    120
 tggggagaga tcgggatgcc tggtcccggg agagctggcc accaagccct ctgcaagtgt    180
 gactgccagt gtctggagaa aacaaccacg aaggccccag ggaaaatgcc taagagtact    240
 agaagtgggc ctgtccgggt tcgtctggcc gatgggccca accgctgtgc tggccggctg    300
 gaatgtggca tgccggacgc tggggaacag tgtgtgatga caactgggac ctcgggacgc    360
 cactgtggcc tgctgggaac tgggctgtgg aaaggctaca cagacttgac gattatcccc    420
 cctggacctg ggaccccacc tcaagagagg acctgccaag gggactacca cagcgggggt    480
 acctggacac actctcccct ggagaccacc cggcgcccgg gtagctcctc cccagcaata    540
 aggcgcctgc cggcacagat gctgctgctg cctgcgcggc caccccaccc tcggtcctcc    600
 tctccggagg ccatggaccc accgcccccc aaggctcccc ctttccccaa ggcggaaggc    660
 ccctcctcca ctccttcctc ggcggcgggg ccccgacccc cgcggctggg ccgccacctc    720
 ctcatcgacg ccaatgggtg tacccctaca catacacggt gcagctggag gaggagcccc    780
 ggggcccgcc ccagcgcgag gcgcccccag gagagcccgg ccctcgcaag ggctacagct    840
 gcccggagtg cgcccgtgtc tttgccagcc ctctgcggct gcagagccac cgcgtgtcgc    900
 actcggacct caagcccttc acgtgcggcg cctgcggcaa ggccttcaag cgctccagcc    960
 acctgtcgcg gcatcgcgcc acgcaccgcg cccgcgccgg gccgccgcac acctgcccgc   1020
 tctgcccacg ccgcttccag gacgccgcgg agctggcgca gcactcctgg ggcacaccca   1080
 gaggtcccct tctcgccgcc gcctgcaact gcgaggtagc ccggggccgc ttggagtcgc   1140
 ccggacctga gaggctgctg cacgggtacg ggggccggga ggaggaaggg ggctgggggc   1200
 gggcggcggg agggctggac cgcgtggagg gcttcatctc ctccaaggcc caccactacc   1260
 tgcttattga cactcagggt gtcccctaca cagtgctggt gacgaggagt cacagaggga   1320
 gccaggggcc agtggggctc caggccagaa aagtgctaca gctgccccgt gtgctcaagg   1380
 gtcttcgagt acatgtccac cttcagcgac acagcatcac ccactcggag gtaccacagg   1440
 actttgcagg gagcctggac tccttccaga cacctggtga gagcctgagg ctggtgttca   1500
 gggccctgga cacgacacag agcagccgca tctcaaaggc agagccctgc ctgaaggagg   1560
 aaccgttatc acttggagac ttaccatata tgcacacgac cctctgcttc tgccgcaaac   1620
 ggcgggcctc acctggaccc gggactcttc aacgaggggc gctagcctgg cccgactggg   1680
 cgagtccccg cgccctgccc gttccgtcgc tcagttccac gacacgctcc cctgccgccc   1740
 ccctgttcgc ggttccgctc agtggacgaa ctacccaggc tatggccttt gatggcatca   1800
 tcttccaggg ccagtcacaa agatccgcag gcctcacgac taccagccgc ttcctggcat   1860
 gtcagagacc cctccgtcta tgtgcctggt gggcctcccg cagcccgcgg tgcacgttgc   1920
 gccgcccagt tggcctccgc cctggagtac atccacgccc gcgcctggtg taccgggacc   1980
 tgaagccgga gaacgtcatg gcgtcgggcc agccccggga ccgccctcag ccctggttcg   2040
 cctggccgcc gcggccgacg cgcttctgcg ggggctgctg gaccctcacc ccgaaggagg   2100
 agcgctgtga tcgccatcag ggagcacctg gggcgccctg gaggcagcgg gagggcgagg   2160
 cggaggcagt gggagcggtg gaagagaggc tgggcagtga ggaggccccg ggggatgcag   2220
 aaagggaagc cgcccacccg aggcccccaa ggccaacggc ttttggtgtc tcctcgggcc   2280
 tcccagaact gctggtgaag cgggtggtgg cccagttgca ggagctctgg acttcctcca   2340
 cagccggggg ctggtccacg cagatgcaaa cctga                              2375



      <210> 1939
      <211> 958
      <212> DNA
      <213> Homo sapiens


      <400> 1939
 tgcctgtatg tctgaggctg ggtttgaagc ctccagcgtg tttggagtta atccccatta     60
 ggttggactc cgcccctttc tcccaaaggt aaagcaaggt tttcaggcat cactgcaaag    120
 ggcagctagt attcccatcc ttgtctaaca agctgtaagg agaagttgtt tctgagatct    180
 gagcctgaag agagggaaca agtcagtcag ccttcgtggt cagaagagaa acctgtgacc    240
 atgaggagca gcctgaccat ggtgggaacc ctctgggcct tcctgtccct tgttactgct    300
 gtgaccagtt ctaccagtta cttcctacct tactggctct ttggatccca gatggggaag    360
 ccagtgtcat tcagcacatt ccggaggtgc aactaccctg tgcggggaga gggacacagt    420
 ctgatcatgg tggaagaatg tgggcgctat gccagcttca atgccatccc aagcctggcc    480
 tggcagatgt gcacagtggt gacaggtgcc ggctgtgctc tgctgctcct ggtggcacta    540
 gctgctgtcc tgggttgctg catggaggag ctcatctcca gaatgatggg acgttgcatg    600
 ggagcagcgc agtttgttgg agggctgctg ataagctcag gctgtgcctt atacccttta    660
 ggatggaata gcccggagat aatgcaaaca tgtgggaatg tctccaatca atttcagtta    720
 ggtacctgtc ggcttggctg ggcctattac tgtgctggag gtggagcagc tgcagccatg    780
 ttgatctgca cctggctctc ttgctttgct ggaagaaacc ccaagcctgt catattgggg    840
 gggaagcacc atgaggaaaa ccacttctta tgctatggag cttggccatt gccctcaacc    900
 cttgagcttc gaaaagaaga ccgggggggg cgggcaacag ggaagcaagt gacccccc      958



      <210> 1940
      <211> 2817
      <212> DNA
      <213> Homo sapiens


      <400> 1940
 aaatgttcca gctgatgatg tgtctggaaa taaacatgaa actatttata caatactaaa     60
 tcaggacgcc cagaacaaga gtcccagcgc ggtcatgagc cacgaatcgg atgctgctca    120
 ctctgacagt gccaggtcat cttccagcaa gttagaactc tcgcctgatg ttaacaaaat    180
 aaggaaatca gagcccaaga tcaagaagtc tgtaagtcat gaaagagtct ccaaaatgaa    240
 tttttaattg actggaaaag ggatcacctt tttctcatct gagagcaaga aatatgagag    300
 acccaaggat gatcgagagg aagagttcaa cacgtgggtc aataatatgt acgtcttctt    360
 tgtgaacacg ctctttcatg cgtataaacg tgaagaagct atcaaggaga aaataagggc    420
 agacaggtta cgtagcacag cacaggccca gcagcggaag atggaagatg acgaactgga    480
 agcaaggctg gacatcttta tcttgagaga ggaagaggcc aagagacatg actatgaggt    540
 ggacatcaca gtgctcaagg agccggcaga cgtgtcatcc tctcacctca tactggaccc    600
 tcccaaggag gatgtgaccg tgtccccatc cagcaagacc atcaccagca agaagaagaa    660
 aaagtagaga gacacgagga cacacacaca ggcttaggat ggcacgtgct gtaagatttc    720
 ctgagcatta cagttcttag cactgaactc gtcacagtgt tttaacatac cccttggccc    780
 actgcatctc aggtttccta catggctgga ttacgggagt tcgagaccag cctgggcaac    840
 atagtgagac ccccccatct ctgcaaaatt aaaacatcag ccgaccgtgg tggtgtgtac    900
 atgtggttct agcttcttgg gaggctgagg tgggaggatt gcttgagctc aggaggttga    960
 ggctgcagtg agccattgca ttccagcctg ggtcacggag ctggtggcca gtgtaatcta   1020
 taaataggca gcaggagaga gactcaacac caaaccagaa ttttaaaaac ttttaacaat   1080
 ttattagtct tattttccag taaaatattc acagagatgt caaaagaatg agatggtgag   1140
 cgatatagcc aactaccttt aattaattcc acataaatag ttaagatcta aaaacctcag   1200
 atgagcagac cgagtcgaaa tgtgattctt caaagcaagt attgctttac ccttgtcctg   1260
 aatgcagtct gtcatatgac cactaatttg catgtgacca aatggttgca gagtgttttt   1320
 tagatatgct ctcggtgagc cgtcatccgt caatccaaga agaagatgtt gttgaactgc   1380
 gttgcacaaa gtttcttgac ctcttcattt acttcaatca ggtttgcatt tttttgattc   1440
 aaaataacat agagctcccg ccgatcagac ttctttccaa caacccagta atcactcatg   1500
 gccttcacaa tgatctcctc atcttcatcc actctggtaa agtcactgtt gatgtcaccg   1560
 agaatcttca ttaaatccgg gtgcacggaa gtgagcgaca cgctgggcgt tttcctcatg   1620
 tgaactgtgc tcttctcggc gagattcatg tggttgaagt agataaactt aaactggggt   1680
 tcctttcctc agaccccgga acatccccct tgttgatgtt aaaactgttc cacaagatgt   1740
 ccagaggccc agccactgtg aagctggggc cccaacgatg ctgtcccagt ccttcggcaa   1800
 aaaacccaac gttgggtgga cagaggcgtc gatcataaag cacacagccg cactcatggc   1860
 cttataaacg gattaaatgg agctcttcat aagtgtcatc tgtatttaca aaaattttgg   1920
 ggaatctgca ttttgcatct ggatcattga ggttcaaggg tccggtaaga aatcttccat   1980
 agtgttgaag atttcctggc atttctgctc ttattggaga atcccttcct gctaactcag   2040
 gttcggatgt gccttgggaa aagggaggtg gtaaggtatt tgtataaaat tctcatgtca   2100
 tcttgttcta atccactcca gatgagctga tcgttataga gaaaagcagt gtatttgact   2160
 atattcaggc tttcctccat tcgtattaat aaaggactgg attttcaaat aagtcatttt   2220
 atccaacggg aagaagctga ttccaccaaa aatgtcaagt aggtcacatg actgcaaatg   2280
 tagcgtttgc aaataccgat ggaagaattt ctctaatctt tctttcagaa gcttgacgcc   2340
 tccgtcttcc atggctttca gaaatgtacc attaaaaagc ttgtacatgc tgtagcactg   2400
 ccgcagcacc gagctataaa ccttgtccaa caactcctcc tcttgatatt caataactgg   2460
 ttttccatct ttactctgtt tttcaattat aggattccga acaaccatga ccatccagaa   2520
 attttcttct ggttcattga agaactgtct gttcttctgt gtatgtaaag attttgcagg   2580
 ttttgatggg ctaaatgtcc ttgtaaactg tacaatagct tcacacaatc cgacatttct   2640
 aatcttctca ttcttttcta cctcatttgg atgataaaat aaaatcttat tttcctcctg   2700
 tccttcgcgc ggcccgaagc gcgggttgta gatgaagaaa ctcagcagcg ccggcgggaa   2760
 ctgcttctcc tgggccgccc agggcccgct cccggccccg gccgccgctg cagccat      2817



      <210> 1941
      <211> 702
      <212> DNA
      <213> Homo sapiens


      <400> 1941
 aaagcaggtg cctggaaaag cctgctgagg gtgaagggga accatccagt gtcctgggtt     60
 ggggaagcat tttcctcttt atgagtctgt ctctggtcct catggaacaa aagtgggcag    120
 tggtggtatg agaagcagag gctaattgtc taccccctgc ctccaagtag aattactcct    180
 tgtctgtgta cctggtgagg cagttgactg caggaaccct tctacaaaaa ctcagagcaa    240
 agggtatccg gaacccagac cactcgcggg cactgagtga gtaacatctt tcctctcttc    300
 cccacctgat ctggattcaa gtcttcctgg ccctccagcc ttcataatta aacccatacc    360
 tcttttttga caacttactc cccttctcac atgaacccca accctccccc tctacccctg    420
 accagtcttc cagtctttat agttgaagtt ggaccactcc caggcaccct tgaatttcca    480
 atcatgtatc tgctttgcac ctcacagtcc ctaactccag ccctgctaga atatgggctc    540
 tccggactgg aaagaatctt aggggtcctc taatctaacc ctcacatgat gcttcaactc    600
 ctccagatca tctctaacat agccagagtg tcacgctatg tttaagcatc ttcagggatg    660
 ggaaaatccc ccacacccat gtattgcggc cgctctagag ga                       702



      <210> 1942
      <211> 1188
      <212> DNA
      <213> Homo sapiens


      <400> 1942
 attcccgggt cgacgatttc gtcacaatgc ccgccggggc ttcttcttct cccatattgg     60
 gtggctgttt gttcgcaagc atcgagatgt tattgagaag gggagaaagc ttgacgtcac    120
 tgacctgctt gctgatcctg tggtccggat ccagagaaag tactataaga tctccgtggt    180
 gctcatgtgc tttgtggtcc ccacgctggt gccctggtac atctggggag agagtctgtg    240
 gaattcctac ttcttggcct ctattctccg ctataccatc tcactcaaca tcagctggct    300
 ggtcaacagc gccgcccaca tgtatggaaa ccggccctat gacaagcaca tcagccctcg    360
 gcagaaccca ctcgtcgctc tgggtgccat tggtgaaggc ttccataatt accatcacac    420
 ctttcccttt gactactctg cgagtgaatt tggcttaaat tttaacccaa ccacctggtt    480
 cattgatttc atgtgctggc tggggctggc cactgaccgc aaacgggcaa ccaagccgat    540
 gatcgaggcc cggaaggcca ggactggaga cagcagtgct tgaacttgga acagccatcc    600
 cacatgtctg ccgttgcaac ctcggttcat ggctttggtt acaatagctc tcttgtacat    660
 tggatcgtgg gagggggcag agggtgggga aggaacgagt caatgtggtt tgggaatgtt    720
 tttgtttatc tcaaaataat gttgaaatac aattatcaat gaaaaaactt tcgttttttt    780
 ttttgtttgt tttgtttttg agacagagtc tcactctgtc acccaggctg gagtgcagtg    840
 gcgcagtctc ggctcactgc agcctccacc tacctggttc aagcaattct cctgcctcag    900
 cctcctgagt agctgagatt acaggagcct gccaccacac ccagctaatt tttttgtatt    960
 tttagtagag acagggtttc atcatgttgg ccagactggc ctcgaattcc tgacctcagg   1020
 caatccaccc gcctcggcct cccaaagagc tgggattaca ggcgtgagcc accgcaccct   1080
 gccgaaaaaa actttttttt ttttgagacg gaggctcgct ctgtccccca ggctggagtg   1140
 cagtggcgag atctcagctc actgcaagct ccgcctcccg ggttcacg                1188



      <210> 1943
      <211> 1794
      <212> DNA
      <213> Homo sapiens


      <400> 1943
 atgacctcgg gtcctcagac cagccagccc aaggaacatc tcaccaattt caaatcggat     60
 gaacaggaaa gagtttcttc tctagcccaa tctcacactg acaaccaccg gcttcatgag    120
 ccaggcctcc aggaaggcat tagagcagtt ccccgagaag atccccaatg gaactatcag    180
 gcagattccc ccagaggccc cctggaccat catagacgcc gagcttcagg taactcacag    240
 tggaggcaag ccaaactcat tgccttaact cgggccctca ctcttgcaaa gggactacgc    300
 atcaatattt atactgactc taaatatgcc ttccgtatcc tgcaccacca tgctgttata    360
 tgggctgaaa gaggtttcct ccctacgcaa gggtcctcca tcattaatgc cactttaata    420
 aaaactcttc tcaaggccgc tttacttcca aaggaagctg gagtcattca ctgcaagggc    480
 catcaaaagg catcagatcc catcactcag ggcaacgctt atgctgataa gcctattggt    540
 tttggattgg aaaagttatt gacatttcat ctctcccaat tgcaagaata tagaggaacc    600
 aagtggaggg aaaaatccca caggaaagtc aaccatgatg agaacacaag caaattgact    660
 tctttaaatg aagagtatac caaaaataaa acagaatatg aagaagccca ggatgccatt    720
 gttaaagaaa ttgtcaatat ttcttcaggc tatgtagaac caatgcagac actcaatgat    780
 gtgttagctc agctagatgc tgttgtcagc tttgctcacg tgtcaaatgg agcacctgtt    840
 ccatatgtac gaccagccat tttggagaaa ggacaaggaa gaattatatt aaaagcatcc    900
 aggcatgctt gtgttgaagt tcaagatgaa attgcattta ttcctaatga cgtatacttt    960
 gaaaaagata aacagatgtt ccacatcatt actggcccca atatgggagg taaatcaaca   1020
 tatattcgac aaactggggt gatagtactc atggcccaaa ttgggtgttt tgtgccatgt   1080
 gagtcagcag aagtgtccat tgtggactgc atcttagccc gagtaggggc tggtgacagt   1140
 caattgaaag gagtctccac gttcatggct gaaatgttgg aaactgcttc tatcctcagg   1200
 tctgcaacca aagattcatt aataatcata gatgaattgg gaagaggaac ttctacctac   1260
 gatggatttg ggttagcatg ggctatatca gaatacattg caacaaagat tggtgctttt   1320
 tgcatgtttg caacccattt tcatgaactt actgccttgg ccaatcagat accaactgtt   1380
 aataatctac atgtcacagc actcaccact gaagagacct taactatgct ttatcaggtg   1440
 aagaaaggtg tctgtgatca aagttttggg attcatgttg cagagcttgc taatttccct   1500
 aagcatgtaa tagagtgtgc taaacagaaa gccctggaac ttgaggagtt tcagtatatt   1560
 ggagaatcgc aaggatatga tatcatggaa ccagcagcaa agaagtgcta tctggaaaga   1620
 gagcaaggtg aaaaaattat tcaggagttc ctgtccaagg tgaaacaaat gccctttact   1680
 gaaatgtcag aagaaaacat cacaataaag ttaaaacagc taaaagctga agtaatagca   1740
 aagaataata gctttgtaaa tgaaatcatt tcacgaataa aagttactac gtga         1794



      <210> 1944
      <211> 639
      <212> DNA
      <213> Homo sapiens


      <400> 1944
 gctggcactg ctcgatttgt gtgtcaggca gaaggaatcc cctctcccaa gatgtcatgg     60
 ttgaaaaatg gaaggaagat acattcgaat ggtagaatta aaatgtacaa cagtaaattg    120
 gtaattaacc agattattcc tgaagatgat gctatttatc agtgcatggc tgagaatagc    180
 caaggatcta ttttatctag agccagactg actgtagtga tgtcagaaga cagacccagt    240
 gctccctata atgtacatgc tgaaaccatg tcaagctcag ccattctttt agcctgggag    300
 aggccacttt ataattcaga caaagtcatt gcctattctg tacactacat gaaagcagaa    360
 ggtttaaata atgaagagta tcaagtagtc atcggaaatg acacaactca ttatattatt    420
 gatgacttag agcctgccag caattatact ttctacattg tagcatatat gccaatggga    480
 gccagccaga tgtctgacca tgtgacacag aatactctag aggatggcca tacttctgta    540
 gggctgctgc agtttgctgg gggtctgctc ctgaccctag ttgcctcagt ttttcctgta    600
 cctggagata ctaccagtga aggctgcgta acagcaaag                           639



      <210> 1945
      <211> 700
      <212> DNA
      <213> Homo sapiens


      <400> 1945
 tttttttttt ttgttgcaga tagaaacttg tgctttaata tatctctggg tgtgtgagca     60
 tgagtgtgtg cgtgtgtgca agtggaacag ctgtctccag ggcctcagtg cctggcctct    120
 gtccttgttc tctgctcatc cttgcagcca atgcaggccc cctccctggc gggccggccc    180
 tgcccctggg caccccagct ggcgggggtc agtctttggt acaatgtgga cactttggtg    240
 tgccgggggc aaggttgggg gggtggccac acagctctca tcatctctgc aacgccaaga    300
 ggaagatggc catgggcccc cacagctgtg ggctggactg gcagggggct ccactgcccg    360
 gcatcaccac cactttattg ggatccgtct gcttccgggg acactccccc ttcttcagtg    420
 tgacgtcatc tatggcaata tcccccaggt agcccgggcc tcgaaccccc tcaaaaataa    480
 tctggaaggg cccactgggg ctgatgggca catgggcctg ctgccacaca ttgcccttat    540
 tgccactgag agaccaggcg tgcgtgtcca gagccccttt gttccgggac cgcaccagga    600
 ggttgaggga gccgatgtgt ttcccgtaca tgtggtagaa gaaggagaca cagtagaact    660
 ttggcgctgg atttgagagg ggactcacta accttggcac                          700



      <210> 1946
      <211> 834
      <212> DNA
      <213> Homo sapiens


      <400> 1946
 gaattcccgg gtcgagggcc agctctgcga cctggacccc agtgctcact tctacgggca     60
 ctgcggcgag cagcttgagt gccggctgga cacaggcggc gacctgagcc gcggagaggt    120
 gccggaacct ctgtgtgcct gtcgttcgca gagtccgctc tgcgggtccg acggtcacac    180
 ctactcccag atctgccgcc tgcaggaggc ggcccgcgct cggcccgatg ccaacctcac    240
 tgtggcacac ccggggccct gcgaatcggg gccccagatc gtgtcacatc catatgacac    300
 ttggaatgtg acagggcagg atgtgatctt tggctgtgaa gtgtttgcct accccatggc    360
 ctccatcgag tggaggaagg atggcttgga catccagctg ccaggggatg acccccacat    420
 ctctgtgcag tttaggggtg gaccccagag gtttgaggtg actggctggc tgcagatcca    480
 ggctgtgcgt cccagtgatg agggcactta ccgctgcctt gcccgcaatg ccctgggtca    540
 agtggaggcc cctgctagct tgacagtgct cacacctgac cagctgaact ctacaggcat    600
 cccccagctg cgatcactaa acctggttcc tgaggaggag gctgagagtg aagagaatga    660
 cgattactac taggtccaga gctctggccc atgggggtgg gtgagcggct atagtgttca    720
 tccctgctct tgaaagacct ggaaagggag cagggtcctt catcgactgc tttcatgctg    780
 tcagtaggga tgatcatggg aggctatttg actccaaggt agcagtgtgg tagg          834



      <210> 1947
      <211> 635
      <212> DNA
      <213> Homo sapiens


      <400> 1947
 tttcgttgag gagtcacagt tgtgagcaag ttcggtgccg cgggctgggg taggcggcag     60
 tggggtccct ggctttgggg cactgggaag atcgcgagtg ggaaggtcct cccgcggtcc    120
 tccgggtcat ctttcctcct gaggagcagc atatttcgca tctgccggag attagaatta    180
 cttgttattg gtaaatagcc actatggaga ctaaggacca gaagaaacaa agaaagaaaa    240
 atagtggacc caaagctgca aagaaaaaga agcggcatct gcaggatctc cagctaggag    300
 acgaagaaga tgcctggaag agaaatccca aagcttttgc atttcagtct gctgtgtgga    360
 tggctcgatc ctttcacagg actcaggatt tgaagacaaa aaagcatcat attccagtgg    420
 ttgatcgaac tccactagag cccccaccaa tagtggtagt ggtgatgggg cctccaaagt    480
 tggaaagagc actttgatac aatgcctcat tcggaacttc acccggcaga agttgaccga    540
 gatcagaggc cctgtgatga tcgtgtcagg taaaaagctc cgactcacca ttattgattg    600
 tgggtgtgac attaacatga tgattgatct ggctg                               635



      <210> 1948
      <211> 692
      <212> DNA
      <213> Homo sapiens


      <400> 1948
 ggccgggttg gaaaacccag caacgagctt tgaaaacata tcacccggac accaggggca     60
 gaggctgttc tgggcgggag gttgtgcctg ccccacggag cgacagaagc ggggagacca    120
 gacgtcgacc ctgaggcgtg cctcctgggg ggctccagtg gccggcatgg ggtgggtgtg    180
 gactctctgc actgctagtg cctgcctgac cttgctgttc tggagccaga ccccagggaa    240
 agcattccag atcccgtgcc ccccaccaca cctttcccat tggtgcttgt ctcctatgca    300
 aatggatgat ggttgtgctc ggctttgcgt gttgtggacg gcgtggatga gatggagggt    360
 gctcatgtgc tcttgtcggg tgtgggccac agatcttggg atcttccttg gcgtggcctt    420
 ggggaatgag cctttggaga tgtggccctt gacgcaaaat gaggagtgca ctgtcacggg    480
 ttttctgcgg gacaagctgc agtacaggag ccgacttcag tacatgaaac actacttccc    540
 catcaactac aagatcagag tgccttacga gggggtgttc agaatcgcca acgtcaccag    600
 gctgagggcc caggggagcg agcgggagct gcggtatctg ggggtcttgg tgagcctcag    660
 tgccactgag tcggtgcatg acgagctgct cg                                  692



      <210> 1949
      <211> 376
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(376)
      <223> n = a,t,c or g


      <400> 1949
 cgccgctttg tttctcaaga gactgggaat ctgtatattg ccaaagtaga aaaatcagat     60
 gttgggaatt atacctgtgt ggttaccaat accgtgacaa accacaaggt cctggggcca    120
 cctacaccac taatattgag aaatgatgga gtgatgggtg aatatgagcc caaaatagaa    180
 gtgcagttcc cagaaacagt tccgactgca aaaggagcaa cggtgaagct ggaatgcttt    240
 gctttaggaa atccagtacc aactattatc tggcgaagag ctgatggaaa gccaatagca    300
 aggaaagcca gaagacacaa gtcaagagtg gggaaanntc ttgagaaatc ccttaatttt    360
 tcagcaggga ggatgc                                                    376



      <210> 1950
      <211> 462
      <212> DNA
      <213> Homo sapiens


      <400> 1950
 ggaattccag gaggctgcca agctgtacca caccaactat gtgcggaact cgcgggccat     60
 cggcgtgctg tgggccatct tcaccatctg ctttgccatc gtcaacgtgg tgtgcttcat    120
 ccagccctac tggataggcg acggcgtgga caccccgcaa gccggctatt tcgggctctt    180
 ccactactgc atcggcaacg gcttctcccg ggagctgacc tgcaggggca gcttcacgga    240
 cttctccacg ctgccctcgg gcgccttcaa agccgcctcc ttctttatcg gcctctccat    300
 gatgctcatc attgcctgca tcatttgctt taccctcttc ttcttctgca acacggccac    360
 tgtgtacaag atatgtgcct ggatgcagct cacctccgct gcctgccttg tgcttggctg    420
 tatgattttc cctgatggct gggactcaga tgaagtaaac cg                       462



      <210> 1951
      <211> 768
      <212> DNA
      <213> Homo sapiens


      <400> 1951
 tacattgaga cagagctaaa gaagaggaaa ggaaagatgg acagttattt tggtcctata     60
 aagcccaaag gtggggaagt gtcaagaagg aagatgaggg cacaagagaa tgtagggcca    120
 cccaaaagct ggctctcatt gcaattacag aaagaaaaac caaaataaag aaagaaagga    180
 aagaagctcc catttattga gcagctactc tcaccagcca ttcacatgca atacctcgtt    240
 taattctcgc agcggctctg aaaggtggat ggtggtattg ccatttgtta ggtaggagac    300
 atgccgtcca gaaaagcaaa taattaaaca ttcaaagttg acctgggccc atttgaaaat    360
 tccttttgct ccctcatttt aacccctaaa gtaaagccgt ttggtgaact ttaatgagct    420
 tttaccaagc atctcctaaa accaagaatg gaggtgaaag attgtggagc ccacaaccta    480
 gagaaaggat tgacaatttt tttccataaa gggcctagta gtatgtattt taggctgtgt    540
 ggtccacatg agggcagatt cttctttttg acttcctcct ctgcatcttc ttcatcttct    600
 ctttcctctt catttttttt acaacttccg ggacgaggag ctgtcctgca ccgtggtgga    660
 gctgaagtac acaggcaatg ccagcgcact cctcatcctc cccgatcaag acaagatgga    720
 ggaagtggaa gccatgctgc tcccagagac ctttgcccta tgctgcct                 768



      <210> 1952
      <211> 2563
      <212> DNA
      <213> Homo sapiens


      <400> 1952
 ctgatacttt agaaacttta ttgaggacaa aagtgggcgg ctcccagtcc catgggcaga     60
 ccgacaataa ataagggcta aaaggaagaa gtacggcagg gcaggagtgg ttgtctcatc    120
 atggagagcc ctggggggca gcagaaccaa ctggaatgaa acacagggca tcctgccatt    180
 cgagtaatgt agccacaggg ttggtgcaga cccgggtggg gcctgaaggg aggggctcgg    240
 ctggtgtaaa aaggcacact caatcgtcca agacgaagcc tcgtggaagc agtggatggc    300
 ggttaaaaca cgatttgaag gccgctccct tcagggctag gggttccaag ggggccagat    360
 ttgctgaagg cctgcctggc cttgctgggg gtctcaaaag actggaatga acagataggg    420
 gggctggcac aaagcgggtg tttgggaaga gaagatcagg ctggtggttg ctggagccca    480
 ctgactgcag caagggtggt agacttggct ctagacttct atgttccagg gtgcagggct    540
 ctgatgcccc cagctctacc cctagggcag ggccctgggg gtccagactg cccctgggtg    600
 ctgggctgaa ggggcccggg ttctgctgga gggcagggct caggtacctc aagctgttcc    660
 tggcgagagg actccggtat ctcaggctca atcctacagt aggactctag gggcctgggt    720
 tctgctggag ggcagggctc aggtacctca agctgttcct ggcgagagga ctccggtatc    780
 tcaggctcac tcctacagca ggactctagg ggcctgggtt ctgctggagg gtagggctct    840
 ggtacttcaa gctgttcctg gagggagggc tctggtatct caggctcact cctacagaag    900
 gcctctgggg gcccaggctc tgccggaggg cagggctgtg gttccccgca ctcctctgga    960
 agacagggct ttggcagccc tgagtgtttt aacagtccag gaaggtggga agtcccagag   1020
 ttatgctctg tggcattcag agttctagaa atctcagtca gcaggggctg aagttcaacc   1080
 atatccagag aagagcctcc attaagaggg acacactggc cccctaccag cccctctact   1140
 tcctgtctca acagctgttg caggataccg atgcgttgaa tcttcacctc ctggaggctg   1200
 ggggttctgt tagagtgggg tccagaagga gtggccaccg gtggtttccc agaaccctcc   1260
 agtgacctta tacaactctc ctggtcaaac aaccggacgg caacctgctc ccagggcagg   1320
 gcaggatctt cagagcagga ctgaggggag acaccacgca gccactgggc ctgctgaact   1380
 ctgggggttg atggcatggg tgtgaaccgg gttttaggtt gaacggtgag acgccgcaac   1440
 actgaatatg aggtcagagt tggagggcct ggggagggta cacgctgagc ccgtccaaag   1500
 ggtgatggac atggcaccac atggccaggc aagggctggg ccacaggggc aggggagggc   1560
 atcaggtggg agtcatggct gtccctggta tgtgacattt ctcggttttc tcttaatggt   1620
 actcgctggg ccagaccaag agaggccaca cctccttcat ctgagtgagt gacaacctcg   1680
 cgttctcctt taggaagaga gaaagcaggc tggactgggg tctccaggag caatcctgag   1740
 gcctggctca ctgaagtccg gctgctgcca gctgtctccc ttcttagctc ctggaaactg   1800
 gggcgagtgg aagggtgaaa ggaaggtcct gaaggtgaaa tcagagcctg tagcctctgg   1860
 gggcacaatg tccggcctcg aggtcctggt ccctccagcc tagagaagca ggaagccctg   1920
 gcagggtcca gtcggtgggt gggggttctg ggggccaaat atgcagaggc ccgaacaccc   1980
 tggaccctct gggtggtgcc tccctgactt cctcgaacca gtactctttt agccagacta   2040
 ggctggcgcc ccaggtgaca gctcttcaca ccctcacctg acaggatggt ggccagggct   2100
 gcagggtcag ccacaaactc tatggtccct ggagcctctg tctgggcagg gggcccaggc   2160
 cccacatttt gacccctagg gctaggcctg agctcttcca aggggttccg aggctgactg   2220
 atccccacca atctttgtga tgtctctgcc tggtgcctgg ctttcggcct ggggcctgct   2280
 gaatcaacga gggggcgttg aatattgagc ggtggtttct gcacccatct ccttggatct   2340
 tggttctcct ggtccacggc gcacgatgta acagtgggga aaggcgtgcg tttctgagag   2400
 cgtaccggaa tcttgctagg ggtaggagat acaccccgga ggaggggatc cttcgtggct   2460
 tgccgggtgg tcatgatggc ttaccgagag cccctcaggg cctacccagc ttcctccgct   2520
 tttctcctga ccctctcggg tgctgctgga gctactttcc cag                     2563



      <210> 1953
      <211> 2128
      <212> DNA
      <213> Homo sapiens


      <400> 1953
 tcataattta ggggtttctg tcttttaaat gctatccatt gagggcccga atggaacaaa     60
 acagagagac aggagttcgc ctccttttgt ttttctgcct cactgttgag ctgggtgatc    120
 tcatctcatc tttttttgcc cttggactgg gacttagccc cattggcccc ctggttctca    180
 ggccttcagc ctgagttaca ccaccagctt tcttgggtct cagtttgcaa atggcagatc    240
 gtgggacttc gcaaacacca tcatcttgta agcccattcc tcctaatctt cttttatata    300
 cacaccaatt ggttctgttt ctctggaaaa cctgattaat agacctgagg aatgaaactg    360
 taacctctca gtgggttctt cttgcctgag cctggcgtcc gtgtggctgg cgcggaggat    420
 gtggacgctg cggagcccgc tcacccgctc cctgtacgtg aacatgacta gcggcccggg    480
 tgggccggcg gcggccgcgg gcggcaggaa ggagaaccac cagtggtatg tgtgcaacag    540
 agagaaatta tgcgaatcac tccaggctgt ctttgttcag agttaccttg atcaaggaac    600
 acagatcttc ttaaacaaca gcattgagaa atcgggctgg ctatttatcc aattatatca    660
 ttcttttgtg tcatctgttt ttagcctgtt tatgtctaga acatctatca atgggttgct    720
 aggaagaggc tcaatgtttg tgttttcacc agatcagttt cagagactgc ttaaaattaa    780
 tccagactgg aaaacccaca gacttcttga tttaggtgct ggagatggag aagtcacaaa    840
 aatcatgagc cctcattttg aagaaatcta tgccactgag ctttctgaaa ctatgatatg    900
 gcagcttcag aaaaagaaat acagagtcct tggtataaat gaatggcaga atacggggtt    960
 ccagtatgat gtcatcagct gcctgaactt gctggaccgc tgtgatcagc ccctgacttt   1020
 gttaaaagat atcagaagtg tcttggagcc aactagaggc agggtcatcc ttgcccttgt   1080
 cctccccttt catccctatg tggaaaacgt aggtggcaag tgggagaaac catcagaaat   1140
 tttggaaatc aaaggacaga actgggaaga acaagtgaat agtctgcctg aagttttcag   1200
 aaaagctggt tttgttatcg aagctttcac cagactacca tacctgtgtg aaggcgacat   1260
 gtataatgac tactacgttc tggatgacgc tgtctttgtt ctcaaaccag tataaacacg   1320
 tggaggtcga agtcttcaga gtccgcaccc tccgggatgt gcccttggaa gagggtctgt   1380
 gttcacaatt acgtgaaggg aggacccttg gggaccgcca ttctaaatat catgtaggaa   1440
 tttaaaaagc caaaatacta attatttctt tgtagtgtgt aaaggaatgt ttttaaaaga   1500
 caaaaaccca actctttgtg gatttttatc aactctttac tcagagccac tctccaatgc   1560
 aggtcacact ccaattatga tggaagatat tttttatact taattgcagt agggactcat   1620
 tcccagacaa agcaatagtc acgacttcat ggaaccaatc aatggattgt tttttgaaga   1680
 ctggcaataa agctgtccat tcaattccaa atactggttt taaggtatag ccactgatat   1740
 tctttcatgt ttagaaattc tttctgttat tattcaagaa aatgttttta atcatgctaa   1800
 taaacttttt tggagatgac tttggcatca tgtttgaatt catataaagc tcccctagca   1860
 ttttttattg gtttggcttc aggagtaccc aaatagtagc attatgagaa tgacgcagac   1920
 aatttgaata ggggggaagg aaggcttcag acttggggga aggggagatt attgcaaatt   1980
 gcagtgaaca ctgagtcagt aaaaaaaaaa aacagaaaca agatcaccca gcatccttcc   2040
 ccaccccagc tgtgtattta tatagaggga aatatacttt atattttgta tcatcgggcc   2100
 tatagccgct gccaccgtgt ataaatct                                      2128



      <210> 1954
      <211> 377
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(377)
      <223> n = a,t,c or g


      <400> 1954
 nggccccttt atgagaacct ttacgttcgt cctgaccaca cccttgtcac ccccaggccc     60
 gggtgctgcg cagcccccgg gatgcagtac aatgcctcca gcgccttgcc ggatgacatc    120
 ctcaactttg tcaagaccca ccctctgatg gacgaggcgg tgccctcgct gggccatgcg    180
 ccctggatcc tgcggaccct gatgaggtcg gtcctggaga ggcagggcat ggcgagggga    240
 gacaggatgg ggtagatgga gggtgagagg atccagatgc tcaacacaga tgagcccatg    300
 gcttccggcg ctgcccagag agctggagac acagagagac agagagggaa agatggagag    360
 acaccaggaa ttgtatt                                                   377



      <210> 1955
      <211> 1196
      <212> DNA
      <213> Homo sapiens


      <400> 1955
 ccggccggat tcctgggcga catttccgca ctgggcgcgc gagagctgct agggcggttt     60
 ctctgcctcg ggcctgttgg gcagggccgg ctaaggtgcg cgtgctcgct ggttctaacc    120
 cttctgttgg gcgtttctgc ggagaggcgg gaggcgctga gagtctgtgc ggaggtccat    180
 gcacagactg ctttgcctgt tgttgctctt cggaggcggc gatccccgaa ggcgagctga    240
 aatacggctg caggctacaa tttgcagccg acgattaagg aagacgacga gcgggagagg    300
 tggcccaccc tcatggagcg cttgtgctcg gatggcttcg catttcccca ttactacatt    360
 aaaccgtatc atctgaagag gatccacaga gctgtcttac gtggtaatct ggagaaactg    420
 aagtaccttc tgctcacgta ttatgacgcc aataagagag acaggaagga aaggactgcc    480
 ctacatttgg cctgtgccac tggccaaccg gaaatggtac atctcctggt gtccagaaga    540
 tgtgagctta acctctgcga ccgtgaagac aggacacctc tgatcaaggc tgtacaactg    600
 aggcaggagg cttgtgcaac tcttctgctg caaaatggcg cccgatccaa atattacgga    660
 tgtctttgga aggactgctc tgcactacgc tgtgtataat gaagatacat ccatgataga    720
 aaaacttctt tcacatggta caaatattga agaatgcagc aaggtatagg tcaaccaatg    780
 ttattttcaa actatctgaa atgcatttat tttaacattg acacatgtaa gggtcaattt    840
 ttcatatttg gaagctcaaa cattccttga atgaaaatat tttgaaatgc cttaactgtc    900
 taagatttta ctttaaatat tggaactttt aaagaagcat tatagggaac agcctttttt    960
 catgcactta tggtaaataa ctataaaaac aaatgaatta caataaattt ataattcatg   1020
 acaactgaat ttgggaaagg taatagttaa gtgtttttcc cctaaattac tttttttcta   1080
 atcagtgtga agtgacacag gaaagtaaaa ttgtccctta taaataggct ttattttaaa   1140
 tgtcaaagaa aattaaagaa tttcccaata aatgtacatg ttgttgctgt tgaaaa       1196



      <210> 1956
      <211> 1536
      <212> DNA
      <213> Homo sapiens


      <400> 1956
 cggccgcgac cactaccacc actgagcacc gcttcttccg ccggagcgtc atctgcgact     60
 ccaatgccac tgcactggag cttcccggcc ttcctctttc cctgccccag cccagcatcc    120
 ccgcggctgt cccgcagagt gctccaccgg agccccaccg ggaagagacc gtgaccgcca    180
 ccgccacttc ccaggtagcc cagcagcctc cagccgctgc cgcccctggg gaacaggccg    240
 tcgcgggccc tgccccctcg actgtcccca gcagtaccag caaagaccgc ccagtgtccc    300
 agcctagcct tgtggggagc aaagaggagc cgccgccggc gagaagtggc agcggcggcg    360
 gcagcgccaa ggagccacag gaggaacgga gccagcagca ggatgatatc gaagagctgg    420
 agaccaaggc cgtgggaatg tctaacgatg gccgctttct caagtttgac atcgaaatcg    480
 gcagaggctc ctttaagacg gtctacaaag gtctggacac tgaaaccacc gtggaagtcg    540
 cctggtgtga actgcaggat cgaaaattaa caaagtctga gaggcagaga tttaaagaag    600
 aagctgaaat gttaaaaggt cttcagcatc ccaatattgt tagattttat gattcctggg    660
 aatccacagt aaaaggaaag aagtgcattg ttttggtgac tgaacttatg acgtctggaa    720
 cacttaaaac gtatctgaaa aggtttaaag tgatgaagat caaagttcta agaagctggt    780
 gccgtcagat ccttaaaggt cttcagtttc ttcatactcg aactccacct atcattcacc    840
 gcgatcttaa atgtgacaac atctttatca ccggccctac tggctcagtc aagattggag    900
 acctcggtct ggcaaccctg aagcgggctt cttttgccaa gagtgtgata ggtaccccag    960
 agttcatggc ccctgagatg tatgaggaga aatatgatga atccgttgac gtttatgctt   1020
 ttgggatgtg catgcttgag atggctacat ctgaatatcc ttactcggag tgccaaaatg   1080
 ctgcacagat ctaccgtcgc gtgaccagtg gggtgaagcc agccagtttt gacaaagtag   1140
 caattcctga agtgaaggaa attattgaag gatgcatacg acaaaacaaa gatgaaagat   1200
 attccatcaa agaccttttg aaccatgcct tcttccaaga ggaaacagga gtacgggtag   1260
 aattagcaga agaagatgat ggagaaaaaa tagccataaa attatggcta cgtattgaag   1320
 atattaagaa attaaaggga aaatacaaag ataatgaagc tattgagttt tcttttgatt   1380
 tagagagaaa tgtcccagaa gatgttgcac aagaaatggt agagtctggg tatgtctgtg   1440
 aaggtgatca caagaccatg gctaaagcta tcaaagacag agtatcatta attaagagga   1500
 aacgagagca gcggcagttg gtacgggagg agcaag                             1536



      <210> 1957
      <211> 1536
      <212> DNA
      <213> Homo sapiens


      <400> 1957
 cggccgcgac cactaccacc actgagcacc gcttcttccg ccggagcgtc atctgcgact     60
 ccaatgccac tgcactggag cttcccggcc ttcctctttc cctgccccag cccagcatcc    120
 ccgcggctgt cccgcagagt gctccaccgg agccccaccg ggaagagacc gtgaccgcca    180
 ccgccacttc ccaggtagcc cagcagcctc cagccgctgc cgcccctggg gaacaggccg    240
 tcgcgggccc tgccccctcg actgtcccca gcagtaccag caaagaccgc ccagtgtccc    300
 agcctagcct tgtggggagc aaagaggagc cgccgccggc gagaagtggc agcggcggcg    360
 gcagcgccaa ggagccacag gaggaacgga gccagcagca ggatgatatc gaagagctgg    420
 agaccaaggc cgtgggaatg tctaacgatg gccgctttct caagtttgac atcgaaatcg    480
 gcagaggctc ctttaagacg gtctacaaag gtctggacac tgaaaccacc gtggaagtcg    540
 cctggtgtga actgcaggat cgaaaattaa caaagtctga gaggcagaga tttaaagaag    600
 aagctgaaat gttaaaaggt cttcagcatc ccaatattgt tagattttat gattcctggg    660
 aatccacagt aaaaggaaag aagtgcattg ttttggtgac tgaacttatg acgtctggaa    720
 cacttaaaac gtatctgaaa aggtttaaag tgatgaagat caaagttcta agaagctggt    780
 gccgtcagat ccttaaaggt cttcagtttc ttcatactcg aactccacct atcattcacc    840
 gcgatcttaa atgtgacaac atctttatca ccggccctac tggctcagtc aagattggag    900
 acctcggtct ggcaaccctg aagcgggctt cttttgccaa gagtgtgata ggtaccccag    960
 agttcatggc ccctgagatg tatgaggaga aatatgatga atccgttgac gtttatgctt   1020
 ttgggatgtg catgcttgag atggctacat ctgaatatcc ttactcggag tgccaaaatg   1080
 ctgcacagat ctaccgtcgc gtgaccagtg gggtgaagcc agccagtttt gacaaagtag   1140
 caattcctga agtgaaggaa attattgaag gatgcatacg acaaaacaaa gatgaaagat   1200
 attccatcaa agaccttttg aaccatgcct tcttccaaga ggaaacagga gtacgggtag   1260
 aattagcaga agaagatgat ggagaaaaaa tagccataaa attatggcta cgtattgaag   1320
 atattaagaa attaaaggga aaatacaaag ataatgaagc tattgagttt tcttttgatt   1380
 tagagagaaa tgtcccagaa gatgttgcac aagaaatggt agagtctggg tatgtctgtg   1440
 aaggtgatca caagaccatg gctaaagcta tcaaagacag agtatcatta attaagagga   1500
 aacgagagca gcggcagttg gtacgggagg agcaag                             1536



      <210> 1958
      <211> 448
      <212> DNA
      <213> Homo sapiens


      <400> 1958
 attggtgcat atatcaataa ttaatttcct tttattggct gagtagtatt tactatatgg     60
 atgtaccaca ttttgtttat cctttcaact gttgctggac atttgggttg tttccagttt    120
 tgaggctata taaacaaaga cacaaagatt tgtatgtaaa gcatcgtatg gacagccacc    180
 ttatttctct tggagcagaa agggacctta aagatgacag accaaacatc aacttcacag    240
 atgatgacac agaaggtgaa tctactgaaa agagctaaag aaagacaaat ctcttgaggc    300
 agatgaaggg aatgcaaata ttcaaagacc ctgcagaaaa tcagtcaaca agatgctgtt    360
 tgtcttggtc ttagtgtttg ctatctgttg ggccccgttt ccacattgac cgactcttct    420
 tcagctttgt ggaggagtgg agtgaatc                                       448



      <210> 1959
      <211> 512
      <212> DNA
      <213> Homo sapiens


      <400> 1959
 gacgaggagc tgcccgacct gtccgtgtct cgcagaagta gccacttgca ctggggcatt     60
 ccggtgccgg ggtatgattc gcagaccatc tatgtatggc tggatgccct ggtcaactac    120
 ctcactgtaa ttggctaccc aaatgctgag ttcaaatctt ggtggccggc cacctctcat    180
 atcataggta aggacattct caaattccat gccatctatt ggcctgcctt cctgttaggg    240
 gccggcatga gcccgccaca gcgcatctgt gtccattccc actggacagt ctgtggccaa    300
 aagatgtcca agagcttggg caacgtggtg gatcctagga cttgccttaa ccgctatacc    360
 gtggatggct tccgctactt tctccttcgg cagggcgtcc ccaactggga ctgtgactac    420
 tatgatgaaa aggtggttaa gttgctgaac tccgagctgg cagatgcctt gggaggtctc    480
 ttgaaccgat gcactgccaa aagaataaat cc                                  512



      <210> 1960
      <211> 1194
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1194)
      <223> n = a,t,c or g


      <400> 1960
 gataggactt ttttattgaa gattggtaaa tggtgcactc taagctatgg aaagaaggtt     60
 acaaataaag ggattttata taagaaagga tcttgtatag taaattcttg tcctaaaagg    120
 aaatgactgg ttgtttaaga caagtcagaa agttgagtac attgtaagag ggtctgtgaa    180
 agtcatgaaa gaatttaata attaagaaat ttaataatta aaggaaagga attgccaaga    240
 ttaacaccaa agttatttta gccacccaat aacgtttttc tcccaatcat atcataagtt    300
 ataaagaatg gcctaaacca aaaattatgc cctaatagca agtcaagggg gaaacatgtt    360
 ttctcaaagg aaatgatgct tttatattaa cgtttctggt aatgtacagc gacatctagt    420
 ggagacaaac cagtattaca atccattggt gtaacaggta tcaaactcta ctgccatagt    480
 tacagtctat aggtggtaat cttaatactc atatggtaac cctatatttt aaaccttctt    540
 gtaaaattta tctctttttg cctagaagca atcaaacttc aaatggtgct gcaaacaaag    600
 ccacacatgg acatgccatt ctttccagga aagccttaga tcaacctcag gaggagcccc    660
 aactgcagcc ccccgacacg acgccccttt tcagcaggaa gtagccagaa agaatcgtcg    720
 tccaacaccc cctaacagca gttatggtta cgtctcctcg gcgctgccgg atgagtggct    780
 ccatcagctc gtacttgtgt ctgcacacct tgtccacctc ggctcgcttc cgttccataa    840
 agtccttctg gctattgaag tactcgccta tgggccgccc cagctccatc actgctagga    900
 actcccccac tgcgctgtca aaatgcacgt attcctcccg gttgtagatg agcccgtcca    960
 caacgcgctg agtcccattg aacgcatagc attcctgccg ttcctggtag acggaattct   1020
 ctggagtggc cctgctctgg accacagata tgagcagcac catcagtaat gctgtcagag   1080
 ccactgtcca ggggccccct gaaacctgca ggatcatcct ccagttggaa aaggttggca   1140
 gaataaaaaa agctgcagtc aggaaaaccg nnngcgtggg tcgccgctgg tctt         1194



      <210> 1961
      <211> 1026
      <212> DNA
      <213> Homo sapiens


      <400> 1961
 tttttttttt ttgagaaaca tcagggactt taatcacatc ccgcagctct gggaacctgc     60
 ccaggcgctg atgctgcgca cagcccaccc ccattccctc cctcccgccc tcctggccct    120
 ggccagctca gctctgtccg gggtcggaga gggggtcctg aggcagcagc agcccagctc    180
 cagagtgaca ggcaggggct gtccagctga gtctccgccc ccacgttgcc ctggggcagg    240
 cccagctgct gtcagtgctg cttgagacac taagcagcat cttccaagga caggttggcc    300
 aagtgtgggg gctccaaaca ccttaaggct ggcaatacca ggaaggccgg ggcggctctg    360
 tgtgtcccag gccaggagaa ggcagaggag cgtggtctca tgctcgtgtc ctgtttgtgc    420
 cagttattta tgtagttcag gaggccctgg acagctgact tccactgcgc cgaggactcg    480
 cagttatagc caaagcaggc gacgtgcgag tctgtgcagt tgttgcagga gatggtctcg    540
 tactggaaga tgccacagcg gtgctgacag tcgatgcggc tttcgatgat ggcgttctgg    600
 atgaggtgca cctgctcccg gaagatgttt cgcagctcgt tggggaaata cccggggaag    660
 tacatcttcc cctggtacag ctgatccatc atctggtaca ctgctgtcgc cacttggtcc    720
 agcttctccc gggtgatctt ggcggggatg gccaggtgca gctccttcat cgtgtcgtcg    780
 ctccagtcgg tgagcagcgc ccctgacacg gggatgtcgc ccacccacca ggacttgaag    840
 ttcacatggt ggcggtagaa ggagaacttc ttggagaagt tgctgtggca gtgcagacag    900
 ccgtgggcca gcgccgccgt caggcacacc aggcacagca gcagggccat gcccgtcccg    960
 gcccgccgcc ggccaaccaa cgacgctgct cgcgccacac ccttaattcc accacgctgg   1020
 gtagat                                                              1026



      <210> 1962
      <211> 1026
      <212> DNA
      <213> Homo sapiens


      <400> 1962
 tttttttttt ttgagaaaca tcagggactt taatcacatc ccgcagctct gggaacctgc     60
 ccaggcgctg atgctgcgca cagcccaccc ccattccctc cctcccgccc tcctggccct    120
 ggccagctca gctctgtccg gggtcggaga gggggtcctg aggcagcagc agcccagctc    180
 cagagtgaca ggcaggggct gtccagctga gtctccgccc ccacgttgcc ctggggcagg    240
 cccagctgct gtcagtgctg cttgagacac taagcagcat cttccaagga caggttggcc    300
 aagtgtgggg gctccaaaca ccttaaggct ggcaatacca ggaaggccgg ggcggctctg    360
 tgtgtcccag gccaggagaa ggcagaggag cgtggtctca tgctcgtgtc ctgtttgtgc    420
 cagttattta tgtagttcag gaggccctgg acagctgact tccactgcgc cgaggactcg    480
 cagttatagc caaagcaggc gacgtgcgag tctgtgcagt tgttgcagga gatggtctcg    540
 tactggaaga tgccacagcg gtgctgacag tcgatgcggc tttcgatgat ggcgttctgg    600
 atgaggtgca cctgctcccg gaagatgttt cgcagctcgt tggggaaata cccggggaag    660
 tacatcttcc cctggtacag ctgatccatc atctggtaca ctgctgtcgc cacttggtcc    720
 agcttctccc gggtgatctt ggcggggatg gccaggtgca gctccttcat cgtgtcgtcg    780
 ctccagtcgg tgagcagcgc ccctgacacg gggatgtcgc ccacccacca ggacttgaag    840
 ttcacatggt ggcggtagaa ggagaacttc ttggagaagt tgctgtggca gtgcagacag    900
 ccgtgggcca gcgccgccgt caggcacacc aggcacagca gcagggccat gcccgtcccg    960
 gcccgccgcc ggccaaccaa cgacgctgct cgcgccacac ccttaattcc accacgctgg   1020
 gtagat                                                              1026



      <210> 1963
      <211> 536
      <212> DNA
      <213> Homo sapiens


      <400> 1963
 gcctgtgtgt ctctgtgctt tgctccttct cctacctcca aaatggctgg actgcctccg     60
 atccagttca tggctactgg ttcaggggca ggggaccatg taagccggaa cattccagtg    120
 gccacaaaca acccagttcg agcagtgcag gaggagactc gggaccgatt ccacctcctt    180
 ggggacccac agaacaagga ttgtaccctg agcatcagag acaccagaga gagtgatgca    240
 gggacatacg tcttttgtgt agagagagga aatatgaaat ggaattataa atatgaccag    300
 ctctctgtga atgtgacagc gtcccaggac ctactgtcaa gatacaggct ggaggtgcca    360
 gagtcggtga ctgtgcagga gggtctgtgt gtctctgtgc cctgcagtgt cctttacccc    420
 cattacaact ggactgcctc tagccctgtt tatggatcct gggtcaagga aggggccgat    480
 ataccatggg atattccagt ggccacaaac accccaagtg gaaaagtgca agagga        536



      <210> 1964
      <211> 1129
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1129)
      <223> n = a,t,c or g


      <400> 1964
 ccgggtcgac ccacgcgttc gaacaattcc ggcttcgctg cgactcatac ctcatcttta     60
 acatatgcat tttgaagaaa gatggctgag atggacagaa tgctttattt tggaaagaaa    120
 caatgttcta ggtcaaactg agtctaccaa atgcagactt tcacaatggt tctagaagaa    180
 atctggacaa gtcttttcat gtgggttttc tacgcattga ttccatgttt gnnnnnnnnn    240
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnngtgaggc ccttcattag    300
 acactaattt gaagctatgg cattccccca ctatgagccc acctgtcagc caggctatct    360
 gccttgatcc tagatgaagt ggccattctg cctgcccctc agaacctctc tgtactctca    420
 accaacatga agcatctctt gatgtggagc ccagtgatcg cgcctggaga aacagtgtac    480
 tattctgtcg aataccaggg ggagtacgag agcctgtaca cgagccacat ctggatcccc    540
 agcagctggt gctcactcac tgaaggtcct gagtgtgatg tcactgatga catcacggcc    600
 actgtgccat acaaccttcg tgtcagggcc acattgggct cacagacctc agcctggagc    660
 atcctgaagc atccctttaa tagaaactca accatcctta cccgacctgg gatggagatc    720
 accaaagatg gcttccacct ggttattgag ctggaggacc tggggcccca gtttgagttc    780
 cttgtggcct actggaggag ggagcctggt gccgaggaac atgtcaaaat ggtgaggagt    840
 gggggtattc cagtgcacct agaaaccatg gagccagggg ctgcatactg tgtgaaggcc    900
 cagacattcg tgaaggccat tgggaggtac agcgccttca gccagacaga atgtgtggag    960
 gtgcaaggag aggccattcc cctggtactg gccctgtttg cctttgttgg cttcatgctg   1020
 atccttgtgg tcgtgccact gttcgtctgg aaaatgggcc ggctgctcca gtactcctgt   1080
 tgccccgtgg tgggtcctcc cagacacctt ggaaaataac ccaattcac               1129



      <210> 1965
      <211> 359
      <212> DNA
      <213> Homo sapiens


      <400> 1965
 atctcaggag aatccattta ctggagccag aaacctactc catcatcgaa cgccagccct     60
 tggtctgagc ctgcggctgt agatgtggaa ctcacagcat atgcattgtt ggcccagctt    120
 accaagccca gcctgactca aaaggagata gcgaaggcca ctagcatagt ggcttggttg    180
 gccaagcaac gcaatgcata tgggggcttc tcttctactc aggatactgt agttgctctc    240
 caagctcttg ccaaatatgc cactaccgcc tacgtgccat ctgaggagat caacctggtt    300
 gtaaaatcca ctgagaattt ccagcgcaca ttcaacatac aggcagttaa ccgaatggg     359



      <210> 1966
      <211> 505
      <212> DNA
      <213> Homo sapiens


      <400> 1966
 cagcataata tgtatcaaag tcatgcttaa acagctgtgg ggagtagagg agtatagaag     60
 aggcaacagg ttccaggatt ggcgtcttaa cacaaaatgc aactaacatg ggactttcag    120
 ttatcatttc ctttatatat ggatgggaga tgacattcct gattctgagt attgctccag    180
 tacttgccgt gacaggaatg attgaaaccg cagcaatgac tggatttgcc aacaaagata    240
 agcaagaact taagcatgct ggaaagcaac tgaagctttg gagaatatac gtactatagt    300
 gtcattaaca agggaaaaag ccttcgagca aatgtatgaa gagatgcttc agactcaaca    360
 cagaaatacc tcgaacaaaa cacagattat tggaagctga tatgcatctc ggacatgcct    420
 ttatatattc tggctatgca acagggtttc gatgtggagc ctatgtaatt ccagctggac    480
 gaatgacccc agagggcatg ttcat                                          505



      <210> 1967
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 1967
 Asp Pro Lys Ala Gln Leu Pro Glu Pro Leu Arg Val Leu Trp Thr Ala
   1               5                  10                  15    
 His Leu Val Ala Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala
              20                  25                  30        
 Phe Ala Leu Leu Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln
          35                  40                  45            
 Thr Val Pro Leu Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His
      50                  55                  60                
 Arg Ala His Gln Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr
  65                  70                  75                  80
 Tyr Ile Pro Lys Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr
                  85                  90                  95    
 Ser Phe Cys Phe Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu
             100                 105                 110        
 Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu
         115                 120                 125            
 Ile Glu Ser Trp Leu Glu Pro Val Arg Ile Leu Met Ser Ile Val Pro
     130                 135                 140                
 Asn
 145



      <210> 1968
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 1968
 Asp Pro Lys Ala Gln Leu Pro Glu Pro Leu Arg Val Leu Trp Thr Ala
   1               5                  10                  15    
 His Leu Val Ala Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala
              20                  25                  30        
 Phe Ala Leu Leu Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln
          35                  40                  45            
 Thr Val Pro Leu Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His
      50                  55                  60                
 Arg Ala His Gln Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr
  65                  70                  75                  80
 Tyr Ile Pro Lys Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr
                  85                  90                  95    
 Ser Phe Cys Phe Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu
             100                 105                 110        
 Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu
         115                 120                 125            
 Ile Glu Ser Trp Leu Glu Pro Val Arg Ile Leu Met Ser Ile Val Pro
     130                 135                 140                
 Asn
 145



      <210> 1969
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 1969
 Asp Pro Lys Ala Gln Leu Pro Glu Pro Leu Arg Val Leu Trp Thr Ala
   1               5                  10                  15    
 His Leu Val Ala Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala
              20                  25                  30        
 Phe Ala Leu Leu Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln
          35                  40                  45            
 Thr Val Pro Leu Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His
      50                  55                  60                
 Arg Ala His Gln Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr
  65                  70                  75                  80
 Tyr Ile Pro Lys Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr
                  85                  90                  95    
 Ser Phe Cys Phe Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu
             100                 105                 110        
 Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu
         115                 120                 125            
 Ile Glu Ser Trp Leu Glu Pro Val Arg Ile Leu Met Ser Ile Val Pro
     130                 135                 140                
 Asn
 145



      <210> 1970
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 1970
 Asp Pro Lys Ala Gln Leu Pro Glu Pro Leu Arg Val Leu Trp Thr Ala
   1               5                  10                  15    
 His Leu Val Ala Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala
              20                  25                  30        
 Phe Ala Leu Leu Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln
          35                  40                  45            
 Thr Val Pro Leu Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His
      50                  55                  60                
 Arg Ala His Gln Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr
  65                  70                  75                  80
 Tyr Ile Pro Lys Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr
                  85                  90                  95    
 Ser Phe Cys Phe Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu
             100                 105                 110        
 Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu
         115                 120                 125            
 Ile Glu Ser Trp Leu Glu Pro Val Arg Ile Leu Met Ser Ile Val Pro
     130                 135                 140                
 Asn
 145



      <210> 1971
      <211> 452
      <212> PRT
      <213> Homo sapiens


      <400> 1971
 Lys Ala Ala Lys Lys Ala Leu Cys Trp Leu Glu Pro Pro Gln Cys Ala
   1               5                  10                  15    
 Gly Leu Glu Gly Leu Gly Trp Val Trp Ser Cys Ser Val Ser Thr Gly
              20                  25                  30        
 Pro Arg Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu
          35                  40                  45            
 Gly His Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser
      50                  55                  60                
 Pro Asp Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe
  65                  70                  75                  80
 Phe Lys Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly
                  85                  90                  95    
 Tyr Asp Leu Tyr Arg Val Arg Ser Ser Met Ser Pro Thr Thr Asn Val
             100                 105                 110        
 Leu Leu Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu
         115                 120                 125            
 Gly Ala Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr
     130                 135                 140                
 Asp Leu Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu
 145                 150                 155                 160
 Asp Thr Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile
                 165                 170                 175    
 Val Phe Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu
             180                 185                 190        
 Glu Lys Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg
         195                 200                 205            
 Leu Asp Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly
     210                 215                 220                
 Lys Leu Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu
 225                 230                 235                 240
 Leu Leu Gly Val Ala His Phe Lys Gly Gln Trp Glu Thr Lys Phe Asp
                 245                 250                 255    
 Ser Arg Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr
             260                 265                 270        
 Val Arg Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly
         275                 280                 285            
 Leu Asp Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly
     290                 295                 300                
 Ser Met Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu
 305                 310                 315                 320
 Thr Leu Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp
                 325                 330                 335    
 Arg Glu Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys
             340                 345                 350        
 Leu Ser Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu
         355                 360                 365            
 Gln Ser Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro
     370                 375                 380                
 Ile Lys Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu
 385                 390                 395                 400
 Asp Gly Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu
                 405                 410                 415    
 Thr Phe Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu
             420                 425                 430        
 Arg Asp Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp
         435                 440                 445            
 Pro Arg Gly Pro
     450        



      <210> 1972
      <211> 47
      <212> PRT
      <213> Homo sapiens


      <400> 1972
 Gln Pro Leu Asn His Tyr Phe Ile Cys Ser Ser His Asn Thr Tyr Leu
   1               5                  10                  15    
 Val Gly Asp Gln Leu Cys Gly Gln Ser Ser Val Glu Gly Tyr Ile Arg
              20                  25                  30        
 Cys Ser Gly Gly Arg Glu Gly Val Gln Leu Met Arg Gly Thr Met
          35                  40                  45        



      <210> 1973
      <211> 705
      <212> PRT
      <213> Homo sapiens


      <400> 1973
 Phe Val Val Ala Ala Ser Gly Gly Cys Trp Phe Val Leu Gly Glu Arg
   1               5                  10                  15    
 Arg Ala Gly Ser Leu Leu Ser Ala Ser Tyr Gly Thr Phe Ala Met Pro
              20                  25                  30        
 Gly Met Val Leu Phe Gly Arg Arg Trp Ala Ile Ala Ser Asp Asp Leu
          35                  40                  45            
 Val Phe Pro Gly Phe Phe Glu Leu Val Val Arg Val Leu Trp Trp Ile
      50                  55                  60                
 Gly Ile Leu Thr Leu Tyr Leu Met His Arg Gly Lys Leu Asp Cys Ala
  65                  70                  75                  80
 Gly Gly Ala Leu Leu Ser Ser Tyr Leu Ile Val Leu Met Ile Leu Leu
                  85                  90                  95    
 Ala Val Val Ile Cys Thr Val Ser Ala Ile Met Cys Val Ser Met Arg
             100                 105                 110        
 Gly Thr Ile Cys Asn Pro Gly Pro Arg Lys Ser Met Ser Lys Leu Leu
         115                 120                 125            
 Tyr Ile Arg Leu Ala Leu Phe Phe Pro Glu Met Val Trp Ala Ser Leu
     130                 135                 140                
 Gly Ala Ala Trp Val Ala Asp Gly Val Gln Cys Asp Arg Thr Val Val
 145                 150                 155                 160
 Asn Gly Ile Ile Ala Thr Val Val Val Ser Trp Ile Ile Ile Ala Ala
                 165                 170                 175    
 Thr Val Val Ser Ile Ile Ile Val Phe Asp Pro Leu Gly Gly Lys Met
             180                 185                 190        
 Ala Pro Tyr Ser Ser Ala Gly Pro Ser His Leu Asp Ser His Asp Ser
         195                 200                 205            
 Ser Gln Leu Leu Asn Gly Leu Lys Thr Ala Ala Thr Ser Val Trp Glu
     210                 215                 220                
 Thr Arg Ile Lys Leu Leu Cys Cys Cys Ile Gly Lys Asp Asp His Thr
 225                 230                 235                 240
 Arg Val Ala Phe Ser Ser Thr Ala Glu Leu Phe Ser Thr Tyr Phe Ser
                 245                 250                 255    
 Asp Thr Asp Leu Val Pro Ser Asp Ile Ala Ala Gly Leu Ala Leu Leu
             260                 265                 270        
 His Gln Gln Gln Asp Asn Ile Arg Asn Asn Gln Glu Pro Ala Gln Val
         275                 280                 285            
 Val Cys His Ala Pro Gly Ser Ser Gln Glu Ala Asp Leu Asp Ala Glu
     290                 295                 300                
 Leu Lys Asn Cys His His Tyr Met Gln Phe Ala Ala Ala Ala Tyr Gly
 305                 310                 315                 320
 Trp Pro Leu Tyr Ile Tyr Arg Asn Pro Leu Thr Gly Leu Cys Arg Ile
                 325                 330                 335    
 Gly Gly Asp Cys Cys Arg Ser Lys Asn Pro Gln Thr Met Thr Met Val
             340                 345                 350        
 Gly Gly Asp Gln Leu Gln Leu Cys Thr Ser Ala Pro Ile Leu His Thr
         355                 360                 365            
 His Arg Ala Ala Val Gln Gly Leu His Pro Arg Gln Leu Pro Trp Thr
     370                 375                 380                
 Arg Phe Thr Glu Leu Pro Phe Leu Val Ala Leu Asp His Arg Lys Glu
 385                 390                 395                 400
 Ser Val Val Val Ala Val Arg Gly Thr Met Ser Leu Gln Asp Val Leu
                 405                 410                 415    
 Thr Asp Leu Ser Ala Glu Ser Glu Val Leu Asp Val Glu Cys Glu Val
             420                 425                 430        
 Gln Asp Arg Leu Ala His Lys Gly Ile Ser Gln Ala Ala Arg Tyr Val
         435                 440                 445            
 Tyr Gln Arg Leu Ile Asn Asp Gly Ile Leu Ser Gln Ala Phe Ser Ile
     450                 455                 460                
 Ala Pro Glu Tyr Arg Leu Val Ile Val Gly His Ser Leu Gly Gly Gly
 465                 470                 475                 480
 Ala Ala Ala Leu Leu Ala Thr Met Val Arg Ala Ala Tyr Pro Gln Val
                 485                 490                 495    
 Arg Cys Tyr Ala Phe Ser Pro Pro Arg Gly Leu Trp Ser Lys Ala Leu
             500                 505                 510        
 Gln Glu Tyr Ser Gln Ser Phe Ile Val Ser Leu Val Leu Gly Lys Asp
         515                 520                 525            
 Val Ile Pro Arg Leu Ser Val Thr Asn Leu Glu Asp Leu Lys Arg Arg
     530                 535                 540                
 Ile Leu Arg Val Val Ala His Cys Asn Lys Pro Lys Tyr Lys Ile Leu
 545                 550                 555                 560
 Leu His Gly Leu Trp Tyr Glu Leu Phe Gly Gly Asn Pro Asn Asn Leu
                 565                 570                 575    
 Pro Thr Glu Leu Asp Gly Gly Asp Gln Glu Val Leu Thr Gln Pro Leu
             580                 585                 590        
 Leu Gly Glu Gln Ser Leu Leu Thr Arg Trp Ser Pro Ala Tyr Ser Phe
         595                 600                 605            
 Ser Ser Asp Ser Pro Leu Asp Ser Ser Pro Lys Tyr Pro Pro Leu Tyr
     610                 615                 620                
 Pro Pro Gly Arg Ile Ile His Leu Gln Glu Glu Gly Ala Ser Gly Arg
 625                 630                 635                 640
 Phe Gly Cys Cys Ser Ala Ala His Tyr Ser Ala Lys Trp Ser His Glu
                 645                 650                 655    
 Ala Glu Phe Ser Lys Ile Leu Ile Gly Pro Lys Met Leu Thr Asp His
             660                 665                 670        
 Met Pro Asp Ile Leu Met Arg Ala Leu Asp Ser Val Val Ser Asp Arg
         675                 680                 685            
 Ala Ala Cys Val Ser Cys Pro Ala Gln Gly Val Ser Ser Val Asp Val
     690                 695                 700                
 Ala
 705



      <210> 1974
      <211> 184
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(184)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1974
 Glu Val His Gln Gly Thr Glu Val Arg Asp Ser Glu Val Arg Arg Arg
   1               5                  10                  15    
 Pro Gln Ala Arg Gly Pro Leu Met Pro Ala Glu Arg Ala Gly Arg Gln
              20                  25                  30        
 Arg Trp Leu Val Pro Ala Leu Gln Pro Arg Arg Gly Gly Leu Arg Arg
          35                  40                  45            
 Xaa Arg Gly Ala Val Arg Gln His Gly Ala His Pro His Gly Leu Leu
      50                  55                  60                
 Leu Gln Asp Gln Lys Ile Pro Ala Leu Pro Gly Arg Lys Gln Ala Gly
  65                  70                  75                  80
 Ser Leu His Ala Pro Gly Thr Glu Gly Glu Pro Asp His Gly Gly Asp
                  85                  90                  95    
 Pro Val Leu Asp Ala Gly Ile Gln His His Arg Gln Gln Arg His Pro
             100                 105                 110        
 Thr Ala Asp His Leu Asn Pro Gly Glu His Arg Arg Gly Glu Ala His
         115                 120                 125            
 Val Arg Ala Ala Val Xaa Pro Ala Ala Gly Ala Glu Gly Ala Ala Lys
     130                 135                 140                
 Glu Arg Arg Ala His Gln Ala Asn Thr Ala Leu Gln Val His Arg Arg
 145                 150                 155                 160
 Xaa Leu Gly Ser Phe Ala Glu Leu Arg Leu Leu Arg Lys Pro Gly Arg
                 165                 170                 175    
 Thr Ser Val Trp Pro Ser Pro Met
             180                



      <210> 1975
      <211> 34
      <212> PRT
      <213> Homo sapiens


      <400> 1975
 Pro Leu Ala Leu Cys Leu Ala Pro Ala Ala Ser Leu His Glu Leu Cys
   1               5                  10                  15    
 Ala Ala Lys Val Ser Glu Val Leu His Asn Arg Val His Arg Thr Glu
              20                  25                  30        
 Glu Val
        



      <210> 1976
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 1976
 Ala Phe Tyr Asn Ala Asn Ser Cys Leu Asn Val Phe Cys Phe Cys Phe
   1               5                  10                  15    
 Cys Phe Trp Arg Gln Ser Arg Cys Ile Ser Gln Ala Gly Val Gln Trp
              20                  25                  30        
 Cys Asp Leu Ser Ser Leu Gln Pro Pro Leu Pro Arg Phe Lys Arg Phe
          35                  40                  45            
 Ser Tyr Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg His Ala Pro Pro
      50                  55                  60                
 Cys Pro Ala Asn Phe Cys Ile Leu Val Glu Thr Gly Leu Cys His Ile
  65                  70                  75                  80
 Gly His Ala Cys Leu Glu Leu Leu Thr Ser Gly Asp Pro Pro Ala Leu
                  85                  90                  95    
 Ala Ser Gln Ser Ala Gly Ile Thr Gly Met Ser His Ser Thr Gln Pro
             100                 105                 110        
 Cys Ile Ala Val Ser
         115        



      <210> 1977
      <211> 483
      <212> PRT
      <213> Homo sapiens


      <400> 1977
 Asp Asp Phe Val Gly Val Leu Ser Ala Thr Ala Gln Val Cys Thr Met
   1               5                  10                  15    
 Ala Ala Arg Leu Val Ser Arg Cys Gly Ala Val Arg Ala Ala Pro His
              20                  25                  30        
 Ser Gly Pro Leu Ala Val Leu Ala Gln Val Val Arg Arg Ser Thr Asp
          35                  40                  45            
 Thr Val Tyr Asp Val Val Val Ser Gly Gly Gly Leu Val Gly Ala Ala
      50                  55                  60                
 Met Ala Cys Ala Leu Gly Tyr Asp Ile His Phe His Asp Lys Lys Ile
  65                  70                  75                  80
 Leu Leu Leu Glu Ala Gly Pro Lys Lys Val Leu Glu Lys Leu Ser Glu
                  85                  90                  95    
 Thr Tyr Ser Asn Arg Val Ser Ser Ile Ser Pro Gly Ser Ala Thr Leu
             100                 105                 110        
 Leu Ser Ser Phe Gly Ala Trp Asp His Ile Cys Asn Met Arg Tyr Arg
         115                 120                 125            
 Ala Phe Arg Arg Met Gln Val Trp Asp Ala Cys Ser Glu Ala Leu Ile
     130                 135                 140                
 Met Phe Asp Lys Asp Asn Leu Asp Asp Met Gly Tyr Ile Leu Glu Asn
 145                 150                 155                 160
 Asp Val Ile Met His Ala Phe Thr Lys Gln Leu Glu Ala Val Ser Asp
                 165                 170                 175    
 Arg Val Thr Val Leu Tyr Arg Ser Lys Ala Ile Arg Tyr Thr Trp Pro
             180                 185                 190        
 Cys Pro Phe Pro Met Ala Asp Ser Ser Pro Trp Val His Ile Thr Leu
         195                 200                 205            
 Gly Asp Gly Ser Thr Phe Gln Thr Lys Leu Leu Ile Gly Ala Asp Gly
     210                 215                 220                
 His Asn Ser Gly Val Arg Gln Ala Val Gly Ile Gln Asn Val Ser Trp
 225                 230                 235                 240
 Asn Tyr Asp Gln Ser Ala Val Val Ala Thr Leu His Leu Ser Glu Ala
                 245                 250                 255    
 Thr Glu Asn Asn Val Ala Trp Gln Arg Phe Leu Pro Ser Gly Pro Ile
             260                 265                 270        
 Ala Leu Leu Pro Leu Ser Asp Thr Leu Ser Ser Leu Val Trp Ser Thr
         275                 280                 285            
 Ser His Glu His Ala Ala Glu Leu Val Ser Met Asp Glu Glu Lys Phe
     290                 295                 300                
 Val Asp Ala Val Asn Ser Ala Phe Trp Ser Asp Ala Asp His Thr Asp
 305                 310                 315                 320
 Phe Ile Asp Thr Ala Gly Ala Met Leu Gln Tyr Ala Val Ser Leu Leu
                 325                 330                 335    
 Lys Pro Thr Lys Val Ser Ala Arg Gln Leu Pro Pro Ser Val Ala Arg
             340                 345                 350        
 Val Asp Ala Lys Ser Arg Val Leu Phe Pro Leu Gly Leu Gly His Ala
         355                 360                 365            
 Ala Glu Tyr Val Arg Pro Arg Val Ala Leu Ile Gly Asp Ala Ala His
     370                 375                 380                
 Arg Val His Pro Leu Ala Gly Gln Gly Val Asn Met Gly Phe Gly Asp
 385                 390                 395                 400
 Ile Ser Ser Leu Ala His His Leu Ser Thr Ala Ala Phe Asn Gly Lys
                 405                 410                 415    
 Asp Leu Gly Ser Met Ser His Leu Thr Gly Tyr Glu Thr Glu Arg Gln
             420                 425                 430        
 Arg His Asn Thr Ala Leu Leu Ala Ala Thr Asp Leu Leu Lys Arg Leu
         435                 440                 445            
 Tyr Ser Thr Ser Ala Ser Pro Leu Val Leu Leu Arg Thr Trp Gly Leu
     450                 455                 460                
 Gln Ala Thr Asn Ala Val Ser Pro Leu Lys Glu Gln Ile Met Ala Phe
 465                 470                 475                 480
 Ala Ser Lys
            



      <210> 1978
      <211> 98
      <212> PRT
      <213> Homo sapiens


      <400> 1978
 Leu Lys Asp Ser Leu Leu Arg Phe Phe Phe Phe Glu Met Glu Ser Cys
   1               5                  10                  15    
 Ser Val Thr Arg Leu Glu Cys Ser Gly Val Ile Ser Ala His Arg Asn
              20                  25                  30        
 Leu Arg Leu Pro Gly Ser Ser Asn Ser Pro Thr Ser Ala Ser Gln Val
          35                  40                  45            
 Ala Gly Thr Thr Gly Met His Pro His Thr Gln Leu Ile Phe Val Phe
      50                  55                  60                
 Ser Ala Glu Thr Gly Phe Pro His Ala Gly Gln Asp Gly Leu Asp Leu
  65                  70                  75                  80
 Leu Asn Leu Val Ile Ser Pro Pro Trp Pro Pro Lys Val Leu Gly Leu
                  85                  90                  95    
 Gln Ala
        



      <210> 1979
      <211> 66
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(66)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1979
 Ser Ala Leu Leu Gly Leu Pro Ser Ser Trp Asp Tyr Arg Arg Pro Pro
   1               5                  10                  15    
 Pro Arg Pro Ala Asn Phe Leu Tyr Phe Xaa Xaa Arg Arg Gly Phe Thr
              20                  25                  30        
 Val Leu Ala Arg Met Val Ser Ile Cys Xaa Pro Arg Asp Pro Pro Ala
          35                  40                  45            
 Ser Ala Ser Arg Ser Ala Gly Ile Ser Gly Val Ser Arg Gly Arg Pro
      50                  55                  60                
 Pro Ser
  65    



      <210> 1980
      <211> 191
      <212> PRT
      <213> Homo sapiens


      <400> 1980
 Leu Pro Gly Ala Asp Tyr Gly Gly Gly His Leu Ser Leu Arg Leu Phe
   1               5                  10                  15    
 His Leu Leu Leu Thr Ser Ala Ala Trp Val Pro Asp Glu Ser Gln Val
              20                  25                  30        
 Thr Leu Asn Ser Ala Ile Cys Val Leu Ser Thr Val Leu Ile Met Glu
          35                  40                  45            
 Phe Pro Asp Leu Gly Lys His Cys Ser Glu Lys Thr Cys Lys Gln Leu
      50                  55                  60                
 Asp Phe Leu Pro Val Lys Cys Asp Ala Cys Lys Gln Asp Phe Cys Lys
  65                  70                  75                  80
 Asp His Phe Pro Tyr Ala Ala His Lys Cys Pro Phe Ala Phe Gln Lys
                  85                  90                  95    
 Asp Val His Val Pro Val Cys Pro Leu Cys Asn Thr Pro Ile Pro Val
             100                 105                 110        
 Lys Lys Gly Gln Ile Pro Asp Val Val Val Gly Asp His Ile Asp Arg
         115                 120                 125            
 Asp Cys Asp Ser His Pro Gly Lys Lys Lys Glu Lys Ile Phe Thr Tyr
     130                 135                 140                
 Arg Cys Ser Lys Glu Gly Cys Lys Lys Lys Glu Met Leu Gln Met Val
 145                 150                 155                 160
 Cys Ala Gln Cys His Gly Asn Phe Cys Ile Gln His Arg His Pro Leu
                 165                 170                 175    
 Asp His Ser Cys Arg His Gly Ser Arg Pro Thr Ile Lys Ala Gly
             180                 185                 190    



      <210> 1981
      <211> 44
      <212> PRT
      <213> Homo sapiens


      <400> 1981
 Asp Ser Leu Thr Arg Leu Pro Ala Leu Cys Ser Leu Gln Leu Gly Arg
   1               5                  10                  15    
 Lys Val Glu Thr Ile Thr Ile Ile Tyr Asp Cys Glu Gly Leu Gly Leu
              20                  25                  30        
 Lys His Leu Trp Lys Pro Ala Val Glu Ala Tyr Gly
          35                  40                



      <210> 1982
      <211> 307
      <212> PRT
      <213> Homo sapiens


      <400> 1982
 Ser Ile Gln Glu Lys Cys Phe Asp Ser Ser Cys Gly Arg Asn Ser Leu
   1               5                  10                  15    
 Leu Ser Phe Ser Leu Ser Tyr Lys Glu Ser His Lys Thr Phe Ile Phe
              20                  25                  30        
 Tyr Cys Trp Val Tyr Arg Leu Cys Ile Trp Ile Thr Ala Ile Trp Gln
          35                  40                  45            
 Tyr Glu Ser Leu Lys Ser Arg Val Gln Ser Tyr Phe Asp Gly Ile Lys
      50                  55                  60                
 Ala Asp Trp Leu Asp Ser Ile Arg Pro Gln Lys Glu Gly Asp Phe Arg
  65                  70                  75                  80
 Lys Glu Ile Asn Lys Trp Trp Asn Asn Leu Ser Asp Gly Gln Arg Thr
                  85                  90                  95    
 Val Thr Gly Ile Ile Ala Ala Asn Val Leu Val Phe Cys Leu Trp Arg
             100                 105                 110        
 Val Pro Ser Leu Gln Arg Thr Met Ile Arg Tyr Phe Thr Ser Asn Pro
         115                 120                 125            
 Ala Ser Lys Val Leu Cys Ser Pro Met Leu Leu Ser Thr Phe Ser His
     130                 135                 140                
 Phe Ser Leu Phe His Met Ala Ala Asn Met Tyr Val Leu Trp Ser Phe
 145                 150                 155                 160
 Ser Ser Ser Ile Val Asn Ile Leu Gly Gln Glu Gln Phe Met Ala Val
                 165                 170                 175    
 Tyr Leu Ser Ala Gly Val Ile Ser Asn Phe Val Ser Tyr Leu Gly Lys
             180                 185                 190        
 Val Ala Thr Gly Arg Tyr Gly Pro Ser Leu Gly Ala Ser Gly Ala Ile
         195                 200                 205            
 Met Thr Val Leu Ala Ala Val Cys Thr Lys Ile Pro Glu Gly Arg Leu
     210                 215                 220                
 Ala Ile Ile Phe Leu Pro Met Phe Thr Phe Thr Ala Gly Asn Ala Leu
 225                 230                 235                 240
 Lys Ala Ile Ile Ala Met Asp Thr Ala Gly Met Ile Leu Gly Trp Lys
                 245                 250                 255    
 Phe Phe Asp His Ala Ala His Leu Gly Gly Ala Leu Phe Gly Ile Trp
             260                 265                 270        
 Tyr Val Thr Tyr Gly His Glu Leu Ile Trp Lys Asn Arg Glu Pro Leu
         275                 280                 285            
 Val Lys Ile Trp His Glu Ile Arg Thr Asn Gly Pro Lys Lys Gly Gly
     290                 295                 300                
 Gly Ser Lys
 305        



      <210> 1983
      <211> 34
      <212> PRT
      <213> Homo sapiens


      <400> 1983
 Arg Ala Phe Ala Glu Ala Met Arg Gly Tyr His Gly Asp Arg Gly Ser
   1               5                  10                  15    
 His Pro Arg Pro Ala Arg Phe Ala Asp Gln Gln His Met Asp Val Gly
              20                  25                  30        
 Pro Ala
        



      <210> 1984
      <211> 458
      <212> PRT
      <213> Homo sapiens


      <400> 1984
 Met Ala Trp Ala Ser Arg Leu Gly Leu Leu Leu Ala Leu Leu Leu Pro
   1               5                  10                  15    
 Val Val Gly Ala Ser Thr Pro Gly Thr Val Val Arg Leu Asn Lys Ala
              20                  25                  30        
 Ala Leu Ser Tyr Val Ser Glu Ile Gly Lys Ala Pro Leu Gln Arg Ala
          35                  40                  45            
 Leu Gln Val Thr Val Pro His Phe Leu Asp Trp Ser Gly Glu Ala Leu
      50                  55                  60                
 Gln Pro Thr Arg Ile Arg Ile Leu Asn Val His Val Pro Arg Leu His
  65                  70                  75                  80
 Leu Lys Phe Ile Ala Gly Phe Gly Val Arg Leu Leu Ala Ala Ala Asn
                  85                  90                  95    
 Phe Thr Phe Lys Val Phe Arg Ala Pro Glu Pro Leu Glu Leu Thr Leu
             100                 105                 110        
 Pro Val Glu Leu Leu Ala Asp Thr Arg Val Thr Gln Ser Ser Ile Arg
         115                 120                 125            
 Thr Pro Val Val Ser Ile Ser Ala Cys Ser Leu Phe Ser Gly His Ala
     130                 135                 140                
 Asn Glu Phe Asp Gly Ser Asn Ser Thr Ser His Ala Leu Leu Val Leu
 145                 150                 155                 160
 Val Gln Lys His Ile Lys Ala Val Leu Ser Asn Lys Leu Cys Leu Ser
                 165                 170                 175    
 Ile Ser Asn Leu Val Gln Gly Val Asn Val His Leu Gly Thr Leu Ile
             180                 185                 190        
 Gly Leu Asn Pro Val Gly Pro Glu Ser Gln Ile Arg Tyr Ser Met Val
         195                 200                 205            
 Ser Val Pro Thr Val Thr Ser Asp Tyr Ile Ser Leu Glu Val Asn Ala
     210                 215                 220                
 Val Leu Phe Leu Leu Gly Lys Pro Ile Ile Leu Pro Thr Asp Ala Thr
 225                 230                 235                 240
 Pro Phe Val Leu Pro Arg His Val Gly Thr Glu Gly Ser Met Ala Thr
                 245                 250                 255    
 Val Gly Leu Ser Gln Gln Leu Phe Asp Ser Ala Leu Leu Leu Leu Gln
             260                 265                 270        
 Lys Ala Gly Ala Leu Asn Leu Asp Ile Thr Gly Gln Leu Arg Ser Asp
         275                 280                 285            
 Asp Asn Leu Leu Asn Thr Ser Ala Leu Gly Arg Leu Ile Pro Glu Val
     290                 295                 300                
 Ala Arg Gln Phe Pro Glu Pro Met Pro Val Val Leu Lys Val Arg Leu
 305                 310                 315                 320
 Gly Ala Thr Pro Val Ala Met Leu His Thr Asn Asn Ala Thr Leu Arg
                 325                 330                 335    
 Leu Gln Pro Phe Val Glu Val Leu Ala Thr Ala Ser Asn Ser Ala Phe
             340                 345                 350        
 Gln Ser Leu Phe Ser Leu Asp Val Val Val Asn Leu Arg Leu Gln Leu
         355                 360                 365            
 Ser Val Ser Lys Val Lys Leu Gln Gly Thr Thr Ser Val Leu Gly Asp
     370                 375                 380                
 Val Gln Leu Thr Val Ala Ser Ser Asn Val Gly Phe Ile Asp Thr Asp
 385                 390                 395                 400
 Gln Val Arg Thr Leu Met Gly Thr Val Phe Glu Lys Pro Leu Leu Asp
                 405                 410                 415    
 His Leu Asn Ala Leu Leu Ala Met Gly Ile Ala Leu Pro Gly Val Val
             420                 425                 430        
 Asn Leu His Tyr Val Ala Pro Glu Ile Phe Val Tyr Glu Gly Tyr Val
         435                 440                 445            
 Val Ile Ser Ser Gly Leu Phe Tyr Gln Ser
     450                 455            



      <210> 1985
      <211> 122
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(122)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1985
 Gly Pro His Thr Ser Asn Arg Pro Arg Xaa Arg His Cys Thr Xaa Gly
   1               5                  10                  15    
 Pro Ser Thr Xaa Xaa Thr Xaa Ala Gly Ser Gly Tyr Ser Pro Ala His
              20                  25                  30        
 Gly Arg Ala Trp Gly Ala Pro Cys Xaa Ser Trp Xaa Arg Ser Pro Gly
          35                  40                  45            
 Pro Arg Gly Gly Arg Glu Ser Gly Thr Cys Arg Pro Ala Ala Ala Pro
      50                  55                  60                
 Ala Pro Ala Pro Ala Gly Gly Cys Arg Ala Gly Thr Gly Ala Trp Pro
  65                  70                  75                  80
 Pro Gly Ser Ala Thr Ser Pro Arg Cys Xaa Ser Pro Ala Ala Pro Arg
                  85                  90                  95    
 Gly Ala Gly Pro Gln Pro Gly Ser Gly Gly Ser His Gly Gly Thr Ala
             100                 105                 110        
 Arg Met Cys Ala Cys Lys Leu Ala Ala Ser
         115                 120        



      <210> 1986
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 1986
 Ala Gly Arg Arg Leu Thr Gln Ala Gly Thr Leu Leu Gly Thr Ala Leu
   1               5                  10                  15    
 Ala Phe Gly Thr Arg Leu Leu Val Ser Ser Asp Met Lys Ser Trp Ser
              20                  25                  30        
 Thr Val Leu Ala Val Met Gly Lys Ala Phe Ser Glu Ala Ala Phe Thr
          35                  40                  45            
 Thr Ala Tyr Leu Phe Thr Ser Glu Leu Tyr Pro Thr Val Leu Arg Gln
      50                  55                  60                
 Thr Gly Met Gly Leu Thr Ala Leu Val Gly Arg Leu Gly Gly Ser Leu
  65                  70                  75                  80
 Ala Pro Leu Ala Ala Leu Leu Asp Gly Val Trp Leu Ser Leu Pro Lys
                  85                  90                  95    
 Leu Thr Tyr Gly Gly Ile Ala Leu Leu Ala Ala Gly Thr Ala Leu Leu
             100                 105                 110        
 Leu Pro Glu Thr Arg Gln Ala Gln Leu Pro Glu Thr Ile Gln Asp Val
         115                 120                 125            
 Glu Arg Lys Ser Ala Pro Thr Ser Leu Gln Glu Glu Glu Met Pro Met
     130                 135                 140                
 Lys Gln Val Gln Asn
 145                



      <210> 1987
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 1987
 Lys Lys Val Gly Asn Tyr Tyr Thr Thr Pro Ile Tyr Arg Phe Arg Met
   1               5                  10                  15    
 Lys Cys His Leu Cys Val Asn Tyr Ile Glu Met Gln Thr Asp Pro Ala
              20                  25                  30        
 Asn Cys Asp Tyr Val Ile Val Ser Gly Ala Gln Arg Lys Glu Glu Arg
          35                  40                  45            
 Trp Asp Met Ala Asp Asn Glu Gln Val Leu Thr Thr Gly Glu Arg His
      50                  55                  60                
 Pro Leu Thr Cys Leu Gly Ala Leu Asp Pro Glu Ser Ala Leu Gly Pro
  65                  70                  75                  80
 Pro Lys Pro Ser Arg Ala Leu Ile Val Ala Glu His Glu Lys Lys Gln
                  85                  90                  95    
 Lys Leu Glu Thr Asp Ala Met Phe Arg Leu Glu His Gly Glu Ala Asp
             100                 105                 110        
 Arg Ser Thr Leu Lys Lys Ala Leu Pro Thr Leu Ser His Ile Gln Glu
         115                 120                 125            
 Ala Gln Ser Ala Trp Lys Asp Asp Phe Ala Leu Asn Ser Met Leu Arg
     130                 135                 140                
 Arg Arg Phe Arg Val Arg Gly Ala Pro Ala Arg Gly Gln Arg Gly Cys
 145                 150                 155                 160
 Met Val Asp Gln Gly Pro Gly Pro Ala Leu Pro Pro Pro His Pro Ser
                 165                 170                 175    
 Phe Glu Gln Ala Thr Cys Thr Phe
             180                



      <210> 1988
      <211> 673
      <212> PRT
      <213> Homo sapiens


      <400> 1988
 Gly Leu Pro Gly Ile Pro Gly Leu Pro Gly Phe Pro Gly Val Ala Gly
   1               5                  10                  15    
 Pro Pro Gly Ile Thr Gly Phe Pro Gly Phe Ile Gly Ser Arg Gly Asp
              20                  25                  30        
 Lys Gly Ala Pro Gly Arg Ala Gly Leu Tyr Gly Glu Ile Gly Ala Thr
          35                  40                  45            
 Gly Asp Phe Gly Asp Ile Gly Asp Thr Ile Asn Leu Pro Gly Arg Pro
      50                  55                  60                
 Gly Leu Lys Gly Glu Arg Gly Thr Thr Gly Ile Pro Gly Leu Lys Gly
  65                  70                  75                  80
 Phe Phe Gly Glu Lys Gly Thr Glu Gly Asp Ile Gly Phe Pro Gly Ile
                  85                  90                  95    
 Thr Gly Val Thr Gly Val Gln Gly Pro Pro Gly Leu Lys Gly Gln Thr
             100                 105                 110        
 Gly Phe Pro Gly Leu Thr Gly Pro Pro Gly Ser Gln Gly Glu Leu Gly
         115                 120                 125            
 Arg Ile Gly Leu Pro Gly Gly Lys Gly Asp Asp Gly Trp Pro Gly Ala
     130                 135                 140                
 Pro Gly Leu Pro Gly Phe Pro Gly Leu Arg Gly Ile Arg Gly Leu His
 145                 150                 155                 160
 Gly Leu Pro Gly Thr Lys Gly Phe Pro Gly Ser Pro Gly Ser Asp Ile
                 165                 170                 175    
 His Gly Asp Pro Gly Phe Pro Gly Pro Pro Gly Glu Arg Gly Asp Pro
             180                 185                 190        
 Gly Glu Ala Asn Thr Leu Pro Gly Pro Val Gly Val Pro Gly Gln Lys
         195                 200                 205            
 Gly Asp Gln Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Ser Pro Gly
     210                 215                 220                
 Leu Gln Gly Phe Pro Gly Ile Thr Pro Pro Ser Asn Ile Ser Gly Ala
 225                 230                 235                 240
 Pro Gly Asp Lys Gly Ala Pro Gly Ile Phe Gly Leu Lys Gly Tyr Arg
                 245                 250                 255    
 Gly Pro Pro Gly Pro Pro Gly Ser Ala Ala Leu Pro Gly Ser Lys Gly
             260                 265                 270        
 Asp Thr Gly Asn Pro Gly Ala Pro Gly Thr Pro Gly Thr Lys Gly Trp
         275                 280                 285            
 Ala Gly Asp Ser Gly Pro Gln Gly Arg Pro Gly Val Phe Gly Leu Pro
     290                 295                 300                
 Gly Glu Lys Gly Pro Arg Gly Glu Gln Gly Phe Met Gly Asn Thr Gly
 305                 310                 315                 320
 Pro Thr Gly Ala Val Gly Asp Arg Gly Pro Lys Gly Pro Lys Gly Asp
                 325                 330                 335    
 Pro Gly Phe Pro Gly Ala Pro Gly Thr Val Gly Ala Pro Gly Ile Ala
             340                 345                 350        
 Gly Ile Pro Gln Lys Ile Ala Val Gln Pro Gly Thr Val Gly Pro Gln
         355                 360                 365            
 Gly Arg Arg Gly Pro Pro Gly Ala Pro Gly Glu Met Gly Pro Gln Gly
     370                 375                 380                
 Pro Pro Gly Glu Pro Gly Phe Arg Gly Ala Pro Gly Lys Ala Gly Pro
 385                 390                 395                 400
 Gln Gly Arg Gly Gly Val Ser Ala Val Pro Gly Phe Arg Gly Asp Glu
                 405                 410                 415    
 Gly Pro Ile Gly His Gln Gly Pro Ile Gly Gln Glu Gly Ala Pro Gly
             420                 425                 430        
 Arg Pro Gly Ser Pro Gly Leu Pro Gly Met Pro Gly Arg Ser Val Ser
         435                 440                 445            
 Ile Gly Tyr Leu Leu Val Lys His Ser Gln Thr Asp Gln Glu Pro Met
     450                 455                 460                
 Cys Pro Val Gly Met Asn Lys Leu Trp Ser Gly Tyr Ser Leu Leu Tyr
 465                 470                 475                 480
 Phe Glu Gly Gln Glu Lys Ala His Asn Gln Asp Leu Gly Leu Ala Gly
                 485                 490                 495    
 Ser Cys Leu Ala Arg Phe Ser Thr Met Pro Phe Leu Tyr Cys Asn Pro
             500                 505                 510        
 Gly Asp Val Cys Tyr Tyr Ala Ser Arg Asn Asp Lys Ser Tyr Trp Leu
         515                 520                 525            
 Ser Thr Thr Ala Pro Leu Pro Met Met Pro Val Ala Glu Asp Glu Ile
     530                 535                 540                
 Lys Pro Tyr Ile Ser Arg Cys Ser Val Cys Glu Ala Pro Ala Ile Ala
 545                 550                 555                 560
 Ile Ala Val His Ser Gln Asp Val Ser Ile Pro His Cys Pro Ala Gly
                 565                 570                 575    
 Trp Arg Ser Leu Trp Ile Gly Tyr Ser Phe Leu Met His Thr Ala Ala
             580                 585                 590        
 Gly Asp Glu Gly Gly Gly Gln Ser Leu Val Ser Pro Gly Ser Cys Leu
         595                 600                 605            
 Glu Asp Phe Arg Ala Thr Pro Phe Ile Glu Cys Asn Gly Gly Arg Gly
     610                 615                 620                
 Thr Cys His Tyr Tyr Ala Asn Lys Tyr Ser Phe Trp Leu Thr Thr Ile
 625                 630                 635                 640
 Pro Glu Gln Ser Phe Gln Gly Ser Pro Ser Ala Asp Thr Leu Lys Ala
                 645                 650                 655    
 Gly Leu Ile Arg Thr His Ile Ser Arg Cys Gln Val Cys Met Lys Asn
             660                 665                 670        
 Leu
    



      <210> 1989
      <211> 259
      <212> PRT
      <213> Homo sapiens


      <400> 1989
 Leu Ile Tyr Asn Glu Asp Met Ile Cys Trp Ile Glu Ser Arg Glu Ser
   1               5                  10                  15    
 Ser Asn Gln Leu Lys Cys Ile Gln Ile Thr Lys Ala Gly Gly Leu Thr
              20                  25                  30        
 Asp Glu Trp Thr Ile Asn Ile Leu Gln Ser Phe His Asn Val Gln Gln
          35                  40                  45            
 Met Ala Ile Asp Trp Leu Thr Arg Asn Leu Tyr Phe Val Asp His Val
      50                  55                  60                
 Gly Asp Arg Ile Phe Val Cys Asn Ser Asn Gly Ser Val Cys Val Thr
  65                  70                  75                  80
 Leu Ile Asp Leu Glu Leu His Asn Pro Lys Ala Ile Ala Val Asp Pro
                  85                  90                  95    
 Ile Ala Gly Lys Leu Phe Phe Thr Asp Tyr Gly Asn Val Ala Lys Val
             100                 105                 110        
 Glu Arg Cys Asp Met Asp Gly Met Asn Arg Thr Arg Ile Ile Asp Ser
         115                 120                 125            
 Lys Thr Glu Gln Pro Ala Ala Leu Ala Leu Asp Leu Val Asn Lys Leu
     130                 135                 140                
 Val Tyr Trp Val Asp Leu Tyr Leu Asp Tyr Val Gly Val Val Asp Tyr
 145                 150                 155                 160
 Gln Gly Lys Asn Arg His Ala Val Ile Gln Gly Arg Gln Val Arg His
                 165                 170                 175    
 Leu Tyr Gly Ile Thr Val Phe Glu Asp Tyr Leu Tyr Ala Thr Asn Ser
             180                 185                 190        
 Asp Ser Tyr Asn Ile Val Arg Ile Ser Arg Phe Asn Gly Thr Asp Ile
         195                 200                 205            
 His Ser Leu Ile Lys Ile Glu Asn Ala Trp Gly Ile Arg Ile Tyr Gln
     210                 215                 220                
 Lys Arg Thr Gln Pro Thr Val Arg Ser His Ala Cys Glu Val Asp Pro
 225                 230                 235                 240
 Tyr Gly Met Pro Gly Gly Cys Ser His Ile Cys Leu Leu Ser Ser Ser
                 245                 250                 255    
 Tyr Thr Lys
            



      <210> 1990
      <211> 259
      <212> PRT
      <213> Homo sapiens


      <400> 1990
 Leu Ile Tyr Asn Glu Asp Met Ile Cys Trp Ile Glu Ser Arg Glu Ser
   1               5                  10                  15    
 Ser Asn Gln Leu Lys Cys Ile Gln Ile Thr Lys Ala Gly Gly Leu Thr
              20                  25                  30        
 Asp Glu Trp Thr Ile Asn Ile Leu Gln Ser Phe His Asn Val Gln Gln
          35                  40                  45            
 Met Ala Ile Asp Trp Leu Thr Arg Asn Leu Tyr Phe Val Asp His Val
      50                  55                  60                
 Gly Asp Arg Ile Phe Val Cys Asn Ser Asn Gly Ser Val Cys Val Thr
  65                  70                  75                  80
 Leu Ile Asp Leu Glu Leu His Asn Pro Lys Ala Ile Ala Val Asp Pro
                  85                  90                  95    
 Ile Ala Gly Lys Leu Phe Phe Thr Asp Tyr Gly Asn Val Ala Lys Val
             100                 105                 110        
 Glu Arg Cys Asp Met Asp Gly Met Asn Arg Thr Arg Ile Ile Asp Ser
         115                 120                 125            
 Lys Thr Glu Gln Pro Ala Ala Leu Ala Leu Asp Leu Val Asn Lys Leu
     130                 135                 140                
 Val Tyr Trp Val Asp Leu Tyr Leu Asp Tyr Val Gly Val Val Asp Tyr
 145                 150                 155                 160
 Gln Gly Lys Asn Arg His Ala Val Ile Gln Gly Arg Gln Val Arg His
                 165                 170                 175    
 Leu Tyr Gly Ile Thr Val Phe Glu Asp Tyr Leu Tyr Ala Thr Asn Ser
             180                 185                 190        
 Asp Ser Tyr Asn Ile Val Arg Ile Ser Arg Phe Asn Gly Thr Asp Ile
         195                 200                 205            
 His Ser Leu Ile Lys Ile Glu Asn Ala Trp Gly Ile Arg Ile Tyr Gln
     210                 215                 220                
 Lys Arg Thr Gln Pro Thr Val Arg Ser His Ala Cys Glu Val Asp Pro
 225                 230                 235                 240
 Tyr Gly Met Pro Gly Gly Cys Ser His Ile Cys Leu Leu Ser Ser Ser
                 245                 250                 255    
 Tyr Thr Lys
            



      <210> 1991
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 1991
 Leu Pro Phe Leu Ser Phe Phe Leu Ser Phe Phe Leu Phe Phe Leu Arg
   1               5                  10                  15    
 Trp Ser Phe Ala Leu Ile Ala Gln Ala Gly Val Gln Trp Cys Asn Phe
              20                  25                  30        
 Gly Ser Pro Gln Pro Pro Pro Pro Gly Phe Lys Arg Phe Ser Cys Leu
          35                  40                  45            
 Ser Leu Leu Ser Ser Trp Asp Tyr Arg His Thr Pro Pro Cys Leu Ala
      50                  55                  60                
 Asn Ser Val Phe Leu Val Asp Thr Gly Phe Leu His Val Gly Gln Ala
  65                  70                  75                  80
 Gly Leu Glu Leu Pro Thr Ser Gly Asp Pro Pro Thr Ser Ala Ser Gln
                  85                  90                  95    
 Ser Ala Gly Ile Thr Ser Val Ser His Cys Ala Gln Pro Val Thr Ala
             100                 105                 110        
 Ile Ser Lys Glu Glu Arg Glu Gln Ala Glu Gly Pro Asp Ser Gln Gly
         115                 120                 125            
 Thr Gly Ser Ser Ala Gly Gln
     130                 135



      <210> 1992
      <211> 220
      <212> PRT
      <213> Homo sapiens


      <400> 1992
 Gly Phe His Pro Asn Thr Thr His Tyr Arg Ala Arg Ala Ala Ala Arg
   1               5                  10                  15    
 Ala Gly Ala Gly Ser Phe Val Gly Glu Val Ser Ala Val Asp Lys Asp
              20                  25                  30        
 Phe Gly Pro Asn Gly Glu Val Arg Tyr Ser Phe Glu Met Val Gln Pro
          35                  40                  45            
 Asp Phe Glu Leu His Ala Ile Ser Gly Glu Ile Thr Asn Thr His Gln
      50                  55                  60                
 Phe Asp Arg Glu Ser Leu Met Arg Arg Arg Gly Thr Ala Val Phe Ser
  65                  70                  75                  80
 Phe Thr Val Ile Ala Thr Asp Gln Gly Ile Pro Gln Pro Leu Lys Asp
                  85                  90                  95    
 Gln Ala Thr Val His Val Tyr Met Lys Asp Ile Asn Asp Asn Ala Pro
             100                 105                 110        
 Lys Phe Leu Lys Asp Phe Tyr Gln Ala Thr Ile Ser Glu Ser Ala Ala
         115                 120                 125            
 Asn Leu Thr Gln Val Leu Arg Val Ser Ala Ser Asp Val Asp Glu Gly
     130                 135                 140                
 Asn Asn Gly Leu Ile His Tyr Ser Ile Ile Lys Gly Asn Glu Glu Arg
 145                 150                 155                 160
 Gln Phe Ala Ile Asp Ser Thr Ser Gly Gln Val Thr Leu Ile Gly Lys
                 165                 170                 175    
 Leu Asp Tyr Glu Ala Thr Pro Ala Tyr Ser Leu Val Ile Gln Ala Val
             180                 185                 190        
 Asp Ser Gly Thr Ile Pro Leu Asn Ser Thr Cys Thr Leu Asn Ile Asp
         195                 200                 205            
 Ile Leu Asp Glu Asn Asp Asn Thr Pro Phe Phe Pro
     210                 215                 220



      <210> 1993
      <211> 220
      <212> PRT
      <213> Homo sapiens


      <400> 1993
 Gly Phe His Pro Asn Thr Thr His Tyr Arg Ala Arg Ala Ala Ala Arg
   1               5                  10                  15    
 Ala Gly Ala Gly Ser Phe Val Gly Glu Val Ser Ala Val Asp Lys Asp
              20                  25                  30        
 Phe Gly Pro Asn Gly Glu Val Arg Tyr Ser Phe Glu Met Val Gln Pro
          35                  40                  45            
 Asp Phe Glu Leu His Ala Ile Ser Gly Glu Ile Thr Asn Thr His Gln
      50                  55                  60                
 Phe Asp Arg Glu Ser Leu Met Arg Arg Arg Gly Thr Ala Val Phe Ser
  65                  70                  75                  80
 Phe Thr Val Ile Ala Thr Asp Gln Gly Ile Pro Gln Pro Leu Lys Asp
                  85                  90                  95    
 Gln Ala Thr Val His Val Tyr Met Lys Asp Ile Asn Asp Asn Ala Pro
             100                 105                 110        
 Lys Phe Leu Lys Asp Phe Tyr Gln Ala Thr Ile Ser Glu Ser Ala Ala
         115                 120                 125            
 Asn Leu Thr Gln Val Leu Arg Val Ser Ala Ser Asp Val Asp Glu Gly
     130                 135                 140                
 Asn Asn Gly Leu Ile His Tyr Ser Ile Ile Lys Gly Asn Glu Glu Arg
 145                 150                 155                 160
 Gln Phe Ala Ile Asp Ser Thr Ser Gly Gln Val Thr Leu Ile Gly Lys
                 165                 170                 175    
 Leu Asp Tyr Glu Ala Thr Pro Ala Tyr Ser Leu Val Ile Gln Ala Val
             180                 185                 190        
 Asp Ser Gly Thr Ile Pro Leu Asn Ser Thr Cys Thr Leu Asn Ile Asp
         195                 200                 205            
 Ile Leu Asp Glu Asn Asp Asn Thr Pro Phe Phe Pro
     210                 215                 220



      <210> 1994
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 1994
 Gly Ser Val Ala Leu His Val Glu Lys Leu Pro Asn Glu Pro Asn Arg
   1               5                  10                  15    
 Leu Leu Ile Leu His Gly Phe Leu Asp Glu Asn Val His Phe Phe His
              20                  25                  30        
 Thr Asn Phe Leu Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln
          35                  40                  45            
 Leu Gln Val Ala Leu Pro Pro Val Ser Pro Gln Ile Tyr Pro Asn Glu
      50                  55                  60                
 Arg His Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr Glu Val Thr
  65                  70                  75                  80
 Leu Leu His Phe Leu Gln Glu Tyr Leu
                  85                



      <210> 1995
      <211> 43
      <212> PRT
      <213> Homo sapiens


      <400> 1995
 Leu Trp Thr Leu Tyr Arg His Lys Gln Gln Val Gln His Asn His Ser
   1               5                  10                  15    
 Asn Arg Leu Ser Cys Arg Pro Ser Gln Glu Asp Arg Ala Thr His Thr
              20                  25                  30        
 Ile Met Val Leu Asp Lys Glu Asn Thr Leu Ser
          35                  40            



      <210> 1996
      <211> 488
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(488)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1996
 Arg Asn Phe Arg Val Asp Asp Phe Val Ala Glu Leu Lys Leu Lys Gln
   1               5                  10                  15    
 Val Arg Trp Thr Pro Ala Ala Pro Xaa Ser Lys Glu Thr Thr Gln Gly
              20                  25                  30        
 Leu Arg Arg Leu His Val Asn Gly Arg Cys Glu Pro Lys Gly Leu Asp
          35                  40                  45            
 Pro Glu Met Gly Arg Arg Ser Ser Asp Thr Glu Glu Glu Ser Arg Ser
      50                  55                  60                
 Lys Arg Lys Lys Lys His Arg Arg Arg Ser Ser Ser Ser Ser Ser Ser
  65                  70                  75                  80
 Asp Ser Arg Thr Tyr Ser Arg Lys Lys Gly Gly Arg Lys Ser Arg Ser
                  85                  90                  95    
 Lys Ser Arg Ser Trp Ser Arg Asp Leu Gln Pro Arg Ser His Ser Tyr
             100                 105                 110        
 Asp Arg Arg Arg Arg His Arg Ser Ser Ser Ser Ser Ser Tyr Gly Ser
         115                 120                 125            
 Arg Arg Lys Arg Ser Arg Ser Arg Ser Arg Gly Arg Gly Lys Ser Tyr
     130                 135                 140                
 Arg Val Gln Arg Ser Arg Ser Lys Ser Arg Thr Arg Arg Ser Arg Ser
 145                 150                 155                 160
 Arg Pro Arg Leu Arg Ser His Ser Arg Ser Ser Glu Arg Ser Ser His
                 165                 170                 175    
 Arg Arg Thr Arg Ser Arg Ser Arg Asp Arg Glu Arg Arg Lys Gly Arg
             180                 185                 190        
 Asp Lys Glu Lys Arg Glu Lys Glu Lys Asp Lys Gly Lys Asp Lys Glu
         195                 200                 205            
 Leu His Asn Ile Lys Arg Gly Glu Ser Gly Asn Ile Lys Ala Gly Leu
     210                 215                 220                
 Glu His Ser Ala Thr Ser Xaa Thr Gly Gln Ser Gln Thr Thr Ala Gly
 225                 230                 235                 240
 Ser Xaa Ser Cys Cys Lys Ser Xaa Xaa Ser Ile Glu Ser Gln Arg Lys
                 245                 250                 255    
 Lys Xaa Gly Arg Ser Lys Glu Gln Glu Arg Arg Lys Thr Lys Pro Pro
             260                 265                 270        
 Trp Xaa Asn Lys Xaa Lys Glu Xaa Lys Phe Gly Gly Arg Arg Arg Arg
         275                 280                 285            
 Pro Asp Leu Lys Lys Arg Leu Arg Asp Cys Gly Ala Cys Thr Ser Thr
     290                 295                 300                
 Gly Gly Val Ser Pro Lys Val Trp Thr Gln Lys Trp Asp Val Gly His
 305                 310                 315                 320
 Gln Ile Leu Lys Lys Lys Ala Glu Ala Arg Glu Lys Arg Asn Thr Val
                 325                 330                 335    
 Asp Gly Pro Pro Arg Ala Val Leu Gln Ile Val Glu His Thr Ala Glu
             340                 345                 350        
 Arg Lys Glu Glu Gly Asn Gln Asp Gln Ser Gln Asp Leu Gly Pro Glu
         355                 360                 365            
 Ile Phe Ser Leu Val His Ile Leu Met Ile Glu Asp Ala Gly Ile Asp
     370                 375                 380                
 Gln Ala Val Ala Leu Leu Met Ala Pro Glu Gly Asn Glu Val Glu Val
 385                 390                 395                 400
 Val Gln Gly Val Glu Gly Asn Pro Ile Glu Phe Arg Gly Leu Gly Gln
                 405                 410                 415    
 Lys Ala Glu Gln Glu Gly Pro Gly Gln Asp Leu Val Ser Val Leu Ile
             420                 425                 430        
 Val Val Ala Val Lys Gly Pro Val Thr Glu Glu Arg Val Val Gly Leu
         435                 440                 445            
 Gly Ile Glu Asn Asp Val Arg Ala Glu Ile Lys Arg Lys Glu Lys Arg
     450                 455                 460                
 Arg Arg Ile Lys Gly Arg Thr Arg Asn Tyr Ile Thr Ser Asn Val Gly
 465                 470                 475                 480
 Asn Leu Glu Thr Ser Lys Leu Asp
                 485            



      <210> 1997
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 1997
 Val Gly Asn Phe Gln Arg Gln Leu Ala Glu Ala Lys Glu Asp Asn Cys
   1               5                  10                  15    
 Lys Val Thr Ile Met Leu Glu Asn Val Leu Ala Ser His Ser Lys Met
              20                  25                  30        
 Gln Gly Ala Leu Glu Lys Val Gln Ile Glu Leu Gly Arg Arg Asp Ser
          35                  40                  45            
 Glu Ile Ala Gly Leu Lys Lys Glu Arg Asp Leu Asn Gln Gln Arg Val
      50                  55                  60                
 Gln Lys Leu Glu Ala Glu Val Asp Gln Trp Gln Ala Arg Met Leu Val
  65                  70                  75                  80
 Met Glu Asp Gln His Asn Ser Glu Ile Glu Ser Leu Gln Lys Ala Leu
                  85                  90                  95    
 Gly Val Ala Arg Glu Asp Asn Arg Lys Leu Ala Met Ser Leu Glu Gln
             100                 105                 110        
 Ala Leu Gln Thr Asn Asn His Leu Gln Thr Lys Leu Asp His Ile Gln
         115                 120                 125            
 Glu Gln Leu Glu Ser Lys Glu Leu Glu Arg Gln Asn Leu Glu Thr Phe
     130                 135                 140                
 Lys Asp Arg Met Thr Glu Glu Ser Lys Val Glu Ala Glu Leu His Ala
 145                 150                 155                 160
 Glu
    



      <210> 1998
      <211> 477
      <212> PRT
      <213> Homo sapiens


      <400> 1998
 Pro Pro Asn Met Asp Asn Ser Met Gly Thr Glu Glu Ile Thr Val Leu
   1               5                  10                  15    
 Lys Gly Ser Ser Thr Ser Met Ala Cys Ile Thr Asp Gly Thr Pro Ala
              20                  25                  30        
 Pro Ser Met Ala Trp Leu Arg Asp Gly Gln Pro Leu Gly Leu Asp Ala
          35                  40                  45            
 His Leu Thr Val Ser Thr His Gly Met Val Leu Gln Leu Leu Lys Ala
      50                  55                  60                
 Glu Thr Glu Asp Ser Gly Lys Tyr Thr Cys Ile Ala Ser Asn Glu Ala
  65                  70                  75                  80
 Gly Glu Val Ser Lys His Phe Ile Leu Lys Val Leu Val Pro Pro Ser
                  85                  90                  95    
 Phe Gln Lys Leu Trp Glu Ile Gly Asn Met Leu Asp Thr Gly Arg Asn
             100                 105                 110        
 Gly Glu Ala Lys Asp Val Ile Ile Asn Asn Pro Ile Ser Leu Tyr Cys
         115                 120                 125            
 Glu Thr Asn Ala Ala Pro Pro Pro Thr Leu Thr Trp Tyr Lys Asp Gly
     130                 135                 140                
 His Pro Leu Thr Ser Ser Asp Lys Val Leu Ile Leu Pro Gly Gly Arg
 145                 150                 155                 160
 Val Leu Gln Ile Pro Arg Ala Lys Val Glu Asp Ala Gly Arg Tyr Thr
                 165                 170                 175    
 Cys Val Ala Val Asn Glu Ala Gly Glu Asp Ser Leu Gln Tyr Asp Val
             180                 185                 190        
 Arg Val Leu Val Pro Pro Ile Ile Lys Gly Ala Asn Ser Asp Leu Pro
         195                 200                 205            
 Glu Glu Val Thr Val Leu Val Asn Lys Ser Ala Leu Ile Glu Cys Leu
     210                 215                 220                
 Ser Ser Gly Ser Pro Ala Pro Arg Asn Ser Trp Gln Lys Asp Gly Gln
 225                 230                 235                 240
 Pro Leu Leu Glu Asp Asp His His Lys Phe Leu Ser Asn Gly Arg Ile
                 245                 250                 255    
 Leu Gln Ile Leu Asn Thr Gln Ile Thr Asp Ile Gly Arg Tyr Val Cys
             260                 265                 270        
 Val Ala Glu Asn Thr Ala Gly Ser Ala Lys Lys Tyr Phe Asn Leu Asn
         275                 280                 285            
 Val His Val Pro Pro Ser Val Ile Gly Pro Lys Ser Glu Asn Leu Thr
     290                 295                 300                
 Val Val Val Asn Asn Phe Ile Ser Leu Thr Cys Glu Val Ser Gly Phe
 305                 310                 315                 320
 Pro Pro Pro Asp Leu Ser Trp Leu Lys Asn Glu Gln Pro Ile Pro Leu
                 325                 330                 335    
 Asn Thr Asn Thr Leu Ile Ala Pro Gly Gly Arg Thr Leu Gln Ile Ile
             340                 345                 350        
 Arg Ala Lys Val Ser Asp Gly Gly Glu Tyr Thr Cys Ile Ala Ile Asn
         355                 360                 365            
 Gln Ala Gly Glu Ser Lys Lys Lys Phe Ser Leu Thr Val Tyr Val Pro
     370                 375                 380                
 Pro Ser Ile Lys Asp His Asp Ser Glu Ser Leu Ser Val Val Asn Val
 385                 390                 395                 400
 Arg Glu Gly Thr Ser Val Ser Leu Glu Cys Glu Ser Asn Ala Val Pro
                 405                 410                 415    
 Pro Pro Val Ile Thr Trp Tyr Lys Asn Gly Arg Met Ile Thr Glu Ser
             420                 425                 430        
 Thr His Val Glu Ile Leu Ala Asp Gly Gln Met Leu His Ile Lys Lys
         435                 440                 445            
 Ala Glu Val Ser Asp Thr Gly Gln Tyr Val Cys Arg Ala Ile Asn Val
     450                 455                 460                
 Ala Gly Arg Asp Asp Lys Asn Phe His Leu Asn Val Tyr
 465                 470                 475        



      <210> 1999
      <211> 444
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(444)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1999
 Arg Ser Gly Glu Gly Phe His Val Asn Ser Ser Xaa Thr Trp Val Ser
   1               5                  10                  15    
 Arg Ser Xaa Glu Met Asp Glu Thr Pro Gly Ser Glu Val Pro Gly Asp
              20                  25                  30        
 Lys Ala Ala Glu Glu Gln Gly Asp Asp Gln Asp Ser Glu Lys Ser Lys
          35                  40                  45            
 Pro Ala Gly Ser Asp Gly Glu Arg Arg Gly Val Lys Arg Gln Arg Asp
      50                  55                  60                
 Glu Lys Asp Glu His Gly Arg Ala Tyr Tyr Glu Phe Arg Glu Glu Ala
  65                  70                  75                  80
 Tyr His Ser Arg Ser Lys Ser Pro Leu Pro Pro Glu Glu Glu Ala Lys
                  85                  90                  95    
 Asp Glu Glu Glu Asp Gln Thr Leu Val Asn Leu Asp Thr Tyr Thr Ser
             100                 105                 110        
 Asp Leu His Phe Gln Val Ser Lys Asp Arg Tyr Gly Gly Gln Pro Leu
         115                 120                 125            
 Phe Ser Glu Lys Phe Pro Thr Leu Trp Ser Gly Ala Arg Ser Thr Tyr
     130                 135                 140                
 Gly Val Thr Lys Gly Lys Val Cys Phe Glu Ala Lys Val Thr Gln Asn
 145                 150                 155                 160
 Leu Pro Met Lys Glu Gly Cys Thr Glu Val Ser Leu Leu Arg Val Gly
                 165                 170                 175    
 Trp Ser Val Asp Phe Ser Arg Pro Gln Leu Gly Glu Asp Glu Phe Ser
             180                 185                 190        
 Tyr Gly Phe Asp Gly Arg Gly Leu Lys Ala Glu Asn Gly Gln Phe Glu
         195                 200                 205            
 Glu Phe Gly Gln Thr Phe Gly Glu Asn Asp Val Ile Gly Cys Phe Ala
     210                 215                 220                
 Asn Phe Glu Thr Glu Glu Val Glu Leu Ser Phe Ser Lys Asn Gly Glu
 225                 230                 235                 240
 Asp Leu Gly Val Ala Phe Trp Ile Ser Lys Asp Ser Leu Ala Asp Arg
                 245                 250                 255    
 Ala Leu Leu Pro His Val Leu Cys Lys Asn Cys Val Val Glu Leu Asn
             260                 265                 270        
 Phe Gly Gln Lys Glu Glu Pro Phe Phe Pro Pro Pro Glu Glu Phe Val
         275                 280                 285            
 Phe Ile His Ala Val Pro Val Glu Glu Arg Val Arg Thr Ala Val Pro
     290                 295                 300                
 Pro Lys Thr Ile Glu Glu Cys Glu Val Ile Leu Met Val Gly Leu Pro
 305                 310                 315                 320
 Gly Ser Gly Lys Thr Gln Trp Ala Leu Lys Tyr Ala Lys Glu Asn Pro
                 325                 330                 335    
 Glu Lys Arg Tyr Asn Val Leu Gly Ala Glu Thr Val Leu Asn Gln Met
             340                 345                 350        
 Arg Met Lys Gly Leu Glu Glu Pro Glu Met Asp Pro Lys Ser Arg Asp
         355                 360                 365            
 Leu Leu Val Gln Gln Ala Ser Gln Cys Leu Ser Lys Leu Val Gln Ile
     370                 375                 380                
 Ala Ser Arg Thr Lys Arg Asn Phe Ile Leu Asp Gln Cys Asn Val Tyr
 385                 390                 395                 400
 Asn Ser Gly Gln Arg Arg Lys Leu Leu Leu Phe Lys Thr Phe Ser Arg
                 405                 410                 415    
 Lys Val Val Val Val Val Pro Asn Glu Asp Asp Trp Lys Lys Arg Leu
             420                 425                 430        
 Glu Leu Arg Lys Glu Val Glu Gly Arg Val Phe Pro
         435                 440                



      <210> 2000
      <211> 354
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(354)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2000
 Ile Ile Phe Leu Phe Phe Xaa Pro Tyr Leu Gln Ser Val Ile Phe Leu
   1               5                  10                  15    
 Phe Val Ile Arg Gly Leu Glu Met Lys Tyr Gly Asn Glu Ile Met Asn
              20                  25                  30        
 Lys Asp Pro Val Phe Arg Ile Ser Pro Arg Ser Arg Glu Thr His Pro
          35                  40                  45            
 Asn Pro Glu Glu Pro Glu Glu Glu Asp Glu Asp Val Gln Ala Glu Arg
      50                  55                  60                
 Val Gln Ala Ala Asn Ala Leu Thr Ala Pro Asn Leu Glu Glu Glu Pro
  65                  70                  75                  80
 Val Ile Thr Ala Ser Cys Leu His Lys Glu Tyr Tyr Glu Thr Lys Lys
                  85                  90                  95    
 Ser Cys Phe Ser Thr Arg Lys Lys Lys Ile Ala Ile Arg Asn Val Ser
             100                 105                 110        
 Phe Cys Val Lys Lys Gly Glu Val Leu Gly Leu Leu Gly His Asn Gly
         115                 120                 125            
 Ala Gly Lys Ser Thr Ser Ile Lys Met Ile Thr Gly Cys Thr Val Pro
     130                 135                 140                
 Thr Ala Gly Val Val Val Leu Gln Gly Asn Arg Ala Ser Val Arg Gln
 145                 150                 155                 160
 Gln Arg Asp Asn Ser Leu Lys Phe Leu Gly Tyr Cys Pro Gln Glu Asn
                 165                 170                 175    
 Ser Leu Trp Pro Lys Leu Thr Met Lys Glu His Leu Glu Leu Tyr Ala
             180                 185                 190        
 Ala Val Lys Gly Leu Gly Lys Asp Ala Ala Leu Ser Ile Ser Xaa Leu
         195                 200                 205            
 Val Glu Ala Leu Lys Leu Gln Glu Gln Leu Lys Ala Pro Val Lys Thr
     210                 215                 220                
 Leu Ser Glu Gly Ile Lys Arg Lys Leu Cys Phe Val Leu Ser Ile Leu
 225                 230                 235                 240
 Gly Asn Pro Ser Val Val Leu Leu Asp Glu Leu Phe Thr Gly Met Asp
                 245                 250                 255    
 Pro Glu Gly Gln Gln Gln Met Trp Gln Ile Leu Gln Ala Thr Ile Lys
             260                 265                 270        
 Asn Gln Glu Arg Gly Ala Leu Leu Thr Thr His Tyr Met Ser Glu Ala
         275                 280                 285            
 Lys Ser Leu Cys Asp Arg Val Ala Ile Met Val Ser Gly Thr Leu Arg
     290                 295                 300                
 Cys Ile Gly Ser Ile Gln Gln Leu Lys Lys Phe Gly Lys Asp Tyr Leu
 305                 310                 315                 320
 Leu Glu Ile Lys Met Lys Glu Pro Thr Gln Val Glu Ala Leu His Thr
                 325                 330                 335    
 Glu Ile Leu Lys Leu Phe Pro Gln Ala Ala Trp Gln Glu Arg Tyr Ser
             340                 345                 350        
 Ser Leu
        



      <210> 2001
      <211> 847
      <212> PRT
      <213> Homo sapiens


      <400> 2001
 Thr Ile Ser Ser Ser Pro Lys Trp Arg Leu Ser Gly Trp Arg Ala Pro
   1               5                  10                  15    
 Cys Cys Trp Gly Phe Glu Val Val Ala Gly Gly Pro Gly Asp Pro Phe
              20                  25                  30        
 Pro Ala Ala Glu Ala Leu Glu Asp Glu Ser Gly Thr Leu Leu Arg Ser
          35                  40                  45            
 Gly Gly Gly Ala Gly Glu Gln Trp Gln Gln Gly Leu Arg Trp Arg Pro
      50                  55                  60                
 Arg Ser Gly Met Cys Glu Ser Tyr Ser Arg Ser Leu Leu Arg Val Ser
  65                  70                  75                  80
 Val Ala Gln Ile Cys Gln Ala Leu Gly Trp Asp Ser Val Gln Leu Ser
                  85                  90                  95    
 Ala Cys His Leu Leu Thr Asp Val Leu Gln Arg Tyr Leu Gln Gln Leu
             100                 105                 110        
 Gly Arg Gly Cys His Arg Tyr Ser Glu Leu Tyr Gly Arg Thr Asp Pro
         115                 120                 125            
 Ile Leu Asp Asp Val Gly Glu Ala Phe Gln Leu Met Gly Val Ser Leu
     130                 135                 140                
 His Glu Leu Glu Asp Tyr Ile His Asn Ile Glu Pro Val Thr Phe Pro
 145                 150                 155                 160
 His Gln Ile Pro Ser Phe Pro Val Ser Lys Asn Asn Val Leu Gln Phe
                 165                 170                 175    
 Pro Gln Pro Gly Ser Lys Asp Ala Glu Glu Arg Lys Glu Tyr Ile Pro
             180                 185                 190        
 Asp Tyr Leu Pro Pro Ile Val Ser Ser Gln Glu Glu Glu Glu Glu Glu
         195                 200                 205            
 Gln Val Pro Thr Asp Gly Gly Thr Ser Ala Glu Ala Met Gln Val Pro
     210                 215                 220                
 Leu Glu Glu Asp Asp Glu Leu Glu Glu Glu Glu Ile Ile Asn Asp Glu
 225                 230                 235                 240
 Asn Phe Leu Gly Lys Arg Pro Leu Asp Ser Pro Glu Ala Glu Glu Leu
                 245                 250                 255    
 Pro Ala Met Lys Arg Pro Arg Leu Leu Ser Thr Lys Gly Asp Thr Leu
             260                 265                 270        
 Asp Val Val Leu Leu Glu Ala Arg Glu Pro Leu Ser Ser Ile Asn Thr
         275                 280                 285            
 Gln Lys Ile Pro Pro Met Leu Ser Pro Val His Val Gln Asp Ser Thr
     290                 295                 300                
 Asp Leu Ala Pro Pro Ser Pro Glu Pro Pro Met Leu Ala Pro Val Ala
 305                 310                 315                 320
 Lys Ser Gln Met Pro Thr Ala Lys Pro Leu Glu Thr Lys Ser Phe Thr
                 325                 330                 335    
 Pro Lys Thr Lys Thr Lys Thr Ser Ser Pro Gly Gln Lys Thr Lys Ser
             340                 345                 350        
 Pro Lys Thr Ala Gln Ser Pro Ala Met Val Gly Ser Pro Ile Arg Ser
         355                 360                 365            
 Pro Lys Thr Val Ser Lys Glu Lys Lys Ser Pro Gly Arg Ser Lys Ser
     370                 375                 380                
 Pro Lys Ser Pro Lys Ser Pro Lys Val Thr Thr His Ile Pro Gln Thr
 385                 390                 395                 400
 Pro Val Arg Pro Glu Thr Pro Asn Arg Thr Pro Ser Ala Thr Leu Ser
                 405                 410                 415    
 Glu Lys Ile Ser Lys Glu Thr Ile Gln Val Lys Gln Ile Gln Thr Pro
             420                 425                 430        
 Pro Asp Ala Gly Lys Leu Asn Ser Glu Asn Gln Pro Lys Lys Ala Val
         435                 440                 445            
 Val Ala Asp Lys Thr Ile Glu Ala Ser Ile Asp Ala Val Ile Ala Arg
     450                 455                 460                
 Ala Cys Ala Glu Arg Glu Pro Asp Pro Phe Glu Phe Ser Ser Gly Ser
 465                 470                 475                 480
 Glu Ser Glu Gly Asp Ile Phe Thr Ser Pro Lys Arg Ile Ser Gly Pro
                 485                 490                 495    
 Glu Cys Thr Thr Pro Lys Ala Ser Thr Ser Ala Asn Ser Phe Thr Lys
             500                 505                 510        
 Ser Gly Ser Thr Pro Leu Pro Leu Ser Gly Gly Thr Ser Ser Ser Asp
         515                 520                 525            
 Asn Ser Trp Thr Met Asp Ala Ser Ile Asp Glu Val Val Arg Lys Ala
     530                 535                 540                
 Lys Leu Gly Thr Pro Ser Asn Met Pro Pro Asn Phe Pro Tyr Ile Ser
 545                 550                 555                 560
 Ser Pro Ser Val Ser Pro Pro Thr Pro Glu Pro Leu His Lys Val Tyr
                 565                 570                 575    
 Glu Glu Lys Thr Lys Leu Pro Ser Ser Val Glu Val Lys Lys Lys Leu
             580                 585                 590        
 Lys Lys Glu Leu Lys Thr Lys Met Lys Lys Lys Glu Lys Gln Arg Asp
         595                 600                 605            
 Arg Glu Arg Glu Lys Asp Lys Asn Lys Asp Lys Ser Lys Glu Lys Asp
     610                 615                 620                
 Lys Val Lys Glu Lys Glu Lys Asp Lys Glu Thr Gly Arg Glu Thr Lys
 625                 630                 635                 640
 Tyr Pro Trp Lys Glu Phe Leu Lys Glu Glu Glu Ala Asp Pro Tyr Lys
                 645                 650                 655    
 Phe Lys Ile Lys Glu Phe Glu Asp Val Asp Pro Lys Val Lys Leu Lys
             660                 665                 670        
 Asp Gly Leu Val Arg Lys Glu Lys Glu Lys His Lys Asp Lys Lys Lys
         675                 680                 685            
 Asp Arg Glu Lys Gly Lys Lys Asp Lys Asp Lys Arg Glu Lys Glu Lys
     690                 695                 700                
 Val Lys Asp Lys Gly Arg Glu Asp Lys Met Lys Ala Pro Ala Pro Pro
 705                 710                 715                 720
 Leu Val Leu Pro Pro Lys Glu Leu Ala Leu Pro Leu Phe Ser Pro Ala
                 725                 730                 735    
 Thr Ala Ser Arg Val Pro Ala Met Leu Pro Ser Leu Leu Pro Val Leu
             740                 745                 750        
 Pro Glu Lys Leu Phe Glu Glu Lys Glu Lys Pro Lys Glu Lys Glu Lys
         755                 760                 765            
 Lys Lys Asp Lys Lys Glu Lys Lys Lys Lys Lys Glu Lys Glu Lys Glu
     770                 775                 780                
 Lys Lys Glu Lys Glu Arg Glu Lys Glu Lys Arg Glu Arg Glu Lys Arg
 785                 790                 795                 800
 Glu Lys Glu Lys Glu Lys His Lys His Glu Lys Ile Lys Val Glu Pro
                 805                 810                 815    
 Val Ala Leu Ala Pro Ser Pro Val Ile Pro Arg Leu Thr Leu Arg Val
             820                 825                 830        
 Gly Ala Gly Pro Asp Lys Ile Arg Arg Arg Arg Ala Gly Ala His
         835                 840                 845        



      <210> 2002
      <211> 577
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(577)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2002
 Gln Asn Glu Asn Ser Val Asp Lys Trp Gly Lys Pro Leu Val Ile Asp
   1               5                  10                  15    
 Lys Leu Lys Glu Met Ala Lys Val Glu Gly Leu Trp Asn Leu Phe Leu
              20                  25                  30        
 Pro Ala Val Ser Gly Leu Ser His Val Asp Tyr Ala Leu Ile Ala Glu
          35                  40                  45            
 Glu Thr Gly Lys Cys Phe Phe Ala Pro Asp Val Phe Asn Cys Gln Ala
      50                  55                  60                
 Pro Asp Thr Gly Asn Met Glu Val Leu His Leu Tyr Gly Ser Glu Glu
  65                  70                  75                  80
 Gln Lys Lys Gln Trp Leu Glu Pro Leu Leu Gln Gly Asn Ile Thr Ser
                  85                  90                  95    
 Cys Phe Cys Met Thr Glu Pro Asp Val Ala Ser Ser Asp Ala Thr Asn
             100                 105                 110        
 Ile Glu Cys Ser Ile Gln Arg Asp Glu Asp Ser Tyr Val Ile Asn Gly
         115                 120                 125            
 Lys Lys Trp Trp Ser Ser Gly Ala Gly Asn Pro Lys Cys Lys Ile Ala
     130                 135                 140                
 Ile Val Leu Gly Arg Thr Gln Asn Thr Ser Leu Ser Arg Xaa Leu Asn
 145                 150                 155                 160
 Asn Ser Asp Xaa Glu Thr Cys Val Gly Met Ser Gln Ser Ser Ser Tyr
                 165                 170                 175    
 Leu Gly Asn Leu Leu Lys Ile His Cys Leu Asp Ser Gln Ile Ile Met
             180                 185                 190        
 Xaa Asp Met Arg Val Asn Val Ile Tyr Leu Tyr Phe Thr Ser Ile Phe
         195                 200                 205            
 Xaa Gln Val Phe Leu Glu Asn Ile Ile Gly Ser Ile Ala Glu His Ser
     210                 215                 220                
 Ser Leu Trp Asn Phe Gln Tyr Xaa Lys Val Leu Leu Asn Tyr Gln Ser
 225                 230                 235                 240
 Cys Leu Asp Xaa Ile Ile Arg Gln Ile Phe Ser Asp Leu Cys Asn Glu
                 245                 250                 255    
 Val Ile Arg Cys Leu Asp Gln Arg Gln Xaa Ser Xaa Asn Val Xaa Leu
             260                 265                 270        
 Tyr Ile Xaa Val Pro Ser Tyr His Cys Xaa Ala Val Arg Ser Phe Asn
         275                 280                 285            
 Gln Thr Thr His Leu Phe Ser Asn His Cys Phe Cys Ser Arg Ser Gln
     290                 295                 300                
 Pro Ala Ser Asp Tyr Val Gly Val Arg Leu Leu His Ser Ser His Ser
 305                 310                 315                 320
 Ser His His Cys Leu His Asp Tyr Met Lys Thr Ser Lys Arg Gln Leu
                 325                 330                 335    
 Gly Phe Cys Leu Leu Ser Val Leu Phe Phe Phe Leu Ala Asn Phe Phe
             340                 345                 350        
 Xaa Tyr Asn Phe Ser Phe Asp Xaa His Lys Gln His Ser Met Ile Leu
         355                 360                 365            
 Val Pro Met Asn Thr Pro Gly Val Lys Ile Ile Arg Pro Leu Ser Val
     370                 375                 380                
 Phe Gly Tyr Thr Asp Asn Phe His Gly Gly His Phe Glu Ile His Phe
 385                 390                 395                 400
 Asn Gln Val Arg Val Pro Ala Thr Asn Leu Ile Leu Gly Glu Gly Arg
                 405                 410                 415    
 Gly Phe Glu Ile Ser Gln Gly Arg Leu Gly Pro Gly Arg Ile His His
             420                 425                 430        
 Cys Met Arg Thr Val Gly Leu Ala Glu Arg Ala Leu Gln Ile Met Cys
         435                 440                 445            
 Glu Arg Ala Thr Gln Arg Ile Ala Phe Lys Lys Lys Leu Tyr Ala His
     450                 455                 460                
 Glu Val Val Ala His Trp Ile Ala Glu Ser Arg Ile Ala Ile Glu Lys
 465                 470                 475                 480
 Ile Arg Leu Leu Thr Leu Lys Ala Ala His Ser Met Asp Thr Leu Gly
                 485                 490                 495    
 Ser Ala Gly Ala Lys Lys Glu Ile Ala Met Ile Lys Val Ala Ala Pro
             500                 505                 510        
 Arg Ala Val Ser Lys Ile Val Asp Trp Ala Ile Gln Val Cys Gly Gly
         515                 520                 525            
 Ala Gly Val Ser Gln Asp Tyr Pro Leu Ala Asn Met Tyr Ala Ile Thr
     530                 535                 540                
 Arg Val Leu Arg Leu Ala Asp Gly Pro Asp Glu Val His Leu Ser Ala
 545                 550                 555                 560
 Ile Ala Thr Met Glu Leu Arg Asp Gln Ala Lys Arg Leu Thr Ala Lys
                 565                 570                 575    
 Ile
    



      <210> 2003
      <211> 573
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(573)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2003
 Arg Arg Pro Pro Glu Gly Gly Ser Gly Gly Gly Arg Arg Thr Arg Ala
   1               5                  10                  15    
 Arg Met Pro Leu Pro Trp Ser Leu Ala Leu Pro Leu Leu Leu Ser Trp
              20                  25                  30        
 Val Ala Gly Gly Phe Gly Asn Ala Ala Ser Ala Arg His His Gly Leu
          35                  40                  45            
 Leu Ala Ser Ala Arg Gln Pro Gly Val Cys His Tyr Gly Thr Lys Leu
      50                  55                  60                
 Ala Cys Cys Tyr Gly Trp Arg Arg Asn Ser Lys Gly Val Cys Glu Ala
  65                  70                  75                  80
 Thr Cys Glu Pro Gly Cys Lys Phe Gly Glu Cys Val Gly Pro Asn Lys
                  85                  90                  95    
 Cys Arg Cys Phe Pro Gly Tyr Thr Gly Lys Thr Cys Ser Gln Asp Val
             100                 105                 110        
 Asn Glu Cys Gly Met Lys Pro Arg Pro Cys Gln His Arg Cys Val Asn
         115                 120                 125            
 Thr His Gly Ser Tyr Lys Cys Phe Cys Leu Ser Gly His Met Leu Met
     130                 135                 140                
 Pro Asp Ala Thr Cys Val Asn Ser Arg Thr Cys Ala Met Ile Asn Cys
 145                 150                 155                 160
 Gln Tyr Ser Cys Glu Asp Thr Glu Glu Gly Pro Gln Cys Leu Cys Pro
                 165                 170                 175    
 Ser Ser Gly Leu Arg Leu Ala Pro Asn Gly Arg Asp Cys Leu Asp Ile
             180                 185                 190        
 Asp Glu Cys Ala Ser Gly Lys Val Ile Cys Pro Tyr Asn Arg Arg Cys
         195                 200                 205            
 Val Asn Thr Phe Gly Ser Tyr Tyr Cys Lys Cys His Ile Gly Phe Glu
     210                 215                 220                
 Leu Gln Tyr Ile Ser Gly Arg Tyr Asp Cys Ile Asp Ile Asn Glu Cys
 225                 230                 235                 240
 Thr Met Asp Ser His Thr Cys Ser His His Ala Asn Cys Phe Asn Thr
                 245                 250                 255    
 Gln Gly Ser Phe Lys Cys Lys Cys Lys Gln Gly Tyr Lys Gly Asn Gly
             260                 265                 270        
 Leu Arg Cys Ser Ala Ile Pro Glu Asn Ser Val Lys Glu Val Leu Arg
         275                 280                 285            
 Ala Pro Gly Thr Ile Lys Asp Arg Ile Lys Lys Leu Leu Ala His Lys
     290                 295                 300                
 Asn Ser Met Lys Lys Lys Ala Lys Ile Lys Asn Val Thr Pro Glu Pro
 305                 310                 315                 320
 Thr Arg Thr Pro Thr Pro Lys Val Asn Leu Gln Pro Phe Asn Tyr Glu
                 325                 330                 335    
 Glu Ile Val Ser Arg Gly Gly Asn Ser His Gly Gly Lys Lys Gly Asn
             340                 345                 350        
 Glu Glu Lys Met Lys Glu Gly Leu Glu Asp Glu Lys Arg Glu Glu Lys
         355                 360                 365            
 Ala Leu Lys Asp Xaa His Arg Arg Glu Arg Pro Phe Arg Gly Asp Val
     370                 375                 380                
 Phe Phe Pro Lys Val Asn Glu Ala Gly Glu Phe Gly Leu Ile Leu Val
 385                 390                 395                 400
 Gln Arg Lys Ala Leu Thr Ser Lys Leu Glu His Lys Ala Asp Leu Asn
                 405                 410                 415    
 Ile Ser Val Asp Cys Ser Phe Asn His Gly Ile Cys Asp Trp Lys Gln
             420                 425                 430        
 Asp Arg Glu Asp Asp Phe Asp Trp Asn Pro Ala Asp Arg Asp Asn Ala
         435                 440                 445            
 Ile Gly Phe Tyr Met Ala Val Pro Gly Leu Trp Gln Gly His Lys Lys
     450                 455                 460                
 Asp Ile Gly Arg Leu Lys Leu Leu Leu Pro Asp Leu Gln Pro Gln Ser
 465                 470                 475                 480
 Asn Phe Cys Leu Leu Phe Asp Tyr Arg Leu Ala Gly Asp Lys Val Gly
                 485                 490                 495    
 Lys Leu Arg Val Phe Val Lys Asn Ser Asn Asn Ala Leu Ala Trp Glu
             500                 505                 510        
 Lys Thr Thr Ser Glu Asp Glu Lys Trp Lys Thr Gly Lys Ile Gln Leu
         515                 520                 525            
 Tyr Gln Gly Thr Asp Ala Thr Lys Ser Ile Ile Phe Glu Ala Glu Arg
     530                 535                 540                
 Gly Lys Gly Lys Thr Gly Glu Ile Ala Val Asp Gly Val Leu Leu Val
 545                 550                 555                 560
 Ser Gly Leu Cys Pro Asp Ser Leu Leu Ser Val Asp Asp
                 565                 570            



      <210> 2004
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 2004
 Lys Gly Thr Lys Asn Gly Gln Phe Asn Tyr Pro Trp Asp Val Ala Val
   1               5                  10                  15    
 Asn Ser Glu Gly Lys Ile Leu Val Ser Asp Thr Arg Asn His Arg Ile
              20                  25                  30        
 Gln Leu Phe Gly Pro Asp Gly Val Phe Leu Asn Lys Tyr Gly Phe Glu
          35                  40                  45            
 Gly Ala Leu Trp Lys His Phe Asp Ser Pro Arg Gly Val Ala Phe Asn
      50                  55                  60                
 His Glu Gly His Leu Val Val Thr Asp Phe Asn Asn His Arg Leu Leu
  65                  70                  75                  80
 Val Ile His Pro Asp Cys Gln Ser Ala Arg Phe Leu Gly Ser Glu Gly
                  85                  90                  95    
 Thr Gly Asn Gly Gln Phe Leu Arg Pro Gln Gly Val Ala Val Asp Gln
             100                 105                 110        
 Glu Gly Arg Ile Ile Val Ala Asp Ser Arg Asn His Arg Val Gln Met
         115                 120                 125            
 Phe Glu Ser Asn Gly Ser Phe Leu Cys Lys Phe Gly Ala Gln Gly Ser
     130                 135                 140                
 Gly Phe Gly Gln Met Asp Arg Pro Ser Gly Ile Ala
 145                 150                 155    



      <210> 2005
      <211> 1165
      <212> PRT
      <213> Homo sapiens


      <400> 2005
 Gln Cys Gly Pro Glu Ala Ala Ser Ala Gly Ser Cys Ser Ala Glu Thr
   1               5                  10                  15    
 Pro Ser Pro Pro Pro Arg Ala Pro Gly Arg Gly Pro Ile Met Phe Ser
              20                  25                  30        
 Arg Lys Lys Arg Glu Leu Met Lys Thr Pro Ser Ile Ser Lys Lys Asn
          35                  40                  45            
 Arg Ala Gly Ser Pro Ser Pro Gln Pro Ser Gly Glu Leu Pro Arg Lys
      50                  55                  60                
 Asp Gly Ala Asp Ala Val Phe Pro Gly Pro Ser Leu Glu Pro Pro Ala
  65                  70                  75                  80
 Gly Ser Ser Gly Val Lys Ala Thr Gly Thr Leu Lys Arg Pro Thr Ser
                  85                  90                  95    
 Leu Ser Arg His Ala Ser Ala Ala Gly Phe Pro Leu Ser Gly Ala Ala
             100                 105                 110        
 Ser Trp Thr Leu Gly Arg Ser His Arg Ser Pro Leu Thr Ala Ala Ser
         115                 120                 125            
 Pro Gly Glu Leu Pro Thr Glu Gly Ala Gly Pro Asp Val Val Glu Asp
     130                 135                 140                
 Ile Ser His Leu Leu Ala Asp Val Ala Arg Phe Ala Glu Gly Leu Glu
 145                 150                 155                 160
 Lys Leu Lys Glu Cys Val Leu His Asp Asp Leu Leu Glu Ala Arg Arg
                 165                 170                 175    
 Pro Arg Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val Met His Gln
             180                 185                 190        
 Ile Ile Ser Lys Tyr Pro Leu Leu Asn Thr Val Glu Thr Leu Thr Ala
         195                 200                 205            
 Ala Gly Thr Leu Ile Ala Lys Val Lys Ala Phe His Tyr Glu Ser Asn
     210                 215                 220                
 Asn Asp Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu Thr Ile Ala
 225                 230                 235                 240
 Val Ala Phe Ser Ser Thr Val Ser Glu Phe Leu Met Gly Glu Val Asp
                 245                 250                 255    
 Ser Ser Thr Leu Leu Ala Val Pro Pro Gly Asp Ser Ser Gln Ser Met
             260                 265                 270        
 Glu Ser Leu Tyr Gly Pro Gly Ser Glu Gly Thr Pro Pro Ser Leu Glu
         275                 280                 285            
 Asp Cys Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp Val Leu Leu
     290                 295                 300                
 Gln Arg Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr Ala Lys Asn
 305                 310                 315                 320
 Met Ala Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu Lys Arg Thr
                 325                 330                 335    
 Thr Leu Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile Ala His Asn
             340                 345                 350        
 Cys Arg Gln Ser Val Met Gln Glu Pro His Met Pro Leu Leu Ser Ile
         355                 360                 365            
 Tyr Ser Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His Ser Met Val
     370                 375                 380                
 Gln Ala Val Gly Thr Leu Gln Thr Gln Thr Phe Met Gln Pro Leu Thr
 385                 390                 395                 400
 Leu Arg Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile Lys Glu Ala
                 405                 410                 415    
 Trp His Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser Asn Leu Arg
             420                 425                 430        
 Lys Ala Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His Asp Lys Ala
         435                 440                 445            
 Arg Phe Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly Ser Ala Pro
     450                 455                 460                
 Gly Ala Gly Ser Thr Ala Thr Lys Thr Leu Asp Lys Arg Arg Arg Leu
 465                 470                 475                 480
 Glu Glu Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala Thr Tyr Arg
                 485                 490                 495    
 Thr Cys Val Ala Asp Ala Lys Thr Gln Lys Gln Glu Leu Glu Asp Thr
             500                 505                 510        
 Lys Val Thr Ala Leu Arg Gln Ile Gln Glu Val Ile Arg Gln Ser Asp
         515                 520                 525            
 Gln Thr Ile Lys Ser Ala Thr Ile Ser Tyr Tyr Gln Met Met His Met
     530                 535                 540                
 Gln Thr Ala Pro Leu Pro Val His Phe Gln Met Leu Cys Glu Ser Ser
 545                 550                 555                 560
 Lys Leu Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val Arg Gln Leu
                 565                 570                 575    
 Gln Arg Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu Pro His Val
             580                 585                 590        
 Ser Ala Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys Ser Ser Phe
         595                 600                 605            
 Asn Val Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser Pro Pro Glu
     610                 615                 620                
 Glu Gly Gly Cys Thr Glu Gly Thr Pro Ala Lys Asp His Arg Ala Gly
 625                 630                 635                 640
 Arg Gly His Gln Val His Lys Ser Trp Pro Leu Ser Ile Ser Asp Ser
                 645                 650                 655    
 Asp Ser Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe Lys Lys Phe
             660                 665                 670        
 Glu Arg Thr Ser Ser Ser Gly Thr Met Ser Ser Thr Glu Glu Leu Val
         675                 680                 685            
 Asp Pro Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln Ala Asp Leu
     690                 695                 700                
 Asn Gly Met Thr Pro Glu Leu Pro Val Ala Val Pro Ser Gly Pro Phe
 705                 710                 715                 720
 Arg His Glu Gly Leu Ser Lys Ala Ala Arg Thr His Arg Leu Arg Lys
                 725                 730                 735    
 Leu Arg Thr Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr Val Tyr Phe
             740                 745                 750        
 Gln Gly Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His Lys Lys Cys
         755                 760                 765            
 Leu Glu Thr Leu Ala Ile Gln Cys Gly His Lys Lys Leu Gln Gly Arg
     770                 775                 780                
 Leu Gln Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg Ser Ala Pro
 785                 790                 795                 800
 Asp Gly Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu Ile Glu Arg
                 805                 810                 815    
 Arg Ala Leu Arg Thr Lys Gly Ile Tyr Arg Val Asn Gly Val Lys Thr
             820                 825                 830        
 Arg Val Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys Glu Leu Val
         835                 840                 845            
 Glu Leu Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val Leu Lys Leu
     850                 855                 860                
 Tyr Leu Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg Leu Tyr His
 865                 870                 875                 880
 Glu Leu Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu Ala Glu Ala
                 885                 890                 895    
 Lys Ala Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser Glu Ala Val
             900                 905                 910        
 Ala Val Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg Asp Leu Pro
         915                 920                 925            
 Pro Glu Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His Leu Arg Arg
     930                 935                 940                
 Ile Val Glu Val Glu Gln Asp Asn Lys Met Thr Pro Gly Asn Leu Gly
 945                 950                 955                 960
 Ile Val Phe Gly Pro Thr Leu Leu Arg Pro Arg Pro Thr Glu Ala Thr
                 965                 970                 975    
 Val Ser Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala Arg Val Ile
             980                 985                 990        
 Glu Thr Leu Ile Val His Tyr Gly Leu Val Phe Glu Glu Glu Pro Glu
         995                1000                1005            
 Glu Thr Pro Gly Gly Gln Asp Glu Ser Ser Asn Gln Arg Ala Glu Val
    1010                1015                1020                
 Val Val Gln Val Pro Tyr Leu Glu Ala Gly Glu Ala Val Val Tyr Pro
1025                1030                1035                1040
 Leu Gln Glu Ala Ala Ala Asp Gly Cys Arg Glu Ser Arg Val Val Ser
                1045                1050                1055    
 Asn Asp Ser Asp Ser Asp Leu Glu Glu Ala Ser Glu Leu Leu Ser Ser
            1060                1065                1070        
 Ser Glu Ala Ser Ala Leu Gly His Leu Ser Phe Leu Glu Gln Gln Gln
        1075                1080                1085            
 Ser Glu Ala Ser Leu Glu Val Ala Ser Gly Ser His Ser Gly Ser Glu
    1090                1095                1100                
 Glu Gln Leu Glu Ala Thr Ala Arg Glu Asp Gly Asp Gly Asp Glu Asp
1105                1110                1115                1120
 Gly Pro Ala Gln Gln Leu Ser Gly Phe Asn Thr Asn Gln Ser Asn Asn
                1125                1130                1135    
 Val Leu Gln Ala Pro Leu Pro Pro Met Arg Leu Arg Gly Gly Arg Met
            1140                1145                1150        
 Thr Leu Gly Ser Cys Arg Glu Arg Gln Pro Glu Phe Val
        1155                1160                1165



      <210> 2006
      <211> 208
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(208)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2006
 Ser Val Gly Ala Leu Asp Thr Phe Ile Ala Ala Val Tyr Glu His Ala
   1               5                  10                  15    
 Val Ile Leu Pro Asn Arg Ala Glu Thr Pro Val Ser Lys Glu Glu Ala
              20                  25                  30        
 Leu Leu Leu Met Asn Lys Asn Ile Asp Val Leu Glu Lys Ala Val Lys
          35                  40                  45            
 Leu Ala Ala Lys Gln Gly Ala His Ile Ile Val Thr Pro Glu Asp Gly
      50                  55                  60                
 Ile Tyr Gly Trp Ile Phe Thr Arg Glu Ser Ile Tyr Pro Tyr Leu Glu
  65                  70                  75                  80
 Asp Ile Pro Asp Pro Gly Val Asn Trp Ile Pro Cys Arg Asp Pro Trp
                  85                  90                  95    
 Arg Asn His Xaa Asn Ile Val Ser Leu Arg Lys Cys Leu Leu Asn Arg
             100                 105                 110        
 Phe Gly Asn Thr Pro Val Gln Gln Arg Leu Ser Cys Leu Ala Lys Asp
         115                 120                 125            
 Asn Ser Ile Tyr Val Val Ala Asn Ile Gly Asp Lys Lys Pro Cys Asn
     130                 135                 140                
 Ala Ser Asp Ser Gln Cys Pro Pro Asp Gly Arg Tyr Gln Tyr Asn Thr
 145                 150                 155                 160
 Asp Val Val Phe Asp Ser Gln Gly Lys Leu Leu Ala Arg Tyr His Lys
                 165                 170                 175    
 Tyr Asn Leu Phe Ala Pro Glu Ile Gln Phe Asp Phe Pro Lys Asp Ser
             180                 185                 190        
 Glu Leu Val Thr Phe Asp Thr Pro Phe Gly Lys Ile Gly Ile Ile Thr
         195                 200                 205            





      <210> 2007
      <211> 130
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(130)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2007
 Arg Thr Phe Thr Ser Xaa Cys Ser Val Ser Cys Gly Arg Gly Val Gln
   1               5                  10                  15    
 Gln Arg His Val Gly Cys Gln Ile Gly Thr His Lys Ile Ala Arg Glu
              20                  25                  30        
 Thr Glu Cys Asn Pro Tyr Thr Arg Pro Glu Ser Glu Arg Asp Cys Gln
          35                  40                  45            
 Gly Pro Arg Cys Pro Leu Tyr Thr Trp Arg Ala Glu Glu Trp Gln Glu
      50                  55                  60                
 Val Ser Arg Ala Thr Lys Gly Tyr Leu Pro Gly Ile Ser Arg Val Arg
  65                  70                  75                  80
 Pro Leu Leu Ser Ser His Leu Phe Pro Ile Lys Pro Glu Lys Ser Pro
                  85                  90                  95    
 Ser Thr Val Thr Met Leu Ala Leu Ser Gln Lys Val His Cys Gln Thr
             100                 105                 110        
 Arg Ala Phe Ala Pro Thr Arg Val Gly Glu Leu Leu Val Phe Lys Gln
         115                 120                 125            
 Phe Leu
     130



      <210> 2008
      <211> 415
      <212> PRT
      <213> Homo sapiens


      <400> 2008
 Leu Leu Ser Thr Tyr Ile Lys Phe Ile Asn Leu Phe Pro Glu Thr Lys
   1               5                  10                  15    
 Ala Thr Ile Gln Gly Val Leu Arg Ala Gly Ser Gln Leu Arg Asn Ala
              20                  25                  30        
 Asp Val Glu Leu Gln Gln Arg Ala Val Glu Tyr Leu Thr Leu Ser Ser
          35                  40                  45            
 Val Ala Ser Thr Asp Val Leu Ala Thr Val Leu Glu Glu Met Pro Pro
      50                  55                  60                
 Phe Pro Glu Arg Glu Ser Ser Ile Leu Ala Lys Leu Lys Arg Lys Lys
  65                  70                  75                  80
 Gly Pro Gly Ala Gly Ser Ala Leu Asp Asp Gly Arg Arg Asp Pro Ser
                  85                  90                  95    
 Ser Asn Asp Ile Asn Gly Gly Met Glu Pro Thr Pro Ser Thr Val Ser
             100                 105                 110        
 Thr Pro Ser Pro Ser Ala Asp Leu Leu Gly Leu Arg Ala Ala Pro Pro
         115                 120                 125            
 Pro Ala Ala Pro Pro Ala Ser Ala Gly Ala Gly Asn Leu Leu Val Asp
     130                 135                 140                
 Val Phe Asp Gly Pro Ala Ala Gln Pro Ser Leu Gly Pro Thr Pro Glu
 145                 150                 155                 160
 Glu Ala Phe Leu Ser Pro Gly Pro Glu Asp Ile Gly Pro Pro Ile Pro
                 165                 170                 175    
 Glu Ala Asp Glu Leu Leu Asn Lys Phe Val Cys Lys Asn Asn Gly Val
             180                 185                 190        
 Leu Phe Glu Asn Gln Leu Leu Gln Ile Gly Val Lys Ser Glu Phe Arg
         195                 200                 205            
 Gln Asn Leu Gly Arg Met Tyr Leu Phe Tyr Gly Asn Lys Thr Ser Val
     210                 215                 220                
 Gln Phe Gln Asn Phe Ser Pro Thr Val Val His Pro Gly Asp Leu Gln
 225                 230                 235                 240
 Thr Gln Leu Ala Val Gln Thr Lys Arg Val Ala Ala Gln Val Asp Gly
                 245                 250                 255    
 Gly Ala Gln Val Gln Gln Val Leu Asn Ile Glu Cys Leu Arg Asp Phe
             260                 265                 270        
 Leu Thr Pro Pro Leu Leu Ser Val Arg Phe Arg Tyr Gly Gly Ala Pro
         275                 280                 285            
 Gln Ala Leu Thr Leu Lys Leu Pro Val Thr Ile Asn Lys Phe Phe Gln
     290                 295                 300                
 Pro Thr Glu Met Ala Ala Gln Asp Phe Phe Gln Arg Trp Lys Gln Leu
 305                 310                 315                 320
 Ser Leu Pro Gln Gln Glu Ala Gln Lys Ile Phe Lys Ala Asn His Pro
                 325                 330                 335    
 Met Asp Ala Glu Val Thr Lys Ala Lys Leu Leu Gly Phe Gly Ser Ala
             340                 345                 350        
 Leu Leu Asp Asn Val Asp Pro Asn Pro Glu Asn Phe Val Gly Ala Gly
         355                 360                 365            
 Ile Ile Gln Thr Lys Ala Leu Gln Val Gly Cys Leu Leu Arg Leu Glu
     370                 375                 380                
 Pro Asn Ala Gln Ala Gln Met Tyr Arg Leu Thr Leu Arg Thr Ser Lys
 385                 390                 395                 400
 Glu Pro Val Ser Arg His Leu Cys Glu Leu Leu Ala Gln Gln Phe
                 405                 410                 415



      <210> 2009
      <211> 613
      <212> PRT
      <213> Homo sapiens


      <400> 2009
 Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu
   1               5                  10                  15    
 Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val
              20                  25                  30        
 Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser
          35                  40                  45            
 Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp
      50                  55                  60                
 Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser
  65                  70                  75                  80
 Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val
                  85                  90                  95    
 Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu
             100                 105                 110        
 Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His
         115                 120                 125            
 Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val
     130                 135                 140                
 Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro
 145                 150                 155                 160
 Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val
                 165                 170                 175    
 His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr
             180                 185                 190        
 Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu
         195                 200                 205            
 Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser
     210                 215                 220                
 Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala
 225                 230                 235                 240
 Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val
                 245                 250                 255    
 Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala
             260                 265                 270        
 Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu
         275                 280                 285            
 Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln
     290                 295                 300                
 Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu
 305                 310                 315                 320
 Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly
                 325                 330                 335    
 Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala
             340                 345                 350        
 Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly
         355                 360                 365            
 Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val
     370                 375                 380                
 Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp
 385                 390                 395                 400
 Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly
                 405                 410                 415    
 Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val
             420                 425                 430        
 His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala
         435                 440                 445            
 Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile
     450                 455                 460                
 Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp
 465                 470                 475                 480
 Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu
                 485                 490                 495    
 Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro
             500                 505                 510        
 Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg
         515                 520                 525            
 Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys
     530                 535                 540                
 Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala
 545                 550                 555                 560
 Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala
                 565                 570                 575    
 Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu
             580                 585                 590        
 Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys
         595                 600                 605            
 Arg Leu Arg Lys Arg
     610            



      <210> 2010
      <211> 613
      <212> PRT
      <213> Homo sapiens


      <400> 2010
 Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu
   1               5                  10                  15    
 Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val
              20                  25                  30        
 Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser
          35                  40                  45            
 Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp
      50                  55                  60                
 Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser
  65                  70                  75                  80
 Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val
                  85                  90                  95    
 Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu
             100                 105                 110        
 Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His
         115                 120                 125            
 Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val
     130                 135                 140                
 Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro
 145                 150                 155                 160
 Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val
                 165                 170                 175    
 His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr
             180                 185                 190        
 Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu
         195                 200                 205            
 Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser
     210                 215                 220                
 Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala
 225                 230                 235                 240
 Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val
                 245                 250                 255    
 Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala
             260                 265                 270        
 Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu
         275                 280                 285            
 Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln
     290                 295                 300                
 Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu
 305                 310                 315                 320
 Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly
                 325                 330                 335    
 Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala
             340                 345                 350        
 Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly
         355                 360                 365            
 Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val
     370                 375                 380                
 Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp
 385                 390                 395                 400
 Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly
                 405                 410                 415    
 Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val
             420                 425                 430        
 His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala
         435                 440                 445            
 Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile
     450                 455                 460                
 Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp
 465                 470                 475                 480
 Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu
                 485                 490                 495    
 Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro
             500                 505                 510        
 Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg
         515                 520                 525            
 Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys
     530                 535                 540                
 Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala
 545                 550                 555                 560
 Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala
                 565                 570                 575    
 Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu
             580                 585                 590        
 Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys
         595                 600                 605            
 Arg Leu Arg Lys Arg
     610            



      <210> 2011
      <211> 613
      <212> PRT
      <213> Homo sapiens


      <400> 2011
 Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu
   1               5                  10                  15    
 Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val
              20                  25                  30        
 Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser
          35                  40                  45            
 Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp
      50                  55                  60                
 Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser
  65                  70                  75                  80
 Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val
                  85                  90                  95    
 Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu
             100                 105                 110        
 Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His
         115                 120                 125            
 Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val
     130                 135                 140                
 Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro
 145                 150                 155                 160
 Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val
                 165                 170                 175    
 His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr
             180                 185                 190        
 Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu
         195                 200                 205            
 Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser
     210                 215                 220                
 Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala
 225                 230                 235                 240
 Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val
                 245                 250                 255    
 Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala
             260                 265                 270        
 Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu
         275                 280                 285            
 Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln
     290                 295                 300                
 Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu
 305                 310                 315                 320
 Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly
                 325                 330                 335    
 Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala
             340                 345                 350        
 Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly
         355                 360                 365            
 Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val
     370                 375                 380                
 Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp
 385                 390                 395                 400
 Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly
                 405                 410                 415    
 Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val
             420                 425                 430        
 His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala
         435                 440                 445            
 Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile
     450                 455                 460                
 Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp
 465                 470                 475                 480
 Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu
                 485                 490                 495    
 Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro
             500                 505                 510        
 Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg
         515                 520                 525            
 Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys
     530                 535                 540                
 Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala
 545                 550                 555                 560
 Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala
                 565                 570                 575    
 Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu
             580                 585                 590        
 Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys
         595                 600                 605            
 Arg Leu Arg Lys Arg
     610            



      <210> 2012
      <211> 613
      <212> PRT
      <213> Homo sapiens


      <400> 2012
 Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu
   1               5                  10                  15    
 Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val
              20                  25                  30        
 Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser
          35                  40                  45            
 Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp
      50                  55                  60                
 Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser
  65                  70                  75                  80
 Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val
                  85                  90                  95    
 Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu
             100                 105                 110        
 Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His
         115                 120                 125            
 Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val
     130                 135                 140                
 Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro
 145                 150                 155                 160
 Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val
                 165                 170                 175    
 His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr
             180                 185                 190        
 Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu
         195                 200                 205            
 Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser
     210                 215                 220                
 Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala
 225                 230                 235                 240
 Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val
                 245                 250                 255    
 Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala
             260                 265                 270        
 Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu
         275                 280                 285            
 Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln
     290                 295                 300                
 Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu
 305                 310                 315                 320
 Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly
                 325                 330                 335    
 Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala
             340                 345                 350        
 Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly
         355                 360                 365            
 Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val
     370                 375                 380                
 Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp
 385                 390                 395                 400
 Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly
                 405                 410                 415    
 Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val
             420                 425                 430        
 His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala
         435                 440                 445            
 Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile
     450                 455                 460                
 Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp
 465                 470                 475                 480
 Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu
                 485                 490                 495    
 Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro
             500                 505                 510        
 Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg
         515                 520                 525            
 Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys
     530                 535                 540                
 Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala
 545                 550                 555                 560
 Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala
                 565                 570                 575    
 Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu
             580                 585                 590        
 Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys
         595                 600                 605            
 Arg Leu Arg Lys Arg
     610            



      <210> 2013
      <211> 264
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(264)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2013
 Tyr Leu Arg Leu Trp Leu Arg His Phe Asp Pro Arg His Pro His Gly
   1               5                  10                  15    
 Val Pro Leu Pro Thr Glu Pro Ser Thr Pro Lys Ser Pro Ser Ala Gly
              20                  25                  30        
 Pro Ser Pro His Leu Leu His Pro Gly Thr Pro Gly His Pro Ser Ala
          35                  40                  45            
 Ser Pro Pro Ser Arg Pro Pro Ser Ser Ser Thr Pro Lys Arg Pro Arg
      50                  55                  60                
 Thr Ala Gly Arg Asn Pro Lys Arg Arg Gln Ser Ser Pro Gly Arg Pro
  65                  70                  75                  80
 Thr Asn Pro Gly Leu Arg Lys Lys Met Gly Pro Pro Ser Glu Gly Ser
                  85                  90                  95    
 Gly Gly Gly Asn Thr Pro Gln Gly Pro Ala Ser Gly Pro Ala Ser Leu
             100                 105                 110        
 Leu Pro Asn Pro Cys Xaa Leu Cys Arg Gly Lys Pro Leu Gly Val Leu
         115                 120                 125            
 Arg Gly Gly Gly Arg Arg Gly Ala Ser Val Pro Glu Ser Trp Pro His
     130                 135                 140                
 Ile Pro Ala Pro Asn Ala Gly Xaa Gly His Ala Gln Arg Asp Pro Gly
 145                 150                 155                 160
 Gly Ala Gly Gln Pro Lys Asp Xaa Gly Gly Arg Gly Ala Pro Gly Gln
                 165                 170                 175    
 Gln Ala Thr Glu Ala Asp Ser Gly Pro Ala Ala Gly Met Arg Gly Pro
             180                 185                 190        
 His Ile Ile Gln Leu Asp Thr Pro Leu Ser Ala Ser Arg Gly Met Arg
         195                 200                 205            
 Asn Ala Arg Gly Thr Phe Gly Met Pro Ser Leu Pro Arg Gly Asp Leu
     210                 215                 220                
 Ser Pro Ser Ser Ala Gly His Pro Pro Ala Ser Val Thr Leu Pro Gln
 225                 230                 235                 240
 Gly Pro His Phe Pro Lys Gly Thr Leu Ala Pro Gly Thr Leu Pro Pro
                 245                 250                 255    
 Ala Leu Phe Gly Asp Gln Glu Leu
             260                



      <210> 2014
      <211> 542
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(542)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2014
 Lys Lys Lys Glu Thr Val Ser Val Ser Ser Arg Glu Val Arg Glu Thr
   1               5                  10                  15    
 Ser Lys Ala Leu Glu Arg Pro Lys Leu Gln Glu Xaa Pro Arg Gly Pro
              20                  25                  30        
 Ala Leu Gln Ser Arg Ala Thr Ser Pro Arg Asn Thr Tyr Gln Arg Pro
          35                  40                  45            
 Ala Gly Trp Pro Gln Ala Glu Pro Pro Gln Xaa Gly Asn Arg Leu Phe
      50                  55                  60                
 Pro Ala Gly Val Arg Gly Arg Ala Pro Gly Pro His Pro Arg Ala Xaa
  65                  70                  75                  80
 Trp Ser Gln Pro Pro Ala Glu Asp Pro Thr Gly Arg Ala Glu Thr Gln
                  85                  90                  95    
 Leu Cys Pro Pro Ala Ala Leu Ala Arg Ala Gln Pro Arg Arg Gln Leu
             100                 105                 110        
 Cys Gly Pro Ala Leu Pro Gly Pro Arg Arg Pro Pro Thr Arg Thr Pro
         115                 120                 125            
 Thr Xaa Ser Gly Arg Gly Phe Ser Lys Trp Leu Ala Pro Glu Ile Thr
     130                 135                 140                
 Gln Gly Pro Ala Pro Asn Pro Phe Gly Phe Ser Asp Val Leu Phe Cys
 145                 150                 155                 160
 Val Phe Phe Lys Pro Phe Ser Leu Phe Arg Xaa Xaa Lys Asn Leu Xaa
                 165                 170                 175    
 Lys Thr Leu Leu Thr Asn Gln Pro Glu Pro Gln Glu Pro Lys Gly Cys
             180                 185                 190        
 Gly Gly Val Trp Arg Pro His Tyr Val Ser Gly Leu Leu Pro Thr Leu
         195                 200                 205            
 Lys Pro Cys Ser Leu Lys Arg Glu Gly Pro Arg Pro Ala Leu Pro Pro
     210                 215                 220                
 Ser Ser Pro Ser Pro Pro Pro Leu Cys Pro Ser Leu Arg Ser Pro Pro
 225                 230                 235                 240
 Ala Ser Leu Pro Pro Val Ile Leu Ala Phe Arg Val Pro Trp Arg Phe
                 245                 250                 255    
 Pro Xaa Pro Pro Val Lys Ile Gln Arg Leu Ser Pro Phe Phe Phe Asn
             260                 265                 270        
 Phe Asp Asn Xaa Pro Ser Val Ser Phe Ser Lys Phe Tyr Phe Ser Asn
         275                 280                 285            
 His Pro Gly Gln Pro Pro Ala Leu Ile Pro Ser Arg Pro Gly Leu Ser
     290                 295                 300                
 Gly Pro Pro Phe His Thr Leu Arg Phe Glu Thr Ala Val Phe Pro Thr
 305                 310                 315                 320
 Phe Ala Ala Gly Met Ala Val Ser Cys Pro Cys Leu Pro Ile Trp Pro
                 325                 330                 335    
 Ile Pro Gln Pro Trp Gly Pro Gly Ser Leu Pro Gln Pro Pro Pro Leu
             340                 345                 350        
 Leu Met Pro Xaa Lys Leu Gly Pro Arg Pro Cys Trp Pro Glu Pro Gln
         355                 360                 365            
 Met Pro Ser Ser Gly Ser Leu Thr Ser Gly Pro Asn Ser Ser Gly Leu
     370                 375                 380                
 Gly Ile Gly Pro Pro Tyr Pro Gly Ser Pro Pro Trp Gly Gln Xaa Lys
 385                 390                 395                 400
 Gly Lys Ala Phe Ile Leu Ala Asn Arg Pro His His Pro Leu Leu Pro
                 405                 410                 415    
 Gly Pro Pro Cys Arg Asp Gly Leu Ser Leu Pro Arg Pro Leu Leu Ser
             420                 425                 430        
 Val Cys Gly Ser Arg Thr Leu Cys Pro Ser Pro Gly Ala Ser Ala Val
         435                 440                 445            
 Thr Arg Leu Leu Lys Met Asn Ser Xaa Ile Leu Pro Ala His Pro Arg
     450                 455                 460                
 Pro Asp Pro Trp Ser Trp Pro Pro Ser Ser Pro Val Pro Glu Thr Ser
 465                 470                 475                 480
 Thr Pro Xaa Arg Xaa Thr Leu Gly Pro Pro Thr Ser Arg Thr Cys Arg
                 485                 490                 495    
 Pro Glu Val Pro Trp Ala Leu Pro Pro Ala Asn Trp Ala Thr Ser Phe
             500                 505                 510        
 Pro Pro Leu Thr Leu Gly Val Pro His Pro Leu Gln Gly Asp Tyr Ser
         515                 520                 525            
 Pro Asp Pro Thr Pro Val Ser Pro His Gly Pro Leu Leu Asn
     530                 535                 540        



      <210> 2015
      <211> 115
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(115)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2015
 Val Trp Ser Pro Asp Arg Pro Ser Ser Ser Asp Pro Arg Gly Gln Arg
   1               5                  10                  15    
 Arg Arg Pro Thr Gly Arg Val Ala Ala Asp Pro Gly Ala Ala Pro Pro
              20                  25                  30        
 Ala Ala Ala Ala Ala Pro Pro Pro Ser Ser Ala Xaa Thr Ala Pro Gly
          35                  40                  45            
 Ser Cys Arg Arg Trp Arg Thr Ser Ser Arg Arg Pro Thr Pro Gly Ser
      50                  55                  60                
 Asn Pro Arg Pro Thr Pro Pro Arg Pro Arg Ser Arg Ala Thr Ser Pro
  65                  70                  75                  80
 Thr Pro Asp Ser Ala Gln Arg Leu Pro Pro Pro Pro Pro Pro Ala Gly
                  85                  90                  95    
 Pro Gly Pro Pro Gly Pro Glu Ala Pro Pro Val Ser Leu Gly Gln Pro
             100                 105                 110        
 Phe Cys Arg
         115



      <210> 2016
      <211> 308
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(308)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2016
 Pro Leu Asp Arg Ala Val Glu Phe Ala Val Gly Ser Gly Arg Pro Arg
   1               5                  10                  15    
 Arg Ile Ser Cys Leu Ser Cys Pro Gly Gly Gly Gly Ala Ala Ser Gly
              20                  25                  30        
 Leu Gln Arg Ala Ala Gly Gly Thr Gly Leu Ser Trp Val Pro Ala Gly
          35                  40                  45            
 Leu Arg Val Cys Cys Ser Gln Arg Ser Glu Arg Pro Glu Lys Glu Glu
      50                  55                  60                
 Gln Pro Val Gln Asn Pro Arg Arg Lys Gly Lys Gly Gly Glu Ile Ser
  65                  70                  75                  80
 Thr Trp Lys Asn Ser Ser Met Lys Met Lys Glu Cys Leu Arg Ile Lys
                  85                  90                  95    
 Glu Arg Xaa Thr Met Lys Asn Ser His Arg Thr Arg Glu Ser Gln Lys
             100                 105                 110        
 Xaa Leu Val Phe Trp Lys Thr Arg Ser Xaa Lys Thr Arg Glu Thr Gln
         115                 120                 125            
 Lys Thr Arg Ala Arg Glu Leu Arg Asn Arg Xaa Arg Ile Lys Lys Ser
     130                 135                 140                
 Gln Arg Val Arg Glu Arg Gln Lys Glu Lys Glu Ser Gln Arg Gly Arg
 145                 150                 155                 160
 Glu Ser Gln Arg Cys Arg Glu Asp Gln Arg Gln Arg Glu Ser Gln Arg
                 165                 170                 175    
 Glu Gly Glu Gly Gln Arg Val Lys Glu Ser Gln Thr Trp Val Arg Glu
             180                 185                 190        
 Pro Glu Ser Glu Gly Glu Pro Glu Ser Glu Thr Arg Ala Ala Gly Lys
         195                 200                 205            
 Arg Pro Ala Glu Asp Asp Ile Pro Arg Lys Ala Lys Arg Lys Thr Asn
     210                 215                 220                
 Lys Gly Leu Ala Gln Tyr Leu Lys Gln Tyr Lys Glu Ala Ile His Asp
 225                 230                 235                 240
 Met Asn Phe Ser Asn Glu Asp Met Ile Arg Glu Phe Asp Asn Met Ala
                 245                 250                 255    
 Arg Val Glu Asp Lys Arg Arg Lys Ser Lys Gln Lys Leu Gly Ala Phe
             260                 265                 270        
 Leu Trp Met Gln Arg Asn Leu Gln Asp Pro Phe Tyr Pro Arg Gly Pro
         275                 280                 285            
 Arg Glu Phe Arg Gly Gly Cys Arg Ala Pro Arg Arg Asp Thr Glu Asp
     290                 295                 300                
 Ile Pro Tyr Val
 305            



      <210> 2017
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 2017
 Met Phe Leu Leu Leu Phe Cys Leu Met Phe Asp Phe Thr Lys Val Phe
   1               5                  10                  15    
 Phe Ile Leu Leu Leu His Ile Phe Cys Leu Ser Thr Cys Leu Phe Leu
              20                  25                  30        
 Gly Leu His Ile Cys Ala Ser Phe His Ala Arg Ala Leu Leu Glu Thr
          35                  40                  45            
 Ala Leu Ile Leu Leu Arg Met Lys Ile Ala Gly Phe Gln Val Ile Leu
      50                  55                  60                
 Phe Pro Gln Asp Phe Val Leu
  65                  70    



      <210> 2018
      <211> 266
      <212> PRT
      <213> Homo sapiens


      <400> 2018
 Phe Val Leu Asp Pro Tyr Ser Gly Val Ile Lys Ser Asn Val Ser Phe
   1               5                  10                  15    
 Asp Arg Glu Gln Gln Ser Ser Tyr Thr Phe Asp Val Lys Ala Thr Asp
              20                  25                  30        
 Gly Gly Gln Pro Pro Arg Ser Ser Thr Ala Lys Val Thr Ile Asn Val
          35                  40                  45            
 Met Asp Val Asn Asp Asn Ser Pro Val Val Ile Ser Pro Pro Ser Asn
      50                  55                  60                
 Thr Ser Phe Lys Leu Val Pro Leu Ser Ala Ile Pro Gly Ser Val Val
  65                  70                  75                  80
 Ala Glu Val Phe Ala Val Asp Val Asp Thr Gly Met Asn Ala Glu Leu
                  85                  90                  95    
 Lys Tyr Thr Ile Val Ser Gly Asn Asn Lys Gly Leu Phe Arg Ile Asp
             100                 105                 110        
 Pro Val Thr Gly Asn Ile Thr Leu Glu Glu Lys Pro Ala Pro Thr Asp
         115                 120                 125            
 Val Gly Leu His Arg Leu Val Val Asn Ile Ser Asp Leu Gly Tyr Pro
     130                 135                 140                
 Lys Ser Leu His Thr Leu Val Leu Val Phe Leu Tyr Val Asn Asp Thr
 145                 150                 155                 160
 Ala Gly Asn Ala Ser Tyr Ile Tyr Asp Leu Ile Arg Arg Thr Met Glu
                 165                 170                 175    
 Thr Pro Leu Asp Arg Asn Ile Gly Asp Ser Ser Gln Pro Tyr Gln Asn
             180                 185                 190        
 Glu Asp Tyr Leu Thr Ile Met Ile Ala Ile Ile Ala Gly Ala Met Val
         195                 200                 205            
 Val Ile Val Val Ile Phe Val Thr Val Leu Val Arg Cys Arg His Ala
     210                 215                 220                
 Ser Arg Phe Lys Ala Ala Gln Arg Ser Lys Gln Gly Ala Glu Trp Met
 225                 230                 235                 240
 Ser Pro Asn Gln Glu Asn Lys Gln Asn Lys Lys Lys Lys Arg Lys Lys
                 245                 250                 255    
 Arg Lys Ser Pro Lys Ser Ser Leu Leu Asn
             260                 265    



      <210> 2019
      <211> 443
      <212> PRT
      <213> Homo sapiens


      <400> 2019
 Gly Trp Asn Gly Ser Trp Asn Asp Asn Leu Val Asp Thr Ser Pro Leu
   1               5                  10                  15    
 Lys Arg Asp Pro Leu Gln Asp Ile Cys Arg Arg Tyr Met Glu Asp Leu
              20                  25                  30        
 Lys Lys Ile Cys Phe Tyr Arg Glu Leu Asn Ser Lys Thr Thr Leu Lys
          35                  40                  45            
 Phe Val His Thr Ser Phe His Gly Val Gly His Asp Tyr Val Gln Leu
      50                  55                  60                
 Ala Phe Lys Val Phe Gly Phe Lys Pro Pro Ile Pro Val Pro Glu Gln
  65                  70                  75                  80
 Lys Asp Pro Asp Pro Asp Phe Ser Thr Val Lys Cys Pro Asn Pro Glu
                  85                  90                  95    
 Glu Gly Glu Ser Val Leu Glu Leu Ser Leu Arg Leu Ala Glu Lys Glu
             100                 105                 110        
 Asn Ala Arg Val Val Leu Ala Thr Asp Pro Asp Ala Asp Arg Leu Ala
         115                 120                 125            
 Ala Ala Glu Leu Gln Glu Asn Gly Cys Trp Lys Val Phe Thr Gly Asn
     130                 135                 140                
 Glu Leu Ala Ala Leu Phe Gly Trp Trp Met Phe Asp Cys Trp Lys Lys
 145                 150                 155                 160
 Asn Lys Ser Arg Asn Ala Asp Val Lys Asn Val Tyr Met Leu Ala Thr
                 165                 170                 175    
 Thr Val Ser Ser Lys Ile Leu Lys Ala Ile Ala Leu Lys Glu Gly Phe
             180                 185                 190        
 His Phe Glu Glu Thr Leu Pro Gly Phe Lys Trp Ile Gly Ser Arg Ile
         195                 200                 205            
 Ile Asp Leu Leu Glu Asn Gly Lys Glu Val Leu Phe Ala Phe Glu Glu
     210                 215                 220                
 Ser Ile Gly Phe Leu Cys Gly Thr Ser Val Leu Asp Lys Asp Gly Val
 225                 230                 235                 240
 Ser Ala Ala Val Val Val Ala Glu Met Ala Ser Tyr Leu Glu Thr Met
                 245                 250                 255    
 Asn Ile Thr Leu Lys Gln Gln Leu Val Lys Val Tyr Glu Lys Tyr Gly
             260                 265                 270        
 Tyr His Ile Ser Lys Thr Ser Tyr Phe Leu Cys Tyr Glu Pro Pro Thr
         275                 280                 285            
 Ile Lys Ser Ile Phe Glu Arg Leu Arg Asn Phe Asp Ser Pro Lys Glu
     290                 295                 300                
 Tyr Pro Lys Phe Cys Gly Thr Phe Ala Ile Leu His Val Arg Asp Val
 305                 310                 315                 320
 Thr Thr Gly Tyr Asp Ser Ser Gln Pro Asn Lys Lys Ser Val Leu Pro
                 325                 330                 335    
 Val Ser Lys Asn Ser Gln Met Ile Thr Phe Thr Phe Gln Asn Gly Cys
             340                 345                 350        
 Val Ala Thr Leu Arg Thr Ser Gly Thr Glu Pro Lys Ile Lys Tyr Tyr
         355                 360                 365            
 Ala Glu Met Cys Ala Ser Pro Asp Gln Ser Asp Thr Ala Leu Leu Glu
     370                 375                 380                
 Glu Glu Leu Lys Lys Leu Ile Asp Ala Leu Ile Glu Asn Phe Leu Gln
 385                 390                 395                 400
 Pro Ser Lys Asn Gly Thr Gly Ser Gly Arg Ser Cys Leu Gly Val Pro
                 405                 410                 415    
 Pro Asn Thr Val Met Thr Leu Cys Gly Ala Tyr Gly Asn Arg Ala Thr
             420                 425                 430        
 Arg Arg Asn Cys His Thr Leu Glu Pro Cys Gly
         435                 440            



      <210> 2020
      <211> 777
      <212> PRT
      <213> Homo sapiens


      <400> 2020
 Thr Arg Phe Arg Gly Leu Arg Pro Ala Val Ala Pro Trp Thr Ala Leu
   1               5                  10                  15    
 Leu Ala Leu Gly Leu Pro Gly Trp Val Leu Ala Val Ser Ala Thr Ala
              20                  25                  30        
 Ala Ala Val Val Pro Glu Gln His Ala Ser Val Ala Gly Gln His Pro
          35                  40                  45            
 Leu Asp Trp Leu Leu Thr Asp Arg Gly Pro Phe His Arg Ala Gln Glu
      50                  55                  60                
 Tyr Ala Asp Phe Met Glu Arg Tyr Arg Gln Gly Phe Thr Thr Arg Tyr
  65                  70                  75                  80
 Arg Ile Tyr Arg Glu Phe Ala Arg Trp Lys Val Asn Asn Leu Ala Leu
                  85                  90                  95    
 Glu Arg Lys Asp Phe Phe Ser Leu Pro Leu Pro Leu Ala Pro Glu Phe
             100                 105                 110        
 Ile Arg Asn Ile Arg Leu Leu Gly Arg Arg Pro Asn Leu Gln Gln Val
         115                 120                 125            
 Thr Glu Asn Leu Ile Lys Lys Tyr Gly Thr His Phe Leu Leu Ser Ala
     130                 135                 140                
 Thr Leu Gly Gly Glu Glu Ser Leu Thr Ile Phe Val Asp Lys Gln Lys
 145                 150                 155                 160
 Leu Gly Arg Lys Thr Glu Thr Thr Gly Gly Ala Ser Ile Ile Gly Gly
                 165                 170                 175    
 Ser Gly Asn Ser Thr Ala Val Ser Leu Glu Thr Leu His Gln Leu Ala
             180                 185                 190        
 Ala Ser Tyr Phe Ile Asp Arg Glu Ser Thr Leu Arg Arg Leu His His
         195                 200                 205            
 Ile Gln Ile Ala Thr Gly Ala Ile Lys Val Thr Glu Thr Arg Thr Gly
     210                 215                 220                
 Pro Leu Gly Cys Ser Asn Tyr Asp Asn Leu Asp Ser Val Ser Ser Val
 225                 230                 235                 240
 Leu Val Gln Ser Pro Glu Asn Lys Val Gln Leu Leu Gly Leu Gln Val
                 245                 250                 255    
 Leu Leu Pro Glu Tyr Leu Arg Glu Arg Phe Val Ala Ala Ala Leu Ser
             260                 265                 270        
 Tyr Ile Thr Cys Ser Ser Glu Gly Glu Leu Val Cys Lys Glu Asn Asp
         275                 280                 285            
 Cys Trp Cys Lys Cys Ser Pro Thr Phe Pro Glu Cys Asn Cys Pro Asp
     290                 295                 300                
 Ala Asp Ile Gln Ala Met Glu Asp Ser Leu Leu Gln Ile Gln Asp Ser
 305                 310                 315                 320
 Trp Ala Thr His Asn Arg Gln Phe Glu Glu Ser Glu Glu Phe Gln Ala
                 325                 330                 335    
 Leu Leu Lys Arg Leu Pro Asp Asp Arg Phe Leu Asn Ser Thr Ala Ile
             340                 345                 350        
 Ser Gln Phe Trp Ala Met Asp Thr Ser Leu Gln His Arg Tyr Gln Gln
         355                 360                 365            
 Leu Gly Ala Gly Leu Lys Val Leu Phe Lys Lys Thr His Arg Ile Leu
     370                 375                 380                
 Arg Arg Leu Phe Asn Leu Cys Lys Arg Cys His Arg Gln Pro Arg Phe
 385                 390                 395                 400
 Arg Leu Pro Lys Glu Arg Ser Leu Ser Tyr Trp Trp Asn Arg Ile Gln
                 405                 410                 415    
 Ser Leu Leu Tyr Cys Gly Glu Ser Thr Phe Pro Gly Thr Phe Leu Glu
             420                 425                 430        
 Gln Ser His Ser Cys Thr Cys Pro Tyr Asp Gln Ser Ser Cys Gln Gly
         435                 440                 445            
 Pro Ile Pro Cys Ala Leu Gly Glu Gly Pro Ala Cys Ala His Cys Ala
     450                 455                 460                
 Pro Asp Asn Ser Thr Arg Cys Gly Ser Cys Asn Pro Gly Tyr Val Leu
 465                 470                 475                 480
 Ala Gln Gly Leu Cys Arg Pro Glu Val Ala Glu Ser Leu Glu Asn Phe
                 485                 490                 495    
 Leu Gly Leu Glu Thr Asp Leu Gln Asp Leu Glu Leu Lys Tyr Leu Leu
             500                 505                 510        
 Gln Lys Gln Asp Ser Arg Ile Glu Val His Ser Ile Phe Ile Ser Asn
         515                 520                 525            
 Asp Met Arg Leu Gly Ser Trp Phe Asp Pro Ser Trp Arg Lys Arg Met
     530                 535                 540                
 Leu Leu Thr Leu Lys Ser Asn Lys Tyr Lys Pro Gly Leu Val His Val
 545                 550                 555                 560
 Met Leu Ala Leu Ser Leu Gln Ile Cys Leu Thr Lys Asn Ser Thr Leu
                 565                 570                 575    
 Glu Pro Val Met Ala Ile Tyr Val Asn Pro Phe Gly Gly Ser His Ser
             580                 585                 590        
 Glu Ser Trp Phe Met Pro Val Asn Glu Gly Ser Phe Pro Asp Trp Glu
         595                 600                 605            
 Arg Thr Asn Val Asp Ala Ala Ala Gln Cys Gln Asn Trp Thr Ile Thr
     610                 615                 620                
 Leu Gly Asn Arg Trp Lys Thr Phe Phe Glu Thr Val His Val Tyr Leu
 625                 630                 635                 640
 Arg Ser Arg Ile Lys Ser Leu Asp Asp Ser Ser Asn Glu Thr Ile Tyr
                 645                 650                 655    
 Tyr Glu Pro Leu Glu Met Thr Asp Pro Ser Lys Asn Leu Gly Tyr Met
             660                 665                 670        
 Lys Ile Asn Thr Leu Gln Val Phe Gly Tyr Ser Leu Pro Phe Asp Pro
         675                 680                 685            
 Asp Ala Ile Arg Asp Leu Ile Leu Gln Leu Asp Tyr Pro Tyr Thr Gln
     690                 695                 700                
 Gly Ser Gln Asp Ser Ala Leu Leu Gln Leu Ile Glu Leu Arg Asp Arg
 705                 710                 715                 720
 Val Asn Gln Leu Ser Pro Pro Gly Lys Val Arg Leu Asp Leu Phe Ser
                 725                 730                 735    
 Cys Leu Leu Arg His Arg Leu Lys Leu Ala Asn Asn Glu Val Gly Arg
             740                 745                 750        
 Ile Gln Ser Ser Leu Arg Ala Phe Asn Ser Lys Leu Pro Asn Pro Val
         755                 760                 765            
 Glu Tyr Glu Thr Gly Lys Leu Cys Ser
     770                 775        



      <210> 2021
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 2021
 Pro Ala Gly Ile Gly Arg Ser Thr Ala Lys Thr Pro Gly Thr Pro Gly
   1               5                  10                  15    
 Ser Leu Glu Met Glu Asn Leu Lys Ser Gly Val Tyr Pro Leu Lys Glu
              20                  25                  30        
 Ala Ser Gly Cys Pro Gly Ala Asp Arg Asn Leu Leu Val Tyr Ser Phe
          35                  40                  45            
 Tyr Glu Lys Gly Pro Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser
      50                  55                  60                
 Leu Glu Glu Trp Gln Cys Leu Asp Thr Ala Gln Gln Asp Leu Tyr Arg
  65                  70                  75                  80
 Lys Val Met Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Ala Gly Ile
                  85                  90                  95    
 Ala Val Ser Lys Pro Asp Leu Ile Thr Cys Leu Glu Gln Gly Lys Glu
             100                 105                 110        
 Pro Trp Asn Met Lys Arg His Ala Met Val Asp Gln Pro Pro Gly Arg
         115                 120                 125            





      <210> 2022
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 2022
 Pro Ala Gly Ile Gly Arg Ser Thr Ala Lys Thr Pro Gly Thr Pro Gly
   1               5                  10                  15    
 Ser Leu Glu Met Glu Asn Leu Lys Ser Gly Val Tyr Pro Leu Lys Glu
              20                  25                  30        
 Ala Ser Gly Cys Pro Gly Ala Asp Arg Asn Leu Leu Val Tyr Ser Phe
          35                  40                  45            
 Tyr Glu Lys Gly Pro Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser
      50                  55                  60                
 Leu Glu Glu Trp Gln Cys Leu Asp Thr Ala Gln Gln Asp Leu Tyr Arg
  65                  70                  75                  80
 Lys Val Met Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Ala Gly Ile
                  85                  90                  95    
 Ala Val Ser Lys Pro Asp Leu Ile Thr Cys Leu Glu Gln Gly Lys Glu
             100                 105                 110        
 Pro Trp Asn Met Lys Arg His Ala Met Val Asp Gln Pro Pro Gly Arg
         115                 120                 125            





      <210> 2023
      <211> 150
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(150)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2023
 Ala Val Pro Gly Pro Gly Phe Gly Leu Ser Pro Thr Met Val Thr Leu
   1               5                  10                  15    
 Ala Glu Leu Leu Val Leu Leu Ala Ala Leu Leu Ala Thr Val Ser Gly
              20                  25                  30        
 Tyr Phe Val Ser Ile Asp Ala His Ala Glu Glu Cys Phe Phe Glu Arg
          35                  40                  45            
 Val Thr Ser Gly Thr Lys Met Gly Leu Ile Phe Glu Ala Glu Asp Gly
      50                  55                  60                
 Gly Phe Leu Asp Ile Asp Val Val Ile Thr Leu Pro Asp Arg Arg Lys
  65                  70                  75                  80
 Ile Lys Pro Arg Leu Leu Lys Lys Lys Gly Gln Xaa Thr Tyr Arg Ser
                  85                  90                  95    
 Phe Met Asp Val Thr Phe Lys Leu Cys Tyr Asn Leu Arg Met Ser Trp
             100                 105                 110        
 Met Asn Pro Asn Ile Arg Asn His Asn His Trp Leu Leu Leu Thr Ser
         115                 120                 125            
 Ile Lys Phe Leu Ile Thr Gln Phe Arg Ser Ser Leu Ser Tyr Leu Ser
     130                 135                 140                
 Ser Cys Ile Gln Ser Glu
 145                 150



      <210> 2024
      <211> 427
      <212> PRT
      <213> Homo sapiens


      <400> 2024
 Ile Thr Thr Val Met Ala Gly Lys Arg Ser Gly Trp Ser Arg Ala Ala
   1               5                  10                  15    
 Leu Leu Gln Leu Leu Leu Gly Val Asn Leu Gly Val Met Pro Pro Thr
              20                  25                  30        
 Arg Ala Arg Ser Leu Arg Phe Val Thr Leu Leu Tyr Arg His Gly Asp
          35                  40                  45            
 Arg Ser Pro Val Lys Thr Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Glu
      50                  55                  60                
 Trp Pro Gln Gly Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His
  65                  70                  75                  80
 Trp Glu Leu Gly Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn
                  85                  90                  95    
 Thr Ser Tyr His Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp
             100                 105                 110        
 Arg Thr Leu Met Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro
         115                 120                 125            
 Asn Gly Met Gln Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro
     130                 135                 140                
 Val His Thr Val Pro Ile Thr Glu Asp Arg Leu Leu Lys Phe Pro Leu
 145                 150                 155                 160
 Gly Pro Cys Pro Arg Tyr Glu Gln Leu Gln Asn Glu Thr Arg Gln Thr
                 165                 170                 175    
 Pro Glu Tyr Gln Asn Glu Ser Ser Arg Asn Ala Gln Phe Leu Asp Met
             180                 185                 190        
 Val Ala Asn Glu Thr Gly Leu Thr Asp Leu Thr Leu Glu Thr Val Trp
         195                 200                 205            
 Asn Val Tyr Asp Thr Leu Phe Cys Glu Gln Thr His Gly Leu Arg Leu
     210                 215                 220                
 Pro Pro Trp Ala Ser Pro Gln Thr Met Gln Arg Leu Ser Arg Leu Lys
 225                 230                 235                 240
 Asp Phe Ser Phe Arg Phe Leu Phe Gly Ile Tyr Gln Gln Ala Glu Lys
                 245                 250                 255    
 Ala Arg Leu Gln Gly Gly Val Leu Leu Ala Gln Ile Arg Lys Asn Leu
             260                 265                 270        
 Thr Leu Met Ala Thr Thr Ser Gln Leu Pro Lys Leu Leu Val Tyr Ser
         275                 280                 285            
 Ala His Asp Thr Thr Leu Val Ala Leu Gln Met Ala Leu Asp Val Tyr
     290                 295                 300                
 Asn Gly Glu Gln Ala Pro Tyr Ala Ser Cys His Ile Phe Glu Leu Tyr
 305                 310                 315                 320
 Gln Glu Asp Ser Gly Asn Phe Ser Val Glu Met Tyr Phe Arg Asn Glu
                 325                 330                 335    
 Ser Asp Lys Ala Pro Trp Pro Leu Ser Leu Pro Gly Cys Pro His Arg
             340                 345                 350        
 Cys Pro Leu Gln Asp Phe Leu Arg Leu Thr Glu Pro Val Val Pro Lys
         355                 360                 365            
 Asp Trp Gln Gln Glu Cys Gln Leu Ala Ser Gly Pro Ala Asp Thr Glu
     370                 375                 380                
 Val Ile Val Ala Leu Ala Val Cys Gly Ser Ile Leu Phe Leu Leu Ile
 385                 390                 395                 400
 Val Leu Leu Leu Thr Val Leu Phe Arg Met Gln Ala Gln Pro Pro Gly
                 405                 410                 415    
 Tyr Arg His Val Ala Asp Gly Glu Asp His Ala
             420                 425        



      <210> 2025
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 2025
 Phe Val Asp Ser Pro Arg Phe Arg Ala Thr Ile Asp Glu Val Glu Thr
   1               5                  10                  15    
 Asp Val Val Glu Ile Glu Ala Lys Leu Asp Lys Leu Val Lys Leu Cys
              20                  25                  30        
 Ser Gly Met Val Glu Ala Gly Lys Ala Tyr Val Ser Thr Ser Arg Leu
          35                  40                  45            
 Phe Val Ser Gly Val Arg Asp Leu Ser Gln Gln Cys Gln Gly Asp Thr
      50                  55                  60                
 Val Ile Ser Glu Cys Leu Gln Arg Phe Ala Asp Ser Leu Gln Glu Val
  65                  70                  75                  80
 Val Asn Tyr His Met Ile Leu Phe Asp Gln Ala Gln Arg Ser Val Arg
                  85                  90                  95    
 Gln Gln Leu Gln Ser Phe Val Lys Glu
             100                 105



      <210> 2026
      <211> 598
      <212> PRT
      <213> Homo sapiens


      <400> 2026
 Arg Thr Arg Gly Arg Phe Pro Lys Arg Thr Pro Leu Phe Gln Ile Ser
   1               5                  10                  15    
 Ser Ala Val Gln Lys Glu Gln Pro Leu Pro Thr Ala Glu Ile Thr Arg
              20                  25                  30        
 Leu Ala Val Trp Ala Ala Val Gln Ala Val Glu Arg Lys Leu Glu Ala
          35                  40                  45            
 Gln Ala Met Arg Leu Leu Thr Leu Glu Gly Arg Thr Gly Thr Asn Glu
      50                  55                  60                
 Lys Lys Ile Ala Asp Cys Glu Lys Thr Ala Val Glu Phe Ala Asn His
  65                  70                  75                  80
 Leu Glu Ser Lys Trp Val Val Leu Gly Thr Leu Leu Gln Glu Tyr Gly
                  85                  90                  95    
 Leu Leu Gln Arg Arg Leu Glu Asn Met Glu Asn Leu Leu Lys Asn Arg
             100                 105                 110        
 Asn Phe Trp Ile Leu Arg Leu Pro Pro Gly Ser Asn Gly Glu Val Pro
         115                 120                 125            
 Lys Val Pro Val Thr Phe Asp Asp Val Ala Val His Phe Ser Glu Gln
     130                 135                 140                
 Glu Trp Gly Asn Leu Ser Glu Trp Gln Lys Glu Leu Tyr Lys Asn Val
 145                 150                 155                 160
 Met Arg Gly Asn Tyr Glu Ser Leu Val Ser Met Asp Tyr Ala Ile Ser
                 165                 170                 175    
 Lys Pro Asp Leu Met Ser Gln Met Glu Arg Gly Glu Arg Pro Thr Met
             180                 185                 190        
 Gln Glu Gln Glu Asp Ser Glu Glu Gly Glu Thr Pro Thr Asp Pro Ser
         195                 200                 205            
 Ala Ala His Asp Gly Ile Val Ile Lys Ile Glu Val Gln Thr Asn Asp
     210                 215                 220                
 Glu Gly Ser Glu Ser Leu Glu Thr Pro Glu Pro Leu Met Gly Gln Val
 225                 230                 235                 240
 Glu Glu His Gly Phe Gln Asp Ser Glu Leu Gly Asp Pro Cys Gly Glu
                 245                 250                 255    
 Gln Pro Asp Leu Asp Met Gln Glu Pro Glu Asn Thr Leu Glu Glu Ser
             260                 265                 270        
 Thr Asp Arg Leu Gln Arg Val Gln Arg Thr Glu Ala Asp Ala Gly Ala
         275                 280                 285            
 Ala Glu Glu Leu His Gly Val Gly Ser Trp Ile Lys Thr Glu Glu Gln
     290                 295                 300                
 Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Leu Pro Gln His Leu
 305                 310                 315                 320
 Gln Ser Leu Gly Gln Leu Ser Gly Arg Tyr Glu Ala Ser Met Tyr Gln
                 325                 330                 335    
 Thr Pro Leu Pro Gly Glu Met Ser Pro Glu Gly Glu Glu Ser Pro Pro
             340                 345                 350        
 Pro Leu Gln Leu Gly Asn Pro Ala Val Lys Arg Leu Ala Pro Ser Val
         355                 360                 365            
 His Gly Glu Arg Pro Pro Glu Arg Glu Pro Arg Gly Leu Glu Pro Ala
     370                 375                 380                
 Ala Ala Glu Pro Ala Arg Arg Ala Ala Leu His Met His Gly Val Arg
 385                 390                 395                 400
 Gln Glu Leu Pro Pro Gly Arg Ser Thr Ser Ser Ser Thr Ser Ala Thr
                 405                 410                 415    
 Thr Ser Arg Arg Gly Pro Thr Ser Ala Pro Asn Ala Arg Ser Ala Ser
             420                 425                 430        
 Gly Thr Ser Asn Ser Ser Arg Cys Thr Ser Ala Ser Thr Ala Cys Ala
         435                 440                 445            
 Glu Ala Ala Ser His Pro Asn Cys Gly Pro Thr Phe Asn Pro Lys His
     450                 455                 460                
 Ala Leu Lys Pro Arg Pro Lys Ser Pro Ser Ser Gly Ser Gly Gly Gly
 465                 470                 475                 480
 Gly Pro Lys Pro Tyr Lys Cys Pro Glu Cys Asp Ser Ser Phe Ser His
                 485                 490                 495    
 Lys Ser Ser Leu Thr Lys His Gln Ile Thr His Thr Gly Glu Arg Pro
             500                 505                 510        
 Tyr Thr Cys Pro Glu Cys Lys Lys Ser Phe Arg Leu His Ile Ser Leu
         515                 520                 525            
 Val Ile His Gln Arg Val His Ala Gly Lys His Glu Val Ser Phe Ile
     530                 535                 540                
 Cys Ser Leu Cys Gly Lys Ser Phe Ser Arg Pro Ser His Leu Leu Arg
 545                 550                 555                 560
 His Gln Arg Thr His Thr Gly Glu Arg Pro Phe Lys Cys Pro Glu Cys
                 565                 570                 575    
 Glu Lys Ser Phe Ser Glu Lys Ser Lys Leu Thr Asn His Cys Arg Val
             580                 585                 590        
 His Ser Arg Glu Arg Pro
         595            



      <210> 2027
      <211> 584
      <212> PRT
      <213> Homo sapiens


      <400> 2027
 Glu Leu Asn Cys Asn Ile Arg Ala Pro Pro Lys Gln Met Phe Trp Cys
   1               5                  10                  15    
 Phe Arg Pro Arg Ser Lys Glu Arg Ala Val Val Val Ala Trp Glu Arg
              20                  25                  30        
 Arg Leu Met Val Val Gly Asp Ala Pro Glu Ser Ile Gln Phe Val Leu
          35                  40                  45            
 Asp Glu Asp Ser Tyr Leu Val Pro Glu Leu Asp Gly Val Arg Ile Phe
      50                  55                  60                
 Ser Arg Ser Thr His Glu Phe Leu His Glu Val Pro Ala Ala Ser Glu
  65                  70                  75                  80
 Glu Ile Phe Lys Ile Ala Ser Met Ala Pro Gly Ala Leu Leu Leu Glu
                  85                  90                  95    
 Ala Gln Lys Glu Tyr Glu Lys Glu Ser Gln Lys Ala Asp Glu Tyr Leu
             100                 105                 110        
 Arg Glu Ile Gln Glu Leu Gly Gln Leu Thr Gln Ala Val Gln Gln Cys
         115                 120                 125            
 Ile Glu Ala Ala Gly His Glu His Gln Pro Asp Met Gln Lys Ser Leu
     130                 135                 140                
 Leu Arg Ala Ala Ser Phe Gly Lys Cys Phe Leu Asp Arg Phe Pro Pro
 145                 150                 155                 160
 Asp Ser Phe Val His Met Cys Gln Asp Leu Arg Val Leu Asn Ala Val
                 165                 170                 175    
 Arg Asp Tyr His Ile Gly Ile Pro Leu Thr Tyr Ser Gln Tyr Lys Gln
             180                 185                 190        
 Leu Thr Ile Gln Val Leu Leu Asp Arg Leu Val Leu Arg Arg Leu Tyr
         195                 200                 205            
 Pro Leu Ala Ile Gln Ile Cys Glu Tyr Leu Arg Leu Pro Glu Val Gln
     210                 215                 220                
 Gly Val Ser Arg Ile Leu Ala His Trp Ala Cys Tyr Lys Val Gln Gln
 225                 230                 235                 240
 Lys Asp Val Ser Asp Glu Asp Val Ala Arg Ala Ile Asn Gln Lys Leu
                 245                 250                 255    
 Gly Asp Thr Pro Gly Val Ser Tyr Ser Asp Ile Ala Ala Arg Ala Tyr
             260                 265                 270        
 Gly Cys Gly Arg Thr Glu Leu Ala Ile Lys Leu Leu Glu Tyr Glu Pro
         275                 280                 285            
 Arg Ser Gly Glu Gln Val Pro Leu Leu Leu Lys Met Lys Arg Ser Lys
     290                 295                 300                
 Leu Ala Leu Ser Lys Ala Ile Glu Ser Gly Asp Thr Asp Leu Val Phe
 305                 310                 315                 320
 Thr Val Leu Leu His Leu Lys Asn Glu Leu Asn Arg Gly Asp Phe Phe
                 325                 330                 335    
 Met Thr Leu Arg Asn Gln Pro Met Ala Leu Ser Leu Tyr Arg Gln Phe
             340                 345                 350        
 Cys Lys His Gln Glu Leu Glu Thr Leu Lys Asp Leu Tyr Asn Gln Asp
         355                 360                 365            
 Asp Asn His Gln Glu Leu Gly Ser Phe His Ile Arg Ala Ser Tyr Ala
     370                 375                 380                
 Ala Glu Glu Arg Ile Glu Gly Arg Val Ala Ala Leu Gln Thr Ala Ala
 385                 390                 395                 400
 Asp Ala Phe Tyr Lys Ala Lys Asn Glu Phe Ala Ala Lys Ala Thr Glu
                 405                 410                 415    
 Asp Gln Met Arg Leu Leu Arg Leu Gln Arg Arg Leu Glu Asp Glu Leu
             420                 425                 430        
 Gly Gly Gln Phe Leu Asp Leu Ser Leu His Asp Thr Val Thr Thr Leu
         435                 440                 445            
 Ile Leu Gly Gly His Asn Lys Arg Ala Glu Gln Leu Ala Arg Asp Phe
     450                 455                 460                
 Arg Ile Pro Asp Lys Arg Leu Trp Trp Leu Lys Leu Thr Ala Leu Ala
 465                 470                 475                 480
 Asp Leu Glu Asp Trp Glu Glu Leu Glu Lys Phe Ser Lys Ser Lys Lys
                 485                 490                 495    
 Ser Pro Ile Gly Tyr Leu Pro Phe Val Glu Ile Cys Met Lys Gln His
             500                 505                 510        
 Asn Lys Tyr Glu Ala Lys Lys Tyr Ala Ser Arg Val Gly Pro Glu Gln
         515                 520                 525            
 Lys Val Lys Ala Leu Leu Leu Val Gly Asp Val Ala Gln Ala Ala Asp
     530                 535                 540                
 Val Ala Ile Glu His Arg Asn Glu Ala Glu Leu Ser Leu Val Leu Ser
 545                 550                 555                 560
 His Cys Thr Gly Ala Thr Asp Gly Ala Thr Ala Asp Lys Ile Gln Arg
                 565                 570                 575    
 Ala Arg Ala Gln Ala Gln Lys Lys
             580                



      <210> 2028
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 2028
 Met Leu Leu Ala Leu Pro Leu Ala Ala Pro Ser Cys Pro Met Leu Cys
   1               5                  10                  15    
 Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys Gln Ala Asn Asn Phe
              20                  25                  30        
 Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr Gln Arg Leu Phe Leu
          35                  40                  45            
 Gln Asn Asn Leu Ile Arg Thr Leu
      50                  55    



      <210> 2029
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 2029
 Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser Ser
   1               5                  10                  15    
 Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu Thr
              20                  25                  30        
 Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln Lys
          35                  40                  45            
 Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln Arg
      50                  55                  60                
 Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu
  65                  70                  75                  80
 Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Val Pro Ser Glu Glu
                  85                  90                  95    
 Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe Asn
             100                 105                 110        
 Ile Gln Ala Val Asn Arg Met
         115                



      <210> 2030
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 2030
 Ala Arg Pro Ser Cys Pro Cys Ser Trp Ser Phe Ser Cys Cys Gly Val
   1               5                  10                  15    
 Ser Pro Gly Ala Leu Val Thr Glu Ala Ala Ile Phe Tyr Glu Thr Gln
              20                  25                  30        
 Pro Ser Leu Trp Ala Glu Ser Glu Ser Leu Leu Lys Pro Leu Ala Lys
          35                  40                  45            
 Leu Met Thr Tyr Phe Lys Asn Ser Thr Tyr Leu Ile Arg Leu Phe Met
      50                  55                  60                
 Ile Tyr Arg Cys Lys Pro Val Lys Ser Lys Lys Lys Lys Arg Asn
  65                  70                  75                



      <210> 2031
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 2031
 Gly Lys Thr His Thr Ala Thr Val Val Glu Leu Asn Pro Trp Val Glu
   1               5                  10                  15    
 Tyr Glu Phe Arg Val Val Ala Ser Asn Lys Ile Gly Gly Gly Glu Pro
              20                  25                  30        
 Ser Leu Pro Ser Glu Lys Val Arg Thr Glu Glu Ala Val Pro Glu Val
          35                  40                  45            
 Pro Pro Ser Glu Val Asn Gly Gly Gly Gly Ser Arg Ser Glu Leu Val
      50                  55                  60                
 Ile Thr Trp Asp Pro Val Pro Glu Glu Leu Gln Asn Gly Glu Gly Phe
  65                  70                  75                  80
 Gly Tyr Val Val Ala Phe Arg Pro Leu Gly Val Thr Thr Trp Ile Gln
                  85                  90                  95    
 Thr Val Val Thr Ser Pro Asp Thr Pro Arg Tyr Val Phe Arg Asn Glu
             100                 105                 110        
 Ser Ile Val Pro Tyr Ser Pro Tyr Glu Val Lys Val Gly Val Tyr Asn
         115                 120                 125            
 Asn Lys Gly Glu Gly Pro Phe Ser Pro
     130                 135        



      <210> 2032
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 2032
 Ser Asn Leu His His Leu Ile Leu Asn Asn Asn Gln Leu Thr Leu Ile
   1               5                  10                  15    
 Ser Ser Thr Ala Phe Asp Asp Val Phe Ala Leu Glu Glu Leu Asp Leu
              20                  25                  30        
 Ser Tyr Asn Asn Leu Glu Thr Ile Pro Trp Asp Ala Val Glu Lys Met
          35                  40                  45            
 Val Ser Leu His Thr Leu Ser Leu Asp His Asn Met Ile Asp Asn Ile
      50                  55                  60                
 Pro Lys Gly Thr Phe Ser His Leu His Lys Met Thr Arg Leu Asp Val
  65                  70                  75                  80
 Thr Ser Asn Lys Leu Gln Lys Leu Pro Pro Asp Pro Leu Phe Gln Arg
                  85                  90                  95    
 Ala Gln Val Leu Ala Thr Ser Gly Ile Ile Ser Pro Ser Thr Phe Ala
             100                 105                 110        
 Leu Ser Phe Gly Gly Asn Pro Leu His Cys Asn Cys Glu Leu Leu Trp
         115                 120                 125            
 Leu Arg Arg Leu Ser Arg Glu Asp Asp Leu Glu Thr Cys Ala Ser Pro
     130                 135                 140                
 Pro
 145



      <210> 2033
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 2033
 Ser Asn Leu His His Leu Ile Leu Asn Asn Asn Gln Leu Thr Leu Ile
   1               5                  10                  15    
 Ser Ser Thr Ala Phe Asp Asp Val Phe Ala Leu Glu Glu Leu Asp Leu
              20                  25                  30        
 Ser Tyr Asn Asn Leu Glu Thr Ile Pro Trp Asp Ala Val Glu Lys Met
          35                  40                  45            
 Val Ser Leu His Thr Leu Ser Leu Asp His Asn Met Ile Asp Asn Ile
      50                  55                  60                
 Pro Lys Gly Thr Phe Ser His Leu His Lys Met Thr Arg Leu Asp Val
  65                  70                  75                  80
 Thr Ser Asn Lys Leu Gln Lys Leu Pro Pro Asp Pro Leu Phe Gln Arg
                  85                  90                  95    
 Ala Gln Val Leu Ala Thr Ser Gly Ile Ile Ser Pro Ser Thr Phe Ala
             100                 105                 110        
 Leu Ser Phe Gly Gly Asn Pro Leu His Cys Asn Cys Glu Leu Leu Trp
         115                 120                 125            
 Leu Arg Arg Leu Ser Arg Glu Asp Asp Leu Glu Thr Cys Ala Ser Pro
     130                 135                 140                
 Pro
 145



      <210> 2034
      <211> 1371
      <212> PRT
      <213> Homo sapiens


      <400> 2034
 Ala Ser Asp Gln Ser Gly Ser Gln Pro Gly Asp His Ser Ala Gly Gln
   1               5                  10                  15    
 Ala Asn Gln Leu Lys Leu Glu Asp Met Lys Ser Pro Arg Arg Thr Thr
              20                  25                  30        
 Leu Cys Leu Met Phe Ile Val Ile Tyr Ser Ser Lys Ala Ala Leu Asn
          35                  40                  45            
 Trp Asn Tyr Glu Ser Thr Ile His Pro Leu Ser Leu His Glu His Glu
      50                  55                  60                
 Pro Ala Gly Glu Glu Ala Leu Arg Gln Lys Arg Ala Val Ala Thr Lys
  65                  70                  75                  80
 Ser Pro Thr Ala Glu Glu Tyr Thr Val Asn Ile Glu Ile Ser Phe Glu
                  85                  90                  95    
 Asn Ala Ser Phe Leu Asp Pro Ile Lys Ala Tyr Leu Asn Ser Leu Ser
             100                 105                 110        
 Phe Pro Ile His Gly Asn Asn Thr Asp Gln Ile Thr Asp Ile Leu Ser
         115                 120                 125            
 Ile Asn Val Thr Thr Val Cys Arg Pro Ala Gly Asn Glu Ile Trp Cys
     130                 135                 140                
 Ser Cys Glu Thr Gly Tyr Gly Trp Pro Arg Glu Arg Cys Leu His Asn
 145                 150                 155                 160
 Leu Ile Cys Gln Glu Arg Asp Val Phe Leu Pro Gly His His Cys Ser
                 165                 170                 175    
 Cys Leu Lys Glu Leu Pro Pro Asn Gly Pro Phe Cys Leu Leu Gln Glu
             180                 185                 190        
 Asp Val Thr Leu Asn Met Arg Val Arg Leu Asn Val Gly Phe Gln Glu
         195                 200                 205            
 Asp Leu Met Asn Thr Ser Ser Ala Leu Tyr Arg Ser Tyr Lys Thr Asp
     210                 215                 220                
 Leu Glu Thr Ala Phe Arg Lys Gly Tyr Gly Ile Leu Pro Gly Phe Lys
 225                 230                 235                 240
 Gly Val Thr Val Thr Gly Phe Lys Ser Gly Ser Val Val Val Thr Tyr
                 245                 250                 255    
 Glu Val Lys Thr Thr Pro Pro Ser Leu Glu Leu Ile His Lys Ala Asn
             260                 265                 270        
 Glu Gln Val Val Gln Ser Leu Asn Gln Thr Tyr Lys Met Asp Tyr Asn
         275                 280                 285            
 Ser Phe Gln Ala Val Thr Ile Asn Glu Ser Asn Phe Phe Val Thr Pro
     290                 295                 300                
 Glu Ile Ile Phe Glu Gly Asp Thr Val Ser Leu Val Cys Glu Lys Glu
 305                 310                 315                 320
 Val Leu Ser Ser Asn Val Ser Trp Arg Tyr Glu Glu Gln Gln Leu Glu
                 325                 330                 335    
 Ile Gln Asn Ser Ser Arg Phe Ser Ile Tyr Thr Ala Leu Phe Asn Asn
             340                 345                 350        
 Met Thr Ser Val Ser Lys Leu Thr Ile His Asn Ile Thr Pro Gly Asp
         355                 360                 365            
 Ala Gly Glu Tyr Val Cys Lys Leu Ile Leu Asp Ile Phe Glu Tyr Glu
     370                 375                 380                
 Cys Lys Lys Lys Ile Asp Val Met Pro Ile Gln Ile Leu Ala Asn Glu
 385                 390                 395                 400
 Glu Met Lys Val Met Cys Asp Asn Asn Pro Val Ser Leu Asn Cys Cys
                 405                 410                 415    
 Ser Gln Gly Asn Val Asn Trp Ser Lys Val Glu Trp Lys Gln Glu Gly
             420                 425                 430        
 Lys Ile Asn Ile Pro Gly Thr Pro Glu Thr Asp Ile Asp Ser Ser Cys
         435                 440                 445            
 Ser Arg Tyr Thr Leu Lys Ala Asp Gly Thr Gln Cys Pro Ser Gly Ser
     450                 455                 460                
 Ser Gly Thr Thr Val Ile Tyr Thr Cys Glu Phe Ile Ser Ala Tyr Gly
 465                 470                 475                 480
 Ala Arg Gly Ser Ala Asn Ile Lys Val Thr Phe Ile Ser Val Ala Asn
                 485                 490                 495    
 Leu Thr Ile Thr Pro Asp Pro Ile Ser Val Ser Glu Gly Gln Asn Phe
             500                 505                 510        
 Ser Ile Lys Cys Ile Ser Asp Val Ser Asn Tyr Asp Glu Val Tyr Trp
         515                 520                 525            
 Asn Thr Ser Ala Gly Ile Lys Ile Tyr Gln Arg Phe Tyr Thr Thr Arg
     530                 535                 540                
 Arg Tyr Leu Asp Gly Ala Glu Ser Val Leu Thr Val Lys Thr Ser Thr
 545                 550                 555                 560
 Arg Glu Trp Asn Gly Thr Tyr His Cys Ile Phe Arg Tyr Lys Asn Ser
                 565                 570                 575    
 Tyr Ser Ile Ala Thr Lys Asp Val Ile Val His Pro Leu Pro Leu Lys
             580                 585                 590        
 Leu Asn Ile Met Val Asp Pro Leu Glu Ala Thr Val Ser Cys Ser Gly
         595                 600                 605            
 Ser His His Ile Lys Cys Cys Ile Glu Glu Asp Gly Asp Tyr Lys Val
     610                 615                 620                
 Thr Phe His Met Gly Ser Ser Ser Leu Pro Ala Ala Lys Glu Val Asn
 625                 630                 635                 640
 Lys Lys Gln Val Cys Tyr Lys His Asn Phe Asn Ala Ser Ser Val Ser
                 645                 650                 655    
 Trp Cys Ser Lys Thr Val Asp Val Cys Cys His Phe Thr Asn Ala Ala
             660                 665                 670        
 Asn Asn Ser Val Trp Ser Pro Ser Met Lys Leu Asn Leu Val Pro Gly
         675                 680                 685            
 Glu Asn Ile Thr Cys Gln Asp Pro Val Ile Gly Val Gly Glu Pro Gly
     690                 695                 700                
 Lys Val Ile Gln Lys Leu Cys Arg Phe Ser Asn Val Pro Ser Ser Pro
 705                 710                 715                 720
 Glu Glu Ser Pro Leu Gly Gly Thr Ile Thr Tyr Lys Cys Val Gly Ser
                 725                 730                 735    
 Gln Trp Gly Glu Lys Arg Asn Asp Cys Ile Ser Ala Pro Ile Asn Ser
             740                 745                 750        
 Leu Leu Gln Met Ala Lys Ala Leu Ile Lys Ser Pro Ser Gln Asp Glu
         755                 760                 765            
 Met Leu Pro Thr Tyr Leu Lys Asp Leu Ser Ile Ser Ile Asp Lys Ala
     770                 775                 780                
 Glu His Glu Ile Ser Ser Ser Pro Gly Ser Leu Gly Ala Ile Ile Asn
 785                 790                 795                 800
 Ile Leu Asp Leu Leu Ser Thr Val Pro Thr Gln Val Asn Ser Glu Met
                 805                 810                 815    
 Met Thr His Val Leu Ser Thr Val Asn Val Ile Leu Gly Lys Pro Val
             820                 825                 830        
 Leu Asn Thr Trp Lys Val Leu Gln Gln Gln Trp Thr Asn Gln Ser Ser
         835                 840                 845            
 Gln Leu Leu His Ser Val Glu Arg Phe Ser Gln Ala Leu Gln Ser Gly
     850                 855                 860                
 Asp Ser Pro Pro Leu Ser Phe Ser Gln Thr Asn Val Gln Met Ser Ser
 865                 870                 875                 880
 Thr Val Ile Lys Ser Ser His Pro Glu Thr Tyr Gln Gln Arg Phe Val
                 885                 890                 895    
 Phe Pro Tyr Phe Asp Leu Trp Gly Asn Val Val Ile Asp Lys Ser Tyr
             900                 905                 910        
 Leu Glu Asn Leu Gln Ser Asp Ser Ser Ile Val Thr Met Ala Phe Pro
         915                 920                 925            
 Thr Leu Gln Ala Ile Leu Ala Gln Asp Ile Gln Glu Asn Asn Phe Ala
     930                 935                 940                
 Glu Ser Leu Val Met Thr Thr Thr Val Ser His Asn Thr Thr Met Pro
 945                 950                 955                 960
 Phe Arg Ile Ser Met Thr Phe Lys Asn Asn Ser Pro Ser Gly Gly Glu
                 965                 970                 975    
 Thr Lys Cys Val Phe Trp Asn Phe Arg Leu Ala Asn Asn Thr Gly Gly
             980                 985                 990        
 Trp Asp Ser Ser Gly Cys Tyr Val Glu Glu Gly Asp Gly Asp Asn Val
         995                1000                1005            
 Thr Cys Ile Cys Asp His Leu Thr Ser Phe Ser Ile Leu Met Ser Pro
    1010                1015                1020                
 Asp Ser Pro Asp Pro Ser Ser Leu Leu Gly Ile Leu Leu Asp Ile Ile
1025                1030                1035                1040
 Ser Tyr Val Gly Val Gly Phe Ser Ile Leu Ser Leu Ala Ala Cys Leu
                1045                1050                1055    
 Val Val Glu Ala Val Val Trp Lys Ser Val Thr Lys Asn Arg Thr Ser
            1060                1065                1070        
 Tyr Met Arg His Thr Cys Ile Val Asn Ile Ala Ala Ser Leu Leu Val
        1075                1080                1085            
 Ala Asn Thr Trp Phe Ile Gly Val Ala Ala Ile Gln Asp Asn Arg Tyr
    1090                1095                1100                
 Ile Leu Cys Lys Thr Ala Cys Val Ala Ala Thr Phe Phe Ile His Phe
1105                1110                1115                1120
 Phe Tyr Leu Ser Val Phe Phe Trp Met Leu Thr Leu Gly Leu Met Leu
                1125                1130                1135    
 Phe Tyr Arg Leu Val Phe Ile Leu His Glu Thr Ser Arg Ser Thr Gln
            1140                1145                1150        
 Lys Ala Ile Ala Phe Cys Leu Gly Tyr Gly Cys Pro Leu Ala Ile Ser
        1155                1160                1165            
 Val Ile Thr Leu Gly Ala Thr Gln Pro Arg Glu Val Tyr Thr Arg Lys
    1170                1175                1180                
 Asn Val Cys Trp Leu Asn Trp Glu Asp Thr Lys Ala Leu Leu Ala Phe
1185                1190                1195                1200
 Ala Ile Pro Ala Leu Ile Ile Val Val Val Asn Ile Thr Ile Thr Ile
                1205                1210                1215    
 Val Val Ile Thr Lys Ile Leu Arg Pro Ser Ile Gly Asp Lys Pro Cys
            1220                1225                1230        
 Lys Gln Glu Lys Ser Ser Leu Phe Gln Ile Ser Lys Ser Ile Gly Val
        1235                1240                1245            
 Leu Thr Pro Leu Leu Gly Leu Thr Trp Gly Phe Gly Leu Thr Thr Val
    1250                1255                1260                
 Phe Pro Gly Thr Asn Leu Val Phe His Ile Ile Phe Ala Ile Leu Asn
1265                1270                1275                1280
 Val Phe Gln Gly Leu Phe Ile Leu Leu Phe Gly Cys Leu Trp Asp Leu
                1285                1290                1295    
 Lys Val Gln Glu Ala Leu Leu Asn Lys Phe Ser Leu Ser Arg Trp Ser
            1300                1305                1310        
 Ser Gln His Ser Lys Ser Thr Ser Leu Gly Ser Ser Thr Pro Val Phe
        1315                1320                1325            
 Ser Met Ser Ser Pro Ile Ser Arg Arg Phe Asn Asn Leu Phe Gly Lys
    1330                1335                1340                
 Thr Gly Thr Tyr Asn Val Ser Thr Pro Glu Ala Thr Ser Ser Ser Leu
1345                1350                1355                1360
 Glu Asn Ser Ser Ser Ala Ser Ser Leu Leu Asn
                1365                1370    



      <210> 2035
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 2035
 Ala Phe Arg Ser Asp Ser Arg Leu Ala Glu His Gln Arg Val His Thr
   1               5                  10                  15    
 Gly Glu Arg Pro Tyr Thr Cys Asn Glu Cys Gly Lys Val Phe Ser Thr
              20                  25                  30        
 Lys Ala Tyr Leu Ala Cys His Gln Lys Leu His Thr Gly Glu Lys Leu
          35                  40                  45            
 Tyr Glu Cys Glu Glu Cys Asp Lys Val Tyr Ile Arg Lys Ser His Leu
      50                  55                  60                
 Glu Arg His Arg Arg Ile His Thr Gly Glu Lys Pro His Lys Cys Gly
  65                  70                  75                  80
 Asp Cys Gly Lys Ala Phe Asn Ser Pro Ser His Leu Ile Arg His Gln
                  85                  90                  95    
 Arg Ile His Thr Gly Gln Lys Ser Tyr Lys Cys His Gln Cys Gly Lys
             100                 105                 110        
 Val Phe Ser Leu Arg Ser Leu Leu Ala Glu
         115                 120        



      <210> 2036
      <211> 78
      <212> PRT
      <213> Homo sapiens


      <400> 2036
 Ile Ser Gly Gln Glu Gly Leu Gln Ala Val Leu Ala Ser Asp Tyr Ser
   1               5                  10                  15    
 Phe Ala Gln Phe Arg Tyr Leu Gln Arg Leu Leu Leu Val His Gly Arg
              20                  25                  30        
 Trp Ser Tyr Phe Arg Met Cys Lys Phe Leu Cys Tyr Phe Phe Tyr Lys
          35                  40                  45            
 Asn Phe Ala Phe Thr Leu Val His Phe Trp Phe Gly Phe Phe Cys Gly
      50                  55                  60                
 Phe Ser Ala Gln Thr Val Tyr Asp Gln Trp Phe Ile Thr Leu
  65                  70                  75            



      <210> 2037
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 2037
 Met Arg Cys Gly Trp Gly Pro Leu Gly Cys Leu Gly Thr Gly Ala Pro
   1               5                  10                  15    
 Ala Gly Trp Met Val Leu Gly Ser Pro Arg Ser Gln Leu Gln Arg Ala
              20                  25                  30        
 Arg Trp Ser Arg Ala Ser Leu Ser Ala Phe Gly Trp Glu Ile Arg Leu
          35                  40                  45            
 Arg Pro Glu Gly Pro Lys Ala Pro Arg Gln Leu Leu Leu Val Ala Leu
      50                  55                  60                
 Glu Ser Glu Thr Leu Gly Val His Gly Gly Ala Thr Pro Leu His Cys
  65                  70                  75                  80
 Leu
    



      <210> 2038
      <211> 270
      <212> PRT
      <213> Homo sapiens


      <400> 2038
 Pro Gly Ser Pro Asp Val Asn Arg Ala Val Val Arg Pro Pro Pro Pro
   1               5                  10                  15    
 Pro Pro Pro Pro Pro Pro Ala Pro Gln Pro Thr Met Ser Arg Arg Lys
              20                  25                  30        
 Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu Phe Ser Pro Glu Pro
          35                  40                  45            
 Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp His Gly Pro Leu Gly
      50                  55                  60                
 Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys Gly Gln Cys Gln Met
  65                  70                  75                  80
 Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile Glu His Lys Arg Lys
                  85                  90                  95    
 Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala Val Asp Lys Pro Pro
             100                 105                 110        
 Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser Asn Pro Val Glu Val
         115                 120                 125            
 Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys Leu Ser Thr Ser Ser
     130                 135                 140                
 Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala Asp Lys Leu Leu His
 145                 150                 155                 160
 Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His Gly Ala Leu Ile Pro
                 165                 170                 175    
 Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln Gly Ile Cys Lys Asp
             180                 185                 190        
 Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys Gln Pro Phe Thr Ser
         195                 200                 205            
 Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr His Gly Leu Arg Ile
     210                 215                 220                
 Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr Pro Arg Val Leu His
 225                 230                 235                 240
 Thr Pro Pro Phe Gly Val Val Pro Arg Glu Leu Lys Met Cys Gly Ser
                 245                 250                 255    
 Phe Arg Met Glu Ala Arg Glu Pro Leu Ser Ser Glu Lys Ile
             260                 265                 270



      <210> 2039
      <211> 404
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(404)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2039
 Met His Ser Ala Met Leu Gly Thr Arg Val Asn Leu Ser Val Ser Asp
   1               5                  10                  15    
 Phe Trp Arg Val Met Met Arg Val Cys Trp Leu Val Arg Gln Asp Ser
              20                  25                  30        
 Arg His Gln Arg Ile Arg Leu Pro His Leu Glu Ala Val Val Ile Gly
          35                  40                  45            
 Arg Gly Pro Glu Thr Lys Ile Thr Asp Lys Lys Cys Ser Arg Gln Gln
      50                  55                  60                
 Val Gln Leu Lys Ala Glu Cys Asn Lys Gly Tyr Val Lys Val Lys Gln
  65                  70                  75                  80
 Val Gly Val Asn Pro Thr Ser Ile Asp Ser Val Val Ile Gly Lys Asp
                  85                  90                  95    
 Gln Glu Val Lys Leu Gln Pro Gly Gln Val Leu His Met Val Asn Glu
             100                 105                 110        
 Leu Tyr Pro Tyr Ile Val Glu Phe Glu Glu Glu Ala Lys Asn Pro Gly
         115                 120                 125            
 Leu Glu Thr His Arg Lys Arg Lys Arg Ser Gly Asn Ser Asp Ser Ile
     130                 135                 140                
 Glu Arg Asp Ala Ala Gln Glu Ala Glu Ala Gly Thr Gly Leu Glu Pro
 145                 150                 155                 160
 Gly Ser Asn Ser Gly Gln Cys Ser Val Pro Leu Lys Lys Gly Lys Asp
                 165                 170                 175    
 Ala Pro Ile Lys Lys Glu Ser Leu Gly His Trp Ser Gln Gly Leu Lys
             180                 185                 190        
 Ile Ser Met Gln Asp Pro Lys Met Gln Val Tyr Lys Asp Glu Gln Val
         195                 200                 205            
 Val Val Ile Lys Asp Lys Tyr Pro Lys Ala Arg Tyr His Trp Leu Val
     210                 215                 220                
 Leu Pro Trp Thr Ser Ile Ser Ser Leu Lys Ala Val Ala Arg Gly Thr
 225                 230                 235                 240
 Pro Xaa Thr Pro Xaa Ala Tyr Ala His Cys Gly Gly Lys Gly Asp Cys
                 245                 250                 255    
 Arg Phe Cys Trp Ser Ser Lys Leu Arg Phe Arg Leu Gly Tyr His Ala
             260                 265                 270        
 Ile Pro Ser Met Ser His Val His Leu His Val Ile Ser Gln Asp Phe
         275                 280                 285            
 Asp Ser Pro Cys Leu Lys Asn Lys Lys His Trp Asn Ser Phe Asn Thr
     290                 295                 300                
 Glu Tyr Phe Leu Glu Ser Gln Ala Val Ile Glu Met Val Gln Glu Ala
 305                 310                 315                 320
 Gly Arg Val Thr Val Arg Asp Gly Met Pro Glu Leu Leu Lys Leu Pro
                 325                 330                 335    
 Leu Arg Cys His Glu Cys Gln Gln Leu Leu Pro Ser Ile Pro Gln Leu
             340                 345                 350        
 Lys Glu His Leu Arg Lys His Trp Thr Gln Xaa Phe Phe Phe Phe Thr
         355                 360                 365            
 Val Leu Ser Lys Phe Ile Leu Arg Glu Lys Glu Ser Ser Gly Ser Thr
     370                 375                 380                
 Gln Leu Phe His Ser Pro Thr Thr Phe Pro Cys Ile Arg Thr Tyr Ala
 385                 390                 395                 400
 Val Ile Val Ser
                



      <210> 2040
      <211> 404
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(404)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2040
 Met His Ser Ala Met Leu Gly Thr Arg Val Asn Leu Ser Val Ser Asp
   1               5                  10                  15    
 Phe Trp Arg Val Met Met Arg Val Cys Trp Leu Val Arg Gln Asp Ser
              20                  25                  30        
 Arg His Gln Arg Ile Arg Leu Pro His Leu Glu Ala Val Val Ile Gly
          35                  40                  45            
 Arg Gly Pro Glu Thr Lys Ile Thr Asp Lys Lys Cys Ser Arg Gln Gln
      50                  55                  60                
 Val Gln Leu Lys Ala Glu Cys Asn Lys Gly Tyr Val Lys Val Lys Gln
  65                  70                  75                  80
 Val Gly Val Asn Pro Thr Ser Ile Asp Ser Val Val Ile Gly Lys Asp
                  85                  90                  95    
 Gln Glu Val Lys Leu Gln Pro Gly Gln Val Leu His Met Val Asn Glu
             100                 105                 110        
 Leu Tyr Pro Tyr Ile Val Glu Phe Glu Glu Glu Ala Lys Asn Pro Gly
         115                 120                 125            
 Leu Glu Thr His Arg Lys Arg Lys Arg Ser Gly Asn Ser Asp Ser Ile
     130                 135                 140                
 Glu Arg Asp Ala Ala Gln Glu Ala Glu Ala Gly Thr Gly Leu Glu Pro
 145                 150                 155                 160
 Gly Ser Asn Ser Gly Gln Cys Ser Val Pro Leu Lys Lys Gly Lys Asp
                 165                 170                 175    
 Ala Pro Ile Lys Lys Glu Ser Leu Gly His Trp Ser Gln Gly Leu Lys
             180                 185                 190        
 Ile Ser Met Gln Asp Pro Lys Met Gln Val Tyr Lys Asp Glu Gln Val
         195                 200                 205            
 Val Val Ile Lys Asp Lys Tyr Pro Lys Ala Arg Tyr His Trp Leu Val
     210                 215                 220                
 Leu Pro Trp Thr Ser Ile Ser Ser Leu Lys Ala Val Ala Arg Gly Thr
 225                 230                 235                 240
 Pro Xaa Thr Pro Xaa Ala Tyr Ala His Cys Gly Gly Lys Gly Asp Cys
                 245                 250                 255    
 Arg Phe Cys Trp Ser Ser Lys Leu Arg Phe Arg Leu Gly Tyr His Ala
             260                 265                 270        
 Ile Pro Ser Met Ser His Val His Leu His Val Ile Ser Gln Asp Phe
         275                 280                 285            
 Asp Ser Pro Cys Leu Lys Asn Lys Lys His Trp Asn Ser Phe Asn Thr
     290                 295                 300                
 Glu Tyr Phe Leu Glu Ser Gln Ala Val Ile Glu Met Val Gln Glu Ala
 305                 310                 315                 320
 Gly Arg Val Thr Val Arg Asp Gly Met Pro Glu Leu Leu Lys Leu Pro
                 325                 330                 335    
 Leu Arg Cys His Glu Cys Gln Gln Leu Leu Pro Ser Ile Pro Gln Leu
             340                 345                 350        
 Lys Glu His Leu Arg Lys His Trp Thr Gln Xaa Phe Phe Phe Phe Thr
         355                 360                 365            
 Val Leu Ser Lys Phe Ile Leu Arg Glu Lys Glu Ser Ser Gly Ser Thr
     370                 375                 380                
 Gln Leu Phe His Ser Pro Thr Thr Phe Pro Cys Ile Arg Thr Tyr Ala
 385                 390                 395                 400
 Val Ile Val Ser
                



      <210> 2041
      <211> 404
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(404)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2041
 Met His Ser Ala Met Leu Gly Thr Arg Val Asn Leu Ser Val Ser Asp
   1               5                  10                  15    
 Phe Trp Arg Val Met Met Arg Val Cys Trp Leu Val Arg Gln Asp Ser
              20                  25                  30        
 Arg His Gln Arg Ile Arg Leu Pro His Leu Glu Ala Val Val Ile Gly
          35                  40                  45            
 Arg Gly Pro Glu Thr Lys Ile Thr Asp Lys Lys Cys Ser Arg Gln Gln
      50                  55                  60                
 Val Gln Leu Lys Ala Glu Cys Asn Lys Gly Tyr Val Lys Val Lys Gln
  65                  70                  75                  80
 Val Gly Val Asn Pro Thr Ser Ile Asp Ser Val Val Ile Gly Lys Asp
                  85                  90                  95    
 Gln Glu Val Lys Leu Gln Pro Gly Gln Val Leu His Met Val Asn Glu
             100                 105                 110        
 Leu Tyr Pro Tyr Ile Val Glu Phe Glu Glu Glu Ala Lys Asn Pro Gly
         115                 120                 125            
 Leu Glu Thr His Arg Lys Arg Lys Arg Ser Gly Asn Ser Asp Ser Ile
     130                 135                 140                
 Glu Arg Asp Ala Ala Gln Glu Ala Glu Ala Gly Thr Gly Leu Glu Pro
 145                 150                 155                 160
 Gly Ser Asn Ser Gly Gln Cys Ser Val Pro Leu Lys Lys Gly Lys Asp
                 165                 170                 175    
 Ala Pro Ile Lys Lys Glu Ser Leu Gly His Trp Ser Gln Gly Leu Lys
             180                 185                 190        
 Ile Ser Met Gln Asp Pro Lys Met Gln Val Tyr Lys Asp Glu Gln Val
         195                 200                 205            
 Val Val Ile Lys Asp Lys Tyr Pro Lys Ala Arg Tyr His Trp Leu Val
     210                 215                 220                
 Leu Pro Trp Thr Ser Ile Ser Ser Leu Lys Ala Val Ala Arg Gly Thr
 225                 230                 235                 240
 Pro Xaa Thr Pro Xaa Ala Tyr Ala His Cys Gly Gly Lys Gly Asp Cys
                 245                 250                 255    
 Arg Phe Cys Trp Ser Ser Lys Leu Arg Phe Arg Leu Gly Tyr His Ala
             260                 265                 270        
 Ile Pro Ser Met Ser His Val His Leu His Val Ile Ser Gln Asp Phe
         275                 280                 285            
 Asp Ser Pro Cys Leu Lys Asn Lys Lys His Trp Asn Ser Phe Asn Thr
     290                 295                 300                
 Glu Tyr Phe Leu Glu Ser Gln Ala Val Ile Glu Met Val Gln Glu Ala
 305                 310                 315                 320
 Gly Arg Val Thr Val Arg Asp Gly Met Pro Glu Leu Leu Lys Leu Pro
                 325                 330                 335    
 Leu Arg Cys His Glu Cys Gln Gln Leu Leu Pro Ser Ile Pro Gln Leu
             340                 345                 350        
 Lys Glu His Leu Arg Lys His Trp Thr Gln Xaa Phe Phe Phe Phe Thr
         355                 360                 365            
 Val Leu Ser Lys Phe Ile Leu Arg Glu Lys Glu Ser Ser Gly Ser Thr
     370                 375                 380                
 Gln Leu Phe His Ser Pro Thr Thr Phe Pro Cys Ile Arg Thr Tyr Ala
 385                 390                 395                 400
 Val Ile Val Ser
                



      <210> 2042
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 2042
 Lys Met Thr Thr Ala Ala Arg Pro Thr Phe Glu Pro Ala Arg Gly Gly
   1               5                  10                  15    
 Arg Gly Lys Gly Glu Gly Asp Leu Ser Gln Leu Ser Lys Gln Tyr Ser
              20                  25                  30        
 Ser Arg Asp Leu Pro Ser His Thr Lys Ile Lys Tyr Arg Gln Thr Thr
          35                  40                  45            
 Gln Asp Ala Pro Glu Glu Val Arg Asn Arg Asp Phe Arg Arg Glu Leu
      50                  55                  60                
 Glu Glu Arg Glu Arg Ala Ala Ala Arg Glu Lys Asn Arg Asp Arg Pro
  65                  70                  75                  80
 Thr Arg Glu His Thr Thr Ser Ser Ser Val Ser Lys Lys Pro Arg Leu
                  85                  90                  95    
 Asp Gln Ile Pro Ala Ala Asn Leu Asp Ala Asp Asp Pro Leu Thr Asp
             100                 105                 110        
 Glu Glu Asp Glu Asp Phe Glu Glu Glu Ser Asp Asp Asp Asp Thr Ala
         115                 120                 125            
 Ala Leu Leu Ala Glu Leu Glu Lys Ile Lys Lys Glu Arg Ala Glu Glu
     130                 135                 140                
 Gln Ala Arg Lys Glu Gln Glu Gln Lys Ala Glu Glu Glu Arg Ile Arg
 145                 150                 155                 160
 Met Glu Asn Ile Leu Ser Gly Asn Pro Leu Leu Asn Leu Thr Gly Pro
                 165                 170                 175    
 Ser Gln Pro Gln Ala Asn Phe Lys Val Lys Arg Arg Trp Asp Asp Asp
             180                 185                 190        
 Val Val Phe Lys Asn Cys Ala Lys Gly Val Asp Asp Gln Lys Lys Asp
         195                 200                 205            
 Lys Arg Phe Val Asn Asp Thr Leu Arg Ser Glu Phe His Lys Lys Phe
     210                 215                 220                
 Met Glu Lys Tyr Ile Lys
 225                 230



      <210> 2043
      <211> 286
      <212> PRT
      <213> Homo sapiens


      <400> 2043
 Ala Thr Thr Arg Ile Arg Leu Ser Gly Gly Arg Ser Gln His Glu Gly
   1               5                  10                  15    
 Arg Val Glu Val Gln Ile Gly Gly Pro Gly Pro Leu Arg Trp Gly Leu
              20                  25                  30        
 Ile Cys Gly Asp Asp Trp Gly Thr Leu Glu Ala Met Val Ala Cys Arg
          35                  40                  45            
 Gln Leu Gly Leu Gly Tyr Ala Asn His Gly Leu Gln Glu Thr Trp Tyr
      50                  55                  60                
 Trp Asp Ser Gly Asn Ile Thr Glu Val Val Met Ser Gly Val Arg Cys
  65                  70                  75                  80
 Thr Gly Thr Glu Leu Ser Leu Asp Gln Cys Ala His His Gly Thr His
                  85                  90                  95    
 Ile Thr Cys Lys Arg Thr Gly Thr Arg Phe Thr Ala Gly Val Ile Cys
             100                 105                 110        
 Ser Glu Thr Ala Ser Asp Leu Leu Leu His Ser Ala Leu Val Gln Glu
         115                 120                 125            
 Thr Ala Tyr Ile Glu Asp Arg Pro Leu His Met Leu Tyr Cys Ala Ala
     130                 135                 140                
 Glu Glu Asn Cys Leu Ala Ser Ser Ala Arg Ser Ala Asn Trp Pro Tyr
 145                 150                 155                 160
 Gly His Arg Arg Leu Leu Arg Phe Ser Ser Gln Ile His Asn Leu Gly
                 165                 170                 175    
 Arg Ala Asp Phe Arg Pro Lys Ala Gly Arg His Ser Trp Val Trp His
             180                 185                 190        
 Glu Cys His Gly His Tyr His Ser Met Asp Phe Phe Thr His Tyr Asp
         195                 200                 205            
 Ile Leu Thr Pro Asn Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser
     210                 215                 220                
 Phe Cys Leu Glu Asp Thr Glu Cys Gln Glu Asp Val Ser Lys Arg Tyr
 225                 230                 235                 240
 Glu Cys Ala Asn Phe Gly Glu Gln Gly Ile Thr Val Gly Cys Trp Asp
                 245                 250                 255    
 Leu Tyr Arg His Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val
             260                 265                 270        
 Lys Pro Gly Asn Tyr Ile Leu His Gly Val Ile Asn Pro Thr
         275                 280                 285    



      <210> 2044
      <211> 235
      <212> PRT
      <213> Homo sapiens


      <400> 2044
 Ala Arg Gly Ser Leu Cys Ala Pro Ala Ser Pro Leu Tyr Pro Val Asn
   1               5                  10                  15    
 Gln Leu Arg Asn Val Ala Leu Ala Gln Ala Leu Thr Pro Tyr Val Phe
              20                  25                  30        
 Leu Ser Asp Ile Asp Phe Leu Pro Ala Tyr Ser Leu Tyr Asp Tyr Leu
          35                  40                  45            
 Arg Ala Ser Ile Glu Gln Leu Gly Leu Gly Ser Arg Arg Lys Ala Ala
      50                  55                  60                
 Leu Val Val Pro Ala Phe Glu Thr Leu Arg Tyr Arg Phe Ser Phe Pro
  65                  70                  75                  80
 His Ser Lys Val Glu Leu Leu Ala Leu Leu Asp Ala Gly Thr Leu Tyr
                  85                  90                  95    
 Thr Phe Arg Tyr His Glu Trp Pro Arg Gly His Ala Pro Thr Asp Tyr
             100                 105                 110        
 Ala Arg Trp Arg Glu Ala Gln Ala Pro Tyr Arg Val Gln Trp Ala Ala
         115                 120                 125            
 Asn Tyr Glu Pro Tyr Val Val Val Pro Arg Asp Cys Pro Arg Tyr Asp
     130                 135                 140                
 Pro Arg Phe Val Gly Phe Gly Trp Asn Lys Val Ala His Ile Val Glu
 145                 150                 155                 160
 Leu Asp Ala Gln Glu Tyr Glu Leu Leu Val Leu Pro Glu Ala Phe Thr
                 165                 170                 175    
 Ile His Leu Pro His Ala Pro Ser Leu Asp Ile Ser Arg Phe Arg Ser
             180                 185                 190        
 Ser Pro Thr Tyr Arg Asp Cys Leu Gln Ala Leu Lys Asp Glu Phe His
         195                 200                 205            
 Gln Asp Leu Ser Arg His His Gly Ala Ala Ala Leu Lys Tyr Leu Pro
     210                 215                 220                
 Ala Leu Gln Gln Pro Gln Ser Pro Ala Arg Gly
 225                 230                 235



      <210> 2045
      <211> 483
      <212> PRT
      <213> Homo sapiens


      <400> 2045
 Ala Val Val Arg Ala Gln Gly Ser Arg Gly Phe Ser Gly Ala Gly Trp
   1               5                  10                  15    
 Arg Pro Arg Gln Ala Ala Ala Met Asn Phe Ser Glu Val Phe Lys Leu
              20                  25                  30        
 Ser Ser Leu Leu Cys Lys Phe Ser Pro Asp Gly Lys Tyr Leu Ala Ser
          35                  40                  45            
 Cys Val Gln Tyr Arg Leu Val Val Arg Asp Val Asn Thr Leu Gln Ile
      50                  55                  60                
 Leu Gln Leu Tyr Thr Cys Leu Asp Gln Ile Gln His Ile Glu Trp Ser
  65                  70                  75                  80
 Ala Asp Ser Leu Phe Ile Leu Cys Ala Met Tyr Lys Arg Gly Leu Val
                  85                  90                  95    
 Gln Val Trp Ser Leu Glu Gln Pro Glu Trp His Cys Lys Ile Asp Glu
             100                 105                 110        
 Gly Ser Ala Gly Leu Val Ala Ser Cys Trp Ser Pro Asp Gly Arg His
         115                 120                 125            
 Ile Leu Asn Thr Thr Glu Phe His Leu Arg Ile Thr Val Trp Ser Leu
     130                 135                 140                
 Cys Thr Lys Ser Val Ser Tyr Ile Lys Tyr Pro Lys Ala Cys Leu Gln
 145                 150                 155                 160
 Gly Ile Thr Phe Thr Arg Asp Gly Arg Tyr Met Ala Leu Ala Glu Arg
                 165                 170                 175    
 Arg Asp Cys Lys Asp Tyr Val Ser Ile Phe Val Cys Ser Asp Trp Gln
             180                 185                 190        
 Leu Leu Arg His Phe Asp Thr Asp Thr Gln Asp Leu Thr Gly Ile Glu
         195                 200                 205            
 Trp Ala Pro Asn Gly Cys Val Leu Ala Val Trp Asp Thr Cys Leu Glu
     210                 215                 220                
 Tyr Lys Ile Leu Leu Tyr Ser Leu Asp Gly Arg Leu Leu Ser Thr Tyr
 225                 230                 235                 240
 Ser Ala Tyr Glu Trp Ser Leu Gly Ile Lys Ser Val Ala Trp Ser Pro
                 245                 250                 255    
 Ser Ser Gln Phe Leu Ala Val Gly Ser Tyr Asp Gly Lys Val Arg Ile
             260                 265                 270        
 Leu Asn His Val Thr Trp Lys Met Ile Thr Glu Phe Gly His Pro Ala
         275                 280                 285            
 Ala Ile Asn Asp Pro Lys Ile Val Val Tyr Lys Glu Ala Glu Lys Ser
     290                 295                 300                
 Pro Gln Leu Gly Leu Gly Cys Leu Ser Phe Pro Pro Pro Arg Ala Gly
 305                 310                 315                 320
 Ala Gly Pro Leu Pro Ser Ser Glu Ser Lys Tyr Glu Ile Ala Ser Val
                 325                 330                 335    
 Pro Val Ser Leu Gln Thr Leu Lys Pro Val Thr Asp Arg Ala Asn Pro
             340                 345                 350        
 Lys Ile Gly Ile Gly Met Leu Ala Phe Ser Pro Asp Ser Tyr Phe Leu
         355                 360                 365            
 Ala Thr Arg Asn Asp Asn Ile Pro Asn Ala Val Trp Val Trp Asp Ile
     370                 375                 380                
 Gln Lys Leu Arg Leu Phe Ala Val Leu Glu Gln Leu Ser Pro Val Arg
 385                 390                 395                 400
 Ala Phe Gln Trp Asp Pro Gln Gln Pro Arg Leu Ala Ile Cys Thr Gly
                 405                 410                 415    
 Gly Ser Arg Leu Tyr Leu Trp Ser Pro Ala Gly Cys Met Ser Val Gln
             420                 425                 430        
 Val Pro Gly Glu Gly Asp Phe Ala Val Leu Ser Leu Cys Trp His Leu
         435                 440                 445            
 Ser Gly Asp Ser Met Ala Leu Leu Ser Lys Asp His Phe Cys Leu Cys
     450                 455                 460                
 Phe Leu Glu Thr Glu Ala Val Val Gly Thr Ala Cys Arg Gln Leu Gly
 465                 470                 475                 480
 Gly His Thr
            



      <210> 2046
      <211> 352
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(352)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2046
 Ser Pro Thr Val Ser Phe Leu Phe Phe Asn Met Glu Thr Asn Pro Ser
   1               5                  10                  15    
 Val Gly Thr Thr Ser Ala Ile Ser Ile Leu Leu Ala Arg Ser Ser Arg
              20                  25                  30        
 Glu Arg Gln Leu Ser Ser Glu Gly Arg Phe Ser Trp Arg Leu Xaa Asp
          35                  40                  45            
 Ala Ser Ser Gly Glu Arg Ser Xaa Arg Arg Ser Glu Ser Ser Ser Trp
      50                  55                  60                
 Leu Ser Ser Xaa Glu Arg Glu Ser Ser Val Ser Phe Lys His Pro Phe
  65                  70                  75                  80
 Lys Arg Leu Phe Lys Xaa Ser Ser Val Ser Leu Leu Ser Trp Ser Ser
                  85                  90                  95    
 Leu Ser Pro Phe Ser Ser Gly Ala Ile His Thr Ser Gly Ser Ser Met
             100                 105                 110        
 Pro Lys Ser Asp Ile Xaa Leu Phe Pro Gln Ser Thr Phe Ser Glu Pro
         115                 120                 125            
 Ser Glu Ser Ala Cys Ala Cys Gly Asp Phe Pro Ser Leu Ser Val Arg
     130                 135                 140                
 Ser Gly Cys Cys Ser Ser Phe Asn Ser Leu Phe Ser Ser Trp Ser Val
 145                 150                 155                 160
 Gly Asn Ala Ser Glu Ala Ser Arg Ser Gly Lys Arg Ser Ser Phe Leu
                 165                 170                 175    
 Xaa Ala Cys Glu Tyr Leu Pro Ser Glu Ile Asn Ala Gly Gly Ile Arg
             180                 185                 190        
 Ser Gln Pro Gly Glu Ile Asn Gly Ser Val Phe Asp Leu Leu Glu Arg
         195                 200                 205            
 Asn Thr Leu Gly Ser Ser Ala Met Pro Ser Ile Leu Ala Thr Ser Trp
     210                 215                 220                
 Gln Ala Ser Val Xaa Ala Ser Cys Lys Arg Leu Ser Ser Ser Gln Ala
 225                 230                 235                 240
 Ser Ser Glu Glu Ser Gly Pro Asp Gly Leu Pro Ala Val Ser Glu Asp
                 245                 250                 255    
 Trp Val Trp Ser Ala Asn Val Ala Ser Ala Leu Gln Ser Ser Ser Ser
             260                 265                 270        
 Met Trp Ser Phe Pro Ala Val Thr Glu Arg Leu Gly Glu Ser Val Cys
         275                 280                 285            
 Ser Pro Ser Asp Asp Ser Arg Asp Cys Ser Pro Gly Ala Pro Leu Tyr
     290                 295                 300                
 Val Gly Phe Leu Tyr Leu Thr Leu Cys Arg Asp Lys Phe Tyr Ser Leu
 305                 310                 315                 320
 Lys Met Lys Lys Asn Lys Leu Leu Lys Ile Gln Asn Asn Thr Leu Tyr
                 325                 330                 335    
 Arg Lys Glu Lys Lys Gly His Met Asn Met Cys Asn Thr Ala Ile Phe
             340                 345                 350        





      <210> 2047
      <211> 41
      <212> PRT
      <213> Homo sapiens


      <400> 2047
 Asn Cys Gly Ser Gly Asp Ile Leu Leu Lys Ile Val Lys Val Glu His
   1               5                  10                  15    
 Glu Glu Met Pro Glu Ala Lys Asn Val Ile Ala Val Leu Glu Glu Phe
              20                  25                  30        
 Met Lys Glu Ala Leu Asp Gln Ser Phe
          35                  40    



      <210> 2048
      <211> 462
      <212> PRT
      <213> Homo sapiens


      <400> 2048
 Arg Asp Phe Val Ala Ala Ser Ser Arg Arg Arg Arg Ala Asp Phe Pro
   1               5                  10                  15    
 Arg Met Thr Glu Leu Arg Gln Arg Val Ala His Glu Pro Val Ala Pro
              20                  25                  30        
 Pro Glu Asp Lys Glu Ser Glu Ser Glu Ala Lys Val Asp Gly Glu Thr
          35                  40                  45            
 Ala Ser Asp Ser Glu Ser Arg Ala Glu Ser Ala Pro Leu Pro Val Ser
      50                  55                  60                
 Ala Asp Asp Thr Pro Glu Val Leu Asn Arg Ala Leu Ser Asn Leu Ser
  65                  70                  75                  80
 Ser Arg Trp Lys Asn Trp Trp Val Arg Gly Ile Leu Thr Leu Ala Met
                  85                  90                  95    
 Ile Ala Phe Phe Phe Ile Ile Ile Tyr Leu Gly Pro Met Val Leu Met
             100                 105                 110        
 Ile Ile Val Met Cys Val Gln Ile Lys Cys Phe His Glu Ile Ile Thr
         115                 120                 125            
 Ile Gly Tyr Asn Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr
     130                 135                 140                
 Leu Ser Trp Tyr Phe Leu Leu Ser Val Asn Tyr Phe Phe Tyr Gly Glu
 145                 150                 155                 160
 Thr Val Thr Asp Tyr Phe Phe Thr Leu Val Gln Arg Glu Glu Pro Leu
                 165                 170                 175    
 Arg Ile Leu Ser Lys Tyr His Arg Leu Ile Ser Phe Thr Leu Tyr Leu
             180                 185                 190        
 Ile Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg
         195                 200                 205            
 Leu Gln Phe Tyr Met Phe Gly Trp Thr His Val Thr Leu Leu Ile Val
     210                 215                 220                
 Val Thr Gln Ser His Leu Val Ile His Asn Leu Phe Glu Gly Met Ile
 225                 230                 235                 240
 Trp Phe Ile Val Pro Ile Ser Cys Val Ile Cys Asn Asp Ile Met Ala
                 245                 250                 255    
 Tyr Met Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser
             260                 265                 270        
 Pro Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ala Thr Val
         275                 280                 285            
 Val Phe Gly Leu Leu Leu Ser Tyr Val Met Ser Gly Tyr Arg Cys Phe
     290                 295                 300                
 Val Cys Pro Val Glu Tyr Asn Asn Asp Thr Asn Ser Phe Thr Val Asp
 305                 310                 315                 320
 Cys Glu Pro Ser Asp Leu Phe Arg Leu Gln Glu Tyr Asn Ile Pro Gly
                 325                 330                 335    
 Val Ile Gln Ser Val Ile Gly Trp Lys Thr Val Arg Met Tyr Pro Phe
             340                 345                 350        
 Gln Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro
         355                 360                 365            
 Phe Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys
     370                 375                 380                
 Asp Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe
 385                 390                 395                 400
 Asp Cys Gln Tyr Leu Met Ala Thr Phe Val Asn Val Tyr Ile Ala Ser
                 405                 410                 415    
 Phe Ile Arg Gly Pro Asn Pro Ser Lys Leu Ile Gln Gln Phe Leu Thr
             420                 425                 430        
 Leu Arg Pro Asp Gln Gln Leu His Ile Phe Asn Thr Leu Arg Ser His
         435                 440                 445            
 Leu Ile Asp Lys Gly Met Leu Thr Ser Thr Thr Glu Asp Glu
     450                 455                 460        



      <210> 2049
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 2049
 His Ser Trp Val Ser Arg Ser Cys Ala Phe Glu Pro Ala Trp Glu Glu
   1               5                  10                  15    
 Gly Ala Thr Ser Gln Thr Val Ala Thr Cys Gly Gly Glu Ala Val Cys
              20                  25                  30        
 Val Ile Asp Cys Gln Thr Gly Ile Val Leu His Lys Tyr Lys Ala Pro
          35                  40                  45            
 Gly Glu Glu Phe Phe Ser Val Ala Trp Thr Ala Leu Met Val Val Thr
      50                  55                  60                
 Gln Ala Gly His Lys Lys Arg Trp Ser Val Leu Ala Ala Ala Gly Leu
  65                  70                  75                  80
 Arg Gly Leu Val Arg Leu Leu His Val Arg Ala Gly Phe Cys Cys Gly
                  85                  90                  95    
 Val Ile Arg Ala His Lys Lys Ala Ile Ala Thr Leu Cys Phe Ser Pro
             100                 105                 110        
 Ala His Glu Thr His Leu Phe Thr Ala Ser Tyr Asp Lys Arg Ile Ile
         115                 120                 125            
 Leu Trp Asp Ile Gly Val Pro Asn Gln Asp Tyr Glu Phe Gln
     130                 135                 140        



      <210> 2050
      <211> 297
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(297)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2050
 Arg Thr Arg Gly Arg Thr Arg Gly Arg Gly Thr Arg Gly Gly Gly Gly
   1               5                  10                  15    
 Gly Gly Gly Thr Gly Ala Gly Gly Arg Gly Glu Gly Ser Gln Val Pro
              20                  25                  30        
 Gly Leu Ser Ala Ala Asp Gln Asp Arg Xaa Gly Arg Gly Cys Cys Ser
          35                  40                  45            
 Pro Gly Gly Arg Asp Arg Ala Gly Gly Gly Gly Gly Ile Gly Gln Gly
      50                  55                  60                
 Gly Asp Ala Glu Arg Arg Arg Gly Glu Gln Gly Glu Gly Trp Gly Arg
  65                  70                  75                  80
 Thr Pro Gly Gln Lys Pro Gly Arg Gly Glu Ala Pro Leu Trp Lys Gly
                  85                  90                  95    
 Arg Val Xaa Gly Pro Arg Val Val Arg Gly Gly Pro Glu Ala Ala Gly
             100                 105                 110        
 Ala Ala Ala Ala Gln Arg Pro Pro Gly Pro Val Pro Phe Pro Ala Gly
         115                 120                 125            
 Gly Ala Glu Pro Leu Pro Ala Leu Gln Pro Ile Pro Ala Ala Gln Asp
     130                 135                 140                
 Leu Arg Gly Ala Ala Gln Lys Glu Gly Pro Gly Gly Arg Xaa Gly Gly
 145                 150                 155                 160
 Xaa Pro Gly Arg Arg Gly Arg Gly Pro Arg Glu Arg Ala Ser Val Pro
                 165                 170                 175    
 Ala Pro Ser Gly His Ala Gly Gly Ala Glu Glu Ala Ala Gly Arg Arg
             180                 185                 190        
 Pro Ala Val Val Pro Pro Gly Ala Gly Pro Val Glu Ala Ala Val Pro
         195                 200                 205            
 Gly Glu Ala His Gln Gly Gly Glu Gly Val Ala Thr Leu Pro Gly Thr
     210                 215                 220                
 Gln Glu Ala Gly Gly Asp Ala Gly His Gly Gln Leu Ser Asp Glu Gly
 225                 230                 235                 240
 Arg Ala Pro Gly Cys Ser Ala Arg Gly Gly Ala Asp Pro Gly Val Gly
                 245                 250                 255    
 Gly Xaa Lys Gly Glu Gly Asp Glu Arg Arg Ala Ala Gly Glu His Ser
             260                 265                 270        
 Ala Glu Ala Glu Pro Gly Ala Phe Xaa Asn Gln Asp Glu Asp Pro Gly
         275                 280                 285            
 Gly Pro Asp Pro Gly Ser Ala Ser Tyr
     290                 295        



      <210> 2051
      <211> 363
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(363)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2051
 Phe Val Leu Cys Ala Gly Ala Cys Trp Pro Leu Arg Asp Arg Asp Thr
   1               5                  10                  15    
 Ser Pro Pro Ala His Leu Cys Pro Glu Val Thr Pro Trp Ser Leu His
              20                  25                  30        
 Val Pro Ile Ser Leu Gln Cys Pro Pro Arg Leu Cys Ser Pro Pro Thr
          35                  40                  45            
 His Arg Leu Thr Pro Pro Ala Gly Cys Gln Arg Pro Pro Pro Ala Gly
      50                  55                  60                
 Pro Leu Ser Val Ala Pro Ala Ser Leu Ser Pro Ser Ala Pro Ala Leu
  65                  70                  75                  80
 Leu Glu Ala Thr Ser Pro Pro Trp Thr Ala Gly Ala Thr Trp Ser Pro
                  85                  90                  95    
 Gly Arg Ser Pro Ala Thr Gln Cys Trp Pro Pro Ser Trp Cys Gln Thr
             100                 105                 110        
 Pro Phe Pro His Pro Glu Thr Gly Gln Leu Cys Leu Val Arg Ser Leu
         115                 120                 125            
 His Xaa Pro His Leu Ser Ser Leu Gly Gln Ala Gly Ala Ala Gly Xaa
     130                 135                 140                
 Gly Gly Pro Leu Ala Pro Pro Phe Pro Pro Phe Leu Val Pro Phe Pro
 145                 150                 155                 160
 Pro Xaa Gln Val Gln His Pro Arg Ser Pro Ala Xaa Gly Ala Gly Pro
                 165                 170                 175    
 Glu Pro Ala Val Asn Ile Pro Gln Pro Leu Pro Val Pro Pro Trp Asp
             180                 185                 190        
 Xaa Pro Leu Thr Ser Pro Pro Asn Ser Thr Gly Ala Pro Ser Trp Pro
         195                 200                 205            
 Arg Ala Gly Ser Val Ser Pro Ser Pro Val Leu Glu Pro Arg Pro Glu
     210                 215                 220                
 Gln Leu Ser Gly Arg Gln Gly Cys Ser Ser Val Ser Ser Trp Gly Ala
 225                 230                 235                 240
 Pro Gly Gly Ala Thr Asp Arg Gln Ala Ala Gln Gly Pro Gly His Pro
                 245                 250                 255    
 Ser Pro Gly Arg Cys Cys Pro Arg Arg Thr Val Leu Gly Asn Glu Pro
             260                 265                 270        
 Pro Ala Gly Phe Gly Leu Arg Ser Leu Trp Pro Arg Ser Pro Pro His
         275                 280                 285            
 Glu Val Gly Ala Arg Leu Pro Asn Gly Ala Phe Gly Phe Ser Val Arg
     290                 295                 300                
 Cys Leu Leu Cys Phe Pro Pro Trp Arg Ala Glu Pro Pro His Ile Arg
 305                 310                 315                 320
 Ile Gly Arg Ala Thr Pro Pro Gly Pro Gly Pro Val Pro Ser Gln Pro
                 325                 330                 335    
 Ser Pro Arg Gly Ser Met Pro Val Pro Arg Pro Gly Ala Ala Arg Gly
             340                 345                 350        
 Gln Leu Asp Gly His Val Gln Gly Ser Arg Leu
         355                 360            



      <210> 2052
      <211> 460
      <212> PRT
      <213> Homo sapiens


      <400> 2052
 Lys Tyr Glu Ser Ala Gln Pro Gly Gly Thr Gln Pro Glu Pro Gly Leu
   1               5                  10                  15    
 Gly Ala Arg Met Ala Ile His Lys Ala Leu Val Met Cys Leu Gly Leu
              20                  25                  30        
 Pro Leu Phe Leu Phe Pro Gly Ala Trp Ala Gln Gly His Val Pro Pro
          35                  40                  45            
 Gly Cys Ser Gln Gly Leu Asn Pro Leu Tyr Tyr Asn Leu Cys Asp Arg
      50                  55                  60                
 Ser Gly Ala Trp Gly Ile Val Leu Glu Ala Val Ala Gly Ala Gly Ile
  65                  70                  75                  80
 Val Thr Thr Phe Val Leu Thr Ile Ile Leu Val Ala Ser Leu Pro Phe
                  85                  90                  95    
 Val Gln Asp Thr Lys Lys Arg Ser Leu Leu Gly Thr Gln Val Phe Phe
             100                 105                 110        
 Leu Leu Gly Thr Leu Gly Leu Phe Cys Leu Val Phe Ala Cys Val Glu
         115                 120                 125            
 Lys Pro Asp Phe Ser Thr Cys Ala Ser Arg Arg Phe Leu Phe Gly Val
     130                 135                 140                
 Leu Phe Ala Ile Cys Phe Ser Cys Leu Ala Ala His Val Phe Ala Leu
 145                 150                 155                 160
 Asn Phe Leu Ala Arg Lys Asn His Gly Pro Arg Gly Trp Val Ile Phe
                 165                 170                 175    
 Thr Val Ala Leu Leu Leu Thr Leu Val Glu Val Ile Ile Asn Thr Glu
             180                 185                 190        
 Trp Leu Ile Ile Thr Leu Val Arg Gly Ser Gly Glu Gly Gly Pro Gln
         195                 200                 205            
 Gly Asn Ser Ser Ala Gly Trp Ala Val Ala Ser Pro Cys Ala Ile Ala
     210                 215                 220                
 Asn Met Asp Phe Val Met Ala Leu Ile Tyr Val Met Leu Leu Leu Leu
 225                 230                 235                 240
 Gly Ala Phe Leu Gly Ala Trp Pro Ala Leu Cys Gly Arg Tyr Lys Arg
                 245                 250                 255    
 Trp Arg Lys His Gly Val Phe Val Leu Leu Thr Thr Ala Thr Ser Val
             260                 265                 270        
 Ala Ile Trp Val Val Trp Ile Val Met Tyr Thr Tyr Gly Asn Lys Gln
         275                 280                 285            
 His Asn Ser Pro Thr Trp Asp Asp Pro Thr Leu Ala Ile Ala Leu Ala
     290                 295                 300                
 Ala Asn Ala Trp Ala Phe Val Leu Phe Tyr Val Ile Pro Glu Val Ser
 305                 310                 315                 320
 Gln Val Thr Lys Ser Ser Pro Glu Gln Ser Tyr Gln Gly Asp Met Tyr
                 325                 330                 335    
 Pro Thr Arg Gly Val Gly Tyr Glu Thr Ile Leu Lys Glu Gln Lys Gly
             340                 345                 350        
 Gln Ser Met Phe Val Glu Asn Lys Ala Phe Ser Met Asp Glu Pro Val
         355                 360                 365            
 Ala Ala Lys Arg Pro Val Ser Pro Tyr Ser Gly Tyr Asn Gly Gln Leu
     370                 375                 380                
 Leu Thr Ser Val Tyr Gln Pro Thr Glu Met Ala Leu Met His Lys Val
 385                 390                 395                 400
 Pro Ser Glu Gly Ala Tyr Asp Ile Ile Leu Pro Arg Ala Thr Ala Asn
                 405                 410                 415    
 Ser Gln Val Met Gly Ser Ala Asn Ser Thr Leu Arg Ala Glu Asp Met
             420                 425                 430        
 Tyr Ser Ala Gln Ser His Gln Ala Ala Thr Pro Pro Lys Asp Gly Lys
         435                 440                 445            
 Asn Ser Gln Val Phe Arg Asn Pro Tyr Val Trp Asp
     450                 455                 460



      <210> 2053
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 2053
 Met Ala Ser Pro Ala Ala Ser Ser Val Arg Pro Pro Arg Pro Lys Lys
   1               5                  10                  15    
 Glu Pro Gln Thr Leu Val Ile Pro Lys Asn Ala Ala Glu Glu Gln Lys
              20                  25                  30        
 Leu Lys Leu Glu Arg Leu Met Lys Asn Pro Asp Lys Ala Val Pro Ile
          35                  40                  45            
 Pro Glu Lys Met Ser Glu Trp Ala Pro Arg Pro Pro Pro Glu Phe Val
      50                  55                  60                
 Arg Asp Val Met Gly Ser Ser Ala Gly Ala Gly Ser Gly Glu Phe His
  65                  70                  75                  80
 Val Tyr Arg His Leu Arg Arg Arg Glu Tyr Gln Arg Gln Asp Tyr Met
                  85                  90                  95    
 Asp Ala Met Ala Glu Lys Gln Lys Leu Asp Ala Glu Phe Gln Lys Arg
             100                 105                 110        
 Leu Glu Lys Asn Lys Ile Ala Ala Glu Glu Gln Thr Ala Lys Arg Arg
         115                 120                 125            
 Lys Lys Arg Gln Lys Leu Lys Glu Lys Lys Leu Leu Ala Lys Lys Met
     130                 135                 140                
 Lys Leu Glu Gln Lys Lys Gln Glu Gly Pro Gly Gln Pro Lys Glu Gln
 145                 150                 155                 160
 Gly Ser Ser Ser Ser Ala Glu Ala Ser Gly Thr Glu Glu Glu Glu Glu
                 165                 170                 175    
 Val Pro Ser Phe Thr Met Gly Arg
             180                



      <210> 2054
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 2054
 His Glu Lys Met Ala Ala Ala Trp Gly Ser Ser Leu Thr Ala Ala Thr
   1               5                  10                  15    
 Gln Arg Ala Val Thr Pro Trp Pro Arg Gly Arg Leu Leu Thr Ala Ser
              20                  25                  30        
 Leu Gly Pro Gln Ala Arg Arg Glu Ala Ser Ser Ser Ser Pro Glu Ala
          35                  40                  45            
 Gly Glu Gly Gln Ile Arg Leu Thr Asp Ser Cys Val Gln Arg Leu Leu
      50                  55                  60                
 Glu Ile Thr Glu Gly Ser Glu Phe Leu Arg Leu Gln Val Glu Gly Gly
  65                  70                  75                  80
 Gly Cys Ser Gly Phe Gln Tyr Lys Phe Ser Leu Asp Thr Val Ile Asn
                  85                  90                  95    
 Pro Asp Asp Arg Val Phe Glu Gln Gly Gly Ala Arg Val Val Val Asp
             100                 105                 110        
 Ser Asp Ser Leu Ala Phe Val Lys Gly Ala Gln Val Asp Phe Ser Gln
         115                 120                 125            
 Glu Leu Ile Arg Ser Ser Phe Gln Val Leu Asn Asn Pro Gln Ala Gln
     130                 135                 140                
 Gln Gly Cys Ser Cys Gly Ser Ser Phe Ser Ile Lys Leu
 145                 150                 155        



      <210> 2055
      <211> 321
      <212> PRT
      <213> Homo sapiens


      <400> 2055
 Thr His Val Val Met Thr Gly Met Cys Tyr Ala Pro His Gln Val Leu
   1               5                  10                  15    
 Ser Tyr Ile Asn Gly Val Thr Thr Ser Lys Pro Gly Val Ser Leu Val
              20                  25                  30        
 Tyr Ser Met Pro Ser Arg Asn Leu Ser Leu Arg Leu Glu Gly Leu Gln
          35                  40                  45            
 Glu Lys Asp Ser Gly Pro Tyr Ser Cys Ser Val Asn Val Gln Asp Lys
      50                  55                  60                
 Gln Gly Lys Ser Arg Gly His Ser Ile Lys Thr Leu Glu Leu Asn Val
  65                  70                  75                  80
 Leu Val Pro Pro Ala Pro Pro Ser Cys Arg Leu Gln Gly Val Pro His
                  85                  90                  95    
 Val Gly Ala Asn Val Thr Leu Ser Cys Gln Ser Pro Arg Ser Lys Pro
             100                 105                 110        
 Ala Val Gln Tyr Gln Trp Asp Arg Gln Leu Pro Ser Phe Gln Thr Phe
         115                 120                 125            
 Phe Ala Pro Ala Leu Asp Val Ile Arg Gly Ser Leu Ser Leu Thr Asn
     130                 135                 140                
 Leu Ser Ser Ser Met Ala Gly Val Tyr Val Cys Lys Ala His Asn Glu
 145                 150                 155                 160
 Val Gly Thr Ala Gln Cys Asn Val Thr Leu Glu Val Ser Thr Gly Pro
                 165                 170                 175    
 Gly Ala Ala Val Val Ala Gly Ala Val Val Gly Thr Leu Val Gly Leu
             180                 185                 190        
 Gly Leu Leu Ala Gly Leu Val Leu Leu Tyr His Arg Arg Gly Lys Ala
         195                 200                 205            
 Leu Glu Glu Pro Ala Asn Asp Ile Lys Glu Asp Ala Ile Ala Pro Arg
     210                 215                 220                
 Thr Leu Pro Trp Pro Lys Ser Ser Asp Thr Ile Ser Lys Asn Gly Thr
 225                 230                 235                 240
 Leu Ser Ser Val Thr Ser Ala Arg Ala Leu Arg Pro Pro His Gly Pro
                 245                 250                 255    
 Pro Arg Pro Gly Ala Leu Thr Pro Thr Pro Ser Leu Ser Ser Gln Ala
             260                 265                 270        
 Leu Pro Ser Pro Arg Leu Pro Thr Thr Asp Gly Ala His Pro Gln Pro
         275                 280                 285            
 Ile Ser Pro Ile Pro Gly Gly Val Ser Ser Ser Gly Leu Ser Arg Met
     290                 295                 300                
 Gly Ala Val Pro Val Met Val Pro Ala Gln Ser Gln Ala Gly Ser Leu
 305                 310                 315                 320
 Val
    



      <210> 2056
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 2056
 Val Val Glu Phe Pro Val Leu Thr Lys Ala Ala Thr Ser Gly Ile Leu
   1               5                  10                  15    
 Ser Ala Leu Gly Asn Phe Leu Ala Gln Met Ile Glu Lys Lys Arg Lys
              20                  25                  30        
 Lys Glu Asn Ser Arg Ser Leu Asp Val Gly Gly Pro Leu Arg Tyr Ala
          35                  40                  45            
 Val Tyr Gly Phe Phe Phe Thr Gly Pro Leu Ser His Phe Phe Tyr Phe
      50                  55                  60                
 Phe Met Glu His Trp Ile Pro Pro Glu Val Pro Leu Ala Gly Leu Arg
  65                  70                  75                  80
 Arg Leu Leu Leu Asp Arg Leu Val Phe Ala Pro Ala Phe Leu Met Leu
                  85                  90                  95    
 Phe Phe Leu Ile Met Asn Phe Leu Glu Gly Lys Asp Ala Ser Ala Phe
             100                 105                 110        
 Ala Ala Lys Met Arg Gly Gly Phe Trp Pro Ala Leu Arg Met Asn Trp
         115                 120                 125            
 Arg Val Trp Thr Pro Leu Gln Phe Ile Asn Ile Asn Tyr Val Pro Leu
     130                 135                 140                
 Lys Phe Arg Val Leu Phe Ala Asn Leu Ala Ala Leu Phe Trp Tyr Ala
 145                 150                 155                 160
 Tyr Leu Ala Ser Leu Gly Lys
                 165        



      <210> 2057
      <211> 109
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(109)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2057
 His Gly Cys Val Leu Ser Leu Leu Pro Lys Pro Gln Gln Gly Phe Arg
   1               5                  10                  15    
 Glu Pro Val His Leu Thr Ser Thr Cys Pro Asn Pro Thr Pro Pro Val
              20                  25                  30        
 Pro Pro Xaa Ser Asp Arg Tyr Leu Ser Asn Pro Thr Gln Pro Val Pro
          35                  40                  45            
 Pro Xaa Ser Asp Arg Tyr Leu Ser Asn Pro Thr Pro Pro Val Ser Pro
      50                  55                  60                
 Xaa Ser Asp Arg Tyr Leu Ser Asn Pro Thr Pro Pro Val Pro Pro Xaa
  65                  70                  75                  80
 Ser Asp Arg Tyr Leu Ser Asn Arg Thr Pro Pro Val Ser Pro Xaa Ser
                  85                  90                  95    
 Asp Arg Tyr Leu Ser Asn Pro Thr Pro Pro Val Ser Pro
             100                 105                



      <210> 2058
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 2058
 Asp Thr Gly Gln Lys Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Tyr
   1               5                  10                  15    
 Gly Ser Gln Gly Ile Lys Gly Glu Gln Gly Pro Gln Gly Phe Pro Gly
              20                  25                  30        
 Pro Lys Gly Thr Met Gly His Gly Leu Pro Gly Gln Lys Gly Glu His
          35                  40                  45            
 Gly Glu Arg Gly Asp Val Gly Lys Lys Gly Asp Lys Gly Glu Ile Gly
      50                  55                  60                
 Glu Pro Gly Ser Pro Gly Lys Gln Gly Leu Gln Gly Pro Lys Gly Asp
  65                  70                  75                  80
 Leu Gly Leu Thr Lys Glu Glu Ile Ile Lys Leu Ile Thr Glu Ile Cys
                  85                  90                  95    
 Gly Cys Gly Pro Lys Cys Lys Glu Thr Pro Leu Glu Leu Val Phe Val
             100                 105                 110        
 Ile Asp Ser Ser Glu Ser Val Gly Pro Glu Asn Phe Gln Ile Ile Lys
         115                 120                 125            
 Asn Phe Val Lys Thr Met Ala Asp Arg Val Ala Leu Asp Leu Ala Thr
     130                 135                 140                
 Ala Arg Ile Gly Ile Ile Asn Tyr Ser His Lys Val Glu Lys Val
 145                 150                 155                



      <210> 2059
      <211> 183
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(183)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2059
 Val Phe Leu Tyr Pro Phe Leu Lys Trp Trp Arg Asp Pro Xaa Arg Arg
   1               5                  10                  15    
 Glu Leu Pro Thr Phe His Trp Phe Leu Leu Glu Leu Ala Ile Phe Thr
              20                  25                  30        
 Leu Ile Glu Glu Val Leu Phe Tyr Tyr Ser His Arg Leu Leu His His
          35                  40                  45            
 Pro Thr Phe Tyr Lys Lys Ile His Lys Lys His His Glu Trp Thr Ala
      50                  55                  60                
 Pro Ile Gly Val Ile Ser Leu Tyr Ala His Pro Ile Glu His Ala Val
  65                  70                  75                  80
 Ser Asn Met Leu Pro Val Ile Val Gly Pro Leu Val Met Gly Ser His
                  85                  90                  95    
 Leu Ser Ser Ile Thr Met Trp Phe Ser Leu Ala Leu Ile Ile Thr Thr
             100                 105                 110        
 Ile Ser His Cys Gly Tyr His Leu Pro Phe Leu Pro Ser Pro Glu Phe
         115                 120                 125            
 His Asp Tyr His His Leu Lys Phe Asn Gln Cys Tyr Gly Val Leu Gly
     130                 135                 140                
 Val Leu Asp His Leu His Gly Thr Asp Thr Met Phe Lys Gln Thr Lys
 145                 150                 155                 160
 Ala Tyr Glu Arg His Val Leu Leu Leu Gly Phe Thr Pro Leu Ser Glu
                 165                 170                 175    
 Ser Ile Pro Asp Ser Pro Lys
             180            



      <210> 2060
      <211> 239
      <212> PRT
      <213> Homo sapiens


      <400> 2060
 Glu Arg Val Gly Asn Val Cys Ser Leu Glu Ile Ser Asn Ile Gln Lys
   1               5                  10                  15    
 Gly Glu Gly Gly Glu Tyr Met Cys His Ala Val Asn Ile Ile Gly Glu
              20                  25                  30        
 Ala Lys Ser Phe Ala Asn Val Asp Ile Met Pro Gln Arg Arg Lys Ser
          35                  40                  45            
 Gly Gly Thr Thr Thr Ser Arg Ile Phe Val Asp Pro Asn Met Asp Ser
      50                  55                  60                
 Arg Glu Gly Glu Asp Lys Glu Leu Lys Ile Asp Leu Glu Val Phe Glu
  65                  70                  75                  80
 Met Pro Pro Arg Phe Ile Met Pro Ile Cys Asp Phe Lys Ile Pro Glu
                  85                  90                  95    
 Asn Ser Asp Ala Val Phe Lys Cys Ser Val Ile Gly Ile Pro Thr Pro
             100                 105                 110        
 Glu Val Lys Trp Tyr Lys Glu Tyr Met Cys Ile Glu Pro Asp Asn Ile
         115                 120                 125            
 Lys Tyr Val Ile Ser Glu Glu Lys Gly Ser His Thr Leu Lys Ile Arg
     130                 135                 140                
 Asn Val Cys Leu Ser Asp Ser Ala Thr Tyr Arg Cys Arg Ala Val Asn
 145                 150                 155                 160
 Cys Val Gly Glu Ala Ile Cys Arg Gly Phe Leu Thr Met Gly Asp Ser
                 165                 170                 175    
 Glu Ile Phe Ala Val Ile Ala Lys Lys Ser Lys Val Thr Leu Ser Ser
             180                 185                 190        
 Leu Met Glu Glu Leu Val Leu Lys Ser Asn Tyr Thr Asp Ser Phe Phe
         195                 200                 205            
 Glu Phe Gln Val Gly Glu Gly Pro Pro Arg Phe Ile Lys Gly Ile Ser
     210                 215                 220                
 Asp Cys Tyr Ala Pro Ile Gly Thr Ala Ala Tyr Phe Gln Cys Leu
 225                 230                 235                



      <210> 2061
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 2061
 Arg Val Arg Leu Arg Pro Val Phe Cys Val Met Thr Ser Gln Glu Lys
   1               5                  10                  15    
 Thr Glu Glu Tyr Pro Phe Ala Asp Ile Phe Asp Glu Asp Glu Thr Glu
              20                  25                  30        
 Arg Asn Phe Leu Leu Ser Lys Pro Val Cys Phe Val Val Phe Gly Lys
          35                  40                  45            
 Pro Gly Val Gly Lys Thr Thr Leu Ala Arg Tyr Ile Thr Gln Ala Trp
      50                  55                  60                
 Lys Cys Ile Arg Val Glu Ala Leu Pro Ile Leu Glu Glu Gln Ile Ala
  65                  70                  75                  80
 Ala Glu Thr Glu Ser Gly Val Met Leu Gln Ser Met Leu Ile Ser Gly
                  85                  90                  95    
 Gln Ser Ile Pro Asp Glu Leu Val Ile Lys Leu Met Leu Glu Lys Leu
             100                 105                 110        
 Asn Ser Pro Glu Val Cys His Phe Gly Tyr Ile Ile Thr Glu Ile Pro
         115                 120                 125            
 Ser Leu Ser Gln Asp Ala Met Thr Thr Leu Gln Gln Ile Glu Leu Ile
     130                 135                 140                
 Lys Asn Leu Asn Leu Lys Pro Asp Val Ile Ile Asn Ile Lys Gly Val
 145                 150                 155                 160
 Leu Asp Phe
            



      <210> 2062
      <211> 322
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(322)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2062
 Arg Ala Arg Ser Gly Leu Gln Gly Ala Val Pro Leu Gly Pro Thr Gly
   1               5                  10                  15    
 Arg Ser Arg His Ser Leu Gln Thr Lys Leu Pro Ser Ser Pro Phe Ser
              20                  25                  30        
 Glu Arg Pro Leu Val Phe Gln Thr Pro Gly Ala Leu Val Ser Thr Pro
          35                  40                  45            
 His Gly Arg Tyr Pro Pro Pro Leu Cys Pro Pro Lys Ala Ala Phe Gln
      50                  55                  60                
 Lys Val Ile His Gly Lys Ala Val Pro Ser Asn Pro Ser Val Val Pro
  65                  70                  75                  80
 Thr Ala Ile Val Asn Pro Val Arg Ser Thr Ala Gly Pro Gly Thr Leu
                  85                  90                  95    
 Gly Gln Gly Ser Leu Arg Lys Gly Arg Ser Ser Met Arg Lys Asn Gly
             100                 105                 110        
 Ser Leu Gln Arg Pro Leu Gln Ser Gly Ile Pro Thr Leu Val Val Gly
         115                 120                 125            
 Ser Leu Arg Arg Ser Pro Thr Met Gly Pro Ser Ala Ser Ala Val Pro
     130                 135                 140                
 Ile Leu Pro Ala Thr Gly Asp Pro Leu Leu Pro Leu Ser Arg Gly Gly
 145                 150                 155                 160
 Gly Asp Gly Val Gln Ala Ser Pro Ser Arg Gly Ser Pro Pro Ser Arg
                 165                 170                 175    
 Ala Ser Ala Gly Ala Val Arg Pro Gly Ser Thr Pro Arg Pro Ala Pro
             180                 185                 190        
 Ser Leu Trp Lys Thr Lys Lys Ser Pro Ser Arg Val Ser Leu Cys Gln
         195                 200                 205            
 Asn Arg Pro His Leu Pro His His Pro Ser Trp Xaa Asn Gln Lys Thr
     210                 215                 220                
 Gln Glu Met Ala Ser Lys Ser Lys Ser Lys Pro Xaa Asp Phe Arg Ile
 225                 230                 235                 240
 Thr Ala Leu Leu Pro Pro Asn Ile Thr Pro Pro Ile Pro Pro Pro Ala
                 245                 250                 255    
 Lys Pro Glu Gln Pro Ala Thr Leu Lys Ala Ser Gln Pro Glu Ala Ala
             260                 265                 270        
 Ser Leu Gly Pro Glu Met Thr Val Leu Phe Ala His Arg Ser Gly Cys
         275                 280                 285            
 His Ser Gly Gln Gln Thr Asp Leu Arg Arg Lys Ser Ala Leu Gly Lys
     290                 295                 300                
 Ala Thr Thr Leu Val Ser Thr Ala Ser Gly Thr Gln Thr Val Phe Pro
 305                 310                 315                 320
 Ser Lys
        



      <210> 2063
      <211> 322
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(322)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2063
 Arg Ala Arg Ser Gly Leu Gln Gly Ala Val Pro Leu Gly Pro Thr Gly
   1               5                  10                  15    
 Arg Ser Arg His Ser Leu Gln Thr Lys Leu Pro Ser Ser Pro Phe Ser
              20                  25                  30        
 Glu Arg Pro Leu Val Phe Gln Thr Pro Gly Ala Leu Val Ser Thr Pro
          35                  40                  45            
 His Gly Arg Tyr Pro Pro Pro Leu Cys Pro Pro Lys Ala Ala Phe Gln
      50                  55                  60                
 Lys Val Ile His Gly Lys Ala Val Pro Ser Asn Pro Ser Val Val Pro
  65                  70                  75                  80
 Thr Ala Ile Val Asn Pro Val Arg Ser Thr Ala Gly Pro Gly Thr Leu
                  85                  90                  95    
 Gly Gln Gly Ser Leu Arg Lys Gly Arg Ser Ser Met Arg Lys Asn Gly
             100                 105                 110        
 Ser Leu Gln Arg Pro Leu Gln Ser Gly Ile Pro Thr Leu Val Val Gly
         115                 120                 125            
 Ser Leu Arg Arg Ser Pro Thr Met Gly Pro Ser Ala Ser Ala Val Pro
     130                 135                 140                
 Ile Leu Pro Ala Thr Gly Asp Pro Leu Leu Pro Leu Ser Arg Gly Gly
 145                 150                 155                 160
 Gly Asp Gly Val Gln Ala Ser Pro Ser Arg Gly Ser Pro Pro Ser Arg
                 165                 170                 175    
 Ala Ser Ala Gly Ala Val Arg Pro Gly Ser Thr Pro Arg Pro Ala Pro
             180                 185                 190        
 Ser Leu Trp Lys Thr Lys Lys Ser Pro Ser Arg Val Ser Leu Cys Gln
         195                 200                 205            
 Asn Arg Pro His Leu Pro His His Pro Ser Trp Xaa Asn Gln Lys Thr
     210                 215                 220                
 Gln Glu Met Ala Ser Lys Ser Lys Ser Lys Pro Xaa Asp Phe Arg Ile
 225                 230                 235                 240
 Thr Ala Leu Leu Pro Pro Asn Ile Thr Pro Pro Ile Pro Pro Pro Ala
                 245                 250                 255    
 Lys Pro Glu Gln Pro Ala Thr Leu Lys Ala Ser Gln Pro Glu Ala Ala
             260                 265                 270        
 Ser Leu Gly Pro Glu Met Thr Val Leu Phe Ala His Arg Ser Gly Cys
         275                 280                 285            
 His Ser Gly Gln Gln Thr Asp Leu Arg Arg Lys Ser Ala Leu Gly Lys
     290                 295                 300                
 Ala Thr Thr Leu Val Ser Thr Ala Ser Gly Thr Gln Thr Val Phe Pro
 305                 310                 315                 320
 Ser Lys
        



      <210> 2064
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 2064
 Glu Phe Val Met Arg His Lys Gly Ala Lys His Leu Arg Ser Ala Ala
   1               5                  10                  15    
 His Asp Leu Thr Trp Phe Gln His Tyr Ser Ile Asp Val Ile Gly Phe
              20                  25                  30        
 Leu Leu Thr Cys Val Ala Thr Ala Ile Phe Leu Phe Thr Lys Cys Phe
          35                  40                  45            
 Leu Phe Ser Cys Gln Lys Phe Asn Lys Thr Arg Lys Ile Glu Lys Arg
      50                  55                  60                
 Glu
  65



      <210> 2065
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 2065
 His Glu Gly Ala Ser Leu Gly Val Arg Gly Gly Gly Met Ala Asp Thr
   1               5                  10                  15    
 Val Leu Phe Glu Phe Leu His Thr Glu Met Val Ala Glu Leu Trp Ala
              20                  25                  30        
 His Asp Pro Asp Pro Gly Pro Gly Gly Gln Lys Met Ser Leu Ser Val
          35                  40                  45            
 Leu Glu Gly Met Gly Phe Arg Val Gly Gln Ala Leu Gly Glu Arg Leu
      50                  55                  60                
 Pro Arg Glu Thr Leu Ala Phe Arg Glu Glu Leu Asp Val Leu Lys Phe
  65                  70                  75                  80
 Leu Cys Lys Asp Leu Trp Val Ala Val Phe Gln Lys Gln Met Asp Ser
                  85                  90                  95    
 Leu Arg Thr Asn His Gln Gly Thr Tyr Val Leu Gln Asp Asn Ser Phe
             100                 105                 110        
 Pro Leu Leu Leu Pro Met Ala Ser Gly Leu Gln Tyr Leu Glu Glu Ala
         115                 120                 125            
 Pro Lys Phe Leu Ala Phe Thr Cys Gly Leu Leu Arg Gly Ala Leu Tyr
     130                 135                 140                
 Thr Leu Gly Ile Glu Ser Val Val Thr Ala Ser Val Ala Ala Leu Pro
 145                 150                 155                 160
 Val Cys Lys Phe Gln Val Val Ile Pro Lys Ser
                 165                 170    



      <210> 2066
      <211> 186
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(186)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2066
 Ile Ile Phe Ile Tyr Leu Phe Ile Phe Leu Arg Trp Ser Leu Gly Ser
   1               5                  10                  15    
 Val Ala Gln Ala Glu Val Gln Trp Pro His Leu Asn Ser Leu Gln Ala
              20                  25                  30        
 Pro Pro Pro Gly Phe Ala Pro Phe Ser Cys Leu Arg Leu Pro Ser Ser
          35                  40                  45            
 Trp Asp Tyr Arg His Leu Pro Pro Cys Pro Ala Asn Phe Leu Tyr Phe
      50                  55                  60                
 Trp Trp Arg Arg Gly Phe Thr Met Leu Ala Arg Met Val Leu Ile Ser
  65                  70                  75                  80
 Xaa Pro Arg Asp Pro Pro Ala Ser Ala Ser Gln Gly Ala Gly Ile Ala
                  85                  90                  95    
 Gly Met Ser His Cys Ala Arg Pro Xaa Met Asn Tyr Phe Tyr Leu Phe
             100                 105                 110        
 Ile Tyr Phe Phe Glu Met Glu Ser Arg Ser Val Ala Gln Ala Glu Val
         115                 120                 125            
 Gln Trp Pro His Leu Asn Ser Leu Gln Ala Pro Pro Pro Gly Phe Ala
     130                 135                 140                
 Pro Phe Ser Cys Leu Arg Leu Pro Ser Ser Trp Asp Tyr Arg His Leu
 145                 150                 155                 160
 Pro Pro Cys Pro Ala Asn Phe Leu Tyr Phe Trp Trp Arg Arg Gly Phe
                 165                 170                 175    
 Thr Met Leu Ala Arg Met Val Leu Ile Ser
             180                 185    



      <210> 2067
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 2067
 Pro Gly Gly Asn Arg Ser Ser Ser Ser Ser Cys Arg Arg Cys Ile Cys
   1               5                  10                  15    
 Thr Phe Cys Thr Cys Arg Ser Arg Arg Arg Arg Arg Ser His Gln Pro
              20                  25                  30        
 Arg Arg Ser Ser Trp Gly Pro Leu Gln Ala Glu Val Arg Leu Glu Phe
          35                  40                  45            
 Pro Ser Glu Lys Arg Arg Gly Ser Gly Thr Arg Gly Gly Arg Gly Gly
      50                  55                  60                
 Ser Thr Gly Val Ala Ser Val Gly Ser Ser Thr Trp Gly Gly Thr Pro
  65                  70                  75                  80
 Gly Leu Gly Gln Thr Gly Thr Trp Gln Gly His Thr Gly Gln Arg Gly
                  85                  90                  95    
 Pro Gln Leu Pro Pro His Pro Arg Asn Ser Phe Ser Ser Arg His Arg
             100                 105                 110        
 Gly Ser Ser Gly Arg Leu Ser Gln Ala Leu Pro Glu Pro Arg Gly Leu
         115                 120                 125            
 Glu Ser Gly Lys Thr Gly Ser Ala Arg Gly Val Ala Ala Gly Arg His
     130                 135                 140                
 Gln Glu Gly Glu Ala Ala Thr Gly Gly Gly Pro Arg Asp Ile Ala Gln
 145                 150                 155                 160
 Gln Gly Gly Cys Arg Gly Ser Ala Cys Gly Arg Arg Ser His Glu Ala
                 165                 170                 175    
 Leu Arg Pro Arg Val Trp Cys Gly Glu Gly Pro Gln Trp Thr Trp Cys
             180                 185                 190        
 Ala Val Cys Pro His Arg Ser Ala Pro Gly Ala Gly Leu Ala Asp Arg
         195                 200                 205            
 Gln His Pro Gly Glu Ser Arg Ala Trp Gly Glu Thr Arg Leu Gly Glu
     210                 215                 220                
 Ala Gly Gly Ala Glu
 225                



      <210> 2068
      <211> 305
      <212> PRT
      <213> Homo sapiens


      <400> 2068
 Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr
   1               5                  10                  15    
 Ser Ile Ala Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu
              20                  25                  30        
 Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr
          35                  40                  45            
 Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile
      50                  55                  60                
 Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val
  65                  70                  75                  80
 Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu
                  85                  90                  95    
 Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys
             100                 105                 110        
 Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala
         115                 120                 125            
 Ser Thr Pro Ala Pro Thr Thr Pro Thr Ser Thr Thr Phe Thr Ala Pro
     130                 135                 140                
 Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His His
 145                 150                 155                 160
 Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro Leu
                 165                 170                 175    
 Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu Ala
             180                 185                 190        
 Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro Glu
         195                 200                 205            
 Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu Thr
     210                 215                 220                
 Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu Ser
 225                 230                 235                 240
 Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala Ser
                 245                 250                 255    
 Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala Glu
             260                 265                 270        
 Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His Leu
         275                 280                 285            
 Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser Arg
     290                 295                 300                
 Pro
 305



      <210> 2069
      <211> 305
      <212> PRT
      <213> Homo sapiens


      <400> 2069
 Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr
   1               5                  10                  15    
 Ser Ile Ala Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu
              20                  25                  30        
 Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr
          35                  40                  45            
 Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile
      50                  55                  60                
 Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val
  65                  70                  75                  80
 Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu
                  85                  90                  95    
 Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys
             100                 105                 110        
 Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala
         115                 120                 125            
 Ser Thr Pro Ala Pro Thr Thr Pro Thr Ser Thr Thr Phe Thr Ala Pro
     130                 135                 140                
 Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His His
 145                 150                 155                 160
 Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro Leu
                 165                 170                 175    
 Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu Ala
             180                 185                 190        
 Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro Glu
         195                 200                 205            
 Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu Thr
     210                 215                 220                
 Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu Ser
 225                 230                 235                 240
 Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala Ser
                 245                 250                 255    
 Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala Glu
             260                 265                 270        
 Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His Leu
         275                 280                 285            
 Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser Arg
     290                 295                 300                
 Pro
 305



      <210> 2070
      <211> 305
      <212> PRT
      <213> Homo sapiens


      <400> 2070
 Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr
   1               5                  10                  15    
 Ser Ile Ala Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu
              20                  25                  30        
 Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr
          35                  40                  45            
 Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile
      50                  55                  60                
 Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val
  65                  70                  75                  80
 Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu
                  85                  90                  95    
 Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys
             100                 105                 110        
 Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala
         115                 120                 125            
 Ser Thr Pro Ala Pro Thr Thr Pro Thr Ser Thr Thr Phe Thr Ala Pro
     130                 135                 140                
 Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His His
 145                 150                 155                 160
 Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro Leu
                 165                 170                 175    
 Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu Ala
             180                 185                 190        
 Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro Glu
         195                 200                 205            
 Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu Thr
     210                 215                 220                
 Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu Ser
 225                 230                 235                 240
 Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala Ser
                 245                 250                 255    
 Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala Glu
             260                 265                 270        
 Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His Leu
         275                 280                 285            
 Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser Arg
     290                 295                 300                
 Pro
 305



      <210> 2071
      <211> 470
      <212> PRT
      <213> Homo sapiens


      <400> 2071
 Ala Leu Pro Gly Glu Phe Phe Phe Arg Phe His Pro Ala His Lys His
   1               5                  10                  15    
 Cys His Leu Leu Pro Pro Ser Leu Phe Thr Asn Val Thr Thr Gln Ser
              20                  25                  30        
 Glu Ile Ser Ser Phe Leu Ser Phe Leu His Phe Gln Gln Val Pro Leu
          35                  40                  45            
 Arg Gln Lys Pro Arg Arg Lys Thr Gln Gly Phe Leu Thr Met Ser Arg
      50                  55                  60                
 Arg Arg Ile Ser Cys Lys Asp Leu Gly His Ala Asp Cys Gln Gly Trp
  65                  70                  75                  80
 Leu Tyr Lys Lys Lys Glu Lys Gly Ser Phe Leu Ser Asn Lys Trp Lys
                  85                  90                  95    
 Lys Phe Trp Val Ile Leu Lys Gly Ser Ser Leu Tyr Trp Tyr Ser Asn
             100                 105                 110        
 Gln Met Ala Glu Lys Ala Asp Gly Phe Val Asn Leu Pro Asp Phe Thr
         115                 120                 125            
 Val Glu Arg Ala Ser Glu Cys Lys Lys Lys His Ala Phe Lys Ile Ser
     130                 135                 140                
 His Pro Gln Ile Lys Thr Phe Tyr Phe Ala Ala Glu Asn Val Gln Glu
 145                 150                 155                 160
 Met Asn Val Trp Leu Asn Lys Leu Gly Ser Ala Val Ile His Gln Glu
                 165                 170                 175    
 Ser Thr Thr Lys Asp Glu Glu Cys Tyr Ser Glu Ser Glu Gln Glu Asp
             180                 185                 190        
 Pro Glu Ile Ala Ala Glu Thr Pro Pro Pro Pro His Ala Ser Gln Thr
         195                 200                 205            
 Gln Ser Leu Thr Ala Gln Gln Ala Ser Ser Ser Ser Pro Ser Leu Ser
     210                 215                 220                
 Gly Thr Ser Tyr Ser Phe Ser Ser Leu Glu Asn Thr Val Lys Thr Pro
 225                 230                 235                 240
 Ser Ser Phe Pro Ser Ser Leu Ser Lys Glu Arg Gln Ser Leu Pro Asp
                 245                 250                 255    
 Thr Val Asn Ser Leu Ser Ala Ala Glu Asp Glu Gly Gln Pro Ile Thr
             260                 265                 270        
 Phe Ala Val Gln Val His Ser Pro Val Pro Ser Glu Ala Gly Ile His
         275                 280                 285            
 Lys Ala Leu Glu Asn Ser Phe Val Thr Ser Glu Ser Gly Phe Leu Asn
     290                 295                 300                
 Ser Leu Ser Ser Asp Asp Thr Ser Ser Leu Ser Ser Asn His Asp His
 305                 310                 315                 320
 Leu Thr Val Pro Asp Lys Pro Ala Gly Ser Lys Ile Met Asp Lys Glu
                 325                 330                 335    
 Glu Thr Lys Val Ser Glu Asp Asp Glu Met Glu Lys Leu Tyr Lys Ser
             340                 345                 350        
 Leu Glu Gln Ala Ser Leu Ser Pro Leu Gly Asp Arg Arg Pro Ser Thr
         355                 360                 365            
 Lys Lys Glu Leu Arg Lys Ser Phe Val Lys Arg Cys Lys Asn Pro Ser
     370                 375                 380                
 Ile Asn Glu Lys Leu His Lys Ile Arg Thr Leu Asn Ser Thr Leu Lys
 385                 390                 395                 400
 Cys Lys Glu His Asp Leu Ala Met Ile Asn Gln Leu Leu Asp Asp Pro
                 405                 410                 415    
 Lys Leu Thr Ala Arg Lys Tyr Arg Glu Trp Lys Val Met Asn Thr Leu
             420                 425                 430        
 Leu Ile Gln Asp Ile Tyr Gln Gln Gln Arg Ala Ser Pro Ala Pro Asp
         435                 440                 445            
 Asp Thr Asp Asp Thr Pro Gln Glu Leu Lys Lys Ser Pro Ser Ser Pro
     450                 455                 460                
 Ser Val Glu Asn Ser Ile
 465                 470



      <210> 2072
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 2072
 Ile Lys Ser Lys Leu Asn Gln Gln Val Glu Val Gln Glu Ser Glu Trp
   1               5                  10                  15    
 Arg Leu Thr Glu Ala Lys Gly Pro Thr Met Gly Lys Glu Ser Gly Trp
              20                  25                  30        
 Asp Ser Gly Arg Ala Ala Val Ala Ala Val Val Gly Gly Val Val Ala
          35                  40                  45            
 Val Gly Thr Val Leu Val Ala Leu Ser Ala Met Gly Phe Thr Ser Val
      50                  55                  60                
 Gly Ile Ala Ala Ser Ser Ile Ala Ala Lys Met Met Ser Thr Ala Ala
  65                  70                  75                  80
 Ile Ala Asn Gly Gly Gly Val Ala Ala Gly Ser Leu Val Ala Ile Leu
                  85                  90                  95    
 Gln Ser Val Gly Ala Ala Gly Leu Ser Val Thr Ser Lys Val Ile Gly
             100                 105                 110        
 Gly Phe Ala Gly Thr Ala Leu Gly Ala Trp Leu Gly Ser Pro Pro Ser
         115                 120                 125            
 Ser
    



      <210> 2073
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 2073
 Ile Lys Ser Lys Leu Asn Gln Gln Val Glu Val Gln Glu Ser Glu Trp
   1               5                  10                  15    
 Arg Leu Thr Glu Ala Lys Gly Pro Thr Met Gly Lys Glu Ser Gly Trp
              20                  25                  30        
 Asp Ser Gly Arg Ala Ala Val Ala Ala Val Val Gly Gly Val Val Ala
          35                  40                  45            
 Val Gly Thr Val Leu Val Ala Leu Ser Ala Met Gly Phe Thr Ser Val
      50                  55                  60                
 Gly Ile Ala Ala Ser Ser Ile Ala Ala Lys Met Met Ser Thr Ala Ala
  65                  70                  75                  80
 Ile Ala Asn Gly Gly Gly Val Ala Ala Gly Ser Leu Val Ala Ile Leu
                  85                  90                  95    
 Gln Ser Val Gly Ala Ala Gly Leu Ser Val Thr Ser Lys Val Ile Gly
             100                 105                 110        
 Gly Phe Ala Gly Thr Ala Leu Gly Ala Trp Leu Gly Ser Pro Pro Ser
         115                 120                 125            
 Ser
    



      <210> 2074
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 2074
 Ala Gly Val Gly Ala Leu Arg Met Val Gln Arg Leu Thr Tyr Arg Arg
   1               5                  10                  15    
 Arg Leu Ser Tyr Asn Thr Ala Ser Asn Lys Thr Arg Leu Ser Arg Thr
              20                  25                  30        
 Pro Gly Asn Arg Ile Val Tyr Leu Tyr Thr Lys Lys Val Gly Lys Ala
          35                  40                  45            
 Pro Lys Ser Ala Cys Gly Val Cys Pro Gly Arg Leu Arg Gly Val Arg
      50                  55                  60                
 Ala Val Arg Pro Lys Val Leu Met Arg Leu Ser Lys Thr Lys Lys His
  65                  70                  75                  80
 Val Ser Arg Ala Tyr Gly Gly Ser Met Cys Ala Lys Cys Val Arg Asp
                  85                  90                  95    
 Arg Ile Lys Arg Ala Phe Leu Ile Glu Glu Gln Lys Ile Val Val Lys
             100                 105                 110        
 Val Leu Lys Ala Gln Ala Gln Ser Gln Lys Ala Lys
         115                 120                



      <210> 2075
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 2075
 Phe Gln Asn Met Thr Cys Glu Leu His Leu Thr Cys Ser Val Glu Asp
   1               5                  10                  15    
 Ala Asp Asp Asn Val Ser Phe Arg Trp Glu Ala Leu Gly Asn Thr Leu
              20                  25                  30        
 Ser Ser Gln Pro Asn Leu Thr Val Ser Trp Asp Pro Arg Ile Ser Ser
          35                  40                  45            
 Glu Gln Asp Tyr Thr Cys Ile Ala Glu Asn Ala Val Ser Asn Leu Ser
      50                  55                  60                
 Phe Ser Val Ser Ala Gln Lys Leu Cys Glu Asp Val Lys Ile Gln Tyr
  65                  70                  75                  80
 Thr Asp Thr Lys Met Ile Leu Phe Met Val Ser Gly Ile Cys Ile Val
                  85                  90                  95    
 Phe Gly Phe Ile Ile Leu Leu Leu Leu Val Leu Arg Lys Arg Arg Asp
             100                 105                 110        
 Ser Leu Ser Leu Ser Thr Gln Arg Thr Gln Gly Pro Ala Glu Ser Ala
         115                 120                 125            
 Arg Asn Leu Glu Tyr Val Ser Val Ser Pro Thr Asn Asn Thr Val Tyr
     130                 135                 140                
 Ala Ser Val Thr
 145            



      <210> 2076
      <211> 322
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(322)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2076
 Val Gly Trp Ser Val His Arg Tyr Val Leu Leu His His Val Met Gly
   1               5                  10                  15    
 Gly Leu Glu Gly Met Gln Gly Ala Trp Gly Tyr Val Gln Gly Gly Met
              20                  25                  30        
 Gly Ala Leu Ser Asp Ala Ile Ala Ser Ser Ala Thr Thr His Gly Ala
          35                  40                  45            
 Ser Ile Phe Thr Glu Lys Thr Val Ala Lys Val Gln Val Asn Ser Glu
      50                  55                  60                
 Gly Cys Val Gln Gly Val Val Leu Glu Asp Gly Thr Glu Val Arg Ser
  65                  70                  75                  80
 Lys Met Val Leu Ser Asn Thr Ser Pro Gln Ile Thr Phe Leu Lys Leu
                  85                  90                  95    
 Thr Pro Gln Glu Trp Leu Pro Glu Glu Phe Leu Glu Arg Ile Ser Gln
             100                 105                 110        
 Leu Asp Thr Arg Ser Pro Val Thr Lys Ile Asn Val Xaa Glu Ala His
         115                 120                 125            
 His Ile Ala Ala Leu Ser Pro Leu Thr His Leu Ser Glu Lys Pro Pro
     130                 135                 140                
 Gly Trp Gly Gln His Glu Leu Ser His His Leu His Cys Pro Asp Leu
 145                 150                 155                 160
 Gln Pro Val Ser Pro Cys Ser Leu Val Arg Ser Gly Arg Arg Gln Ala
                 165                 170                 175    
 Ala Gln Pro Ser Trp Arg Pro Pro Met Leu Pro Gly Ala Ser Arg Cys
             180                 185                 190        
 Pro Ile Thr Asn Ala Pro Ser Thr Xaa Thr Val Lys Thr Pro Ser Ser
         195                 200                 205            
 Phe Ile Arg Pro Leu Lys Met Pro Trp Met Ala Cys Leu Pro Thr Val
     210                 215                 220                
 Phe Asp Cys Ile Glu Val Tyr Ala Pro Gly Phe Lys Asp Ser Val Val
 225                 230                 235                 240
 Gly Arg Asp Ile Leu Thr Pro Pro Asp Leu Glu Arg Ile Phe Gly Leu
                 245                 250                 255    
 Pro Gly Gly Asn Ile Phe His Cys Ala Met Ser Leu Asp Gln Leu Tyr
             260                 265                 270        
 Phe Ala Arg Pro Val Pro Leu His Ser Gly Tyr Arg Cys Pro Leu Gln
         275                 280                 285            
 Gly Leu Tyr Leu Cys Gly Ser Gly Ala His Pro Gly Gly Gly Val Met
     290                 295                 300                
 Gly Ala Ala Gly Arg Asn Ala Ala His Val Ala Phe Arg Asp Leu Lys
 305                 310                 315                 320
 Ser Met
        



      <210> 2077
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 2077
 Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met
   1               5                  10                  15    
 Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr
              20                  25                  30        
 Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile
          35                  40                  45            
 Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His
      50                  55                  60                
 Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu
  65                  70                  75                  80
 Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Leu
                  85                  90                  95    
 Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu
             100                 105                 110        





      <210> 2078
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 2078
 Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met
   1               5                  10                  15    
 Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr
              20                  25                  30        
 Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile
          35                  40                  45            
 Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His
      50                  55                  60                
 Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu
  65                  70                  75                  80
 Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Leu
                  85                  90                  95    
 Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu
             100                 105                 110        





      <210> 2079
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 2079
 Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met
   1               5                  10                  15    
 Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr
              20                  25                  30        
 Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile
          35                  40                  45            
 Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His
      50                  55                  60                
 Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu
  65                  70                  75                  80
 Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Leu
                  85                  90                  95    
 Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu
             100                 105                 110        





      <210> 2080
      <211> 224
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(224)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2080
 Met Ala Pro Pro Leu Arg Pro Leu Ala Arg Leu Arg Pro Pro Gly Met
   1               5                  10                  15    
 Leu Leu Arg Ala Leu Leu Leu Leu Leu Leu Leu Ser Pro Leu Pro Gly
              20                  25                  30        
 Leu Arg Glu Gly Ile Gly Glu Leu Ile Thr Pro Ile Gly Thr Ser Leu
          35                  40                  45            
 Pro Asp Leu Asp Pro Ala Arg Arg Arg Trp Glu Gly Gly Ile Gly Arg
      50                  55                  60                
 Val Gly Ser Glu Val Ala Asp Leu Cys Pro Gly Lys Glu Gly Gly Lys
  65                  70                  75                  80
 Val Pro Glu Ala Glu Lys Glu Gly Val Trp Cys Phe Ser Glu Leu Ser
                  85                  90                  95    
 Phe Val Lys Glu Pro Gln Asp Val Thr Val Thr Arg Lys Asp Pro Val
             100                 105                 110        
 Val Leu Asp Cys Gln Ala His Gly Glu Val Pro Ile Lys Val Thr Trp
         115                 120                 125            
 Leu Lys Asn Gly Ala Lys Met Ser Glu Asn Lys Arg Ile Glu Val Leu
     130                 135                 140                
 Ser Asn Gly Ser Leu Tyr Ile Ser Glu Val Glu Gly Arg Arg Gly Glu
 145                 150                 155                 160
 Gln Ser Asp Glu Gly Phe Tyr Gln Cys Leu Ala Met Asn Lys Phe Xaa
                 165                 170                 175    
 Ala Ile Leu Asn Gln Lys Ala His Leu Ala Leu Ser Arg Ile Gly Ser
             180                 185                 190        
 Thr Xaa Arg Arg Arg Pro Asp Arg Pro Xaa Glu Asp Glu Ala Phe Val
         195                 200                 205            
 Met Thr Thr His Cys Phe Gln Asp Leu Leu Thr Ser Leu Ile Glu Ser
     210                 215                 220                





      <210> 2081
      <211> 1048
      <212> PRT
      <213> Homo sapiens


      <400> 2081
 Met Ala Lys Ile Ser Ala Ser Arg Ala Glu Lys Val Leu Glu His Pro
   1               5                  10                  15    
 Gly Glu Arg Glu Lys Gly Arg Glu Met Ala Ser Pro Trp Asn His Ser
              20                  25                  30        
 Ile Leu Ala Leu Ala Ala Val Val Val Ile Ile Ser Met Val Leu Leu
          35                  40                  45            
 Gly Arg Ser Ile Gln Ala Ser Arg Lys Glu Lys Met Gln Pro Pro Glu
      50                  55                  60                
 Lys Glu Thr Pro Glu Val Leu His Leu Asp Glu Ala Lys Asp His Asn
  65                  70                  75                  80
 Ser Leu Asn Asn Leu Arg Glu Thr Leu Leu Ser Glu Lys Pro Asn Leu
                  85                  90                  95    
 Ala Gln Val Glu Leu Glu Leu Lys Glu Arg Asp Val Leu Ser Val Phe
             100                 105                 110        
 Leu Pro Asp Val Pro Glu Thr Glu Ser Tyr Ile Ser Val Val Asn Met
         115                 120                 125            
 Ala Leu Pro Pro Phe Phe Gly Gln Gly Arg Pro Gly Pro Pro Pro Pro
     130                 135                 140                
 Gln Pro Pro Pro Leu Ala Leu Phe Gly Cys Pro Pro Pro Pro Leu Pro
 145                 150                 155                 160
 Ser Pro Ala Phe Pro Pro Pro Leu Pro Gln Arg Pro Gly Pro Phe Pro
                 165                 170                 175    
 Gly Ala Ser Ala Pro Phe Leu Gln Pro Pro Leu Ala Leu Gln Pro Arg
             180                 185                 190        
 Ala Ser Ala Gln Ala Ser Arg Gly Gly Gly Gly Ala Gly Ala Phe Tyr
         195                 200                 205            
 Pro Val Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Gln Cys Arg Pro
     210                 215                 220                
 Phe Pro Gly Thr Asp Ala Gly Glu Arg Pro Arg Pro Pro Pro Pro Gly
 225                 230                 235                 240
 Pro Gly Pro Pro Trp Ser Pro Arg Trp Pro Glu Ala Pro Pro Pro Pro
                 245                 250                 255    
 Ala Asp Val Leu Gly Asp Ala Ala Leu Gln Arg Leu Arg Asp Arg Gln
             260                 265                 270        
 Trp Leu Glu Ala Val Phe Gly Thr Pro Arg Arg Ala Gly Cys Pro Val
         275                 280                 285            
 Pro Gln Arg Thr His Ala Gly Pro Ser Leu Gly Glu Val Arg Ala Arg
     290                 295                 300                
 Leu Leu Arg Ala Leu Arg Leu Val Arg Arg Leu Arg Gly Leu Ser Gln
 305                 310                 315                 320
 Ala Leu Arg Glu Ala Glu Ala Asp Gly Ala Ala Trp Val Leu Leu Tyr
                 325                 330                 335    
 Ser Gln Thr Ala Pro Leu Arg Ala Glu Leu Ala Glu Arg Leu Gln Pro
             340                 345                 350        
 Leu Thr Gln Ala Ala Tyr Val Gly Glu Ala Arg Arg Arg Leu Glu Arg
         355                 360                 365            
 Val Arg Arg Arg Arg Leu Arg Leu Arg Glu Arg Ala Arg Glu Arg Glu
     370                 375                 380                
 Ala Glu Arg Glu Ala Glu Ala Ala Arg Ala Val Glu Arg Glu Gln Glu
 385                 390                 395                 400
 Ile Asp Arg Trp Arg Val Lys Cys Val Gln Glu Val Glu Glu Lys Lys
                 405                 410                 415    
 Arg Phe Phe Cys Glu Ile Leu Thr Asp Glu Leu Val Leu Trp Glu Pro
             420                 425                 430        
 Ser Gly Arg Pro Gln Pro Gln Gln Leu Gln Ile Leu Thr Ala Met Ser
         435                 440                 445            
 Thr Ser Thr Phe Tyr Asp Lys Glu Leu Lys Thr Ala Arg Glu Asn Lys
     450                 455                 460                
 Glu Glu Glu Leu Ile Asp Lys Leu Glu Val Val Thr Met Pro Ser Pro
 465                 470                 475                 480
 Ser Pro Lys Gly Leu Pro Val Lys Gln Tyr Ala Val Gln Ser Gln Leu
                 485                 490                 495    
 Pro Val Tyr Glu Trp Pro Asp Val Gly Ser Gly Glu Tyr Asp Val Gly
             500                 505                 510        
 Val Val Ala Ser Phe Gly Arg Leu Leu Asn Glu Ala Leu Ile Leu Lys
         515                 520                 525            
 Phe Pro Tyr Ser Ala Leu Gly Gly Ser Gly Ser Pro Ala Pro Leu Thr
     530                 535                 540                
 Arg Leu Ala Ser Pro Ala Ala Pro Gln Asp Gly Gln Val Asp Leu Glu
 545                 550                 555                 560
 Gly Arg Ala Leu Arg Pro Ala Ala Arg Ala Gly Phe Ser Lys His Arg
                 565                 570                 575    
 Gly His Gly Asp Ala Leu Asp Gly His Ala Gly Leu Arg Pro Glu Leu
             580                 585                 590        
 His Ala Pro Leu Thr Val Val Ala Asp Gly Leu Phe Ser Lys Phe Arg
         595                 600                 605            
 Lys Ser Leu Val Ser Asn Lys Val Ser Val Ser Ser His Phe Val Gly
     610                 615                 620                
 Phe Leu Met Lys His Asp Phe Ser Leu Glu Arg Thr Ala Leu Phe Trp
 625                 630                 635                 640
 Val Glu Ala Ala Gly Gln Gly Pro Ser Pro Tyr Gln Cys Gly Asp Pro
                 645                 650                 655    
 Gly Thr Ala Ser Ala Pro Pro Ala Trp Leu Leu Leu Val Ser Pro Glu
             660                 665                 670        
 His Gly Leu Ala Pro Ala Pro Thr Thr Ile Arg Asp Pro Glu Ala Gly
         675                 680                 685            
 His Gln Glu Arg Pro Glu Glu Glu Gly Glu Asp Glu Ala Glu Ala Ser
     690                 695                 700                
 Ser Gly Ser Glu Glu Glu Pro Ala Pro Ser Ser Leu Gln Pro Gly Ser
 705                 710                 715                 720
 Pro Ala Ser Pro Gly Pro Gly Arg Arg Leu Cys Ser Leu Asp Val Leu
                 725                 730                 735    
 Arg Gly Val Arg Leu Glu Leu Ala Gly Ala Arg Arg Arg Leu Ser Glu
             740                 745                 750        
 Gly Lys Leu Val Ser Arg Pro Arg Ala Leu Leu His Gly Leu Arg Gly
         755                 760                 765            
 His Arg Ala Leu Ser Leu Cys Pro Ser Pro Ala Gln Ser Pro Arg Ser
     770                 775                 780                
 Ala Ser Pro Pro Gly Pro Ala Pro Gln His Pro Ala Ala Pro Ala Ser
 785                 790                 795                 800
 Pro Pro Arg Pro Ser Thr Ala Gly Ala Ile Pro Pro Leu Arg Ser His
                 805                 810                 815    
 Lys Pro Thr Val Ala Ile Tyr Ile Thr Thr Lys Arg Leu Pro Tyr Phe
             820                 825                 830        
 Pro Ile Val Asn Phe Leu Phe Leu Ile Ala Gln Leu Pro Lys Leu Gln
         835                 840                 845            
 Tyr Asn Lys Asn Val Ala Leu Thr Val Lys Phe Leu Thr Lys Arg Phe
     850                 855                 860                
 Ile Ser Glu Tyr Asp Pro Asn Leu Gly Met Val Cys Arg Lys Pro Thr
 865                 870                 875                 880
 Asp Pro Val Asp Trp Pro Pro Leu Val Leu Gly Leu Leu Thr Leu Met
                 885                 890                 895    
 Lys Gln Phe His Ser Arg Tyr Thr Glu Gln Phe Leu Ala Leu Ile Gly
             900                 905                 910        
 Gln Phe Ile Cys Ser Thr Val Glu Gln Cys Thr Arg Gln Val Thr Lys
         915                 920                 925            
 Ala Glu Gly Val Ala Leu Ala Gly Arg Phe Gly Cys Leu Phe Phe Glu
     930                 935                 940                
 Val Ser Ala Cys Leu Asp Phe Glu His Val Gln His Val Phe His Glu
 945                 950                 955                 960
 Ala Val Arg Glu Ala Arg Arg Glu Leu Glu Lys Ser Pro Leu Thr Pro
                 965                 970                 975    
 Pro Leu Phe Ile Ser Glu Glu Arg Ala Leu Pro His Gln Ala Pro Leu
             980                 985                 990        
 Thr Ala Arg His Gly Leu Ala Ser Cys Thr Phe Asn Thr Leu Ser Thr
         995                1000                1005            
 Ile Asn Leu Lys Glu Met Pro Thr Val Ala Gln Ala Lys Leu Val Thr
    1010                1015                1020                
 Val Lys Ser Ser Arg Ala Gln Ser Lys Arg Lys Ala Pro Thr Leu Thr
1025                1030                1035                1040
 Leu Leu Lys Gly Phe Lys Ile Phe
                1045            



      <210> 2082
      <211> 251
      <212> PRT
      <213> Homo sapiens


      <400> 2082
 Arg Ser Gly Ser Leu Met Ala Ala Ala Ala Ala Thr Lys Ile Leu Leu
   1               5                  10                  15    
 Cys Leu Pro Leu Leu Leu Leu Leu Ser Gly Trp Ser Arg Ala Gly Arg
              20                  25                  30        
 Ala Asp Pro His Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe
          35                  40                  45            
 Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys
      50                  55                  60                
 Thr Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser
  65                  70                  75                  80
 Pro Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn
                  85                  90                  95    
 Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Arg Asp
             100                 105                 110        
 Ile Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala
         115                 120                 125            
 Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp
     130                 135                 140                
 Gln Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys
 145                 150                 155                 160
 Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys
                 165                 170                 175    
 Trp Glu Asn Asp Lys Val Val Ala Met Ser Phe His Tyr Phe Ser Met
             180                 185                 190        
 Gly Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser
         195                 200                 205            
 Thr Leu Glu Pro Ser Ala Gly Ala Pro Leu Ala Met Ser Ser Gly Thr
     210                 215                 220                
 Thr Gln Leu Arg Ala Thr Ala Thr Thr Leu Ile Leu Cys Cys Leu Leu
 225                 230                 235                 240
 Ile Leu Leu Pro Cys Phe Ile Leu Pro Gly Ile
                 245                 250    



      <210> 2083
      <211> 580
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(580)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2083
 Val Ser Ala Val Glu Phe Val Leu His Gly Lys Asp Phe Gln Val Asp
   1               5                  10                  15    
 Cys Lys Ala Ser Gly Ser Pro Val Pro Xaa Ile Ser Trp Ser Leu Leu
              20                  25                  30        
 Asp Gly Thr Met Ile Asn Asn Ala Met Gln Ala Asp Asp Ser Gly His
          35                  40                  45            
 Arg Thr Arg Arg Tyr Thr Leu Phe Asn Asn Gly Thr Leu Tyr Phe Asn
      50                  55                  60                
 Lys Val Gly Val Ala Glu Glu Gly Asp Tyr Thr Cys Tyr Ala Gln Asn
  65                  70                  75                  80
 Thr Leu Gly Lys Asp Glu Met Lys Val His Leu Thr Val Ile Thr Ala
                  85                  90                  95    
 Ala Pro Arg Ile Arg Gln Ser Asn Lys Thr Asn Lys Arg Ile Lys Ala
             100                 105                 110        
 Gly Asp Thr Ala Val Leu Asp Cys Glu Val Thr Gly Asp Pro Lys Pro
         115                 120                 125            
 Lys Ile Phe Trp Leu Leu Pro Ser Asn Asp Met Ile Ser Phe Ser Ile
     130                 135                 140                
 Asp Arg Tyr Thr Phe His Ala Asn Gly Ser Leu Thr Ile Asn Lys Val
 145                 150                 155                 160
 Lys Leu Leu Asp Ser Gly Glu Tyr Val Cys Val Ala Arg Asn Pro Ser
                 165                 170                 175    
 Gly Asp Asp Thr Lys Met Tyr Lys Leu Asp Val Val Ser Lys Pro Pro
             180                 185                 190        
 Leu Ile Asn Gly Leu Tyr Thr Asn Arg Thr Val Ile Lys Ala Thr Ala
         195                 200                 205            
 Val Arg His Ser Lys Lys His Phe Asp Cys Arg Ala Glu Gly Thr Pro
     210                 215                 220                
 Ser Pro Glu Val Met Trp Ile Met Pro Asp Asn Ile Phe Leu Thr Ala
 225                 230                 235                 240
 Pro Tyr Tyr Gly Ser Arg Ile Thr Val His Lys Asn Gly Thr Leu Glu
                 245                 250                 255    
 Ile Arg Asn Val Arg Leu Ser Asp Ser Ala Asp Phe Ile Cys Val Ala
             260                 265                 270        
 Arg Asn Glu Gly Gly Glu Ser Val Leu Val Val Gln Leu Glu Val Leu
         275                 280                 285            
 Glu Met Leu Arg Arg Pro Thr Phe Arg Asn Pro Phe Asn Glu Lys Ile
     290                 295                 300                
 Val Ala Gln Leu Gly Lys Ser Thr Ala Leu Asn Cys Ser Val Asp Gly
 305                 310                 315                 320
 Asn Pro Pro Pro Glu Ile Ile Trp Ile Leu Pro Asn Gly Thr Arg Phe
                 325                 330                 335    
 Ser Asn Gly Pro Gln Ser Tyr Gln Tyr Leu Ile Ala Ser Asn Gly Ser
             340                 345                 350        
 Phe Ile Ile Ser Lys Thr Thr Arg Glu Asp Ala Gly Lys Tyr Arg Cys
         355                 360                 365            
 Ala Ala Arg Asn Lys Val Gly Tyr Ile Glu Lys Leu Val Ile Leu Glu
     370                 375                 380                
 Ile Gly Gln Lys Pro Val Ile Leu Thr Tyr Ala Pro Gly Thr Val Lys
 385                 390                 395                 400
 Gly Ile Ser Gly Glu Ser Leu Ser Leu His Cys Val Ser Asp Gly Ile
                 405                 410                 415    
 Pro Lys Pro Asn Ile Lys Trp Thr Met Pro Ser Gly Tyr Val Val Asp
             420                 425                 430        
 Arg Pro Gln Ile Asn Gly Lys Tyr Ile Leu His Asp Asn Gly Thr Leu
         435                 440                 445            
 Val Ile Lys Glu Ala Thr Ala Tyr Asp Arg Gly Asn Tyr Ile Cys Lys
     450                 455                 460                
 Ala Gln Asn Ser Val Gly His Thr Leu Ile Thr Val Pro Val Met Ile
 465                 470                 475                 480
 Val Ala Tyr Pro Pro Arg Ile Thr Asn Arg Pro Pro Arg Ser Ile Val
                 485                 490                 495    
 Thr Arg Thr Gly Ala Ala Phe Gln Leu His Cys Val Ala Leu Gly Val
             500                 505                 510        
 Pro Lys Pro Glu Ile Thr Trp Glu Met Pro Asp His Ser Leu Leu Ser
         515                 520                 525            
 Thr Ala Ser Lys Glu Arg Thr His Gly Ser Glu Gln Leu His Leu Gln
     530                 535                 540                
 Gly Thr Leu Val Ile Gln Asn Pro Gln Thr Ser Asp Ser Gly Ile Tyr
 545                 550                 555                 560
 Lys Cys Thr Ala Lys Asn Pro Leu Gly Ser Asp Tyr Ala Ala Thr Tyr
                 565                 570                 575    
 Ile Gln Val Ile
             580



      <210> 2084
      <211> 580
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(580)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2084
 Val Ser Ala Val Glu Phe Val Leu His Gly Lys Asp Phe Gln Val Asp
   1               5                  10                  15    
 Cys Lys Ala Ser Gly Ser Pro Val Pro Xaa Ile Ser Trp Ser Leu Leu
              20                  25                  30        
 Asp Gly Thr Met Ile Asn Asn Ala Met Gln Ala Asp Asp Ser Gly His
          35                  40                  45            
 Arg Thr Arg Arg Tyr Thr Leu Phe Asn Asn Gly Thr Leu Tyr Phe Asn
      50                  55                  60                
 Lys Val Gly Val Ala Glu Glu Gly Asp Tyr Thr Cys Tyr Ala Gln Asn
  65                  70                  75                  80
 Thr Leu Gly Lys Asp Glu Met Lys Val His Leu Thr Val Ile Thr Ala
                  85                  90                  95    
 Ala Pro Arg Ile Arg Gln Ser Asn Lys Thr Asn Lys Arg Ile Lys Ala
             100                 105                 110        
 Gly Asp Thr Ala Val Leu Asp Cys Glu Val Thr Gly Asp Pro Lys Pro
         115                 120                 125            
 Lys Ile Phe Trp Leu Leu Pro Ser Asn Asp Met Ile Ser Phe Ser Ile
     130                 135                 140                
 Asp Arg Tyr Thr Phe His Ala Asn Gly Ser Leu Thr Ile Asn Lys Val
 145                 150                 155                 160
 Lys Leu Leu Asp Ser Gly Glu Tyr Val Cys Val Ala Arg Asn Pro Ser
                 165                 170                 175    
 Gly Asp Asp Thr Lys Met Tyr Lys Leu Asp Val Val Ser Lys Pro Pro
             180                 185                 190        
 Leu Ile Asn Gly Leu Tyr Thr Asn Arg Thr Val Ile Lys Ala Thr Ala
         195                 200                 205            
 Val Arg His Ser Lys Lys His Phe Asp Cys Arg Ala Glu Gly Thr Pro
     210                 215                 220                
 Ser Pro Glu Val Met Trp Ile Met Pro Asp Asn Ile Phe Leu Thr Ala
 225                 230                 235                 240
 Pro Tyr Tyr Gly Ser Arg Ile Thr Val His Lys Asn Gly Thr Leu Glu
                 245                 250                 255    
 Ile Arg Asn Val Arg Leu Ser Asp Ser Ala Asp Phe Ile Cys Val Ala
             260                 265                 270        
 Arg Asn Glu Gly Gly Glu Ser Val Leu Val Val Gln Leu Glu Val Leu
         275                 280                 285            
 Glu Met Leu Arg Arg Pro Thr Phe Arg Asn Pro Phe Asn Glu Lys Ile
     290                 295                 300                
 Val Ala Gln Leu Gly Lys Ser Thr Ala Leu Asn Cys Ser Val Asp Gly
 305                 310                 315                 320
 Asn Pro Pro Pro Glu Ile Ile Trp Ile Leu Pro Asn Gly Thr Arg Phe
                 325                 330                 335    
 Ser Asn Gly Pro Gln Ser Tyr Gln Tyr Leu Ile Ala Ser Asn Gly Ser
             340                 345                 350        
 Phe Ile Ile Ser Lys Thr Thr Arg Glu Asp Ala Gly Lys Tyr Arg Cys
         355                 360                 365            
 Ala Ala Arg Asn Lys Val Gly Tyr Ile Glu Lys Leu Val Ile Leu Glu
     370                 375                 380                
 Ile Gly Gln Lys Pro Val Ile Leu Thr Tyr Ala Pro Gly Thr Val Lys
 385                 390                 395                 400
 Gly Ile Ser Gly Glu Ser Leu Ser Leu His Cys Val Ser Asp Gly Ile
                 405                 410                 415    
 Pro Lys Pro Asn Ile Lys Trp Thr Met Pro Ser Gly Tyr Val Val Asp
             420                 425                 430        
 Arg Pro Gln Ile Asn Gly Lys Tyr Ile Leu His Asp Asn Gly Thr Leu
         435                 440                 445            
 Val Ile Lys Glu Ala Thr Ala Tyr Asp Arg Gly Asn Tyr Ile Cys Lys
     450                 455                 460                
 Ala Gln Asn Ser Val Gly His Thr Leu Ile Thr Val Pro Val Met Ile
 465                 470                 475                 480
 Val Ala Tyr Pro Pro Arg Ile Thr Asn Arg Pro Pro Arg Ser Ile Val
                 485                 490                 495    
 Thr Arg Thr Gly Ala Ala Phe Gln Leu His Cys Val Ala Leu Gly Val
             500                 505                 510        
 Pro Lys Pro Glu Ile Thr Trp Glu Met Pro Asp His Ser Leu Leu Ser
         515                 520                 525            
 Thr Ala Ser Lys Glu Arg Thr His Gly Ser Glu Gln Leu His Leu Gln
     530                 535                 540                
 Gly Thr Leu Val Ile Gln Asn Pro Gln Thr Ser Asp Ser Gly Ile Tyr
 545                 550                 555                 560
 Lys Cys Thr Ala Lys Asn Pro Leu Gly Ser Asp Tyr Ala Ala Thr Tyr
                 565                 570                 575    
 Ile Gln Val Ile
             580



      <210> 2085
      <211> 580
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(580)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2085
 Val Ser Ala Val Glu Phe Val Leu His Gly Lys Asp Phe Gln Val Asp
   1               5                  10                  15    
 Cys Lys Ala Ser Gly Ser Pro Val Pro Xaa Ile Ser Trp Ser Leu Leu
              20                  25                  30        
 Asp Gly Thr Met Ile Asn Asn Ala Met Gln Ala Asp Asp Ser Gly His
          35                  40                  45            
 Arg Thr Arg Arg Tyr Thr Leu Phe Asn Asn Gly Thr Leu Tyr Phe Asn
      50                  55                  60                
 Lys Val Gly Val Ala Glu Glu Gly Asp Tyr Thr Cys Tyr Ala Gln Asn
  65                  70                  75                  80
 Thr Leu Gly Lys Asp Glu Met Lys Val His Leu Thr Val Ile Thr Ala
                  85                  90                  95    
 Ala Pro Arg Ile Arg Gln Ser Asn Lys Thr Asn Lys Arg Ile Lys Ala
             100                 105                 110        
 Gly Asp Thr Ala Val Leu Asp Cys Glu Val Thr Gly Asp Pro Lys Pro
         115                 120                 125            
 Lys Ile Phe Trp Leu Leu Pro Ser Asn Asp Met Ile Ser Phe Ser Ile
     130                 135                 140                
 Asp Arg Tyr Thr Phe His Ala Asn Gly Ser Leu Thr Ile Asn Lys Val
 145                 150                 155                 160
 Lys Leu Leu Asp Ser Gly Glu Tyr Val Cys Val Ala Arg Asn Pro Ser
                 165                 170                 175    
 Gly Asp Asp Thr Lys Met Tyr Lys Leu Asp Val Val Ser Lys Pro Pro
             180                 185                 190        
 Leu Ile Asn Gly Leu Tyr Thr Asn Arg Thr Val Ile Lys Ala Thr Ala
         195                 200                 205            
 Val Arg His Ser Lys Lys His Phe Asp Cys Arg Ala Glu Gly Thr Pro
     210                 215                 220                
 Ser Pro Glu Val Met Trp Ile Met Pro Asp Asn Ile Phe Leu Thr Ala
 225                 230                 235                 240
 Pro Tyr Tyr Gly Ser Arg Ile Thr Val His Lys Asn Gly Thr Leu Glu
                 245                 250                 255    
 Ile Arg Asn Val Arg Leu Ser Asp Ser Ala Asp Phe Ile Cys Val Ala
             260                 265                 270        
 Arg Asn Glu Gly Gly Glu Ser Val Leu Val Val Gln Leu Glu Val Leu
         275                 280                 285            
 Glu Met Leu Arg Arg Pro Thr Phe Arg Asn Pro Phe Asn Glu Lys Ile
     290                 295                 300                
 Val Ala Gln Leu Gly Lys Ser Thr Ala Leu Asn Cys Ser Val Asp Gly
 305                 310                 315                 320
 Asn Pro Pro Pro Glu Ile Ile Trp Ile Leu Pro Asn Gly Thr Arg Phe
                 325                 330                 335    
 Ser Asn Gly Pro Gln Ser Tyr Gln Tyr Leu Ile Ala Ser Asn Gly Ser
             340                 345                 350        
 Phe Ile Ile Ser Lys Thr Thr Arg Glu Asp Ala Gly Lys Tyr Arg Cys
         355                 360                 365            
 Ala Ala Arg Asn Lys Val Gly Tyr Ile Glu Lys Leu Val Ile Leu Glu
     370                 375                 380                
 Ile Gly Gln Lys Pro Val Ile Leu Thr Tyr Ala Pro Gly Thr Val Lys
 385                 390                 395                 400
 Gly Ile Ser Gly Glu Ser Leu Ser Leu His Cys Val Ser Asp Gly Ile
                 405                 410                 415    
 Pro Lys Pro Asn Ile Lys Trp Thr Met Pro Ser Gly Tyr Val Val Asp
             420                 425                 430        
 Arg Pro Gln Ile Asn Gly Lys Tyr Ile Leu His Asp Asn Gly Thr Leu
         435                 440                 445            
 Val Ile Lys Glu Ala Thr Ala Tyr Asp Arg Gly Asn Tyr Ile Cys Lys
     450                 455                 460                
 Ala Gln Asn Ser Val Gly His Thr Leu Ile Thr Val Pro Val Met Ile
 465                 470                 475                 480
 Val Ala Tyr Pro Pro Arg Ile Thr Asn Arg Pro Pro Arg Ser Ile Val
                 485                 490                 495    
 Thr Arg Thr Gly Ala Ala Phe Gln Leu His Cys Val Ala Leu Gly Val
             500                 505                 510        
 Pro Lys Pro Glu Ile Thr Trp Glu Met Pro Asp His Ser Leu Leu Ser
         515                 520                 525            
 Thr Ala Ser Lys Glu Arg Thr His Gly Ser Glu Gln Leu His Leu Gln
     530                 535                 540                
 Gly Thr Leu Val Ile Gln Asn Pro Gln Thr Ser Asp Ser Gly Ile Tyr
 545                 550                 555                 560
 Lys Cys Thr Ala Lys Asn Pro Leu Gly Ser Asp Tyr Ala Ala Thr Tyr
                 565                 570                 575    
 Ile Gln Val Ile
             580



      <210> 2086
      <211> 32
      <212> PRT
      <213> Homo sapiens


      <400> 2086
 Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln
   1               5                  10                  15    
 Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Ser Glu Asn Asn Val Leu
              20                  25                  30        





      <210> 2087
      <211> 366
      <212> PRT
      <213> Homo sapiens


      <400> 2087
 Met Ala Ser Met Ala Ala Val Leu Thr Trp Ala Leu Ala Leu Leu Ser
   1               5                  10                  15    
 Ala Phe Ser Ala Thr Gln Ala Arg Lys Gly Phe Trp Asp Tyr Phe Ser
              20                  25                  30        
 Gln Thr Ser Gly Asp Lys Gly Arg Val Glu Gln Ile His Gln Gln Lys
          35                  40                  45            
 Met Ala Arg Glu Pro Ala Thr Leu Lys Asp Ser Leu Glu Gln Asp Leu
      50                  55                  60                
 Asn Asn Met Asn Lys Phe Leu Glu Lys Leu Arg Pro Leu Ser Gly Ser
  65                  70                  75                  80
 Glu Ala Pro Arg Leu Pro Gln Asp Pro Val Gly Met Arg Arg Gln Leu
                  85                  90                  95    
 Gln Glu Glu Leu Glu Glu Val Lys Ala Arg Leu Gln Pro Tyr Met Ala
             100                 105                 110        
 Glu Ala His Glu Leu Val Gly Trp Asn Leu Glu Gly Leu Arg Gln Gln
         115                 120                 125            
 Leu Lys Pro Tyr Thr Met Asp Leu Met Glu Gln Val Ala Leu Arg Val
     130                 135                 140                
 Gln Glu Leu Gln Glu Gln Leu Arg Val Val Gly Glu Asp Thr Lys Ala
 145                 150                 155                 160
 Gln Leu Leu Gly Gly Val Asp Glu Ala Trp Ala Leu Leu Gln Gly Leu
                 165                 170                 175    
 Gln Ser Arg Val Val His His Thr Gly Arg Phe Lys Glu Leu Phe His
             180                 185                 190        
 Pro Tyr Ala Glu Ser Leu Val Ser Gly Ile Gly Arg His Val Gln Glu
         195                 200                 205            
 Leu His Arg Ser Val Ala Pro His Ala Pro Ala Ser Pro Ala Arg Leu
     210                 215                 220                
 Ser Arg Cys Val Gln Val Leu Ser Arg Lys Leu Thr Leu Lys Ala Lys
 225                 230                 235                 240
 Ala Leu His Ala Arg Ile Gln Gln Asn Leu Asp Gln Leu Arg Glu Glu
                 245                 250                 255    
 Leu Ser Arg Ala Phe Ala Gly Thr Gly Thr Glu Glu Gly Ala Gly Pro
             260                 265                 270        
 Asp Pro Gln Met Leu Ser Glu Glu Val Arg Gln Arg Leu Gln Ala Phe
         275                 280                 285            
 Arg Gln Asp Thr Tyr Leu Gln Ile Ala Ala Phe Thr Arg Ala Ile Asp
     290                 295                 300                
 Gln Glu Thr Glu Glu Val Gln Gln Gln Leu Ala Pro Pro Pro Pro Gly
 305                 310                 315                 320
 His Ser Ala Phe Ala Pro Glu Phe Gln Gln Thr Asp Ser Gly Lys Val
                 325                 330                 335    
 Leu Ser Lys Leu Gln Ala Arg Leu Asp Asp Leu Trp Glu Asp Ile Thr
             340                 345                 350        
 His Ser Leu His Asp Gln Gly His Ser His Leu Gly Asp Pro
         355                 360                 365    



      <210> 2088
      <211> 366
      <212> PRT
      <213> Homo sapiens


      <400> 2088
 Met Ala Ser Met Ala Ala Val Leu Thr Trp Ala Leu Ala Leu Leu Ser
   1               5                  10                  15    
 Ala Phe Ser Ala Thr Gln Ala Arg Lys Gly Phe Trp Asp Tyr Phe Ser
              20                  25                  30        
 Gln Thr Ser Gly Asp Lys Gly Arg Val Glu Gln Ile His Gln Gln Lys
          35                  40                  45            
 Met Ala Arg Glu Pro Ala Thr Leu Lys Asp Ser Leu Glu Gln Asp Leu
      50                  55                  60                
 Asn Asn Met Asn Lys Phe Leu Glu Lys Leu Arg Pro Leu Ser Gly Ser
  65                  70                  75                  80
 Glu Ala Pro Arg Leu Pro Gln Asp Pro Val Gly Met Arg Arg Gln Leu
                  85                  90                  95    
 Gln Glu Glu Leu Glu Glu Val Lys Ala Arg Leu Gln Pro Tyr Met Ala
             100                 105                 110        
 Glu Ala His Glu Leu Val Gly Trp Asn Leu Glu Gly Leu Arg Gln Gln
         115                 120                 125            
 Leu Lys Pro Tyr Thr Met Asp Leu Met Glu Gln Val Ala Leu Arg Val
     130                 135                 140                
 Gln Glu Leu Gln Glu Gln Leu Arg Val Val Gly Glu Asp Thr Lys Ala
 145                 150                 155                 160
 Gln Leu Leu Gly Gly Val Asp Glu Ala Trp Ala Leu Leu Gln Gly Leu
                 165                 170                 175    
 Gln Ser Arg Val Val His His Thr Gly Arg Phe Lys Glu Leu Phe His
             180                 185                 190        
 Pro Tyr Ala Glu Ser Leu Val Ser Gly Ile Gly Arg His Val Gln Glu
         195                 200                 205            
 Leu His Arg Ser Val Ala Pro His Ala Pro Ala Ser Pro Ala Arg Leu
     210                 215                 220                
 Ser Arg Cys Val Gln Val Leu Ser Arg Lys Leu Thr Leu Lys Ala Lys
 225                 230                 235                 240
 Ala Leu His Ala Arg Ile Gln Gln Asn Leu Asp Gln Leu Arg Glu Glu
                 245                 250                 255    
 Leu Ser Arg Ala Phe Ala Gly Thr Gly Thr Glu Glu Gly Ala Gly Pro
             260                 265                 270        
 Asp Pro Gln Met Leu Ser Glu Glu Val Arg Gln Arg Leu Gln Ala Phe
         275                 280                 285            
 Arg Gln Asp Thr Tyr Leu Gln Ile Ala Ala Phe Thr Arg Ala Ile Asp
     290                 295                 300                
 Gln Glu Thr Glu Glu Val Gln Gln Gln Leu Ala Pro Pro Pro Pro Gly
 305                 310                 315                 320
 His Ser Ala Phe Ala Pro Glu Phe Gln Gln Thr Asp Ser Gly Lys Val
                 325                 330                 335    
 Leu Ser Lys Leu Gln Ala Arg Leu Asp Asp Leu Trp Glu Asp Ile Thr
             340                 345                 350        
 His Ser Leu His Asp Gln Gly His Ser His Leu Gly Asp Pro
         355                 360                 365    



      <210> 2089
      <211> 290
      <212> PRT
      <213> Homo sapiens


      <400> 2089
 Asp Phe Gly Glu Phe Met Arg Glu Asn Arg Leu Thr Pro Phe Leu Asp
   1               5                  10                  15    
 Pro Arg Tyr Lys Ile Asp Gly Ser Leu Glu Val Pro Leu Glu Arg Ala
              20                  25                  30        
 Lys Asp Gln Leu Glu Lys His Thr Arg Tyr Trp Pro Met Ile Ile Ser
          35                  40                  45            
 Gln Thr Thr Ile Phe Asn Met Gln Ala Val Val Pro Leu Ala Ser Val
      50                  55                  60                
 Ile Val Lys Glu Ser Leu Thr Glu Glu Asp Val Leu Asn Cys Gln Lys
  65                  70                  75                  80
 Thr Ile Tyr Asn Leu Val Asp Met Glu Arg Lys Asn Asp Pro Leu Pro
                  85                  90                  95    
 Ile Ser Thr Val Gly Thr Arg Gly Lys Gly Pro Lys Arg Asp Glu Gln
             100                 105                 110        
 Tyr Arg Ile Met Trp Asn Glu Leu Glu Thr Leu Val Arg Ala His Ile
         115                 120                 125            
 Asn Asn Ser Glu Lys His Gln Arg Val Leu Glu Cys Leu Met Ala Cys
     130                 135                 140                
 Arg Ser Lys Pro Pro Glu Glu Glu Glu Arg Lys Lys Arg Gly Arg Lys
 145                 150                 155                 160
 Arg Glu Asp Lys Glu Asp Lys Ser Glu Lys Ala Val Lys Asp Tyr Glu
                 165                 170                 175    
 Gln Glu Lys Ser Trp Gln Asp Ser Glu Arg Leu Lys Gly Ile Leu Glu
             180                 185                 190        
 Arg Gly Lys Glu Glu Leu Ala Glu Ala Glu Ile Ile Lys Asp Ser Pro
         195                 200                 205            
 Asp Ser Pro Glu Pro Pro Asn Lys Lys Pro Leu Val Glu Met Asp Glu
     210                 215                 220                
 Thr Pro Gln Val Glu Lys Ser Lys Gly Pro Val Ser Leu Leu Ser Leu
 225                 230                 235                 240
 Trp Ser Asn Arg Ile Asn Thr Ala Asn Ser Arg Lys His Gln Glu Phe
                 245                 250                 255    
 Ala Gly Arg Leu Asn Ser Val Asn Asn Arg Ala Glu Leu Tyr Gln His
             260                 265                 270        
 Leu Lys Glu Glu Asn Gly Met Glu Thr Thr Glu Asn Gly Lys Ala Ser
         275                 280                 285            
 Arg Gln
     290



      <210> 2090
      <211> 150
      <212> PRT
      <213> Homo sapiens


      <400> 2090
 Arg Trp Asn Ser Ile Met Glu Leu Ala Leu Leu Cys Gly Leu Val Val
   1               5                  10                  15    
 Met Ala Gly Val Ile Pro Ile Gln Gly Gly Ile Leu Asn Leu Asn Lys
              20                  25                  30        
 Met Val Lys Gln Val Thr Gly Lys Met Pro Ile Leu Ser Tyr Trp Pro
          35                  40                  45            
 Tyr Gly Cys His Cys Gly Leu Gly Gly Arg Gly Gln Pro Lys Asp Ala
      50                  55                  60                
 Thr Asp Trp Cys Cys Gln Thr His Asp Cys Cys Tyr Asp His Leu Lys
  65                  70                  75                  80
 Thr Gln Gly Cys Gly Ile Tyr Lys Asp Tyr Tyr Arg Tyr Asn Phe Ser
                  85                  90                  95    
 Gln Gly Asn Ile His Cys Ser Asp Lys Gly Ser Trp Cys Glu Gln Gln
             100                 105                 110        
 Leu Cys Ala Cys Asp Lys Glu Val Ala Phe Cys Leu Lys Arg Asn Leu
         115                 120                 125            
 Asp Thr Tyr Gln Lys Arg Leu Arg Phe Tyr Trp Arg Pro His Cys Arg
     130                 135                 140                
 Gly Gln Thr Pro Gly Cys
 145                 150



      <210> 2091
      <211> 154
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(154)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2091
 Glu Gly Glu Glu Pro Arg Asp Xaa Pro Lys Met Pro Leu Thr Pro Glu
   1               5                  10                  15    
 Pro Pro Val Trp Ala Arg Gly Gly Ala Pro Arg Met Gly Ser Ser Pro
              20                  25                  30        
 Met Ala Leu Thr Ala Leu Trp Ala Leu His Pro His His Ala Gly Pro
          35                  40                  45            
 Gly His Pro Gly Cys Ala Leu His Pro His His Arg Cys Val Gly Xaa
      50                  55                  60                
 Thr Pro Val Pro Pro Cys Ser Pro Pro Arg Pro Gln Pro Pro Cys Thr
  65                  70                  75                  80
 His Pro Gly Val Ala Pro Arg Arg Arg Ala Val Asp Xaa Ala His Gly
                  85                  90                  95    
 His Arg Pro Arg Ala Leu Xaa Gly Leu Val Trp Leu Cys Gly Pro Pro
             100                 105                 110        
 Ala Asp Arg Ser Gly Pro Xaa Ala Ser His Pro Ala Thr Trp Ala Pro
         115                 120                 125            
 Arg Pro Tyr Trp Arg Ser Gln Pro Gly Ala Pro Ser Gly Gly Pro Ser
     130                 135                 140                
 Pro Gly Arg Gly Gly Pro Pro Pro Gln Ala
 145                 150                



      <210> 2092
      <211> 467
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(467)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2092
 Val Ile Pro Pro Val Leu Thr Ala Arg Gly Pro Arg Pro Arg Gly Ala
   1               5                  10                  15    
 Gly Ala Met Val Arg Gly Arg Ile Ser Arg Leu Ser Val Arg Asp Val
              20                  25                  30        
 Arg Phe Pro Thr Ser Leu Gly Gly His Gly Ala Asp Ala Met His Thr
          35                  40                  45            
 Asp Pro Asp Tyr Ser Ala Ala Tyr Val Val Ile Glu Thr Asp Ala Glu
      50                  55                  60                
 Asp Gly Ile Lys Gly Cys Gly Ile Thr Phe Thr Leu Gly Lys Gly Thr
  65                  70                  75                  80
 Glu Val Val Val Cys Ala Val Asn Ala Leu Ala His His Val Leu Asn
                  85                  90                  95    
 Lys Asp Leu Lys Asp Ile Val Gly Asp Phe Arg Gly Phe Tyr Arg Gln
             100                 105                 110        
 Leu Thr Ser Asp Gly Gln Leu Arg Trp Ile Gly Pro Glu Lys Gly Val
         115                 120                 125            
 Val His Leu Ala Thr Ala Ala Val Leu Asn Ala Val Trp Asp Leu Trp
     130                 135                 140                
 Ala Lys Gln Glu Gly Lys Pro Val Trp Lys Leu Leu Val Asp Met Asp
 145                 150                 155                 160
 Pro Arg Met Leu Val Ser Cys Ile Asp Phe Arg Tyr Ile Thr Asp Val
                 165                 170                 175    
 Leu Thr Glu Glu Asp Ala Leu Glu Ile Leu Gln Lys Gly Gln Ile Gly
             180                 185                 190        
 Lys Lys Glu Arg Glu Lys Gln Met Leu Ala Gln Gly Tyr Pro Ala Tyr
         195                 200                 205            
 Thr Thr Ser Cys Ala Trp Leu Gly Tyr Ser Asp Asp Thr Leu Lys Gln
     210                 215                 220                
 Leu Cys Ala Gln Ala Leu Lys Asp Gly Trp Thr Arg Phe Lys Val Lys
 225                 230                 235                 240
 Val Gly Ala Asp Leu Gln Asp Asp Met Arg Arg Cys Gln Ile Ile Arg
                 245                 250                 255    
 Asp Met Ile Gly Pro Glu Lys Thr Leu Met Met Asp Ala Asn Gln Arg
             260                 265                 270        
 Trp Asp Val Pro Glu Ala Val Glu Trp Met Ser Lys Leu Ala Lys Phe
         275                 280                 285            
 Lys Pro Leu Trp Ile Glu Glu Pro Thr Ser Pro Xaa Leu Thr Phe Leu
     290                 295                 300                
 Gly His Ala Thr Ile Ser Lys Ala Leu Val Pro Phe Arg Glu Leu Gly
 305                 310                 315                 320
 Ile Cys Thr Arg Glu Asn Ser Cys His Asn Arg Val Ile Phe Lys Gln
                 325                 330                 335    
 Leu Leu Gln Ala Lys Ala Leu Gln Phe Leu Gln Ile Asp Ser Cys Arg
             340                 345                 350        
 Leu Gly Ser Val Asn Glu Asn Leu Ser Val Leu Leu Met Ala Lys Lys
         355                 360                 365            
 Phe Glu Ile Pro Val Cys Pro His Ala Gly Gly Val Gly Leu Cys Glu
     370                 375                 380                
 Leu Val Gln His Leu Ile Ile Phe Asp Tyr Ile Ser Val Ser Ala Ser
 385                 390                 395                 400
 Leu Glu Asn Arg Val Cys Glu Tyr Val Asp His Leu His Glu His Phe
                 405                 410                 415    
 Lys Tyr Pro Val Met Ile Gln Arg Ala Ser Tyr Met Pro Pro Lys Asp
             420                 425                 430        
 Pro Gly Tyr Ser Thr Glu Leu Lys Glu Glu Ser Cys Lys Arg Asn Thr
         435                 440                 445            
 Gln Tyr Pro Gln Met Gly Glu Val Trp Glu Glu Thr Pro Phe Pro Ala
     450                 455                 460                
 Gln Glu Asn
 465        



      <210> 2093
      <211> 43
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(43)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2093
 Ser Gly Arg Leu Ala Pro His Thr Ser Arg Arg Thr Ser Ala Asn Cys
   1               5                  10                  15    
 Ser Asp Asp Ala Lys Ser Ser Asp Ser Cys Ser Pro Ser Arg Lys Thr
              20                  25                  30        
 Xaa Trp Ser Gly Arg Asn Thr Asn Arg Ile His
          35                  40            



      <210> 2094
      <211> 421
      <212> PRT
      <213> Homo sapiens


      <400> 2094
 Ile Pro Gly Ser Thr Ile Ser Trp Ser Pro Ala Ala Ala Arg Gly Leu
   1               5                  10                  15    
 Ser Val Cys Arg Cys Cys Arg Leu His Pro Ala Ser Ala Met Asp Leu
              20                  25                  30        
 Phe Gly Asp Leu Pro Glu Pro Glu Arg Ser Pro Arg Pro Ala Ala Gly
          35                  40                  45            
 Lys Glu Ala Gln Lys Gly Pro Leu Leu Phe Asp Asp Leu Pro Pro Ala
      50                  55                  60                
 Ser Ser Thr Asp Ser Gly Ser Gly Gly Pro Leu Leu Phe Asp Asp Leu
  65                  70                  75                  80
 Pro Pro Ala Ser Ser Gly Asp Ser Gly Ser Leu Ala Thr Ser Ile Ser
                  85                  90                  95    
 Gln Met Val Lys Thr Glu Gly Lys Gly Ala Lys Arg Lys Thr Ser Glu
             100                 105                 110        
 Glu Glu Lys Asn Gly Ser Glu Glu Leu Val Glu Lys Lys Val Cys Lys
         115                 120                 125            
 Ala Ser Ser Val Ile Phe Gly Leu Lys Gly Tyr Val Ala Glu Arg Lys
     130                 135                 140                
 Gly Glu Arg Glu Glu Met Gln Asp Ala His Val Ile Leu Asn Asp Ile
 145                 150                 155                 160
 Thr Glu Glu Cys Arg Pro Pro Ser Ser Leu Ile Thr Arg Val Ser Tyr
                 165                 170                 175    
 Phe Ala Val Phe Asp Gly His Gly Gly Ile Arg Ala Ser Lys Phe Ala
             180                 185                 190        
 Ala Gln Asn Leu His Gln Asn Leu Ile Arg Lys Phe Pro Lys Gly Asp
         195                 200                 205            
 Val Ile Ser Val Glu Lys Thr Val Lys Arg Cys Leu Leu Asp Thr Phe
     210                 215                 220                
 Lys His Thr Asp Glu Glu Phe Leu Lys Gln Ala Ser Ser Gln Lys Pro
 225                 230                 235                 240
 Ala Trp Lys Asp Gly Ser Thr Ala Thr Cys Val Leu Ala Val Asp Asn
                 245                 250                 255    
 Ile Leu Tyr Ile Ala Asn Leu Gly Asp Ser Arg Ala Ile Leu Cys Arg
             260                 265                 270        
 Tyr Asn Glu Glu Ser Gln Lys His Ala Ala Leu Ser Leu Ser Lys Glu
         275                 280                 285            
 His Asn Pro Thr Gln Tyr Glu Glu Arg Met Arg Ile Gln Lys Ala Gly
     290                 295                 300                
 Gly Asn Val Arg Asp Gly Arg Val Leu Gly Val Leu Glu Val Ser Arg
 305                 310                 315                 320
 Ser Ile Gly Asp Gly Gln Tyr Lys Arg Cys Gly Val Thr Ser Val Pro
                 325                 330                 335    
 Asp Ile Arg Arg Cys Gln Leu Thr Pro Asn Asp Arg Phe Ile Leu Leu
             340                 345                 350        
 Ala Cys Asp Gly Leu Phe Lys Val Phe Thr Pro Glu Glu Ala Val Asn
         355                 360                 365            
 Phe Ile Leu Ser Cys Leu Glu Asp Glu Lys Ile Gln Thr Arg Glu Gly
     370                 375                 380                
 Lys Ser Ala Ala Asp Ala Arg Tyr Glu Ala Ala Cys Asn Arg Leu Ala
 385                 390                 395                 400
 Asn Lys Ala Val Gln Arg Gly Ser Ala Asp Asn Val Thr Val Met Val
                 405                 410                 415    
 Val Arg Ile Gly His
             420    



      <210> 2095
      <211> 181
      <212> PRT
      <213> Homo sapiens


      <400> 2095
 Phe Val Gly His Cys Val Asn Thr Glu Gly Gly Phe Val Cys Glu Arg
   1               5                  10                  15    
 Gly Pro Gly Met Arg Val Ser Ala Asp Arg His Ser Cys Gln Asp Thr
              20                  25                  30        
 Asp Glu Cys Leu Gly Thr Pro Cys Gln Gln Arg Cys Lys Asn Ser Ile
          35                  40                  45            
 Gly Ser Tyr Lys Cys Ser Cys Arg Thr Gly Phe His Leu His Gly Asn
      50                  55                  60                
 Arg His Ser Cys Val Asp Tyr Thr Pro Arg Ile Pro Leu Cys Ser Pro
  65                  70                  75                  80
 Ile Phe Leu Ala Ala Phe Ala Pro Leu Asp Val Asn Glu Cys Arg Arg
                  85                  90                  95    
 Pro Leu Glu Arg Arg Val Cys His His Ser Cys His Asn Thr Gly Gly
             100                 105                 110        
 Ser Phe Leu Cys Thr Cys Arg Pro Gly Phe Arg Leu Arg Ala Asp Arg
         115                 120                 125            
 Val Ser Cys Glu Asp Phe Pro Glu Ser Arg Ala Gly Pro Ile Cys His
     130                 135                 140                
 Pro Ala Thr Pro Val Thr Pro Val Gln Glu Cys Tyr Cys Cys Leu Leu
 145                 150                 155                 160
 Arg Pro His Gly Leu Pro Cys Ala Gln Asp Ile Asp Leu Leu Leu Gly
                 165                 170                 175    
 Leu Gln Gly His Gln
             180    



      <210> 2096
      <211> 353
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(353)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2096
 Arg His Leu Leu Thr Ile Phe His Lys Leu Lys Ile Tyr Lys Thr Ile
   1               5                  10                  15    
 Asn Lys Ile Asp Phe Lys Lys Lys Arg Val Thr Gln Leu Leu Val Phe
              20                  25                  30        
 Cys Leu Phe Leu Cys Leu Phe Phe Ser Ser Glu Met Val Lys Asn Gln
          35                  40                  45            
 Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe Leu Leu Gly Pro Arg
      50                  55                  60                
 Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu Phe Tyr Val Phe Thr
  65                  70                  75                  80
 Leu Leu Gly Asn Gly Thr Ile Leu Gly Leu Ile Ser Leu Asp Ser Arg
                  85                  90                  95    
 Leu His Thr Pro Met Tyr Phe Phe Leu Ser His Leu Ala Val Val Asn
             100                 105                 110        
 Ile Ala Tyr Ala Cys Asn Thr Val Pro Gln Met Leu Val Asn Leu Leu
         115                 120                 125            
 His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys Met Thr Xaa Thr Phe
     130                 135                 140                
 Leu Phe Leu Ser Phe Ala His Thr Glu Cys Leu Leu Leu Val Leu Met
 145                 150                 155                 160
 Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Phe Ile
                 165                 170                 175    
 Ile Met Thr Trp Lys Val Cys Ile Thr Leu Ala Ile Thr Ser Trp Thr
             180                 185                 190        
 Cys Gly Ser Leu Leu Ala Met Val His Val Ser Leu Ile Leu Arg Leu
         195                 200                 205            
 Pro Phe Cys Gly Pro Arg Glu Ile Asn His Phe Phe Cys Glu Ile Leu
     210                 215                 220                
 Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp Leu Asn Gln Val Val
 225                 230                 235                 240
 Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly Pro Leu Cys Leu Val
                 245                 250                 255    
 Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile Leu Arg Ile Gln Ser
             260                 265                 270        
 Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser His Leu Cys
         275                 280                 285            
 Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val Met Tyr Met Ala Pro
     290                 295                 300                
 Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val Leu Phe Leu Phe Tyr
 305                 310                 315                 320
 Ser Ser Phe Asn Pro Met Leu Asn Pro Leu Ile Tyr Asn Leu Arg Asn
                 325                 330                 335    
 Val Glu Val Lys Gly Ala Leu Arg Arg Ala Leu Cys Lys Glu Ser His
             340                 345                 350        
 Ser
    



      <210> 2097
      <211> 353
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(353)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2097
 Arg His Leu Leu Thr Ile Phe His Lys Leu Lys Ile Tyr Lys Thr Ile
   1               5                  10                  15    
 Asn Lys Ile Asp Phe Lys Lys Lys Arg Val Thr Gln Leu Leu Val Phe
              20                  25                  30        
 Cys Leu Phe Leu Cys Leu Phe Phe Ser Ser Glu Met Val Lys Asn Gln
          35                  40                  45            
 Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe Leu Leu Gly Pro Arg
      50                  55                  60                
 Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu Phe Tyr Val Phe Thr
  65                  70                  75                  80
 Leu Leu Gly Asn Gly Thr Ile Leu Gly Leu Ile Ser Leu Asp Ser Arg
                  85                  90                  95    
 Leu His Thr Pro Met Tyr Phe Phe Leu Ser His Leu Ala Val Val Asn
             100                 105                 110        
 Ile Ala Tyr Ala Cys Asn Thr Val Pro Gln Met Leu Val Asn Leu Leu
         115                 120                 125            
 His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys Met Thr Xaa Thr Phe
     130                 135                 140                
 Leu Phe Leu Ser Phe Ala His Thr Glu Cys Leu Leu Leu Val Leu Met
 145                 150                 155                 160
 Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Phe Ile
                 165                 170                 175    
 Ile Met Thr Trp Lys Val Cys Ile Thr Leu Ala Ile Thr Ser Trp Thr
             180                 185                 190        
 Cys Gly Ser Leu Leu Ala Met Val His Val Ser Leu Ile Leu Arg Leu
         195                 200                 205            
 Pro Phe Cys Gly Pro Arg Glu Ile Asn His Phe Phe Cys Glu Ile Leu
     210                 215                 220                
 Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp Leu Asn Gln Val Val
 225                 230                 235                 240
 Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly Pro Leu Cys Leu Val
                 245                 250                 255    
 Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile Leu Arg Ile Gln Ser
             260                 265                 270        
 Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser His Leu Cys
         275                 280                 285            
 Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val Met Tyr Met Ala Pro
     290                 295                 300                
 Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val Leu Phe Leu Phe Tyr
 305                 310                 315                 320
 Ser Ser Phe Asn Pro Met Leu Asn Pro Leu Ile Tyr Asn Leu Arg Asn
                 325                 330                 335    
 Val Glu Val Lys Gly Ala Leu Arg Arg Ala Leu Cys Lys Glu Ser His
             340                 345                 350        
 Ser
    



      <210> 2098
      <211> 82
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(82)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2098
 Glu Lys Trp Pro Asp Xaa Ser Arg Ala Ala Cys Pro Val Leu Cys Arg
   1               5                  10                  15    
 Gly Asn Gly Gln Tyr Ser Lys Gly Arg Cys Leu Cys Phe Ser Gly Trp
              20                  25                  30        
 Lys Gly Thr Glu Cys Asp Val Pro Thr Thr Gln Cys Ile Asp Pro Gln
          35                  40                  45            
 Cys Gly Gly Arg Gly Ile Cys Ile Met Gly Ser Cys Ala Cys Asn Ser
      50                  55                  60                
 Gly Tyr Lys Gly Glu Ser Cys Glu Glu Ala Pro Arg Tyr Ile Pro Glu
  65                  70                  75                  80
 Lys Glu
        



      <210> 2099
      <211> 255
      <212> PRT
      <213> Homo sapiens


      <400> 2099
 Arg Glu Thr Gly Ser Val Ser Leu Ser Pro Ser Gly Leu Glu Gly Ala
   1               5                  10                  15    
 Glu Ser Tyr Ala Val Ser Pro Ile Leu Tyr Ser Ser Pro Asp Val Lys
              20                  25                  30        
 Glu Leu Trp Leu Glu Thr Leu Gln Gly Gln Arg His Ser His Thr Gly
          35                  40                  45            
 Val Lys Ser Thr Pro Gly Gln Ser Ala Ala Ile Leu Met Lys Leu Arg
      50                  55                  60                
 Ser Ser His Asn Ala Ser Lys Thr Leu Asn Ala Asn Asn Met Glu Thr
  65                  70                  75                  80
 Leu Ile Glu Cys Gln Ser Glu Gly Asp Ile Lys Glu His Pro Leu Leu
                  85                  90                  95    
 Ala Ser Cys Glu Ser Glu Asp Ser Ile Cys Gln Leu Ile Glu Val Lys
             100                 105                 110        
 Lys Arg Lys Lys Val Leu Ser Trp Pro Phe Leu Met Arg Arg Leu Ser
         115                 120                 125            
 Pro Ala Ser Asp Phe Ser Gly Ala Leu Glu Thr Asp Leu Lys Ala Ser
     130                 135                 140                
 Leu Phe Asp Gln Pro Leu Ser Ile Ile Cys Gly Asp Ser Asp Thr Leu
 145                 150                 155                 160
 Pro Arg Pro Ile Gln Asp Ile Leu Thr Ile Leu Cys Leu Lys Gly Pro
                 165                 170                 175    
 Ser Thr Glu Gly Ile Phe Arg Arg Ala Ala Asn Glu Lys Ala Arg Lys
             180                 185                 190        
 Glu Leu Lys Glu Glu Leu Asn Ser Gly Asp Ala Val Asp Leu Glu Arg
         195                 200                 205            
 Leu Pro Val His Leu Leu Ala Val Val Phe Lys Asp Phe Leu Arg Ser
     210                 215                 220                
 Ile Pro Arg Lys Leu Leu Ser Ser Asp Leu Phe Glu Glu Trp Met Gly
 225                 230                 235                 240
 Ala Leu Glu Met Gln Asp Glu Glu Asp Arg Ile Glu Ala Leu Lys
                 245                 250                 255



      <210> 2100
      <211> 126
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(126)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2100
 Phe Phe Phe Gly Asn Gly Val Ser Pro Cys Arg Gln Ala Gly Val Xaa
   1               5                  10                  15    
 Trp His Asp Leu Asp Ser Leu Gln Asn Leu Pro Pro Gly Phe Lys Arg
              20                  25                  30        
 Phe Ser Tyr Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg His Val Leu
          35                  40                  45            
 Pro Arg Gln Ala Asn Phe Cys Ile Phe Met Xaa Arg Arg Gly Phe Thr
      50                  55                  60                
 Met Leu Ala Arg Met Val Ser Ile Ser Xaa Pro Arg Asp Leu Pro Ala
  65                  70                  75                  80
 Leu Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Ser His His Ala Pro
                  85                  90                  95    
 Pro Gln Met Asp Phe Thr Phe Ala Leu Leu Cys Phe Ala Leu Lys Gly
             100                 105                 110        
 Cys Leu Pro Arg Gln Lys Glu Gly Gly Thr Leu Asn Leu Ile
         115                 120                 125    



      <210> 2101
      <211> 126
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(126)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2101
 Phe Phe Phe Gly Asn Gly Val Ser Pro Cys Arg Gln Ala Gly Val Xaa
   1               5                  10                  15    
 Trp His Asp Leu Asp Ser Leu Gln Asn Leu Pro Pro Gly Phe Lys Arg
              20                  25                  30        
 Phe Ser Tyr Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg His Val Leu
          35                  40                  45            
 Pro Arg Gln Ala Asn Phe Cys Ile Phe Met Xaa Arg Arg Gly Phe Thr
      50                  55                  60                
 Met Leu Ala Arg Met Val Ser Ile Ser Xaa Pro Arg Asp Leu Pro Ala
  65                  70                  75                  80
 Leu Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Ser His His Ala Pro
                  85                  90                  95    
 Pro Gln Met Asp Phe Thr Phe Ala Leu Leu Cys Phe Ala Leu Lys Gly
             100                 105                 110        
 Cys Leu Pro Arg Gln Lys Glu Gly Gly Thr Leu Asn Leu Ile
         115                 120                 125    



      <210> 2102
      <211> 199
      <212> PRT
      <213> Homo sapiens


      <400> 2102
 Pro Arg Cys Arg Asn Ser Ala Arg Val Ala Asp Thr Phe Tyr Thr Asn
   1               5                  10                  15    
 Ala Gly Cys Thr Leu Val Ala Leu Asn Pro Phe Lys Pro Val Pro Gln
              20                  25                  30        
 Leu Tyr Ser Pro Glu Leu Met Arg Glu Tyr His Ala Ala Pro Gln Pro
          35                  40                  45            
 Gln Lys Leu Lys Pro His Val Phe Thr Val Gly Glu Gln Thr Tyr Arg
      50                  55                  60                
 Asn Val Lys Ser Leu Ile Glu Pro Val Asn Gln Ser Ile Val Val Ser
  65                  70                  75                  80
 Gly Glu Ser Gly Ala Gly Lys Thr Trp Thr Ser Arg Cys Leu Met Lys
                  85                  90                  95    
 Phe Tyr Ala Val Val Ala Thr Ser Pro Ala Ser Trp Glu Ser His Lys
             100                 105                 110        
 Ile Ala Glu Arg Ile Glu Gln Arg Ile Leu Asn Ser Asn Pro Val Met
         115                 120                 125            
 Glu Ala Phe Gly Asn Ala Cys Thr Leu Arg Asn Asn Asn Ser Ser Arg
     130                 135                 140                
 Phe Gly Lys Phe Ile Gln Leu Gln Leu Asn Arg Ala Gln Gln Met Thr
 145                 150                 155                 160
 Gly Ala Ala Val Gln Thr Tyr Leu Leu Glu Lys Thr Arg Val Ala Cys
                 165                 170                 175    
 Gln Ala Ser Ser Glu Arg Asn Lys Asp Pro Ile Pro Pro Glu Leu Thr
             180                 185                 190        
 Arg Leu Leu Gln Gln Ser Gln
         195                



      <210> 2103
      <211> 199
      <212> PRT
      <213> Homo sapiens


      <400> 2103
 Pro Arg Cys Arg Asn Ser Ala Arg Val Ala Asp Thr Phe Tyr Thr Asn
   1               5                  10                  15    
 Ala Gly Cys Thr Leu Val Ala Leu Asn Pro Phe Lys Pro Val Pro Gln
              20                  25                  30        
 Leu Tyr Ser Pro Glu Leu Met Arg Glu Tyr His Ala Ala Pro Gln Pro
          35                  40                  45            
 Gln Lys Leu Lys Pro His Val Phe Thr Val Gly Glu Gln Thr Tyr Arg
      50                  55                  60                
 Asn Val Lys Ser Leu Ile Glu Pro Val Asn Gln Ser Ile Val Val Ser
  65                  70                  75                  80
 Gly Glu Ser Gly Ala Gly Lys Thr Trp Thr Ser Arg Cys Leu Met Lys
                  85                  90                  95    
 Phe Tyr Ala Val Val Ala Thr Ser Pro Ala Ser Trp Glu Ser His Lys
             100                 105                 110        
 Ile Ala Glu Arg Ile Glu Gln Arg Ile Leu Asn Ser Asn Pro Val Met
         115                 120                 125            
 Glu Ala Phe Gly Asn Ala Cys Thr Leu Arg Asn Asn Asn Ser Ser Arg
     130                 135                 140                
 Phe Gly Lys Phe Ile Gln Leu Gln Leu Asn Arg Ala Gln Gln Met Thr
 145                 150                 155                 160
 Gly Ala Ala Val Gln Thr Tyr Leu Leu Glu Lys Thr Arg Val Ala Cys
                 165                 170                 175    
 Gln Ala Ser Ser Glu Arg Asn Lys Asp Pro Ile Pro Pro Glu Leu Thr
             180                 185                 190        
 Arg Leu Leu Gln Gln Ser Gln
         195                



      <210> 2104
      <211> 142
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(142)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2104
 Phe Lys Trp Leu Leu Lys Ser His Ala Ile Cys Phe Trp Thr Arg Ser
   1               5                  10                  15    
 Xaa Ser Tyr Cys Asp Asn Val Cys Val Pro Ser Leu Trp Ala His His
              20                  25                  30        
 Leu Gly Ile Arg Thr Glu Ile Pro Glu Phe Phe Leu Ser Lys Phe Leu
          35                  40                  45            
 Cys Thr Ser Ile Ile Pro His Phe Thr Tyr Arg Arg Gln Leu Arg Leu
      50                  55                  60                
 Ile Gln Gly Ser Thr Glu Xaa Glu Ala Xaa Glu Asp Lys Leu Glu Gln
  65                  70                  75                  80
 Lys Xaa Ala Leu Gly Ala Ala Gln Phe Thr Leu Pro Gly Met Asp Val
                  85                  90                  95    
 Phe Val Cys Phe Val Phe Cys Phe Cys Leu Phe Glu Met Glu Ser His
             100                 105                 110        
 Ser Val Thr Xaa Ala Arg Val Gln Trp Cys Asp Leu Gly Ser Leu Gln
         115                 120                 125            
 Pro Leu Pro Leu Gly Phe Lys Gln Phe Ser Cys Leu Gly Leu
     130                 135                 140        



      <210> 2105
      <211> 380
      <212> PRT
      <213> Homo sapiens


      <400> 2105
 Cys Gln Arg Arg Glu Asp Ala Ala Glu Phe Trp Leu Cys Phe Ala Leu
   1               5                  10                  15    
 Asp Pro Ser Lys Asp Pro Cys Leu Lys Val Lys Cys Ser Pro His Lys
              20                  25                  30        
 Val Cys Val Thr Gln Asp Tyr Gln Thr Ala Leu Cys Val Ser Arg Lys
          35                  40                  45            
 His Leu Leu Pro Arg Gln Lys Lys Gly Asn Val Ala Gln Lys His Trp
      50                  55                  60                
 Val Gly Pro Ser Asn Leu Val Lys Cys Lys Pro Cys Pro Val Ala Gln
  65                  70                  75                  80
 Ser Ala Met Val Cys Gly Ser Asp Gly His Ser Tyr Thr Ser Lys Cys
                  85                  90                  95    
 Lys Leu Glu Phe His Ala Cys Ser Thr Gly Lys Ser Leu Ala Thr Leu
             100                 105                 110        
 Cys Asp Gly Pro Cys Pro Cys Leu Pro Glu Pro Glu Pro Pro Lys His
         115                 120                 125            
 Lys Gly Arg Lys Gly Val Pro Cys Thr Asp Lys Glu Leu Arg Asn Leu
     130                 135                 140                
 Ala Ser Arg Leu Lys Asp Trp Phe Gly Ala Leu His Glu Asp Ala Asn
 145                 150                 155                 160
 Arg Val Ile Lys Pro Thr Ser Ser Asn Thr Ala Gln Gly Arg Phe Asp
                 165                 170                 175    
 Thr Ser Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp Met Leu Asn
             180                 185                 190        
 Lys Leu Asp Met Asn Tyr Asp Leu Leu Leu Asp Pro Ser Glu Ile Asn
         195                 200                 205            
 Ala Ile Tyr Leu Asp Lys Tyr Glu Pro Cys Ile Lys Pro Leu Phe Asn
     210                 215                 220                
 Ser Cys Asp Ser Phe Lys Asp Gly Lys Pro Phe Leu Asn Asn Glu Trp
 225                 230                 235                 240
 Cys Leu Leu Pro Ser Gln Asn Pro Gly Gly Leu Pro Cys Ala Gln Asn
                 245                 250                 255    
 Glu Met Asn Arg Ile Gln Lys Leu Ser Lys Gly Lys Ser Leu Leu Gly
             260                 265                 270        
 Ala Phe Ile Pro Arg Cys Asn Glu Glu Gly Tyr Tyr Lys Ala Thr Gln
         275                 280                 285            
 Cys His Gly Ser Thr Gly Gln Cys Trp Cys Val Asp Lys Tyr Gly Asn
     290                 295                 300                
 Glu Leu Ala Gly Ser Arg Lys Gln Gly Ala Val Ser Cys Glu Glu Glu
 305                 310                 315                 320
 Gln Glu Thr Ser Gly Asp Phe Gly Ser Gly Gly Ser Val Val Leu Leu
                 325                 330                 335    
 Asp Asp Leu Glu Tyr Glu Arg Glu Leu Gly Pro Lys Asp Lys Glu Gly
             340                 345                 350        
 Lys Leu Arg Val His Thr Arg Ala Val Thr Glu Asp Asp Glu Asp Glu
         355                 360                 365            
 Asp Asp Asp Lys Glu Asp Glu Val Gly Tyr Ile Trp
     370                 375                 380



      <210> 2106
      <211> 228
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(228)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2106
 Met Leu Asn Leu Ala Phe Thr Val Gly Ser Phe Leu Leu Ser Ala Ile
   1               5                  10                  15    
 Thr Leu Pro Leu Gly Ile Val Met Asp Lys Tyr Gly Pro Arg Lys Leu
              20                  25                  30        
 Arg Leu Leu Gly Ser Ala Cys Phe Ala Val Ser Cys Leu Leu Ile Ala
          35                  40                  45            
 Tyr Gly Ala Ser Lys Pro Asn Ala Leu Ser Val Leu Ile Phe Ile Ala
      50                  55                  60                
 Leu Ala Leu Asn Gly Phe Gly Gly Met Cys Met Thr Phe Thr Ser Leu
  65                  70                  75                  80
 Thr Leu Pro Asn Met Phe Gly Asp Leu Arg Phe Thr Phe Ile Ala Leu
                  85                  90                  95    
 Met Ile Gly Ser Tyr Ala Ser Ser Ala Val Thr Phe Pro Gly Ile Lys
             100                 105                 110        
 Leu Ile Tyr Asp Ala Gly Val Ser Phe Ile Val Val Leu Val Val Trp
         115                 120                 125            
 Ala Gly Cys Ser Gly Leu Val Phe Leu Asn Cys Phe Phe Asn Trp Pro
     130                 135                 140                
 Leu Glu Pro Phe Pro Gly Pro Glu Asp Met Asp Tyr Ser Val Lys Ile
 145                 150                 155                 160
 Lys Phe Ser Trp Leu Gly Phe Asp His Lys Ile Thr Gly Lys Gln Phe
                 165                 170                 175    
 Tyr Lys Gln Val Thr Thr Val Gly Arg Arg Leu Ser Val Gly Ser Ser
             180                 185                 190        
 Met Arg Ser Ala Lys Glu Gln Val Ala Leu Gln Glu Gly His Lys Leu
         195                 200                 205            
 Cys Leu Ser Thr Val Asp Arg Asn Ser Xaa Arg Ser Xaa Ala Leu Val
     210                 215                 220                
 Ser Gly Tyr Pro
 225            



      <210> 2107
      <211> 228
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(228)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2107
 Met Leu Asn Leu Ala Phe Thr Val Gly Ser Phe Leu Leu Ser Ala Ile
   1               5                  10                  15    
 Thr Leu Pro Leu Gly Ile Val Met Asp Lys Tyr Gly Pro Arg Lys Leu
              20                  25                  30        
 Arg Leu Leu Gly Ser Ala Cys Phe Ala Val Ser Cys Leu Leu Ile Ala
          35                  40                  45            
 Tyr Gly Ala Ser Lys Pro Asn Ala Leu Ser Val Leu Ile Phe Ile Ala
      50                  55                  60                
 Leu Ala Leu Asn Gly Phe Gly Gly Met Cys Met Thr Phe Thr Ser Leu
  65                  70                  75                  80
 Thr Leu Pro Asn Met Phe Gly Asp Leu Arg Phe Thr Phe Ile Ala Leu
                  85                  90                  95    
 Met Ile Gly Ser Tyr Ala Ser Ser Ala Val Thr Phe Pro Gly Ile Lys
             100                 105                 110        
 Leu Ile Tyr Asp Ala Gly Val Ser Phe Ile Val Val Leu Val Val Trp
         115                 120                 125            
 Ala Gly Cys Ser Gly Leu Val Phe Leu Asn Cys Phe Phe Asn Trp Pro
     130                 135                 140                
 Leu Glu Pro Phe Pro Gly Pro Glu Asp Met Asp Tyr Ser Val Lys Ile
 145                 150                 155                 160
 Lys Phe Ser Trp Leu Gly Phe Asp His Lys Ile Thr Gly Lys Gln Phe
                 165                 170                 175    
 Tyr Lys Gln Val Thr Thr Val Gly Arg Arg Leu Ser Val Gly Ser Ser
             180                 185                 190        
 Met Arg Ser Ala Lys Glu Gln Val Ala Leu Gln Glu Gly His Lys Leu
         195                 200                 205            
 Cys Leu Ser Thr Val Asp Arg Asn Ser Xaa Arg Ser Xaa Ala Leu Val
     210                 215                 220                
 Ser Gly Tyr Pro
 225            



      <210> 2108
      <211> 190
      <212> PRT
      <213> Homo sapiens


      <400> 2108
 Tyr Ala Ala Phe Gly Ala Val Val Thr Arg Val Ser Leu Pro Ala Pro
   1               5                  10                  15    
 Arg Cys Pro Ala Leu Gly Gly Leu Ala Ser Gly Pro Gly Glu Ser Gly
              20                  25                  30        
 Pro Ala Leu Leu Gln Val Cys Gly Ala Lys Cys Pro Gly Gly Ala Pro
          35                  40                  45            
 Arg Gly Glu Asn Arg Glu Lys Glu Glu Thr Thr Arg Ile Gly Pro Gly
      50                  55                  60                
 Val Met Glu Ser Lys Glu Lys Arg Ala Val Asn Ser Leu Ser Met Glu
  65                  70                  75                  80
 Asn Ala Asn Gln Glu Asn Glu Glu Lys Glu Gln Val Ala Asn Lys Gly
                  85                  90                  95    
 Glu Pro Leu Ala Leu Pro Leu Asp Ala Gly Glu Tyr Cys Val Pro Arg
             100                 105                 110        
 Gly Asn Arg Arg Arg Phe Arg Val Arg Gln Pro Ile Leu Gln Tyr Arg
         115                 120                 125            
 Trp Asp Met Met His Arg Leu Gly Glu Pro Gln Ala Arg Met Arg Glu
     130                 135                 140                
 Glu Asn Met Glu Arg Ile Gly Glu Glu Val Arg Gln Leu Met Glu Lys
 145                 150                 155                 160
 Leu Arg Glu Lys Gln Leu Ser His Ser Leu Arg Ala Val Ser Thr Asp
                 165                 170                 175    
 Pro Pro His His Asp His His Asp Glu Phe Cys Leu Met Pro
             180                 185                 190



      <210> 2109
      <211> 308
      <212> PRT
      <213> Homo sapiens


      <400> 2109
 Ser Glu Gln Lys Ile Gln Glu Gln Gly Tyr Val Trp Ile Thr Val Phe
   1               5                  10                  15    
 Ser Ala Leu Pro Thr Thr Val Ser Ala Leu His Pro Arg Val Leu Lys
              20                  25                  30        
 Pro Leu Ser Ser Leu Ile His Leu Gln Ala Asn Ser Asn Pro Trp Glu
          35                  40                  45            
 Cys Asn Cys Lys Leu Leu Gly Leu Arg Asp Trp Leu Ala Ser Ser Ala
      50                  55                  60                
 Ile Thr Leu Asn Ile Tyr Trp Gln Asn Pro Pro Ser Met Arg Gly Arg
  65                  70                  75                  80
 Ala Leu Arg Tyr Ile Asn Ile Thr Asn Cys Val Thr Ser Ser Ile Asn
                  85                  90                  95    
 Val Ser Arg Ala Trp Ala Val Val Lys Ser Pro His Ile His His Lys
             100                 105                 110        
 Thr Thr Ala Leu Met Met Ala Trp His Lys Val Thr Thr Asn Gly Ser
         115                 120                 125            
 Pro Leu Glu Asn Thr Glu Thr Glu Asn Ile Thr Phe Trp Glu Arg Ile
     130                 135                 140                
 Pro Thr Ser Pro Ala Gly Arg Phe Phe Gln Glu Asn Ala Phe Gly Asn
 145                 150                 155                 160
 Pro Leu Glu Thr Thr Ala Val Leu Pro Val Gln Ile Gln Leu Thr Thr
                 165                 170                 175    
 Ser Val Thr Leu Asn Leu Glu Lys Asn Ser Ala Leu Pro Asn Asp Ala
             180                 185                 190        
 Ala Ser Met Ser Gly Lys Thr Ser Leu Ile Cys Thr Gln Glu Val Glu
         195                 200                 205            
 Lys Leu Asn Glu Ala Phe Asp Ile Leu Leu Ala Phe Phe Ile Leu Ala
     210                 215                 220                
 Cys Val Leu Ile Ile Phe Leu Ile Tyr Lys Val Val Gln Phe Lys Gln
 225                 230                 235                 240
 Lys Leu Lys Ala Ser Glu Asn Ser Arg Glu Asn Arg Leu Glu Tyr Tyr
                 245                 250                 255    
 Ser Phe Tyr Gln Ser Ala Arg Tyr Asn Val Thr Ala Ser Ile Cys Asn
             260                 265                 270        
 Thr Ser Pro Asn Ser Leu Glu Ser Pro Gly Leu Glu Gln Ile Arg Leu
         275                 280                 285            
 His Lys Gln Ile Val Pro Glu Asn Glu Ala Gln Val Ile Leu Phe Glu
     290                 295                 300                
 His Ser Ala Leu
 305            



      <210> 2110
      <211> 45
      <212> PRT
      <213> Homo sapiens


      <400> 2110
 Met Ile Leu Cys His Leu Met Gln Ala Pro Tyr His Leu Lys Val Ser
   1               5                  10                  15    
 Trp Glu Pro Thr Asp Pro Pro Thr Leu Trp Lys Cys Trp Thr Asn Val
              20                  25                  30        
 Ser Thr Asn Pro Pro Leu Ser Ala Leu Arg Gly His Arg
          35                  40                  45



      <210> 2111
      <211> 316
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(316)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2111
 Pro Arg Val Arg Pro Arg Val Arg Pro Arg Val Arg Ser Ser Arg Pro
   1               5                  10                  15    
 Arg Ser Arg Asp Pro Ser Pro Arg Arg Ala Arg Leu Arg Trp Gln Leu
              20                  25                  30        
 Arg Trp Lys Pro Arg Trp Cys Pro Arg Pro Pro Lys Thr Pro Gly Val
          35                  40                  45            
 Trp Lys Arg Pro Arg Thr Arg Pro Arg Ser Ser Ala Gly Gly Ser Thr
      50                  55                  60                
 Gly Phe Pro Ser Ser Pro Ile Leu Arg Arg Ser Pro Ser Thr Arg Arg
  65                  70                  75                  80
 Arg Ser Ser Arg Lys Ala Ser Pro Thr Ala Thr Arg Ala Thr Gly Thr
                  85                  90                  95    
 Pro Pro Arg Gln Ala Gln Arg Lys Thr Ala Arg Ala Ala Gly Arg Arg
             100                 105                 110        
 Arg Ala Ser Pro Gly Ile Ala Thr Ala Gly Thr Arg Ser Met Ile Ser
         115                 120                 125            
 Met Arg Pro Gly Arg Lys Pro Ser Asn Pro Ser Trp Glu Gly Arg Thr
     130                 135                 140                
 Asn Glu Glu Thr Ser Ser Leu Ser Arg Leu Lys Pro Val Ser Pro Gly
 145                 150                 155                 160
 Thr Ile Thr Cys Pro Leu Arg Thr Pro Gly Ser Leu Leu Lys Asp Ser
                 165                 170                 175    
 Lys Ile Pro Ile Ser Ile Lys His Leu Thr Asn Leu Pro Ser Ser His
             180                 185                 190        
 Pro Val Val His Gln Gln Pro Ser Arg Ser Glu Met Pro Arg Thr Lys
         195                 200                 205            
 Ile Pro Val Ser Lys Val Leu Val Arg Arg Val Ser Asn Arg Gly Leu
     210                 215                 220                
 Ala Gly Thr Thr Ile Arg Ala Thr Ala Cys His Asp Ser Ala Gln Lys
 225                 230                 235                 240
 Val Val Arg Ser Ser Arg Pro Arg Trp Met Gly Pro Met Pro Arg Asn
                 245                 250                 255    
 Thr Thr Phe Pro Trp Glu Thr Thr Lys Val Ser Phe Ala Phe Pro Lys
             260                 265                 270        
 Glu Ser Leu Leu Trp Thr Pro Pro Val Pro Arg Pro Ala Pro Glu Arg
         275                 280                 285            
 Gly Pro Arg Arg Ser Leu Cys Pro Glu Xaa Gly Pro Asp Asn Thr Arg
     290                 295                 300                
 Lys Arg Asp Ala Thr Arg Gly Phe Leu Leu Ser Arg
 305                 310                 315    



      <210> 2112
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 2112
 Met Leu Val Leu Leu Pro Arg Ser Lys Ala Met Pro Leu Leu Ser Val
   1               5                  10                  15    
 Asn Val Thr Leu Ala Phe Phe Pro Arg Asn Lys Glu Ile Val Lys Tyr
              20                  25                  30        
 Leu Leu Asn Gln Gly Ala Asp Val Thr Leu Arg Ala Lys Asn Gly Tyr
          35                  40                  45            
 Thr Ala Phe Asp Leu Val Met Leu Leu Asn Asp Pro Asp Ile Phe Gly
      50                  55                  60                
 Gly Glu Leu Ile Gly Phe Leu Ser Val Val Thr Glu Leu Val Arg Leu
  65                  70                  75                  80
 Leu Ala Ser Val Phe Met Gln Val Asn Lys Asp Ile Gly Arg Arg Ser
                  85                  90                  95    
 His Gln Leu Pro Leu Pro His Ser Lys Val Pro Thr Ala Leu Glu His
             100                 105                 110        
 Pro Ser Ala Ala Arg
         115        



      <210> 2113
      <211> 351
      <212> PRT
      <213> Homo sapiens


      <400> 2113
 Pro Arg Arg Met Gly Ser Trp Val Gln Leu Ile Thr Ser Val Gly Val
   1               5                  10                  15    
 Gln Gln Asn His Pro Gly Trp Thr Val Ala Gly Gln Phe Gln Glu Lys
              20                  25                  30        
 Lys Arg Phe Thr Glu Glu Val Ile Glu Tyr Phe Gln Lys Lys Val Ser
          35                  40                  45            
 Pro Val His Leu Lys Ile Leu Leu Thr Ser Asp Glu Ala Trp Lys Arg
      50                  55                  60                
 Phe Val Arg Val Ala Glu Leu Pro Arg Glu Glu Ala Asp Ala Leu Tyr
  65                  70                  75                  80
 Glu Ala Leu Lys Asn Leu Thr Pro Tyr Val Ala Ile Glu Asp Lys Asp
                  85                  90                  95    
 Met Gln Gln Lys Glu Gln Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe
             100                 105                 110        
 Pro Gln Ile Arg Trp Lys Ile Gln Glu Ser Ile Glu Arg Leu Arg Val
         115                 120                 125            
 Ile Ala Asn Glu Ile Glu Lys Val His Arg Gly Cys Val Ile Ala Asn
     130                 135                 140                
 Val Val Ser Gly Ser Thr Gly Ile Leu Ser Val Ile Gly Val Met Leu
 145                 150                 155                 160
 Ala Pro Phe Thr Ala Gly Leu Ser Leu Ser Ile Thr Ala Ala Gly Val
                 165                 170                 175    
 Gly Leu Gly Ile Ala Ser Ala Thr Ala Gly Ile Ala Ser Ser Ile Val
             180                 185                 190        
 Glu Asn Thr Tyr Thr Arg Ser Ala Glu Leu Thr Ala Ser Arg Leu Thr
         195                 200                 205            
 Ala Thr Ser Thr Asp Gln Leu Glu Ala Leu Arg Asp Ile Leu His Asp
     210                 215                 220                
 Ile Thr Pro Asn Val Leu Ser Phe Ala Leu Asp Phe Asp Glu Ala Thr
 225                 230                 235                 240
 Lys Met Ile Ala Asn Asp Val His Thr Leu Arg Arg Ser Lys Ala Thr
                 245                 250                 255    
 Val Gly Arg Pro Leu Ile Ala Trp Arg Tyr Val Pro Ile Asn Val Val
             260                 265                 270        
 Glu Thr Leu Arg Thr Arg Gly Ala Pro Thr Arg Ile Val Arg Lys Val
         275                 280                 285            
 Ala Arg Asn Leu Gly Lys Ala Thr Ser Gly Val Leu Val Val Leu Asp
     290                 295                 300                
 Val Val Asn Leu Val Gln Asp Ser Leu Asp Leu His Lys Gly Glu Lys
 305                 310                 315                 320
 Ser Glu Ser Ala Glu Leu Leu Arg Gln Trp Ala Gln Glu Leu Glu Glu
                 325                 330                 335    
 Asn Leu Asn Glu Leu Thr His Ile His Gln Ser Leu Lys Ala Gly
             340                 345                 350    



      <210> 2114
      <211> 351
      <212> PRT
      <213> Homo sapiens


      <400> 2114
 Pro Arg Arg Met Gly Ser Trp Val Gln Leu Ile Thr Ser Val Gly Val
   1               5                  10                  15    
 Gln Gln Asn His Pro Gly Trp Thr Val Ala Gly Gln Phe Gln Glu Lys
              20                  25                  30        
 Lys Arg Phe Thr Glu Glu Val Ile Glu Tyr Phe Gln Lys Lys Val Ser
          35                  40                  45            
 Pro Val His Leu Lys Ile Leu Leu Thr Ser Asp Glu Ala Trp Lys Arg
      50                  55                  60                
 Phe Val Arg Val Ala Glu Leu Pro Arg Glu Glu Ala Asp Ala Leu Tyr
  65                  70                  75                  80
 Glu Ala Leu Lys Asn Leu Thr Pro Tyr Val Ala Ile Glu Asp Lys Asp
                  85                  90                  95    
 Met Gln Gln Lys Glu Gln Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe
             100                 105                 110        
 Pro Gln Ile Arg Trp Lys Ile Gln Glu Ser Ile Glu Arg Leu Arg Val
         115                 120                 125            
 Ile Ala Asn Glu Ile Glu Lys Val His Arg Gly Cys Val Ile Ala Asn
     130                 135                 140                
 Val Val Ser Gly Ser Thr Gly Ile Leu Ser Val Ile Gly Val Met Leu
 145                 150                 155                 160
 Ala Pro Phe Thr Ala Gly Leu Ser Leu Ser Ile Thr Ala Ala Gly Val
                 165                 170                 175    
 Gly Leu Gly Ile Ala Ser Ala Thr Ala Gly Ile Ala Ser Ser Ile Val
             180                 185                 190        
 Glu Asn Thr Tyr Thr Arg Ser Ala Glu Leu Thr Ala Ser Arg Leu Thr
         195                 200                 205            
 Ala Thr Ser Thr Asp Gln Leu Glu Ala Leu Arg Asp Ile Leu His Asp
     210                 215                 220                
 Ile Thr Pro Asn Val Leu Ser Phe Ala Leu Asp Phe Asp Glu Ala Thr
 225                 230                 235                 240
 Lys Met Ile Ala Asn Asp Val His Thr Leu Arg Arg Ser Lys Ala Thr
                 245                 250                 255    
 Val Gly Arg Pro Leu Ile Ala Trp Arg Tyr Val Pro Ile Asn Val Val
             260                 265                 270        
 Glu Thr Leu Arg Thr Arg Gly Ala Pro Thr Arg Ile Val Arg Lys Val
         275                 280                 285            
 Ala Arg Asn Leu Gly Lys Ala Thr Ser Gly Val Leu Val Val Leu Asp
     290                 295                 300                
 Val Val Asn Leu Val Gln Asp Ser Leu Asp Leu His Lys Gly Glu Lys
 305                 310                 315                 320
 Ser Glu Ser Ala Glu Leu Leu Arg Gln Trp Ala Gln Glu Leu Glu Glu
                 325                 330                 335    
 Asn Leu Asn Glu Leu Thr His Ile His Gln Ser Leu Lys Ala Gly
             340                 345                 350    



      <210> 2115
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 2115
 Val Pro Arg Leu Val Ser Pro Leu Ser Asn Pro Ala Pro Lys Phe Tyr
   1               5                  10                  15    
 Cys Val Ser Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu
              20                  25                  30        
 Asn Leu Leu Val Arg Ser Arg Asn Lys Gly Ala Leu Asp Thr His Ala
          35                  40                  45            
 Trp Ser Leu Ser Gly Asn Lys Gly Asn Val Trp Gln Gln Ala His Val
      50                  55                  60                
 Pro Ile Ser Pro Ser Gly Pro Phe Gln Ile Ile Phe Glu Gly Val Arg
  65                  70                  75                  80
 Gly Pro Gly Tyr Leu Gly Asp Ile Ala Ile Asp Asp Val Thr Leu Lys
                  85                  90                  95    
 Lys Gly Glu Cys Pro Arg Lys Gln Thr Asp Pro Asn Lys Val Val Val
             100                 105                 110        
 Met Pro Gly Ser Gly Ala Pro Cys Gln Ser Ser Pro Gln Leu Trp Gly
         115                 120                 125            
 Pro Met Ala Ile Phe Leu Leu Ala Leu Gln Arg
     130                 135                



      <210> 2116
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 2116
 Val Pro Arg Leu Val Ser Pro Leu Ser Asn Pro Ala Pro Lys Phe Tyr
   1               5                  10                  15    
 Cys Val Ser Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu
              20                  25                  30        
 Asn Leu Leu Val Arg Ser Arg Asn Lys Gly Ala Leu Asp Thr His Ala
          35                  40                  45            
 Trp Ser Leu Ser Gly Asn Lys Gly Asn Val Trp Gln Gln Ala His Val
      50                  55                  60                
 Pro Ile Ser Pro Ser Gly Pro Phe Gln Ile Ile Phe Glu Gly Val Arg
  65                  70                  75                  80
 Gly Pro Gly Tyr Leu Gly Asp Ile Ala Ile Asp Asp Val Thr Leu Lys
                  85                  90                  95    
 Lys Gly Glu Cys Pro Arg Lys Gln Thr Asp Pro Asn Lys Val Val Val
             100                 105                 110        
 Met Pro Gly Ser Gly Ala Pro Cys Gln Ser Ser Pro Gln Leu Trp Gly
         115                 120                 125            
 Pro Met Ala Ile Phe Leu Leu Ala Leu Gln Arg
     130                 135                



      <210> 2117
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 2117
 Met Val Leu Pro Phe Ile Cys Asn Leu Leu Arg Arg His Pro Ala Cys
   1               5                  10                  15    
 Arg Val Leu Val His Arg Pro His Gly Pro Glu Leu Asp Ala Asp Pro
              20                  25                  30        
 Tyr Asp Pro Gly Glu Glu Asp Pro Ala Gln Ser Arg Ala Leu Glu Ser
          35                  40                  45            
 Ser Leu Trp Glu Leu Gln Ala Leu Gln Arg His Tyr His Pro Glu Val
      50                  55                  60                
 Ser Lys Ala Ala Ser Val Ile Asn Gln Ala Leu Ser Met Pro Glu Val
  65                  70                  75                  80
 Ser Ile Ala Pro Leu Leu Glu Leu Thr Ala Tyr Glu Ile Phe Glu Arg
                  85                  90                  95    
 Asp Leu Lys Lys Lys Gly Pro Glu Pro Val Pro Thr Gly Val Leu Ser
             100                 105                 110        
 Gln Pro Arg Ala Cys Trp Asp Gly Arg Val Lys Leu Cys Ala Gln His
         115                 120                 125            
 Phe His Ala Gln Leu Thr Leu Ala His Leu
     130                 135            



      <210> 2118
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 2118
 Val His Val Cys Ser Ser Lys Met Gly Ala Leu Ser Thr Glu Arg Leu
   1               5                  10                  15    
 Gln Tyr Tyr Thr Gln Glu Leu Gly Val Arg Glu Arg Ser Gly His Ser
              20                  25                  30        
 Val Ser Leu Ile Asp Leu Trp Gly Leu Leu Val Glu Tyr Leu Leu Tyr
          35                  40                  45            
 Gln Glu Glu Asn Pro Ala Lys Leu Ser Asp Gln Gln Glu Ala Val Arg
      50                  55                  60                
 Gln Gly Gln Asn Pro Tyr Pro Ile Tyr Thr Ser Val Asn Val Arg Thr
  65                  70                  75                  80
 Asn Leu Ser Gly Glu Asp Phe Ala Glu Trp Cys Glu Phe Thr Pro Tyr
                  85                  90                  95    
 Glu Val Gly Phe Pro Lys Tyr Gly Ala Tyr Val Pro Thr Glu Leu Phe
             100                 105                 110        
 Gly Ser Glu Leu Phe Met Gly Arg Leu Leu Gln Leu Gln Pro Glu Pro
         115                 120                 125            
 Arg Ile Cys Tyr Leu Gln Gly Met Trp Gly Ser Ala Phe Ala Thr Ser
     130                 135                 140                
 Leu Asp Glu Ile Phe Leu Lys Thr Ala Gly Ser Gly Leu Ser Phe Leu
 145                 150                 155                 160
 Glu Trp Tyr Arg Gly Ser Val Asn Ile Thr Asp Asp Cys Gln Lys Pro
                 165                 170                 175    
 Gln Leu His Asn
             180



      <210> 2119
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 2119
 Val His Val Cys Ser Ser Lys Met Gly Ala Leu Ser Thr Glu Arg Leu
   1               5                  10                  15    
 Gln Tyr Tyr Thr Gln Glu Leu Gly Val Arg Glu Arg Ser Gly His Ser
              20                  25                  30        
 Val Ser Leu Ile Asp Leu Trp Gly Leu Leu Val Glu Tyr Leu Leu Tyr
          35                  40                  45            
 Gln Glu Glu Asn Pro Ala Lys Leu Ser Asp Gln Gln Glu Ala Val Arg
      50                  55                  60                
 Gln Gly Gln Asn Pro Tyr Pro Ile Tyr Thr Ser Val Asn Val Arg Thr
  65                  70                  75                  80
 Asn Leu Ser Gly Glu Asp Phe Ala Glu Trp Cys Glu Phe Thr Pro Tyr
                  85                  90                  95    
 Glu Val Gly Phe Pro Lys Tyr Gly Ala Tyr Val Pro Thr Glu Leu Phe
             100                 105                 110        
 Gly Ser Glu Leu Phe Met Gly Arg Leu Leu Gln Leu Gln Pro Glu Pro
         115                 120                 125            
 Arg Ile Cys Tyr Leu Gln Gly Met Trp Gly Ser Ala Phe Ala Thr Ser
     130                 135                 140                
 Leu Asp Glu Ile Phe Leu Lys Thr Ala Gly Ser Gly Leu Ser Phe Leu
 145                 150                 155                 160
 Glu Trp Tyr Arg Gly Ser Val Asn Ile Thr Asp Asp Cys Gln Lys Pro
                 165                 170                 175    
 Gln Leu His Asn
             180



      <210> 2120
      <211> 507
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(507)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2120
 Pro His Pro Ser Gly Pro Arg Ile Thr His Ser His Ala Arg Glu Thr
   1               5                  10                  15    
 Ala Cys Gln Pro Gly Ser Glu Gln His Pro Gly Pro His Gly Gly Gln
              20                  25                  30        
 Leu Pro Arg Gly Gly Arg Gln Gly Pro Glu Leu Pro Ser His Val Cys
          35                  40                  45            
 Arg Ala Gln Ala Gly Arg Thr Gly Gln Glu Pro Ser Ser Glu Arg Pro
      50                  55                  60                
 His Ala Gly Gln Gly Ala Gly Leu Trp Ser Gly Ser Pro Trp Gly Arg
  65                  70                  75                  80
 Gly Arg Thr Gln Pro Thr His Ala Pro Thr Glu Gly Ala Thr Pro Arg
                  85                  90                  95    
 Cys Pro Leu Arg Pro Ser Pro Arg Gly Ser Gly Arg Ala Gly Pro Thr
             100                 105                 110        
 Leu Ile Arg Ala Gly Leu Ser Gly Gly Arg Gly Gly Arg Ser Leu Cys
         115                 120                 125            
 Pro Cys Gly Phe Pro Arg Ala Gly Ala Val Pro Ala Arg Ser Ser His
     130                 135                 140                
 Asn Gln Thr Ser Pro Val His Glu Lys Ser Arg His Gly Pro Thr Ala
 145                 150                 155                 160
 Ser Gly Pro Gly Cys Trp Trp Leu Gly Asp Pro Gln Gly Arg Arg Val
                 165                 170                 175    
 Pro Gly Leu Ala Val Pro Xaa Ala Pro Ala Ala Gly Thr Pro Met Asp
             180                 185                 190        
 Lys Leu Pro Gly Leu His Leu Pro Glu Gln Arg Leu Pro Ser Ile Gly
         195                 200                 205            
 Gly Pro Phe Ser Ala Gly Leu Ser Pro Ser Gly Gln Ser Arg Glu Trp
     210                 215                 220                
 Gln Gly Gly Ser Gln Gly Ser Arg Ser Arg Gln Phe Ser Lys Lys Ala
 225                 230                 235                 240
 Pro Gly Pro Pro Pro Ser Thr Gly Gly Gly Cys Leu Gly Cys Gly Gly
                 245                 250                 255    
 Arg Gly Thr Arg Gly Ser Ala His Ala Gly Pro Trp Gly Ser Pro His
             260                 265                 270        
 Gln Gln Gly Ser Xaa Gly Ala Pro Gly Ser Gln Ala Lys Gly Gly Thr
         275                 280                 285            
 Pro Xaa Arg Lys Pro Ala Pro Ala Asn Gly Ser Ser Glu Glu Gln Glu
     290                 295                 300                
 Glu Ala Arg Gly Pro Gln Gly Leu Glu Val Ser Ser Ser Gln Thr Ser
 305                 310                 315                 320
 Ala Ser His Ala Gly Leu Gly Leu Gln Gly Asn Ser Thr Arg Gly Val
                 325                 330                 335    
 Gly Pro Gly Pro Arg Pro Pro Ala Glu Pro Thr Thr Gly Arg Ser Trp
             340                 345                 350        
 Ala Arg Ser Arg Val Asn Pro Asp Xaa Glu Gln Ala Ser Gly Ala Xaa
         355                 360                 365            
 Val Arg Ser Gly Ser Arg Ser Pro Gly Asp Ala Leu Glu Ser Ser Cys
     370                 375                 380                
 Asn Ala Pro Ala Trp Leu Gln Leu Cys Ser Ala Pro Cys Ala Leu Gly
 385                 390                 395                 400
 Ser Arg Glu Pro Gly Gln Gly Leu Ala Val Thr Gln Thr Leu Cys Gly
                 405                 410                 415    
 Pro Gln Ser Leu Gly His Pro Arg Glu Ser His Lys Thr Arg Pro Arg
             420                 425                 430        
 Tyr Glu Ala Ala Thr Ser Ser Ala Cys Leu Gly Leu Ala Leu Thr Gly
         435                 440                 445            
 Thr Phe Ser Val Glu Glu Thr Glu Met Phe Met Thr Arg Gln Arg Pro
     450                 455                 460                
 Thr Gly Arg Asp Leu Gln Arg Gly Thr Arg Pro Gln Gly Trp Gln Gly
 465                 470                 475                 480
 Pro Val Pro Gly Thr Ser His Tyr Gly Arg Ala Arg Pro Ala Leu Gly
                 485                 490                 495    
 Glu Ala Ser Asp Lys Gln Glu Ala Asn Gly Ala
             500                 505        



      <210> 2121
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 2121
 Asp Asn His Pro Ser Phe Pro Arg Leu Pro Ser Ser Arg Pro Gly Thr
   1               5                  10                  15    
 Lys Glu Val Leu Lys Glu Ile His Ile Ser Asp Thr Thr Ala Asp Val
              20                  25                  30        
 Ile Phe Tyr Pro Ile Tyr Arg Met Ser Glu Met Ile Phe Arg Arg Ile
          35                  40                  45            
 Lys Met Pro Trp Leu Trp Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu
      50                  55                  60                
 Gly Trp Glu His Lys Lys Ser Leu Lys Ile Leu His Thr Phe Thr Asn
  65                  70                  75                  80
 Ser Val Ile Ala Glu Arg Ala Asn Glu Met Asn Ala Asn Glu Asp Cys
                  85                  90                  95    
 Arg Gly Asp Gly Arg Gly Ser Ala Pro Ser Lys Asn Lys Arg Arg Ala
             100                 105                 110        
 Phe Leu Asp Leu Leu Leu Ser Val Thr Asp Asp Glu Gly Asn Arg Leu
         115                 120                 125            
 Ser His Glu Asp Ile Arg Glu Glu Val Asp Thr Phe Met Phe Glu Val
     130                 135                 140                
 Leu Tyr Ile Val Arg Phe Arg Tyr His
 145                 150            



      <210> 2122
      <211> 371
      <212> PRT
      <213> Homo sapiens


      <400> 2122
 Pro Arg Val Arg Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln
   1               5                  10                  15    
 Trp Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val
              20                  25                  30        
 Ile Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser
          35                  40                  45            
 Gly His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu
      50                  55                  60                
 Thr Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser
  65                  70                  75                  80
 Leu Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val
                  85                  90                  95    
 Ser Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile
             100                 105                 110        
 Gln Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn
         115                 120                 125            
 Thr Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg
     130                 135                 140                
 Ser Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly
 145                 150                 155                 160
 Ala Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe
                 165                 170                 175    
 Val Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr
             180                 185                 190        
 Leu Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met
         195                 200                 205            
 Tyr Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala
     210                 215                 220                
 Phe Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val Ala
 225                 230                 235                 240
 Ser Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile
                 245                 250                 255    
 Pro Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys
             260                 265                 270        
 Gln Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro
         275                 280                 285            
 Gly His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp
     290                 295                 300                
 Leu Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys
 305                 310                 315                 320
 Glu Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly
                 325                 330                 335    
 Pro Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Gly His Ser
             340                 345                 350        
 Thr Pro His Thr Tyr Thr His Pro Pro Pro Ser Cys Gln Leu Asn Ser
         355                 360                 365            
 Ser His Ser
     370    



      <210> 2123
      <211> 371
      <212> PRT
      <213> Homo sapiens


      <400> 2123
 Pro Arg Val Arg Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln
   1               5                  10                  15    
 Trp Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val
              20                  25                  30        
 Ile Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser
          35                  40                  45            
 Gly His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu
      50                  55                  60                
 Thr Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser
  65                  70                  75                  80
 Leu Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val
                  85                  90                  95    
 Ser Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile
             100                 105                 110        
 Gln Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn
         115                 120                 125            
 Thr Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg
     130                 135                 140                
 Ser Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly
 145                 150                 155                 160
 Ala Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe
                 165                 170                 175    
 Val Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr
             180                 185                 190        
 Leu Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met
         195                 200                 205            
 Tyr Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala
     210                 215                 220                
 Phe Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val Ala
 225                 230                 235                 240
 Ser Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile
                 245                 250                 255    
 Pro Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys
             260                 265                 270        
 Gln Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro
         275                 280                 285            
 Gly His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp
     290                 295                 300                
 Leu Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys
 305                 310                 315                 320
 Glu Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly
                 325                 330                 335    
 Pro Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Gly His Ser
             340                 345                 350        
 Thr Pro His Thr Tyr Thr His Pro Pro Pro Ser Cys Gln Leu Asn Ser
         355                 360                 365            
 Ser His Ser
     370    



      <210> 2124
      <211> 371
      <212> PRT
      <213> Homo sapiens


      <400> 2124
 Pro Arg Val Arg Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln
   1               5                  10                  15    
 Trp Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val
              20                  25                  30        
 Ile Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser
          35                  40                  45            
 Gly His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu
      50                  55                  60                
 Thr Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser
  65                  70                  75                  80
 Leu Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val
                  85                  90                  95    
 Ser Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile
             100                 105                 110        
 Gln Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn
         115                 120                 125            
 Thr Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg
     130                 135                 140                
 Ser Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly
 145                 150                 155                 160
 Ala Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe
                 165                 170                 175    
 Val Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr
             180                 185                 190        
 Leu Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met
         195                 200                 205            
 Tyr Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala
     210                 215                 220                
 Phe Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val Ala
 225                 230                 235                 240
 Ser Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile
                 245                 250                 255    
 Pro Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys
             260                 265                 270        
 Gln Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro
         275                 280                 285            
 Gly His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp
     290                 295                 300                
 Leu Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys
 305                 310                 315                 320
 Glu Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly
                 325                 330                 335    
 Pro Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Gly His Ser
             340                 345                 350        
 Thr Pro His Thr Tyr Thr His Pro Pro Pro Ser Cys Gln Leu Asn Ser
         355                 360                 365            
 Ser His Ser
     370    



      <210> 2125
      <211> 212
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(212)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2125
 Pro Asn Trp Lys Arg Asn Pro Ser Leu Phe Xaa Lys Val Phe Pro Phe
   1               5                  10                  15    
 Met Lys Lys Val Val Gln Arg Gly Ser Leu Leu Pro Pro Lys Ser Leu
              20                  25                  30        
 Asp Tyr Asp Arg Phe Ser Arg Asn Asp Thr Pro Leu Gly Arg Val Ser
          35                  40                  45            
 Ile Pro Leu Asn Lys Val Asp Leu Thr Gln Met Gln Thr Phe Trp Lys
      50                  55                  60                
 Asp Leu Lys Pro Cys Ser Asp Gly Ser Gly Ser Arg Gly Glu Leu Leu
  65                  70                  75                  80
 Leu Ser Leu Cys Tyr Asn Pro Ser Ala Asn Ser Ile Ile Val Asn Ile
                  85                  90                  95    
 Ile Lys Ala Arg Asn Leu Lys Ala Met Asp Ile Gly Gly Thr Ser Asp
             100                 105                 110        
 Pro Tyr Val Lys Val Trp Leu Met Tyr Lys Asp Lys Arg Val Glu Lys
         115                 120                 125            
 Lys Lys Thr Val Thr Met Lys Arg Asn Leu Asn Pro Ile Phe Asn Glu
     130                 135                 140                
 Ser Phe Ala Phe Asp Ile Pro Thr Glu Lys Leu Arg Glu Thr Thr Ile
 145                 150                 155                 160
 Ile Ile Thr Val Met Asp Lys Asp Lys Leu Ser Arg Asn Asp Val Ile
                 165                 170                 175    
 Gly Lys Ile Tyr Leu Ser Trp Lys Ser Gly Pro Gly Glu Val Lys His
             180                 185                 190        
 Trp Lys Asp Met Ile Ala Arg Pro Arg Gln Pro Val Ala Gln Trp His
         195                 200                 205            
 Gln Leu Lys Ala
     210        



      <210> 2126
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 2126
 Ile Met Pro Cys Ala Gln Arg Ser Trp Leu Ala Asn Leu Ser Val Val
   1               5                  10                  15    
 Ala Gln Leu Leu Asn Phe Gly Ala Leu Cys Tyr Gly Arg Gln Pro Gln
              20                  25                  30        
 Pro Gly Pro Val Arg Phe Pro Asp Arg Arg Gln Glu His Phe Ile Lys
          35                  40                  45            
 Gly Leu Pro Glu Tyr His Val Val Gly Pro Val Arg Val Asp Ala Ser
      50                  55                  60                
 Gly His Phe Leu Ser Tyr Gly Leu His Tyr Pro Ile Thr Ser Ser Arg
  65                  70                  75                  80
 Arg Lys Arg Asp Leu Asp Gly Ser Glu Asp Trp Val Tyr Tyr Arg Ile
                  85                  90                  95    
 Phe His Glu Glu Lys Asp Leu Phe Phe Asn Leu Thr Val Asn Gln Gly
             100                 105                 110        
 Phe Leu Ser Asn Ser Tyr Ile Met Glu Lys Arg Tyr Gly Asn Leu Ser
         115                 120                 125            
 His Val Lys Met Met Ala Ser Ser Ala Pro Leu Cys His Leu Ser Gly
     130                 135                 140                
 Thr Val Leu Gln Gln Gly Thr Arg Val Gly Thr Ala Ala Leu Ser Ala
 145                 150                 155                 160
 Cys His Gly Leu Thr Gly Phe Phe Gln Leu Pro His Gly Asp Phe Phe
                 165                 170                 175    
 Ile Glu Pro Val Lys Lys His Pro Leu Val Glu Gly Gly Tyr His Pro
             180                 185                 190        
 His Ile Val Tyr Arg Arg Gln Lys Val Pro Glu Thr Lys Glu Pro Thr
         195                 200                 205            
 Cys Gly Leu Lys Gly Ile Val Thr His Met Ser Ser Trp Val Glu Glu
     210                 215                 220                
 Ser Val Leu Phe Phe Trp
 225                 230



      <210> 2127
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 2127
 Ile Lys Ser Lys Leu Asn Gln Gln Val Glu Val Gln Glu Ser Glu Trp
   1               5                  10                  15    
 Arg Leu Thr Glu Ala Lys Gly Pro Thr Met Gly Lys Glu Ser Gly Trp
              20                  25                  30        
 Asp Ser Gly Arg Ala Ala Val Ala Ala Val Val Gly Gly Val Val Ala
          35                  40                  45            
 Val Gly Thr Val Leu Val Ala Leu Ser Ala Met Gly Phe Thr Ser Val
      50                  55                  60                
 Gly Ile Ala Ala Ser Ser Ile Ala Ala Lys Met Met Ser Thr Ala Ala
  65                  70                  75                  80
 Ile Ala Asn Gly Gly Gly Val Ala Ala Gly Ser Leu Val Ala Ile Leu
                  85                  90                  95    
 Gln Ser Val Gly Ala Ala Gly Leu Ser Val Thr Ser Lys Val Ile Gly
             100                 105                 110        
 Gly Phe Ala Gly Thr Ala Leu Gly Ala Trp Leu Gly Ser Pro Pro Ser
         115                 120                 125            
 Ser
    



      <210> 2128
      <211> 247
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(247)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2128
 Ser Leu His Leu Ser Glu Arg Ala Asp Trp Gln Tyr Ser Gln Arg Ala
   1               5                  10                  15    
 Gly Asp Ala Val Glu Val Phe Phe Ser Arg Thr Ala Arg Asp Asn Arg
              20                  25                  30        
 Leu Gly Cys Met Phe Val Arg Cys Ala Pro Ser Ser Arg Tyr Thr Leu
          35                  40                  45            
 Leu Phe Ser His Gly Asn Ala Val Asp Leu Gly Gln Met Cys Ser Phe
      50                  55                  60                
 Tyr Ile Gly Leu Gly Ser Arg Ile Asn Cys Asn Ile Phe Ser Tyr Asp
  65                  70                  75                  80
 Tyr Ser Gly Tyr Gly Val Ser Ser Gly Lys Pro Ser Glu Lys Asn Leu
                  85                  90                  95    
 Tyr Ala Asp Ile Asp Ala Ala Trp Gln Ala Leu Arg Thr Arg Tyr Gly
             100                 105                 110        
 Val Ser Pro Glu Asn Ile Ile Leu Tyr Gly Gln Ser Ile Gly Thr Val
         115                 120                 125            
 Pro Thr Val Asp Leu Ala Ser Arg Tyr Glu Cys Ala Ala Val Ile Leu
     130                 135                 140                
 His Ser Pro Leu Met Ser Gly Leu Arg Val Ala Phe Pro Asp Thr Arg
 145                 150                 155                 160
 Lys Thr Tyr Cys Phe Asp Ala Phe Pro Ser Ile Asp Lys Ile Ser Lys
                 165                 170                 175    
 Val Thr Ser Pro Val Leu Val Ile His Gly Thr Glu Asp Glu Val Ile
             180                 185                 190        
 Asp Phe Ser His Gly Leu Ala Met Tyr Glu Arg Cys Pro Arg Ala Val
         195                 200                 205            
 Glu Pro Leu Trp Val Glu Gly Ala Gly His Asn Asp Ile Glu Leu Tyr
     210                 215                 220                
 Ala Gln Tyr Leu Glu Arg Leu Lys Gln Phe Ile Ser His Glu Leu Pro
 225                 230                 235                 240
 Asn Ser Xaa Arg Gln Ser Lys
                 245        



      <210> 2129
      <211> 247
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(247)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2129
 Ser Leu His Leu Ser Glu Arg Ala Asp Trp Gln Tyr Ser Gln Arg Ala
   1               5                  10                  15    
 Gly Asp Ala Val Glu Val Phe Phe Ser Arg Thr Ala Arg Asp Asn Arg
              20                  25                  30        
 Leu Gly Cys Met Phe Val Arg Cys Ala Pro Ser Ser Arg Tyr Thr Leu
          35                  40                  45            
 Leu Phe Ser His Gly Asn Ala Val Asp Leu Gly Gln Met Cys Ser Phe
      50                  55                  60                
 Tyr Ile Gly Leu Gly Ser Arg Ile Asn Cys Asn Ile Phe Ser Tyr Asp
  65                  70                  75                  80
 Tyr Ser Gly Tyr Gly Val Ser Ser Gly Lys Pro Ser Glu Lys Asn Leu
                  85                  90                  95    
 Tyr Ala Asp Ile Asp Ala Ala Trp Gln Ala Leu Arg Thr Arg Tyr Gly
             100                 105                 110        
 Val Ser Pro Glu Asn Ile Ile Leu Tyr Gly Gln Ser Ile Gly Thr Val
         115                 120                 125            
 Pro Thr Val Asp Leu Ala Ser Arg Tyr Glu Cys Ala Ala Val Ile Leu
     130                 135                 140                
 His Ser Pro Leu Met Ser Gly Leu Arg Val Ala Phe Pro Asp Thr Arg
 145                 150                 155                 160
 Lys Thr Tyr Cys Phe Asp Ala Phe Pro Ser Ile Asp Lys Ile Ser Lys
                 165                 170                 175    
 Val Thr Ser Pro Val Leu Val Ile His Gly Thr Glu Asp Glu Val Ile
             180                 185                 190        
 Asp Phe Ser His Gly Leu Ala Met Tyr Glu Arg Cys Pro Arg Ala Val
         195                 200                 205            
 Glu Pro Leu Trp Val Glu Gly Ala Gly His Asn Asp Ile Glu Leu Tyr
     210                 215                 220                
 Ala Gln Tyr Leu Glu Arg Leu Lys Gln Phe Ile Ser His Glu Leu Pro
 225                 230                 235                 240
 Asn Ser Xaa Arg Gln Ser Lys
                 245        



      <210> 2130
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 2130
 Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly Arg
   1               5                  10                  15    
 Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu Arg
              20                  25                  30        
 Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asn Asp Gly Lys Leu Gly
          35                  40                  45            
 Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly Pro
      50                  55                  60                
 Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala Ser Gly
  65                  70                  75                  80
 Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly Pro His
                  85                  90                  95    
 Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr Val Cys
             100                 105                 110        
 Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg Met
         115                 120                 125        



      <210> 2131
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 2131
 Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly Arg
   1               5                  10                  15    
 Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu Arg
              20                  25                  30        
 Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asn Asp Gly Lys Leu Gly
          35                  40                  45            
 Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly Pro
      50                  55                  60                
 Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala Ser Gly
  65                  70                  75                  80
 Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly Pro His
                  85                  90                  95    
 Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr Val Cys
             100                 105                 110        
 Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg Met
         115                 120                 125        



      <210> 2132
      <211> 929
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(929)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2132
 Gly Ile Arg Thr Ser Ser Pro Lys Thr Glu Gly Lys His Glu Glu Thr
   1               5                  10                  15    
 Val Asn Lys Glu Ser Asp Met Lys Val Pro Thr Val Ser Leu Lys Val
              20                  25                  30        
 Ser Glu Ser Val Ile Asp Val Lys Thr Thr Met Glu Ser Ile Ser Asn
          35                  40                  45            
 Thr Ser Thr Gln Ser Leu Thr Ala Glu Thr Lys Asp Ile Ala Leu Glu
      50                  55                  60                
 Pro Lys Glu Gln Lys His Glu Asp Arg Gln Ser Asn Thr Pro Ser Pro
  65                  70                  75                  80
 Pro Val Ser Thr Phe Ser Ser Gly Thr Ser Thr Thr Ser Asp Ile Glu
                  85                  90                  95    
 Val Leu Asp His Glu Ser Val Ile Ser Glu Ser Ser Ala Ser Ser Arg
             100                 105                 110        
 Gln Glu Thr Thr Asp Ser Lys Ser Ser Leu His Leu Met Gln Thr Ser
         115                 120                 125            
 Phe Gln Leu Leu Ser Ala Ser Ala Cys Pro Glu Tyr Asn Arg Leu Asp
     130                 135                 140                
 Asp Phe Gln Lys Leu Thr Glu Ser Cys Cys Ser Ser Asp Ala Phe Glu
 145                 150                 155                 160
 Arg Ile Asp Ser Phe Ser Val Gln Ser Leu Asp Ser Arg Ser Val Ser
                 165                 170                 175    
 Glu Ile Asn Ser Asp Asp Glu Leu Ser Gly Lys Gly Tyr Ala Leu Val
             180                 185                 190        
 Pro Ile Ile Val Asn Ser Ser Thr Pro Lys Ser Lys Thr Val Glu Ser
         195                 200                 205            
 Ala Glu Gly Lys Ser Glu Glu Val Asn Glu Thr Leu Val Ile Pro Thr
     210                 215                 220                
 Glu Glu Ala Glu Met Glu Glu Ser Gly Arg Ser Ala Thr Pro Val Asn
 225                 230                 235                 240
 Cys Glu Gln Pro Asp Ile Leu Val Ser Ser Thr Pro Ile Asn Glu Gly
                 245                 250                 255    
 Gln Thr Val Leu Asp Lys Val Ala Glu Gln Cys Glu Pro Ala Glu Ser
             260                 265                 270        
 Gln Pro Glu Ala Leu Ser Glu Lys Glu Asp Val Cys Lys Thr Val Glu
         275                 280                 285            
 Phe Leu Asn Glu Lys Leu Glu Lys Arg Glu Ala Gln Leu Leu Ser Leu
     290                 295                 300                
 Ser Lys Glu Lys Ala Leu Leu Glu Glu Ala Phe Asp Asn Leu Lys Asp
 305                 310                 315                 320
 Glu Met Phe Arg Val Lys Glu Glu Ser Ser Ser Ile Ser Ser Leu Lys
                 325                 330                 335    
 Asp Glu Phe Thr Gln Arg Ile Ala Glu Ala Glu Lys Lys Val Gln Leu
             340                 345                 350        
 Ala Cys Lys Glu Arg Asp Ala Ala Lys Lys Glu Ile Lys Asn Ile Lys
         355                 360                 365            
 Glu Glu Leu Ala Thr Arg Leu Asn Ser Ser Glu Thr Ala Asp Leu Leu
     370                 375                 380                
 Lys Glu Lys Asp Glu Gln Ile Arg Gly Leu Met Glu Glu Gly Glu Lys
 385                 390                 395                 400
 Leu Ser Lys Gln Gln Leu His Asn Ser Asn Ile Ile Lys Lys Leu Arg
                 405                 410                 415    
 Ala Lys Asp Lys Glu Asn Glu Asn Met Val Ala Lys Leu Asn Lys Lys
             420                 425                 430        
 Val Lys Glu Leu Glu Glu Glu Leu Gln His Leu Lys Gln Val Leu Asp
         435                 440                 445            
 Gly Lys Glu Glu Val Glu Lys Gln His Arg Glu Asn Ile Lys Lys Leu
     450                 455                 460                
 Asn Ser Met Val Glu Arg Gln Glu Lys Asp Leu Gly Arg Leu Gln Val
 465                 470                 475                 480
 Asp Met Asp Glu Leu Glu Glu Lys Asn Arg Ser Ile Gln Ala Ala Leu
                 485                 490                 495    
 Asp Ser Ala Tyr Lys Glu Leu Thr Asp Leu His Lys Ala Asn Ala Ala
             500                 505                 510        
 Lys Asp Ser Glu Ala Gln Glu Ala Ala Leu Ser Arg Glu Met Lys Ala
         515                 520                 525            
 Lys Glu Glu Leu Ser Ala Ala Leu Glu Lys Ala Gln Glu Glu Ala Arg
     530                 535                 540                
 Gln Gln Gln Glu Thr Leu Ala Ile Gln Val Gly Asp Leu Arg Leu Ala
 545                 550                 555                 560
 Leu Gln Arg Thr Glu Gln Ala Ala Ala Arg Lys Glu Asp Tyr Leu Arg
                 565                 570                 575    
 His Glu Ile Gly Glu Leu Gln Gln Arg Leu Gln Glu Ala Glu Asn Arg
             580                 585                 590        
 Asn Gln Glu Leu Ser Gln Ser Val Ser Ser Thr Thr Arg Pro Leu Leu
         595                 600                 605            
 Arg Gln Ile Glu Asn Leu Gln Ala Thr Leu Gly Ser Gln Thr Ser Ser
     610                 615                 620                
 Trp Glu Lys Leu Glu Lys Asn Leu Ser Asp Arg Leu Gly Glu Ser Gln
 625                 630                 635                 640
 Thr Leu Leu Ala Ala Ala Val Glu Arg Glu Arg Ala Ala Thr Glu Glu
                 645                 650                 655    
 Leu Leu Ala Asn Lys Ile Gln Met Ser Ser Met Glu Ser Gln Asn Ser
             660                 665                 670        
 Leu Leu Arg Gln Glu Asn Ser Arg Phe Gln Ala Gln Leu Glu Ser Glu
         675                 680                 685            
 Lys Asn Arg Leu Cys Lys Leu Glu Asp Glu Asn Asn Arg Tyr Gln Val
     690                 695                 700                
 Glu Leu Glu Asn Leu Lys Asp Glu Tyr Val Arg Thr Leu Glu Glu Thr
 705                 710                 715                 720
 Arg Lys Glu Lys Thr Leu Leu Asn Ser Gln Leu Glu Met Glu Arg Met
                 725                 730                 735    
 Lys Val Glu Gln Glu Arg Lys Lys Ala Ile Phe Thr Gln Glu Thr Ile
             740                 745                 750        
 Lys Glu Lys Glu Arg Lys Pro Phe Ser Val Ser Ser Thr Pro Thr Met
         755                 760                 765            
 Ser Arg Ser Ser Ser Ile Ser Gly Val Asp Met Ala Gly Leu Gln Thr
     770                 775                 780                
 Ser Phe Leu Ser Gln Asp Glu Ser His Asp His Ser Phe Gly Pro Met
 785                 790                 795                 800
 Pro Ile Ser Ala Lys Trp Lys Gln Ser Leu Xaa Cys Cys Lys Asp Gly
                 805                 810                 815    
 Ser Arg Ile Lys His Ile Glu Asn Leu Gln Ser Gln Leu Lys Leu Arg
             820                 825                 830        
 Glu Gly Glu Ile Thr His Leu Gln Leu Glu Ile Gly Asn Leu Glu Lys
         835                 840                 845            
 Thr Arg Ser Ile Met Ala Glu Glu Leu Val Lys Leu Thr Asn Gln Asn
     850                 855                 860                
 Asp Glu Leu Glu Glu Lys Val Lys Glu Ile Pro Lys Leu Arg Thr Gln
 865                 870                 875                 880
 Leu Arg Asp Leu Asp Gln Arg Tyr Asn Thr Ile Leu Gln Met Tyr Gly
                 885                 890                 895    
 Glu Lys Ala Glu Glu Ala Glu Glu Leu Arg Leu Asp Leu Glu Asp Val
             900                 905                 910        
 Lys Asn Met Tyr Lys Thr Gln Ile Asp Glu Leu Leu Arg Gln Ser Leu
         915                 920                 925            
 Ser
    



      <210> 2133
      <211> 745
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(745)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2133
 Met Ala Ala Ser Ser Ile Arg Asp Glu Arg Thr Arg Thr Tyr Tyr Leu
   1               5                  10                  15    
 Pro Val Val Arg Ala Pro Tyr Thr Cys Asn Phe Arg Pro Ser Ser Ala
              20                  25                  30        
 Ala Val Gly Arg Leu Gly Gly Trp Gly Arg Ala Gln Lys Trp Asn Asn
          35                  40                  45            
 Ser Gly Lys Cys Arg Phe Trp Glu Val Ser Glu Ser Leu Thr Leu Glu
      50                  55                  60                
 Asp Val Ala Val Glu Phe Thr Trp Glu Glu Trp Gln Leu Leu Gly Pro
  65                  70                  75                  80
 Ala Gln Lys Asp Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn
                  85                  90                  95    
 Leu Val Ser Val Gly Tyr Gln Ala Ser Lys Pro Asp Ala Leu Phe Lys
             100                 105                 110        
 Leu Glu Gln Gly Glu Pro Trp Thr Val Glu Asn Glu Ile His Ser Gln
         115                 120                 125            
 Ile Cys Pro Gly Met Tyr Ala Leu Tyr Arg Lys Lys His Asn Gly Tyr
     130                 135                 140                
 Arg Val Lys Tyr Asp Ser Glu Phe Gln Ala Ser Met Val Trp Gly Val
 145                 150                 155                 160
 Ser Trp Asn Ile Ser Pro Ile Asp Glu Gly Leu Leu Tyr Ile Tyr Lys
                 165                 170                 175    
 Arg His Lys Glu Phe Thr Thr Glu Val Asp Lys Gly Cys Glu Thr Asn
             180                 185                 190        
 Ile Gln Met Lys Asp Asp Lys Ile Lys Lys Val Asp Asn His Leu Gln
         195                 200                 205            
 Met His Ser Gln Lys Gln Arg Cys Leu Lys Arg Val Glu Gln Cys His
     210                 215                 220                
 Lys His Asn Ala Phe Gly Asn Ile Ile His Gln Arg Lys Ser Asp Phe
 225                 230                 235                 240
 Pro Leu Arg Gln Asn His Asp Thr Phe Asp Leu His Gly Lys Ile Leu
                 245                 250                 255    
 Lys Ser Asn Leu Ser Leu Val Asn Gln Asn Lys Arg Tyr Glu Ile Lys
             260                 265                 270        
 Asn Ser Val Gly Val Asn Gly Asp Gly Lys Ser Phe Leu His Ala Lys
         275                 280                 285            
 His Glu Gln Phe His Asn Glu Met Asn Phe Pro Glu Gly Gly Asn Ser
     290                 295                 300                
 Val Asn Thr Asn Ser Gln Phe Ile Lys His Gln Arg Thr Gln Asn Ile
 305                 310                 315                 320
 Asp Lys Pro His Val Cys Thr Glu Cys Gly Lys Ala Phe Leu Lys Lys
                 325                 330                 335    
 Ser Arg Leu Ile Tyr His Gln Arg Val His Thr Gly Glu Lys Pro His
             340                 345                 350        
 Gly Cys Ser Ile Cys Gly Lys Ala Phe Ser Arg Lys Ser Gly Leu Thr
         355                 360                 365            
 Glu His Gln Arg Asn His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu
     370                 375                 380                
 Cys Asp Lys Ala Phe Arg Trp Lys Ser Gln Leu Asn Ala His Gln Lys
 385                 390                 395                 400
 Ile His Thr Gly Glu Lys Ser Tyr Ile Cys Ser Asp Cys Gly Lys Gly
                 405                 410                 415    
 Phe Ile Lys Lys Ser Arg Leu Ile Asn His Gln Arg Val His Thr Gly
             420                 425                 430        
 Glu Lys Pro His Gly Cys Ser Leu Cys Gly Lys Ala Phe Ser Lys Arg
         435                 440                 445            
 Ser Arg Leu Thr Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr
     450                 455                 460                
 Glu Cys Thr Glu Cys Asp Lys Ala Phe Arg Trp Lys Ser Gln Leu Asn
 465                 470                 475                 480
 Ala His Gln Lys Ala His Thr Gly Glu Lys Ser Tyr Ile Cys Arg Asp
                 485                 490                 495    
 Cys Gly Lys Gly Phe Ile Gln Lys Gly Asn Leu Ile Val His Gln Arg
             500                 505                 510        
 Ile His Thr Gly Glu Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Gly
         515                 520                 525            
 Phe Ile Gln Lys Gly Asn Leu Leu Ile His Arg Arg Thr His Thr Gly
     530                 535                 540                
 Glu Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Gly Phe Ser Gln Lys
 545                 550                 555                 560
 Thr Cys Leu Ile Ser His Gln Arg Phe His Thr Gly Lys Thr Pro Phe
                 565                 570                 575    
 Val Cys Thr Glu Cys Gly Lys Ser Cys Ser His Lys Ser Gly Leu Ile
             580                 585                 590        
 Asn His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Ser Asp
         595                 600                 605            
 Cys Gly Lys Ala Phe Arg Asp Lys Ser Cys Leu Asn Arg His Arg Arg
     610                 615                 620                
 Thr His Thr Gly Glu Arg Pro Tyr Gly Cys Ser Asp Cys Gly Lys Ala
 625                 630                 635                 640
 Phe Ser His Leu Ser Cys Leu Val Tyr His Lys Gly Met Leu His Ala
                 645                 650                 655    
 Arg Glu Lys Cys Val Gly Cys Ser Gln Ile Gly Lys Ser Leu Leu Arg
             660                 665                 670        
 Glu Ser Xaa Leu Ile Thr Tyr Thr Xaa Ser His Thr Gly Xaa Arg Leu
         675                 680                 685            
 Cys Xaa His Gly Asp Ser Ala Asp Ala Phe Cys Gly Ser Ser Asp Leu
     690                 695                 700                
 Ile Asn Xaa Gln Cys Val Pro Ser Arg Glu Gln Ser Ser His Cys Glu
 705                 710                 715                 720
 Pro Ala Cys Cys Gln Lys Phe Ser Leu Ser Arg Xaa Xaa Asn Cys His
                 725                 730                 735    
 Gly Ile Lys Asn His Tyr Glu Cys Arg
             740                 745



      <210> 2134
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 2134
 Arg Leu Ala Phe Pro Cys Gly Arg Pro Asp Tyr Trp Ala Leu Ala Arg
   1               5                  10                  15    
 Arg Thr Ile Gly Thr Gly Leu Glu Arg Lys Ala Leu Gly Leu Pro Gly
              20                  25                  30        
 Ser Ser Glu Arg Pro Thr Ser Val Ser Ser Tyr Gln Gly Thr Arg Ile
          35                  40                  45            
 Arg Cys Ser Asn Pro Gly Gly Lys Met Arg Pro Leu Thr Glu Glu Glu
      50                  55                  60                
 Thr Arg Val Met Phe Glu Lys Ile Ala Lys Tyr Ile Gly Glu Asn Leu
  65                  70                  75                  80
 Gln Leu Leu Val Asp Arg Pro Asp Gly Thr Tyr Cys Phe Arg Leu His
                  85                  90                  95    
 Asn Asp Arg Val Tyr Tyr Val Ser Glu Lys Ile Met Lys Leu Ala Ala
             100                 105                 110        
 Asn Ile Ser Gly Asp Lys Leu Val Ser Leu Gly Thr Cys Phe Gly Lys
         115                 120                 125            
 Phe Thr Lys Thr His Lys Phe Arg Leu His Val Thr Ala Leu Asp Tyr
     130                 135                 140                
 Leu Ala Pro Tyr Ala Lys Tyr Lys Val Trp Ile Lys Pro Gly Ala Glu
 145                 150                 155                 160
 Gln Ser Phe Leu Tyr Gly Asn His Val Leu Lys Ser Gly Leu Gly Arg
                 165                 170                 175    
 Ile Thr Glu Asn Thr Ser Gln Tyr Gln Gly Val Val Val Tyr Ser Met
             180                 185                 190        
 Ala Asp Ile Pro Leu Gly Phe Gly Val Ala Ala Lys Ser Thr Gln Asp
         195                 200                 205            
 Cys Arg Lys Val Asp Pro Met Ala Ile Val Val Phe His Gln Ala Asp
     210                 215                 220                
 Ile Gly Glu Tyr Val Arg His Glu Glu Thr Leu Thr
 225                 230                 235    



      <210> 2135
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 2135
 Glu Gly Gly Thr Gly Val Arg Ser Leu Ser Phe Tyr Gln His Ile Ile
   1               5                  10                  15    
 Thr Val Gly Thr Gly His Gly Ser Leu Leu Phe Tyr Asp Ile Arg Ala
              20                  25                  30        
 Gln Lys Phe Leu Glu Glu Arg Ala Ser Ser Ser Leu Asp Ser Met Pro
          35                  40                  45            
 Gly Pro Ala Gly Arg Lys Leu Lys Leu Ala Cys Gly Arg Gly Trp Leu
      50                  55                  60                
 Asn Gln Asp Asp Val Trp Val Asn Tyr Phe Gly Gly Met Gly Glu Phe
  65                  70                  75                  80
 Pro Asn Ala Leu Tyr Thr His Cys Tyr Asn Trp Pro Glu Met Lys Leu
                  85                  90                  95    
 Phe Val Ala Gly Gly Pro Leu Pro Ser Gly Leu His Gly Asn Tyr Ala
             100                 105                 110        
 Gly Leu Trp Ser
         115    



      <210> 2136
      <211> 363
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(363)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2136
 Xaa Glu Ser Val Glu Ile Val Ser Glu Val Arg Val Glu Val Gly Glu
   1               5                  10                  15    
 Leu Asn Ile Ile Lys Asp Trp Gly Arg Glu Ser Val Glu Lys Gly Gly
              20                  25                  30        
 Ala Val Ile Ser Met Glu Ala Glu Arg Val Lys Gly Gln Ala Met Ile
          35                  40                  45            
 Ala Thr Gly Gly Val Ile Thr Gly Leu Ala Ala Leu Lys Arg Gln Asp
      50                  55                  60                
 Ser Ala Arg Ser Gln Gln His Val Asn Leu Ser Pro Ser Pro Ala Thr
  65                  70                  75                  80
 Gln Glu Lys Lys Pro Ile Arg Arg Arg Pro Arg Ala Asp Val Val Val
                  85                  90                  95    
 Val Arg Gly Lys Ile Arg Leu Tyr Ser Pro Ser Gly Phe Phe Leu Ile
             100                 105                 110        
 Leu Gly Val Leu Ile Ser Ile Ile Gly Ile Ala Met Ala Val Leu Gly
         115                 120                 125            
 Tyr Trp Pro Gln Lys Glu His Phe Ile Asp Ala Glu Thr Thr Leu Ser
     130                 135                 140                
 Thr Asn Glu Thr Gln Val Ile Arg Asn Glu Gly Gly Val Val Val Arg
 145                 150                 155                 160
 Phe Phe Glu Gln His Leu His Ser Asp Lys Met Lys Met Leu Gly Pro
                 165                 170                 175    
 Phe Thr Met Gly Ile Gly Ile Phe Ile Phe Ile Cys Ala Asn Ala Ile
             180                 185                 190        
 Leu His Glu Asn Arg Asp Lys Glu Thr Lys Ile Ile His Met Arg Asp
         195                 200                 205            
 Ile Tyr Ser Thr Val Ile Asp Ile His Thr Leu Arg Ile Lys Glu Gln
     210                 215                 220                
 Arg Gln Met Asn Gly Met Tyr Thr Gly Leu Met Gly Glu Thr Glu Val
 225                 230                 235                 240
 Lys Gln Asn Gly Ser Ser Cys Ala Ser Arg Leu Ala Ala Asn Thr Ile
                 245                 250                 255    
 Ala Ser Phe Ser Gly Phe Arg Ser Ser Phe Arg Met Asp Ser Ser Val
             260                 265                 270        
 Glu Glu Asp Glu Leu Met Leu Asn Glu Ser Lys Ser Ser Gly His Leu
         275                 280                 285            
 Met Pro Pro Leu Leu Ser Asp Ser Ser Val Ser Val Phe Gly Leu Tyr
     290                 295                 300                
 Pro Pro Pro Ser Lys Thr Thr Asp Asp Lys Thr Ser Gly Ser Lys Lys
 305                 310                 315                 320
 Cys Glu Thr Lys Ser Ile Val Ser Ser Ser Ile Ser Ala Phe Thr Leu
                 325                 330                 335    
 Pro Val Ile Lys Leu Asn Asn Cys Val Ile Asp Glu Pro Ser Ile Asp
             340                 345                 350        
 Asn Ile Thr Glu Asp Ala Asp Asn Leu Lys Xaa
         355                 360            



      <210> 2137
      <211> 414
      <212> PRT
      <213> Homo sapiens


      <400> 2137
 Val Gly Glu Met Thr Leu Ile Trp Arg His Leu Leu Arg Pro Leu Cys
   1               5                  10                  15    
 Leu Val Thr Ser Ala Pro Arg Ile Leu Glu Met His Pro Phe Leu Ser
              20                  25                  30        
 Leu Gly Thr Ser Arg Thr Ser Val Thr Lys Leu Ser Leu His Thr Lys
          35                  40                  45            
 Pro Arg Met Pro Pro Cys Asp Phe Met Pro Glu Arg Tyr Gln Val Ile
      50                  55                  60                
 Phe Leu Val Asn Ser Gly Ser Glu Ala Asn Glu Leu Ala Met Leu Met
  65                  70                  75                  80
 Ala Arg Ala His Ser Asn Asn Ile Asp Ile Ile Ser Phe Arg Gly Ala
                  85                  90                  95    
 Tyr His Gly Cys Ser Pro Tyr Thr Leu Gly Leu Thr Asn Val Gly Ile
             100                 105                 110        
 Tyr Lys Met Glu Leu Pro Gly Gly Thr Gly Cys Gln Pro Thr Met Cys
         115                 120                 125            
 Pro Asp Val Phe Arg Gly Pro Trp Gly Gly Ser His Cys Arg Asp Ser
     130                 135                 140                
 Pro Val Gln Thr Ile Arg Lys Cys Ser Cys Ala Pro Asp Cys Cys Gln
 145                 150                 155                 160
 Ala Lys Asp Gln Tyr Ile Glu Gln Phe Lys Asp Thr Leu Ser Thr Ser
                 165                 170                 175    
 Val Ala Lys Ser Ile Ala Gly Phe Phe Ala Glu Pro Ile Gln Gly Val
             180                 185                 190        
 Asn Gly Val Val Gln Tyr Pro Lys Gly Phe Leu Lys Glu Ala Phe Glu
         195                 200                 205            
 Leu Val Arg Ala Arg Gly Gly Val Cys Ile Ala Asn Glu Val Gln Thr
     210                 215                 220                
 Gly Phe Gly Arg Leu Gly Ser His Phe Trp Gly Phe Gln Thr His Asp
 225                 230                 235                 240
 Val Leu Pro Asp Ile Val Thr Met Ala Lys Gly Ile Gly Asn Gly Phe
                 245                 250                 255    
 Pro Met Ala Ala Val Ile Thr Thr Pro Glu Ile Ala Lys Ser Leu Ala
             260                 265                 270        
 Lys Cys Leu Gln His Phe Asn Thr Phe Gly Gly Asn Pro Met Ala Cys
         275                 280                 285            
 Ala Ile Gly Ser Ala Val Leu Glu Val Ile Lys Glu Glu Asn Leu Gln
     290                 295                 300                
 Glu Asn Ser Gln Glu Val Gly Thr Tyr Met Leu Leu Lys Phe Ala Lys
 305                 310                 315                 320
 Leu Arg Asp Glu Phe Glu Ile Val Gly Asp Val Arg Gly Lys Gly Leu
                 325                 330                 335    
 Met Ile Gly Ile Glu Met Val Gln Asp Lys Ile Ser Cys Arg Pro Leu
             340                 345                 350        
 Pro Arg Glu Glu Val Asn Gln Ile His Glu Asp Cys Lys His Met Gly
         355                 360                 365            
 Leu Leu Val Gly Arg Gly Ser Ile Phe Ser Gln Thr Phe Arg Ile Ala
     370                 375                 380                
 Pro Ser Met Cys Ile Thr Lys Pro Glu Val Asp Phe Ala Val Glu Val
 385                 390                 395                 400
 Phe Arg Ser Ala Leu Thr Gln His Met Glu Arg Arg Ala Lys
                 405                 410                



      <210> 2138
      <211> 414
      <212> PRT
      <213> Homo sapiens


      <400> 2138
 Val Gly Glu Met Thr Leu Ile Trp Arg His Leu Leu Arg Pro Leu Cys
   1               5                  10                  15    
 Leu Val Thr Ser Ala Pro Arg Ile Leu Glu Met His Pro Phe Leu Ser
              20                  25                  30        
 Leu Gly Thr Ser Arg Thr Ser Val Thr Lys Leu Ser Leu His Thr Lys
          35                  40                  45            
 Pro Arg Met Pro Pro Cys Asp Phe Met Pro Glu Arg Tyr Gln Val Ile
      50                  55                  60                
 Phe Leu Val Asn Ser Gly Ser Glu Ala Asn Glu Leu Ala Met Leu Met
  65                  70                  75                  80
 Ala Arg Ala His Ser Asn Asn Ile Asp Ile Ile Ser Phe Arg Gly Ala
                  85                  90                  95    
 Tyr His Gly Cys Ser Pro Tyr Thr Leu Gly Leu Thr Asn Val Gly Ile
             100                 105                 110        
 Tyr Lys Met Glu Leu Pro Gly Gly Thr Gly Cys Gln Pro Thr Met Cys
         115                 120                 125            
 Pro Asp Val Phe Arg Gly Pro Trp Gly Gly Ser His Cys Arg Asp Ser
     130                 135                 140                
 Pro Val Gln Thr Ile Arg Lys Cys Ser Cys Ala Pro Asp Cys Cys Gln
 145                 150                 155                 160
 Ala Lys Asp Gln Tyr Ile Glu Gln Phe Lys Asp Thr Leu Ser Thr Ser
                 165                 170                 175    
 Val Ala Lys Ser Ile Ala Gly Phe Phe Ala Glu Pro Ile Gln Gly Val
             180                 185                 190        
 Asn Gly Val Val Gln Tyr Pro Lys Gly Phe Leu Lys Glu Ala Phe Glu
         195                 200                 205            
 Leu Val Arg Ala Arg Gly Gly Val Cys Ile Ala Asn Glu Val Gln Thr
     210                 215                 220                
 Gly Phe Gly Arg Leu Gly Ser His Phe Trp Gly Phe Gln Thr His Asp
 225                 230                 235                 240
 Val Leu Pro Asp Ile Val Thr Met Ala Lys Gly Ile Gly Asn Gly Phe
                 245                 250                 255    
 Pro Met Ala Ala Val Ile Thr Thr Pro Glu Ile Ala Lys Ser Leu Ala
             260                 265                 270        
 Lys Cys Leu Gln His Phe Asn Thr Phe Gly Gly Asn Pro Met Ala Cys
         275                 280                 285            
 Ala Ile Gly Ser Ala Val Leu Glu Val Ile Lys Glu Glu Asn Leu Gln
     290                 295                 300                
 Glu Asn Ser Gln Glu Val Gly Thr Tyr Met Leu Leu Lys Phe Ala Lys
 305                 310                 315                 320
 Leu Arg Asp Glu Phe Glu Ile Val Gly Asp Val Arg Gly Lys Gly Leu
                 325                 330                 335    
 Met Ile Gly Ile Glu Met Val Gln Asp Lys Ile Ser Cys Arg Pro Leu
             340                 345                 350        
 Pro Arg Glu Glu Val Asn Gln Ile His Glu Asp Cys Lys His Met Gly
         355                 360                 365            
 Leu Leu Val Gly Arg Gly Ser Ile Phe Ser Gln Thr Phe Arg Ile Ala
     370                 375                 380                
 Pro Ser Met Cys Ile Thr Lys Pro Glu Val Asp Phe Ala Val Glu Val
 385                 390                 395                 400
 Phe Arg Ser Ala Leu Thr Gln His Met Glu Arg Arg Ala Lys
                 405                 410                



      <210> 2139
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 2139
 Glu Gly Lys Pro Ala Ser Ala Ile Val Gly Gly Lys Pro Ala Asn Ile
   1               5                  10                  15    
 Leu Glu Phe Pro Trp His Val Gly Ile Met Asn His Gly Ser His Leu
              20                  25                  30        
 Cys Gly Gly Ser Ile Leu Asn Glu Trp Trp Val Leu Ser Ala Ser His
          35                  40                  45            
 Cys Phe Asp Gln Leu Asn Asn Ser Lys Leu Glu Ile Ile His Gly Thr
      50                  55                  60                
 Glu Asp Leu Ser Thr Lys Gly Ile Lys Tyr Gln Lys Val Asp Lys Leu
  65                  70                  75                  80
 Phe Leu His Pro Lys Phe Asp Asp Trp Leu Leu Asp Asn Asp Ile Ala
                  85                  90                  95    
 Leu Leu Leu Leu Lys Ser Pro Leu Asn Leu Ser Val Asn Arg Ile Pro
             100                 105                 110        
 Ile Cys Thr Ser Glu Ile Ser Asp
         115                 120



      <210> 2140
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 2140
 Glu Ile Ala Asn Leu Ile Leu Ala Glu Asn Cys Glu Ala Ala Leu Ala
   1               5                  10                  15    
 Leu His Leu Tyr Arg Gly Gly Arg Leu Leu Gln Gly His Arg Ile Pro
              20                  25                  30        
 Phe Gly Val Ile Phe Gly Gly Thr Asp Val Asn Glu Asp Ala Asn Gln
          35                  40                  45            
 Ala Glu Lys Asn Thr Val Met Gly Arg Val Leu Glu Glu Ala Arg Phe
      50                  55                  60                
 Ala Val Ala Phe Thr Glu Ser Met Lys Glu Met Ala Gln Ala Gln Trp
  65                  70                  75                  80
 Val Asp Pro Val Phe Thr Arg Glu Val Lys Ala Lys Val Lys Arg Ala
                  85                  90                  95    
 Ala Gly Val Arg Leu Ile Gly Glu Met Pro Gln Glu Asp Leu His Ala
             100                 105                 110        
 Val Val Lys Asn Cys Phe Ala Val Val Asn Ser Ser Val Ser Glu Gly
         115                 120                 125            
 Met Ser Ala Ala Ile Leu Glu Ala Met Asp Leu Glu Val Pro Val Leu
     130                 135                 140                
 Ala Arg Asn Ile Pro Gly Asn Ala Ala Val Val Lys His Glu Val Thr
 145                 150                 155                 160
 Gly Leu Leu Phe Ser Asn Pro Gln Glu Phe Val His Leu Ala Lys Arg
                 165                 170                 175    
 Leu Val Ser Asp Pro Ala Leu Glu Lys Glu Ile Val Val Asn Gly Arg
             180                 185                 190        
 Glu Tyr Val Arg Met Tyr His Ser Trp Gln Val Glu Arg Asp Thr Tyr
         195                 200                 205            
 Gln Gln Leu Ile Arg Lys Leu Glu Gly Ser Thr Glu Asp
     210                 215                 220    



      <210> 2141
      <211> 502
      <212> PRT
      <213> Homo sapiens


      <400> 2141
 Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val
   1               5                  10                  15    
 Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro
              20                  25                  30        
 Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu
          35                  40                  45            
 Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile
      50                  55                  60                
 Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu
  65                  70                  75                  80
 Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser
                  85                  90                  95    
 Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr
             100                 105                 110        
 Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val
         115                 120                 125            
 Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala
     130                 135                 140                
 Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro
 145                 150                 155                 160
 Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala
                 165                 170                 175    
 Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu
             180                 185                 190        
 Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met
         195                 200                 205            
 Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu
     210                 215                 220                
 Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr
 225                 230                 235                 240
 Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr
                 245                 250                 255    
 Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro
             260                 265                 270        
 Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly
         275                 280                 285            
 Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val
     290                 295                 300                
 Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys
 305                 310                 315                 320
 Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val
                 325                 330                 335    
 Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr
             340                 345                 350        
 Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp
         355                 360                 365            
 Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr
     370                 375                 380                
 Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val
 385                 390                 395                 400
 Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser
                 405                 410                 415    
 Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser
             420                 425                 430        
 Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe
         435                 440                 445            
 Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro
     450                 455                 460                
 Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu
 465                 470                 475                 480
 His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His
                 485                 490                 495    
 Asp Gly Cys Cys Ser Leu
             500        



      <210> 2142
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 2142
 Pro Asp Pro Cys Leu Asn Gly Gly Ser Cys Val Asp Leu Val Gly Asn
   1               5                  10                  15    
 Tyr Thr Cys Leu Cys Ala Glu Pro Phe Lys Gly Leu Arg Cys Glu Thr
              20                  25                  30        
 Gly Asp His Pro Val Pro Asp Ala Cys Leu Ser Ala Pro Cys His Asn
          35                  40                  45            
 Gly Gly Thr Cys Val Asp Ala Asp Gln Gly Tyr Val Cys Glu Tyr Pro
      50                  55                  60                
 Glu Gly Phe Met Gly Leu Asp Cys Arg Glu Arg Val Pro Asp Asp Cys
  65                  70                  75                  80
 Glu Cys Arg Asn Gly Gly Arg Cys Leu Gly Ala Asn Thr Thr Leu Cys
                  85                  90                  95    
 Gln Cys Pro Leu Gly Phe Phe Gly Leu Leu Cys Glu Phe Glu Ile Thr
             100                 105                 110        
 Ala Met Pro Cys Asn Met Asn Thr Gln Cys Pro Asp Gly Gly Tyr Cys
         115                 120                 125            
 Met Glu His Gly Gly Ser Tyr Leu Cys Gln Cys Pro Leu Gly Phe Phe
     130                 135                 140                
 Gly Leu Leu Cys Glu Phe Glu Ile Thr Ala Met Pro Cys Asn Met Asn
 145                 150                 155                 160
 Thr Gln Cys Pro Asp Gly Gly Tyr Cys Met Glu His Gly Gly Ser Tyr
                 165                 170                 175    
 Leu Cys Val Cys His Thr Asp His Asn Ala Ser His Ser Leu Pro Ser
             180                 185                 190        
 Pro Cys Asp Ser Asp Pro Ser Ser Cys Gln Ala Trp Arg Asn Glu
         195                 200                 205        



      <210> 2143
      <211> 27
      <212> PRT
      <213> Homo sapiens


      <400> 2143
 Pro Ala Met Asn Val Asn Asp Ser Val Thr Lys Gln Lys Phe Asp Asn
   1               5                  10                  15    
 Leu Tyr Cys Cys Arg Glu Ser Ile Leu Asp Gly
              20                  25        



      <210> 2144
      <211> 161
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(161)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2144
 Ile Ala Ser Gln Asn Phe Asp Pro Ala Thr Val Ser Val Ala Thr Ala
   1               5                  10                  15    
 His Lys Gly Ala Glu Pro Ser Arg Gly Thr Ala Trp Gly Pro Val Ala
              20                  25                  30        
 Lys Arg Leu Gln Gln Glu Leu Met Thr Leu Met Met Pro Gly Asp Lys
          35                  40                  45            
 Arg Ile Ser Ala Tyr Pro Glu Ser Leu Ile Lys Trp Thr Pro Ser Met
      50                  55                  60                
 Lys Gln Leu Ala Gln Cys Met Lys Ile Xaa Gly Ile Ser Ser Cys Trp
  65                  70                  75                  80
 Ser Ser Ser Met Thr Thr His Leu Tyr Asp Ala Pro Thr Val Lys Phe
                  85                  90                  95    
 Leu Thr Pro Cys Tyr His Pro Asn Val Asp Thr Gln Gly Asn Ile Cys
             100                 105                 110        
 Leu Asp Ile Leu Lys Glu Lys Trp Ser Ala Pro Tyr Asp Ile Arg Thr
         115                 120                 125            
 Ile Leu Leu Ser Ile Gln Cys Leu Leu Gly Gln Leu Asn Ile Asp Ser
     130                 135                 140                
 Pro Leu Asn Thr His Ala Thr Lys Leu Trp Glu Asn Pro Ile Ala Leu
 145                 150                 155                 160
 Arg
    



      <210> 2145
      <211> 510
      <212> PRT
      <213> Homo sapiens


      <400> 2145
 Ala Pro Tyr Leu Pro Asp Pro Met Lys His Thr Leu Ala Leu Leu Ala
   1               5                  10                  15    
 Pro Leu Leu Gly Leu Gly Leu Gly Leu Ala Leu Ser Gln Leu Ala Ala
              20                  25                  30        
 Gly Ala Thr Asp Cys Lys Phe Leu Gly Pro Ala Glu His Leu Thr Phe
          35                  40                  45            
 Thr Pro Ala Ala Arg Ala Arg Trp Leu Ala Pro Arg Val Arg Ala Pro
      50                  55                  60                
 Gly Leu Leu Asp Ser Leu Tyr Gly Thr Val Arg Arg Phe Leu Ser Val
  65                  70                  75                  80
 Val Gln Leu Asn Pro Phe Pro Ser Glu Leu Val Lys Ala Leu Leu Asn
                  85                  90                  95    
 Glu Leu Ala Ser Val Lys Val Asn Glu Val Val Arg Tyr Glu Ala Gly
             100                 105                 110        
 Tyr Val Val Cys Ala Val Ile Ala Gly Leu Tyr Leu Leu Leu Val Pro
         115                 120                 125            
 Thr Ala Gly Leu Cys Phe Cys Cys Cys Arg Cys His Arg Arg Cys Gly
     130                 135                 140                
 Gly Arg Val Lys Thr Glu His Lys Ala Leu Ala Cys Glu Arg Ala Ala
 145                 150                 155                 160
 Leu Met Val Phe Leu Leu Leu Thr Thr Leu Leu Leu Leu Ile Gly Val
                 165                 170                 175    
 Val Cys Ala Phe Val Thr Asn Gln Arg Thr His Glu Gln Met Gly Pro
             180                 185                 190        
 Ser Ile Glu Ala Met Pro Glu Thr Leu Leu Ser Leu Trp Gly Leu Val
         195                 200                 205            
 Ser Asp Val Pro Gln Gly Val Gly Val Ser Ile Gly Ser Ala Ile His
     210                 215                 220                
 Thr Gln Leu Arg Ser Ser Val Thr Pro Cys Leu Ala Ala Val Gly Ser
 225                 230                 235                 240
 Leu Gly Gln Val Leu Gln Val Ser Val His His Leu Gln Thr Leu Asn
                 245                 250                 255    
 Ala Thr Val Val Glu Leu Gln Ala Gly Gln Gln Asp Leu Glu Pro Ala
             260                 265                 270        
 Ile Arg Glu His Arg Asp Arg Leu Leu Glu Leu Leu Gln Glu Ser Gln
         275                 280                 285            
 Val Pro Ser Val Asp His Val Leu His Gln Leu Lys Gly Val Pro Glu
     290                 295                 300                
 Ala Asn Phe Ser Ser Met Val Gln Glu Glu Asn Ser Thr Phe Asn Ala
 305                 310                 315                 320
 Leu Pro Ala Leu Ala Ala Met Gln Thr Ser Ser Val Val Gln Glu Leu
                 325                 330                 335    
 Lys Lys Ala Val Ala Gln Gln Pro Glu Gly Val Arg Thr Leu Ala Glu
             340                 345                 350        
 Gly Phe Pro Gly Leu Glu Ala Ala Ser Arg Trp Ala Gln Ala Leu Gln
         355                 360                 365            
 Glu Val Glu Glu Ser Ser Arg Pro Tyr Leu Gln Glu Val Gln Arg Tyr
     370                 375                 380                
 Glu Thr Tyr Arg Trp Ile Val Gly Cys Val Leu Cys Ser Val Val Leu
 385                 390                 395                 400
 Phe Val Val Leu Cys Asn Leu Leu Gly Leu Asn Leu Gly Ile Trp Gly
                 405                 410                 415    
 Leu Ser Ala Arg Asp Asp Pro Ser His Pro Glu Ala Lys Gly Glu Ala
             420                 425                 430        
 Gly Ala Arg Phe Leu Met Ala Gly Val Gly Leu Ser Phe Leu Phe Ala
         435                 440                 445            
 Ala Pro Leu Ile Leu Leu Val Phe Ala Thr Phe Leu Val Gly Gly Asn
     450                 455                 460                
 Val Gln Thr Leu Val Cys Gln Ser Trp Glu Asn Gly Glu Leu Phe Glu
 465                 470                 475                 480
 Phe Ala Asp Thr Pro Gly Asn Leu Pro Pro Ser Met Asn Leu Ser Gln
                 485                 490                 495    
 Leu Leu Gly Leu Arg Lys Asn Ile Ser Ile His Gln Ala Tyr
             500                 505                 510



      <210> 2146
      <211> 237
      <212> PRT
      <213> Homo sapiens


      <400> 2146
 Asp Leu Lys Asp Thr Ile Gly Ser Val Thr Lys Thr Pro Ser Gly Leu
   1               5                  10                  15    
 Tyr Ile Ile His Pro Glu Gly Ser Ser Tyr Pro Phe Glu Val Met Cys
              20                  25                  30        
 Asp Met Asp Tyr Arg Gly Gly Gly Trp Thr Val Ile Gln Lys Arg Ile
          35                  40                  45            
 Asp Gly Ile Ile Asp Phe Gln Arg Leu Trp Cys Asp Tyr Leu Asp Gly
      50                  55                  60                
 Phe Gly Asp Leu Leu Gly Glu Phe Trp Leu Gly Leu Lys Lys Ile Phe
  65                  70                  75                  80
 Tyr Ile Val Asn Gln Lys Asn Thr Ser Phe Met Leu Tyr Val Ala Leu
                  85                  90                  95    
 Glu Ser Glu Asp Asp Thr Leu Ala Tyr Ala Ser Tyr Asp Asn Phe Trp
             100                 105                 110        
 Leu Glu Asp Glu Thr Arg Phe Phe Lys Met His Leu Gly Arg Tyr Ser
         115                 120                 125            
 Gly Asn Ala Gly Asp Ala Phe Arg Gly Leu Lys Lys Glu Asp Asn Gln
     130                 135                 140                
 Asn Ala Met Pro Phe Ser Thr Ser Asp Val Asp Asn Asp Gly Cys Arg
 145                 150                 155                 160
 Pro Ala Cys Leu Val Asn Gly Gln Ser Val Lys Ser Cys Ser His Leu
                 165                 170                 175    
 His Asn Lys Thr Gly Trp Trp Phe Asn Glu Cys Gly Leu Ala Asn Leu
             180                 185                 190        
 Asn Gly Ile His His Phe Ser Gly Lys Leu Leu Ala Thr Gly Ile Gln
         195                 200                 205            
 Trp Gly Thr Trp Thr Lys Asn Asn Ser Pro Val Lys Ile Lys Ser Val
     210                 215                 220                
 Ser Met Lys Ile Arg Arg Met Tyr Asn Pro Tyr Phe Lys
 225                 230                 235        



      <210> 2147
      <211> 237
      <212> PRT
      <213> Homo sapiens


      <400> 2147
 Asp Leu Lys Asp Thr Ile Gly Ser Val Thr Lys Thr Pro Ser Gly Leu
   1               5                  10                  15    
 Tyr Ile Ile His Pro Glu Gly Ser Ser Tyr Pro Phe Glu Val Met Cys
              20                  25                  30        
 Asp Met Asp Tyr Arg Gly Gly Gly Trp Thr Val Ile Gln Lys Arg Ile
          35                  40                  45            
 Asp Gly Ile Ile Asp Phe Gln Arg Leu Trp Cys Asp Tyr Leu Asp Gly
      50                  55                  60                
 Phe Gly Asp Leu Leu Gly Glu Phe Trp Leu Gly Leu Lys Lys Ile Phe
  65                  70                  75                  80
 Tyr Ile Val Asn Gln Lys Asn Thr Ser Phe Met Leu Tyr Val Ala Leu
                  85                  90                  95    
 Glu Ser Glu Asp Asp Thr Leu Ala Tyr Ala Ser Tyr Asp Asn Phe Trp
             100                 105                 110        
 Leu Glu Asp Glu Thr Arg Phe Phe Lys Met His Leu Gly Arg Tyr Ser
         115                 120                 125            
 Gly Asn Ala Gly Asp Ala Phe Arg Gly Leu Lys Lys Glu Asp Asn Gln
     130                 135                 140                
 Asn Ala Met Pro Phe Ser Thr Ser Asp Val Asp Asn Asp Gly Cys Arg
 145                 150                 155                 160
 Pro Ala Cys Leu Val Asn Gly Gln Ser Val Lys Ser Cys Ser His Leu
                 165                 170                 175    
 His Asn Lys Thr Gly Trp Trp Phe Asn Glu Cys Gly Leu Ala Asn Leu
             180                 185                 190        
 Asn Gly Ile His His Phe Ser Gly Lys Leu Leu Ala Thr Gly Ile Gln
         195                 200                 205            
 Trp Gly Thr Trp Thr Lys Asn Asn Ser Pro Val Lys Ile Lys Ser Val
     210                 215                 220                
 Ser Met Lys Ile Arg Arg Met Tyr Asn Pro Tyr Phe Lys
 225                 230                 235        



      <210> 2148
      <211> 237
      <212> PRT
      <213> Homo sapiens


      <400> 2148
 Asp Leu Lys Asp Thr Ile Gly Ser Val Thr Lys Thr Pro Ser Gly Leu
   1               5                  10                  15    
 Tyr Ile Ile His Pro Glu Gly Ser Ser Tyr Pro Phe Glu Val Met Cys
              20                  25                  30        
 Asp Met Asp Tyr Arg Gly Gly Gly Trp Thr Val Ile Gln Lys Arg Ile
          35                  40                  45            
 Asp Gly Ile Ile Asp Phe Gln Arg Leu Trp Cys Asp Tyr Leu Asp Gly
      50                  55                  60                
 Phe Gly Asp Leu Leu Gly Glu Phe Trp Leu Gly Leu Lys Lys Ile Phe
  65                  70                  75                  80
 Tyr Ile Val Asn Gln Lys Asn Thr Ser Phe Met Leu Tyr Val Ala Leu
                  85                  90                  95    
 Glu Ser Glu Asp Asp Thr Leu Ala Tyr Ala Ser Tyr Asp Asn Phe Trp
             100                 105                 110        
 Leu Glu Asp Glu Thr Arg Phe Phe Lys Met His Leu Gly Arg Tyr Ser
         115                 120                 125            
 Gly Asn Ala Gly Asp Ala Phe Arg Gly Leu Lys Lys Glu Asp Asn Gln
     130                 135                 140                
 Asn Ala Met Pro Phe Ser Thr Ser Asp Val Asp Asn Asp Gly Cys Arg
 145                 150                 155                 160
 Pro Ala Cys Leu Val Asn Gly Gln Ser Val Lys Ser Cys Ser His Leu
                 165                 170                 175    
 His Asn Lys Thr Gly Trp Trp Phe Asn Glu Cys Gly Leu Ala Asn Leu
             180                 185                 190        
 Asn Gly Ile His His Phe Ser Gly Lys Leu Leu Ala Thr Gly Ile Gln
         195                 200                 205            
 Trp Gly Thr Trp Thr Lys Asn Asn Ser Pro Val Lys Ile Lys Ser Val
     210                 215                 220                
 Ser Met Lys Ile Arg Arg Met Tyr Asn Pro Tyr Phe Lys
 225                 230                 235        



      <210> 2149
      <211> 56
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(56)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2149
 Asp Arg Leu Glu Ser Leu Leu Glu Met His Ile Pro Gly Val Tyr Pro
   1               5                  10                  15    
 Asn Gln Trp Asn Thr Asn Phe Tyr Leu Phe Ile Tyr Phe Glu Ala Glu
              20                  25                  30        
 Ser His Ser Val Ala Gln Thr Gly Leu Gln Xaa Arg His Leu Gly Ser
          35                  40                  45            
 Leu Gln Leu Pro Pro Pro Gln Val
      50                  55    



      <210> 2150
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 2150
 Met Ser Arg Asn Leu Arg Thr Ala Leu Ile Phe Gly Gly Phe Ile Ser
   1               5                  10                  15    
 Leu Ile Gly Ala Ala Phe Tyr Pro Ile Tyr Phe Arg Pro Leu Met Arg
              20                  25                  30        
 Leu Glu Glu Tyr Lys Lys Glu Gln Ala Ile Asn Arg Ala Gly Ile Val
          35                  40                  45            
 Gln Glu Asp Val Gln Pro Pro Gly Leu Lys Val Trp Ser Asp Pro Phe
      50                  55                  60                
 Gly Arg Lys
  65        



      <210> 2151
      <211> 424
      <212> PRT
      <213> Homo sapiens


      <400> 2151
 Met Ser Leu Thr Ile Trp Thr Val Cys Gly Val Leu Ser Leu Phe Gly
   1               5                  10                  15    
 Ala Leu Ser Tyr Ala Glu Leu Gly Thr Thr Ile Lys Lys Ser Gly Gly
              20                  25                  30        
 His Tyr Thr Tyr Ile Leu Glu Val Phe Gly Pro Leu Pro Ala Phe Val
          35                  40                  45            
 Arg Val Trp Val Glu Leu Leu Ile Ile Arg Pro Ala Ala Thr Ala Val
      50                  55                  60                
 Ile Ser Leu Ala Phe Gly Arg Tyr Ile Leu Glu Pro Phe Phe Ile Gln
  65                  70                  75                  80
 Cys Glu Ile Pro Glu Leu Ala Ile Lys Leu Ile Thr Ala Val Gly Ile
                  85                  90                  95    
 Thr Val Val Met Val Leu Asn Ser Met Ser Val Ser Trp Ser Ala Arg
             100                 105                 110        
 Ile Gln Ile Phe Leu Thr Phe Cys Lys Leu Thr Ala Ile Leu Ile Ile
         115                 120                 125            
 Ile Val Pro Gly Val Met Gln Leu Ile Lys Gly Gln Thr Gln Asn Phe
     130                 135                 140                
 Lys Asp Ala Phe Ser Gly Arg Asp Ser Ser Ile Thr Arg Leu Pro Leu
 145                 150                 155                 160
 Ala Phe Tyr Tyr Gly Met Tyr Ala Tyr Ala Gly Trp Phe Tyr Leu Asn
                 165                 170                 175    
 Phe Val Thr Glu Glu Val Glu Asn Pro Glu Lys Thr Ile Pro Leu Ala
             180                 185                 190        
 Ile Cys Ile Ser Met Ala Ile Val Thr Ile Gly Tyr Val Leu Thr Asn
         195                 200                 205            
 Val Ala Tyr Phe Thr Thr Ile Asn Ala Glu Glu Leu Leu Leu Ser Asn
     210                 215                 220                
 Ala Val Ala Val Thr Phe Ser Glu Arg Leu Leu Gly Asn Phe Ser Leu
 225                 230                 235                 240
 Ala Val Pro Ile Phe Val Ala Leu Ser Cys Phe Gly Ser Met Asn Gly
                 245                 250                 255    
 Gly Val Phe Ala Val Ser Arg Leu Phe Tyr Val Ala Ser Arg Glu Gly
             260                 265                 270        
 His Leu Pro Glu Ile Leu Ser Met Ile His Val Arg Lys His Thr Pro
         275                 280                 285            
 Leu Pro Ala Val Ile Val Leu His Pro Leu Thr Met Ile Met Leu Phe
     290                 295                 300                
 Ser Gly Asp Leu Asp Ser Leu Leu Asn Phe Leu Ser Phe Ala Arg Trp
 305                 310                 315                 320
 Leu Phe Ile Gly Leu Ala Val Ala Gly Leu Ile Tyr Leu Arg Tyr Lys
                 325                 330                 335    
 Cys Pro Asp Met His Arg Pro Phe Lys Val Pro Leu Phe Ile Pro Ala
             340                 345                 350        
 Leu Phe Ser Phe Thr Cys Leu Phe Met Val Ala Leu Ser Leu Tyr Ser
         355                 360                 365            
 Asp Pro Phe Ser Thr Gly Ile Gly Phe Val Ile Thr Leu Thr Gly Val
     370                 375                 380                
 Pro Ala Tyr Tyr Leu Phe Ile Ile Trp Asp Lys Lys Pro Arg Trp Phe
 385                 390                 395                 400
 Arg Ile Met Ser Glu Lys Ile Thr Arg Thr Leu Gln Ile Ile Leu Glu
                 405                 410                 415    
 Val Val Pro Glu Glu Asp Lys Leu
             420                



      <210> 2152
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 2152
 Lys Asn Leu Phe Tyr Ser Leu Ser Leu Ile Cys Ser Ser Tyr Pro Ser
   1               5                  10                  15    
 Ile Leu Asp His Ile Val His Ile Ile Glu Leu Ile Gly Arg Ile Pro
              20                  25                  30        
 Arg Arg Phe Ser Leu Ser Gly Lys Tyr Ser Gln Asp Phe Phe Ser His
          35                  40                  45            
 Arg Gly Ser Ile Val Met
      50                



      <210> 2153
      <211> 831
      <212> PRT
      <213> Homo sapiens


      <400> 2153
 Met Thr Leu Ala Leu Ala Tyr Leu Leu Ala Leu Pro Gln Val Leu Asp
   1               5                  10                  15    
 Ala Asn Arg Cys Phe Glu Lys Gln Ser Pro Ser Ala Leu Ser Leu Gln
              20                  25                  30        
 Leu Ala Ala Tyr Tyr Tyr Ser Leu Gln Ile Tyr Ala Arg Leu Ala Pro
          35                  40                  45            
 Cys Phe Arg Asp Lys Cys His Pro Leu Tyr Arg Ala Asp Pro Lys Glu
      50                  55                  60                
 Leu Ile Lys Met Val Thr Arg His Val Thr Arg His Glu His Glu Ala
  65                  70                  75                  80
 Trp Pro Glu Asp Leu Ile Ser Leu Thr Lys Gln Leu His Cys Tyr Asn
                  85                  90                  95    
 Glu Arg Leu Leu Asp Phe Thr Gln Ala Gln Ile Leu Gln Gly Leu Arg
             100                 105                 110        
 Lys Gly Val Asp Val Gln Arg Phe Thr Ala Asp Asp Gln Tyr Lys Arg
         115                 120                 125            
 Glu Thr Ile Leu Gly Leu Ala Glu Thr Leu Glu Glu Ser Val Tyr Ser
     130                 135                 140                
 Ile Ala Ile Ser Leu Ala Gln Arg Tyr Ser Val Ser Arg Trp Glu Val
 145                 150                 155                 160
 Phe Met Thr His Leu Glu Phe Leu Phe Thr Asp Ser Gly Leu Ser Thr
                 165                 170                 175    
 Leu Glu Ile Glu Asn Arg Ala Gln Asp Leu His Leu Phe Glu Thr Leu
             180                 185                 190        
 Lys Thr Asp Pro Glu Ala Phe His Gln His Met Val Lys Tyr Ile Tyr
         195                 200                 205            
 Pro Thr Ile Gly Gly Phe Asp His Glu Arg Leu Gln Tyr Tyr Phe Thr
     210                 215                 220                
 Leu Leu Glu Asn Cys Gly Cys Ala Asp Leu Gly Asn Cys Ala Ile Lys
 225                 230                 235                 240
 Pro Glu Thr His Ile Arg Leu Leu Lys Lys Phe Lys Val Val Ala Ser
                 245                 250                 255    
 Gly Leu Asn Tyr Lys Lys Leu Thr Asp Glu Asn Met Ser Pro Leu Glu
             260                 265                 270        
 Ala Leu Glu Pro Val Leu Ser Ser Gln Asn Ile Leu Ser Ile Ser Lys
         275                 280                 285            
 Leu Val Pro Lys Ile Pro Glu Lys Asp Gly Gln Met Leu Ser Pro Ser
     290                 295                 300                
 Ser Leu Tyr Thr Ile Trp Leu Gln Lys Leu Phe Trp Thr Gly Asp Pro
 305                 310                 315                 320
 His Leu Ile Lys Gln Val Pro Gly Ser Ser Pro Glu Trp Leu His Ala
                 325                 330                 335    
 Tyr Asp Val Cys Met Lys Tyr Phe Asp Arg Leu His Pro Gly Asp Leu
             340                 345                 350        
 Ile Thr Val Val Asp Ala Val Thr Phe Ser Pro Lys Ala Val Thr Lys
         355                 360                 365            
 Leu Ser Val Glu Ala Arg Lys Glu Met Thr Arg Lys Ala Ile Lys Thr
     370                 375                 380                
 Val Lys His Phe Ile Glu Lys Pro Arg Lys Arg Asn Ser Glu Asp Glu
 385                 390                 395                 400
 Ala Gln Glu Ala Lys Asp Ser Lys Val Thr Tyr Ala Asp Thr Leu Asn
                 405                 410                 415    
 His Leu Glu Lys Ser Leu Ala His Leu Glu Thr Leu Ser His Ser Phe
             420                 425                 430        
 Ile Leu Ser Leu Lys Asn Ser Glu Gln Glu Thr Leu Gln Lys Tyr Ser
         435                 440                 445            
 His Leu Tyr Asp Leu Ser Arg Ser Glu Lys Glu Lys Leu His Asp Glu
     450                 455                 460                
 Ala Val Ala Ile Cys Leu Asp Gly Gln Pro Leu Ala Met Ile Gln Gln
 465                 470                 475                 480
 Leu Leu Glu Val Ala Val Gly Pro Leu Asp Ile Ser Pro Lys Asp Ile
                 485                 490                 495    
 Val Gln Ser Ala Ile Met Lys Ile Ile Ser Ala Leu Ser Gly Gly Ser
             500                 505                 510        
 Ala Asp Leu Gly Gly Pro Arg Asp Pro Leu Lys Val Leu Glu Gly Val
         515                 520                 525            
 Val Ala Ala Val His Ala Ser Val Asp Lys Gly Glu Glu Leu Val Ser
     530                 535                 540                
 Pro Glu Asp Leu Leu Glu Trp Leu Arg Pro Phe Cys Ala Asp Asp Ala
 545                 550                 555                 560
 Trp Pro Val Arg Pro Arg Ile His Val Leu Gln Ile Leu Gly Gln Ser
                 565                 570                 575    
 Phe His Leu Thr Glu Glu Asp Ser Lys Leu Leu Val Phe Phe Arg Thr
             580                 585                 590        
 Glu Ala Ile Leu Lys Ala Ser Trp Pro Gln Arg Gln Val Asp Ile Ala
         595                 600                 605            
 Asp Ile Glu Asn Glu Glu Asn Arg Tyr Cys Leu Phe Met Glu Leu Leu
     610                 615                 620                
 Glu Ser Ser His His Glu Ala Glu Phe Gln His Leu Val Leu Leu Leu
 625                 630                 635                 640
 Gln Ala Trp Pro Pro Met Lys Ser Glu Tyr Val Ile Thr Asn Asn Pro
                 645                 650                 655    
 Trp Val Arg Leu Ala Thr Val Met Leu Thr Arg Cys Thr Met Glu Asn
             660                 665                 670        
 Lys Glu Gly Leu Gly Asn Glu Val Leu Lys Met Cys Arg Ser Leu Tyr
         675                 680                 685            
 Asn Thr Lys Gln Met Leu Pro Ala Glu Gly Val Lys Glu Leu Cys Leu
     690                 695                 700                
 Leu Leu Leu Asn Gln Ser Leu Leu Leu Pro Ser Leu Lys Leu Leu Leu
 705                 710                 715                 720
 Glu Ser Arg Asp Glu His Leu His Glu Met Ala Leu Glu Gln Ile Thr
                 725                 730                 735    
 Ala Val Thr Thr Val Asn Asp Ser Asn Cys Asp Gln Glu Leu Leu Ser
             740                 745                 750        
 Leu Leu Leu Asp Ala Lys Leu Leu Val Lys Cys Val Ser Thr Pro Phe
         755                 760                 765            
 Tyr Pro Arg Ile Val Asp His Leu Leu Ala Ser Leu Gln Gln Gly Arg
     770                 775                 780                
 Trp Asp Ala Glu Glu Leu Gly Arg His Leu Arg Glu Ala Gly His Glu
 785                 790                 795                 800
 Ala Glu Ala Gly Ser Leu Leu Leu Ala Val Arg Gly Thr His Gln Ala
                 805                 810                 815    
 Phe Arg Thr Phe Ser Thr Ala Leu Arg Ala Ala Gln His Trp Val
             820                 825                 830    



      <210> 2154
      <211> 831
      <212> PRT
      <213> Homo sapiens


      <400> 2154
 Met Thr Leu Ala Leu Ala Tyr Leu Leu Ala Leu Pro Gln Val Leu Asp
   1               5                  10                  15    
 Ala Asn Arg Cys Phe Glu Lys Gln Ser Pro Ser Ala Leu Ser Leu Gln
              20                  25                  30        
 Leu Ala Ala Tyr Tyr Tyr Ser Leu Gln Ile Tyr Ala Arg Leu Ala Pro
          35                  40                  45            
 Cys Phe Arg Asp Lys Cys His Pro Leu Tyr Arg Ala Asp Pro Lys Glu
      50                  55                  60                
 Leu Ile Lys Met Val Thr Arg His Val Thr Arg His Glu His Glu Ala
  65                  70                  75                  80
 Trp Pro Glu Asp Leu Ile Ser Leu Thr Lys Gln Leu His Cys Tyr Asn
                  85                  90                  95    
 Glu Arg Leu Leu Asp Phe Thr Gln Ala Gln Ile Leu Gln Gly Leu Arg
             100                 105                 110        
 Lys Gly Val Asp Val Gln Arg Phe Thr Ala Asp Asp Gln Tyr Lys Arg
         115                 120                 125            
 Glu Thr Ile Leu Gly Leu Ala Glu Thr Leu Glu Glu Ser Val Tyr Ser
     130                 135                 140                
 Ile Ala Ile Ser Leu Ala Gln Arg Tyr Ser Val Ser Arg Trp Glu Val
 145                 150                 155                 160
 Phe Met Thr His Leu Glu Phe Leu Phe Thr Asp Ser Gly Leu Ser Thr
                 165                 170                 175    
 Leu Glu Ile Glu Asn Arg Ala Gln Asp Leu His Leu Phe Glu Thr Leu
             180                 185                 190        
 Lys Thr Asp Pro Glu Ala Phe His Gln His Met Val Lys Tyr Ile Tyr
         195                 200                 205            
 Pro Thr Ile Gly Gly Phe Asp His Glu Arg Leu Gln Tyr Tyr Phe Thr
     210                 215                 220                
 Leu Leu Glu Asn Cys Gly Cys Ala Asp Leu Gly Asn Cys Ala Ile Lys
 225                 230                 235                 240
 Pro Glu Thr His Ile Arg Leu Leu Lys Lys Phe Lys Val Val Ala Ser
                 245                 250                 255    
 Gly Leu Asn Tyr Lys Lys Leu Thr Asp Glu Asn Met Ser Pro Leu Glu
             260                 265                 270        
 Ala Leu Glu Pro Val Leu Ser Ser Gln Asn Ile Leu Ser Ile Ser Lys
         275                 280                 285            
 Leu Val Pro Lys Ile Pro Glu Lys Asp Gly Gln Met Leu Ser Pro Ser
     290                 295                 300                
 Ser Leu Tyr Thr Ile Trp Leu Gln Lys Leu Phe Trp Thr Gly Asp Pro
 305                 310                 315                 320
 His Leu Ile Lys Gln Val Pro Gly Ser Ser Pro Glu Trp Leu His Ala
                 325                 330                 335    
 Tyr Asp Val Cys Met Lys Tyr Phe Asp Arg Leu His Pro Gly Asp Leu
             340                 345                 350        
 Ile Thr Val Val Asp Ala Val Thr Phe Ser Pro Lys Ala Val Thr Lys
         355                 360                 365            
 Leu Ser Val Glu Ala Arg Lys Glu Met Thr Arg Lys Ala Ile Lys Thr
     370                 375                 380                
 Val Lys His Phe Ile Glu Lys Pro Arg Lys Arg Asn Ser Glu Asp Glu
 385                 390                 395                 400
 Ala Gln Glu Ala Lys Asp Ser Lys Val Thr Tyr Ala Asp Thr Leu Asn
                 405                 410                 415    
 His Leu Glu Lys Ser Leu Ala His Leu Glu Thr Leu Ser His Ser Phe
             420                 425                 430        
 Ile Leu Ser Leu Lys Asn Ser Glu Gln Glu Thr Leu Gln Lys Tyr Ser
         435                 440                 445            
 His Leu Tyr Asp Leu Ser Arg Ser Glu Lys Glu Lys Leu His Asp Glu
     450                 455                 460                
 Ala Val Ala Ile Cys Leu Asp Gly Gln Pro Leu Ala Met Ile Gln Gln
 465                 470                 475                 480
 Leu Leu Glu Val Ala Val Gly Pro Leu Asp Ile Ser Pro Lys Asp Ile
                 485                 490                 495    
 Val Gln Ser Ala Ile Met Lys Ile Ile Ser Ala Leu Ser Gly Gly Ser
             500                 505                 510        
 Ala Asp Leu Gly Gly Pro Arg Asp Pro Leu Lys Val Leu Glu Gly Val
         515                 520                 525            
 Val Ala Ala Val His Ala Ser Val Asp Lys Gly Glu Glu Leu Val Ser
     530                 535                 540                
 Pro Glu Asp Leu Leu Glu Trp Leu Arg Pro Phe Cys Ala Asp Asp Ala
 545                 550                 555                 560
 Trp Pro Val Arg Pro Arg Ile His Val Leu Gln Ile Leu Gly Gln Ser
                 565                 570                 575    
 Phe His Leu Thr Glu Glu Asp Ser Lys Leu Leu Val Phe Phe Arg Thr
             580                 585                 590        
 Glu Ala Ile Leu Lys Ala Ser Trp Pro Gln Arg Gln Val Asp Ile Ala
         595                 600                 605            
 Asp Ile Glu Asn Glu Glu Asn Arg Tyr Cys Leu Phe Met Glu Leu Leu
     610                 615                 620                
 Glu Ser Ser His His Glu Ala Glu Phe Gln His Leu Val Leu Leu Leu
 625                 630                 635                 640
 Gln Ala Trp Pro Pro Met Lys Ser Glu Tyr Val Ile Thr Asn Asn Pro
                 645                 650                 655    
 Trp Val Arg Leu Ala Thr Val Met Leu Thr Arg Cys Thr Met Glu Asn
             660                 665                 670        
 Lys Glu Gly Leu Gly Asn Glu Val Leu Lys Met Cys Arg Ser Leu Tyr
         675                 680                 685            
 Asn Thr Lys Gln Met Leu Pro Ala Glu Gly Val Lys Glu Leu Cys Leu
     690                 695                 700                
 Leu Leu Leu Asn Gln Ser Leu Leu Leu Pro Ser Leu Lys Leu Leu Leu
 705                 710                 715                 720
 Glu Ser Arg Asp Glu His Leu His Glu Met Ala Leu Glu Gln Ile Thr
                 725                 730                 735    
 Ala Val Thr Thr Val Asn Asp Ser Asn Cys Asp Gln Glu Leu Leu Ser
             740                 745                 750        
 Leu Leu Leu Asp Ala Lys Leu Leu Val Lys Cys Val Ser Thr Pro Phe
         755                 760                 765            
 Tyr Pro Arg Ile Val Asp His Leu Leu Ala Ser Leu Gln Gln Gly Arg
     770                 775                 780                
 Trp Asp Ala Glu Glu Leu Gly Arg His Leu Arg Glu Ala Gly His Glu
 785                 790                 795                 800
 Ala Glu Ala Gly Ser Leu Leu Leu Ala Val Arg Gly Thr His Gln Ala
                 805                 810                 815    
 Phe Arg Thr Phe Ser Thr Ala Leu Arg Ala Ala Gln His Trp Val
             820                 825                 830    



      <210> 2155
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 2155
 Gln Glu Leu Glu Arg Ser Met Ala Gln Arg Cys Val Cys Val Leu Ala
   1               5                  10                  15    
 Leu Val Ala Met Leu Leu Leu Val Phe Pro Thr Val Ser Arg Ser Met
              20                  25                  30        
 Gly Pro Arg Ser Gly Glu His Gln Arg Ala Ser Arg Ile Pro Ser Gln
          35                  40                  45            
 Phe Ser Lys Glu Glu Arg Val Ala Met Lys Glu Ala Leu Lys Val Phe
      50                  55                  60                
 Pro Thr Val Val Ser Thr Ser Phe Ile Gln His Glu Val Val Glu Glu
  65                  70                  75                  80
 Tyr Ser His Leu Phe Thr Ile Gln Gly Ser Asp Pro Ser Leu Gln Pro
                  85                  90                  95    
 Tyr Leu Leu Met Ala His Phe Asp Val Val Pro Ala Pro Glu Glu Gly
             100                 105                 110        
 Trp Glu Val Pro Pro Phe Ser Gly
         115                 120



      <210> 2156
      <211> 366
      <212> PRT
      <213> Homo sapiens


      <400> 2156
 Met Ala Leu Arg Phe Leu Leu Gly Phe Leu Leu Ala Gly Val Asp Leu
   1               5                  10                  15    
 Gly Val Tyr Leu Met Arg Leu Glu Leu Cys Asp Pro Thr Gln Arg Leu
              20                  25                  30        
 Arg Val Ala Leu Ala Gly Glu Leu Val Gly Val Gly Gly His Phe Leu
          35                  40                  45            
 Phe Leu Gly Leu Ala Leu Val Ser Lys Asp Trp Arg Phe Leu Gln Arg
      50                  55                  60                
 Met Ile Thr Ala Pro Cys Ile Leu Phe Leu Phe Tyr Gly Trp Pro Gly
  65                  70                  75                  80
 Leu Phe Leu Glu Ser Ala Arg Trp Leu Ile Val Lys Arg Gln Ile Glu
                  85                  90                  95    
 Glu Ala Gln Ser Val Leu Arg Ile Leu Ala Glu Arg Asn Arg Pro His
             100                 105                 110        
 Gly Gln Met Leu Gly Glu Glu Ala Gln Glu Ala Leu Gln Asp Leu Glu
         115                 120                 125            
 Asn Thr Cys Pro Leu Pro Ala Thr Ser Ser Phe Ser Phe Ala Ser Leu
     130                 135                 140                
 Leu Asn Tyr Arg Asn Ile Trp Lys Asn Leu Leu Ile Leu Gly Phe Thr
 145                 150                 155                 160
 Asn Phe Ile Ala His Ala Ile Arg His Cys Tyr Gln Pro Val Gly Gly
                 165                 170                 175    
 Gly Gly Ser Pro Ser Asp Phe Tyr Leu Cys Ser Leu Leu Ala Ser Gly
             180                 185                 190        
 Thr Ala Ala Leu Ala Cys Val Phe Leu Gly Val Thr Val Asp Arg Phe
         195                 200                 205            
 Gly Arg Arg Gly Ile Leu Leu Leu Ser Met Thr Leu Thr Gly Ile Ala
     210                 215                 220                
 Ser Leu Val Leu Leu Gly Leu Trp Asp Tyr Leu Asn Glu Ala Ala Ile
 225                 230                 235                 240
 Thr Thr Phe Ser Val Leu Gly Leu Phe Ser Ser Gln Ala Ala Ala Ile
                 245                 250                 255    
 Leu Ser Thr Leu Leu Ala Ala Glu Val Ile Pro Thr Thr Val Arg Gly
             260                 265                 270        
 Arg Gly Leu Gly Leu Ile Met Ala Leu Gly Ala Leu Gly Gly Leu Ser
         275                 280                 285            
 Gly Pro Ala Gln Arg Leu His Met Gly His Gly Ala Phe Leu Gln His
     290                 295                 300                
 Val Val Leu Ala Ala Cys Ala Leu Leu Cys Ile Leu Ser Ile Met Leu
 305                 310                 315                 320
 Leu Pro Glu Thr Lys Arg Lys Leu Leu Pro Glu Val Leu Arg Asp Gly
                 325                 330                 335    
 Glu Leu Cys Arg Arg Pro Ser Leu Leu Arg Gln Pro Pro Pro Thr Arg
             340                 345                 350        
 Cys Asp His Val Pro Leu Leu Ala Thr Pro Asn Pro Ala Leu
         355                 360                 365    



      <210> 2157
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 2157
 Met Tyr Ala Leu Leu Gly Val Phe Cys Leu Ala Ile Leu Val Phe Leu
   1               5                  10                  15    
 Ile Asn Cys Ala Thr Phe Ala Leu Lys Tyr Arg His Lys Gln Val Pro
              20                  25                  30        
 Leu Glu Gly Gln Ala Ser Met Thr His Ser His Asp Trp Val Trp Leu
          35                  40                  45            
 Gly Asn Glu Ala Glu Leu Leu Glu Ser Met Gly Asp Ala Pro Pro Pro
      50                  55                  60                
 Gln Asp Glu His Thr Thr Ile Ile Asp Arg Gly Pro Gly Ala Cys Glu
  65                  70                  75                  80
 Glu Ser Asn His Leu Leu Leu Asn Gly Gly Ser His Lys His Val Gln
                  85                  90                  95    
 Ser Gln Ile His Arg Ser Ala Asp Ser
             100                 105



      <210> 2158
      <211> 349
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(349)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2158
 Leu Leu Arg Ala Arg Ser Pro Gln Gly Ser Glu Arg Ala Gly Val Gly
   1               5                  10                  15    
 Gly Ala Tyr Met Leu Ser Lys Gly Trp Trp Lys Glu Gly Arg His Gly
              20                  25                  30        
 Gly His Arg Arg Pro Arg Gly Trp Gly Ala Ala Gly Arg Arg Gln Ser
          35                  40                  45            
 Val Pro Gly Gly Pro Ala Ala Pro Pro Cys Thr Leu Tyr Ser Val Gly
      50                  55                  60                
 Ala Asp Gly Arg Gly Gln Gly His Gln Ser Arg Gly Cys Arg Pro Pro
  65                  70                  75                  80
 Gly Pro Pro Ser Ala Ser Ser Ala Pro Cys Leu Ala Trp Gly Ala Ala
                  85                  90                  95    
 Gly Arg Ala Arg Arg Glu Gly Arg Ser Gly Arg Cys Arg Thr Glu Phe
             100                 105                 110        
 Ser Pro Gly Cys Thr Arg Arg Xaa Ala Leu Thr Cys Gly Ala Gly Pro
         115                 120                 125            
 Cys Arg Arg Xaa Ser Arg Xaa Arg Gly Thr Arg Arg Cys Leu Arg Pro
     130                 135                 140                
 Trp Ala Ser Pro Gly Thr Gly Ala Ala Cys Gly Arg Cys Cys Cys Pro
 145                 150                 155                 160
 Pro Pro Xaa Pro His Leu Phe Trp Leu Pro Pro Ser Leu Arg Leu Pro
                 165                 170                 175    
 Ala Glu Met Leu Leu Ala Gly Ser Arg Pro Thr Pro Ala Cys Arg Ser
             180                 185                 190        
 Ser Pro Gly Gly Ser Val His Thr Thr Thr Gly Ser Pro Ala Ser Arg
         195                 200                 205            
 Arg Gly Ser Arg Cys Arg Gly Arg Ser Arg Pro Ser Pro Arg Pro Arg
     210                 215                 220                
 Pro Ser Val Leu Ser Cys His Gly Val Ser Leu Xaa Thr Gly Arg Gly
 225                 230                 235                 240
 Arg Arg Arg Gly Cys Pro Arg Ala Arg Gly Arg Arg Ala Gly Val Ala
                 245                 250                 255    
 Pro Pro Ser Cys Arg Lys Ser Ala Arg Cys Gly Gly Arg Pro Ala Leu
             260                 265                 270        
 Arg Arg Ala Gly Pro Pro Ser Cys Ala Leu Gly Pro Gly Ala Pro Pro
         275                 280                 285            
 Pro His Ile Trp Ala Pro Glu Thr Ala Glu Pro Ala Pro Ala Val Pro
     290                 295                 300                
 Cys Pro Glu Arg Pro Gly Cys Pro Ala Pro Ala Ala Ala Pro Arg Pro
 305                 310                 315                 320
 Leu Ser Pro Asp Pro Ala Gln Leu Pro Ala Leu Ala Arg Leu Arg Pro
                 325                 330                 335    
 Ser Pro Gly Phe Gly Glu Arg Ala His Ala Gln Pro Ala
             340                 345                



      <210> 2159
      <211> 734
      <212> PRT
      <213> Homo sapiens


      <400> 2159
 Val Pro Gly Glu Glu Cys Asp Gly Ile Thr Ser Met Ser Ala Glu Ser
   1               5                  10                  15    
 Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val Met Gly Asp Gly Leu
              20                  25                  30        
 Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln Ala Gln Pro Gln Pro
          35                  40                  45            
 Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro Glu Thr Ser Asn Pro
      50                  55                  60                
 Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln Tyr Leu Leu Arg Val
  65                  70                  75                  80
 Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala Trp Pro Phe Gln Gln
                  85                  90                  95    
 Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp Tyr Tyr Lys Ile Ile
             100                 105                 110        
 Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn
         115                 120                 125            
 Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp Phe Asn Thr Met Phe
     130                 135                 140                
 Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp Asp Ile Val Leu Met
 145                 150                 155                 160
 Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys Ile Asn Glu Leu Pro
                 165                 170                 175    
 Thr Glu Glu Thr Glu Ile Met Ile Val Gln Ala Lys Gly Arg Gly Arg
             180                 185                 190        
 Gly Arg Lys Glu Thr Gly Thr Ala Lys Pro Gly Val Ser Thr Val Pro
         195                 200                 205            
 Asn Thr Thr Gln Ala Ser Thr Pro Pro Gln Thr Gln Thr Pro Gln Pro
     210                 215                 220                
 Asn Pro Pro Pro Val Gln Ala Thr Pro His Pro Phe Pro Ala Val Thr
 225                 230                 235                 240
 Pro Asp Leu Ile Val Gln Thr Pro Val Met Thr Val Val Pro Pro Gln
                 245                 250                 255    
 Pro Leu Gln Thr Pro Pro Pro Val Pro Pro Gln Pro Gln Pro Pro Pro
             260                 265                 270        
 Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro Pro Ile Ile Ala Ala
         275                 280                 285            
 Thr Pro Gln Pro Val Lys Thr Lys Lys Gly Val Lys Arg Lys Ala Asp
     290                 295                 300                
 Thr Thr Thr Pro Thr Thr Ile Asp Pro Ile His Glu Pro Pro Ser Leu
 305                 310                 315                 320
 Pro Pro Glu Pro Lys Thr Thr Lys Leu Gly Gln Arg Arg Glu Ser Ser
                 325                 330                 335    
 Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro Asp Ser Gln Gln His
             340                 345                 350        
 Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu Gln Leu Lys Cys Cys
         355                 360                 365            
 Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys His Ala Ala Tyr Ala
     370                 375                 380                
 Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala Leu Gly Leu His Asp
 385                 390                 395                 400
 Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met Ser Thr Ile Lys Ser
                 405                 410                 415    
 Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln Glu Phe Gly Ala Asp
             420                 425                 430        
 Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His
         435                 440                 445            
 Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp Val Phe Glu Met Arg
     450                 455                 460                
 Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro Val Val Ala Val Ser
 465                 470                 475                 480
 Ser Pro Ala Val Pro Pro Pro Thr Lys Val Val Ala Pro Pro Ser Ser
                 485                 490                 495    
 Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser Asp Ser Ser Thr Asp
             500                 505                 510        
 Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala Glu Leu Gln Glu Gln
         515                 520                 525            
 Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu Ser Gln Pro Gln Gln
     530                 535                 540                
 Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys Glu Lys Lys Lys Glu
 545                 550                 555                 560
 Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn Lys Lys Ser Lys Ala
                 565                 570                 575    
 Lys Glu Pro Pro Pro Lys Lys Thr Lys Lys Asn Asn Ser Ser Asn Ser
             580                 585                 590        
 Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys Ser Lys Pro Pro Pro
         595                 600                 605            
 Thr Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys Pro Met Ser Tyr Glu
     610                 615                 620                
 Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys Leu Pro Gly Glu Lys
 625                 630                 635                 640
 Leu Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu Lys
                 645                 650                 655    
 Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys Pro
             660                 665                 670        
 Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Thr Ser Cys Leu Arg Lys
         675                 680                 685            
 Lys Arg Lys Pro Gln Ala Ser Glu Lys Val Asp Val Ile Ala Gly Ser
     690                 695                 700                
 Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu Ser Ser Ser Glu
 705                 710                 715                 720
 Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Thr Gly Pro Ala
                 725                 730                



      <210> 2160
      <211> 111
      <212> PRT
      <213> Homo sapiens


      <400> 2160
 Met Gln Ala Thr Ser Asn Leu Leu Asn Leu Leu Leu Leu Ser Leu Phe
   1               5                  10                  15    
 Ala Gly Leu Asn Pro Ser Lys Thr His Ile Asn Pro Lys Glu Gly Trp
              20                  25                  30        
 Gln Val Tyr Ser Ser Ala Gln Asp Pro Asp Gly Arg Gly Ile Cys Thr
          35                  40                  45            
 Val Val Ala Pro Glu Gln Asn Leu Cys Ser Arg Asp Ala Lys Ser Arg
      50                  55                  60                
 Gln Leu Arg Gln Leu Leu Glu Lys Val Gln Asn Met Ser Gln Ser Ile
  65                  70                  75                  80
 Glu Val Leu Asn Leu Arg Thr Gln Arg Asp Phe Gln Tyr Val Leu Lys
                  85                  90                  95    
 Met Glu Thr Gln Met Lys Gly Leu Lys Ala Lys Phe Arg Gln Ile
             100                 105                 110    



      <210> 2161
      <211> 150
      <212> PRT
      <213> Homo sapiens


      <400> 2161
 Arg Glu Glu Leu Gly Lys Asp Leu Phe Asp Cys Thr Leu Tyr Val Leu
   1               5                  10                  15    
 Leu Lys Tyr Asp Asp Phe Asn Ala Asp Lys His Leu Ala Leu Glu Glu
              20                  25                  30        
 Phe Tyr Arg Ala Phe Gln Val Ile Gln Leu Ser Leu Pro Glu Asp Gln
          35                  40                  45            
 Lys Leu Ser Ile Thr Ala Ala Thr Val Gly Gln Ser Ala Val Leu Ser
      50                  55                  60                
 Cys Ala Ile Gln Gly Thr Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn
  65                  70                  75                  80
 Asn Ile Ile Leu Asn Asn Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly
                  85                  90                  95    
 Asp Asp Gly Ser Leu Tyr Ile Thr Lys Val Thr Thr Thr His Val Gly
             100                 105                 110        
 Asn Tyr Thr Cys Tyr Ala Asp Gly Tyr Glu Gln Val Tyr Gln Thr His
         115                 120                 125            
 Ile Phe Gln Val Asn Val Pro Pro Val Ile Arg Val Tyr Pro Glu Ser
     130                 135                 140                
 Gln Ala Arg Arg Ala Gly
 145                 150



      <210> 2162
      <211> 120
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(120)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2162
 Met Phe Tyr Gln Met Ile Trp Thr Asn Gly Pro Ala Lys Leu Pro Ala
   1               5                  10                  15    
 Ser Ser Thr Lys His Asp Leu Tyr Leu Cys Asn Ser Phe Thr Gly Pro
              20                  25                  30        
 Ser Asn Ile Ile Trp Asn Leu Gly Ser Arg Tyr Ile Phe Thr Val Ile
          35                  40                  45            
 Lys His Gly Leu Gly Phe Phe Leu Asn Thr Ile Leu Ala Val Leu Asn
      50                  55                  60                
 Ile Ala Gly Arg Asn Leu Lys Cys Tyr Lys Phe Cys Xaa Thr Gly Trp
  65                  70                  75                  80
 Lys Leu Gly Trp Ser Ile Gly Pro Asn His Leu Ile Lys His Leu Gln
                  85                  90                  95    
 Thr Val Gln Gln Asn Thr Ile Tyr Ile Arg Arg Pro Ser Lys Gly Val
             100                 105                 110        
 Ala Gln Val Arg Thr Arg Gly Ser
         115                 120



      <210> 2163
      <211> 129
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(129)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2163
 Ile Thr Val Asp Arg Asn Thr Glu Thr Arg Thr Ser Ser Phe Ser Ile
   1               5                  10                  15    
 Ile Ser Val Pro Ala Ser Ser Thr Xaa Gly Ser Pro Ser Arg Val Ile
              20                  25                  30        
 Tyr Ala Lys Leu Gly Gly Glu Ile Leu Asp Tyr Arg Asp Leu Ala Ala
          35                  40                  45            
 Leu Pro Lys Ser Lys Ala Ile Tyr Asp Ile Asp Arg Pro Asp Met Ile
      50                  55                  60                
 Ser Tyr Ser Pro Tyr Ile Ser His Ser Ala Gly Asp Arg Gln Ser Tyr
  65                  70                  75                  80
 Gly Glu Ser Pro Gln Leu Leu Ser Pro Thr Pro Thr Glu Gly Asp Gln
                  85                  90                  95    
 Asp Asp Arg Ser Tyr Lys Gln Cys Arg Thr Ser Ser Pro Ser Ser Thr
             100                 105                 110        
 Gly Leu Val Ser Leu Gly Arg Tyr Thr Pro Thr Ser Arg Ala Pro Gln
         115                 120                 125            
 His
    



      <210> 2164
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 2164
 Asp Pro Arg Val Arg Phe Thr Val Cys Gly Thr Pro Thr Tyr Val Ala
   1               5                  10                  15    
 Pro Glu Ile Leu Ser Glu Lys Gly Tyr Gly Leu Glu Val Asp Met Trp
              20                  25                  30        
 Ala Ala Gly Val Ile Leu Tyr Ile Leu Leu Cys Gly Phe Pro Pro Phe
          35                  40                  45            
 Arg Ser Pro Glu Arg Asp Gln Asp Glu Leu Phe Asn Ile Ile Gln Leu
      50                  55                  60                
 Gly His Phe Glu Phe Leu Pro Pro Tyr Trp Asp Asn Ile Ser Asp Ala
  65                  70                  75                  80
 Ala Lys Asp Leu Val Ser Arg Leu Leu Val Val Asp Pro Lys Lys Arg
                  85                  90                  95    
 Tyr Thr Ala His Gln Val Leu Gln His Pro Trp Ile Glu Thr Ala Gly
             100                 105                 110        
 Glu Asp Gln Tyr Ser Glu Thr Thr Glu Ala Gly Val Pro Gln Gln Arg
         115                 120                 125            
 Gly Ser Leu Pro Glu Pro Ala Gln Glu Gly Cys Gly Ala Gly Ile Ile
     130                 135                 140                
 Val Thr Thr Leu Gly Ile Cys Pro Ala Pro Ser Ser Ala Gln Gly Gln
 145                 150                 155                 160
 Arg Lys Gly
            



      <210> 2165
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 2165
 Asp Pro Arg Val Arg Phe Thr Val Cys Gly Thr Pro Thr Tyr Val Ala
   1               5                  10                  15    
 Pro Glu Ile Leu Ser Glu Lys Gly Tyr Gly Leu Glu Val Asp Met Trp
              20                  25                  30        
 Ala Ala Gly Val Ile Leu Tyr Ile Leu Leu Cys Gly Phe Pro Pro Phe
          35                  40                  45            
 Arg Ser Pro Glu Arg Asp Gln Asp Glu Leu Phe Asn Ile Ile Gln Leu
      50                  55                  60                
 Gly His Phe Glu Phe Leu Pro Pro Tyr Trp Asp Asn Ile Ser Asp Ala
  65                  70                  75                  80
 Ala Lys Asp Leu Val Ser Arg Leu Leu Val Val Asp Pro Lys Lys Arg
                  85                  90                  95    
 Tyr Thr Ala His Gln Val Leu Gln His Pro Trp Ile Glu Thr Ala Gly
             100                 105                 110        
 Glu Asp Gln Tyr Ser Glu Thr Thr Glu Ala Gly Val Pro Gln Gln Arg
         115                 120                 125            
 Gly Ser Leu Pro Glu Pro Ala Gln Glu Gly Cys Gly Ala Gly Ile Ile
     130                 135                 140                
 Val Thr Thr Leu Gly Ile Cys Pro Ala Pro Ser Ser Ala Gln Gly Gln
 145                 150                 155                 160
 Arg Lys Gly
            



      <210> 2166
      <211> 288
      <212> PRT
      <213> Homo sapiens


      <400> 2166
 Ser Ala Ala Gln Leu Ser Leu Cys Ser Arg Leu Gln Leu Thr Leu Tyr
   1               5                  10                  15    
 Gln Tyr Thr Thr Cys Pro Phe Cys Ser Gly Val Arg Ala Phe Leu Asp
              20                  25                  30        
 Phe His Ala Leu Pro Tyr Gln Val Val Glu Val Asn Pro Glu Arg Arg
          35                  40                  45            
 Ala Glu Ile Lys Phe Ser Ser Tyr Arg Lys Val Pro Ile Leu Val Ala
      50                  55                  60                
 Gln Glu Gly Glu Ser Ser Gln Gln Leu Asn Asp Ser Ser Val Ile Ile
  65                  70                  75                  80
 Ser Ala Leu Lys Thr Tyr Leu Val Ser Gly Gln Pro Leu Glu Glu Ile
                  85                  90                  95    
 Ile Thr Tyr Tyr Pro Ala Met Lys Ala Val Asn Glu Gln Gly Lys Glu
             100                 105                 110        
 Val Thr Glu Phe Gly Asn Lys Tyr Trp Leu Met Leu Asn Glu Lys Glu
         115                 120                 125            
 Ala Gln Gln Val Tyr Gly Gly Lys Glu Ala Arg Thr Glu Glu Met Lys
     130                 135                 140                
 Trp Arg Gln Trp Ala Asp Asp Trp Leu Val His Leu Ile Ser Pro Asn
 145                 150                 155                 160
 Val Tyr Arg Thr Pro Thr Glu Ala Leu Ala Ser Phe Asp Tyr Ile Val
                 165                 170                 175    
 Arg Glu Gly Lys Phe Gly Ala Val Glu Gly Ala Val Ala Lys Tyr Met
             180                 185                 190        
 Gly Ala Ala Ala Met Tyr Leu Ile Ser Lys Arg Leu Lys Ser Arg His
         195                 200                 205            
 Arg Leu Gln Asp Asn Val Arg Glu Asp Leu Tyr Glu Ala Ala Asp Lys
     210                 215                 220                
 Trp Val Ala Ala Val Gly Lys Asp Arg Pro Phe Met Gly Gly Gln Lys
 225                 230                 235                 240
 Pro Asn Leu Ala Asp Leu Ala Val Tyr Gly Val Leu Arg Val Met Glu
                 245                 250                 255    
 Gly Leu Asp Ala Phe Asp Asp Leu Met Gln His Thr His Ile Gln Pro
             260                 265                 270        
 Trp Tyr Leu Arg Val Glu Arg Ala Ile Thr Glu Ala Ser Pro Ala His
         275                 280                 285            





      <210> 2167
      <211> 261
      <212> PRT
      <213> Homo sapiens


      <400> 2167
 Gly Arg Ile Arg Met Gln Arg Gln Ser Thr Thr Gly Gly Arg Gly Ile
   1               5                  10                  15    
 Met Glu Gly Pro Arg Gly Trp Leu Val Leu Cys Val Leu Ala Ile Ser
              20                  25                  30        
 Leu Ala Ser Met Val Thr Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys
          35                  40                  45            
 Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys
      50                  55                  60                
 Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Thr Gly Ile Gln
  65                  70                  75                  80
 Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly
                  85                  90                  95    
 Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile
             100                 105                 110        
 Pro Gly Ile Lys Gly Thr Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln
         115                 120                 125            
 Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly
     130                 135                 140                
 Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr
 145                 150                 155                 160
 Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr
                 165                 170                 175    
 Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val
             180                 185                 190        
 Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr
         195                 200                 205            
 Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln
     210                 215                 220                
 Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly
 225                 230                 235                 240
 His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu
                 245                 250                 255    
 Ile Phe Pro Ser Ala
             260    



      <210> 2168
      <211> 139
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(139)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2168
 Leu Arg Arg Phe Ser Thr Asp Cys Ser Ser Asp Gln Gln Asp Arg Leu
   1               5                  10                  15    
 Asn Gly Thr Ala Pro Ser Gly Phe Asn Arg Ser Xaa Pro Val Pro Leu
              20                  25                  30        
 Pro His Pro Ile Leu Glu Val Cys Pro Gly Gln Xaa Glu Pro Gln Ser
          35                  40                  45            
 Ala Ile Ser Leu Thr Ala Phe Gln Val Gln Ala Gly Ala Ser Arg Ala
      50                  55                  60                
 Ser Pro Gly Pro Pro Ala Pro Ser Ser Ser Lys Pro Gly Arg Lys Ala
  65                  70                  75                  80
 Lys Val Ala Ser Pro Cys Pro Asp Arg Pro Ala Pro Pro Pro Thr Xaa
                  85                  90                  95    
 Pro Arg Pro Ala Ala Ala Pro Gly Ser Glu Ser Ser Pro Arg Pro Pro
             100                 105                 110        
 Arg Pro Arg Thr Gly Arg Arg Gln Gln Arg Ala His Ala Arg Arg Ala
         115                 120                 125            
 Ala Ala Arg Thr Ala Pro Trp Arg Pro Ser Cys
     130                 135                



      <210> 2169
      <211> 745
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(745)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2169
 Glu Asn Glu Glu Gln Asp Ser Gln Asn Glu Gly Ser Thr Asp Glu Lys
   1               5                  10                  15    
 Ser Ser Pro Ala Ser Ser Gln Glu Gly Ser Pro Ser Gly Asp Gln Gln
              20                  25                  30        
 Phe Ser Pro Lys Ser Asn Thr Glu Lys Ser Lys Gly Glu Leu Met Phe
          35                  40                  45            
 Asp Asp Ser Ser Asp Ser Ser Pro Glu Lys Gln Glu Arg Asn Leu Asn
      50                  55                  60                
 Trp Thr Pro Ala Glu Val Pro Gln Leu Ala Ala Ala Lys Arg Arg Leu
  65                  70                  75                  80
 Pro Gln Gly Lys Glu Pro Gly Leu Ile Asn Leu Cys Ala Asn Val Pro
                  85                  90                  95    
 Pro Val Pro Gly Asn Ile Leu Pro Pro Glu Val Arg Gly Asn Leu Met
             100                 105                 110        
 Ala Ala Gly Gln Asn Leu Gln Ser Ser Glu Arg Ser Glu Met Ile Ala
         115                 120                 125            
 Thr Trp Ser Pro Ala Val Arg Thr Leu Arg Asn Ile Thr Asn Asn Ala
     130                 135                 140                
 Asp Ile Gln Gln Met Asn Arg Pro Ser Asn Val Ala His Ile Leu Gln
 145                 150                 155                 160
 Thr Leu Ser Ala Pro Thr Lys Asn Leu Glu Gln Gln Val Asn His Ser
                 165                 170                 175    
 Gln Gln Gly His Thr Asn Ala Asn Ala Val Leu Phe Ser Gln Val Lys
             180                 185                 190        
 Val Thr Pro Glu Thr His Met Leu Gln Gln Gln Gln Gln Ala Gln Gln
         195                 200                 205            
 Gln Gln Gln Gln His Pro Val Leu His Leu Gln Pro Gln Gln Ile Met
     210                 215                 220                
 Gln Leu Gln Gln Gln Gln Gln Gln Gln Ile Ser Gln Gln Pro Tyr Pro
 225                 230                 235                 240
 Gln Gln Pro Pro His Pro Phe Ser Gln Gln Gln Gln Gln Gln Gln Gln
                 245                 250                 255    
 Pro Pro Pro Ser Pro Gln Gln His Gln Leu Phe Gly His Asp Pro Ala
             260                 265                 270        
 Val Glu Ile Pro Glu Glu Gly Phe Leu Leu Gly Cys Val Phe Ala Ile
         275                 280                 285            
 Ala Asp Tyr Pro Glu Gln Met Ser Asp Lys Gln Leu Leu Ala Thr Trp
     290                 295                 300                
 Lys Arg Ile Ile Gln Ala His Gly Gly Thr Val Asp Pro Pro Ser Arg
 305                 310                 315                 320
 Val Asp Ala Arg Thr Phe Ser Val Arg Val Lys Ser Ala Ala Arg Ile
                 325                 330                 335    
 Ala Gln Ala Ile Arg Glu Arg Lys Arg Cys Val Thr Ala His Trp Leu
             340                 345                 350        
 Asn Thr Val Leu Lys Lys Lys Lys Met Val Pro Pro His Arg Ala Leu
         355                 360                 365            
 His Phe Pro Val Ala Phe Pro Pro Gly Gly Lys Pro Cys Ser Gln His
     370                 375                 380                
 Ile Ile Ser Val Thr Gly Phe Val Asp Ser Asp Arg Asp Asp Leu Lys
 385                 390                 395                 400
 Leu Met Ala Tyr Leu Ala Gly Ala Lys Tyr Thr Gly Tyr Leu Cys Arg
                 405                 410                 415    
 Ser Asn Thr Val Leu Ile Cys Lys Glu Pro Thr Gly Leu Lys Tyr Glu
             420                 425                 430        
 Lys Ala Lys Glu Trp Arg Ile Pro Cys Val Asn Ala Gln Trp Leu Gly
         435                 440                 445            
 Asp Ile Leu Leu Gly Asn Phe Glu Ala Leu Arg Gln Ile Gln Tyr Ser
     450                 455                 460                
 Arg Tyr Thr Ala Phe Ser Leu Gln Asp Pro Phe Ala Pro Thr Gln His
 465                 470                 475                 480
 Leu Val Leu Asn Leu Leu Asp Ala Trp Arg Val Pro Leu Lys Val Ser
                 485                 490                 495    
 Ala Glu Leu Leu Met Ser Ile Arg Leu Pro Pro Lys Leu Lys Gln Asn
             500                 505                 510        
 Glu Val Ala Asn Val Gln Pro Ser Ser Lys Arg Ala Arg Ile Glu Asp
         515                 520                 525            
 Val Pro Pro Pro Thr Lys Lys Leu Thr Pro Glu Leu Thr Pro Phe Val
     530                 535                 540                
 Leu Phe Thr Gly Phe Glu Pro Val Gln Val Gln Gln Tyr Ile Lys Lys
 545                 550                 555                 560
 Leu Tyr Ile Leu Gly Gly Glu Val Ala Glu Ser Ala Gln Lys Cys Thr
                 565                 570                 575    
 His Leu Ile Ala Ser Lys Val Thr Arg Thr Val Lys Phe Leu Ala Ala
             580                 585                 590        
 Ile Ser Val Val Lys His Ile Val Thr Pro Glu Trp Leu Glu Glu Cys
         595                 600                 605            
 Phe Arg Cys Gln Lys Phe Ile Asp Glu Gln Asn Tyr Ile Leu Arg Asp
     610                 615                 620                
 Ala Glu Ala Glu Val Leu Phe Ser Phe Ser Leu Glu Glu Ser Leu Lys
 625                 630                 635                 640
 Arg Ala His Val Ser Pro Leu Phe Lys Ala Lys Tyr Phe Tyr Ile Thr
                 645                 650                 655    
 Pro Gly Ile Cys Pro Ser Leu Ser Thr Met Lys Ala Ile Val Glu Cys
             660                 665                 670        
 Ala Gly Gly Lys Val Leu Ser Lys Gln Pro Ser Phe Arg Lys Leu Met
         675                 680                 685            
 Gly Ala Gln Ala Gly Thr Ser Ser Leu Phe Gly Lys Xaa Phe Xaa Leu
     690                 695                 700                
 Ser Cys Glu Asn Asp Leu His Phe Ile Arg Glu Tyr Phe Ala Arg Gly
 705                 710                 715                 720
 Ile Asp Val His Asn Ala Glu Phe Val Leu Thr Glu Val Leu Thr Gln
                 725                 730                 735    
 Thr Leu Asp Tyr Glu Ser Tyr Lys Val
             740                 745



      <210> 2170
      <211> 745
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(745)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2170
 Glu Asn Glu Glu Gln Asp Ser Gln Asn Glu Gly Ser Thr Asp Glu Lys
   1               5                  10                  15    
 Ser Ser Pro Ala Ser Ser Gln Glu Gly Ser Pro Ser Gly Asp Gln Gln
              20                  25                  30        
 Phe Ser Pro Lys Ser Asn Thr Glu Lys Ser Lys Gly Glu Leu Met Phe
          35                  40                  45            
 Asp Asp Ser Ser Asp Ser Ser Pro Glu Lys Gln Glu Arg Asn Leu Asn
      50                  55                  60                
 Trp Thr Pro Ala Glu Val Pro Gln Leu Ala Ala Ala Lys Arg Arg Leu
  65                  70                  75                  80
 Pro Gln Gly Lys Glu Pro Gly Leu Ile Asn Leu Cys Ala Asn Val Pro
                  85                  90                  95    
 Pro Val Pro Gly Asn Ile Leu Pro Pro Glu Val Arg Gly Asn Leu Met
             100                 105                 110        
 Ala Ala Gly Gln Asn Leu Gln Ser Ser Glu Arg Ser Glu Met Ile Ala
         115                 120                 125            
 Thr Trp Ser Pro Ala Val Arg Thr Leu Arg Asn Ile Thr Asn Asn Ala
     130                 135                 140                
 Asp Ile Gln Gln Met Asn Arg Pro Ser Asn Val Ala His Ile Leu Gln
 145                 150                 155                 160
 Thr Leu Ser Ala Pro Thr Lys Asn Leu Glu Gln Gln Val Asn His Ser
                 165                 170                 175    
 Gln Gln Gly His Thr Asn Ala Asn Ala Val Leu Phe Ser Gln Val Lys
             180                 185                 190        
 Val Thr Pro Glu Thr His Met Leu Gln Gln Gln Gln Gln Ala Gln Gln
         195                 200                 205            
 Gln Gln Gln Gln His Pro Val Leu His Leu Gln Pro Gln Gln Ile Met
     210                 215                 220                
 Gln Leu Gln Gln Gln Gln Gln Gln Gln Ile Ser Gln Gln Pro Tyr Pro
 225                 230                 235                 240
 Gln Gln Pro Pro His Pro Phe Ser Gln Gln Gln Gln Gln Gln Gln Gln
                 245                 250                 255    
 Pro Pro Pro Ser Pro Gln Gln His Gln Leu Phe Gly His Asp Pro Ala
             260                 265                 270        
 Val Glu Ile Pro Glu Glu Gly Phe Leu Leu Gly Cys Val Phe Ala Ile
         275                 280                 285            
 Ala Asp Tyr Pro Glu Gln Met Ser Asp Lys Gln Leu Leu Ala Thr Trp
     290                 295                 300                
 Lys Arg Ile Ile Gln Ala His Gly Gly Thr Val Asp Pro Pro Ser Arg
 305                 310                 315                 320
 Val Asp Ala Arg Thr Phe Ser Val Arg Val Lys Ser Ala Ala Arg Ile
                 325                 330                 335    
 Ala Gln Ala Ile Arg Glu Arg Lys Arg Cys Val Thr Ala His Trp Leu
             340                 345                 350        
 Asn Thr Val Leu Lys Lys Lys Lys Met Val Pro Pro His Arg Ala Leu
         355                 360                 365            
 His Phe Pro Val Ala Phe Pro Pro Gly Gly Lys Pro Cys Ser Gln His
     370                 375                 380                
 Ile Ile Ser Val Thr Gly Phe Val Asp Ser Asp Arg Asp Asp Leu Lys
 385                 390                 395                 400
 Leu Met Ala Tyr Leu Ala Gly Ala Lys Tyr Thr Gly Tyr Leu Cys Arg
                 405                 410                 415    
 Ser Asn Thr Val Leu Ile Cys Lys Glu Pro Thr Gly Leu Lys Tyr Glu
             420                 425                 430        
 Lys Ala Lys Glu Trp Arg Ile Pro Cys Val Asn Ala Gln Trp Leu Gly
         435                 440                 445            
 Asp Ile Leu Leu Gly Asn Phe Glu Ala Leu Arg Gln Ile Gln Tyr Ser
     450                 455                 460                
 Arg Tyr Thr Ala Phe Ser Leu Gln Asp Pro Phe Ala Pro Thr Gln His
 465                 470                 475                 480
 Leu Val Leu Asn Leu Leu Asp Ala Trp Arg Val Pro Leu Lys Val Ser
                 485                 490                 495    
 Ala Glu Leu Leu Met Ser Ile Arg Leu Pro Pro Lys Leu Lys Gln Asn
             500                 505                 510        
 Glu Val Ala Asn Val Gln Pro Ser Ser Lys Arg Ala Arg Ile Glu Asp
         515                 520                 525            
 Val Pro Pro Pro Thr Lys Lys Leu Thr Pro Glu Leu Thr Pro Phe Val
     530                 535                 540                
 Leu Phe Thr Gly Phe Glu Pro Val Gln Val Gln Gln Tyr Ile Lys Lys
 545                 550                 555                 560
 Leu Tyr Ile Leu Gly Gly Glu Val Ala Glu Ser Ala Gln Lys Cys Thr
                 565                 570                 575    
 His Leu Ile Ala Ser Lys Val Thr Arg Thr Val Lys Phe Leu Ala Ala
             580                 585                 590        
 Ile Ser Val Val Lys His Ile Val Thr Pro Glu Trp Leu Glu Glu Cys
         595                 600                 605            
 Phe Arg Cys Gln Lys Phe Ile Asp Glu Gln Asn Tyr Ile Leu Arg Asp
     610                 615                 620                
 Ala Glu Ala Glu Val Leu Phe Ser Phe Ser Leu Glu Glu Ser Leu Lys
 625                 630                 635                 640
 Arg Ala His Val Ser Pro Leu Phe Lys Ala Lys Tyr Phe Tyr Ile Thr
                 645                 650                 655    
 Pro Gly Ile Cys Pro Ser Leu Ser Thr Met Lys Ala Ile Val Glu Cys
             660                 665                 670        
 Ala Gly Gly Lys Val Leu Ser Lys Gln Pro Ser Phe Arg Lys Leu Met
         675                 680                 685            
 Gly Ala Gln Ala Gly Thr Ser Ser Leu Phe Gly Lys Xaa Phe Xaa Leu
     690                 695                 700                
 Ser Cys Glu Asn Asp Leu His Phe Ile Arg Glu Tyr Phe Ala Arg Gly
 705                 710                 715                 720
 Ile Asp Val His Asn Ala Glu Phe Val Leu Thr Glu Val Leu Thr Gln
                 725                 730                 735    
 Thr Leu Asp Tyr Glu Ser Tyr Lys Val
             740                 745



      <210> 2171
      <211> 192
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(192)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2171
 Gly Arg Arg Leu Arg Ser Glu Pro Arg Pro Ala Arg Pro Pro Ile Ala
   1               5                  10                  15    
 Arg Ala Trp Pro Pro Ala Pro Gly Ala Asp Gly Arg Ala Arg Arg Thr
              20                  25                  30        
 Arg Val Pro Ala Pro Cys Leu Pro Arg Ala Pro Cys Tyr Gly Val Arg
          35                  40                  45            
 Pro Arg Ala Trp Arg Pro Arg Pro Ala Arg Leu Arg Gly Gly Leu Val
      50                  55                  60                
 Arg Trp Leu Leu Ser Gly Gly Pro Gln Pro Arg Arg Pro Arg Ala Thr
  65                  70                  75                  80
 Glu Arg Pro Ser Ala Gly Thr Gly Ala Ala Pro Arg Arg Thr Glu Pro
                  85                  90                  95    
 Arg Gly Arg Cys Arg Gly Cys Gly Arg Gly Arg Gly Xaa Gly Pro Arg
             100                 105                 110        
 Ala Trp Gly Leu Ala Leu Cys Ser Pro His Ser Cys Ser Gly Ala Ala
         115                 120                 125            
 Trp Gly Pro Thr Thr Gly Ser Gln Arg Ser Trp Pro Ala Val Ala Arg
     130                 135                 140                
 Ser Trp Gln Gly Asp Ser Ser Arg Cys Pro Ala Leu Arg Thr Thr Thr
 145                 150                 155                 160
 Val Thr Ala Gly Ser Lys Ala Ala Leu Pro Glu Ser Ala Ala Glu Val
                 165                 170                 175    
 Ser Pro Met Ser Ser Ser Pro Gly Arg Lys Arg Ser Gly Phe Ala Ala
             180                 185                 190        





      <210> 2172
      <211> 308
      <212> PRT
      <213> Homo sapiens


      <400> 2172
 Ser Glu Gln Lys Ile Gln Glu Gln Gly Tyr Val Trp Ile Thr Val Phe
   1               5                  10                  15    
 Ser Ala Leu Pro Thr Thr Val Ser Ala Leu His Pro Arg Val Leu Lys
              20                  25                  30        
 Pro Leu Ser Ser Leu Ile His Leu Gln Ala Asn Ser Asn Pro Trp Glu
          35                  40                  45            
 Cys Asn Cys Lys Leu Leu Gly Leu Arg Asp Trp Leu Ala Ser Ser Ala
      50                  55                  60                
 Ile Thr Leu Asn Ile Tyr Trp Gln Asn Pro Pro Ser Met Arg Gly Arg
  65                  70                  75                  80
 Ala Leu Arg Tyr Ile Asn Ile Thr Asn Cys Val Thr Ser Ser Ile Asn
                  85                  90                  95    
 Val Ser Arg Ala Trp Ala Val Val Lys Ser Pro His Ile His His Lys
             100                 105                 110        
 Thr Thr Ala Leu Met Met Ala Trp His Lys Val Thr Thr Asn Gly Ser
         115                 120                 125            
 Pro Leu Glu Asn Thr Glu Thr Glu Asn Ile Thr Phe Trp Glu Arg Ile
     130                 135                 140                
 Pro Thr Ser Pro Ala Gly Arg Phe Phe Gln Glu Asn Ala Phe Gly Asn
 145                 150                 155                 160
 Pro Leu Glu Thr Thr Ala Val Leu Pro Val Gln Ile Gln Leu Thr Thr
                 165                 170                 175    
 Ser Val Thr Leu Asn Leu Glu Lys Asn Ser Ala Leu Pro Asn Asp Ala
             180                 185                 190        
 Ala Ser Met Ser Gly Lys Thr Ser Leu Ile Cys Thr Gln Glu Val Glu
         195                 200                 205            
 Lys Leu Asn Glu Ala Phe Asp Ile Leu Leu Ala Phe Phe Ile Leu Ala
     210                 215                 220                
 Cys Val Leu Ile Ile Phe Leu Ile Tyr Lys Val Val Gln Phe Lys Gln
 225                 230                 235                 240
 Lys Leu Lys Ala Ser Glu Asn Ser Arg Glu Asn Arg Leu Glu Tyr Tyr
                 245                 250                 255    
 Ser Phe Tyr Gln Ser Ala Arg Tyr Asn Val Thr Ala Ser Ile Cys Asn
             260                 265                 270        
 Thr Ser Pro Asn Ser Leu Glu Ser Pro Gly Leu Glu Gln Ile Arg Leu
         275                 280                 285            
 His Lys Gln Ile Val Pro Glu Asn Glu Ala Gln Val Ile Leu Phe Glu
     290                 295                 300                
 His Ser Ala Leu
 305            



      <210> 2173
      <211> 240
      <212> PRT
      <213> Homo sapiens


      <400> 2173
 Ala Val Arg Leu Asn Ile Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr
   1               5                  10                  15    
 Val Phe Gln Gly Asp Gly Thr Ala Ser Thr Thr Leu Arg Asn Gly Ser
              20                  25                  30        
 Ala Leu Ser Val Leu Glu Gly Gln Ser Leu His Leu Val Cys Ala Val
          35                  40                  45            
 Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp Gly Ser Leu Thr
      50                  55                  60                
 Leu Ser Pro Ser Gln Ser Ser Asn Leu Gly Val Leu Glu Leu Pro Arg
  65                  70                  75                  80
 Val His Val Lys Asp Glu Gly Glu Phe Thr Cys Arg Ala Gln Asn Pro
                  85                  90                  95    
 Leu Gly Ser Gln His Ile Ser Leu Ser Leu Ser Leu Gln Asn Glu Tyr
             100                 105                 110        
 Thr Gly Lys Met Arg Pro Ile Ser Gly Val Met Leu Gly Ala Phe Gly
         115                 120                 125            
 Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys Ile Ile Phe
     130                 135                 140                
 Val Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Val Gly
 145                 150                 155                 160
 Val Gly Asp Thr Gly Met Glu Asp Ala Asn Ala Val Arg Gly Ser Ala
                 165                 170                 175    
 Ser Gln Gly Pro Leu Ile Glu Ser Pro Ala Asp Asp Ser Pro Pro His
             180                 185                 190        
 His Ala Pro Pro Ala Leu Ala Thr Pro Ser Pro Glu Glu Gly Glu Ile
         195                 200                 205            
 Gln Tyr Ala Ser Leu Ser Phe His Lys Ala Arg Pro Gln Tyr Pro Gln
     210                 215                 220                
 Glu Gln Glu Ala Ile Gly Tyr Glu Tyr Ser Glu Ile Asn Ile Pro Lys
 225                 230                 235                 240





      <210> 2174
      <211> 270
      <212> PRT
      <213> Homo sapiens


      <400> 2174
 Ser His Ile Gln His His Gly Arg Gly Ala Gln Ala Pro Val Lys Met
   1               5                  10                  15    
 Val Ser Trp Met Ile Ser Arg Ala Val Val Leu Val Phe Gly Met Leu
              20                  25                  30        
 Tyr Pro Ala Tyr Tyr Ser Tyr Lys Ala Val Lys Thr Lys Asn Val Lys
          35                  40                  45            
 Glu Tyr Val Arg Trp Met Met Tyr Trp Ile Val Phe Ala Leu Tyr Thr
      50                  55                  60                
 Val Ile Glu Thr Val Ala Asp Gln Thr Val Ala Trp Phe Pro Leu Tyr
  65                  70                  75                  80
 Tyr Glu Leu Lys Ile Ala Phe Val Ile Trp Leu Leu Ser Pro Tyr Thr
                  85                  90                  95    
 Lys Gly Ala Ser Leu Ile Tyr Arg Lys Phe Leu His Pro Leu Leu Ser
             100                 105                 110        
 Ser Lys Glu Arg Glu Ile Asp Asp Tyr Ile Val Gln Ala Lys Glu Arg
         115                 120                 125            
 Gly Tyr Glu Thr Met Val Asn Phe Gly Arg Gln Gly Leu Asn Leu Ala
     130                 135                 140                
 Ala Thr Ala Ala Val Thr Ala Ala Val Lys Ser Gln Gly Ala Ile Thr
 145                 150                 155                 160
 Glu Arg Leu Arg Ser Phe Ser Met His Asp Leu Thr Thr Ile Gln Gly
                 165                 170                 175    
 Asp Glu Pro Val Gly Gln Arg Pro Tyr Gln Pro Leu Pro Glu Ala Lys
             180                 185                 190        
 Lys Lys Ser Lys Pro Ala Pro Ser Glu Ser Ala Gly Tyr Gly Ile Pro
         195                 200                 205            
 Leu Lys Asp Gly Asp Glu Lys Thr Asp Glu Glu Ala Glu Gly Pro Tyr
     210                 215                 220                
 Ser Asp Asn Glu Met Leu Thr His Lys Gly Pro Arg Arg Ser Gln Ser
 225                 230                 235                 240
 Met Lys Ser Val Lys Thr Thr Lys Gly Arg Lys Glu Val Arg Tyr Gly
                 245                 250                 255    
 Ser Leu Lys Tyr Lys Val Lys Lys Arg Pro Gln Val Tyr Phe
             260                 265                 270



      <210> 2175
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 2175
 Arg Gly Tyr Asn Pro Asn Val Asn Ala Gly Ile Ile Asn Ser Phe Ala
   1               5                  10                  15    
 Thr Ala Ala Phe Arg Phe Gly His Thr Leu Ile Asn Pro Ile Leu Tyr
              20                  25                  30        
 Arg Leu Asn Ala Thr Leu Gly Glu Ile Ser Glu Gly His Leu Pro Phe
          35                  40                  45            
 His Lys Ala Leu Phe Ser Pro Ser Arg Ile Ile Lys Glu Gly Gly Ile
      50                  55                  60                
 Asp Pro Val Leu Arg Gly Leu Phe Gly Val Ala Ala Lys Trp Arg Ala
  65                  70                  75                  80
 Pro Ser Tyr Leu Leu Ser Pro Glu Leu Thr Gln Arg Leu Phe Ser Ala
                  85                  90                  95    
 Ala Tyr Ser Ala Ala Val Asp Ser Ala Ala Thr Ile Ile Gln Arg Gly
             100                 105                 110        
 Arg Asp His Gly Ile Pro Pro Tyr Val Asp Phe Arg Val Phe Cys Asn
         115                 120                 125            
 Leu Thr Ser Val Lys Asn Phe Glu Asp Leu Gln Asn Glu Ile Lys Asp
     130                 135                 140                
 Ser Glu Ile Arg Gln Lys Leu Arg Lys Leu Tyr Gly Ser Pro Gly Asp
 145                 150                 155                 160
 Ile Asp Leu Trp Pro Ala Leu Met Val Glu Asp Leu Ile Pro Gly Thr
                 165                 170                 175    
 Arg Val Gly Pro Thr Leu Met Cys Met Leu Ser Thr Gln Phe Gln Arg
             180                 185                 190        
 Leu Arg Asp Gly Asp Arg Phe Trp Tyr Glu Asn Pro Gly Val Phe Thr
         195                 200                 205            
 Pro Ala Gln Leu Thr Gln Leu Lys Gln Ala Ser Leu Ser Arg Val Leu
     210                 215                 220                
 Cys Asp Asn Gly Asp Ser Ile Gln Gln Val Gln Ala Asp Val Phe Arg
 225                 230                 235                 240
 Lys Arg Gln Glu Tyr Pro Gln Asp Tyr Leu Asn Cys Lys Arg Glu Ser
                 245                 250                 255    
 Pro Asn Val Asp Pro Ala Lys Cys
             260                



      <210> 2176
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 2176
 Arg Gly Tyr Asn Pro Asn Val Asn Ala Gly Ile Ile Asn Ser Phe Ala
   1               5                  10                  15    
 Thr Ala Ala Phe Arg Phe Gly His Thr Leu Ile Asn Pro Ile Leu Tyr
              20                  25                  30        
 Arg Leu Asn Ala Thr Leu Gly Glu Ile Ser Glu Gly His Leu Pro Phe
          35                  40                  45            
 His Lys Ala Leu Phe Ser Pro Ser Arg Ile Ile Lys Glu Gly Gly Ile
      50                  55                  60                
 Asp Pro Val Leu Arg Gly Leu Phe Gly Val Ala Ala Lys Trp Arg Ala
  65                  70                  75                  80
 Pro Ser Tyr Leu Leu Ser Pro Glu Leu Thr Gln Arg Leu Phe Ser Ala
                  85                  90                  95    
 Ala Tyr Ser Ala Ala Val Asp Ser Ala Ala Thr Ile Ile Gln Arg Gly
             100                 105                 110        
 Arg Asp His Gly Ile Pro Pro Tyr Val Asp Phe Arg Val Phe Cys Asn
         115                 120                 125            
 Leu Thr Ser Val Lys Asn Phe Glu Asp Leu Gln Asn Glu Ile Lys Asp
     130                 135                 140                
 Ser Glu Ile Arg Gln Lys Leu Arg Lys Leu Tyr Gly Ser Pro Gly Asp
 145                 150                 155                 160
 Ile Asp Leu Trp Pro Ala Leu Met Val Glu Asp Leu Ile Pro Gly Thr
                 165                 170                 175    
 Arg Val Gly Pro Thr Leu Met Cys Met Leu Ser Thr Gln Phe Gln Arg
             180                 185                 190        
 Leu Arg Asp Gly Asp Arg Phe Trp Tyr Glu Asn Pro Gly Val Phe Thr
         195                 200                 205            
 Pro Ala Gln Leu Thr Gln Leu Lys Gln Ala Ser Leu Ser Arg Val Leu
     210                 215                 220                
 Cys Asp Asn Gly Asp Ser Ile Gln Gln Val Gln Ala Asp Val Phe Arg
 225                 230                 235                 240
 Lys Arg Gln Glu Tyr Pro Gln Asp Tyr Leu Asn Cys Lys Arg Glu Ser
                 245                 250                 255    
 Pro Asn Val Asp Pro Ala Lys Cys
             260                



      <210> 2177
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 2177
 Arg Gly Tyr Asn Pro Asn Val Asn Ala Gly Ile Ile Asn Ser Phe Ala
   1               5                  10                  15    
 Thr Ala Ala Phe Arg Phe Gly His Thr Leu Ile Asn Pro Ile Leu Tyr
              20                  25                  30        
 Arg Leu Asn Ala Thr Leu Gly Glu Ile Ser Glu Gly His Leu Pro Phe
          35                  40                  45            
 His Lys Ala Leu Phe Ser Pro Ser Arg Ile Ile Lys Glu Gly Gly Ile
      50                  55                  60                
 Asp Pro Val Leu Arg Gly Leu Phe Gly Val Ala Ala Lys Trp Arg Ala
  65                  70                  75                  80
 Pro Ser Tyr Leu Leu Ser Pro Glu Leu Thr Gln Arg Leu Phe Ser Ala
                  85                  90                  95    
 Ala Tyr Ser Ala Ala Val Asp Ser Ala Ala Thr Ile Ile Gln Arg Gly
             100                 105                 110        
 Arg Asp His Gly Ile Pro Pro Tyr Val Asp Phe Arg Val Phe Cys Asn
         115                 120                 125            
 Leu Thr Ser Val Lys Asn Phe Glu Asp Leu Gln Asn Glu Ile Lys Asp
     130                 135                 140                
 Ser Glu Ile Arg Gln Lys Leu Arg Lys Leu Tyr Gly Ser Pro Gly Asp
 145                 150                 155                 160
 Ile Asp Leu Trp Pro Ala Leu Met Val Glu Asp Leu Ile Pro Gly Thr
                 165                 170                 175    
 Arg Val Gly Pro Thr Leu Met Cys Met Leu Ser Thr Gln Phe Gln Arg
             180                 185                 190        
 Leu Arg Asp Gly Asp Arg Phe Trp Tyr Glu Asn Pro Gly Val Phe Thr
         195                 200                 205            
 Pro Ala Gln Leu Thr Gln Leu Lys Gln Ala Ser Leu Ser Arg Val Leu
     210                 215                 220                
 Cys Asp Asn Gly Asp Ser Ile Gln Gln Val Gln Ala Asp Val Phe Arg
 225                 230                 235                 240
 Lys Arg Gln Glu Tyr Pro Gln Asp Tyr Leu Asn Cys Lys Arg Glu Ser
                 245                 250                 255    
 Pro Asn Val Asp Pro Ala Lys Cys
             260                



      <210> 2178
      <211> 103
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(103)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2178
 Ala Gly Val Lys Trp Tyr Glu His Gly Leu Trp Gln Pro Pro Pro Pro
   1               5                  10                  15    
 Gly Leu Lys Arg Ser Ser His Leu Ser Leu Pro Ser Ser Xaa Asp His
              20                  25                  30        
 Arg His Glu Tyr Pro Cys Pro Ala Asn Phe Xaa Lys Ile Phe Phe Val
          35                  40                  45            
 Glu Thr Arg Ser His Tyr Val Ala Gln Thr Ser Leu Glu Phe Leu Asp
      50                  55                  60                
 Ser Ser Asn Pro Pro Thr Ser Ala Ser Gln Asn Ala Gly Ile Xaa Gly
  65                  70                  75                  80
 Met Ser His Cys Ala Gln Pro Met Gln Thr Phe Ser Leu Val Lys Ile
                  85                  90                  95    
 Gly Thr Asn Phe Leu Ile Phe
             100            



      <210> 2179
      <211> 650
      <212> PRT
      <213> Homo sapiens


      <400> 2179
 Ala Glu Lys Lys Met Leu Pro Val Asp Gly Glu Glu Arg Lys Ser Glu
   1               5                  10                  15    
 Gly Ser Asp Thr Glu Gly Asp Arg Thr Ser Pro Cys Ala Val Ser Ser
              20                  25                  30        
 Leu Ile Val Ser Asn Arg Tyr Pro Arg Gly Gly Pro Tyr Ile Ile Ala
          35                  40                  45            
 Thr Leu Lys Asp Leu Glu Val Gly Gly Ser Gly Arg Arg Cys Ser Asp
      50                  55                  60                
 Pro Ala Gly Gln Pro Ser Asn Leu Leu Pro Gln Arg Gly Leu Gly Ala
  65                  70                  75                  80
 Pro Leu Pro Ala Glu Thr Ala His Thr Gln Pro Ser Pro Asn Asp Arg
                  85                  90                  95    
 Ser Leu Tyr Leu Ser Pro Lys Ser Ser Ser Ala Ser Ser Ser Leu His
             100                 105                 110        
 Ala Arg Gln Ser Pro Cys Gln Glu Gln Ala Ala Val Leu Asn Ser Arg
         115                 120                 125            
 Ser Ile Lys Ile Ser Arg Leu Asn Asp Thr Ile Lys Ser Leu Lys Gln
     130                 135                 140                
 Gln Lys Lys Gln Val Glu His Gln Leu Glu Glu Glu Lys Lys Ala Asn
 145                 150                 155                 160
 Asn Glu Lys Gln Lys Ala Glu Arg Glu Leu Glu Gly Gln Ile Gln Arg
                 165                 170                 175    
 Leu Asn Ile Glu Lys Lys Lys Leu Asn Thr Asp Leu Tyr His Met Lys
             180                 185                 190        
 His Ser Leu Arg Tyr Phe Glu Glu Glu Ser Lys Asp Leu Ala Gly Arg
         195                 200                 205            
 Leu Gln Arg Ser Ser Gln Arg Ile Gly Glu Leu Glu Trp Ser Leu Cys
     210                 215                 220                
 Ala Val Ala Ala Thr Gln Lys Lys Lys Pro Asp Gly Phe Ser Ser Arg
 225                 230                 235                 240
 Ser Lys Ala Leu Leu Lys Arg Gln Leu Glu Gln Ser Ile Arg Glu Gln
                 245                 250                 255    
 Ile Leu Leu Lys Gly His Val Thr Gln Leu Lys Glu Ser Leu Lys Glu
             260                 265                 270        
 Val Gln Leu Glu Arg Asp Gln Tyr Ala Glu Gln Ile Lys Gly Glu Arg
         275                 280                 285            
 Ala Gln Trp Gln Gln Arg Met Arg Lys Met Ser Gln Glu Val Cys Thr
     290                 295                 300                
 Leu Lys Glu Glu Lys Lys His Asp Thr His Arg Val Glu Glu Leu Glu
 305                 310                 315                 320
 Arg Ser Leu Ser Arg Leu Lys Asn Gln Met Ala Glu Pro Leu Pro Pro
                 325                 330                 335    
 Asp Ala Pro Ala Val Ser Ser Glu Val Glu Leu Gln Asp Leu Arg Lys
             340                 345                 350        
 Glu Leu Glu Arg Val Ala Gly Glu Leu Gln Ala Gln Val Glu Asn Asn
         355                 360                 365            
 Gln Cys Ile Ser Leu Leu Asn Arg Gly Gln Lys Glu Arg Leu Arg Glu
     370                 375                 380                
 Gln Glu Glu Arg Leu Gln Glu Gln Gln Glu Arg Leu Arg Glu Arg Glu
 385                 390                 395                 400
 Lys Arg Leu Gln Gln Leu Ala Glu Pro Gln Ser Asp Leu Glu Glu Leu
                 405                 410                 415    
 Lys His Glu Asn Lys Ser Ala Leu Gln Leu Glu Gln Gln Val Lys Glu
             420                 425                 430        
 Leu Gln Glu Lys Leu Gly Gln Val Met Glu Thr Leu Thr Ser Ala Glu
         435                 440                 445            
 Lys Glu Pro Glu Ala Ala Val Pro Ala Ser Gly Thr Gly Gly Glu Ser
     450                 455                 460                
 Ser Gly Leu Met Asp Leu Leu Glu Glu Lys Ala Asp Leu Arg Glu His
 465                 470                 475                 480
 Val Glu Lys Leu Glu Leu Gly Phe Ile Gln Tyr Arg Arg Glu Arg Cys
                 485                 490                 495    
 His Gln Asn Val His Arg Leu Leu Thr Glu Pro Gly Asp Ser Ala Lys
             500                 505                 510        
 Asp Ala Ser Pro Gly Gly Gly His His Gln Ala Gly Pro Gly Gln Gly
         515                 520                 525            
 Gly Glu Glu Gly Glu Ala Ala Gly Ala Ala Gly Asp Gly Val Ala Ala
     530                 535                 540                
 Cys Gly Ser Tyr Ser Glu Gly His Gly Lys Phe Leu Ala Ala Ala Gln
 545                 550                 555                 560
 Asn Pro Ala Ala Glu Pro Ser Pro Gly Ala Pro Ala Pro Gln Glu Leu
                 565                 570                 575    
 Gly Ala Ala Asp Lys His Gly Asp Leu Cys Glu Ala Ser Leu Thr Asn
             580                 585                 590        
 Ser Val Glu Pro Ala Gln Gly Glu Ala Arg Glu Gly Ser Ser Gln Asp
         595                 600                 605            
 Asn Pro Thr Ala Gln Pro Ile Val Gln Leu Leu Gly Glu Met Gln Asp
     610                 615                 620                
 His Gln Glu His Pro Gly Leu Gly Ser Asn Cys Cys Val Pro Cys Phe
 625                 630                 635                 640
 Cys Trp Ala Trp Leu Pro Arg Arg Arg Arg
                 645                 650



      <210> 2180
      <211> 423
      <212> PRT
      <213> Homo sapiens


      <400> 2180
 Gly Gly Ala Leu Gln Cys Gly Asp Pro Leu Ala Arg Ser Pro Ala Val
   1               5                  10                  15    
 Pro Ala Pro Arg Val Pro Ala Gln Pro Pro Pro Gly Leu Gly Arg Arg
              20                  25                  30        
 Ala Ser Arg Lys Glu Ala Ala Thr Leu Ala Met Ala Ser Pro Pro Ala
          35                  40                  45            
 Cys Pro Ser Glu Glu Asp Glu Ser Leu Lys Gly Cys Glu Leu Tyr Val
      50                  55                  60                
 Gln Leu His Gly Ile Gln Gln Val Leu Lys Asp Cys Ile Val His Leu
  65                  70                  75                  80
 Cys Ile Ser Lys Pro Glu Arg Pro Met Lys Phe Leu Arg Glu His Phe
                  85                  90                  95    
 Glu Lys Leu Glu Lys Glu Glu Asn Arg Gln Ile Leu Ala Arg Gln Lys
             100                 105                 110        
 Ser Asn Ser Gln Ser Asp Ser His Asp Glu Glu Val Ser Pro Thr Pro
         115                 120                 125            
 Pro Asn Pro Val Val Lys Ala Arg Arg Arg Arg Gly Gly Val Ser Ala
     130                 135                 140                
 Glu Val Tyr Thr Glu Glu Asp Ala Val Ser Tyr Val Arg Lys Val Ile
 145                 150                 155                 160
 Pro Lys Asp Tyr Lys Thr Met Thr Ala Leu Ala Lys Ala Ile Ser Lys
                 165                 170                 175    
 Asn Val Leu Phe Ala His Leu Asp Asp Asn Glu Arg Ser Asp Ile Phe
             180                 185                 190        
 Asp Ala Met Phe Pro Val Thr His Ile Ala Gly Glu Thr Val Ile Gln
         195                 200                 205            
 Gln Gly Asn Glu Gly Asp Asn Phe Tyr Val Val Asp Gln Gly Glu Val
     210                 215                 220                
 Asp Val Tyr Val Asn Gly Glu Trp Val Thr Asn Ile Ser Glu Gly Gly
 225                 230                 235                 240
 Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly Thr Pro Arg Ala Ala Thr
                 245                 250                 255    
 Val Lys Ala Lys Thr Asp Leu Lys Leu Trp Gly Ile Asp Arg Asp Ser
             260                 265                 270        
 Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu Arg Lys Arg Lys Met Tyr
         275                 280                 285            
 Glu Glu Phe Leu Ser Lys Val Ser Ile Leu Glu Ser Leu Glu Lys Trp
     290                 295                 300                
 Glu Arg Leu Thr Val Ala Asp Ala Leu Glu Pro Val Gln Phe Glu Asp
 305                 310                 315                 320
 Gly Glu Lys Ile Val Val Gln Gly Glu Pro Gly Asp Asp Phe Tyr Ile
                 325                 330                 335    
 Ile Thr Glu Gly Thr Ala Ser Val Leu Gln Arg Arg Ser Pro Asn Glu
             340                 345                 350        
 Glu Tyr Val Glu Val Gly Arg Leu Gly Pro Ser Asp Tyr Phe Gly Glu
         355                 360                 365            
 Ile Ala Leu Leu Leu Asn Arg Pro Arg Ala Ala Thr Val Val Ala Arg
     370                 375                 380                
 Gly Pro Leu Lys Cys Val Lys Leu Asp Arg Pro Arg Phe Glu Arg Val
 385                 390                 395                 400
 Leu Gly Pro Cys Ser Glu Ile Leu Lys Arg Asn Ile Gln Arg Tyr Asn
                 405                 410                 415    
 Ser Phe Ile Ser Leu Thr Val
             420            



      <210> 2181
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 2181
 Pro Thr Arg Pro Leu Glu Arg Gly Pro Ser Gly Leu Gly Met Gly Leu
   1               5                  10                  15    
 Ile Asp Gly Met His Thr His Leu Gly Ala Pro Gly Leu Tyr Ile Gln
              20                  25                  30        
 Thr Leu Leu Pro Gly Ser Pro Ala Ala Ala Asp Gly Arg Leu Ser Leu
          35                  40                  45            
 Gly Asp Arg Ile Leu Glu Val Asn Gly Ser Ser Leu Leu Gly Leu Gly
      50                  55                  60                
 Tyr Leu Arg Ala Val Asp Leu Ile Arg His Gly Gly Lys Lys Met Arg
  65                  70                  75                  80
 Phe Leu Val Ala Lys Ser Asp Val Glu Thr Ala Lys Lys Ile His Phe
                  85                  90                  95    
 Arg Thr Pro Pro Leu
             100    



      <210> 2182
      <211> 632
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(632)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2182
 Met Gly Lys Tyr Thr Val Arg Val Ala Thr Gly Asp Leu Leu Leu Ala
   1               5                  10                  15    
 Gly Ser Pro Asn Leu Val Gln Leu Trp Leu Val Gly Glu His Gly Glu
              20                  25                  30        
 Ala Asp Leu Gly Lys Gln Leu Pro Pro Val Trp Gly Lys Glu Ala Glu
          35                  40                  45            
 Phe Glu Ile Asp Val Pro Leu His Leu Gly Arg Leu Leu Met Val Lys
      50                  55                  60                
 Leu Arg Lys His Asn Val Leu Leu Ser Leu Asp Trp Phe Cys Lys Trp
  65                  70                  75                  80
 Ile Ser Val Gln Gly Pro Gly Thr Gln Gly Ala Ala Phe Phe Pro Cys
                  85                  90                  95    
 Tyr Arg Trp Val Gln Gly His Gly Ile Ile Cys Leu Pro Glu Gly Thr
             100                 105                 110        
 Arg Trp Gly Ser Trp Lys Asp Gly Leu Ile Leu Pro Ile Ala Gly Asn
         115                 120                 125            
 Arg Gln Pro Asp Leu Pro Arg Asp Glu Arg Phe Leu Glu Asp Lys Asp
     130                 135                 140                
 Leu Asp Phe Asn Val Ser Leu Ala Lys Gly Leu Lys Asp Leu Ala Ile
 145                 150                 155                 160
 Lys Gly Thr Leu Asp Phe Ile Asn Cys Val Lys Arg Leu Glu Asp Phe
                 165                 170                 175    
 Lys Lys Ile Phe Pro His Gly Lys Thr Val Leu Ala Glu Arg Val Tyr
             180                 185                 190        
 Asp Ser Trp Lys Asn Asp Ala Phe Phe Gly Tyr Gln Phe Leu Asn Gly
         195                 200                 205            
 Ala Asn Pro Met Leu Leu Arg Cys Ser Ser Arg Leu Pro Ala Cys Leu
     210                 215                 220                
 Val Leu Pro Pro Gly Met Glu Asp Leu Lys Thr Gln Leu Glu Lys Glu
 225                 230                 235                 240
 Leu Gln Ala Gly Ser Leu Phe Glu Val Asp Phe Ser Leu Leu Asp Gly
                 245                 250                 255    
 Val Lys Pro Asn Val Ile Ile Phe Lys Gln Gln Cys Val Ala Ala Pro
             260                 265                 270        
 Leu Val Val Leu Lys Leu Gln Pro Asp Gly Gly Leu Leu Pro Met Val
         275                 280                 285            
 Ile Gln Leu Gln Pro Pro Xaa His Gly Cys Pro Pro Pro Leu Leu Phe
     290                 295                 300                
 Leu Pro Ser His Pro Pro Met Ala Trp Leu Leu Ala Lys Thr Trp Val
 305                 310                 315                 320
 Arg Ser Ser Asp Phe Gln Leu Gln Gln Leu Gln Ser His Leu Leu Arg
                 325                 330                 335    
 Gly His Leu Ile Ala Glu Val Ile Ala Val Ala Thr Met Arg Ser Leu
             340                 345                 350        
 Pro Ser Leu His Pro Ile Tyr Lys Leu Leu Ile Pro His Phe Arg Tyr
         355                 360                 365            
 Thr Met Ala Ile Asn Thr Leu Ala Gln Ser Ser Leu Val Ser Glu Trp
     370                 375                 380                
 Gly Ile Phe Asp Leu Val Val Ser Thr Gly Ser Gly Ser His Val Asp
 385                 390                 395                 400
 Ile Leu Gln Arg Ala Met Ala Cys Leu Thr Tyr His Ser Leu Cys Pro
                 405                 410                 415    
 Pro Asp Asp Leu Ala Asp Arg Gly Leu Leu Asp Val Lys Ser Ser Phe
             420                 425                 430        
 Tyr Gly Xaa Asp Ala Ile Arg Leu Trp Gly Ile Ile Ser Arg Glu Xaa
         435                 440                 445            
 Tyr Val Glu Gly Met Val Gly Leu Phe Tyr Asn Ser Asp Gln Ala Met
     450                 455                 460                
 Lys Asp Asp Leu Glu Leu Gln Ala Trp Cys Arg Glu Met Thr Glu Thr
 465                 470                 475                 480
 Gly Leu Gln Arg Ala Gln Asp Gln Gly Phe Leu Ile Ser Leu Glu Ser
                 485                 490                 495    
 Arg Ala Gln Leu Cys His Phe Val Thr Met Cys Ile Phe Thr Cys Thr
             500                 505                 510        
 Gly Gln His Ala Ser Asn His Leu Gly Gln Leu Asp Trp Tyr Ser Trp
         515                 520                 525            
 Ile Pro Asn Gly Pro Cys Thr Met Gln Lys Pro Pro Pro Ile Ser Lys
     530                 535                 540                
 Asp Val Thr Glu Lys Asp Ile Val Asp Leu Leu Pro Asn Leu His Gln
 545                 550                 555                 560
 Ala Arg Met Gln Lys Thr Phe Thr Lys Phe Leu Gly Arg Arg Gln Pro
                 565                 570                 575    
 Val Met His Glu Glu Lys Tyr Phe Ser Gly Pro Glu Pro Gln Ala Val
             580                 585                 590        
 Leu Arg Gln Phe Gln Glu Glu Leu Ala Ser Met Asp Lys Glu Ile Glu
         595                 600                 605            
 Val Arg Asn Ala Val Leu Asn Leu Pro Cys Glu Tyr Leu Xaa Pro Ser
     610                 615                 620                
 Met Val Glu Asn Ser Val Thr Ile
 625                 630        



      <210> 2183
      <211> 632
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(632)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2183
 Met Gly Lys Tyr Thr Val Arg Val Ala Thr Gly Asp Leu Leu Leu Ala
   1               5                  10                  15    
 Gly Ser Pro Asn Leu Val Gln Leu Trp Leu Val Gly Glu His Gly Glu
              20                  25                  30        
 Ala Asp Leu Gly Lys Gln Leu Pro Pro Val Trp Gly Lys Glu Ala Glu
          35                  40                  45            
 Phe Glu Ile Asp Val Pro Leu His Leu Gly Arg Leu Leu Met Val Lys
      50                  55                  60                
 Leu Arg Lys His Asn Val Leu Leu Ser Leu Asp Trp Phe Cys Lys Trp
  65                  70                  75                  80
 Ile Ser Val Gln Gly Pro Gly Thr Gln Gly Ala Ala Phe Phe Pro Cys
                  85                  90                  95    
 Tyr Arg Trp Val Gln Gly His Gly Ile Ile Cys Leu Pro Glu Gly Thr
             100                 105                 110        
 Arg Trp Gly Ser Trp Lys Asp Gly Leu Ile Leu Pro Ile Ala Gly Asn
         115                 120                 125            
 Arg Gln Pro Asp Leu Pro Arg Asp Glu Arg Phe Leu Glu Asp Lys Asp
     130                 135                 140                
 Leu Asp Phe Asn Val Ser Leu Ala Lys Gly Leu Lys Asp Leu Ala Ile
 145                 150                 155                 160
 Lys Gly Thr Leu Asp Phe Ile Asn Cys Val Lys Arg Leu Glu Asp Phe
                 165                 170                 175    
 Lys Lys Ile Phe Pro His Gly Lys Thr Val Leu Ala Glu Arg Val Tyr
             180                 185                 190        
 Asp Ser Trp Lys Asn Asp Ala Phe Phe Gly Tyr Gln Phe Leu Asn Gly
         195                 200                 205            
 Ala Asn Pro Met Leu Leu Arg Cys Ser Ser Arg Leu Pro Ala Cys Leu
     210                 215                 220                
 Val Leu Pro Pro Gly Met Glu Asp Leu Lys Thr Gln Leu Glu Lys Glu
 225                 230                 235                 240
 Leu Gln Ala Gly Ser Leu Phe Glu Val Asp Phe Ser Leu Leu Asp Gly
                 245                 250                 255    
 Val Lys Pro Asn Val Ile Ile Phe Lys Gln Gln Cys Val Ala Ala Pro
             260                 265                 270        
 Leu Val Val Leu Lys Leu Gln Pro Asp Gly Gly Leu Leu Pro Met Val
         275                 280                 285            
 Ile Gln Leu Gln Pro Pro Xaa His Gly Cys Pro Pro Pro Leu Leu Phe
     290                 295                 300                
 Leu Pro Ser His Pro Pro Met Ala Trp Leu Leu Ala Lys Thr Trp Val
 305                 310                 315                 320
 Arg Ser Ser Asp Phe Gln Leu Gln Gln Leu Gln Ser His Leu Leu Arg
                 325                 330                 335    
 Gly His Leu Ile Ala Glu Val Ile Ala Val Ala Thr Met Arg Ser Leu
             340                 345                 350        
 Pro Ser Leu His Pro Ile Tyr Lys Leu Leu Ile Pro His Phe Arg Tyr
         355                 360                 365            
 Thr Met Ala Ile Asn Thr Leu Ala Gln Ser Ser Leu Val Ser Glu Trp
     370                 375                 380                
 Gly Ile Phe Asp Leu Val Val Ser Thr Gly Ser Gly Ser His Val Asp
 385                 390                 395                 400
 Ile Leu Gln Arg Ala Met Ala Cys Leu Thr Tyr His Ser Leu Cys Pro
                 405                 410                 415    
 Pro Asp Asp Leu Ala Asp Arg Gly Leu Leu Asp Val Lys Ser Ser Phe
             420                 425                 430        
 Tyr Gly Xaa Asp Ala Ile Arg Leu Trp Gly Ile Ile Ser Arg Glu Xaa
         435                 440                 445            
 Tyr Val Glu Gly Met Val Gly Leu Phe Tyr Asn Ser Asp Gln Ala Met
     450                 455                 460                
 Lys Asp Asp Leu Glu Leu Gln Ala Trp Cys Arg Glu Met Thr Glu Thr
 465                 470                 475                 480
 Gly Leu Gln Arg Ala Gln Asp Gln Gly Phe Leu Ile Ser Leu Glu Ser
                 485                 490                 495    
 Arg Ala Gln Leu Cys His Phe Val Thr Met Cys Ile Phe Thr Cys Thr
             500                 505                 510        
 Gly Gln His Ala Ser Asn His Leu Gly Gln Leu Asp Trp Tyr Ser Trp
         515                 520                 525            
 Ile Pro Asn Gly Pro Cys Thr Met Gln Lys Pro Pro Pro Ile Ser Lys
     530                 535                 540                
 Asp Val Thr Glu Lys Asp Ile Val Asp Leu Leu Pro Asn Leu His Gln
 545                 550                 555                 560
 Ala Arg Met Gln Lys Thr Phe Thr Lys Phe Leu Gly Arg Arg Gln Pro
                 565                 570                 575    
 Val Met His Glu Glu Lys Tyr Phe Ser Gly Pro Glu Pro Gln Ala Val
             580                 585                 590        
 Leu Arg Gln Phe Gln Glu Glu Leu Ala Ser Met Asp Lys Glu Ile Glu
         595                 600                 605            
 Val Arg Asn Ala Val Leu Asn Leu Pro Cys Glu Tyr Leu Xaa Pro Ser
     610                 615                 620                
 Met Val Glu Asn Ser Val Thr Ile
 625                 630        



      <210> 2184
      <211> 632
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(632)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2184
 Met Gly Lys Tyr Thr Val Arg Val Ala Thr Gly Asp Leu Leu Leu Ala
   1               5                  10                  15    
 Gly Ser Pro Asn Leu Val Gln Leu Trp Leu Val Gly Glu His Gly Glu
              20                  25                  30        
 Ala Asp Leu Gly Lys Gln Leu Pro Pro Val Trp Gly Lys Glu Ala Glu
          35                  40                  45            
 Phe Glu Ile Asp Val Pro Leu His Leu Gly Arg Leu Leu Met Val Lys
      50                  55                  60                
 Leu Arg Lys His Asn Val Leu Leu Ser Leu Asp Trp Phe Cys Lys Trp
  65                  70                  75                  80
 Ile Ser Val Gln Gly Pro Gly Thr Gln Gly Ala Ala Phe Phe Pro Cys
                  85                  90                  95    
 Tyr Arg Trp Val Gln Gly His Gly Ile Ile Cys Leu Pro Glu Gly Thr
             100                 105                 110        
 Arg Trp Gly Ser Trp Lys Asp Gly Leu Ile Leu Pro Ile Ala Gly Asn
         115                 120                 125            
 Arg Gln Pro Asp Leu Pro Arg Asp Glu Arg Phe Leu Glu Asp Lys Asp
     130                 135                 140                
 Leu Asp Phe Asn Val Ser Leu Ala Lys Gly Leu Lys Asp Leu Ala Ile
 145                 150                 155                 160
 Lys Gly Thr Leu Asp Phe Ile Asn Cys Val Lys Arg Leu Glu Asp Phe
                 165                 170                 175    
 Lys Lys Ile Phe Pro His Gly Lys Thr Val Leu Ala Glu Arg Val Tyr
             180                 185                 190        
 Asp Ser Trp Lys Asn Asp Ala Phe Phe Gly Tyr Gln Phe Leu Asn Gly
         195                 200                 205            
 Ala Asn Pro Met Leu Leu Arg Cys Ser Ser Arg Leu Pro Ala Cys Leu
     210                 215                 220                
 Val Leu Pro Pro Gly Met Glu Asp Leu Lys Thr Gln Leu Glu Lys Glu
 225                 230                 235                 240
 Leu Gln Ala Gly Ser Leu Phe Glu Val Asp Phe Ser Leu Leu Asp Gly
                 245                 250                 255    
 Val Lys Pro Asn Val Ile Ile Phe Lys Gln Gln Cys Val Ala Ala Pro
             260                 265                 270        
 Leu Val Val Leu Lys Leu Gln Pro Asp Gly Gly Leu Leu Pro Met Val
         275                 280                 285            
 Ile Gln Leu Gln Pro Pro Xaa His Gly Cys Pro Pro Pro Leu Leu Phe
     290                 295                 300                
 Leu Pro Ser His Pro Pro Met Ala Trp Leu Leu Ala Lys Thr Trp Val
 305                 310                 315                 320
 Arg Ser Ser Asp Phe Gln Leu Gln Gln Leu Gln Ser His Leu Leu Arg
                 325                 330                 335    
 Gly His Leu Ile Ala Glu Val Ile Ala Val Ala Thr Met Arg Ser Leu
             340                 345                 350        
 Pro Ser Leu His Pro Ile Tyr Lys Leu Leu Ile Pro His Phe Arg Tyr
         355                 360                 365            
 Thr Met Ala Ile Asn Thr Leu Ala Gln Ser Ser Leu Val Ser Glu Trp
     370                 375                 380                
 Gly Ile Phe Asp Leu Val Val Ser Thr Gly Ser Gly Ser His Val Asp
 385                 390                 395                 400
 Ile Leu Gln Arg Ala Met Ala Cys Leu Thr Tyr His Ser Leu Cys Pro
                 405                 410                 415    
 Pro Asp Asp Leu Ala Asp Arg Gly Leu Leu Asp Val Lys Ser Ser Phe
             420                 425                 430        
 Tyr Gly Xaa Asp Ala Ile Arg Leu Trp Gly Ile Ile Ser Arg Glu Xaa
         435                 440                 445            
 Tyr Val Glu Gly Met Val Gly Leu Phe Tyr Asn Ser Asp Gln Ala Met
     450                 455                 460                
 Lys Asp Asp Leu Glu Leu Gln Ala Trp Cys Arg Glu Met Thr Glu Thr
 465                 470                 475                 480
 Gly Leu Gln Arg Ala Gln Asp Gln Gly Phe Leu Ile Ser Leu Glu Ser
                 485                 490                 495    
 Arg Ala Gln Leu Cys His Phe Val Thr Met Cys Ile Phe Thr Cys Thr
             500                 505                 510        
 Gly Gln His Ala Ser Asn His Leu Gly Gln Leu Asp Trp Tyr Ser Trp
         515                 520                 525            
 Ile Pro Asn Gly Pro Cys Thr Met Gln Lys Pro Pro Pro Ile Ser Lys
     530                 535                 540                
 Asp Val Thr Glu Lys Asp Ile Val Asp Leu Leu Pro Asn Leu His Gln
 545                 550                 555                 560
 Ala Arg Met Gln Lys Thr Phe Thr Lys Phe Leu Gly Arg Arg Gln Pro
                 565                 570                 575    
 Val Met His Glu Glu Lys Tyr Phe Ser Gly Pro Glu Pro Gln Ala Val
             580                 585                 590        
 Leu Arg Gln Phe Gln Glu Glu Leu Ala Ser Met Asp Lys Glu Ile Glu
         595                 600                 605            
 Val Arg Asn Ala Val Leu Asn Leu Pro Cys Glu Tyr Leu Xaa Pro Ser
     610                 615                 620                
 Met Val Glu Asn Ser Val Thr Ile
 625                 630        



      <210> 2185
      <211> 369
      <212> PRT
      <213> Homo sapiens


      <400> 2185
 Met Gly Leu Leu Ile Cys Leu Gly Ala Leu Asp Ala Arg Pro Glu Arg
   1               5                  10                  15    
 Ala Pro Ser Ala Cys Gly Glu Val Trp Arg Glu Arg Arg Gly Arg Glu
              20                  25                  30        
 Pro Gly Leu Pro Thr Val Leu Ala Gly Gln Arg Glu Phe Trp Val Gly
          35                  40                  45            
 Val Gly Ser Ala Ala Leu His Ser Glu Arg Pro Ala Gly Pro Thr Thr
      50                  55                  60                
 Pro Gly Ser Lys Gly Leu Ser Thr Gln Val Ser Ser Cys Gly Gly Arg
  65                  70                  75                  80
 Thr Gly Ser Pro Ser Ser Ala Ser Pro Leu Ala Leu Arg Ser Ile Ser
                  85                  90                  95    
 Arg Trp Gly Leu Ser His Leu Pro His Gly Ala Gly Leu Arg Thr Cys
             100                 105                 110        
 Ser Pro Ala Met Pro Lys Pro Pro His Ser Ala Val Gly Ser Cys Ala
         115                 120                 125            
 Thr Arg Ala Ser Leu Ile Ser Thr Ala Pro Arg Ser Arg Ala Pro Gly
     130                 135                 140                
 Pro Ile Asp His Pro Arg Ala Glu Thr Cys Gln Arg Thr Val Gln Glu
 145                 150                 155                 160
 Leu Ala Gly Ser Ser Thr Cys Ser Pro Val Gln Asp Pro Leu Gly Glu
                 165                 170                 175    
 Ala Ser Trp Ala Pro Glu Phe Glu Gly Ser Gly Pro Lys Arg Arg Ala
             180                 185                 190        
 Asn Gly Arg Gly Ala Tyr Gly Leu Arg Asp Thr Gly Val His Ser Ser
         195                 200                 205            
 Gly Val Ala Ala Arg Ser Pro Ala Ala Ala Glu Arg Trp Val Gln Gly
     210                 215                 220                
 Phe Pro Lys Gln Asn Val His Phe Val Asn Asp Asn Thr Ile Cys Tyr
 225                 230                 235                 240
 Pro Cys Gly Asn Tyr Val Ile Phe Ile Asn Ile Glu Thr Lys Lys Lys
                 245                 250                 255    
 Thr Val Leu Gln Cys Ser Asn Gly Ile Val Gly Val Met Ala Thr Asn
             260                 265                 270        
 Ile Pro Cys Glu Val Val Ala Phe Ser Asp Arg Lys Leu Lys Pro Leu
         275                 280                 285            
 Ile Tyr Val Tyr Ser Phe Pro Gly Leu Thr Arg Arg Thr Lys Leu Lys
     290                 295                 300                
 Ala Asp Gln Glu Arg Asp Pro Phe Leu Tyr Leu Phe Gln Val Ala Glu
 305                 310                 315                 320
 Phe Leu Thr Gln Gly Cys Leu Gln Ile Ser Ala Phe Ser Pro Thr Ser
                 325                 330                 335    
 Gln Arg Tyr Gln Ala Leu Leu Gly Gln Met Trp Asp Leu Ile Arg Gly
             340                 345                 350        
 His Arg Phe Ser Val Glu Lys Ser Val Glu Thr Ser Ser Ser Cys Ser
         355                 360                 365            
 Ala
    



      <210> 2186
      <211> 313
      <212> PRT
      <213> Homo sapiens


      <400> 2186
 Ala Arg Pro Gly Pro Asp Met Ala Ala Leu Tyr Ala Cys Thr Lys Cys
   1               5                  10                  15    
 His Gln Arg Phe Pro Phe Glu Ala Leu Ser Gln Gly Gln Gln Leu Cys
              20                  25                  30        
 Lys Glu Cys Arg Ile Ala His Pro Val Val Lys Cys Thr Tyr Cys Arg
          35                  40                  45            
 Thr Glu Tyr Gln Gln Glu Ser Lys Thr Asn Thr Ile Cys Lys Lys Cys
      50                  55                  60                
 Ala Gln Asn Val Gln Leu Tyr Gly Thr Pro Lys Pro Cys Gln Tyr Cys
  65                  70                  75                  80
 Asn Ile Ile Ala Ala Phe Ile Gly Asn Lys Cys Gln Arg Cys Thr Asn
                  85                  90                  95    
 Ser Glu Lys Lys Tyr Gly Pro Pro Tyr Ser Cys Glu Gln Cys Lys Gln
             100                 105                 110        
 Gln Cys Ala Phe Asp Arg Lys Asp Asp Arg Lys Lys Val Asp Gly Lys
         115                 120                 125            
 Leu Leu Cys Trp Leu Cys Thr Leu Ser Tyr Lys Arg Val Leu Gln Lys
     130                 135                 140                
 Thr Lys Glu Gln Arg Lys His Leu Ser Ser Ser Ser Arg Ala Gly His
 145                 150                 155                 160
 Gln Glu Lys Glu Gln Tyr Ser Arg Leu Ser Gly Gly Gly His Tyr Asn
                 165                 170                 175    
 Ser Gln Lys Thr Leu Ser Thr Ser Ser Ile Gln Asn Glu Ile Pro Lys
             180                 185                 190        
 Lys Lys Ser Lys Phe Glu Ser Ile Thr Thr Asn Gly Asp Ser Phe Ser
         195                 200                 205            
 Pro Asp Leu Ala Leu Asp Ser Pro Gly Thr Asp His Phe Val Ile Ile
     210                 215                 220                
 Ala Gln Leu Lys Glu Glu Val Ala Thr Leu Lys Lys Met Leu His Gln
 225                 230                 235                 240
 Lys Asp Gln Met Ile Leu Glu Lys Glu Lys Lys Ile Thr Glu Leu Lys
                 245                 250                 255    
 Ala Asp Phe Gln Tyr Gln Glu Ser Gln Met Arg Ala Lys Met Asn Gln
             260                 265                 270        
 Met Glu Lys Thr His Lys Glu Val Thr Glu Gln Leu Gln Ala Lys Asn
         275                 280                 285            
 Arg Glu Leu Leu Lys Gln Ala Ala Ala Leu Ser Lys Ser Lys Lys Ser
     290                 295                 300                
 Glu Lys Ser Gly Ala Ile Thr Ser Pro
 305                 310            



      <210> 2187
      <211> 66
      <212> PRT
      <213> Homo sapiens


      <400> 2187
 Arg Ser Gly Arg Thr Val Val Thr Gly Ile Gly Tyr Ser Lys Ala Leu
   1               5                  10                  15    
 Gln Ser Ser Asn Arg Asn Thr Lys Ser Leu Leu Gln Asn Glu Phe Met
              20                  25                  30        
 Met Val Tyr Ser Phe Arg Ala Leu Ser Phe Lys Glu Ser Thr Trp Ala
          35                  40                  45            
 Thr Phe Gln His Gly Gly Glu Ala Thr Lys Ser Arg Ser Leu Ser Ser
      50                  55                  60                
 Thr Gln
  65    



      <210> 2188
      <211> 66
      <212> PRT
      <213> Homo sapiens


      <400> 2188
 Arg Ser Gly Arg Thr Val Val Thr Gly Ile Gly Tyr Ser Lys Ala Leu
   1               5                  10                  15    
 Gln Ser Ser Asn Arg Asn Thr Lys Ser Leu Leu Gln Asn Glu Phe Met
              20                  25                  30        
 Met Val Tyr Ser Phe Arg Ala Leu Ser Phe Lys Glu Ser Thr Trp Ala
          35                  40                  45            
 Thr Phe Gln His Gly Gly Glu Ala Thr Lys Ser Arg Ser Leu Ser Ser
      50                  55                  60                
 Thr Gln
  65    



      <210> 2189
      <211> 66
      <212> PRT
      <213> Homo sapiens


      <400> 2189
 Arg Ser Gly Arg Thr Val Val Thr Gly Ile Gly Tyr Ser Lys Ala Leu
   1               5                  10                  15    
 Gln Ser Ser Asn Arg Asn Thr Lys Ser Leu Leu Gln Asn Glu Phe Met
              20                  25                  30        
 Met Val Tyr Ser Phe Arg Ala Leu Ser Phe Lys Glu Ser Thr Trp Ala
          35                  40                  45            
 Thr Phe Gln His Gly Gly Glu Ala Thr Lys Ser Arg Ser Leu Ser Ser
      50                  55                  60                
 Thr Gln
  65    



      <210> 2190
      <211> 66
      <212> PRT
      <213> Homo sapiens


      <400> 2190
 Arg Ser Gly Arg Thr Val Val Thr Gly Ile Gly Tyr Ser Lys Ala Leu
   1               5                  10                  15    
 Gln Ser Ser Asn Arg Asn Thr Lys Ser Leu Leu Gln Asn Glu Phe Met
              20                  25                  30        
 Met Val Tyr Ser Phe Arg Ala Leu Ser Phe Lys Glu Ser Thr Trp Ala
          35                  40                  45            
 Thr Phe Gln His Gly Gly Glu Ala Thr Lys Ser Arg Ser Leu Ser Ser
      50                  55                  60                
 Thr Gln
  65    



      <210> 2191
      <211> 66
      <212> PRT
      <213> Homo sapiens


      <400> 2191
 Arg Ser Gly Arg Thr Val Val Thr Gly Ile Gly Tyr Ser Lys Ala Leu
   1               5                  10                  15    
 Gln Ser Ser Asn Arg Asn Thr Lys Ser Leu Leu Gln Asn Glu Phe Met
              20                  25                  30        
 Met Val Tyr Ser Phe Arg Ala Leu Ser Phe Lys Glu Ser Thr Trp Ala
          35                  40                  45            
 Thr Phe Gln His Gly Gly Glu Ala Thr Lys Ser Arg Ser Leu Ser Ser
      50                  55                  60                
 Thr Gln
  65    



      <210> 2192
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 2192
 Arg Arg Asn Ser Pro Gly Leu Cys Phe Leu Leu Pro Ser Leu Phe His
   1               5                  10                  15    
 Leu Arg Leu Leu Trp Arg Leu Leu Leu Trp His Gln Val Phe Phe Asp
              20                  25                  30        
 Val Ala Ile Phe Val Ile Gly Gly Ile Cys Ser Val Ser Gly Phe Val
          35                  40                  45            
 His Ser Leu Glu Gly Leu Ile Glu Ala Tyr Arg Thr Asn Ala Glu Asp
      50                  55                  60                





      <210> 2193
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 2193
 Met Pro Ser Gly Cys Arg Cys Leu His Leu Val Cys Leu Leu Cys Ile
   1               5                  10                  15    
 Leu Gly Ala Pro Gly Gln Pro Val Arg Ala Asp Asp Cys Ser Ser His
              20                  25                  30        
 Cys Asp Leu Ala His Gly Cys Cys Ala Pro Asp Gly Ser Cys Arg Cys
          35                  40                  45            
 Asp Pro Gly Trp Glu Gly Leu His Cys Glu Arg Cys Val Arg Met Pro
      50                  55                  60                
 Gly Cys Gln His Gly Thr Cys His Gln Pro Trp Gln Cys Ile Cys His
  65                  70                  75                  80
 Ser Gly Trp Ala Gly Lys Phe Cys Asp Lys Asp Glu His Ile Cys Thr
                  85                  90                  95    
 Thr Gln Ser Pro Cys Gln Asn Gly Gly Gln Cys Met Tyr Asp Gly Gly
             100                 105                 110        
 Gly Glu Tyr His Cys Val Cys Leu Pro Gly Phe His Gly Arg Asp Cys
         115                 120                 125            
 Glu Arg Lys Ala Gly Pro Cys Glu Gln Ala Gly Ser Pro Cys Arg Asn
     130                 135                 140                
 Gly Gly Gln Cys Gln Asp Asp Gln Gly Phe Ala Leu Asn Phe Thr Cys
 145                 150                 155                 160
 Arg Cys Leu Val Gly Phe Val Gly Ala Arg Cys Asp Val
                 165                 170            



      <210> 2194
      <211> 469
      <212> PRT
      <213> Homo sapiens


      <400> 2194
 Asn Val Val Ser Arg Ala Pro Pro Ala Pro Val Glu Asp Leu Ser Lys
   1               5                  10                  15    
 Val Ser Tyr Glu Glu Leu Leu Gln Trp Ser Lys Glu Glu Leu Ile Arg
              20                  25                  30        
 Ser Leu Arg Arg Ala Glu Ala Glu Lys Val Ser Ala Met Leu Asp His
          35                  40                  45            
 Ser Asn Leu Ile Arg Glu Val Asn Arg Arg Leu Gln Leu His Leu Gly
      50                  55                  60                
 Glu Ile Arg Gly Leu Lys Asp Ile Asn Gln Lys Leu Gln Glu Asp Asn
  65                  70                  75                  80
 Gln Glu Leu Arg Asp Leu Cys Cys Phe Leu Asp Asp Asp Arg Gln Lys
                  85                  90                  95    
 Gly Lys Arg Val Ser Arg Glu Trp Gln Arg Leu Gly Arg Tyr Thr Ala
             100                 105                 110        
 Gly Val Met His Lys Glu Val Ala Leu Tyr Leu Gln Lys Leu Lys Asp
         115                 120                 125            
 Leu Glu Val Lys Gln Glu Glu Val Val Lys Glu Asn Met Glu Leu Lys
     130                 135                 140                
 Glu Leu Cys Val Leu Leu Asp Glu Glu Lys Gly Ala Gly Ser Gln Ala
 145                 150                 155                 160
 Ala Ala Ala Pro Ser Thr Ala Arg Pro Ala Cys Ala Asn Ser Gln Pro
                 165                 170                 175    
 Pro Thr Ala Pro Tyr Val Arg Asp Val Gly Asp Gly Ser Ser Thr Ser
             180                 185                 190        
 Ser Thr Gly Ser Thr Asp Ser Pro Asp His His Lys His His Ala Ser
         195                 200                 205            
 Ser Gly Ser Pro Glu His Leu Gln Lys Pro Arg Ser Glu Gly Ser Pro
     210                 215                 220                
 Glu His Ser Lys His Arg Ser Ala Ser Pro Glu His Pro Gln Lys Pro
 225                 230                 235                 240
 Arg Ala Cys Gly Thr Pro Asp Arg Pro Lys Ala Leu Lys Gly Pro Ser
                 245                 250                 255    
 Pro Glu His His Lys Pro Leu Cys Lys Gly Ser Pro Glu Gln Gln Arg
             260                 265                 270        
 His Pro His Pro Gly Ser Ser Pro Glu Thr Leu Pro Lys His Val Leu
         275                 280                 285            
 Ser Gly Ser Pro Glu His Phe Gln Lys His Arg Ser Gly Ser Ser Pro
     290                 295                 300                
 Glu His Ala Arg His Ser Gly Gly Ser Pro Glu His Leu Gln Lys His
 305                 310                 315                 320
 Ala Leu Gly Gly Ser Leu Glu His Leu Pro Arg Ala Arg Gly Thr Ser
                 325                 330                 335    
 Pro Glu His Leu Lys Gln His Tyr Gly Gly Ser Pro Asp His Lys His
             340                 345                 350        
 Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Ser Arg Glu
         355                 360                 365            
 Gly Thr Leu Arg Arg Gln Ala Gln Glu Asp Gly Ser Pro His His Arg
     370                 375                 380                
 Asn Val Tyr Ser Gly Met Asn Glu Ser Thr Leu Ser Tyr Val Arg Gln
 385                 390                 395                 400
 Leu Glu Ala Arg Val Arg Gln Leu Glu Glu Glu Asn Arg Met Leu Pro
                 405                 410                 415    
 Gln Ala Ser Gln Asn Thr Gly Arg Pro Pro Thr Lys Asn Ser Ser His
             420                 425                 430        
 Met Glu Lys Gly Trp Gly Ser Arg Ala Arg Arg Val Leu His Trp Trp
         435                 440                 445            
 Gln Gly Cys Arg Gly Ile Gly Arg Cys Leu Ala Thr Leu Thr Gly Ser
     450                 455                 460                
 Phe Arg Trp Ser Ser
 465                



      <210> 2195
      <211> 420
      <212> PRT
      <213> Homo sapiens


      <400> 2195
 Gly Val Thr His Leu Phe Leu Phe Gly Lys Arg Lys Leu Arg Asn Gly
   1               5                  10                  15    
 Ile Ala Glu Asp Leu Lys Gly Gln Ala Asp Phe Phe Phe Leu Leu Val
              20                  25                  30        
 Ser Glu Ala Val Val Ala Thr Gly Ser Pro Arg Ala Trp Leu Thr Cys
          35                  40                  45            
 Leu Ile Leu Pro Leu Pro Gly Ile Ile Phe Ser Val Leu Pro Lys Ala
      50                  55                  60                
 Met Ser Arg Pro Leu Leu Ile Thr Phe Thr Pro Ala Thr Asp Pro Ser
  65                  70                  75                  80
 Asp Leu Trp Lys Asp Gly Gln Gln Gln Pro Gln Pro Glu Lys Pro Glu
                  85                  90                  95    
 Ser Thr Leu Asp Gly Ala Ala Ala Arg Ala Phe Tyr Glu Ala Leu Ile
             100                 105                 110        
 Gly Asp Glu Ser Ser Ala Pro Asp Ser Gln Arg Ser Gln Thr Glu Pro
         115                 120                 125            
 Ala Arg Glu Arg Lys Arg Lys Lys Arg Arg Ile Met Lys Ala Pro Ala
     130                 135                 140                
 Ala Glu Ala Val Ala Glu Gly Ala Ser Gly Arg His Gly Gln Gly Arg
 145                 150                 155                 160
 Ser Leu Glu Ala Glu Asp Lys Met Thr His Arg Ile Leu Arg Ala Ala
                 165                 170                 175    
 Gln Glu Gly Asp Leu Pro Glu Leu Arg Arg Leu Leu Glu Pro His Glu
             180                 185                 190        
 Ala Gly Gly Ala Gly Gly Asn Ile Asn Ala Arg Asp Ala Phe Trp Trp
         195                 200                 205            
 Thr Pro Leu Met Cys Ala Ala Arg Ala Gly Gln Gly Ala Ala Val Ser
     210                 215                 220                
 Tyr Leu Leu Gly Arg Gly Ala Ala Trp Val Gly Val Cys Glu Leu Ser
 225                 230                 235                 240
 Gly Arg Asp Ala Ala Gln Leu Ala Glu Glu Ala Gly Phe Pro Glu Val
                 245                 250                 255    
 Ala Arg Met Val Arg Glu Ser His Gly Glu Thr Arg Ser Pro Glu Asn
             260                 265                 270        
 Arg Ser Pro Thr Pro Ser Leu Gln Tyr Cys Glu Asn Cys Asp Thr His
         275                 280                 285            
 Phe Gln Asp Ser Asn His Arg Thr Ser Thr Ala His Leu Leu Ser Leu
     290                 295                 300                
 Ser Gln Gly Pro Gln Pro Pro Asn Leu Pro Leu Gly Val Pro Ile Ser
 305                 310                 315                 320
 Ser Pro Gly Phe Lys Leu Leu Leu Arg Gly Gly Trp Glu Pro Gly Met
                 325                 330                 335    
 Gly Leu Gly Pro Arg Gly Glu Gly Arg Ala Asn Pro Ile Pro Thr Val
             340                 345                 350        
 Leu Lys Arg Asp Gln Glu Gly Leu Gly Tyr Arg Ser Ala Pro Gln Pro
         355                 360                 365            
 Arg Val Thr His Phe Pro Ala Trp Asp Thr Arg Ala Val Ala Gly Arg
     370                 375                 380                
 Glu Thr Pro Pro Arg Val Ala Thr Leu Ser Trp Arg Glu Glu Arg Arg
 385                 390                 395                 400
 Arg Glu Glu Lys Asp Arg Ala Trp Glu Arg Asp Leu Arg Thr Tyr Met
                 405                 410                 415    
 Asn Leu Glu Phe
             420



      <210> 2196
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 2196
 Ser Phe Ala Gly Ala Ala Ala Arg Pro Ser Thr Pro Pro Ala Ser Gly
   1               5                  10                  15    
 Arg Gly Ala Ala Pro Gly Arg Pro Gly Pro Ser Pro Met Asp Leu Arg
              20                  25                  30        
 Ala Gly Asp Ser Trp Gly Met Leu Ala Cys Leu Cys Thr Val Leu Trp
          35                  40                  45            
 His Leu Pro Ala Val Pro Ala Leu Asn Arg Thr Gly Asp Pro Gly Pro
      50                  55                  60                
 Gly Pro Ser Ile Gln Lys Thr Tyr Asp Leu Thr Arg Tyr Leu Glu His
  65                  70                  75                  80
 Gln Leu Arg Ser Leu Ala Gly Thr Tyr Leu Asn Tyr Leu Gly Pro Pro
                  85                  90                  95    
 Phe Asn Glu Pro Asp Phe Asn Pro Pro Arg Leu Gly Ala Glu Thr Leu
             100                 105                 110        
 Pro Arg Ala Thr Val Asp Leu Glu Val Trp Arg Ser Leu Asn Asp Lys
         115                 120                 125            
 Leu Arg Leu Thr Gln Asn Tyr Glu Ala Tyr Ser His Leu Leu Cys Tyr
     130                 135                 140                
 Leu Arg Gly Leu Asn Arg Gln Ala Ala Thr Ala Glu Leu Arg Arg Ser
 145                 150                 155                 160
 Leu Ala His Phe Cys Thr Ser Leu Gln Gly Leu Leu Gly Ser Ile Ala
                 165                 170                 175    
 Gly Val Met Ala Ala Leu Gly Tyr Pro Leu Pro Gln Pro Leu Pro Gly
             180                 185                 190        
 Thr Glu Pro Thr Trp Thr Pro Gly Pro Ala His Ser Asp Phe Leu Gln
         195                 200                 205            
 Lys Met Asp Asp Phe Trp Leu Leu Lys Glu Leu Gln Thr Trp Leu Trp
     210                 215                 220                
 Arg Ser Ala Lys Asp Phe Asn Arg Leu Lys Lys Lys Met Gln Pro Pro
 225                 230                 235                 240
 Ala Ala Ala Val Thr Leu His Leu Gly Ala His Gly Phe
                 245                 250            



      <210> 2197
      <211> 351
      <212> PRT
      <213> Homo sapiens


      <400> 2197
 Pro Pro Ile Ala Arg Leu Gln Glu Phe Gly Thr Ser Arg Arg His Met
   1               5                  10                  15    
 Ala Ala Pro Ser Gly Val His Leu Leu Val Arg Arg Gly Ser His Arg
              20                  25                  30        
 Ile Phe Ser Ser Pro Leu Asn His Ile Tyr Leu His Lys Gln Ser Ser
          35                  40                  45            
 Ser Gln Gln Arg Arg Asn Phe Phe Phe Arg Arg Gln Arg Asp Ile Ser
      50                  55                  60                
 His Ser Ile Val Leu Pro Ala Ala Val Ser Ser Ala His Pro Val Pro
  65                  70                  75                  80
 Lys His Ile Lys Lys Pro Asp Tyr Val Thr Thr Gly Ile Val Pro Asp
                  85                  90                  95    
 Trp Gly Asp Ser Ile Glu Val Lys Asn Glu Asp Gln Ile Gln Gly Leu
             100                 105                 110        
 His Gln Ala Cys Gln Leu Ala Arg His Val Leu Leu Leu Ala Gly Lys
         115                 120                 125            
 Ser Leu Lys Val Asp Met Thr Thr Glu Glu Ile Asp Ala Leu Val His
     130                 135                 140                
 Arg Glu Ile Ile Ser His Asn Ala Tyr Pro Ser Pro Leu Gly Tyr Gly
 145                 150                 155                 160
 Gly Phe Pro Lys Ser Val Cys Thr Ser Val Asn Asn Val Leu Cys His
                 165                 170                 175    
 Gly Ile Pro Asp Ser Arg Pro Leu Gln Asp Gly Asp Ile Ile Asn Ile
             180                 185                 190        
 Asp Val Thr Val Tyr Tyr Asn Gly Tyr His Gly Asp Thr Ser Glu Thr
         195                 200                 205            
 Phe Leu Val Gly Asn Val Asp Glu Cys Gly Lys Lys Leu Val Glu Val
     210                 215                 220                
 Ala Arg Arg Cys Arg Asp Glu Ala Ile Ala Ala Cys Arg Ala Gly Ala
 225                 230                 235                 240
 Pro Phe Ser Val Ile Gly Asn Thr Ile Ser His Ile Thr His Gln Asn
                 245                 250                 255    
 Gly Phe Gln Val Cys Pro His Phe Val Gly His Gly Ile Gly Ser Tyr
             260                 265                 270        
 Phe His Gly His Pro Glu Ile Trp His His Ala Asn Asp Ser Asp Leu
         275                 280                 285            
 Pro Met Glu Glu Gly Met Ala Phe Thr Ile Glu Pro Ile Ile Thr Glu
     290                 295                 300                
 Gly Ser Pro Glu Phe Lys Val Leu Glu Asp Ala Trp Thr Val Val Ser
 305                 310                 315                 320
 Leu Asp Thr Ser Lys Val Ser Ala Gln Phe Glu His Thr Val Leu Ile
                 325                 330                 335    
 Thr Ser Arg Gly Ala Gln Ile Leu Thr Lys Leu Pro His Glu Ala
             340                 345                 350    



      <210> 2198
      <211> 454
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(454)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2198
 Ser Pro Gly Thr Pro Ala Ala Gly Arg Thr Ser Arg Thr Val Gln Thr
   1               5                  10                  15    
 Pro Phe Xaa Ser Arg Thr Pro Leu Ala Leu Met Ile Gly Ser Glu Asn
              20                  25                  30        
 Trp Pro Gly Leu Gln Phe Pro Ala Lys Trp Ala Pro Xaa Ala Asn His
          35                  40                  45            
 Leu Thr Phe Ala Gly Leu Thr Pro Asn His Ser Gly Thr Lys Trp Ala
      50                  55                  60                
 Gly Ile Ser Gly Thr Arg Leu Ser Leu Pro Gly Ala Gly Ala Ala Ala
  65                  70                  75                  80
 Pro Glu Val Pro Arg Arg Cys Arg Arg His Cys Pro Glu Cys Leu Gln
                  85                  90                  95    
 Pro Ala Gly Asn Ala Ala Pro Glu Gln Ser Gly Gly Cys Arg Leu Ala
             100                 105                 110        
 Phe Leu Xaa Ala Arg Ser Thr Ser Ser Arg Ala Arg Gly Leu Leu Gly
         115                 120                 125            
 Ser Glu Val Arg Arg Pro Gly Val Ala Gly Ser Gln Arg Ala Lys Leu
     130                 135                 140                
 Leu Thr Pro Xaa Leu Pro Phe Leu Leu Gly Val Ser Ser Pro Ser Pro
 145                 150                 155                 160
 Lys Ser Gly Ser Arg Thr Ala Ala Met His Gln Pro Arg Leu Ser Ser
                 165                 170                 175    
 Pro Ile Gln Arg Arg Arg Lys Cys Ser Gly Glu Arg Glu Ala Ser His
             180                 185                 190        
 Tyr Glu Pro Ala Leu Ser Lys Ala Val Arg Ser Val Gly Gly Ser Pro
         195                 200                 205            
 Lys Ser Ala Ser Gly Asp Ala Gly Arg Ala Arg Ser Ser Arg Ala Pro
     210                 215                 220                
 Asn Ser Glu Ser Ser Asn Met Ala Ala Arg Leu Ala Ile Glu Arg Glu
 225                 230                 235                 240
 Glu Lys Ala Gly Asp Xaa Gln Ala Ala Arg Arg Arg Arg Gly Pro Pro
                 245                 250                 255    
 Pro Pro Phe Thr Ser Gly Ile Xaa Ser Arg Leu Pro Glu Ala Gly Thr
             260                 265                 270        
 Met Ser Ala Xaa Gln Pro Thr Leu Glu Phe Gly Gly Ser Leu Pro Xaa
         275                 280                 285            
 Ser Lys Gly Asn Ser Ser His Ser Lys Glu Leu Glu Ala Ser Pro Ser
     290                 295                 300                
 Val Val Gly Arg Gln Pro Gly Ala Val Ser Gly Asn Cys Gly Met Cys
 305                 310                 315                 320
 Pro Trp Gly Pro Glu Lys Thr Glu Gly Arg Cys Ser Arg Pro Val Thr
                 325                 330                 335    
 Thr Ala Trp Cys Ser Leu Cys Ser Ser Cys Cys Cys Pro Met Thr Ser
             340                 345                 350        
 Leu Ser Ile Pro Ser Gln Asn Cys Ser Lys Arg Leu Leu Ser Ser Ser
         355                 360                 365            
 Leu Cys Ser Ser Ser Ser Arg Ile Leu Gln Ser Ser Ser Thr Ser Ser
     370                 375                 380                
 Ser Phe Ser Ser Cys Ser Ser Thr Pro Ser Ser Ser Arg Leu Ala Trp
 385                 390                 395                 400
 Ser Thr Ser Tyr Ser Ile Ser Ser Lys Gly Pro Ser Ser Xaa Gln Leu
                 405                 410                 415    
 Cys Thr Leu Pro Ser Ala Ser Pro Phe Met Ser Gly Ser Xaa Thr Tyr
             420                 425                 430        
 Ala Gly Lys Thr Pro Thr Ala Ser Tyr Gly Gln Met Asp Phe Lys Cys
         435                 440                 445            
 Cys Leu Tyr Ser Arg Asp
     450                



      <210> 2199
      <211> 1115
      <212> PRT
      <213> Homo sapiens


      <400> 2199
 Met Asp Gln Pro Glu Ala Pro Cys Ser Ser Thr Gly Pro Arg Leu Ala
   1               5                  10                  15    
 Val Ala Arg Glu Leu Leu Leu Ala Ala Leu Glu Glu Leu Ser Gln Glu
              20                  25                  30        
 Gln Leu Lys Arg Phe Arg His Lys Leu Arg Asp Val Gly Pro Asp Gly
          35                  40                  45            
 Arg Ser Ile Pro Trp Gly Arg Leu Glu Arg Ala Asp Ala Val Asp Leu
      50                  55                  60                
 Ala Glu Gln Leu Ala Gln Phe Tyr Gly Pro Glu Pro Ala Leu Glu Val
  65                  70                  75                  80
 Ala Arg Lys Thr Leu Lys Arg Ala Asp Ala Arg Asp Val Ala Ala Gln
                  85                  90                  95    
 Leu Gln Glu Arg Arg Leu Gln Arg Leu Gly Leu Gly Ser Gly Thr Leu
             100                 105                 110        
 Leu Ser Val Ser Glu Tyr Lys Lys Lys Tyr Arg Glu His Val Leu Gln
         115                 120                 125            
 Leu His Ala Arg Val Lys Glu Arg Asn Ala Arg Ser Val Lys Ile Thr
     130                 135                 140                
 Lys Arg Phe Thr Lys Leu Leu Ile Ala Pro Glu Ser Ala Ala Pro Glu
 145                 150                 155                 160
 Glu Ala Leu Gly Pro Ala Glu Glu Pro Glu Pro Gly Arg Ala Arg Arg
                 165                 170                 175    
 Ser Asp Thr His Thr Phe Asn Arg Leu Phe Arg Arg Asp Glu Glu Gly
             180                 185                 190        
 Arg Arg Pro Leu Thr Val Val Leu Gln Gly Pro Ala Gly Ile Gly Lys
         195                 200                 205            
 Thr Met Ala Ala Lys Lys Ile Leu Tyr Asp Trp Ala Ala Gly Lys Leu
     210                 215                 220                
 Tyr Gln Gly Gln Val Asp Phe Ala Phe Phe Met Pro Cys Gly Glu Leu
 225                 230                 235                 240
 Leu Glu Arg Pro Gly Thr Arg Ser Leu Ala Asp Leu Ile Leu Asp Gln
                 245                 250                 255    
 Cys Pro Asp Arg Gly Ala Pro Val Pro Gln Met Leu Ala Gln Pro Gln
             260                 265                 270        
 Arg Leu Leu Phe Ile Leu Asp Gly Ala Asp Glu Leu Pro Ala Leu Gly
         275                 280                 285            
 Gly Pro Glu Ala Ala Pro Cys Thr Asp Pro Phe Glu Ala Ala Ser Gly
     290                 295                 300                
 Ala Arg Val Leu Gly Gly Leu Leu Ser Lys Ala Leu Leu Pro Thr Ala
 305                 310                 315                 320
 Leu Leu Leu Val Thr Thr Arg Ala Ala Ala Pro Gly Arg Leu Gln Gly
                 325                 330                 335    
 Arg Leu Cys Ser Pro Gln Cys Ala Glu Val Arg Gly Phe Ser Asp Lys
             340                 345                 350        
 Asp Lys Lys Lys Tyr Phe Tyr Lys Phe Phe Arg Asp Glu Arg Arg Ala
         355                 360                 365            
 Glu Arg Ala Tyr Arg Phe Val Lys Glu Asn Glu Thr Leu Phe Ala Leu
     370                 375                 380                
 Cys Phe Val Pro Phe Val Cys Trp Ile Val Cys Thr Val Leu Arg Gln
 385                 390                 395                 400
 Gln Leu Glu Leu Gly Arg Asp Leu Ser Arg Thr Ser Lys Thr Thr Thr
                 405                 410                 415    
 Ser Val Tyr Leu Leu Phe Ile Thr Ser Val Leu Ser Ser Ala Pro Val
             420                 425                 430        
 Ala Asp Gly Pro Arg Leu Gln Gly Asp Leu Arg Asn Leu Cys Arg Leu
         435                 440                 445            
 Ala Arg Glu Gly Val Leu Gly Arg Arg Ala Gln Phe Ala Glu Lys Glu
     450                 455                 460                
 Leu Glu Gln Leu Glu Leu Arg Gly Ser Lys Val Gln Thr Leu Phe Leu
 465                 470                 475                 480
 Ser Lys Lys Glu Leu Pro Gly Val Leu Glu Thr Glu Val Thr Tyr Gln
                 485                 490                 495    
 Phe Ile Asp Gln Ser Phe Gln Glu Phe Leu Ala Ala Leu Ser Tyr Leu
             500                 505                 510        
 Leu Glu Asp Gly Gly Val Pro Arg Thr Ala Ala Gly Gly Val Gly Thr
         515                 520                 525            
 Leu Leu Arg Gly Asp Ala Gln Pro His Ser His Leu Val Leu Thr Thr
     530                 535                 540                
 Arg Phe Leu Phe Gly Leu Leu Ser Ala Glu Arg Met Arg Asp Ile Glu
 545                 550                 555                 560
 Arg His Phe Gly Cys Met Val Ser Glu Arg Val Lys Gln Glu Ala Leu
                 565                 570                 575    
 Arg Trp Val Gln Gly Gln Gly Gln Gly Cys Pro Gly Val Ala Pro Glu
             580                 585                 590        
 Val Thr Glu Gly Ala Lys Gly Leu Glu Asp Thr Glu Glu Pro Glu Glu
         595                 600                 605            
 Glu Glu Glu Gly Glu Glu Pro Asn Tyr Pro Leu Glu Leu Leu Tyr Cys
     610                 615                 620                
 Leu Tyr Glu Thr Gln Glu Asp Ala Phe Val Arg Gln Ala Leu Cys Arg
 625                 630                 635                 640
 Phe Pro Glu Leu Ala Leu Gln Arg Val Arg Phe Cys Arg Met Asp Val
                 645                 650                 655    
 Ala Val Leu Ser Tyr Cys Val Arg Cys Cys Pro Ala Gly Gln Ala Leu
             660                 665                 670        
 Arg Leu Ile Ser Cys Arg Leu Val Ala Ala Gln Glu Lys Lys Lys Lys
         675                 680                 685            
 Ser Leu Gly Lys Arg Leu Gln Ala Arg Leu Gly Gly Gly Ser Trp Leu
     690                 695                 700                
 Gly Thr Gln Leu Ala Pro Glu Val Pro Phe Arg Pro Pro Cys Cys Asp
 705                 710                 715                 720
 Ile Cys Pro Thr Pro Pro Pro Asp Pro Arg Leu Leu Gln Gly Lys Ala
                 725                 730                 735    
 Phe Ala Arg Val Pro Leu Asn Ile Ala Pro Ile Gln Pro Leu Pro Arg
             740                 745                 750        
 Gly Leu Ala Ser Val Glu Arg Met Asn Val Thr Val Leu Ala Gly Ala
         755                 760                 765            
 Gly Pro Gly Asp Pro Lys Thr His Ala Met Thr Asp Pro Leu Cys His
     770                 775                 780                
 Leu Ser Ser Leu Thr Leu Ser His Cys Lys Leu Pro Asp Ala Val Cys
 785                 790                 795                 800
 Arg Asp Leu Ser Glu Ala Leu Arg Ala Ala Pro Ala Leu Thr Glu Leu
                 805                 810                 815    
 Gly Leu Leu His Asn Arg Leu Ser Glu Ala Gly Leu Arg Met Leu Ser
             820                 825                 830        
 Glu Gly Leu Ala Trp Pro Gln Cys Arg Val Gln Thr Val Arg Val Gln
         835                 840                 845            
 Leu Pro Asp Pro Gln Arg Gly Leu Gln Tyr Leu Val Gly Met Leu Arg
     850                 855                 860                
 Gln Ser Pro Ala Leu Thr Thr Leu Asp Leu Ser Gly Cys Gln Leu Pro
 865                 870                 875                 880
 Ala Pro Met Val Thr Tyr Leu Cys Ala Val Leu Gln His Gln Gly Cys
                 885                 890                 895    
 Gly Leu Gln Thr Leu Ser Leu Ser Leu Pro Ser Asp Pro Thr Pro Ser
             900                 905                 910        
 Ser Phe Ser Gly Arg Cys Arg Glu Pro Gly Arg Arg Leu Gly Leu Glu
         915                 920                 925            
 Ser Arg Trp Pro Arg Ser Ala Pro Glu Pro Ser Gly Arg Gln Arg Gly
     930                 935                 940                
 Glu Asp Pro Gly Gly Gly Gly Arg Gly Arg Gly Arg Arg Glu Glu Ala
 945                 950                 955                 960
 Arg Glu Gly Thr Pro Gly Pro Arg Ala Pro Pro Thr Ala Ala Pro Gly
                 965                 970                 975    
 Arg Ser Ser Gly Ser Arg Leu Glu Leu Cys Ser Leu Arg Ala Leu Arg
             980                 985                 990        
 Ala Gly Asn Ala Arg Pro Pro Asp Ala Thr His Ala Ala Ala Ala Ser
         995                1000                1005            
 Gly Asp Arg Gly Glu Pro Gly Pro Arg Pro Arg Val His Val Pro Pro
    1010                1015                1020                
 Pro Gly Pro Ala Gln Arg Pro Pro Pro Pro Pro Arg Asp Arg Pro Arg
1025                1030                1035                1040
 Leu Pro Ala Thr Ala Arg Ala Leu Gly Ala Gly Thr Ala Asp Leu Pro
                1045                1050                1055    
 Gly Gly Ala Ala Ala Gly Arg Leu Leu Leu Pro Pro Gly Pro Gly Val
            1060                1065                1070        
 Glu Gln Arg Asp Thr Gly Ser His Ala Gly Ala Arg Arg Pro Gly Gly
        1075                1080                1085            
 Ala Ala Ala Ala Gln Ala Gln Gln Leu His Gly Gly Arg Arg Arg Gly
    1090                1095                1100                
 Pro His His Val Cys Cys Pro Leu Ser Ala Gln
1105                1110                1115



      <210> 2200
      <211> 143
      <212> PRT
      <213> Homo sapiens


      <400> 2200
 Gly Ile Arg Cys Arg Phe Gly Thr Ser Glu Ile Arg Ala His Ala Thr
   1               5                  10                  15    
 Ala Lys Ala Thr Val Ala Ala Phe Thr Ala Ser Glu Gly His Ala His
              20                  25                  30        
 Pro Arg Val Val Glu Leu Pro Lys Thr Asp Glu Gly Leu Gly Phe Asn
          35                  40                  45            
 Ile Met Gly Gly Lys Glu Gln Asn Ser Pro Ile Tyr Ile Ser Arg Val
      50                  55                  60                
 Ile Pro Gly Gly Val Ala Asp Arg His Gly Gly Leu Lys Arg Gly Asp
  65                  70                  75                  80
 Gln Leu Leu Ser Val Asn Gly Val Ser Val Glu Gly Glu Gln His Glu
                  85                  90                  95    
 Lys Ala Val Glu Leu Leu Lys Ala Ala Gln Gly Ser Val Lys Leu Val
             100                 105                 110        
 Val Arg Tyr Thr Pro Arg Val Leu Glu Glu Met Glu Ala Arg Phe Glu
         115                 120                 125            
 Lys Met Arg Ser Ala Arg Arg Arg Gln Gln His Gln Ser Tyr Ser
     130                 135                 140            



      <210> 2201
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 2201
 Ser Cys Leu Ala Arg Pro Phe Arg Ala Gln Val Ser Ser Ser Gly Phe
   1               5                  10                  15    
 Arg Ala Gln Asn Phe Pro Gly Val Gly Ser Trp Ala Val Ala Val Gly
              20                  25                  30        
 Ala Gly Met Ala Gln Leu Glu Gly Tyr Cys Phe Ser Ala Ala Leu Ser
          35                  40                  45            
 Cys Thr Phe Leu Val Ser Cys Leu Leu Phe Ser Ala Phe Ser Arg Ala
      50                  55                  60                
 Leu Arg Glu Pro Tyr Met Asp Glu Ile Phe His Leu Pro Gln Ala Gln
  65                  70                  75                  80
 Arg Tyr Cys Glu Gly His Phe Ser Leu Ser Gln Trp Asp Pro Met Ile
                  85                  90                  95    
 Thr Thr Leu Pro Gly Leu Tyr Leu Val Ser Val Gly Val Val Lys Pro
             100                 105                 110        
 Ala Ile Trp Ile Phe Gly Trp Ser Glu His Val Val Cys Ser Ile Gly
         115                 120                 125            
 Met Leu Arg Phe Val Asn Leu Leu Phe Ser Val Gly Asn Phe
     130                 135                 140        



      <210> 2202
      <211> 546
      <212> PRT
      <213> Homo sapiens


      <400> 2202
 Phe Arg Arg Leu His Ser Val Pro Arg Gly Ser Ala Leu Cys Ala Met
   1               5                  10                  15    
 Asp Gly Ile Val Pro Asp Ile Ala Val Gly Thr Lys Arg Gly Ser Asp
              20                  25                  30        
 Glu Leu Phe Ser Thr Cys Val Thr Asn Gly Pro Phe Ile Met Ser Ser
          35                  40                  45            
 Asn Ser Ala Ser Ala Ala Asn Gly Asn Asp Ser Lys Lys Phe Lys Gly
      50                  55                  60                
 Asp Ser Arg Ser Ala Gly Val Pro Ser Arg Val Ile His Ile Arg Lys
  65                  70                  75                  80
 Leu Pro Ile Asp Val Thr Glu Gly Glu Val Ile Ser Leu Gly Leu Pro
                  85                  90                  95    
 Phe Gly Lys Val Thr Asn Leu Leu Met Leu Lys Gly Lys Asn Gln Ala
             100                 105                 110        
 Phe Ile Glu Met Asn Thr Glu Glu Ala Ala Asn Thr Met Val Asn Tyr
         115                 120                 125            
 Tyr Thr Ser Val Thr Pro Val Leu Arg Gly Gln Pro Ile Tyr Ile Gln
     130                 135                 140                
 Phe Ser Asn His Lys Glu Leu Lys Thr Asp Ser Ser Pro Asn Gln Ala
 145                 150                 155                 160
 Arg Ala Gln Ala Ala Leu Gln Ala Val Asn Ser Val Gln Ser Gly Asn
                 165                 170                 175    
 Leu Ala Leu Ala Ala Ser Ala Ala Ala Val Asp Ala Gly Met Ala Met
             180                 185                 190        
 Ala Gly Gln Ser Pro Val Leu Arg Ile Ile Val Glu Asn Leu Phe Tyr
         195                 200                 205            
 Pro Val Thr Leu Asp Val Leu His Gln Ile Phe Ser Lys Phe Gly Thr
     210                 215                 220                
 Val Leu Lys Ile Ile Thr Phe Thr Lys Asn Asn Gln Phe Gln Ala Leu
 225                 230                 235                 240
 Leu Gln Tyr Ala Asp Pro Val Ser Ala Gln His Ala Lys Leu Ser Leu
                 245                 250                 255    
 Asp Gly Gln Asn Ile Tyr Asn Ala Cys Cys Thr Leu Arg Ile Asp Phe
             260                 265                 270        
 Ser Lys Leu Thr Ser Leu Asn Val Lys Tyr Asn Asn Asp Lys Ser Arg
         275                 280                 285            
 Asp Tyr Thr Arg Pro Asp Leu Pro Ser Gly Asp Ser Gln Pro Ser Leu
     290                 295                 300                
 Asp Gln Thr Met Ala Ala Ala Phe Gly Leu Ser Val Pro Asn Val His
 305                 310                 315                 320
 Gly Ala Leu Ala Pro Leu Ala Ile Pro Ser Ala Ala Ala Ala Ala Ala
                 325                 330                 335    
 Ala Ala Gly Arg Ile Ala Ile Pro Gly Leu Ala Gly Ala Gly Asn Ser
             340                 345                 350        
 Val Leu Leu Val Ser Asn Leu Asn Pro Glu Arg Val Thr Pro Gln Ser
         355                 360                 365            
 Leu Phe Ile Leu Phe Gly Val Tyr Gly Asp Val Gln Arg Val Lys Ile
     370                 375                 380                
 Leu Phe Asn Lys Lys Glu Asn Ala Leu Val Gln Met Ala Asp Gly Asn
 385                 390                 395                 400
 Gln Ala Gln Leu Ala Met Ser His Leu Asn Gly His Lys Leu His Gly
                 405                 410                 415    
 Lys Pro Ile Arg Ile Thr Leu Ser Lys His Gln Asn Val Gln Leu Pro
             420                 425                 430        
 Arg Glu Gly Gln Glu Asp Gln Gly Leu Thr Lys Asp Tyr Gly Asn Ser
         435                 440                 445            
 Pro Leu His Arg Phe Lys Lys Pro Gly Ser Lys Asn Phe Gln Asn Ile
     450                 455                 460                
 Phe Pro Pro Ser Ala Thr Leu His Leu Ser Asn Ile Pro Pro Ser Val
 465                 470                 475                 480
 Ser Glu Glu Asp Leu Lys Val Leu Phe Ser Ser Asn Gly Gly Val Val
                 485                 490                 495    
 Lys Gly Phe Lys Phe Phe Gln Lys Asp Arg Lys Met Ala Leu Ile Gln
             500                 505                 510        
 Met Gly Ser Val Glu Glu Ala Val Gln Ala Leu Ile Asp Leu His Asn
         515                 520                 525            
 His Asp Leu Gly Glu Asn His His Leu Arg Val Ser Phe Ser Lys Ser
     530                 535                 540                
 Thr Ile
 545    



      <210> 2203
      <211> 573
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(573)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2203
 Arg Arg Pro Pro Glu Gly Gly Ser Gly Gly Gly Arg Arg Thr Arg Ala
   1               5                  10                  15    
 Arg Met Pro Leu Pro Trp Ser Leu Ala Leu Pro Leu Leu Leu Ser Trp
              20                  25                  30        
 Val Ala Gly Gly Phe Gly Asn Ala Ala Ser Ala Arg His His Gly Leu
          35                  40                  45            
 Leu Ala Ser Ala Arg Gln Pro Gly Val Cys His Tyr Gly Thr Lys Leu
      50                  55                  60                
 Ala Cys Cys Tyr Gly Trp Arg Arg Asn Ser Lys Gly Val Cys Glu Ala
  65                  70                  75                  80
 Thr Cys Glu Pro Gly Cys Lys Phe Gly Glu Cys Val Gly Pro Asn Lys
                  85                  90                  95    
 Cys Arg Cys Phe Pro Gly Tyr Thr Gly Lys Thr Cys Ser Gln Asp Val
             100                 105                 110        
 Asn Glu Cys Gly Met Lys Pro Arg Pro Cys Gln His Arg Cys Val Asn
         115                 120                 125            
 Thr His Gly Ser Tyr Lys Cys Phe Cys Leu Ser Gly His Met Leu Met
     130                 135                 140                
 Pro Asp Ala Thr Cys Val Asn Ser Arg Thr Cys Ala Met Ile Asn Cys
 145                 150                 155                 160
 Gln Tyr Ser Cys Glu Asp Thr Glu Glu Gly Pro Gln Cys Leu Cys Pro
                 165                 170                 175    
 Ser Ser Gly Leu Arg Leu Ala Pro Asn Gly Arg Asp Cys Leu Asp Ile
             180                 185                 190        
 Asp Glu Cys Ala Ser Gly Lys Val Ile Cys Pro Tyr Asn Arg Arg Cys
         195                 200                 205            
 Val Asn Thr Phe Gly Ser Tyr Tyr Cys Lys Cys His Ile Gly Phe Glu
     210                 215                 220                
 Leu Gln Tyr Ile Ser Gly Arg Tyr Asp Cys Ile Asp Ile Asn Glu Cys
 225                 230                 235                 240
 Thr Met Asp Ser His Thr Cys Ser His His Ala Asn Cys Phe Asn Thr
                 245                 250                 255    
 Gln Gly Ser Phe Lys Cys Lys Cys Lys Gln Gly Tyr Lys Gly Asn Gly
             260                 265                 270        
 Leu Arg Cys Ser Ala Ile Pro Glu Asn Ser Val Lys Glu Val Leu Arg
         275                 280                 285            
 Ala Pro Gly Thr Ile Lys Asp Arg Ile Lys Lys Leu Leu Ala His Lys
     290                 295                 300                
 Asn Ser Met Lys Lys Lys Ala Lys Ile Lys Asn Val Thr Pro Glu Pro
 305                 310                 315                 320
 Thr Arg Thr Pro Thr Pro Lys Val Asn Leu Gln Pro Phe Asn Tyr Glu
                 325                 330                 335    
 Glu Ile Val Ser Arg Gly Gly Asn Ser His Gly Gly Lys Lys Gly Asn
             340                 345                 350        
 Glu Glu Lys Met Lys Glu Gly Leu Glu Asp Glu Lys Arg Glu Glu Lys
         355                 360                 365            
 Ala Leu Lys Asp Xaa His Arg Arg Glu Arg Pro Phe Arg Gly Asp Val
     370                 375                 380                
 Phe Phe Pro Lys Val Asn Glu Ala Gly Glu Phe Gly Leu Ile Leu Val
 385                 390                 395                 400
 Gln Arg Lys Ala Leu Thr Ser Lys Leu Glu His Lys Ala Asp Leu Asn
                 405                 410                 415    
 Ile Ser Val Asp Cys Ser Phe Asn His Gly Ile Cys Asp Trp Lys Gln
             420                 425                 430        
 Asp Arg Glu Asp Asp Phe Asp Trp Asn Pro Ala Asp Arg Asp Asn Ala
         435                 440                 445            
 Ile Gly Phe Tyr Met Ala Val Pro Gly Leu Trp Gln Gly His Lys Lys
     450                 455                 460                
 Asp Ile Gly Arg Leu Lys Leu Leu Leu Pro Asp Leu Gln Pro Gln Ser
 465                 470                 475                 480
 Asn Phe Cys Leu Leu Phe Asp Tyr Arg Leu Ala Gly Asp Lys Val Gly
                 485                 490                 495    
 Lys Leu Arg Val Phe Val Lys Asn Ser Asn Asn Ala Leu Ala Trp Glu
             500                 505                 510        
 Lys Thr Thr Ser Glu Asp Glu Lys Trp Lys Thr Gly Lys Ile Gln Leu
         515                 520                 525            
 Tyr Gln Gly Thr Asp Ala Thr Lys Ser Ile Ile Phe Glu Ala Glu Arg
     530                 535                 540                
 Gly Lys Gly Lys Thr Gly Glu Ile Ala Val Asp Gly Val Leu Leu Val
 545                 550                 555                 560
 Ser Gly Leu Cys Pro Asp Ser Leu Leu Ser Val Asp Asp
                 565                 570            



      <210> 2204
      <211> 573
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(573)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2204
 Arg Arg Pro Pro Glu Gly Gly Ser Gly Gly Gly Arg Arg Thr Arg Ala
   1               5                  10                  15    
 Arg Met Pro Leu Pro Trp Ser Leu Ala Leu Pro Leu Leu Leu Ser Trp
              20                  25                  30        
 Val Ala Gly Gly Phe Gly Asn Ala Ala Ser Ala Arg His His Gly Leu
          35                  40                  45            
 Leu Ala Ser Ala Arg Gln Pro Gly Val Cys His Tyr Gly Thr Lys Leu
      50                  55                  60                
 Ala Cys Cys Tyr Gly Trp Arg Arg Asn Ser Lys Gly Val Cys Glu Ala
  65                  70                  75                  80
 Thr Cys Glu Pro Gly Cys Lys Phe Gly Glu Cys Val Gly Pro Asn Lys
                  85                  90                  95    
 Cys Arg Cys Phe Pro Gly Tyr Thr Gly Lys Thr Cys Ser Gln Asp Val
             100                 105                 110        
 Asn Glu Cys Gly Met Lys Pro Arg Pro Cys Gln His Arg Cys Val Asn
         115                 120                 125            
 Thr His Gly Ser Tyr Lys Cys Phe Cys Leu Ser Gly His Met Leu Met
     130                 135                 140                
 Pro Asp Ala Thr Cys Val Asn Ser Arg Thr Cys Ala Met Ile Asn Cys
 145                 150                 155                 160
 Gln Tyr Ser Cys Glu Asp Thr Glu Glu Gly Pro Gln Cys Leu Cys Pro
                 165                 170                 175    
 Ser Ser Gly Leu Arg Leu Ala Pro Asn Gly Arg Asp Cys Leu Asp Ile
             180                 185                 190        
 Asp Glu Cys Ala Ser Gly Lys Val Ile Cys Pro Tyr Asn Arg Arg Cys
         195                 200                 205            
 Val Asn Thr Phe Gly Ser Tyr Tyr Cys Lys Cys His Ile Gly Phe Glu
     210                 215                 220                
 Leu Gln Tyr Ile Ser Gly Arg Tyr Asp Cys Ile Asp Ile Asn Glu Cys
 225                 230                 235                 240
 Thr Met Asp Ser His Thr Cys Ser His His Ala Asn Cys Phe Asn Thr
                 245                 250                 255    
 Gln Gly Ser Phe Lys Cys Lys Cys Lys Gln Gly Tyr Lys Gly Asn Gly
             260                 265                 270        
 Leu Arg Cys Ser Ala Ile Pro Glu Asn Ser Val Lys Glu Val Leu Arg
         275                 280                 285            
 Ala Pro Gly Thr Ile Lys Asp Arg Ile Lys Lys Leu Leu Ala His Lys
     290                 295                 300                
 Asn Ser Met Lys Lys Lys Ala Lys Ile Lys Asn Val Thr Pro Glu Pro
 305                 310                 315                 320
 Thr Arg Thr Pro Thr Pro Lys Val Asn Leu Gln Pro Phe Asn Tyr Glu
                 325                 330                 335    
 Glu Ile Val Ser Arg Gly Gly Asn Ser His Gly Gly Lys Lys Gly Asn
             340                 345                 350        
 Glu Glu Lys Met Lys Glu Gly Leu Glu Asp Glu Lys Arg Glu Glu Lys
         355                 360                 365            
 Ala Leu Lys Asp Xaa His Arg Arg Glu Arg Pro Phe Arg Gly Asp Val
     370                 375                 380                
 Phe Phe Pro Lys Val Asn Glu Ala Gly Glu Phe Gly Leu Ile Leu Val
 385                 390                 395                 400
 Gln Arg Lys Ala Leu Thr Ser Lys Leu Glu His Lys Ala Asp Leu Asn
                 405                 410                 415    
 Ile Ser Val Asp Cys Ser Phe Asn His Gly Ile Cys Asp Trp Lys Gln
             420                 425                 430        
 Asp Arg Glu Asp Asp Phe Asp Trp Asn Pro Ala Asp Arg Asp Asn Ala
         435                 440                 445            
 Ile Gly Phe Tyr Met Ala Val Pro Gly Leu Trp Gln Gly His Lys Lys
     450                 455                 460                
 Asp Ile Gly Arg Leu Lys Leu Leu Leu Pro Asp Leu Gln Pro Gln Ser
 465                 470                 475                 480
 Asn Phe Cys Leu Leu Phe Asp Tyr Arg Leu Ala Gly Asp Lys Val Gly
                 485                 490                 495    
 Lys Leu Arg Val Phe Val Lys Asn Ser Asn Asn Ala Leu Ala Trp Glu
             500                 505                 510        
 Lys Thr Thr Ser Glu Asp Glu Lys Trp Lys Thr Gly Lys Ile Gln Leu
         515                 520                 525            
 Tyr Gln Gly Thr Asp Ala Thr Lys Ser Ile Ile Phe Glu Ala Glu Arg
     530                 535                 540                
 Gly Lys Gly Lys Thr Gly Glu Ile Ala Val Asp Gly Val Leu Leu Val
 545                 550                 555                 560
 Ser Gly Leu Cys Pro Asp Ser Leu Leu Ser Val Asp Asp
                 565                 570            



      <210> 2205
      <211> 819
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(819)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2205
 Val Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu
   1               5                  10                  15    
 Val Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser
              20                  25                  30        
 Pro Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu
          35                  40                  45            
 Asp Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu
      50                  55                  60                
 Lys Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met
  65                  70                  75                  80
 Ser Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser
                  85                  90                  95    
 Asp Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly
             100                 105                 110        
 Ser Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe
         115                 120                 125            
 Ser Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser
     130                 135                 140                
 Pro Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro
 145                 150                 155                 160
 Lys Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp
                 165                 170                 175    
 Lys Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser
             180                 185                 190        
 Lys Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln
         195                 200                 205            
 Ser Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg
     210                 215                 220                
 Phe Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu
 225                 230                 235                 240
 Gly Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser
                 245                 250                 255    
 Asp Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile
             260                 265                 270        
 Ser Asp Asp Glu Gln Lys Ser Xaa Gly Thr Ser Gln Glu Asp Thr Glu
         275                 280                 285            
 Asp Lys Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val Lys Lys
     290                 295                 300                
 Lys Pro Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu Lys Ser
 305                 310                 315                 320
 Thr Ser Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys Asp Lys
                 325                 330                 335    
 Ala Ser Pro Glu Pro Glu Lys Asp Phe Ser Gly Lys Ala Lys Pro Ser
             340                 345                 350        
 Pro His Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser
         355                 360                 365            
 Pro Thr Val His Leu Gly Leu Asp Ser Asp Ser Glu Asn Glu Leu Val
     370                 375                 380                
 Ile Asp Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys Asn Lys
 385                 390                 395                 400
 Lys Glu Pro Lys Glu Pro Ser Pro Lys Gln Asp Val Val Gly Lys Thr
                 405                 410                 415    
 Pro Pro Ser Thr Thr Val Gly Ser His Ser Pro Pro Glu Thr Pro Val
             420                 425                 430        
 Leu Thr Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr
         435                 440                 445            
 Thr Ser Thr Ser Ser Thr Val Thr Val Thr Ala Pro Ala Pro Ala Ala
     450                 455                 460                
 Thr Gly Ser Pro Val Lys Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr
 465                 470                 475                 480
 Ala Pro Ala Val Gln Arg Ser Cys Gly Thr Ser Ser Thr Val Gln Gln
                 485                 490                 495    
 Lys Glu Ile Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu Val Thr
             500                 505                 510        
 Ser Thr Gln Ser Ser Pro Leu Val Thr Ser Ser Gly Ser Met Ser Thr
         515                 520                 525            
 Leu Val Ser Ser Val Asn Gly Asp Leu Pro Ile Gly Thr Ala Ser Ala
     530                 535                 540                
 Asp Val Ala Ala Asp Ile Ala Lys Tyr Thr Ser Lys Leu Met Asp Ala
 545                 550                 555                 560
 Ile Lys Gly Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys Asn Thr
                 565                 570                 575    
 Thr Trp Lys Ala Gln Leu Ala Glu Asp Ser Gln Gly Leu Arg Ile Glu
             580                 585                 590        
 Ile Glu Lys Leu Gln Trp Leu His Gln Gln Glu Leu Ser Glu Met Lys
         595                 600                 605            
 His Asn Leu Glu Leu Thr Met Ala Glu Met Arg Gln Ser Trp Glu Gln
     610                 615                 620                
 Glu Arg Asp Arg Leu Ile Ala Glu Val Lys Lys Gln Leu Glu Leu Glu
 625                 630                 635                 640
 Lys Gln Gln Ala Val Asp Glu Thr Lys Lys Lys Gln Trp Cys Ala Asn
                 645                 650                 655    
 Phe Lys Lys Glu Ala Ile Phe Tyr Cys Cys Trp Asn Thr Ser Tyr Cys
             660                 665                 670        
 Asp Tyr Pro Cys Gln Gln Ala His Trp Pro Glu His Met Lys Ser Cys
         675                 680                 685            
 Thr Gln Ser Ala Thr Ala Pro Gln Gln Glu Ala Asp Ala Glu Val Asn
     690                 695                 700                
 Thr Glu Thr Leu Asn Lys Ser Ser Gln Gly Ser Ser Ser Ser Thr Gln
 705                 710                 715                 720
 Ser Ala Pro Ser Glu Thr Ala Ser Ala Ser Lys Glu Lys Glu Thr Ser
                 725                 730                 735    
 Ala Glu Lys Ser Lys Glu Ser Gly Ser Thr Leu Asp Leu Ser Gly Ser
             740                 745                 750        
 Arg Glu Thr Pro Ser Ser Ile Leu Leu Gly Ser Asn Gln Gly Ser Asp
         755                 760                 765            
 His Ser Arg Ser Asn Lys Ser Ser Trp Ser Ser Ser Asp Glu Lys Arg
     770                 775                 780                
 Gly Ser Thr Arg Ser Asp His Asn Thr Pro Ser Thr Gln His Gly Arg
 785                 790                 795                 800
 Ser Leu Leu Pro Gly Lys Glu Ser Arg Ala Gly Thr Pro Phe Leu Gly
                 805                 810                 815    
 Thr Ser Lys
            



      <210> 2206
      <211> 819
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(819)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2206
 Val Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu
   1               5                  10                  15    
 Val Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser
              20                  25                  30        
 Pro Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu
          35                  40                  45            
 Asp Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu
      50                  55                  60                
 Lys Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met
  65                  70                  75                  80
 Ser Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser
                  85                  90                  95    
 Asp Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly
             100                 105                 110        
 Ser Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe
         115                 120                 125            
 Ser Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser
     130                 135                 140                
 Pro Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro
 145                 150                 155                 160
 Lys Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp
                 165                 170                 175    
 Lys Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser
             180                 185                 190        
 Lys Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln
         195                 200                 205            
 Ser Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg
     210                 215                 220                
 Phe Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu
 225                 230                 235                 240
 Gly Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser
                 245                 250                 255    
 Asp Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile
             260                 265                 270        
 Ser Asp Asp Glu Gln Lys Ser Xaa Gly Thr Ser Gln Glu Asp Thr Glu
         275                 280                 285            
 Asp Lys Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val Lys Lys
     290                 295                 300                
 Lys Pro Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu Lys Ser
 305                 310                 315                 320
 Thr Ser Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys Asp Lys
                 325                 330                 335    
 Ala Ser Pro Glu Pro Glu Lys Asp Phe Ser Gly Lys Ala Lys Pro Ser
             340                 345                 350        
 Pro His Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser
         355                 360                 365            
 Pro Thr Val His Leu Gly Leu Asp Ser Asp Ser Glu Asn Glu Leu Val
     370                 375                 380                
 Ile Asp Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys Asn Lys
 385                 390                 395                 400
 Lys Glu Pro Lys Glu Pro Ser Pro Lys Gln Asp Val Val Gly Lys Thr
                 405                 410                 415    
 Pro Pro Ser Thr Thr Val Gly Ser His Ser Pro Pro Glu Thr Pro Val
             420                 425                 430        
 Leu Thr Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr
         435                 440                 445            
 Thr Ser Thr Ser Ser Thr Val Thr Val Thr Ala Pro Ala Pro Ala Ala
     450                 455                 460                
 Thr Gly Ser Pro Val Lys Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr
 465                 470                 475                 480
 Ala Pro Ala Val Gln Arg Ser Cys Gly Thr Ser Ser Thr Val Gln Gln
                 485                 490                 495    
 Lys Glu Ile Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu Val Thr
             500                 505                 510        
 Ser Thr Gln Ser Ser Pro Leu Val Thr Ser Ser Gly Ser Met Ser Thr
         515                 520                 525            
 Leu Val Ser Ser Val Asn Gly Asp Leu Pro Ile Gly Thr Ala Ser Ala
     530                 535                 540                
 Asp Val Ala Ala Asp Ile Ala Lys Tyr Thr Ser Lys Leu Met Asp Ala
 545                 550                 555                 560
 Ile Lys Gly Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys Asn Thr
                 565                 570                 575    
 Thr Trp Lys Ala Gln Leu Ala Glu Asp Ser Gln Gly Leu Arg Ile Glu
             580                 585                 590        
 Ile Glu Lys Leu Gln Trp Leu His Gln Gln Glu Leu Ser Glu Met Lys
         595                 600                 605            
 His Asn Leu Glu Leu Thr Met Ala Glu Met Arg Gln Ser Trp Glu Gln
     610                 615                 620                
 Glu Arg Asp Arg Leu Ile Ala Glu Val Lys Lys Gln Leu Glu Leu Glu
 625                 630                 635                 640
 Lys Gln Gln Ala Val Asp Glu Thr Lys Lys Lys Gln Trp Cys Ala Asn
                 645                 650                 655    
 Phe Lys Lys Glu Ala Ile Phe Tyr Cys Cys Trp Asn Thr Ser Tyr Cys
             660                 665                 670        
 Asp Tyr Pro Cys Gln Gln Ala His Trp Pro Glu His Met Lys Ser Cys
         675                 680                 685            
 Thr Gln Ser Ala Thr Ala Pro Gln Gln Glu Ala Asp Ala Glu Val Asn
     690                 695                 700                
 Thr Glu Thr Leu Asn Lys Ser Ser Gln Gly Ser Ser Ser Ser Thr Gln
 705                 710                 715                 720
 Ser Ala Pro Ser Glu Thr Ala Ser Ala Ser Lys Glu Lys Glu Thr Ser
                 725                 730                 735    
 Ala Glu Lys Ser Lys Glu Ser Gly Ser Thr Leu Asp Leu Ser Gly Ser
             740                 745                 750        
 Arg Glu Thr Pro Ser Ser Ile Leu Leu Gly Ser Asn Gln Gly Ser Asp
         755                 760                 765            
 His Ser Arg Ser Asn Lys Ser Ser Trp Ser Ser Ser Asp Glu Lys Arg
     770                 775                 780                
 Gly Ser Thr Arg Ser Asp His Asn Thr Pro Ser Thr Gln His Gly Arg
 785                 790                 795                 800
 Ser Leu Leu Pro Gly Lys Glu Ser Arg Ala Gly Thr Pro Phe Leu Gly
                 805                 810                 815    
 Thr Ser Lys
            



      <210> 2207
      <211> 819
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(819)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2207
 Val Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu
   1               5                  10                  15    
 Val Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser
              20                  25                  30        
 Pro Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu
          35                  40                  45            
 Asp Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu
      50                  55                  60                
 Lys Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met
  65                  70                  75                  80
 Ser Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser
                  85                  90                  95    
 Asp Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly
             100                 105                 110        
 Ser Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe
         115                 120                 125            
 Ser Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser
     130                 135                 140                
 Pro Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro
 145                 150                 155                 160
 Lys Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp
                 165                 170                 175    
 Lys Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser
             180                 185                 190        
 Lys Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln
         195                 200                 205            
 Ser Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg
     210                 215                 220                
 Phe Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu
 225                 230                 235                 240
 Gly Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser
                 245                 250                 255    
 Asp Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile
             260                 265                 270        
 Ser Asp Asp Glu Gln Lys Ser Xaa Gly Thr Ser Gln Glu Asp Thr Glu
         275                 280                 285            
 Asp Lys Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val Lys Lys
     290                 295                 300                
 Lys Pro Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu Lys Ser
 305                 310                 315                 320
 Thr Ser Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys Asp Lys
                 325                 330                 335    
 Ala Ser Pro Glu Pro Glu Lys Asp Phe Ser Gly Lys Ala Lys Pro Ser
             340                 345                 350        
 Pro His Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser
         355                 360                 365            
 Pro Thr Val His Leu Gly Leu Asp Ser Asp Ser Glu Asn Glu Leu Val
     370                 375                 380                
 Ile Asp Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys Asn Lys
 385                 390                 395                 400
 Lys Glu Pro Lys Glu Pro Ser Pro Lys Gln Asp Val Val Gly Lys Thr
                 405                 410                 415    
 Pro Pro Ser Thr Thr Val Gly Ser His Ser Pro Pro Glu Thr Pro Val
             420                 425                 430        
 Leu Thr Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr
         435                 440                 445            
 Thr Ser Thr Ser Ser Thr Val Thr Val Thr Ala Pro Ala Pro Ala Ala
     450                 455                 460                
 Thr Gly Ser Pro Val Lys Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr
 465                 470                 475                 480
 Ala Pro Ala Val Gln Arg Ser Cys Gly Thr Ser Ser Thr Val Gln Gln
                 485                 490                 495    
 Lys Glu Ile Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu Val Thr
             500                 505                 510        
 Ser Thr Gln Ser Ser Pro Leu Val Thr Ser Ser Gly Ser Met Ser Thr
         515                 520                 525            
 Leu Val Ser Ser Val Asn Gly Asp Leu Pro Ile Gly Thr Ala Ser Ala
     530                 535                 540                
 Asp Val Ala Ala Asp Ile Ala Lys Tyr Thr Ser Lys Leu Met Asp Ala
 545                 550                 555                 560
 Ile Lys Gly Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys Asn Thr
                 565                 570                 575    
 Thr Trp Lys Ala Gln Leu Ala Glu Asp Ser Gln Gly Leu Arg Ile Glu
             580                 585                 590        
 Ile Glu Lys Leu Gln Trp Leu His Gln Gln Glu Leu Ser Glu Met Lys
         595                 600                 605            
 His Asn Leu Glu Leu Thr Met Ala Glu Met Arg Gln Ser Trp Glu Gln
     610                 615                 620                
 Glu Arg Asp Arg Leu Ile Ala Glu Val Lys Lys Gln Leu Glu Leu Glu
 625                 630                 635                 640
 Lys Gln Gln Ala Val Asp Glu Thr Lys Lys Lys Gln Trp Cys Ala Asn
                 645                 650                 655    
 Phe Lys Lys Glu Ala Ile Phe Tyr Cys Cys Trp Asn Thr Ser Tyr Cys
             660                 665                 670        
 Asp Tyr Pro Cys Gln Gln Ala His Trp Pro Glu His Met Lys Ser Cys
         675                 680                 685            
 Thr Gln Ser Ala Thr Ala Pro Gln Gln Glu Ala Asp Ala Glu Val Asn
     690                 695                 700                
 Thr Glu Thr Leu Asn Lys Ser Ser Gln Gly Ser Ser Ser Ser Thr Gln
 705                 710                 715                 720
 Ser Ala Pro Ser Glu Thr Ala Ser Ala Ser Lys Glu Lys Glu Thr Ser
                 725                 730                 735    
 Ala Glu Lys Ser Lys Glu Ser Gly Ser Thr Leu Asp Leu Ser Gly Ser
             740                 745                 750        
 Arg Glu Thr Pro Ser Ser Ile Leu Leu Gly Ser Asn Gln Gly Ser Asp
         755                 760                 765            
 His Ser Arg Ser Asn Lys Ser Ser Trp Ser Ser Ser Asp Glu Lys Arg
     770                 775                 780                
 Gly Ser Thr Arg Ser Asp His Asn Thr Pro Ser Thr Gln His Gly Arg
 785                 790                 795                 800
 Ser Leu Leu Pro Gly Lys Glu Ser Arg Ala Gly Thr Pro Phe Leu Gly
                 805                 810                 815    
 Thr Ser Lys
            



      <210> 2208
      <211> 819
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(819)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2208
 Val Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu
   1               5                  10                  15    
 Val Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser
              20                  25                  30        
 Pro Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu
          35                  40                  45            
 Asp Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu
      50                  55                  60                
 Lys Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met
  65                  70                  75                  80
 Ser Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser
                  85                  90                  95    
 Asp Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly
             100                 105                 110        
 Ser Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe
         115                 120                 125            
 Ser Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser
     130                 135                 140                
 Pro Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro
 145                 150                 155                 160
 Lys Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp
                 165                 170                 175    
 Lys Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser
             180                 185                 190        
 Lys Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln
         195                 200                 205            
 Ser Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg
     210                 215                 220                
 Phe Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu
 225                 230                 235                 240
 Gly Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser
                 245                 250                 255    
 Asp Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile
             260                 265                 270        
 Ser Asp Asp Glu Gln Lys Ser Xaa Gly Thr Ser Gln Glu Asp Thr Glu
         275                 280                 285            
 Asp Lys Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val Lys Lys
     290                 295                 300                
 Lys Pro Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu Lys Ser
 305                 310                 315                 320
 Thr Ser Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys Asp Lys
                 325                 330                 335    
 Ala Ser Pro Glu Pro Glu Lys Asp Phe Ser Gly Lys Ala Lys Pro Ser
             340                 345                 350        
 Pro His Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser
         355                 360                 365            
 Pro Thr Val His Leu Gly Leu Asp Ser Asp Ser Glu Asn Glu Leu Val
     370                 375                 380                
 Ile Asp Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys Asn Lys
 385                 390                 395                 400
 Lys Glu Pro Lys Glu Pro Ser Pro Lys Gln Asp Val Val Gly Lys Thr
                 405                 410                 415    
 Pro Pro Ser Thr Thr Val Gly Ser His Ser Pro Pro Glu Thr Pro Val
             420                 425                 430        
 Leu Thr Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr
         435                 440                 445            
 Thr Ser Thr Ser Ser Thr Val Thr Val Thr Ala Pro Ala Pro Ala Ala
     450                 455                 460                
 Thr Gly Ser Pro Val Lys Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr
 465                 470                 475                 480
 Ala Pro Ala Val Gln Arg Ser Cys Gly Thr Ser Ser Thr Val Gln Gln
                 485                 490                 495    
 Lys Glu Ile Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu Val Thr
             500                 505                 510        
 Ser Thr Gln Ser Ser Pro Leu Val Thr Ser Ser Gly Ser Met Ser Thr
         515                 520                 525            
 Leu Val Ser Ser Val Asn Gly Asp Leu Pro Ile Gly Thr Ala Ser Ala
     530                 535                 540                
 Asp Val Ala Ala Asp Ile Ala Lys Tyr Thr Ser Lys Leu Met Asp Ala
 545                 550                 555                 560
 Ile Lys Gly Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys Asn Thr
                 565                 570                 575    
 Thr Trp Lys Ala Gln Leu Ala Glu Asp Ser Gln Gly Leu Arg Ile Glu
             580                 585                 590        
 Ile Glu Lys Leu Gln Trp Leu His Gln Gln Glu Leu Ser Glu Met Lys
         595                 600                 605            
 His Asn Leu Glu Leu Thr Met Ala Glu Met Arg Gln Ser Trp Glu Gln
     610                 615                 620                
 Glu Arg Asp Arg Leu Ile Ala Glu Val Lys Lys Gln Leu Glu Leu Glu
 625                 630                 635                 640
 Lys Gln Gln Ala Val Asp Glu Thr Lys Lys Lys Gln Trp Cys Ala Asn
                 645                 650                 655    
 Phe Lys Lys Glu Ala Ile Phe Tyr Cys Cys Trp Asn Thr Ser Tyr Cys
             660                 665                 670        
 Asp Tyr Pro Cys Gln Gln Ala His Trp Pro Glu His Met Lys Ser Cys
         675                 680                 685            
 Thr Gln Ser Ala Thr Ala Pro Gln Gln Glu Ala Asp Ala Glu Val Asn
     690                 695                 700                
 Thr Glu Thr Leu Asn Lys Ser Ser Gln Gly Ser Ser Ser Ser Thr Gln
 705                 710                 715                 720
 Ser Ala Pro Ser Glu Thr Ala Ser Ala Ser Lys Glu Lys Glu Thr Ser
                 725                 730                 735    
 Ala Glu Lys Ser Lys Glu Ser Gly Ser Thr Leu Asp Leu Ser Gly Ser
             740                 745                 750        
 Arg Glu Thr Pro Ser Ser Ile Leu Leu Gly Ser Asn Gln Gly Ser Asp
         755                 760                 765            
 His Ser Arg Ser Asn Lys Ser Ser Trp Ser Ser Ser Asp Glu Lys Arg
     770                 775                 780                
 Gly Ser Thr Arg Ser Asp His Asn Thr Pro Ser Thr Gln His Gly Arg
 785                 790                 795                 800
 Ser Leu Leu Pro Gly Lys Glu Ser Arg Ala Gly Thr Pro Phe Leu Gly
                 805                 810                 815    
 Thr Ser Lys
            



      <210> 2209
      <211> 191
      <212> PRT
      <213> Homo sapiens


      <400> 2209
 Gly Gly Ile Pro His Tyr Leu Arg Gly Val Asn Asn Ala Arg Gln Pro
   1               5                  10                  15    
 Trp His Asn Ala Asp Val Arg Leu Arg Tyr Gly Leu Arg Pro Gly Asn
              20                  25                  30        
 Ala Thr Glu Glu Gly Leu Ala Ser Leu His Ser Val Leu Phe Arg Lys
          35                  40                  45            
 Gln Pro Phe Leu Trp Arg Ala Ala Leu Leu Tyr Tyr Thr Ile His Arg
      50                  55                  60                
 Ala Ala Arg Met Ser Phe Arg Gln Leu Phe Gln Asp Leu Glu Arg Tyr
  65                  70                  75                  80
 Val Gln Asp Ala Asp Val Arg Trp Glu Tyr Cys Val Arg Ala Lys Arg
                  85                  90                  95    
 Gly Gln Thr Asp Thr Ser Leu Pro Gly Cys Phe Ser Lys Asp Gln Val
             100                 105                 110        
 Tyr Leu Asp Gly Ile Val Arg Ile Leu Arg His Arg Gln Thr Ile Asp
         115                 120                 125            
 Phe Pro Leu Leu Thr Ser Leu Gly Lys Val Ser Tyr Glu Asp Val Asp
     130                 135                 140                
 His Leu Arg Pro His Gly Val Leu Asp Asn Thr Arg Val Pro His Phe
 145                 150                 155                 160
 Met Gln Asp Leu Ala Arg Tyr Arg Gln Gln Leu Glu His Ile Met Ala
                 165                 170                 175    
 Thr Asn Arg Leu Asp Glu Ala Glu Leu Gly Arg Leu Leu Pro Asp
             180                 185                 190    



      <210> 2210
      <211> 597
      <212> PRT
      <213> Homo sapiens


      <400> 2210
 Leu Gly Leu Gly Ser Gly Thr Leu Leu Ser Val Ser Glu Tyr Lys Lys
   1               5                  10                  15    
 Lys Tyr Arg Glu His Val Leu Gln Leu His Ala Arg Val Lys Glu Arg
              20                  25                  30        
 Asn Ala Arg Ser Val Lys Ile Thr Lys Arg Phe Thr Lys Leu Leu Ile
          35                  40                  45            
 Ala Pro Glu Ser Ala Ala Pro Glu Glu Ala Leu Gly Pro Ala Glu Glu
      50                  55                  60                
 Pro Glu Pro Gly Arg Ala Arg Arg Ser Asp Thr His Thr Phe Asn Arg
  65                  70                  75                  80
 Leu Phe Arg Arg Asp Glu Glu Gly Arg Arg Pro Leu Thr Val Val Leu
                  85                  90                  95    
 Gln Gly Pro Ala Gly Ile Gly Lys Thr Met Ala Ala Lys Lys Ile Leu
             100                 105                 110        
 Tyr Asp Trp Ala Ala Gly Lys Leu Tyr Gln Gly Gln Val Asp Phe Ala
         115                 120                 125            
 Phe Phe Met Pro Cys Gly Glu Leu Leu Glu Arg Pro Gly Thr Arg Ser
     130                 135                 140                
 Leu Ala Asp Leu Ile Leu Asp Gln Cys Pro Asp Arg Gly Ala Pro Val
 145                 150                 155                 160
 Pro Gln Met Leu Ala Gln Pro Gln Arg Leu Leu Phe Ile Leu Asp Gly
                 165                 170                 175    
 Ala Asp Glu Leu Pro Ala Leu Gly Gly Pro Glu Ala Ala Pro Cys Thr
             180                 185                 190        
 Asp Pro Phe Glu Ala Ala Ser Gly Ala Arg Val Leu Gly Gly Leu Leu
         195                 200                 205            
 Ser Lys Ala Leu Leu Pro Thr Ala Leu Leu Leu Val Thr Thr Arg Ala
     210                 215                 220                
 Ala Ala Pro Gly Arg Leu Gln Gly Arg Leu Cys Ser Pro Gln Cys Ala
 225                 230                 235                 240
 Glu Val Arg Gly Phe Ser Asp Lys Asp Lys Lys Lys Tyr Phe Tyr Lys
                 245                 250                 255    
 Phe Phe Arg Asp Glu Arg Arg Ala Glu Arg Ala Tyr Arg Phe Val Lys
             260                 265                 270        
 Glu Asn Glu Thr Leu Phe Ala Leu Cys Phe Val Pro Phe Val Cys Trp
         275                 280                 285            
 Ile Val Cys Thr Val Leu Arg Gln Gln Leu Glu Leu Gly Arg Asp Leu
     290                 295                 300                
 Ser Arg Thr Ser Lys Thr Thr Thr Ser Val Tyr Leu Leu Phe Ile Thr
 305                 310                 315                 320
 Ser Val Leu Ser Ser Ala Pro Val Ala Asp Gly Pro Arg Leu Gln Gly
                 325                 330                 335    
 Asp Leu Arg Asn Leu Cys Arg Leu Ala Arg Glu Gly Val Leu Gly Arg
             340                 345                 350        
 Arg Ala Gln Phe Ala Glu Lys Glu Leu Glu Gln Leu Glu Leu Arg Gly
         355                 360                 365            
 Ser Lys Val Gln Thr Leu Phe Leu Ser Lys Lys Glu Leu Pro Gly Val
     370                 375                 380                
 Leu Glu Thr Glu Val Thr Tyr Gln Phe Ile Asp Gln Ser Phe Gln Glu
 385                 390                 395                 400
 Phe Leu Ala Ala Leu Ser Tyr Leu Leu Glu Asp Gly Gly Val Pro Arg
                 405                 410                 415    
 Thr Ala Ala Gly Gly Val Gly Thr Leu Leu Arg Gly Asp Ala Gln Pro
             420                 425                 430        
 His Ser His Leu Val Leu Thr Thr Arg Phe Leu Phe Gly Leu Leu Ser
         435                 440                 445            
 Ala Glu Arg Met Arg Asp Ile Glu Arg His Phe Gly Cys Met Val Ser
     450                 455                 460                
 Glu Arg Val Lys Gln Glu Ala Leu Arg Trp Val Gln Gly Gln Gly Gln
 465                 470                 475                 480
 Gly Cys Pro Gly Val Ala Pro Glu Val Thr Glu Gly Ala Lys Gly Leu
                 485                 490                 495    
 Glu Asp Thr Glu Glu Pro Glu Glu Glu Glu Glu Gly Glu Glu Pro Asn
             500                 505                 510        
 Tyr Pro Leu Glu Leu Leu Tyr Cys Leu Tyr Glu Thr Gln Glu Asp Ala
         515                 520                 525            
 Phe Val Arg Gln Ala Leu Cys Arg Phe Pro Glu Leu Ala Leu Gln Arg
     530                 535                 540                
 Val Arg Phe Cys Arg Met Asp Val Ala Val Leu Ser Tyr Cys Val Arg
 545                 550                 555                 560
 Cys Cys Pro Ala Gly Gln Ala Leu Arg Leu Ile Ser Cys Arg Leu Val
                 565                 570                 575    
 Ala Ala Gln Glu Lys Lys Lys Lys Ser Leu Gly Lys Arg Leu Gln Ala
             580                 585                 590        
 Ser Leu Gly Gly Gly
         595        



      <210> 2211
      <211> 391
      <212> PRT
      <213> Homo sapiens


      <400> 2211
 Gly Phe Val Glu Ala Gly Glu Glu Cys Tyr Cys Val Ser Gly Gln Glu
   1               5                  10                  15    
 Cys Arg Asp Leu Cys Cys Phe Ala His Asn Cys Ser Leu Arg Pro Gly
              20                  25                  30        
 Ala Gln Cys Ala His Gly Asp Cys Cys Val Arg Cys Leu Leu Lys Pro
          35                  40                  45            
 Ala Gly Ala Leu Cys Arg Gln Ala Met Gly Asp Cys Asp Leu Pro Glu
      50                  55                  60                
 Phe Cys Thr Gly Thr Ser Ser His Cys Pro Pro Asp Val Tyr Leu Leu
  65                  70                  75                  80
 Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly Tyr Cys Trp Asp Gly Ala
                  85                  90                  95    
 Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln Leu Trp Gly Pro Gly Ser
             100                 105                 110        
 His Pro Ala Pro Glu Ala Cys Phe Gln Val Val Asn Ser Ala Gly Asp
         115                 120                 125            
 Ala His Gly Asn Cys Gly Gln Asp Ser Glu Gly His Phe Leu Pro Cys
     130                 135                 140                
 Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu Gln Cys Gln Gly Gly Lys
 145                 150                 155                 160
 Pro Ser Leu Leu Ala Pro His Met Val Pro Val Asp Ser Thr Val His
                 165                 170                 175    
 Leu Asp Gly Gln Glu Val Thr Cys Arg Gly Ala Leu Ala Leu Pro Ser
             180                 185                 190        
 Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu Val Glu Pro Gly Thr Gln
         195                 200                 205            
 Cys Gly Pro Arg Met Val Cys Gln Ser Arg Arg Cys Arg Lys Asn Ala
     210                 215                 220                
 Phe Gln Glu Leu Gln Arg Cys Leu Thr Ala Cys His Ser His Gly Val
 225                 230                 235                 240
 Cys Asn Ser Asn His Asn Cys His Cys Ala Pro Gly Trp Ala Pro Pro
                 245                 250                 255    
 Phe Cys Asp Lys Pro Gly Phe Gly Gly Ser Met Asp Ser Gly Pro Val
             260                 265                 270        
 Gln Ala Glu Asn His Asp Thr Phe Leu Leu Ala Met Leu Leu Ser Val
         275                 280                 285            
 Leu Leu Pro Leu Leu Pro Gly Ala Gly Leu Ala Trp Cys Cys Tyr Arg
     290                 295                 300                
 Leu Pro Gly Ala His Leu Gln Arg Cys Ser Trp Gly Cys Arg Arg Asp
 305                 310                 315                 320
 Pro Ala Cys Ser Gly Pro Lys Asp Gly Pro His Arg Asp His Pro Leu
                 325                 330                 335    
 Gly Gly Val His Pro Met Glu Leu Gly Pro Thr Ala Thr Gly Gln Pro
             340                 345                 350        
 Trp Pro Leu Asp Pro Glu Asn Ser His Glu Pro Ser Ser His Pro Glu
         355                 360                 365            
 Lys Pro Leu Pro Ala Val Ser Pro Asp Pro Gln Ala Asp Gln Val Gln
     370                 375                 380                
 Met Pro Arg Ser Cys Leu Trp
 385                 390    



      <210> 2212
      <211> 198
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(198)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2212
 Xaa Xaa Pro Asp Ala Leu Ser Thr Val Ala Glu Xaa Pro Gly Arg Pro
   1               5                  10                  15    
 Thr Arg Pro Pro Thr Arg Thr Ala Ala Pro Trp Pro Arg Pro Gly Cys
              20                  25                  30        
 Ser Ser Ala Ser Ala Pro Pro Thr Pro Ala Ser Ala Pro Trp Pro Ala
          35                  40                  45            
 Ser Pro Ser Ser Ser Ser Gly Arg Trp Ser Thr Asp Ser Arg Gly Pro
      50                  55                  60                
 Arg Pro Trp Glu Gly Ser Gln Gly Cys Trp His Cys Gly Ser Trp Xaa
  65                  70                  75                  80
 Arg Thr Xaa Cys Thr Cys Lys Ile Ile Gly Gly Pro Gly Ser Arg Gly
                  85                  90                  95    
 Cys Ala Ala Ser Ser Ser Trp Ala Ser Ser Ser Arg Pro Ser Pro Ser
             100                 105                 110        
 Leu Pro Ser Ala Pro Ser Ser Cys Trp Pro Ser Pro Gly Ile Arg Ala
         115                 120                 125            
 Ser Gln Thr Pro Pro Ala Thr Thr Ser Pro Ala Ser Gly Ala Ser Phe
     130                 135                 140                
 Pro Ser Ser Gly Pro Ser Cys Ser Ala Ser Met Pro Thr Ala Thr Gly
 145                 150                 155                 160
 Leu Thr Leu Leu Thr Ser Ala Ser Ser Ala Ile Ser Asp Pro Gly Gly
                 165                 170                 175    
 Ser Val Tyr Ala Xaa Ser Gly Met Val His Gln Ser Gly Lys Glu Pro
             180                 185                 190        
 Ser Thr Val Tyr Thr Ser
         195            



      <210> 2213
      <211> 818
      <212> PRT
      <213> Homo sapiens


      <400> 2213
 Met Ala Leu Gln Asn Ala Leu Tyr Thr Gly Asp Leu Ala Arg Leu Gln
   1               5                  10                  15    
 Glu Leu Phe Pro Pro His Ser Thr Ala Asp Leu Leu Leu Glu Ser Arg
              20                  25                  30        
 Ala Ala Glu Pro Arg Trp Ser Ser His Gln Arg Ala Cys Pro Ile Ala
          35                  40                  45            
 Tyr Thr Leu Ala Gln Glu His Ser His Val Glu Pro Arg Ile Ala Pro
      50                  55                  60                
 Ala Gly Cys Val Ala Arg Leu Val Glu Lys Pro Ser Arg Gly Ser Glu
  65                  70                  75                  80
 Glu His Leu Lys Ser Gly Pro Gly Pro Ile Val Thr Arg Thr Ala Ser
                  85                  90                  95    
 Gly Pro Ala Leu Ala Phe Trp Gln Ala Val Leu Ala Gly Asp Val Gly
             100                 105                 110        
 Cys Val Ser Arg Ile Leu Ala Asp Ser Ser Thr Gly Leu Ala Pro Asp
         115                 120                 125            
 Ser Val Phe Asp Thr Ser Asp Pro Glu Arg Trp Arg Asp Phe Arg Phe
     130                 135                 140                
 Asn Ile Arg Ala Leu Arg Leu Trp Ser Leu Thr Tyr Glu Glu Glu Leu
 145                 150                 155                 160
 Thr Thr Pro Leu His Val Ala Ala Ser Arg Gly His Thr Glu Val Leu
                 165                 170                 175    
 Arg Leu Leu Leu Arg Arg Arg Ala Arg Pro Asp Ser Ala Pro Gly Gly
             180                 185                 190        
 Arg Thr Ala Leu His Glu Ala Cys Ala Ala Gly His Thr Ala Cys Val
         195                 200                 205            
 His Val Leu Leu Val Ala Gly Ala Asp Pro Asn Ile Ala Asp Gln Asp
     210                 215                 220                
 Gly Lys Arg Pro Leu His Leu Cys Arg Gly Pro Gly Thr Leu Glu Cys
 225                 230                 235                 240
 Ala Glu Leu Leu Leu Arg Phe Gly Ala Arg Val Asp Gly Arg Ser Glu
                 245                 250                 255    
 Glu Glu Glu Glu Thr Pro Leu His Val Ala Ala Arg Leu Gly His Val
             260                 265                 270        
 Glu Leu Ala Asp Leu Leu Leu Arg Arg Gly Ala Cys Pro Asp Ala Arg
         275                 280                 285            
 Asn Ala Glu Gly Trp Thr Pro Leu Leu Ala Ala Cys Asp Val Arg Cys
     290                 295                 300                
 Gln Ser Ile Thr Asp Ala Glu Ala Thr Thr Ala Arg Cys Leu Gln Leu
 305                 310                 315                 320
 Cys Ser Leu Leu Leu Ser Ala Gly Ala Asp Ala Asp Ala Ala Asp Gln
                 325                 330                 335    
 Asp Lys Gln Arg Pro Leu His Leu Ala Cys Arg Arg Gly His Ala Ala
             340                 345                 350        
 Val Val Glu Leu Leu Leu Ser Cys Gly Val Ser Ala Asn Thr Met Asp
         355                 360                 365            
 Tyr Gly Gly His Thr Pro Leu His Cys Ala Leu Gln Gly Pro Ala Ala
     370                 375                 380                
 Ala Leu Ala Gln Ser Pro Glu His Val Val Arg Ala Leu Leu Asn His
 385                 390                 395                 400
 Gly Ala Val Arg Val Trp Pro Gly Ala Leu Pro Lys Val Leu Glu Arg
                 405                 410                 415    
 Trp Ser Thr Cys Pro Arg Thr Ile Glu Val Leu Met Asn Thr Tyr Ser
             420                 425                 430        
 Val Val Gln Leu Pro Glu Glu Ala Val Gly Leu Val Thr Pro Glu Thr
         435                 440                 445            
 Leu Gln Lys His Gln Arg Phe Tyr Ser Ser Leu Phe Ala Leu Val Arg
     450                 455                 460                
 Gln Pro Arg Ser Leu Gln His Leu Ser Arg Cys Ala Leu Arg Ser His
 465                 470                 475                 480
 Leu Glu Gly Ser Leu Pro Gln Ala Leu Pro Arg Leu Pro Leu Pro Pro
                 485                 490                 495    
 Arg Leu Leu Arg Tyr Leu Gln Leu Asp Phe Glu Gly Val Ser Pro Gly
             500                 505                 510        
 Ile Cys Glu Gln Ser Gln Leu Leu Gly Val Gln Gly Cys Val Glu Gly
         515                 520                 525            
 Lys Arg Arg Val Gly Glu Gly Pro Ser Gln Asn Arg Pro Val Pro Glu
     530                 535                 540                
 Pro Pro Glu Ala Ser Glu Ser Lys Pro Leu Leu Pro Asp Val His Gly
 545                 550                 555                 560
 Leu Leu Arg Gly Pro Glu Ser Arg Cys Pro Ser Leu Gln Arg Ala Arg
                 565                 570                 575    
 Leu Cys Thr Asn Ser Gly Gln Val Ala Leu Ala Ala Gly Gly Pro Ala
             580                 585                 590        
 Pro Gln Ala Gly Val Asp Ala Ala Ile Pro Asn Ala Glu Lys Arg Thr
         595                 600                 605            
 Asp Ser Gly Ser Arg Pro Phe Gln Gly Leu Leu Arg Ser Gly Thr Ala
     610                 615                 620                
 His Gly Gly Lys Asp Cys Pro Pro Gly Pro His Gln Val Arg Leu Ala
 625                 630                 635                 640
 Gly Ser Arg Ser Ala Ala His Arg Arg Lys Arg Gln Leu Cys Ala Ala
                 645                 650                 655    
 Ala Thr Arg Gly His Pro Arg Pro Gly Pro Thr Leu Pro Thr Met Arg
             660                 665                 670        
 Gly Leu Ser Leu Ala Asn Glu Trp Ile Gly Ala Ser Phe Ala Gly Arg
         675                 680                 685            
 Leu Thr Asn Thr Phe Cys Ala Gly Leu Gly Gln Ala Val Pro Ser Met
     690                 695                 700                
 Val Ala Leu Thr Thr Ala Leu Pro Ser Phe Ala Glu Pro Pro Asp Ala
 705                 710                 715                 720
 Phe Tyr Gly Pro Gln Glu Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala
                 725                 730                 735    
 Thr Ala Ala Arg Asn Asn Pro Glu Pro Gly Gly Arg Arg Pro Glu Gly
             740                 745                 750        
 Gly Leu Glu Ala Asp Glu Leu Leu Pro Ala Arg Glu Lys Val Ala Glu
         755                 760                 765            
 Pro Pro Pro Pro Pro Pro Pro His Phe Ser Glu Thr Phe Pro Ser Leu
     770                 775                 780                
 Pro Gly Val Asp Lys Leu Gln Gly Trp Asp Phe Arg Gly His Gln Asp
 785                 790                 795                 800
 Gly Gly Met Leu Lys Gln Leu Ser Ile Gln Gln Trp Arg Ala Arg Ser
                 805                 810                 815    
 Gly Phe
        



      <210> 2214
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 2214
 Asn Val Phe Ile Glu Pro Arg Ile Gln Gly Phe Met Lys Thr Ser Ala
   1               5                  10                  15    
 His Pro Gly Gln Lys His Pro Asp Phe Ser Met Gly Leu Leu Phe Pro
              20                  25                  30        
 Leu Leu Ala Ala Leu Glu Val Cys Ser Cys Gly Ser Ser Gly Ser Leu
          35                  40                  45            
 Gly Tyr Asn Leu Pro Gln Asn His Gly Leu Leu Gly Arg Asn Thr Leu
      50                  55                  60                
 Val Leu Leu Gly Gln Met Arg Arg Ile Ser Pro Phe Leu Cys Leu Lys
  65                  70                  75                  80
 Asp Arg Ser Asp Phe Arg Phe Pro Gln Glu Lys Val Glu Val Ser Gln
                  85                  90                  95    
 Leu Gln Lys Ala Gln Ala Met Ser Phe Leu Tyr Asp Val Leu Gln Gln
             100                 105                 110        
 Val Phe Asn Phe Ser His Lys Ala Leu Leu Cys Cys Met Glu His Asp
         115                 120                 125            
 Leu Pro Gly Pro Thr Pro His Phe Thr Ser Ser Ala Ala Gly Thr Pro
     130                 135                 140                
 Gly Asp Leu Leu Gly Ala Gly Asp Gly Arg Arg Arg Ser Trp Gly Gln
 145                 150                 155                 160
 Trp Val Ile Glu Gly Ser Thr Leu Ala Leu Arg Arg Tyr Phe Gln Glu
                 165                 170                 175    
 Ser Ile Ser Thr Leu Glu
             180        



      <210> 2215
      <211> 320
      <212> PRT
      <213> Homo sapiens


      <400> 2215
 Gln Leu Trp Gly Phe Ala Ala Gly Ser Asp Ser Arg Pro Ala Met Gly
   1               5                  10                  15    
 Cys Asp Gly Gly Thr Ile Pro Lys Arg His Glu Leu Val Lys Gly Pro
              20                  25                  30        
 Lys Lys Val Glu Lys Val Asp Lys Asp Ala Glu Leu Val Ala Gln Trp
          35                  40                  45            
 Asn Tyr Cys Thr Leu Ser Gln Glu Ile Leu Arg Arg Pro Ile Val Ala
      50                  55                  60                
 Cys Glu Leu Gly Arg Leu Tyr Asn Lys Asp Ala Val Ile Glu Phe Leu
  65                  70                  75                  80
 Leu Asp Lys Ser Ala Glu Lys Ala Leu Gly Lys Ala Ala Ser His Ile
                  85                  90                  95    
 Lys Ser Ile Lys Asn Val Thr Glu Leu Lys Leu Ser Asp Asn Pro Ala
             100                 105                 110        
 Trp Glu Gly Asp Lys Gly Asn Thr Lys Gly Asp Lys His Asp Asp Leu
         115                 120                 125            
 Gln Arg Ala Arg Phe Ile Cys Pro Val Val Gly Leu Glu Met Asn Gly
     130                 135                 140                
 Arg His Arg Phe Cys Phe Leu Arg Cys Cys Gly Cys Val Phe Ser Glu
 145                 150                 155                 160
 Arg Ala Leu Lys Glu Ile Lys Ala Glu Val Cys His Thr Cys Gly Ala
                 165                 170                 175    
 Ala Phe Gln Glu Asp Asp Val Ile Val Leu Asn Gly Thr Lys Glu Asp
             180                 185                 190        
 Val Asp Val Leu Lys Thr Arg Met Glu Glu Arg Arg Leu Arg Ala Lys
         195                 200                 205            
 Leu Glu Lys Lys Thr Lys Lys Pro Lys Ala Ala Glu Ser Val Ser Lys
     210                 215                 220                
 Pro Asp Val Ser Glu Glu Ala Pro Gly Pro Ser Lys Val Lys Thr Gly
 225                 230                 235                 240
 Lys Pro Glu Glu Ala Ser Leu Asp Ser Arg Glu Lys Lys Thr Asn Leu
                 245                 250                 255    
 Ala Pro Lys Ser Thr Ala Met Asn Glu Ser Ser Ser Gly Lys Ala Gly
             260                 265                 270        
 Lys Pro Pro Cys Gly Ala Thr Lys Arg Ser Ile Ala Asp Ser Glu Glu
         275                 280                 285            
 Ser Glu Ala Tyr Lys Ser Leu Phe Thr Thr His Ser Ser Ala Lys Arg
     290                 295                 300                
 Ser Lys Glu Glu Ser Ala His Trp Val Thr His Thr Ser Tyr Cys Phe
 305                 310                 315                 320





      <210> 2216
      <211> 161
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(161)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2216
 Phe Cys Pro Leu Gly Lys Pro Val Met Gly Pro Ile Phe Leu Asp Cys
   1               5                  10                  15    
 Arg Pro Phe Phe Leu Phe Pro Lys Pro Asn Gln Gly Thr Gly Thr Pro
              20                  25                  30        
 Leu His Asn Lys Val Pro Tyr Phe Phe Gln Xaa Gly Pro Phe Gly Pro
          35                  40                  45            
 Leu Trp Asn His Arg Thr Leu Phe Phe Phe Leu Arg Trp Ser Phe Ala
      50                  55                  60                
 Leu Leu Ala Gln Ala Gly Val Gln Trp Arg Asp Leu Gly Ser Leu Gln
  65                  70                  75                  80
 Pro Leu Pro Pro Gly Phe Lys Xaa Phe Ser Cys Leu Ser Leu Pro Ser
                  85                  90                  95    
 Ile Trp Asp Tyr Arg Arg Leu Pro Pro Cys Pro Ala Asn Phe Ala Phe
             100                 105                 110        
 Leu Val Glu Thr Gly Phe Leu His Val Gly Gln Val Gly Leu Xaa Leu
         115                 120                 125            
 Leu Thr Ser Gly Asp Pro Ser Ala Ser Ala Ser Gln Ser Ser Gly Ile
     130                 135                 140                
 Thr Gly Val Ser His His Thr Trp Pro Xaa Leu Ser Phe Leu Leu Trp
 145                 150                 155                 160
 Ile
    



      <210> 2217
      <211> 110
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(110)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2217
 Ala Arg Ala Ala Ala Arg Ala Gly Phe Ser Ser Tyr Leu Lys Ser Leu
   1               5                  10                  15    
 Pro Asp Val Arg Lys Lys Ser Leu Pro Leu Pro Glu Lys Pro His Lys
              20                  25                  30        
 Glu Glu Asn Ser Glu Ile Val Val Trp Arg Glu Phe Asp Lys Gln Val
          35                  40                  45            
 Phe Leu Leu Asn Xaa Ser Pro Arg Arg Gln Ser Lys Leu Tyr Thr Val
      50                  55                  60                
 Asp Leu Glu Ser Gly Leu His Tyr Leu Leu Arg Val Glu Leu Ala Ala
  65                  70                  75                  80
 His Lys Ser Leu Ala Gly Ala Glu Leu Lys Thr Leu Lys Asp Phe Val
                  85                  90                  95    
 Thr Val Leu Ala Lys Leu Phe Pro Gly Arg Pro Pro Val Lys
             100                 105                 110



      <210> 2218
      <211> 402
      <212> PRT
      <213> Homo sapiens


      <400> 2218
 Met Ala Leu Ser Ser Trp Pro Val Val Leu Arg Leu Asn Met Ala Asp
   1               5                  10                  15    
 Phe Val Phe Ser Phe Leu Cys Leu Gly Ile Gly Thr Ser Ile Val Leu
              20                  25                  30        
 Gly Ile Leu Phe Tyr Leu Leu Gln Ala His Arg Tyr Leu Gln Glu Gly
          35                  40                  45            
 Met Thr Tyr Gln Leu Ala Leu Ser Phe Tyr Leu Thr Trp Ala Ser Val
      50                  55                  60                
 Phe Leu Phe Leu Met Thr Gly Met Gly Glu Asp Glu Glu Ser Ala Leu
  65                  70                  75                  80
 Gln Thr Leu Leu Asp Pro Arg Ser Ser Tyr Leu Leu Val Ser Leu Glu
                  85                  90                  95    
 Ile Leu Pro Thr Asn Pro Ser Pro Leu Ser Pro Cys Ala Val Ser Glu
             100                 105                 110        
 Asp Glu Ser Glu Met Arg Gly Leu Ser Leu Leu Arg Arg Gln Ser Gln
         115                 120                 125            
 Ala Thr Gly Arg Leu Glu Pro Thr Phe Lys His Asp Ser Thr Leu Leu
     130                 135                 140                
 Ala Leu Gln Gly Ala Leu Gly Leu Tyr Asp Gly His Thr Pro Pro Tyr
 145                 150                 155                 160
 Ala Ala Cys Leu Gly Phe Glu Phe Arg Lys His Leu Gly Asn Pro Ala
                 165                 170                 175    
 Lys Asp Gly Gly Asn Val Thr Val Ser Leu Phe Tyr Arg Asn Asp Ser
             180                 185                 190        
 Ala His Leu Pro Leu Pro Leu Ser Leu Pro Gly Cys Pro Ala Pro Cys
         195                 200                 205            
 Pro Leu Gly Arg Phe Tyr Gln Leu Thr Ala Pro Ala Arg Pro Pro Ala
     210                 215                 220                
 His Gly Val Ser Cys His Gly Pro Tyr Glu Ala Val Ile Pro Pro Gly
 225                 230                 235                 240
 Pro Gly Ala Ile Ile Pro Ser Thr Gly Pro Ala Val Gly Met Gln Arg
                 245                 250                 255    
 Glu Arg Ser Glu Val Gly Ser Gly Val Pro Ala Arg Thr Val Tyr Ala
             260                 265                 270        
 Ser Glu Gln His Ala Tyr Met Trp His Ser Ala Leu Ile Pro Asp Ser
         275                 280                 285            
 Gly Leu Arg Gly Lys Pro Thr Leu Ser Ser Arg Lys Pro Pro Gln Thr
     290                 295                 300                
 Ser Cys Gly Pro Glu Phe Ala Asn Val Leu Ser Leu Ala Leu Cys Gly
 305                 310                 315                 320
 Ala Leu Val Val Cys Lys Ala Arg Ala Met Asp Gln Ala Arg Pro Arg
                 325                 330                 335    
 Gln Leu Ile Gly Ile Asp Ala Leu Arg Asp Pro Arg Ala Ser Ser Arg
             340                 345                 350        
 Thr Arg Ala Gly Gly Leu Gly Met Ile Arg Arg Gln Glu Glu Glu Pro
         355                 360                 365            
 Ala Ala Arg Thr Val Leu Ala Arg Cys Asp Ser Ser Pro Ser Glu Cys
     370                 375                 380                
 Pro Ser His Ala Arg Ala Pro Tyr Asp Thr Gly Pro Leu Phe Asn Ala
 385                 390                 395                 400
 Lys Gly
        



      <210> 2219
      <211> 531
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(531)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2219
 Asn Gly Gly Gly Ser Leu Asn Asn Tyr Ser Ser Pro Ile Pro Ser Thr
   1               5                  10                  15    
 Pro Ala Pro Ser Arg Arg Asp Pro Gln Phe Ser Val Pro Pro Thr Ala
              20                  25                  30        
 Asn Thr Pro Thr Pro Val Cys Lys Arg Ser Met Arg Trp Ser Asn Leu
          35                  40                  45            
 Phe Thr Ser Glu Lys Gly Ser Asp Pro Asp Lys Glu Arg Lys Ala Pro
      50                  55                  60                
 Glu Asn His Ala Asp Thr Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys
  65                  70                  75                  80
 Gln Gly Met Leu Leu Lys Arg Ser Gly Lys Trp Leu Lys Thr Trp Lys
                  85                  90                  95    
 Lys Lys Tyr Val Thr Leu Cys Ser Asn Gly Met Leu Thr Tyr Tyr Ser
             100                 105                 110        
 Ser Leu Gly Asp Tyr Met Lys Asn Ile His Lys Lys Glu Ile Asp Leu
         115                 120                 125            
 Gln Thr Ser Thr Ile Lys Val Pro Gly Lys Trp Pro Ser Leu Ala Thr
     130                 135                 140                
 Ser Ala Cys Thr Pro Ile Ser Ser Ser Lys Ser Asn Gly Leu Ser Lys
 145                 150                 155                 160
 Asp Met Asp Thr Gly Leu Gly Asp Ser Ile Cys Phe Ser Pro Ser Ile
                 165                 170                 175    
 Ser Ser Thr Thr Ser Pro Lys Leu Asn Pro Pro Pro Ser Pro His Ala
             180                 185                 190        
 Asn Lys Lys Lys His Leu Lys Lys Lys Ser Thr Asn Asn Phe Met Ile
         195                 200                 205            
 Val Ser Ala Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr Glu
     210                 215                 220                
 Glu Arg Asp Ala Trp Val Gln Ala Ile Gln Ser Gln Ile Leu Ala Ser
 225                 230                 235                 240
 Leu Gln Ser Cys Glu Ser Ser Lys Ser Lys Ser Gln Leu Thr Ser Gln
                 245                 250                 255    
 Ser Glu Ala Met Ala Leu Gln Ser Ile Gln Asn Met Arg Gly Asn Ala
             260                 265                 270        
 His Cys Val Asp Cys Glu Thr Gln Asn Pro Lys Trp Ala Ser Leu Asn
         275                 280                 285            
 Leu Gly Val Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Ser Leu
     290                 295                 300                
 Gly Pro His Leu Ser Arg Val Arg Ser Leu Glu Leu Asp Asp Trp Pro
 305                 310                 315                 320
 Val Glu Leu Arg Lys Val Met Ser Ser Ile Val Asn Asp Leu Ala Asn
                 325                 330                 335    
 Ser Ile Trp Glu Gly Ser Ser Gln Gly Gln Thr Lys Pro Ser Glu Lys
             340                 345                 350        
 Ser Thr Arg Glu Glu Lys Glu Arg Trp Ile Arg Ser Lys Tyr Glu Glu
         355                 360                 365            
 Lys Leu Phe Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly Gln
     370                 375                 380                
 Gln Leu Leu Arg Ala Thr Ala Asp Glu Asp Leu Gln Thr Ala Ile Leu
 385                 390                 395                 400
 Leu Leu Ala His Gly Ser Cys Glu Glu Val Asn Glu Thr Cys Gly Glu
                 405                 410                 415    
 Gly Asp Gly Cys Thr Ala Leu His Leu Ala Cys Arg Lys Gly Asn Val
             420                 425                 430        
 Val Leu Ala Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Met Ala Arg
         435                 440                 445            
 Asp Ala His Gly Asn Thr Ala Leu Thr Tyr Ala Arg Gln Ala Ser Ser
     450                 455                 460                
 Gln Glu Cys Ile Asn Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu Cys
 465                 470                 475                 480
 Val Xaa Tyr Leu Phe Tyr Leu Thr Ala Val Ser Leu Val Gln Lys Gln
                 485                 490                 495    
 Asn Gly Lys Asn Lys Asp Asn Ser Glu Phe Gln Lys Glu Ile Thr Asn
             500                 505                 510        
 Ser Ala Asn Asn Ser Ile Phe Ser Thr Phe Arg Lys Leu Ser Lys Tyr
         515                 520                 525            
 Thr Lys Cys
     530    



      <210> 2220
      <211> 531
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(531)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2220
 Asn Gly Gly Gly Ser Leu Asn Asn Tyr Ser Ser Pro Ile Pro Ser Thr
   1               5                  10                  15    
 Pro Ala Pro Ser Arg Arg Asp Pro Gln Phe Ser Val Pro Pro Thr Ala
              20                  25                  30        
 Asn Thr Pro Thr Pro Val Cys Lys Arg Ser Met Arg Trp Ser Asn Leu
          35                  40                  45            
 Phe Thr Ser Glu Lys Gly Ser Asp Pro Asp Lys Glu Arg Lys Ala Pro
      50                  55                  60                
 Glu Asn His Ala Asp Thr Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys
  65                  70                  75                  80
 Gln Gly Met Leu Leu Lys Arg Ser Gly Lys Trp Leu Lys Thr Trp Lys
                  85                  90                  95    
 Lys Lys Tyr Val Thr Leu Cys Ser Asn Gly Met Leu Thr Tyr Tyr Ser
             100                 105                 110        
 Ser Leu Gly Asp Tyr Met Lys Asn Ile His Lys Lys Glu Ile Asp Leu
         115                 120                 125            
 Gln Thr Ser Thr Ile Lys Val Pro Gly Lys Trp Pro Ser Leu Ala Thr
     130                 135                 140                
 Ser Ala Cys Thr Pro Ile Ser Ser Ser Lys Ser Asn Gly Leu Ser Lys
 145                 150                 155                 160
 Asp Met Asp Thr Gly Leu Gly Asp Ser Ile Cys Phe Ser Pro Ser Ile
                 165                 170                 175    
 Ser Ser Thr Thr Ser Pro Lys Leu Asn Pro Pro Pro Ser Pro His Ala
             180                 185                 190        
 Asn Lys Lys Lys His Leu Lys Lys Lys Ser Thr Asn Asn Phe Met Ile
         195                 200                 205            
 Val Ser Ala Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr Glu
     210                 215                 220                
 Glu Arg Asp Ala Trp Val Gln Ala Ile Gln Ser Gln Ile Leu Ala Ser
 225                 230                 235                 240
 Leu Gln Ser Cys Glu Ser Ser Lys Ser Lys Ser Gln Leu Thr Ser Gln
                 245                 250                 255    
 Ser Glu Ala Met Ala Leu Gln Ser Ile Gln Asn Met Arg Gly Asn Ala
             260                 265                 270        
 His Cys Val Asp Cys Glu Thr Gln Asn Pro Lys Trp Ala Ser Leu Asn
         275                 280                 285            
 Leu Gly Val Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Ser Leu
     290                 295                 300                
 Gly Pro His Leu Ser Arg Val Arg Ser Leu Glu Leu Asp Asp Trp Pro
 305                 310                 315                 320
 Val Glu Leu Arg Lys Val Met Ser Ser Ile Val Asn Asp Leu Ala Asn
                 325                 330                 335    
 Ser Ile Trp Glu Gly Ser Ser Gln Gly Gln Thr Lys Pro Ser Glu Lys
             340                 345                 350        
 Ser Thr Arg Glu Glu Lys Glu Arg Trp Ile Arg Ser Lys Tyr Glu Glu
         355                 360                 365            
 Lys Leu Phe Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly Gln
     370                 375                 380                
 Gln Leu Leu Arg Ala Thr Ala Asp Glu Asp Leu Gln Thr Ala Ile Leu
 385                 390                 395                 400
 Leu Leu Ala His Gly Ser Cys Glu Glu Val Asn Glu Thr Cys Gly Glu
                 405                 410                 415    
 Gly Asp Gly Cys Thr Ala Leu His Leu Ala Cys Arg Lys Gly Asn Val
             420                 425                 430        
 Val Leu Ala Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Met Ala Arg
         435                 440                 445            
 Asp Ala His Gly Asn Thr Ala Leu Thr Tyr Ala Arg Gln Ala Ser Ser
     450                 455                 460                
 Gln Glu Cys Ile Asn Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu Cys
 465                 470                 475                 480
 Val Xaa Tyr Leu Phe Tyr Leu Thr Ala Val Ser Leu Val Gln Lys Gln
                 485                 490                 495    
 Asn Gly Lys Asn Lys Asp Asn Ser Glu Phe Gln Lys Glu Ile Thr Asn
             500                 505                 510        
 Ser Ala Asn Asn Ser Ile Phe Ser Thr Phe Arg Lys Leu Ser Lys Tyr
         515                 520                 525            
 Thr Lys Cys
     530    



      <210> 2221
      <211> 531
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(531)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2221
 Asn Gly Gly Gly Ser Leu Asn Asn Tyr Ser Ser Pro Ile Pro Ser Thr
   1               5                  10                  15    
 Pro Ala Pro Ser Arg Arg Asp Pro Gln Phe Ser Val Pro Pro Thr Ala
              20                  25                  30        
 Asn Thr Pro Thr Pro Val Cys Lys Arg Ser Met Arg Trp Ser Asn Leu
          35                  40                  45            
 Phe Thr Ser Glu Lys Gly Ser Asp Pro Asp Lys Glu Arg Lys Ala Pro
      50                  55                  60                
 Glu Asn His Ala Asp Thr Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys
  65                  70                  75                  80
 Gln Gly Met Leu Leu Lys Arg Ser Gly Lys Trp Leu Lys Thr Trp Lys
                  85                  90                  95    
 Lys Lys Tyr Val Thr Leu Cys Ser Asn Gly Met Leu Thr Tyr Tyr Ser
             100                 105                 110        
 Ser Leu Gly Asp Tyr Met Lys Asn Ile His Lys Lys Glu Ile Asp Leu
         115                 120                 125            
 Gln Thr Ser Thr Ile Lys Val Pro Gly Lys Trp Pro Ser Leu Ala Thr
     130                 135                 140                
 Ser Ala Cys Thr Pro Ile Ser Ser Ser Lys Ser Asn Gly Leu Ser Lys
 145                 150                 155                 160
 Asp Met Asp Thr Gly Leu Gly Asp Ser Ile Cys Phe Ser Pro Ser Ile
                 165                 170                 175    
 Ser Ser Thr Thr Ser Pro Lys Leu Asn Pro Pro Pro Ser Pro His Ala
             180                 185                 190        
 Asn Lys Lys Lys His Leu Lys Lys Lys Ser Thr Asn Asn Phe Met Ile
         195                 200                 205            
 Val Ser Ala Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr Glu
     210                 215                 220                
 Glu Arg Asp Ala Trp Val Gln Ala Ile Gln Ser Gln Ile Leu Ala Ser
 225                 230                 235                 240
 Leu Gln Ser Cys Glu Ser Ser Lys Ser Lys Ser Gln Leu Thr Ser Gln
                 245                 250                 255    
 Ser Glu Ala Met Ala Leu Gln Ser Ile Gln Asn Met Arg Gly Asn Ala
             260                 265                 270        
 His Cys Val Asp Cys Glu Thr Gln Asn Pro Lys Trp Ala Ser Leu Asn
         275                 280                 285            
 Leu Gly Val Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Ser Leu
     290                 295                 300                
 Gly Pro His Leu Ser Arg Val Arg Ser Leu Glu Leu Asp Asp Trp Pro
 305                 310                 315                 320
 Val Glu Leu Arg Lys Val Met Ser Ser Ile Val Asn Asp Leu Ala Asn
                 325                 330                 335    
 Ser Ile Trp Glu Gly Ser Ser Gln Gly Gln Thr Lys Pro Ser Glu Lys
             340                 345                 350        
 Ser Thr Arg Glu Glu Lys Glu Arg Trp Ile Arg Ser Lys Tyr Glu Glu
         355                 360                 365            
 Lys Leu Phe Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly Gln
     370                 375                 380                
 Gln Leu Leu Arg Ala Thr Ala Asp Glu Asp Leu Gln Thr Ala Ile Leu
 385                 390                 395                 400
 Leu Leu Ala His Gly Ser Cys Glu Glu Val Asn Glu Thr Cys Gly Glu
                 405                 410                 415    
 Gly Asp Gly Cys Thr Ala Leu His Leu Ala Cys Arg Lys Gly Asn Val
             420                 425                 430        
 Val Leu Ala Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Met Ala Arg
         435                 440                 445            
 Asp Ala His Gly Asn Thr Ala Leu Thr Tyr Ala Arg Gln Ala Ser Ser
     450                 455                 460                
 Gln Glu Cys Ile Asn Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu Cys
 465                 470                 475                 480
 Val Xaa Tyr Leu Phe Tyr Leu Thr Ala Val Ser Leu Val Gln Lys Gln
                 485                 490                 495    
 Asn Gly Lys Asn Lys Asp Asn Ser Glu Phe Gln Lys Glu Ile Thr Asn
             500                 505                 510        
 Ser Ala Asn Asn Ser Ile Phe Ser Thr Phe Arg Lys Leu Ser Lys Tyr
         515                 520                 525            
 Thr Lys Cys
     530    



      <210> 2222
      <211> 531
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(531)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2222
 Asn Gly Gly Gly Ser Leu Asn Asn Tyr Ser Ser Pro Ile Pro Ser Thr
   1               5                  10                  15    
 Pro Ala Pro Ser Arg Arg Asp Pro Gln Phe Ser Val Pro Pro Thr Ala
              20                  25                  30        
 Asn Thr Pro Thr Pro Val Cys Lys Arg Ser Met Arg Trp Ser Asn Leu
          35                  40                  45            
 Phe Thr Ser Glu Lys Gly Ser Asp Pro Asp Lys Glu Arg Lys Ala Pro
      50                  55                  60                
 Glu Asn His Ala Asp Thr Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys
  65                  70                  75                  80
 Gln Gly Met Leu Leu Lys Arg Ser Gly Lys Trp Leu Lys Thr Trp Lys
                  85                  90                  95    
 Lys Lys Tyr Val Thr Leu Cys Ser Asn Gly Met Leu Thr Tyr Tyr Ser
             100                 105                 110        
 Ser Leu Gly Asp Tyr Met Lys Asn Ile His Lys Lys Glu Ile Asp Leu
         115                 120                 125            
 Gln Thr Ser Thr Ile Lys Val Pro Gly Lys Trp Pro Ser Leu Ala Thr
     130                 135                 140                
 Ser Ala Cys Thr Pro Ile Ser Ser Ser Lys Ser Asn Gly Leu Ser Lys
 145                 150                 155                 160
 Asp Met Asp Thr Gly Leu Gly Asp Ser Ile Cys Phe Ser Pro Ser Ile
                 165                 170                 175    
 Ser Ser Thr Thr Ser Pro Lys Leu Asn Pro Pro Pro Ser Pro His Ala
             180                 185                 190        
 Asn Lys Lys Lys His Leu Lys Lys Lys Ser Thr Asn Asn Phe Met Ile
         195                 200                 205            
 Val Ser Ala Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr Glu
     210                 215                 220                
 Glu Arg Asp Ala Trp Val Gln Ala Ile Gln Ser Gln Ile Leu Ala Ser
 225                 230                 235                 240
 Leu Gln Ser Cys Glu Ser Ser Lys Ser Lys Ser Gln Leu Thr Ser Gln
                 245                 250                 255    
 Ser Glu Ala Met Ala Leu Gln Ser Ile Gln Asn Met Arg Gly Asn Ala
             260                 265                 270        
 His Cys Val Asp Cys Glu Thr Gln Asn Pro Lys Trp Ala Ser Leu Asn
         275                 280                 285            
 Leu Gly Val Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Ser Leu
     290                 295                 300                
 Gly Pro His Leu Ser Arg Val Arg Ser Leu Glu Leu Asp Asp Trp Pro
 305                 310                 315                 320
 Val Glu Leu Arg Lys Val Met Ser Ser Ile Val Asn Asp Leu Ala Asn
                 325                 330                 335    
 Ser Ile Trp Glu Gly Ser Ser Gln Gly Gln Thr Lys Pro Ser Glu Lys
             340                 345                 350        
 Ser Thr Arg Glu Glu Lys Glu Arg Trp Ile Arg Ser Lys Tyr Glu Glu
         355                 360                 365            
 Lys Leu Phe Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly Gln
     370                 375                 380                
 Gln Leu Leu Arg Ala Thr Ala Asp Glu Asp Leu Gln Thr Ala Ile Leu
 385                 390                 395                 400
 Leu Leu Ala His Gly Ser Cys Glu Glu Val Asn Glu Thr Cys Gly Glu
                 405                 410                 415    
 Gly Asp Gly Cys Thr Ala Leu His Leu Ala Cys Arg Lys Gly Asn Val
             420                 425                 430        
 Val Leu Ala Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Met Ala Arg
         435                 440                 445            
 Asp Ala His Gly Asn Thr Ala Leu Thr Tyr Ala Arg Gln Ala Ser Ser
     450                 455                 460                
 Gln Glu Cys Ile Asn Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu Cys
 465                 470                 475                 480
 Val Xaa Tyr Leu Phe Tyr Leu Thr Ala Val Ser Leu Val Gln Lys Gln
                 485                 490                 495    
 Asn Gly Lys Asn Lys Asp Asn Ser Glu Phe Gln Lys Glu Ile Thr Asn
             500                 505                 510        
 Ser Ala Asn Asn Ser Ile Phe Ser Thr Phe Arg Lys Leu Ser Lys Tyr
         515                 520                 525            
 Thr Lys Cys
     530    



      <210> 2223
      <211> 138
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(138)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2223
 Gly Gly Phe Ala Ala Ala Val Glu Ser Phe His His Glu Asp Val Leu
   1               5                  10                  15    
 Leu Phe Ala Ala Leu Met Ala His Glu Leu Gly His Asn Leu Gly Ile
              20                  25                  30        
 Gln His Asp His Ser Ala Cys Phe Cys Lys Asp Lys His Phe Cys Leu
          35                  40                  45            
 Met His Glu Asn Ile Thr Lys Glu Ser Gly Phe Ser Ser Cys Ser Ser
      50                  55                  60                
 Asp Tyr Phe Tyr Gln Phe Leu Arg Glu His Lys Gly Ala Cys Leu Phe
  65                  70                  75                  80
 Asn Lys Pro Arg Pro Arg Gly Arg Lys Arg Arg Asp Ser Ala Cys Gly
                  85                  90                  95    
 Asn Gly Val Val Glu Asp Thr Asp Gln Cys Asp Cys Gly Ser Leu Cys
             100                 105                 110        
 Gln His His Ala Cys Cys Asp Glu Asn Cys Ile Leu Lys Ala Lys Ala
         115                 120                 125            
 Xaa Cys Asn Asp Gly Pro Cys Cys His Lys
     130                 135            



      <210> 2224
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 2224
 Met Arg Leu Ser Val Cys Leu Leu Leu Leu Thr Leu Ala Leu Cys Cys
   1               5                  10                  15    
 Tyr Arg Ala Asn Ala Val Val Cys Gln Ala Leu Gly Ser Glu Ile Thr
              20                  25                  30        
 Gly Phe Leu Leu Ala Gly Lys Pro Val Phe Lys Phe Gln Leu Ala Lys
          35                  40                  45            
 Phe Lys Ala Pro Leu Glu Ala Val Ala Ala Lys Met Glu Val Lys Lys
      50                  55                  60                
 Cys Val Asp Thr Met Ala Tyr Glu Lys Arg Val Leu Ile Thr Lys Thr
  65                  70                  75                  80
 Leu Gly Lys Ile Ala Glu Lys Cys Asp Arg
                  85                  90



      <210> 2225
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 2225
 Glu Ser Arg Glu Arg Ser Gly Asn Arg Arg Gly Ala Glu Asp Arg Gly
   1               5                  10                  15    
 Thr Cys Gly Leu Gln Ser Pro Ser Ala Met Leu Gly Ala Lys Pro His
              20                  25                  30        
 Trp Leu Pro Gly Pro Leu His Ser Pro Gly Leu Pro Leu Val Leu Val
          35                  40                  45            
 Leu Leu Ala Leu Gly Ala Gly Trp Ala Gln Glu Gly Ser Glu Pro Val
      50                  55                  60                
 Leu Leu Glu Gly Glu Cys Leu Val Val Cys Glu Pro Gly Arg Ala Ala
  65                  70                  75                  80
 Ala Gly Gly Pro Gly Gly Ala Ala Leu Gly Glu Ala Pro Pro Gly Arg
                  85                  90                  95    
 Val Ala Phe Ala Ala Val Arg Ser His His His Glu Pro Ala Gly Glu
             100                 105                 110        
 Thr Gly Asn Gly Thr Ser Gly Ala Ile Tyr Phe Asp Gln Val Leu Val
         115                 120                 125            
 Asn Glu Gly Gly Gly Phe Asp Arg Ala Ser
     130                 135            



      <210> 2226
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 2226
 Met Gly Cys Asp Gly Arg Val Ser Gly Leu Leu Arg Arg Asn Leu Gln
   1               5                  10                  15    
 Pro Thr Leu Thr Tyr Trp Ser Val Phe Phe Ser Phe Gly Leu Cys Ile
              20                  25                  30        
 Ala Phe Leu Gly Pro Thr Leu Leu Asp Leu Arg Cys Gln Thr His Ser
          35                  40                  45            
 Ser Leu Pro Gln Ile Ser Trp Val Phe Phe Ser Gln Gln Leu Cys Leu
      50                  55                  60                
 Leu Leu Gly Ser Ala Leu Gly Gly Val Phe Lys Arg Thr Leu Ala Gln
  65                  70                  75                  80
 Ser Leu Trp Ala Leu Phe Thr Ser Ser Leu Ala Ile Ser Leu Val Phe
                  85                  90                  95    
 Ala Val Ile Pro Phe Cys Arg Asp Val Lys Val Leu Ala Ser Val Met
             100                 105                 110        
 Ala Leu Ala Gly Leu Ala Met Gly Cys Ile Asp Thr Val Ala Asn Met
         115                 120                 125            
 Gln Leu Val Arg Met Tyr Gln Lys Asp Ser Ala Val Phe Leu Gln Val
     130                 135                 140                
 Leu His Phe Phe Val Gly Phe Gly Ala Leu Leu Ser Pro Leu Ile Ala
 145                 150                 155                 160
 Asp Pro Phe Leu Ser Glu Ala Asn Cys Leu Pro Ala Asn Ser Thr Gly
                 165                 170                 175    
 Gln His His Leu Pro Arg Ala Thr Cys Ser Met Ser Pro Gly Cys Trp
             180                 185                 190        
 Gly Gln His His Val Asp Ala Gln Ala Leu Val Gln Pro Asp Val Pro
         195                 200                 205            
 Lys Ala Asp Ser Gln Gly Pro Gly Arg Glu Pro Glu Gly Pro Met Pro
     210                 215                 220                
 Ser Gly
 225    



      <210> 2227
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 2227
 Met Gly Cys Asp Gly Arg Val Ser Gly Leu Leu Arg Arg Asn Leu Gln
   1               5                  10                  15    
 Pro Thr Leu Thr Tyr Trp Ser Val Phe Phe Ser Phe Gly Leu Cys Ile
              20                  25                  30        
 Ala Phe Leu Gly Pro Thr Leu Leu Asp Leu Arg Cys Gln Thr His Ser
          35                  40                  45            
 Ser Leu Pro Gln Ile Ser Trp Val Phe Phe Ser Gln Gln Leu Cys Leu
      50                  55                  60                
 Leu Leu Gly Ser Ala Leu Gly Gly Val Phe Lys Arg Thr Leu Ala Gln
  65                  70                  75                  80
 Ser Leu Trp Ala Leu Phe Thr Ser Ser Leu Ala Ile Ser Leu Val Phe
                  85                  90                  95    
 Ala Val Ile Pro Phe Cys Arg Asp Val Lys Val Leu Ala Ser Val Met
             100                 105                 110        
 Ala Leu Ala Gly Leu Ala Met Gly Cys Ile Asp Thr Val Ala Asn Met
         115                 120                 125            
 Gln Leu Val Arg Met Tyr Gln Lys Asp Ser Ala Val Phe Leu Gln Val
     130                 135                 140                
 Leu His Phe Phe Val Gly Phe Gly Ala Leu Leu Ser Pro Leu Ile Ala
 145                 150                 155                 160
 Asp Pro Phe Leu Ser Glu Ala Asn Cys Leu Pro Ala Asn Ser Thr Gly
                 165                 170                 175    
 Gln His His Leu Pro Arg Ala Thr Cys Ser Met Ser Pro Gly Cys Trp
             180                 185                 190        
 Gly Gln His His Val Asp Ala Gln Ala Leu Val Gln Pro Asp Val Pro
         195                 200                 205            
 Lys Ala Asp Ser Gln Gly Pro Gly Arg Glu Pro Glu Gly Pro Met Pro
     210                 215                 220                
 Ser Gly
 225    



      <210> 2228
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 2228
 Thr Gly Pro Thr Ile Lys Asn Met Asp Gly Thr Phe Asn Val Thr Ser
   1               5                  10                  15    
 Cys Leu Lys Leu Asn Ser Ser Gln Glu Asp Pro Gly Thr Val Tyr Gln
              20                  25                  30        
 Cys Val Val Arg His Ala Ser Leu His Thr Pro Leu Arg Ser Asn Phe
          35                  40                  45            
 Thr Leu Thr Ala Ala Arg His Ser Leu Ser Glu Thr Glu Lys Thr Asp
      50                  55                  60                
 Asn Phe Ser Ile His Trp Trp Pro Ile Ser Phe Ile Gly Val Gly Leu
  65                  70                  75                  80
 Val Leu Leu Ile Val Leu Ile Pro Trp Lys Lys Ile Cys Asn Lys Ser
                  85                  90                  95    
 Ser Ser Ala Tyr Thr Pro Leu Lys Cys Ile Leu Lys His Trp Asn Ser
             100                 105                 110        
 Phe Asp Thr Gln Thr Leu Lys Lys Glu His Leu Ile Phe Phe Cys Thr
         115                 120                 125            
 Arg Ala Trp Pro Ser Tyr Gln Leu Gln Asp Gly Glu Ala Trp Pro Pro
     130                 135                 140                
 Glu Gly Ser Val Asn Ile Asn Thr Tyr Ser Thr Thr Val
 145                 150                 155        



      <210> 2229
      <211> 551
      <212> PRT
      <213> Homo sapiens


      <400> 2229
 Gly Arg Gly Asp Ser Ser Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser
   1               5                  10                  15    
 Gly Ser Arg Ala Cys Pro Ala Arg Pro Ser Ala Pro Gly Leu Arg Ala
              20                  25                  30        
 Pro Thr Pro Pro Pro Arg Leu Pro Gly Ala Ser Gly Ala Pro Ala Ala
          35                  40                  45            
 Arg Leu Thr Leu Lys Phe Leu Ala Val Leu Leu Ala Ala Gly Met Leu
      50                  55                  60                
 Ala Phe Leu Gly Ala Val Ile Cys Ile Ile Ala Ser Val Pro Leu Ala
  65                  70                  75                  80
 Ala Ser Pro Ala Arg Ala Leu Pro Gly Gly Ala Asp Asn Ala Ser Val
                  85                  90                  95    
 Ala Ser Gly Ala Ala Ala Ser Pro Gly Pro Gln Arg Ser Leu Ser Ala
             100                 105                 110        
 Leu His Gly Ala Gly Gly Ser Ala Gly Pro Pro Ala Leu Pro Gly Ala
         115                 120                 125            
 Pro Ala Ala Ser Ala His Pro Leu Pro Pro Gly Pro Leu Phe Ser Arg
     130                 135                 140                
 Phe Leu Cys Thr Pro Leu Ala Ala Ala Cys Pro Ser Gly Ala Gln Gln
 145                 150                 155                 160
 Gly Asp Ala Ala Gly Ala Ala Pro Gly Glu Arg Glu Glu Leu Leu Leu
                 165                 170                 175    
 Leu Gln Ser Thr Ala Glu Gln Leu Arg Gln Thr Ala Leu Gln Gln Glu
             180                 185                 190        
 Ala Arg Ile Arg Ala Asp Gln Asp Thr Ile Arg Glu Leu Thr Gly Lys
         195                 200                 205            
 Leu Gly Arg Cys Glu Ser Gly Leu Pro Arg Gly Leu Gln Gly Ala Gly
     210                 215                 220                
 Pro Arg Arg Asp Thr Met Ala Asp Gly Pro Trp Asp Ser Pro Ala Leu
 225                 230                 235                 240
 Ile Leu Glu Leu Glu Asp Ala Val Arg Ala Leu Arg Asp Arg Ile Asp
                 245                 250                 255    
 Arg Leu Glu Glu Leu Pro Ala Arg Val Asn Leu Ser Ala Ala Pro Ala
             260                 265                 270        
 Pro Val Ser Ala Val Pro Thr Gly Leu His Ser Lys Met Asp Gln Leu
         275                 280                 285            
 Glu Gly Gln Leu Leu Ala Gln Val Leu Ala Leu Glu Lys Glu Arg Val
     290                 295                 300                
 Ala Leu Ser His Ser Ser Arg Arg Gln Arg Gln Glu Val Glu Lys Glu
 305                 310                 315                 320
 Leu Asp Val Leu Gln Gly Arg Val Ala Glu Leu Glu His Gly Ser Ser
                 325                 330                 335    
 Ala Tyr Ser Pro Pro Asp Ala Phe Lys Ile Ser Ile Pro Ile Arg Asn
             340                 345                 350        
 Asn Tyr Met Tyr Ala Arg Val Arg Lys Ala Leu Pro Glu Leu Tyr Ala
         355                 360                 365            
 Phe Thr Ala Cys Met Trp Leu Arg Ser Arg Ser Ser Gly Thr Gly Gln
     370                 375                 380                
 Gly Thr Pro Phe Ser Tyr Ser Val Pro Gly Gln Ala Gly Asn Glu Ile
 385                 390                 395                 400
 Val Leu Leu Glu Ala Gly His Glu Pro Met Glu Leu Leu Ile Asn Asp
                 405                 410                 415    
 Lys Val Ala Gln Leu Pro Leu Ser Leu Lys Asp Asn Gly Trp His His
             420                 425                 430        
 Ile Cys Ile Ala Trp Thr Thr Arg Asp Gly Leu Trp Ser Ala Tyr Gln
         435                 440                 445            
 Asp Gly Glu Leu Gln Gly Ser Gly Glu Asn Leu Ala Ala Trp His Pro
     450                 455                 460                
 Ile Lys Pro His Gly Ile Leu Ile Leu Gly Gln Glu Gln Asp Thr Leu
 465                 470                 475                 480
 Gly Gly Arg Phe Asp Ala Thr Gln Ala Phe Val Gly Asp Ile Ala Gln
                 485                 490                 495    
 Phe Asn Leu Trp Asp His Ala Leu Thr Pro Ala Gln Val Leu Gly Ile
             500                 505                 510        
 Ala Asn Cys Thr Ala Pro Leu Leu Gly Asn Val Leu Pro Trp Glu Asp
         515                 520                 525            
 Lys Leu Val Glu Ala Phe Gly Gly Ala Thr Lys Ala Ala Phe Asp Val
     530                 535                 540                
 Cys Lys Gly Arg Ala Lys Ala
 545                 550    



      <210> 2230
      <211> 303
      <212> PRT
      <213> Homo sapiens


      <400> 2230
 Phe Met Thr Asp Val Asn Ser Trp Leu Leu Thr Phe Gly Phe Gln Leu
   1               5                  10                  15    
 His Asn Val Ile Pro Gly Tyr Pro Lys Pro Asp Met Asp Ala Met Glu
              20                  25                  30        
 Pro Ser Tyr Glu Leu Ile His Thr Gln Met Lys Thr Gln Glu Trp Asp
          35                  40                  45            
 Asn Ser Lys Ser Ile Leu Gly Val Gln Cys Glu Val Gln Lys Gln Leu
      50                  55                  60                
 Lys Ala Phe Val Thr Leu Glu Arg Phe Asp Gln Leu Tyr Gly Ser Thr
  65                  70                  75                  80
 Ile Thr Ser Cys Gln Gln Ala Pro Lys Thr Lys Lys Phe Ala Ser Ser
                  85                  90                  95    
 Gly Ser Val Phe Gly Lys Gly Val Lys Phe Ala Leu Lys Asp Gly Arg
             100                 105                 110        
 Val Thr Thr Asp Ile Ile Ser Val Ala Asn Glu Asp Gly Arg Arg Val
         115                 120                 125            
 Ala Ala Ile Leu Asn His Ala His Tyr Leu Glu Asn Leu His Phe Thr
     130                 135                 140                
 Ile Asp Gly Val Asp Thr His Tyr Phe Val Lys Pro Gly Pro Ser Glu
 145                 150                 155                 160
 Gly Asp Leu Ala Ile Leu Gly Leu Ser Gly Gly Arg Arg Thr Leu Glu
                 165                 170                 175    
 Asn Gly Val Asn Val Thr Val Ser Gln Ile Asn Thr Val Leu Asn Gly
             180                 185                 190        
 Arg Thr Arg Arg Tyr Thr Asp Ile Gln Leu Gln Tyr Gly Ala Leu Cys
         195                 200                 205            
 Leu Asn Thr Arg Tyr Gly Thr Thr Leu Asp Glu Glu Lys Ala Arg Val
     210                 215                 220                
 Leu Glu Leu Ser Arg Gln Arg Ala Val Arg Gln Ala Trp Ala Arg Glu
 225                 230                 235                 240
 Gln Gln Arg Leu Arg Glu Gly Glu Glu Gly Leu Arg Ala Trp Thr Glu
                 245                 250                 255    
 Gly Glu Lys Gln Gln Val Leu Ser Thr Gly Arg Val Gln Gly Tyr Asp
             260                 265                 270        
 Gly Phe Phe Val Ile Ser Val Glu Gln Tyr Pro Glu Leu Ser Asp Ser
         275                 280                 285            
 Ala Asn Asn Ile His Phe Met Arg Gln Ser Glu Met Gly Arg Arg
     290                 295                 300            



      <210> 2231
      <211> 138
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(138)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2231
 Ala Ser Val Pro Lys Thr Asn Lys Ile Glu Pro Arg Ser Tyr Ser Ile
   1               5                  10                  15    
 Ile Pro Ser Cys Gly Ile Gln Ala Ala Arg Ala Cys Phe Glu His Ser
              20                  25                  30        
 Asn Phe Phe Lys Val Asn Ala Ser Gly Pro Ala Gly His Ser Ala Lys
          35                  40                  45            
 Ser Ile Glu Gly Ala Pro Arg Gly Lys Gly Arg Gly Arg Ala Val Ala
      50                  55                  60                
 Arg Leu Ala Ala Asp Arg Pro Pro Ala Pro Lys Ile Gln Leu Arg Ala
  65                  70                  75                  80
 Phe Xaa Leu Gln Gln Leu Xaa Tyr Thr Leu Leu Glu Leu Glu Leu Pro
                  85                  90                  95    
 Arg Leu Leu Ala Pro Asp Leu Pro Ser Asn Gly Ser Ser Leu Lys Asp
             100                 105                 110        
 Leu Lys Trp Thr His Ser Asn Tyr Arg Ala Ser Lys Glu Ser Cys Ile
         115                 120                 125            
 Val Ile Phe Arg His Tyr Leu Pro Gly Ser
     130                 135            



      <210> 2232
      <211> 61
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(61)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2232
 His Glu Arg Asp Val Leu Phe Asn Leu Cys Glu Asn Leu Val Lys Ser
   1               5                  10                  15    
 Ser Glu Ala Asn Ser Pro Ala His Glu Glu Phe Lys Thr Met Leu Leu
              20                  25                  30        
 Ile Ala His Tyr Tyr Ala Thr Arg Ser Ala Ala Glu Ser Val Tyr Gln
          35                  40                  45            
 Leu Xaa Ala Val Ser Arg Val Leu Leu Ser Leu Val Tyr
      50                  55                  60    



      <210> 2233
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 2233
 Lys Ile Lys Ala Lys Asn Leu Thr Asn Tyr Asp Leu Cys Ser Ile Phe
   1               5                  10                  15    
 Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly Val Ile Arg Tyr Leu
              20                  25                  30        
 Gly Tyr Phe Gln Ala Tyr Asn Val Leu Ile Leu Thr Met Gln Ala Ser
          35                  40                  45            
 Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala Gly Met Ile Tyr Leu
      50                  55                  60                
 Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp Lys
  65                  70                  75                  80
 Phe Glu Asn Leu Asn Thr Val Ala Glu Cys Leu Phe Ser Leu Val Asn
                  85                  90                  95    
 Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile Gln Gln Lys Ser Ile
             100                 105                 110        
 Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr Ser Phe Ile Ser Leu
         115                 120                 125            
 Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp Ser
     130                 135                 140                
 Tyr Asp Thr Ile Lys Lys Phe Gln Gln Asn Gly Phe Pro Glu Thr Asp
 145                 150                 155                 160
 Leu Gln Glu Phe
                



      <210> 2234
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 2234
 Lys Ile Lys Ala Lys Asn Leu Thr Asn Tyr Asp Leu Cys Ser Ile Phe
   1               5                  10                  15    
 Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly Val Ile Arg Tyr Leu
              20                  25                  30        
 Gly Tyr Phe Gln Ala Tyr Asn Val Leu Ile Leu Thr Met Gln Ala Ser
          35                  40                  45            
 Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala Gly Met Ile Tyr Leu
      50                  55                  60                
 Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp Lys
  65                  70                  75                  80
 Phe Glu Asn Leu Asn Thr Val Ala Glu Cys Leu Phe Ser Leu Val Asn
                  85                  90                  95    
 Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile Gln Gln Lys Ser Ile
             100                 105                 110        
 Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr Ser Phe Ile Ser Leu
         115                 120                 125            
 Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp Ser
     130                 135                 140                
 Tyr Asp Thr Ile Lys Lys Phe Gln Gln Asn Gly Phe Pro Glu Thr Asp
 145                 150                 155                 160
 Leu Gln Glu Phe
                



      <210> 2235
      <211> 191
      <212> PRT
      <213> Homo sapiens


      <400> 2235
 Pro Cys Gly Glu Phe His His Ser Ser Gln Lys Ala Thr Pro Ala Glu
   1               5                  10                  15    
 Glu Val Glu Asp Ser Asn Asp Ser Ser Tyr Ser Glu Pro Pro Asp Val
              20                  25                  30        
 Gln Gln Gln Leu Asn His Tyr Gln Ser Ala Ala Leu Ala Arg Asn Asn
          35                  40                  45            
 Ser Arg Val Ser Pro Val Pro Leu Ser Gly Ala Ala Ala Gly Thr Glu
      50                  55                  60                
 Gln Lys Thr Glu Ala Val Leu His Cys Glu Phe Cys Glu Phe Ser Ser
  65                  70                  75                  80
 Gly Tyr Ile Gln Ser Ile Arg Arg His Tyr Arg Asp Lys His Gly Gly
                  85                  90                  95    
 Lys Lys Leu Phe Lys Cys Lys Asp Cys Ser Phe Tyr Thr Gly Phe Lys
             100                 105                 110        
 Ser Ala Phe Thr Met His Val Glu Ala Gly His Ser Ala Val Pro Glu
         115                 120                 125            
 Glu Gly Pro Lys Asp Leu Arg Cys Pro Leu Cys Leu Tyr His Thr Lys
     130                 135                 140                
 Tyr Lys Arg Asn Met Ile Asp His Ile Val Leu His Arg Glu Glu Arg
 145                 150                 155                 160
 Val Val Pro Ile Glu Val Cys Arg Ser Lys Leu Ser Lys Tyr Leu Gln
                 165                 170                 175    
 Gly Val Val Phe Arg Cys Asp Lys Cys Thr Phe Thr Cys Ser Arg
             180                 185                 190    



      <210> 2236
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 2236
 Met Pro Leu Leu Glu Tyr Ala Arg Asn Met Leu Arg Thr Trp Ser Ser
   1               5                  10                  15    
 Leu Pro Trp Thr Arg Phe Arg Val Cys Leu Leu Ser Leu Ser Leu Phe
              20                  25                  30        
 Leu Trp Ala Asn Arg Leu Glu Asp Ser Arg Ser Cys Gln Pro Asn Pro
          35                  40                  45            
 Met Ser Leu Thr Thr Leu Pro Gly His Arg Leu Lys Glu Ala Val Trp
      50                  55                  60                
 Leu Pro Ala Pro Ser Arg Thr Met Ser Pro His Leu Asp Pro Asn Gln
  65                  70                  75                  80
 Leu Gly Ile Leu Leu Arg Val Leu Arg Lys Glu Lys Glu Asp Gly Asp
                  85                  90                  95    
 Tyr Pro Asp Met Met Ala Thr His Pro Ser Ser Arg Tyr Glu Ala Cys
             100                 105                 110        
 Ser Ser Gly Ile Thr Leu Ala Ala Pro Pro Thr His Gly Pro Arg Pro
         115                 120                 125            
 Thr Asp Pro Arg Ile Gly Pro Ala Pro
     130                 135        



      <210> 2237
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 2237
 Met Pro Leu Leu Glu Tyr Ala Arg Asn Met Leu Arg Thr Trp Ser Ser
   1               5                  10                  15    
 Leu Pro Trp Thr Arg Phe Arg Val Cys Leu Leu Ser Leu Ser Leu Phe
              20                  25                  30        
 Leu Trp Ala Asn Arg Leu Glu Asp Ser Arg Ser Cys Gln Pro Asn Pro
          35                  40                  45            
 Met Ser Leu Thr Thr Leu Pro Gly His Arg Leu Lys Glu Ala Val Trp
      50                  55                  60                
 Leu Pro Ala Pro Ser Arg Thr Met Ser Pro His Leu Asp Pro Asn Gln
  65                  70                  75                  80
 Leu Gly Ile Leu Leu Arg Val Leu Arg Lys Glu Lys Glu Asp Gly Asp
                  85                  90                  95    
 Tyr Pro Asp Met Met Ala Thr His Pro Ser Ser Arg Tyr Glu Ala Cys
             100                 105                 110        
 Ser Ser Gly Ile Thr Leu Ala Ala Pro Pro Thr His Gly Pro Arg Pro
         115                 120                 125            
 Thr Asp Pro Arg Ile Gly Pro Ala Pro
     130                 135        



      <210> 2238
      <211> 67
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(67)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2238
 Val Ser Asn Ile Val Asp Pro His Gln Thr Val Gly Leu Ser Thr Gln
   1               5                  10                  15    
 Glu Pro Gly Asp Ile Phe Thr Tyr Ser Glu Phe Asp Gly Ile Leu Gly
              20                  25                  30        
 Leu Ala Tyr Pro Ser Leu Ala Ser Glu Xaa Ser Val Pro Val Leu Asp
          35                  40                  45            
 Asn Thr Met Gln Arg His Leu Val Ala Gln Asp Leu Phe Ser Val Tyr
      50                  55                  60                
 Met Ser Arg
  65        



      <210> 2239
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 2239
 Asp Ser Arg Ile Pro Lys Glu Ala Pro Asp Gln Gln Lys Lys Lys Met
   1               5                  10                  15    
 Gly Pro Pro Ser Leu Val Leu Cys Leu Leu Ser Ala Thr Val Phe Ser
              20                  25                  30        
 Leu Leu Gly Gly Ser Ser Ala Phe Leu Ser His His Arg Leu Lys Gly
          35                  40                  45            
 Arg Phe Gln Arg Asp Arg Arg Asn Ile Arg Pro Asn Ile Ile Leu Val
      50                  55                  60                
 Leu Thr Asp Asp Gln Asp Val Glu Leu Gly Ser Met Gln Val Met Asn
  65                  70                  75                  80
 Lys Thr Arg Arg Ile Met Glu Gln Gly Gly Ala His Phe Ile Asn Ala
                  85                  90                  95    
 Phe Val Thr Thr Pro Met Cys Cys Pro Ser Arg Ser Ser Ile Leu Thr
             100                 105                 110        
 Gly Lys Tyr Val His Asn His Asn Thr Tyr Met Tyr
         115                 120                



      <210> 2240
      <211> 165
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(165)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2240
 Tyr Lys Glu Val Val Thr Gln His Phe Leu Xaa Val Thr Tyr Glu Thr
   1               5                  10                  15    
 His Pro Ile Tyr Tyr Leu Lys Ile Ser Gln Pro Ser Gly Asn Pro Lys
              20                  25                  30        
 Lys Ile Ile Trp Met Asp Cys Gly Ile His Ala Arg Glu Trp Ile Ala
          35                  40                  45            
 Pro Ala Phe Cys Gln Trp Phe Val Lys Glu Ile Leu Gln Asn His Lys
      50                  55                  60                
 Asp Asn Ser Arg Ile Arg Lys Leu Leu Met Asn Leu Asp Phe Tyr Val
  65                  70                  75                  80
 Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile Tyr Thr Trp Thr Thr Asp
                  85                  90                  95    
 Arg Leu Trp Arg Lys Ser Arg Ser Pro His Asn Asn Gly Thr Cys Phe
             100                 105                 110        
 Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala Ser Trp Cys Ser Ile Gly
         115                 120                 125            
 Ala Ser Arg Asn Cys Gln Asp Gln Thr Phe Cys Gly Thr Gly Pro Val
     130                 135                 140                
 Ser Glu Pro Glu Thr Lys Ala Val Ala Ser Phe Ile Glu Ser Lys Asn
 145                 150                 155                 160
 Asp Asp Phe Cys Ala
                 165



      <210> 2241
      <211> 165
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(165)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2241
 Tyr Lys Glu Val Val Thr Gln His Phe Leu Xaa Val Thr Tyr Glu Thr
   1               5                  10                  15    
 His Pro Ile Tyr Tyr Leu Lys Ile Ser Gln Pro Ser Gly Asn Pro Lys
              20                  25                  30        
 Lys Ile Ile Trp Met Asp Cys Gly Ile His Ala Arg Glu Trp Ile Ala
          35                  40                  45            
 Pro Ala Phe Cys Gln Trp Phe Val Lys Glu Ile Leu Gln Asn His Lys
      50                  55                  60                
 Asp Asn Ser Arg Ile Arg Lys Leu Leu Met Asn Leu Asp Phe Tyr Val
  65                  70                  75                  80
 Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile Tyr Thr Trp Thr Thr Asp
                  85                  90                  95    
 Arg Leu Trp Arg Lys Ser Arg Ser Pro His Asn Asn Gly Thr Cys Phe
             100                 105                 110        
 Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala Ser Trp Cys Ser Ile Gly
         115                 120                 125            
 Ala Ser Arg Asn Cys Gln Asp Gln Thr Phe Cys Gly Thr Gly Pro Val
     130                 135                 140                
 Ser Glu Pro Glu Thr Lys Ala Val Ala Ser Phe Ile Glu Ser Lys Asn
 145                 150                 155                 160
 Asp Asp Phe Cys Ala
                 165



      <210> 2242
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 2242
 Met Ala Ala Ala Gly Ala Gly Arg Leu Arg Arg Val Ala Ser Ala Leu
   1               5                  10                  15    
 Leu Leu Arg Ser Pro Arg Leu Pro Ala Arg Glu Leu Ser Ala Pro Ala
              20                  25                  30        
 Arg Leu Tyr His Lys Lys Val Val Asp His Tyr Glu Asn Pro Arg Asn
          35                  40                  45            
 Val Gly Ser Leu Asp Lys Thr Ser Lys Asn Val Gly Thr Gly Leu Val
      50                  55                  60                
 Gly Ala Pro Ala Cys Gly Asp Val Met Lys Leu Gln Ile Gln Val Asp
  65                  70                  75                  80
 Glu Lys Gly Lys Ile Val Asp Ala Arg Phe Lys Thr Phe Gly Cys Gly
                  85                  90                  95    
 Ser Ala Ile Ala Ser Ser Ser Leu Ala Thr Glu Trp Val Lys Gly Lys
             100                 105                 110        
 Thr Val Glu Glu Ala Leu Thr Ile Lys Asn Thr Asp Ile Ala Lys Glu
         115                 120                 125            
 Leu Cys Leu Pro Pro Val Lys Leu His Cys Ser Met Leu Ala Glu Asp
     130                 135                 140                
 Ala Ile Lys Ala Ala Leu Ala Asp Tyr Lys Leu Lys Gln Glu Pro Lys
 145                 150                 155                 160
 Lys Gly Glu Ala Glu Lys Lys
                 165        



      <210> 2243
      <211> 215
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(215)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2243
 Thr Gln Ala Trp Thr Arg Ala Glu Lys Asp Arg Lys Gly Ser Val Arg
   1               5                  10                  15    
 Ala Leu Arg Leu His Leu Glu Arg Gly Pro Pro Thr Xaa Arg Gly Ser
              20                  25                  30        
 His Pro Leu Gln Ser Val Pro Cys Ile Gln Lys Pro Ser Ile Phe Ser
          35                  40                  45            
 Ser Tyr Pro Ile Gly Leu Pro Gln Ser Gly Gly Glu Pro Gly Pro Val
      50                  55                  60                
 Gly Glu Gln Gln Pro Val Arg Arg Pro Glu Gln Pro Ser Cys Gly Pro
  65                  70                  75                  80
 Ala Ser Arg Met Pro Leu Thr Ser Arg Ser Val Pro Pro Gly Arg Gly
                  85                  90                  95    
 Ala Leu Pro Pro Asp Ser Leu Ser Thr Arg Lys Gly Leu Pro Arg Pro
             100                 105                 110        
 Ser Thr Ala Gly His Arg Val Arg Glu Ser Gly His Lys Val Pro Val
         115                 120                 125            
 Ser Gln Arg Leu Asn Leu Pro Val Met Gly Ala Thr Arg Ser Asn Leu
     130                 135                 140                
 Gln Pro Pro Arg Lys Val Ala Val Pro Gly Pro Thr Arg Xaa Arg Asp
 145                 150                 155                 160
 Gln Asp Ser Lys Gln Asp Phe Ser Ser Lys Pro Leu Gln Ser Val Pro
                 165                 170                 175    
 Gly Leu Ala Ser Thr Gln Gln Thr Leu Thr Pro Ala Asp Ser Gly Pro
             180                 185                 190        
 Gly Thr Gly Gly Arg Asp Ala Thr Arg Ala Gly Leu Pro Gly Val Glu
         195                 200                 205            
 Thr Met Gly Asn Gly Val Asp
     210                 215



      <210> 2244
      <211> 256
      <212> PRT
      <213> Homo sapiens


      <400> 2244
 Ser Leu Glu Met Ser Ser Asp Gly Glu Pro Leu Ser Arg Met Asp Ser
   1               5                  10                  15    
 Glu Asp Ser Ile Ser Ser Thr Ile Met Asp Val Asp Ser Thr Ile Ser
              20                  25                  30        
 Ser Gly Arg Ser Thr Pro Ala Met Met Asn Gly Gln Gly Ser Thr Thr
          35                  40                  45            
 Ser Ser Ser Lys Asn Ile Ala Tyr Asn Cys Cys Trp Asp Gln Cys Gln
      50                  55                  60                
 Ala Cys Phe Asn Ser Ser Pro Asp Leu Ala Asp His Ile Arg Ser Ile
  65                  70                  75                  80
 His Val Asp Gly Gln Arg Gly Gly Val Phe Val Cys Leu Trp Lys Gly
                  85                  90                  95    
 Cys Lys Val Tyr Asn Thr Pro Ser Thr Ser Gln Ser Trp Leu Gln Arg
             100                 105                 110        
 His Met Leu Thr His Ser Gly Asp Lys Pro Phe Lys Cys Val Val Gly
         115                 120                 125            
 Gly Cys Asn Ala Ser Phe Ala Ser Gln Gly Gly Leu Ala Arg His Val
     130                 135                 140                
 Pro Thr His Phe Ser Gln Gln Asn Ser Ser Lys Val Ser Ser Gln Pro
 145                 150                 155                 160
 Lys Ala Lys Glu Glu Ser Pro Ser Lys Ala Gly Met Asn Lys Arg Arg
                 165                 170                 175    
 Lys Leu Lys Asn Lys Arg Arg Arg Ser Leu Ala Arg Pro His Asp Phe
             180                 185                 190        
 Phe Asp Ala Gln Thr Leu Asp Ala Ile Arg His Arg Ala Ile Cys Phe
         195                 200                 205            
 Asn Leu Ser Ala His Ile Glu Ser Leu Gly Lys Gly His Ser Val Val
     210                 215                 220                
 Phe His Ser Thr Val Ser Ile Leu Leu Phe Phe Gln Ile Lys Tyr Lys
 225                 230                 235                 240
 Thr Leu Gln Lys Asn Ile Ser Thr Ile Ile Ser Lys Ser Leu Lys Ile
                 245                 250                 255    





      <210> 2245
      <211> 587
      <212> PRT
      <213> Homo sapiens


      <400> 2245
 Gly Ala Arg Gly Arg Pro Leu Ala Glu Thr Trp Pro Phe Leu Thr Ala
   1               5                  10                  15    
 Pro Val Leu Pro Gly Gln Leu Gln Ile Thr Glu Pro Thr Met Ala Glu
              20                  25                  30        
 Lys Gly Asp Cys Ile Ala Ser Val Tyr Gly Tyr Asp Leu Gly Gly Arg
          35                  40                  45            
 Phe Val Asp Phe Gln Pro Leu Gly Phe Gly Val Asn Gly Leu Val Leu
      50                  55                  60                
 Ser Ala Val Asp Ser Arg Ala Cys Arg Lys Val Ala Val Lys Lys Ile
  65                  70                  75                  80
 Ala Leu Ser Asp Ala Arg Ser Met Lys His Ala Leu Arg Glu Ile Lys
                  85                  90                  95    
 Ile Ile Arg Arg Leu Asp His Asp Asn Ile Val Lys Val Tyr Glu Val
             100                 105                 110        
 Leu Gly Pro Lys Gly Thr Asp Leu Gln Gly Glu Leu Phe Lys Phe Ser
         115                 120                 125            
 Val Ala Tyr Ile Val Gln Glu Tyr Met Glu Thr Asp Leu Ala Arg Leu
     130                 135                 140                
 Leu Glu Gln Gly Thr Leu Ala Glu Glu His Ala Lys Leu Phe Met Tyr
 145                 150                 155                 160
 Gln Leu Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn Val Leu His
                 165                 170                 175    
 Arg Asp Leu Lys Pro Ala Asn Ile Phe Ile Ser Thr Glu Asp Leu Val
             180                 185                 190        
 Leu Lys Ile Gly Asp Phe Gly Leu Ala Arg Ile Val Asp Gln His Tyr
         195                 200                 205            
 Ser His Lys Gly Tyr Leu Ser Glu Gly Leu Val Thr Lys Trp Tyr Arg
     210                 215                 220                
 Ser Pro Arg Leu Leu Leu Ser Pro Asn Asn Tyr Thr Lys Ala Ile Asp
 225                 230                 235                 240
 Met Trp Ala Ala Gly Cys Ile Leu Ala Glu Met Leu Thr Gly Arg Met
                 245                 250                 255    
 Leu Phe Ala Gly Ala His Glu Leu Glu Gln Met Gln Leu Ile Leu Glu
             260                 265                 270        
 Thr Ile Pro Val Ile Arg Glu Glu Asp Lys Asp Glu Leu Leu Arg Val
         275                 280                 285            
 Met Pro Ser Phe Val Ser Ser Thr Trp Glu Val Lys Arg Pro Leu Arg
     290                 295                 300                
 Lys Leu Leu Pro Glu Val Asn Ser Glu Ala Ile Asp Phe Leu Glu Lys
 305                 310                 315                 320
 Ile Leu Thr Phe Asn Pro Met Asp Arg Leu Thr Ala Glu Met Gly Leu
                 325                 330                 335    
 Gln His Pro Tyr Met Ser Pro Tyr Ser Cys Pro Glu Asp Glu Pro Thr
             340                 345                 350        
 Ser Gln His Pro Phe Arg Ile Glu Asp Glu Ile Asp Asp Ile Val Leu
         355                 360                 365            
 Met Ala Ala Asn Gln Ser Gln Leu Ser Asn Trp Asp Thr Cys Ser Ser
     370                 375                 380                
 Arg Tyr Pro Val Ser Leu Ser Ser Asp Leu Glu Trp Arg Pro Asp Arg
 385                 390                 395                 400
 Cys Gln Asp Ala Ser Glu Val Gln Arg Asp Pro Arg Ala Gly Ser Ala
                 405                 410                 415    
 Pro Leu Ala Glu Asn Val Gln Val Asp Pro Arg Lys Asp Ser His Ser
             420                 425                 430        
 Ser Ser Glu Arg Phe Leu Glu Gln Ser His Ser Ser Met Glu Arg Ala
         435                 440                 445            
 Phe Glu Ala Asp Tyr Gly Arg Ser Cys Asp Tyr Lys Val Gly Ser Pro
     450                 455                 460                
 Ser Tyr Leu Asp Lys Leu Leu Trp Arg Asp Asn Lys Pro His His Tyr
 465                 470                 475                 480
 Ser Glu Pro Lys Leu Ile Leu Asp Leu Ser His Trp Lys Gln Ala Ala
                 485                 490                 495    
 Gly Ala Pro Pro Thr Ala Thr Gly Leu Ala Asp Thr Gly Ala Arg Glu
             500                 505                 510        
 Asp Glu Pro Ala Ser Leu Phe Leu Glu Ile Ala Gln Trp Val Lys Ser
         515                 520                 525            
 Thr Gln Gly Ala Gln Ser Thr Pro Ala Arg Pro Pro Thr Thr Pro Ser
     530                 535                 540                
 Ala Ala Cys Leu Pro Arg Pro Pro Pro Pro Gly Pro Gly Gly Cys Arg
 545                 550                 555                 560
 Arg Gln Pro Pro Val Arg Pro Gly Arg Val His Leu Pro Arg Pro Glu
                 565                 570                 575    
 Ala Leu His Gln Ala Arg Gly Pro Ala Gly Gln
             580                 585        



      <210> 2246
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 2246
 Val Ile Glu Trp Val Val Pro Val Glu Pro Pro Asn Gln Leu Ser Thr
   1               5                  10                  15    
 Ser Ser Val Gly Arg Val Pro Gly Ser Thr Arg Pro Gln Arg Ser Phe
              20                  25                  30        
 Leu Ser Arg Val Val Arg Ala Ala Leu Pro Leu Gln Leu Leu Leu Leu
          35                  40                  45            
 Leu Leu Leu Leu Leu Ala Cys Leu Leu Pro Ser Ser Glu Glu Asp Tyr
      50                  55                  60                
 Ser Cys Thr Gln Ala Asn Asn Phe Ala Arg Ser Phe Tyr Pro Met Leu
  65                  70                  75                  80
 Arg Tyr Thr Asn Gly Pro Pro Pro Thr
                  85                



      <210> 2247
      <211> 87
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(87)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2247
 Ser Ser Phe Ile Lys Arg His Ile Leu Ile Phe Glu Asp Asp Trp His
   1               5                  10                  15    
 Gln Thr Thr Cys Cys His His Pro His His Pro Phe Xaa Arg Cys Gln
              20                  25                  30        
 Phe His Ile Phe Tyr Val Ser Val Gln Asn Ser Ile Ser Pro Ser Leu
          35                  40                  45            
 Ser Val Ser Ser Ser His Pro Asp Arg Pro Asp His Glu Val His Gln
      50                  55                  60                
 His Arg Ala Ala His His His Gln His Gly Gln Gly Pro Leu Gly His
  65                  70                  75                  80
 Gly Leu Val Ala Arg Val Gly
                  85        



      <210> 2248
      <211> 135
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(135)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2248
 Gly Xaa Ala Gly Val Gly Gly Asp Ser Glu Gly Glu Val Thr Ser Ala
   1               5                  10                  15    
 Leu Ser Ala Thr Phe Ser Gly Pro Lys Ile Ala Phe Tyr Val Gly Leu
              20                  25                  30        
 Lys Ser Pro His Glu Gly Tyr Glu Val Leu Lys Phe Asp Asp Val Val
          35                  40                  45            
 Thr Asn Leu Gly Asn His Tyr Asp Pro Thr Thr Gly Lys Phe Ser Cys
      50                  55                  60                
 Gln Val Arg Gly Ile Tyr Phe Phe Thr Tyr His Ile Leu Met Arg Gly
  65                  70                  75                  80
 Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Cys Lys Asn Gly Gln Val
                  85                  90                  95    
 Arg Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln Asn Tyr Asp Tyr Ala
             100                 105                 110        
 Ser Asn Ser Val Val Leu His Leu Asp Ser Gly Asp Glu Val Tyr Val
         115                 120                 125            
 Lys Leu Asp Gly Gly Lys Ala
     130                 135



      <210> 2249
      <211> 232
      <212> PRT
      <213> Homo sapiens


      <400> 2249
 Arg Arg Tyr Lys Ser Gly Thr Glu Val Asn Asn Thr Asp Gly Gly Ile
   1               5                  10                  15    
 Ala Arg Leu Ile Val Phe Gly Thr Gly Gln Lys Asp Trp Thr Ala Thr
              20                  25                  30        
 Asp Pro Lys Glu Pro Ala Asp Leu Val Ala Ile Ala Phe Gly Gly Val
          35                  40                  45            
 Cys Val Gly Phe Ser Asn Ala Lys Phe Gly His Pro Asn Asn Ile Ile
      50                  55                  60                
 Gly Val Gly Gly Ala Lys Ser Met Ala Asp Gly Trp Glu Thr Ala Arg
  65                  70                  75                  80
 Arg Leu Asp Arg Pro Pro Ile Leu Glu Asn Asp Glu Asn Gly Ile Leu
                  85                  90                  95    
 Leu Val Pro Gly Cys Glu Trp Ala Val Phe Arg Leu Ala His Pro Gly
             100                 105                 110        
 Val Ile Thr Arg Ile Glu Ile Asp Thr Lys Tyr Phe Glu Gly Asn Ala
         115                 120                 125            
 Pro Asp Ser Cys Lys Val Asp Gly Cys Ile Leu Thr Thr Gln Glu Glu
     130                 135                 140                
 Ala Val Ile Arg Gln Lys Trp Ile Leu Pro Ala His Lys Trp Lys Pro
 145                 150                 155                 160
 Leu Leu Pro Val Thr Lys Leu Ser Pro Asn Gln Ser His Leu Phe Asp
                 165                 170                 175    
 Ser Leu Thr Leu Glu Leu Gln Asp Val Ile Thr His Ala Arg Leu Thr
             180                 185                 190        
 Ile Val Pro Asp Gly Gly Val Asn Arg Leu Arg Leu Arg Gly Phe Pro
         195                 200                 205            
 Ser Ser Ile Cys Leu Leu Arg Pro Arg Glu Lys Pro Met Leu Lys Phe
     210                 215                 220                
 Ser Val Ser Phe Lys Ala Asn Pro
 225                 230        



      <210> 2250
      <211> 539
      <212> PRT
      <213> Homo sapiens


      <400> 2250
 Pro Pro Phe Gly Gly Leu Ser Ala Ala Gln Thr Ile Gly Glu Met Trp
   1               5                  10                  15    
 Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp Val Ala
              20                  25                  30        
 Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val Trp Ala
          35                  40                  45            
 Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile Pro Leu
      50                  55                  60                
 Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln His Gln
  65                  70                  75                  80
 Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu Ala Pro
                  85                  90                  95    
 Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro Arg Arg
             100                 105                 110        
 Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly Arg Leu
         115                 120                 125            
 Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln Arg Gly
     130                 135                 140                
 Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala Gly Glu
 145                 150                 155                 160
 Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys Arg Leu
                 165                 170                 175    
 Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro Gly Ser
             180                 185                 190        
 Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser Arg Pro
         195                 200                 205            
 Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln Gly Arg
     210                 215                 220                
 Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser Phe Leu
 225                 230                 235                 240
 Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly Cys Ile
                 245                 250                 255    
 Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn Leu Thr
             260                 265                 270        
 Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala Gly Ala
         275                 280                 285            
 Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val Gly Thr
     290                 295                 300                
 Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro Asp
 305                 310                 315                 320
 Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu Glu Asp
                 325                 330                 335    
 Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His Leu Gln
             340                 345                 350        
 Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr Val Thr
         355                 360                 365            
 Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu Cys Glu
     370                 375                 380                
 Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser Leu Asp
 385                 390                 395                 400
 Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala Gln Glu
                 405                 410                 415    
 Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln Gly Glu
             420                 425                 430        
 Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser Pro Gly
         435                 440                 445            
 Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly His Leu
     450                 455                 460                
 Leu Leu Phe Leu Thr Leu Gly Val Leu Ser Leu Leu Leu Leu Val Thr
 465                 470                 475                 480
 Gly Thr Phe Gly Phe His Leu Trp Arg Arg Gln Cys Arg Pro Arg Arg
                 485                 490                 495    
 Phe Ser Ala Leu Glu Gln Gly Ile His Pro Arg Gln Ala Gln Ser Lys
             500                 505                 510        
 Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro
         515                 520                 525            
 Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu
     530                 535                



      <210> 2251
      <211> 1257
      <212> PRT
      <213> Homo sapiens


      <400> 2251
 Ser Trp Pro Arg Gly Arg Gly Glu Thr Gly Gly His Pro Gly Ala Leu
   1               5                  10                  15    
 Arg Thr Arg Thr Met Gln Lys Ser Val Arg Tyr Asn Glu Gly His Ala
              20                  25                  30        
 Leu Tyr Leu Ala Phe Leu Ala Arg Lys Glu Gly Thr Lys Arg Gly Phe
          35                  40                  45            
 Leu Ser Lys Lys Thr Ala Glu Ala Ser Arg Trp His Glu Lys Trp Phe
      50                  55                  60                
 Ala Leu Tyr Gln Asn Val Leu Phe Tyr Phe Glu Gly Glu Gln Ser Cys
  65                  70                  75                  80
 Arg Pro Ala Gly Met Tyr Leu Leu Glu Gly Cys Ser Cys Glu Arg Thr
                  85                  90                  95    
 Pro Ala Pro Pro Arg Ala Gly Ala Gly Gln Gly Gly Val Arg Asp Ala
             100                 105                 110        
 Leu Asp Lys Gln Tyr Tyr Phe Thr Val Leu Phe Gly His Glu Gly Gln
         115                 120                 125            
 Lys Pro Leu Glu Leu Arg Cys Glu Glu Glu Gln Asp Gly Lys Glu Trp
     130                 135                 140                
 Met Glu Ala Ile His Gln Ala Ser Tyr Ala Asp Ile Leu Ile Glu Arg
 145                 150                 155                 160
 Glu Val Leu Met Gln Lys Tyr Ile His Leu Val Gln Ile Val Glu Thr
                 165                 170                 175    
 Glu Lys Ile Ala Ala Asn Gln Leu Arg His Gln Leu Glu Asp Gln Asp
             180                 185                 190        
 Thr Glu Ile Glu Arg Leu Lys Ser Glu Ile Ile Ala Leu Asn Lys Thr
         195                 200                 205            
 Lys Glu Arg Met Arg Pro Tyr Gln Ser Asn Gln Glu Asp Glu Asp Pro
     210                 215                 220                
 Asp Ile Lys Lys Ile Lys Lys Val Gln Ser Phe Met Arg Gly Trp Leu
 225                 230                 235                 240
 Cys Arg Arg Lys Trp Lys Thr Ile Val Gln Asp Tyr Ile Cys Ser Pro
                 245                 250                 255    
 His Ala Glu Ser Met Arg Lys Arg Asn Gln Ile Val Phe Thr Met Val
             260                 265                 270        
 Glu Ala Glu Ser Glu Tyr Val His Gln Leu Tyr Ile Leu Val Asn Gly
         275                 280                 285            
 Phe Leu Arg Pro Leu Arg Met Ala Ala Ser Ser Lys Lys Pro Pro Ile
     290                 295                 300                
 Ser His Asp Asp Val Ser Ser Ile Phe Leu Asn Ser Glu Thr Ile Met
 305                 310                 315                 320
 Phe Leu His Glu Ile Phe His Gln Gly Leu Lys Ala Arg Ile Ala Asn
                 325                 330                 335    
 Trp Pro Thr Leu Ile Leu Ala Asp Leu Phe Asp Ile Leu Leu Pro Met
             340                 345                 350        
 Leu Asn Ile Tyr Gln Glu Phe Val Arg Asn His Gln Tyr Ser Leu Gln
         355                 360                 365            
 Val Leu Ala Asn Cys Lys Gln Asn Arg Asp Phe Asp Lys Leu Leu Lys
     370                 375                 380                
 Gln Tyr Glu Ala Asn Pro Ala Cys Glu Gly Arg Met Leu Glu Thr Phe
 385                 390                 395                 400
 Leu Thr Tyr Pro Met Phe Gln Ile Pro Arg Tyr Ile Ile Thr Leu His
                 405                 410                 415    
 Glu Leu Leu Ala His Thr Pro His Glu His Val Glu Arg Lys Ser Leu
             420                 425                 430        
 Glu Phe Ala Lys Ser Lys Leu Glu Glu Leu Ser Arg Val Met His Asp
         435                 440                 445            
 Glu Val Ser Asp Thr Glu Asn Ile Arg Lys Asn Leu Ala Ile Glu Arg
     450                 455                 460                
 Met Ile Val Glu Gly Cys Asp Ile Leu Leu Asp Thr Ser Gln Thr Phe
 465                 470                 475                 480
 Ile Arg Gln Gly Ser Leu Ile Gln Val Pro Ser Val Glu Arg Gly Lys
                 485                 490                 495    
 Leu Ser Lys Val Arg Leu Gly Ser Leu Ser Leu Lys Lys Glu Gly Glu
             500                 505                 510        
 Arg Gln Cys Phe Leu Phe Thr Lys His Phe Leu Ile Cys Thr Arg Ser
         515                 520                 525            
 Ser Gly Gly Lys Leu His Leu Leu Lys Thr Gly Gly Val Leu Ser Leu
     530                 535                 540                
 Ile Asp Cys Thr Leu Ile Glu Glu Pro Asp Ala Ser Asp Asp Asp Ser
 545                 550                 555                 560
 Lys Gly Ser Gly Gln Val Phe Gly His Leu Asp Phe Lys Ile Val Val
                 565                 570                 575    
 Glu Pro Pro Asp Arg Ala Ala Phe Thr Val Val Leu Leu Ala Pro Ser
             580                 585                 590        
 Arg Gln Glu Lys Ala Ala Trp Met Ser Asp Ile Ser Gln Cys Val Asp
         595                 600                 605            
 Asn Ile Arg Cys Asn Gly Leu Met Thr Ile Val Phe Glu Glu Asn Ser
     610                 615                 620                
 Lys Val Thr Val Pro His Met Ile Lys Ser Asp Ala Arg Leu His Lys
 625                 630                 635                 640
 Asp Asp Thr Asp Ile Cys Phe Ser Lys Thr Leu Asn Ser Cys Lys Val
                 645                 650                 655    
 Pro Gln Ile Arg Tyr Ala Ser Val Glu Arg Leu Leu Glu Arg Leu Thr
             660                 665                 670        
 Asp Leu Arg Phe Leu Ser Ile Asp Phe Leu Asn Thr Phe Leu His Thr
         675                 680                 685            
 Tyr Arg Ile Phe Thr Thr Ala Ala Val Val Leu Gly Lys Leu Ser Asp
     690                 695                 700                
 Ile Tyr Lys Arg Pro Phe Thr Ser Ile Pro Val Arg Ser Leu Glu Leu
 705                 710                 715                 720
 Phe Phe Ala Thr Ser Gln Asn Asn Arg Gly Glu His Leu Val Asp Gly
                 725                 730                 735    
 Lys Ser Pro Arg Leu Cys Arg Lys Phe Ser Ser Pro Pro Pro Leu Ala
             740                 745                 750        
 Val Ser Arg Thr Ser Ser Pro Val Arg Ala Arg Lys Leu Ser Leu Thr
         755                 760                 765            
 Ser Pro Leu Asn Ser Lys Ile Gly Ala Leu Asp Leu Thr Thr Ser Ser
     770                 775                 780                
 Ser Pro Thr Thr Thr Thr Gln Ser Pro Ala Ala Ser Pro Pro Pro His
 785                 790                 795                 800
 Thr Gly Gln Ile Pro Leu Asp Leu Ser Arg Gly Leu Ser Ser Pro Glu
                 805                 810                 815    
 Gln Ser Pro Gly Thr Val Glu Glu Asn Val Asp Asn Pro Arg Val Asp
             820                 825                 830        
 Leu Cys Asn Lys Leu Lys Arg Ser Ile Gln Lys Ala Val Leu Glu Ser
         835                 840                 845            
 Ala Pro Ala Asp Arg Ala Gly Val Glu Ser Ser Pro Ala Ala Asp Thr
     850                 855                 860                
 Thr Glu Leu Ser Pro Cys Arg Ser Pro Ser Thr Pro Arg His Leu Arg
 865                 870                 875                 880
 Tyr Arg Gln Pro Gly Gly Gln Thr Ala Asp Asn Ala His Cys Ser Val
                 885                 890                 895    
 Ser Pro Ala Ser Ala Phe Ala Ile Ala Thr Ala Ala Ala Gly His Gly
             900                 905                 910        
 Ser Pro Pro Gly Phe Asn Asn Thr Glu Arg Thr Cys Asp Lys Glu Phe
         915                 920                 925            
 Ile Ile Arg Arg Thr Ala Thr Asn Arg Val Leu Asn Val Leu Arg His
     930                 935                 940                
 Trp Val Ser Lys His Ala Gln Asp Phe Glu Leu Asn Asn Glu Leu Lys
 945                 950                 955                 960
 Met Asn Val Leu Asn Leu Leu Glu Glu Val Leu Arg Asp Pro Asp Leu
                 965                 970                 975    
 Leu Pro Gln Glu Arg Lys Ala Ala Ala Asn Ile Leu Met Ala Leu Ser
             980                 985                 990        
 Gln Asp Asp Gln Asp Asp Ile His Leu Lys Leu Glu Asp Ile Ile Gln
         995                1000                1005            
 Met Thr Asp Cys Met Lys Ala Glu Cys Phe Glu Ser Leu Ser Ala Met
    1010                1015                1020                
 Glu Leu Ala Glu Gln Ile Thr Leu Leu Asp His Val Ile Phe Arg Ser
1025                1030                1035                1040
 Ile Pro Tyr Glu Glu Phe Leu Gly Gln Gly Trp Met Lys Leu Asp Lys
                1045                1050                1055    
 Asn Glu Arg Thr Pro Tyr Ile Met Lys Thr Ser Gln His Phe Asn Asp
            1060                1065                1070        
 Met Ser Asn Leu Val Ala Ser Gln Ile Met Asn Tyr Ala Asp Val Ser
        1075                1080                1085            
 Ser Arg Ala Asn Ala Ile Glu Lys Trp Val Ala Val Ala Asp Ile Cys
    1090                1095                1100                
 Arg Cys Leu His Asn Tyr Asn Gly Val Leu Glu Ile Thr Ser Ala Leu
1105                1110                1115                1120
 Asn Arg Ser Ala Ile Tyr Arg Leu Lys Lys Thr Trp Ala Lys Val Ser
                1125                1130                1135    
 Lys Gln Thr Lys Ala Leu Met Asp Lys Leu Gln Lys Thr Val Ser Ser
            1140                1145                1150        
 Glu Gly Arg Phe Lys Asn Leu Arg Glu Thr Leu Lys Asn Cys Asn Pro
        1155                1160                1165            
 Pro Ala Val Pro Tyr Leu Gly Met Tyr Leu Thr Asp Leu Ala Phe Ile
    1170                1175                1180                
 Glu Glu Gly Thr Pro Asn Phe Thr Glu Glu Gly Leu Val Asn Phe Ser
1185                1190                1195                1200
 Lys Met Arg Met Ile Ser His Ile Ile Arg Glu Ile Arg Gln Phe Gln
                1205                1210                1215    
 Gln Thr Ser Tyr Arg Ile Asp His Gln Pro Lys Val Ala Gln Tyr Leu
            1220                1225                1230        
 Leu Asp Lys Asp Leu Ile Ile Asp Glu Asp Thr Leu Tyr Glu Leu Ser
        1235                1240                1245            
 Leu Lys Ile Glu Pro Arg Leu Pro Ala
    1250                1255        



      <210> 2252
      <211> 1534
      <212> PRT
      <213> Homo sapiens


      <400> 2252
 Ala Ser Gly Asn Leu Asp Lys Asn Ala Arg Phe Ser Ala Ile Tyr Arg
   1               5                  10                  15    
 Gln Asp Ser Asn Lys Leu Ser Asn Asp Asp Met Leu Lys Leu Leu Ala
              20                  25                  30        
 Asp Phe Arg Lys Pro Glu Lys Met Ala Lys Leu Pro Val Ile Leu Gly
          35                  40                  45            
 Asn Leu Asp Ile Thr Ile Asp Asn Val Ser Ser Asp Phe Pro Asn Tyr
      50                  55                  60                
 Val Asn Ser Ser Tyr Ile Pro Thr Lys Gln Phe Glu Thr Cys Ser Lys
  65                  70                  75                  80
 Thr Pro Ile Thr Phe Glu Val Glu Glu Phe Val Pro Cys Ile Pro Lys
                  85                  90                  95    
 His Thr Gln Pro Tyr Thr Ile Tyr Thr Asn His Leu Tyr Val Tyr Pro
             100                 105                 110        
 Lys Tyr Leu Lys Tyr Asp Ser Gln Lys Ser Phe Ala Lys Ala Arg Asn
         115                 120                 125            
 Ile Ala Ile Cys Ile Glu Phe Lys Asp Ser Asp Glu Glu Asp Ser Gln
     130                 135                 140                
 Pro Leu Lys Cys Ile Tyr Gly Arg Pro Gly Gly Pro Val Phe Thr Arg
 145                 150                 155                 160
 Ser Ala Phe Ala Ala Val Leu His His His Gln Asn Pro Glu Phe Tyr
                 165                 170                 175    
 Asp Glu Ile Lys Ile Glu Leu Pro Thr Gln Leu His Glu Lys His His
             180                 185                 190        
 Leu Leu Leu Thr Phe Phe His Val Ser Cys Asp Asn Ser Ser Lys Gly
         195                 200                 205            
 Ser Thr Lys Lys Arg Asp Val Val Glu Thr Gln Val Gly Tyr Ser Trp
     210                 215                 220                
 Leu Pro Leu Leu Lys Asp Gly Arg Val Val Thr Ser Glu Gln His Ile
 225                 230                 235                 240
 Pro Val Ser Ala Asn Leu Pro Ser Gly Tyr Leu Gly Tyr Gln Glu Leu
                 245                 250                 255    
 Gly Met Gly Arg His Tyr Gly Pro Glu Ile Lys Trp Val Asp Gly Gly
             260                 265                 270        
 Lys Pro Leu Leu Lys Ile Ser Thr His Leu Val Ser Thr Val Tyr Thr
         275                 280                 285            
 Gln Asp Gln His Leu His Asn Phe Phe Gln Tyr Cys Gln Lys Thr Glu
     290                 295                 300                
 Ser Gly Ala Gln Ala Leu Gly Asn Glu Leu Val Lys Tyr Leu Lys Ser
 305                 310                 315                 320
 Leu His Ala Met Glu Gly His Val Met Ile Ala Phe Leu Pro Thr Ile
                 325                 330                 335    
 Leu Asn Gln Leu Phe Arg Val Leu Thr Arg Ala Thr Gln Glu Glu Val
             340                 345                 350        
 Ala Val Asn Val Thr Arg Val Ile Ile His Val Val Ala Gln Cys His
         355                 360                 365            
 Glu Glu Gly Leu Glu Ser His Leu Arg Ser Tyr Val Lys Tyr Ala Tyr
     370                 375                 380                
 Lys Ala Glu Pro Tyr Val Ala Ser Glu Tyr Lys Thr Val His Glu Glu
 385                 390                 395                 400
 Leu Thr Lys Ser Met Thr Thr Ile Leu Lys Pro Ser Ala Asp Phe Leu
                 405                 410                 415    
 Thr Ser Asn Lys Leu Leu Lys Tyr Ser Trp Phe Phe Phe Asp Val Leu
             420                 425                 430        
 Ile Lys Ser Met Ala Gln His Leu Ile Glu Asn Ser Lys Val Lys Leu
         435                 440                 445            
 Leu Arg Asn Gln Arg Phe Pro Ala Ser Tyr His His Ala Val Glu Thr
     450                 455                 460                
 Val Val Asn Met Leu Met Pro His Ile Thr Gln Lys Phe Arg Asp Asn
 465                 470                 475                 480
 Pro Glu Ala Ser Lys Asn Ala Asn His Ser Leu Ala Val Phe Ile Lys
                 485                 490                 495    
 Arg Cys Phe Thr Phe Met Asp Arg Gly Phe Val Phe Lys Gln Ile Asn
             500                 505                 510        
 Asn Tyr Ile Ser Cys Phe Ala Pro Gly Asp Pro Lys Thr Leu Phe Glu
         515                 520                 525            
 Tyr Lys Phe Glu Phe Leu Arg Val Val Cys Asn His Glu His Tyr Ile
     530                 535                 540                
 Pro Leu Asn Leu Pro Met Pro Phe Gly Lys Gly Arg Ile Gln Arg Tyr
 545                 550                 555                 560
 Gln Asp Leu Gln Leu Asp Tyr Ser Leu Thr Asp Glu Phe Cys Arg Asn
                 565                 570                 575    
 His Phe Leu Val Gly Leu Leu Leu Arg Glu Val Gly Thr Ala Leu Gln
             580                 585                 590        
 Glu Phe Arg Glu Val Arg Leu Ile Ala Ile Ser Val Leu Lys Asn Leu
         595                 600                 605            
 Leu Ile Lys His Ser Phe Asp Asp Arg Tyr Ala Ser Arg Ser His Gln
     610                 615                 620                
 Ala Arg Ile Ala Thr Leu Tyr Leu Pro Leu Phe Gly Leu Leu Ile Glu
 625                 630                 635                 640
 Asn Val Gln Arg Ile Asn Val Arg Asp Val Ser Pro Phe Pro Val Asn
                 645                 650                 655    
 Ala Gly Met Thr Val Lys Asp Glu Ser Leu Ala Leu Pro Ala Val Asn
             660                 665                 670        
 Pro Leu Val Thr Pro Gln Lys Gly Ser Thr Leu Asp Asn Ser Leu His
         675                 680                 685            
 Lys Asp Leu Leu Gly Ala Ile Ser Gly Ile Ala Ser Pro Tyr Thr Thr
     690                 695                 700                
 Ser Thr Pro Asn Ile Asn Ser Val Arg Asn Ala Asp Ser Arg Gly Ser
 705                 710                 715                 720
 Leu Ile Ser Thr Asp Ser Gly Asn Ser Leu Pro Glu Arg Asn Ser Glu
                 725                 730                 735    
 Lys Ser Asn Ser Leu Asp Lys His Gln Gln Ser Ser Thr Leu Gly Asn
             740                 745                 750        
 Ser Val Val Arg Cys Asp Lys Leu Asp Gln Ser Glu Ile Lys Ser Leu
         755                 760                 765            
 Leu Met Cys Phe Leu Tyr Ile Leu Lys Ser Met Ser Asp Asp Ala Leu
     770                 775                 780                
 Phe Thr Tyr Trp Asn Lys Ala Ser Thr Ser Glu Leu Met Asp Phe Phe
 785                 790                 795                 800
 Thr Ile Ser Glu Val Cys Leu His Gln Phe Gln Tyr Met Gly Lys Arg
                 805                 810                 815    
 Tyr Ile Ala Arg Thr Gly Met Met His Ala Arg Leu Gln Gln Leu Gly
             820                 825                 830        
 Ser Leu Asp Asn Ser Leu Thr Phe Asn His Ser Tyr Gly His Ser Asp
         835                 840                 845            
 Ala Asp Val Leu His Gln Ser Leu Leu Glu Ala Asn Ile Ala Thr Glu
     850                 855                 860                
 Val Cys Leu Thr Ala Leu Asp Thr Leu Ser Leu Phe Thr Leu Ala Phe
 865                 870                 875                 880
 Lys Asn Gln Leu Leu Ala Asp His Gly His Asn Pro Leu Met Lys Lys
                 885                 890                 895    
 Val Phe Asp Val Tyr Leu Cys Phe Leu Gln Lys His Gln Ser Glu Thr
             900                 905                 910        
 Ala Leu Lys Asn Val Phe Thr Ala Leu Arg Ser Leu Ile Tyr Lys Phe
         915                 920                 925            
 Pro Ser Thr Phe Tyr Glu Gly Arg Ala Asp Met Cys Ala Ala Leu Cys
     930                 935                 940                
 Tyr Glu Ile Leu Lys Cys Cys Asn Ser Lys Leu Ser Ser Ile Arg Thr
 945                 950                 955                 960
 Glu Ala Ser Gln Leu Leu Tyr Phe Leu Met Arg Asn Asn Phe Asp Tyr
                 965                 970                 975    
 Thr Gly Lys Lys Ser Phe Val Arg Thr His Leu Gln Val Ile Ile Ser
             980                 985                 990        
 Val Ser Gln Leu Ile Ala Asp Val Val Gly Ile Gly Gly Thr Arg Phe
         995                1000                1005            
 Gln Gln Ser Leu Ser Ile Ile Asn Asn Cys Ala Asn Ser Asp Arg Leu
    1010                1015                1020                
 Ile Lys His Thr Ser Phe Ser Ser Asp Val Lys Asp Leu Thr Lys Arg
1025                1030                1035                1040
 Ile Arg Thr Val Leu Met Ala Thr Ala Gln Met Lys Glu His Glu Asn
                1045                1050                1055    
 Asp Pro Glu Met Leu Val Asp Leu Gln Tyr Ser Leu Ala Lys Ser Tyr
            1060                1065                1070        
 Ala Ser Thr Pro Glu Leu Arg Lys Thr Trp Leu Asp Ser Met Ala Arg
        1075                1080                1085            
 Ile His Val Lys Asn Gly Asp Leu Ser Glu Ala Ala Met Cys Tyr Val
    1090                1095                1100                
 His Val Thr Ala Leu Val Ala Glu Tyr Leu Thr Arg Lys Glu Ala Val
1105                1110                1115                1120
 Gln Trp Glu Pro Pro Leu Leu Pro His Ser His Ser Ala Cys Leu Arg
                1125                1130                1135    
 Arg Ser Arg Gly Gly Val Phe Arg Gln Gly Cys Thr Ala Phe Arg Val
            1140                1145                1150        
 Ile Thr Pro Asn Ile Asp Glu Glu Ala Ser Met Met Glu Asp Val Gly
        1155                1160                1165            
 Met Gln Asp Val His Phe Asn Glu Asp Val Leu Met Glu Leu Leu Glu
    1170                1175                1180                
 Gln Cys Ala Asp Gly Leu Trp Lys Ala Glu Arg Tyr Glu Leu Ile Ala
1185                1190                1195                1200
 Asp Ile Tyr Lys Leu Ile Ile Pro Ile Tyr Glu Lys Arg Arg Asp Phe
                1205                1210                1215    
 Glu Arg Leu Ala His Leu Tyr Asp Thr Leu His Arg Ala Tyr Ser Lys
            1220                1225                1230        
 Val Thr Glu Val Met His Ser Gly Arg Arg Leu Leu Gly Thr Tyr Phe
        1235                1240                1245            
 Arg Val Ala Phe Phe Gly Gln Ala Ala Gln Tyr Gln Phe Thr Asp Ser
    1250                1255                1260                
 Glu Thr Asp Val Glu Gly Phe Phe Glu Asp Glu Asp Gly Lys Glu Tyr
1265                1270                1275                1280
 Ile Tyr Lys Glu Pro Lys Leu Thr Pro Leu Ser Glu Ile Ser Gln Arg
                1285                1290                1295    
 Leu Leu Lys Leu Tyr Ser Asp Lys Phe Gly Ser Glu Asn Val Lys Met
            1300                1305                1310        
 Ile Gln Asp Ser Gly Lys Val Asn Pro Lys Asp Leu Asp Ser Lys Tyr
        1315                1320                1325            
 Ala Tyr Ile Gln Val Thr His Val Ile Pro Phe Phe Asp Glu Lys Glu
    1330                1335                1340                
 Leu Gln Glu Arg Lys Thr Glu Phe Glu Arg Ser His Asn Ile Arg Arg
1345                1350                1355                1360
 Phe Met Phe Glu Met Pro Phe Thr Gln Thr Gly Lys Arg Gln Gly Gly
                1365                1370                1375    
 Val Glu Glu Gln Cys Lys Arg Arg Thr Ile Leu Thr Ala Ile His Cys
            1380                1385                1390        
 Phe Pro Tyr Val Lys Lys Arg Ile Pro Val Met Tyr Gln His His Thr
        1395                1400                1405            
 Asp Leu Asn Pro Ile Glu Val Ala Ile Asp Glu Met Ser Lys Lys Val
    1410                1415                1420                
 Ala Glu Leu Arg Gln Leu Cys Ser Ser Ala Glu Val Asp Met Ile Lys
1425                1430                1435                1440
 Leu Gln Leu Lys Leu Gln Gly Ser Val Ser Val Gln Val Asn Ala Gly
                1445                1450                1455    
 Pro Leu Ala Tyr Ala Arg Ala Phe Leu Asp Asp Thr Asn Thr Lys Arg
            1460                1465                1470        
 Tyr Pro Asp Asn Lys Val Lys Leu Leu Lys Glu Val Phe Arg Gln Phe
        1475                1480                1485            
 Val Glu Ala Cys Gly Gln Ala Leu Ala Val Asn Glu Arg Leu Ile Lys
    1490                1495                1500                
 Glu Asp Gln Leu Glu Tyr Gln Glu Glu Met Lys Ala Asn Tyr Arg Glu
1505                1510                1515                1520
 Met Ala Lys Glu Leu Ser Glu Ile Met His Glu Gln Leu Gly
                1525                1530                



      <210> 2253
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 2253
 Met Arg Met Glu Ala Gly Glu Ala Ala Pro Pro Ala Gly Ala Gly Gly
   1               5                  10                  15    
 Arg Ala Ala Gly Gly Trp Gly Lys Trp Val Arg Leu Asn Val Gly Gly
              20                  25                  30        
 Thr Val Phe Leu Thr Thr Arg Gln Thr Leu Cys Arg Glu Gln Lys Ser
          35                  40                  45            
 Phe Leu Ser Arg Leu Cys Gln Gly Glu Glu Leu Gln Ser Asp Arg Asp
      50                  55                  60                
 Glu Thr Gly Ala Tyr Leu Ile Asp Arg Asp Pro Thr Tyr Phe Gly Pro
  65                  70                  75                  80
 Ile Leu Asn Phe Leu Arg His Gly Lys Leu Val Leu Asp Lys Asp Met
                  85                  90                  95    
 Ala Glu Glu Gly Val Leu Glu Glu Ala Glu Phe Tyr Asn Ile Gly Pro
             100                 105                 110        
 Leu Ile Arg Ile Ile Lys Asp Arg Met Glu Glu Lys Asp Tyr Thr Val
         115                 120                 125            
 Thr Gln Val Pro Pro Lys His Val Tyr Arg Val Leu Gln Cys Gln Glu
     130                 135                 140                
 Glu Glu Leu Thr Gln Met Val Ser Thr Met Ser Asp Gly Trp Arg Phe
 145                 150                 155                 160
 Glu Gln Leu Val Asn Ile Gly Ser Ser Tyr Asn Tyr Gly Ser Glu Asp
                 165                 170                 175    
 Gln Ala Glu Phe Leu Cys Val Val Ser Lys Glu Leu His Ser Thr Pro
             180                 185                 190        
 Asn Gly Leu Ser Ser Glu Ser Ser Arg Lys Thr Lys Ser Thr Glu Glu
         195                 200                 205            
 Gln Leu Glu Glu Gln Gln Gln Gln Glu Glu Glu Val Glu Glu Val Glu
     210                 215                 220                
 Val Glu Gln Val Gln Val Glu Ala Asp Ala Gln Glu Lys Cys Cys Tyr
 225                 230                 235                 240
 Lys Pro Glu Ala Pro Gly Cys Glu Ala Pro Asp His Leu Gln Gly Leu
                 245                 250                 255    
 Gly Val Pro Ile
             260



      <210> 2254
      <211> 731
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(731)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2254
 Ser Gly Cys Val Glu Met Leu Tyr Ser His Ser Leu Glu Tyr Asn Pro
   1               5                  10                  15    
 Glu Trp Ile Ser Val Gln Ser Ala Val Ala Pro Ala Gln Leu Ala Leu
              20                  25                  30        
 Asn Ser Asp Gly Asp Leu Xaa Leu His Ser Gly Glu Arg Thr Arg Arg
          35                  40                  45            
 Asp Xaa Gln Leu Pro Glu Ala Gly Gly Pro Gly Leu Gln Glu Pro Leu
      50                  55                  60                
 Gln Leu Gly Glu Leu Asp Ile Thr Ser Asp Glu Phe Ile Leu Asp Glu
  65                  70                  75                  80
 Val Asp Gly Val Asp Leu Arg His Tyr Ser Lys Gln Val Glu Leu Glu
                  85                  90                  95    
 Leu Gln Gln Ile Glu Gln Lys Ser Ile Arg Asp Tyr Ile Gln Glu Ser
             100                 105                 110        
 Glu Asn Ile Ala Ser Leu His Asn Gln Ile Thr Ala Cys Asp Ala Val
         115                 120                 125            
 Leu Glu Arg Met Glu Gln Met Leu Gly Ala Phe Gln Ser Asp Leu Ser
     130                 135                 140                
 Ser Ile Ser Ser Glu Ile Arg Thr Leu Gln Glu Gln Ser Gly Ala Met
 145                 150                 155                 160
 Asn Ile Arg Leu Arg Asn Arg Gln Ala Val Arg Gly Lys Leu Gly Glu
                 165                 170                 175    
 Leu Val Asp Gly Leu Val Val Pro Ser Ala Leu Val Thr Ala Ile Leu
             180                 185                 190        
 Glu Ala Pro Val Thr Glu Pro Arg Phe Leu Glu Gln Leu Gln Glu Leu
         195                 200                 205            
 Asp Ala Lys Ala Ala Ala Val Arg Glu Gln Glu Ala Arg Gly Thr Ala
     210                 215                 220                
 Ala Cys Ala Asp Val Arg Gly Val Leu Asp Arg Leu Arg Val Lys Ala
 225                 230                 235                 240
 Val Thr Lys Ile Arg Glu Phe Ile Leu Gln Lys Ile Tyr Ser Phe Arg
                 245                 250                 255    
 Lys Pro Met Thr Asn Tyr Gln Ile Pro Gln Thr Ala Leu Leu Lys Tyr
             260                 265                 270        
 Arg Phe Phe Tyr Gln Phe Leu Leu Gly Asn Glu Arg Ala Thr Ala Lys
         275                 280                 285            
 Glu Ile Arg Asp Glu Tyr Val Glu Thr Leu Ser Lys Ile Tyr Leu Ser
     290                 295                 300                
 Tyr Tyr Arg Ser Tyr Leu Gly Arg Leu Met Lys Val Gln Tyr Glu Glu
 305                 310                 315                 320
 Val Ala Glu Lys Asp Asp Leu Met Gly Val Glu Asp Thr Ala Lys Lys
                 325                 330                 335    
 Gly Phe Phe Ser Lys Pro Ser Leu Arg Ser Arg Asn Thr Ile Phe Thr
             340                 345                 350        
 Leu Gly Thr Arg Gly Ser Val Ile Ser Pro Thr Glu Leu Glu Ala Pro
         355                 360                 365            
 Ile Leu Val Pro His Thr Ala Gln Arg Gly Glu Gln Arg Tyr Pro Phe
     370                 375                 380                
 Glu Ala Leu Phe Arg Ser Gln His Tyr Ala Leu Leu Asp Asn Ser Cys
 385                 390                 395                 400
 Arg Glu Tyr Leu Phe Ile Cys Glu Phe Phe Val Val Ser Gly Pro Ala
                 405                 410                 415    
 Ala His Asp Leu Phe His Ala Val Met Gly Arg Thr Leu Ser Met Thr
             420                 425                 430        
 Leu Lys His Leu Asp Ser Tyr Leu Ala Asp Cys Tyr Asp Ala Ile Ala
         435                 440                 445            
 Val Phe Leu Cys Ile His Ile Val Leu Arg Phe Arg Asn Ile Ala Ala
     450                 455                 460                
 Lys Arg Asp Val Pro Ala Leu Asp Arg Tyr Trp Glu Gln Val Leu Ala
 465                 470                 475                 480
 Leu Leu Trp Pro Arg Phe Glu Leu Ile Leu Glu Met Asn Val Gln Ser
                 485                 490                 495    
 Val Arg Ser Thr Asp Pro Gln Arg Leu Gly Gly Leu Asp Thr Arg Pro
             500                 505                 510        
 His Tyr Ile Thr Arg Arg Tyr Ala Glu Phe Ser Ser Ala Leu Val Ser
         515                 520                 525            
 Ile Asn Gln Thr Ile Pro Asn Glu Arg Thr Met Gln Leu Leu Gly Gln
     530                 535                 540                
 Leu Gln Val Glu Val Glu Asn Phe Val Leu Arg Val Ala Ala Glu Phe
 545                 550                 555                 560
 Ser Ser Arg Lys Glu Gln Leu Val Phe Leu Ile Asn Asn Tyr Asp Met
                 565                 570                 575    
 Met Leu Gly Val Leu Met Glu Xaa Glu Arg Ala Ala Asp Asp Ser Lys
             580                 585                 590        
 Glu Val Glu Ser Phe Gln Gln Leu Leu Asn Ala Arg Thr Gln Glu Phe
         595                 600                 605            
 Ile Glu Glu Leu Leu Ser Pro Pro Phe Gly Gly Leu Val Ala Phe Val
     610                 615                 620                
 Lys Glu Ala Glu Ala Leu Ile Glu Arg Gly Gln Ala Glu Arg Leu Arg
 625                 630                 635                 640
 Gly Glu Glu Ala Arg Val Thr Gln Leu Ile Arg Gly Phe Gly Ser Ser
                 645                 650                 655    
 Trp Lys Ser Ser Val Glu Ser Leu Ser Gln Asp Val Met Arg Ser Phe
             660                 665                 670        
 Thr Asn Phe Arg Asn Gly Thr Ser Ile Ile Gln Gly Ala Leu Thr Gln
         675                 680                 685            
 Leu Ile Gln Leu Tyr His Arg Phe His Arg Val Leu Ser Gln Pro Gln
     690                 695                 700                
 Leu Arg Ala Leu Pro Ala Arg Ala Glu Leu Ile Asn Ile His His Leu
 705                 710                 715                 720
 Met Val Glu Leu Lys Lys His Lys Pro Asn Phe
                 725                 730    



      <210> 2255
      <211> 247
      <212> PRT
      <213> Homo sapiens


      <400> 2255
 Ala Ser Ile Thr Val Ser Ser Gly Arg Ile Pro Thr Ser Leu Ser Val
   1               5                  10                  15    
 Gly Pro Pro Gly Ala Pro Leu His Arg Pro Gln Lys Pro Arg Glu Gly
              20                  25                  30        
 Ala Trp Asp Met Glu Asp Val Ala Pro Thr Gly Val Arg Gln Ala Phe
          35                  40                  45            
 Ser Glu Leu Pro Phe Pro Ser His Val Leu Pro Glu Pro Gly Phe Pro
      50                  55                  60                
 Asp Thr Asp Pro Ser Gln Val Tyr Ser Pro Gly Leu Pro Pro Ala Pro
  65                  70                  75                  80
 Ala Gln Pro Ser Ser Ile Pro Pro Cys Ala Leu Val Ser Gln Pro Thr
                  85                  90                  95    
 Val Gln Phe Ile Leu Gln Gly Ser Leu Pro Leu Val Gly Cys Gly Ala
             100                 105                 110        
 Ala Gln Thr Leu Ala Pro Val Pro Ala Ala Leu Thr Pro Ala Ser Glu
         115                 120                 125            
 Pro Ala Ser Gln Ala Thr Ala Ala Ser Asn Ser Glu Glu Lys Thr Pro
     130                 135                 140                
 Ala Pro Arg Leu Ala Ala Glu Lys Thr Lys Lys Glu Glu Tyr Met Lys
 145                 150                 155                 160
 Lys Leu His Met Gln Glu Arg Ala Val Glu Glu Val Lys Leu Ala Ile
                 165                 170                 175    
 Lys Pro Phe Tyr Gln Lys Arg Glu Val Thr Lys Glu Glu Tyr Lys Asp
             180                 185                 190        
 Ile Leu Arg Lys Ala Val Gln Lys Ile Cys His Ser Lys Ser Gly Glu
         195                 200                 205            
 Ile Asn Pro Val Lys Val Ala Asn Leu Val Lys Ala Tyr Val Asp Lys
     210                 215                 220                
 Tyr Arg His Met Arg Arg His Lys Lys Pro Glu Ala Gly Glu Glu Pro
 225                 230                 235                 240
 Pro Thr Gln Gly Ala Glu Gly
                 245        



      <210> 2256
      <211> 247
      <212> PRT
      <213> Homo sapiens


      <400> 2256
 Ala Ser Ile Thr Val Ser Ser Gly Arg Ile Pro Thr Ser Leu Ser Val
   1               5                  10                  15    
 Gly Pro Pro Gly Ala Pro Leu His Arg Pro Gln Lys Pro Arg Glu Gly
              20                  25                  30        
 Ala Trp Asp Met Glu Asp Val Ala Pro Thr Gly Val Arg Gln Ala Phe
          35                  40                  45            
 Ser Glu Leu Pro Phe Pro Ser His Val Leu Pro Glu Pro Gly Phe Pro
      50                  55                  60                
 Asp Thr Asp Pro Ser Gln Val Tyr Ser Pro Gly Leu Pro Pro Ala Pro
  65                  70                  75                  80
 Ala Gln Pro Ser Ser Ile Pro Pro Cys Ala Leu Val Ser Gln Pro Thr
                  85                  90                  95    
 Val Gln Phe Ile Leu Gln Gly Ser Leu Pro Leu Val Gly Cys Gly Ala
             100                 105                 110        
 Ala Gln Thr Leu Ala Pro Val Pro Ala Ala Leu Thr Pro Ala Ser Glu
         115                 120                 125            
 Pro Ala Ser Gln Ala Thr Ala Ala Ser Asn Ser Glu Glu Lys Thr Pro
     130                 135                 140                
 Ala Pro Arg Leu Ala Ala Glu Lys Thr Lys Lys Glu Glu Tyr Met Lys
 145                 150                 155                 160
 Lys Leu His Met Gln Glu Arg Ala Val Glu Glu Val Lys Leu Ala Ile
                 165                 170                 175    
 Lys Pro Phe Tyr Gln Lys Arg Glu Val Thr Lys Glu Glu Tyr Lys Asp
             180                 185                 190        
 Ile Leu Arg Lys Ala Val Gln Lys Ile Cys His Ser Lys Ser Gly Glu
         195                 200                 205            
 Ile Asn Pro Val Lys Val Ala Asn Leu Val Lys Ala Tyr Val Asp Lys
     210                 215                 220                
 Tyr Arg His Met Arg Arg His Lys Lys Pro Glu Ala Gly Glu Glu Pro
 225                 230                 235                 240
 Pro Thr Gln Gly Ala Glu Gly
                 245        



      <210> 2257
      <211> 126
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(126)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2257
 Phe Phe Phe Gly Asn Gly Val Ser Pro Cys Arg Gln Ala Gly Val Xaa
   1               5                  10                  15    
 Trp His Asp Leu Asp Ser Leu Gln Asn Leu Pro Pro Gly Phe Lys Arg
              20                  25                  30        
 Phe Ser Tyr Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg His Val Leu
          35                  40                  45            
 Pro Arg Gln Ala Asn Phe Cys Ile Phe Met Xaa Arg Arg Gly Phe Thr
      50                  55                  60                
 Met Leu Ala Arg Met Val Ser Ile Ser Xaa Pro Arg Asp Leu Pro Ala
  65                  70                  75                  80
 Leu Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Ser His His Ala Pro
                  85                  90                  95    
 Pro Gln Met Asp Phe Thr Phe Ala Leu Leu Cys Phe Ala Leu Lys Gly
             100                 105                 110        
 Cys Leu Pro Arg Gln Lys Glu Gly Gly Thr Leu Asn Leu Ile
         115                 120                 125    



      <210> 2258
      <211> 383
      <212> PRT
      <213> Homo sapiens


      <400> 2258
 Thr Arg Met Ser Arg His Glu Gly Val Ser Cys Asp Ala Cys Leu Lys
   1               5                  10                  15    
 Gly Asn Phe Arg Gly Arg Arg Tyr Lys Cys Leu Ile Cys Tyr Asp Tyr
              20                  25                  30        
 Asp Leu Cys Ala Ser Cys Tyr Glu Ser Gly Ala Thr Thr Thr Arg His
          35                  40                  45            
 Thr Thr Asp His Pro Met Gln Cys Ile Leu Thr Arg Val Asp Phe Asp
      50                  55                  60                
 Leu Tyr Tyr Gly Gly Glu Ala Phe Ser Val Glu Gln Pro Gln Ser Phe
  65                  70                  75                  80
 Thr Cys Pro Tyr Cys Gly Lys Met Gly Tyr Thr Glu Thr Ser Leu Gln
                  85                  90                  95    
 Glu His Val Thr Ser Glu His Ala Glu Thr Ser Thr Glu Val Ile Cys
             100                 105                 110        
 Pro Ile Cys Ala Ala Leu Pro Gly Gly Asp Pro Asn His Val Thr Asp
         115                 120                 125            
 Asp Phe Ala Ala His Leu Thr Leu Glu His Arg Ala Pro Arg Asp Leu
     130                 135                 140                
 Asp Glu Ser Ser Gly Val Arg His Val Arg Arg Met Phe His Pro Gly
 145                 150                 155                 160
 Arg Gly Leu Gly Gly Pro Arg Ala Arg Arg Ser Asn Met His Phe Thr
                 165                 170                 175    
 Ser Ser Ser Thr Gly Gly Leu Ser Ser Ser Gln Ser Ser Tyr Ser Pro
             180                 185                 190        
 Ser Asn Arg Glu Ala Met Asp Pro Ile Ala Glu Leu Leu Ser Gln Leu
         195                 200                 205            
 Ser Gly Val Arg Arg Ser Ala Gly Gly Gln Leu Asn Ser Ser Gly Pro
     210                 215                 220                
 Ser Ala Ser Gln Leu Gln Gln Leu Gln Met Gln Leu Gln Leu Glu Arg
 225                 230                 235                 240
 Gln His Ala Gln Ala Ala Arg Gln Gln Leu Glu Thr Ala Arg Asn Ala
                 245                 250                 255    
 Thr Arg Arg Thr Asn Thr Ser Ser Val Thr Thr Thr Ile Thr Gln Ser
             260                 265                 270        
 Thr Ala Thr Thr Asn Ile Ala Asn Thr Glu Ser Ser Gln Gln Thr Leu
         275                 280                 285            
 Gln Asn Ser Gln Phe Leu Leu Thr Arg Leu Asn Asp Pro Lys Met Ser
     290                 295                 300                
 Glu Thr Glu Arg Gln Ser Met Glu Ser Glu Arg Ala Asp Arg Ser Leu
 305                 310                 315                 320
 Phe Val Gln Glu Leu Leu Leu Ser Thr Leu Val Arg Glu Glu Ser Ser
                 325                 330                 335    
 Ser Ser Asp Glu Asp Asp Arg Gly Glu Met Ala Asp Phe Gly Ala Met
             340                 345                 350        
 Gly Cys Val Asp Ile Met Pro Leu Asp Val Ala Leu Glu Asn Leu Asn
         355                 360                 365            
 Leu Lys Glu Ser Asn Lys Gly Asn Glu Pro Pro Pro Pro Pro Leu
     370                 375                 380            



      <210> 2259
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 2259
 Ser Trp Pro Gly Gln Ala Glu Pro Ser Glu Arg Glu Phe Val Val Arg
   1               5                  10                  15    
 Glu Ala Ala Glu Thr Arg Gly Ser Glu Val Phe Glu Ile Met Asn Pro
              20                  25                  30        
 Val Tyr Ser Pro Gly Ser Ser Gly Val Pro Tyr Ala Asn Ala Lys Gly
          35                  40                  45            
 Ile Gly Tyr Pro Ala Gly Phe Pro Met Gly Tyr Ala Ala Ala Ala Pro
      50                  55                  60                
 Ala Tyr Ser Pro Asn Met Tyr Pro Gly Ala Asn Pro Thr Phe Gln Thr
  65                  70                  75                  80
 Gly Tyr Thr Pro Gly Thr Pro Tyr Lys Val Ser Cys Ser Pro Thr Ser
                  85                  90                  95    
 Gly Ala Val Pro Pro Tyr Ser Ser Ser Pro Asn Pro Tyr Gln Thr Ala
             100                 105                 110        
 Val Tyr Pro Val Arg Ser Ala Tyr Pro Gln Gln Ser Pro Tyr Ala Gln
         115                 120                 125            
 Gln Gly Thr Tyr Tyr Thr Gln Pro Leu Tyr Ala Ala Pro Pro His Val
     130                 135                 140                
 Ile His His Thr Thr Val Val Gln Pro Asn Gly Met Pro Ala Thr Val
 145                 150                 155                 160
 Tyr Pro Ala Pro Ile Pro Pro Pro Arg Gly Asn Gly Val Thr Met Gly
                 165                 170                 175    
 Met Val Ala Gly Thr Thr Met Ala Met Ser Ala Gly Thr Leu Leu Thr
             180                 185                 190        
 Ala His Ser Pro Thr Pro Val Ala Pro His Pro Val Thr Val Pro Thr
         195                 200                 205            
 Tyr Arg Ala Gln Gly Thr Pro Thr Tyr Ser Tyr Val Pro Pro Gln Trp
     210                 215                 220                





      <210> 2260
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 2260
 Met Val Leu Ser Val Pro Val Ile Ala Leu Gly Ala Thr Leu Gly Thr
   1               5                  10                  15    
 Ala Thr Ser Ile Leu Ala Leu Cys Gly Val Thr Cys Leu Cys Arg His
              20                  25                  30        
 Met His Pro Lys Lys Gly Leu Leu Pro Arg Asp Gln Asp Pro Asp Leu
          35                  40                  45            
 Glu Lys Ala Lys Pro Ser Leu Leu Gly Ser Ala Gln Arg Phe Asn Val
      50                  55                  60                
 Lys Lys Ser Thr Glu Pro Val Gln Pro Arg Ala Leu Leu Lys Phe Pro
  65                  70                  75                  80
 Asp Ile Tyr Gly Pro Arg Pro Ala Val Thr Ala Pro Glu Val Ile Asn
                  85                  90                  95    
 Tyr Ala Asp Tyr Ser Leu Arg Ser Thr Glu Glu Pro Thr Ala Pro Ala
             100                 105                 110        
 Ser Pro Gln Pro Pro Asn Asp Ser Arg Leu Lys Arg Gln Val Thr Glu
         115                 120                 125            
 Glu Leu Phe Ile Leu Pro Gln Asn Gly Val Val Glu Asp Val Cys Val
     130                 135                 140                
 Met Glu Thr Trp Asn Pro Gln Lys Ala Gly Ser Trp Asn Gln Ala Pro
 145                 150                 155                 160
 Lys Leu His Tyr Cys Leu Asp Tyr Asp Cys His Lys Ala Glu Cys Leu
                 165                 170                 175    





      <210> 2261
      <211> 1050
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1050)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2261
 His Pro Ser Pro Gly Phe Asp Arg Val Arg Ala Ala Met Asp Pro Asn
   1               5                  10                  15    
 Thr Ile Ile Glu Ala Leu Arg Gly Thr Met Asp Pro Ala Leu Arg Glu
              20                  25                  30        
 Ala Ala Glu Arg Gln Leu Asn Glu Ala His Lys Ser Leu Asn Phe Val
          35                  40                  45            
 Ser Thr Leu Leu Gln Ile Thr Met Ser Glu Gln Leu Asp Leu Pro Val
      50                  55                  60                
 Arg Gln Ala Gly Val Ile Tyr Leu Lys Asn Met Ile Thr Gln Tyr Trp
  65                  70                  75                  80
 Pro Asp Arg Glu Thr Ala Pro Gly Asp Ile Ser Pro Tyr Thr Ile Pro
                  85                  90                  95    
 Glu Glu Asp Arg His Cys Ile Arg Glu Asn Ile Val Glu Ala Ile Ile
             100                 105                 110        
 His Ser Pro Glu Leu Ile Arg Val Gln Leu Thr Thr Cys Ile His His
         115                 120                 125            
 Ile Ile Lys His Asp Tyr Pro Ser Arg Trp Thr Ala Ile Val Asp Lys
     130                 135                 140                
 Ile Gly Phe Tyr Leu Gln Ser Asp Asn Ser Ala Cys Trp Leu Gly Ile
 145                 150                 155                 160
 Leu Leu Cys Leu Tyr Gln Leu Val Lys Asn Tyr Glu Tyr Lys Lys Pro
                 165                 170                 175    
 Glu Glu Arg Ser Pro Leu Val Ala Ala Met Gln His Phe Leu Pro Val
             180                 185                 190        
 Leu Lys Asp Arg Phe Ile Gln Leu Leu Ser Asp Gln Ser Asp Gln Ser
         195                 200                 205            
 Val Leu Ile Gln Lys Gln Ile Phe Lys Ile Phe Tyr Ala Leu Val Gln
     210                 215                 220                
 Tyr Thr Leu Pro Leu Glu Leu Ile Asn Gln Gln Asn Leu Thr Glu Trp
 225                 230                 235                 240
 Ile Glu Ile Leu Lys Thr Val Val Asn Arg Asp Val Pro Asn Glu Thr
                 245                 250                 255    
 Leu Gln Val Glu Glu Asp Asp Arg Pro Glu Leu Pro Trp Trp Lys Cys
             260                 265                 270        
 Lys Lys Trp Ala Leu His Ile Leu Ala Arg Leu Phe Glu Arg Tyr Gly
         275                 280                 285            
 Ser Pro Gly Asn Val Ser Lys Glu Tyr Asn Glu Phe Ala Glu Val Phe
     290                 295                 300                
 Leu Lys Ala Phe Ala Val Gly Val Gln Gln Val Leu Leu Lys Val Leu
 305                 310                 315                 320
 Tyr Gln Tyr Lys Glu Lys Gln Tyr Met Ala Pro Arg Val Leu Gln Gln
                 325                 330                 335    
 Thr Leu Asn Tyr Ile Asn Gln Gly Val Ser His Ala Leu Thr Trp Lys
             340                 345                 350        
 Asn Leu Lys Pro His Ile Gln Gly Ile Ile Gln Asp Val Ile Phe Pro
         355                 360                 365            
 Leu Met Cys Tyr Thr Asp Ala Asp Glu Glu Leu Trp Gln Glu Asp Pro
     370                 375                 380                
 Tyr Glu Tyr Ile Arg Met Lys Phe Asp Val Phe Glu Asp Phe Ile Ser
 385                 390                 395                 400
 Pro Thr Thr Ala Ala Gln Thr Leu Leu Phe Thr Ala Cys Ser Lys Arg
                 405                 410                 415    
 Lys Glu Val Leu Gln Lys Thr Met Gly Phe Cys Tyr Gln Ile Leu Thr
             420                 425                 430        
 Glu Pro Asn Ala Asp Pro Arg Lys Lys Asp Gly Ala Leu His Met Ile
         435                 440                 445            
 Gly Ser Leu Ala Glu Ile Leu Leu Lys Lys Lys Ile Tyr Lys Asp Gln
     450                 455                 460                
 Met Glu Tyr Met Leu Pro Glu Ser Met Tyr Ser Pro Leu Phe Ser Ser
 465                 470                 475                 480
 Glu Leu Gly Tyr Met Arg Ala Arg Ala Cys Trp Val Leu His Tyr Phe
                 485                 490                 495    
 Cys Glu Val Lys Phe Lys Ser Asp Gln Asn Leu Gln Thr Ala Leu Glu
             500                 505                 510        
 Leu Thr Arg Arg Cys Leu Ile Asp Asp Arg Glu Met Pro Val Lys Val
         515                 520                 525            
 Glu Ala Ala Ile Ala Leu Gln Val Leu Ile Ser Asn Gln Glu Lys Ala
     530                 535                 540                
 Lys Glu Tyr Ile Thr Pro Phe Ile Arg Pro Val Met Gln Ala Leu Leu
 545                 550                 555                 560
 His Ile Ile Arg Glu Thr Glu Asn Asp Asp Leu Thr Asn Val Ile Gln
                 565                 570                 575    
 Lys Met Ile Cys Glu Tyr Ser Glu Glu Val Thr Pro Ile Ala Val Glu
             580                 585                 590        
 Met Thr Gln His Leu Ala Met Thr Phe Asn Gln Val Ile Gln Thr Gly
         595                 600                 605            
 Pro Asp Glu Glu Gly Ser Asp Asp Lys Ala Val Thr Ala Met Gly Ile
     610                 615                 620                
 Leu Asn Thr Ile Asp Thr Leu Leu Ser Val Val Glu Asp His Lys Glu
 625                 630                 635                 640
 Ile Thr Gln Gln Leu Glu Gly Ile Cys Leu Gln Val Ile Gly Thr Val
                 645                 650                 655    
 Leu Gln Gln His Val Leu Glu Phe Tyr Glu Glu Ile Phe Ser Leu Ala
             660                 665                 670        
 His Ser Leu Thr Cys Gln Gln Val Ser Pro Gln Met Trp Gln Leu Leu
         675                 680                 685            
 Pro Leu Val Phe Glu Val Phe Gln Gln Asp Gly Phe Asp Tyr Phe Thr
     690                 695                 700                
 Asp Met Met Pro Leu Leu His Asn Tyr Val Thr Val Asp Thr Asp Thr
 705                 710                 715                 720
 Leu Leu Ser Asp Thr Lys Tyr Leu Glu Met Ile Tyr Ser Met Cys Lys
                 725                 730                 735    
 Lys Val Leu Thr Gly Val Ala Gly Glu Asp Ala Glu Cys His Ala Ala
             740                 745                 750        
 Lys Leu Leu Glu Val Ile Ile Leu Gln Cys Lys Gly Arg Gly Ile Asp
         755                 760                 765            
 Gln Cys Ile Pro Leu Phe Val Glu Ala Ala Leu Glu Arg Leu Thr Arg
     770                 775                 780                
 Glu Val Lys Thr Ser Glu Leu Xaa Thr Met Gly Leu Gln Val Ala Ile
 785                 790                 795                 800
 Ala Ala Leu His Tyr Asn Ala Tyr Leu Leu Leu Asn Thr Leu Glu Asn
                 805                 810                 815    
 Leu His Phe Pro Asn Asn Val Glu Pro Val Thr Asn His Phe Ile Gln
             820                 825                 830        
 Trp Leu Asn Asp Val Asp Cys Phe Leu Gly Leu His Asp Arg Arg Met
         835                 840                 845            
 Cys Val Leu Ser Leu Cys Ala Leu Ile Asp Met Glu Gln Ile Pro Gln
     850                 855                 860                
 Gly Leu Asn Gln Val Ser Gly Gln Ile Leu Pro Ala Phe Ile Leu Leu
 865                 870                 875                 880
 Phe Asn Gly Leu Lys Arg Ala Tyr Ala Cys His Ala Glu His Glu Asn
                 885                 890                 895    
 Asp Ser Asp Asp Asp Asp Glu Ala Glu Asp Asp Asp Glu Thr Glu Glu
             900                 905                 910        
 Leu Gly Ser Asp Glu Asp Asp Ile Asp Glu Asp Gly Gln Glu Tyr Leu
         915                 920                 925            
 Glu Ile Leu Ala Lys Gln Ala Gly Glu Asp Gly Asp Asp Glu Asp Trp
     930                 935                 940                
 Glu Glu Asp Asp Ala Glu Glu Thr Ala Leu Glu Gly Tyr Ser Thr Ile
 945                 950                 955                 960
 Ile Asp Asp Glu Asp Asn Pro Val Asp Glu Tyr Gln Ile Phe Lys Ala
                 965                 970                 975    
 Ile Phe Gln Thr Ile Gln Asn Arg Asn Pro Val Trp Tyr Gln Ala Leu
             980                 985                 990        
 Thr His Gly Leu Asn Glu Glu Gln Arg Lys Gln Leu Gln Asp Ile Ala
         995                1000                1005            
 Thr Leu Ala Asp Gln Arg Arg Ala Ala His Glu Ser Lys Met Ile Glu
    1010                1015                1020                
 Lys His Gly Gly Tyr Lys Phe Ser Ala Pro Val Val Pro Ser Ser Phe
1025                1030                1035                1040
 Asn Phe Gly Gly Pro Ala Pro Gly Met Asn
                1045                1050



      <210> 2262
      <211> 738
      <212> PRT
      <213> Homo sapiens


      <400> 2262
 Ala Glu Gly Cys Ala Glu Arg Arg Gly Thr Glu Pro Val Val Glu Leu
   1               5                  10                  15    
 Ser Met Ser Trp Glu Ser Gly Ala Gly Pro Gly Leu Gly Ser Gln Gly
              20                  25                  30        
 Met Asp Leu Val Trp Ser Ala Trp Tyr Gly Lys Cys Val Lys Gly Lys
          35                  40                  45            
 Gly Ser Leu Pro Leu Ser Ala His Gly Ile Val Val Ala Trp Leu Ser
      50                  55                  60                
 Arg Ala Glu Trp Asp Gln Val Thr Val Tyr Leu Phe Cys Asp Asp His
  65                  70                  75                  80
 Lys Leu Gln Arg Tyr Ala Leu Asn Arg Ile Thr Val Trp Arg Ser Arg
                  85                  90                  95    
 Ser Gly Asn Glu Leu Pro Leu Ala Val Ala Ser Thr Ala Asp Leu Ile
             100                 105                 110        
 Arg Cys Lys Leu Leu Asp Val Thr Gly Gly Leu Gly Thr Asp Glu Leu
         115                 120                 125            
 Arg Leu Leu Tyr Gly Met Ala Leu Val Arg Phe Val Asn Leu Ile Ser
     130                 135                 140                
 Glu Arg Lys Thr Lys Phe Ala Lys Val Pro Leu Lys Cys Leu Ala Gln
 145                 150                 155                 160
 Glu Val Asn Ile Pro Asp Trp Ile Val Asp Leu Arg His Glu Leu Thr
                 165                 170                 175    
 His Lys Lys Met Pro His Ile Asn Asp Cys Arg Arg Gly Cys Tyr Phe
             180                 185                 190        
 Val Leu Asp Trp Leu Gln Lys Thr Tyr Trp Cys Arg Gln Leu Glu Asn
         195                 200                 205            
 Ser Leu Arg Glu Thr Trp Glu Leu Glu Glu Phe Arg Glu Gly Ile Glu
     210                 215                 220                
 Glu Glu Asp Gln Glu Glu Asp Lys Asn Ile Val Val Asp Asp Ile Thr
 225                 230                 235                 240
 Glu Gln Lys Pro Glu Pro Gln Asp Asp Gly Lys Ser Thr Glu Ser Asp
                 245                 250                 255    
 Val Lys Ala Asp Gly Asp Ser Lys Gly Ser Glu Glu Val Asp Ser His
             260                 265                 270        
 Cys Lys Lys Ala Leu Ser His Lys Glu Leu Tyr Glu Arg Ala Arg Glu
         275                 280                 285            
 Leu Leu Val Ser Tyr Glu Glu Glu Gln Phe Thr Val Leu Glu Lys Phe
     290                 295                 300                
 Arg Tyr Leu Pro Lys Ala Ile Lys Ala Trp Asn Asn Pro Ser Pro Arg
 305                 310                 315                 320
 Val Glu Cys Val Leu Ala Glu Leu Lys Gly Val Thr Cys Glu Asn Arg
                 325                 330                 335    
 Glu Ala Val Leu Asp Ala Phe Leu Asp Asp Gly Phe Leu Val Pro Thr
             340                 345                 350        
 Phe Glu Gln Leu Ala Ala Leu Gln Ile Glu Tyr Glu Glu Asn Val Asp
         355                 360                 365            
 Leu Asn Asp Val Leu Val Pro Lys Pro Phe Ser Gln Phe Trp Gln Pro
     370                 375                 380                
 Leu Leu Arg Gly Leu His Ser Gln Asn Phe Thr Gln Ala Leu Leu Glu
 385                 390                 395                 400
 Arg Met Leu Ser Glu Leu Pro Ala Leu Gly Ile Ser Gly Ile Arg Pro
                 405                 410                 415    
 Thr Tyr Ile Leu Arg Trp Thr Val Glu Leu Ile Val Ala Asn Thr Lys
             420                 425                 430        
 Thr Gly Arg Asn Ala Arg Arg Phe Ser Ala Gly Gln Trp Glu Ala Arg
         435                 440                 445            
 Arg Gly Trp Arg Leu Phe Asn Cys Ser Ala Ser Leu Asp Trp Pro Arg
     450                 455                 460                
 Met Val Glu Ser Cys Leu Gly Ser Pro Cys Trp Ala Ser Pro Gln Leu
 465                 470                 475                 480
 Leu Arg Ile Ile Phe Lys Ala Met Gly Gln Gly Leu Gln Asp Glu Glu
                 485                 490                 495    
 Gln Glu Lys Leu Leu Arg Ile Cys Ser Ile Tyr Thr Gln Ser Gly Glu
             500                 505                 510        
 Asn Ser Leu Val Gln Glu Gly Ser Glu Ala Ser Pro Ile Gly Lys Ser
         515                 520                 525            
 Pro Tyr Thr Leu Asp Ser Leu Tyr Trp Ser Val Lys Pro Ala Ser Ser
     530                 535                 540                
 Ser Phe Gly Ser Glu Ala Lys Ala Gln Gln Gln Glu Glu Gln Gly Ser
 545                 550                 555                 560
 Val Asn Asp Val Lys Glu Glu Glu Lys Glu Glu Lys Glu Val Leu Pro
                 565                 570                 575    
 Asp Gln Val Glu Glu Glu Glu Glu Asn Asp Asp Gln Glu Glu Glu Glu
             580                 585                 590        
 Glu Asp Glu Asp Asp Glu Asp Asp Glu Glu Glu Asp Arg Met Glu Val
         595                 600                 605            
 Gly Pro Phe Ser Thr Gly Gln Glu Ser Pro Thr Ala Glu Asn Ala Arg
     610                 615                 620                
 Leu Leu Ala Gln Lys Arg Gly Ala Leu Gln Gly Ser Ala Trp Gln Val
 625                 630                 635                 640
 Ser Ser Glu Asp Val Arg Trp Asp Thr Phe Pro Leu Gly Arg Met Pro
                 645                 650                 655    
 Arg Ser Arg Pro Arg Thr Pro Ala Glu Leu Met Leu Glu Asn Tyr Asp
             660                 665                 670        
 Thr His Val Ile Phe Trp Thr Lys Pro Val Leu Glu Gln Arg Leu Glu
         675                 680                 685            
 Pro Ser Thr Cys Lys Thr Asp Thr Leu Gly Leu Ser Cys Gly Val Gly
     690                 695                 700                
 Ser Gly Asn Cys Ser Asn Ser Ser Ser Ser Asn Phe Arg Gly Ala Phe
 705                 710                 715                 720
 Leu Leu Glu Ala Arg Gly Ser Leu His Gly Leu Lys Thr Gly Leu Gln
                 725                 730                 735    
 Leu Phe
        



      <210> 2263
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 2263
 Leu Gly Asn Thr Val Leu His Tyr Cys Ser Met Tyr Ser Lys Pro Glu
   1               5                  10                  15    
 Cys Leu Lys Leu Leu Leu Arg Ser Lys Pro Thr Val Asp Ile Val Asn
              20                  25                  30        
 Gln Ala Gly Glu Thr Ala Leu Asp Ile Ala Lys Arg Leu Lys Ala Thr
          35                  40                  45            
 Gln Cys Glu Asp Leu Leu Ser Gln Ala Lys Ser Gly Lys Phe Asn Pro
      50                  55                  60                
 His Val His Val Glu Tyr Glu Trp Asn Leu Arg Gln Glu Glu Ile Asp
  65                  70                  75                  80
 Glu Ser Asp Asp Asp Leu Asp Asp Lys Pro Ser Pro Val Lys Lys Glu
                  85                  90                  95    
 Arg Ser Pro Arg Pro Gln Ser Phe Cys His Ser Ser Ser Ile Ser Pro
             100                 105                 110        
 Gln Asp Lys Leu Ala Leu Pro Gly Phe Ser Thr Pro Arg Asp Lys Gln
         115                 120                 125            
 Arg Leu Ser Tyr Gly Ala Phe Thr Asn Gln Ile Phe Val Ser Thr Ser
     130                 135                 140                
 Thr Asp Ser Pro Thr Ser Pro Thr Thr Glu Ala Pro Pro Leu Pro Pro
 145                 150                 155                 160
 Arg Asn Ala Gly Lys Gly Pro Thr Gly Pro Pro Ile Thr Pro His Arg
                 165                 170                 175    





      <210> 2264
      <211> 140
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(140)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2264
 Ala Pro Gly Ala Ser Val Gly Arg Ala Gln Ala Ala Glu Gly Xaa Arg
   1               5                  10                  15    
 Gly Gly Pro Thr Gly Arg Pro Pro Ser Ala Leu Gly Val Ser Glu Ala
              20                  25                  30        
 Gly Arg Ala Gly Arg Ala Gly Glu Gly Arg Pro Val Pro Pro Ala Tyr
          35                  40                  45            
 Pro Leu Cys Lys Ser Ala Gln Thr Ser Gly Pro Pro Lys Ala Arg Leu
      50                  55                  60                
 Ser Pro Pro Leu Ala Ser Cys Gly Gly Arg Gly Pro Pro Gly Gly Ala
  65                  70                  75                  80
 Ala Cys Ala Thr Cys Ala Pro Pro Ala Gly Pro Ala Arg Ser Ser Arg
                  85                  90                  95    
 Cys Arg Arg Arg Ser Pro Pro Glu Xaa Gly Pro Arg Xaa Pro Ser Arg
             100                 105                 110        
 Pro Ala Arg Pro Ser Pro Gly Ser Ala Ala Ser Arg Arg Gln Lys Leu
         115                 120                 125            
 Thr Pro Cys Arg Cys Gln Phe Arg Gly Leu Cys Ala
     130                 135                 140



      <210> 2265
      <211> 580
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(580)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2265
 Val Ser Ala Val Glu Phe Val Leu His Gly Lys Asp Phe Gln Val Asp
   1               5                  10                  15    
 Cys Lys Ala Ser Gly Ser Pro Val Pro Xaa Ile Ser Trp Ser Leu Leu
              20                  25                  30        
 Asp Gly Thr Met Ile Asn Asn Ala Met Gln Ala Asp Asp Ser Gly His
          35                  40                  45            
 Arg Thr Arg Arg Tyr Thr Leu Phe Asn Asn Gly Thr Leu Tyr Phe Asn
      50                  55                  60                
 Lys Val Gly Val Ala Glu Glu Gly Asp Tyr Thr Cys Tyr Ala Gln Asn
  65                  70                  75                  80
 Thr Leu Gly Lys Asp Glu Met Lys Val His Leu Thr Val Ile Thr Ala
                  85                  90                  95    
 Ala Pro Arg Ile Arg Gln Ser Asn Lys Thr Asn Lys Arg Ile Lys Ala
             100                 105                 110        
 Gly Asp Thr Ala Val Leu Asp Cys Glu Val Thr Gly Asp Pro Lys Pro
         115                 120                 125            
 Lys Ile Phe Trp Leu Leu Pro Ser Asn Asp Met Ile Ser Phe Ser Ile
     130                 135                 140                
 Asp Arg Tyr Thr Phe His Ala Asn Gly Ser Leu Thr Ile Asn Lys Val
 145                 150                 155                 160
 Lys Leu Leu Asp Ser Gly Glu Tyr Val Cys Val Ala Arg Asn Pro Ser
                 165                 170                 175    
 Gly Asp Asp Thr Lys Met Tyr Lys Leu Asp Val Val Ser Lys Pro Pro
             180                 185                 190        
 Leu Ile Asn Gly Leu Tyr Thr Asn Arg Thr Val Ile Lys Ala Thr Ala
         195                 200                 205            
 Val Arg His Ser Lys Lys His Phe Asp Cys Arg Ala Glu Gly Thr Pro
     210                 215                 220                
 Ser Pro Glu Val Met Trp Ile Met Pro Asp Asn Ile Phe Leu Thr Ala
 225                 230                 235                 240
 Pro Tyr Tyr Gly Ser Arg Ile Thr Val His Lys Asn Gly Thr Leu Glu
                 245                 250                 255    
 Ile Arg Asn Val Arg Leu Ser Asp Ser Ala Asp Phe Ile Cys Val Ala
             260                 265                 270        
 Arg Asn Glu Gly Gly Glu Ser Val Leu Val Val Gln Leu Glu Val Leu
         275                 280                 285            
 Glu Met Leu Arg Arg Pro Thr Phe Arg Asn Pro Phe Asn Glu Lys Ile
     290                 295                 300                
 Val Ala Gln Leu Gly Lys Ser Thr Ala Leu Asn Cys Ser Val Asp Gly
 305                 310                 315                 320
 Asn Pro Pro Pro Glu Ile Ile Trp Ile Leu Pro Asn Gly Thr Arg Phe
                 325                 330                 335    
 Ser Asn Gly Pro Gln Ser Tyr Gln Tyr Leu Ile Ala Ser Asn Gly Ser
             340                 345                 350        
 Phe Ile Ile Ser Lys Thr Thr Arg Glu Asp Ala Gly Lys Tyr Arg Cys
         355                 360                 365            
 Ala Ala Arg Asn Lys Val Gly Tyr Ile Glu Lys Leu Val Ile Leu Glu
     370                 375                 380                
 Ile Gly Gln Lys Pro Val Ile Leu Thr Tyr Ala Pro Gly Thr Val Lys
 385                 390                 395                 400
 Gly Ile Ser Gly Glu Ser Leu Ser Leu His Cys Val Ser Asp Gly Ile
                 405                 410                 415    
 Pro Lys Pro Asn Ile Lys Trp Thr Met Pro Ser Gly Tyr Val Val Asp
             420                 425                 430        
 Arg Pro Gln Ile Asn Gly Lys Tyr Ile Leu His Asp Asn Gly Thr Leu
         435                 440                 445            
 Val Ile Lys Glu Ala Thr Ala Tyr Asp Arg Gly Asn Tyr Ile Cys Lys
     450                 455                 460                
 Ala Gln Asn Ser Val Gly His Thr Leu Ile Thr Val Pro Val Met Ile
 465                 470                 475                 480
 Val Ala Tyr Pro Pro Arg Ile Thr Asn Arg Pro Pro Arg Ser Ile Val
                 485                 490                 495    
 Thr Arg Thr Gly Ala Ala Phe Gln Leu His Cys Val Ala Leu Gly Val
             500                 505                 510        
 Pro Lys Pro Glu Ile Thr Trp Glu Met Pro Asp His Ser Leu Leu Ser
         515                 520                 525            
 Thr Ala Ser Lys Glu Arg Thr His Gly Ser Glu Gln Leu His Leu Gln
     530                 535                 540                
 Gly Thr Leu Val Ile Gln Asn Pro Gln Thr Ser Asp Ser Gly Ile Tyr
 545                 550                 555                 560
 Lys Cys Thr Ala Lys Asn Pro Leu Gly Ser Asp Tyr Ala Ala Thr Tyr
                 565                 570                 575    
 Ile Gln Val Ile
             580



      <210> 2266
      <211> 753
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(753)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2266
 Arg Trp His Gln Ala Pro Gly Pro Val Arg Gln Arg Pro Pro Asp Asp
   1               5                  10                  15    
 Leu Gln Pro Gly Pro Gly Leu Trp Met Pro Gly Pro Ala Arg Met Thr
              20                  25                  30        
 Thr Glu Ser Ala Gly Gln Lys Ile Lys Glu Leu Leu Ser Gly Ile Gly
          35                  40                  45            
 Asn Ile Ser Glu Arg Val Ser Phe Leu Lys Lys Arg Gly Xaa Pro Ala
      50                  55                  60                
 Glu Gln Gly Thr Asp Lys Pro Gln Arg Gly His Glu Arg Glu Arg Ala
  65                  70                  75                  80
 Leu Arg Gln Ala Ala Arg Ala Pro Asp Pro Ser Pro Ala Pro Pro Ala
                  85                  90                  95    
 Pro Pro Gly Ala Ala Cys Arg His Arg Met Cys Ser Trp Pro Pro Ala
             100                 105                 110        
 Cys Xaa Arg Thr Ala Ala Ala Ser Ala Trp Thr Arg Gly Gly Pro Cys
         115                 120                 125            
 Ala Ser Arg Cys Ser Pro Ala Pro Val Leu Ser Thr Trp Thr Arg Pro
     130                 135                 140                
 Ala Pro Pro Ser Pro Thr Pro Ser Pro Trp Thr Ser Ser Ala Pro Val
 145                 150                 155                 160
 Leu Gly Gly Arg Xaa Arg Tyr Pro Trp Ala Leu Val Arg Thr Ala Gly
                 165                 170                 175    
 Ser Thr Cys Pro Xaa Pro Cys Pro Ala Pro Val Leu Gln Ser Gln Gly
             180                 185                 190        
 Gly Gly Gly Arg Gly Pro Cys Pro Leu Arg Leu Xaa Gly Pro Pro Phe
         195                 200                 205            
 Trp Met Ser Ala Pro Pro Thr Ser Cys Pro Ser Lys Arg Gly Leu Pro
     210                 215                 220                
 Ala Pro Glu Gln Ala His Ser Gly His Ala Ala Val Ser Ala Leu Pro
 225                 230                 235                 240
 Trp Pro Gly Pro Ala Thr His Thr Gly Pro Leu Pro Thr Arg Pro His
                 245                 250                 255    
 Pro Arg Pro Trp Gly His Phe Ser Gly Asn Leu Ser Gly Ala Trp Gln
             260                 265                 270        
 Pro Ala Ser Arg Thr Arg Leu Pro Ala Gly Arg Val Pro Ala Pro Ile
         275                 280                 285            
 Cys Gly Phe His Gln Gly Val Gly Gly Ala Gly Ser Glu Leu Pro Xaa
     290                 295                 300                
 Arg Thr Ala Thr Gln Ala Cys Pro Cys Ala Val Pro Pro Cys Ser Gly
 305                 310                 315                 320
 Ser Leu Leu Arg Met Leu Leu Trp Thr Ser Xaa Gly Pro Glu His Tyr
                 325                 330                 335    
 Leu Pro Ser Arg Asp Gly Pro Xaa Trp Arg Gln Arg Ser Pro His Arg
             340                 345                 350        
 Pro Arg Gly Val Pro Xaa Pro Thr Cys Ala Gln Gln Gly Pro Ser Arg
         355                 360                 365            
 Pro Trp Arg Phe Lys Trp Lys Ala Pro Ser Gly Arg His Leu Gln Gly
     370                 375                 380                
 Ala Pro Cys Arg Cys Arg Ala His Ala Asp Asp Gly Asp Arg Ala Gly
 385                 390                 395                 400
 Arg Pro Gly Leu Gln Arg Ser Xaa Ser Pro Cys Ala Val Pro Pro Pro
                 405                 410                 415    
 Asp Pro Arg Gln Pro Arg Asp Thr Ala Ala Gly Gly Ala Asp Pro Ala
             420                 425                 430        
 Arg Pro Ala Leu His Gly Gly Xaa Gly Gln Leu Leu Cys His Arg Pro
         435                 440                 445            
 Glu Ala Ala Thr Gly Val Pro Ala Ala Ala Pro Pro Gln Pro His Pro
     450                 455                 460                
 Ala Val Thr Arg Arg Ala Cys Pro Trp Ala Leu Ala Thr Leu Pro Ala
 465                 470                 475                 480
 Ser Val Thr Ala Pro Pro Gly Leu Met Gly Xaa Arg Glu Thr Glu Leu
                 485                 490                 495    
 Ala Trp Pro Glu Pro Ser Gly Lys Val Gly Pro Gly His Val Gly Ala
             500                 505                 510        
 Glu Arg Ser Xaa Lys Cys Leu Glu Ala Val Glu His Lys Ala Asp Ser
         515                 520                 525            
 Asp Trp Glu Gln Pro Arg Arg Ala Leu Asn Leu Ala Gly Arg Ser Phe
     530                 535                 540                
 Ala Ser Ser Ala Gly Val Ser Pro Ser Leu Thr Ala Ala Ala Ala Pro
 545                 550                 555                 560
 Ala Leu Gly Leu Pro His Cys Trp Ala Ala Phe Pro Pro Pro Gln Gln
                 565                 570                 575    
 Pro Leu Arg Pro Gly Gly Ser Ala Gly His Ser Gly Pro Gly Gly Pro
             580                 585                 590        
 Gly Asn Arg Ile Ser Gly Val Trp Thr Trp Gly Glu Phe Val Thr Val
         595                 600                 605            
 Ala Ala Thr Pro Pro Gly Ala Pro Ala Ala Pro Leu Gly Gly Thr Thr
     610                 615                 620                
 Arg Cys Pro Thr Val Pro Leu Ser His Cys Ser His Cys Pro Ala Ala
 625                 630                 635                 640
 His Ser Gly Thr Pro Arg Trp Arg Val Leu Pro Glu Thr Lys Ala Gln
                 645                 650                 655    
 Asn Ser Met Gln Gly Ala Pro Ala Ser Ala Arg Gly Leu Val Pro His
             660                 665                 670        
 Gln Gly Arg Ala Ser Gly Trp Pro Val Ala Gly Met Leu Asn Asn Xaa
         675                 680                 685            
 Val Pro Pro Ala Gly Ala Val Pro Ser Thr Val His Tyr Phe Gln Gly
     690                 695                 700                
 His Ser Gly Gly Ala Val Ala Gly Gly Gly Pro Xaa Ala Pro Ala Pro
 705                 710                 715                 720
 Ser Leu Leu Pro Gln Pro Gly His Gly Pro Pro Pro Gly Ala Gly Val
                 725                 730                 735    
 Phe Ile Trp Gly Gly Cys Ser Arg Arg Ser Arg Cys Arg His Cys Pro
             740                 745                 750        
 Arg
    



      <210> 2267
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 2267
 Lys Ser Arg Pro Gly Thr Val Ala His Ala Cys Asn Pro Ser Thr Leu
   1               5                  10                  15    
 Gly Ser Arg Gly Gly Arg Ile Ile Pro Ala Gln Glu Phe Lys Thr Ser
              20                  25                  30        
 Leu Gly Asn Thr Val Ser Glu Pro Cys Leu Tyr Leu Arg Lys Asn Asn
          35                  40                  45            





      <210> 2268
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 2268
 Lys Ser Arg Pro Gly Thr Val Ala His Ala Cys Asn Pro Ser Thr Leu
   1               5                  10                  15    
 Gly Ser Arg Gly Gly Arg Ile Ile Pro Ala Gln Glu Phe Lys Thr Ser
              20                  25                  30        
 Leu Gly Asn Thr Val Ser Glu Pro Cys Leu Tyr Leu Arg Lys Asn Asn
          35                  40                  45            





      <210> 2269
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 2269
 Pro Arg Val Arg Leu Asn Gly Cys Gly Arg Leu Ala Ala Leu Gly Arg
   1               5                  10                  15    
 Gly Leu Lys Ser Phe Leu Arg Gly Thr Ser Leu Cys Glu Glu Ile Met
              20                  25                  30        
 Ser Leu Ala Leu Arg Ser Glu Leu Val Val Asp Lys Thr Lys Arg Lys
          35                  40                  45            
 Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile Lys Asp Ala
      50                  55                  60                
 Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp Tyr His Glu
  65                  70                  75                  80
 Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys Lys Ala Asp
                  85                  90                  95    
 Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr Gly Lys Ile
             100                 105                 110        
 Thr Phe Glu Asp Phe Asn Glu Val Val Thr Asp Trp Ile Leu Glu Arg
         115                 120                 125            
 Asp Pro His Glu Glu Ile Leu Lys Ala Phe Lys Leu Phe Asp Asp Asp
     130                 135                 140                
 Asp Ser Gly Lys Ile Ser Leu Arg Asn Leu Arg Arg Val Ala Arg Glu
 145                 150                 155                 160
 Leu Gly Glu Asn Met Ser Asp Glu Glu Leu Arg Ala Met Ile Glu Glu
                 165                 170                 175    
 Phe Asp Lys Asp Gly Asp Gly Glu Ile Asn Gln Glu Glu Phe Ile Ala
             180                 185                 190        
 Ile Met Thr Gly Asp Ile
         195            



      <210> 2270
      <211> 858
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(858)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2270
 Asn Lys Leu Val Thr Glu Arg Gln Ile Leu Gly Asp Pro Thr Tyr Met
   1               5                  10                  15    
 Arg Gln Ala Asp Gly Arg Lys Val Leu Arg Ser Ser Ile Arg Glu Phe
              20                  25                  30        
 Leu Cys Ser Glu Ala Met Phe His Leu Gly Val Pro Thr Thr Arg Ala
          35                  40                  45            
 Gly Ala Cys Val Thr Ser Glu Ser Thr Val Val Arg Asp Val Phe Tyr
      50                  55                  60                
 Asp Gly Leu Asp Pro Leu Arg Phe Leu Ser Leu Gln Met Ser Thr Gln
  65                  70                  75                  80
 Gly Val Gln Ala Pro Ala Trp Arg Arg Asn Asp Ile Arg Val Gln Leu
                  85                  90                  95    
 Leu Asp Tyr Val Ile Ser Ser Phe Tyr Pro Glu Ile Gln Ala Ala His
             100                 105                 110        
 Ala Ser Asp Ser Val Gln Arg Asn Ala Ala Phe Phe Arg Glu Val Thr
         115                 120                 125            
 Arg Arg Thr Ala Arg Met Val Ala Glu Trp Gln Cys Val Gly Phe Cys
     130                 135                 140                
 His Gly Val Leu Asn Thr Asp Asn Met Ser Ile Leu Gly Leu Thr Ile
 145                 150                 155                 160
 Asp Tyr Gly Pro Phe Gly Phe Leu Asp Arg Tyr Asp Pro Asp His Val
                 165                 170                 175    
 Cys Asn Ala Ser Asp Asn Thr Gly Arg Tyr Ala Tyr Ser Lys Gln Pro
             180                 185                 190        
 Glu Val Cys Arg Trp Asn Leu Arg Lys Leu Ala Glu Ala Leu Gln Pro
         195                 200                 205            
 Glu Leu Pro Leu Glu Leu Gly Glu Ala Ile Leu Ala Glu Glu Phe Asp
     210                 215                 220                
 Ala Glu Phe Gln Arg His Tyr Leu Gln Lys Met Arg Arg Lys Leu Gly
 225                 230                 235                 240
 Leu Val Gln Val Glu Leu Glu Glu Asp Gly Ala Leu Val Ser Lys Leu
                 245                 250                 255    
 Leu Glu Thr Met His Leu Thr Gly Ala Asp Phe Thr Asn Thr Phe Tyr
             260                 265                 270        
 Leu Leu Ser Ser Phe Pro Val Glu Leu Glu Ser Pro Gly Leu Ala Glu
         275                 280                 285            
 Phe Leu Ala Arg Leu Met Glu Gln Cys Ala Ser Leu Glu Glu Leu Arg
     290                 295                 300                
 Leu Ala Phe Arg Pro Gln Met Asp Pro Arg Gln Leu Ser Met Met Leu
 305                 310                 315                 320
 Met Leu Ala Gln Ser Asn Pro Gln Leu Phe Ala Leu Met Gly Thr Arg
                 325                 330                 335    
 Ala Gly Ile Ala Arg Glu Leu Glu Arg Val Glu Gln Gln Ser Arg Leu
             340                 345                 350        
 Glu Gln Leu Ser Ala Ala Glu Leu Gln Ser Arg Asn Gln Gly His Trp
         355                 360                 365            
 Ala Asp Trp Leu Gln Ala Tyr Arg Ala Arg Leu Asp Lys Asp Leu Glu
     370                 375                 380                
 Gly Ala Gly Asp Ala Ala Ala Trp Gln Ala Glu His Val Arg Val Met
 385                 390                 395                 400
 His Ala Asn Asn Pro Lys Tyr Val Leu Arg Asn Tyr Ile Ala Gln Asn
                 405                 410                 415    
 Ala Ile Glu Ala Ala Glu Arg Gly Asp Phe Ser Glu Val Arg Arg Val
             420                 425                 430        
 Leu Lys Leu Leu Glu Thr Pro Tyr His Cys Glu Ala Gly Ala Ala Thr
         435                 440                 445            
 Asp Ala Glu Ala Thr Glu Ala Asp Gly Ala Asp Gly Arg Gln Arg Ser
     450                 455                 460                
 Tyr Ser Ser Lys Pro Pro Leu Trp Ala Ala Glu Leu Cys Val Thr Xaa
 465                 470                 475                 480
 Ser Ser Phe Tyr Pro Glu Ile Gln Ala Ala His Ala Ser Asp Ser Val
                 485                 490                 495    
 Gln Arg Asn Ala Ala Phe Phe Arg Glu Val Thr Arg Arg Thr Ala Arg
             500                 505                 510        
 Met Val Ala Glu Trp Gln Cys Val Gly Phe Cys His Gly Val Leu Asn
         515                 520                 525            
 Thr Asp Asn Met Ser Ile Leu Gly Leu Thr Ile Asp Tyr Gly Pro Phe
     530                 535                 540                
 Gly Phe Leu Asp Arg Tyr Asp Pro Asp His Val Cys Asn Ala Ser Asp
 545                 550                 555                 560
 Asn Thr Gly Arg Tyr Ala Tyr Ser Lys Gln Pro Glu Val Cys Arg Trp
                 565                 570                 575    
 Asn Leu Arg Lys Leu Ala Glu Ala Leu Gln Pro Glu Leu Pro Leu Glu
             580                 585                 590        
 Leu Gly Glu Ala Ile Leu Ala Glu Glu Phe Asp Ala Glu Phe Gln Arg
         595                 600                 605            
 His Tyr Leu Gln Lys Met Arg Arg Lys Leu Gly Leu Val Gln Val Glu
     610                 615                 620                
 Leu Glu Glu Asp Gly Ala Leu Val Ser Lys Leu Leu Glu Thr Met His
 625                 630                 635                 640
 Leu Thr Gly Ala Asp Phe Thr Asn Thr Phe Tyr Leu Leu Ser Ser Phe
                 645                 650                 655    
 Pro Val Glu Leu Glu Ser Pro Gly Leu Ala Glu Phe Leu Ala Arg Leu
             660                 665                 670        
 Met Glu Gln Cys Ala Ser Leu Glu Glu Leu Arg Leu Ala Phe Arg Pro
         675                 680                 685            
 Gln Met Asp Pro Arg Gln Leu Ser Met Met Leu Met Leu Ala Gln Ser
     690                 695                 700                
 Asn Pro Gln Leu Phe Ala Leu Met Gly Thr Arg Ala Gly Ile Ala Arg
 705                 710                 715                 720
 Glu Leu Glu Arg Val Glu Gln Gln Ser Arg Leu Glu Gln Leu Ser Ala
                 725                 730                 735    
 Ala Glu Leu Gln Ser Arg Asn Gln Gly His Trp Ala Asp Trp Leu Gln
             740                 745                 750        
 Ala Tyr Arg Ala Arg Leu Asp Lys Asp Leu Glu Gly Ala Gly Asp Ala
         755                 760                 765            
 Ala Ala Trp Gln Ala Glu His Val Arg Val Met His Ala Asn Asn Pro
     770                 775                 780                
 Lys Tyr Val Leu Arg Asn Tyr Ile Ala Gln Asn Ala Ile Glu Ala Ala
 785                 790                 795                 800
 Glu Arg Gly Asp Phe Ser Glu Val Arg Arg Val Leu Lys Leu Leu Glu
                 805                 810                 815    
 Thr Pro Tyr His Cys Glu Ala Gly Ala Ala Thr Asp Ala Glu Ala Thr
             820                 825                 830        
 Glu Ala Asp Gly Ala Asp Gly Arg Gln Arg Ser Tyr Ser Ser Lys Pro
         835                 840                 845            
 Pro Leu Trp Ala Ala Glu Leu Cys Val Thr
     850                 855            



      <210> 2271
      <211> 858
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(858)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2271
 Asn Lys Leu Val Thr Glu Arg Gln Ile Leu Gly Asp Pro Thr Tyr Met
   1               5                  10                  15    
 Arg Gln Ala Asp Gly Arg Lys Val Leu Arg Ser Ser Ile Arg Glu Phe
              20                  25                  30        
 Leu Cys Ser Glu Ala Met Phe His Leu Gly Val Pro Thr Thr Arg Ala
          35                  40                  45            
 Gly Ala Cys Val Thr Ser Glu Ser Thr Val Val Arg Asp Val Phe Tyr
      50                  55                  60                
 Asp Gly Leu Asp Pro Leu Arg Phe Leu Ser Leu Gln Met Ser Thr Gln
  65                  70                  75                  80
 Gly Val Gln Ala Pro Ala Trp Arg Arg Asn Asp Ile Arg Val Gln Leu
                  85                  90                  95    
 Leu Asp Tyr Val Ile Ser Ser Phe Tyr Pro Glu Ile Gln Ala Ala His
             100                 105                 110        
 Ala Ser Asp Ser Val Gln Arg Asn Ala Ala Phe Phe Arg Glu Val Thr
         115                 120                 125            
 Arg Arg Thr Ala Arg Met Val Ala Glu Trp Gln Cys Val Gly Phe Cys
     130                 135                 140                
 His Gly Val Leu Asn Thr Asp Asn Met Ser Ile Leu Gly Leu Thr Ile
 145                 150                 155                 160
 Asp Tyr Gly Pro Phe Gly Phe Leu Asp Arg Tyr Asp Pro Asp His Val
                 165                 170                 175    
 Cys Asn Ala Ser Asp Asn Thr Gly Arg Tyr Ala Tyr Ser Lys Gln Pro
             180                 185                 190        
 Glu Val Cys Arg Trp Asn Leu Arg Lys Leu Ala Glu Ala Leu Gln Pro
         195                 200                 205            
 Glu Leu Pro Leu Glu Leu Gly Glu Ala Ile Leu Ala Glu Glu Phe Asp
     210                 215                 220                
 Ala Glu Phe Gln Arg His Tyr Leu Gln Lys Met Arg Arg Lys Leu Gly
 225                 230                 235                 240
 Leu Val Gln Val Glu Leu Glu Glu Asp Gly Ala Leu Val Ser Lys Leu
                 245                 250                 255    
 Leu Glu Thr Met His Leu Thr Gly Ala Asp Phe Thr Asn Thr Phe Tyr
             260                 265                 270        
 Leu Leu Ser Ser Phe Pro Val Glu Leu Glu Ser Pro Gly Leu Ala Glu
         275                 280                 285            
 Phe Leu Ala Arg Leu Met Glu Gln Cys Ala Ser Leu Glu Glu Leu Arg
     290                 295                 300                
 Leu Ala Phe Arg Pro Gln Met Asp Pro Arg Gln Leu Ser Met Met Leu
 305                 310                 315                 320
 Met Leu Ala Gln Ser Asn Pro Gln Leu Phe Ala Leu Met Gly Thr Arg
                 325                 330                 335    
 Ala Gly Ile Ala Arg Glu Leu Glu Arg Val Glu Gln Gln Ser Arg Leu
             340                 345                 350        
 Glu Gln Leu Ser Ala Ala Glu Leu Gln Ser Arg Asn Gln Gly His Trp
         355                 360                 365            
 Ala Asp Trp Leu Gln Ala Tyr Arg Ala Arg Leu Asp Lys Asp Leu Glu
     370                 375                 380                
 Gly Ala Gly Asp Ala Ala Ala Trp Gln Ala Glu His Val Arg Val Met
 385                 390                 395                 400
 His Ala Asn Asn Pro Lys Tyr Val Leu Arg Asn Tyr Ile Ala Gln Asn
                 405                 410                 415    
 Ala Ile Glu Ala Ala Glu Arg Gly Asp Phe Ser Glu Val Arg Arg Val
             420                 425                 430        
 Leu Lys Leu Leu Glu Thr Pro Tyr His Cys Glu Ala Gly Ala Ala Thr
         435                 440                 445            
 Asp Ala Glu Ala Thr Glu Ala Asp Gly Ala Asp Gly Arg Gln Arg Ser
     450                 455                 460                
 Tyr Ser Ser Lys Pro Pro Leu Trp Ala Ala Glu Leu Cys Val Thr Xaa
 465                 470                 475                 480
 Ser Ser Phe Tyr Pro Glu Ile Gln Ala Ala His Ala Ser Asp Ser Val
                 485                 490                 495    
 Gln Arg Asn Ala Ala Phe Phe Arg Glu Val Thr Arg Arg Thr Ala Arg
             500                 505                 510        
 Met Val Ala Glu Trp Gln Cys Val Gly Phe Cys His Gly Val Leu Asn
         515                 520                 525            
 Thr Asp Asn Met Ser Ile Leu Gly Leu Thr Ile Asp Tyr Gly Pro Phe
     530                 535                 540                
 Gly Phe Leu Asp Arg Tyr Asp Pro Asp His Val Cys Asn Ala Ser Asp
 545                 550                 555                 560
 Asn Thr Gly Arg Tyr Ala Tyr Ser Lys Gln Pro Glu Val Cys Arg Trp
                 565                 570                 575    
 Asn Leu Arg Lys Leu Ala Glu Ala Leu Gln Pro Glu Leu Pro Leu Glu
             580                 585                 590        
 Leu Gly Glu Ala Ile Leu Ala Glu Glu Phe Asp Ala Glu Phe Gln Arg
         595                 600                 605            
 His Tyr Leu Gln Lys Met Arg Arg Lys Leu Gly Leu Val Gln Val Glu
     610                 615                 620                
 Leu Glu Glu Asp Gly Ala Leu Val Ser Lys Leu Leu Glu Thr Met His
 625                 630                 635                 640
 Leu Thr Gly Ala Asp Phe Thr Asn Thr Phe Tyr Leu Leu Ser Ser Phe
                 645                 650                 655    
 Pro Val Glu Leu Glu Ser Pro Gly Leu Ala Glu Phe Leu Ala Arg Leu
             660                 665                 670        
 Met Glu Gln Cys Ala Ser Leu Glu Glu Leu Arg Leu Ala Phe Arg Pro
         675                 680                 685            
 Gln Met Asp Pro Arg Gln Leu Ser Met Met Leu Met Leu Ala Gln Ser
     690                 695                 700                
 Asn Pro Gln Leu Phe Ala Leu Met Gly Thr Arg Ala Gly Ile Ala Arg
 705                 710                 715                 720
 Glu Leu Glu Arg Val Glu Gln Gln Ser Arg Leu Glu Gln Leu Ser Ala
                 725                 730                 735    
 Ala Glu Leu Gln Ser Arg Asn Gln Gly His Trp Ala Asp Trp Leu Gln
             740                 745                 750        
 Ala Tyr Arg Ala Arg Leu Asp Lys Asp Leu Glu Gly Ala Gly Asp Ala
         755                 760                 765            
 Ala Ala Trp Gln Ala Glu His Val Arg Val Met His Ala Asn Asn Pro
     770                 775                 780                
 Lys Tyr Val Leu Arg Asn Tyr Ile Ala Gln Asn Ala Ile Glu Ala Ala
 785                 790                 795                 800
 Glu Arg Gly Asp Phe Ser Glu Val Arg Arg Val Leu Lys Leu Leu Glu
                 805                 810                 815    
 Thr Pro Tyr His Cys Glu Ala Gly Ala Ala Thr Asp Ala Glu Ala Thr
             820                 825                 830        
 Glu Ala Asp Gly Ala Asp Gly Arg Gln Arg Ser Tyr Ser Ser Lys Pro
         835                 840                 845            
 Pro Leu Trp Ala Ala Glu Leu Cys Val Thr
     850                 855            



      <210> 2272
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 2272
 Phe Phe Leu Pro Leu Leu Ile Ile Ile Tyr Cys Tyr Ile Phe Ile Phe
   1               5                  10                  15    
 Arg Ala Met Arg Glu Thr Gly Arg Ala Leu Gln Thr Phe Gly Ala Cys
              20                  25                  30        
 Lys Gly Asn Gly Glu Ser Leu Trp Gln Arg Gln Arg Leu Gln Ser Glu
          35                  40                  45            
 Cys Lys Met Ala Lys Ile Met Leu Leu Val Ile Leu Leu Phe Val Leu
      50                  55                  60                
 Ser Trp Ala Pro Tyr Ser Ala Val Ala Leu Val Ala Phe Ala Gly Tyr
  65                  70                  75                  80
 Ala His Val Leu Thr Pro Tyr Met Ser Ser Val Pro Ala Val Ile Ala
                  85                  90                  95    
 Lys Ala Ser Ala Ile His Asn Pro Ile Ile Tyr Ala Ile Thr His Pro
             100                 105                 110        
 Lys Tyr Arg Val Ala Ile Ala Gln His Leu Pro Cys Leu Gly Val Leu
         115                 120                 125            
 Leu
    



      <210> 2273
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 2273
 Met Thr Thr Thr Phe Pro Pro Arg Lys Met Val Ala Gln Phe Leu Leu
   1               5                  10                  15    
 Val Ala Gly Asn Val Ala Asn Ile Thr Thr Val Ser Leu Trp Glu Glu
              20                  25                  30        
 Phe Ser Ser Ser Asp Leu Ala Asp Leu Arg Phe Leu Asp Met Ser Gln
          35                  40                  45            
 Asn Gln Phe Gln Tyr Leu Pro Asp Gly Phe Leu Arg Lys Met Pro Ser
      50                  55                  60                
 Leu Ser His Leu Asn Leu His Gln Asn Cys Leu Met Thr Leu His Ile
  65                  70                  75                  80
 Arg Glu His Glu Pro Pro Gly Ala Leu Thr Glu Leu Asp Leu Ser His
                  85                  90                  95    
 Asn Gln Leu Ser Glu Leu His Leu Ala Pro Gly Leu Ala Ser Cys Leu
             100                 105                 110        
 Gly Ser Leu Arg Leu Phe Asn Leu Ser Ser Asn Gln Leu Leu Gly Val
         115                 120                 125            
 Pro Pro Gly Pro Leu Tyr
     130                



      <210> 2274
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 2274
 Phe Leu Leu Leu Arg Ser Ala Ser Pro Glu His Thr Cys Val Lys Ser
   1               5                  10                  15    
 Lys Thr Leu Asp Pro Met Val Ile Phe Phe Thr Ser Gly Thr Thr Gly
              20                  25                  30        
 Phe Pro Lys Met Ala Lys His Ser His Gly Leu Ala Leu Gln Pro Ser
          35                  40                  45            
 Phe Pro Gly Ser Arg Lys Leu Arg Ser Leu Lys Thr Ser Asp Val Ser
      50                  55                  60                
 Trp Cys Leu Ser Asp Ser Gly Trp Ile Val Ala Thr Ile Trp Thr Leu
  65                  70                  75                  80
 Val Glu Pro Trp Thr Ala Gly Cys Thr Val Phe Ile His His Leu Pro
                  85                  90                  95    
 Gln Phe Asp Thr Lys Val Ile Ile Gln Thr Leu Val Lys Tyr Pro Ile
             100                 105                 110        
 Asn His Phe Trp Gly Val Ser Ser Ile Tyr Arg Met Ile Leu Gln Gln
         115                 120                 125            
 Asp Phe Thr Ser Ile Arg Phe Pro Ala Leu Glu
     130                 135                



      <210> 2275
      <211> 412
      <212> PRT
      <213> Homo sapiens


      <400> 2275
 Leu Thr Lys Met His Leu Thr Glu Asn Pro His Pro Gln Val Thr His
   1               5                  10                  15    
 Val Ser Ser Ser Gln Ser Gly Cys Ser Ile Ala Ser Asp Ser Gly Ser
              20                  25                  30        
 Ser Ser Leu Ser Asp Ile Tyr Gln Ala Thr Glu Ser Glu Val Gly Asp
          35                  40                  45            
 Val Asp Leu Thr Arg Leu Pro Glu Gly Pro Val Asp Ser Glu Asp Asp
      50                  55                  60                
 Glu Glu Glu Asp Glu Glu Ile Asp Arg Thr Asp Pro Leu Gln Gly Arg
  65                  70                  75                  80
 Asp Leu Val Arg Glu Cys Leu Glu Lys Glu Pro Ala Asp Lys Thr Asp
                  85                  90                  95    
 Asp Asp Ile Glu Gln Leu Leu Glu Phe Met His Gln Leu Pro Ala Phe
             100                 105                 110        
 Ala Asn Met Thr Met Ser Val Arg Arg Glu Leu Cys Ser Val Met Ile
         115                 120                 125            
 Phe Glu Val Val Glu Gln Ala Gly Ala Ile Ile Leu Glu Asp Gly Gln
     130                 135                 140                
 Glu Leu Asp Ser Trp Tyr Val Ile Leu Asn Gly Thr Val Glu Ile Ser
 145                 150                 155                 160
 His Pro Asp Gly Lys Val Glu Asn Leu Phe Met Gly Asn Ser Phe Gly
                 165                 170                 175    
 Ile Thr Pro Thr Leu Asp Lys Gln Tyr Met His Gly Ile Val Arg Thr
             180                 185                 190        
 Lys Val Asp Asp Cys Gln Phe Val Cys Ile Ala Gln Gln Asp Tyr Trp
         195                 200                 205            
 Arg Ile Leu Asn His Val Glu Lys Asn Thr His Lys Val Glu Glu Glu
     210                 215                 220                
 Gly Glu Ile Val Met Val His Glu His Arg Glu Leu Asp Arg Ser Gly
 225                 230                 235                 240
 Thr Arg Lys Gly His Ile Val Ile Lys Ala Thr Pro Glu Arg Leu Ile
                 245                 250                 255    
 Met His Leu Ile Glu Glu His Ser Ile Val Asp Pro Thr Tyr Ile Glu
             260                 265                 270        
 Asp Phe Leu Leu Thr Tyr Arg Thr Phe Leu Glu Ser Pro Leu Asp Val
         275                 280                 285            
 Gly Ile Lys Leu Leu Glu Trp Phe Lys Ile Asp Ser Leu Arg Asp Lys
     290                 295                 300                
 Val Thr Arg Ile Val Leu Leu Trp Val Asn Asn His Phe Asn Asp Phe
 305                 310                 315                 320
 Glu Gly Asp Pro Ala Met Thr Arg Phe Leu Glu Glu Phe Glu Lys Asn
                 325                 330                 335    
 Leu Glu Asp Thr Lys Met Asn Gly His Leu Arg Leu Leu Asn Ile Ala
             340                 345                 350        
 Cys Ala Ala Lys Ala Lys Trp Arg Gln Val Val Leu Gln Lys Ala Ser
         355                 360                 365            
 Arg Glu Ser Pro Leu Gln Phe Ser Leu Asn Gly Gly Ser Glu Lys Gly
     370                 375                 380                
 Phe Gly Ile Phe Val Glu Gly Val Glu Pro Gly Ser Lys Ala Ala Asp
 385                 390                 395                 400
 Ser Gly Leu Lys Arg Gly Asp Gln Ile Met Glu Val
                 405                 410        



      <210> 2276
      <211> 412
      <212> PRT
      <213> Homo sapiens


      <400> 2276
 Leu Thr Lys Met His Leu Thr Glu Asn Pro His Pro Gln Val Thr His
   1               5                  10                  15    
 Val Ser Ser Ser Gln Ser Gly Cys Ser Ile Ala Ser Asp Ser Gly Ser
              20                  25                  30        
 Ser Ser Leu Ser Asp Ile Tyr Gln Ala Thr Glu Ser Glu Val Gly Asp
          35                  40                  45            
 Val Asp Leu Thr Arg Leu Pro Glu Gly Pro Val Asp Ser Glu Asp Asp
      50                  55                  60                
 Glu Glu Glu Asp Glu Glu Ile Asp Arg Thr Asp Pro Leu Gln Gly Arg
  65                  70                  75                  80
 Asp Leu Val Arg Glu Cys Leu Glu Lys Glu Pro Ala Asp Lys Thr Asp
                  85                  90                  95    
 Asp Asp Ile Glu Gln Leu Leu Glu Phe Met His Gln Leu Pro Ala Phe
             100                 105                 110        
 Ala Asn Met Thr Met Ser Val Arg Arg Glu Leu Cys Ser Val Met Ile
         115                 120                 125            
 Phe Glu Val Val Glu Gln Ala Gly Ala Ile Ile Leu Glu Asp Gly Gln
     130                 135                 140                
 Glu Leu Asp Ser Trp Tyr Val Ile Leu Asn Gly Thr Val Glu Ile Ser
 145                 150                 155                 160
 His Pro Asp Gly Lys Val Glu Asn Leu Phe Met Gly Asn Ser Phe Gly
                 165                 170                 175    
 Ile Thr Pro Thr Leu Asp Lys Gln Tyr Met His Gly Ile Val Arg Thr
             180                 185                 190        
 Lys Val Asp Asp Cys Gln Phe Val Cys Ile Ala Gln Gln Asp Tyr Trp
         195                 200                 205            
 Arg Ile Leu Asn His Val Glu Lys Asn Thr His Lys Val Glu Glu Glu
     210                 215                 220                
 Gly Glu Ile Val Met Val His Glu His Arg Glu Leu Asp Arg Ser Gly
 225                 230                 235                 240
 Thr Arg Lys Gly His Ile Val Ile Lys Ala Thr Pro Glu Arg Leu Ile
                 245                 250                 255    
 Met His Leu Ile Glu Glu His Ser Ile Val Asp Pro Thr Tyr Ile Glu
             260                 265                 270        
 Asp Phe Leu Leu Thr Tyr Arg Thr Phe Leu Glu Ser Pro Leu Asp Val
         275                 280                 285            
 Gly Ile Lys Leu Leu Glu Trp Phe Lys Ile Asp Ser Leu Arg Asp Lys
     290                 295                 300                
 Val Thr Arg Ile Val Leu Leu Trp Val Asn Asn His Phe Asn Asp Phe
 305                 310                 315                 320
 Glu Gly Asp Pro Ala Met Thr Arg Phe Leu Glu Glu Phe Glu Lys Asn
                 325                 330                 335    
 Leu Glu Asp Thr Lys Met Asn Gly His Leu Arg Leu Leu Asn Ile Ala
             340                 345                 350        
 Cys Ala Ala Lys Ala Lys Trp Arg Gln Val Val Leu Gln Lys Ala Ser
         355                 360                 365            
 Arg Glu Ser Pro Leu Gln Phe Ser Leu Asn Gly Gly Ser Glu Lys Gly
     370                 375                 380                
 Phe Gly Ile Phe Val Glu Gly Val Glu Pro Gly Ser Lys Ala Ala Asp
 385                 390                 395                 400
 Ser Gly Leu Lys Arg Gly Asp Gln Ile Met Glu Val
                 405                 410        



      <210> 2277
      <211> 264
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(264)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2277
 Phe Arg Gly Phe Leu Asp Arg Gly Asp Cys Ala Ala Leu Pro Cys Thr
   1               5                  10                  15    
 Tyr Pro His Ser Pro Cys Ser His Xaa Gly Gly Asn Cys Leu Pro Ser
              20                  25                  30        
 Leu Leu Thr Arg Pro Cys Val Lys Ala Xaa Pro Gln Met Ser Gly Arg
          35                  40                  45            
 Lys Ser Ser Met Arg Arg Trp Arg Arg Gln Ser Arg Leu Thr Ala Gly
      50                  55                  60                
 Thr Ser Ser Xaa Thr Pro Thr Ser Ser Thr Met Cys Xaa Ala Leu Val
  65                  70                  75                  80
 Gly Ser Ser Thr Trp Asn Cys Met Leu Gln Ala Gly Ser Thr Ala Pro
                  85                  90                  95    
 Gly Ala Gly Thr Pro Gly Ser Arg Pro Thr Trp Ser Ser Ser Ser Thr
             100                 105                 110        
 Cys Ser Trp Thr Ala Pro Ser Gly Arg Ala Arg Cys Ala Cys Ala Ser
         115                 120                 125            
 Ser Ser Ser Cys Ala Met Ser Ala Ala Arg Arg Gly Trp Thr Ser Pro
     130                 135                 140                
 Ala Cys Trp Arg Arg Thr Ser Arg Ala Trp Trp Thr Thr Ser Ser Pro
 145                 150                 155                 160
 Ala Cys Ala Ser Ser Ala Thr Ala Ser Val Ala Ala Ser Thr Ala Ser
                 165                 170                 175    
 Thr Trp Pro Ala Ala Arg Thr Thr Gly Gly Thr Ala Glu Ser Ser Ala
             180                 185                 190        
 Arg Pro Ala Arg Arg Ala Ser Cys Thr Gly Ser Pro Ala Arg Ser Cys
         195                 200                 205            
 Trp Arg Arg Arg Arg Pro Pro Thr Pro Ser Pro Gly Arg Pro Ala Pro
     210                 215                 220                
 Pro Ser Arg Arg Thr Arg Arg Ala Gln Ala Gly Thr Ser Ala Leu Ser
 225                 230                 235                 240
 Pro Gly Ala Cys Phe Gly Pro Arg Ser Cys Cys Xaa Ser Ser Thr Cys
                 245                 250                 255    
 Ser Ser Leu Ser Val Ala Pro Tyr
             260                



      <210> 2278
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 2278
 Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile
   1               5                  10                  15    
 Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro
              20                  25                  30        
 His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe
          35                  40                  45            
 Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe
      50                  55                  60                
 Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu
  65                  70                  75                  80
 Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe
                  85                  90                  95    
 His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr
             100                 105                 110        
 Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg
         115                 120                 125            
 Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp
     130                 135                 140                
 Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Pro Pro Phe Gly Ser
 145                 150                 155                 160
 Arg Asp Met Gly Lys Ala Phe Pro Lys Trp Asp Ser Pro Thr Pro Gly
                 165                 170                 175    
 Gly Asp Arg Pro Ser Ser Phe Glu Leu Leu Pro
             180                 185        



      <210> 2279
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 2279
 Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile
   1               5                  10                  15    
 Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro
              20                  25                  30        
 His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe
          35                  40                  45            
 Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe
      50                  55                  60                
 Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu
  65                  70                  75                  80
 Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe
                  85                  90                  95    
 His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr
             100                 105                 110        
 Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg
         115                 120                 125            
 Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp
     130                 135                 140                
 Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Pro Pro Phe Gly Ser
 145                 150                 155                 160
 Arg Asp Met Gly Lys Ala Phe Pro Lys Trp Asp Ser Pro Thr Pro Gly
                 165                 170                 175    
 Gly Asp Arg Pro Ser Ser Phe Glu Leu Leu Pro
             180                 185        



      <210> 2280
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 2280
 Val Leu Pro Thr Ala Gln Gly Lys Leu Tyr Gln Asp Asp Leu Lys Val
   1               5                  10                  15    
 Asn Pro Ala Asn Val Ser His Leu Val Ser Pro Phe Thr Trp Gln Gly
              20                  25                  30        
 Pro Gly Gly His Leu Lys Ala Pro Gln Trp Thr Thr Ser Ser Leu Phe
          35                  40                  45            
 Pro Phe Gln Ile Arg Asn Val Gly Thr Gly Leu Cys Ala Asp Thr Lys
      50                  55                  60                
 His Gly Ala Leu Gly Ser Pro Leu Arg Leu Glu Gly Cys Val Arg Gly
  65                  70                  75                  80
 Arg Gly Glu Ala Ala Trp Asn Asn Met Gln Val Arg Ala Ala Pro Gln
                  85                  90                  95    
 Gly Leu Ala Ala Arg Phe Ser Glu Thr Ser Ala Ala Trp Gly Ala Asp
             100                 105                 110        
 Thr Ala Ser Trp Glu Gly Glu Ala Trp Val Ser Asp Lys
         115                 120                 125



      <210> 2281
      <211> 331
      <212> PRT
      <213> Homo sapiens


      <400> 2281
 Met Arg Asp Leu Phe Gly Thr Arg Leu Arg Arg Ala Glu Asp Val Phe
   1               5                  10                  15    
 Pro Pro Val Ile Gly Val Ala Ala His Lys Gly Gly Val Tyr Lys Thr
              20                  25                  30        
 Ser Val Ser Val His Leu Ala Gln Asp Leu Ala Leu Lys Gly Leu Arg
          35                  40                  45            
 Val Leu Leu Val Glu Gly Asn Asp Pro Gln Gly Thr Ala Ser Met Tyr
      50                  55                  60                
 His Gly Trp Val Pro Asp Leu His Ile His Ala Glu Asp Thr Leu Leu
  65                  70                  75                  80
 Pro Phe Tyr Leu Gly Glu Lys Asp Asp Val Thr Tyr Ala Ile Lys Pro
                  85                  90                  95    
 Thr Cys Trp Pro Gly Leu Asp Ile Ile Pro Ser Cys Leu Ala Leu His
             100                 105                 110        
 Arg Ile Glu Thr Glu Leu Met Gly Lys Phe Asp Glu Gly Lys Leu Pro
         115                 120                 125            
 Thr Asp Pro His Leu Met Leu Arg Leu Ala Ile Glu Thr Val Ala His
     130                 135                 140                
 Asp Tyr Asp Val Ile Val Ile Asp Ser Ala Pro Asn Leu Gly Ile Gly
 145                 150                 155                 160
 Thr Ile Asn Val Val Cys Ala Ala Asp Val Leu Ile Val Pro Thr Pro
                 165                 170                 175    
 Ala Glu Leu Phe Asp Tyr Thr Ser Ala Leu Gln Phe Phe Asp Met Leu
             180                 185                 190        
 Arg Asp Leu Leu Lys Asn Val Asp Leu Lys Gly Phe Glu Pro Asp Asp
         195                 200                 205            
 Leu Lys Lys Ser Phe Lys Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu
     210                 215                 220                
 Glu Phe Phe Arg Ile Phe Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe
 225                 230                 235                 240
 Val Val Ala Ser Glu Thr Ser Asp Cys Val Val Ser Ser Thr Leu Ser
                 245                 250                 255    
 Pro Glu Lys Val Leu Arg Ala Ser Trp Lys Arg Asp Ser Asp Asn Ser
             260                 265                 270        
 Leu Lys Ser Leu Ser Pro Thr Gln Ile Arg Leu Gly Glu Val Leu Thr
         275                 280                 285            
 Pro Val Met Ser Ala Phe Trp Glu Ala Glu Val Trp Asn Ser Gly Asp
     290                 295                 300                
 Ser Asp Asp Met Ala Leu Asp Phe Asp Cys Thr Ser Ser Glu Val Asp
 305                 310                 315                 320
 Ala Glu Ser Thr Asn Arg Lys Val Leu Arg Pro
                 325                 330    



      <210> 2282
      <211> 193
      <212> PRT
      <213> Homo sapiens


      <400> 2282
 Ser Leu Tyr Gln Phe Ser Val Val Glu Thr Ala Gly Pro Gly Thr Leu
   1               5                  10                  15    
 Val Gly Arg Leu Arg Ala Gln Asp Pro Asp Leu Gly Asp Asn Ala Leu
              20                  25                  30        
 Met Ala Tyr Ser Ile Leu Asp Gly Glu Gly Ser Glu Ala Phe Ser Ile
          35                  40                  45            
 Ser Thr Asp Leu Gln Gly Arg Asp Gly Leu Leu Thr Val Arg Lys Pro
      50                  55                  60                
 Leu Asp Phe Glu Ser Gln Arg Ser Tyr Ser Phe Arg Val Glu Ala Thr
  65                  70                  75                  80
 Asn Thr Leu Ile Asp Pro Ala Tyr Leu Arg Arg Gly Pro Phe Lys Asp
                  85                  90                  95    
 Val Ala Ser Val Arg Val Ala Val Gln Asp Ala Pro Glu Pro Pro Ala
             100                 105                 110        
 Phe Thr Gln Ala Ala Tyr His Leu Thr Val Pro Glu Asn Lys Ala Pro
         115                 120                 125            
 Gly Thr Leu Val Gly Gln Ile Ser Ala Ala Asp Leu Asp Ser Pro Ala
     130                 135                 140                
 Ser Pro Ile Arg Tyr Ser Ile Leu Pro His Ser Asp Pro Glu Arg Cys
 145                 150                 155                 160
 Phe Ser Ile Gln Pro Glu Glu Gly Thr Ile His Thr Ala Ala Pro Leu
                 165                 170                 175    
 Asp Arg Glu Ala Arg Ala Trp His Asn Leu Thr Val Leu Ala Thr Glu
             180                 185                 190        
 Leu
    



      <210> 2283
      <211> 193
      <212> PRT
      <213> Homo sapiens


      <400> 2283
 Ser Leu Tyr Gln Phe Ser Val Val Glu Thr Ala Gly Pro Gly Thr Leu
   1               5                  10                  15    
 Val Gly Arg Leu Arg Ala Gln Asp Pro Asp Leu Gly Asp Asn Ala Leu
              20                  25                  30        
 Met Ala Tyr Ser Ile Leu Asp Gly Glu Gly Ser Glu Ala Phe Ser Ile
          35                  40                  45            
 Ser Thr Asp Leu Gln Gly Arg Asp Gly Leu Leu Thr Val Arg Lys Pro
      50                  55                  60                
 Leu Asp Phe Glu Ser Gln Arg Ser Tyr Ser Phe Arg Val Glu Ala Thr
  65                  70                  75                  80
 Asn Thr Leu Ile Asp Pro Ala Tyr Leu Arg Arg Gly Pro Phe Lys Asp
                  85                  90                  95    
 Val Ala Ser Val Arg Val Ala Val Gln Asp Ala Pro Glu Pro Pro Ala
             100                 105                 110        
 Phe Thr Gln Ala Ala Tyr His Leu Thr Val Pro Glu Asn Lys Ala Pro
         115                 120                 125            
 Gly Thr Leu Val Gly Gln Ile Ser Ala Ala Asp Leu Asp Ser Pro Ala
     130                 135                 140                
 Ser Pro Ile Arg Tyr Ser Ile Leu Pro His Ser Asp Pro Glu Arg Cys
 145                 150                 155                 160
 Phe Ser Ile Gln Pro Glu Glu Gly Thr Ile His Thr Ala Ala Pro Leu
                 165                 170                 175    
 Asp Arg Glu Ala Arg Ala Trp His Asn Leu Thr Val Leu Ala Thr Glu
             180                 185                 190        
 Leu
    



      <210> 2284
      <211> 277
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(277)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2284
 Lys Asn Val Trp Lys Arg Trp Lys Lys Arg Phe Phe Val Leu Val Gln
   1               5                  10                  15    
 Val Ile Gln Tyr Thr Phe Ala Met Cys Ser Tyr Arg Glu Lys Lys Ala
              20                  25                  30        
 Glu Pro Gln Glu Leu Leu Gln Leu Asp Gly Tyr Thr Val Asp Tyr Thr
          35                  40                  45            
 Asp Pro Gln Pro Gly Leu Glu Gly Gly Arg Ala Phe Phe Asn Ala Val
      50                  55                  60                
 Lys Glu Gly Asp Thr Val Ile Phe Ala Ser Asp Asp Glu Gln Asp Arg
  65                  70                  75                  80
 Ile Leu Trp Val Gln Ala Met Tyr Arg Ala Thr Gly Gln Ser His Lys
                  85                  90                  95    
 Pro Val Pro Pro Thr Gln Val Gln Lys Leu Asn Ala Lys Gly Gly Asn
             100                 105                 110        
 Val Pro Gln Leu Asp Ala Pro Ile Ser Gln Phe Tyr Ala Asp Arg Ala
         115                 120                 125            
 Gln Lys His Gly Met Asp Glu Phe Ile Ser Ser Asn Pro Cys Asn Phe
     130                 135                 140                
 Asp His Ala Ser Leu Phe Glu Met Val Gln Arg Leu Thr Leu Asp His
 145                 150                 155                 160
 Arg Leu Asn Asp Ser Tyr Ser Cys Leu Gly Trp Phe Ser Pro Gly Gln
                 165                 170                 175    
 Val Phe Val Leu Asp Glu Tyr Cys Ala Arg Asn Gly Val Arg Gly Cys
             180                 185                 190        
 His Arg His Leu Cys Tyr Leu Arg Asp Leu Leu Glu Arg Ala Glu Asn
         195                 200                 205            
 Gly Ala Met Ile Asp Pro Thr Leu Xaa His Tyr Ser Phe Ala Phe Cys
     210                 215                 220                
 Ala Ser His Val His Gly Asn Arg Pro Asp Gly Ile Gly Asn Cys Xaa
 225                 230                 235                 240
 Leu Leu Lys Lys Arg Asn Val Phe Xaa Arg Lys Ser Lys Glu Glu Xaa
                 245                 250                 255    
 Ser Xaa Val Leu Leu Arg Lys Ile Arg Leu Gln His Phe Arg Xaa Leu
             260                 265                 270        
 Leu Phe Pro Phe Gly
         275        



      <210> 2285
      <211> 102
      <212> PRT
      <213> Homo sapiens


      <400> 2285
 Met Gln Pro Ser Gly Leu Glu Gly Pro Gly Thr Phe Gly Arg Trp Pro
   1               5                  10                  15    
 Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Val Thr Cys
              20                  25                  30        
 Ala Tyr Thr Thr Pro Gly Pro Pro Arg Ala Leu Thr Thr Leu Gly Ala
          35                  40                  45            
 Pro Arg Ala His Thr Met Pro Gly Thr Tyr Ala Pro Ser Thr Thr Leu
      50                  55                  60                
 Ser Ser Pro Ser Thr Gln Gly Leu Gln Glu Gln Ala Arg Ala Leu Met
  65                  70                  75                  80
 Arg Asp Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro Leu Val Leu
                  85                  90                  95    
 Arg Gln Val Tyr His Asn
             100        



      <210> 2286
      <211> 424
      <212> PRT
      <213> Homo sapiens


      <400> 2286
 Met Ser Leu Thr Ile Trp Thr Val Cys Gly Val Leu Ser Leu Phe Gly
   1               5                  10                  15    
 Ala Leu Ser Tyr Ala Glu Leu Gly Thr Thr Ile Lys Lys Ser Gly Gly
              20                  25                  30        
 His Tyr Thr Tyr Ile Leu Glu Val Phe Gly Pro Leu Pro Ala Phe Val
          35                  40                  45            
 Arg Val Trp Val Glu Leu Leu Ile Ile Arg Pro Ala Ala Thr Ala Val
      50                  55                  60                
 Ile Ser Leu Ala Phe Gly Arg Tyr Ile Leu Glu Pro Phe Phe Ile Gln
  65                  70                  75                  80
 Cys Glu Ile Pro Glu Leu Ala Ile Lys Leu Ile Thr Ala Val Gly Ile
                  85                  90                  95    
 Thr Val Val Met Val Leu Asn Ser Met Ser Val Ser Trp Ser Ala Arg
             100                 105                 110        
 Ile Gln Ile Phe Leu Thr Phe Cys Lys Leu Thr Ala Ile Leu Ile Ile
         115                 120                 125            
 Ile Val Pro Gly Val Met Gln Leu Ile Lys Gly Gln Thr Gln Asn Phe
     130                 135                 140                
 Lys Asp Ala Phe Ser Gly Arg Asp Ser Ser Ile Thr Arg Leu Pro Leu
 145                 150                 155                 160
 Ala Phe Tyr Tyr Gly Met Tyr Ala Tyr Ala Gly Trp Phe Tyr Leu Asn
                 165                 170                 175    
 Phe Val Thr Glu Glu Val Glu Asn Pro Glu Lys Thr Ile Pro Leu Ala
             180                 185                 190        
 Ile Cys Ile Ser Met Ala Ile Val Thr Ile Gly Tyr Val Leu Thr Asn
         195                 200                 205            
 Val Ala Tyr Phe Thr Thr Ile Asn Ala Glu Glu Leu Leu Leu Ser Asn
     210                 215                 220                
 Ala Val Ala Val Thr Phe Ser Glu Arg Leu Leu Gly Asn Phe Ser Leu
 225                 230                 235                 240
 Ala Val Pro Ile Phe Val Ala Leu Ser Cys Phe Gly Ser Met Asn Gly
                 245                 250                 255    
 Gly Val Phe Ala Val Ser Arg Leu Phe Tyr Val Ala Ser Arg Glu Gly
             260                 265                 270        
 His Leu Pro Glu Ile Leu Ser Met Ile His Val Arg Lys His Thr Pro
         275                 280                 285            
 Leu Pro Ala Val Ile Val Leu His Pro Leu Thr Met Ile Met Leu Phe
     290                 295                 300                
 Ser Gly Asp Leu Asp Ser Leu Leu Asn Phe Leu Ser Phe Ala Arg Trp
 305                 310                 315                 320
 Leu Phe Ile Gly Leu Ala Val Ala Gly Leu Ile Tyr Leu Arg Tyr Lys
                 325                 330                 335    
 Cys Pro Asp Met His Arg Pro Phe Lys Val Pro Leu Phe Ile Pro Ala
             340                 345                 350        
 Leu Phe Ser Phe Thr Cys Leu Phe Met Val Ala Leu Ser Leu Tyr Ser
         355                 360                 365            
 Asp Pro Phe Ser Thr Gly Ile Gly Phe Val Ile Thr Leu Thr Gly Val
     370                 375                 380                
 Pro Ala Tyr Tyr Leu Phe Ile Ile Trp Asp Lys Lys Pro Arg Trp Phe
 385                 390                 395                 400
 Arg Ile Met Ser Glu Lys Ile Thr Arg Thr Leu Gln Ile Ile Leu Glu
                 405                 410                 415    
 Val Val Pro Glu Glu Asp Lys Leu
             420                



      <210> 2287
      <211> 921
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(921)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2287
 Ser Pro Gly Gly Arg Thr Pro Ala Ala Arg Asp Ser Val Val Arg Glu
   1               5                  10                  15    
 Val Ile Gln Asn Ser Lys Glu Val Ser Ile Val Tyr Trp Gln Glu Lys
              20                  25                  30        
 Asn Cys Cys Ala Ser Ser Ala Val Arg Cys Lys Leu Ser Arg Arg Gly
          35                  40                  45            
 Asp Gly Gln Ala Xaa Cys Xaa Glu Ile Asn Gln Asn Leu Ala Glu Glu
      50                  55                  60                
 Ala Gly Leu Asn Ile Thr His Ile Cys Leu Ala Pro Asp Ser Ser Glu
  65                  70                  75                  80
 Ala Glu Ile Ile Asp Glu Ile Leu Lys Ile Asn Glu Asp Thr Arg Val
                  85                  90                  95    
 His Gly Leu Ala Leu Gln Ile Ser Glu Asn Leu Phe Ser Asn Lys Val
             100                 105                 110        
 Leu Asn Ala Leu Lys Pro Glu Lys Asp Val Asp Gly Val Thr Asp Ile
         115                 120                 125            
 Asn Leu Gly Lys Leu Val Arg Gly Asp Ala His Glu Cys Phe Val Ser
     130                 135                 140                
 Pro Val Ala Lys Ala Val Ile Glu Leu Leu Glu Lys Ser Gly Val Asn
 145                 150                 155                 160
 Leu Asp Gly Lys Lys Ile Leu Val Val Gly Ala His Gly Ser Leu Glu
                 165                 170                 175    
 Ala Ala Leu Gln Cys Leu Phe Gln Arg Lys Gly Ser Met Thr Met Ser
             180                 185                 190        
 Ile Gln Trp Lys Thr Arg Gln Leu Gln Ser Lys Leu His Glu Ala Asp
         195                 200                 205            
 Ile Val Val Leu Gly Ser Pro Lys Pro Glu Glu Ile Pro Leu Thr Trp
     210                 215                 220                
 Ile Gln Pro Gly Thr Thr Val Leu Asn Cys Ser His Asp Phe Leu Ser
 225                 230                 235                 240
 Gly Lys Val Gly Cys Gly Ser Pro Arg Ile His Phe Gly Gly Leu Ile
                 245                 250                 255    
 Glu Glu Asp Asp Val Ile Leu Leu Ala Ala Ala Leu Arg Ile Gln Asn
             260                 265                 270        
 Met Val Ser Ser Gly Arg Arg Trp Leu Arg Glu Gln Gln His Arg Arg
         275                 280                 285            
 Trp Arg Leu His Cys Leu Lys Leu Gln Pro Leu Ser Pro Val Pro Ser
     290                 295                 300                
 Asp Ile Glu Ile Ser Arg Gly Gln Thr Pro Lys Ala Val Asp Val Leu
 305                 310                 315                 320
 Ala Lys Glu Ile Gly Leu Leu Ala Asp Glu Ile Glu Ile Tyr Gly Lys
                 325                 330                 335    
 Ser Lys Ala Lys Val Arg Leu Ser Val Leu Glu Arg Leu Lys Asp Gln
             340                 345                 350        
 Ala Asp Gly Lys Tyr Val Leu Val Ala Gly Ile Thr Pro Thr Pro Leu
         355                 360                 365            
 Gly Glu Gly Lys Ser Thr Val Thr Ile Gly Leu Val Gln Ala Leu Thr
     370                 375                 380                
 Ala His Leu Asn Val Asn Ser Phe Ala Cys Leu Arg Gln Pro Ser Gln
 385                 390                 395                 400
 Gly Pro Thr Phe Gly Val Lys Gly Gly Ala Ala Gly Gly Gly Tyr Ala
                 405                 410                 415    
 Gln Val Ile Pro Met Glu Glu Phe Asn Leu His Leu Thr Gly Asp Ile
             420                 425                 430        
 His Ala Ile Thr Ala Ala Asn Asn Leu Leu Ala Ala Ala Ile Asp Thr
         435                 440                 445            
 Arg Ile Leu His Glu Asn Thr Gln Thr Asp Lys Ala Leu Tyr Asn Arg
     450                 455                 460                
 Leu Val Pro Leu Val Asn Gly Val Arg Glu Phe Ser Glu Ile Gln Leu
 465                 470                 475                 480
 Ala Arg Leu Lys Lys Leu Gly Ile Asn Lys Thr Asp Pro Ser Thr Leu
                 485                 490                 495    
 Thr Glu Glu Glu Val Ser Lys Phe Ala Arg Leu Asp Ile Asp Pro Ser
             500                 505                 510        
 Thr Ile Thr Trp Gln Arg Val Leu Asp Thr Asn Asp Arg Phe Leu Arg
         515                 520                 525            
 Lys Ile Thr Ile Gly Gln Gly Asn Thr Glu Lys Gly His Tyr Arg Gln
     530                 535                 540                
 Ala Gln Phe Asp Ile Ala Val Ala Ser Glu Ile Met Ala Val Leu Ala
 545                 550                 555                 560
 Leu Thr Asp Ser Leu Ala Asp Met Lys Ala Arg Leu Gly Arg Met Val
                 565                 570                 575    
 Val Ala Ser Asp Lys Ser Gly Gln Pro Val Thr Ala Asp Asp Leu Gly
             580                 585                 590        
 Val Thr Gly Ala Leu Thr Val Leu Met Lys Asp Ala Ile Lys Pro Asn
         595                 600                 605            
 Leu Met Gln Thr Leu Glu Gly Thr Pro Val Phe Val His Ala Gly Pro
     610                 615                 620                
 Phe Ala Asn Ile Ala His Gly Asn Ser Ser Val Leu Ala Asp Lys Ile
 625                 630                 635                 640
 Ala Leu Lys Leu Val Gly Glu Glu Gly Phe Val Val Thr Glu Ala Gly
                 645                 650                 655    
 Phe Gly Ala Asp Ile Gly Met Glu Lys Phe Phe Asn Ile Lys Cys Arg
             660                 665                 670        
 Ala Ser Gly Leu Val Pro Asn Val Val Val Leu Val Ala Thr Val Arg
         675                 680                 685            
 Ala Leu Lys Met His Gly Gly Gly Pro Ser Val Thr Ala Gly Val Pro
     690                 695                 700                
 Leu Lys Lys Glu Tyr Thr Glu Glu Asn Ile Gln Leu Val Ala Asp Gly
 705                 710                 715                 720
 Cys Cys Asn Leu Gln Lys Gln Ile Gln Ile Thr Gln Leu Phe Gly Val
                 725                 730                 735    
 Pro Val Val Val Ala Leu Asn Val Phe Lys Thr Asp Thr Arg Ala Glu
             740                 745                 750        
 Ile Asp Leu Val Cys Glu Leu Ala Lys Arg Ala Gly Ala Phe Asp Ala
         755                 760                 765            
 Val Pro Cys Tyr His Trp Ser Val Gly Gly Lys Gly Ser Val Asp Leu
     770                 775                 780                
 Ala Arg Ala Val Arg Glu Ala Ala Ser Lys Arg Ser Arg Phe Gln Phe
 785                 790                 795                 800
 Leu Tyr Asp Val Gln Val Pro Ile Val Asp Lys Ile Arg Thr Ile Ala
                 805                 810                 815    
 Gln Ala Val Tyr Gly Ala Lys Asp Ile Glu Leu Ser Pro Glu Ala Gln
             820                 825                 830        
 Ala Lys Ile Asp Arg Tyr Thr Gln Gln Gly Phe Gly Asn Leu Pro Ile
         835                 840                 845            
 Cys Met Ala Lys Thr His Leu Ser Leu Ser His Gln Pro Asp Lys Lys
     850                 855                 860                
 Gly Val Pro Arg Asp Phe Ile Leu Pro Ile Ser Asp Val Arg Ala Ser
 865                 870                 875                 880
 Ile Gly Ala Gly Phe Ile Tyr Pro Leu Val Gly Thr Met Ser Thr Met
                 885                 890                 895    
 Pro Gly Leu Pro Thr Arg Pro Cys Phe Tyr Asp Ile Asp Leu Asp Thr
             900                 905                 910        
 Glu Thr Glu Gln Val Lys Gly Leu Phe
         915                 920    



      <210> 2288
      <211> 1257
      <212> PRT
      <213> Homo sapiens


      <400> 2288
 Ile Ile Ser Ile Ile Ser Thr Ser Asn Lys Ile Lys Met Ser Glu Ala
   1               5                  10                  15    
 Pro Arg Phe Phe Val Gly Pro Glu Asp Thr Glu Ile Asn Pro Gly Asn
              20                  25                  30        
 Tyr Arg His Phe Phe His His Ala Asp Glu Asp Asp Glu Glu Glu Asp
          35                  40                  45            
 Asp Ser Pro Pro Glu Arg Gln Ile Val Val Gly Ile Cys Ser Met Ala
      50                  55                  60                
 Lys Lys Ser Gln Ile Pro Asn Pro Met Lys Glu Ile Leu Glu Arg Ile
  65                  70                  75                  80
 Ser Leu Phe Lys Tyr Ile Thr Leu Val Val Phe Glu Glu Glu Val Ile
                  85                  90                  95    
 Leu Asn Glu Pro Val Glu Asn Trp Pro Leu Cys Asp Cys Leu Ile Ser
             100                 105                 110        
 Phe His Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ala Lys
         115                 120                 125            
 Leu Arg Asn Pro Phe Val Ile Asn Asp Leu Asn Met Gln Tyr Leu Ile
     130                 135                 140                
 Gln Asp Arg Arg Glu Val Tyr Ser Ile Leu Gln Ala Glu Gly Ile Leu
 145                 150                 155                 160
 Leu Pro Arg Tyr Ala Ile Leu Asn Arg Asp Pro Asn Asn Pro Lys Glu
                 165                 170                 175    
 Cys Asn Leu Ile Glu Gly Glu Asp His Val Glu Val Asn Gly Glu Val
             180                 185                 190        
 Phe Gln Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn
         195                 200                 205            
 Val Tyr Ile Tyr Tyr Pro Thr Ser Ala Gly Gly Gly Ser Gln Arg Leu
     210                 215                 220                
 Phe Arg Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro Glu Ser Asn
 225                 230                 235                 240
 Val Arg Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met Pro Thr Asp
                 245                 250                 255    
 Gly Thr Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr Ala His Ala
             260                 265                 270        
 Glu Ala Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu Arg Asp Ser
         275                 280                 285            
 Glu Gly Lys Glu Val Arg Tyr Pro Val Ile Leu Asn Ala Arg Glu Lys
     290                 295                 300                
 Leu Ile Ala Trp Lys Val Cys Leu Ala Phe Lys Gln Thr Val Cys Gly
 305                 310                 315                 320
 Phe Asp Leu Leu Arg Ala Asn Gly Gln Ser Tyr Val Cys Asp Val Asn
                 325                 330                 335    
 Gly Phe Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp Asp Cys Ala
             340                 345                 350        
 Lys Ile Leu Gly Asn Ile Val Met Arg Glu Leu Ala Pro Gln Phe His
         355                 360                 365            
 Ile Pro Trp Ser Ile Pro Leu Glu Ala Glu Asp Ile Pro Ile Val Pro
     370                 375                 380                
 Thr Thr Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile Ala Val Ile
 385                 390                 395                 400
 Arg His Gly Asp Arg Thr Pro Lys Gln Lys Met Lys Met Glu Val Arg
                 405                 410                 415    
 His Gln Lys Phe Phe Asp Leu Phe Glu Lys Cys Asp Gly Tyr Lys Ser
             420                 425                 430        
 Gly Lys Leu Lys Leu Lys Lys Pro Lys Gln Leu Gln Glu Val Leu Asp
         435                 440                 445            
 Ile Ala Arg Gln Leu Leu Met Glu Leu Gly Gln Asn Asn Asp Ser Glu
     450                 455                 460                
 Ile Glu Glu Asn Lys Pro Lys Leu Glu Gln Leu Lys Thr Val Leu Glu
 465                 470                 475                 480
 Met Tyr Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln Leu Thr Tyr
                 485                 490                 495    
 Leu Pro His Gly Cys Pro Lys Thr Ser Ser Glu Glu Glu Asp Ser Arg
             500                 505                 510        
 Arg Glu Glu Pro Ser Leu Leu Leu Val Leu Lys Trp Gly Gly Glu Leu
         515                 520                 525            
 Thr Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg Ala Phe Arg
     530                 535                 540                
 Cys Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe Pro Gly Cys
 545                 550                 555                 560
 Gly Leu Leu Arg Leu His Ser Thr Tyr Arg His Asp Leu Lys Ile Tyr
                 565                 570                 575    
 Ala Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala Phe Ala Lys
             580                 585                 590        
 Gly Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu Val Gln Met
         595                 600                 605            
 Val Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp Ser Asp Ser
     610                 615                 620                
 Leu Ser Ser Cys Gln Gln Arg Val Lys Ala Arg Leu His Glu Ile Leu
 625                 630                 635                 640
 Gln Lys Asp Arg Asp Phe Thr Ala Glu Asp Tyr Glu Lys Leu Thr Pro
                 645                 650                 655    
 Ser Gly Ser Ile Ser Leu Ile Lys Ser Met His Leu Ile Lys Asn Pro
             660                 665                 670        
 Val Lys Thr Cys Asp Lys Val Tyr Ser Leu Ile Gln Ser Leu Thr Ser
         675                 680                 685            
 Gln Ile Arg His Arg Met Glu Asp Pro Lys Ser Ser Asp Ile Gln Leu
     690                 695                 700                
 Tyr His Ser Glu Thr Leu Glu Leu Met Leu Arg Arg Trp Ser Lys Leu
 705                 710                 715                 720
 Glu Lys Asp Phe Lys Thr Lys Asn Gly Arg Tyr Asp Ile Ser Lys Ile
                 725                 730                 735    
 Pro Asp Ile Tyr Asp Cys Ile Lys Tyr Asp Val Gln His Asn Gly Phe
             740                 745                 750        
 Leu Glu Ile Arg Lys Thr Gln Trp Glu Leu Tyr Arg Leu Ser Lys Ala
         755                 760                 765            
 Leu Ala Asp Ile Val Ile Pro Gln Glu Tyr Gly Ile Thr Lys Ala Glu
     770                 775                 780                
 Lys Leu Glu Ile Ala Lys Gly Tyr Cys Thr Pro Leu Val Arg Lys Ile
 785                 790                 795                 800
 Arg Ser Asp Leu Gln Arg Thr Gln Asp Asp Asp Thr Val Asn Lys Leu
                 805                 810                 815    
 His Pro Val Tyr Ser Arg Gly Val Leu Ser Pro Glu Arg His Val Arg
             820                 825                 830        
 Thr Arg Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu Leu Ser
         835                 840                 845            
 Ile Leu Arg Tyr Gly Ala Leu Cys Asn Glu Ser Lys Asp Glu Gln Trp
     850                 855                 860                
 Lys Arg Ala Met Asp Tyr Leu Asn Val Val Asn Glu Leu Asn Tyr Met
 865                 870                 875                 880
 Thr Gln Ile Val Ile Met Leu Tyr Glu Asp Pro Asn Lys Asp Leu Ser
                 885                 890                 895    
 Ser Glu Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly Ala Lys
             900                 905                 910        
 Gly Cys Glu Glu Asp Lys Asn Leu Pro Ser Gly Tyr Gly Tyr Arg Pro
         915                 920                 925            
 Ala Ser Arg Glu Asn Glu Gly Arg Arg Pro Phe Lys Ile Asp Asn Asp
     930                 935                 940                
 Asp Glu Pro His Thr Ser Lys Arg Asp Glu Val Asp Arg Ala Val Ile
 945                 950                 955                 960
 Leu Phe Lys Pro Met Val Ser Glu Pro Ile His Ile His Arg Lys Ser
                 965                 970                 975    
 Pro Leu Pro Arg Ser Arg Lys Thr Ala Thr Asn Asp Glu Glu Ser Pro
             980                 985                 990        
 Leu Ser Val Ser Ser Pro Glu Gly Thr Gly Thr Trp Leu His Tyr Thr
         995                1000                1005            
 Ser Gly Val Gly Thr Gly Arg Arg Arg Arg Arg Ser Gly Glu Gln Ile
    1010                1015                1020                
 Thr Ser Ser Pro Val Ser Pro Lys Ser Leu Ala Phe Thr Ser Ser Ile
1025                1030                1035                1040
 Phe Gly Ser Trp Gln Gln Val Val Ser Glu Asn Ala Asn Tyr Leu Arg
                1045                1050                1055    
 Thr Pro Arg Thr Leu Val Glu Gln Lys Gln Asn Pro Thr Val Gly Ser
            1060                1065                1070        
 His Cys Ala Gly Leu Phe Ser Thr Ser Val Leu Gly Gly Ser Ser Ser
        1075                1080                1085            
 Ala Pro Asn Leu Gln Asp Tyr Ala Arg Thr His Arg Lys Lys Leu Thr
    1090                1095                1100                
 Ser Ser Gly Cys Ile Asp Asp Ala Thr Arg Gly Ser Ala Val Lys Arg
1105                1110                1115                1120
 Phe Tyr Ile Ser Phe Ala Arg His Pro Thr Asn Gly Phe Glu Leu Tyr
                1125                1130                1135    
 Ser Met Val Pro Ser Ile Cys Pro Leu Glu Thr Leu His Asn Ala Leu
            1140                1145                1150        
 Ser Leu Lys Gln Val Asp Glu Phe Leu Ala Ser Ile Ala Ser Pro Ser
        1155                1160                1165            
 Ser Asp Val Pro Arg Lys Thr Ala Glu Ile Ser Ser Thr Ala Leu Arg
    1170                1175                1180                
 Ser Ser Pro Ile Met Arg Lys Lys Val Ser Leu Asn Thr Tyr Thr Pro
1185                1190                1195                1200
 Ala Lys Ile Leu Pro Thr Pro Pro Ala Thr Leu Lys Ser Thr Lys Ala
                1205                1210                1215    
 Ser Ser Lys Pro Ala Thr Ser Gly Pro Ser Ser Ala Val Val Pro Asn
            1220                1225                1230        
 Thr Ser Ser Arg Lys Lys Asn Ile Thr Ser Lys Thr Glu Thr His Glu
        1235                1240                1245            
 His Lys Lys Asn Thr Gly Lys Lys Lys
    1250                1255        



      <210> 2289
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 2289
 Phe Ile Asp Asp Glu Leu Ala Thr Glu Trp Ser Leu Thr Met Glu Thr
   1               5                  10                  15    
 Leu Thr Lys Val Leu Ala Arg Asn Leu Tyr Ser Leu Asp Leu Ser Asp
              20                  25                  30        
 Leu Pro Leu Asp Lys Leu Ser Glu Gln Lys Gln Lys Lys His Lys Gly
          35                  40                  45            
 Lys Gly Val Gly His Glu Phe Gln Lys Val Ser Val Asp Lys Ser Phe
      50                  55                  60                
 Ser Arg Gly Trp Ser Arg Asp Gln Pro Gly Gln Ala Pro Met Arg Gln
  65                  70                  75                  80
 Arg Ser Ala Thr Thr Thr Gly Ser Pro Gly Thr Glu Lys Ala Arg Ser
                  85                  90                  95    
 Ile Val Arg Gln Lys Thr Val Asp Ile Asp Asp Ala Gln Ile Leu Pro
             100                 105                 110        
 Arg Ser Thr Arg Val Arg His Phe Ser Gln Ser Glu Glu Thr Gly Asn
         115                 120                 125            
 Glu Val Phe Gly Ala Leu Asn Glu Glu Gln Pro Leu Pro Arg Ser Ser
     130                 135                 140                
 Ser Thr Ser Asp Ile Leu Glu Pro Phe Thr Val Glu Arg Ala Lys Gly
 145                 150                 155                 160
 Ala Val Pro Val Ile Asp Ser Ser Ser Arg His Ala Pro Ser Leu Gln
                 165                 170                 175    
 Ser Phe Thr Glu Ala Ser Ser
             180            



      <210> 2290
      <211> 47
      <212> PRT
      <213> Homo sapiens


      <400> 2290
 Gln Pro Leu Asn His Tyr Phe Ile Cys Ser Ser His Asn Thr Tyr Leu
   1               5                  10                  15    
 Val Gly Asp Gln Leu Cys Gly Gln Ser Ser Val Glu Gly Tyr Ile Arg
              20                  25                  30        
 Cys Ser Gly Gly Arg Glu Gly Val Gln Leu Met Arg Gly Thr Met
          35                  40                  45        



      <210> 2291
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 2291
 Met Asp Leu Cys Gln Lys Asn Glu Thr Asp Leu Glu Asn Ala Glu Asn
   1               5                  10                  15    
 Asn Glu Ile Gln Phe Thr Glu Glu Thr Glu Pro Thr Tyr Thr Cys Pro
              20                  25                  30        
 Asp Gly Lys Ser Glu Lys Asn His Val Tyr Cys Leu Leu Asp Val Ser
          35                  40                  45            
 Asp Ile Thr Leu Glu Gln Asp Glu Lys Ala Lys Glu Phe Ile Ile Gly
      50                  55                  60                
 Thr Gly Trp Glu Glu Ala Pro Pro Gln Arg Ser Ser Pro Ala Val Gly
  65                  70                  75                  80
 Leu Arg Gln Pro Gly Leu Pro Gly Pro His Leu Leu Gly Pro Thr Gly
                  85                  90                  95    
 Gly Arg Lys Gly Leu Gly Gly Thr Arg His Gln Gly Pro Glu Glu Glu
             100                 105                 110        
 Gln Arg Asn Ala Phe Gly Thr Ala Trp Thr Pro Glu Thr His Pro Thr
         115                 120                 125            
 Arg Gly His Thr Gly Arg Thr Glu Ala Ala Val Ala Gly Gly Asp Ala
     130                 135                 140                
 Arg Pro Glu Gly Arg Leu Leu Gly Ser Arg Gln Leu Asn Arg Leu Pro
 145                 150                 155                 160
 Asp Ala Glu Thr Gln
                 165



      <210> 2292
      <211> 318
      <212> PRT
      <213> Homo sapiens


      <400> 2292
 Leu Asp Phe Leu Cys His Arg Asp Met Gly Asp Asn Ile Thr Ser Ile
   1               5                  10                  15    
 Thr Glu Phe Leu Leu Leu Gly Phe Pro Val Gly Pro Arg Ile Gln Met
              20                  25                  30        
 Leu Leu Phe Gly Leu Phe Ser Leu Phe Tyr Val Phe Thr Leu Leu Gly
          35                  40                  45            
 Asn Gly Thr Ile Leu Gly Leu Ile Ser Leu Asp Ser Arg Leu His Ala
      50                  55                  60                
 Pro Met Tyr Phe Phe Leu Ser His Leu Ala Val Val Asp Ile Ala Tyr
  65                  70                  75                  80
 Ala Cys Asn Thr Val Pro Arg Met Leu Val Asn Leu Leu His Pro Ala
                  85                  90                  95    
 Lys Pro Ile Ser Phe Ala Gly Arg Met Met Gln Thr Phe Leu Phe Ser
             100                 105                 110        
 Thr Phe Ala Val Thr Glu Cys Leu Leu Leu Val Val Met Ser Tyr Asp
         115                 120                 125            
 Leu Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Leu Ala Ile Met Thr
     130                 135                 140                
 Trp Arg Val Cys Ile Thr Leu Ala Val Thr Ser Trp Thr Thr Gly Val
 145                 150                 155                 160
 Leu Leu Ser Leu Ile His Leu Val Leu Leu Leu Pro Leu Pro Phe Cys
                 165                 170                 175    
 Arg Pro Gln Lys Ile Tyr His Phe Phe Cys Glu Ile Leu Ala Val Leu
             180                 185                 190        
 Lys Leu Ala Cys Ala Asp Thr His Ile Asn Glu Asn Met Val Leu Ala
         195                 200                 205            
 Gly Ala Ile Ser Gly Leu Val Gly Pro Leu Ser Thr Ile Val Val Ser
     210                 215                 220                
 Tyr Met Cys Ile Leu Cys Ala Ile Leu Gln Ile Gln Ser Arg Glu Val
 225                 230                 235                 240
 Gln Arg Lys Ala Phe Cys Thr Cys Phe Ser His Leu Cys Val Ile Gly
                 245                 250                 255    
 Leu Phe Tyr Gly Thr Ala Ile Ile Met Tyr Val Gly Pro Arg Tyr Gly
             260                 265                 270        
 Asn Pro Lys Glu Gln Lys Lys Tyr Leu Leu Leu Phe His Ser Leu Phe
         275                 280                 285            
 Asn Pro Met Leu Asn Pro Leu Ile Cys Ser Leu Arg Asn Ser Glu Val
     290                 295                 300                
 Lys Asn Thr Leu Lys Arg Val Leu Gly Val Glu Arg Ala Leu
 305                 310                 315            



      <210> 2293
      <211> 383
      <212> PRT
      <213> Homo sapiens


      <400> 2293
 Ile Ser Tyr Cys Pro Lys Phe Pro Asn Arg Asp Gln Arg Asp Lys Asp
   1               5                  10                  15    
 Gly Asp Gly Val Gly Asp Ala Cys Asp Ser Cys Pro Asp Val Ser Asn
              20                  25                  30        
 Pro Asn Gln Ser Asp Val Asp Asn Asp Leu Val Gly Asp Ser Cys Asp
          35                  40                  45            
 Thr Asn Gln Asp Ser Asp Gly Asp Gly His Gln Asp Ser Thr Asp Asn
      50                  55                  60                
 Cys Pro Thr Val Ile Asn Ser Ala Gln Leu Asp Thr Asp Lys Asp Gly
  65                  70                  75                  80
 Ile Gly Asp Glu Cys Asp Asp Asp Asp Asp Asn Asp Gly Ile Pro Asp
                  85                  90                  95    
 Leu Val Pro Pro Gly Pro Asp Asn Cys Arg Leu Val Pro Asn Pro Ala
             100                 105                 110        
 Gln Glu Asp Ser Asn Ser Asp Gly Val Gly Asp Ile Cys Glu Ser Asp
         115                 120                 125            
 Phe Asp Gln Asp Gln Val Ile Asp Arg Ile Asp Val Cys Pro Glu Asn
     130                 135                 140                
 Ala Glu Val Thr Leu Thr Asp Phe Arg Ala Tyr Gln Thr Val Val Leu
 145                 150                 155                 160
 Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp Val Val Leu Asn
                 165                 170                 175    
 Gln Gly Met Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala
             180                 185                 190        
 Val Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu Gly Thr Phe His
         195                 200                 205            
 Val Asn Thr Gln Thr Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr
     210                 215                 220                
 Gln Asp Ser Ser Ser Phe Tyr Val Val Met Trp Lys Gln Thr Glu Gln
 225                 230                 235                 240
 Thr Tyr Trp Gln Ala Thr Pro Phe Arg Ala Val Ala Glu Pro Gly Ile
                 245                 250                 255    
 Gln Leu Lys Ala Val Lys Ser Lys Thr Gly Pro Gly Glu His Leu Arg
             260                 265                 270        
 Asn Ser Leu Trp His Thr Gly Asp Thr Ser Asp Gln Val Arg Leu Leu
         275                 280                 285            
 Trp Lys Asp Ser Arg Asn Val Gly Trp Lys Asp Lys Val Ser Tyr Arg
     290                 295                 300                
 Trp Phe Leu Gln His Arg Pro Gln Val Gly Tyr Ile Arg Val Arg Phe
 305                 310                 315                 320
 Tyr Glu Gly Ser Glu Leu Val Ala Asp Ser Gly Val Thr Ile Asp Thr
                 325                 330                 335    
 Thr Met Arg Gly Gly Arg Leu Gly Val Phe Cys Phe Ser Gln Glu Asn
             340                 345                 350        
 Ile Ile Trp Ser Asn Leu Lys Tyr Arg Cys Asn Asp Thr Ile Pro Glu
         355                 360                 365            
 Asp Phe Gln Glu Phe Gln Thr Gln Asn Phe Asp Arg Phe Asp Asn
     370                 375                 380            



      <210> 2294
      <211> 1277
      <212> PRT
      <213> Homo sapiens


      <400> 2294
 Asp Ala Pro Gly Arg Pro Pro Val Arg Leu Pro Thr Met Glu Leu Glu
   1               5                  10                  15    
 Asp Gly Val Val Tyr Gln Glu Glu Pro Gly Gly Ser Gly Ala Val Met
              20                  25                  30        
 Ser Glu Arg Val Ser Gly Leu Ala Gly Ser Ile Tyr Arg Glu Phe Glu
          35                  40                  45            
 Arg Leu Ile Val Arg Tyr Asp Glu Glu Val Val Lys Glu Leu Ile Pro
      50                  55                  60                
 Leu Val Val Ala Val Leu Glu Asn Leu Asp Ser Val Phe Ala Gln Asp
  65                  70                  75                  80
 Gln Glu His Gln Val Glu Leu Glu Leu Leu Arg Asp Asp Asn Glu Gln
                  85                  90                  95    
 Leu Ile Thr Gln Tyr Glu Arg Glu Lys Ala Leu Arg Lys His Ala Glu
             100                 105                 110        
 Glu Lys Phe Ile Glu Phe Glu Asp Ser Gln Glu Gln Glu Lys Lys Asp
         115                 120                 125            
 Leu Gln Thr Arg Val Glu Ser Leu Glu Ser Gln Thr Arg Gln Leu Glu
     130                 135                 140                
 Leu Lys Ala Lys Asn Tyr Ala Asp Gln Ile Ser Ile Leu Glu Glu Arg
 145                 150                 155                 160
 Glu Ala Glu Leu Lys Lys Glu Tyr Asn Ala Leu His Gln Arg His Thr
                 165                 170                 175    
 Glu Met Ile His Asn Tyr Met Glu His Leu Glu Arg Thr Lys Leu His
             180                 185                 190        
 Gln Leu Ser Gly Ser Asp Gln Leu Glu Ser Thr Ala His Ser Arg Ile
         195                 200                 205            
 Arg Lys Glu Arg Pro Ile Ser Leu Gly Ile Phe Pro Leu Pro Ala Gly
     210                 215                 220                
 Asp Gly Leu Leu Thr Pro Asp Ala Gln Lys Gly Gly Glu Thr Pro Gly
 225                 230                 235                 240
 Ser Glu Gln Trp Lys Phe Gln Glu Leu Ser Gln Pro Arg Ser His Thr
                 245                 250                 255    
 Ser Leu Lys Asp Glu Leu Ser Asp Val Ser Gln Gly Gly Ser Lys Ala
             260                 265                 270        
 Thr Thr Pro Ala Ser Thr Ala Asn Ser Asp Val Ala Thr Ile Pro Thr
         275                 280                 285            
 Asp Thr Pro Leu Lys Glu Glu Asn Glu Gly Phe Val Lys Val Thr Asp
     290                 295                 300                
 Ala Pro Asn Lys Ser Glu Ile Ser Lys His Ile Glu Val Gln Val Ala
 305                 310                 315                 320
 Gln Glu Thr Arg Asn Val Ser Thr Gly Ser Ala Glu Asn Glu Glu Lys
                 325                 330                 335    
 Ser Glu Val Gln Ala Ile Ile Glu Ser Thr Pro Glu Leu Asp Met Asp
             340                 345                 350        
 Lys Asp Leu Ser Gly Tyr Lys Gly Ser Ser Thr Pro Thr Lys Gly Ile
         355                 360                 365            
 Glu Asn Lys Ala Phe Asp Arg Asn Thr Glu Ser Leu Phe Glu Glu Leu
     370                 375                 380                
 Ser Ser Ala Gly Ser Gly Leu Ile Gly Asp Val Asp Glu Gly Ala Asp
 385                 390                 395                 400
 Leu Leu Gly Met Gly Arg Glu Val Glu Asn Leu Ile Leu Glu Asn Thr
                 405                 410                 415    
 Gln Leu Leu Glu Thr Lys Asn Ala Leu Asn Ile Val Lys Asn Asp Leu
             420                 425                 430        
 Ile Ala Lys Val Asp Glu Leu Thr Cys Glu Lys Asp Val Leu Gln Gly
         435                 440                 445            
 Glu Leu Glu Ala Val Lys Gln Ala Lys Leu Lys Leu Glu Glu Lys Asn
     450                 455                 460                
 Arg Glu Leu Glu Glu Glu Leu Arg Lys Ala Arg Ala Glu Ala Glu Asp
 465                 470                 475                 480
 Ala Arg Gln Lys Ala Lys Asp Asp Asp Asp Ser Asp Ile Pro Thr Ala
                 485                 490                 495    
 Gln Arg Lys Arg Phe Thr Arg Val Glu Met Ala Arg Val Leu Met Glu
             500                 505                 510        
 Arg Asn Gln Tyr Lys Glu Arg Leu Met Glu Leu Gln Glu Ala Val Arg
         515                 520                 525            
 Trp Thr Glu Met Ile Arg Ala Ser Arg Glu Asn Pro Ala Met Gln Glu
     530                 535                 540                
 Lys Lys Arg Ser Ser Ile Trp Gln Phe Phe Ser Arg Leu Phe Ser Ser
 545                 550                 555                 560
 Ser Ser Asn Thr Thr Lys Lys Pro Glu Pro Pro Val Asn Leu Lys Tyr
                 565                 570                 575    
 Asn Ala Pro Thr Ser His Val Thr Pro Ser Val Lys Lys Arg Ser Ser
             580                 585                 590        
 Thr Leu Ser Gln Leu Pro Gly Asp Lys Ser Lys Ala Phe Asp Phe Leu
         595                 600                 605            
 Ser Glu Glu Thr Glu Ala Ser Leu Ala Ser Arg Arg Glu Gln Lys Arg
     610                 615                 620                
 Glu Gln Tyr Arg Gln Val Lys Ala His Val Gln Lys Glu Asp Gly Arg
 625                 630                 635                 640
 Val Gln Ala Phe Gly Trp Ser Leu Pro Gln Lys Tyr Lys Gln Val Thr
                 645                 650                 655    
 Asn Gly Gln Gly Glu Asn Lys Met Lys Asn Leu Pro Val Pro Val Tyr
             660                 665                 670        
 Leu Arg Pro Leu Asp Lys Lys Asp Thr Ser Met Lys Leu Trp Cys Ala
         675                 680                 685            
 Val Gly Val Asn Leu Ser Gly Gly Lys Thr Arg Asp Gly Gly Ser Val
     690                 695                 700                
 Val Gly Ala Ser Val Phe Tyr Lys Asp Val Ala Gly Leu Asp Thr Glu
 705                 710                 715                 720
 Gly Ser Lys Gln Arg Ser Ala Ser Gln Ser Ser Leu Asp Lys Leu Asp
                 725                 730                 735    
 Gln Glu Leu Lys Glu Gln Gln Lys Glu Leu Lys Asn Gln Glu Glu Leu
             740                 745                 750        
 Ser Ser Leu Val Trp Ile Cys Thr Ser Thr His Ser Ala Thr Lys Val
         755                 760                 765            
 Leu Ile Ile Asp Ala Val Gln Pro Gly Asn Ile Leu Asp Ser Phe Thr
     770                 775                 780                
 Val Cys Asn Ser His Val Leu Cys Ile Ala Ser Val Pro Gly Ala Arg
 785                 790                 795                 800
 Glu Thr Asp Tyr Pro Ala Gly Glu Asp Leu Ser Glu Ser Gly Gln Val
                 805                 810                 815    
 Asp Lys Ala Ser Leu Cys Gly Ser Met Thr Ser Asn Ser Ser Ala Glu
             820                 825                 830        
 Thr Asp Ser Leu Leu Gly Gly Ile Thr Val Val Gly Cys Ser Ala Glu
         835                 840                 845            
 Gly Val Thr Gly Ala Ala Thr Ser Pro Ser Thr Asn Gly Ala Ser Pro
     850                 855                 860                
 Val Met Asp Lys Pro Pro Glu Met Glu Ala Glu Asn Ser Glu Val Asp
 865                 870                 875                 880
 Glu Asn Val Pro Thr Ala Glu Glu Ala Thr Glu Ala Thr Glu Gly Asn
                 885                 890                 895    
 Ala Gly Ser Ala Glu Asp Thr Val Asp Ile Ser Gln Thr Gly Val Tyr
             900                 905                 910        
 Thr Glu His Val Phe Thr Asp Pro Leu Gly Val Gln Ile Pro Glu Asp
         915                 920                 925            
 Leu Ser Pro Val Tyr Gln Ser Ser Asn Asp Ser Asp Ala Tyr Lys Asp
     930                 935                 940                
 Gln Ile Ser Val Leu Pro Asn Glu Gln Asp Leu Val Arg Glu Glu Ala
 945                 950                 955                 960
 Gln Lys Met Ser Ser Leu Leu Pro Thr Met Trp Leu Gly Ala Gln Asn
                 965                 970                 975    
 Gly Cys Leu Tyr Val His Ser Ser Val Ala Gln Trp Arg Lys Cys Leu
             980                 985                 990        
 His Ser Ile Lys Leu Lys Asp Ser Ile Leu Ser Ile Val His Val Lys
         995                1000                1005            
 Gly Ile Val Leu Val Ala Leu Ala Asp Gly Thr Leu Ala Ile Phe His
    1010                1015                1020                
 Arg Gly Val Asp Gly Gln Trp Asp Leu Ser Asn Tyr His Leu Leu Asp
1025                1030                1035                1040
 Leu Gly Arg Pro His His Ser Ile Arg Cys Met Thr Val Val His Asp
                1045                1050                1055    
 Lys Val Trp Cys Gly Tyr Arg Asn Lys Ile Tyr Val Val Gln Pro Lys
            1060                1065                1070        
 Ala Met Lys Ile Glu Lys Ser Phe Asp Ala His Pro Arg Lys Glu Ser
        1075                1080                1085            
 Gln Val Arg Gln Leu Ala Trp Val Gly Asp Gly Val Trp Val Ser Ile
    1090                1095                1100                
 Arg Leu Asp Ser Thr Leu Arg Leu Tyr His Ala His Thr Tyr Gln His
1105                1110                1115                1120
 Leu Gln Asp Val Asp Ile Glu Pro Tyr Val Ser Lys Met Leu Gly Thr
                1125                1130                1135    
 Gly Lys Leu Gly Phe Ser Phe Val Arg Ile Thr Ala Leu Met Val Ser
            1140                1145                1150        
 Cys Asn Arg Leu Trp Val Gly Thr Gly Asn Gly Val Ile Ile Ser Ile
        1155                1160                1165            
 Pro Leu Thr Glu Thr Val Ile Leu His Gln Gly Arg Leu Leu Gly Leu
    1170                1175                1180                
 Arg Ala Asn Lys Thr Ser Gly Val Pro Gly Asn Arg Pro Gly Ser Val
1185                1190                1195                1200
 Ile Arg Val Tyr Gly Asp Glu Asn Ser Asp Lys Val Thr Pro Gly Thr
                1205                1210                1215    
 Phe Ile Pro Tyr Cys Ser Met Ala His Ala Gln Leu Cys Phe His Gly
            1220                1225                1230        
 His Arg Asp Ala Val Lys Phe Phe Val Ala Val Pro Gly Gln Val Ile
        1235                1240                1245            
 Ser Pro Gln Ser Ser Ser Ser Gly Thr Asp Leu Thr Gly Asp Lys Gly
    1250                1255                1260                
 Arg Gly His Leu His Arg Ser Leu Val Val Arg Arg Pro
1265                1270                1275        



      <210> 2295
      <211> 556
      <212> PRT
      <213> Homo sapiens


      <400> 2295
 Ala Ala Ala Ala Ala Ala Gly Ala Phe Ala Gly Arg Arg Ala Ala Cys
   1               5                  10                  15    
 Gly Ala Val Leu Leu Thr Glu Leu Leu Glu Arg Ala Ala Phe Tyr Gly
              20                  25                  30        
 Ile Thr Ser Asn Leu Val Leu Phe Leu Asn Gly Ala Pro Phe Cys Trp
          35                  40                  45            
 Glu Gly Ala Gln Ala Ser Glu Ala Leu Leu Leu Phe Met Gly Leu Thr
      50                  55                  60                
 Tyr Leu Gly Ser Pro Phe Gly Gly Trp Leu Ala Asp Ala Arg Leu Gly
  65                  70                  75                  80
 Arg Ala Arg Ala Ile Leu Leu Ser Leu Ala Leu Tyr Leu Leu Gly Met
                  85                  90                  95    
 Leu Ala Phe Pro Leu Leu Ala Ala Pro Ala Thr Arg Ala Ala Leu Cys
             100                 105                 110        
 Gly Ser Ala Arg Leu Leu Asn Cys Thr Ala Pro Gly Pro Asp Ala Ala
         115                 120                 125            
 Ala Arg Cys Cys Ser Pro Ala Thr Phe Ala Gly Leu Val Leu Val Gly
     130                 135                 140                
 Leu Gly Val Ala Thr Val Lys Ala Asn Ile Thr Pro Phe Gly Ala Asp
 145                 150                 155                 160
 Gln Val Lys Asp Arg Gly Pro Glu Ala Thr Arg Arg Phe Phe Asn Trp
                 165                 170                 175    
 Phe Tyr Trp Ser Ile Asn Leu Gly Ala Ile Leu Ser Leu Gly Gly Ile
             180                 185                 190        
 Ala Tyr Ile Gln Gln Asn Val Ser Phe Val Thr Gly Tyr Ala Ile Pro
         195                 200                 205            
 Thr Val Cys Val Gly Leu Ala Phe Val Val Phe Leu Cys Gly Gln Ser
     210                 215                 220                
 Val Phe Ile Thr Lys Pro Pro Asp Gly Ser Ala Phe Thr Asp Met Phe
 225                 230                 235                 240
 Lys Ile Leu Thr Tyr Ser Cys Cys Ser Gln Lys Arg Ser Gly Glu Arg
                 245                 250                 255    
 Gln Ser Asn Gly Glu Gly Ile Gly Val Phe Gln Gln Ser Ser Lys Gln
             260                 265                 270        
 Ser Leu Phe Asp Ser Cys Lys Met Ser His Gly Gly Pro Phe Thr Glu
         275                 280                 285            
 Glu Lys Val Glu Asp Val Lys Ala Leu Val Lys Ile Val Pro Val Phe
     290                 295                 300                
 Leu Ala Leu Ile Pro Tyr Trp Thr Val Tyr Phe Gln Met Gln Thr Thr
 305                 310                 315                 320
 Tyr Val Leu Gln Ser Leu His Leu Arg Ile Pro Glu Ile Ser Asn Ile
                 325                 330                 335    
 Thr Thr Thr Pro His Thr Leu Pro Ala Ala Trp Leu Thr Met Phe Asp
             340                 345                 350        
 Ala Val Leu Ile Leu Leu Leu Ile Pro Leu Lys Asp Lys Leu Val Asp
         355                 360                 365            
 Pro Ile Leu Arg Arg His Gly Leu Leu Pro Ser Ser Leu Lys Arg Ile
     370                 375                 380                
 Ala Val Gly Met Phe Phe Val Met Cys Ser Ala Phe Ala Ala Gly Ile
 385                 390                 395                 400
 Leu Glu Ser Lys Arg Leu Asn Leu Val Lys Glu Lys Thr Ile Asn Gln
                 405                 410                 415    
 Thr Ile Gly Asn Val Val Tyr His Ala Ala Asp Leu Ser Leu Trp Trp
             420                 425                 430        
 Gln Val Pro Gln Tyr Leu Leu Ile Gly Ile Ser Glu Ile Phe Ala Ser
         435                 440                 445            
 Ile Ala Gly Leu Glu Phe Ala Tyr Ser Ala Ala Pro Lys Ser Met Gln
     450                 455                 460                
 Ser Ala Ile Met Gly Leu Phe Phe Phe Phe Ser Gly Val Gly Ser Phe
 465                 470                 475                 480
 Val Gly Ser Gly Leu Leu Ala Leu Val Ser Ile Lys Ala Ile Gly Trp
                 485                 490                 495    
 Met Ser Ser His Thr Asp Phe Gly Asn Ile Asn Gly Cys Tyr Leu Asn
             500                 505                 510        
 Tyr Tyr Phe Phe Leu Leu Ala Ala Ile Gln Gly Ala Thr Leu Leu Leu
         515                 520                 525            
 Phe Leu Ile Ile Ser Val Lys Tyr Asp His His Arg Asp His Gln Arg
     530                 535                 540                
 Ser Arg Ala Asn Gly Val Pro Thr Ser Arg Arg Ala
 545                 550                 555    



      <210> 2296
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 2296
 Thr Gln Arg Ala Ala Thr Pro Leu Pro Asn Ser Pro Gln Glu Ala Ala
   1               5                  10                  15    
 Ile Leu Gly Ser Arg Arg Asn Gln Ala Gly Arg Val Arg Glu Lys Val
              20                  25                  30        
 Tyr Arg Ser Leu Pro Gly Pro Ala Phe Leu Gly Glu Ser Trp Lys Arg
          35                  40                  45            
 Leu Ser Val Leu Gln Glu Ser Phe Ser His Leu Thr Pro Arg Gln Ser
      50                  55                  60                
 Gln Met Arg Lys Ser Asp Ile Phe Pro Lys Ser Leu Pro Ser Gln Phe
  65                  70                  75                  80
 Phe Gly Ser Phe Gly Lys Pro Val Ala Cys Val Thr Cys Ala Cys Ser
                  85                  90                  95    
 Leu Gln Leu Leu Lys Phe Ile Pro Glu Lys Ser Asp Ile Asp Leu Leu
             100                 105                 110        
 Val Tyr Arg Ile Asp His Tyr Gln Gln Arg Leu Gln Ala Leu Phe Phe
         115                 120                 125            
 Lys Lys Lys Phe Gln Glu Arg Leu Ala Glu Ala Lys Pro Lys Val Glu
     130                 135                 140                
 Gly Arg Ala Glu Gly Cys Arg Arg Leu Arg Val Glu Ser Tyr Leu Ile
 145                 150                 155                 160
 Met Ile Leu Glu Lys His Phe Pro Asp Ile Leu Asn Met Pro Ser Glu
                 165                 170                 175    
 Leu Gln His Leu Pro Glu Ala Ala Lys Val Lys
             180                 185        



      <210> 2297
      <211> 167
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(167)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2297
 Cys Lys Lys Cys Gln Lys Lys Phe Ser Ser Gly Tyr Gln Leu Ile Leu
   1               5                  10                  15    
 His His Arg Val His Val Ile Glu Arg Pro Tyr Glu Cys Lys Glu Cys
              20                  25                  30        
 Gly Lys Asn Phe Arg Ser Gly Tyr Gln Leu Thr Leu His Gln Arg Phe
          35                  40                  45            
 His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys Asn Phe
      50                  55                  60                
 Arg Ser Gly Tyr Gln Leu Thr Val His Gln Arg Phe His Thr Gly Glu
  65                  70                  75                  80
 Lys Thr Tyr Glu Cys Thr Gln Cys Gly Lys Ala Phe Ile Tyr Ala Ser
                  85                  90                  95    
 His Ile Ala Gln His Glu Arg Ile His Thr Gly Gly Lys Pro Tyr Glu
             100                 105                 110        
 Cys Gln Glu Cys Gly Arg Ala Phe Ser Gln Gly Gly His Leu Arg Ile
         115                 120                 125            
 His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys
     130                 135                 140                
 Gly Lys Thr Phe Ser Thr Arg Ser Xaa Leu Val Glu His Gly Arg Val
 145                 150                 155                 160
 His Thr Asp Glu Lys Pro Tyr
                 165        



      <210> 2298
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 2298
 Pro Ala Pro Ala Ser Gly Phe Thr Gln Thr Trp Gly Asp Ala Cys Asp
   1               5                  10                  15    
 Pro Ala Ala Pro Gln Arg Pro Leu Glu Ala Cys Phe Ser Val Gln Ser
              20                  25                  30        
 Arg Thr Ser Ser Pro Met Glu Pro Pro Ile Pro Gln Ser Ala Pro Leu
          35                  40                  45            
 Thr Pro Asn Ser Val Met Val Gln Pro Leu Leu Asp Ser Arg Met Ser
      50                  55                  60                
 His Ser Arg Leu Gln His Pro Leu Thr Ile Leu Pro Ile Asp Gln Val
  65                  70                  75                  80
 Lys Thr Ser His Val Glu Asn Asp Tyr Ile Asp Asn Pro Ser Leu Ala
                  85                  90                  95    
 Leu Thr Thr Gly Pro Lys Arg Thr Arg Gly Gly Ala Pro Glu Leu Ala
             100                 105                 110        
 Pro Thr Pro Ala
         115    



      <210> 2299
      <211> 740
      <212> PRT
      <213> Homo sapiens


      <400> 2299
 Met Ala Glu Ser Arg Gly Arg Leu Tyr Leu Trp Met Cys Leu Ala Ala
   1               5                  10                  15    
 Ala Leu Ala Ser Phe Leu Met Gly Phe Met Val Gly Trp Phe Ile Lys
              20                  25                  30        
 Pro Leu Lys Glu Thr Thr Thr Ser Val Arg Tyr His Gln Ser Ile Arg
          35                  40                  45            
 Trp Lys Leu Val Ser Glu Met Lys Ala Glu Asn Ile Lys Ser Phe Leu
      50                  55                  60                
 Arg Ser Phe Thr Lys Leu Pro His Leu Ala Gly Thr Glu Gln Asn Phe
  65                  70                  75                  80
 Leu Leu Ala Lys Lys Ile Gln Thr Gln Trp Lys Lys Phe Gly Leu Asp
                  85                  90                  95    
 Ser Ala Lys Leu Val His Tyr Asp Val Leu Leu Ser Tyr Pro Asn Glu
             100                 105                 110        
 Thr Asn Ala Asn Tyr Ile Ser Ile Val Asp Glu His Glu Thr Glu Ile
         115                 120                 125            
 Phe Lys Thr Ser Tyr Leu Glu Pro Pro Pro Asp Gly Tyr Glu Asn Val
     130                 135                 140                
 Thr Asn Ile Val Pro Pro Tyr Asn Ala Phe Ser Ala Gln Gly Met Pro
 145                 150                 155                 160
 Glu Gly Asp Leu Val Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe
                 165                 170                 175    
 Lys Leu Glu Arg Glu Met Gly Ile Asn Cys Thr Gly Lys Ile Val Ile
             180                 185                 190        
 Ala Arg Tyr Gly Lys Ile Phe Arg Gly Asn Lys Val Lys Asn Ala Met
         195                 200                 205            
 Leu Ala Gly Ala Ile Gly Ile Ile Leu Tyr Ser Asp Pro Ala Asp Tyr
     210                 215                 220                
 Phe Ala Pro Glu Val Gln Pro Tyr Pro Lys Gly Trp Asn Leu Pro Gly
 225                 230                 235                 240
 Thr Ala Ala Gln Arg Gly Asn Val Leu Asn Leu Asn Gly Ala Gly Asp
                 245                 250                 255    
 Pro Leu Thr Pro Gly Tyr Pro Ala Lys Glu Tyr Thr Phe Arg Leu Asp
             260                 265                 270        
 Val Glu Glu Gly Val Gly Ile Pro Arg Ile Pro Val His Pro Ile Gly
         275                 280                 285            
 Tyr Asn Asp Ala Glu Ile Leu Leu Arg Tyr Leu Gly Gly Ile Ala Pro
     290                 295                 300                
 Pro Asp Lys Ser Trp Lys Gly Ala Leu Asn Val Ser Tyr Ser Ile Gly
 305                 310                 315                 320
 Pro Gly Phe Thr Gly Ser Asp Ser Phe Arg Lys Val Arg Met His Val
                 325                 330                 335    
 Tyr Asn Ile Asn Lys Ile Thr Arg Ile Tyr Asn Val Val Gly Thr Ile
             340                 345                 350        
 Arg Gly Ser Val Glu Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg
         355                 360                 365            
 Asp Ser Trp Val Phe Gly Ala Ile Asp Pro Thr Ser Gly Val Ala Val
     370                 375                 380                
 Leu Gln Glu Ile Ala Arg Ser Phe Gly Lys Leu Met Ser Lys Gly Trp
 385                 390                 395                 400
 Arg Pro Arg Arg Thr Ile Ile Phe Ala Ser Trp Asp Ala Glu Glu Phe
                 405                 410                 415    
 Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu Glu Asn Val Lys Ile Leu
             420                 425                 430        
 Gln Glu Arg Ser Ile Ala Tyr Ile Asn Ser Asp Ser Ser Ile Glu Gly
         435                 440                 445            
 Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro Leu Leu Tyr Gln Leu Val
     450                 455                 460                
 Tyr Lys Leu Thr Lys Glu Ile Pro Ser Pro Asp Asp Gly Phe Glu Ser
 465                 470                 475                 480
 Lys Phe Leu Tyr Glu Ser Trp Val Glu Lys Asp Pro Ser Pro Glu Asn
                 485                 490                 495    
 Lys Asn Leu Pro Arg Ile Asn Lys Leu Gly Ser Gly Ser Asp Phe Glu
             500                 505                 510        
 Ala Tyr Phe Gln Arg Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr
         515                 520                 525            
 Lys Asn Lys Lys Thr Asp Lys Tyr Ser Ser Tyr Pro Val Tyr His Thr
     530                 535                 540                
 Ile Tyr Glu Thr Phe Glu Leu Val Glu Lys Phe Tyr Asp Pro Thr Phe
 545                 550                 555                 560
 Lys Lys Gln Leu Ser Val Ala Gln Leu Arg Gly Ala Leu Val Tyr Glu
                 565                 570                 575    
 Leu Val Asp Ser Lys Ile Ile Pro Phe Asn Ile Gln Asp Tyr Ala Glu
             580                 585                 590        
 Ala Leu Lys Asn Tyr Ala Ala Ser Ile Tyr Asn Leu Ser Lys Lys His
         595                 600                 605            
 Asp Gln Gln Leu Thr Asp His Gly Val Ser Phe Asp Ser Leu Phe Ser
     610                 615                 620                
 Ala Val Lys Asn Phe Ser Glu Ala Ala Ser Asp Phe His Lys Arg Leu
 625                 630                 635                 640
 Ile Gln Val Asp Leu Asn Asn Pro Ile Ala Val Arg Met Met Asn Asp
                 645                 650                 655    
 Gln Leu Met Leu Leu Glu Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro
             660                 665                 670        
 Gly Lys Leu Phe Tyr Arg His Ile Ile Phe Ala Pro Ser Ser His Asn
         675                 680                 685            
 Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile Tyr Asp Ala Ile Phe Asp
     690                 695                 700                
 Ile Glu Asn Lys Ala Asn Ser Arg Leu Ala Trp Lys Glu Val Lys Lys
 705                 710                 715                 720
 His Ile Ser Ile Ala Ala Phe Thr Ile Gln Ala Ala Ala Gly Thr Leu
                 725                 730                 735    
 Lys Glu Val Leu
             740



      <210> 2300
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 2300
 Pro Gly Val Gly Pro Cys Leu Ser Val Pro Pro Ser Ala Pro Ser Leu
   1               5                  10                  15    
 Val Phe Arg Ser Val Ala Gly Gly Ala Gly Met Ala Glu Arg Gly Leu
              20                  25                  30        
 Glu Pro Ser Pro Ala Ala Val Ala Ala Leu Pro Pro Glu Val Arg Ala
          35                  40                  45            
 Gln Leu Ala Glu Leu Glu Leu Glu Leu Ser Glu Gly Asp Ile Thr Gln
      50                  55                  60                
 Lys Gly Tyr Glu Lys Lys Arg Ser Lys Leu Leu Ser Pro Tyr Ser Pro
  65                  70                  75                  80
 Gln Thr Gln Glu Thr Asp Ser Ala Val Gln Lys Glu Leu Arg Asn Gln
                  85                  90                  95    
 Thr Pro Ala Pro Ser Ala Ala Gln Thr Ser Ala Pro Ser Lys Tyr His
             100                 105                 110        
 Arg Thr Arg Ser Gly Gly Ala Arg Asp Glu Arg Tyr Arg Ser Gly Glu
         115                 120                 125            
 Glu Lys Leu Gln Asn Gly Gln Leu Asn Arg Phe Pro Asn Ser Ser Met
     130                 135                 140                
 Asn Cys Val Ser
 145            



      <210> 2301
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 2301
 Met Ala Leu Gln Leu Trp Ala Leu Thr Leu Leu Gly Leu Leu Gly Ala
   1               5                  10                  15    
 Gly Ala Ser Leu Arg Pro Arg Lys Leu Asp Phe Phe Arg Ser Glu Lys
              20                  25                  30        
 Glu Leu Asn His Leu Ala Val Asp Glu Ala Ser Gly Val Val Tyr Leu
          35                  40                  45            
 Gly Ala Val Asn Ala Leu Tyr Gln Leu Asp Ala Lys Leu Gln Leu Glu
      50                  55                  60                
 Gln Gln Val Ala Thr Gly Pro Val Leu Asp Asn Lys Lys Cys Thr Pro
  65                  70                  75                  80
 Pro Ile Glu Ala Ser Gln Cys His Glu Ala Glu Met Thr Asp Asn Val
                  85                  90                  95    
 Asn Gln Leu Leu Leu Val Asp Pro Pro Arg Lys Arg Leu Val Glu Cys
             100                 105                 110        
 Gly Gln Leu Leu Lys Gly Ile Leu Arg Ser Ala Arg Pro Glu Gln His
         115                 120                 125            
 Leu Pro Pro Pro Val Leu Arg Gly Arg Gln Arg Gly Glu Val Phe Arg
     130                 135                 140                
 Gly Gln Gln
 145        



      <210> 2302
      <211> 59
      <212> PRT
      <213> Homo sapiens


      <400> 2302
 Met Pro Thr Tyr Trp Leu Ala Asn Leu Arg Pro Gly Leu Gln Pro Phe
   1               5                  10                  15    
 Leu Leu His Phe Leu Leu Glu Trp Leu Ala Val Phe Cys Cys Lys Ile
              20                  25                  30        
 Met Val Leu Ala Ala Ala Gly Leu Leu Pro Thr Leu His Met Ala Ser
          35                  40                  45            
 Phe Phe Ser Asn Ala Leu Tyr Asn Cys Phe Tyr
      50                  55                



      <210> 2303
      <211> 383
      <212> PRT
      <213> Homo sapiens


      <400> 2303
 Thr Arg Met Ser Arg His Glu Gly Val Ser Cys Asp Ala Cys Leu Lys
   1               5                  10                  15    
 Gly Asn Phe Arg Gly Arg Arg Tyr Lys Cys Leu Ile Cys Tyr Asp Tyr
              20                  25                  30        
 Asp Leu Cys Ala Ser Cys Tyr Glu Ser Gly Ala Thr Thr Thr Arg His
          35                  40                  45            
 Thr Thr Asp His Pro Met Gln Cys Ile Leu Thr Arg Val Asp Phe Asp
      50                  55                  60                
 Leu Tyr Tyr Gly Gly Glu Ala Phe Ser Val Glu Gln Pro Gln Ser Phe
  65                  70                  75                  80
 Thr Cys Pro Tyr Cys Gly Lys Met Gly Tyr Thr Glu Thr Ser Leu Gln
                  85                  90                  95    
 Glu His Val Thr Ser Glu His Ala Glu Thr Ser Thr Glu Val Ile Cys
             100                 105                 110        
 Pro Ile Cys Ala Ala Leu Pro Gly Gly Asp Pro Asn His Val Thr Asp
         115                 120                 125            
 Asp Phe Ala Ala His Leu Thr Leu Glu His Arg Ala Pro Arg Asp Leu
     130                 135                 140                
 Asp Glu Ser Ser Gly Val Arg His Val Arg Arg Met Phe His Pro Gly
 145                 150                 155                 160
 Arg Gly Leu Gly Gly Pro Arg Ala Arg Arg Ser Asn Met His Phe Thr
                 165                 170                 175    
 Ser Ser Ser Thr Gly Gly Leu Ser Ser Ser Gln Ser Ser Tyr Ser Pro
             180                 185                 190        
 Ser Asn Arg Glu Ala Met Asp Pro Ile Ala Glu Leu Leu Ser Gln Leu
         195                 200                 205            
 Ser Gly Val Arg Arg Ser Ala Gly Gly Gln Leu Asn Ser Ser Gly Pro
     210                 215                 220                
 Ser Ala Ser Gln Leu Gln Gln Leu Gln Met Gln Leu Gln Leu Glu Arg
 225                 230                 235                 240
 Gln His Ala Gln Ala Ala Arg Gln Gln Leu Glu Thr Ala Arg Asn Ala
                 245                 250                 255    
 Thr Arg Arg Thr Asn Thr Ser Ser Val Thr Thr Thr Ile Thr Gln Ser
             260                 265                 270        
 Thr Ala Thr Thr Asn Ile Ala Asn Thr Glu Ser Ser Gln Gln Thr Leu
         275                 280                 285            
 Gln Asn Ser Gln Phe Leu Leu Thr Arg Leu Asn Asp Pro Lys Met Ser
     290                 295                 300                
 Glu Thr Glu Arg Gln Ser Met Glu Ser Glu Arg Ala Asp Arg Ser Leu
 305                 310                 315                 320
 Phe Val Gln Glu Leu Leu Leu Ser Thr Leu Val Arg Glu Glu Ser Ser
                 325                 330                 335    
 Ser Ser Asp Glu Asp Asp Arg Gly Glu Met Ala Asp Phe Gly Ala Met
             340                 345                 350        
 Gly Cys Val Asp Ile Met Pro Leu Asp Val Ala Leu Glu Asn Leu Asn
         355                 360                 365            
 Leu Lys Glu Ser Asn Lys Gly Asn Glu Pro Pro Pro Pro Pro Leu
     370                 375                 380            



      <210> 2304
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 2304
 Pro Leu Thr Glu Asp Gly Ser Pro Gly Pro Pro Pro Glu Gly Phe Lys
   1               5                  10                  15    
 Asp Leu Arg Asn Gln Arg Pro Pro Pro His Thr Gly Pro Trp Arg Gly
              20                  25                  30        
 Pro Gly Pro Ser Gly Pro Pro Arg Ser Gly Gln Val Pro Asp Asn Ser
          35                  40                  45            
 Thr Arg Cys Phe Leu Ser Asp Phe Trp Ser Pro Gln Gly Asp Gln Arg
      50                  55                  60                
 Pro Ser Cys Pro Tyr Thr Gly Ala Arg Pro Arg Gln Gly Ala Ala Gln
  65                  70                  75                  80
 His Leu Arg Cys Pro Ser Arg Arg Arg Arg
                  85                  90



      <210> 2305
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 2305
 Arg Ala Phe Asp Val Arg Arg Lys Lys Ser Leu Arg Pro Cys Cys Pro
   1               5                  10                  15    
 Arg Asp Phe His Ala Gly Cys Leu Thr Val Ser Gly Pro Ser Thr Val
              20                  25                  30        
 Met Gly Ala Val Gly Glu Ser Leu Ser Val Gln Cys Arg Tyr Glu Glu
          35                  40                  45            
 Lys Tyr Lys Thr Phe Asn Lys Tyr Trp Cys Arg Gln Pro Cys Leu Pro
      50                  55                  60                
 Ile Trp His Glu Met Val Glu Thr Gly Gly Ser Glu Gly Val Val Arg
  65                  70                  75                  80
 Ser Asp Gln Val Ile Ile Thr Asp His Pro Gly Asp Leu Thr Phe Thr
                  85                  90                  95    
 Val Thr Leu Glu Asn Leu Thr Ala Asp Asp Ala Gly Lys Tyr Arg Cys
             100                 105                 110        
 Gly Ile Ala Thr Ile Leu Gln Glu Asp Gly Leu Ser Gly Phe Leu Pro
         115                 120                 125            
 Asp Pro Phe Phe Gln Val Gln Val Leu Val Ser Ser Ala Ser Ser Thr
     130                 135                 140                
 Glu Asn Ser Val Lys Thr Pro
 145                 150    



      <210> 2306
      <211> 372
      <212> PRT
      <213> Homo sapiens


      <400> 2306
 Asn Ser Arg Val Asp Asp Phe Val Ala Val Met Ala Pro Arg Thr Leu
   1               5                  10                  15    
 Val Leu Leu Leu Ser Gly Ala Leu Ala Leu Thr Gln Thr Trp Ala Gly
              20                  25                  30        
 Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly Arg
          35                  40                  45            
 Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe
      50                  55                  60                
 Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala
  65                  70                  75                  80
 Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr Arg
                  85                  90                  95    
 Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr Leu
             100                 105                 110        
 Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln Arg
         115                 120                 125            
 Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr
     130                 135                 140                
 His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp
 145                 150                 155                 160
 Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys His
                 165                 170                 175    
 Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu
             180                 185                 190        
 Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu
         195                 200                 205            
 Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His Pro
     210                 215                 220                
 Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr
 225                 230                 235                 240
 Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr
                 245                 250                 255    
 Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe
             260                 265                 270        
 Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr
         275                 280                 285            
 Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg
     290                 295                 300                
 Trp Glu Pro Ser Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala
 305                 310                 315                 320
 Gly Leu Val Leu Phe Gly Ala Val Ile Thr Gly Ala Val Val Ala Ala
                 325                 330                 335    
 Val Met Trp Arg Arg Lys Ser Ser Asp Arg Lys Gly Gly Ser Tyr Ser
             340                 345                 350        
 Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu Thr
         355                 360                 365            
 Ala Cys Lys Val
     370        



      <210> 2307
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 2307
 Asp Ala Trp Val Ala His Ala Ser Gly Glu Leu Pro Pro Gln Thr Thr
   1               5                  10                  15    
 Lys Thr Leu Ala Arg Phe Ile Pro Glu Val Ala Val Ala Tyr Pro Lys
              20                  25                  30        
 Ser Lys Pro Leu Thr Thr Gln Ile Lys Ile Lys Lys Pro Pro Lys Val
          35                  40                  45            
 Thr Met Lys Thr Gly Lys Ser Leu Leu His Leu His Ser Thr Leu Glu
      50                  55                  60                
 Met Phe Ala Ala Arg Trp Arg Ser Lys Ala Pro Met Ser Leu Phe Leu
  65                  70                  75                  80
 Leu Glu Val His Phe Asn Leu Lys Val Gln Tyr Ser Val His Glu Asn
                  85                  90                  95    
 Gln Leu Gln Met Ala Thr Ser Leu Asp Arg Arg Gly Asn Tyr Thr Gly
             100                 105                 110        
 Phe Ile Thr Ser Tyr Leu Glu Glu Ala Tyr Ile Pro Val Val Asn Asp
         115                 120                 125            
 Val Leu Gln Val Gly Leu Pro Leu Pro Asp Phe Leu Ala Met Asn Tyr
     130                 135                 140                
 Asn Leu Ala Glu Leu Asp Ile Val Glu Asn Ala Leu Met Leu Asp Leu
 145                 150                 155                 160
 Lys Leu Gly
            



      <210> 2308
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 2308
 Asp Ala Trp Val Ala His Ala Ser Gly Glu Leu Pro Pro Gln Thr Thr
   1               5                  10                  15    
 Lys Thr Leu Ala Arg Phe Ile Pro Glu Val Ala Val Ala Tyr Pro Lys
              20                  25                  30        
 Ser Lys Pro Leu Thr Thr Gln Ile Lys Ile Lys Lys Pro Pro Lys Val
          35                  40                  45            
 Thr Met Lys Thr Gly Lys Ser Leu Leu His Leu His Ser Thr Leu Glu
      50                  55                  60                
 Met Phe Ala Ala Arg Trp Arg Ser Lys Ala Pro Met Ser Leu Phe Leu
  65                  70                  75                  80
 Leu Glu Val His Phe Asn Leu Lys Val Gln Tyr Ser Val His Glu Asn
                  85                  90                  95    
 Gln Leu Gln Met Ala Thr Ser Leu Asp Arg Arg Gly Asn Tyr Thr Gly
             100                 105                 110        
 Phe Ile Thr Ser Tyr Leu Glu Glu Ala Tyr Ile Pro Val Val Asn Asp
         115                 120                 125            
 Val Leu Gln Val Gly Leu Pro Leu Pro Asp Phe Leu Ala Met Asn Tyr
     130                 135                 140                
 Asn Leu Ala Glu Leu Asp Ile Val Glu Asn Ala Leu Met Leu Asp Leu
 145                 150                 155                 160
 Lys Leu Gly
            



      <210> 2309
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 2309
 Asp Ala Trp Val Ala His Ala Ser Gly Glu Leu Pro Pro Gln Thr Thr
   1               5                  10                  15    
 Lys Thr Leu Ala Arg Phe Ile Pro Glu Val Ala Val Ala Tyr Pro Lys
              20                  25                  30        
 Ser Lys Pro Leu Thr Thr Gln Ile Lys Ile Lys Lys Pro Pro Lys Val
          35                  40                  45            
 Thr Met Lys Thr Gly Lys Ser Leu Leu His Leu His Ser Thr Leu Glu
      50                  55                  60                
 Met Phe Ala Ala Arg Trp Arg Ser Lys Ala Pro Met Ser Leu Phe Leu
  65                  70                  75                  80
 Leu Glu Val His Phe Asn Leu Lys Val Gln Tyr Ser Val His Glu Asn
                  85                  90                  95    
 Gln Leu Gln Met Ala Thr Ser Leu Asp Arg Arg Gly Asn Tyr Thr Gly
             100                 105                 110        
 Phe Ile Thr Ser Tyr Leu Glu Glu Ala Tyr Ile Pro Val Val Asn Asp
         115                 120                 125            
 Val Leu Gln Val Gly Leu Pro Leu Pro Asp Phe Leu Ala Met Asn Tyr
     130                 135                 140                
 Asn Leu Ala Glu Leu Asp Ile Val Glu Asn Ala Leu Met Leu Asp Leu
 145                 150                 155                 160
 Lys Leu Gly
            



      <210> 2310
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 2310
 Asp Ala Trp Val Ala His Ala Ser Gly Glu Leu Pro Pro Gln Thr Thr
   1               5                  10                  15    
 Lys Thr Leu Ala Arg Phe Ile Pro Glu Val Ala Val Ala Tyr Pro Lys
              20                  25                  30        
 Ser Lys Pro Leu Thr Thr Gln Ile Lys Ile Lys Lys Pro Pro Lys Val
          35                  40                  45            
 Thr Met Lys Thr Gly Lys Ser Leu Leu His Leu His Ser Thr Leu Glu
      50                  55                  60                
 Met Phe Ala Ala Arg Trp Arg Ser Lys Ala Pro Met Ser Leu Phe Leu
  65                  70                  75                  80
 Leu Glu Val His Phe Asn Leu Lys Val Gln Tyr Ser Val His Glu Asn
                  85                  90                  95    
 Gln Leu Gln Met Ala Thr Ser Leu Asp Arg Arg Gly Asn Tyr Thr Gly
             100                 105                 110        
 Phe Ile Thr Ser Tyr Leu Glu Glu Ala Tyr Ile Pro Val Val Asn Asp
         115                 120                 125            
 Val Leu Gln Val Gly Leu Pro Leu Pro Asp Phe Leu Ala Met Asn Tyr
     130                 135                 140                
 Asn Leu Ala Glu Leu Asp Ile Val Glu Asn Ala Leu Met Leu Asp Leu
 145                 150                 155                 160
 Lys Leu Gly
            



      <210> 2311
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 2311
 Ala Pro Arg Ala Ala Pro Arg Leu Thr Met Val Ser Arg Met Val Ser
   1               5                  10                  15    
 Thr Met Leu Ser Gly Leu Leu Phe Trp Leu Ala Ser Gly Trp Thr Pro
              20                  25                  30        
 Ala Phe Ala Tyr Ser Pro Arg Thr Pro Asp Arg Val Ser Glu Ala Asp
          35                  40                  45            
 Ile Gln Arg Leu Leu His Gly Val Met Glu Gln Leu Gly Ile Ala Arg
      50                  55                  60                
 Pro Arg Val Glu Tyr Pro Ala His Gln Ala Met Asn Leu Val Gly Pro
  65                  70                  75                  80
 Gln Ser Ile Glu Gly Gly Ala His Glu Gly Leu Gln His Leu Gly Pro
                  85                  90                  95    
 Phe Gly Asn Ile Pro Asn Ile Val Ala Glu Leu Thr Gly Asp Asn Ile
             100                 105                 110        
 Pro Lys Asp Phe Ser Glu Asp Gln Gly Tyr Pro Asp Pro Pro Asn Pro
         115                 120                 125            
 Cys Pro Val Gly Lys Thr Ala Asp Asp Gly Cys Leu Glu Asn Thr Pro
     130                 135                 140                
 Asp Thr Ala Glu Phe Ser Arg Glu Phe Gln Leu His Gln His Leu Phe
 145                 150                 155                 160
 Asp Pro Glu His Asp Tyr Pro Gly Leu Gly Lys Trp Asn Lys Lys Leu
                 165                 170                 175    
 Leu Tyr Gly Lys Met Lys Gly Gly Glu Arg Arg Lys Arg Arg Ser Val
             180                 185                 190        
 Asn Pro Tyr Leu Gln Gly Gln Arg Leu Asp Asn Val Val Ala Lys Lys
         195                 200                 205            
 Ser Val Pro His Phe Ser Asp Glu Asp Lys Asp Pro Glu
     210                 215                 220    



      <210> 2312
      <211> 201
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(201)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2312
 Pro Ser Ile Arg Lys His Gly Thr His Pro Phe Pro Pro Thr Xaa Ser
   1               5                  10                  15    
 Ser Pro Ser Gly Ser Cys Ser His Cys Ile Ala His Ser Gln Cys Arg
              20                  25                  30        
 Gln Ser Pro Pro His Ala Ser Cys Xaa Arg Gly Ser Arg Trp Gly Xaa
          35                  40                  45            
 Ser Gly Arg Ala Gly Trp Pro Ala Pro Gly Cys Arg Xaa Ala Ala Pro
      50                  55                  60                
 Gly Leu Ala Gly Ser Ala His Pro Arg Pro Pro Pro Ser Asn Pro Arg
  65                  70                  75                  80
 Cys Pro Pro Pro Asp Ala Gly Pro Pro Gly Ser Gly Asp Pro Gly Leu
                  85                  90                  95    
 Ala Ala Pro Glu Pro Ser Asn His Gly Arg Gln His Thr Ala Ala Ala
             100                 105                 110        
 Ala Ala Ala Gly Glu Ser Gln Arg His Gly Arg Pro Gly Leu Ala Ala
         115                 120                 125            
 Xaa Gln Pro Pro Leu Asp Thr Gly Pro Ala Ala Arg Gly Ser Pro Pro
     130                 135                 140                
 Ala Pro Pro Gly Ala Arg Pro Arg Gly Gly Gly Arg Gln His Arg Pro
 145                 150                 155                 160
 Gln Gly Leu Pro Gln Ala Gln Pro Gln Xaa Ala Pro Gly Val Arg Ala
                 165                 170                 175    
 Ala Pro Arg Ala Ala Ala Pro Pro Gly His Ala Gly Pro Asp Gln Ala
             180                 185                 190        
 Pro Glu Lys Ala Ala Arg Thr Arg Gly
         195                 200    



      <210> 2313
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 2313
 Pro Arg Gly Gln Met Ala Ser Thr Gly Leu Glu Leu Leu Gly Met Thr
   1               5                  10                  15    
 Leu Ala Val Leu Gly Trp Leu Gly Thr Leu Val Ser Cys Ala Leu Pro
              20                  25                  30        
 Leu Trp Lys Val Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln
          35                  40                  45            
 Val Val Trp Glu Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly
      50                  55                  60                
 Gln Met Gln Cys Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp
  65                  70                  75                  80
 Leu Gln Ala Ala Arg Ala Leu Cys Val Ile Ala Leu Leu Leu Ala Leu
                  85                  90                  95    
 Leu Gly Leu Leu Val Ala Ile Thr Gly Ala Gln Cys Thr Thr Cys Val
             100                 105                 110        
 Glu Asp Glu Gly Ala Lys Ala Arg Ile Val Leu Thr Ala Gly Val Ile
         115                 120                 125            
 Leu Leu Leu Ala Gly Ile Leu Val Leu Ile Pro Val Cys Trp Thr Ala
     130                 135                 140                
 His Ala Ile Ile Gln Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Leu
 145                 150                 155                 160
 Lys Arg Glu Leu Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ala Ala
                 165                 170                 175    
 Leu Leu Met Leu Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Pro Pro
             180                 185                 190        
 Gln Val Glu Arg Pro Arg Gly Pro Arg Leu Gly Tyr Ser Ile Pro Ser
         195                 200                 205            
 Arg Ser Gly Ala Ser Gly Leu Asp Lys Arg Asp Tyr Val
     210                 215                 220    



      <210> 2314
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 2314
 Phe Val Ala Asn Met Leu Cys Gly Leu Ser Arg Glu Thr Pro Gly Glu
   1               5                  10                  15    
 Ala Asp Asp Gly Pro Tyr Ser Lys Gly Gly Lys Asp Ala Gly Gly Ala
              20                  25                  30        
 Asp Val Cys Leu Ala Cys Arg Arg Gln Ser Ile Pro Glu Glu Phe Arg
          35                  40                  45            
 Gly Ile Thr Val Val Glu Leu Ile Lys Lys Glu Gly Ser Thr Leu Gly
      50                  55                  60                
 Leu Thr Ile Ser Gly Gly Thr Asp Lys Asp Gly Lys Pro Arg Val Ser
  65                  70                  75                  80
 Asn Leu Arg Pro Gly Gly Leu Ala Ala Arg Ser Asp Leu Leu Asn Ile
                  85                  90                  95    
 Gly Asp Tyr Ile Arg Ser Val Asn Gly Ile His Leu Thr Arg Leu Arg
             100                 105                 110        
 His Asp Glu Ile Ile Thr Leu Leu Lys Asn Val Gly Glu Arg Val Val
         115                 120                 125            
 Leu Glu Ala Pro Glu Asn Asn Pro Arg Ile Ile Ser Lys Thr Val Asp
     130                 135                 140                
 Val Ser Leu Tyr Lys Glu Gly Asn Ser Phe Gly Phe Val Leu Arg Gly
 145                 150                 155                 160
 Gln
    



      <210> 2315
      <211> 558
      <212> PRT
      <213> Homo sapiens


      <400> 2315
 Gly Leu Ser Arg Met Ser Thr Glu Thr Glu Leu Gln Val Ala Val Lys
   1               5                  10                  15    
 Thr Ser Ala Lys Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu
              20                  25                  30        
 Ala Thr Leu Ile Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala
          35                  40                  45            
 Lys Leu Ile Gly Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu
      50                  55                  60                
 Cys Gln Asp Ser Met Met Lys Leu Lys Gly Val Val Ala Gly Ala Arg
  65                  70                  75                  80
 Ser Lys Gly Glu His Lys Gln Lys Ile Phe Leu Thr Ile Ser Phe Gly
                  85                  90                  95    
 Gly Ile Lys Ile Phe Asp Glu Lys Thr Gly Ala Leu Gln His His His
             100                 105                 110        
 Ala Val His Glu Ile Ser Tyr Ile Ala Lys Asp Ile Thr Asp His Arg
         115                 120                 125            
 Ala Phe Gly Tyr Val Cys Gly Lys Glu Gly Asn His Arg Phe Val Ala
     130                 135                 140                
 Ile Lys Thr Ala Gln Ala Ala Glu Pro Val Ile Leu Asp Leu Arg Asp
 145                 150                 155                 160
 Leu Phe Gln Leu Ile Tyr Glu Leu Lys Gln Arg Glu Glu Leu Glu Lys
                 165                 170                 175    
 Lys Ala Gln Lys Asp Lys Gln Cys Glu Gln Ala Val Tyr Gln Thr Ile
             180                 185                 190        
 Leu Glu Glu Asp Val Glu Asp Pro Val Tyr Gln Tyr Ile Val Phe Glu
         195                 200                 205            
 Ala Gly His Glu Pro Ile Arg Asp Pro Glu Thr Glu Glu Asn Ile Tyr
     210                 215                 220                
 Gln Val Pro Thr Ser Gln Lys Lys Glu Gly Val Tyr Asp Val Pro Lys
 225                 230                 235                 240
 Ser Gln Pro Val Ser Ala Val Thr Gln Leu Glu Leu Phe Gly Asp Met
                 245                 250                 255    
 Ser Thr Pro Pro Asp Ile Thr Ser Pro Pro Thr Pro Ala Thr Pro Gly
             260                 265                 270        
 Asp Ala Phe Ile Pro Ser Ser Ser Gln Thr Leu Pro Ala Ser Ala Asp
         275                 280                 285            
 Val Phe Ser Ser Val Pro Phe Gly Thr Ala Ala Val Pro Ser Gly Tyr
     290                 295                 300                
 Val Ala Met Gly Ala Val Leu Pro Ser Phe Trp Gly Gln Gln Pro Leu
 305                 310                 315                 320
 Val Gln Gln Gln Met Val Met Gly Ala Gln Pro Pro Val Ala Gln Val
                 325                 330                 335    
 Met Pro Gly Ala Gln Pro Ile Ala Trp Gly Gln Pro Gly Leu Phe Pro
             340                 345                 350        
 Ala Thr Gln Gln Pro Trp Pro Thr Val Ala Gly Gln Phe Pro Pro Ala
         355                 360                 365            
 Ala Phe Met Pro Thr Gln Thr Val Met Pro Leu Pro Ala Ala Met Phe
     370                 375                 380                
 Gln Gly Pro Leu Thr Pro Leu Ala Thr Val Pro Gly Thr Ser Asp Ser
 385                 390                 395                 400
 Thr Arg Ser Ser Pro Gln Thr Asp Lys Pro Arg Gln Lys Met Gly Lys
                 405                 410                 415    
 Glu Thr Phe Lys Asp Phe Gln Met Ala Gln Pro Pro Pro Val Pro Ser
             420                 425                 430        
 Arg Lys Pro Asp Gln Pro Ser Leu Thr Cys Thr Ser Glu Ala Phe Ser
         435                 440                 445            
 Ser Tyr Phe Asn Lys Val Gly Val Ala Gln Asp Thr Asp Asp Cys Asp
     450                 455                 460                
 Asp Phe Asp Ile Ser Gln Leu Asn Leu Thr Pro Val Thr Ser Thr Thr
 465                 470                 475                 480
 Pro Ser Thr Asn Ser Pro Pro Thr Pro Ala Pro Arg Gln Ser Ser Pro
                 485                 490                 495    
 Ser Lys Ser Ser Ala Ser His Ala Ser Asp Pro Thr Thr Asp Asp Ile
             500                 505                 510        
 Phe Glu Glu Gly Phe Glu Ser Pro Ser Lys Ser Glu Glu Gln Glu Ala
         515                 520                 525            
 Pro Asp Gly Ser Gln Ala Ser Ser Asn Ser Asp Pro Phe Gly Glu Pro
     530                 535                 540                
 Ser Gly Glu Pro Ser Gly Asp Asn Ile Ser Pro Gln Gly Arg
 545                 550                 555            



      <210> 2316
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 2316
 Val Asn Val Leu Asn Gln Glu Ile Glu Ala Phe Ser Leu Ser Glu Asp
   1               5                  10                  15    
 Thr Ser Ser Gly Leu Pro Glu Asp Arg Val Val Ser Val Ser Phe Arg
              20                  25                  30        
 Val Leu Tyr Pro Ile Val Ile Thr Ser Leu Gly Val Phe Tyr Asp Ala
          35                  40                  45            
 Asn Asp Val Gly Phe Gln Arg Asn Ile Thr Val Lys Leu Tyr Gln Ala
      50                  55                  60                
 Glu Gln Glu Glu Ala Leu Phe Ile Ala Arg Phe Ser Pro Pro Ser Cys
  65                  70                  75                  80
 Gly Val Gln Val Asn Lys Leu Trp Tyr Lys Pro Val Glu Gln Phe Ile
                  85                  90                  95    
 Leu Pro Glu
            



      <210> 2317
      <211> 368
      <212> PRT
      <213> Homo sapiens


      <400> 2317
 Thr Ala Ala Ala Pro Val Ala Pro Gly Thr Met Asp Asp Ala Thr Val
   1               5                  10                  15    
 Leu Arg Lys Lys Gly Tyr Ile Val Gly Ile Asn Leu Gly Lys Gly Ser
              20                  25                  30        
 Tyr Ala Lys Val Lys Ser Ala Tyr Ser Glu Arg Leu Lys Phe Asn Val
          35                  40                  45            
 Ala Val Lys Ile Ile Ala Arg Lys Lys Thr Pro Thr Asp Phe Val Glu
      50                  55                  60                
 Arg Phe Leu Pro Arg Glu Met Asp Ile Leu Ala Thr Val Asn His Gly
  65                  70                  75                  80
 Ser Ile Ile Lys Thr Tyr Glu Ile Phe Glu Thr Ser Asp Gly Arg Ile
                  85                  90                  95    
 Tyr Ile Ile Met Glu Leu Gly Val Gln Gly Asp Leu Leu Glu Phe Ile
             100                 105                 110        
 Lys Cys Gln Gly Ala Leu His Glu Asp Val Ala Arg Lys Met Phe Arg
         115                 120                 125            
 Gln Leu Ser Ser Ala Val Lys Tyr Cys His Asp Leu Asp Ile Val His
     130                 135                 140                
 Arg Asp Leu Lys Cys Glu Asn Leu Leu Leu Asp Lys Asp Phe Asn Ile
 145                 150                 155                 160
 Lys Leu Ser Asp Phe Gly Phe Ser Lys Arg Cys Leu Arg Asp Ser Asn
                 165                 170                 175    
 Gly Arg Ile Ile Leu Ser Lys Thr Phe Cys Gly Ser Ala Ala Tyr Ala
             180                 185                 190        
 Ala Pro Glu Val Leu Gln Ser Ile Pro Tyr Gln Pro Lys Val Tyr Asp
         195                 200                 205            
 Ile Trp Ser Leu Gly Val Ile Leu Tyr Ile Met Val Cys Gly Ser Met
     210                 215                 220                
 Pro Tyr Asp Asp Ser Asp Ile Arg Lys Met Leu Arg Ile Gln Lys Glu
 225                 230                 235                 240
 His Arg Val Asp Phe Pro Arg Ser Lys Asn Leu Thr Cys Glu Cys Lys
                 245                 250                 255    
 Asp Leu Ile Tyr Arg Met Leu Gln Pro Asp Val Ser Lys Arg Leu His
             260                 265                 270        
 Ile Asp Glu Ile Leu Ser His Ser Trp Leu Gln Pro Pro Lys Pro Lys
         275                 280                 285            
 Ala Thr Ser Ser Ala Ser Phe Lys Arg Glu Gly Glu Gly Lys Tyr Arg
     290                 295                 300                
 Ala Glu Cys Lys Leu Asp Thr Lys Thr Gly Leu Arg Pro Asp His Arg
 305                 310                 315                 320
 Pro Asp His Lys Leu Gly Ala Lys Thr Gln His Arg Leu Leu Val Val
                 325                 330                 335    
 Pro Glu Asn Glu Asn Arg Met Glu Asp Arg Leu Ala Glu Thr Ser Arg
             340                 345                 350        
 Ala Lys Asp His His Ile Ser Gly Ala Glu Val Gly Lys Ala Ser Thr
         355                 360                 365            





      <210> 2318
      <211> 210
      <212> PRT
      <213> Homo sapiens


      <400> 2318
 Thr Arg Tyr Ala Thr Pro Leu Ala Pro Gly Pro Gly His Pro Phe Ser
   1               5                  10                  15    
 Cys Ser Arg Arg Met Ala Thr His His Thr Leu Trp Met Gly Leu Ala
              20                  25                  30        
 Leu Leu Gly Val Leu Gly Asp Leu Gln Ala Ala Pro Glu Ala Gln Val
          35                  40                  45            
 Ser Val Gln Pro Asn Phe Gln Gln Asp Lys Phe Leu Gly Arg Trp Phe
      50                  55                  60                
 Ser Ala Gly Leu Ala Ser Asn Ser Ser Trp Leu Arg Glu Lys Lys Ala
  65                  70                  75                  80
 Ala Leu Ser Met Cys Lys Ser Val Val Ala Pro Ala Thr Asp Gly Gly
                  85                  90                  95    
 Leu Asn Leu Thr Ser Thr Phe Leu Arg Lys Asn Gln Cys Glu Thr Arg
             100                 105                 110        
 Thr Met Leu Leu Gln Pro Ala Gly Ser Leu Gly Ser Tyr Ser Tyr Arg
         115                 120                 125            
 Ser Pro His Trp Gly Ser Thr Tyr Ser Val Ser Val Val Glu Thr Asp
     130                 135                 140                
 Tyr Asp Gln Tyr Ala Leu Leu Tyr Ser Gln Gly Ser Lys Gly Pro Gly
 145                 150                 155                 160
 Glu Asp Phe Arg Met Ala Thr Leu Tyr Ser Arg Thr Gln Thr Pro Arg
                 165                 170                 175    
 Ala Glu Leu Lys Glu Lys Phe Thr Ala Phe Cys Lys Ala Gln Gly Phe
             180                 185                 190        
 Thr Glu Asp Thr Ile Val Phe Leu Pro Gln Thr Asp Lys Cys Met Thr
         195                 200                 205            
 Glu Gln
     210



      <210> 2319
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 2319
 Ala Ile His Val Arg Cys Leu Leu Ser Pro Gly His Thr Ala Gly His
   1               5                  10                  15    
 Met Ser Tyr Phe Leu Trp Glu Asp Asp Cys Pro Asp Pro Pro Ala Leu
              20                  25                  30        
 Phe Ser Gly Asp Ala Leu Ser Val Ala Gly Cys Gly Ser Cys Leu Glu
          35                  40                  45            
 Gly Ser Ala Gln Gln Met Tyr Gln Ser Leu Ala Glu Leu Gly Thr Leu
      50                  55                  60                
 Pro Pro Glu Thr Lys Val Phe Cys Gly His Glu His Thr Leu Ser Asn
  65                  70                  75                  80
 Leu Glu Phe Ala Gln Lys Val Glu Pro Cys Asn Asp His Lys Arg Asp
                  85                  90                  95    
 Glu Asp Asp Val Pro Thr Val Pro Ser Thr Leu Gly Glu Glu Arg Leu
             100                 105                 110        
 Tyr Asn Pro Phe Leu Arg Val Ala Glu Glu Pro Val Arg Lys Phe Thr
         115                 120                 125            
 Gly Lys Ala
     130    



      <210> 2320
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 2320
 Leu Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr
   1               5                  10                  15    
 Ala Leu Ala Leu Leu Asp His Pro Ser Glu Tyr Ala Ala Arg Gln Leu
              20                  25                  30        
 Gln Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu
          35                  40                  45            
 Phe Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala
      50                  55                  60                
 Tyr Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asn Val Lys Gly Asp
  65                  70                  75                  80
 Thr Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn
                  85                  90                  95    
 Arg Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala
             100                 105                 110        
 Lys Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu
         115                 120                 125            
 Ala Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala
     130                 135                 140                
 Thr Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala
 145                 150                 155                 160
 Ile Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu
                 165                 170                 175    
 Val Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr
             180                 185                 190        
 Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile
         195                 200                 205            
 Ile Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe
     210                 215                 220                
 Gln Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr
 225                 230                 235                 240
 Ser Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His
                 245                 250            



      <210> 2321
      <211> 443
      <212> PRT
      <213> Homo sapiens


      <400> 2321
 Gln His Ser Ser Arg Ala Gly Ile Ser Ser Val Ala Met Pro Trp Ala
   1               5                  10                  15    
 Pro Leu Gly His Ser Gly Ser His Gln Leu Cys Val Thr Phe Ser Ser
              20                  25                  30        
 Leu His Cys Leu Thr Arg Arg Asn Met His Gln Met Thr Asp Gly Leu
          35                  40                  45            
 Asp Lys Pro Gly Gln Ile Arg Trp Pro Leu Ala Ile Thr Leu Ala Ile
      50                  55                  60                
 Ala Trp Ile Leu Val Tyr Phe Cys Ile Trp Lys Gly Val Gly Trp Thr
  65                  70                  75                  80
 Gly Lys Val Val Tyr Phe Ser Ala Thr Tyr Pro Tyr Ile Met Leu Ile
                  85                  90                  95    
 Ile Leu Phe Phe Arg Gly Val Thr Leu Pro Gly Ala Lys Glu Gly Ile
             100                 105                 110        
 Leu Phe Tyr Ile Thr Pro Asn Phe Arg Lys Leu Ser Asp Ser Glu Val
         115                 120                 125            
 Trp Leu Asp Ala Ala Thr Gln Ile Phe Phe Ser Tyr Gly Leu Gly Leu
     130                 135                 140                
 Gly Ser Leu Ile Ala Leu Gly Ser Tyr Asn Ser Phe His Asn Asn Val
 145                 150                 155                 160
 Tyr Arg Asp Ser Ile Ile Val Cys Cys Ile Asn Ser Cys Thr Ser Met
                 165                 170                 175    
 Phe Ala Gly Phe Val Ile Phe Ser Ile Val Gly Phe Met Ala His Val
             180                 185                 190        
 Thr Lys Arg Ser Ile Ala Asp Val Ala Ala Ser Gly Pro Gly Leu Ala
         195                 200                 205            
 Phe Leu Ala Tyr Pro Glu Ala Val Thr Gln Leu Pro Ile Ser Pro Leu
     210                 215                 220                
 Trp Ala Ile Leu Phe Phe Ser Met Leu Leu Met Leu Gly Ile Asp Ser
 225                 230                 235                 240
 Gln Phe Cys Thr Val Glu Gly Phe Ile Thr Ala Leu Val Asp Glu Tyr
                 245                 250                 255    
 Pro Arg Leu Leu Arg Asn Arg Arg Glu Leu Phe Ile Ala Ala Val Cys
             260                 265                 270        
 Ile Ile Ser Tyr Leu Ile Gly Leu Ser Asn Ile Thr Gln Gly Gly Ile
         275                 280                 285            
 Tyr Val Phe Lys Leu Phe Asp Tyr Tyr Ser Ala Ser Gly Met Ser Leu
     290                 295                 300                
 Leu Phe Leu Val Phe Phe Glu Cys Val Ser Ile Ser Trp Phe Tyr Gly
 305                 310                 315                 320
 Val Asn Arg Phe Tyr Asp Asn Ile Gln Glu Met Val Gly Ser Arg Pro
                 325                 330                 335    
 Cys Ile Trp Trp Lys Leu Cys Trp Ser Phe Phe Thr Pro Ile Ile Val
             340                 345                 350        
 Ala Gly Val Phe Ile Phe Ser Ala Val Gln Met Thr Pro Leu Thr Met
         355                 360                 365            
 Gly Asn Tyr Val Phe Pro Lys Trp Gly Gln Gly Val Gly Trp Leu Met
     370                 375                 380                
 Ala Leu Ser Ser Met Val Leu Ile Pro Gly Tyr Met Ala Tyr Met Phe
 385                 390                 395                 400
 Leu Thr Leu Lys Gly Ser Leu Lys Gln Arg Ile Gln Val Met Val Gln
                 405                 410                 415    
 Pro Ser Glu Asp Ile Val Arg Pro Glu Asn Gly Pro Glu Gln Pro Gln
             420                 425                 430        
 Ala Gly Ser Ser Thr Ser Lys Glu Ala Tyr Ile
         435                 440            



      <210> 2322
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 2322
 Met Met Tyr Ile Leu Leu Val Phe Leu Thr Leu Trp Leu Leu Ile Glu
   1               5                  10                  15    
 Met Ile His Cys Leu Gln Asn Gly Asp His Arg Arg Thr Arg Pro Pro
              20                  25                  30        
 Thr Glu Thr Gly Trp Leu Pro Leu Arg Phe His Leu Arg Thr Gly Lys
          35                  40                  45            
 Ile Leu Arg Tyr Leu Arg Gly Glu
      50                  55    



      <210> 2323
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 2323
 Met Ser Ala Leu Arg Pro Leu Leu Leu Leu Leu Leu Pro Leu Cys Pro
   1               5                  10                  15    
 Gly Pro Gly Pro Gly Pro Gly Ser Glu Ala Lys Val Thr Arg Ser Cys
              20                  25                  30        
 Ala Glu Thr Arg Gln Val Leu Gly Ala Arg Gly Tyr Ser Leu Asn Leu
          35                  40                  45            
 Ile Pro Pro Ala Leu Ile Ser Gly Glu His Leu Arg Val Cys Pro Gln
      50                  55                  60                
 Glu Tyr Thr Cys Cys Ser Ser Glu Thr Glu Gln Arg Leu Ile Arg Glu
  65                  70                  75                  80
 Thr Glu Ala Thr Phe Arg Gly Leu Val Glu Asp Ser Gly Ser Phe Leu
                  85                  90                  95    
 Val His Thr Leu Ala Ala Arg His Arg Lys Phe Asp Glu Phe Phe Leu
             100                 105                 110        
 Glu Met Leu Phe Glu Thr Leu Ala Phe Phe Cys Pro Asp Leu Ser Ser
         115                 120                 125            
 His Ser Thr Gly Ala
     130            



      <210> 2324
      <211> 658
      <212> PRT
      <213> Homo sapiens


      <400> 2324
 Gly Thr Ala Glu Thr Phe His Ser Val His Phe Cys Pro Gln Pro Val
   1               5                  10                  15    
 Pro Lys Ala Pro Glu Ser Pro Ser Leu Asp Ser Ala Leu Ala Ser Pro
              20                  25                  30        
 Leu Asp Pro Gln Ala Leu Ala Cys Thr Pro Ala Ser Pro Pro Asp Ser
          35                  40                  45            
 Gln Pro Pro Ala Ser Pro Gln Asp Ser Glu Ala Leu Asp Phe Glu Thr
      50                  55                  60                
 Pro Ser Ser Ser Leu Ala Pro Gln Thr Pro Asp Ser Ala Leu Ala Ser
  65                  70                  75                  80
 Glu Thr Leu Ala Ser Pro Gln Ser Leu Pro Pro Ala Ser Pro Leu Leu
                  85                  90                  95    
 Glu Asp Arg Glu Glu Gly Asp Leu Gly Lys Ala Ser Glu Leu Ala Glu
             100                 105                 110        
 Thr Pro Lys Glu Glu Lys Ala Glu Gly Ala Ala Met Leu Glu Leu Val
         115                 120                 125            
 Gly Ser Ile Leu Arg Gly Cys Val Pro Gly Val Tyr Arg Val Gln Thr
     130                 135                 140                
 Val Pro Ser Ala Arg Arg Pro Val Val Lys Phe Cys His Arg Pro Ser
 145                 150                 155                 160
 Gly Leu His Gly Asp Val Ser Leu Ser Asn Arg Leu Ala Leu His Asn
                 165                 170                 175    
 Ser Arg Phe Leu Ser Leu Cys Ser Glu Leu Asp Gly Arg Val Arg Pro
             180                 185                 190        
 Leu Val Tyr Thr Leu Arg Cys Trp Ala Gln Gly Arg Gly Leu Ser Gly
         195                 200                 205            
 Ser Gly Pro Leu Leu Ser Asn Tyr Ala Leu Thr Leu Leu Val Ile Tyr
     210                 215                 220                
 Phe Leu Gln Thr Arg Asp Pro Pro Val Leu Pro Thr Val Ser Gln Leu
 225                 230                 235                 240
 Thr Gln Lys Ala Gly Glu Gly Glu Gln Val Glu Val Asp Gly Trp Asp
                 245                 250                 255    
 Cys Ser Phe Pro Arg Asp Ala Ser Arg Leu Glu Pro Ser Ile Asn Val
             260                 265                 270        
 Glu Pro Leu Ser Ser Leu Leu Ala Gln Phe Phe Ser Cys Val Ser Cys
         275                 280                 285            
 Trp Asp Leu Arg Gly Ser Leu Leu Ser Leu Arg Glu Gly Gln Ala Leu
     290                 295                 300                
 Pro Val Ala Gly Gly Leu Pro Ser Asn Leu Trp Glu Gly Leu Arg Leu
 305                 310                 315                 320
 Gly Pro Leu Asn Leu Gln Asp Pro Phe Asp Leu Ser His Asn Val Ala
                 325                 330                 335    
 Ala Asn Val Thr Ser Arg Val Ala Gly Arg Leu Gln Asn Cys Cys Arg
             340                 345                 350        
 Ala Ala Ala Asn Tyr Cys Arg Ser Leu Gln Tyr Gln Arg Arg Ser Ser
         355                 360                 365            
 Arg Gly Arg Asp Trp Gly Leu Leu Pro Leu Leu Gln Pro Ser Ser Pro
     370                 375                 380                
 Ser Ser Leu Leu Ser Ala Thr Pro Ile Pro Leu Pro Leu Ala Pro Phe
 385                 390                 395                 400
 Thr Gln Leu Thr Ala Ala Leu Val Gln Val Phe Arg Glu Ala Leu Gly
                 405                 410                 415    
 Cys His Ile Glu Gln Ala Thr Lys Arg Thr Arg Ser Glu Gly Gly Gly
             420                 425                 430        
 Thr Gly Glu Ser Ser Gln Gly Gly Thr Ser Lys Arg Leu Lys Val Asp
         435                 440                 445            
 Gly Gln Lys Asn Cys Cys Glu Glu Gly Lys Glu Glu Gln Gln Gly Cys
     450                 455                 460                
 Ala Gly Asp Gly Gly Glu Asp Arg Val Glu Glu Met Val Ile Glu Val
 465                 470                 475                 480
 Gly Glu Met Val Gln Asp Trp Ala Met Gln Ser Pro Gly Gln Pro Gly
                 485                 490                 495    
 Asp Leu Pro Leu Thr Thr Gly Lys His Gly Ala Pro Gly Glu Glu Gly
             500                 505                 510        
 Gln Pro Ser His Ala Ala Leu Ala Glu Arg Gly Pro Lys Gly His Glu
         515                 520                 525            
 Ala Ala Gln Glu Trp Ser Gln Gly Glu Ala Gly Lys Gly Ala Ser Leu
     530                 535                 540                
 Pro Ser Ser Ala Ser Trp Arg Cys Ala Leu Trp His Arg Val Trp Gln
 545                 550                 555                 560
 Gly Arg Arg Arg Ala Arg Arg Arg Leu Gln Gln Gln Thr Lys Glu Gly
                 565                 570                 575    
 Ala Gly Gly Gly Ala Gly Thr Arg Ala Gly Trp Leu Ala Thr Glu Ala
             580                 585                 590        
 Gln Val Thr Gln Glu Leu Lys Gly Leu Ser Gly Gly Glu Glu Arg Pro
         595                 600                 605            
 Glu Thr Glu Pro Leu Leu Ser Phe Val Ala Ser Val Ser Pro Ala Asp
     610                 615                 620                
 Arg Met Leu Thr Val Thr Pro Leu Gln Asp Pro Gln Gly Leu Phe Pro
 625                 630                 635                 640
 Asp Leu His His Phe Leu Gln Val Phe Leu Pro Gln Ala Ile Arg His
                 645                 650                 655    
 Leu Lys
        



      <210> 2325
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 2325
 Ser Leu Ser Met Cys Arg Glu Val His Val Tyr Glu Tyr Ile Pro Ser
   1               5                  10                  15    
 Val Arg Gln Thr Glu Leu Cys His Tyr His Glu Leu Tyr Tyr Asp Ala
              20                  25                  30        
 Ala Cys Thr Leu Gly Ala Tyr His Pro Leu Leu Tyr Glu Lys Leu Leu
          35                  40                  45            
 Val Gln Arg Leu Asn Met Gly Thr Gln Gly Asp Leu His Arg Lys Gly
      50                  55                  60                
 Lys Val Val Leu Pro Gly Phe Gln Ala Val His Cys Pro Ala Pro Ser
  65                  70                  75                  80
 Pro Val Ile Pro His Ser
                  85    



      <210> 2326
      <211> 403
      <212> PRT
      <213> Homo sapiens


      <400> 2326
 Ala Ser Leu Cys Lys Gly Cys Phe Phe Val Thr His Val Leu Val Ile
   1               5                  10                  15    
 Ile Leu Pro Ser Leu Gln Ser Pro Pro Thr Phe Gly Phe Leu Leu Asp
              20                  25                  30        
 Ile Asp Gly Val Leu Val Arg Gly His Arg Val Ile Pro Ala Ala Leu
          35                  40                  45            
 Lys Ala Phe Arg Arg Leu Val Asn Ser Gln Gly Gln Leu Arg Val Pro
      50                  55                  60                
 Val Val Phe Val Thr Asn Ala Gly Asn Ile Leu Gln His Ser Lys Ala
  65                  70                  75                  80
 Gln Glu Leu Ser Ala Leu Leu Gly Cys Glu Val Asp Ala Asp Gln Val
                  85                  90                  95    
 Ile Leu Ser His Ser Pro Met Lys Leu Phe Ser Glu Tyr His Glu Lys
             100                 105                 110        
 Arg Met Leu Val Ser Gly Gln Gly Pro Val Met Glu Asn Ala Gln Gly
         115                 120                 125            
 Leu Gly Phe Arg Asn Val Val Thr Val Asp Glu Leu Arg Met Ala Phe
     130                 135                 140                
 Pro Leu Leu Asp Met Val Asp Leu Glu Arg Arg Leu Lys Thr Thr Pro
 145                 150                 155                 160
 Leu Pro Arg Asn Asp Phe Pro Arg Ile Glu Gly Val Leu Leu Leu Gly
                 165                 170                 175    
 Glu Pro Val Arg Trp Glu Thr Ser Leu Gln Leu Ile Met Asp Val Leu
             180                 185                 190        
 Leu Ser Asn Gly Ser Pro Gly Ala Gly Leu Ala Thr Pro Pro Tyr Pro
         195                 200                 205            
 His Leu Pro Val Leu Ala Ser Asn Met Asp Leu Leu Trp Met Ala Glu
     210                 215                 220                
 Ala Lys Met Pro Arg Phe Gly His Gly Thr Phe Leu Leu Cys Leu Glu
 225                 230                 235                 240
 Thr Ile Tyr Gln Lys Val Thr Gly Lys Glu Leu Arg Tyr Glu Gly Leu
                 245                 250                 255    
 Met Gly Lys Pro Ser Ile Leu Thr Tyr Gln Tyr Ala Glu Asp Leu Ile
             260                 265                 270        
 Arg Arg Gln Ala Glu Arg Arg Gly Trp Ala Ala Pro Ile Arg Lys Leu
         275                 280                 285            
 Tyr Ala Val Gly Asp Asn Pro Met Ser Asp Val Tyr Gly Ala Asn Leu
     290                 295                 300                
 Phe His Gln Tyr Leu Gln Lys Ala Thr His Asp Gly Ala Pro Glu Leu
 305                 310                 315                 320
 Gly Ala Gly Gly Thr Arg Gln Gln Gln Pro Ser Ala Ser Gln Ser Cys
                 325                 330                 335    
 Ile Ser Ile Leu Val Cys Thr Gly Val Tyr Asn Pro Arg Asn Pro Gln
             340                 345                 350        
 Ser Thr Glu Pro Val Leu Gly Gly Gly Glu Pro Pro Phe His Gly His
         355                 360                 365            
 Arg Asp Leu Cys Phe Ser Pro Gly Leu Met Glu Ala Ser His Val Val
     370                 375                 380                
 Asn Asp Val Asn Glu Ala Val Gln Leu Val Phe Arg Lys Glu Gly Trp
 385                 390                 395                 400
 Ala Leu Glu
            



      <210> 2327
      <211> 403
      <212> PRT
      <213> Homo sapiens


      <400> 2327
 Ala Ser Leu Cys Lys Gly Cys Phe Phe Val Thr His Val Leu Val Ile
   1               5                  10                  15    
 Ile Leu Pro Ser Leu Gln Ser Pro Pro Thr Phe Gly Phe Leu Leu Asp
              20                  25                  30        
 Ile Asp Gly Val Leu Val Arg Gly His Arg Val Ile Pro Ala Ala Leu
          35                  40                  45            
 Lys Ala Phe Arg Arg Leu Val Asn Ser Gln Gly Gln Leu Arg Val Pro
      50                  55                  60                
 Val Val Phe Val Thr Asn Ala Gly Asn Ile Leu Gln His Ser Lys Ala
  65                  70                  75                  80
 Gln Glu Leu Ser Ala Leu Leu Gly Cys Glu Val Asp Ala Asp Gln Val
                  85                  90                  95    
 Ile Leu Ser His Ser Pro Met Lys Leu Phe Ser Glu Tyr His Glu Lys
             100                 105                 110        
 Arg Met Leu Val Ser Gly Gln Gly Pro Val Met Glu Asn Ala Gln Gly
         115                 120                 125            
 Leu Gly Phe Arg Asn Val Val Thr Val Asp Glu Leu Arg Met Ala Phe
     130                 135                 140                
 Pro Leu Leu Asp Met Val Asp Leu Glu Arg Arg Leu Lys Thr Thr Pro
 145                 150                 155                 160
 Leu Pro Arg Asn Asp Phe Pro Arg Ile Glu Gly Val Leu Leu Leu Gly
                 165                 170                 175    
 Glu Pro Val Arg Trp Glu Thr Ser Leu Gln Leu Ile Met Asp Val Leu
             180                 185                 190        
 Leu Ser Asn Gly Ser Pro Gly Ala Gly Leu Ala Thr Pro Pro Tyr Pro
         195                 200                 205            
 His Leu Pro Val Leu Ala Ser Asn Met Asp Leu Leu Trp Met Ala Glu
     210                 215                 220                
 Ala Lys Met Pro Arg Phe Gly His Gly Thr Phe Leu Leu Cys Leu Glu
 225                 230                 235                 240
 Thr Ile Tyr Gln Lys Val Thr Gly Lys Glu Leu Arg Tyr Glu Gly Leu
                 245                 250                 255    
 Met Gly Lys Pro Ser Ile Leu Thr Tyr Gln Tyr Ala Glu Asp Leu Ile
             260                 265                 270        
 Arg Arg Gln Ala Glu Arg Arg Gly Trp Ala Ala Pro Ile Arg Lys Leu
         275                 280                 285            
 Tyr Ala Val Gly Asp Asn Pro Met Ser Asp Val Tyr Gly Ala Asn Leu
     290                 295                 300                
 Phe His Gln Tyr Leu Gln Lys Ala Thr His Asp Gly Ala Pro Glu Leu
 305                 310                 315                 320
 Gly Ala Gly Gly Thr Arg Gln Gln Gln Pro Ser Ala Ser Gln Ser Cys
                 325                 330                 335    
 Ile Ser Ile Leu Val Cys Thr Gly Val Tyr Asn Pro Arg Asn Pro Gln
             340                 345                 350        
 Ser Thr Glu Pro Val Leu Gly Gly Gly Glu Pro Pro Phe His Gly His
         355                 360                 365            
 Arg Asp Leu Cys Phe Ser Pro Gly Leu Met Glu Ala Ser His Val Val
     370                 375                 380                
 Asn Asp Val Asn Glu Ala Val Gln Leu Val Phe Arg Lys Glu Gly Trp
 385                 390                 395                 400
 Ala Leu Glu
            



      <210> 2328
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 2328
 Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser Ser
   1               5                  10                  15    
 Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu Thr
              20                  25                  30        
 Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln Lys
          35                  40                  45            
 Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln Arg
      50                  55                  60                
 Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu
  65                  70                  75                  80
 Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Val Pro Ser Glu Glu
                  85                  90                  95    
 Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe Asn
             100                 105                 110        
 Ile Gln Ala Val Asn Arg Met
         115                



      <210> 2329
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 2329
 Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser Ser
   1               5                  10                  15    
 Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu Thr
              20                  25                  30        
 Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln Lys
          35                  40                  45            
 Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln Arg
      50                  55                  60                
 Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu
  65                  70                  75                  80
 Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Val Pro Ser Glu Glu
                  85                  90                  95    
 Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe Asn
             100                 105                 110        
 Ile Gln Ala Val Asn Arg Met
         115                



      <210> 2330
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 2330
 Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser Ser
   1               5                  10                  15    
 Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu Thr
              20                  25                  30        
 Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln Lys
          35                  40                  45            
 Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln Arg
      50                  55                  60                
 Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu
  65                  70                  75                  80
 Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Val Pro Ser Glu Glu
                  85                  90                  95    
 Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe Asn
             100                 105                 110        
 Ile Gln Ala Val Asn Arg Met
         115                



      <210> 2331
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 2331
 Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser Ser
   1               5                  10                  15    
 Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu Thr
              20                  25                  30        
 Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln Lys
          35                  40                  45            
 Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln Arg
      50                  55                  60                
 Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu
  65                  70                  75                  80
 Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Val Pro Ser Glu Glu
                  85                  90                  95    
 Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe Asn
             100                 105                 110        
 Ile Gln Ala Val Asn Arg Met
         115                



      <210> 2332
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 2332
 Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser Ser
   1               5                  10                  15    
 Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu Thr
              20                  25                  30        
 Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln Lys
          35                  40                  45            
 Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln Arg
      50                  55                  60                
 Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu
  65                  70                  75                  80
 Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Val Pro Ser Glu Glu
                  85                  90                  95    
 Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe Asn
             100                 105                 110        
 Ile Gln Ala Val Asn Arg Met
         115                



      <210> 2333
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 2333
 Met Glu Ser Ala Val Arg Val Glu Ser Gly Val Leu Val Gly Val Val
   1               5                  10                  15    
 Cys Leu Leu Leu Ala Cys Pro Ala Thr Ala Thr Gly Pro Glu Val Ala
              20                  25                  30        
 Gln Pro Glu Val Asp Thr Thr Leu Gly Arg Val Arg Gly Arg Gln Val
          35                  40                  45            
 Gly Val Lys Gly Thr Asp Arg Leu Val Asn Val Phe Leu Gly Ile Pro
      50                  55                  60                
 Phe Ala Gln Pro Pro Leu Gly Pro Asp Arg Phe Ser Ala Pro His Pro
  65                  70                  75                  80
 Ala Gln Pro Trp Glu Gly Val Arg Asp Ala Ser Thr Ala Pro Pro Met
                  85                  90                  95    
 Cys Leu Gln Asp Val Glu Ser Met Asn Ser Ser Arg Phe Val Leu Asn
             100                 105                 110        
 Gly Lys Gln Gln Ile Phe Ser Val Ser Glu Asp Cys Leu Val Leu Asn
         115                 120                 125            
 Val Tyr Ser Pro Ala Glu Val Pro Ala Gly Ser Gly Arg Pro
     130                 135                 140        



      <210> 2334
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 2334
 Ala Ala Ser Thr Thr Asp Gly Ser Tyr Lys Cys Leu Cys Leu Pro Gly
   1               5                  10                  15    
 Tyr Val Pro Ser Asp Lys Pro Asn Tyr Cys Thr Pro Leu Asn Thr Ala
              20                  25                  30        
 Leu Asn Leu Glu Lys Cys Pro Phe Gly Leu Pro His Leu Ser Gly Ser
          35                  40                  45            
 Ser
    



      <210> 2335
      <211> 101
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(101)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2335
 Pro Ala Ser Pro Pro Arg Trp Gly Cys Trp Gly Cys Trp Gly Arg Trp
   1               5                  10                  15    
 Asp Cys Phe Ala Ser Arg Ser Pro Trp Ala Arg Ser Xaa Ser Arg Arg
              20                  25                  30        
 Pro Pro Arg Ser Thr Ala Ala Ala Pro Arg Ser Pro Ala Arg Pro Arg
          35                  40                  45            
 Thr Cys Ala Gly Cys Thr Arg Arg Thr Trp Lys Thr Gly Arg Pro Ala
      50                  55                  60                
 Arg Ser Arg Arg Ser Gly Arg Thr Pro Arg Ala Gly Arg Xaa Lys Xaa
  65                  70                  75                  80
 Ser Pro Gly Ser Gly Thr Arg Thr Ser Arg Pro Gly Gly Arg Arg Arg
                  85                  90                  95    
 Pro Ala Gly Ala Arg
             100    



      <210> 2336
      <211> 270
      <212> PRT
      <213> Homo sapiens


      <400> 2336
 Thr His Ala Ser Glu Asn Ala His Gly Gln Ala Ser Ser Phe Ala Asn
   1               5                  10                  15    
 Phe Leu Val Arg Thr Tyr Leu Gly Lys Asp Ala Gly Phe Asp Ser Glu
              20                  25                  30        
 Ile Phe Lys Arg Ser Thr Phe Gly Pro Ser Val Glu Phe Thr Ser Val
          35                  40                  45            
 Leu Lys Pro Val Phe Ala Arg Glu Lys Glu Pro Phe Ser Leu Ser Cys
      50                  55                  60                
 Leu Phe Ser Glu Asp Val Leu Asp Ala Glu Ser Ile Gln Trp Phe Arg
  65                  70                  75                  80
 Asp Gly Ser Leu Leu Arg Ser Ser Arg Arg Arg Lys Ile Leu Tyr Thr
                  85                  90                  95    
 Asp Arg Gln Ala Ser Leu Lys Val Ser Cys Thr Tyr Lys Glu Asp Glu
             100                 105                 110        
 Gly Leu Tyr Met Val Arg Val Pro Ser Pro Phe Gly Pro Arg Glu Gln
         115                 120                 125            
 Ser Thr Tyr Val Leu Val Arg Asp Ala Glu Ala Glu Asn Pro Gly Ala
     130                 135                 140                
 Pro Gly Ser Pro Leu Asn Val Arg Cys Leu Asp Val Asn Arg Asp Cys
 145                 150                 155                 160
 Leu Ile Leu Thr Trp Ala Pro Pro Ser Asp Thr Arg Gly Asn Pro Ile
                 165                 170                 175    
 Thr Ala Tyr Thr Ile Glu Arg Cys Gln Gly Glu Ser Gly Glu Trp Ile
             180                 185                 190        
 Ala Cys His Glu Ala Pro Gly Gly Thr Cys Arg Cys Pro Ile Gln Gly
         195                 200                 205            
 Leu Val Glu Gly Gln Ser Tyr Arg Phe Arg Val Arg Ala Ile Ser Arg
     210                 215                 220                
 Val Gly Ser Ser Val Pro Ser Lys Ala Ser Glu Leu Val Val Met Gly
 225                 230                 235                 240
 Asp His Asp Ala Ala Arg Arg Lys Thr Glu Ile Pro Phe Asp Leu Gly
                 245                 250                 255    
 Asn Lys Ile Thr Ile Ser Thr Asp Ala Phe Glu Asp Thr Val
             260                 265                 270



      <210> 2337
      <211> 69
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(69)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2337
 Asp Ile Arg Glu Tyr Lys Xaa Asn Asn Pro Leu Val His Met Arg Thr
   1               5                  10                  15    
 Asp Glu Thr Xaa Met Thr Met Lys Xaa Xaa Met Val Lys Glu Lys Lys
              20                  25                  30        
 Ile Val Lys Glu Asp Trp Arg Lys Val His Leu Ala Ser Xaa Gln Ser
          35                  40                  45            
 Phe Pro Ser Phe Phe Val Ile Glu His Ser Lys Ala Ile Arg Gly Ser
      50                  55                  60                
 Trp Phe Pro Gln Leu
  65                



      <210> 2338
      <211> 69
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(69)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2338
 Asp Ile Arg Glu Tyr Lys Xaa Asn Asn Pro Leu Val His Met Arg Thr
   1               5                  10                  15    
 Asp Glu Thr Xaa Met Thr Met Lys Xaa Xaa Met Val Lys Glu Lys Lys
              20                  25                  30        
 Ile Val Lys Glu Asp Trp Arg Lys Val His Leu Ala Ser Xaa Gln Ser
          35                  40                  45            
 Phe Pro Ser Phe Phe Val Ile Glu His Ser Lys Ala Ile Arg Gly Ser
      50                  55                  60                
 Trp Phe Pro Gln Leu
  65                



      <210> 2339
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 2339
 Pro Gly Ala Pro Arg Val Arg Leu Glu Thr His Pro Glu Pro Leu Pro
   1               5                  10                  15    
 Ser Asp Thr Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln
              20                  25                  30        
 Gly Cys Gly Leu Glu Thr Cys Cys Arg Pro Ser Cys Cys Gln Thr Thr
          35                  40                  45            
 Cys Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys
      50                  55                  60                
 Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys
  65                  70                  75                  80
 Arg Pro Ser Cys Cys Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr
                  85                  90                  95    
 Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln
             100                 105                 110        
 Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys
         115                 120                 125            
 Ser Ile Ser Ser Cys Cys Arg Pro Ser Cys Cys Val Ser Arg Cys Cys
     130                 135                 140                
 Arg Ser Gln Arg Cys
 145                



      <210> 2340
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 2340
 Pro Gly Ala Pro Arg Val Arg Leu Glu Thr His Pro Glu Pro Leu Pro
   1               5                  10                  15    
 Ser Asp Thr Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln
              20                  25                  30        
 Gly Cys Gly Leu Glu Thr Cys Cys Arg Pro Ser Cys Cys Gln Thr Thr
          35                  40                  45            
 Cys Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys
      50                  55                  60                
 Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys
  65                  70                  75                  80
 Arg Pro Ser Cys Cys Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr
                  85                  90                  95    
 Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln
             100                 105                 110        
 Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys
         115                 120                 125            
 Ser Ile Ser Ser Cys Cys Arg Pro Ser Cys Cys Val Ser Arg Cys Cys
     130                 135                 140                
 Arg Ser Gln Arg Cys
 145                



      <210> 2341
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 2341
 Pro Gly Ala Pro Arg Val Arg Leu Glu Thr His Pro Glu Pro Leu Pro
   1               5                  10                  15    
 Ser Asp Thr Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln
              20                  25                  30        
 Gly Cys Gly Leu Glu Thr Cys Cys Arg Pro Ser Cys Cys Gln Thr Thr
          35                  40                  45            
 Cys Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys
      50                  55                  60                
 Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys
  65                  70                  75                  80
 Arg Pro Ser Cys Cys Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr
                  85                  90                  95    
 Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln
             100                 105                 110        
 Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys
         115                 120                 125            
 Ser Ile Ser Ser Cys Cys Arg Pro Ser Cys Cys Val Ser Arg Cys Cys
     130                 135                 140                
 Arg Ser Gln Arg Cys
 145                



      <210> 2342
      <211> 465
      <212> PRT
      <213> Homo sapiens


      <400> 2342
 Ala Cys Leu Ile Cys Phe Arg Ile Gly Arg Gly Asn Cys Ser Arg Lys
   1               5                  10                  15    
 Ile Cys Glu Glu Phe Leu Asn Pro Gln Ile Leu Leu Thr Leu Glu Leu
              20                  25                  30        
 Val Val Thr Leu Ala Gly Lys Asn Lys Cys Arg Cys Trp Thr Met Leu
          35                  40                  45            
 Glu Thr Leu Ser Arg Gln Trp Ile Val Ser His Arg Met Glu Met Trp
      50                  55                  60                
 Leu Leu Ile Leu Val Ala Tyr Met Phe Gln Arg Asn Val Asn Ser Val
  65                  70                  75                  80
 His Met Pro Thr Lys Ala Val Asp Pro Glu Ala Phe Met Asn Ile Ser
                  85                  90                  95    
 Glu Ile Ile Gln His Gln Gly Tyr Pro Cys Glu Glu Tyr Glu Val Ala
             100                 105                 110        
 Thr Glu Asp Gly Tyr Ile Leu Ser Val Asn Arg Ile Pro Arg Gly Leu
         115                 120                 125            
 Val Gln Pro Lys Lys Thr Gly Ser Arg Pro Val Val Leu Leu Gln His
     130                 135                 140                
 Gly Leu Val Gly Gly Ala Ser Asn Trp Ile Ser Asn Leu Pro Asn Asn
 145                 150                 155                 160
 Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly
                 165                 170                 175    
 Asn Ser Arg Gly Asn Ala Trp Ser Arg Lys His Lys Thr Leu Ser Ile
             180                 185                 190        
 Asp Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Arg Phe
         195                 200                 205            
 Asp Leu Pro Ala Val Ile Asn Phe Ile Leu Gln Lys Thr Gly Gln Glu
     210                 215                 220                
 Lys Ile Tyr Tyr Val Gly Tyr Ser Gln Gly Thr Thr Met Gly Phe Ile
 225                 230                 235                 240
 Ala Phe Ser Thr Met Pro Glu Leu Ala Gln Lys Ile Lys Met Tyr Phe
                 245                 250                 255    
 Ala Leu Ala Pro Ile Ala Thr Val Lys His Ala Lys Ser Pro Gly Thr
             260                 265                 270        
 Lys Phe Leu Leu Leu Pro Asp Met Met Ile Lys Gly Leu Phe Gly Lys
         275                 280                 285            
 Lys Glu Phe Leu Tyr Gln Thr Arg Phe Leu Arg Gln Leu Val Ile Tyr
     290                 295                 300                
 Leu Cys Gly Gln Val Ile Leu Asp Gln Ile Cys Ser Asn Ile Met Leu
 305                 310                 315                 320
 Leu Leu Gly Gly Phe Asn Thr Asn Asn Met Asn Met Ser Arg Ala Ser
                 325                 330                 335    
 Val Tyr Ala Ala His Thr Leu Ala Gly Thr Ser Val Gln Asn Ile Leu
             340                 345                 350        
 His Trp Ser Gln Ala Val Asn Ser Gly Glu Leu Arg Ala Phe Asp Trp
         355                 360                 365            
 Gly Ser Glu Thr Lys Asn Leu Glu Lys Cys Asn Gln Pro Thr Pro Val
     370                 375                 380                
 Arg Tyr Arg Val Arg Asp Met Thr Val Pro Thr Ala Met Trp Thr Gly
 385                 390                 395                 400
 Gly Gln Asp Trp Leu Ser Asn Pro Glu Asp Val Lys Met Leu Leu Ser
                 405                 410                 415    
 Glu Val Thr Asn Leu Ile Tyr His Lys Asn Ile Pro Glu Trp Ala His
             420                 425                 430        
 Val Asp Phe Ile Trp Gly Leu Asp Ala Pro His Arg Met Tyr Asn Glu
         435                 440                 445            
 Ile Ile His Leu Met His Gln Glu Glu Thr Gln Pro Phe Pro Arg Thr
     450                 455                 460                
 Ala
 465



      <210> 2343
      <211> 465
      <212> PRT
      <213> Homo sapiens


      <400> 2343
 Ala Cys Leu Ile Cys Phe Arg Ile Gly Arg Gly Asn Cys Ser Arg Lys
   1               5                  10                  15    
 Ile Cys Glu Glu Phe Leu Asn Pro Gln Ile Leu Leu Thr Leu Glu Leu
              20                  25                  30        
 Val Val Thr Leu Ala Gly Lys Asn Lys Cys Arg Cys Trp Thr Met Leu
          35                  40                  45            
 Glu Thr Leu Ser Arg Gln Trp Ile Val Ser His Arg Met Glu Met Trp
      50                  55                  60                
 Leu Leu Ile Leu Val Ala Tyr Met Phe Gln Arg Asn Val Asn Ser Val
  65                  70                  75                  80
 His Met Pro Thr Lys Ala Val Asp Pro Glu Ala Phe Met Asn Ile Ser
                  85                  90                  95    
 Glu Ile Ile Gln His Gln Gly Tyr Pro Cys Glu Glu Tyr Glu Val Ala
             100                 105                 110        
 Thr Glu Asp Gly Tyr Ile Leu Ser Val Asn Arg Ile Pro Arg Gly Leu
         115                 120                 125            
 Val Gln Pro Lys Lys Thr Gly Ser Arg Pro Val Val Leu Leu Gln His
     130                 135                 140                
 Gly Leu Val Gly Gly Ala Ser Asn Trp Ile Ser Asn Leu Pro Asn Asn
 145                 150                 155                 160
 Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly
                 165                 170                 175    
 Asn Ser Arg Gly Asn Ala Trp Ser Arg Lys His Lys Thr Leu Ser Ile
             180                 185                 190        
 Asp Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Arg Phe
         195                 200                 205            
 Asp Leu Pro Ala Val Ile Asn Phe Ile Leu Gln Lys Thr Gly Gln Glu
     210                 215                 220                
 Lys Ile Tyr Tyr Val Gly Tyr Ser Gln Gly Thr Thr Met Gly Phe Ile
 225                 230                 235                 240
 Ala Phe Ser Thr Met Pro Glu Leu Ala Gln Lys Ile Lys Met Tyr Phe
                 245                 250                 255    
 Ala Leu Ala Pro Ile Ala Thr Val Lys His Ala Lys Ser Pro Gly Thr
             260                 265                 270        
 Lys Phe Leu Leu Leu Pro Asp Met Met Ile Lys Gly Leu Phe Gly Lys
         275                 280                 285            
 Lys Glu Phe Leu Tyr Gln Thr Arg Phe Leu Arg Gln Leu Val Ile Tyr
     290                 295                 300                
 Leu Cys Gly Gln Val Ile Leu Asp Gln Ile Cys Ser Asn Ile Met Leu
 305                 310                 315                 320
 Leu Leu Gly Gly Phe Asn Thr Asn Asn Met Asn Met Ser Arg Ala Ser
                 325                 330                 335    
 Val Tyr Ala Ala His Thr Leu Ala Gly Thr Ser Val Gln Asn Ile Leu
             340                 345                 350        
 His Trp Ser Gln Ala Val Asn Ser Gly Glu Leu Arg Ala Phe Asp Trp
         355                 360                 365            
 Gly Ser Glu Thr Lys Asn Leu Glu Lys Cys Asn Gln Pro Thr Pro Val
     370                 375                 380                
 Arg Tyr Arg Val Arg Asp Met Thr Val Pro Thr Ala Met Trp Thr Gly
 385                 390                 395                 400
 Gly Gln Asp Trp Leu Ser Asn Pro Glu Asp Val Lys Met Leu Leu Ser
                 405                 410                 415    
 Glu Val Thr Asn Leu Ile Tyr His Lys Asn Ile Pro Glu Trp Ala His
             420                 425                 430        
 Val Asp Phe Ile Trp Gly Leu Asp Ala Pro His Arg Met Tyr Asn Glu
         435                 440                 445            
 Ile Ile His Leu Met His Gln Glu Glu Thr Gln Pro Phe Pro Arg Thr
     450                 455                 460                
 Ala
 465



      <210> 2344
      <211> 317
      <212> PRT
      <213> Homo sapiens


      <400> 2344
 Val Thr Met Tyr Lys Asp Cys Ile Glu Ser Thr Gly Asp Tyr Phe Leu
   1               5                  10                  15    
 Leu Cys Asp Ala Glu Gly Pro Trp Gly Ile Ile Leu Glu Ser Leu Ala
              20                  25                  30        
 Ile Leu Gly Ile Val Val Thr Ile Leu Leu Leu Leu Ala Phe Leu Phe
          35                  40                  45            
 Leu Met Arg Lys Ile Gln Asp Cys Ser Gln Trp Asn Val Leu Pro Thr
      50                  55                  60                
 Gln Leu Leu Phe Leu Leu Ser Val Leu Gly Leu Phe Gly Leu Ala Phe
  65                  70                  75                  80
 Ala Phe Ile Ile Glu Leu Asn Gln Gln Thr Ala Pro Val Arg Tyr Phe
                  85                  90                  95    
 Leu Phe Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu Ala His
             100                 105                 110        
 Ala Ser Asn Leu Val Lys Leu Val Arg Gly Cys Val Ser Phe Ser Trp
         115                 120                 125            
 Thr Thr Ile Leu Cys Ile Ala Ile Gly Cys Ser Leu Leu Gln Ile Ile
     130                 135                 140                
 Ile Ala Thr Glu Tyr Val Thr Leu Ile Met Thr Arg Gly Met Met Phe
 145                 150                 155                 160
 Val Asn Met Thr Pro Cys Gln Leu Asn Val Asp Phe Val Val Leu Leu
                 165                 170                 175    
 Val Tyr Val Leu Phe Leu Met Ala Leu Thr Phe Phe Val Ser Lys Ala
             180                 185                 190        
 Thr Phe Cys Gly Pro Cys Glu Asn Trp Lys Gln His Gly Arg Leu Ile
         195                 200                 205            
 Phe Ile Thr Val Leu Phe Ser Ile Ile Ile Trp Val Val Trp Ile Ser
     210                 215                 220                
 Met Leu Leu Arg Gly Asn Pro Gln Phe Gln Arg Gln Pro Gln Trp Asp
 225                 230                 235                 240
 Asp Pro Val Val Cys Ile Ala Leu Val Thr Asn Ala Trp Val Phe Leu
                 245                 250                 255    
 Leu Leu Tyr Ile Val Pro Glu Leu Cys Ile Leu Tyr Arg Ser Cys Arg
             260                 265                 270        
 Gln Glu Cys Pro Leu Gln Gly Asn Ala Cys Pro Val Thr Ala Tyr Gln
         275                 280                 285            
 His Ser Phe Gln Val Glu Asn Gln Glu Leu Ser Arg Asp Lys Trp Lys
     290                 295                 300                
 Val Leu Leu Asn Ser Asp Phe Leu Ser His Ser Gly Ala
 305                 310                 315        



      <210> 2345
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 2345
 Ala His Thr Met Val Pro Glu Glu Glu Pro Gln Asp Arg Glu Lys Gly
   1               5                  10                  15    
 Leu Trp Trp Val Gln Val Lys Val Trp Ser Met Ala Val Val Ser Ile
              20                  25                  30        
 Leu Leu Leu Ser Val Cys Phe Thr Val Ser Ser Val Val Pro His Asn
          35                  40                  45            
 Phe Met Tyr Ser Lys Thr Val Lys Arg Leu Ser Lys Leu Arg Glu Tyr
      50                  55                  60                
 Gln Gln Tyr His Ser Ser Leu Thr Cys Val Met Glu Gly Lys Asp Ile
  65                  70                  75                  80
 Glu Asp Trp Ser Cys Cys Pro Thr Pro Trp Thr Ser Phe Gln Ser Ser
                  85                  90                  95    
 Cys Tyr Phe Ile Ser Thr Gly Met Gln Ser Trp Thr Lys Ser Gln Lys
             100                 105                 110        
 Asn Cys Ser Val Met Gly Ala Asp Leu Val Val Ile Asn Thr Arg Glu
         115                 120                 125            
 Glu Gln Asp Phe Ile Ile Gln Asn Leu Lys Arg Asn Ser Ser Tyr Phe
     130                 135                 140                
 Leu Gly Leu Ser Asp Pro Gly Gly Arg Arg His Trp Gln Trp Val Asp
 145                 150                 155                 160
 Gln Thr Pro Tyr Asn Glu Asn Ser Arg Glu Tyr Arg Met Arg Phe Trp
                 165                 170                 175    
 His Ser Gly Glu Pro Asn Asn Leu Asp Glu Arg Cys Ala Ile Ile Asn
             180                 185                 190        
 Phe Arg Ser Ser Glu Glu Trp Gly Trp Asn Asp Ile His Cys His Val
         195                 200                 205            
 Pro Gln Lys Ser Ile Cys Lys Met Lys Lys Ile Tyr Ile
     210                 215                 220    



      <210> 2346
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 2346
 Ala His Thr Met Val Pro Glu Glu Glu Pro Gln Asp Arg Glu Lys Gly
   1               5                  10                  15    
 Leu Trp Trp Val Gln Val Lys Val Trp Ser Met Ala Val Val Ser Ile
              20                  25                  30        
 Leu Leu Leu Ser Val Cys Phe Thr Val Ser Ser Val Val Pro His Asn
          35                  40                  45            
 Phe Met Tyr Ser Lys Thr Val Lys Arg Leu Ser Lys Leu Arg Glu Tyr
      50                  55                  60                
 Gln Gln Tyr His Ser Ser Leu Thr Cys Val Met Glu Gly Lys Asp Ile
  65                  70                  75                  80
 Glu Asp Trp Ser Cys Cys Pro Thr Pro Trp Thr Ser Phe Gln Ser Ser
                  85                  90                  95    
 Cys Tyr Phe Ile Ser Thr Gly Met Gln Ser Trp Thr Lys Ser Gln Lys
             100                 105                 110        
 Asn Cys Ser Val Met Gly Ala Asp Leu Val Val Ile Asn Thr Arg Glu
         115                 120                 125            
 Glu Gln Asp Phe Ile Ile Gln Asn Leu Lys Arg Asn Ser Ser Tyr Phe
     130                 135                 140                
 Leu Gly Leu Ser Asp Pro Gly Gly Arg Arg His Trp Gln Trp Val Asp
 145                 150                 155                 160
 Gln Thr Pro Tyr Asn Glu Asn Ser Arg Glu Tyr Arg Met Arg Phe Trp
                 165                 170                 175    
 His Ser Gly Glu Pro Asn Asn Leu Asp Glu Arg Cys Ala Ile Ile Asn
             180                 185                 190        
 Phe Arg Ser Ser Glu Glu Trp Gly Trp Asn Asp Ile His Cys His Val
         195                 200                 205            
 Pro Gln Lys Ser Ile Cys Lys Met Lys Lys Ile Tyr Ile
     210                 215                 220    



      <210> 2347
      <211> 697
      <212> PRT
      <213> Homo sapiens


      <400> 2347
 Met Leu Val Leu Asn Ser Trp Ala Gln Val Ile His Trp Pro Gln Pro
   1               5                  10                  15    
 Pro Lys Val Leu Gly Leu Gln Pro Leu Glu Lys Thr Gln Tyr Gly Phe
              20                  25                  30        
 Leu Gly Thr Asp Arg Val Glu Glu Lys Thr Ser Val Ile Thr Ile Arg
          35                  40                  45            
 Val Ser Val Thr His Arg His Asn Ser Tyr Met Glu Ala Glu Asn Leu
      50                  55                  60                
 Thr Glu Leu Ser Lys Phe Leu Leu Leu Gly Leu Ser Asp Asp Pro Glu
  65                  70                  75                  80
 Leu Gln Pro Val Leu Phe Gly Leu Phe Leu Ser Met Tyr Leu Val Thr
                  85                  90                  95    
 Val Leu Gly Asn Leu Leu Ile Ile Leu Ala Val Ser Ser Asp Ser His
             100                 105                 110        
 Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Val Asp
         115                 120                 125            
 Ile Cys Phe Ile Ser Thr Thr Val Pro Lys Met Leu Val Ser Ile Gln
     130                 135                 140                
 Ala Arg Ser Lys Asp Ile Ser Tyr Met Gly Cys Leu Thr Gln Val Tyr
 145                 150                 155                 160
 Phe Leu Met Met Phe Ala Gly Met Asp Thr Phe Leu Leu Ala Val Met
                 165                 170                 175    
 Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro Leu His Tyr Thr Val
             180                 185                 190        
 Ile Met Asn Pro Cys Leu Cys Gly Leu Leu Val Leu Ala Ser Trp Phe
         195                 200                 205            
 Ile Ile Phe Trp Phe Ser Leu Val His Ile Leu Leu Met Lys Arg Leu
     210                 215                 220                
 Thr Phe Ser Thr Gly Thr Glu Ile Pro His Phe Phe Cys Glu Pro Ala
 225                 230                 235                 240
 Gln Val Leu Lys Val Ala Cys Ser Asn Thr Leu Leu Asn Asn Ile Val
                 245                 250                 255    
 Leu Tyr Val Ala Thr Ala Leu Leu Gly Val Phe Pro Val Ala Gly Ile
             260                 265                 270        
 Leu Phe Ser Tyr Ser Gln Ile Val Ser Ser Leu Met Gly Met Ser Ser
         275                 280                 285            
 Thr Lys Gly Lys Tyr Lys Ala Phe Ser Thr Cys Gly Ser His Leu Cys
     290                 295                 300                
 Val Val Ser Leu Phe Tyr Gly Thr Gly Leu Gly Val Tyr Leu Ser Ser
 305                 310                 315                 320
 Ala Val Thr His Ser Ser Gln Ser Ser Ser Thr Ala Ser Val Met Tyr
                 325                 330                 335    
 Ala Met Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn
             340                 345                 350        
 Lys Asp Val Lys Gly Ala Leu Glu Arg Leu Leu Ser Arg Ala Asp Ser
         355                 360                 365            
 Cys Leu Leu Arg Cys Pro Ser Tyr Thr Glu Pro Gln Asn Leu Thr Gly
     370                 375                 380                
 Val Ser Glu Phe Leu Leu Leu Gly Leu Ser Glu Asp Pro Glu Leu Gln
 385                 390                 395                 400
 Pro Val Leu Ala Gly Leu Phe Leu Ser Met Tyr Leu Val Thr Val Leu
                 405                 410                 415    
 Gly Asn Leu Leu Ile Ile Leu Ala Val Ser Ser Asp Ser His Leu His
             420                 425                 430        
 Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Leu Ala Asp Ile Gly
         435                 440                 445            
 Phe Thr Ser Thr Thr Val Pro Lys Met Ile Val Asp Met Gln Thr His
     450                 455                 460                
 Ser Arg Val Ile Ser Tyr Glu Gly Cys Leu Thr Gln Met Ser Phe Phe
 465                 470                 475                 480
 Val Leu Phe Ala Cys Met Asp Asp Met Leu Leu Ser Val Met Ala Tyr
                 485                 490                 495    
 Asp Arg Phe Val Ala Ile Cys His Pro Leu His Tyr Arg Ile Ile Met
             500                 505                 510        
 Asn Pro Arg Leu Cys Gly Phe Leu Ile Leu Leu Ser Phe Phe Ile Ser
         515                 520                 525            
 Leu Leu Asp Ser Gln Leu His Asn Leu Ile Met Leu Gln Leu Thr Cys
     530                 535                 540                
 Phe Lys Asp Val Asp Ile Ser Asn Phe Phe Cys Asp Pro Ser Gln Leu
 545                 550                 555                 560
 Leu His Leu Arg Cys Ser Asp Thr Phe Ile Asn Glu Met Val Ile Tyr
                 565                 570                 575    
 Phe Met Gly Ala Ile Phe Gly Cys Leu Pro Ile Ser Gly Ile Leu Phe
             580                 585                 590        
 Ser Tyr Tyr Lys Ile Val Ser Pro Ile Leu Arg Val Pro Thr Ser Asp
         595                 600                 605            
 Gly Lys Tyr Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val
     610                 615                 620                
 Cys Leu Phe Tyr Gly Thr Gly Leu Val Gly Tyr Leu Ser Ser Ala Val
 625                 630                 635                 640
 Leu Pro Ser Pro Arg Lys Ser Met Val Ala Ser Val Met Tyr Thr Val
                 645                 650                 655    
 Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp
             660                 665                 670        
 Ile Gln Ser Ala Leu Cys Arg Leu His Gly Arg Ile Ile Lys Ser His
         675                 680                 685            
 His Leu His Pro Phe Cys Tyr Met Gly
     690                 695        



      <210> 2348
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 2348
 Gln Cys Thr Gln Lys Ala Ala Glu Gly Tyr Thr Gln Phe Tyr Tyr Val
   1               5                  10                  15    
 Asp Val Leu Asp Gly Lys Leu Ala Cys Val Asn Lys Cys Thr Lys Gly
              20                  25                  30        
 Thr Lys Ser Gln Met Asn Cys Asn Leu Gly Thr Cys Gln Leu Gln Arg
          35                  40                  45            
 Ser Gly Pro Arg Cys Leu Cys Pro Asn Thr Asn Thr His Trp Tyr Trp
      50                  55                  60                
 Gly Glu Thr Cys Glu Phe Asn Ile Ala Lys Ser Leu Val Tyr Gly Ile
  65                  70                  75                  80
 Val Gly Ala Val Met Ala Val Leu Leu Leu Ala Leu Ile Ile Leu Ile
                  85                  90                  95    
 Ile Leu Phe Ser Leu Ser Gln Arg Lys Arg His Arg Pro Glu Ser Glu
             100                 105                 110        
 Gly Glu Ala Asp Phe Gly Leu Glu Asn Ala Thr Asn Asn Phe Gly Pro
         115                 120                 125            
 Thr Leu Glu Thr Val Asp Ser Gly Thr Glu Leu His Ile Gln Arg Pro
     130                 135                 140                
 Glu Met Val Ala Ser Thr Val
 145                 150    



      <210> 2349
      <211> 120
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(120)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2349
 Met Ala Leu Thr Gly Tyr Ser Trp Leu Leu Leu Ser Ala Thr Phe Leu
   1               5                  10                  15    
 Asn Val Gly Ala Glu Ile Ser Ile Thr Leu Glu Pro Ala Gln Pro Ser
              20                  25                  30        
 Glu Gly Asp Asn Val Thr Leu Val Val His Gly Leu Ser Gly Glu Leu
          35                  40                  45            
 Leu Ala Tyr Ser Trp Tyr Ala Gly Pro Thr Leu Ser Val Ser Tyr Leu
      50                  55                  60                
 Val Ala Ser Tyr Ile Val Ser Thr Gly Asp Glu Thr Pro Gly Pro Ala
  65                  70                  75                  80
 His Thr Xaa Arg Glu Ala Val Arg Pro Asp Gly Ser Leu Asp Ile Gln
                  85                  90                  95    
 Gly Ile Leu Pro Arg His Ser Ser Thr Tyr Ile Leu Gln Thr Phe Asn
             100                 105                 110        
 Arg Gln Leu Gln Thr Glu Val Gly
         115                 120



      <210> 2350
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 2350
 Arg Gly Tyr Asn Pro Asn Val Asn Ala Gly Ile Ile Asn Ser Phe Ala
   1               5                  10                  15    
 Thr Ala Ala Phe Arg Phe Gly His Thr Leu Ile Asn Pro Ile Leu Tyr
              20                  25                  30        
 Arg Leu Asn Ala Thr Leu Gly Glu Ile Ser Glu Gly His Leu Pro Phe
          35                  40                  45            
 His Lys Ala Leu Phe Ser Pro Ser Arg Ile Ile Lys Glu Gly Gly Ile
      50                  55                  60                
 Asp Pro Val Leu Arg Gly Leu Phe Gly Val Ala Ala Lys Trp Arg Ala
  65                  70                  75                  80
 Pro Ser Tyr Leu Leu Ser Pro Glu Leu Thr Gln Arg Leu Phe Ser Ala
                  85                  90                  95    
 Ala Tyr Ser Ala Ala Val Asp Ser Ala Ala Thr Ile Ile Gln Arg Gly
             100                 105                 110        
 Arg Asp His Gly Ile Pro Pro Tyr Val Asp Phe Arg Val Phe Cys Asn
         115                 120                 125            
 Leu Thr Ser Val Lys Asn Phe Glu Asp Leu Gln Asn Glu Ile Lys Asp
     130                 135                 140                
 Ser Glu Ile Arg Gln Lys Leu Arg Lys Leu Tyr Gly Ser Pro Gly Asp
 145                 150                 155                 160
 Ile Asp Leu Trp Pro Ala Leu Met Val Glu Asp Leu Ile Pro Gly Thr
                 165                 170                 175    
 Arg Val Gly Pro Thr Leu Met Cys Met Leu Ser Thr Gln Phe Gln Arg
             180                 185                 190        
 Leu Arg Asp Gly Asp Arg Phe Trp Tyr Glu Asn Pro Gly Val Phe Thr
         195                 200                 205            
 Pro Ala Gln Leu Thr Gln Leu Lys Gln Ala Ser Leu Ser Arg Val Leu
     210                 215                 220                
 Cys Asp Asn Gly Asp Ser Ile Gln Gln Val Gln Ala Asp Val Phe Arg
 225                 230                 235                 240
 Lys Arg Gln Glu Tyr Pro Gln Asp Tyr Leu Asn Cys Lys Arg Glu Ser
                 245                 250                 255    
 Pro Asn Val Asp Pro Ala Lys Cys
             260                



      <210> 2351
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 2351
 Arg Gly Tyr Asn Pro Asn Val Asn Ala Gly Ile Ile Asn Ser Phe Ala
   1               5                  10                  15    
 Thr Ala Ala Phe Arg Phe Gly His Thr Leu Ile Asn Pro Ile Leu Tyr
              20                  25                  30        
 Arg Leu Asn Ala Thr Leu Gly Glu Ile Ser Glu Gly His Leu Pro Phe
          35                  40                  45            
 His Lys Ala Leu Phe Ser Pro Ser Arg Ile Ile Lys Glu Gly Gly Ile
      50                  55                  60                
 Asp Pro Val Leu Arg Gly Leu Phe Gly Val Ala Ala Lys Trp Arg Ala
  65                  70                  75                  80
 Pro Ser Tyr Leu Leu Ser Pro Glu Leu Thr Gln Arg Leu Phe Ser Ala
                  85                  90                  95    
 Ala Tyr Ser Ala Ala Val Asp Ser Ala Ala Thr Ile Ile Gln Arg Gly
             100                 105                 110        
 Arg Asp His Gly Ile Pro Pro Tyr Val Asp Phe Arg Val Phe Cys Asn
         115                 120                 125            
 Leu Thr Ser Val Lys Asn Phe Glu Asp Leu Gln Asn Glu Ile Lys Asp
     130                 135                 140                
 Ser Glu Ile Arg Gln Lys Leu Arg Lys Leu Tyr Gly Ser Pro Gly Asp
 145                 150                 155                 160
 Ile Asp Leu Trp Pro Ala Leu Met Val Glu Asp Leu Ile Pro Gly Thr
                 165                 170                 175    
 Arg Val Gly Pro Thr Leu Met Cys Met Leu Ser Thr Gln Phe Gln Arg
             180                 185                 190        
 Leu Arg Asp Gly Asp Arg Phe Trp Tyr Glu Asn Pro Gly Val Phe Thr
         195                 200                 205            
 Pro Ala Gln Leu Thr Gln Leu Lys Gln Ala Ser Leu Ser Arg Val Leu
     210                 215                 220                
 Cys Asp Asn Gly Asp Ser Ile Gln Gln Val Gln Ala Asp Val Phe Arg
 225                 230                 235                 240
 Lys Arg Gln Glu Tyr Pro Gln Asp Tyr Leu Asn Cys Lys Arg Glu Ser
                 245                 250                 255    
 Pro Asn Val Asp Pro Ala Lys Cys
             260                



      <210> 2352
      <211> 223
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(223)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2352
 Asn Phe Leu Pro Arg Arg Leu Leu Leu Thr Gly Pro Pro Gln Val Gly
   1               5                  10                  15    
 Lys Thr Gly Ser Tyr Leu Gln Phe Leu Arg Ile Leu Phe Arg Met Leu
              20                  25                  30        
 Ile Arg Leu Leu Glu Val Asp Val Tyr Asp Glu Glu Glu Ile Asn Thr
          35                  40                  45            
 Asp His Asn Glu Ser Ser Glu Val Ser Gln Ser Glu Gly Glu Pro Trp
      50                  55                  60                
 Pro Asp Ile Glu Ser Phe Ser Lys Met Pro Phe Asp Val Ser Val His
  65                  70                  75                  80
 Asp Pro Lys Tyr Ser Leu Met Ser Leu Val Tyr Thr Glu Lys Leu Ala
                  85                  90                  95    
 Gly Val Lys Gln Glu Val Ile Lys Glu Ser Lys Val Glu Glu Pro Arg
             100                 105                 110        
 Lys Arg Glu Thr Val Ser Ile Met Leu Thr Lys Tyr Ala Ala Tyr Asn
         115                 120                 125            
 Thr Phe His His Cys Glu Gln Cys Arg Gln Tyr Met Asp Phe Thr Ser
     130                 135                 140                
 Ala Ser Gln Met Ser Asp Ser Thr Leu His Ala Phe Thr Phe Ser Ser
 145                 150                 155                 160
 Ser Met Leu Gly Glu Glu Val Gln Leu Tyr Phe Ile Ile Pro Lys Ser
                 165                 170                 175    
 Lys Glu Ser His Phe Val Phe Ser Lys Gln Gly Lys His Leu Glu Ser
             180                 185                 190        
 Met Arg Leu Pro Leu Val Ser Asp Lys Asn Leu Asn Ala Val Lys Ser
         195                 200                 205            
 Pro Ile Phe Thr Pro Ser Ser Gly Xaa His Glu His Gly His Val
     210                 215                 220            



      <210> 2353
      <211> 268
      <212> PRT
      <213> Homo sapiens


      <400> 2353
 Arg Glu Leu His Lys Glu Val Glu Val Ala Lys Arg Asn Leu Ala Gln
   1               5                  10                  15    
 Gln Lys Ile Ile Ser Glu Met Glu Ser Lys Leu Val Glu Gln Gln Leu
              20                  25                  30        
 Ala Glu Glu Asn Lys Leu Leu Lys Glu Gln Glu Asn Met Lys Glu Leu
          35                  40                  45            
 Val Val Asn Leu Leu Arg Met Thr Gln Ile Lys Ile Asp Glu Lys Glu
      50                  55                  60                
 Gln Lys Ser Lys Asp Phe Leu Lys Ala Gln Gln Lys Tyr Thr Asn Ile
  65                  70                  75                  80
 Val Lys Glu Met Lys Ala Lys Asp Leu Glu Ile Arg Ile His Lys Lys
                  85                  90                  95    
 Lys Lys Cys Glu Ile Tyr Arg Arg Leu Arg Glu Phe Ala Lys Leu Tyr
             100                 105                 110        
 Asp Thr Ile Arg Asn Glu Arg Asn Lys Phe Val Asn Leu Leu His Lys
         115                 120                 125            
 Ala His Gln Lys Val Asn Glu Ile Lys Glu Arg His Lys Met Ser Leu
     130                 135                 140                
 Asn Glu Leu Glu Ile Leu Arg Asn Ser Ala Val Ser Gln Glu Arg Lys
 145                 150                 155                 160
 Leu Gln Asn Ser Met Leu Lys His Ala Asn Asn Val Thr Ile Arg Glu
                 165                 170                 175    
 Ser Met Gln Asn Asp Val Arg Lys Ile Val Ser Lys Leu Gln Glu Met
             180                 185                 190        
 Lys Glu Lys Lys Glu Ala Gln Leu Asn Asn Ile Asp Arg Leu Ala Asn
         195                 200                 205            
 Thr Ile Thr Met Ile Glu Glu Glu Met Val Gln Leu Arg Lys Arg Tyr
     210                 215                 220                
 Glu Lys Ala Val Gln His Arg Asn Glu Arg Arg Gly Leu Ser Pro Gly
 225                 230                 235                 240
 Met Ile Thr Lys Asp Arg Phe Leu Pro Val Tyr Gly Glu Ile Thr Thr
                 245                 250                 255    
 Arg Asn Ile Gln Leu Glu Lys Lys Leu Met Gly Leu
             260                 265            



      <210> 2354
      <211> 289
      <212> PRT
      <213> Homo sapiens


      <400> 2354
 Met Gly Leu Cys Val Pro Phe Ala Val Thr Thr Ser Phe Leu Ser Leu
   1               5                  10                  15    
 Gly Leu Glu Trp Asp Leu Asn Val Arg Leu His Gly Gln His Leu Val
              20                  25                  30        
 Gln Gln Leu Val Leu Arg Thr Val Arg Gly Tyr Leu Glu Thr Pro Gln
          35                  40                  45            
 Pro Glu Lys Ala Leu Ala Leu Ser Phe His Gly Trp Ser Gly Thr Gly
      50                  55                  60                
 Lys Asn Phe Val Ala Arg Met Leu Val Glu Asn Leu Tyr Arg Asp Gly
  65                  70                  75                  80
 Leu Met Ser Asp Cys Val Arg Met Phe Ile Ala Thr Phe His Phe Pro
                  85                  90                  95    
 His Pro Lys Tyr Val Asp Leu Tyr Lys Glu Gln Leu Met Ser Gln Ile
             100                 105                 110        
 Arg Glu Thr Gln Gln Leu Cys His Gln Thr Leu Phe Ile Phe Asp Glu
         115                 120                 125            
 Ala Glu Lys Leu His Pro Gly Leu Leu Glu Val Leu Gly Pro His Leu
     130                 135                 140                
 Glu Arg Arg Ala Pro Glu Gly His Arg Ala Glu Ser Pro Trp Thr Ile
 145                 150                 155                 160
 Phe Leu Phe Leu Ser Asn Leu Arg Gly Asp Ile Ile Asn Glu Val Val
                 165                 170                 175    
 Leu Lys Leu Leu Lys Ala Gly Trp Ser Arg Glu Glu Ile Thr Met Glu
             180                 185                 190        
 His Leu Glu Pro His Leu Gln Ala Glu Ile Val Glu Thr Ile Asp Asn
         195                 200                 205            
 Gly Phe Gly His Ser Arg Leu Val Lys Glu Asn Leu Ile Asp Tyr Phe
     210                 215                 220                
 Ile Pro Phe Leu Pro Leu Glu Tyr Arg His Val Arg Leu Cys Ala Arg
 225                 230                 235                 240
 Asp Ala Phe Leu Ser Gln Glu Leu Leu Tyr Lys Glu Glu Thr Leu Asp
                 245                 250                 255    
 Glu Ile Ala Gln Met Met Val Tyr Val Pro Lys Glu Glu Gln Leu Phe
             260                 265                 270        
 Ser Ser Gln Gly Cys Lys Ser Ile Ser Gln Arg Ile Asn Tyr Phe Leu
         275                 280                 285            
 Ser
    



      <210> 2355
      <211> 240
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(240)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2355
 Xaa Arg Ala Met Asn Phe Ser Ile Cys Phe Leu Glu Ile Gly Ser Ile
   1               5                  10                  15    
 Xaa Thr Gly Arg Tyr Cys Lys Thr Val Leu Cys Lys Leu Arg Ala Val
              20                  25                  30        
 Leu Xaa Ser Phe Arg Val Leu Asn Ile Thr Lys Ala Tyr Leu Val Leu
          35                  40                  45            
 Phe Ser Ser Leu Tyr Lys Asn Leu Ile Cys Ser Ser Val Arg Ser Val
      50                  55                  60                
 Pro Leu Lys Lys Phe Leu Lys Ser Leu Ser Ser Ile Leu Arg Asp Arg
  65                  70                  75                  80
 Phe Phe Lys Xaa Thr Xaa Asn Pro Arg Gly Glu Arg Glu Arg Val Leu
                  85                  90                  95    
 Leu Gly Asp Phe Glu Xaa Asp Arg Phe Arg Lys Cys Leu Ser Leu Ile
             100                 105                 110        
 Pro Leu Gly Gly Glu Cys Ser Ser Asp Leu Leu Arg Thr Ser Pro Ser
         115                 120                 125            
 Leu Thr Ala Leu Pro Pro Asn Ser Ile His Cys Cys Ser Asp Pro Cys
     130                 135                 140                
 Ile Thr Ser Ile Asn Leu Glu Pro Ile Lys Leu Leu Xaa His Leu Arg
 145                 150                 155                 160
 Pro Pro Glu Ala Ser Thr His Glu Ala Asn Phe Thr Met Ala Ser Pro
                 165                 170                 175    
 Leu Phe Arg Pro Ser Xaa Cys Phe Lys Lys Ile Thr Pro Ser Thr His
             180                 185                 190        
 Lys Pro Glu Lys Lys Thr Arg Thr Ser Ser Ser Phe Thr Arg Xaa Gly
         195                 200                 205            
 Lys Pro Arg Arg Asn Lys Xaa Gly Phe Ser Ala Phe Asn Gly Leu Val
     210                 215                 220                
 Phe Leu Gly Leu Lys Leu Pro Cys Pro Val Pro Leu Val Xaa Asn Pro
 225                 230                 235                 240





      <210> 2356
      <211> 270
      <212> PRT
      <213> Homo sapiens


      <400> 2356
 Gly Arg Thr Ser Ser Gly Lys Ala Gly Met Trp Lys Pro Gly Ala Glu
   1               5                  10                  15    
 Ser Trp Pro Leu His Thr Gly Ala Ala Gln Val Met Trp Phe Glu Lys
              20                  25                  30        
 Leu Tyr Ala Gly Leu Gln Cys Val Glu Lys Tyr Leu Ile Tyr Pro Ala
          35                  40                  45            
 Val Val Leu Asn Ala Leu Thr Val Asp Ala His Thr Val Val Ser His
      50                  55                  60                
 Pro Asp Lys Tyr Cys Phe Tyr Cys Arg Ala Leu Leu Met Thr Val Ala
  65                  70                  75                  80
 Gly Leu Lys Leu Leu Arg Ser Ala Phe Cys Cys Pro Pro Gln Gln Tyr
                  85                  90                  95    
 Leu Thr Leu Ala Phe Thr Val Leu Leu Phe His Phe Asp Tyr Pro Arg
             100                 105                 110        
 Leu Ser Gln Gly Phe Leu Leu Asp Tyr Phe Leu Met Ser Leu Leu Cys
         115                 120                 125            
 Ser Lys Leu Trp Asp Leu Leu Tyr Lys Leu Arg Phe Val Leu Thr Tyr
     130                 135                 140                
 Ile Ala Pro Trp Gln Ile Thr Trp Gly Ser Ala Phe His Ala Phe Ala
 145                 150                 155                 160
 Gln Pro Phe Ala Val Pro His Ser Ala Met Leu Phe Val Gln Ala Leu
                 165                 170                 175    
 Leu Ser Gly Leu Phe Ser Thr Pro Leu Asn Pro Leu Leu Gly Ser Ala
             180                 185                 190        
 Val Phe Ile Met Ser Tyr Ala Arg Pro Leu Lys Phe Trp Glu Arg Asp
         195                 200                 205            
 Tyr Asn Thr Lys Arg Val Asp His Ser Asn Thr Arg Leu Val Thr Gln
     210                 215                 220                
 Leu Asp Arg Asn Pro Gly Ala Asp Asp Asn Asn Leu Asn Ser Ile Phe
 225                 230                 235                 240
 Tyr Glu His Leu Thr Arg Ser Leu Gln His Thr Leu Cys Gly Asp Leu
                 245                 250                 255    
 Val Leu Gly Arg Trp Gly Asn Tyr Gly Pro Gly Asp Cys Phe
             260                 265                 270



      <210> 2357
      <211> 270
      <212> PRT
      <213> Homo sapiens


      <400> 2357
 Gly Arg Thr Ser Ser Gly Lys Ala Gly Met Trp Lys Pro Gly Ala Glu
   1               5                  10                  15    
 Ser Trp Pro Leu His Thr Gly Ala Ala Gln Val Met Trp Phe Glu Lys
              20                  25                  30        
 Leu Tyr Ala Gly Leu Gln Cys Val Glu Lys Tyr Leu Ile Tyr Pro Ala
          35                  40                  45            
 Val Val Leu Asn Ala Leu Thr Val Asp Ala His Thr Val Val Ser His
      50                  55                  60                
 Pro Asp Lys Tyr Cys Phe Tyr Cys Arg Ala Leu Leu Met Thr Val Ala
  65                  70                  75                  80
 Gly Leu Lys Leu Leu Arg Ser Ala Phe Cys Cys Pro Pro Gln Gln Tyr
                  85                  90                  95    
 Leu Thr Leu Ala Phe Thr Val Leu Leu Phe His Phe Asp Tyr Pro Arg
             100                 105                 110        
 Leu Ser Gln Gly Phe Leu Leu Asp Tyr Phe Leu Met Ser Leu Leu Cys
         115                 120                 125            
 Ser Lys Leu Trp Asp Leu Leu Tyr Lys Leu Arg Phe Val Leu Thr Tyr
     130                 135                 140                
 Ile Ala Pro Trp Gln Ile Thr Trp Gly Ser Ala Phe His Ala Phe Ala
 145                 150                 155                 160
 Gln Pro Phe Ala Val Pro His Ser Ala Met Leu Phe Val Gln Ala Leu
                 165                 170                 175    
 Leu Ser Gly Leu Phe Ser Thr Pro Leu Asn Pro Leu Leu Gly Ser Ala
             180                 185                 190        
 Val Phe Ile Met Ser Tyr Ala Arg Pro Leu Lys Phe Trp Glu Arg Asp
         195                 200                 205            
 Tyr Asn Thr Lys Arg Val Asp His Ser Asn Thr Arg Leu Val Thr Gln
     210                 215                 220                
 Leu Asp Arg Asn Pro Gly Ala Asp Asp Asn Asn Leu Asn Ser Ile Phe
 225                 230                 235                 240
 Tyr Glu His Leu Thr Arg Ser Leu Gln His Thr Leu Cys Gly Asp Leu
                 245                 250                 255    
 Val Leu Gly Arg Trp Gly Asn Tyr Gly Pro Gly Asp Cys Phe
             260                 265                 270



      <210> 2358
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 2358
 Ser Thr Ala Thr Trp Ala Gly Val Gln Trp Cys Asn Leu Ser Ser Leu
   1               5                  10                  15    
 Gln Pro Leu Pro Ser Gly Phe Lys Pro Phe Ser Cys Leu Ser Leu Pro
              20                  25                  30        
 Gly Ser Trp Asp His Arg His Leu Pro Pro Cys Pro Ala Asn Phe Leu
          35                  40                  45            
 Tyr Cys Phe Phe Leu Val Glu Met Gly Phe His Tyr Val Gly Gln Ala
      50                  55                  60                
 Gly Leu Lys Leu Leu Thr Ser Gly Asp Leu Cys Ala Ser Ala Pro Gln
  65                  70                  75                  80
 Ser Ala Gly Ser Thr Gly Val Asn His Arg Val Arg Leu Gly Leu Leu
                  85                  90                  95    
 Ile Tyr Ile Pro
             100



      <210> 2359
      <211> 348
      <212> PRT
      <213> Homo sapiens


      <400> 2359
 Pro Glu Pro His Ala Val Gln Cys Ala Glu Leu Arg His Gln Gln Pro
   1               5                  10                  15    
 Arg Asp Pro Gln Arg Leu Gln Gln Asp Gly Ser Ala Asp Ala Pro Ala
              20                  25                  30        
 Glu Arg Lys Pro His Cys Gly Gly Glu Arg Ala His Gly Ser Gly Phe
          35                  40                  45            
 Leu Ala Met Leu Leu Val Leu Gly Leu Cys Gly Ala Ala Tyr Arg Pro
      50                  55                  60                
 Thr Glu Glu Ile Asp Leu Arg Ser Val Gly Trp Gly Asn Ile Phe Gln
  65                  70                  75                  80
 Leu Pro Phe Lys His Val Arg Asp Tyr Arg Leu Arg His Leu Val Pro
                  85                  90                  95    
 Phe Phe Ile Tyr Ser Gly Phe Glu Val Leu Phe Ala Cys Thr Gly Ile
             100                 105                 110        
 Ala Leu Gly Tyr Gly Val Cys Ser Val Gly Leu Glu Arg Leu Ala Tyr
         115                 120                 125            
 Leu Leu Val Ala Tyr Ser Leu Gly Ala Ser Ala Ala Ser Leu Leu Gly
     130                 135                 140                
 Leu Leu Gly Leu Trp Leu Pro Arg Pro Val Pro Leu Val Ala Gly Ala
 145                 150                 155                 160
 Gly Val His Leu Leu Leu Thr Phe Ile Leu Phe Phe Trp Ala Pro Val
                 165                 170                 175    
 Pro Arg Val Leu Gln His Ser Trp Ile Leu Tyr Val Ala Ala Ala Leu
             180                 185                 190        
 Trp Gly Val Gly Ser Ala Leu Asn Lys Thr Gly Leu Ser Thr Leu Leu
         195                 200                 205            
 Gly Ile Leu Tyr Glu Asp Lys Glu Arg Gln Asp Phe Ile Phe Thr Ile
     210                 215                 220                
 Tyr His Trp Trp Gln Ala Val Ala Ile Phe Thr Val Tyr Leu Gly Ser
 225                 230                 235                 240
 Ser Leu His Met Lys Ala Lys Leu Glu Val Leu Leu Val Thr Leu Val
                 245                 250                 255    
 Ala Ala Ala Val Ser Tyr Leu Arg Met Glu Gln Lys Leu Arg Arg Gly
             260                 265                 270        
 Val Ala Pro Arg Gln Pro Arg Ile Pro Arg Pro Gln His Lys Val Arg
         275                 280                 285            
 Gly Tyr Arg Tyr Leu Gln Ala His Asn Ser Asp Glu Ser Asp Pro Glu
     290                 295                 300                
 Gly Glu His Ala Asp Ala Ala Gln Glu Glu Ala Pro Pro Ala Gly Pro
 305                 310                 315                 320
 Arg Pro Gly Pro Glu Pro Ala Gly Leu Gly Arg Arg Pro Cys Pro Tyr
                 325                 330                 335    
 Glu Gln Ala Gln Gly Gly Asp Gly Pro Glu Glu Gln
             340                 345            



      <210> 2360
      <211> 465
      <212> PRT
      <213> Homo sapiens


      <400> 2360
 Leu Arg Ala Gly Glu Asp Met Ala Ala Ser Ala Ser Ala Ala Ala Gly
   1               5                  10                  15    
 Glu Glu Asp Trp Val Leu Pro Ser Glu Val Glu Val Leu Glu Ser Ile
              20                  25                  30        
 Tyr Leu Asp Glu Leu Gln Val Ile Lys Gly Asn Gly Arg Thr Ser Pro
          35                  40                  45            
 Trp Glu Ile Tyr Ile Thr Leu His Pro Ala Thr Ala Glu Asp Gln Asp
      50                  55                  60                
 Ser Gln Tyr Val Cys Phe Thr Leu Val Leu Gln Val Pro Ala Glu Tyr
  65                  70                  75                  80
 Pro His Glu Val Pro Gln Ile Ser Ile Arg Asn Pro Arg Gly Leu Ser
                  85                  90                  95    
 Asp Glu Gln Ile His Thr Ile Leu Gln Val Leu Gly His Val Ala Lys
             100                 105                 110        
 Ala Gly Leu Gly Thr Ala Met Leu Tyr Glu Leu Ile Glu Lys Gly Lys
         115                 120                 125            
 Glu Ile Leu Thr Asp Asn Asn Ile Pro His Gly Gln Cys Val Ile Cys
     130                 135                 140                
 Leu Tyr Gly Phe Gln Glu Lys Glu Ala Phe Thr Lys Thr Pro Cys Tyr
 145                 150                 155                 160
 His Tyr Phe His Cys His Cys Leu Ala Arg Tyr Ile Gln His Met Glu
                 165                 170                 175    
 Gln Glu Leu Lys Ala Gln Gly Gln Glu Gln Glu Gln Glu Arg Gln His
             180                 185                 190        
 Ala Thr Thr Lys Gln Lys Ala Val Gly Val Gln Cys Pro Val Cys Arg
         195                 200                 205            
 Glu Pro Leu Val Tyr Asp Leu Ala Ser Leu Lys Ala Ala Pro Glu Pro
     210                 215                 220                
 Gln Gln Pro Met Glu Leu Tyr Gln Pro Ser Ala Glu Ser Leu Arg Gln
 225                 230                 235                 240
 Gln Glu Glu Arg Lys Arg Leu Tyr Gln Arg Gln Gln Glu Arg Gly Gly
                 245                 250                 255    
 Ile Ile Asp Leu Glu Ala Glu Arg Asn Arg Tyr Phe Ile Ser Leu Gln
             260                 265                 270        
 Gln Pro Pro Ala Pro Ala Glu Pro Glu Ser Ala Val Asp Val Ser Lys
         275                 280                 285            
 Gly Ser Gln Pro Pro Ser Thr Leu Ala Ala Glu Leu Ser Thr Ser Pro
     290                 295                 300                
 Ala Val Gln Ser Thr Leu Pro Pro Pro Leu Pro Val Ala Thr Gln His
 305                 310                 315                 320
 Ile Cys Glu Lys Ile Pro Gly Thr Arg Ser Asn Gln Gln Arg Leu Gly
                 325                 330                 335    
 Glu Thr Gln Lys Ala Met Leu Asp Pro Pro Lys Pro Ser Arg Gly Pro
             340                 345                 350        
 Trp Arg Gln Pro Glu Arg Arg His Pro Lys Gly Gly Glu Cys His Ala
         355                 360                 365            
 Pro Lys Gly Thr Arg Asp Thr Gln Glu Leu Pro Pro Pro Glu Gly Pro
     370                 375                 380                
 Leu Lys Glu Pro Met Asp Leu Lys Pro Glu Pro His Ser Gln Gly Val
 385                 390                 395                 400
 Glu Gly Pro Pro Gln Glu Lys Gly Pro Gly Ser Trp Gln Gly Pro Pro
                 405                 410                 415    
 Pro Arg Arg Thr Arg Asp Cys Val Arg Trp Glu Arg Ser Lys Gly Arg
             420                 425                 430        
 Thr Pro Gly Ser Ser Tyr Pro Arg Leu Pro Arg Gly Gln Gly Ala Tyr
         435                 440                 445            
 Arg Pro Gly Thr Arg Arg Glu Ser Leu Gly Leu Glu Ser Lys Asp Gly
     450                 455                 460                
 Ser
 465



      <210> 2361
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 2361
 Ser Glu Gln Glu Pro Leu Leu Gly Asp Thr Pro Gly Ser Arg Glu Trp
   1               5                  10                  15    
 Asp Ile Leu Glu Thr Glu Glu His Tyr Lys Ser Arg Trp Arg Ser Ile
              20                  25                  30        
 Arg Ile Leu Tyr Leu Thr Met Phe Leu Ser Ser Val Gly Phe Ser Val
          35                  40                  45            
 Val Met Met Ser Ile Trp Pro Tyr Leu Gln Lys Ile Asp Pro Thr Ala
      50                  55                  60                
 Asp Thr Ser Phe Leu Gly Trp Val Ile Ala Ser Tyr Ser Leu Gly Gln
  65                  70                  75                  80
 Met Val Ala Ser Pro Ile Phe Gly Leu Trp Ser Asn Tyr Arg Pro Arg
                  85                  90                  95    
 Lys Glu Pro Leu Ile Val Ser Ile Leu Ile Ser Val Ala Ala Asn Cys
             100                 105                 110        
 Leu Tyr Ala Tyr Leu His Ile Pro Ala Ser His Asn Lys Tyr Tyr Met
         115                 120                 125            
 Leu Val Ala Arg Gly Leu Leu Gly Ile Gly
     130                 135            



      <210> 2362
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 2362
 Met Thr Ala Glu Phe Leu Ser Leu Leu Cys Leu Gly Leu Cys Leu Gly
   1               5                  10                  15    
 Tyr Glu Asp Glu Lys Lys Asn Glu Lys Pro Pro Lys Pro Ser Leu His
              20                  25                  30        
 Ala Trp Pro Ser Ser Val Val Glu Ala Glu Ser Asn Val Thr Leu Lys
          35                  40                  45            
 Cys Gln Ala His Ser Gln Asn Val Thr Phe Val Leu Arg Lys Val Asn
      50                  55                  60                
 Asp Ser Gly Tyr Lys Gln Glu Gln Ser Ser Ala Glu Asn Glu Ala Glu
  65                  70                  75                  80
 Phe Pro Phe Thr Asp Leu Lys Pro Lys Asp Ala Gly Arg Tyr Phe Cys
                  85                  90                  95    
 Ala Tyr Lys Thr Thr Ala Ser His Glu Trp Ser Glu Ser Ser Glu His
             100                 105                 110        
 Leu Gln Leu Val Val Thr Asp Lys His Asp Glu Leu Glu Ala Pro Ser
         115                 120                 125            
 Met Lys Thr Asp Thr Arg Thr Ile Phe Val Ala Ile Phe Ser Cys Ile
     130                 135                 140                
 Ser Ile Leu Leu Leu Phe Leu Ser Val Phe Ile Ile Tyr Arg Cys Ser
 145                 150                 155                 160
 Gln His Ser Ser Ser Ser Glu Glu Ser Thr Lys Arg Thr Ser His Ser
                 165                 170                 175    
 Lys Leu Pro Glu Gln Glu Ala Ala Glu Ala Asp Leu Ser Asn Met Glu
             180                 185                 190        
 Arg Val Ser Leu Ser Thr Ala Asp Pro Gln Gly Val Thr Tyr Ala Glu
         195                 200                 205            
 Leu Ser Thr Ser Ala Leu Ser Glu Ala Ala Ser Asp Thr Thr Gln Glu
     210                 215                 220                
 Pro Pro Gly Ser His Glu Tyr Ala Ala Leu Lys Val
 225                 230                 235    



      <210> 2363
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 2363
 Met Thr Ala Glu Phe Leu Ser Leu Leu Cys Leu Gly Leu Cys Leu Gly
   1               5                  10                  15    
 Tyr Glu Asp Glu Lys Lys Asn Glu Lys Pro Pro Lys Pro Ser Leu His
              20                  25                  30        
 Ala Trp Pro Ser Ser Val Val Glu Ala Glu Ser Asn Val Thr Leu Lys
          35                  40                  45            
 Cys Gln Ala His Ser Gln Asn Val Thr Phe Val Leu Arg Lys Val Asn
      50                  55                  60                
 Asp Ser Gly Tyr Lys Gln Glu Gln Ser Ser Ala Glu Asn Glu Ala Glu
  65                  70                  75                  80
 Phe Pro Phe Thr Asp Leu Lys Pro Lys Asp Ala Gly Arg Tyr Phe Cys
                  85                  90                  95    
 Ala Tyr Lys Thr Thr Ala Ser His Glu Trp Ser Glu Ser Ser Glu His
             100                 105                 110        
 Leu Gln Leu Val Val Thr Asp Lys His Asp Glu Leu Glu Ala Pro Ser
         115                 120                 125            
 Met Lys Thr Asp Thr Arg Thr Ile Phe Val Ala Ile Phe Ser Cys Ile
     130                 135                 140                
 Ser Ile Leu Leu Leu Phe Leu Ser Val Phe Ile Ile Tyr Arg Cys Ser
 145                 150                 155                 160
 Gln His Ser Ser Ser Ser Glu Glu Ser Thr Lys Arg Thr Ser His Ser
                 165                 170                 175    
 Lys Leu Pro Glu Gln Glu Ala Ala Glu Ala Asp Leu Ser Asn Met Glu
             180                 185                 190        
 Arg Val Ser Leu Ser Thr Ala Asp Pro Gln Gly Val Thr Tyr Ala Glu
         195                 200                 205            
 Leu Ser Thr Ser Ala Leu Ser Glu Ala Ala Ser Asp Thr Thr Gln Glu
     210                 215                 220                
 Pro Pro Gly Ser His Glu Tyr Ala Ala Leu Lys Val
 225                 230                 235    



      <210> 2364
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 2364
 Ala Ala Ala Trp Gly Leu Ala Ala Trp Gly Glu Gly Pro Thr Asp Ala
   1               5                  10                  15    
 Thr Ser Cys Trp Glu Val Gly Ala Gly Gly Pro Gly Asn Ser Arg Pro
              20                  25                  30        
 Asn Gln Thr Val Ser Met Asp Leu Asn Ser Ala Ser Thr Val Val Leu
          35                  40                  45            
 Gln Val Leu Thr Gln Ala Thr Ser Gln Asp Thr Ala Val Leu Lys Pro
      50                  55                  60                
 Ala Glu Glu Gln Leu Lys Gln Trp Glu Thr Gln Pro Gly Phe Tyr Ser
  65                  70                  75                  80
 Val Leu Leu Asn Ile Phe Thr Asn His Thr Leu Asp Ile Asn Val Arg
                  85                  90                  95    
 Trp Leu Ala Val Leu Tyr Phe Lys His Gly Ile Asp Arg
             100                 105                



      <210> 2365
      <211> 913
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(913)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2365
 Cys His Gly Leu Gln His Leu Thr Pro Phe Arg Glu Leu Asn Leu Ser
   1               5                  10                  15    
 Leu Gln Gly Xaa Glu Pro His Xaa Ala Ala Xaa Gln Ala Val Arg Ser
              20                  25                  30        
 Glu Glu Lys Ser Ile Cys Xaa Gly Ser Pro Ser Cys His Leu Val Leu
          35                  40                  45            
 Gly Val Leu Val Pro Val Ala Arg Gln Ser Ser His Ser Ala Gly Pro
      50                  55                  60                
 Ala Gln Ser Ala Phe Arg Xaa Thr Gly Thr Gly Ser Gly Thr Pro Lys
  65                  70                  75                  80
 Ala Ala Glu Gln Ser Gly Tyr Trp Glu Ala Tyr Thr Leu Gly His Gln
                  85                  90                  95    
 His Trp Asn Met Phe Pro Ile Gln Arg Pro Pro Leu Val Met Lys Gly
             100                 105                 110        
 Arg Arg Ile Met Cys Gly Lys Cys Glu Lys Gly Xaa Val Ser Asp Ser
         115                 120                 125            
 Val Thr Gly Gly Arg Ala Val Ala Gly Glu Gln Ala Ser Gln Arg Arg
     130                 135                 140                
 Thr Val Phe Thr Ala Gly Gly Gly Glu Cys Leu Gly Ala Lys Ser Val
 145                 150                 155                 160
 Arg Ala Ser Val Phe Thr Gly Asn Gln Pro Gly Val Met Gly Leu Leu
                 165                 170                 175    
 Asn Gly Lys Arg Gly Gly Cys Phe Glu Ser Gly Tyr Leu Phe Gly Phe
             180                 185                 190        
 Ile Val Ile Gly Lys Ile Gln Ser Leu Glu Ala Lys Val Pro Leu Pro
         195                 200                 205            
 Val Asn Gly Gln Thr Gly Glu Arg Ala Ser Pro Gly Asn Cys Arg Ile
     210                 215                 220                
 His Ile Val Asp Ala Val Cys Xaa Ser Glu His His Xaa Asp His Phe
 225                 230                 235                 240
 Leu Ala Ala Ala Phe Leu Glu Asn Ser Thr Ile Ile Ser Xaa Val Ala
                 245                 250                 255    
 Pro Gly Ser Trp Gln Asp His Ala Val Leu Gln Lys Glu Val Gln Ala
             260                 265                 270        
 Ser Val Arg Cys Arg Gly Phe Glu Ser Val Asp Thr Ala Pro Ala Gly
         275                 280                 285            
 Phe Trp Ala His Ser Pro Pro Gly Leu Gln Gly Glu Pro Thr Thr Thr
     290                 295                 300                
 Ser Val Ser Leu Phe Val Leu Ala Pro Gln Asp Gly Glu Gly Val Pro
 305                 310                 315                 320
 Phe Val Glu Gly Gln Leu Val Thr Val Leu Gly Leu Val Val Pro Gln
                 325                 330                 335    
 Ser Ile Arg His Thr Phe Val His His Thr Gln Leu Phe Leu His Pro
             340                 345                 350        
 Ile Xaa Lys Leu Gly Ala Leu Asp Val Ala Phe Leu His Leu Leu Thr
         355                 360                 365            
 Leu Val Cys Ser Ser Phe Asn Val Ala Tyr Gly Xaa Gly Lys Asn Gly
     370                 375                 380                
 Gly Thr Thr Leu His Gln Leu Phe Ala Glu Val Asn Ala Val Thr Arg
 385                 390                 395                 400
 Gly Ser Ala Val Gln Arg Arg Pro Ser Ile Thr Ile Ser Ser Ile His
                 405                 410                 415    
 Val Asp Thr Lys Ile Gln Gln Glu Leu His Asp Val Met Val Ala Gly
             420                 425                 430        
 Ala Asp Gly Val Val Gln Trp Gly Asp Pro Phe Val Val Gly Leu Ala
         435                 440                 445            
 Gly Ile Phe His Leu Ile Asp Asp Pro Leu His Gln Ile Glu Leu Ser
     450                 455                 460                
 Phe Gln Arg Arg Val Xaa Glu Gln Cys Gln Gly Val Lys Pro Asp Ser
 465                 470                 475                 480
 Gln Pro Val Pro Arg Pro Leu Arg Val Gly Leu Leu Gln Val Gly Pro
                 485                 490                 495    
 Leu Val Arg Gly Gly Gly Arg Arg Val Ala Gly Arg Gly Lys Arg Cys
             500                 505                 510        
 Trp Arg Asp Leu Leu Phe Pro Trp Arg Trp Gly Leu Ser His Arg Thr
         515                 520                 525            
 Arg Asp Leu Leu Arg Gly Gly Asp Arg Gly His Val Val Val Ile Val
     530                 535                 540                
 Leu Cys Arg Leu Gly Ser Leu Val Gly Gly Leu Gly Thr Asp Glu Leu
 545                 550                 555                 560
 Leu Trp Phe Gly Gly Arg Xaa Leu Ile Ile Ile Gly Ile Xaa Xaa Arg
                 565                 570                 575    
 Gly Arg Leu Ser Gly Glu Trp Gly Cys Gly Leu Gly Arg Gly Glu Leu
             580                 585                 590        
 Phe Gln Val Ser Ile Gly Ile Gly Val Ser Ile Val His Ile Gly Gln
         595                 600                 605            
 Gly Asp His Glu Val Leu Gly Gly Ala Gly Leu Val Glu Arg Gly Ala
     610                 615                 620                
 Leu His Ala Thr Gly Gln Gly Val Glu Ala Leu Val Gln Gln Leu Leu
 625                 630                 635                 640
 Asp Val Gly Pro Ala Gly Ala Leu Gly Leu Cys Asp Gly Ala Ala Leu
                 645                 650                 655    
 Phe Gln Gly Pro Gly Arg Val Gly Gln Leu Pro Ala Glu Gly Leu Gln
             660                 665                 670        
 Val Cys Ile Thr Leu Val Ala Gln Trp Arg Met His Asp Gly Arg Glu
         675                 680                 685            
 Leu Gly Gly Ala Glu Trp Pro Trp Gln Ala Leu His Gly Ala Ala Ile
     690                 695                 700                
 Cys Gly Val Gly Gly Ala Ile Leu Leu Lys Ala Leu Ser Gln Tyr Phe
 705                 710                 715                 720
 Leu Lys Gly Gly Xaa Arg Leu Trp Cys Ala Arg Gly Gln Xaa Pro Val
                 725                 730                 735    
 Lys Lys Arg Gln Arg Arg Trp Arg Gly Xaa Thr Arg Arg Xaa Asn Gly
             740                 745                 750        
 Leu Thr Ile His Cys Phe Asn Xaa Leu Ile Xaa Gly Ala Val Cys Cys
         755                 760                 765            
 Arg Leu Val Ile Leu Arg Trp Cys Gly Leu Leu Glu Val His Gly Val
     770                 775                 780                
 Tyr Gly Thr Xaa Ile His Cys Leu Gly Ser Phe Pro Gly Arg Leu Trp
 785                 790                 795                 800
 Pro Xaa Pro Phe Ile Ser Gln Glu Arg Pro Asn Gly His Cys Gln Trp
                 805                 810                 815    
 Glu Phe Arg Leu Ala Val Pro Ser Trp Lys Cys Arg Trp Ser Arg Trp
             820                 825                 830        
 Arg Val Arg Gly Thr Trp Arg Tyr Gly Asn Pro Leu Leu Asn Leu Leu
         835                 840                 845            
 Xaa Gly Ala Trp Leu Gly Gly Ala Ala Cys Gly Gly Gln Gln Gly Gly
     850                 855                 860                
 Pro Leu Ser Thr Trp Gln Ala Cys Thr Gly Pro Gly Gln Ala Ala Phe
 865                 870                 875                 880
 Leu Pro Pro Phe Gln Gly Ala Cys Arg Pro Arg Thr Gln Arg Cys Arg
                 885                 890                 895    
 Thr Trp Val Cys Pro Ile Ala Trp Arg Gln Leu Leu Ala Tyr Thr Arg
             900                 905                 910        
 Asp
    



      <210> 2366
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 2366
 Met Tyr Gly Met Leu Glu Trp Pro Ile Ser Met Tyr Phe Val Ala Phe
   1               5                  10                  15    
 Leu His Cys Phe Leu Cys Ser Gly Gly Asn Leu Gly Asp Ser Phe Gln
              20                  25                  30        
 Ala Leu Pro Glu Leu Cys Ala Asn Cys Ser Ser Ser Pro Arg Val Leu
          35                  40                  45            
 Cys Cys Val Val Met Ser Pro Leu Pro
      50                  55        



      <210> 2367
      <211> 122
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(122)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2367
 Tyr Tyr Gln Ile Ser Ser Leu Pro Ser Ile Val Gly Asn Gly Ile Phe
   1               5                  10                  15    
 Leu Trp Leu Leu Ile Cys Ile Phe Leu Ala Lys Gln Gly Gly Ser Arg
              20                  25                  30        
 Leu Xaa Phe Gln Pro Phe Gly Arg Pro Arg Gly Gly Gly His Leu Arg
          35                  40                  45            
 Ser Gly Val Leu Gly Gln Pro Gly Gln His Gly Glu Thr Pro Ser Phe
      50                  55                  60                
 Phe Tyr Asn Ser Lys Ile Ser Pro Ala Leu Trp Gly Pro Pro Val Ile
  65                  70                  75                  80
 Pro Ser Ala Leu Gly Gly Glu Ala Gly Lys Ser Leu Xaa Pro Arg Arg
                  85                  90                  95    
 Gln Arg Phe Gln Arg Gly Gly Ile Ala Pro Leu Pro Ser Arg Val Arg
             100                 105                 110        
 Gly Arg Ala Lys Leu Phe Leu Lys Lys Lys
         115                 120        



      <210> 2368
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 2368
 Met His Phe Leu Ala Thr Phe Ala Leu Phe Phe Ile Phe Gly Val Phe
   1               5                  10                  15    
 Phe Leu Phe Ala Val Leu Thr Asn Leu Leu Leu Ala Glu Glu Val Asn
              20                  25                  30        
 Ile Arg Gly Gly Asn Phe Leu Gly Ser Phe Leu Val His Thr Leu Phe
          35                  40                  45            
 Leu Asp Gln Val Pro Gly Glu Ile Thr His Asp Ser His Leu Val Leu
      50                  55                  60                
 Ala Ile Thr Ile Asn Thr Ala Ser Pro Lys Phe Ser Ser Ser Ile Phe
  65                  70                  75                  80
 Phe Tyr Gln Leu
                



      <210> 2369
      <211> 225
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(225)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2369
 Pro Val Ser Trp Ser Leu Asn Ser Cys Arg Phe Phe Phe Phe Phe Xaa
   1               5                  10                  15    
 Asp Gln Ser Leu Pro Ser Val Val Gln Ala Gly Ser Gly Gln Xaa Arg
              20                  25                  30        
 Asn Leu Asp Ser Leu Gln Pro Leu Ala Ser Arg Phe Lys Xaa Phe Ser
          35                  40                  45            
 Ser Ser Arg Leu Leu Ser Ser Trp Asp Tyr Arg His Met Ala Thr Met
      50                  55                  60                
 Ala Arg Leu Ile Phe Ile Phe Leu Val Glu Met Gly Phe Thr Met Leu
  65                  70                  75                  80
 Ala Arg Leu Val Leu Asn Phe Leu Thr Ser Ser Asp Pro Pro Thr Ser
                  85                  90                  95    
 Ala Phe Pro Lys Trp Leu Gly Leu Gln Gly Val Lys Pro Asn Thr Arg
             100                 105                 110        
 Ala Val Gly Phe Asn Xaa Xaa Leu Gly Tyr Tyr Ser Ile Ile Leu Tyr
         115                 120                 125            
 His Ser Asn Ser Pro Gly Thr Asp Leu Val Phe Ile Leu Phe Ile Tyr
     130                 135                 140                
 Leu Phe Thr Tyr Leu Phe Leu Arg Gln Glu Gln Asn Ser Ala Ala Gln
 145                 150                 155                 160
 Ala Arg Val Gln Xaa Trp His Asn Leu Gly Ser Leu Gln Ser Pro Pro
                 165                 170                 175    
 Pro Gly Val His Xaa Phe Leu Cys Leu Ser Leu Pro Ser Ser Trp Asp
             180                 185                 190        
 Tyr Arg Cys Ala Pro Pro His Gln Ala Asn Phe Phe Ile Phe Ser Arg
         195                 200                 205            
 Asp Gly Val Ser Pro Cys Trp Pro Gly Trp Ser Xaa Thr Pro Asp Leu
     210                 215                 220                
 Arg
 225



      <210> 2370
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 2370
 Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val
   1               5                  10                  15    
 Ala Ser Lys Ser Met Glu Asn Thr Ala Gln Leu Pro Glu Cys Cys Val
              20                  25                  30        
 Asp Val Val Gly Val Asn Ala Ser Cys Pro Gly Ala Ser Leu Cys Gly
          35                  40                  45            
 Pro Gly Cys Tyr Arg Arg Trp Asn Ala Asp Gly Ser Ala Ser Cys Val
      50                  55                  60                
 Arg Cys Gly Asn Gly Thr Leu Pro Ala Tyr Asn Gly Ser Glu Cys Lys
  65                  70                  75                  80
 Ser Phe Ala Gly Pro Gly Ala Pro Phe Pro Met Asn Arg Ser Ser Gly
                  85                  90                  95    
 Thr Pro Gly Arg Pro His Pro Gly Ala Pro Arg Val Ala Ala Ser Leu
             100                 105                 110        
 Phe Leu Gly Thr Phe Phe Ile Ser Ser Gly Leu Ile Leu Ser Val Ala
         115                 120                 125            
 Gly Phe Phe Tyr Leu Lys Arg Ser Ser Lys Leu Pro Arg Ala Cys Tyr
     130                 135                 140                
 Arg Arg Asn Lys Ala Pro Ala Leu Gln Pro Gly Glu Arg Leu Gln
 145                 150                 155                



      <210> 2371
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 2371
 Val Gly Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly
   1               5                  10                  15    
 His Trp Leu Leu Thr Thr Trp Gly Cys Ile Val Phe Ser Gly Ser Tyr
              20                  25                  30        
 Ala Trp Ala Asn Phe Thr Ile Leu Ala Leu Gly Val Trp Ala Val Ala
          35                  40                  45            
 Gln Arg Asp Ser Ile Asp Ala Ile Ser Met Phe Leu Gly Gly Leu Leu
      50                  55                  60                
 Ala Thr Ile Phe Leu Asp Ile Val His Ile Ser Ile Phe Tyr Pro Arg
  65                  70                  75                  80
 Val Ser Leu Thr Asp Thr Gly Arg Phe Gly Val Gly Met Ala Ile Leu
                  85                  90                  95    
 Ser Leu Leu Leu Lys Pro Leu Ser Cys Cys Phe Val Tyr His Met Tyr
             100                 105                 110        
 Arg Glu Arg Gly Gly Glu Leu Leu Val His Thr Gly Phe Leu Gly Ser
         115                 120                 125            
 Ser Gln Asp Arg Ser Ala Tyr Gln Thr Ile Asp Ser Ala Glu Ala Pro
     130                 135                 140                
 Ala Asp Pro Phe Ala Val Pro Glu Gly Arg Ser Gln Asp Ala Arg Gly
 145                 150                 155                 160
 Tyr
    



      <210> 2372
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 2372
 His Glu Gly Arg Glu Leu Glu Thr Gly Gln Gly Arg Gln Ser Ser Val
   1               5                  10                  15    
 Gly Ala Ala Gln Gly Thr Gly Val Arg Ala Gly Val Arg Ala Gly Thr
              20                  25                  30        
 Thr Gln Ser Gly Arg Arg Arg Ala Arg Val Ser Gly Arg Leu Ala Glu
          35                  40                  45            
 Val Ser Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu
      50                  55                  60                
 Leu Pro Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp
  65                  70                  75                  80
 Cys Asp Ala Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser
                  85                  90                  95    
 Ser Ser Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn
             100                 105                 110        
 Arg Arg Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr
         115                 120                 125            
 Gln Trp Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val
     130                 135                 140                
 Ala Thr Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu
 145                 150                 155                 160
 Leu Met Phe Ser Asp Gly Gly Arg Asn Trp Lys
                 165                 170    



      <210> 2373
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 2373
 His Glu Gly Arg Glu Leu Glu Thr Gly Gln Gly Arg Gln Ser Ser Val
   1               5                  10                  15    
 Gly Ala Ala Gln Gly Thr Gly Val Arg Ala Gly Val Arg Ala Gly Thr
              20                  25                  30        
 Thr Gln Ser Gly Arg Arg Arg Ala Arg Val Ser Gly Arg Leu Ala Glu
          35                  40                  45            
 Val Ser Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu
      50                  55                  60                
 Leu Pro Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp
  65                  70                  75                  80
 Cys Asp Ala Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser
                  85                  90                  95    
 Ser Ser Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn
             100                 105                 110        
 Arg Arg Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr
         115                 120                 125            
 Gln Trp Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val
     130                 135                 140                
 Ala Thr Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu
 145                 150                 155                 160
 Leu Met Phe Ser Asp Gly Gly Arg Asn Trp Lys
                 165                 170    



      <210> 2374
      <211> 358
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(358)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2374
 Gly Arg Val Gly Trp Glu Leu Trp Cys Met Tyr Ile Ser Pro Pro Lys
   1               5                  10                  15    
 Asp Trp Trp Asp Ala Gly Asp Pro Ser Leu Pro Ile Arg Thr Pro Ala
              20                  25                  30        
 Met Ile Gly Cys Ser Phe Val Val Asn Arg Lys Phe Phe Gly Glu Ile
          35                  40                  45            
 Gly Leu Leu Asp Pro Gly Met Asp Val Tyr Gly Gly Glu Asn Ile Glu
      50                  55                  60                
 Leu Gly Ile Lys Val Trp Leu Cys Gly Gly Ser Met Glu Val Leu Pro
  65                  70                  75                  80
 Cys Ser Arg Val Ala His Ile Glu Arg Lys Lys Lys Pro Tyr Asn Ser
                  85                  90                  95    
 Asn Ile Gly Phe Tyr Thr Lys Arg Asn Ala Leu Arg Val Ala Glu Val
             100                 105                 110        
 Trp Met Asp Asp Tyr Lys Ser His Val Tyr Ile Ala Trp Asn Leu Pro
         115                 120                 125            
 Leu Glu Asn Pro Gly Ile Asp Ile Gly Asp Val Ser Glu Arg Arg Ala
     130                 135                 140                
 Leu Arg Lys Ser Leu Lys Cys Lys Asn Phe Gln Trp Tyr Leu Asp His
 145                 150                 155                 160
 Val Tyr Pro Glu Met Arg Arg Tyr Asn Asn Thr Val Ala Tyr Gly Glu
                 165                 170                 175    
 Leu Arg Asn Asn Lys Ala Lys Asp Val Cys Leu Asp Gln Gly Pro Leu
             180                 185                 190        
 Glu Asn His Thr Ala Ile Leu Tyr Pro Cys His Gly Trp Gly Pro Gln
         195                 200                 205            
 Leu Ala Arg Tyr Thr Lys Glu Gly Phe Leu His Leu Gly Ala Leu Gly
     210                 215                 220                
 Thr Thr Thr Leu Leu Pro Asp Thr Arg Cys Leu Val Asp Asn Ser Lys
 225                 230                 235                 240
 Ser Arg Leu Pro Gln Leu Leu Asp Cys Asp Lys Val Lys Ser Ser Leu
                 245                 250                 255    
 Tyr Lys Arg Trp Asn Phe Ile Gln Asn Gly Ala Ile Met Asn Lys Gly
             260                 265                 270        
 Thr Gly Arg Cys Leu Glu Val Glu Asn Arg Gly Leu Ala Gly Ile Asp
         275                 280                 285            
 Leu Ile Leu Arg Ser Cys Thr Gly Gln Arg Trp Thr Ile Lys Asn Ser
     290                 295                 300                
 Ile Lys Xaa Arg Glu Gly Ala Gly Ala Leu Glu Pro Gly Pro Gln Asp
 305                 310                 315                 320
 Met Ala Ala Pro Pro Asn Ile Trp Thr Ser Cys Pro Gly Gly Glu Thr
                 325                 330                 335    
 Ala Arg Gly Arg Gln Val Leu Asp Gly Pro Pro Arg Ala Ser Pro Gly
             340                 345                 350        
 Gln His Arg Asp Pro Gly
         355            



      <210> 2375
      <211> 209
      <212> PRT
      <213> Homo sapiens


      <400> 2375
 Glu Ser Asn Ser Arg Cys Arg Lys Met Pro Gly Glu Arg Cys Arg Gly
   1               5                  10                  15    
 Gly Pro Ala Arg Leu Ser Leu Leu Leu Asp Leu Pro Thr Arg Pro Leu
              20                  25                  30        
 Pro His Pro Arg Gln Val Ile Asp Phe Gly Ser Ala Ser Ile Phe Ser
          35                  40                  45            
 Glu Val Arg Tyr Val Lys Glu Pro Tyr Ile Gln Ser Arg Phe Tyr Arg
      50                  55                  60                
 Ala Pro Glu Ile Leu Leu Gly Leu Pro Phe Cys Glu Lys Val Asp Val
  65                  70                  75                  80
 Trp Ser Leu Gly Cys Val Met Asp Glu Leu His Leu Gly Trp Pro Leu
                  85                  90                  95    
 Tyr Pro Gly Asn Asn Glu Tyr Asp Gln Val Arg Tyr Ile Cys Glu Thr
             100                 105                 110        
 Gln Gly Leu Pro Lys Pro His Leu Leu His Ala Ala Cys Lys Ala His
         115                 120                 125            
 His Phe Phe Lys Arg Asn Pro His Pro Asp Ala Ala Asn Pro Trp Gln
     130                 135                 140                
 Leu Lys Ser Ser Ala Asp Tyr Leu Ala Glu Thr Lys Val Arg Pro Leu
 145                 150                 155                 160
 Glu Arg Arg Lys Tyr Met Leu Lys Ser Leu Asp Gln Ile Glu Thr Val
                 165                 170                 175    
 Asn Gly Gly Ser Val Ala Ser Arg Leu Thr Phe Pro Asp Arg Glu Ala
             180                 185                 190        
 Leu Ala Glu His Ala Asp Leu Lys Ser Met Val Glu Leu Ile Ser Ala
         195                 200                 205            
 Cys
    



      <210> 2376
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 2376
 Pro Arg Thr Gly Met Gly Cys Cys Leu Pro Gly Ala Asp Pro Ala Glu
   1               5                  10                  15    
 Ile Arg Ser Ser Pro Ser Pro Ser Trp Ser Thr Ala Gly Ser Gln Gly
              20                  25                  30        
 Cys Trp Met Thr Ser Phe Ser Pro Cys Ser Cys Ala Pro Cys Cys Ser
          35                  40                  45            
 Ser Gly Cys Ala Cys Thr Thr Gly Phe Val Ser Arg Glu Lys Glu Ser
      50                  55                  60                
 Val
  65



      <210> 2377
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 2377
 Ala Pro Trp Pro Leu Pro Leu Leu Arg Ser Pro Gln Ser Arg Pro His
   1               5                  10                  15    
 Ser Leu Gly Ser Leu Phe Pro Ser Leu Pro Gly Leu Ala Glu Leu Asp
              20                  25                  30        
 Leu Gln Arg Thr Leu Ser Leu Gln Ala Pro Pro Val Lys Glu Gly Pro
          35                  40                  45            
 Leu Phe Ile His Arg Thr Lys Gly Lys Gly Pro Leu Met Ser Ser Ser
      50                  55                  60                
 Phe Lys Lys Leu Tyr Phe Ser Leu Thr Thr Glu Ala Leu Ser Phe Ala
  65                  70                  75                  80
 Lys Thr Pro Ser Ser Lys Cys Val Asn Glu Leu Asn Gln Trp Leu Ser
                  85                  90                  95    
 Ala Leu Arg Lys Val Ser Ile Asn Asn Thr Gly Leu Leu Gly Ser Tyr
             100                 105                 110        
 His Pro Gly Val Phe Arg Gly Asp Lys Trp Ser Cys Cys His Gln Lys
         115                 120                 125            
 Glu Lys Thr Gly Gln Gly Cys Asp Lys Thr Arg Ser Arg Val Thr Leu
     130                 135                 140                
 Gln Glu Trp Asn Asp Pro Leu Asp His Asp Leu Glu Ala Gln Leu Ile
 145                 150                 155                 160
 Tyr Arg His Leu Leu Gly Val Glu Ala Met Leu Trp Glu Arg His Arg
                 165                 170                 175    
 Glu Leu Ser Gly Gly Ala Glu Ala Gly Thr Val Pro Thr Ser Pro Gly
             180                 185                 190        
 Lys Val Pro Glu Asp Ser Leu Ala Arg Leu Leu Arg Val Leu Gln Asp
         195                 200                 205            
 Leu Arg Glu Ala His Ser Ser Ser Pro Ala Gly Ser Pro Pro Ser Glu
     210                 215                 220                
 Pro Asn Cys Leu Leu Glu Leu Gln Thr
 225                 230            



      <210> 2378
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 2378
 Met Arg Cys Gly Trp Gly Pro Leu Gly Cys Leu Gly Thr Gly Ala Pro
   1               5                  10                  15    
 Ala Gly Trp Met Val Leu Gly Ser Pro Arg Ser Gln Leu Gln Arg Ala
              20                  25                  30        
 Arg Trp Ser Arg Ala Ser Leu Ser Ala Phe Gly Trp Glu Ile Arg Leu
          35                  40                  45            
 Arg Pro Glu Gly Pro Lys Ala Pro Arg Gln Leu Leu Leu Val Ala Leu
      50                  55                  60                
 Glu Ser Glu Thr Leu Gly Val His Gly Gly Ala Thr Pro Leu His Cys
  65                  70                  75                  80
 Leu
    



      <210> 2379
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 2379
 Cys Val Asn Thr Phe Gly Ser Tyr Ile Cys Lys Cys His Lys Gly Phe
   1               5                  10                  15    
 Asp Leu Met Tyr Ile Gly Gly Lys Tyr Gln Cys His Asp Ile Asp Glu
              20                  25                  30        
 Cys Ser Leu Gly Gln Tyr Gln Cys Ser Ser Phe Ala Arg Cys Tyr Asn
          35                  40                  45            
 Val Arg Gly Ser Tyr Lys Cys Lys Cys Lys Glu Gly Tyr Gln Gly Asp
      50                  55                  60                
 Gly Leu Thr Cys Val Tyr Ile Pro Lys Val Met Ile Glu Pro Ser Gly
  65                  70                  75                  80
 Pro Ile His Val Pro Lys Gly Asn Gly Thr Ile Leu Lys Gly Asp Thr
                  85                  90                  95    
 Gly Asn Asn Asn Trp Ile Pro Asp Val Gly Ser Thr Trp Trp Pro Pro
             100                 105                 110        
 Lys Thr Pro Tyr Ile Pro Pro Ile Ile Thr Asn Arg Pro Thr Ser Lys
         115                 120                 125            
 Pro Thr Thr Arg Pro Thr Pro Lys Pro Thr Pro Ile Pro Thr Pro Pro
     130                 135                 140                
 Pro Pro Pro Arg Ile Pro Pro
 145                 150    



      <210> 2380
      <211> 477
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(477)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2380
 Leu Arg Arg His Phe Phe Phe Pro Pro Ser Phe Pro Pro Leu Leu Leu
   1               5                  10                  15    
 Pro Ser Leu Pro Leu Ser Ser Pro Leu Ser Ser Phe Pro Pro Arg Ser
              20                  25                  30        
 Ala Gly Ala Cys Trp Gly Glu Arg Leu Val Leu Gln Ala Leu Ala Leu
          35                  40                  45            
 Arg Gly Arg Pro Ala Gly Ser Trp Arg Gly Glu Glu Ala Gly Thr Ala
      50                  55                  60                
 Met Ala Pro Gln Lys His Gly Gly Gly Gly Gly Gly Gly Ser Gly Pro
  65                  70                  75                  80
 Ser Ala Gly Ser Gly Gly Gly Gly Phe Gly Gly Ser Ala Ala Val Ala
                  85                  90                  95    
 Ala Ala Thr Ala Ser Gly Gly Lys Ser Gly Gly Gly Ser Cys Gly Gly
             100                 105                 110        
 Gly Gly Ser Tyr Ser Ala Ser Ser Ser Ser Ser Ala Ala Ala Ala Ala
         115                 120                 125            
 Gly Ala Ala Val Leu Pro Val Lys Lys Pro Lys Met Glu His Val Gln
     130                 135                 140                
 Ala Asp His Glu Leu Phe Leu Gln Ala Phe Glu Lys Pro Thr Gln Ile
 145                 150                 155                 160
 Tyr Arg Phe Leu Xaa Thr Arg Asn Leu Ile Ala Pro Ile Phe Leu His
                 165                 170                 175    
 Arg Thr Leu Thr Tyr Met Ser His Arg Asn Ser Arg Thr Asn Ile Lys
             180                 185                 190        
 Arg Lys Thr Phe Lys Val Asp Asp Met Leu Ser Lys Val Glu Lys Met
         195                 200                 205            
 Lys Gly Glu Gln Glu Ser His Ser Leu Ser Ala His Leu Gln Leu Thr
     210                 215                 220                
 Phe Thr Gly Phe Phe His Lys Asn Asp Lys Pro Ser Pro Asn Ser Glu
 225                 230                 235                 240
 Asn Glu Gln Asn Ser Val Thr Leu Glu Val Leu Leu Val Lys Val Cys
                 245                 250                 255    
 His Lys Lys Arg Lys Asp Val Ser Cys Pro Ile Arg Gln Val Pro Thr
             260                 265                 270        
 Gly Lys Lys Gln Val Pro Leu Asn Pro Asp Leu Asn Gln Thr Lys Pro
         275                 280                 285            
 Gly Asn Phe Pro Ser Leu Ala Val Ser Ser Asn Glu Phe Glu Pro Ser
     290                 295                 300                
 Asn Ser His Met Val Lys Ser Tyr Ser Leu Leu Phe Arg Val Thr Arg
 305                 310                 315                 320
 Pro Gly Arg Arg Glu Phe Asn Gly Met Ile Asn Gly Glu Thr Asn Glu
                 325                 330                 335    
 Asn Ile Asp Val Asn Glu Glu Leu Pro Ala Arg Arg Lys Arg Asn Arg
             340                 345                 350        
 Glu Asp Gly Glu Lys Thr Phe Val Ala Gln Met Thr Val Phe Asp Lys
         355                 360                 365            
 Asn Arg Arg Leu Gln Leu Leu Asp Gly Glu Tyr Glu Val Ala Met Gln
     370                 375                 380                
 Glu Met Glu Glu Cys Pro Ile Ser Lys Lys Arg Ala Thr Trp Glu Thr
 385                 390                 395                 400
 Ile Leu Asp Gly Lys Arg Leu Pro Pro Phe Glu Thr Phe Ser Gln Gly
                 405                 410                 415    
 Pro Thr Leu Gln Phe Thr Leu Arg Trp Thr Gly Glu Thr Asn Asp Lys
             420                 425                 430        
 Ser Thr Ala Pro Ile Ala Lys Pro Leu Ala Thr Arg Asn Ser Glu Ser
         435                 440                 445            
 Leu His Gln Glu Asn Lys Pro Gly Ser Val Lys Pro Thr Gln Thr Ile
     450                 455                 460                
 Ala Val Lys Glu Ser Leu Thr Thr Asp Leu Gln Lys Lys
 465                 470                 475        



      <210> 2381
      <211> 577
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(577)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2381
 Lys Pro Phe Asn Val Gly Leu Ser Leu Asn Lys Thr Glu Arg Leu Gln
   1               5                  10                  15    
 Leu Ser His Gly Gly Cys Lys Ala Arg Thr Ala Val Arg Ala Gly Val
              20                  25                  30        
 Phe Tyr Arg Ala Val Leu Gln Pro Leu Thr Leu Ala Gln Gly Gly Leu
          35                  40                  45            
 Pro Gly Gly Ser Gly Lys Glu Gly Ser Ser Gly Cys Ala Gly Thr Asp
      50                  55                  60                
 Val Gly Glu Gln Ala Ser Gly His Arg Ala Leu Ser Xaa Gln Ala Val
  65                  70                  75                  80
 Thr Pro Ala Pro Ser Xaa Met Gly His Pro Leu Ser Gly Ser Xaa Gly
                  85                  90                  95    
 His Gln Leu Glu Pro Gln Ala Gly Thr Ser Pro Asn Phe Ala Leu Val
             100                 105                 110        
 Thr Leu Gly His Ser Arg Pro Gln Phe Pro Gln Leu Xaa Gly Glu Ala
         115                 120                 125            
 Leu Gly Arg Arg Gly Trp Pro Gln Pro Val Ser Xaa Xaa Pro Gly Val
     130                 135                 140                
 Ser Ile Arg Glu Thr Xaa Glu Ala Ala Arg Arg Gly Ser Ala Ser Ala
 145                 150                 155                 160
 Arg Gln Gly Arg Pro Ser Ser Xaa Gln Gly Thr Cys Xaa Ile Xaa Arg
                 165                 170                 175    
 Thr Ala Gly Val Lys Lys Thr Pro Ala Gly Gln Ala Arg Glu Gly Gln
             180                 185                 190        
 Leu Xaa Gly Gly Thr Ala Ala Cys Gly Ala Val Gly Pro Glu Arg Val
         195                 200                 205            
 Gly Ile Ser Pro Ser Gln Glu His Gly Pro Gly Gly Arg Arg Gly Val
     210                 215                 220                
 Arg Val Asp Lys Asp Thr Pro Ala Glu Ser His Pro His Ser Ile Pro
 225                 230                 235                 240
 Ser Asn Lys Gly Thr Pro Ser Arg Lys Pro Ala Val Phe Pro Gly Ala
                 245                 250                 255    
 Pro Val Pro Pro Ser Leu Thr Pro Leu Ser His Lys Ala Thr Leu Pro
             260                 265                 270        
 Ser Ser Leu Thr Gly Gly Arg Gly Gly Gly Gly Gly Lys Ala Asp Cys
         275                 280                 285            
 Ser Gly Glu Pro Gly Cys Pro Val Leu Cys Gln Gln Met Pro Pro Phe
     290                 295                 300                
 His Leu Pro Leu Ala Pro Ala Ser Asp His Pro Gly Ser Ala Pro Gly
 305                 310                 315                 320
 Leu Gln Pro Pro Gln Arg Lys Pro Glu Gly Leu Pro Gly Arg Cys Arg
                 325                 330                 335    
 Ser Asp Pro Ser Gly Val Pro Thr Ala Pro Glu Ser Gly Pro Gly Pro
             340                 345                 350        
 Gly Glu Pro Arg Pro Gly Thr Gln Asp Ala Leu Val Trp Pro Cys Leu
         355                 360                 365            
 Gly Pro Cys Ser Gly Pro Ser Gln Asp Leu Gly Ser Gly Gly Thr Cys
     370                 375                 380                
 Gly Ser Leu Cys Ser Arg His His Pro Pro Leu Pro Arg Pro Thr Xaa
 385                 390                 395                 400
 Val Ala Ser Ser Xaa Gly Gln Ala Gly Leu Ser Phe Ala His Pro Ser
                 405                 410                 415    
 Pro Pro Ser Arg Ala Glu Leu Gly Gln Asp Ala Asn Ala Thr Pro Pro
             420                 425                 430        
 Ser Ala Xaa Arg Gly Ser Pro Ala Gln Arg Gly Ile Asn Asn Trp Gly
         435                 440                 445            
 Gly Pro Val Gly Gly Ala Gly Trp Ala Arg Pro Gly Gln Glu Ala Thr
     450                 455                 460                
 Pro Ala Gly Thr Glu Tyr Gly Xaa Asp Cys Pro Ser Val Gly Ser Pro
 465                 470                 475                 480
 Gln Ala Gln Asp Gly Gly Gln Gly Arg Arg Cys Glu Gly Gly Gly Pro
                 485                 490                 495    
 Gly Pro Trp Xaa His His Xaa Ala His Ser Pro Cys Gly Ala Ala Gly
             500                 505                 510        
 Cys Trp Pro Arg Cys Arg Arg Ser Ser Ala Ala Asp Gln Arg Ala Ala
         515                 520                 525            
 Gln Gly Ala Pro Pro Cys Ala Gly Thr Gly Ala Ala Arg Arg Ala Arg
     530                 535                 540                
 Val Arg Cys Pro Ala Gly Ala Ala Gly Ser Ala Ala Ala Arg Thr Arg
 545                 550                 555                 560
 Asn Arg Pro Ala Gly Xaa Gln Ser Ala Pro Pro Gly Arg Thr Arg Gly
                 565                 570                 575    
 Ser
    



      <210> 2382
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 2382
 Met Ser Glu Arg Val Glu Arg Asn Trp Ser Thr Gly Gly Trp Leu Leu
   1               5                  10                  15    
 Ala Leu Cys Leu Ala Trp Leu Trp Thr His Leu Thr Leu Ala Ala Leu
              20                  25                  30        
 Gln Pro Pro Thr Ala Thr Val Leu Val Gln Gln Gly Thr Cys Glu Val
          35                  40                  45            
 Ile Ala Ala His Arg Cys Cys Asn Arg Asn Arg Ile Glu Glu Arg Ser
      50                  55                  60                
 Gln Thr Val Lys Cys Ser Cys Phe Ser Gly Gln Val Ala Gly Thr Thr
  65                  70                  75                  80
 Arg Ala Lys Pro Ser Cys Val Asp Asp Leu Leu Leu Ala Ala His Cys
                  85                  90                  95    
 Ala Arg Arg Asp Pro Arg Ala Ala Leu Arg Leu Leu Leu Pro Gln Pro
             100                 105                 110        
 Pro Ser Ser
         115



      <210> 2383
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 2383
 Met Ser Glu Arg Val Glu Arg Asn Trp Ser Thr Gly Gly Trp Leu Leu
   1               5                  10                  15    
 Ala Leu Cys Leu Ala Trp Leu Trp Thr His Leu Thr Leu Ala Ala Leu
              20                  25                  30        
 Gln Pro Pro Thr Ala Thr Val Leu Val Gln Gln Gly Thr Cys Glu Val
          35                  40                  45            
 Ile Ala Ala His Arg Cys Cys Asn Arg Asn Arg Ile Glu Glu Arg Ser
      50                  55                  60                
 Gln Thr Val Lys Cys Ser Cys Phe Ser Gly Gln Val Ala Gly Thr Thr
  65                  70                  75                  80
 Arg Ala Lys Pro Ser Cys Val Asp Asp Leu Leu Leu Ala Ala His Cys
                  85                  90                  95    
 Ala Arg Arg Asp Pro Arg Ala Ala Leu Arg Leu Leu Leu Pro Gln Pro
             100                 105                 110        
 Pro Ser Ser
         115



      <210> 2384
      <211> 375
      <212> PRT
      <213> Homo sapiens


      <400> 2384
 His Gln Gly Pro Ser Thr Pro Pro Ser Trp Ala Met Ser Gly Pro Pro
   1               5                  10                  15    
 Thr Pro Leu Ser Arg Glu Asp Trp His Gln Gly Pro Ser Thr Pro Pro
              20                  25                  30        
 Ser Trp Ala Met Ser Glu Pro Pro Thr Ser Ser Ile Gln Gly Leu Ala
          35                  40                  45            
 Ser Gly Ala Val His Thr Ile Leu Leu Gly Asp Val Arg Ala Thr Tyr
      50                  55                  60                
 Thr Ser Ile Gln Gly Val Thr Ser Gly Val Ser Gln Val Ser Arg Ala
  65                  70                  75                  80
 Ala Gln Met Ala Val Pro Ser Ser Arg Ile Leu Gln Leu Ser Lys Pro
                  85                  90                  95    
 Lys Ala Pro Ala Thr Leu Leu Glu Glu Trp Asp Pro Val Pro Lys Pro
             100                 105                 110        
 Lys Pro His Val Ser Asp His Asn Arg Leu Leu His Leu Ala Lys Val
         115                 120                 125            
 Pro Arg Lys Glu Gly Ser Gly Lys Lys Val Gly Ala Phe Pro Glu Ile
     130                 135                 140                
 Lys Gly Pro Glu Ala Phe Arg Asp Lys Ala Arg Ala Met Glu Ser Gln
 145                 150                 155                 160
 Ser Asn Asp Met Pro Phe Asp Glu Leu Leu Ala Leu Tyr Gly Tyr Glu
                 165                 170                 175    
 Ala Ser Asp Pro Ile Ser Asp Arg Glu Ser Glu Gly Gly Asp Val Asp
             180                 185                 190        
 Pro Asn Leu Pro Asp Met Thr Leu Asp Lys Glu Gln Ile Ala Lys Asp
         195                 200                 205            
 Leu Leu Ser Gly Glu Glu Glu Glu Glu Thr Gln Ser Ser Ala Asp Asp
     210                 215                 220                
 Leu Thr Pro Ser Val Thr Ser His Glu Ala Ser Asp Leu Phe Pro Asn
 225                 230                 235                 240
 Arg Ser Gly Cys Leu Leu Ala Gly Glu Ala Glu Ser Ser Arg Gly Leu
                 245                 250                 255    
 Leu Pro Arg Ala Gln Pro Val Pro Arg Gly Ala Gly Leu Ala Asp Asn
             260                 265                 270        
 Ser Arg Gly Ala Leu Leu Arg Ala His Gly Thr Val Arg Val Gly Thr
         275                 280                 285            
 Thr Ala Thr Val Lys Pro Ala Asp Ala Pro Pro Glu Ser Pro Arg Asp
     290                 295                 300                
 Arg Arg Ser Arg Asn Asp Ser His Arg Pro Thr Gly Pro Ser Glu Ser
 305                 310                 315                 320
 Glu Arg Gln Pro Gln Ser Asn Gln Pro Thr Leu Leu Leu Arg Gly His
                 325                 330                 335    
 Gly Thr Ile Arg Val Arg Thr Thr Ala Thr Val Lys Pro Ala Asp Ala
             340                 345                 350        
 Pro Ala Glu Ser Pro Arg Asp Arg Arg Ser Arg Asn Asp Ser His Gly
         355                 360                 365            
 Gln Ser Ser Arg Arg Ser Cys
     370                 375



      <210> 2385
      <211> 353
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(353)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2385
 Arg His Leu Leu Thr Ile Phe His Lys Leu Lys Ile Tyr Lys Thr Ile
   1               5                  10                  15    
 Asn Lys Ile Asp Phe Lys Lys Lys Arg Val Thr Gln Leu Leu Val Phe
              20                  25                  30        
 Cys Leu Phe Leu Cys Leu Phe Phe Ser Ser Glu Met Val Lys Asn Gln
          35                  40                  45            
 Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe Leu Leu Gly Pro Arg
      50                  55                  60                
 Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu Phe Tyr Val Phe Thr
  65                  70                  75                  80
 Leu Leu Gly Asn Gly Thr Ile Leu Gly Leu Ile Ser Leu Asp Ser Arg
                  85                  90                  95    
 Leu His Thr Pro Met Tyr Phe Phe Leu Ser His Leu Ala Val Val Asn
             100                 105                 110        
 Ile Ala Tyr Ala Cys Asn Thr Val Pro Gln Met Leu Val Asn Leu Leu
         115                 120                 125            
 His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys Met Thr Xaa Thr Phe
     130                 135                 140                
 Leu Phe Leu Ser Phe Ala His Thr Glu Cys Leu Leu Leu Val Leu Met
 145                 150                 155                 160
 Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Phe Ile
                 165                 170                 175    
 Ile Met Thr Trp Lys Val Cys Ile Thr Leu Ala Ile Thr Ser Trp Thr
             180                 185                 190        
 Cys Gly Ser Leu Leu Ala Met Val His Val Ser Leu Ile Leu Arg Leu
         195                 200                 205            
 Pro Phe Cys Gly Pro Arg Glu Ile Asn His Phe Phe Cys Glu Ile Leu
     210                 215                 220                
 Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp Leu Asn Gln Val Val
 225                 230                 235                 240
 Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly Pro Leu Cys Leu Val
                 245                 250                 255    
 Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile Leu Arg Ile Gln Ser
             260                 265                 270        
 Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser His Leu Cys
         275                 280                 285            
 Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val Met Tyr Met Ala Pro
     290                 295                 300                
 Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val Leu Phe Leu Phe Tyr
 305                 310                 315                 320
 Ser Ser Phe Asn Pro Met Leu Asn Pro Leu Ile Tyr Asn Leu Arg Asn
                 325                 330                 335    
 Val Glu Val Lys Gly Ala Leu Arg Arg Ala Leu Cys Lys Glu Ser His
             340                 345                 350        
 Ser
    



      <210> 2386
      <211> 353
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(353)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2386
 Arg His Leu Leu Thr Ile Phe His Lys Leu Lys Ile Tyr Lys Thr Ile
   1               5                  10                  15    
 Asn Lys Ile Asp Phe Lys Lys Lys Arg Val Thr Gln Leu Leu Val Phe
              20                  25                  30        
 Cys Leu Phe Leu Cys Leu Phe Phe Ser Ser Glu Met Val Lys Asn Gln
          35                  40                  45            
 Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe Leu Leu Gly Pro Arg
      50                  55                  60                
 Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu Phe Tyr Val Phe Thr
  65                  70                  75                  80
 Leu Leu Gly Asn Gly Thr Ile Leu Gly Leu Ile Ser Leu Asp Ser Arg
                  85                  90                  95    
 Leu His Thr Pro Met Tyr Phe Phe Leu Ser His Leu Ala Val Val Asn
             100                 105                 110        
 Ile Ala Tyr Ala Cys Asn Thr Val Pro Gln Met Leu Val Asn Leu Leu
         115                 120                 125            
 His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys Met Thr Xaa Thr Phe
     130                 135                 140                
 Leu Phe Leu Ser Phe Ala His Thr Glu Cys Leu Leu Leu Val Leu Met
 145                 150                 155                 160
 Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Phe Ile
                 165                 170                 175    
 Ile Met Thr Trp Lys Val Cys Ile Thr Leu Ala Ile Thr Ser Trp Thr
             180                 185                 190        
 Cys Gly Ser Leu Leu Ala Met Val His Val Ser Leu Ile Leu Arg Leu
         195                 200                 205            
 Pro Phe Cys Gly Pro Arg Glu Ile Asn His Phe Phe Cys Glu Ile Leu
     210                 215                 220                
 Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp Leu Asn Gln Val Val
 225                 230                 235                 240
 Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly Pro Leu Cys Leu Val
                 245                 250                 255    
 Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile Leu Arg Ile Gln Ser
             260                 265                 270        
 Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser His Leu Cys
         275                 280                 285            
 Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val Met Tyr Met Ala Pro
     290                 295                 300                
 Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val Leu Phe Leu Phe Tyr
 305                 310                 315                 320
 Ser Ser Phe Asn Pro Met Leu Asn Pro Leu Ile Tyr Asn Leu Arg Asn
                 325                 330                 335    
 Val Glu Val Lys Gly Ala Leu Arg Arg Ala Leu Cys Lys Glu Ser His
             340                 345                 350        
 Ser
    



      <210> 2387
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 2387
 His Phe Tyr Phe Cys Phe Ser Asp Ile Asn Leu Ala Ala Glu Pro Lys
   1               5                  10                  15    
 Val Asn Arg Gly Lys Ala Gly Val Lys Arg Ser Ala Ala Glu Met Tyr
              20                  25                  30        
 Gly Ser Val Thr Glu His Pro Ser Pro Ser Pro Leu Leu Arg Ser Gly
          35                  40                  45            
 Thr Leu Leu Phe Ile Thr Ala Leu Cys Pro Ser Val Gly Ile Phe Ser
      50                  55                  60                
 Phe
  65



      <210> 2388
      <211> 66
      <212> PRT
      <213> Homo sapiens


      <400> 2388
 Asn Thr Gln Cys Ile Pro Glu Gly Leu Glu Ser Tyr Tyr Ala Glu Gln
   1               5                  10                  15    
 Asp Ser Ser Ala Arg Glu Lys Phe Tyr Thr Val Ile Asn His Tyr Asn
              20                  25                  30        
 Leu Ala Lys Gln Ser Ile Thr Arg Ser Val Ser Pro Trp Met Ser Val
          35                  40                  45            
 Leu Ser Glu Glu Lys Leu Ser Glu Gln Glu Thr Glu Ala Ala Glu Lys
      50                  55                  60                
 Ser Ala
  65    



      <210> 2389
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 2389
 Ser Gly Ser Ser His Ala Ser Asp Gly Ser Gly Phe Gln Glu Leu Arg
   1               5                  10                  15    
 Ile Cys Ser Glu Asp Gln Thr Pro Leu Ile Ala Gly Met Cys Ser Leu
              20                  25                  30        
 Pro Met Ala Arg Tyr Tyr Ile Ile Lys Tyr Ala Asp Gln Lys Ala Leu
          35                  40                  45            
 Tyr Thr Arg Asp Gly Gln Leu Leu Val Gly Asp Pro Val Ala Asp Asn
      50                  55                  60                
 Cys Cys Ala Glu Lys Ile Cys Thr Leu Pro Asn Arg Gly Leu Asp Arg
  65                  70                  75                  80
 Thr Lys Val Pro Ile Phe Leu Gly Ile Gln Gly Gly Ser Arg Cys Leu
                  85                  90                  95    
 Ala Cys Val Glu Thr Glu Glu Gly Pro Ser Leu Gln Leu Glu Asp Val
             100                 105                 110        
 Asn Ile Glu Glu Leu Tyr Lys Gly Gly Glu Glu Ala Thr Arg Phe Thr
         115                 120                 125            
 Phe Phe Gln Ser Ser Ser Gly Ser Ala Phe Arg Leu Glu Ala Ala Ala
     130                 135                 140                
 Trp Pro Gly Trp Phe Leu Cys Gly Pro Ala Glu Pro Gln Gln Pro Val
 145                 150                 155                 160
 Gln Leu Thr Lys Glu Ser Glu Pro Ser Ala Arg Thr Lys Phe Tyr Phe
                 165                 170                 175    
 Glu Gln Ser Trp
             180



      <210> 2390
      <211> 189
      <212> PRT
      <213> Homo sapiens


      <400> 2390
 Ile Leu Asn Glu Arg Leu Ala Asn Tyr Leu Gln Lys Val Arg Met Leu
   1               5                  10                  15    
 Glu Arg Glu Asn Ala Glu Leu Glu Ser Lys Ile Gln Glu Glu Ser Asn
              20                  25                  30        
 Lys Glu Leu Pro Val Leu Cys Pro Asp Tyr Leu Ser Tyr Tyr Thr Thr
          35                  40                  45            
 Ile Glu Glu Leu Gln Gln Lys Ile Leu Cys Thr Lys Ala Glu Asn Ser
      50                  55                  60                
 Arg Leu Val Ser Gln Ile Asp Asn Thr Lys Leu Thr Ala Asp Asp Leu
  65                  70                  75                  80
 Arg Ala Lys Tyr Glu Ala Glu Val Ser Leu Arg Gln Leu Val Glu Ser
                  85                  90                  95    
 Asp Ala Asn Gly Leu Lys Gln Ile Leu Asn Val Leu Thr Leu Gly Lys
             100                 105                 110        
 Ala Asp Leu Glu Ala Gln Val Gln Ser Leu Lys Glu Glu Leu Leu Cys
         115                 120                 125            
 Leu Lys Asn Asn His Lys Glu Glu Ile Asn Ser Leu Gln Cys Gln Leu
     130                 135                 140                
 Gly Glu Arg Leu Asp Ile Glu Val Thr Ala Ala Pro Ser Ala Asp Leu
 145                 150                 155                 160
 Asn Gln Val Leu Gln Glu Met Arg Cys Gln Tyr Glu Pro Ile Met Glu
                 165                 170                 175    
 Thr Asn Arg Lys Asp Val Glu Gln Trp Phe Asn Thr Gln
             180                 185                



      <210> 2391
      <211> 192
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(192)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2391
 Gly Arg Arg Leu Arg Ser Glu Pro Arg Pro Ala Arg Pro Pro Ile Ala
   1               5                  10                  15    
 Arg Ala Trp Pro Pro Ala Pro Gly Ala Asp Gly Arg Ala Arg Arg Thr
              20                  25                  30        
 Arg Val Pro Ala Pro Cys Leu Pro Arg Ala Pro Cys Tyr Gly Val Arg
          35                  40                  45            
 Pro Arg Ala Trp Arg Pro Arg Pro Ala Arg Leu Arg Gly Gly Leu Val
      50                  55                  60                
 Arg Trp Leu Leu Ser Gly Gly Pro Gln Pro Arg Arg Pro Arg Ala Thr
  65                  70                  75                  80
 Glu Arg Pro Ser Ala Gly Thr Gly Ala Ala Pro Arg Arg Thr Glu Pro
                  85                  90                  95    
 Arg Gly Arg Cys Arg Gly Cys Gly Arg Gly Arg Gly Xaa Gly Pro Arg
             100                 105                 110        
 Ala Trp Gly Leu Ala Leu Cys Ser Pro His Ser Cys Ser Gly Ala Ala
         115                 120                 125            
 Trp Gly Pro Thr Thr Gly Ser Gln Arg Ser Trp Pro Ala Val Ala Arg
     130                 135                 140                
 Ser Trp Gln Gly Asp Ser Ser Arg Cys Pro Ala Leu Arg Thr Thr Thr
 145                 150                 155                 160
 Val Thr Ala Gly Ser Lys Ala Ala Leu Pro Glu Ser Ala Ala Glu Val
                 165                 170                 175    
 Ser Pro Met Ser Ser Ser Pro Gly Arg Lys Arg Ser Gly Phe Ala Ala
             180                 185                 190        





      <210> 2392
      <211> 93
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(93)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2392
 Met Gly Ser Leu Cys Phe Leu Pro Ser Leu Gln Tyr Trp Cys Asp Glu
   1               5                  10                  15    
 Leu Lys Val Glu Xaa Lys Thr Gln Gly Arg Gly Phe Pro Leu Pro Gly
              20                  25                  30        
 Ser Pro Ala Ser Ala Ser His Ala Ser Trp Thr Ala Leu Val Lys Gly
          35                  40                  45            
 Val Gly Ser Gly Gln Ala Gln Glu Ala Glu Gly Ser Glu Glu Gln Glu
      50                  55                  60                
 Ile Gly Glu Ser Pro Gly Gln Ser Gln Gly Val Ala Gly Ala Gly Leu
  65                  70                  75                  80
 Gly Leu Asn Glu Gly Gln Val Pro Arg Met Xaa Thr Arg
                  85                  90            



      <210> 2393
      <211> 80
      <212> PRT
      <213> Homo sapiens


      <400> 2393
 Gly Gly Gly Trp Thr Ser Cys Ser Val Arg Phe Leu Glu Gln Gln Asn
   1               5                  10                  15    
 Gln Val Leu Glu Thr Lys Trp Glu Leu Leu Gln Gln Leu Asp Leu Asn
              20                  25                  30        
 Asn Cys Lys Asn Asn Leu Glu Pro Ile Leu Glu Gly Tyr Ile Ser Asn
          35                  40                  45            
 Leu Arg Lys Gln Leu Glu Thr Leu Ser Gly Asp Arg Val Arg Leu Asp
      50                  55                  60                
 Ser Glu Leu Arg Ser Val Arg Asp Val Val Glu Asp Tyr Lys Lys Arg
  65                  70                  75                  80





      <210> 2394
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 2394
 Trp Lys Met Lys Lys Met Cys Asn Trp Leu Arg Ile Ile Asn Tyr Thr
   1               5                  10                  15    
 Pro Asp Met Ala Arg Ala Ala Val Asp Glu Ala Ile Gln Glu Gly Leu
              20                  25                  30        
 Glu Val Trp Ser Lys Val Thr Pro Leu Lys Phe Thr Lys Ile Ser Lys
          35                  40                  45            
 Gly Ile Ala Asp Ile Met Ile Ala Phe Arg Thr Arg Val His Gly Arg
      50                  55                  60                
 Cys Pro Arg Tyr Phe Asp Gly Pro Leu Gly Val Leu Gly His Ala Phe
  65                  70                  75                  80
 Pro Pro Gly Pro Gly Leu Gly Gly Asp Thr His Phe Asp Glu Asp Glu
                  85                  90                  95    
 Asn Trp Thr Lys Asp Gly Ala Asp Leu His Asp Asn Ser Pro Phe Tyr
             100                 105                 110        
 Gly His Asp Gly Cys Leu Ala His Ala Phe Pro Pro Gly Pro Gly Ile
         115                 120                 125            
 Gly Gly Asp Val His Phe Asp Asn Asp Glu Thr Arg Thr Lys Asp Phe
     130                 135                 140                
 Arg
 145



      <210> 2395
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 2395
 Trp Lys Met Lys Lys Met Cys Asn Trp Leu Arg Ile Ile Asn Tyr Thr
   1               5                  10                  15    
 Pro Asp Met Ala Arg Ala Ala Val Asp Glu Ala Ile Gln Glu Gly Leu
              20                  25                  30        
 Glu Val Trp Ser Lys Val Thr Pro Leu Lys Phe Thr Lys Ile Ser Lys
          35                  40                  45            
 Gly Ile Ala Asp Ile Met Ile Ala Phe Arg Thr Arg Val His Gly Arg
      50                  55                  60                
 Cys Pro Arg Tyr Phe Asp Gly Pro Leu Gly Val Leu Gly His Ala Phe
  65                  70                  75                  80
 Pro Pro Gly Pro Gly Leu Gly Gly Asp Thr His Phe Asp Glu Asp Glu
                  85                  90                  95    
 Asn Trp Thr Lys Asp Gly Ala Asp Leu His Asp Asn Ser Pro Phe Tyr
             100                 105                 110        
 Gly His Asp Gly Cys Leu Ala His Ala Phe Pro Pro Gly Pro Gly Ile
         115                 120                 125            
 Gly Gly Asp Val His Phe Asp Asn Asp Glu Thr Arg Thr Lys Asp Phe
     130                 135                 140                
 Arg
 145



      <210> 2396
      <211> 484
      <212> PRT
      <213> Homo sapiens


      <400> 2396
 Met Ala Glu Leu Arg Pro Ser Gly Ala Pro Gly Pro Thr Ala Pro Pro
   1               5                  10                  15    
 Ala Pro Gly Pro Thr Ala Pro Pro Ala Phe Ala Ser Leu Phe Pro Pro
              20                  25                  30        
 Gly Leu His Ala Ile Tyr Gly Glu Cys Arg Arg Leu Tyr Pro Asp Gln
          35                  40                  45            
 Pro Asn Pro Leu Gln Val Thr Ala Ile Val Lys Tyr Trp Leu Gly Gly
      50                  55                  60                
 Pro Asp Pro Leu Asp Tyr Val Ser Met Tyr Arg Asn Val Gly Ser Pro
  65                  70                  75                  80
 Ser Ala Asn Ile Pro Glu His Trp His Tyr Ile Ser Phe Gly Leu Ser
                  85                  90                  95    
 Asp Leu Tyr Gly Asp Asn Arg Val His Glu Phe Thr Gly Thr Asp Gly
             100                 105                 110        
 Pro Ser Gly Phe Gly Phe Glu Leu Thr Phe Arg Leu Lys Arg Glu Thr
         115                 120                 125            
 Gly Glu Ser Ala Pro Pro Thr Trp Pro Ala Glu Leu Met Gln Gly Leu
     130                 135                 140                
 Ala Arg Tyr Val Phe Gln Ser Glu Asn Thr Phe Cys Ser Gly Asp His
 145                 150                 155                 160
 Val Ser Trp His Ser Pro Leu Asp Asn Ser Glu Ser Arg Ile Gln His
                 165                 170                 175    
 Met Leu Leu Thr Glu Asp Pro Gln Met Gln Pro Val Gln Thr Pro Phe
             180                 185                 190        
 Gly Val Val Thr Phe Leu Gln Ile Val Gly Val Cys Thr Glu Glu Leu
         195                 200                 205            
 His Ser Ala Gln Gln Trp Asn Gly Gln Gly Ile Leu Glu Leu Leu Arg
     210                 215                 220                
 Thr Val Pro Ile Ala Gly Gly Pro Trp Leu Ile Thr Asp Met Arg Arg
 225                 230                 235                 240
 Gly Glu Thr Ile Phe Glu Ile Asp Pro His Leu Gln Glu Arg Val Asp
                 245                 250                 255    
 Lys Gly Ile Glu Thr Asp Gly Ser Asn Leu Ser Gly Val Ser Ala Lys
             260                 265                 270        
 Cys Ala Trp Asp Asp Leu Ser Arg Pro Pro Glu Asp Asp Glu Asp Ser
         275                 280                 285            
 Arg Ser Ile Cys Ile Gly Thr Gln Pro Arg Arg Leu Ser Gly Lys Asp
     290                 295                 300                
 Thr Glu Gln Ile Arg Glu Thr Leu Arg Arg Gly Leu Glu Ile Asn Ser
 305                 310                 315                 320
 Lys Pro Val Leu Pro Pro Ile Asn Pro Gln Arg Gln Asn Gly Leu Ala
                 325                 330                 335    
 His Asp Arg Ala Pro Ser Arg Lys Asp Ser Leu Glu Ser Asp Ser Ser
             340                 345                 350        
 Thr Ala Ile Ile Pro His Glu Leu Ile Arg Thr Arg Gln Leu Glu Ser
         355                 360                 365            
 Val His Leu Lys Phe Asn Gln Glu Ser Gly Ala Leu Ile Pro Leu Cys
     370                 375                 380                
 Leu Arg Gly Arg Leu Leu His Gly Arg His Phe Thr Tyr Lys Ser Ile
 385                 390                 395                 400
 Thr Gly Asp Met Ala Ile Thr Phe Val Ser Thr Gly Val Glu Gly Ala
                 405                 410                 415    
 Phe Ala Thr Glu Glu His Pro Tyr Ala Ala His Gly Pro Trp Leu Gln
             420                 425                 430        
 Ile Leu Leu Thr Glu Glu Phe Val Glu Lys Met Leu Glu Asp Leu Glu
         435                 440                 445            
 Asp Leu Thr Ser Pro Glu Glu Phe Lys Leu Pro Lys Glu Tyr Ser Trp
     450                 455                 460                
 Pro Glu Lys Lys Leu Lys Val Ser Ile Leu Pro Asp Val Val Phe Asp
 465                 470                 475                 480
 Ser Pro Leu His
                



      <210> 2397
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 2397
 Met Cys Thr Lys Thr Ile Pro Val Leu Trp Gly Cys Phe Leu Leu Trp
   1               5                  10                  15    
 Asn Leu Tyr Val Ser Ser Ser Gln Thr Ile Tyr Pro Gly Ile Lys Ala
              20                  25                  30        
 Arg Ile Thr Gln Arg Ala Leu Asp Tyr Gly Val Gln Ala Gly Met Lys
          35                  40                  45            
 Met Ile Glu Gln Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly
      50                  55                  60                
 Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe
  65                  70                  75                  80
 Ser Asn Ile Lys Ile Ser Ala Phe Ser Phe Pro Asn Thr Ser Leu Ala
                  85                  90                  95    
 Phe Val Pro Gly Val Gly Ile
             100            



      <210> 2398
      <211> 399
      <212> PRT
      <213> Homo sapiens


      <400> 2398
 Phe Arg Pro Leu Ala Thr Glu Pro Arg Gly Ser Ser Pro Val Gln Leu
   1               5                  10                  15    
 Val Ser Ser Thr Met Ser Val Arg Thr Leu Pro Leu Leu Phe Leu Asn
              20                  25                  30        
 Leu Gly Gly Glu Met Leu Tyr Ile Leu Asp Gln Arg Leu Arg Ala Gln
          35                  40                  45            
 Asn Ile Pro Gly Asp Lys Ala Arg Lys Val Leu Asn Asp Ile Ile Ser
      50                  55                  60                
 Thr Met Phe Asn Arg Lys Phe Met Glu Glu Leu Phe Lys Pro Gln Glu
  65                  70                  75                  80
 Leu Tyr Ser Lys Lys Ala Leu Arg Thr Val Tyr Glu Arg Leu Ala His
                  85                  90                  95    
 Ala Ser Ile Met Lys Leu Asn Gln Ala Ser Met Asp Lys Leu Tyr Asp
             100                 105                 110        
 Leu Met Thr Met Ala Phe Lys Tyr Gln Val Leu Leu Cys Pro Arg Pro
         115                 120                 125            
 Lys Asp Val Leu Leu Val Thr Phe Asn His Leu Asp Thr Ile Lys Gly
     130                 135                 140                
 Phe Ile Arg Asp Ser Pro Thr Ile Leu Gln Gln Val Asp Glu Thr Leu
 145                 150                 155                 160
 Arg Gln Leu Thr Glu Ile Tyr Gly Gly Leu Ser Ala Gly Glu Phe Gln
                 165                 170                 175    
 Leu Ile Arg Gln Thr Leu Leu Ile Phe Phe Gln Asp Leu His Ile Arg
             180                 185                 190        
 Val Ser Met Phe Leu Lys Asp Lys Val Gln Asn Asn Asn Gly Arg Phe
         195                 200                 205            
 Val Leu Pro Val Ser Gly Pro Val Pro Trp Gly Thr Glu Val Pro Gly
     210                 215                 220                
 Leu Ile Arg Met Phe Asn Asn Lys Gly Glu Glu Val Lys Arg Ile Glu
 225                 230                 235                 240
 Phe Lys His Gly Gly Asn Tyr Val Pro Ala Pro Lys Glu Gly Ser Phe
                 245                 250                 255    
 Glu Phe Tyr Gly Asp Arg Val Leu Lys Leu Gly Thr Asn Met Tyr Ser
             260                 265                 270        
 Val Asn Gln Pro Val Glu Thr His Val Ser Gly Ser Ser Lys Asn Leu
         275                 280                 285            
 Ala Ser Trp Thr Gln Glu Ser Ile Ala Pro Asn Pro Leu Ala Lys Glu
     290                 295                 300                
 Glu Leu Asn Phe Leu Ala Arg Leu Met Gly Gly Met Glu Ile Lys Lys
 305                 310                 315                 320
 Pro Ser Gly Pro Glu Pro Gly Phe Arg Leu Asn Leu Phe Thr Thr Asp
                 325                 330                 335    
 Glu Glu Glu Glu Gln Ala Ala Leu Thr Arg Pro Glu Glu Leu Ser Tyr
             340                 345                 350        
 Glu Val Ile Asn Ile Gln Ala Thr Gln Asp Gln Gln Arg Ser Glu Glu
         355                 360                 365            
 Leu Ala Arg Ile Met Gly Glu Phe Glu Ile Thr Glu Gln Pro Arg Leu
     370                 375                 380                
 Ser Thr Ser Lys Gly Asp Asp Leu Leu Ala Met Met Asp Glu Leu
 385                 390                 395                



      <210> 2399
      <211> 399
      <212> PRT
      <213> Homo sapiens


      <400> 2399
 Phe Arg Pro Leu Ala Thr Glu Pro Arg Gly Ser Ser Pro Val Gln Leu
   1               5                  10                  15    
 Val Ser Ser Thr Met Ser Val Arg Thr Leu Pro Leu Leu Phe Leu Asn
              20                  25                  30        
 Leu Gly Gly Glu Met Leu Tyr Ile Leu Asp Gln Arg Leu Arg Ala Gln
          35                  40                  45            
 Asn Ile Pro Gly Asp Lys Ala Arg Lys Val Leu Asn Asp Ile Ile Ser
      50                  55                  60                
 Thr Met Phe Asn Arg Lys Phe Met Glu Glu Leu Phe Lys Pro Gln Glu
  65                  70                  75                  80
 Leu Tyr Ser Lys Lys Ala Leu Arg Thr Val Tyr Glu Arg Leu Ala His
                  85                  90                  95    
 Ala Ser Ile Met Lys Leu Asn Gln Ala Ser Met Asp Lys Leu Tyr Asp
             100                 105                 110        
 Leu Met Thr Met Ala Phe Lys Tyr Gln Val Leu Leu Cys Pro Arg Pro
         115                 120                 125            
 Lys Asp Val Leu Leu Val Thr Phe Asn His Leu Asp Thr Ile Lys Gly
     130                 135                 140                
 Phe Ile Arg Asp Ser Pro Thr Ile Leu Gln Gln Val Asp Glu Thr Leu
 145                 150                 155                 160
 Arg Gln Leu Thr Glu Ile Tyr Gly Gly Leu Ser Ala Gly Glu Phe Gln
                 165                 170                 175    
 Leu Ile Arg Gln Thr Leu Leu Ile Phe Phe Gln Asp Leu His Ile Arg
             180                 185                 190        
 Val Ser Met Phe Leu Lys Asp Lys Val Gln Asn Asn Asn Gly Arg Phe
         195                 200                 205            
 Val Leu Pro Val Ser Gly Pro Val Pro Trp Gly Thr Glu Val Pro Gly
     210                 215                 220                
 Leu Ile Arg Met Phe Asn Asn Lys Gly Glu Glu Val Lys Arg Ile Glu
 225                 230                 235                 240
 Phe Lys His Gly Gly Asn Tyr Val Pro Ala Pro Lys Glu Gly Ser Phe
                 245                 250                 255    
 Glu Phe Tyr Gly Asp Arg Val Leu Lys Leu Gly Thr Asn Met Tyr Ser
             260                 265                 270        
 Val Asn Gln Pro Val Glu Thr His Val Ser Gly Ser Ser Lys Asn Leu
         275                 280                 285            
 Ala Ser Trp Thr Gln Glu Ser Ile Ala Pro Asn Pro Leu Ala Lys Glu
     290                 295                 300                
 Glu Leu Asn Phe Leu Ala Arg Leu Met Gly Gly Met Glu Ile Lys Lys
 305                 310                 315                 320
 Pro Ser Gly Pro Glu Pro Gly Phe Arg Leu Asn Leu Phe Thr Thr Asp
                 325                 330                 335    
 Glu Glu Glu Glu Gln Ala Ala Leu Thr Arg Pro Glu Glu Leu Ser Tyr
             340                 345                 350        
 Glu Val Ile Asn Ile Gln Ala Thr Gln Asp Gln Gln Arg Ser Glu Glu
         355                 360                 365            
 Leu Ala Arg Ile Met Gly Glu Phe Glu Ile Thr Glu Gln Pro Arg Leu
     370                 375                 380                
 Ser Thr Ser Lys Gly Asp Asp Leu Leu Ala Met Met Asp Glu Leu
 385                 390                 395                



      <210> 2400
      <211> 47
      <212> PRT
      <213> Homo sapiens


      <400> 2400
 Asn Lys Ile Asn Met Phe Ile Ala Ala Leu Phe Thr Ile Ala Lys Thr
   1               5                  10                  15    
 Trp Asn Gln Pro Lys Cys Pro Thr Met Ile Asp Trp Ile Lys Lys Arg
              20                  25                  30        
 Gly Ser Ser Arg Val Ala Ser Ser Ser Ser Pro Thr Arg Thr Arg
          35                  40                  45        



      <210> 2401
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 2401
 Met Ile Leu Ile Asn Phe Arg Glu Ile Cys Leu Lys Val Leu His Thr
   1               5                  10                  15    
 Pro Leu Cys Val Ser Gly Gly Cys Val Leu Leu Tyr Ile Leu Ala Leu
              20                  25                  30        
 Thr Cys Cys Tyr Thr Asn Ser Leu Leu Ile Ser His Leu Pro Pro Leu
          35                  40                  45            
 Ser Leu Pro Thr Glu Thr Gln Thr His Leu Phe Met Tyr Arg Val Leu
      50                  55                  60                
 Lys Val Arg Lys Asp Ile Lys Asn His Val Phe His Pro Thr Tyr Leu
  65                  70                  75                  80
 Val Ala Lys Glu Thr Glu Thr Tyr Gly Glu Glu Leu Ile Pro Leu Pro
                  85                  90                  95    
 Pro Cys Arg Glu His Gln Asp
             100            



      <210> 2402
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 2402
 Lys Leu Lys Asp Phe Phe Phe Glu Met Glu Tyr Cys Ser Val Ala Gln
   1               5                  10                  15    
 Ala Gly Val Gln Trp Ser Leu Gln Pro Pro Ser Pro Trp Phe Lys Gln
              20                  25                  30        
 Phe Ser Tyr Val Ser Leu Pro Ser Ser Trp Asp Tyr Ser His Leu Pro
          35                  40                  45            
 Pro Cys Pro Ala Asn Leu Phe Leu Val Glu Met Arg Phe His Leu Val
      50                  55                  60                
 Gly Gln Ala Gly Leu Lys Leu Leu Thr Ser Gly Asp Pro Pro Ala Ser
  65                  70                  75                  80
 Ala Ser Arg Ser Ala Gly Ile Ile Gly Val Ser His His Ala Trp Pro
                  85                  90                  95    
 Lys Ile Lys Arg Phe Tyr Glu Thr Lys Trp Leu Pro Ile Leu Ser Ile
             100                 105                 110        
 Gln Leu Leu Ser Gly Leu Phe Ile Trp Ala Leu Leu Phe Phe Cys Phe
         115                 120                 125            
 Val Leu His Phe Cys Ser Ile Ile Trp Gly Asn Ser Leu Glu Val Phe
     130                 135                 140                
 Pro Glu Ser Val Cys Arg His Asn Lys Ile Cys Val Leu Cys Thr Gln
 145                 150                 155                 160
 Lys His Asn Val Ser Tyr Glu Ser Ile Thr Gln Pro Val
                 165                 170            



      <210> 2403
      <211> 50
      <212> PRT
      <213> Homo sapiens


      <400> 2403
 Met Ser Ser Trp Pro Arg Met Leu Ala His Cys Phe Tyr Leu Leu Lys
   1               5                  10                  15    
 Ala Leu Ser Ser Ser Tyr Leu Ile Lys Glu Met Thr Ile Met Pro Gly
              20                  25                  30        
 Thr Leu Leu Ser Thr Leu Cys Ile Leu Thr His Leu Asn Leu Pro Thr
          35                  40                  45            
 Pro Leu
      50



      <210> 2404
      <211> 38
      <212> PRT
      <213> Homo sapiens


      <400> 2404
 Pro Thr Glu Ser Ala Pro Gly Leu Gly Phe Cys Phe Pro Asp Phe Gly
   1               5                  10                  15    
 Gln Ser Leu Pro Asn Glu Lys Gln Thr Ser Ala Ile Leu Ser Asp His
              20                  25                  30        
 Gln Gln Ser Gln Leu Cys
          35            



      <210> 2405
      <211> 1264
      <212> PRT
      <213> Homo sapiens


      <400> 2405
 Gly Arg Glu Arg Glu Glu Glu Leu Gln Trp Arg Arg Arg Arg Arg Gln
   1               5                  10                  15    
 Arg Arg Gly Ala Ala Ala Pro Ala Ala Pro Ala Gly Gly Ile Glu Ala
              20                  25                  30        
 Val Asn Met Ala Ser Ala Ser Tyr His Ile Ser Asn Leu Leu Glu Lys
          35                  40                  45            
 Met Thr Ser Ser Asp Lys Asp Phe Arg Phe Met Ala Thr Asn Asp Leu
      50                  55                  60                
 Met Thr Glu Leu Gln Lys Asp Ser Ile Lys Leu Asp Asp Asp Ser Glu
  65                  70                  75                  80
 Arg Lys Val Val Lys Met Ile Leu Lys Leu Leu Glu Asp Lys Asn Gly
                  85                  90                  95    
 Glu Val Gln Asn Leu Ala Val Lys Cys Leu Gly Pro Leu Val Ser Lys
             100                 105                 110        
 Val Lys Glu Tyr Gln Val Glu Thr Ile Val Asp Thr Leu Cys Thr Asn
         115                 120                 125            
 Met Leu Ser Asp Lys Glu Gln Leu Arg Asp Ile Ser Ser Ile Gly Leu
     130                 135                 140                
 Lys Thr Val Ile Gly Glu Leu Pro Pro Ala Ser Ser Gly Ser Ala Leu
 145                 150                 155                 160
 Ala Ala Asn Val Cys Lys Lys Ile Thr Gly Arg Leu Thr Ser Ala Ile
                 165                 170                 175    
 Ala Lys Gln Glu Asp Val Ser Val Gln Leu Glu Ala Leu Asp Ile Met
             180                 185                 190        
 Ala Asp Met Leu Ser Arg Gln Gly Gly Leu Leu Val Asn Phe His Pro
         195                 200                 205            
 Ser Ile Leu Thr Cys Leu Leu Pro Gln Leu Thr Ser Pro Arg Leu Ala
     210                 215                 220                
 Val Arg Lys Arg Thr Ile Ile Ala Leu Gly His Leu Val Met Ser Cys
 225                 230                 235                 240
 Gly Asn Ile Val Phe Val Asp Leu Ile Glu His Leu Leu Ser Glu Leu
                 245                 250                 255    
 Ser Lys Asn Asp Ser Met Ser Thr Thr Arg Thr Tyr Ile Gln Cys Ile
             260                 265                 270        
 Ala Ala Ile Ser Arg Gln Ala Gly His Arg Ile Gly Glu Tyr Leu Glu
         275                 280                 285            
 Lys Ile Ile Pro Leu Val Val Lys Phe Cys Asn Val Asp Asp Asp Glu
     290                 295                 300                
 Leu Arg Glu Tyr Cys Ile Gln Ala Phe Glu Ser Phe Val Arg Arg Cys
 305                 310                 315                 320
 Pro Lys Glu Val Tyr Pro His Val Ser Thr Ile Ile Asn Ile Cys Leu
                 325                 330                 335    
 Lys Tyr Leu Thr Tyr Asp Pro Asn Tyr Asn Tyr Asp Asp Glu Asp Glu
             340                 345                 350        
 Asp Glu Asn Ala Met Asp Ala Asp Gly Gly Asp Asp Asp Asp Gln Gly
         355                 360                 365            
 Ser Asp Asp Glu Tyr Ser Asp Asp Asp Asp Met Ser Trp Lys Val Arg
     370                 375                 380                
 Arg Ala Ala Ala Lys Cys Leu Asp Ala Val Val Ser Thr Arg His Glu
 385                 390                 395                 400
 Met Leu Pro Glu Phe Tyr Lys Thr Val Ser Pro Ala Leu Ile Ser Arg
                 405                 410                 415    
 Phe Lys Glu Arg Glu Glu Asn Val Arg Ala Asp Val Phe His Ala Tyr
             420                 425                 430        
 Leu Ser Leu Leu Lys Gln Thr Arg Pro Val Gln Ser Trp Leu Cys Asp
         435                 440                 445            
 Pro Asp Ala Met Glu Gln Gly Glu Thr Pro Leu Thr Met Leu Gln Ser
     450                 455                 460                
 Gln Val Pro Asn Ile Val Lys Ala Leu His Lys Gln Met Lys Glu Lys
 465                 470                 475                 480
 Ser Val Lys Thr Arg Gln Cys Cys Phe Asn Met Leu Thr Glu Leu Val
                 485                 490                 495    
 Asn Val Leu Pro Gly Ala Leu Thr Gln His Ile Pro Val Leu Val Pro
             500                 505                 510        
 Gly Ile Ile Phe Ser Leu Asn Asp Lys Ser Ser Ser Ser Asn Leu Lys
         515                 520                 525            
 Ile Asp Ala Leu Ser Cys Leu Tyr Val Ile Leu Cys Asn His Ser Pro
     530                 535                 540                
 Gln Val Phe His Pro His Val Gln Ala Leu Val Pro Pro Val Val Ala
 545                 550                 555                 560
 Cys Val Gly Asp Pro Phe Tyr Lys Ile Thr Ser Glu Ala Leu Leu Val
                 565                 570                 575    
 Thr Gln Gln Leu Val Lys Val Ile Arg Pro Leu Asp Gln Pro Ser Ser
             580                 585                 590        
 Phe Asp Ala Thr Pro Tyr Ile Lys Asp Leu Phe Thr Cys Thr Ile Lys
         595                 600                 605            
 Arg Leu Lys Ala Ala Asp Ile Asp Gln Glu Val Lys Glu Arg Ala Ile
     610                 615                 620                
 Ser Cys Met Gly Gln Ile Ile Cys Asn Leu Gly Asp Asn Leu Gly Ser
 625                 630                 635                 640
 Asp Leu Pro Asn Thr Leu Gln Ile Phe Leu Glu Arg Leu Lys Asn Glu
                 645                 650                 655    
 Ile Thr Arg Leu Thr Thr Val Lys Ala Leu Thr Leu Ile Ala Gly Ser
             660                 665                 670        
 Pro Leu Lys Ile Asp Leu Arg Pro Val Leu Gly Glu Gly Val Pro Ile
         675                 680                 685            
 Leu Ala Ser Phe Leu Arg Lys Asn Gln Arg Ala Leu Lys Leu Gly Thr
     690                 695                 700                
 Leu Ser Ala Leu Asp Ile Leu Ile Lys Asn Tyr Ser Asp Ser Leu Thr
 705                 710                 715                 720
 Ala Ala Met Ile Asp Ala Val Leu Asp Glu Leu Pro Pro Leu Ile Ser
                 725                 730                 735    
 Glu Ser Asp Met His Val Ser Gln Met Ala Ile Ser Phe Leu Thr Thr
             740                 745                 750        
 Leu Ala Lys Val Tyr Pro Ser Ser Leu Ser Lys Ile Ser Gly Ser Ile
         755                 760                 765            
 Leu Asn Glu Leu Ile Gly Leu Val Arg Ser Pro Leu Leu Gln Gly Gly
     770                 775                 780                
 Ala Leu Ser Ala Met Leu Asp Phe Phe Gln Ala Leu Val Val Thr Gly
 785                 790                 795                 800
 Thr Asn Asn Leu Gly Tyr Met Asp Leu Leu Arg Met Leu Thr Gly Pro
                 805                 810                 815    
 Val Tyr Ser Gln Ser Thr Ala Leu Thr His Lys Gln Ser Tyr Tyr Ser
             820                 825                 830        
 Ile Ala Lys Cys Val Ala Ala Leu Thr Arg Ala Cys Pro Lys Glu Gly
         835                 840                 845            
 Pro Ala Val Val Gly Gln Phe Ile Gln Asp Val Lys Asn Ser Arg Ser
     850                 855                 860                
 Thr Asp Ser Ile Arg Leu Leu Ala Leu Leu Ser Leu Gly Glu Val Gly
 865                 870                 875                 880
 His His Ile Asp Leu Ser Gly Gln Leu Glu Leu Lys Ser Val Ile Leu
                 885                 890                 895    
 Glu Ala Phe Ser Ser Pro Ser Glu Glu Val Lys Ser Ala Ala Ser Tyr
             900                 905                 910        
 Ala Leu Gly Ser Ile Ser Val Gly Asn Leu Pro Glu Tyr Leu Pro Phe
         915                 920                 925            
 Val Leu Gln Glu Ile Thr Ser Gln Pro Lys Arg Gln Tyr Leu Leu Leu
     930                 935                 940                
 His Ser Leu Lys Glu Ile Ile Ser Ser Ala Ser Val Val Gly Leu Lys
 945                 950                 955                 960
 Pro Tyr Val Glu Asn Ile Trp Ala Leu Leu Leu Lys His Cys Glu Cys
                 965                 970                 975    
 Ala Glu Glu Gly Thr Arg Asn Val Val Ala Glu Cys Leu Gly Lys Leu
             980                 985                 990        
 Thr Leu Ile Asp Pro Glu Thr Leu Leu Pro Arg Leu Lys Gly Tyr Leu
         995                1000                1005            
 Ile Ser Gly Ser Ser Tyr Ala Arg Ser Ser Val Val Thr Ala Val Lys
    1010                1015                1020                
 Phe Thr Ile Ser Asp His Pro Gln Pro Ile Asp Pro Leu Leu Lys Asn
1025                1030                1035                1040
 Cys Ile Gly Asp Phe Leu Lys Thr Leu Glu Asp Pro Asp Leu Asn Val
                1045                1050                1055    
 Arg Arg Val Ala Leu Val Thr Phe Asn Ser Ala Ala His Asn Lys Pro
            1060                1065                1070        
 Ser Leu Ile Arg Asp Leu Leu Asp Thr Val Leu Pro His Leu Tyr Asn
        1075                1080                1085            
 Glu Thr Lys Val Arg Lys Glu Leu Ile Arg Glu Val Glu Met Gly Pro
    1090                1095                1100                
 Phe Lys His Thr Val Asp Asp Gly Leu Asp Ile Arg Lys Ala Ala Phe
1105                1110                1115                1120
 Glu Cys Met Tyr Thr Leu Leu Asp Ser Cys Leu Asp Arg Leu Asp Ile
                1125                1130                1135    
 Phe Glu Phe Leu Asn His Val Glu Asp Gly Leu Lys Asp His Tyr Asp
            1140                1145                1150        
 Ile Lys Met Leu Thr Phe Leu Met Leu Val Arg Leu Ser Thr Leu Cys
        1155                1160                1165            
 Pro Ser Ala Val Leu Gln Arg Leu Asp Arg Leu Val Glu Pro Leu Arg
    1170                1175                1180                
 Ala Thr Cys Thr Thr Lys Val Lys Ala Asn Ser Val Lys Gln Glu Phe
1185                1190                1195                1200
 Glu Lys Gln Asp Glu Leu Lys Arg Ser Ala Met Arg Ala Val Ala Ala
                1205                1210                1215    
 Leu Leu Thr Ile Pro Glu Ala Glu Lys Ser Pro Leu Met Ser Glu Phe
            1220                1225                1230        
 Gln Ser Gln Ile Ser Ser Asn Pro Glu Leu Ala Ala Ile Phe Glu Ser
        1235                1240                1245            
 Ile Gln Lys Asp Ser Ser Ser Thr Asn Leu Glu Ser Met Asp Thr Ser
    1250                1255                1260                





      <210> 2406
      <211> 274
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(274)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2406
 Thr His Ala Cys Ala Leu Ile Ser Ser Arg Phe Ile Ile Leu Ser Ser
   1               5                  10                  15    
 Phe His Val Ile Leu Asn Lys Thr Lys His Thr Cys Ile His Thr His
              20                  25                  30        
 Ser Leu Thr Leu Lys Met Gln Asp Glu Glu Arg Tyr Met Thr Leu Asn
          35                  40                  45            
 Val Gln Ser Lys Lys Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe
      50                  55                  60                
 Lys Asp Tyr Ser Val Thr Leu His Trp Tyr Lys Ile Leu Leu Gly Ile
  65                  70                  75                  80
 Ser Gly Thr Val Asn Gly Ile Leu Thr Leu Thr Leu Ile Ser Leu Ile
                  85                  90                  95    
 Leu Leu Val Ser Gln Gly Val Leu Leu Lys Cys Gln Lys Gly Ser Cys
             100                 105                 110        
 Ser Asn Ala Thr Gln Tyr Glu Asp Thr Gly Asp Leu Lys Val Asn Asn
         115                 120                 125            
 Gly Thr Arg Arg Asn Ile Ser Asn Lys Asp Leu Cys Ala Ser Arg Ser
     130                 135                 140                
 Ala Asp Gln Thr Val Leu Cys Gln Ser Glu Trp Leu Lys Tyr Gln Gly
 145                 150                 155                 160
 Lys Cys Tyr Trp Phe Ser Asn Glu Met Lys Ser Trp Ser Asp Ser Tyr
                 165                 170                 175    
 Val Tyr Cys Leu Glu Arg Lys Ser His Leu Leu Ile Ile His Asp Gln
             180                 185                 190        
 Leu Glu Met Ser Leu Val Gln Phe Xaa Ala Phe Ile Gln Lys Asn Leu
         195                 200                 205            
 Arg Gln Leu Asn Tyr Val Trp Ile Gly Leu Asn Phe Thr Ser Leu Lys
     210                 215                 220                
 Met Thr Trp Thr Trp Val Asp Gly Ser Pro Ile Asp Ser Lys Ile Phe
 225                 230                 235                 240
 Phe Ile Lys Gly Pro Ala Lys Glu Asn Ser Cys Ala Ala Ile Lys Glu
                 245                 250                 255    
 Ser Lys Ile Phe Ser Glu Thr Cys Ser Ser Val Phe Lys Trp Ile Cys
             260                 265                 270        
 Gln Tyr
        



      <210> 2407
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 2407
 Met Cys Cys Glu Leu Leu Ala Val Val Ile Ala Thr Leu Ile Ile Lys
   1               5                  10                  15    
 Ile Gly Leu Val Val Leu Leu Tyr Phe Ile Lys Leu Leu Ile His Ile
              20                  25                  30        
 Glu Phe Ile Lys Arg His Ser Ile Leu Lys Cys Glu Ser Ile Phe Asn
          35                  40                  45            
 Leu Asn Val Gly Ile Arg Met Tyr Pro Gly Gln Val Asn Phe Cys Glu
      50                  55                  60                
 Thr Leu Gln Met Leu Asp Gly Phe Gly Arg Ile Phe Gln Thr Lys
  65                  70                  75                



      <210> 2408
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 2408
 Leu Gln Met Ser Ser Leu Pro Thr Ala Ala Pro Ala Leu Asp Val Asp
   1               5                  10                  15    
 Trp Gln Ser Ser Thr Thr Phe Ala Ser Cys Ser Thr Asp Met Cys Ile
              20                  25                  30        
 His Val Cys Arg Leu Gly Cys Asp Arg Pro Val Lys Thr Phe Gln Gly
          35                  40                  45            
 His Thr Val Ser Glu Ser Ser Cys His Trp Ser Arg Val Cys Glu Asn
      50                  55                  60                
 Val Met Trp Glu Pro Ile Leu Val Cys Leu Glu Leu Lys Ala Thr Ala
  65                  70                  75                  80
 Ala Ala Asp Gln Leu
                  85



      <210> 2409
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 2409
 Ala Leu Ser Cys Gly Pro Phe Pro Gln Pro Leu Gly Asp Lys Leu Phe
   1               5                  10                  15    
 Arg Trp Trp Leu Leu Pro Leu Ser Arg Phe Leu Met Arg Val Leu Asp
              20                  25                  30        
 Ser Tyr Gly Asp Asp Tyr Arg Ala Ser Gln Phe Thr Ile Val Leu Glu
          35                  40                  45            
 Val Ser Val Gly Pro Pro Gly Gly Ser Gly Thr Gly Ser Ser Gly Pro
      50                  55                  60                
 Thr His His Leu Pro Pro Pro Pro Ala Cys Gln Asp Glu Gly Ser Gln
  65                  70                  75                  80
 Gly Thr Asp Ala Pro Thr Pro Gly Asn Ala Glu Asn Glu Pro Pro Glu
                  85                  90                  95    
 Lys Glu Thr Leu Ser Pro Pro Arg Arg Thr Pro Ala Pro Pro Glu Pro
             100                 105                 110        
 Gly Ser Pro Ala Pro Gly Glu Gly Pro Ser Gly Arg Lys Arg Arg Arg
         115                 120                 125            
 Val Pro Arg Asp Gly Arg Pro Ala Gly Asn Ala Leu Thr Pro Glu Leu
     130                 135                 140                
 Ala Pro Val Gln Ile Lys Val Glu Glu Asp Phe Gly Phe Glu Ala Asp
 145                 150                 155                 160
 Glu Ala Leu Asp Ser Ser Trp Val Ser Arg Gly Pro Asp Lys Leu Leu
                 165                 170                 175    
 Pro Tyr Pro Thr Leu Ala Ser Pro Ala Phe Asp
             180                 185        



      <210> 2410
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 2410
 Ala Leu Ser Cys Gly Pro Phe Pro Gln Pro Leu Gly Asp Lys Leu Phe
   1               5                  10                  15    
 Arg Trp Trp Leu Leu Pro Leu Ser Arg Phe Leu Met Arg Val Leu Asp
              20                  25                  30        
 Ser Tyr Gly Asp Asp Tyr Arg Ala Ser Gln Phe Thr Ile Val Leu Glu
          35                  40                  45            
 Val Ser Val Gly Pro Pro Gly Gly Ser Gly Thr Gly Ser Ser Gly Pro
      50                  55                  60                
 Thr His His Leu Pro Pro Pro Pro Ala Cys Gln Asp Glu Gly Ser Gln
  65                  70                  75                  80
 Gly Thr Asp Ala Pro Thr Pro Gly Asn Ala Glu Asn Glu Pro Pro Glu
                  85                  90                  95    
 Lys Glu Thr Leu Ser Pro Pro Arg Arg Thr Pro Ala Pro Pro Glu Pro
             100                 105                 110        
 Gly Ser Pro Ala Pro Gly Glu Gly Pro Ser Gly Arg Lys Arg Arg Arg
         115                 120                 125            
 Val Pro Arg Asp Gly Arg Pro Ala Gly Asn Ala Leu Thr Pro Glu Leu
     130                 135                 140                
 Ala Pro Val Gln Ile Lys Val Glu Glu Asp Phe Gly Phe Glu Ala Asp
 145                 150                 155                 160
 Glu Ala Leu Asp Ser Ser Trp Val Ser Arg Gly Pro Asp Lys Leu Leu
                 165                 170                 175    
 Pro Tyr Pro Thr Leu Ala Ser Pro Ala Phe Asp
             180                 185        



      <210> 2411
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 2411
 Ala Leu Ser Cys Gly Pro Phe Pro Gln Pro Leu Gly Asp Lys Leu Phe
   1               5                  10                  15    
 Arg Trp Trp Leu Leu Pro Leu Ser Arg Phe Leu Met Arg Val Leu Asp
              20                  25                  30        
 Ser Tyr Gly Asp Asp Tyr Arg Ala Ser Gln Phe Thr Ile Val Leu Glu
          35                  40                  45            
 Val Ser Val Gly Pro Pro Gly Gly Ser Gly Thr Gly Ser Ser Gly Pro
      50                  55                  60                
 Thr His His Leu Pro Pro Pro Pro Ala Cys Gln Asp Glu Gly Ser Gln
  65                  70                  75                  80
 Gly Thr Asp Ala Pro Thr Pro Gly Asn Ala Glu Asn Glu Pro Pro Glu
                  85                  90                  95    
 Lys Glu Thr Leu Ser Pro Pro Arg Arg Thr Pro Ala Pro Pro Glu Pro
             100                 105                 110        
 Gly Ser Pro Ala Pro Gly Glu Gly Pro Ser Gly Arg Lys Arg Arg Arg
         115                 120                 125            
 Val Pro Arg Asp Gly Arg Pro Ala Gly Asn Ala Leu Thr Pro Glu Leu
     130                 135                 140                
 Ala Pro Val Gln Ile Lys Val Glu Glu Asp Phe Gly Phe Glu Ala Asp
 145                 150                 155                 160
 Glu Ala Leu Asp Ser Ser Trp Val Ser Arg Gly Pro Asp Lys Leu Leu
                 165                 170                 175    
 Pro Tyr Pro Thr Leu Ala Ser Pro Ala Phe Asp
             180                 185        



      <210> 2412
      <211> 380
      <212> PRT
      <213> Homo sapiens


      <400> 2412
 Gly Ile Leu Arg Gln Lys Glu Arg Glu Glu Arg Asn Arg Ile His Lys
   1               5                  10                  15    
 Lys Glu Ile Leu Phe Leu Glu His Leu Leu Val Val Pro Ser Glu Met
              20                  25                  30        
 Ser Ser Leu Ser Gly Lys Val Gln Thr Val Leu Gly Leu Val Glu Pro
          35                  40                  45            
 Ser Lys Leu Gly Arg Thr Leu Thr His Glu His Leu Ala Met Thr Phe
      50                  55                  60                
 Asp Cys Cys Tyr Cys Pro Pro Pro Pro Cys Gln Glu Ala Ile Ser Lys
  65                  70                  75                  80
 Glu Pro Ile Val Met Lys Asn Leu Tyr Trp Ile Gln Lys Asn Ala Tyr
                  85                  90                  95    
 Ser His Lys Glu Asn Leu Gln Leu Asn Gln Glu Thr Glu Ala Ile Lys
             100                 105                 110        
 Glu Glu Leu Leu Tyr Phe Lys Ala Asn Gly Gly Gly Ala Leu Val Glu
         115                 120                 125            
 Asn Thr Thr Thr Gly Ile Ser Arg Asp Thr Gln Thr Leu Lys Arg Leu
     130                 135                 140                
 Ala Glu Glu Thr Gly Val His Ile Ile Ser Gly Ala Gly Phe Tyr Val
 145                 150                 155                 160
 Asp Ala Thr His Ser Ser Glu Thr Arg Ala Met Ser Val Glu Gln Leu
                 165                 170                 175    
 Thr Asp Val Leu Met Asn Glu Ile Leu His Gly Ala Asp Gly Thr Ser
             180                 185                 190        
 Ile Lys Cys Gly Ile Ile Gly Glu Ile Gly Cys Ser Trp Pro Leu Thr
         195                 200                 205            
 Glu Ser Glu Arg Lys Val Leu Gln Ala Thr Ala His Ala Gln Ala Gln
     210                 215                 220                
 Leu Gly Cys Pro Val Ile Ile His Pro Gly Arg Ser Ser Arg Ala Pro
 225                 230                 235                 240
 Phe Gln Ile Ile Arg Ile Leu Gln Glu Ala Gly Ala Asp Ile Ser Lys
                 245                 250                 255    
 Thr Val Met Ser His Leu Asp Arg Thr Ile Leu Asp Lys Lys Glu Leu
             260                 265                 270        
 Leu Glu Phe Ala Gln Leu Gly Cys Tyr Leu Glu Tyr Asp Leu Phe Gly
         275                 280                 285            
 Thr Glu Leu Leu His Tyr Gln Leu Gly Pro Asp Ile Asp Met Pro Asp
     290                 295                 300                
 Asp Asn Lys Arg Ile Arg Arg Val Arg Leu Leu Val Glu Glu Gly Cys
 305                 310                 315                 320
 Glu Asp Arg Ile Leu Val Ala His Asp Ile His Thr Lys Thr Arg Leu
                 325                 330                 335    
 Met Lys Tyr Gly Gly His Gly Tyr Ser His Ile Leu Thr Asn Val Val
             340                 345                 350        
 Pro Lys Met Leu Leu Arg Gly Ile Thr Glu Asn Val Leu Asp Lys Ile
         355                 360                 365            
 Leu Ile Glu Asn Pro Lys Gln Trp Leu Thr Phe Lys
     370                 375                 380



      <210> 2413
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 2413
 Ser Val Tyr Ser Ala Ser Ser Cys Lys Cys Cys Asn Tyr Arg Lys Thr
   1               5                  10                  15    
 Glu Gln Ile Pro Asp Cys Glu Gln Pro Pro Ala Ser Ser Met Pro Glu
              20                  25                  30        
 Arg Pro Ser His Glu Ser Gln Pro Thr Pro Gln Met Met Pro Leu Ser
          35                  40                  45            
 Ala Pro Ser Arg Ala Glu Glu Leu Gly Gln Arg Pro Gly
      50                  55                  60    



      <210> 2414
      <211> 515
      <212> PRT
      <213> Homo sapiens


      <400> 2414
 Val Arg Gly Asp Asp Leu Thr Arg Ala Leu Arg Ala Arg Arg Arg Arg
   1               5                  10                  15    
 Ser Gly Ser Gly Ser Asn Phe Arg Val Val Glu Pro Gln Ala Thr Gly
              20                  25                  30        
 Ile Leu Leu Phe Leu Pro Pro Pro Pro Val Cys Pro Ala Pro Leu Pro
          35                  40                  45            
 Leu Ser Leu Leu Phe Pro Ala Pro Pro Ala Lys Met Asn Ser Ser Asp
      50                  55                  60                
 Glu Glu Lys Gln Leu Gln Leu Ile Thr Ser Leu Lys Glu Gln Ala Ile
  65                  70                  75                  80
 Gly Glu Tyr Glu Asp Leu Arg Ala Glu Asn Gln Lys Thr Lys Glu Lys
                  85                  90                  95    
 Cys Asp Lys Ile Arg Gln Glu Arg Asp Glu Ala Val Lys Lys Leu Glu
             100                 105                 110        
 Glu Phe Gln Lys Ile Ser His Met Val Ile Glu Glu Val Asn Phe Met
         115                 120                 125            
 Gln Asn His Leu Glu Ile Glu Lys Thr Cys Arg Glu Ser Ala Glu Ala
     130                 135                 140                
 Leu Ala Thr Lys Leu Asn Lys Glu Asn Lys Thr Leu Lys Arg Ile Ser
 145                 150                 155                 160
 Met Leu Tyr Met Ala Lys Leu Gly Pro Asp Val Ile Thr Glu Glu Ile
                 165                 170                 175    
 Asn Ile Asp Asp Glu Asp Ser Thr Thr Asp Thr Asp Gly Ala Ala Glu
             180                 185                 190        
 Thr Cys Val Ser Val Gln Cys Gln Lys Gln Ile Lys Glu Leu Arg Asp
         195                 200                 205            
 Gln Ile Val Ser Val Gln Glu Glu Lys Lys Ile Leu Ala Ile Glu Leu
     210                 215                 220                
 Glu Asn Leu Lys Ser Lys Leu Val Glu Val Ile Glu Glu Val Asn Lys
 225                 230                 235                 240
 Val Lys Gln Glu Lys Thr Val Leu Asn Ser Glu Val Leu Glu Gln Arg
                 245                 250                 255    
 Lys Val Leu Glu Lys Cys Asn Arg Val Ser Met Leu Ala Val Glu Glu
             260                 265                 270        
 Tyr Glu Glu Met Gln Val Asn Leu Glu Leu Glu Lys Asp Leu Arg Lys
         275                 280                 285            
 Lys Ala Glu Ser Phe Ala Gln Glu Met Phe Ile Glu Gln Asn Lys Leu
     290                 295                 300                
 Lys Arg Gln Ser His Leu Leu Leu Gln Ser Ser Ile Pro Asp Gln Gln
 305                 310                 315                 320
 Leu Leu Lys Ala Leu Asp Glu Asn Ala Lys Leu Thr Gln Gln Leu Glu
                 325                 330                 335    
 Glu Glu Arg Ile Gln His Gln Gln Lys Val Lys Glu Leu Glu Glu Gln
             340                 345                 350        
 Leu Glu Asn Glu Thr Leu His Lys Glu Ile His Asn Leu Lys Gln Gln
         355                 360                 365            
 Leu Glu Leu Leu Glu Glu Asp Lys Lys Glu Leu Glu Leu Lys Tyr Gln
     370                 375                 380                
 Asn Ser Glu Glu Lys Ala Arg Asn Leu Lys His Ser Val Asp Glu Leu
 385                 390                 395                 400
 Gln Lys Arg Val Asn Gln Ser Glu Asn Ser Val Pro Pro Pro Pro Pro
                 405                 410                 415    
 Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Asn Pro Ile Arg Ser Leu
             420                 425                 430        
 Met Ser Met Ile Arg Lys Arg Ser His Pro Ser Gly Ser Gly Ala Lys
         435                 440                 445            
 Lys Glu Lys Ala Thr Gln Pro Glu Thr Thr Glu Glu Val Thr Asp Leu
     450                 455                 460                
 Lys Arg Gln Ala Val Glu Glu Met Met Asp Arg Ile Lys Lys Gly Val
 465                 470                 475                 480
 His Leu Arg Pro Val Asn Gln Thr Ala Arg Pro Lys Thr Lys Pro Glu
                 485                 490                 495    
 Ser Ser Lys Gly Cys Glu Ser Ala Val Asp Glu Leu Lys Gly Ile Leu
             500                 505                 510        
 Ala Ser Gln
         515



      <210> 2415
      <211> 79
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(79)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2415
 Arg Ser Gly Val Pro Asp Gln Pro Gly Gln His Gly Glu Ala Pro Ser
   1               5                  10                  15    
 Leu Leu Lys Ile Gln Asn Leu Ala Gly Arg Ser Gly Gly Pro Leu Xaa
              20                  25                  30        
 Ser Gln Leu Leu Arg Arg Glu Asn Arg Leu Asn Leu Gly Gly Gly Leu
          35                  40                  45            
 Pro Xaa Ala Lys Ile Ala Pro Arg Leu His Pro Cys Thr Pro Ala Trp
      50                  55                  60                
 Val Thr Asp Arg Asp Ser Val Ser Lys Lys Lys Ile Leu Phe Pro
  65                  70                  75                



      <210> 2416
      <211> 50
      <212> PRT
      <213> Homo sapiens


      <400> 2416
 Met Phe Cys Ser Phe Pro Leu Leu Ile Leu Gln Val Tyr Pro Thr Trp
   1               5                  10                  15    
 Lys Asn Pro Asn Trp His Leu Thr Phe His Thr Ser Val Phe Ser Phe
              20                  25                  30        
 Pro Lys Gly Val Arg Ser Leu Ala Arg Gly Ile Pro Asp His Leu His
          35                  40                  45            
 Ser Ala
      50



      <210> 2417
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 2417
 Met Gln Gln Met Met Trp Ala Gly Leu Leu Cys Pro Gln Leu Glu Trp
   1               5                  10                  15    
 Leu Gln Gly Arg Ala Cys Arg Pro Cys Gly Leu Leu Ala Ser Asp Ala
              20                  25                  30        
 Ala Ala Leu Trp Phe Arg Gly Gly Ile Ser Ala Trp Glu Asp Ser Cys
          35                  40                  45            
 Ala Val Ser Asn Ile Arg His Glu Ala Tyr Asn Cys His Leu Ser Val
      50                  55                  60                
 Phe Leu Asn Arg Cys Ala Asn Glu Leu Thr Val Gln Phe Leu Ile Ile
  65                  70                  75                  80
 Leu Ala Phe Gln Ile Met Leu Ser Cys Ala Val Ile Ala Pro Ala Val
                  85                  90                  95    
 Pro Val Phe Gln Arg Leu Thr Leu Lys Arg Ser Gly Arg Thr Ser Leu
             100                 105                 110        
 Gly Ser Thr Gly Arg Leu His Phe Cys Lys
         115                 120        



      <210> 2418
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 2418
 Met Lys Arg Leu Arg Phe Val Leu Arg Val Phe Gln Met Thr Ala Phe
   1               5                  10                  15    
 Ile Thr Gly Ala His Thr Ile Thr Asn Tyr Ser Asp Arg Arg Leu Tyr
              20                  25                  30        
 Ile Ser Pro Leu Ser His Phe Phe Met Asn Ser Gly Ser Ser Ala Gln
          35                  40                  45            
 Ser Val Leu Ser His Ser Tyr Val Ser Gln Ile Phe Phe Lys Asn Val
      50                  55                  60                
 Ser Lys Tyr Phe
  65            



      <210> 2419
      <211> 556
      <212> PRT
      <213> Homo sapiens


      <400> 2419
 Gln Ser Asp Leu Ser Thr Arg Thr Gln Leu Ala Arg Leu Leu Phe Cys
   1               5                  10                  15    
 Ala Lys Thr Gly Glu Leu Val Gly Thr Met Lys Ile Phe Cys Ser Arg
              20                  25                  30        
 Ala Asn Pro Thr Thr Gly Ser Val Glu Trp Leu Glu Glu Asp Glu His
          35                  40                  45            
 Tyr Asp Tyr His Gln Glu Ile Ala Arg Ser Ser Tyr Ala Asp Met Leu
      50                  55                  60                
 His Asp Lys Asp Arg Asn Val Lys Tyr Tyr Gln Gly Ile Arg Ala Ala
  65                  70                  75                  80
 Val Ser Arg Val Lys Asp Arg Gly Gln Lys Ala Leu Val Leu Asp Ile
                  85                  90                  95    
 Gly Thr Gly Thr Gly Leu Leu Ser Met Met Ala Val Thr Ala Gly Ala
             100                 105                 110        
 Asp Phe Cys Tyr Ala Ile Glu Val Phe Lys Pro Met Ala Asp Ala Ala
         115                 120                 125            
 Val Lys Ile Val Glu Lys Asn Gly Phe Ser Asp Lys Ile Lys Val Ile
     130                 135                 140                
 Asn Lys His Ser Thr Glu Val Thr Val Gly Pro Glu Gly Asp Met Pro
 145                 150                 155                 160
 Cys Arg Ala Asn Ile Leu Val Thr Glu Leu Phe Asp Thr Glu Leu Ile
                 165                 170                 175    
 Gly Glu Gly Ala Leu Pro Ser Tyr Glu His Ala His Arg His Leu Val
             180                 185                 190        
 Glu Glu Asn Cys Glu Ala Val Pro His Arg Ala Thr Val Tyr Ala Gln
         195                 200                 205            
 Leu Val Glu Ser Gly Arg Met Trp Ser Trp Asn Lys Leu Phe Pro Ile
     210                 215                 220                
 His Val Gln Thr Ser Leu Gly Glu Gln Val Ile Val Pro Pro Val Asp
 225                 230                 235                 240
 Val Glu Ser Cys Pro Gly Ala Pro Ser Val Cys Asp Ile Gln Leu Asn
                 245                 250                 255    
 Gln Val Ser Pro Ala Asp Phe Thr Val Leu Ser Asp Val Leu Pro Met
             260                 265                 270        
 Phe Ser Ile Asp Phe Ser Lys Gln Val Ser Ser Ser Ala Ala Cys His
         275                 280                 285            
 Ser Arg Arg Phe Glu Pro Leu Thr Ser Gly Arg Ala Gln Val Val Leu
     290                 295                 300                
 Ser Trp Trp Asp Ile Glu Met Asp Pro Glu Gly Lys Ile Lys Cys Thr
 305                 310                 315                 320
 Met Ala Pro Phe Trp Ala His Ser Asp Pro Glu Glu Met Gln Trp Arg
                 325                 330                 335    
 Asp His Trp Met Gln Cys Val Tyr Phe Leu Pro Gln Glu Glu Pro Val
             340                 345                 350        
 Val Gln Gly Ser Ala Leu Tyr Leu Val Ala His His Asp Asp Tyr Cys
         355                 360                 365            
 Val Trp Tyr Ser Leu Gln Arg Thr Ser Pro Glu Lys Asn Glu Arg Val
     370                 375                 380                
 Arg Gln Met Arg Pro Val Cys Asp Cys Gln Ala His Leu Leu Trp Asn
 385                 390                 395                 400
 Arg Pro Arg Phe Gly Glu Ile Asn Asp Gln Asp Arg Thr Asp Arg Tyr
                 405                 410                 415    
 Val Gln Ala Leu Arg Thr Val Leu Lys Pro Asp Ser Val Cys Leu Cys
             420                 425                 430        
 Val Ser Asp Gly Ser Leu Leu Ser Val Leu Ala His His Leu Gly Val
         435                 440                 445            
 Glu Gln Val Phe Thr Val Glu Ser Ser Ala Ala Ser His Lys Leu Leu
     450                 455                 460                
 Arg Lys Ile Phe Lys Ala Asn His Leu Glu Asp Lys Ile Asn Ile Ile
 465                 470                 475                 480
 Glu Lys Arg Pro Glu Leu Leu Thr Asn Glu Asp Leu Gln Gly Arg Lys
                 485                 490                 495    
 Val Ser Leu Leu Leu Gly Glu Pro Phe Phe Thr Thr Ser Leu Leu Pro
             500                 505                 510        
 Trp His Asn Leu Tyr Phe Trp Tyr Val Arg Thr Ala Val Asp Gln His
         515                 520                 525            
 Leu Gly Pro Gly Ala Met Val Met Pro Tyr Ala Ala Ser Leu His Ala
     530                 535                 540                
 Val Val Val Glu Phe Lys Asp Leu Trp Arg Ile Arg
 545                 550                 555    



      <210> 2420
      <211> 324
      <212> PRT
      <213> Homo sapiens


      <400> 2420
 His Tyr Leu Gly Ser Leu Glu Leu Gly Gln Cys Gly Gln Leu Ser Pro
   1               5                  10                  15    
 Leu Pro Cys Gly Leu Gln Val Ala Leu Tyr Lys Ser Val Pro Thr Arg
              20                  25                  30        
 Leu Leu Ser Arg Ala Trp Gly Arg Leu Asn Gln Val Glu Leu Pro His
          35                  40                  45            
 Trp Leu Arg Arg Pro Val Tyr Ser Leu Tyr Ile Trp Thr Phe Gly Val
      50                  55                  60                
 Asn Met Lys Glu Ala Ala Val Glu Asp Leu His His Tyr Arg Asn Leu
  65                  70                  75                  80
 Ser Glu Phe Phe Arg Arg Lys Leu Lys Pro Gln Ala Arg Pro Val Cys
                  85                  90                  95    
 Gly Leu His Ser Val Ile Ser Pro Ser Asp Gly Arg Ile Leu Asn Phe
             100                 105                 110        
 Gly Gln Val Lys Asn Cys Glu Val Glu Gln Val Lys Gly Val Thr Tyr
         115                 120                 125            
 Ser Leu Glu Ser Phe Leu Gly Pro Arg Met Cys Thr Glu Asp Leu Pro
     130                 135                 140                
 Phe Pro Pro Ala Ala Ser Cys Asp Ser Phe Lys Asn Gln Leu Val Thr
 145                 150                 155                 160
 Arg Glu Gly Asn Glu Leu Tyr His Cys Val Ile Tyr Leu Ala Pro Gly
                 165                 170                 175    
 Asp Tyr His Cys Phe His Ser Pro Thr Asp Trp Thr Val Ser His Arg
             180                 185                 190        
 Arg His Phe Pro Gly Ser Leu Met Ser Val Asn Pro Gly Met Ala Arg
         195                 200                 205            
 Trp Ile Lys Glu Leu Phe Cys His Asn Glu Arg Val Val Leu Thr Gly
     210                 215                 220                
 Asp Trp Lys His Gly Phe Phe Ser Leu Thr Ala Val Gly Ala Thr Asn
 225                 230                 235                 240
 Val Gly Ser Ile Arg Ile Tyr Phe Asp Arg Asp Leu His Thr Asn Ser
                 245                 250                 255    
 Pro Arg His Ser Lys Gly Ser Tyr Asn Asp Phe Ser Phe Val Thr His
             260                 265                 270        
 Thr Asn Arg Glu Gly Val Pro Met Arg Lys Gly Glu His Leu Gly Glu
         275                 280                 285            
 Phe Asn Leu Gly Ser Thr Ile Val Leu Ile Phe Glu Ala Pro Lys Asp
     290                 295                 300                
 Phe Asn Phe Gln Leu Lys Thr Gly Gln Lys Ile Arg Phe Gly Glu Ala
 305                 310                 315                 320
 Leu Gly Ser Leu
                



      <210> 2421
      <211> 222
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(222)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2421
 Gly Cys Pro Gly Cys Cys Ser Pro Arg Cys Cys Leu Ala Gly Ala His
   1               5                  10                  15    
 Ser Asp Gly Pro Gly Pro Gly Ser Ser Cys Ser Ser Arg Gly Arg Gln
              20                  25                  30        
 Val Ser Gly Asn Arg Ala Trp Thr Gly Pro Ser Ser Gln Ala Arg Arg
          35                  40                  45            
 Ser Pro Gly Leu Arg Gly Gln Gly Arg Leu Ala Gly Ala Arg Pro Pro
      50                  55                  60                
 Ser Trp Pro Glu Glu Asp Ser Arg Val Pro Gly Lys Asp Lys Leu Xaa
  65                  70                  75                  80
 Gly Lys Glu Leu Glu Ile Ser Ala Xaa Ser Gln Pro Pro Ser Ala Arg
                  85                  90                  95    
 Pro Pro Ser Gly Cys Thr Ala Pro Gly Ala Asn Arg Asn Ser Trp Thr
             100                 105                 110        
 Asn Ser Ser Glu Arg Ile Leu Arg Ala His Phe Ala Pro Leu Pro Pro
         115                 120                 125            
 Ser Pro Pro Pro Pro Leu Glu Ala Gly Gly Leu Pro Pro Xaa Gly Ala
     130                 135                 140                
 Thr Arg Gly Pro Ser Ala Val Pro Ser Phe Pro Ser Val Ser Gly Asp
 145                 150                 155                 160
 Trp Gly Gly Pro Val Glu Ala Gly Arg Ala Gly Ser Arg Ala Glu Gly
                 165                 170                 175    
 Glu Pro Gly Arg Ala Leu Ala Pro Ser Leu Leu Cys Ser Leu Pro Pro
             180                 185                 190        
 Arg Phe Ala Gly Ser Gln Ala Leu Gly Leu Pro Trp Ala Val Thr Ala
         195                 200                 205            
 Glu Arg Trp Gln Glu Leu Arg Ala Ser Glu Leu Arg Asn Arg
     210                 215                 220        



      <210> 2422
      <211> 169
      <212> PRT
      <213> Homo sapiens


      <400> 2422
 Lys Cys Leu Arg Lys Ser Asp Glu Ala Leu Asn Arg Val Leu Gln Gln
   1               5                  10                  15    
 Ile Arg Val Pro Pro Lys Met Lys Arg Gly Thr Ser Leu His Ser Arg
              20                  25                  30        
 Arg Gly Lys Pro Glu Ala Pro Lys Gly Ser Pro Gln Ile Asn Arg Lys
          35                  40                  45            
 Ser Gly Gln Glu Met Thr Ala Val Met Gln Ser Gly Arg Pro Arg Ser
      50                  55                  60                
 Ser Ser Thr Thr Asp Ala Pro Thr Gly Ser Ala Met Met Glu Ile Ala
  65                  70                  75                  80
 Cys Ala Ala Ala Ala Ala Ala Ala Ala Cys Leu Pro Gly Glu Glu Gly
                  85                  90                  95    
 Thr Ala Glu Arg Ile Glu Arg Leu Glu Val Ser Ser Leu Ala Gln Thr
             100                 105                 110        
 Ser Ser Ala Val Ala Ser Ser Thr Asp Gly Ser Ile His Thr Asp Ser
         115                 120                 125            
 Val Asp Gly Thr Pro Asp Pro Gln Arg Thr Lys Ala Ala Ile Ala His
     130                 135                 140                
 Leu Gln Gln Lys Ile Leu Lys Leu Thr Glu Gln Ile Lys Ile Ala Gln
 145                 150                 155                 160
 Thr Ala Arg Arg Asn Arg Arg Pro Gly
                 165                



      <210> 2423
      <211> 412
      <212> PRT
      <213> Homo sapiens


      <400> 2423
 Asn Ser Ser Gly Val Lys Leu Leu Gln Ala Leu Gly Leu Ser Pro Gly
   1               5                  10                  15    
 Asn Gly Lys Asp His Ser Ile Leu His Ser Arg Asn Asp Leu Glu Glu
              20                  25                  30        
 Ala Phe Ile His Phe Met Gly Lys Gly Ala Ala Ala Glu Arg Phe Phe
          35                  40                  45            
 Ser Asp Lys Glu Thr Phe His Asp Ile Ala Gln Val Ala Ser Glu Phe
      50                  55                  60                
 Pro Gly Ala Gln His Tyr Val Gly Gly Asn Ala Ala Leu Ile Gly Gln
  65                  70                  75                  80
 Lys Phe Ala Ala Asn Ser Asp Leu Lys Val Leu Leu Cys Gly Pro Val
                  85                  90                  95    
 Gly Pro Lys Leu His Glu Leu Leu Asp Asp Asn Val Phe Val Pro Pro
             100                 105                 110        
 Glu Ser Leu Gln Glu Val Asp Glu Phe His Leu Ile Leu Glu Tyr Gln
         115                 120                 125            
 Ala Gly Glu Glu Trp Gly Gln Leu Lys Ala Pro His Ala Asn Arg Phe
     130                 135                 140                
 Ile Phe Ser His Asp Leu Ser Asn Gly Ala Met Asn Met Leu Glu Val
 145                 150                 155                 160
 Phe Val Ser Ser Leu Glu Glu Phe Gln Pro Asp Leu Gly Gly Leu Ser
                 165                 170                 175    
 Gly Leu His Met Met Glu Gly Gln Ser Lys Glu Leu Gln Arg Lys Arg
             180                 185                 190        
 Leu Leu Glu Val Val Thr Ser Ile Ser Asp Ile Pro Thr Gly Ile Pro
         195                 200                 205            
 Val His Leu Glu Leu Gly Ser Met Thr Asn Arg Glu Leu Met Ser Ser
     210                 215                 220                
 Ile Val Leu Gln Gln Val Phe Pro Ala Val Thr Ser Leu Gly Leu Asn
 225                 230                 235                 240
 Glu Gln Glu Leu Leu Phe Leu Thr Gln Ser Ala Ser Gly Pro His Ser
                 245                 250                 255    
 Ser Leu Ser Ser Trp Asn Gly Val Pro Asp Val Gly Met Val Ser Asp
             260                 265                 270        
 Ile Leu Phe Trp Ile Leu Lys Glu His Gly Arg Ser Lys Ser Arg Ala
         275                 280                 285            
 Ser Asp Leu Thr Arg Ile His Phe His Thr Leu Val Tyr His Ile Leu
     290                 295                 300                
 Ala Thr Val Asp Gly His Trp Ala Asn Gln Leu Ala Ala Val Ala Ala
 305                 310                 315                 320
 Gly Ala Arg Val Ala Gly Thr Gln Ala Cys Ala Thr Glu Thr Ile Asp
                 325                 330                 335    
 Thr Ser Arg Val Ser Leu Arg Ala Pro Gln Glu Phe Met Thr Ser His
             340                 345                 350        
 Ser Glu Ala Gly Ser Arg Ile Val Leu Asn Pro Asn Lys Pro Val Val
         355                 360                 365            
 Glu Trp His Arg Glu Gly Ile Ser Phe His Phe Thr Pro Val Leu Val
     370                 375                 380                
 Cys Lys Asp Pro Ile Arg Thr Val Gly Leu Gly Asp Ala Ile Ser Ala
 385                 390                 395                 400
 Glu Gly Leu Phe Tyr Ser Glu Val His Pro His Tyr
                 405                 410        



      <210> 2424
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 2424
 Met Leu Trp Glu Leu Val Leu Leu Gly Glu Pro Leu Val Val Met Ala
   1               5                  10                  15    
 Pro Ser Pro Ser Glu Ser Ser Glu Thr Val Leu Ala Leu Val Asn Cys
              20                  25                  30        
 Ile Ser Pro Leu Lys Tyr Phe Ser Asp Phe Arg Pro Tyr Phe Thr Ile
          35                  40                  45            
 His Asp Ser Glu Phe Lys Glu Tyr Thr Thr Arg Thr Gln Ala Pro Pro
      50                  55                  60                
 Ser Val Ile Leu Gly Val Thr Asn Pro Phe Phe Ala Lys Thr Leu Gln
  65                  70                  75                  80
 His Trp Pro His Ile Ile Arg Ile Gly Asp Leu Lys Pro Thr Gly Glu
                  85                  90                  95    
 Ile Pro Lys Gln Val Lys Val Lys Lys Leu Lys Asn Leu Lys Thr Leu
             100                 105                 110        
 Asp Ser Lys Pro Gly Val Tyr Thr Ser Tyr Lys Pro Tyr Ser Asn
         115                 120                 125        



      <210> 2425
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 2425
 Gly Ser Val Ala Leu His Val Glu Lys Leu Pro Asn Glu Pro Asn Arg
   1               5                  10                  15    
 Leu Leu Ile Leu His Gly Phe Leu Asp Glu Asn Val His Phe Phe His
              20                  25                  30        
 Thr Asn Phe Leu Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln
          35                  40                  45            
 Leu Gln Val Ala Leu Pro Pro Val Ser Pro Gln Ile Tyr Pro Asn Glu
      50                  55                  60                
 Arg His Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr Glu Val Thr
  65                  70                  75                  80
 Leu Leu His Phe Leu Gln Glu Tyr Leu
                  85                



      <210> 2426
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 2426
 Gly Ser Val Ala Leu His Val Glu Lys Leu Pro Asn Glu Pro Asn Arg
   1               5                  10                  15    
 Leu Leu Ile Leu His Gly Phe Leu Asp Glu Asn Val His Phe Phe His
              20                  25                  30        
 Thr Asn Phe Leu Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln
          35                  40                  45            
 Leu Gln Val Ala Leu Pro Pro Val Ser Pro Gln Ile Tyr Pro Asn Glu
      50                  55                  60                
 Arg His Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr Glu Val Thr
  65                  70                  75                  80
 Leu Leu His Phe Leu Gln Glu Tyr Leu
                  85                



      <210> 2427
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 2427
 Gly Ser Val Ala Leu His Val Glu Lys Leu Pro Asn Glu Pro Asn Arg
   1               5                  10                  15    
 Leu Leu Ile Leu His Gly Phe Leu Asp Glu Asn Val His Phe Phe His
              20                  25                  30        
 Thr Asn Phe Leu Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln
          35                  40                  45            
 Leu Gln Val Ala Leu Pro Pro Val Ser Pro Gln Ile Tyr Pro Asn Glu
      50                  55                  60                
 Arg His Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr Glu Val Thr
  65                  70                  75                  80
 Leu Leu His Phe Leu Gln Glu Tyr Leu
                  85                



      <210> 2428
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 2428
 Gly Pro Gly Cys Ile Pro Ala Ala Leu Leu Gln Pro Pro Lys Asp Asp
   1               5                  10                  15    
 Lys Lys Lys Lys Asp Ala Gly Lys Ser Ala Lys Lys Asp Lys Asp Pro
              20                  25                  30        
 Val Asn Lys Ser Gly Gly Lys Ala Lys Lys Lys Val Glu Ile Arg Pro
          35                  40                  45            
 Leu
    



      <210> 2429
      <211> 510
      <212> PRT
      <213> Homo sapiens


      <400> 2429
 Glu Ala Val Gln Val Leu Ile Lys His Ser Ala Asp Val Asn Ala Arg
   1               5                  10                  15    
 Asp Lys Asn Trp Gln Thr Pro Leu His Val Ala Ala Ala Asn Lys Ala
              20                  25                  30        
 Val Lys Cys Ala Glu Val Ile Ile Pro Leu Leu Ser Ser Val Asn Val
          35                  40                  45            
 Ser Asp Arg Gly Gly Arg Thr Ala Leu His His Ala Ala Leu Asn Gly
      50                  55                  60                
 His Val Glu Met Val Asn Leu Leu Leu Ala Lys Gly Ala Asn Ile Asn
  65                  70                  75                  80
 Ala Phe Asp Lys Lys Asp Arg Arg Ala Leu His Trp Ala Ala Tyr Met
                  85                  90                  95    
 Gly His Leu Asp Val Val Ala Leu Leu Ile Asn His Gly Ala Glu Val
             100                 105                 110        
 Thr Cys Lys Asp Lys Lys Gly Tyr Thr Pro Leu His Ala Ala Ala Ser
         115                 120                 125            
 Asn Gly Gln Ile Asn Val Val Lys His Leu Leu Asn Leu Gly Val Glu
     130                 135                 140                
 Ile Asp Glu Ile Asn Val Tyr Gly Asn Thr Ala Leu His Ile Ala Cys
 145                 150                 155                 160
 Tyr Asn Gly Gln Asp Ala Val Val Asn Glu Leu Ile Asp Tyr Gly Ala
                 165                 170                 175    
 Asn Val Asn Gln Pro Asn Asn Asn Gly Phe Thr Pro Leu His Phe Ala
             180                 185                 190        
 Ala Ala Ser Thr His Gly Ala Leu Cys Leu Glu Leu Leu Val Asn Asn
         195                 200                 205            
 Gly Ala Asp Val Asn Ile Gln Ser Lys Asp Gly Lys Ser Pro Leu His
     210                 215                 220                
 Met Thr Ala Val His Gly Arg Phe Thr Arg Ser Gln Thr Leu Ile Gln
 225                 230                 235                 240
 Asn Gly Gly Glu Ile Asp Cys Val Asp Lys Asp Gly Asn Thr Pro Leu
                 245                 250                 255    
 His Val Ala Ala Arg Tyr Gly His Glu Leu Leu Ile Asn Thr Leu Ile
             260                 265                 270        
 Thr Ser Gly Ala Asp Thr Ala Lys Cys Gly Ile His Ser Met Phe Pro
         275                 280                 285            
 Leu His Leu Ala Ala Leu Asn Ala His Ser Asp Cys Cys Arg Lys Leu
     290                 295                 300                
 Leu Ser Ser Gly Gln Lys Tyr Ser Ile Val Ser Leu Phe Ser Asn Glu
 305                 310                 315                 320
 His Val Leu Ser Ala Gly Phe Glu Ile Asp Thr Pro Asp Lys Phe Gly
                 325                 330                 335    
 Arg Thr Cys Leu His Ala Ala Ala Ala Gly Gly Asn Val Glu Cys Ile
             340                 345                 350        
 Lys Leu Leu Gln Ser Ser Gly Ala Asp Phe His Lys Lys Asp Lys Cys
         355                 360                 365            
 Gly Arg Thr Pro Leu His Tyr Ala Ala Ala Asn Cys His Phe His Cys
     370                 375                 380                
 Ile Glu Thr Leu Val Thr Thr Gly Ala Asn Val Asn Glu Thr Asp Asp
 385                 390                 395                 400
 Trp Gly Arg Thr Ala Leu His Tyr Ala Ala Ala Ser Asp Met Asp Arg
                 405                 410                 415    
 Asn Lys Thr Ile Leu Gly Asn Ala His Asp Asn Ser Glu Glu Leu Glu
             420                 425                 430        
 Arg Ala Arg Glu Leu Lys Glu Lys Glu Ala Thr Leu Cys Leu Glu Phe
         435                 440                 445            
 Leu Leu Gln Asn Asp Ala Asn Pro Ser Ile Arg Asp Lys Glu Gly Tyr
     450                 455                 460                
 Asn Ser Ile His Tyr Ala Ala Ala Tyr Gly His Arg Gln Cys Leu Glu
 465                 470                 475                 480
 Leu Leu Leu Glu Arg Thr Asn Ser Gly Phe Glu Glu Ser Asp Ser Gly
                 485                 490                 495    
 Ala Thr Lys Ser Pro Leu His Leu Ala Val Ser Glu Met Pro
             500                 505                 510



      <210> 2430
      <211> 353
      <212> PRT
      <213> Homo sapiens


      <400> 2430
 Pro Trp Ala Val Ser Gln Leu Ala Ser Gly Gly Ala Thr Ile Pro Gly
   1               5                  10                  15    
 Ile Arg Gly Ala Gly Arg Ser Arg Pro Pro Gly Ile Leu Val Pro Ala
              20                  25                  30        
 Cys Thr Ser Glu Gly Pro Ser Ser Gln Tyr Asn Phe Ile Ala Asp Val
          35                  40                  45            
 Val Glu Lys Thr Ala Pro Ala Val Val Tyr Ile Glu Ile Leu Asp Arg
      50                  55                  60                
 His Pro Phe Leu Gly Arg Glu Val Pro Ile Ser Asn Gly Ser Gly Phe
  65                  70                  75                  80
 Val Val Ala Ala Asp Gly Leu Ile Val Thr Asn Ala His Val Val Ala
                  85                  90                  95    
 Asp Arg Arg Arg Val Arg Val Arg Leu Leu Ser Gly Asp Thr Tyr Glu
             100                 105                 110        
 Ala Val Val Thr Ala Val Asp Pro Val Ala Asp Ile Ala Thr Leu Arg
         115                 120                 125            
 Ile Gln Thr Lys Glu Pro Leu Pro Thr Leu Pro Leu Gly Arg Ser Ala
     130                 135                 140                
 Asp Val Arg Gln Gly Glu Phe Val Val Ala Met Gly Ser Pro Phe Ala
 145                 150                 155                 160
 Leu Gln Asn Thr Ile Thr Ser Gly Ile Val Ser Ser Ala Gln Arg Pro
                 165                 170                 175    
 Ala Arg Asp Leu Gly Leu Pro Gln Thr Asn Val Glu Tyr Ile Gln Thr
             180                 185                 190        
 Asp Ala Ala Ile Asp Phe Gly Asn Ser Gly Gly Pro Leu Val Asn Leu
         195                 200                 205            
 Asp Gly Glu Val Ile Gly Val Asn Thr Met Lys Val Thr Ala Gly Ile
     210                 215                 220                
 Ser Phe Ala Ile Pro Ser Asp Arg Leu Arg Glu Phe Leu His Arg Gly
 225                 230                 235                 240
 Glu Lys Lys Asn Ser Ser Ser Gly Ile Ser Gly Ser Gln Arg Arg Tyr
                 245                 250                 255    
 Ile Gly Val Met Met Leu Thr Leu Ser Pro Ser Ile Leu Ala Glu Leu
             260                 265                 270        
 Gln Leu Arg Glu Pro Ser Phe Pro Asp Val Gln His Gly Val Leu Ile
         275                 280                 285            
 His Lys Val Ile Leu Gly Ser Pro Ala His Arg Ala Gly Leu Arg Pro
     290                 295                 300                
 Gly Asp Val Ile Leu Ala Ile Gly Glu Gln Met Val Gln Asn Ala Glu
 305                 310                 315                 320
 Asp Val Tyr Glu Ala Val Arg Thr Gln Ser Gln Leu Ala Val Gln Ile
                 325                 330                 335    
 Arg Arg Gly Arg Glu Thr Leu Thr Leu Tyr Val Thr Pro Glu Val Thr
             340                 345                 350        
 Glu
    



      <210> 2431
      <211> 108
      <212> PRT
      <213> Homo sapiens


      <400> 2431
 Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys Arg
   1               5                  10                  15    
 Arg Ser Pro Gly Ile Thr Cys Cys Val Leu Leu Leu Leu Asn Cys Ser
              20                  25                  30        
 Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Thr Gly Ser Val Ala
          35                  40                  45            
 Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Thr Asp
      50                  55                  60                
 Asn Pro Cys Ile Met Cys Val Cys Leu Asn Lys Glu Val Thr Cys Lys
  65                  70                  75                  80
 Arg Glu Lys Cys Pro Val Leu Ser Arg Asp Cys Ala Leu Ala Ile Lys
                  85                  90                  95    
 Gln Arg Gly Ala Cys Cys Glu Gln Cys Lys Gly Cys
             100                 105            



      <210> 2432
      <211> 184
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(184)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2432
 Gly Ile Ser Gly Lys Ala Gly Gly Ser Met Arg Ser Gly Ser Val Cys
   1               5                  10                  15    
 Ser Gly Ala Ala Ala Met Pro Ile Glu Glu Pro Ala Leu Arg Ser Trp
              20                  25                  30        
 Gln Arg Pro Phe Leu Lys Trp Ala Gly Gly Lys Tyr Ser Leu Leu Pro
          35                  40                  45            
 Glu Leu Asp Arg Leu Ile Pro Ala Gly Lys Arg Leu Ile Glu Pro Phe
      50                  55                  60                
 Val Gly Gly Gly Ser Val Phe Leu Asn Ser Asp Lys His Glu Arg Phe
  65                  70                  75                  80
 Leu Leu Ala Asp Val Ser Ala Asp Leu Ile Asn Leu Tyr Gln Met Leu
                  85                  90                  95    
 Ala Val Val Pro Asp Ser Val Ile Tyr Glu Ala Met Lys Ala Phe Arg
             100                 105                 110        
 His Leu Asn Asp Ala Glu Asn Tyr Thr Leu Ile Arg Glu Ala Phe Asn
         115                 120                 125            
 Ala Gln Arg Leu Asp Ala Val Glu Arg Ala Ala Ala Phe Leu Tyr Leu
     130                 135                 140                
 Asn Arg His Cys Phe Asn Gly Leu Ile Arg Tyr Asn Leu Asp Gly Phe
 145                 150                 155                 160
 Phe Gln Gln Gly His Xaa Glu Arg Xaa Arg Gln Val Phe Pro Arg Gln
                 165                 170                 175    
 Ser Val Val Gln Arg Thr Asp Ser
             180                



      <210> 2433
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 2433
 Gly His Phe Arg Val Pro Ala Leu Gly Tyr Leu Asp Val Arg Ile Val
   1               5                  10                  15    
 Asp Thr Asp Tyr Ser Ser Phe Ala Val Leu Tyr Ile Tyr Lys Glu Leu
              20                  25                  30        
 Glu Gly Ala Leu Ser Thr Met Val Gln Leu Tyr Ser Arg Thr Gln Asp
          35                  40                  45            
 Val Ser Pro Gln Ala Leu Lys Ala Phe Gln Asp Phe Tyr Pro Thr Leu
      50                  55                  60                
 Gly Leu Pro Glu Asp Met Met Val Met Leu Pro Gln Ser Asn Ala Cys
  65                  70                  75                  80
 Asn Pro Glu Ser Lys Glu Ala Pro
                  85            



      <210> 2434
      <211> 438
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(438)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2434
 Leu Arg Lys Glu Gly Arg Cys Arg Arg Gly Ser Asn Arg Gly Val Trp
   1               5                  10                  15    
 Ala Ala Pro Ala Glu Gly Leu Gly Gly Arg Gly Met Leu Gly Val Arg
              20                  25                  30        
 Cys Leu Leu Arg Ser Val Arg Phe Cys Ser Ser Ala Pro Phe Pro Lys
          35                  40                  45            
 His Lys Pro Ser Ala Lys Leu Ser Val Arg Asp Ala Leu Gly Ala Gln
      50                  55                  60                
 Asn Ala Ser Gly Glu Arg Ile Lys Ile Gln Gly Trp Ile Arg Ser Val
  65                  70                  75                  80
 Arg Ser Gln Lys Glu Val Leu Phe Leu His Val Asn Asp Gly Ser Ser
                  85                  90                  95    
 Leu Glu Ser Leu Gln Val Val Ala Asp Ser Gly Leu Asp Ser Arg Glu
             100                 105                 110        
 Leu Thr Phe Gly Ser Ser Val Glu Val Gln Gly Gln Leu Ile Lys Ser
         115                 120                 125            
 Pro Ser Lys Arg Gln Asn Val Glu Leu Lys Ala Glu Lys Ile Lys Val
     130                 135                 140                
 Ile Gly Asn Cys Asp Ala Lys Asp Phe Pro Ile Lys Tyr Lys Glu Arg
 145                 150                 155                 160
 His Pro Leu Glu Tyr Leu Arg Gln Tyr Pro His Phe Arg Cys Arg Thr
                 165                 170                 175    
 Asn Val Leu Gly Ser Ile Leu Arg Ile Arg Ser Glu Ala Thr Ala Ala
             180                 185                 190        
 Ile His Ser Phe Phe Lys Asp Ser Gly Phe Val His Ile His Thr Pro
         195                 200                 205            
 Ile Ile Thr Ser Asn Asp Ser Glu Gly Ala Gly Glu Leu Phe Gln Leu
     210                 215                 220                
 Glu Pro Ser Gly Lys Leu Lys Val Pro Glu Glu Asn Phe Phe Asn Val
 225                 230                 235                 240
 Pro Ala Phe Leu Thr Val Ser Gly Gln Leu His Leu Glu Val Met Ser
                 245                 250                 255    
 Gly Ala Phe Thr Gln Val Phe Thr Phe Gly Pro Thr Phe Arg Ala Glu
             260                 265                 270        
 Asn Ser Gln Ser Arg Arg His Leu Ala Glu Phe Tyr Met Ile Glu Ala
         275                 280                 285            
 Glu Ile Ser Phe Val Asp Ser Leu Gln Asp Leu Met Gln Val Ile Glu
     290                 295                 300                
 Glu Leu Phe Lys Ala Thr Thr Met Met Val Leu Ser Lys Cys Pro Glu
 305                 310                 315                 320
 Asp Val Glu Leu Cys His Lys Phe Ile Ala Pro Gly Gln Lys Asp Arg
                 325                 330                 335    
 Leu Xaa His Met Leu Lys Asn Asn Phe Leu Ile Ile Ser Tyr Thr Glu
             340                 345                 350        
 Ala Val Glu Ile Leu Lys Gln Ala Ser Gln Asn Phe Thr Phe Thr Pro
         355                 360                 365            
 Glu Trp Gly Ala Asp Leu Arg Thr Glu His Glu Lys Tyr Leu Val Lys
     370                 375                 380                
 His Cys Gly Asn Ile Pro Val Phe Val Ile Asn Tyr Pro Leu Thr Leu
 385                 390                 395                 400
 Lys Pro Phe Tyr Met Arg Asp Asn Glu Asp Gly Pro Gln Glu Leu Glu
                 405                 410                 415    
 Gly Ser Val Ala Xaa His Ser Leu Gly Leu Met Ile Leu Leu Ser Ile
             420                 425                 430        
 Val Val Ile Gly Gln Pro
         435            



      <210> 2435
      <211> 148
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(148)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2435
 Gly Asn Lys Ala Phe Val Cys Phe Tyr Leu Ser Gln Leu Glu Asn Tyr
   1               5                  10                  15    
 Gly Met Pro Phe Ser Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala
              20                  25                  30        
 Phe Gly Gly Gln Ser Leu Lys Phe Gly Lys Gly Arg Gln Ala His Arg
          35                  40                  45            
 Cys Cys Cys Val Ala Asp Arg Thr Gly His Ser Ile Leu His Thr Ser
      50                  55                  60                
 Tyr Gly Arg Ser Leu Arg Tyr Asp Thr Ser Tyr Phe Val Glu Tyr Phe
  65                  70                  75                  80
 Ala Leu Asp Leu Leu Met Glu Asn Arg Glu Cys Arg Gly Val Ile Ala
                  85                  90                  95    
 Gln Cys Asn Glu Asp Gly Ser Ile His His Ile Arg Ala Lys Asn Thr
             100                 105                 110        
 Val Val Ala Thr Gly Xaa Glu Ser Asn Phe Tyr Phe Ile Ser Phe Val
         115                 120                 125            
 Lys Met Asn Lys Phe Leu Leu Glu Cys Leu Tyr Phe Lys Glu Asn Arg
     130                 135                 140                
 Gly Ile Val Glu
 145            



      <210> 2436
      <211> 237
      <212> PRT
      <213> Homo sapiens


      <400> 2436
 Asp Ser Leu Asp Asn His Arg Cys Arg Gly Asp Leu Thr Lys Thr Tyr
   1               5                  10                  15    
 Ser Leu Glu Ala Tyr Asp Asn Trp Phe Asn Cys Leu Ser Met Leu Val
              20                  25                  30        
 Ala Thr Glu Val Cys Arg Val Val Lys Lys Lys His Arg Thr Arg Met
          35                  40                  45            
 Leu Glu Phe Phe Ile Asp Val Ala Arg Glu Cys Phe Asn Ile Gly Asn
      50                  55                  60                
 Phe Asn Ser Met Met Ala Ile Ile Ser Gly Met Asn Leu Ser Pro Val
  65                  70                  75                  80
 Ala Arg Leu Lys Lys Thr Trp Ser Lys Val Lys Thr Ala Lys Phe Asp
                  85                  90                  95    
 Val Leu Glu His His Met Asp Pro Ser Ser Asn Phe Cys Asn Tyr Arg
             100                 105                 110        
 Thr Ala Leu Gln Gly Ala Thr Gln Arg Ser Gln Met Ala Asn Ser Ser
         115                 120                 125            
 Arg Glu Lys Ile Val Ile Pro Val Phe Asn Leu Phe Val Lys Asp Ile
     130                 135                 140                
 Tyr Phe Leu Pro Gln Asn Pro Ser Asn His Leu Pro Asn Gly His Ile
 145                 150                 155                 160
 Asn Phe Lys Lys Phe Trp Glu Ile Ser Arg Gln Ile His Glu Phe Met
                 165                 170                 175    
 Thr Trp Thr Gln Val Glu Cys Pro Phe Glu Lys Asp Lys Lys Ile Pro
             180                 185                 190        
 Ser Tyr Leu Leu Thr Ala Pro His Pro Thr Ala Arg Lys Leu Ser Ser
         195                 200                 205            
 Ser Pro Ser Phe Glu Ser Glu Gly Pro Glu Asn His Met Glu Lys Asp
     210                 215                 220                
 Ser Trp Lys Thr Leu Arg Thr Thr Leu Leu Asn Arg Ala
 225                 230                 235        



      <210> 2437
      <211> 199
      <212> PRT
      <213> Homo sapiens


      <400> 2437
 Ile Thr Cys Cys Gly Tyr Asp Ala Leu Ser Ser Ile Arg Lys Asn Leu
   1               5                  10                  15    
 Cys Cys Leu Trp Ile Cys Ser Lys Pro Tyr Ser Leu Leu Met Gly Glu
              20                  25                  30        
 Gly Asp Ala Phe Trp Ala Pro Ser Val Leu Pro His Ser Thr Leu Ser
          35                  40                  45            
 Thr Leu Ser His His Pro Gln Pro Gln Phe Gly Arg Gly Met Glu Ser
      50                  55                  60                
 Lys Val Ser Gln Gly Gly Leu Asn Val Thr Leu Thr Ile Arg Leu Leu
  65                  70                  75                  80
 Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys Gly Glu Thr
                  85                  90                  95    
 Val Lys Lys Met Arg Glu Glu Ser Gly Ala Arg Ile Asn Ile Ser Glu
             100                 105                 110        
 Gly Asn Cys Pro Glu Arg Ile Val Thr Ile Thr Gly Pro Thr Asp Ala
         115                 120                 125            
 Ile Phe Lys Ala Phe Ala Met Ile Ala Tyr Lys Phe Glu Glu Asp Ile
     130                 135                 140                
 Ile Asn Ser Met Ser Asn Ser Pro Ala Thr Ser Lys Pro Pro Val Thr
 145                 150                 155                 160
 Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu Ile Gly Lys
                 165                 170                 175    
 Gly Gly Ser Lys Ile Lys Glu Ile Arg Glu Val Thr Gly Pro Ser Gln
             180                 185                 190        
 Pro Gly Pro Leu Arg Ser Leu
         195                



      <210> 2438
      <211> 51
      <212> PRT
      <213> Homo sapiens


      <400> 2438
 Asp Thr Leu Ile Tyr Thr Cys Ala Pro Glu Phe Asp Phe Met Glu Lys
   1               5                  10                  15    
 Ala Thr Pro Leu Arg Tyr Thr Lys Thr Leu Leu Leu Pro Val Val Met
              20                  25                  30        
 Val Ile Thr Cys Phe Ile Phe Lys Lys Thr Val Arg Asp Ile Ser Cys
          35                  40                  45            
 Val Leu Ala
      50    



      <210> 2439
      <211> 408
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(408)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2439
 Thr Gly Gly Arg Val Gly Gly Ser Arg Ser Arg Arg Ala Leu Pro Leu
   1               5                  10                  15    
 Pro Ala Pro Val Glu Ala Gly Val Leu Thr Ser Ala Gly Pro Ser Gly
              20                  25                  30        
 Val Val Trp Gln Arg Ile Glu Asp Thr Thr Lys Met Ala Ala Val Ser
          35                  40                  45            
 Gly Leu Val Arg Arg Pro Leu Arg Glu Val Ser Gly Leu Leu Lys Arg
      50                  55                  60                
 Arg Phe His Trp Thr Ala Pro Ala Ala Val Gln Val Thr Val Arg Asp
  65                  70                  75                  80
 Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu Arg Asp Glu Lys Val
                  85                  90                  95    
 Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp Gly Ala Tyr Lys Val
             100                 105                 110        
 Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys Arg Ile Ile Asp Thr
         115                 120                 125            
 Pro Ile Ser Glu Met Gly Phe Ala Trp Glu Leu Leu Val Gly Ala Ala
     130                 135                 140                
 Ile Gly Trp Gly Leu Arg Pro Ile Leu Leu Asn Leu Trp Thr Phe Asn
 145                 150                 155                 160
 Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala Lys Thr
                 165                 170                 175    
 Tyr Tyr Met Ser Gly Gly Leu Gln Pro Val Leu Ile Val Ser Trp Gly
             180                 185                 190        
 Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln Cys Phe
         195                 200                 205            
 Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser Pro Trp
     210                 215                 220                
 Thr Ser Xaa Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg Asp Asn
 225                 230                 235                 240
 Asn Pro Val Val Ala Leu Glu Asn Glu Leu Met Tyr Gly Val Pro Phe
                 245                 250                 255    
 Glu Phe Pro Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro Ile Gly
             260                 265                 270        
 Lys Ala Lys Ile Glu Met His Gly Thr His Ile Thr Val Val Ser His
         275                 280                 285            
 Ser Arg Pro Val Gly His Cys Leu Arg Ser Leu Pro Ala Ser Val Leu
     290                 295                 300                
 Ser Lys Glu Gly Val Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg
 305                 310                 315                 320
 Pro Met Asp Met Glu Thr Ile Glu Ala Ser Val Met Lys Thr Lys Phe
                 325                 330                 335    
 Ile Leu Xaa Leu Trp Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala
             340                 345                 350        
 Glu Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp
         355                 360                 365            
 Ala Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala
     370                 375                 380                
 Lys Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe
 385                 390                 395                 400
 Ala Ile Lys Lys Thr Leu Asn Ile
                 405            



      <210> 2440
      <211> 427
      <212> PRT
      <213> Homo sapiens


      <400> 2440
 Ala Pro Asn Ser Glu Ser Gly Thr Gln Gly Pro Leu Pro Thr Pro Ala
   1               5                  10                  15    
 Asn Leu Phe Trp Thr Arg Arg Ala Asn Pro Asp Pro Thr Thr Ser Met
              20                  25                  30        
 Ser Ala Thr Asp Arg Met Gly Pro Lys Ala Val Pro Gly Leu Arg Leu
          35                  40                  45            
 Ala Leu Leu Leu Leu Leu Gly Leu Gly Thr Pro Lys Ser Gly Val Gln
      50                  55                  60                
 Gly Gln Glu Gly Leu Asp Phe Pro Glu Tyr Asp Gly Val Asp Arg Val
  65                  70                  75                  80
 Ile Asn Val Asn Ala Lys Asn Tyr Lys Asn Val Phe Lys Lys Tyr Glu
                  85                  90                  95    
 Val Leu Ala Leu Leu Tyr His Glu Pro Pro Glu Asp Asp Lys Ala Ser
             100                 105                 110        
 Gln Arg Gln Phe Glu Met Glu Glu Leu Ile Leu Glu Leu Ala Ala Gln
         115                 120                 125            
 Val Leu Glu Asp Lys Gly Val Gly Phe Gly Leu Val Asp Ser Glu Lys
     130                 135                 140                
 Asp Ala Ala Val Ala Lys Lys Leu Gly Leu Thr Glu Val Asp Ser Met
 145                 150                 155                 160
 Tyr Val Phe Lys Gly Asp Glu Val Ile Glu Tyr Asp Gly Glu Phe Ser
                 165                 170                 175    
 Ala Asp Thr Ile Val Glu Phe Leu Leu Asp Val Leu Glu Asp Pro Val
             180                 185                 190        
 Glu Leu Ile Glu Gly Glu Arg Glu Leu Gln Ala Phe Glu Asn Ile Glu
         195                 200                 205            
 Asp Glu Ile Lys Leu Ile Gly Tyr Phe Lys Ser Lys Asp Ser Glu His
     210                 215                 220                
 Tyr Lys Ala Phe Glu Asp Ala Ala Glu Glu Phe His Pro Tyr Ile Pro
 225                 230                 235                 240
 Phe Phe Ala Thr Phe Asp Ser Lys Gly Ala Lys Lys Leu Thr Leu Lys
                 245                 250                 255    
 Leu Asn Glu Ile Asp Phe Tyr Glu Ala Phe Met Glu Glu Pro Val Thr
             260                 265                 270        
 Ile Pro Asp Lys Pro Asn Ser Glu Glu Glu Ile Val Asn Phe Val Glu
         275                 280                 285            
 Glu His Arg Arg Ser Thr Leu Arg Lys Leu Lys Pro Glu Ser Met Tyr
     290                 295                 300                
 Glu Thr Trp Glu Asp Asp Met Asp Gly Ile His Ile Val Ala Phe Ala
 305                 310                 315                 320
 Glu Glu Ala Asp Pro Asp Gly Phe Glu Phe Leu Glu Thr Leu Lys Ala
                 325                 330                 335    
 Val Ala Gln Asp Asn Thr Glu Asn Pro Asp Leu Ser Ile Ile Trp Ile
             340                 345                 350        
 Asp Pro Asp Asp Phe Pro Leu Leu Val Pro Tyr Trp Glu Lys Thr Phe
         355                 360                 365            
 Asp Ile Asp Leu Ser Ala Pro Gln Ile Gly Val Val Asn Val Thr Asp
     370                 375                 380                
 Ala Asp Arg Leu Trp Met Glu Met Asp Asp Glu Glu Asp Leu Pro Ser
 385                 390                 395                 400
 Ala Glu Glu Leu Glu Asp Trp Leu Glu Asp Val Leu Glu Gly Glu Ile
                 405                 410                 415    
 Asn Thr Glu Asp Asp Asp Asp Asp Asp Asp Asp
             420                 425        



      <210> 2441
      <211> 402
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(402)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2441
 Val Tyr Pro Tyr Asn Pro Leu Ala Phe Phe Arg Glu Arg Leu Gln Pro
   1               5                  10                  15    
 Asn Cys Pro Phe His Ser Ser Glu Gly Ser Ser Gly Lys Leu Ser Xaa
              20                  25                  30        
 Pro Pro Ser Pro Ser Phe Thr Ser Ser Leu Cys Asp Ser Arg Thr Ser
          35                  40                  45            
 Gly Phe Gly Ala Ser Ser Thr Thr His Xaa His Ser Xaa Ile Arg Ala
      50                  55                  60                
 Thr Leu Ile Ser Ser Ala Phe Thr Leu Ala Val Ala Trp Ala Ala Leu
  65                  70                  75                  80
 Leu Cys Pro Pro Ile Ser Ser Cys Ser Ser Glu Thr Trp Leu Ser Leu
                  85                  90                  95    
 Arg Gln Met Gly Ser Glu Pro Lys Val Gln Pro Ser Cys Cys Glu Ala
             100                 105                 110        
 Ser Pro Ser Ser Val His Leu Pro Pro Leu Pro Ser Trp Ala Val Ser
         115                 120                 125            
 Val Gln Ala Ser Pro Gly Ser Ser Pro Ser Met Gly Pro Arg Gly Ser
     130                 135                 140                
 Ser Val Ser Pro Pro Leu Ala Gly Gly Glu Ala Gly Leu Pro Thr Ser
 145                 150                 155                 160
 Gly Asn Pro Pro Asn Ser Ser Pro Trp Ala Ser Gly Gln Gly Gly Trp
                 165                 170                 175    
 Ala Ser Leu Ser Leu Thr Ser Leu Ser Ser Gln Leu Ser Gly Trp Met
             180                 185                 190        
 Ala Ala Ala Xaa Leu Gly Ser Phe Ser Ser Ser Ser Ser Phe Ser Trp
         195                 200                 205            
 Gly Thr Trp Leu Ser Pro Phe Val Ser Ser Ser Ile Thr Gly Ala Glu
     210                 215                 220                
 Ser Thr Gly Thr Ser Thr Asp Ala Val Ser Asn Phe Leu Ser Ala Phe
 225                 230                 235                 240
 Lys Glu Pro Glu Ala Val Met Gly Ser Gly Ser Ser Trp Ala Gly Ser
                 245                 250                 255    
 Ser Ser Ser Arg Val Pro Pro Asn Ser Ser Ser Asp Glu His Val Pro
             260                 265                 270        
 Gly Ser Pro Ala Val Ser Ser Val Ala Thr Gly Phe Thr Thr Gly Ser
         275                 280                 285            
 Ser Thr Leu Glu Ile Ile Thr Cys Ser Val Pro Ser Gly Gly Gly Leu
     290                 295                 300                
 Gly Pro Gly Arg Glu Arg Leu Ser Pro Leu Ala Asn Glu Leu Gly Thr
 305                 310                 315                 320
 Ser Gly Cys Phe Ser Ser Ser Asp Ser Trp Asn Thr Ser Leu Leu Arg
                 325                 330                 335    
 Val Ser Leu Pro Gly Thr Pro Gly Arg Met Ala Glu Ala Leu Leu Ala
             340                 345                 350        
 Gly Leu Ala Trp Phe Asp Pro Val Gly Gly Phe Arg Ser Val Lys Leu
         355                 360                 365            
 Asp Thr Leu Ser Leu Gly Lys Ala Met Leu Ser Ser Asn Lys Leu Cys
     370                 375                 380                
 Phe Phe Lys Ile Ala Ala Ser Phe Ile Thr Phe Arg Val Ser Ser Ser
 385                 390                 395                 400
 Arg Ile
        



      <210> 2442
      <211> 311
      <212> PRT
      <213> Homo sapiens


      <400> 2442
 Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala
   1               5                  10                  15    
 Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr
              20                  25                  30        
 Ala Thr Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp
          35                  40                  45            
 Leu Ser Val Ser Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe
      50                  55                  60                
 Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu
  65                  70                  75                  80
 Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn
                  85                  90                  95    
 Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser
             100                 105                 110        
 Ser Val Lys Val Gly Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg
         115                 120                 125            
 Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
     130                 135                 140                
 Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
 145                 150                 155                 160
 Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
                 165                 170                 175    
 Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro
             180                 185                 190        
 Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
         195                 200                 205            
 Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
     210                 215                 220                
 His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
 225                 230                 235                 240
 Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                 245                 250                 255    
 Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
             260                 265                 270        
 Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
         275                 280                 285            
 Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
     290                 295                 300                
 Lys Arg Lys Asp Ser Arg Gly
 305                 310    



      <210> 2443
      <211> 117
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(117)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2443
 Ser Arg Thr Pro Glu Asn Tyr Leu Lys Ser Ser Ile Asp Ser Ala His
   1               5                  10                  15    
 Arg Gln Lys Arg Lys Arg Thr Ile Pro Ser Ala Lys Gly Thr Phe Pro
              20                  25                  30        
 Gly Phe Phe Arg Ala Ala Lys Leu Leu Cys Gln Ser Leu Ser Pro Phe
          35                  40                  45            
 Met Thr Gly Arg Ala Pro Xaa Ala Leu Ala Gly Asp Thr Ser Ala Phe
      50                  55                  60                
 Met Ala Leu Leu Pro Arg Thr His Leu Ser Ala Thr Pro Ala Val Cys
  65                  70                  75                  80
 Pro Phe Pro Glu Thr Phe Ile Ser Ser Val Phe Val Ala Ser Leu Phe
                  85                  90                  95    
 Thr Ile Leu Glu Leu Lys Tyr His Leu Leu Arg Glu Ala Phe Pro Leu
             100                 105                 110        
 Leu Pro Ser Xaa Asn
         115        



      <210> 2444
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 2444
 Asp Ser Ser Arg Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys
   1               5                  10                  15    
 Gln Pro Pro Pro Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro
              20                  25                  30        
 Pro Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys Pro Gln Pro
          35                  40                  45            
 Cys Pro Pro Gln Gln Cys Gln Gln Lys Tyr Pro Pro Val Thr Pro Ser
      50                  55                  60                
 Pro Pro Cys Gln Ser Lys Tyr Pro Pro Lys Ser Lys
  65                  70                  75    



      <210> 2445
      <211> 949
      <212> PRT
      <213> Homo sapiens


      <400> 2445
 Thr Arg Thr Lys Arg Arg Leu Gly Arg Glu Lys Ala Met Ala Ser Pro
   1               5                  10                  15    
 Pro Arg Gly Trp Gly Cys Gly Glu Leu Leu Leu Pro Phe Met Leu Leu
              20                  25                  30        
 Gly Thr Leu Cys Glu Pro Gly Ser Gly Gln Ile Arg Tyr Ser Met Pro
          35                  40                  45            
 Glu Glu Leu Asp Lys Gly Ser Phe Val Gly Asn Ile Ala Lys Asp Leu
      50                  55                  60                
 Gly Leu Glu Pro Gln Glu Leu Ala Glu Arg Gly Val Arg Ile Val Ser
  65                  70                  75                  80
 Arg Gly Arg Thr Gln Leu Phe Ala Leu Asn Pro Arg Ser Gly Ser Leu
                  85                  90                  95    
 Val Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu Cys Ala Gln Ser Pro
             100                 105                 110        
 Leu Cys Val Val Asn Phe Asn Ile Leu Val Glu Asn Lys Met Lys Ile
         115                 120                 125            
 Tyr Gly Val Glu Val Glu Ile Ile Asp Ile Asn Asp Asn Phe Pro Arg
     130                 135                 140                
 Phe Arg Asp Glu Glu Leu Lys Val Lys Val Asn Glu Asn Ala Ala Ala
 145                 150                 155                 160
 Gly Thr Arg Leu Val Leu Pro Phe Ala Arg Asp Ala Asp Val Gly Val
                 165                 170                 175    
 Asn Ser Leu Arg Ser Tyr Gln Leu Ser Ser Asn Leu His Phe Ser Leu
             180                 185                 190        
 Asp Val Val Ser Gly Thr Asp Gly Gln Lys Tyr Pro Glu Leu Val Leu
         195                 200                 205            
 Glu Gln Pro Leu Asp Arg Glu Lys Glu Thr Val His Asp Leu Leu Leu
     210                 215                 220                
 Thr Ala Leu Asp Gly Gly Asp Pro Val Leu Ser Gly Thr Thr His Ile
 225                 230                 235                 240
 Arg Val Thr Val Leu Asp Ala Asn Asp Asn Ala Pro Leu Phe Thr Pro
                 245                 250                 255    
 Ser Glu Tyr Ser Val Ser Val Pro Glu Asn Ile Pro Val Gly Thr Arg
             260                 265                 270        
 Leu Leu Met Leu Thr Ala Thr Asp Pro Asp Glu Gly Ile Asn Gly Lys
         275                 280                 285            
 Leu Thr Tyr Ser Phe Arg Asn Glu Glu Glu Lys Ile Ser Glu Thr Phe
     290                 295                 300                
 Gln Leu Asp Ser Asn Leu Gly Glu Ile Ser Thr Leu Gln Ser Leu Asp
 305                 310                 315                 320
 Tyr Glu Glu Ser Arg Phe Tyr Leu Met Glu Val Val Ala Gln Asp Gly
                 325                 330                 335    
 Gly Ala Leu Val Ala Ser Ala Lys Val Val Val Thr Val Gln Asp Val
             340                 345                 350        
 Asn Asp Asn Ala Pro Glu Val Ile Leu Thr Ser Leu Thr Ser Ser Ile
         355                 360                 365            
 Ser Glu Asp Cys Leu Pro Gly Thr Val Ile Ala Leu Phe Ser Val His
     370                 375                 380                
 Asp Gly Asp Ser Gly Glu Asn Gly Glu Ile Ala Cys Ser Ile Pro Arg
 385                 390                 395                 400
 Asn Leu Pro Phe Lys Leu Glu Lys Ser Val Asp Asn Tyr Tyr His Leu
                 405                 410                 415    
 Leu Thr Thr Arg Asp Leu Asp Arg Glu Glu Thr Ser Asp Tyr Asn Ile
             420                 425                 430        
 Thr Leu Thr Val Met Asp His Gly Thr Pro Pro Leu Ser Thr Glu Ser
         435                 440                 445            
 His Ile Pro Leu Lys Val Ala Asp Val Asn Asp Asn Pro Pro Asn Phe
     450                 455                 460                
 Pro Gln Ala Ser Tyr Ser Thr Ser Val Thr Glu Asn Asn Pro Arg Gly
 465                 470                 475                 480
 Val Ser Ile Phe Ser Val Thr Ala His Asp Pro Asp Ser Gly Asp Asn
                 485                 490                 495    
 Ala Arg Val Thr Tyr Ser Leu Ala Glu Asp Thr Phe Gln Gly Ala Pro
             500                 505                 510        
 Leu Ser Ser Tyr Val Ser Ile Asn Ser Asp Thr Gly Val Leu Tyr Ala
         515                 520                 525            
 Leu Arg Ser Phe Asp Tyr Glu Gln Leu Arg Asp Leu Gln Leu Trp Val
     530                 535                 540                
 Thr Ala Ser Asp Ser Gly Asn Pro Pro Leu Ser Ser Asn Val Ser Leu
 545                 550                 555                 560
 Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Thr Pro Glu Ile Leu Tyr
                 565                 570                 575    
 Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu Leu Ala Pro Arg
             580                 585                 590        
 Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp Lys
         595                 600                 605            
 Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu Leu Lys Ala Ser
     610                 615                 620                
 Glu Pro Gly Leu Phe Ala Val Gly Leu His Thr Gly Glu Val Arg Thr
 625                 630                 635                 640
 Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln Ser Leu Val Val
                 645                 650                 655    
 Ala Val Glu Asp His Gly Gln Pro Pro Leu Ser Ala Thr Phe Thr Val
             660                 665                 670        
 Thr Val Ala Val Ala Asp Arg Ile Pro Asp Ile Leu Ala Asp Leu Gly
         675                 680                 685            
 Ser Ile Lys Thr Pro Ile Asp Pro Glu Asp Leu Asp Leu Thr Leu Tyr
     690                 695                 700                
 Leu Val Val Ala Val Ala Ala Val Ser Cys Val Phe Leu Ala Phe Val
 705                 710                 715                 720
 Ile Val Leu Leu Val Leu Arg Leu Arg Arg Trp His Lys Ser Arg Leu
                 725                 730                 735    
 Leu Gln Ala Glu Gly Ser Arg Leu Ala Gly Val Pro Ala Ser His Phe
             740                 745                 750        
 Val Gly Val Asp Gly Val Arg Ala Phe Leu Gln Thr Tyr Ser His Glu
         755                 760                 765            
 Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu Ile Phe Pro Gln
     770                 775                 780                
 Pro Asn Tyr Ala Asp Thr Leu Leu Ser Glu Glu Ser Cys Glu Lys Ser
 785                 790                 795                 800
 Glu Pro Leu Leu Met Ser Asp Lys Val Asp Ala Asn Lys Glu Glu Arg
                 805                 810                 815    
 Arg Val Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala
             820                 825                 830        
 Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr
         835                 840                 845            
 Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu
     850                 855                 860                
 Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly
 865                 870                 875                 880
 Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu
                 885                 890                 895    
 Gln His Val Leu Gln Gly Glu Leu Gly Ser Asp Tyr Arg Gln Asn Val
             900                 905                 910        
 Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg
         915                 920                 925            
 Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly
     930                 935                 940                
 Lys Lys Glu Lys Lys
 945                



      <210> 2446
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 2446
 Ala Asn Leu Gly Pro Thr Ala Pro Pro Arg Ser Gly Pro Val Leu Gly
   1               5                  10                  15    
 Ala Gly Glu Lys Gly Arg Gly Glu Met Arg Arg Ala Pro Phe Phe Leu
              20                  25                  30        
 Ser Ala Gly Gly Leu Glu Thr Pro Pro Pro Ser Ala Ala Leu Leu Trp
          35                  40                  45            
 Ala Pro Gly Arg Arg Ala Asp Glu Ile Ser Gly Leu
      50                  55                  60



      <210> 2447
      <211> 102
      <212> PRT
      <213> Homo sapiens


      <400> 2447
 Cys Gly Cys Gly Ser Cys Gly Gly Cys Gly Gly Arg Cys Gly Gly Gly
   1               5                  10                  15    
 Cys Gly Gly Gly Cys Ser Gly Gly Cys Gly Gly Gly Cys Gly Gly Gly
              20                  25                  30        
 Cys Gly Gly Gly Cys Gly Ser Cys Thr Thr Cys Arg Cys Tyr Arg Val
          35                  40                  45            
 Gly Cys Cys Ser Ser Cys Cys Pro Cys Cys Arg Gly Cys Cys Gly Gly
      50                  55                  60                
 Cys Cys Ser Thr Pro Val Ile Cys Cys Cys Arg Arg Thr Cys Gly Ser
  65                  70                  75                  80
 Cys Gly Cys Gly Tyr Gly Lys Gly Cys Cys Gln Gln Lys Cys Cys Cys
                  85                  90                  95    
 Gln Lys Gln Cys Cys Cys
             100        



      <210> 2448
      <211> 252
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(252)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2448
 Tyr Ala Lys Leu Gly Thr Arg Asp Pro Ser Lys Leu Cys Arg His Ser
   1               5                  10                  15    
 Leu Lys Cys Leu Glu Cys Asn Glu Val Phe Gln Asp Glu Thr Ser Leu
              20                  25                  30        
 Ala Thr His Phe Gln Gln Ala Ala Asp Thr Ser Gly Gln Gln Met Lys
          35                  40                  45            
 Lys His Pro Cys Arg Gln Cys Asp Lys Ser Phe Ser Ser Ser His Ser
      50                  55                  60                
 Leu Cys Arg His Asn Arg Ile Lys His Lys Gly Ile Arg Lys Val Tyr
  65                  70                  75                  80
 Ala Cys Ser His Cys Pro Asp Ser Arg Arg Thr Phe Thr Lys Arg Leu
                  85                  90                  95    
 Met Leu Glu Lys His Val Gln Leu Met His Gly Ile Lys Asp Pro Asp
             100                 105                 110        
 Leu Lys Glu Thr Asp Arg Cys His Gln Xaa Gly Gly Asn Arg Asn Lys
         115                 120                 125            
 Arg Arg His Xaa Gly Pro Gln Ser Gln Ala Glu Val Gly Arg Thr Ser
     130                 135                 140                
 Ser Gly Val Gln Ala Ser Pro Arg Ser Asn His Ser Thr Thr Glu Lys
 145                 150                 155                 160
 Ala Glu Asn Gln Phe Phe Lys Val His Lys Cys Ala Val Cys Gly Phe
                 165                 170                 175    
 Thr Thr Glu Asn Leu Leu Gln Phe His Glu His Ile Pro Gln His Lys
             180                 185                 190        
 Ser Asp Gly Ser Ser Tyr Gln Cys Arg Glu Cys Gly Leu Cys Tyr Thr
         195                 200                 205            
 Ser His Val Ser Leu Ser Arg His Leu Phe Ile Val His Lys Leu Lys
     210                 215                 220                
 Glu Pro Gln Pro Val Ser Lys Gln Asn Gly Ala Gly Glu Asp Asn Gln
 225                 230                 235                 240
 Gln Glu Asn Lys Pro Ser His Glu Gly Gly Ile Pro
                 245                 250        



      <210> 2449
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 2449
 Met Ile Glu Thr Trp Leu Trp Leu Leu Leu Leu Asn Val Gly Gly Thr
   1               5                  10                  15    
 Gly Gln Trp Ser Gly Pro Thr Phe Arg Arg Glu Asn Val Leu Pro Ala
              20                  25                  30        
 Ala His Ile Gly Pro Lys Tyr Gly Pro Leu Leu Pro Ser Thr Ala Lys
          35                  40                  45            
 Gly Thr Val Lys Val Ser Cys Pro Ser Ser Thr Pro His Pro Pro Leu
      50                  55                  60                
 Gln Gly Lys Gly Thr Pro Asp
  65                  70    



      <210> 2450
      <211> 47
      <212> PRT
      <213> Homo sapiens


      <400> 2450
 Met Ser Leu Leu Leu Pro Pro Leu Ala Leu Leu Leu Leu Leu Ala Ala
   1               5                  10                  15    
 Leu Val Ala Pro Ala Thr Ala Ala Thr Ala Tyr Arg Pro Asp Trp Asn
              20                  25                  30        
 Arg Leu Ser Gly Leu Thr Arg Ala Arg Val Glu Thr Cys Gly Gly
          35                  40                  45        



      <210> 2451
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 2451
 Lys Leu Ile Leu Leu Lys Ile Gln Tyr Phe Asn Leu Leu Met Lys Cys
   1               5                  10                  15    
 Cys Phe Arg Ile Lys Gly Lys Leu Glu Glu Gln Arg Pro Glu Arg Val
              20                  25                  30        
 Lys Pro Phe Met Thr Gly Ala Ala Glu Gln Ile Lys His Ile Leu Ala
          35                  40                  45            
 Asn Phe Lys Asn Tyr Gln Val Asn Thr Leu Ser Ile Trp Ile Lys Gly
      50                  55                  60                
 Leu Tyr Asn Phe Asn Cys Lys Ser Lys Asn
  65                  70                



      <210> 2452
      <211> 218
      <212> PRT
      <213> Homo sapiens


      <400> 2452
 Leu Pro Gly Arg Pro Thr Arg Ala Pro Thr Arg Pro Ala Glu His Ser
   1               5                  10                  15    
 Ile Val Gly Thr Arg Leu Val Ser Cys Gln Leu Gln Pro Ser Gln Pro
              20                  25                  30        
 Asn Ala Asp Gln Gly Lys Leu Thr Thr Met Arg Ile Ala Val Ile Cys
          35                  40                  45            
 Phe Cys Leu Leu Gly Ile Thr Cys Ala Ile Pro Val Lys Gln Ala Asp
      50                  55                  60                
 Ser Gly Ser Ser Glu Glu Lys Gln Leu Tyr Asn Lys Tyr Pro Asp Ala
  65                  70                  75                  80
 Val Ala Thr Trp Leu Asn Pro Asp Pro Ser Gln Lys Gln Asn Leu Leu
                  85                  90                  95    
 Ala Pro Gln Thr Leu Pro Ser Lys Ser Asn Glu Ser His Asp His Met
             100                 105                 110        
 Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His Val Asp Ser Gln Asp
         115                 120                 125            
 Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp Asp Thr Asp Asp Ser
     130                 135                 140                
 His Gln Ser Asp Glu Ser His His Ser Asp Glu Ser Asp Glu Leu Val
 145                 150                 155                 160
 Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu Val Phe Thr Pro Val
                 165                 170                 175    
 Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr
             180                 185                 190        
 Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr
         195                 200                 205            
 Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser
     210                 215            



      <210> 2453
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 2453
 Ile Gln Gly Met His Phe Ala Ala Gly Arg Leu Ser Thr Lys Thr Phe
   1               5                  10                  15    
 Cys Thr Gly His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg
              20                  25                  30        
 Asp Ile Pro Met Asn Pro Met Gly Ile Tyr Arg Ser Pro Glu Lys Lys
          35                  40                  45            
 Ala Thr Glu Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn
      50                  55                  60                
 Arg Arg Asp Val Glu Pro Thr Lys Ala Asn Ser Arg Phe Ala Thr Thr
  65                  70                  75                  80
 Phe Tyr Gln His Leu Ala Asp Ser Lys Asn Asp Asn Asp
                  85                  90            



      <210> 2454
      <211> 1621
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1621)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2454
 Met Ala Lys Ser Gly Gly Cys Gly Ala Gly Ala Gly Val Gly Gly Gly
   1               5                  10                  15    
 Asn Gly Ala Leu Thr Trp Val Asn Asn Ala Ala Lys Lys Glu Glu Ser
              20                  25                  30        
 Glu Thr Ala Asn Lys Asn Asp Ser Ser Lys Lys Leu Ser Val Glu Arg
          35                  40                  45            
 Val Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp
      50                  55                  60                
 Thr Tyr Ile Gly Ser Val Glu Pro Leu Thr Gln Phe Met Trp Val Tyr
  65                  70                  75                  80
 Asp Glu Asp Val Gly Met Asn Cys Arg Glu Val Thr Phe Val Pro Gly
                  85                  90                  95    
 Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys
             100                 105                 110        
 Gln Arg Asp Lys Asn Met Thr Cys Ile Lys Val Ser Ile Asp Pro Glu
         115                 120                 125            
 Ser Asn Ile Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val
     130                 135                 140                
 Glu His Lys Val Glu Lys Val Tyr Val Pro Ala Leu Ile Phe Gly Gln
 145                 150                 155                 160
 Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly
                 165                 170                 175    
 Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys
             180                 185                 190        
 Phe Thr Val Glu Thr Ala Cys Lys Glu Tyr Lys His Ser Phe Lys Gln
         195                 200                 205            
 Thr Trp Met Asn Asn Met Met Lys Thr Ser Glu Ala Lys Ile Lys His
     210                 215                 220                
 Phe Asp Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser
 225                 230                 235                 240
 Lys Phe Lys Met Glu Lys Leu Asp Lys Asp Ile Val Ala Leu Met Thr
                 245                 250                 255    
 Arg Arg Ala Tyr Asp Leu Ala Gly Ser Cys Arg Gly Val Lys Val Met
             260                 265                 270        
 Phe Asn Gly Lys Lys Leu Pro Val Asn Gly Phe Arg Ser Tyr Val Asp
         275                 280                 285            
 Leu Tyr Val Lys Asp Lys Leu Asp Glu Thr Gly Val Ala Leu Lys Val
     290                 295                 300                
 Ile His Glu Leu Ala Asn Glu Arg Trp Asp Val Cys Leu Thr Leu Ser
 305                 310                 315                 320
 Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Thr
                 325                 330                 335    
 Lys Gly Gly Arg His Val Asp Tyr Val Val Asp Gln Val Val Gly Lys
             340                 345                 350        
 Leu Ile Glu Val Val Lys Lys Lys Asn Lys Ala Gly Val Ser Val Lys
         355                 360                 365            
 Pro Phe Gln Val Lys Asn His Ile Trp Val Phe Ile Asn Cys Leu Ile
     370                 375                 380                
 Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met Thr Leu Gln
 385                 390                 395                 400
 Pro Lys Ser Phe Gly Ser Lys Cys Gln Leu Ser Glu Lys Phe Phe Lys
                 405                 410                 415    
 Ala Ala Ser Asn Cys Gly Ile Val Glu Ser Ile Leu Asn Trp Val Lys
             420                 425                 430        
 Phe Lys Ala Gln Thr Gln Leu Asn Lys Lys Cys Ser Ser Val Lys Tyr
         435                 440                 445            
 Ser Lys Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala Asn Asp Ala Gly
     450                 455                 460                
 Gly Lys His Ser Leu Glu Cys Thr Leu Ile Leu Thr Glu Gly Asp Ser
 465                 470                 475                 480
 Ala Lys Ser Leu Ala Val Ser Gly Leu Gly Val Ile Gly Arg Asp Arg
                 485                 490                 495    
 Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn Val Arg Glu Ala
             500                 505                 510        
 Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile Asn Asn Ile Ile Lys
         515                 520                 525            
 Ile Val Gly Leu Gln Tyr Lys Lys Ser Tyr Asp Asp Ala Gln Ser Leu
     530                 535                 540                
 Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met Thr Asp Gln Asp Gln
 545                 550                 555                 560
 Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn Phe Ile His His Asn
                 565                 570                 575    
 Trp Pro Ser Leu Leu Lys His Gly Phe Leu Glu Glu Phe Ile Thr Pro
             580                 585                 590        
 Ile Val Lys Ala Ser Lys Asn Lys Gln Glu Leu Ser Phe Tyr Ser Ile
         595                 600                 605            
 Pro Glu Phe Asp Glu Trp Lys Lys His Ile Glu Asn Gln Lys Ala Trp
     610                 615                 620                
 Lys Ile Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr Ala Lys Glu Ala
 625                 630                 635                 640
 Lys Glu Tyr Phe Ala Asp Met Glu Arg His Arg Ile Leu Phe Arg Tyr
                 645                 650                 655    
 Ala Gly Pro Glu Asp Asp Ala Ala Ile Thr Leu Ala Phe Ser Lys Lys
             660                 665                 670        
 Lys Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe Met Glu Asp Arg
         675                 680                 685            
 Arg Gln Arg Arg Leu His Gly Leu Pro Glu Gln Phe Leu Tyr Gly Thr
     690                 695                 700                
 Ala Thr Lys His Leu Thr Tyr Asn Asp Phe Ile Asn Lys Glu Leu Ile
 705                 710                 715                 720
 Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro Ser Leu Val Asp
                 725                 730                 735    
 Gly Phe Lys Pro Gly Gln Arg Lys Val Leu Phe Thr Cys Phe Lys Arg
             740                 745                 750        
 Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu Ala Gly Ser Val Ala
         755                 760                 765            
 Glu Met Ser Ala Tyr His His Gly Glu Gln Ala Leu Met Met Thr Ile
     770                 775                 780                
 Val Asn Leu Ala Gln Asn Phe Val Gly Ser Asn Asn Ile Asn Leu Leu
 785                 790                 795                 800
 Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His Gly Gly Lys Asp Ala
                 805                 810                 815    
 Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser Thr Leu Ala Arg Leu
             820                 825                 830        
 Leu Phe Pro Ala Val Asp Asp Asn Leu Leu Lys Phe Leu Tyr Asp Asp
         835                 840                 845            
 Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile Ile Pro Met Val
     850                 855                 860                
 Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp Ala Cys Lys Leu
 865                 870                 875                 880
 Pro Asn Tyr Asp Ala Arg Glu Ile Val Asn Asn Val Arg Arg Met Leu
                 885                 890                 895    
 Asp Gly Leu Asp Pro His Pro Met Leu Pro Asn Tyr Lys Asn Phe Lys
             900                 905                 910        
 Gly Thr Ile Gln Glu Leu Gly Gln Asn Gln Tyr Ala Val Ser Gly Glu
         915                 920                 925            
 Ile Phe Val Val Asp Arg Asn Thr Val Glu Ile Thr Glu Leu Pro Val
     930                 935                 940                
 Arg Thr Trp Thr Gln Val Tyr Lys Glu Gln Val Leu Glu Pro Met Leu
 945                 950                 955                 960
 Asn Gly Thr Asp Lys Thr Pro Ala Leu Ile Ser Asp Tyr Lys Glu Tyr
                 965                 970                 975    
 His Thr Asp Thr Thr Val Lys Phe Val Val Lys Met Thr Glu Glu Lys
             980                 985                 990        
 Leu Ala Gln Ala Glu Ala Ala Gly Leu His Lys Val Phe Lys Leu Gln
         995                1000                1005            
 Thr Thr Leu Thr Cys Asn Ser Met Val Leu Phe Asp His Met Gly Cys
    1010                1015                1020                
 Leu Lys Lys Tyr Glu Thr Val Gln Asp Ile Leu Lys Glu Phe Phe Asp
1025                1030                1035                1040
 Leu Arg Leu Ser Tyr Tyr Gly Leu Arg Lys Glu Trp Leu Val Gly Met
                1045                1050                1055    
 Leu Gly Ala Glu Phe Thr Lys Leu Asn Asn Gln Ala Arg Phe Ile Leu
            1060                1065                1070        
 Glu Lys Ile Gln Gly Lys Ile Thr Ile Xaa Asn Arg Ser Lys Lys Asp
        1075                1080                1085            
 Leu Ile Gln Met Leu Val Gln Arg Gly Tyr Glu Ser Asp Pro Val Lys
    1090                1095                1100                
 Ala Trp Lys Glu Ala Gln Glu Lys Ala Ala Glu Glu Asp Glu Thr Gln
1105                1110                1115                1120
 Asn Gln His Asp Asp Ser Ser Ser Asp Ser Gly Thr Pro Ser Gly Pro
                1125                1130                1135    
 Asp Phe Asn Tyr Ile Leu Asn Met Ser Leu Trp Ser Leu Thr Lys Glu
            1140                1145                1150        
 Lys Val Glu Glu Leu Ile Lys Gln Arg Asp Ala Lys Gly Arg Glu Val
        1155                1160                1165            
 Asn Asp Leu Lys Arg Lys Ser Pro Ser Asp Leu Trp Lys Glu Asp Leu
    1170                1175                1180                
 Ala Ala Phe Val Glu Glu Leu Asp Lys Val Glu Ser Gln Glu Arg Glu
1185                1190                1195                1200
 Asp Val Leu Ala Gly Met Ser Gly Lys Ala Ile Lys Gly Lys Val Gly
                1205                1210                1215    
 Lys Pro Lys Val Lys Lys Leu Gln Leu Glu Glu Thr Met Pro Ser Pro
            1220                1225                1230        
 Tyr Gly Arg Arg Ile Ile Pro Glu Ile Thr Ala Met Lys Ala Asp Ala
        1235                1240                1245            
 Ser Lys Lys Leu Leu Lys Lys Lys Lys Gly Asp Leu Asp Thr Ala Ala
    1250                1255                1260                
 Val Lys Val Glu Phe Asp Glu Glu Phe Ser Gly Ala Pro Val Glu Gly
1265                1270                1275                1280
 Ala Gly Glu Glu Ala Leu Thr Pro Ser Val Pro Ile Asn Lys Gly Pro
                1285                1290                1295    
 Lys Pro Lys Arg Glu Lys Lys Glu Pro Gly Thr Arg Val Arg Lys Thr
            1300                1305                1310        
 Pro Thr Ser Ser Gly Lys Pro Ser Ala Lys Lys Val Lys Lys Arg Asn
        1315                1320                1325            
 Pro Trp Ser Asp Asp Glu Ser Lys Ser Glu Ser Asp Leu Glu Glu Thr
    1330                1335                1340                
 Glu Pro Val Val Ile Pro Arg Asp Ser Leu Leu Arg Arg Ala Ala Ala
1345                1350                1355                1360
 Glu Arg Pro Lys Tyr Thr Phe Asp Phe Ser Glu Glu Glu Asp Asp Asp
                1365                1370                1375    
 Ala Asp Asp Asp Asp Asp Asp Asn Asn Asp Leu Glu Glu Leu Lys Val
            1380                1385                1390        
 Lys Ala Ser Pro Ile Thr Asn Asp Gly Glu Asp Glu Phe Val Pro Ser
        1395                1400                1405            
 Asp Gly Leu Asp Lys Asp Glu Tyr Thr Phe Ser Pro Gly Lys Ser Lys
    1410                1415                1420                
 Ala Thr Pro Glu Lys Ser Leu His Asp Lys Lys Ser Gln Asp Phe Gly
1425                1430                1435                1440
 Asn Leu Phe Ser Phe Pro Ser Tyr Ser Gln Lys Ser Glu Asp Asp Ser
                1445                1450                1455    
 Ala Lys Phe Asp Ser Asn Glu Glu Asp Ser Ala Ser Val Phe Ser Pro
            1460                1465                1470        
 Ser Phe Gly Leu Lys Gln Thr Asp Lys Val Pro Ser Lys Thr Val Ala
        1475                1480                1485            
 Ala Lys Lys Gly Lys Pro Ser Ser Asp Thr Val Pro Lys Pro Lys Arg
    1490                1495                1500                
 Ala Pro Lys Gln Lys Lys Val Val Glu Ala Val Asn Ser Asp Ser Asp
1505                1510                1515                1520
 Ser Glu Phe Gly Ile Pro Lys Lys Thr Thr Thr Pro Lys Gly Lys Gly
                1525                1530                1535    
 Arg Gly Ala Lys Lys Arg Lys Ala Ser Gly Ser Glu Asn Glu Gly Asp
            1540                1545                1550        
 Tyr Asn Pro Gly Arg Lys Thr Ser Lys Thr Thr Ser Lys Lys Pro Lys
        1555                1560                1565            
 Lys Thr Ser Phe Asp Gln Asp Ser Asp Val Asp Ile Phe Pro Ser Asp
    1570                1575                1580                
 Phe Pro Thr Glu Pro Pro Ser Leu Pro Arg Thr Gly Arg Ala Arg Lys
1585                1590                1595                1600
 Glu Val Lys Tyr Phe Ala Glu Ser Asp Glu Glu Glu Asp Asp Val Asp
                1605                1610                1615    
 Phe Ala Met Phe Asn
            1620    



      <210> 2455
      <211> 50
      <212> PRT
      <213> Homo sapiens


      <400> 2455
 Phe Lys Ile Gln Lys Thr Arg Leu Gln Arg Glu Gly Phe Asp Pro Arg
   1               5                  10                  15    
 Gln Thr Ser Asp Arg Leu Phe Phe Leu Asp Leu Lys Gln Gly His Tyr
              20                  25                  30        
 Leu Pro Leu Asn Glu Ala Val Tyr Thr Arg Ile Cys Ser Gly Ala Phe
          35                  40                  45            
 Ala Leu
      50



      <210> 2456
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 2456
 Phe Gln Gly Gln Arg Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu
   1               5                  10                  15    
 Leu Glu Gln Phe Ile Leu Leu Ala Lys Gly Thr Ser Gly Ser Ala Leu
              20                  25                  30        
 Thr Ala Leu Ile Ser Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe
          35                  40                  45            
 Gly Glu Leu Leu Glu Leu Ala Asn Val Gln Glu Leu Ala Glu Gly Ala
      50                  55                  60                
 Asn Ala Ala Tyr Leu Gln Leu Leu Asn Leu Phe Ala Tyr Gly Thr Tyr
  65                  70                  75                  80
 Pro Asp Tyr Ile Ala Asn Lys Glu Ser Leu Pro Glu Leu Tyr
                  85                  90                



      <210> 2457
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 2457
 Glu Ser Arg Glu Arg Ser Gly Asn Arg Arg Gly Ala Glu Asp Arg Gly
   1               5                  10                  15    
 Thr Cys Gly Leu Gln Ser Pro Ser Ala Met Leu Gly Ala Lys Pro His
              20                  25                  30        
 Trp Leu Pro Gly Pro Leu His Ser Pro Gly Leu Pro Leu Val Leu Val
          35                  40                  45            
 Leu Leu Ala Leu Gly Ala Gly Trp Ala Gln Glu Gly Ser Glu Pro Val
      50                  55                  60                
 Leu Leu Glu Gly Glu Cys Leu Val Val Cys Glu Pro Gly Arg Ala Ala
  65                  70                  75                  80
 Ala Gly Gly Pro Gly Gly Ala Ala Leu Gly Glu Ala Pro Pro Gly Arg
                  85                  90                  95    
 Val Ala Phe Ala Ala Val Arg Ser His His His Glu Pro Ala Gly Glu
             100                 105                 110        
 Thr Gly Asn Gly Thr Ser Gly Ala Ile Tyr Phe Asp Gln Val Leu Val
         115                 120                 125            
 Asn Glu Gly Gly Gly Phe Asp Arg Ala Ser
     130                 135            



      <210> 2458
      <211> 124
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(124)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2458
 Gly Arg Gly Val Cys Val Ala Ala Trp Ser Gln Arg Ser Ile Ala Gly
   1               5                  10                  15    
 Asn Asn Asp Tyr Arg Leu Phe His Lys Met Ser Asn Ser His Pro Leu
              20                  25                  30        
 Arg Pro Phe Thr Ala Val Gly Glu Ile Asp His Val His Ile Leu Ser
          35                  40                  45            
 Glu His Ile Cys Ala Leu Leu Ile Gly Glu Glu Tyr Gly Asp Val Thr
      50                  55                  60                
 Phe Val Gly Glu Lys Lys Arg Phe Pro Ala His Arg Val Ile Leu Ala
  65                  70                  75                  80
 Ala Arg Cys Gln Tyr Phe Arg Ala Leu Leu Tyr Gly Gly Met Arg Glu
                  85                  90                  95    
 Ser Gln Pro Glu Ala Glu Ile Pro Leu Gln Asp Thr Thr Ala Glu Ala
             100                 105                 110        
 Phe Thr Met Leu Leu Xaa Tyr Ile Tyr Thr Gly Arg
         115                 120                



      <210> 2459
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 2459
 Met Cys Thr Lys Thr Ile Pro Val Leu Trp Gly Cys Phe Leu Leu Trp
   1               5                  10                  15    
 Asn Leu Tyr Val Ser Ser Ser Gln Thr Ile Tyr Pro Gly Ile Lys Ala
              20                  25                  30        
 Arg Ile Thr Gln Arg Ala Leu Asp Tyr Gly Val Gln Ala Gly Met Lys
          35                  40                  45            
 Met Ile Glu Gln Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly
      50                  55                  60                
 Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe
  65                  70                  75                  80
 Ser Asn Ile Lys Ile Ser Ala Phe Ser Phe Pro Asn Thr Ser Leu Ala
                  85                  90                  95    
 Phe Val Pro Gly Val Gly Ile
             100            



      <210> 2460
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 2460
 Met Cys Thr Lys Thr Ile Pro Val Leu Trp Gly Cys Phe Leu Leu Trp
   1               5                  10                  15    
 Asn Leu Tyr Val Ser Ser Ser Gln Thr Ile Tyr Pro Gly Ile Lys Ala
              20                  25                  30        
 Arg Ile Thr Gln Arg Ala Leu Asp Tyr Gly Val Gln Ala Gly Met Lys
          35                  40                  45            
 Met Ile Glu Gln Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly
      50                  55                  60                
 Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe
  65                  70                  75                  80
 Ser Asn Ile Lys Ile Ser Ala Phe Ser Phe Pro Asn Thr Ser Leu Ala
                  85                  90                  95    
 Phe Val Pro Gly Val Gly Ile
             100            



      <210> 2461
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 2461
 Met Cys Thr Lys Thr Ile Pro Val Leu Trp Gly Cys Phe Leu Leu Trp
   1               5                  10                  15    
 Asn Leu Tyr Val Ser Ser Ser Gln Thr Ile Tyr Pro Gly Ile Lys Ala
              20                  25                  30        
 Arg Ile Thr Gln Arg Ala Leu Asp Tyr Gly Val Gln Ala Gly Met Lys
          35                  40                  45            
 Met Ile Glu Gln Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly
      50                  55                  60                
 Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe
  65                  70                  75                  80
 Ser Asn Ile Lys Ile Ser Ala Phe Ser Phe Pro Asn Thr Ser Leu Ala
                  85                  90                  95    
 Phe Val Pro Gly Val Gly Ile
             100            



      <210> 2462
      <211> 351
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(351)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2462
 Glu Glu Glu Gln Glu Cys Arg Pro Ala Ile Lys Thr Ser Asp Ile Asp
   1               5                  10                  15    
 Asn Pro Ser His Phe Glu Lys Gln Tyr Glu Ser Ser Ser Ser Ser Thr
              20                  25                  30        
 His Ser Asp Arg Ser Ser Asp Gly Glu Gln Asp Phe Val Ser Ser Ile
          35                  40                  45            
 Leu Pro Gly Asn Arg Pro Asn Ser Thr Asn Ile Lys Pro Gln Leu His
      50                  55                  60                
 Gln Lys Ser Ile Met Lys Lys Lys Ala Gly His Lys Ala Asn Ser Lys
  65                  70                  75                  80
 His Xaa Asp Xaa Glu Gln Thr Val Val Asp Val Thr Glu Gln Leu Gly
                  85                  90                  95    
 Asp Cys Lys Leu Asp Ser Gln Glu Lys Asp Ala Thr Cys Glu Leu Pro
             100                 105                 110        
 Leu Gln Lys Val Asn Thr Gln Ser Ser Ser Asn Ser Thr Leu Pro Gly
         115                 120                 125            
 Arg Leu Lys Ala Ser Glu Asn Ser Glu Ser Glu Tyr Ser Arg Ser Glu
     130                 135                 140                
 Ile Thr Leu Val Gly Ile Ser Lys Lys Ser Ala Glu His Phe Lys Arg
 145                 150                 155                 160
 Lys Phe Ala Lys Ser Asn Gln Val Ser Arg Ser Val Ser Ser Ser Val
                 165                 170                 175    
 Gln Val Cys Pro Glu Val Gly Lys Arg Asn Leu Leu Lys Val Leu Lys
             180                 185                 190        
 Glu Thr Leu Ile Glu Trp Lys Thr Glu Glu Thr Leu Arg Phe Leu Tyr
         195                 200                 205            
 Gly Gln Asn Tyr Ala Ser Val Cys Leu Lys Pro Glu Ala Ser Leu Val
     210                 215                 220                
 Lys Glu Glu Leu Asp Glu Asp Asp Ile Ile Ser Asp Pro Asp Ser His
 225                 230                 235                 240
 Phe Pro Ala Trp Arg Glu Ser Gln Asn Ser Leu Asp Glu Ser Leu Pro
                 245                 250                 255    
 Phe Arg Gly Ser Gly Thr Ala Ile Lys Pro Leu Pro Ser Tyr Glu Asn
             260                 265                 270        
 Leu Lys Lys Glu Thr Glu Lys Leu Asn Leu Arg Ile Arg Glu Phe Tyr
         275                 280                 285            
 Arg Gly Arg Tyr Val Leu Gly Glu Glu Thr Thr Lys Ser Gln Asp Ser
     290                 295                 300                
 Glu Glu His Asp Ser Thr Phe Pro Leu Ile Asp Ser Ser Ser Gln Asn
 305                 310                 315                 320
 Gln Ile Arg Lys Arg Ile Val Leu Glu Lys Leu Ser Lys Val Leu Pro
                 325                 330                 335    
 Gly Leu Leu Val Pro Leu Gln Ile Thr Leu Gly Asp Ile Tyr Thr
             340                 345                 350    



      <210> 2463
      <211> 68
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(68)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2463
 Met Tyr Ile Lys Ile Lys Pro Arg Ser Phe Gly Ile Ile His Asn Leu
   1               5                  10                  15    
 Pro Ser Lys Pro Gly Pro Leu Phe Leu Pro His Ser Leu Ile Gly Trp
              20                  25                  30        
 Phe Asp Phe Thr Ala Ser Phe Leu Tyr Pro Met Asn Cys Ser Ala Met
          35                  40                  45            
 His His Xaa Val Arg Lys Ser Ser Ser Ala Thr Ala Ile Thr Lys Ile
      50                  55                  60                
 Gly Lys Thr Gly
  65            



      <210> 2464
      <211> 43
      <212> PRT
      <213> Homo sapiens


      <400> 2464
 Arg Leu Cys Asp Gly Leu Phe Pro Gln Gln Asp Pro Ala Ala Pro Ala
   1               5                  10                  15    
 Pro Cys Glu Glu Thr Gln Leu Ser Leu Leu Pro Leu Gln Gly Cys Gly
              20                  25                  30        
 Leu Met Glu Gly Lys Thr Met Glu Ala Lys Thr
          35                  40            



      <210> 2465
      <211> 469
      <212> PRT
      <213> Homo sapiens


      <400> 2465
 Gln Glu Thr Ser Lys Met Glu Thr Leu Ser Phe Pro Arg Tyr Asn Val
   1               5                  10                  15    
 Ala Glu Ile Val Ile His Ile Arg Asn Lys Ile Leu Thr Gly Ala Asp
              20                  25                  30        
 Gly Lys Asn Leu Thr Lys Asn Asp Leu Tyr Pro Asn Pro Lys Pro Glu
          35                  40                  45            
 Val Leu His Met Ile Tyr Met Arg Ala Leu Gln Ile Val Tyr Gly Ile
      50                  55                  60                
 Arg Leu Glu His Phe Tyr Met Met Pro Val Asn Ser Glu Val Met Tyr
  65                  70                  75                  80
 Pro His Leu Met Glu Gly Phe Leu Pro Phe Ser Asn Leu Val Thr His
                  85                  90                  95    
 Leu Asp Ser Phe Leu Pro Ile Cys Arg Val Asn Asp Phe Glu Thr Ala
             100                 105                 110        
 Asp Ile Leu Cys Pro Lys Ala Lys Arg Thr Ser Arg Phe Leu Ser Gly
         115                 120                 125            
 Ile Ile Asn Phe Ile His Phe Arg Glu Ala Cys Arg Glu Thr Tyr Met
     130                 135                 140                
 Glu Phe Leu Trp Gln Tyr Lys Ser Ser Ala Asp Lys Met Gln Gln Leu
 145                 150                 155                 160
 Asn Ala Ala His Gln Glu Ala Leu Met Lys Leu Glu Arg Leu Asp Ser
                 165                 170                 175    
 Val Pro Val Glu Glu Gln Glu Glu Phe Lys Gln Leu Ser Asp Gly Ile
             180                 185                 190        
 Gln Glu Leu Gln Gln Ser Leu Asn Gln Asp Phe His Gln Lys Thr Ile
         195                 200                 205            
 Val Leu Gln Glu Gly Asn Ser Gln Lys Lys Ser Asn Ile Ser Glu Lys
     210                 215                 220                
 Thr Lys Arg Leu Asn Glu Leu Lys Leu Ser Val Val Ser Leu Lys Glu
 225                 230                 235                 240
 Ile Gln Glu Ser Leu Lys Thr Lys Ile Val Asp Ser Pro Glu Lys Leu
                 245                 250                 255    
 Lys Asn Tyr Lys Glu Lys Met Lys Asp Thr Val Gln Lys Leu Lys Asn
             260                 265                 270        
 Ala Arg Gln Glu Val Val Glu Lys Tyr Glu Ile Tyr Gly Asp Ser Val
         275                 280                 285            
 Asp Cys Leu Pro Ser Cys Gln Leu Glu Val Gln Leu Tyr Gln Lys Lys
     290                 295                 300                
 Ile Gln Asp Leu Ser Asp Asn Arg Glu Lys Leu Ala Ser Ile Leu Lys
 305                 310                 315                 320
 Glu Ser Leu Asn Leu Glu Asp Gln Ile Glu Ser Asp Glu Ser Glu Leu
                 325                 330                 335    
 Lys Lys Leu Lys Thr Glu Glu Asn Ser Phe Lys Arg Leu Met Ile Val
             340                 345                 350        
 Lys Lys Glu Lys Leu Ala Thr Ala Gln Phe Lys Ile Asn Lys Lys His
         355                 360                 365            
 Glu Asp Val Lys Gln Tyr Lys Arg Thr Val Ile Glu Asp Cys Asn Lys
     370                 375                 380                
 Val Gln Glu Lys Arg Gly Ala Val Tyr Glu Arg Val Thr Thr Ile Asn
 385                 390                 395                 400
 His Glu Ile Gln Lys Ile Arg Leu Gly Ile Gln Gln Leu Lys Asp Ala
                 405                 410                 415    
 Ala Asp Arg Glu Lys Leu Lys Ser Gln Glu Ile Phe Leu Asn Leu Lys
             420                 425                 430        
 Thr Ala Leu Glu Lys Tyr His Asp Gly Ile Glu Lys Ala Ala Glu Asp
         435                 440                 445            
 Ser Tyr Ala Lys Ile Asp Glu Lys Thr Ala Glu Leu Lys Arg Lys Met
     450                 455                 460                
 Phe Lys Met Ser Thr
 465                



      <210> 2466
      <211> 694
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(694)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2466
 Gly Met Gly Ser Glu Asn Ser Ala Leu Lys Ser Tyr Thr Leu Arg Glu
   1               5                  10                  15    
 Pro Pro Phe Thr Leu Pro Ser Gly Leu Ala Val Tyr Pro Ala Val Leu
              20                  25                  30        
 Gln Asp Gly Lys Phe Ala Ser Val Phe Val Tyr Lys Arg Glu Asn Glu
          35                  40                  45            
 Asp Lys Val Asn Lys Ala Ala Lys Val Pro Xaa Xaa His Leu Lys Thr
      50                  55                  60                
 Leu Arg His Pro Cys Leu Leu Arg Phe Leu Ser Cys Thr Val Glu Ala
  65                  70                  75                  80
 Asp Gly Ile His Leu Val Thr Glu Arg Val Gln Pro Leu Glu Val Ala
                  85                  90                  95    
 Leu Glu Thr Leu Ser Ser Ala Glu Val Cys Ala Gly Ile Tyr Asp Ile
             100                 105                 110        
 Leu Leu Ala Leu Ile Phe Leu His Asp Arg Gly His Leu Thr His Asn
         115                 120                 125            
 Asn Val Cys Leu Ser Ser Val Phe Val Ser Glu Asp Gly His Trp Lys
     130                 135                 140                
 Leu Gly Gly Met Glu Thr Val Cys Lys Val Ser Gln Ala Thr Pro Glu
 145                 150                 155                 160
 Phe Leu Arg Ser Ile Gln Ser Ile Arg Asp Pro Ala Ser Ile Pro Pro
                 165                 170                 175    
 Glu Glu Met Ser Pro Glu Phe Thr Thr Leu Pro Glu Cys His Gly His
             180                 185                 190        
 Ala Arg Asp Ala Phe Ser Phe Gly Thr Leu Val Glu Ser Leu Leu Thr
         195                 200                 205            
 Ile Leu Asn Glu Gln Val Ser Ala Asp Val Leu Ser Ser Phe Gln Gln
     210                 215                 220                
 Thr Leu His Ser Thr Leu Leu Asn Pro Ile Pro Lys Trp Arg Pro Ala
 225                 230                 235                 240
 Leu Cys Thr Leu Leu Ser His Asp Phe Phe Arg Asn Asp Phe Leu Glu
                 245                 250                 255    
 Val Val Asn Phe Leu Lys Ser Leu Thr Leu Lys Ser Glu Glu Glu Lys
             260                 265                 270        
 Thr Glu Phe Phe Lys Phe Leu Leu Asp Arg Val Ser Cys Leu Ser Glu
         275                 280                 285            
 Glu Leu Ile Ala Ser Arg Leu Val Pro Leu Leu Leu Asn Gln Leu Val
     290                 295                 300                
 Phe Ala Glu Pro Val Ala Val Lys Ser Phe Leu Pro Tyr Leu Leu Gly
 305                 310                 315                 320
 Pro Lys Lys Asp His Ala Gln Gly Glu Thr Pro Cys Leu Leu Ser Pro
                 325                 330                 335    
 Ala Leu Phe Gln Ser Arg Val Ile Pro Val Leu Leu Gln Leu Phe Glu
             340                 345                 350        
 Val His Glu Glu His Val Arg Met Val Leu Leu Ser His Ile Glu Ala
         355                 360                 365            
 Tyr Val Gly Ala Leu Ser Leu Arg Glu Gln Leu Lys Lys Val Ile Leu
     370                 375                 380                
 Pro Gln Val Leu Leu Gly Leu Arg Asp Thr Ser Asp Ser Ile Val Ala
 385                 390                 395                 400
 Ile Thr Leu His Ser Leu Ala Val Leu Val Ser Leu Leu Gly Pro Glu
                 405                 410                 415    
 Val Val Val Gly Gly Glu Arg Thr Lys Ile Phe Lys Arg Thr Ala Pro
             420                 425                 430        
 Ser Phe Thr Lys Asn Thr Asp Leu Ser Leu Glu Gly Asp Pro Phe Ser
         435                 440                 445            
 Gln Pro Ile Lys Phe Pro Ile Asn Gly Leu Ser Asp Val Lys Asn Thr
     450                 455                 460                
 Ser Glu Asp Ser Glu Asn Phe Pro Ser Ser Ser Lys Lys Ser Glu Glu
 465                 470                 475                 480
 Trp Pro Asp Trp Ser Gly Pro Glu Glu Pro Glu Asn Gln Thr Val Asn
                 485                 490                 495    
 Ile Gln Ile Trp Pro Arg Glu Pro Cys Asp Asp Val Lys Ser Gln Cys
             500                 505                 510        
 Thr Thr Leu Asp Val Glu Glu Ser Ser Trp Asp Asp Cys Glu Pro Ser
         515                 520                 525            
 Ser Leu Asp Thr Lys Val Asn Pro Gly Gly Gly Ile Thr Ala Thr Lys
     530                 535                 540                
 Pro Val Thr Ser Gly Glu Gln Lys Pro Ile Pro Ala Leu Leu Ser Leu
 545                 550                 555                 560
 Thr Glu Glu Ser Met Pro Trp Lys Ser Ser Leu Pro Gln Lys Ile Ser
                 565                 570                 575    
 Leu Val Gln Arg Gly Asp Asp Ala Asp Gln Ile Glu Pro Pro Lys Val
             580                 585                 590        
 Ser Ser Gln Glu Arg Pro Leu Lys Val Pro Ser Glu Leu Gly Leu Gly
         595                 600                 605            
 Glu Glu Phe Thr Ile Gln Val Lys Lys Lys Pro Val Lys Asp Pro Glu
     610                 615                 620                
 Met Asp Trp Phe Ala Asp Met Ile Pro Glu Ile Lys Pro Ser Ala Ala
 625                 630                 635                 640
 Phe Leu Ile Leu Pro Glu Leu Arg Thr Glu Met Val Pro Lys Lys Asp
                 645                 650                 655    
 Asp Val Ser Pro Val Met Gln Phe Ser Ser Lys Phe Ala Ala Ala Glu
             660                 665                 670        
 Ile Thr Glu Gly Glu Ala Glu Gly Trp Glu Glu Glu Gly Glu Leu Asn
         675                 680                 685            
 Trp Glu Asp Asn Asn Trp
     690                



      <210> 2467
      <211> 289
      <212> PRT
      <213> Homo sapiens


      <400> 2467
 Ile Ala Gly Val Ala Val Phe Phe Tyr Arg Asp Met Phe Val Arg Lys
   1               5                  10                  15    
 Asp Arg Lys Ile His Lys Asp Ala Glu Ser Ala Gln Ser Cys Thr Asp
              20                  25                  30        
 Ser Ser Gly Ser Phe Ala Lys Leu Asn Gly Leu Phe Asp Ser Pro Val
          35                  40                  45            
 Lys Glu Tyr Gln Gln Asn Ile Asp Ser Pro Lys Leu Ile Val Thr Ser
      50                  55                  60                
 Leu Thr Ser Arg Lys Glu Leu Pro Pro Asn Gly Asp Thr Lys Ser Met
  65                  70                  75                  80
 Val Met Asp His Arg Gly Gln Pro Pro Glu Leu Ala Ala Leu Pro Thr
                  85                  90                  95    
 Pro Glu Ser Thr Pro Val Leu His Gln Lys Thr Leu Gln Ala Met Lys
             100                 105                 110        
 Ser His Ser Glu Lys Ala His Gly His Gly Ala Ser Arg Lys Glu Thr
         115                 120                 125            
 Pro Gln Phe Phe Pro Ser Ser Pro Pro Pro His Ser Pro Leu Ser His
     130                 135                 140                
 Gly His Ile Pro Ser Ala Ile Val Leu Pro Asn Ala Thr His Asp Tyr
 145                 150                 155                 160
 Asn Thr Ser Phe Ser Asn Ser Asn Ala His Lys Ala Glu Lys Lys Leu
                 165                 170                 175    
 Gln Asn Ile Asp His Pro Leu Thr Lys Ser Ser Ser Lys Arg Asp His
             180                 185                 190        
 Arg Arg Ser Val Asp Ser Arg Asn Thr Leu Asn Asp Leu Leu Lys His
         195                 200                 205            
 Leu Asn Asp Pro Asn Ser Asn Pro Lys Ala Ile Met Gly Asp Ile Gln
     210                 215                 220                
 Met Ala His Gln Asn Leu Met Leu Asp Pro Met Gly Ser Met Ser Glu
 225                 230                 235                 240
 Val Pro Pro Lys Val Pro Asn Arg Glu Ala Ser Leu Tyr Ser Pro Pro
                 245                 250                 255    
 Ser Thr Leu Pro Arg Asn Ser Pro Thr Lys Arg Val Asp Val Pro Thr
             260                 265                 270        
 Thr Pro Gly Val Pro Met Thr Ser Leu Glu Arg Gln Arg Gly Tyr His
         275                 280                 285            
 Lys
    



      <210> 2468
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 2468
 Met Gly Ser Val Phe Trp His Val Leu Phe Cys Ile Ser Gly Val Cys
   1               5                  10                  15    
 Leu Trp Cys Ala His Arg Met Ala Ala Phe Leu Gln Gln Met Ala Val
              20                  25                  30        
 Leu Leu Pro Val Asp Cys Glu Arg Pro Ala Ala Val His Trp Leu Ala
          35                  40                  45            
 Leu Cys Gly Cys Cys Tyr Gly Gln Leu Val Trp Glu Ser Arg Thr Arg
      50                  55                  60                
 Ser Cys Phe Trp Ser Leu Glu Cys Leu Cys Phe Gly Gly Gln His Phe
  65                  70                  75                  80
 Gly Ser Val Pro Ser Phe Phe Cys Ser Ser Val Trp Leu
                  85                  90            



      <210> 2469
      <211> 118
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(118)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2469
 Phe Gly Phe Asn Gly Cys Ser Lys Arg Ile Ile Lys Leu Gln Glu Leu
   1               5                  10                  15    
 Ser Asp Leu Glu Glu Arg Glu Asn Glu Asp Ser Met Val Pro Leu Pro
              20                  25                  30        
 Lys Gln Ser Leu Lys Phe Phe Cys Ala Leu Glu Val Val Leu Pro Ser
          35                  40                  45            
 Cys Asp Cys Arg Ser Pro Gly Ile Gly Leu Val Glu Glu Pro Met Asp
      50                  55                  60                
 Lys Val Glu Glu Gly Pro Leu Ser Phe Leu Met Lys Arg Lys Thr Ala
  65                  70                  75                  80
 Gln Lys Leu Ala Ile Gln Lys Ala Leu Ser Asp Ala Phe Gln Lys Leu
                  85                  90                  95    
 Leu Ile Val Val Leu Gly Gln Asp Cys Leu Asp His Pro Xaa Ser Thr
             100                 105                 110        
 Ser Val Ser Val Ser Lys
         115            



      <210> 2470
      <211> 76
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(76)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2470
 Arg Ile Gly Gln Gly Val Pro Val Val His Ser Xaa Val Glu Gly Gly
   1               5                  10                  15    
 Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro
              20                  25                  30        
 Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu
          35                  40                  45            
 Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Xaa Val Lys Val Phe
      50                  55                  60                
 Leu Trp Cys Thr His Lys Trp Lys Glu Asp Pro Met
  65                  70                  75    



      <210> 2471
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 2471
 Met Ala Leu Ala Phe Leu Gly Thr Val Leu Ser Lys Ala Thr Leu Gly
   1               5                  10                  15    
 Ala Arg Leu Thr Thr His Cys Ala His Pro Ala Arg Arg Ala Arg Ala
              20                  25                  30        
 Phe Ser Ser Asp Val Met Thr His Ser Ser Ile Leu Thr Arg Ala Ser
          35                  40                  45            
 Leu Leu Thr Leu Trp Thr Met Phe Thr Arg Arg Thr Lys Ile Leu Thr
      50                  55                  60                
 Glu Gly Ser Gly Val Ser Trp Trp Ala Ala Ala Phe Pro Arg Asp Val
  65                  70                  75                  80
 Val Ala Gly Gly Ser Ile Leu Ala Leu Ala Ser Leu Met Thr Val Val
                  85                  90                  95    
 Thr Ile Gly Ala Leu Leu Thr Ala Val Leu Ala Ala Pro Ala Pro Glu
             100                 105                 110        
 Ala Arg Ser Thr Val Ala Ser Pro Gly Asp Gly Val Ala Gln Ser Pro
         115                 120                 125            
 Ile Phe Ala Leu Ala Pro Ala Gly Ala Val Gly Thr Pro Val Ile Thr
     130                 135                 140                
 Ile Ala Gly
 145        



      <210> 2472
      <211> 437
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(437)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2472
 Val Ser Gln Ala Thr Asp Val Glu Val Gly Thr Asp Leu Val Pro Ser
   1               5                  10                  15    
 Val Thr Val Lys Val Thr Leu Gln Asn Arg Val Ile Leu Gln Lys Ala
              20                  25                  30        
 Lys Leu Ser Val Tyr Val Gln Pro Pro Leu Glu Leu Thr Cys Asp Gln
          35                  40                  45            
 Phe Thr Phe Glu Phe Met Asn Arg Asn Pro Asp Gly Ile Pro Arg Val
      50                  55                  60                
 Ile Gln Cys Lys Phe Arg Leu Pro Leu Lys Leu Ile Cys Leu Pro Gly
  65                  70                  75                  80
 Gln Pro Ser Lys Thr Ala Ser His Lys Ile Thr Ile Asp Thr Asn Lys
                  85                  90                  95    
 Ser Pro Val Ser Leu Leu Ser Leu Phe Pro Gly Phe Ala Ser Gln Ser
             100                 105                 110        
 Asp Asp Asp Gln Val Asn Val Met Gly Phe His Phe Leu Gly Gly Ala
         115                 120                 125            
 Arg Ile Thr Val Leu Ala Ser Lys Thr Ser Ser Thr Asp Ile Arg Ile
     130                 135                 140                
 Pro Gly Val Glu Gln Phe Glu Asp Leu Trp Ala Ser Leu Thr Asn Glu
 145                 150                 155                 160
 Leu Ile Leu Arg Leu Gln Glu Tyr Phe Glu Lys Gln Gly Val Lys Asp
                 165                 170                 175    
 Phe Ala Cys Ser Phe Ser Gly Ser Ile Thr Pro Phe Lys Glu Tyr Phe
             180                 185                 190        
 Glu Leu Ile Gly Ser Ile His Phe Glu Leu Arg Ile Asn Gly Glu Lys
         195                 200                 205            
 Leu Glu Glu Leu Leu Ser Glu Arg Ala Val Gln Phe Arg Ala Ile Gln
     210                 215                 220                
 Arg Arg Leu Leu Ala Arg Phe Lys Asp Lys Thr Pro Ala Pro Leu Gln
 225                 230                 235                 240
 His Leu Gly His Leu Val Arg Met Gly Thr Tyr Lys Gln Val Ile Ala
                 245                 250                 255    
 Leu Ala Asp Ala Val Gly Gly Lys Thr Lys Gly Asn Leu Phe Gln Ser
             260                 265                 270        
 Phe Thr Arg Leu Lys Ser Ala Thr His Leu Val Ile Leu Leu Ile Ala
         275                 280                 285            
 Leu Trp Gln Lys Leu Ser Ala Asp Gln Val Ala Ile Leu Glu Ala Ala
     290                 295                 300                
 Phe Leu Pro Leu Gln Glu Asp Thr Gln Glu Leu Gly Trp Glu Glu Thr
 305                 310                 315                 320
 Val Asp Ala Ala Ile Phe His Leu Xaa Lys Thr Cys Cys Arg Lys Ser
                 325                 330                 335    
 Ala Lys Gln Gln Ala Leu Asn Pro Pro Gly Arg Leu Thr Tyr Pro Asn
             340                 345                 350        
 Asp Thr Ser Gln Leu Lys Lys His Ile Thr Leu Leu Cys Asp Arg Leu
         355                 360                 365            
 Ser Lys Gly Gly Arg Leu Cys Leu Ser Thr Asp Ala Ala Ala Pro His
     370                 375                 380                
 Gln Thr Met Val Met Pro Gly Gly Cys Thr Thr Ile Pro Glu Ser Asp
 385                 390                 395                 400
 Leu Glu Glu Arg Ser Val Glu Gln Asp Ser Thr Glu Leu Phe Thr Asn
                 405                 410                 415    
 His Arg His Leu Thr Ala Glu Thr Pro Arg Pro Glu Val Ser Pro Leu
             420                 425                 430        
 Gln Gly Val Ser Glu
         435        



      <210> 2473
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 2473
 Glu Val Arg Trp Asn Ser Pro Pro Thr Asp Ser Leu Ser Pro Asp Gly
   1               5                  10                  15    
 Gly Ser Ile Glu Leu Glu Phe Tyr Leu Ala Pro Glu Pro Phe Ser Met
              20                  25                  30        
 Pro Ser Leu Leu Gly Ala Pro Pro Tyr Ser Gly Leu Gly Gly Val Gly
          35                  40                  45            
 Asp Pro Tyr Ala Pro Leu Met Val Leu Met Cys Arg Val Cys Leu Glu
      50                  55                  60                
 Asp Lys Pro Ile Lys Pro Leu Pro Cys Cys Lys Lys Ala Val Cys Glu
  65                  70                  75                  80
 Glu Cys Leu Lys Val Tyr Leu Ser Ala Gln Ile Gln Cys Pro Thr Cys
                  85                  90                  95    
 Gln Phe Val Trp Cys Phe Lys Cys His Ser Pro Trp His Glu Gly Val
             100                 105                 110        
 Asn Cys Lys Glu Tyr Lys Lys Gly Asp Lys Leu Leu Arg His Trp Ala
         115                 120                 125            
 Ser Glu Ile Glu His Gly Gln Arg Asn Ala Gln Lys Cys Pro Lys Cys
     130                 135                 140                
 Lys Ile His Ile Gln Arg Thr Glu Gly Cys Asp His Met
 145                 150                 155        



      <210> 2474
      <211> 322
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(322)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2474
 Arg Val Pro Ala Gly Gly Ala Arg Arg Leu Gly Gln Asp Pro Pro Arg
   1               5                  10                  15    
 Leu Pro Pro Gly Val Ala Asp Ala Pro Ala Ala Met Ser Thr Gln Arg
              20                  25                  30        
 Leu Arg Asn Glu Asp Tyr His Asp Tyr Ser Ser Thr Asp Val Ser Pro
          35                  40                  45            
 Glu Glu Ser Pro Ser Glu Gly Leu Asn Asn Leu Ser Ser Pro Gly Ser
      50                  55                  60                
 Tyr Gln Arg Phe Gly Gln Ser Asn Ser Thr Thr Trp Phe Gln Thr Leu
  65                  70                  75                  80
 Ile His Leu Leu Lys Gly Asn Ile Gly Thr Gly Leu Leu Gly Leu Pro
                  85                  90                  95    
 Leu Ala Val Lys Asn Ala Gly Ile Val Met Gly Pro Ile Ser Leu Leu
             100                 105                 110        
 Ile Ile Gly Ile Val Ala Val His Cys Met Gly Ile Leu Val Lys Cys
         115                 120                 125            
 Ala His His Phe Cys Arg Arg Leu Asn Lys Ser Phe Val Asp Tyr Gly
     130                 135                 140                
 Asp Thr Val Met Tyr Gly Leu Glu Ser Ser Pro Cys Ser Trp Leu Arg
 145                 150                 155                 160
 Asn His Ala His Trp Gly Arg Arg Val Val Asp Phe Phe Leu Ile Val
                 165                 170                 175    
 Thr Gln Leu Gly Phe Cys Cys Val Tyr Phe Val Phe Leu Ala Asp Asn
             180                 185                 190        
 Phe Lys Gln Val Ile Glu Ala Ala Asn Gly Thr Thr Asn Asn Cys His
         195                 200                 205            
 Asn Asn Glu Thr Val Ile Leu Thr Pro Thr Met Asp Ser Arg Leu Tyr
     210                 215                 220                
 Met Leu Ser Phe Leu Pro Phe Leu Val Leu Leu Val Phe Ile Arg Asn
 225                 230                 235                 240
 Leu Arg Ala Leu Ser Ile Phe Ser Leu Leu Ala Asn Ile Thr Met Leu
                 245                 250                 255    
 Val Ser Leu Val Met Ile Tyr Gln Phe Ile Val Gln Ile Leu Xaa Met
             260                 265                 270        
 Asp Leu Gln Pro Met Xaa Gln Thr Lys Val Phe His Arg Glu Gln Val
         275                 280                 285            
 Pro Leu Cys Leu Gln His Val Glu Ser Gln Met Glu Gln Phe Trp Ala
     290                 295                 300                
 Glu Cys Phe Ala Gln Arg Val Leu Pro Ile Asn Val Leu Ser Leu Gln
 305                 310                 315                 320
 Lys Lys
        



      <210> 2475
      <211> 322
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(322)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2475
 Arg Val Pro Ala Gly Gly Ala Arg Arg Leu Gly Gln Asp Pro Pro Arg
   1               5                  10                  15    
 Leu Pro Pro Gly Val Ala Asp Ala Pro Ala Ala Met Ser Thr Gln Arg
              20                  25                  30        
 Leu Arg Asn Glu Asp Tyr His Asp Tyr Ser Ser Thr Asp Val Ser Pro
          35                  40                  45            
 Glu Glu Ser Pro Ser Glu Gly Leu Asn Asn Leu Ser Ser Pro Gly Ser
      50                  55                  60                
 Tyr Gln Arg Phe Gly Gln Ser Asn Ser Thr Thr Trp Phe Gln Thr Leu
  65                  70                  75                  80
 Ile His Leu Leu Lys Gly Asn Ile Gly Thr Gly Leu Leu Gly Leu Pro
                  85                  90                  95    
 Leu Ala Val Lys Asn Ala Gly Ile Val Met Gly Pro Ile Ser Leu Leu
             100                 105                 110        
 Ile Ile Gly Ile Val Ala Val His Cys Met Gly Ile Leu Val Lys Cys
         115                 120                 125            
 Ala His His Phe Cys Arg Arg Leu Asn Lys Ser Phe Val Asp Tyr Gly
     130                 135                 140                
 Asp Thr Val Met Tyr Gly Leu Glu Ser Ser Pro Cys Ser Trp Leu Arg
 145                 150                 155                 160
 Asn His Ala His Trp Gly Arg Arg Val Val Asp Phe Phe Leu Ile Val
                 165                 170                 175    
 Thr Gln Leu Gly Phe Cys Cys Val Tyr Phe Val Phe Leu Ala Asp Asn
             180                 185                 190        
 Phe Lys Gln Val Ile Glu Ala Ala Asn Gly Thr Thr Asn Asn Cys His
         195                 200                 205            
 Asn Asn Glu Thr Val Ile Leu Thr Pro Thr Met Asp Ser Arg Leu Tyr
     210                 215                 220                
 Met Leu Ser Phe Leu Pro Phe Leu Val Leu Leu Val Phe Ile Arg Asn
 225                 230                 235                 240
 Leu Arg Ala Leu Ser Ile Phe Ser Leu Leu Ala Asn Ile Thr Met Leu
                 245                 250                 255    
 Val Ser Leu Val Met Ile Tyr Gln Phe Ile Val Gln Ile Leu Xaa Met
             260                 265                 270        
 Asp Leu Gln Pro Met Xaa Gln Thr Lys Val Phe His Arg Glu Gln Val
         275                 280                 285            
 Pro Leu Cys Leu Gln His Val Glu Ser Gln Met Glu Gln Phe Trp Ala
     290                 295                 300                
 Glu Cys Phe Ala Gln Arg Val Leu Pro Ile Asn Val Leu Ser Leu Gln
 305                 310                 315                 320
 Lys Lys
        



      <210> 2476
      <211> 289
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(289)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2476
 Trp Gly Asp Gly Thr Gln Asn Glu Ser His Ser Ser Ser Val Ser Leu
   1               5                  10                  15    
 Thr Ala Phe Leu Ser Asp Thr Lys Asp Arg Gly Pro Pro Val Gln Ser
              20                  25                  30        
 Gln Ile Trp Arg Ser Gly Glu Lys Val Pro Phe Val Gln Thr Tyr Ser
          35                  40                  45            
 Leu Arg Ala Phe Glu Lys Pro Pro Gln Val Gln Thr Gln Ala Leu Arg
      50                  55                  60                
 Asp Phe Glu Lys His Leu Asn Asp Leu Lys Lys Glu Asn Phe Ser Leu
  65                  70                  75                  80
 Lys Leu Leu Ile Tyr Phe Leu Glu Glu Arg Met Gln Gln Lys Tyr Glu
                  85                  90                  95    
 Ala Ser Arg Glu Asp Ile Tyr Lys Arg Asn Thr Glu Leu Lys Val Glu
             100                 105                 110        
 Val Glu Ser Leu Lys Arg Glu Leu Gln Asp Lys Lys Gln His Leu Asp
         115                 120                 125            
 Lys Thr Trp Ala Asp Val Glu Asn Leu Asn Ser Gln Asn Glu Ala Glu
     130                 135                 140                
 Leu Arg Arg Gln Phe Glu Glu Arg Gln Gln Glu Met Glu His Val Tyr
 145                 150                 155                 160
 Glu Leu Leu Glu Asn Lys Met Gln Leu Leu Gln Glu Glu Ser Arg Leu
                 165                 170                 175    
 Ala Lys Asn Glu Ala Ala Arg Met Ala Ala Leu Val Glu Ala Glu Lys
             180                 185                 190        
 Glu Cys Asn Leu Glu Leu Ser Glu Lys Leu Lys Gly Val Thr Lys Asn
         195                 200                 205            
 Trp Glu Asp Val Pro Gly Asp Gln Val Lys Pro Asp Gln Tyr Thr Glu
     210                 215                 220                
 Ala Leu Ala Gln Arg Asp Lys Xaa Val Pro Ser Val Leu Phe Leu Arg
 225                 230                 235                 240
 Leu Ser Phe Ala His Ser Gln Gly Ile Gln Gln Leu Ser Cys Ser Leu
                 245                 250                 255    
 Ser Arg Thr Arg Gln Xaa Glu Leu His Tyr Phe Xaa Asp Phe Met Gly
             260                 265                 270        
 Pro Gln Pro Lys Thr Phe Phe Ser Gly Leu Asn Phe Gln Trp Tyr Pro
         275                 280                 285            
 Leu
    



      <210> 2477
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 2477
 Gln Arg Pro Ser Glu Ala Lys Glu Ile Lys Leu Tyr Ala Gln Ile Pro
   1               5                  10                  15    
 Pro Ile Glu Lys Met Asp Ala Ser Leu Ser Met Leu Ala Asn Cys Glu
              20                  25                  30        
 Lys Leu Ser Leu Ser Thr Asn Cys Ile Glu Lys Ile Ala Asn Leu Asn
          35                  40                  45            
 Gly Leu Glu Ala Val Gly Asp Thr Leu Glu Glu Leu Trp Ile Ser Tyr
      50                  55                  60                
 Asn Phe Ile Glu Lys Leu Lys Gly Ile His Ile Met Lys Lys Leu Lys
  65                  70                  75                  80
 Ile Leu Tyr Met Ser Asn Asn Leu Val Lys Asp Trp Gly Thr Pro Val
                  85                  90                  95    
 Ile Lys Gly Asp Glu Glu Glu Asp Asn
             100                 105



      <210> 2478
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 2478
 Cys Lys Asn Thr Leu Ile Arg Gln Asn Ile Pro Arg Ala Gln Phe Pro
   1               5                  10                  15    
 Ala Thr Ser Pro Arg Ser Ile Ile Gln Gln Pro Asn Pro Phe Pro Arg
              20                  25                  30        
 Arg Phe Val Leu Pro Leu Asn Val Ser Leu Asn Ala Pro Glu Gly Asp
          35                  40                  45            
 Asn Leu Ser Pro Leu Ser Tyr Thr Ser Ala Ser Ala Val Lys Gln Ala
      50                  55                  60                
 Asp Gly Thr Ile Trp Cys Ser His Glu Asn Leu His Gln Glu Asp Leu
  65                  70                  75                  80
 Glu Lys Glu Gly Gly Ile Glu Phe Pro Gln Ile Tyr Tyr Asp Arg Phe
                  85                  90                  95    
 Ser Gly Lys Lys Tyr His Phe Phe Tyr Gly Cys Gly Phe Arg His Leu
             100                 105                 110        
 Val Gly Asp Ser Leu Ile Lys Val Asp Val Val Asn Lys Thr Leu Lys
         115                 120                 125            
 Val Trp Arg Glu Asp Gly Phe Tyr Pro Ser Glu Pro Val Phe Val Pro
     130                 135                 140                
 Ala Pro Gly Thr Asn Glu Glu Asp Gly Gly Val Ile Leu Ser Val Val
 145                 150                 155                 160
 Ile Thr Pro Asn Gln Asn Glu Ser Asn Phe Leu Leu Val Leu Asp Ala
                 165                 170                 175    
 Lys Asn Phe Glu Glu Leu Gly Arg Ala Glu Val Pro Val Gln Met Pro
             180                 185                 190        
 Tyr Gly Phe His Gly Thr Phe Ile Pro Ile
         195                 200        



      <210> 2479
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 2479
 Cys Lys Asn Thr Leu Ile Arg Gln Asn Ile Pro Arg Ala Gln Phe Pro
   1               5                  10                  15    
 Ala Thr Ser Pro Arg Ser Ile Ile Gln Gln Pro Asn Pro Phe Pro Arg
              20                  25                  30        
 Arg Phe Val Leu Pro Leu Asn Val Ser Leu Asn Ala Pro Glu Gly Asp
          35                  40                  45            
 Asn Leu Ser Pro Leu Ser Tyr Thr Ser Ala Ser Ala Val Lys Gln Ala
      50                  55                  60                
 Asp Gly Thr Ile Trp Cys Ser His Glu Asn Leu His Gln Glu Asp Leu
  65                  70                  75                  80
 Glu Lys Glu Gly Gly Ile Glu Phe Pro Gln Ile Tyr Tyr Asp Arg Phe
                  85                  90                  95    
 Ser Gly Lys Lys Tyr His Phe Phe Tyr Gly Cys Gly Phe Arg His Leu
             100                 105                 110        
 Val Gly Asp Ser Leu Ile Lys Val Asp Val Val Asn Lys Thr Leu Lys
         115                 120                 125            
 Val Trp Arg Glu Asp Gly Phe Tyr Pro Ser Glu Pro Val Phe Val Pro
     130                 135                 140                
 Ala Pro Gly Thr Asn Glu Glu Asp Gly Gly Val Ile Leu Ser Val Val
 145                 150                 155                 160
 Ile Thr Pro Asn Gln Asn Glu Ser Asn Phe Leu Leu Val Leu Asp Ala
                 165                 170                 175    
 Lys Asn Phe Glu Glu Leu Gly Arg Ala Glu Val Pro Val Gln Met Pro
             180                 185                 190        
 Tyr Gly Phe His Gly Thr Phe Ile Pro Ile
         195                 200        



      <210> 2480
      <211> 160
      <212> PRT
      <213> Homo sapiens


      <400> 2480
 Leu Ser Leu Thr Lys Asn Cys Ala Leu Leu Gly Glu Glu Thr Met Met
   1               5                  10                  15    
 Glu Gln Glu Met Thr Arg Leu His Arg Arg Val Ser Glu Val Glu Ala
              20                  25                  30        
 Val Leu Ser Gln Lys Glu Val Glu Leu Lys Ala Ser Glu Thr Gln Arg
          35                  40                  45            
 Ser Pro Leu Glu Gln Asp Leu Ala Thr Tyr Ile Thr Glu Cys Ser Ser
      50                  55                  60                
 Leu Lys Arg Ser Leu Glu Gln Ala Arg Met Glu Val Ser Gln Glu Asp
  65                  70                  75                  80
 Asp Lys Ala Leu Gln Leu Leu His Asp Ile Arg Glu Gln Ser Arg Lys
                  85                  90                  95    
 Leu Gln Glu Ile Lys Glu Gln Glu Tyr Gln Ala Gln Val Glu Glu Met
             100                 105                 110        
 Arg Leu Met Met Asn Gln Leu Glu Glu Asp Leu Val Ser Ala Arg Arg
         115                 120                 125            
 Arg Ser Asp Leu Tyr Glu Ser Glu Leu Arg Glu Ser Arg Leu Ala Ala
     130                 135                 140                
 Glu Glu Phe Lys Arg Lys Ala Thr Glu Cys Gln His Lys Leu Leu Lys
 145                 150                 155                 160





      <210> 2481
      <211> 675
      <212> PRT
      <213> Homo sapiens


      <400> 2481
 Met Ala Trp Ala Gly Arg Gly Arg Gly Ser Arg Gln Gly Ser Glu Leu
   1               5                  10                  15    
 His Leu Pro Trp Ala Ile Asp Val Cys Leu Phe Ser Leu Val Arg Ser
              20                  25                  30        
 Gly Phe Arg Phe Leu Arg Glu Val Trp Trp Glu Ile Trp Lys Lys Val
          35                  40                  45            
 Leu Leu Leu Leu His Val Ala Asn Gly Ala Gln Gln Ala Gly Pro Ile
      50                  55                  60                
 Pro Trp Asn Thr Gly Leu Gln Ala Asn His Ser Val Pro Val Ser Lys
  65                  70                  75                  80
 Pro His Gln Lys Trp Pro Val Gln His Phe Gln Glu Leu Leu Arg Ser
                  85                  90                  95    
 Ala Asn Ser Leu Thr Ala Pro Phe Lys Gln Val Gln Tyr Trp Arg Gly
             100                 105                 110        
 Thr Lys Met Asn Gln Arg Val Pro Val Pro Gln Ile His Ser Trp Phe
         115                 120                 125            
 Arg Met Phe Cys Gly Met Ala His Glu Ser His Gly Ile Gly Lys Trp
     130                 135                 140                
 Gly Val Ala Leu Glu Gly His Pro Pro Gly Pro Gly Lys Gln Glu Ser
 145                 150                 155                 160
 Ile Ala Asn Ala Cys Trp Glu Ala Ala Val Arg Ser Pro Gly Ser Arg
                 165                 170                 175    
 Ser His Lys Ala Glu Thr Lys Ser Ser Lys Ser Arg Asp Gln Ile Leu
             180                 185                 190        
 Ser Val Leu Arg Pro Ala Ser Phe Val Arg Asp Lys Ser Ile Pro Gln
         195                 200                 205            
 Pro Trp Leu Glu Ser Asp Gly Ile Asn Lys Arg Trp Ser Pro Thr Cys
     210                 215                 220                
 Leu Ser Gly Glu Pro Ser Leu Gly Arg Val Asn Pro Leu Leu His Glu
 225                 230                 235                 240
 Leu Gln Thr Gln Cys Phe Val Arg Thr Pro Ser Tyr Gln Arg Ala Thr
                 245                 250                 255    
 Glu Ala Ala Lys Pro Gln Glu Arg Cys Thr Ile Gln Leu Asn Lys Met
             260                 265                 270        
 Cys Cys Leu Gln Ala Gly Ser Phe Ser Arg Tyr Ala Ser Val Ile Ala
         275                 280                 285            
 Ile Lys His Ile Cys His Ala His Ser Thr Pro Lys Ala Leu Leu Thr
     290                 295                 300                
 Ser Phe Leu Val Leu Thr Thr Thr Arg Ser Leu Asn Leu His Leu His
 305                 310                 315                 320
 Leu Arg Leu Ser His Pro Asp Lys Phe Arg Asp Gly Gly Val Ser Ser
                 325                 330                 335    
 Ser Gln Tyr Ser Arg Tyr Cys Ser Leu Thr Gln Pro Asp Phe Asp Ser
             340                 345                 350        
 Ser Asn Ser Ser Thr Phe Phe Leu Leu Leu Thr Ile Ser Leu Leu Ser
         355                 360                 365            
 Ser Gln Phe Cys Ile Arg Leu Ile Ser Leu Pro Glu Cys Pro Val Ser
     370                 375                 380                
 Gln Trp Gln Glu Ala Ala Arg Glu His Leu Gly Gly Gly Ser Asp Leu
 385                 390                 395                 400
 Ser Ser Met Gly Glu Thr His Pro Asp Leu Gly Gly Gly Pro Ser Glu
                 405                 410                 415    
 Gly Pro Gly Gly Trp Pro Trp Glu Gln Val Ser Ala Ala Phe Ala Gln
             420                 425                 430        
 Leu Val Leu Val Ser Thr Met Ser Phe Gln Gly Thr Trp Arg Lys Arg
         435                 440                 445            
 Phe Ser Ser Thr Asp Thr Gln Ile Leu Pro Phe Thr Cys Ala Tyr Gly
     450                 455                 460                
 Leu Val Leu Gln Val Pro Met Met His Gln Thr Thr Glu Val Asn Tyr
 465                 470                 475                 480
 Gly Gln Phe Gln Asp Thr Ala Gly His Gln Val Gly Val Leu Glu Leu
                 485                 490                 495    
 Pro Tyr Leu Gly Ser Ala Val Ser Leu Phe Leu Val Leu Pro Arg Asp
             500                 505                 510        
 Lys Asp Thr Pro Leu Ser His Ile Glu Pro His Leu Thr Ala Ser Thr
         515                 520                 525            
 Ile His Leu Trp Thr Thr Ser Leu Arg Arg Ala Arg Met Asp Val Phe
     530                 535                 540                
 Leu Pro Ser Glu Leu Thr Lys Glu Pro Phe Arg Trp Asp Gln Arg Leu
 545                 550                 555                 560
 Phe Ala Leu Val Leu Arg Leu Pro Gly Thr Met Ser Val Glu Ser Glu
                 565                 570                 575    
 Gln Leu Thr Gly Val Pro Leu Asp Asp Ser Ala Ile Thr Pro Met Cys
             580                 585                 590        
 Glu Val Thr Gly Val Gly Met Glu Cys Phe Ser Asp Ala Lys Asp Thr
         595                 600                 605            
 Ile Glu Asp Leu Ser Glu Met His Gly Ser Gln Asp Leu Ser Glu Met
     610                 615                 620                
 Arg Gly Asn Pro Thr Lys Pro Ser Pro Pro Leu Ser Gly Thr Thr Val
 625                 630                 635                 640
 Glu Asn Phe Gly Ser Arg Gly Thr Asp Ser Tyr Glu Ala Phe Ser Glu
                 645                 650                 655    
 Pro Ser Leu Gly Lys Glu Pro Val Thr His Arg Thr Arg Val Pro Leu
             660                 665                 670        
 Gln Trp Pro
         675



      <210> 2482
      <211> 247
      <212> PRT
      <213> Homo sapiens


      <400> 2482
 Leu Pro Pro Arg Gly Pro Ala Thr Phe Gly Ser Pro Gly Cys Pro Pro
   1               5                  10                  15    
 Ala Asn Ser Pro Pro Ser Ala Pro Ala Thr Pro Glu Pro Ala Arg Ala
              20                  25                  30        
 Pro Glu Arg Val Met Ala Asn Ala Gly Leu Gln Leu Leu Gly Phe Ile
          35                  40                  45            
 Leu Ala Phe Leu Gly Trp Ile Gly Ala Ile Val Ser Thr Ala Leu Pro
      50                  55                  60                
 Gln Trp Arg Ile Tyr Ser Tyr Ala Gly Asp Asn Ile Val Thr Ala Gln
  65                  70                  75                  80
 Ala Met Tyr Glu Gly Leu Trp Met Ser Cys Val Ser Gln Ser Thr Gly
                  85                  90                  95    
 Gln Ile Gln Cys Lys Val Phe Asp Ser Leu Leu Asn Leu Ser Ser Thr
             100                 105                 110        
 Leu Gln Ala Thr Leu Ala Leu Met Val Val Gly Ile Leu Leu Gly Val
         115                 120                 125            
 Ile Ala Ile Phe Val Ala Thr Val Gly Met Lys Cys Met Lys Cys Leu
     130                 135                 140                
 Glu Asp Asp Glu Val Gln Lys Met Arg Met Ala Val Ile Gly Gly Ala
 145                 150                 155                 160
 Ile Phe Leu Leu Ala Gly Leu Ala Ile Leu Val Ala Thr Ala Trp Tyr
                 165                 170                 175    
 Gly Asn Arg Ile Val Gln Glu Phe Tyr Asp Pro Met Thr Pro Val Asn
             180                 185                 190        
 Ala Arg Tyr Glu Phe Gly Gln Ala Leu Phe Thr Gly Trp Ala Ala Ala
         195                 200                 205            
 Ser Leu Cys Leu Leu Gly Gly Ala Leu Leu Cys Cys Ser Cys Pro Arg
     210                 215                 220                
 Lys Thr Thr Ser Tyr Pro Thr Pro Arg Pro Tyr Pro Lys Pro Ala Pro
 225                 230                 235                 240
 Ser Ser Gly Lys Asp Tyr Val
                 245        



      <210> 2483
      <211> 313
      <212> PRT
      <213> Homo sapiens


      <400> 2483
 Arg Ile Ile Ser Thr Ile Thr Tyr Gln Phe Ser Ala Ala Leu Gly Gln
   1               5                  10                  15    
 Glu Val Phe Tyr Ile Thr Phe Leu Pro Phe Thr His Trp Asn Ile Asp
              20                  25                  30        
 Pro Tyr Leu Ser Arg Arg Leu Ile Ile Ile Trp Val Leu Val Met Tyr
          35                  40                  45            
 Ile Gly Gln Val Ala Lys Asp Val Leu Lys Trp Pro Arg Pro Ser Ser
      50                  55                  60                
 Pro Pro Val Val Lys Leu Glu Lys Arg Leu Ile Ala Glu Tyr Gly Met
  65                  70                  75                  80
 Pro Ser Thr His Ala Met Ala Ala Thr Ala Ile Ala Phe Thr Leu Leu
                  85                  90                  95    
 Ile Ser Thr Met Asp Arg Tyr Gln Tyr Pro Phe Val Leu Gly Leu Val
             100                 105                 110        
 Met Ala Val Val Phe Ser Thr Leu Val Cys Leu Ser Arg Leu Tyr Thr
         115                 120                 125            
 Gly Met His Thr Val Leu Asp Val Leu Gly Gly Val Leu Ile Thr Ala
     130                 135                 140                
 Leu Leu Ile Val Leu Thr Tyr Pro Ala Trp Thr Phe Ile Asp Cys Leu
 145                 150                 155                 160
 Asp Ser Ala Ser Pro Leu Phe Pro Val Cys Val Ile Val Val Pro Phe
                 165                 170                 175    
 Phe Leu Cys Tyr Asn Tyr Pro Val Ser Asp Tyr Tyr Ser Pro Thr Arg
             180                 185                 190        
 Ala Asp Thr Thr Thr Ile Leu Ala Ala Gly Ala Gly Val Thr Ile Gly
         195                 200                 205            
 Phe Trp Ile Asn His Phe Phe Gln Leu Val Ser Lys Pro Ala Glu Ser
     210                 215                 220                
 Leu Pro Val Ile Gln Asn Ile Pro Pro Leu Thr Thr Tyr Met Leu Val
 225                 230                 235                 240
 Leu Gly Leu Thr Lys Phe Ala Val Gly Ile Val Leu Ile Leu Leu Val
                 245                 250                 255    
 Arg Gln Leu Val Gln Asn Leu Ser Leu Gln Val Leu Tyr Ser Trp Phe
             260                 265                 270        
 Lys Val Val Thr Arg Asn Lys Glu Ala Arg Arg Arg Leu Glu Ile Glu
         275                 280                 285            
 Val Pro Tyr Lys Phe Val Thr Tyr Thr Ser Val Gly Ile Gly Thr Lys
     290                 295                 300                
 Val Val Ala Gln Met Pro Thr Asp Val
 305                 310            



      <210> 2484
      <211> 44
      <212> PRT
      <213> Homo sapiens


      <400> 2484
 Ser His Ile Cys Leu Lys Lys Ser Ala Lys Ser Leu Thr Gly Thr Trp
   1               5                  10                  15    
 Met Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Thr Gln Glu Gln Lys
              20                  25                  30        
 Thr Lys His Cys Met Phe Ser Leu Ile Ser Gly Ser
          35                  40                



      <210> 2485
      <211> 44
      <212> PRT
      <213> Homo sapiens


      <400> 2485
 Ser His Ile Cys Leu Lys Lys Ser Ala Lys Ser Leu Thr Gly Thr Trp
   1               5                  10                  15    
 Met Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Thr Gln Glu Gln Lys
              20                  25                  30        
 Thr Lys His Cys Met Phe Ser Leu Ile Ser Gly Ser
          35                  40                



      <210> 2486
      <211> 47
      <212> PRT
      <213> Homo sapiens


      <400> 2486
 Pro Arg Gln Glu Lys Lys Ser Ser His Val Ser Thr Arg Arg Ser Pro
   1               5                  10                  15    
 Lys Leu Leu Arg Glu Lys Pro Glu Ala Ala Ala Gly Glu Ala Ala Ala
              20                  25                  30        
 Glu Ala Gly Leu Pro Met Phe Ala Arg Ser Arg Ala Arg Ser Arg
          35                  40                  45        



      <210> 2487
      <211> 414
      <212> PRT
      <213> Homo sapiens


      <400> 2487
 Trp Pro Cys Gly Ala Ala Pro Gly Leu Thr His Ala Ser Glu Arg Met
   1               5                  10                  15    
 Phe Thr Leu Thr Thr Met Ile Gln Ala Leu Ala Pro Val Met Gly Trp
              20                  25                  30        
 Asp Arg Lys Pro Leu Lys Met Phe Ser Ser Glu Glu Met Arg Gly His
          35                  40                  45            
 Leu His His His His Lys Cys Leu Thr Lys Ile Leu Lys Val Glu Gly
      50                  55                  60                
 Gln Val Pro Asp Leu Pro Ser Cys Leu Pro Leu Thr Asp Asn Thr Arg
  65                  70                  75                  80
 Met Leu Ala Ser Ile Leu Ile Asn Met Leu Tyr Asp Asp Leu Arg Cys
                  85                  90                  95    
 Asp Pro Glu Arg Asp His Phe Arg Lys Ile Cys Glu Glu Tyr Ile Thr
             100                 105                 110        
 Gly Lys Phe Asp Pro Gln Asp Met Asp Lys Asn Leu Asn Ala Ile Gln
         115                 120                 125            
 Thr Val Ser Gly Ile Leu Gln Gly Pro Phe Asp Leu Gly Asn Gln Leu
     130                 135                 140                
 Leu Gly Leu Lys Gly Val Met Glu Met Met Val Ala Leu Cys Gly Ser
 145                 150                 155                 160
 Glu Arg Glu Thr Asp Gln Leu Val Ala Val Glu Ala Leu Ile His Ala
                 165                 170                 175    
 Ser Thr Lys Leu Ser Arg Ala Thr Phe Ile Ile Thr Asn Gly Val Ser
             180                 185                 190        
 Leu Leu Lys Gln Ile Tyr Lys Thr Thr Lys Asn Glu Lys Ile Lys Ile
         195                 200                 205            
 Arg Thr Leu Val Gly Leu Cys Lys Leu Gly Ser Ala Gly Gly Thr Asp
     210                 215                 220                
 Tyr Gly Leu Arg Gln Phe Ala Glu Gly Ser Thr Glu Lys Leu Ala Lys
 225                 230                 235                 240
 Gln Cys Arg Lys Trp Leu Cys Asn Met Ser Ile Asp Thr Arg Thr Arg
                 245                 250                 255    
 Arg Trp Ala Val Glu Gly Leu Ala Tyr Leu Thr Leu Asp Ala Asp Val
             260                 265                 270        
 Lys Asp Asp Phe Val Gln Asp Val Pro Ala Leu Gln Ala Met Phe Glu
         275                 280                 285            
 Leu Ala Lys Thr Ser Asp Lys Thr Ile Leu Tyr Ser Val Ala Thr Thr
     290                 295                 300                
 Leu Val Asn Cys Thr Asn Ser Tyr Asp Val Lys Glu Val Ile Pro Glu
 305                 310                 315                 320
 Leu Val Gln Leu Ala Lys Phe Ser Lys Gln His Val Pro Glu Glu His
                 325                 330                 335    
 Pro Lys Asp Lys Lys Asp Phe Ile Asp Met Arg Val Lys Arg Leu Leu
             340                 345                 350        
 Lys Ala Gly Val Ile Ser Ala Leu Ala Cys Met Val Lys Ala Asp Ser
         355                 360                 365            
 Ala Ile Leu Thr Asp Gln Thr Lys Glu Leu Leu Ala Arg Val Phe Leu
     370                 375                 380                
 Ala Leu Cys Asp Asn Pro Lys Asp Arg Gly Thr Ile Val Ala Gln Gly
 385                 390                 395                 400
 Gly Gly Lys Ala Leu Ile Pro Leu Ala Leu Glu Gly Thr Asp
                 405                 410                



      <210> 2488
      <211> 742
      <212> PRT
      <213> Homo sapiens


      <400> 2488
 Met Asp Ser Leu Lys Gln Glu Thr Gln Gly Leu Gln Lys Glu Lys Glu
   1               5                  10                  15    
 Ser Arg Glu Lys Glu Leu Met Gly Phe Ser Lys Ser Val Asn Glu Ala
              20                  25                  30        
 Arg Ser Lys Met Asp Val Ala Gln Ser Glu Leu Asp Ile Tyr Leu Ser
          35                  40                  45            
 Arg His Asn Thr Ala Val Ser Gln Leu Thr Lys Ala Lys Glu Ala Leu
      50                  55                  60                
 Ile Ala Ala Ser Glu Thr Leu Lys Glu Arg Lys Ala Ala Ile Arg Asp
  65                  70                  75                  80
 Ile Glu Gly Lys Leu Pro Gln Thr Glu Gln Glu Leu Lys Glu Lys Glu
                  85                  90                  95    
 Lys Glu Leu Gln Lys Leu Thr Gln Glu Glu Thr Asn Phe Lys Ser Leu
             100                 105                 110        
 Asp Lys Met Ala Val Trp Ala Lys Lys Met Thr Glu Ile Gln Thr Pro
         115                 120                 125            
 Glu Asn Thr Pro Arg Leu Phe Asp Leu Val Lys Val Lys Asp Glu Lys
     130                 135                 140                
 Ile Arg Gln Ala Phe Tyr Phe Ala Leu Arg Asp Thr Leu Val Ala Asp
 145                 150                 155                 160
 Asn Leu Asp Gln Ala Thr Arg Val Ala Tyr Gln Lys Asp Arg Arg Trp
                 165                 170                 175    
 Arg Val Val Thr Leu Gln Gly Gln Ile Ile Glu Gln Ser Gly Thr Met
             180                 185                 190        
 Thr Gly Gly Gly Ser Lys Val Met Lys Gly Arg Met Gly Ser Ser Leu
         195                 200                 205            
 Val Ile Glu Ile Ser Glu Glu Glu Val Asn Lys Met Glu Ser Gln Leu
     210                 215                 220                
 Gln Asn Asp Ser Lys Lys Ala Met Gln Ile Gln Glu Gln Lys Val Gln
 225                 230                 235                 240
 Leu Glu Glu Arg Val Val Lys Leu Arg His Ser Glu Arg Glu Met Arg
                 245                 250                 255    
 Asn Thr Leu Glu Lys Phe Thr Ala Ser Ile Gln Arg Leu Ile Glu Gln
             260                 265                 270        
 Glu Glu Tyr Leu Asn Val Gln Val Lys Glu Leu Glu Ala Asn Val Leu
         275                 280                 285            
 Ala Thr Ala Pro Asp Lys Lys Lys Gln Lys Leu Leu Glu Glu Asn Val
     290                 295                 300                
 Ser Ala Phe Lys Thr Glu Tyr Asp Ala Val Ala Glu Lys Ala Glu Glu
 305                 310                 315                 320
 Ser Leu Pro Glu Ile Gln Lys Glu His Arg Asn Leu Leu Gln Glu Leu
                 325                 330                 335    
 Lys Val Ile Gln Glu Asn Glu His Ala Leu Gln Lys Asp Ala Leu Ser
             340                 345                 350        
 Ile Lys Leu Lys Leu Glu Gln Ile Asp Gly His Ile Ala Glu His Asn
         355                 360                 365            
 Ser Lys Ile Lys Tyr Trp His Lys Glu Ile Ser Lys Ile Ser Leu His
     370                 375                 380                
 Pro Ile Glu Asp Asn Pro Ile Glu Glu Ile Ser Val Leu Ser Pro Glu
 385                 390                 395                 400
 Asp Leu Glu Ala Ile Lys Asn Pro Asp Ser Ile Thr Asn Gln Ile Ala
                 405                 410                 415    
 Leu Leu Glu Ala Arg Cys His Glu Met Lys Pro Asn Leu Gly Ala Ile
             420                 425                 430        
 Ala Glu Tyr Lys Lys Lys Glu Glu Leu Tyr Leu Gln Arg Val Ala Glu
         435                 440                 445            
 Leu Asp Lys Ile Thr Tyr Glu Arg Asp Ser Phe Arg Gln Ala Tyr Glu
     450                 455                 460                
 Asp Leu Arg Lys Gln Arg Leu Asn Glu Phe Met Gly Ser Val Arg Pro
 465                 470                 475                 480
 Pro Lys Lys Ser Trp Lys Lys Ile Phe Asn Leu Ser Gly Gly Glu Lys
                 485                 490                 495    
 Thr Leu Ser Ser Leu Ala Leu Val Phe Ala Leu His His Tyr Lys Pro
             500                 505                 510        
 Thr Pro Leu Tyr Phe Met Asp Glu Ile Asp Ala Ala Leu Asp Phe Lys
         515                 520                 525            
 Asn Val Ser Ile Val Ala Phe Tyr Ile Tyr Glu Ala Val Trp Phe Leu
     530                 535                 540                
 Ser Asn Ile Thr Ala Gly Asn Gln Gln Gln Val Gln Ala Val Ile Asp
 545                 550                 555                 560
 Ala Asn Leu Val Pro Met Ile Ile His Leu Leu Asp Lys Gly Asp Phe
                 565                 570                 575    
 Gly Thr Gln Lys Glu Ala Ala Trp Ala Ile Ser Asn Leu Thr Ile Ser
             580                 585                 590        
 Gly Arg Lys Asp Gln Val Ala Tyr Leu Ile Gln Gln Asn Val Ile Pro
         595                 600                 605            
 Pro Phe Cys Asn Leu Leu Thr Val Lys Asp Ala Gln Val Val Gln Val
     610                 615                 620                
 Val Leu Asp Gly Leu Ser Asn Ile Leu Lys Met Ala Glu Asp Glu Ala
 625                 630                 635                 640
 Glu Thr Ile Gly Asn Leu Ile Glu Glu Cys Gly Gly Leu Glu Lys Ile
                 645                 650                 655    
 Glu Gln Leu Gln Asn His Glu Asn Glu Asp Ile Tyr Lys Leu Ala Tyr
             660                 665                 670        
 Glu Ile Ile Asp Gln Phe Phe Ser Ser Asp Asp Val Phe Asn Asn Phe
         675                 680                 685            
 Val Val Phe Leu Ile Leu Tyr Ile Asn Ile Asp Leu Asp Lys Val Ile
     690                 695                 700                
 Tyr Ile Gly Ser Ser Leu Met Lys Gln Thr Pro Ser Pro Gly Val Thr
 705                 710                 715                 720
 Val Tyr Glu Ser Val Val Val Val Leu Tyr Val Asn Ala Cys Lys Leu
                 725                 730                 735    
 Asp Ser Pro Ser Gly Gly
             740        



      <210> 2489
      <211> 248
      <212> PRT
      <213> Homo sapiens


      <400> 2489
 Met Arg Leu Gln Arg Pro Arg Gln Ala Pro Ala Gly Gly Arg Arg Ala
   1               5                  10                  15    
 Pro Arg Gly Gly Arg Gly Ser Pro Tyr Arg Pro Asp Pro Gly Arg Gly
              20                  25                  30        
 Ala Arg Arg Leu Arg Arg Phe Gln Lys Gly Gly Glu Gly Ala Pro Arg
          35                  40                  45            
 Ala Asp Pro Pro Trp Ala Pro Leu Gly Thr Met Ala Leu Leu Ala Leu
      50                  55                  60                
 Leu Leu Val Val Ala Leu Pro Arg Val Trp Thr Asp Ala Asn Leu Thr
  65                  70                  75                  80
 Ala Arg Gln Arg Asp Pro Glu Asp Ser Gln Arg Thr Asp Glu Gly Asp
                  85                  90                  95    
 Asn Arg Val Trp Cys His Val Cys Glu Arg Glu Asn Thr Phe Glu Cys
             100                 105                 110        
 Gln Asn Pro Arg Arg Cys Lys Trp Thr Glu Pro Tyr Cys Val Ile Ala
         115                 120                 125            
 Ala Val Lys Ile Phe Pro Arg Phe Phe Met Val Ala Lys Gln Cys Ser
     130                 135                 140                
 Ala Gly Cys Ala Ala Met Glu Arg Pro Lys Pro Glu Glu Lys Arg Phe
 145                 150                 155                 160
 Leu Leu Glu Glu Pro Met Pro Phe Phe Tyr Leu Lys Cys Cys Lys Ile
                 165                 170                 175    
 Arg Tyr Cys Asn Leu Gly Gly Ala Asn Leu Ser Thr His Gln Cys Ser
             180                 185                 190        
 Lys Asn Met Leu Gly Ala Trp Val Arg Ala Val Val Gly Cys Gly Trp
         195                 200                 205            
 Pro Ser Ser Cys Cys Trp Pro Pro Leu Gln Pro Ala Ser Ala Cys Leu
     210                 215                 220                
 Glu Pro Arg Asp Cys His Arg Leu Ser Leu Pro Glu His Gly Leu Ala
 225                 230                 235                 240
 Pro Asp Arg Cys His Leu Leu His
                 245            



      <210> 2490
      <211> 391
      <212> PRT
      <213> Homo sapiens


      <400> 2490
 Gly Phe Val Glu Ala Gly Glu Glu Cys Tyr Cys Val Ser Gly Gln Glu
   1               5                  10                  15    
 Cys Arg Asp Leu Cys Cys Phe Ala His Asn Cys Ser Leu Arg Pro Gly
              20                  25                  30        
 Ala Gln Cys Ala His Gly Asp Cys Cys Val Arg Cys Leu Leu Lys Pro
          35                  40                  45            
 Ala Gly Ala Leu Cys Arg Gln Ala Met Gly Asp Cys Asp Leu Pro Glu
      50                  55                  60                
 Phe Cys Thr Gly Thr Ser Ser His Cys Pro Pro Asp Val Tyr Leu Leu
  65                  70                  75                  80
 Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly Tyr Cys Trp Asp Gly Ala
                  85                  90                  95    
 Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln Leu Trp Gly Pro Gly Ser
             100                 105                 110        
 His Pro Ala Pro Glu Ala Cys Phe Gln Val Val Asn Ser Ala Gly Asp
         115                 120                 125            
 Ala His Gly Asn Cys Gly Gln Asp Ser Glu Gly His Phe Leu Pro Cys
     130                 135                 140                
 Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu Gln Cys Gln Gly Gly Lys
 145                 150                 155                 160
 Pro Ser Leu Leu Ala Pro His Met Val Pro Val Asp Ser Thr Val His
                 165                 170                 175    
 Leu Asp Gly Gln Glu Val Thr Cys Arg Gly Ala Leu Ala Leu Pro Ser
             180                 185                 190        
 Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu Val Glu Pro Gly Thr Gln
         195                 200                 205            
 Cys Gly Pro Arg Met Val Cys Gln Ser Arg Arg Cys Arg Lys Asn Ala
     210                 215                 220                
 Phe Gln Glu Leu Gln Arg Cys Leu Thr Ala Cys His Ser His Gly Val
 225                 230                 235                 240
 Cys Asn Ser Asn His Asn Cys His Cys Ala Pro Gly Trp Ala Pro Pro
                 245                 250                 255    
 Phe Cys Asp Lys Pro Gly Phe Gly Gly Ser Met Asp Ser Gly Pro Val
             260                 265                 270        
 Gln Ala Glu Asn His Asp Thr Phe Leu Leu Ala Met Leu Leu Ser Val
         275                 280                 285            
 Leu Leu Pro Leu Leu Pro Gly Ala Gly Leu Ala Trp Cys Cys Tyr Arg
     290                 295                 300                
 Leu Pro Gly Ala His Leu Gln Arg Cys Ser Trp Gly Cys Arg Arg Asp
 305                 310                 315                 320
 Pro Ala Cys Ser Gly Pro Lys Asp Gly Pro His Arg Asp His Pro Leu
                 325                 330                 335    
 Gly Gly Val His Pro Met Glu Leu Gly Pro Thr Ala Thr Gly Gln Pro
             340                 345                 350        
 Trp Pro Leu Asp Pro Glu Asn Ser His Glu Pro Ser Ser His Pro Glu
         355                 360                 365            
 Lys Pro Leu Pro Ala Val Ser Pro Asp Pro Gln Ala Asp Gln Val Gln
     370                 375                 380                
 Met Pro Arg Ser Cys Leu Trp
 385                 390    



      <210> 2491
      <211> 203
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(203)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2491
 Ala Ala Ala Arg Thr Phe Trp Tyr Lys Leu Phe Pro Cys Arg Gly Ser
   1               5                  10                  15    
 Gly Gly Ala Ala Lys Ala Ala Glu Gln Lys Arg Gln Val Gly Gly Arg
              20                  25                  30        
 Ala Glu Pro Gly Thr Ala Ala Pro Cys Gly Ala Arg Cys Pro Gly Pro
          35                  40                  45            
 Thr Pro Gly Trp Gln Val Pro Ala Thr Lys Ala Leu Leu Ser Gln Pro
      50                  55                  60                
 Met Gly Cys Pro Pro Pro Gly Pro Cys Arg Gly His Thr Xaa Ala Asp
  65                  70                  75                  80
 Pro Gln Leu Pro Leu Thr His Ala Pro Pro Glu Ala Arg Leu Ser Pro
                  85                  90                  95    
 Gln Gln Pro Pro Pro Ser Pro Pro Gly Ser Ala Thr Pro Gly Ala Xaa
             100                 105                 110        
 Ala Gly Val Ala Ser Pro Lys Pro Thr Leu Pro Ala Pro Gly Ala Pro
         115                 120                 125            
 Gly Thr Pro Gln Arg Leu Pro Gly Pro Arg Arg Glu Lys Pro Ala Phe
     130                 135                 140                
 Leu Ser Gln Pro Glu Ser Ser Thr Xaa Pro His Pro Thr Pro Val Ser
 145                 150                 155                 160
 Ala Ala Ser Ser Ser Pro Ala Pro Glu Ser Ser Cys His Asp Glu Leu
                 165                 170                 175    
 Gly Leu Leu Ser Leu Asn Leu Pro Ala Pro Gly Pro Pro Lys Pro Thr
             180                 185                 190        
 Pro Gly Ala Ala Ala Ser Phe Gln Gly Ser Gly
         195                 200            



      <210> 2492
      <211> 80
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(80)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2492
 Met Asn Arg Gly Gly Phe Ala Val Lys Ile Leu Ala Leu Leu Asp Ala
   1               5                  10                  15    
 Leu Ser Thr Val Cys Ser Gln Arg Val Gln Lys Ala Lys Lys Gln Gln
              20                  25                  30        
 His Leu Gln Asn Lys Glu His Phe Lys Ala Leu Leu Lys Gln Lys Glu
          35                  40                  45            
 Lys Leu Lys Gln Gln Glu Asp Leu Arg Lys Lys Leu Phe Xaa Ile Gln
      50                  55                  60                
 Gly Ile Arg Cys Pro Gln Ala Thr Pro His His Gly Gln Cys Ser Leu
  65                  70                  75                  80





      <210> 2493
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 2493
 Arg Ser Phe Val Leu Asp Thr Ala Ser Ala Ile Cys Asn Tyr Asn Ala
   1               5                  10                  15    
 His Tyr Lys Asn His Pro Lys Tyr Trp Cys Arg Gly Tyr Phe Arg Asp
              20                  25                  30        
 Tyr Cys Asn Ile Ile Ala Phe Ser Pro Asn Ser Thr Asn His Val Ala
          35                  40                  45            
 Leu Arg Asp Thr Gly Asn Gln Leu Ile Val Thr Met Ser Cys Leu Thr
      50                  55                  60                
 Lys Glu Asp Thr Gly Trp Tyr Trp Cys Gly Ile Gln Arg Asp Phe Ala
  65                  70                  75                  80
 Arg Asp Asp Met Asp Phe Thr Glu Leu Ile Val Thr Asp Asp Lys Gly
                  85                  90                  95    
 Thr Leu Ala Asn Asp Phe Trp Ser Gly Lys Asp Leu Ser Gly Asn Lys
             100                 105                 110        
 Thr Arg Ser Cys Lys Ala Pro Lys Val Val Arg Lys Ala Asp Arg Ser
         115                 120                 125            
 Arg Thr Ser Ile Leu Ile Ile Cys Ile Leu Ile Thr Gly Leu Gly Ile
     130                 135                 140                
 Ile Ser Val Ile Ser His Leu Thr Lys Arg Arg Arg Ser Gln Arg Asn
 145                 150                 155                 160
 Arg Arg Val Gly Asn Thr Leu Lys Pro Phe Ser Arg Val Leu Thr Pro
                 165                 170                 175    
 Lys Glu Met Ala Pro Thr Glu Gln Met
             180                 185



      <210> 2494
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 2494
 Met Trp Ser Leu Trp Ile Trp Val Asp Gln His Gln Ala Arg Leu Ile
   1               5                  10                  15    
 Pro Ser Pro Gln Val Leu Leu Leu Leu Leu Arg Glu Thr Pro Ser Thr
              20                  25                  30        
 Ala Ala Ala Val Ala Gly Trp Leu Val Val Ala Ser Met Ala Leu Leu
          35                  40                  45            
 Gln Leu His Ala Val Gly Gly Val Ala Leu Thr Ser Ser His Pro Phe
      50                  55                  60                
 Met Trp Ala Thr Gly Glu Glu Leu Arg Lys Pro Pro Trp Gln Gly Ser
  65                  70                  75                  80
 Ala Gly Ser Ala Ser Gly Val Glu Glu Leu Thr Gly Lys His Ser Cys
                  85                  90                  95    
 Pro Gly Pro Glu Glu Pro Ala Thr Val Gln Lys Ala Pro Ala
             100                 105                 110



      <210> 2495
      <211> 223
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(223)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2495
 Thr Phe Thr Gln Pro Asp Pro Asp Asp Leu Ile Ser Lys Pro Pro Arg
   1               5                  10                  15    
 Thr Pro Gly Gly Gly Xaa Tyr Gln Thr Gln Trp Pro Ser Pro Pro Asp
              20                  25                  30        
 Pro Arg Arg Thr Ser Pro Ala Gly Arg Pro Gly Pro Ala Arg Arg Pro
          35                  40                  45            
 Pro Arg Arg Thr Pro Arg Pro Ala Arg Gly Arg His Pro Gly Arg Xaa
      50                  55                  60                
 Gly Gly Pro Gly Ala Ser Arg Pro Gly Gly Thr Gly Ala Ala Pro Ala
  65                  70                  75                  80
 Ala Asp Gln Thr Gly Ser Pro Ala Val Ser Thr Pro Ser Glu Phe Gly
                  85                  90                  95    
 Ala Pro Gly Gln Ala Glu Gly Pro Gln Ser Pro Ile Arg Ala Ser Ala
             100                 105                 110        
 Arg Ser His Leu Ser Cys Thr Ala Trp Leu Gly Lys Pro Ser Lys Pro
         115                 120                 125            
 Ser Ala Gln Arg Gln Pro Thr Val Gly Pro Asp Gly Asp Arg Asp Gly
     130                 135                 140                
 Ser Ser Gln Ala Pro Asn Leu Ser Arg Gly Gln Ala Trp Arg Ala Ser
 145                 150                 155                 160
 Leu Ala Ser Pro Gln Asn Thr Ser Ala Thr Gly Arg Val Thr Cys His
                 165                 170                 175    
 Gly Gln Ser Thr Trp Pro Leu Cys Arg Leu Lys Ser Asn Arg Arg Arg
             180                 185                 190        
 Lys Ser Gly Phe Ala Gly Asn Lys Ser Glu Pro Val Gly Leu Thr Arg
         195                 200                 205            
 Arg Ser Lys His Gln Pro Arg Asn Pro Gln Gly Gln Val Gly Ile
     210                 215                 220            



      <210> 2496
      <211> 223
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(223)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2496
 Thr Phe Thr Gln Pro Asp Pro Asp Asp Leu Ile Ser Lys Pro Pro Arg
   1               5                  10                  15    
 Thr Pro Gly Gly Gly Xaa Tyr Gln Thr Gln Trp Pro Ser Pro Pro Asp
              20                  25                  30        
 Pro Arg Arg Thr Ser Pro Ala Gly Arg Pro Gly Pro Ala Arg Arg Pro
          35                  40                  45            
 Pro Arg Arg Thr Pro Arg Pro Ala Arg Gly Arg His Pro Gly Arg Xaa
      50                  55                  60                
 Gly Gly Pro Gly Ala Ser Arg Pro Gly Gly Thr Gly Ala Ala Pro Ala
  65                  70                  75                  80
 Ala Asp Gln Thr Gly Ser Pro Ala Val Ser Thr Pro Ser Glu Phe Gly
                  85                  90                  95    
 Ala Pro Gly Gln Ala Glu Gly Pro Gln Ser Pro Ile Arg Ala Ser Ala
             100                 105                 110        
 Arg Ser His Leu Ser Cys Thr Ala Trp Leu Gly Lys Pro Ser Lys Pro
         115                 120                 125            
 Ser Ala Gln Arg Gln Pro Thr Val Gly Pro Asp Gly Asp Arg Asp Gly
     130                 135                 140                
 Ser Ser Gln Ala Pro Asn Leu Ser Arg Gly Gln Ala Trp Arg Ala Ser
 145                 150                 155                 160
 Leu Ala Ser Pro Gln Asn Thr Ser Ala Thr Gly Arg Val Thr Cys His
                 165                 170                 175    
 Gly Gln Ser Thr Trp Pro Leu Cys Arg Leu Lys Ser Asn Arg Arg Arg
             180                 185                 190        
 Lys Ser Gly Phe Ala Gly Asn Lys Ser Glu Pro Val Gly Leu Thr Arg
         195                 200                 205            
 Arg Ser Lys His Gln Pro Arg Asn Pro Gln Gly Gln Val Gly Ile
     210                 215                 220            



      <210> 2497
      <211> 223
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(223)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2497
 Thr Phe Thr Gln Pro Asp Pro Asp Asp Leu Ile Ser Lys Pro Pro Arg
   1               5                  10                  15    
 Thr Pro Gly Gly Gly Xaa Tyr Gln Thr Gln Trp Pro Ser Pro Pro Asp
              20                  25                  30        
 Pro Arg Arg Thr Ser Pro Ala Gly Arg Pro Gly Pro Ala Arg Arg Pro
          35                  40                  45            
 Pro Arg Arg Thr Pro Arg Pro Ala Arg Gly Arg His Pro Gly Arg Xaa
      50                  55                  60                
 Gly Gly Pro Gly Ala Ser Arg Pro Gly Gly Thr Gly Ala Ala Pro Ala
  65                  70                  75                  80
 Ala Asp Gln Thr Gly Ser Pro Ala Val Ser Thr Pro Ser Glu Phe Gly
                  85                  90                  95    
 Ala Pro Gly Gln Ala Glu Gly Pro Gln Ser Pro Ile Arg Ala Ser Ala
             100                 105                 110        
 Arg Ser His Leu Ser Cys Thr Ala Trp Leu Gly Lys Pro Ser Lys Pro
         115                 120                 125            
 Ser Ala Gln Arg Gln Pro Thr Val Gly Pro Asp Gly Asp Arg Asp Gly
     130                 135                 140                
 Ser Ser Gln Ala Pro Asn Leu Ser Arg Gly Gln Ala Trp Arg Ala Ser
 145                 150                 155                 160
 Leu Ala Ser Pro Gln Asn Thr Ser Ala Thr Gly Arg Val Thr Cys His
                 165                 170                 175    
 Gly Gln Ser Thr Trp Pro Leu Cys Arg Leu Lys Ser Asn Arg Arg Arg
             180                 185                 190        
 Lys Ser Gly Phe Ala Gly Asn Lys Ser Glu Pro Val Gly Leu Thr Arg
         195                 200                 205            
 Arg Ser Lys His Gln Pro Arg Asn Pro Gln Gly Gln Val Gly Ile
     210                 215                 220            



      <210> 2498
      <211> 534
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(534)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2498
 Pro Pro Gly Thr Gln Gly Ser Pro Gln Arg Thr Gly Asp His Gly Gly
   1               5                  10                  15    
 Lys Pro Pro Leu Pro Ala Glu Lys Pro Ala Pro Gly Pro Gly Leu Pro
              20                  25                  30        
 Ala Arg Ala Ser Arg Ala Glu Gly Arg Gly Ala Ser Gly Trp Lys Pro
          35                  40                  45            
 Gly Gly Gln Pro Ala Gly Gly Ser Trp Gln Gly Gly Asp Ala Gly Pro
      50                  55                  60                
 Arg Arg Pro Ala Ser Gly Asp Gln Arg Thr Ala Gly Ala Ala Lys Ala
  65                  70                  75                  80
 Leu Ala Gly Pro Ala Gly Glu Ala Ala Gly Gly Asp Arg Gly Ala Ala
                  85                  90                  95    
 Gln Gly Asp Pro Pro Ala Glu Ala Gly Gly Arg Gly Gly Xaa Thr Gln
             100                 105                 110        
 Ala Gly Gly Gly Ala Ser Arg Ala Arg Gly Ser Gly Ala Gln Arg Pro
         115                 120                 125            
 Gly Gly Pro Xaa Arg Gln Gly Gln Gly Asp Gly Gly Glu Ser Ala Ser
     130                 135                 140                
 Pro Ala Phe Gly Pro Cys Pro Gln Ser Ser Trp Gly Pro Pro Cys Ser
 145                 150                 155                 160
 Ile Pro Gly Pro Xaa Pro Ala Leu Pro Gly Ala Leu Xaa Gly Ala Val
                 165                 170                 175    
 Gly Arg Asp Pro Ala Gly Pro Pro Asp Gly Gly Pro Asp Thr Glu Pro
             180                 185                 190        
 Pro Gly Ser Pro Gly Gln Ala Glu Arg Trp Pro Glu Gly Cys Arg Pro
         195                 200                 205            
 Gln Gly Ser Trp His Cys Glu Gly Ala Pro Gln Gly Pro Gly Ala Gly
     210                 215                 220                
 Ala Arg Ala Arg Pro Arg Gln Gly Ser Arg Gly Pro Arg Gly Ala Pro
 225                 230                 235                 240
 Arg Arg Gly Ile Pro Trp Ala Lys Ser Gly Arg Thr Gly Gly Ser Gln
                 245                 250                 255    
 Asp Arg Lys Lys Pro Gly Lys Glu Val Ala Ala Thr Gly Thr Ser Ile
             260                 265                 270        
 Pro Glu Gly Ser Gln Leu Ala Arg Gly Arg Ala Arg Ser Arg Asp Gly
         275                 280                 285            
 Gly Pro Ser His Glu Ala Gln Ala Ser Glu Pro Arg Pro Gly Pro Cys
     290                 295                 300                
 Ser Gly Pro Ala Arg Trp Gly Gly Arg Ser Ser Cys Thr Ala Pro Gly
 305                 310                 315                 320
 Cys Val Thr Pro Ala Gly Thr Ala Gly His Leu Xaa Trp Arg Ala Gly
                 325                 330                 335    
 Trp Thr Ala Gly Pro Pro Ala Gly Pro Trp Arg Ser Pro Gly Asp Glu
             340                 345                 350        
 Lys Gly Pro Arg Gly Gly Pro Cys Ala Cys Val Pro Arg Ala Ala Glu
         355                 360                 365            
 Arg Arg Gly Gly Arg Cys Cys Pro Gly Ala Gln Ala Glu Ala Arg Ala
     370                 375                 380                
 Arg Ala Gly Ala Gln Thr Ser Cys Pro Gly Gly Pro Glu Ala Gly Gln
 385                 390                 395                 400
 Cys Gln Ala Gln Pro Gly Pro Glu Thr Ala Gly Trp Leu Arg Pro Pro
                 405                 410                 415    
 Glu Ala Thr Ala Gly Pro Trp Pro Ser Cys Arg Gly Ser Ala Gly Pro
             420                 425                 430        
 Glu Gly Trp Gly His His Trp Pro Xaa Pro Pro Ala Xaa Cys Pro Gly
         435                 440                 445            
 Glu Arg Pro Pro Trp Arg Pro Gly Cys Pro Ala Pro Pro Gly Cys Gly
     450                 455                 460                
 Gly Ser Ser Ala Gly Gly Pro Gln Pro Ala Ala Xaa Thr Gly Ala Trp
 465                 470                 475                 480
 Ala Ser Arg Gly Val Leu Ala Pro Ala Gly His Glu Gly His Ala Ser
                 485                 490                 495    
 His Cys Pro Pro Arg Pro Ala Ala Gly Leu Ser Gln Pro His Pro Ser
             500                 505                 510        
 Gln Thr Leu Glu Val Thr Leu Ala Ser Pro Gln Gly Phe Met Ser Glu
         515                 520                 525            
 Ala Leu Thr Lys Cys Glu
     530                



      <210> 2499
      <211> 251
      <212> PRT
      <213> Homo sapiens


      <400> 2499
 Ser Leu Arg Thr Pro Gly Phe Arg Gly Gly Gly Val Leu Tyr Trp Asp
   1               5                  10                  15    
 Ala Gly Ala Ala Gly Thr Gly Ser Asn His Ala Leu Gly Ala Asn Val
              20                  25                  30        
 Glu Leu Trp Ile Met Leu Leu Gln Val Val Arg Glu Gly Lys Phe Ser
          35                  40                  45            
 Gly Phe Leu Thr Ser Cys Ser Leu Leu Leu Pro Arg Ala Ala Gln Ile
      50                  55                  60                
 Leu Ala Ala Glu Ala Gly Leu Pro Ser Ser Arg Ser Phe Met Gly Phe
  65                  70                  75                  80
 Ala Ala Pro Phe Thr Asn Lys Arg Lys Ala Tyr Ser Glu Arg Arg Ile
                  85                  90                  95    
 Met Gly Tyr Ser Met Gln Glu Met Tyr Glu Val Val Ser Asn Val Gln
             100                 105                 110        
 Glu Tyr Arg Glu Phe Val Pro Trp Gly Lys Lys Ser Leu Val Val Ser
         115                 120                 125            
 Ser Arg Lys Gly His Leu Lys Ala Gln Leu Glu Val Gly Phe Pro Pro
     130                 135                 140                
 Val Met Glu Arg Tyr Thr Ser Ala Val Ser Met Val Lys Pro His Met
 145                 150                 155                 160
 Val Lys Ala Val Cys Thr Asp Gly Lys Leu Phe Asn His Leu Glu Thr
                 165                 170                 175    
 Ile Trp Arg Phe Ser Pro Gly Ile Pro Ala Tyr Pro Arg Thr Cys Thr
             180                 185                 190        
 Val Asp Phe Ser Ile Ser Phe Glu Phe Arg Ser Leu Leu His Ser Gln
         195                 200                 205            
 Leu Ala Thr Met Phe Phe Asp Glu Val Val Lys Gln Asn Val Ala Ala
     210                 215                 220                
 Phe Glu Arg Arg Ala Ala Thr Lys Phe Gly Pro Glu Thr Ala Ile Pro
 225                 230                 235                 240
 Arg Glu Leu Met Phe His Glu Val His Gln Thr
                 245                 250    



      <210> 2500
      <211> 89
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(89)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2500
 Cys Cys Leu Ala Ala His Ser Gly Pro Pro Ala Gln Gly Gln Arg Arg
   1               5                  10                  15    
 Gly Pro Gly Xaa Leu Cys Cys Ser Ala Gly Ser Gly Gly Asn Leu Xaa
              20                  25                  30        
 Ser Xaa Ala Gly Gly Pro Gly Xaa Gly Arg Ser Gly Gln Pro Val Cys
          35                  40                  45            
 Pro Pro Trp Pro Gly Pro Gly Ala Pro Gly His Arg Pro Ala Leu Pro
      50                  55                  60                
 Gly Ser Gly Gly Ser Ser Ala Val Gly Arg Ser Ala Val Pro Gly Ala
  65                  70                  75                  80
 Val Arg Ser Pro Ser His Ala Gly Trp
                  85                



      <210> 2501
      <211> 295
      <212> PRT
      <213> Homo sapiens


      <400> 2501
 Arg Gln Glu Gln Gly His Phe His Phe Phe Cys Gly Gly Met Ser Ser
   1               5                  10                  15    
 Phe Lys Ala Gly Thr Ser His Leu Asp Val Tyr Met Gln Val Thr Glu
              20                  25                  30        
 Gly Arg Glu Asp Tyr Asn Pro Ser Met His Leu Ala Lys Arg Gln Phe
          35                  40                  45            
 Leu Ser Leu Glu Glu Glu Ala Glu Asp Tyr Asn Pro Ser Gln His Arg
      50                  55                  60                
 Ala Gln Gly Asn Trp Leu Gln Asp Tyr Asn Ala Ser Met Gln Arg Val
  65                  70                  75                  80
 His Gly Gln Cys Val Ser Leu Glu Glu Asp Val Glu Leu Cys Val Pro
                  85                  90                  95    
 Arg Trp Ala Cys Arg Glu Met Gln Ser His Asn Tyr Pro Ser Arg Leu
             100                 105                 110        
 Val Ala Gly Leu Gln Gln Tyr Asn Phe Ser Ile Ser Leu Ala Gln Gly
         115                 120                 125            
 Glu Cys Thr Ser His Trp Arg Lys Arg Gly Ile Met Thr Tyr Ser Ser
     130                 135                 140                
 Ile His Cys Leu Gly Asp Val Thr Leu His Ser Tyr Leu Gly Pro Ser
 145                 150                 155                 160
 Lys Thr Glu Asp Cys Asp Ile Ser Val Thr Leu Pro Pro Arg Leu Glu
                 165                 170                 175    
 Arg Arg Ile Thr Leu Pro Lys His Trp Ile Lys Lys Tyr Phe Thr Ile
             180                 185                 190        
 Phe Leu Met Gly Lys Ala Gln Ile Asn Lys Ile Asp Arg Pro Leu Val
         195                 200                 205            
 Arg Gln Ile Lys Glu Lys Arg Glu Lys Asn Gln Arg Asp Ala Ile Lys
     210                 215                 220                
 Asn Asp Lys Gly Asp Ile Thr Thr Lys Pro Thr Glu Ile Gln Thr Thr
 225                 230                 235                 240
 Ile Arg Glu Tyr Tyr Lys His Leu Tyr Gly Asn Lys Val Glu Asn Leu
                 245                 250                 255    
 Glu Glu Ile Asp Lys Phe Leu Glu Thr Ser Thr Pro Pro Arg Leu Asn
             260                 265                 270        
 Glu Glu Glu Val Glu Ser Leu Ser Arg Pro Ile Ala Gly Ser Glu Ile
         275                 280                 285            
 Glu Ala Ile Ile Asn Ser Leu
     290                 295



      <210> 2502
      <211> 475
      <212> PRT
      <213> Homo sapiens


      <400> 2502
 Met Gly Ser Arg Val Arg Leu Ser Lys Arg Arg Ala Lys Ala Gly Val
   1               5                  10                  15    
 Gln Ser Gly Thr Asn Ala Leu Leu Val Val Lys His Arg Asp Met Asn
              20                  25                  30        
 Glu Lys Glu Leu Glu Ala Gln Glu Ala Arg Lys Ala Gln Leu Glu Asn
          35                  40                  45            
 His Glu Pro Glu Glu Glu Glu Glu Glu Glu Ile Arg Gln Pro Arg Lys
      50                  55                  60                
 Lys Leu Gly Ala Gln Pro Val Val His Trp Val Ala Pro Asp Gly Arg
  65                  70                  75                  80
 Leu Leu Gly Asn Ser Ser Arg Thr Arg Val Arg Gly Asp Gly Thr Leu
                  85                  90                  95    
 Asp Val Thr Ile Thr Thr Leu Arg Asp Ser Gly Thr Phe Thr Cys Ile
             100                 105                 110        
 Ala Ser Asn Ala Ala Gly Glu Ala Thr Ala Pro Val Glu Pro Arg Gly
         115                 120                 125            
 Leu Cys Pro Asp Tyr Ala Cys Thr Arg Phe Ser Thr Thr Val Pro Leu
     130                 135                 140                
 Met Thr Pro Ser Ser Thr Gly Val Asp Ile Glu Ala Ala Arg Lys Glu
 145                 150                 155                 160
 Glu Glu Arg Ile Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly
                 165                 170                 175    
 His Ile Asn Asp Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His
             180                 185                 190        
 Val Ala Ala Ala Lys Gly Tyr Thr Glu Val Leu Lys Ile Ile Ser Leu
         195                 200                 205            
 Arg Phe Gly Val Pro Arg Thr Gln Val Arg Thr Trp Val Ala Leu Tyr
     210                 215                 220                
 Glu Lys His Gly Glu Lys Gly Leu Ile Pro Lys Pro Lys Gly Val Ser
 225                 230                 235                 240
 Ala Asp Pro Glu Leu Arg Ile Lys Val Val Lys Ala Val Ile Glu Gln
                 245                 250                 255    
 His Met Ser Leu Asn Gln Ala Ala Ala His Phe Met Leu Ala Gly Ser
             260                 265                 270        
 Gly Ser Val Ala Arg Trp Leu Lys Val Tyr Glu Glu Arg Gly Glu Ala
         275                 280                 285            
 Gly Leu Arg Ala Leu Lys Ile Gly Thr Lys Arg Asn Ile Ala Ile Ser
     290                 295                 300                
 Val Asp Pro Glu Lys Ala Ala Ser Ala Leu Glu Leu Ser Lys Asp Arg
 305                 310                 315                 320
 Arg Ile Glu Asp Leu Glu Arg Gln Val Arg Phe Leu Glu Thr Arg Leu
                 325                 330                 335    
 Met Tyr Leu Lys Lys Leu Lys Ala Leu Ala His Pro Thr Lys Lys Ala
             340                 345                 350        
 Ala Glu Ile Pro Arg Ser Thr Phe Tyr Tyr His Leu Lys Ala Leu Ser
         355                 360                 365            
 Lys Pro Asp Lys Tyr Ala Asp Val Lys Lys Arg Ile Ser Glu Ile Tyr
     370                 375                 380                
 His Glu Asn Arg Gly Arg Tyr Gly Tyr Arg Arg Val Thr Leu Ser Leu
 385                 390                 395                 400
 His Arg Glu Gly Lys Gln Ile Asn His Lys Ala Val Gln Arg Leu Met
                 405                 410                 415    
 Gly Thr Leu Ser His Lys Ala Ala Ile Lys Val Lys Arg Tyr Arg Ser
             420                 425                 430        
 Tyr Arg Gly Glu Met Lys Lys Leu Arg Ile Arg Glu Val Gln Ile Leu
         435                 440                 445            
 Ala Gly Gly His Thr Ala Lys Leu Asn Met Glu Gln Val Lys Ser Ala
     450                 455                 460                
 Asp Ala Phe Thr Tyr Ile Lys Gln Pro Ile Ala
 465                 470                 475



      <210> 2503
      <211> 66
      <212> PRT
      <213> Homo sapiens


      <400> 2503
 Met Arg Cys Arg Ala Pro Ala Trp Leu Arg Arg Leu Cys Gly Gln Leu
   1               5                  10                  15    
 Leu Ser Glu Arg Leu Met Arg Pro Asn Gly Val Gln Ala Val Val Arg
              20                  25                  30        
 Gly Ile Leu Glu Gly Ala Gly Ala Gly Ala Ala Gly Gly Ser Asp Ala
          35                  40                  45            
 Glu Val Thr Ala Ala Asp Trp Lys Lys Cys Asp Leu Ile Ala Lys Ile
      50                  55                  60                
 Leu Ala
  65    



      <210> 2504
      <211> 255
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(255)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2504
 Ser Trp Ala Thr Ala Gly Ala Ala Asn Gly Pro Ala Pro Leu Gly Val
   1               5                  10                  15    
 Arg Ala Pro Pro Ala Trp Arg Thr Ser Pro Ala Ala Glu Met Gly Ala
              20                  25                  30        
 Thr Gly Ala Ala Glu Pro Leu Gln Ser Val Leu Trp Val Lys Gln Gln
          35                  40                  45            
 Arg Cys Ala Val Ser Leu Glu Pro Ala Arg Ala Leu Leu Arg Trp Trp
      50                  55                  60                
 Arg Ser Pro Gly Pro Gly Ala Gly Ala Pro Gly Ala Asp Ala Cys Ser
  65                  70                  75                  80
 Val Pro Val Ser Glu Ile Ile Ala Val Glu Glu Thr Asp Val His Gly
                  85                  90                  95    
 Lys His Gln Gly Ser Gly Lys Trp Gln Lys Met Glu Lys Pro Tyr Ala
             100                 105                 110        
 Phe Thr Val His Cys Val Lys Arg Ala Arg Arg His Arg Trp Lys Trp
         115                 120                 125            
 Ala Gln Val Thr Phe Trp Cys Pro Glu Glu Gln Leu Cys His Leu Trp
     130                 135                 140                
 Leu Gln Thr Leu Arg Glu Met Leu Glu Lys Leu Thr Ser Arg Pro Lys
 145                 150                 155                 160
 His Leu Leu Val Phe Ile Asn Pro Phe Gly Gly Lys Gly Gln Gly Lys
                 165                 170                 175    
 Arg Ile Tyr Glu Arg Lys Val Ala Pro Leu Phe Thr Leu Ala Ser Ile
             180                 185                 190        
 Thr Thr Asp Ile Ile Val Thr Glu His Ala Asn Gln Ala Lys Glu Thr
         195                 200                 205            
 Leu Tyr Glu Ile Asn Ile Asp Lys Tyr Asp Gly Xaa Val Arg Arg Pro
     210                 215                 220                
 Ser Ala Ser Ala Arg Pro Gln Pro Gly Gly Arg Ala Arg Arg Arg Arg
 225                 230                 235                 240
 Trp Gly Arg Arg Gly Arg Arg Ser Arg Cys Asn Pro Cys Cys Gly
                 245                 250                 255



      <210> 2505
      <211> 256
      <212> PRT
      <213> Homo sapiens


      <400> 2505
 Met Lys Arg Glu Arg Gly Ala Leu Ser Arg Ala Ser Arg Ala Leu Arg
   1               5                  10                  15    
 Leu Ala Pro Phe Val Tyr Leu Leu Leu Ile Gln Thr Asp Pro Leu Glu
              20                  25                  30        
 Gly Val Asn Ile Thr Ser Pro Val Arg Leu Ile His Gly Thr Val Gly
          35                  40                  45            
 Lys Ser Ala Leu Leu Ser Val Gln Tyr Ser Ser Thr Ser Ser Asp Arg
      50                  55                  60                
 Pro Val Val Lys Trp Gln Leu Lys Arg Asp Lys Pro Val Thr Val Val
  65                  70                  75                  80
 Gln Ser Ile Gly Thr Glu Val Ile Gly Thr Leu Arg Pro Asp Tyr Arg
                  85                  90                  95    
 Asp Arg Ile Arg Leu Phe Glu Asn Gly Ser Leu Leu Leu Ser Asp Leu
             100                 105                 110        
 Gln Leu Ala Asp Glu Gly Thr Tyr Glu Val Glu Ile Ser Ile Thr Asp
         115                 120                 125            
 Asp Thr Phe Thr Gly Glu Lys Thr Ile Asn Leu Thr Val Asp Val Pro
     130                 135                 140                
 Ile Ser Arg Pro Gln Val Leu Gly Ala Ser Thr Thr Val Leu Glu Leu
 145                 150                 155                 160
 Ser Glu Ala Phe Thr Leu Asn Cys Ser His Glu Asn Gly Thr Lys Pro
                 165                 170                 175    
 Ser Tyr Thr Trp Leu Lys Asp Gly Lys Pro Leu Leu Asn Asp Ser Arg
             180                 185                 190        
 Met Leu Leu Ser Pro Asp Gln Lys Val Leu Thr Ile Thr Arg Val Leu
         195                 200                 205            
 Met Glu Asp Asp Asp Leu Tyr Ser Cys Val Val Glu Asn Pro Ile Asn
     210                 215                 220                
 Gln Gly Arg Thr Leu Pro Cys Lys Ile Thr Glu Tyr Arg Lys Ser Ser
 225                 230                 235                 240
 Leu Ser Ser Ile Trp Leu Gln Glu Ala Phe Ser Ser Leu Gly Pro Trp
                 245                 250                 255    





      <210> 2506
      <211> 256
      <212> PRT
      <213> Homo sapiens


      <400> 2506
 Met Lys Arg Glu Arg Gly Ala Leu Ser Arg Ala Ser Arg Ala Leu Arg
   1               5                  10                  15    
 Leu Ala Pro Phe Val Tyr Leu Leu Leu Ile Gln Thr Asp Pro Leu Glu
              20                  25                  30        
 Gly Val Asn Ile Thr Ser Pro Val Arg Leu Ile His Gly Thr Val Gly
          35                  40                  45            
 Lys Ser Ala Leu Leu Ser Val Gln Tyr Ser Ser Thr Ser Ser Asp Arg
      50                  55                  60                
 Pro Val Val Lys Trp Gln Leu Lys Arg Asp Lys Pro Val Thr Val Val
  65                  70                  75                  80
 Gln Ser Ile Gly Thr Glu Val Ile Gly Thr Leu Arg Pro Asp Tyr Arg
                  85                  90                  95    
 Asp Arg Ile Arg Leu Phe Glu Asn Gly Ser Leu Leu Leu Ser Asp Leu
             100                 105                 110        
 Gln Leu Ala Asp Glu Gly Thr Tyr Glu Val Glu Ile Ser Ile Thr Asp
         115                 120                 125            
 Asp Thr Phe Thr Gly Glu Lys Thr Ile Asn Leu Thr Val Asp Val Pro
     130                 135                 140                
 Ile Ser Arg Pro Gln Val Leu Gly Ala Ser Thr Thr Val Leu Glu Leu
 145                 150                 155                 160
 Ser Glu Ala Phe Thr Leu Asn Cys Ser His Glu Asn Gly Thr Lys Pro
                 165                 170                 175    
 Ser Tyr Thr Trp Leu Lys Asp Gly Lys Pro Leu Leu Asn Asp Ser Arg
             180                 185                 190        
 Met Leu Leu Ser Pro Asp Gln Lys Val Leu Thr Ile Thr Arg Val Leu
         195                 200                 205            
 Met Glu Asp Asp Asp Leu Tyr Ser Cys Val Val Glu Asn Pro Ile Asn
     210                 215                 220                
 Gln Gly Arg Thr Leu Pro Cys Lys Ile Thr Glu Tyr Arg Lys Ser Ser
 225                 230                 235                 240
 Leu Ser Ser Ile Trp Leu Gln Glu Ala Phe Ser Ser Leu Gly Pro Trp
                 245                 250                 255    





      <210> 2507
      <211> 664
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(664)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2507
 Val Ser Lys Thr Thr Thr Thr Asn Ala Gly Asn Ala Leu Phe Pro Met
   1               5                  10                  15    
 Pro Gly Ser Ser Lys Thr Lys Lys Pro Asn Ser His Gln Arg Gly Gln
              20                  25                  30        
 Met Gly Ser Xaa Gly Arg Asn Pro Pro Ser Leu Gly Arg Ala Pro Ala
          35                  40                  45            
 Pro Leu Pro Glu Arg Glu Ala Pro Ile Pro Ala Pro Gln Leu Gly Pro
      50                  55                  60                
 Ser Ala Ala Gly Thr Ser Arg Gln Val Gly Gln Lys Ser Ser Thr Ser
  65                  70                  75                  80
 Pro His Gln Gly Glu Glu Ala Ile Leu Asn Arg Glu Leu Lys Lys Lys
                  85                  90                  95    
 Asp Gly Lys Lys Lys Xaa Lys Lys Pro Thr Gly Leu Ser Lys His Gln
             100                 105                 110        
 Pro Ala Gly Phe Ile Gln Asn Glu Xaa Asn Leu Lys Gly Ala Gly Glu
         115                 120                 125            
 Phe Val Gln Gly Leu Ala Gly Ser Gln Asn Pro Pro Ser Ser Lys Leu
     130                 135                 140                
 Gln Gly Leu Gly Gly Ser Ala Glu Ser Arg Gly Phe Ser Arg Gly Gln
 145                 150                 155                 160
 Gly Gln Thr Ala Pro His Trp Glu Ser Thr Pro Leu Lys Gly Ala Leu
                 165                 170                 175    
 Pro Pro Cys Pro Glu Arg Gly Met Leu Pro Glu Glu Gly Xaa Gly Phe
             180                 185                 190        
 Ser Gly Lys Glu Ala Ser Ser Gly Pro Val Gln Pro Gln Pro Thr Cys
         195                 200                 205            
 Leu Tyr Gly Ile Arg Pro Ser Leu Gly Ser Xaa Pro Xaa Gly Gln Arg
     210                 215                 220                
 Arg Thr Leu Leu Ala Pro Thr Phe Leu Gln Glu Asn Gln Leu Ser Gly
 225                 230                 235                 240
 Pro Ser Pro Gly Gln Arg Ala Arg Ser Val Leu Arg Pro Phe Ser Ala
                 245                 250                 255    
 Pro Gly Leu Arg Pro Glu Leu Glu Leu Thr Gly Gly Arg Gly Ser Thr
             260                 265                 270        
 Arg Ser Arg Arg Ala Ala Gly Pro Trp Ala Ser Asp Cys Thr Ala Gly
         275                 280                 285            
 Ser Asp Gln Glu Ser Leu Gly Arg Ser Ser Gly Lys Gly Arg Xaa Gly
     290                 295                 300                
 Ala Ser Gly Thr Val Leu Gly Val Ser Met Cys Lys Val Pro Gly Cys
 305                 310                 315                 320
 Lys Ala Ala Gly Gly His Leu Pro Gly Gly Gly Arg Gly Leu Asp Leu
                 325                 330                 335    
 Glu Cys Gly Trp Gly Leu Arg Ser Trp Leu Pro Gly Arg Gly Arg Gln
             340                 345                 350        
 Thr Gly Pro Pro Gly Pro Gln Gly Arg Asp Ser Xaa Ser Thr Lys Gln
         355                 360                 365            
 Ser Asp Ser His Arg Trp Gln Asp Ser Gly Gly Gly Leu Ala Pro Pro
     370                 375                 380                
 Pro Pro Gly Gln Gly Asn Asn Gly Ala Arg Pro Cys Cys Xaa Asp Val
 385                 390                 395                 400
 Thr Lys Ala Ser Ala Pro Gly Val Ser Gly Asp Thr Gly Arg Glu Ala
                 405                 410                 415    
 Pro Ser Ala Thr Gly Ile Ser Thr Phe Arg Ser Cys Cys Met Ser Ser
             420                 425                 430        
 Ala Arg Gly Leu Gly Gln Ser Pro Ala Ala Pro Val Leu Ala Ser Ser
         435                 440                 445            
 Phe Leu Pro Thr Ser Cys Thr Gly Pro Pro Gly Leu Pro Gly Leu Pro
     450                 455                 460                
 Ser Ser Gly Ser Glu Glu Asn Ile His Ser Gly Ala Trp Ala Leu Val
 465                 470                 475                 480
 Gly Gln Glu Gly Pro Ser Met Asp Gly Arg Gly Asn Gly Met Met Leu
                 485                 490                 495    
 Arg Gly Val Trp Thr Gly Val His Gly Gly Gly Met Asp Gly Cys Gly
             500                 505                 510        
 Ala Glu Val Ile Xaa Arg Gly Lys Phe Leu Met Glu Xaa Tyr Arg Ser
         515                 520                 525            
 Gly Leu Gln Arg Lys Gln Asp Ser Ser Pro Ala Arg Thr Pro Ala Pro
     530                 535                 540                
 Gln Trp Leu Ser Ile Thr Thr Gly Ser Xaa Thr Pro Glu Gly Asp Pro
 545                 550                 555                 560
 Gly Gly Lys Leu Asp Ala Ala Gln Arg Gly Arg Ala Ile Ala Ala His
                 565                 570                 575    
 Gly Thr Ala Gly Gly Cys Cys Pro Arg Cys Cys Cys His Leu Xaa Ser
             580                 585                 590        
 Pro Gly Ser Ala Arg Ser Ser Pro Pro Met Ala Ser Ala Ser Ile Arg
         595                 600                 605            
 Val Ser Pro Pro Arg Ser Gly Gly Ser Pro Pro Ser Pro Ser Ser Ala
     610                 615                 620                
 Xaa Lys Ser Asp Arg Thr Asp Ala Gly Ala Gly Val Ala Ala Ala Ala
 625                 630                 635                 640
 Ser Pro Gly Ala Gly Ala Pro Ala His Cys Pro Gln Gly Pro Pro Arg
                 645                 650                 655    
 Ser Cys Gln Gly Pro Gln Arg Arg
             660                



      <210> 2508
      <211> 319
      <212> PRT
      <213> Homo sapiens


      <400> 2508
 Met Glu Thr Ser Ser Pro Arg Pro Pro Arg Pro Ser Ser Asn Pro Gly
   1               5                  10                  15    
 Leu Ser Leu Asp Ala Arg Leu Gly Val Asp Thr His Leu Trp Ala Lys
              20                  25                  30        
 Val Leu Phe Thr Ala Leu Tyr Ala Leu Ile Trp Ala Leu Gly Ala Ala
          35                  40                  45            
 Gly Asn Ala Leu Ser Val His Val Val Leu Lys Ala Arg Ala Gly Arg
      50                  55                  60                
 Ala Gly Arg Leu Arg His His Val Leu Ser Leu Ala Leu Ala Gly Leu
  65                  70                  75                  80
 Leu Leu Leu Leu Val Gly Val Pro Val Glu Leu Tyr Ser Phe Val Trp
                  85                  90                  95    
 Phe His Tyr Pro Trp Val Phe Arg Asp Leu Gly Cys Arg Gly Tyr Tyr
             100                 105                 110        
 Phe Val His Glu Leu Cys Ala Tyr Ala Thr Val Leu Ser Val Ala Gly
         115                 120                 125            
 Leu Ser Ala Glu Arg Cys Leu Ala Val Cys Gln Pro Leu Arg Ala Arg
     130                 135                 140                
 Ser Leu Leu Thr Pro Arg Arg Thr Arg Trp Leu Val Ala Leu Ser Trp
 145                 150                 155                 160
 Ala Ala Ser Leu Gly Leu Ala Leu Pro Met Ala Val Ile Met Gly Gln
                 165                 170                 175    
 Lys His Glu Leu Glu Thr Ala Asp Gly Glu Pro Glu Pro Ala Ser Arg
             180                 185                 190        
 Val Cys Thr Val Leu Val Ser Arg Thr Ala Leu Gln Val Phe Ile Gln
         195                 200                 205            
 Glu Ala Ile Val Val Met Tyr Val Ile Cys Trp Leu Pro Tyr His Ala
     210                 215                 220                
 Arg Arg Leu Met Tyr Cys Tyr Val Pro Asp Asp Ala Trp Thr Asp Pro
 225                 230                 235                 240
 Leu Tyr Asn Phe Tyr His Tyr Phe Tyr Met Val Thr Asn Thr Leu Phe
                 245                 250                 255    
 Tyr Val Ser Ser Ala Val Thr Pro Leu Leu Tyr Asn Ala Val Ser Ser
             260                 265                 270        
 Ser Phe Arg Lys Leu Phe Leu Glu Ala Val Ser Ser Leu Cys Gly Glu
         275                 280                 285            
 His His Pro Met Lys Arg Leu Pro Pro Lys Pro Gln Ser Pro Thr Leu
     290                 295                 300                
 Met Asp Thr Ala Ser Gly Phe Gly Asp Pro Pro Glu Thr Arg Thr
 305                 310                 315                



      <210> 2509
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 2509
 Asp Val Glu Val Lys Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu
   1               5                  10                  15    
 Ile Gln Trp Ile Arg His His Val Thr Thr Met Ser Glu Arg Thr Phe
              20                  25                  30        
 Pro Asn Asn Pro Val Glu Leu Lys Val Ser Val Thr Val Glu Ile Thr
          35                  40                  45            





      <210> 2510
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 2510
 Asp Val Glu Val Lys Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu
   1               5                  10                  15    
 Ile Gln Trp Ile Arg His His Val Thr Thr Met Ser Glu Arg Thr Phe
              20                  25                  30        
 Pro Asn Asn Pro Val Glu Leu Lys Val Ser Val Thr Val Glu Ile Thr
          35                  40                  45            





      <210> 2511
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 2511
 Arg Ser Leu Pro Pro Ala His Ser Val Ser Leu Trp Ser Val Lys Asp
   1               5                  10                  15    
 Gly Leu Arg Pro Trp His Pro Glu Leu Arg Ser Val Gln Pro Thr Arg
              20                  25                  30        
 Gly Gly Arg Thr Gln Thr His Arg Arg Gly Ala Ala Pro Gly Ile Ser
          35                  40                  45            
 Thr Pro His Thr Leu Gly Gly Arg Ala Ser Ala Ala Arg Arg Pro Trp
      50                  55                  60                
 His Thr Cys Gly Arg Gln Arg Arg Pro Pro Arg Arg Arg Arg Glu Arg
  65                  70                  75                  80
 Arg Pro Leu Tyr Ser Ser Val Leu Arg Ser Thr
                  85                  90    



      <210> 2512
      <211> 466
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(466)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2512
 Arg Gln Glu Asn Asn Thr Arg Gly Val Pro Ser Leu Leu Lys Ser Phe
   1               5                  10                  15    
 Leu Gln Glu Arg Leu Gly Ile His Leu Ile Arg Arg Lys Ile Val Lys
              20                  25                  30        
 Pro Lys His His Val Leu Met Ser Arg Lys Glu Ser Trp Lys Val Lys
          35                  40                  45            
 Ser Glu Ile Pro Lys Val Pro Lys Gln Pro Leu Val Leu His His Pro
      50                  55                  60                
 Arg Met Thr Thr Thr Lys Ser Pro Ser Lys Asp Met Leu Glu Pro Glu
  65                  70                  75                  80
 Ala Glu Leu Ala Glu Asp Leu Pro Thr Thr Lys Ser Thr Ser Val Glu
                  85                  90                  95    
 Ser Glu Asp Ala His Xaa Glu Pro Gly Arg Pro Phe Pro Val Leu Pro
             100                 105                 110        
 Asp Leu Pro Cys His Cys Leu Pro Ser Ala Pro Thr Pro Leu Cys Ile
         115                 120                 125            
 Val Lys Arg Pro Cys Pro Thr Xaa Val Thr Gln Leu Ser Ala Ser Ala
     130                 135                 140                
 Gln Ser Ala His Gln Met Arg Thr Pro Arg Ala Gln Ser Pro Ser Ser
 145                 150                 155                 160
 Xaa Pro Arg Xaa Val Asn Cys Leu Pro Pro Ser Leu His Lys Asp Asp
                 165                 170                 175    
 Leu Glu Leu Lys Glu Lys Asp Gln Lys Lys Pro Pro Thr Ala Pro Arg
             180                 185                 190        
 Glu Val Lys Gly Thr Arg Arg Lys Leu Pro Thr Ala Phe Leu Pro Ser
         195                 200                 205            
 Lys Tyr His Gly Tyr Glu Glu Leu Leu Thr Ala Lys Pro Asp Pro Ala
     210                 215                 220                
 Phe Ile Glu Pro Lys Gly Ile Gln Lys Asn Ala Pro Ser Pro Ala Thr
 225                 230                 235                 240
 Asn Ala Glu Ala Pro Thr Pro Val Pro Leu Leu Gln Ala Gln Ala Gly
                 245                 250                 255    
 His Ser Ser Glu Thr Leu Cys Ser Gln Arg Glu Thr Gly Pro Glu Asn
             260                 265                 270        
 Pro Asp Ser Thr Pro Lys Glu Asp Xaa Ser Pro Thr Ser Gly Xaa His
         275                 280                 285            
 Leu His Ser Leu Ala Gly Ser Pro Glu His Tyr Arg Gly Ser Thr Arg
     290                 295                 300                
 Cys Cys Pro Ala Pro Val Asp Arg Thr Ala Ala Gly Glu Pro Ala Ser
 305                 310                 315                 320
 Ser Thr Trp Arg Pro Arg Gly Cys Xaa Arg Ser Ser Arg His Val Thr
                 325                 330                 335    
 Gly Ser Trp Xaa Val Ala Leu Cys Ala Gln Cys Ser Gly Leu Pro Arg
             340                 345                 350        
 Ser Pro Trp Pro Ala Gln Arg Xaa Val Arg Ala Ser Pro Ser Ser Ala
         355                 360                 365            
 Thr Ser Ser Ser Ser Trp Met Ser Ser Ala Arg Ser Pro Gln Pro Val
     370                 375                 380                
 Thr His Lys Ala Arg Ala Val His Gly Gly Cys Val His His Pro Ala
 385                 390                 395                 400
 Cys Ala Pro Ala Leu Pro Glu Gly Ser Val Pro Trp Thr Ala Pro Gln
                 405                 410                 415    
 Gly Xaa Pro Ala Gly His Arg Pro Gln Ser Ser Ala Gly Pro His Leu
             420                 425                 430        
 Leu Ala Thr Arg Trp His Pro Leu Val Arg Ile Ser Pro Pro Trp Pro
         435                 440                 445            
 Arg His Asp Leu Val Pro Gly Pro Ala Ala Ile Lys Ser Gly Cys Thr
     450                 455                 460                
 Gly Gln
 465    



      <210> 2513
      <211> 466
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(466)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2513
 Arg Gln Glu Asn Asn Thr Arg Gly Val Pro Ser Leu Leu Lys Ser Phe
   1               5                  10                  15    
 Leu Gln Glu Arg Leu Gly Ile His Leu Ile Arg Arg Lys Ile Val Lys
              20                  25                  30        
 Pro Lys His His Val Leu Met Ser Arg Lys Glu Ser Trp Lys Val Lys
          35                  40                  45            
 Ser Glu Ile Pro Lys Val Pro Lys Gln Pro Leu Val Leu His His Pro
      50                  55                  60                
 Arg Met Thr Thr Thr Lys Ser Pro Ser Lys Asp Met Leu Glu Pro Glu
  65                  70                  75                  80
 Ala Glu Leu Ala Glu Asp Leu Pro Thr Thr Lys Ser Thr Ser Val Glu
                  85                  90                  95    
 Ser Glu Asp Ala His Xaa Glu Pro Gly Arg Pro Phe Pro Val Leu Pro
             100                 105                 110        
 Asp Leu Pro Cys His Cys Leu Pro Ser Ala Pro Thr Pro Leu Cys Ile
         115                 120                 125            
 Val Lys Arg Pro Cys Pro Thr Xaa Val Thr Gln Leu Ser Ala Ser Ala
     130                 135                 140                
 Gln Ser Ala His Gln Met Arg Thr Pro Arg Ala Gln Ser Pro Ser Ser
 145                 150                 155                 160
 Xaa Pro Arg Xaa Val Asn Cys Leu Pro Pro Ser Leu His Lys Asp Asp
                 165                 170                 175    
 Leu Glu Leu Lys Glu Lys Asp Gln Lys Lys Pro Pro Thr Ala Pro Arg
             180                 185                 190        
 Glu Val Lys Gly Thr Arg Arg Lys Leu Pro Thr Ala Phe Leu Pro Ser
         195                 200                 205            
 Lys Tyr His Gly Tyr Glu Glu Leu Leu Thr Ala Lys Pro Asp Pro Ala
     210                 215                 220                
 Phe Ile Glu Pro Lys Gly Ile Gln Lys Asn Ala Pro Ser Pro Ala Thr
 225                 230                 235                 240
 Asn Ala Glu Ala Pro Thr Pro Val Pro Leu Leu Gln Ala Gln Ala Gly
                 245                 250                 255    
 His Ser Ser Glu Thr Leu Cys Ser Gln Arg Glu Thr Gly Pro Glu Asn
             260                 265                 270        
 Pro Asp Ser Thr Pro Lys Glu Asp Xaa Ser Pro Thr Ser Gly Xaa His
         275                 280                 285            
 Leu His Ser Leu Ala Gly Ser Pro Glu His Tyr Arg Gly Ser Thr Arg
     290                 295                 300                
 Cys Cys Pro Ala Pro Val Asp Arg Thr Ala Ala Gly Glu Pro Ala Ser
 305                 310                 315                 320
 Ser Thr Trp Arg Pro Arg Gly Cys Xaa Arg Ser Ser Arg His Val Thr
                 325                 330                 335    
 Gly Ser Trp Xaa Val Ala Leu Cys Ala Gln Cys Ser Gly Leu Pro Arg
             340                 345                 350        
 Ser Pro Trp Pro Ala Gln Arg Xaa Val Arg Ala Ser Pro Ser Ser Ala
         355                 360                 365            
 Thr Ser Ser Ser Ser Trp Met Ser Ser Ala Arg Ser Pro Gln Pro Val
     370                 375                 380                
 Thr His Lys Ala Arg Ala Val His Gly Gly Cys Val His His Pro Ala
 385                 390                 395                 400
 Cys Ala Pro Ala Leu Pro Glu Gly Ser Val Pro Trp Thr Ala Pro Gln
                 405                 410                 415    
 Gly Xaa Pro Ala Gly His Arg Pro Gln Ser Ser Ala Gly Pro His Leu
             420                 425                 430        
 Leu Ala Thr Arg Trp His Pro Leu Val Arg Ile Ser Pro Pro Trp Pro
         435                 440                 445            
 Arg His Asp Leu Val Pro Gly Pro Ala Ala Ile Lys Ser Gly Cys Thr
     450                 455                 460                
 Gly Gln
 465    



      <210> 2514
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 2514
 His Gly Leu Cys Glu Leu Thr Ser Thr Val Gln Glu Gly Glu Leu Cys
   1               5                  10                  15    
 Val Phe Phe Arg Asn Asn His Phe Ser Thr Met Thr Lys Tyr Lys Gly
              20                  25                  30        
 Gln Leu Tyr Leu Leu Val Thr Asp Gln Gly Phe Leu Thr Glu Glu Lys
          35                  40                  45            
 Val Val Trp Glu Ser Leu His Asn Val Asp Gly Asp Gly Asn Phe Cys
      50                  55                  60                
 Asp Ser Glu Phe His Leu Arg Pro Pro Ser Asp Pro Glu Thr Val Tyr
  65                  70                  75                  80
 Lys Gly Gln Gln Asp Gln Ile Asp Gln Asp Tyr Leu Met Ala Leu Ser
                  85                  90                  95    
 Leu Gln Gln Glu Gln Gln Ser Gln Glu Ile Asn Trp Glu Gln Ile Pro
             100                 105                 110        
 Glu Gly Ile Ser Asp Leu Glu Leu Ala Lys Lys Leu Gln Glu Glu Glu
         115                 120                 125            
 Asp Arg Arg Ala Ser Gln Tyr Tyr Gln Glu Gln Glu Gln Ala Ala Ala
     130                 135                 140                
 Ala Ala Ala Ala Ala Ser Thr Gln Ala Gln Gln Gly Gln Pro Ala Gln
 145                 150                 155                 160
 Ala Ser Pro Ser Ser Gly Arg Gln Ser Gly Asn Ser Glu Arg Lys Arg
                 165                 170                 175    
 Lys Glu Pro Arg Glu Lys Asp Lys Glu Lys Glu Lys Glu Lys Asn Ser
             180                 185                 190        
 Cys Val Ile Leu
         195    



      <210> 2515
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 2515
 His Gly Leu Cys Glu Leu Thr Ser Thr Val Gln Glu Gly Glu Leu Cys
   1               5                  10                  15    
 Val Phe Phe Arg Asn Asn His Phe Ser Thr Met Thr Lys Tyr Lys Gly
              20                  25                  30        
 Gln Leu Tyr Leu Leu Val Thr Asp Gln Gly Phe Leu Thr Glu Glu Lys
          35                  40                  45            
 Val Val Trp Glu Ser Leu His Asn Val Asp Gly Asp Gly Asn Phe Cys
      50                  55                  60                
 Asp Ser Glu Phe His Leu Arg Pro Pro Ser Asp Pro Glu Thr Val Tyr
  65                  70                  75                  80
 Lys Gly Gln Gln Asp Gln Ile Asp Gln Asp Tyr Leu Met Ala Leu Ser
                  85                  90                  95    
 Leu Gln Gln Glu Gln Gln Ser Gln Glu Ile Asn Trp Glu Gln Ile Pro
             100                 105                 110        
 Glu Gly Ile Ser Asp Leu Glu Leu Ala Lys Lys Leu Gln Glu Glu Glu
         115                 120                 125            
 Asp Arg Arg Ala Ser Gln Tyr Tyr Gln Glu Gln Glu Gln Ala Ala Ala
     130                 135                 140                
 Ala Ala Ala Ala Ala Ser Thr Gln Ala Gln Gln Gly Gln Pro Ala Gln
 145                 150                 155                 160
 Ala Ser Pro Ser Ser Gly Arg Gln Ser Gly Asn Ser Glu Arg Lys Arg
                 165                 170                 175    
 Lys Glu Pro Arg Glu Lys Asp Lys Glu Lys Glu Lys Glu Lys Asn Ser
             180                 185                 190        
 Cys Val Ile Leu
         195    



      <210> 2516
      <211> 250
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(250)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2516
 Lys Ala Cys Leu His Leu Leu Ser Ser Phe Leu Thr Ser Asn Phe Leu
   1               5                  10                  15    
 Phe Asn Pro Leu Leu Pro Asp Ser Leu Tyr Ser Val Glu Ala Arg Ser
              20                  25                  30        
 Gln Arg Ala Asn Leu Gly Pro Cys Arg Arg Lys Arg Leu Gln Thr Leu
          35                  40                  45            
 Met Arg Leu Ala Ala Gly Phe Gln Tyr Ser Ser His Lys Asp Pro Ser
      50                  55                  60                
 Leu Ser Ala Lys Glu Lys His Thr Asp Tyr His Asn Glu Ala Arg Gly
  65                  70                  75                  80
 Pro Trp Pro Gly Trp Val Gly Xaa Arg Thr Ala Asp Gly Ser Cys Gly
                  85                  90                  95    
 Arg Gly Pro Asp Gly Ala His His Pro Gly Pro Lys Ser Ser Ser Trp
             100                 105                 110        
 Arg Ala Ser Arg Leu Leu Pro Gly Leu Gly Gly Ser His His Leu Asp
         115                 120                 125            
 Ala Tyr Val Gly Arg Asp Leu Glu Cys Gly Thr Pro Ala Pro Leu Gln
     130                 135                 140                
 Leu Glu Ile Pro Pro Gln Pro Arg Gly His Pro Ala Pro Ile Pro Thr
 145                 150                 155                 160
 Gly Gln Ala Gly Pro Arg Asp Ser Gly Pro Gly Ala Ser Pro Xaa Val
                 165                 170                 175    
 Glu Thr Arg Pro Leu Thr Asp Gly Arg Arg Xaa Pro Gly Val Arg Pro
             180                 185                 190        
 Val Gly Trp Thr Pro Ala His Pro Ala Gly Thr Leu Arg Pro Arg Gly
         195                 200                 205            
 Ala Val Glu Pro Ser Val Ser Ala Cys Gly Lys Trp Ala Pro Ser Pro
     210                 215                 220                
 Thr Ser Gln Gly Cys Cys Glu Gly Arg Cys Asp Ala Val Pro Lys His
 225                 230                 235                 240
 Arg Ala Trp Arg Thr Pro Leu Cys Ser Gln
                 245                 250



      <210> 2517
      <211> 577
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(577)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2517
 Gln Asn Glu Asn Ser Val Asp Lys Trp Gly Lys Pro Leu Val Ile Asp
   1               5                  10                  15    
 Lys Leu Lys Glu Met Ala Lys Val Glu Gly Leu Trp Asn Leu Phe Leu
              20                  25                  30        
 Pro Ala Val Ser Gly Leu Ser His Val Asp Tyr Ala Leu Ile Ala Glu
          35                  40                  45            
 Glu Thr Gly Lys Cys Phe Phe Ala Pro Asp Val Phe Asn Cys Gln Ala
      50                  55                  60                
 Pro Asp Thr Gly Asn Met Glu Val Leu His Leu Tyr Gly Ser Glu Glu
  65                  70                  75                  80
 Gln Lys Lys Gln Trp Leu Glu Pro Leu Leu Gln Gly Asn Ile Thr Ser
                  85                  90                  95    
 Cys Phe Cys Met Thr Glu Pro Asp Val Ala Ser Ser Asp Ala Thr Asn
             100                 105                 110        
 Ile Glu Cys Ser Ile Gln Arg Asp Glu Asp Ser Tyr Val Ile Asn Gly
         115                 120                 125            
 Lys Lys Trp Trp Ser Ser Gly Ala Gly Asn Pro Lys Cys Lys Ile Ala
     130                 135                 140                
 Ile Val Leu Gly Arg Thr Gln Asn Thr Ser Leu Ser Arg Xaa Leu Asn
 145                 150                 155                 160
 Asn Ser Asp Xaa Glu Thr Cys Val Gly Met Ser Gln Ser Ser Ser Tyr
                 165                 170                 175    
 Leu Gly Asn Leu Leu Lys Ile His Cys Leu Asp Ser Gln Ile Ile Met
             180                 185                 190        
 Xaa Asp Met Arg Val Asn Val Ile Tyr Leu Tyr Phe Thr Ser Ile Phe
         195                 200                 205            
 Xaa Gln Val Phe Leu Glu Asn Ile Ile Gly Ser Ile Ala Glu His Ser
     210                 215                 220                
 Ser Leu Trp Asn Phe Gln Tyr Xaa Lys Val Leu Leu Asn Tyr Gln Ser
 225                 230                 235                 240
 Cys Leu Asp Xaa Ile Ile Arg Gln Ile Phe Ser Asp Leu Cys Asn Glu
                 245                 250                 255    
 Val Ile Arg Cys Leu Asp Gln Arg Gln Xaa Ser Xaa Asn Val Xaa Leu
             260                 265                 270        
 Tyr Ile Xaa Val Pro Ser Tyr His Cys Xaa Ala Val Arg Ser Phe Asn
         275                 280                 285            
 Gln Thr Thr His Leu Phe Ser Asn His Cys Phe Cys Ser Arg Ser Gln
     290                 295                 300                
 Pro Ala Ser Asp Tyr Val Gly Val Arg Leu Leu His Ser Ser His Ser
 305                 310                 315                 320
 Ser His His Cys Leu His Asp Tyr Met Lys Thr Ser Lys Arg Gln Leu
                 325                 330                 335    
 Gly Phe Cys Leu Leu Ser Val Leu Phe Phe Phe Leu Ala Asn Phe Phe
             340                 345                 350        
 Xaa Tyr Asn Phe Ser Phe Asp Xaa His Lys Gln His Ser Met Ile Leu
         355                 360                 365            
 Val Pro Met Asn Thr Pro Gly Val Lys Ile Ile Arg Pro Leu Ser Val
     370                 375                 380                
 Phe Gly Tyr Thr Asp Asn Phe His Gly Gly His Phe Glu Ile His Phe
 385                 390                 395                 400
 Asn Gln Val Arg Val Pro Ala Thr Asn Leu Ile Leu Gly Glu Gly Arg
                 405                 410                 415    
 Gly Phe Glu Ile Ser Gln Gly Arg Leu Gly Pro Gly Arg Ile His His
             420                 425                 430        
 Cys Met Arg Thr Val Gly Leu Ala Glu Arg Ala Leu Gln Ile Met Cys
         435                 440                 445            
 Glu Arg Ala Thr Gln Arg Ile Ala Phe Lys Lys Lys Leu Tyr Ala His
     450                 455                 460                
 Glu Val Val Ala His Trp Ile Ala Glu Ser Arg Ile Ala Ile Glu Lys
 465                 470                 475                 480
 Ile Arg Leu Leu Thr Leu Lys Ala Ala His Ser Met Asp Thr Leu Gly
                 485                 490                 495    
 Ser Ala Gly Ala Lys Lys Glu Ile Ala Met Ile Lys Val Ala Ala Pro
             500                 505                 510        
 Arg Ala Val Ser Lys Ile Val Asp Trp Ala Ile Gln Val Cys Gly Gly
         515                 520                 525            
 Ala Gly Val Ser Gln Asp Tyr Pro Leu Ala Asn Met Tyr Ala Ile Thr
     530                 535                 540                
 Arg Val Leu Arg Leu Ala Asp Gly Pro Asp Glu Val His Leu Ser Ala
 545                 550                 555                 560
 Ile Ala Thr Met Glu Leu Arg Asp Gln Ala Lys Arg Leu Thr Ala Lys
                 565                 570                 575    
 Ile
    



      <210> 2518
      <211> 577
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(577)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2518
 Gln Asn Glu Asn Ser Val Asp Lys Trp Gly Lys Pro Leu Val Ile Asp
   1               5                  10                  15    
 Lys Leu Lys Glu Met Ala Lys Val Glu Gly Leu Trp Asn Leu Phe Leu
              20                  25                  30        
 Pro Ala Val Ser Gly Leu Ser His Val Asp Tyr Ala Leu Ile Ala Glu
          35                  40                  45            
 Glu Thr Gly Lys Cys Phe Phe Ala Pro Asp Val Phe Asn Cys Gln Ala
      50                  55                  60                
 Pro Asp Thr Gly Asn Met Glu Val Leu His Leu Tyr Gly Ser Glu Glu
  65                  70                  75                  80
 Gln Lys Lys Gln Trp Leu Glu Pro Leu Leu Gln Gly Asn Ile Thr Ser
                  85                  90                  95    
 Cys Phe Cys Met Thr Glu Pro Asp Val Ala Ser Ser Asp Ala Thr Asn
             100                 105                 110        
 Ile Glu Cys Ser Ile Gln Arg Asp Glu Asp Ser Tyr Val Ile Asn Gly
         115                 120                 125            
 Lys Lys Trp Trp Ser Ser Gly Ala Gly Asn Pro Lys Cys Lys Ile Ala
     130                 135                 140                
 Ile Val Leu Gly Arg Thr Gln Asn Thr Ser Leu Ser Arg Xaa Leu Asn
 145                 150                 155                 160
 Asn Ser Asp Xaa Glu Thr Cys Val Gly Met Ser Gln Ser Ser Ser Tyr
                 165                 170                 175    
 Leu Gly Asn Leu Leu Lys Ile His Cys Leu Asp Ser Gln Ile Ile Met
             180                 185                 190        
 Xaa Asp Met Arg Val Asn Val Ile Tyr Leu Tyr Phe Thr Ser Ile Phe
         195                 200                 205            
 Xaa Gln Val Phe Leu Glu Asn Ile Ile Gly Ser Ile Ala Glu His Ser
     210                 215                 220                
 Ser Leu Trp Asn Phe Gln Tyr Xaa Lys Val Leu Leu Asn Tyr Gln Ser
 225                 230                 235                 240
 Cys Leu Asp Xaa Ile Ile Arg Gln Ile Phe Ser Asp Leu Cys Asn Glu
                 245                 250                 255    
 Val Ile Arg Cys Leu Asp Gln Arg Gln Xaa Ser Xaa Asn Val Xaa Leu
             260                 265                 270        
 Tyr Ile Xaa Val Pro Ser Tyr His Cys Xaa Ala Val Arg Ser Phe Asn
         275                 280                 285            
 Gln Thr Thr His Leu Phe Ser Asn His Cys Phe Cys Ser Arg Ser Gln
     290                 295                 300                
 Pro Ala Ser Asp Tyr Val Gly Val Arg Leu Leu His Ser Ser His Ser
 305                 310                 315                 320
 Ser His His Cys Leu His Asp Tyr Met Lys Thr Ser Lys Arg Gln Leu
                 325                 330                 335    
 Gly Phe Cys Leu Leu Ser Val Leu Phe Phe Phe Leu Ala Asn Phe Phe
             340                 345                 350        
 Xaa Tyr Asn Phe Ser Phe Asp Xaa His Lys Gln His Ser Met Ile Leu
         355                 360                 365            
 Val Pro Met Asn Thr Pro Gly Val Lys Ile Ile Arg Pro Leu Ser Val
     370                 375                 380                
 Phe Gly Tyr Thr Asp Asn Phe His Gly Gly His Phe Glu Ile His Phe
 385                 390                 395                 400
 Asn Gln Val Arg Val Pro Ala Thr Asn Leu Ile Leu Gly Glu Gly Arg
                 405                 410                 415    
 Gly Phe Glu Ile Ser Gln Gly Arg Leu Gly Pro Gly Arg Ile His His
             420                 425                 430        
 Cys Met Arg Thr Val Gly Leu Ala Glu Arg Ala Leu Gln Ile Met Cys
         435                 440                 445            
 Glu Arg Ala Thr Gln Arg Ile Ala Phe Lys Lys Lys Leu Tyr Ala His
     450                 455                 460                
 Glu Val Val Ala His Trp Ile Ala Glu Ser Arg Ile Ala Ile Glu Lys
 465                 470                 475                 480
 Ile Arg Leu Leu Thr Leu Lys Ala Ala His Ser Met Asp Thr Leu Gly
                 485                 490                 495    
 Ser Ala Gly Ala Lys Lys Glu Ile Ala Met Ile Lys Val Ala Ala Pro
             500                 505                 510        
 Arg Ala Val Ser Lys Ile Val Asp Trp Ala Ile Gln Val Cys Gly Gly
         515                 520                 525            
 Ala Gly Val Ser Gln Asp Tyr Pro Leu Ala Asn Met Tyr Ala Ile Thr
     530                 535                 540                
 Arg Val Leu Arg Leu Ala Asp Gly Pro Asp Glu Val His Leu Ser Ala
 545                 550                 555                 560
 Ile Ala Thr Met Glu Leu Arg Asp Gln Ala Lys Arg Leu Thr Ala Lys
                 565                 570                 575    
 Ile
    



      <210> 2519
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 2519
 Phe Gly Val Ile Asn Leu Ile Cys Thr Gly Phe Leu Leu Met Trp Cys
   1               5                  10                  15    
 Ser Ser Thr Asn Ser Ile Ala Leu Thr Ser Tyr Thr Tyr Leu Thr Ile
              20                  25                  30        
 Phe Asp Leu Phe Ser Leu Met Thr Cys Leu Ile Ser Tyr Trp Val Thr
          35                  40                  45            
 Leu Arg Lys Pro Ser Pro Val Tyr Ser Phe Gly Phe Glu Arg Leu Glu
      50                  55                  60                
 Val Leu Ala Val Phe Ala Ser Thr Val Leu Ala Gln Leu Gly Ala Leu
  65                  70                  75                  80
 Phe Ile Leu Lys Glu Ser Ala Glu Arg Phe Leu Glu Gln Pro Glu Ile
                  85                  90                  95    
 His Thr Gly Arg Leu Leu Val Gly Thr Phe Val Ala Leu Cys Phe Asn
             100                 105                 110        
 Leu Phe Thr Met Leu Ser Ile Arg Asn Lys Pro Phe Ala Tyr Val Ser
         115                 120                 125            
 Glu Ala Ala Ser Thr Ser Trp Leu Gln Glu His Val Ala Asp Leu Ser
     130                 135                 140                
 Arg Ser Leu Cys Gly Ile Ile Pro Gly Leu Ser Ser Ile Phe Leu Pro
 145                 150                 155                 160
 Arg Met Asn Pro Phe Val Leu Ile Asp Leu Ala Gly Ala Phe Ala Leu
                 165                 170                 175    
 Cys Ile Thr Tyr Met Leu
             180        



      <210> 2520
      <211> 625
      <212> PRT
      <213> Homo sapiens


      <400> 2520
 Arg Ala Pro Met Met Thr Lys Ala Val Pro Glu Glu Pro Arg Lys Pro
   1               5                  10                  15    
 Gly Arg Leu Thr Gln Ala Leu Asn Ser Pro Leu Thr Trp Glu His Val
              20                  25                  30        
 Trp Ile Cys Val Pro Gly Gly Thr Pro Asp Cys Leu Thr Asp Thr Phe
          35                  40                  45            
 Arg Val Lys Arg Pro His Leu Arg Arg Ser Ala Ser Asn Gly His Val
      50                  55                  60                
 Pro Gly Thr Pro Val Tyr Arg Glu Lys Glu Asp Met Tyr Asp Glu Ile
  65                  70                  75                  80
 Ile Glu Leu Lys Lys Ser Leu His Val Gln Lys Ser Asp Val Asp Leu
                  85                  90                  95    
 Met Arg Thr Lys Leu Arg Arg Leu Glu Glu Glu Asn Ser Arg Lys Asp
             100                 105                 110        
 Arg Gln Ile Glu Gln Leu Leu Asp Pro Ser Arg Gly Thr Asp Phe Val
         115                 120                 125            
 Arg Thr Leu Ala Glu Lys Arg Pro Asp Ala Ser Trp Val Ile Asn Gly
     130                 135                 140                
 Leu Lys Gln Arg Ile Leu Lys Leu Glu Gln Gln Cys Lys Glu Lys Asp
 145                 150                 155                 160
 Gly Thr Ile Ser Lys Leu Gln Thr Asp Met Lys Thr Thr Asn Leu Glu
                 165                 170                 175    
 Glu Met Arg Ile Ala Met Glu Thr Tyr Tyr Glu Glu Val His Arg Leu
             180                 185                 190        
 Gln Thr Leu Leu Ala Ser Ser Glu Thr Thr Gly Lys Lys Pro Leu Gly
         195                 200                 205            
 Glu Lys Lys Thr Gly Ala Lys Arg Gln Lys Lys Met Gly Ser Ala Leu
     210                 215                 220                
 Leu Ser Leu Ser Arg Ser Val Gln Glu Leu Thr Glu Glu Asn Gln Ser
 225                 230                 235                 240
 Leu Lys Glu Asp Leu Asp Arg Val Leu Ser Thr Ser Pro Thr Ile Ser
                 245                 250                 255    
 Lys Thr Gln Gly Tyr Val Glu Trp Ser Lys Pro Arg Leu Leu Arg Arg
             260                 265                 270        
 Ile Val Glu Leu Glu Lys Lys Leu Ser Val Met Glu Ser Ser Lys Ser
         275                 280                 285            
 His Ala Ala Glu Pro Val Arg Ser His Pro Pro Ala Cys Leu Ala Ser
     290                 295                 300                
 Ser Ser Ala Leu His Arg Gln Pro Arg Gly Asp Arg Asn Lys Asp His
 305                 310                 315                 320
 Glu Arg Leu Arg Gly Ala Val Arg Asp Leu Lys Glu Glu Arg Thr Ala
                 325                 330                 335    
 Leu Gln Glu Gln Leu Leu Gln Arg Asp Leu Glu Val Lys Gln Leu Leu
             340                 345                 350        
 Gln Ala Lys Ala Asp Leu Glu Lys Glu Leu Glu Cys Ala Arg Glu Gly
         355                 360                 365            
 Glu Glu Glu Arg Arg Glu Arg Glu Glu Val Leu Arg Glu Glu Ile Gln
     370                 375                 380                
 Thr Leu Thr Ser Lys Leu Gln Glu Leu Gln Glu Met Lys Lys Glu Glu
 385                 390                 395                 400
 Lys Glu Asp Cys Pro Glu Val Pro His Lys Ala Gln Glu Leu Pro Ala
                 405                 410                 415    
 Pro Thr Pro Ser Ser Arg His Cys Glu Gln Asp Trp Pro Pro Asp Ser
             420                 425                 430        
 Ser Glu Glu Gly Leu Pro Arg Pro Arg Ser Pro Cys Ser Asp Gly Arg
         435                 440                 445            
 Arg Asp Ala Ala Ala Arg Val Leu Gln Ala Gln Trp Lys Val Tyr Lys
     450                 455                 460                
 His Lys Lys Lys Lys Ala Val Leu Asp Glu Ala Ala Val Val Leu Gln
 465                 470                 475                 480
 Ala Ala Phe Arg Gly His Leu Thr Arg Thr Lys Leu Leu Ala Ser Lys
                 485                 490                 495    
 Ala His Gly Ser Glu Pro Pro Ser Val Pro Gly Leu Pro Asp Gln Ser
             500                 505                 510        
 Ser Pro Val Pro Arg Val Pro Ser Pro Ile Ala Gln Ala Thr Gly Ser
         515                 520                 525            
 Pro Val Gln Glu Glu Ala Ile Val Ile Ile Gln Ser Ala Leu Arg Ala
     530                 535                 540                
 His Leu Ala Arg Ala Arg His Ser Ala Thr Gly Lys Arg Thr Thr Thr
 545                 550                 555                 560
 Ala Ala Ser Thr Arg Arg Arg Ser Ala Ser Ala Thr His Gly Asp Ala
                 565                 570                 575    
 Ser Ser Pro Pro Phe Leu Ala Ala Leu Pro Asp Pro Ser Pro Ser Gly
             580                 585                 590        
 Pro Gln Ala Val Ala Pro Leu Pro Gly Asp Asp Val Asn Ser Asp Asp
         595                 600                 605            
 Ser Asp Asp Ile Val Ile Ala Pro Ser Leu Pro Thr Lys Asn Phe Pro
     610                 615                 620                
 Val
 625



      <210> 2521
      <211> 519
      <212> PRT
      <213> Homo sapiens


      <400> 2521
 Ala Pro Ala Arg Arg Gly Leu Gly Asp Arg Cys Ser Ser Ser Ser Phe
   1               5                  10                  15    
 Ser Ser Ser Phe Phe Ser Ser Ala Ser Ser Pro Arg Arg Leu Ala Thr
              20                  25                  30        
 Ala Ala Ala Arg Ala Gly Gly Ala Ala Val Ile Pro Val Pro Glu Glu
          35                  40                  45            
 Pro Ala Leu Pro Val Pro Gly Gly Arg Gly Ala Gly Glu Ala Gly Pro
      50                  55                  60                
 Arg Arg Thr Gln Gln Val Glu Pro Gly Val Pro Gly Arg Ala Pro Pro
  65                  70                  75                  80
 Ala His His Ala Ala Leu Cys His Leu Ser Arg Pro Gln Ala Lys Ile
                  85                  90                  95    
 Leu Ser Met Met Glu Asp Asn Lys Gln Leu Ala Leu Arg Ile Asp Gly
             100                 105                 110        
 Ala Val Gln Ser Ala Ser Gln Glu Val Thr Asn Leu Arg Ala Glu Leu
         115                 120                 125            
 Thr Ala Thr Asn Arg Arg Leu Ala Glu Leu Ser Gly Gly Gly Gly Pro
     130                 135                 140                
 Gly Pro Gly Pro Gly Ala Ala Ala Ser Ala Ser Ala Ala Gly Asp Ser
 145                 150                 155                 160
 Ala Ala Thr Asn Met Glu Asn Pro Gln Leu Gly Ala Gln Val Leu Leu
                 165                 170                 175    
 Arg Glu Glu Val Ser Arg Leu Gln Glu Glu Val His Leu Leu Arg Gln
             180                 185                 190        
 Met Lys Glu Met Leu Ala Lys Asp Leu Glu Glu Ser Gln Gly Gly Lys
         195                 200                 205            
 Ser Ser Glu Val Leu Ser Ala Thr Glu Leu Arg Val Gln Leu Ala Gln
     210                 215                 220                
 Lys Glu Gln Glu Leu Ala Arg Ala Lys Glu Ala Leu Gln Ala Met Lys
 225                 230                 235                 240
 Ala Asp Arg Lys Arg Leu Lys Gly Glu Lys Thr Asp Leu Val Ser Gln
                 245                 250                 255    
 Met Gln Gln Leu Tyr Ala Thr Leu Glu Ser Arg Glu Glu Gln Leu Arg
             260                 265                 270        
 Asp Phe Ile Arg Asn Tyr Glu Gln His Arg Lys Glu Ser Glu Asp Ala
         275                 280                 285            
 Val Lys Ala Leu Ala Lys Glu Lys Asp Leu Leu Glu Arg Glu Lys Trp
     290                 295                 300                
 Glu Leu Arg Arg Gln Ala Lys Glu Ala Thr Asp His Ala Thr Ala Leu
 305                 310                 315                 320
 Arg Ser Gln Leu Asp Leu Lys Asp Asn Arg Met Lys Glu Leu Glu Ala
                 325                 330                 335    
 Glu Leu Ala Met Ala Lys Gln Ser Leu Ala Thr Leu Thr Lys Asp Val
             340                 345                 350        
 Pro Lys Arg His Ser Leu Ala Met Pro Gly Glu Thr Val Leu Asn Gly
         355                 360                 365            
 Asn Gln Glu Trp Val Val Gln Ala Asp Leu Pro Leu Thr Ala Ala Ile
     370                 375                 380                
 Arg Gln Ser Gln Gln Thr Leu Tyr His Ser His Pro Pro His Pro Ala
 385                 390                 395                 400
 Asp Arg Gln Ala Val Arg Val Ser Pro Cys His Ser Arg Gln Pro Ser
                 405                 410                 415    
 Val Ile Ser Asp Ala Ser Ala Ala Glu Gly Asp Arg Ser Ser Thr Pro
             420                 425                 430        
 Ser Asp Ile Asn Ser Pro Arg His Arg Thr His Ser Leu Cys Asn Val
         435                 440                 445            
 Arg Pro Ala Ala Ala Gly Pro Gly Pro Leu Gly Pro Ala Gln Lys Leu
     450                 455                 460                
 Gln Gly Arg Gly Trp Arg Gly Glu Ala Ile Leu Ala Val Ser Ser Arg
 465                 470                 475                 480
 Pro Pro Arg Glu His Ser Gly Glu Cys Ile Ser Cys Ser Val Leu Ser
                 485                 490                 495    
 Phe Cys Lys Lys Arg Trp Met Trp Gly Glu Lys Gly Met Arg Pro Val
             500                 505                 510        
 Cys Ser Leu Cys Pro Gly Gly
         515                



      <210> 2522
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 2522
 Met Leu Cys Ser Arg Leu Gly Thr Thr Ala Ser Trp Arg Arg Leu Gly
   1               5                  10                  15    
 Ile Arg Ala Trp Ala Pro Leu Leu Leu Leu Phe Pro Trp Asp Trp His
              20                  25                  30        
 Phe Ile Leu Ser Phe Ser Ser Arg Pro Trp Ala Gly Thr Leu Leu Ala
          35                  40                  45            
 Pro His Asp Val Ile Met Gly Ser Ser Thr Phe Pro Gln Ser Cys Gln
      50                  55                  60                
 Ala Glu Ala Gly Pro Arg His Ala Trp Pro Thr Gly Arg Phe Ser Arg
  65                  70                  75                  80
 Arg Leu Arg Arg Val
                  85



      <210> 2523
      <211> 143
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(143)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2523
 Asn Thr Leu Leu Thr Ile Ile Val Leu Phe Pro Asp Pro Pro Ser Leu
   1               5                  10                  15    
 Ser Ser Asn Ser Ser Ile Arg Ser Ser Ser Ser Phe Ser Thr Cys Ile
              20                  25                  30        
 Ser Cys Glu Leu Ser Thr Ser Gly Cys Pro Ala Ile Thr Thr Glu Ser
          35                  40                  45            
 Val Ser Ala Ser Pro Ser Met Ile Ser Pro Ser Ala Thr Ser Val Xaa
      50                  55                  60                
 Val Thr Ser Xaa Ser Ser Ser Cys Thr Ser Ala Ser Pro Gly Ser Pro
  65                  70                  75                  80
 Gly Ser Cys Trp Leu Leu Leu Glu Ser Xaa Glu Ala Pro Trp Ala Ser
                  85                  90                  95    
 Cys Ser Asp Leu Phe Leu Leu Glu Ala Leu Leu Leu Pro Lys Arg Leu
             100                 105                 110        
 Leu Gly Trp Phe Thr Ile Arg Glu Ser Val Ser Lys Gly Phe Arg Ala
         115                 120                 125            
 Ala Leu Thr Val Leu Ala Met Leu Gly Leu Asp Arg Ser Lys Leu
     130                 135                 140            



      <210> 2524
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 2524
 Met Phe Val Ile Ala Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala
   1               5                  10                  15    
 Lys Phe Leu Lys Lys Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu
              20                  25                  30        
 Ala Ala Ser Leu Ala Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile
          35                  40                  45            
 Lys Leu Ile Val Gly Arg Pro Arg Pro Asp Phe Phe Tyr Arg Cys Phe
      50                  55                  60                
 Pro Asp Gly Leu Ala His Ser Asp Leu Met Cys Thr Gly Asp Lys Asp
  65                  70                  75                  80
 Val Val Asn Glu Gly Arg Lys Ser Phe Pro Ser Gly His Ser Ser Phe
                  85                  90                  95    
 Ala Phe Ala Gly Leu Ala Phe Ala Ser Phe Tyr Leu Ala Gly Lys Leu
             100                 105                 110        
 His Cys Phe Thr Pro Gln Gly Arg Gly Lys Ser Trp Arg Phe Cys Ala
         115                 120                 125            
 Phe Leu Ser Pro Leu Leu Phe Ala Ala Val Ile Ala Leu Ser Arg Thr
     130                 135                 140                
 Cys Asp Tyr Lys His His Trp Gln Gly Pro Phe Lys Trp
 145                 150                 155        



      <210> 2525
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 2525
 Met Phe Val Ile Ala Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala
   1               5                  10                  15    
 Lys Phe Leu Lys Lys Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu
              20                  25                  30        
 Ala Ala Ser Leu Ala Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile
          35                  40                  45            
 Lys Leu Ile Val Gly Arg Pro Arg Pro Asp Phe Phe Tyr Arg Cys Phe
      50                  55                  60                
 Pro Asp Gly Leu Ala His Ser Asp Leu Met Cys Thr Gly Asp Lys Asp
  65                  70                  75                  80
 Val Val Asn Glu Gly Arg Lys Ser Phe Pro Ser Gly His Ser Ser Phe
                  85                  90                  95    
 Ala Phe Ala Gly Leu Ala Phe Ala Ser Phe Tyr Leu Ala Gly Lys Leu
             100                 105                 110        
 His Cys Phe Thr Pro Gln Gly Arg Gly Lys Ser Trp Arg Phe Cys Ala
         115                 120                 125            
 Phe Leu Ser Pro Leu Leu Phe Ala Ala Val Ile Ala Leu Ser Arg Thr
     130                 135                 140                
 Cys Asp Tyr Lys His His Trp Gln Gly Pro Phe Lys Trp
 145                 150                 155        



      <210> 2526
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 2526
 Lys Gly Ser Thr Glu Ala Phe Ile Ser Gly Thr Ala Gly Trp Gly Thr
   1               5                  10                  15    
 Gly Leu Leu Pro Ser Ser Ala Gly Leu Pro Gly Gly Trp Gly Pro Ala
              20                  25                  30        
 Gly Gly Trp Ala Gly Thr Asp Arg Arg Gly Pro Arg Ala Arg Pro Ile
          35                  40                  45            
 Pro Gln Lys Ser Pro Pro Trp Pro Trp Ser Gly Asp Ala Ala Lys Gly
      50                  55                  60                
 Gln Ser Gly Phe Leu Pro Val Ala Ala Trp Ala Gly Gln Gly Arg Leu
  65                  70                  75                  80
 Pro Gly Gly Gly Ile Ile Val His
                  85            



      <210> 2527
      <211> 204
      <212> PRT
      <213> Homo sapiens


      <400> 2527
 Pro Arg Val Arg Leu Phe Thr Val Ile Thr Tyr Phe Phe Val Val Ile
   1               5                  10                  15    
 Gly Ile Ala Pro Ile Phe Ile Leu Tyr Glu Leu Asp Ser Pro Leu Cys
              20                  25                  30        
 Trp Asn Glu Val Phe Ile Gly Tyr Gly Ser Ala Leu Gly Ser Ala Ser
          35                  40                  45            
 Phe Leu Thr Ser Phe Leu Gly Ile Trp Leu Phe Ser Tyr Cys Met Glu
      50                  55                  60                
 Asp Ile His Met Ala Phe Ile Gly Ile Phe Thr Thr Met Thr Gly Met
  65                  70                  75                  80
 Ala Met Thr Ala Phe Ala Ser Thr Thr Leu Met Met Phe Leu Ala Arg
                  85                  90                  95    
 Val Pro Phe Leu Phe Thr Ile Val Pro Phe Ser Val Leu Arg Ser Met
             100                 105                 110        
 Leu Ser Lys Val Val Arg Ser Thr Glu Gln Gly Thr Leu Phe Ala Cys
         115                 120                 125            
 Ile Ala Phe Leu Glu Thr Leu Gly Gly Val Thr Ala Val Ser Thr Phe
     130                 135                 140                
 Asn Gly Ile Tyr Ser Ala Thr Val Ala Trp Tyr Pro Gly Phe Thr Phe
 145                 150                 155                 160
 Leu Leu Ser Ala Gly Leu Leu Leu Leu Pro Ala Ile Ser Leu Cys Val
                 165                 170                 175    
 Val Lys Cys Thr Ser Trp Asn Glu Gly Ser Tyr Glu Leu Leu Ile Gln
             180                 185                 190        
 Glu Glu Ser Ser Glu Asp Ala Ser Asp Arg Ala Cys
         195                 200                



      <210> 2528
      <211> 204
      <212> PRT
      <213> Homo sapiens


      <400> 2528
 Pro Arg Val Arg Leu Phe Thr Val Ile Thr Tyr Phe Phe Val Val Ile
   1               5                  10                  15    
 Gly Ile Ala Pro Ile Phe Ile Leu Tyr Glu Leu Asp Ser Pro Leu Cys
              20                  25                  30        
 Trp Asn Glu Val Phe Ile Gly Tyr Gly Ser Ala Leu Gly Ser Ala Ser
          35                  40                  45            
 Phe Leu Thr Ser Phe Leu Gly Ile Trp Leu Phe Ser Tyr Cys Met Glu
      50                  55                  60                
 Asp Ile His Met Ala Phe Ile Gly Ile Phe Thr Thr Met Thr Gly Met
  65                  70                  75                  80
 Ala Met Thr Ala Phe Ala Ser Thr Thr Leu Met Met Phe Leu Ala Arg
                  85                  90                  95    
 Val Pro Phe Leu Phe Thr Ile Val Pro Phe Ser Val Leu Arg Ser Met
             100                 105                 110        
 Leu Ser Lys Val Val Arg Ser Thr Glu Gln Gly Thr Leu Phe Ala Cys
         115                 120                 125            
 Ile Ala Phe Leu Glu Thr Leu Gly Gly Val Thr Ala Val Ser Thr Phe
     130                 135                 140                
 Asn Gly Ile Tyr Ser Ala Thr Val Ala Trp Tyr Pro Gly Phe Thr Phe
 145                 150                 155                 160
 Leu Leu Ser Ala Gly Leu Leu Leu Leu Pro Ala Ile Ser Leu Cys Val
                 165                 170                 175    
 Val Lys Cys Thr Ser Trp Asn Glu Gly Ser Tyr Glu Leu Leu Ile Gln
             180                 185                 190        
 Glu Glu Ser Ser Glu Asp Ala Ser Asp Arg Ala Cys
         195                 200                



      <210> 2529
      <211> 409
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(409)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2529
 Leu Gly Glu Pro Leu Gly Asp Leu Cys Glu Leu Ile Pro Gly Asp Val
   1               5                  10                  15    
 Gln Gln Leu Gln Met Gly Glu Val His Pro Gly Thr Gly Ala Gln Gly
              20                  25                  30        
 Ser Ala Ala Gln Ser Val Ala Gly Glu Val Gln Leu Thr Gln Leu Ser
          35                  40                  45            
 His Ala Arg Gln Arg Pro Ser Cys Gln Gly Ser Gln Leu Ile Ala Leu
      50                  55                  60                
 Asp Leu Gln His Met Asp Ile Ser Arg Gln Pro Arg Trp Gln His Val
  65                  70                  75                  80
 Gln Pro Val Ala Arg Gln Val Gln Arg Ala Gln Gln Ala Gln Leu Ala
                  85                  90                  95    
 Glu Gly Val Ala Val His Leu Trp Ala Gly Asp Ala Val Val Ala Glu
             100                 105                 110        
 Val Glu Leu Leu Gln Glu Val Gly Gly Gly Lys Val Phe Ala Ala Asn
         115                 120                 125            
 Ala Cys Asp Leu Val Val Gln Asp His Glu Gly Ala His Ala Ala Arg
     130                 135                 140                
 Gln Ala Thr Gly His Ala Leu Gln Arg Val Ile Val Gln Val Arg Arg
 145                 150                 155                 160
 Val Gln Pro Leu Glu Ala Leu Xaa Arg Val Pro Ser Gly Leu Pro Arg
                 165                 170                 175    
 Arg Val Arg Ala Phe Met Ile Leu His Asn Gln Ile Thr Gly Ile Gly
             180                 185                 190        
 Arg Glu Asp Phe Ala Thr Thr Tyr Phe Leu Glu Glu Leu Asn Leu Ser
         195                 200                 205            
 Tyr Asn Arg Ile Thr Ser Pro Gln Val His Arg Asp Ala Phe Arg Lys
     210                 215                 220                
 Leu Arg Leu Leu Arg Ser Leu Asp Leu Ser Gly Asn Arg Leu His Met
 225                 230                 235                 240
 Leu Pro Pro Gly Leu Pro Arg Asn Val His Val Leu Lys Val Lys Arg
                 245                 250                 255    
 Asn Glu Leu Ala Ala Leu Ala Arg Gly Ala Leu Ala Gly Met Ala Gln
             260                 265                 270        
 Leu Arg Glu Leu Tyr Leu Thr Ser Asn Arg Leu Arg Ser Arg Ala Leu
         275                 280                 285            
 Gly Pro Arg Ala Trp Val Asp Leu Ala His Leu Gln Leu Leu Asp Ile
     290                 295                 300                
 Ala Gly Asn Gln Leu Thr Glu Ile Pro Glu Gly Leu Pro Glu Ser Leu
 305                 310                 315                 320
 Glu Tyr Leu Tyr Leu Gln Asn Asn Lys Ile Ser Ala Val Pro Ala Asn
                 325                 330                 335    
 Ala Phe Asp Ser Thr Pro Asn Leu Lys Gly Ile Phe Leu Arg Phe Asn
             340                 345                 350        
 Lys Leu Ala Val Gly Ser Val Val Asp Ser Ala Phe Arg Arg Leu Lys
         355                 360                 365            
 His Leu Gln Val Leu Asp Ile Glu Gly Asn Leu Glu Phe Gly Asp Ile
     370                 375                 380                
 Ser Lys Asp Arg Gly Arg Leu Gly Lys Glu Lys Glu Glu Glu Glu Glu
 385                 390                 395                 400
 Asp Glu Val Glu Glu Glu Glu Thr Arg
                 405                



      <210> 2530
      <211> 556
      <212> PRT
      <213> Homo sapiens


      <400> 2530
 Leu Ala Asp Gly Asp Met Leu Pro Leu Leu Leu Leu Pro Leu Leu Trp
   1               5                  10                  15    
 Gly Gly Ser Leu Gln Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys
              20                  25                  30        
 Ser Val Thr Val Gln Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe
          35                  40                  45            
 Ser Tyr Pro Trp Arg Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr
      50                  55                  60                
 Trp Phe Arg Asp Gly Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr
  65                  70                  75                  80
 Asn Asn Pro Asp Arg Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg
                  85                  90                  95    
 Leu Leu Gly Asp Val Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp
             100                 105                 110        
 Ala Arg Met Glu Asp Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly
         115                 120                 125            
 Arg Asp Val Lys Tyr Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val
     130                 135                 140                
 Thr Ala Leu Ile Glu Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu
 145                 150                 155                 160
 Ser Gly Arg Pro Thr Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu
                 165                 170                 175    
 Ala Gly Pro Pro Leu Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro
             180                 185                 190        
 Leu Asp Pro Glu Thr Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg
         195                 200                 205            
 Pro Glu Asp His Gly Thr Asn Leu Thr Cys Gln Met Lys Arg Gln Gly
     210                 215                 220                
 Ala Gln Val Thr Thr Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala
 225                 230                 235                 240
 Pro Gln Thr Ile Thr Ile Phe Arg Asn Gly Ile Ala Leu Glu Ile Leu
                 245                 250                 255    
 Gln Asn Thr Ser Tyr Leu Pro Val Leu Glu Gly Gln Ala Leu Arg Leu
             260                 265                 270        
 Leu Cys Asp Ala Pro Ser Asn Pro Pro Ala His Leu Ser Trp Phe Gln
         275                 280                 285            
 Gly Ser Pro Ala Leu Asn Ala Thr Pro Ile Ser Asn Thr Gly Ile Leu
     290                 295                 300                
 Glu Leu Arg Arg Val Arg Ser Ala Glu Glu Gly Gly Phe Thr Cys Arg
 305                 310                 315                 320
 Ala Gln His Pro Leu Gly Ser Leu Gln Ile Phe Leu Asn Leu Ser Val
                 325                 330                 335    
 Tyr Ser Leu Pro Gln Leu Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu
             340                 345                 350        
 Gly Leu His Cys Arg Cys Ser Phe Arg Ala Arg Pro Ala Pro Ser Leu
         355                 360                 365            
 Cys Trp Arg Leu Glu Glu Lys Pro Leu Glu Gly Asn Ser Ser Gln Gly
     370                 375                 380                
 Ser Phe Lys Val Asn Ser Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser
 385                 390                 395                 400
 Leu Ile Leu His Gly Gly Leu Ser Ser Asp Leu Lys Val Ser Cys Lys
                 405                 410                 415    
 Ala Trp Asn Ile Tyr Gly Ser Gln Ser Gly Ser Val Leu Leu Leu Gln
             420                 425                 430        
 Gly Arg Ser Asn Leu Gly Thr Gly Val Val Pro Ala Ala Leu Gly Gly
         435                 440                 445            
 Ala Gly Val Met Ala Leu Leu Cys Ile Cys Leu Cys Leu Ile Phe Phe
     450                 455                 460                
 Leu Ile Val Lys Ala Arg Arg Lys Gln Ala Ala Gly Arg Pro Glu Lys
 465                 470                 475                 480
 Met Asp Asp Glu Asp Pro Ile Met Gly Thr Ile Thr Ser Gly Ser Arg
                 485                 490                 495    
 Lys Lys Pro Trp Pro Asp Ser Pro Gly Asp Gln Ala Ser Pro Pro Gly
             500                 505                 510        
 Asp Ala Pro Pro Leu Glu Glu Gln Lys Glu Leu His Tyr Ala Ser Leu
         515                 520                 525            
 Ser Phe Ser Glu Met Lys Ser Arg Glu Pro Lys Asp Gln Glu Ala Pro
     530                 535                 540                
 Ser Thr Thr Glu Tyr Ser Glu Ile Lys Thr Ser Lys
 545                 550                 555    



      <210> 2531
      <211> 556
      <212> PRT
      <213> Homo sapiens


      <400> 2531
 Leu Ala Asp Gly Asp Met Leu Pro Leu Leu Leu Leu Pro Leu Leu Trp
   1               5                  10                  15    
 Gly Gly Ser Leu Gln Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys
              20                  25                  30        
 Ser Val Thr Val Gln Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe
          35                  40                  45            
 Ser Tyr Pro Trp Arg Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr
      50                  55                  60                
 Trp Phe Arg Asp Gly Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr
  65                  70                  75                  80
 Asn Asn Pro Asp Arg Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg
                  85                  90                  95    
 Leu Leu Gly Asp Val Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp
             100                 105                 110        
 Ala Arg Met Glu Asp Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly
         115                 120                 125            
 Arg Asp Val Lys Tyr Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val
     130                 135                 140                
 Thr Ala Leu Ile Glu Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu
 145                 150                 155                 160
 Ser Gly Arg Pro Thr Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu
                 165                 170                 175    
 Ala Gly Pro Pro Leu Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro
             180                 185                 190        
 Leu Asp Pro Glu Thr Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg
         195                 200                 205            
 Pro Glu Asp His Gly Thr Asn Leu Thr Cys Gln Met Lys Arg Gln Gly
     210                 215                 220                
 Ala Gln Val Thr Thr Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala
 225                 230                 235                 240
 Pro Gln Thr Ile Thr Ile Phe Arg Asn Gly Ile Ala Leu Glu Ile Leu
                 245                 250                 255    
 Gln Asn Thr Ser Tyr Leu Pro Val Leu Glu Gly Gln Ala Leu Arg Leu
             260                 265                 270        
 Leu Cys Asp Ala Pro Ser Asn Pro Pro Ala His Leu Ser Trp Phe Gln
         275                 280                 285            
 Gly Ser Pro Ala Leu Asn Ala Thr Pro Ile Ser Asn Thr Gly Ile Leu
     290                 295                 300                
 Glu Leu Arg Arg Val Arg Ser Ala Glu Glu Gly Gly Phe Thr Cys Arg
 305                 310                 315                 320
 Ala Gln His Pro Leu Gly Ser Leu Gln Ile Phe Leu Asn Leu Ser Val
                 325                 330                 335    
 Tyr Ser Leu Pro Gln Leu Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu
             340                 345                 350        
 Gly Leu His Cys Arg Cys Ser Phe Arg Ala Arg Pro Ala Pro Ser Leu
         355                 360                 365            
 Cys Trp Arg Leu Glu Glu Lys Pro Leu Glu Gly Asn Ser Ser Gln Gly
     370                 375                 380                
 Ser Phe Lys Val Asn Ser Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser
 385                 390                 395                 400
 Leu Ile Leu His Gly Gly Leu Ser Ser Asp Leu Lys Val Ser Cys Lys
                 405                 410                 415    
 Ala Trp Asn Ile Tyr Gly Ser Gln Ser Gly Ser Val Leu Leu Leu Gln
             420                 425                 430        
 Gly Arg Ser Asn Leu Gly Thr Gly Val Val Pro Ala Ala Leu Gly Gly
         435                 440                 445            
 Ala Gly Val Met Ala Leu Leu Cys Ile Cys Leu Cys Leu Ile Phe Phe
     450                 455                 460                
 Leu Ile Val Lys Ala Arg Arg Lys Gln Ala Ala Gly Arg Pro Glu Lys
 465                 470                 475                 480
 Met Asp Asp Glu Asp Pro Ile Met Gly Thr Ile Thr Ser Gly Ser Arg
                 485                 490                 495    
 Lys Lys Pro Trp Pro Asp Ser Pro Gly Asp Gln Ala Ser Pro Pro Gly
             500                 505                 510        
 Asp Ala Pro Pro Leu Glu Glu Gln Lys Glu Leu His Tyr Ala Ser Leu
         515                 520                 525            
 Ser Phe Ser Glu Met Lys Ser Arg Glu Pro Lys Asp Gln Glu Ala Pro
     530                 535                 540                
 Ser Thr Thr Glu Tyr Ser Glu Ile Lys Thr Ser Lys
 545                 550                 555    



      <210> 2532
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 2532
 Gln Gln Ala Glu Glu His Leu Ala Ala Tyr Ser Val Ser Asp Ser Asp
   1               5                  10                  15    
 Ser Gly Lys Asp Pro Ser Met Glu Cys Cys Arg Arg Ala Thr Pro Gly
              20                  25                  30        
 Thr Leu Leu Leu Phe Leu Ala Phe Leu Leu Leu Ser Ser Arg Thr Ala
          35                  40                  45            
 Arg Ser Glu Glu Asp Arg Asp Gly Leu Trp Asp Ala Trp Gly Pro Trp
      50                  55                  60                
 Ser Glu Cys Ser Arg Thr Cys Gly Gly Gly Ala Ser Tyr Ser Leu Arg
  65                  70                  75                  80
 Arg Cys Leu Ser Ser Lys Ser Cys Glu Gly Arg Asn Ile Arg Tyr Arg
                  85                  90                  95    
 Thr Cys Ser Asn Val Asp Cys Pro Pro Glu Ala Gly Asp Phe Arg Ala
             100                 105                 110        
 Gln Gln Cys Ser Ala His Asn Asp Val Lys His His Gly Gln Phe Tyr
         115                 120                 125            
 Glu Trp Leu Pro Val Ser Asn Asp Pro Asp Asn Pro Cys Ser Leu Lys
     130                 135                 140                
 Cys Gln Ala Lys Gly Thr Thr Leu Val Val Glu Leu Ala Pro Lys Val
 145                 150                 155                 160
 Leu Asp Gly Thr Arg Cys Tyr Thr Glu Ser Leu Asp Met Cys Ile Ser
                 165                 170                 175    
 Gly Leu Cys Gln Val Ser Ala Asp Leu Phe Ser Phe Asn Leu Ser Arg
             180                 185                 190        
 Gly Phe Gln Cys Leu Cys Val Asn Gly Leu His Ser Leu Thr Leu
         195                 200                 205        



      <210> 2533
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 2533
 Gly Gln Pro Ala Arg Val Trp Ser Leu Asp Thr Met Gly Thr Arg Leu
   1               5                  10                  15    
 Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu Gly Phe Glu Val Gln
              20                  25                  30        
 Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro Ser Pro Thr Phe Leu
          35                  40                  45            
 Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp Glu Ser Ala Lys Thr
      50                  55                  60                
 Ala Ala Gln Asn Leu Tyr Glu Lys Thr Tyr Leu Pro Ala Val Asp Glu
  65                  70                  75                  80
 Lys Leu Arg Asp Leu Tyr Ser Lys Ser Thr Ala Ala Met Ser Thr Tyr
                  85                  90                  95    
 Thr Gly Ile Phe Thr Asp Gln Val Leu Ser Val Leu Lys Gly Glu Glu
             100                 105                 110        





      <210> 2534
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 2534
 Gly Gln Pro Ala Arg Val Trp Ser Leu Asp Thr Met Gly Thr Arg Leu
   1               5                  10                  15    
 Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu Gly Phe Glu Val Gln
              20                  25                  30        
 Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro Ser Pro Thr Phe Leu
          35                  40                  45            
 Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp Glu Ser Ala Lys Thr
      50                  55                  60                
 Ala Ala Gln Asn Leu Tyr Glu Lys Thr Tyr Leu Pro Ala Val Asp Glu
  65                  70                  75                  80
 Lys Leu Arg Asp Leu Tyr Ser Lys Ser Thr Ala Ala Met Ser Thr Tyr
                  85                  90                  95    
 Thr Gly Ile Phe Thr Asp Gln Val Leu Ser Val Leu Lys Gly Glu Glu
             100                 105                 110        





      <210> 2535
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 2535
 Met Trp Arg Lys His Leu Ser Leu Leu Val Leu Arg Asp Phe Leu Leu
   1               5                  10                  15    
 Ala Pro Arg Arg Arg Asp Ser Leu Thr Leu Thr His Met Ala Thr Leu
              20                  25                  30        
 Ala Gln Lys Pro Cys Gly Ile Glu Lys Gln Ile Cys Phe Tyr Val Leu
          35                  40                  45            
 Phe Ser Leu Ser Ile Phe Gln His Arg Leu Asn Ser Leu Lys Pro Arg
      50                  55                  60                
 His Leu Leu Arg Pro Asp Pro
  65                  70    



      <210> 2536
      <211> 791
      <212> PRT
      <213> Homo sapiens


      <400> 2536
 Met Val Ser Ile Ser Asp Leu Val Ile Cys Pro Pro Arg His Pro Lys
   1               5                  10                  15    
 Val Leu Gly Leu Gln Gly Pro Pro Gly Leu Asp Ser Ile Ser Asp Pro
              20                  25                  30        
 Ser Ala Gly Ala Gly Phe Leu Asp Trp Gly Glu Ile Gly Met Pro Gly
          35                  40                  45            
 Pro Gly Arg Ala Gly His Gln Ala Leu Cys Lys Cys Asp Cys Gln Cys
      50                  55                  60                
 Leu Glu Lys Thr Thr Thr Lys Ala Pro Gly Lys Met Pro Lys Ser Thr
  65                  70                  75                  80
 Arg Ser Gly Pro Val Arg Val Arg Leu Ala Asp Gly Pro Asn Arg Cys
                  85                  90                  95    
 Ala Gly Arg Leu Glu Cys Gly Met Pro Asp Ala Gly Glu Gln Cys Val
             100                 105                 110        
 Met Thr Thr Gly Thr Ser Gly Arg His Cys Gly Leu Leu Gly Thr Gly
         115                 120                 125            
 Leu Trp Lys Gly Tyr Thr Asp Leu Thr Ile Ile Pro Pro Gly Pro Gly
     130                 135                 140                
 Thr Pro Pro Gln Glu Arg Thr Cys Gln Gly Asp Tyr His Ser Gly Gly
 145                 150                 155                 160
 Thr Trp Thr His Ser Pro Leu Glu Thr Thr Arg Arg Pro Gly Ser Ser
                 165                 170                 175    
 Ser Pro Ala Ile Arg Arg Leu Pro Ala Gln Met Leu Leu Leu Pro Ala
             180                 185                 190        
 Arg Pro Pro His Pro Arg Ser Ser Ser Pro Glu Ala Met Asp Pro Pro
         195                 200                 205            
 Pro Pro Lys Ala Pro Pro Phe Pro Lys Ala Glu Gly Pro Ser Ser Thr
     210                 215                 220                
 Pro Ser Ser Ala Ala Gly Pro Arg Pro Pro Arg Leu Gly Arg His Leu
 225                 230                 235                 240
 Leu Ile Asp Ala Asn Gly Val Tyr Pro Tyr Thr Tyr Thr Val Gln Leu
                 245                 250                 255    
 Glu Glu Glu Pro Arg Gly Pro Pro Gln Arg Glu Ala Pro Pro Gly Glu
             260                 265                 270        
 Pro Gly Pro Arg Lys Gly Tyr Ser Cys Pro Glu Cys Ala Arg Val Phe
         275                 280                 285            
 Ala Ser Pro Leu Arg Leu Gln Ser His Arg Val Ser His Ser Asp Leu
     290                 295                 300                
 Lys Pro Phe Thr Cys Gly Ala Cys Gly Lys Ala Phe Lys Arg Ser Ser
 305                 310                 315                 320
 His Leu Ser Arg His Arg Ala Thr His Arg Ala Arg Ala Gly Pro Pro
                 325                 330                 335    
 His Thr Cys Pro Leu Cys Pro Arg Arg Phe Gln Asp Ala Ala Glu Leu
             340                 345                 350        
 Ala Gln His Ser Trp Gly Thr Pro Arg Gly Pro Leu Leu Ala Ala Ala
         355                 360                 365            
 Cys Asn Cys Glu Val Ala Arg Gly Arg Leu Glu Ser Pro Gly Pro Glu
     370                 375                 380                
 Arg Leu Leu His Gly Tyr Gly Gly Arg Glu Glu Glu Gly Gly Trp Gly
 385                 390                 395                 400
 Arg Ala Ala Gly Gly Leu Asp Arg Val Glu Gly Phe Ile Ser Ser Lys
                 405                 410                 415    
 Ala His His Tyr Leu Leu Ile Asp Thr Gln Gly Val Pro Tyr Thr Val
             420                 425                 430        
 Leu Val Thr Arg Ser His Arg Gly Ser Gln Gly Pro Val Gly Leu Gln
         435                 440                 445            
 Ala Arg Lys Val Leu Gln Leu Pro Arg Val Leu Lys Gly Leu Arg Val
     450                 455                 460                
 His Val His Leu Gln Arg His Ser Ile Thr His Ser Glu Val Pro Gln
 465                 470                 475                 480
 Asp Phe Ala Gly Ser Leu Asp Ser Phe Gln Thr Pro Gly Glu Ser Leu
                 485                 490                 495    
 Arg Leu Val Phe Arg Ala Leu Asp Thr Thr Gln Ser Ser Arg Ile Ser
             500                 505                 510        
 Lys Ala Glu Pro Cys Leu Lys Glu Glu Pro Leu Ser Leu Gly Asp Leu
         515                 520                 525            
 Pro Tyr Met His Thr Thr Leu Cys Phe Cys Arg Lys Arg Arg Ala Ser
     530                 535                 540                
 Pro Gly Pro Gly Thr Leu Gln Arg Gly Ala Leu Ala Trp Pro Asp Trp
 545                 550                 555                 560
 Ala Ser Pro Arg Ala Leu Pro Val Pro Ser Leu Ser Ser Thr Thr Arg
                 565                 570                 575    
 Ser Pro Ala Ala Pro Leu Phe Ala Val Pro Leu Ser Gly Arg Thr Thr
             580                 585                 590        
 Gln Ala Met Ala Phe Asp Gly Ile Ile Phe Gln Gly Gln Ser Gln Arg
         595                 600                 605            
 Ser Ala Gly Leu Thr Thr Thr Ser Arg Phe Leu Ala Cys Gln Arg Pro
     610                 615                 620                
 Leu Arg Leu Cys Ala Trp Trp Ala Ser Arg Ser Pro Arg Cys Thr Leu
 625                 630                 635                 640
 Arg Arg Pro Val Gly Leu Arg Pro Gly Val His Pro Arg Pro Arg Leu
                 645                 650                 655    
 Val Tyr Arg Asp Leu Lys Pro Glu Asn Val Met Ala Ser Gly Gln Pro
             660                 665                 670        
 Arg Asp Arg Pro Gln Pro Trp Phe Ala Trp Pro Pro Arg Pro Thr Arg
         675                 680                 685            
 Phe Cys Gly Gly Cys Trp Thr Leu Thr Pro Lys Glu Glu Arg Cys Asp
     690                 695                 700                
 Arg His Gln Gly Ala Pro Gly Ala Pro Trp Arg Gln Arg Glu Gly Glu
 705                 710                 715                 720
 Ala Glu Ala Val Gly Ala Val Glu Glu Arg Leu Gly Ser Glu Glu Ala
                 725                 730                 735    
 Pro Gly Asp Ala Glu Arg Glu Ala Ala His Pro Arg Pro Pro Arg Pro
             740                 745                 750        
 Thr Ala Phe Gly Val Ser Ser Gly Leu Pro Glu Leu Leu Val Lys Arg
         755                 760                 765            
 Val Val Ala Gln Leu Gln Glu Leu Trp Thr Ser Ser Thr Ala Gly Gly
     770                 775                 780                
 Trp Ser Thr Gln Met Gln Thr
 785                 790    



      <210> 2537
      <211> 239
      <212> PRT
      <213> Homo sapiens


      <400> 2537
 Met Arg Ser Ser Leu Thr Met Val Gly Thr Leu Trp Ala Phe Leu Ser
   1               5                  10                  15    
 Leu Val Thr Ala Val Thr Ser Ser Thr Ser Tyr Phe Leu Pro Tyr Trp
              20                  25                  30        
 Leu Phe Gly Ser Gln Met Gly Lys Pro Val Ser Phe Ser Thr Phe Arg
          35                  40                  45            
 Arg Cys Asn Tyr Pro Val Arg Gly Glu Gly His Ser Leu Ile Met Val
      50                  55                  60                
 Glu Glu Cys Gly Arg Tyr Ala Ser Phe Asn Ala Ile Pro Ser Leu Ala
  65                  70                  75                  80
 Trp Gln Met Cys Thr Val Val Thr Gly Ala Gly Cys Ala Leu Leu Leu
                  85                  90                  95    
 Leu Val Ala Leu Ala Ala Val Leu Gly Cys Cys Met Glu Glu Leu Ile
             100                 105                 110        
 Ser Arg Met Met Gly Arg Cys Met Gly Ala Ala Gln Phe Val Gly Gly
         115                 120                 125            
 Leu Leu Ile Ser Ser Gly Cys Ala Leu Tyr Pro Leu Gly Trp Asn Ser
     130                 135                 140                
 Pro Glu Ile Met Gln Thr Cys Gly Asn Val Ser Asn Gln Phe Gln Leu
 145                 150                 155                 160
 Gly Thr Cys Arg Leu Gly Trp Ala Tyr Tyr Cys Ala Gly Gly Gly Ala
                 165                 170                 175    
 Ala Ala Ala Met Leu Ile Cys Thr Trp Leu Ser Cys Phe Ala Gly Arg
             180                 185                 190        
 Asn Pro Lys Pro Val Ile Leu Gly Gly Lys His His Glu Glu Asn His
         195                 200                 205            
 Phe Leu Cys Tyr Gly Ala Trp Pro Leu Pro Ser Thr Leu Glu Leu Arg
     210                 215                 220                
 Lys Glu Asp Arg Gly Gly Arg Ala Thr Gly Lys Gln Val Thr Pro
 225                 230                 235                



      <210> 2538
      <211> 487
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(487)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2538
 Met Ala Ala Ala Ala Ala Gly Ala Gly Ser Gly Pro Trp Ala Ala Gln
   1               5                  10                  15    
 Glu Lys Gln Phe Pro Pro Ala Leu Leu Ser Phe Phe Ile Tyr Asn Pro
              20                  25                  30        
 Arg Phe Gly Pro Arg Glu Gly Gln Glu Glu Asn Lys Ile Leu Phe Tyr
          35                  40                  45            
 His Pro Asn Glu Val Glu Lys Asn Glu Lys Ile Arg Asn Val Gly Leu
      50                  55                  60                
 Cys Glu Ala Ile Val Gln Phe Thr Arg Thr Phe Ser Pro Ser Lys Pro
  65                  70                  75                  80
 Ala Lys Ser Leu His Thr Gln Lys Asn Arg Gln Phe Phe Asn Glu Pro
                  85                  90                  95    
 Glu Glu Asn Phe Trp Met Val Met Val Val Arg Asn Pro Ile Ile Glu
             100                 105                 110        
 Lys Gln Ser Lys Asp Gly Lys Pro Val Ile Glu Tyr Gln Glu Glu Glu
         115                 120                 125            
 Leu Leu Asp Lys Val Tyr Ser Ser Val Leu Arg Gln Cys Tyr Ser Met
     130                 135                 140                
 Tyr Lys Leu Phe Asn Gly Thr Phe Leu Lys Ala Met Glu Asp Gly Gly
 145                 150                 155                 160
 Val Lys Leu Leu Lys Glu Arg Leu Glu Lys Phe Phe His Arg Tyr Leu
                 165                 170                 175    
 Gln Thr Leu His Leu Gln Ser Cys Asp Leu Leu Asp Ile Phe Gly Gly
             180                 185                 190        
 Ile Ser Phe Phe Pro Leu Asp Lys Met Thr Tyr Leu Lys Ile Gln Ser
         195                 200                 205            
 Phe Ile Asn Arg Met Glu Glu Ser Leu Asn Ile Val Lys Tyr Thr Ala
     210                 215                 220                
 Phe Leu Tyr Asn Asp Gln Leu Ile Trp Ser Gly Leu Glu Gln Asp Asp
 225                 230                 235                 240
 Met Arg Ile Leu Tyr Lys Tyr Leu Thr Thr Ser Leu Phe Pro Arg His
                 245                 250                 255    
 Ile Glu Pro Glu Leu Ala Gly Arg Asp Ser Pro Ile Arg Ala Glu Met
             260                 265                 270        
 Pro Gly Asn Leu Gln His Tyr Gly Arg Phe Leu Thr Gly Pro Leu Asn
         275                 280                 285            
 Leu Asn Asp Pro Asp Ala Lys Cys Arg Phe Pro Lys Ile Phe Val Asn
     290                 295                 300                
 Thr Asp Asp Thr Tyr Glu Glu Leu His Leu Ile Val Tyr Lys Ala Met
 305                 310                 315                 320
 Ser Ala Ala Val Cys Phe Met Ile Asp Ala Ser Val His Pro Thr Leu
                 325                 330                 335    
 Gly Phe Cys Arg Arg Thr Gly Thr Ala Ser Leu Gly Pro Gln Leu His
             340                 345                 350        
 Ser Gly Trp Ala Ser Gly His Leu Val Glu Gln Phe Xaa His Gln Gln
         355                 360                 365            
 Gly Gly Cys Ser Gly Val Xaa Gly Lys Glu Pro Gln Phe Lys Phe Ile
     370                 375                 380                
 Tyr Phe Asn His Met Asn Leu Ala Glu Lys Ser Thr Val His Met Arg
 385                 390                 395                 400
 Lys Thr Pro Ser Val Ser Leu Thr Ser Val His Pro Asp Leu Met Lys
                 405                 410                 415    
 Ile Leu Gly Asp Ile Asn Ser Asp Phe Thr Arg Val Asp Glu Asp Glu
             420                 425                 430        
 Glu Ile Ile Val Lys Ala Met Ser Asp Tyr Trp Val Val Gly Lys Lys
         435                 440                 445            
 Ser Asp Arg Arg Glu Leu Tyr Val Ile Leu Asn Gln Lys Asn Ala Asn
     450                 455                 460                
 Leu Ile Glu Val Asn Glu Glu Val Lys Lys Leu Cys Ala Thr Gln Phe
 465                 470                 475                 480
 Asn Asn Ile Phe Phe Leu Asp
                 485        



      <210> 2539
      <211> 58
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(58)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2539
 Asn Tyr Ser Leu Ser Val Tyr Leu Val Arg Gln Leu Thr Ala Gly Thr
   1               5                  10                  15    
 Leu Leu Gln Lys Leu Arg Ala Lys Gly Ile Arg Asn Pro Asp His Ser
              20                  25                  30        
 Arg Ala Leu Ser Glu Xaa His Leu Ser Ser Leu Pro His Leu Ile Trp
          35                  40                  45            
 Ile Gln Val Phe Leu Ala Leu Gln Pro Ser
      50                  55            



      <210> 2540
      <211> 193
      <212> PRT
      <213> Homo sapiens


      <400> 2540
 Phe Pro Gly Arg Arg Phe Arg His Asn Ala Arg Arg Gly Phe Phe Phe
   1               5                  10                  15    
 Ser His Ile Gly Trp Leu Phe Val Arg Lys His Arg Asp Val Ile Glu
              20                  25                  30        
 Lys Gly Arg Lys Leu Asp Val Thr Asp Leu Leu Ala Asp Pro Val Val
          35                  40                  45            
 Arg Ile Gln Arg Lys Tyr Tyr Lys Ile Ser Val Val Leu Met Cys Phe
      50                  55                  60                
 Val Val Pro Thr Leu Val Pro Trp Tyr Ile Trp Gly Glu Ser Leu Trp
  65                  70                  75                  80
 Asn Ser Tyr Phe Leu Ala Ser Ile Leu Arg Tyr Thr Ile Ser Leu Asn
                  85                  90                  95    
 Ile Ser Trp Leu Val Asn Ser Ala Ala His Met Tyr Gly Asn Arg Pro
             100                 105                 110        
 Tyr Asp Lys His Ile Ser Pro Arg Gln Asn Pro Leu Val Ala Leu Gly
         115                 120                 125            
 Ala Ile Gly Glu Gly Phe His Asn Tyr His His Thr Phe Pro Phe Asp
     130                 135                 140                
 Tyr Ser Ala Ser Glu Phe Gly Leu Asn Phe Asn Pro Thr Thr Trp Phe
 145                 150                 155                 160
 Ile Asp Phe Met Cys Trp Leu Gly Leu Ala Thr Asp Arg Lys Arg Ala
                 165                 170                 175    
 Thr Lys Pro Met Ile Glu Ala Arg Lys Ala Arg Thr Gly Asp Ser Ser
             180                 185                 190        
 Ala
    



      <210> 2541
      <211> 597
      <212> PRT
      <213> Homo sapiens


      <400> 2541
 Met Thr Ser Gly Pro Gln Thr Ser Gln Pro Lys Glu His Leu Thr Asn
   1               5                  10                  15    
 Phe Lys Ser Asp Glu Gln Glu Arg Val Ser Ser Leu Ala Gln Ser His
              20                  25                  30        
 Thr Asp Asn His Arg Leu His Glu Pro Gly Leu Gln Glu Gly Ile Arg
          35                  40                  45            
 Ala Val Pro Arg Glu Asp Pro Gln Trp Asn Tyr Gln Ala Asp Ser Pro
      50                  55                  60                
 Arg Gly Pro Leu Asp His His Arg Arg Arg Ala Ser Gly Asn Ser Gln
  65                  70                  75                  80
 Trp Arg Gln Ala Lys Leu Ile Ala Leu Thr Arg Ala Leu Thr Leu Ala
                  85                  90                  95    
 Lys Gly Leu Arg Ile Asn Ile Tyr Thr Asp Ser Lys Tyr Ala Phe Arg
             100                 105                 110        
 Ile Leu His His His Ala Val Ile Trp Ala Glu Arg Gly Phe Leu Pro
         115                 120                 125            
 Thr Gln Gly Ser Ser Ile Ile Asn Ala Thr Leu Ile Lys Thr Leu Leu
     130                 135                 140                
 Lys Ala Ala Leu Leu Pro Lys Glu Ala Gly Val Ile His Cys Lys Gly
 145                 150                 155                 160
 His Gln Lys Ala Ser Asp Pro Ile Thr Gln Gly Asn Ala Tyr Ala Asp
                 165                 170                 175    
 Lys Pro Ile Gly Phe Gly Leu Glu Lys Leu Leu Thr Phe His Leu Ser
             180                 185                 190        
 Gln Leu Gln Glu Tyr Arg Gly Thr Lys Trp Arg Glu Lys Ser His Arg
         195                 200                 205            
 Lys Val Asn His Asp Glu Asn Thr Ser Lys Leu Thr Ser Leu Asn Glu
     210                 215                 220                
 Glu Tyr Thr Lys Asn Lys Thr Glu Tyr Glu Glu Ala Gln Asp Ala Ile
 225                 230                 235                 240
 Val Lys Glu Ile Val Asn Ile Ser Ser Gly Tyr Val Glu Pro Met Gln
                 245                 250                 255    
 Thr Leu Asn Asp Val Leu Ala Gln Leu Asp Ala Val Val Ser Phe Ala
             260                 265                 270        
 His Val Ser Asn Gly Ala Pro Val Pro Tyr Val Arg Pro Ala Ile Leu
         275                 280                 285            
 Glu Lys Gly Gln Gly Arg Ile Ile Leu Lys Ala Ser Arg His Ala Cys
     290                 295                 300                
 Val Glu Val Gln Asp Glu Ile Ala Phe Ile Pro Asn Asp Val Tyr Phe
 305                 310                 315                 320
 Glu Lys Asp Lys Gln Met Phe His Ile Ile Thr Gly Pro Asn Met Gly
                 325                 330                 335    
 Gly Lys Ser Thr Tyr Ile Arg Gln Thr Gly Val Ile Val Leu Met Ala
             340                 345                 350        
 Gln Ile Gly Cys Phe Val Pro Cys Glu Ser Ala Glu Val Ser Ile Val
         355                 360                 365            
 Asp Cys Ile Leu Ala Arg Val Gly Ala Gly Asp Ser Gln Leu Lys Gly
     370                 375                 380                
 Val Ser Thr Phe Met Ala Glu Met Leu Glu Thr Ala Ser Ile Leu Arg
 385                 390                 395                 400
 Ser Ala Thr Lys Asp Ser Leu Ile Ile Ile Asp Glu Leu Gly Arg Gly
                 405                 410                 415    
 Thr Ser Thr Tyr Asp Gly Phe Gly Leu Ala Trp Ala Ile Ser Glu Tyr
             420                 425                 430        
 Ile Ala Thr Lys Ile Gly Ala Phe Cys Met Phe Ala Thr His Phe His
         435                 440                 445            
 Glu Leu Thr Ala Leu Ala Asn Gln Ile Pro Thr Val Asn Asn Leu His
     450                 455                 460                
 Val Thr Ala Leu Thr Thr Glu Glu Thr Leu Thr Met Leu Tyr Gln Val
 465                 470                 475                 480
 Lys Lys Gly Val Cys Asp Gln Ser Phe Gly Ile His Val Ala Glu Leu
                 485                 490                 495    
 Ala Asn Phe Pro Lys His Val Ile Glu Cys Ala Lys Gln Lys Ala Leu
             500                 505                 510        
 Glu Leu Glu Glu Phe Gln Tyr Ile Gly Glu Ser Gln Gly Tyr Asp Ile
         515                 520                 525            
 Met Glu Pro Ala Ala Lys Lys Cys Tyr Leu Glu Arg Glu Gln Gly Glu
     530                 535                 540                
 Lys Ile Ile Gln Glu Phe Leu Ser Lys Val Lys Gln Met Pro Phe Thr
 545                 550                 555                 560
 Glu Met Ser Glu Glu Asn Ile Thr Ile Lys Leu Lys Gln Leu Lys Ala
                 565                 570                 575    
 Glu Val Ile Ala Lys Asn Asn Ser Phe Val Asn Glu Ile Ile Ser Arg
             580                 585                 590        
 Ile Lys Val Thr Thr
         595        



      <210> 2542
      <211> 213
      <212> PRT
      <213> Homo sapiens


      <400> 2542
 Ala Gly Thr Ala Arg Phe Val Cys Gln Ala Glu Gly Ile Pro Ser Pro
   1               5                  10                  15    
 Lys Met Ser Trp Leu Lys Asn Gly Arg Lys Ile His Ser Asn Gly Arg
              20                  25                  30        
 Ile Lys Met Tyr Asn Ser Lys Leu Val Ile Asn Gln Ile Ile Pro Glu
          35                  40                  45            
 Asp Asp Ala Ile Tyr Gln Cys Met Ala Glu Asn Ser Gln Gly Ser Ile
      50                  55                  60                
 Leu Ser Arg Ala Arg Leu Thr Val Val Met Ser Glu Asp Arg Pro Ser
  65                  70                  75                  80
 Ala Pro Tyr Asn Val His Ala Glu Thr Met Ser Ser Ser Ala Ile Leu
                  85                  90                  95    
 Leu Ala Trp Glu Arg Pro Leu Tyr Asn Ser Asp Lys Val Ile Ala Tyr
             100                 105                 110        
 Ser Val His Tyr Met Lys Ala Glu Gly Leu Asn Asn Glu Glu Tyr Gln
         115                 120                 125            
 Val Val Ile Gly Asn Asp Thr Thr His Tyr Ile Ile Asp Asp Leu Glu
     130                 135                 140                
 Pro Ala Ser Asn Tyr Thr Phe Tyr Ile Val Ala Tyr Met Pro Met Gly
 145                 150                 155                 160
 Ala Ser Gln Met Ser Asp His Val Thr Gln Asn Thr Leu Glu Asp Gly
                 165                 170                 175    
 His Thr Ser Val Gly Leu Leu Gln Phe Ala Gly Gly Leu Leu Leu Thr
             180                 185                 190        
 Leu Val Ala Ser Val Phe Pro Val Pro Gly Asp Thr Thr Ser Glu Gly
         195                 200                 205            
 Cys Val Thr Ala Lys
     210            



      <210> 2543
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 2543
 Val Pro Arg Leu Val Ser Pro Leu Ser Asn Pro Ala Pro Lys Phe Tyr
   1               5                  10                  15    
 Cys Val Ser Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu
              20                  25                  30        
 Asn Leu Leu Val Arg Ser Arg Asn Lys Gly Ala Leu Asp Thr His Ala
          35                  40                  45            
 Trp Ser Leu Ser Gly Asn Lys Gly Asn Val Trp Gln Gln Ala His Val
      50                  55                  60                
 Pro Ile Ser Pro Ser Gly Pro Phe Gln Ile Ile Phe Glu Gly Val Arg
  65                  70                  75                  80
 Gly Pro Gly Tyr Leu Gly Asp Ile Ala Ile Asp Asp Val Thr Leu Lys
                  85                  90                  95    
 Lys Gly Glu Cys Pro Arg Lys Gln Thr Asp Pro Asn Lys Val Val Val
             100                 105                 110        
 Met Pro Gly Ser Gly Ala Pro Cys Gln Ser Ser Pro Gln Leu Trp Gly
         115                 120                 125            
 Pro Met Ala Ile Phe Leu Leu Ala Leu Gln Arg
     130                 135                



      <210> 2544
      <211> 223
      <212> PRT
      <213> Homo sapiens


      <400> 2544
 Asn Ser Arg Val Glu Gly Gln Leu Cys Asp Leu Asp Pro Ser Ala His
   1               5                  10                  15    
 Phe Tyr Gly His Cys Gly Glu Gln Leu Glu Cys Arg Leu Asp Thr Gly
              20                  25                  30        
 Gly Asp Leu Ser Arg Gly Glu Val Pro Glu Pro Leu Cys Ala Cys Arg
          35                  40                  45            
 Ser Gln Ser Pro Leu Cys Gly Ser Asp Gly His Thr Tyr Ser Gln Ile
      50                  55                  60                
 Cys Arg Leu Gln Glu Ala Ala Arg Ala Arg Pro Asp Ala Asn Leu Thr
  65                  70                  75                  80
 Val Ala His Pro Gly Pro Cys Glu Ser Gly Pro Gln Ile Val Ser His
                  85                  90                  95    
 Pro Tyr Asp Thr Trp Asn Val Thr Gly Gln Asp Val Ile Phe Gly Cys
             100                 105                 110        
 Glu Val Phe Ala Tyr Pro Met Ala Ser Ile Glu Trp Arg Lys Asp Gly
         115                 120                 125            
 Leu Asp Ile Gln Leu Pro Gly Asp Asp Pro His Ile Ser Val Gln Phe
     130                 135                 140                
 Arg Gly Gly Pro Gln Arg Phe Glu Val Thr Gly Trp Leu Gln Ile Gln
 145                 150                 155                 160
 Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr Arg Cys Leu Ala Arg Asn
                 165                 170                 175    
 Ala Leu Gly Gln Val Glu Ala Pro Ala Ser Leu Thr Val Leu Thr Pro
             180                 185                 190        
 Asp Gln Leu Asn Ser Thr Gly Ile Pro Gln Leu Arg Ser Leu Asn Leu
         195                 200                 205            
 Val Pro Glu Glu Glu Ala Glu Ser Glu Glu Asn Asp Asp Tyr Tyr
     210                 215                 220            



      <210> 2545
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 2545
 Ile Ala Thr Met Glu Thr Lys Asp Gln Lys Lys Gln Arg Lys Lys Asn
   1               5                  10                  15    
 Ser Gly Pro Lys Ala Ala Lys Lys Lys Lys Arg His Leu Gln Asp Leu
              20                  25                  30        
 Gln Leu Gly Asp Glu Glu Asp Ala Trp Lys Arg Asn Pro Lys Ala Phe
          35                  40                  45            
 Ala Phe Gln Ser Ala Val Trp Met Ala Arg Ser Phe His Arg Thr Gln
      50                  55                  60                
 Asp Leu Lys Thr Lys Lys His His Ile Pro Val Val Asp Arg Thr Pro
  65                  70                  75                  80
 Leu Glu Pro Pro Pro Ile Val Val Val Val Met Gly Pro Pro Lys Val
                  85                  90                  95    
 Gly Lys Ser Thr Leu Ile Gln Cys Leu Ile Arg Asn Phe Thr Arg Gln
             100                 105                 110        
 Lys Leu Thr Glu Ile Arg Gly Pro Val Met Ile Val Ser Gly Lys Lys
         115                 120                 125            
 Leu Arg Leu Thr Ile Ile Asp Cys Gly Cys Asp Ile Asn Met Met Ile
     130                 135                 140                
 Asp Leu Ala
 145        



      <210> 2546
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 2546
 Met Gly Trp Val Trp Thr Leu Cys Thr Ala Ser Ala Cys Leu Thr Leu
   1               5                  10                  15    
 Leu Phe Trp Ser Gln Thr Pro Gly Lys Ala Phe Gln Ile Pro Cys Pro
              20                  25                  30        
 Pro Pro His Leu Ser His Trp Cys Leu Ser Pro Met Gln Met Asp Asp
          35                  40                  45            
 Gly Cys Ala Arg Leu Cys Val Leu Trp Thr Ala Trp Met Arg Trp Arg
      50                  55                  60                
 Val Leu Met Cys Ser Cys Arg Val Trp Ala Thr Asp Leu Gly Ile Phe
  65                  70                  75                  80
 Leu Gly Val Ala Leu Gly Asn Glu Pro Leu Glu Met Trp Pro Leu Thr
                  85                  90                  95    
 Gln Asn Glu Glu Cys Thr Val Thr Gly Phe Leu Arg Asp Lys Leu Gln
             100                 105                 110        
 Tyr Arg Ser Arg Leu Gln Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr
         115                 120                 125            
 Lys Ile Arg Val Pro Tyr Glu Gly Val Phe Arg Ile Ala Asn Val Thr
     130                 135                 140                
 Arg Leu Arg Ala Gln Gly Ser Glu Arg Glu Leu Arg Tyr Leu Gly Val
 145                 150                 155                 160
 Leu Val Ser Leu Ser Ala Thr Glu Ser Val His Asp Glu Leu Leu
                 165                 170                 175



      <210> 2547
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 2547
 Arg Arg Phe Val Ser Gln Glu Thr Gly Asn Leu Tyr Ile Ala Lys Val
   1               5                  10                  15    
 Glu Lys Ser Asp Val Gly Asn Tyr Thr Cys Val Val Thr Asn Thr Val
              20                  25                  30        
 Thr Asn His Lys Val Leu Gly Pro Pro Thr Pro Leu Ile Leu Arg Asn
          35                  40                  45            
 Asp Gly Val Met Gly Glu Tyr Glu Pro Lys Ile Glu Val Gln Phe Pro
      50                  55                  60                
 Glu Thr Val Pro Thr Ala Lys Gly Ala Thr Val Lys Leu Glu Cys Phe
  65                  70                  75                  80
 Ala Leu Gly Asn Pro Val Pro Thr Ile Ile Trp Arg Arg Ala Asp Gly
                  85                  90                  95    
 Lys Pro Ile Ala Arg Lys Ala Arg Arg His Lys Ser Arg Val Gly Lys
             100                 105                 110        





      <210> 2548
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 2548
 Glu Phe Gln Glu Ala Ala Lys Leu Tyr His Thr Asn Tyr Val Arg Asn
   1               5                  10                  15    
 Ser Arg Ala Ile Gly Val Leu Trp Ala Ile Phe Thr Ile Cys Phe Ala
              20                  25                  30        
 Ile Val Asn Val Val Cys Phe Ile Gln Pro Tyr Trp Ile Gly Asp Gly
          35                  40                  45            
 Val Asp Thr Pro Gln Ala Gly Tyr Phe Gly Leu Phe His Tyr Cys Ile
      50                  55                  60                
 Gly Asn Gly Phe Ser Arg Glu Leu Thr Cys Arg Gly Ser Phe Thr Asp
  65                  70                  75                  80
 Phe Ser Thr Leu Pro Ser Gly Ala Phe Lys Ala Ala Ser Phe Phe Ile
                  85                  90                  95    
 Gly Leu Ser Met Met Leu Ile Ile Ala Cys Ile Ile Cys Phe Thr Leu
             100                 105                 110        
 Phe Phe Phe Cys Asn Thr Ala Thr Val Tyr Lys Ile Cys Ala Trp Met
         115                 120                 125            
 Gln Leu Thr Ser Ala Ala Cys Leu Val Leu Gly Cys Met Ile Phe Pro
     130                 135                 140                
 Asp Gly Trp Asp Ser Asp Glu Val Asn
 145                 150            



      <210> 2549
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 2549
 Ala Phe Thr Lys His Leu Leu Lys Pro Arg Met Glu Val Lys Asp Cys
   1               5                  10                  15    
 Gly Ala His Asn Leu Glu Lys Gly Leu Thr Ile Phe Phe His Lys Gly
              20                  25                  30        
 Pro Ser Ser Met Tyr Phe Arg Leu Cys Gly Pro His Glu Gly Arg Phe
          35                  40                  45            
 Phe Phe Leu Ile Pro Pro Leu His Leu Leu His Leu Leu Phe Pro Leu
      50                  55                  60                
 His Phe Phe Tyr Asn Phe Arg Asp Glu Glu Leu Ser Cys Thr Val Val
  65                  70                  75                  80
 Glu Leu Lys Tyr Thr Gly Asn Ala Ser Ala Leu Leu Ile Leu Pro Asp
                  85                  90                  95    
 Gln Asp Lys Met Glu Glu Val Glu Ala Met Leu Leu Pro Glu Thr Phe
             100                 105                 110        
 Ala Leu Cys Cys
         115    



      <210> 2550
      <211> 784
      <212> PRT
      <213> Homo sapiens


      <400> 2550
 Ala Ile Met Thr Thr Arg Gln Ala Thr Lys Asp Pro Leu Leu Arg Gly
   1               5                  10                  15    
 Val Ser Pro Thr Pro Ser Lys Ile Pro Val Arg Ser Gln Lys Arg Thr
              20                  25                  30        
 Pro Phe Pro Thr Val Thr Ser Cys Ala Val Asp Gln Glu Asn Gln Asp
          35                  40                  45            
 Pro Arg Arg Trp Val Gln Lys Pro Pro Leu Asn Ile Gln Arg Pro Leu
      50                  55                  60                
 Val Asp Ser Ala Gly Pro Arg Pro Lys Ala Arg His Gln Ala Glu Thr
  65                  70                  75                  80
 Ser Gln Arg Leu Val Gly Ile Ser Gln Pro Arg Asn Pro Leu Glu Glu
                  85                  90                  95    
 Leu Arg Pro Ser Pro Arg Gly Gln Asn Val Gly Pro Gly Pro Pro Ala
             100                 105                 110        
 Gln Thr Glu Ala Pro Gly Thr Ile Glu Phe Val Ala Asp Pro Ala Ala
         115                 120                 125            
 Leu Ala Thr Ile Leu Ser Gly Glu Gly Val Lys Ser Cys His Leu Gly
     130                 135                 140                
 Arg Gln Pro Ser Leu Ala Lys Arg Val Leu Val Arg Gly Ser Gln Gly
 145                 150                 155                 160
 Gly Thr Thr Gln Arg Val Gln Gly Val Arg Ala Ser Ala Tyr Leu Ala
                 165                 170                 175    
 Pro Arg Thr Pro Thr His Arg Leu Asp Pro Ala Arg Ala Ser Cys Phe
             180                 185                 190        
 Ser Arg Leu Glu Gly Pro Gly Pro Arg Gly Arg Thr Leu Cys Pro Gln
         195                 200                 205            
 Arg Leu Gln Ala Leu Ile Ser Pro Ser Gly Pro Ser Phe His Pro Ser
     210                 215                 220                
 Thr Arg Pro Ser Phe Gln Glu Leu Arg Arg Glu Thr Ala Gly Ser Ser
 225                 230                 235                 240
 Arg Thr Ser Val Ser Gln Ala Ser Gly Leu Leu Leu Glu Thr Pro Val
                 245                 250                 255    
 Gln Pro Ala Phe Ser Leu Pro Lys Gly Glu Arg Glu Val Val Thr His
             260                 265                 270        
 Ser Asp Glu Gly Gly Val Ala Ser Leu Gly Leu Ala Gln Arg Val Pro
         275                 280                 285            
 Leu Arg Glu Asn Arg Glu Met Ser His Thr Arg Asp Ser His Asp Ser
     290                 295                 300                
 His Leu Met Pro Ser Pro Ala Pro Val Ala Gln Pro Leu Pro Gly His
 305                 310                 315                 320
 Val Val Pro Cys Pro Ser Pro Phe Gly Arg Ala Gln Arg Val Pro Ser
                 325                 330                 335    
 Pro Gly Pro Pro Thr Leu Thr Ser Tyr Ser Val Leu Arg Arg Leu Thr
             340                 345                 350        
 Val Gln Pro Lys Thr Arg Phe Thr Pro Met Pro Ser Thr Pro Arg Val
         355                 360                 365            
 Gln Gln Ala Gln Trp Leu Arg Gly Val Ser Pro Gln Ser Cys Ser Glu
     370                 375                 380                
 Asp Pro Ala Leu Pro Trp Glu Gln Val Ala Val Arg Leu Phe Asp Gln
 385                 390                 395                 400
 Glu Ser Cys Ile Arg Ser Leu Glu Gly Ser Gly Lys Pro Pro Val Ala
                 405                 410                 415    
 Thr Pro Ser Gly Pro His Ser Asn Arg Thr Pro Ser Leu Gln Glu Val
             420                 425                 430        
 Lys Ile Gln Arg Ile Gly Ile Leu Gln Gln Leu Leu Arg Gln Glu Val
         435                 440                 445            
 Glu Gly Leu Val Gly Gly Gln Cys Val Pro Leu Asn Gly Gly Ser Ser
     450                 455                 460                
 Leu Asp Met Val Glu Leu Gln Pro Leu Leu Thr Glu Ile Ser Arg Thr
 465                 470                 475                 480
 Leu Asn Ala Thr Glu His Asn Ser Gly Thr Ser His Leu Pro Gly Leu
                 485                 490                 495    
 Leu Lys His Ser Gly Leu Pro Lys Pro Cys Leu Pro Glu Glu Cys Gly
             500                 505                 510        
 Glu Pro Gln Pro Cys Pro Pro Ala Glu Pro Gly Pro Pro Glu Ala Phe
         515                 520                 525            
 Cys Arg Ser Glu Pro Glu Ile Pro Glu Pro Ser Leu Gln Glu Gln Leu
     530                 535                 540                
 Glu Val Pro Glu Pro Tyr Pro Pro Ala Glu Pro Arg Pro Leu Glu Ser
 545                 550                 555                 560
 Cys Cys Arg Ser Glu Pro Glu Ile Pro Glu Ser Ser Arg Gln Glu Gln
                 565                 570                 575    
 Leu Glu Val Pro Glu Pro Cys Pro Pro Ala Glu Pro Arg Pro Leu Glu
             580                 585                 590        
 Ser Tyr Cys Arg Ile Glu Pro Glu Ile Pro Glu Ser Ser Arg Gln Glu
         595                 600                 605            
 Gln Leu Glu Val Pro Glu Pro Cys Pro Pro Ala Glu Pro Gly Pro Leu
     610                 615                 620                
 Gln Pro Ser Thr Gln Gly Gln Ser Gly Pro Pro Gly Pro Cys Pro Arg
 625                 630                 635                 640
 Val Glu Leu Gly Ala Ser Glu Pro Cys Thr Leu Glu His Arg Ser Leu
                 645                 650                 655    
 Glu Pro Ser Leu Pro Pro Cys Cys Ser Gln Trp Ala Pro Ala Thr Thr
             660                 665                 670        
 Ser Leu Ile Phe Ser Ser Gln His Pro Leu Cys Ala Ser Pro Pro Ile
         675                 680                 685            
 Cys Ser Phe Gln Ser Leu Arg Pro Pro Ala Gly Gln Ala Gly Leu Ser
     690                 695                 700                
 Ala Asn Leu Ala Pro Leu Glu Pro Leu Ala Leu Lys Gly Ala Ala Phe
 705                 710                 715                 720
 Lys Ser Cys Leu Thr Ala Ile His Cys Phe His Glu Ala Ser Ser Trp
                 725                 730                 735    
 Thr Ile Glu Cys Ala Phe Tyr Thr Ser Arg Ala Pro Pro Ser Gly Pro
             740                 745                 750        
 Thr Arg Val Cys Thr Asn Pro Val Ala Thr Leu Leu Glu Trp Gln Asp
         755                 760                 765            
 Ala Leu Cys Phe Ile Pro Val Gly Ser Ala Ala Pro Gln Gly Ser Pro
     770                 775                 780                





      <210> 2551
      <211> 319
      <212> PRT
      <213> Homo sapiens


      <400> 2551
 Asn Cys Asn Leu Ser Val Gly Ser Ser Cys Leu Ser Leu Ala Ser Val
   1               5                  10                  15    
 Trp Leu Ala Arg Arg Met Trp Thr Leu Arg Ser Pro Leu Thr Arg Ser
              20                  25                  30        
 Leu Tyr Val Asn Met Thr Ser Gly Pro Gly Gly Pro Ala Ala Ala Ala
          35                  40                  45            
 Gly Gly Arg Lys Glu Asn His Gln Trp Tyr Val Cys Asn Arg Glu Lys
      50                  55                  60                
 Leu Cys Glu Ser Leu Gln Ala Val Phe Val Gln Ser Tyr Leu Asp Gln
  65                  70                  75                  80
 Gly Thr Gln Ile Phe Leu Asn Asn Ser Ile Glu Lys Ser Gly Trp Leu
                  85                  90                  95    
 Phe Ile Gln Leu Tyr His Ser Phe Val Ser Ser Val Phe Ser Leu Phe
             100                 105                 110        
 Met Ser Arg Thr Ser Ile Asn Gly Leu Leu Gly Arg Gly Ser Met Phe
         115                 120                 125            
 Val Phe Ser Pro Asp Gln Phe Gln Arg Leu Leu Lys Ile Asn Pro Asp
     130                 135                 140                
 Trp Lys Thr His Arg Leu Leu Asp Leu Gly Ala Gly Asp Gly Glu Val
 145                 150                 155                 160
 Thr Lys Ile Met Ser Pro His Phe Glu Glu Ile Tyr Ala Thr Glu Leu
                 165                 170                 175    
 Ser Glu Thr Met Ile Trp Gln Leu Gln Lys Lys Lys Tyr Arg Val Leu
             180                 185                 190        
 Gly Ile Asn Glu Trp Gln Asn Thr Gly Phe Gln Tyr Asp Val Ile Ser
         195                 200                 205            
 Cys Leu Asn Leu Leu Asp Arg Cys Asp Gln Pro Leu Thr Leu Leu Lys
     210                 215                 220                
 Asp Ile Arg Ser Val Leu Glu Pro Thr Arg Gly Arg Val Ile Leu Ala
 225                 230                 235                 240
 Leu Val Leu Pro Phe His Pro Tyr Val Glu Asn Val Gly Gly Lys Trp
                 245                 250                 255    
 Glu Lys Pro Ser Glu Ile Leu Glu Ile Lys Gly Gln Asn Trp Glu Glu
             260                 265                 270        
 Gln Val Asn Ser Leu Pro Glu Val Phe Arg Lys Ala Gly Phe Val Ile
         275                 280                 285            
 Glu Ala Phe Thr Arg Leu Pro Tyr Leu Cys Glu Gly Asp Met Tyr Asn
     290                 295                 300                
 Asp Tyr Tyr Val Leu Asp Asp Ala Val Phe Val Leu Lys Pro Val
 305                 310                 315                



      <210> 2552
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 2552
 Met Gly Ser Ser Val Leu Ser Ile Trp Ile Leu Ser Pro Ser Ile Tyr
   1               5                  10                  15    
 Pro Ile Leu Ser Pro Leu Ala Met Pro Cys Leu Ser Arg Thr Asp Leu
              20                  25                  30        
 Ile Arg Val Arg Arg Ile Gln Gly Ala Trp Pro Ser Glu Gly Thr Ala
          35                  40                  45            
 Ser Ser Ile Arg Gly Trp Val Leu Thr Lys Leu Arg Met Ser Ser Gly
      50                  55                  60                
 Lys Ala Leu Glu Ala Leu Tyr Cys Ile Pro Gly Ala Ala Gln His Pro
  65                  70                  75                  80
 Gly Leu Gly Val Thr Arg Val Trp Ser Gly Arg Thr
                  85                  90        



      <210> 2553
      <211> 102
      <212> PRT
      <213> Homo sapiens


      <400> 2553
 Phe Ala Phe Pro His Tyr Tyr Ile Lys Pro Tyr His Leu Lys Arg Ile
   1               5                  10                  15    
 His Arg Ala Val Leu Arg Gly Asn Leu Glu Lys Leu Lys Tyr Leu Leu
              20                  25                  30        
 Leu Thr Tyr Tyr Asp Ala Asn Lys Arg Asp Arg Lys Glu Arg Thr Ala
          35                  40                  45            
 Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met Val His Leu Leu
      50                  55                  60                
 Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg Glu Asp Arg Thr
  65                  70                  75                  80
 Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala Cys Ala Thr Leu
                  85                  90                  95    
 Leu Leu Gln Asn Gly Ala
             100        



      <210> 2554
      <211> 470
      <212> PRT
      <213> Homo sapiens


      <400> 2554
 Pro Ser Ile Pro Ala Ala Val Pro Gln Ser Ala Pro Pro Glu Pro His
   1               5                  10                  15    
 Arg Glu Glu Thr Val Thr Ala Thr Ala Thr Ser Gln Val Ala Gln Gln
              20                  25                  30        
 Pro Pro Ala Ala Ala Ala Pro Gly Glu Gln Ala Val Ala Gly Pro Ala
          35                  40                  45            
 Pro Ser Thr Val Pro Ser Ser Thr Ser Lys Asp Arg Pro Val Ser Gln
      50                  55                  60                
 Pro Ser Leu Val Gly Ser Lys Glu Glu Pro Pro Pro Ala Arg Ser Gly
  65                  70                  75                  80
 Ser Gly Gly Gly Ser Ala Lys Glu Pro Gln Glu Glu Arg Ser Gln Gln
                  85                  90                  95    
 Gln Asp Asp Ile Glu Glu Leu Glu Thr Lys Ala Val Gly Met Ser Asn
             100                 105                 110        
 Asp Gly Arg Phe Leu Lys Phe Asp Ile Glu Ile Gly Arg Gly Ser Phe
         115                 120                 125            
 Lys Thr Val Tyr Lys Gly Leu Asp Thr Glu Thr Thr Val Glu Val Ala
     130                 135                 140                
 Trp Cys Glu Leu Gln Asp Arg Lys Leu Thr Lys Ser Glu Arg Gln Arg
 145                 150                 155                 160
 Phe Lys Glu Glu Ala Glu Met Leu Lys Gly Leu Gln His Pro Asn Ile
                 165                 170                 175    
 Val Arg Phe Tyr Asp Ser Trp Glu Ser Thr Val Lys Gly Lys Lys Cys
             180                 185                 190        
 Ile Val Leu Val Thr Glu Leu Met Thr Ser Gly Thr Leu Lys Thr Tyr
         195                 200                 205            
 Leu Lys Arg Phe Lys Val Met Lys Ile Lys Val Leu Arg Ser Trp Cys
     210                 215                 220                
 Arg Gln Ile Leu Lys Gly Leu Gln Phe Leu His Thr Arg Thr Pro Pro
 225                 230                 235                 240
 Ile Ile His Arg Asp Leu Lys Cys Asp Asn Ile Phe Ile Thr Gly Pro
                 245                 250                 255    
 Thr Gly Ser Val Lys Ile Gly Asp Leu Gly Leu Ala Thr Leu Lys Arg
             260                 265                 270        
 Ala Ser Phe Ala Lys Ser Val Ile Gly Thr Pro Glu Phe Met Ala Pro
         275                 280                 285            
 Glu Met Tyr Glu Glu Lys Tyr Asp Glu Ser Val Asp Val Tyr Ala Phe
     290                 295                 300                
 Gly Met Cys Met Leu Glu Met Ala Thr Ser Glu Tyr Pro Tyr Ser Glu
 305                 310                 315                 320
 Cys Gln Asn Ala Ala Gln Ile Tyr Arg Arg Val Thr Ser Gly Val Lys
                 325                 330                 335    
 Pro Ala Ser Phe Asp Lys Val Ala Ile Pro Glu Val Lys Glu Ile Ile
             340                 345                 350        
 Glu Gly Cys Ile Arg Gln Asn Lys Asp Glu Arg Tyr Ser Ile Lys Asp
         355                 360                 365            
 Leu Leu Asn His Ala Phe Phe Gln Glu Glu Thr Gly Val Arg Val Glu
     370                 375                 380                
 Leu Ala Glu Glu Asp Asp Gly Glu Lys Ile Ala Ile Lys Leu Trp Leu
 385                 390                 395                 400
 Arg Ile Glu Asp Ile Lys Lys Leu Lys Gly Lys Tyr Lys Asp Asn Glu
                 405                 410                 415    
 Ala Ile Glu Phe Ser Phe Asp Leu Glu Arg Asn Val Pro Glu Asp Val
             420                 425                 430        
 Ala Gln Glu Met Val Glu Ser Gly Tyr Val Cys Glu Gly Asp His Lys
         435                 440                 445            
 Thr Met Ala Lys Ala Ile Lys Asp Arg Val Ser Leu Ile Lys Arg Lys
     450                 455                 460                
 Arg Glu Gln Arg Gln Leu
 465                 470



      <210> 2555
      <211> 470
      <212> PRT
      <213> Homo sapiens


      <400> 2555
 Pro Ser Ile Pro Ala Ala Val Pro Gln Ser Ala Pro Pro Glu Pro His
   1               5                  10                  15    
 Arg Glu Glu Thr Val Thr Ala Thr Ala Thr Ser Gln Val Ala Gln Gln
              20                  25                  30        
 Pro Pro Ala Ala Ala Ala Pro Gly Glu Gln Ala Val Ala Gly Pro Ala
          35                  40                  45            
 Pro Ser Thr Val Pro Ser Ser Thr Ser Lys Asp Arg Pro Val Ser Gln
      50                  55                  60                
 Pro Ser Leu Val Gly Ser Lys Glu Glu Pro Pro Pro Ala Arg Ser Gly
  65                  70                  75                  80
 Ser Gly Gly Gly Ser Ala Lys Glu Pro Gln Glu Glu Arg Ser Gln Gln
                  85                  90                  95    
 Gln Asp Asp Ile Glu Glu Leu Glu Thr Lys Ala Val Gly Met Ser Asn
             100                 105                 110        
 Asp Gly Arg Phe Leu Lys Phe Asp Ile Glu Ile Gly Arg Gly Ser Phe
         115                 120                 125            
 Lys Thr Val Tyr Lys Gly Leu Asp Thr Glu Thr Thr Val Glu Val Ala
     130                 135                 140                
 Trp Cys Glu Leu Gln Asp Arg Lys Leu Thr Lys Ser Glu Arg Gln Arg
 145                 150                 155                 160
 Phe Lys Glu Glu Ala Glu Met Leu Lys Gly Leu Gln His Pro Asn Ile
                 165                 170                 175    
 Val Arg Phe Tyr Asp Ser Trp Glu Ser Thr Val Lys Gly Lys Lys Cys
             180                 185                 190        
 Ile Val Leu Val Thr Glu Leu Met Thr Ser Gly Thr Leu Lys Thr Tyr
         195                 200                 205            
 Leu Lys Arg Phe Lys Val Met Lys Ile Lys Val Leu Arg Ser Trp Cys
     210                 215                 220                
 Arg Gln Ile Leu Lys Gly Leu Gln Phe Leu His Thr Arg Thr Pro Pro
 225                 230                 235                 240
 Ile Ile His Arg Asp Leu Lys Cys Asp Asn Ile Phe Ile Thr Gly Pro
                 245                 250                 255    
 Thr Gly Ser Val Lys Ile Gly Asp Leu Gly Leu Ala Thr Leu Lys Arg
             260                 265                 270        
 Ala Ser Phe Ala Lys Ser Val Ile Gly Thr Pro Glu Phe Met Ala Pro
         275                 280                 285            
 Glu Met Tyr Glu Glu Lys Tyr Asp Glu Ser Val Asp Val Tyr Ala Phe
     290                 295                 300                
 Gly Met Cys Met Leu Glu Met Ala Thr Ser Glu Tyr Pro Tyr Ser Glu
 305                 310                 315                 320
 Cys Gln Asn Ala Ala Gln Ile Tyr Arg Arg Val Thr Ser Gly Val Lys
                 325                 330                 335    
 Pro Ala Ser Phe Asp Lys Val Ala Ile Pro Glu Val Lys Glu Ile Ile
             340                 345                 350        
 Glu Gly Cys Ile Arg Gln Asn Lys Asp Glu Arg Tyr Ser Ile Lys Asp
         355                 360                 365            
 Leu Leu Asn His Ala Phe Phe Gln Glu Glu Thr Gly Val Arg Val Glu
     370                 375                 380                
 Leu Ala Glu Glu Asp Asp Gly Glu Lys Ile Ala Ile Lys Leu Trp Leu
 385                 390                 395                 400
 Arg Ile Glu Asp Ile Lys Lys Leu Lys Gly Lys Tyr Lys Asp Asn Glu
                 405                 410                 415    
 Ala Ile Glu Phe Ser Phe Asp Leu Glu Arg Asn Val Pro Glu Asp Val
             420                 425                 430        
 Ala Gln Glu Met Val Glu Ser Gly Tyr Val Cys Glu Gly Asp His Lys
         435                 440                 445            
 Thr Met Ala Lys Ala Ile Lys Asp Arg Val Ser Leu Ile Lys Arg Lys
     450                 455                 460                
 Arg Glu Gln Arg Gln Leu
 465                 470



      <210> 2556
      <211> 106
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(106)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2556
 Leu Ile Phe Cys Arg Val Phe Glu Tyr Leu His Ser Leu His Leu Pro
   1               5                  10                  15    
 Gln Glu Ile Cys Leu Ser Leu Ala Leu Phe Ser Arg Phe Thr Phe Cys
              20                  25                  30        
 Val Ile Ile Cys Glu Val Asp Val Trp Ser Val Ile Phe Lys Val Pro
          35                  40                  45            
 Phe Cys Ser Lys Arg Asn Lys Val Ala Val His Thr Met Leu Tyr Ile
      50                  55                  60                
 Gln Ile Phe Val Ser Leu Phe Ile Xaa Pro Gln Asn Trp Lys Gln Pro
  65                  70                  75                  80
 Lys Cys Pro Ala Thr Val Glu Arg Ile Asn Lys Met Trp Tyr Ile His
                  85                  90                  95    
 Ile Val Glu Tyr Tyr Ser Ala Asn Lys Arg
             100                 105    



      <210> 2557
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 2557
 Asp Glu Glu Leu Pro Asp Leu Ser Val Ser Arg Arg Ser Ser His Leu
   1               5                  10                  15    
 His Trp Gly Ile Pro Val Pro Gly Tyr Asp Ser Gln Thr Ile Tyr Val
              20                  25                  30        
 Trp Leu Asp Ala Leu Val Asn Tyr Leu Thr Val Ile Gly Tyr Pro Asn
          35                  40                  45            
 Ala Glu Phe Lys Ser Trp Trp Pro Ala Thr Ser His Ile Ile Gly Lys
      50                  55                  60                
 Asp Ile Leu Lys Phe His Ala Ile Tyr Trp Pro Ala Phe Leu Leu Gly
  65                  70                  75                  80
 Ala Gly Met Ser Pro Pro Gln Arg Ile Cys Val His Ser His Trp Thr
                  85                  90                  95    
 Val Cys Gly Gln Lys Met Ser Lys Ser Leu Gly Asn Val Val Asp Pro
             100                 105                 110        
 Arg Thr Cys Leu Asn Arg Tyr Thr Val Asp Gly Phe Arg Tyr Phe Leu
         115                 120                 125            
 Leu Arg Gln Gly Val Pro Asn Trp Asp Cys Asp Tyr Tyr Asp Glu Lys
     130                 135                 140                
 Val Val Lys Leu Leu Asn Ser Glu Leu Ala Asp Ala Leu Gly Gly Leu
 145                 150                 155                 160
 Leu Asn Arg Cys Thr Ala Lys Arg Ile Asn
                 165                 170



      <210> 2558
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 2558
 Met Ile Leu Gln Val Ser Gly Gly Pro Trp Thr Val Ala Leu Thr Ala
   1               5                  10                  15    
 Leu Leu Met Val Leu Leu Ile Ser Val Val Gln Ser Arg Ala Thr Pro
              20                  25                  30        
 Glu Asn Ser Val Tyr Gln Glu Arg Gln Glu Cys Tyr Ala Phe Asn Gly
          35                  40                  45            
 Thr Gln Arg Val Val Asp Gly Leu Ile Tyr Asn Arg Glu Glu Tyr Val
      50                  55                  60                
 His Phe Asp Ser Ala Val Gly Glu Phe Leu Ala Val Met Glu Leu Gly
  65                  70                  75                  80
 Arg Pro Ile Gly Glu Tyr Phe Asn Ser Gln Lys Asp Phe Met Glu Arg
                  85                  90                  95    
 Lys Arg Ala Glu Val Asp Lys Val Cys Arg His Lys Tyr Glu Leu Met
             100                 105                 110        
 Glu Pro Leu Ile Arg Gln Arg Arg Gly Asp Val Thr Ile Thr Ala Val
         115                 120                 125            
 Arg Gly Cys Trp Thr Thr Ile Leu Ser Gly Tyr Phe Leu Leu Lys Arg
     130                 135                 140                
 Gly Val Val Ser Gly Gly Cys Ser Trp Gly Ser Ser
 145                 150                 155    



      <210> 2559
      <211> 257
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(257)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2559
 Ser Thr Gln Arg Gly Gly Ile Lys Gly Val Ala Arg Ala Ala Ser Leu
   1               5                  10                  15    
 Val Gly Arg Arg Arg Ala Gly Thr Gly Met Ala Leu Leu Leu Cys Leu
              20                  25                  30        
 Val Cys Leu Thr Ala Ala Leu Ala His Gly Cys Leu His Cys His Ser
          35                  40                  45            
 Asn Phe Ser Lys Lys Phe Ser Phe Tyr Arg His His Val Asn Phe Lys
      50                  55                  60                
 Ser Trp Trp Val Gly Asp Ile Pro Val Ser Gly Ala Leu Leu Thr Asp
  65                  70                  75                  80
 Trp Ser Asp Asp Thr Met Lys Glu Leu His Leu Ala Ile Pro Ala Lys
                  85                  90                  95    
 Ile Thr Arg Glu Lys Leu Asp Gln Val Ala Thr Ala Val Tyr Gln Met
             100                 105                 110        
 Met Asp Gln Leu Tyr Gln Gly Lys Met Tyr Phe Pro Gly Tyr Phe Pro
         115                 120                 125            
 Asn Glu Leu Arg Asn Ile Phe Arg Glu Gln Val His Leu Ile Gln Asn
     130                 135                 140                
 Ala Ile Ile Glu Ser Arg Ile Asp Cys Gln His Arg Cys Gly Ile Phe
 145                 150                 155                 160
 Gln Tyr Glu Thr Ile Ser Cys Asn Asn Cys Thr Asp Ser His Val Ala
                 165                 170                 175    
 Cys Phe Gly Tyr Asn Cys Glu Ser Ser Ala Gln Trp Lys Ser Ala Val
             180                 185                 190        
 Gln Gly Leu Leu Asn Tyr Ile Asn Asn Trp His Lys Gln Asp Thr Ser
         195                 200                 205            
 Met Arg Pro Arg Ser Ser Ala Phe Ser Trp Pro Gly Thr His Arg Ala
     210                 215                 220                
 Ala Pro Ala Phe Leu Val Leu Pro Ala Leu Arg Cys Leu Glu Pro Pro
 225                 230                 235                 240
 His Leu Ala Asn Leu Ser Leu Glu Asp Ala Ala Xaa Cys Leu Lys Gln
                 245                 250                 255    
 His
    



      <210> 2560
      <211> 257
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(257)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2560
 Ser Thr Gln Arg Gly Gly Ile Lys Gly Val Ala Arg Ala Ala Ser Leu
   1               5                  10                  15    
 Val Gly Arg Arg Arg Ala Gly Thr Gly Met Ala Leu Leu Leu Cys Leu
              20                  25                  30        
 Val Cys Leu Thr Ala Ala Leu Ala His Gly Cys Leu His Cys His Ser
          35                  40                  45            
 Asn Phe Ser Lys Lys Phe Ser Phe Tyr Arg His His Val Asn Phe Lys
      50                  55                  60                
 Ser Trp Trp Val Gly Asp Ile Pro Val Ser Gly Ala Leu Leu Thr Asp
  65                  70                  75                  80
 Trp Ser Asp Asp Thr Met Lys Glu Leu His Leu Ala Ile Pro Ala Lys
                  85                  90                  95    
 Ile Thr Arg Glu Lys Leu Asp Gln Val Ala Thr Ala Val Tyr Gln Met
             100                 105                 110        
 Met Asp Gln Leu Tyr Gln Gly Lys Met Tyr Phe Pro Gly Tyr Phe Pro
         115                 120                 125            
 Asn Glu Leu Arg Asn Ile Phe Arg Glu Gln Val His Leu Ile Gln Asn
     130                 135                 140                
 Ala Ile Ile Glu Ser Arg Ile Asp Cys Gln His Arg Cys Gly Ile Phe
 145                 150                 155                 160
 Gln Tyr Glu Thr Ile Ser Cys Asn Asn Cys Thr Asp Ser His Val Ala
                 165                 170                 175    
 Cys Phe Gly Tyr Asn Cys Glu Ser Ser Ala Gln Trp Lys Ser Ala Val
             180                 185                 190        
 Gln Gly Leu Leu Asn Tyr Ile Asn Asn Trp His Lys Gln Asp Thr Ser
         195                 200                 205            
 Met Arg Pro Arg Ser Ser Ala Phe Ser Trp Pro Gly Thr His Arg Ala
     210                 215                 220                
 Ala Pro Ala Phe Leu Val Leu Pro Ala Leu Arg Cys Leu Glu Pro Pro
 225                 230                 235                 240
 His Leu Ala Asn Leu Ser Leu Glu Asp Ala Ala Xaa Cys Leu Lys Gln
                 245                 250                 255    
 His
    



      <210> 2561
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 2561
 Ala Gly Asp His Val Ser Arg Asn Ile Pro Val Ala Thr Asn Asn Pro
   1               5                  10                  15    
 Val Arg Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly
              20                  25                  30        
 Asp Pro Gln Asn Lys Asp Cys Thr Leu Ser Ile Arg Asp Thr Arg Glu
          35                  40                  45            
 Ser Asp Ala Gly Thr Tyr Val Phe Cys Val Glu Arg Gly Asn Met Lys
      50                  55                  60                
 Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Ser Gln
  65                  70                  75                  80
 Asp Leu Leu Ser Arg Tyr Arg Leu Glu Val Pro Glu Ser Val Thr Val
                  85                  90                  95    
 Gln Glu Gly Leu Cys Val Ser Val Pro Cys Ser Val Leu Tyr Pro His
             100                 105                 110        
 Tyr Asn Trp Thr Ala Ser Ser Pro Val Tyr Gly Ser
         115                 120                



      <210> 2562
      <211> 265
      <212> PRT
      <213> Homo sapiens


      <400> 2562
 Ala His Leu Ser Ala Arg Leu Ser Ala Leu Ile Leu Asp Glu Val Ala
   1               5                  10                  15    
 Ile Leu Pro Ala Pro Gln Asn Leu Ser Val Leu Ser Thr Asn Met Lys
              20                  25                  30        
 His Leu Leu Met Trp Ser Pro Val Ile Ala Pro Gly Glu Thr Val Tyr
          35                  40                  45            
 Tyr Ser Val Glu Tyr Gln Gly Glu Tyr Glu Ser Leu Tyr Thr Ser His
      50                  55                  60                
 Ile Trp Ile Pro Ser Ser Trp Cys Ser Leu Thr Glu Gly Pro Glu Cys
  65                  70                  75                  80
 Asp Val Thr Asp Asp Ile Thr Ala Thr Val Pro Tyr Asn Leu Arg Val
                  85                  90                  95    
 Arg Ala Thr Leu Gly Ser Gln Thr Ser Cys Leu Glu His Pro Val Ser
             100                 105                 110        
 Ile Pro Leu Ile Glu Thr Gln Pro Ser Leu Pro Asp Leu Arg Met Glu
         115                 120                 125            
 Ile Thr Lys Asp Gly Phe His Leu Val Ile Glu Leu Glu Asp Leu Gly
     130                 135                 140                
 Pro Gln Phe Glu Phe Leu Val Ala Tyr Trp Arg Arg Glu Pro Gly Ala
 145                 150                 155                 160
 Glu Glu His Val Lys Met Val Arg Ser Gly Gly Ile Pro Val His Leu
                 165                 170                 175    
 Glu Thr Met Glu Pro Gly Ala Ala Tyr Cys Val Lys Ala Gln Thr Phe
             180                 185                 190        
 Val Lys Ala Ile Gly Arg Tyr Ser Ala Phe Ser Gln Thr Glu Cys Val
         195                 200                 205            
 Glu Val Gln Gly Glu Ala Ile Pro Leu Val Leu Ala Leu Phe Ala Phe
     210                 215                 220                
 Val Gly Phe Met Leu Ile Leu Val Val Val Pro Leu Phe Val Trp Lys
 225                 230                 235                 240
 Met Gly Arg Leu Leu Gln Tyr Leu Leu Leu Pro Arg Gly Gly Ser Ser
                 245                 250                 255    
 Gln Thr Pro Trp Lys Ile Thr Gln Phe
             260                 265



      <210> 2563
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 2563
 Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser Ser
   1               5                  10                  15    
 Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu Leu Thr
              20                  25                  30        
 Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln Lys
          35                  40                  45            
 Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys Gln Arg
      50                  55                  60                
 Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu
  65                  70                  75                  80
 Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Val Pro Ser Glu Glu
                  85                  90                  95    
 Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe Asn
             100                 105                 110        
 Ile Gln Ala Val Asn Arg Met
         115                



      <210> 2564
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 2564
 Met Thr Phe Leu Ile Leu Ser Ile Ala Pro Val Leu Ala Val Thr Gly
   1               5                  10                  15    
 Met Ile Glu Thr Ala Ala Met Thr Gly Phe Ala Asn Lys Asp Lys Gln
              20                  25                  30        
 Glu Leu Lys His Ala Gly Lys Gln Leu Lys Leu Trp Arg Ile Tyr Val
          35                  40                  45            
 Leu
    


